bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chest CT imaging characteristics of COVID-19 pneumonia in preschool children: a retrospective study
Authors: Li Yang , Cao Jianghui , Zhang Xiaolong , Liu Guangzhi , Wu Xiaxia , Wu Baolin 
Published: April 2020

Abstract
Background : Recently, the World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) outbreak a public health emergency of international concern. So far, however, limited data are available for children. Therefore, we aimed to investigate the clinical and chest CT imaging characteristics of COVID-19 in preschool children. Methods: From January 26, 2020 to February 20, 2020, the clinical and initial chest CT imaging data of eight preschool children with laboratory-confirmed COVID-19 from two hospitals were retrospectively collected. The chest CT imaging characteristics, including the distribution, shape, and density of lesions, and the pleural effusion, pleural changes, and enlarged lymph nodes were evaluated. Results: Two cases (25%) were classified as mild type, and they showed no obvious abnormal CT findings or minimal pleural thickening on the right side. Five cases (62.5%) were classified as moderate type. Among these patients, one case showed consolidation located in the subpleural region of the right upper lobe, with thickening in the adjacent pleura; one case showed multiple consolidation and ground-glass opacities (GGO) with blurry margins; one case displayed bronchial pneumonia-like changes in the left upper lobe; and two cases displayed asthmatic bronchitis-like changes. One case (12.5%) was classified as critical type and showed bronchial pneumonia-like changes in the bilateral lungs, presenting blurred and messy bilateral lung markings and multiple patchy shadows scattered along the lung markings with blurry margins. Conclusions: The chest CT findings of COVID-19 in preschool children are atypical and various. Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data.
First report of the root-knot nematode, Meloidogyne morocciensis infecting peach in Southern Brazil
Authors: Silva W. R. , Machaca-Calsin C. P. , Gomes C. B. 
Published: April 2020

Abstract
The peach tree (Prunus persica) is the third most cultivated temperate fruit species in Brazil. In August 2017, peach seedling plants showing symptoms of stunting and multiple galls in the roots were detected in the municipality of Pelotas, state of Rio Grande do Sul, Brazil. Samples of peach roots were collected and they were subsequently processed to obtain eggs and second-stage juveniles (J2), to determine the number of nematodes per gram of roots and to proceed with morphological studies. Additionally, individual females were extracted from the peach roots and submitted to Meloidogyne species identification by electrophoresis using α-esterase (Est) and malate dehydrogenase (Mdh) phenotypes and perineal pattern. The nematode population density in the samples was 283 eggs + J2s per gram of fresh roots. The polymorphism analysis revealed the A3N1 phenotype, typical to Meloidogyne morocciensis. Perineal patterns of females showed oval squared shapes, with moderately high to high dorsal arches, streaks widely separated, generally continuous, sometimes broken; the phasmids were separate by 29.3 μm (25.43-31.94 μm), similar to M. arenaria and M. incognita, as observed by Hammah and Hirschmann (1990). The second-stage juveniles had the following morphometric characters: L = 389.3 ± 3.8 (377.5-425.1) μm, stylet = 13.9 ± 0.2 (12.7-14.9) μm, DGO = 3.6 ± 0.1 (3.3-4.2) μm, tail length 47.5 ± 0.6 (45.3-48.9) µm, hyaline tail terminus = 14.1 ± 0.3 (12.5-17.0) µm, a = 25.6 ± 0.4 (23.8-28.8) µm and c = 8.6 ± 0.1 (8.0-9.3). The known SCAR marker obtained for M. arenaria is the same as that amplified for M. morocciensis. Under greenhouse conditions, peach plants seedlings inoculated with 1,000 eggs (Pi) with M. morocciensis were evaluated 28 days after inoculation compared to non-inoculated plants. The inoculated peach plants showed a mean of 338 galls per root system, and a nematode reproduction factor of 10.3. Besides this plants exhibited a reduction in fresh weight of shoots and roots compared to the non-inoculated plants. These results confirm M. morocciensis pathogenicity on P. persica.
Modeling total microcystin production by Microcystis aeruginosa using multiple regression
Authors: Aragão Marianna Correia , dos Reis Kelly Cristina , Souza Allan Clemente , Rocha Maria Aparecida Melo , Capelo Neto Jose 
Published: April 2020

