bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative evaluation of dexmedetomidine and ketamine for epidural analgesia in lower limb orthopedic surgeries
Authors: Shah Ayush , J Pandya Malti 
Published: February 2020

The combined spinal epidural anesthesia (CSE) plays a unique role in management of perioperative analgesia. It is associated with early postoperative mobilization and rehabilitation with minimally associated pain and discomfort, which is the most desirable feature in modern surgery.We designed this study for comparative evaluation of dexmedetomidine and ketamine for epidural analgesia in lower limb orthopedic surgeries in patients operated under CSE. The study included 50 patients divided into two groups (25 each). Group D: Patient received bolus dose of dexmedetomidine 1 µg/kg after spinal anesthesia followed by bupivacaine 0.125% with dexmedetomidine 1 µg/ml epidurally using 240 ml elastomeric pump at 5ml/ hr till 48 hours. Group K: Patient received bolus dose of ketamine 0.5 mg/kg after spinal anesthesia followed bupivacaine 0.125% with ketamine 0.5mg/ml epidurally using elastomeric pump at 5ml/hr till 48 hours. There was no significant difference between the two groups (p&#62;0.05) in terms of highest sensory level achieved and time for complete motor block. The patients in both the groups were hemodynamicaly stable throughout the study. The duration of analgesia was longer with dexmedetomidine however, none of the patients in both the groups required rescue analgesic. The time to regression of sensory level to L5 in Group D was found to be 594 ± 63.04 minutes as compared to 362.4 ± 45.76 minutes in Group K (p &#60; 0.001) while, the time to regression of motor block to Bromage scale 1 in Group D was 488.4 ± 42.88 minutes whereas, in Group K it was 303.6 ± 36.04 minutes (p &#60; 0.001). The incidence of sedation, nausea, vomiting and other side effects were comparable. We conclude that continuous epidural infusion with dexmedetomidine and ketamine effectively reduced the postoperative rescue analgesics requirements and provided good patient satisfaction in patients undergoing lower limb orthopedic surgery.
Sedative effect of propofol and midazolam in surgery under spinal anaesthesia: A comparative study
Authors: F Maliwad Jyotsna , N Patel Jalpen , J Mehta Purvi , D Damor Raman , S Shringarpure Kalpita 
Published: February 2020

Intravenous medications are invariably required to allay anxiety related to surgical procedures, in patients undergoing surgery under regional anesthesia. A thorough pre anaesthetic check up and details of the surgical procedure planned are necessary before administration of sedative agents to attain desirable levels of sedation and avoid unwanted adverse events. To observe, record and analyse sedative effect of intravenous Propofol and Midazolam in lower extremities and lower abdominal surgery scheduled under regional anesthesia techniques.: A single blinded comparative study conducted in tertiary care hospital of Gujarat. Sixty patients with no organic pathology & a moderate but definite systemic disturbance categorized into two groups labeled as propofol group (n=30) and Midazolam group (n=30) of either gender and shortlisted for surgery using subarachnoid block. Observer’s Assessment of Alertness/Sedation Scale (OAA/S Scale) and Ramsay sedation scale was used to assess effective sedation.: Basic patients characteristics, Mean age (SD) was 31.57 + 10.57 years in category I (P group) and 35.33 + 9.98 years in category II (M group) was comparable between the groups. In category I 16(53.3%) patients reached targeted sedation level in &#60; 60 seconds, in group M 18 (60%) patients required 90-120 seconds to achieved the same level of sedation (p&#60;0.001). Propofol gives rapid onset of sedation and faster recovery, while midazolam provides more hemodynamic stability in regional anesthesia.
Comparison of the etiological causes in patients under and/or over the age of 65 admitted to the emergency department with non-traumatic chest pain
Authors: YILMAZ Funda , ARMAĞAN Erol , KAYA Halil , YÜKSEL Melih , ÇELİK Kamuran , UYGUN Erman , ÖZKAN YILDIZ Havva Özge , GAFUROĞULLARI Sibel 
Published: February 2020

