bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mahara como red social y portafolio digital en los nuevos contextos de formación inicial docente. Un estudio de casos
Authors: Muñoz González Laura de la Concepción , Soto Gómez Encarna 
Published: March 2020

El objetivo de esta investigación es comprender las virtualidades y limitaciones de la red social y portafolio digital Mahara en la formación inicial docente. En los últimos años, los medios digitales, entre los que destacan las redes sociales, han incrementado su influencia en los distintos ámbitos de la vida cotidiana. Las aulas, ocupadas ya por nativos digitales, ponen de manifiesto la necesidad de incorporar en la educación herramientas que permitan transferir las funcionalidades que tanto nos atraen de las redes sociales (interactividad, sociabilidad, facilidad para crear espacios de intimidad, personalización y acceso a información ilimitada) al ámbito académico, especialmente en la formación del profesorado novel. Mahara parece favorecer el desarrollo de competencias docentes a través de la integración de lo formal y lo social. En este sentido, se ha llevado a cabo un estudio de casos conformado por un grupo de estudiantes de Educación Infantil de la Universidad de Málaga y su profesorado, quienes utilizan Mahara en varias asignaturas. El análisis y triangulación de los datos dio lugar a siete categorías emergentes que nos permiten conocer mejor las potencialidades y desafíos de la herramienta a través de la singularidad de lo que podría considerarse como una buena experiencia formativa.
The objective of this research is to understand the virtualities and limitations of the Mahara social network and digital portfolio in initial teacher training. In recent years, digital media, among which social networks stand out, have increased their influence in different areas of daily life. The classrooms, already occupied by digital natives, highlight the need to incorporate into education tools that allow transferring the functionalities that attract us so much from social networks (interactivity, sociability, ease to create spaces of intimacy, personalization and access to information unlimited) to the academic field, especially in the training of new teachers. Mahara seems to favor the development of teaching competencies through the integration of the formal and the social. In this sense, a case study has been carried out consisting of a group of students of Early Childhood Education of the University of Malaga and its teaching staff, who use Mahara in various subjects. The analysis and triangulation of the data gave rise to seven emerging categories that allow us to better understand the potential and challenges of the tool through the uniqueness of what could be considered as a good teacher training experience.
Percepciones de estudiantes y docentes del uso que los estudiantes hacen de Internet y su relación con la modalidad de estudio
Authors: Valencia-Ortiz Rubicelia , Garay Urtza , Cabero-Almenara Julio 
Published: March 2020

Internet y las redes sociales se han convertido en las tecnologías estrella entre los estudiantes actuales. En cambio, todavía hay pocos estudios sobre el uso y percepción que el alumnado hace de ellas. Incluso, es difícil encontrar comparaciones entre las percepciones sobre el uso que realizan los estudiantes desde el punto de vista del profesorado y del mismo alumnado. El objetivo de este trabajo es profundizar en las diferencias entre las percepciones del profesorado y los estudiantes respecto a los usos de internet y redes sociales que estos últimos realizan. La muestra está conformada por 17 600 alumnos y 1 498 docentes de la Ciudad de México. Se realizó un estudio exploratorio y ex post-facto, mediante el instrumento de recogida de datos “Social Media Addiction Scale-Studen Form”. Entre los resultados destaca la diferencia entre la percepción de uso que presenta el alumnado y la que tiene el profesorado. Además, son los estudiantes que cursan sus estudios a distancia los que más utilizan las redes para su proceso de aprendizaje. Estos resultados sugieren la necesidad de tomar medidas educativas para intensificar el uso formativo de internet y las redes sociales entre el alumnado.
Internet and social media have become so trend tech activity among the current students. On the other hand, there are still few studies about the usage and the perceptions students have about them. It is even harder to find some comparisons between the perception of the students and the professors in this topic. The purpose of this work is to deepen into the existent differences between the students and teachers perceptions referred to the Internet and social media usage. The sample gathered 17600 students and 1498 teachers within Mexico City. The study was made to explore and post-facto as well, using data form from "Social Media Addiction Scale-Student Form". The results emphasized the difference between the perception of usage for students and for teachers. Students who work their curricula on line, use the internet for their learning process. These results suggest the need to apply educative dictations to intensify the formative use of internet and social media in the student´s environment.
OD
Authors: Campbell Nancy D. 
Published: March 2020

