bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed type III hypersensitivity reaction with acute kidney injury in two dogs following administration of concentrated human albumin during treatment for hypoalbuminemia secondary to septic peritonitis
Authors: Mazzaferro Elisa M. , Balakrishnan Anusha , Hackner Susan G. , Forman Marnin , Foster JD , Calabro Janine , Cianciolo Rachel E. 
Published: July 2020

AbstractObjectiveTo describe 2 dogs with acute kidney injury secondary to type III hypersensitivity reaction to 25% human serum albumin (HSA).Case series summaryTwo dogs were presented with evidence of septic peritonitis. The dogs were hospitalized following definitive surgical correction of a jejunal laceration following routine ovariohysterectomy, and removal of a jejunal foreign body. In the postoperative period, both dogs developed hypoalbuminemia and received 25% HSA. At the time of initial discharge, both dogs were doing well clinically and had normal renal parameters. Eleven and 18 days after HSA infusion, respectively, both dogs were re‐presented with clinical signs of inappetence, vomiting, and lameness that progressed to urticaria, peripheral and angioedema, and petechiae, consistent with a delayed type III hypersensitivity reaction. Treatment for the type III hypersensitivity reaction to HSA included administration of diphenhydramine and glucocorticoids. Despite partial resolution of edema and joint swelling, both dogs developed progressive azotemia together with hypoalbuminemia and proteinuria. One dog developed an anuric acute kidney injury (AKI). Both dogs were humanely euthanized. Histopathology of the kidneys of both dogs was consistent with immune complex deposition and vasculitis.New or unique informationSevere type III hypersensitivity reactions have been documented in healthy dogs and clinical patients following the administration of HSA. This report describes the first documented delayed type III hypersensitivity reaction in 2 dogs with septic peritonitis that resulted in AKI, glomerulonephritis, and oligo‐ to anuria in clinical patients following administration of 25% HSA.
COVID‐19 Pandemic – blood supply challenges and approaches in AATM member countries
Authors: Choudhury Nabajyoti , Mathur Ankit , Smit Sibinga Cees Th ,   & On behalf of AATM
Published: July 2020

AbstractWith the COVID‐19 outbreak, AATM took an early initiative to provide the membership instructive recommendations and informative aide mémoire. Optimizing membership support a survey was sent to 25 pandemic affected member countries, to collect challenges and approaches on blood supply and transfusion.ApproachSurvey sent to AATM country representatives. Five questions focused on in‐country blood collection and pandemic situation, diagnosis, treatment and personal protection equipment (PPE), including a snapshot question on disease magnitude; and 2 descriptive questions on challenges and responses to overcome challenges. Country classification – 2018 UNDP statistical update Human Development Indices/Indicators (HDI). Basic metric statistics.ResultsResponse rate: 92%; HDI classification: Low – 1; Medium – 9; High – 9 and Very High – 4 countries; population range: 540 544–1 380 000 000; blood collection/1000: 2·4–36·1. Ranges/1000: hospital beds, intensive care/isolation beds and ventilators respectively: 0·5–8·2; 0·019–1·8; 0·0007–1·11. All countries had quarantine facilities. Sufficient PPE: all but three countries. Testing facilities: all but three countries. All but one country listed challenges and responses. Most common challenges and approaches were, respectively, shortages in blood donors and supply (19/22), staff safety (13/22); and mass media education and awareness campaigns (21/22), staff education on safety practices and universal precautions (18/22).ConclusionHigh response from Medium and High HDI countries. Major challenges reported: effects of pandemic on blood donors and blood supply, where most countries already were suffering from shortages due to their development state. Key approaches: staff education to prevent infection; focused public awareness campaigns to convince donors to keep coming to support the nation’s blood availability during crisis.
Development of an Operational Planning Tool for Geothermal Plants With Heat and Power Production
Authors: Irl Matthäus , Lambert Jerry , Wieland Christoph , Spliethoff Hartmut 
Published: July 2020

