bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal history of the western Central Taurides fold-thrust belt: Implications for Cenozoic vertical motions of southern Central Anatolia
Authors: McPhee Peter J. , van Hinsbergen Douwe J.J. , Thomson Stuart N. 
Published: November 2019

AbstractThe modern physiography of central Turkey is dominated by the 1-km-high Central Anatolian Plateau and the Central Tauride mountains that form the southern plateau margin. These correspond to a Cretaceous–Eocene backarc extensional province and forearc fold-thrust belt, respectively. The extent to which the morphology of the Miocene plateau was inherited from the physiography of the Cretaceous–Eocene subduction zone that assembled the Anatolian crust has not been tested but is important if we are to isolate the signal of Miocene and younger subduction dynamics in the formation of the modern plateau margin. There is no known stratigraphic record of the post-Eocene pre-Miocene evolution of the Taurides. We therefore collected rock samples across the Taurides and used zircon (U-Th)/He (ZHe), apatite (U-Th)/He (AHe), and apatite fission-track (AFT) low-temperature thermochronometers to constrain cooling; we interpret these thermochronometers to signal erosional exhumation. We use inverse thermal modeling to aid interpretation of our results and find that: (1) thermochronometers across the Taurides were reset as a result of heating by the emplacement of the Antalya and Bozkır nappes; (2) AFT and ZHe Eocene cooling ages are related to structurally driven uplift and erosional exhumation on major thrust culminations; (3) dispersed AHe ages record low rates of Oligocene–early Miocene cooling and hence low rates of erosional exhumation; and (4) fast rates of cooling were determined for samples along the margin of the Köprüçay Basin. We interpret that early Miocene cooling is a signal of active erosion of the western Central Taurides at a time of marine sedimentation in the Mut Basin on the southern Central Taurides, and these differing histories may reflect evolution above the Antalya and Cyprus slabs. Our thermochronological data, the enigmatic development of the Antalya Basin, and thrusting within the basin may be explained as the surface expression of stepwise delamination of the Antalya slab from the Tauride hinterland to its current position below the Gulf of Antalya since early Miocene time over a distance of ∼150 km.
Lasting impact: a qualitative study of perspectives on surgery by adult recipients of free mission-based surgical care in Benin
Authors: Close Kristin L , Christie-de Jong Floor T.E. 
Published: November 2019

ObjectivesThis study aimed to explore how adult patients who received free mission-based elective surgery experienced surgery and its outcomes, in order to provide recommendations for improved service delivery, measurement of impact and future quality initiatives for the humanitarian organisation Mercy Ships and other mission-based surgical platforms.SettingData were collected in June 2017 in Cotonou, Benin, where the participants had previously received free mission-based elective surgery aboard theAfrica Mercy,a non-governmental hospital ship.ParticipantsSixteen patients (seven male, nine female, age range 22–71, mean age 43.25) who had previously received surgical care aboard theAfrica Mercyhospital ship between September 2016 and May 2017 participated in the study.MethodsUsing a qualitative design, 16 individual semistructured interviews were conducted with the assistance of two interpreters. Participants were recruited using purposive sampling from the Mercy Ships patient database. Interview data were coded and organised into themes and subthemes using thematic content analysis in an interpretivist approach.FindingsAnalysis of interview data revealed three main themes: barriers to surgery, experiences with Mercy Ships and changes in perspectives of surgery after their experiences. Key findings included barriers to local surgical provision such as cost, a noteworthy amount of fear and distrust of local surgical teams, exceptional positive experiences with the care at Mercy Ships, and impactful surgery, resulting in high levels of trust in foreign surgical teams.ConclusionsWhile foreign surgical teams are meeting an immediate need for surgical care, the potential enduring legacy is one of trusting only foreigners for surgery. Patients are a critical component to a well-functioning surgical system, and mission-based surgical providers must formulate strategies to mitigate this legacy while strengthening the local surgical system.
Is neck circumference an appropriate tool to predict cardiovascular risk in clinical practice? A cross-sectional study in Chilean population
Authors: Caro Patricia , Guerra Ximena , Canals Andrea , Weisstaub Gerardo , Sandaña Carlos 
Published: November 2019

