bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Glycemic Status with Disease Severity in Guillain-Barré Syndrome
Authors: Hossain Mohammad Akter , Hasan Mashfiqul , Rahman Mohammad Atiqur , Baqui Murshed , Islam Mahmudul , Hakim Maliha 
Published: December 2020

Background: Guillain-Barré syndrome (GBS) is an acute autoimmune polyneuroradiculopathy characterized by flaccid paralysis which may lead to respiratory failure requiring intensive care.
Objective: The purpose of the present study was to explore the relationship between the fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) and disease severity of GBS patients who are not known to have DM.
Methodology: This cross-sectional study included adult GBS patients without having DM [age 35 (22-48) years, median (interqurtile range, IQR); 39 male 22 female] who were admitted to Neurology department, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from July 2018 to June 2019. Demographics, clinical data were noted and FPG, HbA1c were measured. Disease severity were assessed by the GBS disability scale ranging from 0 to 6 with increasing score reflecting increased disability.
Results: Patients with more severe GBS (disability score ≥4, unable to walk) had higher frequency of elevated FPG >5.5 mmol/L (61.2%; 30/49) in comparison to those with less severe GBS (disability score ≤3, able to walk; FPG >5.5 mmol/L in 16.7%, 2/12; p=0.006). But distribution of HbA1c category was not different across the groups (disability score ≥4 vs. ≤3: HbA1c <5.7: 40% vs. 58%; 5.7-6.4: 50% vs. 25%; >6.4: 10% vs. 17%; p=0.296). Participants with elevated FPG were elder [elevated vs. normal FPG: 40 (28-54) vs. 25 (19-43) years; median (IQR), p=0.012] and had higher CSF glucose (p=0.002) than those with normal FPG, but there was no difference in respct of gender, MRC sum score, requirement of assisted ventilation, CSF protein, GBS subtypes and duration of hospital stay (p=not significant for all).
Conclusions: Patients with severe GBS have higher frequency of elevated FPG but not HbA1c. An acute change in glucose metabolism may occur in GBS which needs further study.
Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 96-100
Prevalence of Extended Spectrum ß-Lactamase Producing Klebsiella Pneumoniae Isolates in A Tertiary Care Hospital in Bangladesh
Authors: Sonia Suraiya Jahan , Ahsan Tasnim , Ahmed Tafneen Farhana , Nazneen Shah Walia , Uddin Kazi Hafiz , Shamsuzzaman SM 
Published: December 2020

Background: Extended-spectrum β lactamases (ESBLs) continue to be a major challenge in clinical setups world over, conferring resistance to the expanded-spectrum cephalosporins.
Objectives: The aim of this study was to determine the prevalence of extended spectrum β-lactamase (ESBL) in strains of Klebsiella pneumoniae isolated from different clinical specimens in Dhaka Medical College Hospital, Dhaka, Bangladesh.
Methodology: This cross sectional study was carried out at the Department of Microbiology of Dhaka Medical College, Dhaka, Bangladesh from July 2016 to June 2017. Klebsiella pneumoniae were isolated from different clinical specimens from adult hospitalized patients. These isolates were screened for ESBL production according to Clinical and Laboratory Standards Institute (CLSI) guidelines. ESBL production was confirmed by the phenotypic confirmatory double disc synergy test (DDST).
Results: Among the 500 collected samples 75 Klebsiella pneumoniae were isolated. Among them, 68 isolates were selected for confirmatory tests of ESBL according to CLSI guidelines. Finally, 19 isolates were confirmed as ESBL producers by DDST (25.33%).
Conclusion: In the present study, a large number of isolates are found to be ESBL producers.
Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 101-104
Instagram y TikTok: apuesta segura en cualquier comunicación cultural
Authors: Robles Laura 
Published: December 2020

