bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel processing of sensory cue and spatial information in the Dentate Gyrus
Authors: Tuncdemir Sebnem N. , Grosmark Andres D. , Turi Gergely F. , Shank Amei , Bowler Jack , Ordek Gokhan , Losonczy Attila , Hen Rene , Lacefield Clay 
Published: February 2020

AbstractDuring exploration, animals form an internal map of an environment by combining information about specific sensory cues or landmarks with the animal’s motion through space, a process which critically depends on the mammalian hippocampus. The dentate gyrus (DG) is the first stage of the hippocampal trisynaptic circuit where self-motion and sensory cue information are integrated, yet it remains unknown how neurons within the DG encode both cue related (“what”) and spatial (“where”) information during cognitive map formation. Using two photon calcium imaging in head fixed mice running on a treadmill, along with on-line sensory cue manipulation at specific track locations, we have identified robust sensory cue responses in DG granule cells largely independent of spatial location. Granule cell cue responses are stable for long periods of time, selective for the modality of the stimulus and accompanied by strong inhibition of the firing of other active neurons. At the same time, there is a smaller fraction of neurons whose firing is spatially tuned but insensitive to the presentation of nearby cues, similar to traditional place cells. These results demonstrate the existence of “cue cells” in addition to the better characterized “place cells” in the DG, an important heterogeneity that has been previously overlooked. We hypothesize that the granule cell population may support multiple channels of spatial and non-spatial information that contribute distinctly to local and down-stream computations and impact the role of the dentate gyrus in spatial navigation and episodic memory.
The BRPF1 bromodomain is a molecular reader of di-acetyllysine
Authors: Obi Juliet O. , Lubula Mulu Y. , Cornilescu Gabriel , Henrickson Amy , McGuire Kara , Evans Chiara M. , Phillips Margaret , Boyson Samuel P. , Demeler Borries , Markley John L. , Glass Karen C. 
Published: February 2020

ABSTRACTBromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ (monocytic leukemic zinc-finger protein) HAT (histone acetyltransferase) complex, which is associated with chromosomal translocations known to contribute to the development of acute myeloid leukemia (AML). BRPF1 contains a unique combination of chromatin reader domains including two plant homeodomain (PHD) fingers separated by a zinc knuckle (PZP domain), a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. BRPF1 is known to recruit the MOZ HAT complex to chromatin by recognizing acetylated lysine residues on the N-terminal histone tail region through its bromodomain. However, histone proteins can contain several acetylation modifications on their N-terminus, and it is unknown how additional marks influence bromodomain recruitment to chromatin. Here, we identify the BRPF1 bromodomain as a selective reader of di-acetyllysine modifications on histone H4. We used ITC assays to characterize the binding of di-acetylated histone ligands to the BRPF1 bromodomain and found that the domain binds preferentially to histone peptides H4K5acK8ac and H4K5acK12ac. Analytical ultracentrifugation (AUC) experiments revealed that the monomeric state of the BRPF1 bromodomain coordinates di-acetylated histone ligands. NMR chemical shift perturbation studies, along with binding and mutational analyses, revealed non-canonical regions of the bromodomain-binding pocket that are important for histone tail recognition. Together, our findings provide critical information on how the combinatorial action of post-translational modifications can modulate BRPF1 bromodomain binding and specificity.
“Just be there”
Authors: Karampela Maria , Lacka Ewelina , McLean Graeme 
Published: February 2020

Purpose
In business-to-business (B2B) settings, research on social media sites (SMS) has primarily examined the benefits and challenges relating to their use, as well as factors driving their adoption. Recently, attention has turned to the consequences of using SMS in B2B markets. The purpose of this paper is to extend this line of research by investigating the impact of B2B brands’ social media presence, interactivity and responsiveness on customers’ perceptions of four indicators of brand relationship strength (commitment, intimacy, satisfaction and partner quality).

Design/methodology/approach
Data from an online survey (N = 200) with customers of UK-based B2B firms were analysed using structural equation modelling.

Findings
The study reveals that a supplier’s presence on Twitter, LinkedIn and Facebook has a positive impact on all four brand relationship strength indicators; interactivity enhances perceived partner quality, while responsiveness positively influences commitment. Differences across the three SMS are also observed.

Research limitations/implications
The research was conducted on a sample of UK-based firms with varying degrees of SMS use that may influence the impact on B2B brand relationship strength.

Practical implications
This study indicates that B2B brands ought to focus primarily on presence on SMS, given its positive impact on brand relationship strength. At the same time, however, B2B brands should be active in responding to customers’ queries on SMS, as well as interacting with them to enhance commitment and perceived partner quality, respectively.

