bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROLE OF HYPERCORTISOLEMIA IN PROGRESSION OF THE COMORBID COURSE OF CORONARY ARTERY DISEASE, DIABETES MELLITUS TYPE 2 AND ANEMIA
Authors: Pavliukovych Nataliia , Pavliukovych Oleksandr , Buriak Oleksandr , Kopchuk Tamara , Vivsyannuk Volodymyr 
Published: October 2019

INTRODUCTION: Hyperactivation of stress-limiting mechanisms of the organism is a unique physiological response of the human being to chronic hypoxia of different origins.
OBJECTIVES: Investigation of dynamics of cortisol synthesis changes in patients with coronary artery disease with comorbid diabetes mellitus type 2 and anemic syndrome in patients of older age groups.
METHODS: Blood cortisol level was measured in 40 old and senile coronary artery disease patients with comorbid diabetes mellitus type 2 and anemic syndrome of different degrees of severity. The control group consisted of 12 patients with coronary artery disease without comorbidities that were not significantly different through gender and age from the patients of the research groups. Possible effects of telmisartan on the degree of chronic hypoxia were also investigated.
RESULTS: In patients of old and senile age with coronary artery disease and comorbid anemic syndrome, same as in case of coronary artery disease and anemic syndrome on the background of diabetes mellitus type 2, activation of the cortisol synthesis is observed, likely in response to hypoxia as a stress factor in anemia. The degree of severity of the detected changes was different depending on the degree of anemia severity. There was no normalization of cortisol content in blood in any of the major experimental groups regardless the prescribed treatment with ACE inhibitors or telmisartan.
CONCLUSIONS: In patients with coronary artery disease, same as in the case of a comorbid course of coronary artery disease and diabetes mellitus type 2, an increase of cortisol secretion in response to anemic hypoxia was observed. As the degree of severity of the anemic syndrome progressed, gradual decreasing of cortisol blood level was detected. Reduction of the intensity of stress-limiting systems in the organism by telmisartan prescription may help to eliminate the adverse effects of hypercortisolemia on the progression of coronary artery disease, especially on the background of comorbid diabetes mellitus type 2 and anemia.
EPIDEMIOLOGY AND RISK FACTORS OF SUDDEN DEATH DUE TO PULMONARY THROMBOEMBOLISM: A RETROSPECTIVE STUDY
Authors: Šimakauskas Rokas , Baltuonis Martinas , Laima Sigitas , Chmieliauskas Sigitas , Fomin Dmitrij , Jasulaitis Algimantas , Stasiūnienė Jurgita 
Published: October 2019

Introduction. Pulmonary thromboembolism (PTE) is not an uncommon cause of sudden, unexpected death. Autopsy is the gold standard for cause of death determination in cases of suspected PTE. Mortality rates due to PTE are not estimated accurately.
Objective. The aim of this study was to analyze distribution patterns and risk factors of sudden deaths due to PTE.
Methods. Retrospective analysis of Lithuanian State Forensic Medicine Service autopsy data, period 2014-2018. A total of 4533 cases were reviewed; 80 cases met the criteria of immediate cause of death being PTE and were included in the study. PTE epidemiology, risk factors, clinical and pathoanatomical characteristics were described by reviewing scientific literature and statistical databases.
Results. PTE as the cause of sudden death was diagnosed in 37(46.25%) men and 43(53.75%) women. Median age at the time of death was 62.8±17.2 years. Death occurred in hospital in 21(26.25%) cases. Trauma was the underlying cause of PTE in 11(13.75%) cases; 9(81.8%) patients were admitted to hospital after a traumatic event. Cardiac hypertrophy was observed in 70(87.5%) autopsies. Abdominal subcutaneous fat thickness was 4.08±2.64 cm in men and 5.35±2.69 cm in women. Deep vein thrombosis (DVT) was confirmed upon microscopic examination in all cases, being the underlying cause of death in 67(83.75%) cases.
Conclusion. Sudden death due to PTE usually occurs at an older age and in absence of medical care. PTE is common after sustaining severe traumatic injuries which, when not immediately lethal, are managed in hospital. Cardiac hypertrophy and obesity may increase risk of death due to PTE. Undiagnosed and untreated DVT is often the underlying cause of sudden death due to PTE.
IMPACT OF PHYSICAL MUTAGENS ON THE MALE GAMETOPHYTE OF THE TEA PLANT FOR ITS FURTHER USE IN HYBRIDIZATION
Authors: Baratashvili Davit , Lomtatidze Nino , Dumbadze Guguli , Khalvashi Neli , Kedelidze Nino 
Published: October 2019

