bluuebunny/crossref_metadata_2025_split huggingface dataset:
Midlife Modifiable Risk Factors for Dementia: A Systematic Review and Meta-analysis of 34 Prospective Cohort Studies
Authors: Li Xiao-Ying , Zhang Min , Xu Wei , Li Jie-Qiong , Cao Xi-Peng , Yu Jin-Tai , Tan Lan 
Published: January 2020

Objective:The aim of this study is to assess the association between midlife risk factors and dementia.Methods:PubMed and Cochrane library were systematically searched on May 24, 2018, to retrieve prospective cohort studies. The summary Relative Risk (RR) and 95% Confidence Interval (CI) were calculated by the random-effect model to explore the association between midlife risk factors and dementia. Sensitivity analysis and meta-regression were conducted to explore the source of heterogeneity. Publication bias was examined using Begg's and Egger's tests.Results:Thirty-four prospective cohort studies were included, among which 24 were eligible for metaanalysis. A total of 159,594 non-demented adults were enrolled at baseline before 65 years and 13,540 people were diagnosed with dementia after follow-up. The pooled results revealed that five factors could significantly increase the dementia risk by 41 to 78%, including obesity (RR, 1.78; 95% CI: 1.31-2.41), diabetes mellitus (RR, 1.69; 95% CI: 1.38-2.07), current smoking (RR, 1.61; 95%, CI: 1.32-1.95), hypercholesterolemia (RR, 1.57; 95% CI: 1.19-2.07), and hypertension (borderline blood pressure RR, 1.41; 95% CI: 1.23-1.62 and high Systolic Blood Pressure (SBP) RR, 1.72; 95% CI: 1.25-2.37). However, the sensitivity analyses found that the results of hypercholesterolemia and high SBP were not reliable, which need to be confirmed by more high-quality studies. No influences due to publication bias were revealed. In the systematic review, another three factors (hyperhomocysteinemia, psychological stress, and heavy drinking) were found to be associated with elevated dementia risk. In addition, physical exercise, a healthy diet, and hormone therapy in middle age were associated with the reduction of dementia risk.Conclusions:Middle-aged people with obesity, diabetes, hypertension, or hypercholesterolemia, and current smokers in midlife are at higher risk of developing dementia later in life.
Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan
Authors: Zhang Han-Wei , Kok Victor C. , Chuang Shu-Chun , Tseng Chun-Hung , Lin Chin-Teng , Li Tsai-Chung , Sung Fung-Chang , Wen Chi P. , Hsiung Chao A. , Hsu Chung Y. 
Published: January 2020

Background:
Alzheimer’s disease, the most common cause of dementia among the elderly, is
a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have
adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger
a dementia event.

Objective:
We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the
risk of developing dementia.

Method:
The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox
proportional hazards regression analysis was used to fit the multiple pollutant models for two targeted
pollutants, including total hydrocarbons and non-methane hydrocarbons, and estimated the risk of dementia.

Results:
Before controlling for multiple pollutants, hazard ratios with 95% confidence intervals for the
overall population were 7.63 (7.28-7.99, p <0.001) at a 0.51-ppm increases in total hydrocarbons, and
2.94 (2.82-3.05, p <0.001) at a 0.32-ppm increases in non-methane hydrocarbons. The highest adjusted
hazard ratios for different multiple-pollutant models of each targeted pollutant were statistically significant
(p <0.001) for all patients: 11.52 (10.86-12.24) for total hydrocarbons and 9.73 (9.18-10.32) for
non-methane hydrocarbons.

Conclusion:
Our findings suggest that total hydrocarbons and non-methane hydrocarbons may be contributing
to dementia development.
Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent
Authors: Shirbhate Ekta , Divya  , Patel Preeti , K. Patel Vijay , Veerasamy Ravichandran , Sharma Prabodh C. , Rajak Harish 
Published: January 2020

Aim:
To predict the most potent indole based HDAC2 inhibitors from several scientific
reports through the process of lead identification and SAR development.
Background: The current scenario is observing Histone Deacetylase (HDAC) as an alluring
molecular target for the designing and development of drugs for cancer treatment.

Background:
The current scenario is observing Histone Deacetylase (HDAC) as an alluring
molecular target for the designing and development of drugs for cancer treatment.

