bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship Between Depression and Menopause Symptoms: The PATH Model
Authors: Jenabi Ensiyeh , Fereidooni Bita , Khazaei Salman , Hamzehei Ronak , Tapak Leili 
Published: August 2020

Background:
To date, no study has been performed on the relationship between depression
and perimenopausal symptoms using the Path model in Iran.

Objective:
This study aims to assess the relationship between depression and menopause symptoms
using the PATH model.

Methods:
A cross-sectional study was conducted for 4 months, in 2019, and 332 menopausal
women were enrolled in 14 public health centers. Data collection instruments included questionnaires
of demographic characteristics, anxiety instrument, Menopause Rating Scale, and the Beck
Depression short Inventory (BDI-S). The hypothesized mediators were assessed using Structural
Equation Modeling (SEM). The model included depression symptoms (dependent variable), anxiety
(mediators), number of alive children (moderator), and menopausal symptoms (independent variable).
Analyses were conducted by SPSS 16 and AMOS 20.

Results:
There was a significant positive correlation between menopause symptoms with total anxiety
(Rs=0.52), state anxiety (Rs=0.47), trait anxiety (Rs=0.46), and depression (Rs=0.54). Depression
had a significant positive correlation with total anxiety (Rs=0.64), trait anxiety (Rs=0.58), and state
anxiety (Rs=0.59). Also, the total mediating effect of total anxiety and depression and the total
moderating effect of the number of alive children were significant on menopause symptoms.

Conclusion:
According to the results of the present study, there is an association between depression
and menopausal symptoms. Therefore, health providers should pay more attention to the psychological
health of women during the perimenopausal period. The predictor factors should be considered
in both intervention and clinical assessment of menopause women.
Development of an Electrochemical DNA Biosensor Based on Gold Nanoparticles and Thiol Graphene Nanocomposite for Detection of a Specific nuc Gene from Staphylococcus aureus
Authors: Yan Lijun , Shao Bo , Zhang Xiaoping , Niu Yanyan , Dang Wendi , Cheng Hui , Li Guangjiu , Sun Wei 
Published: August 2020

Background::
An electrochemical DNA biosensor based on gold nanoparticles (AuNPs)
and thiol graphene (TGR) nanocomposite modified carbon ionic liquid electrode (CILE) was developed
to detect a specific nuc gene of Staphylococcus aureus, which was further used in the analysis
of PCR amplification samples from unfrozen pork.

Objective::
The development of a DNA biosensor derived from AuNPs-coated TGR could be used
as a novel sensing method for the detection of specific ssDNA sequences in biological and clinical
samples.

Methods:
The electrochemical properties of modified CILE electrodes were determined by cyclic
voltammetry and electrochemical impedance spectroscopy, and the electrochemical performances
of the biosensor were investigated by differential pulse voltammetry.

Results::
This gene sensor was able to detect the specific nuc gene from Staphylococcus aureus
over the concentration range from 1.0×10-15 mol L-1 to 1.0×10-6 mol L-1 with a limit of detection of
4.5×10-16 mol L-1 (3σ), and it was applied in the detection of Staphylococcus aureus in an unfrozen
pork sample after PCR amplification of the nuc gene with satisfactory results.

Conclusion::
This gene biosensor showed high sensitivity and good selectivity, wide detection
range and low detection limit, which demonstrated an effective tool to detect specific nuc gene
sequences of Staphylococcus aureus.
Method Development and Validation for the Determination of Residual Solvents in Racecadotril by Gas Chromatography
Authors: Sattineni Sirisha Reddy , Joseph Alex , Das Subham , Chaitainya Balusu , Rao Subba 
Published: August 2020

Background:
The presence of residual solvents in pharmaceuticals can be a potential
risk factor to human health because of its toxicity. Gas chromatography is used for its excellent separation
abilities and lower limit of detection. Racecadotril, an antidiarrheal drug, is reported having
four residual solvents, namely n-Hexane, isopropyl alcohol, toluene, and dimethylformamide.
Estimation of the amount of these solvents in active pharmaceutical ingredients to ensure that they
are within the permissible limits as per ICH guidelines is necessary.

