bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Preferences and Incentives for Evidence Acquisition and Disclosure
Authors: Giffin Erin , Lillethun Erik 
Published: January 2020

Abstract
Civil disputes feature parties with biased incentives acquiring evidence with costly effort. Evidence may then be revealed at trial or concealed to persuade a judge or jury. Using a persuasion game, we examine how a litigant’s risk preferences influence evidence acquisition incentives. We find that high risk aversion depresses equilibrium evidence acquisition. We then study the problem of designing legal rules to balance good decision making against the costs of acquisition. We characterize the optimal design, which differs from equilibrium decision rules. Notably, for very risk-averse litigants, the design is “over-incentivized” with stronger rewards and punishments than in equilibrium. We find similar results for various common legal rules, including admissibility of evidence and maximum awards. These results have implications for how rules could differentiate between high risk aversion types (e.g., individuals) and low risk aversion types (e.g., corporations) to improve evidence acquisition efficiency.
Refugee-Integration-Opportunity Structures: Shifting the Focus From Refugees to Context
Authors: Phillimore Jenny 
Published: January 2020

Abstract
Whilst it is increasingly acknowledged that integration is ‘a dynamic, two-way process of mutual accommodation by all immigrants and residents’, the focus in integration theory, policy and practice has been placed upon refugees or migrants themselves. The role of receiving societies in supporting and providing the context for integration has not been systematically interrogated. This article is original in its focus upon the role of receiving societies in shaping refugee-integration outcomes. It attends to multiple interconnecting receiving-society-opportunity structures shifting thinking about refugee integration by asking how refugee-receiving countries influence refugee integration. Introducing five sets of host society opportunity structures: locality, discourse, relations, structure and initiatives and support, the article highlights the impossibility of understanding integration outcomes using the unidimensional models that have largely dominated thinking to date. Instead, a multi-dimensional integration model is proposed that will allow more nuanced understanding of integration processes and how they occur at different levels. The article ends by outlining some ideas around how migration scholars shift their focus from refugee characteristics to understanding better the influence of host society opportunity structures.
Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation
Authors: Liu Kun-Hsiang , Diener Andrew , Lin Ziwei , Liu Cong , Sheen Jen 
Published: January 2020

Abstract
Nitrate, the major source of inorganic nitrogen for plants, is a critical signal controlling nutrient transport and assimilation and adaptive growth responses throughout the plant. Understanding how plants perceive nitrate and how this perception is transduced into responses that optimize growth are important for the rational improvement of crop productivity and for mitigating pollution from the use of fertilizers. This review highlights recent findings that reveal key roles of cytosolic–nuclear calcium signalling and dynamic protein phosphorylation via diverse mechanisms in the primary nitrate response (PNR). Nitrate-triggered calcium signatures as well as the critical functions of subgroup III calcium-sensor protein kinases, a specific protein phosphatase 2C, and RNA polymerase II C-terminal domain phosphatase-like 3 are discussed. Moreover, genome-wide meta-analysis of nitrate-regulated genes encoding candidate protein kinases and phosphatases for modulating critical phosphorylation events in the PNR are elaborated. We also consider how phosphoproteomics approaches can contribute to the identification of putative regulatory protein kinases in the PNR. Exploring and integrating experimental strategies, new methodologies, and comprehensive datasets will further advance our understanding of the molecular and cellular mechanisms underlying the complex regulatory processes in the PNR.
Imaging unlabeled proteins on DNA with super-resolution
Authors: Meijering Anna E C , Biebricher Andreas S , Sitters Gerrit , Brouwer Ineke , Peterman Erwin J G , Wuite Gijs J L , Heller Iddo 
Published: January 2020

Abstract
Fluorescence microscopy is invaluable to a range of biomolecular analysis approaches. The required labeling of proteins of interest, however, can be challenging and potentially perturb biomolecular functionality as well as cause imaging artefacts and photo bleaching issues. Here, we introduce inverse (super-resolution) imaging of unlabeled proteins bound to DNA. In this new method, we use DNA-binding fluorophores that transiently label bare DNA but not protein-bound DNA. In addition to demonstrating diffraction-limited inverse imaging, we show that inverse Binding-Activated Localization Microscopy or ‘iBALM’ can resolve biomolecular features smaller than the diffraction limit. The current detection limit is estimated to lie at features between 5 and 15 nm in size. Although the current image-acquisition times preclude super-resolving fast dynamics, we show that diffraction-limited inverse imaging can reveal molecular mobility at ∼0.2 s temporal resolution and that the method works both with DNA-intercalating and non-intercalating dyes. Our experiments show that such inverse imaging approaches are valuable additions to the single-molecule toolkit that relieve potential limitations posed by labeling.
Host and body site-specific adaptation of Lactobacillus crispatus genomes
Authors: Pan Meichen , Hidalgo-Cantabrana Claudio , Barrangou Rodolphe 
Published: January 2020

