bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Patents on the Development of c-Met Kinase Inhibitors
Authors: Xu Xiangming , Yao Lei 
Published: June 2020

Background :
Receptor Tyrosine Kinases (RTKs) play critical roles in a variety of cellular
processes including growth, differentiation and angiogenesis, and in the development and progression
of many types of cancer. Mesenchymal-Epithelial Transition Factor (c-Met) kinase is one
of the types of RTKs and has become an attractive target for anti-tumor drug designing. c-Met inhibitors
have a broad prospect in tumor prevention, chemotherapy, biotherapy, and especially in tumor
resistance.

Objective:
The purpose of this article is to review recent research progress of c-Met inhibitors reported
in patents since 2015.

Methods:
A comprehensive Scifinder and Web of Science literature review was conducted to identify
all c-Met inhibitors published in patents since 2015.

Results:
There are two kinds of c-Met inhibitors, one is from natural products, and the other one is
of synthetic origin. Most of these c-Met inhibitors show potent in vivo and in vitro antitumor activities
and have potential in the treatment of cancers.

Conclusion:
c-Met kinase inhibitors have emerged as an exciting new drug class for the treatment
of all kinds of cancers, especially the Non-Small Cell Lung Cancer (NSCLC) with tumor resistance.
More studies should be conducted on natural products to find novel c-Met kinase inhibitors.
Modulation of MicroRNAs byEuphorbia MicrosciadiaBoiss in MDA-MB-231 Cell Line: New Possibilities in Breast Cancer Therapy
Authors: Mahmoudian-Sani Mohammad-Reza , Asadi-Samani Majid 
Published: June 2020

Background:A large number of Euphorbia species have been evaluated for anticancer effects; however, their anticancer mechanisms have not been established up to now.Objective:: The present study aimed to evaluate the effects of Euphorbia microsciadia (E. microsciadia) Boiss on the modulation of micro (mi) RNAs in MDA-MB-231 cell line.Methods:As the first step, the inhibitory concentration of hydroalcoholic extract of E. microsciadia on MDA-MB-231 cells was examined using the MTT assay, bypassing 24 and 48h from seeding. The real-time quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) was also utilized to determine Let-7, miR-15, miR-16, miR-29, miR-151, miR-155, miR-21, miR-146b, miR-181b, miR-221, miR-222, miR-21, and miR-146b expressions in MDA-MB-231 cells, by passing 24 and 48h from treating with the extract of E. microsciadia.Results:The results reveal the cytotoxic effects of E. microsciadia on MDA-MB-231 cell line in a dose-dependent manner. The half maximal Inhibitory Concentrations (IC50) were also equal to 275 and 240μg/ml for E. microsciadia, by passing 24 and 48h from the treatment, respectively. Furthermore, it was confirmed that, E. microsciadia had augmented the expression levels of Let-7, miR-15, miR-16, miR-29, and miR-34a, which lead to an increase in apoptosis.Conclusion:E. microsciadia could modulate some miRNAs involved in cell cycle arrest and apoptosis in MDA-MB-231 cell line. Accordingly, targeting miRNAs by E. microsciadia can open some newer avenues for breast cancer therapy.
Antihyperglycemic Potential of Matricaria pubescens (Desf.) Schultz. in Streptozotocin-induced Diabetic Rats
Authors: Amssayef Ayoub , Ajebli Mohammed , Eddouks Mohamed 
Published: June 2020

Aims:
The study aimed to investigate the antihyperglycemic activity of Matricaria
pubescens.

Background:
Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for
the treatment of diabetes in Morocco.

Objective:
The present investigation aimed to assess the antihyperglycemic and antioxidant effects
of the aqueous extract of the aerial part of Matricaria pubescens (M. pubescens).

Methods:
The effect of a single and repeated oral administration of the aqueous extract of aerial
part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and
streptozotocin-induced diabetic rats. Additionally, histopathological examination of the pancreas
and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was
performed using the DPPH assay.

Results:
The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant
lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition,
AEAPMP ameliorated the histopathological tissues of the liver and pancreas. Furthermore, in vitro
antioxidant activity of AEAPMP has been shown.

