bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Network Polypharmacological Approach to Combinatorial Drug Repurposing for Diffuse Intrinsic Pontine Glioma
Authors: MacLean Finlay , Nazarian Javad , Przystal Justyna , Pantziarka Pan , Wilson Jabe 
Published: June 2020

AbstractDespite five decades of clinical investigations, there is currently no effective treatment for children diagnosed with Diffuse Intrinsic Pontine Glioma (DIPG). We now understand that DIPGs share the same histone 3 mutation and fatal prognosis as other diffuse midline gliomas (DMGs), which led to the introduction of a new entity referred to as DMG, H3 K27M mutant. Indeed, therapeutics indicated for other brain neoplasms have proven ineffective for DIPGs. We posit that by using a polypharmacological approach to determine drug combinations that target distinct mechanistic pathways of DIPG, it is more likely that an efficacious treatment will be developed. We predict monodrug therapies using a link prediction model trained on various embeddings of a drug-disease regulatory network and physicochemical properties of small molecules and proteins. We validate thein silicopredictions by performing cell viability assays on patient-derived cell cultures for notable therapeutics. Using FDA-approved drugs as a proxy for viability of a drug pair for combinatorial use, we develop a model to predict the synergism of the relationship between drug pairs. Finally, we calculate the transitive probability that a drug pair contains drugs that individually regulate DIPG, are blood-brain barrier penetrant, and the drug pair are suitable for combined use. We find only moderate agreement between computational predictions and experimental results for both monodrug and multidrug therapies, we believe due to the heterogeneity of the disease, the difficulties of modelling brain permeability, and an inherent literature bias in the knowledge graph. Such challenges need to be overcome to develop an efficacious therapy for this disease.
Anopheles coluzziistearoyl-CoA desaturase is essential for adult female survival and reproduction upon blood feeding
Authors: Ferdous Zannatul , Fuchs Silke , Behrends Volker , Trasanidis Nikolaos , Vlachou Dina , Christophides George K. 
Published: June 2020

AbstractVitellogenesis and oocyte maturation require anautogenous femaleAnophelesmosquitoes to obtain a bloodmeal from a vertebrate host. The bloodmeal is rich in proteins that are readily broken down into amino acids in the midgut lumen and absorbed by the midgut epithelial cells where they are converted into lipids and then transported to other tissues including ovaries. The stearoyl-CoA desaturase (SCD) plays a pivotal role in this process by converting saturated (SFAs) to unsaturated (UFAs) fatty acids; the latter being essential for maintaining cell membrane fluidity amongst other housekeeping functions. Here, we report the functional and phenotypic characterization of SCD1 in the malaria vector mosquitoAnopheles coluzzii. We show that RNA interference (RNAi) silencing ofSCD1and administration of sterculic acid (SA), a small molecule inhibitor of SCD1, significantly impact on the survival and reproduction of female mosquitoes following blood feeding. Microscopic observations reveal that the mosquito thorax is quickly filled with blood, a phenomenon likely caused by the collapse of midgut epithelial cell membranes, and that epithelial cells are depleted of lipid droplets and oocytes fail to mature. Transcriptional profiling shows that genes involved in protein, lipid and carbohydrate metabolism and immunity-related genes are the most affected bySCD1knock down (KD) in blood-fed mosquitoes. Metabolic profiling reveals that these mosquitoes exhibit increased amounts of saturated fatty acids and TCA cycle intermediates, highlighting the biochemical framework by which theSCD1KD phenotype manifests as a result of a detrimental metabolic syndrome. Accumulation of SFAs is also the likely cause of the potent immune response observed in the absence of infection, which resembles an auto-inflammatory condition. These data provide insights into mosquito bloodmeal metabolism and lipid homeostasis and could inform efforts to develop novel interventions against mosquito-borne diseases.
Economic policy uncertainty and firms' labor investment decision
Authors: Chu Jian , Fang Junxiong 
Published: June 2020

PurposeThe purpose of this paper is to empirically investigate the impact of economic policy uncertainty on firms' labor investment decision, which includes labor investment level and efficiency, especially human capital allocation.Design/methodology/approachThis paper uses Economic Policy Uncertainty Index for China and Chinese A-share listed firms in the period 2002–2016 to constructs a sample of 20,779 firm-year observations and applies the methods of pooled OLS regressions to do an empirical study.FindingsThis paper finds that firms' labor investment is negatively correlated with economic policy uncertainty. And firms' labor investment efficiency (and overinvestment in labor) is positively (negatively) correlated with economic policy uncertainty, which is more significant for non-SOEs and firms with less government intervention. Further, the positive relation between economic policy uncertainty and labor investment efficiency is more significant for labor-intensive firms, firms in competitive industry, firms in developed labor market and firms under strong labor law protection. In addition, economic policy uncertainty induces firms to make adjustment on human capital structure and allocate more employees with high human capital, which eventually helps firms achieve higher total factor productivity.Social implicationsThe study of this paper indicates that the government needs to consider economic policies' impact on firms when introducing and changing policies and guide firms to improve human capital allocation under different internal and external conditions to finally realize the optimal allocation of social resources.Originality/valueThis paper studies the influence of external economic policy environment on firms' labor investment decision, which lacks adequate attention in the literature and indicates that under economic policy uncertainty, firms actively decrease labor demand and increase labor investment efficiency by optimizing human capital allocation.
What national governance codes say about corporate culture
Authors: Lobrij Marie-Fleur , Kaptein Muel , Lückerath-Rovers Mijntje 
Published: June 2020

