bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas
Authors: Valentine-King Marissa A. , Cisneros Katherine , James Margaret O. , Huigens Robert W. , Brown Mary B. 
Published: April 2020

AbstractBackgroundMycoplasmas primarily cause respiratory or urogenital tract infections impacting avian, bovine, canine, caprine, murine, and reptilian hosts. In animal husbandry, mycoplasmas cause reduced feed-conversion, decreased egg production, arthritis, hypogalactia or agalactia, increased condemnations, culling, and mortality in some cases. Antibiotics reduce transmission and mitigate clinical signs; however, concerning levels of antibiotic resistance inMycoplasma gallisepticumandM. capricolumisolates exist. To address these issues, we evaluated the minimum inhibitory concentrations (MICs) of halogenated phenazine and quinoline compounds, anN-arylated NH125 analogue, and triclosan against six representative veterinary mycoplasmas via microbroth or agar dilution methods. Thereafter, we evaluated the minimum bactericidal concentration (MBC) of efficacious drugs.ResultsWe identified several compounds with MICs ≤25 μM againstM. pulmonis(n = 5),M. capricolum(n = 4),M. gallisepticum(n = 3),M. alligatoris(n = 3),M. agassizii(n = 2), andM. canis(n = 1). AnN-arylated NH125 analogue, compound 21, served as the most efficacious, having a MIC ≤25 μM against all mycoplasmas tested, followed by two quinolines, nitroxoline (compound 12) and compound 20, which were effective against four and three mycoplasma type strains, respectively. Nitroxoline exhibited bactericidal activity among all susceptible mycoplasmas, and compound 21 exhibited bactericidal activity when the MBC was able to be determined.ConclusionsThese findings highlight a number of promising agents from novel drug classes with potential applications to treat veterinary mycoplasma infections and present the opportunity to evaluate preliminary pharmacokinetic indices usingM. pulmonisin rodents as an animal model of human infection.
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose
Authors: Laurent Danny , Semple Fiona , Starkey Lewis Philip J. , Rose Elaine , Black Holly A. , Coe Jennifer , Forbes Stuart J. , Arends Mark J. , Dear James W. , Aitman Timothy J. 
Published: April 2020

Abstract
Background
Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-specific methylation and nucleosomal profiling.

Methods
We performed the first direct, absolute measurement of the tissue origins of cfDNA, using tissue-specific knockout mouse strains, in both healthy mice and following paracetamol (APAP) overdose. We then investigated the utility of total cfDNA and the percentage of liver-specific cfDNA as clinical biomarkers in patients presenting with APAP overdose.

Results
Analysis of cfDNA from healthy tissue-specific knockout mice showed that cfDNA originates predominantly from white and red blood cell lineages, with minor contribution from hepatocytes, and no detectable contribution from skeletal and cardiac muscle. Following APAP overdose in mice, total plasma cfDNA and the percentage fraction originating from hepatocytes increased by ~ 100 and ~ 19-fold respectively. Total cfDNA increased by an average of more than 236-fold in clinical samples from APAP overdose patients with biochemical evidence of liver injury, and 18-fold in patients without biochemically apparent liver injury. Measurement of liver-specific cfDNA, using droplet digital PCR and methylation analysis, revealed that the contribution of liver to cfDNA was increased by an average of 175-fold in APAP overdose patients with biochemically apparent liver injury compared to healthy subjects, but was not increased in overdose patients with normal liver function tests.

Conclusions
We present a novel method for measurement of the tissue origins of cfDNA in healthy and disease states and demonstrate the potential of cfDNA as a clinical biomarker in APAP overdose.
The preceding root system drives the composition and function of the rhizosphere microbiome
Authors: Zhou Yi , Coventry David R. , Gupta Vadakattu V. S. R. , Fuentes David , Merchant Andrew , Kaiser Brent N. , Li Jishun , Wei Yanli , Liu Huan , Wang Yayu , Gan Shuheng , Denton Matthew D. 
Published: April 2020

Abstract
Background
The soil environment is responsible for sustaining most terrestrial plant life, yet we know surprisingly little about the important functions carried out by diverse microbial communities in soil. Soil microbes that inhabit the channels of decaying root systems, the detritusphere, are likely to be essential for plant growth and health, as these channels are the preferred locations of new root growth. Understanding the microbial metagenome of the detritusphere, and how it responds to agricultural management such as crop rotations and soil tillage, is vital for improving global food production.