Conclusion:
In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect
against hyperglycemia associated with diabetes.
Knowledge and Attitudes of Dental Interns and Dentists on Implants and Implant-Retained Restorations in Jeddah, Saudi Arabia
Authors: Alghamdi Maryam , Aboalshamat Khalid , Alghamdi Doaa , Abed Shroug , Almahlawi Halah , AlKathiri Sereen , Abu Thiraa Amal , Alsulami Afaf , Alzughaibi Maha 
Published: June 2020

Objectives:
This cross-sectional study aimed to assess the knowledge and attitudes of dental interns and dentists in Jeddah, Saudi Arabia, about Cement-Retained Restoration (CRR), Screw Retained Restoration (SRR), and implant restoration.

Methods:
A total of 530 dentists and students participated in the study. Data were collected using a self-administrated questionnaire modified from previous studies. The collected data were analyzed using SPSS software for t-test, linear regression, and ANOVA.

Results:
Participants had a mean score of 5.01 (SD = 1.50) for a total of nine implant-retained restoration (IRR)knowledge questions (lowest score = 0, highest score = 9), and general implant knowledge had a mean score of 3.12 (SD = 1.25) for five questions with scores of 0 to 5. The participants’ knowledge about implants significantly differed in relation to gender, place of work, and work status. Also, participant knowledge about IRR showed significant differences in relation to participants' knowledge, age, gender and place of work. The dental interns and dentists were in agreement in considering SRR to be better than CRR for six out of nine factors. Those factors were cost effectiveness, expertise required for provision, retrievability, retention, fracture resistance, and passivity of fit.

Conclusion:
The overall knowledge of dental interns and dentists regarding implants and IRR was fair and needs to be improved, given the tendency of general dentists to engage in implant dentistry. Both dentists and interns considered CRR to be aesthetically superior, easier to fabricate, and requiring comparatively less expertise in comparison to SRR.
Anti-neuropathic Pain Effects of Ethyl Acetate Extract of Ferula asafoetidaOleo-Gum-Resin in Streptozotocin-induced Diabetic Rats
Authors: Nazemi Samad , Rudsarabi Hamid , Amin Bahareh , Farahani Hamid , Zarmehri Hasan Azhdari , Mojadadi Mohammad-Shafi 
Published: June 2020

Objective:
Diabetic Neuropathic Pain (DNP) is a common complication in both types of
diabetes, which does not respond well to common pain medications. Asafoetida, an oleo-gum-resin
extracted from Ferula asafoetida, is used as an analgesic, sedative, and antispasmodic in Iranian traditional
medicine. Hence, the present study aimed to investigate the anti-neuropathic pain effects of
asafoetida in streptozotocin-induced diabetic rats.

Methods:
Forty male Wistar rats were randomly divided into five groups. In four groups, diabetes
was induced by intraperitoneal injection of a single-dose of streptozotocin (60 mg/kg). Three diabetic
groups were treated once daily with asafoetida extract at doses 25, 50, and 100 mg/kg for 25 days.
In all groups, the neuropathic pain was evaluated using behavioral tail-flick and von-Frey tests on
days 0, 7, 14, 21, and 28. In addition, fasting blood glucose was also measured at the mentioned
days.

Key Findings:
According to the results obtained from the behavioral tests, neuropathic pain was established
in the diabetic rats on day 21. However, in comparison to untreated animals, the intensity
of the pain (thermal hyperalgesia and mechanical allodynia) was significantly lower in groups receiving
asafoetida extract (50 mg/kg, P<0.05 and 100 mg/kg, P<0.01). In addition, the extract could
decrease fasting blood glucose in a dose-dependent manner (P<0.05).