ObjectivesNeck circumference has emerged as a predictor of obesity and metabolic syndrome, but its clinical usefulness for different groups of population is not clearly defined. The aim is to evaluate the predictive capacity of neck circumference in order to detect cardiovascular risks (CVRs) on the Chilean population and to compare it with waist circumference performance.DesignCross-sectional study.SettingGeneral Chilean population.ParticipantsData of 4607 adults aged 18 and over from the Chilean National Health Survey 2009–2010 were analysed.Primary and secondary outcome measuresAnthropometrics measures included neck and waist circumference, height and weight. CVR was identified according to the Framingham tables adapted for the Chilean population. Receiver operating characteristics curves and logistic regression models were made to evaluate the performance of neck circumference to predict a moderate/high CVR, comparing it to waist circumference.ResultsAlmost 10% of the sample had a moderate or high CVR. The probability of having a moderate/high cardiovascular risk increase with cervical obesity (OR 1.95, 95% CI 1.04 to 3.68) and central obesity (OR 4.5, 95% CI 2.47 to 8.22). The area under the curves were high for cervical obesity (AUC 81.4%, 95% CI 78.8% to 84.0%) and central obesity (AUC 82.2%, 95% CI 79.7% to 84.7%) and not statistically different (p=0.152).ConclusionsNeck obesity has a high capacity to predict moderate/high CVR in the Chilean population. Its good performance appears as an opportunity to use it in clinical practice when waist circumference measurement is difficult to measure and eventually replace the waist circumference measurement as the technique is easier.
Ethnicity and risk of diagnosed dementia after stroke: a cohort study using the Clinical Practice Research Datalink
Authors: Shiekh Suhail Ismail , Forbes Harriet , Mathur Rohini , Smeeth Liam , Pearce Neil , Warren-Gash Charlotte 
Published: November 2019

IntroductionThe UK has over 1.2 million stroke survivors. Stroke is a major risk factor for dementia, and along with other risk factors such as hypertension and diabetes, is more common among Black, Asian and other ethnic minorities (BAME). We aimed to explore whether diagnosed dementia differed by ethnicity among adult stroke survivors.MethodologyUsing the UK Clinical Practice Research Datalink and linked hospital data, we conducted a cohort study among patients aged ≥40 years who had an incident stroke between 2005 and 2016. We fitted multivariable Cox proportional hazard models to estimate ethnic differences in the risk of poststroke dementia, adjusting for major clinical and social confounders.ResultsOur cohort comprised 45 474 stroke survivors (mean age 72.6 years, 49% female), of whom 95.7% were White, 2.0% South Asian, 1.2% Black and 1.1% of Mixed/Other ethnicity. Of these, 4624 (10.2%) were diagnosed with poststroke dementia over a median follow-up of 3.26 years. Compared with the White ethnic group, those of Black ethnicity were 42% more likely to be diagnosed with dementia (adjusted HR 1.42, 95% CI 1.05 to 1.93). There was no association between any other ethnic group and poststroke dementia diagnosis.DiscussionThere was good evidence that those of Black ethnicity had higher risk of diagnosed dementia poststroke. Further understanding of the mechanisms of this relationship could help target interventions at communities most at risk of dementia poststroke.
The Code-Theoretic Axiom: The Third Ontology
Authors: Irwin Klee 
Published: November 2019

A logical physical ontology is code theory, wherein reality is neither deterministic nor random. In light of Conway and Kochen’s free will theorem [The free will theorem, Found. Phys. 36(10) (2006) 1441–1473] and strong free will theorem [The strong free will theorem, Not. Am. Math. Soc. 56(2) (2009) 226–232], we discuss the plausibility of a third axiomatic option — geometric language; the code-theoretic axiom. We suggest that freewill choices at the syntactically-free steps of a geometric language of spacetime form the code-theoretic substrate upon which particle and gravitational physics emerge.
Archean crustal evolution of the Bundelkhand Craton: evidence from granitoid magmatism
Authors: Singh Vinod K. , Verma Sanjeet K. , Singh Pradip K. , Slabunov A. I. , Mishra Sumit , Chaudhary Neeraj 
Published: November 2019

