bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypercompact stellar clusters: morphological renditions and spectrophotometric models
Authors: Lena D , Jonker P G , Rauer J P , Hernandez S , Kostrzewa-Rutkowska Z 
Published: April 2020

ABSTRACT
Numerical relativity predicts that the coalescence of a black hole (BH) binary causes the newly formed BH to recoil, and evidence for such recoils has been found in the gravitational waves observed during the merger of stellar-mass BHs. Recoiling (super)massive BHs are expected to reside in hypercompact stellar clusters (HCSCs). Simulations of galaxy assembly predict that hundreds of HCSCs should be present in the halo of a Milky Way (MW)-type galaxy, and a fraction of those around the MW should have magnitudes within the sensitivity limit of existing surveys. However, recoiling BHs and their HCSCs are still waiting to be securely identified. With the goal of enabling searches through recent and forthcoming data bases, we improve over existing literature to produce realistic renditions of HCSCs bound to BHs with a mass of 105 M⊙. Including the effects of a population of blue stragglers, we simulate their appearance in Pan-STARRS and in forthcoming Euclid images. We also derive broad-band spectra and the corresponding multiwavelength colours, finding that the great majority of the simulated HCSCs fall on the colour–colour loci defined by stars and galaxies, with their spectra resembling those of giant K-type stars. We discuss the clusters properties, search strategies, and possible interlopers.
A new radio catalogue for M83: supernova remnants and H ii regions
Authors: Russell Thomas D , White Richard L , Long Knox S , Blair William P , Soria Roberto , Winkler P Frank 
Published: April 2020

ABSTRACT
We present a new catalogue of radio sources in the face-on spiral galaxy M83. Radio observations taken in 2011, 2015, and 2017 with the Australia Telescope Compact Array at 5.5 and 9 GHz have detected 270 radio sources. Although a small number of these sources are background extragalactic sources, most are either H ii regions or supernova remnants (SNRs) within M83 itself. Three of the six historical supernovae are detected, as is the very young remnant that had been identified in a recent study, which is likely the result of a supernova that exploded in the last ∼100 yr but was missed. All of these objects are generally fading with time. Confusion limits our ability to measure the radio emission from a number of the SNRs in M83, but 64 were detected in unconfused regions, and these have the approximate power-law luminosity function that has been observed in other galaxies. The SNRs in M83 are systematically smaller in diameter and brighter than those that have been detected at radio wavelengths in M33. A number of the radio sources are coincident with X-ray sources in M83; most of these coincident sources turn out to be SNRs. Our dual frequency observations are among the most sensitive to date for a spiral galaxy outside the Local Group; despite this we were not able to place realistic constraints on the spectral indices, and as a result, it was not possible to search for SNRs based on their radio properties alone.
Neutron star mergers and rare core-collapse supernovae as sources of r-process enrichment in simulated galaxies
Authors: van de Voort Freeke , Pakmor Rüdiger , Grand Robert J J , Springel Volker , Gómez Facundo A , Marinacci Federico 
Published: April 2020

ABSTRACT
We use cosmological, magnetohydrodynamical simulations of Milky Way-mass galaxies from the Auriga project to study their enrichment with rapid neutron capture (r-process) elements. We implement a variety of enrichment models from both binary neutron star mergers and rare core-collapse supernovae. We focus on the abundances of (extremely) metal-poor stars, most of which were formed during the first ∼Gyr of the Universe in external galaxies and later accreted on to the main galaxy. We find that the majority of metal-poor stars are r-process enriched in all our enrichment models. Neutron star merger models result in a median r-process abundance ratio, which increases with metallicity, whereas the median trend in rare core-collapse supernova models is approximately flat. The scatter in r-process abundance increases for models with longer delay times or lower rates of r-process-producing events. Our results are nearly perfectly converged, in part due to the mixing of gas between mesh cells in the simulations. Additionally, different Milky Way-mass galaxies show only small variation in their respective r-process abundance ratios. Current (sparse and potentially biased) observations of metal-poor stars in the Milky Way seem to prefer rare core-collapse supernovae over neutron star mergers as the dominant source of r-process elements at low metallicity, but we discuss possible caveats to our models. Dwarf galaxies that experience a single r-process event early in their history show highly enhanced r-process abundances at low metallicity, which is seen both in observations and in our simulations. We also find that the elements produced in a single event are mixed with ≈108 M⊙ of gas relatively quickly, distributing the r-process elements over a large region.
Gene expression dynamics are a proxy for selective pressures on alternatively polyadenylated isoforms
Authors: Levin Michal , Zalts Harel , Mostov Natalia , Hashimshony Tamar , Yanai Itai 
Published: April 2020

