bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Umbilical Cord C-Peptide Levels in Early Prediction of Hypoglycemia in Infants of Diabetic Mothers
Authors: Saber Ahlam , Mohamed Magdy , Sadek Abdelrahim , Mahmoud Ramadan 
Published: November 2020

Abstract
Background: Until now, diabetes during pregnancy has been associated with a high risk of maternal, fetal, and neonatal morbidities and mortalities. The main aim of this study was to evaluate the risk factors of hypoglycemia in infants of diabetic mothers (IDMs) and to study the relationship between umbilical cord (UC) C peptide levels and the risk of developing hypoglycemia.Material and methods: UC blood C-peptide and serial serum blood glucose measurements were done for all included singleton newborns born to diabetic mothers during the study period. Maternal and neonatal data such as gestational age, maternal age, maternal weight, types of diabetics and its control, maternal glycated hemoglobin (HbA1C), birth weight, Apgar score, and neonatal complete blood picture were collected.Results: In total, 83 IDMs met the inclusion criteria. Fifty-four (65.06%) developed hypoglycemia and 29 (34.94%) remained normoglycemic. However, there were no significant differences between hypoglycemic and normoglycemic IDMs in terms of types of maternal diabetics (P value = 0.41), its duration (P value= 0.43). The hypoglycemia peak occurred within the first 3 hours of life, with 33.11 ± 8.84 mg/dl for the hypoglycemia group and 54.10 ± 6.66 mg/dl for the normoglycemic group (P value < 0.0001). Most of the babies had no hypoglycemic manifestation (96.30%). Neonates with hypoglycemia their mothers had poor diabetes control in the last trimester (HbA1C 7.09 ± 0.96) compared to normoglycemic babies (HbA1C 6.11 ± 0.38), (P-value < 0.0001). The mean (SD) of UC C-peptide level in hypoglycemic neonates increased to 1.73 ± 1.07 ng/ml compared to normoglycemic ones with 1.08 ± 0.81 ng/ml (P value = 0.005).Conclusion: Poor diabetes control, especially in the last trimester, is associated with neonatal hypoglycemia. Increased UC C-peptide levels could be used as an early indicator for the risk of developing neonatal hypoglycemia and a predictor for babies need neonatal admission.
Understanding and Recognition of the Right Ventricular Function and Dysfunction: A Numerical Study
Authors: Comunale Giulia , Peruzzo Paolo , Castaldi Biagio , Razzolini Renato , Salvo Giovanni Di , Padalino Massimo , Susin Francesca 
Published: November 2020

Abstract
The role played by the right ventricular (RV) dysfunction has long been underestimated in clinical practice. Recent findings are progressively confirming that when the RV efficiency deteriorates both the right and the left circulation is (significantly) affected, but studies dedicated to a detailed description of RV hemodynamic role still lack. In response to such a gap in knowledge, this work proposes a numerical model that for the first time evaluates the effect of isolated RV dysfunction on the whole circulation. Lumped parameter modelling was applied to represent the physio-pathological hemodynamics. Different grades of impairment were simulated for three dysfunctions i.e., systolic, diastolic, and combined systolic and diastolic. Hemodynamic alterations (i.e., of blood pressure, flow, global hemodynamic parameters), arising from the dysfunctions, are calculated and analysed. Results well accord with clinical observations, showing that RV dysfunction significantly affects both the pulmonary and systemic hemodynamics. Successful validation against in vivo data proved the clinical potentiality of the model i.e., the capability of identifying the degree of RV impairment for given hemodynamic conditions. This study aims at contributing to the improvement of RV dysfunction recognition and treatment, and to the development of tools for the clinical management of pathologies involving the right heart.
A Principal Components Analysis of Factors Associated with Successful Implementation of an LVAD Decision Support Tool
Authors: Kostick Kristin M. , Trejo Meredith , Bhimaraj Arvind , Civitello Andrew , Grinstein Jonathan , Horstmanshof Douglas , Jorde Ulrich P. , Loebe Matthias , Mehra Mandeep R. , Sulemanjee Nasir Z. , Thohan Vinay , Trachtenberg Barry H. , Uriel Nir , Volk Robert J. , Estep Jerry D. , Blumenthal-Barby J. S. 
Published: November 2020

