bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint effect of diabetes and opiate use on all-cause and cause-specific mortality: the Golestan cohort study
Authors: Nalini Mahdi , Khoshnia Masoud , Kamangar Farin , Sharafkhah Maryam , Poustchi Hossein , Pourshams Akram , Roshandel Gholamreza , Gharavi Samad , Zahedi Mahdi , Norouzi Alireza , Sotoudeh Masoud , Nikmanesh Arash , Brennan Paul , Boffetta Paolo , Dawsey Sanford M , Abnet Christian C , Malekzadeh Reza , Etemadi Arash 
Published: June 2020

AbstractBackgroundMany diabetic individuals use prescription and non-prescription opioids and opiates. We aimed to investigate the joint effect of diabetes and opiate use on all-cause and cause-specific mortality.MethodsGolestan Cohort study is a prospective population-based study in Iran. A total of 50 045 people—aged 40–75, 28 811 women, 8487 opiate users, 3548 diabetic patients—were followed during a median of 11.1 years, with over 99% success follow-up. Hazard ratio and 95% confidence intervals (HRs, 95% CIs), and preventable death attributable to each risk factor, were calculated.ResultsAfter 533 309 person-years, 7060 deaths occurred: 4178 (10.8%) of non-diabetic non-opiate users, 757 (25.3%) diabetic non-users, 1906 (24.0%) non-diabetic opiate users and 219 (39.8%) diabetic opiate users. Compared with non-diabetic non-users, HRs (95% CIs) for all-cause mortality were 2.17 (2.00–2.35) in diabetic non-opiate users, 1.63 (1.53–1.74) in non-diabetic opiate users and 2.76 (2.40–3.17) in diabetic opiate users. Among those who both had diabetes and used opiates, 63.8% (95% CI: 58.3%–68.5%) of all deaths were attributable to these risk factors, compared with 53.9% (95% CI: 50%–57.4%) in people who only had diabetes and 38.7% (95% CI: 34.6%–42.5%) in non-diabetic opiate users. Diabetes was more strongly associated with cardiovascular than cancer mortality. The risk of early mortality in known cases of diabetes did not depend on whether they started opiate use before or after their diagnosis.ConclusionsUsing opiates is detrimental to the health of diabetic patients. Public awareness about the health effects of opiates, and improvement of diabetes care especially among individuals with or at risk of opiate use, are necessary.
Clinical Trials of Broadly Neutralizing Monoclonal Antibodies for Human Immunodeficiency Virus Prevention: A Review
Authors: Mahomed Sharana , Garrett Nigel , Baxter Cheryl , Abdool Karim Quarraisha , Abdool Karim Salim S 
Published: June 2020

Abstract
Passive immunization with broadly neutralizing antibodies (bnAbs) is a promising approach to reduce the 1.7 million annual human immunodeficiency virus (HIV) infections globally. Early studies on bnAbs showed safety in humans, but short elimination half-lives and low potency and breadth. Since 2010, several new highly potent bnAbs have been assessed in clinical trials alone or in combination for HIV prevention. Published data indicate that these bnAbs are safe and have a half-life ranging from 15 to 71 days. Only intravenous VRC01 has advanced to an efficacy trial, with results expected in late 2020. If bnAbs are shown to be effective in preventing HIV infection, they could fast-track vaccine development as correlates of protection, and contribute as passive immunization to achieving the goal of epidemic control. The purpose of the current review is to describe the current status and provide a synopsis of the available data on bnAbs in clinical trials for HIV prevention.
China’s ‘Coercive Tourism’: motives, methods and consequences
Authors: Paradise James F 
Published: June 2020

