bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental pathways of pulmonary abnormalities in rheumatoid arthritis according to sequential HRCT findings
Authors: Tanaka Ayae , Kurasawa Kazuhiro , Soda Sayo , Takamura Yuta , Miyao Tomoyuki , Hasegawa Anna , Hiyama Tomoka , Yamazaki Ryutaro , Arai Satoko , Owada Takayoshi , Arima Masafumi , Maezawa Reika 
Published: January 2020

Abstract
BackgroundTo determine the patterns and development pathways of pulmonary abnormalities in patients with rheumatoid arthritis (RA).MethodsWe conducted a retrospective cohort study of consecutive RA patients who underwent high-resolution CT (HRCT) before and during biologic therapy. The presence of and change in 20 pulmonary lesions were recorded. Patterns of pre-existing and new lesions were examined by cluster analysis and tested for a correlation between pre-existing and new lesions.ResultsThe subjects were 208 patients (mean age, 59.2 years; mean disease duration, 7.9 years). The mean duration between HRCT examinations was 3.3 years. Pulmonary abnormalities were found in 70% of the patients: interstitial lung disease (ILD) in 39%, nodular lesions in 22%, and airway disease (AD) in 55%. There were commonly several different lesions in the same patient, and coexistence patterns were detected. In patients with abnormalities, AD was a shared abnormality. The incidence of pulmonary abnormalities was 10.5/100 person-years. Bronchiolitis was identified as the initial lesion. In patients with pre-existing abnormalities, a variety of new abnormalities developed in several patterns; e.g., ILD and progression of AD occurred in patients with AD. Strong correlation was found between new ground-glass opacity and each of pre-existing AD and honeycombing.ConclusionsPulmonary abnormalities exist and develop in patterns rather than at random. Based on the present findings, we propose the following development pathway for pulmonary abnormalities in RA: the initial lesion is bronchiolitis, which leads to the formation of complex AD, from which a variety of pulmonary lesions arise, particularly ILDs.
Effect of sedatives on in-hospital and long-term mortality of critically ill patients requiring extended mechanical ventilation for more than 48 hours
Authors: Lee Hannah , Choi Seongmi , Jang Eun Jin , Lee Juhee , Kim Dalho , Yoo Seokha , Oh Seung Young , Lee Ji-Eun , Ryu Ho Geol 
Published: January 2020

Abstract
Background The purpose of this study was to assess the correlation between sedatives and mortality in critically ill patients who required mechanical ventilation (MV) for ≥48 hours from 2007 to 2016.Methods We conducted a nationwide retrospective cohort study using population-based healthcare reimbursement claims database. : Data from adult patients (aged ≥18) who underwent MV for ≥48 hours between 2008 and 2016 were identified and extracted from the National Health Insurance Service database. The benzodiazepine group consisted of patients who were administered benzodiazepines for sedation during MV. All other patients were assigned to the non-benzodiazepine group.Results A total of 158,712 patients requiring MV for ≥48 hours were admitted in 55 centers in Korea from 2007 to 2016. The benzodiazepine group had significantly higher in-hospital and one-year mortality compared to the non-benzodiazepine group (37.0% vs. 34.3%, 55.0% vs. 54.4%, respectively). Benzodiazepine use decreased from 2008 to 2016, after adjusting for age, sex, and mean Elixhauser comorbidity index in the Poisson regression analysis (incidence rate ratio, 0.968; 95% CI 0.954–0.983; p < 0.001) whereas dexmedetomidine sales have continuously increased since the second half of 2010. Benzodiazepine use, older age, lower case volume (≤500 cases/year), chronic kidney disease, and higher Elixhauser comorbidity index were common significant risk factors for in-hospital and one-year mortality.Conclusion In critically ill patients undergoing MV for >48 hours, the use of benzodiazepines for sedation was associated with an increased risk of in-hospital mortality and one-year mortality.
Speckle tracking echocardiography before and after Surgical pulmonary valve replacement in Tetralogy of Fallot patients: Can STE elucidate early left ventricular dysfunction?
Authors: Ajami Gholam Hossein , Alwasabi Fathi , Mehdizadegan Nima , Edraki Mohammad Reza , Mohammadi Hamid , Amirghofran Ahmad ali , Ghasemzade Bahram , Keshavarz Kambiz , Amoozgar Hamid , Arabi Hamid , Naghshzan Amir , Borzouee Mohammad , Peiravian Farah 
Published: January 2020