Abstract
Microcystis sp. is one of the most studied genus of cyanobacteria worldwide. Once it has been identified in raw water, frequent analyses of cell density and toxic metabolites (microcystins) are recommended at the water treatment plants. However, both analytical procedures are highly time-consuming and labor-intensive, allowing the potentially contaminated finished water to reach customers. The identification of easily measurable parameters related to toxin production, preferably by on-line equipment, would mitigate this issue and help water companies to improve water safety and decrease operating costs. However, these devices still have precision limitations and need efficient mathematical models for converting light signals into cyanobacteria densities or cyanotoxin concentrations. In this scenario, this research aimed to develop a mathematical correlation between microcystin production and cell age and density, chlorophyll-a, pheophytin and phycocyanin in a Microcystis aeruginosa culture using a multiple linear regression model. Despite the significant correlation (p &lt; 0.05) found between all the variables and total microcystin, a simplified and precise model (Adjusted R2 = 0.824) involving only phycocyanin and pheophytin concentrations was developed in order to provide an initial attempt to easily and cheaply predict microcystin concentration in raw water.
Development of GIS-based Python scripts to calculate a water surface profile on a landscape for wetlands decision-making
Authors: Wang Zhentao , Trauth Kathleen M. 
Published: April 2020

Abstract
Wetlands provide many benefits for humans and the natural environment, but land-use changes have reduced their number and areal extent. Interest has grown in examining the landscape to determine those locations where, with minimal effort, it might be possible to develop a mitigation wetland – a location with sufficient water over a sufficient period of time to develop and maintain wetland functioning. This paper proposes a methodology to support the examination of the landscape for mitigation purposes through the application of open channel hydraulics principles to flow over a landscape. The methodology is part of a larger research effort ultimately combining hydrology and hydraulics, along with the landscape processes of infiltration and evapotranspiration, to perform a water balance assessment. Specifically, the methodology is implemented through readily available geographic information system tools along with Python scripts written for this study. The Python scripts automatically extract landscape characteristics from a digital elevation model and calculate hydraulic parameters that are used to determine water surface profiles using the Modified Euler's method. Multiple tests show that the script accurately produces profiles of flow between depressions over a landscape. Such determinations are the first step in understanding where water might exist on the surface to support mitigation wetland functions.
Nifurtimox Hampered the Progression of Astroglioma In vivo Via Manipulating the AKT-GSK3β axis
Authors: Zhang Qiuxia , Chen Zhenshuai , Yuan Wei , Tang Yu-Qing , Zhu Jiangli , Wu Wentao , Ren Hongguang , Wang Hui , Zheng Weiyi , Zhang Zhongjian , Kong Eryan 
Published: April 2020

Background:
Astroglioma, one major form of brain tumors, has remained principalAstroglioma, one major form of brain tumors, has remained
principally tough to handle for decades, due to the complexity of tumor pathology and
the poor response to chemo- and radio-therapies.ly tough
to handle for decades, due to the complexity of tumor pathology and the poor response
to chemo- and radio-therapies. Our previous study demonstrated that nifurtimox could
regulate the signaling axis of AKT-GSK3β in various tumor types including the
astroglioma U251 cells. Intriguingly, earlier case studies suggested that nifurtimox could
possibly permeate the blood brain barrier and arrest neuroblastoma in the brain. These
observations jointly encouraged us to explore whether nifurtimox would hinder the
growth of astroglioma in vivo. Our results exhibited that nifurtimox could competently
hinder the development of astroglioma in the mouse brain as compared to
temozolomide, the first line of drug for brain tumors. Meanwhile the surviving rate, as
well as the body-weight was dramatically upregulated upon nifurtimox treatment, as
compared to that of temozolomide. These findings offered nifurtimox as a better
alternative drug in treating astroglioma in vivo. Persistently, the manipulation of the
signaling axis of AKT-GSK3β in astroglioma was found in line with earlier findings in
neuroblastoma when treated with nifurtimox.

Methods:
Our previous study demonstrated that nifurtimox could regulate the signaling
axis of AKT-GSK3β in various tumor types including the astroglioma U251 cells.
Intriguingly, earlier case studies suggested that nifurtimox could possibly permeate the
blood brain barrier and arrest neuroblastoma in the brain. These observations jointly
encouraged us to explore whether nifurtimox would hinder the growth of astroglioma in
vivo.

