bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaussian Process-Driven, Nested Experimental Co-Design: Theoretical Framework and Application to an Airborne Wind Energy System
Authors: Deese Joe , Tkacik Peter , Vermillion Chris 
Published: November 2020

Abstract
This paper presents and experimentally evaluates a nested combined plant and controller optimization (co-design) strategy that is applicable to complex systems that require extensive simulations or experiments to evaluate performance. The proposed implementation leverages principles from Gaussian process (GP) modeling to simultaneously characterize performance and uncertainty over the design space within each loop of the co-design framework. Specifically, the outer loop uses a GP model and batch Bayesian optimization to generate a batch of candidate plant designs. The inner loop utilizes recursive GP modeling and a statistically driven adaptation procedure to optimize control parameters for each candidate plant design in real-time, during each experiment. The characterizations of uncertainty made available through the GP models are used to reduce both the plant and control parameter design space as the process proceeds, and the optimization process is terminated once sufficient design space reduction has been achieved. The process is validated in this work on a lab-scale experimental platform for characterizing the flight dynamics and control of an airborne wind energy (AWE) system. The proposed co-design process converges to a design space that is less than 8% of the original design space and results in more than a 50% increase in performance.
An Experimental and Computational Investigation of a Pulsed Air-Jet Excitation System on a Rotating Bladed Disk
Authors: Kurstak Eric , D'Souza Kiran 
Published: November 2020

Abstract
Nonsynchronous vibrations are a difficult problem to address for turbomachines due to the complex nature of the forcing. Such vibrations can be caused by vortex shedding, flow instabilities, stall cells, or flutter. Testing a design with such excitations can be difficult in practice due to the required forcing. This work demonstrates an experimental excitation method using pulsed air jet excitation to create nonsynchronous vibrations in engine hardware rotating at nominal design speeds. Experimental runs were conducted to excite a number of engine orders (EOs). Blade tip timing was used to measure the blade response without interfering with the blade dynamics. The bladed disk was held at a constant rotational speed while the air jets were pulsed at a sweeping frequency to simulate rotating forcing. Computational models of the physical system were constructed using parametric reduced order models that incorporate the effects of rotational speed and small mistuning. The computational model was used in simulations that mimic the experiment; the forcing was swept across the blades while being pulsed. This results in a system response that cannot be captured using traditional harmonic analyses. The computational and experimental datasets were compared through mistuning values, amplitudes, and the nodal diameter (ND) content in the system response.
Computational Investigation of Protein Photoinactivation by Molecular Hyperthermia
Authors: Kang Peiyuan , Xie Chen , Fall Oumar , Randrianalisoa Jaona , Qin Zhenpeng 
Published: November 2020

Abstract
To precisely control protein activity in a living system is a challenging yet long-pursued objective in biomedical sciences. Recently, we have developed a new approach named molecular hyperthermia (MH) to photoinactivate protein activity of interest without genetic modification. MH utilizes nanosecond laser pulse to create nanoscale heating around plasmonic nanoparticles to inactivate adjacent protein in live cells. Here we use a numerical model to study important parameters and conditions for MH to efficiently inactivate proteins in nanoscale. To quantify the protein inactivation process, the impact zone is defined as the range where proteins are inactivated by the nanoparticle localized heating. Factors that reduce the MH impact zone include the laser pulse duration, temperature-dependent thermal conductivity (versus constant properties), and nonspherical nanoparticle geometry. In contrast, the impact zone is insensitive to temperature-dependent material density and specific heat, as well as thermal interface resistance based on reported data in the literature. The low thermal conductivity of cytoplasm increases the impact zone. Different proteins with various Arrhenius kinetic parameters have significantly different impact zones. This study provides guidelines to design the protein inactivation process by MH.
Finite Element Modeling of Tight Elastic Knots
Authors: Baek Changyeob , Johanns Paul , Sano Tomohiko G. , Grandgeorge Paul , Reis Pedro M. 
Published: November 2020

Abstract
We present a methodology to simulate the mechanics of knots in elastic rods using geometrically nonlinear, full three-dimensional (3D) finite element analysis. We focus on the mechanical behavior of knots in tight configurations, for which the full 3D deformation must be taken into account. To setup the topology of our knotted structures, we apply a sequence of prescribed displacement steps to the centerline of an initially straight rod that is meshed with 3D solid elements. Self-contact is enforced with a normal penalty force combined with Coulomb friction. As test cases, we investigate both overhand and figure-of-eight knots. Our simulations are validated with precision model experiments, combining rod fabrication and X-ray tomography. Even if the focus is given to the methods, our results reveal that 3D deformation of tight elastic knots is central to their mechanical response. These findings contrast to a previous analysis of loose knots, for which 1D centerline-based rod theories sufficed for a predictive understanding. Our method serves as a robust framework to access complex mechanical behavior of tightly knotted structures that are not readily available through experiments nor existing reduced-order theories.
Quantifying Throw Counts and Intensities Throughout a Season in Youth Baseball Players: A Pilot Study
Authors: Rose Michael J. , McCollum Katherine A. , Freehill Michael T. , Cain Stephen M. 
Published: November 2020

