bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic study of Galactic infrared bubbles along the Galactic plane with AKARI and Herschel. II. Spatial distributions of dust components around the bubbles
Authors: Hanaoka Misaki , Kaneda Hidehiro , Suzuki Toyoaki , Kokusho Takuma , Oyabu Shinki , Ishihara Daisuke , Kohno Mikito , Furuta Takuya , Tsuchikawa Takuro , Saito Futoshi 
Published: October 2019

Abstract
Galactic infrared (IR) bubbles, which can be seen as shell-like structures at mid-IR wavelengths, are known to possess massive stars within their shell boundaries. In our previous study (Hanaoka, 2019, PASJ, 71, 6), we expanded the research area to the whole Galactic plane ($0^{\circ } \le l \le 360^{\circ }$, $|b| \le 5^{\circ }$) and studied systematic differences in the shell morphology and the IR luminosity of the IR bubbles between inner and outer Galactic regions. In this study, utilizing high spatial-resolution data of AKARI and WISE in the mid-IR and Herschel in the far-IR, we investigate the spatial distributions of dust components around each IR bubble to discuss the relation between the star-formation activity and the dust properties of the IR bubbles. For the 247 IR bubbles studied in Hanaoka (2019, PASJ, 71, 6), 165 IR bubbles are investigated in this study, which have the Herschel data ($|b|\le 1^{\circ }$) and known distances. We created their spectral energy distributions on a pixel-by-pixel basis around each IR bubble, and decomposed them with a dust model consisting of polycyclic aromatic hydrocarbons (PAHs), hot dust, warm dust and cold dust. As a result, we find that the offsets of dust heating sources from the shell centers in inner Galactic regions are systematically larger than those in outer Galactic regions. Many of the broken bubbles in inner Galactic regions show large angles between the offset and the direction of the broken shell from the center. Moreover, the spatial variations of the PAH intensity and cold dust emissivity around the IR bubbles in inner Galactic regions are larger than those in outer Galactic regions. We discuss these results in light of the interstellar environments and the formation mechanism of the massive stars associated with the IR bubbles.
CsMYB3 and CsRuby1 form an ‘Activator-and-Repressor’ Loop for the Regulation of Anthocyanin Biosynthesis in Citrus
Authors: Huang Ding , Tang Zhouzhou , Fu Jialing , Yuan Yue , Deng Xiuxin , Xu Qiang 
Published: October 2019

Abstract
Anthocyanins are preferentially accumulated in certain tissues of particular species of citrus. A R2R3-MYB transcription factor (named Ruby1) has been well documented as an activator of citrus anthocyanin biosynthesis. In this study, we characterized CsMYB3, a transcriptional repressor that regulates anthocyanin biosynthesis in citrus. CsMYB3 was expressed in anthocyanin-pigmented tissues, and the expression was closely associated with that of Ruby1, which is a key anthocyanin activator. Overexpression of CsMYB3 in Arabidopsis resulted in a decrease in anthocyanins under nitrogen stress. Overexpression of CsMYB3 in the background of CsRuby1-overexpressing strawberry and Arabidopsis reduced the anthocyanin accumulation level. Transient promoter activation assays revealed that CsMYB3 could repress the activation capacity of the complex formed by CsRuby1/CsbHLH1 for the anthocyanin biosynthetic genes. Moreover, CsMYB3 could be transcriptionally activated by CsRuby1 via promoter binding, thus forming an ‘activator-and-repressor’ loop to regulate anthocyanin biosynthesis in citrus. This study shows that CsMYB3 plays a repressor role in the regulation of anthocyanin biosynthesis and proposes an ‘activator-and-repressor’ loop model constituted by CsRuby1 and CsMYB3 in the regulation of anthocyanin biosynthesis in citrus.
Stock Market Rumors and Credibility
Authors: Schmidt Daniel 
Published: October 2019

Abstract
Stock prices occasionally move in response to unverified rumors. I propose a cheap talk model in which a rumormonger’s incentives to tell the truth depend on the interaction between her investment horizon and the information acquisition decisions of message-receiving investors. The model’s key prediction is that short investment horizons can facilitate credible information sharing between investors, thereby accelerating the information capitalization into market prices. Analyzing a data set of takeover rumors covered by U.S. newspapers, I find suggestive evidence in support of this prediction.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Delineating the social valuation network in adolescents
Authors: Kumar Poornima , Pisoni Angela , Bondy Erin , Kremens Rebecca , Singleton Paris , Pizzagalli Diego A , Auerbach Randy P 
Published: October 2019

