bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythema Multiforme Versus Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: Subtle Difference in Presentation, Major Difference in Management
Authors: Newkirk Russell E , Fomin Daren A , Braden Mary M 
Published: May 2020

AbstractErythema multiforme and Stevens–Johnson syndrome/toxic epidermal necrolysis are immune-mediated epidermal conditions with variable clinical presentations. Although their clinical presentations often overlap, they have distinct etiologies and potential outcomes, which necessitate specific management strategies. This case is presented to highlight the subtle differences and review management given that Stevens–Johnson syndrome/toxic epidermal necrolysis can rapidly become life-threatening. The need for astute diagnostic work-up and accuracy is magnified in the military setting given operations in austere environments and availability of medical and medical evacuation resources. Herein, we present a less common case of bullous erythema-multiforme, the diagnostic approach, and clinical differential with special attention to the importance of the military physician.
A long-period (P = 61.8 d) M5V dwarf eclipsing a Sun-like star from TESS and NGTS
Authors: Gill Samuel , Cooke Benjamin F , Bayliss Daniel , Nielsen Louise D , Lendl Monika , Wheatley Peter J , Anderson David R , Moyano Maximiliano , Bryant Edward M , Acton Jack S , Belardi Claudia , Bouchy François , Burleigh Matthew R , Casewell Sarah L , Chaushev Alexander , Goad Michael R , Jackman James A G , Jenkins James S , McCormac James , Günther Maximilian N , Osborn Hugh P , Pollacco Don , Raynard Liam , Smith Alexis M S , Tilbrook Rosanna H , Turner Oliver , Udry Stéphane , Vines Jose I , Watson Christopher A , West Richard G 
Published: May 2020

ABSTRACT
The Transiting Exoplanet Survey Satellite has produced a large number of single-transit event candidates which are being monitored by the Next Generation Transit Survey (NGTS). We observed a second epoch for the TIC-231005575 system (Tmag = 12.06 and $T_{\rm eff} = 5500 \pm 85\, \mathrm{ K}$) with NGTS and a third epoch with Las Cumbres Observatory’s telescope in South Africa to constrain the orbital period ($P = 61.777\, \mathrm{ d}$). Subsequent radial velocity measurements with CORALIE revealed the transiting object has a mass of M2 = 0.128 ± 0.003 M⊙, indicating the system is a G-M binary. The radius of the secondary is R2 = 0.154 ± 0.008 R⊙ and is consistent with mesa models of stellar evolution to better than 1σ.
Timing of the accreting millisecond pulsar IGR J17591–2342: evidence of spin-down during accretion
Authors: Sanna A , Burderi L , Gendreau K C , Di Salvo T , Ray P S , Riggio A , Gambino A F , Iaria R , Piga L , Malacaria C , Jaisawal G K 
Published: May 2020

ABSTRACT
We report on the phase-coherent timing analysis of the accreting millisecond X-ray pulsar IGR J17591–2342, using Neutron Star Interior Composition Explorer (NICER) data taken during the outburst of the source between 2018 August 15 and 2018 October 17. We obtain an updated orbital solution of the binary system. We investigate the evolution of the neutron star spin frequency during the outburst, reporting a refined estimate of the spin frequency and the first estimate of the spin frequency derivative ($\dot{\nu }\sim -7\times 10^{-14}$ Hz s−1), confirmed independently from the modelling of the fundamental frequency and its first harmonic. We further investigate the evolution of the X-ray pulse phases adopting a physical model that accounts for the accretion material torque as well as the magnetic threading of the accretion disc in regions where the Keplerian velocity is slower than the magnetosphere velocity. From this analysis we estimate the neutron star magnetic field Beq = 2.8(3) × 108 G. Finally, we investigate the pulse profile dependence on energy finding that the observed behaviour of the pulse fractional amplitude and lags as a function of energy is compatible with the down-scattering of hard X-ray photons in the disc or the neutron star surface.
Common envelope evolution on the asymptotic giant branch: unbinding within a decade?
Authors: Chamandy Luke , Blackman Eric G , Frank Adam , Carroll-Nellenback Jonathan , Tu Yisheng 
Published: May 2020