Abstract
This article considers 13 instances in which China has used tourist sanctions as an instrument of its foreign policy. It finds that the effectiveness of those sanctions has been limited by target state considerations including the ability to diversify source markets, constraining effects of international alliances, and national security, sovereignty and territorial considerations, matters which are also of importance to China. The article highlights the ways in which the Chinese government regulates outbound travelers through directives, travel advisories, granting or denying countries Approved Destination Status and disseminating information through the state-owned media and indicates that social actors such as consumers and netizens play a role as well. It also investigates the goals of China’s actions which usually have to do with protecting core interests broadly defined. Among the cases covered are ones involving Japan, the Philippines, Turkey, Taiwan, South Korea, the Vatican, Palau, North Korea, Australia, the United States, Canada, New Zealand and Sweden. Not covered are Belt and Road countries with whom China is practicing positive forms of tourist statecraft which may be more effective.
Electronic health records contain dispersed risk factor information that could be used to prevent breast and ovarian cancer
Authors: Payne Thomas H , Zhao Lue Ping , Le Calvin , Wilcox Peter , Yi Troy , Hinshaw Jesse , Hussey Duncan , Kostrinsky-Thomas Alex , Hale Malika , Brimm John , Hisama Fuki M 
Published: June 2020

Abstract

Objective
The genetic testing for hereditary breast cancer that is most helpful in high-risk women is underused. Our objective was to quantify the risk factors for heritable breast and ovarian cancer contained in the electronic health record (EHR), to determine how many women meet national guidelines for referral to a cancer genetics professional but have no record of a referral.

Methods and Materials
We reviewed EHR records of a random sample of women to determine the presence and location of risk-factor information meeting National Comprehensive Cancer Network (NCCN) guidelines for a further genetic risk evaluation for breast and/or ovarian cancer, and determine whether the women were referred for such an evaluation.

Results
A thorough review of the EHR records of 299 women revealed that 24 (8%) met the NCCN criteria for referral for a further genetic risk evaluation; of these, 12 (50%) had no referral to a medical genetics clinic.

Conclusions
Half of the women whose EHR records contain risk-factor information meeting the criteria for further genetic risk evaluation for heritable forms of breast and ovarian cancer were not referred.
Feeding Habits of Vector Mosquitoes in Harris County, TX, 2018
Authors: Mann James G , Washington Megan , Guynup Taylor , Tarrand Christopher , Dewey Elizabeth M , Fredregill Chris , Duguma Dagne , Pitts R Jason 
Published: June 2020

Abstract
Mosquito-borne pathogens contribute significantly to the global burden of infectious diseases and are a continuing public health concern in the United States. Blood feeding by vector mosquitoes is a critical step in the transmission of human pathogens. Continuous surveillance of mosquito feeding patterns, especially in major population centers, is necessary for sustainable, effective control strategies. To better understand female feeding habits in Harris County, TX, we trapped mosquitoes from various locations, distributed among urban and semi-urban environments. Bloodmeal hosts were determined using a cytochrome C oxidase I DNA barcoding strategy. We identified a diverse array of vertebrate hosts with a high degree of avian host utilization, most surprisingly from anthropophilic species like Aedes aegypti (L.). We also detected sequences from two different vertebrate hosts in about half of specimens examined, suggesting that multiple bloodmeals had been acquired in the same feeding cycle by a sizable fraction of females in both urban and semi-urban locations. The high proportion of feeding on domestic chickens may indicate that a significant number of homeowners are rearing chickens within close proximity to study trap sites. As non-amplifying hosts, chickens may have a diluting effect on West Nile virus, as well as a zooprophylactic effect in their immediate vicinities. Ultimately, spatial and temporal host utilization patterns add insight into potential disease transmission dynamics, thereby informing vector control strategies in Harris County and other metropolitan areas.
SEM-EDX and FTIR analysis of archaeological ceramic potteries from southern Italy
Authors: Dey Tania , Carter Joseph Coleman , Swift Keith 
Published: June 2020

