bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yishen Huazhuo Decoction Induces Autophagy to Promote the Clearance of Aβ1-42 in SAMP8 Mice: Mechanism Research of a Traditional Chinese Formula Against Alzheimer’s Disease
Authors: Wang Kai , Sun Weiming , Xu Jiachun , Qin Qijing , Yu Zhen , Cheng Ruzhen , Zhang Linlin , Liu Shuang , Zhou Zhen , Zhang Yulian , Cui Yuanwu 
Published: June 2020

Background:
Studies have found that autophagy could promote the clearance of Aβ. To promote and
maintain the occurrence of autophagy in Alzheimer's disease (AD) might be a potential way to reduce neuronal
loss and improve the learning and memory of AD.

Objective:
To investigate the possible mechanisms of Yishen Huazhuo Decoction (YHD) against AD model.

Methods:
Forty 7-month-old male SAMP8 mice were randomly divided into model (P8) group and YHD
group, 20 in each group, with 20 SAMR1 mice as control (R1) group. All mice were intragastrically
administered for 4 weeks, YHD at the dosage of 6.24g/kg for YHD group, and distilled water for P8 group and
R1 group. Morris water maze (MWM) test, Nissl’s staining, TEM, TUNEL staining, immunofluorescence
double staining, and western blot analysis were applied to learning and memory, structure and ultrastructure of
neurons, autophagosome, apoptosis index, Aβ, LAMP1, and autophagy related proteins.

Results:
The escape latency time of YHD group was significantly shorter on the 4th and 5th day during MWM
test than those in P8 group (P=0.011, 0.008<0.05), and the number of crossing platform in YHD group
increased significantly (P=0.02<0.05). Nissl’s staining showed that the number of neurons in YHD group
increased significantly (P<0.0001). TEM showed in YHD group, the nucleus of neurons was slightly irregular,
with slightly reduced organelles, partially fused and blurred cristae and membrane of mitochondria. The
apoptosis index of YHD group showed a decreasing trend, without statistically significant difference
(P=0.093>0.05), while Caspase3 expression in YHD group was significantly lower (P=0.044<0.05). YHD
could promote the clearance of Aβ1-42 protein, improve the expression of Beclin-1 and p-Bcl2 proteins, reduce
mTOR and p62 proteins.

Conclusions:
YHD could induce autophagy initiation, increase the formation of autophagosomes and
autolysosome, promote the degradation of autophagy substrates, thereby to regulate autophagy, thereby to
promote the clearance of Aβ1-42 to improve memory impairment in SAMP8 mice.
Evaluation of the Role of Silicone Intubation in Non-complicated External Dacryocystorhinostomy
Authors: Massoud Omar M. , Elbakary Molham A. , Shalaby Osama E. , Hashish Aiman A. 
Published: June 2020

Aim:
Evaluation of the role of silicone intubation in non-complicated External dacryocystorhinostomy (Ext-DCR).

Background:
Silicone intubation is described as a step of Ext-DCR. It was proposed that it may prevent obstruction involving the osteotomy or the common canaliculus. However, its necessity in non-complicated Ext-DCR is controversial.

Objective:
To study the effect of intubation and its duration on the results of non-complicated Ext-DCR.

Methods:
A prospective randomized interventional study that included 75 Ext-DCRs. Patients with a high risk of failure were not included. Patients were randomly distributed between 3 equal groups with either traditional 3 months intubation (group A), short-term intubation for 2-3 weeks (group B), or non-intubation (group C).

Results:
The success rate was 92%, 96%, and 92% in groups A, B, and C, respectively, with no significant differences (P = 0.853). Temporary foreign body sensation was reported in 16% in group A and 12% in group B. No significant complications were recorded in any of the 3 groups.

