bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defensive forwards: stress-responsive proteins in cell walls of crop plants
Authors: Niu Liangjie , Wang Wei 
Published: February 2020

ABSTRACTAs the vital component of plant cell wall, proteins play important roles in stress response through modifying wall structure and involving in wall integrity signaling. However, the potential of cell wall proteins (CWPs) in improvement of crop stress tolerance has probably been underestimated. Recently, we have critically reviewed the predictors, databases and cross-referencing of subcellular locations of possible CWPs in plants (Briefings in Bioinformatics2018;19:1130-1140). In this study, taking maize (Zea mays) as an example, we retrieved 1873 entries of probable maize CWPs recorded in UniProtKB. As a result, 863 maize CWPs are curated and classified as 59 kinds of protein families. By referring to GO annotation and gene differential expression in Expression Atlas, we highlight the potential of CWPs as defensive forwards in abiotic and biotic stress responses. In particular, several CWPs are found to play key roles in adaptation to many stresses. String analysis also reveals possibly strong interactions among many CWPs, especially those stress-responsive enzymes. The results allow us to narrow down the list of CWPs to a few specific proteins that could be candidates to enhance maize resistance.
Immunoinformatic design of multi epitopes peptide-based universal cancer vaccine using matrix metalloproteinase-9 protein as a target
Authors: Abdelmoneim Abdelrahman H. , Mustafa Mujahed I. , Abdelmageed Miyssa I. , Murshed Naseem S. , Dawoud Enas A. , Ahmed Enas M. , Kamal eldin Rahma M. , Elfadol Nafisa M. , Sati Anfal Osama M. , Makhawi Abdelrafie M. 
Published: February 2020

AbstractBackgroundCancer remains a major public health hazard despite the extensive research over the years on cancer diagnostic and treatment, this is mainly due to the complex pathophysiology and genetic makeup of cancer. A new approach toward cancer treatment is the use of cancer vaccine, yet the different molecular bases of cancers reduce the effectiveness of this approach. In this work we aim to use matrix metalloproteinase-9 protein (MMP9) which is essential molecule in the survival and metastasis of all type of cancer as a target for universal cancer vaccine design.Methodreference sequence of matrix metalloproteinase-9 protein was obtained from NCBI databases along with the related sequence, which is then checked for conservation using BioEdit, furthermore the B cell and T cell related peptide were analyzed using IEDB website. The best candidate peptide were then visualized using chimera software.ResultThree Peptides found to be good candidate for interactions with B cells (SLPE, RLYT, and PALPR), while ten peptides found as a good target for interactions with MHC1 (YRYGYTRVA, YGYTRVAEM, YLYRYGYTR, WRFDVKAQM, ALWSAVTPL, LLLQKQLSL, LIADKWPAL, KLFGFCPTR, MYPMYRFTE, FLIADKWPA) with world combined coverage of 94.77%. In addition, ten peptides were also found as a good candidates for interactions with MHC2 (KMLLFSGRRLWRFDV, GRGKMLLFSGRRLWR, RGKMLLFSGRRLWRF, GKMLLFSGRRLWRFD, TFTRVYSRDADIVIQ, AVIDDAFARAFALWS, FARAFALWSAVTPLT, MLLFSGRRLWRFDVK, GNQLYLFKDGKYWRF, NQLYLFKDGKYWRFS), with world combined coverage of 90.67%.CONCLUSION23 peptide-based vaccine was designed for use as a universal cancer vaccine which has a high world population coverage for MHC1(94.77%) and MHC2 (90.67%) related alleles.
Roles of the ClC Chloride Channel CLH-1 in Food-associated Salt Chemotaxis Behavior ofC. elegans
Authors: Park Chanhyun , Sakurai Yuki , Sato Hirofumi , Kanda Shinji , Iino Yuichi , Kunitomo Hirofumi 
Published: February 2020

