bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cellular basis of loss of smell in 2019-nCoV-infected individuals
Authors: Gupta Krishan , Mohanty Sanjay Kumar , Mittal Aayushi , Kalra Siddhant , Kumar Suvendu , Mishra Tripti , Ahuja Jatin , Sengupta Debarka , Ahuja Gaurav 
Published: July 2020

AbstractA prominent clinical symptom of 2019-novel coronavirus (nCoV) infection is hyposmia/anosmia (decrease or loss of sense of smell), along with general symptoms such as fatigue, shortness of breath, fever and cough. The identity of the cell lineages that underpin the infection-associated loss of olfaction could be critical for the clinical management of 2019-nCoV-infected individuals. Recent research has confirmed the role of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) as key host-specific cellular moieties responsible for the cellular entry of the virus. Accordingly, the ongoing medical examinations and the autopsy reports of the deceased individuals indicate that organs/tissues with high expression levels of ACE2, TMPRSS2 and other putative viral entry-associated genes are most vulnerable to the infection. We studied if anosmia in 2019-nCoV-infected individuals can be explained by the expression patterns associated with these host-specific moieties across the known olfactory epithelial cell types, identified from a recently published single-cell expression study. Our findings underscore selective expression of these viral entry-associated genes in a subset of sustentacular cells (SUSs), Bowman’s gland cells (BGCs) and stem cells of the olfactory epithelium. Co-expression analysis of ACE2 and TMPRSS2 and protein–protein interaction among the host and viral proteins elected regulatory cytoskeleton protein-enriched SUSs as the most vulnerable cell type of the olfactory epithelium. Furthermore, expression, structural and docking analyses of ACE2 revealed the potential risk of olfactory dysfunction in four additional mammalian species, revealing an evolutionarily conserved infection susceptibility. In summary, our findings provide a plausible cellular basis for the loss of smell in 2019-nCoV-infected patients.
Proteomic and metabolomic analyses uncover sex-specific regulatory pathways in mouse fetal germline differentiation†
Authors: Hayashi Yohei , Mori Masaru , Igarashi Kaori , Tanaka Keiko , Takehara Asuka , Ito-Matsuoka Yumi , Kanai Akio , Yaegashi Nobuo , Soga Tomoyoshi , Matsui Yasuhisa 
Published: July 2020

AbstractRegulatory mechanisms of germline differentiation have generally been explained via the function of signaling pathways, transcription factors, and epigenetic regulation; however, little is known regarding proteomic and metabolomic regulation and their contribution to germ cell development. Here, we conducted integrated proteomic and metabolomic analyses of fetal germ cells in mice on embryonic day (E)13.5 and E18.5 and demonstrate sex- and developmental stage-dependent changes in these processes. In male germ cells, RNA processing, translation, oxidative phosphorylation, and nucleotide synthesis are dominant in E13.5 and then decline until E18.5, which corresponds to the prolonged cell division and more enhanced hyper-transcription/translation in male primordial germ cells and their subsequent repression. Tricarboxylic acid cycle and one-carbon pathway are consistently upregulated in fetal male germ cells, suggesting their involvement in epigenetic changes preceding in males. Increased protein stability and oxidative phosphorylation during female germ cell differentiation suggests an upregulation of aerobic energy metabolism, which likely contributes to the proteostasis required for oocyte maturation in subsequent stages. The features elucidated in this study shed light on the unrevealed mechanisms of germ cell development.
Polysaccharide-Based Chiral Stationary Phases on Gold Nanoparticles Modified Silica Beads for Liquid-Phase Separation of Enantiomers
Authors: Li Yuanyuan , Gao Zhuxian , Chen Tong , Wei Manman , Ma Yulong , Ma Xiaoxia , Xu Hong 
Published: July 2020

