bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the DECA criteria for allergic conjunctivitis severity and control
Authors: Sánchez-Hernández M. Cesárea , Navarro Ana M. , Colás Carlos , del Cuvillo Alfonso , Sastre Joaquín , Mullol Joaquim , Valero Antonio 
Published: October 2020

AbstractBackgroundAllergic conjunctivitis (AC) is usually associated to allergic rhinitis (AR), but the severity and control of ocular symptoms should be assessed independently to improve diagnosis and treatment. The criteria from the Spanish consensus document on allergic conjunctivitis (DECA) aimed to be used as a patient-reported instrument for AC management. Here we validate these criteria for classifying AC severity and defining its control following COSMIN guidelines recommendations.MethodsPatients with moderate or severe AR [reflective total nasal symptom score (rTNSS) score ≥ 8] and concomitant AC were recruited from hospitals in Spain. Patients were classified according to the severity of ocular symptoms as mild, moderate, or severe, and classified with respect to control as controlled and non-controlled, using the DECA criteria. To validate these criteria, comparisons with the validated modified allergic rhinitis and its impact on asthma (mARIA), reflective total ocular symptom score (rTOSS), rhinitis control assessment test (RCAT), ESPRINT-15 questionnaires, a conjunctival hyperemia scale and a visual analogue scale (VAS) for ocular symptoms were performed.ResultsA total of 128 patients participated in the validation. Mean age was 34.4 ± 12.1 years; 72.7% were women. The DECA criteria showed a good discriminant validity, reflecting a high capacity to differentiate between mild, moderate, and severe patients, and controlled from uncontrolled patients. A strong association between AC and AR was reflected in the comparison between the DECA and the mARIA criteria (p < 0.0001). The DECA criteria for severity and control presented satisfactory properties for longitudinal validity and responsiveness.ConclusionsValidation of the DECA criteria for severity and control of AC suggested that it can be useful in the evaluation of eye symptoms and follow-up of therapies.
Normalized solutions for a coupled fractional Schrödinger system in low dimensions
Authors: Li Meng , He Jinchun , Xu Haoyuan , Yang Meihua 
Published: October 2020

AbstractWe consider the following coupled fractional Schrödinger system: $$ \textstyle\begin{cases} (-\Delta )^{s}u+\lambda _{1}u=\mu _{1} \vert u \vert ^{2p-2}u+ \beta \vert v \vert ^{p} \vert u \vert ^{p-2}u, \\ (-\Delta )^{s}v+\lambda _{2}v=\mu _{2} \vert v \vert ^{2p-2}v+\beta \vert u \vert ^{p} \vert v \vert ^{p-2}v \end{cases}\displaystyle \quad \text{in } {\mathbb{R}^{N}}, $$

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A new fourth-order explicit group method in the solution of two-dimensional fractional Rayleigh–Stokes problem for a heated generalized second-grade fluid
Authors: Khan Muhammad Asim , Ali Norhashidah Hj. Mohd , Hamid Nur Nadiah Abd 
Published: October 2020

AbstractIn this article, a new explicit group iterative scheme is developed for the solution of two-dimensional fractional Rayleigh–Stokes problem for a heated generalized second-grade fluid. The proposed scheme is based on the high-order compact Crank–Nicolson finite difference method. The resulting scheme consists of three-level finite difference approximations. The stability and convergence of the proposed method are studied using the matrix energy method. Finally, some numerical examples are provided to show the accuracy of the proposed method.
Grazing trajectory statistics and visualization platform based on cloud GIS
Authors: Li Dong , Wang Chuanjian , Wang Qilei , Yan Tianying , Bing Wanlong , Wang Ju 
Published: October 2020

