bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic literature review of spinal brace/orthosis treatment for adults with scoliosis between 1967 and 2018: clinical outcomes and harms data
Authors: McAviney Jeb , Mee Johanna , Fazalbhoy Azharuddin , Du Plessis Juan , Brown Benjamin T. 
Published: February 2020

Abstract
Background
There is a paucity of literature regarding the conservative management of adult scoliosis. The authors review and summarize the literature from 1967 to 2018 on the clinical outcomes of spinal brace/orthosis use in this subgroup of the population.

Methods
CINAHL, Embase, CENTRAL, PubMed and PEDro were searched from database inception to the 30th of October, 2018. A combination of medical subject heading terms and keywords pertaining to three core concepts (adult, scoliosis, and braces/orthoses) were used in the search. Studies were included if A) clinical outcomes were collected from B) participants ≥18 years C) receiving spinal brace/orthosis treatment for D) primary degenerative (de novo) scoliosis or progressive idiopathic scoliosis. A step-wise screening process was employed which involved a title and abstract screen for relevancy followed by a full text eligibility appraisal by two authors. Data were extracted, and a risk of bias assessment was performed on the included cohort studies using the Newcastle-Ottawa Scale. Given the overall level and quality of the available evidence, conclusions were drawn based on a qualitative summary of the evidence.

Results
Ten studies (four case reports and six cohort studies) were included which detailed the clinical outcomes of soft (2 studies) or rigid bracing (8 studies), used as a standalone therapy or in combination with physiotherapy/rehabilitation, in 339 adults with various types of scoliosis. Most studies included female participants only. Commonly reported outcomes were pain (7 studies), function (3 studies) and Cobb angles (3 studies), with follow-up times ranging from 2 days to 17 years. Brace wear prescriptions ranged from 2 to 23 h per day, and there was mixed brace-compliance reported. Most studies reported modest or significant reduction in pain and improvement in function at follow-up. There were mixed findings with regards to Cobb angle changes in response to bracing. Participants from one study noted discomfort associated with bracing. Each of the six cohort studies demonstrated a high risk of bias.

Conclusion
There is evidence to suggest that spinal brace/orthosis treatment may have a positive short – medium term influence on pain and function in adults with either progressive primary (de novo) degenerative scoliosis or progressive idiopathic scoliosis. At this point in time the evidence is of low quality and has been focused primarily on female patients with thoracolumbar and lumbar curves. More granular statements regarding the efficacy of different brace types or manufacturers, or the effect of this therapy on different curve types cannot be determined based on the current literature. Properly constructed prospective trials are required to better understand the efficacy of bracing in adult scoliosis.
Epidemiology, classification, treatment and mortality of distal radius fractures in adults: an observational study of 23,394 fractures from the national Swedish fracture register
Authors: Rundgren Johanna , Bojan Alicja , Mellstrand Navarro Cecilia , Enocson Anders 
Published: February 2020

Abstract
Background
Distal radius fractures are the most common of all fractures. Optimal treatment is still debated. Previous studies report substantial changes in treatment trends in recent decades. Few nation-wide studies on distal radius fracture epidemiology and treatment exist, none of which provide detailed data on patient and injury characteristics, fracture pattern and mortality. The aim of this study was to describe the epidemiology, fracture classification, current treatment regimens and mortality of distal radius fractures in adults within the context of a large national register study.

Methods
We performed a descriptive study using prospectively registered data from the Swedish fracture register. Included were all non-pathological distal radius fractures registered between January 1st 2015 and December 31st 2017 in patients aged 18 years and above. Nominal variables were presented as proportions of all registered fractures.

Results
A total of 23,394 distal radius fractures in 22,962 patients were identified. The mean age was 62.7 ± 17.6 years for all, 65.4 ± 16.0 for women and 53.6 ± 20.0 for men. A simple fall was the most common cause of injury (75%, n = 17,643/23,394). One third (33%, n = 7783/21,723) of all fractures occurred at the patients’ residence. 65% (n = 15,178/23,394) of all fractures were classified as extra-articular AO-23-A, 12% (n = 2770/23,394) as partially intra-articular AO-23-B and 23% (n = 5446/23,394) as intra-articular AO-23-C. The primary treatment was non-surgical for 74% (n = 17,358/23,369) and surgical for 26% (n = 6011/23,369) of all fractures. Only 18% of the AO-23-A fractures were treated surgically, compared to 48% of the AO-23-C fractures. The most frequently used surgical method was plate fixation (82%, n = 4954/5972), followed by pin/wire fixation (8.2%, n = 490/5972), external fixation (4.8%, n = 289/5972) and other methods (4.0%, n = 239/5972). The overall 30-day mortality was 0.4% (n = 98/23,394) and the 1-year mortality 2.9% (n = 679/23,394).