Abstract
Lactobacillus crispatus is a common inhabitant of both healthy poultry gut and human vaginal tract, and the absence of this species has been associated with a higher risk of developing infectious diseases. In this study, we analyzed 105 L. crispatus genomes isolated from a variety of ecological niches, including the human vaginal tract, human gut, chicken gut and turkey gut, to shed light on the genetic and functional features that drive evolution and adaptation of this important species. We performed in silico analyses to identify the pan and core genomes of L. crispatus, and to reveal the genomic differences and similarities associated with their origins of isolation. Our results demonstrated that, although a significant portion of the genomic content is conserved, human and poultry L. crispatus isolates evolved to encompass different genomic features (e.g. carbohydrate usage, CRISPR–Cas immune systems, prophage occurrence) in order to thrive in different environmental niches. We also observed that chicken and turkey L. crispatus isolates can be differentiated based on their genomic information, suggesting significant differences may exist between these two poultry gut niches. These results provide insights into host and niche-specific adaptation patterns in species of human and animal importance.
Bayesian correlation is a robust gene similarity measure for single-cell RNA-seq data
Authors: Sanchez-Taltavull Daniel , Perkins Theodore J , Dommann Noelle , Melin Nicolas , Keogh Adrian , Candinas Daniel , Stroka Deborah , Beldi Guido 
Published: January 2020

AbstractAssessing similarity is highly important for bioinformatics algorithms to determine correlations between biological information. A common problem is that similarity can appear by chance, particularly for low expressed entities. This is especially relevant in single-cell RNA-seq (scRNA-seq) data because read counts are much lower compared to bulk RNA-seq. Recently, a Bayesian correlation scheme that assigns low similarity to genes that have low confidence expression estimates has been proposed to assess similarity for bulk RNA-seq. Our goal is to extend the properties of the Bayesian correlation in scRNA-seq data by considering three ways to compute similarity. First, we compute the similarity of pairs of genes over all cells. Second, we identify specific cell populations and compute the correlation in those populations. Third, we compute the similarity of pairs of genes over all clusters, by considering the total mRNA expression. We demonstrate that Bayesian correlations are more reproducible than Pearson correlations. Compared to Pearson correlations, Bayesian correlations have a smaller dependence on the number of input cells. We show that the Bayesian correlation algorithm assigns high similarity values to genes with a biological relevance in a specific population. We conclude that Bayesian correlation is a robust similarity measure in scRNA-seq data.
How Financial Incentives Increase Smoking Cessation: A Two-Level Path Analysis
Authors: van den Brand Floor A , Candel Math J J M , Nagelhout Gera E , Winkens Bjorn , van Schayck Constant P 
Published: January 2020

AbstractIntroductionFinancial incentives effectively increase smoking cessation rates, but it is unclear via which psychological mechanisms incentives influence quit behavior. The current study examines how receiving financial incentives for smoking cessation leads to quitting smoking and investigates several mediators and moderators of that relationship.Aims and MethodsThe study sample consisted of 604 tobacco-smoking employees from 61 companies in the Netherlands who completed a baseline and follow-up questionnaire. The current study is a secondary analysis from a cluster randomized trial where employees received smoking cessation group counseling at the workplace. Participants in the intervention group additionally received financial incentives of €350 in total for 12-month continuous smoking abstinence. We used a two-level path analysis to test a model that assesses the effects of financial incentives through smoking cessation program evaluation, medication use, nicotine replacement use, attitudes, self-efficacy, and social influences on quit success. We additionally tested whether an individual’s reward responsiveness moderated the influence of incentives on quit success.ResultsThe effect of financial incentives on quit success was mediated by a higher self-efficacy. Financial incentives were also associated with a higher use of cessation medication. A more positive program evaluation was related to higher self-efficacy, more social influence to quit, and more positive attitudes about quitting. The results did not differ significantly by individual reward responsiveness.ConclusionsThe results of the current study suggest that financial incentives may be used to increase medication use and self-efficacy for quitting smoking, which offers an indirect way to increase successful smoking cessation.Implications(1) This is the first study investigating via which psychological pathways financial incentives for quitting smoking can lead to long-term quit success. (2) The results showed a path between financial incentives and a higher likelihood of medication use. Incentives may encourage smokers to use medication in order to increase their chance of quitting smoking and receive the reward. (3) There was a path from financial incentives to quit success via a higher self-efficacy. (4) The effects of financial incentives did not depend on individual reward responsiveness.
An individualized mental health education programme for Japanese managers
Authors: Soeda S 
Published: January 2020

Abstract

Background
Mental health education for managers has typically been conducted using a group format. Few studies have examined the provision of individualized education.

