bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoparticle-based vaccine development and evaluation against viral infections in pigs
Authors: Dhakal Santosh , Renukaradhya Gourapura J. 
Published: November 2019

AbstractVirus infections possess persistent health challenges in swine industry leading to severe economic losses worldwide. The economic burden caused by virus infections such as Porcine Reproductive and Respiratory Syndrome Virus, Swine influenza virus, Porcine Epidemic Diarrhea Virus, Porcine Circovirus 2, Foot and Mouth Disease Virus and many others are associated with severe morbidity, mortality, loss of production, trade restrictions and investments in control and prevention practices. Pigs can also have a role in zoonotic transmission of some viral infections to humans. Inactivated and modified-live virus vaccines are available against porcine viral infections with variable efficacy under field conditions. Thus, improvements over existing vaccines are necessary to: (1) Increase the breadth of protection against evolving viral strains and subtypes; (2) Control of emerging and re-emerging viruses; (3) Eradicate viruses localized in different geographic areas; and (4) Differentiate infected from vaccinated animals to improve disease control programs. Nanoparticles (NPs) generated from virus-like particles, biodegradable and biocompatible polymers and liposomes offer many advantages as vaccine delivery platform due to their unique physicochemical properties. NPs help in efficient antigen internalization and processing by antigen presenting cells and activate them to elicit innate and adaptive immunity. Some of the NPs-based vaccines could be delivered through both parenteral and mucosal routes to trigger efficient mucosal and systemic immune responses and could be used to target specific immune cells such as mucosal microfold (M) cells and dendritic cells (DCs). In conclusion, NPs-based vaccines can serve as novel candidate vaccines against several porcine viral infections with the potential to enhance the broader protective efficacy under field conditions. This review highlights the recent developments in NPs-based vaccines against porcine viral pathogens and how the NPs-based vaccine delivery system induces innate and adaptive immune responses resulting in varied level of protective efficacy.
Performance evaluation of the maximum complex correntropy criterion with adaptive kernel width update
Authors: Aquino Manoel B. L. , F. Guimarães João P. , Linhares Leandro L. S. , Fontes Aluísio I. R. , Martins Allan M. 
Published: November 2019

Abstract
The complex correntropy is a recently defined similarity measure that extends the advantages of conventional correntropy to complex-valued data. As in the real-valued case, the maximum complex correntropy criterion (MCCC) employs a free parameter called kernel width, which affects the convergence rate, robustness, and steady-state performance of the method. However, determining the optimal value for such parameter is not always a trivial task. Within this context, several works have introduced adaptive kernel width algorithms to deal with this free parameter, but such solutions must be updated to manipulate complex-valued data. This work reviews and updates the most recent adaptive kernel width algorithms so that they become capable of dealing with complex-valued data using the complex correntropy. Besides that, a novel gradient-based solution is introduced to the Gaussian kernel and its respective convergence analysis. Simulations compare the performance of adaptive kernel width algorithms with different fixed kernel sizes in an impulsive noise environment. The results show that the iterative kernel adjustment improves the performance of the gradient solution for complex-valued data.
Microbiome of vineyard soils is shaped by geography and management
Authors: Coller Emanuela , Cestaro Alessandro , Zanzotti Roberto , Bertoldi Daniela , Pindo Massimo , Larger Simone , Albanese Davide , Mescalchin Enzo , Donati Claudio 
Published: November 2019

Abstract

Background
Despite their importance as a reservoir of biodiversity, the factors shaping soil microbial communities and the extent by which these are impacted by cultivation are still poorly understood. Using 16S rRNA gene and ITS sequencing, we characterized the soil microbiota of vineyards and of neighboring permanent grassland soils in the Italian province of Trentino, and correlated their structure and composition to location, chemical properties of the soil, and land management.

Results
Bacterial communities had a core of conserved taxa accounting for more than 60% of the reads of each sample, that was influenced both by geography and cultivation. The core fungal microbiota was much smaller and dominated by geography alone. Cultivation altered the structure and composition of the soil microbiota both for bacteria and fungi, with site-specific effects on their diversity. The diversity of bacterial and fungal communities was generally inversely correlated across locations. We identified several taxa that were impacted by the chemical properties and texture of the soil.