Abstract
Adolescents strive for peer approval, and an increased sensitivity to peers’ opinions is normative. However, among vulnerable adolescents, peer evaluation can be detrimental, contributing to affective disorders. It is, therefore, critical to improve our understanding of neural underpinnings of peer evaluation. Prior research has investigated averaged neural responses to peer acceptance or rejection, neglecting to probe trial-by-trial computations that mirror real-time updating of daily activities. In non-social decision-making, a common neural valuation system centered on the medial prefrontal cortex (mPFC) has emerged, which evaluates different reward types on a common scale to guide choices. However, it is unclear whether the mPFC also tracks complex social scenarios involving peer feedback. To address this gap, we acquired fMRI data from 55 healthy adolescents during the Chatroom Task, which probes peer evaluation, and implemented a computational approach to characterize trial-by-trial social value, thereby allowing us to interrogate the neural correlates of social value. Consistent with our hypothesis, social value signals were encoded in the mPFC. Interestingly, analyses also revealed a wider social-specific valuation network including the precuneus and amygdala. Understanding how adolescents make social decisions and neural markers associated with it, may, ultimately, help us clarify promising targets for intervention.
A Network Analysis of Epigenetic and Transcriptional Regulation in a Neurodevelopmental Rat Model of Schizophrenia With Implications for Translational Research
Authors: Du Yang , Li Xue-Song , Chen Lei , Chen Guang-Yang , Cheng Yong 
Published: October 2019

Abstract
Prenatal administration of mitotoxin methylazoxymethanol acetate (MAM) in rats produces behavioral, pharmacological, and anatomical abnormalities once offspring reach adulthood, thus establishing a widely used neurodevelopmental model of schizophrenia. However, the molecular aspects underlying this disease model are not well understood. Therefore, this study examines epigenetic and transcriptional dysregulation in the prefrontal cortex and hippocampus of MAM rats as these are brain regions closely associated with schizophrenia pathogenesis. Upon sequencing messenger and microRNA (mRNA and miRNA, respectively), differential expression was revealed in the prefrontal cortex and hippocampus between MAM- and saline-treated rats; sequencing data were validated by qualitative real-time polymerase chain reaction. Bioinformatic analyses demonstrated that the differentially expressed (DE) genes were strongly enriched in interactive pathways related to schizophrenia, including chemical synaptic transmission, cognition, and inflammatory responses; also, the potential target genes of the DE miRNAs were enriched in pathways related to synapses and inflammation. The blood of schizophrenia patients and healthy controls was further analyzed for several top DE mRNAs: DOPA decarboxylase, ret proto-oncogene, Fc receptor-like 2, interferon lambda receptor 1, and myxovirus (influenza virus) resistance 2. The results demonstrated that the expression of these genes was dysregulated in patients with schizophrenia; combining these mRNAs sufficiently differentiated schizophrenia patients from controls. Taken together, this study suggests that the MAM model has the potential to reproduce hippocampus and prefrontal cortex abnormalities, relevant to schizophrenia, at the epigenetic and transcriptional levels. These data also provide novel targets for schizophrenia diagnoses and treatments.
How does policy focus influence scientific research?
Authors: Kishi Naoko 
Published: October 2019

Abstract
Policy focus gives scientists an incentive to pursue specific research subjects and influences a trend of scientific research. This study examines how public grant is allocated for stem cell research in Japan and shows that scientists are likely to advance their research toward the direction led by policy. Since Japanese scientists discovered a method to generate induced pluripotent stem cell (iPSC) in 2006, public financial and institutional support has skewed toward iPSC. The 2012 Nobel Prize in Physiology or Medicine for iPSC has also had an impact on policy and scientists’ selection of stem cells. Scientists in the top universities are likely to select iPSC research. In addition, iPSC research obtains more amount of public grant funding than other stem cell research. However, scientists’ age has no relevant impact on selecting iPSC research. Finally, this study concludes that targeted public funding skews knowledge portfolio by scientists in a nascent field.
The costs of successful beneficiaries in proceedings brought under section 50 of the Administration of Justice Act 1985—Perry v Neupert
Authors: Grantham Andrew 
Published: October 2019