AbstractSherds of ancient ceramics potteries, dating back to the seventh century BC and excavated from southern Italy, were analyzed in terms of microstructure and porosity (SEM), elemental composition (EDX), chemical bonding and mineralogical components (FTIR) in order to establish correlation with firing temperature, firing condition and provenance. Si/Al ratio from EDX analysis showed three major categories of raw materials (illite/montmorillonite, kaolinite and mullite), suggesting difference in provenance. Uniformly sized silica nanoparticle (0.7 μm diameter) and trace amount of silver are being reported for the first time in one sample. Anorthite mineral and quartz inclusion was detected by FTIR in certain samples. All samples showed a prominent band for Si-O stretching, which shifted from 1062 cm−1, broadened and appeared as doublet, relative to processing temperature. FTIR results proved incomplete dihydroxylation and undissociated carbonate in three samples, indicating a firing temperature of 700–800°C, whereas other samples were fired above 900°C. Only one sample among these three showed bloating pores in between interconnecting glassy matrix in SEM image, indicating a firing temperature of 1100–1200°C. The absence of magnetite along with significant Fe and Mn content indicated the formation of jacobsite, an iron manganese spinel complex, MnFe2O4, which is responsible for the black gloss effect in two particular samples and can be further confirmed by XRD. The presence of numerous small pores in SEM image of one of these two samples (1.2 μm diameter) was indicative of extended vitrification at higher temperature than the other one. However, magnetite was responsible for black gloss effect in two other samples, proving difference in provenance. Therefore, SEM-EDX and FTIR results can offer valuable insight into the firing conditions, gloss decoration and provenance of ancient ceramic potteries.
Using Contextual and Visual Cues to Improve Sung Word Recognition in Hearing Aid Users
Authors: Wilhelm Lindsey A 
Published: June 2020

AbstractOlder adults commonly experience hearing loss that negatively affects the quality of life and creates barriers to effective therapeutic interactions as well as music listening. Music therapists have the potential to address some needs of older adults, but the effectiveness of music interventions is dependent on the perception of spoken and musical stimuli. Nonauditory information, such as contextual (e.g., keywords, picture related to song) and visual cues (e.g., clear view of singer’s face), can improve speech perception. The purpose of this study was to examine the benefit of contextual and visual cues on sung word recognition in the presence of guitar accompaniment. The researcher tested 24 community-dwelling older adult hearing aid (HA) users recruited through a university HA clinic and laboratory under 3 study conditions: (a) auditory stimuli only, (b) auditory stimuli with contextual cues, and (c) auditory stimuli with visual cues. Both visual and contextual nonauditory cues benefited participants on sung word recognition. Participants’ music background and training were predictive of success without nonauditory cues, and visual cues provided greater benefit than contextual cues. Based on the results of this study, it is recommended that music therapists increase the accessibility of music interventions reliant upon lyric recognition through the incorporation of clear visual and contextual cues.
Germination strategies under climate change scenarios along an aridity gradient
Authors: Zogas Alexander , Kosman Evsey , Sternberg Marcelo 
Published: June 2020

Abstract

Aims
Climate change in the eastern Mediterranean region will have a strong impact on ecosystem functioning and plant community dynamics due to a reduction in annual rainfall and increased variability. We aim to understand the role of seed banks as potential buffers against climatic uncertainty determined by climate change.

Methods
We examined germination strategies of 18 common species present along an aridity gradient. Data were obtained from soil seed banks germinated during nine consecutive years from arid, semi-arid, Mediterranean and mesic Mediterranean ecosystems. At the semi-arid and Mediterranean sites, rainfall manipulations simulating 30% drought and 30% rainfall increase were applied. Germination strategies were tested under optimal irrigation conditions during three consecutive germination seasons to determine overall seed germinability in each soil sample. Changes in germination strategy were examined using a novel statistical approach that considers the climatic and biotic factors that may affect seed germinability.

Important Findings
The results showed that dominant species controlled their germination fractions by producing seeds with a different yearly germination fraction probability. The amount of rainfall under which the seeds were produced led to two major seed types with respect to germinability: high germinability, seeds leading to transient seed banks, and low germinability, seeds leading to persistent seed banks. We conclude that differential seed production among wet and dry years of both seed types creates a stable balance along the aridity gradient, enabling the soil seed bank to serve as a stabilizing mechanism buffering against rainfall unpredictability. Additionally, we present a general model of germination strategies of dominant annual species in Mediterranean and arid ecosystems that strengthens the notion of soil seed banks as buffers against climatic uncertainty induced by climate change in the region.
Linking plant spatial aggregation with reproductive traits and near-source seed dispersal: ecological adaptation to heavy grazing
Authors: Liu Wenting , Sun Shixian , Zhang Chunping , Lv Shijie , Dong Quanmin 
Published: June 2020