Conclusion:
Ethyl acetate extract of asafoetida can prevent the development of neuropathic pain in
diabetic rats. This effect may be, in part, due to the glucose lowering effect of asafoetida. However,
further studies are needed to determine the possible mechanisms of action in relieving DNP.
Conservative treatment of facial burns
Authors: Chmyrev I. V. , Butrin Ya. L. 
Published: June 2020

Objective: compare the effectiveness of using a moisturizer containing antibacterial drugs of plant origin with a water-soluble ointment that includes the antibiotic chloramphenicol in the treatment of victims with burns of the face II-IIIа degrees.Materials and methods: The results of treatment of 27 victims (12 men and 15 women) with burns of the face and other areas of the body of I – II degree with a total area of 1 to 6 % of the body surface at the age of 18 – 60 years were analyzed. In the main group (13 patients), a cream containing antibacterial drugs of plant origin was used. In the control group (14 patients), bandages with a water-soluble ointment containing an artificial synthesized antibiotic chloramphenicol were used. Visually evaluated the course of the wound process, the nature and volume of exudate, the healing time of burn wounds when using ointments. Seeding of the wound discharge was done on the day of admission, on the 5th and 10th day of treatment. The structure and number of microflora of burn wounds were studied.Results: in the third seeding of the main group, the concentration of bacteria was (2.4 ± 0.04) x103 CFU / g. in the third seeding of the control group, the concentration of microorganisms was (5.9 ± 0.03)×105 CFU / g. the duration of hospitalization in the main group was 18.1 ± 1.5 days, in the control group — 23.8 ± 1.9 days.Conclusions: cream containing antibacterial preparations of plant origin, in comparison with a water-soluble ointment that includes an artificial synthesized antibiotic chloramphenicol, reduces the bacterial contamination of wounds in victims with superficial burns of the face by 2×102 times, the duration of inpatient treatment for 5 days (p < 0.05).
The dynamics of the quality of life of primary schoolchildren with different cognitive success
Authors: Levchin A. M. , Lebedenko A. A. , Ershova I. B. , Glushko Ju. V. 
Published: June 2020

Objective: of the study was to study the quality of life of younger students in the dynamics of their education in primary school.Materials and methods: 573 children of primary schools of Rostov-on-Don were examined. Th e study of quality of life was carried out using the PedsQL 4.0 questionnaire. Depending on the level of cognitive development, children were divided into 2 groups: 82 children with high cognitive development made up the I (main) group and 491 children with an average level of cognitive development made up the II (control) group. Cognitive development was evaluated by the D. Wexler test, the Stanford-Binet intelligence scale with IQ coeffi cients, and E. Torrens creativity test.Results: primary schoolchildren with high cognitive abilities show a dynamic decrease in physical functioning with the lowest rates in the 4th grade, lower indicators of emotional functioning, characterized by an excessive reaction to failure, an increased level of anxiety and emotional instability. A decrease in social functioning is revealed, manifested by communicative problems in the process of interpersonal communication. Higher school functioning values were observed. From the 2nd grade, schoolchildren with high cognitive abilities showed statistically signifi cantly lower indicators of the overall quality of life score as compared with children of average intellectual development.Conclusions: among primary schoolchildren of high cognitive development, there is an imbalance in various aspects of the quality of life, which requires additional measures to optimize indicators.
Early detection of cognitive impairment in patients with hypertension and evaluation of treatment effectiveness according to EEG data
Authors: Nikolaenko M. V. , Kizhevatova E. A. , Drobotya N. V. 
Published: June 2020