Conclusion:
Intubation (either short-term or 3 months) did not affect the results of Ext-DCR, which gives more evidence that it is not necessary in non-complicated cases.
Recent Patents on Control System of EDM Machine Tool
Authors: Xie Baocheng , Liu Jianguo , Chen Yongqiu 
Published: June 2020

Background:
Electrical Discharge Machining (EDM) has widely been used in manufacturing
high strength and high hardness of metal material due to the EDM process, which is free from mechanical
force. The control system, a core of the EDM machine tool, plays a major role in manufacturing
high strength and high hardness metal material in terms of machining efficiency and machining
quality of the process of EDM. Thus, more and more attention has been paid to the current trends of the
control system of the EDM machine tool.

Objective:
To meet the increasing requirements of machining quality and machining efficiency in the
EDM process, the control system of the EDM machine tool is being improved continuously.
Methods: This paper reviews current various representative patents related to the control system of the
EDM machine tool.

Methods:
This paper reviews current various representative patents related to the control system of the EDM machine
tool.

Results:
By summarizing a large number of patents about the control system of the EDM machine tool,
the parameter control system, the servo control system and the numerical control system of the EDM
machine tool are analyzed, and the development trend of the EDM machine tool control system has
been discussed.

Conclusion:
The optimization of the control system of the EDM machine tool is conducive to increasing
machining efficiency and machining quality in the EDM process. More relevant patents will be
invented in the future.
Upscaling Anodic Synthesis of TiO2 Nanotubes Film as Potential Material for Photoelectrocatalytic Applications: Influence of Electrolyte Overheating and Aging on Nanotube Morphology and Stability
Authors: Marien Cédric , Le Pivert Marie , Dirany Ahmad , Drogui Patrick , Cottineau Thomas , Robert Didier 
Published: June 2020

Background:
Among Advanced oxidation processes, heterogeneous photocatalysis have a
great interest, because it uses only light has a source of energy. One of the main limiting processes in
photocatalysis is the high probability of electron-hole pair’s recombination in the volume or at the surface
of the photocatalyst particles. TiO2 nanotubes grown by anodic synthesis are widely studied because
of the large number of potential practical applications especially in photocatalytic or photoelectrochemical
applications. However, the preparation of these electrodes at large scale is still challenging due to
some technological obstacles such as the electrochemical cell design or the precise control of nanotubes
morphology, especially regarding electrolyte ageing and overheating during the synthesis.

Objective:
This study examines the electrochemical synthesis of TiO2 nanotubes supported on large
titanium electrodes.

Methods and Results:
By understanding heat dissipation phenomenon during the synthesis, an optimized
electrochemical cell was designed to prepare 6x4 cm 2 anodes. Then we aimed to control precisely the
length of the nanotubes independently of electrolyte ageing. Indeed, It was previously observed that the
electrolyte composition evolves (ageing) during the nanotubes synthesis and hence leads to nonreproducible
nanotubes morphologies under time-controlled potentiostatic anodization conditions.

Conclusion and Perspectives:
To overcome this issue, we developed a Coulometric approach that allows
to synthesize, reusing the same electrolyte, several electrodes with a great precision and reproducibility
on the length of the nanotubes (2,7 μm ± 160 nm) despite electrolyte ageing. Subsequently,
these electrodes can be integrated in a photocatalytic or photoelectrocatalytic process in a real
wastewater treatment sector would be very relevant.
E-Tourism: Malaysian travellers intention in online accommodation booking
Authors: Abdul Rahim Fitriya , Lau Teck Chai , Ng David Ching Yat 
Published: June 2020

A great number of tourists has embraced online travel booking. This paper examines the influence of four factors, namely credibility, trustworthiness, perceived usefulness, and perceived ease of use on booking intention and explores whether the attitude mediates the relationship between trustworthiness and booking intention. A total of 191 completed and usable questionnaires from holidaymakers in Malaysia were collected. The results showed that perceived usefulness and perceived ease of use have a significant positive relationship with the booking intention. The result also highlighted that attitude partially mediates the relationship between trustworthiness and booking intention. The paper concludes with a discussion on managerial implications and suggestions to address this issue.
Keywords: holiday accommodations, holidaymakers, online booking, online information search.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI1.2320
Modalities to Address Legal Impediments to the Citizens’Right to Impart Public Sector Information
Authors: Mohamad Hashim Haswira Nor , Mahmood Anida , Mohamed Zain Fazlin , Suhaimi Nurul Shuhada 
Published: June 2020