Abstract
Objectives: TOF is the most common cyanotic CHD. We investigated left ventricular (LV) function after surgical pulmonary valve replacement (sPVR) in patients with repaired Tetralogy of Fallot (rTOF) by Speckle Tracking Echocardiography (STE).Methods: 58 volunteers participated in this study who divided into 3 groups including 22 PVR patients (mean age 18.96±7 year), 16 repaired Tetralogy of Fallot and 20 healthy age match control. For all patients, we performed 2D echocardiography and STE.Results: 2D echocardiography in all groups showed normal LV ejection fraction without a significant statistical difference (64% sPVR, 60% in repaired Tetralogy of Fallot and 62.5% in the control group). However, the mean global longitudinal strains (GLS) of LV were significantly reduced in both sPVR (-17.5±2.5%) and repaired Tetralogy of Fallot (-17.1±4.7%) patients rather than control group (-20.2±0.7%) (P = 0.003). But GLS had no statistically significant difference between repaired Tetralogy of Fallot and sPVR patients (P=0.9). Segmental analysis of longitudinal strain (LS) showed a significant decrease in sPVR patients and repaired Tetralogy of Fallot group in basal anterior, basal septal, basal anterolateral segments, mid-anterior and anterolateral segments. Except for lower LS in the apical-anteroseptal segment, this level was mostly spared in both sPVR and repaired Tetralogy of Fallot patients.Conclusion: LVEF was within normal range after sPVR patients, but the pattern of impaired segmental LS and GLS did not change as compared with rTOF. Surgical PVR in patients with repaired TOF may not have a significant effect on the improvement of LV function assessed by STE. LV damage which happens during surgical correction of TOF may have a permanent deteriorating effect on LV function.
Timing and Outcome of Surgical Treatment in Supracondylar Humeral Fractures in Pediatric Patients, Khartoum, Sudan
Authors: Tahir Khalid Abdelsalam , Ibrahim Ashrf E J. , Elbahri Hassan Mohamed Hassan 
Published: January 2020

Abstract
A study aims to evaluate the timing of close surgical treatment in supracondylar humeral fractures in pediatric patients and to know the radiological outcome of its management, through measuring the mean delay per hour and assessing post-surgical radiological outcome for reduction. A cross- sectional hospitals based study carried out in Khartoum state, through randomized cluster sampling, both data sheets and pre/post-surgical images were filled and collected. A well-constructed criteria were developed to assess the radiological outcome. With sample size of 41 cases, we found that the mean delay from trauma to surgery was 99 hours [SE, 13], equivalent to 4.13 days. The reduction outcome criterion was significant when comparing it with the surgeon level P value of 0.015, but when comparing it with the delay more than 32 hours and Gartland classification both weren’t significant with P values of 0.383 and 0.501 respectively. These results are refuting the current concepts about the impossible reduction after a delay more than 32 hours and filled the current gap of knowledge about the outcome of supracondylar humeral fractures Gartland III with delayed presentation.
To assess the quality of life in patients with chronic kidney disease undergoing hemodialysis at a satellite clinic, comparing patients from a median low-income household with patients from median middle- and upper-income households: cross-sectional study
Authors: JUNIOR UBIRACE FERNANDO ELIHIMAS , Forte Marília Costa Aranha , Pinto Alexandre Holanda Cavalcanti , França Eduardo Eriko Tenório de , Couto Jamila Pinho , Carvalho Antônio Augusto Lima , Filho Gutemberg Alves , Cabral Diogo Buarque Codeiro , Feitosa Saulo José da Costa , Aguiar Filipe Carrilho , Pereira Wallace , Cavalcanti Frederico Castelo Branco , Schwingel Paulo Adriano 
Published: January 2020

