bluuebunny/crossref_metadata_2025_split huggingface dataset:
The “State of Implementation” Progress Report (SIPREP):A Pilot Demonstration of a Navigation System for Implementation
Authors: Miech Edward J , Larkin Angela , Lowery Julie C , Butler Andrew J , Pettey Kristin M , Rattray Nicholas A , Penney Lauren S , Myers Jennifer , Damush Teresa M 
Published: August 2020

Abstract
Background: Implementation of new clinical programs across diverse facilities in national healthcare systems like the Veterans Health Administration (VHA) can be extraordinarily complex. Implementation is a dynamic process, influenced heavily by local organizational context and the individual staff at each medical center. It is not always clear in the midst of implementation what issues are most important to whom or how to address them. In recognition of these challenges, implementation researchers within VHA developed a new systemic approach to map the implementation work required at different stages and provide ongoing, detailed and nuanced feedback about implementation progress.Methods: This observational pilot demonstration project details how a novel approach to monitoring implementation progress was applied across two different national VHA initiatives. Stage-specific grids organized the implementation work into columns, rows and cells, identifying specific implementation activities at the site level to be completed along with who was responsible for completing each implementation activity. As implementation advanced, item-level checkboxes were crossed off and cells changed colors, offering a visual representation of implementation progress within and across sites across the various stages of implementation. Results: Applied across two different national initiatives, the SIPREP provided a novel navigation system to guide and inform ongoing implementation within and across facilities. The SIPREP addressed different needs of different audiences, both described and explained how to implement the program, made ample use of visualizations, and revealed both what was happening and not happening within and across sites. The final SIPREP product spanned distinct stages of implementation. Conclusions: The SIPREP made the work of implementation explicit at the facility level (i.e., who does what, and when) and provided a new common way for all stakeholders to monitor implementation progress and to help keep implementation moving forward. This approach could be adapted to a wide range of settings and interventions, and is planned to be integrated into the national deployment of two additional VHA initiatives within the next 12 months.
Significant progressive heterobeltiosis in banana crossbreeding
Authors: Batte Michael , Nyine Moses , Uwimana Brigitte , Swennen Rony , Akech Violet , Brown Allan , Hovmalm Helena Persson , Geleta Mulatu , Ortiz Rodomiro 
Published: August 2020

Abstract
Background: Heterobeltiosis is the phenomenon when the hybrid’s performance is superior to its best performing parent. Banana ( Musa spp. AAA) breeding is a tedious, time-consuming process, taking up to two decades to develop a consumer acceptable hybrid. Exploiting heterobeltiosis in banana breeding will help to select breeding material with high complementarity, thus increasing banana breeding efficiency. The aim of this study was therefore to determine and document the level of heterobeltiosis of bunch weight and plant stature in the East African highland bananas, in order to identify potential parents that can be used to produce offspring with desired bunch weight and stature after a few crosses.Results: This research found significant progressive heterobeltiosis in cross-bred ‘Matooke’ (highland cooking) banana hybrids, also known as NARITAs, when grown together across years with their parents and grandparents in Uganda. Most (all except 4) NARITAs exhibited positive heterobeltiosis for bunch weight, whereas slightly more than half of them had negative heterobeltiosis for stature. The secondary triploid NARITA 17 had the highest heterobeltiosis for bunch weight: 249% versus its matooke grandparent and 136% against its primary tetraploid parent. Broad sense heritability (across three cropping cycles) for yield potential and bunch weight were high (0.84 and 0.76 respectively), while that of plant stature was very low (0.0035). There was a positive significant correlation ( P < 0.05) between grandparent heterobeltiosis for bunch weight and genetic distance between parents (r = 0.39, P = 0.036), bunch weight (r = 0.7, P < 0.001), plant stature (r = 0.38, P = 0.033) and yield potential (r = 0.59, P < 0.001). Grandparent heterobeltiosis for plant stature was significantly, but negatively, correlated to the genetic distance between parents (r = -0.6, P < 0.001).Conclusions: Such significant heterobeltiosis exhibited for bunch weight is to our knowledge the largest among main food crops. Since bananas are vegetatively propagated, the effect of heterobeltiosis is easily fixed in the hybrids and will not be lost over time after the release and further commercialization of these hybrids.
RICE CENTRORADIALIS 1, a TFL1-like gene, Responses to Drought Stress and Regulates Rice Flowering Transition
Authors: Wang Yan , Lu Yuyang , Guo Ziyu , Ding Yanfeng , Ding Chengqiang 
Published: August 2020

