bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook
Authors: Abdalla Gehad , Hammam Ahmed , Anjari Mustafa , D'Arco Dr. Felice , Bisdas Dr. Sotirios 
Published: June 2020

Inaccurate assessment of surveillance imaging to assess response to glioma therapy may have life-changing consequences. Varied management plans including chemotherapy, radiotherapy or immunotherapy may all contribute to heterogeneous post-treatment appearances and the overlap between the morphological features of pseudoprogression, pseudoresponse and radiation necrosis can make their discrimination very challenging. Therefore, there has been a drive to develop objective strategies for post-treatment assessment of brain gliomas. This review discusses the most important of these approaches such as the RANO “Response Assessment in Neuro-Oncology”, iRANO “Immunotherapy Response Assessment in Neuro-Oncology” and RAPNO “Response Assessment in Paediatric Neuro-Oncology” models. In addition to these systematic approaches for glioma surveillance, the relatively limited information provided by conventional imaging modalities alone has motivated the development of novel advanced magnetic resonance (MR) and metabolic imaging methods for further discrimination between viable tumour and treatment induced changes. Multiple clinical trials and meta-analyses have investigated the diagnostic performance of these novel techniques in the follow up of brain gliomas, including both single modality descriptive studies and comparative imaging assessment. In this manuscript, we review the literature and discuss the promises and pitfalls of frequently studied modalities in glioma surveillance imaging, including MR perfusion, MR diffusion and MR spectroscopy. In addition, we evaluate other promising MR techniques such as chemical exchange saturation transfer as well as fludeoxyglucose and non-FDG positron emission tomography techniques.
A Playground for ALL Children
Authors: Tavares M. C. 
Published: June 2020

As all children deserve the same opportunity to play with each other and to be happy in their differences, students from the class 3.ºB, of Santo Amaro Elementary School, want the school playground to be inclusive, for children in a wheelchair. At the beginning of the project, children in a wheelchair could not play together with their colleagues, as the playground equipment was not adapted. Students developed research on inclusion, built models, and contacted architects that are specialized in inclusive playgrounds. Students also engaged their families in the development of the project. The next step is to show the project to the local authorities.
The impact of large-scale deployment of Wolbachia mosquitoes on dengue and other Aedes-borne diseases in Rio de Janeiro and Niterói, Brazil: study protocol for a controlled interrupted time series analysis using routine disease surveillance data
Authors: Durovni Betina , Saraceni Valeria , Eppinghaus Ana , Riback Thais I.S. , Moreira Luciano A. , Jewell Nicholas P. , Dufault Suzanne M. , O'Neill Scott L. , Simmons Cameron P. , Tanamas Stephanie K. , Anders Katherine L. 
Published: June 2020

Background: Rio de Janeiro and Niterói are neighbouring cities in southeastern Brazil which experience large dengue epidemics every 2 to 5 years, with >100,000 cases notified in epidemic years. Costs of vector control and direct and indirect costs due to the Aedes-borne diseases dengue, chikungunya and Zika were estimated to total $650 million USD in 2016, but traditional vector control strategies have not been effective in preventing mosquito-borne disease outbreaks. The Wolbachia method is a novel and self-sustaining approach for the biological control of Aedes-borne diseases, in which the transmission potential of Aedes aegypti mosquitoes is reduced by stably transfecting them with the Wolbachia bacterium (wMel strain). This paper describes a study protocol for evaluating the effect of large-scale non-randomised releases of Wolbachia­-infected mosquitoes on the incidence of dengue, Zika and chikungunya in the two cities of Niterói and Rio de Janeiro. This follows a lead-in period since 2014 involving intensive community engagement, regulatory and public approval, entomological surveys, and small-scale pilot releases. Method: The Wolbachia releases during 2017-2019 covered a combined area of 170 km2 with a resident population of 1.2 million, across Niterói and Rio de Janeiro. Untreated areas with comparable historical dengue profiles and demographic characteristics have been identified a priori as comparative control areas in each city. The proposed pragmatic epidemiological approach combines a controlled interrupted time series analysis of routinely notified suspected and laboratory-confirmed dengue and chikungunya cases, together with monitoring of Aedes-borne disease activity utilising outbreak signals routinely used in public health disease surveillance. Discussion: If the current project is successful, this model for control of mosquito-borne disease through Wolbachia releases can be expanded nationally and regionally.
Glycemic control monitoring in patients with tuberculosis and diabetes: a descriptive study from programmatic setting in Tamil Nadu, India
Authors: Gurukartick J. , Murali Lakshmi , Shewade Hemant Deepak , Jacob Anil G. , Samy M. M. , Dheenadayal D. , Aslesh O. P. , Marimuthu Ganesh , Ananthakrishnan Ramya , Krishnan Nalini 
Published: June 2020

