bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Chemotherapy Integrated With Traditional Korean Medicine in Patients With Metastatic Pancreatic Cancer: A Single-Center Retrospective Study
Authors: Kim Eun Hye , Yoon Jee-Hyun , Yoon Sung Soo , Lee Jee Young , Yoon Seong Woo 
Published: December 2020

Background: This retrospective study investigated the efficacy and safety of chemotherapy (CTX) integrated with Traditional Korean Medicine (TKM) in patients with metastatic pancreatic cancer, in a single Korean center. Methods: From January, 2014 to February, 2019, patients with metastatic pancreatic cancer who had received CTX were enrolled. Overall survival (OS), demographic characteristics, and adverse events were examined. Statistical analysis was utilized to evaluate the differences in characteristics and to compare the survival rates between the CTX group and CTX+TKM group. Kaplan-Meier curves were used to compare the differences in survival time. A Cox regression analysis was performed to determine the hazard ratio of the risk of mortality. Results: A total 37 participants were included and visited a TKM hospital 7.4 ± 8.3 months after being diagnosed with metastatic pancreatic cancer. The median age of the participants was 62 years; 26 patients (70.3%) had an Eastern Cooperative Oncology Group (ECOG) performance status between 0 and 2, and 23 patients (62.2 %) had first-line CTX failure. The median OS of all patients was 3.8 months (95% CI, 3.1-4.6). The CTX + TKM group showed longer survival (4.1 months; 95% CI, 2.4- .8) than the CTX group (2.4 months, 95% CI 0.2-4.6) but this was not statistically significant ( P = .217). Chemotherapy with TKM treatment for more than 30 days (CTX + TKM ≥ 30) significantly prolonged median OS (9.1 months; 95% CI, 3.6-14.5; P = .025) compared to chemotherapy alone. Cox hazard ratio analysis revealed that CTX + TKM ≥ 30 and prior chemotherapy were significantly independent prognostic factors for OS. The main herbs in the TKM treatment were Rhus verniciflua Stokes and Astragalus. Severe adverse events with respect to TKM treatment were not reported. Conclusions: TKM treatment integrated with chemotherapy may prolong OS in patients with metastatic pancreatic cancer compared to chemotherapy treatment alone. More rigorous prospective clinical trials are needed to confirm this result.
A systematic review and meta-analysis of neurotrophic tyrosine receptor kinase gene fusion frequencies in solid tumors
Authors: Forsythe Anna , Zhang Wei , Phillip Strauss Uwe , Fellous Marc , Korei Maesumeh , Keating Karen 
Published: December 2020

Introduction: The research objective was to systematically review evidence on neurotrophic tyrosine receptor kinase ( NTRK) gene fusion frequency in solid tumors. Methods: Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review (SLR) was conducted of studies published from January 1987 to 2 January 2020. Selected studies were appraised for use in meta-analysis, with frequency reported as a point estimate with confidence intervals, to estimate NTRK gene fusion tumor incidence and prevalence. Results: The SLR identified 222 studies from North America ( n = 122), Europe ( n = 33), Asia ( n = 41), Brazil ( n = 5), Australia ( n = 2), and multi-continental ( n = 19) reporting NTRK gene fusion frequencies across 101 histologies. Studies were prospective ( n = 43) and retrospective ( n = 179). Testing methods involved DNA ( n = 93), RNA ( n = 72), combined DNA/RNA ( n = 48), protein [immunohistochemistry (IHC), n = 5], and unreported ( n = 5). Sample sizes ranged from 1 to 66,871. Of the 222 studies, 107 were suitable for meta-analysis. Highest NTRK gene fusion frequencies were reported in rare cancers: infantile/congenital fibrosarcoma (90.56%, 95% CI 67.42–100.00), secretory breast cancer (92.87%, 95% CI 72.62–100.00), and congenital mesoblastic nephroma (21.52%, 95% CI 13.06–32.20). Lower frequencies were reported in non-small cell lung cancer (0.17%, 95% CI 0.09–0.25), colorectal adenocarcinoma (0.26%, 95% CI 0.15–0.36), cutaneous melanoma (0.31%, 95% CI 0.07–0.55), and non-secretory breast carcinoma (0.60%, 95% CI 0.00–1.50). Reported frequency was ~0% for some cancers: mesothelioma, renal cell carcinoma, prostate cancer, and bone sarcoma. Estimated global overall NTRK gene fusion tumour incidence and 5-year prevalence in 2018 was 0.52 and 1.52 per 100,000 persons, respectively. Conclusion: This research confirms the rarity and varying frequency of NTRK gene fusion across tumor types. Limitations included relatively low historic NTRK gene fusion testing and reporting, limited study samples for some cancers, and suboptimal molecular testing methods. In this rapidly developing area, gold-standard testing methods and companion diagnostics are needed to capture all NTRK gene fusions.
High volume distension injection (HVDI) for chronic mid-portion Achilles tendinopathy: A service evaluation of clinical outcomes
Authors: Edwards Samuel , Sivan Manoj 
Published: December 2020

