bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of adding angiotensin receptor neprilysin inhibitors to usual care in patients with heart failure: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
Authors: Nielsen Emil Eik , Feinberg Joshua , Raymond Ilan , Olsen Michael Hecht , Steensgaard-Hansen Frank Victor , Jakobsen Janus Christian 
Published: October 2019

Abstract

Background
Heart failure is a highly prevalent disease with a global prevalence of 37 million, and the prevalence is increasing. Patients with heart failure are at an increased risk of death and morbidity. Traditionally, patients with heart failure have been treated with a beta-blocker in addition to an inhibitor of the renin-angiotensin-aldosterone system. However, new drugs are currently being added to the recommended guideline therapy. The latest drug to be added combines inhibition of the renin-angiotensin-aldosterone system pathway with inhibiting the neprilysin enzyme and is therefore classified as an ARNI. Our objective is to identify the beneficial and harmful effects of ARNIs in the treatment of patient with heart failure.

Methods
This protocol for a systematic review was undertaken using the recommendations of the Cochrane, the Preferred Report Items of Systematic reviews with Meta-Analysis Protocols, and the eight-step assessment procedure suggested by Jakobsen and colleagues. We plan to include all relevant randomised clinical trials assessing the use of ARNIs in the treatment of patients with heart failure. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Latin American and Caribbean Health Sciences Literature (LILACS), Science Citation Index Expanded on Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science Journal Database (VIP), and BIOSIS to identify relevant trials. We will also search for grey literature and unpublished trials. Extracted data will be analysed using Review Manager 5, STATA 5, and Trial Sequential Analysis. Our primary outcomes will be all-cause mortality and serious adverse events. We will create a ‘Summary of Findings’ table in which we will present our primary and secondary outcomes, and we will assess the quality of evidence using the GRADE assessment.

Discussion
The present systematic review will have the potential to aid clinicians in decision-making and thereby, benefit patients with heart failure.

Systematic review registration
PROSPERO CRD42019129336
Suppressed N fixation and diazotrophs after four decades of fertilization
Authors: Fan Kunkun , Delgado-Baquerizo Manuel , Guo Xisheng , Wang Daozhong , Wu Yanying , Zhu Mo , Yu Wei , Yao Huaiying , Zhu Yong-guan , Chu Haiyan 
Published: October 2019

Abstract

Background
N fixation is one of the most important microbially driven ecosystem processes on Earth, allowing N to enter the soil from the atmosphere, and regulating plant productivity. A question that remains to be answered is whether such a fundamental process would still be that important in an over-fertilized world, as the long-term effects of fertilization on N fixation and associated diazotrophic communities remain to be tested. Here, we used a 35-year fertilization experiment, and investigated the changes in N fixation rates and the diazotrophic community in response to long-term inorganic and organic fertilization.

Results
It was found that N fixation was drastically reduced (dropped by 50%) after almost four decades of fertilization. Our results further indicated that functionality losses were associated with reductions in the relative abundance of keystone and phylogenetically clustered N fixers such as Geobacter spp.

Conclusions
Our work suggests that long-term fertilization might have selected against N fixation and specific groups of N fixers. Our study provides solid evidence that N fixation and certain groups of diazotrophic taxa will be largely suppressed in a more and more fertilized world, with implications for soil biodiversity and ecosystem functions.
An initial performance review of vaginal implant transmitters paired with GPS collars
Authors: Dion Justin R. , Haus Jacob M. , Rogerson Joseph E. , Bowman Jacob L. 
Published: October 2019

Abstract

Background
The vaginal implant transmitter is an effective tool in the study of neonatal survival rates for cervid species. The latest iterations of the vaginal implant transmitter use Global Positioning Systems and ultra-high frequency telemetry technology to create a self-monitoring system in which researchers receive near instantaneous notifications of parturition events via remote transmission. We deployed ultra-high-frequency radio-linked vaginal implant transmitters on 44 adult female white-tailed deer (Odocoileus virginianus) and assessed their performance and possible benefits to field research.