Objective: to establish the relationship between the presence of cognitive disorders in patients with arterial hypertension and changes in EEG, to assess the dynamics of these changes against the background of various modes of cerebroprotective therapy.Materials and methods: the study involved 92 people with arterial hypertension, whose average age was 63 ± 8.2 years. The research was carried out on the device “Encephalan-EEGR-19/26”. To assess cognitive functions, patients were tested using the MoСA test. Patients with cognitive impairment were divided into three groups of dynamic monitoring with diff erent modes of cerebroprotective therapy.Results: non-specifi c patterns in the slow-wave range were registered in patients with cognitive impairment during visual EEG analysis. In the quantitative analysis of the EEG revealed changes in the frequency and amplitude of the alpha rhythm, the power variation on the basic rhythms, the reduction of the total strength of the rhythms, the increase in relative power of slow rhythms in the frontal leads to the total power of the rhythms. After the treatment, most patients showed an increase in scores on the “Montreal scale”, a decrease in anxiety and depression on the” Hospital scale”, and an increase in the SF-36 index. Quantitative EEG analysis revealed positive dynamics comparable to the clinic and test data. The most favorable EEG dynamics was registered in groups of patients receiving neuroprotective and combined therapy.Conclusions: the results obtained indicate the diagnostic value of quantitative EEG analysis and the feasibility of adding drugs that improve the metabolism and blood supply to the brain to standard antihypertensive therapy.
Study of biofilms by V. cholerae strains on the surfaces of biotic and abiotic substrates using mass spectrometry
Authors: Poleeva M. V. , Chemisova O. S. , Menshikova E. A. , Sagakyants M. M. , Kurbatova E. M. 
Published: June 2020

Objective: identification and comparative study of protein spectra of Vibrio cholerae biofilms by MALDI-ToF mass spectrometry.Materials and methods: V. cholerae O1 strains isolated from different sources were studied. Methods: bacteriological, mass spectrometry.Results: mass spectrometric analysis showed that it was impossible to identify strains from “plankton” samples and from chitin and plastic plates. After culturing the biofilm and plankton strains, all of them were assigned to the V. cholerae species with a Score above 2,300. A сomparative analysis of MALDI-ToF mass spectra of different variants of V. cholera cultures revealed differences, while general peaks with different intensity were maintained.Conclusions: all samples of V. cholerae cultures taken for analysis aft er culture on a nutrient medium were reliably identified with a high Score. As a result of comparative analysis of protein mass spectra by the m/z value and relative intensity of peaks, no proteins characteristic only for plankton cultures or biofilms of V. cholerae were detected. The stability of the phenotypic properties of V. cholerae regardless of its form of existence and the high reliability of the MALDI-ToF mass spectrometry method for identifying both planktonic and biofilm forms of V. cholerae with the preservation of the research protocol and bacteriological culturation.
Desarrollo de la mancha foliar por Bipolaris maydis (teleomorfo: Cochliobolus heterostrophus) en maíz dulce, en función de nitrógeno, potasio y silicio en invernadero
Authors: Castellanos González Leonides , De Mello Prado Renato , Silva Campos Cid Naudi , Barbosa da Silva Júnior Fiallos Gabriel 
Published: June 2020

El objetivo del trabajo fue evaluar el desarrollo de la mancha foliar causada por Bipolaris maydis, enfermedad común e n maíz dulce, según la dosis y el acumulado de nitrógeno, potasio y silicio, en condiciones de invernadero. Los tratamientos consistieron en cinco dosis de nitrógeno (N) (0, 200, 400, 800 y 1.200 kg/ha), aplicación o no de potasio (K) (240 kg/ha) y aplicación o no de silicio (Si) (380 kg/ha). Se empleó un diseño experimental completamente aleatorizado con esquema factorial 5 x 2 x 2 y tres repeticiones. Se inocularon todos los tratamientos a los 30 días con una suspensión de 2 x 105 conidios por mL de B. maydis. A los 42 días se midió la acumulación de N, K y Si, así como el porcentaje de infección y el área bajo la curva de progreso de la enfermedad (ABCPE). Los tratamientos que recibieron fertilización con Si y K presentaron mayores acumulados de N, K y Si, y niveles más bajos de intensidad de ataque y ABCPE. Los acumulados de N, K y Si presentaron variaciones frente a las interacciones de la fertilización de K con N, y de Si con N; sin embargo, los niveles de las variables de la enfermedad fueron menores en la fertilización con K o Si, combinadas con las dosis de 0, 200 y 400 kg/ha de N.
LEAVES (optimizing the mentaL health and resiliencE of older Adults that haVe lost thEir spouSe via blended, online therapy): Proposal for an Online Service Development and Evaluation
Authors: van Velsen Lex , Cabrita Miriam , op den Akker Harm , Brandl Lena , Isaac Joana , Suárez María , Gouveia Afonso , Dinis de Sousa Rute , Rodrigues Ana Maria , Canhão Helena , Evans Nathaniel ,   DELA Natura- En Levensverzekeringen NV, Blok Marije , Alcobia Carlos , Brodbeck Jeannette 
Published: June 2020

Background
Loss of a spouse is a frequent occurrence in later life. While most older adults successfully process this loss and will return to a normal life, about 10% of the individuals are unable to cope, and progress to prolonged grief (PG). PG, in turn, can result in mental and physical problems including poor sleep, cardiovascular problems, depression, and suicidal tendencies.

