bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards infield, live plant phenotyping using a reduced-parameter CNN
Authors: Atanbori John , French Andrew P. , Pridmore Tony P. 
Published: December 2019

AbstractThere is an increase in consumption of agricultural produce as a result of the rapidly growing human population, particularly in developing nations. This has triggered high-quality plant phenotyping research to help with the breeding of high-yielding plants that can adapt to our continuously changing climate. Novel, low-cost, fully automated plant phenotyping systems, capable of infield deployment, are required to help identify quantitative plant phenotypes. The identification of quantitative plant phenotypes is a key challenge which relies heavily on the precise segmentation of plant images. Recently, the plant phenotyping community has started to use very deep convolutional neural networks (CNNs) to help tackle this fundamental problem. However, these very deep CNNs rely on some millions of model parameters and generate very large weight matrices, thus making them difficult to deploy infield on low-cost, resource-limited devices. We explore how to compress existing very deep CNNs for plant image segmentation, thus making them easily deployable infield and on mobile devices. In particular, we focus on applying these models to the pixel-wise segmentation of plants into multiple classes including background, a challenging problem in the plant phenotyping community. We combined two approaches (separable convolutions and SVD) to reduce model parameter numbers and weight matrices of these very deep CNN-based models. Using our combined method (separable convolution and SVD) reduced the weight matrix by up to 95% without affecting pixel-wise accuracy. These methods have been evaluated on two public plant datasets and one non-plant dataset to illustrate generality. We have successfully tested our models on a mobile device.
Latarjet with cortical button fixation is associated with an increase of the risk of recurrent dislocation compared to screw fixation
Authors:   Study Investigators, Hardy Alexandre , Sabatier Vincent , Schoch Bradley , Vigan Marie , Werthel Jean David 
Published: December 2019

Abstract
Purpose
The purpose of this study was to compare the clinical results of the Latarjet procedure using two cortical buttons vs two screws. It was hypothesized that cortical button would result in similar rates of recurrent dislocations, but a lower rate of reoperation compared to screw fixation.

Methods
A retrospective comparative case-cohort analysis was performed for all patients undergoing a Latarjet procedure for recurrent anterior glenohumeral instability. Patient demographics, number of dislocations prior surgery, arm dominance, shoulder hyperlaxity, level of sport, type of sport and ISIS score were collected. Shoulders were separated into two groups based on surgical fixation (screws vs cortical button). Postoperatively, shoulders were evaluated for recurrent dislocation, revision surgery, post-operative Walch–Duplay score, and the Simple shoulder test (SST). Two hundred and thirty-six patients were included in the screw fixation group (group A) and 72 in button fixation group (group B) and were evaluated at a mean follow-up of 3.4 ± 0.8 years. Demographics of the two groups were similar with the exception of operative side hand dominance, which was more common in group B [50 (69.4%) vs 128 (54.2%), p = 0.02].

Results
Recurrent dislocation was significantly lower in Group A: 6 (2.5%) vs 6(8.3%) (p = 0.02). Reoperation was more common in group A [14 (5.9%) vs 0 (0%)]. At follow-up, Walch–Duplay scores and simple shoulder tests were similar in both groups.

Conclusion
Button fixation for Latarjet showed higher rates of recurrent dislocation compared to screw fixation. However, the increased stability afforded by screw fixation needs to be weighed against the increased risk of reoperation for hardware prominence.

Level of evidence
III.
Physical activity and sedentary behaviour and their associations with clinical measures in axial spondyloarthritis
Authors: Coulter Elaine H. , McDonald Marie Therese , Cameron Sara , Siebert Stefan , Paul Lorna 
Published: December 2019

