bluuebunny/crossref_metadata_2025_split huggingface dataset:
Segmental Colectomy for Ulcerative Colitis: Is There a Place in Selected Patients Without Active Colitis? An International Multicentric Retrospective Study in 72 Patients
Authors: Frontali A , Cohen L , Bridoux V , Myrelid P , Sica G , Poggioli Gilberto , Espin E , Beyer-Berjot L , Laharie D , Spinelli A , Zerbib P , Sampietro G , Frasson M , Louis E , Danese S , Fumery M , Denost Q , Altwegg R , Nancey S , Michelassi F , Treton X , Panis Y 
Published: May 2020

Abstract

Background and Aims
The aim of this study was to report a multicentric experience of segmental colectomy [SC] in ulcerative colitis [UC] patients without active colitis, in order to assess if SC can or cannot represent an alternative to ileal pouch-anal anastomosis [IPAA].

Methods
All UC patients undergoing SC were included. Postoperative complications according to ClavienDindo’s classification, long term results, and risk factors for postoperative colitis and reoperation for colitis on the remnant colon, were assessed.

Results: A total of
72 UC patients underwent: sigmoidectomy [n = 28], right colectomy [n = 24], proctectomy [n = 11], or left colectomy [n = 9] for colonic cancer [n = 27], ‘diverticulitis’ [n = 17], colonic stenosis [n = 5], dysplasia or polyps [n = 8], and miscellaneous [n = 15]. Three patients died postoperatively and 5/69 patients [7%] developed early flare of UC within 3 months after SC. After a median followup of 40 months, 24/69 patients [35%] were reoperated after a median delay after SC of 19 months [range, 2–158 months]: 22/24 [92%] underwent total colectomy and ileorectal anastomosis [n = 9] or total coloproctectomy [TCP] [n = 13] and 2/24 [8%] an additional SC. Reasons for reoperation were: colitis [n = 14; 20%], cancer [n = 3] or dysplasia [n = 3], colonic stenosis [n = 1], and unknown reasons [n = 3]. Endoscopic score of colitis before SC was Mayo 23 in 5/5 [100%] patients with early flare vs 15/42 without early flare [36%; p = 0.0101] and in 9/12 [75%] patients with reoperation for colitis vs 11/35 without reoperation [31%; p = 0.016].

Conclusions
After segmental colectomy in UC patients, postoperative early colitis is rare [7%]. Segmental colectomy could possibly represent an alternative to IPAA in selected UC patients without active colitis.
Patient satisfaction after orthognathic surgery: a 3 year follow-up of 60 high-angle Class II individuals
Authors: Torgersbråten Nina , Stenvik Arild , Espeland Lisen 
Published: May 2020

Summary

Background and objectives
High-angle Class II malocclusion is considered challenging to treat to a stable result and, although studies report treatment outcome in terms of morphology, patient satisfaction has not been addressed. The objectives of the present study were to examine patients’ motives for treatment and satisfaction with the results.

Material and methods
A structured questionnaire was distributed 3 years post-operatively to 93 consecutively treated patients with an initial diagnosis of mandibular-plane angle (ML/NSL) ≥34.0 degrees and ANB angle ≥4.0 degrees. Three surgical subsamples were defined: one-piece Le Fort I, bilateral sagittal split osteotomy, or a combination of the two (Bimax). Lateral cephalometric radiographs were used to assess morphological characteristics and post-treatment changes.

Results
Questionnaire participation was 69.8 per cent. The most frequently reported motives for seeking treatment were to improve oral function (85.0 per cent) and dental appearance (71.7 per cent). Thirty per cent were very satisfied, 53.3 per cent were satisfied, and 16.7 per cent were dissatisfied with the overall treatment result. Dissatisfaction was associated with a persisting post-treatment anterior open bite (AOB), horizontal relapse at B point, and with sensory impairment.