Abstract
In this article, Andrew Grantham reviews the recent decision of the Court in Perry v Neupert in which HHJ Eyre QC reviewed the entitlement of successful beneficiaries to recover their costs in proceedings to remove the executor named in the testator’s will and the extent to which in such circumstances the executor is entitled to an indemnity out of the assets of the estate.
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations
Authors: Vazquez Joel H , Clemens Melissa M , Allard Felicia D , Yee Eric U , Kennon-McGill Stefanie , Mackintosh Samuel G , Jaeschke Hartmut , Hambuchen Michael D , McGill Mitchell R 
Published: October 2019

Abstract
The standard circulating biomarker of liver injury in both clinical settings and drug safety testing is alanine aminotransferase (ALT). However, ALT elevations sometimes lack specificity for tissue damage. To identify novel serum biomarkers with greater specificity for injury, we combined unique animal models with untargeted proteomics, followed by confirmation with immunoblotting. Using proteomics, we identified 109 proteins in serum from mice with acetaminophen (APAP)-induced liver injury that were not detectable in serum from mice with benign ALT elevations due to high-dose dexamethasone (Dex). We selected 4 (alcohol dehydrogenase 1A1 [Aldh1a1], aldehyde dehydrogenase 1 [Adh1], argininosuccinate synthetase 1 [Ass1], and adenosylhomocysteinase [Ahcy]) with high levels for further evaluation. Importantly, all 4 were specific for injury when using immunoblots to compare serum from Dex-treated mice and mice with similar lower ALT elevations due to milder models of APAP or bromobenzene-induced liver injury. Immunoblotting for ALDH1A1, ADH1, and ASS1 in serum from APAP overdose patients without liver injury and APAP overdose patients with mild liver injury revealed that these candidate biomarkers can be detected in humans with moderate liver injury as well. Interestingly, further experiments with serum from rats with bile duct ligation-induced liver disease indicated that Aldh1a1 and Adh1 are not detectable in serum in cholestasis and may therefore be specific for hepatocellular injury and possibly even drug-induced liver injury, in particular. Overall, our results strongly indicate that ALDH1A1, ADH1, and ASS1 are promising specific biomarkers for liver injury. Adoption of these biomarkers could improve preapproval drug safety assessment.
The role of prison-based interventions for hepatitis C virus (HCV) micro-elimination among people who inject drugs in Montréal, Canada
Authors: Godin Arnaud , Kronfli Nadine , Cox Joseph , Alary Michel , Maheu-Giroux Mathieu 
Published: October 2019

AbstractBackgroundIn Canada, hepatitis C virus (HCV) transmission primarily occurs among people who inject drugs (PWID) and people with experience in the prison system bare a disproportionate HCV burden. These overlapping groups of individuals have been identified as a priority populations for HCV micro-elimination in Canada, a country currently not on track to achieve its elimination targets. Considering the missed opportunities to intervene in provincial prisons, this study aims to estimate the population-level impact of prison-based interventions and post-release risk reduction strategies on HCV transmission among PWID in high HCV-burdened Canadian city, Montréal.MethodsA dynamic HCV transmission model among PWID was developed and calibrated to community and prison bio-behavioural surveys in Montréal. The, the relative impact of prison-based testing and treatment or post-release linkage to care, alone or in combination with risk reduction strategies, was estimated from 2018 to 2030, and compared to counterfactual status quo scenario.ResultsTesting and linkage to care interventions implemented over 2018-30 could lead to the greatest declines in prevalence (23%; 95% Credible interval(CrI):17–31%), incidence (20%; 95%CrI: 10–28%), and prevent the most new chronic infections (8%; 95%CrI: 4–11%). Testing and treatment in prison could decrease prevalence, incidence, and fraction of prevented new chronic infections. Combining test and linkage to care with risk reduction measures could further its epidemiological impact, preventing 10% (95%CrI: 5–16%) of new chronic infections. When implemented concomitantly with community-based treatment scale-up, both prison-based interventions had synergistic effects, averting a higher fraction of new chronic infections.ConclusionOffering HCV testing and post-release linkage to care in provincial prisons, where incarcerations are frequent and sentences short, could change the course of the HCV epidemic in Montréal. Integration of post-release risk reduction measures and community-based treatment scale-up could also increase the impact of these interventions.
Spatial versus angular resolution for tractography-assisted planning of deep brain stimulation
Authors: Liebrand Luka C. , van Wingen Guido A. , Vos Frans M. , Denys Damiaan , Caan Matthan W.A. 
Published: October 2019