Objectives: One of the most common reasons for admission to the emergency department is chest pain. The clinical presentation of chest pain is quite wide. The study aimed to compare the diagnoses of patients under and/or over the age of 65 admitted to the emergency department with non-traumatic chest pain.Methods: A thousand patients admitted to the emergency department with non-traumatic chest pain between 15.10.2014 and 15.07. 2015 were included in the study. Patients were divided into two groups according to age group as &lt; 65 years old and ≥ 65 years old. Age, gender, the type of admission, comorbidities, accompanying symptoms, diagnosis, outcome and hospitalization were recorded.Results: Five hundred eighteen males and 482 females were included in the study. Eight hundred nineteen patients were between the ages of 18 to 64. The most common accompanying symptom was dyspnea in both age groups. Hypertension was the most common concomitant disease in the 18-64 year age group while coronary artery disease was the most common diseasein the 65 and over age group. Conclusions: Non-cardiac chest pain is more common in the young population admitted to the emergency department while life-threatening chest pain is more common in the population over the age of 65.
An approach to diagnosing brain death in patients undergoing extracorporeal membrane oxygenation
Authors: ALTINSOY Savaş , BARAN AKKUŞ İlkay , ÇATALCA Sibel , KAVAK AKELMA Fatma , ÖZHAN ÇAPARLAR Ceyda , ERGİL Jülide 
Published: February 2020

Objectives: This study was intended to discuss the process of brain death diagnosis of patients undergoing extracorporeal membrane oxygenation (ECMO) and our approach regarding the existing literature. Methods: Demographics data (age, gender, admission diagnosis) were noted. ECMO type applied (veno-venous or veno-arterial), time of diagnosing brain death (the time from admission time till diagnosis), being a donor or not, apnea testing application, supplementary tests applied at diagnosis stage (cerebral angiography, computerized tomography angiography, electroencephalography, transcranial doppler ultrasonography), and time of cardiac death (the time elapsing from the moment of brain death diagnosis till cardiac arrest) were noted. Results: Forty-two patients data were exaimed and ECMO was applied to 8 patients, 4 of whom are female and the others are male. The average age of the patients is 61.8 ± 9.8 years. The average time elapsing from the hospitalization till brain death diagnosis was 2.5 ± 0.5 days. Apart from that, only 2 (25%) of the patients were donors.Conclusions: The use of modified apnea testing on patients undergoing ECMO could be proliferated if such tests are standardized and reliable guidelines are set. For this reason, we think that cerebral angiography should be kept in mind in addition to apnea test especially on ECMO-treated patients.
Implementasi Kurikulum 2013 oleh Guru Pendidikan Agama Islam pada Sekolah Dasar di Samarinda
Authors: Jumali Jumali 
Published: February 2020

This study aims to determine how the implementation of the 2013 curriculum by Islamic religious education teachers in elementary schools (SD) in Samarinda. This research is qualitative research and the point of research is in the second semester of Elementary School (SD) in Samarinda City academic year 2013/2014. The data sources used are the Islamic religious teachers in elementary school in Samarinda. The sampling technique used was purposive sampling and snowball sampling. Data collection techniques used is observation, interviews, and documentation. Testing the validity of the data include a test of credibility, transferability, dependability, and conformability. Data analysis techniques used is data reduction, data presentation, and verification.The result of the study shows that the implementation of the 2013 curriculum by Islamic religious teachers in elementary schools in Samarinda, Some of them is still not implementing the standardized processes optimally. Particularly, in the form of teaching planning administration. The problem is the lack of training 2013 curriculum, the lack of technology mastery, too much students, evaluation, and describing value for report cards, lack of cooperation between parents and teachers, the limitations of PAI books in 2013 curriculum.The results of this study concluded that the implementation of the 2013 curriculum by Islamic religious teachers in elementary schools (SD) in Samarinda is not done well and there are too much less optimal in practice.
Implementasi Kurikulum Jaringan Sekolah Islam Terpadu di Sekolah Menengah Pertama Islam Terpadu
Authors: Robingatin Siti 
Published: February 2020