Abstract
Background: Chronic kidney disease is a financial challenge for global public health due to rising costs, a poorer quality of life. Globally, there has been an increase in the number of diabetic, hypertensive and obese patients, with a tendency to rise as life expectancy increases. Objective: To assess the quality of life of patients with chronic kidney disease on hemodialysis at a satellite clinic in Recife, Northeast Brazil, and comparing low-income patients funded by the national healthcare system with middle- and higher-income patients funded by private health insurance. Methods: The Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36) was applied, together with a complementary interview with socio-demographic data for all patients at a conventional hemodialysis clinic. All patients were submitted to the same hemodialysis protocol, 4 hours and 10 minutes, high flow biocompatible membranes with high mass transfer coefficient and an adequacy of Kt/V ≥1.2. Results: The poorest quality of life scores with the SF-36 were related to physical functioning and pain. The best scores were attributed to mental health, social functioning, general health and vitality with no differences between the household incomes. There was a positive association between education, role-emotional and physical functioning. Longer hemodialysis treatment times demonstrated a positive association with aspects of general health. Patients who had undergone hemodialysis between one and five years presented better quality of life scores with the SF-36. Conclusions: Hemodialysis treatment negatively influences the quality of life of patients with chronic kidney disease. Education seems to help patients to better understand and accept treatment, by raising the scores of the physical functioning and role-physical. The first year of hemodialysis seems to exert a more negative influence on the quality of life. Among all patients, pain and physical aspects seem to be the critical points, regardless of social class or income.
Preoperative Diagnosis of Hepatic Sinus Obstruction Syndrome Caused by Tusanqi and Evaluation of Therapeutic Effects after TIPS by Imaging and Pathology
Authors: YuSheng HE , kaicai Liu , weifu lv , chunze Zhou , Delei Cheng , Yijiang Zhu , Dong Lu , zhengfeng Zhang , Jingkun Xiao , Xingming Zhang 
Published: January 2020

Abstract
BACKGROUND:Transjugular intrahepatic portosystemic shunt(TIPS) is a method for the treatment of hepatic sinus obstruction syndrome (HSOS). This study investigated the preoperative diagnosis and prognosis of hsos caused by Tushanqi from the perspective of imaging and pathology. MATERIAL AND METHOD: TIPS was administered to our hospital for 19 patients with HSOS who had a history of taking Tusanqi soaking liquor or Chinese medicine between September 2014 to December 2018. They underwent enhanced abdominal CT or MR scans on the day before surgery and one month after surgery. ultrasound-guided liver biopsy, and specimens for HE staining.RESULTS:Preoperative imaging showed increased liver volume, uneven density, moderate to severe effusion in the abdominal cavity, thickening and distortion of the hepatic artery, uneven perfusion of the liver parenchyma, slender or unclear three hepatic veins, and slender inferior vena cava or flat, but still unobstructed. Pathological examination showed extensive edema and degeneration of hepatocytes. hepatic sinus was obviously congested, dilated, fibrous connective tissue proliferated, and expanded venules in the interfiber space.One month after operation: the liver volume was smaller than before, no obvious abnormalities were found in the liver parenchyma, and the peritoneal effusion was significantly less or even disappeared.Postoperative pathology showed marked improvement of hepatocellular edema, slight dilatation and congestion of hepatic sinus.CONCLUSIONS: Imaging and pathology can help the diagnosis of HSOS by Tusanqi , but also evaluate the therapeutic effect of TIPS on the disease.
ANÁLISE DE UMA SEQUÊNCIA DIDÁTICA SOBRE FERMENTAÇÃO: INTERAÇÕES DISCURSIVAS E A ELABORAÇÃO DO CONHECIMENTO
Authors: Lorencini Júnior Álvaro , Rossi Sbardellati Christiane 
Published: January 2020

Este estudo teve como objetivo analisar as interações discursivas entre a professora e seus alunos em uma sequência didática sobre fermentação. A análise enfoca o processo mental construído pelo aluno durante a elaboração do conhecimento. Nessa pesquisa foram analisados episódios de uma sequência didática com alunos do 7º ano do Ensino Fundamental de uma escola particular do município de Maringá – Paraná. Os dados foram coletados durante as aulas no laboratório da escola, mediante gravações em áudio com um grupo de 10 alunos. Para a análise dos conteúdos de aprendizagem da sequência didática aplicada e das interações discursivas construídas, utilizou-se a estrutura analítica proposta por Zabala (1998) e as categorias idealizadas por Mortimer e Scott (2002) respectivamente, visto que nos dão suporte no sentido de compreender a importância do ambiente, do diálogo e das interações entre os indivíduos. Os resultados obtidos evidenciam os padrões discursivos durante as intervenções da professora, bem como foi possível identificar elementos potenciais e limitantes que favorecem ou impedem a elaboração do conhecimento por parte dos alunos, no sentido da re(estruturação) de suas ideias e na construção de novos significados.

