bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiographic patency after robotic beating heart totally endoscopic coronary artery bypass grafting facilitated by automated distal anastomotic connectors
Authors: Balkhy Husam H , Nathan Sandeep , Torregrossa Gianluca , Kitahara Hiroto , Nisivaco Sarah , McCrorey Mackenzie , Patel Brooke 
Published: July 2020

Abstract

OBJECTIVES
Robotic totally endoscopic coronary artery bypass (TECAB) on the beating heart has been facilitated in our experience using distal coronary anastomotic connectors. In this study, we retrospectively reviewed graft patency in all robotic TECAB patients who underwent formal angiography at our current institution over a 5-year period.

METHODS
Between July 2013 and June 2018, 361 consecutive patients underwent robotic beating-heart TECAB. Of these patients, 121 had a follow-up angiogram, which assessed graft patency. Eighty-four patients had an angiogram as part of planned hybrid procedures and 37 patients underwent an unplanned angiogram for clinical indications. Retrospective analysis of angiographic patency and clinical outcomes was performed.

RESULTS
The mean Society of Thoracic Surgeons predicted risk of mortality was 1.8%. Single-vessel bypass was performed in 40 (33%) patients and multivessel grafting in 81 (67%). Average flow (ml/min) and pulsatility index in the grafts was 74.7 ± 39.1 and 1.42 ± 0.52, respectively. The number of grafts evaluated was 204 (130 left internal mammary artery and 74 right internal mammary artery grafts). The median time to angiography was 1.0 and 16.0 months and graft patency was 98% and 91% in the hybrid and non-hybrid groups, respectively. Overall graft patency was 95.6% (left internal mammary artery = 96%; right internal mammary artery = 93%). Left internal mammary artery to left anterior descending artery graft patency was 97%. Clinical follow-up was available for 316 (88%) patients at mean 22.5 ± 15.1 months. Freedom from major adverse cardiac events at 2 years was 92%.

CONCLUSIONS
In this consecutive series of patients undergoing formal angiography after robotic single and multivessel TECAB, we found satisfactory graft patency and 2-year clinical outcomes. Longer-term follow-up is warranted.
A Study in First-Episode Psychosis Patients: Does Angiotensin I-Converting Enzyme Activity Associated With Genotype Predict Symptom Severity Reductions After Treatment With Atypical Antipsychotic Risperidone?
Authors: Nani João V , Dal Mas Caroline , Yonamine Camila M , Ota Vanessa K , Noto Cristiano , Belangero Sintia I , Mari Jair J , Bressan Rodrigo , Cordeiro Quirino , Gadelha Ary , Hayashi Mirian A F 
Published: July 2020

Abstract

Background
Our previous studies showed increased angiotensin I-converting enzyme (ACE) activity in chronic schizophrenia patients compared with healthy control (HC) volunteers, and the relevance of combining ACE genotype and activity for predicting schizophrenia was suggested.

Methods
ACE activity was measured in plasma of ACE insertion/deletion (I/D) genotyped HC volunteers (n = 53) and antipsychotic-naïve first-episode psychosis (FEP) patients (n = 45) assessed at baseline (FEB-B) and also after 2 months (FEP-2M) of treatment with the atypical antipsychotic risperidone.

Results
ACE activity measurements showed significant differences among HC, FEP-B, and FEP-2M groups (F = 5.356, df = 2, P = .005) as well as between HC and FEP-2M (post-hoc Tukey’s multiple comparisons test, P = .004). No correlation was observed for ACE activity increases and symptom severity reductions in FEP as assessed by total Positive and Negative Syndrome Scale (r = −0.131, P = .434). FEP subgrouped by ACE I/D genotype showed significant ACE activity increases, mainly in the DD genotype subgroup. No correlation between ACE activity and age was observed in FEP or HC groups separately (r = 0.210, P = .392), but ACE activity level differences observed between these groups were influenced by age.

Conclusions
The importance of measuring the ACE activity in blood plasma, associated with ACE I/D genotyping to support the follow-up of FEP patients, did not show correlation with general symptom amelioration in the present study. However, new insights into the influence of age and I/D genotype for ACE activity changes in FEP individuals upon treatment was demonstrated.
Joint Eigenfunctions for the Relativistic Calogero–Moser Hamiltonians of Hyperbolic Type. III. Factorized Asymptotics
Authors: Hallnäs Martin , Ruijsenaars Simon 
Published: July 2020