ABSTRACT
Common envelope (CE) evolution is a critical but still poorly understood progenitor phase of many high-energy astrophysical phenomena. Although 3D global hydrodynamic CE simulations have become more common in recent years, those involving an asymptotic giant branch (AGB) primary are scarce, due to the high computational cost from the larger dynamical range compared to red giant branch (RGB) primaries. But CE evolution with AGB progenitors is desirable to simulate because such events are the likely progenitors of most bi-polar planetary nebulae (PNe), and prominent observational testing grounds for CE physics. Here we present a high-resolution global simulation of CE evolution involving an AGB primary and 1-$\mathrm{M_\odot }$ secondary, evolved for 20 orbital revolutions. During the last 16 of these orbits, the envelope unbinds at an almost constant rate of about 0.1–$0.2\, \mathrm{M_\odot \, yr^{-1}}$. If this rate were maintained, the envelope would be unbound in less than $10\, {\rm yr}$. The dominant source of this unbinding is consistent with inspiral; we assess the influence of the ambient medium to be subdominant. We compare this run with a previous run that used an RGB phase primary evolved from the same 2-$\mathrm{M_\odot }$ main-sequence star to assess the influence of the evolutionary state of the primary. When scaled appropriately, the two runs are quite similar, but with some important differences.
Exploring chemical homogeneity in dwarf galaxies: a VLT-MUSE study of JKB 18
Authors: James Bethan L , Kumari Nimisha , Emerick Andrew , Koposov Sergey E , McQuinn Kristen B W , Stark Daniel P , Belokurov Vasily , Maiolino Roberto 
Published: May 2020

ABSTRACT
Deciphering the distribution of metals throughout galaxies is fundamental in our understanding of galaxy evolution. Nearby, low-metallicity, star-forming dwarf galaxies, in particular, can offer detailed insight into the metal-dependent processes that may have occurred within galaxies in the early Universe. Here, we present VLT/MUSE observations of one such system, JKB 18, a blue diffuse dwarf galaxy with a metallicity of only 12 + log(O/H)=7.6 ± 0.2 (∼0.08 Z⊙). Using high spatial resolution integral-field spectroscopy of the entire system, we calculate chemical abundances for individual H ii regions using the direct method and derive oxygen abundance maps using strong-line metallicity diagnostics. With large-scale dispersions in O/H, N/H, and N/O of ∼0.5–0.6 dex and regions harbouring chemical abundances outside this 1σ distribution, we deem JKB 18 to be chemically inhomogeneous. We explore this finding in the context of other chemically inhomogeneous dwarf galaxies and conclude that neither the accretion of metal-poor gas, short mixing time-scales or self-enrichment from Wolf–Rayet stars are accountable. Using a galaxy-scale, multiphase, hydrodynamical simulation of a low-mass dwarf galaxy, we find that chemical inhomogeneities of this level may be attributable to the removal of gas via supernovae and the specific timing of the observations with respect to star formation activity. This study not only draws attention to the fact that dwarf galaxies can be chemically inhomogeneous, but also that the methods used in the assessment of this characteristic can be subject to bias.
Biosignature surveys to exoplanet yields and beyond
Authors: Sandora McCullen , Silk Joseph 
Published: May 2020

ABSTRACT
Upcoming biosignature searches focus on indirect indicators to infer the presence of life on other worlds. Aside from just signalling the presence of life, however, some biosignatures can contain information about the state that a planet’s biosphere has achieved. This additional information can be used to measure what fractions of planets achieve certain key stages, corresponding to the advent of life, photosynthesis, multicellularity, and technological civilization. We forecast the uncertainties of each measurement for upcoming surveys, and outline the key factors that determine these uncertainties. Our approach is probabilistic and relies on large numbers of candidates rather than detailed examination of individual exoplanet spectra. The dependence on survey size, likeliness of the transition, and several measures of degrees of confidence are discussed, including discussion of geological false positives in biosignatures as well as how combining data from different missions can affect the inference. Our analysis should influence policy recommendations for future mission design and strategy to minimize the impact of measurement uncertainties.
MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis
Authors: Shang Yongliang , Huang Tao , Liu Hongbin , Liu Yanlei , Liang Heng , Yu Xiaoxia , Li Mengjing , Zhai Binyuan , Yang Xiao , Wei Yudong , Wang Guoqiang , Chen Zijiang , Wang Shunxin , Zhang Liangran 
Published: May 2020