Results
This study establishes an in-depth soil microbial gene catalogue based on the living-decaying rhizosphere niches in a cropping soil. The detritusphere microbiome regulates the composition and function of the rhizosphere microbiome to a greater extent than plant type: rhizosphere microbiomes of wheat and chickpea were homogenous (65–87% similarity) in the presence of decaying root (DR) systems but were heterogeneous (3–24% similarity) where DR was disrupted by tillage. When the microbiomes of the rhizosphere and the detritusphere interact in the presence of DR, there is significant degradation of plant root exudates by the rhizosphere microbiome, and genes associated with membrane transporters, carbohydrate and amino acid metabolism are enriched.

Conclusions
The study describes the diversity and functional capacity of a high-quality soil microbial metagenome. The results demonstrate the contribution of the detritusphere microbiome in determining the metagenome of developing root systems. Modifications in root microbial function through soil management can ultimately govern plant health, productivity and food security.
Mat Pilates is as effective as aquatic aerobic exercise in treating women with fibromyalgia: a clinical, randomized and blind trial
Authors: de Medeiros Suzy Araújo , de Almeida Silva Hugo Jário , do Nascimento Rayssa Maria , da Silva Maia Jaely Beatriz , de Almeida Lins Caio Alano , de Souza Marcelo Cardoso 
Published: April 2020

Abstract
Background
The mat Pilates method is the therapeutic modalities which can be used in fibromyalgia treatment. Although there are no well-designed studies that prove the effectiveness of the mat Pilates method in this population. The objective was to evaluate the effectiveness of the mat Pilates method for improving symptoms in women with fibromyalgia.

Methods
A single blind randomized controlled trial in which 42 women with fibromyalgia were randomized into two groups: mat Pilates and aquatic aerobic exercise. The exercises were performed twice a week for 12 weeks. Two evaluations were performed: one at baseline (T0), and another at 12 weeks after randomization (T12). The primary outcome was pain measured by the Visual Analogue Scale (VAS). Secondary outcomes were function (Fibromyalgia Impact Questionnaire), sleep (Pittsburgh Sleep Quality Index [PSQI]), quality of life (Short Form 36 [SF-36]), fear avoidance (Fear Avoidance Beliefs Questionnaire [FABQ-BR]) and pain catastrophizing (Pain-Related Catastrophizing Thoughts Scale [PRCTS]).

Results
There was improvement in both groups in relation to pain and function (p < 0.05). The aspects related to quality of life and the FABQ questionnaire only showed improvement in the mat Pilates group (p < 0.05). There was improvement in the PSQI and PRCTS variables only in the aquatic aerobic exercise group (p < 0.05), but no differences were observed between the groups for any of the evaluated variables.

Conclusion
Significant improvements were observed in the two groups in relation to the disease symptoms, and no differences were observed between mat Pilates and aquatic aerobic exercise in any of the measured variables.

Trial registration
ClinicalTrials.gov Identifier (NCT03149198), May 11, 2017. Approved by the Ethics Committee of FACISA/UFRN (Number: 2.116.314).
Australian Indigenous model of mental healthcare based on transdiagnostic cognitive–behavioural therapy co-designed with the Indigenous community: protocol for a randomised controlled trial
Authors: Toombs Maree , Nasir Bushra , Kisely Steve , Kondalsamy-Chennakesavan Srinivas , Hides Leanne , Gill Neeraj , Beccaria Gavin , Brennan-Olsen Sharon , Butten Kayley , Nicholson Geoffrey 
Published: April 2020

