bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Trade of Sago in Ambon, 1880-1900
Authors: Masyitah Putri Maya , Susilowati Endang , Tri Sulistiyono Singgih 
Published: December 2020

During the late 19th century, sago in Ambon turned out not only to be a subsistence crop used as a staple food, but also as a commercial crop. Historical sources shown that sago became one of the important commodities in trade in the 19th century, as one of the commodities that affected the economy of the Ambonese people and the colonial government. Sago became a prominent commodity when the spices trade decreased. So, there is commercialization process of sago as an important trade commodity. In this connection, this article examines several issues, the sago became a strategic commodity and the role of sago in the Ambonese economy during 1880-1900. It is analyzed by using the historical method, which emphasized on primary sources based on official reports in the form of colonial publications. According to the study, between 1880 -1900 it was known that the local community and colonial government traded the sago. One interesting thing is that aside from being a staple food, sago is also used as a currency that is bartered with other commodities that have the same value. For the colonial government, sago became a commercial commodity that was quite productive, even having become an export commodity to various countries, such as Singapore and Europe. The colonial government sold sago in various forms such as bundles, basketry, slabs, flour, and grains. In addition, the government also rents sago lands to Christians and Muslims merchants for a specified period and cost.
Association of SNP T125A on KiSS1 gene with reproduction hormone levels in Kaligesing goat
Authors: Hardyta G. , Widayati D.T. , Maharani D. 
Published: December 2020

The objective of this study was to assess the association of KiSS1 gene polymorphism with reproductive traits in Kaligesing goat. Genotypes of 48 ewes aged three years old were determined using PCR-RFLP and DNA sequencing. Sixteen out of 48 samples were monitored for the estrus cycle and determined their 17β-estradiol and progesterone levels using ELISA method. The results showed that KISS1 gene in the studied population was polymorphic with one single nucleotide polymorphism (SNP T125A). Then SNP was used to analyze genotype all individuals by PCR-RFLP method using MboII enzyme. Three genotypes (TT, TA and AA) were identified. Genotype frequencies of TA were 59.57%, AA were 40.43% while TT was not inculed in calculation for genetic diversity and assosication analysis since the number of genotype only one goat. The allele frequencies of T and A were 29.79% and 70.21%, respectively. The genotype distribution for the SNP was deviated from Hardy-Weinberg equilibrium (χ2=8.10; P<0.025). Hormonal analysis showed that the levels of 17β-estradiol in the follicular and luteal phase were 50.12±61.26 and 42.35±42.43 pg/ml, respectively, while the levels of progesterone hormone in the follicular and luteal phase were 7.87±10.59 and 12.39±15.93 ng/ml. No significant associations of the polymorphism were observed for any hormonal levels. However, it was first report about polymorfism in KiSS1 gene of local Indonesian goat especially Kaligesing goat.
Motility characterization of albumin sexed spermatozoa in two different diluents and additional antioxidant
Authors: Ratnawati D. , Luthfi M. , Pamungkas D. , Affandhy L. 
Published: December 2020

The purpose of this study was to characterize spermatozoa motility of sexed semen (X and Y) using albumin by diluents and antioxidant treatments. The material used in this study was fresh semen of Ongole Crossbreed (OC) bull with progressive motility >70%. The sperm sexing methodology used albumin gradient of 5%, 10%, and 15%. The diluents used were CEP-2 and andromed with or without the addition of 1mM Glutathione as an antioxidant. The sexed semen was made into liquid semen and stored at 3-5°C. The motility was observed at day 0 (H0) and day 5 (H5). Motility was analyzed using SCA v.2.1. The parameters measured were total motility, progressive motility, VCL, VSL, VAP, LIN, STR, WOB, ALH, BCF and sperm hyperactive. The experimental applied was the factorial pattern 2 x 2. The first factor was the type of diluents (CEP-2 and Andromed), and the second factor was additional glutathione (with or without). Data was analyzed by general linear model of SPSS-IBM 24 program. Sexed semen with CEP-2 diluents showed better motility of spermatozoa than andromed in the upper layers (spermatozoa X) and lower layers (spermatozoa Y). The CEP-2 diluent had a big role to maintain motility, progressive motility and velocity spermatozoa during cold storage. The addition of Glutathione 1mM could support the motility of sexed spermatozoa at cold storage, especially for LIN, STR, and WOB values.
Cultivo y crecimiento de trucha arco iris (Oncorhynchus mykiss) alimentada con dos marcas de alimento extruido: estudio en laguna altoandina de Perú
Authors: COELA MULLISACA EDWIN 
Published: December 2020

