bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current status of ambulatory blood pressure monitoring in Asian countries: A report from the HOPE Asia Network
Authors: Shin Jinho , Kario Kazuomi , Chia Yook‐Chin , Turana Yuda , Chen Chen‐Huan , Buranakitjaroen Peera , Divinagracia Romeo , Nailes Jennifer , Hoshide Satoshi , Siddique Saulat , Sison Jorge , Soenarta Arieska Ann , Sogunuru Guru Prasad , Tay Jam Chin , Teo Boon Wee , Zhang Yu‐Qing , Park Sungha , Van Minh Huynh , Kabutoya Tomoyuki , Verma Narsingh , Wang Tzung‐Dau , Wang Ji‐Guang 
Published: November 2019

AbstractAmbulatory blood pressure monitoring (ABPM) can measure 24‐hour blood pressure (BP), including nocturnal BP and diurnal variations. This feature of ABPM could be of value in Asian populations for preventing cardiovascular events. However, no study has yet investigated regarding the use of ABPM in actual clinical settings in Asian countries/regions. In this study, 11 experts from 11 countries/regions were asked to answer questionnaires regarding the use of ABPM. We found that its use was very limited in primary care settings and almost exclusively available in referral settings. The indications of ABPM in actual clinical settings were largely similar to those of home BP monitoring (HBPM), that is, diagnosis of white‐coat or masked hypertension and more accurate BP measurement for borderline clinic BP. Other interesting indications, such as nighttime BP patterns, including non‐dipper BP, morning BP surge, and BP variability, were hardly adopted in daily clinical practice. The use of ABPM as treatment guidance for detecting treated but uncontrolled hypertension in the Asian countries/regions didn't seem to be common. The barrier to the use of ABPM was primarily its availability; in referral centers, patient reluctance owing to discomfort or sleep disturbance was the most frequent barrier. ABPM use was significantly more economical when it was reimbursed by public insurance. To facilitate ABPM use, more simplified indications and protocols to minimize discomfort should be sought. For the time being, HBPM could be a reasonable alternative.
Is periodontitis a risk indicator for gastrointestinal cancers? A meta‐analysis of cohort studies
Authors: Zhang Yun , Sun Chenyu , Song Evelyn J. , Liang Mingming , Shi Tingting , Min Min , Sun Yehuan 
Published: November 2019

AbstractObjectiveTo evaluate the association between periodontitis and the incidence and mortality of gastrointestinal cancer.MethodA comprehensive literature search was conducted to identify all relevant studies published prior to April 2019 according to the established inclusion criteria. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a random‐effects model.ResultsWe identified 10 studies with 26 estimates of the relationship between periodontitis and gastrointestinal cancer. The HR for the incidence of gastrointestinal cancer in periodontitis was 1.23 (95% CI: 1.10–1.37). Subgroup analyses showed that periodontitis was associated with an increased risk of gastrointestinal cancers in prospective cohort studies and high–quality studies, North American individuals, and individuals 18 years or older, as well as when the dental status was self‐reported and when the study was adjusted for smoking. A meta‐analysis of nine reports demonstrated that periodontitis was associated with increased mortality from gastrointestinal cancer (HR = 1.59, 95% CI: 1.16–2.16). Additionally, periodontitis was associated with mortality from pancreatic cancer (HR = 2.20, 95% CI: 1.44–3.37); thus, periodontitis may be a risk factor for pancreatic cancer.ConclusionOur meta‐analysis demonstrated that periodontitis may be a risk factor for gastrointestinal cancers. Additional prospective cohort studies are warranted to confirm these findings.
Microbial composition of Korean kefir and antimicrobial activity of Acetobacter fabarum DH1801
Authors: Kim Dong‐Hyeon , Kim Hyunsook , Seo Kun‐Ho 
Published: November 2019

AbstractKefir is a probiotic dairy product containing multiple species of lactic acid bacteria, acetic acid bacteria, and yeast, with varying microbial composition depending on geographical origin. In the present study, we characterized the acetic acid bacterial population in Korean kefir by next‐generation sequencing‐based community analysis and isolated a novel acetic acid bacterial strain, Acetobacter fabarum DH1801. To evaluate its potential application in the food industry, the antimicrobial activity of A. fabarum DH1801 against seven foodborne pathogens (Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, Cronobacter sakazakii, Salmonella Enteritidis, enterotoxigenic Escherichia coli, and Shigella flexneri) was analyzed by growth curve analysis. Remarkably, the culture filtrate of the novel isolate inhibited the growth of all seven pathogenic bacteria in a dose‐dependent manner, which was superior to acetic acid solution of same pH value. Our findings suggest that the A. fabarum DH1801 strain forms a protective barrier during kefir fermentation against contamination by foodborne pathogens.
Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype
Authors: Huang Wen‐Chih , Liau Jau‐Yu , Jeng Yung‐Ming , Liu Kao‐Lang , Lin Chia‐Nan , Song Hsiang‐Lin , Tsai Jia‐Huei 
Published: November 2019

