bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and genetic validation of drug-comorbidity interactions in type 2 diabetes using data-driven disease trajectory analysis
Authors: Ichikawa Osamu , Glicksberg Benjamin S. , Minsky Noga , Lee Hao-Chih , Li Shuyu D. , Chen Rong , Li Li , Dudley Joel T. 
Published: October 2019

AbstractGiven various risk profiles, manifestations, comorbidities, and outcomes for individuals with Type 2 diabetes mellitus (T2D), a one-size-fits-all approach towards treatment and management is inadequate, and there is a clear need for personalized medications to reduce rates of complications and comorbidities. Here, we leveraged comprehensive Electronic Medical Records (EMR) to identify associations between T2D comorbidities and medications and evaluated their biological determinants using EMR-linked genetic information. We discovered clinically novel associations supported by the previous laboratory studies; e.g. 5-hydroxytryptamine 3 receptor antagonists, ondansetron and granisetron, are protective against cognitive disorders, and clopidogrel is protective against retinopathy. Furthermore, potentially novel associations were validated by genetic analysis; e.g. association between gabapentin and cognitive disorders was supported via variants of its target genes,GRIN1andCACNA2D2. These results of the current study open the door for optimizing treatment combinations to mitigate risks and for individualizing therapy based on T2D subtype risk profiles.
Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O-Mannose-Type Galactomannans within the Invasive PathogenAspergillus fumigatus
Authors: Chihara Yuria , Tanaka Yutaka , Izumi Minoru , Hagiwara Daisuke , Watanabe Akira , Takegawa Kaoru , Kamei Katsuhiko , Shibata Nobuyuki , Ohta Kazuyoshi , Oka Takuji 
Published: October 2019

ABSTRACTThe pathogenic fungusAspergillus fumigatuscontains galactomannans localized on the surface layer of its cell walls, which are involved in various biological processes. Galactomannans comprise α-(1→2)-/α-(1→6)-mannan and β-(1→5)-/β-(1→6)-galactofuranosyl chains. We previously revealed that GfsA is a β-galactofuranoside β-(1→5)-galactofuranosyltransferase involved in the biosynthesis of β-(1→5)-galactofuranosyl chains. Here, we clarified the entire biosynthesis of β-(1→5)-galactofuranosyl chains inA. fumigatgus. Two paralogs exist withinA. fumigatus: GfsB and GfsC. We show that GfsB and GfsC, in addition to GfsA, are β-galactofuranoside β-(1→5)-galactofuranosyltransferases by biochemical and genetic analyses. GfsA, GfsB, and GfsC can synthesize β-(1→5)-galactofuranosyl oligomers up to lengths of 7, 3, and 5 galactofuranoses within an establishedin vitrohighly efficient assay of galactofuranosyltransferase activity. Structural analyses of galactomannans extracted from the strains ΔgfsB, ΔgfsC, ΔgfsAC, and ΔgfsABCrevealed that GfsA and GfsC synthesized all β-(1→5)-galactofuranosyl residues of fungal-type and O-mannose-type galactomannans, and GfsB exhibited limited function inA. fumigatus. The loss of β-(1→5)-galactofuranosyl residues decreased the hyphal growth rate and conidia formation ability as well as increased the abnormal hyphal branching structure and cell surface hydrophobicity, but this loss is dispensable for sensitivity to antifungal agents and virulence toward immune-compromised mice.IMPORTANCEβ-(1→5)-galactofuranosyl residues are widely distributed in the subphylum Pezisomycotina of the phylum Ascomycota. Pezizomycotina includes many plant and animal pathogens. Although the structure of β-(1→5)-galactofuranosyl residues of galactomannans in filamentous fungi was discovered long ago, it remains unclear which enzyme is responsible for biosynthesis of this glycan. Fungal cell wall formation processes are complicated, and information concerning glycosyltransferases is essential for their understanding. In this study, we show that GfsA and GfsC are responsible for the biosynthesis of all β-(1→5)-galactofuranosyl residues of fungal-type and O-mannose-type galactomannans. The data presented here indicates that β-(1→5)-galactofuranosyl residues are involved in cell growth, conidiation, polarity, and cell surface hydrophobicity. Our new understanding of β-(1→5)-galactofuranosyl residue biosynthesis provides important novel insights into the formation of the complex cell wall structure and the virulence of the subphylum Pezisomycotina.
Multiple layers of phospho-regulation coordinate metabolism and the cell cycle in budding yeast
Authors: Zhang Lichao , Winkler Sebastian , Schlottmann Fabian , Kohlbacher Oliver , Elias Josh E. , Skotheim Jan M. , Ewald Jennifer C. 
Published: October 2019