Conclusions
Our results highlight the different responses of bacterial and fungal communities to environmental factors and highlight the need to characterize both components of the soil microbiota to fully understand the factors that drive their variability.
Seeing red: towards an improved protocol for the identification of madder- and cochineal-based pigments by fiber optics reflectance spectroscopy (FORS)
Authors: Fonseca Beatriz , Schmidt Patterson Catherine , Ganio Monica , MacLennan Douglas , Trentelman Karen 
Published: November 2019

Abstract
Fiber optics reflectance spectroscopy (FORS) is commonly used to non-invasively identify madder- and cochineal-based pigments on works of art, but the significant shifts sometimes observed in the position of their diagnostic absorption features can hinder correct interpretation of the spectra. To better understand these shifts, and improve the ability to confidently identify these pigments, a systematic study was carried out to evaluate the effects of different pigment recipes and laking substrates on reflectance spectra. Sixteen different madder- and cochineal-based pigments were synthesized using historical recipes. Each pigment, painted in four different binding media (gum Arabic, linseed oil, beeswax, and egg yolk), was fully characterized by FTIR and HPLC-DAD-MS prior to FORS measurements. The results of the study showed that, in contrast to the absorption features typically used for identification, features in the first derivative transformation of the FORS spectra provided a more robust means of primary identification. In addition, once it has been identified as cochineal, the absorption features in the spectra of cochineal-based pigments could be correlated to the recipe employed, providing a possible means for inferring the method of manufacture and laking substrate from a non-invasive analysis. The results of this study were used to create a decision tree for the identification of madder and cochineal pigments based solely on FORS.
Intraductal dissemination of ampullary carcinoma after pancreatoduodenectomy
Authors: Mohri Koichi , Hiramatsu Kazuhiro , Shibata Yoshihisa , Yoshihara Motoi , Aoba Taro , Arimoto Atsuki , Ito Akira , Kato Takehito 
Published: November 2019

Abstract

Background
Clinical evidence of intraductal dissemination through the pancreatic duct has been rare. We herein describe a case of ampullary carcinoma that disseminated in the remnant pancreas through the pancreatic duct.

Case presentation
A 68-year-old woman underwent SSPPD for ampullary carcinoma. The tumor was diagnosed as adenocarcinoma without lymph node metastasis (T2N0M0, stage IB). Computed tomography (CT) performed 3 years later revealed a 14-mm tumor near the site of the pancreaticojejunal anastomosis. Endoscopic ultrasound-guided fine needle aspiration showed adenocarcinoma that was morphologically similar to the specimen from the first surgery. We diagnosed recurrence of ampullary carcinoma in the remnant pancreas. A total remnant pancreatectomy was performed. We found a white solid tumor at the 20-mm distal side of pancreaticojejunal anastomosis. The tumor was morphologically similar and immunostaining showed a pattern identical to that of the original tumor, suggesting that the two tumors were of the same origin.

Conclusion
The recurrent lesion was most likely the result of tumor cells leaving the tumor and implanting in the remnant pancreatic duct epithelium. Intraductal dissemination of adenocarcinoma is thought to be a cause of remnant recurrence after SSPPD in cases of obstruction of the pancreatic duct or an iatrogenic procedure.
Implementation of mifepristone medical abortion in Canada: pilot and feasibility testing of a survey to assess facilitators and barriers
Authors: Devane Courtney , Renner Regina M. , Munro Sarah , Guilbert Édith , Dunn Sheila , Wagner Marie-Soleil , Norman Wendy V. 
Published: November 2019

Abstract

Background
Direct primary care provision of first-trimester medical abortion could potentially address inequitable abortion access in Canada. However, when Health Canada approved the combination medication Mifegymiso® (mifepristone 200 mg/misoprostol 800 mcg) for medical abortion in July 2015, we hypothesized that the restrictions to distribution, prescribing, and dispensing would impede the uptake of this evidence-based innovation in primary care. We developed and pilot-tested a survey related to policy and practice facilitators and barriers to assess successful initiation and ongoing clinical provision of medical abortion service by physicians undertaking mifepristone training. Additionally, we explored expert, stakeholder, and physician perceptions of the impact of facilitators and barriers on abortion services throughout Canada.