BackgroundA four- to seven-fold increase in the prevalence of current mood, anxiety, substance use and any mental disorders in Indigenous adults compared with non-Indigenous Australians has been reported. A lifetime prevalence of major depressive disorder was 23.9%. High rates of comorbid mental disorders indicated a transdiagnostic approach to treatment might be most appropriate. The effectiveness of psychological treatment for Indigenous Australians and adjunct Indigenous spiritual and cultural healing has not previously been evaluated in controlled clinical trials.AimsThis project aims to develop, deliver and evaluate the effectiveness of an Indigenous model of mental healthcare (IMMHC). Trial registration: ANZCTR Registration Number: ACTRN12618001746224 and World Health Organization Universal Trial Number: U1111-1222-5849.MethodThe IMMHC will be based on transdiagnostic cognitive–behaviour therapy co-designed with the Indigenous community to ensure it is socially and culturally appropriate for Indigenous Australians. The IMMHC will be evaluated in a randomised controlled trial with 110 Indigenous adults diagnosed with a current diagnosis of depression. The primary outcome will be the severity of depression symptoms as determined by changes in Beck Depression Inventory-II score at 6 months post-intervention. Secondary outcomes include anxiety, substance use disorder and quality of life. Outcomes will be assessed at baseline, 6 months post-intervention and 12 months post-intervention.ResultsThe study design adheres to the Consolidated Standards of Reporting Trials (CONSORT) statement recommendations and CONSORT extensions for pilot trials. We followed the Standard Protocol Items for Randomised Trials statement recommendations in writing the trial protocol.ConclusionsThis study will likely benefit participants, as well as collaborating Aboriginal Medical Services and health organisations. The transdiagnostic IMMHC has the potential to have a substantial impact on health services delivery in the Indigenous health sector.
High-performance concealment of defective pixel clusters in infrared imagers
Authors: Chen Yaohong , Kang Jin U. , Zhang Gaopeng , Cao Jianzhong , Xie Qingsheng , Kwan Chiman 
Published: April 2020

Defective pixel concealment is a necessary procedure in infrared image processing and is widely used. However, current approaches are mainly focused on the concealment of isolated pixels and small defective pixel clusters. Consequently, these approaches cannot meet the requirements when applied to infrared detectors with large defective pixel clusters. In this paper, we present a novel and comprehensive approach to processing the image data acquired from infrared imagers with large and small defective pixel clusters. Our approach consists of preprocessing, coarse concealment, high dynamic range enhancement, and fine concealment by generative adversarial networks. Experiments using mid-wave infrared and long-wave infrared images demonstrated that the proposed approach achieves better results than the best conventional approach, known as transforming image completion, with the peak signal-to-noise ratio and structural similarity metrics improved by 2.7063 dB (16.3%) and 0.1951 dB (34.1%), respectively.
Numerical Calculation Algorithm for the Model of a Reservoir Bank Transformation
Authors: Zhuravleva V.V. , Efremov I.A. , Marusin K.V. 
Published: April 2020

The relevance of the study lies in the fact that the developed numerical algorithm and the complex of simulation of reservoir bank transformation processes will help to understand what period of time will be needed for the retreat of the bank line inland to reach a given distance. The object of research is the Kachugin model that describes the reservoir bank transformation processes. The method is based on large experimental material and is recognized as the most reliable. The authors propose a developed numerical algorithm to modify this method and obtain the predicted profile of the reservoir bank line for a given period. It should be noted that usage of the simulation complex developed by the authors does not require high costs for obtaining data and calculating forecasts while considering a fairly large number of parameters and factors affecting the processes.
The following tasks are solved in the study: the processes and models of the reservoir bank transformation processes are studied; an algorithmic modification of numerical calculations by the Kachugin method is proposed; a software package for simulation is developed; testing and verification of the developed software package is conducted.
The problems of teacher candidates’ and their psychological sympthoms
Authors: Bulut Sefa , Yıldırım Musa 
Published: April 2020

