bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hikikomori Risk Inventory (HRI-24): A new instrument for evaluating Hikikomori in both Eastern and Western countries
Authors: Loscalzo Yura , Nannicini Cristian , Huai-Ching Liu I-Ting , Giannini Marco 
Published: November 2020

Background: Hikikomori, a clinical condition widely studied in Japan, is receiving increasing attention in Western Countries. Aims: This study aimed to create a new instrument for evaluating the risk of Hikikomori in both Eastern and Western countries. Methods: Through two studies on Italian adolescents, youths, and adults ( n = 1,285) and a study on Japanese youths and adults ( n = 392), we analyzed the psychometric properties of the Hikikomori Risk Inventory (HRI-24). Results: We found support, in both the Italian and Japanese samples, for the good and stable factor structure of the scale (CFI = 0.94, RMSEA = 0.057 for both the adult samples), as well as for its convergent and divergent validity. Conclusions: The HRI-24 might be used in future studies in both Western and Eastern countries to shed light on the features of this clinical disorder in different cultures. This will allow the development of culture-sensitive preventive and clinical interventions.
Sternal wound infections during the COVID-19 pandemic: an unexpected benefit
Authors: Hussain Azhar , Ike David I , Durand-Hill Matthieu , Ibrahim Sammra , Roberts Neil 
Published: November 2020

Background The novel coronavirus, now termed SARS-CoV-2, has had a significant impact on cardiac surgical services globally. Although drastically reduced, our institution has maintained a significant level of cardiac surgical activity during the pandemic. Rigorous COVID-19 guidelines have been instituted to mitigate the risk of viral transmission. We observed a reduction in sternal wound infections since the institution of new perioperative surgical guidelines. Methods We performed a retrospective analysis of all patients who underwent cardiac surgery at our institution since a national lockdown was declared in March 2020. A retrospective analysis of all patients who underwent cardiac surgery in the 12 months preceding the national lockdown, as a baseline cohort group, was also performed. Results A total of 2600 patients (493 during the COVID-19 pandemic) were included in this study. Urgent/emergency procedures accounted for more than 60% of procedures performed during the lockdown compared to 39% previously. During the COVID-19 pandemic, there were 4 sternal wound infections with an overall incidence of 0.8%. In comparison, the incidence of sternal wound infections was significantly higher at 3.0% in the 12-month period prior to lockdown with 63 sternal wound infections ( p = 0.006). Conclusion This report suggests a significant role of iatrogenic causes in sternal wound infections prior to the pandemic. The strict implementation of guidelines in the perioperative period suggests that sternal wound infections can be prevented. We propose that the now widespread COVID-19 guidelines to reduce transmission risk be adapted to help reduce the incidence of sternal wound infections.
Socio-Cultural Factors Contributing to Being an Organ Donor in Iranian Employees
Authors: Khoshravesh Sahar , Karimi-Shahanjarini Akram , Poorolajal Jalal , Bashirian Saeed , Barati Majid , Hamidi Majid , Khalili Sanaz 
Published: November 2020

Aims The purpose of this study was to use a culturally modified Organ Donation Model (ODM) to explore the significant factors and ways in which these factors could influence signing the donor card. Methods This cross-sectional study was conducted among 600 employees from 57 offices in Hamadan, Iran, in 2018. Participants were selected randomly and surveyed on being a donor and their perceptions regarding signing the donor card. Structural equation modeling (SEM) was conducted to determine the inter-relationship between the studied variables. Results Participants’ mean age was 39.5 (SD = 7.0). 20% of participants had a signed donor card. Descriptive norms (β = 0.53, p < 0.001), non-cognitive beliefs (β=−0.33, p < 0.001), anticipated regret (β = 0.28, p < 0.001) and subjective norms (β=−0.17, p < 0.01) had significant direct effects on signing the donor card. Conclusion This study provides socio-culturally informed evidence on individuals' signing donor card. These factors could provide a guide to policymakers to develop the community-based interventions.
The mechanism of curcumin post-treatment relieving lung injuries by regulating miR-21/TLR4/NF-κB signalling pathway
Authors: Zou Hai-Bo , Sun Xiao-Feng 
Published: November 2020

