bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes
Authors: Liu Wangshu , Tang Mengjie , Xu Tianli , Su Jianbin , Wang Xue-Qin , Xu Feng , Zhang Dongmei , Zhu Qing , Cao Jie , Wang Hong 
Published: May 2020

Abstract
Background The role of serum fibroblast growth factor 19 (FGF19) in the arteriosclerosis is not well known. In the present study, we aimed to explore whether serum FGF19 levels were related to the arteriosclerosis parameters, including arterial stiffness and atherogenic index of plasma (AIP), in patients with type 2 diabetes (T2D). Methods 200 patients with type 2 diabetes and 50 healthy controls were recruited for this study from Apr 2017 to Oct 2018. Serum FGF19 levels, arterial stiffness assessed by brachial ankle pulse wave velocity (baPWV), and AIP assessed by ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) were measured in those subjects. In addition, other relevant clinical data were also collected. Results Serum FGF19 levels in T2D patients were significantly lower than that in healthy controls ( p < 0.01). The arteriosclerosis parameters, including baPWV and AIP, significantly decreased across ascending tertiles of serum FGF19 levels (all p for trend < 0.001). Moreover, the baPWV and AIP were all inversely correlated with serum FGF19 levels ( r = –0.351 and –0.303, respectively, p < 0.001). Furthermore, after adjusting for other clinical covariates by multiple linear regression analyses, the serum FGF19 levels were independently associated with baPWV ( β = –0.20, t = –2.23, p = 0.029) and AIP ( β = –0.28, t = –2.66, p = 0.010) in patients with T2D. Conclusions The serum FGF19 levels were independently and inversely associated with baPWV and AIP in patients with T2D, which indicate serum FGF19 may plays a protect role against pathogenesis of the atherosclerosis in those patients.
Explaining the variation in the attained power of a stepped-wedge trial with unequal cluster sizes
Authors: Ouyang Yongdong , Karim Mohammad Ehsanul , Gustafson Paul , Field Thalia S. , Wong Hubert 
Published: May 2020

Abstract
Background In a cross-sectional stepped-wedge trial with unequal cluster sizes, attained power in the trial depends on the realized allocation of the clusters. This attained power may differ from the expected power calculated using standard formulae by averaging the attained powers over all allocations the randomization algorithm can generate. We investigated the effect of design factors and allocation characteristics on attained power and developed models to predict attained power based on allocation characteristics. Method Based on data simulated and analyzed using linear mixed-effects models, we evaluated the distribution of attained powers under different scenarios with varying intraclass correlation coefficient (ICC) of the responses, coefficient of variation (CV) of the cluster sizes, number of cluster-size groups, distributions of group sizes, and number of clusters. We explored the relationship between attained power and two allocation characteristics: the individual-level correlation between treatment status and time period, and the absolute treatment group imbalance. When computational time was excessive due to a scenario having a large number of possible allocations, we developed regression models to predict attained power using the treatment-vs-time period correlation and absolute treatment group imbalance as predictors. Results The risk of attained power falling more than 5% below the expected or nominal power decreased as the ICC or number of clusters increased and as the CV decreased. Attained power was strongly affected by the treatment-vs-time period correlation. The absolute treatment group imbalance had much less impact on attained power. The attained power for any allocation was predicted accurately using a logistic regression model with the treatment-vs-time period correlation and the absolute treatment group imbalance as predictors. Conclusion In a stepped-wedge trial with unequal cluster sizes, the risk that randomization yields an allocation with inadequate attained power depends on the ICC, the CV of the cluster sizes, and number of clusters. To reduce the computational burden of simulating attained power for allocations, the attained power can be predicted via regression modeling. Trial designers can reduce the risk of low attained power by restricting the randomization algorithm to avoid allocations with large treatment-vs-time period correlations.
Measuring and assessing the competencies of preceptors in health professions: a systematic scoping review.
Authors: Bartlett Andrew , Um Irene S , Luca Edward J , Krass Ines , Schneider Carl R 
Published: May 2020