Las plataformas sociales y las tecnologías están cada vez más insertas en la vida del usuario y del público objetivo. En este sentido, las instituciones culturales deben estar al día para ofrecer a sus receptores lo que les gusta y captar su interés para obtener beneficios: reconocimiento de marca e incremento de ventas, entre otros aspectos. Redes sociales como Instagram y TikTok son las más afines y las que mayor nivel de interacción ofrecen debido a la gran variedad de herramientas disruptivas y originales que tienen, como vídeos en directo, creación de imágenes personalizadas, publicación de guías, etc. Para ello, es fundamental realizar una estrategia y estudio previo para lanzar cualquier contenido, hay que saber cómo acercarse a los públicos nuevos y de qué manera utiliza la tecnología actualmente. Las redes sociales nos ofrecen la posibilidad de estar conectados desde cualquier parte del mundo y visitar museos y monumentos desde nuestro sofá.
Otro aspecto fundamental en estos nuevos canales es la relación que hay entre el marketing de influencers y estas redes sociales, un nuevo canal desde el que obtener mayor alcance a través de un personaje público que pueda sentirse afín a la marca o institución.
Y como todo, nada de esto sirve, si a posteriori no se miden los resultados y se vuelcan en estadísticas. Toda acción debe ser medible para seguir generando nuevas estrategias y hacer pruebas. La cuestión es testear y conocer en profundidad qué necesita nuestro público y cómo se mueve digitalmente en su día a día.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN IPS SISWA KELAS V SD MATERI KERAJAAN DAN PENINGGALAN HINDU DI INDONESIA
Authors: Wicaksono Antonius Alam , Bariska Hanif Fikri 
Published: December 2020

Bertolak dari latar belakang tersebut rumusan masalahnya adalah : 1) Apakah penerapan model kooperatif tipe STAD dapat meningkatkan hasil belajar Pada Pembelajaran Kerajaan dan Peninggalan Hindu di Indonesia Mata Pelajaran Ilmu Penetahuan Sosial, 2) Bagaimana pengaruh penerapan model STAD dapat meningkatkan hasil belajar Pada Pembelajaran Kerajaan dan Peninggalan Hindu di Indonesia Mata Pelajaran Ilmu Pengetahuan Sosial. Untuk menjawab pertanyaan itu peneliti menggunakan metode Tes (pre test dan post test) dan metode observasi dalam pengumpulan data sebagai bukti atau fakta dalam penelitian ini. Hasil yang dalam penelitian “Penerapan Model Pembelajaran Kooperatif Tipe STAD Untuk meningkatkan Hasil Belajar Siswa Pada Mata Pelajaran Ilmu Pengetahuan Sosial Kelas V SDN Dinoyo I Malang Materi Kerajaan dan Peninggalan Hindu di Indonesia ”lebih meningkat. Hal ini terlihat dari nilai rata-rata siswa sebelum menggunakan model Pembelajaran KooperatifTipe STAD adalah 50 dan setelah menggunakan model Pembelajaran Kooperatif Tipe STAD nilai rata-rata siswa adalah 84,61. Sedangkan persentase peserta didik yang tertarik saat pembejaran tipe STAD sebesar 100%.
Influência da adição de ácido sórbico encapsulado em pão de forma para extensão da vida útil
Authors: Nogueira Rafael Ribeiro , Romantini Beatriz Cury , Matuzaki Letícia Hana , Ribeiro Eliana Paula , Matuda Tatiana Guinoza 
Published: December 2020

Pães de forma são amplamente comercializados e a sua distribuição está diretamente relacionada à sua vida útil. Sua conservação e segurança, na maioria dos casos, dependem da adição de conservante para evitar o desenvolvimento de bolores. O ácido sórbico e seus sais são amplamente utilizados em produtos de panificação, porém não podem ser adicionados diretamente na massa, pois inibem a ação da levedura durante a fermentação, em sua forma microencapsulada, será liberado após a fermentação, não comprometendo o volume dos pães e o tempo de processo. A influência da adição de ácido sórbico microencapsulado, em uma matriz de óleo de canola (50:50) (A) ou em núcleo envolto em óleo de palma (85:15) (B), nas concentrações 0,10 % e 0,05 % (base farinha), para aumento da vida útil de pão de forma foi avaliada em relação a textura, umidade, atividade de água e presença de bolores. Estes parâmetros foram usados para determinação do tempo de vida útil e estudo do mecanismo de envelhecimento do pão de forma, associado a perda de umidade e ao aumento da firmeza. Os melhores resultados foram obtidos para as concentrações de 0,05 % (base farinha) das duas amostras de ácido sórbico avaliadas e para 0,10 % do ácido sórbico microencapsulado em matriz de óleo de canola, obtido por atomização, apresentando uma vida útil de pelo menos 14 dias.
Projeto de cannabis terapêutica como extensão durante a pandemia: um relato de experiência
Authors: Carvalho Morgana Maria Sousa Gadêlha de , Cordeiro Annyelle Anastácio , Melo Beatriz Simone Monteiro de , Dias Brenno Anderson Santiago , Sousa Flávia Regina Galvão de , Moura Helene Soares , Oliveira Juany de Souto Matias , Figueiredo Lanna Lidia Monteiro , Deus Larissa Alves Assunção de , Amorim Luis Henrique Barbosa Alves , Silva Maria Isabel Araújo André da , Dias Maria Ismaela Lima de Barros , Silva Maria Luysa Almeida da , Rodrigues Matheus Andrade , Veríssimo Matheus Harllen Gonçalves , Silva Nathalia Fernandes da , Pereira Pauliny Anaiza de Almeida , Pereira Raquel Dantas , Santos Vivian Luana Andrade dos , Freitas Yasmim Christynne Oliveira Reis de 
Published: December 2020

