bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structuration du sujet et liens de filiation contemporains
Authors: Berger Frédérique F. 
Published: August 2020

Pour approcher certaines transformations actuelles de la famille et leurs incidences sur la structuration subjective et les liens de filiations contemporains, nous interrogerons à la fois des éléments concernant la famille et la dette filiale mais aussi le droit et la filiation contemporaine ainsi que les modalités actuelles de la PMA et leurs effets. Le discours social individualiste et égalitaire invite à une jouissance de tout pour tous favorisant peut-être la naissance d’une nouvelle économie psychique et de nouveaux désarrois subjectifs. Dans ce contexte d’une toute jouissance quelle est l’incidence des nouvelles lois sur la famille et plus particulièrement sur la filiation et le lien social contemporain ? Quels sont les enjeux et les effets de la procréation et de la PMA sur la transmission des liens de filiation, la dette intergénérationnelle et transgénérationnelle ? La place de l’enfant et le désir d’enfant dans notre société est au cœur de la pratique de nombreux cliniciens engagés dans le travail auprès des enfants et des familles, cet article se propose d’ouvrir quelques pistes de réflexion.
Crime et fonction de la prison : privation de liberté, corps et sens de la peine
Authors: Tiscini Giorgia , Lamote Thierry 
Published: August 2020

Objectif : l’objectif de cet article est de montrer que la peine d’emprisonnement, sans un travail sur le sens de celle-ci, engendre un accroissement de violence, impulsivité, colère, angoisse et haine, affects dont nous montrerons les liens avec la notion lacanienne de jouissance . Méthode : analyse des textes fondateurs de la conception moderne de la prison articulée à la méthodologie de l’entretien clinique pratiqué dans le cadre du travail psychologique/psychothérapeutique mené durant six ans, dans les prisons françaises, avec les personnes détenues. Résultats : les résultats, tirés des entrevues et des observations conjointes à une révision historique de la prison et de sa place dans une société républicaine et démocratique, montrent que la peine privative de liberté doit s’accompagner d’un travail autour du crime, envisagé comme un événement traumatique pour son auteur. Conclusions : les deux objectifs de la peine de prison – amendement du criminel et réinsertion sociale – ne pourront être atteints sans un accompagnement des personnes détenues, de leur vie, des raisons de leurs actes, et leur capacité d’adaptation à la détention. Faute de ce travail, le corps prendra le dessus s’exprimant par des actes ou des affects extrêmes dirigées contre lui-même ou les autres.
Contribution à la question du temps chez les sujets dits états limites
Authors: Magnier Wilfrid , Germain Patrick , Caron Rosa 
Published: August 2020

Le but de cet article est d’examiner ce que Vincent Estellon appelle le temps zapping des sujets dits limites à la lumière du temps logique et de la logique modale proposés par Lacan. La clinique des sujets limites amène les auteurs de cet article à entendre le « zapping » comme ratage du moment de conclure, soit la catégorie du possible définie par Lacan comme « ça cesse de s’écrire ». À partir de cette lecture modale du temps, ils proposent l’hypothèse d’une angoisse de perdre l’adresse de l’autre.
Post-vérité, complots, fake news : d’une fictionnalisation de la vérité au mythe de la facticité
Authors: Troubé Sarah , Guénoun Tamara 
Published: August 2020

L’article interroge le phénomène actuel récemment désigné sous le terme de post-vérité, comme symptomatique des mutations du rapport au mythe et à la fiction au sein de la postmodernité. La propagation, via les réseaux sociaux notamment, des faits alternatifs, fake news et théories du complot questionne en particulier le statut de la réalité de l’espace virtuel et numérique, propice à faire surgir un mythe de la transparence absolue qui, psychiquement inassimilable comme tel, se renverse en mythe de la facticité dans lequel toute réalité est dénoncée comme truquée. À partir du déplacement opéré par l’approche psychanalytique de la notion de vérité – qui invite à la concevoir comme construction et comme structure de fiction –, nous proposons d’entendre les constructions de la post-vérité comme la marque d’une vérité dé-fictionnalisée et non médiatisée, signant un échec de la transitionnalité et propice à susciter des mouvements archaïques d’intrusion et d’identification projective.
Les perspectives énergétiques mondiales, horizon 2040
Authors: Cozzi Laura 
Published: August 2020

