bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective observational analysis of esophageal foreign bodies: a novel characterization based on shape
Authors: Ruan Wei-Shuyi , Li Yu-Ning , Feng Meng-Xiao , Lu Yuan-Qiang 
Published: March 2020

AbstractThis single-center retrospective study aims to investigate the clinical features of esophageal foreign bodies (EFBs) and determine the influence of EFB shapes on management and prognosis. A total of 427 patients aged 13 to 95 years with suspected EFB ingestion were enrolled between January 2013 and June 2018, 183 of whom were male. EFBs were divided into six shapes: pin (n = 161), sheet (n = 97), trident (n = 51), spindle (n = 66), irregular (n = 46), and sphere (n = 6). Spindle-shaped EFBs correlated with a significantly higher rate of perforation and severe complications (P < 0.001 and P = 0.021, respectively) than any other EFB shape, while sheet-shaped EFBs were linked to less severe complications (P = 0.006). The number of pressure points was provided to stratify the risk of poor prognosis for each shape. EFBs with only two pressure points (pin and spindle EFBs) required more advanced management strategies and were correlated with a higher number of patients suffering esophageal perforation (27.11%) and severe complications (12.44%) when compared with other shapes (χ2 = 11.149 and P = 0.001; χ2 = 5.901 and P = 0.015, respectively). Spindle shape was an independent risk factor for poor prognosis, and contributed a more clinical risk than the pin shape. In conclusion, clinical features, management, perforation rate, and severe complications differed based on EFB shape. The EFBs with two pressure points, especially the spindle-shaped EFBs, were more dangerous compared with those with more pressure points.
Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding
Authors: Huang Bill X. , Hu Xin , Kwon Heung-Sun , Fu Cheng , Lee Ji-Won , Southall Noel , Marugan Juan , Kim Hee-Yong 
Published: March 2020

AbstractAdhesion G protein-coupled receptors (aGPCR) are characterized by a large extracellular region containing a conserved GPCR-autoproteolysis-inducing (GAIN) domain. Despite their relevance to several disease conditions, we do not understand the molecular mechanism by which aGPCRs are physiologically activated. GPR110 (ADGRF1) was recently deorphanized as the functional receptor of N-docosahexaenoylethanolamine (synaptamide), a potent synaptogenic metabolite of docosahexaenoic acid. Thus far, synaptamide is the first and only small-molecule endogenous ligand of an aGPCR. Here, we demonstrate the molecular basis of synaptamide-induced activation of GPR110 in living cells. Using in-cell chemical cross-linking/mass spectrometry, computational modeling and mutagenesis-assisted functional assays, we discover that synaptamide specifically binds to the interface of GPR110 GAIN subdomains through interactions with residues Q511, N512 and Y513, causing an intracellular conformational change near TM6 that triggers downstream signaling. This ligand-induced GAIN-targeted activation mechanism provides a framework for understanding the physiological function of aGPCRs and therapeutic targeting in the GAIN domain.
Solar-cycle irradiance variations over the last four billion years
Authors: Shapiro Anna V. , Shapiro Alexander I. , Gizon Laurent , Krivova Natalie A. , Solanki Sami K. 
Published: March 2020

Context. The variability of the spectral solar irradiance (SSI) over the course of the 11-year solar cycle is one of the manifestations of solar magnetic activity. There is strong evidence that the SSI variability has an effect on the Earth’s atmosphere. The faster rotation of the Sun in the past lead to a more vigorous action of solar dynamo and thus potentially to larger amplitude of the SSI variability on the timescale of the solar activity cycle. This could lead to a stronger response of the Earth’s atmosphere as well as other solar system planets’ atmospheres to the solar activity cycle.
Aims. We calculate the amplitude of the SSI and total solar irradiance (TSI) variability over the course of the solar activity cycle as a function of solar age.
Methods. We employed the relationship between the stellar magnetic activity and the age based on observations of solar twins. Using this relation, we reconstructed solar magnetic activity and the corresponding solar disk area coverages by magnetic features (i.e., spots and faculae) over the last four billion years. These disk coverages were then used to calculate the amplitude of the solar-cycle SSI variability as a function of wavelength and solar age.
Results. Our calculations show that the young Sun was significantly more variable than the present Sun. The amplitude of the solar-cycle TSI variability of the 600 Myr old Sun was about ten times larger than that of the present Sun. Furthermore, the variability of the young Sun was spot-dominated (the Sun being brighter at the activity minimum than in the maximum), that is, the Sun was overall brighter at activity minima than at maxima. The amplitude of the TSI variability decreased with solar age until it reached a minimum value at 2.8 Gyr. After this point, the TSI variability is faculae-dominated (the Sun is brighter at the activity maximum) and its amplitude increases with age.
A Γ-convergence result for fluid-filled fracture propagation
Authors: Bach Annika , Sommer Liesel 
Published: March 2020