AbstractEngaging in physical activity (PA) is a key aspect in the management of axial spondyloarthritis (axial SpA), however, its relationship with clinical measures is unknown. Previous research has mainly focused on subjective methods of measuring PA and sedentary behaviour (SB). The aim of this study was to explore the associations between objectively measured PA and SB with clinical measures in people with established axial SpA. Fifty participants were recruited from secondary-care rheumatology outpatient services in Glasgow, UK. Clinical measures collected included; Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Quality of Life (ASQOL) and the Six Minute Walk Test (6MWT). PA and SB were measured using the activPAL3 tri-axial accelerometer. Data from forty-five participants were included (23 males, average age 49 ± 12 years). Participants accumulated an average of 93.2 ± 41.5 min/day walking with an average of 7200 ± 3397 steps/day. The majority of the day (65%) was spent sitting, accumulated in prolonged bouts. Walking time and steps taken/day were associated with better BASFI (r = − 0.395, p = 0.007 and r = − 0.404, p = 0.006), ASQOL (r = − 0.375, p = 0.011 and r = − 0.361, p = 0.015) and 6MWT (r = 0.396, p = 0.007 and r = 0.421, p = 0.004); while longer walking events were associated with better BASMI (rho = − 0.352, p = 0.018), BASFI (rho = − 0.316, p = 0.034) and 6MWT (rho = 0.404, p = 0.006). SB was associated with worse ASQOL (r = 0.380, p = 0.010) and 6MWT (6MWT, r = − 0.357, p = 0.016). In people with axial SpA PA is associated with better function, exercise capacity and spinal mobility, while SB is associated with lower exercise capacity and poor quality of life. These findings support the promotion of PA and reduction of SB in people with axial SpA.
Effects of 1-year anti-TNF-α therapy on vascular function in rheumatoid arthritis and ankylosing spondylitis
Authors: Végh Edit , Kerekes György , Pusztai Anita , Hamar Attila , Szamosi Szilvia , Váncsa Andrea , Bodoki Levente , Pogácsás Lilla , Balázs Fruzsina , Hodosi Katalin , Domján Andrea , Szántó Sándor , Nagy Zoltán , Szekanecz Zoltán , Szűcs Gabriella 
Published: December 2019

AbstractAccelerated atherosclerosis, increased cardiovascular morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Vascular function, clinical and laboratory markers and the effects of anti-TNF therapy were assessed in arthritides. Fifty-three 53 patients including 36 RA patients treated with either etanercept (ETN) or certolizumab pegol and 17 AS patients treated with ETN were included in a 12-month follow-up study. Ultrasonography was performed to determine flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT) and arterial pulse-wave velocity (PWV) in all patients. All assessments were performed at baseline and 6 and 12 months after treatment initiation. A significant improvement of brachial artery FMD was observed after 6 months (p = 0.004). A tendency of FMD improvement was also observed after 12 months (p = 0.065). ccIMT did not change throughout the year. PWV significantly improved after 12 months (p = 0.034). Higher baseline ccIMT (p = 0.009) and PWV (p = 0.038) were associated with clinical non-response (cNR) versus response (cR) to biologics. Multiple analysis confirmed the association of baseline ccIMT with age (p = 0.003) and cNR (p = 0.009), as well as that of baseline PWV with age at diagnosis (p = 0.022) and current chest pain (p = 0.004). Treatment itself determined the 12-month changes in FMD (p = 0.020) and PWV (p = 0.007). In a mixed cohort of RA and AS patients, TNF inhibition improved or stabilized vascular pathophysiology. Inflammation may be associated with FMD, while, among others, cNR may influence vascular function.
Der Herzinsuffizienzchirurg – Hausarzt und Herzchirurg
Authors: Riebandt Julia , Hanke Jasmin S. 
Published: December 2019

ZusammenfassungBei der Therapie der terminalen Herzinsuffizienz handelt es sich um einen Wachstumsmarkt – sowohl für Kardiologen als auch für Herzchirurgen. Der besondere Reiz der Arbeit eines Herzinsuffizienzchirurgen besteht in der notwendigen Multidisziplinarität und der Tatsache, dass es nicht nur um den rein mechanistischen Zugang im Sinne der chirurgischen Therapie geht. Vielmehr macht ein Großteil der Arbeit die Vor- und Nachbehandlung aus, die meist durch den Chirurgen selbst ausgeführt wird. Umfassende herzchirurgische Kenntnisse sind ebenso unumgänglich wie das Verständnis kardiologischer und intensivmedizinischer Therapiekonzepte, um dem Patienten eine individuelle und sinnvolle Therapie anbieten zu können. Der vorliegende Beitrag bietet interessierten Kollegen einen Überblick über die Möglichkeiten und Anforderungen in diesem Teilgebiet der Herzchirurgie.
Bacterial colonization of Montgomery salivary bypass tubes after hypopharyngeal reconstruction in head and neck cancer patients
Authors: Grasl Stefan , Janik Stefan , Grasl Matthaeus Christoph , Parschalk Bernhard , Erovic Boban M. , Haymerle Georg 
Published: December 2019

Abstract
Background
Hypopharyngeal reconstruction after salvage pharyngolaryngectomy results in high postoperative morbidity. The use of salivary bypass tubes can reduce pharyngocutaneous fistula (PCF) formation. The influence of bacterial colonization has not been described in literature.