Abstract
Background: In healthcare, preceptors act as a role model and supervisor, thereby facilitating the socialisation and development of the preceptee into a professional fit to practice. To ensure a consistent approach to every preceptorship experience, preceptor competencies should be measured or assessed to ensure that the desired outcomes are achieved. Defining these would ensure quality management and could inform development of an preceptor competency framework.This review aimed to evaluate the evidence for preceptor competencies and assessment in health professions.Methods: This study followed the PRISMA ScR scoping review guidelines. A database search was conducted in Embase, Medline, CINAHL and IPA in 2019. Articles were included if they defined criteria for competency, measured or assessed competency, or described performance indicators of preceptors. A modified GRADE CERQual approach and CASP quality assessment were used to appraise identified competencies, performance indicators and confidence in evidence. Results: Forty one studies identified 17 evidence-based competencies, of which 11 had an associated performance indicator. The competency of preceptors was most commonly measured using a preceptee completed survey (moderate to high confidence as per CERQual), followed by preceptor self-assessment, and peer-assessment. Preceptee outcomes as a measure of preceptor performance had good but limited evidence. Conclusions: Competencies with defined performance indicators allow for effective measurement and may be modifiable with training. To measure preceptor competency, the preceptor perspective, as well as peer and preceptee assessment is recommended. These findings can provide the basis for a common preceptor competency framework in health professions.
Statistical modeling of number of human deaths per road traffic accident in Oromia region, Ethiopia
Authors: Aga Merga Abdissa , Woldeamanuel Berhanu Teshome , Tadesse Mekonnen 
Published: May 2020

Abstract
Background: Globally, road traffic accidents are leading causes of death among young people in general, and the main cause of death among young people aged 15–29 years. Recently, in Ethiopia, the average number of road traffic accidents has been increasing, particularly the Oromia regional state is experiencing a higher road traffic fatalities. This study was conducted to identify the major factors associated with the number of human deaths by road traffic accident in the Oromia Regional State, Ethiopia. Methods: We used data obtained from the Oromia Police Commission Bureau that have been recorded on daily basis road traffic accidents from July, 2016 - July, 2017. Count regression models were was used to assess the factors associated with the number of human deaths from road traffic accidents.Results: Of the total of 3900 road traffic accidents included in the 1188 (30.5%) were giving rise to fatal. The Hurdle models were of better fit than zero inflated Poisson and zero inflated negative binomial model. Thus, the Hurdle Poisson is recommended in this study. Age of the driver 31-50 years (AOR = 0.289, 95%CI: 0.175, 0.479) and higher than 50 years of age (AOR = 0.311, 95%CI: 0.129, 0.751), driver’s years of experience 5-10 years (AOR = 0.014, 95%CI:0.007, 0.027), and more than 10 years (AOR = 0.101, 95%CI:0.057, 0.176), vehicle type automobile (AOR = 8.642, 95%CI:2.7644, 27.023), vehicle years of service 5-10 years (AOR = 2.484, 95%CI:1.194, 5.169), and more than 10 years (AOR = 2.639,95%CI:1.268, 5.497), type of accident, vehicle upside down (AOR = 5.560,95%CI: 2.506, 12.336), causes of accident, turning illegal position (AOR = 0.454, 95%CI:0.226, 0.913), area of accident, residential place (AOR = 108.506, 95%CI: 13.725, 857.798), working areas (AOR = 129.606, 95%CI: 16.448, 1021.263), near hospitals (AOR =23.789, 95%CI: 3.038, 186.298), geographical locations, Western zones (AOR = 0.275, 95%CI: 0.167, 0.455), and South east zones (AOR = 0.624, 95%CI: 0.410, 0.950) were significant associated number of human deaths per road traffic accident factors in the study area.Conclusion: In this study,30.5% of accidents were giving rise to at least one human death per road traffic accident and different associated numbers of human deaths per road traffic accident factors have been identified. Thus, interventions by the bodies concerned with introduction educational programs that will create awareness about road traffic accidents and the associated human deaths, especially targeting road users, young drivers, passengers and pedestrians.
The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm
Authors: Miyamoto Kazuya , Matsumoto Kazuyuki , Kato Hironari , Yoshida Ryuichi , Umeda Yuzo , Matsumi Akihiro , Saragai Yosuke , Fujii Yuki , Yamazaki Tatsuhiro , Uchida Daisuke , Tomoda Takeshi , Horiguchi Shigeru , Yagi Takahito , Okada Hiroyuki 
Published: May 2020

