bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroendocrine and Behavioral Consequences of Hyperglycemia in Cancer
Authors: Vasquez Juan H , Borniger Jeremy C 
Published: March 2020

Abstract
A hallmark of cancer is the disruption of cellular metabolism during the course of malignant growth. Major focus is now on how these cell-autonomous processes propagate to the tumor microenvironment and, more generally, to the entire host system. This chain of events can have major consequences for a patient’s health and wellbeing. For example, metabolic “waste” produced by cancer cells activates systemic inflammatory responses, which can interfere with hepatic insulin receptor signaling and glucose homeostasis. Research is just now beginning to understand how these processes occur, and how they contribute to systemic symptoms prevalent across cancers, including hyperglycemia, fatigue, pain, and sleep disruption. Indeed, it is only recently that we have begun to appreciate that the brain does not play a passive role in responding to cancer-induced changes in physiology. In this review, we provide a brief discussion of how oncogene-directed metabolic reprogramming disrupts host metabolism, with a specific emphasis on cancer-induced hyperglycemia. We further discuss how the brain senses circulating glucose concentrations and how this process goes awry as a response to distant neoplastic growth. Finally, as glucose-sensing neurons control diverse aspects of physiology and behavior, we link cancer-induced changes in energy balance to neuroendocrine and behavioral consequences for the host organism.
Glucagon-like Peptide-1 Receptor Agonists versus Sodium-Glucose Cotransporter Inhibitors for Treatment of T2DM
Authors: McKee Alexis , Al-Khazaali Ali , Albert Stewart G 
Published: March 2020

Abstract

Context
Cardiovascular outcome trials (CVOT) of glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) demonstrated reduction of major adverse cardiovascular events (MACE), cardiovascular deaths (CVD), and renal outcomes.

Objective
Assist in the prescribing decision regarding severity of illness and risk for adverse events.

Design
Meta-analysis of the major CVOT and previous meta-analyses.

Main Outcome Measures
Six trials of GLP-1 RA (51 762 subjects) and 4 trials of SGLT2i (33 457 subjects) showed both drug classes reduced MACE and CVD versus controls, with neither class preferred (comparison GLP1-RA vs SGLT2i: relative rate [rr] MACE 1.04, 95% confidence interval [CI] 0.94, 1.16, P = ns; rr CVD 1.04, 95% CI 0.87, 1.24, P = ns). Hospitalization for heart failure (HHF) improved with SGLT2i (rr 0.68, CI 0.61, 0.76, P &lt; 0.001) but not with GLP-1 RA, (rr 0.93, CI 0.86,1.03, P = ns). Meta-regression suggested benefits of the SGLT2i on CVD and HHF were accentuated with the underlying rate of MACE in the cohort (i.e., &gt;10 events/1000pt*year). GLP-1 RA and SGLT2i showed reduction in renal outcomes (GLP-1 RA rr 0.83, CI 0.75, 0.91, p ≤ 0.001, SGLT2i rr 0.67, CI 0.57, 0.79, P &lt; 0.001) without a preferential difference (GLP-1 RA vs SGLT2i, rr 1.24, CI 0.95, 1.61, P = ns; relative difference (rd) 0.005, CI -0.011, 0.021, P = ns). Serious adverse events for SGLT2i were mycotic genital infections in women (number needed to harm [NNH] = 13 and diabetic ketoacidosis NNH = 595. Gastrointestinal intolerance was the serious adverse event in the GLP1-RA class (NNH = 35).

Conclusion
GLP-1 RA and SGLT2i classes showed similar reduction in MACE, CVD, and renal outcomes. SGLT2i have advantages over GLP-1 RA in reduction in HHF.
ALTERED MERISTEM PROGRAM1 regulates leaf identity independently of miR156-mediated translational repression
Authors: Fouracre Jim P. , Chen Victoria J. , Poethig R. Scott 
Published: March 2020

