bluuebunny/crossref_metadata_2025_split huggingface dataset:
Part III: Advancing Media-related Educational Competencies
Authors: Tiede Jennifer 
Published: June 2020

In the first part of this dissertation, selected models and standards from Germany and the USA were introduced, based on a literature review and thus revealing what is considered relevant for practice in a variety of sources and which competencies preservice teachers should acquire, according to these sources. In the second part, methods and selected results of competency measurements were introduced, thus demonstrating ways to operationalize the models and to assess the outcomes of respective processes of such a model integration. Complementary to these theoretical and measurement-focused perspectives on media-related educational competencies, it is important to extend the viewpoint to practices of media-related education of preservice teachers: the objectives both of competency models and of competency measurements ultimately include impacting the respective practices in teacher education and offering a grounded basis and stimuli for improvements and enhanced practice. In accordance with this, various sources emphasize the importance of research on the integration of ICT and respective competencies into initial teacher education (Enochsson und Rizza 2009; Krumsvik 2014; Tondeur u. a. 2017).
Art as a Political Act The Russian Agit-Props of the 1920s
Authors: Savaşır Gökçeçiçek , Güleç Ece 
Published: June 2020

Emerged in the mid-19th century, the
mechanical reproduction techniques changed the definitions of work of art,
artist, and the social role of art. These transformations triggered an
extensive socio-cultural revolution during the 20th century. Art turned out to
be an instrument for guiding the masses; and the communist ideology politicized
aesthetics. The Russian Constructivists of the 1920s utilized agitation and
propaganda techniques (agit-props) in their art for creating an aesthetic
language for the political propaganda. This study argues that the Russian
avant-garde aiming to bring art into everyday life and urban space became an
instrument for aestheticization of politics. The scope is limited to the agit-props
appropriated by the Bolshevik power. Dwelling on literary and visual
information from literature, it scrutinizes the topic with a historical
interpretation research method. It aims to discuss the agit-props within the
framework of aesthetics and politics, aesthetic revolution in everyday life and
urban space.
A 1D shallow-flow model for two-layer flows based on FORCE scheme with wet–dry treatment
Authors: Martínez-Aranda S. , Ramos-Pérez A. , García-Navarro P. 
Published: June 2020

Abstract
The two-layer problem is defined as the coexistence of two immiscible fluids, separated by an interface surface. Under the shallow-flow hypothesis, 1D models are based on a four equations system accounting for the mass and momentum conservation in each fluid layer. Mathematically, the system of conservation laws modelling 1D two-layer flows has the important drawback of loss of hyperbolicity, causing that numerical schemes based on the eigenvalues of the Jacobian become unstable. In this work, well-balanced FORCE scheme is proposed for 1D two-layer shallow flows. The FORCE scheme combines the first-order Lax–Friedrichs flux and the second-order Lax–Wendroff flux. The scheme is supplemented with a hydrostatic reconstruction procedure in order to ensure the well-balanced behaviour of the model for steady flows even under wet–dry conditions. Additionally, a method to obtain high-accuracy numerical solutions for two-layer steady flows including friction dissipation is proposed to design reference benchmark tests for model validation. The enhanced FORCE scheme is faced to lake-at-rest benchmarking tests and steady flow cases including friction, demonstrating its well-balanced character. Furthermore, the numerical results obtained for highly unsteady two-layer dambreaks are used to analyse the robustness and accuracy of the model under a wide range of flow conditions.
Comparison of spatial interpolation methods for the estimation of precipitation patterns at different time scales to improve the accuracy of discharge simulations
Authors: Liu Dedi , Zhao Qin , Fu Dezhi , Guo Shenglian , Liu Pan , Zeng Yujie 
Published: June 2020

Abstract
Interpolating precipitation data is of prime importance to hydrological design, modeling, and water resource management. Various models have been developed that estimate spatial precipitation patterns. The purpose of this study is to analyze different precipitation interpolation schemes at different time scales in order to improve the accuracy of discharge simulations. The study was carried out in the upstream area of the Changjiang River basin. The performance of all selected methods was assessed using cross-validation schemes, with the mixed methods ultimately displaying the best performance at all three time scales. However, the differences in performance between the spatial interpolation methods decreased with increasing time scales. The unifying catchment Soil and Water Assessment Tool (SWAT), ‘abcd’, and the Budyko equation were employed at the daily, monthly, and annual scales, respectively, to simulate discharge. The performance of the discharge simulation at the monthly and annual time scales was consistent with their ranks of spatial precipitation estimation. For coarse, or long period, precipitation, there were no significant differences. However, the mixed methods performed better than the single model for the daily, or short, time scale with respect to the accuracy of the discharge simulation.
Assessment for which tide level saltwater intrusion occurs in a sewer network. Case study: Barreiro/Moita WWTP, Portugal
Authors: Figueiredo A. , Amaral L. , Pacheco J. 
Published: June 2020

