bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Outcomes of Periprocedural Antithrombotic Therapy in Ischemic Priapism Management
Authors: Ramstein Joris J. , Lee Austin , Cohen Andrew J. , Mmonu Nnenaya A. , Rios Natalie , Enriquez Anthony , Shindel Alan W. , Lue Tom F. , Breyer Benjamin N. 
Published: August 2020

Abstract

Background
Priapism is a urologic emergency consisting of a painful erection lasting greater than 4 hours; antithrombotic therapy (ATT) have recently been recommended as an adjunct in the treatment of ischemic priapism.

Aim
To determine the short- and long-term outcomes of periprocedural ATT in the management of acute ischemic priapism.

Methods
A retrospective review of patients seen at the University of California, San Francisco, from 2008 to 2019 was carried out to identify those evaluated for acute priapism. Information regarding duration of priapism, etiology, treatment, periprocedural and postprocedural ATT type and dose, and follow-up data was collected.

Outcomes
ATT use was the exposure of interest; outcome variables included priapism resolution, repeat episodes, long-term complications, and follow-up.

Results
70 patients with at least 1 detailed record of an acute priapism episode between 2008 and 2019 were identified. Of the 70 patients who underwent management for an acute episode of priapism, 59 (84%) received intracavernous injection of phenylephrine with or without corporal aspiration. Of the 4 patients who received ATT at the same time as intracavernous injection, none had additional priapism episodes. In the 55 patients who did not receive immediate ATT, 22 (40%) required at least 1 shunting procedure. The 9 patients who received ATT concurrently with shunting experienced less recurrence than the 13 patients who did not receive ATT (11% vs 69%, respectively P = .012). There were no significant differences in long-term erectile dysfunction (P = .627), fibrosis (P = .118), genitourinary pain (P = .474), and urinary issues (P = .158) between those who received ATT and those who did not.

Clinical Implications
Our findings suggest that ATT has a role in preventing priapism recurrence; we observed that long-term repeat priapism episodes are less frequent in those who received periprocedural ATT compared with those who did not and that ATT may especially reduce recurrence in cases when shunting was required

Strengths & Limitations
This is the first study looking at the clinical outcomes of periprocedural ATT in the management of ischemic priapism. It is limited by the fact that it is a single-center study, types of ATT were heterogenous, and the exact timing of priapism management could not be measured for everyone.

Conclusion
In spite of its limitations, these preliminary findings are promising and warrant further exploration of the use of ATT in the management of ischemic priapism.
Poverty is the problem – not parents: so tell me, child protection worker, how can you help?
Authors: Bennett Kylie , Booth Andrew , Gair Susan , Kibet Rose , Thorpe Ros 
Published: August 2020

AbstractFamilies who attract the attention of child protection services most often have ongoing lived experiences of poverty, gender-based domestic and family violence, problematic substance use and, sometimes, formally diagnosed mental health conditions. Without broader contextual knowledge and understanding, particularly regarding ongoing poverty, decision-making by child protection workers often leads to the removal of children, while the family’s material poverty and experiences of violence remain unaddressed. Case studies are a common tool to succinctly capture complex contexts. In this article, we make explicit, through case examples and analysis, how poverty is almost always the backdrop to the presence of worrying risk factors before and during child protection intervention. Further, we expose the existential poverty that parents live with after they lose their children into care and which invariably exacerbates material poverty. In the final section, we consider the multi-faceted organisational poverty that blights the work environment of child protection workers, and we suggest strategies for improved practice with families living in poverty.
Insufficient dietary choline aggravates disease severity in a mouse model of Citrobacter rodentium-induced colitis
Authors: Ju Tingting , Kennelly John P. , Jacobs René L. , Willing Benjamin P. 
Published: August 2020

AbstractDietary choline, which is converted to phosphatidylcholine (PC) in intestinal enterocytes, may benefit inflammatory bowel disease patients who typically have reduced intestinal choline and PC. The present study investigated the effect of dietary choline supplementation on colitis severity and intestinal mucosal homoeostasis using a Citrobacter rodentium-induced colitis model. C57BL/6J mice were fed three isoenergetic diets differing in choline level: choline-deficient (CD), choline-sufficient (CS) and choline-excess (CE) for 3 weeks prior to infection with C. rodentium. The effect of dietary choline levels on the gut microbiota was also characterised in the absence of infection using 16S rRNA gene amplicon sequencing. At 7 d following infection, the levels of C. rodentium in CD mice were significantly greater than that in CS or CE groups (P < 0·05). CD mice exhibited greater damage to the surface epithelium and goblet cell loss than the CS or CE mice, which was consistent with elevated pro-inflammatory cytokine and chemokine levels in the colon. In addition, CD group exhibited decreased concentrations of PC in the colon after C. rodentium infection, although the decrease was not observed in the absence of challenge. Select genera, including Allobaculum and Turicibacter, were enriched in response to dietary choline deficiency; however, there was minimal impact on the total bacterial abundance or the overall structure of the gut microbiota. Our results suggest that insufficient dietary choline intake aggravates the severity of colitis and demonstrates an essential role of choline in maintaining intestinal homoeostasis.
The Epistle of James as a reception of Paul: Rehabilitating an epistle of straw
Authors: Eurell John-Christian 
Published: August 2020