ABSTRACT
In Arabidopsis, loss of the carboxypeptidase ALTERED MERISTEM PROGRAM1 (AMP1) produces an increase in the rate of leaf initiation, an enlarged shoot apical meristem and an increase in the number of juvenile leaves. This phenotype is also observed in plants with reduced levels of miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, suggesting that AMP1 might promote SPL activity. However, we found that the amp1 mutant phenotype is only partially corrected by elevated SPL gene expression, and that amp1 has no significant effect on SPL transcript levels, or on the level or the activity of miR156. Although AMP1 has been reported to promote miRNA-mediated translational repression, amp1 did not prevent the translational repression of the miR156 target SPL9 or the miR159 target MYB33. These results suggest that AMP1 regulates vegetative phase change downstream of, or in parallel to, the miR156/SPL pathway, and that it is not universally required for miRNA-mediated translational repression.
Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial
Authors: Marcovecchio M. Loredana , Wicker Linda S. , Dunger David B. , Dutton Susan J. , Kopijasz Sylwia , Scudder Claire , Todd John A. , Johnson Paul R. V. 
Published: March 2020

Type 1 diabetes is a common autoimmune disease due to destruction of pancreatic β cells, resulting in lifelong need for insulin. Evidence suggest that maintaining residual β-cell function can improve glucose control and reduce risk of hypoglycaemia and vascular complications. Non-clinical, preclinical and some preliminary clinical data suggest that low-dose interleukin-2 (IL-2) therapy could block pancreatic β cells destruction by increasing the number of functional regulatory T cells (Tregs) that inhibit islet-specific autoreactive effector T cells (Teffs). However, there is lack of data on the effect of low-dose IL-2 in newly diagnosed children and adolescents with T1D as well as lack of specific data on its potential effect on β-cell function. The ‘Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD)’ is a phase 2, multicentre, double-blind, randomised, placebo-controlled trial in children and adolescents (6-18 years; having detectable C-peptide) initiated within 6 weeks of T1D diagnosis. A total of 45 participants will be randomised in a 2:1 ratio to receive either ultra-low dose IL-2 (aldesleukin), at a dose of 0.2 x 106 IU/m2 twice-weekly, given subcutaneously, or placebo, for 6 months. The primary objective is to assess the effects of ultra-low dose aldesleukin administration on endogenous β-cell function as measured by frequent home dried blood spot (DBS) fasting and post-prandial C-peptide in children and adolescents with newly diagnosed T1D. The secondary objectives are: 1) to assess the efficacy of regular dosing of aldesleukin in increasing Treg levels; 2) to confirm the clinical safety and tolerability of ultra-low dose aldesleukin; 3) to assess changes in the immune system indicating benefit or potential risk for future gains/loss in β-cell function and immune function; 4) to assess treatment effect on glycaemic control. Trial registration: EudraCT 2017-002126-20 (06/02/2019)
Validation of the Indonesian version of the graded chronic pain scale 2.0 in pain-related temporomandibular disorders
Authors: Tanti Ira , Wira Vivi Vidya Waty , Pragustine Yenni , Himawan Laura Susanti , Ariani Nina 
Published: March 2020

BACKGROUND Pain associated with oral problems is one of the most frequent chronic pain of temporomandibular disorders (TMDs). This study was conducted to analyze the psychometric properties of the Indonesian version of the graded chronic pain scale 2.0 (GCPS-ID) in Indonesian patients with TMDs.
METHODS The English version of the GCPS version 2.0 was translated and back-translated according to international guidelines. This study conducted from June to December 2016 at the Dental Hospital, Faculty of Dentistry, Universitas Indonesia, and the participants were 202 TMDs patients who had never undergone temporomandibular joint surgery or suffered facial pain for more than 6 months. The evaluation of the GCPS-ID included the internal consistency test, test-retest reliability, and construct validity tests.
RESULTS The GCPS-ID had a high internal consistency (Cronbach’s alpha = 0.896). The intraclass correlation coefficient of the pain intensity and the disability score were 0.789 and 0.706, respectively. The convergent validity demonstrated a moderately positive correlation between the GCPS-ID and the Indonesian version of oral health impact profile for TMD for pain (r = 0.595; p<0.001) and disability (r = 0.488; p<0.001). The discriminant validity between GCPS-ID and the subjective patient’s quality of life revealed a weak positive correlation (r = 0.195; p = 0.191).
CONCLUSIONS GCPS-ID is a reliable and valid assessment tool for evaluating TMD pain in Indonesia.
55  W  kilohertz-linewidth core- and in-band-pumped linearly polarized single-frequency fiber laser at 1950  nm
Authors: Guan Xianchao , Yang Changsheng , Gu Quan , Wang Weiwei , Tan Tianyi , Zhao Qilai , Lin Wei , Wei Xiaoming , Yang Zhongmin , Xu Shanhui 
Published: March 2020

