bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natriuretic Effect of Two Weeks of Dapagliflozin Treatment in Patients With Type 2 Diabetes and Preserved Kidney Function During Standardized Sodium Intake: Results of the DAPASALT Trial
Authors: Scholtes Rosalie A. , Muskiet Marcel H.A. , van Baar Michiel J.B. , Hesp Anne C. , Greasley Peter J. , Karlsson Cecilia , Hammarstedt Ann , Arya Niki , van Raalte Daniël H. , Heerspink Hiddo J.L. 
Published: December 2020

OBJECTIVE
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk for heart failure hospitalization potentially by inducing sodium excretion, osmotic diuresis, and plasma volume contraction. Few studies have investigated this hypothesis, but none have assessed cumulative sodium excretion with SGLT2 inhibition during standardized sodium intake in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
The DAPASALT trial was a mechanistic, nonrandomized, open-label study in patients with type 2 diabetes with preserved kidney function on a controlled standardized sodium diet (150 mmol/day). It evaluated the effects of dapagliflozin on sodium excretion, 24-h blood pressure, and extracellular, intracellular, and plasma volumes at the start of treatment (ST) (days 2–4), end of treatment (ET) (days 12–14), and follow-up (FU) (days 15–18).

RESULTS
Fourteen patients were included in the efficacy analysis. Mean (SD) baseline sodium excretion (150 [32] mmol/24-h) did not significantly change during treatment (change at ST: −7.0 mmol/24-h [95% CI −22.4, 8.4]; change at ET: 2.1 mmol/24-h [−28.8, 33.0]). Mean baseline 24-h systolic blood pressure was 128 (10) mmHg and significantly reduced at ST (−6.1 mmHg [−9.1, −3.1]; P &lt; 0.001) and ET (−7.2 mmHg [−10.0, −4.3]; P &lt; 0.001). Dapagliflozin did not significantly alter plasma volume or intracellular volume, while extracellular volume changed at ST (−0.7 L [−1.3, −0.1]; P = 0.02). As expected, 24-h urinary glucose excretion significantly increased during dapagliflozin treatment and reversed during FU.

CONCLUSIONS
During standardized sodium intake, dapagliflozin reduced blood pressure without clear changes in urinary sodium excretion, suggesting that factors other than natriuresis and volume changes may contribute to the blood pressure–lowering effects.
Penggunaan Metode Pembelajaran Eksperimen untuk Meningkatkan Hasil Belajar Fisika Materi Pengukuran Siswa
Authors: Susilo Agus 
Published: December 2020

Kurangnya penggunaan metode pembelajaran dalam proses pembelajaran membuat hasil belajar siswa dalam belajar menjadi rendah. Aspek kompetensi meliputi tiga ranah yaitu, pengetahuan, sikap dan keterampilan ketiga aspek tersebut harus terintegrasi dalam proses pembelajaran. Penelitian ini bertujuan untuk meningkatkan hasil belajar, kemampuan pengetahuan, dan keterampilan siswa melalui penerapan metode eksperimen. Penelitian ini merupakan penelitian tindakan kelas (PTK) pada kelas X SMK kompetensi keahlian multimedia, dengan materi pokok/kompetensi dasar molekul. Metode penelitian dalam penelitian ini adalah eksperimen/praktik pada pembelajaran fisika.Jenis penelitian adalah penelitian tindakan kelas yang bersifat kolaborasi antara peneliti dan guru.Data yang digunakan untuk mengetahui kemampuan awal siswa adalah nilai rata-rata raport pada saat siswa masuk ke SMK serta untuk mengetahui proses dan hasil pembelajaran dengan rata nilai test pada setiap siklus dengan menggunakan metode eksperimen/praktik. Hasil penelitian menunjukkan bahwa ada peningkatan hasil test tiap siklus. Dengan jumlah siswa sebanyak 32 orang sebelum pra siklus nilai rata-rata 6,03, siklus I nilai rata-rata 6,25, pada siklus ke II nilai rata-rata 7,58,. Berdasarkan analisa data tersebut dapat dilihat bahwa penerapan metode eksperimen/praktik dapat meningkatkan hasil belajar siswa.
Comparison of two asynchronous QCT methods
Authors: Petraikin A. V. , Smorchkova A. K. , Kudryavtsev N. D. , Sergunova K. A. , Artyukova Z. R. , Abuladze L. R. , Iassin L. R. , Petraikin F. A. , Lobanov M. N. , Nikolaev A. E. , Khoruzhaya A. N. , Semenov D. S. , Nisovstova L. A. , Vladzymyrskyy A. V. , Morozov S. P. 
Published: December 2020