AbstractBackground and AimThe clinicopathologic features of hepatocellular adenoma in Asian populations have been poorly defined. The study aimed to characterize this rare entity in a single institution in Taiwan.MethodsIn total, 45 hepatocellular adenomas from 1995 to 2018 were included and sent for pathologic review and molecular subtyping.ResultsThe numbers of patients with hepatocellular adenoma has doubled in the recent decade. Surprisingly, men outnumbered women in our cohort (n = 26, 58% vs N = 19, 42%). A collection of clinical information revealed that overweight/obesity accounts for most of the associated conditions of hepatocellular adenoma. Only three women took oral contraceptives. There were 34 inflammatory (75%), three LFABP‐negative (7%), four β‐catenin activated (9%), and four unclassified (9%) hepatocellular adenomas. Ten inflammatory hepatocellular adenomas demonstrated strong and homogeneous glutamine synthetase staining and were thus also β‐catenin activated. Notably, overweight and obesity were significantly associated with inflammatory hepatocellular adenoma than other subtypes (P = .029 and .056, respectively) and were strongly correlated with steatosis in background liver (P = .028 and.007, respectively). Malignant transformation (four borderline tumors and two hepatocellular carcinomas) was identified in six adenomas (two women and four men). All six hepatocellular adenomas with malignancy were β‐catenin activated; β‐catenin activation could serve as a biomarker for malignant progression.ConclusionsThe clinicopathologic features of hepatocellular adenoma in Taiwan are distinct from those reported in Western countries. Rare oral contraceptive usage and an emerging epidemic of overweight/obesity in Taiwan provides new insights into the pathogenesis of hepatocellular adenoma.
Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta‐analysis of randomized controlled trials
Authors: Zheng Ting , Wang Xin , Chen Zongran , He Anqi , Zheng Zicheng , Liu Gang 
Published: November 2019

AbstractBackground and AimAminosalicylic acids are recognized to be the first‐line treatment options for ulcerative colitis. Currently, the effectiveness of curcumin as an adjuvant treatment in ulcerative colitis has been investigated, which was still controversial. This study aimed to systematically review and meta‐analyze the efficacy and safety of curcumin as an adjuvant treatment in ulcerative colitis.MethodsThe PubMed, EMBASE, and Cochrane Library databases were searched from original to July 2019, and relevant randomized controlled clinical trials were enrolled and analyzed. The primary outcomes were clinical and endoscopic remission; meanwhile, the secondary outcomes were clinical and endoscopic improvement. Subgroup analyses of doses, delivery way, form, and intervention time of curcumin were also conducted.ResultsSix randomized controlled clinical trials with a total of 349 patients were included. Eligible trials suggested that adjuvant curcumin treatment in ulcerative colitis was effective in inducing clinical remission (odds ratio [OR] = 5.18, 95% confidence interval [CI]: 1.84–14.56, P = 0.002), endoscopic remission (OR = 5.69, 95% CI: 1.28–25.27, P = 0.02), and endoscopic improvement (OR = 17.05, 95% CI: 1.30–233.00, P = 0.03), but not in clinical improvement (OR = 4.79, 95% CI: 1.02–22.43, P = 0.05). We can see the potential advantages in large dosage, topical enema, special drug form, and longer duration from the enrolled studies. There were no severe side effects reported.ConclusionsCurcumin, as an adjuvant treatment of mesalamine, was proved to be effective and safe in ulcerative colitis. Better efficacy can be achieved with suitable dose, delivery way, formation, and intervention time, which needs further study to verify.
Clinical features and etiology of patients with erythema ab igne: A retrospective multicenter study
Authors: Ozturk Murat , An Isa 
Published: November 2019