Islamic School Network Integrated Curriculum (JSIT) is a curriculum that integrate curriculum with the curriculum of the National Local Content that based on Islamic education, which includes the National curriculum, the curriculum of Islamic education, Scouting curriculum, and skilled curriculum. Purpose of this study is describing the implementation of the curriculum of Islamic Schools Network Integrated (JSIT) in Junior High School Islam Daarussalaam North Sangatta East Kutai realized in school programs and find the factors supporting and hindering the implementation of the curriculum of Islamic Schools Network Integrated Integrated Islamic (JSIT) in Islamic Integrated Junior High School Daarussalaam North Sangatta East Kutai. Research design of this study is a qualitative research. The main data sources obtained through interviews, observation, and documentation. And data analysis technique obtained from data reduction, data presentation and verification of data by performing triagulasi data. The results of this study that the implementation of the curriculum of Islamic Schools Integrated Network Islamic in Integrated Junior High School (SMPIT) Daarussalaam North Sangatta East Kutai showed the indications on the Internalization of Islamic values in all subjects, local content and program curriculum. Some factors Supported implementation of curriculum Islamic Integrated School Network ISAM (JSIT) are the role of parents both morally and materially. National Education affair minister monitored and evaluated as well as the social environment that religious and strategic place while inhibiting factor Human Resources who lack an understanding of the Integrated Islami Curriculum School (JSIT) and inadequate infrastructure.
Nilai-Nilai Pendidikan Multikultural dalam Al Qur’an: Kajian terhadap Tafsir Al-Azhar Karya Buya HAMKA
Authors: Firman Firman 
Published: February 2020

Quran is life guidance and there is no doubt about it, it is also as a guidance of all human life problems in this world, including problems of multicultural conflicts which occur in the society. Quran which consists of 30 juz 114 surah has explored humanistic principles and values in the interaction to other humans both of in group and inter group interaction need to be studied in order to solve all problems occurs in the society. Problems of this research are: (1) How are main themes of multicultural education values in tafsir Al-Azhar by Buya Hamka? (2) How is the perspective of Buya Hamka towards multicultural education values in tafsir Al-Azhar. This is a library research. Data collection technique is by using documents, the researcher collected and reviewed books, kitab, journals, and other writing materials which are connected to multicultural education and came up with the description. Data of this research was analyzed by using linguistics, sociological, and theological approach. Buya Hamka in interpreting verses about multicultural emphasizes on the concept of unity and similarity. According to Hamka, diversity is a starting points of the conflicts in the life of society. Unity and similarity concept by Buya Hamka can be viewed from two points. They are: (1) Unity and similarity of human origins from the same father and mother. (2) Unity and similarity of aqidah to make human becomes brothers and sisters.
Manajemen Kelembagaan dan Akademik Lembaga Pendidikan Maarif Nahdlatul Ulama Kota Samarinda Kalimantan Timur
Authors: AR Abdurrahman 
Published: February 2020

TheEducational Management and Academic Of Ma’arif Nahdlatul Ulama in Samarinda, East Kalimantan, is to coming up a moeslem organization in the educational prospective and progressive mutual organization and education to come up image of Nahdlatul Ulama as the biggest moeslem organization in Indonesia.The objective of this research was to identificate the Educational management and Academic quality and to doctrine the religious values to the basic Ma’arif Nahdlatul UlamaInstitute in Samarinda, East Kalimantan. This research also designed to get the object datas from the three Islamic Elementry schools which organized by Ma’arif Nahdlatul Ulama Samarinda through many kind ways they are; (1) Interviews Elementry head masters and their commitees, (2) pictures, (3) school’s data or documents.The purpose of data collection wants to understand the Moslem Elementry School of Ma’arif Nahdlatul Ulama conditions in the some areas in Samarinda in order to know what are the weakness and lack of Ma’arif NU. The result of dataanalysis indicated three of Moslem Elementry School Ma’arif NU thoselocated in Samarinda city, they are MI 01 in Palaran, MI.02 Sindang Sari, MI 03 Jln. Rukun Samarinda Seberang, they still run in slowly.The researcher’s summary in this research those, from three of Madrasah Ibtidaiyyah of Educational Institute Ma’arif NU still need high supports from everyone, from moeslem who love education progressive now and the future.
Relationship of Internet gaming disorder with psychopathology and social adaptation in Italian young adults
Authors: de pasquale concetta , Sciacca Federica , Dinaro Carmela , Hichy Zira 
Published: February 2020

