bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major clades and a revised classification of Magnolia and Magnoliaceae based on whole plastid genome sequences via genome skimming
Authors: Wang Yu‐Bing , Liu Bin‐Bin , Nie Ze‐Long , Chen Hong‐Feng , Chen Fa‐Ju , Figlar Richard B. , Wen Jun 
Published: April 2020

AbstractWith more than 300 species, the Magnoliaceae family represents a major Magnoliid lineage that is disjunctly distributed in Asia and the New World. The classification of Magnolia s.l. has been highly controversial among taxonomists, varying from one genus with several subgenera, sections, and subsections to several (up to 16) genera. We conducted a comprehensive phylogenetic study of Magnoliaceae on the basis of sequences of the complete chloroplast genomes with a broad taxon sampling of 86 species. The phylogenetic analyses strongly support 15 major clades within Magnolia s.l. due to the non‐monophyly of subgen. Magnolia, the previous subgeneric treatment that recognizes three subgenera, is not supported. Based on the phylogenetic, morphological, and geographic evidence, we recognize two subfamilies in Magnoliaceae: Liriodendroideae and Magnolioideae, each with one genus, Liriodendron and Magnolia, respectively. Magnolia is herein classified into 15 sections: sects. Magnolia, Manglietia, Michelia, Gwillimia, Gynopodium, Kmeria, Maingola, Oyama, Rytidospermum, Splendentes, Talauma, Tuliparia, Macrophylla, Tulipastrum, and Yulania.
HBcrAg and pg RNA and the therapeutic effect in HBeAg‐positive patients receiving anti‐viral therapy, baseline serum HBV‐RNA is a powerful predictor of response
Authors: Ma Guanghua , Lou Bin , Lv Feifei , Zhao Dejian , Zhang Zhe , Chen Yu 
Published: April 2020

AbstractWe used HBV core antigen (HbcrAg), pre‐genomic RNA (pg RNA) and other biomarkers to evaluate the therapeutic effect in HBV infected patients receiving anti‐viral therapy. 127HBeAg‐positive patients were enrolled: 35 patients received nucleotide therapy, 14 patients received interferon and 78 patients received combination therapy with both. HBcrAg, pg RNA and other biomarkers were detected at different time points, we defined the decreased titre of HBcrAg and HBeAg from baseline to 6 and baseline to 12 months as ∆HBcrAg and ∆HBeAg, which were used to predict HBeAg seroconversion. Furthermore, we used the time‐dependent receiver operator curve of different markers to analyse HBeAg seroconversion. For HBeAg seroconversion: at 6 months, 0.75 log10 U/mL of ∆HBcrAg and 1.47 log10PEI U/mL of ∆HBeAg showed maximum predictive value in receiver operator curve analysis (Youden's index values for area under the curve of 0.687 and 0.646, respectively). At 12 months, 2.05 log10 U/mL of ∆HBcrAg and 1.92 log10PEI U/mL of ∆HBeAg showed improved prediction (maximum Youden's index values, with areas under the curve of 0.688 and 0.698, respectively).pg RNA was a better predictor of outcome due and the concentrations of 6.20 log10I U/mL of pg RNA and 8.0 log10 U/mL of HBcrAg were cut‐off values for response in a Kaplan‐Meier curve analysis. Our results may be used to identify the pg RNA concentration in patients at baseline and ∆HBcrAg during therapy who are likely to achieve HBeAg seroconversion according to the cut‐off value at different time points, thus helping to evaluate the therapeutic effect.
Hyperthyroidism is not a risk factor for subclinical bacteriuria in cats: A prospective cohort study
Authors: Peterson Mark E. , Li Alice , Soboroff Peter , Bilbrough Graham E. , Rishniw Mark 
Published: April 2020

