bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defense against predators incurs high reproductive costs for the aposematic moth Arctia plantaginis
Authors: Lindstedt Carita , Suisto Kaisa , Burdfield-Steel Emily , Winters Anne E , Mappes Johanna 
Published: April 2020

Abstract
To understand how variation in warning displays evolves and is maintained, we need to understand not only how perceivers of these traits select color and toxicity but also the sources of the genetic and phenotypic variation exposed to selection by them. We studied these aspects in the wood tiger moth Arctia plantaginis, which has two locally co-occurring male color morphs in Europe: yellow and white. When threatened, both morphs produce defensive secretions from their abdomen and from thoracic glands. Abdominal fluid has shown to be more important against invertebrate predators than avian predators, and the defensive secretion of the yellow morph is more effective against ants. Here, we focused on the morph-linked reproductive costs of secretion of the abdominal fluid and quantified the proportion of phenotypic and genetic variation in it. We hypothesized that, if yellow males pay higher reproductive costs for their more effective aposematic display, the subsequent higher mating success of white males could offer one explanation for the maintenance of the polymorphism. We first found that the heritable variation in the quantity of abdominal secretion was very low (h2 = 0.006) and the quantity of defensive secretion was not dependent on the male morph. Second, deploying the abdominal defensive secretion decreased the reproductive output of both color morphs equally. This suggests that potential costs of pigment production and chemical defense against invertebrates are not linked in A. plantaginis. Furthermore, our results indicate that environmentally induced variation in chemical defense can alter an individual’s fitness significantly.
Blood-based multi-tissue gene expression inference with Bayesian ridge regression
Authors: Xu Wenjian , Liu Xuanshi , Leng Fei , Li Wei 
Published: April 2020

Abstract

Motivation
Gene expression profiling is widely used in basic and cancer research but still not feasible in many clinical applications because tissues, such as brain samples, are difficult and not ethnical to collect. Gene expression in uncollected tissues can be computationally inferred using genotype and expression quantitative trait loci. No methods can infer unmeasured gene expression of multiple tissues with single tissue gene expression profile as input.

Results
Here, we present a Bayesian ridge regression-based method (B-GEX) to infer gene expression profiles of multiple tissues from blood gene expression profile. For each gene in a tissue, a low-dimensional feature vector was extracted from whole blood gene expression profile by feature selection. We used GTEx RNAseq data of 16 tissues to train inference models to capture the cross-tissue expression correlations between each target gene in a tissue and its preselected feature genes in peripheral blood. We compared B-GEX with least square regression, LASSO regression and ridge regression. B-GEX outperforms the other three models in most tissues in terms of mean absolute error, Pearson correlation coefficient and root-mean-squared error. Moreover, B-GEX infers expression level of tissue-specific genes as well as those of non-tissue-specific genes in all tissues. Unlike previous methods, which require genomic features or gene expression profiles of multiple tissues, our model only requires whole blood expression profile as input. B-GEX helps gain insights into gene expressions of uncollected tissues from more accessible data of blood.

Availability and implementation
B-GEX is available at https://github.com/xuwenjian85/B-GEX.

Supplementary information
Supplementary data are available at Bioinformatics online.
BAI1 acts as a tumor suppressor in lung cancer A549 cells by inducing metabolic reprogramming via the SCD1/HMGCR module
Authors: Liu Lei , Chai Li , Ran Jingjing , Yang Ying , Zhang Li 
Published: April 2020