Abstract
It is very important for ranchers and grassland livestock management departments to master the information on the trajectory and feeding behavior of the herd timely and accurately. Therefore, this study developed a statistics and visualization platform for grazing trajectory. The platform was implemented by using the Web AppBuilder for ArcGIS framework and ArcGIS Online server. In particular, the trajectory processing service on the server was used to calculate walking speed, walking trajectory and feed intake of the herd in the platform. And these results were published to the ArcGIS Online server. The relevant information was analyzed and displayed by Web AppBuilder for ArcGIS calling the data on ArcGIS Online. Moreover, the paltform provided some visualization functions to support the visualization of user-defined analysis results. When users use the functions of spatial analysis (such as buffer analysis, finding hot pots analysis and interpolation point analysis), they can choose to analyze spatial data and related field information to conduct customized spatial data analysis. In a short, the platform realized the visualization functions of feed intake statistics, walking speed statistics, spatial analysis, line chart analysis and pie chart analysis of spatial data related attributes. It can provide technical support and data support for the relevant management departments to monitor grazing information and study the living habits of the herd.
Elevated atmospheric CO2 impact on carbon and nitrogen transformations and microbial community in replicated wetland
Authors: Jiang Dawei , Chen Lifei , Xia Nan , Norgbey Eyram , Koomson Desmond Ato , Darkwah Williams Kweku 
Published: October 2020

Abstract
Background
Elevated atmospheric CO2 has direct and indirect influences on ecosystem processes. The impact of elevated atmospheric CO2 concentration on carbon and nitrogen transformations, together with the microbial community, was evaluated with water hyacinth (Eichhornia crassipes) in an open-top chamber replicated wetland. The responses of nitrogen and carbon pools in water and wetland soil, and microbial community abundance were studied under ambient CO2 and elevated CO2 (ambient + 200 μL L−1).

Results
Total biomass for the whole plant under elevated CO2 increased by an average of 8% (p = 0.022). Wetlands, with water hyacinth, showed a significant increase in total carbon and total organic carbon in water by 7% (p = 0.001) and 21% (p = 0.001), respectively, under elevated CO2 compared to that of ambient CO2. Increase in dissolved carbon in water correlates with the presence of wetland plants since the water hyacinth can directly exchange CO2 from the atmosphere to water by the upper epidermis of leaves. Also, the enrichment CO2 showed an increase in total carbon and total organic carbon concentration in wetland soil by 3% (p = 0.344) and 6% (p = 0.008), respectively. The total nitrogen content in water increased by 26% (p = 0.0001), while total nitrogen in wetland soil pool under CO2 enrichment decreased by 9% (p = 0.011) due to increased soil microbial community abundance, extracted by phospholipid fatty acids, which was 25% larger in amount than that of the ambient treatment.

Conclusion
The study revealed that the elevated CO2 would affect the carbon and nitrogen transformations in wetland plant, water, and soil pool and increase soil microbial community abundance.
Generalization support environment for understanding ways to use English words
Authors: Kojiri Tomoko , Yamada Takushi 
Published: October 2020

AbstractWhen we translate Japanese sentence into English, sometimes several English words become the candidates. However, the usage situation of these candidate words is not the same. In order to choose appropriate words from them, we need to understand the usage situation for each candidate words. Usage situation of the words can be inferred by co-existing words in their example sentences. Co-existing words in example sentences are not always the same, so in order to understand usage situation, we need to generalize co-existing words from several example sentences. However, some of us who do not consciously generalize the co-existing words do not acquire the usage situation. This paper proposes the system which provides the environment where we can explicitly generalize co-existing words (keywords) in the example sentences to acquire the usage situation of the target words. This system also has a generalization support mechanism to provide concepts of words acquired through WordNet as hints. According to the experimental results, participants who used the system in learning English words reduced the number of incorrectly choosing the words and promoted to derive the own understanding of the usage situation.
Paramedics in pandemics: protecting the mental wellness of those behind enemy lines
Authors: Awais Shehar Bano , Martins Russell Seth , Khan Muhammad Shameel 
Published: October 2020

SummaryBesides a global health crisis, the COVID-19 pandemic has potential to have a severe and long-lasting psychological impact on frontline healthcare workers such as paramedics. It is imperative to shed light on these mental health issues and employ interventions to protect the mental wellness of this vulnerable group of healthcare workers.
Survival, Pathologic Response, and Genomics in CALGB 40601 (Alliance), a Neoadjuvant Phase III Trial of Paclitaxel-Trastuzumab With or Without Lapatinib in HER2-Positive Breast Cancer
Authors: Fernandez-Martinez Aranzazu , Krop Ian E. , Hillman David W. , Polley Mei-Yin , Parker Joel S. , Huebner Lucas , Hoadley Katherine A. , Shepherd Jonathan , Tolaney Sara , Henry N. Lynn , Dang Chau , Harris Lyndsay , Berry Donald , Hahn Olwen , Hudis Clifford , Winer Eric , Partridge Ann , Perou Charles M. , Carey Lisa A. 
Published: October 2020

