bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial
Authors: Serfaty Marc , Aspden Trefor , Satchell Jessica , Kessel Anthony , Laycock Gloria , Brewin Chris R. , Buszewicz Marta , O’Keeffe Aidan , Hunter Rachael , Leavey Gerard , Cuming-Higgs Jon , Drennan Vari , Riveros Monica , Andrew David , Blanchard Martin 
Published: April 2020

Abstract
Background
Older people are vulnerable to sustained high levels of psychosocial distress following a crime. A cognitive behavioural therapy (CBT)-informed psychological therapy, the Victim Improvement Package (VIP) may aid recovery. The VIP trial aims to test the clinical and cost-effectiveness of the VIP for alleviating depressive and anxiety symptoms in older victims of crime.

Methods/design
People aged 65 years or more who report being a victim of crime will be screened by Metropolitan Police Service Safer Neighbourhood Teams within a month of the crime for distress using the Patient Health Questionnaire-2 and the Generalised Anxiety Disorder-2. Those who screen positive will be signposted to their GP for assistance, and re-screened at 3 months. Participants who screen positive for depression and/or anxiety at re-screening are randomised to a CBT informed VIP added to treatment as usual (TAU) compared to TAU alone. The intervention consists of 10 individual 1-h sessions, delivered weekly by therapists from the mental health charity Mind.
The primary outcome measure is the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI), used as a composite measure, assessed at 6 months after the crime (post therapy) with a 9-month post-crime follow-up. Secondary outcome measures include the EQ-5D, and a modified Client Service Receipt Inventory. A total of 226 participants will be randomised VIP:TAU with a ratio 1:1, in order to detect a standardised difference of at least 0.5 between groups, using a mixed-effects linear-regression model with 90% power and a 5% significance level (adjusting for therapist clustering and potential drop-out).
A cost-effectiveness analysis will incorporate intervention costs to compare overall health care costs and quality of life years between treatment arms. An embedded study will examine the impact of past trauma and engagement in safety behaviours and distress on the main outcomes.

Discussion
This trial should provide data on the clinical and cost-effectiveness of a CBT-informed psychological therapy for older victims of crime with anxiety and/or depressive symptoms and should demonstrate a model of integrated cross-agency working. Our findings should provide evidence for policy-makers, commissioners and clinicians responding to the needs of older victims of crime.

Trial registration
International Standard Randomised Controlled Trials Number, ID: ISRCTN16929670. Registered on 3 August 2016.
Carotenoids and lipid production from Rhodosporidium toruloides cultured in tea waste hydrolysate
Authors: Qi Feng , Shen Peijie , Hu Rongfei , Xue Ting , Jiang Xianzhang , Qin Lina , Chen Youqiang , Huang Jianzhong 
Published: April 2020

Abstract
Background
In this study, renewable tea waste hydrolysate was used as a sole carbon source for carotenoids and lipid production. A novel Rhodosporidium toruloides mutant strain, RM18, was isolated through atmospheric and room-temperature plasma mutagenesis and continuous domestication in tea waste hydrolysate from R. toruloides ACCC20341.

Results
RM18 produced a larger biomass and more carotenoids and α-linolenic acid compared with the control strain cultured in tea waste hydrolysate. The highest yields of torularhodin (481.92 μg/g DCW) and torulene (501 μg/g DCW) from RM18 cultured in tea waste hydrolysate were 12.86- and 1.5-fold higher, respectively, than that of the control strain. In addition, α-linolenic acid production from RM18 in TWH accounted for 5.5% of total lipids, which was 1.58 times more than that of the control strain. Transcriptomic profiling indicated that enhanced central metabolism and terpene biosynthesis led to improved carotenoids production, whereas aromatic amino acid synthesis and DNA damage checkpoint and sensing were probably relevant to tea waste hydrolysate tolerance.