AbstractAimsEcological strategies related to the adaptation of plants to environmental stress have long been studied by ecologists, but few studies have systematically revealed the ecological process of plant adaptation to herbivores as a whole.MethodsIn this study, Stipa breviflora, the dominant species in the desert steppe of Inner Mongolia, was used to analyse its reproductive individual characteristics and seed traits as well as the soil seed bank and spatial patterns under heavy-grazing and no-grazing treatments.Important FindingsThe results showed that the number of reproductive branches positively affected the number of vegetative branches. The analysis of the soil seed bank showed that the density of S. breviflora seeds beneath reproductive S. breviflora individuals was significantly higher than that in bare land. The seed density was also significantly negatively correlated with the seed characteristics and the soil seed bank in bare land. The spatial distribution of S. breviflora was aggregated under heavy grazing. Our results suggest that under heavy grazing, reproductive activity plays a key role in resource allocation. Stipa breviflora evolved the ecological strategy of nearby diffusion by regulating the morphological characteristics of the seeds, which promotes a positive spatial correlation between the juvenile and adult populations at a small scale, thus leading to the formation of ‘safe islands’.
Risk of Repeated Admissions for Respiratory Syncytial Virus in a Cohort of &gt;10 000 Hospitalized Children
Authors: Wong Kerry , Robinson Joan L , Hawkes Michael T 
Published: June 2020

Abstract

Background
The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections.

Methods
This was a retrospective database analysis. The Alberta Health Services Discharge Abstract Database was searched for patients &lt;5 years of age admitted to any hospital with a primary diagnosis of RSV from July 1, 2004 through June 30, 2017. Clinical characteristics were compared for children with repeat RSV admission during the same RSV season (but &gt;30 days apart so presumably due to separate infections) compared with all other children with RSV admissions.

Results
During the study period, 10 212 children had 10 967 RSV admissions. The RSV hospitalization rate was 1.6%. A total of 666 children (6.5%) were readmitted for RSV at least once during the study period, of whom 433 (4.2%) were readmitted within 30 days of the initial hospital discharge. There were 36 children (0.35%) with 2 RSV admissions &gt;30 days apart during the same RSV season. When compared to all other children with RSV admissions, they were more likely to have congenital heart disease or to have been diagnosed with RSV pneumonia (vs bronchiolitis or upper respiratory tract infection) during their initial hospitalization.

Conclusions
The RSV hospitalization rate in children &lt;5 years of age was 1.6%. Repeat RSV infections requiring readmission during the same RSV season occurred following only 0.35% of RSV hospitalizations.
Pararenal aortic aneurysm in situs inversus totalis: open repair with right retroperitoneal approach
Authors: Gatta Emanuele , Schiavon Sara , Pagliariccio Gabriele , Persechini Perla , Carbonari Luciano 
Published: June 2020

Abstract
Situs inversus totalis (SIT) refers to a mirror-image reversal of the internal organ position. The coexistence of abdominal aortic aneurysm and SIT is extremely rare; very short series have been reported; therefore its prevalence has never been estimated. The presence of anatomical anomalies could increase operative risk. The authors describe a case of successfully repaired pararenal abdominal aortic aneurysm with a right retroperitoneal approach in situs inversus totalis.
Biomass composition explains fruit relative growth rate and discriminates climacteric from non-climacteric species
Authors: Roch Léa , Prigent Sylvain , Klose Holger , Cakpo Coffi-Belmys , Beauvoit Bertrand , Deborde Catherine , Fouillen Laetitia , van Delft Pierre , Jacob Daniel , Usadel Björn , Dai Zhanwu , Génard Michel , Vercambre Gilles , Colombié Sophie , Moing Annick , Gibon Yves 
Published: June 2020

