bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness of a National Sugar-Sweetened Beverage Tax to Reduce Cancer Burdens and Disparities in the United States
Authors: Du Mengxi , Griecci Christina F , Kim David D , Cudhea Frederick , Ruan Mengyuan , Eom Heesun , Wong John B , Wilde Parke E , Michaud Dominique S , Lee Yujin , Micha Renata , Mozaffarian Dariush , Zhang Fang Fang 
Published: August 2020

Abstract

Background
Sugar-sweetened beverage (SSB) consumption contributes to obesity, a risk factor for 13 cancers. Although SSB taxes can reduce intake, the health and economic impact on reducing cancer burdens in the United States are unknown, especially among low-income Americans with higher SSB intake and obesity-related cancer burdens.

Methods
We used the Diet and Cancer Outcome Model, a probabilistic cohort state-transition model, to project health gains and economic benefits of a penny-per-ounce national SSB tax on reducing obesity-associated cancers among US adults aged 20 years and older by income.

Results
A national SSB tax was estimated to prevent 22 075 (95% uncertainty interval [UI] = 16 040-28 577) new cancer cases and 13 524 (95% UI = 9841-17 681) cancer deaths among US adults over a lifetime. The policy was estimated to cost $1.70 (95% UI = $1.50-$1.95) billion for government implementation and $1.70 (95% UI = $1.48-$1.96) billion for industry compliance, while saving $2.28 (95% UI = $1.67-$2.98) billion cancer-related healthcare costs. The SSB tax was highly cost-effective from both a government affordability perspective (incremental cost-effectiveness ratio [ICER] = $1486, 95% UI = -$3516-$9265 per quality-adjusted life year [QALY]) and a societal perspective (ICER = $13 220, 95% UI = $3453-$28 120 per QALY). Approximately 4800 more cancer cases and 3100 more cancer deaths would be prevented, and $0.34 billion more healthcare cost savings would be generated among low-income (federal poverty-to-income ratio [FPIR] ≤ 1.85) than higher-income individuals (FPIR &gt; 1.85).

Conclusions
A penny-per-ounce national SSB tax is cost-effective for cancer prevention in the United States, with the largest health gains and economic benefits among low-income Americans.
IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405
Authors: Guercio Brendan J , Zhang Sui , Ou Fang-Shu , Venook Alan P , Niedzwiecki Donna , Lenz Heinz-Josef , Innocenti Federico , Pollak Michael N , Nixon Andrew B , Mullen Brian C , O’Neil Bert H , Shaw James E , Polite Blase N , Benson Al Bowen , Atkins James N , Goldberg Richard M , Brown Justin C , O’Reilly Eileen M , Mayer Robert J , Blanke Charles D , Fuchs Charles S , Meyerhardt Jeffrey A 
Published: August 2020

AbstractBackgroundEnergy balance-related biomarkers are associated with risk and prognosis of various malignancies. Their relationship to survival in metastatic colorectal cancer (mCRC) requires further study.MethodsBaseline plasma insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3, IGFBP-7, C-peptide, and adiponectin were measured at time of trial registration in a prospective cohort of patients with mCRC participating in a National Cancer Institute–sponsored trial of first-line systemic therapy. We used Cox proportional hazards regression to adjust for confounders and examine associations of each biomarker with overall survival (OS) and progression-free survival (PFS). P values are 2-sided.ResultsMedian follow-up for 1086 patients was 6.2 years. Compared with patients in the lowest IGFBP-3 quintile, patients in the highest IGFBP-3 quintile experienced an adjusted hazard ratio (HR) for OS of 0.57 (95% confidence interval [CI] = 0.42 to 0.78; Pnonlinearity &lt; .001) and for PFS of 0.61 (95% CI = 0.45 to 0.82; Ptrend = .003). Compared with patients in the lowest IGFBP-7 quintile, patients in the highest IGFBP-7 quintile experienced an adjusted hazard ratio for OS of 1.60 (95% CI = 1.30 to 1.97; Ptrend &lt; .001) and for PFS of 1.38 (95% CI = 1.13 to 1.69; Ptrend &lt; .001). Plasma C-peptide and IGF-1 were not associated with patient outcomes. Adiponectin was not associated with OS; there was a nonlinear U-shaped association between adiponectin and PFS (Pnonlinearity = .03).ConclusionsAmong patients with mCRC, high plasma IGFBP-3 and low IGFBP-7 were associated with longer OS and PFS. Extreme levels of adiponectin were associated with shorter PFS. These findings suggest potential avenues for prognostic and therapeutic innovation.
Cardiovascular Toxicity of Targeted Therapies for Cancer: An Overview of Systematic Reviews
Authors: Van Leeuwen Marina T , Luu Steven , Gurney Howard , Brown Martin R , Pearson Sallie-Anne , Webber Kate , Hunt Lee , Hong Soojung , Delaney Geoffrey P , Vajdic Claire M 
Published: August 2020