Abstract
In the two preceding parts of this series of papers, we introduced and studied a recursion scheme for constructing joint eigenfunctions $J_N(a_+, a_-,b;x,y)$ of the Hamiltonians arising in the integrable $N$-particle systems of hyperbolic relativistic Calogero–Moser type. We focused on the 1st steps of the scheme in Part I and on the cases $N=2$ and $N=3$ in Part II. In this paper, we determine the dominant asymptotics of a similarity-transformed function $\textrm{E}_N(b;x,y)$ for $y_j-y_{j+1}\to \infty $, $j=1,\ldots , N-1$ and thereby confirm the long-standing conjecture that the particles in the hyperbolic relativistic Calogero–Moser system exhibit soliton scattering. This result generalizes a main result in Part II to all particle numbers $N&gt;3$.
Cystatin C and Urine Albumin to Creatinine Ratio Predict 5-Year Mortality and Cardiovascular Events in People Living With HIV
Authors: Chazot Robin , Botelho-Nevers Elisabeth , Mariat Christophe , Frésard Anne , Cavalier Etienne , Lucht Frédéric , Delanaye Pierre , Maillard Nicolas , Gagneux-Brunon Amandine 
Published: July 2020

Abstract

Background
Identifying people with HIV (PWH) at risk for chronic kidney disease, cardiovascular events, and death is crucial. We evaluated biomarkers to predict all-cause mortality and cardiovascular events, and measured glomerular filtration rate (mGFR) slope.

Methods
Biomarkers were measured at enrollment. Baseline and 5-year mGFR were measured by plasma iohexol clearance. Outcomes were a composite criterion of all-cause mortality and/or cardiovascular events, and mGFR slope.

Results
Of 168 subjects, 146 (87.4%) had undetectable HIV load. Median follow-up was 59.1 months (interquartile range, 56.2–62.1). At baseline, mean age was 49.5 years (± 9.8) and mean mGFR 98.9 mL/min/1.73m2 (± 20.6). Seventeen deaths and 10 cardiovascular events occurred during 5-year follow-up. Baseline mGFR was not associated with mortality/cardiovascular events. In multivariable analysis, cystatin C (hazard ratio [HR], 5.978; 95% confidence interval [CI], 2.774–12.88; P &lt; .0001) and urine albumin to creatinine ratio (uACR) at inclusion (HR, 1.002; 95% CI, 1.001–1.004; P &lt; .001) were associated with mortality/cardiovascular events. Area under receiver operating curve of cystatin C was 0.67 (95% CI, .55–.79) for mortality/cardiovascular event prediction. Biomarkers were not associated with GFR slope.

Conclusions
uACR and cystatin C predict all-cause mortality and/or cardiovascular events in PWH independently of mGFR.
Efficacy of human-simulated exposures of meropenem/vaborbactam and meropenem against OXA-48 β-lactamase-producing Enterobacterales in the neutropenic murine thigh infection model
Authors: Gill Christian M , Asempa Tomefa E , Nicolau David P 
Published: July 2020

Abstract

Objectives
Despite vaborbactam lacking inhibitory activity against OXA-48, approximately a third of OXA-48-harbouring Enterobacterales test susceptible to meropenem/vaborbactam due to its higher breakpoint than meropenem alone. The present study evaluated the efficacy of human-simulated exposures of meropenem/vaborbactam against OXA-48-harbouring Enterobacterales in the neutropenic murine thigh model.

Methods
Twenty-six isolates [OXA-48 (n = 24) and KPC (n = 2)] were evaluated. MICs were conducted in triplicate per CLSI. Mice received human-simulated regimens of meropenem/vaborbactam, meropenem or vehicle for 24 h. Mice were inoculated with ∼1 × 107 cfu/mL in each thigh 2 h prior to dosing and both thighs were harvested at 24 h. Efficacy was assessed using mean log10 cfu/thigh at 24 h and the achievement of 1 log10 reduction relative to 0 h control as an established surrogate marker predictive of success for serious infections.

Results
Meropenem/vaborbactam MICs ranged from 1 to 64 mg/L. The mean inoculum at 0 h was 5.77 ± 0.26 compared with 8.26 ± 1.53 for controls at 24 h. As anticipated for KPCs, meropenem/vaborbactam resulted in enhanced mean ± SD change in bacterial density (−1.10 ± 0.26), compared with meropenem (1.45 ± 0.88). Vaborbactam did not enhance mean ± SD change against OXA-48 isolates compared with meropenem (−0.44 ± 1.29 and −0.43 ± 1.36, respectively). For OXA-48-harbouring isolates with meropenem/vaborbactam MICs ≥16 (n = 5), 8 (n = 5), 4 (n = 9) and ≤2 (n = 5) mg/L, 0%, 0%, 44% and 60% of isolates achieved the target reduction ≥1 log10 with either agent, respectively.