Aims
This study discussed the evaluations and characteristic needs of participants in an individualized mental health education programme while examining avenues for providing such education.

Methods
Eighty-nine individualized education sessions were conducted for managers (87 males, 2 females) with a mean age of 42.6 years (SD = 5.1) at an assembly factory in Japan. Data from anonymous self-administered questionnaires completed before and after the education programme were analysed.

Results
Overall, 95% of the managers (81/85) approved the individualized education format. The characteristic needs of participants with high motivation (45%, 38/85) were mental health consultations for managers (37%, 14/38, 95% confidence interval [CI] 1.62–14.7, P &lt; 0.01) and subordinate-related concerns (18%, 7/38, 95% CI 1.11–22.8, P &lt; 0.05).

Conclusions
Individualized education may be a suitable method for conducting mental health consultations. It is recommended that the introduction of individualized education formats be implemented through voluntary consultations following group education. Individualized education may contribute to early intervention for work-related mental disorders.
Male and Female Genital Cutting: Between the Best Interest of the Child and Genital Mutilation
Authors: Möller Kai 
Published: January 2020

Abstract
In the UK, male genital cutting is in principle legal and may even be ordered by a court, whereas female genital cutting is a criminal offence. The coherence of this approach was recently questioned by Munby P in Re B and G (children) (No 2); the present article continues this inquiry and demonstrates that the justifications that the courts have provided for the differential treatment of male and female cutting—relating to the harm involved in the respective practices, possible medical benefits of male cutting, the absence of a religious motivation with regard to female cutting, and patriarchal power structures enabling female but not male cutting—are insufficient. It proposes a different foundation for the categorical rejection of female genital cutting and argues that such practices are wrong as a matter of principle. This provides a convincing basis for the rejection of all forms of female genital cutting, including comparatively mild ones such as ritual nicks, and furthermore leads to the conclusion that male cutting, too, must be regarded as categorically impermissible.
Enthesitis in psoriatic arthritis (Part 2): imaging
Authors: Kaeley Gurjit S 
Published: January 2020

AbstractEnthesitis is a hallmark finding in PsA and may predate the onset of synovitis. Clinical examination of enthesitis provides no structural information, relies on eliciting tenderness at entheseal sites and may not be sensitive or specific. Soft tissue imaging techniques such as musculoskeletal ultrasound and MRI can depict ultrastructural and inflammatory changes. Although these imaging techniques are complimentary, ultrasound can image superficial entheses with high fidelity and examine vascularity with the use of Doppler but cannot image subchondral bone. MRI depicts bone and can visualize bone marrow edema as well as soft tissue edema. However, due to short relaxation times, entheseal structures are not easily differentiated. There has been increasing recognition of biomechanical confounding, especially since the majority of the entheses examined are in the lower extremity. Imaging entheseal indices are being developed to minimize the effect of body weight and activity. In the following article, contemporary concepts of entheses in relation to imaging will be reviewed as well as important confounders in assessing entheseal alterations. The role and limitations of imaging techniques will be discussed.
Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample
Authors: Hirotsu Camila , Betta Monica , Bernardi Giulio , Marques-Vidal Pedro , Vollenweider Peter , Waeber Gérard , Pichot Vincent , Roche Frederic , Siclari Francesca , Haba-Rubio Jose , Heinzer Raphael 
Published: January 2020

Abstract

Study Objectives
To explore the clinical significance of pulse wave amplitude (PWA)-drops during sleep as a biomarker for cardiometabolic disorders and describe their main characteristics in a general population sample.

Methods
Cross-sectional study of HypnoLaus cohort, in which 2162 individuals underwent clinical assessment and in-home full polysomnography. PWA-drops were derived from photoplethysmography and processed using a validated automated algorithm. Associations between PWA-drop features (index, mean duration, and mean area under the curve [AUC]) with hypertension, diabetes, and previous cardiovascular (CV) event were analyzed using multivariable-adjusted logistic regression.

