bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea
Authors: Jeng Jing‐Yi , Ceriani Federico , Hendry Aenea , Johnson Stuart L. , Yen Piece , Simmons Dwayne D. , Kros Corné J. , Marcotti Walter 
Published: October 2019

Key points
Outer hair cells (OHCs) enhance the sensitivity and the frequency tuning of the mammalian cochlea.
Similar to the primary sensory receptor, the inner hair cells (IHCs), the mature functional characteristics of OHCs are acquired before hearing onset.
We found that OHCs, like IHCs, fire spontaneous Ca2+‐induced action potentials (APs) during immature stages of development, which are driven by CaV1.3 Ca2+ channels.
We also showed that the development of low‐ and high‐frequency hair cells is differentially regulated during pre‐hearing stages, with the former cells being more strongly dependent on experience‐independent Ca2+ action potential activity.
AbstractSound amplification within the mammalian cochlea depends upon specialized hair cells, the outer hair cells (OHCs), which possess both sensory and motile capabilities. In various altricial rodents, OHCs become functionally competent from around postnatal day 7 (P7), before the primary sensory inner hair cells (IHCs), which become competent at about the onset of hearing (P12). The mechanisms responsible for the maturation of OHCs and their synaptic specialization remain poorly understood. We report that spontaneous Ca2+ activity in the immature cochlea, which is generated by CaV1.3 Ca2+ channels, differentially regulates the maturation of hair cells along the cochlea. Under near‐physiological recording conditions we found that, similar to IHCs, immature OHCs elicited spontaneous Ca2+ action potentials (APs), but only during the first few postnatal days. Genetic ablation of these APs in vivo, using CaV1.3−/− mice, prevented the normal developmental acquisition of mature‐like basolateral membrane currents in low‐frequency (apical) hair cells, such as IK,n (carried by KCNQ4 channels), ISK2 and IACh (α9α10nAChRs) in OHCs and IK,n and IK,f (BK channels) in IHCs. Electromotility and prestin expression in OHCs were normal in CaV1.3−/− mice. The maturation of high‐frequency (basal) hair cells was also affected in CaV1.3−/− mice, but to a much lesser extent than apical cells. However, a characteristic feature in CaV1.3−/− mice was the reduced hair cell size irrespective of their cochlear location. We conclude that the development of low‐ and high‐frequency hair cells is differentially regulated during development, with apical cells being more strongly dependent on experience‐independent Ca2+ APs.
Laminar Heat Transfer of Gas-Liquid Segmented Flows in Circular Ducts With Constant Wall Temperature
Authors: Alrbee K. , Muzychka Y. S. , Duan X. 
Published: October 2019

Abstract
Laminar heat transfer of gas-liquid Taylor flow in circular tubes is considered. Previous studies have found that introducing a gas phase into a flow stream of a liquid phase significantly increases the heat transfer rate. Other studies considered the effect of slug length on heat transfer rates. The present study’s aim is to demonstrate heat transfer enhancement due to the shortening of liquid slug lengths in a segmented flow and to further validate a model previously developed by the second author. An experimental setup was assembled using mini scale horizontal tube in which the two phase fluid flow is heated under constant wall temperature. New experimental data for gas-liquid Taylor flow in mini scale were carefully obtained using 1 cSt silicone oil which was segmented by air. The experiments were performed with a liquid fraction maintained constant at 0.5 and Reynolds numbers from 50 to 320. In the present work, it is shown that for constant wall temperature, the dimensionless mean wall flux and Nusselt number have been increased by a factor of two at the upper limit of laminar flow which was considered with ReD = 320, when the slug aspect ratio LS/D equal to 10. On other hand the enhancement becomes three times at the same limit of flow when slug aspect ratio has reduced to 1.25 which almost approaches the tube diameter.
Numerical Study on Gas-Yield Power-Law Fluid in T-Junction Minichannel
Authors: Ihmoudah Abdalsalam , Awad Mohamed M. , Rahman Aziz , Butt Stephen D. 
Published: October 2019

