bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAS-303 effects on urethral sphincter function in women with stress urinary incontinence: phase I study
Authors: Yono Makoto , Irie Shin , Gotoh Momokazu 
Published: August 2020

Abstract
Introduction and hypothesis
TAS-303, which selectively inhibits noradrenaline reuptake, was developed for treating stress urinary incontinence (SUI). The proximal urethra mainly comprises smooth muscle fibers in which α1 adrenergic receptors are abundant. This study was conducted to evaluate the effect of TAS-303 on urethral function and its safety profile in female patients with SUI.

Methods
In total, 16 women (age, 20–64 years) with SUI and > 5.0 g of leakage in the 1-h pad test at screening were randomized and administered the assigned treatment in a double-blind manner. The primary end point was change in the maximal urethral closure pressure (MUCP) at 6 h post-dose. The secondary end point was change in the urethral closure pressure of the entire urethra and each urethral region (proximal, middle, and distal) at 6 h post-dose. The results were analyzed using a t-test.

Results
The mean change ± standard deviation in MUCP at 6 h post-dose was 3.473 ± 12.154 cmH2O for TAS-303 and 2.615 ± 9.794 cmH2O for placebo (between-group difference: 0.858 cmH2O, P = 0.8047). The mean changes ± standard deviation in urethral closure pressure of the proximal urethra at 6 h after the administration of TAS-303 18 mg and placebo were 3.863 ± 10.941 and 1.634 ± 12.093, respectively (between-group difference: 2.229 cmH2O, P = 0.5976).

Conclusions
No significant difference in MUCP and urethral closure pressure was found between TAS-303 and placebo. However, the change in the proximal urethral closure pressure with TAS-303 was larger than that with placebo. This suggests that TAS-303 has pharmacological effects on urethral sphincteric function.
Real-world efficacy of brentuximab vedotin plus bendamustine as a bridge to autologous hematopoietic stem cell transplantation in primary refractory or relapsed classical Hodgkin lymphoma
Authors: Pinczés László Imre , Szabó Roxána , Illés Árpád , Földeák Dóra , Piukovics Klára , Szomor Árpád , Gopcsa László , Miltényi Zsófia 
Published: August 2020

AbstractUp to 30% of patients with classical Hodgkin lymphoma (cHL) are not responsive to frontline therapy or relapse after primary treatment. In these cases, autologous hematopoietic stem cell transplantation (AHSCT) is the standard of care. The combination of brentuximab vedotin and bendamustine (BV + B) is an effective salvage regimen in this challenging subpopulation. This nationwide multicenter study investigated the real-world efficacy and safety of the BV + B regimen as a bridge to AHSCT in patients with primary refractory or relapsed cHL. A total of 41 cHL patients underwent AHSCT after receiving at least 1 cycle of BV + B (with brentuximab vedotin given at 1.8 mg/kg on day 1 and bendamustine at 90 mg/m2 on days 1–2 every 4 weeks). After a median of 3 (1–6) cycles of BV + B, the objective response rate was 78%, with 29 (70.7%) patients achieving complete remission. Twelve (29.3%) patients relapsed after AHSCT, 2 (4.9%) of them died, while 2 (4.9%) patients are lost to follow-up. After a median of 17 months of follow-up, the estimated 2-year overall- and progression-free survival after AHSCT was 93 and 62%, respectively. Features of advanced disease at recurrence (p = 0.038) and the presence of stage IV cHL at relapse (p = 0.024) are strong predictor markers of unfavorable outcomes. Twenty-four (58.5%) patients experienced adverse events of any grade, while no grade IV toxicities were reported. BV + B is an effective salvage option with a manageable toxicity profile in cHL. The real-world safety and efficacy of this combination are similar to the observations made on the study population.
Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration
Authors: Abbas Naisam , Perbellini Filippo , Thum Thomas 
Published: August 2020