PURPOSE CALGB 40601 assessed whether dual versus single human epidermal growth factor receptor 2 (HER2) –targeting drugs added to neoadjuvant chemotherapy increased pathologic complete response (pCR). Here, we report relapse-free survival (RFS), overall survival (OS), and gene expression signatures that predict pCR and survival. PATIENTS AND METHODS Three hundred five women with untreated stage II and III HER2-positive breast cancer were randomly assigned to receive weekly paclitaxel combined with trastuzumab plus lapatinib (THL), trastuzumab (TH), or lapatinib (TL). The primary end point was pCR, and secondary end points included RFS, OS, and gene expression analyses. mRNA sequencing was performed on 264 pretreatment samples. RESULTS One hundred eighteen patients were randomly allocated to THL, 120 to TH, and 67 to TL. At more than 7 years of follow-up, THL had significantly better RFS and OS than did TH (RFS hazard ratio, 0.32; 95% CI, 0.14 to 0.71; P = .005; OS hazard ratio, 0.34; 95% CI, 0.12 to 0.94; P = .037), with no difference between TH and TL. Of 688 previously described gene expression signatures, significant associations were found in 215 with pCR, 45 with RFS, and only 22 with both pCR and RFS (3.2%). Specifically, eight immune signatures were significantly correlated with a higher pCR rate and better RFS. Among patients with residual disease, the immunoglobulin G signature was an independent, good prognostic factor, whereas the HER2-enriched signature, which was associated with a higher pCR rate, showed a significantly shorter RFS. CONCLUSION In CALGB 40601, dual HER2-targeting resulted in significant RFS and OS benefits. Integration of intrinsic subtype and immune signatures allowed for the prediction of pCR and RFS, both overall and within the residual disease group. These approaches may provide means for rational escalation and de-escalation treatment strategies in HER2-positive breast cancer.
Hypofractionated Prostate Radiation Therapy: Adoption and Dosimetric Adherence Through Clinical Pathways in an Integrated Oncology Network
Authors: Schad Michael D. , Patel Ankur K. , Ling Diane C. , Smith Ryan P. , Beriwal Sushil 
Published: October 2020

PURPOSE: Updates to consensus guidelines in October 2018 recommending moderately hypofractionated external beam radiotherapy (mHF-EBRT) in prostate cancer lagged several years after publication of evidence supporting its efficacy. In January 2018, we amended our prostate cancer clinical pathway (CP) to facilitate adoption of mHF-EBRT. Herein, we analyze patterns of care and changes in mHF-EBRT use after the CP modification. METHODS: Our prostate CP was amended in January 2018 to make mHF-EBRT the recommended treatment for patients with low- and intermediate-risk prostate cancer pursuing curative EBRT monotherapy. Normal-tissue dose constraints accompanied the CP modification to guide planning. Use of mHF-EBRT from 2015 to 2017 was compared with use in 2018 after the CP modification, using the Cochran-Armitage test for trend. Predictors of mHF-EBRT use and adherence to dose constraints were analyzed with binary logistic regression. RESULTS: In 560 patients treated with EBRT monotherapy, mHF-EBRT use increased from 3.7% in 2015-2017 to 85.6% in 2018 ( P < .001), whereas conventionally fractionated EBRT (CF-EBRT) use decreased from 96.3% to 14.4% ( P < .001). Consultation year of 2018 (odds ratio [OR], 214.6; 95% CI, 94.5 to 484.6; P < .001), treatment at an academic facility (OR, 4.5; 95% CI, 1.8 to 11.3; P = 0.001), and having a smaller prostate (OR, 0.99; 95% CI, 0.97 to 1.00; P = .028) predicted for mHF-EBRT use. At least five of six recommended bladder and rectal dose constraints were met in 89.4% of patients. CONCLUSION: Modification of our prostate cancer CP, in concert with institutional policies to monitor and audit CP compliance, facilitated rapid adoption of mHF-EBRT in our large, integrated cancer center with good adherence to dosimetric constraints.
Synthesis of Optically Active V-Shaped Molecules: Studies on the Orientation of the Stacked π-Electron Systems and their Chiroptical Properties
Authors: Miki Nanami , Inoue Ryo , Morisaki Yasuhiro 
Published: October 2020