Abstract
Background: When the Internet becomes the only interest in an individual's life and everything else is emptied of importance, the isolation in which the subject closes again produces consequences not only from a psychological but also physical and social point of view. The purpose of this study was: a) to investigate the prevalence of internet gaming disorder (IGD) among Italian young adults, b) to explore the associations between the former and psychopathological symptoms, and c) to explore its consequences in social functioning. Methods: The sample included 566 young adults, 324 males and 242 females, aged between 18 and 35 years (M = 22.74; SD = 4.83). They were asked to state their favourite games choice and were administered a demographic questionnaire, the APA symptom checklist based on the diagnostic criteria of IGD in the DSM-5, the Internet Gaming Disorder Scale Short Form (IGD9-SF), the Symptom Checklist-90 Revised (SCL-90 R) and the Social Adaptation Self Evaluation Scale (SASS). Results: The different game types used are distributed as follows: MMORPG (35.7%), flash games (20.3%), multiplayer games (27%), online gambling (9.9%), other games (6.5% ). The results of the study showed high use of videogames (95% of the sample), but low incidence of Internet Gaming Disorder in young adults. Thirty subjects (20 male and 10 female) on 566 (5.3% of the sample) matched five or more criteria for clinical diagnosis of IGD. The data showed a positive correlation between use of online games (total score IGD9-SF), the higher the levels of depression (r = .501), anxiety (r = .361) and psychoticism (r = .431) and the lower the family and extra-family relationships (r = -.383). The linear regression analysis showed that somatization (p = .002), depression (p = .000) and sleep disturbances (p = .003) are predictive variables of internet gaming disorder. Conclusions: This study highlights the need to make a diagnosis of "online gaming addiction" as "independent disorder" to be included in future categorizations according to DSM-5, compared to other addictive behaviors.
Isatin inhibits LSD1 regulated autophagy through SESN2-mTOR signaling pathway in neuroblastoma
Authors: Li Xue , Zhang Li , Nai Yiming , Wang Fangling , Hua Yanan , Zhou Na , Wang Jun , Zheng Wenxiang , Hou Lin 
Published: February 2020

Abstract
Neuroblastoma (NB) is common in the pediatric tumors with low cure rate and high mortality, drug resistance makes chemotherapy more difficult, it threaten to children's health seriously. 1H-indole-2, 3-dione (isatin) is a second-hand of derivative of anticarcinogen indirubin which had been shown to be a monoamine oxidase inhibitor and have antitumor activity, in this study, we explained that SH-SY5Y cells was add to isatin at a dose-dependent level ranging from 50 to 200 µmol/L were capable of inhibiting tumor cell growth, included triggering apoptosis and inhibiting proliferation, invasion and metastasis, and assess ed the potential anticancer capability of isatin on the induction of autophagy. The experimental result showed that cell SH-SY5Y disposed with isatin could induce autophagy effectively, at the same time, it also help suppress the growth of tumor cells. Furthermore , the article indicated that the induction of autophagy of isatin-mediated occurred in inhibition- lysine-specific demethylase 1(LSD1) and sestrin2 (SESN2) - dependent manner. Furthermore, we identified that SH-SY5Y cells after treating with isatin induced SESN2 expression via a mTOR-dependent signal pathway, which mechanism is that isatin inhibit LSD1-enzyme activation and combine the promoter regions of SESN2, so that given rise to a significant transcriptional induction of SESN2. In addition , western blot analysis indicated that SH-SY5Y cells with isatin-exposed can regulated activity of LC-3, Beclin1 and p62 which are correlated with autophagy. Collectively, all the results from this study illistrated that adding to isatin could occur to induce autophagy and restrain NB cell SH-SY5Y growth through mTOR-dependent transcriptional induction of SESN2, this supplied a new mechanism for understanding the anti-tumor ability of isatin on NB. Taken together, this paper demonstrate that isatin is a promising candidate for treating NB.
Evaluation of residual effects of deltamethrin wg250 on different surfaces against An.stephensi, in a malarious area, southern Iran
Authors: Vatandoost Hassan , Abai Mohammad Reza , Dorzadeh Hossein , Shayeghi Mansoreh , Hanafi-bojd Ahmad Ali , Raeisi Ahmad 
Published: February 2020

