bluuebunny/crossref_metadata_2025_split huggingface dataset:
4-7CORONARY ARTERY DISEASE ALTER ON NOVEL CLASSIFICATION LEFT VENTRICULAR GEMOMETRY IN HYPERTENSIVE PATIENTS IN HASAN SADIKIN GENERAL HOSPITAL BANDUNG
Authors: Tiksnadi B.B. , Martanto E. , Panggabean A. , Undarsa A.C. , Akbar M.R. 
Published: July 2020

Background:
Coronary artery disease (CAD) was known to cause an increase in left ventricular mass and changes in cardiac dimensions in hypertensive patients. There is a novel classification of left ventricular (LV) geometry.

Objective:
To evaluate the impact of CAD on LV geometry (LV dilatation, hypertrophy, and concetricity) in hypertensive patients at the Hasan Sadikin General Hospital Bandung.

Method:
Between September and December 2019, 115 consecutive patients underwent trans-thoracal echocardiography examination in Hasan Sadikin General Hospital Bandung, who had suffered from hypertension. Hypertension was defined as resting systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg or on antihypertensive therapy routinely. CAD was defined as the patients have a known history of CAD in the medical record. Patients were divided based on LV dilation (end-diastolic volume[EDV]/body surface area[BSA]>75 ml/m2), LV hypertrophy (LVM/BSA>115 and >95 g/m2 on men and women respectively), and concentricity (RWT>0.42;0.32–0.42;or<0.32).

Results:
One-hundred-ten patients were included after excluding patients with incomplete data. Sixty patients (54.55%) were females, mean age was 56.95±11.54 years old. Forty patients was diagnosed CAD (36.36%), 70 patients non-CAD (63.63%). Dilation LV was found in 23 patients (20.9%); CAD vs non-CAD (15/40 (37,5%) vs 8/70 (11,8%)); p = 0,001. Hypertrophic LV was found in 70 patients (63.6%); CAD vs non-CAD (32/40 (80%) vs 38/70 (54.3%)); p = 0,008. Concentricity RWT > 0,42 (60%), RWT 0,32–0,42 (31.8%), RWT < 0,32 (8.2%). In CAD vs non-CAD (26/7/7 vs 40/28/2); p = 0,04.

Conclusion:
In hypertensive patients, CAD group has significant difference in LV dilatation, hypertrophy, and concentricity compared to it counterparts. Based on this novel classification, CAD in hypertensive patients might have an impact on its prognosis.
4-9FEATURES OF HOMOCYSTEINE LEVEL AND A POTENTIAL WAY OF IT'S CORRECTION IN HYPERTENSIVE PATIENTS
Authors: Vamsi Varahabhatla , Cherukuri Raja , Tekula Tejashwini , Ratnam Itham Venkat , Viktor Buriak , Vadym Vizir 
Published: July 2020

Background:
Arterial hypertension (AH) is one of the most wide-spread cardiovascular pathology all over the world. Initiation and progression of AH are linked to many potentially modified metabolic factors, for example-hyperhomocysteinemia. Despite the fact that diagnostics, treatment and prevention of AH is evident, key risk factors correction are still concealed at present.

Aim:
To study the features of serum HH in hypertensive patients and optimize treatment strategy.

Methods:
According to the aim of our investigation, we examined 74 high cardiovascular risk level hypertensive patients (before and after 12-weeks of atorvastatin 20 mg per day oral administration based on their standard hypotensive treatment) and 68 healthy volunteers (equivalent with group of observation in age and gender representation) with fasting homocysteine plasma level via ELISA. The statistically significance was considered at P < 0,05.

Results:
It's set that AH is associated with fasting homocysteine plasma concentration 2,22 times more (P < 0,01) opposite to healthy subjects, that was according to mild level of hyperhomocysteinemia. Besides, it was found that additive 12-weeks treatment with atorvastatin (based on specific antihypertensive approaches) leads to clinically significant reduction of homocysteine plasma level by 28,78% (P < 0,05) in the hypertensive patients.