Abstract
BackgroundA central goal among researchers and policy makers seeking to implement clinical interventions is to identify key facilitators and barriers that contribute to implementation success. Despite calls from a number of scholars, empirical insights into the complex structural and cultural predictors of why DAs become routinely embedded in health care settings remains limited and highly variable across implementation contexts.MethodsWe examined associations between “reach”, a widely used indicator (from the RE-AIM model) of implementation success, and multi-level site characteristics of nine LVAD clinics engaged over 18 months in implementation and dissemination of a decision aid for left-ventricular assist device (LVAD) treatment. Based on data collected from nurse coordinators, we explored factors at the level of the organization (e.g. patient volume), patient population (e.g. health literacy; average sickness level), clinician characteristics (e.g. attitudes towards decision aid; readiness for change) and process (how the aid was administered). We generated descriptive statistics for each site and calculated zero-order correlations (Pearson’s r) between all multi-level site variables including cumulative reach at 12 months and 18 months for all sites. We used principal components analysis (PCA) to examine any latent factors governing relationships between and among all site characteristics, including reach.ResultsWe observed strongest inclines in reach of our decision aid across the first year, with uptake fluctuating over the second year. Average reach across sites was 63% (s.d.=19.56) at 12 months and 66% (s.d.=19.39) at 18 months. Our (PCA) revealed that site characteristics positively associated with reach on two distinct dimensions, including a first dimension reflecting greater organizational infrastructure and standardization (characteristic of larger, more established clinics) and a second dimension reflecting positive attitudinal orientations, specifically, openness and capacity to give and receive decision support among coordinators and patients.ConclusionsSuccessful implementation plans should incorporate specific efforts to promote supportive and mutually informative interactions between clinical staff members and to institute systematic and standardized protocols to enhance the availability, convenience and salience of intervention tool in routine practice. Further research is needed to understand whether “core predictors” of success vary across different intervention types.
Effects of Abiotic Elicitors on Expression and Accumulation of Three Candidate Benzophenanthridine Alkaloids in Cultured Greater Celandine Cells&nbsp;
Authors: Hashemi Seyed Mohammad , Naghavi Mohammadreza , Ghorbani Mehdi , Zandi Peiman 
Published: November 2020

Abstract
Efforts to develop the necessary biotechnologies in Greater Celandine (Chelidonium majus L.), a leading plant resource for the development of plant-derived medicines, have been hampered by the lack of knowledge about transcriptome and metabolome regulations of its medicinal components. Therefore, this study aimed to examine the effect of abiotic elicitors, methyl jasmonate (MJ) and salicylic acid (SA), at different time courses (12, 24, 48, and 72 h), on expression and metabolome of key benzophenanthridine alkaloids (BPAs) in an optimized in vitro culture. Gene expression analysis indicated the up-regulation of CFS to 2.62, 4.85, and 7.28 times higher than the control at 12, 24, and 48 h, respectively, under MJ elicitation. Besides, MJ up-regulated the expression of TNMT to 2.79, 4.75, and 7.21 times at 12, 24, and 48 h, respectively, compared to the control. Investigation of BPAs revealed a significant enhancement in the chelidonine content (9.86 µg/mg) after 72 h of MJ elicitation. Additionally, sanguinarine content increased to its highest level (3.42 µg/mg) after 24 h of MJ elicitation; however, no significant enhancement was detected in its content in shorter elicitation time courses. Generally, higher gene expression and BPAs’ level was observed through longer elicitation courses (48 and 72 h). Our findings take part in improving the understanding of transcription and metabolic regulation of BPAs in cultured Greater Celandine cells.
Associations Between Predialysis Creatinine, SOFA Score, and Mortality in Acute Kidney Injury Patients Requiring Dialysis
Authors: Chang Hsin-Hsiung , Wu Chia-Lin , Chiu Ping-Fang 
Published: November 2020