Conclusions and implications
A higher rate of dissatisfaction was found than what has usually been reported for othognathic surgical patients, and this was associated with a persisting AOB. In addition, mandibular relapse and impaired sensory function were related to dissatisfaction and are associated with mandibular surgery. Prospective high-angle Class II patients should be comprehensively informed about the unpredictability of treatment outcomes in terms of occlusion and facial appearance.
Using gravity gradients to estimate fault parameters in the Wichita Uplift region
Authors: Uzun Sibel , Erkan Kamil , Jekeli Christopher 
Published: May 2020

SUMMARY
The geological setting of southwestern Oklahoma and northeastern Texas is an ideal example of an aulacogen, the result of the tectonic evolution of a failed rift of the North American continent during the Palaeozoic era (540–360 Ma). The Wichita Province forms the uplifted basement portion of this Southern Oklahoma Aulacogen (SOA). The major fault zones to its north and south are clearly evident in gravity gradient maps produced by the recently constructed Earth Gravitational Model 2008 (EGM2008). Fault parameters, such as the dip angle, location and density contrasts have been estimated from profiles of seismic data and local gravimetry in the 1990s. On the other hand, gravitational gradients that are derived from EGM2008 and then combined to form the differential field curvature are particularly indicative of linear structures such as dip-slip faults. They are used here exclusively, that is, without additional geophysical constraints, in an optimal, least-squares estimation based on the Monte Carlo technique of simulated annealing to determine dip angle and location parameters of the major faults that border the Wichita Uplift region. Results show that these faults have small dip angles, in basic agreement with the low-angle faults inferred from seismic studies. The EGM2008 gradients also appear in some cases to provide an improved map of the major faults in the region, thus offering a strong constraint on their location.
Predictors of High Health Care Utilization in Patients With Inflammatory Bowel Disease Within 1 Year of Establishing Specialist Care
Authors: Chudy-Onwugaje Kenechukwu , Mamunes Alexander P , Schwartz David A , Horst Sara , Cross Raymond K 
Published: June 2020

Abstract

Background
A small proportion of patients with inflammatory bowel disease (IBD) consume a disproportionate amount of health care resources, with most of these spent on unplanned care in emergency room (ER) and hospital visits. Interventions in those at high risk in the outpatient setting could reduce the need for future inpatient care. We sought to describe the characteristics predictive of high health care utilization within 1 year after an initial IBD clinic encounter.

Methods
This was a retrospective study of new IBD patients seen at the outpatient clinics of 2 tertiary IBD centers in the United States. Baseline sociodemographic and clinical characteristics were collected, and the number of IBD-related ER and hospital visits were recorded over the 1-year period after the initial clinic encounter. Patients with ≥2 visits (high utilizers) were compared with those with no visits.

Results
Of the 735 patients included in the final analysis, 106 (14.4%) were high utilizers, and they had a mean of 2.9 visits (maximum = 10) in the 1 year after their initial encounter. In multivariate analysis, insurance coverage through medical assistance (odds ratio [OR] 3.57; 95% confidence interval [CI], 1.38–9.20), steroid use (OR 1.83; 95% CI, 1.11–3.04), short inflammatory bowel disease questionnaire score &lt;50 (OR 2.29; 95% CI, 1.23–4.27), and current ostomy (OR 4.82; 95% CI, 1.51–15.37) were independently associated with high utilization.

Conclusions
Multidisciplinary care and resources should be preferentially channeled towards new clinic patients with severe disease and on medical assistance, as this could reduce future inpatient visits and result in cost savings.
Resource optimization for cancer pathways with aggregate diagnostic demand: a perishable inventory approach
Authors: Arruda Edilson F , Harper Paul , England Tracey , Gartner Daniel , Aspland Emma , Ourique Fabrício O , Crosby Tom 
Published: June 2020

AbstractThis work proposes a novel framework for planning the capacity of diagnostic tests in cancer pathways that considers the aggregate demand of referrals from multiple cancer specialties (sites). The framework includes an analytic tool that recursively assesses the overall daily demand for each diagnostic test and considers general distributions for both the incoming cancer referrals and the number of required specific tests for any given patient. By disaggregating the problem with respect to each diagnostic test, we are able to model the system as a perishable inventory problem that can be solved by means of generalized G/D/C queuing models, where the capacity $C$ is allowed to vary and can be seen as a random variable that is adjusted according to prescribed performance measures. The approach aims to provide public health and cancer services with recommendations to align capacity and demand for cancer diagnostic tests effectively and efficiently. Our case study illustrates the applicability of our methods on lung cancer referrals from UK’s National Health Service.
Impact of multiple hits with cognate antigen on memory CD8+ T-cell fate
Authors: Takamura Shiki 
Published: June 2020