Conclusions:
HH is stationed as a key metabolic risk factor in way of arterial hypertension's formation and progression over the high cardiovascular risk population. At the same time, specific hypolipidemic and antiatherosclerotic treatment based on regular atorvastatin administration can be counted as an effective way of reducing elevated plasma homocysteine level and shows alternative pleiotropic effect of statins in AH patients.
Open Reduction Internal Fixation of Femoral Neck Fracture—Anterior Approach
Authors: Keshet Doron , Bernstein Mitchell 
Published: July 2020

Summary:
Femoral neck fractures are frequently treated with open reduction and internal fixation to achieve anatomical reduction. This video demonstrates open reduction internal fixation of a femoral neck fracture in a 59-year-old man, performed through an anterior approach. This approach provides safe and effective access to the femoral neck, including the subcapital and basicervical regions, with excellent direct visualization of the fracture site.
Minimally Invasive Plate Osteosynthesis Posterior Approach to Distal Humeral Shaft Fractures—A Surgical Technique
Authors: Krupko Thomas , Mayer Ryan , Scott Alesha , Aneja Arun , Moghadamian Eric 
Published: July 2020

Summary:
Comminuted extraarticular metaphyseal and diaphyseal fractures of the distal humerus frequently require operative fixation through a posterior approach. Most of the previously described approaches to the posterior humerus are dependent on large and extensile approaches. This video demonstrates open reduction and internal fixation of a comminuted metaphyseal distal humerus fracture through a minimally invasive posterior approach.
Prone Posteromedial Approach for Posterior Column Tibial Plateau Fractures
Authors: Foster Brock , Rodriguez-Buitrago Andres , Obremskey William T. 
Published: July 2020

Summary:
Tibial plateau fractures can involve fracture planes that require reduction and stabilization from a posterior approach. This includes posteromedial, posterolateral, and posterior column shear-type injuries. This video outlines the prone posteromedial approach to the tibial plateau for posterior column fracture exposure, reduction, and fixation.
A Rare Case of Invasive Gastric Mucormycosis in a Patient With Diffuse Large B Cell Lymphoma
Authors: Spiewak Ted Andrew , Eskandari Armen , Gui Dorina , Cogdill Asha Gupta 
Published: July 2020

Abstract
Mucormycosis is a rare but life-threatening opportunistic fungal infection, associated with high mortality in immunocompromised individuals. Gastrointestinal mucormycosis is uncommon compared with more frequently seen rhinocerebral and pulmonary forms. We report a case of invasive gastric mucormycosis in an 88-year-old man with diffuse large B-cell lymphoma, who presented with complaints of fever, coffee-ground emesis, and abdominal pain. On admission, he was hemodynamically unstable, severely malnourished, and somnolent. Abdominal tenderness was present in addition to neutropenia and severe anemia, requiring numerous transfusions. Endoscopy was performed showing multiple necrotic ulcers within the stomach. Histopathology revealed tissue-invasive mucormycosis. This patient was too ill for treatment and was discharged with hospice. Cases of invasive mucormycosis associated with hematological malignancy have been on the rise. Gastrointestinal infection is uncommon, which typically presents nonspecifically and can lead to devastating complications. Although this patient was too ill to undergo antifungal therapy and aggressive surgical debridement, early recognition, especially in high-risk patients, is imperative for improving overall prognosis.
Big Data in Transplantation Practice—the Devil Is in the Detail—Fontan-associated Liver Disease
Authors: Kim Michelle H. , Nguyen Ailene , Lo Mary , Kumar Subramanyan Ram , Bucuvalas John , Glynn Earl F. , Hoffman Mark A. , Fischer Ryan , Emamaullee Juliet 
Published: July 2020

Background.
As a result of the Fontan procedure, the prognosis of congenital single-ventricle heart disease has improved, with many affected children surviving into adulthood. However, the unanticipated consequences of chronic exposure to Fontan hemodynamics have revealed a new set of secondary noncardiac complications. Fontan-associated liver disease (FALD) is characterized by progressive hepatic fibrosis in nearly all patients post-Fontan, with the potential to develop cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. A lack of data regarding FALD-related prognosis makes consideration of indications for and timing of heart alone versus combined heart-liver transplantation challenging.

Methods.
A multidisciplinary group within the American Society for Transplantation analyzed several administrative datasets to study the epidemiology of FALD.

Results.
This approach presented several obstacles, and efforts to characterize FALD were limited by a lack of Fontan- and FALD-specific diagnostic codes and an inability to follow individual patients through multiple health systems. Several ongoing Fontan registries were also reviewed but these do not adequately capture FALD-related variables. Such barriers highlight the need for large-scale data collection in patients post-Fontan to better understand and care for this complex population.