The history of an unnatural disaster—drug overdose—and the emergence of naloxone as a social and technological solution.
For years, drug overdose was unmentionable in polite society. OD was understood to be something that took place in dark alleys—an ugly death awaiting social deviants—neither scientifically nor clinically interesting. But over the last several years, overdose prevention has become the unlikely object of a social movement, powered by the miracle drug naloxone. In OD, Nancy Campbell charts the emergence of naloxone as a technological fix for overdose and describes the remaking of overdose into an experience recognized as common, predictable, patterned—and, above all, preventable. Naloxone, which made resuscitation, rescue, and “reversal” after an overdose possible, became a tool for shifting law, policy, clinical medicine, and science toward harm reduction. Liberated from emergency room protocols and distributed in take-home kits to non-medical professionals, it also became a tool of empowerment.
After recounting the prehistory of naloxone—the early treatment of OD as a problem of poisoning, the development of nalorphine (naloxone's predecessor), the idea of “reanimatology”—Campbell describes how naloxone emerged as a tool of harm reduction. She reports on naloxone use in far-flung locations that include post-Thatcherite Britain, rural New Mexico, and cities and towns in Massachusetts. Drawing on interviews with approximately sixty advocates, drug users, former users, friends, families, witnesses, clinicians, and scientists—whom she calls the “protagonists” of her story—Campbell tells a story of saving lives amid the complex, difficult conditions of an unfolding unnatural disaster.
Cycloaddition Reactions of Alkene Radical Cations using Iron(III)‐Phenanthroline Complex
Authors: Cho Yong Hyun , Kim Jae Hyung , An Hyeju , Ahn Kwang‐Hyun , Kang Eun Joo 
Published: March 2020

AbstractSingle electron oxidation of electron‐rich alkenes using the iron(III)‐phenanthroline complex produced electrophilic alkene radical cations, which promoted efficient radical cation [2+1] cycloaddition reactions with diazo compounds. Subsequent chain propagation afforded tri‐ and tetra‐substituted cyclopropanes. This methodology was also expanded to [3+2] cycloaddition reactions with vinyl diazoesters, validating this sustainable, first‐row transition metal iron system for the single electron redox reactions.magnified image
Synthesis of 1,4‐Benzothiazines via KI/DMSO/O2‐Mediated Three‐Component Oxidative Cyclization/Coupling
Authors: Zhao Jinwu , Luo Zhigao , Xu Jingxiu 
Published: March 2020

AbstractA three‐component transition‐metal‐free aerobic method for the generation of 1,4‐benzothiazines is reported herein. The KI/DMSO/O2 system was found to be effective for the oxidative cyclization/coupling of 2‐aminobenzenethiols, anilines, and methylketones. Hence, various structurally important imino 1,4‐benzothiazines were assembled with broad functional group tolerance. Mechanistic studies revealed an initial oxidation of ketone α C−H bonds by the KI/DMSO/O2 oxidative system.magnified image
Prognostic impact of p53 and/or NY‐ESO‐1 autoantibody induction in patients with gastroenterological cancers
Authors: Hoshino Isamu , Nabeya Yoshihiro , Takiguchi Nobuhiro , Gunji Hisashi , Ishige Fumitaka , Iwatate Yosuke , Shiratori Fumiaki , Yajima Satoshi , Okada Rei , Shimada Hideaki 
Published: March 2020

AbstractBackground and AimWe evaluated the clinicopathological and prognostic significance of serum p53 (s‐p53‐Abs) and serum NY‐ESO‐1 autoantibodies (s‐NY‐ESO‐1‐Abs) in esophageal squamous cell carcinoma (ESCC), gastric cancer and hepatocellular carcinoma (HCC).Patients and MethodsA total of 377 patients, 85 patients with ESCC, 248 patients with gastric cancer, and 44 patients with HCC were enrolled to measure s‐p53‐Abs and s‐NY‐ESO‐1‐Abs titers by the enzyme‐linked immunosorbent assay before treatment. The clinicopathological significance and prognostic impact of the presence of autoantibodies were evaluated. Expression data based on the Cancer Genome Atlas and the prognostic impact of gene expression was also examined for discussion.ResultsThe positive rates of s‐p53‐Abs were 32.9% in ESCC, 15% in gastric cancer, and 4.5% in HCC. The positive rates of s‐NY‐ESO‐1‐Abs were 29.4% in ESCC, 9.7% in gastric cancer, and 13.6% in HCC. The presence of s‐p53‐Abs was not associated with tumor progression in these three cancer types. On the other hand, the presence of s‐NY‐ESO‐1‐Abs was significantly associated with tumor progression in ESCC and gastric cancer. The presence of s‐p53‐Abs and/or s‐NY‐ESO‐1‐Abs was significantly associated with poor prognosis in gastric cancer but not in ESCC nor HCC.ConclusionsThe presence of s‐p53‐Abs and/or s‐NY‐ESO‐1‐Abs was associated with tumor progression in ESCC and gastric cancer. These autoantibodies might have poor prognostic impacts on gastric cancer (UMIN000014530).
Quantitative distinction of thermodynamic soluble and miscible states
Authors: Zhang Kaiqiang , Jia Na , Liu Lirong 
Published: March 2020