Este trabalho, aborda a execução do projeto de extensão PEX CANNABIS da UEPB campus-VIII, apresentando temas por meio de ferramentas digitais, sobre a utilização da Cannabis medicinal e suas aplicações terapêuticas. Trata-se de um estudo descritivo, tipo relato de experiência protagonizado remotamente, sob cenário pandêmico, pelos alunos extensionistas do curso de Odontologia da Universidade Estadual da Paraíba (UEPB) no ano de 2020. O plano de atividades foi planejado a partir de reuniões consecutivas em plataformas como o Google Meet® e Zoom®, configurando o cronograma e a posterior execução de ações, como cine-debate, apresentação de seminários teóricos, realização de enquetes, postagens e publicações científicas, além de eventos realizados através de lives. Foi efetivada a publicação semanal de esquemas informativos sobre a Cannabis Terapêutica e sua aplicabilidade, obtendo um nível considerável de curtidas, comentários, envios, dentre outras formas de interação; cine-debate online, contatos nacionais e internacionais. Observou-se que, após a realização das atividades, houve um resultado satisfatório no que tange a interatividade por um vasto público e divulgação sobre os temas abordados, proporcionando um conhecimento cientifico e didático.
Sex Differences in Physical Activity and Its Association With Cardiac Death and All-Cause Mortality in Patients With Implantable Cardioverter-Defibrillators
Authors: Li Xiaoyao , Xue Xiaodi , Sun Xuerong , Zhao Shuang , Chen Keping , Hua Wei , Su Yangang , Yang Jiefu , Liang Zhaoguang , Xu Wei , Li Zeyi , Zhang Shu 
Published: December 2020

Objective: To clarify the impact of sex on physical activity (PA) levels among patients with implantable cardioverter-defibrillators/cardiac resynchronization therapy defibrillators (ICD/CRT-D) and its association with cardiac death and all-cause mortality.Methods: Overall, data of 820 patients with ICD/CRT-D from the SUMMIT registry were retrospectively analyzed. Baseline PA from 30 to 60 days after device implantation was measured using Biotronik accelerometer sensors. The primary and secondary endpoints were cardiac death and all-cause mortality, respectively.Results: Baseline PA levels were significantly higher in male patients than in female patients (11.40 ± 5.83% vs. 9.93 ± 5.49%, P = 0.001). Males had higher predictive PA cut-off values for cardiac death (11.16 vs. 7.15%) and all-cause mortality (11.33 vs. 7.17%). During the median follow-up time of 75.7 ± 29.1 months, patients with baseline PA&lt;cut-off values had higher cumulative incidence of cardiac death and all-cause mortality in both males and females. At a PA level between the cut-off values of males and females, males had a higher risk of cardiac death (hazard ratio = 4.952; 95%CI = 1.055-23.245, P = 0.043) and all-cause mortality (hazard ratio = 2.432; 95%CI = 1.095-5.402, P = 0.029).Conclusions: Males had higher predictive PA cut-off values for cardiac death and all-cause mortality in patients with ICD/CRT-D. Sex should be considered as an important contributing factor when deciding for PA targets.
Association Between Maternal Lifestyle and Risk of Metabolic Syndrome in Offspring—A Cross-Sectional Study From China
Authors: Li Yanhui , Yang Zhaogeng , Wang Xijie , Gao Di , Zou Zhiyong , Dong Bin , Ma Jun , Arnold Luke 
Published: December 2020