Conclusion
Tea waste is suitable for the hydrolysis of microbial cell culture mediums. The R. toruloides mutant RM18 showed considerable carotenoids and lipid production cultured in tea waste hydrolysate, which makes it viable for industrial applications.
Cognitive dysfunction in autoimmune rheumatic diseases
Authors: Oláh Csaba , Schwartz Noa , Denton Christopher , Kardos Zsófia , Putterman Chaim , Szekanecz Zoltán 
Published: April 2020

AbstractFor people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.
Tablet vs. station-based laptop ultrasound devices increases internal medicine resident point-of-care ultrasound performance: a prospective cohort study
Authors: Glogoza Matt , Urbach Jonathan , Rosborough Terry K. , Olet Susan , St. Hill Catherine A. , Smith Claire S. , Tierney David M. 
Published: April 2020

Abstract
Background
Point-of-care ultrasound (POCUS) is becoming an important part of internal medicine (IM) residency training. Achieving competency requires performing a large volume of clinical exams which can be difficult within the constraints of residency. Often-cited barriers include insufficient resident time and the interruption of daily workflow. Despite availability of hospital station-based laptop ultrasound machines, we hypothesized that the addition of ward team-based tablet ultrasound devices would lower barriers and increase clinical POCUS volume within an IM residency POCUS curriculum at a 670-bed, quaternary care, teaching hospital. IM resident POCUS volumes and characteristics during an 18-mo. baseline (station-based laptop devices only) period were compared to matched months during the intervention (station-based + tablet).

Results
Total patients examined with POCUS by 6 inpatient resident teams during the 18-mo. baseline and intervention periods were 1386 and 1853, respectively. Patients examined per month increased during the intervention by 34% (77 vs. 103, p = 0.002). The number of areas (e.g., abdominal, cardiac) and items (e.g., bladder, pericardial effusion) examined per month increased by 27% (p = 0.021) and 23% (p = 0.073), respectively.

Conclusions
A combined program infrastructure of station-based laptop and “in-the-pocket” tablet ultrasound devices lowered common POCUS barriers of inadequate time and workflow disruption for IM residents and resulted in a meaningful increase of exams within a longitudinal residency-based training program where station-based laptop devices already existed.
BMPR-1B, BMP-15 and GDF-9 genes structure and their relationship with litter size in six sheep breeds reared in Egypt
Authors: Saleh Ahmed. A. , Hammoud M. H. , Dabour Nasraa A. , Hafez E. E. , Sharaby Mahmoud A. 
Published: April 2020

Abstract
Objective
The aim of this work was to investigate three different mutations; Fec-B, FecXG, Fec-GH at three candidate genes; Bone morphogenetic protein receptor IB, Bone morphogenetic protein 15 and Growth Differentiation Factor 9, respectively, in six sheep breeds reared in Egypt namely; Rahmani, Barki, Rahmani X Barki cross, Awassi, Awassi X Suffolk cross, and Ossimi and their association with litter size.

Results
Genomic DNA of 132 sheep was investigated for the Fec-B, FecXG, and Fec-GH mutations by Restriction Fragment Length Polymorphism, Single-Stranded Conformation Polymorphism and DNA sequencing. The results revealed that all breeds did not carry Fec-B mutation. On the other side, the mutations of FecXG, and Fec-GH were detected in Rahmani, and Rahmani X Barki cross which is associated with the high twinning rate/litter size of Rahmani (1.28) and Rahmani X Barki cross (1.22). While, the average litter size for other breeds had almost a constant values rate over six parities, ranging between 1.00 and 1.04.
Energy-dense nutrient-poor snacks and risk of non-alcoholic fattyliver disease: a case–control study in Iran
Authors: Yari Zahra , Cheraghpour Makan , Aghamohammadi Vahideh , Alipour Meysam , Ghanei Nila , Hekmatdoost Azita 
Published: April 2020

Abstract
Objective
The purpose of the present study was to determine the association between energy-dense nutrient-poor snacks intake and the risk of non-alcoholic fatty liver disease (NAFLD) in Iranian adults. For this purpose, a total of 143 cases with a newly confirmed diagnosis of NAFLD and 471 controls free of the disease were studied. Dietary intake was assessed using a food frequency questionnaire.