Background: India’s national tuberculosis (TB) programme recommends that among patients with diabetes mellitus and TB, fasting blood glucose (FBG) be recorded at baseline, the end of intensive phase and the end of continuation phase of TB treatment. We conducted this operational research in select districts of Tamil Nadu, India, in 2016 to determine the availability of blood glucose records and glycemic control status during TB treatment. Methods: This was a descriptive study involving secondary programme data. Glycemic control during TB treatment was ‘optimal’ if both baseline and end of intensive phase FBG (during TB treatment) were <130 mg/dl. In the absence of FBG, we used random blood glucose (RBG), with <180 mg/dl as the cut off. Results: Of 438 patients, FBG at baseline, the end of intensive phase and the end of continuation phase were each available in <20%. Glycemic control status was known for 94% (412/438) patients at baseline and for 91% (400/438) during TB treatment. Among those with known glycemic status, glycemic control was not optimal in 77% of patients (316/412) at baseline and in 84% (337/400) during TB treatment. The proportion of patients with unfavourable TB treatment outcomes at the end of intensive phase was 11% (46/438) and at the end of continuation phase was 5% (21/438). We decided against assessing factors associated with glycemic control during TB treatment and association between glycemic control and TB treatment outcomes because glycemic control assessment, if any, was based mostly on RBG values. Conclusion: Among patients with diabetes and tuberculosis, recording of FBG during tuberculosis treatment requires urgent attention.
Parafunctions, Signs and Symptoms of Temporomandibular Disorders (TMD), in Children with Attention-Deficit Hyperactivity Disorder (ADHD).
Authors: Suligowska Klaudia , Mikietyńska Magdalena , Pakalska-Korcala Anna , Wolańczyk Tomasz , Prośba-Mackiewicz Maria , Zdrojewski Tomasz 
Published: June 2020

Cel pracyCelem pracy było porównanie ilości parafunkcji oraz oznak i objawów TMD w populacyjnej grupie dzieci z ADHD i bez ADHD.MetodaBadaniem objęto wszystkie dzieci klas V wszystkich publicznych szkół podstawowych (dzieci nieleczone, niekierowane). Zgłaszalność wyniosła 91%.
W I etapie badań psychologiczno-psychiatrycznych rodzice i dzieci wypełniali kwestionariusze CBCL i YSR. W kolejnym etapie u dzieci wyłonionych w badaniu przesiewowym wykwalifikowany psychiatra dziecięcy przeprowadził półustrukturyzowany wywiad diagnostyczny K-SADS-PL i diagnozował ADHD. Parafunkcje, oznaki i objawy TMD oceniono przeprowadzając bezpośredni wywiad z dzieckiem oraz badanie kliniczne przez lekarza stomatologa.WynikiWykazano istotne różnice (p<0,05) pomiędzy dziećmi z ADHD i bez ADHD związane z uprawianiem parafunkcji takich jak: żucie gumy (76,47% vs. 46,07%), obgryzanie paznokci (70,59% vs. 40,45%) oraz bruksizm (52,54% vs. 26,22%), liczbą uprawianych parafunkcji (8-10 parafunkcji 11,76% vs. 2,25%) oraz oznak i objawów TMD (1 oznaka lub objaw 0,0% vs 32,21%; 4-7 oznak lub objawów 17,65% vs. 3,75%).WnioskiU dzieci z ADHD wykazano znacznie częstsze występowanie objawów zaburzeń stawu skroniowo-żuchwowego oraz uprawianych parafunkcji. Badania te sugerują, że dzieci z ADHD stanowią grupę zwiększonego ryzyka wystąpienia TMD w przyszłości. Koniecznie jest interdyscyplinarne leczenie pacjenta z ADHD przez psychiatrę i stomatologa.
The Influence of Performance Measurement on the Processual Dynamics of Strategic Change
Authors: Abernethy Margaret A. , Dekker Henri C. , Grafton Jennifer 
Published: June 2020