BackgroundThe prevalence of MS among children and adolescents continues to rise, which has become an escalating serious health issue worldwide. It had been reported that maternal current lifestyle had a strong independent correlation with offspring health. However, it is not clear whether comprehensive lifestyle of mother has an impact on the MS risk in offspring and the role of offspring’s lifestyle in it.Methods and ResultsWe included 4,837 mother-child pairs from a multi-centered cross-sectional study conducted in China. The information of maternal lifestyle was obtained by self-reported questionnaire, and metabolic syndrome (MS) in offspring was determined by anthropometric measurements and blood tests. Logistic regression models were employed to evaluate the association between maternal lifestyle and risk of MS in offspring. We found maternal healthy lifestyle was independently associated with lower risk of offspring MS, and the risk of MS in offspring decreased with the increased number of maternal ideal lifestyle factors. Although adolescents’ lifestyle did not fully explain the relationship between maternal lifestyle and risk of offspring MS, compared with those had less ideal lifestyle factors in both mothers and offspring, the risk of offspring MS was lower in those had more ideal lifestyle factors in both mothers and adolescents.ConclusionsHealthy lifestyle in mothers was associated with a lower risk of MS in offspring, which was independent of offspring’s lifestyle. These findings support mother-based lifestyle intervention could be an effective strategy to reduce the MS risk in adolescents.
Case Report: Orbital Myositis and Myasthenia Gravis as Symptoms of Immune Reconstitution Inflammatory Syndrome in a Patient With Human Immunodeficiency Virus Infection
Authors: Wang Yanli , Zhao Ning , Yang Jun , Wen Ying 
Published: December 2020

We present a case of a 37-year-old man with HIV infection who had been on antiretroviral therapy for one year. He was admitted to our hospital with red and swollen eyes, acute onset progressive exophthalmos, and intermittent diplopia endured for 7 days. His symptoms, exam, and imaging led to a diagnosis of immune reconstitution inflammatory syndrome associated orbital myositis. His symptoms improved considerably after glucocorticoid therapy. Following a reduction in the oral prednisone dose, he re-presented with left ptosis, which rapidly progressed to bilateral ptosis. Diagnostic testing led to the diagnosis of immune mediated myasthenia gravis. Treatment with pyridostigmine bromide, prednisone, and tacrolimus was initiated. One month later, the patient’s symptoms improved significantly. There was a probable association between his symptoms and autoimmune immune reconstitution inflammatory syndrome. This report highlights the importance of recognizing autoimmune disorders in human immunodeficiency virus-infected patients undergoing antiretroviral therapy. Orbital myositis and myasthenia gravis in human immunodeficiency virus-infected patients correlate closely with immunity status following a marked increase in CD4+ T cell counts.
Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility
Authors: Du Yanbo , Yan Lei , Sun Mei , Sheng Yan , Li Xiufang , Feng Zhenhua , Tang Rong 
Published: December 2020

Purpose: The aim of this study was to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer in women with endometriosis (EM).Methods: We performed a retrospective, database-search, cohort study and included data on EM patients who underwent frozen embryo transfer (FET) between January 1, 2009 and August 31, 2018. According to the protocols for FET cycle, the patients were divided into two groups: control group (n = 296) and hCG group (n = 355). Clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the two groups.Results: There was a significant increase in clinical pregnancy rate in the hCG group (57.7 vs. 49%, p = 0.027) compared with the control group. The live birth rate in the hCG group (45.6 vs. 38.5%, p = 0.080) was also elevated, but this difference was not statistically significant.Conclusion: hCG administration in HT regime for FET increases the pregnancy rate in women with EM.
Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission
Authors: Vrablicova Zuzana , Tomova Kristina , Tothova Lubomira , Babickova Janka , Gromova Barbora , Konecna Barbora , Liptak Robert , Hlavaty Tibor , Gardlik Roman 
Published: December 2020

