bluuebunny/crossref_metadata_2025_split huggingface dataset:
Image-based bio-cad modeling: overview, scope, and challenges
Authors: Mangrulkar Amol , Rane Santosh , Sunnapwar Vivek 
Published: December 2020

Abstract
CAD used to facilitate engineering design, modeling, simulation, analysis, and manufacturing. Recent advancement in computer graphics, medical imaging, and Image processing created new ways for CAD in the design, modeling, and development of many novels and essential biomedical and non-biomedical applications. The Biomedical use to develop implant, scaffold, prostheses, surgical guide, and other medical devices. The non-medical use in forensic, anthropology, passenger safety product design, and impact analysis. This review article gives an overview of various recent approaches for the development of virtual Bio-CAD models from high resolution medical images. It shows how to choose the appropriate path as per the application's requirement in terms of its complexity and capturing features. Key publications from the reputed peer-reviewed journals and books have been reviewed and presented a different approach to develop Bio-CAD models from non-invasive medical imaging data. Different methods used to develop the interfaces are biomedical software, STL interface, and reverse engineering discussed from various research study have been explored. Recent advances in state-of-art technology such as CAD, medical imaging, and image processing, and reverse engineering techniques made it possible to easily reconstruct the 3D CAD models, which will be useful for other downstream applications. This study concludes that the Bio-CAD model plays a dominant role in all downstream applications for the design, analysis, simulation, and manufacturing of complex biomimetic scaffold, patient-specific implants, surgical guides, prosthesis, organ bio blueprints, and other biomedical models. The outcome from the literature review strongly suggested that Bio-CAD modeling will soon be the future for all medical practitioners, biomedical engineers, and manufacturers and will use in all computer-assisted surgery and planning. This paper is beneficial to study the development of Bio-CAD models techniques and its applications in design, modeling, analysis, and manufacturing of biomedical and nonbiomedical researchers.
Analysis of convective heat transfer over a square cylinder with rounded corners under steady flow regime at low Reynolds number
Authors: Bose S , Patle S D 
Published: December 2020

Abstract
This work deals with the numerical simulation of square cylinder with different rounded corners and numerical analysis of convective heat transfer is studied, here emphasis is being laid on both type of flow regime i.e. unsteady flow regime and steady flow regime i.e. between 40 ⩽ Re.⩽ 160 and Pr is kept as 0.7 and thus the finding suggests that the heat transfer increases significantly with rounded corners in square cylinder.
Experimental investigation on effect of zinc oxide nanofluid on performance, emission and combustion characteristics of CI engine fuelled with waste cooking oil biodiesel
Authors: Ramanathan V , Jaikumar M , Aleem Shaik Abdul , Induja S , SangeethKumar E 
Published: December 2020

Abstract
Environmental effluence and fossil fuels exhaustion are the main reasons to use alternate biofuels worldwide in engines. Many researchers focused their research on biodiesel which were extracted from eatable and non-eatable vegetable oils, used them in diesel engines. In this context, biodiesel derived from Waste Cooking Oil (WCO) was taken as a substitute fuel for diesel engine because of two reasons; one reason was some of the properties of this biodiesel were very nearer to diesel and another reason was giving second life to the waste cooking oil instead of disposing of in the land. In the first stage, Waste cooking oil Biodiesel (WCOB) was produced from WCO by transesterification process and experiment was carried out using diesel and WCOB and considered as base readings. In the second stage, Zinc oxide nanofluid in the mass proportions of 50ppm, 75ppm and 100 ppm were synthesised using a novel wet chemical method and blended with WCOB and considered fuels as WCOBZN50, WCOBZN75 and WCOBZN100 and their properties were tested. Then the experiment was conducted in a fully equipped engine test set up. The engine was loaded at various loading conditions. The readings were measured and analysed. The results exhibited that the blending of zinc oxide nanofluids with WCOB improved engine performance characteristics. Also, it was observed that the addition of zinc oxide nanofluids reduced the engine tailpipe emissions compared to neat WCOB. It was also found that the combustion characteristics of ZnO nano blended biodiesel were increased marginally.
Evaluation of effective location and thickness of shear wall on performance of multi-storey building subjected to lateral load
Authors: Shreelakshmi V , Kavitha S 
Published: December 2020