Results
Two thousand one hundred forty-nine participants (59 ± 11 years, 51% women, 9.9% diabetes, 41.3% hypertension, 4.4% CV event) were included. Mean ± standard deviation (SD) of PWA-drop index, duration, and AUC during sleep were 51.0 ± 20.3 events/hour, 14.0 ± 2.7 seconds, and 527±115 %seconds, respectively. PWA-drop index was lower in women and decreased with age, while its mean duration and AUC increased in men and elderly. Overall, lower PWA-drop index, longer duration and greater AUC were associated with increased odds of hypertension, diabetes, or CV event after adjustment for confounders. Participants in the lowest quartile of mean duration-normalized PWA-drop index had a significantly higher odds ratio (OR) of hypertension (OR = 1.60 [1.19–2.16]), CV event (OR = 3.26 [1.33–8.03]), and diabetes (OR = 1.71 [1.06–2.76]) compared to those in the highest quartile. Similar results were observed for mean AUC-normalized PWA-drop index regarding hypertension (OR = 1.59 [1.19–2.13]), CV event (OR = 2.45 [1.14–5.26]) and diabetes (OR = 1.76 [1.10–2.83]).

Conclusions
PWA-drop features during sleep seem to be an interesting biomarker independently associated with cardiometabolic outcomes in the general population.
Regulating Switzerland’s trust industry—the way ahead
Authors: de Vos Burchart Fabianne 
Published: January 2020

Abstract
As of 1 January 2020, trustees active on Swiss soil are subject to a new regulatory and supervisory framework, which shall gradually bring about profound changes within the industry, as trustees will be required, within the applicable transitional period, to comply with a number of financial, personal and organizational requirements. These changes will not only affect Swiss trustees but also foreign trustees with a presence in Switzerland.
CE: An Evidence-Based Update on Contraception
Authors: Britton Laura E. , Alspaugh Amy , Greene Madelyne Z. , McLemore Monica R. 
Published: January 2020

ABSTRACT:
Contraception is widely used in the United States, and nurses in all settings may encounter patients who are using or want to use contraceptives. Nurses may be called on to anticipate how family planning intersects with other health care services and provide patients with information based on the most current evidence. This article describes key characteristics of nonpermanent contraceptive methods, including mechanism of action, correct use, failure rates with perfect and typical use, contraindications, benefits, side effects, discontinuation procedures, and innovations in the field. We also discuss how contraceptive care is related to nursing ethics and health inequities.
Managing Urinary Incontinence
Authors: Davis Nicole J. , Wyman Jean F. 
Published: January 2020

This article is part of a series, Supporting Family Caregivers: No Longer Home Alone, published in collaboration with the AARP Public Policy Institute. Results of focus groups, conducted as part of the AARP Public Policy Institute's No Longer Home Alone video project, supported evidence that family caregivers aren't given the information they need to manage the complex care regimens of family members. This series of articles and accompanying videos aims to help nurses provide caregivers with the tools they need to manage their family member's health care at home.
The articles in this new installment of the series provide simple and useful instructions that nurses should reinforce with family caregivers. This article is the second of two that provide an update on urinary incontinence and its management in older adults. It includes an informational tear sheet—Information for Family Caregivers—that contains links to the instructional videos. To use this series, nurses should read the articles first, so they understand how best to help family caregivers, and then encourage caregivers to watch the videos and ask questions. For additional information, see Resources for Nurses.
Adopting a Global Virtual Team Approach to Enhance Performance of an International Nursing Research Collaboration
Authors: Bish Melanie , Stacey Gemma , Shatto Bobbi , Meyer Geralyn 
Published: January 2020

Abstract
Global mobility, technological developments, and evolved organizational design have expanded the scope of workplace teams beyond traditional arrangements, giving rise to global virtual teams. As universities across the world encourage mobility, there are unprecedented opportunities to create discipline-specific international networks, increase cross-cultural understanding, and create rich interactions in research. Team structure, trust formation, and communication processes are known to positively influence global virtual team performance. They are discussed to illustrate the value of a structured model of work in an international research-focused collaboration of nursing academics from the United States, the United Kingdom, and Australia.
Oral mite anaphylaxis: who, when, and how?
Authors: Sánchez-Borges Mario , Capriles-Hulett Arnaldo , Fernandez-Caldas Enrique 
Published: January 2020

Purpose of review
To present an update on the recent advances in the understanding of the mechanisms and practical management of oral mite anaphylaxis (OMA, pancake syndrome).

Recent findings
Among novel observations regarding OMA, this review highlights the increased prevalence of aspirin/NSAID hypersensitivity inpatients affected by OMA, the association of OMA with exercise-induced anaphylaxis, the presentation of OMA simulating acute asthma, the occurrence of OMA in childhood, the high severity and lethal potential of OMA, the contamination of other foods, such as oat and corn flour with mites, and the simultaneous induction of OMA symptoms in more than one individual exposed to the same food source.

Summary
OMA is a severe, potentially lethal, acute allergic condition that should be suspected whenever symptoms begin soon after the intake of mite-contaminated foods. Physician awareness on this clinical picture is of paramount importance to establish a correct diagnosis and to implement adequate preventive measures to help patients at risk to avoid its occurrence.