bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Approach for Three-Dimensional Evaluation of Reduction Morphology in Distal Radius Fracture
Authors: Yoshii Yuichi , Eda Yusuke , Asai Reo , Ikumi Akira , Totoki Yasukazu , Kohyama Sho , Ogawa Takeshi 
Published: December 2024

Abstract

Background
Distal radius fractures are among the most common fractures, traditionally evaluated using two-dimensional (2D) parameters. These methods are unreliable in significantly displaced fractures, with discrepancies among evaluators. Recent advancements in imaging have introduced three-dimensional (3D) models, but standard parameters for 3D reduction morphology are not well established. This study aimed to develop a novel method for evaluating 3D reduction morphology based on the normal vector of a plane defined by anatomical reference points, comparing the reduction shape to the mirror image of the unaffected contralateral side.
Methods
This retrospective case-control study included 27 patients (mean age 67.6 years) who underwent osteosynthesis with a volar locking plate for distal radius fractures. Preoperative and postoperative computed tomography (CT) scans of the affected and unaffected wrists were analyzed using 3D image analysis software. The 3D coordinates of three reference points; (1) radial styloid process, (2) sigmoid notch volar edge, and (3) sigmoid notch dorsal edge, were used to evaluate the reduction shape and compare it to the unaffected side mirror image. Correlations between vector angles in the coronal, sagittal, and axial planes and clinical outcomes, such as % total active motion (%TAM) and Mayo wrist scores, were analyzed.
Results
The distances between the unaffected mirror image and postoperative image for the three reference points were 2.1 mm, 2.1 mm, and 2.7 mm, with barycenter differences of 1.7 mm. The postoperative plane areas consisted from three reference points were significantly larger in the postoperative image compared to the unaffected mirror image (203.4 mm² vs. 192.4 mm², P < 0.01). Correlation coefficients for vector angles in the yz-plane between unaffected mirror image and postoperative image were moderate (0.53, P < 0.05). Mild correlations were found between postoperative vector angles in the xy and xz planes and %TAM.
Conclusions
This novel 3D evaluation method provides a more comprehensive assessment of fracture reduction, particularly in the axial plane. While it demonstrates good reproducibility in coronal alignment, further refinement is needed for sagittal and axial alignments. This method could enhance surgical precision and improve clinical outcomes in distal radius fracture management.
Clinical trial number:
not applicable.
Effect of potent nucleos(t)ide analog on alpha fetoprotein changes and occurrence of hepatocellular carcinoma in patients with chronic hepatitis B
Authors: Ma Qianqian , Ye Junzhao , Luo Ling , Sun Yanhong , Wang Wei , Feng Shiting , Liao Bing , Zhong Bihui 
Published: December 2024

Abstract

Background
Successful antiviral therapy significantly decreases the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Alpha-fetoprotein (AFP) in the serum is a valuable early indicator of HCC. However, it is unclear whether different antiviral medications have varying effects on AFP levels. The purpose of this study was to evaluate this issue in those treated with entecavir (ETV) versus tenofovir disoproxil fumarate (TDF).
Methods
We prospectively enrolled treatment-naive CHB adults who commenced treatment with ETV or TDF. Their changes in biochemical, virological, and fibrosis parameters and the elevation of AFP or development of HCC during follow-up were analyzed.
Results
A total of 1942 CHB patients were included (10% ~ 90% follow-up time 3 ~ 60 months), and 104 patients with elevated AFP (5.3%) and 27 patients with HCC development (1.4%) were identified during the follow-up. The difference in the cumulative incidence of AFP abnormalities and HCC was statistically significant between patients who received ETV or TDF therapy. Multivariate Cox regression showed that elevated liver stiffness with shear wave elastography (Hazard ratio (HR) = 1.05, 95% Confidence interval (CI): 1.03 ~ 1.08, P < 0.001) and abnormal AFP at baseline (HR = 1.00, 95% CI: 1.00 ~ 1.00, P < 0.001) were independent risk factors for abnormal AFP in CHB patients, while shear wave elastography (HR = 1.07, 95% CI: 1.02 ~ 1.12, P < 0.001) was also independent risk factor for HCC. The combination of shear wave elastography (SWE), mPage-B score, age and type 2 diabetes mellitus had an area under the curve of 0.838 (P < 0.001) in predicting the occurrence of HCC.
Conclusions
Similar AFP elevation and HCC development rates were observed in CHB patients treated with ETV or TDF. Elevated SWE and abnormal AFP at baseline were independent risk factors for abnormal AFP in CHB patients.
Chlormethine Gel Effectiveness as second-line Treatment in Mycosis fungoides: a single- centre Retrospective Study
Authors: Zengarini Corrado , Guglielmo Alba , Vocale Ludovica , Filippini Andrea , Bardazzi Federico , Morsia Erika , Neri Iria , Mussi Martina , Piraccini Bianca Maria , Pileri Alessandro 
Published: December 2024