Abstract
Background: The initiation of flowering transition in rice (Oryza sativa) is a complex process regulated by genes and environment. In particular, drought can interfere with flowering; therefore, many plants hasten this process to shorten their life cycle under water scarcity, and this is known as drought-escape response. However, rice has other strategies; for example, drought stress can delay flowering instead of accelerating it. RICE CENTRORADIALIS 1 (RCN1) is a TERMINAL FLOWER-like gene that influences rice flowering transition and spike differentiation. It interacts with 14-3-3 proteins and transcription factor OsFD1 to form a florigen repression complex that suppresses flowering transition in rice.Results: In this study, we explored the role of RCN1 in the molecular pathway of drought-regulated flowering transition. The rcn1 mutant plants displayed early heading under both normal water and drought stress conditions, and they were more insensitive to drought stress than the wild-type plants. Abscisic acid (ABA) signaling-mediated drought-induced RCN1 is involved in this process.Conclusions: Thus, RCN1 plays an important role in the process of drought stress inhibiting flowering transition. It may worked by suppressing the protein function rather than transcription of HEADING DATE 3a.
Integrated analysis identifies a pathway-related competing endogenous RNA network in the progression of Pancreatic cancer
Authors: Zu Fuqiang , Liu Peng , Wang Huaitao , Zhu Ting , Sun Jian , Sheng Weiwei , Tan Xiaodong 
Published: August 2020

Abstract
Background: It is well acknowledged that cancer-related pathways play pivotal roles in the progression of pancreatic cancer (PC). Employing Integrated analysis, we aim to identify the pathway-related ceRNA network associated with PC progression.Methods: We divided eight GEO datasets into three groups according to their platform, and combined TCGA and GTEx databases as a group. Additionally, we screened out the differentially expressed genes (DEGs) and performed functional enrichment analysis in each group, and recognized the top hub genes in the most enriched pathway. Furthermore, the upstream of miRNAs and lncRNAs were predicted and validated according to their expression and prognostic roles. Finally, the co-expression analysis was applied to identify a pathway-related ceRNA network in the progression of PC.Results: A total of 51 significant pathways that common enriched in all groups were spotted. Enrichment analysis indicated that pathway in cancer was greatly linked with tumor formation and progression. Next, the top 20 hug genes in this pathway were recognized, and stepwise prediction and validation from mRNA to lncRNA, including 11 hub genes, 4 key miRNAs, and 2 key lncRNAs, were applied to identify a meaningful ceRNA network according to ceRNA rules. Ultimately, we identified the PVT1/miR-20b-/CCND1 axis as a promising pathway-related ceRNA axis in the progression of PC.Conclusion: Overall, we elucidate the pathway-related ceRNA regulatory network of PVT1/miR-20b-/CCND1 in the progression of PC, which can be considered as therapeutic targets and encouraging prognostic biomarkers for PC.
Effects of Desflurane and Sevoflurane Anesthesia on Regulatory T Cells in Patients Undergoing Living Donor Kidney Transplantation A Randomized Intervention Trial
Authors: Chutipongtanate Arpa , Prukviwat Sasichol , Pongsakul Nutkridta , Sris Supanart , Kamanee Nakarin , Arpornsujaritkun Nuttapon , Gesprasert Goragoch , Apiwattanakul Nopporn , Hongeng Suradej , Ittichaikulthol Wichai , Sumethkul Vasant , Chutipongtanate Somchai 
Published: August 2020