La trucha arco íris (Oncorhynchus mykiss) es la especie que se cultiva en diferentes cuerpos de agua de los andes del Perú, destacando la región Puno en la producción nacional. Dado al potencial que tiene y con el fin de optimizar su cultivo, el objetivo de esta investigación fue evaluar el crecimiento de la trucha cultivada en sistema de cultivo de jaulas flotantes utilizando alimentos de dos marcas diferentes. El estudio se efectuó en Lagunillas, cuerpo de agua ubicado en la región Puno. Se realizó un experimento que duró ocho meses. Se formaron dos lotes, el primer lote fue alimentado con productos Purina y el segundo con productos Naltech. Se efectuó el monitoreo mensual de la talla y peso de los peces cultivados y se observó el crecimiento en biomasa e individual. Del experimento se observó que los productos de la marca Purina permitieron alcanzar una biomasa de 6027.5 kg en el octavo mes, y de la marca Naltech 5230.0 kg. Obteniéndose mayor rendimiento en biomasa con el lote alimentado con productos Purina. Esta información es importante para que los productores de trucha tengan mejor criterio en la selección del alimento en su manejo productivo.
Pengembangan Bahan Ajar Model Pembelajaran Blended Learning Berbantuan Geogebra untuk Meningkatkan Kemampuan Berpikir Kritis Matematis Siswa SMA
Authors: Gusmawan Dendy Maulana , Priatna Nanang 
Published: December 2020

Pembelajaran matematika menggunakan model blended learning di sekolah menengah bukan lagi merupakan sebuah tuntutan tetapi sudah merupakan implikasi tidak langsung dari perkembangan teknologi. Maka dari itu, kajian tentang bagaimana pengembangan bahan ajar yang baik dalam penyusunan bahan ajar dengan model blended learning menjadi hal yang penting. Keberhasilan pembelajaran blended learning sangat bergantung pada kemandirian siswa dalam belajar, maka dari itu untuk menarik minat siswa belajar secara mandiri digunakan bantuan aplikasi GeoGebra. Tujuan dari kajian ini adalah mengetahui hal-hal yang perlu diperhatikan dalam penyusunan bahan ajar untuk siswa SMA yang menggunakan model pembelajaran blended learning untuk memfasilitasi pencapaian kemampuan berpikir kritis matematis siswa pada topik aplikasi turunan. Kajian ini berasal dari studi literatur dan penelitian-penelitian terdahulu, pemilihan submodel pembelajaran disesuaikan dengan keadaan di lapangan yang akan berimplikasi langsung pada pemilihan strategi pembelajaran.
Pengenalan Kebudayaan Indonesia melalui Fotografi pada Akun Instagram “KWODOKIJO”
Authors: Sari Maya Purnama , Hidayatulloh Ali Rahmat 
Published: December 2020

Kebudayaan merupakan identitas bangsa Indonesia, kekhasan serta keragamannya perlu ditanamkan, dicintai oleh warga Indonesia serta dapat diperkenalkan kepada seluruh dunia. Kemudahan teknologi saat ini mampu menjangkau genarasi muda yang ingin mengenal kebudayaan Indonesia dengan segala kemudahannya, salah satu teknologi hasil karya fotografi dapat menjadi fasilitas dalam mengenal kebudayaan Indonesia. Tujuan dari penelitian yaitu mengenal kebudayaan Indonesia dari unsur kebudayaan secara universal dari hasil karya fotografi akun Instagram “kwodokijo”. Metode penelitian menggunakan pendektaan kualitatif deskriptif dengan studi literatur hasil karya fotografi serta kebudayaan Indonesia. Hasil penelitian ini menunjukan bahwa dari ketujuh unusr kebudayaan secara iniversal, hasil karya kwodokijo hanya menunjukan enam unsur kebudayaan, yang tercipta secara lisan tidak terekam oleh fotografi. Sistem Bahasa. Seluruh hasil karya “kwodokijo” Sangat mencerminkan situasi dan kondisi kebudayaan asli Indonesia yang dapat menjadi identitas bangsa, dengan mudah dapat diakses oleh masyarakat local dan dunia dari berbagai kalangan.
The study of oropharyngeal pack soaked in lignocaine with dexamethasone in patients undergoing nasal surgeries
Authors: Agrawal Mahendra , Gandhi Pushpal , Agrawal Bhavika , Behl Simarn 
Published: December 2020

