bluuebunny/crossref_metadata_2025_split huggingface dataset:
Level of total bilirubin in the bile of the future remnant liver of patients with obstructive jaundice undergoing hepatectomy predicts postoperative liver failure
Authors: Uemura Shuichiro , Higuchi Ryota , Yazawa Takehisa , Izumo Wataru , Otsubo Takehito , Yamamoto Masakazu 
Published: June 2020

AbstractBackgroundWe investigated whether the daily level of total bilirubin in the bile (LTB) excreted from the future remnant liver (FRL) can predict post‐hepatectomy liver failure (PHLF) in patients with obstructive jaundice undergoing hepatectomy.MethodsSeventy‐four patients who underwent biliary drainage and collection of bile juice from the FRL before undergoing right hepatectomy or right/left trisectionectomy with bile duct resection were included. The LTB from the FRL (mg/d) was calculated as the volume of the bile (dL) per day multiplied by the density of total bilirubin in the bile (mg/dL). We compared patients' characteristics with or without PHLF, which was defined as the total serum bilirubin level remaining >10 mg/dL after postoperative day 10. Then, pre‐ and intraoperative factors related to PHLF were examined.ResultsPHLF was observed in six patients. LTB was significantly lower in the PHLF group. The LTB cut‐off value for predicting PHLF, as determined using the receiver operating characteristic curve, was 56 mg/d. On multivariate analysis, LTB was found to be an independent risk factor for PHLF (P = .01, OR 35.88).ConclusionsLTB may be a potential functional assessment in jaundiced patients before right hepatectomy and right/left trisectionectomy.
Effects of higher and more frequent dosing of alglucosidase alfa and immunomodulation on long‐term clinical outcome of classic infantile Pompe patients
Authors: Poelman Esther , van den Dorpel Jan J. A. , Hoogeveen‐Westerveld Marianne , van den Hout Johanna M. P. , van der Giessen Lianne J. , van der Beek Nadine A. M. E. , Pijnappel W. W. M. Pim , van der Ploeg Ans T. 
Published: June 2020

AbstractThe aim of this study was to compare the long‐term outcome of classic infantile Pompe patients treated with 20 mg/kg alglucosidase alfa every other week (eow) to those treated with 40 mg/kg/week, and to study the additional effect of immunomodulation. Six patients received 20 mg/kg eow and twelve 40 mg/kg/week. Five patients were cross‐reactive immunologic material (CRIM)‐negative, two in the 20 mg, three in the 40 mg group. We compared (ventilator‐free) survival, motor outcome, infusion associated reactions (IARs), and antibody formation. From 2012 on patients >2 months in the 40 mg group also received immunomodulation with rituximab, methotrexate, and intravenous immunoglobulin (IVIG) in an enzyme replacement therapy (ERT)‐naïve setting. Survival was 66% in the 20 mg group and 92% in the 40 mg group. Ventilator‐free survival was 50% and 92%. Both CRIM‐negative patients in the 20 mg group died, whereas all three are alive in the 40 mg group. In the 20 mg group, 67% learned to walk compared with 92% in the 40 mg group. At the age of 3 years, 33% and 92% were able to walk. Peak antibody titers ranged from 1:1250 to 1:31 250 in the 20 mg group and from 1:250 to 1:800 000 in the 40 mg group. Five patients of the 40 mg group of whom two CRIM‐negative also received immunomodulation. B‐cell recovery was observed between 5.7 and 7.9 months after the last dose of rituximab. After B‐cell recovery titers of patients with and without immunomodulation were similar (ranges 1:6 250‐1:800 000 and 1:250‐1:781 250). This study shows that classic infantile patients treated with 40 mg/kg/week from the start to end have a better (ventilator‐free) survival and motor outcome. Immunomodulation did not prevent antibody formation in our study.
Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self‐administering male rats
Authors: Brown Taylor G. , Xu Jin , Hurd Yasmin L. , Pan Ying‐Xian 
Published: June 2020