Abstract
The aim of the present study is to identify the optimum thickness of the shear divider and suitable position of shear divider in the structure. In this present study G+20 storeys building is considered which is positioned in a zone IV with soil type as medium. The linear static analysis method is used for analysis by using etabs 2016 software. We have considered four different thickness of shear wall such as 150mm, 175mm, 200mm and 225mm.and again considered the three different position in the buildings such as shear divider at corner, shear divider at mid span of the structure and core divider at center of the structure. The parameters considered are storey dislocation, storey drift, Overturning moment, base shear and modal time period.
Two dimensional rotor blade numerical analysis using ANSYS
Authors: Anand Shlok , Shenoy Satvik , Srinivas G 
Published: December 2020

Abstract
Turbo-pump is an essential component in any rocket engine. The airfoil (NGTE 10C4 series) section of a rotor blade in the SSME (Space Shuttle Main Engine) was modelled along with a far-field of suitable shape and dimensions. The model was suitably discretized with proper amount of refinement, etc. A numerical simulation was then carried-out using ANSYS software with several iterations of varying inlet boundary conditions to check for any improvement in the performance of the rotor blade. Inlet velocity for optimum functionality of the blade was identified.
Aerodynamic performance enhancement of missile using numerical techniques
Authors: Divakaran Raghuvaran , Barretto Nathan , Srinivas G 
Published: December 2020

Abstract
The objective of the paper is to conduct aerodynamic analysis on V-2 missile. The V-2 missile was the world’s first ballistic missile and the first object to go into space. It is a long-range liquid propelled missile. It uses aerodynamic surfaces such as wings, fins, control surfaces and fuselage to deliver the lateral maneuverability. This is accomplished by deflecting the control surfaces through the actuation mechanism and thereby modifying the equilibrium forces and producing various moments. The V-2 missile was 14 meters long and weighed 12,700–13,200 kg at launching. It produces about 266 KN of thrust.
ANSYS modeler is used to model the V-2 missile, and the flow around the missile body has been evaluated using the ANSYS workbench. This paper carried out simulations for varying angles of attack and Mach numbers until the stall was observed. Effects due to density, pressure coefficient, temperature and Mach number on the missile is noted in order to undergo detailed flow analysis.
Atrial fibrillation and stroke prevention: state of the art—epidemiology and pathophysiology: new risk factors, concepts and controversies
Authors: Kodani Eitaro , Akao Masaharu 
Published: December 2020

AbstractAtrial fibrillation (AF) increases the risk of thromboembolism, and risk assessment for thromboembolism is necessary for the management of AF patients. CHADS2 and CHA2DS2-VASc scores have been adopted in international guidelines for AF management, but the significance of each risk factor included in these risk scores are sometimes controversial, and the performance of these scores is only modest. There are several other risk factors not included in the scores such as renal dysfunction, low body weight, type of AF (paroxysmal or non-paroxysmal) as well as echocardiographic parameters and blood biomarkers, and physicians should assess patients risk in an integrated manner.
Ten years of non-vitamin K antagonists oral anticoagulants for stroke prevention in atrial fibrillation: is warfarin obsolete?
Authors: Hammwöhner Matthias , Goette Andreas 
Published: December 2020

AbstractCurrently, four non-vitamin K antagonists oral anticoagulants (NOACs) are available for stroke prevention in atrial fibrillation (AF). These have been in clinical use for up to 10 years now. Besides data of the initial phase III clinical trials, now clinical data, several sub-studies, meta-analyses, and studies in special clinical settings and specific patient populations are available. This review shall give an overview on the history of NOAC development, sum up study data and ‘real-world’ clinical data as well as discuss several special clinical settings like NOAC treatment in patients that require coronary artery stenting or cardioversion (CV). Furthermore, treatment considerations in special patient populations like patients with renal impairment, obesity, or patients requiring NOACs for secondary prevention are discussed. The significance of NOAC treatment will be discussed under consideration of the recently published 2020 ESC/EACTS Guidelines for the diagnosis and management of AF.
Tomboys in Sarah Grand’s New Woman Fiction
Authors: Moon Jina 
Published: December 2020

