bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORPHOFUNCTIONAL DISORDERS OF THE MUSCULO OF THE ORAL CAVITY AND THEIR PREVENTION IN CHILDREN WITH DISEASES OF THE GASTROINTESTINAL TRACT IN ORTHODONTIC TREATMENT
Authors: Demchenko Dmitriy , Podoprigora Anna , Komarova Yuliya , Kalivradzhiyan Edvard , Stepanov Ilya , Shcherbinin Aleksandr 
Published: November 2020

Subject. At present, diseases of the gastrointestinal tract, with a high frequency in children aged 9―14 years, are accompanied by lesions of the oral mucosa. These conditions are aggravated with orthodontic treatment. Therefore, the development of a scheme for the prevention of complications in children with gastrointestinal diseases undergoing orthodontic treatment is an urgent task of modern dentistry.
Purpose ― to consider the problem of the state of the oral cavity and the cytological characteristics of the mucous membrane in children with gastrointestinal diseases, physiological occlusion and malocclusion undergoing orthodontic treatment, to investigate the dynamics of inflammatory processes of the jaw mucosa under the bases of removable orthodontic appliances.
Methodology. The study involved 60 children aged 7―15 years. The cytomorphometric method was used.
Results. The results of the study showed the possibility of using the cytomorphometric method for diagnosing and evaluating the effectiveness of the use of various prevention programs and medicines during orthodontic treatment. Cytomorphometry revealed significant differences in the effectiveness of the proposed prophylaxis scheme in children, contributed to the improvement of cytogram parameters and normalization of the inflammatory-destructive index, however, complete recovery of all cytomorphological parameters in patients undergoing orthodontic treatment did not occur.
Conclusions. To improve the level of oral hygiene for children undergoing orthodontic treatment, it is necessary to use not only therapeutic and prophylactic toothpastes, but also an additional amount of prophylaxis. Children with gastrointestinal tract diseases and malocclusion who are undergoing orthodontic treatment are recommended to include Lizobact drugs in the periodontal disease prevention regimen, however, the use of these drugs alone is not enough to completely eliminate the inflammatory process.
ARE SALIVARY CYTOKINES OF THE IL-1 FAMILY BIOMARKERS OF CHRONIC PERIODONTITIS?
Authors: Bazarnyy Vladimir , Polushina Larisa , Semencova Elena , Svetlakova Elena , Mandra Yuliya 
Published: November 2020

Subject. In recent systematic reviews, the question of the clinical value of cytokines of the interleukin-1 (IL-1) family in chronic periodontitis (CP) has been discussed. Some authors consider them to be reliable biomarkers, while others believe that although they allow differentiating gingivitis and severe CP, the quantity and quality of published works require further research in this area.
The aim of the study was to evaluate the clinical value of the level of cytokines of the IL-1 family in chronic mild periodontitis.
Methodology. All study participants were divided into two groups: main and control. The main group included 45 patients with mild chronic periodontitis, the control group consisted of 32 practically healthy volunteers without periodontal pathology. The concentration of IL-1α and IL-1β, IL-18, IL-1RA (receptor antagonist) in the oral fluid was determined by the method of multiparameter fluorescence analysis with magnetic microspheres (хMAP-technology, Luminex).
Results. In the group of patients with periodontitis, there was an increase in the oral fluid levels of IL-1RA by 3.14 times (p = 0.01), IL-1α - by 2.3 (p = 0.02) in comparison with the control group. The integral characteristic of the clinical value of the parameters (AUC) is quite high for both indicators: IL-1RA ― 0.91 and IL-1α ― 0.94. The content of IL-1β and IL-18 did not change significantly.
Conclusions. The study found an increase in the concentration of salivary cytokines of the IL-1 family in CP. Clinical and diagnostic characteristics of such tests as the content of IL-1α and IL-1RA in the oral fluid make it possible to consider them as biomarkers of mild chronic periodontitis.
Dostępność piesza, rowerowa i samochodowa do bibliotek w powiecie poddębickim
Authors: Sapińska Paulina 
Published: November 2020

