bluuebunny/crossref_metadata_2025_split huggingface dataset:
O fazer verdadeiro e a transição de governo na construção da Base Nacional Comum Curricular: um documento também político
Authors: Merith-Claras Sônia 
Published: October 2019

Estudar o jogo de persuasão entre enunciador e enunciatário nos possibilita reconhecer, nos discursos, o fazer verdadeiro que se quer produzir por meio de estratégias, dos recursos de linguagem utilizados. Nesse sentido, tomando as versões publicadas da Base Nacional Comum Curricular (BNCC) como objeto de estudo - três versões apresentadas para consulta pública (2015, 2016, 2017a), mais a versão homologada (2017b) – nosso intuito é reconhecer como o enunciador se apropria da linguagem no jogo de manipulação estabelecido entre ele e seu enunciatário, buscando, em cada versão, estabelecer um fazer crer, por meio de um fazer verdadeiro. Nosso propósito, ainda, é evidenciar como a transição de governo vai resultar em modificações na estrutura, perspectivas adotadas em cada versão apresentada, levando-nos a reconhecer a BNCC como fruto de posicionamentos políticos, e não apenas o resultado de uma construção coletiva, como o enunciador busca convencer seu enunciatário. Assim, para ancorar nossas discussões, recorremos à Semiótica, de linha francesa, a fim de estudarmos como se projetam e se relacionam os sujeitos da enunciação, enunciador e enunciatário do discurso.
Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart
Authors: Li Huaping , Fan Jiahui , Zhao Yanru , Zhang Xiaorong , Dai Beibei , Zhan Jiabing , Yin Zhongwei , Nie Xiang , Fu Xiang-Dong , Chen Chen , Wang Dao Wen 
Published: October 2019

Rationale:
Diabetes mellitus is often associated with cardiovascular complications, which is the leading cause of morbidity and mortality among patients with diabetes mellitus, but little is known about the mechanism that connects diabetes mellitus to the development of cardiovascular dysfunction.

Objective:
We aim to elucidate the mechanism underlying hyperglycemia-induced cardiac dysfunction on a well-established db/db mouse model for diabetes mellitus and diabetic complications that lead to heart failure.

Methods and Results:

We first profiled the expression of microRNAs (miRNAs) by microarray and quantitative reverse transcription polymerase chain reaction on db/db mice and identified miR-320 as a key miRNA associated with the disease phenotype. We next established the clinical relevance of this finding by showing the upregulation of the same miRNA in the failing heart of patients with diabetes mellitus. We demonstrated the causal role of miR-320 in inducing diabetic cardiomyopathy, showing that miR-320 overexpression exacerbated while its inhibition improved the cardiac phenotype in db/db mice. Unexpectedly, we found that miR-320 acts as a small activating RNA in the nucleus at the level of transcription. By chromatin immunoprecipitation sequencing and chromatin immunoprecipitation quantitive polymerase chain reaction analysis of Ago2 (argonaute RISC catalytic component 2) and RNA polymerase II in response to miR-320 induction, we identified
CD36
(fatty acid translocase) as a key target gene for this miRNA and showed that the induced expression of CD36 is responsible for increased fatty acid uptake, thereby causing lipotoxicity in the heart.

Conclusions:
These findings uncover a novel mechanism for diabetes mellitus–triggered cardiac dysfunction, provide an endogenous case for small activating RNA that has been demonstrated to date only with synthetic RNAs in transfected cells, and suggest a potential strategy to develop a miRNA-based therapy to treat diabetes mellitus–associated cardiovascular complications.
Intensive Blood Pressure Treatment Reduced Stroke Risk in Patients With Albuminuria in the SPRINT Trial
Authors: Leitão Lia , Soares-dos-Reis Ricardo , Neves João Sérgio , Baptista Rute Baeta , Bigotte Vieira Miguel , Mc Causland Finnian R. 
Published: October 2019

Background and Purpose—
Albuminuria is associated with stroke risk among individuals with diabetes. However, the association of albuminuria with incident stroke among nondiabetic patients is less clear.