Conclusions.
This study emphasizes the challenges of studying emerging transplant-related diagnoses in existing datasets and the need for mechanisms to adapt registries to appropriately identify patients with rare or emerging conditions.
Liver Transplantation of HCV-viremic Donors Into HCV-negative Recipients in the United States: Increasing Frequency With Profound Geographic Variation
Authors: Cotter Thomas G. , Aronsohn Andrew , Reddy K. Gautham , Charlton Michael 
Published: July 2020

Background.
Direct-acting antiviral therapy made possible the novel practice of utilizing hepatitis C virus (HCV)-viremic (HCV RNA-positive) donors into HCV-negative recipients in the United States. Although initial reports of outcomes have been satisfactory, higher-quality longer-term outcomes remain to be elucidated.

Methods.
National data were examined from the Organ Procurement and Transplantation Network on adult patients in the United States who underwent a primary, single organ, deceased donor liver transplant from January 1, 2016 to March 31, 2020. Outcomes of HCV-negative recipients (R−) who received an allograft from donors who were HCV RNA-positive (D HCV+) donors were compared with HCV RNA-negative (D HCV−) donors.

Results.
There has been a 35-fold increase in D HCV+/R− liver transplants over the past 4 y in the United States, from 8 in 2016 to 280 in 2019. There was an almost 6-fold difference in this practice among UNOS geographic regions. Graft survival following D HCV+/R− liver transplantation was excellent, with 1-y rates being 91% and 90% and 2-y rates being 88.5% and 87% for D HCV+/R− and D HCV−/R−, respectively (P = 0.672). In multivariate analysis, adjusting for other donor and recipient attributes, D HCV+/R− was not associated with patient or graft survival.

Conclusions.
The practice of D HCV+/R− continues to increase without discernible impact on medium-term outcomes. Notable geographic variation exists, suggesting inconsistent perceptions about the impact of D HCV+/R− transplantation on outcomes. These results strengthen the perceived safety in utilizing HCV-viremic donor organs as a donor pool expansion strategy, not only in the United States, but also worldwide.
The Prolyl Hydroxylase Inhibitor Dimethyl Oxalyl Glycine Decreases Early Gastrointestinal GVHD in Experimental Allogeneic Hematopoietic Cell Transplantation
Authors: Palaniyandi Senthilnathan , Kumari Reena , Venniyil Radhakrishnan Sabarinath , Strattan Ethan , Hakim Natalya , Munker Reinhold , Kesler Melissa V. , Hildebrandt Gerhard C. 
Published: July 2020

Background.
Prolyl hydroxylase inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1 alpha and affect signaling cascades of inflammation and cell death. Their beneficial use in experimental models of ulcerative colitis and lung allograft rejection led us to test the effect of the PHI dimethyl oxalyl glycine (DMOG) in the pathophysiology of graft versus host disease (GVHD).

Methods.
Acute GVHD was induced in lethally irradiated BALB/c mice. DMOG was administered intraperitoneally on alternate days for the first 2-weeks posttransplant, and then twice a week till day +50, while controls received vehicle only. Animals were monitored for clinical GVHD and analyzed at day +7 and at day +50.

Results.
DMOG treatment of allogeneic recipients improved survival by day +50, which was associated with decreased early gut injury and serum tumor necrosis factor-α compared with allogeneic controls. DMOG treatment of allogeneic recipients resulted in increased hypoxia-inducible factor-1 alpha expression and reduced apoptosis in the terminal ileum via Fas-associated protein with death domain protein repression along with decreased T-cell infiltration. Reduced pathology in colon after DMOG treatment associates with intestinal epithelium integrity and reduced damage caused by diminished recruitment of neutrophils.

Conclusions.
Taken together, we show protective effects of DMOG on early gut GVHD and improved survival in a model of allogeneic hematopoietic cell transplantation, providing the rationale for further evaluation of PHIs, in the prevention and treatment of acute GVHD.
Heat inactivating and reusing of virus-contaminated disposable medical mask
Authors: Song Wuhui , Pan Bin , Kan Haidong , Xu Yanyi , Yi Zhigang 
Published: July 2020