Abstract
Au nanoparticles (AuNPs) (10−15 nm in size) were prepared and deposited on the surfaces of silica particles functionalized using 3-aminopropyltriethoxysilane as the seeds under mild conditions. Then, Au seeds grew further and formed nanosheets by the method of gold chloride hydrate reduction. 3, 5-dimethylphenyl isocyanate derivative of cellulose as chiral selector was coated on the surfaces of SiO2/Au. The obtained spheres possessed a sandwich structure in which silica bead, the packed Au NPs monolayer and cellulose derivative were the core, the interlayer and the shell, respectively. The resultant packing material was evaluated by high-performance liquid chromatography (HPLC) as chiral stationary phase (CSP). The separations of nine pairs of enantiomers were achieved in the normal-phase liquid chromatography mode. The results showed that the new CSP has sufficient interaction with the analytes due to the existence of AuNPs on silica surfaces compared with coated cellulose-silica column.
A Cotton Disease Diagnosis Method Using a Combined Algorithm of Case-Based Reasoning and Fuzzy Logic
Authors: Dong Yuhong , Fu Zetian , Stankovski Stevan , Peng Yaoqi , Li Xinxing 
Published: July 2020

Abstract
In this study, a cotton disease diagnosis method that uses a combined algorithm of case-based reasoning (CBR) and fuzzy logic was designed and implemented. It focuses on the prevention, diagnosis and control of diseases affecting cotton production in China. Conventional methods of disease diagnosis are primarily based on CBR with reference to user-provided symptoms; however, in most cases, user-provided symptoms do not fully meet the requirements of CBR. To address this problem, fuzzy logic is incorporated into CBR to allow for more flexible and accurate models. With the help of CBR and fuzzy reasoning, three diagnostic results can be obtained by the cotton disease diagnosis system (CDDS) constructed in this study: success, success but not exact and failure. To verify the reliability of the CDDS and its ability to diagnose cotton diseases, its diagnostic accuracy and stability were analyzed and compared with the results obtained by the traditional expert scoring method. The analysis results reveal that the CDDS can achieve a high diagnostic success rate (above 90%) and better diagnostic stability than the traditional expert scoring method when at least four disease symptoms are input. The CDDS provides an independent and objective source of information to assist farmers in the diagnosis and prevention of cotton diseases.
Vaccination Rates and Family Barriers Among Children with Inflammatory Bowel Disease
Authors: Holland Kathleen J , Wilkinson Tracey A , Phipps Erin , Slaven James E , Bennett William E 
Published: July 2020

AbstractBackgroundMany children with inflammatory bowel disease (IBD) are taking immunosuppressant medications that place them at risk for vaccine preventable diseases. Despite national guidelines, children with IBD have low vaccination rates. Adult data suggest that there is concern about the safety of vaccines. There are no current studies addressing perceived safety about vaccinations among families of children with IBD.MethodsA total of 108 caregivers of children (ages 10–25 years) were surveyed during their outpatient visit, with approximately half having a diagnosis of IBD. The survey consisted of validated questions regarding vaccine safety and opinions. After enrollment, state-wide vaccine registry data was collected. Demographics between the 2 groups were compared using chi-square and the Wilcoxon rank-sum tests to analyze Likert-scale questions.ResultsThe majority of children followed for IBD were Caucasian males, had Crohn disease (68%), and were immunosuppressed. Results from the survey revealed a concern about vaccine safety (40% vs 16%, P = 0.03) and overall effectiveness (34% vs 12%, P &lt; 0.01) in the IBD group compared with the non-IBD. Furthermore, more IBD families were worried that vaccines would worsen their child’s symptoms (36% vs 10%, P ≤ 0.01). The majority of children were missing the flu and/or human papilloma virus vaccine. Finally, 96% of the children on a biologic for their IBD were missing the PPSV23 booster.ConclusionsCaregivers of children with IBD are more concerned about vaccine safety and effectiveness than those with non-IBD diagnosis. Despite being on immunosuppressant medications, many patients were missing recommended vaccines.
Successful removal of a circular mapping catheter which perforated the pulmonary vein during cryoballoon ablation by lateral thoracotomy: a case report
Authors: Yoshizawa Reisuke , Owada Shingen , Sawa Yohei , Deguchi Hiroyuki 
Published: July 2020

