bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of the technocratic governance cases and deliberative-democratic self-rule in the internet-sphere
Authors: Linde A. N. 
Published: April 2020

Introduction. The paper compares two approaches to the formation of the internet-sphere. The technocratic approach strengthens itself in the cybernetic-system methodology, it is based on the technocratic governance of society and implies the total governance of the internet-sphere in the interests of the government, the suppression of the individual personality by “programming” its consciousness. This approach is evidenced by “the system of social credit” in China.The deliberative-democratic approach emerges from phenomenology and substantiates an egalitarian model of democracy which implies a universal discussion and importance of the meanings sent by each person in the internet-sphere. The case of online-deliberative forums is analyzed. These forums serve to reveal the opinions of the citizens themselves and to define the genuine public opinion. The advantages of the second approach are identified.Materials and methods. This article uses logical methods of analysis: analysis, synthesis, comparative analysis.The results of the study. This study shows how the cybernetic-systemic methodology holistically analyzing society and assuming its programming “from top to bottom” leads to technocratic governance of society and the Internet. It also shows how the phenomenological approach aimed at perceiving the personal meanings of each citizen becomes the basis of deliberative democracy and online deliberative discussions.Discussion and conclusions. The paper arrives at the following conclusions. Serious risks produced by the use of the cybernetic-systemic principles in governing the Internet sphere are shown: programming the personality consciousness, emasculating the senses experienced by it, and regulating the entire social life. In contrast with the cybernetic approach, the advantages of the phenomenological approach are analytically shown, because it perceives the personal meanings of each individual and leads to their revealing in the Internet sphere, which creates the foundation for maintaining a democratic regime.
Early Implementation of Comprehensive Medication Management within an Academic Medical Center Primary Care Pharmacy Team
Authors: Turner Kyle , Buu Jenni , Kuzel Mary , Van Wagoner Eve , Berrett Golden 
Published: April 2020

Introduction: University of Utah Health is an academic health care system that serves residents in Utah and beyond. Clinical pharmacists with the health care system’s pharmacy primary care services (PPCS) team provide medication education, population-based care, and medication management through collaborative practice agreements. With the expansion of clinical pharmacist and technician positions and services, the need to measure and assess the impact of pharmacy services and create a value proposition for internal and external stakeholders became an important goal, and the decision was made to better align practices across all PPCS sites. This paper highlights University of Utah Health’s approach to implement comprehensive medication management (CMM) across all primary care clinics with embedded clinical pharmacy staff and subsequent evaluation of implementation fidelity.
Methods: Implementation of CMM was assisted by participation in the National A3 Collaborative and by using selected principles from the Active Implementation Framework. Stages of implementation included exploration, instillation, and initiating improvement cycles. An implementation team consisting of PPCS employees was created to help with standardization, developing implementation plans, and creating a dissemination strategy for all PPCS team members. The CMM care process was subsequently presented and implemented by clinical pharmacists in primary care clinics. Following implementation, fidelity measures were collected including identification and resolution of medication therapy problems (MTPs) and responses from a questionnaire distributed to the clinical pharmacists to self-report understanding and implementation of CMM key elements. The number and type of MTPs identified were tracked over 18 months.
Results: Within the measurement window, clinical pharmacists identified 17,953 MTPs. Of the total number of MTPs identified, 21% were related to indication, 53% to efficacy, 15% to safety and 11% to adherence. The questionnaire was distributed to clinical pharmacists 9 months after CMM implementation, with a 71% response rate. Pharmacists reported “always” or “often” performing each step in the patient care process as follows: indication (93%), effectiveness (93%), safety (87%), and adherence (93%). Reported barriers to implementation of the CMM include lack of time to complete all aspects of the process efficiently, lack of a standardized format for documentation, and changing practice habits.
Conclusion: Implementation of a CMM process within University of Utah Health’s PPCS services with the help of a national collaborative and implementation framework yielded identification of 17,953 MTPs over 18 months and foundational fidelity to core principles.