En mars dernier, Futuribles a lancé une nouvelle série consacrée au climat et à la transition écologique : des enjeux de long terme essentiels qui nous semblaient peu ou mal pris en compte par les gouvernements. Juste après s’est propagée la pandémie de Covid-19, assortie d’une crise économique internationale majeure qui va pousser la plupart des pays du monde à mettre en place des plans de relance pour y faire face. La situation dramatique actuelle est sans aucun doute aussi une occasion de combiner les deux défis écologique et économique, et pour ce faire, disposer d’une vision à long terme des perspectives énergétiques mondiales est capital. Laura Cozzi, en charge de l’élaboration de ces perspectives au sein de l’AIE, présente ici les scénarios envisageables à l’horizon 2040, en tenant compte du grand bouleversement induit par la crise du Covid-19 (crise économique, interruption des transports, baisse de la consommation…) et des objectifs climatiques internationaux. Après un rappel du choc que constitue cette crise pour le système énergétique mondial, elle souligne l’urgence de régler les problèmes anciens qui pèsent lourdement dans les émissions de gaz à effet de serre (en particulier les centrales à charbon). Elle montre ensuite combien l’électricité est stratégique aujourd’hui, et donc combien il est important d’accroître le poids des sources renouvelables dans la production électrique et d’investir dans les technologies de stockage (batteries). Elle souligne ainsi le rôle clef des technologies énergétiques pour, à terme, décarboner nos économies et les rendre plus résilientes, invitant les États à investir substantiellement dans ce domaine. S.D.
Les amis qui n’apparaissent pas sur les photos
Authors: Adamo Simonetta M. G. 
Published: August 2020

Je décris dans cet article le traitement psychanalytique d’un garçon de 14 ans qui souffrait d’une forme moyennement grave du syndrome d’Asperger. Cet adolescent avait quantité de compagnons imaginaires qui le protégeaient contre ses angoisses catastrophiques d’anéantissement, mais qui en même temps interféraient avec sa capacité d’établir des relations significatives avec des êtres humains. Tandis que sa relation avec la thérapeute regagnait peu à peu la vitalité et l’importance qu’il avait originellement investies dans son monde parallèle fantasmatique, les compagnons imaginaires s’évanouirent. Son imagination devient alors plus étroitement liée à sa réalité intérieure et aux processus créatifs. Une revue de la littérature psychanalytique sur les compagnons imaginaires est proposée et il est suggéré que le concept d’un mécanisme d’autoprotection peut s’appliquer de manière utile pour comprendre les fonctions remplies par ce fantasme pour le patient. On envisage également l’aspect addictif de ces constructions et il est suggéré qu’elles apportent une « alliance douteuse » contre les douleurs de la dépendance.
L’Europe à géométrie variable
Authors: Faure Samuel B. H. , Lebrou Vincent 
Published: August 2020

Depuis le début du XXI e siècle, les études européennes ont développé leur intérêt pour l’analyse de « l’Europe à géométrie variable ». Cette introduction propose un dialogue critique avec les théories classiques de l’intégration européenne qui conceptualisent la différenciation « horizontale » (variations territoriales) et la différenciation « verticale » (variations dans la centralisation du pouvoir d’une politique publique à une autre). Une troisième logique de différenciation dite « transversale » est proposée pour saisir les groupes professionnels qui travaillent à construire une Europe à géométrie variable pensée comme un fait social.
Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8+ T Cell Development
Authors: Amani Mohammad Farhad , Rolig Annah S. , Redmond William L. 
Published: August 2020