We draw on a five-year longitudinal data set to investigate the influence of performance measurement in the processual dynamics of strategic change, particularly in enacting effective strategic change. Our model examines the role of performance measurement in driving strategy-consistent operational changes and in ensuring that the desired objectives of the strategic change process are achieved. We investigate these roles for performance measurement over time and empirically document lags between changes in strategic priorities, changes in operational processes, and subsequent changes in firm performance. We find that performance measurement supports the implementation of strategic change by influencing the extent to which changes to operational tasks and activities are made in response to new strategic priorities, as well as influencing the quality and impact of these operational changes, as reflected in improved contemporaneous and future firm performance. This paper was accepted by Suraj Srinivasan, accounting.
Limb position influences component orientation in Oxford mobile bearing unicompartmental knee arthroplasty
Authors: Tapasvi Sachin , Shekhar Anshu , Patil Shantanu , Pandit Hemant 
Published: June 2020

Aims The mobile bearing Oxford unicompartmental knee arthroplasty (OUKA) is recommended to be performed with the leg in the hanging leg (HL) position, and the thigh placed in a stirrup. This comparative cadaveric study assesses implant positioning and intraoperative kinematics of OUKA implanted either in the HL position or in the supine leg (SL) position. Methods A total of 16 fresh-frozen knees in eight human cadavers, without macroscopic anatomical defects, were selected. The knees from each cadaver were randomized to have the OUKA implanted in the HL or SL position. Results Tibial base plate rotation was significantly more variable in the SL group with 75% of tibiae mal-rotated. Multivariate analysis of navigation data found no difference based on all kinematic parameters across the range of motion (ROM). However, area under the curve analysis showed that knees placed in the HL position had much smaller differences between the pre- and post-surgery conditions for kinematics mean values across the entire ROM. Conclusion The sagittal tibia cut, not dependent on standard instrumentation, determines the tibial component rotation. The HL position improves accuracy of this step compared to the SL position, probably due to better visuospatial orientation of the hip and knee to the surgeon. The HL position is better for replicating native kinematics of the knee as shown by the area under the curve analysis. In the supine knee position, care must be taken during the sagittal tibia cut, while checking flexion balance and when sizing the tibial component.
MEMBACA KISAH NABI DAUD MENGGUNAKAN SEMIOTIKA ROLAND BARTHES
Authors: Santoso Jarot Nanang , Abror Indal 
Published: June 2020

Roland Barthes’s semiotics, as a science that is concerned in coding, was applied in analyzing the story of the Prophet David. Application of multilevel readings; Heuristic readings and retroactive readings in the story of the Prophet David consisting of 25 lexia texts of the Koran, were found to be of significance identified from certain codes, including: a) hermeunetic code / puzzle code, b) symbolic code “David” symbol from the ideal leader, c) the semic code or the “ark” connotative code means the importance of preserving and preserving relics, d) the proaretic code / action code “David fell” means humility acknowledging mistakes not looking at someone’s status, e) gnomic code or code Cultural “Goliath and its troops” means that there will always be those who spread damage, and during this time God’s intervention will also contribute to protecting the universe through the other party who spread goodness, and so on.
MAHABBAH DAN MA’RIFAH DALAM TASAWUF DZUNNUN AL-MISHRI
Authors: Wati Mina 
Published: June 2020

This article discusses mahabbah (the love of beings to God) and ma’rifah (the blessing of God to beings) that focuses on the thought of Dzunnun al-Mishri (hereinafter referred to as Dzunnun). The insufficiency of research on mahabbah and ma’rifah is the main reason for the requirement for further research related to the character and the relationship between this two concepts. So far, when talking about mahabbah, the most popular name is Rabiah al-Adawiyah. It is necessary to discuss about mahabbah and ma’rifah in the frame of thought of Dzunnun being resurrected. In addition, in this day and age, it is necessary for humankind to explore the concepts offered by Dzunnun given the many global impediment that cause humanity to drought in spirituality. This article is based on library or library research that examines library data by using descriptive analysis, interpretation and data analysis methods. The source used is secondary data which is used as a support for writing this article. The approach of Sufism with the general method of the Sufis is a prominent feature in the writing of this article. Ma’rifah is the highest level in the application of Sufism that can be achieved with Mahabbah. Every human being can do and feel mahabbah because in essence mahabbah creates servant’s love for the Creator. Meanwhile, ma’rifah is knowing or knowing God so that his heart can see God and he feels close to God. The relationship between the two can be said with the sentence, “love grows because of knowledge and cognition of God.” From that sentence, it can be seen that there is a correlation between mahabbah and ma’rifah. Ma’rifah can be obtained if humans have traced and felt mahabbah. Mahabbah is a feeling of closeness to God through love (spirit). Meanwhile, ma’rifah is the level of knowledge to God through the eyes of the heart (al-Qalb).
Electroacupuncture ameliorates post-traumatic stress disorder in rats via a mechanism involving the BDNF-TrkB signaling pathway
Authors: Li Mi , Xie Yiqiang , Niu Kun , Li Kai 
Published: June 2020