Article type: Clinical Experience
Peran dan Strategi Perguruan Tinggi dalam Menghadapi Era Society 5.0
Authors: Setiawan Dimas , Lenawati Mei 
Published: April 2020

Perkembangan teknologi sistem informasi berkembang cukup pesat sehingga berdampak pada bermunculannya trend dari Revousi Industri 4.0 dan Society 5.0. Perguruan Tinggi merupakan salah satu Lembaga yang berkontribusi dalam kegiatan pendidikan di Indonesia tentunya harus mampu beradaptasi dalam menghadapi beberapa trend yang berkembang tak terkecuali trend Society 5.0. Upaya yang bisa dilakukan adalah memahami peran serta strategi yang perlu dilakukan perguruan tinggi dalam menghadapi era Society 5.0, dengan melakukan studi literatur mengenai Konsep Society 5.0 dan proses analisa data menggunakan metode analisa TOWS diharapan dapat menemukan peran serta strategi yang bisa dijadikan sebagai referensi kebijakan bagi perguruan tinggi dalam menghadapi tantangan di era Revolusi Industri 4.0 saat ini dan Society 5.0 kedepannya. Selain itu diperlukan komparasi keterkaitan anatra society 5.0 dengan Revolusi industri 4.0 dan SDGs sebagai data tambahan dalam menyusun peran dan strategi perguruan tinggi.
Anti-diabetic activity of silver nanoparticles prepared from cumin oil using alpha amylase inhibitory assay
Authors: R Preety , Anitha Roy , S Rajeshkumar , T Lakshmi 
Published: April 2020

Studies suggest that cumin oil have many health and cosmetic benefits such as weight loss, improving skin conditions and also treating cancer and diabetes. People have used these tiny black seeds of N. sativa as a natural remedy for thousands of years. Cumin oil contains thymoquinone, which is an antioxidant and an anti-inflammatory compound having tumor-reducing properties therefore useful in treating cancer. Plant mediated biological synthesis of silver nanoparticles has been gaining importance due to its simplicity and eco-friendliness. The aim of the present study was to prepare cumin oil mediated silver nanoparticles and evaluate it for its anti-diabetic activity .using alpha amylase inhibitory assay. The green synthesised cumin oil mediated silver nanoparticles were prepared using 1mM silver nitrate. The anti-diabetic activity was evaluated by alpha amylase inhibitory assay. The formation of the nanoparticles was confirmed both by visual colour change as well as by scanning the absorbance by UV-Visible spectrophometer between 300 nm to 700 nm. In the present study, cumin oil mediated silver nanoparticles inhibited alpha amylase in a dose dependent manner. Hence, these nanoparticles may be used for control post prandial hyperglycemia
Application of design mixture and desirability function in the optimization of pharmaco-technical parameters of macrogols-based suppositories
Authors: Abdelhafid Benomar  , Siham Yanisse  , Naoual Charkaoui  , Abdelkader Laatiris  , Yassir Alaoui  , Aicha Fahry  
Published: April 2020

The objective of this work is to (i) study the effect of variations in the proportions of four Macrogols on the pharmaco-technical characteristics of suppositories, (ii) define the optimal formula for a suppository with immediate effect; maximum disintegration and a minimum of hardness as defined in the European Pharmacopoeia. The lattice design mixture has been proposed as an optimization technique, the formulation factors are presented by the proportions of PEG 400 (X1), PEG 600 (X2), PEG 4000 (X3) and PEG 6000 (X4) and the response variables are (i) the disintegration time (Y1) (ii) the hardness (Y2). The second-degree empirical model was postulated to model the variations of the two response variables using the least-squares method. The selected model explained about 67% and 84% of the variation for Y1 and Y2, respectively. All four factors had significant effects on the properties of the suppository. Interactions negatively affected both responses. The numerical desirability method gave the following optimal formula: PEG400 (28.71334 %); PEG600 (24.23773%), PEG4000 (35.00944%) and PEG6000 (12.03949%) for a disintegration of 25.839 (+/-2.3) min and hardness =2147.321 (+/- 50) g.
Cardioprotective Effect of Ethanolic Flower Extract of ClitoriaTernatea on Doxorubicin Induced Cardiotoxicity in Rats
Authors: A Tamizhselvi , S Durairaj , A Mohamed Sadiq , G Gopinath , S Rajeshkumar 
Published: April 2020

