bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Case of Central Diabetes Incipidus Due to Post Pituitary Gland Agenesis: A Case Report
Authors: Mirhosseini Naser Ali , Tahghighi Fatemeh , Nafisi Moghadam Reza 
Published: October 2020

Background:Diabetes insipidus (DI) is a syndrome that begins with polyuria and is often associated with polydipsia. Three significant differential diagnosis are important to consider in evaluating the causes of polyuria, including primary polydipsia, diabetes mellitus, and diabetes insipidus. In diabetes incipidus, ADH hormone is not synthesized and secreted in Central DI or the hormone has lost its function in the renal tubules in nephrogenic DI type.
Case presentation:The patient was a 5.5 year-old-boy with polyurea and polydipsia from the beginning of the infancy. The patient had the serum osmolality of 277 mOsm/kg with the 24 hours urine volume of 4500 cc and urine osmolality of 200 mOsm/kg. The patient underwent water deprivation test for 12 hours. After administration of 20 μg of desmopressin spray, the urine osmolality increased to 720 mOsm/kg. Central diabetes insipidus was diagnosed. There was posterior hypophyseal agenesis in the brain MRI.
Conclusion: The above patient seemed to be one of the rare cases of autosomal recessive central DI that became symptomatic with polyuria and polydipsia from the early days of life. This rare and interesting case had isolated posterior pituitary agenesis. Desmopressin treatment resolved the patient's complaints. The patient was asymptomatic, and had normal growth in one year follow up.
Revisión de la discusión actual sobre la Covid-19 en el ámbito del pensamiento social
Authors: Maya-Ambía Carlos J. 
Published: October 2020

El artículo analiza la discusión más reciente sobre la Covid-19 por parte de pensadores sociales de diversos países con el fin de aclarar algunas importantes preguntas acerca de las causas, los efectos y las perspectivas de la pandemia. La revisión realizada muestra que la globalización neoliberal ha facilitado la aparición de la pandemia y ha mermado la capacidad de los Estados nacionales para enfrentar el problema. Lo primero, porque tal globalización ha impulsado la destrucción de la biodiversidad. Lo segundo, porque las políticas neoliberales han debilitado durante años al sector salud, incluso en los países de mayor desarrollo. Es por ello que la única forma de evitar futuras pandemias con efectos como los que estamos presenciando es cambiar radicalmente nuestros patrones de producción y de consumo, respetando a la naturaleza y frenando su explotación irresponsable. En el texto se esbozan los escenarios posibles en el futuro, de acuerdo con tres tipos de posturas, las pesimistas, las optimistas y las cautelosas, todas ellas con fundamentos que merecen ser discutidos. Finalmente, se presentan los aprendizajes que ha traído la pandemia y que deben tomarse en consideración antes de emprender cualquier intento de modelar el futuro.
En el texto se esbozan los escenarios posibles en el futuro, de acuerdo con tres tipos de posturas, las pesimistas, las optimistas y las cautelosas. Todas ellas con fundamentos que merecen ser discutidos. Finalmente se presentan los aprendizajes que ha traído la pandemia y que deben tomarse en consideración antes de emprender cualquier intento de modelar el futuro.
The Use of Teaching Media in Arabic Language Teaching During Covid-19 Pandemic
Authors: Ahmadi Ahmadi , Ilmiani Aulia Mustika 
Published: October 2020

The characteristic of Arabic Language which is unique and different compared to other foreign languages, has become certain issue for academic society, especially with this actual condition of COVID-19, it gives impact to both teachers and students. In university level, more specifically, in order to maintain teaching – learning process to be held, various kind of media are used to support the teaching and learning activities. This research aims for exploring and describing Arabic language teaching – learning online activities in IAIN Palangka Raya using qualitative method and case study. Data collecting methods used in this research are observations, interview and documentation. Research result shows that Arabic language teaching – learning online activities in IAIN Palangka Raya adopting online technology with platforms which based on social media and e-learning application. Those platforms are categorized into three: 1) WhatsApp Group, used for intensive communications between teacher and students related to teaching – learning activities; 2) Google Classroom, used for collecting assignments; and 3) Zoom Cloud Meeting, used for audio-visual media for learning topics which need significant explanation. These medias are used after consideration on ease of accessibility, hardware compatibility, communication features, process and cost needed to use them. The findings of this research describe that Arabic language teaching – learning online activities in IAIN Palangka Raya collaborate those three aforementioned applications so that creativity, innovation and motivation are growing even during Covid-19 pandemic situation.
Health, Safety, and Environment Operational Excellence through Full Utilization of Intelligent Field
Authors: Yateem Karam , Al Muailu Husain Ali , Gomaa Mohammed E. , Ayoola Olakunle T. 
Published: October 2020

