bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease
Authors: Culjak Marija , Perkovic Matea N. , Uzun Suzana , Strac Dubravka S. , Erjavec Gordana N. , Leko Mirjana B. , Simic Goran , Tudor Lucija , Konjevod Marcela , Kozumplik Oliver , Mimica Ninoslav , Pivac Nela 
Published: December 2020

Background:
Sporadic Alzheimer’s Disease (AD) is assumed to be associated with different
biological/genetic vulnerability, as well as with neuroinflammation, mediated by cytokines. The present
study evaluated the role of cytokines in AD.

Objective:
The aim was to determine the possible association of TNF-α (rs1800629), IL1-α (rs1800587)
and IL-10 (rs1800896) polymorphisms with AD, and to assess serum TNF-α, IL-1α and IL-10 concentrations
in patients with AD and in subjects with mild cognitive impairment (MCI).

Methods:
The study included 645 Caucasian participants: 395 subjects with AD and 250 subjects with
MCI. Genotyping was performed using real-time PCR in all 645 subjects, while serum concentrations of
TNF-α, IL-1α and IL-10 and were determined using ELISA in 174 subjects.

Results:
The frequency of the TNF-α rs1800629, IL1-α rs1800587 or IL-10 rs1800896 genotypes did
not differ significantly between patients with AD and MCI. Serum concentration of IL-1α and IL-10
were significantly decreased, while the concentration of TNF-α was significantly higher in patients with
AD than in MCI subjects. TNF-α, IL1-α or IL-10 concentrations were similar in subjects with AD or
MCI subdivided into carriers of the corresponding TNF-α rs1800629, IL1-α rs1800587 or IL-10
rs1800896 genotypes.

Conclusions:
Similar distribution of the IL1-α rs1800587, TNF-α rs1800629 or IL-10 rs1800896 genotypes
in subjects with AD and MCI failed to confirm that these specific risk genotypes are associated
with vulnerability to develop AD. Alteration in IL-1α, IL-10 and TNF-α concentrations in patients with
AD partially confirmed the association with the neuroinflammatory response in AD.
Efficacy and Safety of Medicines Targeting Neurotrophic Factors in the Management of Low Back Pain: Protocol for a Systematic Review and Meta-analysis
Authors: Rizzo Rodrigo R N , Ferraro Michael C , Wewege Michael A , Cashin Aidan G , Leake Hayley B , O’Hagan Edel T , Jones Matthew D , Gustin Sylvia M , McAuley James H 
Published: December 2020

Background
Low back pain (LBP) is the leading cause of years lived with disability worldwide. Most people with LBP receive the diagnosis of nonspecific LBP or sciatica. Medications are commonly prescribed but have limited analgesic effects and are associated with adverse events. A novel treatment approach is to target neurotrophins such as nerve growth factor (NGF) to reduce pain intensity. NGF inhibitors have been tested in some randomized controlled trials (RCTs) in recent years, showing promise for the treatment of chronic LBP; however, their efficacy and safety need to be evaluated to guide regulatory actions.

Objective
The aim of this study is to evaluate the efficacy and safety of medicines targeting neurotrophins in patients with LBP and sciatica.

Methods
In this systematic review, we will include published and unpublished records of parallel RCTs and the first phase of crossover RCTs that compare the effects of medicines targeting neurotrophins with any control group. We will search the CENTRAL, MEDLINE, Embase, CINAHL, ClinicalTrials.gov, EU Clinical Trials Register, and WHO International Clinical Registry Platform databases from inception. Pairs of authors will independently screen the records for eligibility, and we will independently extract data in duplicate. We will conduct a quantitative synthesis (meta-analysis) with the studies that report sufficient data and compare the medicines of interest versus placebo. We will use random-effects models and calculate estimates of effects and heterogeneity for each outcome. We will assess the risk of bias for each study using the Cochrane Collaboration tool, and form judgments of confidence in the evidence according to GRADE recommendations. We will use the PRISMA statement to report the findings. We plan to conduct subgroup analyses by condition, type of medication, and time point. We will also assess the impact of a potential new trial on an existing meta-analysis. Data from studies that meet inclusion criteria but cannot be included in the meta-analysis will be reported narratively.

Results
The protocol was registered on the Open Science Framework on May 19, 2020. As of December 2020, we have identified 1932 records.