Abstract

This study presents petrological and geochemical data on Neoarchean granitoids from the northern and central parts of the Bundelkhand Craton to discuss its crustal evolution and tectonic history. The study deals with two granitoid suites, i.e. tonalites–trondhjemites–granodiorites (TTG) and sanukitoids. TTGs are characterized by high SiO
2
, Na
2
O and mostly low to moderate Mg#. They display enrichment in light rare earth elements, low to moderately fractionated heavy rare earth elements (HREE) and low Sr/Y ratios, suggesting their high-HREE character or low-pressure origin from melting of a mafic protolith. The sanukitoid samples show relatively low SiO
2
, high K
2
O (2.1–4.6 wt%), Pb, Sr and Ba, and moderate to low Mg#, Cr, Ni. These granitoids probably generated from partial melting of hydrous mafic rocks followed by interaction with a mantle peridotite. Geochemical characteristics, tectonic discrimination using ratios like (Ce/Pb)
PM
, (La/Nb)
PM
and (Th/Nb)
PM
and regional rock association suggest that the Neoarchean TTGs and sanukitoids were emplaced in a subduction setting. Combining the existing knowledge base, a schematic model for generation and evolution of crust from Paleoarchean to Neoarchean has been proposed for the Bundelkhand Craton.
Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation
Authors: Fernández-Nogueira Patricia , Mancino Mario , Fuster Gemma , López-Plana Anna , Jauregui Patricia , Almendro Vanesa , Enreig Estel , Menéndez Silvia , Rojo Federico , Noguera-Castells Aleix , Bill Anke , Gaither L. Alex , Serrano Laia , Recalde-Percaz Leire , Moragas Núria , Alonso Raul , Ametller Elisabet , Rovira Ana , Lluch Ana , Albanell Joan , Gascon Pere , Bragado Paloma 
Published: November 2019

AbstractPurpose:Despite the therapeutic success of existing HER2-targeted therapies, tumors invariably relapse. This study aimed at identifying new mechanisms responsible for HER2-targeted therapy resistance.Experimental Design:We have used a platform of HER2-targeted therapy–resistant cell lines and primary cultures of healthy and tumor-associated fibroblasts (TAF) to identify new potential targets related to tumor escape from anti-HER2 therapies.Results:We have shown that TAFs promote resistance to HER2-targeted therapies. TAFs produce and secrete high levels of FGF5, which induces FGFR2 activation in the surrounding breast cancer cells. FGFR2 transactivates HER2 via c-Src, leading to resistance to HER2-targeted therapies. In vivo, coinoculating nonresistant cell lines with TAFs results in more aggressive and resistant tumors. Resistant cells activate fibroblasts and secrete FGFR ligands, creating a positive feedback loop that fuels resistance. FGFR2 inhibition not only inhibits HER2 activation, but also induces apoptosis in cells resistant to HER2-targeted therapies. In vivo, inhibitors of FGFR2 reverse resistance and resensitize resistant cells to HER2-targeted therapies. In HER2 patients' samples, α-SMA, FGF5, and FGFR2 contribute to poor outcome and correlate with c-Src activation. Importantly, expression of FGF5 and phospho-HER2 correlated with a reduced pathologic complete response rate in patients with HER2-positive breast cancer treated with neoadjuvant trastuzumab, which highlights the significant role of TAFs/FGF5 in HER2 breast cancer progression and resistance.Conclusions:We have identified the TAF/FGF5/FGFR2/c-Src/HER2 axis as an escape pathway responsible for HER2-targeted therapy resistance in breast cancer, which can be reversed by FGFR inhibitors.
Combined Vaccination with NY-ESO-1 Protein, Poly-ICLC, and Montanide Improves Humoral and Cellular Immune Responses in Patients with High-Risk Melanoma
Authors: Pavlick Anna , Blazquez Ana B. , Meseck Marcia , Lattanzi Michael , Ott Patrick A. , Marron Thomas U. , Holman Rose Marie , Mandeli John , Salazar Andres M. , McClain Christopher B. , Gimenez Gustavo , Balan Sreekumar , Gnjatic Sacha , Sabado Rachel Lubong , Bhardwaj Nina 
Published: November 2019

