bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy BIM: the feasibility of integrating architecture health indicators using a building information model (BIM) computer system
Authors: Rice Louis 
Published: December 2020

PurposeThe COVID-19 pandemic has forced billions of people into lockdown; foregrounding the important relationship between architecture and health. In this context, there is heightened urgency for the construction sector to improve the healthiness of buildings. Accordingly, the research identifies the feasibility of measuring various building health indicators (BHIs) through the use of a building information management (BIM) model. The research seeks to find optimal strategies for integrating the near ubiquitous use of BIM with a range of health indicators related to building design.Design/methodology/approachA systematic literature review was undertaken to identify potential BHIs for use in BIM models. The research then undertook a Delphi technique in order to test the hypothesis. In total, three rounds of questionnaire-based surveys were undertaken with expert participants.FindingsThe research identifies three different levels of BIM complexity in order to achieve the integration of health indicators. The most simple strategy suggests BHI can be directly measured using existing BIM models; the next level of sophistication requires “plug-in” software to BIM models; the final level would require additional sensors and detectors in a “smart” building.Practical implicationsThe research is significant for users of BIM, building designers, public health advisors, construction professionals, healthcare providers, social prescribers, architects and clients.Originality/valueThe integration of BHI into the architectural design process is an important step towards the construction sector improving health and well-being. The research provides for the first time a rigorous identification of the most viable mechanisms through which BIM may be used to measure the healthiness of a building.
Maintenance management of heritage buildings in Iraq
Authors: Kashkool Afrah Mohammed Hasan , Al Ali Saba Sami 
Published: December 2020

PurposeHeritage buildings, as any other buildings are subject to decay and deterioration. This issue increases significantly when a country undergoes complicated circumstances of unrest, as is the case in Iraq. The purpose of this study is to rethink the maintenance approach to heritage buildings in Iraq from a systematic management standpoint. It proposes the development of a management system through the functions of proper planning, organizing, directing and controlling. The study aims to scrutinize the weak areas of performance in the investigated work process in Iraq and provide suggestions to address them.Design/methodology/approachThe paper opted for an exploratory study, using interviews with responsible people in Iraqi heritage buildings administration to investigate the procedures applied on maintenance work for the heritage buildings. Besides, maintenance reports were reviewed and three case studies of buildings recently assigned for maintenance were visited and examined to identify the current course of actions at work and to uncover the points of weakness and strength.FindingsThe researchers identified a kind of unreal planning in the maintenance process, which appeared to be a manifestation of corrective maintenance (CM) rather than a preventive one. Such an aspect was highlighted due to several causes, among which most important were as follow (1) the lack of sufficient allocated budgets and (2) the shortage of hand labor and building technicians in this field, including professionals with an architectural training background, who could make practical choices to heritage maintenance thus preventing improper solutions that would harm the authenticity of the asset. Such factors could be mitigated if a good maintenance management system is to be adopted. A proposed system is hereby suggested, upgrading the current guideline and laws by the specialized authorities in addition to recommending the application of digital documentation.Originality/valueThis paper fulfills an identified need to study how maintenance management system can be applied for heritage buildings
An investigation of the consumer’s trusting mechanism in emerging healthcare technology
Authors: Wei Xinyu , Xie Heng , Peng Xianghui , Prybutok Victor 
Published: December 2020

PurposeThe purpose of this research is to investigate how the consumer’s trusting mechanism influences their behavioral adoption intention in the context of genetic testing.Design/methodology/approachBased on the technology acceptance theory and trust formation theory, the research posits and develops a comprehensive trust model by integrating trust-related factors that correlate to the consumer’s trusting beliefs and trusting intention. Survey data with 525 respondents allow to test and validate the model.FindingsThe tested model shows that technology institutional trust base, end-user’s cognitive trust base and social influence are significant determinants of trusting beliefs. The findings also reveal that mediation effects of performance expectancy and perceived risks exist in the relationship between trusting beliefs and trusting intention.Originality/valueThe foreseeable positive impact and rapid market growth of emerging healthcare technologies necessitate the strong need to study user acceptance. However, there is a lack of research on how consumers trust and their adoption intention of such innovations. Prior empirical evidence from different contexts and perspectives also show contradictory findings. This research extends the existing technology acceptance literature to a healthcare context, provides an improved generalized understanding of the consumer’s trusting mechanism in emerging biotechnology and discusses practical insights for regulatory authorities, healthcare institutes and medical professionals.
Appropriate polypharmacy: a barometer for integrated care
Authors: Mair Alpana , Antoniadou Eleftheria , Hendry Anne , Gabrovec Branko 
Published: December 2020