Abstract
Alternative polyadenylation (APA) produces isoforms with distinct 3′-ends, yet their functional differences remain largely unknown. Here, we introduce the APA-seq method to detect the expression levels of APA isoforms from 3′-end RNA-Seq data by exploiting both paired-end reads for gene isoform identification and quantification. We detected the expression levels of APA isoforms in individual Caenorhabditis elegans embryos at different stages throughout embryogenesis. Examining the correlation between the temporal profiles of isoforms led us to distinguish two classes of genes: those with highly correlated isoforms (HCI) and those with lowly correlated isoforms (LCI) across time. We hypothesized that variants with similar expression profiles may be the product of biological noise, while the LCI variants may be under tighter selection and consequently their distinct 3′ UTR isoforms are more likely to have functional consequences. Supporting this notion, we found that LCI genes have significantly more miRNA binding sites, more correlated expression profiles with those of their targeting miRNAs and a relative lack of correspondence between their transcription and protein abundances. Collectively, our results suggest that a lack of coherence among the regulation of 3′ UTR isoforms is a proxy for selective pressures acting upon APA usage and consequently for their functional relevance.
Protamine loops DNA in multiple steps
Authors: Ukogu Obinna A , Smith Adam D , Devenica Luka M , Bediako Hilary , McMillan Ryan B , Ma Yuxing , Balaji Ashwin , Schwab Robert D , Anwar Shahzad , Dasgupta Moumita , Carter Ashley R 
Published: April 2020

Abstract
Protamine proteins dramatically condense DNA in sperm to almost crystalline packing levels. Here, we measure the first step in the in vitro pathway, the folding of DNA into a single loop. Current models for DNA loop formation are one-step, all-or-nothing models with a looped state and an unlooped state. However, when we use a Tethered Particle Motion (TPM) assay to measure the dynamic, real-time looping of DNA by protamine, we observe the presence of multiple folded states that are long-lived (∼100 s) and reversible. In addition, we measure folding on DNA molecules that are too short to form loops. This suggests that protamine is using a multi-step process to loop the DNA rather than a one-step process. To visualize the DNA structures, we used an Atomic Force Microscopy (AFM) assay. We see that some folded DNA molecules are loops with a ∼10-nm radius and some of the folded molecules are partial loops—c-shapes or s-shapes—that have a radius of curvature of ∼10 nm. Further analysis of these structures suggest that protamine is bending the DNA to achieve this curvature rather than increasing the flexibility of the DNA. We therefore conclude that protamine loops DNA in multiple steps, bending it into a loop.
Visualizing ’omic feature rankings and log-ratios using Qurro
Authors: Fedarko Marcus W , Martino Cameron , Morton James T , González Antonio , Rahman Gibraan , Marotz Clarisse A , Minich Jeremiah J , Allen Eric E , Knight Rob 
Published: April 2020

Abstract
Many tools for dealing with compositional ‘ ’omics’ data produce feature-wise values that can be ranked in order to describe features’ associations with some sort of variation. These values include differentials (which describe features’ associations with specified covariates) and feature loadings (which describe features’ associations with variation along a given axis in a biplot). Although prior work has discussed the use of these ‘rankings’ as a starting point for exploring the log-ratios of particularly high- or low-ranked features, such exploratory analyses have previously been done using custom code to visualize feature rankings and the log-ratios of interest. This approach is laborious, prone to errors and raises questions about reproducibility. To address these problems we introduce Qurro, a tool that interactively visualizes a plot of feature rankings (a ‘rank plot’) alongside a plot of selected features’ log-ratios within samples (a ‘sample plot’). Qurro’s interface includes various controls that allow users to select features from along the rank plot to compute a log-ratio; this action updates both the rank plot (through highlighting selected features) and the sample plot (through displaying the current log-ratios of samples). Here, we demonstrate how this unique interface helps users explore feature rankings and log-ratios simply and effectively.
Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes
Authors: Frenster Joshua D , Kader Michael , Kamen Scott , Sun James , Chiriboga Luis , Serrano Jonathan , Bready Devin , Golub Danielle , Ravn-Boess Niklas , Stephan Gabriele , Chi Andrew S , Kurz Sylvia C , Jain Rajan , Park Christopher Y , Fenyo David , Liebscher Ines , Schöneberg Torsten , Wiggin Giselle , Newman Robert , Barnes Matt , Dickson John K , MacNeil Douglas J , Huang Xinyan , Shohdy Nadim , Snuderl Matija , Zagzag David , Placantonakis Dimitris G 
Published: April 2020