Abstract
Background: Volatile anesthetic agents used during surgery have immunomodulatory effects which could affect postoperative outcomes. Recognizing that regulatory T cells (Tregs) plays crucial roles in transplant tolerance and high peripheral blood Tregs associated with stable kidney graft function, knowing which volatile anesthetic agents can induce peripheral blood Tregs increment would have clinical implications. This study aimed to compare effects of desflurane and sevoflurane anesthesia on peripheral blood Tregs induction in patients undergoing living donor kidney transplantation.Methods: A prospective, randomized, double-blind trial in living donor kidney transplant recipients was conducted at a single center, tertiary-care, academic university hospital in Thailand during August 2015 – June 2017. Sixty-six patients were assessed for eligibility and 40 patients who fulfilled the study requirement were equally randomized and allocated to desflurane versus sevoflurane anesthesia during transplant surgery. The primary outcome included absolute changes of peripheral blood CD4+CD25+FoxP3+Tregs which measured by flow cytometry and expressed as the percentage of the total population of CD4+ T lymphocytes at pre-exposure (0-h) and post-exposure (2-h and 24-h) to anesthetic gas. P-value <0.05 denoted statistical significance.Results: Demographic data were comparable between groups. No statistical difference of peripheral blood Tregs between desflurane and sevoflurane groups observed at the baseline pre-exposure (3.6±0.4% vs. 3.1±0.4%; p=0.371) and 2-h post-exposure (3.0±0.3% vs. 3.5±0.4%; p=0.319). At 24-h post-exposure, peripheral blood Tregs was significantly higher in desflurane group (5.8±0.5% vs. 4.1±0.3%; p=0.008). Within group analysis showed patients receiving desflurane, but not sevoflurane, had 2.7% increase in peripheral blood Treg over 24-h period (p<0.001). Conclusion: This study provides the clinical trial-based evidence that desflurane induced peripheral blood Tregs increment after 24-h exposure, which could be beneficial in the context of kidney transplantation. Mechanisms of action and clinical advantages of desflurane anesthesia based on Treg immunomodulation should be investigated in the future. Trial registration: ClinicalTrials.gov, NCT02559297. Registered 22 September 2015 - retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT02559297
Research on wireless distributed financial risk data stream mining based on dual privacy protection
Authors: Zhao Yuhao 
Published: August 2020

Abstract
With the advancement of network technology and large-scale computing, distributed data streams have been widely used in the application of financial risk analysis. However, while data mining reveals financial models, it also increasingly poses a threat to privacy. Therefore, how to prevent privacy leakage during the efficient mining process poses new challenges to the data mining technology. This article is mainly aimed at the current privacy data leakage in financial data mining, combined with existing data mining technology to study data mining and privacy protection. First, a data mining model for dual privacy protection is defined, which can better meet the characteristics of distributed data streams while achieving privacy protection effects. Secondly, a privacy-oriented data stream mining algorithm is proposed, which uses random interference technology to effectively protect the original sensitive data. Finally, the analysis and discussion of the algorithm in this paper through simulation experiments show that the algorithm is feasible and effective, and can better adapt to the distributed data flow distribution and dynamic characteristics, while achieving better privacy protection effects, effectively Reduced communication load.
Recurrent Uterine Tumors Resembling Ovarian Sex-cord Tumors with the Growth Regulation by Estrogen in Breast Cancer 1-Nuclear Receptor Coactivator 2 Fusion Gene: A Case Report and Literature Review
Authors: Chang Bin , Bai Qianming , Liang Lin , Ge Huijuan , Yao Qianlan 
Published: August 2020

Abstract
Background: Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare mesenchymal neoplasms predominantly arising in perimenopausal and postmenopausal women. UTROSCTs with growth regulation by estrogen in breast cancer 1 (GREB1)-rearrangement or GREB1-rearranged uterine tumors are exceptionally rare, with only 12 previously reported cases. Here, we report a case of UTROSCT with the GREB1-nuclear receptor coactivator 2 (NCOA2) fusion gene. Case Presentation: A 57-year-old woman presented with a 10.0 cm uterine mass. The tumor was composed of short spindle or epithelioid cells, arranged in diffused sheets, nested, and trabecular/cordlike. The tumor harbored the GREB1-NCOA2 fusion gene, as confirmed by RNA sequencing. The tumor recurred in the pelvis at 30 months after the initial diagnosis. We also compared the clinical and pathologic features of this case with those of the 12 previously published uterine GREB1-rearranged tumors. Of the combined 13 cases (present case and 12 previous cases), the mean age of patients was 64.8 years (range, 51‒74 years). Of the nine reported cases of GREB1-rearranged tumor with follow up, four cases recurred or metastasized (44.4%). Microscopically, most tumors (10/12, 83.3%) showed infiltrative growth, and two were well demarcated. Mitotic figures ranged from 0 to 14 per 10 high-power fields (2 mm2; mean: 3.6). Lymphovascular invasion and necrosis were each present in two cases (2/12, 16.7% and 2/7, 28.6%, respectively). Conclusions: This case provided further evidence that UTROSCTs with GREB1-rearrangement may have a high risk of recurrence/metastasis. Further studies are necessary to clarify the clinical features of this type of tumor, particularly the prognosis, potential treatment, and range of possible molecular events.
Carpal Tunnel Syndrome After Recurrent Pregnancies
Authors: Kisli Mesude 
Published: August 2020