PurposePolypharmacy, the concurrent use of multiple medicines by one individual, is a common and growing challenge driven by an ageing population and the growing number of people living longer with chronic conditions. Up to 11% of unplanned hospital admissions in the UK are attributable to, mostly avoidable, harm from medicines. However, this topic is not yet central to integrated practice. This paper reviews the challenge that polypharmacy presents to the health and care system and offers lessons for integrated policy and practice.Design/methodology/approachTwo commonly encountered scenarios illustrate the relevance of addressing inappropriate polypharmacy to integrated practice. An overview of the literature on polypharmacy and frailty, including two recent large studies of policy and practice in Europe, identifies lessons for practitioners, managers, policy makers and commissioners.FindingsComprehensive change strategies should extend beyond pharmacist led deprescribing initiatives. An inter-professional and systems thinking approach is required, so all members of the integrated team can play their part in realising the value of holistic prescribing, appropriate polypharmacy and shared decision making.Practical implicationsAwareness and education about polypharmacy should be embedded in inter-professional training for all practitioners who care for people with multimorbidity or frailty.Originality/valueThis paper will help policy makers, commissioners, managers and practitioners understand the value of addressing polypharmacy within their integrated services. Best practice national guidance developed in Scotland illustrates how to target resources so those at greatest risk of harm from polypharmacy can benefit from effective pharmaceutical care as part of holistic integrated care.
Does arts engagement and cultural participation impact depression outcomes in adults: a narrative descriptive systematic review of observational studies
Authors: Elsden Esme , Roe Brenda 
Published: December 2020

Purpose
The purpose of this study is to explore whether engaging with arts and culture affect depression in adults. This is because depression is the most common mental health disorder. Diversification of mental health services, initiatives in arts in health and social prescribing are providing emerging evidence of benefits relating to depression outcomes.

Design/methodology/approach
A systematic review design adhering to the preferred reporting items for systematic reviews and meta-analyses reporting guidelines. MEDLINE®, Embase and American psychology association PsycINFO were searched and six studies were deemed eligible. Data extraction and quality appraisal enabled a narrative descriptive summary comparing study design, characteristics, populations and key results relating arts and cultural engagement to depression outcomes.

Findings
The total number of participants across the studies were 49,197. Three studies reported mean age, 58.78 years (15–99 years). Gender reported by five studies was 52.4% (n = 24,689) female and 47.6% (n = 22,439) male. Five studies found that engaging with arts decreased your odds of having depression.

Originality/value
This systematic review found emerging evidence that arts and cultural engagement benefits a wider population by reducing depression incidence. Establishing and understanding the association between arts engagement and decreasing depression incidence in a population is relevant to health-care providers, the general population and policymakers alike.
A review of the trend of microlearning
Authors: Leong Kelvin , Sung Anna , Au David , Blanchard Claire 
Published: December 2020