Abstract

Background
Glioma is a family of primary brain malignancies with limited treatment options and in need of novel therapies. We previously demonstrated that the adhesion G protein-coupled receptor GPR133 (ADGRD1) is necessary for tumor growth in adult glioblastoma, the most advanced malignancy within the glioma family. However, the expression pattern of GPR133 in other types of adult glioma is unknown.

Methods
We used immunohistochemistry in tumor specimens and non-neoplastic cadaveric brain tissue to profile GPR133 expression in adult gliomas.

Results
We show that GPR133 expression increases as a function of WHO grade and peaks in glioblastoma, where all tumors ubiquitously express it. Importantly, GPR133 is expressed within the tumor bulk, as well as in the brain-infiltrating tumor margin. Furthermore, GPR133 is expressed in both isocitrate dehydrogenase (IDH) wild-type and mutant gliomas, albeit at higher levels in IDH wild-type tumors.

Conclusion
The fact that GPR133 is absent from non-neoplastic brain tissue but de novo expressed in glioma suggests that it may be exploited therapeutically.
A Systematic Review on Balance Performance in Patients With Bilateral Vestibulopathy
Authors: Herssens Nolan , Verbecque Evi , McCrum Christopher , Meijer Kenneth , van de Berg Raymond , Saeys Wim , Vereeck Luc , Van Rompaey Vincent , Hallemans Ann 
Published: April 2020

Abstract

Objective
Patients with bilateral vestibulopathy (BVP) have severe balance deficits, but it is unclear which balance measures are best suited to quantify their deficits and approximate the diversity of their self-reports. The purpose of this study was to explore measures of balance control for quantifying the performance of patients with BVP related to different balance domains, allowing targeted assessment of response to intervention.

Methods
MEDLINE, Web of Science, and Embase were systematically searched on October 9, 2019. The Scottish Intercollegiate Guidelines Network checklist for case-control studies was applied to assess each individual study’s risk of bias. Standardized mean differences (SMD) were calculated based on the extracted numeric data and reported according to the type of sensory perturbation in the balance tasks.

Results
Twelve studies (1.3%) met the eligibility criteria and were analyzed, including data of 176 patients with BVP, 196 patients with unilateral vestibulopathy, and 205 healthy controls between 18 and 92 years old. In general, patients with BVP were either unable to maintain (or had reduced) balance during tasks with multisensory perturbations compared with healthy controls (range of mean SMD = 1.52–6.92) and patients with unilateral vestibulopathy (range of absolute mean SMD = 0.86–1.66).

Conclusions
During clinical assessment to quantify balance control in patients with BVP, tasks involving multisensory perturbations should be implemented in the test protocol.

Impact
As patients with BVP show difficulties with movement strategies, control of dynamics, orientation in space, and cognitive processing, clinicians should implement these aspects of balance control in their assessment protocol to fully comprehend the balance deficits in these patients.
The Influence of Early Exercise Postpartum on Pelvic Floor Muscle Function and Prevalence of Pelvic Floor Dysfunction 12 Months Postpartum
Authors: Tennfjord Merete Kolberg , Engh Marie Ellström , Bø Kari 
Published: April 2020

Abstract

Objective
There is limited knowledge on how exercise impacts the pelvic floor muscles (PFM) and prevalence of stress urinary incontinence (SUI) and pelvic organ prolapse (POP) postpartum. The purpose of this study was to investigate whether early onset of general exercise postpartum negatively affects the PFM and/or increases the risk of SUI and POP 12 months postpartum.