Objective:
To develop and validate a new, simple, and sensitive gas chromatographic method for simultaneous
determination of n-Hexane, isopropyl alcohol, toluene, and dimethylformamide in racecadotril.

Methods:
The residual solvents of racecadotril were estimated using a gas chromatographic
method by direct injection using FID as a detector. This method employed a 30-meter long DB-FFAP
nitroterephthalic-acid-modified polyethene glycol column with 0.53 mm in inner diameter
and 1 μm film thickness. The separation was achieved using nitrogen as the carrier gas at a flow
rate of 2.8 mL/min using a split ratio of 1:10.

Results:
The peak shape for all the residual solvents from racecadotril was symmetric with excellent
resolution eluting at reasonable retention time. The limit of detection of n-Hexane, isopropyl alcohol,
Toluene, and dimethylformamide was found to be 6, 27, 14, and 42 ppm, respectively. The
developed method exhibited excellent linearity for each residual solvents in the range studied.

Conclusion:
The developed gas chromatographic method is simple, specific, precise, accurate, and
sensitive. Hence, the method can be successfully used in in the pharmaceutical companies and research
laboratories for simultaneous determination of residual solvents in racecadotril active pharmaceutical
ingredients.
Incentives for Multimodal Treatment-first Step Towards Pay for Quality (P4Q) for Chronic Care: Health Services Research from Germany
Authors: Romeyke Tobias , Noehammer Elisabeth , Stummer Harald 
Published: August 2020

Background: Pay for Quality (P4Q) is being discussed as an incentive to ensure high quality standards despite cost pressure in healthcare. However, P4Q can also have adverse effects, and the evidence for its effectiveness is limited, especially regarding chronic conditions and multimorbidity. For the treatment of the latter, specific evaluation criteria were defined. Whether these are feasible in the context of costs and remunerations is analyzed in this study using the German DRG system as an example. The aim is to show conditions under which P4Q can be effective.

Methods and Results: Costs and remuneration for hospitals were compared for an exemplary geriatric indication, with and without complex treatment. Doing so, cost weights were shown to be more than triple for the latter. The results are applicable to health care systems with P4Q or similar approaches.

Conclusion: Introducing complex treatments poses higher and costly demands regarding structure, processes, and interdisciplinary cooperation in organizations. Additional average costs can be calculated by comparison to regular treatment. Covering the extra costs creates the necessary conditions for P4Q and makes the implementation of complex treatments more likely. As high standards have to be guaranteed for complex treatments and patient satisfaction rises when these are introduced, quality improvements can be assumed. This study can inform Health policy (incentive models) medical societies, give impulses for quality management, and healthcare research (patient-oriented health, e.g. consumer-driven health care, shared decision-making). Future studies should report patient-related outcomes and investigate further diagnoses.
Effect of Fe Substitution on Dielectric, Electrical and Photocatalytic Behavior of ZnO Nanoparticles
Authors: Gawas Umesh B. , Pednekar Rajesh M. , Kothawale Manoj M. , Prasad Nand K. , Alla Santosh K. 
Published: August 2020

Aims:
To develop a simple and cost effective synthetic strategy for the preparation of Fe
substituted ZnO nanoparticles.

Background:
The optoelectronic, electrical, dielectric, optical and magnetic properties of nanocrystalline
transition metal substituted ZnO are being explored worldwide for a variety of applications in
optoelectronic devices, solar cells, transparent thin film transistors, ultraviolet photodetector, piezoelectric
devices, light emitting diodes as well as in the biomedical field. Fe substituted ZnO nanoparticles
are being looked upon as promising material in dilute magnetic semiconductor system.

Objective:
To establish chemical identity and purity in order to ensure the complete substitution of
Fe3+ in ZnO lattice and study the effect of Fe substitution on dielectric, electrical and photocatalytic
behavior of ZnO nanoparticles.

Methods:
The nearly spherical ZnO and Fe substituted ZnO nanoparticles were synthesized at a low
temperature via solution combustion synthesis employing metal nitrate and sucrose.