AbstractThe ability of animals to process dynamic sensory information facilitates foraging in an ever changing environment. However, molecular and neural mechanisms underlying such ability remain elusive. The ClC anion channels/transporters play a pivotal role in cellular ion homeostasis across all phlya. Here we find a ClC chloride channel is involved in salt concentration chemotaxis ofC. elegans. Genetic screening identified two altered-function mutations ofclh-1that disrupt experience-dependent salt chemotaxis. Using genetically encoded fluorescent sensors, we demonstrate that CLH-1 contributes to regulation of chloride and calcium dynamics of salt-sensing neuron, ASER. The mutant CLH-1 reduced responsiveness of ASER to salt stimuli in terms of both temporal resolution and intensity, which could disrupt navigation strategies for approaching preferred salt concentration. Furthermore, other ClC genes appeared to act redundantly in salt chemotaxis. These findings provide insights into the regulatory mechanism of neuronal responsivity by ClCs that contribute to modulation of navigation behavior.
Kwality Ltd.: the banker’s dilemma
Authors: Mathur Sachin 
Published: February 2020

Learning outcomes
The case provides an opportunity to the students to learn some of the analytical processes in making a credit decision, including interpretation of financial ratios for credit analysis, forecasting a stress scenario, analysing cash flow adequacy, assessment of financial flexibility and, finally, recommend a credit decision.

Case overview/synopsis
The case discusses the analytical challenges facing a bank credit officer while assessing the credit quality of Kwality Ltd., an India-based dairy product manufacturer. Kwality Ltd. had undertaken a significant capacity expansion and business transformation to strengthen its market position in value-added dairy products business and improve its profit margins. The capacity expansion had recently been completed and the management, credit rating agency, equity analysts and investors appear to be optimistic regarding the company’s prospects. However, the capital investment had been almost entirely debt-funded and large long-term debt repayments would have become due shortly. The company had also built up large trade receivables. The banker had to assess if Kwality would be in a position to repay its debt and should his bank increase working capital disbursement to the company.

Complexity academic level
Complexity: Academic level. Applicability: MBA, Executive MBA.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS1: Accounting and Finance.
Trouble on the shop floor
Authors: Jordaan Barney , Cillié Gawie 
Published: February 2020

Supplementary materials
The case is supported with a teaching note, discussion questions and suggested responses to those as well as verbatim transcripts from interviews conducted with managers and others for purposes of a research project after the strike had ended. Teaching Notes are available for educators only.

Learning outcomes
The learning outcomes are as follows: students will be able to critique the approach to collective bargaining of both the company and the union in the case and suggest alternative approaches; identify the steps the company could take to both deal with the aftermath of the strike and develop preventive measures for the future; and advise the company on a series of questions it needs advice on.

Case overview/synopsis
A violent strike erupted after failed wage negotiations. It laid bare deep divisions between African and non-African employees and between permanent employees and those appointed as temporary employees only. It also revealed the mindsets of people on both sides of the conflict, as well as several errors made by management in the manner in which they viewed the role of the union and failed to build strong relations with employees on the shop floor.

Complexity academic level
The case is suitable for students at honours or masters level in conflict studies, dispute resolution, employment relations, human resource management and negotiation.

Subject code
CSS 6: Human resource management.
Assessment of post-heat behavior of cement mortar incorporating silica fume and granulated blast-furnace slag
Authors: Pachideh Ghasem , Gholhaki Majid 
Published: February 2020

Purpose
With respect to the studies conducted so far and lack of researches on the post-heat behavior of cement mortars containing pozzolanic materials, the purpose of this paper is to investigate the post-heat mechanical characteristics (i.e. compressive, tensile and flexural strength) of cement mortars containing granulated blast-furnace slag (GBFS) and silica fume (SF). In doing so, selected temperatures include 25, 100, 250, 500, 700 and 9000c. Last, the X-ray diffraction test was conducted to study the microstructure of mixtures and subsequently, the results were presented as power-one mathematical relations.

Design/methodology/approach
Totally, 378 specimens were built to conduct flexural, compressive and tensile strength tests. Accordingly, these specimens include cubic and prismatic specimens with dimensions of 5 × 5 × 5 cm and 16 × 4 × 4 cm, respectively, to conduct compressive and flexural strength tests together with briquette specimen used for tensile strength test in which cement was replaced by 7, 14 and 21 per cent of SF and GBFS. To study the effect of temperature, the specimens were heated. In this respect, they were heated with a rate of 5°C/min and exposed to temperatures of 25 (ordinary temperature), 100, 250, 500, 700 and 900°C.