Abstract
Chiral π-stacked molecules were prepared from planar chiral bis-(para)-pseudo-meta-type [2.2]paracyclophane. π-Electron systems were stacked to form a V-shaped structure with an angle of 120°. Optical and chiroptical properties were experimentally and theoretically investigated and compared with those of the V-shaped molecules comprising the same π-electron systems based on bis-(para)-pseudo-ortho-type [2.2]paracyclophane with an angle of 60°.
Use of High-fidelity simulation training for radiology healthcare professionals in the management of acute medical emergencies
Authors: Wheeler Matthew , Powell Eleanor , Pallmann Philip 
Published: October 2020

Objectives:
Life-threatening emergencies are relatively uncommon in the radiology department, but when encountered, require timely intervention. With an increasing number of critically unwell patients visiting the radiology department each year for both diagnostic and interventional procedures, it is vital that radiology staff are trained to provide basic resuscitation before further assistance arrives. Simulation training is a well-validated, effective method for rehearsing low-frequency, high-acuity events in a supportive and safe environment. The aim of our study was to investigate whether the introduction of a focussed, multidisciplinary simulation course would improve healthcare professional’s knowledge and confidence when managing common medical emergencies; including cardiac arrest, anaphylaxis and airway obstruction.

Methods:
A multidisciplinary group of radiology staff attended a dedicated simulation teaching course. Participants completed a pre- and post-test questionnaire which assessed a range of knowledge domains and their perceived confidence with dealing with the clinical scenarios. The delegates were then asked to repeat this questionnaire 6 months after taking part in the course to assess their retention of skills and knowledge.

Results:
Knowledge scores increased by a mean difference of 4 points (p &lt; 0.001). The mean pre- and post-course perceived confidence scores were 4.4/10 and 8/10, respectively.

Advances in knowledge:
This study suggests that embedding simulation training into the radiology curriculum improves healthcare professional’s knowledge and perceived confidence when dealing with common medical emergencies. Although previous studies have looked at the use of simulation training for radiology trainees in the management of selected medical emergencies, to the authors’ knowledge, this is the first study to demonstrate these benefits across a range of clinical scenarios, within an interprofessional environment.
Magnetic resonance image-guided adaptive stereotactic body radiotherapy for prostate cancer: preliminary results of outcome and toxicity
Authors: Ugurluer Gamze , Atalar Banu , Zoto Mustafayev Teuta , Gungor Gorkem , Aydin Gokhan , Sengoz Meric , Abacioglu Ufuk , Tuna Mustafa Bilal , Kural Ali Riza , Ozyar Enis 
Published: October 2020

Objective:
Using moderate or ultra-hypofractionation, which is also known as stereotactic body radiotherapy (SBRT) for treatment of localized prostate cancer patients has been increased. We present our preliminary results on the clinical utilization of MRI-guided adaptive radiotherapy (MRgRT) for prostate cancer patients with the workflow, dosimetric parameters, toxicities and prostate-specific antigen (PSA) response.

Methods:
50 prostate cancer patients treated with ultra-hypofractionation were included in the study. Treatment was performed with intensity-modulated radiation therapy (step and shoot) technique and daily plan adaptation using MRgRT. The SBRT consisted of 36.25 Gy in 5 fractions with a 7.25 Gy fraction size. The time for workflow steps was documented. Patients were followed for the acute and late toxicities and PSA response.

Results:
The median follow-up for our cohort was 10 months (range between 3 and 29 months). The median age was 73.5 years (range between 50 and 84 years). MRgRT was well tolerated by all patients. Acute genitourinary (GU) toxicity rate of Grade 1 and Grade 2 was 28 and 36%, respectively. Only 6% of patients had acute Grade 1 gastrointestinal (GI) toxicity and there was no Grade ≥ 2 GI toxicity. To date, late Grade 1 GU toxicity was experienced by 24% of patients, 2% of patients experienced Grade 2 GU toxicity and 6% of patients reported Grade 2 GI toxicity. Due to the short follow-up, PSA nadir has not been reached yet in our cohort.