Abstract
Sarah Grand’s The Beth Book (1897) and Babs the Impossible (1901) both feature overtly tomboyish protagonists, in what I argue is an effort to shift notions of femininity and gender identity and to adopt gender-neutral qualities as features of the New Woman – qualities such as independence, comradeship, and loyalty to other human beings. In this essay, I argue that Grand attempted to soften resistance to the New Woman by focusing on tomboyism in childhood (utilizing people’s tendency to feel favourably towards children) and then extending tomboy qualities to New Womanhood while providing the Victorian public with an exemplar of independent and robust femininity. The critical difference between a prototypical tomboy figure and the one in New Woman fiction is that the latter keeps their tomboyism after maturity, sublimating the trait into her inborn self, faithful to herself and her ideas. Beyond the trope of the childhood tomboy, Grand aimed to bolster and strengthen womanhood by adopting tomboyism as an extension of a inborn self and redefine notions of acceptable female behaviour, thereby expanding the scope of womanhood.
Comparison of calorie and nutrient intake among elderly with and without sarcopenia: A systematic review and meta-analysis
Authors: Santiago Emanuelle C S , Roriz Anna K C , Ramos Lílian B , Ferreira Andrêa J F , Oliveira Carolina C , Gomes-Neto Mansueto 
Published: December 2020

AbstractContextSarcopenia, besides having an impact on functional capacity, has been associated with increased hospitalization and mortality, and stands out as an essential cause of disability among older people.ObjectiveWe conducted a systematic review and meta-analysis of published studies comparing the calories and nutrients ingested by elderly people with and without sarcopenia.Data sourcesMEDLINE/PubMed, Scopus, LILACS, Cochrane Library, and Scielo databases were searched.Study SelectionStudies comparing calories and nutrient intake among elderly people diagnosed with sarcopenia and people without sarcopenia were included.Data AnalysisMean differences and 95% confidence intervals (CIs) were calculated, and heterogeneity was assessed using I2 test.ResultsA total of 23 studies fulfilled the inclusion criteria. The average number of calories and nutrients ingested were significantly lower in elderly study participants with sarcopenia compared with those without sarcopenia. The meta-analyses showed that the average number of calories ingested (n = 19 studies; mean difference, −156.7 kcal; 95%CI, −194.8 to −118.7) were significantly lower in those with sarcopenia than in elderly participants without sarcopenia. Compared to those without sarcopenia, elderly people with sarcopenia consumed lower amounts of proteins; carbohydrates; saturated fatty acids; vitamins A, B12, C, and D; and minerals such as calcium, magnesium, sodium, and selenium.ConclusionsThe evidence so far available suggests a difference in caloric, macronutrient (ie, proteins, carbohydrates, saturated fatty acids), and micronutrient (ie calcium, magnesium, sodium, selenium, and vitamins A, B12, C, and D) intake among the elderly with and without sarcopenia. Additional studies are needed to define the best interventions to improve the consumption of calories and nutrients by the aging population.
Urban collective garden participation and health: a systematic literature review of potential benefits for free-living adults
Authors: Tharrey Marion , Darmon Nicole 
Published: December 2020

AbstractContextCollective gardens are increasingly considered a tool to promote health and well-being.ObjectiveIn this systematic review, we critically appraise quantitative studies exploring the potential health benefits of urban collective garden participation.Data SourcesArticles published between January 2000 and August 2020 were used.Data ExtractionAll original research studies reporting at least 1 health outcomes associated with urban collective gardening in free-living adults from Western and other high-income countries were included. Of 1261 articles identified, 15 were included in the systematic review. Methodological quality was assessed by applying the criteria of the Quantitative Study Quality Assessment Tool.AnalysisA wide range of health indicators was used. Collective gardening was associated with higher fruit and vegetable consumption than was nongardening. Mixed results were found for physical activity and physiological health. A positive association was found in most studies with mental health and social health. However, the vast majority of included studies were cross-sectional and presented selection bias (n = 13 of 15 for both) and very few used objective measurement methods (n = 3 of 15).ConclusionsLongitudinal studies allowing the exploration of causal relationships are needed before the health benefits of collective garden participation suggested by existing studies can be confirmed.
From Mobsters to Magnates: Shifting Blame for Modern Slavery in Australian Parliamentary Inquiries
Authors: O’Brien Erin 
Published: December 2020