AbstractThe coordination of metabolism and growth with cell division is crucial for proliferation. While it has long been known that cell metabolism regulates the cell division cycle, it is becoming increasingly clear that the cell division cycle also regulates metabolism. In budding yeast, we previously showed that over half of all measured metabolites change concentration through the cell cycle indicating that metabolic fluxes are extensively regulated during cell cycle progression. However, how this regulation is achieved still remains poorly understood. Since both the cell cycle and metabolism are regulated to a large extent by protein phosphorylation, we here decided to measure the phosphoproteome through the budding yeast cell cycle. Specifically, we chose a cell cycle synchronisation strategy that avoids stress and nutrient-related perturbations of metabolism, and we grew the yeast on ethanol minimal medium to force cells to utilize their full biosynthetic repertoire. Using a tandem-mass-tagging approach, we found over 200 sites on metabolic enzymes and transporters to be phospho-regulated. These sites were distributed among many pathways including carbohydrate catabolism, lipid metabolism and amino acid synthesis and therefore likely contribute to changing metabolic fluxes through the cell cycle. Among all one thousand sites whose phosphorylation increases through the cell cycle, the CDK consensus motif and an arginine-directed motif were highly enriched. This arginine-directed R-R-x-S motif is associated with protein-kinase A, which regulates metabolism and promotes growth. Finally, we also found over one thousand sites that are dephosphorylated through the G1/S transition. We speculate that the phosphatase Glc7/ PP1, known to regulate both the cell cycle and carbon metabolism, may play an important role because its regulatory subunits are phospho-regulated in our data. In summary, our results identify extensive cell cycle dependent phosphorylation and dephosphorylation of metabolic enzymes and suggest multiple mechanisms through which the cell division cycle regulates metabolic signalling pathways to temporally coordinate biosynthesis with distinct phases of the cell division cycle.
Towards corporate transparency
Authors: Esterhuyse Leana 
Published: October 2019

Purpose
The purpose of this paper is to determine whether companies recognised for the quality of their sustainability reporting are also adopting investor relations (IR) best practices for their IR webpages. Quality communications to all stakeholder groups may then speak to organisational transparency and integrated corporate communication management (CCM).

Design/methodology/approach
An ordinary least squares regression model was developed to test the hypothesis that companies with quality sustainability reporting also adopts best practices in online IR. Sustainability reporting quality was signalled by inclusion of the company in a socially responsible investment (SRI) index. IR quality was proxied by disclosure scores compiled from content analyses of investor relations webpages.

Findings
This study find that inclusion in the SRI Index was positively and significantly associated with online IR quality, while controlling for other variables associated with voluntary disclosure behaviour.

Practical implications
For retail and institutional investors in SRI Index companies, cost of information discovery is reduced as they can use the investor relations webpages as comprehensive source.