Rationale. Quantitative CT (QCT) bone densitometry with asynchronous calibration not require a phantom during the scan procedure. Based on calibration data it converts X-ray density in HU to bone mineral density (BMD). Given the large number of CT studies performed on patients at risk of osteoporosis, there is a need for a hands-on method capable of assessing BMD in a short period of time without tailored software or protocols.Goal. To develop a method for QCT bone densitometry using an PHK (PHantom Kalium), to compare the volume BMD measurements with the QCT data with asynchronous calibration provided by software from a reputable developer.Methods. The studies were performed at 64-slice CT unit with body scanning parameters. The BMD was measured using two techniques: 1) QCT with asynchronous calibration using software from a reputable developer; 2) QCT using a PHK phantom (QCT-PHK). For convert the HU to BMD values, we scanned the PHK phantom and calculate correction factor. Phantom contains “vertebrae” filled with potassium hydrogen phosphate in different concentrations. In both methods, the BMD values measured for LI–II, and sometimes for ThXII, LIII.Results. The study enrolled 65 subjects (11 male and 54 female patients); median age 69.0 years. A comparison of the vertebrae BMD measured by QCT and QCT-PHK revealed a significant linear Pearson correlation r = 0.977 (p < 0.05). The Bland–Altman analysis demonstrated a lack of relationship between the difference in measurements and the average BMD and a systematic BMD; bias of +4.50 mg/ml in QCT vs. QCT-PHK. Differences in the division into groups osteoporosis / osteopenia / norm according to the ACR criteria for the two methods were not significant.Conclusion. The developed asynchronous QCT-PHK method measure BMD comparable to the widely used QCT with asynchronous calibration. This method can be used for opportunistic screening for osteoporosis.
RESEPSI SASTRA MAHASISWA TERHADAP PUISI ANTIKORUPSI DALAM ANTOLOGI PUISI MENOLAK KORUPSI 6
Authors: Wicaksono Andi 
Published: December 2020

Tujuan dari penulisan artikel ini adalah untuk mendeskripsikan dan menjelaskan tentang resepsi sastra mahasiswa terhadap puisi antikorupsi yang dimuat di dalam Antologi Puisi Menolak Korupsi 6: Membedah Korupsi Kepala Daerah. Prosedur penelitian yang digunakan untuk melihat aspek resepsi estetik ini adalah metode deskriptif kualitatif. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan resepsi sastra secara eksperimental. Berdasarkan analisis yang telah dilakukan diperoleh hasil bahwa resepsi sastra mahasiswa terhadap puisi antikorupsi yang dimuat di dalam buku antologi puisi tersebut secara garis besar sudah sesuai dengan maksud penulisan dan penerbitannya. Adapun tolok ukur kesesuaian resepsi estetis tersebut dilihat dari aspek pemahamannya, kelayakan karya yang dimuat sebagai puisi yang baik, sikap responden terhadap ide-ide yang disampaikan dalam puisi, penentuan sasaran pembacanya, serta peran antologi puisi dan gerakan sastrawan menolak korupsi terhadap pemberantasan korupsi.Kata Kunci: resepsi sastra, mahasiswa, puisi, antikorupsiAbstractThe purpose of this article is to describe and explain about the literary reception of students about anticorruption poems contained in Antologi Puisi Menolak Korupsi 6: Membedah Korupsi Kepala Daerah. The research procedure used to look at this aesthetic reception aspect is a qualitative descriptive method. The approach used in this study is an experimental reception approach. Based on the analysis that has been done, the results are obtained that the students' literary reception on anticorruption poems contained in the poetry anthology book is broadly following the purpose of their writing and publication. The aesthetical appropriateness benchmarks are seen from the aspect of understanding, the appropriateness of works published as good poetry, the respondent's attitude to the ideas expressed in poetry, the determination of the target audience, and the anthology role of poetry and the literary movement against corruption.Keywords: literary reception, students, poetry, anti-corruption
An overview of the Necessities, Challenges & Outcomes of Building Information Modeling (BIM) Framework used in Project Management
Authors: Shahid Iqbal  , Muhammad Saad  , Masab -Bin -Shahid  , Wajeeha Batool  
Published: December 2020

