bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loneliness, eating, and body mass index in parent–adolescent dyads from the Family Life, Activity, Sun, Health, and Eating study
Authors: Mason Tyler B. 
Published: June 2020

AbstractLoneliness is a salient risk factor for obesity, emotional eating, and poor diet. Because adolescents and parents are embedded within a family unit, their experiences of loneliness may be associated with both their own and one another's behaviors. To examine the extent to which parent and child loneliness predict body mass index (BMI) and eating in parents and adolescents, an actor–partner interdependence model of loneliness, eating, and BMI in adolescent–parent dyads was analyzed. There were actor effects among adolescents such that greater loneliness was positively associated with emotional eating and BMI‐z, and there was an actor effect among parents such that higher loneliness was positively related to emotional eating. There was a partner effect among adolescents such that greater parental loneliness was positively associated with adolescent emotional eating, and there was a partner effect among parents such that higher adolescent loneliness was positively associated with parental emotional eating. There were several actor–partner effects for loneliness and junk food in dyads with boys. Findings highlight the importance of dyadic models of loneliness in adolescent–parent dyads.
The effect of the disaster management training program among nursing students
Authors: Koca Bennur , Arkan Gulcihan 
Published: June 2020

AbstractObjectiveThis study investigated the effect of the Jennings Disaster Nursing Management Model‐based and learning management system‐assisted six‐module training programme on nursing students’ disaster preparedness perceptions and response self‐efficacy.Design and sampleThis randomized controlled trial used a two group comparison design, experimental group (n = 127), and control group (n = 108), carried out with third‐year nursing students in a city in the west of Turkey.MeasuresData included a socio‐demographic form, the Disaster Preparedness Perception Scale in Nurses (DPPSN) and the Disaster Response Self‐Efficacy Scale (DRSES).ResultsAfter the training, disaster preparedness perceptions and the response self‐efficacy of the EG increased significantly (p < .05). This study had a moderate effect on participants’ knowledge and self‐efficacy.ConclusionPublic health nurses are health professionals with important roles and responsibilities in the stages of disaster preparedness, response, and recovery that is all stages of disaster management. This theoretical‐based program can be considered for both students and nursing professionals.
Hypericin Accumulation as a Determinant of PDT Efficacy
Authors: Kessel David 
Published: June 2020

AbstractEfficacy of photodynamic therapy (PDT) with hypericin was compared using two cell lines in monolayer culture. Photokilling was substantially impaired in the A549 (human‐derived lung tumor) when compared with the 1c1c7 murine hepatoma. The efficacy of PDT with regard to photokilling was correlated with the steady‐state intracellular hypericin concentration. There was otherwise no difference in subcellular targets or the pathway to cell death: paraptosis. In a prior study involving cell lines derived from patients with head and neck cancer, differences in response to PDT had shown no correlation with photosensitizer uptake.
The Common Agricultural Policy beyond 2020: A critical review in light of global environmental goals
Authors: Heyl Katharine , Döring Tobias , Garske Beatrice , Stubenrauch Jessica , Ekardt Felix 
Published: June 2020

AbstractThe Common Agricultural Policy (CAP) is currently undergoing a reform process which is embedded in a political context that is required to effectively and urgently respond to climate change and biodiversity loss. The CAP beyond 2020 has to be in line with the international goals of the Paris Agreement and the Convention on Biological Diversity and at the same time foster mitigation strategies for increasingly challenging natural conditions to secure food security in the long term. Yet, despite the fact that the above‐mentioned objectives call for a complete reorientation of the subsidy scheme, this article shows that the reform proposal does not provide the instruments needed to adequately address these objectives, although a few promising approaches (e.g. ‘eco‐schemes’) have been put on the reform agenda.
Gender‐related differences in the facial aging of Chinese subjects and their relations with perceived ages
Authors: Flament Frederic , Abric Aurelie , Amar David 
Published: June 2020

