bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction for Progression Risk in Patients With COVID-19 Pneumonia: The CALL Score
Authors: Ji Dong , Zhang Dawei , Xu Jing , Chen Zhu , Yang Tieniu , Zhao Peng , Chen Guofeng , Cheng Gregory , Wang Yudong , Bi Jingfeng , Tan Lin , Lau George , Qin Enqiang 
Published: April 2020

Abstract

Background
We aimed to clarify high-risk factors for coronavirus disease 2019 (COVID-19) with multivariate analysis and establish a predictive model of disease progression to help clinicians better choose a therapeutic strategy.

Methods
All consecutive patients with COVID-19 admitted to Fuyang Second People’s Hospital or the Fifth Medical Center of Chinese PLA General Hospital between 20 January and 22 February 2020 were enrolled and their clinical data were retrospectively collected. Multivariate Cox regression was used to identify risk factors associated with progression, which were then were incorporated into a nomogram to establish a novel prediction scoring model. ROC was used to assess the performance of the model.

Results
Overall, 208 patients were divided into a stable group (n = 168, 80.8%) and a progressive group (n = 40,19.2%) based on whether their conditions worsened during hospitalization. Univariate and multivariate analyses showed that comorbidity, older age, lower lymphocyte count, and higher lactate dehydrogenase at presentation were independent high-risk factors for COVID-19 progression. Incorporating these 4 factors, the nomogram achieved good concordance indexes of .86 (95% confidence interval [CI], .81–.91) and well-fitted calibration curves. A novel scoring model, named as CALL, was established; its area under the ROC was .91 (95% CI, .86–.94). Using a cutoff of 6 points, the positive and negative predictive values were 50.7% (38.9–62.4%) and 98.5% (94.7–99.8%), respectively.

Conclusions
Using the CALL score model, clinicians can improve the therapeutic effect and reduce the mortality of COVID-19 with more accurate and efficient use of medical resources.
Effect of Throat Washings on Detection of 2019 Novel Coronavirus
Authors: Guo Wen-Liang , Jiang Qian , Ye Feng , Li Shao-Qiang , Hong Cheng , Chen Li-Yan , Li Shi-Yue 
Published: April 2020

Abstract
The 2019 novel coronavirus was detected in self-collected throat washings. The positive testing rate of throat washing was much higher than that of nasopharyngeal swabs. Throat washing is a promising candidate for 2019-nCoV screening and monitoring due to its noninvasiveness and reliability.
The Malleability Narrative in Entertainment and Social Media: Explaining Pathways to Happiness in Media Content
Authors: Vandenbosch Laura , Eggermont Steven 
Published: April 2020

Abstract
Media effects research has documented the prevalence of different ideals in media content, and their effects on media users. We developed a framework for the representation of such ideals, and that may increase our understanding of the effects media have on users' well-being. Drawing on cultural sociology, communication theory, and psychological literature, we introduce the malleability narrative of mediated ideals, described as “a collection of media representations of a variety of ideals that tend to be portrayed as within reach for anyone who is committed to pursuing his/her own self-interest.” The aim of the framework is to foster content analytical research on the occurrence of the malleability narrative in popular media and to stimulate audience research on interactions between media users and the malleability narrative in media, while taking account of different explanatory routes and the heterogeneity of the audience.
The perception of youth health centres’ friendliness: does it differ between immigrant and Swedish-Scandinavian youths?
Authors: Baroudi Mazen , San Sebastian Miguel , Hurtig Anna-Karin , Goicolea Isabel 
Published: April 2020

Abstract

Background
Ensuring a good quality service and equal access according to need for all young people is a key objective of the Swedish health system. The aim of this study was to explore youths’ perception of youth health centres’ (YHCs’) friendliness and to assess the differences in perception between immigrant and Swedish-Scandinavian youths.

Methods
All YHCs in the four northern counties in Sweden were invited (22 centres), and 20 agreed to participate. Overall, 1089 youths aged 16–25 years answered the youth-friendly health services-Sweden questionnaire between September 2016 and February 2017. Thirteen sub-domains of friendliness were identified and their scores were calculated. Multilevel analysis was used to examine the differences in perception between immigrant and Swedish-Scandinavian youths.

