bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Emerging Roles of Extracellular Vesicles in Ovarian Cancer
Authors: Wang Yin-Xue , Wang Yi-Xiang , Li Yi-Ke , Tu Shi-Yan , Wang Yi-Qing 
Published: November 2020

:
Ovarian cancer (OC) is one of the deadliest gynecological malignancy. Epithelial ovarian cancer
(EOC) is its most common form. OC has both, a poor prognosis and a high mortality rate due to the difficulties
of early diagnosis, limitation of current treatment and resistance to chemotherapy. Extracellular vesicles (EVs)
is a heterogeneous group of cell-derived submicron vesicles, which can be detected in body fluids, and it can be
classified into three main types including exosomes, micro-vesicles, and apoptotic bodies.

:
Cancer cells can produce more EVs than healthy cells. Moreover, the contents of these EVs have been found
distinctive from each other. It has been considered that EVs shedding from tumor cells may be implicated in
clinical applications, such as a tool for tumor diagnosis, prognosis and potential treatment of certain cancers.

:
In this review, we provide a brief description of EVs. in diagnosis, prognosis, treatment, and drug-resistantance
of OC. Cancer-related EVs show powerful influences on tumors by various biological mechanisms. However,
the contents mentioned above remain in the laboratory stage and there is a lack of large-scale clinical trials, and
the maturity of the purification and detection methods is a constraint. In addition, amplification of oncogenes
on ecDNA is remarkably prevalent in cancer. It may be possible that ecDNA can be encapsulated in EVs and
thus detected by us. In summary, much more research on EVs needs to be performed to reveal breakthroughs in
OC and to accelerate the process of its application in clinic.
Hepatoprotective and Curative Activities of Daphne Gnidium L. Aqueous Extract Against CCl4-Induced Liver Injury in Rats
Authors: Medila Ifriqya , Toumi Ikram , Adaika Aicha 
Published: November 2020

Background:
The liver is one of the largest organs of the human body and the main site
for intense metabolism and excretion. Liver injury or dysfunction is recognized as a serious worldwide
health problem. Daphne gnidium L., a medicinal plant widely distributed in Algeria and used
by populations in traditional medicine to treat hepatitis and other diseases.

Objective:
Protective and curative effects of aqueous extract of Daphne gnidium L. leaves were investigated
against Carbon Tetrachloride (CCl4) induced hepatic damage in rats (Wistar Albino).

Method:
This study was conducted on 32 Albino rats, which were divided into four groups; the
first served as control. Group II animals were treated intraperitoneally with CCl4solution (3ml/
kg). Group III animals were treated intraperitoneally with CCl4solutions (3ml/kg) on the first
day, and given aqueous Daphne extract orally at a dose level of (300 mg/kg) daily for 7 days (curative
activity test). Animals of group IV were orally administered aqueous Daphne extract at a dose
level of (300 mg/kg) daily, and on the seventh day treated intraperitoneally with CCl4solution (3ml/
kg) 3 hours after the latest extract administration (preventive activity test).

Results:
Our results show that CCl4significantly increases the relative liver weight, serum values
of ALT, AST, ALP, GGT, and Total bilirubin, as well as the hepatic rate of oxidative stress parameters;
MDA and CAT activities, and significantly decreases hepatic GSH levels compared to the control
group. These results were confirmed by liver lesions observed in histological analyses. Pretreatment
and curative treatment of dose 300 mg/kg of aqueous Daphne gnidium L. extract significantly
reduced relative weight, serum levels of ALT, AST, ALP, GGT and Total bilirubin liver
rate, CAT activity, and increases GSH level. In addition, normal liver architecture has been restored.

Conclusion:
The present study demonstrates the hepatoprotective and curative effects of aqueous
extract Daphne gnidium leaves against CCl4-induced liver injury in rats by improving the antioxidant
status in tissues (liver) and ameliorating the harmful effects induced by CCl4
Alcohol Determination by HPLC with Postcolumn Derivatization Based on the Thiosulfate-catalyzed Reaction of Alcohols and Cerium(IV) and Fluorescence Detection of Cerium(III)
Authors: Mikami Ikko , Shibayama Eri , Takagi Kengo 
Published: November 2020

Background:
Determination of a reducing substance based on the reaction between
Ce(IV) and a reducing substance and fluorescence detection of Ce(III) generated has been reported
as a selective and sensitive method. However, this method could not be applied to the determination
of alcohol due to the low reaction rate of alcohol and Ce(IV).