Abstract
Antigen-driven activation of CD8+ T cells results in the development of a robust anti-pathogen response and ultimately leads to the establishment of long-lived memory T cells. During the primary response, CD8+ T cells interact multiple times with cognate antigen on distinct types of antigen-presenting cells. The timing, location and context of these antigen encounters significantly impact the differentiation programs initiated in the cells. Moderate re-activation in the periphery promotes the establishment of the tissue-resident memory T cells that serve as sentinels at the portal of pathogen entry. Under some circumstances, moderate re-activation of T cells in the periphery can result in the excessive expansion and accumulation of circulatory memory T cells, a process called memory inflation. In contrast, excessive re-activation stimuli generally impede conventional T-cell differentiation programs and can result in T-cell exhaustion. However, these conditions can also elicit a small population of exhausted T cells with a memory-like signature and self-renewal capability that are capable of responding to immunotherapy, and restoration of functional activity. Although it is clear that antigen re-encounter during the primary immune response has a significant impact on memory T-cell development, we still do not understand the molecular details that drive these fate decisions. Here, we review our understanding of how antigen encounters and re-activation events impact the array of memory CD8+ T-cell subsets subsequently generated. Identification of the molecular programs that drive memory T-cell generation will advance the development of new vaccine strategies that elicit high-quality CD8+ T-cell memory.
Substantial reduction of antibiotic-non-susceptible pneumococcal otitis media following PCV7/PCV13 sequential introduction
Authors: Ben-Shimol Shalom , Givon-Lavi Noga , Greenberg David , van der Beek Bart Adriaan , Leibovitz Eugene , Dagan Ron 
Published: May 2020

Abstract

Background
In the pre-pneumococcal conjugated vaccines (PCVs) era, serotypes included in the 7/13-valent PCVs (PCV7/PCV13) caused most pneumococcal otitis media (OM) and antibiotic-non-susceptible pneumococcal OM (ANSP-OM) episodes. In southern Israel, sequential PCV7/PCV13 introduction resulted in &gt;90% reduction of vaccine-serotype OM.

Objectives
We assessed the dynamics of ANSP-OM necessitating middle ear fluid culture following PCV7/PCV13 sequential introduction in young children.

Methods
This was a prospective, population-based, active surveillance. All episodes in children &lt;3 years old, during 2004–16, were included. Two subperiods were defined: (i) pre-PCV: 2004–08; and (ii) PCV13: 2014–16. ANSP was defined for the following antibiotics: penicillin (MIC ≥0.1 mg/L and ≥1.0 mg/L), macrolide, tetracycline, clindamycin, ceftriaxone, trimethoprim/sulfamethoxazole and chloramphenicol. MDR was defined as ANSP for ≥3 classes.

Results
Overall, 2270 pneumococcal OM episodes were identified. Annual overall pneumococcal, PCV13 and non-PCV13 serotype OM incidence declined by 86%, 97% and 33%, respectively, comparing pre-PCV with the PCV13 period. During 2004–08, 95% of ANSP was observed in vaccine serotypes. Incidence of penicillin (MIC ≥0.1 mg/L and ≥1.0 mg/L), macrolide, tetracycline, clindamycin, ceftriaxone and multidrug ANSP-OM declined by &gt;90% in the PCV13 period. Rates of trimethoprim/sulfamethoxazole and chloramphenicol ANSP-OM declined by 85% and 79%, respectively. The proportions of ANSP of all pneumococcal isolates declined by ∼70% for penicillin, ceftriaxone and erythromycin; 53% for tetracycline; and 55% for MDR, versus no significant reductions observed for chloramphenicol, trimethoprim/sulfamethoxazole and clindamycin.

Conclusions
PCV7/PCV13 sequential introduction resulted in rapid and substantial ANSP-OM reduction, in parallel with the near disappearance of PCV13-serotype OM and no increase in replacement disease.
Hospital adoption of electronic health record functions to support age-friendly care: results from a national survey
Authors: Adler-Milstein Julia , Raphael Katherine , Bonner Alice , Pelton Leslie , Fulmer Terry 
Published: June 2020

Abstract

Objective
To measure US hospitals’ adoption of electronic health record (EHR) functions that support care for older adults, focusing on structured documentation of the 4Ms (What Matters, Medication, Mentation, and Mobility) and electronic health information exchange/communication with patients, caregivers, and long-term care providers.

Materials and Methods
In an online survey of a national, random sample of 797 US acute-care hospitals in 2018–2019, 479 (60.1%) responded. We calculated nationally representative measures of the percentages of hospitals with EHRs that include structured documentation of the 4Ms and exchange/communications functions.