Objective To investigate the mechanism by which curcumin prevents lung injury in a rat model of limb ischaemia-reperfusion injury. Methods Rats were randomized into four groups ( n = 20): control group (sham group); ischaemia-reperfusion group (I/R group); curcumin group (I/R+Cur group); and inhibitor of agomir-21 group (I/R+Cur+antagomir-21 group). At 3 h after reperfusion, lung tissues were collected for histopathology and immunohistochemistry to determine the apoptosis index (AI). Lung injury score (LIS) and lung wet/dry (W/D) ratio were determined. Lung microRNA-21 (miR-21) mRNA levels were measured using reverse transcription–polymerase chain reaction. Toll-like receptor 4 (TLR4) and nuclear factor kappa-B p65 (NF-κB p65) protein levels were measured by Western blot analysis. Tumour necrosis factor (TNF)-α and interleukin (IL)-1β levels were determined by enzyme-linked immunosorbent assays. Results In the I/R group, the W/D, LIS, AI, miR-21 mRNA, TLR4, NF-κB p65, TNF-α and IL-1β were significantly increased and the PaO2 was decreased compared with the sham group. Evidence of lung injury was observed in the I/R group and this was alleviated in the I/R+Cur group. An inhibitor of miR-21 (antagomir-21) reversed the protective effects of curcumin. Conclusion Curcumin post-treatment can alleviate the lung injuries induced by limb ischaemia-reperfusion via downregulating the levels of miR-21 mRNA.
Prognostic significance of autophagy-related genes Beclin1 and LC3 in ovarian cancer: a meta-analysis
Authors: Chen Xinbei , Sun Yang , Wang Bingrong , Wang Huihui 
Published: November 2020

Objective Beclin1 plays a central role in the activation of the autophagy signaling pathway. Beclin1 and LC3-related proteins are involved in the initial steps of autophagy, which are closely related to the occurrence and development of tumors. The current meta-analysis aimed to clarify the correlation between expression of Beclin1 and LC3 and prognosis of ovarian cancer. Methods We searched PubMed, Embase, The Cochrane Library, Web of Science, and CNKI using predefined selection criteria. Pooled hazard ratios and relative risks with 95% confidence intervals were used to evaluate the correlation between autophagy-related genes Beclin1 and LC3 and overall survival (OS), progression-free survival (PFS), and International Federation of Gynecology and Obstetrics (FIGO) stage. Results In total, 1497 patients from 10 articles were enrolled in this meta-analysis. Expression of Beclin1 was significantly correlated with improved OS and PFS, and increased expression of Beclin1 was correlated with early FIGO stage, but not with lymph node metastasis or histological grade. No association was found between LC3 expression and prognosis in patients with ovarian cancer. Conclusions Expression of Beclin1 is an independent risk factor for the progression of ovarian cancer. Thus, Beclin1 is a promising indicator in predicting prognosis in patients with ovarian cancer.
Irinotecan monotherapy as third- or further-line treatment for patients with small cell lung cancer
Authors: Seto Zenta , Takata Naoki , Murayama Nozomu , Tokui Kotaro , Okazawa Seisuke , Kambara Kenta , Imanishi Shingo , Miwa Toshiro , Hayashi Ryuji , Matsui Shoko , Inomata Minehiko 
Published: November 2020

