bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytological Grading of Chronic Lymphocytic Thyroiditis and Correlation with Thyroid Profile
Authors: Sajjan Netra M , Vani B R , V Srinivasamurthy , Vijayakumari V 
Published: December 2020

Background: Chronic lymphocytic thyroiditis is a thyroid specific autoimmune disease often seen in middle aged women, although rarely do occur in men, children1. This disease is characterized by antibody directed against thyroid peroxidase, called antimicrosomal antibody. The present study was undertaken to evaluate the various cytological features occurring in HT and to correlate with clinical and serological findings.
Methods: The study was conducted in department of Pathology from May 2017 to August 2017. The cases diagnosed as HT by FNAC were taken up for the study. Cytomorphologic features were reviewed microscopically and graded as per Bhatia et al.
Result: Fifty cases were diagnosed as lymphocytic thyroiditis. Age of the patient ranged from 7-56 years. Clinically 41 of 50 cases (82%) presented with diffuse thyroid enlargement. In our study we had 31 cases (62 %) of grade 2 thyroiditis, 15 and 4 cases each of grade 1 and grade 3 respectively. We observed increased TSH values in 100% of G3 thyroiditis and 64.5% of G2 thyroiditis. None of the Grade 1 thyroiditis had increased TSH levels. The statistical correlation between grades of thyroiditis with T3, T4 and TSH levels was found to be significant with p values < 0.05.
Conclusion: FNAC is simple cost effective and quick method for diagnosing HT. Also combined evaluation of HT with clinical findings and thyroid profile promotes more accurate diagnosis and early institution of therapy and follow up. FNAC is also necessary to rule out malignant lesions like lymphoma and papillary carcinoma at preliminary cytological level.
Challenges and considerations of applying nature-based solutions in low- and middle-income countries in Southeast and East Asia
Authors: Lechner Alex M. , Gomes Rachel L. , Rodrigues Lucelia , Ashfold Matthew J. , Selvam Sivathass Bannir , Wong Ee Phin , Raymond Christopher M. , Zieritz Alexandra , Sing Kong Wah , Moug Peter , Billa Lawal , Sagala Saut , Cheshmehzangi Ali , Lourdes Karen , Azhar Badrul , Sanusi Ruzana , Ives Christopher D. , Tang Yu-Ting , Tan David T. , Chan Faith Ka Shun , Nath Tapan Kumar , Sabarudin Nur Aliya Binti , Metcalfe Sarah E. , Gulsrud Natalie M. , Schuerch Mark , Campos-Arceiz Ahimsa , Macklin Mark G. , Gibbins Chris 
Published: December 2020

AbstractLow- and middle-income countries in Southeast and East Asia face a range of challenges related to the rapid pace of urbanisation in the region, the scale of pollution, climate change, loss of ecosystem services and associated difficulties for ecological restoration. Possible pathways towards a more sustainable future lie in the applications of nature-based solutions (NBS). However, there is relatively little literature on the application of NBS in the region, particularly Southeast Asia. In this paper we address this gap by assessing the socio-ecological challenges to the application of NBS in the region – one of the most globally biodiverse. We first provide an overview and background on NBS and its underpinnings in biodiversity and ecosystem services. We then present a typology describing five unique challenges for the application of NBS in the region: (1) Characteristics of urbanisation; (2) Biophysical environmental and climatic context; (3) Environmental risks and challenges for restoration; (4) Human nature relationships and conflicts; and (5) Policy and governance context. Exploiting the opportunities through South-South and North-South collaboration to address the challenges of NBS in Southeast and East Asia needs to be a priority for government, planners and academics.
Natural organic matter and sulphate elimination from rainwater with nanofiltration technology and process optimisation using response surface methodology
Authors: Köse-Mutlu Börte 
Published: December 2020

