bluuebunny/crossref_metadata_2025_split huggingface dataset:
Executive function in XXY: Comparison of performance‐based measures and rating scales
Authors: Janusz Jennifer , Harrison Caroline , Boada Cristina , Cordeiro Lisa , Howell Susan , Tartaglia Nicole , Boada Richard 
Published: June 2020

AbstractFew studies have systematically assessed executive functioning (EF) skills in boys with XXY, and these are limited by small samples and restricted EF assessment. This study used a broader battery of performance‐based measures as well as parent‐rating scales of EF in 77 boys and adolescents with XXY (mean age = 12.5 years), recruited from a clinical trial and an outpatient clinic. Exploratory factor analyses were used to create EF domains from performance‐based measures, and similar domains were measured using the Behavior Rating Inventory of Executive Function and Conners Parent‐Rating Scales. The boys with XXY showed a distinct EF profile, with the greatest deficit in attention and more moderate deficits in working memory, switching, and planning/problem solving. Parent ratings showed similar challenges, as well as impaired inhibition. Independent sample t‐tests showed no difference on performance measures between boys diagnosed or not diagnosed with attention‐deficit/hyperactivity disorder (ADHD), although parents of boys diagnosed with ADHD reported more difficulties. There were no differences on performance‐based tests between those diagnosed pre‐ and postnatally, although parents of postnatally diagnosed boys reported more metacognitive problems. Language deficits, cognition, and socio‐economic status did not account for EF deficits.
A high‐efficiency novel IGCC‐OTM carbon capture power plant design
Authors: Wu Xiao‐Yu , Cai Lili , Zhu Xuefeng , Ghoniem Ahmed F. , Yang Weishen 
Published: June 2020

AbstractCoal power plants play an important role in supplying affordable and reliable electricity. It is necessary to develop high‐efficiency and low‐cost carbon capture (CC) technologies to mitigate the associated global warming. Using H2S‐tolerant oxygen transport membranes (OTMs) for hydrogen production and CO2 separation can significantly reduce the energy penalty of CC in integrated gasification combined cycle (IGCC) power plants. We carried out system‐level analysis to investigate a novel IGCC‐CC power plant design using OTMs. We studied the impacts of various operating parameters on the overall efficiency and energy penalty. This novel IGCC‐OTM system has an overall efficiency 3.2%‐point lower than the same system without CC, much lower than the IGCC with water‐gas shift reactors and acid gas removal units (IGCC‐WGS) of 6.8%‐point drop. The specific primary energy consumption for CO2 avoided (SPECCA) of this novel technology is 1.08 MJ kgCO2−1, which is 59.4% lower than that of the IGCC‐WGS.
CRISPR Mediated Biosensing Toward Understanding Cellular Biology and Point‐of‐Care Diagnosis
Authors: Dai Yifan , Wu Yanfang , Liu Guozhen , Gooding J. Justin 
Published: June 2020

AbstractRecent advances in CRISPR based biotechnologies have greatly expanded our capabilities to repurpose CRISPR for the development of biomolecular sensors for diagnosing diseases and understanding cellular pathways. The key attribute that allows CRISPR to be widely utilized is the programmable and highly selective mechanism. In this Minireview, we first illustrate the molecular principle of CRISPR functioning process from sensing to actuating. Next, the CRISPR based biosensing strategies for nucleic acids, proteins and small molecules are summarized. We highlight some of recent advances in applications for in vitro detection of biomolecules and in vivo imaging of cellular networks. Finally, the challenges with, and exciting prospects of, CRISPR based biosensing developments are discussed.
Self‐Healing Supramolecular Materials Constructed by Copolymerization via Molecular Recognition of Cavitand‐Based Coordination Capsules
Authors: Nitta Natsumi , Takatsuka Mei , Kihara Shin‐ichi , Hirao Takehiro , Haino Takeharu 
Published: June 2020