Conclusions
This systematic review and meta-analysis will assess the evidence for the efficacy and safety of NGF inhibitors for pain in patients with nonspecific LBP and sciatica. The inclusion of new studies and unpublished data may improve the precision of the effect estimates and guide regulatory actions of the medications for LBP and sciatica.

Trial Registration
Open Science Framework; https://osf.io/b8adn/

International Registered Report Identifier (IRRID)
DERR1-10.2196/22905
The Vision for the Future of Mobility
Authors: Bell Donna L. , Gluesing Julia C. 
Published: December 2020

The automotive industry is going through a transformation. Disruptive technologies and tools are shifting the business model from one of automobiles to one of mobility. To accomplish this shift, automotive companies are embracing acquisitions and partnerships. In a time when the consumer electronics industry is delivering new products to market at a rapid rate, automotive manufacturers must identify ways of getting new products and features to customers faster and with high quality to maintain or increase market share. We provide an analysis of interviews with global automotive company professionals to understand the impact that quality requirements have on innovation and the advanced product design process. The research contributes to the literature on innovation and quality, identifying organizational behaviors and practices that facilitate or obstruct the development of high quality fast-to-market innovations, particularly in the area of mobility.
Design and Economic Analysis of a Grid-connected Rooftop Solar PV System for Typical Home Applications in Oman
Authors: Ahshan Razzaqul , Al-Hanshi A. M. , Al-Naabi M. A. , Al-Hashmi H. A. , Al-Badi A. H. 
Published: December 2020

This paper presents a techno-economic investigation of an integrated rooftop solar PV system for typical home applications in Oman that can reduce the power consumption from the grid and export excess PV generated power back to the gird. Since renewable energy systems design echnically depends on the site, this study selects a typical two-story villa (Home), in a site Al-Hamra, Oman. Temperature is one of the critical parameters in this design as it varies widely over the day and from one season to another in Oman. With the effect of temperature variation, the PV system has designed using system models for the required load of the home. The design process has included two main design constraints, such as the available rooftop space and the grid-connection availability for the selected home.This research also evaluates the economic feasibility of the design system considering the energy export tariff as per the Bulk Supply Tariff (BST) scheme in Oman. The design outcome reveals that the designed PV system can supply the load energy requirement in a year. In addition, the rooftop solar PV system can sell surplus energy back to the grid that generates additional revenue for the owner of the system. The economic performance indices such as payback period, internal rate of return, net present value,and profitability index ensure the financial feasibility of the designed rooftop solar PV system for the selected home.
PENGARUH KEMANDIRIAN BELAJAR DAN MINAT BELAJAR TERHADAP PRESTASI BELAJAR MATEMATIKA SISWA SMA
Authors: Ina Ledun Rosalia Fransiska , H. Kaluge Agapitus , Joakim Fernandez Aloysius 
Published: December 2020

Tujuan dari penelitian ini untuk mengetahui pengaruh kemandirian belajar dan minat belajar siswa SMA. Jenis dari penelitian ini yaitu penelitian kuantitatif dengan menggunakan analisis regresi berganda. Sampel dalam penelitian ini kelas XI IIS yang berjumlah 34 orang yang dipilih secara acak. Jenis datanya yaitu data primer. Alat pengumpulan data yang digunakan yaitu angket dan tes prestasi belajar matematika. Teknis analisis data dalam penelitian ini menggunakan analisis regresi ganda. Berdasarkan hasil uji parsial pada kemandirian belajar menunjukkan bahwa sehingga kemandirian belajar mempunyai pengaruh terhadap prestasi belajar matematika dan pada minat belajar diperoleh sehingga ada pengaruh yang tidak signifikan minat belajar terhadap prestasi belajar matematika. Selanjutnya, pada uji secara simultan menunjukkan bahwa maka terdapat pengaruh simultan pada kemandirian belajar dan minat belajar terhadap prestasi belajar matematika. Dengan demikian dapat disimpulkan bahwa ada pengaruh kemandirian belajar dan minat belajar terhadap prestasi belajar matematika
Comparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study
Authors: Kim Jinuk , Kim Heegoo , Lee Jungsoo , Lee Hwang-Jae , Na Yoonju , Chang Won Hyuk , Kim Yun-Hee 
Published: December 2020

