bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complicações vasculares e fatores relacionados a sua ocorrência após procedimentos hemodinâmicos percutâneos
Authors: Santos Ana Carolina Pessoa , Ambiel Maria Letícia Bannwart , Ferreria Elaine Barros , Rocha Priscilla Roberta Silva 
Published: November 2020

Objetivo: investigar as complicações vasculares em pacientes submetidos a procedimentos hemodinâmicos percutâneos e identificar fatores relacionados a sua ocorrência. Método: estudo retrospectivo em um hospital cardiológico, com pacientes que evoluíram com danos vasculares, entre janeiro de 2015 e dezembro de 2016. Os dados foram obtidos pela coleta em prontuários e analisados de forma descritiva e analítica. Resultados: foram incluídos 93 pacientes, a maioria idosos, do sexo masculino e portadores de hipertensão. A taxa de complicação vascular foi de 3%, o hematoma local foi o mais frequente (86%). O sexo feminino foi associado à ocorrência de danos vasculares mais graves como o hematoma retroperitoneal e o pseudoaneurisma (p=0,04). Conclusão: dentre as complicações vasculares, o hematoma foi o mais frequente e o sexo feminino foi fator preditor de risco, associado a injúrias mais graves. Reconhecer os fatores preditores de risco auxilia a assistência direcionada às necessidades individuais do paciente.
Educational Potential of Multicultural Language Teaching (on the Russian Language Teaching Experience)
Authors: Gennadievna Shtyrlina Ekaterina , Sergeevna Palekha Ekaterina , Vladimirovna Kapralova Julia 
Published: November 2020

The educational potential of the language teaching environment does not often become the object of a special scientific description due to several objective reasons. The model of subject-subject educational relations between the Teacher and the Student in the conditions of the multicultural educational environment is analyzed in this article. This model is focused on supporting the relative autonomy of the individual in the process of teaching within the pedagogical process and is aimed at creating conditions that ensure the formation of humanistic value orientations based on the principle of cultural appropriateness.
The article emphasizes the equivalence of the positions of participants in the educational space, the need to build a psychologically comfortable and humanistic interaction between them. The authors note that a new type of educational interaction should be of a dialogical nature and should be based on the principles of pedagogy of cooperation. Dialogue as the main form of interaction between subjects of the educational process implies a meeting of positions and points of view, in the process of which the views, ideas, opinions that could form the personality are determined, specified, enriched and transformed. The socio-cultural aspect of dialogue is important, where the dialogue participants are interpreted as the subjects of the dialogue of cultures.
The discursive model of learning allows us to consider the text as a means of involving the individual in the cultural heritage and spiritual values of one's own and other peoples (from text to culture and from culture to text). Using the pedagogical potential of the text, the teacher contributes to the formation of the learner’s necessary general educational competencies and his socio-cultural worldview. The article concludes that the educational text can be considered not only as a didactic unit but also as a unit for modeling cultural code, as a key tool for the formation of a person's spiritual culture of the learner.
Adjectival Phraseological Units with the Parametric Component
Authors: A. Yarullina Olesya , R. Kayumova Albina , Pamies Bertrán Antonio 
Published: November 2020

The article is devoted to the comparative study of the Tatar and English adjectival phraseological units with the parametric component. Structural and semantic peculiarities are taken into consideration. The main methods of research are those of general linguistic methods and special linguistic methods. The purpose of the article is to find out common and specific features of the adjectival phraseological units with the parametric components in the English and Tatar languages. The investigation is based on the material from English and Tatar monolingual and polylingual dictionaries. The adjectival phraseological units of the Tatar language have not been studied enough. The Tatar and the English languages are structurally different and the study of the adjectival phraseological units with the parametric component is of great interest. Comparative and non-comparative adjectival phraseological units with parametric components have been analyzed in the article, the frequency of the structures in both of the languages was found out and the explanation of the phenomenon was searched for. Semantically the adjectival phraseological units with the parametric component may express negative or positive attitude to reality, spheres of life, communicative process, or to a person, and that depends on the usage of this or that parametric adjective of the antonymic pair. General and specific features have been found out as well as exceptions. Based on the data got from the research the conclusions on the structure and semantics of the adjectival phraseological units with the parametric component are presented in the article.
Improving decolorization of dyes by laccase from Bacillus licheniformis by random and site-directed mutagenesis
Authors: Bu Tongliang , Yang Rui , Zhang YanJun , Cai Yuntao , Tang Zizhong , Li Chenglei , Wu Qi , Chen Hui 
Published: November 2020

Background
Dye wastewater increases cancer risk in humans. For the treatment of dyestuffs, biodegradation has the advantages of economy, high efficiency, and environmental protection compared with traditional physical and chemical methods. Laccase is the best candidate for dye degradation because of its multiple substrates and pollution-free products.

