bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apathy symptoms increase the risk of dementia conversion: a case‐matching cohort study on patients with post‐stroke mild cognitive impairment in China
Authors: Zhao Jiayi , Jin Xianglan , Chen Baoxin , Fu Chen , Ji Shaozhen , Shen Wei , Wei Jingjing , Zheng Hong , Zhang Yunling 
Published: January 2021

AbstractBackgroundApathy is a neuropsychiatric symptom frequently observed in patients with cognitive impairment. It has been found to be a predictor of conversion from mild cognitive impairment (MCI) to dementia of Alzheimer disease type. However, this association between apathy and dementia conversion has not yet been confirmed in vascular MCI, especially post‐stroke MCI. The aim of this study was to evaluate whether apathy would increase the risk of dementia conversion in patients with post‐stroke MCI after 6 months.MethodA prospective multi‐centre cohort study was performed in 14 clinics in seven provinces and cities of China. A total of 989 subjects were included 2 weeks to 6 months after stroke, and met the diagnostic criteria of International Working Group for MCI. Symptoms of apathy were assessed using the apathy subscale of Geriatric Depression Scale. Subjects were divided into an apathy group (n = 128) and a non‐apathy group (n = 861). The primary outcome was the dementia conversion after 6 months. To eliminate potential biases, subjects were chosen from 861 non‐apathy patients with similarity in seven potential predictors of cognitive impairment to match with the apathy group (n = 128) at a 1:1 ratio, as a matched non‐apathy group (n = 128). The dementia conversion rate was compared between the apathy group (n = 128) and its correspondingly matched non‐apathy group (n = 128), and the relative risk (RR) was calculated.ResultsThe prevalence of apathy in post‐stroke MCI was 12.9%. After 6 months, 5.2% of patients with post‐stroke MCI converted to dementia. The dementia conversion rate of the apathy group was significantly higher than that of the non‐apathy group before case‐matching (17.2% vs 3.4%, P < 0.001), and also after case‐matching (17.2% vs 6.3%, P < 0.001). Symptoms of apathy increased the risk of conversion from MCI to dementia (RR 2.75, 95% CI 1.272–5.947, P < 0.001).ConclusionsFor patients with post‐stroke MCI, apathy symptoms increase the risk of conversion from MCI to dementia.
A Maximal Rowing Ergometer Protocol to Predict Maximal Oxygen Uptake
Authors: Jensen Kurt , Frydkjær Morten , Jensen Niels M.B. , Bannerholt Lucas M. , Gam Søren 
Published: January 2021

Purpose: To examine the relationship between the maximal power output (MPO) in an individualized 7 × 2-minute incremental (INCR) test, average power in a 2k (W2k) rowing ergometer test, and maximal oxygen uptake () and to develop a regression equation to predict . Methods: A total of 34 male club rowers (age 18–30 y) performed a 2k and an INCR test in a Concept2 rowing ergometer to determine and compare MPO, W2k, and . Results: No significant difference was found between measured during INCR or 2k test (P = .73). A very high correlation coefficient (r = .96) was found between MPO and and between W2k and (r = .93). Linear regression analyses were developed for predicting from MPO: (1) (mL·min−1) = 11.49 × MPO + 810 and from W2k: (2)  = 10.96 × W2k + 1168. Cross-validation analyses were performed using an independent sample of 14 rowers. There was no difference between the mean predicted in the INCR test (4.41 L·min−1) or the 2k test (4.39 L·min−1) and the observed (4.40 L·min−1). Technical error of measurement was 3.1% and 3.6%, standard error of estimate was 0.136 and 0.157 mL·min−1, and validation coefficients (r) were .95 and .94 using Equation (1) and (2), respectively. Conclusion: A prediction model only including MPO or W2k explains 88% to 90% of the variability in and is suggested for practical use in male club rowers.
Hospital readmission among people experiencing homelessness in England: a cohort study of 2772 matched homeless and housed inpatients
Authors: Lewer Dan , Menezes Dee , Cornes Michelle , Blackburn Ruth M , Byng Richard , Clark Michael , Denaxas Spiros , Evans Hannah , Fuller James , Hewett Nigel , Kilmister Alan , Luchenski Serena April , Manthorpe Jill , McKee Martin , Neale Joanne , Story Alistair , Tinelli Michela , Whiteford Martin , Wurie Fatima , Yavlinsky Alexei , Hayward Andrew , Aldridge Robert 
Published: January 2021