The purpose of this study was to investigate teacher candidates’ problems and psychological symptoms. The study also aimed at examining psychological symptoms in terms of problem area, gender and department variables. Participants consisted of 77 (63%) female and 44(36%) male sophomore students attending faculty of education. The sample composed of 55 (45%) guidance and psychological counseling students, 43 (35%) elementary school teacher students, and 23 (%19) computer and technology education students.
Symptom Check List (SCL-90), demographic form and a short problem screening survey were used in data collection. Data were analaysized with SPSS 22 package program. The results revealed that, teacher candidates’ scores in SCL 90’s subscales changed between 1.56 (obsessive compulsive) and (psychoticism). Additionally, teacher candidates most frequently experienced anxiety about the upcoming KPSS exam and future anxiety. Finally, psychological symptoms did not changed according to the gender, problem area, and departments variables. The findings were disused with in light of current and previous literature.
​Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet
Bu çalışmanın amacı öğretmen adaylarının problem alanlarını tespit etmek ve öğretmen adaylarının yaşadığı psikolojik belirtilerin problem alanı, cinsiyet ve bölüm değişkenine göre farklılık gösterip göstermediğini incelemektir. Katılımcıların 77(%63.6)’sini kadınlar 44(%36.4)’ünü erkekler oluşturmaktadır. Örneklem grubunun 55(%45.5)’i Rehberlik ve Psikolojik Danışmanlık Bölümünde, 43(%35.5)’ü Sınıf Öğretmenliği Bölümünde ve 23(%19)’ü Bilgisayar ve Öğrenim Teknolojileri Eğitimi Bölümünde öğrenim görmektedir. Araştırmada ölçeme aracı olarak Belirti Tarama Listesi(SCL-90) ve Bilgi Formu kullanılmıştır. Elde edilen veriler SPSS 22.0 paket programında değerlendirilmiştir. Elde edilen bulgular şu şekildedir; öğretmen adaylarının Belirti Tarama Listesinin(SCL-90) alt boyutlarından aldığı puanlar 1,56(OKB) ile .79(Psikotizm) arasında değişmektedir. Bunun yanında öğretmen adaylarının yaşadığı problem alanlarından KPSS kaygısının ve gelecek kaygısının frekansları diğer alanların frekanslarından daha yüksektir. Son olarak psikolojik belirtilerin; cinsiyet, problem alanı ve bölüm değişkenine göre farklılık göstermediği görülmüştür. Elde edilen bulgular alan yazın ışığında tartışılmıştır.
Business Intelligence and Visual Analytics-Based Strategy for disaster risk observatory development
Authors: Sánchez Torres Germán , Villamil Maria del pilar , Moreno Andres , Avendaño Eduard 
Published: April 2020

Resumen
En este artículo, se presenta una estrategia para el desarrollo de observatorios de riesgo de desastres, integrando inteligencia empresarial y análisis visual. El análisis y la contextualización a nivel global se llevan a cabo desde la perspectiva de políticas, herramientas y literatura científica en el contexto de la reducción del riesgo de desastres. La estrategia integra la metodología Kimball para la construcción de proyectos de inteligencia empresarial (BI) y el marco de visualización de Tamara Munzner para fortalecer el proceso de toma de decisiones y hacerlo flexible y más rápido, satisfaciendo las necesidades de los usuarios empresariales. Considerar la gestión del riesgo de desastres como un proceso permite la identificación del punto de partida y los procesos que siguen, lo que resulta en un inicio rápido del ciclo de vida del proyecto. Además, incluir el marco de visualización, junto con la metodología de BI, facilita el desarrollo de herramientas de análisis para resolver los problemas del usuario final.
Sistema probatorio y concurrencia de pruebas: sistema penal acusatorio, prueba ilícita
Authors: Rodr Edwin Alfonso 
Published: April 2020

El presente artículo trata sobre un tema significativo en el ámbito procesal penal colombiano, hoy día ha adquirido un valor probatorio en cuanto a su importancia a nivel judicial. Un conocimiento sólido acerca de la dinámica de las teorías acerca del sistema probatorio en materia, permiten identificar sus diferentes dinámicas al interior del proceso penal. Así mismo, dará cuenta de sus formas en el marco de las estructuras normativas en ámbitos doctrinales y legales. Por otra parte, encontraremos una descripción de la diversidad de acepciones del Derecho Probatorio y las tendencias procesales para su utilización en Colombia. Por ello, en el diálogo discursivo se relacionarán los elementos que lo contextualizan frente a distintas situaciones problema planteadas, por cuanto se hace referencia a metodologías de trabajo jurídico que más adelante se mencionarán los resultados y, por último, se darán a conocer las conclusiones y aportes de manera transversal.