Methods
Bacterial swipes from 26 consecutive patients reconstructed after laryngopharyngectomy in combination with Montgomery salivary bypass tubes (MSBT) were analyzed in regards to PCF formation.

Results
PCF occurred in 2 untreated primary and in 9 salvage laryngopharyngectomies, respectively. Bacterial colonization showed high rates of gram-negative pathogens and drug resistance to standard Ampicillin treatment. Type of bacteria was not associated with fistula formation. Antibiotic resistance was found in 6 out 11 patients (54%) with PCF.

Conclusions
We identified high rates of antibiotic-resistant Gram-negative pathogens on MSBT. Although not statistically significant, PCF were found more frequently in drug-resistant patients. Bacterial colonization of hypopharyngeal reconstructions should therefore be taken into account for perioperative prophylaxis.
Low sun exposure increases multiple sclerosis risk both directly and indirectly
Authors: Hedström Anna Karin , Olsson Tomas , Kockum Ingrid , Hillert Jan , Alfredsson Lars 
Published: December 2019

Abstract
Objective
We aimed to study (1) to what extent the influence of low sun exposure on multiple sclerosis (MS) risk is mediated by low vitamin D levels; (2) whether low sun exposure or vitamin D deficiency act synergistically with HLA-DRB1*15:01 and absence of HLA-A*02:01.

Methods
We used two population-based case–control studies (7069 cases, 6632 matched controls). Subjects with different HLA alleles, sun exposure habits and vitamin D status were compared regarding MS risk, by calculating odds ratios (OR) with 95% confidence intervals (CI) employing logistic regression. Mediation analysis was used to identify the potential mediation effect of vitamin D on the relationship between low sun exposure and MS risk.

Results
Low sun exposure increased MS risk directly as well as indirectly, by affecting vitamin D status. The direct effect, expressed as OR, was 1.26 (95% CI 1.04–1.45) and the indirect effect, mediated by vitamin D deficiency, was 1.10 (95% CI 1.02–1.23). Of the total effect, nearly 30% was mediated by vitamin D deficiency. There was a significant interaction between low sun exposure and vitamin D deficiency (attributable proportion due to interaction 0.3, 95% CI 0.04–0.5) accounting for about 12% of the total effect. Further, both factors interacted with HLA-DRB1*15:01 to increase MS risk.

Interpretation
Our findings indicate that low sun exposure acts both directly on MS risk as well as indirectly, by leading to low vitamin D levels. The protective effect of sun exposure thus seems to involve both vitamin D and non-vitamin D pathways, which is of relevance for prevention, in particular for those with a genetic susceptibility to MS.
RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells
Authors: Ortner Nadine J. , Pinggera Alexandra , Hofer Nadja T. , Siller Anita , Brandt Niels , Raffeiner Andrea , Vilusic Kristina , Lang Isabelle , Blum Kerstin , Obermair Gerald J. , Stefan Eduard , Engel Jutta , Striessnig Jörg 
Published: December 2019

