bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Qué opinan los universitarios sobre el uso académico de las redes sociales?
Authors: Abelairas-Etxebarria Patricia , Mentxaka Arana Jon 
Published: July 2020

Hoy en día, las redes sociales son utilizadas en cualquier momento y en cualquier lugar. Entre los jóvenes, en particular, han supuesto una revolución a la hora de relacionarse. Sin embargo, dichas redes sociales tienen escasa presencia en el aula universitaria para su uso académico.
Este trabajo pretende analizar el uso de las redes sociales de los estudiantes de la Facultad de Economía y Empresa de la Universidad del País Vasco/Euskal Herriko Unibertsitatea. Además, se analiza la opinión de los alumnos y alumnas sobre la posibilidad de introducir las redes sociales en el aula con fines académicos. Con estos objetivos, se ha realizado una encuesta a una muestra de los estudiantes de dicha facultad donde, como principal resultado, se extrae que la gran mayoría de los estudiantes usan habitualmente las redes sociales en el ámbito personal y que están dispuestos a introducir estas redes sociales como herramienta en el aula universitaria.
At the present time, social networks are used anytime and anywhere. Among young people, in particular, they have been a revolution when it comes to socializing. However, these social networks have little presence in the university classroom for an academic use.
This paper aims to analyze the use of social networks of students of the Faculty of Economics and Business of the University of the Basque Country / Euskal Herriko Unibertsitatea. In addition, it analyzes the opinion of the students about the possibility of introducing social networks in the classroom for academic purposes. With these objectives a survey has been carried out on a sample of the students of said faculty where, as the main result, it is extracted that the vast majority of students routinely use social networks in the personal sphere and that they are willing to introduce these social networks as a tool in the university classroom.
Diagnosis of heart failure in elderly patients in primary care
Authors: Owen Andrew , Cox Stephen 
Published: July 2002

AbstractBackground:Heart failure is difficult to diagnose in a primary care setting with a reported false positive diagnosis in up to 70% of cases.Aims:To use echocardiography in a large rural practice to evaluate the accuracy of diagnosis of heart failure in patients over 65 years of age.Methods:Sixty patients with a previous diagnosis of heart failure were selected at random from the practice records and were invited to attend for an echocardiogram at the practice premises.Results:Fifty‐eight patients attended, the age was 81±7 years, 29% had impaired left ventricular (LV) systolic function of whom 65% were in atrial fibrillation. A further 7% had isolated diastolic LV dysfunction. The prevalence of heart failure by clinical assessment was 29 per 1000 in this patient group and 9 per 1000 when echocardiography was used to confirm the diagnosis.Conclusion:True heart failure in this population is less prevalent than has been estimated from practice records.
Nanoconfined (Bio)Catalysts as Efficient Glucose‐Responsive Nanoreactors
Authors: Rodriguez‐Abetxuko Andoni , Muñumer Pablo , Okuda Mitsuhiro , Calvo Javier , Knez Mato , Beloqui Ana 
Published: July 2020

AbstractHerein, the design, synthesis, and characterization of bifunctional hybrid nanoreactors used for concurrent one‐pot chemoenzymatic reactions are shown. In the design, the enzyme, glucose oxidase, is wrapped with a peroxidase‐mimetic catalytic polymer. Hemin, the organic catalyst, is linked to the flexible polymeric scaffold through coordination to the imidazole groups that hang out the network. This spatial arrangement, which works as a metabolic channel, is optimized for cooperative chemoenzymatic reactions in which the enzyme catalyzes first. A deep characterization of the integrated nanoreactors demonstrates that the confinement of two distinct catalytic sites in the nanospace is very effective in one‐pot reactions. Moreover, besides its role as scaffold material, the polymeric mantel protects both the biocatalyst and the chemical catalyst from degradation and inactivation in the presence of organic solvents. Furthermore, the polymeric environment of the nanoreactors can be tailored in order to trigger the assembly of those into highly active heterogeneous hybrid catalysts. Finally, the new nanoreactors are applied to the efficient degradation of organic aromatic compounds using glucose as the only fuel.
Shining Light on Poly(ethylene glycol): From Polymer Modification to 3D Laser Printing of Water Erasable Microstructures
Authors: Houck Hannes A. , Müller Patrick , Wegener Martin , Barner‐Kowollik Christopher , Du Prez Filip E. , Blasco Eva 
Published: July 2020