Abstract
In the current study, the effect of operating conditions including membrane characteristics and applied pressure on natural organic matter and sulphate removal of nanofiltration (NF) membranes for drinking water production was investigated. Water stress has been increasing all over the world due to population growth, climate change, and pollution; rainwater management stands out as one of the key solutions to this problem. Nanofiltration to treat rainwater stored in a cistern was studied. The objectives were sufficient treatment performance to overcome the taste problem and lower energy consumption. In this regard, three commercial nanofiltration membranes (NP010, NP030, and NF90) were used for the experiments carried out at 6–12 bar operating pressure regarding the response surface methodology. The correlation among the results of experiments and the model parameters were also calculated for all steps. According to the results, the effect of membrane characteristics was more abundant than the effect of the operating pressure. Finally, over 99% of natural organic matter and sulphate were eliminated in the optimum conditions. The results showed that it is possible to obtain treated rainwater with desired qualities, in a non-continuous NF plant operated at the pressure of 6 bar to reuse the rainwater and achieve water sustainability.
Hospitalidade no Buraco da Catita: Música e Comensalidade como opção de lazer em Natal/RN, Brasil
Authors: De Andrade Oliveira Cristiane Kateline , Melo da Cunha Silvânia , Almeida Gomes Dantas Amanda , Cavalcante Maria Bernadete , Moreira Sueli Aparecida 
Published: December 2020

O presente estudo tem como objetivo caracterizar a hospitalidade do Bar e Espaço Cultural Buraco da Catita enquanto local de lazer e entretenimento através da comensalidade e musicalidade oferecidos, tendo em vista o crescente interesse dos turistas de vivenciar boas experiências conhecendo a cultura local através da gastronomia, música e do ambiente em que se encontram. Foram obtidos depoimentos dos proprietários e dos usuários em relação ao Bar Buraco da Catita; perfil dos usuários do bar, atratividade comensal e hospitalidade. As informações foram obtidas através de depoimentos e enquete, com auxílio de formulário semiestruturado contendo 09 perguntas, aplicado com 32 usuários do Buraco da Catita. Os resultados obtidos evidenciaram que o local pesquisado possui grande potencial turístico, pois alia 03 importantes aspectos, a gastronomia, a música e a edificação histórica. A gastronomia é o principal atrativo do lugar, em seguida encontra-se a música. O complexo música e comensalidade retratam a boa hospitalidade. Melhorias na qualidade em promover o lugar, sem que este perca sua essência, podem fomentar ainda mais o turismo e disseminar a cultura local.
Palavras-chave: Turismo Cultural. Comensalidade. Hospitalidade. Buraco da Catita. Ribeira.
Creative Economy, Cinema and Tourism: a study about the movie "Os Xeretas” in the city of Castro/ Paraná – Brazil
Authors: Gonçalves Alencar Débora , Lima dos Santos Marina , Guissoni Rodrigo 
Published: December 2020

Os setores que correspondem às indústrias criativas, como o audiovisual, contribuem para as atividades turísticas. Este artigo apresenta uma relação direta entre esses setores por meio da imagem, da comunicação com o mercado, para estabelecer através da criatividade as relações entre o cinema (como a produção cinematográfica) e o cenário (como o destino turístico), além de fornecer novos recursos para a localidade, servir como exemplo ou modelo a ser seguido por outros destinos-cenário. Este artigo tem uma abordagem qualitativa e descritiva. Para entender o desempenho entre turismo e cinema, cujos elementos atribuem novos aspectos econômicos, sociais e culturais a um local após a produção do filme, esta pesquisa apresenta um estudo de caso do filme "Os Xeretas" (2001) gravado na cidade de Castro, estado de São Paulo. do Paraná - Brasil. Como resultado, houve a identificação de oportunidades para a cidade, como o incentivo ao desenvolvimento local, por meio do envolvimento entre pessoas, produtos e ambientes criativos entendidos como aspectos favoráveis à promoção do turismo.
Palavras-chave: Turismo. Cinema. Indústria Criativa. Desenvolvimento Local. Paraná - Brasil.
Silybin B and Cianidanol Inhibit Mpro and Spike Protein of SARS-CoV-2: Evidence from in silico Molecular Docking Studies
Authors: Srivastava Rashi , Tripathi Shubham , Unni Sreepoorna , Hussain Arif , Haque Shafiul , Dasgupta Nandita , Singh Vineeta , Mishra Bhartendu N. 
Published: December 2020

Background:
The main proteases (Mpro) and Spike Proteins (SP) of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) play a major role in viral infection development by producing several
non-structural proteins (nsPs) and penetrating the host cells, respectively. In this study, the potential of in silico
molecular docking-based drug repositioning approach was exploited for identifying the inhibitors of Mpro and
SP of SARS-CoV-2.

Methods:
A total of 196 compounds, including various US-FDA-approved drugs, vitamins, and their analogs,
were docked with Mpro (PDB IDs: 6YB7 and 6Y84), and the top six ligands were further tested for ADME
properties, followed by docking with SP (PDB IDs: 6LXT and 6W41).