There was a significant evidence that there are several of the medicinal plants encompass the prospective to treat cardiovascular disease. In this study, Doxorubicin is used as an effectual induction of cardiotoxicity and heart malfunction in the taken experimental rats which is an anthracycline chemotherapeutic mediator used to the treat of a wide variety of malignancies. To examine the shielding property of ethanolic flower extract of clitoraternatea (EECT) scheduled doxorubicin(DOX) persuaded cardiotoxicity via albino wistar rats,through inspect the enzymatic,non-enzymatic antioxidant position,serum enzyme and Histopathology tissue.Experimental rats been provoked cardiotoxicity by means of a generous single dose of doxorubicin (15mg /body weight ) and treated orally through an ethanolic extract of clitoraternatea (EECT) for 14 days (100 mg/kg bw, 200 mg/kg bw and 300mg/kg bw,n=5).On15 days, the rats are sacrificed by treated through Ketamine –Xylazine,Biochemical as well as histological remarks of the heart tissues had carry out. Cardiotoxicity had been calculated throughout to establish the cardio marker enzyme levels such as (LDH) Lactic acid dehydrogenase,(CK-MB) Creatinin kinase and (AST) Aspartate transaminase at the finish of the study. Managementthrough EECT of 200mg/kg and 300mg/kgconsiderablyreduced the levels of cardiac marker enzymes(p<0.05), and as wellminimize the decrease of weight of the heart of DOX treated group. In heart tissue superoxide dismutase, glutathione and catalase heightsbe significantly greater than before and lipid oxide peroxide (LPO) significantly decreased in the extract (200 &300 mg /kg bw) treated rats when compared to DOX treated with the significance of P< 0.05. There was no significant recovery of the 100 mg/kg of EECT. These results will suggested that EECT having potential anti-cardiotoxic effects induced by Doxorubicin by preventing oxidative injure provoke by DOX in heart of taken experimental animals.
Box-Behnken experimental design for extraction optimization of cytotoxic activity from Curcuma aeruginosa rhizome
Authors: Khoiriyah Rani , I Made Artika , Nurcholis Waras 
Published: April 2020

Curcuma aeruginosa is the common name of temuhitam in Indonesia, and the rhizome of parts plant had several pharmacological activities. Generally, pharmacological activities were associated with bioactive content in the extract of medicinal plants. Several factors can influence the bioactive extraction from medicinal plants such as solvent types, extraction time, extraction technique, and liquid-to-solid ratio. In this research, the extraction factors for extraction yield and cytotoxic activity of C. aeruginosa rhizome were optimized using the Box-Behnken experimental design. Effect of ethanol concentration, the ratio of liquid to solid, and extraction time for the maceration process was studied. The cytotoxic activity was determined by the brine shrimp lethality test. The optimum value that maximizes the extraction yield was 70 % ethanol, 300:15 ml/g liquid to solid ratio, and 1-day extraction time. The optimum value that maximizes the cytotoxic activity was 70 % ethanol, 150:15 ml/g liquid to solid ratio, and 2-day extraction time. The predicted extraction yield and cytotoxic activity at these projected values are 14.78 % and 78.26 mg/l, respectively. In this model, Adeq Precision (10.35 and 4.16), R-Squared (0.86 and 0.79), and F-value (7.92 and 2.04) is rational to fit the model for extraction yield and cytotoxic activity from C. aeruginosa rhizome.
Hubungan Pengetahuan Ibu Tentang Stimulasi Perkembangan Anak Dengan Keterampilan Ibu Dalam Melakukan Stimulasi Perkembangan Anak
Authors: Susanti Neny Yuli , Adawiyah Robiatul 
Published: April 2020