Methods—
We performed a post hoc analysis of the SPRINT (Systolic Blood Pressure Intervention Trial), which examined the effect of higher versus lower intensity blood pressure management on mortality in 8913 participants without diabetes. We fit unadjusted and adjusted Cox proportional hazards models to estimate the association of baseline albuminuria (urinary albumin-to-creatinine ratio ≥30 mg/g versus<30 mg/g) with stroke risk. We also assessed effect modification according to treatment arms.

Results—

Mean age was 68±9 years, 35% were female, and 30% were black. Median follow-up was 3.2 years, and 19% patients had baseline albuminuria. Incident stroke occurred in 129 individuals during follow-up. Albuminuria was associated with increased stroke risk (unadjusted hazard ratio, 2.24; 95% CI, 1.55–3.23; adjusted hazard ratio 1.73; 95% CI, 1.17–2.56). The association of albuminuria with incident stroke differed according to the randomized treatment arm (
P
interaction=0.03). In the intensive treatment arm, the association of albuminuria and stroke was nonsignificant (unadjusted hazard ratio, 1.25; 95% CI, 0.69–2.28), whereas, in the standard treatment arm, it was significant (unadjusted hazard ratio, 3.44; 95% CI, 2.11–5.61).

Conclusions—
In a post hoc analysis of SPRINT, baseline albuminuria (versus not) was associated with a higher risk of incident stroke, but this relationship appeared to be restricted to those in the standard treatment arm. Further studies are required to conclusively determine if reduction of albuminuria in itself is beneficial in reducing stroke risk.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01206062.
Apokatastasis as “Twin Mission”: Understanding the Concurrence of the Universality and Particularity of Logos and Ruach in the Economy of Salvation
Authors: Sivasubramanian David Muthukumar 
Published: October 2019

Abstract
Universal salvation (apokatastasis), once considered as an anathema, has recently gained a lot of currency in theological reflections. This paper will attempt to explore the possibilities for such a universal restitution of all creation using Irenaeus’ conception of the double mission of the Son and the Spirit in relation to creation as “the two hands with which God creates and perfects.” Toward this purpose, it will try to address the inherent limitations within the traditional notion of conceiving Christ as the Redeemer and the Spirit as the Sanctifier that has often resulted in a binary understanding of the role of Christ as “objective” and that of the Spirit as “subjective.” It will argue for a complementary understanding of the “twin mission” through a dialectical-chiastic pattern that will balance the subjective-objective and particular-universal aspects of the Logos and the Ruach.
Verification Results from the 2017 HMT–WPC Flash Flood and Intense Rainfall Experiment
Authors: Erickson Michael J. , Kastman Joshua S. , Albright Benjamin , Perfater Sarah , Nelson James A. , Schumacher Russ S. , Herman Gregory R. 
Published: October 2019

AbstractThe Flash Flood and Intense Rainfall (FFaIR) Experiment developed within the Hydrometeorology Testbed (HMT) of the Weather Prediction Center (WPC) is a pseudo-operational platform for participants from across the weather enterprise to test emerging flash flood forecasting tools and issue experimental forecast products. This study presents the objective verification portion of the 2017 edition of the experiment, which examines the performance from a variety of guidance tools (deterministic models, ensembles, and machine-learning techniques) and the participants’ forecasts, with occasional reference to the participants’ subjective ratings. The skill of the model guidance used in the FFaIR Experiment is evaluated using performance diagrams verified against the Stage IV analysis. The operational and FFaIR Experiment versions of the excessive rainfall outlook (ERO) are evaluated by assessing the frequency of issuances, probabilistic calibration, Brier skill score (BSS), and area under relative operating characteristic (AuROC). An ERO first-guess field called the Colorado State University Machine-Learning Probabilities method (CSU-MLP) is also evaluated in the FFaIR Experiment. Among convection-allowing models, the Met Office Unified Model generally performed optimally throughout the FFaIR Experiment when using performance diagrams (at the 0.5- and 1-in. thresholds; 1 in. = 25.4 mm), whereas the High-Resolution Rapid Refresh (HRRR), version 3, performed best subjectively. In terms of subjective and objective ensemble scores, the HRRR ensemble scored optimally. The CSU-MLP overpredicted lower risk categories and underpredicted higher risk categories, but it shows future promise as an ERO first-guess field. The EROs issued by the FFaIR Experiment forecasters had improved BSS and AuROC relative to the operational ERO, suggesting that the experimental guidance may have aided forecasters.
Fundamental Behavior of ENSO Phase Locking
Authors: Chen Han-Ching , Jin Fei-Fei 
Published: October 2019

