bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining fidelity in the INFORM trial, a complex team-based behavioural intervention
Authors: Ginsburg Liane , Hoben Matthias , Easterbrook Adam , Andersen Elizabeth , Anderson Ruth , Cranley Lisa , Lanham Holly , Norton Peter , Weeks Lori , Estabrooks Carole 
Published: March 2020

Abstract
Background Fidelity in complex behavioural interventions is underexplored. This study examines fidelity of the INFORM trial and explores the relationship between fidelity, study arm and the trial’s primary outcome – care aide involvement in formal team communications about resident care. We examined fidelity of intervention delivery, receipt, and enactment. The primary outcome in the INFORM study (care aide involvement in formal team communications about resident care) was also included as an outcome in this fidelity study.Methods A concurrent process evaluation of implementation fidelity was conducted in 33 nursing homes in Western Canada (Alberta and British Columbia). Study participants are from 106 clinical care units clustered in 33 nursing homes randomized to the Basic and Enhanced Assisted Feedback arms of the INFORM trial.Results Fidelity of the INFORM intervention was moderate to high, with fidelity delivery and receipt higher than fidelity enactment for both study arms. Higher enactment teams experienced a significantly larger improvement in formal team communications between baseline and follow-up than lower enactment teams ( F (1, 70) = 4.27, p = .042).Conclusions Overall fidelity enactment was associated with improvements in formal team communications, but study arm was not. This suggests that the intensity with which an intervention is offered and delivered may be less important than the intensity with which intervention participants enact the core components of an intervention. Greater attention to fidelity assessment and publication of fidelity results through studies such as this one is critical to improving the utility of published trials.
Clinical outcomes of Ti-Ni shape-memory patella concentrator combined with cannulated compression screws in the treatment of C2 and C3 patella fracture: a retrospective study of 54 cases
Authors: Chen Yao , Jie Sun , Jiancheng Wu , Zhenyu Zhou , Fan Liu , Ran Tao , Yafeng Zhang 
Published: March 2020

Abstract
Purpose The purpose of this study was to investigate the efficiency of Ti-Ni shape-memory patella concentrator(TNSMPC) combined with cannulated compression screws in the treatment of comminuted patella fracture. Methods Between January 2014 and January 2017, 54 patients of C2 and C3 patella fractures underwent open reduction and internal fixation with TNSMPC combined with cannulated compression screws. All the patients got standard postoperative rehabilitation programs and were regularly followed up for at least 12 months after the operation. X-rays, knee functions and life quality were evaluated during the follow-up. Results All the patients achieved bone healing and recovery of knee function with low incidence of complications according to X-rays and questionnaire surveys. The average operation time and blood loss during surgery were 77.5±25.12minutes and 24.25±4.70ml respectively. The Knee Outcome Survey Activities of Daily Living Scale, range of motion, 36-item Short-form heath survey after the operation were all improved. According to the Bostman’s criteria, the excellent to good rate was 92.6%. Conclusion TNSMPC combined with cannulated compression screws is an effective fixation for C2 and C3 patella fracture with excellent clinical outcomes. In addition, the operation does not increase extra technique difficult or tissue damage relatively, which is worth promotion.
Management of thoracic trauma and analysis of risk factors in thoracic trauma patients
Authors: Beshay Morris , Mertzlufft Fritz , Kottkamp Hans Werner , Vordemvenne Thomas , Reymond Marc , Schmid Ralph Alexander , Branscheid Detlev 
Published: March 2020