AbstractRepair of DNA double-strand breaks (DSBs) with homologous chromosomes is a hallmark of meiosis that is mediated by recombination ‘bridges’ between homolog axes. This process requires cooperation of DMC1 and RAD51 to promote homology search and strand exchange. The mechanism(s) regulating DMC1/RAD51-ssDNA nucleoprotein filament and the components of ‘bridges’ remain to be investigated. Here we show that MEIOK21 is a newly identified component of meiotic recombination bridges and is required for efficient formation of DMC1/RAD51 foci. MEIOK21 dynamically localizes on chromosomes from on-axis foci to ‘hanging foci’, then to ‘bridges’, and finally to ‘fused foci’ between homolog axes. Its chromosome localization depends on DSBs. Knockout of Meiok21 decreases the numbers of HSF2BP and DMC1/RAD51 foci, disrupting DSB repair, synapsis and crossover recombination and finally causing male infertility. Therefore, MEIOK21 is a novel recombination factor and probably mediates DMC1/RAD51 recruitment to ssDNA or their stability on chromosomes through physical interaction with HSF2BP.
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
Authors: Humphrey Jack , Birsa Nicol , Milioto Carmelo , McLaughlin Martha , Ule Agnieszka M , Robaldo David , Eberle Andrea B , Kräuchi Rahel , Bentham Matthew , Brown Anna-Leigh , Jarvis Seth , Bodo Cristian , Garone Maria G , Devoy Anny , Soraru Gianni , Rosa Alessandro , Bozzoni Irene , Fisher Elizabeth M C , Mühlemann Oliver , Schiavo Giampietro , Ruepp Marc-David , Isaacs Adrian M , Plagnol Vincent , Fratta Pietro 
Published: May 2020

AbstractMutations in the RNA-binding protein FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease. FUS plays a role in numerous aspects of RNA metabolism, including mRNA splicing. However, the impact of ALS-causative mutations on splicing has not been fully characterized, as most disease models have been based on overexpressing mutant FUS, which will alter RNA processing due to FUS autoregulation. We and others have recently created knockin models that overcome the overexpression problem, and have generated high depth RNA-sequencing on FUS mutants in parallel to FUS knockout, allowing us to compare mutation-induced changes to genuine loss of function. We find that FUS-ALS mutations induce a widespread loss of function on expression and splicing. Specifically, we find that mutant FUS directly alters intron retention levels in RNA-binding proteins. Moreover, we identify an intron retention event in FUS itself that is associated with its autoregulation. Altered FUS levels have been linked to disease, and we show here that this novel autoregulation mechanism is altered by FUS mutations. Crucially, we also observe this phenomenon in other genetic forms of ALS, including those caused by TDP-43, VCP and SOD1 mutations, supporting the concept that multiple ALS genes interact in a regulatory network.
Smoking Is Associated With COVID-19 Progression: A Meta-analysis
Authors: Patanavanich Roengrudee , Glantz Stanton A 
Published: May 2020

Abstract

Introduction
Smoking depresses pulmonary immune function and is a risk factor contracting other infectious diseases and more serious outcomes among people who become infected. This paper presents a meta-analysis of the association between smoking and progression of the infectious disease COVID-19.

Methods
PubMed was searched on April 28, 2020, with search terms “smoking”, “smoker*”, “characteristics”, “risk factors”, “outcomes”, and “COVID-19”, “COVID”, “coronavirus”, “sar cov-2”, “sar cov 2”. Studies reporting smoking behavior of COVID-19 patients and progression of disease were selected for the final analysis. The study outcome was progression of COVID-19 among people who already had the disease. A random effects meta-analysis was applied.

