bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregivers’ Feeding Behavior, Children's Eating Behavior, and Weight Status among Children of Preschool Age in China
Authors: Yuan Jing , Jiang Xun , Zhu Tongyu , Zhang Yuhai , Wang Yue , Yang Xianjun , Shang Lei 
Published: August 2020

Abstract
Background Childhood overweight and obesity have become significant public health challenges worldwide. This study aimed to explore whether caregivers’ feeding behavior and children’s eating behavior were associated with the weight status of preschool children in China.Methods A cross-sectional questionnaire was administered to 912 caregivers of preschool children from April to July 2016. Caregivers’ feeding behaviors were assessed by the Chinese Preschooler’s Caregiver Feeding Behavior Scale (CPCFBS). Children’s eating behaviors were evaluated using the Chinese Preschooler’s Eating Behavior Questionnaire (CPEBQ). After controlling for demographic characteristics, multiple linear regression and logistic regression analyses were performed to evaluate the relationship between caregivers’ feeding behavior, children's eating behavior, and children's body mass index (BMI). Results The results showed that weight concerns on the part of caregivers (β=0.53) and food responsiveness on the part of children (β=0.93) were positively correlated with children’s BMI, whereas caregivers’ responsibility for feeding (β=-0.68) and children’s external eating (β=-0.53) were negatively correlated with BMI. Among caregiver feeding behaviors, weight concerns (OR=4.54, P<0.001) and behavior-restricted feeding (OR=0.29, P<0.001) were positively correlated with children’s BMI. A child’s food responsiveness (OR=4.04, P<0.001) was also positively correlated with his/her BMI, while the child’s satiety responsiveness (OR=0.42, P<0.001) and emotional eating habits (OR=0.56, P<0.001) were negatively correlated with overweight/obesity status. Conclusions Our study demonstrated that children’s eating behavior and caregivers’ feeding behavior were associated with weight status among preschool children in China. Behavior interventions on caregivers as well as their children may prevent or reduce weight problems in preschool children. Trial registration This study was not a clinical experiment.
Clinicopathological Characteristics and Survival Outcomes for Pneumonectomy: a Population-Based Study
Authors: Wang Linlin , Ge Lihui , Liu Yongyu , Ren Yi 
Published: August 2020

Abstract
Background: Prognostic factors in pneumonectomy (PN) are not yet fully defined. This study is to analyze and evaluate long-term survival after PN for non-small cell lung cancer (NSCLC). Methods: We obtained data from the Surveillance, Epidemiology, and End Results (SEER) database for patients who underwent PN between 2004 and 2015. In order to reduce bias and imbalance, propensity score matching (PSM) analysis was performed. We used Kaplan-Meier curves to estimate overall survival (OS), performed univariate and multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for OS, and applied the Cox proportional hazards model to create a forest plot. Results: A total of 1557 PN patients from the SEER database were included. The patients were grouped according to the side of PN. Before matching, OS was worse after right PN (hazard ratio [HR]: 1.303; 95% confidence interval [CI] 1.133-1.498; P<0.001), but survival difference between groups was not significant after matching (HR: 1.061; 95% CI 0.912-1.235; P=0.443). Regression analysis revealed that age, grade, N-stage, radiotherapy, and chemotherapy were independent predictors of OS (P<0.05). Chemotherapy was associated with improved OS (HR: 0.709; 95% CI 0.609-0.825; P<0.001), but radiotherapy was associated with increased risk of death in OS (HR: 1.268; 95% CI 1.061-1.561; P=0.009). On the forest plot, patients with primary overlapping lesions had better OS (HR: 0.684; 95% CI 0.497-0.941; P=0.020) in left, vs right, PN; patients diagnosis during 2004 to 2007 had lower OS (HR: 0.576; 95% CI 0.346-0.960; P=0.034) for left PN vs right PN.Conclusions: Laterality was not a significant prognostic factor for long-term survival after PN for NSCLC. Chemotherapy was a significant independent predictor of improved OS, while radiotherapy appeared to be a negative prognostic factor with increased risk of death in OS.
Recurrence of Overdose Suicide Attempt Index: A Novel Scoring System for Predicting the Recurrence of Intentional Overdose
Authors: Hirose Masayuki , Kasugai Daisuke , Tajima Kousuke , Takahashi Hiroshi , Yamada Shigeki , Hirakawa Akihiko 
Published: August 2020