AbstractSoon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved treatment and reperfusion strategies, the uncompensated cardiomyocyte loss during injury and disease results in cardiac remodeling and subsequent heart failure. The promising field of regenerative medicine aims to restore both the structure and function of damaged tissue through modulation of cellular processes and regulatory mechanisms involved in cardiac cell cycle arrest to boost cardiomyocyte proliferation. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are functional RNA molecules with no protein-coding function that have been reported to engage in cardiac regeneration and repair. In this review, we summarize the current understanding of both the biological functions and molecular mechanisms of ncRNAs involved in cardiomyocyte proliferation. Furthermore, we discuss their impact on the structure and contractile function of the heart in health and disease and their application for therapeutic interventions.
Ramsay Hunt syndrome: long-term facial palsy outcome assessed face-to-face by three different grading scales and compared to patient self-assessment
Authors: Kanerva Mervi , Jones Sanna , Pitkaranta Anne 
Published: August 2020

AbstractPurposeTo determine the long-term facial palsy outcome of Ramsay Hunt Syndrome by face-to-face grading by House–Brackmann Grading System, Facial Nerve Grading System 2.0, and Sunnybrook Facial Grading System concomitantly. To compare the applicability of the grading scales. To compare patients’ self-assessed facial palsy outcome results to gradings performed by the investigator. To compare the face-to-face assessed facial palsy outcome to the initial palsy grade.MethodsFifty-seven patients self-assessed their facial palsy outcome and came to a one-time follow-up visit. The palsy outcome was graded by one investigator using the three above-mentioned grading systems concomitantly. The median time from syndrome onset to follow-up visit was 6.6 years.ResultA good long-term face-to-face assessed palsy outcome was enjoyed by 84% of the patients. Trying to assess only one House–Brackmann grade to represent the palsy outcome was impossible for most patients. Facial Nerve Grading System 2.0 worked better, but needed adjustments and certain sequelae findings needed to be neglected for it to be executable. The Sunnybrook system worked the best. Nearly 20% of the patients assessed themselves differently from the investigator: both better and worse.ConclusionThe Sunnybrook scale was the most applicable system used. With antiviral medication, the outcome of facial palsy in Ramsay Hunt syndrome starts to resemble that of Bell’s palsy and emphasizes the importance of recognizing the syndrome and treating it accordingly. The results give hope to patients instead of the gloomy prospects that have stigmatized the syndrome.
Immunological combination treatment holds the key to improving survival in pancreatic cancer
Authors: Sodergren M. H. , Mangal N. , Wasan H. , Sadanandam A. , Balachandran V. P. , Jiao L. R. , Habib N. 
Published: August 2020

AbstractAdvances in surgery, peri-operative care and systemic chemotherapy have not significantly improved the prognosis of pancreatic cancer for several decades. Early clinical trials of immunotherapy have yielded disappointing results proposing other means by which the tumour microenvironment serves to decrease the immune response. Additionally, the emergence of various subtypes of pancreatic cancer has emerged as a factor for treatment responses with immunogenic subtypes carrying a better prognosis. Herein we discuss the reasons for the poor response to checkpoint inhibitors and outline a rationale why combination treatments are likely to be most effective. We review the therapies which could provide optimal synergistic effects to immunotherapy including chemotherapy, agents targeting the stroma, co-stimulatory molecules, vaccinations and methods of immunogenic tumour priming including radiofrequency ablation. Finally, we discuss reasons why peri-operative and in particular neoadjuvant combination treatments are likely to be most effective and should be considered for early clinical trials.
What is known about the role of rural-urban residency in relation to self-management in people affected by cancer who have completed primary treatment? A scoping review
Authors: Nelson David , McGonagle Ian , Jackson Christine , Kane Ros 
Published: August 2020

Abstract
Purpose
Despite wide acknowledgement of differences in levels of support and health outcomes between urban and rural areas, there is a lack of research that explicitly examines these differences in relation to self-management in people affected by cancer following treatment. This scoping review aimed to map the existing literature that examines self-management in people affected by cancer who were post-treatment from rural and urban areas.

Methods
Arksey and O’Malley’s framework for conducting a scoping review was utilised. Keyword searches were performed in the following: Academic Search Complete, CINAHL, MEDLINE, PsycINFO, Scopus and Web of Science. Supplementary searching activities were also conducted.

Results
A total of 438 articles were initially retrieved and 249 duplicates removed leaving 192 articles that were screened by title, abstract and full text. Nine met the eligibility criteria and were included in the review. They were published from 2011 to 2018 and conducted in the USA (n = 6), Australia (n = 2) and Canada (n = 1). None of the studies offered insight into self-managing cancer within a rural-urban context in the UK. Studies used qualitative (n = 4), mixed methods (n = 4) and quantitative designs (n = 1).