Abstract
Objectives:Thoracic trauma (TT) is the third most common cause of death after abdominal injury and head trauma in polytrauma patients. Its management is still a very challenging task. The purpose of this study was to analyse the epidemiological finding, risk factors affecting the outcome in a high volume trauma centre.Patients and methods:Between January 2003 and December 2012 data of all patients admitted to the Accident and Emergency (A&E) were prospectively collected at the German Trauma Registry (GTR) thereafter retrospectively analysed.Patients with chest trauma and Injury Severity Score (ISS) ≥18 and Abbreviated Injury Scale (AIS) >2 in more than one body region were included. Patients were divided into two groups; group I included patients with thoracic trauma between January 2003 to December 2007. The results of this group were compared with the results of other group (group II) in a later five years period (Jan. 2008-Dec. 2012). Univariate and multivariate analysis was done, Statistical difference with P<0.05 were considered significant.Results:There were 630 patients (56%) with thoracic trauma. 540 patients (48%) had associated extra thoracic injuries. Group I consisted of 285 patients (197 male, mean age 46 years). Group II consisted of 345 patients (251 male, mean age 49 year). Overall 90 days mortality was 17% (n=48) in group I vs. 9% (n=31) in group II (p=0.024). Complication rates were higher in group I (p=0.019). Higher injury severity score (ISS), and higher abbreviated injury score (AIS) thoracic showed higher rate of mortality (p<0.0001). Young patients (< 40 years) were frequently exposed to severe thoracic injury but showed less mortality rates (p=0.014). Patients with severe lung contusions (n=94) (15%) had higher morbidity and mortality (p<0.001). 23 (8%) Patients had emergency thoracotomy in group I vs. 14 patients (4%) in group II (p=0.041). Organ replacement procedures were needed in 18% in group I vs. 31% in group II (p=0.038).Conclusions:The presence of severe lung contusion, higher ISS and AISthoracic and advanced age are directly related to higher mortality rate. Instantly management of blunt chest trauma with corrected chest tube insertion, optimal pain control and chest physiotherapy resulted in good outcome in the majority of patients. Optimal management with better survival rates is achievable in specialized centre with a multidisciplinary teamwork and the presence of thoracic surgical experience.
Carcass characteristics and meat quality of male goat kids supplemented by alternative feed resources: Olive cake and cactus cladodes.
Authors: Otmani Samira El , Chebli Youssef , Chentouf Mouad , Hornick Jean-Luc , Cabaraux Jean-François 
Published: March 2020

Abstract
Background The current study was carried out to evaluate the effect of olive cake and cactus cladodes incorporation on carcass characteristics and meat quality of goat kids.Methods Forty-eight male goat kids were divided into four groups. The control group received a conventional supplementation and the test groups were supplemented with a concentrate containing, on dry matter basis, 35% of olive cake (OC), 30% of cactus cladodes (CC), or 15% OC and 15% CC (OC+CC) respectively. After 3 months, all animals were slaughtered and the carcass quality was characterized. Samples of Longissimus dorsi and Semimembranosus were collected to determine meat quality.Results The diets did not affect final body weight and carcass characteristics, except for muscle index that decreases with 35% OC, and redness and yellowness at tail outline and belly (P < 0.05). The OC incorporation increased yellowness at tail and decreased redness at belly (P < 0.05), while the CC inclusion decreased redness at tail outline (P < 0.01), and redness (P < 0.05) and yellowness at belly (P < 0.01). Meat ultimate pH, color, moisture and tenderness were not affected by diets. In Longissimus dorsi, higher proteins (P < 0.001) and lower fat and ash (P < 0.05) content were observed with CC, and lower proteins content with OC and OC+CC (P < 0.001). In Semimembranosus, a low initial pH (P < 0.05) was observed with OC and high protein content (P < 0.001) with CC and OC+CC. Generally, groups, ratios, and indexes of fatty acids (FA) were similar between groups, except FA profile that was affected by diet, especially for Semimembranosus. In Longissimus dorsi, the OC and CC introduction decreased C16:1, and C20: 3n3 increased with CC and OC+CC (P < 0.05). While in Semimembranosus, OC increased C6, C8, C18:3n3, C20:2 and C22:2, whereas CC incorporation reduced C8, C10, and C15:1, and OC+CC reduced C10 (P < 0.05).Conclusions This study was shown that OC and CC could be introduced in goat kids’ diet, without a negative effect on carcass characteristics and meat quality.
Effects of probiotics and Bidens pilosa on the performance and gut health of chicken during induced E. tenella infection
Authors: Memon Fareed Qamar , Yang Yunqio , Lv Feifei , Soliman A.M. , Chen Yunru , Sun Junying , Wang Yuhan , Zhang Geyin , Li Zheng , Xu Baichang , Gadahi Javaid Ali , Si Hongbin 
Published: March 2020