Abstract
Background: Creatinine is widely used to estimate renal function, but this is not practical in critical illness. Low creatinine has been associated with mortality in many clinical settings. However, the associations between predialysis creatinine level, Sepsis-related Organ Failure Assessment (SOFA) score, and mortality in acute kidney injury patients receiving dialysis therapy (AKI-D) has not been fully addressed. Methods: We extracted data for AKI-D patients in the eICU (n = 1,992) and MIMIC (n = 1,001) databases. We conducted a retrospective observational cohort study using the eICU dataset. The study cohort was divided into the high-creatine group and the low-creatinine group by the median value (4 mg/dL). The baseline patient information included demographic data, laboratory parameters, medications, and comorbid conditions. The independent association of creatinine level with mortality was examined using multivariate logistic regression analysis. We also carried out a sensitivity analysis using the MIMIC dataset.Results: In all 1,992 eICU participants, the 30-day intensive care unit mortality rate was 32.2%. The crude overall mortality rate in the low-creatinine group (43.7%) was significantly higher than that in the high-creatinine group (20.6%; P < 0.001). In the fully adjusted models, the high-creatinine group was associated with a lower risk of all-cause mortality (odds ratio, 0.56; 95% confidence interval, 0.42–0.75; P < 0.001) compared with the low-creatinine group. The nonrenal SOFA score was higher in the low-creatinine group. The results were consistent when the MIMIC dataset was used as an external validation dataset.Conclusions: AKI-D patients with a low predialysis creatinine value had a significantly higher risk of mortality that might be associated with more organ dysfunctions. Moreover, SOFA and nonrenal SOFA scores did not sufficiently reflect the severity of illness without considering the impact of the creatinine value in AKI-D patients.
Content Validation of Educational Materials on Maternal Depression in Nigeria
Authors: Adefolarin Adeyinka Olufolake , Asiki Gershim 
Published: November 2020

Abstract
BackgroundContent validation is a process of obtaining evidence from experts to ensure that the domains or the message of a measurement tool or educational material performs its intended purpose. This study describes the validation of developed educational materials (poster, leaflet and song), which are available in local languages for health education on maternal depression in Ibadan, South-West, Nigeria. MethodsThis cross sectional study used experts’ judgement and clients’ evaluation. Six experts and 50 maternal-child health clients for each material participated. Suitability Assessment of Materials (SAM) tool and its Yoruba translated version were used by the experts and the clients respectively. The outcomes include Cronbach alpha coefficient ≥ 0.8, Item level- Content Validity Index (I-CVI) ≥0.78, Scale – Item Content Validity/ Universal Agreement (S-ICV/UA) ≥ 0.8, interclass coefficient (ICC)0 ≥0.7, and the proportion of of rating of suitability assessment of material among clients. Reliability test, calculation by formula. descriptive statistics and Fisher exact were used respectively for the statistical analysis with SPSS version 25. ResultsThe mean age of the experts was 41.6±7.2 years and that of maternal child health clients was 30.7±5.4 years for poster, 31.3±5.2 for leaflet and 29.0±5.1 for song. Cronbach alpha reliability coefficient of the translated SAM were; 0.69 for poster, 0.87 for leaflet and 0.20 for song. The Interclass Coefficient (ICC) of all the materials were; leaflet (0.97); poster (0.89); song (0.98) and the internal consistency Cronbach alpha coefficients >0.8. The validity index for the materials were; leaflet (0.94), poster (0.94) and song (1.00). The Item Scale Level Universal Agreement (S-ICVI/UA) was >0.8 for all the materials. Nearly all clients (96%) rated song content as superior. The poster and leaflet were rated as superior by 74% and 68% of clients respectively. Clients rated the content, literacy demand and cultural appropriateness domains as superior regardless of their sociodemographic characteristics. ConclusionThese locally developed education materials for maternal depression have excellent content validity of experts and were highly rated by clients. This process should inform the development of content of other education materials in Africa.
Multivariate Logistic Regression Analysis of the Outcomes After Humeral Head Replacement: A Case Series
Authors: Chen Chunhui , Wang Xingyu , Lin Xubo 
Published: November 2020