This paper conducts a comparative analysis of various modalities currently being adopted in selected countries to address legal impediments to the citizens’ rights to impart public sector information (PSI). Previous studies have identified a myriad of laws currently in force in Malaysia which impede the citizens’ rights to impart PSI. In the absence of sui generis law on the right to information, disclosure, publication, communication and distribution of PSI is subject to these laws. This paper surveyed to identify the most appropriate modalities for adaptation in Malaysia and later suggested the appropriate modalities to address the legal impediments.
Keywords: Legal impediment; Right to information; Modalities; Citizens.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI1.2322
Sticking to the Old Ways in the Plea-Bargaining Process: Some evidence from Malaysia
Authors: Hamin Zaiton , Othman Mohd Bahrin , Abd Rani Ahmad Ridhwan 
Published: June 2020

In Malaysia, the plea-bargaining process was formalized in 2010 with the amendment to the Criminal Procedure Code 1976, which was intended to reduce the number of criminal cases that could be resolved at the pre-trial stage. However, the law in action does not appear to be in line with the law in the statute book. Hence, this paper aims at examining the reality of the plea-bargaining process and the extent of the applications in Malaysia. This paper adopts a qualitative methodology, of which the primary data is obtained from semi-structured while the secondary data obtained from library-based sources.
Keywords: Plea-Bargaining Process; Criminal Procedure; Prosecutor; Defence Counsel.
eISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI1.2324
THE EFFECTS OF TAWHIDIC PARADIGM ON PUBLIC POLICY MAKING IN MALAYSIA
Authors: Sarif Suhaimi Bin  Mhd , Ismail Yusof Bin 
Published: June 2020

This study examines the conceptualized effects of Tawhidic paradigm on economic policies to promote the growth of halal industry for sustainable wealth creation in Malaysia. Tawhidic paradigm provides guidance to economic policy thinking by relying upon the principles of Qurâ€™an and Sunnah in formulating and implementing policy blueprint and instruments. The current policy thoughts are guided by market forces and sentiments which contributed to unbridled uncertainties and speculation. A Tawhidic paradigm policy thinking and process is developed to help ascertain the level of Tawhidic based policy thinking and practices at policy making, implementation and evaluation. Using personal interview with economic policy makers as method of collecting input, this study reveals that the informants do consider some levels of Tawhidic paradigm but the thoughts appear to be inadequate to help sustain wealth creation.
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Efek Paradigma Tauhid dalam Pengambilan Kebijakan Publik di Malaysia________________________________________________
Studi ini ingin menguji dampak konsep paradigma Tauhid terhadap kebijakan ekonomi dalam mendorong pertumbuhan industri halal, demi terciptanya kekayaan berkelanjutan di Malaysia. Paradigma tauhid memberikan panduan pemikiran kebijakan ekonomi dengan mengandalkan prinsip-prinsip Alquran dan Sunnah dalam merumuskan dan menerapkan cetak biru instrumen kebijakan. Pemikiran kebijakan saat ini dipandu oleh kekuatan dan sentimen pasar yang berkontribusi terhadap ketidakpastian dan spekulasi yang tak terkendali. Pemikiran dan proses pemikiran tauhid dikembangkan untuk membantu memastikan tingkat pemikiran dan praktik kebijakan Tauhid berdasarkan pada pembuatan kebijakan, pelaksanaan dan evaluasi. Dengan menggunakan wawancara pribadi dengan pembuat kebijakan ekonomi sebagai metode untuk mengumpulkan masukan. Penelitian ini mengungkapkan bahwa informan mempertimbangkan beberapa tingkat paradigma Tauhid namun pemikiran tersebut tampaknya tidak memadai untuk membantu mempertahankan penciptaan kekayaan.
Indian Genocide – A Study Through The Works of Elizabeth Cook-Lynn
Authors: Chourey Poonam 
Published: June 2020