PurposeMicrolearning has been considered as a promising topic in work-based learning. This paper aims to review the trends of microlearning in terms of related publications and Internet searches. Hopefully, the findings can serve as a reference for the education sector, government, business and academia to promote, design and use microlearning.Design/methodology/approachIn this study, two sets of analysis were conducted. Firstly, the authors analysed the publication trend of microlearning. Second, the authors analysed the trend of Internet searches related to microlearning. More specifically, the authors analysed real-world data of 14 years obtained from Scopus and Google Trends for the purpose. These data include the first relevant publication found in the database.FindingsIn total, 476 relevant publications have been identified during 2006–2019. According to the findings from the analysis of the identified publications, microlearning is a relevantly new and emerging global topic involving authors, affiliations and funding sponsors from different countries. Moreover, many microlearning-related publications were conducted from perspectives of e-learning or mobile learning. Furthermore, the authors notice higher education was the most frequently mentioned education level in the identified publications. On the other hand, language learning (i.e. second language, vocabulary learning, etc.) had been mentioned more times in the titles and abstracts than other subject areas. Overall, the increasing trend of publications on “microlearning” (as a knowledge supply) is in line with the established increasing Internet searches of “microlearning” (as a practical demand) in recent years.Practical implicationsFrom the work-based learning perspective, microlearning has been considered as one of the key topics in talent development topics. Policymakers, educators, researchers and participators have the responsibility to explore how to promote, design and use microlearning to help people to learn in the right direction through valid knowledge with ethical consideration.Originality/valueAlthough many works had been done on microlearning, there is a lack of comprehensive studies reviewing the trends of microlearning in terms of related publications and Internet searches. This study aims to fill this gap by analysing real-world data obtained from Scopus and Google Trends – these data include the first relevant publication found in the database. The authors believe this is the first time that a study has been conducted to comprehensively review the development trends of microlearning. Hopefully, this study can shed some light on related research.
Citrate utilization under anaerobic environment in Escherichia coli is under direct control of Fnr and indirect control of ArcA and Fnr via CitA‐CitB system
Authors: Jiang Fengwei , Huang Xinxin , Barbieri Nicolle L. , Logue Catherine M. , Nolan Lisa K. , Li Ganwu 
Published: December 2020

SummaryMost Escherichia coli (E. coli) strains do not cause disease, naturally living in the lower intestine and is expelled into the environment within faecal matter. Escherichia coli can utilize citrate under anaerobic conditions but not aerobic conditions. However, the underlying regulatory mechanisms are poorly understood. In this study, we explored regulatory mechanisms of citrate fermentation genes by global regulators ArcA and Fnr under anaerobic conditions. A gel mobility shift assay showed that the regulator proteins ArcA and Fnr binded to the promoter region localized between the citAB and citCDEFXGT operons. Subsequent assays confirmed that ArcA indirectly controled the expression of citrate fermentation genes via regulating CitA‐CitB system, while Fnr directly regulated but also indirectly modulated citrate fermentation genes via controling CitA‐CitB system. Deletions of arcA and fnr significantly reduced the growth of Escherichia coli in M9 medium with a citrate carbon source. We conclude that both ArcA and Fnr can indirectly control the citrate utilization via CitA‐CitB system, while Fnr can also directly regulate the expression of citrate fermentation genes in E. coli under anaerobic conditions.
Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau
Authors: Qian‐Qian Zhang , Sheng‐Long Jian , Ke‐Mao Li , Zhen‐Bing Wu , Hong‐Tao Guan , Jin‐Wen Hao , Shu‐Yi Wang , Yao‐Yao Lin , Guo‐Jie Wang , Ai‐Hua Li 
Published: December 2020

SummaryPlanktonic microorganisms play a key role in the biogeochemical processes of the aquatic system, and they may be affected by many factors. High‐throughput sequencing technology was used in this study to investigate and study the bacterioplankton community of water bodies in the upper reaches of the Heihe River Basin in Qinghai Plateau. Results showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria are the predominant phyla in this river section, while the main genera are Thiomonas, Acidibacillus, Acidocella, Rhodanobacter, Acidithiobacter and Gallionella, which are autochthonous in the acid‐mine drainage. Additionally, total nitrogen, total phosphorus, permanganate index and pH are significantly correlated with the bacterioplankton abundance and are the main limiting factors for the spatial distribution of the bacterioplankton. PICRUSt inferred that the mainstream microbial assemblages had a higher abundance of KOs belong to metabolism of terpenoids and polyketides, while the tributary had higher abundance of KOs belong to the immune system. The relationship between bacterioplankton community composition and environmental factors in the Heihe River basin was discussed for the first time in this study, which provides a theoretical basis for the healthy, orderly development of the water environment in the Heihe River Basin.
Wide distribution of Phycisphaera‐like planctomycetes from WD2101 soil group in peatlands and genome analysis of the first cultivated representative
Authors: Dedysh Svetlana N. , Beletsky Alexey V. , Ivanova Anastasia A. , Kulichevskaya Irina S. , Suzina Natalia E. , Philippov Dmitriy A. , Rakitin Andrey L. , Mardanov Andrey V. , Ravin Nikolai V. 
Published: December 2020

