bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of psychosocial factors in predicting the formalized human milk donation to nonprofit milk banks
Authors: Shepherd Lee , Lovell Brian 
Published: March 2020

AbstractHuman milk donation is important for improving the development of preterm infants. However, despite the importance of donating the human milk, relatively little research has tested which factors predict this form of donation. This study assessed the association between the psychosocial factors and formalized milk donation to a nonprofit milk bank. This study used a cross‐sectional design. Breastfeeding mothers (N = 556) completed measures assessing altruism, pride, instrumental and affective attitudes, subjective norm, perceived behavioral control, self‐efficacy, anxiety, and intention to donate human milk to a nonprofit milk bank. We also assessed whether participants requested additional information about donating the human milk. Instrumental and affective attitude, subjective norm, and self‐efficacy were positively associated with intention to donate milk. Self‐efficacy and intention were also uniquely associated with requesting the additional information. The intention to engage in the formalized milk donation to a nonprofit milk bank appears to be more likely if women view this action as beneficial, believe significant others support the action and think they have the ability to undertake this action. Women who think they have the ability to undertake this action and are willing to donate are more likely to request additional information. These findings might inform future experimental research and campaigns on the human milk donation.
Local environmental selection and lineage admixture act as significant mechanisms in the adaptation of the widespread East Asian pond skaterGerris latiabdoministo heterogeneous landscapes
Authors: Ye Zhen , Yuan Juanjuan , Zhen Yahui , Damgaard Jakob , Yamada Kazutaka , Zhu Xiuxiu , Jiang Kun , Yang Xin , Wang Wenwu , Wang Shujing , Liang Jingyu , Fu Siying , Chen Pingping , Bu Wenjun 
Published: March 2020

AbstractAimLocal environmental selection and lineage admixture have long been accepted as important adaptive mechanisms in adjusting widespread taxa to new environments. We studied a pond skater,Gerris latiabdominis, to explore the relative roles played by these two mechanisms in its process of adaptation to heterogeneous landscapes.LocationEast Asia.TaxonGerris latiabdominis Miyamoto, 1958.MethodsMitochondrial (COI, COII) and nuclear (ddRAD‐seq) markers were sequenced from 202 individuals. Phylogenetic and phylogeographical analyses were conducted to reveal the population genetic structure. The demographical history was simulated by approximate Bayesian computation (ABC). The single‐nucleotide polymorphisms (SNPs) that may have been subjected to natural divergent selection among the populations were assessed, and the recent migration rates were estimated. Finally, shifts in suitable habitat from the last interglacial (LIG) to the present were predicted through ecological niche modelling (ENM).ResultsWe found population structures inferred from both mitochondrial and nuclear genomes to be almost coincident and to correspond to temporal or spatial heterogeneity. The early Pliocene splitting event between the northern (NO) and southeastern (SE) groups is consistent with the ‘arid belt hypothesis’, followed by local environmental selection. Approximate Bayesian computation and gene flow estimation strongly suggested that the southwestern (SW) groups originated from a lineage admixture event between the SE and western (WE) groups and subsequently underwent ongoing gene flow from the SE group during the Pleistocene. The mito‐nuclear discordance pattern in the SW group was probably due to the ancient mitochondrial differentiation.Main conclusionOur results suggest that both local environmental selection and lineage admixture acted as significant mechanisms ofG. latiabdominisadaptation to heterogeneous landscapes in East Asia. Furthermore, this study showed that conclusions based exclusively on mitochondrial data might mislead taxonomic, phylogenetic and phylogeographical studies.
Associations between developmental trajectories of peer victimization, hair cortisol, and depressive symptoms: a longitudinal study
Authors: Ouellet‐Morin Isabelle , Cantave Christina , Paquin Stéphane , Geoffroy Marie‐Claude , Brendgen Mara , Vitaro Frank , Tremblay Richard , Boivin Michel , Lupien Sonia , Côté Sylvana 
Published: March 2020