Abstract
CD8+ T cells are critical mediators of adaptive immunity, and enhancing their function can promote robust responses against invading pathogens and neoplastic cells. In addition to TCR stimulation, the provision of costimulation through ligation of TNFR family members, such as OX40 (CD134), provides essential signals driving T cell differentiation, survival, and memory in part through enhanced IL-2/IL-2R signaling. Interestingly, TCR stimulation in the presence of IL-2 upregulates intracellular expression of the β-galactoside binding protein, Galectin-3 (Gal-3). Gal-3 has been shown to regulate Th1/Th2 polarization of CD4+ T cells; however, the extent to which Gal-3 regulates the OX40/IL-2 signaling axis and CD8+ T cell proliferation, effector function, and/or survival is unknown. In this study, we demonstrate that murine Gal-3–deficient CD8+ T cells exhibited no defects in early (36 h) activation or proliferation following TCR stimulation. In contrast, Gal-3−/− CD8+ T cells exhibited decreased survival and a reduced capacity to develop into memory cells following stimulation with cognate Ag plus agonist anti-OX40 mAb or IL-2 in vivo. Decreased survival of Gal-3−/− T cells was associated with increased apoptosis and occurred in a cell-intrinsic manner. Together, these data implicate intracellular Gal-3 as a critical mediator of OX40-mediated CD8+ T cell survival and memory formation following Ag exposure.
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells
Authors: Oba Takaaki , Hoki Toshifumi , Yamauchi Takayoshi , Keler Tibor , Marsh Henry C. , Cao Xuefang , Ito Fumito 
Published: August 2020

Abstract
In vivo expansion of adoptively transferred CD8+ T cells is a critical determinant of successful adoptive T cell therapy. Emerging evidence indicates Batf3-dependent conventional type 1 dendritic cells (cDC1s) rarely found within the tumor myeloid compartment are crucial for effector T cell recruitment to the tumor microenvironment. However, the role of cDC1s in expansion of tumor-specific CD8+ T cells remains unclear. In this article, we addressed the role of cDC1s and their costimulatory molecules, CD40, CD70, and CD80/CD86, in expansion and antitumor efficacy of adoptively transferred in vitro–primed CD8+ T cells recognizing nonmutated tumor-associated self-antigens. We found that TLR/CD40–mediated expansion and antitumor efficacy of adoptively transferred tumor-specific CD8+ T cells were abrogated in Batf3−/− mice. Further mechanistic studies using mixed bone marrow chimeric mice identified that CD40 and CD70 but not CD80/CD86 signaling in cDC1s played a critical role in expansion and antitumor efficacy of adoptively transferred CD8+ T cells. Moreover, induction and activation of cDC1s by administration of FMS-like tyrosine kinase 3 ligand (Flt3L) and TLR/CD40 agonists augmented expansion of adoptively transferred CD8+ T cells, delayed tumor growth, and improved survival. These findings reveal a key role for CD40 and CD70 signaling in cDC1s and have major implications for the design of new vaccination strategies with adoptive T cell therapy.
Quality evaluation of sweetpotato-based complementary food
Authors: Olatunde S.J. , Oyewole O.D. , Abioye V.F. , Babarinde G.O. , Adetola R.O. 
Published: August 2020

Complementary Food (CF) was developed using locally available food raw materials (millet, soybean and sweetpotato) to tackle infant malnutrition especially in rural areas. Four different samples of CF were formulated using different ratios of millet flour (MF), sweet potato flour (SPF), soybean flour (SBF); A (55% MF, 30% SPF and 15%SBF), B (50% MF, 30% SPF and 20%SBF), C (45% MF, 30% SPF and 25%SBF), and D (40% MF, 30% SPF and 30% SBF). Commercial complementary food (Nutribom) was used as control sample. The proximate and functional properties of the formulated CF were determined. The following range of values were obtained for all the complementary samples, moisture (2.98-9.05%), protein (5.06-13.19%), fat (2.50-8.71%), fibre (0.13-2.19%), ash (1.26-2.31%) and carbohydrate (55.6-57.6%). The protein, fat and fibre contents of the complementary food increased while moisture, ash and carbohydrate contents reduced with an increase in the level of SBF. The water absorption capacity, swelling power, and bulk density of the complimentary food samples ranged between 28.00 and 43.67 ml/g; 2.86 and5.22 (g/g) and 0.69and 0.81 g/ml, respectively. The functional properties of the complementary food increased when compared with the control. The complementary food blends that could be regarded as appropriate formulation based on the exhibited quality attributes evaluated was sample B which contained 50, 30 and 20% of MF, SPF and SBF, respectively. This product can serve as an alternative to commercial weaning food to prevent protein-energy malnutrition, which may help in the growth and development of children among the poor populace.
Keywords: Complementary foods, functional properties, proximate properties and minerals contents
Bacteriological profile of selected fish species and water sample from Otuocha River Anambra State
Authors: Amuneke K.E. , Igbodiegwu G.C. , Okeke P.A. , Adibe A.C. 
Published: August 2020

