bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Patients with Niemann Pick Disease Type C Diagnosed in the Seventh Decade of Life
Authors: Wu Melanie , Ceponiene Rita , Bayram Ece , Litvan Irene 
Published: September 2020

ABSTRACTBackgroundNiemann‐Pick disease type C (NPC) is a rare, autosomal recessive lysosomal lipid storage disorder. It may present with cerebellar ataxia, vertical supranuclear gaze palsy, and cognitive impairment, and the age of symptom onset in adult‐onset NPC is usually earlier than the fourth decade.CasesWe present 2 patients with adult‐onset NPC diagnosed in the seventh decade of life. The slow motor progression and subtle findings of supranuclear vertical gaze palsy and ataxia can lead to a delayed diagnosis and misdiagnosis with parkinsonian disorders, particularly progressive supranuclear palsy.ConclusionThis report highlights and differentiates key clinical characteristics between NPC and parkinsonian disorders. It is important to consider NPC in the differential diagnosis when patients present with slowed vertical saccades, vertical supranuclear gaze palsy, ataxia, and cognitive impairment present at any age. This will allow appropriate and prompt treatment with miglustat and novel experimental therapies.
Age at Onset ofLRRK2p.Gly2019SerIs Related to Environmental and Lifestyle Factors
Authors: Lüth Theresa , König Inke R. , Grünewald Anne , Kasten Meike , Klein Christine , Hentati Faycel , Farrer Matthew , Trinh Joanne 
Published: September 2020

ABSTRACTObjectivesThe effect of environmental and lifestyle factors on patients with LRRK2 (leucine‐rich repeat kinase 2) p.Gly2019Ser (LRRK2+/PD+) compared to idiopathic PD (iPD) has yet to be thoroughly investigated.MethodsIn a homogeneous Tunisian Arab Berber population, we recruited 200 idiopathic PD and 199 LRRK2 p.Gly2019Ser mutation carriers, of whom 142 had PD (LRRK2+/PD+) and 57 were unaffected (LRRK2+/PD−). Case report form (CRF) questionnaires (motor and non‐motor symptoms) including the Geoparkinson Questionnaire were used to assess environmental and lifestyle factors.ResultsIn LRRK2+/PD+, tobacco use was significantly associated with a later median age at onset (AAO). The median AAO was 60 years (interquartile range = 52–67.25) for tobacco users, compared to 52 years (interquartile range = 45.25–61) for non‐users (P= 0.0042 at adjusted α = 0.025). Additionally, we observed an independent but additive effect of black tea consumption and tobacco use.ConclusionsOur data suggest that tobacco and black tea have a protective effect on age at onset in LRRK2+/PD+. © 2020 The Authors.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Identification and Characterization of IgE‐Reactive Proteins and a New Allergen (Cic a 1.01) from Chickpea (Cicer arietinum)
Authors: Wangorsch Andrea , Kulkarni Anuja , Jamin Annette , Spiric Jelena , Bräcker Julia , Brockmeyer Jens , Mahler Vera , Blanca‐López Natalia , Ferrer Marta , Blanca Miguel , Torres Maria , Gomez Paqui , Bartra Joan , García‐Moral Alba , Goikoetxea María J. , Vieths Stefan , Toda Masako , Zoccatelli Gianni , Scheurer Stephan 
Published: September 2020

ScopeChickpea (Cicer arietinum) allergy has frequently been reported particularly in Spain and India. Nevertheless, chickpea allergens are poorly characterized. The authors aim to identify and characterize potential allergens from chickpea.Methods and ResultsCandidate proteins are selected by an in silico approach or immunoglobuline E (IgE)‐testing. Potential allergens are prepared as recombinant or natural proteins and characterized for structural integrity by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE), circular dichroism (CD)‐spectroscopy, and mass spectrometry (MS) analysis. IgE‐sensitization pattern of Spanish chickpea allergic and German peanut and birch pollen sensitized patients are investigated using chickpea extracts and purified proteins. Chickpea allergic patients show individual and heterogeneous IgE‐sensitization profiles with extracts from raw and boiled chickpeas. Chickpea proteins pathogenesis related protein family 10 (PR‐10), a late embryogenesis abundant protein (LEA/DC‐8), and a vicilin‐containing fraction, but not 2S albumin, shows IgE reactivity with sera from chickpea, birch pollen, and peanut sensitized patients. Remarkably, allergenic vicilin, DC‐8, and PR‐10 are detected in the extract of boiled chickpeas.ConclusionSeveral IgE‐reactive chickpea allergens are identified. For the first time a yet not classified DC‐8 protein is characterized as minor allergen (Cic a 1). Finally, the data suggest a potential risk for peanut allergic patients by IgE cross‐reactivity with homologous chickpea proteins.
A compact ultra‐wideband transverse electromagnetic mode horn antenna for high power microwave applications
Authors: Yadav Swati Varun , Chittora Ashish 
Published: September 2020