The migration of the radioisotopes - P32 and S35 from the soil to the tea plant (flowers) was studied. It is shown that their accumulation intensity in pollen sacs increases in proportion to the dose and reaches its maximum in the P32 variant after using a 8.0 MBq / ml dose. The migration intensity was the lowest in the 2.0 MBq / ml variant (0.14-0.223 MBq / 100 mg). It is estimated that P32 and S35 have significantly affected the vitality of tea plant pollens through the anomalies of their development. After using 2.0 and 4.0 MBq / ml doses, the vitality of the pollen is reduced in proportion to the dose and the development anomalies increase. Particulalry, the viability of pollen decrease compared to the control group, but the frequency and range of development anomalies increases. These include the slow development of the plant or the acceleration of the development of the primary nucleus, polyspermia, undeveloped pollen tube, etc. The use of processed P32 and S35 tea pollens in hybridization significantly increases the frequency of new formations and results in variability in the domination of signs. Among the new formations include the induction of haploids and triploids.
INFLUENСE OF SEASONAL FACTOR ON THE CHEMICAL COMPOSITION OF PERSIMMON
Authors: Bejanidze Irina , Kharebava Tina , Alasania Nargiz , Didmanidze Nato , Davitadze Nazi 
Published: October 2019

Persimmon is one of the most popular and favorite fruits not only in Georgia, but also in other countries. People love it for its unique specific taste and high nutritional value. There are more than 500 types of persimmon, properties and tastes which depend on the persimmon growing conditions.
The purpose of this project was to study the persimmon fruit chemical composition, the regularity in the quantity changes of the bioactive substances and technical-economical persimmon parameters during its storage and technological processing; to develop a highly profitable and efficient composite production technology for a new assortment of products and high quality beverages. Organoleptic and chemical tests of 12 persimmon fruit varieties were made. The content and composition of sugars, polyphenols, pectin, and tanning substances, were defined; and the relation of these parameters to the fruit maturity degree, the dynamics of their change in the ripening and storage process were determined. In addition, we determined the content of sugars ( inverted, total, saccharose), tanning substances (free, total), polyphenols and nitrogen through a spectrophotometric method, dry solids through a refractometric method, pectin (total, soluble, protopectin) and acidity through a potentiometric method, and cellulose through a chlorite method. The feasibility of the persimmon fruit industrial processing was established. Persimmon fruit of Khachia and Khiakume varieties were proved to be the best raw material for the industrial production of a fruit alcohol and beverages. It should be noted here that persimmon fruit must be harvested in November when they have a dark orange colouring and their dry solids content reaches 18%, inverted sugars make up 16-16.5%, and the acidity is 0.12%. For concentrate production, persimmon must be harvested in October when the fruit are yellow and their tanning and colouring substances reach 1.24%, and pectin substances make up 0.77%. The fruit sugars are glucose and fructose, generally in equal quantities. Tanning substances, leicoantocianes, in particular, are responsible for the tart taste; the lower their content is, the less the tart taste is felt, moreover, ripe fruit are less tart in flavour which is due to the tanning substances getting bound with high molecular substances. All the 12 persimmon varieties cultivated in Georgia can be used as raw material, including substandard and overripe fruit that are not marketable and do not have a long shelf life.
UTILIZATION OF BY-PRODUCTS GENERATED BY A WOOD GASIFICATION PLANT THROUGH ITS USE FOR THE RECLAMATION OF DISTURBED TERRAINS
Authors: Petrov Petar G. 
Published: October 2019