Originality/value
This study contributes to the literature on corporate transparency by operationalising reporting “transparency” in that it considers the combined communications output to both financial and non-financial stakeholder groupings. A 2 × 2 conceptual framework for corporate disclosures is proposed that reconciles legitimacy theory and voluntary disclosure theory as motivations. It also contributes to the paucity of research on the links between public relations and investor relations in corporate communications by demonstrating a joint contribution to transparency.
The cyber-insurance market in Norway
Authors: Bahşi Hayretdin , Franke Ulrik , Friberg Even Langfeldt 
Published: October 2019

PurposeThis paper aims to describe the cyber-insurance market in Norway but offers conclusions that are interesting to a wider audience.Design/methodology/approachThe study is based on semi-structured interviews with supply-side actors: six general insurance companies, one marine insurance company and two insurance intermediaries.FindingsThe Norwegian cyber-insurance market supply-side has grown significantly in the past two years. The General Data Protection Regulation (GDPR) is found to have had a modest effect on the market so far but has been used by the supply-side as an icebreaker to discuss cyber-insurance with customers. The NIS Directive has had little or no impact on the Norwegian cyber-insurance market until now. Informants also indicate that Norway is still the least mature of the four Nordic markets.Practical implicationsSome policy lessons for different stakeholders are identified.Originality/valueEmpirical investigation of cyber-insurance is still rare, and the paper offers original insights on market composition and actor motivations, ambiguity of coverage, the NIS Directive and GDPR.
Enhancing cyber security behavior: an internal social marketing approach
Authors: Pham Hiep Cong , Brennan Linda , Parker Lukas , Phan-Le Nhat Tram , Ulhaq Irfan , Nkhoma Mathews Zanda , Nhat Nguyen Minh 
Published: October 2019

Purpose
Understanding the behavioral change process of system users to adopt safe security practices is important to the success of an organization’s cybersecurity program. This study aims to explore how the 7Ps (product, price, promotion, place, physical evidence, process and people) marketing mix, as part of an internal social marketing approach, can be used to gain an understanding of employees’ interactions within an organization’s cybersecurity environment. This understanding could inform the design of servicescapes and behavioral infrastructure to promote and maintain cybersecurity compliance.

Design/methodology/approach
This study adopted an inductive qualitative approach using in-depth interviews with employees in several Vietnamese organizations. Discussions were centered on employee experiences and their perceptions of cybersecurity initiatives, as well as the impact of initiatives on compliance behavior. Responses were then categorized under the 7Ps marketing mix framework.

Findings
The study shows that assessing a cybersecurity program using the 7P mix enables the systematic capture of users’ security compliance and acceptance of IT systems. Additionally, understanding the interactions between system elements permits the design of behavioral infrastructure to enhance security efforts. Results also show that user engagement is essential in developing secure systems. User engagement requires developing shared objectives, localized communications, co-designing of efficient processes and understanding the “pain points” of security compliance. The knowledge developed from this research provides a framework for those managing cybersecurity systems and enables the design human-centered systems conducive to compliance.

Originality/value
The study is one of the first to use a cross-disciplinary social marketing approach to examine how employees experience and comply with security initiatives. Previous studies have mostly focused on determinants of compliance behavior without providing a clear platform for management action. Internal social marketing using 7Ps provides a simple but innovative approach to reexamine existing compliance approaches. Findings from the study could leverage proven successful marketing techniques to promote security compliance.
Patient use of online medical records: an application of technology acceptance framework
Authors: Mukhopadhyay Surma , Basak Ramsankar , Carpenter Darrell , Reithel Brian J. 
Published: October 2019