Abstract
Background: The aim of our study was to explore the risk factors affecting the treatment of humeral head replacement. Methods: 52 patients with humeral head replacement surgery were enrolled in the study. The information of patients were recorded. The treatment outcomes of humeral head replacement were evaluated by ASES scores. The indicators that may affect humeral head arthroplasty surgery effect were analyzed by univariate analysis and multivariate logistic regression analysis. Results: Univariate analysis showed: the differences of age, time from injury to surgery, time to start exercising after surgery, whether the patient regular follow-up, visual Analogue Scale(VSA), whether with shoulder dislocation, and whether with osteoporosis, were statistically significant (P <0.05). Multivariate Logistic regression analysis showed that age, time from injury to surgery, whether with shoulder dislocation, time to start exercising after surgery, and whether the patient regular follow-up were the influencing factors, but whether with osteoporosis and VSA were not illustrated as a risk factor. Conclusion: Age, time from injury to surgery, time to start exercising after surgery, whether with shoulder dislocation, and whether the patient regular follow-up may be the chief factors affecting humeral head replacement surgery. Trial Registration: This trial was registered at the Research Registry on June 22, 2018(researchregistry3243, https://www.researchregistry.com/browse-the-registry).
Association of Menopausal Status with COVID-19 Outcomes: A Propensity Score-Matching Analysis
Authors: Wang Xing-Wang , Hu Hao , Xu Zhi-Yong , Zhang Gong-Kai , Yu Qing-Hua , Yang Hui-Lan , Zheng Ji-Hua 
Published: November 2020

Abstract
Background: Despite the growing number of studies on the Coronavirus Disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes.Materials and methods: In this retrospective study, we included 336 COVID-19 in-patients between February 15, 2020 and April 30, 2020 at the Taikang Tongji Hospital (Wuhan), China. Electronic medical records, including patient demographics, laboratory results, and chest computed tomography (CT) images were reviewed. Results: In total, 300 patients with complete clinical outcomes were included for analysis. The mean age was 65.3 years and most patients were women (n=167, 55.7%). Over 50% of patients presented with comorbidities, with hypertension (63.5%) being the most common comorbidity. After propensity-score matching, results showed that men had significantly higher odds than premenopausal women for developing severe disease type (23.7% vs. 0%, OR 17.12, 95% CI 1.00–293.60; p=0.003) and bilateral lung infiltration (86.1% vs. 64.7%, OR 3.39, 95% CI 1.08–10.64; p= 0.04), but not for mortality (2.0% vs. 0%, OR 0.88, 95% CI 0.04–19.12, p=1.00). However, non-significant difference was observed among men and post-menopause women in the percentage of severe disease type (32.7% vs. 41.7%, OR 0.68, 95% CI 0.37–1.24, p=0.21) and bilateral lung infiltration (86.1% vs. 91.7%, OR 0.56, 95% CI 0.22–1.47, p=0.24), mortality (2.0% vs. 6.0%, OR 0.32, 95% CI 0.06–1.69, p=0.25).Conclusions: Men had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor-prognosis of postmenopausal women in clinical practice.
Picomolar Binding Selective Human Ron Inhibitory Antibodies Directed to Surface Displayed Conformational Epitopes for Imaging and Therapy&nbsp;&nbsp;
Authors: Koh Xin Yu , Koh Xiao Hui , Spiegelberg Diana , Jha Preeti , Nestor Marika , Hwang Le-ann , Tan Ban Xiong , Lane David 
Published: November 2020

Abstract
BackgroundThe RON protein is an exceptionally interesting target in oncology and immunology. It is not only overexpressed in a wide variety of tumors but also has been shown to be expressed on myeloid cells associated with tumor infiltration, where it serves to dampen tumour immune response and reduce the efficacy of anti-CTLA4 therapy. Potent and selective inhibitory antibodies to RON might therefore both inhibit tumor cell growth and stimulate immune rejection of tumors. MethodsWe derived a new panel of exceptionally avid anti-RON antibodies with using traditional hybridoma technologies with picomolar binding affinities that inhibit MSP-induced RON signaling and show remarkable potency in antibody dependent cellular cytotoxicity (ADCC). ResultsWhen radiolabeled with 89-Zirconium, the new antibodies 3F8 and 10G1 also allow effective immuno-positron emission tomography (immunoPET) imaging of RON-expressing tumors and recognize universally exposed RON epitopes at the cell surface. Conclusion In addition to their development as anti-RON cancer therapeutics, the new antibodies have great potential to be developed for tracking RON expressing tumours and metastases in cancer patients as diagnostic PET imaging agents, either as whole IgG or as a minibody.
Integrated Bioinformatics Analysis Reveals Potential Mechanisms Associated with Intestinal Flora Intervention in Non-alcoholic Fatty Liver Disease
Authors: Liu Yingying , Liu Xinkui , Zhou Wei , Zhang Jingyuan , Guo Siyu , Jia Shanshan , Wu Jiarui , Wang Haojia , Li Jialin , Tan Yingying 
Published: November 2020