AbstractA compact ultra‐wideband transverse electromagnetic mode (TEM) horn antenna for high power microwave (HPM) application is proposed. The designed antenna is capable of transmitting ultra‐wideband pulse signals without an electric breakdown. An exponentially tapered profile structure is used to match the characteristics impedance between the feed line and free space for wideband. It is fed by a 50 Ω N‐type connector. The antenna operates between 2.7 GHz to 12.5 GHz frequency ranges. The simulated and measured reflection coefficient (S11) is below −10 dB over the entire UWB band. The proposed structure also receives a directive radiation pattern, and it has a high gain of up to 8.57 dBi. This antenna can handle up to 54 MW HPM signals without breakdown. It is compact, light‐weight, and easy to fabricate. Therefore, it can be used for portable and airborne HPM systems.
Refining acculturation measures for health research: Latina/o heterogeneity in the National Latino and Asian American Study
Authors: Roth Kimberly B. , Musci Rashelle J. , Eaton William W. 
Published: September 2020

AbstractObjectivesThis study factor analyzes six scales relating to acculturation and related experiences among a nationally representative sample of United States‐residing Latina/os (n = 2,541) from the National Latino and Asian American Study (NLAAS), using measurement invariance (MI) testing to explore differences in latent constructs by Latina/o subgroup.MethodsFactor Analysis (FA) within an Exploratory Structural Equation Modeling framework was used to analyze the factor structure of six scales measuring acculturation and related experiences (i.e., acculturation [language use and preference], enculturation [ethnic identity], discrimination, neighborhood context, and family environment). We tested for MI by two important Latina/o subgroups: ethnic heritage and generational status.ResultsThe underlying latent factors resulting from FA strongly aligned with the NLAAS subscales. No scale achieved full MI, yet the degree to which MI held varied greatly by scale and by subgroup.ConclusionsFindings show that Latina/os are heterogeneous, but that this often depends on the construct and subgrouping of interest. Future research should use these scales in a latent framework, accounting for the lack of MI, to ensure that the underlying acculturative constructs of interest are validly measured when investigating their association with mental health outcomes in this population.
Estimating the Effects of Environmental Variables and Gear Type on Panfish Catch and Bycatch in Reservoirs
Authors: Porta Michael J. , Stewart David R. , Snow Richard A. 
Published: September 2020

Abstract
Panfish populations create some of the most popular and intensively managed recreational fisheries in North America. However, sampling biases may prevent fisheries managers from making informed decisions. Typically, panfish are collected using fyke nets; however, hoop nets also may be effective for capturing these species. Information regarding the most efficient and least biased approach for sampling panfish would allow fishery managers to collect the highest quality data for their management. We used three gear types (standard North American-design fyke net, 13-mm-mesh hoop nets, and 25-mm-mesh hoop nets) to compare the catch rates and size structure of panfish (Bluegill Lepomis macrochirus, Redear Sunfish L. microlophus, and White Crappie Pomoxis annularis), total bycatch, effects of environmental factors on catch and bycatch, and sampling efficiency (number of nets needed to achieve a relative SE ≤ 25% [RSE25]). Target panfish species dominated the catch (91–94%) and nontarget bycatch rates were low (6–9%) irrespective of gear type. We observed considerable variability in relative abundance, size structure, and number of nets needed to achieve RSE25, which differed by species and gear type. Detection probabilities for Bluegill and White Crappie were greatest when using 13-mm-mesh hoop nets, but detection probabilities for Redear Sunfish did not differ across gear types. Environmental variables influenced panfish detection and abundance, as lower water temperature and increased depth generally resulted in decreased detection probabilities and abundance of target panfish. The standard fyke net captured panfishes at greater rates and of broader size structures than both hoop-net designs and appeared to be the most efficient method for collecting Bluegill, Redear Sunfish, and White Crappie in this study. While hoop nets have great utility for sampling panfishes, they may not efficiently capture enough fish in some cases to support informed management decisions.
Assigning Fates in Telemetry Studies Using Hidden Markov Models: an Application to Deepwater Groupers Released with Descender Devices
Authors: Runde Brendan J. , Michelot Théo , Bacheler Nathan M. , Shertzer Kyle W. , Buckel Jeffrey A. 
Published: September 2020