AbstractBackgroundSubclinical bacteriuria is defined as a positive bacterial urine culture in the absence of clinical evidence of urinary tract infection (UTI). Studies have reported that hyperthyroid cats have UTIs (mostly subclinical) with prevalence rates of 12%‐22%. Consequently, clinicians consider hyperthyroidism a risk factor for development of subclinical bacteriuria, and many recommend urine culture when evaluating hyperthyroid cats.ObjectivesTo compare the prevalence of subclinical bacteriuria (based on positive urine culture) in untreated hyperthyroid cats to that in euthyroid cats of similar age and sex.AnimalsThree hundred and ninety‐three hyperthyroid cats presented for radioiodine treatment and 131 euthyroid cats (≥7 years of age) presented for routine examination. Cats with signs of lower urinary tract disease were excluded.MethodsProspective cohort study. Both hyperthyroid and euthyroid cats had urine collected by cystocentesis for complete urinalysis and culture. Data pertaining to age, sex, body condition, and serum thyroxine and creatinine concentrations also were acquired. Logistic regression was performed to evaluate for potential risk factors for subclinical bacteriuria.ResultsHyperthyroid cats showed a low prevalence of subclinical bacteriuria (4.3%), which did not differ from that found in euthyroid cats (4.6%). Of the signalment factors evaluated, only female sex was a significant risk factor (odds ratio [OR], 6.9; P = .002). Furthermore, positive urine cultures were more likely in specimens with dilute urine concentration (<1.035), pyuria, or microscopic bacteriuria.Conclusions and Clinical ImportanceHyperthyroid cats are not at risk for subclinical bacteriuria. In the absence of lower urinary tract signs, no clinical benefit exists in routinely performing urine cultures when evaluating hyperthyroid cats.
Preconception helminth infection alters offspring microbiota and immune subsets in a mouse model
Authors: Nyangahu Donald D. , Darby Matthew , Havyarimana Enock , Brown Bryan P. , Horsnell William , Jaspan Heather B. 
Published: April 2020

AbstractBoth maternal microbiota and helminth infection may alter offspring immunity but the relationship between these is underexplored. We hypothesized that maternal helminth exposure prior to pregnancy has lasting consequences on offspring intestinal microbiota and consequent immunity. Female BALB/c adult mice were infected with 500L3 Nippostrongylus brasiliensis (N brasiliensis). Infection was cleared by ivermectin treatment, and mice were mated 3 weeks post‐infection (NbM). Control mice were not infected but were exposed to ivermectin (NvM). We analysed maternal gut microbiota during pregnancy, breastmilk microbiota and offspring faecal microbiota and immunity 2 weeks after delivery. During pregnancy, NbM (Mothers previously infected with Nippostrongylus brasiliensis) displayed significantly altered stool bacterial communities (R2 = .242; P = .001), with increased abundance of Enterococcaceae versus NvM (Naive mothers). Similarly, we observed a profound impact on breastmilk microbiota in NbM vs NvM. Moreover, NbM pups showed significantly altered gut microbial communities at 14 days of age versus those born to NvM with increased relative abundance of Coriobacteriaceae and Micrococcaceae. These changes were associated with alterations in pup immunity including increased frequencies and numbers of activated CD4 T cells (CD4 + CD44hi) in NbM offspring spleens. Taken together, we show that preconception helminth infections impact offspring immunity possibly through alteration of maternal and offspring microbiota.
When end‐stage kidney disease complicates abdominal surgery
Authors: Lew Susie Q. , Collins Ashté 
Published: April 2020

AbstractPatients receiving peritoneal dialysis (PD) encounter an increased risk for infection, bleeding, and PD fluid leakage after abdominal surgery. These complications may affect the future use of PD. Appropriate patient preparation may mitigate complications. Certain complications or procedures allow patients to remain on PD while others require transition to hemodialysis. We review the etiology and management of infection, bleeding, and PD fluid leakage associated with abdominal surgery as well as the relationship of specific abdominal procedures to continuing PD.
New trends in biochar pyrolysis and modification strategies: feedstock, pyrolysis conditions, sustainability concerns and implications for soil amendment
Authors: Wang Liuwei , Ok Yong Sik , Tsang Daniel C. W. , Alessi Daniel S. , Rinklebe Jörg , Wang Hailong , Mašek Ondřej , Hou Renjie , O'Connor David , Hou Deyi 
Published: April 2020