Post-traumatic stress disorder (PTSD) is a mental health condition triggered by a terrifying event, causing flashbacks, nightmares and severe anxiety. It develops in individuals who have experienced a shocking, scary, or dangerous event. Electroacupuncture is reported to be effective for the treatment of PTSD. The present study was carried out to investigate the protective effect of electroacupuncture in a rat model of PTSD, and the mechanism involved. Specific-pathogen-free male Sprague Dawley rats (n = 30) weighing 180 – 220 g (mean weight = 200 ± 20 g) were randomly assigned to three groups of ten rats each: control group, single-prolonged stress (SPS) group, and treatment group. The treatment group rats received electroacupuncture. Changes in PTSD-like behavior were assessed using locomotor activity, elevated plus-maze (EPM) and fear conditioning tests. The mRNA and protein expressions of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) were determined using real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting, respectively. Co-immunoprecipitation (Co-IP) was used to measure BDNF and TrkB binding interaction, while chromatin immunoprecipitation (ChIP) was used to evaluate the binding between cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) and its target genes. Electroacupuncture significantly increased locomotor activity and exploratory behavior, but significantly reduced general fear and anxiety in SPS rats (p < 0.05). It also significantly upregulated the mRNA and protein expressions of BDNF and TrkB, and increased the binding of BDNF to its receptor TrkB (p < 0.05). Electroacupuncture significantly increased the binding of CREB to BDNF promoter region (p < 0.05). Electroacupuncture ameliorates PTSD in rats via a mechanism involving the BDNF-TrkB signaling pathway.
Finite-difference equations of quasistatic motion of the shallow concrete shells in nonlinear setting
Authors: Duissenbekov Bolat , Tokmuratov Abduhalyk , Zhangabay Nurlan , Orazbayev Zhenis , Yerimbetov Baisbay , Aldiyarov Zhumadilla 
Published: June 2020

AbstractThe study solves a system of finite difference equations for flexible shallow concrete shells while taking into account the nonlinear deformations. All stiffness properties of the shell are taken as variables,i.e., stiffness surface and through-thickness stiffness. Differential equations under consideration were evaluated in the form of algebraic equations with the finite element method. For a reinforced shell, a system of 98 equations on a 8×8 grid was established, which was next solved with the approximation method from the nonlinear plasticity theory. A test case involved computing a 1×1 shallow shell taking into account the nonlinear properties of concrete. With nonlinear equations for the concrete creep taken as constitutive, equations for the quasi-static shell motion under constant load were derived. The resultant equations were written in a differential form and the problem of solving these differential equations was then reduced to the solving of the Cauchy problem. The numerical solution to this problem allows describing the stress-strain state of the shell at each point of the shell grid within a specified time interval.
On soft pc-separation axioms
Authors: Hamko Qumri H. , Ahmed Nehmat K. , Khalaf Alias B. 
Published: June 2020

AbstractMany mathematicians defined and studied soft separation axioms and soft continuity in soft spaces by using ordinary points of a topological spaceX. Also, some of them studied the same concepts by using soft points. In this paper, we introduce the concepts of soft{p}_{c}-{T}_{i}and soft{p}_{c}-{T}_{i}^{\ast },i=0,1,2by using the concept of soft{p}_{c}-open sets in soft topological spaces. We explore several properties of such spaces. We also investigate the relationship among these spaces and provide a counter example when it is needed.
Investment Boolean problem with Savage risk criteria under uncertainty
Authors: Bukhtoyarov Sergei E. , Emelichev Vladimir A. 
Published: June 2020