Palavras-chave: Ensino de Ciências; Interações Discursivas; Sequência Didática
ORGANIZAÇÃO DO ENSINO DE ARTE COM BASE EM PRESSUPOSTOS DA TEORIA HISTÓRICO – CULTURAL
Authors: Oliveira Valdiléia Xavier de , Sforni Marta Sueli de Faria 
Published: January 2020

A presente pesquisa, de natureza qualitativa, teve como objetivo de investigar como o ensino de Arte pode ser organizado para que promova o desenvolvimento dos estudantes. Para a sua efetivação, foram realizadas análises documentais, estudos bibliográficos e um experimento didático. Os estudos bibliográficos foram fundamentados em autores da Teoria Histórico-Cultural e obras de outros autores que trabalham com o tema desta pesquisa com base no mesmo referencial teórico e que proporcionaram a compreensão sobre a relação entre a Arte o desenvolvimento das funções psicológicas superiores. O experimento didático foi desenvolvido com estudantes do 3º ano do Ensino Fundamental de uma escola pública de um município da região noroeste do Estado do Paraná. A análise das atividades organizadas e desenvolvidas por meio do experimento didático possibilitou a identificação das funções psíquicas superiores mobilizadas durante as atividades de ensino, bem como as ações docentes que foram determinantes para a promoção da aprendizagem s e, consequentemente, para o desenvolvimento psíquico dos estudantes.
Modyfikacje systemu wspomagającego pozycjonowanie pacjenta w czasie procedury napromieniania całego ciała
Authors: Zając Arkadiusz , Masternak Anna , Dąbrowski Stefan , Boruta Jan , Kraszewski Piotr , Gniadek Rafał 
Published: January 2020

W publikacji przedstawiono wprowadzone modyfikacje do stworzonego w Narodowym Centrum Badań Jądrowych systemu wspomagającego poprawne
i powtarzalne ułożenie pacjenta podczas stosowania procedury napromieniania całego ciała
Complement or competition in water governance? Analysing two collaborative water management arrangements in one river basin
Authors: Mancheva Irina 
Published: January 2020

Abstract
This study aims at advancing collaborative governance theory by investigating the interaction between two different collaborative arrangements within the same forested area of high ecological and social value in the Vindel River basin. Semi-structured interviews, policy documents and observations of board meetings were analysed based on analytical typologies of collaborative arrangements to answer the following questions: which factors can explain why a new collaborative arrangement was established within an area where one already existed? In what way do the two arrangements compete with or complement each other? And, to what extent do they address the effects of forestry on water? The analysis shows that a new collaborative arrangement was formed because the existing arrangement did not materialise certain stakeholders' expectations. Moreover, the two collaborative arrangements do not compete but rather complement each other. The newly established organisational/action collaborative arrangement presented those stakeholders most interested in on-the-ground action with the appropriate venue while freeing them from the organisational/policy arrangement that did not match their aims. However, both arrangements experienced power misbalances as certain stakeholders were perceived as having more influence on their agenda. Collaboration at this local-regional level was found to focus on limited problems with concrete and feasible solutions, such as fish migration, rather than on the complex problems with solutions marked by ecological uncertainty and power asymmetries, e.g. diffuse pollution from forestry.
Enzyme activity of waste activated sludge extracts
Authors: Liu Ziyi , Smith Stephen R. 
Published: January 2020

AbstractWastewater treatment and generated biological sludge provide an alternative source of enzymes to conventional industrial production methods. Here, we present a protocol for extracting enzymes from activated sludge using ultrasonication and surfactant treatment. Under optimum conditions, ultrasound disruption of activated sludge gave recovery rates of protease and cellulase enzymes equivalent to 63.1% and ∼100%, respectively. The extracting of enzymes from activated sludge represents a potentially significant, high-value, resource recovery option for biological sludge generated by municipal wastewater treatment.
Bioactive Constituents from South American Prosopis and their Use and Toxicity
Authors: Schmeda-Hirschmann Guillermo , Theoduloz Cristina , Jiménez-Aspee Felipe , Echeverría Javier 
Published: January 2020