Abstract
Salt water from the Tagus Estuary has been identified in the influent at Barreiro/Moita Wastewater Treatment Plant (WWTP), Portugal. The saltwater intrusion occurs during high tide levels in the estuary throughout damaged sections and direct vectors in the sewer network, changing the wastewater characteristics impacting the WWTP processes. This work has designed a methodology to assess from which tide level in the Tagus Estuary saltwater intrusion occurs in the sewer network by measuring WWTP influent's electric conductivity (EC). The methodology identifies saltwater intrusion for tide levels higher than 3.10 m, increasing significantly for tide levels higher than 4.00 m. During this study, 86% of the days registered at least one high tide level higher than 3.10 m, and 8% higher than 4.00 m, demonstrating a considerable occurrence of saltwater intrusion in the system with a tendency to increase due to the mean sea level rise registered in the Tagus Estuary. To prevent it, it is necessary to map infrastructures and assess the most critical points.
Advances in Drug Therapy for Systemic Lupus Erythematosus
Authors: Zhao Xinghua , Zhang Jiaojiao , Liang Yutong , Li Jie , Ding Shi , Wang Yang , Chen Ye , Liu Ju 
Published: June 2020

Background:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized
by a local or systemic inflammatory response. At present, the increasing research results show that the
pathogenesis of the disease is complex, and the methods of clinical treatment also show diversity. This
review analyzes and summarizes the existing mechanism research and drug treatment methods in order
to provide a reference value for further drug research and development.

Method:
We carried out a thorough literature search using databases. According to the main purpose of
the article, irrelevant articles were excluded after further examination and directly relevant articles were
included. Finally, the information related to the article was summarized.

Result:
In this article, seventy-four articles are included. According to related articles, there are mainly
four kinds of drugs, namely antimalarial drugs, glucocorticoids, immunosuppressive agents and biological
agents. About fifty-five articles summarized the drugs for the treatment of systemic lupus erythematosus.
The rest of the articles were related to the research progress of the mechanism of systemic lupus
erythematosus.

Conclusion:
This article describes the pathogenesis of systemic lupus erythematosus, and summarizes
the traditional and new therapeutic drugs, which is not only beneficial to the treatment of lupus erythematosus
patients, but also plays a vital reference significance for the future development of new systemic
lupus erythematosus drugs.
Comparative Efficacy and Safety of Duration of Dual Antiplatelet Therapy in Patients with CAD Undergoing Drug-eluting Stent Implantation: A Systematic Review and Network Meta-analysis
Authors: Guan Jieqiong , Song Wenjing , He Pan , Fan Siyu , Zhi Hong , Wang Lina 
Published: June 2020

Objective:
The aim was to evaluate the efficacy and safety of duration of dual antiplatelet therapy
(DAPT) for patients who received percutaneous coronary intervention (PCI) with a drug-eluting stent.

Background:
The optimal duration of DAPT to balance the risk of ischemia and bleeding in CAD patients undergoing
drug-eluting stent (DES) implantation remains controversial.

Methods:
PubMed, Cochrane Library, Web of Science, Clinicaltrials.gov, CNKI and Wanfang Databases were
searched for randomized controlled trials of comparing different durations of DAPT after DES implantation.
Primary outcomes were major adverse cardiac and cerebrovascular events (MACCE), and major bleeding, and
were pooled by Bayes network meta-analysis. Net adverse clinical and cerebral events were used to estimate the
surface under the cumulative ranking (SUCRA) curves. The subgroup analysis based on clinical status, follow-up
and area was conducted using traditional pairwise meta-analysis.