Background: Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. Objective: The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) and the hand motor hotspot (hMHS) in the dominant motor cortex. Methods: Ten healthy right-handed participants without a history of neurological or psychiatric symptoms (five males; 29.8±2.8 years) participated in this single-blind, randomized, cross-over study. rTMS was applied under three conditions over the dominant (left) hemisphere for 20 minutes: 1) 1 Hz rTMS stimulation on the HK (HK-rTMS), 2) 1 Hz rTMS stimulation on the hMHS (hMHS-rTMS), and 3) sham stimulation (Sham-rTMS). For all participants, functional near-infrared spectroscopy (fNIRS) was applied for measurement of cerebral oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb) concentration over the non-dominant (right) hemisphere during a serial reaction time task (SRTT) with the non-dominant (left) hand before and after each condition. Results: The average coordinates of the hMHS (x = – 39.60 mm, y = – 17.11 mm, z = 66.40 mm) were anterior and lateral to the HK (x = – 36.72 mm, y = – 28.87 mm, z = 56.41 mm). In fNIRS time-series analysis, the integral value of oxyHb was significantly increased over the motor cortical region of the non-dominant hemisphere after the hMHS-rTMS compared with Sham-rTMS. The HK-rTMS also showed slight increment of oxyHb concentration but without statistical significance. The SPM group analysis showed greater magnitude of the activity in hMHS-rTMS than that of HK-rTMS after stimulation ( p < 0.05). Conclusions: These results demonstrated an interhemispheric modulation effect of hemodynamic changes by 1 Hz rTMS. The hMHS produced a more robust modulation effect of 1 Hz rTMS on the contralateral hemisphere than did the HK. Therefore, the rTMS can be considered a better stimulation target than the HK.
The Effect of the Way of Using Social Media on Health Promoting Behaviors and COVID-19-related Anxiety in Non-medical Students
Authors:   NAJA Research Institute of Law Enforcement Sciences and Social Studies, Tehran, Iran., Fathi Ayatollah , Sadeqi Solmaz ,   Department of Psychology, Charkh Niloufari Institute, Tabriz, Iran., Sharifi Rahnemou Saeid ,   Department of Psychology, Faculty of Economics and Social Sciences, Bu Ali University, Hamadan, Iran., Malekirad Aliakbar ,   Department of Psychology, Payam Noor University, Arak, Iran., Rostami Hosein ,   NAJA Research Institute of Law Enforcement Sciences and Social Studies, Tehran, Iran., Rostami Raheleh ,   Department of Psychology, Charkh Niloufari Institute, Tabriz, Iran.
Published: December 2020

Background: One of the problems of today's Iranian youth is how to use social media coincided with the outbreak of Coronavirus Disease 2019 (COVID-19). Objective: This study aimed to investigate the way of use of social media and its effect on health promoting behaviors and COVID-19-related anxiety in non-medical students. Methods: In this analytical study, participants were 307 non-medical students of Islamic Azad University of Tabriz Branch. Data collection tools were a demographic form, Corona Disease Anxiety Scale (CDAS) with two subscales of psychological and physical symptoms, and Health Promoting Lifestyle Profile (HPLP) with six subscales of spiritual growth, health responsibility, interpersonal relations, stress management, physical activity, and nutrition which were completed online. The multivariate analysis of variance and a post-hoc test were used for data analysis. Findings: Of 307 participants, 256 were female (83%) and 51 were male (16.6%), with a mean age of 27 years. The HPLP components of spiritual growth (P=0.001), health responsibility (P=0.001), stress management (P=0.001), physical activity (P=0.002), and its overall score (P=0.001) had a significant relationship with the way of use of the Internet, and the group with a fun purpose had lower scores in these variables compared to other groups. Moreover, the CDAS component of psychological symptoms (P=0.007) and its overall score (P=0.03) had a significant relationship with the way of using social media; the group with a fun purpose reported higher CDAS score than the groups with scientific and general information acquiring purposes. Conclusion: The use of social media for fun negatively affects the students’ lifestyle in the current coronavirus outbreak and increases their COVID-19-related anxiety.
Analisis Value Chain Management pada Usaha Mikro Kecil dan Menengah di Indonesia
Authors: Suseno Agustian , Arifin Jauhari , Sutrisno Sutrisno 
Published: December 2020

