bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-FDG PET/CT in asymptomatic patients with COVID-19: The submerged iceberg surfaces
Authors: Colandrea Marzia , Gilardi Laura , Travaini Laura Lavinia , Fracassi Silvia L. V. , Funicelli Luigi 
Published: April 2020

Abstract
Purpose: the aim of this case series is to describe our experience in diagnosis and management of oncological asymptomatic patients with COVID-19 submitted to 18F-FDG PET/CT.Methods: from March 9 to March 31, 2020, we identified 5 patients who had PET/CT findings suspicious for COVID-19, but no symptom of infection.Results: the first three patients performed SARS-CoV-2 test in a COVID-dedicated centre, while the fourth and fifth in our Institution, in agreement with a new internal procedure. The SARS-CoV-2 test yielded positive results in all five patients.Conclusions: in this COVID-19 emergency, our task as nuclear medicine physicians is to be able to identify imaging findings suggestive of the disease and to manage patients without overload the hospital system.
El impacto del Tratado de Libre Comercio entre México, Estados Unidos y Canadá en el sector agropecuario de Coahuila
Authors: Vidaurrázaga Obezo René 
Published: April 2020

El presente trabajo analiza la importancia que tiene el sector agropecuario en la economía de Coahuila; el impacto del Tratado de Libre Comercio en este sector, y las perspectivas con la operación de dicho tratado. El sector agropecuario de Coahuila se encuentra rezagado en comparación con el resto de los sectores económícos de la entidad, así como de las actividades agrícolas de otras regionesdel país tal como el noroeste y aún más con los Estados Unidos de América y Canadá. En estas condiciones en que se encuentra el sector agropecuario de Coahuila y si continúan las mismas políticas para el campo, el proceso de competencia con la operación del TLC no se presentará en toda su expansión una vez vencidos los plazosacordados para abrir totalmente las fronteras. Del conjunto de ramas que componen el sector agropecuario de Coahuila, son contadas las que tienen posibilidades de competir en el mercado internacional.
Rational Design and Intramolecular Cyclization of Hotspot Peptide Segments at YAP–TEAD4 Complex Interface
Authors: Zhang Dingwa , He Deyong , Pan Xiaoliang , Liu Lijun 
Published: April 2020

Background:The Yes-Associated Protein (YAP) is a central regulator of Hippo pathway involved in carcinogenesis, which functions through interaction with TEA Domain (TEAD) transcription factors. Pharmacological disruption of YAP–TEAD4 complexes has been recognized as a potential therapeutic strategy against diverse cancers by suppressing the oncogenic activity of YAP.Objective:Two peptides, termed PS-1 and PS-2 are split from the interfacial context of YAP protein. Dynamics simulations, energetics analyses and fluorescence polarizations are employed to characterize the intrinsic disorder as well as binding energy/affinity of the two YAP peptides to TEAD4 protein.Methods:Two peptides, termed PS-1 and PS-2 are split from the interfacial context of YAP protein. Dynamics simulations, energetics analyses and fluorescence polarizations are employed to characterize the intrinsic disorder as well as binding energy/affinity of the two YAP peptides to TEAD4 protein.Result:The native conformation of PS-2 peptide is a cyclic loop, which is supposed to be constrained by adding a disulfide bond across the spatially vicinal residue pair Arg87-Phe96 or Met86- Phe95 at the peptide’s two ends, consequently resulting in two intramolecular cyclized counterparts of linear PS-2 peptide, namely PS-2(cyc87,96) and PS-2(cyc86,95). The linear PS-2 peptide is determined as a weak binder of TEAD4 (Kd= 190 μM), while the two cyclic PS-2(cyc87,96) and PS-2(cyc86,95) peptides are measured to have moderate or high affinity towards TEAD4 (Kd= 21 and 45 μM, respectively).Conclusion:PS-1 and PS-2 peptides are highly flexible and cannot maintain in native active conformation when splitting from the interfacial context, and thus would incur a considerable entropy penalty upon rebinding to the interface. Cyclization does not influence the direct interaction between PS-2 peptide and TEAD4 protein, but can largely reduce the intrinsic disorder of PS-2 peptide in free state and considerably minimize indirect entropy effect upon the peptide binding.
Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review
Authors: Kalam Muhammad Nasir , Rasool Muhammad Fawad , Rehman Asim Ur , Ahmed Naveed 
Published: April 2020

