bluuebunny/crossref_metadata_2025_split huggingface dataset:
РECULIARITIES OF QUALITY OF LIFE IN BREAST CANCER PATIENTS WITH DIFFERENT DEGREES OF OBESITY DURING SURGICAL AND RADIATION TREATMENT
Authors: Prokhach N. , Sorochan P. , Gromakova I. , Shevtsov V. , Shutov S. 
Published: June 2020

Purpose. Determination of the baseline peculiarities and dynamics of the quality of life (QOL) in patients with breast cancer (BC) with obesity during surgical and radiation treatment.
Materials and methods. 45 patients with stage II–III breast cancer were examined at the stages of combined treatment. The levels of insulin, leptin, C-reactive protein, interleukin-6 (IL-6) in the blood serum and hematological parameters were determined. All patients underwent an anthropometric examination and calculated body mass index (BMI). The analysis of heart rate variability was performed using the methods of time and spectral analysis and the method of variational pulsometry. Assessment of QOL was performed using the QLQ-C30 questionnaire.
The results. All patients were divided into 4 groups based on BMI. The level of QOL and the severity of psychosomatic disorders (PD) before the start of therapy, after surgical and radiation treatment were analyzed. A low level of QOL and the highest severity of PD in patients with degree III obesity at all stages of treatment were established. The most significant predictors of the development of individual PD in patients with breast cancer have been established.
Conclusions. In patients with breast cancer who receive anticancer treatment, the level of QOL, the number and severity of PD depends on the degree of obesity. The most significant predictors of PD development are glucose, IL-6, index of centralization and BMI.
CHARACTERIZATION OF SOME BIOLOGICAL FEATURES OF CARCINOGENESIS IN THE DEVELOPING OF GASTRIC CANCER
Authors: Кrasnoselskyi N. , Movchan O. , Ponomariov I. 
Published: June 2020

Purpose of the work: the ability to increase the effectiveness of comprehensive treatment of patients with stomach cancer by individualization based on the definition of carcinogenesis indicators of the malignant process.
Materials and methods: 80 patients with stomach cancer were examined, who were identified by MSI on loci VAT 25; VAT 26, the proliferation index of Ki-67 and the p53 gene mutation. The frequency of wild and mutant variants of the p53 gene was studied according to statement of the VAT 25 ta VAT 26 genes stability. In order to assess the prolefethative potential of cells in stomach cancer, the tumor tissue studied the expression of Ki-67, depending on the presence of instability of microsatellites in the loci VAT 25 ta VAT 26. The level of proliferation activity was also assessed depending on the presence of a p53 mutation.
Results: The presence of MSI in tumor cells on the locus of VAT 25, there was in most cases a wild version of the gene p53. The absence of MSI according to these loces, the p53 mutation was observed more often. When comparing the differences between them, there were found that in the absence of MSN on VAT 26, the ratio between the absence of a p53 mutation and its presence was reliably different from the ratio of instability. That is why, this can be argued that in stomach cancer mutation of the p53 gene was observed mainly in tumors with the absence of MSN on loci VAT 25 ta 26.
Conclusions. And now has been proven, that the data suggest that there are a multifaceted genetic disorder in carcinogenesis. In tumors with preserved function of stability genes, that is why, with the possibility of restoring chromosomal breakdowns, the occurrence and proliferation of malignant cells is associated with the violation of apoptosis at critical points in the process of cell division. In this case, this realize due to the impossibility of mutant form of the p53 gene to synthesize the necessary quarter configuration of the corresponding protein with the latter’s continued inability to stop the process of DNA replication.
In this topic has been established that the mutation of the main control gene leads to loss of control over DNA and can contribute to the emergence of a malignant cell, and further loss of cell differentiation is caused by other factors. Furthermore has been revealed that the proliferative activity of swollen cells in stomach cancer has a clear association with the instability of microsatellites on both studied loca of chromosomes.
FEATURES OF INTENSIVE THERAPY OF ENTERAL INSUFFICIENCY SYNDROME IN CANCER PATIENTS AFTER MULTIORGAN OPERATIONS
Authors: Krasnoselskyi М. , Krutko Y. , Pavlyuchenko O. 
Published: June 2020