Abstract
Fate assignment is crucial to the results of survival studies, particularly those that utilize acoustic tagging. Most current methodologies are at least partially subjective; thus, having a means of objectively assigning fates would improve the precision, accuracy, and utility of such studies. We released 57 acoustically tagged fish belonging to six deepwater grouper species off North Carolina, USA, via surface release and recompressed release with descender devices. We applied a three-state hidden Markov model (HMM) in a novel way: to distinguish movement patterns between fish that were alive and fish that were dead (and might have been eaten by predators). We assigned fates using two approaches that differed in their reliance on HMMs. When HMMs were the predominant source of fate assignment, we estimated survival of 40 deepwater groupers released with descender devices at the continental shelf break (66–120-m depth) to be 0.46 (95% CI = 0.33–0.65). When a combination of HMMs and prior information was utilized, we estimated survival of the same 40 groupers to be 0.61 (95% CI = 0.47–0.80). Both estimates represented a substantial improvement over the survival of surface-released groupers (n = 9; survival ~0.0). Furthermore, HMMs estimated zero survival for an additional five descended groupers at a wreck site in 240-m depth, although one analysis using prior information suggested that survival was possible in that depth. These estimates were aided by the objectivity of HMMs, and we recommend that future survival studies involving acoustic tagging employ similar methodologies. The improved survival of groupers after descending is an important finding for management, as this taxon contains several species of impaired stock status or fishery status.
Pessary evaluation for genital prolapse treatment: From acceptance to successful fitting
Authors: Vasconcelos Camila Teixeira Moreira , Gomes Maria Laura Silva , Geoffrion Roxana , Saboia Dayana Maia , Bezerra Karine de Castro , Vasconcelos Neto José Ananias 
Published: September 2020

AbstractAimsTo determine the percentage of women with symptomatic pelvic organ prolapse who opted for pessary and had a successful pessary fitting trial; to identify the most commonly used size of pessary for stage of prolapse; and to identify risk factors associated with unsuccessful fitting.MethodsWe conducted a prospective cohort study of women with symptoms of genital prolapse referred to a public hospital tertiary care clinic (2013‐2019). We used ring and ring with support pessaries for fittings. We collected patient demographics, pelvic organ prolapse quantification, size of pessary used and evaluated factors associated with pessary fittings. We defined unsuccessful fit as failure to continue pessary use at 4 weeks post fitting trial. We used Mann‐Whitney and χ2 tests to compare variables between groups of successfully and unsuccessfully fitted. Using logistic regression, we built a prediction model for unsuccessful fit.ResultsAll 170 women with symptomatic prolapse referred to our clinic accepted to undergo a pessary fitting. More than 70% (n = 124/72.9%) were successfully at 4 weeks. We used an average of 1.7 pessaries (range: 1‐6) per patient to identify the best‐fitting pessary and #2, 5, 3, 7, and 4 were the sizes commonly used (78.2%). Women with body mass index ≥30 kg/m2 (odds ratio [OR]: 4.74; 95% confidence interval [CI], 1.98‐11.32; P < .001), total vaginal length <7.5 cm (OR: 3.78; 95% CI, 1.98‐11.32; P < .001), and sexually active women (OR: 2.26; 95% CI, 1.04‐4.91; P = .035) were associated with increased unsuccessful fitting.ConclusionThe vaginal pessary proved to be an excellent choice, with high acceptance and successful fitting rates.
Cold wind of change: Associations between organizational change, turnover intention, overcommitment and quality of care in Spanish and Swedish eldercare organizations
Authors: Lundmark Robert , Nordin Maria , Yepes‐Baldó Montserrat , Romeo Marina , Westerberg Kristina 
Published: September 2020