Abstract
A short-term operational planning tool for geothermal plants with heat and power production connected to large district heating systems is developed. The software tool contains, among other features, a heat demand forecasting model for district heating systems. Two options, such as linear regression and artificial neural networks, are compared. As the result shows, artificial neural networks with the Bayesian Regularization Backpropagation Algorithm have a high generalization capability and are suitable to forecast the heat demand of large district heating systems with high accuracy. Data from a district heating system with about 70-MW load supplied by a geothermal plant in the south of Munich (Germany) are used for comparison and assessment of all methods. After developing a suitable heat forecast, the heat and power production site is modeled by using mixed-integer linear programming. Mixed-integer linear programming has proven to be a suitable method to model the operation of geothermal plants with heat and power production as well as to solve the planning optimization problem. As the results show, the short-term operational planning tool can optimize the operation of single components as well as of the overall geothermal plant with regard to various objective functions. The tool maximizes the revenues from the sold heat and electricity minus the costs for the boiler fuel and the heat purchased from a connected adjacent geothermal plant. A retro perspective operation investigation has proven that the profitability of the considered geothermal plant could be significantly increased by using the developed software.
Quantitative Assessment of Shoulder Rehabilitation Using Digital Motion Acquisition and Convolutional Neural Network
Authors: Vitali Andrea , Maffioletti Federico , Regazzoni Daniele , Rizzi Caterina 
Published: July 2020

Abstract
Motion capture (Mocap) is applied to motor rehabilitation of patients recovering from a trauma, a surgery, or other impairing conditions. Some rehabilitation exercises are easily tracked with low-cost technologies and a simple Mocap setup, while some others are extremely hard to track because they imply small movements and require high accuracy. In these last cases, the obvious solution is to use high performing motion tracking systems, but these devices are generally too expensive in the rehabilitation context. The aim of this paper is to provide a Mocap solution suitable for any kind of exercise but still based on low-cost sensors. This result can be reached embedding some artificial intelligence (AI), in particular a convolutional neural network (CNN), to gather a better outcome from the optical acquisition. The paper provides a methodology including the way to perform patient's tracking and to elaborate the data from infra-red sensors and from the red, green, blue (RGB) cameras in order to create a user-friendly application for physiotherapists. The approach has been tested with a known complex case concerning the rehabilitation of shoulders. The proposed solution succeeded in detecting small movements and incorrect patient behavior, as for instance, a compensatory elevation of the scapula during the lateral abduction of the arm. The approach evaluated by medical personnel provided good results and encouraged its application in different kinds of rehabilitation practices as well as in different fields where low-cost Mocap could be introduced.
Toward Harmonized Treadmill-Based Validation of Step-Counting Wearable Technologies: A Scoping Review
Authors: Moore Christopher C. , McCullough Aston K. , Aguiar Elroy J. , Ducharme Scott W. , Tudor-Locke Catrine 
Published: July 2020

Background: The authors conducted a scoping review as a first step toward establishing harmonized (ie, consistent and compatible), empirically based best practices for validating step-counting wearable technologies. Purpose: To catalog studies validating step-counting wearable technologies during treadmill ambulation. Methods: The authors searched PubMed and SPORTDiscus in August 2019 to identify treadmill-based validation studies that employed the criterion of directly observed (including video recorded) steps and cataloged study sample characteristics, protocol details, and analytical procedures. Where reported, speed- and wear location–specific mean absolute percentage error (MAPE) values were tabulated. Weighted median MAPE values were calculated by wear location and a 0.2-m/s speed increment. Results: Seventy-seven eligible studies were identified: most had samples averaging 54% (SD = 5%) female and 27 (5) years of age, treadmill protocols consisting of 3 to 5 bouts at speeds of 0.8 (0.1) to 1.6 (0.2) m/s, and reported measures of bias. Eleven studies provided MAPE values at treadmill speeds of 1.1 to 1.8 m/s; their weighted median MAPE values were 7% to 11% for wrist-worn, 1% to 4% for waist-worn, and ≤1% for thigh-worn devices. Conclusions: Despite divergent study methodologies, the authors identified common practices and summarized MAPE values representing device step-count accuracy during treadmill walking. These initial empirical findings should be further refined to ultimately establish harmonized best practices for validating wearable technologies.
What is the Minimum Step Rate Required to Achieve Moderate-Intensity Walking Overground in Adolescent Girls?
Authors: MacDonald Mhairi J. , Fawkner Samantha G. , Niven Ailsa G. 
Published: July 2020