Knowledge about children and have skills of stimulating needs of children at each stage of development, so that children's intelligence can develop with maximum age. Age 0-2 years is a very important time considering the brain development occurs very rapidly at the age under 2 years, this is called a critical period of development, and is a good time to make a recovery, if there is a developmental disorder. Technique of collecting knowledge data using questionnaire sheet and skill data using Checklist executed at May 2018. Data analysis using statistical test with SPSS software that is "Chi Square" test by using scale/data ordinal and nominal, with level maximize α = 0,010. The results showed that the statistical test results obtained p value of 0.000 <0,05 so that H0 rejected which means there is relationship of mother knowledge about child development with skill of mother doing age stimulation 0-2 year.
Evidence for a Cultural Mindset: Combining Process Data, Theory, and Simulation
Authors: Holden LaTasha R , LaMar Michelle , Bauer Malcolm 
Published: April 2020

The goal of the present work is to build a foundation for understanding cognition and decision-making processes in innovative assessment contexts. Specifically, we will assess students’ Cross-Cultural Competence (3C: see Thomas et al., 2008) through a social simulation game. The present work will use Mindset (i.e., individuals beliefs about whether ability is fixed or changeable, see Dweck, 2006) to ground the project in theory because it has been shown to be a powerful motivator for decision-making and behavior in learning and achievement (Dweck &amp; Leggett; 1988; Dweck, 1999), and in cross-cultural contexts (Dweck, 2012). The novel contribution of this paper is to apply Mindset theory to social situations requiring 3C, thus proposing the notion of cultural mindsets—defined here as the set of beliefs including affect, cognition, and behavior people bring to cross-cultural contexts. In cultural mindset, affect and cognition govern the ease with which people adapt, learn, and update cultural information. Additionally, we argue that cultural mindsets are important mechanisms involved in navigating cross-cultural situations effectively and should be considered more in future research. In order to understand how cultural mindset affects student performance, we will apply a computational cognitive modeling approach using Markov decision process (MDP) models. The MDP approach is appropriate for sequential decision-making in non-deterministic environments—as actions are chosen as part of a plan to achieve goals with the knowledge that some action effects will be probabilistic.
Periodontal Parameters Alterations with Use of Conventional Bracket and Self-ligating Brackets
Authors: Bajracharya Manish , Gorkhali Ranjita Shrestha , Khanal Abhilasha , Shrestha Neesha , Parajuli Umesh 
Published: April 2020

Introduction: Different bracket systems are available in the market claiming to have some advantage over the other. Conventional brackets and the self-ligating brackets are the most common. Though both the systems work basically similarly, the difference between the two system is principally in the ligating technique. The advantage of conventional brackets claimed are faster tooth movements and improved oral health of the patient.
Materials & Method: A total number of 20 patients were shorted from the waiting list meeting the selection criteria. With the help of random number generator, two groups with 10 subjects each were created for conventional brackets (0.022 Slot MBT brackets) and self-ligating brackets (0.022 Slot DAMON prescription) respectively. The patients were blinded regarding the selection of the brackets. The brackets were bonded according to the random number allocation. After the bonding, the periodontal parameters i.e. gingival index (GI), plaque Index (PI) were measured again at an interval of 60 (T1) and 120 days (T2). Periodontal indices were calculated by summing the mean score of each examined tooth and dividing by the number of the evaluated teeth. Data collection was done with the help of a periodontal probe. All the records were taken by the same periodontist to avoid inter-examiner variability. To reassure that there is no any intra-examiner variation for periodontal status, the same periodontist re-measured the periodontal parameters again of 10 individuals selected randomly after 7 days from the initial measurements. To examine the intra-examination variability, Dahlberg’s formula was used between the two readings taken at a span of 7 days of the same subjects. The mean value of Plaque index and Gingival index was checked for normal distribution applying Kolmogorov- Smirnov test. One-way ANOVA test was applied for comparison between and within groups for plaque index and Gingival index during three different period in Conventional brackets and Self-ligating brackets. Post hoc Bonferroni test was applied for multiple comparison. Independent t-test was applied for comparison between conventional brackets and self-ligating brackets to compare the plaque index and gingival index. All data were test were analyzed at P<0.05.
Result: There was no any significant difference between T0 and T1 and between T1 and T2 in both the conventional brackets and self-ligating brackets. However, there was statistical difference between the time period from T0 to T2. There was also no any significant difference between conventional bracket and self-ligating brackets in terms of plaque index and gingival index.
Conclusion: There are no advantages of self-ligating brackets over conventional brackets in terms of periodontal status.
Prediction of Combined Mesiodistal Width of Unerupted Permanent Canine and Premolars using Moyer’s Mixed Dentition Analysis in Nepalese Newar Population
Authors: Shrestha Amrita , Pradhan Dilesh 
Published: April 2020