Results
Structured EHR documentation of the 4Ms was fully implemented in at least 1 unit in 64.0% of hospitals and across all units in 41.5% of hospitals. Of the 4Ms, structured documentation was the highest for medications (91.3% in at least 1 unit) and the lowest for mentation (70.3% in at least 1 unit). All exchange/communication functions had been implemented in at least 1 unit in 16.2% of facilities and across all units in 7.6% of hospitals. Less than half of the hospitals had an EHR portal for long-term care facilities to access hospital information (45.4% in at least 1 unit), sent information electronically to long-term care facilities (44.6%), and had training for adults/caregivers on the patient portal (32.1%).

Discussion
Despite significant national investment in EHRs, hospital EHRs do not yet include key documentation, exchange, and communication functions needed to support evidence-based care for the older adults who comprise the majority of the inpatient population. Additional policy efforts are likely needed to promote the expansion of EHR capabilities into these high-value domains.

Conclusions
US acute-care hospital EHRs are lacking key functions that support care for older adults.
Aphid Feeding on Plant Lectins Falling Virus Transmission Rates: A Multicase Study
Authors: Francis Frederic , Chen Julian , Yong Liu , Bosquee Emilie 
Published: June 2020

Abstract
Aphids are insect vectors that have piercing–sucking mouthparts supporting diversified patterns of virus–vector interactions. Aphids primarily retain circulative viruses in the midgut/hindgut, whereas noncirculative viruses tend to be retained in the stylet. Most viruses, and many proteins from animals, have carbohydrate or carbohydrate-binding sites. Lectins vary in their specificity, of which some are able to bind to viral glycoproteins. To assess the potential competition between lectins and viral particles in virus transmission by aphids, this study examined how feeding plant lectins to aphids affects the transmission efficiency of viruses. Sitobion avenae (F, 1794) (Homoptera: Aphididae) aphids fed with Pisum sativum lectin (PSL) transmitted Barley yellow dwarf virus with significantly lower efficiency (four-fold ratio). Pea enation mosaic virus was significantly reduced in Acyrthosiphon pisum Harris (Homoptera: Aphididae) aphids fed with the lectin Concanavalin A. In comparison, the transmission of Potato virus Y was significantly reduced when Myzus persicae Sultzer (Homoptera: Aphididae) aphids were fed with PSL. Thus, lectin could be used as a blocking agent of plant viruses, facilitating an alternative approach for crop protection.
Evaluation of Unmanned Aerial Vehicles and Neural Networks for Integrated Mosquito Management of Aedes albopictus (Diptera: Culicidae)
Authors: Case Elizabeth , Shragai Talya , Harrington Laura , Ren Yue , Morreale Stephen , Erickson David 
Published: May 2020

AbstractAedes albopictus (Skuse), an invasive disease vector, poses a nuisance and public health threat to communities in the Northeastern United States. Climate change and ongoing adaptation are leading to range expansion of this mosquito into upstate New York and other northeastern states. Organized mosquito control can suppress populations, but it is time consuming, costly, and difficult as Ae. albopictus oviposits in small, artificial, water-holding containers. Unmanned aerial vehicles (UAVs), with centimeter-resolution imaging capabilities, can aid surveillance efforts. In this work, we show that a convolutional neural network trained on images from a UAV is able to detect Ae. albopictus habitat in suburban communities, and the number of containers successfully imaged by UAV predicted the number of containers positive for mosquito larvae per home. The neural network was able to identify some, but not all, potential habitat, with up to 67% precision and 40% recall, and can classify whole properties as positive or negative for larvae 80% of the time. This combined approach of UAV imaging and neutral network analysis has the potential to dramatically increase capacity for surveillance, increasing the reach and reducing the time necessary for conventional on-the-ground surveillance methods.
Insecticidal Activity ofCommiphora erythraeaEssential Oil and Its Emulsions Against Larvae of Three Mosquito Species
Authors: Muturi Ephantus J , Hay William T , Doll Kenneth M , Ramirez Jose L , Selling Gordon 
Published: May 2020