Results
In 2016, 60% of the females expelled transmitters at the birth sites. Failure to locate a birth site was a result of technological failings (20%) and premature expulsions (20%). Following manufacturer updates in 2017, we observed an apparent reduction in technology malfunctions (8%) but similar rates of premature expulsions (33%), which resulted in 58% of radio-linked transmitters expelled at birth sites. We located similar numbers of neonates per device across both years. The likelihood that researchers would locate > 1 neonate at or near the birth site was greater for radio-linked transmitters than has been reported in studies using traditional vaginal implant transmitters.

Conclusions
Radio-linked transmitters allow researchers to increase sample size, expand spatial distribution of study animals, and reduce personnel requirements.
To cross or not to cross – thrushes at the German North Sea coast adapt flight and routing to wind conditions in autumn
Authors: Brust Vera , Michalik Bianca , Hüppop Ommo 
Published: October 2019

AbstractBackgroundAlthough many aspects of passerine migration are genetically determined, routing appears to be flexibly adjusted to the conditions experienced on each individual journey. This holds especially true for routing decisions taken when confronted with large bodies of water. Once taken, these decisions can be hardly altered or revised. In this paper, we analysed stopover and routing decisions taken by three species of thrushes, blackbirds, redwings and song thrushes, at the German North Sea coast.MethodsBirds were equipped with radio-telemetry tags at stopover sites along the coast during autumn migration and subsequently tracked by an automated receiver network covering the coastline and islands of the German Bight.ResultsThe thrushes resumed migration in nights with a favourable northward wind component and clear skies. About 40% of the tagged individuals have taken an offshore instead of an alongshore oriented flight route. Routing decisions were influenced by the strength of the eastward wind component with offshore oriented flights taking place primarily under weak winds or winds blowing towards the west. Thrushes that took an offshore oriented route stopped over at the coast longer than those flying alongshore. Interestingly, offshore as well as alongshore oriented flights co-occurred within single nights and under comparable weather conditions.ConclusionsMigratory flight and routing decisions of thrushes at the German North Sea coast are highly dependent on weather, in particular wind. Still, we found evidence that weather may not be the sole reason for individual routes taken. Physical condition, morphology or animal personality lend themselves as possible additional factors of influence. Enabling a more detailed understanding of thrush migration over and along the German North Sea, our data help to better judge risks that migratory birds are facing when en route conditions are altered, for example by artificial obstacles such as offshore wind turbines.
A graphical heuristic for reduction and partitioning of large datasets for scalable supervised training
Authors: Yadav Sumedh , Bode Mathis 
Published: October 2019

Abstract
A scalable graphical method is presented for selecting and partitioning datasets for the training phase of a classification task. For the heuristic, a clustering algorithm is required to get its computation cost in a reasonable proportion to the task itself. This step is succeeded by construction of an information graph of the underlying classification patterns using approximate nearest neighbor methods. The presented method consists of two approaches, one for reducing a given training set, and another for partitioning the selected/reduced set. The heuristic targets large datasets, since the primary goal is a significant reduction in training computation run-time without compromising prediction accuracy. Test results show that both approaches significantly speed-up the training task when compared against that of state-of-the-art shrinking heuristics available in LIBSVM. Furthermore, the approaches closely follow or even outperform in prediction accuracy. A network design is also presented for a partitioning based distributed training formulation. Added speed-up in training run-time is observed when compared to that of serial implementation of the approaches.
Comparative effectiveness of Biobrane®, RECELL® Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol
Authors: Bairagi Anjana , Griffin Bronwyn , Tyack Zephanie , Vagenas Dimitrios , McPhail Steven M. , Kimble Roy 
Published: October 2019

Abstract

Background
Mixed partial thickness burns are the most common depth of burn injury managed at a large Australian paediatric hospital specialty burns unit. Prolonged time until re-epithelialisation is associated with increased burn depth and scar formation. Whilst current wound management approaches have benefits such as anti-microbial cover, these are not without inherent limitations including multiple dressing changes. The Biobrane® RECELL® Autologous skin Cell suspension and Silver dressings (BRACS) trial aims to identify the most effective wound management approach for mixed partial thickness injuries in children.

