bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ views of routine quality of life assessment following a diagnosis of early-stage non-small cell lung cancer
Authors: Pompili Cecilia , Boele Florien , Absolom Kate , Holch Patricia , Clayton Beverly , Smyllie Emma , Franks Kevin , Velikova Galina 
Published: June 2020

Abstract

OBJECTIVES
There is an increasing interest in the quality of life (QoL) evaluation following video-assisted thoracoscopic anatomical lung resection or stereotactic ablative body radiotherapy for early-stage non-small-cell lung cancer (NSCLC). A qualitative interview study was conducted to gain insight into the optimal methods of assessing and discussing QoL in clinical practice.

METHODS
A prospective observational longitudinal study of patients with early-stage NSCLC was conducted where repeated QoL measures were administered either online or on paper. A subset of participants was invited for qualitative interviews after the 6-month assessment or at the end of the study. The semi-structured interviews were transcribed verbatim and thematically analysed.

RESULTS
Twenty-three patients were interviewed. Generally, patients were content with recruitment and data collection procedures. Most opted to complete the assessments on paper instead of online; this choice was influenced by the level of technology literacy. Some found the questionnaires too generic to reflect their experiences. Barriers to questionnaire completion were mostly practical, and many acknowledged benefits of QoL assessment including allowing them to express problems and health issues, and following changes over time. Generally, participants would like to discuss QoL results during clinical consultations, but reported this rarely happened.

CONCLUSIONS
Lung cancer patient interviews confirm the acceptability of repeated QoL assessments, but online data capture is limited. Patients highlight the importance of discussing QoL aspects with their clinical team. Future strategies are needed to optimize the routine collection of patient-reported outcomes in clinical practice.
Abbreviated Screening Breast MRI in Women at Higher-than-Average Risk for Breast Cancer with Prior Normal Full Protocol MRI
Authors: Plaza Michael J , Perea Elizabeth , Sanchez-Gonzalez Marcos A 
Published: June 2020

Abstract

Objective
To compare the performance of abbreviated screening breast MRI (ABMR) versus full protocol MRI (FPMR) in women at higher-than-average risk for breast cancer with a prior normal FPMR.

Methods
ABMR was performed on higher-than-average-risk women who had a prior normal FPMR. ABMR protocol consisted of short inversion time inversion recovery imaging, precontrast, and two early postcontrast sequences acquired in under 10 minutes. Retrospective review of ABMR examinations performed from July 2016 to July 2018 was compared with a control group who underwent routine screening with FPMR who had a prior normal FPMR performed from July 2014 to June 2016. Screening outcome metrics were calculated and compared, adjusting for differences in patient demographics.

Results
The study cohort included 481 ABMR examinations, while the control group included 440 FPMR studies. There was no significant difference in the abnormal interpretation rate (AIR) or cancer detection rate (CDR) for the ABMR versus the FPMR group (AIR 6.0% vs 6.8% respectively, odds ratio (OR) 0.91, 95% confidence interval (CI): 0.53–1.5, P = 0.73; CDR 8.3 vs 11 cancers detected per 1000 examinations respectively, OR 0.73, 95% CI: 0.20–2.7, P = 0.64). The PPV2 and PPV3 for the ABMR group was 19% and 21% versus 16% and 16% for the FPMR group, with no statistical difference. Sensitivity was 100% in each group with no interval cancers. There was no difference in specificity between the ABMR and FPMR groups, 93% versus 94%, respectively (P = 0.73).