Purpose: High Volume Distension Injection (HVDI) is a treatment adjunct in chronic mid-portion Achilles tendinopathy. This study analysed whether HVDI is safe and effective in an outpatient clinic setting. Methods: Retrospective service evaluation of 18 participants over 18 months. Ultrasound-guided saline, corticosteroid and bupivacaine was injected to disrupt vasculo-neural ingrowth, with post-procedure eccentric exercises. Mean follow-up was 8 weeks. Outcomes used were Numeric rating Scale (NRS) of pain, tendon thickness and Modified Ohberg score (MOS) of neovascularisation measured on Ultrasound and Doppler imaging. Results: Mean reduction in NRS was 5.30 ± 2.53 ( P < 0.001). Mean tendon thickness reduction was 0.21 ± 0.17 cm ( P < 0.001). Median MOS improved from 2.00 ± 2.00 to 1.00 ± 3.00 ( P = 0.009). No complications occurred. 11 participants had successful primary HVDI, 3 responded to a second injection. Two non-responders were referred for surgery and two referred for alternative therapy by patient preference. Conclusion: Significant reduction in pain, tendon thickness and neovascularity was observed in 78% of patients. Recurrence in 39%. HVDI with eccentric training is safe and effective intervention in outpatient clinic setting.
Reading outcomes in children with developmental language disorder: A person-centered approach
Authors: Erisman Marja C , Blom Elma 
Published: December 2020

Background and aims Many children with Developmental Language Disorder (DLD) develop reading difficulties. The purpose of this study is to better understand variation in the reading outcomes of children with DLD using a person-centered approach. Method 87 monolingual Dutch children diagnosed with DLD performed at ages 5 or 6 years nine tests of nonverbal IQ, oral language proficiency, phonological memory (PM) and executive functioning (EF). Two years later, the same children were tested on single (non-)word reading. Latent profile analyses were conducted to identify profiles based on oral language proficiency, phonological memory and executive functioning at age 5–6 years, which, in turn, were related to nonverbal IQ and to single-word reading two years later. Results Four profiles were identified and labelled relative to their position within the DLD-sample: 1. Weak performance overall, 2. Strong EF-average language and PM, 3. Mild working memory (WM) deficiencies-average language and PM, 4. Strong development overall. Profiles 1 and 3 had below average nonverbal IQ scores and were associated with low word reading outcomes two years later. Conclusions Within the group of children with DLD, children with relatively weak oral language, phonological memory and executive functioning, or children with working memory deficiencies are most at risk for developing reading difficulties. The findings support a multiple risk framework and confirm that a person-centered approach is promising in predicting reading outcomes in DLD. Implications: Research into individual differences in DLD is dominated by variable-centered approaches. This study illustrates how a person-centered approach, which views variables as properties of individuals, captures variation in the DLD-population. Using this bottom-up approach, the study highlights how an individual’s strengths and weaknesses across different developmental domains can be combined into profiles that relate to later reading outcomes. As such, it can provide an example for future DLD research.
Lens and Peripheral Retinal Relationships During Vitrectomy: Comparison of 23-, 25-, and 27-Gauge Vitrectomy and Curved Endolaser Probes
Authors: Duker Jacob S. , Venincasa Michael J. , Monsalve Pedro F. , Garcia Armando L. , Dubovy Sander R. , Smiddy William E. , Sridhar Jayanth 
Published: December 2020

Purpose: This work aims to compare spatial relationships between the crystalline lens and vitrectomy instruments of different gauges. Methods: Eight phakic eyes recovered from deceased donors were used after fixation. Valved trocars (27-gauge, 25-gauge, and 23-gauge) were sequentially placed in the superotemporal quadrant 4 mm posterior to the limbus in each eye. Intraocular relationships of vitrectomy and curved endolaser probes were measured for each gauge. Results: There were no significant differences in maneuverability between instruments of different gauges. The mean distance from instrument to lens at the geometric center of the globe was 5.5 mm. Vitrectomy probes of all gauges could access the peripheral retina on both sides of the sclerotomy in the 3 to 4 o’clock position adjacent to the sclerotomy without touching the lens. The instruments could be advanced without lens touch to contact the retina within at least 2 mm of the ora serrata 180° away from the insertion site. Conclusions: Vitrectomy and curved endolaser probes achieved similar maneuverability relative to the lens regardless of gauge. This study confirms that small-gauge vitrectomy instruments have a considerable range of safe access to the peripheral retina in phakic eyes from a single sclerotomy.
Slippery ontologies of tidal flats
Authors: Choi Young Rae 
Published: December 2020