Background:The pods from several South American Prosopis species have been considered relevant food in arid and semi-arid South America since prehistoric times. Traditionally the meal from the pods was processed to prepare different foods and beverages.Objective:The objective was to discuss literature from the archaeological evidence of use to study the chemistry and (bio)activity of the extracts and secondary metabolites occurring in different Prosopis food products.Method:The review was carried out by searching electronic databases, including ScienceDirect, SciFinder, Scopus, Scielo, Google Scholar, PubMed and hand-search on literature. The review mainly covers studies performed in the year 1995-2019 and the first-hand experience of the authors. References on the historical and prehistorical uses of the natural resource were also included.Results:In the last decades, most studies on the edible South American Prosopis focused on the constituents of pods meal, traditional preparations and by-products. Total 45 flavonoids, ellagic acid derivatives, catechin and simple phenolics were identified. Alkaloids occur mainly in the leaves, that are not used for human nutrition but as food for domestic animals. Piperidine alkaloids, tryptamine, tyramine and β-phenethylamine were isolated and identified from several species. The (bio)activity studies included mainly the antioxidant effect, antiinflammatory and enzyme inhibition associated with metabolic syndrome. The products showed no toxicity or mutagenic effect.Conclusions:While data on the chemistry, some (bio)activities and toxicity are available for the pods meal and byproducts, little is known about the composition of the fermented Algarrobo beverages. Further studies are needed on the digestion of Algarrobo products both in humans and cattle.
Evaluation of Strategies for Decreasing Blood Glucose Using Albuminbinding Domain
Authors: Fan Lin , Fan Yani , Fan Hongwei , Huang Kaizong 
Published: January 2020

Objective:Frequent administrations for DPPIV-resistant GLP-1 analogs are necessary to maintain the blood concentrations due to the short half-life of less than 5 minutes. However, most delivery systems that possess the ability of sustainable release of GLP-1 have drawbacks such as low yield, high cost and undesirable side effects. Therefore, we aimed to prepare a simple and efficient delivery system that could be feasibly applied to reduce blood glucose.Methods:A novel GLP-1 delivery system (GLP-1-ELPs-SA) was prepared and characterized by circular dichroism. Furthermore, the activity and property of GLP-1-ELPs-SA were evaluated in vitro and in vivo.Results:GLP-1-ELPs-SA are easily expressed in E. coli in a soluble formulation and purified through the inverse transition cycle. GLP-1-ELPs-SA spontaneously generated depot under physiological conditions. GLP-1-ELPs-SA was also found to be dispersed in the blood vessels from the depot and showed a high affinity to bind with mice (C57BL/6J) albumin, which shows that GLP-1-ELPs-SA has a long circulation time in vivo.Conclusions:Our delivery system could markedly decrease the clearance of recombinant proteins based on serum albumin, without substantially increasing the protein molecular weight and remarkably reducing the blood glucose within 120 h.
Disintegrin Tablysin-15 Suppresses Cancer Hallmarks in Melanoma Cells by Blocking FAK/Akt/ERK and NF-κB Signaling
Authors: Deng Zhenhui , Zeng Qingye , Chai Jinwei , Zhang Bei , Zheng Wenhong , Xu Xueqing , Wu Jiguo 
Published: January 2020

Background:
Integrins are crucial anti-cancer therapy targets. We previously showed that
tablysin-15 is an integrin antagonist with its Arg-Gly-Asp motif in a novel structural context.

Objective:
Here we investigated the anti-cancer effects and mechanisms of action of tablysin-15 in
melanoma cells.

Methods:
Cell adhesion, competitive binding, cell viability, and ATP chemiluminescence assays
were used to analyze the binding of tablysin-15 to αvβ3 integrin and its phenotypic effects. Wound
healing, transwells, and zymography were performed to detect motility and matrix metalloproteinase-
2/-9 activities. PARP and caspase-3 cleavage were used as apoptosis assays, while LDH release
and flow cytometry were used for necrosis and cell cycle analysis. The expression of mRNAs and
proteins of target molecules was measured by qRT-PCR and western blotting, respectively.

Results:
Tablysin-15 dose-dependently inhibited the proliferation, migration, and invasion of M21
cells through integrin αvβ3. The proliferation inhibition caused by tablysin-15 was attributable to
G0/G1 phase arrest rather than apoptosis or necrosis. Furthermore, tablysin-15 suppressed MMP-2/-
9 activities and the mRNA expression of MMP-2/-9 and COX-2 but was upregulated TIMP-1 in
M21 cells. Meanwhile, tablysin-15 suppressed the expression of cyclin D1/E and CDK 2/6, the
phosphorylation of FAK, Akt, and ERK, and nuclear translocation of NF-κB, while increasing the
expression of the CDK inhibitor p21waf1/C1. Taken together, tablysin-15 might inhibit melanoma cell
metastasis and proliferation by competing with αvβ3 integrin, thereby blocking FAK-associated signaling
pathways and nuclear translocation of NF-κB.

Conclusions:
Tablysin-15 has reliable anti-cancer effects against M21 melanoma cells, suggesting
tablysin-15 is a promising anti-tumor drug.