Conclusion
ABMR may be used to screen higher-than-average-risk women with a prior normal FPMR as outcome metrics are equivalent to FPMR.
Implementation of UN Treaty Body Decisions: A Brief Insight for Practitioners
Authors: Principi Kate Fox 
Published: June 2020

Abstract
The United Nations human rights treaty bodies are independent bodies of experts tasked with monitoring the implementation by states parties of human rights treaties. These bodies monitor the implementation of treaties, inter alia, by making decisions on allegations of individual human rights violations under the individual complaints procedures (these decisions are officially referred to as ‘Views’). The number of complaints to the treaty bodies has increased exponentially since the first complaint was examined by the Human Rights Committee in 1977 and is expected to continue to rise. At the same time, a backlog in cases has increased, as resources have never matched the rise in cases to be considered. In addition, decisions in which the treaty bodies find violations of human rights are not always implemented—that is, states do not necessarily grant the victim of the violation the remedy prescribed by the treaty body examining the case. This current situation is taking place against a global backdrop of increased criticism of human rights: a global pushback against human rights, including from states which have been heretofore human rights supportive. Surely, the response from supporters of human rights should be to reinforce the importance and universality of the treaties as the foundation of human rights norms. This article seeks to demonstrate one way to do so by focusing on implementation of treaty body decisions in individual cases.
Counterparts of Far Eastern Guest Stars: Novae, supernovae, or something else?
Authors: Hoffmann Susanne M , Vogt Nikolaus 
Published: June 2020

ABSTRACTHistorical observations of transients are crucial for studies of their long-term evolution. This paper forms part of a series of papers in which we develop methods for the analysis of ancient data of transient events and their usability in modern science. Prior research on this subject by other authors has focused on looking for historical supernovae and our earlier work focused on cataclysmic binaries as classical novae. In this study we consider planetary nebulae, symbiotic stars, supernova remnants, and pulsars in the search fields of our test sample. We present the possibilities for these object types to flare up visually, give a global overview on their distribution, and discuss the objects in our search fields individually. To summarize our results, we provide a table of the most likely identifications of the historical sightings in our test sample and outline our method in order to apply it to further historical records in future works. Highlights of our results include a re-interpretation of two separate sightings as one supernova observation from May 667 to June 668 CE, the remnant of which could possibly be SNR G160.9+02.6. We also suggest the recurrent nova U Sco as a candidate for the appearance observed between Scorpius and Ophiuchus in 891, which could point towards a long-term variability of eruption amplitudes. In addition, we find that the ‘shiny bright’ sighting in 1431 can be linked to the symbiotic binary KT Eri, which erupted as a naked eye classical nova in 2009.
NLTE spectral analysis of the intermediate helium-rich subdwarf B star CPD−20°1123
Authors: Löbling L 
Published: June 2020

ABSTRACT
Subdwarf B (sdB) stars are core helium-burning stars with stratified atmospheres. Their atmospheres are dominated by hydrogen (H) while the helium (He) and metal abundances are shaped by an interplay of gravitational settling and radiative levitation. However, a small fraction of these show spectra dominated by He i absorption lines. In between these groups of He-deficient and extreme He-rich sdBs, some are found to have intermediate surface He abundances. These objects are proposed to be young ‘normal’ (He-deficient) sdBs for which the dynamical stratification of the atmosphere is still ongoing. We present an analysis of the optical spectrum of such an intermediate He-rich sdB, namely CPD−20°1123, by means of non-local thermodynamic equilibrium (NLTE) stellar atmosphere models. It has a He-to-H number ratio of He/H = 0.13 ± 0.05 and its effective temperature of $\mbox{$T_\mathrm{eff}$} = 25\, 500 \pm 1000 \, \mathrm{K}$ together with a surface gravity of $\log \, (g$ / cm s−2) = 5.3 ± 0.3 places the star close to the high-temperature edge until which it may be justified to use LTE model atmospheres. This work states a test of the Tübingen NLTE Model Atmosphere Package for this temperature regime. We present the first application of revised, elaborated model atoms of low ionization stages of light metals usable with this atmosphere code.
miR-130b regulates gap junctional intercellular communication through connexin 43 in granulosa cells from patients with polycystic ovary syndrome
Authors: Jiang Linlin , Huang Hui , Qian Yifan , Li Yu , Chen Xiaoli , Di Na , Yang Dongzi 
Published: June 2020