BackgroundInpatients experiencing homelessness are often discharged to unstable accommodation or the street, which may increase the risk of readmission.MethodsWe conducted a cohort study of 2772 homeless patients discharged after an emergency admission at 78 hospitals across England between November 2013 and November 2016. For each individual, we selected a housed patient who lived in a socioeconomically deprived area, matched on age, sex, hospital, and year of discharge. Counts of emergency readmissions, planned readmissions, and Accident and Emergency (A&E) visits post-discharge were derived from national hospital databases, with a median of 2.8 years of follow-up. We estimated the cumulative incidence of readmission over 12 months, and used negative binomial regression to estimate rate ratios.ResultsAfter adjusting for health measured at the index admission, homeless patients had 2.49 (95% CI 2.29 to 2.70) times the rate of emergency readmission, 0.60 (95% CI 0.53 to 0.68) times the rate of planned readmission and 2.57 (95% CI 2.41 to 2.73) times the rate of A&E visits compared with housed patients. The 12-month risk of emergency readmission was higher for homeless patients (61%, 95% CI 59% to 64%) than housed patients (33%, 95% CI 30% to 36%); and the risk of planned readmission was lower for homeless patients (17%, 95% CI 14% to 19%) than for housed patients (30%, 95% CI 28% to 32%). While the risk of emergency readmission varied with the reason for admission for housed patients, for example being higher for admissions due to cancers than for those due to accidents, the risk was high across all causes for homeless patients.ConclusionsHospital patients experiencing homelessness have high rates of emergency readmission that are not explained by health. This highlights the need for discharge arrangements that address their health, housing and social care needs.
After the bell: adolescents’ organised leisure-time activities and well-being in the context of social and socioeconomic inequalities
Authors: Badura Petr , Hamrik Zdenek , Dierckens Maxim , Gobiņa Inese , Malinowska-Cieślik Marta , Furstova Jana , Kopcakova Jaroslava , Pickett William 
Published: January 2021

BackgroundPrevious research has linked adolescents’ participation in organised leisure-time activities (OLTAs) to better health and well-being. It remains unclear whether these associations can be observed consistently across social and socioeconomic strata and countries.MethodsThe present study used nine nationally representative samples of adolescents aged 11, 13 and 15 years (total n=55 429) from the 2017/2018 Health Behaviour in School-aged Children survey from Europe and Canada. Regression models with mixed effects to account for nested nature of data were applied to estimate: (1) the associations of social and socioeconomic factors with OLTA participation; (2) strengths of the associations between breadth and pattern of OLTA participation with health and well-being indicators, after adjustment for the social and socioeconomic factors.ResultsRates of OLTA participation varied by age, sex and country of adolescents. Participants from lower socioeconomic classes and non-nuclear families were less likely to participate in OLTAs across each of the nine countries. Moreover, breadth of OLTA participation was associated with higher well-being independent of socioeconomic status or family structure. All of the participation patterns were associated with higher life satisfaction, but sports (either alone or in combination with a non-sport OLTA) were also associated with fewer psychological complaints and excellent self-rated health.ConclusionAdolescents’ engagement in OLTAs was associated with adolescents’ subjective well-being regardless of country, age, sex and variance in social and socioeconomic factors. Policies aimed at increasing adolescents’ subjective well-being and OLTA participation should focus on adolescents from low socioeconomic classes and non-nuclear families.
Longitudinal Doppler effect in de Sitter expanding universe
Authors: Cotăescu Ion I. 
Published: January 2021

A new redshift formula is obtained considering the longitudinal Doppler effect in the de Sitter expanding universe where the relative geodesic motion is governed by the Lorentzian isometries of our new de Sitter relativity [I. I. Cotăescu, Eur. Phys. J. C 77, 485 (2017)]. This formula combines in a nontrivial manner the well-known cosmological contribution given by Lamaître’s law with that of the relative motion of the source with respect to a fixed observer as in de Sitter relativity instead of special relativity. Other related quantities as the dispersion relation, the propagation time of the photon and the real distance between the source and observer at the moment of observation are discussed pointing out their specific features in the de Sitter relativity.
Multicohort Metabolomics Analysis Discloses 9‐Decenoylcarnitine to Be Associated With Incident Atrial Fibrillation
Authors: Lind Lars , Salihovic Samira , Sundström Johan , Broeckling Corey D. , Magnusson Patrik K. , Prenni Jessica , Fall Tove , Ärnlöv Johan 
Published: January 2021

Background
The molecular mechanisms involved in atrial fibrillation are not well known. We used plasma metabolomics to investigate if we could identify novel biomarkers and pathophysiological pathways of incident atrial fibrillation.