AbstractSoluble and miscible states are two important thermodynamic states in academic research and practical applications but their quantitative distinctions are still fuzzy. In this study, for the first time, the mathematical formulations of the quantitative criteria for distinguishing the thermodynamic soluble and miscible states are analytically developed by means of the Flory–Huggins solution theory and solubility parameter. The quantitative bottom and upper solubility limits for a total of 13 binary and ternary mixtures are calculated at different conditions. Moreover, the composition, temperature and pore radius are specifically studied to evaluate their effects on the soluble and miscible states. On the basis of the work from this study, the insoluble, soluble but immiscible, and miscible states are definitively quantified and clearly distinguished for the first time.
Health related quality of life varies by weight loss method in patients with history of nonalcoholic fatty liver disease
Authors: Bellavance Danielle , Halegoua‐Demarzio Dina 
Published: March 2020

AbstractWeight loss through lifestyle modification is currently the standard of care in the management of patients with nonalcoholic fatty liver disease (NAFLD); however, benefits of specific strategies for achieving weight loss in these patients are poorly understood. We sought to determine whether patient satisfaction and health‐related quality of life (HRQoL) vary by specific weight loss method in patients with NAFLD. Patients diagnosed with NAFLD in the previous 6 months to 3 years were identified through chart review at our urban, tertiary medical center. Participants were administered an online questionnaire assessing liver disease and weight loss history, HRQoL, and satisfaction with their weight loss method. Patients who incorporated caloric restriction into their weight loss plans had lower total HRQoL scores (5.0 vs 5.4, P = .05) as compared to patients who did not include this method. Multivariate analysis showed that caloric restriction was independently associated with lower HRQoL scores (β = −2.25, P = .03). Weight loss was associated with both increased total HRQoL scores (5.3 vs 4.9, P = .05) and increased patient satisfaction scores (3.3 vs 2.1, P = 4.00 × 10−10). Our data demonstrate that incorporation of caloric restriction into a weight loss plan is associated with lower HRQoL. Choosing a weight loss strategy associated with improved quality of life could be an important factor in improving adherence and patient outcomes.
Synthese eines gegenanionstabilisierten Bis(silylium)ions
Authors: Wu Qian , Roy Avijit , Wang Guoqiang , Irran Elisabeth , Klare Hendrik F. T. , Oestreich Martin 
Published: March 2020

AbstractEs wird über die Darstellung eines Moleküls mit zwei alkylverknüpften Silyliumionzentren ausgehend vom entsprechenden Bis(hydrosilan) mittels zweifacher Hydridabstraktion berichtet. Die Länge der konformativ flexiblen Alkylbrücke ist entscheidend, denn sonst bleibt die Hydridabstraktion auf der Stufe eines cyclischen bissilylierten Hydroniumions stehen. Für den Fall einer Ethylenbrücke ist die offene Form der Hydroniumionzwischenstufe energetisch zugänglich und geht eine weitere Hydridabstraktion ein. Das daraus hervorgehende Bis(silylium)ion wurde NMR‐spektroskopisch und strukturell charakterisiert. Verwandte Systeme auf der Grundlage von starren Naphthalen‐n,m‐diylplattformen können nur dann in die Dikationen überführt werden, wenn die positiv geladenen Silyliumioneinheiten voneinander entfernt sind (1,8 gegenüber 1,5 und 2,6).
Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow
Authors: Harenberg Johannes H. , Weidmann Niels , Knochel Paul 
Published: March 2020

AbstractWe report the preparation of lithium‐salt‐free KDA (potassium diisopropylamide; 0.6 m in hexane) complexed with TMEDA (N,N,N′,N′‐tetramethylethylenediamine) and its use for the flow‐metalation of (hetero)arenes between −78 °C and 25 °C with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min−1 using a commercial flow setup. The resulting potassium organometallics react instantaneously with various electrophiles, such as ketones, aldehydes, alkyl and allylic halides, disulfides, Weinreb amides, and Me3SiCl, affording functionalized (hetero)arenes in high yields. This flow procedure is successfully extended to the lateral metalation of methyl‐substituted arenes and heteroaromatics, resulting in the formation of various benzylic potassium organometallics. A metalation scale‐up was possible without further optimization.
Position and feedback for digital microfluidic system based on light intensity information
Authors: Luo Zhijie , Fan Junjun , Huang Bangrui , Liu Shuangyin , Dai Feng 
Published: March 2020