AbstractThe implementation of stimuli‐responsive bonds into 3D network assemblies is a key concept to design adaptive materials that can reshape and degrade. Here, a straightforward but unique photoresist is introduced for the tailored fabrication of poly(ethylene glycol) (PEG) materials that can be readily erased by water, even without the need for acidic or basic additives. Specifically, a new class of photoresist is developed that operates through the backbone crosslinking of PEG when irradiated in the presence of a bivalent triazolinedione. Hence, macroscopic gels are obtained upon visible light‐emitting diode irradiation (λ > 515 nm) that are stable in organic media but rapidly degrade upon the addition of water. Photoinduced curing is also applicable to multiphoton laser lithography (λ > 700 nm), hence providing access to 3D printed microstructures that vanish when immersed in water at 37 °C. Materials with varying crosslinking densities are accessed by adapting the applied laser writing power, thereby allowing for tunable hydrolytic erasing timescales. A new platform technology is thus presented that enables the crosslinking and 3D laser printing of PEG‐based materials, which can be cleaved and erased in water, and additionally holds potential for the facile modification and backbone degradation of polyether‐containing materials in general.
A General Approach to O‐Sulfation by a Sulfur(VI) Fluoride Exchange Reaction
Authors: Liu Chao , Yang Cangjie , Hwang Seung , Ferraro Samantha L. , Flynn James P. , Niu Jia 
Published: July 2020

AbstractO‐sulfation is an important chemical code widely existing in bioactive molecules, but the scalable and facile synthesis of complex bioactive molecules carrying O‐sulfates remains challenging. Reported here is a general approach to O‐sulfation by the sulfur(VI) fluoride exchange (SuFEx) reaction between aryl fluorosulfates and silylated hydroxy groups. Efficient sulfate diester formation was achieved through systematic optimization of the electronic properties of aryl fluorosulfates. The versatility of this O‐sulfation strategy was demonstrated in the scalable syntheses of a variety of complex molecules carrying sulfate diesters at various positions, including monosaccharides, disaccharides, an amino acid, and a steroid. Selective hydrolytic and hydrogenolytic removal of the aryl masking groups from sulfate diesters yielded the corresponding O‐sulfate products in excellent yields. This strategy provides a powerful tool for the synthesis of O‐sulfate bioactive compounds.
Cell Cycle Synchronization of the Murine EO771 Cell Line Using Double Thymidine Block Treatment
Authors: Goepp Marie , Le Guennec Delphine , Rossary Adrien , Vasson Marie‐Paule 
Published: July 2020

AbstractThis study shows that double thymidine block treatment efficiently arrests the EO771 cells in the S‐phase without altering cell growth or survival. A long‐term analysis of cell behavior, using 5(6)‐carboxyfluorescein diacetate N‐succinimidyl ester (CFSE) staining, show synchronization to be stable and consistent over time. The EO771 cell line is a medullary breast‐adenocarcinoma cell line isolated from a spontaneous murine mammary tumor, and can be used to generate murine tumor implantation models. Different biological (serum or amino acid deprivation), physical (elutriation, mitotic shake‐off), or chemical (colchicine, nocodazole, thymidine) treatments are widely used for cell synchronization. Of the different methods tested, the double thymidine block is the most efficient for synchronization of murine EO771 cells if a large quantity of highly synchronized cells is recommended to study functional and biochemical events occurring in specific points of cell cycle progression.
A novel stability‐indicating analytical method development for simultaneous determination of carboplatin and decitabine from nanoparticles
Authors: Esim Ozge , Gumustas Mehmet , Hascicek Canan , Ozkan Sibel A. 
Published: July 2020