Tidal flats are a type of coastal space that flood at high tides and are exposed at low tides—not quite land or sea. Distinct from open waters or seabeds, tidal flats’ in-betweenness gives them particular materialities that constantly frustrate our efforts to know them. Inspired by the provocation of recent scholarship on “wet ontologies” while simultaneously recognizing the nuances within water worlds, I argue for the slippery ontologies of tidal flats and explore the implications of this approach. Specifically, this paper shows how tidal flats’ dynamic and ambiguous materialities resist attempts to place them into modern knowledge systems.  Drawing upon the particular case of South Korea’s tidal flats, called getbol, I first interrogate the in-betweenness of tidal flats, a major source of their material and conceptual slipperiness. I then discuss the similarities and differences between tidal flats and other types of land–water spaces. Next, through several interviews with those who produce modern scientific knowledge of getbol, I examine how tidal flats’ unique compositions interfere with modernity’s efforts to measure their boundaries, matter, and verticality. I highlight how both non-humans and humans contribute to tidal flats’ slipperiness. Finally, I show how the slippery nature of tidal flats has threatened their survival. In South Korea alone, more than half the tidal flats were removed due to reclamation efforts in the past century. In this context, I contend that fully embracing tidal flats’ slippery ontologies may prevent them from further endangerment.
Role of Factor V R2 Haplotype and Common Thrombophilia Markers as Genetic Risk Factors for Ischemic Stroke
Authors: Michele Manuela De , Lorenzano Svetlana , Angelosanto Noemi , Serrao Alessandra , Petraglia Luca , Risitano Angela , Toni Danilo , Chistolini Antonio 
Published: December 2020

Background: Uncertainties remain about the role of common thrombophilia markers as determinants of the ischemic stroke (IS) risk. Polymorphism His1299Arg in the FV gene, named R2 haplotype (FVHR2), has been poorly investigated. The aim of the present study was to assess the prevalence of common thrombophilia markers and of FVHR2 in a cohort of IS patients compared to a nonmatched group of healthy individuals. Methods: We studied 156 consecutive patients survivors of a first ever IS and 124 healthy controls. All subjects were investigated for the gene polymorphisms factor V (FV) Leiden, prothrombin (PTH) G20210A, MTHFR C677T, and FVHR2. Protein C (PC), protein S (PS), antithrombin (ATIII), and lupus anticoagulant (LAC) activity was measured. Homocysteinemia was assessed within 48 hours and after 30 days from stroke onset. Univariate and multivariate analyses were performed. Results: Compared with controls, patients were significantly older (mean [SD] age, 50.5 [12.9] vs 37.5 [15.5] years, P < .001), less frequently females (48.1% vs 67.7%, P = .001) and had more frequently hyperhomocysteinemia (45.9% vs 11.0%) only in the acute phase (OR 6.899, CI 95% 2.993-15.899; P < .001). No differences were found in the prevalence of FV Leiden, PTH G20210A, and MTHFR C677T between patients and controls, whereas FVHR2 was present in 34/156 (22%) stroke patients and in 5/124 (4%) controls (OR 6.632, 95% CI 2.509-17.535, P < .001). In a multivariate logistic regression analysis, the FVHR2 resulted independently associated with the occurrence of IS (OR 6.071, 95% CI 1.762-20.923; P = .004). Conclusions: In our study, hyperhomocysteinemia was confirmed to be a transient consequence of the thrombotic event. FVHR2 seems to be a possible candidate prothrombotic condition related to arterial IS irrespective of age and sex in an Italian sample population.
The benefits of a systematic assessment of respiratory health in illness-susceptible athletes
Authors: Hull James H. , Jackson Anna R. , Ranson Craig , Brown Freddie , Wootten Moses , Loosemore Mike 
Published: December 2020