One of the biggest disturbances and pollutants of the environment occur due to the mining industry. For this reason, when talking about the restoration and recultivation of damaged lands and soils a recovery of the disturbed areas affected by mining activities should be first understood. Current waste management trends make us look for opportunities to recultivate disturbed mining areas by using waste or products that have the necessary properties and are a by-product (or waste) of industry. In this study, we have investigated, through laboratory methods, the possibility of using a by-product from a biomass gasification plant (FP) that potentially possesses the properties to improve soils quality during the reclamation process.
The paper analyzes the possibilities of using the FP by defining its effect on the soil forming process on disturbed sites, including: acidity, content of nutrients and mobility of heavy metals.
In order to determine the possibility of using the FP to enhance soils quality, in the experiment, we used soils that are going to be used for the reclamation of the Eastern embankment of the Ellatzite copper mine and by-product (FP), generated from a Biomass gasification plant located near the mine.
The territory that is possible to be reclaimed with FP is an embankment covered with rocks from the Ellatzite mine which has acidic reaction, high content of heavy metals and very low organic content. In general, conditions for land reclamation are severe and specific measures need to be implemented to achieve sustainable results.
CONTAMINATION OF SOILS BY HEAVY METALS AND THEIR INFLUENCE ON THE ENVIRONMENT IN BULGARIA
Authors: Petrova Tsvetelina , Simova Iskra , Pushkarov Martin , Velichkova Rositsa , Markov Detelin 
Published: October 2019

Heavy metals are one of the major pollutants. The main sources of pollution are industry, transport, the use of pesticides and mineral fertilizers in agriculture, the military industry, etc.
Pollution is mostly around businesses, highways and treated terrains and they are polymetallic, mostly from Cu, Pb, Zn, Cd, Hg, As and others.
In the current paper the main heavy metals for Bulgaria for the different sources of pollution are presented. An analysis of data for problem areas is made, according to sources of pollution. An analysis of the impact of pollutants on the environment is also conducted.
GRAPHICAL METHODS FOR NON-LINEAR ANALYSIS OF ELECTROCARDIOGRAPHIC DATA
Authors: Gospodinova Evgeniya 
Published: October 2019

INTRODUCTION: One of the most widely used methods for studying the bioelectric activity of the heart is the electrocardiogram (ECG). An important diagnostic parameter that can be determined by the ECG is heart rate variability (HRV), which takes into account the difference between successive strokes of the heart. Changing HRV can be an indicator of a number of disease states, such as low HRV levels can show poor health that is not only associated with cardiovascular disease but also with other diseases such as internal, nervous, mental, and other disorders.
OBJECTIVES: The subject of this article is the study of 24-hour ECG signals by applying non-linear graphical methods for HRV analysis. The non-linear graphical methods aim at obtaining graphical and quantitative information on the cardiovascular status of the study groups to complement the information obtained from traditional linear methods of analysis.
METHODS: For the non-linear analysis of HRV, graphical methods were used: Poincaré plot and Recurrence plot were used, which are suitable for the examination of electrocardiographic signals. Two groups of people were investigated: 20 healthy controls and 20 patients with arrhythmia.
RESULTS: Based on the nonlinear analysis of RR time series, the graphs of a healthy subject and a patient with arrhythmia were constructed using the Poincare plot. The graph of the healthy subject has the shape of a comet, while the graph of the patient with arrhythmia has the shape of a fan. The quantitative characteristics of patients with arrhythmia significantly change compared to the healthy subjects. The SD1 (p <0.003) and SD2 (p <0.0001) values decreased in patients with arrhythmia compared to the healthy controls. This reduction leads to reduction of the areas of the ellipse in the patients with arryhthmia. The ratio of SD1/SD2 (p <0.05) is lower for the healthy controls. The graphs obtained by the Recurrence plot of the investigated signals differ in healthy subjects and in patients with arrhythmia. For a healthy subject, the graph has a diagonal line and fewer squares showing a higher HRV. The graph of a patient with arrhythmia contains more squares, indicating periodicity in the investigated signal. The Recurrence Quantification Analysis showed that the values of the investigated parameters DET% (p <0.0001), REC% (p <0.0001) and ENTR (p <0.001) in patients with arrhythmia are increased.
CONCLUSIONS: The importance of the graphical nonlinear methods used for the analysis of HRV consists in forming a parametric and graphical assessment of the patient's health status.
An introduction to colonic polypectomy
Authors: Fawkes Jonathan 
Published: October 2019