AbstractObjectiveThe aim of this study was to investigate the demographic and clinical features, etiology of patients with erythema ab igne (EAI) who presented to our clinics.Materials and MethodsThe present study was conducted on 71 patients who were admitted to our dermatology clinics between April 2018 and June 2019 and were diagnosed with EAI by clinical or histopathological examination. Age, gender, localization of lesions, and etiologic causes of lesions were recorded.ResultsOf the 71 patients, 48 (67.6%) were women and 23 (32.4%) were men. The mean age of the patients was 28.6 ± 10.4 years. Most of the lesions were localized (60.6%, n = 43) on the anterior aspect of both legs. Among the etiological reasons, 53 (74.6%) patients had exposure to heater, 14 (19.7%) patients had exposure to stove, 2 (2.8%) patients had laptop use, 1 (1.4%) patient had tandoor contact, and 1 (1.4%) patient had exposure to hot water bag. One patient was diagnosed with bullous EAI.ConclusionIn conclusion, EAI was also more common in females and lower extremities, which is in accordance with the literature. However, the mean age of occurrence in our study is younger when compared with that in the literature. One case of EAI due to the use of tandoor in our study has not been reported previously. It should be kept in mind that bullous EAI may develop in patients with diabetes mellitus.
Packs, Troops and Herds: Prosocial Cooperatives and Innovation in the New Normal
Authors: Muñoz Pablo , Kimmitt Jonathan , Dimov Dimo 
Published: November 2019

AbstractProsocial organizations are emerging to tackle the effects of a New Normal. As they navigate its fragile and liquid institutional membranes, they prioritize cooperative forms of governance. These forms allow for collaboration and democratic decision‐making necessary for the development of innovative solutions in this new context. At the same time, the high coordination costs of cooperatives lead to significant market pressures. Therefore, understanding when and under what conditions these new cooperatives innovate and strive is important as it provides insight into whether and how these ventures can become a viable alternative in this changing landscape. Using configurational analyses of organizational enablers leading to innovation in 40 entrepreneurial cooperatives, we identify three approaches: Attentive Pack, Eclectic Troop, and Wandering Herd, showing that innovative outcomes can indeed emerge under traditional cooperative features emphasizing collectivism. However, the pursuit of higher novelty requires a shift to more individualistic, business‐as‐usual, approaches. The New Normal does indeed enhance entrepreneurial activity, but of a different kind comprising novel sets of antecedents and outcomes, which we show can easily become the new dominant form of venturing required in this new context.
Comparative Effect of Glass Fiber and Nano‐Filler Addition on Denture Repair Strength
Authors: Abushowmi Tahani H. , AlZaher Zahra A. , Almaskin Danah F. , Qaw Masoumah S. , Abualsaud Reem , Akhtar Sultan , Al‐Thobity Ahmad M. , Al‐Harbi Fahad A. , Gad Mohammed M. , Baba Nadim Z. 
Published: November 2019

AbstractPurposeTo evaluate and compare the effects of glass fiber (GF), Zirconium oxide nanoparticles (nano‐ZrO2), and silicon dioxide nanoparticles (nano‐SiO2) addition on the flexural strength and impact strength of repaired denture base material.Materials and MethodsHeat‐polymerized acrylic resin specimens were fabricated. All specimens were sectioned centrally and beveled creating 2.5 mm repair gap except for 10 controls. Specimen grouping (n = 10/group) was done according to filler concentration of 0%, 0.25%, 0.5%, and 0.75% of auto‐polymerized acrylic powder. Modified resin was mixed, packed in the repair gap, polymerized, finished and polished. Three‐point bending test and Charpy type impact testing were done. Data were analyzed using one‐way‐ANOVA and Post‐Hoc Tukey test (α = 0.05).ResultsAll additives significantly increased flexural strength and impact strength (p < 0.05). Within the modified subgroups, no significant differences were found for GF. Significant increase for nano‐ZrO2 and significant decrease for nano‐SiO2 as the concentration of additive increased were noted for both flexural strength and impact strength. Highest flexural strength was found with 0.75%‐nano‐ZrO2 (69.59 ± 2.52MPa) and the lowest was found with 0.75%‐nano‐SiO2 (53.82 ± 3.10MPa). The 0.25%‐nano‐SiO2 showed the highest impact strength value (2.54 ± 0.21 kJ/m2) while the lowest impact strength value was seen with 0.75%‐nano‐SiO2 (1.54 ± 0.17 kJ/m2).ConclusionNano‐filler effect was concentration dependent and its addition to repair resin increased the flexural and impact strengths. The incorporation of 0.75%‐ZrO2 or 0.25%‐SiO2 into repair resin proved to be a promising technique to enhance repair strength and avoid repeated fractures.
The contribution of texture contrasts and combinations to food acceptance across cultures
Authors: Pellegrino Robert , Cheon Bobby K. , Forde Ciarán G. , Oleszkiewicz Anna , Pieniak Michal , Luckett Curtis R. 
Published: November 2019

