bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring crossmodal perceptual enhancement and integration in a sequence-reproducing task with cognitive priming
Authors: Feng Feng , Li Puhong , Stockman Tony 
Published: July 2020

AbstractCrossmodal correspondence, a perceptual phenomenon which has been extensively studied in cognitive science, has been shown to play a critical role in people’s information processing performance. However, the evidence has been collected mostly based on strictly-controlled stimuli and displayed in a noise-free environment. In real-world interaction scenarios, background noise may blur crossmodal effects that designers intend to leverage. More seriously, it may induce additional crossmodal effects, which can be mutually exclusive to the intended one, leading to unexpected distractions from the task at hand. In this paper, we report two experiments designed to tackle these problems with cognitive priming techniques. The first experiment examined how to enhance the perception of specific crossmodal stimuli, namely pitch–brightness and pitch–elevation stimuli. The second experiment investigated how people perceive and respond to crossmodal stimuli that were mutually exclusive. Results showed that first, people’s crossmodal perception was affected by cognitive priming, though the effect varies according to the combination of crossmodal stimuli and the types of priming material. Second, when two crossmodal stimuli are mutually exclusive, priming on only the dominant one (Pitch–elevation) lead to improved performance. These results can help inform future design of multisensory systems by presenting details of how to enhance crossmodal information with cognitive priming.
Metabolic Parameters as Predictors for Progression Free and Overall Survival of Patients with Metastatic Colorectal Cancer
Authors: Nemeth Zsuzsanna , Wijker Wouter , Lengyel Zsolt , Hitre Erika , Borbely Katalin 
Published: July 2020

AbstractWe tested the prognostic relevance of metabolic parameters and their relative changes in patients with metastatic colorectal cancer (mCRC) treated with monoclonal antibody and chemotherapy. SUVmax (standardized uptake volume), SAM (standardized added metabolic activity) and TLG (total lesion glycolysis) are assessed with 18F-fluorodeoxyglucosepositron emission tomography and computed tomography (FDG-PET/CT) to evaluate total metabolic activity of malignant processes. Our purpose was to investigate the change of glucose metabolism in relation to PFS (progression free survival) and OS (overall survival). Fifty-three patients with mCRC with at least one measurable liver metastasis were included in this prospective, multi-center, early exploratory study. All patients were treated with first-line chemotherapy and targeted therapy. Metabolic parameters, like SUVmax, SAM, normalized SAM (NSAM) and TLG were assessed by FDG-PET/CT, carried out at baseline (scan-1) and after two therapeutic cycle (scan-2). Our results suggested neither SUVmax nor TLG have such prognostic value as NSAM in liver metastases of colorectal cancer. The parameters after the two cycles of chemotherapy proved to be better predictors of the clinical outcome. NSAM after two cycles of treatment has a statistically significant predictive value on OS, while SAM was predictive to the PFS. The follow up normalized SAM after 2 cycles of first line oncotherapy was demonstrated to be useful as prognostic biomarkers for OS in metastatic colorectal cancer. We should introduce this measurement in metastatic colorectal cancer if there is at least one metastasis in the liver.
Ongoing transcatheter aortic valve implantation (TAVI) practice amidst a global COVID-19 crisis: nurse-led analgesia for transfemoral TAVI
Authors: Vendrik J. , de Boer J. , Zwiers W. , van Gilst S. A. , Holierook M. , Chekanova E. V. , Henriques J. S. , Baan J. 
Published: July 2020