AbstractThe repeating guest units of poly‐(R)‐2 were selectively encapsulated by the self‐assembled capsule poly‐1 possessing eight polymer side chains to form the supramolecular graft polymer (poly‐1)n⋅poly‐(R)‐2. The encapsulation of the guest units was confirmed by 1H NMR spectroscopy and the DOSY technique. The hydrodynamic radius of the graft polymer structure was greatly increased upon the complexation of poly‐1. The supramolecular graft polymer (poly‐1)n⋅poly‐(R)‐2 was stably formed in the 1:1 host–guest ratio, which increased the glass transition temperature by more than 10 °C compared to that of poly‐1. AFM visualized that (poly‐1)n⋅poly‐(R)‐2 formed the networked structure on mica. The (poly‐1)n⋅poly‐(R)‐2 gelled in 1,1,2,2‐tetrachloroethane, which led to fabrication of distinct viscoelastic materials that demonstrated self‐healing behavior in a tensile test.
ATP‐Driven Synthetic Supramolecular Assemblies: From ATP as a Template to Fuel
Authors: Mishra Ananya , Dhiman Shikha , George Subi J. 
Published: June 2020

AbstractAdenosine triphosphate (ATP) is a molecular unit of energy that drives various processes in the cellular environment. In this Minireview, we discuss the potential of physical and chemical properties of ATP for the development of bio‐inspired, synthetic ATP‐induced supramolecular systems with dynamic, stimuli‐responsive and active assembly characteristics. Molecular design rules for ATP‐induced assemblies with various architectures and their stimuli‐responsive structural and functional response are categorized. Special attention is given to the immense potential of ATP‐fuelled designs in the nascent field of transient/non‐equilibrium supramolecular polymerization for the synthesis of lifelike temporally programmable soft materials. Finally, the existing dearth and fate of ATP‐driven systems for future challenges are discussed.
Preparation and reshaping of composite microparticles for color toner based on the encapsulated nanoparticles
Authors: Liao Jun , Ye Mingquan , Han Aijun , Chen Xin , Zhang Kui , Guo Jianming , Chen Chenlu 
Published: June 2020

AbstractIn this paper, the styrene–acrylic resin‐encapsulated organic pigment composite nanoparticles were synthesized by mini‐emulsion polymerization first, and then the aggregated microparticles used for color toner were prepared via the emulsion aggregation method. Transmission electron microscopy, dynamic light scattering, and zeta potential analysis manifest that when the emulsifier dosage was 5 wt% of the monomer, the composite nanoparticles owned clearly core‐shell structure, uniform size, and appropriate zeta potential, which was conducive to the subsequent aggregation. The evolution of aggregated particle size and morphology under different stirring rates, coagulant concentrations, and temperatures was investigated by mastersizer and scanning electron microscopy. The result shows that when the stirring rate was 1,000 rpm, coagulant concentration was 0.2 mol/L, and the curing temperature was 65°C, aggregated particles with suitable size, narrow size distribution, and regular shape could be obtained. The reshaping of aggregated particles can further improve their morphology. When the reshaping temperature was 75°C, the product particles owned perfect spherical shape, and there were almost no cracks and pores on the surface of the particles. This synthesis strategy is believed to provide a guide for the fabrication of composite microparticles with controllable particle size and morphology.
Gun to body: Mental health against unchilding
Authors: Shalhoub‐Kevorkian Nadera 
Published: June 2020

AbstractThe paper demarcates the ways children experience and locate their suffering within the colonial violence that dominates their reality. It follows Martín‐Baró's model of articulating a critical psychology “of the people,” (Lykes & Sibley, 2014) while connecting and constructing the author's analysis through the words and reflections of Palestinian children from Jerusalem, Hebron and Gaza. To understand Palestinian children's narrations, the article analyzes (1) how territorial siege, segregation and separation from the homeland constitute, as children in Gaza explained, “non‐breathing,” non‐living spaces, produced by rendering lands, bodies, and lives exterminable and disposable; (2) how securitization and military checkpoints (“killing boxes”) dominate the geography of the neighbourhood, so as to confine children within a condition of “caging” and maintain them as “caged others;” and (3) how the settler colonial governance of childhood invades not only public space with their “killing boxes,” but also the Palestinian home and intimate familial spaces through practices of child home‐arrests. It concludes by illustrating the ways in which children endure ongoing wounding and engage in the process of healing while living under the ideological militarized force of uprootedness and “rightlessness.” Politicizing the examinations, and interventions with children's wounds and traumas, when living and surviving what the article frames as a “gun to body” context, can promote mental health worker's attentiveness to children's performances and transformations, recognizing and affirming the agency of subjects undergoing dispossession and cruel injustice.
Advances in [4+3]‐Annulation/Cycloaddition Reactions Leading to Homo‐ and Heterocycles with Seven‐Membered Rings
Authors: Selvaraj Karuppu , Chauhan Sachin , Sandeep K. , Swamy K. C. Kumara 
Published: June 2020