Objective:
To identify the lead and establish structure-activity correlation among indole based
hydroxamic acid to find out promising HDAC2 based anticancer agent.

Methods:
A dataset containing 59 molecules was analyzed using structure and ligand-based
integrated approach comprising atom-based 3D-QSAR (Quantitative Structure-Activity
Relationship) and pharmacophore study, e-pharmacophore mapping and molecular modeling
methodologies. The finest model was prepared by amalgamating the properties of electronegativity,
polarizability, Vander Waals forces and other conformational aspects.

Results:
The result of 3D QSAR analysis, performed for 4 PLS factor, provided the following
statistical information: R2 = 0.9461, Q2 = 0.7342 and low standard of deviation SD = 0.1744 for
hypothesis ADDDH.10 and R2 = 0.9444, Q2= 0.7858 and again low standard of deviation
SD = 0.1795 for hypothesis DDHRR.12. The XP molecular docking showed intermolecular
interactions of small molecules with amino acids such as GLY154, HIP145, PHE210, HIE183,
internal H2O and Zn2+.

Conclusion:
The interpretation of data generated as a result of this investigation clearly hints about
the better biological activity of test compounds as compared to SAHA. Hence, the outcome of these
structure and ligand-based integrated studies could be employed for the design of novel arylindole
derivatives as a potent HDAC inhibitor.
Cardiovascular Risk Prediction using JBS3 Tool: A Kerala based Study
Authors: Paul Paulin , George Noel , Shan B. Priestly 
Published: January 2020

Background:
Accuracy of Joint British Society calculator3 (JBS3) cardiovascular (CV)
risk assessment tool may vary across the Indian states, which is not verified in south Indian, Kerala
based population.

Objectives:
To evaluate the traditional risk factors (TRFs) based CV risk estimation done in Kerala
based population.

Methods:
This cross-sectional study uses details of 977 subjects aged between 30 and 80 years,
recorded from the medical archives of clinical locations at Ernakulum district, in Kerala. The risk
categories used are Low (<7.5%), Intermediate (≥7.5% and <20%), and High (≥20%) 10-year risk
classifications. The lifetime classifications are Low lifetime (≤39%) and High lifetime (≥40%) are
used. The study evaluated using statistical analysis; the Chi-square test was used for dependent and
categorical CV risk variable comparisons. A multivariate ordinal logistic regression analysis for the
10-year risk and odds logistic regression analysis for the lifetime risk model identified the
significant risk variables.

Results:
The mean age of the study population is 52.56±11.43 years. With 39.1% in low, 25.0% in
intermediate, and 35.9% has high 10-year risk. Low lifetime risk with 41.1%, the high lifetime risk
has 58.9% subjects. The intermediate 10-year risk category shows the highest reclassifications to
High lifetime risk. The Hosmer-Lemeshow goodness-of-fit statistics indicates a good model fit.

Conclusion:
Timely interventions using risk predictions can aid in appropriate therapeutic and lifestyle
modifications useful for primary prevention. Precaution to avoid short-term incidences and
reclassifications to a high lifetime risk can reduce the CVD related mortality rates.
Synthesis and In vitro Antibacterial, Antitubercular Studies of Novel Fluoroquinolones Analogs Containing 4-substituted Sec Amine
Authors: Akula Ravi K. , Pamulaparthy Shanthan R. , Koochana Pranay K. , Sriram Dharmarajan 
Published: January 2020

Background:Tuberculosis is a contagious, air borne disease and second leading cause of death among infectious diseases worldwide. Fluoroquinolones are well-known antibacterial agents and they were recommended as second-line of antitubercular drugs.Method:A series of novel fluoroquinolone analogs 6-24 was effectively synthesized. An attempt was made by tagging the substituted pyrazole on to fluoroquinolones for the first time at C-7 position. The newly synthesized compounds were characterized by FTIR, 1HNMR, ESI-MS, HR-MS and elemental analysis. The in vitro antibacterial activity of all the title compounds was investigated against various gram positive, gram negative bacterial organisms and in vitro antitubercular activity against Mycobacterium Tuberculosis H37Rv strain.Result:Most of the synthesized compounds showed comparable activity against the entire gram positive and gram negative bacterial organisms. Fluoroquinolone 16 showed enhanced activity against both type of bacterial strains and compound 11showed promising activity against MTB-H37Rv strain.Conclusion:Some of the novel fluoroquinolone analogs (11, 16) showed potent antibacterial, antitubercular activity.
METODOLOGI PENCIPTAAN KARYA TARI SURAU
Authors: Anughara Fattahul , Martion Martion , Nursyirwan Nursyirwan 
Published: January 2020