AbstractObjectiveTo describe the progressing severity of facial signs and their links with perceived age, of Chinese men and women.MethodsFull‐face photographs of 438 Chinese subjects (220 men, 218 women) differently aged (18‐80 years) were taken. These photographs afforded a zoom on 5 facial signs of aging: forehead and crow's feet wrinkles, nasolabial fold, marionette lines and ptosis of the lower face. A panel of 15 experts graded each sign, using the Asian skin aging atlas reference. A naïve panel of 80 Chinese women (20‐60 years) was asked to attribute an apparent age.ResultsDespite slight differences in severity between genders, men and women share in common a rather regular progression rate, correlated with perceived ages. 15% of men were judged older by more than 10 years, and all 5 signs were found more severe than the means of the other 85%. Forehead and Crow's feet wrinkles appear more pronounced in men. Ptosis is slightly more pronounced in women. Nasolabial fold does not differ. Marionette lines show distinct changes: those of men show a lessened severity and a slower rate of progression. In contrast with changes in facial signs with real ages, the upper face seems privileged in the perception of ages in women whereas the latter seems more focusing on its lower part in men.ConclusionThe facial skin aging process in Chinese subjects presents an almost linear progression with perceived ages, common to both genders, at the exception of marionette lines that are more marked and more rapidly progressing in women.
Different techniques for high‐throughput amplicon sequencing of the soil bacterial community structure after spring maize cultivation
Authors: Yang Yue , Tong Yan‐an , Chadwick Dave , Liang Lian‐you , Li Hong‐chang , Yan Yu‐mei , Han Wen‐she 
Published: June 2020

AbstractThe present study was a six‐year long‐term positioning experiment to explore the microbial community structure in the soil of spring maize under different cultivation techniques in rainfed areas. Five treatments were designed as follows: no fertilizer (CK); 135 kg ha‐1 N and 90 kg ha‐1 P under straw mulching (SM); plastic mulching (PM); ridge‐furrow with plastic film mulching (RFPFM) and green manure (GM). The results revealed that Actinobacteria (24%‐33%), Proteobacteria (23.6%‐33.4%), Acidobacteria (12.8%‐18%) and Firmicutes (0.6%‐3%) were the dominant phyla in different soil layers. The relative abundance (RA) of Actinobacteria in the surface soil layer (0–20 cm) of CK and GM (33.48% and 32.08%) was higher than that in the other treatments. Proteobacteria was richer at 0–20 cm than at 20–40 cm in all treatments. The RA of Proteobacteria in RFPFM (33.43%) was significantly (p < .05) greater than that in the other treatments, and the RA of Firmicutes (3.0%) in the RFPFM treatment at 20–40 cm was significantly (p < .05) greater. Chryseobacterium, Lactobacillus, Bacillus and Altererythrobacter were the dominant genera in PM, SM, GM and RFPFM, respectively. Solirubrobacter preferred soil with stable aggregates and was the dominant genus in the control treatment. The findings of this study demonstrated that changes in soil bacterial RA and community composition were significantly affected by mulching treatment.
Efficacy and safety of high‐dose intravenous iron as the first‐choice therapy in outpatients with severe iron deficiency anemia
Authors: Jericó Carlos , Beverina Ivo , Quintana‐Diaz Manuel , Salvadori Ugo , Melli Cristina , Rondinelli Maria Beatrice , Recasens Valle , Brando Bruno , Garcia‐Erce José Antonio 
Published: June 2020

BACKGROUNDAsymptomatic severe iron deficiency anemia is a common finding in subjects admitted to the outpatient anemia clinic. Although the condition can be easily be reversed with intravenous iron (IVI) therapy and several guidelines have suggested a restrictive threshold for using transfusion in hemodynamically stable patients, transfusion is often the rule in clinical practice. This study describes clinical practice results of IVI therapy without transfusion.STUDY DESIGN AND METHODSIn this multicenter retrospective observational study, data of severely anemic outpatients treated only with high‐dose IVI with ferric carboxymaltose were collected. Inclusion criteria were hemoglobin (Hb) level of less than 7.0 g/dL and ferritin level of less than 30 ng/mL or mean corpuscular volume of less than 75 fL.RESULTSOverall, 303 patients referred to the anemia clinic mainly from primary health care centers (46.2%) or the emergency department (28.7%) met the inclusion criteria. Median (interquartile range [IQR]) age was 47 (37‐62) years and 84.5% were female. The median (IQR) Hb concentration at first visit was 6.5 (6.1‐6.8) g/dL, 64 patients (21.1%) presented with a Hb level of less than 6.0 g/dL at diagnosis, and 11 of them (3.6%) had extreme anemia (Hb ≤ 5 g/dL). Gynecologic and gastroenteric bleeding were the main cause. After a mean IV administration of 1500 mg of iron, the Hb increased by a median of 5.7 g/dL. Thirteen patients experienced only mild side effects.CONCLUSIONSIn chronic very severe sideropenic anemias, third‐generation IVI is effective and safe for quick correction and avoidance of red blood cell transfusion. These results suggest that more specific guidelines for this clinical setting are warranted.
Shallow and Deep Artificial Neural Networks for Structural Reliability Analysis
Authors: Gomes Wellison José de Santana 
Published: June 2020