AbstractAs a waste‐derived soil amendment with a long history, biochar has received extensive attention for its capability to improve soil fertility/health; remove or immobilize contaminants in soil, water and air; and mitigate climate change. With the aim of producing engineered biochars with excellent performances, new trends in biochar pyrolytic production and modification strategies have emerged. This review critically summarizes novel pyrolysis methods (e.g., microwave‐assisted pyrolysis, co‐pyrolysis and wet pyrolysis) and modification approaches (e.g., mineral modification, photocatalytic modification, electrochemical modification) with a focus on (a) the mechanisms involved in environmental remediation processes including soil immobilization, contaminant adsorption and catalytic oxidation; (b) effects of feedstock and pyrolysis conditions on physicochemical properties; (c) sustainability considerations in novel modification and pyrolysis strategies; and (d) the feasibility of extrapolating the results from wastewater treatment to soil remediation. It is argued that in order to achieve the maximum net environmental benefits, ‘greener’ modification methods are warranted, and the risks associated with pyrolysis of contaminated feedstock in soil amendment and contaminant sorption can be minimized through various novel approaches (e.g., co‐pyrolysis). Furthermore, novel pyrolysis methods can be combined with emerging modification strategies to synthesize more ‘effective’ biochars. Considering the similar aims of modification (e.g., increase surface area, introduce oxygen‐containing functional groups, increase aromaticity), the applicability of several novel approaches could in future can be expanded from contaminant adsorption/degradation in aqueous media to soil remediation/fertility improvement.
Microbiologically documented infections after adult allogeneic hematopoietic cell transplantation: A 5‐year analysis within the Swiss Transplant Cohort study
Authors: Vu Diem‐Lan , Dayer Julie‐Anne , Masouridi‐Levrat Stavroula , Combescure Christophe , Boely Elsa , Khanna Nina , Mueller Nicolas J. , Kleber Martina , Medinger Michael , Halter JOERG , Passweg Jakob , Müller Antonia M. , Schanz Urs , Chalandon Yves , Neofytos Dionysios , van Delden Christian , Kaiser Laurent ,   Swiss Transplant Cohort Study
Published: April 2020

AbstractBackgroundInfections are an important complication after allogeneic hematopoietic cell transplantation (allo‐HCT). The present study aimed at determining the landscape of infections occurring in a large cohort of allo‐HCT patients, as well as associated risk factors for infections and for one‐year non‐relapse mortality.MethodsThis is a retrospective cohort study using STCS and EBMT databases to assess the one‐year incidence rate of infection, as well as risk factors for infections and for one‐year non‐relapse mortality among adult allo‐HCT patients transplanted between 2010 and 2014 in Switzerland. Univariable and multivariable quasi‐Poisson and multivariable Cox regression models were used.ResultsOf 553 patients included, 486 had an infection with a global incidence rate of 3.66 infections per patient‐year. Among a total of 1534 infections analyzed, viral infections were predominant (n = 1138, 74.2%), followed by bacterial (n = 343, 22.4%) and fungal (n = 53, 3.5%) infections. At one year, the cumulative incidence of relapse and non‐relapse mortality was 26% and 16%, respectively. 195 (35.3%) of patients had at least one episode of severe graft‐versus‐host‐disease (GvHD). A center effect was observed, and underlying disease, donor type, cytomegalovirus serological constellation, and GvHD were also associated with the incidence rate of infections. There was an increased risk for one‐year non‐relapse mortality associated with all pathogens, specifically within two months of infection, and this remained true beyond 2 months of a fungal infection.ConclusionDespite advances to limit infections in this population, they still occur in most allo‐HCT patients with a major impact on survival at 1 year.
Pneumocystis jiroveciiand toxoplasmosis prophylaxis strategies among pediatric organ transplantation recipients: A US National Survey
Authors: Hanisch Benjamin , Sprott Kathleen , Ardura Monica I. 
Published: April 2020

AbstractThere is a paucity of pediatric‐specific data to guide consensus recommendations for the prevention ofPneumocystis jiroveciipneumonia (PCP) and toxoplasmosis after solid organ transplantation. We surveyed pediatric transplantation providers and found considerable variability in prophylaxis strategies, despite current guideline recommendations that are based primarily on adult data.
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis)
Authors: Overcash J. Scott , Tiffany Courtney A. , Scangarella-Oman Nicole E. , Perry Caroline R. , Tao Yu , Hossain Mohammad , Barth Aline , Dumont Etienne F. 
Published: April 2020