AbstractHeroin, a mu agonist, acts through the mu opioid receptor. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, creating an array of splice variants that are conserved from rodent to humans. Increasing evidence suggests that these OPRM1 splice variants are pharmacologically important in mediating various actions of mu opioids, including analgesia, tolerance, physical dependence, rewarding behavior, as well as addiction. In the present study, we examine expression of the OPRM1 splice variant mRNAs in the medial prefrontal cortex (mPFC), one of the major brain regions involved in decision‐making and drug‐seeking behaviors, of male human heroin abusers and male rats that developed stable heroin‐seeking behavior using an intravenous heroin self‐administration (SA) model. The results show similar expression profiles among multiple OPRM1 splice variants in both human control subjects and saline control rats, illustrating conservation of OPRM1 alternative splicing from rodent to humans. Moreover, the expressions of several OPRM1 splice variant mRNAs were dysregulated in the postmortem mPFCs from heroin abusers compared to the control subjects. Similar patterns were observed in the rat heroin SA model. These findings suggest potential roles of the OPRM1 splice variants in heroin addiction that could be mechanistically explored using the rat heroin SA model.
Carbon nanotubes functionalized mesoporous silica for in‐tube solid‐phase microextraction of polycyclic aromatic hydrocarbons
Authors: Loussala Herman Maloko , Feng Juanjuan , Han Sen , Sun Min , Ji Xiangping , Li Chunying , Fan Jing , Pei Meishan 
Published: June 2020

AbstractA mesoporous silica was functionalized by carbon nanotubes to enhance the extraction performance. The mesoporous material was coated on stainless steel wires, and three wires were inserted inside of a polyetheretherketone tube for in‐tube solid‐phase microextraction. The tube was coupled to high‐performance liquid chromatography with diode array detection to obtain online analytical system, then its extraction performance was evaluated using eight polycyclic aromatic hydrocarbons as the targets. In order to good sensitivity and accuracy, four conditions were optimized such as sampling volume, sampling rate, methanol content in the sample, and desorption time. Under the optimum conditions, an online analytical method was established and exhibited low limits of detection from 0.005 to 0.050 µg/L, wide linear range of 0.016‐20.00 µg/L with acceptable correlation coefficients in 0.9921‐0.9999, as well as large enrichment factors in the range of 311‐2412. The method was successfully applied to determine trace polycyclic aromatic hydrocarbons in some real water samples including, two kinds of bottled water, tap water, and river water, a few polycyclic aromatic hydrocarbons were detected but none quantified in these samples.
Resolving human DNA mixtures with F‐108 polymer and capillary electrophoresis single‐strand conformational polymorphism analysis
Authors: Jordan Deidra , Mills DeEtta 
Published: June 2020

AbstractCurrent technologies have increased the sensitivity for analyzing forensic DNA samples, especially those considered “touch samples.” Because of this, there has been an increase in the number of forensic mixtures–two or more contributors within a single sample–submitted to the crime laboratories. Therefore, the need to resolve these mixtures has increased as well. Several technologies are currently utilized, but many of them are time consuming and do not resolve the entire profile. Therefore, CE‐Single‐Strand Conformational Polymorphisms coupled with the Pluronic F‐108 polymer was assessed for its ability to resolve human forensic mixtures. This technique has been able to detect sequence variation, such as single nucleotide polymorphism in short tandem repeat loci, such as D7S820 and vWA. Samples were first analyzed with the Performance Optimized Polymer‐7, and mixtures created from samples that shared alleles. These samples were sequenced to detect single base‐pair mutations and evaluated with the F‐108 and CE‐Single Strand Conformational Polymorphism analysis. Results from this study indicated the method would serve as a valuable screening tool to detect base sequence variation between individuals when they share alleles in a mixture and before using Massive Parallel Sequencing technology to distinguish which bases differ.
Layered double hydroxide/poly(vinylpyrrolidone) coated solid phase microextraction Arrow for the determination of volatile organic compounds in water
Authors: Li Xinpei , Lan Hangzhen , Hartonen Kari , Jussila Matti , Wang Xinghua , Riekkola Marja‐Liisa 
Published: June 2020