AbstractCav1.3 L-type Ca2+ channels (LTCCs) in cochlear inner hair cells (IHCs) are essential for hearing as they convert sound-induced graded receptor potentials into tonic postsynaptic glutamate release. To enable fast and indefatigable presynaptic Ca2+ signaling, IHC Cav1.3 channels exhibit a negative activation voltage range and uniquely slow inactivation kinetics. Interaction with CaM-like Ca2+-binding proteins inhibits Ca2+-dependent inactivation, while the mechanisms underlying slow voltage-dependent inactivation (VDI) are not completely understood. Here we studied if the complex formation of Cav1.3 LTCCs with the presynaptic active zone proteins RIM2α and RIM-binding protein 2 (RBP2) can stabilize slow VDI. We detected both RIM2α and RBP isoforms in adult mouse IHCs, where they co-localized with Cav1.3 and synaptic ribbons. Using whole-cell patch-clamp recordings (tsA-201 cells), we assessed their effect on the VDI of the C-terminal full-length Cav1.3 (Cav1.3L) and a short splice variant (Cav1.342A) that lacks the C-terminal RBP2 interaction site. When co-expressed with the auxiliary β3 subunit, RIM2α alone (Cav1.342A) or RIM2α/RBP2 (Cav1.3L) reduced Cav1.3 VDI to a similar extent as observed in IHCs. Membrane-anchored β2 variants (β2a, β2e) that inhibit inactivation on their own allowed no further modulation of inactivation kinetics by RIM2α/RBP2. Moreover, association with RIM2α and/or RBP2 consolidated the negative Cav1.3 voltage operating range by shifting the channel’s activation threshold toward more hyperpolarized potentials. Taken together, the association with “slow” β subunits (β2a, β2e) or presynaptic scaffolding proteins such as RIM2α and RBP2 stabilizes physiological gating properties of IHC Cav1.3 LTCCs in a splice variant-dependent manner ensuring proper IHC function.
The Impact of International Human Rights Law Ratification on Local Discourses on Rights: the Case of CEDAW in Al-Anba Reporting in Kuwait
Authors: George Rachel 
Published: December 2019

AbstractBy most measures, the impact of international human rights law ratification in the Arab Gulf region primarily in the 1990s and 2000s has been minimal. Scholars have found little evidence of correlation between ratification of the core human rights conventions with the minimal improvements in human rights practice in the region. Ratification of most human rights instruments Arab Gulf states in recent decades has, however, offered new cases from which to explore the impact of international human rights law in countries where human rights monitors find protections to be most limited. Using the case of Kuwait’s ratification of the Convention on the Elimination of all forms of Discrimination Against Women (CEDAW), this article examines the impact of ratification in 1994 on discourses on discrimination against women in national press on human rights in the country. Through analysis of reporting in national newspaperAl-Anba, the article identifies how ratification has shaped the language used in national press reporting on women’s rights to increasingly reference the convention and frame rights violations in the language of “discrimination.” In tracing these connections between the convention and related content in local press, the article identifies new avenue to explore the “impact” of human rights treaty ratification, even when formal changes in laws and policies so far have been limited.
A comprehensive phylogeographic study of Arion vulgaris Moquin-Tandon, 1855 (Gastropoda: Pulmonata: Arionidae) in Europe
Authors: Zając Kamila S. , Hatteland Bjørn A. , Feldmeyer Barbara , Pfenninger Markus , Filipiak Anna , Noble Leslie R. , Lachowska-Cierlik Dorota 
Published: December 2019

AbstractArion vulgarisMoquin-Tandon, 1855 is regarded as one of the 100 most invasive species in Europe. The native distribution range of this species is uncertain, but for many years, the Iberian Peninsula has been considered as the area of origin. However, recent studies indicate thatA. vulgarisprobably originated from France. We have investigated the genetic structure of 33 European populations (Poland, Norway, Germany, France, Denmark, Switzerland) of this slug, based on two molecular markers, mitochondrial cytochrome c oxidase subunit I (COI, mtDNA) and nuclear zinc finger (ZF, nDNA). Our investigation included published data from two previous studies, giving a total of 95 populations ofA. vulgarisfrom 26 countries. This comprehensive dataset shows comparable haplotype diversity in Central, North and Western Europe, and significantly lower haplotype diversity in the East. All haplotypes observed in the East can be found in the other regions, and haplotype diversity is highest in the Central and Western region. Moreover, there is strong isolation by distance in Central and Western Europe, and only very little in the East. Furthermore, the number of unique haplotypes was highest in France. This pattern strongly suggests thatA. vulgarishas originated from a region spanning from France to Western Germany; hence, the slug is probably alien/invasive in other parts of Europe, where it occurs. Our results indicate the necessity to cover as much of the distribution range of a species as possible before making conclusive assumptions about its origin and alien status.
Inactivation by helium cold atmospheric pressure plasma for Escherichia coli and Staphylococcus aureus
Authors: Lotfy Khaled , Khalil Sayed Mohammed , El-Raheem Hany Abd 
Published: December 2019