AbstractDrug resistance is one of the main problems of cancer treatment. For this reason, combination therapy is commonly used for years. The combination of a chemotherapeutic, carboplatin, and the epigenetic drug decitabine is a new approach to modulate drug resistance. Nanoparticulate systems can overcome the drawbacks associated with the drug combinations. An analytical method that can detect and quantify carboplatin and decitabine which is encapsulated into the nanoparticles is necessary for nanoparticle development. In the literature, there is no analytical method in which carboplatin and decitabine are determined simultaneously. The primary purpose of this study is to develop and validate a novel, and stability‐indicating high‐performance liquid chromatography method for simultaneous determination of carboplatin and decitabine in pharmaceutical preparations in addition to developing the first nanoformulation for this drug combination. Therefore, various experimental parameters were optimized. The chromatographic separation was achieved using an XSelect® CSH C18 (250 × 4.6 mm I.D., 5 µm) column and a mobile phase consisting of methanol:water (containing 0.1% phosphoric acid) (3:97, v/v). The mobile phase pH was adjusted to 7.0 with 5 M NaOH. The developed method was successfully applied for the simultaneous determination and quantification of carboplatin and decitabine co‐encapsulated in nanoparticles and released into in vitro dissolution medium.
pH‐responsive chitosan/sulfobutyl ether‐β‐cyclodextrin supramolecular nanoparticles for controlled release of sodium ferulate
Authors: Yue Lulu , Jin Wen , Chi Shaoming , Yang Tong , Lei Ze , Zhu Hongyou , Zhao Yan 
Published: July 2020

AbstractA pH‐responsive supramolecular nanoparticles was constructed through the electrostatic interaction from anionic sulfobutyl ether‐β‐cyclodextrin (SBE7‐β‐CD) and two positively charged chitosan (CS‐75% and CS‐95%). The prepared nanoparticles were characterized by UV‐vis absorption spectra, x‐ray diffraction, dynamic light scattering, transmission electron microscopy, and zeta potential. It was found that the CS/SBE7‐β‐CD nanoparticles can be disassembly by increasing pH value and reassembled by reducing to the original pH value. To explore the potential of the obtained nanoparticles as a drug delivery vehicle, a negatively charged anticardio cerebrovascular drug sodium ferulate (SF) was loaded. The result indicated that the SF could be efficiently encapsulated in its nanoparticle nucleus under simulated gastric conditions with lower pH (pH 2.0), while effective release is triggered in a simulated intestinal environment with higher pH (pH 8.5). The assembly/disassembly behavior and drug loading/release property make CS/SBE7‐β‐CD nanoparticles promising candidates for pH stimulation responsive drug delivery system, which has a broad application prospect in the treatment of cardiovascular and cerebrovascular diseases, diabetes and other chronic diseases.
Vertical deformation analysis of a high‐rise building with high‐position connections
Authors: Ma Lu , Bai Yabo , Zhang Ji 
Published: July 2020

SummaryIn this paper, a high‐rise frame‐core tube structure with strengthened stories and high‐position connections, a new landmark building in Wuhan, whose height is 238.6 m, is selected as an example. Construction simulation analysis is carried out by the finite element analysis software ETABS to study the vertical deformation and deformation difference of vertical members under the gravity load, taking the influence of construction processes and shrinkage and creep of concrete into consideration. The results show that there is a significant difference between the vertical deformation of the twin‐tower model with connections and that of the single‐tower model. Some engineering countermeasures are put forward to reduce the vertical deformation difference of the twin‐tower connected structure.
Determination of the relative macroporosity and the effective aggregate width for different macropore geometries with disk infiltrometers
Authors: Urbina C. A. Faúndez , van Dam J. C. , van den Berg F. , Ritsema C. J. , Tang D. W. S. 
Published: July 2020

