bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance use among patients in specialized mental health services in Norway: prevalence and patient characteristics based on a national census
Authors: Andersson Helle Wessel , Lilleeng Solfrid E. , Ruud Torleif , Ose Solveig Osborg 
Published: December 2019

Abstract
Background: Most studies on substance use among psychiatric patients focus on patients within specific diagnostic categories. Less is known about substance use among the general psychiatric patient population. The aim of this study was to investigate the clinical and demographic variation in the prevalence of substance use among psychiatric in-patients and outpatients in Norway.Methods: A national census in psychiatric institutions and outpatient clinics was conducted. Data were returned for 2,358 in-patients (response rate, 65%) and 23,167 outpatients (response rate, 60%). Substance use was measured based on substance use disorder diagnosis or reported substance use in the last four weeks (alcohol 2–4 days a week or illicit drug use). Regression analyses controlling for demographic and socio-demographic characteristics were carried out.Results: Substance use was identified in 32.4% of in-patients and 13.9% of outpatients. The most frequently reported substances used were alcohol, sedatives and cannabis. Among in-patients, the prevalence of substance use was highest in patients with schizophrenia, personality disorders and anxiety disorders. Among outpatients, the prevalence was highest in patients with schizophrenia and other psychoses. In-patients with anxiety disorders and outpatients with schizophrenia and other psychoses had a significantly higher risk of substance use than other patients. In both samples, the prevalence of substance use was higher among males, 24–29-year-olds and the most socially deprived.Conclusions: This study provides further knowledge about patients at risk for co-morbid substance abuse and poor treatment outcomes. Clinicians may consider targeting patients with severe mental illness, young males and those who are socially deprived in efforts to prevent emerging substance abuse and improve outcomes.
Anterior or posterior approach in the surgical treatment of cervical radiculopathy; neurosurgeons’ preference in the Netherlands.
Authors: Broekema Anne Elsina Henderika , Groen Rob JM , Tegzess Erzsi , Reneman Michiel F , Soer Remko , Kuijlen Jos MA 
Published: December 2019

Abstract
Background For cervical foraminal nerve root decompression, anterior cervical discectomy with fusion (ACDF) or posterior cervical foraminotomy (PCF) can be applied. Amongst neurosurgeons, there seems to be a tendency to prefer ACDF over PCF, even though there are some advantages in favor of PCF. The object of present study is to evaluate which factors determine the choice for an anterior or posterior surgical approach in patients with a cervical radicular syndrome based on foraminal pathology. Methods A web-based survey was sent to all 133 neurosurgeons in the Netherlands. The first part focused on general perceived (dis)advantages of ACDF and PCF. The second part concerned questions about the choice between the two procedures. Furthermore, it was analyzed if exposure during training, amount of performed surgeries, assumed reoperation and complication rates influenced the choice of procedure by conducting Chi-square tests with post-hoc analysis. Results A total of 56 neurosurgeons responded (42%). Of these, 77% performed more than 10 ACDF and 25% more than 10 PCF annually. An overall preference for ACDF was observed, even when differentiating for a pure disc prolapse, a spondylotic or a combined stenosis. The most relative important factors for motivating the preference for either ACDF or PCF were: the assumed best decompression of the nerve root (18%), perceived congruence with current literature (16%), exposure during residency (12%), personal comfort with the procedure (11%), and experience with the technique (11%). Conclusions In this survey, there was an overall preference for ACDF above PCF for the surgical treatment of a foraminal cervical radiculopathy. In addition to subjective factors as “experience” and “ comfort” with the procedure, the respondents often motivated their choice as “the best one according to literature”. As there is currently no evidence about the superiority of any of the procedures in literature, this assumption is remarkable.
Correlation between the efficacy of stem cell therapy to osteonecrosis of the femoral head and cell viability
Authors: Wu ZhanYu , Sun Qi , Liu Ming , Grottkau Brian , He ZhiXu , Zou Qiang , Ye Chuan 
Published: December 2019