AbstrakKarya tari Surau merupakan sebuah transformasi budaya ke dalam bentuk seni pertunjukan. Karya ini terinspirasi dari persoalan nilai pendidikan di Surau, didalamnya terdapat nilai sosial budaya dan agama. Surau merupakan lembaga pendidikan untuk anak laki-laki di Minangkabau, dapat dilihat bahwa seorang laki-laki dididik sejak dini untuk bisa membekali dirinya sehingga ilmu dan keterampilan yang didapat bisa berguna saat mereka dewasa dan akan pergi merantau. Tujuan dari penulisan artikel ini agar mengetahui metode penciptaan dan bentuk garapan dari karya tari Surau. Metode penelitian yang digunakan dalam penulisan ini ialah penelitian kualitatif dengan konsep historis. Teknik pengnumpulan data berupa pengamatan berpartisipasi, wawancara, analisis dokumen, menilai, membuktikan serta mensintesiskan dari bukti lapangan. Hasil dari penelitian ini dapat membuktikan bahwa bentuk transformasi karya tari Surau merupkan hasil dari sebuah metodologi penciptaan sebuah karya.Kata Kunci: surau, metodologi penciptaan, bentuk garapan.AbstractSurau dance work is a cultural transformation into the form of performing arts. This work is inspired by the issue of the value of education in Surau, in which there are socio-cultural and religious values. Surau is an educational institution for boys in Minangkabau, it can be seen that a man is educated early to be able to equip himself so that the knowledge and skills acquired can be useful when they are adults and will go abroad. The purpose of writing this article is to find out the method of creation and the form of cultivation from Surau dance works. The research method used in this writing is qualitative research with historical concepts. The technique of collecting data in the form of participatory observations, interviews, document analysis, evaluating, proving and synthesizing from field evidence. The results of this study can prove that the form of transformation of Surau dance works is the result of a methodology of creating a work. Keywords: surau, creation methodology, form of cultivation
GAYA BELAJAR AURAL PLAY DI YAMAHA MUSIK PADANG
Authors: Saputra Wahyu Eka , Efi Agusti 
Published: January 2020

AbstrakPenelitian ini bertujuan untuk mengetahui pelaksanaan pembelajaran gaya belajar aural play di Yamaha musik Padang. Metode yang digunakan dalam mengetahui pelaksanaan pembelajaran aural play di Yamaha musik Padang ini adalah metode kualitatif natural observasi, dimana peneliti sebagai instrument utama penelitian. Siswa Yamaha musik padang memiliki kecendrungan menggunakan indra pendengaran untuk belajar dan mempraktekkan alat musik dengan menirukan kembali apa saja yang dilakukan oleh guru mereka. Walaupun telah adanya buku penunjang berisi notasi musik yang dipelajari dengan cara membaca, siswa lebih senang mendengarkan dan menirukan cara guru mereka mempraktekan materi musik yang sedang dipelajarinya. Oleh sebab itu perlu untuk dicari tahu kenapa siswa Yamaha musik padang sangat cendrung menggunakan gaya belajar aural play dalam mempelajari dan mempraktekkan instrument musik mereka. Penelitian ini diharapkan dapat menambah wawasan kajian pembelajaran musik tentang penerapan gaya belajar aural kepada siswa di lembaga pendidikan musik, mampu memperkaya teori tentang gaya belajar aural dan terhadap pengembangan ilmu pengetahuan yang berkaitan dengan gaya belajar aural. Kata Kunci: gaya belajar, musik, aural, play.AbstractThis research study is to study the implementation of aural play style learning in Yamaha Padang music. The method used in studying the implementation of learning to play in Yamaha Padang music is a qualitative method of natural observation, where the researcher as the main research instrument. Yamaha Padang students have a tendency to use the sense of hearing to learn and practice musical instruments by imitating whatever their teacher does. Although there are supporting books containing music notation that are learned by reading, students prefer to listen and imitate the way their teacher practices the music material that they are learning. Therefore it is necessary to know why Yamaha Padang students are so inclined to use aural learning learning styles in discussions and practice their musical instruments. This research is expected to add insight into music learning about the application of aural learning styles to students in music education institutions, able to enrich theories about aural learning styles and to the development of knowledge related to aural learning styles. Keywords: learning style, music, aural, play.
PARENTING STRESS DAN PARENTING ALLIANCE PADA IBU YANG MENJADI WARGA BINAAN PEMASYARAKATAN
Authors: Andriani Dhini , Sumintardja Elmira N , Abdurachman Muniroh 
Published: January 2020