AbstractBackgroundSerious complications may occur during cryoballoon ablation (CBA). However, pulmonary vein (PV) perforation by a circular mapping catheter and the strategy for removing the catheter remain poorly understood.Case summaryA 40-year-old male presented with palpitations 2 years ago and was diagnosed with paroxysmal atrial fibrillation 5 months ago. He underwent CBA for paroxysmal atrial fibrillation. After isolation of the left PV, a circular mapping catheter was advanced in the right inferior pulmonary vein (RIPV), and single freeze was performed. After isolation of the PV, the catheter tip was immobile and could not be withdrawn with significant resistance. Computed tomography showed that the catheter tip perforated the posterior basal vein (V10) of the RIPV and remained in the right lower lobe, along with intrapulmonary haemorrhage. The patient underwent surgery via right lateral thoracotomy to remove the catheter. The RIPV was peeled to the periphery to expose the V10. The catheter perforated the vessel wall in the middle of the V10 and entered the pulmonary parenchyma. A microincision on the lung parenchyma covering the surface of the catheter tip was performed, and the circular distal portion of the catheter was cut. The entire catheter (i.e. shaft and proximal portion) was successfully removed from the transseptal catheter.DiscussionSurgical approach was performed for the management of PV perforation caused by a circular mapping catheter. This case may assist in troubleshooting and problem-solving in case such an event occurs again during procedures in the future.
A case report of absolute thrombocytopenia with ticagrelor
Authors: Khan Mahin R , Adhikari Govinda , Khan Hafiz , Changezi Hameem U 
Published: July 2020

Abstract

Background
We report a rare case of absolute thrombocytopenia with ticagrelor after 6 h of single loading dose of ticagrelor.

Case summary
A 68-year-old male with ischaemic cardiomyopathy, hypertension, and dyslipidaemia presented with chest pain. He was found to be in new-onset atrial flutter and ruled in for a non-ST-segment elevation myocardial infarction. An echocardiogram showed decreased left ventricular ejection fraction, estimated at 15–20% and serum troponin peaked at 0.2 ng/dL, baseline platelet count was 203 × 103/µL. He underwent a drug-eluting stent placement to the right coronary artery with excellent angiographic results. He received 3000 units of unfractionated heparin and 180 mg of ticagrelor during the procedure. About 6 h after the procedure, he had coffee ground emesis. A complete blood count revealed a platelet count of 2 × 103 and 0 × 103/µL on repeat testing. Peripheral smear did not show any evidence of platelet clumping and schistocytes, serum haptoglobin and lactate dehydrogenase were normal. Ticagrelor and heparin were discontinued, while the aspirin was continued. Five units of platelet were transfused. The platelet count improved to 200 × 103/µL. Since his CHADS2VASC score was 3, he was discharged on apixaban and clopidogrel in addition to other medication. No thrombocytopenia was seen on outpatient follow-up.

Discussion
The common side effects of ticagrelor include bleeding, dyspnoea, gynaecomastia, and rarely thrombotic thrombocytopenic purpura. Although extremely rare, absolute or profound thrombocytopenia can occur with ticagrelor, hours after administration and should be considered when other potential causes of thrombocytopenia have been ruled out.
‘Mobile’izing Agricultural Advice Technology Adoption Diffusion and Sustainability
Authors: Cole Shawn A , Fernando A Nilesh 
Published: July 2020

AbstractMobile phones promise to bring the ICT revolution to previously unconnected populations. A two-year study evaluates an innovative voice-based ICT advisory service for smallholder cotton farmers in India, demonstrating significant demand for, and trust in, new information. Farmers substantially alter their sources of information and consistently adopt inputs for cotton farming recommended by the service. Willingness to pay is, on average, less than the per-farmer cost of operating the service for our study, but likely exceeds the cost at scale. We do not find systematic evidence of gains in yields or profitability, suggesting the need for further research.
Contributions of cis- and trans-Regulatory Evolution to Transcriptomic Divergence across Populations in the Drosophila mojavensis Larval Brain
Authors: Benowitz Kyle M , Coleman Joshua M , Allan Carson W , Matzkin Luciano M 
Published: July 2020