Abstract
Objective: Malaria is one of the public health problem in southern Iran. The main activity of vector control is indoor residual spraying using pyrethrpids. The aims of study was to evaluate the biological assays of deltamethrin WG250 at different surfaces of wall.Materials and methods: The persistency of deltamethrin WG250 at 25 mg/m2 was studied on different local surfaces of rooms such as plaster and mud surfaces (sorbent) as well as wooden and thatch roofs (as non-sorbent). Contact bioassays were carried out using WHO standard cones and lab-bred sugar-fed, 48-72 h old females of Anopheles stephensi (Iranshahr strain). In contact bioassays carried out on sprayed surfaces for 150 days, Results and discussion: deltamethrin WG250 (25 mg/m2) caused 43.43-100.0% on sorbent surfaces and 61.11-100.0% on non-sorbent surfaces and persist about 3.5 months in the environmental condition of Saravan district. The fumigant bioassay of deltamethrin WG250 revealed 50-100% mortalities after one month.
Complement C3 as therapeutic target in diabetic nephropathy by bioinformatics analysis
Authors: Tang ShuMei , Wang XiuFen , Deng TianCi , Ge HuiPeng , Xiao XiangCheng 
Published: February 2020

Abstract
Background: Various public platforms have contained extensive data for deeper bioinformatics analysis. The pathogenesis of diabetic nephropathy is always a hot topic and the underlying molecular events are not completely clear. Methods: Differential expression analysis and weighted correlation network analysis (WGCNA) were applied to screen meaningful gene in GSE30529. The combined result was used for gene ontology (GO) annotation and KEGG pathway enrichment analysis. STRING was used for protein-protein interaction (PPI) network construction and Cytoscape software was used for hub gene identification. Gene methylation profile GSE121820 and miRNA profile GSE51674 were also acquired to perform multi-omics analysis. Clinical features were obtained form Nephroseq and potential drugs were identified by CMap. Results: 345 genes were obtained form GSE30529 after differential expression analysis and WGCNA. GO analysis mainly included neutrophil activation, regulation of immune effector process, positive regulation of cytokine production and neutrophil mediated immunity. KEGG pathway analysis mostly included phagosome, complement and coagulation cascades, cell adhesion molecules and AGE-RAGE signaling pathway in diabetic complications. 16 down regulated miRNAs were obtained from GSE57674 to construct miRNA-mRNA network. Top 20 genes were discerned from PPI network and there were DNA methylation differences in 15 genes among them. Correlation analysis showed SYK, CXCL1, LYN, VWF, ANXA1, C3, HLA-E, RHOA, SERPING1, EGF and KNG1 may involved in DN. 10 small molecule compounds have been identified as potential therapeutic drugs. Conclusion: We screened 11 target genes and suggested C3 may serve as a therapeutic target in diabetic nephropathy.
Two nuclear localization signals regulate intracellular localization of the Duck enteritis virus UL13 protein
Authors: Yang Linjiang , Hu Xixia , Cheng Anchun , Wang Mingshu , Jia Renyong , Yang Qiao , Wu Ying , Chen Shun , Liu Mafeng , Zhu Dekang , Ou Xumin , Wen Xingjian , Mao Sai , Sun Di , Zhang Shaqiu , Zhao Xinxin , Huang Juan , Gao Qun , Liu Yunya , Yu Yanling , Zhang Ling , TIan Bin , Pan Leichang , Rehman Mujeeb Ur , Chen Xiaoyue 
Published: February 2020

Abstract
Background UL13 multifunctional tegument protein of duck enteritis virus (DEV) is predicted as protein kinase (CHPK); however, little is known concerning its subcellular localization signal. Results In this study, by transfection with two predicted nuclear signals of DEV UL13 fused to enhanced green fluorescent protein (EGFP), two bipartite nuclear localization signal (NLS) was identified. We identified the nuclear localization signals (NLSs) that control its nuclear importing using fluorescence assay and proved that nuclear localization of DEV UL13 is a classical importin α/β-dependent process. And we constructed the mutant DEV, with the NLSs of UL13 deleted, to explore whether it will affect the replication of virus particles. Conclusions DEV UL13 protein is directed by amino acids 4 to 7 and 90 to 96, and proved that this nuclear import occurs via the classical importin α/β-dependent process. And Entry nucleus of UL13 protein has no effect on DEV replication in cell culture. Our study enhances the understanding of DEV pUL13. Taken together, these results would provide significant information for the stud y of the biological function of UL13 during DEV infection.