bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of histone H3K4me3 modifications between early embryos and somatic tissues in cattle
Authors: Ishibashi Mao , Ikeda Shuntaro , Minami Naojiro 
Published: November 2020

AbstractEpigenetic changes induced in the early developmental stages by the surrounding environment can have not only short-term but also long-term consequences throughout life. This concept constitutes the “Developmental Origins of Health and Disease” (DOHaD) hypothesis and encompasses the possibility of controlling livestock health and diseases by epigenetic regulation during early development. As a preliminary step for examining changes of epigenetic modifications in early embryos and their long-lasting effects in fully differentiated somatic tissues, we aimed to obtain high-throughput genome-wide histone H3 lysine 4 trimethylation (H3K4me3) profiles of bovine early embryos and to compare these data with those from adult somatic tissues in order to extract common and typical features between these tissues in terms of H3K4me3 modifications. Bovine blastocysts were producedin vitroand subjected to chromatin immunoprecipitation-sequencing analysis of H3K4me3. Comparative analysis of the blastocyst-derived H3K4me3 profile with publicly available data from adult liver and muscle tissues revealed that the blastocyst profile could be used as a “sieve” to extract somatic tissue-specific modifications in genes closely related to tissue-specific functions. Furthermore, principal component analysis of the level of common modifications between blastocysts and somatic tissues in meat production-related and imprinted genes well characterized inter- and intra-tissue differences. The results of this study produced a referential genome-wide H3K4me3 profile of bovine early embryos and revealed its common and typical features in relation to the profiles of adult tissues.Supplementary informationSupplementary data are submitted along with the main manuscript. The ChIP-seq datasets for bovine blastocysts have been deposited in the Gene Expression Omnibus of NCBI with accession number GSE161221.
A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Authors: Celik Hamza , Krug Ethan , Zhang Christine RC , Han Wentao , Issa Nancy , Koh Won Kyun , Bjeije Hassan , Kukhar Ostap , Allen Maggie , Li Tindao , Fisher Daniel AC , Fowles Jared , Wong Terrence N. , Stubbs Matthew C. , Koblish Holly K. , Oh Stephen T. , Challen Grant A. 
Published: November 2020

ABSTRACTMyeloproliferative neoplasms (MPNs) are chronic blood diseases with significant morbidity and mortality. While sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant proportion of patients progressing to rapidly fatal secondary acute myeloid leukemia (sAML). Therapeutic discovery has been hampered by the inability of genetically-engineered mouse models to generate key human pathologies such as bone marrow fibrosis. To circumvent these limitations, here we present a humanized animal model of myelofibrosis (MF) patient-derived xenografts (PDXs). These PDXs robustly engrafted patient cells which recapitulated the patient’s genetic hierarchy and pathologies such as reticulin fibrosis and propagation of MPN-initiating stem cells. The model can select for engraftment of rare leukemic subclones to identify MF patients at-risk for sAML transformation, and can be used as a platform for genetic target validation and therapeutic discovery. We present a novel but generalizable model to study human MPN biology.STATEMENT OF SIGNIFICANCEAlthough the genetic events driving myeloproliferative neoplasms (MPNs) are well-defined, therapeutic discovery has been hampered by the inability of murine models to replicate key patient pathologies. Here, we present a patient-derived xenograft (PDX) system to model human myelofibrosis that reproduces human pathologies and is amenable to genetic and pharmacological manipulation.
Cladosporium herbarumpeptidogalactomannan triggers significant defense responses in whole tobacco plants
Authors: de B. Montebianco Caroline , Mattos Bianca B. , da F Silva Tatiane , Barreto-Bergter Eliana , Vaslin Maite F S 
Published: November 2020

AbstractCladosporium herbarumis one of the most frequently occurring fungal species, with a worldwide distribution, and is found in almost all man-occupied niches in organic and inorganic matter and as a phytopathogen on certain agricultural crops. The structure of the most abundant glycoprotein from theC. herbarumcell wall, peptidogalactomanann or pGM, was previously elucidated and includes carbohydrates (76%), with mannose, galactose and glucose as its main monosaccharides (52:36:12 molar ratio). pGM was able to strongly induce the expression of defense-related genes and ROS accumulation when in contact with BY2 tobacco cells. Here, using two distinctNicotiana tabacumcultivars, Xanthi and SR1, we evaluated the ability ofC. herbarumpGM to induce SAR-like defense by studying its antiviral activity againstTobacco mosaic virus(TMV) and the induction of SAR markers includingPRgenes and ROS accumulation. Our results show that pGM induced a strong activation of defense responses in treated plants from both tobacco cultivars, contributing to the impairment of viral infection. Expression levels of the pathogenesis-related genesPR-1a(unknown function),PR-2(□-1-3endoglucanase)PR-3(chitinase), andPR-5(thaumatin-like protein), the phenylpropanoid pathway genePAL(phenylalanine ammonia-lyase) and genes involved in plant stress responses and innate immunity, such asLOX1(lipoxygenase) andNtPrxN1(peroxidase), were strongly induced until 120 h after pGM spray application. Accumulation of superoxide radicals was also observed in a pGM dose-dependent manner.
Innovativeness and performance: the joint effect of relational trust and combinative capability
Authors: Parra-Requena Gloria , Ruiz-Ortega María José , Garcia-Villaverde Pedro M. , Ramírez F. Javier 
Published: November 2020