Abstract
Background: Osteonecrosis of the femoral head (ONFH) is a common disease that greatly affects the quality of life of patients. Repair of necrotic area is the key to treatment.At present, the combination of stem cell transplantation and decompression is used clinically to promote the repair of necrotic areas through the characteristics of stem cells. However, a considerable number of patients cannot achieve a satisfactory outcome in repairing the femoral head necrotic area. It is very important to find out the reasons for the poor curative effect. The aim of this study was to investigate the correlation between stem cell viability and the repair efficacy of stem cell therapy combined with core decompression to early-stage of ONFH. Methods: A total of 30 patients with idiopathic ONFH were performed core decompression combined with autologous stem cell transplantation. The Harris score (HHS) and necrosis area change of patients before and after operation were observed. The mean value of repair ratio was set as a threshold dividing the patients into group A (ratios greater than the mean value) and group B (ratios less than the mean value). The ultrastructure, proliferative capacity and multidirectional differentiation ability were compared between the groups. Results: At 9 months after surgery, HHS and magnetic resonance imaging (MRI) findings had improved by varying degrees. Based on the repair ratio, i.e., (62.2 ± 27.0) %, 62.2% was set as a threshold dividing the patients into group A and group B. Better repair(Group A) showed faster proliferation efficiency and healthier ultrastructure. The cells of Group A also showed stronger specific staining after osteogenesis and chondrogenesis induced differentiation. The activity of alkaline phosphatase (ALP) was also higher in group A (OD 2.39 ± 0.44 vs 1.85 ± 0.52; P <0.05) after osteogenic differentiation. Conclusions: The quality of implanted stem cells is closely related to the efficacy of this procedure and determines whether the defects of self-repair in the necrotic areas can be corrected to enhance the repair capacity of necrotic tissue and to promote the repair of necrotic areas to achieve the desired therapeutic outcome.
Factors affecting postoperative survival of patients with insufficient union following osteoporotic vertebral fractures and impact of preoperative serum albumin on mortality
Authors: Ohba Tetsuro , Yokomi Hiroshi MD , Koy Kensuke MD , Tanaka Nobuki , Oda Kotaro , H Hirotaka MD 
Published: December 2019

Abstract
Background: Numerous comparative studies of surgical procedures have focused on clinical and radiographical outcomes, as well as the effect of bone fragility on the outcome of spinal surgery; however, insights concerning a long-term risk of mortality or morbidity have been limited. Additionally, the effect of surgical therapy on survival after vertebral compression fractures remains controversial. To evaluate the preoperative factors that affected the long-term survival of patients who underwent spinal surgery for an insufficient union following osteoporotic vertebral fractures (OVF) and to determine long-term mortality. Methods: We retrospectively reviewed the cases of 105 consecutive patients who underwent spinal surgery for OVF. Morbidity was estimated using the Kaplan-Meier method and a log-rank test. To determine which risk factors led to death among the OVF cases, the preoperative backgrounds of patients were analyzed. Kaplan-Meier curves were used to estimate survival based on the preoperative albumin levels of ≤3.5 g/dL (hypoalbuminemia) versus >3.5 mg/dL. Results: The mean follow-up for survival was 4.1 ±0.8 years. Two years after surgery, 15% of patients with OVF had died. The ratio of male-to-female was significantly higher for patients with OVF who died than for those who were still alive. No significant difference in mortality was observed among surgical procedures for OVF. Multivariate analysis revealed that only serum albumin ≤3.5 g/dL was a significant risk factor for long-term postoperative mortality of people with OVF. Conclusions: Preoperative hypoalbuminemia was associated with long-term postoperative mortality following surgery for OVF.
Cross-cultural adaptation and validation of the Romanian Knee disability and Osteoarthritis Outcome Score for Joint Replacement (KOOSJR)
Authors: Florescu Sorin , Vermesan Dinu , Haragus Horia , Patrascu Jenel M , Timar Bogdan , Todor Adrian 
Published: December 2019