Conclusions
These data highlight that meropenem/vaborbactam and meropenem humanized exposures in vivo resulted in similar, albeit poor, activity against OXA-48-producing Enterobacterales despite susceptible MICs per EUCAST and CLSI interpretation. As a result, caution is warranted when treating meropenem/vaborbactam-susceptible Enterobacterales without a genotypic profile.
The Effects of High-Altitude Windborne Migration on Survival, Oviposition, and Blood-Feeding of the African Malaria Mosquito, Anopheles gambiae s.l. (Diptera: Culicidae)
Authors: Sanogo Zana L , Yaro Alpha S , Dao Adama , Diallo Moussa , Yossi Ousman , Samaké Djibril , Krajacich Benjamin J , Faiman Roy , Lehmann Tovi 
Published: July 2020

AbstractRecent results of high-altitude windborne mosquito migration raised questions about the viability of these mosquitoes despite ample evidence that many insect species, including other dipterans, have been known to migrate regularly over tens or hundreds of kilometers on high-altitude winds and retain their viability. To address these concerns, we subjected wild Anopheles gambiae s.l. Giles mosquitoes to a high-altitude survival assay, followed by oviposition (egg laying) and blood feeding assays. Despite carrying out the survival assay under exceptionally harsh conditions that probably provide the lowest survival potential following high altitude flight, a high proportion of the mosquitoes survived for 6- and even 11-h assay durations at 120- to 250-m altitudes. Minimal differences in egg laying success were noted between mosquitoes exposed to high altitude survival assay and those kept near the ground. Similarly, minimal differences were found in the female’s ability to take an additional bloodmeal after oviposition between these groups. We conclude that similar to other high-altitude migrating insects, mosquitoes are able to withstand extended high-altitude flight and subsequently reproduce and transmit pathogens by blood feeding on new hosts.
Growth, phenology and N-utilization by invasive populations of Gunnera tinctoria
Authors: Mantoani Maurício Cruz , González Alberto Benavent , Sancho Leopoldo García , Osborne Bruce Arthur 
Published: July 2020

AbstractAimsGunnera tinctoria is an unusual N-fixing plant species that has become invasive worldwide, generally in environments with a low evaporative demand and/or high rainfall. Amongst the many mechanisms that may explain its success as an introduced species, a contrasting phenology could be important but this may depend on an ability to grow and utilize nutrients under sub-optimal conditions. We examined whether G. tinctoria has an advantage in terms of a contrasting phenology and N-fixing capability, in comparisons with Juncus effusus, the native species most impacted by G. tinctoria invasions.MethodsWe made phenological assessments on a weekly or bi-weekly basis on long-established populations on Achill Island, Ireland, during 2016–2017. Data on leaf and inflorescence number, total leaf area, light interception and above-ground biomass were collected alongside measurements of soil temperature, moisture and oxidation–reduction potential. The significance of N-fixing ability for supporting seasonal growth was assessed using δ 15N isotopic assessments, together with in situ acetylene reduction measurements.Important FindingsThe timing of the initiation of growth of G. tinctoria and J. effusus varied between 2016 and 2017, with the earlier emergence and expansion of leaves of G. tinctoria, and the largest above-ground biomass associated with higher water availability. The early growth of G. tinctoria was dependent on preformed structures, with maximum canopy development occurring in late May, prior to that of J. effusus. Whilst N-fixation was observed in March, this made a more significant contribution to growth during the later stages of canopy development. Based on δ 15N isotopic analyses, early growth was predominantly associated with N-remobilization from the rhizomes, whilst seedlings were largely reliant on N-fixation. This emphasizes the importance of nutrient mobilization for early growth and shows that the importance of an N-fixing capability may vary developmentally, as well as during different stages of the invasion process.
The Role of Caregiver-Reported Risks in Predicting Adverse Pediatric Outcomes
Authors: Vaz Louise E , Wagner David V , Jungbauer Rebecca M , Ramsey Katrina L , Jenisch Celeste , Koskela-Staples Natalie , Everist Steven , Austin Jared P , Harris Michael A , Zuckerman Katharine E 
Published: July 2020