BackgroundPeer victimization has been associated with long‐lasting risks for mental health. Prior research suggests that stress‐related systems underlying adaptation to changing environments may be at play. To date, inconsistent findings have been reported for the hypothalamic–pituitary–adrenal (HPA) axis, and its end product cortisol. This study tested whether peer victimization was associated with hair cortisol concentrations (HCC), and whether this association varied according to sex, timing, and changes in exposure. We also examined whether peer victimization differentially predicted depressive symptoms according to HCC.MethodsThe sample comprised 556 adolescents (42.0%; 231 males) who provided hair for cortisol measurement at 17 years of age. Peer victimization was reported at seven occasions between the ages of 6 and 15 years.ResultsPeer victimization was nonlinearly associated with HCC for boys only, whereas changes in peer victimization were related to HCC for boys and girls. Peer victimization predicted more depressive symptoms for all participants, except those with lower HCC.ConclusionsOur findings provide further support for persistent dysregulation of the HPA axis following exposure to chronic adversity, of which the expression may change according to sex and the severity of victimization.
Sodium–glucose cotransporters: Functional properties and pharmaceutical potential
Authors: Sano Ryuhei , Shinozaki Yuichi , Ohta Takeshi 
Published: March 2020

AbstractGlucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.
Hexyl aminolevulinate, 5‐aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non‐aggressive basal cell carcinomas: A non‐sponsored, randomized, prospective and double‐blinded trial
Authors: Salmivuori M. , Grönroos M. , Tani T. , Pölönen I. , Räsänen J. , Annala L. , Snellman E. , Neittaanmäki N. 
Published: March 2020

AbstractBackgroundIn the photodynamic therapy (PDT) of non‐aggressive basal cell carcinomas (BCCs), 5‐aminolevulinic acid nanoemulsion (BF‐200ALA) has shown non‐inferior efficacy when compared with methyl aminolevulinate (MAL), a widely used photosensitizer. Hexyl aminolevulinate (HAL) is an interesting alternative photosensitizer. To our knowledge, this is the first study using HAL‐PDT in the treatment of BCCs.ObjectivesTo compare the histological clearance, tolerability (pain and post‐treatment reaction) and cosmetic outcome of MAL, BF‐200 ALA and low‐concentration HAL in the PDT of non‐aggressive BCCs.MethodsNinety‐eight histologically verified non‐aggressive BCCs met the inclusion criteria, and 54 patients with 95 lesions completed the study. The lesions were randomized to receive LED‐PDT in two repeated treatments with MAL, BF‐200 ALA or HAL. Efficacy was assessed both clinically and confirmed histologically at three months by blinded observers. Furthermore, cosmetic outcome, pain, post‐treatment reactions fluorescence and photobleaching were evaluated.ResultsAccording to intention‐to‐treat analyses, the histologically confirmed lesion clearance was 93.8% (95% confidence interval [CI] = 79.9–98.3) for MAL, 90.9% (95% CI = 76.4–96.9) for BF‐200 ALA and 87.9% (95% CI = 72.7–95.2) for HAL, with no differences between the arms (P = 0.84). There were no differences between the arms as regards pain, post‐treatment reactions or cosmetic outcome.ConclusionsPhotodynamic therapy with low‐concentration HAL and BF‐200 ALA has a similar efficacy, tolerability and cosmetic outcome compared to MAL. HAL is an interesting new option in dermatological PDT, since good efficacy is achieved with a low concentration.
A novel research on isolation and characterization of Photobacterium damselae subsp. damselae from Pacific white shrimp, Penaeus vannamei, displaying black gill disease cultured in China
Authors: Wang Ziyan , Shi Chengyin , Wang Hailiang , Wan Xiaoyuan , Zhang Qingli , Song Xiaoling , Li Ge , Gong Miao , Ye Shigen , Xie Guosi , Huang Jie 
Published: March 2020