Abstract
Background

Probiotics and Medicinal plants are widely used as an alternative to treat different kinds of the acute and chronic diseases in all over the world. Bidens pilosa is commonly used as foods and therapeutics against various pathogens including protozoan. In the present study probiotics and Bidens pilosa were used to explore the anticoccidial activity during experimental infection of Eimeria tenella ( E. tenella ) in chicken

Methods

One hundred and fifty one-day-old Chinese yellow breed chickens were divided into five equal groups. Group 1 was kept as control group (CG; un-treated, unchallenged). All other groups were inoculated with E. tenella sporulated oocysts on day 21 of age. Group 2 was kept as positive control (CPG; un-treated, challenged). Group 3 was treated with probiotics (PG) at the rate of 1g/kg of feed. Group 4 was treated with Bidens pilosa (BPG) at the dose of 0.5%/kg of feed. Group 5 was kept as probiotics + Bidens pilosa group (PG + BPG). All birds were weighed initially, day of infection and the final day of experiment. On day 5, 6, 7 and 8 post-infection (PI), bloody diarrhea was scored as normal (0) to sever (1, 2, 3 and 4), at the same time oocysts shedding was quantified by McMaster method. Gross caecal lesion scoring was checked at the final day of experiment. The apoptosis related gene expressions (Bcl-2, Bax, Caspase-3), anti-oxidant enzymatic expressions (CAT, SOD 1), Peptide transporter 1 (PepT 1), pro-inflammatory cytokines (IL-6, IL-8) and tight junction proteins expressions (CLDN 1, ZO 1) were checked by real time PCR. All related gene expressions average relative to β-actin was calculated by 2−ΔΔCt method.

Results

Birds treated with probiotics, Bidens pilosa and probiotics + Bidens pilosa slightly increased the body weight gain, significantly reduced oocysts shedding, destructive ratio of ceaca and mortality % than control positive group. CPG birds up-regulated the expressions of Bcl-2 while down-regulated the expressions of Bax and caspase-3 as compared to PG, BPG and PG + BPG groups. Moreover, Eimeria challenged chickens supplemented with probiotics, Bidens pilosa alone and combined showed higher anti-oxidant enzymatic activity than those of challenged un-treated chickens. Additionally, the expressions of pro-inflammatory cytokines and tight junction related proteins were also up-regulated by the treated challenged than un-treated challenged chickens.

Conclusion

Present results revealed that, feed supplementation of probiotics and Bides pilosa induced apoptosis, enhanced anti-oxidant enzymatic activity and pro-inflammatory cytokines as well as tight junction proteins and reduce mortality during E.tenella infection in chickens.
Osteocalcin prevents insulin resistance, hepatic inflammation and autophagy associated with high-fat diet induced fatty liver hemorrhagic syndrome in aged laying hens
Authors: Wu Xiaoling , Zou Xinyu , Zhang Mi , Hu Haiqiang , Wei Xueliang , Jin Meilan , Cheng Hengwei , Jiang Sha 
Published: March 2020