Abstract
Background The primary aim of the retrospective study was to study whether the number of births in women (primipara, multipara and grand multipara women) the long term after deliveries has an impact on the development of Carpal tunnel syndrome (CTS). Methods Our study population is composed of patients who are referred with suspicion of CTS. Four hundred and fifty female patients (150 primara, 150 multipara and 150 grand multipara women) referred to the electrophsiology laboratory with clinical suspicion CTS were included into the descriptive and retrospective study between November 2016 and June 2018. Primiparity, multiparity and grand multiparity were defined as women having 1, 2 – 5 and 6 - 9 deliveries, respectively. Patients who passed 2 years after their last birth were included in the study. All of the patients were assessed and compared in terms of electrophysiological CTS presence and degree of CTS. Also BMI was calculated for each patient and it compared among groups. Results The disease has not been changed with the number of births (p > 0.05). The mean BMI of the primipara, multipara and grand multipara women were 28,06 ± 1,12 kg / m2, 27,59 ± 3,72 kg / m2 and 27,82 ± 3,11 kg / m2, respectively. There was no significant statistically difference in BMI among groups (p > 0.05). However, the severity of the disease varies according to BMI (p < 0.05). It was calculated that as the BMI increases, the severity of the disease increases. Conclusions Number of pregnancies in women (primipara, multipara and grand multipara women) concerning the long term after deliveries has not impact on the development of CTS. Other risk factors such as BMI may play a significant role in the development of CTS in these patients.
Genome-Wide Identification and Functional Characterization of the PheE2F/DP Gene Family in Moso Bamboo
Authors: Li Long , Shi Qianqian , Gao Jian 
Published: August 2020

Abstract
BackgroundE2F/DP proteins have been shown to regulate genes implicated in cell cycle control and DNA repair. However, to date, research into the potential role of Moso bamboo E2F/DP family has been limited.ResultsHere, we identified 24 E2F/DPs in the Moso bamboo genome including nine E2F, six DP, eight DEL and one gene with partial E2F domain. Estimation of the divergence time of paralogous gene pairs suggested that E2F/DP family expansion was mainly contributed by whole-genome duplication event. The regulatory element and coexpression network analysis indicated that E2F/DP regulated the expression of cell cycle-related genes. Yeast two hybrid assay and expression analysis based on transcriptome data and in situ hybridization indicated that PheE2F-PheDP complex played important roles in winter moso bamboo shoot growth. qRT-PCR results showed that PheE2F/DPs performed diverse expression patterns in response to drought and salt treatment and diurnal cycles. ConclusionOur findings provide novel insights into the Moso bamboo E2F/DP family and partial experimental evidence for further functional verification of the PheE2F/DPs.
Clinical Characteristics and Prognosis of Adult Orbital Cellulitis in a Tertiary General Hospital
Authors: Yao Bangtao , Ding Yuhua , Zhao Xiaogui , Wang Bei , Liu Gang , Wang Fei 
Published: August 2020

Abstract
Background: Adult orbital cellulitis (OC) occurs relatively rarely, and comprehensive studies that retrospectively evaluate OC are lacking. Here we aimed to examine the clinical characteristics and prognosis of OC in a tertiary general hospital. Methods: Between October 2010 and May 2019, patients presenting with clinical symptoms of OC in a tertiary general hospital were analyzed in this retrospective study. Twenty-six cases were identified for a detailed review. In these cases, 16 males and 10 females were diagnosed with orbital cellulitis by clinical characteristics and multimodal examinations. We divided patients into three groups: (1) patients secondary to rhinosinusitis, (2) patients secondary to endogenous infection(s) without endophthalmitis, and (3) patients secondary to endophthalmitis. For each group, the age, gender, eye type, combined systemic diseases, clinical presentation, leukocyte count, blood culture, diagnostic imaging, therapeutic methods, length of stay, time of post-operation, and patient prognosis were analyzed in detail. Results: There were no significant differences regarding age, gender, preoperative leukocyte count, exophthalmia, blood culture, treatment, or visual changes within the three groups (P>0.05). There were significant differences, however, in postoperative leukocyte count and ophthalmoplegia between the three groups (P<0.05). The preoperative and postoperative logarithm of the minimum resolution angle scored by the best-corrected visual acuity (LogMAR BCVA) of group 3 were statistically significant compared to group 1 and group 2 (P<0.05). Conclusion: We confirmed that the prognosis of OC patients combined with systemic diseases was poor; the visual outcome of OC secondary to endophthalmitis was more serious than that, secondary to sinusitis or endogenous infection without endophthalmitis. The level of leukocytes may indicate the condition of the disease.
On the Rivers in the Euro-Atlantic Sky
Authors: Thandlam Venugopal , Rutgersson Anna , Sahlee Erik 
Published: August 2020