Conclusion
If rural and urban populations define their health in different ways as some of the extant literature suggests, then efforts to support self-management in both populations will need to be better informed by robust evidence given the increasing focus on patient-centred care. It is important to consider if residency can be a predictor of as well as a barrier or facilitator to self-management.
Targeting the immune milieu in gastrointestinal cancers
Authors: Turkes Fiona , Mencel Justin , Starling Naureen 
Published: August 2020

AbstractGastrointestinal (GI) cancers are among the most common and lethal solid tumors worldwide. Unlike in malignancies such as lung, renal and skin cancers, the activity of immunotherapeutic agents in GI cancers has, on the whole, been much less remarkable and do not apply to the majority. Furthermore, while incremental progress has been made and approvals for use of immune checkpoint inhibitors (ICIs) in specific subsets of patients with GI cancers are coming through, in a population of ‘all-comers’, it is frequently unclear as to who may benefit most due to the relative lack of reliable predictive biomarkers. For most patients with newly diagnosed advanced or metastatic GI cancer, the mainstay of treatment still involves chemotherapy and/or a targeted agent however, beyond the second-line this paradigm confers minimal patient benefit. Thus, current research efforts are concentrating on broadening the applicability of ICIs in GI cancers by combining them with agents designed to beneficially remodel the tumor microenvironment (TME) for more effective anti-cancer immunity with intention of improving patient outcomes. This review will discuss the currently approved ICIs available for the treatment of GI cancers, the strategies underway focusing on combining ICIs with agents that target the TME and touch on recent progress toward identification of predictors of sensitivity to immune checkpoint blockade in GI cancers.
Systemic treatment options for advanced biliary tract carcinoma
Authors: Xie Changqing , McGrath Nicole A. , Monge Bonilla Cecilia , Fu Jianyang 
Published: August 2020

AbstractAdvanced biliary tract cancers (BTC) include a diverse collection of rare and heterogenous tumors with poor prognosis. The combination of gemcitabine and cisplatin is the established first-line therapy for advanced BTC. There are no accepted standard treatments in the second line setting, though there are several ongoing clinical trials that implement chemotherapy as a therapeutic strategy. The understanding of the molecular landscape of BTC has offered hope of targeted therapies to the identified actionable genomic aberrations, such as FGFR2 gene fusions, mutations of IDH1/2, HER2, BRAC1/2 and BRAF. Pembigatinib has become the first approved targeted therapy for BTC with FGFR2 fusion or other rearrangements. Recent immunotherapy has opened new therapy avenues in BTC with pembrolizumab approved for either microsatellite instability high (MSI-H) or DNA mismatch repair deficient (dMMR) advanced solid tumors, including BTC. The combination of immunotherapy with other modalities is currently being evaluated in different clinical trials, since single agent immunotherapy appears to provide modest benefits in advanced BTC. In this review, we summarize the current status of treatment options, including systemic chemotherapy, targeted therapy, immunotherapy, and various combinations in advanced BTC.
An improved shear deformation theory for bending beams with symmetrically varying mechanical properties in the depth direction
Authors: Magnucki Krzysztof , Lewinski Jerzy , Magnucka-Blandzi Ewa 
Published: August 2020

AbstractThe paper is devoted to simply supported beams under three-point bending. Their mechanical properties symmetrically vary in the depth direction. The individual shear deformation theory for beams of such features is proposed. Based on the principle of stationary total potential energy the differential equations of equilibrium are obtained. The system of the equations is analytically solved, and the shear coefficients and deflections of example beams are calculated. The solution is compared with other analytical results obtained with the use of another deformation function. Moreover, the bending problem of these beams is also numerically studied using the finite element method. Results of analytical and numerical studies are presented in Figures and Tables.
Anticholinergic burden, oral hygiene practices, and oral hygiene status—cross-sectional findings from the Northern Finland Birth Cohort 1966
Authors: Tiisanoja Antti , Syrjälä Anna-Maija , Anttonen Vuokko , Ylöstalo Pekka 
Published: August 2020

Abstract
Objectives
To study the association between anticholinergic burden and oral hygiene practices and oral hygiene status among 46-year-old people.