Objective:
We found that thiosulfate catalytically enhanced the reaction of alcohols (such as, methanol,
ethanol, and propanol) and Ce(IV). Utilizing this effect, we developed a new method for the
determination of alcohols.

Methods:
Alcohols were detected using the reaction of Ce(IV) with alcohols in the presence of
thiosulfate and fluorescence detection of the Ce(III) generated by the reaction.

Results:
In the presence of thiosulfate, an increase in fluorescence intensity was detected by injecting
alcohol at concentrations of several millimolar, whereas it was not observed even at the concentration
of 10% v/v (2 M for ethanol) in the absence of thiosulfate. The optimum detection conditions
were determined to be 4.0 mM Ce(IV) sulfate and 0.50 mM thiosulfate, and the detection
limit (S/N = 3) of ethanol under these conditions was 1 mM. In the calibration curves, changes in
the slope were observed when the alcohol concentrations were approximately 10–25 mM. Using a
thiosulfate solution containing ethanol as the reaction solution, a calibration curve without any
change in slope was obtained, although the concentration of ethanol at the detection limit increased.
The alcohols in the liquor and fuel were successfully analyzed using the proposed detection method
as a postcolumn reaction.

Conclusion:
This new alcohol detection method using a versatile fluorescence detector can be applied
to the postcolumn reaction of HPLC omitting need of time-consuming pretreatment processes.
Correlations and Hierarchical Clustering Investigation Between Weather
and SARS-CoV-2
Authors: El Handri Kaoutar , Idrissi Abdellah 
Published: November 2020

Background::
Humanity today faces a global emergency. It is conceivably the greatest crisis of our generation. The coronavirus pandemic, which has many global implications, has led researchers worldwide to seek solutions to this crisis, including the search for effective treatment in the first place.

Objective::
This study aims to identify the factors that can have an essential effect on COVID-19 comportment. Having proper management and control of imports of COVID-19 depends on many factors that are highly dependent on a country's sanitary capacity and infrastructure technology. Nevertheless, meteorological parameters can also be a connecting factor to this disease; seines temperature and humidity are compatible with the behavior of a seasonal respiratory virus.

Methods::
In this work, we analyze the correlation between weather and the COVID-19 epidemic in Casablanca, the economic capital of Morocco. It is based on the primary analysis of COVID-19 surveillance data from the Ministry of Health of the Kingdom of Morocco and weather data from the meteorological data. Weather factors include minimum temperature (°C), maximum temperature (°C), mean temperature (°C), maximum wind speed (Km/h), humidity (%), and rainfall (mm). The Spearman and Kendall rank correlation test is used for data analysis. Between the weather components.

Results::
The mean temperature, maximum temperature (°C) and Humidity were significantly correlated with the COVID-19 pandemic with respectively (r= -0.432, r = -0.480; r=0.402, and p=- 0.212, p= -0.160, and p= &-0.240).

Conclusion::
This discovery helps reduce the incidence rate of COVID-19 in Morocco, considering the significant correlation between weather and COVID-19, of about more than 40%.
The Roles of Need for Achievement and Family Environment in Stimulating Entrepreneurial Interest through Self-Efficacy
Authors: Utari Fiarika Dwi , Sukidjo Sukidjo 
Published: November 2020

Abstract: This study was designed to reveal the extent to which the need for achievement and family environment affected entrepreneurial interest through self-efficacy, either directly or indirectly. It used causal associative research with a quantitative approach and drew on information collected from 322 samples selected using the proportional random sampling from a study population of 4.570 students of Yogyakarta State University. The research data were collected using a questionnaire that had been tested for validity and reliability and then analyzed using the path analysis. The results showed that the need for achievement and family environment, directly and indirectly, increased entrepreneurial interest through self-efficacy.Keywords: entrepreneurial interest, family environment, need for achievement, self-efficacy Peran Kebutuhan akan Prestasi dan Lingkungan Keluarga terhadap Minat Berwirausaha melalui Efikasi DiriAbstrak: Penelitian ini bertujuan untuk mengetahui peran kebutuhan akan prestasi dan lingkungan keluarga terhadap minat berwirausaha melalui efikasi diri baik secara langsung maupun tidak langsung. Penelitian ini termasuk penelitian asosiatif kausal dengan pendekatan kuantitatif. Populasi penelitian terdiri dari 4.570 mahasiswa Universitas Negeri Yogyakarta. Adapun jumlah sampel terdiri dari 322 mahasiswa yang ditentukan dengan teknik proportional random sampling. Metode pengumpulan data menggunakan angket yang telah diuji validitas dan reliabilitasnya. Teknik analisis data yang digunakan adalah analisis jalur. Hasil penelitian menunjukkan bahwa kebutuhan akan prestasi dan lingkungan keluarga meningkatkan minat berwirausaha baik secara langsung maupun tidak langsung melalui efikasi diri.Kata Kunci: efikasi diri, kebutuhan akan prestasi, lingkungan keluarga, minat berwirausaha
Financial Performance Analysis on Micro, Small, and Medium Enterprises of Cassava Product in Cibadak, Lebak Regency,
Authors: Mukarromah Denis , Jubaedah Jubaedah , Astuti Miguna 
Published: November 2020