Selama berada di lapas Ibu yang menjadi WBP harus berpisah dengan anak mereka dan tidak dapat mengasuh anak secara langsung, serta harus membangun hubungan dengan pengasuh anak mereka. Penelitian ini bertujuan untuk mengetahui bagaimana gambaran parenting stress dan parenting alliance serta korelasi diantara keduanya pada Ibu yang menjadi Warga Binaan Pemasyarakatan (WBP). Pengukuran menggunakan Parenting Stress Index (PSI) dan parenting Alliance Measure (PAM). Total partisipan penelitian adalah 43 incarcerated mother. Analisa data menggunakan statistik deskriptif dan korelasi Spearman rho. Ibu yang menjadi WBP memiliki parenting stress yang cenderung rendah. Hal ini berarti meskipun berada di Lapas, para Ibu yang menjadi WBP memiliki sumberdaya yang cukup untuk dapat menjalankan tuntutan sebagai orang tua. Diantara tujuh dimensi pada parenting stress, hanya dimensi depression bernilai tinggi. Hal ini menunjukkan mereka Ibu yang menjadi WBP merasakan perasaan bersalah karena tidak dapat mengasuh anak secara langsung dan tidak merasa puas menjalankan peran sebagai orang tua. Ibu yang menjadi WBP memiliki penilaian yang tinggi terhadap parenting alliance yang dibentuk dengan pengasuh anak. Hal ini berarti mereka merasakan adanya komunikasi dan kerjasama, serta komitmen dari pengasuh anak. Hasil menunjukkan bahwa tidak terdapat hubungan yang signifikan antara parenting stress dan parenting alliance pada Ibu yang menjadi WBP. Saran penelitian selanjutnya adalah tidak hanya mengukur Ibu yang menjadi WBP, tapi juga mengukur parenting alliance pada pengasuh anak, serta bagaimana penyesuaian diri anak terhadap perpisahan dengan ibu karena pemenjaraan.
Geographic trends in range sizes explain patterns in bird responses to urbanization in Europe
Authors: Ferenc Michal , Sedláček Ondřej , Fuchs Roman , Fraissinet Maurizio , Storch David 
Published: January 2020

Abstract
The probability of occurrence of bird species in towns/cities increases with their range sizes, and Rapoport’s rule states that range sizes increase with latitude. To test the hypothesis that the increasing number of bird species persisting in cities at higher latitudes of Europe is linked to their larger range sizes, we compiled data on bird communities of: a) 41 urban bird atlases; b) 37 city core zones from published sources; c) regions of nine grid cells of the EBCC Atlas of European Breeding Birds around each city. We tested whether the proportion of species from particular regional bird assemblages entering cities (i.e., proportional richness) was related to the geographical position, mean range size of regional avifaunas, proportion of vegetated areas and city habitat heterogeneity. The mean range sizes of the observed and randomly selected urban avifaunas were contrasted. The proportional richness of urban avifaunas was positively related to the geographic position and mean range size of birds in regional assemblages. The evidence favoured range sizes if considering the European range sizes or latitudinal extents, but was limited for global range sizes. Randomizations tended to show larger range sizes for the real avifaunas than in the randomly selected ones. For urban core zones, the results were less clear-cut with some evidence only in favour of the European range sizes. No role of vegetation or habitat heterogeneity was found. In conclusion, while vegetation availability or heterogeneity did not show any effects, spatial position and range sizes of birds in regional assemblages seemed to influence the proportional richness of cities and their core zones. Factors correlated with spatial position (e.g., climate) might increase the attractivity of particular cities to birds. However, the effects of range sizes indicated that urbanization possibly has more negative impacts on the avifauna in the regions occupied by less widespread species.
Nursing students’ experiences of caring for dying patients and their families: a systematic review and meta-synthesis
Authors: Wang Yan 
Published: January 2020

Abstract

Objective
Nurses play important roles in caring for dying patients and their families. Difficulties students confronted when facing dying patients challenge the quality of nursing education. A better understanding of students’ experiences would enhance teachers’ ability in helping students. This study aims to describe available evidence about nursing students’ experiences when caring for dying patients and their families.