AbstractEl Niño–Southern Oscillation (ENSO) events tend to peak at the end of the calendar year, a phenomenon called ENSO phase locking. This phase locking is a fundamental ENSO property that is determined by its basic dynamics. The conceptual ENSO recharge oscillator (RO) model is adopted to examine the ENSO phase-locking behavior in terms of its peak time, strength of phase locking, and asymmetry between El Niño and La Niña events. The RO model reproduces the main phase-locking characteristics found in observations, and the results show that the phase locking of ENSO is mainly dominated by the seasonal modulation of ENSO growth/decay rate. In addition, the linear/nonlinear mechanism of ENSO phase preference/phase locking is investigated using RO model. The difference between the nonlinear phase-locking mechanism and linear phase-preference mechanism is largely smoothed out in the presence of noise forcing. Further, the impact on ENSO phase locking from annual cycle modulation of the growth/decay rate, stochastic forcing, nonlinearity, and linear frequency are examined in the RO model. The preferred month of ENSO peak time depends critically on the phase and strength of the seasonal modulation of the ENSO growth/decay rate. Furthermore, the strength of phase locking is mainly controlled by the linear growth/decay rate, the amplitude of seasonal modulation of growth/decay rate, the amplitude of noise, the SST-dependent factor of multiplicative noise, and the linear frequency. The asymmetry of the sharpness of ENSO phase locking is induced by the asymmetric effect of state-dependent noise forcing in El Niño and La Niña events.
On the Superposition of Mean Advective and Eddy-Induced Transports in Global Ocean Heat and Salt Budgets
Authors: Dias Fabio Boeira , Domingues C. M. , Marsland S. J. , Griffies S. M. , Rintoul S. R. , Matear R. , Fiedler R. 
Published: October 2019

AbstractOcean thermal expansion is a large contributor to observed sea level rise, which is expected to continue into the future. However, large uncertainties exist in sea level projections among climate models, partially due to intermodel differences in ocean heat uptake and redistribution of buoyancy. Here, the mechanisms of vertical ocean heat and salt transport are investigated in quasi-steady-state model simulations using the Australian Community Climate and Earth-System Simulator Ocean Model (ACCESS-OM2). New insights into the net effect of key physical processes are gained within the superresidual transport (SRT) framework. In this framework, vertical tracer transport is dominated by downward fluxes associated with the large-scale ocean circulation and upward fluxes induced by mesoscale eddies, with two distinct physical regimes. In the upper ocean, where high-latitude water masses are formed by mixed layer processes, through cooling or salinification, the SRT counteracts those processes by transporting heat and salt downward. In contrast, in the ocean interior, the SRT opposes dianeutral diffusion via upward fluxes of heat and salt, with about 60% of the vertical heat transport occurring in the Southern Ocean. Overall, the SRT is largely responsible for removing newly formed water masses from the mixed layer into the ocean interior, where they are eroded by dianeutral diffusion. Unlike the classical advective–diffusive balance, dianeutral diffusion is bottom intensified above rough bottom topography, allowing an overturning cell to develop in alignment with recent theories. Implications are discussed for understanding the role of vertical tracer transport on the simulation of ocean climate and sea level.
Assessment of the Sea Surface Temperature Predictability Based on Multimodel Hindcasts
Authors: Zhang Shouwen , Jiang Hua , Wang Hui 
Published: October 2019