Attempt to ensure fish food security is a continuous process and food safety is a global concern for consumers and food industry. Fish is an important source of healthy and cheap source of animal protein that among its numerous benefit fish is widely acceptable, across socio-economic, age and religious barrier. However, supply of contaminated free fish is desirable to ensure safe consumption and a healthy consumer public`. The objective of the study is to provide baseline information on the microbial quality of Otuocha river, hence establish the microbial quality of fish caught in Otuocha river. Five fish species (Aruis gigas, Bagrus bayad, Schilbe mystus, Chrysichthys nigroditatus and Protopterus annectens) and water sample were taken from Otuocha fish landing site and river respectively and transported to laboratory. The fish samples were cleaned with sterile distilled water and 1 g of skin, gills, intestine cut aseptically and labelled along with water sample before microbial analysis following standard method. The result obtained in water and fish samples showed high microbial load in Otuocha river and was attributed to anthropogenic sources. Nine different bacteria were isolated in fish samples while seven were isolated in water sample. The study concluded that Otuocha river has high microbial load, hence recommend that fish from Otuocha river should be properly cooked/smoked before consumption and sanitary standard of Otuocha river and its environs be improved while public enlightenment on waste disposal be undertaken.
Key words: Microbial load, fish, water, Otuocha River
Different Approaches to Enantiosemy in English
Authors: Kajberuny Hasmik , Hakobyan Tamara 
Published: August 2020

Our interest in this article is to investigate different approaches to enantiosemy in English. In the coverage of a variety of viewpoints introduced in the present article, reference is made to well-established traditional and most recent perspectives and approaches provided by both European and Russian scholars with the view of elucidating different principles of classification.
The data for the analysis are extracted from different dictionaries and British National Corpus in order to find distinct motivated meanings between opposite senses in the semantic structure of enantiosemic words. The analysis of the data enables us to reveal some regularities of antonymic relations which make it possible to regard them as special cases of polysemy in English.
For this reason we consider it crucial to disclose integral and differentiating semes, as well as different potential semes, which give rise to different associations.
(How) Can Recent Cognitive Studies Contribute to Literary Interpretation?
Authors: Locatelli Angela 
Published: August 2020

This essay wishes to engage with the crucial issue of the interpretation of literary texts from the specific perspective of the rise of Cognitive Sciences in the past two or three decades.
One of the stimulating, but also controversial elements of Cognitive Literary Studies is the variety of denominations of the field itself. Different labels have been adopted to define it, including: “Cognitive Poetics”, “Cognitive Semiotics”, “Cognitive Stylistics”, “Cognitive Literary Studies”, “Cognitive Criticism”, and “Cognitive Literary Science”.
A crucial problem that has variously been dealt with but that still remains open to discussion (and has sometimes promoted a questioning of the usefulness of the neurosciences in the interpretation of literary works), is the problem of the affordances of a cognitive approach to the specificity of literary artifacts. This contribution will therefore address and investigate this timely topic and illustrate aspects of the dynamics of literary interpretation that the cognitive sciences have recently productively developed.
In particular, it will focus on the following elements: various perspectives in “the neurohumanities”, “literariness and the brain”, “the respective contribution of the cognitive sciences and of literature to the knowledge of the human mind”.
MOTIVASI BELAJAR MEMPENGARUHI TERHADAP HASIL BELAJAR SISWA KELAS V DI SEKOLAH DASAR
Authors: Simanjuntak Harlen 
Published: August 2020

ABSTRACT
The purpose of this study was to determine how much motivation to learn affects the learning outcomes of fifth grade students in elementary schools 064021 Medan City. The method used is a quantitative correlational method with data collection techniques by means of library research and field research through interviews, observations and documentation. With the results of the calculation of the correlation number of variable X (learning motivation) to the variable Y (learning outcomes) of 0.965. This means that the effect of learning motivation on student learning outcomes in grade V SDN 064021 Medan Helvetia Medan city is very high.
Keywords: learning motivation, influencing, learning outcomes, students
IMPLEMENTASI MANAJEMEN KESISWAAN UNTUK MENINGKATKAN KUALITAS AKADEMIK PESERTA DIDIK DI SMP IT AT-THOHIRIAH
Authors: Rahmatullah M Najmudin , Tholkhah Imam , Primarni Amie 
Published: August 2020