Purpose. To determine the features of intensive care of enteral insufficiency syndrome (EIS) in cancer patients after multiorgan surgery.
Materials and methods. The work is based on the analysis of data from the literature and the survey of 36 cancer patients who underwent multiorgan thoracic, abdominal, retroperitoneal operative interventions. The severity of patients’ status was assessed using SOFA scale depending on the stage of ESI. The qualitative and quantitative composition of the bacterial flora of intestinal contents was studied.
Results. The increase in number of advanced and multi-organ surgery in cancer treatment can be noted. Statistical data showed that in 2018–2019 operative interventions on the chest organs comprised 47 %, and on abdominal cavity — 51 %. Regardless of the localization of surgery on various anatomical and physiological sites, the enteral insufficiency manifests in 39 % of all surgical interventions. The mortality rate due to enteral insufficiency is about 46 %, and SPOI complications are noted in 78 % of cases. Compensated and subcompensated EI in the postoperative period occurs in 95 %. A new method of electrochemical detoxication using sodium hypochlorite was suggested for EI patients treatment in order to reduce the indices of their pathogenic gut microbocenosis.
This method allowed to decrease the yield of E. сoli by 57,5 %, Enterococcus faecalis — by 72,3 % during the first day. At the end of study the yield of Staphilococcus xylosus dropped by 84,3 %, Candida lusitaniae and Candida spp. — by 98,3 %. Enterobacter aggomerans was reduced by 50,4 %, Staphilococcus haemolyticus and St. aureus — by 56,8 %.
Conclusions. Treatment of patients with SEI allowed to decrease the rate of complications 1.4 times, the treatment time in intensive care departmet was shortened 1.7 times, treatment costs were reduced 2.4 times. Thus, it seems reasonable to pay more attention to the enteral insufficiency, particlualrly to disturbances of microbiocenosis as a marker of septic complications, in routine clinical practice.
Microphysics and dynamics of snowfall associated with a warm conveyor belt over Korea
Authors: Gehring Josué , Oertel Annika , Vignon Étienne , Jullien Nicolas , Besic Nikola , Berne Alexis 
Published: June 2020

Abstract. On 28 February 2018, 57 mm of precipitation associated with a warm conveyor belt (WCB) fell within 21 h over South Korea. To investigate how the large-scale circulation influenced the microphysics of this intense precipitation event, we used radar measurements, snowflake photographs and radiosounding data from the International Collaborative Experiments for Pyeongchang 2018 Olympic and Paralympic Winter Games (ICE-POP 2018).
The WCB was identified with trajectories computed with analysis wind fields from the Integrated Forecast System global atmospheric model. The WCB was collocated with a zone of enhanced wind speed of up to 45 m s−1 at 6500 m a.s.l., as measured by a radiosonde and a Doppler radar. Supercooled liquid water (SLW) with concentrations exceeding 0.2 g kg−1 was produced during the rapid ascent within the WCB. During the most intense precipitation period, vertical profiles of polarimetric radar variables show a peak and subsequent decrease in differential reflectivity as aggregation starts. Below the peak in differential reflectivity, the specific differential phase shift continues to increase, indicating early riming of oblate crystals and secondary ice generation. We hypothesise that the SLW produced in the WCB led to intense riming. Moreover, embedded updraughts in the WCB and turbulence at its lower boundary enhanced aggregation by increasing the probability of collisions between particles.
This suggests that both aggregation and riming occurred prominently in this WCB. This case study shows how the large-scale atmospheric flow of a WCB provides ideal conditions for rapid precipitation growth involving SLW production, riming and aggregation. Future microphysical studies should also investigate the synoptic conditions to understand how observed processes in clouds are related to large-scale circulation.
Why do models perform differently on particulate matter over East Asia? A multi-model intercomparison study for MICS-Asia III
Authors: Tan Jiani , Fu Joshua S. , Carmichael Gregory R. , Itahashi Syuichi , Tao Zhining , Huang Kan , Dong Xinyi , Yamaji Kazuyo , Nagashima Tatsuya , Wang Xuemei , Liu Yiming , Lee Hyo-Jung , Lin Chuan-Yao , Ge Baozhu , Kajino Mizuo , Zhu Jia , Zhang Meigen , Liao Hong , Wang Zifa 
Published: June 2020