Originality/value
This study contributes to the digital marketing and B2B relationships interface and is the first to examine the role of B2B brands’ presence, interactivity and responsiveness on SMS in enhancing relationships with customers.
Group development model and Lean Six Sigma project team outcomes
Authors: Guttenberg Jamie L. 
Published: February 2020

Purpose
The purpose of this study is to examine if there is a difference between service-sector Lean Six Sigma (LSS) project teams that progress through Tuckman’s group development model and those that do not in terms of the number of completed projects, the number of projects completed on time, the length of time to complete the projects and the total cost savings and avoidance because of the projects.

Design/methodology/approach
The research consisted of a quantitative, descriptive methodology. The design included a sample from a service-sector LSS practitioner population, a survey instrument, one independent construct with two levels, four dependent constructs and a multivariate analysis of variance (MANOVA).

Findings
The progression of service-sector LSS teams through Tuckman’s group development model, as measured with the group process questionnaire, significantly influences the teams in terms of the number of completed projects, the number of projects completed on time, the length of time to complete the projects and the total cost savings and avoidance because of the projects.

Research limitations/implications
A limitation of the study is there may be other factors not related to Tuckman’s group development model that can influence the outcomes of LSS projects. These variables may include senior executive buy-in, number of LSS practitioners in the organization, the robustness of LSS training programs, level of talent and other factors not related to Tuckman’s group development model. Another limitation of the study encompassed using a sample of convenience instead of a random sample.

Practical implications
The recommendation for practice is binate. First, service-sector LSS project teams should ensure they progress through the stages of Tuckman’s group development model to enjoy the significantly improved project outcomes. Second, LSS practitioners and trainers should ensure that Tuckman’s group development model is part of the training curriculum.

Social implications
The study demonstrates that all groups should attempt to progress through the stages of Tuckman and Jensen (2010) group development model to enjoy the benefits of working in a cohesive, task-focused team.

Originality/value
This study adds to the body of knowledge because, prior to this study, there was not prior research involving Tuckman’s group development model and LSS team outcomes.
A lean manufacturing road map using fuzzy-DEMATEL with case-based analysis
Authors: Seleem Sameh N. , Attia El-Awady , Karam Ahmed , El-Assal Ahmed 
Published: February 2020

Purpose
This paper aims to develop a lean manufacturing road map for industrial firms by selecting the appropriate lean tools relying on the predefined strategic objectives and the firm constraints. It also illustrates how to prioritize these tools considering their interrelationship.

Design/methodology/approach
Relying on the predefined strategic objectives, operational objectives can be set by using the balanced scorecard (BSC). Afterwards, the theory of constraints (TOC) is introduced to investigate the manufacturing system and to determine its constraints. For these constraints, the principle of fault tree analysis (FTA) is used to determine their root causes. Consequently, lean manufacturing tools/initiatives can be proposed. Finally, the fuzzy-decision making trial and evaluation laboratory (fuzzy-DEMATEL) method is implemented to prioritize these initiatives and to construct a suitable lean road map by managing experts’ knowledge.

Findings
The practical results indicate that diagnosing the manufacturing system and managing experts’ knowledge to select the appropriate lean initiatives, and prioritizing these initiatives relying on the understanding of their interrelationship could support achieving the strategic targets without consuming extra time or resources.

Research limitations/implications
The study is limited to manufacturing firms. Besides, it reinforces the need for investigating the effectiveness of the proposed approach on service sectors.

Practical implications
The study provides a methodology with a real application, to manage experts’ knowledge for developing an effective lean improvement road map. The methodology could be adopted by any manufacturing firm.

Originality/value
The study supports decision makers of a firm to select the improvement initiatives by an original structural approach, which integrates BSC, TOC, FTA and fuzzy-DEMATEL. Besides, the interrelationships among the selected lean initiatives are considered, and results show the importance of analysing these interrelationships during the construction of the lean improvement plan. Moreover, its effectiveness and applicability are validated via a practical case study.
Thermo-mechanical analysis of train wheel-rail contact using a novel finite-element model
Authors: Yang Liuqing , Hu Ming , Zhao Deming , Yang Jing , Zhou Xun 
Published: February 2020

Purpose
The purpose of this paper is to develop a novel method for analyzing wheel-rail (W-R) contact using thermo-mechanical measurements and study the effects of heating on the characteristics of W-R contact under different creepages.

Design/methodology/approach
This study developed an implicit-explicit finite element (FE) model which could solve both partial slip and full sliding problems by setting different angular velocities on the wheels. Based on the model, four material types under six different creepages were simulated.

Findings
The results showed that frictional heating significantly affected the residual stress distribution under large creepage conditions. As creepage increased, the temperature of the wheel tread and rail head rose and the peak value was located at the trailing edge of the contact patch.