Background: In order to promote walking, researchers have sought to identify the required step rate to maintain a health-enhancing walking intensity However, there is limited evidence regarding the stepping rate required to promote moderate-intensity walking in adolescent girls. Purpose: To identify the step rate equivalent to moderate-intensity physical activity (MPA) in adolescent girls and to explore the influence that different anthropometric measures may have on the step rate equating to MPA in this population. Methods: A total of 56 adolescent girls (mean age = 13.8[0.7] y) were recruited to the study. Anthropometric variables and resting metabolic rate were assessed, followed by 3 overground walking trials on a flat surface at approximately 2, 3, and 4 mph, each lasting a minimum of 4 minutes. Oxygen uptake was assessed using a portable gas analyzer and subsequently converted into metabolic equivalents (METs). Step count was assessed by real-time direct observation hand tally. Results: Employing the linear regression between step rate and METs (r2 = .20, standard error of estimates = 0.003) suggests that 120 steps per minute was representative of an MPA (3 METs) equating to 7200 steps in 60 minutes. Multiple regression and mixed-model regression confirmed weight-related variables and maturity were significant predictors of METs (P < .01). Conclusion: The results suggest that, at population level, a step rate of 120 steps per minute may be advocated to achieve MPA in adolescent girls; although, due to the small sample size used, caution should be applied. At an individual level, other factors, such as age and weight, should be considered.
Effect of water, sanitation and hygiene interventions alone and combined with nutrition on child growth in low and middle income countries: a systematic review and meta-analysis
Authors: Bekele Tolesa , Rawstorne Patrick , Rahman Bayzidur 
Published: July 2020

ObjectiveThis study aimed to provide clarification on the benefits of water, sanitation and hygiene (WASH) alone separately and combined with nutrition in improving child growth outcomes.DesignSystematic review and meta-analysis.MethodsWe conducted a systematic review using the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. PubMed, MEDLINE, EMBASE, Scopus, Cochrane Library, Web of Science and Science Direct were searched in May 2018 and last updated in April 2019. We included studies that reported WASH interventions alone separately or combined with nutrition. Fixed and random-effects models were used to estimate pooled effect in mean difference (MD). Heterogeneity and publication bias statistics were performed.ResultsA total of 18 studies were included: 13 cluster randomised controlled trials (RCTs) and 5 non-randomised controlled trials (non-RCTs). Non-RCTs showed effect of WASH interventions alone on height-for-age z-score (HAZ) (MD=0.14; 95% CI 0.08 to 0.21) but RCTs did not. WASH alone of non-RCTs and RCTs that were delivered over 18–60 months indicated an effect on HAZ (MD=0.04; 95% CI 0.01 to 0.08). RCTs showed an effect for children <2 years (MD=0.07; 95% CI 0.01 to 0.13). Non-RCTs of WASH alone and those that included at least two components, improved HAZ (MD=0.15; 95% CI 0.07 to 0.23) but RCTs did not. WASH alone of non-RCTs and RCTs separately or together showed no effect on weight-for-age z-score (WAZ) and weight-for-height z-score (WHZ). Combined WASH with nutrition showed an effect on HAZ (MD=0.13; 95% CI 0.08 to 0.17) and on WAZ (MD=0.09; 95% CI 0.05 to 0.13) and was borderline on WHZ.ConclusionsWASH interventions alone improved HAZ when delivered over 18–60 months and for children <2 years. Combined WASH with nutrition showed a strong effect on HAZ and WAZ and a borderline effect on WHZ. Integrated WASH with nutrition interventions may be effective inimproving child growth outcomes.
Occupational and environmental risk factors for idiopathic pulmonary fibrosis in Australia: case–control study
Authors: Abramson Michael J , Murambadoro Tsitsi , Alif Sheikh M , Benke Geza P , Dharmage Shyamali C , Glaspole Ian , Hopkins Peter , Hoy Ryan F , Klebe Sonja , Moodley Yuben , Rawson Shuli , Reynolds Paul N , Wolfe Rory , Corte Tamera J , Walters E Haydn 
Published: July 2020