Abstract
MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal menstrual cycle, and whether certain miRNAs regulate the Cx43 level and gap junctional intercellular communication (GJIC). The miRNA profile was investigated in ovarian cortex tissues from five women with PCOS and five women without PCOS using a miRNA microarray. The levels of miR-130b and Cx43 mRNA were measured using real-time PCR in human luteinized granulosa cells from 20 women with PCOS and 25 women without PCOS. Protein and mRNA expression analysis and luciferase assays were conducted to confirm the substrate of miR-130b. PCOS ovarian cortex showed differential expression of miRNAs compared with non-PCOS ovarian cortex. Furthermore, miR-130b levels were increased in PCOS ovarian cortex and in luteinized granulosa cells compared with those in women with normal menstrual cycles, whereas the level of Cx43 mRNA, the identified target of miR-130b, was decreased in granulosa cells from patients with PCOS. Overexpression of miR-130b in a granulosa cell line resulted in reduced Cx43 protein levels and inhibited GJIC using scrape loading and dye transfer assay. Meanwhile, inhibition of miR-130b increased the Cx43 level. In conclusion, miR-130b was increased in PCOS granulosa cells, where it targets Cx43 to affect GJIC. The results of the present study suggested that miR-130b, via post-transcriptional regulation of Cx43, is involved in the pathophysiology of PCOS, which provides new insight into the pathological mechanism of PCOS.
Small-molecule sensitization of RecBCD helicase–nuclease to a Chi hotspot-activated state
Authors: Karabulut Ahmet C , Cirz Ryan T , Taylor Andrew F , Smith Gerald R 
Published: June 2020

AbstractCoordinating multiple activities of complex enzymes is critical for life, including transcribing, replicating and repairing DNA. Bacterial RecBCD helicase–nuclease must coordinate DNA unwinding and cutting to repair broken DNA. Starting at a DNA end, RecBCD unwinds DNA with its fast RecD helicase on the 5′-ended strand and its slower RecB helicase on the 3′-ended strand. At Chi hotspots (5′ GCTGGTGG 3′), RecB’s nuclease cuts the 3′-ended strand and loads RecA strand-exchange protein onto it. We report that a small molecule NSAC1003, a sulfanyltriazolobenzimidazole, mimics Chi sites by sensitizing RecBCD to cut DNA at a Chi-independent position a certain percent of the DNA substrate's length. This percent decreases with increasing NSAC1003 concentration. Our data indicate that NSAC1003 slows RecB relative to RecD and sensitizes it to cut DNA when the leading helicase RecD stops at the DNA end. Two previously described RecBCD mutants altered in the RecB ATP-binding site also have this property, but uninhibited wild-type RecBCD lacks it. ATP and NSAC1003 are competitive; computation docks NSAC1003 into RecB’s ATP-binding site, suggesting NSAC1003 acts directly on RecB. NSAC1003 will help elucidate molecular mechanisms of RecBCD-Chi regulation and DNA repair. Similar studies could help elucidate other DNA enzymes with activities coordinated at chromosomal sites.
What binds us? Inter-brain neural synchronization and its implications for theories of human consciousness
Authors: Valencia Ana Lucía , Froese Tom 
Published: June 2020

AbstractThe association between neural oscillations and functional integration is widely recognized in the study of human cognition. Large-scale synchronization of neural activity has also been proposed as the neural basis of consciousness. Intriguingly, a growing number of studies in social cognitive neuroscience reveal that phase synchronization similarly appears across brains during meaningful social interaction. Moreover, this inter-brain synchronization has been associated with subjective reports of social connectedness, engagement, and cooperativeness, as well as experiences of social cohesion and ‘self-other merging’. These findings challenge the standard view of human consciousness as essentially first-person singular and private. We therefore revisit the recent controversy over the possibility of extended consciousness and argue that evidence of inter-brain synchronization in the fastest frequency bands overcomes the hitherto most convincing sceptical position. If this proposal is on the right track, our understanding of human consciousness would be profoundly transformed, and we propose a method to test this proposal experimentally.
A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels
Authors: Zhang Zhen , He Chaoliang , Rong Yan , Ren Hui , Wang Tianran , Zou Zheng , Chen Xuesi 
Published: June 2020