Background:Nobel laureate Sir James Black’s molecule, propranolol, still has broad potential in cardiovascular diseases, infantile haemangiomas and anxiety. A comprehensive and systematic review of the literature for the summarization of pharmacokinetic parameters would be effective to explore the new safe uses of propranolol in different scenarios, without exposing humans and using virtual-human modeling approaches.Objective:This review encompasses physicochemical properties, pharmacokinetics and drug-drug interaction data of propranolol collected from various studies.Methods:Clinical pharmacokinetic studies on propranolol were screened using Medline and Google Scholar databases. Eighty-three clinical trials, in which pharmacokinetic profiles and plasma time concentration were available after oral or IV administration, were included in the review.Results:The study depicts that propranolol is well absorbed after oral administration. It has dose-dependent bioavailability, and a 2-fold increase in dose results in a 2.5-fold increase in the area under the curve, a 1.3-fold increase in the time to reach maximum plasma concentration and finally, 2.2 and 1.8-fold increase in maximum plasma concentration in both immediate and long-acting formulations, respectively. Propranolol is a substrate of CYP2D6, CYP1A2 and CYP2C19, retaining potential pharmacokinetic interactions with co-administered drugs. Age, gender, race and ethnicity do not alter its pharmacokinetics. However, in renal and hepatic impairment, it needs a dose adjustment.Conclusion:Physiochemical and pooled pharmacokinetic parameters of propranolol are beneficial to establish physiologically based pharmacokinetic modeling among the diseased population.
Immunogenicity and Biodistribution of Anthrax DNA Vaccine Delivered by Intradermal Electroporation
Authors: Kim Na Young , Son Won Rak , Choi Jun Young , Yu Chi Ho , Hur Gyeung Haeng , Jeong Seong Tae , Shin Young Kee , Hong Sung Youl , Shin Sungho 
Published: April 2020

Purpose:
Anthrax is a lethal bacterial disease caused by gram-positive bacterium Bacillus
anthracis and vaccination is a desirable method to prevent anthrax infections. In the present study, DNA
vaccine encoding a protective antigen of Bacillus anthracis was prepared and we investigated the influence
of DNA electrotransfer in the skin on the induced immune response and biodistribution.

Methods and Results:
The tdTomato reporter gene for the whole animal in vivo imaging was used to
assess gene transfer efficiency into the skin as a function of electrical parameters. Compared to that with
25 V, the transgene expression of red fluorescent protein increased significantly when a voltage of 90 V
was used. Delivery of DNA vaccines expressing Bacillus anthracis protective antigen domain 4 (PAD4)
with an applied voltage of 90 V induced robust PA-D4-specific antibody responses. In addition, the
in vivo fate of anthrax DNA vaccine was studied after intradermal administration into the mouse. DNA
plasmids remained at the skin injection site for an appropriate period of time after immunization. Intradermal
administration of DNA vaccine resulted in detection in various organs (viz., lung, heart, kidney,
spleen, brain, and liver), although the levels were significantly reduced.

Conclusion:
Our results offer important insights into how anthrax DNA vaccine delivery by intradermal
electroporation affects the immune response and biodistribution of DNA vaccine. Therefore, it may
provide valuable information for the development of effective DNA vaccines against anthrax infection.
High-Sensitivity C-Reactive Protein and Lipoprotein-Associated Phospholipase A2 in Predicting Recurrence and Severity of Stenosis in Symptomatic Intracranial Atherosclerotic Disease
Authors: Krishnamoorthy Soumya , Damayanthi Deepa , Gopala Srinivas , Paul Rejith , Sylaja P.N. 
Published: April 2020

Background:
Symptomatic intracranial atherosclerotic disease (sICAD) is associated with risk of recurrence of cerebral ischemic events in 4-19% of stroke patients annually. Previous studies indicate elevated high-sensitivity C-Reactive Protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) to be associated with risk of recurrence.

Objective:
This prospective, observational study investigated serum levels of hs-CRP and the activity of Lp-PLA2 in patients with sICAD in predicting the risk of long-term stroke recurrence.

Methods:
We enrolled 48 patients with sICAD at 3 months from onset. The demographics, clinical,
and imaging characteristics were recorded. Serum hs-CRP and Lp-PLA2 activity were assessed
using automated high-sensitivity C-reactive protein assay and photometric technique, respectively.
Patients were followed up at 6 months and 1 year and the presence of new vascular events
was recorded.