The research expounded the turmoil, uproar, anguish, pain, and agony faced by native Indians and Native Americans in the South Dakota region. To explain the grief, pain and lamentation, this research studies the works of Elizabeth Cook-Lyn. She laments for the people who died and also survived in the Wounded Knee Massacre. The people at that time went through huge exploitation and tolerated the cruelty of American Federal government. This research brings out the unchangeable scenario of the Native Americans and Native Indians. Mr. Padmanaban shed light on the works of Elizabeth Cook-Lynn who was activist. Mr. Padmanaban is very influenced with Elizabeth Cook-Lynn’s thoughts and works. She hails from Sioux Community, a Native American. She was an outstanding and exceptional scholar. She experienced the agony and pain faced by the native people. The researcher, Mr. Padmanaban is concerned the sufferings, agony, pain faced by the South Dakota people at that time. The researcher also is acknowledging the Indian freedom fighters who got India independence after over 200 years of sufferings. The foreign nationals entered our country with the sole purpose of business. Slowly and steadily the took over the reign of the country and ruled us for years, made all of us suffer a lot.
Impressions of The Agonised Women in Padma Sachdev’s “Caretaker”
Authors: Kapur Deepali 
Published: June 2020

Regional short stories in translation have always been a pasture of research in the field of English literature. It opens a vista of information, debate and discussion on the cultural and social crisis faced by the people lying hidden in the smaller pockets of our country. Jammu region is embedded with a rich heritage of Dogri language with an idiosyncratic regional flavour of its folk-tales and short-stories. Translation of Dogri works into other languages has helped the readers in the country and across borders, to peruse the social and cultural milieu of Jammu region. This paper critically examines the Dogri short story “Caretaker” by Padma Sachdev which reveals the agony, insecurities and position of Dogra women in the male-dominated society.
In the earlier Dogra society, women suffered at the hands of complex social‑cultural norms, rituals and patriarchal models of suppression. They were often forced into ill‑matched marriages and dohri (reciprocal marriages). Further, they were expected to become obedient wives to their husbands while their own identity got submerged under the burden of family responsibilities, catering to husband needs and rearing children. They often longed for a “home” of their own blessed with love and respect. However, the marital home failed to provide them this blessed home and the parental home became alien to them after marriage. The relationship between husband and wife seems like that of an orient and the occident as man becomes the agent of power, domination and male-centric prejudices against woman. On the other hand, woman acts as an orient who suffers from the societal prejudices for misinterpreted identity and enslavement for her social-cultural representation. As Simone de Beauvoir in her book, The Second Sex analyzes that man fundamentally tries to oppress women by characterizing them as the ‘Other’. Men impose his will on the other and women are cursed with the feelings of inwardness and suppressed voices. “[Man] attaches himself to woman –not to enjoy her, but to enjoy himself.” Hence, Padma Sachdev tries to echo a critical view of the patriarchal social institutions, which subjugate women’s identity for the gains of male supremacy. She also focuses on an unsaid bonding between women as they can sense the misery of each other. They may get corrupted by the feeling of insecurity at some point of time but soon they reconcile as they realise the pain of the other.
A Reading of Shakespeare’s Three Female Characters – Hermione, Portia and Calpurnia
Authors: Deenadhayalan Silvia P 
Published: June 2020

(A statement) is sexist if it contributes to, encourages or causes or results in the oppression of women. (Mills 83).
For many years, humanity has been ruled by a patriarchal society. In the male dominated society, women have been viewed as objects, marginals, subalterns or inferior human beings. Shakespeare’s tragedies are monolithic and the heroes occupy the centre and the women characters get a subordinated treatment. The heroes are given a free ‘voice’ but the women are simply their ‘echo’.
A Himalayan Love Story by Namita Gokhale as a Novel of Resistance by the Protagonist in Pursuit of Emancipation
Authors: Chhikara Harshita , Rana Randeep 
Published: June 2020