Originality/value
The proposed FE model could reduce computational time and thus cost to about one-third of the amount commonly found in previous literature. Compared to other studies, these results are in good agreement and offer a reasonable alternative method for analyzing W-R contact under various conditions.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-07-2019-0298
Innovation within networks – patent strategies for blockchain technology
Authors: Dehghani Milad , Mashatan Atefeh , Kennedy Ryan William 
Published: February 2020

Purpose
Understanding a technology’s patent landscape, including patent strategies, helps organizations position themselves regarding their innovation and provides insight about a technology’s future direction. This study aims to provide an overview of the blockchain technology patenting trends and outlines an exploratory framework of patenting strategies for blockchain.

Design/methodology/approach
A total of 3,234 registered patents are analyzed to determine the geographical distribution and identify key actors patenting around the globe. In addition, an empirical study consisting of multiple case studies in the form of ten in-depth interviews with owners/managers of organizations based in North America was conducted to understand organizations’ strategies for patenting the blockchain technology.

Findings
Several novel insights regarding the strategies are used for blockchain technology patenting. For example, the existence of strong anti-patent sentiment which results in a lack of patenting by start-up organizations or has led to a form of open source patenting strategy. Larger organizations appear to be patenting defensively, and small to medium organizations are primarily patenting to defend their competitive advantage.

Practical implications
Start-up organizations harboring anti-patent sentiment should consider the open-source patenting strategy to ensure that the collaborative innovation network can continue. They should also consider collaborating with other actors within the network to have a competitive position in the market.

Originality/value
To the authors’ knowledge, this paper is the first to conduct an empirical study with organizations currently using the blockchain technology to understand patenting strategies used for blockchain.
Biocybernetic model for the diagnosis and treatment of chronic pain
Authors: Hormazabal Fernando , Lavanderos Leonardo , Malpartida Alejandro 
Published: February 2020

PurposeThe biopsychosocial model (BPSM) on chronic pain is an interactive psychophysiological behavior pattern that cannot be separated into different independent components. However, the epistemological analysis of the classic BPSM, based on “biopsychosocial factors,” can be reduced to a list of biological, psychological and social factors, which can be addressed simultaneously, but independently, where simultaneity is seen as relationality. The purpose of this paper is to achieve a systemic and transdisciplinary vision of the idea of simultaneity and multidisciplinarity of the BPSM and propose a new model for the diagnosis and treatment of chronic pain.Design/methodology/approachBased on the following conceptual triad, co-autonomy, centralization and non-requisite variety, to constitute systemic indicators, the authors design a new conceptual model of cohesion, communication, conduction and coordination (CO4) model to deal with the relational system of chronic pain patients.FindingsThe indicators of the CO4 system as transdisciplinary structure create and focus a completely new relationship regarding the relational system of the chronic pain patients. This new conceptual framework transcends the objects and frameworks of each discipline separately, going beyond the multidisciplinary model.Originality/valueThe CO4 model allows a diagnostic and therapeutic standardization as a new model on chronic pain, improving therapeutic efficiency, resource use and laying the foundation for a common language in future chronic pain research.
Courageous leadership: delivering results in turbulent times
Authors: Phillips Jack J. , Phillips Patti P. 
Published: February 2020

Purpose
In uncertain times, courageous leaders must be in place, stepping forward to take action to drive results. Because there is really no such thing as a natural-born leader, the organization must constantly develop current and new leaders. Leadership skills and leader behavior are shaped and molded over time, but also can be dramatically changed and improved with a variety of effective leadership development programs. The perplexing issue about leaders and leadership development is the negative press it often receives. The root cause of this problem is not necessarily the content of leadership development programs or even the way that they are delivered, it is the definition of leadership success and the success of leadership development.

Design/methodology/approach
The purpose of this paper is to illustrate the success of a courageous leader does not occur until impact is achieved in the organization.

Findings
The courageous leader is one who can deliver on all levels of outcomes in the face of many difficulties, challenges and uncertainties in ambiguous environments.

Originality/value
Great leaders deliver great results, including the impact they have on their organizations or spheres of influence. Without impact, leaders are ineffective. To achieve success in these turbulent times requires leaders to be effective in delivering on five levels of outcomes, including impact and ROI. The courageous leader is one who can deliver on all levels of outcomes in the face of many difficulties, challenges and uncertainties in ambiguous environments.
Converting strategic ambiguity to competitive advantage: How Philips Lighting solved the challenge of LED technology disruption
Authors: Schoemaker Paul J.H. , Day George S. , Rao Govi 
Published: February 2020

Purpose
The case of Philips Lighting shows how management coped with the ambiguous but real threats and opportunities of a highly disruptive emerging technology using three insight-producing approaches: 10; 10;∙9; Probe and learn widely. 10;∙9; Explore creative hypotheses. 10;∙9; Develop multiple scenarios. 10;

Design/methodology/approach
The case shows how leadership teams can effectively respond when confronted with ambiguous but potentially disruptive signals.