Abstract
Fast and catalyst-free cross-linking strategy is of great significance for construction of covalently cross-linked hydrogels. Here, we report the condensation reaction between o-phthalaldehyde (OPA) and N-nucleophiles (primary amine, hydrazide and aminooxy) for hydrogel formation for the first time. When four-arm poly(ethylene glycol) (4aPEG) capped with OPA was mixed with various N-nucleophile-terminated 4aPEG as building blocks, hydrogels were formed with superfast gelation rate, higher mechanical strength and markedly lower critical gelation concentrations, compared to benzaldehyde-based counterparts. Small molecule model reactions indicate the key to these cross-links is the fast formation of heterocycle phthalimidine product or isoindole (bis)hemiaminal intermediates, depending on the N-nucleophiles. The second-order rate constant for the formation of phthalimidine linkage (4.3 M−1 s−1) is over 3000 times and 200 times higher than those for acylhydrazone and oxime formation from benzaldehyde, respectively, and comparable to many cycloaddition click reactions. Based on the versatile OPA chemistry, various hydrogels can be readily prepared from naturally derived polysaccharides, proteins or synthetic polymers without complicated chemical modification. Moreover, biofunctionality is facilely imparted to the hydrogels by introducing amine-bearing peptides via the reaction between OPA and amino group.
Omega-3 fats in pregnancy: could a targeted approach lead to better metabolic health for children?
Authors: Satokar Vidit V , Cutfield Wayne S , Cameron-Smith David , Albert Benjamin B 
Published: June 2020

AbstractThe prevalence of childhood obesity is increasing worldwide, and the children of women who are obese during pregnancy are at greatest risk. This risk may be mediated by exaggeration of the normal insulin resistance of pregnancy. Omega-3 (n-3) fats are insulin sensitizing. Supplementation during pregnancy may reduce metabolic risk and adiposity in the children. Though results from animal studies are encouraging, completed clinical trials have not demonstrated this benefit. However, to our knowledge, previous studies have not targeted women who are overweight or obese while pregnant—the group at greatest risk for insulin resistance and most likely to benefit from n-3. In this narrative review, the importance of performing clinical trials restricted to women who are overweight or obese is discussed, as is the potential importance of n-3 dose, oil source and quality, and the timing of the intervention.
National Survey of US HIV Clinicians: Knowledge and Attitudes About the Affordable Care Act and Opinions of its Impact on Quality of Care and Barriers to Care
Authors: McManus Kathleen A , Ferey Joshua , Farrell Elizabeth , Dillingham Rebecca 
Published: June 2020

Abstract

Background
The Affordable Care Act’s (ACA’s) major reforms started in 2014. In addition to assessing HIV clinicians’ ACA knowledge and attitudes, this study aims to evaluate HIV clinicians’ perspectives on whether the ACA has impacted the quality of HIV care and whether it addresses the main barriers to HIV care.

Methods
HIV clinicians were emailed a survey weblink in 2018. Descriptive statistics, Mann-Whitney U tests, and binary logistic regression were performed.

Results
Of the 211 survey participants, the majority (70%) answered all 4 knowledge questions correctly. About 80% knew correctly whether their state had expanded Medicaid. Participants from Medicaid expansion states were more likely to report an improved ability to provide high-quality care compared with participants from Medicaid nonexpansion states (50% vs 34%; P = .01). The average response to whether the ACA addresses the main barriers to HIV care was neutral and did not differ based on Medicaid status. The top 3 main barriers to HIV care cited were mental health, substance use, and transportation.