Results:
The mean age of our study population was 59.5 ± 10.3 years and 91.7% were men. Four
patients developed recurrent strokes during follow-up. The mean Hs-CRP was elevated in patients
with events than in patients without events (5.9 ± 10.4 mg/L vs. 1.7 ± 2.4 mg/L, P=0.03). However,
there was no significant association of mean Lp-PLA2 activity (118.3±42.9 nmol/min/ml vs. 111.9
± 34.2 nmol/min/ml, P=0.73) with recurrence. Elevation of hs-CRP (3.02 ± 4.8 mg/L vs. 0.95 ±
0.57mg/L, P=0.02) and Lp-PLA2 activity (120.1±40.3 nmol/min/ml vs. 103.3 ± 23.9 nmol/min/ml,
P=0.04) was correlated with high-grade stenosis in these patients.

Conclusion:
Our study suggests serum levels of hs-CRP may serve as a predictor of long-term
stroke recurrence risk in sICAD and elevation of hs-CRP and Lp-PLA2 correlated with the severity
of stenosis in symptomatic intracranial atherosclerotic disease.
A Novel Electrochemical Sensor Based on Au-rGO Nanocomposite Decorated with Poly(L-cysteine) for Determination of Paracetamol
Authors: Zhang Lin , Si Xiaojing , Yan Xiaoxia , He Haibo , Deng Dongmei , Luo Liqiang 
Published: April 2020

Background:
Paracetamol is a common antipyretic and analgesic drug, but its excessive
intake can accumulate toxic metabolites and cause kidney and liver damage, so it is critical to determine
the content of paracetamol for clinical diagnosis and dose use.

Methods:
Au-reduced graphene oxide (Au-rGO) nanocomposite decorated with poly(L-cysteine) on
carbon paste electrode was fabricated for the determination of paracetamol. Au-rGO was first coelectrodeposited
on the carbon paste electrode surface. Afterwards, L-cysteine was electropolymerized
to fabricate the Au-rGO/poly(L-cysteine) modified carbon paste electrode. Scanning electron
microscope was used to characterize the morphology of Au-rGO and poly(L-cysteine)/Au-rGO. The
electrochemical properties of the sensor were studied by cyclic voltammetry and differential pulse
voltammetry.

Results:
After exploring the optimal conditions, the sensor showed a wide linear response for paracetamol
detection in the range of 1-200 μM with a detection limit of 0.5 μM (S/N = 3).

Conclusion:
The fabricated sensor demonstrated good sensitivity with rapid detection capacity in real
samples.
Risk Management Process Into Project Lifecycle: A case of Malaysian landscape architecture projects
Authors: S.Muthueeran Adam Aruldewan , Mohd Tahir Osman , Ibrahim Roziya , Abd-Karim Saipol Bari 
Published: April 2020

The risk management process is an integral part of all project activities and proportionally customized as one process. This paper prepared to review risk management process integration into the landscape architecture project lifecycle in Malaysia. Data collected from three completed landscape architecture projects studied through structured interviews and project document reviews. The data analyzed using content and thematic analysis. The study found the ineffective risk management process integration into the project lifecycle with the result of the incomplete, unplanned and intended process, and redundant activity ow. Specific integration strategies recommended accommodating landscape architecture project context for practical risk management applications.Keywords: risk management process; project lifecycle; landscape architecture projecteISSN 2398-4295 ©2020 The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: http://dx.doi.org/10.21834/ajbes.v5i18.187
Procesos urbanos. presentación número 6
Authors: Martinez-Osorio Pedro Arturo , Castellanos Tuirán Alexandra Isabel 
Published: April 2020

Con mucho gusto presentamos el número 6 de la revista científica Procesos Urbanos, adscrita a la Facultad de Ciencias Básicas, Ingeniería y Arquitectura de la Corporación Universitaria del Caribe – CECAR, Colombia.
En este número hemos reunido un grupo de artículos de gran actualidad y pertinencia para el desarrollo de las disciplinas de la arquitectura, el urbanismo y el diseño. Los cuales muestran los avances de importantes investigaciones y se reflexiona con relación a aspectos clave en el debate sobre las formas de habitar en el siglo XXI.
Influencia de la implicación familiar sobre el rendimiento académico en la etapa de educación primaria
Authors: Barrientos Montiel Laura , Arranz de la Fuente María 
Published: April 2020