PurposeThis study aims to provide insight into the current incorporation of corporate culture in national corporate governance codes. The authors identify three levels of incorporation for each of the following three dimensions: layers of corporate culture (the “what”), the alignment of corporate culture in the organization (the “for whom”) and the board’s roles regarding corporate culture (the “how”).Design/methodology/approachTo assess the extent to which national codes have incorporated corporate culture, the authors used a sample of 88 national corporate governance codes. The authors performed a content analysis of these codes using a computer-aided text analysis program. The first step involved the identification of dimensions of corporate culture per national code. These dimensions were then assessed based on three levels of incorporation. Finally, the authors ranked national codes with similar levels of incorporation per dimension and aggregated the dimensions.FindingsThe data show that five of the 88 national corporate governance codes that the authors analysed scored the highest level in all three dimensions of corporate culture.Originality/valueThis is the first study to provide an overview of what national corporate governance codes say about corporate culture. The authors address two gaps in the existing literature. First, the authors develop and use a richer conceptualization of how corporate culture can be addressed in national corporate governance codes. Second, the authors analyse these corporate governance codes worldwide.
From cultural differences to cultural globalization: towards a new research agenda in cross-cultural management studies
Authors: Boussebaa Mehdi 
Published: June 2020

Purpose
This paper responds to calls for a new raison d’être in the field cross-cultural management (CCM) and culture-sensitive studies of international business (IB) more broadly. It argues that one way of addressing the crisis of confidence in the field is to develop a line of inquiry focussed on corporate-driven cultural globalization. This paper also proposes a theoretical approach informed by international political economy (IPE) and postcolonial theory and outlines a research agenda for future work on cultural globalization.

Design/methodology/approach
The paper is a desk-based analysis that draws on relevant research in the wider social sciences to insert cultural globalization into the CCM/IB field’s intellectual project.

Findings
The paper finds the field of CCM and culture-sensitive IB studies more broadly to be almost exclusively focussed on studying the impact of cultural differences. Surprisingly, little attention has been devoted to the phenomenon of corporate-driven cultural globalization.

Research limitations/implications
The paper redirects the field and presents a research agenda, calling for studies on the role of four related actors in cultural globalization: MNEs, global professional service firms, business schools and CCM/IB researchers themselves.

Practical implications
CCM/IB scholars may be able to reorient themselves towards the phenomenon of cultural globalization and, in so doing, also seize an opportunity to contribute to important debates about it in the wider social sciences.

Originality/value
The paper suggests possibilities for renewal by redirecting CCM/IB towards the study of cultural globalization and by encouraging the field to develop a postcolonial sensibility in future research on the phenomenon.
Gift giving via social network services: the case of a WeChat mini-program used in China
Authors: Hao Chen , Hai-tao Chen 
Published: June 2020

PurposeThe purpose of this paper is to examine and explore the factors that drive users to gift through social network services (SNS).Design/methodology/approachA questionnaire method was applied to collect data from the sample of the WeChat users who have used mini-program. This paper employed the partial least squares method and used SmartPLS2.0 to analysis sample data, which examined the validity as well as reliability of the sample and further tested the hypotheses by the path coefficients.FindingsThe empirical results showed that pleasure, social relationship maintenance, convenience and comprehensiveness are significantly related to SNS gifting behavior, and conscientiousness moderates the relationship between intention and behavior in the context of SNS gifting. However, this study cannot find the effect of symbolic representation, impersonality and gift reciprocity motivations.Research limitations/implicationsTheoretically, this study perfects the research of SNS gifting on the lack of exploring characteristics of comprehensiveness. Practically, this paper lends insights on how SNS providers attract users to adopt gifting.Originality/valueSNS gifting lacks a complete and effective promotion strategy, resulting in a small number of users as well as low profit. Besides, prior studies have focused on tradition gifting and online gifting. Little research talks about gifting on SNS phenomena, and thus it is necessary to perfect the theory of SNS gifting.
Cultural intelligence and innovative work behavior: the role of work engagement and interpersonal trust
Authors: Afsar Bilal , Al-Ghazali Basheer M. , Cheema Sadia , Javed Farheen 
Published: June 2020