Results
We identified 19 peer-reviewed papers with a total of 11,590 COVID-19 patients, 2,133 (18.4%) with severe disease and 731 (6.3%) with a history of smoking. A total of 218 patients with a history of smoking (29.8%) experienced disease progression, compared with 17.6% of non-smoking patients. The meta-analysis showed a significant association between smoking and progression of COVID-19 (OR 1.91, 95% confidence interval [CI] 1.42-2.59, p = 0.001). Limitations in the 19 papers suggest that the actual risk of smoking may be higher.

Conclusions
Smoking is a risk factor for progression of COVID-19, with smokers having higher odds of COVID-19 progression than never smokers.

Implications
Physicians and public health professionals should collect data on smoking as part of clinical management and add smoking cessation to the list of practices to blunt the COVID-19 pandemic.
Partial Melts of Intermediate–Felsic Sources in a Wedged Thickened Crust: Insights from Granites in the Sulu Orogen
Authors: Wu Hongjie , He Yongsheng , Li Shuguang , Zhu Chuanwei , Hou Zhenhui 
Published: May 2020

Abstract
High-pressure (&gt;15 kbar) melts of intermediate–felsic materials have been well studied by experiments, whereas their existence in nature, especially in orogenic belts, is rarely examined. With the aim of identifying and characterizing high-pressure partial melts of intermediate–felsic continental crusts, this study presents comprehensive geochemical and geochronological data for 47 Jurassic granites (166∼157 Ma) from the Sulu orogen. These Sulu Jurassic granites (SJG) consist of quartz, K-feldspar and plagioclase with minor mineral assemblages of biotite ± muscovite ± garnet ± epidote ± allanite. Their low mafic mineral abundance, high SiO2 and Al2O3, and low FeOt + MgO contents show leucogranite-like affinities. They have low Mg#, low Rb/Sr, and mildly peraluminous features, collectively suggesting an intermediate–felsic orthogneissic source. Whole-rock Zr saturation thermometry and Ti-in-zircon thermometry together suggest initial magma temperatures between 695 ± 32 °C and 751 ± 27 °C (1 standard deviation), indicating derivation from water-present melting. The SJG notably feature high Sr contents (average 792 ppm), high Sr/CaO ratios (average 476) as well as inter-correlated low REE concentrations (average ΣREE 87 ppm), low Th concentrations (average 5·1 ppm) and positive Eu anomalies (Eu/Eu* up to 2·94). These characteristics are best explained by partial melting of intermediate–felsic sources under high pressure (&gt;15 kbar), leaving residuum where feldspar is sparse or absent and allanite is present. Inherited zircon age spectra and Sr–Nd–Pb isotopic compositions suggest that their source components could be mainly the Triassic orthogneisses whose protoliths are from the northern margin of the South China Block, probably in a wedge structure where the exhumed felsic slabs were wedged into the crust of the North China Block in the middle–late Jurassic and formed a stacked thickened crust. The wedge structure was most probably driven by synchronous large-scale strike-slip of the Tanlu fault, as a far-field effect of the oblique subduction of the paleo-Pacific plate. The characteristic chemical features observed in this study may be applied to identifying partial melts with similar petrogenesis elsewhere.
Factors Impacting Physical Therapy Utilization for Patients With Nonspecific Low Back Pain: Retrospective Analysis of a Clinical Data Set
Authors: Dolot Janet , Hyland Matthew , Shi Qiuhu , Kim Hae-Young , Viola Deborah , Hoekstra Christopher 
Published: May 2020