Results
The percentage of calories from total energy-dense nutrient-poor snacks was 6.08% and 5.04%, in patients and controls, respectively (P = 0.036). Compared with subjects in the lowest quartile of total energy-dense nutrient-poor snacks intake, the risk of NAFLD for those in the top quartile of consumption increased by about two times, in both crude (OR: 1.94; 95% CIs 1.16–3.26; P for trend = 0.015) and adjusted (OR: 2.27; 95%CIs 1.19–4.31; P for trend = 0.001) models. The relative odds of NAFLD increased significantly in the fourth quartile of dietary cake and biscuit (OR: 1.21, P for trend = 0.037) and soft drinks (OR: 1.64, P for trend = 0.005) intake compared with the lowest corresponding quartiles, after adjustment for age, sex, body mass index, physical activity, alcohol, energy intake. Our results indicate that there might be a moderate positive association between energy-dense nutrient-poor snacks intake and risk of NAFLD.
Human in vitro models for understanding mechanisms of autism spectrum disorder
Authors: Gordon Aaron , Geschwind Daniel H. 
Published: April 2020

AbstractEarly brain development is a critical epoch for the development of autism spectrum disorder (ASD). In vivo animal models have, until recently, been the principal tool used to study early brain development and the changes occurring in neurodevelopmental disorders such as ASD. In vitro models of brain development represent a significant advance in the field. Here, we review the main methods available to study human brain development in vitro and the applications of these models for studying ASD and other psychiatric disorders. We discuss the main findings from stem cell models to date focusing on cell cycle and proliferation, cell death, cell differentiation and maturation, and neuronal signaling and synaptic stimuli. To be able to generalize the results from these studies, we propose a framework of experimental design and power considerations for using in vitro models to study ASD. These include both technical issues such as reproducibility and power analysis and conceptual issues such as the brain region and cell types being modeled.
GVHD-derived plasma as a priming strategy of mesenchymal stem cells
Authors: Silva-Carvalho Amandda Évelin , Rodrigues Leane Perim , Schiavinato Josiane Lilian , Alborghetti Marcos Rodrigo , Bettarello Gustavo , Simões Belinda Pinto , Neves Francisco de Assis Rocha , Panepucci Rodrigo Alexandre , de Carvalho Juliana Lott , Saldanha-Araujo Felipe 
Published: April 2020

Abstract
Background
Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of MSCs constitute an active area of investigation. Here, we proposed an innovative priming strategy based on the plasma obtained from GVHD patients and tested whether this approach could enhance the immunosuppressive capacity of MSCs.

Methods
We obtained the plasma from healthy as well as acute (aGVHD) and chronic (cGVHD) GVHD donors. Plasma samples were characterized according to the TNF-α, IFN-γ, IL-10, IL-1β, IL-12p40, and IL-15 cytokine levels. The MSCs primed with such plasmas were investigated according to surface markers, morphology, proliferation, mRNA expression, and the capacity to control T cell proliferation and Treg generation.

Results
Interestingly, 57% of aGVHD and 33% of cGVHD plasmas significantly enhanced the immunosuppressive potential of MSCs. The most suppressive MSCs presented altered morphology, and those primed with cGHVD displayed a pronounced overexpression of ICAM-1 on their surface. Furthermore, we observed that the ratio of IFN-γ to IL-10 cytokine levels in the plasma used for MSC priming was significantly correlated with higher suppressive potential and Treg generation induction by primed MSCs, regardless of the clinical status of the donor.

Conclusions
This work constitutes an important proof of concept which demonstrates that it is possible to prime MSCs with biological material and also that the cytokine levels in the plasma may affect the MSC immunosuppressive potential, serving as the basis for the development of new therapeutic approaches for the treatment of immune diseases.
A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by 18F-positron emitting tomography and fluorescence
Authors: Guo Hua , Kommidi Harikrishna , Lekaye Carl C. , Koutcher Jason , Judenhofer Martin S. , Cherry Simon R. , Wu Amy P. , Akin Oguz , Souweidane Mark M. , Aras Omer , Zhu Zhaohui , Ting Richard 
Published: April 2020

Abstract
Purpose
Knowing the precise flow of cerebrospinal fluid (CSF) is important in the management of multiple neurological diseases. Technology for non-invasively quantifying CSF flow would allow for precise localization of injury and assist in evaluating the viability of certain devices placed in the central nervous system (CNS).

Methods
We describe a near-infrared fluorescent dye for accurately monitoring CSF flow by positron emission tomography (PET) and fluorescence. IR-783, a commercially available near-infrared dye, was chemically modified and radiolabeled with fluorine-18 to give [18F]-IR783-AMBF3. [18F]-IR783-AMBF3 was intrathecally injected into the rat models with normal and aberrant CSF flow and evaluated by the fluorescence and PET/MRI or PET/CT imaging modes.