AbstractThe current coronavirus disease 2019 (COVID-19) crisis has led to a relative unavailability of anaesthesiological support for non-acute cardiac care. Currently, transfemoral transcatheter aortic valve implantation (TF-TAVI) is predominantly performed as an elective catheterisation laboratory (cath lab) procedure. Hence, the performance of TAVI could come to a halt amidst the COVID-19 crisis. Our study population comprised 90 patients treated with TF-TAVI, with local analgesia performed by our dedicated cath lab nurses. The patients had a mean age of 80 ± 5 years and 59% were male, with a predicted surgical risk of 2.2 ± 0.9/3.1 ± 2.4% (Society of Thoracic Surgeons Predicted Risk of Mortality [STS-PROM] score/EuroSCORE II), depicting a contemporary, lower-risk population. The composite endpoint of device success (Valve Academic Research Consortium [VARC]-2) was reached in all patients. No patients showed more than mild paravalvular leakage (3/90, 3.3%). Overall, intravenous medication was sparsely used during the procedure, with 48 of the 90 (53%) patients receiving no unplanned intravenous medication. There was neither procedural nor in-hospital mortality. The performance of TF-TAVI using local analgesia only, managed by a dedicated nurse instead of an anaesthesiologist, was shown to be feasible and safe in a selected group of patients. This strategy may (temporarily) eliminate the need for an anaesthesiologist to be present in the cath lab and enables ongoing TAVI treatment amidst the global COVID-19 crisis.
Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland
Authors: Coste A. T. , Kritikos A. , Li J. , Khanna N. , Goldenberger D. , Garzoni C. , Zehnder C. , Boggian K. , Neofytos D. , Riat A. , Bachmann D. , Sanglard D. , Lamoth F. ,   The Fungal Infection Network of Switzerland (FUNGINOS), Lamoth F. , Khanna N. , Boggian K. , Sanglard D. 
Published: July 2020

AbstractEchinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15–77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.
Circadian Rhythms in Environmental Health Sciences
Authors: Leung Jacqueline M. , Martinez Micaela E. 
Published: July 2020

Abstract
Purpose of Review
This review aims to explore how circadian rhythms influence disease susceptibility and potentially modify the effect of environmental exposures. We aimed to identify biomarkers commonly used in environmental health research that have also been the subject of chronobiology studies, in order to review circadian rhythms of relevance to environmental health and determine if time-of-day is an important factor to consider in environmental health studies. Moreover, we discuss opportunities for studying how environmental exposures may interact with circadian rhythms to structure disease pathology and etiology.

Recent Findings
In recent years, the study of circadian rhythms in mammals has flourished. Animal models revealed that all body tissues have circadian rhythms. In humans, circadian rhythms were also shown to exist at multiple levels of organization: molecular, cellular, and physiological processes, including responding to oxidative stress, cell trafficking, and sex hormone production, respectively. Together, these rhythms are an essential component of human physiology and can shape an individual’s susceptibility and response to disease.

Summary
Circadian rhythms are relatively unexplored in environmental health research. However, circadian clocks control many physiological and behavioral processes that impact exposure pathways and disease systems. We believe this review will motivate new studies of (i) the impact of exposures on circadian rhythms, (ii) how circadian rhythms modify the effect of environmental exposures, and (iii) how time-of-day impacts our ability to observe the body’s response to exposure.
Engineering Mesoporous Structure in Amorphous Carbon Boosts Potassium Storage with High Initial Coulombic Efficiency
Authors: Guo Ruiting , Liu Xiong , Wen Bo , Liu Fang , Meng Jiashen , Wu Peijie , Wu Jinsong , Li Qi , Mai Liqiang 
Published: July 2020

AbstractAmorphous carbon shows great potential as an anode material for high-performance potassium-ion batteries; however, its abundant defects or micropores generally capture K ions, thus resulting in high irreversible capacity with low initial Coulombic efficiency (ICE) and limited practical application. Herein, pore engineering via a facile self-etching strategy is applied to achieve mesoporous carbon (meso-C) nanowires with interconnected framework. Abundant and evenly distributed mesopores could provide short K+ pathways for its rapid diffusion. Compared to microporous carbon with highly disordered structure, the meso-C with Zn-catalyzed short-range ordered structure enables more K+ to reversibly intercalate into the graphitic layers. Consequently, the meso-C shows an increased capacity by ~ 100 mAh g−1 at 0.1 A g−1, and the capacity retention is 70.7% after 1000 cycles at 1 A g−1. Multiple in/ex situ characterizations reveal the reversible structural changes during the charging/discharging process. Particularly, benefiting from the mesoporous structure with reduced specific surface area by 31.5 times and less defects, the meso-C generates less irreversible capacity with high ICE up to 76.7%, one of the best reported values so far. This work provides a new perspective that mesopores engineering can effectively accelerate K+ diffusion and enhance K+ adsorption/intercalation storage.
When do Physicians and Nurses Start Communication about Advance Care Planning? A Qualitative Study at an Acute Care Hospital in Japan
Authors: Tsuruwaka Mari , Ikeguchi Yoshiko , Nakamura Megumi 
Published: July 2020