AbstractPolicy problems are typically framed through a representation of those who have been harmed, and those who are to blame, with parliamentary inquiries playing a key role in setting the agenda by mediating between competing problematisations. In order to reveal the politics behind policy-making through inquiries, it is necessary to examine both the aspects of the issue that are problematised and those aspects that remain unproblematised. Adopting modern slavery policy in Australia as a case study, this article utilises Bacchi’s ‘what is the problem represented to be?’ framework for analysing discourse in parliamentary inquiries on modern slavery between 2003 and 2018. I argue that across three clear phases of policy-making, problematisation has shifted and evolved, though blame has consistently been deflected away from the role of the state in contributing to the conditions that cause modern slavery.
Comparison of breast ductal carcinoma in situ and ductal carcinoma in situ with microinvasion, and analysis of axillary lymph node metastasis
Authors: Zhang Geng , Li Chunxiao , Tian Guo , Cheng Xiaozhi , Li Yilun , Ma Li 
Published: December 2020

Abstract
To compare the clinicopathologic features and long-term outcomes for women with ductal carcinoma in situ (DCIS) vs DCIS with microinvasion (DCISM), to assess the impact of microinvasion on tumor size and determine relationships between the number of microinvasive lesions and clinicopathological factors.
A total of 493 patients with DCIS or DCISM from our database were analyzed to assess differences in clinicopathologic features and outcomes between the 2 cohorts.
The median follow-up was 3.9 years, 229 patients had DCIS and 264 had DCISM, and the mean age was 46.8 years for the entire group. A total of 208 patients underwent axillary operation in the DCIS cohort vs 246 in the DCISM cohort, and the number of lymph node metastasis cases was 0 vs 13 for the 2 groups. For the lymph node-positive cases, the proportion of patients with no less than 3 microinvasive legions was 61.5% (8/13), while in the lymph node-negative group, the proportion of patients was 31.1% (78/251) (P < .05). For the DCIS and DCISM groups, the relapse-free survival (RFS) values were 99.0% and 95.4% (P = .034), while the overall survival (OS) values were 96.2% and 99.2% (P = .032), respectively.
Our data imply that for breast DCIS patients, axillary lymph node operation can be avoided, but for DCISM patients, surgical evaluation of the axilla is necessary. In addition, having no less than 3 microinvasive lesions in DCISM indicates poor prognosis. In the pathological staging of DCISM, tumor size and number of microinvasive lesions should be considered.
Halomonas icarae sp. nov., a moderately halophilic bacterium isolated from beach soil in India
Authors: Pandiyan Kuppusamy , Kushwaha Prity , Bagul Samadhan Y. , Chakdar Hillol , Madhaiyan Munusamy , Krishnamurthi Srinivasan , Kumar Pravin , Karthikeyan Nanjappan , Singh Arjun , Kumar Murugan , Singh Udai Bhan , Saxena Anil Kumar 
Published: December 2020

A moderately halophilic, Gram-stain-negative, aerobic bacterium, strain D1-1T, belonging to the genus

Halomonas

, was isolated from soil sampled at Pentha beach, Odisha, India. Phylogenetic trees reconstructed based on 16S rRNA genes and multilocus sequence analysis of gyrB and rpoD genes revealed that strain D1-1T belonged to the genus

Halomonas

and was most closely related to

Halomonas alimentaria

YKJ-16T (98.1 %) followed by

Halomonas ventosae

Al12T (97.5 %),

Halomonas sediminicola

CPS11T (97.5 %),

Halomonas fontilapidosi

5CRT (97.4 %) and

Halomonas halodenitrificans

DSM 735T (97.2 %) on the basis of 16S rRNA gene sequence similarity. Sequence identities with other species within the genus were lower than 97.0 %. The digital DNA–DNA hybridization (dDDH) and average nucleotide identity (ANI) values of 22.4–30 % and 79.5–85.4 % with close relatives of

H. halodenitrificans

DSM 735T,

H

.

alimentaria

YKJ-16T,

H. ventosae

Al12T and

H. fontilapidosi

5CRT were lower than the threshold recommended for species delineation (70 % and 95–96 % for dDDH and ANI, respectively). Further, strain D1-1T formed yellow-coloured colonies; cells were rod-shaped, motile with optimum growth at 30 °C (range, 4–45 °C) and 2–8 % NaCl (w/v; grew up to 24 % NaCl). The major fatty acids were summed feature 8 (C18 : 1
ω7c/C18 : 1
ω6c), summed feature 3 (C16 : 1
ω7c/C16 : 1
ω6c) and C16 : 0 and the main respiratory quinone was ubiquinone Q-9 in line with description of the genus. Based on its chemotaxonomic and phylogenetic characteristics and genome uniqueness, strain D1-1T represents a novel species in the genus