Abstract
Aim: Repeated suicide attempts through intentional overdose are not infrequent, but little is known about the risk factors for intentional overdose. We aimed to investigate risk factors for the recurrence of intentional overdose within 1 year of discharge and to develop an index that predicts recurrence.Methods: This retrospective observational study included 419 patients admitted to our hospital between 2011 and 2018 because of an intentional overdose. Of them, 43 (10.0%) repeated an overdose within 1 year of discharge. The risk factors with the highest odds ratios in multivariate logistic regression analysis were used to develop an index Recurrence of Overdose Suicide Attempt. The predictive value of this index for recurrence was compared with that of the existing SAD PERSONS scale.Results: The following variables were significantly associated with recurrence and were included in the index: anxiety and/or insomnia at discharge; use of five or more psychotropic drugs; a neurotic, stress-related, or somatoform disorder; and female sex (odds ratios: 4.24; 5.52; 2.41; and 3.41, respectively). The newly developed index was a significantly better predictor of recurrence than the SAD PERSONS scale (area under the receiver operating characteristics curve, 0.797 vs. 0.668; p = 0.007). Sensitivity, specificity, and positive and negative predictive values for Recurrence of Overdose Suicide Attempt > 4 points (out of 6) were 72.1%, 75.8%, 25.4%, and 96.0%, respectively.Conclusion: The novel index can predict the recurrence of intentional overdose with a good negative predictive value and may therefore be a useful screening tool for this high-risk population.
Sleep Disturbance Severity is Associated With Cognitive Impairment in Patients With First-episode, Treatment-naïve Major Depressive Disorders
Authors: Cui Feihuan , Liu Qi , Lv Xiaozhen , Leonhart Rainer , Tian Hongjun , Wei Jing , Zhang Kerang , Zhu Gang , Chen Qiaoling , Wang Gang , Wang Xueyi , Zhang Nan , Huang Yu , Si Tianmei , Yu Xin 
Published: August 2020

Abstract
BackgroundSleep disorders and cognitive impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in first-episode, treatment-naïve patients with MDD.MethodWe analyzed data from 242 patients withMDD. We divided the patients into 2 groups based on sleep disturbance severity and compared the cognitive impairment odds ratios in different domains between the groups.ResultsA total of 121 pairs of patients were matched (age39.4±10.1, 70.2% female). After propensity score matching, the odds ratios for cognitive impairment in patients with MDD and serious sleep disorders were 1.922 (1.068–3.459, P= 0.029) in executive functioning; 2.023 (1.211–3.379, P= 0.007) in executive shifting; 1.749 (1.000–3.060, P = 0.050) in executive inhibition; and 1.813 (1.038–3.167, P = 0.037) in information processing speed.LimitationsThe cross-sectional data on the relationship between sleep disorders and cognitive impairment were weak. Our study population was restricted to Chinese adults aged 18 to 65 years, so the results may not be generalizable to other populations.Because our sample size was limited, some variables were not included in the study.ConclusionsSleep disturbance is associated with cognitive impairment in the domains of executive functioning and information processing speed in first-episode, treatment-naïve patients with MDD. Sleep problems can be important symptoms for physicians in clinical practice and can aid in recognizing cognitive impairment in patients with MDD. Further study is required to confirm our results.Trial registrationClinicalTrials.gov: NCT02023567; registration date: December 2013.
Visible-Light Photoredox-Catalyzed C–O Bond Cleavage of Diaryl Ethers by Acridinium Photocatalysts at Room Temperature
Authors: Tan Fang-Fang , He Xiao-Ya He , Tian Wan-Fa , Li Yang 
Published: August 2020

Abstract
We have developed visible-light photoredox-catalyzed C–O bond cleavage of diaryl ethers by an acidolysis with an aryl car-boxylic acid and a following one-pot hydrolysis. Two phenols are obtained from a diaryl ether at room temperature. The aryl carboxylic acid used for the acidolysis can be recovered. The key to success of the acidolysis is merging visible-light photore-dox catalysis with a new acridinium photocatalyst and Lewic acid catalysis with Cu(TMHD)2. Preliminary mechanistic studies indicate that the catalytic cycle occurs via a rare selective electrophilic attack of the generated aryl carboxylic radical on the electron-rich aryl ring of diphenyl ether. This transformation is applied to a gram-scale reaction and the model of 4-O-5 lignin linkages.
In Vitro Cell Responses of MG-63 Osteoblast Cells on Bioactive Diopside and Wollastonite Nano-Bioceramics for Biomedical Applications
Authors: Foroushani Ruhollah Zamani , Karamian Ebrahim , Rafienia Mohammad 
Published: August 2020