Results:
Our results exhibited that nifurtimox could competently hinder the development
of astroglioma in the mouse brain as compared to temozolomide, the first line of drug for
brain tumors. Meanwhile the surviving rate, as well as the body-weight was dramatically
upregulated upon nifurtimox treatment, as compared to that of temozolomide. These
findings offered nifurtimox as a better alternative drug in treating astroglioma in vivo.

Conclusion:
Persistently, the manipulation of the signaling axis of AKT-GSK3β in
astroglioma was found in line with earlier findings in neuroblastoma when treated with
nifurtimox.
Future Oncotargets: Targeting Overexpressed Conserved Protein Targets in Androgen Independent Prostate Cancer Cell Lines
Authors: Baig Abdul M. , Rana Zohaib , Mannan Mohammad M. , Khaleeq Areeba , Nazim Fizza , Katyara Preet , Abbas Farhat 
Published: April 2020

Background:
Targeting evolutionarily conserved proteins in malignant cells and the adapter proteins
involved in signalling that generates from such proteins may play a cardinal role in the selection of anti-cancer
drugs. Drugs targeting these proteins could be of importance in developing anti-cancer drugs.

Objectives:
We inferred that drugs like loperamide and promethazine that act as antagonists of proteins conserved
in cancer cells like voltage-gated Calcium channels (Cav), Calmodulin (CaM) and drug efflux (ABCB1)
pump may have the potential to be re-purposed as an anti-cancer agent in Prostate Cancer (PCa).

Methods:
Growth and cytotoxic assays were performed by selecting loperamide and promethazine to target Cav,
CaM and drug efflux (ABCB1) pumps to elucidate their effects on androgen-independent PC3 and DU145 PCa
cell lines.

Results:
We show that loperamide and promethazine in doses of 80-100μg/ml exert oncocidal effects when
tested in DU145 and PC3 cell lines. Diphenhydramine, which shares its targets with promethazine, except the
CaM, failed to exhibit oncocidal effects.

Conclusion:
Anti-cancer effects can be of significance if structural analogues of loperamide and promethazine
that specifically target Cav, CaM and ABCB1 drug efflux pumps can be synthesized, or these two drugs could
be re-purposed after human trials in PCa.
TIME SERIES ANALYSIS: FORECASTING SALES PERIODS IN WHOLESALE SYSTEMS
Authors: Predić Bratislav , Radosavljević Nevena , Stojčić Aleksandar 
Published: April 2020

The main goal of time series analysis is explaining the correlation and the main features of the data in chronological order by using appropriate statistical models. It is being used in various aspects of life and work, as well as in forecasting future product demands, service demands, etc. The most common type of time series data is the one whose observations are taken in equally distributed time intervals (daily, weekly, monthly, etc.). However, in this paper, we analyze a different kind of time series which represents product purchase moments. Thus, since there are not any regular observation periods, this irregular time series must be transformed in some way before traditional methods of analysis can be applied. After the data transformation is complete, the next step is modeling the nonstationary time series using commonly known models such as ARIMA and PNBD, which have been chosen for their fairly easy and successful forecasting processes. The goal of this analysis is timely product advertising to a customer in order to increase sales.Unlike some other models that consider the relationship between two or more different phenomena, time series models, including ARIMA, Pareto/NBD and Poisson models, examine the impact of historical values of a single phenomenon on its present and future value. This approach enables the study of the behavior of a given phenomenon over time and produces good results, especially if a large amount of historical data is available.
CEO Tax Effects on Acquisition Structure and Value
Authors: Hanlon Michelle , Verdi Rodrigo S. , Yost Benjamin P. 
Published: April 2020

ABSTRACT
We hypothesize that prior evidence of target shareholder capital gains tax liabilities affecting acquisition features is driven by the tax liabilities of the target firm CEO. To test this, we estimate CEOs' capital gains tax liabilities for a large sample of acquisitions and examine the effects of such liabilities on acquisition outcomes. Results indicate that the previously documented positive relations between shareholder-level capital gains tax rates and (1) the likelihood of a nontaxable acquisition (Ayers, Lefanowicz, and Robinson 2004), and (2) acquisition premiums (Ayers, Lefanowicz, and Robinson 2003) are largely driven by CEO tax effects. We also find evidence consistent with (1) CEOs' tax incentives leading to potential agency conflicts under certain conditions, and (2) acquisition structure or premium being adjusted in response to CEOs' taxes depending on the alternatives available to the acquirer. Our study contributes to our understanding of what and whose taxes affect acquisition structure and value.
JEL Classifications: G34:, H24; H32: J33; M52.
The Folly of Forecasting: The Effects of a Disaggregated Demand Forecasting System on Forecast Error, Forecast Positive Bias, and Inventory Levels
Authors: Brüggen Alexander , Grabner Isabella , Sedatole Karen L. 
Published: April 2020