Abstract

Background: Chlormethine gel is a promising treatment for early-stage mycosis fungoides (MF) with strong efficacy and manageable side effects. This study evaluates its effectiveness as a second-line treatment in patients unresponsive to prior skin-directed therapies (SDTs) or combined systemic treatments, hypothesising significant therapeutic benefits with manageable adverse reactions.
Methods: A retrospective observational study was conducted from April 2021 to December 2022, including adult patients with histologically confirmed MF who had not responded to at least one prior SDT. Patients received daily chlormethine gel applications, and responses were evaluated at 3, 6, and 12 months using the Modified Severity-Weighted Assessment Tool (mSWAT). Statistical analyses were performed using SPSS ver 26 (IBM), including one-way ANOVA and univariate regression.
Results: The study included 21 patients (12 males, 9 females; mean age 61 years). 81% had early-stage MF, and 19% had advanced-stage disease. Chlormethine gel showed a 90% response rate, with 33.3% achieving complete response (CR) and 57.1% partial response (PR). Adverse reactions were primarily contact or irritative dermatitis, which were manageable and did not significantly affect outcomes. Median mSWAT scores significantly reduced from baseline at 3, 6, and 12 months (P=0.002).
Conclusions: Chlormethine gel appeared to be efficacious and safe as a second-line treatment for MF, including in advanced stages. Despite limitations like small sample size and retrospective design, these findings highlight its potential in combination therapies and the importance of continued treatment for optimal outcomes. Future research should confirm these results in larger, prospective studies.
The importance of age as a prognostic predictor of childhood hepatoblastoma: an analysis of single-center childhood hepatoblastoma in China
Authors: Li Zhen , Jiang Hong , Wang Yuan-Qi , Wang Wen-Qing , Huang Li-Bin , Liu Jun-Cheng , Xue Hong-Man 
Published: December 2024

Abstract

Objective This study aimed to examine how age at first diagnosis influences the prognosis of Chinese children with hepatoblastoma (HB), and to offer insights for enhancing HB risk stratification.
Methods Data from 403 patients with HB diagnosed at the First Affiliated Hospital of Sun Yat-sen University between February 2010 and September 2023 were collected. Kaplan‒Meier survival analysis, Cox regression analysis, and binary logistic regression were employed for statistical analysis.
Results The hazard ratios (HRs) for event-free survival (EFS) reduction in HB patients were 1, 0.862, 1.393, 2.008, 1.325, 1.859, 3.667 (P=0.001), and 2.502 (P=0.023) for first–diagnosis ages of 0–1, 1–2, 2–3, 3–4, 4–5, 5–6, 6–8, and ≥8 years, respectively, and the HRs for overall survival (OS) were 1, 0.410, 0.876, 1.713, 1.243, 0.575, 3.012 (P=0.039), and 2.012, respectively. After adjusting for newly diagnosed alpha-fetoprotein (AFP), pretreatment extent of tumor (PRETEXT) stage, and PRETEXT stage annotation factors, the prognosis of HB for patients diagnosed at ≥6 years old and <6 years old remained significantly different. There was no significant difference in the HR for EFS or OS reduction among the 0–1month, 1–3month, 4–6month, 7–9month, and 9–12month groups.
Conclusion Age≥6 years is an independent risk factor for poor prognosis in HB patients. Age has no effect on the prognosis of HB during infancy. The inclusion of patients aged ≥6 years at first diagnosis in the high-risk group for risk stratification was deemed appropriate. This age factor can guide adjustments in chemotherapy intensity.
Exploring Clinical and Urinary Factors in Treatment-Resistant vs. Treatment-Responsive Childhood Enuresis: A Comparative Study
Authors: Lorestani Parsa , Khodadadiyan Alireza , Kaviari Mohammad Amin , Montazeri Alireza , Golmoradi Hadi , Lorestani Amir Mohammad , Tohidi Mohamad Reza 
Published: December 2024