AbstractIn June 2019, massive mortalities of cultured Penaeus vannamei occurred in a local farm in Hainan Province, China. The diseased shrimp displayed evident black gills. Three bacterial strains 20190611001, 20190611007 and 20190611022 were isolated from hepatopancreas and gills of the diseased shrimp and identified as Photobacterium damselae subsp. damselae based on the sequence analysis of 16S rRNA and toxR genes. These three isolates showed haemolytic activities. Of them, strain 20190611022 isolated from hepatopancreas was selected and processed for pathogenic analysis. The calculated median lethal dose (LD50) was 9.75 ± 4.29 × 105CFU/g (body weight) by challenging P. vannameivia reverse gavage. The diseased shrimp displayed enlarged hepatopancreatic tubules and sloughing of epithelial cells in tubular lumens. The strain 20190611022 was also characterized by the testing of API 20NE systems and antibiotic susceptibility. The results of disc diffusion test showed that strain 20190611022 was sensitive to chloramphenicol, compound sulfamethoxazole, cefoperazone, ceftriaxone, ceftazidime and cefuroxime. To our knowledge, this is the first report of isolation and characterization of Photobacterium damselae subsp. damselae from natural diseased P. vannamei. Our findings can serve as a basis for further studies of its pathogenicity and provide technological support for disease controlling in shrimp aquaculture.
Associations Between Activities of Daily Living Independence and Mental Health Status Among Medicare Managed Care Patients
Authors: Albanese Anita M. , Bartz‐Overman Colin , Parikh, MD Toral , Thielke Stephen M. 
Published: March 2020

BACKGROUND/OBJECTIVESAlthough there is a strong cross‐sectional association between dependence in activities of daily living (ADLs) and decreased mental health, it is largely unknown how the loss of specific ADLs, or the combination of ADLs, influences mental health outcomes. We examined the effect of ADL independence on mental health among participants in a large survey of Medicare managed care recipients.DESIGN/SETTINGRetrospective cohort study.PARTICIPANTSA total of 104,716 participants in cohort 17 of the Medicare Health Outcomes Survey, who completed the baseline and follow‐up surveys in 2014 and 2016.MEASUREMENTSLinear regression models estimated the effects of loss of ADL independence on change in Mental Component Summary (MCS) score.RESULTSIn an adjusted model, loss of independence in eating, bathing, dressing, and toileting were associated with three‐ to four‐point declines in MCS, suggesting meaningful worsening. In a model that also included all six ADLs, loss of independence in each ADL was associated with declines in MCS, with the largest effects for eating and bathing. MCS decreased by 1.3 per each additional summative loss of ADL independence (P < .001).CONCLUSIONLoss of ADL independence was associated with large declines in mental health, with personal care activities showing the largest effects. Additional research can help to characterize the causes of ADL loss, to explore how older adults cope with it, and to identify ways of maximizing resilience. J Am Geriatr Soc 68:1301–1306, 2020.
DASH (Dietary Approaches to Stop Hypertension) dietary pattern and maternal blood pressure in pregnancy
Authors: Courtney A. U. , O’Brien E. C. , Crowley R. K. , Geraghty A. A. , Brady M. B. , Kilbane M. T. , Twomey P. J. , McKenna M. J. , McAuliffe F. M. 
Published: March 2020

AbstractBackgroundHigh blood pressure (BP) in pregnancy is associated with significant adverse outcomes. In nonpregnant populations, the DASH (Dietary Approaches to Stop Hypertension) diet is associated with reductions in blood pressure. The present study investigated the relationship between the DASH dietary pattern and maternal BP in pregnancy.MethodsThis is an observational study of 511 women who participated in the ROLO study (Randomized cOntrol trial of LOw glycaemic index diet for the prevention of recurrence of macrosomia), 2007–2011, Dublin, Ireland. Auscultatory blood pressure, systolic blood pressure (SBP) and diastolic blood pressure (DBP) measurements were taken. Mean arterial pressure (MAP) was calculated. Dietary intakes were recorded using 3‐day food diaries in each trimester. DASH scoring criteria were used to score and rank participants from low to high intakes of foods recommended in the DASH diet. Statistical analysis using analysis of variance and multiple linear regression were used to determine the relationship between maternal BP and DASH scores.ResultsDietary intake more closely resembling the DASH dietary recommendations throughout pregnancy was associated with a lower DBP (mmHg) in trimesters 1 [B: −0.70; 95% confidence interval (CI) = −1.21 to −0.18] and 3 (B: −0.68; 95% CI = −1.19 to −0.17), as well as lower MAP (mmHg) in trimesters 1 (B: −0.78; 95% CI = −1.33 to −0.25) and 3 (B: −0.54; 95% CI = −1.04 to −0.04), controlling for body mass index, age, education, energy intake and intervention grouping.ConclusionsThe DASH dietary pattern was associated with lower maternal BP in pregnancy among healthy women without hypertensive disorders of pregnancy. Despite the observational nature of these findings, the results demonstrate the potential for healthcare professionals to intervene to promote cardiovascular health in pregnancy.
Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial
Authors: Farshi Susan , Mansouri Parvin 
Published: March 2020