Background: The aim of this study determines the efficacy of lignocaine lignocaine with dexamethasone used topically in form of oropharyngeal pack in reducing postoperative sore throat (POST), hoarseness and throat irritation. Methods: This retrospective study total of 70 adult patients included in the lignocaine and dexamethasone (LD) group. LD group patients received combination of 5 ml lignocaine 2% and 2 ml (8 mg) dexamethasone in oropharyngeal packing.Results: There is no significant difference in age, gender, and American society of anesthesiologists (ASA) grade I and II. There was no significant difference the studied group in term of measured hemodynamic indices Systolic blood pressure, diastolic blood pressure, pulse rate, and respiratory rate. Post extubation incidence of mild sore throat was occurred in patients 11 (31.4%) at 30 min, 13 (37.1%) at 2 hours, 6 (17.1%) at 6 hours, and 5 (14.2%) at 5 (14.2%). Moderate sore throat and severe sore throat was not present. Hoarseness of voice was present only 4 (11.4%) at 30 min. There was significant deference in throat irritation. A decrease in incidence of hoarseness was also seen in group LD. Conclusions: In LD group a positive beneﬁt is seen in form of reduction of POST, hoarseness and throat irritation helping in better recovery of patients.
Existing and to be developed teacher competences in engineer teacher training
Authors: Harangus Katalin , Horváth Zsófia-Irén , Szentes Erzsébet 
Published: December 2020

Teacher competences are made up of abilities, skills and other knowledge and behaviours that teachers need to carry out well as a teacher. The effective establishment and development of these should therefore be a key objective of teacher training. In this paper, we present what engineering undergraduate students in teacher training consider to be the current and expected level of competencies they need to have in their teaching profession. The survey included students who already acquired professional methodology and knowledge during their training. The measurement instrument contained a list of competences, including key competences proposed by the European Council, as well as student competencies and knowledge that we consider essential for an engineering teacher. The results highlight the competences that need to be developed in teacher training so that students can meet professional expectations and challenges as a practicing teacher.

Keywords: Teaching competences, key competences, teacher training, engineering students.
Comparison of the Efficacy and Safety of Dexmedetomidine Administrated in two Different Modes in Sedative and Analgesic Anesthesia: A Randomized Controlled Trial
Authors: Xia Weipeng , Wei Lingxin , Deng Xiaoming , Yang Dong , Sui Jinghu , Sun Yulei , Liu Juhui , Wang Lei 
Published: December 2020