AbstractThe portfolio theory is used to formulate a multicriteria investment Boolean escaped gain minimization problem for searching all extreme portfolios. Stability aspects of this set against perturbed parameters of minimax Savage criteria are studied. We give lower and upper estimates for the stability radius for arbitrary Hölder norms on the three-dimensional space of initial data.
Knowledge and awareness of individual sickle cell genotype among adolescents in a unity school in Southeast, Nigeria: a cross-sectional study
Authors: Ezenwosu Osita U. , Chukwu Barthlomew F. , Ezenwosu Ifeyinwa L. , Ikefuna Anthony N. , Emodi Ifeoma J. , Ezeanolue Echezona E. 
Published: June 2020

Abstract

Objective
Our study sought to assesses the knowledge and awareness of individual sickle cell genotype among adolescents.

Methods
Participants were recruited from a large school in Southeast Nigeria where adult prevalence of sickle cell trait is 25%. Data was collected through a 50-item survey with previously pretested questions that assessed awareness of individual genotype, general knowledge of sickle cell disease, perception of sickle cell trait and sickle cell anaemia (SCA). Additionally, self-reported genotype was compared to the school’s admission records to determine accuracy of self-reported genotype. The knowledge scores were summed on a binary basis with one point assigned for a correct answer while zero was given for an incorrect response.

Results
Four hundred and nine (409) students were approached and enrolled in the study. A vast majority (94%) of the respondents reported being aware of their genotype and two-thirds had the awareness during school admission. However, in specific knowledge of sickle cell, majority (89.7%) of the participants miscalculated the probability of having a child with SCA in married carrier couple and 71.9% misidentified the proportion of Nigerians with sickle cell trait. Assessing level of knowledge of sickle cell, only very few of the adolescents (7.3%) were found with the expected high knowledge scores of 7–8.

Conclusion
Although a significant proportion of respondents were aware of their genotype, most were unaware of the implications of sickle cell trait and thought that people with sickle cell trait also have symptoms of sickle cell disease. Also, only a few of the respondents have the expected level of sickle cell knowledge. A focused educational intervention among this age group is crucial as they embark on making reproductive health decisions.
On the topology of geometric and rational orbits for algebraic group actions over valued fields
Authors: Dao Phuong Bac 
Published: June 2020

Abstract
In this note, we study the relationship between Zariski and relative closedness for actions of (smooth) algebraic groups defined over valued (mainly local) fields of any characteristic.
In particular, we use some recent basic results regarding the completely reducible subgroups and cocharacter-closedness due to Bate–Herpel–Röhrle–Tange and Uchiyama to construct some actions of simple algebraic groups G of the types

D
4

{D_{4}}

,

E
6

{E_{6}}

,

E
7

{E_{7}}

,

E
8

{E_{8}}

,

G
2

{G_{2}}

on an affine variety defined over a local function field k, and

v
∈

V
⁢

(
k
)

{v\in V(k)}

such that the geometric orbit

G
.
v

{G.v}

is Zariski closed although the corresponding relative orbit

G
⁢

(
k
)

.
v

{G(k).v}

is not closed in the topology induced from k.
Besides, by using an interesting result due to Gabber, Gille and Moret-Bailly, we show that this phenomenon does not appear when we consider the action of either a smooth unipotent group or a smooth commutative algebraic group, defined over an admissible valued (e.g., local) field.
When a locally compact monothetic semigroup is compact
Authors: Zelenyuk Yevhen , Zelenyuk Yuliya 
Published: June 2020

Abstract
A semigroup endowed with a topology is monothetic if it contains a dense monogenic subsemigroup.
A semigroup (group) endowed with a topology is semitopological (quasitopological) if the translations (the translations and the inversion) are continuous.
If S is a nondiscrete monothetic semitopological semigroup, then the set

S
′

{S^{\prime}}

of all limit points of S is a closed ideal of S.
Let S be a locally compact nondiscrete monothetic semitopological semigroup.
We show that (1) if the translations of

S
′

{S^{\prime}}

are open, then

S
′

{S^{\prime}}

is compact, and (2) if

S
′

{S^{\prime}}

can be topologically and algebraically embedded in a quasitopological group, then

S
′

{S^{\prime}}

is a compact topological group.