AbstractBackgroundSeveral targeted therapies for cancer have been associated with cardiovascular toxicity. The evidence for this association has not been synthesized systematically nor has the quality of evidence been considered. We synthesized systematic review evidence of cardiovascular toxicity of individual targeted agents.MethodsWe searched MEDLINE, Embase, and the Cochrane Database of Systematic Reviews for systematic reviews with meta-analyses of cardiovascular outcomes for individual agents published to May 2020. We selected reviews according to prespecified eligibility criteria (International Prospective Register of Systematic Reviews CRD42017080014). We classified evidence of cardiovascular toxicity as sufficient, probable, possible, or indeterminate for specific cardiovascular outcomes based on statistical significance, study quality, and size.ResultsFrom 113 systematic reviews, we found at least probable systematic review evidence of cardiovascular toxicity for 18 agents, including high- and all-grade hypertension for bevacizumab, ramucirumab, axitinib, cediranib, pazopanib, sorafenib, sunitinib, vandetanib, aflibercept, abiraterone, and enzalutamide, and all-grade hypertension for nintedanib; high- and all-grade arterial thromboembolism (includes cardiac and/or cerebral events) for bevacizumab and abiraterone, high-grade arterial thromboembolism for trastuzumab, and all-grade arterial thromboembolism for sorafenib and tamoxifen; high- and all-grade venous thromboembolism (VTE) for lenalidomide and thalidomide, high-grade VTE for cetuximab and panitumumab, and all-grade VTE for bevacizumab; high- and all-grade left ventricular ejection fraction decline or congestive heart failure for bevacizumab and trastuzumab, and all-grade left ventricular ejection fraction decline/congestive heart failure for pazopanib and sunitinib; and all-grade corrected QT interval prolongation for vandetanib.ConclusionsOur review provides an accessible summary of the cardiovascular toxicity of targeted therapy to assist clinicians and patients when managing cardiovascular health.
BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
Authors: Morand Susan , Stanbery Laura , Walter Adam , Rocconi Rodney P , Nemunaitis John 
Published: August 2020

Abstract
BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation.
An Endovascular Surgery Experience in Far-Forward Military Healthcare—A Case Series
Authors: Coughlin Daniel J , Boulter Jason H , Miller Charles A , Curry Brian P , Glaser Jacob , Fernandez Nathanial , Bell Randy S , Schuette Albert J 
Published: August 2020

Abstract

Summary

Introduction
The advancement of interventional neuroradiology has drastically altered the treatment of stroke and trauma patients. These advancements in first-world hospitals, however, have rarely reached far forward military hospitals due to limitations in expertise and equipment. In an established role III military hospital though, these life-saving procedures can become an important tool in trauma care.

Materials and Methods
We report a retrospective series of far-forward endovascular cases performed by 2 deployed dual-trained neurosurgeons at the role III hospital in Kandahar, Afghanistan during 2013 and 2017 as part of Operations Resolute Support and Enduring Freedom.