Abstract
Brain-specific angiogenesis inhibitor 1 (BAI1) is an important tumor suppressor in multiple cancers. However, the mechanisms behind its anti-tumor activity, particularly the relationship between BAI1 and metabolic aberrant of a tumor, remained unveiled. This study aimed to investigate whether BAI1 could inhibit biological functions in lung cancer A549 cells and the critical regulating molecules that induce metabolic reprogramming. Immunohistochemistry staining was performed to analyze whether variations in the expression of BAI1 in tumor tissues contributes to poor prognosis of lung cancer. Overexpressed BAI1 (BAI1-OE-A549) and control (Vector-NC-A549) were generated by lentiviral transfection. Biological function assays (proliferation, apoptosis, colony formation, invasion and in vivo metastasis), as well as metabolic reprogramming (by the Warburg effect and the glycolytic rate), were performed in both groups. Our results indicated that lower levels of BAI1 contributed to poor prognosis of lung cancer patients. Furthermore, overexpressed of BAI1 dramatically inhibited proliferation, migration, invasion, colony formation and in vivo metastasis of A549 cells. The Warburg effect and the Seahorse assay revealed that BAI1-OE induced metabolism reprogramming by inhibiting the Warburg effect and glycolysis. Further exploration indicated that BAI1 induced metabolic reprogramming by upregulating stearoyl-CoA desaturase 1 (SCD1) and inhibited 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Our study revealed a novel mechanism through which BAI1 acted as tumor suppressor by inducing metabolic reprogramming via the SCD1 and HMGCR module.
The Impact of Different Types of Violence on Ebola Virus Transmission During the 2018–2020 Outbreak in the Democratic Republic of the Congo
Authors: Kelly John Daniel , Wannier Sarah Rae , Sinai Cyrus , Moe Caitlin A , Hoff Nicole A , Blumberg Seth , Selo Bernice , Mossoko Mathais , Chowell-Puente Gerardo , Jones James Holland , Okitolonda-Wemakoy Emile , Rutherford George W , Lietman Thomas M , Muyembe-Tamfum Jean Jacques , Rimoin Anne W , Porco Travis C , Richardson Eugene T 
Published: April 2020

Abstract

Background
Our understanding of the different effects of targeted versus nontargeted violence on Ebola virus (EBOV) transmission in Democratic Republic of the Congo (DRC) is limited.

Methods
We used time-series data of case counts to compare individuals in Ebola-affected health zones in DRC, April 2018–August 2019. Exposure was number of violent events per health zone, categorized into Ebola-targeted or Ebola-untargeted, and into civilian-induced, (para)military/political, or protests. Outcome was estimated daily reproduction number (Rt) by health zone. We fit linear time-series regression to model the relationship.

Results
Average Rt was 1.06 (95% confidence interval [CI], 1.02–1.11). A mean of 2.92 violent events resulted in cumulative absolute increase in Rt of 0.10 (95% CI, .05–.15). More violent events increased EBOV transmission (P = .03). Considering violent events in the 95th percentile over a 21-day interval and its relative impact on Rt, Ebola-targeted events corresponded to Rt of 1.52 (95% CI, 1.30–1.74), while civilian-induced events corresponded to Rt of 1.43 (95% CI, 1.21–1.35). Untargeted events corresponded to Rt of 1.18 (95% CI, 1.02–1.35); among these, militia/political or ville morte events increased transmission.

Conclusions
Ebola-targeted violence, primarily driven by civilian-induced events, had the largest impact on EBOV transmission.
This IsThe ShackThat Job Built: Theodicy and Polytheism in William Paul Young’s Evangelical Bestseller
Authors: Douglas Christopher 
Published: April 2020

AbstractWilliam Paul Young’s bestselling evangelical novel The Shack (2007) is a twenty-first century re-imagining of the Biblical book of Job, a re-imagining that strangely multiplies the number of divine beings responding to the problem of suffering. I argue that Young has inadvertently rediscovered the ancient Israelite polytheism of three thousand years ago, for the simple reason that justifying the gods’ ways to humans is an easier task than justifying God’s ways to humans. A “deep time” approach to contemporary religiously-interested literature illuminates the Biblical and Ancient Near East texts with which The Shack is in dialogue. Recent critical-historical Bible scholarship, meanwhile, uncovers the pantheon of gods worshipped in ancient Israelite religion, gods whose genealogical traces lead us to The Shack’s divine characters.
Nurse workarounds in the electronic health record: An integrative review
Authors: Fraczkowski Dan , Matson Jeffrey , Lopez Karen Dunn 
Published: April 2020