Abstract
Aim: To perform validation of the Romanian Knee disability and Osteoarthritis Outcome Score for Joint Replacement (KOOSJR).Method: 96 patients (101 knees) with advanced osteoarthritis (OA) scheduled for total knee replacement completed Romanian translations of KOOSJR and IKDC (International Knee Documentation Committee – subjective knee form) and Euroqol EQ-5D-5L, and the treating physician completed the original knee society score (KSS). Results: Average age was 66.4 (range 50-83) years and male to female ratio 1:3.76. There was moderate correlation between the test-retest (average 4 days) KOOSJR (r=0.618, n=45) and IKDC (r=-0.671, n=99), weak between KOOSJR and EQ-5D-5L Index (r=-0.431, n=100) and VAS (r=-0.364, n=99) and very weak to KSS score (r=-0.133, n=98) and function (r=-0.072, n=97) For the first KOOSJR, Cronbach's alpha was 0.816 and intraclass correlation coefficient (ICC) 0.816 (95% CI 0.755-0.866) for average measures. For the retest, Cronbach's alpha was 0.841 (95% CI 0.760-0.903) for averages.Conclusion: The Romanian Knee disability and Osteoarthritis Outcome Score for Joint Replacement (KOOSJR) is a valid, reliable, consistent and reproducible clinical score for patients with OA requiring arthroplasty.
The complete genome sequence of the nitrile biocatalyst Rhodocccus rhodochrous ATCC BAA-870
Authors: Frederick Joni , Hennessy Fritha , Horn Uli , Cortés Pilar de la Torre , Broek Marcel van den , Strych Ulrich , Willson Richard C. , Hefer Charles A. , Daran Jean-Marc G. , Sewell Trevor , Otten Linda G. , Brady Dean 
Published: December 2019

Abstract
Background
Rhodococci are industrially important soil-dwelling Gram-positive bacteria that are well known for both nitrile hydrolysis and oxidative metabolism of aromatics. Rhodococcus rhodochrous ATCC BAA-870 is capable of metabolising a wide range of aliphatic and aromatic nitriles and amides. The genome of the organism was sequenced and analysed in order to better understand this whole cell biocatalyst.

Results
The genome of R. rhodochrous ATCC BAA-870 is the first Rhodococcus genome fully sequenced using Nanopore sequencing. The circular genome contains 5.9 megabase pairs (Mbp) and includes a 0.53 Mbp linear plasmid, that together encode 7548 predicted protein sequences according to BASys annotation, and 5535 predicted protein sequences according to RAST annotation. The genome contains numerous oxidoreductases, 15 identified antibiotic and secondary metabolite gene clusters, several terpene and nonribosomal peptide synthetase clusters, as well as 6 putative clusters of unknown type. The 0.53 Mbp plasmid encodes 677 predicted genes and contains the nitrile converting gene cluster, including a nitrilase, a low molecular weight nitrile hydratase, and an enantioselective amidase.
Although there are fewer biotechnologically relevant enzymes compared to those found in rhodococci with larger genomes, such as the well-known Rhodococcus jostii RHA1, the abundance of transporters in combination with the myriad of enzymes found in strain BAA-870 might make it more suitable for use in industrially relevant processes than other rhodococci.

Conclusions
The sequence and comprehensive description of the R. rhodochrous ATCC BAA-870 genome will facilitate the additional exploitation of rhodococci for biotechnological applications, as well as enable further characterisation of this model organism. The genome encodes a wide range of enzymes, many with unknown substrate specificities supporting potential applications in biotechnology, including nitrilases, nitrile hydratase, monooxygenases, cytochrome P450s, reductases, proteases, lipases, and transaminases.
An Analysis Model of Protein Mass Spectrometry Data and its Application
Authors: He Pingan , Hou Longao , Tao Hong , Dai Qi , Yao Yuhua 
Published: December 2019

Backgroud:
The impact of cancer in society created the necessity of new and faster
theoretical models for the early diagnosis of cancer.