Results:
The powder X-ray diffraction measurement has revealed the monophasic character and complete
substitution of Fe in the wurtzitic ZnO lattice. The lattice constants and aspect ratio of Fe substituted
ZnO were nearly constant and comparable to that of pristine ZnO. The average crystallite
size was found to decrease with increasing Fe substitution. SEM images revealed porous spongy
network like morphology. TEM measurements revealed a nearly spherical particle with narrow size
distribution between 10 nm - 25 nm.

Conclusion:
The dielectric constant and dielectric loss decrease upto x = 0.04 and increases with further
increase in Fe concentration. The lower value of dielectric loss in the higher frequency region
indicates the less lossy nature of Fe substituted samples. AC conductivity behaviour suggests small
polaron hopping type of conduction mechanism. The RT DC resistivity was found to decrease with
increasing Fe substitution. Pristine ZnO displayed very high degradation efficiency for photodegradation
of MB dye. The photodegradation efficiency was found to decrease considerably with increasing
Fe substitution.
Measuring Asymptomatic Growth of COVID-19; A Powerful Mechanism for Controlling the Disease Spread
Authors: Lau Keith 
Published: August 2020

Background::
Coronavirus, called as, “the worst public health crisis for a generation,” is a
malevolent silent killer.

Objective::
One of the main concerns is containing the disease and avoiding the second wave of the pandemic,
likely to arise because of the symptomatic patients, while ensuring the safe execution of day to
day tasks.

Methods:
The indirect transmission of coronavirus from asymptomatic individuals during incubation
time and the identification of the people who have accidentally and unknowingly come in contact with
infected but asymptomatic patients pose a significant challenge to the health care providers.

Result::
Herein, for the first time, we have introduced a quantitative index; asymptomatic growth, to
indicate whether the COVID-19 community spread is under control and if economic activities can be
resumed.

Conclusion::
More importantly, our system provides a feasible mechanism for improving the index to a
level <1, a safety level at which normal economic activities can be conducted.
Qualidade de vida em diabéticos assistidos em Estratégia de Saúde da Família na região metropolitana de Porto Alegre, RS, Brasil
Authors: Brum Ferraz Etiane , Cechetto Fátima Helena , Riegel Fernando 
Published: August 2020

Objetivo: Avaliar a qualidade de vida (QV) de pacientes diabéticos utilizando o instrumento Medical Outcomes Study 36-item Short Form Health Survey (SF-36). Métodos: estudo quantitativo, transversal e descritivo, realizado com 98 pacientes diabéticos assistidos em uma Estratégia de Saúde da Família da região metropolitana de Porto Alegre, Brasil, por meio de questionário sociodemográfico e do SF-36. Resultados: 59 (60,2%) eram do sexo feminino e a faixa etária entre 50 e 69 anos correspondia a 46,9% da amostra. O diabetes mellitus tipo 2 foi o mais prevalente (68,4%) e a maioria (80,6%) fazia uso exclusivo de hipoglicemiantes orais. As médias dos domínios do SF-36 variaram entre 42,6 ± 44,9(Limitação por Aspectos Físicos) e 70,0 ± 30,1 (Aspectos Sociais). Os diabéticos participantes de atividade educativa apresentaram melhores escores de QV no domínio Dor (61,2 ± 24,8 vs. 45,4 ± 26,2; p = 0,015). Conclusão: os escores do SF-36 apresentaram-se medianos, sugerindo influência negativa do diabetes na qualidade de vida dos participantes. As atividades educativas em grupo mostraram-se associadas a pontuações médias mais elevados dos domínios do escore de QV.
Information Needs About Cancer Treatment, Fertility, and Pregnancy: Qualitative Descriptive Study of Reddit Threads
Authors: Garg Ria , Rebić Nevena , De Vera Mary A 
Published: August 2020