Findings
On the basis of the results, the most profound effect of using GBFS and SF, respectively, takes place in low (up to 250°C) and high (500°C and greater degrees) temperatures. Quantitatively, the compressive, tensile and flexural strengths were enhanced by 73 and 180 per cent, 45 and 100 per cent, 106 and 112 per cent, respectively, in low and high temperatures. In addition, as the temperature elevates, the particles of specimens containing SF and GBFS shrink less in size compared to the reference specimen.

Originality/value
The specimens were cured according to ASTMC192 after 28 days placement in the water basin. First, in compliance with what has been specified by the mix design, the mortar, including pozzolanic materials and superplasticizer, was prepared and then, the sampling procedure was conducted on cubic specimens with dimension of 5 × 5 × 5 mm for compressive strength test, prismatic specimens with dimensions of 16 × 4 × 4 mm for flexural strength test and last, briquette specimens were provided to conduct tensile strength tests (for each temperature and every test, three specimens were built).
Intraocular tumour necrosis factor ligand related molecule 1 A links disease progression of proliferative diabetic retinopathy after primary vitrectomy
Authors: Wang Tian , Li Jianan , Xie Ruotian , Wang Jiaxing , Zhang Wei , Jiang Feng , Du Mei , Wang Xiaohong , Huang Bo , Brant Rodrigo , Zhang Cheng , Yan Hua 
Published: February 2020

AbstractTumour necrosis factor ligand related molecule 1 A (TL1A), a member of tumour necrosis factor superfamily, has been identified as a crucial regulator for vascular homeostasis and inflammation. However, the function of TL1A in diabetic retinopathy (DR) is largely unknown. This study aims to examine levels of TL1A in serum and intraocular fluid in patients with proliferative diabetic retinopathy (PDR), and to explore the correlation of intraocular TL1A with the prognosis of PDR progression after primary vitrectomy. Seventy‐five patients (75 eyes) with PDR who underwent pars plana vitrectomy (PPV) and 19 patients (19 eyes) who received vitrectomy for idiopathic macular holes (IMH) as non‐diabetic control group were enrolled in this prospective study. Serum, aqueous and vitreous fluid samples were collected during cataract and PPV surgery. Protein expressions of TL1A as well as other angiogenic and inflammatory cytokines in serum and intraocular fluid were measured. Correlations of intraocular TL1A concentrations with inflammatory cytokines were analyzed. We found both aqueous and vitreous TL1A levels were significantly higher in the PDR group than in control group (Paqueous = 0.026;Pvitreous<0.001). Angiogenic and inflammatory cytokines such as VEGF, IL‐6, IL‐8, MCP‐1, MIP‐1α, and MIP‐1β were significantly higher in intraocular fluid in PDR group than in controls, which MCP‐1 and MIP‐1α showed positive correlation with intraocular TL1A levels. There is no significant difference in the levels of serum TL1A as well as other inflammatory cytokines between PDR patients and controls. Intraocular levels of TL1A were significantly lower in PDR progression group than in the stable group (Paqueous<0.001;Pvitreous<0.001). Multivariate logistic regression analyses revealed that lower levels of intraocular TL1A was an important risk factor for predicting PDR progression after primary PPV (ORaqueous = 0.717,Paqueous = 0.001; ORvitreous = 0.684;Pvitreous = 0.002). In conclusion, TL1A and multiple inflammatory cytokines were highly enriched in the intraocular fluid of PDR patients compared with the controls. Lower levels of intraocular TL1A were associated with development of PDR complications after primary PPV and might be used as prognostic factor in predicting the vitrectomy outcome in PDR patients.
The Invisible Man of Indecency: Profanity and the Letters of the Late Ignatius Sancho, an African (1782)
Authors: Saillant John 
Published: February 2020