Methods and Results

We identified 200 endogenous metabolites in plasma/serum by nontargeted ultra‐performance liquid chromatography coupled to time‐of‐flight mass spectrometry in 3 independent population‐based samples (TwinGene, n=1935, mean age 68, 43% females; PIVUS [Prospective Investigation of the Vasculature in Uppsala Seniors], n=897, mean age 70, 51% females; and ULSAM [Uppsala Longitudinal Study of Adult Men], n=1118, mean age 71, all males), with available data on incident atrial fibrillation during 10 to 12 years of follow‐up. A meta‐analysis of ULSAM and PIVUS was used as a discovery sample and TwinGene was used for validation. In PIVUS, we also investigated associations between metabolites of interest and echocardiographic indices of myocardial geometry and function. Genome‐wide association studies were performed in all 3 cohorts for metabolites of interest. In the meta‐analysis of PIVUS and ULSAM with 430 incident cases, 4 metabolites were associated with incident atrial fibrillation at a false discovery rate <5%. Of those, only 9‐decenoylcarnitine was associated with incident atrial fibrillation and replicated in the TwinGene sample (288 cases) following adjustment for traditional risk factors (hazard ratio, 1.24 per unit; 95% CI, 1.06–1.45,
P
=0.0061). A meta‐analysis of all 3 cohorts disclosed another 4 significant metabolites. In PIVUS, 9‐decenoylcarnitine was related to left atrium size and left ventricular mass. A Mendelian randomization analysis did not suggest a causal role of 9‐decenoylcarnitine in atrial fibrillation.

Conclusions
A nontargeted metabolomics analysis disclosed 1 novel replicated biomarker for atrial fibrillation, 9‐Decenoylcarnitine, but this acetylcarnitine is likely not causally related to atrial fibrillation.
Augustine on Active Perception, Awareness, and Representation
Authors: Nawar Tamer 
Published: January 2021

Abstract
It is widely thought that Augustine thinks perception is, in some distinctive sense, an active process and that he takes conscious awareness to be constitutive of perception. I argue that conscious awareness is not straightforwardly constitutive of perception and that Augustine is best understood as an indirect realist. I then clarify Augustine’s views concerning the nature and role of diachronically unified conscious awareness and mental representation in perception, the nature of the soul’s intentio, and the precise sense(s) in which perception is an active process.
The Aural Impact of Solecisms in Revelation
Authors: Best Garrett 
Published: January 2021

Abstract
Scholars have proposed as many as 232 solecisms (morpho-syntactical errors) within the Greek of the Apocalypse. One of the great paradoxes of the book is its astonishing complexity expressed in such irregular Greek. While numerous scholars have sought to account for and explain the solecisms in Revelation, few have explored the aural dimension. Since the book was designed to be read aloud to early churches in Asia, it is important to investigate how irregular grammar would have affected the first hearers. This paper attempts to fill this lacuna by examining how solecisms were viewed in the ancient world and how ancients responded when lectors made mistakes in reading. This paper will then draw on the insights of ancient rhetorical handbooks to provide new insight into the irregular grammar of Revelation.
Provenance and the Holy Grail of Purpose in Recent Markan Research
Authors: Jensen Morten Hørning 
Published: January 2021

Abstract
Since Willi Marxsen’s break with the consensus view that the Gospel of Mark was most probably written in Rome, the question of provenance has played a crucial role in discussions of Mark’s purpose. While several researchers (most notably Dwight Peterson) have pointed out how using provenance as the hermeneutical key to Mark may involve a risk of circular reasoning, recent contributions have tied discussions of Mark’s purpose ever more tightly to the question of where the gospel was written. After outlining these recent research developments, this article argues for an alternative way of handling the question of Mark’s provenance, one that emphasizes how the major themes of Mark’s gospel touch upon longstanding issues within Second Temple Judaism, which means that a particular provenance is not needed as a hermeneutical crutch for establishing Mark’s purpose.
Alessandro Bausani and ‘Muslim Languages’, Forty Years After
Authors: Rossi Adriano V. 
Published: January 2021