Abstract

Background
Nocturnal enuresis is a common pediatric condition affecting 7.61–18.7% of school-aged children. While various treatment options exist, resistance to treatment presents a significant clinical challenge. This study aimed to identify factors distinguishing treatment-resistant from treatment-responsive cases of childhood enuresis.
Methods
A cross-sectional analytical study was conducted in 2017 at Mohammad Kermanshahi Hospital, Iran. The study included 144 children aged 5–8 years with nocturnal enuresis, divided into treatment-controlled (n = 85) and treatment-resistant (n = 59) groups. Participants received Desmopressin nasal spray (DDAVP) at 10 mcg/spray nightly. Demographics, clinical characteristics, sleep patterns, urination habits, and ultrasound findings were analyzed.
Results
Several factors were significantly associated with treatment resistance, including multiple bedwetting episodes per night (64.4% vs 28.2%, p < 0.001), abnormal residual urine volume (61.0% vs 31.8%, p < 0.001), and large urine volume per episode (86.4% vs 61.2%, p = 0.001). Logistic regression identified five independent predictors of treatment resistance: nightly bedwetting (OR = 4.82), large urine volume per episode (OR = 3.97), abnormal residual urine volume (OR = 3.35), multiple bedwetting episodes per night (OR = 2.89), and urinary urgency (OR = 2.14).
Conclusion
Treatment-resistant nocturnal enuresis is associated with specific urinary patterns and bladder dysfunction characteristics. These findings may help clinicians identify patients at risk for treatment resistance and develop targeted therapeutic strategies. Further research with extended follow-up periods is recommended to validate these findings.
Hospital-Acquired Infections in Neonatal Intensive Care Unit, Gondar, Ethiopia: A Prospective Follow-Up Study
Authors: Debie Getnet , Bayu Geta , Kokeb Mehretie 
Published: December 2024

Abstract

Background
Hospital-acquired infections in neonates are common problems with significant effect on neonatal morbidity and mortality. The incidence rates of hospital-acquired infections in neonates are variable and dependent on factors such as the hospital's infection control measures, neonatal intensive care unit (NICU) protocols, and the prevalence of pathogens in the hospital environment. However, little is known about incidence and associated factors in Ethiopia, which was the main aim of our study.
Methods
A prospective follow-up study was conducted to assess the incidence and associated factors of hospital-acquired infections in neonates admitted to the neonatal intensive care unit of the University of Gondar Hospital from September 1st, 2023, to February 29th, 2024. All neonates admitted to the Neonatal ICU who stayed for ≥ 48 hours were included in the study and participants were selected by systematic random sampling. To identify contributors to HAIs, both bivariate and multivariate Cox regression analyses were applied, and P < = 0.05 was considered statistically significant for association.
Results
A total of 247 neonates were followed for 2145 patient days. The incidence rate of hospital-acquired infection was 18.2 (95% CI: 11.3–20.3) per 1000 neonatal days of follow-up, and the overall cumulative incidence was 15.8%. Neonates who stayed longer than 7 days (p = 0.041), used CPAP (p = 0.003), and urinary catheter (p = 0.001) were found to have significant risks of developing HAIs.
Conclusion
The incidence of hospital-acquired infections was high, and the presence of invasive medical devices and longer stays in the hospital were significantly associated with an increased risk of HAI in the NICU.
Roles of skin microbiota in hidradenitis suppurativa: insights from a two-sample Mendelian randomization analysis
Authors: Yu Chenyang , Yan Wei , Shucheng Huidi , Huang Yingzhao , Jiang Xian 
Published: December 2024