Background: Colorectal cancer is the fourth most common cancer in the UK. The vast majority of colorectal cancers develop from polyps. Polypectomy is an endoscopic therapy that interrupts the sequence by which a polyp develops into cancer. Methods: A review was conducted of the published literature and clinical guidelines relevant to colonic polypectomy, with an aim to introduce basic concepts of colorectal polyp assessment and management and to describe potential complications of polypectomy. Findings: Through optical lesion assessment, it is possible to identify polyps with malignant potential. A number of techniques can be used to attempt removal, the goal of which is complete histological eradication in the safest way possible. Conclusion: Endoscopic polypectomy is a relatively safe intervention that is protective against colorectal cancer. Increasingly, nurses in the UK are being trained to perform polypectomy, particularly within the Bowel Scope service, which is part of the Bowel Cancer Screening Programme aimed at early diagnosis and removal of pre-cancerous, distal colorectal lesions.
Temporal changes in slipped upper femoral epiphysis at a regional level: A declining incidence and literature review
Authors: Tucker A. , Ballard J. , Cosgrove A. 
Published: October 2019

Purpose Slipped upper femoral epiphysis (SUFE) is one of the most common adolescent hip pathologies in children with potential for life-long morbidity secondary to avascular necrosis (AVN). The primary aim is to determine an up-to-date demographic of SUFE, as well as current trends in presentation and radiological characteristics. Secondary aims are to quantify prophylactic fixation and subsequent contralateral SUFE. Methods Between 01 January 2013 and 31 December 2015, all cases of SUFE were identified in Northern Ireland. Patient demographics, slip characteristics and outcomes are presented and the incidence rates were calculated using census data. Temporal changes in incidence, compared with a previous cohort, are demonstrated. Results A total of 56 patients (80 hips) were identified. Based on census data, SUFE incidence has declined from 7.14 to 4.69/100,000 population aged < 16 years. Male cases predominated by > 2:1 ratio, and tended to be older than female cases. Approximately 75% of patients were above the 75th centile for age-sex adjusted body weight. Knee pain as a presenting symptom led to a delay in diagnosis. Prophylactic fixation was performed in 25.9%, with contralateral slips occurring in 27.5%. AVN occurred in 7.4% and remained static. Conclusion The incidence of SUFE has declined ∼34% in our region. When SUFE occurs, knee pain often results in a delay in definitive diagnosis, and commands clinical vigilance to avoid delays in diagnosis. Patients in our region should be aware of a 1-in-4 contralateral slip rate. Overall, AVN rates remain static and are acceptable, despite the declining incidence of SUFE. Level of evidence Level III - Retrospective Cohort Study
Design and Field Test of a New Compact Self-Propelled Cabbage Harvester
Authors: Du Dongdong , Wang Jun , Xie Luxin , Deng Fanfei 
Published: October 2019

Abstract. As a labor-intensive operation, manual harvesting greatly affects cost and therefore profitability in the cabbage industry. A new compact self-propelled cabbage harvester for small, separate fields was designed and field tested. This harvester included a crawler chassis, a picking mechanism, a lifting mechanism, a cutting device, and a leaf separator. Results of preliminary field tests showed that the harvester had good flexibility and maneuverability. Results of field performance tests showed that the harvester could pick cabbages with diameters of 15 to 25 cm, providing a harvesting capacity of 0.21 hm2 h-1 and a harvest loss of 10.2%. Compared with experiments conducted in traditional fields, harvest quality showed an improvement in fields with an experimental cultivation method. The harvest loss was reduced by 5.0%, while the picking rate and accurate cutting rate were improved by 3.0% and 5.4%, respectively. Keywords: Cabbage, Compact, Field test, Mechanical harvester, Self-propelled.
In Conversation with Heidelise Als
Authors: Spence Kaye 
Published: October 2019

In May this year I had the opportunity to have a conversation with Dr. Heidelise Als in Auckland, New Zealand as she was the invited keynote speaker at the Council of International Neonatal Nurses (COINN) 10th international conference. It was such an honour to have her speak and network with over 400 neonatal nurses from 23 countries.
A Novice Trainer's Look: Shining Moments and Early Lessons Learned
Authors: Silberstein Dalia 
Published: October 2019

In this article I share my personal perspective on what NIDCAP training means to me. Not any training, but speciﬁcally that in which I became a NIDCAP trainer; in which my trainees and I did that very special journey for the ﬁrst time. The article does not bring an all-encompassing perspective of that experience, but rather a few salient revelations that became important lessons for me. It does not propose a generalizable view of what NIDCAP training is or should be, nor pretends to oﬀer clear-cut guidelines to the new Trainer. And yet, it might provide others the possibility to appraise and reﬂect on their own training experiences.
Advanced Practicum Experience: A Bitter Sweet Symphony
Authors: Nunezn Kristen James 
Published: October 2019

