bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation of an Unbiased Interactome for the Tetratricopeptide Repeat Domain of O-GlcNAc Transferase Indicates a Role for the Enzyme in Intellectual Disability
Authors: Stephen Hannah M. , Praissman Jeremy L. , Wells Lance 
Published: July 2020

AbstractThe O-GIcNAc transferase (OGT) is localized to the nucleus and cytoplasm where it regulates nucleocytoplasmic proteins by modifying serine and threonine residues with a non-extended monosaccharide, β-N-Acetyl-Glucosamine (O-GlcNAc). With thousands of known O-GlcNAc modified proteins but only one OGT encoded in the mammalian genome, a prevailing question is how OGT selects its substrates. Prior work has indicated that the N-terminal tetratricopeptide repeat (TPR) domain of OGT, rather than its C-terminal catalytic domain, is responsible for subcellular targeting and substrate selection. An additional impetus for exploring the OGT TPR domain interactome is the fact that missense mutations inOGTassociated with X-linked intellectual disability (XLID) are primarily localized to the TPR domain without substantial impact on activity or stability of the enzyme. Therefore, we adapted the BioID labeling method to identify interactors of a TPR-BirA* fusion protein in HeLa cells. We identified 115 high confidence interactors representing both known and novel O-GlcNAc modified proteins and OGT interactors. The TPR interactors are highly enriched in processes in which OGT has a known role (e.g. chromatin remodeling, cellular survival of heat stress, circadian rhythm), as well as processes i n which OGT has yet to be implicated (e.g. pre-mRNA processing). Importantly, the identified TPR interactors are involved in several disease states but most notably are highly enriched in pathologies featuring intellectual disability. These proteins represent candidate interactors that may underlie the mechanism by which mutations inOGTlead to XLID. Furthermore, the identified interactors provide additional evidence of the importance of the TPR domain for OGT targeting and/or substrate selection. Thus, this defined interactome for the TPR domain of OGT serves as a jumping off point for future research exploring the role of OGT, the TPR domain, and its protein interactors in multiple cellular processes and disease mechanisms, including intellectual disability.
The analysis of emission values from commercial flights at Dalaman international airport Turkey
Authors: Kafali Hasim , Altuntas Onder 
Published: July 2020

Purpose
This study aims to present atmospheric emissions (NOx, CO and HC) of commercial flights at Dalaman Airport for the years between 2016 and 2018.

Design/methodology/approach
Growing up, the potential for domestic and international airports will cause an increase in air transportation. Increasing demand for air transportation will cause adverse environmental impacts as well as positive economic contributions. Finding negative environmental effects and searching for solutions is an essential first step.

Findings
Emissions were calculated under three different groups (as daily, number of flights and per passenger). The maximum CO emission calculated was 1031.71 kg/day in August 2018, 41.55 g/pax. in October 2016 and 6909.27 g/flight in August 2018. The maximum HC emission calculated was 117.22 kg/day in August 2018, 4.78 g/pax. in May 2018 and 796.47 g/flight in May 2018. The maximum NOx emission calculated was 148.63 kg/day in August 2018, 6.04 g/pax. in October 2017 and 995.34 g/flight in August 2018.

Practical implications
The current study intends to show how can emission results differ under three different units.

Originality/value
The originality is the using of the real-time values for all calculations. The value of this study is to be key study for future applications of emission calculation methodologies.
The enhancement of the prescribed track for unmanned air vehicles
Authors: Usanmaz Oznur , Karaderili Murat , Sahin Ozlem , Savaş Tamer 
Published: July 2020

Purpose
Unmanned aerial vehicles (UAVs) are more affected by adverse wind conditions in especially landing. Therefore, they need to change the runway in use. In case of this change, to eliminate the uncertain maneuvers, there is a need for a special prescribed track. The purpose of this study is the construction of a prescribed track at a single runway to provide a facility to change the runway in use.

Design/methodology/approach
Two forms of prescribed tracks, as standard and alternate, were constructed for UAVs by taking into consideration the key parameters to design flight procedures. Both tracks were assessed in a real-time simulation method. Moreover, unmanned vehicle simulation was used for a validation process.

Findings
According to the real-time simulation results, 8.14 NM and 6.64 NM of flight distance and 5.43 min and 4.43 min of flight time for the standard and alternate prescribed tracks were found, respectively. The obtained results were in favor of the alternate prescribed track. Furthermore, the prescribed track was assessed and validated in both air traffic control and UAV simulations. The feedback of pilots and controllers was very positive for a prescribed track, as it provided them with foresight and time to take care in any situations.

Practical implications
The prescribed track in this paper may be applied by airspace designers and UAV users to perform safe and efficient landing in adverse wind conditions.