Methods:
In this work, a mass spectrometry (MS) data analysis method based on the star-like
graph of protein and support vector machine (SVM) was proposed and applied to the ovarian
cancer early classification in the MS data set. Firstly, the MS data is reduced and transformed into
the corresponding protein sequence. Then, the topological indexes of the star-like graph are
calculated to describe each MS data of the cancer sample. Finally, the SVM model is suggested to
classify the MS data.

Results:
Using independent training and testing experiments 10 times to evaluate the ovarian
cancer detection models, the average prediction accuracy, sensitivity, and specificity of the model
were 96.45%, 96.88%, and 95.67%, respectively, for [0,1] normalization data, and 94.43%,
96.25%, and 91.11% for [-1,1] normalization data.

Conclusion:
The model combined with the SELDI-TOF-MS technology has a prospect in early
clinical detection and diagnosis of ovarian cancer.
A Sequential Ensemble Model for Communicable Disease Forecasting
Authors: Sultana Nashreen , Sharma Nonita , Sharma Krishna Pal , Verma Shobhit 
Published: December 2019

Background:Ensemble building is a popular method for improving model accuracy for classification problems as well as regression.Objective:In this research work, we propose a sequential ensemble model to predict the number of incidences for communicable diseases like influenza, hand foot and mouth disease (HFMD), and diarrhea and compare it with applied models for prediction.Methods:The weekly dataset of the three diseases, namely, influenza, HFMD, and diarrhea, are collected from the official government site of Hong Kong from the year 2010 to 2018. The data was preprocessed by taking log transformation and z-score transformation. The proposed sequential ensemble model is applied to the processed dataset to predict future occurrences.Results:The result of the proposed ensemble model is compared against standard support vector regression (SVR) using different error metrics such as root mean square error (RMSE), mean absolute error (MAE) and mean absolute percentage error (MAPE). In the case of all the threedisease datasets, the proposed ensemble model gives better results in comparison to the standard SVR model.Conclusion:The main objective of this research work is to minimize the prediction error; the proposed sequential ensemble model has shown a significant result in terms of prediction errors.
Geminiviruses: Taxonomic Structure and Diversity in Genomic Organization
Authors: Kulshrestha Saurabh , Bhardwaj Abhishek , Vanshika  
Published: December 2019

Background:
Geminiviridae is one of the best-characterized and hence, one of the largest
plant-virus families with the highest economic importance. Its members characteristically have
a circular ssDNA genome within the encapsidation of twinned quasi-icosaheadral virions (18-38 nm
size-range).

Objective:
Construction of a narrative review on geminiviruses, to have a clearer picture of their
genomic structure and taxonomic status.

Methods:
A thorough search was conducted for papers and patents regarding geminiviruses,
where relevant information was used to study their genomic organization, diversity and taxonomic
structure.

Results:
Geminiviruses have been classified into nine genera (viz., genus Begomovirus, Mastrevirus,
Curtovirus, Topocuvirus, Becurtovirus, Turncurtovirus, Capulavirus, Eragrovirus and
Grablovirus) having distinct genomic organizations, host ranges and insect vectors. Genomic organization
of all genera generally shows the presence of 4-6 ORFs encoding for various proteins.
For now, Citrus chlorotic dwarf-associated virus (CCDaV), Camellia chlorotic dwarf-associated
virus (CaCDaV) and few other geminiviruses are still unassigned to any genera. The monopartite
begomoviruses (and few mastreviruses) have been found associated with aplhasatellites and betasatellites
(viz., ~1.3 kb circular ssDNA satellites). Recent reports suggest that deltasatellites potentially
reduce the accumulation of helper-Begomovirus species in host plants. Some patents have
revealed the methods to generate transgenic plants resistant to geminiviruses.