Abstract
Resorting to personal memories from the 1960s, 1970s and 1980s, the author, who defended in 1971 at the University of Rome a thesis entitled Iranian Elements in Brahui, under Prof. Bausani’s direction (later revised and published under the title Iranian lexical elements in Brāhūī [Naples: Istituto Universitario Orientale, 1979]), reconstructs the political and cultural climate in which – at the end of the 1970s – a major subject of enquiry was the problem of the nature of the national unity among the countries of the Arab world.
At the urging of Biancamaria Scarcia, Bausani decided to publish at the Institute of Islamic Studies of the University of Rome a volume of historical and linguistic essays coordinated by himself and B. Scarcia (Mondo islamico tra interazione e acculturazione [Roma: Istituto di studi islamici, 1981]). In this volume, Bausani published an essay on the concept of ‘Islamic language’ that took stock of his previous proposals made over more than twenty years (starting with his speech at the 1966 Ravello conference on a comparative history of the Islamic literatures).
The author demonstrates that notwithstanding his use of linguistic terminology, Bausani’s main interest has always been the investigation of the possibility of identifying minimum distinctive traits present in the different literary typologies of various countries of Islamic culture.
Comparison of adverse perinatal outcomes between Asians and Caucasians: a population-based retrospective cohort study in Ontario
Authors: Zeng Na , Erwin Erica , Wen Wendy , Corsi Daniel J. , Wen Shi Wu , Guo Yanfang 
Published: January 2021

Abstract
Background
Racial disparities in adverse perinatal outcomes have been studied in other countries, but little has been done for the Canadian population. In this study, we sought to examine the disparities in adverse perinatal outcomes between Asians and Caucasians in Ontario, Canada.

Methods
We conducted a population-based retrospective cohort study that included all Asian and Caucasian women who attended a prenatal screening and resulted in a singleton birth in an Ontario hospital (April 1st, 2015-March 31st, 2017). Generalized estimating equation models were used to estimate the independent adjusted relative risks and adjusted risk difference of adverse perinatal outcomes for Asians compared with Caucasians.

Results
Among 237,293 eligible women, 31% were Asian and 69% were Caucasian. Asians were at an increased risk of gestational diabetes mellitus, placental previa, early preterm birth (< 32 weeks), preterm birth, emergency cesarean section, 3rd and 4th degree perineal tears, low birth weight (< 2500 g, < 1500 g), small-for-gestational-age (<10th percentile, <3rd percentile), neonatal intensive care unit admission, and hyperbilirubinemia requiring treatment, but had lower risks of preeclampsia, macrosomia (birth weight > 4000 g), large-for-gestational-age neonates, 5-min Apgar score < 7, and arterial cord pH ≤7.1, as compared with Caucasians. No difference in risk of elective cesarean section was observed between Asians and Caucasians.

Conclusion
There are significant differences in several adverse perinatal outcomes between Asians and Caucasians. These differences should be taken into consideration for clinical practices due to the large Asian population in Canada.
The surgical treatment of non-metastatic melanoma in a Clinical National Melanoma Registry Study Group (CNMR): a retrospective cohort quality improvement study to reduce the morbidity rates
Authors:   on behalf of the Clinical National Melanoma Registry Study Group at the Italian Melanoma Intergroup (IMI), Vecchiato Antonella , Mocellin Simone , Del Fiore Paolo , Tosti Giulio , Ascierto Paolo A. , Corradin Maria Teresa , De Giorgi Vincenzo , Giudice Giuseppe , Queirolo Paola , Ferreli Caterina , Occelli Marcella , Giordano Monica , Trevisan Giusto , Mascheroni Luigi , Testori Alessandro , Spina Romina , Buja Alessandra , Cavallin Francesco , Caracò Corrado , Sommariva Antonio , Rossi Carlo Riccardo 
Published: January 2021

Abstract
Background
Reproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still limited. This study presents the quality indicators on morbidity after surgical treatment for non-metastatic skin melanoma in an Italian registry.

Methods
Data were extracted from the Central National Melanoma Registry (CNMR) promoted by the Italian Melanoma Intergroup (IMI). All surgical procedures (WE, SNLB or LFND) for non-metastatic skin melanoma between January 2011 and February 2017 were evaluated for inclusion in the study. Only centers with adequate completeness of information (> 80%) were included in the study. Short-term complications (wound infection, dehiscence, skin graft failure and seroma) were investigated.

Results
Wound infection rate was 1.1% (0.4 to 2.7%) in WE, 1.3% (0.7 to 2.5%) in SLNB and 4.1% (2.1 to 8.0%) in LFND. Wound dehiscence rate was 2.0% (0.8 to 5.1%) in WE, 0.9% (0.2 to 3.0%) in SLNB and 2.8% (0.9 to 8.6%) in LFND. Seroma rate was 4.2% (1.5 to 11.1%) in SLNB and 15.1% (4.6 to 39.9%) in LFND. Unreliable information was found on skin graft failure.