AbstractThe digital microfluidic system based on electrowetting on dielectric is a new technology that can control microliter droplets within the plane. Because of layout, fabrication, and driving uncertainties, feedback control schemes must be designed and implemented to ensure safety and reliability of digital microfluidic system for practical application. The basis for feedback is to realize the accurate droplet location. So, there is a strong need for the development of a digital microfluidic system integrated with position and feedback scheme for innovative biological research. In this paper, we propose a position and feedback scheme based on light intensity for digital microfluidic system. The verified experiment results show that the proposed position and feedback scheme can position multiple droplets accurately and improve the success rate of droplets transport application by feedback.
Cultural determinants in Winnicott's developmental theories
Authors: Dajani Karim G. 
Published: March 2020

AbstractThis article applies a cultural or collective perspective to Winnicott's developmental theories. Expanding on existing psychoanalytic literature and drawing from neighboring fields, specifically the work of the French sociologist and anthropologist Pierre Bourdieu, the notion of habitus is utilized to account for the constitutive impact of culture or a collective on individual development. Cultural systems play a fundamental role in the structuring of subjectivity and the coordination of inter‐subjective linking. Collective systems of meaning‐making (cultures) replicate themselves in the minds of individuals who are structured by them. Extending this idea to Winnicott's developmental theories will help illuminate the constitutive impact of Winnicott's cultures or collectives on his perception, thinking and theories. A case example illustrating the thesis of cultures’ constitutive impact on an individual's basic experience of self and world is provided.
Synergistic Assembly of a CoS@NiFe/Ni Foam Heterostructure Electrocatalyst for Efficient Water Oxidation Catalysis at Large Current Densities
Authors: Wang Muheng , Wu Yun , Li Na , Zhao Fei , Zhao Qiang , Li Jinping , Liu Guang 
Published: March 2020

AbstractElectrochemical water splitting is an ideal pollution‐free path to generate hydrogen at large scale, however, the development of highly catalytic electrocatalysts for the water oxidation reaction at large current densities is still a fundamental challenge. Herein, we report a novel, high‐wettability water‐oxidation electrocatalyst composed of an amorphous NiFe layer and CoS film on commercial nickel foam via a two‐step electrodeposition synthetic path. Benefiting from the strong interactions between the NiFe layer and CoS film, enlarged surface active sites and enhanced wettability, the CoS@NiFe/NF electrode exhibited an outstanding water oxidation performance at 10 mA/cm2 with an overpotential of 175 mV in 1 M KOH solution and steadily delivered a current density of 1 A/cm2 at merely 330 mV in 30 wt% KOH solution. Even at large densities, the CoS@NiFe/NF hybrids also showed excellent water oxidation stability and corrosion resistance for at least 24 h. Such a synergistic assembling approach to fabricate a CoS@NiFe/NF heterostructure together with excellent OER performance may be a promising strategy for rationally building and designing heterostructural electrocatalysts towards highly efficient water oxidation reaction.
meso‐Free BIII Subporphyrins with Electron‐donating Groups
Authors: Bekki Yosuke , Osuka Atsuhiro 
Published: March 2020

Abstractmeso‐Free BIII 5,10‐bis(p‐dimethylaminophenyl)subporphyrins were synthesized. They display red‐shifted absorption and fluorescence spectra, bathochromic behaviors in polar solvents, a high fluorescence quantum yield (ΦF=0.57), and a small HOMO–LUMO gap mainly due to destabilized HOMO as compared with meso‐free BIII 5,10‐diphenylsubporphyrin. This subporphyrin serves as a nice precursor of various meso‐substituted BIII subporphyrins such as BIII meso‐nitrosubporphyrin, BIII meso‐aminosubporphyrin, and meso‐meso’ linked BIII azosubporphyrin dimer. Reactions of meso‐free BIII subporphyrins with NBS or bis(2,4,6‐trimethylpyridine)bromonium hexafluorophosphate gave meso‐meso′ linked subporphyrin dimers, often as a major product along with meso‐bromosubporphyrins.
Lost in translation: “Risks,” “needs,” and “evidence” in implementing the First Step Act
Authors: Skeem Jennifer , Monahan John 
Published: March 2020