AbstractAimTo examine the association between organizational change, turnover intentions, overcommitment and perceptions of quality of care among nurses and nursing assistants employed in eldercare organizations.DesignA longitudinal survey (baseline, 12‐month follow‐up) was used.MethodsA panel sample of 226 eldercare employees in Spain and Sweden responded to survey questions concerning organizational change, turnover intentions, overcommitment and perceptions of quality of care. The data were analysed using structural equational modelling.ResultsWe found a statistically significant positive relationship between organizational change, employees’ turnover intention and overcommitment. We also found a statistically significant negative relationship between organizational change and perceived quality of care.
Compact difference scheme for two‐dimensional fourth‐order nonlinear hyperbolic equation
Authors: Li Qing , Yang Qing , Chen Huanzhen 
Published: September 2020

AbstractHigh‐order compact finite difference method for solving the two‐dimensional fourth‐order nonlinear hyperbolic equation is considered in this article. In order to design an implicit compact finite difference scheme, the fourth‐order equation is written as a system of two second‐order equations by introducing the second‐order spatial derivative as a new variable. The second‐order spatial derivatives are approximated by the compact finite difference operators to obtain a fourth‐order convergence. As well as, the second‐order time derivative is approximated by the central difference method. Then, existence and uniqueness of numerical solution is given. The stability and convergence of the compact finite difference scheme are proved by the energy method. Numerical results are provided to verify the accuracy and efficiency of this scheme.
A new type of full multigrid method for the elasticity eigenvalue problem
Authors: Xu Fei , Huang Qiumei , Ma Hongkun 
Published: September 2020

AbstractThis paper introduces a new type of full multigrid method for the elasticity eigenvalue problem. The main idea is to avoid solving large scale elasticity eigenvalue problem directly by transforming the solution of the elasticity eigenvalue problem into a series of solutions of linear boundary value problems defined on a multilevel finite element space sequence and some small scale elasticity eigenvalue problems defined on the coarsest correction space. The involved linear boundary value problems will be solved by performing some multigrid iterations. Besides, some efficient techniques such as parallel computing and adaptive mesh refinement can also be absorbed in our algorithm. The efficiency and validity of the multigrid methods are verified by several numerical experiments.
Knock‐knees: Identifying genu valgum and understanding its relationship to vitamin D deficiency in 18th to 19th century northern England
Authors: Tschinkel Khrystyne , Gowland Rebecca 
Published: September 2020

AbstractGenu valgum is a condition in which a person's knees angle inwards and touch one another creating a “knock‐kneed” appearance during life and potentially causing pain and walking difficulties. The most common cause of genu valgum is medial torsion of the proximal tibia, such that the lateral side becomes more weight bearing. It is considered a feature of vitamin D deficiency and many other pathological conditions. Currently, bioarchaeologists lack clear diagnostic criteria to identify genu valgum in skeletal remains, and it is therefore likely to be underreported. The aim of this study was to develop a method for diagnosing genu valgum and apply it to the analysis of adult skeletons from two 18th to 19th century skeletal collections from the North of England. Six individuals from Coach Lane and three from Fewston showed evidence of genu valgum. All of these individuals had other skeletal indicators of vitamin D deficiency. We discuss the relationship between vitamin D deficiency and genu valgum alongside other possible etiologies identified in the clinical literature. The individuals who presented with vitamin D deficiency related genu valgum in this study were diagnosed with adolescent rickets. Individuals who were vitamin D deficient in early childhood were more likely to be vitamin D deficient later in life and exhibit more advanced genu valgum. Genu valgum is often overlooked in the palaeopathological literature but its presence may be an important indicator of broader health problems.
Neuro‐aesthetics and the iconography in photography
Authors: Jokeit Hennric , Blochwitz Daniel 
Published: September 2020