Methods
All children presenting with an acute burn injury to the study site will be screened for eligibility. This is a single-centre, three-arm, parallel group, randomised trial. Children younger than 16 years, with burns ≥ 5% total body surface area involving any anatomical location, up to 48 h after the burn injury, and of a superficial partial to mid-dermal depth, will be included. A sample size of 84 participants will be randomised to standard silver dressing or a Regenerative Epithelial Suspension (RES™) with Biobrane® or Biobrane® alone. The first dressing will be applied under general anaesthesia and subsequent dressings will be changed every 3 to 5 days until the wound is ≥ 95% re-epithelialised, with re-epithelialisation time the primary outcome. Secondary outcomes of acute pain, acute itch, scar severity, health-related quality of life, treatment satisfaction, dressing application ease and healthcare resource use will be assessed at each dressing change and 3, 6 and 12 months post-burn injury.

Discussion
The findings of this study can potentially change the wound management approach for superficial partial to mid-dermal burns in children locally and worldwide.

Trial registration
The Australian New Zealand Clinical Trials Registry (ACTRN12618000245291) approved prospective registration on 15 February 2018. Registration details can be viewed at https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374272&isReview=true.
Using learning analytics to develop early-warning system for at-risk students
Authors: Akçapınar Gökhan , Altun Arif , Aşkar Petek 
Published: October 2019

Abstract
In the current study interaction data of students in an online learning setting was used to research whether the academic performance of students at the end of term could be predicted in the earlier weeks. The study was carried out with 76 second-year university students registered in a Computer Hardware course. The study aimed to answer two principle questions: which algorithms and features best predict the end of term academic performance of students by comparing different classification algorithms and pre-processing techniques and whether or not academic performance can be predicted in the earlier weeks using these features and the selected algorithm. The results of the study indicated that the kNN algorithm accurately predicted unsuccessful students at the end of term with a rate of 89%. When findings were examined regarding the analysis of data obtained in weeks 3, 6, 9, 12, and 14 to predict whether the end-of-term academic performance of students could be predicted in the earlier weeks, it was observed that students who were unsuccessful at the end of term could be predicted with a rate of 74% in as short as 3 weeks’ time. The findings obtained from this study are important for the determination of features for early warning systems that can be developed for online learning systems and as indicators of student success. At the same time, it will aid researchers in the selection of algorithms and pre-processing techniques in the analysis of educational data.
Indicator for local recurrence of hepatocellular carcinoma after proton beam therapy: analysis of attenuation difference between the irradiated tumor and liver parenchyma on contrast enhancement CT
Authors: Takahashi Hiroaki , Sekino Yuta , Mori Kensaku , Okumura Toshiyuki , Nasu Katsuhiro , Fukuda Kuniaki , Masuoka Sota , Iizumi Takashi , Hasegawa Naoyuki , Sakurai Hideyuki , Minami Manabu 
Published: October 2019

Objectives:
We aimed to identify dynamic CT features that can be used for prediction of local recurrence of hepatocellular carcinoma (HCC) after proton beam therapy (PBT).

Methods:
We retrospectively retrieved CT scans of patients with PBT-treated HCC, taken between January 2004 and December 2016. 17 recurrent lesions and 34 non-recurrent lesions were retrieved. The attenuation difference between irradiated tumor and irradiated parenchyma (ADHCC-IP) was compared in the two groups by using the Mann–Whitney U test. Cut-off value of ADHCC-IP was estimated by using the Youden index.

Results:
The follow-up time after PBT initiation ranged from 374 to 2402 days (median, 1069 days) in recurrent lesions, and 418 to 2923 days (median, 1091.5 days) in non-recurrent lesions (p = 0.892). The time until appearance of local recurrence after PBT initiation ranged from 189 to 2270 days (median, 497 days). ADHCC-IP of recurrent lesions [mean, −21.8 Hounsfield units (HU); from −95 to −31 HU] was significantly greater than that of non-recurrent lesions (mean, −51.7 HU; from −117 to −12 HU) at 1–2 years in portal venous phase (p = 0.039). 5-year local tumor control rates were 0.93 and 0.56 in lesions with ADHCC-IP at 1–2 years in PVP &lt; −55 and ≥ −55 HU, respectively.