Abstract
Surrogate models are efficient tools which have been successfully applied in structural reliability analysis, as an attempt to keep the computational costs acceptable. Among the surrogate models available in the literature, artificial neural networks (ANNs) have been attracting research interest for many years. However, the ANNs used in structural reliability analysis are usually the shallow ones, based on an architecture consisting of neurons organized in three layers, the so-called input, hidden, and output layers. On the other hand, with the advent of deep learning, ANNs with one input, one output, and several hidden layers, known as deep neural networks, have been increasingly applied in engineering and other areas. Considering that many recent publications have shown advantages of deep over shallow ANNs, the present paper aims at comparing these types of neural networks in the context of structural reliability. By applying shallow and deep ANNs in the solution of four benchmark structural reliability problems from the literature, employing Monte Carlo simulation (MCS) and adaptive experimental designs (EDs), it is shown that, although good results are obtained for both types of ANNs, deep ANNs usually outperform the shallow ones.
Assisted manual skills using a clinical surveyor device: disruptive invention for spatial location
Authors: Ramirez Aristeguieta Luis Miguel , Lafaurie Ponce Luis Gabriel , Ramirez Rueda Luis Miguel , Puerta Uribe Estefania 
Published: June 2020

BackgroundGeometric and spatial relationships are essential for dental practice as a reference. Most manual procedures depend on the operator’s practice and ability, and they are non-assisted and non-controlled, depending on trial and error.AimDescribing the effectiveness of a disruptive innovation aimed at creating unwired technology (clinical surveyor device (CSD)) for assisting an operator’s manual skills/dexterity and controlling applications for training and clinical use in several areas of dentistry: rehabilitation, implants surgery and orthodontics.Materials and methodsTesting the device involved 25 odontology specialists and 20 10th semester undergraduate students and postgraduate residents. A paired Student t-test and Wilcoxon signed-rank test were used for comparison to ascertain whether there was a statistically significant difference when performing procedures with and without using a CSD. Biplot cluster analysis was used for understanding data structure and its variability, capturing variables and individuals’ inter-relationships.ResultA significant difference was found when using a CSD, which rejected the null hypothesis. There was no significant difference (p value of >0.05 regarding operators (experienced maxillofacial, periodontics and rehabilitators, periodoncy and rehabilitation programme final-year residents and 10th semester undergraduate students).ConclusionThe CSD’s advantages regarding accuracy would be related to controlling real hand position, enabling better-assisted operator skills and thereby creating confidence during rehabilitation/implant/orthodontic procedures.
Pain associated with psoriasis: systematic scoping review protocol
Authors: Sanader Vucemilovic Ana , Nujic Danijela , Puljak Livia 
Published: June 2020