IntroductionIdiopathic pulmonary fibrosis (IPF) is a lung disease of unknown cause characterised by progressive scarring, with limited effective treatment and a median survival of only 2–3 years. Our aim was to identify potential occupational and environmental exposures associated with IPF in Australia.MethodsCases were recruited by the Australian IPF registry. Population-based controls were recruited by random digit dialling, frequency matched on age, sex and state. Participants completed a questionnaire on demographics, smoking, family history, environmental and occupational exposures. Occupational exposure assessment was undertaken with the Finnish Job Exposure Matrix and Australian asbestos JEM. Multivariable logistic regression was used to describe associations with IPF as ORs and 95% CIs, adjusted for age, sex, state and smoking.ResultsWe recruited 503 cases (mean±SD age 71±9 years, 69% male) and 902 controls (71±8 years, 69% male). Ever smoking tobacco was associated with increased risk of IPF: OR 2.20 (95% CI 1.74 to 2.79), but ever using marijuana with reduced risk after adjusting for tobacco: 0.51 (0.33 to 0.78). A family history of pulmonary fibrosis was associated with 12.6-fold (6.52 to 24.2) increased risk of IPF. Occupational exposures to secondhand smoke (OR 2.1; 1.2 to 3.7), respirable dust (OR 1.38; 1.04 to 1.82) and asbestos (OR 1.57; 1.15 to 2.15) were independently associated with increased risk of IPF. However occupational exposures to other specific organic, mineral or metal dusts were not associated with IPF.ConclusionThe burden of IPF could be reduced by intensified tobacco control, occupational dust control measures and elimination of asbestos at work.
Longitudinal evaluation of the impact of standardised packaging and minimum excise tax on tobacco sales and industry revenue in the UK
Authors: Hiscock Rosemary , Augustin Nicole H , Branston J Robert , Gilmore Anna B 
Published: July 2020

BackgroundStandardised packaging for factory-made cigarettes (FM) and roll-your-own tobacco (RYO), and a minimum excise tax (MET) were fully implemented in the UK in May 2017 following a 12-month transition period. This paper is the first to examine effects on tobacco sales volumes and company revenues.MethodsAnalysis of UK commercial supermarket and convenience store electronic point of sale data on tobacco sales. FM and RYO products' data (May 2015–April 2018) yielded 107 572 monthly observations. Expected values from additive mixed modelling were used to calculate trends in: (1) volumes of tobacco sold overall, by cigarette type (FM and RYO) and by seven market segments; and (2) company net revenues. A 10-month period (June 2015–March 2016) before the transition to standardised packs was compared with a 10-month period after the introduction of the MET and full implementation of standardised packs (June 2017–March 2018).ResultsPostimplementation, the average monthly decline in stick sales was 6.4 million (95% CI 0.1 million to 12.7 million) sticks faster than prelegislation, almost doubling the speed of decline. Sales of cheap FM brands, previously increasing, plateaued after implementation. Company monthly net revenues declined from a stable £231 million (95% CI £228 million to £234 million), prelegislation, to £198 million (95% CI £191 million to £206 million) in April 2018.ConclusionsThe concurrent introduction of standardised packaging and MET in the UK was associated with significant decline in sales and in tobacco industry revenues, and the end of the previous growth in cheap cigarette brands that appeal to young and price conscious smokers.
Renormalization of a model for spin-1 matter fields
Authors: Rivero-Acosta Ailier , Vaquera-Araujo Carlos A. 
Published: July 2020