In this paper we provide a rigorous asymptotic analysis of a phase-field model used to simulate pressure-driven fracture propagation in poro-elastic media. More precisely, assuming a given pressurep ∈ W1,∞ (Ω) we show that functionals of the form$$ E(\vec{u})={\int }_{\mathrm{\Omega }} e(\vec{u}):\mathbb{C}e(\vec{u})+p\nabla \cdot \vec{u}+\left\langle \nabla p,\vec{u}\right\rangle\enspace \mathrm{d}x+{\mathcal{H}}^{n-1}({J}_{\vec{u}}),\enspace \vec{u}\in \mathrm{G}{SBD}(\mathrm{\Omega })\cap {L}^1(\mathrm{\Omega };{\mathbb{R}}^n) $$can be approximated in terms of Γ-convergence by a sequence of phase-field functionals, which are suitable for numerical simulations. The Γ-convergence result is complemented by a numerical example where the phase-field model is implemented using a Discontinuous Galerkin Discretization.
Immunsuppression bei schubförmig-remittierender Multipler Sklerose
Authors: Meuth Sven G. 
Published: March 2020

ZUSAMMENFASSUNGDie frühzeitige, individualisierte Therapie der schubförmig-remittierenden Multiplen Sklerose (RRMS) kann die Prognose der Patienten verändern. Wird eine Eskalationstherapie notwendig, steht heute eine ganze Reihe von Therapeutika zur Auswahl. Dabei stellt sich die Frage nach der individuell besten Strategie.
Sleep Quality in Children and Adults with Rett Syndrome
Authors: Leven Y. , Wiegand F. , Wilken B. 
Published: March 2020

Abstract
Background Over 80% of individuals suffering from Rett syndrome (RTT) are affected over their life period by sleeping disorders. Little is known about the impact of those on the quality of life and a clinical approach to the treatment of sleep disturbances is lacking.
Aims Primary aim was to assess sleep quality in children and adults. Secondary aim was to assess behavioral disorders and their relationship to sleep quality. The medication taken by the subjects was also included.
Methods Sleep quality and medication were assessed using the sleeping questionnaire for children with neurological and other complex diseases (SNAKE). Behavioral disorders were assessed by the Rett Syndrome Behavior Questionnaire (RSBQ). Questionnaires were sent to the 700 members of the Elternhilfe für Kinder mit Rett Syndrom in Deutschland e.V. (Rett Aid) of which 287 were included. Questionnaires were filled out by the primary caregivers.
Results Sleep quality was rated as very good to good by over 60% of caregivers in contrast to data available in the literature. Behavioral disorders related to regression such as loss of acquired hand skills (p = 0.046) and isolation (p = 0.002) were found to be associated with sleep quality. Melatonin showed a significant association (p = 0.007) with sleep quality.
Conclusion Our study showed sleep dysfunction to be less prevalent in RTT-affected individuals than evidence from past studies has suggested. Nevertheless, this remains a subjective assessment of sleep quality and therefore the need to find objective, disorder-specific parameters that measure sleep quality in RTT patients persists.
Gestational Age at Birth and Risk of Developmental Delay: The Upstate KIDS Study
Authors: Hochstedler Kimberly A. , Bell Griffith , Park Hyojun , Ghassabian Akhgar , Bell Erin M. , Sundaram Rajeshwari , Grantz Katherine L. , Yeung Edwina H. 
Published: March 2020