Love, especially unrequited love, has been the backdrop of numerous novels. A Himalayan Love Story by Namita Gokhale also has unrequited love as its central theme. This theme further helps to deconstruct the sexual confines of a woman, which helps her in her quest for identity. Namita Gokhale in the novel, A Himalayan Love Story, deals with the aforementioned theme presented in such a way that the familiar seems unfamiliar and we see it through a different lens, with a new perspective. She manoeuvers the classic theme of unrequited love into pursuit of emancipation for Parvati, the protagonist of the novel. Suppression of sexual desire often leads to mental illness. In this novel, not only Parvati suffers from mental but also a whole generation of females before her, for instance her mother died of mental illness. This mental illness is symbolic of subjection of women. Insanity in Parvati is suggestive of atrocities done to her by her homosexual husband and the society as well. The novel is an account of women’s tenacity, endurance and unwavering spirit against all odds. The beauty of the novel lies in the celebration of sexuality on one hand and rebellion against it on the other. The paper critically examines the subjugation of Parvati leading to her mental illness and her resistance against suppression in pursuit of emancipation and identity. The paper also tries to explore the psychological workings of the female psyche, which shapes their attitude and demeanor.
A Critical & Comparative Study of Freudian Concept with Bhagwad Geeta
Authors: Sharma Ankur , Tamta Mrs. Geetika 
Published: June 2020

“Shrimad Bhagwad Geeta” is a part of the great epic ‘Mahabharata” written thousands of years back by the sage Ved Vyaas. The book has eighteen chapters, which contain the quintessence of the entire philosophy and vast ocean of spiritual knowledge of Vedas, Upnishads, Shastras, combined with all the other scriptures and literatures of the ancient India and Sanatan Hindus. But Bhagwad Geeta is not for a particular person, or religion, race, caste, or country, rather it is that divine treasure of knowledge that has been given by the Lord Krishna Himself to the entire humanity. Each individual, who is alive and breathing on this earth, has an equal claim and right over the unparalleled and liberating knowledge of this wonderful song sung by Krishna. Saying anything about Bhagwad Geeta is like showing a lamp to the sun but at the same time it is absolutely pertinent and important to keep spreading the most invaluable gems and pearls of this divine source of knowledge with people in this era when everyone around seems to be stressed and depressed mentally, psychologically, emotionally, and spiritually because this great scripture has the immense potential within itself to answer all the questions and complications that are facing the modern civilizations and men today. It is the elixir that can bring the humanity to immortality and can free it of all the psychological bondages and make it healthy and blissful forever. This research paper attempts to draw the similarities between the theories of Freudian psychologically and the teachings from Geeta and at the same time it endeavours to highlight how this scripture marvelously resolves all the conflicts that remain unanswered by the modern scientific psychological thought.
The Blackness in The Bluest Eye
Authors: Xavier T. Roy , Manju Dr. A. J. 
Published: June 2020

Novels, of any time, carry certain stories related to reality. The earlier forms of the Novel, Allegory and Romance, contained religious, philosophical facts. These literary genres took the shape of Novels, which continue to carry moral, philosophical and historical truths. George Meredith, a Victorian novelist, defined Novel as the ‘summary of actual life’. According to William Henry Hudson, an English writer, Novel is an effective medium of the portrayal of human thoughts and actions.
The English word, Novel derived from the Italian term, Novelle, which means ‘a fresh story’. It was in 1350 that the Italian writer, Giovanny Boccassio, wrote his world famous collection of love stories in prose, named Decameron. Such stories in prose were called ‘novelle’ and a story in verse was known as ‘romance’. It meant a story of the legendary past. Malory’s Morte d’Arthur is an example. Some experts gave various definitions for a ‘Novel’. According to an American novelist, F. Marion Crawford, a Novel is a pocket theatre; a novel contained all accessories of a drama without requiring to be staged before an audience. George Meredith, an English novelist, called it a ‘summary of actual life’ including both ‘the within and the without’. According to W.H Hudson, Novel is an effective medium of the portrayal of human thought and action, ‘combining in itself the creations of poetry, the details of history and generalised experience of philosophy’.