AbstractFleshy fruits are very varied, whether in terms of their composition, physiology, or rate and duration of growth. To understand the mechanisms that link metabolism to phenotypes, which would help the targeting of breeding strategies, we compared eight fleshy fruit species during development and ripening. Three herbaceous (eggplant, pepper, and cucumber), three tree (apple, peach, and clementine) and two vine (kiwifruit and grape) species were selected for their diversity. Fruit fresh weight and biomass composition, including the major soluble and insoluble components, were determined throughout fruit development and ripening. Best-fitting models of fruit weight were used to estimate relative growth rate (RGR), which was significantly correlated with several biomass components, especially protein content (R=84), stearate (R=0.72), palmitate (R=0.72), and lignocerate (R=0.68). The strong link between biomass composition and RGR was further evidenced by generalized linear models that predicted RGR with R-values exceeding 0.9. Comparison of the fruit also showed that climacteric fruit (apple, peach, kiwifruit) contained more non-cellulosic cell-wall glucose and fucose, and more starch, than non-climacteric fruit. The rate of starch net accumulation was also higher in climacteric fruit. These results suggest that the way biomass is constructed has a major influence on performance, especially growth rate.
Influence of the Sun-like magnetic cycle on exoplanetary atmospheric escape
Authors: Hazra Gopal , Vidotto Aline A , D’Angelo Carolina Villarreal 
Published: June 2020

ABSTRACT
Stellar high-energy radiation (X-ray and extreme ultraviolet, XUV) drives atmospheric escape in close-in exoplanets. Given that stellar irradiation depends on the stellar magnetism and that stars have magnetic cycles, we investigate how cycles affect the evolution of exoplanetary atmospheric escape. First, we consider a hypothetical HD209458b-like planet orbiting the Sun. For that, we implement the observed solar XUV radiation available over one and a half solar cycles in a 1D hydrodynamic escape model of HD209458b. We find that atmospheric escape rates show a cyclic variation (from 7.6 to 18.5 × 1010 g s−1), almost proportional to the incident stellar radiation. To compare this with observations, we compute spectroscopic transits in two hydrogen lines. We find non-detectable cyclic variations in Ly α transits. Given the temperature sensitiveness of the H α line, its equivalent width has an amplitude of 1.9 mÅ variation over the cycle, which could be detectable in exoplanets such as HD209458b. We demonstrate that the XUV flux is linearly proportional to the magnetic flux during the solar cycle. Secondly, we apply this relation to derive the cyclic evolution of the XUV flux of HD189733 using the star’s available magnetic flux observations from Zeeman Doppler Imaging over nearly a decade. The XUV fluxes are then used to model escape in HD189733b, which shows escape rate varying from 2.8 to 6.5 × 1010 g s−1. Like in the HD209458b case, this introduces variations in Ly α and H α transits, with H α variations more likely to be observable. Finally, we show that a strong stellar flare would enhance significantly Ly α and H α transit depths.
Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response
Authors: Calls Aina , Torres-Espin Abel , Navarro Xavier , Yuste Victor J , Udina Esther , Bruna Jordi 
Published: June 2020

AbstractBackgroundCisplatin-induced peripheral neuropathy (CIPN) is a frequent serious dose-dependent adverse event that can determine dosage limitations for cancer treatment. CIPN severity correlates with the amount of platinum detected in sensory neurons of the dorsal root ganglia (DRG). However, the exact pathophysiology of CIPN is poorly understood, so the chance of developing neuroprotective treatment is reduced. The aim of this study was to determine the exact mechanisms involved in CIPN development.MethodsBy single-cell RNA-sequencing (scRNAseq), we have studied the transcriptomic profile of DRG sensory neurons from a well-characterized neurophysiological mouse model of CIPN.ResultsGene Ontology analysis of the scRNAseq data indicated that cisplatin treatment induces the upregulation of biological pathways related to DNA damage response (DDR) in the DRG neuronal population. Moreover, DRG neurons also upregulated the Cdkn1a gene, confirmed later by the measurement of its protein product p21. While apoptosis activation pathways were not observed in DRG sensory neurons of cisplatin-treated mice, these neurons did express several senescence hallmarks, including senescence-associated β-galactosidase, phospho-H2AX, and nuclear factor kappa B (Nfkb)–p65 proteins.ConclusionsIn this study, we determined that after cisplatin-induced DNA damage, p21 appears as the most relevant downstream factor of the DDR in DRG sensory neurons in vivo, which survive in a nonfunctional senescence-like state.