Results
Our sample consisted of 971 Swedish-Scandinavian youths (89.2%) and 118 immigrants (10.8%). Generally, both groups perceived the services to be very friendly. All 13 sub-domains were rated more than three in a four-point scale except for fear of exposure and parental support of psychosocial services. However, immigrant youths perceived YHCs less friendly than their counterparts, particularly regarding the domains of equity, respect, quality and parental support.

Conclusions
Our study suggests that even though youths perceived YHCs as highly friendly, there is a space for improvement regarding access to health care. Our findings highlight the importance of an open and culturally sensitive attitude of the staff and the need to engage parents and community as a key to improve immigrant youths’ accessibility to health care.
Measurements of the seismoelectric responses in a synthetic porous rock
Authors: Wang Jun , Zhu Zhenya , Gao Yongxin , Morgan Frank Dale , Hu Hengshan 
Published: April 2020

SUMMARY
Seismoelectric measurements are conducted with a synthetic porous rock sample to model an ocean exploration. Two kinds of seismoelectric coupling signals, that is, the interfacial EM wave signal and the coseismic electric signal, have been recorded by the electrodes buried inside a rock sample instead of those located in the fluid or in the solid region near the interface as performed in previous works. These seismoelectric signals are clearly observed and identified with a high signal-to-noise ratio. The characteristics of the measured interfacial EM wave and coseismic electric signals are analysed with the experimental data. We also simulate the seismoelectric conversion fields and make a comparison between the measured and simulated seismoelectric signals. The result shows that the simulated and measured signals match well for both the interfacial EM wave and the coseismic electric fields accompanying the fast P wave. Our results also show that the amplitudes of seismoelectric signals are in the order of tens to hundreds of microvolts with our experimental system. This confirms that the seismoelectric signals are measurable in the interior of the rocks with current measurement techniques, suggesting the seismoelectric measurement to be a potential method for studying characteristics of the material beneath the seafloor.
Patients With Combined Thermal and Intraabdominal Injuries: More Salvageable Than Not
Authors: Chang Jaimie , Hejna Emily , Fu Chih-Yuan , Bajani Francesco , Tatabe Leah , Schlanser Victoria , Kaminsky Matthew , Dennis Andrew , Starr Frederick , Messer Thomas , Poulakidas Stathis , Bokhari Faran 
Published: April 2020

Abstract
This study aims to better characterize the course and outcome of the uncommon subset of trauma patients with combined thermal and intraabdominal organ injuries. The National Trauma Data Bank was queried for burn patients with intraabdominal injury treated in all U.S. trauma centers from July 1, 2011 to June 30, 2015. General demographics, Glasgow coma scale (GCS), shock index (SI), Abbreviated Injury Scale (AIS) for burn, Injury Severity Score (ISS), blood transfusions, and abdominal surgery were evaluated. During the 5-year study period, there were 334 burn patients with intraabdominal injury, 39 (13.2%) of which received abdominal surgery. Burn patients who underwent operations had more severe injuries reflected by higher SI, AIS, ISS, blood transfusion, and worse outcomes including higher mortality, longer hospital and ICU length of stay, and more ventilator days compared to patients who did not undergo an operation. Nonsurvivors also exhibited more severe injuries, and a higher proportion received abdominal operation compared to survivors. Multivariate logistic regression analysis revealed that GCS on arrival, SI, AIS, ISS, blood transfusion, and abdominal operation to be independent risk factors for mortality. Propensity score matching to control covariables (mean age, systolic blood pressure on arrival, GCS on arrival, SI, ISS, time to operation, blood transfusion, and comorbidities) showed that of trauma patients who received abdominal operation, those with concomitant burn injury exhibited a higher rate of complications but no significant difference in mortality compared to those without burns, suggesting that patients with concomitant burns are not less salvageable than nonburned trauma patients.
A new species of Tantulocarida (Crustacea) parasitic on a deep-water cumacean host from the southwestern Atlantic, with a review of tantulocaridan host utilization, distribution, and diversity
Authors: Petrunina Alexandra S , Huys Rony 
Published: April 2020