Conclusions
Our findings contribute to available literature in setting up the recommended standards for melanoma centers, thus improving the quality of surgery offered to patients. A consensus on the core issues around surgical morbidity is needed to provide practical guidance on morbidity prevention and management.
MiR-608 overexpression in idiopathic pulmonary fibrosis (IPF)
Authors: Epstein Shochet Gali , Israeli-Shani Lilach , Kains Isabelle , Wand Ori , Shitrit David 
Published: January 2021

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease that causes scarring of the lungs. The disease is associated with the usual interstitial pneumonia pattern, which was not yet fully recapitulated by an animal model. Therefore, the disease is considered ‘human specific’. miRNA-608 is a primate specific miRNA with many potential targets, such CdC42 and Interlukin-6 (IL-6) that were previously implicated in IPF pathology.

Objective
To test miR-608 expression and its targets in IPF patient samples.

Methods
RNA was extracted from Formalin fixed paraffin embedded tissue sections (N = 18). miRNA-608 and Cdc42 and IL-6 levels were analyzed by qPCR. Acetylcholinesterase (AChE) is another target of miRNA-608. Its’ rs17228616 allele has a single-nucleotide polymorphism causing weakened miR-608 interaction (C2098A). Thus, DNA was extracted from whole blood samples from 56 subjects with fibrosing interstitial lung disease and this region was sequenced for assessment of rs17228616 allele polymorphism.

Results
miR-608 is significantly overexpressed in IPF samples in comparison with controls (p < 0.05). Cdc42 and IL-6 levels were lower in the IPF patient samples compared with control samples (p < 0.001 and p < 0.05, respectively). The frequency of the rs17228616 minor A-allele was 17/56 (30.4%) with all patients being heterozygous. This result is significant vs. the published Israeli cohort of healthy individuals, which reported 17% prevalence of this allele in healthy control volunteers (p = 0.01, OR = 2.1, CI 95% [1.19–3.9]).

Conclusion
miR-608 is overexpressed in IPF patients. While the exact mechanism remains to be discovered, it could potentially promote fibrotic disease.
Widespread occurrence of microRNA-mediated target cleavage on membrane-bound polysomes
Authors: Yang Xiaoyu , You Chenjiang , Wang Xufeng , Gao Lei , Mo Beixin , Liu Lin , Chen Xuemei 
Published: January 2021

AbstractBackgroundSmall RNAs (sRNAs) including microRNAs (miRNAs) and small interfering RNAs (siRNAs) serve as core players in gene silencing at transcriptional and post-transcriptional levels in plants, but their subcellular localization has not yet been well studied, thus limiting our mechanistic understanding of sRNA action.ResultsWe investigate the cytoplasmic partitioning of sRNAs and their targets globally in maize (Zea mays, inbred line “B73”) and rice (Oryza sativa, cv. “Nipponbare”) by high-throughput sequencing of polysome-associated sRNAs and 3′ cleavage fragments, and find that both miRNAs and a subset of 21-nucleotide (nt)/22-nt siRNAs are enriched on membrane-bound polysomes (MBPs) relative to total polysomes (TPs) across different tissues. Most of the siRNAs are generated from transposable elements (TEs), and retrotransposons positively contributed to MBP overaccumulation of 22-nt TE-derived siRNAs (TE-siRNAs) as opposed to DNA transposons. Widespread occurrence of miRNA-mediated target cleavage is observed on MBPs, and a large proportion of these cleavage events are MBP-unique. Reproductive21PHAS(21-nt phasiRNA-generating) and24PHAS(24-nt phasiRNA-generating) precursors, which were commonly considered as noncoding RNAs, are bound by polysomes, and high-frequency cleavage of21PHASprecursors by miR2118 and24PHASprecursors by miR2275 is further detected on MBPs. Reproductive 21-nt phasiRNAs are enriched on MBPs as opposed to TPs, whereas 24-nt phasiRNAs are nearly completely devoid of polysome occupancy.ConclusionsMBP overaccumulation is a conserved pattern for cytoplasmic partitioning of sRNAs, and endoplasmic reticulum (ER)-bound ribosomes function as an independent regulatory layer for miRNA-induced gene silencing and reproductive phasiRNA biosynthesis in maize and rice.