Abstract
In this study, a computational examination of Taylor bubbles was performed for gas/non-Newtonian fluid two-phase flows developed in a minichannel T-junction mixer with a hydraulic diameter of 1 mm. The investigations employed three separate aqueous xanthan gum solutions at concentrations of 0.05, 0.1 and 0.15 w/w, which are referred to as non-Newtonian (yield power-law) fluids. The effective concentration of the xanthan gum solutions and superficial velocity of the inlet liquid phase on the length, velocity, and shape of the Taylor bubbles was studied using the ANSYS FLUENT 19 software package. The simulation results show an increase in bubble velocity with increasing film thickness, particularly in solutions of higher viscosity XG-0.15%. Furthermore, bubble lengths decreased as the xanthan gum concentrations increased, but bubble shapes underwent alterations when the concentrations increased. Another interesting result of the tests shows that when the liquid inlet velocity increases, bubble lengths decrease during lower liquid superficial velocity, whereas during higher velocities, they change only slightly after increases in concentration. Finally, with increasing XG concentration, the liquid film thickness around the bubble increased. The results show good agreement with correlations after modifying a capillary number (Ca*) for non-Newtonian liquids in all cases.
Sediment routing from shelf to basin floor in the Quaternary Golo System of Eastern Corsica, France, western Mediterranean Sea
Authors: Sweet Michael L. , Gaillot Gwladys T. , Jouet Gwenael , Rittenour Tammy M. , Toucanne Samuel , Marsset Tania , Blum Michael D. 
Published: October 2019

Abstract
How and when sediment moves from shallow marine to deep-water environments is an important and poorly understood control on basin-scale sediment dispersal patterns, the evolution of continental margins, and hydrocarbon exploration in deep-water basins. The Golo River (Eastern Corsica, France), its delta, canyons, and fans provide a unique opportunity to study sediment routing from source to sink in a relatively compact depositional system. We studied this system using an array of high-frequency seismic data, multi-beam bathymetry, and five cores for lithology and age control.
Movement of sediment to deep water was controlled by interactions between the Golo River, the Golo Delta, and shelf-penetrating submarine canyons. Sediment moved to deep water when lobes of the Golo Delta prograded to the heads of these canyons, or when the Golo River itself flowed directly into one of them. Sand accumulated in canyons, deep-water channels, and submarine fans during glacial periods of low sea level, while mud was deposited throughout the slope, in the relatively short reach of leveed-confined channels, and in the mud-rich fringes around the sandy fans. During interglacial periods of high sea level, the basin was blanketed by mud-rich deposits up to 10 m thick interbedded with distinctive carbonate-rich sediments. Deposition rates in the basin ranged from 0.07 m/ka to 0.59 m/ka over the last 450 ka. Mud deposition rates remained relatively constant at ∼0.16 m/ka during all time periods, while sand deposition only happened during glacial periods of low sea level with an average rate of 0.24 m/ka.
In addition to sea-level controls on sediment delivery, avulsions of the Golo River and its deltaic lobes preferentially routed sediment down either the North or South Golo canyons. Thus, while the larger, sequence-scale architecture of the basin is controlled by allogenic sea level forcing, millennial-scale autogenic processes operating on the shelf and in deep water shaped the distribution of sand and mud, and the internal geometry of the deltas and submarine fans that they fed. While some aspects of the Golo system are characteristic of steep, tectonically active margins, others such as the nature of connections between rivers and shelf-penetrating submarine canyons are observed in most margins with active submarine fans regardless of their tectonic setting.
Separating multiple episodes of partial melting in polyorogenic crust: An example from the Haiyangsuo complex, northern Sulu belt, eastern China
Authors: Feng Peng , Wang Lu , Brown Michael , Wang Songjie , Li Xiawen 
Published: October 2019