PurposeThis work aims to develop a configurational model to explain how relational trust and combinative capability can jointly improve the relationship between innovativeness and firm's performance.Design/methodology/approachThe empirical study was developed on a sample of 224 companies in the footwear industry in Spain. Hierarchical regression analysis was used to test the hypotheses in order to confirm the proposed configurational model.FindingsThe partial results demonstrate the significant effect of relational trust on the innovativeness-performance relationship but, unexpectedly, reveals the non-significant effect of combinative capability on this relationship. The triple interaction effects model provides new insights into the positive effect of combinative capability on the innovativeness-performance relationship once firms gain relational trust from their contacts.Research limitations/implicationsThe cross-sectional nature of the study imposes a limitation on the results. Nevertheless, due to the detailed information required to achieve the aims of the research, a longitudinal study could be excessively complex. In any event, the cross-sectional approach of the study accomplishes the proposed aim.Practical implicationsManagers should involve the employees of the firm in order to improve the effectiveness of continuous innovation, encouraging them to establish trusting relationships with external agents and contributing to combine the relevant external knowledge with the individual and collective knowledge available in the firm.Originality/valueThis work contributes to the existing literature with a more complete picture of the influence of innovativeness on firms' performance, highlighting that performance is affected by the coherence of the configuration of innovativeness, relational trust and combination capability.
Hierarchical value-attainment paths of CBEC consumers: a means-end-chain perspective
Authors: Xu Xiao-Yu , Tayyab Syed Muhammad Usman , Chang Fang-Kai , Zhao Kai 
Published: November 2020

PurposeThis study elicits the critical attributes, consequences and values associated with the purchasing process in the context of cross-border e-commerce (CBEC). The purpose is to provide a better understanding of the fundamental factors that determine consumer values in CBEC.Design/methodology/approachThe study applies the means-end-chain theory and soft-laddering techniques to interview 60 CBEC consumers to construct an implication matrix and a hierarchical value map (HVM) of the consumer purchasing process, consisting of attribute-consequence-value (A-C-V) paths.FindingsBy analyzing the significant linkages, elements, ladders and chains in the HVM, four dominant A-C-V paths were identified: economic-driven, efficiency-driven, progress-driven and quality-driven paths.Research limitations/implicationsThis study included only Chinese CBEC buyers. This limitation might affect the generalizability of the conclusions as culture, purchase habits and economic development differ between China and other countries.Practical implicationsThe results of this study provide CBEC practitioners an understanding of the consumer purchasing process and how consumer values are associated with platform characteristics. Thus, the results aid practitioners in allocating resources and developing CBEC platforms in an appropriate manner and direction.Originality/valueThis study sheds lights on the emerging phenomenon of CBEC. By applying the means-end-chain approach, the study provides a comprehensive HVM for interpreting the consumer online purchasing process in this novel context. By illustrating the dominant paths, this research provides deeper theoretical insights into the specific focuses of CBEC consumer purchasing.
Accounting for the unaccountable – coping with COVID
Authors: Salterio Steven E. 
Published: November 2020

Purpose
The purpose of this paper is to understand what are the best projections of these events effects on organizations and economies. The onset of the COVID-19 pandemic leads to a combination of economic and public health circumstances that challenge the accounting for and accountability of organizations that are mostly outside of their experience and that of academics for the past 50 years.

Design/methodology/approach
Through evidence-based policymaking research, evaluation and reporting tools the author draws on the extant research literature to develop estimates of likely effects of these events on organizations and economies.

Findings
The process of investigating this subject led the author to write a short research synthesis paper (Salterio 2020a) that summarized the historical economic evidence about the Spanish flu of 1918–1920 and various simulations of potential pandemic macroeconomic effects. This evidence allowed the author to quantify the potential effects of the crisis less than a month into the North American economic shutdown.