Materials and methods
The study included 1945 participants from the Northern Finland Birth Cohort 1966 (NFBC1966), who had a complete dental status. The participants underwent clinical medical and dental examinations, and their medication data were gathered by combining self-reported drug use with information from the National Prescription Register. Anticholinergic burden was measured using nine previously published anticholinergic scales. Oral hygiene practices were assessed with toothbrushing frequency and oral hygiene status with the presence of visible dental plaque. Poisson regression with robust variance estimation and negative binomial regression models were used to estimate relative risks (RR).

Results
Thirty percent of the participants reported brushing their teeth twice a day and about 25% of their teeth had dental plaque on them. Fifteen percent of the participants used at least one anticholinergic drug or had an anticholinergic burden according to the nine anticholinergic scales. After adjustments for confounding factors, the RRs of anticholinergic burden varied between 0.95 and 1.11 for toothbrushing frequency. Anticholinergic burden (according to Anticholinergic Activity Scale, Anticholinergic Cognitive Burden, Chew’s scale) was associated statistically significantly with the number of teeth with dental plaque. For the three scales, RRs varied from 1.24 to 1.50.

Conclusions
Anticholinergic burden associated with poor oral hygiene.

Clinical relevance
The findings stress the importance of providing oral hygiene instructions and prophylactic measures to patients taking anticholinergic drugs.
Tuning hydrogen sorption properties of Pd by its alloying with Ru, Rh, and Pt: the study of binary alloys in concentrated alkaline media
Authors: Hubkowska K. , Czerwiński A. 
Published: August 2020

AbstractThe hydrogen electrosorption process was examined in 6 M KOH on Pd binary alloys, containing Rh, Ru, and Pt. Pd-alloys were electrochemically deposited on Au substrate. The electrodes were subjected to activation procedure—hydrogen pretreatment procedure (HPP) at first in 0.5 M H2SO4 and then in 6 M KOH. It was noticed that it was possible to achieve comparable reversibility of hydrogen electrosorption process in acid and in concentrated base. The obtained values of the α→β phase transition potential, hysteresis extent, and maximum hydrogen absorption capacity show good agreement with the data from acidic medium. The observed kinetics of hydrogen electrosorption were strongly hindered in concentrated alkaline media, whereas the influence of the electrolyte on the thermodynamic functions of hydrogen absorption is less pronounced.
Simple and effective neural-free soft-cluster embeddings for item cold-start recommendations
Authors: Puthiya Parambath Shameem A. , Chawla Sanjay 
Published: August 2020

AbstractRecommender systems are widely used in online platforms for easy exploration of personalized content. The best available recommendation algorithms are based on using the observed preference information among collaborating entities. A significant challenge in recommender system continues to be item cold-start recommendation: how to effectively recommend items with no observed or past preference information. Here we propose a two-stage algorithm based on soft clustering to provide an efficient solution to this problem. The crux of our approach lies in representing the items as soft-cluster embeddings in the space spanned by the side-information associated with the items. Though many item embedding approaches have been proposed for item cold-start recommendations in the past—and simple as they might appear—to the best of our knowledge, the approach based on soft-cluster embeddings has not been proposed in the research literature. Our experimental results on four benchmark datasets conclusively demonstrate that the proposed algorithm makes accurate recommendations in item cold-start settings compared to the state-of-the-art algorithms according to commonly used ranking metrics like Normalized Discounted Cumulative Gain (NDCG) and Mean Average Precision (MAP). The performance of our proposed algorithm on the MovieLens 20M dataset clearly demonstrates the scalability aspect of our algorithm compared to other popular algorithms. We also propose the metricCold Items Precision(CIP) to quantify the ability of a system to recommend cold-start items. CIP can be used in conjunction with relevance ranking metrics like NDCG and MAP to measure the effectiveness of the cold-start recommendation algorithm.
The keyword effect: A conceptual replication, effects on bias, and an optimization
Authors: Waldeyer Julia , Roelle Julian 
Published: August 2020