Background: Small cell lung cancer (SCLC) is a very aggressive cancer and recurrence is inevitable. Treatment of recurrent disease is important for improving the prognosis of patients with SCLC. Methods: We conducted a retrospective observational study to investigate the efficacy and safety of irinotecan monotherapy as third- or further-line treatment in patients with SCLC. Results: Data of 15 patients who had received irinotecan monotherapy as third- or further-line treatment between 2004 and 2019 were analyzed. The median progression-free survival duration (95% confidence interval) from the initiation of treatment with irinotecan was 2.7 (1.4–3.8) months, and the median overall survival duration (95% confidence interval) from the initiation of irinotecan treatment was 10.0 (3.9–12.9) months. Partial response, stable disease or non–complete response/non–progressive disease, and progressive disease were observed in 1, 6, and 8 patients, respectively. Adverse events ⩾ grade 3 in severity were observed in 2/2 (100%) patients who were homozygous for UGT1A1 mutation, 2/3 (66.7%) patients who were heterozygous for UGT1A1 mutation, 4/6 (66.7%) patients who had wild-type UGT1A1, and 2/4 (50.0%) patients in whom the UGT1A1 mutation status was unknown. Conclusion: Our results suggest that irinotecan monotherapy can be a useful alternative treatment option in the third-line setting for patients with SCLC.
Recurrent retroperitoneal solitary fibrous tumor: a case report
Authors: Manica Michele , Roscigno Marco , Naspro Richard , Sodano Mario , Milesi Laura , Gianatti Andrea , Da Pozzo Luigi F. 
Published: November 2020

Background: Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm described initially in visceral pleura but can occasionally involve other sites such as the urinary tract. Extrapleural localizations are often indolent but some malignant SFTs have been described. The treatment and the most important prognostic factor for SFT seem to be complete resection of the neoplasm. Case report: We report the 10-year history of a retroperitoneal SFT, which recurred twice after conservative management, and was eventually treated with en bloc resection of the mass, the bladder, and the prostate, and urinary diversion by ileal conduit. To our knowledge, this case has the longest follow-up in the literature. Conclusion: Extrapleural SFTs often have indolent but unpredictable behavior as they can recur even after many years. Some histologic features are associated with the malignancy of these tumors. Complete resection of the neoplasm is the most important prognostic factor. Patients with SFT should be considered for a very long follow-up after the surgery due to the risk of possible late recurrences.
Who Publishes in Economic Education? A Bibliographic Analysis of the First 50 Years of the Journal of Economic Education
Authors: Grimes Paul W. , Mixon Franklin G. 
Published: November 2020

We examined the characteristics of the authors who published academic articles in the Journal of Economic Education ( JEE) during its first 50 years and identify those economists who were most productive in developing economic education as a specialized field. Employing bibliometric data, we review trends in the salient characteristics of authorship with special attention paid to gender, geography, institutional affiliation, and other factors. We also explore the JEE’s impact on the development of teaching-related research through citation analysis over the course of the journal’s various editorial regimes. The results reveal the relative impacts of authors and their economic education scholarship over the past half century and provide some insight into the possible future of the field. JEL Classifications: A20, A14
How Do Migrant Nursing Home Staff Relate to Religion in Their Work With Patients Who Are Approaching Death?
Authors: Lavik Marta Høyland , Gripsrud Birgitta Haga , Ramvi Ellen 
Published: November 2020

Aim To investigate how migrant nursing home staff relate to religion in their care for patients who are approaching death. Method and Theory Individual in-depth interviews were conducted with 16 migrant health care workers from five nursing homes in Norway. The overall analytic approach was hermeneutical. The parts and the whole were interpreted in light of each other to gain a “thick description” of the data material in order to show the ways in which experiential meaning-making draws on cultural webs of sign ificance. Findings Religion held various meanings for the migrant health care workers interviewed. Religious and cultural competence and knowledge of migrant nursing home staff was neither asked for by the management nor discussed in the staff group. The way our participants related to religion at work was therefore based on individual preferences and internalized practices. Conclusion and Implication for Practice Organized reflection groups among staff are needed in order to integrate and develop religious literacy in the multicultural nursing home setting. Such reflection groups can help the individual staff member to perform holistic nursing, that is, to be attentive of the interconnectedness of biological, social, psychosocial, and spiritual aspects in a human being.
On the wind resource in Algeria: Probability distributions evaluation
Authors: Ounis Houdayfa , Aries Nawel 
Published: November 2020