Results
A total of 15 patients were identified with ages ranging from 5 to 42 years old. Cases included 13 diagnostic cerebral angiograms, 2 extremity angiograms and interventions, 1 aortogram and pelvic angiogram, 1 bilateral embolization of internal iliac arteries, 1 lingual artery embolization, 1 administration of intra-arterial thrombolytic, and 2 mechanical thrombectomies for acute ischemic stroke. There were no complications from the procedures. Both embolizations resulted in hemorrhage control, and 1 of 2 stroke interventions resulted in the improvement of the NIH stroke scale.

Conclusions
Interventional neuroradiology can fill an important role in military far forward care as these providers can treat both traumatic and atraumatic cerebral and extracranial vascular injuries. In addition, knowledge and skill with vascular access and general interventional radiology principles can be used to aid in other lifesaving interventions. As interventional equipment becomes more available and portable, this relatively young specialty can alter the treatment for servicemen and women who are injured downrange.
Do model emission line galaxies live in filaments at z ∼ 1?
Authors: Gonzalez-Perez V , Cui W , Contreras S , Baugh C M , Comparat J , Griffin A J , Helly J , Knebe A , Lacey C , Norberg P 
Published: August 2020

ABSTRACT
Current and future cosmological surveys are targeting star-forming galaxies at z ∼ 1 with nebular emission lines. We use a state-of-the-art semi-analytical model of galaxy formation and evolution to explore the large-scale environment of star-forming emission line galaxies (ELGs). Model ELGs are selected such that they can be compared directly with the DEEP2, VVDS, eBOSS-SGC, and DESI surveys. The large-scale environment of the ELGs is classified using velocity–shear–tensor and tidal–tensor algorithms. Half of the model ELGs live in filaments and about a third in sheets. Model ELGs that reside in knots have the largest satellite fractions. We find that the shape of the mean halo occupation distribution of model ELGs varies widely for different large-scale environments. To interpret our results, we also study fixed number density samples of ELGs and galaxies selected using simpler criteria, with single cuts in stellar mass, star formation rate, and [O ii] luminosity. The fixed number density ELG selection produces samples that are close to L[O ii] and SFR-selected samples for densities above 10−4.2 h3 Mpc−3. ELGs with an extra cut in stellar mass applied to fix their number density, present differences in sheets and knots with respect to the other samples. ELGs, SFR, and L[O ii] selected samples with equal number density have similar large-scale bias but their clustering below separations of 1h−1 Mpc is different.
Chirp mass and spin of binary black holes from first star remnants
Authors: Kinugawa Tomoya , Nakamura Takashi , Nakano Hiroyuki 
Published: August 2020

ABSTRACT
We performed Population III (Pop III) binary evolution using population synthesis simulations for seven different models. We found that Pop III binaries tend to be binary black holes (BBHs) with chirp mass Mchirp ∼ 30 M⊙ and they can merge in the present day, due to a long merger time. The merger rate densities of Pop III BBHs at z = 0 are in the range 3.34–21.2 $\rm yr^{-1}\,Gpc^{-3}$ which is consistent with the Advanced Laser Interferometer Gravitational Wave Observatory (aLIGO)/Advanced Virgo (aVIRGO) result of 9.7–101 $\rm yr^{-1}\,Gpc^{-3}$. These Pop III binaries might contribute some portion of the massive BBH gravitational wave (GW) sources detected by aLIGO/aVIRGO. We also calculated the redshift dependence of Pop III BBH mergers. We found that Pop III low-spin BBHs tend to merge at low redshift, while Pop III high-spin BBHs merge at high redshift, which can be confirmed by future GW detectors such as Einstein Telescope (ET), Cosmic Explorer (CE), and DECi-hertz Interferometer Gravitational wave Observatory (DECIGO). These detectors can also check the redshift dependence of the BBH merger rate and spin distribution. Our results show that, except for one model, the mean effective spin 〈χeff〉 at z = 0 lies in the range 0.02–0.3, while at z = 10 it is 0.16–0.64. Therefore, massive stellar-mass BBH detection by GWs will be key for stellar evolution study in the early Universe.
Modelling R Coronae Borealis stars: effects of He-burning shell temperature and metallicity
Authors: Crawford Courtney L , Clayton Geoffrey C , Munson Bradley , Chatzopoulos Emmanouil , Frank Juhan 
Published: August 2020