Originality/value
In this study, a prescribed track was constructed for UAVs. Quantitative results were achieved using a real-time simulation method in terms of flight distance and flight time. Additionally, validation of the prescribed track was achieved by unmanned air vehicle simulation.
Supply chain channel conflict coordination with consumer network acceptance
Authors: Liu Yong , Liu Zhi-yang , Li Jiao 
Published: July 2020

PurposeThe purpose of this paper is an attempt to design a proper incentive coordination mechanism to deal with the channel conflicts between the traditional sales and online direct sales.Design/methodology/approachWith respect to the problems of channel conflicts between the traditional sales and online direct sales, to optimize the sale system and get more profits, considering the influences of consumer network acceptance, the authors establish demand and profit function based on consumer's utility, respectively. What's more, we exploit the game theory to analyze the optional decisions of the supply chain under the incentive coordination condition and no incentive coordination condition, and then we discuss the supply chain's optimal pricing, demand, profit and compensation incentive levels with the different effect of consumer network acceptance.FindingsThe level of compensation incentive provided by the manufacturer is influenced by consumer network acceptance and product cost. The lower the consumer network acceptance, the better the compensation incentive coordination effect of manufacturers. Manufacturers, wholesalers, retailers and consumers are all important players in real supply chain relationships. When a manufacturer exists as a dominant role, it should pay full attention to the impact of consumer behavior on supply chain decisions.Practical implicationsThe research can clarify the influence and mechanism of consumer behavior on supply chain channel conflict coordination, and deal with channel conflicts.Originality/valueThe proposed incentive coordination can effectively realize supply chain channel conflict resolution, and provide decision-making ideas and methods for manufacturers to develop the supply chain management of online direct sales channels.
Review of construction journals on causes of project cost overruns
Authors: Durdyev Serdar 
Published: July 2020

PurposeThe study investigates the causes of project cost overruns (COs) that have been reported in the construction-management-related articles since 1985.Design/methodology/approachTo achieve the aim and provide recommendations to avoid project COs, 48 selected journal articles were reviewed and assessed with regard to the countries, institutions and researchers that have contributed to the subject.FindingsThe review of the articles shows that the subject has attracted a considerable attention from the researchers worldwide. However, the problem mainly occurred in developing countries and the researchers drew the attention on the resource-related, economic/financial as well as political problems. While 79 causes of COs were identified, the top ten causes of project COs, which have received the highest number of citations by the reviewed articles, were presented and discussed. These causes are: design problems and incomplete design, inaccurate estimation, poor planning, weather, poor communication, stakeholder's skill, experience and competence, financial problems/poor financial management, price fluctuations, contract management issues and ground/soil conditions.Research limitations/implicationsThe study findings have several implications, which are not only for the academic world, but also for the construction front line. For scholars, the study provides a list of project COs that the researchers in the area could benefit for their future studies. The industry practitioners could find ways to improve project cost performance by giving attention to the causative factors that are significantly affecting construction projects and investing their resources and efforts towards the most occurred ones.Originality/valueThus, this study provides insight into the research output on the subject and a checklist of COs, which is believed to provide a better understanding of significant areas requiring attention where steps should be taken to minimize or control factors causing COs in construction projects.
Evolutionary resilience in the housing sector: requirements proposal
Authors: Bigolin Morgane , Bussular Camilla Zanon , Silva Filho Luiz Carlos Pinto 
Published: July 2020

Purpose
This paper aims to discuss how to apply the evolutionary resilience theory in the housing sector, aiming to develop an alternative resilience framework for planning social housing programmes.

Design/methodology/approach
Based on the literature review, it was developed a theoretical framework for building evolutionary resilience. Based on this framework, the outline for the empirical research was specified through interviews with 21 multidisciplinary experts. The statements of these experts were examined through content analysis, as a means to assign a set of requirements for resilient buildings.

Findings
The analysis showed that the holistic framework based on evolutionary resilience could constitute a comprehensive and innovative resilience approach. The main contribution of the set of requirements was to adapt theoretical concepts by proposing operational surrogates, enabling such knowledge to be more applicable to devising resilience to the housing sector.

Originality/value
Resilience is establishing itself as one of the top agendas on the built environment. The construction sector, however, has yet to embrace the concept and little research has been conducted on a practical approach to assess the building’s resilience. This paper presents a list of practical requirements showing that the housing sector must to build differently to have a resilient future.
Oil-food price dynamics in an oil-dependent emerging economy
Authors: Adeosun Opeoluwa Adeniyi , Olayeni Olaolu Richard , Ayodele Olumide Steven 
Published: July 2020

Purpose
This paper aims to examine the transmission from oil price to local food price returns in Nigeria from January 1995 to May 2019.