Building Information Modeling (BIM) is gaining attention worldwide due to its assistances during the entire building’s construction life cycle covering all phases of project from commencement to accomplishment. BIM integrates different disciplines by effective communication, analyzes the project systems for constructability, estimates the cost and time of projects at any time using quantity takeoffs. Notwithstanding that fact Pakistan like other developing countries is lagging in Building Information Modeling (BIM) adoption. To facilitate the adoption of Building Information Modeling (BIM) in the AEC industry, the purpose of this research study is to identify the important factors for BIM adoption among construction engineers of Pakistan to carry out the awareness.
It is found statistically that Building Information Modeling (BIM) capability is most important factors for the adoption of BIM among the construction engineers in Pakistan having the factors of motivation and management support which positively effect on BIM adoption in Pakistan. The trainings are very important to increase the BIM adoption in the industry.
“Não é uma fantasia, este sou eu”: Discussões sobre a representação e performance da masculinidade negra na série Sex Education (2019)
Authors: Souza da Cruz Andrey Gabriel , Baliscei João Paulo 
Published: December 2020

Resumo: Tendo como pauta as masculinidades, parece-nos prudente tratar de outros marcadores identitários, tais como raça e sexualidade, já que as performances masculinas são múltiplas e organizadas de modo hierárquico. O objetivo deste artigo é investigar a identidade do personagem Eric Effiong, um dos coadjuvantes da série Sex Education (2019). Trata-se de um homem-jovem-negro-gay que, por suas diferenças identitárias, apresenta uma masculinidade considerada dissidente da norma. Para isso, ancoramo-nos nos Estudos das Masculinidades - campo que tem se dedicado a perceber e analisar as maneiras assimétricas a partir das quais as masculinidades são instituídas – e nos Estudos da Cultura Visual – aporte teórico que investiga as imagens para além de seus aspectos compositivos. Para a organização deste texto, primeiro apresentamos nosso objeto de análise - a construção do personagem Eric. Depois, aprofundamo-nos nas concepções de masculinidades e na investigação visual crítica de três cenas da série. Adotamos o PROVOQUE como procedimentos de análise. Finalizamos vislumbrando os modos como personagens dissidentes, tais como Eric, podem desestabilizar e romper com formas recorrentes e estereotipadas nas representações de indivíduos masculinos, negros, gays e afeminados.Palavras-chave: Gênero, Cultura Visual, negritude. Resumen: Teniendo como tema las masculinidades, nos parece prudente tratar de otros marcadores de identidad, tales como raza y sexualidad, ya que las performances masculinas son múltiples y organizadas de manera jerárquica. El objetivo de este artículo es investigar la identidad del personaje Eric Effiong, uno de los secundarios de la serie Sex Education (2019). Se trata de un hombre-joven-negro-gay que, por sus diferencias de identidad, presenta una masculinidad considerada disidente de la norma. Para eso, nos anclamos en los Estudios de las Masculinidades - campo que se ha dedicado a percibir y analizar las maneras asimétricas desde las cuales las masculinidades son instituidas - y en los Estudios de la Cultura Visual - aporte teórico que investiga las imágenes para más de los aspectos que las componen. Para la organización de este texto, primero presentamos nuestro objeto de análisis - la construcción del personaje Eric. Luego, nos aprofundamos en las concepciones de masculinidades y en la investigación visual crítica de tres escenas de la serie. Adoptamos el PROVOQUE como procedimientos de análisis. Finalizamos vislumbrando los modos como personajes disidentes, tales como Eric, pueden desestabilizar y romper con maneras recurrentes y esteriotipadas en las representaciones de individuos masculinos, negros, gays y afeminados.Palabras clave: Género, Cultura Visual, negritud.
Антипсихотик нового поколения карипразин (Реагила) в лечении шизофрении: спектр клинической эффективности и безопасности
Authors: Ivanov S. V. , Smulevich A. B. , Voronova E. I. 
Published: December 2020

Цель: по данным научных публикаций представить анализ свойств новейшего антипсихотика третьего поколения карипразина, частичного агониста дофаминовых рецепторов с уникальным предпочтительным взаимодействием с D3- относительно D2-рецепторов.Материалы и метод: по ключевым словам «шизофрения», «негативные расстройства», «терапия», «карипразин» проведен поиск и анализ научных статей в базах данных MEDLINE, PubMed и в других библиографических источниках за период с 2000 по 2020 г.Заключение: обобщены данные преклинических и клинических исследований препарата с последовательным анализом параметров фармакодинамики, фармакокинетики, клинической эффективности, переносимости и безопасности на всех этапах терапии шизофрении, включая купирующую терапию обострений и длительную поддерживающую терапию с профилактикой рецидивов. Сформулированы предварительные рекомендации по применению карипразина в клинической практике с учетом особенностей фармакологических и клинических характеристик препарата.
Platelet Enzymes of Glutathione Metabolism in Patients with Late-Onset Schizophrenic Spectrum Disorders
Authors: Savushkina O. K. , Boksha I. S. , Tereshkina E. B. , Prokhorova T. A. , Sheshenin V. S. , Pochueva V. V. , Vorobyev E. A. , Burbaeva G. Sh. 
Published: December 2020