AbstractBackgroundMelasma is a difficult to treat pigmentation disorder. However, some successes have been attained by microneedling. The aim of the present study was to evaluate the efficacy of microneedling using meso‐depigmentation solution (mesoneedling) in comparison with standard microneedling, over a 4‐month treatment period.MethodsAs a part of this pilot study, 20 patients received microneedling on one side and mesoneedling on another side of their face. Treatment was repeated on a monthly basis for 4 months. Treatment efficacy was defined through Dermacatch® colorimetry, modified Melasma Area and Severity (mMASI) score determination, Investigator's Global Assessment (IGA), and patient questionnaires, whereby all assessments were conducted at the baseline, as well after 2 and 4 months of treatment.ResultsBefore treatments, mean difference between pigmented and normal skin calculated by Dermacatch® was 43.7 ± 20.12 and 44.6 ± 20.72 in microneedling sides and mesoneedling sides, respectively. After two and four sessions, these values declined to 34.5 ± 16.26 and 28.05 ± 13.79 on the side subjected to microneedling, while 29.75 ± 15.07 and 20.45 ± 10.58 were measured on the mesoneedling side. Statistically significant differences have been observed between microneedling and mesoneedling treatments at both time points (P = .0001, P = .0001). The mMASI scores obtained upon treatment completion were significantly lower on both the microneedling and the mesoneedling side. The IGA and patients' self‐assessment scores further confirmed that both treatments were effective in treating melasma, without producing any notable side‐effects or complications.ConclusionIn sum, both microneedling and mesoneedling are effective in decreasing melanin content in the epidermal melasma lesions.
Excessive screen time is associated with maternal rejection behaviours in pre‐school children
Authors: Erat Nergiz Meryem , Çaylan Nilgün , Yalçin Sıddika Songül , Oflu Ayşe , Tezol Özlem , Foto Özdemir Dilşad , Çiçek Şeyma , Yıldız Deniz 
Published: March 2020

AimEarly childhood screen exposure leads to multiple adverse health events and parents have a major influence on their children's screen time. Our aim was to determine the association between maternal acceptance–rejection/control behaviours and excessive screen exposure in pre‐school children.MethodsIn this cross‐sectional descriptive study, children aged 2–5 years who had daily screen time <1 h (n = 76) and >4 h (n = 62) were enrolled. A structured survey form and Parental Acceptance–Rejection/Control Questionnaire were completed by mothers.ResultsTotal rejection scores were found to be lower in those with screen time <1 h than cases with >4 h (82.7 ± 13.2, 89.3 ± 17.2; P = 0.015). In addition, higher hostility, neglect and reverse‐affection scores were detected in excessive screen‐exposed group (P = 0.033, P = 0.003, P = 0.047, respectively). Multivariate logistic regression analyses revealed that mothers' low acceptance of their children and high neglect score were associated with excessive screen exposure after adjusting possible confounding factors. The undifferentiated rejection and control behaviours of the mothers had no association with excessive screen exposure.ConclusionChildren with excessive screen time may have a problematic relationship with their mothers. The relationship between parent and child should be examined and corrective actions should be taken.
Renal protection of rhein against 5/6 nephrectomied-induced chronic kidney disease: role of SIRT3-FOXO3α signalling pathway
Authors: Wu Xiaoxiao , Liu Meiyou , Wei Guo , Guan Yue , Duan Jialin , Xi Miaomiao , Wang Jingwen 
Published: March 2020

Abstract

Objectives
The purpose of this study is to investigate the antifibrosis and anti-oxidation of rhein in vivo and in vitro, and to evaluate potential mechanisms involved in the treatment of chronic kidney disease (CKD).

Methods
In experimental animal studies, CKD was established by 5/6 nephrectomy (5/6Nx). Serum creatinine (Scr) and blood urea nitrogen (BUN) were determined. Histopathologic tests were performed by HE and Masson trichrome stained. The level of ROS was investigated by fluorescence microplate with the probe 2′, 7′-dichlorofluorescein diacetate (DCFH-DA). The protein expressions of p47phox and gp91phox were measured in 5/6Nx rats. In HK-2 cells, the expression of SIRT3 and Foxo3α was measured in SIRT3 knockdown conditions. The indicators of oxidation and fibrosisi were measured in SIRT3 knockdown conditions.