Abstract
Background
Pancreatic juice cytology (PJC) is a tool for diagnosing malignant intraductal papillary mucinous neoplasm (IPMN); however, the accuracy is insufficient using the conventional method. Liquid-based cytology (LBC) improves the cell recovery rate, and almost all cells can be evaluated. We evaluated the efficacy of PJC with LBC for malignant IPMN.
Methods
We retrospectively analyzed 90 patients with suspected malignant IPMN who underwent PJC before pancreatectomy. PJC with smear and LBC methods was conducted in 52 patients (between June 2003 to December 2011) and 38 patients (between January 2012 to December 2018). Based on the imaging studies, all of the patients were classified according to the international consensus guidelines for IPMN revised in 2017.
Results
Of the 90 patients, 43 (48%) had malignant IPMN (high-grade dysplasia or invasive carcinoma), and the remaining patients had non-malignant IPMN (intermediate- or low-grade dysplasia). LBC increased the accuracy of PJC for the diagnosis of malignant IPMN (smear method: 56% [29/52] vs. LBC method: 76% [29/38]; P = 0.044). In a multivariate analysis, LBC was a significant factor influencing the accurate diagnosis of PJC (odds ratio: 3.52; P = 0.021). Furthermore, LBC increased the accuracy of PJC for malignant IPMN in patients with worrisome features (smear method: 66% [19/29] vs. LBC method: 93% [14/15]; P = 0.043).
Conclusions
LBC increases the accuracy of PJC for diagnosing malignant IPMN compared with the conventional smear method.
Complications to 6 months following total hip or knee arthroplasty: Observations from an Australian clinical outcomes registry
Authors: Heo Sung Mu , Harris Ian , Naylor Justine , Lewin Adriane 
Published: May 2020

Abstract
Background
Total hip and total knee arthroplasty (THA/TKA) are increasing in incidence annually. While these procedures are effective in improving pain and function, there is a risk of complications.
Methods
Using data from an arthroplasty registry, we described complication rates including reasons for reoperation and readmission from the acute period to six months following THA and TKA in an Australian context. We also used logistic regression to identify risk factors for complications.
Results
In the 8,444 procedures included for analysis, 39.7% of THA and 53.6% of TKA patients reported a major or minor complication. In THA patients, factors associated with increased risk for complications included increased BMI, previous THA and bilateral surgery, whereas in TKA patient factors were heart disease, neurological disease, and pre-operative back pain and arthritis in a separate joint. Female gender and previous TKA were identified as protective factors for minor complications in TKA patients.
Conclusion
We found moderate rates of major and high rates of minor postoperative complications following THA and TKA in Australia and have identified several patient factors associated with these complications. Efforts should be focused on identifying patients with higher risk and optimising pre- and post-operative care to reduce the rates of these complications.
Endoscopic Endoclip Papilloplasty Preserves Sphincter of Oddi Function After Endoscopic Sphincterotomy in Porcine Models
Authors: Wang YingChun , Chang Hong , Zhang YaoPeng , Wang Kun , Zhang HeJun , Yan XiuE , Meng LingYu , Yao Wei , Li Ke , Huang YongHui 
Published: May 2020

Abstract
Background

Endoscopic sphincterotomy (EST) can destroy sphincter of Oddi (SO) function and plays a role in recurrent choledocholithiasis and cholangitis development. The purpose of this study was to assess the feasibility of endoscopic endoclip papilloplasty (EEPP) in restoring SO function after EST.
Methods

Seven 26-week-old domestic pigs were divided into control and EEPP groups. Necropsy, hematoxylin-eosin staining, anti-α-smooth muscle actin (α-SMA) staining of papilla and sphincter of Oddi manometry (SOM) were conducted in animals at three independent time points.
Results

EST and EEPP were safely performed in all 7 pigs without serious adverse events. For primary outcome, compared to the controls, EEPP generated smaller dilation with less inflammation. Fibrous repair of the papilla was observed at 24 weeks after EEPP. For secondary outcome, in the control group, SO basal pressure (17.25 ± 18.14 to 5.50 ± 0.71 mmHg), SO contraction amplitude (46.00 ± 19.20 to 34.50 ± 48.79 mmHg), peak (4.50 ± 4.04 to 1.50 ± 2.12) and frequency (3.05 ± 3.29 to 1.41 ± 2.19 /min) reduced after EST. Further reductions to almost 0 were observed 3 weeks later, including common bile duct pressure and SO contraction period. In contrast, in the EEPP group, these manometric data recovered to pre-EST levels, such as CBD pressure (11.5 ± 7.31 vs 11 ± 2.16 mmHg), SO pressure (17.50 ± 17.75 vs 18.20 ± 21.39 mmHg) and SO contraction amplitude (53.67 ± 21.54 vs 60.00 ± 36.08 mmHg). However, no significant differences were observed by Student t-test.
Conclusions