Conclusion:
The attenuation difference between irradiated HCC and irradiated liver parenchyma in portal venous phase at 1-2 years after PBT can predict long-term local recurrence of HCC after treatment.

Advances in knowledge:
We identified a cut-off value for contrast enhancement of HCC after PBT that could predict future local recurrence.
Small masses (≤3 cm) diagnosed as hepatocellular carcinoma on pre-treatment imaging: comparison of therapeutic outcomes between hepatic resection and radiofrequency ablation
Authors: Cha Dong Ik , Song Kyoung Doo , Kang Tae Wook , Lee Min Woo , Rhim Hyunchul 
Published: October 2019

Objective:
To compare therapeutic outcomes between hepatic resection (HR) and radiofrequency ablation (RFA) for small hepatic masses diagnosed as hepatocellular carcinoma (HCC) on pre-treatment imaging study.

Methods:
Our institutional review board approved this retrospective study, and informed consent was waived. Patients with a single (≤3 cm) mass diagnosed as HCC on pre-treatment imaging study between January 2008 and December 2009 who underwent HR (n = 145) or RFA (n = 178) were included. Recurrence-free survival (RFS) and overall survival (OS) were assessed. In the HR group, the false-positive rate for imaging diagnosis was calculated. For the RFA group, the local tumor progression rate was calculated.

Results:
RFS rates at 5 years were 59.3% for the HR group and 32.2% for the RFA group. OS rates at 5 years were 85.4% for the HR group and 76.8% for the RFA group. In the RFA group, cumulative local tumor progression rates were 8.3 and 20.2% at 1 and 3 years. Treatment modality was not an independent prognostic factor for either RFS or OS on multivariate analysis. The false-positive rate for HCC diagnosis based on imaging criteria was 4.8% in the HR group.

Conclusion:
The imaging criteria for diagnosis of HCC have a high positive predictive value. Multivariate analysis showed that RFS and OS rates were not significantly different between HR and RFA for small hepatic masses diagnosed as HCC on pre-treatment imaging.

Advances in knowledge:
Treatment modality (hepatic resection vs RFA) was not an independent prognostic factor for both RFS and OS for small masses (≤3 cm) diagnosed as hepatocellular carcinoma on pre-treatment imaging.
CT-like MRI using the zero-TE technique for osseous changes of the TMJ
Authors: Lee Chena , Jeon Kug Jin , Han Sang-Sun , Kim Young Hyun , Choi Yoon Joo , Lee Ari , Choi Jong Hoon 
Published: October 2019

Objective: This study was conducted to assess the clinical usability of the zero-echo time (ZTE) technique of MRI for evaluating bone changes of the temporomandibular joint (TMJ) in comparison with CBCT. Methods: Twenty patients with TMJ disorder who underwent both CBCT and MRI were randomly selected. CBCT images were obtained with an Alphard 3030 device (Asahi Roentgen Ind., Co. Ltd, Kyoto, Japan). MRIs were obtained using a 3.0 T scanner (Pioneer; GE Healthcare, Waukesha, WI, USA) and a 21-channel head coil. An isotropic three-dimensional proton-density-weighted ZTE sequence was acquired. Two radiologists evaluated 40 joints of 20 patients for the presence of the following osseous changes: flattening, erosion, osteophyte and sclerosis of the condyle; and flattening, erosion and sclerosis of the articular fossa. CBCT and ZTE-MRI assessments were performed at a 2-month interval. The prevalence-adjusted and bias-adjusted κ statistic was used to analyse interexaminer and intraexaminer agreement and the agreement between ZTE-MRI and CBCT. Results: Intraexaminer and interexaminer agreement analyses of ZTE-MRI showed high reproducibility (κ>0.80), which was comparable to that of CBCT. Flattening, osteophyte and sclerosis of the condyle and all types of bone changes in the mandibular fossa showed nearly perfect agreement between CBCT and ZTE-MRI (κ = 0.80–0.90). Erosion of the condyle showed substantial agreement between both sets of images (κ = 0.65–0.70). Conclusions: It is suggested that ZTE-MRI provides clinically reliable images for bone assessment in TMJ disorder. MRI may become a beneficial diagnostic tool for patients with both TMJ disc and bone pathology, with advantages involving medical costs and radiation dose.
Przemiany we współczesnej Francji w kontekście zacierania się granic kulturowych – perspektywa kulturoznawcza na wybranych przykładach
Authors: Moreno-Kamińska Natalie 
Published: October 2019