AbstractGiven its ability to induce both humoral and cellular immune responses, NY-ESO-1 has been considered a suitable antigen for a cancer vaccine. Despite promising results from early-phase clinical studies in patients with melanoma, NY-ESO-1 vaccine immunotherapy has not been widely investigated in larger trials; consequently, many questions remain as to the optimal vaccine formulation, predictive biomarkers, and sequencing and timing of vaccines in melanoma treatment. We conducted an adjuvant phase I/II clinical trial in high-risk resected melanoma to optimize the delivery of poly-ICLC, a TLR-3/MDA-5 agonist, as a component of vaccine formulation. A phase I dose-escalation part was undertaken to identify the MTD of poly-ICLC administered in combination with NY-ESO-1 and montanide. This was followed by a randomized phase II part investigating the MTD of poly-ICLC with NY-ESO-1 with or without montanide. The vaccine regimens were generally well tolerated, with no treatment-related grade 3/4 adverse events. Both regimens induced integrated NY-ESO-1–specific CD4+ T-cell and humoral responses. CD8+ T-cell responses were mainly detected in patients receiving montanide. T-cell avidity toward NY-ESO-1 peptides was higher in patients vaccinated with montanide. In conclusion, NY-ESO-1 protein in combination with poly-ICLC is safe, well tolerated, and capable of inducing integrated antibody and CD4+ T-cell responses in most patients. Combination with montanide enhances antigen-specific T-cell avidity and CD8+ T-cell cross-priming in a fraction of patients, indicating that montanide contributes to the induction of specific CD8+ T-cell responses to NY-ESO-1.
Infective Endocarditis Following Transcatheter Aortic Valve Replacement
Authors: Regueiro Ander , Linke Axel , Latib Azeem , Ihlemann Nikolaj , Urena Marina , Walther Thomas , Husser Oliver , Herrmann Howard C. , Nombela-Franco Luis , Cheema Asim , Le Breton Hervé , Stortecky Stefan , Kapadia Samir , Bartorelli Antonio L. , Sinning Jan Malte , Amat-Santos Ignacio , Munoz-Garcia Antonio J. , Lerakis Stamatios , Gutiérrez-Ibanes Enrique , Abdel-Wahab Mohamed , Tchetche Didier , Testa Luca , Eltchaninoff Helene , Livi Ugolino , Castillo Juan Carlos , Jilaihawi Hasan , Webb John G. , Barbanti Marco , Kodali Susheel , de Brito Fabio S. , Ribeiro Henrique B. , Miceli Antonio , Fiorina Claudia , Actis Dato Guglielmo Mario , Rosato Francesco , Serra Vicenç , Masson Jean-Bernard , Wijeysundera Harindra C. , Mangione Jose A. , Ferreira Maria-Cristina , Lima Valter C. , Carvalho Luis A. , Abizaid Alexandre , Marino Marcos A. , Esteves Vinicius , Andrea Julio C.M. , Messika-Zeitoun David , Himbert Dominique , Kim Won-Keun , Pellegrini Costanza , Auffret Vincent , Nietlispach Fabian , Pilgrim Thomas , Durand Eric , Lisko John , Makkar Raj R. , Lemos Pedro , Leon Martin B. , Puri Rishi , San Roman Alberto , Vahanian Alec , Søndergaard Lars , Mangner Norman , Rodés-Cabau Josep 
Published: November 2019

Background:
No data exist about the characteristics of infective endocarditis (IE) post-transcatheter aortic valve replacement (TAVR) according to transcatheter valve type. We aimed to determine the incidence, clinical characteristics, and outcomes of patients with IE post-TAVR treated with balloon-expandable valve (BEV) versus self-expanding valve (SEV) systems.

Methods:
Data from the multicenter Infectious Endocarditis After TAVR International Registry was used to compare IE patients with BEV versus SEV.

Results:

A total of 245 patients with IE post-TAVR were included (SEV, 47%; BEV, 53%). The timing between TAVR and IE was similar between groups (SEV, 5.5 [1.2–15] months versus BEV, 5.3 [1.7–11.4] months;
P
=0.89). Enterococcal IE was more frequent in the SEV group (36.5% versus 15.4%;
P
<0.01), and vegetation location differed according to valve type (stent frame, SEV, 18.6%; BEV, 6.9%;
P
=0.01; valve leaflet, SEV, 23.9%; BEV, 38.5%;
P
=0.01). BEV recipients had a higher rate of stroke/systemic embolism (20.0% versus 8.7%, adjusted OR: 2.46, 95% CI: 1.04–5.82,
P
=0.04). Surgical explant of the transcatheter valve (SEV, 8.7%; BEV, 13.8%;
P
=0.21), and in-hospital death at the time of IE episode (SEV, 35.6%; BEV, 37.7%;
P
=0.74) were similar between groups. After a mean follow-up of 13±12 months, 59.1% and 54.6% of the SEV and BEV recipients, respectively, had died (
P
=0.66).

Conclusions:
The characteristics of IE post-TAVR, including microorganism type, vegetation location, and embolic complications but not early or late mortality, differed according to valve type. These results may help to guide the diagnosis and management of IE and inform future research studies in the field.
Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia
Authors: Colloby Sean J , Watson Rosie , Blamire Andrew M , O’Brien John T , Taylor John-Paul 
Published: November 2019