AbstractThe exotic Haiyangsuo complex is structurally part of the Sulu belt but its contact relationship with surrounding Sulu gneisses is unexposed and therefore unknown, making its affinity uncertain. It comprises gneisses with in-source leucosomes that host minor metabasite bodies; both are cut by leucogranite dikes. In this study, we determine the timing and petrogenesis of leucosomes and leucogranites and assess the tectonic affinity of the complex based on data from gneisses and metabasites. Most zircon from gneisses and leucosomes has oscillatory-zoned cores with CL-bright overgrowth rims, but some has CL-dark cores or mantles between cores and rims. CL-dark and bright zircon yield weighted mean ages of ca. 1817–1812 Ma. CL-dark zircon has flat heavy rare earth element (HREE) patterns and crystallization temperatures of 829–875 °C, suggesting metamorphic growth, whereas rims have steep HREE patterns but a similar range of crystallization temperatures, suggesting growth from anatectic melt; εHf (t = 1813 Ma) of –18.3 to –10.8 indicates a North China Craton source. Magmatic zircon from metabasites yields ages of ca. 825 Ma, similar to those of scattered metabasite occurrences in the North China Craton. Paleoproterozoic zircon cores were scavenged during magma ascent. By contrast, zircon cores from the leucogranites yield concordant dates of 776–701 Ma, consistent with protolith ages in the Sulu belt, whereas overgrowth mantles and rims yield weighted mean ages of ca. 220 Ma and 162 Ma, respectively. Both mantles and rims host multiphase solid inclusions, representing former melt, suggesting anatexis and crystallization of zircon first during initial decompression and then during orogenic collapse of the Sulu belt; whole-rock Nd and Sr isotope compositions implicate the Sulu belt gneisses as the source of these melts. Our interpretation of these data is that the Haiyangsuo complex has an early geologic history similar to the Jiaobei terrane from the southeastern part of the North China Craton and was incorporated into the Sulu belt during Triassic collision of the Yangtze and North China Cratons. The two stages of melting relate to Upper Triassic early exhumation and Upper Jurassic late-stage orogenic collapse, during which the leucogranite magma was derived from a source similar to one elsewhere in the Sulu belt such as the subducted Yangtze Craton and not the North China Craton. This shows that during continental collisions, crust from the upper plate may be dragged into the subduction channel, deformed, and subsequently exhumed in association with partial melting of the crust.
Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial
Authors: Aker Karoline , Støen Ragnhild , Eikenes Live , Martinez-Biarge Miriam , Nakken Ingeborg , Håberg Asta Kristine , Gibikote Sridhar , Thomas Niranjan 
Published: October 2019

ObjectiveTo evaluate the neuroprotective effect of therapeutic hypothermia (TH) induced by phase changing material (PCM) on MRI biomarkers in infants with hypoxic-ischaemic encephalopathy (HIE) in a low-resource setting.DesignOpen-label randomised controlled trial.SettingOne neonatal intensive care unit in a tertiary care centre in India.Patients50 term/near-term infants admitted within 5 hours after birth with predefined physiological criteria and signs of moderate/severe HIE.InterventionsStandard care (n=25) or standard care plus 72 hours of hypothermia (33.5°C±0.5°C, n=25) induced by PCM.Main outcome measuresPrimary outcome was fractional anisotropy (FA) in the posterior limb of the internal capsule (PLIC) on neonatal diffusion tensor imaging analysed according to intention to treat.ResultsPrimary outcome was available for 22 infants (44%, 11 in each group). Diffusion tensor imaging showed significantly higher FA in the cooled than the non-cooled infants in left PLIC and several white matter tracts. After adjusting for sex, birth weight and gestational age, the mean difference in PLIC FA between groups was 0.026 (95% CI 0.004 to 0.048, p=0.023). Conventional MRI was available for 46 infants and demonstrated significantly less moderate/severe abnormalities in the cooled (n=2, 9%) than in the non-cooled (n=10, 43%) infants. There was no difference in adverse events between groups.ConclusionsThis study confirmed that TH induced by PCM reduced brain injury detected on MRI in infants with moderate HIE in a neonatal intensive care unit in India. Future research should focus on optimal supportive treatment during hypothermia rather than looking at efficacy of TH in low-resource settings.Trial registration numberCTRI/2013/05/003693.
Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage
Authors: Wu Zhichao , Vianna Jayme R , Reis Alexandre S C , Zemborain Zane Z , Lee Seung H , Thenappan Abinaya , Weng Denis S D , Tsamis Emmanouil , Joiner Devon B , Ritch Robert , De Moraes Carlos Gustavo V , Hood Donald C 
Published: October 2019