AbstractThe Epistle of James is one of the most overlooked texts in the New Testament. This is partially due to Luther's judgement of the epistle as anti-Pauline. This article suggests that James should rather be seen as an early reception of Paul that brings new insight into the Pauline legacy of the late first century. James also helps us understand more about the theological issues of its day.
PERCEIVING THINGS IN THEMSELVES: ABŪ L-BARAKĀT AL-BAĠDĀDĪ’S CRITIQUE OF REPRESENTATIONALISM
Authors: Benevich Fedor 
Published: August 2020

AbstractWhat are the proper objects of perception? Two famous responses to this question hold that they are either the images of extramental objects, that is, the way in which they appear to us (representationalism), or they are the objects themselves (direct realism). In this paper, I present an analysis of this issue by Abū l-Barakāt al-Baġdādī (d. 1164/65), a post-Avicennian scholar whose impact on the history of Islamic philosophy has been largely neglected. Abū l-Barakāt argued against the traditional Aristotelian-Avicennian epistemological dualism, which distinguishes between the sense-perception of material particulars and the conception of immaterial universals in terms of the perceiver and/or the structure of perception. In Abū l-Barakāt's own theory, all epistemic acts have the unified structure of direct relation between one and the same perceiver (immaterial soul) and the objects themselves – both material and immaterial. His main thesis is that having corporeal organs is not necessary for sense-perception. In the final section of the paper, I show that Abū l-Barakāt's critique of the Aristotelian-Avicennian tradition was received as a breakthrough in epistemology. It may have also determined the epistemological theories of two of the most important post-Avicennian Islamic philosophers: Faḫr al-Dīn al-Rāzī (d. 1210) and Šihāb al-Dīn al-Suhrawardī (d. 1191).
Many disjoint triangles in co-triangle-free graphs
Authors: Tyomkyn Mykhaylo 
Published: August 2020

AbstractWe prove that any n-vertex graph whose complement is triangle-free contains n2/12 – o(n2) edge-disjoint triangles. This is tight for the disjoint union of two cliques of order n/2. We also prove a corresponding stability theorem, that all large graphs attaining the above bound are close to being bipartite. Our results answer a question of Alon and Linial, and make progress on a conjecture of Erdős.
Hybrid perventricular muscular ventricular septal defect closure using the new multi-functional occluder
Authors: Haddad Raymond N. , Gaudin Régis , Bonnet Damien , Malekzadeh-Milani Sophie 
Published: August 2020

AbstractThe hybrid perventricular approach for the closure of trabecular ventricular septal defects is an attractive treatment modality for small children. Worldwide experience has shown that procedure success is influenced by the defect anatomical accessibility, operators’ expertise, and device technical features. In May 2018, a new promising device, the KONAR-Multi-functional™ ventricular septal defect occluder (Lifetech, Shenzhen, China), obtained CE-marking for septal defect transcatheter closure after the first-in-man implantation in 2013. Herein, this is the first report of successful perventricular closure of ventricular septal defect using this new device in a child with significant co-morbidities.
A review of the effects of tobacco smoking on the treatment of prostate cancer
Authors: Nuru Faiza , Osei Ernest , Kassim Rahil 
Published: August 2020