Key findings
The results showed that, in addition to reducing renal interstitial pathologic injury and collagen fibrils, rhein administration improved renal function. The protective mechanisms were attributed to active SIRT3/FOXO3α signalling pathway and then play the anti-oxidative capacity of rhein, as well as to subsequent antifibrotic effect.

Conclusion
Taken together, rhein protected kidney through SIRT3/FOXO3a involvement. The anti-oxidative capacity of rhein contributed to the protective effects including the subsequent antifibrotic responses.
Snack food consumption among Bangladeshi children, supplementary data from a large RCT
Authors: Jannat Kaniz , Luby Stephen P. , Unicomb Leanne , Rahman Mahbubur , Winch Peter J. , Hossain Md. Iqbal , Stewart Christine P. 
Published: March 2020

AbstractChildhood obesity has been associated with consumption of energy‐dense foods such as caloric beverages and fast foods. Many low‐ and middle‐income countries like Bangladesh are now experiencing a rising problem of noncommunicable diseases along with the long‐standing problem of stunting and undernutrition. WASH Benefits Bangladesh was a large community‐based cluster randomized controlled trial conducted in rural Bangladesh. Study clusters were randomized into seven arms: single nutrition (N); water (W); sanitation (S); hygiene (H); combined water, sanitation, and hygiene (WSH); WSH and nutrition (N + WSH); and a double sized control (C). Nutrition intervention messages included four promotional components: maternal nutrition, breastfeeding, complementary feeding, and lipid‐based nutrient supplements. The World Health Organization infant food frequency questionnaire (24‐hr recall and 7‐day recall) was administered at Year 1 and Year 2 of intervention. The likelihood of any snack food consumption was significantly lower (odds ratio 0.37: 95% confidence interval [0.28, 0.49]) in the nutrition intervention arms compared to the control arm in Year 2 follow‐up. In addition, in the water intervention arm, fewer children (about 50% less) consumed soft drinks, but not the other sugar‐sweetened beverages, compared with control in Year 2. There were no other differences between groups. Simple messages about balanced diet and feeding family foods were effective in lowering commercially produced snack food consumption of the young children in low‐income rural communities of Bangladesh. Provision of safe water apparently encouraged mothers to reduce offering unhealthy beverages to the young children.
Agricultural and empowerment pathways from land ownership to women's nutrition in India
Authors: Harris‐Fry Helen , Krishnan Sneha , Beaumont Emma , Prost Audrey , Gouda Sanghamitra , Mohanty Satyanarayan , Pradhan Ronali , Rath Suchitra , Rath Shibanand , Pradhan Shibnath , Mishra Naba Kishore , Allen Elizabeth , Kadiyala Suneetha 
Published: March 2020

AbstractLand size is an important equity concern for the design of ‘nutrition‐sensitive’ agricultural interventions. We unpack some of the pathways between land and nutrition using a cross‐sectional baseline survey data set of 4,480 women from 148 clusters from the ‘Upscaling Participatory Action and Videos for Agriculture and Nutrition’ trial in Keonjhar district in Odisha, India. Variables used are household ln‐land size owned (exposure) and maternal dietary diversity score out of 10 food groups and body mass index (BMI; kg/m2) (outcomes); and mediators investigated are production diversity score, value of agricultural production, and indicators for women's empowerment (decision‐making in agriculture, group participation, work‐free time and land ownership). We assessed mediation using a non‐parametric potential outcomes framework method. Land size positively affects maternal dietary diversity scores [β 0.047; 95% confidence interval (CI) (0.011, 0.082)] but not BMI. Production diversity, but not value of production, accounts for 17.6% of total effect mediated. We observe suppression of the effect of land size on BMI, with no evidence of a direct effect for either of the agricultural mediators but indirect effects of β −0.031 [95% CI (−0.048, −0.017)] through production diversity and β −0.047 [95% CI (−0.075, −0.021)] through value of production. An increase in land size positively affects women's decision‐making, which in turn negatively affects maternal BMI. The positive effect of work‐free time on maternal BMI is suppressed by the negative effect of household land size on work‐free time. Agriculture interventions must consider land quality, women's decision‐making and implications for women's workload in their design.