Results:
A total of nineteen trials (n=51,035) were included, involving six duration strategies. The network metaanalysis
showed that T2 (<6-month DAPT followed by aspirin, HR:1.51, 95%CI:1.02-2.22), T3 (standard
6-month DAPT, HR:1.47, 95%CI:1.14-1.91), T4 (standard 12-month DAPT, HR:1.41, 95%CI:1.15-1.75) and T5
(18-24 months DAPT, HR:1.47, 95%CI:1.09-1.97) was associated with significantly increased risk of MACCE
compared to T6 (>24-month DAPT). However, no significant difference was found in MACCE risk between T1
(<6-month DAPT followed by P2Y12 monotherapy) and T6. Moreover, T5 was associated with significantly
increased risk of bleeding compared to T1(RR:3.94, 95%CI:1.66-10.60), T2(RR:3.65, 95%CI:1.32-9.97),
T3(RR:1.93, 95%CI:1.21-3.50) and T4(RR:1.89, 95%CI:1.15-3.30). The cumulative probabilities showed that
T6(85.0%), T1(78.3%) and T4(44.5%) were the most efficacious treatment compared to the other durations. In
the ACS (<50%) subgroup, T1 was observed to significantly reduce the risk of major bleeding compared to T4,
but not in the ACS (≥50%) subgroup.

Conclusions:
Compared with other durations, short DAPT followed by P2Y12 inhibitor monotherapy showed
non-inferiority, with a lower risk of bleeding and not associated with an increased MACCE. In addition, the risk
of major bleeding increased significantly, starting with DAPT for 18-month. Compared with the short-term treatment,
patients with ACS with the standard 12-month treatment have a better prognosis, including lower bleeding
rate and the decreased risk of MACCE. Due to study's limitations, the results should be verified in different risk
populations.
Accuracy of Telephone-Based Cognitive Screening Tests: Systematic Review and Meta-Analysis
Authors: Elliott Emma , Green Claire , Llewellyn David J. , Quinn Terence J. 
Published: June 2020

Background:
Telephone-based cognitive assessments may be preferable to in-person testing
in terms of test burden, economic and opportunity cost.

Objective:
We sought to determine the accuracy of telephone-based screening for the identification of
dementia or Mild Cognitive Impairment (MCI).

Methods:
Five multidisciplinary databases were searched. Two researchers independently screened articles
and extracted data. Eligible studies compared any multi-domain telephone-based assessment of
cognition to the face-to-face diagnostic evaluation. Where data allowed, we pooled test accuracy metrics
using the bivariate approach.

Results:
From 11,732 titles, 34 papers were included, describing 15 different tests. There was variation
in test scoring and quality of included studies. Pooled analyses of accuracy for dementia: Telephone Interview
for Cognitive Status (TICS) (<31/41) sensitivity: 0.92, specificity: 0.66 (6 studies); TICSmodified
(<28/50) sensitivity: 0.91, specificity: 0.91 (3 studies). For MCI: TICS-modified (<33/50) sensitivity:
0.82, specificity: 0.87 (3 studies); Telephone-Montreal Cognitive Assessment (<18/22) sensitivity:
0.98, specificity: 0.69 (2 studies).

Conclusion:
There is limited diagnostic accuracy evidence for the many telephonic cognitive screens
that exist. The TICS and TICS-m have the greatest supporting evidence; their test accuracy profiles
make them suitable as initial cognitive screens where face to face assessment is not possible.
Identification and Characterization of Lipopeptide Biosurfactant Producing Microbacterium sp Isolated from Brackish River Water
Authors: Nayarisseri Anuraj , Khandelwal Ravina , Singh Sanjeev Kumar 
Published: June 2020

Background:
Bioremediation has taken its call for removing pollutants for years. The oilcontaminated
surroundings are majorly hazardous for sustaining life, but a great contribution to nature in
the form of microorganisms. The complex carbon-hydrogen chain has served as classic raw material to
chemical industries, which has perked up the hydrocarbon waste. Microbial remediation has been thus,
focused to deal with the lacuna, where the new addition to this category is Microbacterium species.

Objectives:
The identification and characterization of lipopeptide biosurfactant producing Microbacterium
spp. isolated from brackish river water.

Methods:
The strain was isolated from an oil-contaminated lake. The strain was tested with all the other
isolated species for oil degradation using screening protocols such as haemolysis, oil spread assay,
BATH, E24, etc. The produced biosurfactant was extracted by acid precipitation, followed by solvent
recovery. The strain with maximum potential was sequenced and was subjected to phylogeny assessment
using in silico tools.

Results:
Novel Microbacterium species produce the extracellular biosurfactant. The surface tension of
Microbacterium was found to be 32mN/m, indicates its powerful surface tension-reducing property. The
strain was optimized for the production of biosurfactant and the best results were obtained with sucrose
(2%) and yeast extract (3%) medium at 7 pH and 40°C temperature.