Summary
Working in the oil industry comes with unique challenges and risks, and so extra precautions and safety measures coupled with strict environmental compliance must be applied. Contrary to the common belief that strict safety enforcement could hinder smooth operations, the deployment of new technologies and enhanced solutions of processes has enabled operational excellence (OE) and improved safety performance. In this paper, we demonstrate health, safety, and environment performance improvement through implementing two main initiatives:
The first category has initiatives that require less intervention or personnel; for example, the deployment of cableless pressure sensors or permanent monitoring systems in key wells to ensure continuous real-time pressure data to monitor reservoir pressure. The second category has initiatives that mitigate traditional health, safety, and environment risks; for example, through use of multiphase flow meters (MPFMs) to collect accurate and continuous flow measurements instead of traditional well testing.
Optimizing operations costs while maintaining a high-level of safety is achieved through a dedicated team working in a state-of-the-art Production Operations Surveillance Hub (POSH), which enables the monitoring of wells in real time, making production optimization decisions, and ensuring a high level of well integrity via close monitoring of wells and assets.
Consideration of Backreaming in Vertical Wells Closure Modeling in Salt Rock
Authors: Paranhos Sobrinho E. S. , Escarpini Filho R. S. , Lages E. N. , Anjos J. L. R. , Almeida L. F. M. , Gonçalves C. 
Published: October 2020

Summary
The mobility of salt rocks may cause problems, such as stuck pipe, high torque, casing collapse, and hole closure, promoting enormous losses in different areas. The drilling mud weight generates a hydrostatic pressure that serves as a counterpressure to the displacement of the salt. Sometimes this measure is not enough, leading to the backreaming operation, which reconditions the diameter of the wellbore to its original state. Given the importance of backreaming during drilling operations in salt rocks, its incorporation into computational tools is necessary. Through the finite element method (FEM), we developed a program to identify and simulate the effects of the backreaming operations in vertical wells in the presence of salt layers. We proposed a simulator that associates 1D axisymmetric multilayers with unit thickness through a coupling strategy between them, considering a lesser number of degrees of freedom when compared to conventional 2D modeling. We checked the performance of multilayers strategy when compared with 2D axisymmetric modeling of the hole closure problem in the commercial software ABAQUS® (Dassault Systèmes, Vélizy-Villacoublay, France); for the radial displacement histories, the multilayer strategy presented similarity with ABAQUS for cases that consider interaction, with the advantage of a low computational cost provided by the 1D formulation. We demonstrated the modeling of backreaming through the proposed tool.
A blended eHealth intervention for insomnia following acquired brain injury: study protocol for a randomized controlled trial
Authors: Ford Marthe , Geurtsen Gert J. , Groet Erny , Bennekom Coen A.M. Van , Someren Eus J.W. Van 
Published: October 2020

Abstract
Background: Up to a third of stroke patients and patients with traumatic brain injury suffer from insomnia, including problems to fall asleep or stay asleep at night. Insomnia may exacerbate other brain damage-related problems, for example regarding cognitive functioning and emotional well-being, may lead to poorer quality of life, and may complicate recovery processes. Cognitive behavioral therapy for insomnia, delivered face-to-face or online, is found to be effective in the general population. However, despite the high prevalence and serious consequences of insomnia following acquired brain injury, studies on the efficacy of face-to-face cognitive behavioral treatment in this population are scarce, and this applies even more for studies on online cognitive behavioral therapy. Therefore, this study aims to evaluate the efficacy of a newly developed guided online cognitive behavioral therapy for insomnia following acquired brain injury.Methods: A multicenter, prospective, randomized, open-label, blinded end point study (PROBE) will be conducted, in which 48 patients diagnosed with stroke or traumatic brain injury, and insomnia will be randomly allocated to the online cognitive behavioral therapy for insomnia treatment group or the treatment as usual group. The treatment consists of 6 online cognitive behavioral therapy sessions given on a weekly basis and personalized feedback after each session, combined with 2 face-to-face sessions. Outcomes will be assessed at baseline, immediately after the intervention period and at 6 weeks follow up. The primary outcome is the insomnia severity assessed with the insomnia severity index. Secondary outcome measures include sleep quality, sleep features derived from the sleep diary, fatigue, anxiety and depression, subjective cognitive functioning and societal participation.Discussion: This study will provide insight on the efficacy of online cognitive behavioral therapy for insomnia following stroke and traumatic brain injury.Trial Register: Netherlands Trial Register, NTR7082, 12 March 2018
Triple therapy combined with ventriculoperitoneal shunts can improve neurological function and shorten hospitalization time in non-HIV cryptococcal meningitis patients with increased intracranial pressure
Authors: Li Min , Liu Jia , Deng Xuhui , Gan Qingzhou , Wang Yijie , Xu Xiaofeng , Jiang Ying , Peng Fuhua 
Published: October 2020