IntroductionPsoriasis is a common chronic skin inflammatory disease. Its presentation, apart from affected skin areas, involves other unpleasant symptoms, such as pain. Pain deteriorates the patient’s quality of life, impairing their daily behaviour and functioning. Therefore, the alleviation of pain in patients with psoriasis should be one of the most desired outcomes of successful treatment. The aim of this study is to summarise available evidence about pain in patients with psoriasis using systematic scoping review methodology in order to map the relevant literature.Methods and analysesOur scoping systematic review will provide evidence synthesis of the literature, both quantitative and qualitative, about the pain associated with psoriasis, including pain associated with psoriatic arthritis. Any types of studies will be eligible for inclusion, and we will not have any time, language or publication status restrictions. We will search MEDLINE, Embase and PsycINFO via OVID, as well as Cochrane Central Register of Clinical Trials, Cochrane Database of Systematic Reviews via Cochrane Library, CINAHL via EBSCO, OpenGrey and ProQuest Dissertations and Theses Global. All databases will be searched from the date of their inception. Retrieved bibliographic records and potentially relevant full texts will be screened by two authors independently. Two researchers will extract data independently. Any discrepancies will be resolved via discussion or consultation of the third author, if necessary. To appraise studies, we will use a Mixed Methods Appraisal Tool, AMSTAR 2, Cochrane risk of bias tool and ROBINS. Our findings will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews.Ethics and disseminationThe proposed study will not be conducted with human participants. We will only use published data and therefore ethics approval is not required. Our findings will be disseminated via peer-reviewed manuscript and conference reports.
Patient, physiotherapist and surgeon endorsement of the core domain set for total hip and total knee replacement in Germany: a study protocol for an OMERACT initiative
Authors: Prill Robert , Singh Jasvinder A , Seeber Gesine H , Nielsen Sabrina Mai , Goodman Susan , Michel Sven , Kopkow Christian , Schulz Robert , Choong Peter , Hommel Hagen 
Published: June 2020

IntroductionThere is a lack of harmonising measures for clinical trials on total joint replacement (TJR) that would allow for results from TJR studies to be compared or pooled. The Outcome Measures in Rheumatology (OMERACT) TJR core domain set is already endorsed among patients and physicians in the USA and Australia. Physiotherapists use different types of measurements compared to orthopaedic surgeons while both make substantial contributions to research in the field of TJR. To achieve consensus on core measurements sets, patients, physiotherapists and orthopaedic surgeons need to achieve consensus on the core domains for TJR trials.Methods and analysisFor this multistage study, first, the OMERACT TJR core domain set survey will be translated to German and validated according to WHO guidelines. Next, the TJR core domain set will be considered for endorsement in different German stakeholder groups including patients, physiotherapists and orthopaedic surgeons.Ethics and disseminationEthical approval for this protocol was given by the ethics committee of the Brandenburg University of Technology Cottbus—Senftenberg (BTU—CS, EK 2019—2). This article is based on the protocol version 2.5 from 6 May 2020. Anonymous data will be presented only. We will publish the results in peer-reviewed publications and at international conferences.Trial registration numberGerman Clinical Trials Registry (DRKS00016015).
Protocol for creating new warnings on cigarette packs and evaluating their efficacy in a randomised experimental setting
Authors: Ben Lakhdar Christian , Deplancke Antoine , Le Lec Fabrice , Massin Sophie , Piermatteo Anthony , Vaillant Nicolas 
Published: June 2020

IntroductionTobacco smoking is one of the leading causes of preventable death. This is not inevitable as tobacco control tools have become more powerful and more effective. Among these, warnings on cigarette packs have proven to be somewhat effective. Our objective is to increase the efficacy of antismoking warnings by using innovative psychological approaches and to create an experimental setting for the evaluation of these new warnings based on behavioural indicators.Methods and analysisFirst, we created new warnings based on three categories of motivational leverage and on harm reduction. New warnings with innovative texts and pictures were designed for each category and inserted on plain packs. We will then use standard indicators to compare their effect to that of control packs: plain pack without warning, plain pack with conventional warning and branded pack with conventional warning. Second, the novelty of our approach will consist in designing an experimental protocol that uses monetary incentives to evaluate the effect of warnings. Subjects will be able to ‘sacrifice’ part of their participation defrayal to purchase a good whose subjective value is related to one’s attitude towards smoking. These monetarily incentivised measures are designed to assess smokers’ immediate/mid-term intention to quit and non-smokers’ aversion to smoking. In both cases, the monetary amounts individuals accept to sacrifice may be a more reliable measure than declarative responses, which may be distorted by several hypothetical biases. In the end, we should be able to robustly measure the impact of our new warnings between intervention and control groups by using both traditional indicators and our new monetarily incentivised measure.Ethics and disseminationThe ethics committee of theGroupement des Hôpitaux de l’Institut Catholique de Lilleapproved the research protocol on 5 July 2019 (CIER 2019-22). Results will be presented at scientific meetings and published.
Development of a core outcome set to use in the research and assessment of malignant bowel obstruction: protocol for the RAMBO study
Authors: Baddeley Elin , Bravington Alison , Johnson Miriam , Currow David C , Murtagh Fliss EM , Boland Elaine , Obita George , Nelson Annmarie , Seddon Kathy , Oliver Alfred , Noble Simon , Boland Jason 
Published: June 2020