AbstractThe relative macroporosity (wf) and the effective aggregate width (dag) are input parameters for several dual‐permeability models. As wf is geometrically related to dag, any improvement in its determination is directly extended to dag. The wf, as estimated by disk infiltrometers, applies only under the assumption that macropores are cylindrically shaped. We generalize the determination of wf for ring, hexagon, brick, and rectangular slab macropore‐matrix shapes using a transformation factor, ξ, obtained from pore‐scale modeling. The ξ was computed by dividing the relative macroporosity for noncylindrical shapes, wf_nc, over the relative macroporosity for cylindrical shapes, wf_c. The computation of ξ accounts for differences in the macropore area and macropore water flow between noncylindrical and cylindrical shapes. A total of 15 combinations of macropore width and effective aggregate width were used to construct the geometrical figures and compute both wf_nc and wf_c. For the cylindrical, ring, and rectangular slab shapes, the macropore water flow was solved using analytical solutions. For the hexagonal and brick shapes, the macropore water flow was solved numerically using COMSOL Multiphysics. Remarkably, the computed ξ was constant and equal to 1.5 for all four noncylindrical shapes under analysis. We show that the solution is exact for laminar flow under saturated conditions in the macropores with a rigid and wettable matrix. This methodology enables the derivation of a better estimate of wf and dag from disk infiltrometer data that include different macropore geometries. This information is crucial for the setup of dual‐permeability models in risk assessments and detailed studies.
Theta lifts for Lorentzian lattices and coefficients of mock theta functions
Authors: Bruinier Jan Hendrik , Schwagenscheidt Markus 
Published: July 2020

AbstractWe evaluate regularized theta lifts for Lorentzian lattices in three different ways. In particular, we obtain formulas for their values at special points involving coefficients of mock theta functions. By comparing the different evaluations, we derive recurrences for the coefficients of mock theta functions, such as Hurwitz class numbers, Andrews’ spt-function, and Ramanujan’s mock theta functions.
Short-term, but not acute, intake of New Zealand blackcurrant extract improves insulin sensitivity and free-living postprandial glucose excursions in individuals with overweight or obesity
Authors: Nolan A. , Brett R. , Strauss J. A. , Stewart C. E. , Shepherd S. O. 
Published: July 2020

Abstract
Impaired postprandial glucose handling and low-grade systemic inflammation are risk factors for developing insulin resistance in individuals with overweight or obesity. Acute ingestion of anthocyanins improves postprandial glucose responses to a single carbohydrate-rich meal under strictly controlled conditions.

Purpose
Examine whether acute and short-term supplementation with anthocyanin-rich New Zealand blackcurrant (NZBC) extract can improve postprandial glucose responses to mixed-macronutrient meals.

Methods
Twenty-five overweight (BMI > 25 kg m2) sedentary individuals participated in one of the following double-blinded, randomised controlled trials: (1) ingestion of 600 mg NZBC extract or placebo prior to consumption of a high-carbohydrate, high-fat liquid meal (n = 12); (2) 8-days supplementation with NZBC extract (600 mg day−1) or placebo, with insulin sensitivity and markers of inflammation assessed on day-7, and free-living postprandial glucose (continuous glucose monitoring) assessed on day-8 (n = 13).

Results
A single dose of NZBC extract had no effect on 3 h postprandial glucose, insulin or triglyceride responses. However, in response to short-term NZBC extract supplementation insulin sensitivity was improved (+ 22%; P = 0.011), circulating C-reactive protein concentrations decreased (P = 0.008), and free-living postprandial glucose responses to both breakfast and lunch meals were reduced (− 9% and − 8%, respectively; P < 0.05), compared to placebo.

Conclusion
These novel results indicate that repeated intake, rather than a single dose of NZBC extract, is required to induce beneficial effects on insulin sensitivity and postprandial glucose handling in individuals with overweight or obesity. Continuous glucose monitoring enabled an effect of NZBC extract to be observed under free-living conditions and highlights the potential of anthocyanin-rich supplements as a viable strategy to reduce insulin resistance.
Would endoscopic surgery be the gold standard for stapes surgery in the future? A systematic review and meta-analysis
Authors: Fang Lucheng , Xu Jiayuan , Wang Wen , Huang Yideng 
Published: July 2020

Abstract
Objective
This meta-analysis is aimed to review and analyze all available data of intraoperative and postoperative results of endoscopic and microscopic stapes surgery.

Methods
According to the PRISMA statements checklist, this systematic review and meta-analysis were designed. Data were extracted from public databases, such as PubMed, Cochrane, Web of Science, and more. The quality of studies was evaluated using the MINORS scale. Odds ratios (ORs) and 95% CIs were estimated for binary outcome data, while the mean differences and 95% CIs were estimated for continuous data. I2 and χ2 tests were used to quantify statistical heterogeneity. If more than ten studies were included in each analysis, funnel plot would be performed to analysis publication bias.