Methods
Here, we modified the laccase gene of Bacillus licheniformis by error-prone PCR and site-directed mutagenesis and expressed in E. coli. The protein was purified by His-tagged protein purification kit. We tested the enzymatic properties of wild type and mutant laccase by single factor test, and further evaluated the decolorization ability of laccase to acid violet, alphazurine A, and methyl orange by spectrophotometry.

Results
Mutant laccase Lacep69and D500G were superior to wild type laccase in enzyme activity, stability, and decolorization ability. Moreover, the laccase D500G obtained by site-directed mutagenesis had higher enzyme activity in both, and the specific activity of the purified enzyme was as high as 426.13 U/mg. Also, D500G has a higher optimum temperature of 70 °C and temperature stability, while it has a more neutral pH 4.5 and pH stability. D500G had the maximum enzyme activity at a copper ion concentration of 12 mM. The results of decolorization experiments showed that D500G had a strong overall decolorization ability, with a lower decolorization rate of 18% for methyl orange and a higher decolorization rate of 78% for acid violet.

Conclusion
Compared with the wild type laccase, the enzyme activity of D500G was significantly increased. At the same time, it has obvious advantages in the decolorization effect of different dyes. Also, the advantages of temperature and pH stability increase its tolerance to the environment of dye wastewater.
Gene signature for prognosis in comparison of pancreatic cancer patients with diabetes and non-diabetes
Authors: Yang Mingjun , Song Boni , Liu Juxiang , Bing Zhitong , Wang Yonggang , Yu Linmiao 
Published: November 2020

BackgroundPancreatic cancer (PC) has much weaker prognosis, which can be divided into diabetes and non-diabetes. PC patients with diabetes mellitus will have more opportunities for physical examination due to diabetes, while pancreatic cancer patients without diabetes tend to have higher risk. Identification of prognostic markers for diabetic and non-diabetic pancreatic cancer can improve the prognosis of patients with both types of pancreatic cancer.MethodsBoth types of PC patients perform differently at the clinical and molecular levels. The Cancer Genome Atlas (TCGA) is employed in this study. The gene expression of the PC with diabetes and non-diabetes is used for predicting their prognosis by LASSO (Least Absolute Shrinkage and Selection Operator) Cox regression. Furthermore, the results are validated by exchanging gene biomarker with each other and verified by the independent Gene Expression Omnibus (GEO) and the International Cancer Genome Consortium (ICGC). The prognostic index (PI) is generated by a combination of genetic biomarkers that are used to rank the patient’s risk ratio. Survival analysis is applied to test significant difference between high-risk group and low-risk group.ResultsAn integrated gene prognostic biomarker consisted by 14 low-risk genes and six high-risk genes in PC with non-diabetes. Meanwhile, and another integrated gene prognostic biomarker consisted by five low-risk genes and three high-risk genes in PC with diabetes. Therefore, the prognostic value of gene biomarker in PC with non-diabetes and diabetes are all greater than clinical traits (HR = 1.102,P-value < 0.0001; HR = 1.212,P-value < 0.0001). Gene signature in PC with non-diabetes was validated in two independent datasets.ConclusionsThe conclusion of this study indicated that the prognostic value of genetic biomarkers in PCs with non-diabetes and diabetes. The gene signature was validated in two independent databases. Therefore, this study is expected to provide a novel gene biomarker for predicting prognosis of PC with non-diabetes and diabetes and improving clinical decision.
The development and evaluation of an online educational tool for the evidence-based management of neck pain by chiropractic teaching faculty
Authors: Verville Leslie , DC Pierre Côté , Grondin Diane , DC Silvano Mior , Kay Robin 
Published: November 2020

Objective
To develop an online, interactive educational tool to deliver an evidence-based clinical practice guideline to faculty members at a Canadian chiropractic college. Second, to evaluate the learning, design, and engagement constructs of the tool in a sample of chiropractic faculty members.

Methods
Using an integrated knowledge translation methodology and the Knowledge to Action Framework, we developed an evidence-based online learning tool. The context of the tool focused on a clinical practice guideline on the management of neck pain. We evaluated the learning, design, and engagement constructs in a sample of faculty members and residents using the Learning Object Evaluation Scale for Students. Participants were also asked to provide suggestions for improvement of the tool.

Results
Sixteen participants completed the evaluation. Most (68.8%) participants were chiropractors, 75% were male and 56% were between the ages of 25 and 44 years. At least 75% of participants agreed that the learning, design, and engagement constructs of the learning tool were adequate. The open-ended suggestions unveiled 3 pedagogical themes, relating to multimedia, thinking skills, and learner control, within the tool that could benefit from further development. These themes informed recommendations to improve the tool.