Abstract
Overuse injuries in youth baseball players due to throwing are at an all-time high. Traditional methods of tracking player throwing load only count in-game pitches and therefore leave many throws unaccounted for. Miniature wearable inertial sensors can be used to capture motion data outside of the lab in a field setting. The objective of this study was to develop a protocol and algorithms to detect throws and classify throw intensity in youth baseball athletes using a single, upper arm-mounted inertial sensor. Eleven participants from a youth baseball team were recruited to participate in the study. Each participant was given an inertial measurement unit (IMU) and was instructed to wear the sensor during any baseball activity for the duration of a summer season of baseball. A throw identification algorithm was developed using data from a controlled data collection trial. In this report, we present the throw identification algorithm used to identify over 17,000 throws during the 2-month duration of the study. Data from a second controlled experiment were used to build a support vector machine model to classify throw intensity. Using this classification algorithm, throws from all participants were classified as being “low,” “medium,” or “high” intensity. The results demonstrate that there is value in using sensors to count every throw an athlete makes when assessing throwing load, not just in-game pitches.
Numerical Study of Pool Boiling Heat Transfer From Surface With Protrusions Using Lattice Boltzmann Method
Authors: Mondal Kaushik , Bhattacharya Anandaroop 
Published: November 2020

Abstract
This paper reports our numerical studies on pool boiling heat transfer from a plane and with protruding surface using single component pseudo-potential phase change model of lattice Boltzmann method. The surface protrusions are assumed to be rectangular in shape with a given height and width. The surface protrusions are seen to promote nucleation of bubbles from the heated surface resulting in significantly higher heat transfer rates compared to the plane surface. Spatial and temporal averaged heat fluxes from all these protruding surfaces are found to be 3–4 times higher than that of a plane surface. The effects of the protrusion height, width, spacing, and associated geometrical parameters on surface heat flux have been investigated in order to arrive at an optimal design for maximum heat transfer.
Friction Evaluation for Combined Drawing and Ironing Process With Thick Sheet by Ball Ironing Test
Authors: Sae-eaw Nuttakorn , Aue-u-lan Yingyot 
Published: November 2020

Abstract
Ball ironing test (BIT) was proposed to evaluate the tribological conditions of the combined drawing and ironing process for thick sheets. This process was used to produce the products with controlled thickness at the sidewall, such as pulleys. Finite element modeling (FEM) was utilized to study the effects of the main geometrical parameters on friction from the BIT results and thereby design suitable tooling geometries. Clearance-to-thickness ratio (c/t), inner die radius (rd), and inner diameter of specimen (di) were adopted as process and specimen parameters. The results of the BIT comprised the maximum load and final height of the specimen. Slope sensitivity (λ) in the results was introduced to evaluate the friction sensitivity. According to the simulation, the maximum load was highly sensitive to the friction and was thus used as a friction indicator. Friction calibration curve (FCC) was established and fitted on the basis of a simplified mathematical model as a function of the maximum load and friction factor (m). The BIT with various types of lubricants was performed experimentally to evaluate the performances of the lubricants and approximate the friction factors. The solid lubricant, Zn-Ph coating, provided the least forming with m of 0.03. The liquid lubricant, oil with extreme pressure (EP) additives, performed similarly to the Zn-Ph coating with m of 0.07. In conclusion, the BIT test performed very well in ranking the lubricants and determining the friction value of the combined drawing and ironing process for thick sheets.
Construction of a Code Verification Matrix for Heat Conduction With Finite Element Code Applications
Authors: Toptan Aysenur , Porter Nathan W. , Hales Jason D. , Spencer Benjamin W. , Pilch Martin , Williamson Richard L. 
Published: November 2020