Abstract. This study compares the performance of 12 regional
chemical transport models (CTMs) from the third phase of the Model
Inter-Comparison Study for Asia (MICS-Asia III) on simulating the
particulate matter (PM) over East Asia (EA) in 2010. The participating
models include the Weather Research and Forecasting model coupled with Community Multiscale Air Quality (WRF-CMAQ; v4.7.1 and v5.0.2), the Regional Atmospheric Modeling System coupled with CMAQ (RAMS-CMAQ; v4.7.1 and v5.0.2), the Weather Research and Forecasting model coupled with chemistry (WRF-Chem; v3.6.1 and v3.7.1), Goddard Earth Observing System coupled with chemistry (GEOS-Chem), a non-hydrostatic model coupled with chemistry (NHM-Chem), the Nested Air Quality Prediction Modeling System (NAQPMS) and the NASA-Unified WRF (NU-WRF). This study investigates three model processes as the possible reasons for different model performances on PM.
(1) Models perform very differently in the gas–particle conversion of
sulfur (S) and oxidized nitrogen (N). The model differences in sulfur
oxidation ratio (50 %) are of the same magnitude as that in SO42-
concentrations. The gas–particle conversion is one of the main reasons for
different model performances on fine mode PM. (2) Models without dust
emission modules can perform well on PM10 at non-dust-affected sites
but largely underestimate (up to 50 %) the PM10 concentrations at
dust sites. The implementation of dust emission modules in the models has
largely improved the model accuracies at dust sites (reduce model bias to
−20 %). However, both the magnitude and distribution of dust pollution
are not fully captured. (3) The amounts of modeled depositions vary among
models by 75 %, 39 %, 21 % and 38 % for S wet, S dry, N wet and N
dry depositions, respectively. Large inter-model differences are found in
the washout ratios of wet deposition (at most 170 % in India) and dry
deposition velocities (generally 0.3–2 cm s−1 differences over inland
regions).
The role of prior assumptions in carbon budget calculations
Authors: Sanderson Benjamin 
Published: June 2020

Abstract. Cumulative emissions budgets and net-zero emission target dates are often used to frame climate negotiations (Frame et al., 2014; Millar et al., 2016; Van Vuuren et al., 2016; Rogelj et al., 2015b; Matthews et al., 2012). However, their utility for near-term policy decisions is confounded by uncertainties in future negative emissions capacity (Fuss et al., 2014; Smith et al., 2016; Larkin et al., 2018; Anderson and Peters, 2016), in the role of non-CO2 forcers (MacDougall et al., 2015) and in the long-term Earth system response to forcing (Rugenstein et al., 2019; Knutti et al., 2017; Armour, 2017). Such uncertainties may impact the utility of an absolute carbon budget if peak temperatures occur significantly after net-zero emissions are achieved, the likelihood of which is shown here to be conditional on prior assumptions about the long-term dynamics of the Earth system. In the context of these uncertainties, we show that the necessity and scope for negative emissions deployment later in the century can be conditioned on near-term emissions, providing support for a scenario framework which focuses on emissions reductions rather than absolute budgets (Rogelj et al., 2019b).
Managing Risks and Exposures to Silica in Training and Assessment Activities in Vocational Education and Training
Authors: Skiba Richard 
Published: June 2020

A number of activities in workplaces, such as such as those including cutting, grinding, sanding, drilling, loading or demolishing products that contain silica, can produce respirable particles of crystalline silica dust that are small enough to inhale. Inhalation of crystalline silica can cause silicosis which is incurable. Work practices are critical to prevent the condition from occurring and safe work practices are as relevant to workplaces as they are to training environments. This study considers methods of risk control and training practices such that silicosis is prevented.Training requirements are profiled in a vocational education and training setting and must include: crystalline silica hazards and health risks, including silicosis; effective use controls; use and maintenance of personal protective equipment, including Respiratory Protective Equipment; safe waste disposal; and, practices for personal decontamination. The training environment must be designed in a manner to allow for engineering controls, such as on-tool water suppression or on-tool dust extraction, to be utilised.
Correlation of the Permian-Triassic Ore-Bearing Intrusions of the Norilsk Region with the Volcanic Sequence of the Siberian Traps Based on the Paleomagnetic Data
Authors: Latyshev A. V. , Rad’ko V. A. , Veselovskiy R. V. , Fetisova A. M. , Pavlov V. E. 
Published: June 2020