Background:The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity in IBD patients in clinical remission.Materials and Methods:Plasma and serum were obtained from 72 patients with Crohn's disease and 28 patients with ulcerative colitis. Total cfDNA, nuclear DNA (ncDNA), mitochondrial DNA (mtDNA) and DNase activity were measured.Results:IBD patients showed higher levels of both ncDNA and mtDNA compared to healthy controls. Concentration of ncDNA was higher in males compared to females, including patients and healthy controls. However, unlike males higher amount of ncDNA was found in female IBD patients compared to healthy controls. DNase activity was significantly lower in male IBD patients compared with healthy controls. In addition, there was a negative correlation between DNase activity and ncDNA levels in male IBD patients.Conclusions:Herein we present increased amount of circulating ncDNA and mtDNA in IBD patients in clinical remission. Thus, unlike total cfDNA, circulating ncDNA and mtDNA might not represent the optimal biomarkers of disease activity. This is also the first report on sex difference in circulating ncDNA levels, possibly associated with lower DNase activity in males.
A Digital Innovation for the Personalized Management of Adherence: Analysis of Strengths, Weaknesses, Opportunities, and Threats
Authors: Hein Anna-Elisa , Vrijens Bernard , Hiligsmann Mickael 
Published: December 2020

Introduction: Personalized medicine and management of adherence are potential solutions for the suboptimal use of medicines. Digital medication management innovations currently under development combine both aspects. This research aims to investigate facilitators for and barriers to the translation of digital innovations for personalized medicine and adherence management into clinical practice from the policymaker and regulator perspective.Methods: A mixed-method study was used combining a scoping review to identify main interests, semi-structured interviews (n = 5) with representatives of European health policymaking and regulatory organizations, and a supplementary literature review to investigate key subthemes. The SWOT analysis was used for the qualitative analysis.Results: The literature reviews and the qualitative interviews suggested that digital solutions can facilitate the personalized management of medications and improve quality and safety, especially as the openness for digital health solutions is increasing. Digital solutions may, on the other hand, add complexity to the treatment, which can be perceived as a potential barrier for their uptake. As more multidisciplinary and participative structures are emerging, digital solutions can promote the implementation of new services. Nevertheless, change progresses slowly in the task-oriented structures of health systems. Integration of digital solutions depends on all stakeholders' willingness and abilities to co-create this change. Patients have different capabilities to self-manage their medical conditions and use digital solutions. Personalization of digital health solutions and integration in existing service structures are crucial to ensure equality among population segments. Developments in the digital infrastructure, although they are partly slow and not well-aligned, enable the implementation of innovations in clinical practice leading to further advances in data generation and usage for future innovations.Discussion: This study suggests that digital solutions have the potential to facilitate high-quality medication management and improve adherence to medications, enable new service structures, and are essential to drive further innovations in health care. Nevertheless, increasing the self-responsibility of patients can have undesirable effects on health outcomes, especially within vulnerable population segments. Digital health solutions can be an opportunity to optimize the use of medicines and thus their efficiency. Well-conceived development and implementation processes are needed to also realize improvements in equality and solidarity within health systems.
Correlative Magnetic Resonance Imaging and Histopathology in Small Ruminant Listeria Rhombencephalitis
Authors: Precht Christina , Vermathen Peter , Henke Diana , Staudacher Anne , Lauper Josiane , Seuberlich Torsten , Oevermann Anna , Schweizer-Gorgas Daniela 
Published: December 2020

Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to define magnetic resonance imaging (MRI) features of listeria rhombencephalitis in naturally infected small ruminants and correlate them with histopathology. Secondly, the purpose of this study was to compare the results with MRI findings reported in humans.Methods: Twenty small ruminants (13 sheep and 7 goats) with listeria rhombencephalitis were prospectively enrolled and underwent in vivo MRI of the brain, including T2-weighted, fluid attenuation inversion recovery, and T1-weighted sequences pre- and post-contrast administration and postmortem histopathology. In MRI, lesions were characterized by location, extent, border definition, signal intensity, and contrast enhancement. In histopathology, the location, cell type, severity, and chronicity of inflammatory infiltrates and signs of vascular damage were recorded. In addition, histopathologic slides were matched to MRIs, and histopathologic and MRI features were compared.Results: Asymmetric T2-hyperintense lesions in the brainstem were observed in all animals and corresponded to the location and pattern of inflammatory infiltrates in histopathology. Contrast enhancement in the brainstem was observed in 10 animals and was associated with vessel wall damage and perivascular fibrin accumulation in 8 of 10 animals. MRI underestimated the extension into rostral brain parts and the involvement of trigeminal ganglia and meninges.Conclusion: Asymmetric T2-hyperintense lesions in the brainstem with or without contrast enhancement can be established as criteria for the diagnosis of listeria rhombencephalitis in small ruminants. Brainstem lesions were similar to human listeria rhombencephalitis in terms of signal intensity and location. Different from humans, contrast enhancement was a rare finding, and abscessation was not observed.