AbstractAlthough advance care planning (ACP) can lead to more patient-centered care, the communication around it can be challenging in acute care hospitals, where saving a life or shortening hospitalization is important priorities. Our qualitative study in an acute care hospital in Japan revealed when specifically physicians and nurses start communication to facilitate ACP. Seven physicians and 19 nurses responded to an interview request, explaining when ACP communication was initiated with 32 patients aged 65 or older. Our qualitative approach employed descriptive analysis to identify major themes, which included “initiation by patients” and “initiation by healthcare professionals.” In the latter case, seven specific triggers were identified: (1) when the patients’ medical condition changed in terms of symptom relief, (2) when the patients’ medical condition changed in terms of prognostic prediction, (3) when serious events occurred, (4) when a choice of treatment was presented, (5) when the location for end-of-life care was chosen, (6) when the patients’ cognitive function deteriorated, and (7) when serious events settled down. Within this group of healthcare professionals, physicians were more focused on changes in their patients’ medical condition, whereas nurses focused more on their patients’ desire for a long-term perspective. Nurses encouraged patients to consider ACP themselves, which developed into an approach to respect patients’ autonomy. In acute care hospitals, it appeared to be desirable to have an early discussion where patients could understand the significance ACP, which would matter even after their discharge from the hospital.
Post-Covid-19 Education and Education Technology ‘Solutionism’: a Seller’s Market
Authors: Teräs Marko , Suoranta Juha , Teräs Hanna , Curcher Mark 
Published: July 2020

AbstractThe Covid-19 pandemic and the social distancing that followed have affected all walks of society, also education. In order to keep education running, educational institutions have had to quickly adapt to the situation. This has resulted in an unprecedented push to online learning. Many, including commercial digital learning platform providers, have rushed to provide their support and ‘solutions’, sometimes for free. The Covid-19 pandemic has therefore also created a sellers’ market in ed-tech. This paper employs a critical lens to reflect on the possible problems arising from hasty adoption of commercial digital learning solutions whose design might not always be driven by best pedagogical practices but their business model that leverages user data for profit-making. Moreover, already before Covid-19, there has been increasing critique of how ed-tech is redefining and reducing concepts of teaching and learning. The paper also challenges the narrative that claims, ‘education is broken, and it should and can be fixed with technology’. Such technologization, often seen as neutral, is closely related to educationalization, i.e. imposing growing societal problems for education to resolve. Therefore, this is a critical moment to reflect how the current choices educational institutions are making might affect with Covid-19 education and online learning: Will they reinforce capitalist instrumental view of education or promote holistic human growth? This paper urges educational leaders to think carefully about the decisions they are currently making and if they indeed pave the way to a desirable future of education.
Alcohol use among 10th‐graders: Distinguishing between high‐intensity drinking and other levels of use
Authors: Mehus Christopher J. , Patrick Megan E. 
Published: July 2020

ABSTRACTIntroductionDrinking at levels beyond standard binge drinking thresholds poses particularly high risks to youth. Few studies have examined high‐intensity drinking (HID; 10+ drinks in a row) in high school students and none have tested whether peer drunkenness and parental knowledge (e.g., about youth's whereabouts) distinguish between binge and high‐intensity drinkers.MethodsWe used data from the Monitoring the Future study collected from nationally‐representative samples of U.S. 10th graders (modal age 16 years old) in 2016–2018 (n = 14,824; 48.3% girls, 46.8% boys). We conducted multinomial logistic regression to examine odds of drinking at one of four mutually‐exclusive levels: HID in the past 2 weeks, binge (5+) drinking in the past 2 weeks, any alcohol use in the past year, and no alcohol use in the past year.ResultsLow parental knowledge and peer drunkenness were both associated with higher odds of each drinking level, including HID vs. binge, binge vs. alcohol use, and alcohol use vs. no alcohol use. Boys had higher odds than girls of HID compared to binge drinking and of no alcohol use compared to alcohol use.ConclusionsParent and peer risk factors differentiate HID from other levels of drinking.
Comprehensive Analysis of lncRNA Expression Pattern and lncRNA–miRNA–mRNA Network in a Rat Model with Cavernous Nerve Injury Erectile Dysfunction
Authors: Cong Rong , Wang Yi , Wang Yamin , Zhang Qijie , Zhou Xiang , Ji Chengjian , Yao Liangyu , Song Ninghong , Meng Xianghu 
Published: July 2020