AbstractThis article addresses a significant issue in the Colombian penal procedure field, today has acquired a probative value as to their importance in the courts. A solid about the dynamics of the theories regarding the evidentiary system, to identify their different knowledge dynamics within the criminal process. Also, you will notice forms part of the regulatory structures in doctrinal and legal fields. Moreover, we find a description of the diversity of interpretations of law of evidence and procedural trends for use in Colombia. Therefore, in the discursive dialogue elements that contextualize against different problem situations arising, because reference to methodologies of legal work later, the results will be mentioned is made and, finally, will present the findings will relate and contributions of transverse way.
Las claves de la gestión judicial en chile
Authors: S Jorge Eduardo 
Published: April 2020

El presente artículo de investigación expone ampliamente un estudio sobre los elementos claves que permiten describir las transformaciones realizadas a partir del año 2000 en Chile en materia de gestión judicial, especialmente en el sistema procesal oral, público y adversarial, aunque acciones semejantes se aprecian en la judicatura laboral y de familia; todo ello a partir de los cambios legislativos que modificaron la estructura interna de los tribunales e incorporaron a administradores profesionales, separando a los jueces en tanto tales, de la gerencia de estas organizaciones. Para respaldar los argumentos presentes en este artículo se evidencia con rigor una perspectiva cuantitativa realizada a partir del diseño de agregados construidos por la Corporación Administrativa del Poder Judicial.

AbstractThe present article of investigation, it exposes widely a study on the key elements that allow to describe the transformations realized from the year 2000 in Chile as for judicial management, specially in the procedural oral, public system and adversarial, though similar actions are estimated in the labor judicature and of family, all this from the legislative changes that modified the internal structure of the courts and incorporated professional administrators, separating the judges while you fell, of the management of these organizations. To endorse the present arguments in this article there is demonstrated by rigor a quantitative perspective realized from the attachés’ design constructed by the Administrative Corporation of the Judicial Power.
Alianza bolivariana para los pueblos de nuestra américa- tratado de comercio de los pueblos (alba-tcp) un nuevo modelo de integración regional
Authors: Trejos Rosero Luis Fernando , Pel Melissa Johanna 
Published: April 2020

No son pocos los esfuerzos de integración en el continente con un marcado énfasis regionalista, pero se podría decir que el ALBA-TCP, por su carácter de integración sui generis, se plantea como un instrumento de múltiples dimensiones y una infinidad de intereses socioeconómicos y geopolíticos, que resultan muy interesantes para su comprensión y análisis. Es por esta razón que en el presente trabajo, se pretende realizar una aproximación general a este nuevo mecanismo de integración para la región. En este sentido y en un primer momento, se plantea el marco filosófico que sustenta al ALBA-TCP, para luego mostrar algunos aspectos que la constituyen y que respaldan los compromisos de las diversas naciones que hoy conforman esta iniciativa. Finalmente y a modo de conclusión, se exponen una serie de observaciones para facilitar la reflexión en torno a la información presentada.

AbstractThere are few integration efforts on the continent with a strong regionalist emphasis, but you could say that the ALBA-TCP, by its sui generis character of integration, is presented as a multidimensional instrument and countless socioeconomic and geopolitical interests, which are very interesting for compression and analysis. It is for this reason that this report is intended to give a general approach to this new mechanism of integration for the region. In this sense and at first, the philosophical framework underpinning the ALBA-TCP, and then show some aspects that constitute and support the commitments of the various nations that now make this initiative arises. Finally and in conclusion, a series of observations was set to facilitate reflection on the information presented.
Control constitucional a las subreglas incorporadas en las sentencias de los jueces
Authors: Garc Kristhell Karem 
Published: April 2020

En este artículo se pretende determinar las características del control constitucional aplicado en las subreglas que se incorporan a las sentencias desde la competencia funcional y para ello, se tomó el enfoque metodológico cuantitativo bajo un diseño bibliográfico de tipo documental y nivel histórico, representando las diferentes posiciones surgidas en torno al control constitucional frente a las subreglas establecidas por el precedente emanado de la Corte Constitucional colombiana y la aplicación de un control constitucional difuso que constituye un mecanismo de monitoreo de la legitimidad en el apartamiento de las subreglas aplicadas por parte de los jueces de instancia. Este modelo constituye un aporte teórico metodológico para ejercer el control constitucional difuso.