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with unique lesional dysbiotic features. However, the role of the microbiology in the pathogenesis of HS remains in dispute. We aimed to conduct a two-sample Mendelian randomization study to investigate the relationship between skin microbiota and HS. A two-sample Mendelian randomization study was performed using the summary statistics of skin microbiota from summary GWAS data of the European descent from two cross-sectional, population-based German cohorts, KORA FF4 (n = 324) and PopGen (n = 273). The summary statistics of hidradenitis suppurativa were obtained from the FinnGen DF10 (1,070 cases and 394,105 controls). Inverse variance weighted (IVW), MR-Egger regression, weighted median, simple mode, weighted mode, and MRPRESSO were used to examine the causal association between skin microbiota and hidradenitis suppurativa. Cochran’s Q statistics were used to quantify the heterogeneity of instrumental variables. Our study suggested that genus Corynebacterium in dry skin is significantly associated with HS after false discovery rate (FDR) correction (odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02–1.06, P = 0.0002, FDR adjusted P = 0.035). Additionally, we found genus Micrococcus in moist skin (OR = 1.10, 95% CI: 1.03–1.18, P = 0.0060, FDR adjusted P = 0.360), species Streptococcus salivarius in dry skin (OR = 1.03, 95% CI: 1.01–1.05, P = 0.0070, FDR adjusted P = 0.360), and species Propionibacterium granulosum (OR = 1.02, 95% CI: 1.00–1.04, P = 0.0460, FDR adjusted P = 0.970) are potentially associated with HS before FDR adjustment. No evidence of the effect in the reverse direction for HS on skin microbial features. This two-sample Mendelian randomization study found that genus Corynebacterium was causally associated with HS. Further studies are needed to clarify the protective effect of probiotics on hidradenitis suppurativa.
Impact of Enhanced Chest CT with three-dimensional Reconstruction Combined with Preoperative Olive Oil Administration on the Incidence of Postoperative Chylothorax: A Retrospective Study
Authors: Luo Xindong , Lu Di , Wang Ziqiang , Wang Jingyi , Dong Ruozhu , Wang Yaping , Cao Wei , Jin Dacheng , Lin Zhaohao , Li Haochi , Du Pengcheng , Gou Yunjiu , Dong Pengcheng , Yang Yayuan 
Published: December 2024

Abstract

Background
Chylothorax, a rare yet potentially fatal complication, may arise following esophageal cancer resection. The objective of this study is to assess the effectiveness of a combined approach involving enhanced chest CT with three-dimensional(3D) reconstruction and preoperative olive oil administration in mitigating the risk of chylothorax after esophageal cancer surgery.
Methods
A retrospective analysis was performed on the clinical records of 357 patients who underwent esophageal cancer resection at the Department of Thoracic Surgery, Gansu Provincial People's Hospital, between January 2019 and June 2024. The patients were divided into two groups: 179 received preoperative enhanced chest CT with 3D reconstruction and oral olive oil (3D reconstruction Group), while 158 served as the control group without these interventions. The primary endpoints included the incidence of chylous leakage and associated perioperative outcomes.
Results
All patients in both groups had successful surgeries without any perioperative fatalities. Notably, the 3D reconstruction Group exhibited a significantly lower incidence of postoperative chylothorax compared to the control group (0% vs. 8.2%, P ≤ 0.001). Furthermore, the 3D reconstruction Group experienced reduced intraoperative bleeding (P = 0.003), shorter postoperative hospital stays (P = 0.003), and decreased thoracic drainage on the third postoperative day (P < 0.001).
Conclusion
The integration of preoperative enhanced CT with 3D reconstruction and oral olive oil administration facilitates personalized surgical planning for esophageal cancer resection. This approach enhances the visualization of the thoracic duct during surgery and effectively reduces the incidence of postoperative chylothorax, highlighting its promising clinical utility.
A high-quality and prolonged cardiopulmonary resuscitation after cardiac arrest in a spinal endoscopic surgery: a case report
Authors: Wang Qiong , Lu Bin 
Published: December 2024

Abstract

Background: There are many reasons for perioperative cardiac arrest, and early identification, rapid diagnosis, and effective resolution of the etiology can generally lead to treatment for patients. However, for patients with unexplained cardiac arrest or those who have undergone prolonged cardiopulmonary resuscitation, how anesthesiologists can effectively rescue them and improve the quality of their recovery is a question worth considering.
Case presentation: The patient was a 50-year-old man with a cervical spondylotic radiculopathy. He was scheduled for cervical discectomy under spinal endoscopy under general anesthesia. We performed routine anesthesia induction and monitor. Half an hour after the operation, the patient had sudden cardiac arrest and then we immediately performed cardiopulmonary resuscitation. At the same time, we also performed physical examination on the patient and placed an esophageal ultrasound probe, hoping to find out possible causes such as anaphylactic shock, pulmonary embolism, cardiac tamponade, etc. Although we did not find the exact etiology finally, we continued to perform high-quality cardiopulmonary resuscitation for up to 90 minutes and never stopped rescuing the patient. Fortunately, the patient returned to spontaneous circulation, and he was discharged after about a month of treatment and rehabilitation. After one year of follow-up, the patient still had no sequelae and resumed daily activities.
Conclusions: We want to express that not all cardiac arrest can be explained in a limited time, especially in complex surgical procedures. But early identification of cardiac arrest and adherence to high-quality cardiopulmonary resuscitation can increase survival rates to a certain extent and improve the prognosis of patients.
A simple pathway for the preparation of an environmentally and high performance glyoxal-based adhesive for plywood
Authors: Liu Guowei , Zhang Xin , Wang Hongyan , Liao Jingjing , Wang Hui , Zhou Xiaojian 
Published: December 2024