SummaryPhycisphaera‐like WD2101 ‘soil group’ is one of the as‐yet‐uncultivated phylogenetic clades within the phylum Planctomycetes. Members of this clade are commonly detected in various terrestrial habitats. This study shows that WD2101 represented one of the major planctomycete groups in 10 boreal peatlands, comprising up to 76% and 36% of all Planctomycetes‐affiliated 16S rRNA gene reads in raised bogs and eutrophic fens respectively. These types of peatlands displayed clearly distinct intra‐group diversity of WD2101‐affiliated planctomycetes. The first isolate of this enigmatic planctomycete group, strain M1803, was obtained from a humic lake surrounded by Sphagnum peat bogs. Strain M1803 displayed 89.2% 16S rRNA gene similarity to Tepidisphaera mucosa and was represented by motile cocci that divided by binary fission and grew under micro‐oxic conditions. The complete 7.19 Mb genome of strain M1803 contained an array of genes encoding Planctomycetal type bacterial microcompartment organelle likely involved in l‐rhamnose metabolism, suggesting participation of M1803‐like planctomycetes in polysaccharide degradation in peatlands. The corresponding cellular microcompartments were revealed in ultrathin cell sections. Strain M1803 was classified as a novel genus and species, Humisphaera borealis gen. nov., sp. nov., affiliated with the formerly recognized WD2101 ‘soil group’.
Biotechnological approaches for the production of designer cheese with improved functionality
Authors: Chourasia Rounak , Abedin Md Minhajul , Chiring Phukon Loreni , Sahoo Dinabandhu , Singh Sudhir P. , Rai Amit Kumar 
Published: December 2020

AbstractCheese is a product of ancient biotechnological practices, which has been revolutionized as a functional food product in many parts of the world. Bioactive compounds, such as peptides, polysaccharides, and fatty acids, have been identified in traditional cheese products, which demonstrate functional properties such as antihypertensive, antioxidant, immunomodulation, antidiabetic, and anticancer activities. Besides, cheese‐making probiotic lactic acid bacteria (LAB) exert a positive impact on gut health, aiding in digestion, and improved nutrient absorption. Advancement in biotechnological research revealed the potential of metabolite production with prebiotics and bioactive functions in several strains of LAB, yeast, and filamentous fungi. The application of specific biocatalyst producing microbial strains enhances nutraceutical value, resulting in designer cheese products with multifarious health beneficial effects. This review summarizes the biotechnological approaches applied in designing cheese products with improved functional properties.
Harvesting of Onion Grass, Romulea rosea L. by Sulphur‐crested Cockatoo, Cacatua galerita Latham
Authors: Moore Gregory M. 
Published: December 2020

SummaryThe harvesting of Onion Grass (Romulea rosea) corms by flocks of Sulphur‐crested Cockatoo (Cacatua galerita) is well known. Individual birds and large flocks feed on the weed in pastures, grasslands and recreational turf. Flocks of Sulphur‐crested Cockatoo were observed feeding on Onion Grass at seven sites along the Maribyrnong River at Keilor, Victoria. Flock size and feeding habits were noted, as were the depth of corms, the time taken to remove corms from the ground and the number of eaten and lifted but uneaten corms. From the data collected, it was estimated that an individual bird can extract and eat about 200 plants per hour and that even a small flock can consume several thousand plants in a feeding session. Corms were typically within 20 mm of the soil surface and were removed primarily by the cockatoo with its beak, but the left foot was sometimes used to excavate the corm from the soil. Flock feeding sessions lasted from about 0.5 to 2.5 hours, but feeding by individual or pairs of birds was often shorter. Plants that had been removed from the soil appeared to have intact corms, but all that was left were the outer scales. Of the plants removed from the soil, only 6% had intact corms attached. The removal of large numbers of Onion Grass plants could impact on their population numbers over time if there was repeated annual harvesting.
Brown−Vialetto−Van Laere and Fazio−Londe syndromes: SLC52A3 mutations with puzzling phenotypes and inheritance
Authors: Gayathri Santhalingam , Gowda Vykuntaraju K. , Udhayabanu Tamilarasan , O'Callaghan Benjamin , Efthymiou Stephanie , Varalakshmi Perumal , Benakappa Naveen , Houlden Henry , Ashokkumar Balasubramaniem 
Published: December 2020