W artykule zaprezentowano ocenę dostępności pieszej, rowerowej i samochodowej do bibliotek w powiecie poddębickim. Przedstawiono liczbę budynków mieszkalnych jednorodzinnych i wielorodzinnych na obszarach wyznaczonych przez izochrony: 0–5 minut, 5–10 minut oraz 10–15 minut od placówek bibliotecznych. Dostępność instytucji przeanalizowano, wykorzystując m.in. dane z zasobu OpenStreetMap oraz usługę sieciową WMS, prezentującą aktualną Bazę Danych Obiektów Topograficznych. Na podstawie przeprowadzonych badań stwierdzono, że najlepszą dostępnością pieszą i rowerową do badanych instytucji charakteryzuje się gmina Uniejów. Z kolei w przypadku dojazdu do bibliotek samochodem najlepszą dostępnością odznaczają się gminy Dalików, Poddębice i Zadzim, gdzie każdy z mieszkańców potencjalnie może dotrzeć tym środkiem lokomocji do placówki bibliotecznej.
Heterogeniczność przestrzenna postaw wyborczych mieszkańców gminy Uniejów w wyborach europejskich i parlamentarnych w 2019 roku
Authors: Kurzyk Paulina 
Published: November 2020

Niniejszy artykuł prezentuje zróżnicowanie postaw wyborczych mieszkańców gminy Uniejów podczas głosowań w 2019 r. Wybory, które odbyły się w zeszłym roku, miały charakter zarówno ponadnarodowy (wybory do Parlamentu Europejskiego), jak i krajowy (wybory parlamentarne). Zachowania wyborcze, które uwzględniono w pracy, obejmowały poparcie dla poszczególnych partii oraz frekwencję.
Tweets Responding to the Indonesian Government’s Handling of COVID-19: Sentiment Analysis Using SVM with Normalized Poly Kernel
Authors: Prastyo Pulung Hendro , Sumi Amin Siddiq , Dian Ade Widyatama , Permanasari Adhistya Erna 
Published: November 2020

Background: Handling COVID-19 (Corona Virus Disease-2019) in Indonesia was once trending on Twitter. The Indonesian government's handling evoked pros and cons in the community. Public opinions on Twitter can be used as a decision support system in making appropriate policies to evaluate government performance. A sentiment analysis method can be used to analyse public opinion on Twitter.Objective: This study aims to understand public opinion trends on COVID-19 in Indonesia both from a general perspective and an economic perspective.Methods: We used tweets from Twitterscraper library. Because they did not have a label, we provided labels using sentistrength_id and experts to be classified into positive, negative, and neutral sentiments. Then, we carried out a pre-processing to eliminate duplicate and irrelevant data. Next, we employed machine learning to predict the sentiments for new data. After that, the machine learning algorithms were evaluated using confusion matrix and K-fold cross-validation.Results: The SVM analysis on the sentiments on general aspects using two-classes dataset achieved the highest performance in average accuracy, precision, recall, and f-measure with the value of 82.00%, 82.24%, 82.01%, and 81.84%, respectively.Conclusion: From the economic perspective, people seemed to agree with the government’s policies in dealing with COVID-19; but people were not satisfied with the government performance in general. The SVM algorithm with the Normalized Poly Kernel can be used as an intelligent algorithm to predict sentiment on Twitter for new data quickly and accurately.
Booking Prediction Models for Peer-to-peer Accommodation Listings using Logistics Regression, Decision Tree, K-Nearest Neighbor, and Random Forest Classifiers
Authors: Afrianto Mochammad Agus , Wasesa Meditya 
Published: November 2020

Background: Literature in the peer-to-peer accommodation has put a substantial focus on accommodation listings' price determinants. Developing prediction models related to the demand for accommodation listings is vital in revenue management because accurate price and demand forecasts will help determine the best revenue management responses.Objective: This study aims to develop prediction models to determine the booking likelihood of accommodation listings.Methods: Using an Airbnb dataset, we developed four machine learning models, namely Logistics Regression, Decision Tree, K-Nearest Neighbor (KNN), and Random Forest Classifiers. We assessed the models using the AUC-ROC score and the model development time by using the ten-fold three-way split and the ten-fold cross-validation procedures.Results: In terms of average AUC-ROC score, the Random Forest Classifiers outperformed other evaluated models. In three-ways split procedure, it had a 15.03% higher AUC-ROC score than Decision Tree, 2.93 % higher than KNN, and 2.38% higher than Logistics Regression. In the cross-validation procedure, it has a 26,99% higher AUC-ROC score than Decision Tree, 4.41 % higher than KNN, and 3.31% higher than Logistics Regression. It should be noted that the Decision Tree model has the lowest AUC-ROC score, but it has the smallest model development time.Conclusion: The performance of random forest models in predicting booking likelihood of accommodation listings is the most superior. The model can be used by peer-to-peer accommodation owners to improve their revenue management responses.
The CES1 Gene rs2244613 Minor Allele Impact on the Safety Profile of Dabigatran Etexilate: Meta-Analysis
Authors: Abdullaev S. P. , Mirzaev K. B. , Bochkov P. O. , Sychev I. N. , Sychev D. A. 
Published: November 2020