AbstractTantulocaridans (Class Tantulocarida) are primarily known to parasitize copepods, tanaidaceans, and isopods while only single species have been recorded from amphipod, ostracod, and cumacean hosts. Examination of a collection of deep-water peracarids from the Campos Basin off northeastern Brazil resulted in the discovery of a tantulus larva attached to a juvenile Styloptocuma angustatum (Jones, 1984) (Cumacea, Nannastacidae), representing a new species and only the fifth record for this host group. The new species is provisionally assigned to the genus AphotocentorHuys, 1991 (Cumoniscidae) based on the proximally dilated terminal caudal ramus setae, the conspicuous polygonal surface ornamentation on the thoracic somites, the spinous processes around the posterior border of the abdomen, the dorsal abdominal surface pattern consisting of four continuous transverse lamellae, and the spinular ornamentation on the protopods of legs 2–6. The tantulus of A. kolbasovisp. nov. is characterized by its large body size (175 μm), disproportionally long cephalic shield, the presence of paired papillae on the midventral surface of the cephalon, and the unique swimming leg setal formula, displaying the highest number of setation elements ever reported for leg 1. Except for the asymmetrically arranged median pores, the new species exhibits the full complement of cephalic pores, including the anterior pore AV. Current classification, known stages, tantulus body length, and distribution of all valid tantulocaridan species are presented. Literature records of Tantulocarida, including host group/species and depth, as well as those based exclusively on tantulus stages from the temporary meiobenthos or unidentified stages from the meroplankton are summarized. The authenticity of recently reported tantulus larvae on the lysianassid amphipod Lepidepecreella debroyeriSchiaparelli, Alvaro, Kilgallen, Scinto & Lörz, 2015 from Terra Nova Bay (Ross Sea, Antarctica) is scrutinized. Tumour-like anomalies on the exoskeleton of planktonic copepods in the central Red Sea and around hydrothermal vent fluids off Taiwan have erroneously been attributed to tantulocaridan infections.
Changes in aboveground locomotion of a scansorial opossum associated to habitat fragmentation
Authors: Delciellos Ana Cláudia , Ribeiro Suzy Emidio , Prevedello Jayme Augusto , Vieira Marcus Vinícius 
Published: April 2020

AbstractHabitat fragmentation may affect animal movement patterns due to changes in intra- and interspecific interactions as well as in habitat quality and structure. Although the effects of habitat fragmentation on terrestrial movements are relatively well-known, it is unclear whether and how they affect aboveground locomotion of individuals. We compared aboveground locomotion of a Neotropical small mammal, the gray four-eyed opossum, Philander quica, between two forest fragments and two areas of continuous forest in the Brazilian Atlantic Forest. We 1) quantified support availability and tested for active selection of different support diameters and inclinations by individuals; and 2) compared support diameters and inclinations used (observed values) among areas and between males and females. Both males and females selected supports based on diameters and inclinations in forest fragments. In continuous forests sites, females selected supports based on diameters and inclinations, but males selected only support diameters. Frequency of support diameter use differed significantly between forest fragments and continuous forest sites and between males and females. Frequency of support inclination use differed significantly between areas only for females, and between sexes only in continuous forest sites. Sex-related differences in support selection and use are likely related to differences in body size and conflicting energetic and behavioral demands related to use of arboreal space. Site-related differences in aboveground movements likely reflect the effects of forest edges that result in increased use of thinner supports in forest fragments. These results complement our previous findings that habitat fragmentation reduces daily home ranges and increases the total amount of aboveground locomotion of P. quica, and provide a more thorough picture of how forest-dependent species are able to use and persist in small forest fragments.
Purple acid phosphatase 10c encodes a major acid phosphatase that regulates plant growth under phosphate-deficient conditions in rice
Authors: Deng Suren , Lu Linghong , Li Jingyi , Du Zezhen , Liu Tongtong , Li Wenjing , Xu Fangsen , Shi Lei , Shou Huixia , Wang Chuang 
Published: April 2020