AbstractToday, wide variety of adsorbents have been developed for sample pretreatment to concentrate and separate harmful substances. However, only a few solid phase microextraction Arrow adsorbents are commercially available. In this study, we developed a new solid phase microextraction Arrow coating, in which nanosheets layered double hydroxides and poly(vinylpyrrolidone) were utilized as the extraction phase and poly(vinyl chloride) as the adhesive. This new coating entailed higher extraction capacity for several volatile organic compounds (allyl methyl sulfide, methyl propyl sulfide, 3‐pentanone, 2‐butanone, and methyl isobutyl ketone) compared to the commercial Carboxen 1000/polydimethylsiloxane coating. Fabrication parameters for the coating were optimized and extraction and desorption conditions were investigated. The validation of the new solid phase microextraction Arrow coating was accomplished using water sample spiked with volatile organic compounds. Under the optimal conditions, the limits of quantification for the five volatile organic compounds by the new solid phase microextraction Arrow coating and developed gas chromatography with mass spectrometry method were in the range of 0.2‐4.6 ng/mL. The proposed method was briefly applied for enrichment of volatile organic compounds in sludge.
Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties
Authors: He Ying‐Jie , Zhu Meng , Zhou Ying , Zhao Kang‐Hong , Zhou Jia‐Li , Qi Zi‐Heng , Zhu Yan‐Yan , Wang Zhao‐Jie , Xie Tian‐Zhen , Tang Qi , Wang Yi‐Fen , Luo Xiao‐Dong 
Published: June 2020

AbstractThe citrus herbs have proved their important medicinal and nutritional values as medicine–food dual‐purpose herbs, functional foods, or medical herbs in China. In this study, phytochemicals and antioxidant activity among ten typical citrus herbs (ethanol extracts) were investigated comprehensively. The major ingredients and their contents were analyzed by high‐resolution mass spectrometry, and the differences of typical fragment ions between flavanone‐7‐O‐rutinoside(s) and flavanone‐7‐O‐neohesperidoside(s) were discriminated properly in negative electrospray ionization mode. Total polyphenols, total flavonoids, 1,1‐diphenyl‐2‐picrylhydrazyl, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid), and ferric reducing antioxidant power tests were performed, which indicated their beneficial values and antioxidant effects. The medicine–food dual‐purpose herbs including Chenpi, Juluo, Daidaihua, Huajuhong, Xiangyuan, and Foshou exhibited antioxidant capacities significantly by decreasing intracellular reactive oxygen species intensity (P < 0.01), enhancing superoxide dismutase, catalase, and glutathione peroxidase activities (P < 0.01) in H2O2‐induced RIN‐m5F cells. Moreover, the functional foods Zhishi, Zhiqiao, and Qingpi showed moderate antioxidant bioactivity, while the medical herb Juhe showed weak antioxidant bioactivity, which were consistent with the multivariate analysis of their major flavonoids. The study provided a new sight for the chemical differentiation and practical application of citrus herbs as medicine–food dual‐purpose herbs, functional foods, or medical herbs.
A fast and green reversed‐phase HPLC method with fluorescence detection for simultaneous determination of amlodipine and celecoxib in their newly approved fixed‐dose combination tablets
Authors: Abdel Hamid Mohamed A. , Mabrouk Mokhtar M. , Michael Mary A. 
Published: June 2020

AbstractA fast, green, sensitive, and accurate analytical method using high‐performance liquid chromatography couple with fluorescence detection was established and validated for the simultaneous determination of amlodipine besylate and celecoxib in their recently approved fixed‐dose combination tablets (1:20). Separation of the two drugs was achieved on C18 reversed‐phase column (Thermo ODS Hypersil, 4.6 × 250 mm, particle size 5 µm) using acetonitrile:potassium phosphate buffer (50 mM; pH 5.5, 60:40 v/v) as a mobile phase at 40°C, which eluted at a rate of 1 mL/min. Detection was carried out with excitation and emission wavelengths of 360 and 446 nm for amlodipine and 265 and 359 nm for celecoxib, respectively. The method was linear over a concentration range of 0.05‐2 and 0.05‐10 µg/mL and limit of detection reached to 0.017 and 0.0167 µg/mL for amlodipine and celecoxib, respectively. The developed method was successfully applied to assess the cited drugs in their newly FDA approved fixed‐dose combination tablet dosage form. Furthermore, the method was found to be sensitive and eco‐friendly green alternative to the reported methods as it was evaluated according to the green analytical procedure index tool guidelines and analytical Eco‐Scale.
A Randomized Controlled Trial of Brief Skills Training in Affective and Interpersonal Regulation (STAIR) for Veterans in Primary Care
Authors: Jain Shaili , Ortigo Kile , Gimeno Julia , Baldor Denine A. , Weiss Brandon J. , Cloitre Marylène 
Published: June 2020