Abstract
Background: Osteocalcin (OCN), as an energy-regulating hormone, involves in preventing nonalcoholic steatohepatitis. Laying hens have been used as an animal model for investigating liver function and related metabolic disordersas that the synthesis of fat in laying hens is much faster than in mammals with limited adipose tissue. The aim of this study was to investigate the effects of OCN on fatty liver hemorrhagic syndrome (FLHS) in aged laying hens. Methods: Thirty 68-week-old White Plymouth laying hens were randomly assigned into conventional single-bird cages, and the cages were randomly allocated into one of three treatments: normal diet (ND + vehicle , ND+V), high-fat diet (HFD + vehicle, HFD+V), and HFD + OCN (3 μg/bird, 1 time/2 days, i.m.) for 40 days. At experimental day 30, oral glucose tolerance tests (OGTT) and insulin tolerance tests (ITT) were performed. At the end of experiment, the hens were euthanized followed blood collection. The plasma aspartate transaminase (AST), alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured using an automatic biochemistry analyzer. Pathological changes in the liver were examined under both light and transmission electron microscopes. The plasma inflammatory factors including interleukin-1 (IL-1), IL-6, and tumor Necrosis Factor-alpha (TNF-α) were analyzed by ELISA, and the gene expressions of these inflammatory factors in the liver were analyzed by Real-time PCR. And oxidative stress was evaluated using Malondialdehyde (MDA) and Glutathione peroxidase (GSH-Px) assay kits. Results: The results showed HFD hens had more severe liver haemorrhage and fibrosis than ND hens. The ultra-microstructural examination showed that hepatocytes of HFD hens appeared necrotic pyknosis associated with great intracellular electron, mitochondrial swelling, shrunk nucleus and absence of autolysosomes. OCN mitigated these pathological changes by improved HFD hens’ insulin resistance via alleviating the glucose intolerence and improving insulin sensitivity; inhibited HFD-induced oxidative stress as evidenced by decreased liver concentrations of MDA but increased GSH-Px; and reduced the inflammatory reaction with reducing blood IL-6 and TNF-α concentrations and mRNA expressions. Conclusion: These results suggest a high-fat diet promotes the FLHS development in aged hens, while OCN prevents the FLHS process through inhibiting insulin resistance, inflammatory reaction, oxidative stress and fibrosis, and acting autophagy.
Physical health symptoms among Ethiopian returnees who were trafficked aboard
Authors: Gezie Lemma Derseh , Atinafu Asmamaw 
Published: March 2020

Abstract
Background: There is a growing thought of considering human trafficking as a severe form of violence which usually results in various health outcomes including symptoms of physical health problems. Physical health symptoms could at least compromise victims’ future quality of life and productivity, and to the worst, it might be life threatening to them. This study examined the magnitude of physical health symptoms during the trafficking period and compared it with that of the period prior to the trafficking condition. Methods : A total of 1387 trafficking returnees from abroad via three trafficking corridors of Ethiopia were recruited consecutively. Among socio-demographic and other characteristics, data regarding physical health symptoms such as headaches, stomach pain, memory problems, back pain, tooth pain, injuries, vision problem, loss of appetite that were experienced during and prior to the trafficking period were collected. The proportions of physical health symptoms experienced during and prior to trafficking period were determined and compared using chi-square test. Results: Among all participants, 598 (46.79%) of them experienced weight loss during the trafficking period while it was only 106 (8.28%) before the trafficking period. The 38.50% extra prevalence of the problem that was experienced during the trafficking period was statistically significant (p< 0.0001). Similar significant differences were observed for symptoms such as forgetfulness (p < 0.0001), stomachache (p = 0.0039), gynecological problems (p = 0.041), bone fracture (p < 0.0001), back pain (p < 0.0001), and wound (p < 0.0001); but not significantly different for symptoms such as skin disease (p-value = 0.1944), tooth pain (p-value =0.6587), sight problem (p-value = 0.1306), and breathing problem (p=value = 0.3173). Conclusions: Returnees experienced higher rate of physical health symptoms during the trafficking period than that of pre-departure period confirming that violence and subsequent health problems are signature features of human trafficking. These negative health outcomes need to be investigated using longitudinal studies so that the long-term effects of human trafficking and associated traumatic experiences could be fully understood among the returnees.
Zinc and cobalt nano ferrites and their potential applications in environmental sustainability
Authors: Hublikar Leena V. , Ganachari Sharanabasava V , Yaradoddi Jayachandra S. , Mokashi Aasim U. 
Published: March 2020

Abstract
Fundamental research and industrially applied research, currently depend on magnetic oxide nanoparticles and ferromagnetic oxides due to their extensive applications for electronic, magnetic, optical sensor and absorptive activities. ferromagnetic substances mainly contain different type of Ferrite. Ferrite material constitutes, Iron oxide (Fe2O3) and divalent metal oxides of Transition metals like cobalt, nickel etc. The key objective of this paper is to study the impending applications of nano - ferrites doped with bivalent transition metals with their properties. Low-Temperature Self-Propagating combustion method was used to synthesize the particles. Synthesized Zinc and Cobalt Nano ferrites from the chemical co-precipitation method were found to be of 20 to 90 nm in average size, and comparative study of their properties using the results of Fourier-transform spectroscopy (FTIR) and X-ray powder diffraction (XRD). The Field Emission Scanning Electron Microscope (FESEM) confirms the conception of ferrite nanoparticles with a structure type cubic spinel. Further comparative Sensing studies showed that the sample displays variation in resistance when gases are passed over the surface, and the change in resistance is observed.
Association between severity of COVID-19 and clinical and biochemical characteristics: a cross-sectional study
Authors: Wang Dan , Li Rui-Fang , Wang Juan , Jiang Qun-Qun , Gao Chang , Yang Juan , Ge Lin-Tong , Hu Qing 
Published: March 2020