AbstractWhilst constitutive overexpression of particular acid phosphatases (APases) can increase utilization of extracellular organic phosphate, negative effects are frequently observed in these transgenic plants under conditions of inorganic phosphate (Pi) sufficiency. In this study, we identified rice purple acid phosphatase 10c (OsPAP10c) as being a novel and major APase that exhibits activities associated both with the root surface and with secretion. Two constructs were used to generate the OsPAP10c-overexpression plants by driving its coding sequence with either a ubiquitin promoter (UP) or the OsPAP10c-native promoter (NP). Compared with the UP transgenic plants, lower expression levels and APase activities were observed in the NP plants. However, the UP and NP plants both showed a similar ability to degrade extracellular ATP and both promoted root growth. The growth performance and yield of the NP transgenic plants were better than the wild-type and UP plants in both hydroponic and field experiments irrespective of the level of Pi supply. Overexpression of APase by its native promoter therefore provides a potential way to improve crop production that might avoid increased APase activity in untargeted tissues and its inhibition of the growth of transgenic plants.
Highly Effective Model for Implementation of In-House Platelets in a Tertiary Veteran Hospital Setting Without a Trauma Center
Authors: Petersen Jeffrey M , Patel Vijal , Jhala Darshana 
Published: April 2020

Abstract

Background
Platelet products have a limited shelf life and are costly. Therefore, to balance clinical usage/availability and wastage in a tertiary hospital setting without a trauma center, an innovative system model was established. This system reduced wastage by transferring platelet unit approaching their expiration date to a nearby facility (with the same blood supplier and a trauma center) before expiration, when there is no anticipated need for the product at the original location.

Methods
A review of data to determine the degree of platelet wastage and wastage costs one year before implementation of this measure in October 2017 and one year after implementation of this measure.

Results
Since the implementation of this measure, no platelet units have expired on the shelf. In contrast, from October 2016 to October 2017, before implementation of platelet transfer, platelet products expired regularly.

Conclusion
This new system model is highly effective in maintaining platelet inventory without wastage.
GeV emission of gamma-ray binary with pulsar scenario
Authors: Xingxing Hu , Jumpei Takata , Qingwen Tang 
Published: April 2020

ABSTRACT
We study GeV emission from gamma-ray binaries by assuming that the compact object is a young pulsar. We assume that the relativistic unshocked pulsar wind with a Lorentz factor of 104–5 can produce the GeV emission by the inverse-Compton scattering process in the dense soft-photon field of the companion star. The travel distance of the unshocked pulsar wind that moves toward the observer depends on the orbital phase of the pulsar. We discuss that the orbital modulation of the GeV emission is a result of combination of the effects of the travel distance of the unshocked pulsar wind and of the anisotropic soft-photon field of the companion star. In this paper, we study how the effect of the travel distance of the unshocked pulsar wind affects to the orbital modulation of GeV emission. We apply our scenario to two gamma-ray binaries, LMC P3 and 4FGL J1405.1−6119. We find that with the suggested system parameters of LMC P3, the observed amplitude of the orbital modulation and the peak width are more consistent with the model light curve by taking into account the effect of the travel distance. For LMC P3, we analyse the GeV spectrum with 8-yr Fermi-LAT data and discuss the broadband emission process in X-ray to TeV energy bands. We predict a possible system geometry for 4FGL J1405.1−6119 by fitting the GeV light curve.
Observing flare stars below 100 MHz with the LWA
Authors: Davis Ivey , Taylor Greg , Dowell Jayce 
Published: April 2020

ABSTRACT
We observed the flare stars AD Leonis, Wolf 424, EQ Pegasi, EV Lacertae, and UV Ceti for nearly 135 h. These stars were observed between 63 and 83 MHz using the interferometry mode of the Long Wavelength Array. Given that emission from flare stars is typically circularly polarized, we used the condition that any significant detection present in Stokes I must also be present in Stokes V at the same time in order for us to consider it a possible flare. Following this, we made one marginal flare detection for the star EQ Pegasi. This flare had a flux density of 5.91 Jy in Stokes I and 5.13 Jy in Stokes V, corresponding to a brightness temperature 1.75 × 1016(r/r*)−2 K.
The Aphid X Chromosome Is a Dangerous Place for Functionally Important Genes: Diverse Evolution of Hemipteran Genomes Based on Chromosome-Level Assemblies
Authors: Li Yiyuan , Zhang Bo , Moran Nancy A 
Published: April 2020