AbstractThis randomized controlled trial assessed the efficacy of a five‐session version of Skills Training in Affective and Interpersonal Regulation (STAIR) among veterans obtaining treatment in primary care. Veterans who screened positive for either posttraumatic stress disorder (PTSD) or depression (N = 26) were enrolled and randomized into either five‐session STAIR or treatment as usual (TAU). Assessments of PTSD symptoms (PTSD Checklist for DSM‐5; PCL‐5), depression (Beck Depression Inventory–II; BDI‐II), emotion regulation (Difficulties in Emotion Regulation Scale; DERS), and social engagement difficulties (World Health Organization Disability Assessment 2.0; WHODAS‐2) were assessed at pretreatment, posttreatment, and 3‐month follow‐up assessments. Participants assigned to the five‐session STAIR condition reported significant improvements on all measures, whereas those assigned to TAU showed no change. Group × Treatment interactions were significant for all outcomes, and effect sizes for the interactions ranged from moderate to large, Hedge's gs = 0.81 for the PCL‐5, 1.15 for the BDI‐II, 0.75 for the DERS, and 0.81 for the WHODAS‐2. The results indicate that five‐session STAIR, a brief, skills‐focused treatment, may be effective in reducing a range of symptoms and in improving social functioning among veterans treated in primary care settings.
Thermal decomposition of N2O near 900 K studied by FTIR spectrometry: Comparison of experimental and theoretical O(3P) formation kinetics
Authors: Pham Tien V. , Tsay T. J. , Lin M. C. 
Published: June 2020

AbstractThe spin‐forbidden dissociation reaction of the N2O(X1Σ+) ground state has been investigated by both quantum calculations and experiments. Ab initio prediction at the CCSD(T)/CBS(TQ5)//CCSD(T)/aug‐cc‐pVTZ+d level of theory gave the crossing point (MSX) energy at 60.1 kcal/mol for the N2O(X1Σ+) → N2() + O(3P) transition, in good agreement with published data. TheT‐ andP‐dependent rate coefficients,k1(T,P), for the nonadiabatic thermal dissociation predicted by nonadiabatic Rice‐Ramsperger‐Kassel‐Marcus (RRKM) calculations agree very well with literature data. The rate constants at the high‐ and low‐pressure limits,k1∞ = 1011.90exp (−61.54 kcal mol−1/RT) s−1andk1o = 1014.97exp(−60.05 kcal mol−1/RT) cm3mol−1s−1, for example, agree closely with the extrapolated results of Röhrig et al. at both pressure limits. The second‐order rate constant (k1o) is also in excellent agreement with our result measured by FTIR spectrometry in the present study for the temperature range of 860‐1023 K as well as with many existing high‐temperature data obtained primarily by shock‐wave heating up to 3340 K. Kinetic modeling of the NO product yields measured at long reaction times in the present work also allowed us to reliably estimate the rate constant for reaction (3), O + N2O → N2+ O2, based on its strong competition with the NO formation from reaction (2) which has been better established. The modeled values ofk3confirmed the previous finding by Davidson et al. with significantly smaller values ofA‐factor and activation energy than the accepted ones. A least‐squares analysis of both sets of data gavek3 = 1012.22 ± 0.04exp[− (11.65 ± 0.24 kcal mol−1/RT)] cm3mol−1s−1, covering the wide temperature range of 988‐3340 K.
Genomics and Liver Transplantation: Genomic Biomarkers for the Diagnosis of Acute Cellular Rejection
Authors: Kohut Taisa J. , Barandiaran Jose F. , Keating Brendan J. 
Published: June 2020

Acute cellular rejection (ACR) is a common complication in liver transplantation recipients (LTRs), especially within the first 12 months, and it is associated with increased morbidity and mortality. Although abnormalities in standard liver biochemistries may raise the clinical suspicion for ACR, it lacks specificity, and invasive liver biopsies, which are associated with numerous risks, are required for definitive diagnoses. Biomarker discovery for minimally invasive tools for diagnosis and prognostication of ACR after liver transplantation (LT) has become a rapidly evolving field of research with a recent shift in focus to omics‐based biomarker discovery. Although none are yet ready to replace the standard of care, there are several promising minimally invasive, blood‐derived biomarkers that are under intensive research for the diagnosis of ACR in LTRs. These omics‐based biomarkers, encompassing DNA, RNA, proteins, and metabolites, hold tremendous potential. Some are likely to become integrated into ACR diagnostic algorithms to assist clinical decision making with a high degree of accuracy that is cost‐effective and reduces or even obviates the need for an invasive liver biopsy.
HOW OUTSTANDING LEADERS USE EMOTIONAL INTELLIGENCE
Authors: Cherniss Cary , Roche Cornelia W. 
Published: June 2020