In this porcine study, EEPP had accelerated and improved papillary healing after EST, and preserved SO function.
Dysbiosis of Gut Microbiota with Increased Trimethylamine N-oxide Level in Patients with Large Artery Atherosclerotic and Cardioembolic Strokes
Authors: Xu Dong-Juan , Wang Kaicheng , Yuan Lin-Bo , Lin Qiong-Qiong , Li Hong-Fei , Xu Yun-Yun , Wei Lian-Yan , Chen Li , Jin Ke-Ke 
Published: May 2020

Abstract
Background — With the establishment of the concept of the gut–brain axis, increasing evidence has shown that the gut microbiome plays an important role in the pathogenesis of cardiovascular diseases. Gut bacteria can transform dietary choline, L-carnitine, and trimethylamine N-oxide (TMAO) into trimethylamine, which can be oxidized into TMAO again in the liver and participate in atherogenesis. However, only few studies have described alterations in the gut microbiota composition and function in cardioembolic (CE) and large artery atherosclerotic (LAA) strokes.Methods and Results — A case–control study was performed on patients with LAA and CE strokes. TMAO was determined via liquid chromatography tandem mass spectrometry. Gut microbiome was profiled through Illumina sequencing of the 16S ribosomal RNA gene (V4–V5 regions). The TMAO levels in the plasma of patients with LAA and CE strokes were significantly increased (TMAO: LAA stroke, 2931±456.4 ng/mL vs. CE stroke, 4220±577.6 ng/mL vs. control, 1663±117.8 ng/mL; P < 0.05). The TMAO level in patients with LAA stroke was positively correlated with the carotid plaque area (rho = 0.333, 95% confidence interval = 0.08 to 0.55, and P = 0.0093). The composition and function of gut microbiomes in the LAA and CE stroke groups were significantly different from those of the asymptomatic control. In addition to the significantly increased α and β diversities, the gut microbiome composition and function showed that the LAA group had more microorganisms than the asymptomatic control group; such microorganisms convert dietary source choline, TMAO to TMA. Parabacteroides and Streptococcus exhibited the strongest association with LAA and CE strokes.Conclusions — This study established the compositional and functional alterations of gut microbiomes in patients with LAA and CE strokes and the relationship between plasma TMAO and gut microbiota. The findings suggest the potential of using gut microbiota as a biomarker for patients with LAA and CE strokes.
Albumin-bound paclitaxel and gemcitabine combination therapy in soft tissue sarcoma
Authors: Tian Zhichao , Zhang Fan , Li Po , Wang Jiaqiang , Yang Jinpo , Zhang Peng , Yao Weitao , Wang Xin 
Published: May 2020

Abstract
Background: The evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. However, the clinical data and evidence of nab-paclitaxel and gemcitabine in metastatic soft tissue sarcoma (STS) treatment are rare.Methods: The data of 17 patients with metastatic STS who received nab-paclitaxel/ gemcitabine chemotherapy between January 2019 and February 2020 were retrospectively reviewed. All patients were treated with nab-paclitaxel/ gemcitabine only after doxorubicin-based chemotherapy had failed. We evaluated the median progression-free survival (m-PFS), disease control rate (DCR), objective response rate (ORR) and adverse events (AEs) in these patients.Results: The m-PFS was 6 months (95% CI, 2–9 months), ORR was 41.2% and DCR was 70.6%. The average change in target lesion diameter from baseline was -19.06±45.74%. While the majority of the treatment patients experienced grade 1 or 2 AEs, grade 3 or 4 AEs were not common, but included neutropenia (17.6%), fatigue (11.8%), anemia (11.8%), leukopenia (11.8%), nausea (5.9%), peripheral neuropathy (5.9%), diarrhea (5.9%), and thrombocytopenia (5.9%). No treatment-related deaths occurred. Conclusion: Nab-paclitaxel/ gemcitabine combination chemotherapy is comparatively effective in the treatment of STS, demonstrates low toxicity, and is worthy of further study.
Transcriptomic analysis of a-linolenic acid content and biosynthesis in Paeonia ostii fruits and seeds
Authors: Hu Yonghong , Yu Shui-Yan , Zhang Xiao , Huang Liang-Bo , Lyu Yu-Ping , Zhang Ying , Yao Zu-Jie , Zhang Xiao-Xiao , Yuan Jun-Hui 
Published: May 2020