Usaha Mikro Kecil dan Menengah (UMKM) memiliki peran yang sangat strategis dalam perekonomian Indonesia. Namun demikian, para pelaku UMKM masih memiliki keterbatasan, seperti kualitas produk, keterbatasan permodalan, dan jaringan pemasaran. Salah satu solusi untuk mengatasi keterbatasan tersebut adalah memperkuat UMKM melalui analisis value chain management. Value chain (rantai nilai) merupakan jalan dalam mengkonseptualkan aktivitas yang diperlukan dalam menciptakan nilai dari produk atau jasa. Lingkungan yang kondusif bagi UMKM dapat memastikan kolaborasi yang optimal dengan para pemangku kepentingan di pemerintahan, entitas bisnis yang beragam, serta dunia pendidikan. Kolaborasi diarahkan untuk berpikir strategis dalam menciptakan nilai produk atau jasa. UMKM juga harus fokus pada tingkat integritas unit bisnisnya. Dalam rantai nilai dioptimalkan melalui analisis value chain manajemen yang bernilai excellent. Jadi UMKM bisa diarahkan agar memiliki performance yang superior melalui analisis prinsip operasional value chain manajemen yang efektif serta strategic positioning yang tepat pada rantai nilainya agar bisa bertahan dan berkembang lebih maju lagi. Hasil studi ini menunjukkan bahwa para pelaku UMKM harus mengenali konsumen melalui diferensiasi produk atau jasa, mengkomunikasikan keunggulan, kekhasan, keunikan, dan digitalisasi proses bisnis serta strategic positioning yang tepat, sehingga dapat mendorong bisnis menjadi optimal serta akan memastikan UMKM bertahan dan bahkan mendapatkan keuntungan yang lebih optimal.
The K2 Galactic Archaeology Program Data Release 2: Asteroseismic Results from Campaigns 4, 6, and 7
Authors: Zinn Joel C. , Stello Dennis , Elsworth Yvonne , García Rafael A. , Kallinger Thomas , Mathur Savita , Mosser Benoît , Bugnet Lisa , Jones Caitlin , Hon Marc , Sharma Sanjib , Schönrich Ralph , Warfield Jack T. , Luger Rodrigo , Pinsonneault Marc H. , Johnson Jennifer A. , Huber Daniel , Aguirre Victor Silva , Chaplin William J. , Davies Guy R. , Miglio Andrea 
Published: December 2020

Abstract
Studies of Galactic structure and evolution have benefited enormously from Gaia kinematic information, though additional, intrinsic stellar parameters like age are required to best constrain Galactic models. Asteroseismology is the most precise method of providing such information for field star populations en masse, but existing samples for the most part have been limited to a few narrow fields of view by the CoRoT and Kepler missions. In an effort to provide well-characterized stellar parameters across a wide range in Galactic position, we present the second data release of red giant asteroseismic parameters for the K2 Galactic Archaeology Program (GAP). We provide

ν

max

and

Δ
ν

based on six independent pipeline analyses; first-ascent red giant branch (RGB) and red clump (RC) evolutionary state classifications from machine learning; and ready-to-use radius and mass coefficients, κ

R
and κ

M
, which, when appropriately multiplied by a solar-scaled effective temperature factor, yield physical stellar radii and masses. In total, we report 4395 radius and mass coefficients, with typical uncertainties of 3.3% (stat.) ± 1% (syst.) for κ

R
and 7.7% (stat.) ± 2% (syst.) for κ

M
among RGB stars, and 5.0% (stat.) ± 1% (syst.) for κ

R
and 10.5% (stat.) ± 2% (syst.) for κ

M
among RC stars. We verify that the sample is nearly complete—except for a dearth of stars with

ν

max

≲
10
–
20

μ
Hz

—by comparing to Galactic models and visual inspection. Our asteroseismic radii agree with radii derived from Gaia Data Release 2 parallaxes to within 2.2% ± 0.3% for RGB stars and 2.0% ± 0.6% for RC stars.
The NASA Ames PAH IR Spectroscopic Database: The Laboratory Spectra
Authors: Mattioda A. L. , Hudgins D. M. , Boersma C. , Bauschlicher C. W. , Ricca A. , Cami J. , Peeters E. , de Armas F. Sánchez , Saborido G. Puerta , Allamandola L. J. 
Published: December 2020