AbstractThe popularity of emotional intelligence among business leaders is based in part on the realization that cognitive intelligence, or “IQ,” accounts for only part of what leaders need to be effective. A meta‐analysis combining the results from 151 independent studies and over 40,000 leaders found that IQ accounted for only about 7% of the variability in leader effectiveness. Emotional intelligence is the ability to perceive, understand, and manage our own emotions and those of others. We have studied how 25 outstanding leaders have used their emotional intelligence to confront critical challenges and opportunities. Using a modified behavior event interview, we asked the leaders to describe “one or more incidents in which they used or managed their own emotions and/or those of others to deal with a challenge or opportunity.” We identified nine strategies that the leaders used often. In this article, we describe each strategy. In their roles as supervisors, managers, or executives, organizational leaders are in a particularly good position to help others develop emotional intelligence. Organizational leaders are often able to see their people behaving in various real‐life situations on multiple occasions over time. They also are better able to provide feedback immediately or soon after an incident.
Identification of two decision‐making paths underpinning the continued use of branded apps
Authors: Stocchi Lara , Pourazad Naser , Michaelidou Nina 
Published: June 2020

AbstractThis study investigates two decision‐making paths that underpin the continued use of branded apps. One path originates from past use of a category of apps and leads to continued use of a branded app from that category via recognition. The second path also starts with past use, but leads to continued use through the evaluation of the app's benefits. Two empirical studies test and subsequently validate the resulting conceptual model, confirming that both paths underpin continued use; however, the strength of the theoretical links varies, and the two paths warrant separate investigation. These outcomes support the generalizability of the proposed model, highlighting its potential as a tool to advance the understanding of consumer decision‐making leading to the continued use of branded apps. The findings of this study also yield practical relevance, especially for the delineation of strategies to enhance the chances of market survival of branded apps.
Subjective Cognitive Complaint in Parkinson's Disease Patients With Normal Cognition: Canary in the Coal Mine?
Authors: Purri Rachael , Brennan Laura , Rick Jacqueline , Xie Sharon X. , Deck Benjamin L. , Chahine Lana M. , Dahodwala Nabila , Chen‐Plotkin Alice , Duda John E. , Morley James F. , Akhtar Rizwan S. , Trojanowski John Q. , Siderowf Andrew , Weintraub Daniel 
Published: June 2020

AbstractObjectiveThe objective of this study was to determine the frequency and impact of subjective cognitive complaint (SCC) in Parkinson's disease (PD) patients with normal cognition.MethodsPatients with PD with expert consensus‐determined normal cognition at baseline were asked a single question regarding the presence of SCC. Baseline (N = 153) and longitudinal (up to 4 follow‐up visits during a 5‐year period; N = 121) between‐group differences in patients with PD with (+SCC) and without (−SCC) cognitive complaint were examined, including cognitive test performance and self‐rated and informant‐rated functional abilities.ResultsA total of 81 (53%) participants reported a cognitive complaint. There were no between‐group differences in global cognition at baseline. Longitudinally, the +SCC group declined more than the −SCC group on global cognition (Mattis Dementia Rating Scale–2 total score, F1,431 = 5.71, P = 0.02), processing speed (Symbol Digit Modalities Test, F1,425 = 7.52, P = 0.006), and executive function (Trail Making Test Part B, F1,419 = 4.48, P = 0.04), although the results were not significant after correction for multiple testing. In addition, the +SCC group was more likely to progress to a diagnosis of cognitive impairment over time (hazard ratio = 2.61, P = 0.02). The +SCC group also demonstrated significantly lower self‐reported and knowledgeable informant–reported cognition‐related functional abilities at baseline, and declined more on an assessment of global functional abilities longitudinally.ConclusionsPatients with PD with normal cognition, but with SCC, report poorer cognition‐specific functional abilities, and are more likely to be diagnosed with cognitive impairment and experience global functional ability decline long term. These findings suggest that SCC and worse cognition‐related functional abilities may be sensitive indicators of initial cognitive decline in PD. © 2020 International Parkinson and Movement Disorder Society