BackgroundA reproductive health implication of the increasing incidence of cancer among women is the impact of cancer treatment on fertility.ObjectiveAs patients are increasingly using the internet, particularly online forums, to seek and share experiences, our objective was to understand information needs about cancer treatment, fertility, and pregnancy of women with cancer as well as their caregivers.MethodsWe searched threads (original posts and responses) on four subreddit sites of Reddit (“r/Cancer,” “r/TryingForABaby,” “r/BabyBumps,” and “r/Infertility”) over a 5‐year period between February 4th, 2014 and February 4th, 2019. Threads with original posts involving a lived experience or question regarding cancer treatment and female fertility and/or pregnancy or parenting/having children from the perspective of either patient or caregiver were included in our analysis. We analyzed threads using thematic analysis.ResultsFrom 963 Reddit threads identified, 69 were analyzed, including 56 with original posts by women with cancer and 13 with original posts by caregivers. From threads made by patients, we identified themes on becoming a part of an online community, impacts of cancer treatment and fertility concerns on self and social relationships, making family planning decisions, and experiences with medical team. We also identified a theme on the impact of cancer treatment and fertility concerns on caregivers.ConclusionsReddit provided a rich pool of data for analyzing the information needs of women facing cancer. Our findings demonstrate the far-reaching impacts of cancer treatment and fertility on physical, mental, and psychosocial health for both patients and their caregivers.
Evaluating the Relationship Between Fitbit Sleep Data and Self-Reported Mood, Sleep, and Environmental Contextual Factors in Healthy Adults: Pilot Observational Cohort Study
Authors: Thota Darshan 
Published: August 2020

Background
Mental health disorders can disrupt a person’s sleep, resulting in lower quality of life. Early identification and referral to mental health services are critical for active duty service members returning from forward-deployed missions. Although technologies like wearable computing devices have the potential to help address this problem, research on the role of technologies like Fitbit in mental health services is in its infancy.

Objective
If Fitbit proves to be an appropriate clinical tool in a military setting, it could provide potential cost savings, improve clinician access to patient data, and create real-time treatment options for the greater active duty service member population. The purpose of this study was to determine if the Fitbit device can be used to identify indicators of mental health disorders by measuring the relationship between Fitbit sleep data, self-reported mood, and environmental contextual factors that may disrupt sleep.

Methods
This observational cohort study was conducted at the Madigan Army Medical Center. The study included 17 healthy adults who wore a Fitbit Flex for 2 weeks and completed a daily self-reported mood and sleep log. Daily Fitbit data were obtained for each participant. Contextual factors were collected with interim and postintervention surveys. This study had 3 specific aims: (1) Determine the correlation between daily Fitbit sleep data and daily self-reported sleep, (2) Determine the correlation between number of waking events and self-reported mood, and (3) Explore the qualitative relationships between Fitbit waking events and self-reported contextual factors for sleep.

Results
There was no significant difference in the scores for the pre-intevention Pittsburg Sleep Quality Index (PSQI; mean 5.88 points, SD 3.71 points) and postintervention PSQI (mean 5.33 points, SD 2.83 points). The Wilcoxon signed-ranks test showed that the difference between the pre-intervention PSQI and postintervention PSQI survey data was not statistically significant (Z=0.751, P=.05). The Spearman correlation between Fitbit sleep time and self-reported sleep time was moderate (r=0.643, P=.005). The Spearman correlation between number of waking events and self-reported mood was weak (r=0.354, P=.163). Top contextual factors disrupting sleep were “pain,” “noises,” and “worries.” A subanalysis of participants reporting “worries” found evidence of potential stress resilience and outliers in waking events.

Conclusions
Findings contribute valuable evidence on the strength of the Fitbit Flex device as a proxy that is consistent with self-reported sleep data. Mood data alone do not predict number of waking events. Mood and Fitbit data combined with further screening tools may be able to identify markers of underlying mental health disease.
Asynchronous mHealth Interventions in Rheumatoid Arthritis: Systematic Scoping Review
Authors: Seppen Bart F , den Boer Pim , Wiegel Jimmy , ter Wee Marieke M , van der Leeden Marike , de Vries Ralph , van der Esch Martin , Bos Wouter H 
Published: August 2020

Background
Mobile devices such as smartphones and tablets have surged in popularity in recent years, generating numerous possibilities for their use in health care as mobile health (mHealth) tools. One advantage of mHealth is that it can be provided asynchronously, signifying that health care providers and patients are not communicating in real time. The integration of asynchronous mHealth into daily clinical practice might therefore help to make health care more efficient for patients with rheumatoid arthritis (RA). The benefits have been reviewed in various medical conditions, such as diabetes and asthma, with promising results. However, to date, it is unclear what evidence exists for the use of asynchronous mHealth in the field of RA.