AbstractIn this article, we focus on two highly problematic issues in the manner in which the First Step Act of 2018 is being implemented by the Bureau of Prisons: an uncritical separation of “dynamic risks” and “criminogenic needs”; and a spurious reliance on “evidence‐based” interventions to reduce recidivism risk. We argue that if the Act is to live up to its promise of being a game‐changing development in efforts to reduce crime while simultaneously shrinking mass incarceration, “needs assessment” must be subject to vastly increased empirical attention, variable and causal risk factors must be identified and validly assessed, and interventions to reduce risk must be rigorously evaluated both for their fidelity of implementation and impact on recidivism. Rather than further proliferating programs that ostensibly reduce risk, we believe that serious consideration should be given to the Bureau of Prisons offering one signature, well‐established cognitive‐behavioral program that can simultaneously address multiple risk factors for moderate and high‐risk prisoners.
Long‐term results of vascularized proximal fibula epiphyseal transfer based on the anterior tibial artery in retrograde fashion
Authors: Ishiura Ryohei , Sawaizumi Masayuki 
Published: March 2020

AbstractInjury of bone growth plates can result in severe disability in children. We report the long‐term results of successful vascularized proximal fibula epiphyseal transfer based on the anterior tibial artery in retrograde fashion.
Distannabarrelenes with Three Coordinated SnII Atoms
Authors: Sharma Mahendra K. , Glodde Timo , Neumann Beate , Stammler Hans‐Georg , Ghadwal Rajendra S. 
Published: March 2020

AbstractCrystalline 1,4‐distannabarrelene compounds [(ADCAr)3Sn2]SnCl3 (3‐Ar) (ADCAr={ArC(NDipp)2CC}; Dipp=2,6‐iPr2C6H3, Ar=Ph or DMP; DMP=4‐Me2NC6H4) derived from anionic dicarbenes Li(ADCAr) (2‐Ar) (Ar=Ph or DMP) have been reported. The cationic moiety of 3‐Ar features a barrelene framework with three coordinated SnII atoms at the 1,4‐positions, whereas the anionic unit SnCl3 is formally derived from SnCl2 and chloride ion. The all carbon substituted bis‐stannylenes 3‐Ar have been characterized by NMR spectroscopy and X‐ray diffraction. DFT calculations reveal that the HOMO of 3‐Ph (ϵ=−6.40 eV) is mainly the lone‐pair orbital at the SnII atoms of the barrelene unit. 3‐Ar readily react with sulfur and selenium to afford the mixed‐valence SnII/SnIV compounds [(ADCAr)3SnSn(E)](SnCl6)0.5 (E=S 4‐Ar, Ar=Ph or DMP; E=Se 5‐Ph).
Ruthenium‐Catalyzed Site‐Selective Trifluoromethylations and (Per)Fluoroalkylations of Anilines and Indoles
Authors: Li Yang , Neumann Helfried , Beller Matthias 
Published: March 2020

AbstractIntroducing (per)fluoroalkyl groups into arenes continues to be an interesting, but challenging area in organofluorine chemistry. We herein report an ortho‐selective C−H perfluoroalkylation including trifluoromethylations of anilines and indoles without the need of protecting groups using RfI and RfBr as commercially available reagents. The availability and price of the starting materials and the inherent selectivity make this novel methodology attractive for the synthesis of diverse (per)fluoroalkylated building blocks, for example, for bioactive compounds and materials.
RhodiumIII/SilverI Relay Catalyzed C—H Aminomethylation with Imine Equivalents and Lewis Acid Catalyzed [4+2] Cycloaddition of Indoles with Triarylhexahydrotriazine†
Authors: Liu Ruixing , Wei Yin , Shi Min 
Published: March 2020

Summary of main observation and conclusionA RhIII/AgI relay‐catalyzed C(sp2)—H coupling of indoles with triarylhexahydrotriazine (THT) is reported in this context. Upon merging RhIII‐catalyzed C(sp2)—H bond activation and silver promoted THT dissociation, an efficient indole's C3 aminomethylation protocol is uncovered, providing C3 aminomethyl indoles in good yields and exhibiting potential applications for the synthesis of complicated bioactive compounds. We revealed the C3‐selectivity of this reaction through a detailed mechanistic investigation. Meanwhile, during the examination of the reaction conditions, we discovered another [4+2] cycloaddition pathway to afford tetrahydro‐indolo[3,2‐c]quinoline scaffold products via silver or Lewis acid catalysis.