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (
n
= 22) were confined to the clinic at baseline, received oral gepotidacin at 1,500 mg twice daily for 5 days (on-therapy period; days 1 to 5), and returned to the clinic for test-of-cure (days 10 to 13) and follow-up (day 28 ± 3) visits.
Voice and Power: Ḥafṣah bint al-Ḥājj and the Poetics of Women in Al-Andalus
Authors: Al-Mallah Majd 
Published: April 2020

Abstract
This paper examines the poetry of the Andalusī woman poet Ḥafṣah bint al-Ḥājj (d. 589/1191) in the context of a rich body of anecdotes surrounding that poetry as preserved in Nafḥ al-ṭīb, which al-Maqqarī (d. 1041/1632) wrote to preserve the cultural memory of al-Andalus. Known as the preeminent woman poet of Granada in the twelfth century, she lived most of her life under Almohad rule and had a connection to their court. Although literature surrounding Ḥafṣah is generally limited compared to major male poets, this paper will show that a close analysis of al-Maqqarī’s section on Ḥafṣah reveals the poet’s voice and agency. This paper argues that al-Maqqarī’s framing of Ḥafṣah in his landmark work elevates rather than marginalizes the poet and her status as a cultural figure in al-Andalus.
Pre-suppression Jesuit Activity in the British Isles and Ireland
Authors: McCoog Thomas M. 
Published: April 2020

Abstract
The British Isles and Ireland tested the self-proclaimed adaptability and flexibility of the new Society of Jesus. A mission to Ireland highlighted the complexities and ended in failure in the early 1580s, not to be revived until 1598. The fabled Jesuit mission to England in 1580 conceived in wistful optimism was baptized with blood with the execution of Edmund Campion in 1581 and the consequent political manoeuvres of Robert Persons. The Scottish mission began in December 1581. The three missions remained distinct in the pre-suppression period despite an occasional proposal for integration. The English mission was the largest, the bloodiest, the most controversial, and the only one to progress to full provincial status. The government tried to suppress it; the Benedictines tried to complement it; the vicars apostolic tried to control it; and foreign Jesuits tried to recognize it. Nonetheless, the English province forged a corporate identity that even withstood the suppression.
A simple equation to correct for gadolinium interference on plasma selenium measurement using inductively coupled plasma mass spectrometry
Authors: Wilschefski Scott , Baxter Matthew , Pool Gertruida 
Published: April 2020

Background The measurement of selenium in human plasma is useful to assess deficiency or toxicity. The presence of gadolinium in clinical samples following administration of certain contrast agents used for magnetic resonance imaging can cause a significant positive bias in selenium results when measured using quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS). Methods A mathematical equation to correct for gadolinium interference was assessed using both patient samples and commercial quality control/external quality assurance (QC/EQA) materials spiked with gadolinium. Samples were analysed using an Agilent 7900 ICP-MS operated in ‘narrow peak’ (half-mass) mode. Accuracy was evaluated by comparing corrected selenium results with target concentrations. Results Corrected results were found to be accurate at all gadolinium concentrations tested (2, 4, 10 and 20 mg/L). Average recoveries ranged from 97.4 to 106.5%. Results for QC/EQA materials were within specified target ranges. Within-run imprecision was <3%, and between-run imprecision was <4.3%, demonstrating robustness. Conclusions The correction equation described here is a simple method to correct for gadolinium interference on plasma selenium measurement using ICP-MS. This approach eliminates the need for specimen recollections, and improves patient care by reducing laboratory turnaround times and preventing delays in diagnosis/treatment.
Bailout bypass surgery for complications of coronary interventions
Authors: Szczechowicz Marcin P. , Mkalaluh Sabreen , Torabi Saeed , Zhigalov Konstantin , Mashhour Ahmed , Karck Matthias , Easo Jerry , Weymann Alexander 
Published: April 2020