Conclusions
HIV clinicians in Medicaid expansion states were more likely to report an improved ability to provide high-quality care since ACA implementation compared with those in Medicaid nonexpansion states. However, HIV clinicians across the United States are concerned that the ACA does not address the main barriers to HIV care. To be successful, the “Ending the HIV Epidemic” initiative should address these identified barriers.
L’imagerie cérébrale systématique du nouveau-né prématuré
Authors: Guillot Mireille , Chau Vann , Lemyre Brigitte 
Published: June 2020

Résumé
L’imagerie cérébrale systématique pour déceler les lésions touchant les nouveau-nés prématurés est utilisée pour prédire le pronostic à long terme et déterminer les complications susceptibles de nécessiter une intervention. Même si l’imagerie par résonance magnétique peut être indiquée dans des situations particulières, l’échographie cérébrale est la technique la plus utilisée et demeure la meilleure modalité d’imagerie systématique en raison de sa portabilité et de sa facilité d’accès. L’échographie cérébrale systématique est recommandée pour tous les nouveau-nés venus au monde à 31+6 semaines d’âge gestationnel ou auparavant. Chez les nouveau-nés prématurés venus au monde entre 32+0 et 36+6 semaines d’âge gestationnel l’échographie cérébrale systématique n’est recommandée qu’en présence de facteurs de risque d’hémorragie intracrânienne ou d’ischémie. Il est conseillé d’obtenir une imagerie cérébrale de quatre à sept jours après la naissance pour déceler la plupart des hémorragies de la matrice germinale et des hémorragies intraventriculaires. Il est recommandé de reprendre l’imagerie entre quatre et six semaines de vie pour déceler les lésions de la substance blanche. Chez les nouveau-nés prématurés venus au monde avant 26 semaines d’âge gestationnel, il est recommandé de reprendre l’échographie cérébrale à l’âge équivalant au terme.
Routine imaging of the preterm neonatal brain
Authors: Guillot Mireille , Chau Vann , Lemyre Brigitte 
Published: June 2020

Abstract
Routine brain imaging to detect injuries affecting preterm infants is used to predict long-term outcomes and identify complications that might necessitate an intervention. Although magnetic resonance imaging may be indicated in some specific cases, head ultrasound is the most widely used technique and, because of portability and ease of access, is the best modality for routine imaging. Routine head ultrasound examination is recommended for all infants born at or before 31+6 weeks gestation. For preterm neonates born between 32+0 to 36+6 weeks gestation, routine head ultrasound is recommended only in presence of risk factors for intracranial hemorrhage or ischemia. Brain imaging in the first 4 to 7 days postbirth is advised to detect most germinal matrix and intraventricular hemorrhages. Repeat imaging at 4 to 6 weeks of age is recommended to detect white matter injury. In preterm neonates born before 26 weeks gestation, a repeat HUS at term-equivalent age is recommended.
The Origins of Violence in Rwanda
Authors: Heldring Leander 
Published: June 2020

Abstract
This article shows that the intensity of violence in Rwanda’s recent past can be traced back to the initial establishment of its pre-colonial state. Villages that were brought under centralized rule one century earlier experienced a doubling of violence during the state-organized 1994 genocide. Instrumental variable estimates exploiting differences in the proximity to Nyanza—an early capital—suggest that these effects are causal. Before the genocide, when the state faced rebel attacks, with longer state presence, violence is lower. Using data from several sources, including a lab-in-the-field experiment across an abandoned historical boundary, I show that the effect of the historical state is primarily sustained by culturally transmitted norms of obedience. The persistent effect of the pre-colonial state interacts with government policy: where the state developed earlier, there is more violence when the Rwandan government mobilized for mass killing and less violence when the government pursued peace.
Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis
Authors: Lamichhane Santosh , Dickens Alex M , Sen Partho , Laurikainen Heikki , Borgan Faith , Suvisaari Jaana , Hyötyläinen Tuulia , Howes Oliver , Hietala Jarmo , Orešič Matej 
Published: June 2020

Abstract
Patients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic comorbidities. There is an unmet public health need to identify individuals with psychotic disorders who have a high risk of rapid weight gain and who are at risk of developing metabolic complications. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 healthy controls (CTR), 44 first-episode psychosis (FEP) patients, and 22 individuals at clinical high risk (CHR) for psychosis, from 2 study centers (Turku, Finland and London, UK). Baseline serum samples were analyzed using lipidomics, and body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols (TGs) with low double-bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of 2 TGs (TG[48:0] and TG[45:0]) was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic comorbidities.