Abstract

The use of glyoxal to replace formaldehyde for preparing wood adhesive was considered as an effective way to address formaldehyde issue. However, the properties of glyoxal-based resins via continent preparation process were poor, especially the water resistance was pretty low compared with the formaldehyde-based resins. Here, a new glyoxal-polyvinylamine-urea (GPU) copolymer resin with excellent water resistance was presented in this work by using polyvinylamine(PVAm) as a modifier agent to enhance the performance of glyoxal based resins. The bonding strength and water resistance of this new glyoxal-based resin were evaluated via measuring mechanical property of three-plywood produced in our laboratory. The structural features of this resin were characterized by FT-IR, ESI-MS, their curing and thermal behavior were also explored. This resin has a fast curing rate and good thermal stability, and the best dry bonding strength of plywood was 2.37MPa, and the wet bonding strength was 1.10MPa and 0.71MPa after immersed in cold water for 24h and 63 ℃ hot water for 3h, respectively. The enhanced water resistance can be explained by the formation of a better cured resin network verified from the FT-IR, ESI-MS spectroscopy analyses.
Identifying the water quality of temperate Polish lakes based on major abiotic parameters and indicator phytoplankton assemblages
Authors: Aykut Tumer Orhun , Rudak Agnieszka , Crucitti-Thoo Robin Michael , Jasser Iwona 
Published: December 2024

Abstract

The investigation conducted in Northeastern Poland aimed to determine the water quality of twenty-five lakes based on leading environmental drivers and indicator phytoplankton species. Water and phytoplankton samples were collected between the 13th and 28th of August, 2023. To evaluate the water quality, the Weighted Arithmetic Water Quality Index (WAWQI), Comprehensive Pollution Index (CPI), and Carlson’s Trophic State Index (TSI) were chosen as appropriate indexes. The minimum values of WAWQI and CPI were observed in ST22 (Lake Wigry) and ST18 (Lake Hańcza) while the highest ones were in ST16, ST1, and ST2, (Rekąty, Suskie, and Piłag) respectively. TSI values were also the lowest in ST18 and the highest in ST10. Pediastrum was the most abundant genus throughout the study. However, on a species level, C. hirundinella and P. boryanum were observed as the most dominant species, reaching the highest biomass in six lakes. According to WAWQI, three lakes were classified as "extremely poor", three as very poor and the rest as poor Based on the results of CPI, four lakes belonged to the "slightly polluted", three to "clean", and the rest to "sub-clean", with non of the lakes classified as medium or heavily polluted. The water quality in the region is declining as a result of tourism and developmental activities. Therefore, this work is expected to contribute to upcoming water management activities. Moreover, based on Carlson's Trophic State Index (TSI) most of the lakes belong to class III (mesotrophic) (10) and IV (eutrophic) (9).
EEG-Based Alzheimer's Detection Using Power Spectral Density, Tsallis Entropy, Amplitude Features, and SVM Classification
Authors: Cisse Ayat , Farahat Zineb , Zrira Nabila , Benmiloud Ibtissam , Abdi Bahia El , Ngote Nabil 
Published: December 2024

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease of brain tissue, currently incurable, which leads to the progressive and irreversible loss of mental functions, particularly memory. It is rare to detect Alzheimer to an early stage. However, early diagnosis can allow a faster treatment and thus improve the patient's well-being. Electroencephalogram (EEG) is a non-invasive and cost-effective tool that measures electrical activity in the brain. In this study, we aimed to create an automatic detection method by combining several powerful EEG biomarkers which, to our knowledge, were never put together namely Power Spectral Density, Tsallis entropy and changes in the EEG amplitude. The features were then put into a Support Vector Machine (SVM) for the identifications of Alzheimer patients and healthy controls (CN). Using a five-fold cross-validation strategy across the entire frequency band, the classification accuracy reached 83.08%, with a sensitivity of 78% and a specificity of 90% while it reached 78.46% accuracy ,75% sensitivity and 83% specificity using the leave one subject out cross validation.