Objective
The objective of this study was to map the different asynchronous mHealth interventions tested in clinical trials in patients with RA and to summarize the effects of the interventions.

Methods
A systematic search of Pubmed, Scopus, Cochrane, and PsycINFO was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies were initially screened and later assessed by two independent researchers. Disagreements on inclusion or exclusion of studies were resolved by discussion.

Results
The literature search yielded 1752 abstracts. After deduplication and screening, 10 controlled intervention studies were included. All studies were assessed to be at risk for bias in at least one domain of the Cochrane risk-of-bias tool. In the 10 selected studies, 4 different types of mHealth interventions were used: SMS reminders (to increase medication adherence or physical activity; n=3), web apps (for disease monitoring and/or to provide medical information; n=5), smartphone apps (for disease monitoring; n=1), and pedometers (to increase and track steps; n=1). Measured outcomes varied widely between studies; improvements were seen in terms of medication compliance (SMS reminders), reaching rapid remission (web app), various domains of physical activity (pedometer, SMS reminders, and web apps), patient-physician interaction (web apps), and self-efficacy (smartphone app).

Conclusions
SMS reminders, web apps, smartphone apps, and pedometers have been evaluated in intervention studies in patients with RA. These interventions have been used to monitor patients or to support them in their health behavior. The use of asynchronous mHealth led to desirable outcomes in nearly all studies. However, since all studies were at risk of bias and methods used were very heterogeneous, high-quality research is warranted to corroborate these promising results.
Association Between Usage of an App to Redeem Prescribed Food Benefits and Redemption Behaviors Among the Special Supplemental Nutrition Program for Women, Infants, and Children Participants: Cross-Sectional Study
Authors: Zhang Qi , Zhang Junzhou , Park Kayoung , Tang Chuanyi 
Published: August 2020

Background
The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is one of the most important food assistance programs in the United States, serving 6.4 million low-income, eligible women, infants, and children under 5 years of age in 2019. In the program, participants are prescribed a list of food benefits, which can be redeemed in WIC-authorized stores. However, there are multiple behavioral barriers in the program and the stores that prevent participants from redeeming the benefits fully.

Objective
This study aims to examine the relationship between the use of a widely used mobile phone app, WICShopper, and the redemption of the prescribed food packages.

Methods
WIC administrative data were obtained from West Virginia for the period January 2019 to January 2020 and included 30,440 WIC households that had received food benefits in that period. The redemption rates of 18 WIC food benefits were compared between app users and nonapp users, that is, those who never used the app in the study period. The use behaviors were defined for the app users, including the number of active use benefit cycles, active benefit cycle rates, number of active use days in the cycle, and proportion rates of daytime use. Panel linear regressions were applied to examine how the redemption rates were related to these behaviors over time.

Results
App users consistently had higher average redemption rates than nonapp users; the difference ranged from 3.6% (4.8% relative) for infant formula to 14.3% (40.7% relative) for fish. After controlling for sociodemographics, the coefficients of app use were significantly positive for all benefit categories except for WIC-eligible nutritionals. More active cycles and active days in the cycle were significantly related to redemption rates for all categories, except for frozen juice (coefficient=−0.002, P=.09). Daytime app access was positively associated with redemption rates for most food benefits except only a few, such as infant formula (coefficient=−0.03, P<.001).

Conclusions
Use of the WIC app was significantly related to higher redemption rates across food benefits, although the association varied across benefit categories. More active days were positively related to benefit redemptions across food categories, and the app’s daytime use was positively associated with the redemption of most benefit categories. These findings suggest that the WIC app can be an important tool for the promotion of benefit redemption among WIC participants.