La investigación que se presenta tuvo como objetivo principal establecer la relación existente entre la implicación familiar y el rendimiento académico en estudiantes de primaria de la provincia de León (España). En este estudio han participado un total de 224 niños y niñas, 60 profesores, 15 padres y 45 madres, de colegios públicos, concertados y privados de la etapa de Educación Primaria, a quienes se les aplicaron diversos cuestionarios ad-hoc. Los resultados de la investigación fueron variados, entre ellos, a mayor implicación de los padres, mayores resultados académicos de sus hijos. Además, los padres se implican más cuanto más pequeños son. Se demuestra, por tanto, que un posible factor del rendimiento académico puede ser la implicación parental.
The Value of Implicit Political Connections
Authors: Broadstock David , Chen Xiaoqi , Cheng C. S. Agnes , Huang Wenli 
Published: April 2020

ABSTRACT
We investigate whether the aggregated political relations of a firm's top management team (TMT) add value to the firm's performance. We distinguish between the political relations that arise from TMT's own work experience, which are termed direct political connections (DPC), and the relations that TMT develops from working for the same institution with the government officials, which are termed implicit political connections (IPC). We find that IPC are positively associated with firm performance and that they often have a stronger effect than DPC do. We also find that the effect of IPC on firm value is stronger in SOEs and in firms located in under-developed provinces. Moreover, we find that after the anti-corruption campaign, the effect of DPC decreases but the effect of IPC does not significantly change. Overall, our results suggest the importance of investigating a firm's aggregated political connections, especially its IPC.
JEL Classifications: G32; D72; J33; L33.
Data Availability: Data are available from the public sources cited in the text.
KLASIFIKASI KUALITAS PERMUKIMAN MENGGUNAKAN CITRA QUICKBIRD DI KECAMATAN MANDIANGIN KOTO SELAYAN KOTA BUKITTINGGI
Authors: Pratiwi Sri Bening , Triyatno Triyatno , Syahar Fitriana 
Published: April 2020

ABSTRACT
The purpose of this research are (1) describe the quality parameters of settlement, (2) analyze the distribution of quality of settlements, (3) test the accuracy of interpretation Quickbird. Methods used for the quality of settlements is scoring and overlay. Accuracy of interpretation used confusion matrix method. Based on research result show that (1) the quality parameter of the settlements is the density of the settlements has a medium quality of 120 Ha, the pattern of the building layout has a bad quality of 182 Ha, tree protective settlement has a bad quality of 233 Ha, the road width has bad quality the extent of 207 Ha, the condition of residential road has good quality which is 204 Ha, and the residential location variable has medium quality which is 91 Ha. (2) the distribution of settlement quality in the subdistric Mandiangin Koto Selayan for the medium quality of settlements are having an area of 125 Ha, the quality of bad settlements has an area of 118 Ha. The medium quality of the settlements is the most in the village Kubu Gulai Bancah while the bad quality is the most in the village Campago Guguak Bulek. (3) test image accuracy using confution matrix produce accuracy of image that is 94,73%.
KECUKUPAN BUKU TEKS “WHEN ENGLISH RINGS A BELL” DALAM MEMENUHI KOMPETENSI DASAR BAHASA INGGRIS DI SMPN1 PONOROGO
Authors: Indriastuti Niken Reti 
Published: April 2020

Artikel ini bertujuan untuk memberi gambaran tentang persepsi guru bahasa Inggris di SMPN 1 Ponorogo terhadap penggunaan buku ajar “When English Rings A Bell” dalam memenuhi kompetensi dasar mata pelajaran bahasa Inggris. Penelitian ini dilaksanakan di SMPN 1 Ponorogo dengan sumber data utama guru bahasa Inggris dan siswa kelas 8 dan 9 sebagai sumber data kedua. Pengambilan data dilaksanakan pada bulan September dengan teknik wawancara dan angket. Hasil pengolahan data menunjukkan bahwa menurut guru mereka mengalami kesulitan dalam menerapkan langkah-langkah pembelajaran dalam proses pembelajaran di kelas, hal ini didukung oleh anggapan siswa yang juga kesulitan mempelajari buku teks tanpa bimbingan dari guru. Walaupun secara isi materi sudah sesuai dengan kompetensi dasar yang telah dicantumkan dalam kurikulum 2013 , namun untuk pencapaian KD buku ini kurang efektif.
SCAFFOLDING MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS DALAM PEMBELAJARAN MATEMATIKA
Authors: Nugroho Purna Bayu 
Published: April 2020