The present study aims to present a contribution to the wind resource assessment in Algeria using ERA-Interim reanalysis. Firstly, the ERA-Interim reanalysis 10 m wind speed data are considered for the elaboration of the mean annual 10 m wind speed map for a period starting from 01-01-2000 to 31-12-2017. Moreover, the present study intends to highlight the importance of the descriptive statistics other than the mean in wind resource assessment. On the other hand, this study aims also to select the proper probability distribution for the wind resource assessment in Algeria. Therefore, nine probability distributions were considered, namely: Weibull, Gamma, Inverse Gaussian, Log Normal, Gumbel, Generalized Extreme Value (GEV), Nakagami, Generalized Logistic and Pearson III. Furthermore, in combination with the distribution, three parameter estimation methods were considered, namely, Method of Moment, Maximum Likelihood Method and L-Moment Method. The study showed that Algeria has several wind behaviours due to the diversified topographic, geographic and climatic properties. Moreover, the annual mean 10 m wind speed map showed that the wind speed varies from 2.3 to 5.3 m/s, where 73% of the wind speeds are above 3 m/s. The map also showed that the Algerian Sahara is windiest region, while, the northern fringe envelopes the lowest wind speeds. In addition, it has been shown that the study of the mean wind speeds for the evaluation of the wind potential alone is not enough, and other descriptive statistics must be considered. On the other hand, among the nine considered distribution, it appears that the GEV is the most appropriate probability distribution. Whereas, the Weibull distribution showed its performance only in regions with high wind speeds, which, implies that this probability distribution should not be generalized in the study of the wind speed in Algeria.
Visualization of the posterior surface of the lens nucleus with triamcinolone acetonide in phacoemulsification
Authors: Mizuguchi Tadashi , Horiguchi Masayuki , Tanikawa Atsuhiro 
Published: November 2020

Purpose: We report a novel technique for visualizing the posterior surface of the lens nucleus during phacoemulsification. Surgical Technique: Hydro-dissection was performed using a solution of 20 mg triamcinolone acetonide powder without preservatives mixed with 3 ml BSS-plus, and triamcinolone acetonide was clearly identifiable underneath the posterior surface of the lens nucleus. Using a phaco-tip, the nucleus was shaved to the level of the triamcinolone acetonide and could be easily divided. The remnant triamcinolone acetonide was aspirated as much as possible from the lens cortex with an infusion/aspiration tip. Subjects and Evaluation Technique: Twenty-eight eyes in 28 patients with cataracts were enrolled in this study. Triamcinolone acetonide-assisted phacoemulsification was performed in 13 eyes in 13 patients (triamcinolone acetonide-phacoemulsification group), and normal phacoemulsification was performed in 15 eyes in 15 patients (phacoemulsification group). Intraocular pressure was measured in all patients pre-operatively, 1 day after, and 1 week after surgery. Corneal endothelial cell density was measured pre-operatively and 1 month after surgery. The time of surgical phacoemulsification (surgical phaco time) was measured from the video of the surgery. Results: Surgery was successively performed in all eyes. Pre-operative and post-operative intraocular pressures and cell densities did not significantly differ between the two groups. Surgical phaco time was shorter in the triamcinolone acetonide-phacoemulsification group than in the phacoemulsification group (157.1 ± 51.7 s vs 225.3 ± 45.1 s; p = 0.006). Conclusion: The triamcinolone acetonide-assisted phacoemulsification procedure is safe and useful for visualizing the posterior surface of the lens nucleus and facilitates removal of the lens nucleus by phacoemulsification.
Development and utility of the Family-Centered Autism Navigation interview
Authors: Pizur-Barnekow Kris , Lang Amy C , Barger Brian 
Published: November 2020