Results
Twelve studies with 620 patients were included in this meta-analysis. Primary outcomes collected in this meta-analysis included average postoperative auditory gain (APAG), postoperative air–bone gap (ABG), the rate of chorda tympani handling and bone curettage, which all showed a statistically significant difference in favor of endoscopy. While only secondary outcomes about postoperative pain and dysgeusia demonstrated a significantly reduced incidence. Furthermore, there was not any statistically significant difference on postoperative dizziness and average operative time between endoscopy and microscopy.

Conclusion
Although there is a need for high-quality pooled data in the future, a consistently superior effect of the endoscopic group was still shown in terms of total effectiveness, when compared to the microscopic group. We have reasons to support the application of endoscopy in stapes surgery. The future of ESS, we believe, is blazing bright.
Deep brain stimulation reduces (nocturnal) dyskinetic exacerbations in patients with ADCY5 mutation: a case series
Authors: de Almeida Marcelino Ana Luísa , Mainka Tina , Krause Patricia , Poewe Werner , Ganos Christos , Kühn Andrea A. 
Published: July 2020

AbstractMutations in the ADCY5 gene can cause a complex hyperkinetic movement disorder. Episodic exacerbations of dyskinesia are a particularly disturbing symptom as they occur predominantly during night and interrupt sleep. We present the clinical short- and long-term effects of pallidal deep brain stimulation (DBS) in three patients with a confirmed pathogenic ADCY5 mutation. Patients were implanted with bilateral pallidal DBS at the age of 34, 20 and 13 years. Medical records were reviewed for clinical history. Pre- and postoperative video files were assessed using the “Abnormal Involuntary Movement Scale” (AIMS) as well as the motor part of the “Burke Fahn Marsden Dystonia Rating Scale” (BFMDRS). All patients reported subjective general improvement ranging from 40 to 60%, especially the reduction of nocturnal episodic dyskinesias (80–90%). Objective scales revealed only a mild decrease of involuntary movements in all and reduced dystonia in one patient. DBS-induced effects were sustained up to 13 years after implantation. We demonstrate that treatment with pallidal DBS was effective in reducing nocturnal dyskinetic exacerbations in patients with ADCY5-related movement disorder, which was sustained over the long term.
CSF disturbances and other neurosurgical complications after interdisciplinary reconstructions of large combined scalp and skull deficiencies
Authors: Butenschoen Vicki M. , Weitz Jochen , Ritschl Lucas M. , Meyer Bernhard , Krieg Sandro M. 
Published: July 2020

AbstractCombined scalp and skull deficiency due to malignant scalp tumors or sequelae of intracranial surgery present challenging entities for both neurosurgeons and reconstructive treatment. In complex cases, an interdisciplinary approach is needed between neurosurgeons and cranio-maxillofacial surgeons. We present a considerably large series for which we identify typical complications and pitfalls and provide evidence for the importance of an interdisciplinary algorithm for chronic wound healing complications and malignomas of the scalp and skull. We retrospectively reviewed all patients treated by the department of neurosurgery and cranio-maxillofacial surgery at our hospital for complex scalp deficiencies and malignant scalp tumors affecting the skull between 2006 and 2019, and extracted data on demographics, surgical technique, and perioperative complications. Thirty-seven patients were treated. Most cases were operated simultaneously (n: 32) and 6 cases in a staged procedure. Nineteen patients obtained a free flap for scalp reconstruction, 15 were treated with local axial flaps, and 3 patients underwent full thickness skin graft treatment. Complications occurred in 62% of cases, mostly related to cerebrospinal fluid (CSF) circulation disorders. New cerebrospinal fluid (CSF) disturbances occurred in 8 patients undergoing free flaps and shunt dysfunction occurred in 5 patients undergoing local axial flaps. Four patients died shortly after the surgical procedure (perioperative mortality 10.8%). Combined scalp and skull deficiency present a challenging task. An interdisciplinary treatment helps to prevent severe and specialty-specific complications, such as hydrocephalus. We therefore recommend a close neurological observation after reconstructive treatment with focus on symptoms of CSF disturbances.