Abstract
We present detailed paleomagnetic data from the Permian-Triassic Cu-Ni-Pt–bearing intrusions of the Norilsk region (northwestern Siberian platform). Based on the analysis of geomagnetic secular variations recorded in the intrusions, we correlate the Norilsk ore-bearing intrusions with the Siberian Traps volcanic sequences in the region. The similarity of paleomagnetic directions of the ore-bearing intrusions to those of the Morongovsky and Mokulaevsky volcanic formations suggests that the emplacement of these lavas and intrusions occurred during the same stage of the magmatic activity. Furthermore, some weakly mineralized intrusions and barren nondifferentiated sills demonstrate paleomagnetic directions close to those of the ore-bearing intrusions. This implies that ore-bearing, weakly mineralized, and barren intrusions were emplaced during the same stage of magmatic activity. On the other hand, the paleomagnetic directions of different ore-bearing intrusions (Norilsk 1, Talnakh, and Kharaelakh), while close, are statistically different. Thus, the formation of these three intrusions and their satellites corresponds to discrete magmatic events within the same stage of magmatic activity. Based on the paleomagnetic data, the emplacement duration of individual intrusions can be estimated as &lt;10 k.y. Our correlation scheme is consistent with some genetic models for the ore-bearing intrusions. The analysis of geomagnetic secular variations can be used as an independent tool for the investigation of other Cu-Ni and platinum group element-bearing magmatic complexes.
Tussen hoop en vrees
Authors: Lawson R.A. (Rick) 
Published: June 2020

Tussen hoop en vrees
In de naoorlogse jaren werd de basis gelegd voor het huidige stelsel van Europese bescherming van mensenrechten. Deze bijdrage schetst een beeld van de omstandigheden waaronder het Europees Verdrag voor de Rechten van de Mens tot stand kwam, en de overwegingen die daarbij een rol speelden. Dat roept dan ook de vraag op in hoeverre het EVRM voldoet aan zijn oorspronkelijke doelstellingen.
Neurenberg als wegbereider voor het internationale strafrecht
Authors: van der Wilt H.G. (Harmen) 
Published: June 2020

Neurenberg als wegbereider voor het internationale strafrecht
De 75-jarige herdenking van de historische verrichtingen van het Neurenberg Tribunaal biedt een mooie gelegenheid om de balans op te maken van de staat van het internationale strafrecht. In het licht van de grillige veranderingen in de opvattingen over de normatieve en politieke levensvatbaarheid van internationaal strafrecht wordt in dit essay ingegaan op bijdrage van het Neurenberg Tribunaal aan de ontwikkeling van het internationale strafrecht.
Reflectance confocal microscopy features of facial angiofibromas
Authors: Millán-Cayetano José-Francisco , Yelamos Oriol , Rossi Anthony M , Marchetti Michael A. , Jain Manu 
Published: June 2020

Facial angiofibromas are benign tumors presenting as firm, dome-shaped flesh-colored to pink papules, typically on the nose and adjoining central face. Clinically and dermoscopically they can mimic melanocytic nevi or basal cell carcinomas (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that is useful in diagnosing melanocytic and non-melanocytic facial lesions. To date no studies have described the RCM features of facial angiofibromas. Herein, we present two cases of facial angiofibromas that were imaged with RCM and revealed tumor island-like structures that mimicked BCC, leading to skin biopsy.
Detection of Malignant Melanoma Using Artificial Intelligence: An Observational Study of Diagnostic Accuracy
Authors: Phillips Michael , Greenhalgh Jack , Marsden Helen , Palamaras Ioulios 
Published: June 2020

Background: Malignant melanoma can most successfully be cured when diagnosed at an early stage in the natural history. However, there is controversy over screening programs and many advocate screening only for high-risk individuals.
Objectives: This study aimed to evaluate the accuracy of an artificial intelligence neural network (Deep Ensemble for Recognition of Melanoma [DERM]) to identify malignant melanoma from dermoscopic images of pigmented skin lesions and to show how this compared to doctors’ performance assessed by meta-analysis.
Methods: DERM was trained and tested using 7,102 dermoscopic images of both histologically confirmed melanoma (24%) and benign pigmented lesions (76%). A meta-analysis was conducted of studies examining the accuracy of naked-eye examination, with or without dermoscopy, by specialist and general physicians whose clinical diagnosis was compared to histopathology. The meta-analysis was based on evaluation of 32,226pigmented lesions including 3,277 histopathology-confirmed malignant melanoma cases. The receiver operating characteristic (ROC) curve was used to examine and compare the diagnostic accuracy.
Results: DERM achieved a ROC area under the curve (AUC) of 0.93 (95% confidence interval: 0.92-0.94), and sensitivity and specificity of 85.0% and 85.3%, respectively. Avoidance of false-negative results is essential, so different decision thresholds were examined. At 95% sensitivity DERM achieved a specificity of 64.1% and at 95% specificity the sensitivity was 67%. The meta-analysis showed primary care physicians (10 studies) achieve an AUC of 0.83 (95% confidence interval: 0.79-0.86), with sensitivity and specificity of 79.9% and 70.9%; and dermatologists (92 studies) 0.91 (0.88-0.93), 87.5%, and 81.4%, respectively.
Conclusions: DERM has the potential to be used as a decision support tool in primary care, by providing dermatologist-grade recommendation on the likelihood of malignant melanoma.
Prevalence and Associations of General Practice Registrars’ Management of Impetigo: A Cross-Sectional Analysis From the Registrar Clinical Encounters in Training (ReCEnT) Study
Authors: Gorges Hilary , Heal Clare , Van Driel Mieke , Tapley Amanda , Davis Joshua , Davey Andrew , Holliday Elizabeth , Ball Jean , Najib Nashwa , Spike Neil , Fitzgerald Kristen , Magin Parker 
Published: June 2020