Abstract
Background: Raised intracranial pressure (ICP) and insufficient antifungal regimens are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole, 5-flucytosine (5-FC) plus ventriculoperitoneal shunts (VPS) is superior to AmB, 5-FC, fluconazole plus intermittent lumbar puncture in induction therapy in non-HIV CM patients with increased ICP.Methods: We reviewed 66 clinical records from non-HIV CM patients with increased ICP. The demographic and clinical characteristics, BMRC staging, cerebrospinal ﬂuid proﬁles (CSF), brain magnetic resonance imaging, treatment, and outcomes of these individuals were retrospectively analyzed. All non-HIV CM patients with increased ICP (≥ 25 cmH2O) were divided into two groups, including 27 patients treated with triple antifungal agents and 39 patients treated with the same triple therapy plus VPS. Results: Triple therapy plus VPS group had more satisfactory outcomes, and more CSF sterilization at 10 weeks follow-up,lower CSF opening pressure, lower BMRC staging scores one week after VPS, less CSF C. neoformans counts and CSF culture positive. Patients in triple therapy plus VPS group got the improvement in neurological function circumstances evaluated by comparing the BMRC staging before and after VPS. These patients had shorter hospital stay.Conclusions: Triple antifungal agents combined with VPS can effectively reduce ICP, have faster rate of clearance of C. neoformans counts, more improved neurological function, shorten hospitalization time and better outcomes in non-HIV CM patients with increased ICP. Our study indicated that triple therapy plus early VPS is maybe the optimal treatment for non-HIV CM patients with increased ICP.
Changing trends of birth weight with maternal age: a cross-sectional study in Xi'an city of Northwestern China
Authors: Wang Shanshan , Yang Liren , Shang Li , Yang Wenfang , Qi Cuifang , Huang Liyan , Xie Guilan , Wang Ruiqi , Chung Mei Chun 
Published: October 2020

Abstract
Background: Most studies have shown that maternal age is associated with birth weight. However, the specific relationship between each additional year of maternal age and birth weight remains unclear. The study aimed to analyze the specific association between maternal age and birth weight.Methods: Raw data for all live births from 2015 to 2018 were obtained from the Medical Birth Registry of Xi’an, China. A total of 490143 mother-child pairs with full-term singleton live births and the maternal age ranging from 20 to 40 years old were included in our study. Birth weight, gestational age, neonatal birth date, maternal birth date, residence and ethnicity were collected. Generalized additive model and two-piece wise linear regression model were used to analyze the specific relationships between maternal age and birth weight, risk of low birth weight, and risk of macrosomia.Results: The relationships between maternal age and birth weight, risk of low birth weight, and risk of macrosomia were nonlinear. Birth weight increased 16.204 g per year when maternal age was less than 24 years old (95%CI: 14.323, 18.086), and increased 12.051g per year when maternal age ranged from 24 to 34 years old (95%CI: 11.609, 12.493), then decreased 0.824g per year (95% CI: -3.112, 1.464). The risk of low birth weight decreased with the increase of maternal age until 36 years old (OR= 0.917, 95%CI: 0.903, 0.932 when maternal age was younger than 27 years old; OR= 0.965, 95%CI: 0.955, 0.976 when maternal age ranged from 27 to 36 years old), then increased when maternal age was older than 36 years old (OR=1.133, 95%CI: 1.026, 1.250). The risk of macrosomia increased with the increase of maternal age (OR=1.102, 95%CI: 1.075, 1.129 when maternal age was younger than 24 years old; OR=1.065, 95%CI: 1.060, 1.071 when maternal age ranged from 24 to 33 years old; OR=1.029, 95%CI: 1.012, 1.046 when maternal age was older than 33 years old).Conclusions: For women of childbearing age (20-40 years old), the threshold of maternal age on low birth weight was 36 years old, and the risk of macrosomia increased with the increase of maternal age.
Homocysteine promotes migration of adventitial fibroblasts via Angiotensin II type 1 receptor activation to aggravate atherosclerosis
Authors: Zhu Zhibo , Hao Xiangyu , Li Tianxiang , Guo Jianqiang 
Published: October 2020