Results
IR783-AMBF3 was clearly distributed in CSF-containing volumes by PET and fluorescence. We compared IR783-AMBF3 (fluorescent at 778/793 nm, ex/em) to a shorter-wavelength, fluorescein equivalent (fluorescent at 495/511 nm, ex/em). IR783-AMBF3 was superior for its ability to image through blood (hemorrhage) and for imaging CSF-flow, through-skin, in subdural-run lumboperitoneal shunts. IR783-AMBF3 was safe under the tested dosage both in vitro and in vivo.

Conclusion
The superior imaging properties of IR783-AMBF3 could lead to enhanced accuracy in the treatment of patients and would assist surgeons in non-invasively diagnosing diseases of the CNS.
The presence of Mycoplasma bovis in colostrum
Authors: Gille Linde , Evrard Julien , Callens Jozefien , Supré Karlien , Grégoire Fabien , Boyen Filip , Haesebrouck Freddy , Deprez Piet , Pardon Bart 
Published: April 2020

AbstractIn herds withMycoplasma boviscirculation, colostrum is often considered infectious. However, in contrast to milk, the presence ofM. bovisin colostrum was not previously evidenced. In this survey, the presence ofM. bovisDNA was determined with real-time PCR in 368 colostrum samples from 17 herds, recently infected withM. bovis. Only 1.9% of the samples tested positive, with 13 herds having no positive samples and an overall within-herd prevalence of 3.2% (SD: 4.9%; Range: 0–30.0%). These results show that in infected herdsM. bovisDNA can be retrieved in colostrum. To what extend colostrum is infectious remains to be determined.
SMOTE-Boost-based sparse Bayesian model for flood prediction
Authors: Wu Yirui , Ding Yukai , Feng Jun 
Published: April 2020

AbstractWith a significant development of big data analysis and cloud-fog-edge computing, human-centered computing (HCC) has been a hot research topic worldwide. Essentially, HCC is a cross-disciplinary research domain, in which the core idea is to build an efficient interaction among persons, cyber space, and real world. Inspired by the improvement of HCC on big data analysis, we intend to involve related core and technologies to help solve one of the most important issues in the real world, i.e., flood prediction. To minimize the negative impacts brought by floods, researchers pay special attention to improve the accuracy of flood forecasting with quantity of technologies including HCC. However, historical flood data is essentially imbalanced. Imbalanced data causes machine learning classifiers to be more biased towards patterns with majority samples, resulting in poor classification of pattern with minority samples. In this paper, we propose a novel Synthetic Minority Over-sampling Technique (SMOTE)-Boost-based sparse Bayesian model to perform flood prediction with both high accuracy and robustness. The proposed model consists of three modules, namely, SMOTE-based data enhancement, AdaBoost training strategy, and sparse Bayes model construction. In SMOTE-based data enhancement, we adopt a SMOTE algorithm to effectively cover diverse data modes and generate more samples for prediction pattern with minority samples, which greatly alleviates the problem of imbalanced data by involving experts’ analysis and users’ intentions. During AdaBoost training strategy, we propose a specifically designed AdaBoost training strategy for sparse Bayesian model, which not only adaptively and inclemently increases prediction ability of Bayesian model, but also prevents its over-fitting performance. Essentially, the design of AdaBoost strategy helps keep balance between prediction ability and model complexity, which offers different but effective models over diverse rivers and users. Finally, we construct a sparse Bayesian model based on AdaBoost training strategy, which could offer flood prediction results with high rationality and robustness. We demonstrate the accuracy and effectiveness of the proposed model for flood prediction by conducting experiments on a collected dataset with several comparative methods.
Positive periodic solutions for high-order differential equations with multiple delays in Banach spaces
Authors: Liang Yue , Li Hong 
Published: April 2020