Results:
Out of 196 compounds, binding energy (DE) of Silybin B (6YB7: DE: -11.20 kcal/mol; 6Y84: DE: -
10.18 kcal/mol; 6LXT: DE: -10.47 kcal/mol; 6W41: DE: -10.96 kcal/mol) and Cianidanol (6YB7: DE: -8.85
kcal/mol; 6LXT: DE: -9.36 kcal/mol; 6Y84: DE: -10.02 kcal/mol; 6W41: DE: -9.52 kcal/mol) demonstrated
better binding and ADME properties compared with the currently endeavored drugs like Hydroxychloroquine
and Lopinavir. Additionally, Elliptinone, Diospyirin, SCHEMBL94263, and Fiboflavin have shown encouraging
results. Fiboflavin, an immunity booster, was found to inhibit both the Mpro and spike protein of SARSCoV-
2. It was observed that amino acid residues MET6, ALA7, PHE8, PRO9, ASP295, GLY302, VAL303,
and THR304 play significant roles in protein-ligand interactions through hydrogen bonds and Vander Waals
forces.

Conclusion:
Silybin B and Cianidanol showed excellent binding and ADME properties compared with the currently
endeavored drugs and can be exploited as therapeutic options against SARS-CoV-2 infection after experimental
validation and clinical trials.
Simulación numérica de flujo de aire en una brida de admisión de un vehículo de competición
Authors: Tolentino Masgo San Luis Baudilio , Campos Omar González , Ponce Clifford Orlando Torres , Figueroa Simón Antonio Caraballo , Hernández Juan Toledo 
Published: December 2020

La brida de admisión es un dispositivo mecánico que restringe la cantidad de flujo másico de aire a ser inyectado al cilindro del motor, y es empleado en vehículos de competición. En el presente trabajo, el flujo de aire se simula en un dominio computacional 2D con simetría axial para la geometría de una brida de admisión convergente-divergente, con el fin de determinar las variaciones de los parámetros termodinámicos del campo de flujo. Para la simulación del flujo, se utilizó el código ANSYS-Fluent que aplica el método de volumen finito. Se emplearon las ecuaciones gobernantes para flujo compresible: ecuación de la masa, cantidad de movimiento, energía y estado; además, se empleó el modelo de turbulencia SST de Menter. Los resultados del campo de flujo de densidad, velocidad, presión y temperatura, así como del número de Mach, para seis relaciones de presión, muestran variaciones de las magnitudes termodinámicas en diferentes regiones del dominio, antes y después de la onda de choque; así como las regiones donde se produce la separación y recirculación del flujo en las adyacencias de la pared divergente. Se concluye que, cuando se presenta el choque, la curvatura de la pared de la sección divergente contribuye con el desprendimiento de la capa límite, causando transición en el desarrollo del flujo. Además, para la presión de salida de , el flujo alcanza un valor máximo de Mach 1.8, y temperatura mínima de 180 K (-93 ºC); y en la salida de la brida el flujo alcanza un valor menor de Mach 1.
Pengembangan keterampilan pemodelan matematis bagi calon guru IPA
Authors: Widodo Wahono , Sari Dhita Ayu Permata , Suyanto Totok , Martini Martini , Inzanah Inzanah 
Published: December 2020