Methods
A review of qualitative studies published between 2005 and 2017 was undertaken using the following databases: MEDLINE, CINAHL, ProQuest Central, ScienceDirect, and CNKI. The keywords included were nursing students, experience, care, end-of-life, and dying. Qualitative Assessment and Review Instrument was used to assess the quality of the studies by two independent reviewers. The data from the studies were analyzed by meta-synthesis.

Results
Eighteen English and two Chinese studies were selected in this review. Four themes were emerged: (1) Students with dying patients: students did not have enough ability in symptoms control, comfort supply, and therapeutic communication for dying patients. (2) Students with the patients’ families: students advocated more caring for patients’ families. (3) Students with the surroundings: professional medical staffs, especially the nursing preceptors, were key roles in constructing a supporting system for students. (4) Students with themselves: nursing students underwent various negative feelings and adopted both negative and positive strategies to cope with such feelings; students experienced professional and personal development during the caring for dying patients.

Conclusions
Nursing students’ abilities in terminal symptom control, comfort supply, and therapeutic communication should be improved by more theoretic learning and simulation practice. The nursing preceptors were key roles in constructing a supporting system for students and helping them to control the negative emotions when facing dying patients.
Awareness and knowledge of human papillomavirus vaccination and their influential factors among Chinese women: a systematic review
Authors: Tang Gui-Dan , Zeng Gu-Qing , Zhao Bi-Xia , Li Yun-Li , Wang Rong , Wan Yan-Ping 
Published: January 2020

Abstract

Objectives
To systematically review the knowledge attitudes and the influential factors on human papillomavirus (HPV) vaccination among Chinese women.

Methods
Published studies on knowledge and attitudes of HPV vaccination for preventing cervical cancer among Chinese female population were retrieved using the major Chinese and English databases. Meanwhile, handwork retrieval was also conducted and the references including in the literature were retrieved. The quality of the literature was rigorously evaluated and extracted independently by two researchers and the data were analyzed and described by review manager 5.3 (RevMan5.3) software.

Results
In all, 19 articles including 8 articles in Chinese and 11 in English were chosen. A total of 30,176 participants were included and the sample size ranged from 64 to 6,024. The overall awareness of HPV and HPV vaccine among Chinese women was at a low level. Chinese women generally showed poor knowledge about HPV and HPV vaccine. Acceptance of HPV vaccination among Chinese women was at a high level. Vaccination intentions were influenced by the theory of planned behavior (TPB) and measured by attitudes subjective norms and perceived behavioral control.

Conclusions
The health authorities may evaluate and develop TPB-based interventions to increase HPV vaccination intentions of Chinese women. HPV vaccination programs should focus on carrying out multi-level and targeted health education and developing effective public health strategies after balancing the cost and benefit of HPV vaccine program. Medical staff should play the positive role in promoting the use of HPV vaccines in China. Integration of policy and community perspectives and multi-level interventions are essential to maximize the public health benefits of HPV vaccination.
Managerial Communication System for the Operation of Learning Acceleration Programs
Authors: Huda Miftakhul 
Published: January 2020

Research on managerial communication in special classes was essential because it has unique characteristics and need specialized administrative too. This study aimed to find out the mixture of communication in the managerial communication system for the implementation of accelerated classes at State Senior High School 3 Surakarta. The type of this research was descriptive qualitative. The research subjects consisted of the school principals, the administrators of the acceleration program, and the parents of accelerated students at State Senior High School 3 Surakarta. The Data collection techniques in this study used interview, observation, and documentation techniques. The mixture of communication, which was consists of four components, those are advertising (socialization), personal sales, sales promotion, and public relations contained in the managerial communication system for the acceleration of learning programs. There were three forms of socialization programs for accelerating programs; visiting schools, maximizing brochures and web utilization. Types of socialization itself include selective demand advertising and indirect socialization. Based on the school's potential, a socialization model can be developed in the form of making school magazines, parent/guardian forums, and holding event activities.
Keywords: Managerial Communication System, Operation of Learning Acceleration Programs