Halomonas

, for which we propose the name Halomonas icarae sp. nov., within the family

Halomonadaceae

. The type strain is D1-1T (=JCM 33602T=KACC 21317T=NAIMCC-B-2254T).
Targeted quantification of phosphorylation sites identifies STRIPAK-dependent phosphorylation of the Hippo pathway-related kinase SmKIN3
Authors: Stein Valentina , Blank-Landeshammer Bernhard , Märker Ramona , Sickmann Albert , Kück Ulrich 
Published: December 2020

AbstractWe showed recently that the germinalcentrekinase III (GCKIII) SmKIN3 from the fungusSordaria macrosporais involved in sexual development and hyphal septation. Our recent extensive global proteome and phosphoproteome analysis revealed that SmKIN3 is a target of thestriatininteractingphosphataseandkinase (STRIPAK) multi-subunit complex. Here, using protein samples from wild type and three STRIPAK mutants, we applied absolute quantification byparallelreactionmonitoring (PRM) to analyze phosphorylation site occupancy in SmKIN3 and otherseptationinitiationnetwork (SIN) components, such as CDC7 and DBF2, as well as BUD4, acting downstream of SIN. For SmKIN3, we show that phosphorylation of S668 and S686 is decreased in mutants lacking distinct subunits of STRIPAK, while a third phosphorylation site, S589, was not affected. We constructed SmKIN3 mutants carrying phospho-mimetic and phospho-deficient codons for phosphorylation sites S589, S668 and S686. Investigation of hyphae in a ΔSmKin3 strain complemented by the S668 and S686 mutants showed a hyper-septation phenotype, which was absent in the wild type, the ΔSmKin3 strain complemented with wild type gene, or the mutant S589. Furthermore, localization studies with SmKIN3 phosphorylation variants and STRIPAK mutants showed that SmKIN3 preferentially localizes at the terminal septa, which is distinctly different from the wild type strains. We conclude that STRIPAK-dependent phosphorylation of SmKIN3 has an impact on controlled septum formation and on the time-dependent localization of SmKIN3 on septa at the hyphal tip. Thus, STRIPAK seems to regulate SmKIN3, as well as DBF2 and BUD4 phosphorylation, affecting septum formation.
C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxin
Authors: O’Loughlin Elaine , Jacob Binod , Zeballos Gonzalo , Manfre Philip , McCullough Anjali , Gatto Nicholas Thomas , Tsuchiya Takayuki , Karkkainen Anna-Mari , Lehtimäki Kimmo , Kuosmanen Juha , Rosahl Thomas W. , Varty Geoffrey B. , Kennedy Matthew E. , Mirescu Christian , Bardehle Sophia 
Published: December 2020

AbstractAdvances in our understanding of cellular functions and phenotypes in the brain rely on technically robust experimentalin vivomodels with face validity towards human disease. The cuprizone toxin-induced demyelination model is widely used to investigate pathophysiological mechanisms of demyelinating and remyelinating phases of multiple sclerosis. The C57BL6 mouse is a common inbred strain used as the genetic background for genetically engineered and congenic mice. Substrains of C57BL6 mice sourced from distinct vendors are often treated as equivalent in research studies. Here, we demonstrated that an alternative dosing approach via oral gavage with a well-tolerated, lower dose of cuprizone resulted in significant differences in C57BL/6NTac (Taconic) over C57BL/6J (Jax) mice. With consistent dosing of cuprizone for 5 weeks, body weights were significantly affected in C57BL/6NTac versus C57BL/6J mice. DT-MRI showed significant demyelination in white matter regions in the C57BL/6NTac mice. Concomitantly, histology analysis illustrated increased microgliosis and proliferation in C57BL/6NTac compared with C57BL/6J mice. These observations suggest that the C57BL/6NTac substrain of C57BL6 mice is more vulnerable to cuprizone challenge. Genetic factors along with breeder source appear to influence susceptibility to cuprizone toxin. Thus, the awareness of the limitations ofin vivomodels in addition to informed decision making on the appropriate background substrain can greatly improve sensitivity and reproducibility of results and use for evaluating investigational therapeutics.