Conclusion:
In conclusion, MRgRT represents a new method for delivering SBRT with markerless soft tissue visualization, online adaptive planning and real-time tracking. Our study suggests that ultra-hypofractionation has an acceptable acute and very low late toxicity profile.

Advances in knowledge:
MRgRT represents a new markerless method for delivering SBRT for localized prostate cancer providing online adaptive planning and real-time tracking and acute and late toxicity profile is acceptable.
Políticas migratórias brasileiras e Filosofia Política: questões biopolíticas | Brazilian migration policies and political philosophy: biopolitical questions
Authors: Cunha Pinto Anna Carolina , Borges Soares Marianna , Cunha Ribeiro Luís Antônio 
Published: October 2020

O presente artigo visa resgatar algumas especificidades relativas às políticas migratórias brasileiras, fazendo referência a diferentes conjunturas históricas e políticas. Debater-se-á a construção de um determinado “tipo” de migrante que se buscou atrair e, ao mesmo tempo, outro “tipo” que se buscou repelir do território brasileiro ao longo do tempo, através do poder institucional do Estado forjado pelas leis. Tais dispositivos serão analisados levando em conta seu caráter eugênico e securitizatório, à luz do conceito da biopolítica.Palavras-chave: políticas migratórias, biopolítica, controle social.Abstract:This article aims to introduce some particularities related to Brazilian migration policies, in different historical and political contexts. The construction of a specific “type” of migrant that the State intended to attract will be discussed as well as another “type” of migrant that was repelled from Brazilian territory over time. This was conducted through the institutional power of the State. The analysis will take into account their eugenic and securitization characteristics, in light of the concept of biopolitics.Keywords: migration policies, biopolitics, social control. Recebido em: 31 jan. 2019 | Aceito em: 18 out. 2020.
Numerical simulation of pillars and electromagnetic mode coupling for nanoparticle sensors
Authors: Bassène Pascal D. 
Published: October 2020

Sensors based on the response of the photonic crystal in imprint polymers (hydrogels) have recently attracted considerable attention for visual medical diagnostics, pharmaceutical bioassays, environmental monitoring, and nanoparticle detection. These applications often use the variation of the wavelength as a function of the diameter of the air sphere (inverse opal hydrogels) according to the Bragg equation at a fixed incident angle. However, these promising materials mixed with fluorescent nanocrystals for the detection of targeted nanoparticles have never been explored so far with the finite differential time-domain (FDTD) method, electric field intensity map, and radiated power profile at far-field. In this paper, we have combined silicon nanopillars, nanoparticles, imprint polymers, and nanocrystal fluorescence. The sensitivity of the sensor we simulate depends on the nanocrystal fluorescence variation when the imprint polymer swells (polymer thickness variation). We have shown numerically that the electric field intensity at far-field is at a maximum in the pillar’s symmetrical axis when the dipole (representing the nanocrystal) polarization is perpendicular to the pillar. Also, we have shown that radiated power is increasing and monotone when the thickness of the imprint polymer evolves between 498 and 912 nm. The purpose of this numerical simulation is to develop a nanoparticle sensor with high sensitivity, high selectivity, and an efficient detection device.
The fanciful optimism of Miguel Sánchez-Mazas. Let us calculate... = Freedom and Justice
Authors: De Lorenzo Javier , Ibarra Andoni 
Published: October 2020

May 2020 marks the 25thanniversary of the death of Miguel Sánchez-Mazas, founder of Theoria - An International Journal of Theory, History and Foundations of Science and regarded as the person who brought mathematical logic to Spain. Here we present some of his biographical features, as well as a summary of his contributions, from his early work in the 1950s - introducing contemporary advances in logic and philosophy of science in a philosophically backward milieu dominated by the scholasticism of that era in Spain - to the development of a project of Lebnizian lineage aimed at producing an arithmetic calculation that would elude some of the difficulties confronting Leibniz's calculus.