AbstractNatural selection on gene expression was originally predicted to result primarily in cis- rather than trans-regulatory evolution, due to the expectation of reduced pleiotropy. Despite this, numerous studies have ascribed recent evolutionary divergence in gene expression predominantly to trans-regulation. Performing RNA-seq on single isofemale lines from genetically distinct populations of the cactophilic fly Drosophila mojavensis and their F1 hybrids, we recapitulated this pattern in both larval brains and whole bodies. However, we demonstrate that improving the measurement of brain expression divergence between populations by using seven additional genotypes considerably reduces the estimate of trans-regulatory contributions to expression evolution. We argue that the finding of trans-regulatory predominance can result from biases due to environmental variation in expression or other sources of noise, and that cis-regulation is likely a greater contributor to transcriptional evolution across D. mojavensis populations. Lastly, we merge these lines of data to identify several previously hypothesized and intriguing novel candidate genes, and suggest that the integration of regulatory and population-level transcriptomic data can provide useful filters for the identification of potentially adaptive genes.
Post-critical SsPmp and its applications to virtual deep seismic sounding (VDSS)—3: back-projection imaging of the crust–mantle boundary in a heterogeneous lithosphere, theory and application
Authors: Liu Tianze , Klemperer Simon L , Yu Chunquan , Ning Jieyuan 
Published: July 2020

SUMMARYVirtual deep seismic sounding (VDSS) uses the arrival time of post-critical SsPmp relative to the direct S wave to infer Moho depth at the Pmp reflection point. Due to the large offset between the virtual source and the receiver, SsPmp is more sensitive to lateral variations of structures than near-vertical phases such as Ps, which is used to construct conventional P receiver functions. However, the way post-critical SsPmp is affected by lateral variations in lithospheric structure is not well understood, and previous studies largely assumed a 1-D structure when analysing SsPmp waveforms. Here we present synthetic tests with various 2-D models to show that lateral variations in lithospheric structures, from the lithosphere–asthenosphere boundary (LAB) to sedimentary basins, profoundly affect traveltime, phase and amplitude of post-critical SsPmp, and that a 1-D approximation is usually inappropriate when analysing 2-D data. Despite these strong effects we show, with synthetic examples and the ChinArray data from the Ordos Block in northern China, that a simple ray-theory-based back-projection method can retrieve the geometry of the crust–mantle boundary (CMB) given array observations in cases with moderate lateral variations in the CMB and/or the LAB. The success of our back-projection method indicates that ray-theory approximations are sufficient in modelling SsPmp traveltimes in the presence of moderate lateral heterogeneity. In contrast, we show that the ray theory is generally insufficient in modelling SsPmp phase shifts in a strongly heterogeneous lithosphere due to non-planar downgoing P waves incident at the CMB. Nonetheless, our results demonstrate the feasibility of direct imaging of the CMB with post-critical SsPmp even in the presence of 2-D variations of lithospheric structure.
The power of rumour(s) in international interventions: MINUSMA's management of Mali's rumour mill
Authors: Sandor Adam 
Published: July 2020

Abstract
The work of international interventions, whether grandiose or commonplace in scale, requires credible, verified information. Nevertheless, in settings of armed conflict that interventions aim to transform, information is more often than not improvised, unofficial, fragmented and based on multiple competing imaginaries. Interventions, therefore, are significantly influenced by rumours: the circulation of information and stories based on uncertain accounts of questionable provenance. Research on international intervention has neglected the place and power of rumour. To address this lacuna, this article examines the impact of rumour on the intervention logics and practices of the United Nations Multilateral Stabilization Mission in Mali (MINUSMA). It argues that rumours evince an epistemological force that generates constitutive effects among different sets of conflict actors in Mali. To address the impacts of rumours, different divisions within the intervention pursue practices of investigation, correction and officialization. Nevertheless, by enacting these practices, political tensions emerge that reveal contradictory intervention logics within MINUSMA, and foster conflictual relations between the intervention and different conflict actors in the country, thereby decreasing how Malians perceive MINUSMA's legitimacy.
Disentangling the security traffic jam in the Sahel: constitutive effects of contemporary interventionism
Authors: Cold-Ravnkilde Signe Marie , Jacobsen Katja Lindskov 
Published: July 2020