AbstractIn this review, we summarize advances in [4+3] and a few other annulation/cycloaddition reactions for the construction of seven membered rings, with an emphasis on the literature subsequent to the year 2010. The type of products include the following: azepines, diazepines, benzazepinones, 1,2‐diazepinones, oxazepinones, benzothiazepines, benzodiazepinones, benzoxopinones, cyclohepta[b]indoles, benzoxazepines, azepino‐indoles, oxepines/oxazepanes, triazepines oxepinoindolones/azepinoindolones, oxadiazepines, azabicyclooctanes. Emphasis is also given to cover diverse types of annulations; possible intermediates are displayed in the illustrated schemes to aid future work.
The effect of magnetized water on the oxidation reaction of phenol derivatives and aromatic amines by horseradish peroxidase enzyme
Authors: Emamdadi Narjes , Gholizadeh Mostafa , Housaindokht Mohammad Reza 
Published: June 2020

AbstractThe present study aimed to investigate, for the first time, the rate of the oxidation reaction of some derivatives of phenol and aromatic amines, that is, pyrogallol, catechol, resorcinol, ortho‐aminophenol, meta‐aminophenol, para‐aminophenol, ortho‐phenylenediamine, and para‐phenylenediamine, in the presence of hydrogen peroxide in pure and magnetized solvents using horseradish peroxidase enzyme. The reaction was studied in the absence and presence of a magnetized solvent under completely identical conditions. The results showed that magnetized solvent could change the structure of the enzyme and reduce its activity. In addition, it affected the rate of oxidation of the selected derivatives through altering the strength of the hydrogen bonds of the system. The changes in the structure and activity of the enzyme were examined using UV–Vis and fluorescence spectroscopy as well as viscosity measurement technique. Examination of the secondary structure via the far UV‐CD spectrum indicated the increase in the alpha helical structure in the magnetized solvent. When dissolved in a magnetized solvent, hydrogen peroxide as an enzyme substrate reduced the rate of enzymatic reaction and provided lower saturation conditions for the enzyme compared with when it was dissolved in the pure solvent.
Subarachnoid space trabeculae architecture
Authors: Saboori Parisa 
Published: June 2020

AbstractIntroductionThe motion of the brain relative to the skull is influenced by the architecture of the subarachnoid space (SAS), and in particular, by the arachnoid trabeculae. In previous studies of these structures, specific shapes were identified. However, the work presented here shows much finer detail of the SAS geometries using SEM and TEM.Materials and methodsThese images were acquired by maintaining the SAS structure of a rat using glutaraldehyde formaldehyde to strengthen the tissues via crosslinking with the biological proteins.ResultsThe results showed the detailed shape of five dominant arachnoid trabeculae structures: single strands, branched strands, tree like shapes, sheets, and trabecular networks. Each of these architectures would provide a different response when exposed to a tensile load and would provide different levels of resistance to the flow of the cerebrospinal fluid (CSF) within the SAS.ConclusionThis very detailed level of geometric information will therefore allow more accurate finite element models of the SAS to be developed.
Downregulation of KIAA1199 by miR‐486‐5p suppresses tumorigenesis in lung cancer
Authors: Wang Anqi , Zhu Jianjie , Li Juan , Du Wenwen , Zhang Yang , Cai Tingting , Liu Ting , Fu Yulong , Zeng Yuanyuan , Liu Zeyi , Huang Jian‐an 
Published: June 2020