AbstractObjectiveThe study sought to synthesize published literature on direct care nurses’ use of workarounds related to the electronic health record.Materials and MethodsWe conducted an integrative review of qualitative and quantitative peer-reviewed research through a structured search of Academic Search Complete, EBSCO Cumulative Index of Nursing and Allied Health Literature (CINAHL), Embase, Engineering Village, Ovid Medline, Scopus, and Web of Science. We systematically applied exclusion rules at the title, abstract, and full article stages and extracted and synthesized their research methods, workaround classifications, and probable causes from articles meeting inclusion criteria.ResultsOur search yielded 5221 results. After removing duplicates and applying rules, 33 results met inclusion criteria. A total of 22 articles used qualitative approaches, 10 used mixed methods, and 1 used quantitative methods. While researchers may classify workarounds differently, they generally fit 1 of 3 broad categories: omission of process steps, steps performed out of sequence, and unauthorized process steps. Each study identified probable causes, which included technology, task, organizational, patient, environmental, and usability factors.ConclusionsExtensive study of nurse workarounds in acute settings highlights the gap in ambulatory care research. Despite decades of electronic health record development, poor usability remains a key concern for nurses and other members of care team. The widespread use of workarounds by the largest group of healthcare providers subverts quality health care at every level of the healthcare system. Research is needed to explore the gaps in our understanding of and identify strategies to reduce workaround behaviors.
Alleged predisposing dietary factors fail to increase the incidence of osteochondrosis-like lesions in growing pigs at 14 and 24 wk of age
Authors: Grez-Capdeville Mariola , Gross Nicole , Baker Joni C , Shutter Jennifer A , Haas Amanda R , Wilson Mark E , Crenshaw Thomas D 
Published: April 2020

AbstractEarly lesions of osteochondrosis (OC) are exhibited by regions of cartilage retention along the growth plate and articular cartilage. Progression of OC lesions may impair locomotion and necessitate euthanasia in adherence to animal welfare guides. Little is known about the role of nutrition in the initiation and early stages of OC. However, dietary components are commonly implicated as predisposing factors. In this study, diets were altered as an attempt to induce early stage OC lesions under controlled conditions. At 8 wk of age, 96 crossbred gilts (body weight [BW] = 17.4 ± 0.18 kg) were randomly assigned to one of four corn-soybean meal-based diets (four pens per diet, six pigs per pen) to assess diet effects on the number and volume of OC lesions in the distal femur. Diets included a non-pelleted control diet (Ctl); Ctl plus 20% glucose (Glc); the Ctl with increased concentrations of lysine, Ca, and P (+CaP); and the +CaP diet in a pelleted form (PEL). Femurs were collected from pigs euthanized at either 14-wk (Wk 14) or 24-wk (Wk 14) of age for assessments of OC lesions. Based on a mixed model analysis with pen as the experimental unit, dietary treatments did not affect final BW (129.3 ± 3.8 kg) or average daily gain (ADG) (1.00 ± 0.03 kg/d) over the trial. As expected, pigs fed PEL and Glc diets were more efficient (P &lt; 0.05) in feed conversion compared with Ctl and +CaP. Using femurs as the experimental unit at Wk 14 (collected from two of the six pigs per pen), bone mineral content, determined by dual-energy x-ray absorptiometry scans, was greater (P &lt; 0.05) in pigs fed +CaP and PEL than Ctl or Glc diets; however, only +CaP group differed (P &lt; 0.05) at Wk 24 (collected from four pigs per pen). Computed tomography (CT) scans of femurs were reconstructed as three-dimensional images to allow detection of the number, volume, and surface area of lesions in distal growth plates. At Wk 14, pigs fed Ctl had fewer number of lesions (P &lt; 0.05); however, no differences were detected among dietary treatments in lesion volume or lesion surface area. Pigs had fewer lesions at Wk 24 than Wk 14; however, differences were not detected among dietary treatments. At Wk 24, pigs fed Ctl diets had the greatest lesion volume among dietary treatments (P &lt; 0.05). In conclusion, none of the pigs exhibited symptoms of lameness regardless of dietary treatment or OC lesion traits. Diet modifications due to pelleting or inclusion of rapidly digestible ingredients, such as glucose, did not increase prevalence or size of OC lesions. Image analysis of CT scans was a reliable method to quantify the number, size, and location of OC lesions.
Effects of increased lysine and energy feeding duration prior to parturition on sow and litter performance, piglet survival, and colostrum quality
Authors: Gourley Kiah M , Swanson Analicia J , DeRouchey Joel M , Tokach Mike D , Dritz Steve S , Goodband Robert D , Woodworth Jason C 
Published: April 2020