Abstract
Background: Coronavirus Disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.Methods: In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.Results： Significantly, disease severity was associated with age (r = 0.458, P < 0.001) , comorbidities (r = 0.445, P < 0.001) , white cell counts (r = 0.229, P = 0.006) , neutrophil count (r = 0.238, P = 0.004) , lymphocyte count (r = -0.295, P < 0.001) , albumin (r = -0.603, P < 0.001) , high-density lipoprotein cholesterol (r= -0.362, P < 0.001) , serum potassium (r = -0.237, P = 0.004) , plasma glucose (r = 0.383, P < 0.001) , total bilirubin (r = 0.340, P < 0.001) , serum amyloid A (r = 0.58, P < 0.001) , procalcitonin (r = 0.345, P < 0.001) , C-reactive protein ( r = 0.477, P < 0.001) , lactate dehydrogenase (r = 0.548, P < 0.001) , aspartate aminotransferase (r = 0.342, P < 0.001) , alanine aminotransferase (r = 0.264, P = 0.001) , erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P ＜ 0.001) .Conclusion: With following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 ug/mL, serum amyloid A > 100.02 mg/L, or albumin ＜ 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium and procalcitonin may also be a prognostic indicator.
The Associations between Meeting the 24-Hour Movement Guidelines and Adiposity in Asian Adolescents: The Asia-Fit Study
Authors: Hui Stanley , Zhang Ru , Suzuki Koya , Naito Hisashi , Balasekaran Govindasamy , Song Jong-Kook , Park Soo Yeon , Liou Yiing-Mei , Lu Dajiang , Poh Bee Koon , Kijboonchoo Kallaya , Thasanasuwan Wiyada 
Published: March 2020

Abstract
Background: To prevent adolescent obesity, recent research suggests that physical activity (PA), recreational screen-time, and sleep duration are codependent behaviours that being in a movement behaviour continuum in a 24-hour period. Yet, it is unknown about compliance with the 24-hour movement guidelines in Asian adolescents, and how these movement behaviours collectively affect overweight and obesity in adolescents. The purposes of this study were to compare compliance with the 24-movement guidelines in Asian adolescents, as well as to examine the association between meeting the 24-hour movement guidelines and body fat percentage. Methods: A sample of 12,590 adolescents aged 13.63 (± 1.01) years from eight Asian metropolitan cities including Bangkok (Thailand), Hong Kong SAR, Kuala Lumpur (Malaysia), Seoul (South Korea), Shanghai (China), Singapore, Taipei (Taiwan), and Tokyo (Japan) participated this study. The adolescents were asked to complete an interviewer-administered questionnaire to assess moderate-to-vigorous PA, recreational screen-time, sleep duration, and covariates. Adolescent’s body fat percentage was assessed using bioelectrical impedance analysis.Results: Findings show that a small proportion of Asian adolescents met the independent or combined guidelines of PA, recreational screen-time, and sleep duration. In addition, number of the guideline being met and combinations of the guidelines being met differed across the eight cities. Adjusting for covariates, we observed a negative association between number of the guidelines being met and body fat percent in Asian adolescents. In addition, meeting only the sleep duration guideline and both the physical activity and sleep duration guidelines had negative associations with body fat percentage compared with no guidelines being met.Conclusions: The current study was the first to evaluate compliance with the 24-hour movement guidelines in Asia-wide adolescents. Given only 1%-3% adolescents met all three movement guidelines, global strategies are needed to promote healthy lifestyles in adolescents. This study also provides primary evidence on the association between compliance with the 24-hour movement guidelines and adiposity in adolescents. Prospective follow-up studies are warranted to gain better insights into the compliance with 24-hour movement guidelines and the related health outcomes to contribute to the growth of evidence in this area.