ABSTRACT
Periodic demand forecasts are the primary planning and coordination mechanism within organizations. Because most demand forecasts incorporate human judgment, they are subject to both unintentional error and intentional opportunistic bias. We examine whether a disaggregation of the forecast into various sources of demand reduces forecast error and bias. Using proprietary data from a manufacturing organization, we find that absolute demand forecast error declines following the implementation of a disaggregated forecast system. We also find a favorable effect of forecast disaggregation on finished goods inventory without a corresponding increase in costly production plan changes. We further document a decline in positive forecast bias, except for products whose production is limited owing to scarce production resources. This implies that disaggregation alone is not sufficient to overcome heightened incentives of self-interested sales managers to positively bias the forecast for the very products that an organization would like to avoid tying up in inventory.
Data Availability: Data are the property of the research partner and may not be redistributed by the authors.
SoLoMo marketing as a global tool for enhancing awareness of eco-innovations in Slovak business environment
Authors: Zaušková Anna , Rezníčková Monika 
Published: April 2020

Research background: Thanks to globalization, a number of new possibilities and available technological solutions have emerged, thus modernizing marketing communication activities and bringing a broad spectrum of business opportunities to the single European market which enterprises may use to their benefits. Changes are much more frequent than ever before. Therefore, it is important to search for innovative solutions which contribute to more effective fulfillment of goals, generate positive changes or increase value for customers and as a matter of fact, enhance innovative performance and business competitiveness.
Purpose of the article: The paper deals with the presentation of eco-innovations in the business environment using creative tools of online marketing communication. Eco-innovations are a phenomenon which is present across all business activities and processes including marketing communication. The authors study such marketing activities of businesses which are part of corporate social responsibility, generate business growth and finally help to improve the global environment. The authors also present the partial results of their own quantitative marketing research in order to describe the application of SoLoMo marketing tools in the presentation of eco-innovations in the Slovak business environment.
Methods: The authors prepared a standardized questionnaire on a sample of 300 Slovak businesses. To test the dependence or independence of the variables, a Chi-squared test and Fisher´s exact test were used.
Findings & Value added: Despite the generally growing trend of the use of mod-ern online marketing tools, the research showed that Slovak businesses do not inform sufficiently about their eco-innovation activities, do not address all prospective target groups and do not make enough effort to enhance environmental awareness of the wider public. The results of the research will serve as basic information for the following specific studies, the main aim of which is to spread awareness among consumers and to eventually provide them with practical recommendations. In addition, the given theoretical part of the paper represents a valuable summary of information about the modern SoLoMo marketing concept while providing a detailed overview of other relevant research studies in the given field. Therefore, the paper portrays an overview of opportunities for the implementation of digital tools of marketing communication in small, medium-sized and large enterprises.
O Cotidiano do enfermeiro no Centro de Atenção Psicossocial Álcool e Drogas III sob a perspectiva da organização do trabalho.
Authors: Pinto Christina Otaviano , Alves Marcelo da Silva , Thofehrn Maira Buss , Gondim Giulia 
Published: April 2020

Objetivo: compreender a organização do trabalho da equipe de enfermagem em um Centro de Atenção Psicossocial Álcool e Drogas III. Métodos: estudo qualitativo, descritivo e exploratório desenvolvido na Zona da Mata Mineira. Os dados foram coletados de abril a novembro de 2016 com 10 profissionais da equipe de enfermagem através de entrevistas semiestruturadas. A análise dos dados foi realizada por meio da análise de conteúdo de Minayo. Resultados: emergiram as seguintes categorias: a) organização do trabalho e ações da equipe de enfermagem no CAPS ad III e b) os descaminhos de uma prática pensada e vivida e “a profissão do jeito que tem que ser”. O estudo revelou que a organização do trabalho de enfermagem no CAPS ad III, ainda reproduz o modelo tradicional, que dificulta a expressão da subjetividade e da criatividade dos trabalhadores e usuários. Considerações finais: o enfermeiro é um importante protagonista na transformação da organização do trabalho da enfermagem, pois exerce a gestão do cuidado, entretanto precisa incentivar novas propostas com articulação do saber/fazer que integrem todos os profissionais.
Palavras-chave: Enfermagem, Saúde Mental, Organização do trabalho, Serviços comunitários de saúde mental.
Eficácia de fungicidas para o controle da ferrugem asiática da soja em Dourados – MS na safra 2016/17
Authors: Souza Paulo Henrique Nascimento de , Dias Anderson Dos Santos , Gavassoni Walber Luiz , Bacchi Lilian Maria Arruda , Pontim Bruno Cézar Alvaro , Silva Ramom Alexandre Lopes da 
Published: April 2020