Abstract
We study and revisit the Atmospheric Rivers (AR) over Euro-Atlantic sky using long term reanalysis datasets and widely used methods and parameters. The atmospheric winds, temperature and specific humidity at different pressure levels during 1979-2018 were used to study the spatiotemporal variability of water vapour transport integrated between 1000-300 hPa (IVT300) as a proxy to ARs. The standard deviation (200 kgm-1s-1) of ARs is around 60% of the climatology (>300 kgm-1s-1) in all reanalysis datasets in the North Atlantic. High frequency of ARs over western Europe in winter half-year (WHY) has 6% lower intensity compared to the low frequency of ARs in summer half-year (SHY) with 3% higher intensity than the annual mean. The intensity of ARs in the North Atlantic has been increasing in recent times with large decadal variability and poleward shift in landfalling. The magnitude of atmospheric parameters in the lower atmosphere below 750 hPa dominates the total column water vapour and intensity of ARs. There is a significant impact of the North Atlantic Oscillation and Scandinavian blocking on the location of landfalling of ARs and latitudinal dependence of the source of moisture flux in the open ocean contributing to the formation and enhancing ARs strength.
Mitochondrial Defects in the Respiratory Complex I Contribute to Impaired Translational Initiation via ROS and Energy Homeostasis in SMA Motor Neurons
Authors: Thelen Maximilian Paul , Wirth Brunhilde , Kye Min Jeong 
Published: August 2020

Abstract
BackgroundSpinal muscular atrophy (SMA) is a neuromuscular disease, characterized by loss of lower alpha motor neurons, which leads to proximal muscle weakness. SMA is caused by reduced levels of Survival of Motor Neuron (SMN) due to biallelic deletions or mutations in the SMN1 gene and mainly non-functional SMN2 copy gene. When SMN levels fall under a certain threshold, a plethora of cellular pathways are disturbed including RNA processing, protein synthesis, metabolic defects and dysfunctional mitochondria. Dysfunctional mitochondria can harm cells by decreased ATP production, but also by increased oxidative stress due to elevated production of reactive oxygen species (ROS). Since neurons mainly produce energy via mitochondrial oxidative phosphorylation to cover their high energy demands, restoring metabolic/ oxidative homeostasis can be beneficial in SMA pathology.MethodsWe performed whole proteome analysis of murine primary motor neurons using mass spectrometry to identify molecular mechanisms altered by SMN deficiency, which contribute to SMA pathology. Identified pathways were independently confirmed by biochemical and molecular biological methods as well as imaging analysis. Furthermore, cellular energy and ROS levels were biochemically measured in WT and SMA motor neurons.ResultsWe report that primary SMA motor neurons show disturbed energy homeostasis such as a reduced number of functional mitochondria, impaired glucose uptake and overall lower basal ATP concentrations. In addition, elevated ROS levels cause an increase of protein carbonylation and impaired protein synthesis efficiency in SMA motor neurons. Counteracting these cellular impairments with supplemented pyruvate reduced elevated ROS levels, increased ATP and SMN protein levels in SMA motor neurons. Furthermore, we found that pyruvate-mediated SMN protein synthesis is mTOR-dependent. Most importantly, we show that ROS regulates global protein synthesis at the translational initiation step, which is impaired in SMA.ConclusionIn summary, we found that excessive amount of cellular ROS caused by defective mitochondria inhibits initiation of mRNA translation, which results in pathological phenotypes often observed in degenerative neurons. As many neuropathies share patho-phenotypes such as dysfunctional mitochondria, excessive ROS and impaired protein synthesis.Our findings suggest a new molecular networking system among these pathways.