AbstractObjectiveCertain social risk factors (e.g., housing instability, food insecurity) have been shown to directly and indirectly influence pediatric health outcomes; however, there is limited understanding of which social factors are most salient for children admitted to the hospital. This study examines how caregiver-reported social and medical characteristics of children experiencing an inpatient admission are associated with the presence of future health complications.MethodsCaregivers of children experiencing an inpatient admission (N = 249) completed a predischarge questionnaire designed to capture medical and social risk factors across systems (e.g., patient, caregiver, family, community, healthcare environment). Electronic health record (EHR) data were reviewed for child demographic data, chronic disease status, and subsequent emergency department visits or readmissions (i.e., acute events) 90 days postindex hospitalization. Associations between risk factors and event presence were estimated using odds ratios (ORs) and confidence intervals (CI), both unadjusted and adjusted OR (aOR) for chronic disease and age.ResultsThirty-three percent (N = 82) of children experienced at least one event. After accounting for child age and chronic disease status, caregiver perceptions of child’s health being generally “poor” or “not good” prior to discharge (aOR = 4.7, 95% CI = 2.3, 9.7), having high care coordination needs (aOR = 3.2, 95% CI = 1.6, 6.1), and experiencing difficulty accessing care coordination (aOR = 2.5, 95% CI = 1.4, 4.7) were significantly associated with return events.ConclusionsCaregiver report of risks may provide valuable information above and beyond EHR records to both determine risk of future health problems and inform intervention development.
The diverse and unanticipated roles of histone deacetylase 9 in coordinating plant development and environmental acclimation
Authors: de Rooij Peter G H , Perrella Giorgio , Kaiserli Eirini , van Zanten Martijn 
Published: July 2020

Abstract
Plants tightly control gene transcription to adapt to environmental conditions and steer growth and development. Different types of epigenetic modifications are instrumental in these processes. In recent years, an important role for the chromatin-modifying RPD3/HDA1 class I HDAC HISTONE DEACETYLASE 9 (HDA9) emerged in the regulation of a multitude of plant traits and responses. HDACs are widely considered transcriptional repressors and are typically part of multiprotein complexes containing co-repressors, DNA, and histone-binding proteins. By catalyzing the removal of acetyl groups from lysine residues of histone protein tails, HDA9 negatively controls gene expression in many cases, in concert with interacting proteins such as POWERDRESS (PWR), HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 15 (HOS15), WRKY53, ELONGATED HYPOCOTYL 5 (HY5), ABA INSENSITIVE 4 (ABI4), and EARLY FLOWERING 3 (ELF3). However, HDA9 activity has also been directly linked to transcriptional activation. In addition, following the recent breakthrough discovery of mutual negative feedback regulation between HDA9 and its interacting WRKY-domain transcription factor WRKY53, swift progress in gaining understanding of the biology of HDA9 is expected. In this review, we summarize knowledge on this intriguing versatile—and long under-rated—protein and propose novel leads to further unravel HDA9-governed molecular networks underlying plant development and environmental biology.
Abiotic stress signalling in extremophile land plants
Authors: Boulc’h Pierre-Nicolas , Caullireau Emma , Faucher Elvina , Gouerou Maverick , Guérin Amandine , Miray Romane , Couée Ivan 
Published: July 2020

AbstractPlant life relies on complex arrays of environmental stress sensing and signalling mechanisms. Extremophile plants develop and grow in harsh environments with extremes of cold, heat, drought, desiccation, or salinity, which have resulted in original adaptations. In accordance with their polyphyletic origins, extremophile plants likely possess core mechanisms of plant abiotic stress signalling. However, novel properties or regulations may have emerged in the context of extremophile adaptations. Comparative omics of extremophile genetic models, such as Arabidopsis lyrata, Craterostigma plantagineum, Eutrema salsugineum, and Physcomitrella patens, reveal diverse strategies of sensing and signalling that lead to a general improvement in abiotic stress responses. Current research points to putative differences of sensing and emphasizes significant modifications of regulatory mechanisms, at the level of secondary messengers (Ca2+, phospholipids, reactive oxygen species), signal transduction (intracellular sensors, protein kinases, transcription factors, ubiquitin-mediated proteolysis) or signalling crosstalk. Involvement of hormone signalling, especially ABA signalling, cell homeostasis surveillance, and epigenetic mechanisms, also shows that large-scale gene regulation, whole-plant integration, and probably stress memory are important features of adaptation to extreme conditions. This evolutionary and functional plasticity of signalling systems in extremophile plants may have important implications for plant biotechnology, crop improvement, and ecological risk assessment under conditions of climate change.
Ethylene functions as a suppressor of volatile production in rice
Authors: Mujiono Kadis , Tohi Tilisa , Sobhy Islam S , Hojo Yuko , Ho Nhan Thanh , Shinya Tomonori , Galis Ivan 
Published: July 2020