Conclusion:
The isolate was confirmed to be a novel Microbacterium species that could produce 0.461
gm biosurfactant in 100 ml of the medium throughout a life cycle and novel strain of isolate was deposited
to NCBI as Microbacterium spp. ANSKSLAB01 using an accession number: KU179507.
Vitamin D among Patients of Pulmonary and Extrapulmonary Tuberculosis: A Prospective Case-control Study
Authors: Gadallah Doaa , Sedky Ahmed , Esmaeel Hend Mohamed 
Published: June 2020

Background:
Vitamin D has an essential role in enhancing the immune system to fight
and destroy bacteria. People with vitamin D deficiency are highly liable to develop active pulmonary
and extrapulmonary tuberculosis.

Objective:
: To evaluate the serum level of vitamin D among patients with pulmonary and
extrapulmonary tuberculosis.

Patients and Methods:
A case-control prospective study was conducted among patients with
pulmonary and extrapulmonary tuberculosis and asymptomatic persons (controls). The study
included 80 participants, 50 were TB patients, while 30 were controls. Vitamin D 1, 25(OH) assay
was done for all.

Results:
Vitamin D assay of the included subjects revealed that 52 patients were vitamin D deficient,
7 patients had insufficient vitamin D and 21 had normal serum levels. Of the extrapulmonary TB
patients, 35 (100%) had vitamin D deficiency, in pulmonary TB patients, 15 (100%) were vitamin D
deficient. While 2 study subjects (6.7%) in the control group were deficient of vitamin D, 7 (23.3%)
had insufficient vitamin D and 21cases had normal vitamin D levels. There was a statistically
significant relationship between pulmonary and extrapulmonary TB cases and vitamin D deficiency
(P< 0.001).

Conclusion:
Vitamin D deficiency was found among pulmonary and extrapulmonary tuberculosis
patients especially among female patients and patients in rural residence. The current study needs
additional work to evaluate the value of adding vitamin D to the TB treatment regimen.
Asthma-COPD Overlap (ACO) among Adult-onset Asthma Patients
Authors: Maranatha Daniel , Amin Nurkristi Permatasari 
Published: June 2020

Background:
Asthma and asthma-COPD overlap (ACO) are heterogeneous airway
obstruction. This study aims to differentiate ACO and adult-onset asthma based on pulmonary
function tests, smoking history, and atopic status.

Methods:
This cross-sectional study of adult-onset asthma evaluated characteristics, such as
bronchodilator reversibility test, the skin prick test, total serum IgE, and serum IL-13 levels of
asthma patients who were current/former smokers with a smoking history of <10 packs-year and ≥10
packs-year and who also had taken FEV1 / FVC <0.7 post-bronchodilator.

Results:
The data of 30 subjects were analyzed and divided into two groups (23 asthma and 7 ACO
subjects). The ACO patients were older compared to asthma patients (63.4 ± 4.7 vs. 53.7 ± 7.7, p =
0.004). A higher percentage of men was found in ACO than in asthma (85.7% vs. 21.7%, p = 0.004).
There was a difference in the cumulative number of cigarettes consumed in patients with ACO and
asthma (19.4 ± 6.4 vs. 7.2 ± 2.6, p = 0.014). The ratio of FEV1 / FVC post-bronchodilator in ACO
patients was significantly lower than in asthma patients (57.3 ± 6.9 vs. 65.5 ± 8.8, p = 0.033). There
was no difference in the duration of the disease between ACO and asthma (7.2 ± 6.1 vs. 6.1 ± 5.5, p =
0.535).

Conclusion:
Differences were seen in the number of cigarettes consumed and the ratio of FEV1/FVC
in ACO and adult-onset asthma patients. The cumulative number of cigarettes consumed could be a
distinguishing characteristic between ACO and asthma.
Vemurafenib Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Disproportionality Analysis in FAERS Database
Authors: Neha Reddy , Beulah Elsa , Anusha Bellapu , Vasista Sharma , Stephy Chacko , Subeesh Viswam 
Published: June 2020

Background:
Signal strength for any drug-event combination can be determined using
disproportionality analysis. Vemurafenib is a BRAF inhibitor approved by the US Food and Drug
Administration (FDA) in 2011 for the treatment of metastatic melanoma. This study aims to identify
the signal strength of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) associated
with vemurafenib using disproportionality analysis in FDA database of Adverse Event Reporting
System (FAERS).