AbstractAs the prevalence of COVID-19 in all the area of China and continuous spread to many other countries, it is in urgent need of medical mask for community people. We have reported a simple method to inactivate artificially influenza virus-contaminated medical mask without affecting the filterability of mask by heating with hair dryer for 30min. In this study, we extended our studies to optimize our protocols and evaluate the filterability of mask after several-rounds of heat treatment. We found that baking at 70°C for 30min almost completely inactivated virus as hair dryer treatment for 30min described before. One-round of heat treatment with hair dryer for 30min or baking at 70°C for 30min did not affect filterability of mask whilst two-rounds of treatment slightly but significantly reduced filterability of mask. Thus, heating with hair dryer for 30min or baking at 70°C for 30min can inactive contaminated medical mask and the treated mask can be reused at least once.
Computational fluid dynamic (CFD), air flow-droplet dispersion, and indoor CO2 analysis for healthy public space configuration to comply with COVID 19 protocol
Authors: Adwibowo Andrio 
Published: July 2020

AbstractThe droplet has a limited travel distance. Nonetheless, especially in the indoor public space the air flow can propagate the droplet to travel long distance. Based on this situation, this paper aims to study the relationships of seat configuration-social distance-air flow-droplet dispersions. The analysis was based on the computational fluid dynamic (CFD) using lattice-Boltzmann model (LBM). The result confirms that by modifying public space configuration in this case by providing more space and increasing seating distance can reduce the vulnerability towards droplet dispersions. Whereas, providing shield including adding protection is far more effective in avoiding dispersions. The public space reconfiguration including increasing seat distance and reducing seating capacity also has an effect in reducing the indoor CO2. Capacity reduction from full capacity to 30% can decrease the CO2 from 5722 to 2144 ppm.
Global Assessment of the Relationship between Government Response Measures and COVID-19 Deaths
Authors: Hale Thomas , Hale Andrew J. , Kira Beatriz , Petherick Anna , Phillips Toby , Sridhar Devi , Thompson Robin N. , Webster Samuel , Angrist Noam 
Published: July 2020

AbstractObjectiveTo provide an early global assessment of the impact of government stringency measures on the rate of growth in deaths from COVID-19. We hypothesized that the overall stringency of a government’s interventions and the speed of implementation would affect the growth and level of deaths related to COVID-19 in that country.DesignObservational study based on an original database of global governmental responses to the COVID-19 pandemic. Daily data was collected on a range of containment and closure policies for 170 countries from January 1, 2020 until May 27, 2020 by a team of researchers at Oxford University, UK. These data were combined into an aggregate stringency index (SI) score for each country on each day (range: 0-100). Regression was used to show correlations between the speed and strength of government stringency and deaths related to COVID-19 with a number of controls for time and country-specific demographic, health system, and economic characteristics.InterventionsNine non-pharmaceutical interventions such as school and work closures, restrictions on international and domestic travel, public gathering bans, public information campaigns, as well as testing and contact tracing policies.Main outcomes measuresThe primary outcome was deaths related to COVID-19, measured both in terms of maximum daily deaths and growth rate of daily deaths.ResultsFor each day of delay to reach an SI 40, the average daily growth rate in deaths was 0.087 percentage points higher (0.056 to 0.118, P<0.001). In turn, each additional point on the SI was associated with a 0.080 percentage point lower average daily growth rate (−0.121 to −0.039, P<.001). These daily differences in growth rates lead to large cumulative differences in total deaths. For example, a week delay in enacting policy measures to SI 40 would lead to 1.7 times as many deaths overall.ConclusionsA lower degree of government stringency and slower response times were associated with more deaths from COVID-19. These findings highlight the importance of non-pharmaceutical responses to COVID-19 as more robust testing, treatment, and vaccination measures are developed.
Global pattern of COVID-19 research
Authors: Zhu Xunzhi , Jin Qi , Jiang Xiyi , Dan Yuanyuan , Zhang Aimin , Qiu Guangming , Lou Jianlin , Yu Hualong 
Published: July 2020

AbstractSince the COVID-19 outbreak began, a large number of studies have been conducted in a short period. However, it is unclear whether countries involved in this crisis have made adequate efforts and allocated resources to cutting-edge SARS-CoV-2 research. We analyzed the dynamics of and professional fields represented by papers about this novel coronavirus published before June 15, 2020. High-infection countries produced more scientific output than low-infection countries, and high-income and upper-middle-income countries were the main contributors. However, the research areas overlapped substantially, indicating a waste of resources. Our findings also suggest that international cooperation among countries is still relatively lacking, and all countries should make better use of their strengths to face the epidemic jointly.
Copper nanoparticles prompt the activity of estuarine denitrifying bacterial communities at relevant environmental concentrations
Authors: Costa Joana , Sousa António G.G. , Carneiro Ana Carolina , Mucha Ana Paula , Almeida C. Marisa R. , Magalhães Catarina , Baptista Mafalda S. 
Published: July 2020