Methods
In phase 1, we developed a survey using 2 theoretical frameworks: Greenhalgh’s conceptual model for the Diffusion of Innovations in health service organizations (which we operationalized) and Godin’s framework to assess the impact of professional development on the uptake of new practices operationalized in Légaré’s validated questionnaire. We finalized questions in phase 2 using the modified Delphi methodology. The survey was then tested by an expert panel of 25 nationally representative physician participants and 4 clinical content experts. Qualitative analysis of transcripts enriched and validated the content by identifying these potential barriers: physicians dispensing the medication, mandatory training to become a prescriber, burdens for patients, lack of remuneration for mifepristone provision, and services available in my community. To assess the usability and reliability of the online survey, in phase 3, we pilot-tested the survey for feasibility.

Results
We developed and tested a 61-item Mifepristone Implementation Survey suitable to study the facilitators and barriers to implementation of mifepristone first-trimester medical abortion practice by physicians in Canada.

Conclusions
Our team operationalized Greenhalgh’s theoretical framework for Diffusion of Innovations in health systems to explore factors influencing the implementation of first-trimester medical abortion provision. This process may be useful for those evaluating other health system innovations. Identification of facilitators and barriers to implementation of mifepristone practice in Canada and knowledge translation has the potential to inform regulatory and health system changes to support and scale up facilitators and mitigate barriers to equitable medical abortion provision.
The relative importance of competition to contagion: evidence from the digital currency market
Authors: Xie Peng , Wu Jiming , Du Hongwei 
Published: November 2019

AbstractHow does the valuation change of an industry leader influence its competitors? Does it induce a competitive effect or a contagion effect? What are the driving forces of such influences? We attempted to answer these questions within digital currency markets. We found that both close and distant competitors against an industry leader experience high competitive effects, while moderate competitors experience high contagion effects. Next, we empirically demonstrated how this U-shaped pattern reduces to a linear relationship depending on the industry concentration. Lastly, we identified eight distinct information categories from a social media platform of the industry leader and compared the influence of the eight information categories on the industry leader’s competitors. Our analysis suggests that the relative importance of the competitive effect to the contagion effect in the industry depends on the category of the information.
Reply to discussions by Zavala (2019) and by Van Loon, Hüeneke, and Mulder (2019) on Shanmugam, G. (2018, Journal of Palaeogeography, 7 (3): 197–238): ‘the hyperpycnite problem’
Authors: Shanmugam G. 
Published: November 2019

AbstractIn this reply, I respond to 18 issues associated with comments made by Zavala (e.g., inverse- to normally-graded sequence, origin of massive sands, experimental sandy debris flows, tidal rhythmites, facies models, etc.), and 10 issues associated with comments made by Van Loon et al. (e.g., 16 types of hyperpycnal flows, anthropogenic hyperpycnal flow, etc.).
Long-Term Outcomes of Treatments for Central Precocious Puberty or Early and Fast Puberty in Chinese Girls
Authors: Fu Junfen , Zhang Jianwei , Chen Ruimin , Ma Xiaoyu , Wang Chunlin , Chen Linqi , Liang Yan , Luo Xiaoping , Yang Yu , Xiong Feng , Su Zhe , Wu Jing , Yao Hui , Xu Jinliang , Wu Di , Ni Yan 
Published: November 2019

Abstract

Context
Gonadotropin-releasing hormone analogues (GnRHa) and recombinant human growth hormone (rhGH) have been widely used to treat idiopathic central precocious puberty (CPP) or early and fast puberty (EFP). However, large-scale studies to evaluate the treatment effects on final adult height (FAH) are still lacking.

Objective
To assess the effects of long-term treatment for CPP/EFP on FAH and its main influencing factors.

Design and Setting
Retrospective, multicenter observational study from 1998 to 2017.

Participants
Four hundred forty-eight Chinese girls with CPP/EFP received GnRHa and rhGH treatment (n = 118), GnRHa alone (n = 276), or no treatment (n = 54).

Main Outcome Measures
FAH, target height (Tht), and predictive adult height (PAH).