Abstract
The present study aimed to synthesize and characterize diopside (CaMgSi2O6) and wollastonite (CaSiO3) nano-bioceramics via a combination of mechano-chemical and calcination processes. In vitro biomineralization and cell responses of wollastonite and diopside were performed on simulated body fluid (SBF) and MG-63 osteoblast cells. Results revealed proper tissue biomineralization of wollastonite and diopside through the generation of an apatite-like layer on the surface of nano-bioceramics. Cell responses of wollastonite and diopside eventuated non-cytotoxicity by MG-63 osteoblast cells, and their viability and cell proliferation were confirmed. Alizarin red staining of diopside and wollastonite evidenced great bioactivity and tissue biomineralization, and the ALP enzyme of diopside and wollastonite was enhanced in contact with the MG-63 osteoblast cells. Regarding the existence of Mg2+ in the calcium-silicate network and the stability network, diopside illustrated high biological and cell responses in comparison to wollastonite, and both of them were suggested as bioactive and biocompatible nano-bioceramics for biomedical applications.
Fat and Carbohydrate Distribution in Maternal Diet Programs Liver SIRT1 Expression and Fatty Acid Profile in Offspring
Authors: Mousavi Seyedeh Neda , Dorraji Mir Saeed Seyed , Gharacheh Sara , Koohdani Fariba 
Published: August 2020

Abstract
Background: Amount of fat and carbohydrate in maternal diet during gestation and lactation has permanent effects on fetal metabolism. SIRT1 is a nutrient-responsive histone deacetylase that modulates the lipid and glucose metabolism in response to energy stress and extends life span. Herein, we assessed the effects of carbohydrate and fat distribution in a maternal isocaloric diet on fetal gene and protein levels of SIRT1, as well as liver fatty acid profile. Twenty C57BL/6 female mice were inseminated and randomly received the AIN 93G isocaloric pair-fed LF-HC (16% and 64% of calorie as fat and carbohydrate) or HF-LC (48% and 32% of calorie as fat and carbohydrate) diet during gestation and lactation. After weaning, all offspring received LF-HC diet up to the adolescence. Liver tissue were extracted for final analysis. Results: SIRT1 gene and protein levels were lower in both sexes born from HF-LC-fed mothers than LF-HC-fed one, significant differences were only observed between males in the gene expression (p<0.001) and females in protein level (p<0.001). Saturated fatty acids and cholesterol were increased while unsaturated fatty acids decreased at the liver of male and female offspring born from HF-LC-fed mothers (p<0.001). Conclusions: Maternal dietary fat and carbohydrate distribution, regardless of calorie intake, modify the offspring hepatic fatty acid profile, as well as SIRT1 gene and protein expression which effects on life span.
Thymoquinone and Costunolide Induce Extensive Apoptosis of Senescent Colon and Senescent Breast Cancer Cells
Authors: El-Far Ali H , Noreldin Ahmed E. , Jaouni Soad K. Al , Mousa Shaker A. 
Published: August 2020

Abstract
Several chemotherapeutic agents induce cancer cells’ senescence as monitored by enlargement of cell, cell cycle arrest, elevated activities of senescence-associated β-galactosidase (SA-β-gal), and upregulation of p53 and p21. Doxorubicin (Dox) is an anticancer chemotherapeutic drug, classified as an anthracycline antibiotic, that induces senescence of numerous cancer cell types. The arrest of cancer cell growth is a bright face of senescence, while these senescent cancer cells relapse again if they are not eliminated. On this principle, we investigated the apoptotic effect of thymoquinone (TQ), the active ingredient of Nigella sativa seeds and costunolide (COS), the active ingredient of Costus speciosus, on senescent colon (Sen-HCT116) and senescent breast (Sen-MCF7) cancer cell lines in reference to their corresponding proliferative cells to rapidly eliminate the senescent cancer cells. The senescence markers of Sen-HCT116 and Sen-MCF7 were determined by significant decrease in bromodeoxyuridine (BrdU) incorporation and significant increases in SA-β-gal, p53, and p21 levels. After proliferative, Sen-HCT116, and Sen-MCF7 cells were subjected to either TQ (50 µM) or COS (30 µM), the Bcl2-associated X protein (Bax), B-cell lymphoma 2 (Bcl2), and their ratio were established. Results revealed that TQ significantly increased the Bax/Bcl2 ratio in HCT116+Dox5+TQ, MCF7+TQ, and MCF7+Dox5+TQ compared with their corresponding controls. COS significantly increased the Bax/Bcl2 ratio in HCT116+Dox5+TQ and MCF7+Dox5+TQ compared with their corresponding controls. The data revealed more sensitivity of senescent cells to TQ or COS than their corresponding proliferative cells. Thus, we may be able to use TQ or COS to rapidly eliminate senescent cancer cells following Dox treatment; these results need to be confirmed with in vivo and clinical trials.
The Effect of Using the Minimized Cardio-pulmonary Bypass Systems for Coronary Artery Bypass Grafting in Diabetic Patients
Authors: Albacker Turki , Fouda Mohammed , Bakir Bakir M. , Eldemerdash Ahmed 
Published: August 2020