Conclusion:
Geminiviruses rapidly evolve and are a highly diverse group of plant-viruses. However,
research has shown new horizons in tackling the acute begomoviral diseases in plants by
generating a novel bio-control methodology in which deltasatellites can be used as bio-control
agents and generate transgenic plants resistant to geminiviruses.
Tinjauan atas artikel penelitian dan pengembangan pendidikan di Jurnal Keolahragaan
Authors: Ardiyanto Hysa , Fajaruddin Syarief 
Published: December 2019

Relevansi penelitian pendidikan dengan praktik pendidikan masih sering dipandang secara skeptis. Padahal ada jenis penelitian yang dinilai berpotensi menjembatani jurang tersebut, yaitu penelitian dan pengembangan pendidikan. Tampilan kata kunci yang paling banyak digunakan di Jurnal Keolahragaan menunjukkan jenis penelitian ini banyak dipublikasikan. Namun demikian, tinjauan pada artikel yang melaporkan hasil penelitian ini belum dilakukan. Oleh karena itu, studi ini menganalisis artikel-artikel penelitian dan pengembangan di Jurnal Keolahragaan. Metode yang digunakan dalam penelitian ini adalah studi dokumen. Data dikumpulkan melalui penelusuran arsip di situs web Jurnal Keolahragaan. Hasilnya, metode penelitian dan pengembangan memang banyak digunakan dan dilaporkan di jurnal tersebut. Analisis dokumen berupa sampel artikel terpilih menghasilkan temuan berupa: penggunaan istilah ‘model’ yang dapat diperdebatkan, kekurangakuratan dalam penyajian referensi prosedur pengembangan dan prosedur evaluasi yang cenderung pada data-data kuantitatif. A review of the educational research and development articles in Jurnal Keolahragaan AbstractSkeptical feelings about the value of educational research remained. Educational research and development (R&D) as applied research has the potential to bridges the gap between educational research and practice. The keywords tag cloud in the Jurnal Keolahragaan revealed that this type of research is widely conducted. Unfortunately, a review of the R & D articles in this journal had not been carried out. Therefore, this study aims to review R & D articles in Jurnal Keolahragaan. The method used in this research is a document study. Data collected from the journal archive. The result of this study confirmed that R&D was indeed widely used and reported in the journal. The findings from analytical reviews were as follow: the debatable use of the term 'model' which is frequently used, the inaccuracy of the reference used in developmental procedures, and the evaluation procedures dominated by quantitative data.
Differences between male and female mandibular length growth according to panoramic radiograph
Authors: Azhari Azhari , Pramatika Berty , Epsilawati Lusi 
Published: December 2019

Evaluation of the mandible was used for age and sex determination in the forensic field and it established the treatment planning in dentistry. The present study aims to determine mandibular length growth on male and female group aged 9-25 years old using panoramic radiograph. The research was conducted using analytical cross-sectional design method. The subject of this research was 412 panoramic radioraphs of patients aged 9-25 years old. It involved a totalsamples of 207 males and 205 females. This research was conducted from May to October 2017 in RSGM Padjadjaran University Bandung to meassure the length and height of mandibula from the point in condyleus to mentone. The MannWhitney test results showed a significant difference in mandibular length between men and women and no significant difference between the right andleft mandibular length in men and women. There is a difference between male and female mandibular length growth, in which the increase of growth of mandibular length in female is earlier than that of male. Male mandibular length is greater than female.
The effect of intention to act and knowledge of environmental issues on environmental behavior
Authors: Iman Fauzul , Miarsyah Mieke , Sigit Diana Vivanti 
Published: December 2019

Intention to act and environmental issues knowledge has been assumed as the two variables which affect people’s environmental behavior. This study aimed at determining the correlations between variables (i.e. intention to act, environmental issues knowledge, and environmental behavior) on biology teachers in State High Schools of Pandeglang Regency. This survey research used quantitative approach. The sample was 51 teachers chosen using simple random sampling. Meanwhile, the population was 61 teachers in State High Schools of Pandeglang Regency. The data gained were analyzed using path analysis. The results showed that environmental knowledge gives direct impact on environmental behavior with coefficient value was 0.472. The same phenomena were also occurred in the intention to act towards the teachers’ environmental behavior (0.508). In addition, the intention to act was directly influenced by environmental knowledge (0.364), while the environmental behavior was indirectly affected by environmental knowledge (0.185). Thus, the findings of this study can be basic information to determine the most proper strategy to cultivate a good environmental behavior.