Based on core- and in-band-pumped polarization-maintaining

T
m

3
+

-doped single-cladding fiber (PM-TSF, the core diameter is 9 µm) by a 1610 nm fiber laser and a distributed Bragg reflector seed laser, a linearly polarized single-frequency fiber laser (LP-SFFL) at 1950 nm with an output power of 55.3 W and a laser linewidth of 6.95 kHz is demonstrated. The output beam qualities of

M

x
2

and

M

y
2

are measured to be 1.01 and 1.03, respectively. The slope efficiency with respect to the launched pump power is 71.0%, in comparison with a theoretical quantum efficiency of 82.6%. A polarization-extinction ratio of 19 dB and an optical signal-to-noise ratio of 58 dB are obtained from the 1950 nm LP-SFFL. To the best of our knowledge, to date, this is the highest power of 2.0 µm SFFL output directly from a strict single-mode active fiber. Our experiment offers a promising solution to the current limitations of the high-performance fiber lasers at 2.0 µm, which is particularly essential for coherent detection.
Hidden linear optical response reveals crystalline symmetry
Authors: Zhu X. D. , Zhang Hang 
Published: March 2020

We show that a linear quadrupole response from a crystalline material to externally applied optical fields exists and has gone unnoticed, even though its nonlinear optical cousin has been studied and explored extensively for decades. Such a linear quadrupole response reveals the symmetry of the crystal, just as its nonlinear optical counterpart has done, and can be used to investigate phase transitions non-intrusively with high spatial and temporal resolution.
Empreendedorismo Cultural e Economia Criativa: A Companhia de Teatro “Grupo Galpão”
Authors: Reis Janaína Martins dos , Zille Luciano Pereira 
Published: March 2020

Objetivo: Analisar e descrever o empreendedorismo cultural no contexto da economia criativa, na percepção do Grupo Galpão, sediado na cidade de Belo Horizonte-MG.Metodologia: Pesquisa descritiva, de abordagem qualitativa por meio de estudo de caso. A unidade de análise foi o empreendedorismo cultural e a unidade de observação o Grupo de Teatro Galpão. A coleta dos dados foi por meio de entrevista semiestruturada e a análise pela técnica de análise de conteúdo categorial.Resultados: O grupo revelou amplo conhecimento sobre o tema, cujos principais desafios são a dificuldade de planejamento dos eventos em médio e longo prazos e a dificuldade de gerar receita exclusivamente pelo público participante. Identificou-se que a criação e manutenção do Centro Cultural tem contribuído com vários projetos de acesso à cultura de interesse da sociedade, nos quais a Lei Rouanet vem tendo papel relevante.Contribuições teóricas: Ampliação do conhecimento dos estudos relacionados ao empreendedorismo cultural, enfatizando a economia criativa, cujas pesquisas estão caminhando no sentido de alcançarem solidez do ponto de vista científico.Relevância/originalidade: Contempla principalmente os contextos acadêmico e social, no sentido de ampliar os estudos direcionados ao empreendedorismo cultural. A sua originalidade está centrada na pesquisa de uma companhia de teatro de destaque no Brasil, focando o empreendedorismo cultural na dimensão da economia criativa. Contribuições sociais/gestão: Fomenta o desenvolvimento de uma sociedade mais igualitária em relação ao espírito empreendedor, por meio da disseminação cultural, com foco nos princípios da economia criativa e da gestão empreendedora.
Psychiatric Comorbidities and Psychiatric Medication Use Are Highly Prevalent in Patients With Eosinophilic Esophagitis and Associate With Clinical Presentation
Authors: Reed Craig C. , Corder S. Ryanne , Kim Erin , Sanders Emily , Tappata Manaswita , Eluri Swathi , Dellon Evan S. 
Published: March 2020

OBJECTIVES:
The prevalence of psychiatric disease in patients with eosinophilic esophagitis (EoE) is not fully characterized. We aimed to determine the prevalence of psychiatric disease and centrally acting medication use in a cohort of children and adults with EoE and evaluated whether psychiatric disease affects the EoE clinical presentation.

METHODS:
We conducted a retrospective study of newly diagnosed cases with EoE at the University of North Carolina from 2002 to 2018. Psychiatric comorbidities and relevant treatments were extracted from the medical records. The demographic and clinical features of patients with EoE with and without psychiatric diagnoses, and those with and without psychiatric medication use, were compared.