Abstract
Introduction
Multiple studies have shown a decrease in the inflammatory response with minimized bypass circuits leading to less complications and mortality rate. On the other hand, some other studies showed that there is no difference in post-operative outcomes. So, the aim of this study is to investigate the clinical benefits of using the Minimized cardiopulmonary Bypass system in Coronary Artery Bypass Grafting and its effect on postoperative morbidity and mortality in diabetic patients as one of the high-risk groups that may benefit from these systems.
Methods:
This is a retrospective study that included 114 diabetic patients who underwent Coronary artery bypass grafting (67 patients with conventional cardiopulmonary bypass system and 47 with Minimized cardiopulmonary bypass system). The patients’ demographics, intra-operative characteristics and postoperative complications were compared between the two groups.
Results
Coronary artery bypass grafting was done on a beating heart less commonly in the conventional cardiopulmonary bypass group (44.78% vs. 63.83%, p = 0.045). There was no difference between the two groups in blood loss or transfusion requirements. Four patients in the conventional cardiopulmonary bypass group suffered perioperative myocardial infarction while no one had perioperative myocardial infarction in the Minimized cardiopulmonary bypass group. On the other hand, less patients in the conventional group had postoperative Atrial Fibrillation (4.55% vs. 27.5%, p = 0.001). The requirements for Adrenaline and Nor-Adrenaline infusions were more common the conventional group than the Minimized group.
Conclusion
The use of conventional cardiopulmonary bypass for Coronary Artery Bypass Grafting in diabetic patients was associated with higher use of postoperative vasogenic and inotropic support. However, that did not translate into higher complications rate or mortality.
Ketogenic Diet-mediated Steroid Metabolism Reprogramming Improves the Immune Microenvironment and Myelin Growth of Spinal Cord Injury Rats Through Gene Analysis and Co-expression Network Analysis
Authors: Zeng Hong , Lu Yao , Huang Meng jie , Liu Nan , Yang Yan yan , Xing Hua yi , Liu Xiao xie , Zhou Mouwang 
Published: August 2020

Abstract
BackgroundThe ketogenic diet has been widely used in the treatment of various nervous system and metabolic-related diseases. Our previous research found that a ketogenic diet exerts a protective effect and promotes functional recovery after spinal cord injury. However, the mechanism of treatment is still unclear. In this study, different dietary feeding methods were used to detect myelin expression and gene level changes between different groups.ResultFirst, KEGG pathway enrichment of upregulated differentially expressed genes (DEGs) in the SCI_KD and SCI_SD groups and GSEA analysis of the two groups found that a ketogenic diet significantly improved the steroid anabolic pathway in rats with spinal cord injury. Through cluster analysis, PPI analysis and visualization of iPath metabolic pathways, Sqle, Sc5d, Cyp51, Dhcr24, Msmo1, Hsd17b7, and Fdft1 changed significantly in the pathway. Second, through WGCNA analysis, all samples are placed in a gene network to analyse the correlation between gene modules and phenotypes. After module analysis, GO function and KEGG analysis showed that rats fed a ketogenic diet showed significantly reduced immune-related pathways, including those associated with immune and infectious diseases.ConclusionA ketogenic diet may improve the immune microenvironment and myelin growth in rats with spinal cord injury through reprogramming of steroid metabolism.
Feasibility Study on Use of Near Infrared Spectroscopy for Rapid and Non-Destructive Determination of Gossypol Content in Intact Cottonseeds
Authors: Li Cheng , Su Bangsong , Zhao Tianlun , Li Cong , Chen Jinhong , Zhu Shuijin 
Published: August 2020