AbstractWe examined the role of ethylene in the production of rice (Oryza sativa) volatile organic compounds (VOCs), which act as indirect defense signals against herbivores in tritrophic interactions. Rice plants were exposed to exogenous ethylene (1 ppm) after simulated herbivory, which consisted of mechanical wounding supplemented with oral secretions (WOS) from the generalist herbivore larva Mythimna loreyi. Ethylene treatment highly suppressed VOCs in WOS-treated rice leaves, which was further corroborated by the reduced transcript levels of major VOC biosynthesis genes in ethylene-treated rice. In contrast, the accumulation of jasmonates (JA), known to control VOCs in higher plants, and transcript levels of primary JA response genes, including OsMYC2, were not largely affected by ethylene application. At the functional level, flooding is known to promote internode elongation in young rice via ethylene signaling. Consistent with the negative role of ethylene on VOC genes, the accumulation of VOCs in water-submerged rice leaves was suppressed. Furthermore, in mature rice plants, which naturally produce less volatiles, VOCs could be rescued by the application of the ethylene perception inhibitor 1-methylcyclopropene. Our data suggest that ethylene acts as an endogenous suppressor of VOCs in rice plants during development and under stress.
Gamma-ray flux depressions of the Crab Nebula in the high-energy range
Authors: Pshirkov M S , Nizamov B A , Bykov A M , Uvarov Yu A 
Published: July 2020

ABSTRACT
The giant gamma-ray flares of the Crab Nebula discovered by AGILE and Fermi observatories came as a surprise and have challenged the existing models of pulsar wind nebulae. We have carried out an analysis of 10.5 yr of Fermi-LAT observations (August 2008 to February 2019) and investigated variability of the Crab Nebula in the 100–300 MeV range. Besides the flares, we found several month long depressions of the gamma-ray flux and identified several cases of sharp flux drops, where during 1 week the flux decreased by an order of magnitude with respect to its average value. No statistically significant variations of the nebula flux in the E &gt; 10 GeV range were found in the data. We discuss possible implications of the observed gamma-ray flux depressions on the model of synchrotron emission of the Crab Nebula.
On the gamma-ray signals from UCMH/mini-spike accompanying the DAMPE 1.4 TeV e+e− excess
Authors: Cheng Ji-Gui , Li Shang , Gan Ying-Ying , Liang Yun-Feng , Lu Rui-Jing , Liang En-Wei 
Published: July 2020

ABSTRACT
The tentative 1.4 TeV e+e− excess observed by DAMPE, if not a statistical fluctuation, may be explained by dark matter (DM) annihilation within a nearby subhalo with a distance of &lt;0.3 kpc. The process of DM annihilating to e+e− is accompanied by the production of gamma-ray photons, which could lead to detectable signals of Fermi-LAT. In this work, we focus on the model that the tentative 1.4 TeV signal is from a nearby ultracompact mini halo (UCMH). Due to the small angular extension, the counterpart gamma-ray signal would be hidden among Fermi-LAT unassociated point sources. We examine the point sources in 4FGL systematically by analyzing the Fermi-LAT data, aiming to investigate whether there exist sources with gamma-ray properties consistent with the UCMH model of the 1.4 TeV excess. We find more than 10 sources could be the candidates. Furthermore, we test the possibility that the excess signal is from a DM mini-spike around the nearest BH, but our result does not favour such a scenario.
The roles of polycyclic aromatic hydrocarbons in dark cloud chemistry: new constraints on sulphur-bearing species
Authors: Ge Jixing , Mardones Diego , Inostroza Natalia , Peng Yaping 
Published: July 2020

ABSTRACT
The recent detection of c-C6H5CN in the dark cloud TMC-1 provides a new evidence of polycyclic aromatic hydrocarbons (PAHs) in dark clouds. However, knowledge of PAHs in dark cloud chemistry is still very limited. In this study, we investigate the effects of PAHs on the chemistry in dark clouds by coupling published PAH-related chemistry with a gas–grain reaction network. We found that abundances of some ice species, such as OCS, OCN, C2H5OH and HCOOCH3, are enhanced by more than two orders of magnitude due to the inclusion of PAHs in the gas–grain chemistry through accretion and subsequent reactions in ice. Especially, combining PAHs with gas–grain chemistry in dark clouds provides an alternative way to reach a good overall agreement of sulphur-bearing species in both the gas and solid phases using the cosmic value of sulphur. With the inclusion of PAHs, CS + O $\longrightarrow$ OCS makes a contribution of ∼5–10 per cent to solid-phase OCS together with CO + S $\longrightarrow$ OCS (∼80−90 per cent), depending on the initial abundances, chemical age and PAH parameters.