Abstract
Background: To observe and compare the efficacy and safety of dexmedetomidine administrated in two different modes in sedative and analgesic anesthesia. Methods: Sixty female patients, of American Society of Anesthesiologists physical status I or II, aged from 18-52 years and scheduled for elective plastic operations under sedative and analgesic anesthesia were randomly divided into a control group and an intervention group, with 30 patients in each group. All patients were administered IV midazolam 0.04mg/kg and a continuous infusion of 0.1 μg/kg/min of remifentanil at the beginning of anesthesia. Patients in the control group received IV dexmedetomidine (DEX) 1 μg/kg over 15 min followed by 0.4-0.7 μg/kg/h infusion while patients in the intervention group received IV DEX 1 μg/kg over 30 min followed by 0.4-0.7 μg/kg/h infusion. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), bispectral index (BIS) and Ramsay sedation scores (RSS) were recorded. The lowest respiratory rates (LRR), incidences of respiratory depression, incidences of oxygen supplementation by facial mask and thrusting the jaw, frequencies of body movements, and additional rescue drug administrations were also recorded. After surgery, recovery time, recall of intraoperative events, pain scores in postanesthesia care unit(PACU), and satisfaction of patients and surgeons were assessed. Results: The BIS at time points from 5 min after anesthesia to the end of surgery in the intervention group were significantly higher than those in the control group (P<0.05). The RSS scores at time points from 5 min after anesthesia to immediately after induction with DEX were significantly higher in the intervention group than those in the control group (P<0.05). The HR at time points from the beginning of surgery to 30 min after local anesthesia, the MAP at time points from 30 min after local anesthesia to the end of surgery, and the RR at time points from 5 min after anesthesia to the end of surgery were significantly higher in the intervention group than those in the control group (P<0.05). Compared with the control group, patients in the intervention group had higher LRR, lower incidences of respiratory depression, more oxygen supplementation by facial mask and thrusting the jaw, and a shorter recovery time (P<0.05). Conclusions: The two different dexmedetomidine administrations effectively sedated and provided analgesia for patients. Dexmedetomidine infused with a loading dose over 30 min had less impact on patients’ hemodynamics and respiration and could shorten the recovery time after anesthesia. Trial registration: Registered at the Chinese Clinical Trial Registry, registration number ChiCTR1900027958, date of registration: 07/12/2019.
An Investigation of the Intention and Reasons of Senior High School Students in China to Enter into Medical School
Authors: Yang Chaoqun , Jin Xuerui , Yan Ji , Zhang Junkai , Chen Canyu , Cheng Yaqing , You Jialin , Deng Guoying 
Published: December 2020

Abstract
BackgroundShortages of qualified health workers have been a global concern, especially in developing countries. China also faces this dilemma, which hinders the development of public health services. Senior high school students are a group who are considering their college majors and careers after graduation. They are also a potential and basic talent reserve for the health sector. This survey focused on senior high school students’ willingness to learn clinical medicine and explored potential influencing factors. MethodsAn anonymous questionnaire containing 16 items was distributed to 5344 senior high school students. The questions covered the following topics: students’ willingness to learn clinical medicine, personal and family information, understanding of medical education, cognition of doctors’ working conditions, and doctor-patient relationships. Logistic regression and the chi-square test were used to compare students with and without a strong willingness to learn clinical medicine to explore influencing factors. ResultsOnly 5.6% of senior high school students had a strong willingness to learn medicine (SWLCM). Personal and family information had distinct impacts. Interest and anatomy course were also associated with students’ choice. There was a positive correlation between understanding of medical education and students’ willingness. Meanwhile, students’ cognition of doctors, career prospects, and social status had significant impacts. The more optimistic students were about doctors’ working conditions and doctor-patient relationships, the more likely they were to have a SWLCM. ConclusionTo some extent, this survey reflects the shortage of medical talent in China and provides possible clues for solving this problem. In addition, these findings may provide a perspective for understanding the development of health services in developing countries.
Deubiquitinating Enzyme Inhibitor Alleviates Cyclin A1-mediated Proteasome Inhibitor Tolerance in Mixed-lineage Leukemia
Authors: Ge Maolin , Xu Qiongyu , Kang Ting , Li Dan , Wang Ruiheng , Chen Zhihong , Xie Shufeng , Wang Wenbin , Liu Han 
Published: December 2020