Abstract
Background: Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis. However, the mechanisms of HHcy-induced arteriosclerosis are largely unknown. Objective: To clarify the effect of Hcy on adventitial fibroblasts (AFs) and its relation with angiotensin II type 1 receptor (AT1R). Method: The apolipoprotein E gene-deficient mice (Apoe−/−) were used as the murine model for atherosclerosis. HHcy was induced and treated by feeding them 1.5% methionine and telmisartan (gavage 10 mg/kg/d) for 12 weeks, respectively. The AFs and HEK293A cells transfected with the AT1R plasmid were used to investigate the interaction between Hcy and AT1R. All data were expressed as mean ± SEM. The data were analyzed by one-way ANOVA or repeated measurement ANOVA. Results: HHcy aggravated the plaque area of the aortic root and increased the expression of IL-6, MCP-1, and the macrophage marker Mac3 in the plaque and adventitia of the aorta, whereas telmisartan improved this effect. Hyperhomocysteinemia induced the occurrence of the AFs marker protein ER-TR7 in the plaque and the entire layer of the aorta, whereas telmisartan also improved this effect, indicating that hyperhomocysteinemia induced AFs migration and that AT1R mediated this process. Hcy increased the production of AFs H 2 O 2 , ROS, and IL-6 of AFs, indicating that Hcy activated the oxidative stress and inflammatory reactions, which may induce cell migration. The subsequent scratch and transwell experiments confirmed that Hcy induced the AFs migration and that telmisartan inhibited this effect. Hcy increased the expression of AFs AT1R and the phosphorylation levels of PKC and ERK1/2 in the AF and HEK293A cells transfected with the AT1R plasmid, whereas telmisartan inhibited this effect, indicating that Hcy activated AT1R intracellular signaling pathway. Conclusion: Hcy promoted adventitial inflammation, induced AFs migration, and aggravated atherosclerosis by activating AT1R.
Association of immunological features with COVID-19 severity: a systematic review and meta-analysis
Authors: Zhang Zhicheng , Ai Guo , Chen Liping , Liu Shunfang , Gong Chen , Zhu Xiaodong , Zhang Chunli , Qin Hua , Hu Junhui , Huang Jinjin 
Published: October 2020

Abstract
Background: We aim to explore the association of immunological features with COVID-19 severity.Methods: We conducted a meta-analysis to estimate mean difference (MD) of immune cells and cytokines levels with COVID-19 severity in PubMed, Web of Science, Scopus, the Cochrane Library and the grey literature.Results: A total of 21 studies with 2033 COVID-19 patients were included. Compared with mild cases, severe cases showed significantly lower levels of some immune cells, CD3+ T cell (×106, MD, -413.87; 95%CI, -611.39 to -216.34), CD4+ T cell (×106, MD, -203.56; 95%CI, -277.94 to -129.18), CD8+ T cell (×106, MD, -128.88; 95%CI, -163.97 to -93.79), B cell (×106/L; MD, -23.87; 95%CI, -43.97 to -3.78) and NK cell (×106/L; MD, -57.12; 95%CI, -81.18 to -33.06), and significantly higher levels of some cytokines, TNF-α (pg/ml; MD, 0.34; 95%CI, 0.09 to 0.59), IL-5 (pg/ml; MD, 14.2; 95%CI, 3.99 to 24.4), IL-6 (pg/ml; MD, 13.07; 95%CI, 9.80 to 16.35), and IL-10 (pg/ml; MD, 2.04; 95%CI, 1.32 to 2.75), and significantly higher levels of some chemokines, MCP-1 (SMD, 3.41; 95%CI, 2.42 to 4.40), IP-10 (SMD, 2.82; 95%CI, 1.20 to 4.45) and eotaxin (SMD, 1.55; 95%CI, 0.05 to 3.05). However, no significant differences were found in other indicators, Treg cell (×106, MD, -0.13; 95%CI, -1.40 to 1.14), CD4+/CD8+ ratio (MD, 0.26; 95%CI, -0.02 to 0.55), IFN-γ (pg/ml; MD, 0.26; 95%CI, -0.05 to 0.56), IL-2 (pg/ml; MD, 0.05; 95%CI, -0.49 to 0.60), IL-4 (pg/ml; MD, -0.03; 95%CI, -0.68 to 0.62), GM-CSF (SMD, 0.44; 95%CI, -0.46 to 1.35), and RANTES (SMD, 0.94; 95%CI, -2.88 to 4.75).Conclusion: Our meta-analysis revealed significant lower levels of immune cells (CD3+ T, CD4+ T, CD8+ T, B and NK cells), significant higher levels of cytokines (TNF-α, IL-5, IL-6 and IL-10) and significant higher levels of chemokines (MCP-1, IP-10 and eotaxin) in severe cases compared with mild cases of COVID-19. Measurement of immunological features could help to assess disease severity for effective triage of COVID-19 patients.
Non-Templated Oligo-Adenylation of Small RNAs in the Parasite Entamoeba: Potential Roles for Small RNA Control in Single Celled Eukaryotic Pathogen
Authors: Zhang Hanbang , Ehrenkaufer Gretchen M , Hall Neil , Singh Upinder 
Published: October 2020