AbstractThis paper deals with the existence of positive ω-periodic solutions for nth-order ordinary differential equation with delays in Banach space E of the form $$L_{n}u(t)=f\bigl(t,u(t-\tau_{1}),\ldots,u(t- \tau_{m})\bigr),\quad t\in\mathbb{R}, $$Lnu(t)=f(t,u(t−τ1),…,u(t−τm)),t∈R, where $L_{n}u(t)=u^{(n)}(t)+\sum_{i=0}^{n-1}a_{i} u^{(i)}(t)$Lnu(t)=u(n)(t)+∑i=0n−1aiu(i)(t) is the nth-order linear differential operator, $a_{i}\in\mathbb {R}$ai∈R ($i=0,1,\ldots,n-1$i=0,1,…,n−1) are constants, $f: \mathbb{R}\times E^{m}\rightarrow E$f:R×Em→E is a continuous function which is ω-periodic with respect to t, and $\tau_{i}>0$τi>0 ($i=1,2,\ldots,m$i=1,2,…,m) are constants which denote the time delays. We first prove the existence of ω-periodic solutions of the corresponding linear problem. Then the strong positivity estimation is established. Finally, two existence theorems of positive ω-periodic solutions are proved. Our discussion is based on the theory of fixed point index in cones.
A case report of Gorham-Stout disease diagnosed during the course of recurrent meningitis and cholesteatoma
Authors: Hosoya Makoto , Oishi Naoki , Nishiyama Jun , Ogawa Kaoru 
Published: April 2020

Background Gorham-Stout disease is a rare bone disorder. Here, we present a case of Gorham-Stout disease diagnosed during follow-up of a patient with cholesteatoma; the disease affected the temporal bone and other sites of the skull. To the best of our knowledge, this is the first report of Gorham-Stout disease diagnosed with recurrent cerebrospinal leakage after surgery to treat cholesteatoma. Case presentation A 25-year-old male patient re-presented to our department for the first time in 7 years with otorrhea in the right ear and recurrent meningitis. The patient had a history of multiple surgeries for cholesteatoma and suffered from recurrent cerebrospinal fluid leakage, which initially was thought to be caused by recurrence of cholesteatoma. Therefore, skull base reconstruction was planned. However, the underlying cause was identified eventually as defects in the temporal bone caused by massive osteolysis due to Gorham-Stout disease. Skull base reconstruction was abandoned because the osteolysis was considered to be progressive. Conservative treatment with infectious control was implemented as an alternative. Conclusion This case describes unusual temporal bone osteolysis after cholesteatoma surgery and the importance of considering the possibility of multiple concurrent diseases in such individuals. The distinguishing features of this case are the fact that the temporal bone had disappeared, and deconstruction was complicated by infection and inflammation caused by cholesteatoma, surgical invasion, and Gorham-Stout disease. Appropriate diagnosis saved the patient from ineffective multiple surgeries for cerebrospinal fluid leakage or cholesteatoma, and improved his quality of life.
Supply ranges of stone blocks used in masonry bridges and their construction period along the East Royal Road in the Khmer Empire, Cambodia
Authors: Uchida Etsuo , Sakurai Yuichiro , Cheng Rathborith , Shimoda Ichita , Saito Yu 
Published: April 2020

Abstract
During the Angkor period, there were five Royal Roads linking the capital city of Angkor with provincial principal cities. Seven Temples d’étape, six Fire Shrines, and 25 masonry bridges were constructed along the East Royal Road to Preah Khan of Kompong Svay. We conducted measurements of magnetic susceptibility and chemical composition of laterite blocks and magnetic susceptibility of sandstone blocks used for the construction of the bridges to determine the supply ranges of the stone blocks and the construction ages based on the results obtained in this study and previous studies of Temples d’étape and Fire Shrines. The results suggest that most of the sandstone blocks for the bridge balustrades were supplied from quarries in the southeastern foothills of Kulen Mountain, but that the bridges close to Preah Khan of Kompong Svay have sandstone balustrades supplied from nearby quarries. In contrast, cluster and principal component analyses and t-tests using data for chemical composition and magnetic susceptibility of laterite blocks revealed that there were five sources of supply. These results elucidated that the supply ranges of laterite blocks were narrower than those of the sandstone blocks. Judging from magnetic susceptibilities, supply ranges, shapes, orientations of bedding planes, and stacking methods of the stone blocks, it was concluded that the construction age of the bridges is highly likely to have been in the early Angkor Wat period.