Abstract
Objective The aim of this study is to model the association between gestational age at birth and early child development through 3 years of age.
Study Design Development of 5,868 children in Upstate KIDS (New York State; 2008–2014) was assessed at 7 time points using the Ages and Stages Questionnaire (ASQ). The ASQ was implemented using gestational age corrected dates of birth at 4, 8, 12, 18, 24, 30, and 36 months. Whether children were eligible for developmental services from the Early Intervention Program was determined through linkage. Gestational age was based on vital records. Statistical models adjusted for covariates including sociodemographic factors, maternal smoking, and plurality.
Results Compared with gestational age of 39 weeks, adjusted odds ratios (aOR) and 95% confidence intervals of failing the ASQ for children delivered at <32, 32–34, 35–36, 37, 38, and 40 weeks of gestational age were 5.32 (3.42–8.28), 2.43 (1.60–3.69), 1.38 (1.00–1.90), 1.37 (0.98–1.90), 1.29 (0.99–1.67), 0.73 (0.55–0.96), and 0.51 (0.32–0.82). Similar risks of being eligible for Early Intervention Program services were observed (aOR: 4.19, 2.10, 1.29, 1.20, 1.01, 1.00 [ref], 0.92, and 0.78 respectively for <32, 32–34, 37, 38, 39 [ref], 40, and 41 weeks).
Conclusion Gestational age was inversely associated with developmental delays for all gestational ages. Evidence from our study is potentially informative for low-risk deliveries at 39 weeks, but it is notable that deliveries at 40 weeks exhibited further lower risk.
Agency and Trauma in the Palestinian Struggle to Remain
Authors: Nassar Maha 
Published: March 2020

Abstract
Adel Manna’s Nakba and Survival: The Story of the Palestinians Who Remained in Haifa and the Galilee, 1948–1956 appeared in Arabic and Hebrew in 2016–2017. Manna’s book gives voice to the experience of the first generation of Palestinians living within the State of Israel. Here, four scholars of Palestinian and Israeli history review Nakba and Survival and weigh its importance for reckoning with the entangled history of the creation of Israel and the related dispossession of Palestinians during and after 1948.
Incidence of Prehypertension and Hypertension in Rural India, 2012–2018: A Sex-Stratified Population-Based Prospective Cohort Study
Authors: Rai Rajesh Kumar , Kumar Chandan , Singh Prashant Kumar , Singh Lucky , Barik Anamitra , Chowdhury Abhijit 
Published: March 2020

AbstractBACKGROUNDIndia is home to the largest number of hypertensive individuals, and factors responsible for the incidence of hypertension are poorly understood. This study examines predictors of transition to different stages of hypertension—incidence of hypertension, incidence of prehypertension, and incidence of prehypertension to hypertension.METHODSPopulation-based survey data from the Birbhum Population Project, located in West Bengal, India were used. A cohort of 8,977 individuals (male: 3,934, female: 5,043), participated in the 2012–13 survey, and were followed up for resurvey in 2017–18. The Seventh Report of the Joint National Committee (JNC 7) guidelines were followed to define hypertension. Bivariate and multivariate Poisson regression analyses were conducted to attain the study objective.RESULTSThe incidence of hypertension, prehypertension among males (7.9% and 45.3%, respectively) is higher than that among females (5.9% and 32.7%, respectively). However, the incidence of prehypertension to hypertension is lower among males (23.6%) than among females (33.6%). Among both sexes, with age, the incidence of hypertension, and incidence of prehypertension to hypertension appeared to increase, whereas incidence of prehypertension among females increased with age. Findings indicate a diverse gradient of socioeconomic, behavioral, and anthropometric characteristics influencing the incidence of different stages of hypertension.CONCLUSIONSWith a focus on females and the richest individuals, this study proposes that an appropriate intervention be designed in keeping with the socioeconomic, behavioral gradient of incidence of different stages of hypertension. The role of anthropometric indicators in hypertension is proposed to be further studied for better population-based screening.
Unique and highly specific cyanogenic glycoside localization in stigmatic cells and pollen in the genus Lomatia (Proteaceae)
Authors: Ritmejerytė Edita , Boughton Berin A , Bayly Michael J , Miller Rebecca E 
Published: March 2020

Abstract

Background and Aims
Floral chemical defence strategies remain understudied despite the significance of flowers to plant fitness, and the fact that many flowers contain secondary metabolites that confer resistance to herbivores. Optimal defence and apparency theories predict that the most apparent plant parts and/or those most important to fitness should be most defended. To test whether within-flower distributions of chemical defence are consistent with these theories we used cyanogenic glycosides (CNglycs), which are constitutive defence metabolites that deter herbivores by releasing hydrogen cyanide upon hydrolysis.