AbstractGiven the restricted total scanning time for clinical neuroimaging, it is unclear whether clinical diffusion MRI protocols would benefit more from higher spatial resolution or higher angular resolution. In this work, we investigated the relative benefit of improving spatial or angular resolution in diffusion MRI to separate two parallel running white matter tracts that are targets for deep brain stimulation: the anterior thalamic radiation and the supero-lateral branch of the medial forebrain bundle. Both these tracts are situated in the ventral anterior limb of the internal capsule, and recent studies suggest that targeting a specific tract could improve treatment efficacy. Therefore, we scanned 19 healthy volunteers at 3T and 7T according to three diffusion MRI protocols with respectively standard clinical settings, increased spatial resolution of 1.4 mm, and increased angular resolution (64 additional gradient directions at b=2200s/mm2). We performed probabilistic tractography for all protocols and quantified the separability of both tracts. The higher spatial resolution protocol improved separability by 41% with respect to the clinical standard, presumably due to decreased partial voluming. The higher angular resolution protocol resulted in increased apparent tract volumes and overlap, which is disadvantageous for application in precise treatment planning. We thus recommend to increase the spatial resolution for deep brain stimulation planning to 1.4 mm while maintaining angular resolution. This recommendation complements the general advice to aim for high angular resolution to resolve crossing fibers, confirming that the specific application and anatomical considerations are leading in clinical diffusion MRI protocol optimization.
A Comprehensive Typing System for Information Extraction from Clinical Narratives
Authors: Caufield J. Harry , Zhou Yichao , Bai Yunsheng , Liem David A. , Garlid Anders O. , Chang Kai-Wei , Sun Yizhou , Ping Peipei , Wang Wei 
Published: October 2019

AbstractWe have developed ACROBAT (Annotation for Case Reports using Open Biomedical Annotation Terms), a typing system for detailed information extraction from clinical text. This resource supports detailed identification and categorization of entities, events, and relations within clinical text documents, including clincal case reports (CCRs) and the free-text components of electronic health records. Using ACROBAT and the text of 200 CCRs, we annotated a wide variety of real-world clinical disease presentations. The resulting dataset, MACCROBAT2018, is a rich collection of annotated clinical language appropriate for training biomedical natural language processing systems.
Evaluation of a brief intervention to reduce cell phone use in college students
Authors: Piper Brian J. , Daily Shay M. , Martin Sarah L. , Martin Maurice W. 
Published: October 2019

AbstractBackgroundExcessive cell phone use contributes to distracted driving, may increase risk for automobile accidents, and a minority of mobile phone users exhibit behaviors consistent with technological addiction. The purpose of this study was to determine whether cell phone beliefs and behaviors could be changed by a brief educational encounter. The Theory of Reasoned Action provided a lens for viewing attitudes and behavior.MethodsA one-week pre-post design with a thirty-day follow-up was used with participants (N = 215, 67.0% female, age = 20.0 + 1.6) assigned to a peer led intervention or comparison groups. The intervention included cell-phone educational materials. A short index of cell phone behavior was developed which showed good internal consistency with a Cronbach’s alpha of .81.ResultsThe intervention group “agreed” or “strongly-agreed” more than the comparison group on five of the seven areas of cell phone beliefs and behaviors (p < 0.05, item Cohen’s d = .32 to .47, total d = .50) at one-week following receipt of informational materials.DiscussionWe conclude that attitudes and behaviors regarding cell phones are malleable and susceptible to change in young-adults following a brief psychoeducational intervention.
Increased Mortality in Patients with Standard EEG Findings of “Diffuse Slowing”
Authors: Wanzek Rob , Bormann Nicholas , Shabbir Yaseen , Saito Taku , Yamada Thoru , Shinozaki Gen 
Published: October 2019