PurposeTo understand the added value of Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements to conventional circumpapillary retinal nerve fibre layer (cpRNFL) thickness measurements on optical coherence tomography (OCT) imaging for discriminating between perimetric glaucoma and healthy eyes, evaluated through a qualitative evaluation.Methods384 healthy eyes and 188 glaucoma eyes were evaluated, and glaucoma eyes were categorised as perimetric (n=107) based on a history of ≥3 consecutive abnormal 24–2 visual field tests or suspected glaucoma if they did not (n=81). OCT-derived BMO-MRW and cpRNFL reports were qualitatively evaluated by two experienced graders in isolation at first, and then by using both reports combined. The diagnostic performance (sensitivity at 95% specificity, total and partial area under the receiver operating characteristic curve) of detecting perimetric glaucoma with each method were compared.ResultsAll diagnostic performance measures for detecting perimetric glaucoma eyes were not significantly different when using either the cpRNFL or BMO-MRW reports alone compared with using both reports combined (p≥0.190), nor when comparing the use of each report in isolation (p≥0.500).ConclusionsExperienced graders exhibited no difference in discriminating between perimetric glaucoma and healthy eyes when using a cpRNFL report alone, the BMO-MRW report alone or the two reports combined. Therefore, either OCT imaging report of the neuroretinal tissue could be used effectively for detecting perimetric glaucoma, but further studies are needed to determine whether there are specific advantages of each method, or the combination of both, when evaluating eyes that have a greater degree of diagnostic uncertainty.
Quantitative assessment of the effect of fasting on macular microcirculation: an optical coherence tomography angiography study
Authors: Karaküçük Yalçın , Beyoglu Abdullah , Çömez Ayşegül 
Published: October 2019

AimTo analyse the effect of fasting on the retinal vascular plexus and choriocapillaris structures in healthy subjects via Optical Coherence Tomography Angiography (OCTA).MethodsIn this prospective study, OCTA scans of 98 eyes in 49 healthy subjects were compared in fasting and non-fasting period. All cases had a full ophthalmological examination, with OCTA parameters measured, including superficial flow area (SCP) (mm2), deep flow area (DCP) (mm2), choriocapillaris flow area (CC) (mm2), superficial and deep vascular density (SVD and DVD, respectively) (%), superficial foveal avascular zone area (FAZs) (mm2), deep foveal avascular zone area (FAZd) (mm2), subfoveal choroidal thickness (SFCT) (µm) and central macular thickness (CMT) (µm).ResultsThe mean SCP, DCP and CC flow area values were induced to be significantly lower in a fasting than a non-fasting period (p<0.001, p<0.001, p=0.049, respectively). The mean VD in a fasting period was statistically significantly lower than in a non-fasting period at the SCP level (p=0.009). No statistically significant difference was found between the two periods in respect to DVD, FAZd and CMT (p=0.068, p=0.653 and p=0.531, respectively); however, FAZs were significantly lower in a non-fasting than fasting period (p=0.038). The SFCT was determined to be statistically significant and thicker during a fasting period (p<0.001).ConclusionThe current study documented several physiological changes in a fasting period, such as changes in SCP, DCP, CC flow, SVD and DVD, via OCTA.
Prevalence and factors associated with hypertension among adults in rural Sylhet district of Bangladesh: a cross-sectional study
Authors: Khanam Rasheda , Ahmed Salahuddin , Rahman Sayedur , Kibria Gulam Muhammed Al , Syed Jafar Raza Rizvi , Khan Ahad Mahmud , Moin Syed Mamun Ibne , Ram Malathi , Gibson Dustin G , Pariyo George , Baqui Abdullah H. 
Published: October 2019

ObjectivesLow-income and middle-income countries are undergoing epidemiological transition, however, progression is varied. Bangladesh is simultaneously experiencing continuing burden of communicable diseases and emerging burden of non-communicable diseases (NCDs). For effective use of limited resources, an increased understanding of the shifting burden and better characterisation of risk factors of NCDs, including hypertension is needed. This study provides data on prevalence and factors associated with hypertension among males and females 35 years and older in rural Bangladesh.MethodsThis is a population-based cross-sectional study conducted in Zakiganj and Kanaighat subdistricts of Sylhet district of Bangladesh. Blood pressure was measured and data on risk factors were collected using STEPS instrument from 864 males and 946 females aged 35 years and older between August 2017 and January 2018. Individuals with systolic blood pressure of ≥140 mm Hg or diastolic blood pressure of ≥90 mm Hg or taking antihypertensive drugs were considered hypertensive. Bivariate and multivariate analyses were performed to identify factors associated with hypertension.ResultsThe prevalence of hypertension was 18.8% (95% CI 16.3 to 21.5) and 18.7% (95% CI 16.3 to 21.3) in adult males and females, respectively. Among those who were hypertensive, the prevalence of controlled, uncontrolled and unaware/newly identified hypertension was 23.5%, 25.9% and 50.6%, respectively among males and 38.4%, 22.6% and 39.0%, respectively among females. Another 22.7% males and 17.8% females had prehypertension. Increasing age and higher waist circumference (≥90 cm for males and ≥80 cm for females) were positively associated with hypertension both in males (OR 4.0, 95% CI 2.5 to 6.4) and females (OR 2.8, 95% CI 2.0 to 4.1).ConclusionsIn view of the high burden of hypertension and prehypertension, a context-specific scalable public health programme including behaviour change communications, particularly to increase physical activity and consumption of healthy diet, as well as identification and management of hypertension needs to be developed and implemented.
Continuity of care and delivery of diabetes and hypertensive care among regular users of primary care services in Chile: a cross-sectional study
Authors: Leniz Javiera , Gulliford Martin C 
Published: October 2019