Methods
We used cyanogenic florets of the genus Lomatia to investigate at what scale there may be strategic allocation of CNglycs in flowers, what their localization reveals about function, and whether levels of floral CNglycs differ between eight congeneric species across a climatic gradient. Within-flower distributions of CNglycs during development were quantified, CNglycs were identified and their localization was visualized in cryosectioned florets using matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI).

Key Results
Florets of all congeneric species studied were cyanogenic, and concentrations differed between species. Within florets there was substantial variation in CNglyc concentrations, with extremely high concentrations (up to 14.6 mg CN g−1 d. wt) in pollen and loose, specialized surface cells on the pollen presenter, among the highest concentrations reported in plant tissues. Two tyrosine-derived CNglycs, the monoglycoside dhurrin and diglycoside proteacin, were identified. MALDI-MSI revealed their varying ratios in different floral tissues; proteacin was primarily localized to anthers and ovules, and dhurrin to specialized cells on the pollen presenter. The mix of transient specialized cells and pollen of L. fraxinifolia was ~11 % dhurrin and ~1.1 % proteacin by mass.

Conclusions
Tissue-specific distributions of two CNglycs and substantial variation in their concentrations within florets suggests their allocation is under strong selection. Localized, high CNglyc concentrations in transient cells challenge the predictions of defence theories, and highlight the importance of fine-scale metabolite visualization, and the need for further investigation into the ecological and metabolic roles of CNglycs in floral tissues.
How Religious Jewish and Muslim Students of Social Work Cope in a Secular College
Authors: Ranz Rebecca , Allassad Alhuzail Nuzha 
Published: March 2020

Abstract
The social work profession’s worldview, which is expressed through education and practice, is ‘almost exclusively secular in colour and context’. This qualitative study in the phenomenological tradition of ten religious Jewish and ten religious Arab-Muslim students of social work in Israel found that both groups coped similarly with the secularity, despite their ethnic, national and religious differences. Most of them adopted emotion-focussed coping strategies that isolated them from their academic surroundings. The religious students who adopted a problem-focussed strategy opened themselves to new knowledge. Knowing about these strategies may help faculty and other personnel in social work schools not only to be better acquainted with this minority but also to provide an environment that is receptive to and respectful of the religious student.
Read-through transcripts in lung: germline genetic regulation and correlation with the expression of other genes
Authors: Maspero Davide , Dassano Alice , Pintarelli Giulia , Noci Sara , De Cecco Loris , Incarbone Matteo , Tosi Davide , Santambrogio Luigi , Dragani Tommaso A , Colombo Francesca 
Published: March 2020

AbstractTranscripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here, we investigated whether the expression of read-through transcripts previously identified in the non-involved lung tissue of lung adenocarcinoma patients was genetically regulated. Data on genome-wide single nucleotide variant genotypes and expression levels of 10 read-through transcripts in 201 samples of lung tissue were combined to identify expression quantitative trait loci (eQTLs). Then, to identify genes whose expression levels correlated with the 10 read-through transcripts, we used whole transcriptome profiles available for 154 patients. For 8 read-though transcripts, we identified 60 eQTLs (false discovery rate &lt;0.05), including 17 cis-eQTLs and 43 trans-eQTLs. These eQTLs did not maintain their behavior on the ‘parental’ genes involved in the read-through transcriptional event. The expression levels of 7 read-through transcripts were found to correlate with the expression of other genes: CHIA–PIFO and CTSC–RAB38 correlated with CHIA and RAB38, respectively, while 5 other read-through transcripts correlated with 43 unique non-parental transcripts; thus offering indications about the molecular processes in which these chimeric transcripts may be involved. We confirmed 9 eQTLs (for 4 transcripts) in the non-involved lung tissue from an independent series of 188 lung adenocarcinoma patients. Therefore, this study indicates that the expression of four read-through transcripts in normal lung tissue is under germline genetic regulation, and that this regulation is independent of that of the genes involved in the read-through event.
Optimization and Validation of HPTLC Method for Estimation of Ulipristal Acetate in Presence of Its Forced Degradation Products
Authors: Kamdar Gulzar , Desai Sonal 
Published: March 2020