ABSTRACTBackground/ObjectivesWe aim to confirm the association between the high risk score on bispectral electroencephalogram (BSEEG) and mortality by comparing outcomes for those with “diffuse slowing” and normal findings on standard EEG.DesignThis is a retrospective study conducted with patient chart data from March 2015 to March 2017.SettingSingle center study at a tertiary care academic hospital in the Midwest region of the USA.Participants1069 subjects aged 55 years and older who were on an inpatient floor or intensive care unit and received a standard 24-hour EEG.MeasurementsPrimary outcome was all-cause mortality at 30-, 90-, 180-, and 365-days. Secondary outcomes were time-to-discharge, and discharge to home.ResultsPatients with “diffuse slowing” on standard EEG was significantly associated with 30-, 90-, 180-, and 365-day mortality (P < .001) compared to those with normal EEG findings when controlling for age, sex, and Carlson Comorbidity Index. Those with diffuse slowing also had a longer time to discharge (P < 0.001) and were less likely to discharge to home (P < 0.001) when controlling for the same factors. Findings were similar when limiting the study to only patients whose clinical status indicated “awake” at time of EEG, except for 30-day mortality.ConclusionOur findings show that a standard EEG finding of “diffuse slowing” for inpatients 55 year or older is associated with greater mortality. This study strengthens the importance of the association found between high BSEEG score and mortality.
Micro-costing Diagnostics in Oncology: From Single-Gene Testing to Whole Genome Sequencing
Authors: Pasmans Clémence TB , Tops Bastiaan BJ , Steeghs Elisabeth MP , Coupé Veerle MH , Grünberg Katrien , de Jong Eiko K , Schuuring Ed MD , Willems Stefan M , Ligtenberg Marjolijn JL , Retèl Valesca P. , van Snellenberg Hans , de Bruijn Ewart , Cuppen Edwin , Frederix Geert WJ 
Published: October 2019

AbstractPurposePredictive diagnostics play an increasingly important role in personalized medicine for cancer treatment. Whole genome sequencing (WGS) based treatment selection is expected to rapidly increase worldwide. Detailed and comparative cost analyses of diagnostic techniques are an essential element in decision-making. This study aimed to calculate and compare the total cost of currently used diagnostic techniques and of WGS in treatment of non-small cell lung carcinoma (NSCLC), melanoma, colorectal cancer (CRC) and gastrointestinal stromal tumor (GIST) in the Netherlands.MethodsThe activity-based costing (ABC) method was conducted to calculate the total cost of included diagnostic techniques based on data provided by Dutch pathology laboratories and the Dutch centralized cancer WGS facility. Costs were allocated to four categories: capital costs, maintenance costs, software costs and operational costs. Outcome measures were total cost per cancer patient per included technique, and the total cost per cancer patient per most commonly applied technique (combination) for each cancer type.ResultsThe total cost per cancer patient per technique varied from € 58 (Sanger sequencing, 3 amplicons) to € 4738 (paired tumor-normal WGS). The operational costs accounted for the vast majority over 90 % of the total per cancer patient technique costs. The most important operational cost drivers were consumables followed by personnel (for sample preparation and primary data analysis).ConclusionThis study outlined in detail all costing aspects and cost prices of current and new diagnostic modalities used in treatment of NSCLC, melanoma, CRC and GIST in the Netherlands. Detailed cost differences and value comparisons between these diagnostic techniques enable future economic evaluations to support decision-making on implementation of WGS and other diagnostic modalities in routine clinical practice.
Yolk-Sac-Derived Macrophages Progressively Expand in the Mouse Kidney with Age
Authors: Ide Shintaro , Yahara Yasuhito , Kobayashi Yoshihiko , Strausser Sarah A. , Watwe Anisha , Pivratsky Jamie R. , Crowley Steven D. , Shinohara Mari L. , Alman Benjamin A. , Souma Tomokazu 
Published: October 2019

AbstractRenal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and hematopoietic stem cells (HSC). They promote both injury and repair by regulating inflammation, angiogenesis, and tissue remodeling. Recent reports highlight differential roles for ontogenically distinct renal macrophage populations in disease. However, little is known about how these populations change over time in normal, uninjured kidneys. Prior reports demonstrated a high proportion of HSC-derived macrophages in the young adult kidney. Unexpectedly, using genetic fate-mapping and parabiosis studies, we find that yolk-sac-derived macrophages progressively expand in number with age and become a major contributor to the renal macrophage population in older mice. This chronological shift in macrophage composition involves cellular proliferation and recruitment from circulating progenitors and may contribute to the distinct immune responses, limited reparative capacity, and increased disease susceptibility of kidneys in the elderly population.