Aim. A meta-analysis of studies on the CES1 gene c.1168-33A>C polymorphism (rs2244613) carriage influence on the equilibrium concentration and the risk of bleeding during dabigatran taking.Material and methods. The search was carried out in the Russian Science Citation Index, Google Academy, Medline PubMed, Embase databases. The meta-analysis included patients who according to the indications (atrial fibrillation, stroke, joint orthopedic surgery) were prescribed dabigatran in various doses. The association was identified in rs2244613 allele C carriers (genotypes AC and CC) and non-carriers (genotype AA). Quantitative synthesis was performed using OpenMetaAnalyst software. In statistical analysis the fixed effects model was used to estimate the influence of the allele C carriage on the any bleeding frequency and the random effects model was used to estimate the influence on the equilibrium plasma concentration level of dabigatran. The homogeneity of the analyzed studies was verified by Cochrane Q-test.Results. The analysis resulted in selection of 5 works matching all meta-analysis inclusion/exclusion criteria. All selected works included 2030 patients in total. The carriage of the rs2246613 allele C was associated with reduction of risk of any bleeding during dabigatran taking (risk ratio [RR] 0.732, 95% confidence interval [CI] 0.629-0.851; p<0.001). The heterogeneity test did not reveal any reliable differences between the study results (Q=2.183; p=0.535). The level of equilibrium residual concentration of dabigatran was not statistically significant lower for the carriers of C allele of the rs2244613 (mean difference -69.324, 95%CI -236.687-98.039; p=0.417). This might be related to the small sample size and the number of studies included in the meta-analysis. The heterogeneity test did not reveal statistically significant differences between studies (Q=0.388; I2=0%, p=0.534).Conclusion. The carriage of minor C allelic variant of rs2244613 reduces the risk of any bleeding during dabigatran taking, however, no significant association with decrease in dabigatran concentration was found.
Treatment of Patients with Acute Coronary Syndrome with ST Segment Elevation in Clinical Practice of the Republic of Karelia: the Results of 10-year Register
Authors: Skopets I. S. , Vezikova N. N. , Malafeev A. V. , Malygin A. N. , Litvinova V. A. 
Published: November 2020

Aim. To study the clinical course, treatment, and outcomes in the patients with ST segment elevation acute coronary syndrome (STeACS) in real clinical practiceMaterial and methods. Our study is based on data of 5694 patients who were sequentially hospitalized in the Regional Vascular Center from 01.01.2009 to 01.01.2019 due to STeACS and included in the Federal Hospital Register. Men prevailed (65.8%); the average age was 68 years old. 14.1% of the patients had the history of myocardial infarction (MI) before this hospitalization. The reperfusion strategy, drug therapy, as well as the risks of complications and outcomes in real clinical practice of the Republic of Karelia were analyzed. Descriptive statistics methods were used to evaluate the results.Results. In the study group a high frequency of reperfusion interventions (83.5%) with a predominance of percutaneous coronary intervention (PCI; 76.2%) was revealed, as well as optimal drug therapy in most patients. Thus, 99.4% of patients took aspirin, 82.8% – clopidogrel, 91.1% – anticoagulants, 91.6% – beta-blockers, 95.6% – statins, 94.2% – angiotensin-converting-enzyme inhibitors/angiotensin II receptors blockers. A risk assessment of hospital and 6-month mortality was performed using GRACE score. The distribution of the hospital risk mortality were the following: 25.7% of patients had a low (49-125 points), 33.7% an average (126-154 points), and 40.6% of patients had a high risk (more than 154 points). At the same time, the risk of 6-month mortality in a half of the patients (51.6%) was low (27-99 points), the average risk (100-127 points) was determined in 23.0% of patients and the high risk (more than 127 points) – in 25.5% of patients. Life threatening complications developed in 38.1% of patients and the most frequent ones were arrhythmias (31.5%). The outcomes at the discharge from the hospital were as follows: 1432 patients (63.5%) had Q MI, 390 (17.3%) – non Q MI, 76 (3.4%) – unstable angina, 21 (0.9%) – MI of unspecified localization and 317 patients (14.1%) – repeated myocardial infarction.Conclusion. According to the results of a 10-year hospital registry of patients with STeACS, a high frequency of reperfusion interventions and an optimal drug therapy in most patients was revealed. However, to increase the effectiveness of treatment, it is necessary to minimize temporary losses both at the prehospital treatment and during reperfusion.
Doctors’ Adherence to the Guidelines on the Oral Anticoagulants Usage
Authors: Perepech N. B. , Mikhailova I. E. , Tregubov A. V. 
Published: November 2020