Design/methodology/approach
To circumvent erratic behaviours and account for possibilities of noises at the edge of the wavelet signals, the paper combines wavelet and Markov-switching techniques to determine the significance and magnitude of oil–food price dynamics across different time scales.

Findings
It is shown that oil to food price pass-through changed across frequencies. Notably, results reveal a swift pass-through which signals the dominance of the direct effect of oil price shocks on food prices with evidence of weak spillover in the short term. The medium- and long-term horizons witness the dominance of the indirect effect of oil price shocks with much sluggish transmission to food prices; the highest significant pass-through of about 4% are also observed when the oil price is denominated in the naira–USD exchange rate.

Originality/value
The study improves understanding of the relationship between oil price shocks and domestic food price returns. It shapes policy prescription on appropriate inflation targeting strategies of monetary authorities.
Decision-making framework for using ambient assisted living
Authors: Alsulami Majid H. , Alsaqer Mohammed S. , Atkins Anthony S. 
Published: July 2020

Purpose
Technology plays an important role in assisting elderly people to live independently, longer and improve their quality of life and health, in supporting their daily activities, etc. The ageing population becomes a global phenomenon. The population of Saudi Arabia continues to age (>60 years of age) currently (5%) compared to other group ages. In 2050, it will increase rapidly to 20.9% of the Saudi population. The current research aims at examining the barriers that health-care providers in the Kingdom of Saudi Arabia are experiencing in the adoption of ambient assisted living (AAL) technologies among the elderly. The study aims to identify a challenging issue with the increasing the number of elderly among the population in the country, which has highlighted the need to use AAL technology to improve the quality of life among the elderly.

Design/methodology/approach
This study involved a community of practice (CoP) study as a method of data collection where data collected were presented and discussed in line with the existing literature review findings.

Findings
In total, 14 factors were identified in this study and discussed in the context of Saudi Arabia, which resulted in developing a decision-making framework for using AAL by health-care providers. Those factors are essential in boosting the usage of technology in improving elderly health in Saudi Arabia.

Research limitations/implications
This study includes implications for developing a decision-making framework for using AAL.

Social implications
This study clarifies that technology can connect elderly people with society.

Originality/value
In total, 14 factors were identified in this study and discussed in the context of Saudi Arabia.
Semantic assessment of smart healthcare ontology
Authors: Tiwari Sanju , Abraham Ajith 
Published: July 2020

PurposeHealth-care ontologies and their terminologies play a vital role in knowledge representation and data integration for health information. In health-care systems, Internet of Technology (IoT) technologies provide data exchange among various entities and ontologies offer a formal description to present the knowledge of health-care domains. These ontologies are advised to assure the quality of their adoption and applicability in the real world.Design/methodology/approachOntology assessment is an integral part of ontology construction and maintenance. It is always performed to identify inconsistencies and modeling errors by the experts during the ontology development. A smart health-care ontology (SHCO) has been designed to deal with health-care information and IoT devices. In this paper, an integrated approach has been proposed to assess the SHCO on different assessment tools such as Themis, Test-Driven Development (TDD)onto, Protégé and OOPs! Several test cases are framed to assess the ontology on these tools, in this research, Themis and TDDonto tools provide the verification for the test cases while Protégé and OOPs! provides validation of modeled knowledge in the ontology.FindingsAs of the best knowledge, no other study has been presented earlier to conduct the integrated assessment on different tools. All test cases are successfully analyzed on these tools and results are drawn and compared with other ontologies.Originality/valueThe developed ontology is analyzed on different verification and validation tools to assure the quality of ontologies.
Deformation mechanism and tribological behavior of hydrogen-free carburized layer on Ti-6Al-4V alloy
Authors: Tian Tian , Zhao Ruibo , Wei Dongbo , Yang Kai , Zhang Pingze 
Published: July 2020

Purpose
The purpose of this paper is to expound the relationship among microstructure, mechanical property, tribological behavior and deformation mechanism of carburized layer deposited on Ti-6Al-4V alloy by double-glow plasma hydrogen-free carburizing surface technology.

Design/methodology/approach
Morphologies and phase compositions of the carburized layer were observed by scanning electron microscope and X-ray diffraction. The micro-hardness tests were used to evaluate the surface and cross-sectional hardness of carburized layer. The reciprocating friction and wear experiments under various load conditions were implemented to investigate the tribological behavior of carburized layer. Moreover, scratch test with ramped loading pattern was carried out to illuminate the deformation mechanism of carburized layer.