AbstractEffects of metallic nanoparticles (NPs) to the estuarine biota have mostly been shown for concentrations higher than those actually measured or predicted in these environments. To address this gap, a range of concentrations expected to occur in estuarine environments (from 0.01 to 1 μg g-1) was employed in microcosms studies to assess the impact of Cu NPs in the denitrification pathway. That was achieved by quantifying gene expression and the potential denitrification rate in estuarine sediments exposed to Cu NPs for up to six days. Expression of nitrite (nirS) and nitrous oxide (nosZ) reductase genes was enhanced in a timewise manner. For the highest Cu NPs (1 μg g-1) an increase in gene expression could be seen immediately after 1 h of exposure, and continuing to be enhanced up until 7 h of exposure. For the lowest Cu NPs (0.01 μg g-1) an increase in gene expression could only be seen after 4 h or 7 h of exposure; however it continued to rise up until 24 h of exposure. In any case, after 48 h the expression levels were no longer different from the non-exposed control. Concomitantly to increased gene expression the potential denitrification rate was increased by 30 %. Our results suggest that deposition and adsorption of Cu NPs to estuarine sediments promotes the immediate and transient expression of key genes of the denitrification pathway. The long term impact of continuous inputs of Cu NPs into estuaries deserves renewed analysis to account for their effects, not just on the biota, but especially on ecosystems services.Environmental significanceInteractions of metallic nanoparticles with microbial communities of estuarine sediments are poorly characterized and its impact towards ecosystem services even less. By assessing the effect of copper nanoparticles on the expression of key genes of the denitrification pathway, an essential step for nitrogen (N) removal, we were able to show that denitrifying communities are immediately activated after exposure, increasing the denitrification rates in estuaries. The importance of denitrification lies in its release of dinitrogen (N2) to the atmosphere but also in the emissions of N2O (a potent greenhouse gas). The results obtained in this study gather data that contribute information on the denitrification dynamics in estuaries, invaluable for a timely response to the expected upcoming changes in coastal areas.Table of contentsIn estuaries the deposition upon the sediments of copper nanoparticles can contribute to change metal availability and promote the activity of denitrifying bacteria
Cadmium interference with iron sensing reveals transcriptional programs sensitive and insensitive to reactive oxygen species
Authors: McInturf Samuel A. , Khan Mather A. , Gokul Arun , Castro-Guerrero Norma A. , Hoehner Ricarda , Li Jiamei , Margault Henri , Kunz Hans Henning , Goggin Fiona L. , Keyster Marshall , Nechushtai Rachel , Mittler Ron , Mendoza-Cózatl David G. 
Published: July 2020

AbstractIron (Fe) is an essential micronutrient whose uptake is tightly regulated to prevent either deficiency or oxidative stress. Cadmium (Cd) is a non-essential heavy metal that induces both Fe-deficiency and oxidative stress; however, the mechanisms underlying these Cd-induced responses are still elusive. Here we explored Cd-induced Fe-associated responses in wildtypeArabidopsisandopt3-2, a mutant that over-accumulates Fe. Gene expression profiling revealed a large overlap between transcripts induced by Fe-deficiency and Cd exposure in wildtype plants and theopt3mutant. Interestingly, vascular-localized Fe-responsive genes were found to be highly induced by Cd even in the presence of high Fe and H2O2levels, suggesting that Cd impairs Fe sensing. It was recently shown that Fe-S cluster-containing proteins AtNEET, play a role in Fe sensing. Our data shows that Cd negatively impacts both the stability and Fe-S transfer activity of AtNEET. Altogether, our data indicate that Fe-deficiency responses are governed by multiple inputs and that a hierarchical regulation of Fe-deficiency responses prevents the induction of specific gene networks when Fe and H2O2levels are high. Other Cd/Fe-responsive genes however, are insensitive to this negative feedback regulation suggesting that their induction is the result of an impaired Fe sensing as opposed to the traditional view of Cd/Fe uptake competition at the root level.HighlightCadmium induces an iron-deficiency response often explained by root uptake competition; here we show that Cd also impairs Fe sensing in leaves, even when Fe is in sufficient quantities.