AbstractBackground:Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of death among Canadian men. The standard treatment modalities for prostate cancer include prostatectomy, radiation therapy, hormonal therapy and chemotherapy or any combination depending on the stage of the tumour. However, several studies have reported that tobacco smoking at the time of diagnosis and during treatment can potentially impact treatment efficacy, outcome and patients quality of life after treatment.Materials and methods:This narrative literature review elucidates the impacts of tobacco smoking on prostate cancer progression, treatment efficacy, including its effects on prostatectomy, radiation therapy and chemotherapy, risk of cancer recurrence and mortality and quality of life after treatment. Furthermore, we discuss the importance of integrating a smoking cessation programme into the treatment regimen for prostate cancer patients in order to yield more favourable treatment outcomes, reduce risk of recurrence and mortality and increase the quality of life after treatment for prostate cancer patients.Conclusions:Smoking cessation is one of the most important interventions to prevent cancer and it is also essential after the diagnosis of prostate cancer to improve clinical outcomes. All prostate cancer patients should be advised to quit tobacco use since it can potentially improve treatment response rates and survival, as well as reduce the risk of developing treatment complications and potentially improve the quality of life after treatment. There are several benefits to smoking cessation and it should become an important component of the cancer care continuum in all oncology programmes, starting from prevention of cancer through diagnosis, treatment, survivorship and palliative care. Evidence-based smoking cessation intervention should be sustainably integrated into any comprehensive cancer programme, and the information should be targeted to the specific benefits of cessation in cancer patients.
News Coverage of Child Care during COVID-19: Where Are Women and Gender?
Authors: Wallace Rebecca , Goodyear-Grant Elizabeth 
Published: August 2020

AbstractResearch has long observed the absence of gender in child care policy, media, and elections. However, the COVID-19 pandemic has invoked critical questions about child care and its importance to states’ economic recoveries around the world. In this research note, we analyze news coverage of child care in major Canadian daily newspapers to explore whether and how news narratives regarding child care are shifting in light of the COVID-19 pandemic. In particular, are we seeing a focus on women and gender in child care coverage amid the compounding pressures that women face in the current social and economic climate? The results of our analysis suggest that the pandemic has not shifted the conversation on child care and that current coverage principally reflects long-standing trends in child care framing. We find that gender remains systematically written out of coverage of child care, occluded by a larger focus on health-, economic-, and accessibility-related concerns about child care services.
Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial
Authors: Derosa Giuseppe , D’Angelo Angela , Martinotti Chiara , Valentino Maria Chiara , Di Matteo Sergio , Bruno Giacomo M. , Maffioli Pamela 
Published: August 2020

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.
Bifurcated Crustal Channel Flow and Seismogenic Structures of Intraplate Earthquakes in Western Yunnan, China as Revealed by Three‐Dimensional Magnetotelluric Imaging
Authors: Ye Tao , Chen Xiaobin , Huang Qinghua , Zhao Li , Zhang Yong , Uyeshima Makoto 
Published: August 2020

AbstractBased on broadband magnetotelluric data collected in western Yunnan, we obtain a three‐dimensional crustal resistivity model, which reveals seismogenic structures of Yingjiang and Longling earthquakes. Our model suggests a bifurcation of the crustal flow in western Yunnan, with a southwestern branch running into the Tengchong Block north of the Dayingjiang Fault and a southeastern branch flowing into the Baoshan Block. The Yingjiang region features an upper and midcrustal resistive body above 20‐km depth, surrounded by conductors in the midcrust. Six moderate earthquakes in Yingjiang occurred in the transition zone between the resistive and conductive structures. These earthquakes occurred in the context of a right‐lateral accommodation zone between the Nabang and Binglangjiang Faults and in the presence of the southwestern branch of the crustal flow, which provides a mechanical decoupling under the rigid high‐resistive upper crust. Beneath the Longling area, a high‐resistive structure extends through the entire crust, but a zone of low resistivity is embedded in the depth range of 10–25 km where the 1976 M7.3 earthquake occurred. The high‐resistive body provides a blockage to the previously proposed crustal channel flow along the Gaoligong shear zone and may accumulate sufficient stress. The Longling strong earthquakes may result from the sinistral strike‐slip motion of the Ruili‐Luxi Fault in the framework of the north to northeast trending compressive stress. The blockage to the crustal channel flow along the Gaoligong shear zone by the high‐resistivity zone in Longling could be an important factor to produce the north to northeast trending compressive stress field in Longling area.
The Upper Tail of Precipitation in Convection‐Permitting Regional Climate Models and Their Utility in Nonstationary Rainfall and Flood Frequency Analysis
Authors: Yu Guo , Wright Daniel B. , Li Zhe 
Published: August 2020