Abstract
When establishing the pedigree of a simulation tool, code verification is used to ensure that the implemented numerical algorithm is a faithful representation of its underlying mathematical model. During this process, numerical results on various meshes are systematically compared to a reference analytic solution. The selection of analytic solutions can be a laborious process, as it is difficult to establish adequate code confidence without performing redundant work. Here, we address this issue by applying a physics-based process that establishes a set of reference problems. In this process, code simulation options are categorized and systematically tested, which ensures that gaps in testing are easily identified and addressed. The resulting problems are primarily intended for code verification analysis but may also be useful for comparison to other simulation codes, troubleshooting activities, or training exercises. The process is used to select fifteen code verification problems relevant for the one-dimensional steady-state heat conduction equation. These problems are applicable to a wide variety of simulation tools, but, in this work, a demonstration is performed using the finite element-based nuclear fuel performance code BISON. Convergence to the analytic solution at the theoretical rate is quantified for a selection of the problems, which establishes a baseline pedigree for the code. Not only can this standard set of conduction solutions be used for verification of other codes, but also the physics-based process for selecting problems can be utilized to quantify and expand testing for any simulation tool.
Best Practices and Lessons Learned From Nuclear Materials Retrieval Programs of the United States Department of Energy
Authors: Abbott Kaatrin , Geroux Zachary 
Published: November 2020

Abstract
The Atomic Energy Act, as amended, authorizes the United States (U.S.) Department of Energy (DOE) and its predecessor agencies to distribute nuclear materials to public or private institutions for the purposes of education as well as research and development. Significant transformations throughout the nuclear industry have led to changes in programmatic responsibility for loaned nuclear materials. DOE has established several programs to catalog, transfer ownership, retrieve, and/or dispose of these loaned nuclear materials. The variety of loaned nuclear material types as well as operational and regulatory variations between facility licensees have created unique challenges for the retrieval and dispositioning processes. These include packaging and transportation, confirmation of regulatory jurisdiction, property transfer, and disposal of sources with no remaining economic value. This paper explores the methods and actions taken by DOE to address these challenges. Lessons learned and the best practices identified from these programs are also presented.
Computational Fluid Dynamics Simulations of the Cold Neutron Source at the OPAL Reactor
Authors: Spedding James , Ho Mark , Lu Weijian 
Published: November 2020

Abstract
The open pool Australian light-water (OPAL) reactor cold neutron source (CNS) is a 20 L liquid deuterium thermosiphon system which has performed consistently but will require replacement in the future. The CNS deuterium exploits neutronic heating to passively drive the thermosiphon loop and is cryogenically cooled by forced convective helium flow via a heat exchanger. In this study, a detailed computational fluid dynamics (CFD) model of the complete thermosiphon system was developed for simulation. Unlike previous studies, the simulation employed a novel polyhedral mesh technique. Results demonstrated that the polyhedral technique reduced simulation computational requirements and convergence time by an order of magnitude while predicting thermosiphon performance to within 1% accuracy when compared with prototype experiments. The simulation model was extrapolated to OPAL operating conditions and confirmed the versatility of the CFD model as an engineering design and preventative maintenance tool. Finally, simulations were performed on a proposed second-generation CNS design that increases the CNS moderator deuterium volume by 5 L, and results confirmed that the geometry maintains the thermosiphon deuterium in the liquid state and satisfies the CNS design criteria.
Data-Driven Identification of Nonlinear Flame Models
Authors: Ghani Abdulla , Boxx Isaac , Noren Carrie 
Published: November 2020

Abstract
This paper presents a data-driven identification framework with the objective to retrieve a flame model from the nonlinear limit cycle. The motivation is to identify a flame model for configurations, which do not allow the determination of the flame dynamics: that is commonly for industrial applications where (i) optical access for nonintrusive measurements of velocity and heat release fluctuations are not feasible and (ii) unstable combustion is monitored via multiple pressure recordings. To demonstrate the usefulness of the method, we chose three test cases: (i) a classical Rijke tube; (ii) an experiment of a laminar flame (EM2C case), (iii) and a high-pressure, turbulent premixed flame (German Aerospace Center (DLR) case). The procedure is as follows: First, acoustic network models for the three cases are generated for which the in-house software taX is employed. Next, the acoustic network models are embedded in an optimization framework with the objective to identify flame parameters that match the experimental limit cycle data: based on the instability frequency and pressure amplitudes, we formulate physical constraints and an objective function in order to identify the flame model parameters gain nopt and time delay τopt in the nonlinear regime. We demonstrate for the three cases that the identified flame parameters reproduce the unstable combustion processes and highlight the usefulness of the method for control purposes.
Large Deflection Model for Multiple, Inline, Interacting Cantilever Beams
Authors: Bebee Austin , Stubbs Christopher J. , Robertson Daniel J. 
Published: November 2020