AbstractBackgroundBrown−Vialetto−Van Laere syndrome (BVVLS) and Fazio−Londe disease (FLD) are rare neurological disorders presenting with pontobulbar palsy, muscle weakness and respiratory insufficiency. Mutations in SLC52A2 (hRFVT‐2) or SLC52A3 (hRFVT‐3) genes can be responsible for these disorders with an autosomal recessive pattern of inheritance. The aim of this study was to screen for mutations in SLC52A2 and SLC52A3 among Indian families diagnosed with BVVLS and FLD.MethodsSLC52A2 and SLC52A3 were screened in one FLD and three BVVLS patients by exon‐specific amplification using PCR and sequencing. In silico predictions using bioinformatics tools and confocal imaging using HEK‐293 cells were performed to determine the functional impact of identified mutations.ResultsGenetic analysis of a mother and son with BVVLS was identified with a novel homozygous mutation c.710C>T (p.Ala237Val) in SLC52A3. This variant was found to have an autosomal pseudodominant pattern of inheritance, which was neither listed in the Exome Variant Server or in the 1000 Genomes Project database. In silico analysis and confocal imaging of the p.Ala237Val variant showed higher degree of disorderness in hRFVT‐3 that could affect riboflavin transport. Furthermore, a common homozygous mutation c.62A>G (p.Asn21Ser) was identified in other BVVLS and FLD patients. Despite having different clinical phenotypes, both BVVLS and FLD can be attributed to this mutation.ConclusionA rare and peculiar pattern of autosomal pseudodominant inheritance is observed for the first time in two genetically related BVVLS cases with Indian origin and a common mutation c.62A>G (p.Asn21Ser) in SLC52A3 can be responsible for both BVVLS and FLD with variable phenotypes.
Diphenylcyclopropenone plays an effective therapeutic role by up‐regulating the TSLP/OX40L/IL‐13 pathway in severe alopecia areata
Authors: Gong Yugang , Luo Li , Li Ling , He Xun , Lu Wei , Sha Xiaowei , Mao Yujie 
Published: December 2020

AbstractTopical immunotherapy with diphenylcyclopropenone (DPCP) is considered to be the most effective treatment of severe AA. However, the mechanism is unclear and an early predictor for the efficacy needs to be explored. The TSLP/OX40L/IL‐13 pathway is an important pathway to initiate and maintain Th2 immune responses. Our previous work suggests this pathway may play a role in severe AA treated with DPCP. Thus, to further investigate the mechanism of TSLP/OX40L/IL‐13 pathway in severe AA treated with DPCP and explore the predictor for the efficacy of DPCP therapy, we conducted a prospective study to compare expression levels of TSLP, OX40L, Th2 cytokines IL‐4, IL‐5 and IL13, and Th1 cytokine IFN‐γ in severe AA patients before and after the treatment. Results showed that 21 AA patients were responsive (responders) to the DPCP therapy and 12 were not responsive (non‐responders). Responders had lower levels of TSLP, OX40L and IL‐13 than non‐responders before the treatment. After the DPCP treatment, TSLP, IL‐5 and IL‐13 increased and IFN‐γ decreased in responders while there were no changes of TSLP, IL‐4, IL‐13 and IFN‐γ in non‐responders. Our data suggest that the TSLP/OX40L/IL‐13 pathway is down‐regulated in some severe AA patients and DPCP might play a therapeutic role by up‐regulating the pathway in these severe AA patients. The TSLP/OX40L/IL‐13 pathway could be a predictor of response to the DPCP therapy for severe AA patients.