AbstractPrompting learners to generate keywords after a delay is a promising means to enhance relative judgment accuracy in learning from texts. However, to date, conceptual replications of the keyword effect without the involvement of the researcher who originally proposed it are still scarce. Furthermore, it is unclear whether generating delayed keywords could reduce bias and whether the benefits of generating delayed keywords could be optimized by having learners compare their keywords with expert ones. Against this background, we conducted an experiment with N = 109 university students who read four expository texts and then were randomly assigned to one of three experimental conditions: (a) Generation of keywords after reading, (b) generation of keywords after reading and a comparison with external standards in the form of expert keywords, (c) no keyword generation (control condition). We found that generating delayed keywords significantly increased relative accuracy but did not reduce bias. Furthermore, we found that the comparison with expert keywords enhanced relative accuracy beyond the established keyword effect. However, we also found that the comparison with expert keywords increased bias (here: underconfidence). Overall, these findings suggest that generating and comparing keywords is an effective means to enhance relative accuracy.
Einstellungen und Motivation bezogen auf kulturell-ethnisch heterogene Schülerinnen- und Schülergruppen und ihre Bedeutung für differenzielle Instruktion im Unterricht
Authors: Gebauer Miriam M. , McElvany Nele 
Published: August 2020

ZusammenfassungDer Beitrag widmet sich der Frage, inwieweit Aspekte der professionellen Kompetenz von Lehrkräften von Bedeutung für einen diversitätssensiblen Unterricht sind. Der Fokus liegt dabei auf Einstellungen und motivationaler Orientierung von Lehrkräften und untersucht die Bedeutsamkeit für einen differenziellen Unterricht im Kontext kulturell-ethnischer Diversität. Daten vonN = 250 Lehrkräften wurden anhand von Strukturgleichungsmodellen analysiert sowie geschlechtsspezifische Unterschiede anhand von Mehrgruppenstrukturgleichungsmodellen geprüft. Die Ergebnisse weisen darauf hin, dass Einstellungen und motivationale Orientierung von substanzieller Relevanz für eine diversitätssensible Unterrichtsgestaltung sind. Eine Prüfung geschlechtsspezifischer Differenzen für die gefundenen Zusammenhangsmuster zeigen nur geringe Unterschiede. Die Ergebnisse heben die Bedeutung der professionellen Kompetenz von Lehrkräften für diversitätssensiblen Unterricht hervor und werden hinsichtlich ihrer Implikation für Forschung und Praxis diskutiert.
A New Design for Friction Stir Spot Joining of Al Alloys and Carbon Fiber-Reinforced Composites
Authors: Bolouri Amir , Fotouhi Mohamad , Moseley William 
Published: August 2020

AbstractFriction stir spot welding (FSSW) has been recently developed to join dissimilar materials. However, the traditional requirement for a rotating tool consists of a pin and shoulder in FSSW leads to a complex joining process and unpredictable defects. In this study, a new static-shoulder design in FSSW was proposed and developed to join Al alloys to carbon fiber-reinforced polymer (CFRP) composites. The main joining parameters, including pin rotational speed, pin feed rate and pin plunge depth, were varied to investigate their effects on the joining temperature, materials interaction and the strength of joints. The pin rotational speed had the largest influence on the joining temperature. Lap shear tensile testing was conducted to evaluate the performance of the joints. The joints exhibited the ultimate lap shear force from 230 to 260 N. A brittle fracture occurred with the displacement-at-fracture load of 0.35-0.41 mm. Cross-sectional images revealed the creation of undulations on the surface of Al alloys in the joining zone. The undulations created a macro-mechanical interlocking bonding between the materials, which determined the performance of the joints. For a flat pin, by increasing the plunge depth from 1.25 to 1.30 mm, the undulation size increased from 0.21 to 0.26 mm, which can enhance the macro-mechanical interlocking bonding between Al alloys and CFRP and accordingly increased the ultimate shear force of the joints from 230 to 241 N. Use of a fluted pin significantly influenced the flow of the plasticized Al alloy which created pronounced undulations and large Al alloy spikes of 0.46 mm. These features seemed to establish an efficient macro-mechanical interlocking bonding, which resulted in a noticeable improvement in the performance of the joint. For a plunge depth of 1.30 mm, the ultimate shear force increased to 261 N using the fluted pin.