Abstract
Background
Paeonia ostii is a potentially important oilseed crop because its seed yield is high and the seeds are rich in α-linolenic acid (ALA). However, the molecular mechanisms underlying ALA biosynthesis during seed kernel, seed testa, and fruit pericarp development in this plant are unclear. We used transcriptome data to address this knowledge gap.
Results
Gas chromatograph-mass spectrometry indicated that ALA content was highest in the kernel, moderate in the testa, and lowest in the pericarp. Therefore, we used RNA-sequencing to compare ALA synthesis among these three tissues. We identified 227,837 unigenes, with an average length of 755 bp. Of these, 1371 unigenes were associated with lipid metabolism. The fatty acid (FA) biosynthesis and metabolism pathways were significantly enriched during the early stages of oil accumulation in the kernel. ALA biosynthesis was significantly enriched in parallel with increasing ALA content in the testa, but these metabolic pathways were not significantly enriched during pericarp development. By comparing unigene transcription profiles with patterns of ALA accumulation, specific unigenes encoding crucial enzymes and transcription factors (TFs) involved in de novo FA biosynthesis and oil accumulation were identified. Specifically, the bell-shaped expression patterns of genes encoding SAD, FAD2, FAD3, PDCT, PDAT, OLE, CLE, and SLE in the kernel were similar to the patterns of ALA accumulation in this tissue. Genes encoding BCCP, BC, KAS I– III, and FATA were also upregulated during the early stages of oil accumulation in the kernel. In the testa, the upregulation of the genes encoding SAD, FAD2, and FAD3 was followed by a sharp increase in the concentrations of ALA. In contrast, these genes were minimally expressed (and ALA content was low) throughout pericarp development.
Conclusions
In this study, we used three tissues with high, moderate, and low ALA concentrations as an exemplar system in which to compare tissue-specific ALA accumulation mechanism in P. ostii. The genes and TFs identified herein might be useful targets for future studies of ALA accumulation in the tree peony. This study also provides a framework for future studies of FA biosynthesis in other oilseed plants.
Transcriptome analysis of two contrasting genotypes of pearl millet to gain insight into heat stress responses
Authors: Maibam Albert , Nigombam Sunil , Vishwakarma Harinder , Lone Showkat Ahmad , Gaikwad Kishor , Mithra S. V. Amitha , Singh Madan Pal , Singh Sumer Pal , Dalal Monika , Padaria Jasdeep Chatrath 
Published: May 2020

Abstract
The authors have withdrawn this preprint due to erroneous posting.
Difference Analysis of the Contribution of E-commerce and Modern Logistics to Regional Economy Based on Wireless Network
Authors: Tang Xiaodong , Wang Gangyi 
Published: May 2020

Abstract
The rapid development of e-commerce has greatly promoted the development of the modern logistics industry. The application level of e-commerce and the application status of modern logistics largely determine the development of regional economic structure in a region. Under this circumstance, it is particularly important to comprehensively strengthen the research and analysis of the impact of e-commerce and modern logistics on the regional economic structure and scope, and promote the coordinated development between each other. As one of the most developed regions in China, the Yangtze River Delta region has achieved certain achievements in the development of regional logistics industry and e-commerce, and plays an important role in the process of regional integration in the Yangtze River Delta. Therefore, this paper takes the Yangtze River Delta as the research object, and empirically analyses the development status of the logistics industry and e-commerce in the Yangtze River Delta region and its contribution to regional economic growth. On this basis, it puts forward countermeasures to further increase the contribution of the logistics industry and e-commerce in the Yangtze River Delta region to economic growth. This will provide a reference for the construction of a coordinated regional logistics-e-commerce system and the realization of regional economic integration in the Yangtze River Delta region.