Abstract: There are indications of difficult capital access for MSMEs in Lebak. It is shown by Statistic Bureau (BPS) data in Banten Province that only 7.44% of micro and small businesses in Banten obtain or apply for credit, or only 0.95% of Lebak micro and small businesses that can obtain or apply for credit. This research aims to determine the effect of (1) financial literacy on financial performance and (2) financial management on financial performance. This research is quantitative descriptive. The subjects were MSMEs of cassava processed products in Cibadak, Lebak Regency by distributing questionnaire to 86 samples. The data analysis technique used was descriptive analysis and inferential analysis with Partial Least Square (PLS). The results of this research show that (1) financial literacy has a positive effect on financial performance, and (2) financial management has a positive effect on financial performance.Keywords: financial literacy, financial management, financial performance Analisis Kinerja Keuangan pada Pelaku UMKM Produk Olahan Singkong di Cibadak Kabupaten Lebak, BantenAbstrak: Terdapat indikasi sulitnya akses permodalan pada UMKM di Lebak, Banten. Ditunjukan oleh data BPS Provinsi Banten bahwa hanya 7,44% usaha mikro dan kecil di Banten yang memperoleh ataupun mengajukan kredit atau hanya 0,95% dari usaha mikro dan kecil Lebak yang dapat memperoleh atau mengajukan kredit. Penelitian ini bertujuan untuk mengetahui pengaruh (1) literasi keuangan terhadap kinerja keuangan, (2) pengelolaan keuangan terhadap kinerja keuangan. Bentuk penelitian ini adalah deskriptif kuantitatif. Subjek dalam penelitian ini adalah pelaku UMKM produk olahan Singkong di Cibadak, Kabupaten Lebak dengan penyebaran kuisioner pada 86 sampel. Teknik analisis data yang digunakan adalah analisis deskriptif dan analisis inferensial dengan Partial Least Square (PLS). Hasil penelitian ini menunjukan (1) literasi keuangan berpengaruh positif terhadap kinerja keuangan, dan (2) pengelolaan keuangan berpengaruh positif terhadap kinerja keuangan.Kata kunci: literasi keuangan, pengelolaan keuangan, kinerja keuangan
Maturidade da gestão do conhecimento na Comissão de Implantação do Sistema de Controle do Espaço Aéreo Brasileiro (CISCEA)
Authors: Teixeira Wallace Gonçalves , Frogeri Rodrigo Franklin , Piurcosky Fabrício Pelloso 
Published: November 2020

A Comissão de Implantação do Sistema do Controle do Espaço Aéreo (Ciscea) tem como missão principal a modernização dos ativos dedicados ao controle do espaço aéreo sob a jurisdição do Brasil. Mais do que softwares, aplicativos e equipamentos, o principal ativo do complexo sistema da Ciscea é o seu capital intelectual, que deriva da soma do conhecimento de militares especializados, cuja formação e treinamento são atividades ininterruptas na carreira. Destarte, o objetivo do estudo foi mensurar o grau de maturidade da Gestão do Conhecimento na Ciscea sob a ótica do seu efetivo de militares, como forma de obter um diagnóstico para subsidiar futuras ações estratégicas. Este intento foi conseguido a partir de um estudo de caso com abordagem quantitativa aplicado a 25 militares da Ciscea. Os dados foram analisados por meio de técnicas de estatística descritiva e correlação. Os resultados evidenciaram um nível intermediário de maturidade nas práticas de gestão do conhecimento na Ciscea e revelou que o investimento em recursos humanos pode proporcionar melhores resultados na implementação de um plano de gestão do conhecimento na organização.
An Artificial Intelligence–Based, Personalized Smartphone App to Improve Childhood Immunization Coverage and Timelines Among Children in Pakistan: Protocol for a Randomized Controlled Trial
Authors: Kazi Abdul Momin , Qazi Saad Ahmed , Khawaja Sadori , Ahsan Nazia , Ahmed Rao Moueed , Sameen Fareeha , Khan Mughal Muhammad Ayub , Saqib Muhammad , Ali Sikander , Kaleemuddin Hussain , Rauf Yasir , Raza Mehreen , Jamal Saima , Abbasi Munir , Stergioulas Lampros K 
Published: November 2020