AbstractLung cancer is the primary cause of death among cancer patients in China, among which nonsmall cell lung cancer (NSCLC) makes up the great majority. Hence, it is imperative to identify the biomarkers and mechanisms involved in NSCLC oncogenesis. Our present research found that KIAA1199 expression was significantly increased in NSCLC and closely related to cell proliferation, motility, and poor prognosis. We demonstrated that knockdown of KIAA1199 reduced NSCLC cell growth and motility in vitro whereas overexpression of KIAA1199 had the opposite effect. Inhibition of KIAA1199 significantly suppressed tumor growth in mouse NSCLC xenograft models. Mechanistically, as an epidermal growth factor receptor (EGFR)‐binding protein, KIAA1199 promotes EGFR signaling and regulates EGFR‐dependent Src, Erk, and Akt phosphorylation, as well as downstream kinases in the EGF‐mediated EMT pathway. We demonstrated that KIAA1199 can function as a direct binding target for miR‐486‐5p and that miR‐486‐5p overexpression can attenuate proliferation and migration of NSCLC cells via regulating the EGFR signaling pathways. To conclude, our results defined KIAA1199 as an oncogenic protein that promotes cancer cell proliferation and migration by regulating EGF‐mediated signaling pathways. This study provided new insight into NSCLC oncogenesis, which could lead to the development of innovative therapeutic plans for NSCLC.
Boron‐Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides
Authors: Bregadze Vladimir I. , Sivaev Igor B. , Dubey Ravindra Dhar , Semioshkin Andrey , Shmal'ko Akim V. , Kosenko Irina D. , Lebedeva Kseniya V. , Mandal Swadhin , Sreejyothi Prasannakumar , Sarkar Arindam , Shen Zheyu , Wu Aiguo , Hosmane Narayan S. 
Published: June 2020

AbstractA series of boron‐containing lipids were prepared by reactions of cyclic oxonium derivatives of polyhedron boranes and metallacarboranes (closo‐dodecaborate anion, cobalt and iron bis(dicarbollides)) with amine and carboxylic acids which are derived from cholesterol. Stable liposomal formulations, on the basis of synthesized boron‐containing lipids, hydrogenated soybean l‐α‐phosphatidylcholine and (HSPC) 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycol)‐2000] (DSPE‐PEG) as excipients, were prepared and then characterized by dynamic light scattering (DLS) that revealed the formation of particles to be smaller than 200 nm in diameter. The resulting liposomal formulations showed moderate to excellent loading and entrapment efficiency, thus justifying the design of the compounds to fit in the lipid bilayer and ensuring ease of in vivo use for future application. The liposomal formulations based on cobalt and iron bis(dicarbollide)‐based lipids were found to be nontoxic against both human breast normal epithelial cells MCF‐10A and human breast cancer cells MCF‐7.
Polypyridyl‐Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition
Authors: Fantoni Nicoló Zuin , Molphy Zara , O'Carroll Sinéad , Menounou Georgia , Mitrikas George , Krokidis Marios G. , Chatgilialoglu Chryssostomos , Colleran John , Banasiak Anna , Clynes Martin , Roche Sandra , Kelly Suainibhe , McKee Vickie , Kellett Andrew 
Published: June 2020

AbstractWe report a series of copper(II) artificial metallo‐nucleases (AMNs) and demonstrate their DNA damaging properties andin‐vitrocytotoxicity against human‐derived pancreatic cancer cells. The compounds combine a tris‐chelating polypyridyl ligand, di‐(2‐pycolyl)amine (DPA), and a DNA intercalating phenanthrene unit. Their general formula is Cu‐DPA‐N,N' (whereN,N'=1,10‐phenanthroline (Phen), dipyridoquinoxaline (DPQ) or dipyridophenazine (DPPZ)). Characterisation was achieved by X‐ray crystallography and continuous‐wave EPR (cw‐EPR), hyperfine sublevel correlation (HYSCORE) and Davies electron‐nuclear double resonance (ENDOR) spectroscopies. The presence of the DPA ligand enhances solution stability and facilitates enhanced DNA recognition with apparent binding constants (Kapp) rising from 105to 107 m−1with increasing extent of planar phenanthrene. Cu‐DPA‐DPPZ, the complex with greatest DNA binding and intercalation effects, recognises the minor groove of guanine–cytosine (G‐C) rich sequences. Oxidative DNA damage also occurs in the minor groove and can be inhibited by superoxide and hydroxyl radical trapping agents. The complexes, particularly Cu‐DPA‐DPPZ, display promising anticancer activity against human pancreatic tumour cells within‐vitroresults surpassing the clinical platinum(II) drug oxaliplatin.
Model Discrimination for Multicomponent Distillation – A Geometrical Approach for Total Reflux
Authors: Waltermann Thomas , Schlueter Stefan , Benfer Regina , Knoesche Carsten , Górak Andrzej , Skiborowski Mirko 
Published: June 2020