Abstract
Background

Gossypol found in cottonseeds is toxic to human beings and monogastric animals and is a primary parameter for integrated utilization of cottonseed products. It is usually determined by the techniques relied on complex pretreatment procedures and the samples after determination cannot be used in breeding program, so it is of great importance to predict the gossypol content in cottonseeds rapidly and non-destructively to substitute the traditional analytical method.
Results

Gossypol content in cottonseeds was investigated by near-infrared spectroscopy (NIRS) and High-performance liquid chromatography (HPLC). Partial least squares regression, combined with spectral pretreatment methods including Savitzky-Golay smoothing, standard normal variate, multiplicative scatter correction, and first derivate, were tested for optimizing the calibration models. NIRS technique was efficient in predicting gossypol content in intact cottonseeds, as revealed by the root-mean-square error of cross-validation (RMSECV), root-mean-square error of prediction (RMSEP), coefficient for determination of prediction (Rp2), and residual predictive deviation (RPD) values for all models, being 0.05–0.07, 0.04–0.06, 0.82–0.92, and 2.3–3.4, respectively. The optimized model pretreated by Savitzky-Golay smoothing + standard normal variate + first derivate resulted in good determination of gossypol content in intact cottonseeds.
Conclusions

Near infrared spectroscopy coupled with different spectral pretreatments and PLS regression has exhibited the feasibility in predicting gossypol content in intact cottonseeds, rapidly and non-destructively. It could be used as an alternative method to substitute for traditional one to determine the gossypol content in intact cottonseeds.
WITHDRAWN: Temperature-Dependent Ferroelectric and Piezoelectric Response of Yb3+ and Tm3+ co-Doped Ba0.95Ca0.05Ti0.90Zr0.10O3 Lead-Free Ceramic
Authors: Tian Yongshang , Wang Qiqi , Zhang Bingqian , Qin Panpan , Gong Yansheng , Ji Xiang , Jing Qiangshan 
Published: August 2020

Abstract
The electrical properties of piezoelectric ceramics are temperature-dependent, which affects their potential for applications in environments with temperature variation. In this work, a Yb3+ and Tm3+ co-doped Ba0.95Ca0.05Ti0.90Zr0.10O3 (BCTZ-YT) dense lead-free ceramic was prepared using a modified polymeric precursor route. The structural characteristics were investigated by X-ray diffraction, scanning electron microscopy, and Raman spectroscopy. The temperature-dependence of the ferroelectricity, piezoelectricity, and permittivity was studied in detail. On the basis of structural and electrical measurements at various temperatures, the mechanism of a lack of oxygen vacancies, small structural defects, and small defect dipoles was deduced. This study reveals that the ferroelectricity and piezoelectricity are temperature-dependent, whereas the capacitance is essentially unchanged with increasing temperature owing to the presence of a pure orthorhombic phase. The results of this study are expected to inform future research.
Weighted gene co-expression network analysis to identify key modules and hub genes related to hyperlipidaemia
Authors: Liao Fu Jun , Zheng Peng-Fei , Guan Yao-Zong , Li Wei 
Published: August 2020

Abstract
Background: The purpose of this study was to explore the potential molecular targets of hyperlipidaemia and the related molecular mechanisms.Methods: The microarray data set of GSE66676 obtained from patients with hyperlipidaemia was downloaded. The weighted gene co‑expression network (WGCNA) analysis was used to analyze the gene expression profile and royalblue module was considered as the highest correlation. Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and genomes (KEGG) pathway enrichment analyses were implemented for the identification of genes in the royalblue module using the Database for Annotation, Visualization and Integrated Discovery (DAVID) online tool (version 6.8; http://david.abcc.ncifcrf.gov). A protein-protein interaction (PPI) network was established by using the online STRING tool. Then, several hub genes were identified by the MCODE and cytoHubba plug-ins in Cytoscape software.Results: The significant module (royalblue) identified was associated with TC, TG and Non-HDL-C. GO and KEGG enrichment analyses revealed that the genes in the royalblue module were associated with carbon metabolism, steroid biosynthesis, fatty acid metabolism and biosynthesis of unsaturated fatty acids pathways. SQLE (degree = 17) was revealed as key molecules that associated with hypercholesterolemia (HCH) and SCD was revealed as key molecules that associated with hypertriglyceridemia (HTG). Meanwhile, RT-qPCR analysis also confirmed the above results based on our HCH/HTG samples.Conclusions: SQLE and SCD are related to hyperlipidaemia, SQLE/SCD may be new targets for cholesterol-lowering or triglyceride-lowering therapy, respectively.