ABSTRACT
Management is a process of activities that are planned and carried out intentionally and continuously to all students in the relevant educational institutions in order to be able to participate in the learning and teaching process effectively and efficiently. Learning achievement is the level of humanity students have in accepting, rejecting and assessing the information obtained in the teaching and learning process. A person's learning achievement is in accordance with the level of success of something in learning subject matter which is expressed in the form of grades or report cards for each field of study after experiencing the teaching and learning process. This study aims to determine the extent of implementation, acceptance, student management, efforts made, as well as the implications of the application of student management in At-Thiriiriah Junior High School in improving the quality of students. This study uses a qualitative approach using a type of case study research by taking a background in At-Thiriahah Junior High School, Gunung Bunder I, Pamijahan, Bogor. Data collection is done by interview, observation and documentation. Data analysis uses descriptive analysis method. Based on the process of data collection and data analysis, researchers can conclude several things including: (1) The application of student management that takes place at At-Thiriahah IT Junior High is classified as good, where the concept of student management starts from the planning and implementation of new students, monitoring or control and evaluation can be applied by all at IT Thohiriah Junior High School. (2) In an effort made by schools related to student management to improve the quality of students in At-Thiriahah Junior High School, among others: improving discipline including a). At-Thiriahah Junior High School students arrive at 07.00 WIB, b) Wearing Uniforms. (3) As for the implications of the implementation of student management to improve the quality of students in At-Thiriah Gunung Bunder I Junior High School, seen from the academic achievement in the form of UN scores that have increased, non-academic achievements achieved by At-Thiriahah IT Middle School students have also increased, and graduates of At-Thiriiriah IT Middle School were accepted into public and private schools.
Keywords: Student Management, Academic Quality of Students
Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer
Authors: Yi-Wen Wang , Long-Long Li , Ming Lu , Hao Li , Kong-Wang Hu 
Published: August 2020

IntroductionCirculating tumor cells (CTCs) have the characteristics of cancer stem cells and play an important role in the recurrence and metastasis of tumors. CD44 is a surface marker molecule for gastric cancer stem cells (GCSCs) and can be used to identify and isolate GCSCs. Here, we investigated the effect of CD44 protein expression, circulating tumor cells, and CD44-positive CTCs on the prognosis of gastric cancer (GC).Material and methodsBlood samples from 58 GC patients being treated at the First Affiliated Hospital of Anhui Medical University from August 2015 to October 2016 were obtained before surgery. The cancer tissues from 58 GC patients after surgery and the same amount of adjacent normal tissues 5 cm away from the center of the cancer tissues were collected as controls. Immunohistochemistry was used to detect CD44 expression in cancer tissues and adjacent normal tissues. Immunomagnetically negative enrichment combined with im-FISH was used to detect CTCs and CD44-positive CTCs in gastric cancer patients.ResultsCirculating tumor cells were detected in 44 of 58 patients, and CD44 protein was positive in 34 cases of GC. The presence of CTCs and CD44 is significantly associated with depth of tumor infiltration, lymph node metastasis, TNM stage, and recurrence (p < 0.01). Twenty-nine of 44 CTC-positive patients had CD44-positive CTCs. The patients with CD44-positive CTCs were more likely to develop recurrence than patients with CD44-negative CTCs (p < 0.01). Furthermore, 28 of 29 patients with CD44-positive CTCs developed recurrent disease, and the mean time to recurrence was shorter than that in patients with CD44-negative CTCs (16.030 ±5.268 and 21.800 ±4.601 months; p < 0.01). The Cox proportional hazards model indicated that the presence of CD44-positive CTCs and TNM stage were independent predictors of recurrence for GC (p = 0.044 and 0.035).ConclusionsThe detection of stem cell characteristics of GC CTCs can provide more prognostic information than simply detecting GC CTCs and GC CD44 expression.