Conclusion
This nation-wide observational study provides comprehensive data on the epidemiology, fracture classification and current treatment regimens of distal radius fractures in a western European setting. The most common patient was an eldery woman who sustained a distal radius fracture through a simple fall in her own residence, and whose fracture was extra-articluar and treated non-surgically.
Load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction
Authors: Connelly Kim A. , Zhang Yanling , Desjardins Jean-François , Nghiem Linda , Visram Aylin , Batchu Sri N. , Yerra Verra G. , Kabir Golam , Thai Kerri , Advani Andrew , Gilbert Richard E. 
Published: February 2020

Abstract
Background and aims
Sodium–glucose linked cotransporter-2 (SGLT2) inhibitors reduce the likelihood of hospitalization for heart failure and cardiovascular death in both diabetic and non-diabetic individuals with reduced ejection fraction heart failure. Because SGLT2 inhibitors lead to volume contraction with reductions in both preload and afterload, these load-dependent factors are thought to be major contributors to the cardioprotective effects of the drug class. Beyond these effects, we hypothesized that SGLT2 inhibitors may also improve intrinsic cardiac function, independent of loading conditions.

Methods
Pressure–volume (P–V) relationship analysis was used to elucidate changes in intrinsic cardiac function, independent of alterations in loading conditions in animals with experimental myocardial infarction, a well-established model of HFrEF. Ten-week old, non-diabetic Fischer F344 rats underwent ligation of the left anterior descending (LAD) coronary artery to induce myocardial infarction (MI) of the left ventricle (LV). Following confirmation of infarct size with echocardiography 1-week post MI, animals were randomized to receive vehicle, or the SGLT2 inhibitor, empagliflozin. Cardiac function was assessed by conductance catheterization just prior to termination 6 weeks later.

Results
The circumferential extent of MI in animals that were subsequently randomized to vehicle or empagliflozin groups was similar. Empagliflozin did not affect fractional shortening (FS) as assessed by echocardiography. In contrast, load-insensitive measures of cardiac function were substantially improved with empagliflozin. Load-independent measures of cardiac contractility, preload recruitable stroke work (PRSW) and end-systolic pressure volume relationship (ESPVR) were higher in rats that had received empagliflozin. Consistent with enhanced cardiac performance in the heart failure setting, systolic blood pressure (SBP) was higher in rats that had received empagliflozin despite its diuretic effects. A trend to improved diastolic function, as evidenced by reduction in left ventricular end-diastolic pressure (LVEDP) was also seen with empagliflozin. MI animals treated with vehicle demonstrated myocyte hypertrophy, interstitial fibrosis and evidence for changes in key calcium handling proteins (all p < 0.05) that were not affected by empagliflozin therapy.

Conclusion
Empagliflozin therapy improves cardiac function independent of loading conditions. These findings suggest that its salutary effects are, at least in part, due to actions beyond a direct effect of reduced preload and afterload.
FOXM 1 induces Vasculogenic mimicry in esophageal cancer through β-catenin /Tcf4 signaling
Authors: Cheng Lili , Wang Qi , Tao Xiaoying , Qin Yanzi , Wu Qiong , Zheng Dafang , Chai Damin , Zhang Yong , Lu Dongbing , Ci Hongfei , Wang Zhiwei , Ma Jia , Wang Danna , Cheng Zenong , Wu Shiwu , Tao Yisheng 
Published: February 2020

Abstract
Objective
To investigate the role of FOXM1, β-catenin and TCF4 in esophageal cancer (EC) and their relationship to VM (Vasculogenic Mimicry).

Methods
CCK-8 were performed to examine EC cell proliferation in FOXM1 silenced cells. EC cell migration and invasion were investigated through wound healing and Transwell assays, respectively. The formation of pipe like structures were assessed in 3D cultures. The expression of Foxm1, β-catenin, Tcf4 and E-cadherin were investigated through western blot, RT-qPCR and immunohistochemistry (IHC) staining. The relationship between FOXM1 expression, clinic-pathological features, and overall survival (OS) were further analyzed.

Results
A loss of FOXM1 expression correlated with the OS of ESCC patients. FOXM1 silencing led to a loss of cell growth and suppressed cell migration and invasion in ESCC cells. VM structures were identified in ESCC tissues and human EC cell lines. Mechanistically, FOXM1 was found to promote tumorigenesis through the regulation of β-catenin, Tcf4, and E-cadherin in EC cells, leading to the formation of VM structures.

Conclusions
These findings highlight FoxM1 as a novel therapeutic target in ESCC.
Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis
Authors: Hayashi Toshitetsu , Hirokawa Mitsuyoshi , Kuma Seiji , Higuchi Miyoko , Suzuki Ayana , Kanematsu Risa , Kudo Takumi , Katsuki Naomi , Haba Reiji , Miyauchi Akira 
Published: February 2020

Abstract
Background
Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease.