AbstractObjectiveFactors predicting physical therapy utilization for lower back pain (LBP) remain unclear, limiting the development of value-based initiatives. The purpose of this study was to identify important factors that impact the number of physical therapist visits per episode of care for US adults with nonspecific LBP.MethodsThis study was a retrospective observational cohort study of a clinical dataset derived from 80 clinics of a single physical therapy provider organization. Research variables were categorized at the individual (patient) level and the organization (therapist, clinic) level. A hierarchical regression model was designed to identify factors influencing the number of physical therapist visits per episode of care.ResultsHigher out-of-pocket payments per visit, receipt of “active” physical therapy, longer average visit length, earlier use of physical therapy, and sex of the therapist (male) were found to predict fewer visits per episode of care. Percent change of function, prior receipt of physical therapy by the same provider organization, self-discharge from physical therapy, level of starting function, and therapist certification were found to predict more visits. Of the variance in number of visits, 8.0% was attributable to the health care organization.ConclusionsIndividual factors, such as higher out-of-pocket payment, have a significant impact on reducing visits per episode of care and should be considered when developing value-based initiatives to optimize clinical and utilization outcomes.ImpactPayers use consumer-directed healthcare to reduce costs by discouraging utilization of low value services and encouraging use of low-cost providers. LBP is a costly condition for which physical therapy is a high-value treatment. This study shows that non-need factors predict the number of physical therapy visits per episode of care for patients with nonspecific LBP. Insurance benefit plans with lower out-of-pocket payments for physical therapy and higher reimbursement for active physical therapist interventions may facilitate appropriate utilization of high-value treatment for LBP.
Congenital heart disease in adults (when kids grow up) pediatric geriatric anesthesia
Authors: Motta Pablo , Manrique Ana M. , Partington Sara L. , Ullah Sana , Zabala Luis M. 
Published: May 2020

Purpose of review
The current review focuses on the new development of adult congenital heart disease (ACHD) patients in the areas of imaging, percutaneous interventions, ventricular assist devices and transplantation.

Recent findings
Since the last ACHD publication in the journal, several advances have been made in the evaluation and treatment of these patients. As CHD patients’ longevity increases pregnancy, comorbities and acquired heart disease become a concern. Recent data show that the incidence of complications in low-risk CHD is not higher that the regular population. In addition, breakthrough research in percutaneous valve implantation has been published showing good outcomes but needing intensive care recovery in a significant number of patients. In the ACHD heart failure population, assist device and transplant fields mounting evidence shows that these therapies should not be the last resort since low-risk ACHD patient may have similar outcomes to those with acquired heart disease. Finally risk stratification is important in ACHD to define better ways to recover from surgery and anesthesia.

Summary
The field of anesthesia for ACHD is growing with new indications for diagnostic, interventional and surgical procedures. Tailoring cardiac and noncardiac care to the different risk profile in ACHD patients will be defined in the next few years.

Video abstract
Motta summary clip: http://links.lww.com/COAN/A65.
Prehabilitation: the anesthesiologist's role and what is the evidence?
Authors: Minnella Enrico Maria , Coca-Martinez Miquel , Carli Francesco 
Published: May 2020

Purpose of review
Surgery poses major threats to functional independence. Prehabilitation is a preoperative conditioning intervention that aims to prevent or attenuate surgery-related functional decline and its consequences. The present review is to summarize most recent evidence on the effectiveness of prehabilitation on key topics in cancer care, such as perioperative functional capacity, surgical and oncologic outcomes.

Recent findings
Recent studies predominantly focus on functional outcomes, demonstrating a positive effect of prehabilitation on perioperative physical fitness.

Summary
Prehabilitation prevents functional decline associated with major cancer surgery. Evidence is still needed to support its effectiveness in relation to postoperative complication, length of hospital stay, tumor progression, response to medical treatment, and survival. Ongoing and future research is essential to prompt the role of perioperative medicine in cancer care.
Perioperative Precision Medicine: Where Are We in 2020?
Authors: Pal Nirvik , Kertai Miklos D. 
Published: May 2020

Purpose of review
The present review examines how targeted approaches to care, based on individual variability in patient characteristics, could be applied in the perioperative setting. Such an approach would enhance individualized risk assessment and allow for targeted preventive and therapeutic decision-making in patients at increased risk for adverse perioperative events.

Recent findings
Prior and current studies highlight valuable lessons on how future investigations attempting to link specific patient-related characteristics or treatment modalities with outcomes and adverse drug responses might be designed in the perioperative setting.

Summary
Our review highlights the past, present, and future directions of perioperative precision medicine. Current evidence provides important lessons on how a specific patient and disease tailored approach can help perioperative physicians in delivering the most appropriate and safest perioperative care.