AbstractA total of 467 sows were used to evaluate the effect of feeding duration of increased lysine (Lys) and metabolizable energy (ME) prior to farrowing on sow and litter performance, piglet survival, and colostrum quality. Sows were blocked by body weight (BW) and parity category on day 106 of gestation and allotted to one of three dietary regimens starting on day 107 of gestation: 1) Control: 2.0 kg/d gestation feed (12.5 g standardized ileal digestible [SID] Lys and 6.5 Mcal ME) until day 113 of gestation, then 2.7 kg/d lactation feed (28 g SID Lys and 9.4 Mcal ME) until parturition; 2) 2.0 kg/d gestation feed (12.5 g SID Lys and 6.5 Mcal ME) until day 113 of gestation, then 3.8 kg/d lactation feed (40 g SID Lys and 13.3 Mcal ME) until parturition; or 3) 3.8 kg/d lactation feed (40 g SID Lys and 13.3 Mcal ME) until parturition. Data were analyzed for treatment within parity effects using the GLIMMIX procedure of SAS. Increasing the duration of feeding additional Lys and ME increased (P &lt; 0.05) sow weight gain from day 106 to 113. Sow backfat gain from day 106 to 113 of gestation increased (P &lt; 0.05) in gilts and sows fed 3.8 kg/d of the lactation diet starting on day 107 vs. the control regimen. Average total born and born alive piglet birth weight (BiWt) were greater (P &lt; 0.05) in gilts fed 3.8 kg/d lactation diet starting on day 107 or 113 vs. control, with no evidence (P &gt; 0.05) for the difference in piglet BiWt in sows or weaning weight in gilts and sows. Piglet mortality after cross-fostering to weaning was decreased (P &lt; 0.05) in sows fed 3.8 kg/d lactation diet starting on day 113 vs. control or increased lactation diet starting on day 107 but not in gilts. Litter gain from cross-foster to weaning was decreased (P &lt; 0.05) in gilts fed 3.8 kg/d lactation diet starting on day 107 compared with control, with no evidence for difference in sows. Colostrum immunoglobulin G was increased (P &lt; 0.05) in gilts and sows fed 3.8 kg/d of the lactation diet starting on day 113 compared with control. There was no evidence that dietary regimen influenced (P &gt; 0.05) piglet colostrum intake or colostrum yield. There was also no evidence for difference (P &gt; 0.05) among regimens in wean-to-estrus interval, subsequent farrowing rate, or subsequent litter characteristics. In conclusion, feeding increased Lys and ME prior to farrowing increased BW and backfat. Feeding increased Lys and ME when gilts were moved into the farrowing room increased BiWt, but reduced litter growth to weaning, with little evidence that sow performance was influenced in this study.
The Affordable Care Act’s Medicaid Expansion and Impact Along the Cancer-Care Continuum: A Systematic Review
Authors: Moss Haley A , Wu Jenny , Kaplan Samantha J , Zafar S Yousuf 
Published: April 2020

Abstract

Background
Health reform and the merits of Medicaid expansion remain at the top of the legislative agenda, with growing evidence suggesting an impact on cancer care and outcomes. A systematic review was undertaken to assess the association between Medicaid expansion and the goals of the Patient Protection and Affordable Care Act in the context of cancer care. The purpose of this article is to summarize the currently published literature and to determine the effects of Medicaid expansion on outcomes during points along the cancer care continuum.

Methods
A systematic search for relevant studies was performed in the PubMed/MEDLINE, EMBASE, Scopus, and Cochrane databases. Three independent observers used an abstraction form to code outcomes and perform a quality and risk of bias assessment using predefined criteria.

Results
A total of 48 studies were identified. The most common outcomes assessed were the impact of Medicaid expansion on insurance coverage (23.4% of studies), followed by evaluation of racial and/or socioeconomic disparities (17.4%) and access to screening (14.5%). Medicaid expansion was associated with increases in coverage for cancer patients and survivors as well as reduced racial- and income-related disparities.

Conclusions
Medicaid expansion has led to improved access to insurance coverage among cancer patients and survivors, particularly among low-income and minority populations. This review highlights important gaps in the existing oncology literature, including a lack of studies evaluating changes in treatment and access to end-of-life care following implementation of expansion.
Unusual pulmonary vein variant in a patient with right upper lobe lung cancer
Authors: Tobita Rika , Nakamura Ryota , Inage Yoshihisa 
Published: April 2020

Abstract
It is essential to understand individual pulmonary anatomy, and the relationship between the tumor and surrounding organ, when lung resection is conducted. Recently, many anomalous pulmonary venous variations have been detected using three-dimensional computed tomography (3D-CT). Herein, we report the case of a 62-year-old women with lung cancer and an anomalous right upper lobe pulmonary vein that drained into the left atrium between the pulmonary artery and bronchus. Preoperative 3D-CT clearly demonstrated the anomalous pulmonary vein, and we safely performed lung resection by thoracoscopic surgery. Therefore, 3D-CT images can help ensure the safety of patients with aberrant vasculature during lung resection.
Dynamical friction-driven orbital circularization in rotating discs: a semi-analytical description
Authors: Bonetti Matteo , Bortolas Elisa , Lupi Alessandro , Dotti Massimo , Raimundo Sandra I 
Published: April 2020