AbstractA helium cold atmospheric pressure plasma jet (HCAPPJ) driven by a commercial neon power supply was designed and utilized for inactivation bacteria. The generated reactive spices by HCAPPJ were investigated by optical emission spectroscopy. The reactive species of OH, OI, OI, N21+, N21+ and He were identified in the UV–Vis wavelength region. The reactive species was not detected between 200 nm and 300 nm, as the flow rate of helium gas increased that led to the plasma temperature reducing to a value near to the room temperature. In this work, we studied the impact of HCAPPJ on Gram-positive and Gram-negative bacteria. The survival amounts of the two types of bacteria were decreased vastly when the rate flow rate was equal to 10 L/min.
A robust optimization model for a biofuel supply chain under demand uncertainty
Authors: Delkhosh Fatemeh , Sadjadi Seyed Jafar 
Published: December 2019

AbstractThe growing demand for fuels combined with the fact that there are limited fossil fuel resources has led the world to seek renewable energy resources such as biofuels. Micro-algae can be an efficient source of biofuel energy, since it significantly reduces air pollution. In this paper, we develop a micro-algae biofuel supply chain through a two-stage approach. This study aims to commercialize micro-algae as a new source of energy. In the first stage, we utilize the Best-Worst Method (BWM) to determine the best cultivation system, and in the second stage, a bi-objective mathematical model is presented which simultaneously optimizes the economic and environmental objectives. We also propose a robust optimization model to deal with the uncertain nature of the biofuel supply chain. Our analysis on the trade-off between the supply chain’s total cost and unfulfillment demand arrives at interesting managerial insights. Furthermore, to show the effectiveness of the robust optimization model, we compare the performance of the robust and deterministic models, and the results show that the robust model dominates over the deterministic model in all scenarios. Finally, sensitivity analysis on critical parameters is conducted to help decision-makers find the optimal trade-off between investment and its benefits.
Synthesis and characterization of PbS nanowires doped with Tb3+ ions by using chemical bath deposition method
Authors: Koao L. F. , Hone Fekadu Gashaw , Dejene F. B. 
Published: December 2019

AbstractCrystalline lead sulfide (PbS) nanowires doped with terbium (Tb3+) ions were synthesized by the chemical bath deposition method at room temperature. The powder was obtained from an aqueous solutions using lead acetate dehydrate, terbium nitrate, thiourea, potassium hydroxide and ammonia. The terbium molar concentrations were varied in the deposition process to investigate the effect on the structural, optical, morphological and luminescent properties of PbS nanowires. The crystalline size was found to be dependent on the concentration of the Tb3+ ions used. The estimated average crystalline sizes were calculated from the X-ray diffraction and found to be 34, 33 and 37 nm for PbS: 0% Tb3+, PbS: 0.2% Tb3+ and PbS: 0.5% Tb3+, respectively. The scanning electron microscopy micrographs depict nanowire shape for the undoped as well as Tb-doped samples. The energy-dispersive X-ray and Auger electron spectroscopy analyses confirmed the presence of all the expected elements. The solid powder nanowires exhibited high absorptions in the UV–Vis regions. The band gap energies were estimated in the range of 1.99–2.46 eV. The absorption edge and the band gap energies of these PbS nanowires have shifted depending on the concentration of the dopant. The maximum luminescence intensity was obtained for PbS: 0.2% Tb3+ ions and luminescent quenching was observed for higher terbium concentrations.
Graphic abstract
Film Financing in the Digital Single Market: Challenges to Territoriality
Authors: Hugenholtz P. Bernt , Poort Joost 
Published: December 2019

AbstractThis article discusses the role of territorial licences for feature films against the background of judicial and market developments in the EU. Currently, territorial licences are deemed a cornerstone of the exploitation and financing of films in Europe. However, current models of film financing are under increasing pressure both from market developments such as the turbulent growth of global online video platforms, and from developments in EU law aimed at removing national territorial barriers to the Single Market. Examples are the rule of Union-wide exhaustion of the distribution right, the EU Portability Regulation and the country of origin rules for satellite broadcasting and online simulcasting. EU competition law sets additional limits to grants of territorial exclusivity, and prohibits clauses in broadcasting and pay television licences that prevent or restrict “passive” sales to consumers/viewers in non-licensed territories. The freedom of right holders to preserve territorial exclusivity by way of contract is likely to become increasingly vulnerable to EU competition law, as underlying territorial rights no longer support territorial grants. For the film sector where territorial exclusivity remains indispensable, the European Commission could create specific competition law rules in the form of “block exemptions”. Language exclusivity – i.e. exclusive grants of rights for distinct language versions of a film – could provide a practical and legally more robust alternative to territorial licensing.