Background Mechanical complications of percutaneous coronary interventions are treated percutaneously in most cases. If the rescue intervention is unsuccessful, bailout bypass surgery is necessary to restore the coronary flow. The surgical risk in these cases is higher than that of patients operated on for other indications. The aim of our study was to characterize patients who underwent surgical treatment at our institution and to compare their long-term outcomes with patients who underwent emergency bypass surgery for other indications. Methods We analyzed 707 consecutive patients who underwent isolated emergency bypass surgery at our institution from 2007 to 2015. In 44 of these cases, the surgery was necessitated by mechanical complications of percutaneous coronary interventions. There were 31 coronary dissections, 5 entrapped guidewires, and 8 coronary perforations. We compared patients in these three groups with one another. Follow-up was performed to assess long-term outcomes. Results The median age of the cohort was 68 years (range 59–75 years), and 36 (81.8%) patients presented in cardiogenic shock. Thirty-seven (84.1%) patients had history of a percutaneous coronary intervention. The courses were typical for bypass patients. The long-term survival was similar in all three subgroups ( p = 0.16). The survival profiles within our sample did not differ significantly from that in patients who underwent emergency bypass surgery for other indications. Conclusions Surgical risk and short- and long-term outcomes of patients undergoing emergency bypass surgery due to mechanical complications of percutaneous coronary interventions are similar to those of patients receiving the same surgery for other indications.
MR-guided focused ultrasound application for moving target tumor ablation in abdominal area: coil selection
Authors: Mihcin Senay , Gagliardo Cesare , Toia Patrizia , Dennison Andrew , Strehlow Jan , Melzer Andreas 
Published: April 2020

Background Magnetic Resonance Imaging (MRI)-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive thermal ablation method utilizing high-intensity focused ultrasound (HI-FU) energy for tissue ablation under MRI with real-time thermal mapping. Ablating to a dynamic target as in the liver is very challenging, requiring approval. A novel quality-assured liver tumor ablation system has been proposed for clinics. The paper reports the evaluation of conventional and new MR-receiving coils. Purpose To evaluate the suitability of MR coils as part of the MRgFUS treatment system for liver, while simulating breathing motion in pre-clinical settings. Material and Methods The novel software communicates with the MR scanner and the transducer. To monitor the temperature via proton resonance frequency (PRF) methodology echo planar imaging (EPI) sequence was used while the algorithms of static, static and dynamic tracking were tested with sonications of 100 W for 30 s on tissue-mimicking phantoms. Different coil sets were used to assess the performance of the system for fitness for dynamic thermometry. Finally, in vivo experiments were performed over a porcine model. Results Single-loop four-channel Duoflex and Gem coils provided adequate signal-to-noise ratio and contrast with consistent thermal readings. Body array coils showed severe loss of signal in dynamic cases since the integration of tracking algorithm causes low efficiency. Conclusion Body array coils are unsuitable for MRgFUS of the liver due to signal loss. The dedicated coil set with a single loop around the FUS transducer combined with four-channel arrays might be the best option for liver treatment using dynamic MRgFUS applications.
Energy management education and occupation-related outcomes in adults with chronic diseases: A scoping review
Authors: Farragher Janine F , Jassal Sarbjit V , McEwen Sara , Polatajko Helene J 
Published: April 2020

Introduction Fatigue is a pervasive symptom of chronic disease that often interferes with occupational performance. Our objective was to describe what is known about energy management education and occupation-related outcomes in adults with chronic diseases. Methods Seven electronic databases were searched for relevant literature published before August 2019. Eligible articles were full-text, available in English, and studied energy management education in adults with a chronic disease. The first author assessed article eligibility with validation from a second reviewer, extracted characteristics of included studies, and described them using descriptive statistics. A narrative synthesis of findings was conducted for each chronic disease population. Results Forty-four studies addressed eight different chronic disease populations. The most common program delivery format was face-to-face in a group setting (42%), 39% of programs were informed by a learning theory, and their median cumulative length was 8 hours. Positive outcomes were associated with a specific, group-based energy management program in people with multiple sclerosis. The evidence on other energy management programs and in other chronic disease populations was more limited and inconclusive. Conclusions Further research is needed to understand the impact of energy management education in chronic disease populations beyond multiple sclerosis, and its impact on occupational performance.