Abstract
Different evolutionary forces shape gene content and sequence evolution on autosomes versus sex chromosomes. Location on a sex chromosome can favor male-beneficial or female-beneficial mutations depending on the sex determination system and selective pressure on different sexual morphs. An X0 sex determination can lead to autosomal enrichment of male-biased genes, as observed in some hemipteran insect species. Aphids share X0 sex determination; however, models predict the opposite pattern, due to their unusual life cycles, which alternate between all-female asexual generations and a single sexual generation. Predictions include enrichment of female-biased genes on autosomes and of male-biased genes on the X, in contrast to expectations for obligately sexual species. Robust tests of these models require chromosome-level genome assemblies for aphids and related hemipterans with X0 sex determination and obligate sexual reproduction. In this study, we built the first chromosome-level assembly of a psyllid, an aphid relative with X0 sex determination and obligate sexuality, and compared it with recently resolved chromosome-level assemblies of aphid genomes. Aphid and psyllid X chromosomes differ strikingly. In aphids, female-biased genes are strongly enriched on autosomes and male-biased genes are enriched on the X. In psyllids, male-biased genes are enriched on autosomes. Furthermore, functionally important gene categories of aphids are enriched on autosomes. Aphid X-linked genes and male-biased genes are under relaxed purifying selection, but gene content and order on the X is highly conserved, possibly reflecting constraints imposed by unique chromosomal mechanisms associated with the unusual aphid life cycle.
Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
Authors: Li Jiexin , Chen Zhuojia , Chen Feng , Xie Guoyou , Ling Yuyi , Peng Yanxi , Lin Yu , Luo Nan , Chiang Cheng-Ming , Wang Hongsheng 
Published: April 2020

Abstract
Studies on biological functions of N6-methyladenosine (m6A) modification in mRNA have drawn significant attention in recent years. Here we describe the construction and characterization of a CRISPR–Cas13b-based tool for targeted demethylation of specific mRNA. A fusion protein, named dm6ACRISPR, was created by linking a catalytically inactive Type VI-B Cas13 enzyme from Prevotella sp. P5–125 (dPspCas13b) to m6A demethylase AlkB homolog 5 (ALKBH5). dm6ACRISPR specifically demethylates m6A of targeted mRNA such as cytochrome b5 form A (CYB5A) to increase its mRNA stability. It can also demethylate β-catenin-encoding CTNNB1 mRNA that contains multiple m6A sites to trigger its translation. In addition, the dm6ACRISPR system incurs efficient demethylation of targeted epitranscriptome transcripts with limited off-target effects. Targeted demethylation of transcripts coding for oncoproteins such as epidermal growth factor receptor (EGFR) and MYC can suppress proliferation of cancer cells. Together, we provide a programmable and in vivo manipulation tool to study mRNA modification of specific genes and their related biological functions.
MusiteDeep: a deep-learning based webserver for protein post-translational modification site prediction and visualization
Authors: Wang Duolin , Liu Dongpeng , Yuchi Jiakang , He Fei , Jiang Yuexu , Cai Siteng , Li Jingyi , Xu Dong 
Published: April 2020

Abstract
MusiteDeep is an online resource providing a deep-learning framework for protein post-translational modification (PTM) site prediction and visualization. The predictor only uses protein sequences as input and no complex features are needed, which results in a real-time prediction for a large number of proteins. It takes less than three minutes to predict for 1000 sequences per PTM type. The output is presented at the amino acid level for the user-selected PTM types. The framework has been benchmarked and has demonstrated competitive performance in PTM site predictions by other researchers. In this webserver, we updated the previous framework by utilizing more advanced ensemble techniques, and providing prediction and visualization for multiple PTMs simultaneously for users to analyze potential PTM cross-talks directly. Besides prediction, users can interactively review the predicted PTM sites in the context of known PTM annotations and protein 3D structures through homology-based search. In addition, the server maintains a local database providing pre-processed PTM annotations from Uniport/Swiss-Prot for users to download. This database will be updated every three months. The MusiteDeep server is available at https://www.musite.net. The stand-alone tools for locally using MusiteDeep are available at https://github.com/duolinwang/MusiteDeep_web.