Abstract
Despite years of ongoing interventions by multiple external and regional actors, the security situation in west Africa's Sahel region is dramatically deteriorating. In this introduction to the special section of the July 2020 issue of International Affairs, we zoom in on four major external international intervention actors (France, the United States, the European Union and the United Nations) in the Sahel region's escalating ‘security traffic jam’. We argue that the diversity of intervention actors makes the Sahel a paradigmatic case for exploring a set of often-overlooked constitutive intervention effects. By adding new temporal, relational and spatial dimensions to the notion of ‘constitutive effects’ as introduced by post-structuralists in the 1990s, we (re)launch constitutive effects as a conceptual framework for approaching the study of ongoing intervention engagements. From this perspective, and as further illustrated in this special section, intervention continuity and escalation cannot be explained simply with reference to frameworks of ‘success’ or ‘failure’, but require a broader conceptualization of effects, including how specific threat perceptions, rationales and problematizations get constituted and consolidated through and during ongoing intervention practice. Contributions to this special section each unpack a diverse set of constitutive effects including the contested performance of security actorness, the (un)making of security alliances and partnerships, logics of choices produced by ongoing intervention practices, as well as the constitution of conditions for continual international involvement.
The bitter harvest of French interventionism in the Sahel
Authors: Guichaoua Yvan 
Published: July 2020

Abstract
This article studies the bitter diplomatic sequence arising in the fall of 2019 between France and the Sahelian countries where France has been conducting military operations since 2013. Far from being just one more hiccup in the troubled relations between France and its former colonies, the article interprets this sequence as a constitutive effect of French protracted military presence in the Sahel. Specifically, it argues that although France has a rather clear security-driven agenda, its operational moves produced by bureaucratic thinking are questioned by influential sections of Sahelian public opinions who frame the French military presence as a deeply political issue over their country's sovereignty. In addition, being the de facto military guarantor of the security of Sahelian regimes, France constrains the domestic political conversation through the ‘red lines’ it imposes on actors. This externally-induced distortion of the domestic political landscape eventually places Sahelian authorities in front of a dilemma. Pleasing their foreign patrons might cost them the support of the section of public opinion most attached to national sovereignty, and expose them to nationalist entrepreneurs.
The anatomy of a distributed predictive modeling framework: online learning, blockchain network, and consensus algorithm
Authors: Kuo Tsung-Ting 
Published: July 2020

Abstract

Objective
Cross-institutional distributed healthcare/genomic predictive modeling is an emerging technology that fulfills both the need of building a more generalizable model and of protecting patient data by only exchanging the models but not the patient data. In this article, the implementation details are presented for one specific blockchain-based approach, ExplorerChain, from a software development perspective. The healthcare/genomic use cases of myocardial infarction, cancer biomarker, and length of hospitalization after surgery are also described.

Materials and Methods
ExplorerChain’s 3 main technical components, including online machine learning, metadata of transaction, and the Proof-of-Information-Timed (PoINT) algorithm, are introduced in this study. Specifically, the 3 algorithms (ie, core, new network, and new site/data) are described in detail.

Results
ExplorerChain was implemented and the design details of it were illustrated, especially the development configurations in a practical setting. Also, the system architecture and programming languages are introduced. The code was also released in an open source repository available at https://github.com/tsungtingkuo/explorerchain.

Discussion
The designing considerations of semi-trust assumption, data format normalization, and non-determinism was discussed. The limitations of the implementation include fixed-number participating sites, limited join-or-leave capability during initialization, advanced privacy technology yet to be included, and further investigation in ethical, legal, and social implications.

Conclusion
This study can serve as a reference for the researchers who would like to implement and even deploy blockchain technology. Furthermore, the off-the-shelf software can also serve as a cornerstone to accelerate the development and investigation of future healthcare/genomic blockchain studies.