Introduction: Moyer’s probability table is most commonly used to predict the mesiodistal width of permanent canines and premolars in mixed dentition. However, the table was formulated using data from Caucasian population. This study was performed to compare the Moyer’s prediction table with actual value in Nepalese Newar population as ethnicity is one of the important factor to determine teeth width.
Materials & Method: Combined mesiodistal width of permanent canine and premolars were measured in 150 study models of Nepalese Newar orthodontic patients (75males and 75 females). The value was compared with the Moyer’s prediction table at all probability level.
Result: There was no statistically significant difference between the actual combined width and that predicted from Moyer’s table at 85% probability level for maxilla and at 75% level for mandible in male, at 95% probability level for maxilla and at 85% probability level for mandible in female.
Conclusion: Moyer’s probability level can be used to predict the combined mesiodistal width of permanent canines and premolars in Nepalese Newar population but at specific probability level.
VEGETATIVE REACTIVITY AND VEGETATIVE SUPPLY IN DIFFERENT VARIANTS OF GASTROESOPHAGEAL REFLUX DISEASE IN YOUNG PATIENTS WITH AUTOIMMUNE INFLAMMATION
Authors: Pasiieshvili T.M. 
Published: April 2020

Aim: to determine the state and role of autonomic reactivity and autonomic supply in patients with different manifestations of gastroesophageal reflux disease in combination with autoimmune thyroiditis through psychological testing by using a questionnaire of A.M. Vejn.
Materials and methods. 87 patients with gastroesophageal reflux disease and autoimmune thyroiditis and 45 persons with an isolated gastroesophageal reflux disease were enrolled in the study. All the examined individuals were students.
Results. It has been shown that the course of diseases is accompanied by a layering of clinical manifestations of autonomic dysfunction, which are more pronounced in cases of comorbidities. It has been found out that vegetative supply prevails in a number of indicators in the patients with an erosive form of gastroesophageal reflux disease. It has been proven that in almost all the cases of erosion (8 people - 72.7%), the individuals experienced some clinical manifestations of vegetative provision, such as general weakness, increased fatigue, lability of the pulse and blood pressure, and palpitation. At the same time, the “vegetative tail” was recorded only in a third (34.7%) of the studied without erosive lesions of the esophageal mucous membrane. The patients with an erosive form of the disease have a long period of experiencing some manifestations of autonomic dysfunction (up to 3 months) that considerably affects the quality of their life.
Conclusions. Coupling of autoimmune thyroiditis and gastroesophageal reflux disease leads to the emergence of autonomic reactivity. Vegetative “supply” of the course of comorbidity between gastroesophageal reflux disease and autoimmune thyroiditis becomes more pronounced in the presence of an erosive process in the mucous membrane, which is also known as one of the factors of its possible manifestations.