AbstractCan neurosciences explain art? No, but it can help us to understand why some images are more memorable and, thus, more successful than others. This article aims to identify certain factors that may influence the artistic success of photographic images. These factors are discussed within the contexts of basic neuropsychological concepts, visual perception, and visual memory. A new computational and neuroscientifically based model, the predictive coding theory, provides a powerful framework for integrating social and individual factors that influence aesthetic experience and activity. A case study of Dorothea Lange's iconic photograph Migrant Mother demonstrates the importance of identifiable factors that influence and determine a photograph's potential success. We are convinced that a future systemic approach will enable the complementary integration of neuroscientific, perceptual, cognitive, emotional, and sociopsychological insights through the framework of predictive coding theory with socioscientific, art‐theoretical, and art‐historical as well as neuro‐ and behavioral‐economical models.
The angrier or the happier the more creative? The impact of anger and joy induction on creative problem‐solving and divergent thinking
Authors: Zhan Jun , Jiang Shuang , Luo Jing 
Published: September 2020

AbstractIn contrast to the conventional reasoning process that relies heavily on cognitive control, an individual's creativity may show an increasing trend when the cognitive control function is suppressed. A typical situation in which this occurs is low cognitive inhibition triggered by strong anger. In studies of the influence of anger on creativity, the creative tasks used were mostly divergent‐thinking tasks, and few studies have compared the impact of anger and joy on general thinking and creative thinking directly. In addition to using an Alternative‐Uses Task (AUT) that reflects divergent thinking, this study also adopted the matching routine and novel chunk‐decomposition tasks to evaluate general and novel problem‐solving, respectively. We also focused on the impact of angry and joy moods on creative tasks, comparing them with a control condition of neutral mood. The results revealed that the induction of an anger emotion promotes an individual's divergent thinking more than that of a joy emotion, and that both anger and joy are effective ways for creative problem‐solving. Furthermore, anger reduced the reaction time while joy increased the accuracy rate to facilitate the creative problem‐solving.
Is there a role for fetal interventions in gastroschisis management? – An updated comprehensive review
Authors: Willborg Brooke E. , Ibirogba Eniola R. , Trad Ayssa Teles Abrao , Sbragia Lourenço , Potter Dean , Ruano Rodrigo 
Published: September 2020

AbstractWe conducted a comprehensive evidence‐based review on the epidemiology and current standard of care of gastroschisis management as well as the pathophysiology, rationale and feasibility of fetal therapy as a viable alternative. Gastroschisis is a periumbilical abdominal wall defect characterized by abdominal viscera herniation in utero. It affects 4 in 10 000 live births, but the prevalence has steadily increased in recent years. Gastroschisis is typically diagnosed on routine second‐trimester ultrasound. The overall prognosis is favorable, but complex gastroschisis, which accounts for about 10% to 15% of cases, is associated with a higher mortality, significant disease burden and higher healthcare costs due to long‐ and short‐term complications. The current standard of care has yet to be established but generally involves continued fetal surveillance and multidisciplinary perinatal care. Postnatal surgical repair is achieved with primary closure, staged silo closure or sutureless repair. Experimental animal studies have demonstrated the feasibility of in utero closure, antiinflammatory therapy and prenatal regenerative therapy. However, reports of early preterm delivery and amnioinfusion trials have failed to show any benefit in humans. Further experimental studies and human trials are necessary to demonstrate the potential benefit of fetal therapy in gastroschisis.
Artificial placenta and womb technology: Past, current, and future challenges towards clinical translation
Authors: De Bie Felix R. , Davey Marcus G. , Larson Abby C. , Deprest Jan , Flake Alan W. 
Published: September 2020

AbstractExtreme prematurity remains a major cause of neonatal mortality and severe long‐term morbidity. Current neonatal care is associated with significant morbidity due to iatrogenic injury and developmental immaturity of extreme premature infants. A more physiologic approach, replacing placental function and providing a womb‐like environment, is the foundational principle of artificial placenta (AP) and womb (AW) technology. The concept has been studied during the past 60 years with limited success. However, recent technological advancements and a greater emphasis on mimicking utero‐placental physiology have improved the success of experimental models, bringing the technology closer to clinical translation. Here, we review the rationale for and history of AP and AW technology, discuss the challenges that needed to be overcome, and compare recent successful models. We conclude by outlining some remaining challenges to be addressed on the path towards clinical translation and opportunities for future research.