Conclusion
Our online, interactive, module-based learning tool has sound pedagogical properties. Further research is needed to determine if its use is associated with a change in knowledge.
Partial Purification of a Catalase from an Improved Nigerian Sorghum Grain Variety
Authors: Nnamchi C. I. , Nwanguma B. C. , Amadi O. C. 
Published: November 2020

Catalases are key components of cellular detoxification pathways that prevent the formation of highly reactive hydroxyl radicals through catalyzing the decomposition of hydrogen peroxide into water and molecular oxygen. Their presence in brewery grains prevent the inactivation of important brewery enzymes and also stop lipid peroxidation. To determine their occurrence and establish some of its properties in sorghum, which has become as an important brewery grain similar to barley, crude catalase was obtained from a sorghum grain variety. Preliminary purification of catalase from the sorghum grain variety used, NRL-3, showed that the enzyme was purified 3.2-fold from the crude protein to give a 49% yield of the partially purified enzyme, with a final specific activity of 32 Umg-1 proteins. There was also a positive indication of sorghum catalase presence on SDS PAGE with positive bands occurring between the range of 48-62 kDa. Therefore, the molecular weight of sorghum catalase most likely falls within the two bands. The enzyme showed a narrow pH range with optimum activity occurring at pH 7. Similarly, its optimum activity temperature occurred at 40°C. This work is the first reported attempt at purifying catalase from sorghum.
Awareness on Use of Steroid Drugs among Football Players
Authors: Kumaran A. S. Kirthick , Ganapathy Dhanraj , Sasanka L. Keerthi 
Published: November 2020

Steroids are man-made chemicals that resemble hormones that are naturally made in the human body. The main role of steroids in sports is to enhance performance and reduce inflammation. The aim of the present study is to assess the awareness of the use of steroid drugs among football players and the ill effects of steroid drug intake. A Cross-sectional study was done on 100 football players and veterans registered with the State Football Association. A pretested structured questionnaire assessing the awareness on the use of steroid drugs was the survey instrument. Both male and female football players and veterans within the age group 18-50 years were selected after obtaining informed consent. The sampling method used was a simple random sampling method. The questionnaire comprised of 10 open-ended questions and were administered through Google forms. 76% of the participants responded that they use steroid drugs at least once and 24% responded that they never used steroid drugs. According to the above survey, we conclude that there is a high rate of usage of steroid drugs among football players.
Research on the Multisectoral Impact of Infectious Diseases on the Economy
Authors: Shortanov Rustam Anzorovich 
Published: November 2020

The purpose of the work is to consider the features of the multidimensional impact of the consequences of the spread of infectious diseases on the economic development of countries. The author concludes that the process of public health exposure to regional or global new and endemic infectious diseases may have broader socio-economic consequences that are often not taken into account when assessing risk or impact. With the spread of international travel and trade, such events can cause economic shocks that go far beyond the traditional health sectors and the original geographical range of the pathogen.
Intensive economic specialization and a broader division of labor, accompanied by expanding markets and increasing economic globalization, increase the risk of people coming into contact with sources that contribute to highly contagious diseases such as influenza and COVID-19. The adverse economic consequences of new forms or types of these diseases can be serious, taking into account the high degree of interdependence of economic activities in the modern economy. For example, the absence of workers from work due to such infections or the risks of these infections can disrupt production at the workplace level. Also, supply chains can be disrupted or disrupted by these pandemics, and in addition, they usually have a negative impact on aggregate demand for goods. This is evidenced by the COVID-19 outbreak, which led to a serious global economic depression. The occurrence and consequences of epidemics and pandemics depend on the nature and stages of economic development. The economic and social structure of modern society contributes to the transmission of diseases that depend on human contact or presence, especially those that are caused by airborne microbes or persist on commonly used surfaces.
The study concluded that public and private stakeholders at the local, national and international levels should work together to address the economic consequences of infectious diseases, to provide informed systems and risk and impact analysis, and to promote cost-sharing strategies for prevention and preparedness where possible, and to evaluate optimal intervention strategies when necessary. Developments related to infectious diseases in today's globalized world require increased responsibility for preserving people's health and economic security.
Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride
Authors: Nguyen David-Dan , Marchese Maya , Cone Eugene B. , Paciotti Marco , Basaria Shehzad , Bhojani Naeem , Trinh Quoc-Dien 
Published: November 2020