Respiratory tract illness is a leading cause of training and in-competition time loss in elite athletes. Asthma is known to be prevalent in athletes, but the coexistence of other respiratory problems in those deemed to be susceptible to respiratory tract illness is unknown. The aim of this study was to apply a comprehensive prospective approach to identify respiratory problems and explore relationships in athletes with heightened respiratory illness susceptibility.UK World Class Performance Programme athletes prospectively completed a systematic review of respiratory health with validated questionnaires and respiratory-focused investigations, including studies of nasal flow, exhaled nitric oxide, spirometry, bronchoprovocation testing and allergy testing.Systematic respiratory health assessment was completed by 122 athletes (55 females, mean±sdage 24±4 years). At least one respiratory health issue, requiring intervention, was identified in 97 (80%) athletes and at least two abnormalities were found in 73 (60%). Sinonasal problems were the most commonly identified problem (49%) and 22% of athletes had a positive indirect bronchoprovocation test. Analysis revealed two respiratory health clusters: 1) asthma, sinus problems and allergy; and 2) laryngeal and breathing pattern dysfunction. Respiratory illness susceptible athletes had 3.6±2.5 episodes in the year prior to assessment and were more likely to have allergy (OR 2.6, 95% CI 1.0–6.5), sinonasal problems (2.6, 1.1–6.0) and symptoms of laryngeal (5.4, 1.8–16.8) and breathing pattern dysfunction (3.9, 1.1–14.0) than nonsusceptible athletes (all p<0.05).A systematic approach to respiratory assessment identifies a high prevalence and coexistence of multiple respiratory problems in illness-susceptible athletes.
Exploring the Process of Cancer Care for Patients With Pre-Existing Mobility Disability
Authors: Agaronnik Nicole D. , El-Jawahri Areej , Lindvall Charlotta , Iezzoni Lisa I. 
Published: December 2020

PURPOSE: Approximately 13% of the US population report mobility disability. People with mobility disability experience healthcare disparities, including lower rates of cancer screening and substandard cancer care compared with nondisabled people. We explored clinicians' reports of aspects of diagnosing and treating three common cancer types among persons with pre-existing mobility disability. METHODS: We used standard diagnosis codes and natural language processing to screen electronic health records (EHR) in the Research Patient Data Repository for patients with pre-existing chronic mobility impairment who were newly diagnosed with one of three common cancers (colorectal, prostate, and non-Hodgkin lymphoma) between 2005 and 2017. We eliminated numerous cases whose EHRs lacked essential information. We reviewed EHRs of 27 cases, using conventional content analysis to identify themes concerning their cancer diagnoses and treatments. RESULTS: Clinicians' notations coalesced around four major themes: (1) patients' health risks raise concerns about diagnostic processes; (2) cancer signs or symptoms can be erroneously attributed to the patient's underlying disabling condition, delaying diagnosis; (3) disability complicates cancer treatment decisions; and (4) problems with equipment accessibility and disability accommodations impede cancer diagnoses. DISCUSSION: Clinicians view patients with pre-existing mobility disability as often clinically complex, presenting challenges for diagnosing and treating their cancer. Nonetheless, these patients may experience substandard care because of disability-related problems. Given the growing population of people with mobility disability, further efforts to improve care quality and timeliness of diagnosis are warranted.
Entangled photons from subwavelength nonlinear films
Authors: Santiago-Cruz Tomás , Sultanov Vitaliy , Zhang Haizhong , Krivitsky Leonid A. , Chekhova Maria V. 
Published: December 2020

Miniaturized entangled photon sources, in particular based on subwavelength metasurfaces, are highly demanded for the development of integrated quantum photonics. Here, as a first step towards the development of quantum optical metasurfaces (QOMs), we demonstrate generation of entangled photons via spontaneous parametric down-conversion (SPDC) from subwavelength films. We achieve photon pair generation with a high coincidence-to-accidental ratio in lithium niobate and gallium phosphide nanofilms. By implementing the fiber spectroscopy of SPDC in nanofilms, we measure a spectrum with a bandwidth of 500 nm, limited only by the overall detection efficiency. The spectrum reveals vacuum field enhancement due to a Fabry–Perot resonance inside the nonlinear films. It also suggests a strategy for observing SPDC from QOM. Our experiments lay the groundwork for future development of flat SPDC sources, including QOM.
Digitalisierungsprojekt Bibliografie der Wiedergeburt Bulgariens in Sofia
Authors: Encheva Marina , Krüger Nicole , Zagorov Vasil , Zlatkova Plamena , Angelova Gabriela 
Published: December 2020