RESULTS:
Of 883 patients (mean age 26.6 years, 68% men, 79% white), 241 (28%) had a psychiatric comorbidity. The most common diagnosis was anxiety (23%) followed by depression (17%); 28% of patients were treated pharmacologically. There were 45 patients (5%) treated pharmacologically without a psychiatric diagnosis for chronic pain syndromes, insomnia, and/or epilepsy. Cases with EoE with a psychiatric diagnosis were more likely to be women, white, and 18 years or older and to have a longer symptom duration before diagnosis.

DICUSSION:
Psychiatric comorbidities were common in EoE, seen in a third of adults and more than 1 in 7 children, and with similar proportions receiving a prescription medication. These illnesses affected the EoE presentation because psychiatric comorbidities were more likely in older, female, and white patients with a longer duration of symptoms preceding diagnosis.
What is Effective Research Communication? Towards Cooperative Inquiry with Nunavut Communities
Authors: Henri Dominique A. , Brunet Nicolas D. , Dort Hillary E. , Hambly Odame Helen , Shirley Jamal , Gilchrist H. Grant 
Published: March 2020

Communication is recognized as the foundation of developing partnerships in science. In this study, we assess the effectiveness of several communication processes, practices, and tools used by wildlife researchers in northern communities in Arctic Canada. A case study was conducted in the communities of Cape Dorset and Coral Harbour (Salliq), Nunavut, Canada, to assess the effectiveness of research communication approaches carried out by the northern marine bird research group of Environment and Climate Change Canada, which has a long-standing research relationship with these two communities. Our objectives were to 1) explore local experiences with research—marine bird research in particular, 2) examine what communication approaches and tools Nunavummiut viewed as most effective for learning about research activities and feeling engaged in the process, and 3) identify new and emerging communication needs in Nunavut communities to support more effective research partnerships. Our findings indicate that several communication methods used by wildlife researchers, such as community meetings, have become less effective because of changing information-sharing practices at the community level. Other communication practices, such as using social media, hold much promise, but as of yet are underutilized by researchers, though of interest to northern communities. Acknowledging that every northern community is unique, with context-specific priorities, capacities, and needs, effective research partnerships should be built upon communication approaches that foster cooperative inquiry and learning. In progress towards this goal, we explore two emerging and related themes: first, access to information and communication technologies in the two communities, and second, the engagement of youth in Arctic research communication and delivery.
The group of self-homotopy equivalences ofAn2-polyhedra
Authors: Costoya Cristina , Méndez David , Viruel Antonio 
Published: March 2020

AbstractLetXbe a finite typeAn2{A_{n}^{2}}-polyhedron,n≥2{n\geq 2}. In this paper, we study the quotient groupℰ⁢(X)/ℰ*⁢(X){\mathcal{E}(X)/\mathcal{E}_{*}(X)}, whereℰ⁢(X){\mathcal{E}(X)}is the group of self-homotopy equivalences ofXandℰ*⁢(X){\mathcal{E}_{*}(X)}the subgroup of self-homotopy equivalences inducing the identity on the homology groups ofX. We show that not every group can be realised asℰ⁢(X){\mathcal{E}(X)}orℰ⁢(X)/ℰ*⁢(X){\mathcal{E}(X)/\mathcal{E}_{*}(X)}forXanAn2{A_{n}^{2}}-polyhedron,n≥3{n\geq 3}, and specific results are obtained forn=2{n=2}.
Effect of ionic liquid on the extraction of uranium with pillar[5]arene-based phosphine oxide from nitric acid solutions
Authors: Gan Quan , Cai Yimin , Fu Kuirong , Yuan Lihua , Feng Wen 
Published: March 2020

Abstract
The extraction of U(VI) from aqueous nitric acid solutions with pillar[5]arene-based phosphine oxide (L) and [C8mim][NTf2] ionic liquid dissolved in 1,2-dichloroethane was explored. A great positive impact in this system was observed. The effect of IL concentration in the organic phase and HNO3 concentration in the aqueous phase is considered. The distribution ratios of U(VI) were significantly enhanced upon adding a small amount of ionic liquid as compared with organic diluent. The extraction system was also examined for its ability towards extraction of lanthanides and Th4+. The results revealed higher separation factors towards UO2
2+ over Th4+ in the presence of ionic liquid compared with organic diluent. Other factors such as C8mim+ and NTf2
− have also been considered. This extraction system has shorter equilibrium time as compared with in IL diluent. Stripping experiments showed almost quantitative back extraction of UO2
2+ within two stages. With high selectivity towards UO2
2+ and efficient back extraction, this new POP5A-ionic liquid-organic diluent system shows promise for future application of uranium recovery.
La nature du sens : Neuroception, perception ou sémioception ?
Authors: Beividas Waldir 
Published: March 2020