ABSTRACT
We present and validate a novel semi-analytical approach to study the effect of dynamical friction (DF) on the orbits of massive perturbers in rotating stellar discs. We find that DF efficiently circularizes the orbit of co-rotating perturbers, while it constantly increases the eccentricity of counter-rotating ones until their angular momenta reverse, then once again promoting circularization. Such ‘drag toward circular co-rotation’ could shape the distribution of orientations of kinematically decoupled cores in disc galaxies, naturally leading to the observed larger fraction of co-rotating cores.
Latent Trajectories and Profiles of Commercial Cigarette Smoking Frequency From Adolescence to Young Adulthood Among North American Indigenous People
Authors: Hautala Dane , Sittner Kelley , Walls Melissa 
Published: April 2020

AbstractIntroductionNorth American Indigenous people (ie, American Indian/Alaska Native and Canadian First Nations) have the highest rates of commercial cigarette smoking, yet little is known about long-term trajectories of use among this population. The purpose of this study is to examine heterogeneous trajectories and profiles of Indigenous cigarette use frequency from early adolescence (mean age: 11.1 years) to young adulthood (mean age: 26.3 years).Aims and MethodsData come from a nine-wave prospective longitudinal study spanning early adolescence through young adulthood among Indigenous people in the Upper Midwest of the United States and Canada (N = 706). Smoking frequency was examined at each wave, and latent class growth analysis was used to examine heterogeneous patterns. Early adolescent and young adult demographics and smoking-related characteristics were examined across these latent trajectory groups.ResultsIn young adulthood, 52% of participants smoked daily/near-daily, and an additional 10% smoked weekly or monthly. Four latent trajectory groups emerged: low/non-smokers (35.2%) who had low probabilities of smoking across the study; occasional smokers (17.2%) who had moderate probabilities of smoking throughout adolescence and declining probabilities of smoking into young adulthood; mid-adolescent onset smokers (21.6%) who showed patterns of smoking onset around mid-adolescence and escalated to daily use in young adulthood; and early-adolescent onset smokers (25.9%) who showed patterns of onset in early adolescence and escalated to stable daily use by late adolescence.ConclusionsThe findings suggest multiple critical periods of smoking risk, as well as a general profile of diverse smoking frequency patterns, which can inform targeted intervention and treatment programming.ImplicationsNearly two-thirds (62%) of this sample of Indigenous people were current smokers by early adulthood (mean age = 26.3 years), which is substantially higher than national rates in the United States and Canada. Moreover, in all but one trajectory group, smoking prevalence consistently increased over time, suggesting these rates may continue to rise into adulthood. The longitudinal mixture modeling approach used in this study shows that smoking patterns are heterogeneous, and implications for public health policy likely vary across these diverse patterns characterized by timing of onset of use, escalation in frequency of use, and stability/change over time.
Chronic Pulmonary Histoplasmosis—A Scoping Literature Review
Authors: Baker Jacob , Kosmidis Chris , Rozaliyani Anna , Wahyuningsih Retno , Denning David W 
Published: April 2020

Abstract
Chronic pulmonary histoplasmosis (CPH) is an uncommon manifestation of Histoplasma infection with features similar to pulmonary tuberculosis (TB). In endemic areas, it may be misdiagnosed as smear-negative pulmonary TB. Historical case series mainly from patients with presumed TB described a high frequency of cavitation and poor prognosis, likely resulting from delayed presentation. More recent reports suggest that CPH can present with nodules, lymphadenopathy, or infiltrates, with cavities being a less common feature. Emphysema is the main risk factor for cavitary CPH. CPH is therefore an umbrella term, with chronic cavitary pulmonary histoplasmosis and Histoplasma nodules being the main long-term manifestations in nonimmunocompromised individuals. Diagnosis relies on a high index of suspicion, use of fungal culture of respiratory samples, antibody testing, and compatible radiological picture. Treatment with itraconazole for at least 12 months is recommended. Morbidity from CPH results from slow progression of cavities and gradual loss of lung function, especially if not recognized and treated. Studies on the epidemiology of CPH are needed in order to improve understanding of the disease.