Originality/value
Using that research synthesis the author responded to the call for papers for this special issue by reflecting on the lessons that this crisis has for managers and organizations from both an accountability and accounting perspective.
Predictability in securities price formation: differences between developed and emerging markets
Authors: Camilleri Silvio John , Vassallo Semiramis , Bai Ye 
Published: November 2020

PurposeThis paper examines whether there are differences in the nature of the price discovery process across established versus emerging stock markets using a twenty-country sample.Design/methodology/approachThe authors analyse security returns for traces of predictability or non-randomness using variance ratio tests, Granger-Causality models and runs tests.FindingsThe findings pinpoint at predictabilities which seem inconsistent with market efficiency, and they suggest that the inherent cause of predictability differs across groups.Research limitations/implicationsThe authors present empirical evidence which may be used to attain a deeper understanding of the links between predictability and market efficiency, in view of the conflicting evidence in prior literature.Practical implicationsWhilst the pricing process in emerging markets may be hindered by delayed adjustments, in case of established markets it seems that there is a higher tendency for price reversals which could be due to prior over-reactions.Originality/valueThis study presents evidence of substantial differences in predictability across developed and emerging markets which was gleaned through the rigorous application of different empirical tests.
Customers’ awareness and knowledge level of fraudulent acts in electronic banking in Ghana: evidence from a universal bank
Authors: Amoh John Kwaku , Awunyo-Vitor Dadson , Ofori-Boateng Kenneth 
Published: November 2020

Purpose
This study aims to assess customers’ awareness and level of knowledge on electronic banking fraud.

Design/methodology/approach
A well-structured interviewer-assisted questionnaire was used to collect data from 400 clients of a case study bank. Data were analysed using descriptive statistics. Kendall’s coefficient of concordance (W) statistic was also estimated to track and rank the fraudulent activities identified by the respondents with respect to electronic banking.

Findings
This study found that respondents were aware of most of the specific forms of electronic banking fraud. Firstly, automated teller machinfraud is the most common scam for which customers are aware of. Secondly, institutional factors such as lack of monitoring and education of clients are major factors which expose the bank and clients to fraudulent electronic banking acts. Thirdly, the most effective action that can be taken to prevent fraud in the bank is increased security and personal identification number (PIN) protection education.

Research limitations/implications
This study focusses on a universal bank and uses data from customers of only one branch of the bank to achieve the research objectives.

Originality/value
One uniqueness of this paper is in the adoption of Kendall’s coefficient of concordance (W) statistic to track and rank fraudulent banking activities. The findings will allow financial institutions to know the forms of current and innovative electronic banking fraudulent activities that customers are aware of. It will also enable the banks to find ways to inform their clients about emerging electronic banking fraudulent activities to prevent them from falling victims.
Corporate governance performance and financial statement fraud: evidence from Malaysia
Authors: Md Nasir Noorul Azwin , Hashim Hafiza Aishah 
Published: November 2020

Purpose
This paper aims to review the performance of corporate governance practices in Malaysia from the beginning of the 21st century until recently. This paper also highlights the history of corporate governance practices in Malaysia and the country’s financial statement fraud situation.

Design/Methodology/Approach
Malaysia is a multi-ethnic society that requires managing corporations and firms collectively. Hence, corporate governance practices and good practices are compelled to fit society’s uniqueness. This paper used the survey findings generated from the Corporate Governance Watch Report (CG Watch Report) by the Credit Lyonnais Securities Asia and the Asian Corporate Governance Association from the year 2002 to the year 2018 and discussed the corporate governance performance related to financial statement fraud in Malaysia. The market ranking survey oversees five categories of corporate governance scores: rules and regulations, enforcement, political/regulatory environment, adoption of International Generally Accepted Accounting Principle and corporate governance culture

Findings
The findings reported that firms in Malaysia have benefited from good laws and regulations through corporate governance reforms.

Practical Implications
This study’s findings are relevant to regulators, board members, shareholders, potential investors, analysts and others to produce more informative timely comparisons. Future research should consider analysing and comparing the corporate governance performance in Malaysia with the corporate governance performance of other countries in Asia.

Originality Value
This study summarized the findings generated from a periodical CG Watch Report from the year 2003 to 2018. This study also underlined the actions of responsible agencies and regulatory bodies determined to have a decent corporate governance practice in Malaysia, especially in minimizing financial statement fraud occurrence in the country.
Advertising and marketing archives and ephemera at the Harvard libraries: discovery and opportunity
Authors: Beard Fred , Petrotta Brian 
Published: November 2020

Purpose
A series of online searches of the Harvard University Library System – which includes the Baker Library, Houghton Library and the Radcliffe Institute’s Arthur and Elizabeth Schlesinger Library – on the History of Women in America revealed nearly 1,000 archive and manuscript holdings on advertising and related topics. This paper aims to investigate the extent of these holdings, to assess their value to advertising and marketing historians and to explore their potential for encouraging future research on under-investigated topics and questions.