Zusammenfassung
In der Zeit der nationalen Wiedergeburt Bulgariens im 19. Jh. wurden seit dem Beginn der ausländischen Besetzung durch das Osmanische Reich erstmals gedruckte Bücher in bulgarischer Sprache veröffentlicht. Aufgrund eines generellen Verbots von Druckerpressen in den bulgarisch-sprachigen Gebieten zur damaligen Zeit wurden die Schriften in einem weitläufigen geografischen Raum gedruckt, der von Moskau bis nach New York reichte. Im Projekt „Digitalization of the repertoire of books from the Bulgarian Revival (1801–1878)“, gefördert durch den Bulgarischen wissenschaftlichen Nationalfond, wurden die Werke dieser Periode nun erstmals in einer Online-Bibliografie vollständig nachgewiesen und mit den vorhandenen Volltext-Digitalisaten aus den verschiedenen Bibliotheken und Museen Bulgariens verknüpft. Die im Rahmen des Projekts entwickelte Webseite bietet zahlreiche Sucheinstiege und Filter, eingebettete Tastaturen für arabische, kyrillische, griechische und lateinische Schrift sowie ein geografisches Informationssystem mit Visualisierungen und einem topografischen Index.
Single-valued integration and double copy
Authors: Brown Francis , Dupont Clément 
Published: December 2020

Abstract
In this paper, we study a single-valued integration pairing between differential forms and dual differential forms which subsumes some classical constructions in mathematics and physics.
It can be interpreted as a p-adic period pairing at the infinite prime.
The single-valued integration pairing is defined by transporting the action of complex conjugation from singular to de Rham cohomology via the comparison isomorphism. We show how quite general families of period integrals admit canonical single-valued versions and prove some general formulae for them. This implies an elementary “double copy” formula expressing certain singular volume integrals over the complex points of a smooth projective variety as a quadratic expression in ordinary period integrals of half the dimension. We provide
several examples, including non-holomorphic modular forms, archimedean Néron–Tate heights on curves, single-valued multiple zeta values and polylogarithms.
The results of the present paper are used in [F. Brown and C. Dupont,
Single-valued integration and superstring amplitudes in genus zero,
preprint 2019, https://arxiv.org/abs/1910.01107] to prove a recent conjecture of Stieberger which relates the coefficients in a Laurent expansion of two different kinds of periods of twisted cohomology on the moduli spaces of curves

ℳ

0
,
n

{\mathcal{M}_{0,n}}

of genus zero with n marked points. We also study a morphism between certain rings of “motivic” periods, called the de Rham projection,
which provides a bridge between complex periods and single-valued periods in many situations of interest.
The Historian’s Role, Public History, and the National Truth Commission in Brazil
Authors: Quadrat Samantha Viz 
Published: December 2020

Abstract
In 2011, twenty-six years after the end of the military dictatorship, the Brazilian government took the initiative of implementing the right to memory and to the truth, as well as promoting national reconciliation. A National Truth Commission was created aiming at examining and shedding light on serious human rights violations practiced by government agents from 1946 to 1985. It worked across the entire national territory for almost three years and established partnerships with governments of other countries in order to investigate and expose the international networks created by dictatorships for monitoring and persecuting political opponents across borders. This article analyzes the relationship between historians and the National Truth Commission in Brazil, in addition to the construction of dictatorship public history in the country. In order to do so, the Commission’s relationship with the national community of historians, the works carried out, as well as historians’ reactions towards its works, from its creation until its final report in 2014, will be examined.
Are Certified Supply Chains More Socially Sustainable? A Bargaining Power Analysis
Authors: Muller Paul , Böhm Michael , Csillag Péter , Donati Michele , Drut Marion , Ferrer-Pérez Hugo , Gauvrit Lisa , Gil Jose M. , Hoang Viet , Malak-Rawlikowska Agata , Mattas Konstadinos , Napasintuwong Orachos , Nguyen An , Papadopoulos Ioannis , Ristic Bojan , Stojanovic Zaklina , Török Áron , Tsakiridou Efthimia , Veneziani Mario , Bellassen Valentin 
Published: December 2020

Abstract
Food quality schemes (FQS: organic and geographical indication products) are often supposed to be more sustainable by their political advocates. We explore the social sustainability advantage of FQS through the lens of supply chains’ bargaining power (BP) distribution. We propose an indicator synthesizing different sources underlying BP (competition-based, transactional, institutional) and counting two dimensions (fair BP distribution and adaptation capacity), that we apply to 18 FQS supply chains and corresponding reference. FQS perform better than their reference products on both dimensions. This better performance is due to a combination of sources.