IntroductionStudies regarding the management of malignant bowel obstruction (MBO) report conflicting findings. This is partly due to different outcome measures being used to evaluate severity of MBO and the response to treatments. Furthermore, current outcome measures focus mainly on measurable physiological parameters which may not correlate strongly with patient-defined quality of life. The development of core outcome sets allows a consistent approach to evaluating clinical conditions taking into consideration patient, healthcare professional and researcher viewpoints. It follows an internationally recognised standard methodology. We present a protocol for the development of a core outcome set for Research and Assessment of MBO (RAMBO).MethodsRAMBO is a multicentre study, comprising of four phases: a systematic review to examine current scope of outcome measures associated with MBO (phase I). Interviews with patients, companions and healthcare professionals will explore priorities and preferences for care and outcomes (phase II). An expert panel meeting will collate the findings into a set of outcomes (phase III), refined by consensus through a Delphi survey with key stakeholders (phase IV). The final set of outcomes will be ratified at a consensus meeting. Each step will actively include patient partners. Thematic analysis and descriptive statistics will be used to analyse qualitative and quantitative data, respectively.Ethics and disseminationEthical approval was obtained (Wales REC 5, REF: 19/LO/1876). Study participants and relevant stakeholders will be updated with newsletters and a lay summary at the end of the study. Abstracts will be submitted to national and international conferences, result papers will be submitted to peer-reviewed, open access journals.Trial and PROSPERO registration numbersCore Outcome Measures in Effectiveness Trials (1402); Systematic Literature Review (CRD42019150648); Rapid Review (CRD42020176393).
Biomodex patient-specific brain aneurysm models: the value of simulation for first in-human experiences using new devices and robotics
Authors: Yamaki Vitor Nagai , Cancelliere Nicole Mariantonia , Nicholson Patrick , Rodrigues Marta , Radovanovic Ivan , Sungur John-Michael , Krings Timo , Pereira Vitor M 
Published: June 2020

BackgroundWith the recent advent of advanced technologies in the field, treatment of neurovascular diseases using endovascular techniques is rapidly evolving. Here we describe our experience with pre-surgical simulation using the Biomodex EVIAS patient-specific 3D-printed models to plan aneurysm treatment using endovascular robotics and novel flow diverter devices.MethodsPre-procedural rehearsals with 3D-printed patient-specific models of eight cases harboring brain aneurysms were performed before the first in-human experiences. To assess the reliability of the experimental model, the characteristics of the aneurysms were compared between the patient and 3D models. The rehearsals were used to define the patient treatment plan, including technique, device sizing, and operative working projections.ResultsThe study included eight patients with their respective EVIAS 3D aneurysm models. Pre-operative simulation was performed for the first in-human robotic-assisted neurovascular interventions (n=2) and new generation flow-diverter stents (n=6). Aneurysms were located in both the anterior (n=5) and posterior (n=3) circulation and were on average 11.0±6.5 mm in size. We found reliable reproduction of the aneurysm features and similar dimensions of the parent vessel anatomy between the 3D models and patient anatomy. Information learned from pre-surgical in vitro simulation are described in detail, including an improved patient treatment plan, which contributed to successful first in-world procedures with no intraprocedural complications.ConclusionsPre-procedural rehearsal using patient-specific 3D models provides precise procedure planning, which can potentially lead to greater operator confidence, decreased radiation dose and improvements in patient safety, particularly in first in-human experiences.