Background: We investigated the structural changes associated with Alzheimer’s disease, dementia with Lewy bodies and Parkinson disease dementia by means of cortical thickness analysis. Methods: Two hundred and forty-five participants: 76 Alzheimer’s disease, 65 dementia with Lewy bodies, 29 Parkinson disease dementia and 76 cognitively normal controls underwent 3-T T1-weighted magnetic resonance imaging and clinical and cognitive assessments. We implemented FreeSurfer to obtain cortical thickness estimates to contrast patterns of cortical thinning across groups and their clinical correlates. Results: In Alzheimer’s disease and dementia with Lewy bodies, a largely similar pattern of regional cortical thinning was observed relative to controls apart from a more severe loss within the entorhinal and parahippocampal structures in Alzheimer’s disease. In Parkinson disease dementia, regional cortical thickness was indistinguishable from controls and dementia with Lewy bodies, suggesting an ‘intermediate’ pattern of regional cortical change. In terms of global cortical thickness, group profiles were controls > Parkinson disease dementia > dementia with Lewy bodies > Alzheimer’s disease (F3, 241 ⩽ 123.2, p < 0.001), where percentage wise, the average difference compared to controls were −1.8%, −5.5% and −6.4%, respectively. In these samples, cortical thinning was also associated with cognitive decline in dementia with Lewy bodies but not in Parkinson disease dementia and Alzheimer’s disease. Conclusion: In a large and well-characterised cohort of people with dementia, regional cortical thinning in dementia with Lewy bodies was broadly similar to Alzheimer’s disease. There was preservation of the medial temporal lobe structures in dementia with Lewy bodies compared with Alzheimer’s disease, supporting its inclusion as a supportive biomarker in the revised clinical criteria for dementia with Lewy bodies. However, there was less global cortical thinning in Parkinson disease dementia, with no significant regional difference between Parkinson disease dementia and controls. These findings highlight the overlap across the Alzheimer’s disease/Parkinson disease dementia spectrum and the potential for differing mechanisms underlying neurodegeneration and cognition in dementia with Lewy bodies and Parkinson disease dementia.
Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects
Authors: Al-Karagholi Mohammad Al-Mahdi , Ghanizada Hashmat , Hansen Jakob Møller , Aghazadeh Sameera , Skovgaard Lene Theil , Olesen Jes , Ashina Messoud 
Published: November 2019

Introduction Levcromakalim opens ATP-sensitive potassium channels (KATP channel) and induces head pain in healthy volunteers and migraine headache in migraine patients, but no pain in other parts of the body. KATP channels are expressed in C- and Aδ-fibers, and these channels might directly activate nociceptors and thereby evoke pain in humans. Methods To assess the local effect of KATP channel opening in trigeminal and extra-trigeminal regions, we performed a crossover, double-blind, placebo-controlled study in healthy volunteers. Participants received intradermal and intramuscular injections of levcromakalim and placebo in the forehead and the forearms. Results Intradermal and intramuscular injections of levcromakalim did not evoke more pain compared to placebo in the forehead ( p > 0.05) and the forearms ( p > 0.05). Intradermal injection of levcromakalim caused more flare ( p < 0.001 ), skin temperature increase ( p < 0.001), and skin blood flow increase ( p < 0.001) compared to placebo in the forehead and the forearms. Conclusion These findings suggest that it is unlikely that levcromakalim induces head pain by direct activation of peripheral neurons.
Do American Youth Football Players Intentionally Use Their Heads for High-Magnitude Impacts?
Authors: Alois Jaclyn , Bellamkonda Srinidhi , Campolettano Eamon T. , Gellner Ryan A. , Genemaras Amaris , Beckwith Jonathan G. , Greenwald Richard M. , Smith Eric , Rowson Steven , Duma Stefan M. , Crisco Joseph J. 
Published: November 2019

Background: Concern for head injuries is widespread and has been reported by the media to be the number one cause of decreased participation in football among the American youth population. Identifying player mechanisms associated with intentional, or purposeful, head impacts should provide critical data for rule modifications, educational programs, and equipment design. Purpose: To investigate the frequency of intentional and unintentional head impacts and to examine the player mechanisms associated with intentional high-magnitude head impacts by comparing the impact mechanism distributions among session type, player position, and ball possession. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Head impact sensors and video footage of 68 players were used to analyze and classify 1319 high-magnitude impacts recorded over 1 season of youth football. Results: In total, 80% of the high-magnitude head impacts were classified as being caused by intentional use of the head. Head-to-head impact was the primary impact mechanism (n = 868; 82.7%) within the 1050 intentional high-magnitude impacts, with classifiable mechanisms, followed by head-to-body (n = 139; 13.2%), head-to-ground (n = 34; 3.2%), and head-to-equipment (n = 9; 0.9%). Head-to-head impacts also accounted for a greater proportion of impacts during practices (n = 625; 88.9%) than games, for linemen (n = 585; 90.3%) than perimeters and backs, and for ball carriers (n = 72; 79.1%) than tacklers. Conclusion: Overall, the majority of high-magnitude head impacts were intentional and resulted from head-to-head contact. The proportion of head-to-head contact was significantly higher for practices than games, linemen than backs and perimeter players, and ball carriers than tacklers.