AbstractTexture has long been considered an important attribute for food acceptance. However, which specific textural characteristics contribute to overall acceptance of a food is not well understood. It has been suggested that texture contrasts and combinations are a universal feature in giving foods a desirable texture, yet this notion is largely based upon anecdotal data. This study uses multiple survey research methods to assess the importance of texture contrast and combinations across cultures (Poland, U.S.A., and Singapore). Participants (N = 288) completed a survey that included overt measures of food texture contrast importance as well as free response questions regarding texture. The overall importance of texture for food liking was not different across the populations. However, the participants from Singapore and Poland gave more importance to a desirable food having multiple textures than the U.S.A. cohort. When looking at free responses, participants were twice as likely to mention combinations (multiple textures) with a texture contrast when describing foods they liked, in comparison to foods they disliked. This was observed across all three cultures. However, the type and quantity of texture terms used within combinations were different among cultures. For instance, Singaporeans enjoyed more texturally diverse food combinations than the other two cultures. These findings highlight the importance of texture contrasts and combinations in three distinct cultures.
Mother‐to‐child transmission of hepatitis B: What more needs to be done to eliminate it around the world?
Authors: Nayagam Shevanthi , Shimakawa Yusuke , Lemoine Maud 
Published: November 2019

AbstractMother‐to‐child transmission (MTCT) of hepatitis B virus (HBV) is a key component of the hepatitis B burden worldwide. Despite its efficacy to prevent HBV transmission, infant vaccination is not enough to control HBV MTCT. Additional efforts are urgently needed to evaluate and scale‐up preventive strategies especially in endemic countries, which are most affected. This review highlights the efficacy and barriers of the currently validated measures for the prevention of HBV MTCT and proposes alternatives adapted to resource‐limited settings to eventually achieve HBV elimination worldwide.
Phase I study of KRP‐116D, a 50% w/w dimethyl sulfoxide aqueous solution, on the systemic absorption from bladder by intravesical instillation in healthy Japanese subjects
Authors: Shimada Hideyo , Yono Makoto , Hojo Yuya , Hamamura Yuka , Ootsuki Atsushi 
Published: November 2019

AbstractObjectiveThis was a single‐institution, single‐dose, single‐arm phase 1 study in healthy adult males to evaluate the safety and absorption of dimethyl sulfoxide (DMSO) from the bladder into the body when KRP‐116D (a 50% w/w DMSO solution) was intravesically administered and allowed to remain in the bladder for 15 minutes.MethodsSix healthy adult males were enrolled in this study. KRP‐116D (50 mL) was instilled directly into the bladder via a catheter where it was allowed to remain for 15 minutes under lidocaine anesthesia in accordance with the usage of RIMSO‐50 (50% w/w DMSO solution) approved in the USA. The residual DMSO solution in the bladder was collected 15 minutes after instillation. The concentrations of DMSO in the plasma and the recovered solution were analyzed by a validated high‐performance liquid chromatography (HPLC) method. The concentration in the residual DMSO solution was multiplied by the solution volume and divided by the dosage to calculate the recovery rate of DMSO.ResultsPlasma DMSO was detected in one of six subjects, and in the remaining five subjects DMSO was not detected (<19.6 μg/mL). The recovery rate of DMSO from the bladder was 60.7% to 93.7%. The only drug‐related adverse event was breath odor (garlic‐like breath) observed in four of six subjects (66.7%).ConclusionAbsorption of DMSO from the bladder was low (16.3%), and the systemic exposure was limited. Most of the DMSO was recovered from the bladder. KRP‐116D 50 mL was well tolerated and safe.
Roseocin, a novel two‐component lantibiotic from an actinomycete
Authors: Singh Mangal , Chaudhary Sandeep , Sareen Dipti 
Published: November 2019