Tingkat keterampilan pemodelan matematis di kalangan mahasiswa calon guru IPA, masih berada dalam kategori cukup dan rendah sehingga perlu ditingkatkan. Pada penelitian ini pengembangan keterampilan pemodelan matematis dilakukan dengan mengaplikasikan model pembelajaran ALLR (activity based, lesson learned, reflection) dalam kegiatan perkuliahan. Penelitian ini dilakukan dengan dua tahap, yaitu tahap persiapan (penyusunan buku model pembelajaran ALLR dan perangkat pembelajaran yang kemudian divalidasi dengan kategori valid) dan tahap penerapan pada Mata Kuliah Dasar-dasar IPA, khususnya materi pegas dan getaran dengan menggunakan desain one shot case study. Subjek penelitian ini adalah mahasiswa calon guru IPA PTN di Jawa Timur Indonesia yang berjumlah 28 mahasiswa. Teknik pengumpulan data dengan menggunakan tes dan rubrik. Data yang diperoleh kemudian dianalisis secara deskriptif kuantitatif dengan representasi yang berupa tabel yang memuat nilai rata-rata, SD, persentase ketuntasan terhadap KKM, dan deskripsi dalam bentuk histogram. Hasil penelitian menunjukkan bahwa Model pembelajaran ALLR dapat digunakan untuk mengembangkan keterampilan matematis bagi calon guru IPA. Adapun saran yang disampaikan adalah keterampilan pemodelan matematis ini masih perlu terus dilatihkan pada berbagai MK yang relevan dengan model pembelajaran ALLR. Developing of mathematical modelling skills for science pre-service teachers AbstractMathematical modelling skills level of pre service teachers is still on average and low category, so it needs to be improved. This study aimed to develop pre service teachers’ mathematical modelling skills by applying the ALLR (activity based, lesson learn, and reflection) learning model. This study was conducted in two stages, namely preparation stage and application stage. The first stage was the stage to prepare the ALLR learning model book, lesson plan, and student worksheet which have a valid category. Second stage was applied the lesson plan and the students worksheet using ALLR learning model to enhance mathematical modelling skills in the Basic Science Course. The topic discussed in this course was spring and vibration. The design of this study was one shot case study design. The subjects were 28 pre-service teachers of East Java, Indonesia. Data were collected by giving a test and rubrics. Then, the data were analysed descriptively and quantitatively in the form of table consist of the students’ achievement. The results showed that the lesson plan and student worksheet applied using ALLR learning model improved pre-service teachers’ mathematical modelling skills. It is suggested that mathematical modelling skills need to be trained in many other courses by applying ALLR learning model.
Pendidikan sains di sekolah menengah pertama perkotaan: Bagaimana sikap dan keaktifan belajar siswa terhadap sains?
Authors: Maison Maison , Kurniawan Dwi Agus , Pratiwi Nur Ika Sandi 
Published: December 2020

Abad ke-21 merupakan abad pengetahuan yang menghendaki segala aktivitas berbasis pada pengetahuan. Pada abad ke-21 ini sangat dibutuhkan keterampilan berpikir kritits, kreatif, kemampuan kolaboratif, metakognitif, kemampuan komunikasi, dan menguasai teknologi komunikasi. Selain itu, sikap dan keaktifan belajar merupakan hal penting yang harus dimiliki peserta didik dalam pembelajaran pada abad ke-21. Oleh karena itu penelitian ini dirancang untuk melihat bagaimana hubungan sikap dengan keaktifan belajar siswa terhadap mata pelajaran IPA. Penelitian ini adalah penelitian mix methods metode asosiatif jenis korelasional. Prosedur penelitian ini dimulai dengan menyebarkan angket, dokumetasi, dan wawancara. Pengambilan data angket data kuesioner diberikan kepada 147 siswa di SMPN 18 Kota Jambi. Dari data tersebut kemudian dilakukan analisis data yaitu pengkodean data, penyariangan data-data yang layak dan analisis dari data tersebut. Teknik analisis data menggunakan uji korelasional untuk mengetahui apakah terdapat hubungan antara sikap dan keaktifan belajar. Hasil dari penelitian ini terdapat hubungan yang positif antara sikap dan keaktifan siswa pada mata pelajaran IPA yang ditunjukkan dari hasil analisis pearson correlation sebesar 0.046. Science education in urban secondary school: How attitude towards science and learning activity? AbstractThe 21st century is the age of knowledge which requires all knowledge-based activities. In the 21st century, critical thinking skills, creative skills, collaborative abilities, metacognitive skills, communication skills, and communication technology are needed. Besides, learning attitudes and activeness are important things that students must have in learning in the 21st century. Therefore this study was designed to see how the relationship between attitudes and student learning activeness in science subjects. This research is mixed-method research with an associative type of correlational method. This research procedure begins with distributing questionnaires, documentation, and interviews. Retrieving questionnaire data was given to 147 students at SMPN 18 Jambi City. From the data, data analysis was then carried out, namely data coding, filtering the appropriate data, and analyzing the data. The data analysis technique uses a correlational test to determine whether there is a relationship between attitudes and learning activeness. The results of this study showed a positive relationship between student attitudes and activeness in science subjects as indicated by the results of the Pearson correlation analysis of 0.046.
Adherence Patterns and Dose Response of Physiotherapy for Rotator Cuff Pathology: Longitudinal Cohort Study
Authors: Burns David , Boyer Philip , Razmjou Helen , Richards Robin , Whyne Cari 
Published: December 2020

Background
Physiotherapy is considered to be essential for the successful operative and nonoperative management of rotator cuff pathology; however, the extent to which patients adhere to assigned physiotherapy activities and how this impacts recovery is unknown.