Methods
This study used a prospective cohort design. At 6 weeks postpartum, 57 women classified as exercisers (exercising ≥3 times at ≥30 min/wk) were compared with 120 nonexercisers (mean age = 29 years, SD = 4.3). Manometry was used to measure vaginal resting pressure, PFM strength, and PFM endurance, and symptoms of SUI and POP were assessed using questionnaires. Data were presented as standardized beta coefficients (B) and odds ratios (OR).

Results
No differences were found between exercisers (n = 57) and non-exercisers (n = 120) at 6 weeks postpartum on vaginal resting pressure (B = −0.04 [95% CI = −3.4 to 2.1]), PFM strength (B = 0.03 [95% CI = −4.7 to 7.4]), PFM endurance (B = −0.02 [95% CI = −59 to 46]), or symptoms of SUI (OR = 0.51 [95% CI = 0.25 to 1.1]) or POP (OR = 0.62 [95% CI = 0.26 to 1.5]) measured at 12 months postpartum. Adjusting for covariates, women with body mass index between 25 and 29.9 and &gt;30 were more likely to report SUI 12 months postpartum (OR = 2.2 [95% CI = 1.0 to 4.7] and OR = 3.3 [95% CI = 1.2 to 9.4], respectively). Women with physically strenuous occupations were more likely to report POP 12 months postpartum (OR = 3.0 [95% CI = 1.2 to 7.3]).

Conclusions
This study suggests that regular exercise 6 weeks postpartum has no negative effect on PFM function or on SUI or POP. Being overweight, however, was associated with more SUI, and women with physically strenuous occupations reported more POP.

Impact
Results from this study suggest that first-time mothers should be encouraged to start general exercise within the first 6 weeks after giving birth. Women at risk for PFD should be advised accordingly and potentially modifiable risk factors should be addressed prior to delivery.

Lay Summary
First-time mothers are encouraged to talk with a physical therapist about starting regular general exercise in the early postpartum weeks. Health care providers should advise patients on possible preventive measures for women at risk for PFD.
Sex-specific relationships between face memory and the N170 component in event-related potentials
Authors: Nowparast Rostami Hadiseh , Hildebrandt Andrea , Sommer Werner 
Published: April 2020

Abstract
At the group level, women consistently perform better in face memory tasks than men and also show earlier and larger N170 components of event-related brain potentials (ERP), considered to indicate perceptual structural encoding of faces. Here we investigated sex differences in the relationship between the N170 and face memory performance in 152 men and 141 women at group mean and individual differences levels. ERPs and performance were measured in separate tasks, avoiding statistical dependency between the two. We confirmed previous findings about superior face memory in women and a—sex-independent—negative relationship between N170 latency and face memory. However, whereas in men, better face memory was related to larger N170 components, face memory in women was unrelated with the amplitude or latency of the N170. These data provide solid evidence that individual differences in face memory within men are at least partially related to more intense structural face encoding.
The German family foundation: concept, legal framework, and taxation
Authors: Haag Maximilian , Tischendorf Michael 
Published: April 2020

Abstract
Most German foundations serve the common good. Nevertheless, setting up a private foundation in Germany has proven to be a valuable instrument in private wealth management and estate planning. About 5% of all German foundations are the so-called family foundations with the purpose of serving the interests of one or more families. There are numerous possible areas of application, such as business succession, asset protection, estate planning, and/or use of tax advantages. This article is intended to describe the concept of the German family foundation, its establishment, constitution, and termination, as well as its taxation, in order to provide an overview of its advantages, disadvantages, and possible applications. The German non-profit foundation shall not be discussed.
Managing older patients with cancer
Authors: Robinson Lauren , Xavier Neena A. 
Published: April 2020

ABSTRACT
With the growing population of adults over age 70 years, clinicians must know how to care appropriately for the increasing number of older patients with cancer. Although older adults have higher rates of surgical complications and chemotherapy-related toxicity, they should not be excluded from treatment opportunities based on age alone. Rather, patients should be assessed for fitness, or functional age, for a more accurate estimation of how they will tolerate treatment. This article discusses considerations clinicians should take into account when developing effective treatment plans that do not compromise quality of life for older patients with cancer.
Anticipating the management of Streptococcus agalactiae infective endocarditis
Authors: Schalla Gregory , Grant Michael 
Published: April 2020