ABSTRACT
The R Coronae Borealis (RCB) stars are extremely hydrogen-deficient carbon stars that produce large amounts of dust, causing sudden deep declines in brightness. They are believed to be formed primarily through white dwarf mergers. In this paper, we use mesa to investigate how post-merger objects with a range of initial He-burning shell temperatures from 2.1 to 5.4 × 108 K with solar and subsolar metallicities evolve into RCB stars. The most successful model of these has subsolar metallicity and an initial temperature near 3 × 108 K. We find a strong dependence on initial He-burning shell temperature for surface abundances of elements involved in the CNO cycle, as well as differences in effective temperature and radius of RCBs. Elements involved in nucleosynthesis present around 1 dex diminished surface abundances in the 10 per cent solar metallicity models, with the exception of carbon and lithium that are discussed in detail. Models with subsolar metallicities also exhibit longer lifetimes than their solar counterparts. Additionally, we find that convective mixing of the burned material occurs only in the first few years of post-merger evolution, after which the surface abundances are constant during and after the RCB phase, providing evidence for why these stars show a strong enhancement of partial He-burning products.
3 In-Hospital Child Mortality after Consolidation of Two Pediatric Intensive Care Units
Authors: Parvez Sehar , Soper Juliet 
Published: August 2020

Abstract

Background
While high-volume specialized Pediatric Intensive Care Units (PICUs) increase the survival of critically ill children, the benefits of consolidating PICUs to a single site may be outweighed by the need to transport critically ill children when the area serviced has a low population density and vast geography.

Objectives
This study seeks to describe the impact of PICU consolidation on mortality of children from the southern part of a Canadian province, after presentation to nearest hospital, following consolidation of PICUs to a single more centrally located PICU.

Design/Methods
We conducted a retrospective chart review of children with a primary residence in the southern part of the province, who died between January 2008 and December 2017 after presentation to the nearest hospital. Children who died prior to presentation to hospital or did not have return of spontaneous circulation at any time after presentation were excluded from analysis. Child demographics, year of death, cause of death, and Pediatric Risk of Mortality III (PRISM III) score, and duration and type of treatments provided were abstracted from health records. Population census data was obtained from the 2016 Canada Census. Deaths were grouped for analysis according to the child’s place of residence within three specific administrative areas. Nonparametric Mann Whitney U-test was used for descriptive analysis.

Results
Eighty-six (86) children from the southern part of the province died following presentation to the nearest hospital during the 10-year study period. The observed population rate of in-hospital deaths was 6.8 per 100,000 children per year before consolidation and 8.5 per 100,000 children per year after consolidation of PICU services. Variation in the population rate of in-hospital deaths before and after consolidation of PICUs was observed between administrative areas (p=0.016). The data did not appear to show an association with urban or non-urban areas. Children who died after consolidation were more likely to receive pain relief (p=0.013), and palliative care consultation (p=0.005) than those who died prior to consolidation. No change in acuity at presentation to hospital or cause of death was observed following PICU consolidation (p=0.3).

Conclusion
This study did not find evidence of a change in the rate of in-hospital child deaths per 100,000 children following consolidation of PICU services in a Canadian province.
4 Saline-lock versus continuous infusion: maintaining peripheral intravenous catheter access in children
Authors: Yeung Frances , Taheri Sepideh , Miller Michael , Ojha Rahul , McKelvie Brianna , Bock Dirk , Poonai Naveen , Cameron Saoirse 
Published: August 2020

Abstract

Background
Peripheral intravenous catheter (PIVC) insertion is a painful and invasive procedure performed on most paediatric patients. In children, PIVCs are maintained by either a continuous infusion of fluid “to keep vein open” (TKVO) or a saline-lock (SL). There is little uniformity between pediatric centres as to which method is used, and evidence is required to decide which method, if any, best maintains PIVC access.