A component of NIDCAP training and the ﬁnal project prior to NIDCAP certiﬁcation, is the NIDCAP Advanced Practicum (AP). This involves following the journey of a newborn infant and their family through their NICU stay, completing systematic observations and formal write-ups of their progression. The provision of feedback to nursing, medical and allied health teams as well as the newborn’s family aims to support their growth and development in the NICU.
NIDCAP Training Centers Around the World: Australasian NIDCAP Training Centre- Sydney Australia
Authors: Spence Kaye 
Published: October 2019

In October 2017 we achieved our goal of becoming a NIDCAP Training Centre, this was nearly 20 years after Dr. Heidelise Als had come to Australia in 1998 to begin training in the Grace Centre for Newborn Care at the Children’s Hospital at Westmead in Sydney Australia. Over this time we changed trainers to Dr. Joy Browne in 2000 and we saw many nurses, neonatologists and occupational therapists commence training. In 2008 we had our ﬁrst successful NIDCAP Professionals. In 2017 we had our ﬁrst NIDCAP Trainer – Nadine Griﬃths.
Caracterização morfobiométrica de Senegalia bahiensis (Benth.) Seigler & Sbinger
Authors: Freitas Teresa Aparecida Soares de , Souza Thais Marcelo , Souza Leonardo Silva , Abdalla Samir Dutra , Souza Josival Santos 
Published: October 2019

Os objetivos foram descrever e ilustrar morfologicamente frutos, sementes e plântulas de Senegalia bahiensis, além de suas biometrias. Os frutos foram colhidos em árvores-matrizes no município de Castro Alves - BA - Brasil. As avaliações e observações foram feitas mediante uma amostragem aleatória de 100 frutos de cada matriz. Para o fruto avaliaram-se: tipo; cor; comprimento, largura, textura, número de sementes sadias e bem formadas por fruto e número de falsos septos. Sendo o comprimento mensurado com régua milimetrada e a largura foi medido com o auxílio de um paquímetro digital de precisão0,1 mm. As características biométricas e morfológicas das sementes observadas foram: cor, dimensão, forma, hilo, calaza, tegumento e embrião. O acompanhamento do desenvolvimento das plântulas foi realizado em casa de vegetação com sombrite 50%. Foi realizada a descrição das partes das plântulas, como: raiz, coleto, cotilédones hipocótilo, epicótilo, tipo de germinação, primeiro par de eófilos, além da tomada de comprimento da raiz primária, comprimento do hipocótilo e do epicótilo com auxílio de uma régua milimetrada. Os dados biométricos foram submetidos à análise descritiva calculando-se a média, máximo e mínimo, coeficiente de variação e erro padrão da média. Características dos frutos como sua deiscência, forma, coloração e sua textura; das sementes, como presença de pleurograma, calaza e posição do embrião; das plântulas como presença de estípulas interpeciolar e da filotaxia dos folíolulos, constituem-se como elementos que auxiliam para identificação da espécie no viveiro e em laboratório, como também no campo em trabalhos de regeneração natural.
Backbone dihedral angles prediction servers for protein early-stage structure prediction
Authors: Smolarczyk Tomasz , Stapor Katarzyna , Roterman-Konieczna Irena 
Published: October 2019

Abstract
Three-dimensional protein structure prediction is an important task in science at the intersection of biology, chemistry, and informatics, and it is crucial for determining the protein function. In the two-stage protein folding model, based on an early- and late-stage intermediates, we propose to use state-of-the-art secondary structure prediction servers for backbone dihedral angles prediction and devise an early-stage structure. Early-stage structures are used as a starting point for protein folding simulations, and any errors in this stage affect the final predictions. We have shown that modern secondary structure prediction servers could increase the accuracy of early-stage predictions compared to previously reported models.
Public Good Indices for Games with Several Levels of Approval
Authors: Courtin Sébastien , Tchantcho Bertrand 
Published: October 2019

Abstract
This work focuses on (j, 2) games in which there are several levels of approval in the input, i. e. games with n players, j ordered qualitative alternatives in the input level and 2 possible ordered quantitative alternatives in the output. When considering (j, 2) games, we extend the Public Good index (PGI), the Null Player Free index (NPFI) and the Shift index (SI) and provide full characterizations of these extensions.