AbstractThis essay analyses vulgarities in Ignatius Sancho's letters, which were collected and published posthumously (in 1782) by one of his correspondents to provide revenue for Sancho's widow and children. It proposes a role for Sancho in English letters never previously suggested: that he used sexual innuendo in the manner of Swift, Sterne and London playwrights to spur a number of patrons and benefactors to provide gifts of money, food and other necessities when he had difficulty feeding his children. The posthumous collection continued that effort but elided some of his frankness, possibly because Sancho's widow was involved in its publication.
Functional Health in Korean Middle‐Aged Women with Poor Sleep Quality
Authors: Kim Go‐Un , Park Suin , Kim Sunah 
Published: February 2020

PURPOSETo develop and test a structural model of functional health in middle‐aged women based on the theory of unpleasant symptoms.METHODSThe direct and indirect effects of menopause status, childhood trauma, post‐traumatic stress, social support, and sleep quality on functional health of 264 Korean women were examined.FINDINGSMenopause status and poor sleep quality had a negative direct effect and social support had a positive direct effect on functional health. Menopause status had a negative indirect effect on functional health through poor sleep quality.CONCLUSIONSBiopsychosocial nursing intervention programs need to be developed to improve functional health in middle‐aged women.IMPLICATIONS FOR NURSING PRACTICEIt is important to mediate quality of sleep to improve functional health in middle‐aged women.목적불쾌증상 이론을 바탕으로 중년 여성의 건강기능을 평가하기 위함이다.방법264명의 한국 여성을 대상으로 건강기능에 영향을 미치는 폐경, 아동기 외상, 외상 후 스트레스, 사회적 지지의 직ㆍ간접적 영향을 확인하였다.결과폐경과 낮은 수면의 질은 건강기능에 부적 영향을 미쳤으며, 사회적 지지는 건강기능에 정적 영향을 미쳤다. 폐경은 건강기능에 간접적 영향을 미쳤다.결론중년여성의 건강기능을 증진하기 위해 신체ㆍ심리ㆍ사회적 요인을 고려한 통합적 중재가 필요하다.간호실무 적용점: 중년여성의 건강기능을 유지하기 위해 수면의 질을 중재하는 것이 중요하다.
Measuring Agreement Among Prehospital Providers and Physicians in Patient Capacity Determination
Authors: O'Connor Laurel , Porter Liam , Dugas Julianne , Robinson Conor , Carrillo Eli , Knowles Kenneth , Nelson Kerrie P. , Gigliotti Ronald , Tennyson Joseph , Weisberg Stacy , Rebesco Matthew 
Published: February 2020

AbstractObjectivesIf a patient wishes to refuse treatment in the prehospital setting, prehospital providers and consulting emergency physicians must establish that the patient possesses the capacity to do so. The objective of this study is to assess agreement among prehospital providers and emergency physicians in performing patient capacity assessments.MethodsThis study involved 139 prehospital providers and 28 emergency medicine physicians. Study participants listened to 30 medical control calls pertaining to patient capacity and were asked to interpret whether the patients in the scenarios had the capacity to refuse treatment. Participants also reported their comfort level using modified Likert scales. Inter‐rater reliability was calculated utilizing Fleiss' and Model B kappa statistics. Fisher's exact tests were used to calculate p‐values comparing the proportion in each cohort that responded “no capacity.” Primary outcomes included inter‐rater reliability in the physician and prehospital provider cohorts.ResultsThe inter‐rater agreement between the physicians was low (Fleiss' kappa = 0.31, standard error [SE] =0.06; model‐based kappa = 0.18, SE = 0.04). Agreement was similarly low for the 135 prehospital providers (Fleiss' kappa = 0.30, SE = 0.06; model‐based kappa = 0.28, SE = 0.04). The difference between the proportion of physicians and prehospital providers who responded “no capacity” was statistically significant in five of 30 scenarios. Median prehospital provider and physician confidence, on a 1 to 4 scale, was 2.00 (Q1–Q3 = 1.00–3.00 for prehospital providers and Q1–Q3 =1.0–2.0 for physicians).ConclusionsThere was poor inter‐rater reliability in capacity determination between and among the prehospital provider and physician cohorts. This suggests that there is need for additional study and standardization of this task.
Ageing as part of the curriculum for health‐care professionals: A Queensland Survey
Authors: Liddle Jacki , Beattie Elizabeth , Gannon Brenda , Bennett Sally , Pachana Nancy A. 
Published: February 2020