Objectives
The primary objective was to compare duration of functional PIVC patency between TKVO and SL in children. Secondary objectives included assessing PIVC-related complications and patient/caregiver satisfaction.

Design/Methods
This prospective, time-allocated trial enrolled eligible patients from newborn to 17 years of age admitted to our pediatric ward. Patients enrolled in the first 3 months were assigned to TKVO, and patients in the latter 3 months were assigned to SL. Time of PIVC insertion and removal, PIVC-related complications, and satisfaction surveys were collected. Independent t-tests and chi-square tests were used to compare differences between arms for continuous and categorical outcomes, respectively.

Results
Complete PIVC data was available on 172 (n=85 TKVO, n=87 SL) of 194 enrolled patients. The mean (SD) duration of PIVC patency was 41.68 (41.71) hours in the TKVO group, and 44.05 (41.46) hours in the SL group, which was not statistically significant (p=0.71). There were no significant differences in complication rates or overall patient/caregiver satisfaction between the two groups. One patient in the TKVO group had their PIVC removed due to risk of strangulation from tubing.

Conclusion
There were no significant differences between TKVO and SL in the duration of PIVC patency in our pediatric population. This is consistent with previous results in neonates. There were also no significant differences in complication rates and overall patient/caregiver satisfaction. Overall, SL is a safe and reasonable alternative to TKVO in maintaining PIVC patency in children.
6 Factors associated with treatment failure of high flow nasal cannula (HFNC) among children with bronchiolitis: a single centre retrospective study
Authors: D’Alessandro Michelle , Vanniyasingam Thuva , Patel Ashaka , Gupta Ronish , Giglia Lucy , Federici Giuliana , Wahi Gita 
Published: August 2020

Abstract

Background
Bronchiolitis is the most common viral lower respiratory tract infection in children under two years of age and is the leading cause of hospital admission for children under the age of one year. Respiratory support for bronchiolitis with high flow nasal cannula (HFNC) is increasingly being used outside of critical care areas and in community hospitals. It is important to understand the patient factors associated with HFNC treatment failure in order to identify which patients are at higher risk for requiring escalation of respiratory support and transfer to a pediatric critical care centre.

Objectives
The primary objective of this study was to evaluate the patient characteristics that are associated with HFNC treatment failure in bronchiolitis.

Design/Methods
We completed a retrospective review of patients under 24 months of age with a clinical diagnosis of bronchiolitis admitted to a single tertiary level children’s hospital for supportive management with HFNC between January 2014 and December 2018. Patients who were mechanically ventilated or on non-invasive positive pressure ventilation prior to the initiation of HFNC during their hospital stay were excluded. HFNC treatment failure was the primary endpoint of the study, with treatment failure defined as escalation to non-invasive positive pressure or invasive mechanical ventilation. Multivariable logistic regression analysis was used to identify the patient demographic, clinical, and biochemical parameters associated with HFNC failure.

Results
Four hundred and thirty-five patient charts were identified, of which 208 patients met inclusion criteria for the study. Of these patients, 61 (29%) were classified as HFNC treatment failures. The likelihood of failing HFNC support was reduced with older age (OR 0.89; 95% CI 0.81, 0.97; p= 0.011) and greater time spent on HFNC (OR 0.94; 95% CI 0.92, 0.96; p&lt;0.001). Patients with a Modified Tal score greater than 5 at 4 hours of HFNC treatment had a greater likelihood of failing HFNC support (OR 2.81; 95% CI 1.04, 7.64; p= 0.042).

Conclusion
This was the first study to examine predictors of HFNC failure among Canadian children with bronchiolitis. We found that patient age, time spent on HFNC, and severity of bronchiolitis as defined using a Modified Tal score were associated with HFNC failure. These patient factors should be considered when initiating HFNC for bronchiolitis, and may identify patients at risk for escalation of respiratory support, warranting earlier referral to pediatric critical care centres.