Abstract
Background

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that imposes a huge economic burden on global public health. And the gut-liver axis theory supports the therapeutic role of intestinal flora in the development and progression of NAFLD. To this end, we designed bioinformatics study on the relationship between intestinal flora disorder and NAFLD, so as to explore the molecular mechanism of intestinal flora interfering with NAFLD.
Methods

Differentially expressed genes for NAFLD were obtained from GEO database. And the disease genes for NAFLD and intestinal flora disorder were obtained from the disease databases. Using string 11.0 database to establish protein-protein interaction network relationship and cytoscape 3.7.2 software visualization. Cytoscape plug-in MCODE and cytoHubba were used to screen the potential genes of intestinal flora disorder and NAFLD, so as to obtain potential targets for intestinal flora to interfere in the occurrence and process of NAFLD. Enrichment analysis of potential targets was carried out using R 4.0.2 software.
Results

The results showed that PTGS2, SPINK1 and C5AR1 may be the key genes for intestinal flora to interfere with NAFLD. CCL2, IL6, IL1B and FOS may be key genes for the development and progression of NAFLD. The gene function is mainly reflected in basic biological processes, including the regulation of metabolic process, epithelial development and immune influence. The pathway is mainly related to signal transduction, immune regulation and physiological metabolism. The TNF signaling pathway, AGE-RAGE signaling pathway in the diabetic activity, and NF-Kappa B signaling pathways are important pathways for intestinal flora to interfere with NAFLD.
Conclusion

According to the analysis results, there is a certain correlation between intestinal flora disorder and NAFLD. It is speculated that the mechanism by which intestinal flora may interfere with the occurrence and development of NAFLD is mainly related to inflammatory response and insulin resistance. Nevertheless, further research is needed to explore the specific molecular mechanisms.
Impact of Physical Activity and Type of Cooking Oil Amongst Diabetes With Co-existing Hypertension Patients on Length of Stay and Cost: General Linear Model
Authors: Sharma Amit , Baldi Ashish , Sharma Dinesh Kumar 
Published: November 2020

Abstract
Background: Diabetes mellitus with co-existing hypertension contributes to increased morbidity and mortality. The study aimed to investigate the impact of the patients' physical activity status and the type of cooking oil consumed by patients in their daily routine on glycemic profile, lipid profile, the hypertensive profile of the patients, and the length of stay and overall cost of the treatment.Methods: A prospective observational study. All the patients who referred to the medicine department of the three different hospitals located in Moga, City Punjab and those who were hospitalized due to diabetes mellitus (type-I and type-II) with co-existing hypertension were asked to participate in the study.Results: The patients' mean age was found to be M= 53.85, SD= 11.54 years. Out of 1914 patients, 914 were male (47.8%); it was observed that the majority of the patients 525 (27.43%) in North India using butter or ghee- clarified butter as edible oil, followed by mustard oil 517 (27.01%) patients. About 345 (18.03%) of the patients consume soybean oil, whereas 226 (11.81%) of the patients like sunflower oil. Discussion: This study explored that cooking oil and physical activity are associated with length of stay in days & overall cost of the treatment, respectively. Our study results revealed that the type of oil compared with the treatment's overall cost was significant for olive oil, soybean oil, and groundnut oil.Conclusion: The study revealed that moderate and low physical activity increases the length of stay compared to high physical activity. The consumption of olive oil as a regular food habit in daily routine decreases patients' length of stay with diabetes with coexisting hypertension when doing high physical activity but increases the overall cost of treatment.