Findings
Compared to substrate, the hardness of surface improved to ∼1,100 HV0.1, while the hardness profile of carburized layer presented gradual decrease from ∼1,100 to ∼300 HV0.1 within the distance of the total carburizing-affected region about 30 µm. The coefficient of friction, wear rate and wear morphology of carburized layer were analyzed. Scratch test indicated that the deformation process of carburized layer could be classified into three mechanisms (elastic, changing elastic–plastic and stable elastic–plastic mechanisms), and the deformation transition of the carburizing-affected region was from changing elastic–plastic to elastic mechanisms. Both the elastic and changing elastic–plastic mechanisms are conducive to the wearing course.

Originality/value
Using this technology, hydrogen embrittlement was avoided and wear resistance property of titanium alloy was greatly improved. Simultaneously, the constitutive relation during the whole loading process was deduced in terms of scratch approach, and the deformation mechanism of carburized layer was discussed from a novel viewpoint.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-11-2019-0489/
Systemic preconditions and ontological modeling for peri-urban communities
Authors: Nousala Susu , Galindo Kim Blanca , Romero David , Feng Xin , Aibeo Pedro 
Published: July 2020

PurposeThis research presents an ontological model, to communicate the impact of dynamic preconditions for peri-urban communities. As such, this paper approaches perturbation communities as social-complex-adaptive-systems.Design/methodology/approachPrevious assessment of dynamic preconditions have typically been based on top-down approaches. Through the lens of social-complex-adaptive and systemic design approaches (requiring a range of different disciplines), this work focuses on providing a broader view towards periurban research. The methodological approach involved academic literature, fieldwork observations, in-depth discussions with community, government, experts and research groups, focusing on a region called “Xochimilco” on the outskirts of Mexico City, a unique pre-Hispanic, Aztec ecosystem. This evolving man made agricultural/ecological structure of island plots, still provides environmental services to Mexico City. This region provides the basis of the research and subsequent ontological model. Ontology, in this instance, refers to the nature of being within a range of constraining dynamic forces relating to resilient behaviors of the current Xochimilco perturbation ecosystem.FindingsXochimilco can be considered as a longitudinal phenomenon that contributed to the understanding of observable resilient and precondition elements between the past and present of a living complex-adaptive-system.Practical implicationsThe research has provided a better understanding of community resilience through preconditions, contributing towards preparation of environmental change and future urbanization. To this end, the research focused on visualizing key dynamics elements for communities attempting to absorb new urban conditions (being continuously pushed into it).Originality/valueThe outcomes of this research have provided specific systemic, bottom up approaches with ontological modeling to assist with visualizing and understanding intangible dynamic conditions that impact high complex areas of perturbation regions.
Winter is coming: age and early psychological concomitants of the Covid-19 pandemic in England
Authors: Carson Jerome , Prescott Julie , Allen Rosie , McHugh Sandie 
Published: July 2020

PurposeThis paper aims to demonstrate early psychological concomitants of the Covid-19 pandemic in England on a sample of younger and older people.Design/methodology/approachA cross-sectional quantitative questionnaire (n = 1608) was conducted on the Prolific website. Participants completed the PERMA Scale (Flourishing), the four Office of National Statistics (ONS4) Well-being Questions, the Clinical Outcomes Measure in Routine Evaluation (CORE-10) and the short University of California Los Angeles Brief Loneliness Scale.FindingsData were gathered on March 18, 2020, near the start of the Covid-19 pandemic. This study looks at the effects of the developing pandemic on younger participants (18 to 25 years, n = 391) and older participants (60 to 80 years, n = 104). Flourishing levels for older participants were significantly higher (M = 107.96) than for younger participants (M = 97.80). Younger participants scored significantly higher on the ONS4 for anxiety and lower than the older participants for happiness, life satisfaction and having a worthwhile life. Levels of psychological distress (CORE-10) were also significantly lower for older participants (M = 9.06) than for younger participants (M = 14.61). Finally, younger participants scored significantly higher on the Brief UCLA Loneliness Scale (M = 6.05) than older participants (M = 4.64).Research limitations/implicationsFrom these findings, the Covid-19 pandemic was having a significantly greater effect on younger people in England, less than one week before the UK went into “lockdown”. Scores for both the Younger and Older groups on all the study measures were worse than normative comparisons. The study had no specific measure of Covid-19 anxiety, but nor was one available at the time of the survey.Practical implicationsThis study suggests that younger people (18 to 25) may be a more vulnerable group during the Covid-19 pandemic than many may have realized.Social implicationsAs a recent British Psychological Society report concluded, there is a lot of untapped wisdom amongst older groups in society.Originality/valueThis is one of the earliest studies to look at psychological distress before England went into “lockdown.”