Navigating various systems, resources, and supports available for families of children with autism spectrum disorder is challenging. Family navigation is a potentially important support system for families of children with autism spectrum disorder. Family navigators are professionals who engage with families to enhance access to early identification and intervention services via shared navigation plans that help meet the family’s priorities and goals when navigating systems of support. Systematic processes and tools facilitating the development of a shared navigation plan with families following diagnosis are currently limited. This short report describes product development of the Family-Centered Autism Navigation using quality improvement methods including Lean Launch and qualitative methodology. Lay abstract When a parent learns of their child’s autism diagnosis, they may be overwhelmed, confused, and frustrated. Family navigation services are designed to improve access to care. While these services are a promising intervention to enhance well-being and developmental outcomes, there are limited tools that can systematically facilitate the development of a shared navigation plan that prioritizes the concerns of the family. The Family-Centered Autism Navigation semi-structured interview guide is designed for family navigators to triage and prioritize caregiver’s needs to coordinate and navigate systems of care after learning of their child’s autism spectrum disorder diagnosis. The goals of the Family-Centered Autism Navigation interview are to (1) identify family and child strengths; (2) identify family/caregiver concerns regarding navigation of services and systems following their child’s diagnosis of autism; (3) measure change in caregiver knowledge, ability and skill as it relates to understanding, remembering, and evaluating information they receive; and (4) assist with the development of a shared navigation plan. When using the Family-Centered Autism Navigation guide, family navigators and caregivers co-create a family-centered, prioritized action plan that supports and prepares caregivers as they navigate systems of care. This short report describes the development process of the Family-Centered Autism Navigation semi-structured interview guide. We utilized brief interviews ( n = 42), expert feedback ( n = 13), and quality improvement strategies ( n = 2 family navigators) to develop the questions and determine the usability of the Family-Centered Autism Navigation interview in practice.
Dementia families: Relinquishing home care to aged care services: Guilt, traumatic loss and growth
Authors: Walmsley Bruce D , McCormack Lynne 
Published: November 2020

Background and Objectives Few studies explore both negative and positive perspectives of family members who relinquish home care of a family member with dementia for systemic aged care. Research Design and Methods This phenomenological study sought the ‘lived’ experience of relinquishing the role of home carer for a family member with mild to severe dementia to others within care home settings, by seeking to understand the impact of aged care on family members’ psychological well-being. Using semi-structured interviews, positive and negative subjective interpretations from 17 families (27 individuals) provided data for analysis, following the protocols of interpretative phenomenological analysis. Results One superordinate theme, mistrust/integrity, overarched oscillation between mistrust of the aged care system and a struggle for personal integrity in caring for these participants. Two sub-themes emerged: intrinsic trauma and extrinsic trauma. Intrinsic trauma explained feelings of helplessness and guilt, and internally directed responses that triggered a retreat into submission ultimately reducing the participant’s role in advocacy. Extrinsic trauma represented externally directed responses such as anger and frustration, where family members became more engaged and watchful and recognised a need for vigilance and advocacy. Paradoxically oscillating between these personal struggles, participants exhibited growth, a third theme that defined assertive/advocacy utilised to nurture hope, gratitude, courage and change. Discussion and Implications Family members experienced complex distress as they relinquished home care to others within systemic aged care for a member with dementia. By developing adaptive responses as appropriate, for example, advocating for their family member or accepting compliance with treatment, collaborative care between family and staff created better outcomes for the family member with dementia.
Synovial sarcoma of the elbow presenting with painful stiffness: a case report
Authors: Nevin Jennifer L , King Graham JW 
Published: November 2020

Elbow stiffness is a challenging problem for the upper extremity surgeon to treat. It can significantly impact the patient’s function in activities of daily living. While the most common etiologies are post-traumatic or secondary to arthritis, a large variety of etiologies should be considered with atypical presentations. It is important that the upper-extremity surgeon have a systematic approach to the diagnosis and management of elbow contracture in order to ensure malignant processes are considered. We present an unusual case of a young patient with atraumatic, non-arthritic elbow stiffness whose underlying diagnosis was a synovial sarcoma, as well as a review of the literature and differential for elbow stiffness. Level of evidence: IV.