Methods:
Data were obtained from the public release of data in FAERS. Case/non-case method was adopted for the analysis
of association between vemurafenib use and DRESS. The data mining algorithm used for the analysis was Reporting Odds
Ratio (ROR) and Proportional Reporting Ratio (PRR). A value of ROR-1.96SE>1, PRR≥2 were considered as positive
signal strength.

Results:
A total of 7,171 reports for DRESS have been reported in the FDA database. Amongst which 125 reports were
associated with vemurafenib. A cumulative ROR of 17.72 (95% CI 14.83; 21.18) and PRR of 17.46 (95% CI 14.65; 20.81)
were observed. Combination treatment of vemurafenib with cobimetinib had higher number of reports (100) with ROR of
103.42 (84.13- 127.14) and PRR of 94.52 (78.26- 114.15). Four deaths were reported and the non-death serious reports
included hospitalization, life-threatening, disability, and other serious events with 61, 11, 2 and 39 reports respectively.

Conclusion:
Positive signal strength was observed for vemurafenib associated DRESS. The signal strength was higher for
vemurafenib in combination with cobimetinib than vemurafenib alone. Health care professionals should be cautious about
encountering serious adverse events and should be reported to the regulatory authorities.
Activity of Some Novel Chalcone Substituted 9-anilinoacridines against Coronavirus (COVID-19): A Computational Approach
Authors: Kalirajan Rajagopal 
Published: June 2020

Background:
In the year earlier part of 2020, many scientists urged to discover novel drugs
against for the treatments of COVID-19. Coronavirus Disease 2019 (COVID-19), a life-threatening viral
disease, was discovered first in China and quickly spread throughout the world. Objective: In the present
article, some novel chalcone substituted 9-anilinoacridines (1a-z) were developed by in silico studies for
their COVID19 inhibitory activity. Molecular docking studies of the ligands 1a-z were performed
against COVID19 (PDB id - 5R82) targeting the coronavirus using Schrodinger suite 2019-4.

Methods:
The molecular docking studies were performed by the Glide module and the binding energy
of ligands was calculated using the PRIME MM-GB/SA module of Schrodinger suite 2019-4.

Results:
From the results, many compounds are significantly active against COVID19 with a Glide
score of more than -5.6 when compared to the currently used drug for the treatment of COVID19, Hydroxychloroquine
(-5.47). The docking results of the compounds exhibited similar mode of interactions
with COVID19 and the residues, THR25, THR26, LEU27, SER46, MET49, HIE41, GLN189, ARG188,
ASP187, VAL186, HIE164, ASN142, and GLY143 play a crucial role in binding with ligands. MMGBSA
binding calculations of the most potent inhibitors are more stably favourable.

Conclusion:
From the results of in-silico studies, it provides strong evidence for the consideration of
valuable ligands in chalcone substituted 9-anilinoacridines as potential COVID19 inhibitors and the
compounds, 1x,a,r,s with significant Glide scores may produce significant COVID19 activity for further
development, which may prove their therapeutic potential.
WELLNESS TOURISM IN UBUD. “A QUALITATIVE APPROACH TO STUDY THE ASPECTS OF WELLNESS TOURISM DEVELOPMENT”
Authors: Meikassandra Prilicia , Prabawa I Wayan Sukma Winarya , Mertha I Wayan 
Published: June 2020

This study aims to describe the aspects of wellness tourism development in Ubud. Adopted from Corbin theory (2006) which states the body, mind and spirit as part of the five dimensions of wellness, namely physical wellness, emotional wellness, social wellness, intellectual wellness, and spiritual wellness, authors would therefore to identify product wellness, wellness activities, wellness dimension and life cycle of development of wellness tourism in Ubud. This study uses qualitative research methods, starting with literature studies related research about wellness tourism and in-depth interviews with wellness service providers in Ubud. In this study, the authors reviewed the literatures and analyzed the information collected from eight wellness service providers. The eight informants are determined by considering the type of wellness service scale such as spa resorts, health resorts, retreat centers, and wellness centers, located in Ubud. The results showed that wellness tourism in Ubud had fulfilled aspects and dimensions of wellness. This is reflected from the identification which was resulted where the highest-demanded wellness products in Ubud, namely yoga retreats, meditation retreats, spiritual retreats, detoxes and spa resorts. While wellness activities in Ubud are considered more relevant to Balinese-Hinduism lifestyles such as customs, cultural-religion activities and valuable-local knowledge of Balinese herbs in which are part of the wellness experience offered in Ubud. While in the terms of phase of development, the current situation of wellness tourism stays in development phase.