Objective
LEAVES (optimizing the mentaL health and resiliencE of older Adults that haVe lost thEir spouSe via blended, online therapy) is an online bereavement program that will support the prevention and treatment of PG, so that elderly mourners can continue to lead an active, meaningful, and dignified life. LEAVES will cater to secondary end users (eg, family, informal caregivers) by reducing stress.

Methods
LEAVES will help older adults to process the loss of a spouse in an online environment, which consists of (1) an existing online grief self-help program LIVIA, (2) the Before You Leave program that allows for storing personal memories, (3) a virtual agent platform, and (4) an accessible front-end design. LEAVES can detect persons at risk for complications, reveal negative trends in their emotional life, and act to counter such trends. The service relies on online support whenever possible but is blended with telephone or face-to-face counseling when necessary.

Results
The project will take place between February 2020 and January 2023 and includes a real-life evaluation in which 315 end users will use the service across 3 countries (the Netherlands, Portugal, and Switzerland). The evaluation of LEAVES will focus on clinical effect, its business case, and technology acceptance. The results will pave the way for smooth integration into existing care paths and reimbursement schemes.

Conclusions
The LEAVES service aims to soften the mourning process, prevents depression or social isolation, strengthens widow(er)s resilience and well-being, and quickens one’s return to societal participation.

International Registered Report Identifier (IRRID)
DERR1-10.2196/19344
Transdiagnostic Risk and Protective Factors for Psychopathology in Young People: Systematic Review Protocol
Authors: Lynch Samantha Jane , Sunderland Matthew , Newton Nicola Claire , Chapman Cath 
Published: June 2020

Background
Mental and substance use disorders are among the leading causes of burden of disease worldwide, with risk of onset peaking between the ages of 13 and 24 years. Comorbidity is also common among young people and complicates research, diagnosis and assessment, and clinical decision making. There is increasing support for empirically derived models of psychopathology that overcome issues of comorbidity and provide a transdiagnostic framework for investigating the specificity and generality of risk and protective factors for psychopathology.

Objective
This systematic review aims to identify transdiagnostic risk and protective factors for psychopathology in young people by synthesizing and evaluating findings from research investigating empirically based models of psychopathology.

Methods
Searches will be conducted in Medline, EMBASE, and PsycINFO databases. Reference lists of selected articles will also be hand searched for other relevant publications. All studies will be screened against eligibility criteria designed to identify studies that examined empirical models of psychopathology in relation to risk and/or protective factors in young people with a mean age between 10 and 24 years. Study quality will be assessed using the Joanna Briggs Institute Critical Appraisal Checklists for Cohort Studies and Analytical Cross-Sectional Studies. Findings will be summarized in a narrative synthesis, and a meta-analysis will be conducted if sufficient data are available.

Results
This review is ongoing. At the time of submission, full-text screening was completed, and hand searching of selected articles was underway. Results are expected to be completed by the end of 2020.

Conclusions
This protocol is for a systematic review of evidence for transdiagnostic risk and protective factors associated with empirically based models of psychopathology in young people. To our knowledge, the critical synthesis of this evidence will be the first to date and will provide a better understanding of the factors that contribute to the onset and maintenance of psychopathology in young people. Insights drawn from the review will provide critical new knowledge to improve the targeting of interventions to prevent or reduce mental health problems.

Trial Registration
This systematic review is registered with PROSPERO (CRD42020161368) and is available via Open Science Framework.

International Registered Report Identifier (IRRID)
DERR1-10.2196/19779