AbstractComputational advances have made atmospheric modeling at convection‐permitting (≤4 km) grid spacings increasingly feasible. These simulations hold great promise in the projection of climate change impacts including rainfall and flood extremes. The relatively short model runs that are currently feasible, however, inhibit the assessment of the upper tail of rainfall and flood quantiles using conventional statistical methods. Stochastic storm transposition (SST) and process‐based flood frequency analysis are two approaches that together can help to mitigate this limitation. SST generates large numbers of extreme rainfall scenarios by temporal resampling and geospatial transposition of rainfall fields from relatively short data sets. Coupling SST with process‐based flood frequency analysis enables exploration of flood behavior at a range of spatial and temporal scales. We apply these approaches with outputs of 13‐year simulations of regional climate to examine changes in extreme rainfall and flood quantiles up to the 500‐year recurrence interval in a medium‐sized watershed in the Midwestern United States. Intensification of extreme precipitation across a range of spatial and temporal scales is identified in future climate; changes in flood magnitudes depend on watershed area, with small watersheds exhibiting the greatest increases due to their limited capacity to attenuate flood peaks. Flood seasonality and snowmelt are predicted to be earlier in the year under projected warming, while the most extreme floods continue to occur in early summer. Findings highlight both the potential and limitations of convection‐resolving climate models to help understand possible changes in rainfall and flood frequency across watershed scales.
Low‐Temperature Thermochronology of the Indus Basin in Central Ladakh, Northwest India: Implications of Miocene‐Pliocene Cooling in the India‐Asia Collision Zone
Authors: Bhattacharya Gourab , Robinson Delores M. , Orme Devon A. , Najman Yani , Carter Andrew 
Published: August 2020

AbstractThe India‐Asia collision zone in Ladakh, northwest India, records a sequence of tectono‐thermal events in the interior of the Himalayan orogen following the intercontinental collision between India and Asia in early Cenozoic time. We present zircon fission track, and zircon and apatite (U‐Th)/He thermochronometric data from the Indus Basin sedimentary rocks that are exposed along the strike of the collision zone in central Ladakh. These data reveal a postdepositional Miocene‐Pliocene (~22–4 Ma) cooling signal along the India‐Asia collision zone in northwest India. Our zircon fission track cooling ages indicate that maximum basin temperatures exceeded 200°C but stayed below 280–300°C in the stratigraphically deeper marine and continental strata. Thermal modeling of zircon and apatite (U‐Th)/He cooling ages suggests postdepositional basin cooling initiated in Early Miocene time by ~22–20 Ma, occurred throughout the basin across zircon (U‐Th)/He partial retention temperatures from ~20–10 Ma, and continued in the Pliocene time until at least ~4 Ma. We attribute the burial of the Indus Basin to sedimentation and movement along the regional Great Counter thrust. The ensuing Miocene‐Pliocene cooling resulted from erosion by the Indus River that transects the basin. An approximately coeval cooling signal is well documented east of the study area, along the collision zone in south Tibet. Our new data provide a regional framework upon which future studies can explore the possible interrelationships between tectonic, geodynamic, and geomorphologic factors contributing to Miocene‐Pliocene cooling along the India‐Asia collision zone from NW India to south Tibet.
BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation
Authors: Reischmann Nadine , Andrieux Geoffroy , Griffin Ricarda , Reinheckel Thomas , Boerries Melanie , Brummer Tilman 
Published: August 2020

AbstractBRAFV600E confers poor prognosis and is associated with a distinct subtype of colorectal cancer (CRC). Little is known, however, about the genetic events driving the initiation and progression of BRAFV600E mutant CRCs. Recent genetic analyses of CRCs indicate that BRAFV600E often coexists with alterations in the WNT- and p53 pathways, but their cooperation remains ill-defined. Therefore, we systematically compared small and large intestinal organoids from mice harboring conditional BraffloxV600E, Trp53LSL-R172H, and/or Apcflox/flox alleles. Using these isogenic models, we observe tissue-specific differences toward sudden BRAFV600E expression, which can be attributed to different ERK-pathway ground states in small and large intestinal crypts. BRAFV600E alone causes transient proliferation and suppresses epithelial organization, followed by organoid disintegration. Moreover, BRAFV600E induces a fetal-like dedifferentiation transcriptional program in colonic organoids, which resembles human BRAFV600E-driven CRC. Co-expression of p53R172H delays organoid disintegration, confers anchorage-independent growth, and induces invasive properties. Interestingly, p53R172H cooperates with BRAFV600E to modulate the abundance of transcripts linked to carcinogenesis, in particular within colonic organoids. Remarkably, WNT-pathway activation by Apc deletion fully protects organoids against BRAFV600E-induced disintegration and confers growth/niche factor independence. Still, Apc-deficient BRAFV600E-mutant organoids remain sensitive toward the MEK inhibitor trametinib, albeit p53R172H confers partial resistance against this clinically relevant compound. In summary, our systematic comparison of the response of small and large intestinal organoids to oncogenic alterations suggests colonic organoids to be better suited to model the human situation. In addition, our work on BRAF-, p53-, and WNT-pathway mutations provides new insights into their cooperation and for the design of targeted therapies.