Background
The immunization uptake rates in Pakistan are much lower than desired. Major reasons include lack of awareness, parental forgetfulness regarding schedules, and misinformation regarding vaccines. In light of the COVID-19 pandemic and distancing measures, routine childhood immunization (RCI) coverage has been adversely affected, as caregivers avoid tertiary care hospitals or primary health centers. Innovative and cost-effective measures must be taken to understand and deal with the issue of low immunization rates. However, only a few smartphone-based interventions have been carried out in low- and middle-income countries (LMICs) to improve RCI.

Objective
The primary objectives of this study are to evaluate whether a personalized mobile app can improve children’s on-time visits at 10 and 14 weeks of age for RCI as compared with standard care and to determine whether an artificial intelligence model can be incorporated into the app. Secondary objectives are to determine the perceptions and attitudes of caregivers regarding childhood vaccinations and to understand the factors that might influence the effect of a mobile phone–based app on vaccination improvement.

Methods
A mixed methods randomized controlled trial was designed with intervention and control arms. The study will be conducted at the Aga Khan University Hospital vaccination center. Caregivers of newborns or infants visiting the center for their children’s 6-week vaccination will be recruited. The intervention arm will have access to a smartphone app with text, voice, video, and pictorial messages regarding RCI. This app will be developed based on the findings of the pretrial qualitative component of the study, in addition to no-show study findings, which will explore caregivers’ perceptions about RCI and a mobile phone–based app in improving RCI coverage.

Results
Pretrial qualitative in-depth interviews were conducted in February 2020. Enrollment of study participants for the randomized controlled trial is in process. Study exit interviews will be conducted at the 14-week immunization visits, provided the caregivers visit the immunization facility at that time, or over the phone when the children are 18 weeks of age.

Conclusions
This study will generate useful insights into the feasibility, acceptability, and usability of an Android-based smartphone app for improving RCI in Pakistan and in LMICs.

Trial Registration
ClinicalTrials.gov NCT04449107; https://clinicaltrials.gov/ct2/show/NCT04449107

International Registered Report Identifier (IRRID)
DERR1-10.2196/22996
A Text Messaging Intervention for Coping With Social Distancing During COVID-19 (StayWell at Home): Protocol for a Randomized Controlled Trial
Authors: Figueroa Caroline Astrid , Hernandez-Ramos Rosa , Boone Claire Elizabeth , Gómez-Pathak Laura , Yip Vivian , Luo Tiffany , Sierra Valentín , Xu Jing , Chakraborty Bibhas , Darrow Sabrina , Aguilera Adrian 
Published: November 2020

Background
Social distancing is a crucial intervention to slow down person-to-person transmission of COVID-19. However, social distancing has negative consequences, including increases in depression and anxiety. Digital interventions, such as text messaging, can provide accessible support on a population-wide scale. We developed text messages in English and Spanish to help individuals manage their depressive mood and anxiety during the COVID-19 pandemic.

Objective
In a two-arm randomized controlled trial, we aim to examine the effect of our 60-day text messaging intervention. Additionally, we aim to assess whether the use of machine learning to adapt the messaging frequency and content improves the effectiveness of the intervention. Finally, we will examine the differences in daily mood ratings between the message categories and time windows.

Methods
The messages were designed within two different categories: behavioral activation and coping skills. Participants will be randomized into (1) a random messaging arm, where message category and timing will be chosen with equal probabilities, and (2) a reinforcement learning arm, with a learned decision mechanism for choosing the messages. Participants in both arms will receive one message per day within three different time windows and will be asked to provide their mood rating 3 hours later. We will compare self-reported daily mood ratings; self-reported depression, using the 8-item Patient Health Questionnaire; and self-reported anxiety, using the 7-item Generalized Anxiety Disorder scale at baseline and at intervention completion.

Results
The Committee for the Protection of Human Subjects at the University of California Berkeley approved this study in April 2020 (No. 2020-04-13162). Data collection began in April 2020 and will run to April 2021. As of August 24, 2020, we have enrolled 229 participants. We plan to submit manuscripts describing the main results of the trial and results from the microrandomized trial for publication in peer-reviewed journals and for presentations at national and international scientific meetings.