AbstractThe use of essential oils as ecofriendly tools for vector management is one of the mainstreams for biopesticide research. We evaluated the larvicidal properties of Commiphora erythraea (opoponax) essential oil and its fractions against Culex restuans Theobald, Culex pipiens L., and Aedes aegypti L. The use of bio-based amylose–N-1-hexadecylammonium chloride inclusion complex (Hex-Am) and amylose–sodium palmitate inclusion complex (Na-Palm) as emulsifiers for C. erythraea essential oil was also investigated. Bisabolene was the most abundant chemical constituent in the whole essential oil (33.9%), fraction 2 (62.5%), and fraction 4 (23.8%) while curzerene (32.6%) and α-santalene (30.1%) were the dominant chemical constituents in fractions 1 and 3, respectively. LC50 values for the whole essential oil were 19.05 ppm for Cx. restuans, 22.61 ppm for Cx. pipiens, and 29.83 ppm for Ae. aegypti and differed significantly. None of the four C. erythraea essential oil fractions were active against mosquito larvae. Two CYP450 genes (CYP6M11 and CYP6N12) and one GST gene (GST-2) were significantly upregulated in Ae. aegypti larvae exposed to C. erythraea essential oil suggesting their potential involvement in metabolic pathways for C. erythraea essential oil. Essential oil emulsions produced with Hex-Am were more toxic than the whole essential oil while those produced with Na-Palm had similar toxicity as the whole essential oil. These findings demonstrate that C. erythraea essential oil is a promising source of mosquito larvicide and that the use of Hex-Am as an emulsifier can enhance the insecticidal properties of C. erythraea essential oil.
Validation of the Healthcare Transition Outcomes Inventory for Young Adults With Type 1 Diabetes
Authors: Pierce Jessica , Hossain Jobayer , Gannon Anthony 
Published: June 2020

Abstract

Objective
We recently developed and content validated the Healthcare Transition Outcomes Inventory (HCTOI), a stakeholder vetted, multidimensional measure of the outcomes of the transition from pediatric to adult healthcare for young adults (YA) with type 1 diabetes (T1D). In this study, we aimed to evaluate the psychometric properties of the HCTOI.

Methods
We collected and analyzed cross-sectional data from 128 YA (18–25 years old) with T1D to evaluate the psychometric properties of the HCTOI. We conducted confirmatory factor analysis (CFA), item analysis, and examined reliability and validity in relation to measures of quality of life, diabetes distress, regimen adherence, and glycemic control.

Results
CFA supported a five-factor solution: integration of T1D into emerging adult roles, balance of parental support with T1D autonomy, establishing and maintaining continuity of care, forming a collaborative patient–provider relationship, and ownership of T1D. We reduced the HCTOI from 54 to 34 items. The HCTOI demonstrated adequate internal consistency (α’s = 0.62–0.87) and significant correlations demonstrated construct (quality of life, diabetes distress) and criterion validity (adherence, glycemic control).

Conclusions
The HCTOI demonstrated promising initial psychometric properties. As the first measure of the multiple dimensions of healthcare transition outcomes, the HCTOI provides a means to examine longitudinal relations between transition readiness and outcomes and to assess the efficacy or effectiveness of interventions and programs designed to improve the transition process for YA with T1D.
The nuclear region of NGC 613 – II. Kinematics and stellar archaeology
Authors: da Silva Patrícia , Menezes R B , Steiner J E , Fraga Luciano 
Published: May 2020

ABSTRACT
In this work, we continue the study of the central region of NGC 613 by da Silva, Menezes & Steiner (Paper I), by analysing the stellar and gas kinematics and the stellar archaeology in optical and near-infrared data cubes. The high spatial resolution of the Gemini Multi-Object Spectrograph (GMOS) data cube allowed the detection, using spectral synthesis methods, of an inner circumnuclear ring, with a radius of ∼1 arcsec, composed of ∼109-yr stellar populations. Such a ring is located between the nucleus and the circumnuclear ring composed by H ii regions detected in previous works. Besides that, there is a stellar rotation around the nucleus and the rings follow the same direction of rotation with different velocities. The intensity-weighted average stellar velocity dispersion at the centre is 92 ± 3 km s−1. Three distinct gas outflow components were detected. The direction of the outflow observed with the H α emission line is compatible with the direction of the previously observed radio jet. The direction of one of the outflows detected in the [O iii]λ5007 emission coincides with the axis of the ionization cone. There is no difference regarding the stellar populations and the stellar kinematics along the double stellar emission, probably separated by a dust lane as mentioned in Paper I, confirming that they are part of the same structure.