PurposeLittle is known about factors that affect patient use of online medical records (OMR). Specifically, with rising vulnerability concerns associated with security and privacy breaches, patient use of OMR requires further attention. This paper aims to investigate patient use of OMR. Using the Unified Theory of Acceptance and Use of Technology (UTAUT), factors affecting continued use of OMR were examined.Design/methodology/approachThe Health Information National Trends Survey 5 (HINTS 5), Cycle 1 data were used. This is an ongoing nation-wide survey sponsored by the National Cancer Institute (NCI) of the USA. The subjects were 31-74 years old with access to the Internet. Descriptive information was projected to the US population.FindingsIn total, 765 respondents representing 48.7 million members of the US population were analyzed. Weighted regression results showed significant effects of perceived usefulness, visit frequency and provider encouragement on continued use of OMR while vulnerability perception was not significant. Moderating effects of these variables were also noted. Perceived usefulness and provider encouragement emerged as important predictors.Practical implicationsInsights may help design interventions by health-care providers and policymakers.Social implicationsInsights should help patient empowerment and developers with designing systems.Originality/valueThis is the first study to examine health-care consumers’ continued use of OMR using nationally representative data and real-world patients, many of who have one or more chronic diseases (e.g. diabetes, hypertension, asthma) or are cancer survivors. Results highlight factors helping or hindering continuing OMR use. As such, insights should help identify opportunities to increase the extent of use, project future OMR usage patterns and spread the benefits of OMR, including bringing forth positive health outcomes.
Route classification scheme based on covering rough set approach in mobile ad hoc network (CRS-MANET)
Authors: T. Sudhakar , H. Hannah Inbarani , S. Senthil Kumar 
Published: October 2019

Purpose
The purpose of this paper is to obtain correctly classified routes based on their parameters.

Design/methodology/approach
In this paper, a covering rough set (CRS) approach is proposed for route classification in wireless ad hoc networks. In a wireless network, mobile nodes are deployed randomly in a simulation region. This work addresses the problem of route classification.

Findings
The network parameters such as bandwidth, delay, packet byte rate and packet loss rate changes due to the frequent mobility of nodes lead to uncertainty in wireless networks. This type of uncertainty can be very well handled using a rough set concept. An ultimate aim of classification is to correctly predict the decision class for each instance in the data.

Originality/value
The traditional classification algorithms, named K-nearest neighbor, J48, general rough set theory, naive Bayes, JRIP and multilayer perceptron, are used in this work for comparison and for the proposed CRS based on route classification approach revealing better accuracy than traditional classification algorithms.
Improving system reliability by optimal allocation of resources for discovering software vulnerabilities
Authors: Bhatt Navneet , Anand Adarsh , Aggrawal Deepti 
Published: October 2019

PurposeThe purpose of this paper is to provide a mathematical framework to optimally allocate resources required for the discovery of vulnerabilities pertaining to different severity risk levels.Design/methodology/approachDifferent sets of optimization problems have been formulated and using the concept of dynamic programming approach, sequence of recursive functions has been constructed for the optimal allocation of resources used for discovering vulnerabilities of different severity scores. Mozilla Thunderbird web browser data set has been considered for giving the empirical evaluation by working with vulnerabilities of different severities.FindingsAs per the impact associated with a vulnerability, critical and high severity level are required to be patched promptly, and hence, a larger amount of funds have to be allocated for vulnerability discovery. Nevertheless, a low or medium risk vulnerability might also get exploited and thereby their discovery is also crucial for higher severity vulnerabilities. The current framework provides a diversified allocation of funds as per the requirement of a software manager and also aims at improving the discovery of vulnerability significantly.Practical implicationsThe finding of this research may enable software managers to adequately assign resources in managing the discovery of vulnerabilities. It may also help in acknowledging the funds required for various bug bounty programs to cater security reporters based on the potential number of vulnerabilities present in software.Originality/valueMuch of the attention has been focused on the vulnerability discovery modeling and the risk associated with the security flaws. But, as far as the authors’ knowledge is concern, there is no such study that incorporates optimal allocation of resources with respect to the vulnerabilities of different severity scores. Hence, the building block of this paper contributes to future research.
Coworking space as a third-fourth place: changing models of a hybrid space in corporate real estate
Authors: Yang Eunhwa , Bisson Catherine , Sanborn Bonnie Eaton 
Published: October 2019

Purpose
This paper aims to review the concept and characteristics of coworking space, especially physical and operational characteristics and its objectives. The authors propose three models of coworking spaces, such as revenue, synergistic and customer contact, which organizations can use as a part of their corporate real estate strategies to build workplace flexibility and resiliency. This paper also addresses research gaps and a research agenda for future research.