AbstractWhile rate‐based models are available in commercial flowsheet simulation tools, packed distillation columns are still mostly designed based on the equilibrium stage model in combination with HETP values. In order to discriminate between both types of models in a simple way, this article proposes an algorithmic test, based on a geometric criterion for total reflux operation. Substantial differences are illustrated especially for wide‐boiling mixtures, while component‐specific mass transfer rates either increase or reduce the deviation. The derived results are validated by dedicated experiments.
Application of genetic algorithm to color recipe formulation using reactive and direct dyestuffs mixtures
Authors: Chaouch Sabrine , Moussa Ali , Ben Marzoug Imed , Ladhari Neji 
Published: June 2020

AbstractColor reproduction is a science in constant development. In this article, a new model to solve the color recipe prediction problem using a genetic algorithm is proposed. The objective is to optimize the color recipe prediction stage by determining the dyes to use in a mixture and their respective proportions to reproduce the target color. Two ranges of dyes were used for dyeing 100% cotton woven fabrics: three reactive dyes (CI Reactive Red 238, CI Reactive Yellow 145, and CI Reactive Blue 235) and four direct dyes (CI Direct Orange 34, CI Direct Red 227, CI Direct Blue 85, and CI Direct Black 22). The criterion of optimization, in reproducing the desired shades, is to minimize the CMC color difference between the desired reference color and the color resulting of the predicted recipe. The proposed algorithm revealed good results with small CMC color differences between target and reproduced colors. The effectiveness of the algorithm was also evaluated and proven by calculating errors between the predicted concentrations in the proposed recipes and the actual concentrations.
A many‐objective integrated evolutionary algorithm for feature selection in anomaly detection
Authors: Zhang Zhixia , Xie Liping 
Published: June 2020

SummaryAt present, irrelevant or redundant features in network traffic data occupy a lot of storage and computing resources, reducing the accuracy of network anomaly detection. Aiming at this problem, a many‐objective feature selection model is proposed in this article. The model takes the number of selected feature, false alarm rate, detection rate, precision and accuracy as the optimization objectives, and characterizes the performance of the feature selection method from different perspectives. At the same time, a many‐objective integration optimization algorithm (IN‐MaOEA) is designed to solve this model. First, the algorithm will build the evolution strategy pool and the dominance strategy pool, then a random probability strategy selection mechanism is designed to improve the algorithm's convergence and diversity. At the same time, an anomaly detection simulation was performed using the NSL‐KDD dataset. Experimental results show that the IN‐MaOEA algorithm can effectively improve the performance of detection.
Physical simulation of upper protective coal layer mining with different coal seam inclinations
Authors: Fang Feng , Shu Cai , Wang Hongtu 
Published: June 2020

AbstractProtective coal layer (PCL) mining is a preferred regional method for preventing coal and gas outbursts; stress‐relief of PCL mining is the prerequisite of pressure‐relief gas drainage. In order to study the stress‐relief effect of PCL mining on protected coal seams and determine the protection scope of PCL mining under different inclinations, this paper uses physical simulations to study the stress‐relief law and deformation characteristics of the strata during upper PCL mining with a gentle inclination (25°), an intermediate inclination (45°), and a steep inclination (65°). The results show that as the coal seam dip increases, the degree of deformation and failure of the overburden strata gradually decreases, the severe subsidence and expansion area of the overburden strata tends to gradually develop in the uphill direction of the working face, and the floor strata underlying the protective seam significantly expand toward the goaf. However, the absolute value of the upward movement of the floor strata is much smaller than that of the roof strata; and the greater the dip angle, the greater the ratio of floor displacement to roof subsidence. The stress‐relief curve of the protected layer is approximately U‐shaped. As the inclination of the coal seam increases, the stress‐relief range decreases gradually. The maximum relief‐stress and the stress release coefficient of the protected layer initially increase and then decrease. The stress concentration coefficient of the protected coal seam initially increases first and then decreases in both uphill and downhill of the working face in the PCL. As the inclination increases, the stress‐relief angle of the downhill boundary initially increases and then decreases, while the stress‐relief angle of the uphill boundary decreases gradually. Our research results provide guidance for the delimitation of the protected scope of PCLs with different dip angles.