Berpikir kritis merupakan merupakan kemampuan yang harus dimiliki oleh siswa. Namun fakta saat ini menunjukkan bahwa ditemukannya kemampuan berpikir kritis siswa yang rendah terlihat dari kualitas pertanyaan dan jawaban siswa pada saat proses pembelajaran berlangsung. Scaffolding merupakan salah satu pembelajaran yang dapat meningkatkan kemampuan berpikir kritis dalam pembelajaran matematika. scaffolding terdiri dari environtment provisions, explaining, reviewing dan restructuring, serta development conceptual thinking. Beberapa teknik scaffolding yang dapat digunakan adalah (1) memodelkan perilaku tertentu (modeling of desired behaviors), menyajikan penjelasan (offering explanations), mengundang partisipasi siswa (inviting student participation), verifikasi dan klarifikasi pemahaman siswa (verifying and clarifying student understandings), dan mengajak siswa memberikan petunjuk/kunci (inviting students to contribute clues); (2) scaffolding dengan menekankan pada penggunaan pertanyaan Socratik dan pertanyaan open-ended. Keyword: Berpikir Kritis, Scaffolding dan Pembelajaran Matematika.
STRES KERJA BERPENGARUH TERHADAP KINERJA PEGAWAI DENGAN MOTIVASI SEBAGAI MEDIASI DI DINAS PARIWISATA KLUNGKUNG
Authors: Mahaputra I Gede Yuma Adithya , Ardana I Komang 
Published: April 2020

Kinerja pegawai merupakan hasil kerja secara kuantitas maupun kualitas yang dicapai seorang pegawai dalam melaksanakan tugas sesuai dengan tanggung jawab yang telah diberikan. Tujuan penelitian ini adalah untuk mengetahui peran motivasi memediasi pengaruh stres kerja terhadap kinerja pegawai di Dinas Pariwisata Klungkung. Penelitian ini menggunakan sampel sebanyak 94 orang, dengan metode teknik sampling jenuh. Pengumpulan data dilakukan melalui observasi, wawancara dan kuesioner. Teknik analisis yang digunakan pada penelitian ini adalah analisis Jalur. Hasil penelitian ini menemukan bahwa stres kerja berpengaruh positif dan signifikan terhadap kinerja pegawai. Stres kerja berpengaruh positif dan signifikan terhadap motivasi. Motivasi berpengaruh positif dan signifikan terhadap kinerja pegawai. Motivasi memediasi pengaruh stres kerja terhadap kinerja pegawai. Implikasi dari hasil penelitian yaitu stres kerja dan motivasi secara nyata dapat meningkatkan kinerja pegawai, ketika stres yang dirasakan oleh pegawai dapat meningkatkan motivasi, maka motivasi yang dirasakan oleh pegawai menjadi semakin kuat sehingga berpotensi meningkatkan kinerja pegawai.
Kata kunci : kinerja karyawan, motivasi, stres kerja
PERAN KEPUASAN KONSUMEN MEMEDIASI HUBUNGAN KUALITAS PRODUK DAN PERSEPSI HARGA DENGAN KEPUTUSAN PEMBELIAN ULANG
Authors: Prayoni Ida Ayu , Respati Ni Nyoman Rsi 
Published: April 2020

This study aims to determine the effect of product quality and price perception on consumer satisfaction and repurchase decisions on consumers who buy and use Pepsodent toothpaste. This research was conducted in Denpasar City with a sample size of 105 respondents with non-probability methods in the form of purposive sampling. Data collection was carried out through questionnaires with as many as 15 indicators measured using a Likert scale. Data analysis techniques used in this study are path analysis techniques with classical assumption test and sobel test. The results of the study stated that the variables of customer satisfaction, product quality variables and price perception variables had a positive and significant effect on repurchase decisions.
Keywords: product quality, price perception, customer satisfaction, repeat purchase decisions
PENGARUH PEMBERDAYAAN PEGAWAI, DUKUNGAN ORGANISASI DAN KOMPENSASI TERHADAP KOMITMEN ORGANISASIONAL
Authors: Desniari Kadek , Dewi A.A Sagung Kartika 
Published: April 2020

The purpose of this study was to determine the effect of employee empowerment, organizational support and compensation on organizational commitment. This research was conducted at Kementerian Pekerjaan Umum dan Perumahan Rakyat Balai Wilayah Sungai Bali-Penida. The number of samples taken was 65 employees with contract / non civil servant status. The analysis technique used is multiple linear regression. Based on the results of the analysis it was found that employee empowerment, organizational support and compensation simultaneously had a positive and significant effect on organizational commitment. Partial employee empowerment has a significant effect on organizational commitment. Organizational support partially influences organizational commitment. Compensation also has a partially significant effect on organizational commitment.
Keywords: employee empowerment, organizational support, compensation, organizational commitment.