Abstract
Background: Drug resistance is a significant obstacle to effective cancer treatment. Drug resistance develops from initially reversible drug-tolerant cancer cells, which offers therapeutic opportunities to impede cancer relapse. The mechanisms of resistance to proteasome inhibitor (PI) therapy have been investigated intensively; however, the ways by which drug-tolerant cancer cells orchestrate their adaptive responses to drug challenges remains largely unknown. Methods: RNA sequencing and bioinformatics analyses were employed to assess dysregulated cell cycle genes. Chromatin immunoprecipitation assays were performed to evaluate the involvement of MLL in cyclin A1 transcriptional activity. Cell cycle assays, cell viability assays, immunoblots, and apoptosis assays were performed to evaluate the dependency of cyclin A1 during tolerance acquisition.Results: Here, we demonstrated that cyclin A1 suppression elicited the development of transient PI tolerance in mixed-lineage leukemia (MLL) cells. This adaptive process involved reversible down-regulation of cyclin A1, which promoted PI resistance through cell cycle arrest. PI-tolerant MLL cells acquired cyclin A1 dependency, regulated directly by MLL protein. Loss of cyclin A1 function resulted in the emergence of drug tolerance, which was associated with patient relapse and reduced survival. Combination treatment with PI and deubiquitinating enzyme (DUB) inhibitors overcame this drug resistance by restoring cyclin A1 expression through chromatin crosstalk between histone H2B monoubiquitination and MLL-mediated histone H3 lysine 4 methylation. Conclusion: These results reveal the importance of cyclin A1-engaged cell cycle regulation in PI resistance in MLL cells, and suggest that cell cycle re-entry by DUB inhibitors may represent a promising epigenetic therapeutic strategy to prevent acquired drug resistance.
Attitudes and Perspectives of Older Adults on Technologies for Assessing Frailty in Home Settings: A Focus Group Study
Authors: Bian Chao , Ye Bing , Hoonakker Anna , Mihailidis Alex 
Published: December 2020

Abstract
Background The rapid development of technology such as sensors and artificial intelligence in recent years enables monitoring frailty criteria to assess frailty early and accurately from a remote location such as a home. However, research shows technologies being abandoned or rejected by users due to a lack of compatibility and consumer involvement with the technologies. This study aims to understand older adult’s perceptions and preferences of technologies that can be potentially used to assess frailty in home settings. Methods This study is a qualitative study in which data were collected through focus group interviews. We recruited 15 older participants. Questions were asked to achieve the goal of understanding their attitudes on the technologies. These questions include 1) the concerns or barriers of installing and using the presented technology in daily life at home, 2) the reasons participants like or dislike a particular technology, 3) what makes a particular technology more acceptable, and 4) participants’ preferences in choosing technologies. Data were transcribed, coded and categorized, and finally synthesized to understand the attitudes towards presented technologies.Results A total of 15 older adults aged 65 and older were recruited. Three focus group sessions were conducted with five participants in each session. In the findings, the attitudes and perspectives of participants on the technologies for assessing frailty were presented in four areas: A) general attitude towards using the technologies, B) concerns about the technologies, C) existing living habits or patterns related to using the technologies, and D) constructive suggestions related to the technologies.Conclusions This study focuses on understanding the attitudes and perceptions of older adults on several technologies that could potentially be used to assess frailty in home settings. Participants generally have positive attitudes towards allowing the technologies to be installed and used at their home. Some technologies were found to be more acceptable if used under certain conditions. However, questions and concerns still remain. The study also found the living habits or patterns of older adults could affect the design and use of technology. Lastly, many valuable suggestions have been made by participants.
Metabolite Profiles of Energy Cane and Sugarcane Reveal Different Strategies During the Axillary Bud Outgrowth
Authors: Abreu Luís Furlan de , Silva Nicholas , Ferrari Allan Ramos , Carvalho Lucas de , Carazzolle Marcelo Falsarella , Fill Taícia Pacheco , Pilau Eduardo , Pereira Gonçalo Guimarães , Grassi Maria de Barros 
Published: December 2020

Abstract
Sugarcane (Saccharum spp.) is one of the most well-known plants which possesses a large accumulation of sucrose. Another cultivar, energy cane, is an interspecific hybrid with higher fiber and lower sugar content than sugarcane. Commercial cultivation of sugarcane and energy cane is carried out by vegetative propagation, through the distribution of culm segments (setts) or pre-sprouted seedlings (PSS). In this context, the metabolism of axillary bud outgrowth is crucial for cultures that use vegetative propagation. In this work, we evaluate the metabolic profile of sugarcane and energy cane in the early hours during the axillary bud outgrowth. Sugarcane showed few metabolic changes, except for the significant increase in glutamate levels, which may be associated with root formation in the culm. In contrast, energy cane presented significant changes in amino acid catabolism, increased levels of reducing sugars, lipids, and metabolite activity in the phenylpropanoid pathway. These results together reveal changes in the energy and redox status of the cell, electron transport for the TCA cycle, and an increase in compounds related to cell wall formation and growth in energy cane. Our study provides new insights on the regulation of the axillary bud of species of the Saccharum complex.