ImportanceThere is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide.ObjectiveTo investigate the association of suicidality (ideation, attempt, and completed suicide) and psychological adverse events (depression and anxiety) with finasteride use.Design, Setting, and ParticipantsThis pharmacovigilance case-noncase study used disproportionality analysis (case-noncase design) to detect signals of adverse reaction of interest reported with finasteride in VigiBase, the World Health Organization’s global database of individual case safety reports. To explore the strength of association, the reporting odds ratio (ROR), a surrogate measure of association used in disproportionality analysis, was used. Extensive sensitivity analyses included stratifying by indication (BPH and alopecia) and age (≤45 and &gt;45 years); comparing finasteride signals with those of drugs with different mechanisms but used for similar indications (minoxidil for alopecia and tamsulosin hydrochloride for BPH); comparing finasteride with a drug with a similar mechanism of action and adverse event profile (dutasteride); and comparing reports of suicidality before and after 2012. Data were obtained in June 2019 and analyzed from January 25 to February 28, 2020.ExposuresReported finasteride use.Main Outcomes and MeasuresSuicidality and psychological adverse events.ResultsVigiBase contained 356 reports of suicidality and 2926 reports of psychological adverse events (total of 3282 adverse events of interest) in finasteride users (3206 male [98.9%]; 615 of 868 [70.9%] with data available aged 18-44 years). A significant disproportionality signal for suicidality (ROR, 1.63; 95% CI, 1.47-1.81) and psychological adverse events (ROR, 4.33; 95% CI, 4.17-4.49) in finasteride was identified. In sensitivity analyses, younger patients (ROR, 3.47; 95% CI, 2.90-4.15) and those with alopecia (ROR, 2.06; 95% CI, 1.81-2.34) had significant disproportionality signals for increased suicidality; such signals were not detected in older patients with BPH. Sensitivity analyses also showed that the reports of these adverse events significantly increased after 2012 (ROR, 2.13; 95% CI, 1.91-2.39).Conclusions and RelevanceIn this pharmacovigilance case-noncase study, significant RORs of suicidality and psychological adverse events were associated with finasteride use in patients younger than 45 years who used finasteride for alopecia. The sensitivity analyses suggest that these disproportional signals of adverse events may be due to stimulated reporting and/or younger patients being more vulnerable to finasteride’s adverse effects.
Visualizing Piezoelectricity on 2D Crystals Nanobubbles
Authors: Wang Wei , Zhou Lijun , Hu Sheng , Novoselov Konstantin S. , Cao Yang 
Published: November 2020

Abstract2D crystals with noncentrosymmetric structures exhibit piezoelectric properties that show great potential for applications in energy conversion and electromechanical devices. Quantitative visualization of piezoelectric field spatial distribution is expected to offer a better understanding of macroscopic piezoelectricity, yet remains to be realized. Here, a technique of mapping piezoelectric potential on 2D materials bubbles based on the measurements of surface potential using kelvin probe force microscope is reported. By using odd number of layers hexagonal boron nitride and MoS2 nanobubbles, strain‐induced piezoelectric potential profiles are quantitatively visualized on the bubbles. The obtained piezoelectric coefficient is 3.4 ± 1.2 × 10−10 C m−1 and 3.3 ± 0.2 × 10−10 C m−1 for hBN and MoS2, in agreement with the values reported. On the contrary, homogeneous distribution of surface potential is measured on even number of layers crystals bubbles where the crystal's inversion symmetry is restored. Using such technique, in situ visualization of photogenerated charge carrier separation under piezoelectric potential is also achieved, which offers a platform of investigating the coupling between piezoelectricity and photoelectric effect, and an approach of tuning piezoelectric field. The present work should aid the understanding of local piezoelectric potential and its various affecting factors including substrate doping and external stimuli, and give insights for designing piezoelectric nanodevices based on 2D nanobubbles.
Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention
Authors: Zhou Xuefei , Liu Xiangrui , Huang Leaf 
Published: November 2020

AbstractMacrophages are one of the most abundant non‐malignant cells in the tumor microenvironment, playing critical roles in mediating tumor immunity. As important innate immune cells, macrophages possess the potential to engulf tumor cells and present tumor‐specific antigens for adaptive antitumor immunity induction, leading to growing interest in targeting macrophage phagocytosis for cancer immunotherapy. Nevertheless, live tumor cells have evolved to evade phagocytosis by macrophages via the extensive expression of anti‐phagocytic molecules, such as CD47. In addition, macrophages also rapidly recognize and engulf apoptotic cells (efferocytosis) in the tumor microenvironment, which inhibits inflammatory responses and facilitates immune escape of tumor cells. Thus, intervention of macrophage phagocytosis by blocking anti‐phagocytic signals on live tumor cells or inhibiting tumor efferocytosis presents a promising strategy for the development of cancer immunotherapies. Here, the regulation of macrophage‐mediated tumor cell phagocytosis is first summarized, followed by an overview of strategies targeting macrophage phagocytosis for the development of antitumor therapies. Given the potential off‐target effects associated with the administration of traditional therapeutics (for example, monoclonal antibodies and small molecule inhibitors), the opportunity for nanomedicine in macrophage phagocytosis intervention is highlighted.