Background: basing on the hypothesis that oxidative stress participates in schizophrenia pathogenesis, the authors suggested that the activities of glutathione reductase (GR) and glutathione-S-transferase (GST), the enzymes metabolizing the central antioxidant glutathione, are altered in patients with schizophrenia spectrum disorders.Objective: determination of activity of platelet glutathione reductase (GR) and glutathione-S-transferase (GST) in patients with late-onset schizophrenic spectrum disorders (LOS - spectrum psychoses) and evaluation of their possible connection to clinical indicators.Patients and methods: 28 female in-patients aged 45–86 years with LOS-spectrum psychoses were examined: schizophrenia (n = 16), schizoaffective disorder (n = 6), chronic delusional disorder (n = 6). A control group of women of the same age range without mental and neurological diseases was recruited. Platelet GR and GST activities in patients were determined before and after the course of pharmacotherapy, and in the control group - only once.Results: assessment of the patients’ symptoms’ severity using PANSS, HAMD, and MMSE was carried out before and after the course of pharmacotherapy (at the 28th day of the therapy course). The efficacy of therapy was determined by the change in the PANSS and HAMD total score. While the GR activity did not differ significantly in patients and in the control group, GST activity was found substantially and significantly reduced in patients (before and after the course of therapy) compared with the control group, although GST activity in patients did not significantly change during their treatment. In both cases (GR and GST), three patients were observed among the patients with enzymatic activity exceeding > 1.5 times the medians in the group. After the course of treatment, the activity of enzymes decreased to a level within the range of control values or values for other patients.Conclusion: the results of a pilot study indicate the promise of determining the activity of GR and GST in a group of patients with LOS-spectrum endogenous psychoses to distinguish among them subgroups with glutathione metabolism abnormalities that correlate with clinical and pathopsychological features.
Сellular and Molecular Mechanisms of Proinflammatory Monocytes Participation in the Pathogenesis of Mental Disorders. Part 2
Authors: Vasilyeva E. F. , Brusov O. S. 
Published: December 2020

Introduction: at the end of the last century, the macrophage-T-lymphocyte theory of the development of mental disorders was formulated. It underlines the important role of monocytes/macrophages and cytokines produced by them in the pathogenesis of schizophrenia, bipolar affective disorder (BAD) and depression. The first part of our review is dedicated to the analysis of the mechanisms of cellular and molecular interactions of activated monocytes/macrophages synthesizing proinflammatory CD16 receptors with endothelial cells, platelets, and microglia cells in the pathogenesis of systemic immune inflammation, including CNS as a result of violation of the integrity of the blood-brain barrier (BBB), activate microglia and cause the development of neuroinflammation in patients.The aim of work: to analyze and summarize the results of the main scientific publications for the role of cell-molecular mechanisms of the monocyte-macrophage immunity link activation in the pathogenesis of schizophrenia, BAD and depression. Material and methods: keywords “proinflammatory monocytes, cytokines, chemokines, molecules of cell adhesion, microglia, neuroinflammation, mental disorders” were used to search for data published over the past 20 years in domestic and foreign studies in PubMed, eLIBRARY, Science direct and EMBASE.Conclusion: the present review is dedicated to the analysis of the latest research data concerning an increase in the number of active circulating monocytes/macrophages and an increased level of proinflammatory cytokines, chemokines and receptors for them produced by monocytes in patients with schizophrenia, BAD and depression, what allows to associate these disorders with systemic immune inflammation. The data reasearches on cellular and molecular mechanisms of proinflammatory monocytes/macrophages interaction with microglia cells that initiate neuroinflammation in the CNS and lead to destabilization of brain function and the development of psychotic disorders are presented. The association of high levels of proinflammatory cytokines with somatic comorbidity, including metabolic syndrome, diabetes, atherosclerosis and other systemic diseases is shown in patients with mental disorders.Findings: the presented review of the research data allows us to better understand the cellular and molecular aspects of activation of the monocyte-macrophage immunity link in the development of neuroinflammation and cognitive decline in the pathogenesis of mental disorders, as well as helps in the search for informative biomarkers of the positive treatment of these disorders and the new approaches in the treatment of patients, based on the complex use of psychotropic and anti-inflammatory drugs.
EFETIVIDADE DO ACESSO ELETRÔNICO À JUSTIÇA DIRETAMENTE PELO CIDADÃO EM TEMPOS DE PANDEMIA: atermação online
Authors: Ribeiro Leila Maria Tinoco Boechat , Souza Carlos Henrique Medeiros de 
Published: December 2020