Results
The height gain (FAH–PAH) was significantly different among the GnRHa and rhGH treatment, GnRHa alone, and no treatment groups (P &lt; 0.05; 9.51 ± 0.53, 8.07 ± 0.37, and 6.44 ± 0.91 cm, respectively). The genetic height gain (FAH–Tht) was 4.0 ± 0.5 cm for the GnRHa + rhGH group and 2.0 ± 0.27 cm for the GnRHa group, while the control group reached their Tht. In addition, 5 critical parameters derived from PAH, bone age, and Tht, showed excellent performance in predicting which patients could gain ≥5 cm (FAH–PAH), and this was further validated using an independent study.

Conclusions
The overall beneficial effect of GnRHa + rhGH or GnRHa on FAH was significant. The control group also reached their genetic target height. Clinicians are recommended to consider both the potential gains in height and the cost of medication.
PERCOBAAN PENGISIAN-PENGELUARAN HIDROGEN SEBUAH TANGKI SIMPAN HIDROGEN PADAT[Research of Charging-Discharging Hydrogen of Solid Hyrogen Storage Tan]
Authors: Suwarno Hadi 
Published: November 2019

Intisari Menyimpan hidrogen dalam bentuk padat sebagai paduan metal hidrid merupakan metoda baru untuk keperluan bahan bakar kendaraan transportasi karena memiliki densitas yang lebih besar. Sebuah tangki simpan hidrogen dengan volume sekitar 1 liter berisi serbuk nano partikel Mg2Ti5Fe6 sekitar 700 gram telah dirakit menjadi satu kesatuan dan diuji unjuk kerjanya serta dibandingkan dengan tangki kosong bervolume yang sama. Pengisian dan pengeluaran hidrogen ke dalam/luar tangki dilakukan pada suhu kamar dengan tekanan bervariasi 2, 6,5, dan 8 bar. Dari hasil percobaan diperoleh bahwa rasio kapasitas serapan hidrogen tangki berisi serbuk nano partikel Mg2Ti5Fe6 terhadap tangki kosong berturut-turut 1,3, 2,3, dan 2,8. Percobaan serapan hidrogen pada tekanan lebih tinggi tidak dapat dilakukan karena keterbatasan sarana, namun apabila tekanan dalam tangki diperbesar, maka kapasitas serapan hidrogen masih akan bertambah. Dari penelitian ini ditunjukkan bahwa percobaan awal penyimpanan-pengeluaran hidrogen padat dari tangki telah berhasil baik. Penelitian lanjutan dalam bentuk pemanfaatannya di fuel cell sedang direncanakan.Kata kunci: Nano Partikel, Metal hidrid, Hydrogen Storage, Pengisian-pengeluaran. Abstract Storing hydrogen in the form of metal-hydride is one of the most promising fuels for transport vehicles because of its high gravimetric density. A solid hydrogen storage tank with the volume of tank about one liter containing about 700 g of nano powders Mg2Ti5Fe6 alloy has been fabricated for performing the hydrogen charging-discharging cycles. Charging-discharging of hydrogen into/out from the tank is conducted at room temperature at the varied pressure of 2, 6.5 and 8 bars. It is exhibited that the ratio of hydrogen capacity of the tank containing Mg2Ti5Fe6 nano particle to the empty tank is 1.3, 2.3, and 2.8, respectively. Charging experiment at higher pressure could not be conducted due to the limit of facility. It is predicted that at higher pressure the hydrogen capacity of the tank will be increased. From the experimental results it is concluded that the preliminary study on charging-discharging solid state hydrogen has been done successfully. Further examination in the form of its application in the fuel cell is being scheduled. Keyword: Nano Particle, Metal hydrid, Hydrogen Storage, Charging-discharging.
VOLUNTARIOS CONTRA LA REPÚBLICA: EL REQUETÉ ALAVÉS
Authors: RUIZ LLANO GERMÁN 
Published: November 2019