Conclusions
Results will contribute to our knowledge of effective psychological tools to alleviate the negative effects of social distancing and the benefit of using machine learning to personalize digital mental health interventions.

Trial Registration
ClinicalTrials.gov NCT04473599; https://clinicaltrials.gov/ct2/show/NCT04473599

International Registered Report Identifier (IRRID)
DERR1-10.2196/23592
William Ritter et Józef Mehoffer : échange épistolaire autour de l’art slave
Authors: Carraux Noémie 
Published: November 2020

William Ritter et Józef Mehoffer ont entretenu une correspondance pendant soixante ans. Celle-ci débute en 1898, lorsque l’artiste remporte le concours pour la réalisation des vitraux de la cathédrale de Fribourg. Si leurs premiers échanges sont très formels, les deux hommes vont rapidement se lier d’amitié. L’étude de cette correspondance nous révèle l’importance du rôle qu’a joué William Ritter comme transmetteur du monde artistique slave à l’Europe occidentale entre la fin du XIXe siècle et le début du XXe siècle.
Keywords: William Ritter, Józef Mehoffer, art slave, Sztuka
Un certain M. Piekielny dans "L’Art de perdre" : la liste Goncourt 2017 passée au crible
Authors: Dongmo Rodrigue Marcel Ateufack 
Published: November 2020

Quoique très prestigieux, le Goncourt ne manque pas de charrier de vives criques dont l’une des plus virulentes assimile son jury à « une maison de retraite » (Renard). Cette étude interroge les répercussions du non-rajeunissement de son jury dans le choix des lauréats de la liste Goncourt 2017 et analyse les dessous des invariants thématique et poétique de cette liste. Elle questionne les enjeux qui ont notamment présidé au choix de L’Ordre du jour d’Éric Vuillard par le Goncourt et à celui de L’Art de perdre d’Alice Zeniter par la plupart des Goncourt jeunes. S’il est vrai que la consécration de ces deux romans par deux jurys que plusieurs décennies séparent traduit un conflit de génération, il y a surtout lieu d’y voir une différence de perspectives, le choix de l’un comme de l’autre étant surtout dicté par la résurgence du nationalisme en Europe.
Keywords: Prix Goncourt, nazisme, immigration, nationalisme, exofiction, sociétés de marché
William Ritter et le wagnérisme : "Ægyptiacque", une « paraphrase wagnérienne » ?
Authors: Vogel Laura 
Published: November 2020

Cet article se propose d’étudier les formes et les limites du wagnérisme dans Ægyptiacque, le premier roman publié par William Ritter, en se concentrant sur les deux personnages principaux. Si les références aux drames wagnériens sont essentielles, elles se doublent de renvois à des figures mythologiques diverses. Ritter reformule aussi la conception wagnérienne de l’amour pour qu’elle corresponde à ses convictions personnelles. Nous commencerons par définir brièvement l’esthétique wagnérienne, avant de présenter le wagnérisme littéraire en France, et de préciser la posture de Ritter dans ce contexte. Enfin, nous examinerons les personnages du roman et terminerons en analysant la manière dont Ritter condamne la vision wagnérienne de l’amour pour proposer, à sa place, un autre idéal amoureux.
Keywords: Ritter, Wagner, wagnérisme, figures mythologiques, reconfiguration
William Ritter photograph(i)e
Authors: Binggeli Thomas 
Published: November 2020

William Ritter multiplie les domaines d’activité et laisse derrière lui des archives dont il est difficile de faire façon. C’est notamment le cas pour la partie photographique de sa production : près de quatre mille clichés qu’il n’a jamais classés et qui reposent en vrac à La Chaux-de-Fonds, à Neuchâtel, et à Berne. Bien que méconnus, ces documents en disent beaucoup sur le monde dans lequel a évolué Ritter, et s’il ne prétend pas être un artiste photographe, il s’inscrit tout à fait bien dans un courant amateur très en vogue dès la fin du xixe siècle. Il documente ainsi son quotidien au gré de ses pérégrinations – en Suisse ou plus largement en Europe centrale – et laisse derrière des photographies dont les sujets sont variés, touchants, parfois très intimes et subversifs. Alors, comment les aborder, et quelle place leur accorder au sein de l’univers Ritter ?
Keywords: William Ritter, photographie amateur, archives