Aim. To study doctors’ knowledge of the clinical guidelines on the use of oral anticoagulants and identify the reasons for poor adherence.Material and methods. The results of the 218 questionnaires completed by the doctors trained in the 2018-2019 were analyzed. The questionnaire included 12 items regarding the main aspects of oral anticoagulants use. 71.6% of respondents were cardiologists, 18.8% were therapists (including general practitioners) and 9.6% were representatives of other specialties.Results. The obtained data show that therapists are worse than cardiologists aware of indications for oral anticoagulants in atrial fibrillation, and do not always correctly assess the risk of thromboembolism. Only 24.4% of therapists consider prescribing rivaroxaban in a dose of 2.5 mg 2 times a day to a patient suffering from myocardial infarction with an ST segment elevation on the electrocardiogram. One third of therapists either do not know or do not support current recommendations regarding oral anticoagulants use in paroxysmal atrial fibrillation. 65.3% cardiologists are inclined to start anticoagulant therapy only in patients at high risk for thromboembolism, while 36.6% therapists are ready to start such treatment even at moderate risk. Respondents' answers to the questionnaire demonstrate their great alertness regarding possible bleeding. Overestimation of the bleeding risk is more often among therapists than cardiologists (44.9% and 17.1%, respectively). More than one third of therapists (36.6%) are ready to recommend a reduced dose of oral anticoagulant to patients without clear reasons. Fear of bleeding has a greater influence on the decision to prescribe an anticoagulant and the choice of treatment regimen for atrial fibrillation than the desire to effectively prevent thromboembolism.Conclusion. The results of the survey show that the doctors’ adherence to the clinical guidelines’ basic principles of the use of oral anticoagulants among cardiologists is higher than that of therapists. Wherein, even among cardiologists it cannot be considered sufficient. The lack of doctors’ awareness about the identification, assessment, and modification of risk factors for bleeding was revealed.
Postoperative Controls of ventilation tubes in children - by general practitioner or otolaryngologist? Study protocol for a multicenter randomized non-inferiority study (The ConVenTu study)
Authors: Austad Bjarne , Nilsen Ann Helen , Helvik Anne-Sofie , Albrektsen Grethe , Nordgård Ståle , Thorstensen Wenche Moe 
Published: November 2020

Abstract
Background: Otitis media with effusion is the major cause of acquired hearing problems in children. Some of the affected children need surgery with ventilation tubes in the tympanic membrane to reduce ear complaints and to improve hearing, middle ear function and health-related quality of life. This is one of the most common ambulatory surgeries performed on children. Postoperative controls are needed to assess that the tubes are functional, evaluate whether hearing loss has been improved, and to handle potential complications. The follow-up may continue for years and are usually done by otolaryngologists. Nevertheless: there exist no evidence-based guidelines concerning the level of expertise needed for postoperative controls of the ventilation tubes. The aim of this protocol is to describe the ConVenTu study that evaluates whether postoperative controls performed by general practitioners (GPs), represent a safe and sufficient alternative to controls performed by otolaryngologists. Methods/design: Multicenter randomized non-inferiority study conducted in clinical settings in seven hospitals located in Norway. Discharged children with ventilation tubes, aged 3-10 years are allocated randomly to receive postoperative controls by either an otolaryngologist at the hospital where they had ventilation tube surgery or their regular GP. Study participants are enrolled consecutively until 200 patients are included in each group. Two years after surgery we will compare pure tone average of hearing thresholds (primary endpoint) and middle ear function, complication rate, health-related quality of life and the parents’ evaluations of the postoperative care (secondary endpoints). Discussion: This protocol describes the first randomized non-inferiority study of GPs performing postoperative controls after surgery with ventilation tubes. Results from this study may be utilized for deriving evidence-based clinical practice guidelines of the level of postoperative controls after ventilation tube surgery which is safe and sufficient.
Pulling Metallic Glasses Ductile
Authors: Mota Rodrigo Ojeda , Lund Ethen , Sohn Sungwoo , Browne David , Schroers Jan 
Published: November 2020