Abstract
Ulipristal acetate (UPA) is used as emergency contraceptive and for uterine fibroids. No validated method has been reported to estimate UPA in presence of its degradation products. Therefore it is mandatory to develop method which can accurately measure it in presence of impurity. A simple and sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the estimation of UPA. Pre-coated silica gel 60F254 TLC plates were as stationary phase and ethyl acetate:toluene:glacial acetic acid (4:7:0.3, v/v/v) was used as mobile phase. Drug was subjected to acid and alkali hydrolysis, oxidation, photo degradation and thermal degradation to study its degradation behavior. UPA eluted with Rf value 0.38 ± 0.02. The method was found to be linear in the concentration range of 400–3,600 ng/band. Limit of detection and limit of quantitation were found to be 72.7786 ng/band and 220.5412 ng/band, respectively. The % recovery of the proposed method was found to be 100.05–100.65%. The proposed method was specific to measure UPA in presence of degradants. The method was found to be accurate, precise, robust and can be useful for routine analysis of formulations containing UPA in presence of its degradation products.
Derivation and Validation of a Novel Severity Scoring System for Pneumonia at Intensive Care Unit Admission
Authors: Carmo Thomas A , Ferreira Isabella B , Menezes Rodrigo C , Telles Gabriel P , Otero Matheus L , Arriaga Maria B , Fukutani Kiyoshi F , Neto Licurgo P , Agareno Sydney , Filgueiras Filho Nivaldo M , Andrade Bruno B , Akrami Kevan M 
Published: March 2020

Abstract

Background
Severity stratification scores developed in intensive care units (ICUs) are used in interventional studies to identify the most critically ill. Studies that evaluate accuracy of these scores in ICU patients admitted with pneumonia are lacking. This study aims to determine performance of severity scores as predictors of mortality in critically ill patients admitted with pneumonia.

Methods
Prospective cohort study in a general ICU in Brazil. ICU severity scores (Simplified Acute Physiology Score 3 [SAPS 3] and Sepsis-Related Organ Failure Assessment [qSOFA]), prognostic scores of pneumonia (CURB-65 [confusion, urea, respiratory rate, blood pressure, age] and CRB-65 [confusion, respiratory rate, blood pressure, age]), and clinical and epidemiological variables in the first 6 hours of hospitalization were analyzed.

Results
Two hundred patients were included between 2015 and 2018, with a median age of 81 years (interquartile range, 67–90 years) and female predominance (52%), primarily admitted from the emergency department (65%) with community-acquired pneumonia (CAP, 80.5%). SAPS 3, CURB-65, CRB-65,and qSOFA all exhibited poor performance in predicting mortality. Multivariate regression identified variables independently associated with mortality that were used to develop a novel pneumonia-specific ICU severity score (Pneumonia Shock score) that outperformed SAPS 3, CURB-65, and CRB-65. The Shock score was validated in an external multicenter cohort of critically ill patients admitted with CAP.

Conclusions
We created a parsimonious score that accurately identifies patients with pneumonia at highest risk of ICU death. These findings are critical to accurately stratify patients with severe pneumonia in therapeutic trials that aim to reduce mortality.
Modeling Infectious Diseases in Healthcare Network (MInD-Healthcare) Framework for Describing and Reporting Multidrug-resistant Organism and Healthcare-Associated Infections Agent-based Modeling Methods
Authors: Slayton Rachel B , O’Hagan Justin J , Barnes Sean , Rhea Sarah , Hilscher Rainer , Rubin Michael , Lofgren Eric , Singh Brajendra , Segre Alberto , Paul Prabasaj 
Published: March 2020

Abstract
Mathematical modeling of healthcare-associated infections and multidrug-resistant organisms improves our understanding of pathogen transmission dynamics and provides a framework for evaluating prevention strategies. One way of improving the communication among modelers is by providing a standardized way of describing and reporting models, thereby instilling confidence in the reproducibility and generalizability of such models. We updated the Overview, Design concepts, and Details protocol developed by Grimm et al [11] for describing agent-based models (ABMs) to better align with elements commonly included in healthcare-related ABMs. The Modeling Infectious Diseases in Healthcare Network (MInD-Healthcare) framework includes the following 9 key elements: (1) Purpose and scope; (2) Entities, state variables, and scales; (3) Initialization; (4) Process overview and scheduling; (5) Input data; (6) Agent interactions and organism transmission; (7) Stochasticity; (8) Submodels; and (9) Model verification, calibration, and validation. Our objective is that this framework will improve the quality of evidence generated utilizing these models.