Methods
We analyzed the clinicopathological features of thyroid BL by conducting a meta-analysis of 21 known patients (including ours) and compared them to those of extrathyroidal BL.

Results
There were 13 men and 8 women with a median age of 39.3 years (range, 6–75 years). The median follow-up was 46.5 months (range, 0.5–361 months). Six patients (28.6%) had stage I disease, 2 (9.5%) had stage II, 2 (9.5%) had stage III, and 11 (52.4%) had stage IV. Five of 7 tested patients with thyroid BL (71.4%) had histological evidence of underlying Hashimoto’s thyroiditis. Ki-67 labeling indices exceeding 90% in all 19 patients tested (100%). Fluorescence in situ hybridization performed on 12 patient samples revealed that all (100%) had MYC rearrangement. Among the 16 patients for whom follow-up data were available, 4 died of disease-related causes. Kaplan-Meier analysis revealed that the 12- and 60-month overall survival rates for patients with thyroid BL were 87.5 and 70.7%, respectively.

Conclusions
Ours was the largest study of thyroid BL and its detailed clinicopathological features to date. Thyroid BL is not associated with underlying Epstein-Barr virus infection but is closely linked to Hashimoto’s thyroiditis; patients generally have good overall survival and respond well to intensive chemotherapy. The correct pathological diagnosis is essential for treatment selection and outcome improvement.
Optimal location of a thin rigid inclusion for a problem describing equilibrium of a composite Timoshenko plate with a crack
Authors: Lazarev Nyurgun , Romanova Natalyya , Semenova Galina 
Published: February 2020

AbstractWe consider equilibrium problems for a cracked composite plate with a thin cylindrical rigid inclusion. Deformation of an elastic matrix is described by the Timoshenko model. The plate is assumed to have a through crack that does not touch the rigid inclusion. In order to describe mutual nonpenetration of the crack faces we impose a boundary condition in the form of inequality on the crack curve. For a family of appropriate variational problems, we analyze the dependence of their solutions on the location of the rigid inclusion. We formulate an optimal control problem with a cost functional defined by an arbitrary continuous functional on the solution space, while the location parameter of inclusion is chosen as the control parameter. The existence of a solution to the optimal control problem and a continuous dependence of the solutions in a suitable Sobolev space with respect to the location parameter are proved.
Mesh-adapted stress analysis of multilayered plates using a layerwise model
Authors: Salha Lucille , Bleyer Jérémy , Sab Karam , Bodgi Joanna 
Published: February 2020

AbstractThis paper proposes a new finite-element modelling of a recent layerwise model for multilayered plates. This layerwise model is built from a specific 3D stress-field expansion along the thickness direction and involves, in particular, interlaminar transverse shear and out-of-plane stresses as generalized stresses. Its main feature is that 3D equilibrium equations and free-edge boundary conditions are directly taken into account into the stress-based construction of the model. A dual displacement-based finite-element discretization is implemented using the FEniCS software package and a remeshing strategy is proposed based on a novel error indicator. The error indicator is built based on the 3D stress field directly deduced from the layerwise generalized stresses and compared to a reconstructed stress field based on the model generalized displacements. The proposed error indicator is shown to identify the most critical parts of a laminate structure associated with complex 3D stress fields such as boundaries or stress concentration/singularity regions (near free-edges or delamination fronts). Through the combination of thickness discretization and in-plane mesh refinement in regions of interest, the proposed framework therefore offers an attractive alternative to 3D solid finite elements for an accurate prediction of stress states in composite laminates.
“It’s like heaven over there”: medicine as discipline and the production of the carceral body
Authors: Glenn Jason E. , Bennett Alina M. , Hester Rebecca J. , Tajuddin Nadeem N. , Hashmi Ahmar 
Published: February 2020

AbstractBackgroundCorrectional systems in several U.S. states have entered into partnerships with Academic Medical Centers (AMCs) to provide healthcare for people who are incarcerated. This project was initiated to better understand medical trainee perspectives on training and providing healthcare services to prison populations at one AMC specializing in the care of incarcerated patients: The University of Texas Medical Branch at Galveston (UTMB). We set out to characterize the attitudes and perceptions of medical trainees from the start of their training until the final year of Internal Medicine residency. Our goal was to analyze medical trainee perspectives on caring for incarcerated patients and to determine what specialized education and training is needed, if any, for the provision of ethical and appropriate healthcare to incarcerated patients.ResultsWe found that medical trainees grapple with being beneficiaries of a state and institutional power structure that exploits the neglected health of incarcerated patients for the benefit of medical education and research. The benefits include the training opportunities afforded by the advanced pathologies suffered by persons who are incarcerated, an institutional culture that generally allowed students more freedom to practice their skills on incarcerated patients as compared to free-world patients, and an easy compliance of incarcerated patients likely conditioned by their neglect. Most trainees failed to recognize the extreme power differential between provider and patient that facilitates such freedom.ConclusionsUsing a critical prison studies/Foucauldian theoretical framework, we identified how the provision/withholding of healthcare to and from persons who are incarcerated plays a major role in disciplining incarcerated bodies into becoming compliant medical patients and research subjects, complacent with and even grateful for delayed care, delivered sometimes below the standard best practices. Specialized vulnerable-population training is sorely needed for both medical trainees and attending physicians in order to not further contribute to this exploitation of incarcerated patients.
Exo- and endoglucanase production by Curvularia affinis using bean (Phaseolus vulgaris L.) waste biomass
Authors: Alawlaqi M. M. , Alharbi Asmaa A. 
Published: February 2020