ObjectivesExplore factors related to continuity of care and its association with diabetes and hypertensive care, and disease control.DesignCross-sectional study.SettingData from the Chilean Health National Survey 2009–2010.ParticipantsRegular users of primary care services aged 15 or older.Primary and secondary outcome measuresProportion of hypertensive and diabetic patients with a blood pressure <140/90 mm Hg and HbA1c<7.0% respectively, self-report of diagnosis, treatment and recent foot and ophthalmological exams. Associations between continuity of care, sociodemographic characteristics, and primary and secondary outcomes were explored using logistic regression.Results3887 primary care service users were included. 14.7% recognised a usual GP, 82.3% of them knew their name. Continuity of care was positively associated with age >65 years (OR 4.81, 95% CI 3.16 to 7.32), being female (OR 1.66, 95% CI 1.34 to 2.05), retired (OR 2.22, 95% CI 1.75 to 2.83), obese (OR 1.66, 95% CI 1.29 to 2.14), high cardiovascular risk (OR 2.98, 95% CI 2.13 to 4.17) and widowed (OR 1.50, 95% CI 1.13 to 1.99), and negatively associated with educational level (8–12 vs <8 years OR 0.79, 95% CI 0.64 to 0.97), smoking (OR 0.65, 95% CI 0.52 to 0.82) and physical activity (OR 0.76, 95% CI 0.61 to 0.95). Continuity of care was associated with diagnosis awareness (OR 2.83, 95% CI 1.21 to 6.63), pharmacological treatment (OR 2.04, 95% CI 1.15 to 3.63) and a recent foot (OR 3.17, 95% CI 1.84 to 5.45) and ophthalmological exam (OR 3.20, 95% CI 1.66 to 6.18) in diabetic but not in hypertensive patients.ConclusionsContinuity of care was associated with higher odds of having a recent foot and ophthalmological exam in patients with diabetes, but not with better diseases control. Findings suggest patients with chronic conditions have better continuity of care access.
Public understanding and use of antibiotics in England: findings from a household survey in 2017
Authors: McNulty Cliodna A M , Collin Simon M , Cooper Emily , Lecky Donna M , Butler Chris C 
Published: October 2019

ObjectivesTo describe public understanding and use of antibiotics.DesignIpsos MORI Capibus survey of randomly-selected households.SettingEngland, January–April 2017.Participants2283 adults (≥15 years) including 777 parents of children <5 years old.Data collection and analysisThe main survey was undertaken in January 2017 (n=1691); data from an additional sample of parents were collected in April 2017 (n=592). Analyses were weighted to obtain estimates representative of the population.Main outcome measuresResponses to questions about antibiotics (awareness and perceptions), recent illness (expectations and experience), delayed and leftover antibiotics, and child illness stratified by demographic and socioeconomic characteristics.ResultsMost respondents (83% (1404/1691)) recognised that antibiotics kill bacteria/treat bacterial infections, but a sizeable minority (35% (592/1691)) thought that antibiotics kill viruses/treat viral infections. Overall levels of understanding have not changed substantially since similar surveys in 2003 and 2008/2009. One sixth of respondents who were prescribed antibiotics reported having leftovers (14% (64/498)) and 33% (22/64) kept these for possible future use. 1.3% of all respondents (23/1691) reported taking left-over antibiotics in the past year and 1.6% (26/1691) reported taking antibiotics obtained without a prescription. Higher social grade and educational qualifications were strongly positively associated with antibiotic knowledge; youngest (15–24 years), oldest (65 +years) and black, Asian and minority ethnic adults were less knowledgeable. Among 1319 respondents who had an infection or antibiotics within the past year, 43% (568/1319) said that they had not received any advice or information about antibiotics.ConclusionsDespite many campaigns, public understanding of antibiotics in England continues to combine correct basic knowledge held by most people with less prevalent but persistent and potentially harmful misunderstandings. These could be addressed through active provision of advice and information during primary and secondary care consultations and more effective public health interventions.