En la década de los años 30 del siglo XX, Álava era una provincia española mayoritariamente agrícola y con una población profundamente católica, con una escasa violencia sociopolítica y altos niveles de distribución de la propiedad. Sin embargo, en julio de 1936, se convirtió en una de las provincias con un mayor porcentaje de población masculina alistada voluntariamente para combatir contra la II República. El porqué y el cómo de aquella parte de la movilización antirrepublicana, proveniente sobre todo del mundo rural tradicional, centran el presente artículo.
O MOVIMENTO ESTUDANTIL UNIVERSITÁRIO NO BRASIL: ENTRE A LUTA PELA REFORMA UNIVERSITÁRIA E A RESISTÊNCIA À DITADURA (1960-1968)
Authors: FREITAS BRITO ANTÔNIO MAURÍCIO 
Published: November 2019

O artigo discorre sobre a atuação do movimento estudantil universitário nos anos 1960. Apresenta as principais pautas de mobilização do início da década, especialmente a luta pela reforma universitária. Explora o impacto repressivo do golpe de 1964 para o movimento estudantil. Demonstra o apoio de setores universitários à queda de Goulart ressaltando a importância de pesquisas sobre organizações estudantis anticomunistas. Discute a reorganização de uma ação estudantil em oposição ao regime militar tendo seu ápice em 1968. Sublinha a reação governamental inspirada no anticomunismo e a escalada repressiva até a edição do Ato institucional no. 05. Levanta algumas questões historiográficas sobre o movimento estudantil no Brasil.
Acknowledgements
Authors: Papier Joy 
Published: November 2019

The Journal of Vocational, Adult and Continuing Education and Training could not have become a reality without the commitment of a number of individuals and organisations who provided support at critical stages of its development.

We are grateful for the vision of the University of the Western Cape Faculty of Education, especially that of the former Dean of Education, Prof. Zubeida Desai, for her enthusiasm for this venture.

We thank the Education Policy Consortium (EPC) for its initial seed funding grant which enabled the scoping research and the journal development workshop in 2016.

The encouragement of members of the Department of Higher Education and Training in the early phase of conceptualisation of the journal is gratefully acknowledged.

Our appreciation also goes to the MerSETA for their strategic partnership in this initiative and for making a consistent contributution towards developing TVET scholarship.

The publication of this issue of the journal has been made possible by the Teaching and Learning Development Capacity Improvement Programme which is being implemented through a partnership between the Department of Higher Education and Training and the European Union.

We are enormously grateful to our colleagues across the spectrum of post-school provision, who offered helpful advice as the journal processes unfolded.

Thank you to the authors who allowed us to subject their work to scrutiny and for being willing to publish in the JOVACET.

Our reviewers, who gave so generously of their time and talent, deserve a special word of thanks.

Thank you to our Editorial Committee and Advisory Board – we look forward to your continued participation and support.
Une critique furtive de l’État social
Authors: Tabin Jean-Pierre , Leresche Frédérique 
Published: November 2019

Dans cet article, nous partons d’un angle mort de la théorie de la construction des problèmes sociaux, celui de la résistance des publics à la définition institutionnalisée des problèmes et de leurs solutions. Nous montrons d’abord que la positivité des droits sociaux pour leurs publics potentiels a un caractère hégémonique. Puis nous examinons les recherches existantes sur le non-recours aux droits sociaux pour indiquer qu’il n’est pas toujours, ou pas seulement dû à des dysfonctionnements administratifs, à un manque d’habileté sociale ou à des processus de stigmatisation sociale, il peut être une réaction au pouvoir de l’État. Ce type de non-recours repose sur une critique que nous qualifions de « furtive » en raison du caractère hégémonique de la positivité des droits sociaux. Comme piste pour l’étudier, nous proposons de mobiliser des outils inspirés des perspectives anthropologiques subalterne, postcoloniale et décoloniale.
Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line
Authors: Al-romaizan Abeer N. , Jaber Thoraya S. , Ahmed Nesreen S. 
Published: November 2019

AbstractA series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an in vitro evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds 3f, 6f, 8c, and 10b showed IC50 values (6.53, 7.88, 7.89, 7.79 μM, respectively) compared to that of the mentioned drug staurosparine (IC50 = 4.51 μM). On the other hand, derivatives 10c, 8d, 4d, 10f and 8b displayed better activity than staurosporin with IC50 values (1.47, 1.62, 1.68, 2.30, 3.19 μM, respectively).