Abstract

Background
Long noncoding RNAs (lncRNAs) are differentially expressed in erectile dysfunction (ED) associated with aging and diabetes mellitus; however, the lncRNA expression profile in cavernous nerve (CN) injury–related ED (CNI-ED) is unknown.

Aim
To investigate the dysregulated lncRNAs, microRNAs (miRNAs), and mRNA expression in CNI-ED and construct a potential lncRNA–miRNA–mRNA network.

Methods
22 male Sprague–Dawley (SD) rats were divided into bilateral CN crush (BCNC) and Sham groups. Using second-generation high-throughput sequencing technology, we analyzed the expression profiles of lncRNA, miRNA, and mRNA of the 2 groups. 17 differentially expressed lncRNAs were selected and further validated by quantitative real-time polymerase chain reaction (RT-qPCR). The lncRNA–miRNA–mRNA network, Gene Ontology (GO) term enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using Cytoscape.

Outcomes
Intra-cavernosal pressure, mean arterial pressure, smooth muscle content, and the expression of miRNA, mRNA, and lncRNA were measured.

Results
The BCNC group showed decreased intra-cavernosal/mean arterial pressure as well as decreased smooth muscle/collagen ratios compared with the Sham group. The RNA sequencing results revealed dysregulated expressions of 65 lncRNA, 14 miRNA, and 750 mRNA in the BCNC group based on the following criteria: fold change &gt;2 and P &lt; .05. Among the 17 lncRNAs further selected based on mean count number &gt;4 in both groups, 3 lncRNAs (TCONS_00028173, TCONS_00049985, and TCONS_00058429) were further validated for differential expression by RT-qPCR. GO analysis suggests that these 3 lncRNAs could regulate various processes such as myotube differentiation and muscle cell differentiation. Furthermore, the KEGG pathway analysis showed that the mRNAs in the competing endogenous RNA (ceRNA) network are involved in pathways, including axon guidance and vascular endothelial growth factor signaling pathway.

Clinical Translation
Our findings may provide new information on molecular pathophysiology of CNI-ED and suggest further research to find a more effective therapy for CNI-ED.

Strengths & Limitations
This study is the first to identify the lncRNA expression pattern and propose a ceRNA network in a rat model with cavernous nerve injury–related erectile dysfunction. However, analogous studies are needed to confirm these findings in humans. In addition, we constructed the network by only confirming the lncRNA.

Conclusion
Our study reveals differential expression profiles of lncRNAs, miRNAs, and mRNAs between the BCNC and Sham groups and suggests that these differentially expressed lncRNAs may play critical roles in CNI-ED by regulating apoptosis and fibrosis in the corpus cavernosum via targeting mRNAs or miRNAs.
In Vivo Imaging–Based 3-Dimensional Pelvic Prototype Models to Improve Education Regarding Sexual Anatomy and Physiology
Authors: Abdulcadir Jasmine , Dewaele Romain , Firmenich Natacha , Remuinan Jorge , Petignat Patrick , Botsikas Diomidis , Brockmann Céline 
Published: July 2020