O acesso à Justiça pela via eletrônica, mormente em meio à pandemia do Coronavírus, em que os órgãos jurisdicionais se encontram com suas atividades presenciais suspensas, torna-se ainda mais desafiador àqueles cidadãos que ainda não dispõem de meios tecnológicos e/ou o conhecimento técnico para sua utilização. Nesse contexto, em que os tribunais implementam a atermação online como uma das alternativas para facilitação de acesso à Justiça, por parte do cidadão, apresenta-se a seguinte questão problema: De que maneira a atermação online tem contribuído para a efetividade do direito de acesso à Justiça, diretamente pelo cidadão, nesse momento de excepcionalidade da COVID-19? Objetiva-se analisar a atermação online como meio de assegurar efetividade ao direito humano/fundamental de acesso à Justiça ao cidadão, de forma direta, pela via eletrônica, no contexto da COVID-19, numa abordagem interdisciplinar Direito e Novas Tecnologias da Informação e Comunicação, perpassando fundamentos teóricos sobre a temática e trazendo-se à baila entrevista com Analicia de Fátima Ribeiro Freitas, 65 anos, sobre sua experiência no ajuizamento de ação, via atermação online, para obtenção de benefício assistencial. Justifica-se o estudo por sua relevância acadêmica e social à medida que visa contribuir para a efetividade do direito humano/fundamental de acesso à Justiça do cidadão. A metodologia adotada é qualitativa, quanto ao problema; exploratória, quanto aos objetivos; e pesquisa bibliográfica e entrevista, quanto aos procedimentos técnicos. Espera-se contribuir para a efetividade do direito de acesso à Justiça do cidadão, pela via eletrônica, nos amplos termos em que consagrado no ordenamento pátrio e diplomas internacionais.
Palavras-chave: Acesso. Justiça. Cidadão. Via eletrônica. Coronavírus.
Model Pengembangan Pendidikan Pesantren Muhammadiyah Boarding School Jombang
Authors: Furqon  , Dr. Isa Anshori, M.SI  
Published: December 2020

This research aims to understand about the education developing model of MuhammadiyahBoarding School Jombang, factor endowments and a barrier, as well as the efforts of addressing and resolving the various obstacles.
This research uses qualitative methods with a phenomenology approach to the subject: caregivers, ustadz – ustadzah and director ofMuhammadiyah Boarding School Jombang. This research uses data collection techniques of observation, interview, and document. Whereas the data collected is analyzed through the stages of data reduction, data display and take conclusion. The results showed that the education developing model of Muhammadiyah Boarding School Jombang combines educational systemof formal education by using ekspositori strategies, inquiry, CTL,as well as evaluation system formative and summative. In this boarding schools utilizes information and communication technologies as a means of supporting education and quality of ustadz- ustadzahin accordance with the field of their education, barriers in these boarding schools is the lack of ustadz – ustadzah qualified and competent in their field, not the lack of adequate facilities and infrastructure, and lack of funding there are various attempts are made to overcome these obstacles include: improving the quality of human resources (ustadz – ustadzah), searching for ustadz – ustadzah that corresponds to the field of education, to improve the existing infrastructure as well as cooperation with communities and agencies for the provision of infrastructure and the provision of funds.
Enhancing students motivation in Learning English Language for non-philology students
Authors: (IJIE) International Journal on Integrated Education , Sobirova Robiyaxon Maxamatismoyilovna  
Published: December 2020

We all know that ensuring the quality of foreign language teaching of the younger generation, radically improving the system of training specialists fluent in foreign languages, the development of foreign languages ​​that meet international educational standards. Training is one of the goals of the ongoing educational reform in our country. In order to identify and identify opportunities for language teaching, the teacher's knowledge, creativity, ability to arouse students' love for their subject, to establish a cooperative relationship with the student requires modern requirements. The decision is aimed at further development of foreign language teaching, implementation of measures to improve the level and quality of training of highly qualified teachers of foreign languages ​​for secondary schools, vocational colleges and academic lyceums, higher education institutions in accordance with international standards. At the same time, it should be noted that each language studied has its own rules and secrets. In order to become a professional who meets international standards, the learner is required to ignore the most delicate layers of language.