Objective
The purpose of this study was to measure the rate and patterns of participation in physiotherapy for rotator cuff disorders, assess the dose response between physiotherapy activity and recovery, and explore patient factors predictive of physiotherapy participation.

Methods
We report a prospective longitudinal study of 42 patients undergoing physiotherapy for symptomatic rotator cuff pathology. The patients were issued a smartwatch that recorded inertial sensor data while they performed physiotherapy exercises both in the clinic and in the home setting. A machine learning approach was used to assess total physiotherapy participation from smartwatch inertial data. Primary outcomes were the Disabilities of the Arm Shoulder and Hand and numeric pain rating scale assessed every 4 weeks until 12 weeks follow-up. The relationships between participation, outcomes, and clinical patient variables were assessed in univariable analyses.

Results
Mean physiotherapy exercise participation in clinic and at home were 11 minutes per week and 33 minutes per week, respectively, with patients participating in physiotherapy on 41% of days assigned to treatment. Home physiotherapy participation decreased significantly over time (P=.03). There was a statistically significant and clinically meaningful relationship between cumulative physiotherapy participation and recovery demonstrated by pain scores at 8 weeks (P=.02) and 12 weeks (P=.05) and disability scores at 8 weeks (P=.04) and 12 weeks (P=.04). Low patient expectations and self-efficacy were associated with low rates of physiotherapy participation.

Conclusions
There was a low rate of participation in home shoulder physiotherapy exercise, and a statistically and clinically significant dose response of physiotherapy on treatment outcome in patients with rotator cuff pathology. The findings highlight the opportunity to develop novel methods and strategies to improve the participation in and efficacy of physiotherapy exercises for rotator cuff disorders.

International Registered Report Identifier (IRRID)
RR2-10.2196/17841
Adverse Childhood Experiences and Building Resilience With the JoyPop App: Evaluation Study
Authors: MacIsaac Angela , Mushquash Aislin R , Mohammed Shakira , Grassia Elizabeth , Smith Savanah , Wekerle Christine 
Published: December 2020

Background
The effects of adverse childhood experiences (ACEs) on mental health, self-regulatory capacities, and overall resilience are well-known. Given such effects, ACEs may play a role in how individuals adjust to challenges later in life. Of interest in this study is the transition to university, a time of heightened stress when adapting to circumstances is required and when those with ACEs may need additional in-the-moment support to exercise resilience. A smartphone app may provide a worthwhile and readily accessible medium for a resilience intervention, provided behavioral outcomes are adequately evaluated.

Objective
This study evaluates the impact of an innovative, smartphone app–based resilience intervention. The JoyPop app was designed to promote resilience through the use of self-regulatory skills such as emotion regulation and executive functioning. Among a sample of first-year undergraduate students, we explored whether use of the app would be associated with positive changes in resilience and related outcomes, and whether these benefits were influenced by level of childhood adversity.

Methods
Participants (N=156) were requested to use the JoyPop app for 4 weeks, at least twice daily. Changes in resilience, emotion regulation, executive functioning, and depression were assessed after 2 and 4 weeks of app usage using multilevel modeling.

Results
The sample of 156 participants included 123 females and 33 males, with a mean age of 19.02 years (SD 2.90). On average participants used the app on 20.43 of the possible 28 days (SD 7.14). App usage was associated with improvements in emotion regulation (χ21=44.46; P<.001), such that it improved by 0.25 points on the 18-point scale for each additional day of app usage, and symptoms of depression (χ21=25.12; P<.001), such that depression symptoms were reduced by .08 points on the 9-point scale with each additional day of app usage. An interaction between ACEs and days of app usage existed for emotion regulation, such that participants with more adversity evidenced a faster rate of change in emotion regulation (P=.02).

Conclusions
Results highlight that daily incorporation of an app-based resilience intervention can help youth who have experienced adversity to improve emotion regulation skills and experience reductions in depression. The JoyPop app represents an important step forward in the integration of resilience intervention research with a technology-based medium that provides in-the-moment support.