AbstractBackgroundIn many countries, agricultural residues are generated in large quantities, and most of these are underutilized and considered waste, especially in developing countries.ResultIn this study,Curvularia affiniswas isolated from the leaves ofPhaseolus vulgarisL. beans and identified using 18S rRNA sequencing.C. affiniswas tested for exo- and endoglucanase production using biomass of bean waste compared with the use of microcrystalline cellulose (MCC) and carboxymethylcellulose (CMC) as its growth substrates.C. affiniswas better able to produce exo- and endoglucanase enzymes on bean waste biomass than on MCC and CMC. The highest activities of exo- and endoglucanase were detected with substrate concentrations 2% using MCC or CMC and with 4% using bean waste. The optimum incubation period for enzymes activity was 6 days with MCC or CMC (activity was 5.90 and 2.99 U/g of exoglucanase and endoglucanase, respectively) and 8 days with bean waste where activity was 3.64 U/g and 0.92 U/g of exoglucanase and endoglucanase, respectively. Exo- and endoglucanase production showed the highest activity at pH 5–6. In process wherein surfactant (Tween 80) was used, the exoglucanase activity gradually increased from 5.92 U/g to 6.20 U/g and then decreased to 5.70 U/g at 0.50% compared with that using the MCC substrate. The exoglucanase activity gradually increased from 3.80 U/g at 0.0% to 4.12 U/g at 0.20% and then decreased to 3.01 U/g at 0.50% Tween 80 using bean waste. Pretreated bean biomass also yielded higher enzyme production than the non-pretreated biomass. Alkaline-pretreated biomass showed the highest enzyme production compared with acid-treated residues, followed by the H2O2-treated ones.ConclusionThe study concluded thatC. affinisproduce exo- and endoglucanase enzymes using cheap and abundant biomass of beans. Moreover, optimization of enzymes indicated that pretreatment of biomass bean biomass is a good choice process for enhanced enzymes productivity.
Spatial distribution and sources of tsunami deposits in a narrow valley setting - insight from 2011 Tohoku-oki tsunami deposits in northeastern Japan
Authors: Abe Tomoya , Goto Kazuhisa , Sugawara Daisuke 
Published: February 2020

AbstractSedimentary processes and spatial distributions of tsunami deposits in valleys have poorly been understood despite many paleo-tsunami deposits have recently been discovered from sedimentary sequences in valleys. We conducted an exhaustive investigation of 2011 Tohoku-oki tsunami deposits in a narrow valley at the south end of Sendai Plain, northeastern Japan, to collect sedimentological data of the tsunami deposits in the valley and to correlate them with tsunami inundation and associated sedimentary processes. The tsunami deposits were investigated at 174 sites to cover the entire inundation area of the narrow valley. We analyzed thickness, sedimentary structures, and grain size of the tsunami deposits to correlate their spatial variation with tsunami flow hydrodynamics and topographic features. The tsunami deposits, composed of sand and mud layers, were found to be 0–40 cm thick. Sand thickness generally decreased inland with local fluctuation. The sand layer was mostly composed of single unit on the upper main valley and sub-valleys, although it was mainly composed of 2–6 sub-units on the lower main valley and in the pond. Mud thickness is strongly controlled by local sources, namely, the rice paddy and the pond. The depositional area of the mud layer coincides with the distribution of the rice paddies and the pond location. The mud layer also considerably thicker in and around the pond. These results indicate that sediment thickness and sedimentary structures are highly varied on a local scale, but they are generally controlled by local topography. Sediment budget in the valley was estimated, and it may provide implications to general sedimentary process. Total depositional volume of the tsunami sand deposited on land is half of the volume of sediments disappeared from the sandy beach and sand dune, suggesting the rest must have been discharged into the sea by the backwash. Spatial distribution of sediment thickness and sedimentary structures as well as sedimentary processes inferred from 2011 Tohoku-oki tsunami deposits will benefit searching and identification of paleo-tsunami deposits in valleys of other coastal environments.