Transformations in Contemporary France in the Context of Considering Cultural Borders – A Cultural Perspective in Selected Case Studies
Culture in France, as well as its society, is changing. Mobility, the decline of traditional religiosity, and the takeover of global cultural patterns are just a few manifestations of the evolution of French contemporary culture. Based on the concept of culture transfer by French scientists, Michel Espagne and Michael Werner, and Gordon Mathews’ “cultural supermarket”, the author will present examples and effects of infiltration of foreign cultures and attempts to maintain the distinctiveness and cultural identity of the French.
„Bibliofilskie przekraczanie granic”
Authors: Skubisz Joanna 
Published: October 2019

“Borders Crossed by Bibliophiles”: Dutch 17th‑century Emblem Collections in the Possession of the University of Wrocław Library
The University Library in Wrocław has a rich collection of old works from the Netherlands, which proves that in the old days academic and bibliophilic research was carried out in the Silesian region. The works reflect various cultural, academic and religious connections between the inhabitants of Silesia and the ones of Western Europe. The printed texts give evidence confirming that Silesian bibliophiles purchased books abroad, as well as from the local book sellers. Thus, they participated in the academic and cultural movements of that time. The paper is to present the Dutch emblem volumes that are in the possession of the University Library in Wrocław, and especially how they made their way from the Netherlands to Silesia. A number of questions arise: why Silesian collectors used to buy works written in Dutch and whether that did not create a cognitive barrier for them. What kind of motivation could have inspired them to buy those books? Was it the so‑called peregrination academica that encouraged people to study in the Netherlands? What I would like to do as well is to show unlimited passions of library owners who were open‑minded to different fields of interest, which was reflected in their book collections that now are a part of the Library in Wroclaw.
Comparison of Baumgaertner and Chang reduction quality criteria for the assessment of trochanteric fractures
Authors: Mao Wei , Ni Haofei , Li Linli , He Yiqun , Chen Xujun , Tang Han , Dong Youhai 
Published: October 2019

ObjectivesDifferent criteria for assessing the reduction quality of trochanteric fractures have been reported. The Baumgaertner reduction quality criteria (BRQC) are relatively common and the Chang reduction quality criteria (CRQC) are relatively new. The objectives of the current study were to compare the reliability of the BRQC and CRQC in predicting mechanical complications and to investigate the clinical implications of the CRQC.MethodsA total of 168 patients were assessed in a retrospective observational study. Clinical information including age, sex, fracture side, American Society of Anesthesiologists (ASA) classification, tip-apex distance (TAD), fracture classification, reduction quality, blade position, BRQC, CRQC, bone quality, and the occurrence of mechanical complications were used in the statistical analysis.ResultsA total of 127 patients were included in the full analysis, and mechanical complications were observed in 26 patients. The TAD, blade position, BRQC and CRQC were significantly associated with mechanical complications in the univariate analysis. Only the TAD (p = 0.025) and the CRQC (p < 0.001) showed significant results in the multivariate analysis. In the comparison of the receiver operating characteristic curves, the CRQC also performed better than the BRQC.ConclusionThe CRQC are reliable in predicting mechanical complications and are more reliable than the BRQC. Future studies could use the CRQC to assess fracture reduction quality. Intraoperatively, the surgeon should refer to the CRQC to achieve good reduction in trochanteric fractures. Cite this article: Bone Joint Res 2019;8:502–508. DOI: 10.1302/2046-3758.810.BJR-2019-0032.R1.