Abstract
Numerous natural and synthetic systems can be modeled as clusters of interacting cantilever beams. However, a closed-form mathematical model capable of representing the mechanics of multiple interacting cantilever beams undergoing large deflections has yet to be presented. In this work, a pioneering mathematical model of the force–deflection response of multiple, inline, interacting (i.e., contacting) cantilever beams is presented. The math model enables the determination of the force–deflection response of a system of interacting cantilever beams and is predicated upon the “Pseudo Rigid Body Model” concept. The model was validated through data triangulation experiments which included both physical and computational studies. An analysis of the mathematical model indicates it is most accurate with deflections less than 50 deg. In the future, the model may be used in high throughput phenotyping applications for investigating stalk lodging and estimating the flexural rigidity of crop stems. The model can also be used to gain intuition and aid in the design of synthetic systems composed of multiple cantilever beams.
Protocol for a feasibility study of smoking cessation in the surgical pathway before major lung surgery: Project MURRAY
Authors: Lugg Sebastian T , Kerr Amy , Kadiri Salma , Budacan Alina-Maria , Farley Amanda , Perski Olga , West Robert , Brown Jamie , Thickett David R , Naidu Babu 
Published: November 2020

IntroductionSmoking prior to major thoracic surgery is the biggest risk factor for development of postoperative pulmonary complications, with one in five patients continuing to smoke before surgery. Current guidance is that all patients should stop smoking before elective surgery yet very few are offered specialist smoking cessation support. Patients would prefer support within the thoracic surgical pathway. No study has addressed the effectiveness of such an intervention in this setting on cessation. The overall aim is to determine in patients who undergo major elective thoracic surgery whether an intervention integrated (INT) into the surgical pathway improves smoking cessation rates compared with usual care (UC) of standard community/hospital based NHS smoking support. This pilot study will evaluate feasibility of a substantive trial.Methods and analysisProject MURRAY is a trial comparing the effectiveness of INT and UC on smoking cessation. INT is pharmacotherapy and a hybrid of behavioural support delivered by the trained healthcare practitioners (HCPs) in the thoracic surgical pathway and a complimentary web-based application. This pilot study will evaluate the feasibility of a substantive trial and study processes in five adult thoracic centres including the University Hospitals Birmingham NHS Foundation Trust. The primary objective is to establish the proportion of those eligible who agree to participate. Secondary objectives include evaluation of study processes. Analyses of feasibility and patient-reported outcomes will take the form of simple descriptive statistics and where appropriate, point estimates of effects sizes and associated 95% CIs.Ethics and disseminationThe study has obtained ethical approval from NHS Research Ethics Committee (REC number 19/WM/0097). Dissemination plan includes informing patients and HCPs; engaging multidisciplinary professionals to support a proposal of a definitive trial and submission for a full application dependent on the success of the study.Trial registration numberNCT04190966.
Association between platelet count and hepatocellular carcinoma overall survival: a large retrospective cohort study
Authors: Lu Linbin , Su Zhimin , Zheng Peichan , Wu Zhixian , Zhang Yan , He Huimin , Liu Jingnan , Lin Shan , Chen Xiong 
Published: November 2020

ObjectivesTo explore the non-linear relationship between platelet count (PLT) and hepatocellular carcinoma (HCC) overall survival (OS).SettingThe study was done in Sun Yat-sen University Cancer Center (SYSUCC) from January 2007 to May 2012, a total of 5005 consecutive participants at SYSUCC were retrospectively reviewed, and 979 patients with Barcelona clinic liver cancer (BCLC) stage B were selected for the final analysis.ParticipantsA total of 979 newly diagnosed patients with HCC with BCLC stage B were identified for the secondary analysis. Eight cases were excluded for missing data of PLT.Main outcome measuresCox proportional hazard regression models were used to calculate multivariable-adjusted HRs and 95% CIs for HCC. The non-linear relationship was estimated through a restricted cubic spline regression, and a two-piecewise Cox proportional hazards model was further performed to calculate the threshold effect. We used multiple imputation to deal with the missing data.ResultsIn the multivariate analysis, Log PLT was associated with a 91% risk increase in death (HR 1.91; 1.28 to 2.85) with adjustment for gender, Child-Pugh class, age × diameter of main tumour, both lobe with lesions × number of the intrahepatic lesions, alpha-fetoprotein (<25, ≥25) and lactic dehydrogenase (<245, ≥245). We also found a U-shape relationship between PLT and HCC OS at the inflexion point of 67.6×109/L. The HR was 0.12 (95% CI 0.03 to 0.52) for Log PLT≤10.83 and 3.07 (CI 1.91 to 4.92) for Log PLT>10.83 after adjusting for potential confounders. The core results were consistent with those from the sensitivity analysis. Besides, a significantly higher hazard risk was found in the patients with age <55, both lobes with lesions, tumour diameter >50, haemoglobin ≥120 and C reactive protein >10.ConclusionPLT was nonlinearly associated with HCC OS.