AbstractObjectivesEducation affects the attitudes and abilities of health professionals regarding older people. This study examines the nature and amount of ageing‐related content in programs at universities and in continuing education in Queensland for disciplines involved in the direct care of older people.MethodsSurveys developed for the different settings were sent to universities and health professional representative bodies.ResultsRepresentatives from thirty (of 71) programs and 12 (of 22) professional bodies responded. Many program representatives (62%) reported ageing content was at an appropriate level. The remainder indicated it was too low. Representatives from professional bodies identified ageing was a priority (81%) and offered ageing‐related education (72%). Time spent on ageing in university programs varied widely (median of 67 hours [interquartile range: 222.5]). Qualitative feedback indicated tensions existed about accreditation standards and perceptions of ageing as a specialty versus a core practice area.ConclusionAgeing‐related education for health professionals requires attention to address shortcomings.
Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single‐centre study
Authors: Young Rebekah , Snow Hayden , Hendry Shona , Mitchell Catherine , Slavin John , Schlicht Stephen , Na Lumine , Hofman Michael S. , Gyorki David E. 
Published: February 2020

AbstractBackgroundRetroperitoneal sarcomas are rare soft tissue tumours accounting for 10–15% of soft tissue sarcomas. Patient prognosis and treatment recommendations (including extent of surgery and neoadjuvant strategies) are determined by the pre‐operative histopathological subtype and grade obtained from biopsy and thus it is important to understand the accuracy of biopsy in retroperitoneal masses.MethodsThis study presents a case series of primary retroperitoneal sarcomas managed at Peter MacCallum Cancer Centre (PMCC) between 2008 and 2019. Statistical analyses were performed to determine correlation between histopathology from percutaneous biopsy and surgical excision.ResultsA total of 117 patients who underwent percutaneous core biopsy and surgical excision of retroperitoneal sarcoma were included. Diagnostic accuracy varied with histopathological diagnosis, but overall precise concordance between biopsy and final histopathology was seen in 61% (κ = 0.57). Biopsy was most sensitive for identifying well‐differentiated liposarcoma (WDLPS) (sensitivity 85%, 95% CI 0.06–0.96) and leiomyosarcoma (sensitivity 81%, 95% CI 0.54–0.96) and was least sensitive for identifying de‐differentiated liposarcoma (DDLPS) (sensitivity 40%, 95% CI 0.25–0.56). Overall agreement between biopsy and final histopathology increased with use of PET/CT scan pre‐biopsy and with use of fluorescence in situ hybridisation testing on biopsy, however, neither test improved recognition of de‐differentiated components within WD/DDLPS on core biopsy.ConclusionsPre‐operative biopsy is important for clinical decision making in the treatment of retroperitoneal sarcoma. A significant portion of patients with a WDLPS will have a de‐differentiated component identified at the time of resection that was not identified on initial biopsy.
Criminal History, Sex, and Employment: Sex Differences in Ex‐Offender Hiring Stigma
Authors: Holloway Colin P. , Wiener Richard L. 
Published: February 2020

AbstractCommunities across the United States integrate thousands of men and women coming out of jail or prison each year and studies suggest that over 75% of this population will reoffend within a decade of release. According to research, positive employment outcomes are linked to preventing recidivism; however, employers routinely check or inquire about criminal histories and discriminate against ex‐offender applicants. The current research focused on employer stigma against applicants with a criminal history with an online sample of adults (N = 296). The analogue experiment examined hiring decisions for Black versus White applicants with or without a criminal history in order to explore the effect of race and criminal history on hiring outcomes. As expected, participants were less likely to recommend applicants with a criminal history for employment, but the sex of the respondent moderated the differences in racial bias. Male hiring decision makers did not differentiate between applicants with or without a criminal history when presented with a White applicant but did show a stigma against Black ex‐offenders versus Black applicants with a clean criminal history. Female hiring decision makers showed the opposite pattern demonstrating no preference between Black applicants with or without a criminal history but preferring White applicants without a criminal record versus White ex‐offenders. These findings suggest that male and female hiring managers are differently affected by the presence of a criminal history depending on the race of the applicant and these differences if replicated have interesting policy implications.