Findings
When assessing a potential digital disruption, leaders can begin by probing the latent needs of current as well as potential customers more thoroughly. Once ‘probe and learn’ approaches have surfaced new perspectives and strategic possibilities, the organization should generate context-expanding hypotheses about the meaning and consequences of various weak signals.

Practical implications
A limited number of disparate scenarios, clearly organized around a few pivotal uncertainties, provide leaders with a strategic context for interpreting ambiguous signals.

Originality/value
In the current VUCA environmen, when turbulence is high or major disruption is feared, all leaders need to examine at least one scenario that directly challenges the organization’s current mindset.
Underworked and overpaid
Authors: Lilly Juliana 
Published: February 2020

Theoretical basis
The purpose of this paper is to help readers better understand the psychological impact of employees feeling underutilized in the workplace.

Research methodology
The case is based on primary data collected from Jonathan and describes his actual experience in the workplace. Mark also provided input on the situation. Because Jonathan and Mark are still employed in the same institution, the names have been disguised to protect their identity.

Case overview/synopsis
Jonathan is a highly motivated and successful employee who was promoted into a position that had no real responsibility. His manager would not restructure the job to make it more challenging or rewarding, so after three years of frustration, Jonathan has to decide if he should keep trying to fix the job, coast until retirement or resign.

Complexity academic level
This case is applicable for undergraduate business courses in organizational behavior, principles of management, principles of human resource management or leadership.
Reasons for and outcome of occupational therapy consultation and treatment in the context of multidisciplinary cancer rehabilitation; a historical cohort study
Authors: Rijpkema Corine , Duijts Saskia F. A. , Stuiver Martijn M. 
Published: February 2020

AbstractIntroductionThe aim of this study was to investigate reasons why people consulted an occupational therapist following cancer treatment, and to examine the outcome of occupational therapy interventions, in the context of multidisciplinary rehabilitation.MethodsData from 181 patients were collected retrospectively. The International Classification of Human Functioning and Health (ICF) was used to describe the reasons for occupational therapy consultation. Patients had completed the Canadian Occupational Performance Measurement (COPM) before and after the occupational therapy intervention. Change scores were calculated with a 95% confidence interval and a two‐sided p‐value obtained from a paired t‐test.ResultsThe reasons for occupational therapy consultation were predominantly within the ICF domain “Activities and Participation”. On average, patients improved 3.0 points (95% CI 2.8–3.2) on the performance scale of the COPM, and 3.4 points (95% CI 3.2–3.7) on the satisfaction scale (both: p = <.001).ConclusionThe result of this study supports the added value of occupational therapy to cancer rehabilitation, and emphasise the positive effect of occupational therapy on everyday functioning. Controlled clinical studies are needed to strengthen the evidence.
Associations between Medicaid expansion and nurse staffing ratios and hospital readmissions
Authors: Tarazi Wafa W. 
Published: February 2020

AbstractObjectiveTo examine the associations between Medicaid expansion and nurse staffing ratios and hospital‐wide readmission rates.Data sourcesSecondary data from the 2011‐2016 Healthcare Cost Report Information System, the American Hospital Association Annual Survey, and the Hospital Compare data.Study designDifference‐in‐difference models are used to compare outcomes in hospitals located in states that expanded Medicaid with those located in nonexpansion states. The changes in nurse staffing ratios and hospital‐wide readmission rates are calculated in each one of the postexpansion years (2014, 2015, and 2016), compared to pre‐expansion.Principal findingsResults indicate that nurse staffing ratios increased, whereas hospital‐wide readmission rates declined in expansion states relative to nonexpansion states. Nurse staffing ratios increased by 0.33, 0.42, and 0.46 registered nurses hours per adjusted patient days in 2014, 2015, and 2016 in hospitals located in expansion states, compared with hospitals in nonexpansion states after expansion. This increase was statistically significant (P < .001) in 2015 and 2016, but marginally significant (P = .016) in 2014. Hospital‐wide readmission rates statistically significantly decreased by 9, 16, and 18 per 10 000 patients (P < .001) in 2014, 2015, and 2016, respectively, in expansion vs nonexpansion states hospitals after expansion.ConclusionsMedicaid expansion was associated with gradually improved hospitals' nurse staffing ratios and hospital‐wide readmission rates from 2014 through 2016. The continued monitoring of quality measures of hospitals can help assess the impact of Medicaid expansion over a longer period of time.