Résumé
La théorie sémiotique s’est développée comme une théorie de la production du sens et de sa manifestation dans les diverses pratiques humaines. Dernièrement, elle est demandée à rendre compte de l’émergence du sens, de sa nature. Pour la philosophie merleaupontienne ce point d’origine est donné dans la perception, comme le premier sol où le sens se fait. La perception détient la primauté de la construction du monde signifiant pour l’homme. Dans les sciences naturelles, les neurosciences pointent vers le cerveau, en particulier l’équipement neuronal que nous avons en tant qu’hommes, comme le siège de la construction du sens. Notre connaissance du monde vient d’une « neuroception », un néologisme inévitable pour lui donner un air de famille avec celui de la « per-ception ». Devant ces deux positions théoriques, nous pouvons en sémiologie et linguistique offrir et défendre l’hypothèse que notre connaissance du monde est péremptoirement générée dans les mailles des langages. Une opération de sémioception, basée sur l’acte sémiologique arbitraire des langages, commande la perception humaine elle-même, avec antécédence. Ce n’est pas le cerveau qui « fait de l’esprit », c’est plutôt le langage qui « fait le cerveau » humain.
Le rôle complexe de la figurativité dans la sémiotique greimassienne
Authors: Harkot-de-La-Taille Elizabeth 
Published: March 2020

Résumé La figure, dans la sémiotique greimassienne, héritant d’une élaboration polysémique chez Hjelmslev, appartient tant au plan de l’expression qu’au plan du contenu. Sur le plan du contenu, elle s’introduit au niveau discursif et renvoie à un thème, qu’elleconcrétise. Par ailleurs, dans Sémantique Structurale, les traces d’information que nos cinq sens nous apportent sont aussi appelées figures, et c’est par leur intermédiaire que le monde naturel joue un rôle dans la naissance du sens. Ces figures engendrées par la perception sont des figures d’expression et appartiennent de ce fait au plan de l’expression. L’unification des deux types de figures en une figurativité générique, située au niveau discursif et subdivisée en figurativitéstricto sensu, dite de surface, et figurativitélato sensu, dite profonde (Landowski. 2017.Com Greimas : interações semióticas. São Paulo : Editora CPS e Estação das Letras e Cores) est discutée avec l’apport d’auteurs de la sémiotique française et la structure quadratique du signe due au Groupe µ (2015.Principia semiotica : aux sources du sens. Bruxelles : Les Impressions Nouvelles : 283–292). Cette discussion nous suggère la figurativité comme transversale au parcours génératif du sens et contribuant à l’opération de conversion, dans la mesure où des traces du monde naturel refont surface sous la forme de figures du monde, sur le plan du contenu discursif.
Bidirectional Gated Recurrent Deep Learning Neural Networks for Smart Acoustic Emission Sensing of Natural Fiber–Reinforced Polymer Composite Machining Process
Authors: Wang Zimo , Dixit Pawan , Chegdani Faissal , Takabi Behrouz , Tai Bruce L. , El Mansori Mohamed , Bukkapatnam Satish 
Published: March 2020

Abstract
Natural fiber–reinforced polymer (NFRP) composites are increasingly considered in the industry for creating environmentally benign product alternatives. The complex structure of the fibers and their random distribution within the matrix basis impede the machinability of NFRP composites as well as the resulting product quality. This article investigates a smart process monitoring approach that employs acoustic emission (AE)—elastic waves sourced from various plastic deformation and fracture mechanisms—to characterize the variations in the NFRP machining process. The state-of-the-art analytic tools are incapable of handling the transient dynamic patterns with long-term correlations and bursts in AE and how process conditions and the underlying material removal mechanisms affect these patterns. To address this gap, we investigated two types of the bidirectional gated recurrent deep learning neural network (BD-GRNN) models, viz., bidirectional long short-term memory and bidirectional gated recurrent unit to predict the process conditions based on dynamic AE patterns. The models are tested on the AE signals gathered from orthogonal cutting experiments on NFRP samples performed at six different cutting speeds and three fiber orientations. The results from the experimental study suggest that BD-GRNNs can correctly predict (around 87 % accuracy) the cutting conditions based on the extracted temporal-spectral features of AE signals.