Abstract
The astronomical emission features, formerly known as the unidentified infrared bands, are now commonly ascribed to polycyclic aromatic hydrocarbons (PAHs). The laboratory experiments and computational modeling performed at NASA Ames Research Center generated a collection of PAH IR spectra that have been used to test and refine the PAH model. These data have been assembled into the NASA Ames PAH IR Spectroscopic Database (PAHdb). PAHdb’s library of computed spectra, currently at version 3.20, contains data on more than 4000 species and the library of laboratory-measured spectra, currently at version 3.00, contains data on 84 species. The spectra can be perused and are available for download at www.astrochemistry.org/pahdb/. This paper introduces the library of laboratory-measured spectra. Although it has been part of PAHdb since its inception, the library of laboratory-measured spectra lacked a proper description in the literature. Here, the experimental methods used to obtain the data are described in detail, an overview of the contents of the experimental library is given, and specific tools developed to analyze and interpret astronomical spectra with the laboratory data are discussed. In addition, updates to the website, documentation and software tools since our last reporting are presented. Software tools to work with the spectroscopic libraries are being developed actively and are available at GitHub. Lastly, a comprehensive demonstration showing how the laboratory-measured data can be applied to explore absorption features in observations toward embedded sources is presented. This demonstration suggests that PAHs very likely contribute to interstellar absorption spectra associated with dense clouds and underscores the need for further IR spectroscopic studies of PAHs trapped in water ice.
Fecal Microbiota in Untreated Children With Juvenile Idiopathic Arthritis: A Comparison With Healthy Children and Healthy Siblings
Authors: Öman Anders , Dicksved Johan , Engstrand Lars , Berntson Lillemor 
Published: December 2020

ObjectiveChanges in the composition of gut microbiota have been suggested to be associated with juvenile idiopathic arthritis (JIA). The objective in this study was to investigate if the diversity and composition of the fecal microbiota differed between children with JIA and healthy controls (HCs), and if the microbiota differed between children with JIA and their healthy siblings.MethodsIn this multicenter, case-control study, fecal samples were collected from 75 children with JIA and 32 HCs. Eight of the HCs were siblings to 8 children with JIA, and they were compared only pairwise with their siblings. The microbiota was determined using sequencing amplicons from the V3 and V4 regions of the 16S rRNA gene. Alpha diversity, community composition of microbiota, and relative abundances of taxa were compared between children with JIA and healthy unrelated controls as well as between children with JIA and healthy siblings.ResultsOur data revealed no significant differences in α-diversity or community composition of microbiota between children with JIA, healthy unrelated controls, or healthy siblings. Analyses of relative abundances of phyla, families, and genera identified trends of differing abundances of some taxa in children with JIA, in comparison with both HCs and healthy siblings, but none of these findings were significant after adjustment for multiple comparisons.ConclusionThere were no significant differences in the composition of fecal microbiota in children with JIA compared with HCs. The composition of microbiota in children with JIA did not differ significantly from that in their healthy siblings.
The Problem of Pain in Systemic Lupus Erythematosus: An Explication of the Role of Biopsychosocial Mechanisms
Authors: Falasinnu Titilola , Drenkard Cristina , Bao Gaobin , Mackey Sean , Lim S. Sam 
Published: December 2020

ObjectiveTo define biopsychosocial mechanisms of pain that go above and beyond disease activity and organ damage in systemic lupus erythematosus (SLE).MethodsWe conducted a cross-sectional analysis of patient-reported data in a population-based registry of 766 people with SLE. Predictors of pain intensity and interference were examined using hierarchical linear regression. We built 2 main hierarchical regression models with pain intensity and interference as outcomes, both regressed on disease activity and organ damage. For each model, we sought to establish the relationship between pain outcomes and the primary exposures using sequential steps comprising the inclusion of each construct in 6 stages: demographic, socioeconomic, physical, psychological, behavioral, and social factors. We also conducted sensitivity analyses eliminating all overt aspects of pain in the disease activity measure and reestimated the models.ResultsDisease activity and organ damage explained 32–33% of the variance in pain intensity and interference. Sociodemographic factors accounted for an additional 4–9% of variance in pain outcomes, whereas psychosocial/behavioral factors accounted for the final 4% of variance. In the sensitivity analyses, we found that disease activity and organ damage explained 25% of the variance in pain outcomes.ConclusionDisease activity only explained 33% of the variance in pain outcomes. However, there was an attenuation in these associations after accounting for psychosocial/behavioral factors, highlighting their roles in modifying the relationship between disease activity and pain. These findings suggest that multilevel interventions may be needed to tackle the negative effect of pain in SLE.