PurposeBecause of the rapidly changing environment and fleeting market opportunities, employee's innovative work behavior is increasingly assuming a pivotal role in enhancing organizational effectiveness and competitive advantage. The success of organizations is largely depended on their employees' ability to innovate. The role of cultural intelligence to enhance innovative work behavior is yet to be explored in the innovation research. The purpose of this study is to examine how cultural intelligence enhances employees' innovative work behavior through work engagement and interpersonal trust.Design/methodology/approachThe study is a cross-sectional design which utilizes data from 381 participants from multinational corporations in Saudi Arabia.FindingsThe results indicate that cultural intelligence can significantly affect employee's innovative work behavior. It further reveals that both work engagement and interpersonal trust partially mediate the effect of cultural intelligence on innovative work behavior.Originality/valueThis study adds to the literature on intelligence by examining an underexplored type of intelligence (i.e. cultural intelligence) in relation to employee's innovative work behavior. It reveals work engagement and interpersonal trust as the psychological mechanisms that can link cultural intelligence to innovative work behaviors.
A study of the influence of workplace ostracism on employees' performance: moderating effect of perceived organizational support
Authors: Choi Youngkeun 
Published: June 2020

PurposeBased on the conservation of resource theory, this study developed and tested the relationship between workplace ostracism and job performance. And it assumes that the direct link between workplace ostracism and supervisor-rated in-role performance/organizational citizenship behavior is moderated by perceived organizational support.Design/methodology/approachFor this, this study used a survey method and multiple regression analyses with multisource data from 256 Korean employees and their supervisors.FindingsThe results suggest the following. First, workplace ostracism was negatively associated with supervisor-rated in-role performance and organizational citizenship behaviors. Second, there was a stronger negative relationship between workplace ostracism and supervisor-rated in-role performance/organizational citizenship behaviors for employees with low as opposed to those with high levels of perceived organizational support.Originality/valueThis study is the first one to examine the moderating effect of perceived organizational support on the relationship between workplace ostracism and supervisor-rated in-role performance/organizational citizenship behavior.
Gender makes the difference: the moderating role of gender on the relationship between management structure and performance in banking
Authors: Stefanovic Nikola , Barjaktarovic Lidija 
Published: June 2020

Purpose
This study aims to explore the factors moderating possibly indirect relationships between gender diversity and its effect on bank performance. The causality of this relationship remains unclear.

Design/methodology/approach
The sample consists of all banks (n = 27) operating in Serbia.

Findings
The gender diversity-performance relationship is indirect. The gender diversity of executive boards positively impacts bank performance, over a threshold level. This is observed only in banks where gender diversity is extended to more than one level of executive authority.

Research limitations/implications
Gender diversity should be fostered, particularly in small and competitive markets. The gender diversity-performance link is based on gender-related social interactions, which are interdependent and should not be taken into account as isolated factors.

Originality/value
To the knowledge, this is the first study to provide insight into indirect, gender related, moderatory interactions effecting gender diversity – performance link, in banking.
Public health spending and health outcome in Nigeria: the role of governance
Authors: Osakede Uche Abamba 
Published: June 2020

Purpose
This paper aims to analyze the relationship between public health spending and health outcome using time series data in Nigeria over the period 1980 to 2017, taking into account the role of governance by assessing how the quality of governance directly affects health status and indirectly as a mediator for the effectiveness of public health spending.

Design/methodology/approach
Using the Hausman statistical tests to check for the existence of endogeneity, the proper method for estimating the model for this study is the two-stage least square regression model. The two-stage least squares regression model addresses the problem of endogeneity using instrumental variables. The mediating role of governance on the effectiveness of public health spending on health was considered by an interaction of governance indicators with public health spending.

Findings
The results showed that public health spending had no significant effect on health outcome except when interacted with governance quality. The interaction of government health spending with governance effectiveness as well as that for control of corruption improved health by inducing a fall in maternal deaths, whereas government health expenditure interacted with rule of law raised maternal mortality. Public health spending interacted with regulatory quality improved life expectancy while that for political stability with public health spending induced a fall in life expectancy, poor maternal and infant health. Political stability and the control of corruption had direct influence on maternal health.

Practical implications
Given the predominance of public health spending in promoting access to health care and population health status for developing economies, the effectiveness of such spending should be top priority in policy makers’ agenda. This again is important because for developing economies, government revenue is generated from a small tax base due to their highly informal nature. To improve health status from public intervention in the health sector, there is indeed need for improvement in the overall state of governance in Nigeria.