ABSTRACT
A patient who presented after falling out of bed had signs of right-sided stroke, which, after imaging, was suspicious for embolism with cardiac origin. Further investigation revealed a large aortic valve vegetation with mild aortic insufficiency, and the patient eventually developed heart failure requiring surgical intervention. Infective endocarditis is slowly becoming more prevalent, and clinicians should have a high index of suspicion when patients present with common complications of this disease, such as valvular dysfunction, heart failure, or stroke. Early diagnosis has been shown to reduce time to appropriate antibiotic treatment and definitive care, which can lead to better outcomes.
Spinal Surgery for Parkinson Disease With Camptocormia
Authors: Park Hyung-Youl , Ha Kee-Yong , Kim Young-Hoon , Oh In-Soo , Chang Dong-Gune , Kim Sang-Il , Jeon Woong-Ki , Kim Geon-U. 
Published: April 2020

Study design:
A propensity score–matched cohort study.

Objective:
The objective of this study was to compare the radiologic and clinical outcomes of camptocormia in Parkinson disease (PD) with degenerative sagittal imbalance (DSI) patients.

Summary of Background Data:
Camptocormia in PD and DSI could be characterized by a dynamic deformity. However, no study has directly evaluated the outcomes of patients with camptocormia and DSI.

Methods:
Thirteen consecutive PD patients undergoing surgical correction for camptocormia were matched in a 1-to-2 format with 26 patients in the DSI group by propensity score–matching. Radiologic outcomes, including paravertebral muscle changes, and clinical outcomes were compared between the 2 groups. The rate of proximal junctional problems and reoperations were assessed.

Results:
PD patients with camptocormia had significantly greater preoperative coronal and sagittal malalignments (29.9 vs. 16.9 mm, P=0.019; 142.8 vs. 64.4 mm, P=0.0001, respectively) and weakness of paravertebral muscles compared with the DSI patients. Regarding the clinical outcomes, reoperations were significantly higher in the camptocormia group, compared with the DSI group (53.8% vs. 7.7%, P=0.001). Moreover, proximal junctional failure was developed in 8 patients in the camptocormia group, while 1 patient in the DSI group (61.5% vs. 3.8%, P=0.0001). In subgroup analysis, independent risk factors for the proximal junctional failure were the total fusion levels (hazard ratio=0.26, P=0.018) and the degree of fatty changes of the paravertebral muscles (hazard ratio=1.15, P=0.048).

Conclusions:
PD patients undergoing spinal surgery for camptocormia had global malalignment and higher rates of complications compared with DSI patients. Patients should be appropriately counseled regarding the increased risk of operative complications and closely followed for incipient failure.
Deciphering skin re-pigmentation patterns in vitiligo: an update on the cellular and molecular events involved
Authors: Lei Tie-Chi , Hearing Vincent J. 
Published: April 2020

Abstract
Current treatment of vitiligo is still a great challenge, since most cases of vitiligo have variable re-pigmentation outcomes due to their unpredictable responses to existing therapeutic regimens. There is an urgent need to identify this re-pigmentation process and to develop novel therapies. This review illustrates the most current research and latest understanding of vitiligo skin re-pigmentation and related regulatory mechanisms. Literature was collected from PubMed until January 2020, using the search terms including “vitiligo,” “re-pigmentation,” “phototherapy,” “narrow-band ultraviolet B, ” “excimer,” “fractional carbon dioxide laser,” and “melanocyte stem cells.” Literature was mainly derived from English articles. Article type was not limited. Emerging evidence suggests that patients with vitiligo present various re-pigmentation patterns following ultraviolet B phototherapy, which relies on different cell reservoirs from the perilesional margins and/or from uninvolved hair follicles to replenish functional melanocytes that are lost in vitiliginous skin. The following events are likely to be involved in this re-pigmentation process, including: 1) changes in the paracrine secretion and distribution of transforming growth factor-β1 in the bulge area and in the epidermis; 2) the enhanced transfer of dermal pro-melanogenic growth factors to the epidermis; and 3) the induction of a C-X-C motif chemokine ligand (CXCL) 12-enriched micro-environment that efficiently recruits CXCR4- or CXCR7-positive melanocytes. Ongoing studies on the cellular and molecular events underlying vitiligo re-pigmentation will help design new therapeutic strategies to improve treatment outcomes.