Abstract
Background: The RNA interference (RNAi) pathway is a gene regulation mechanism that uitilizes small RNA (sRNA) and Argonaute (Ago) proteins to silence target genes. Our previous work identified a functional RNAi pathway in the protozoan parasite Entamoeba histolytica, including abundant 27nt antisense sRNA populations derived from the secondary RNAi pathway which associate with EhAgo2-2 protein. However, there is lack of understanding about sRNAs that are bound to two other EhAgos (EhAgo2-1 and 2-3), and the mechanism of sRNA regulation itself is unclear in this parasite. Results: In the present study, we sequenced sRNA libraries from both total RNAs and EhAgo bound RNAs. We identified a new population of 31nt sRNAs that results from the addition of a non-templated 3-4 adenosine nucleotides at the 3´-end of the 27nt sRNA populations, indicating a non-templated RNA-tailing event in the parasite. We found that both sRNA populations (27nt and 31nt) are unchanged during the development of E. invadens. However, we detected an alteration in their relative abundance for the targeted gene in parasites transfected with a trigger-gene silencing construct, indicating that non-templated RNA-tailing is likely a pathway for sRNA turnover when the targeted gene is unable to be silenced in this parasite. In sequencing the sRNAs associating with the three EhAgo proteins, we observed that despite distinct cellular localization, all three EhAgo sRNA libraries contain 27nt sRNAs with 5´-polyphosphate (5´-polyP) structure and a largely overlapping sRNA repertoire, mainly targeting retrotransposons and a subset of ~226 genes that are endogenously silenced. Furthermore, our data show that 31nt sRNA populations paritally associate with wildtype EhAgo2-2 but not with its mutant protein (EhAgo2-2 C-terminal deletion), indicating an intact RISC is essential for the sRNA modification process.Conclusion: High-throughput sequencing of sRNA in Entamoeba has identified a new population of sRNA with non-templated adenylation modification, which is the first such observation amongst single cell protozoan parasites. Our sRNA sequencing libraries provide the first comprehensive sRNA dataset for all three Entamoeba Ago proteins, which can serve as a useful database for the amoeba community.
Postural Control Strategy after Incomplete Spinal Cord Injury: Effect of Sensory Inputs on Trunk-Leg Movement Coordination
Authors: Noamani Alireza , Lemay Jean-François , Musselman Kristin E. , Rouhani Hossein 
Published: October 2020

Abstract
Background: Postural control is affected after incomplete spinal cord injury (iSCI) due to sensory and motor impairments. Any alteration in the availability of sensory information can challenge postural stability in this population and may lead to a variety of adaptive movement coordination patterns. Hence, identifying the underlying impairments and changes to movement coordination patterns is necessary for effective rehabilitation post-iSCI. This study aims to compare the postural control strategy between iSCI and able-bodied populations by quantifying the trunk-leg movement coordination under conditions that affects sensory information.Methods: 13 individuals with iSCI and 14 aged-matched able-bodied individuals performed quiet standing on hard and foam surfaces with eyes open and closed. We used mean Magnitude-Squared Coherence between trunk-leg accelerations measured by accelerometers placed over the sacrum and tibia. Results: We observed a similar ankle strategy at lower frequencies (f≤1.0 Hz) between populations. However, we observed a decreased ability post-iSCI in adapting inter-segment coordination changing from ankle strategy to ankle-hip strategy at higher frequencies (f>1.0 Hz). Moreover, utilizing the ankle-hip strategy at higher frequencies was challenged when somatosensory input was distorted, whereas depriving visual information did not affect balance strategy.Conclusion: Trunk-leg movement coordination assessment showed sensitivity, discriminatory ability, and excellent test-retest reliability to identify changes in balance control strategy post-iSCI and due to altered sensory inputs. Trunk-leg movement coordination assessment using wearable sensors can be used for objective outcome evaluation of rehabilitative interventions on postural control post-iSCI.