AbstractLantibiotics are lanthionine ring containing natural products that belong to the class of ribosomally synthesized and posttranslationally modified peptides (RiPPs). Recent expansion in the availability of microbial genome data and in silico analysis tools have accelerated the discovery of these promising alternatives to antibiotics. Following the genome‐mining approach, a biosynthetic gene cluster for a putative two‐component lantibiotic, roseocin, was identified in the genome of an Actinomycete, Streptomyces roseosporus NRRL 11379. Posttranslationally modified lanthipeptides of this cluster were obtained by heterologous expression of the genes in Escherichia coli, and were in vitro reconstituted to their bioactive form by exploiting commercial proteases like endoproteinase GluC, and proteinase K. The two peptides displayed synergistic antimicrobial activity against Gram‐positive bacteria including the WHO high‐priority pathogens, MRSA and VRE. Structural characterization confirmed the installation of four (methyl)lanthionine rings with an indispensable disulfide bond in the α‐peptide, and six (methyl)lanthionine rings in the β‐peptide, by a single promiscuous lanthionine synthetase, RosM. Roseocin is the first two‐component lantibiotic from a non‐Firmicute, with extensive lanthionine bridging.
The association between visual impairment and fatigue: a systematic review and meta‐analysis of observational studies
Authors: Schakel Wouter , Bode Christina , Elsman Ellen B M , van der Aa Hilde P A , de Vries Ralph , van Rens Gerardus H M B , van Nispen Ruth M A 
Published: November 2019

AbstractPurposeThe aim was to compare fatigue levels between patients with visual impairment and controls with normal sight and to examine the association between fatigue and vision loss severity.MethodsA systematic literature search was performed using databases of PubMed, Embase, PsycINFO and Cochrane to identify observational studies with outcomes related to fatigue (e.g. vitality subscale of the Short‐Form 36, Fatigue Assessment Scale). A meta‐analysis was performed using standardised mean differences (SMDs) and odds ratios (OR) to quantitatively summarise the association between visual impairment and fatigue. Sources of heterogeneity were explored by subgroup and sensitivity analyses. Study quality was assessed with the Newcastle‐Ottawa scale.ResultsAfter reviewing 4477 studies, 22 studies with a total of 40 004 participants were included, of which 18 contributed to meta‐analysis. Among these, eight were assessed as moderate quality studies and 10 as high quality studies. Pooled analysis involving 2500 patients and 8395 controls showed higher fatigue severity levels (S.M.D. = −0.36, 95% CI −0.50 to −0.22, 14 studies) among visually impaired patients compared to normally sighted controls. This effect size was small and persisted in sensitivity analyses that involved study quality, fatigue assessment tools and visual acuity data. Furthermore, pooled analysis of four studies including 2615 patients and 5438 controls showed a significant association between visual impairment and fatigue (OR = 2.61, 95% CI 1.69 to 4.04). Secondary meta‐analysis of four studies showed no significant difference in fatigue severity (S.M.D. = 0.01, 95% CI −0.37 to 0.39) between patients with moderate visual impairment and patients with severe visual impairment or blindness.ConclusionsCurrent moderate to high quality evidence suggest that patients with visual impairment experience more severe fatigue symptoms than persons with normal sight. However, a limited number of available studies indicates that fatigue is not associated with severity of vision loss. Future studies are required to determine which factors and underlying mechanisms may explain the association between visual impairment and fatigue. Discussing fatigue at an early stage and developing intervention options for vision‐related fatigue should be considered within the field of low vision rehabilitation.
Public Communication as a Tool to Implement Environmental Policies
Authors: de Vries Gerdien 
Published: November 2019

AbstractClimate change is one of the greatest challenges of our times. We humans must change our behavior in the short run to mitigate the effects of climate change in the long run. Policymakers develop environmental policies to motivate this behavioral change. However, people may nonetheless fail to change to more sustainable practices, defeating the effectiveness of environmental policies. Public communications, such as mass media campaigns, can enhance compliance with environmental policies, but they have not yet lived up to their potential. In this contribution, I propose that environmental communication would be more effective if public communicators took account of the (often counterintuitive) social and psychological processes that influence sustainable behaviors. I present research evidence of the impact of cognitive biases (discounting, control perceptions, optimism bias, denial, defensive avoidance, and reactance), emotions (fear and hope), and expectations (about the intentions of the communication source and other people's environmental behaviors) on the power of environmental public communication as a tool to promote sustainable behaviors. If social and psychological processes are neglected in the design of environmental public communications, messages can backfire and achieve the opposite of what was intended. To improve environmental communications, I propose three communication design suggestions: keep it simple, balance the message, and provide an action perspective.