Design/methodology/approach
Described are the extensive and valuable special collections and other holdings related to advertising, business and marketing of the Harvard Library System. Also described are the availability of the holdings and recommendations for accessing and studying the collections and artifacts.

Findings
The research reported here supports an overall conclusion that the Harvard Library System holds an important place among the world’s repositories of valuable historical advertisements and marketing ephemera. The research also supports four specific conclusions regarding the historical value of Harvard’s collections and archives. First, some of the collections offer access to artifacts and items from an under-investigated period – the first half of the 19th century. Second, many of the collections are international in scope. Third, the collections represent a wide array of 19th century non-periodical advertisements and ephemera, such as trade cards, posters and theatrical playbills. Fourth, and most important, the collections offer significant potential for addressing, among other under-investigated topics, the important role of women in the development of modern advertising theory and professional practices.

Originality/value
A prior search for the world’s largest and most historically significant archives and collections of advertisements and marketing ephemera (promotional objects or media executions created for a one-time, limited purpose) revealed a handful of library and museum collections of exceptional size or topical importance meriting further investigation. This paper adds to an extensive line of research published in the marketing and advertising historical literature exploring and describing the breadth, depth and historical value of the world’s important collections of historical advertisements and ephemera.
The Double Irish and Dutch Sandwich strategies and tax avoidance in Mauritius
Authors: Beebeejaun Ambareen 
Published: November 2020

Purpose
The purpose of this paper is to analyze the Double Irish and Dutch Sandwich (DIDS) tax schemes used by international companies. Companies using these schemes are enabled to transfer a large amount of their profits to offshore tax havens by using wholly owned subsidiaries located in Ireland and the Netherlands. This paper also analyzes the US General Anti-Avoidance Rule (GAAR) to see whether it can effectively detect and counteract this scheme. This analysis is furthermore enhanced by applying the Mauritian GAAR through Section 90 of the Income Tax Act to the said schemes.

Design/methodology/approach
Concerning research methods, the library and the internet will be the main sources of information to be used for this paper. Through the usage of library research, the Mauritian Income Tax Act, US GAAR, European Commission decisions and scholar writings will further enhance this paper on the structure and preventive actions that can be taken against the DIDS scheme. This paper will also use a case study coupled with a theoretical analysis of current anti-avoidance rules.

Findings
The paper then concludes that it is possible to counteract the schemes using the Mauritian law but under specific circumstances. It is then revealed that there is a fundamental flaw in the current tax systems, which is the inability to regulate the intangible nature of resources and technology-based transactions.

Originality/value
To the author's knowledge, this paper is among the first literature on the subject of DIDS strategies conducted in the context of Mauritius.
Workspace transitions: conceptualizing and measuring person–space fit and examining its role in workplace outcomes and social network activity
Authors: Bankins Sarah , Tomprou Maria , Kim ByeongJo 
Published: November 2020

PurposeAlthough the physical environment provides an important context for employees' work, there remain divergent findings regarding how different spatial settings, such as more open or more closed workspaces, impact employees. Employing research on the functions of the physical work environment, we contribute to a growing body of research on employees' interactions with their workspace by developing and measuring the notion of person–space fit (P-S fit). This construct affords examination of the multi-dimensional nature of employees' interactions with their workspaces, to understand how their perceived fit with the key functions of their workspace impacts their experiences and social network activity at work.Design/methodology/approachWe first develop a new P-S fit scale and test its factorial, convergent, discriminant, and incremental validity over other person–environment fit concepts (N = 155). Next, in a naturally-occurring, quasi-field experiment of a workspace change intervention moving employees from predominantly closed workspace to more open workspace (N = 47 pre-move;N = 37 post-move), we examine how changes in both workspace layout and P-S fit impact workers' experiences of their workspaces (needs for task privacy and spaciousness) and collaborative behaviors (social network activity).FindingsOur P-S fit scale consists of theoretically and empirically validated dimensions representing fit with four workspace functions: aesthetic fit; identity fit; instrumental fit; and collaboration fit. Instrumental fit is positively associated with experiences of task privacy, whereas aesthetic fit and identity fit positively associated with experiences of spaciousness, but no forms of fit were related to social network activity. However, the findings show that work-related social network ties tended to decrease, and new ones were less likely to form, in open office spaces.Originality/valueContributing to a growing body of research linking person–environment fit literature to workspace design, this study offers a new scale assessing P-S fit and provides some empirical evidence of its importance for understanding the complexity of the employee-work environment interaction.