Originality/value
This paper is one of the few country case studies which uses time series data to examine the role of governance on the efficacy of public health spending with extension of findings to maternal health and covering more measures of governance quality. The results fundamentally illuminate the importance of governance in fostering development in health and consequently enhancing economic development and growth.
Potential for waste to energy generation of municipal solid waste (MSW) in the Kumasi metropolis of Ghana
Authors: Amo-Asamoah Eugene , Owusu-Manu De-Graft , Asumadu George , Ghansah Frank Ato , Edwards David John 
Published: June 2020

Purpose
Globally, waste management has been a topical issue in the past few decades due to the continual increase in municipal solid waste (MSW) generation that is becoming difficult to handle with conventional waste management techniques. The situation is much more pronounced in economically developing countries where population growth rate and urbanisation are becoming uncontrollable. The purpose of this study was to assess the potential for waste to energy generation in the Kumasi metropolis, the second-largest city in Ghana.

Design/methodology/approach
To address the objectives of the study, a quantitative research approach, namely, the questionnaire was adopted. The data analysis was done using the statistical package for social sciences version 25, including both descriptive and inferential statistics to give an in-depth meaning to the responses from the participants.

Findings
The results showed that several factors hinder waste to energy technology in Ghana; key among them was high capital cost, high operational cost and lack of governmental support and policy framework. The results also revealed that 1 m3 of biogas generated from MSW in Kumasi could generate 36 MJ of energy, equivalent to 10 kW/h.

Originality/value
The unique contribution made by the paper is that it combines expert opinions, empirical data that included time series data and opinion of key actors in the waste management chain in assessing the potential for waste to energy generation in the Kumasi metropolis of Ghana.
The long-run performance of SME IPOs in India: empirical evidence from Indian stock market
Authors: Arora Nischay , Singh Balwinder 
Published: June 2020

Purpose
The purpose of this paper is to study the pattern of long-run performance of small and medium enterprises (SMEs) initial public offerings (IPOs) and examine the firm- and issue-related determinants of long-run performance of SME IPOs in India.

Design/methodology/approach
The 3 6, 9 and 12 months share returns of Indian SME IPOs is studied using event time methodologies, i.e. buy and hold returns, cumulative abnormal returns and wealth relatives on a sample of 375 SME IPOs issued during February 2012 to May 2018. Additionally, ordinary least square regression has been used to investigate the determinants of long-run performance of SME IPOs on a reduced sample of 104 because of non-availability of price observations.

Findings
The findings reveal that Indian SME IPOs exhibit long-run overperformance contradicting the international evidences of underperformance, and this overperformance is significantly evident using buy and hold abnormal return (BHAR). Furthermore, based on the divergence of opinion hypothesis, fads theory and windows of opportunity hypothesis, the results reveal that on one hand, issue size and oversubscription negatively affect BHAR, while on the other hand, auditor reputation, underwriter reputation, hot market, underpricing, inverse of issue price, profits prior to listing positively affect long-run performance. However, firm age, firm size, debt equity ratio, volatility and long-run performance computed through BHAR lacks significant relationship.

Research limitations/implications
The study relied on event time methodology of measuring aftermarket performance of one year because of the limited availability of price offerings. Hence, the study could be extended to analyze aftermarket returns over a period of three to five years to enable reaching the vivid conclusions. Calendar time methodology may also be used to compute abnormal returns.

Practical implications
The results based on the study provides an implication to the investors by providing them an opportunity to bank higher long-run returns by engaging in active and timely trading strategies. Nevertheless, the results also show that investors should be cautioned while taking investment decisions.

Originality/value
The study contributes to rising body of international literature by analyzing the larger and recent sample of IPOs issued from 2012 to 2018 listed on SME exchange.
Rural health enterprises in the EU context: a systematic literature review and research agenda
Authors: Apostolopoulos Nikolaos , Ratten Vanessa , Stavroyiannis Stavros , Makris Ilias , Apostolopoulos Sotiris , Liargovas Panagiotis 
Published: June 2020

Purpose
The COVID-19 crisis has brought to the forefront the importance of rural health enterprises (RHEs), the peculiarity, in these terms, of rural areas, and the impact of rurality on health entrepreneurial activities. This paper aims to undertake a literature review regarding RHEs in the EU, identify research gaps and set future research directions.

Design/methodology/approach
A systematic literature review was conducted and the key aspects coded across four thematic areas – after examining 68 papers.

Findings
The findings reveal that more intense research should be conducted across four area which emerged; rural health providers vs urban health providers; RHEs and rural development; RHEs and quality of life; and social RHEs.

Research limitations/implications
Future research avenues were identified and suggestions for further research on RHEs were provided.

Practical implications
The paper provides insights into how rural areas can attract health enterprises and how health enterprises can operate in rural areas.

Originality/value
This research expands on the limited existing knowledge of RHEs and sets the foundations for further research.