Background: Impetigo is a mild bacterial skin infection of childhood that is usually managed empirically in primary care.
Objective: To establish the prevalence and associations of impetigo in general practice (GP) registrars’ consultations.
Methods: Cross-sectional analysis of the Registrar Clinical Encounters in Training (ReCEnT) study data.
Results: Impetigo was managed in 0.24% of problems and 0.43% of consultations. Patient variables associated with impetigo presentations were younger age and impetigo as a new problem, while patients with non–English-speaking backgrounds were less likely to present with impetigo. Associated registrar variables were being new to the registrar and practicing in outer regional/remote locations. Compared with all other problems/diagnoses, impetigo more often involved information seeking, ordering pathology, and prescription of medication, but less often involved follow-up or referral.
Conclusions: Impetigo accounts for 0.43 per 100 GP registrar consultations in Australia. Association with outer regional/remote areas may reflect climate and socioeconomic factors that predispose to impetigo. Associated pathology requests may reflect a lack of confidence in GP registrars’ management of impetigo. Cultural differences may exist regarding health-seeking behavior relating to impetigo.
Las formas de organización y asociación de los trabajadores de empresas recuperadas en la Argentina (2000-2015).
Authors: Kasparian Denise 
Published: June 2020

En términos generales, las empresas recuperadas se basan en el trabajo asociativo y la propiedad conjunta de los medios de producción, por lo cual constituyen formas productivas no estructuradas a partir de relaciones asalariadas, en las cuales el trabajo se organiza a partir de patrones más horizontales y flexibles de relacionamiento, y la participación y la subjetividad de los trabajadores adquieren relevancia. El objetivo de este artículo es describir las formas de organización y asociación supra-unidad productiva que estos trabajadores sin patrón integraron y/o conformaron para la consecución de una multiplicidad de objetivos. El diseño metodológico es de corte cualitativo y triangula una serie de técnicas de investigación: entrevistas a informantes clave, análisis documental y de bibliografía sobre la temática, y búsqueda sistemática y análisis de artículos periodísticos sobre las acciones colectivas llevadas a cabo por organizaciones vinculadas al proceso de recuperación de empresas. Se observa que mientras que en un primer momento estos trabajadores crean organizaciones sociales que conforman un movimiento social, con la estabilización del proceso, dicho movimiento se fragmenta y da lugar a una convergencia cooperativa en organizaciones de segundo y tercer grado, al acercamiento sindical, y a la conformación de redes sectoriales. Hacia el final del período, se observa una incipiente revitalización del carácter movimentista de las organizaciones de empresas recuperadas.
Reseña de: Según Alonso, Manuel: La masonería madrileña en la primera mitad del siglo XX
Authors: Morales Ruiz Juan José 
Published: June 2020

Reseña de: Según Alonso, Manuel: La masonería madrileña en la primera mitad del siglo XX. Madrid, Sanz y Torres, 2019, 406 pp. ISBN: 978-84-17765-90-3.
Les usages des sites Web par les partis politiques camerounais
Authors: Oumarou Sali Bouba 
Published: June 2020

La présente note de recherche se propose de déterminer comment les partis politiques camerounais utilisent les sites Web afin de favoriser la participation politique des citoyens. Elle se fonde sur l’examen des sites Web de trois partis politiques camerounais représentés à l’Assemblée nationale : le Rassemblement démocratique du peuple camerounais (RDPC), l’Union démocratique du Cameroun (UDC) et le Mouvement pour la renaissance du Cameroun (MRC). Une étude comparative et fonctionnelle des sites de ces partis politiques est réalisée afin de voir comment ils exploitent cet espace virtuel de communication pour émuler l’engagement et la participation politique des citoyens camerounais.