O aparecimento de isolados de Phakopsora pachyrhizi resistentes a fungicidas, tem gerado preocupação com a manutenção da eficiência das atuais tecnologias de controle. O objetivo deste trabalho foi avaliar a eficiência de formulações comerciais mistas fungicidas no controle da ferrugem asiática da soja no município de Dourados – MS, safra 2016/17. Foram testados nove programas de controle fungicida: azoxistrobina + benzovindiflupir, azoxistrobina + ciproconazol, azoxistrobina + mancozeb, picoxistrobina + benzovindiflupir, picoxistrobina + ciproconazol, piraclostrobina + epoxiconazol, piraclostrobina + epoxiconazol + fluxapiroxade, piraclostrobina + fluxapiroxade e picoxistrobina + tebuconazol e uma testemunha sem aplicação. O experimento foi conduzido em blocos casualizados com quatro repetições, utilizando a cultivar CD 2620 IPRO. Foram realizadas quatro aplicações com auxílio de pulverizador costal pressurizado com CO2, em parcelas delimitadas de 18,9 m². Análises de área foliar lesionada revelaram que as formulações picoxistrobina + benzovindiflupir e piraclostrobina + epoxiconazol + fluxapiroxade proporcionaram o melhor controle da ferrugem da soja. Contudo, todos os fungicidas apresentaram eficiência abaixo de 80% para redução dos sintomas provenientes da doença. Com exceção de piraclostrobina + epoxiconazol, os demais fungicidas resultaram em redução da área foliar lesionada e incremento na produtividade. Observou-se uma redução da eficiência das formulações a base de inibidores da succinato desidrogenase (ISDHs) em relação aos primeiros anos de uso da formulação. Os resultados encontrados demonstram a necessidade da adoção de estratégias que visem o manejo da resistência do fungo P. Pachyrhizi e que contribuam na recuperação da eficiência de controle proporcionado pelos fungicidas.
The 2007 caldera collapse at Piton de la Fournaise: new insights from multi-temporal structure-from-motion
Authors: Derrien Allan , Peltier Aline , Villeneuve Nicolas , Staudacher Thomas 
Published: April 2020

We produced new multi-temporal Digital Elevation Models (DEMs) of the April 2007 summit collapse at Piton de la Fournaise from previously unused aerial photographs. This dataset revealed the precise temporal evolution of collapsed volume and caldera morphological changes. Four days after the onset of an eruption at an unusually low elevation, the summit started to collapse (20:48 UTC April 5th). During the first 30 hours, collapsing was relatively fast (840 m3 s-1 average), and continued for at least the following 12 days, at a slower rate (46 m3 s-1 average). On April 19th, the collapse reached 96% of its final volume, while the remaining 4% were probably attained by May 1st (end of lava emission at the vent). The post-collapse hydrothermal activity in the caldera is closely associated with the main ring faults evidenced as active during the collapse, which are now preferential paths for fluids to reach the surface.
Fragmente und Ruinen
Authors: Latifi Kaltërina 
Published: April 2020

Abstract
T.S. Eliot’s The Waste Land speaks of a fragmentary world and, in itself, amounts to an epitome of fragmentation. This is mainly due to the last ‘stanza’ of the poem and is explicitly demonstrated in line 427, in which ‘fragments’ and ‘ruins’ are related to each other. This poetological analysis examines this very correlation against the backdrop of an earlier handwritten draft of the poem; it assesses variants of its translation, considers thematic contexts, and offers a detailed philologically-based interpretation of this iconic finale to Eliot’s quintessential contribution to literary modernism.