Abstract
A major shortcoming of most known bulk metallic glasses (BMGs) is that they lack sufficient ductility, or toughness, when fabricated under conditions resulting in bulk glass formation. To address this, processing techniques to improve ductility that mechanically affect the glass have been developed, however it remains unclear for which BMG formers they work, and by how much. We show here that, instead of manipulating the glass state, an applied strain rate can excite the liquid, and simultaneous cooling results in freezing of the excited liquid into a glass with a higher fictive temperature. Microscopically, straining causes the structure to dilate, hence “pulling” the structure energetically up the potential energy landscape. Upon further cooling, the resulting excited liquid freezes into an excited glass that exhibits enhanced ductility. We use Zr44Ti11Cu10Ni10Be25 to demonstrate how pulling BMGs through this excited liquid cooling methods can lead to a tripling of the bending ductility.
Pre-Transplant Donor HBV DNA+ and Male Recipient are Independent Risk Factors for Treatment Failure in HBsAg+ Donors to HBsAg- Kidney Transplant Recipients
Authors: Wang Xianding , Feng Shijian , Liu Jinpeng , Song Turun , Huang Zhongli , Fan Yu , Shi Yunying , Chen Liyu , Xu Zilin , Li Xiaohong , Wang Li , Lin Tao 
Published: November 2020

Abstract
Background: In order to lighten the burden of organ shortage around the world, using potential infectious donor might be an option. However, scarce evidences have been published on Kidney transplantation (KTx) from hepatitis B surface antigen (HBsAg)+ donors to HBsAg- recipients [D(HBsAg+)/R(HBsAg-)] without hepatitis B virus (HBV) immunity. Here, we reported the results of D(HBsAg+/HBV DNA- or +)/R(HBsAg-) living KTx recipients with or without HBV immunity.Methods: We retrospectively identified 83 D(HBsAg+)/R(HBsAg-) living KTx recipients, and 83 hepatitis B core antibody (HBcAb)+ living donors to HBcAb- recipients [D(HBcAb+)/R(HBcAb-)] were used as control group by reviewing medical archives and propensity score matching. Treatment failure (defined as any HBV serology conversion, liver injury, graft loss, or recipient death) is the primary end-point.Results: 24 donors (28.9%) were HBV DNA+, and 20 recipients had no HBV immunity in the D(HBsAg+)/R(HBsAg-) group pre-transplantation. HBV prophylaxis was applied in all D(HBsAg+)/R(HBsAg-) recipients, however, we did not use any in D(HBcAb+)/R(HBcAb-) group. We observed a significant higher treatment failure in D(HBsAg+)/R(HBsAg-) than D(HBcAb+)/R(HBcAb-) group (21.7% vs. 10.8%, P<0.001). Interestingly, no significant difference was found between groups on HBV seroconversion, liver and graft function, rejection, infection, graft loss, or death. However, 2/20 recipients without HBV immunity in the D(HBsAg+)/R(HBsAg-) group became HBV DNA+ or HBsAg+, none observed in the D(HBcAb+)/R(HBcAb-) group. HBV DNA+ donor and male recipient were significant risk factors for treatment failure.Conclusion: D(HBsAg+)/R(HBsAg-) should be considered for living kidney transplantation, but with extra caution on donor with HBV DNA+ and male candidates.
Increased Expression of Fatty Acid and ABC Transporters Enhances Seed Oil Production in Camelina
Authors: Cai Guangqin , Wang Geliang , Kim Sang-Chul , Li Jianwu , Zhou Yongming , Wang Xuemin 
Published: November 2020

Abstract
Background: Lipid transporters play an essential role in lipid delivery and distribution, but their influence on seed oil production in oilseed crops is not well studied. Results: Here we examined the effect of two lipid transporters, FAX1 (fatty acid export1) and ABCA9 (ATP-binding cassette transporter subfamily A9) on oil production and lipid metabolism in the oilseed plant Camelina sativa. Overexpression (OE) of FAX1 and ABCA9 increased seed weight and size, with FAX1-OEs and ABCA9-OEs increasing seed length and width, respectively, whereas FAX1/ABCA9-OEs increasing both. FAX1-OE and ABCA9-OE displayed additive effects on seed oil content and seed yield. Also, OE of FAX1 and ABCA9 affected membrane lipid composition in developing siliques, especially on phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol. The expression of some genes involved in seed oil synthesis was increased in developing seeds of FAX1- and/or ABCA9-OEs. Conclusions: These results indicate that increased expression of FAX1 and ABCA9 can potentially be applied to improving camelina oil production.