AbstractBackgroundMyths, misconceptions, and taboos about sexual anatomy and physiology are common and can affect sexual health and maintain harmful practices and beliefs.AimTo construct a female and a preliminary male 3-dimensional (3D) pelvic model on the basis of in vivo imaging, which could be studied in sex education and clinical practice.MethodsWe retrospectively studied the images of 200 female pelvic magnetic resonance examinations and reviewed the literature to choose the optimum magnetic resonance imaging (MRI) protocol for the study of the clitoris and surrounding organs. We also conducted a cross-sectional study of 30 women who were undergoing a pelvic MRI. 15 women had undergone female genital mutilation/cutting involving the clitoris and 15 had not. The best-quality MRI images of 3 uncut and 1 cut clitoris, together with the principal surrounding pelvic organs, were selected to generate 3D reconstructions using dedicated software. The same software was used to reconstruct the anatomy of the penis and the principal surrounding pelvic organs, based on contrast-enhanced computer tomography images. Images of both models were exported in .stl format and cleaned to obtain single manifold objects in free, open source software. Each organ model was sliced and 3D printed. A preliminary feedback was collected from 13 potential users working in urology, gynaecology, sexual medicine, physiotherapy, and education.OutcomesThe main outcomes of this study are a kit of 3D pelvic models, 2-dimensional figures of female and male sexual anatomy, and files for 3D printing.ResultsWe present a kit containing 3D models and 2-dimensional figures of female and male sexual anatomy, based on in vivo imaging and, feedbacks and suggestions received from potential users.Clinical TranslationOur kit can be used in anatomy and sex education among and by health professionals, teachers, sex educators, students, and the general population.Strengths & LimitationsThe strengths are that the models were based on in vivo imaging, can be dismantled/reassembled, and show analogous anatomic structures of the clitoris and the penis. The female models represent diversity, including women with female genital mutilation/cutting. The limitations are that the male model is preliminary and can be improved if based on an MRI; that imaging-based anatomic representations can differ from anatomic dissections; and that the models represent the sexual organs at rest or during an unknown state of arousal only.ConclusionOur kit can be studied in anatomy, biology, and sex education, as well as in clinical practice.
Symptoms of Problematic Pornography Use in a Sample of Treatment Considering and Treatment Non-Considering Men: A Network Approach
Authors: Bőthe Beáta , Lonza Anamarija , Štulhofer Aleksandar , Demetrovics Zsolt 
Published: July 2020

AbstractBackgroundPornography use may become problematic for 1–6% of the people and may be associated with adverse consequences leading to treatment-seeking behavior. Although the identification of the central symptoms of problematic pornography use (PPU) may inform treatment strategies, no prior study has applied the network approach to examine the symptoms of PPU.AimTo explore the network structure of PPU symptoms, identify the topological location of pornography use frequency in this network, and examine whether the structure of this network of symptoms differs between participants who considered and those who did not consider treatment.MethodsA large-scale online sample of 4,253 men (M age = 38.33 years, SD = 12.40) was used to explore the structure of PPU symptoms in 2 distinct groups: considered treatment group (n = 509) and not-considered treatment group (n = 3,684).OutcomesParticipants completed a self-report questionnaire about their past-year pornography use frequency and PPU measured by the short version of the Problematic Pornography Consumption Scale.ResultsThe global structure of symptoms did not differ significantly between the considered treatment and the not-considered treatment groups. 2 clusters of symptoms were identified in both groups, with the first cluster including salience, mood modification, and pornography use frequency and the second cluster including conflict, withdrawal, relapse, and tolerance. In the networks of both groups, salience, tolerance, withdrawal, and conflict appeared as central symptoms, whereas pornography use frequency was the most peripheral symptom. However, mood modification had a more central place in the considered treatment group’s network and a more peripheral position in the not-considered treatment group’s network.Clinical ImplicationsBased on the results of the centrality analysis in the considered treatment group, targeting salience, mood modification, and withdrawal symptoms first in the treatment may be an effective way of reducing PPU.Strengths & LimitationsThe present study appears to be the first to analyze the symptoms of PPU using a network analytic approach. Self-reported measures of PPU and pornography use frequency might have introduced some biases.ConclusionThe network of PPU symptoms was similar in participants who did and those who did not consider treatment because of their pornography use, with the exception of the mood modification symptom. Targeting the central symptoms in the treatments of PPU seems to be more effective than focusing on reducing pornography use.