Methodology
This paper is a literature review of academic research focusing on coworking spaces. Because of the relatively limited existing academic literature on the topic, industry sources and white papers are also reviewed.

Findings
The authors categorized common threads of the existing literature on coworking spaces to emergence and growth trends, the types of users, the type of work to be completed in these spaces, characteristics of coworking spaces and the desired outcomes of coworking space models. Coworking spaces are expected to grow worldwide because of the increase in knowledge-based economy, the “digital nomad” lifestyle and mobile technologies, however, there is limited research on the relationship between spatial and operational characteristics of coworking spaces and users’ collaboration, social well-being and creativity. No research identified fully articulated the nuanced differences between the types of coworking spaces now found in the real estate ecosystem.

Research limitations
There is limited academic, empirical research focusing on coworking spaces. Thus, the search for literature itself is limited to a small number of papers. Although the authors extended the search to non-academic sources, the conclusion of this study is tentative because of the prematurity of the topic.

Originality/value
This paper urges the identification of research questions, considering the fast growth of coworking spaces and suggests future research directions based on newly proposed models. Industry practitioners, including building owners, managers, coworking space providers and corporate real estate practitioners, can consider using variations of coworking space concepts and characteristics, as they understand the importance of social needs and connectivity among users. By addressing the history of the coworking space as a concept and business model, and updating the types of models to include new coworking spaces, the authors provide further options to industry practitioners as to how to integrate coworking into their real estate.
Portfolio allocation across variance risk premia
Authors: Chevallier Julien , Vo Dinh-Tri 
Published: October 2019

PurposeIn asset management, what if clients want to purchase protection from risk factors, under the form of variance risk premia. This paper aims to address this topic by developing a portfolio optimization framework based on the criterion of the minimum variance risk premium (VRP) for any investor selecting stocks with an expected target return while minimizing the risk aversion associated to the portfolio according to “good” and “bad” times.Design/methodology/approachTo accomplish this portfolio selection problem, the authors compute variance risk-premium as the difference from high-frequencies' realized volatility and options' implied volatility stemming from 19 stock markets, estimate a 2-state Markov-switching model on the variance risk-premia and optimize variance risk-premia portfolios across non-overlapping regions. The period goes from March 16, 2011, to March 28, 2018.FindingsThe authors find that optimized portfolios based on variance-covariance matrices stemming from VRP do not consistently outperform the benchmark based on daily returns. Several robustness checks are investigated by minimizing historical, realized or implicit variances, with/without regime switching. In a boundary case, accounting for the realized variance risk factor in portfolio decisions can be seen as a promising alternative from a portfolio performance perspective.Practical implicationsAs a new management “style”, the realized volatility approach can, therefore, bring incremental value to construct the conditional covariance matrix estimates.Originality/valueThe authors assess the portfolio performance determined by the variance-covariance matrices that are derived by four models: “naive” (Markowitz returns benchmark), non-switching VRP, maximum likelihood regime-switching VRP and Bayesian regime switching VRP. The authors examine the best return-risk combination through the calculation of the Sharpe ratio. They also assess another different portfolio strategy: the risk parity approach.
Relationship between human resource management practices and informal workplace learning
Authors: Khandakar Md Shariful Alam , Pangil Faizuniah 
Published: October 2019

PurposeThis study aims to examine the relationship between human resource management (HRM) practices and informal workplace learning.Design/methodology/approachData were collected from a sample of 381 employees working as heads of the department of branches in private commercial banks of Bangladesh. Hypotheses were tested by using structural equation modelling-partial least square.FindingsFindings of the study revealed that HRM practices such as selective hiring, extensive training, performance appraisal, compensation practices, empowerment and information-sharing, significantly positively related with informal workplace learning.Originality/valueBased on the situated learning and organizational support theory, this study is empirically testing how HRM practices influence informal workplace learning.