AbstractIn this work, the one-loop renormalization of a theory for fields transforming in the $$(1,0)\oplus (0,1)$$(1,0)⊕(0,1) representation of the Homogeneous Lorentz Group is studied. The model includes an arbitrary gyromagnetic factor and self-interactions of the spin 1 field, which has mass dimension one. The model is shown to be renormalizable for any value of the gyromagnetic factor.
Australian Veterans of the Middle East Conflicts 2001–2010: Select Reproductive Health Outcomes Part 1 — Maternal and Paternal Outcomes
Authors: Warner Rachelle , Avery Jodie C. , Neuhaus Susan , Davies Michael J. 
Published: July 2020

Background: Anecdotally, infertility concerns among serving female Australian Defense Force (ADF) members and veterans are perceived to be prevalent, but precise data are lacking. This is the first of two papers that identify reproductive, pregnancy, and infant outcomes in an exclusively Australian military cohort. This initial paper aims to describe maternal and paternal occupation and fertility characteristics of a group of ADF members who deployed to the Middle East during the period 2001–2010. Methods: Utilizing the Middle East Area of Operations Census Study data set, a descriptive analysis was performed on the demographic and clinical variables of the cohort, where data were reported. Descriptive statistics (means, frequencies, percentiles) were used to describe the population. Sociodemographic data and clinical data, including maternal/paternal outcomes, were reported. Results: The self-reported infertility rate was 9%, which was significantly lower than the reported infertility rate in the comparative Australian (non-military) population. All other outcomes were comparable to the Australian population and within normal limits. Conclusions: This survey presents a generally reassuring picture of reproductive health for men and women serving in the ADF with regard to the risk of infertility, pregnancy loss, and perinatal outcomes, although the basis for fertility concerns requires further investigation.
Monocyte-Derived Leukemia-Associated Macrophages Facilitate Extramedullary Distribution of T-cell Acute Lymphoblastic Leukemia Cells
Authors: Yang Feifei , Feng Wenli , Wang Hao , Wang Lina , Liu Xiaoli , Wang Rong , Chen Chong , Yang Xiao , Zhang Dongyue , Ren Qian , Zheng Guoguang 
Published: July 2020

Abstract

Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activation and functional phenotype. However, their origin and pathologic roles have not been well elucidated. Here we used wild-type and CCR2−/− mice to study the pathologic roles of monocyte-derived LAM in extramedullary tissues in models of Notch1-induced T-cell acute lymphoblastic leukemia (T-ALL). MOMF existed in the resting liver and spleen. In the spleen, Ly6C+ monocytes gave rise to the Ly6C+ macrophage subset. Furthermore, an increase of monocyte-derived LAM, including the Ly6C+ subset, was detected in the extramedullary tissues in leukemic mice. More monocyte-derived LAM, including Ly6C+ LAM, was detected in the spleens of leukemic mice transplanted with exogeneous mononuclear cells. Moreover, Ly6C+ LAM exhibited increased M1-related characteristics and contributed to sterile inflammation. In CCR2−/− leukemic mice, reduced Ly6C+ LAM, relieved sterile inflammation, and reduced distribution of leukemia cells were detected in extramedullary tissues. In addition, monocyte-derived Ly6C+ LAM expressed high levels of CCL8 and CCL9/10. Blocking CCR1 and CCR2 relieved hepatosplenomegaly and inhibited the extramedullary distribution of leukemia cells in T-ALL mice. Collectively, our findings reveal the multifaceted pathologic roles of monocyte-derived LAM in T-ALL progression.

Significance:
This study links monocyte-derived leukemia-associated macrophages with noninfectious inflammation and extramedullary distribution of leukemia cells during leukemia progression, providing new insight into macrophage-based immunotherapy in leukemia.
Distinctions with a Difference: RNA Subtyping and Clinical Outcome in Pancreatic Cancer
Authors: Collisson Eric A. 
Published: July 2020

Abstract
Pancreatic cancer patients are in desperate need of effective therapy virtually from the moment of their diagnosis. As we acquire more therapies, how best to deploy them, in what order and to which patients is emerging as an important clinical question. Pancreatic cancer subtypes, identifiable with common lab diagnostics in diagnostic biopsy samples, may be helpful in guiding therapy selection.
See related article by O'Kane et al., p. 4901