Abstract
Based on historical forecasts of four individual forecasting systems, we conducted multimodel ensembles (MME) to predict the sea surface temperature anomaly (SSTA) variability and assessed these methods from a deterministic and probabilistic point of view. To investigate the advantages and drawbacks of different deterministic MME methods, we used simple averaged MME with equal weighs (SCM) and the stepwise pattern projection method (SPPM). We measured the probabilistic forecast accuracy by Brier skill score (BSS) combined with its two components: reliability (Brel) and resolution (Bres). The results indicated that SCM showed a high predictability in the tropical Pacific Ocean, with a correlation exceeding 0.8 with a 6-month lead time. In general, the SCM outperformed the SPPM in the tropics, while the SPPM tend to show some positive effect on the correction when at long lead times. Corrections occurred for the spring predictability barrier of ENSO, in particular for improvements when the correlation was low or the RMSE was large using the SCM method. These qualitative results are not susceptible to the selection of the hindcast periods, it is as a rule rather by chance of these individual systems. Performance of our probabilistic MME was better than the Climate Forecast System version2 (CFSv2) forecasts in forecasting COLD, NEUTRAL, and WARM SSTA categories for most regions, mainly due to the contribution of Brel, indicating more adequate ensemble construction strategies of the MME system superior to the CFSv2.
Tornado Fatalities: An Environmental Perspective
Authors: Anderson-Frey Alexandra K. , Brooks Harold 
Published: October 2019

Abstract
Deadly tornadoes are rare events, but that level of rarity varies with many factors. In this work, we summarize and update past research on tornado fatalities, and also discuss the environments of deadly tornadoes both from the perspective of proximity soundings (i.e., point-based) and self-organizing maps (i.e., two-dimensional). In our study of 16 232 tornado events from 2003 to 2017, we find that deadly tornadoes are disproportionately likely to have high (E)F-scale ratings, to have right-moving supercell parent storm modes (deadly QLCS tornadoes are exceptionally rare and tend to result in only one death when they do occur), and to occur during the winter and spring. Warning skill is generally higher for deadly tornadoes than for nondeadly tornadoes: 87% of deadly tornadoes were warned in advance, and nearly 95% of tornado deaths occurred within an active warning. The same environments are warned well for both deadly and nondeadly tornadoes, but the deadly tornadoes tend to occur in environments that are less conducive to weaker (E)F0–1 tornadoes. We identify four prototypical deadly tornado scenarios using self-organizing maps, ranging from marginal environments resulting in relatively few fatalities to major deadly outbreak events. Overall results indicate that the most dangerous tornadoes (i.e., those with high numbers of deaths per deadly tornado) also generally occur in environments and under conditions in which warning skill is high. While, generally speaking, the correct storms are being warned, we include some recommendations for additional research and further improvement.
Factors Influencing the Performance of Regression-Based Statistical Postprocessing Models for Short-Term Precipitation Forecasts
Authors: Li Wentao , Duan Qingyun , Wang Quan J. 
Published: October 2019

Abstract
Statistical postprocessing models can be used to correct bias and dispersion errors in raw precipitation forecasts from numerical weather prediction models. In this study, we conducted experiments to investigate four factors that influence the performance of regression-based postprocessing models with normalization transformations for short-term precipitation forecasts. The factors are 1) normalization transformations, 2) incorporation of ensemble spread as a predictor in the model, 3) objective function for parameter inference, and 4) two postprocessing schemes, including distributional regression and joint probability models. The experiments on the first three factors are based on variants of a censored regression model with conditional heteroscedasticity (CRCH). For the fourth factor, we compared CRCH as an example of the distributional regression with a joint probability model. The results show that the CRCH with normal quantile transformation (NQT) or power transformation performs better than the CRCH with log–sinh transformation for most of the subbasins in Huai River basin with a subhumid climate. The incorporation of ensemble spread as a predictor in CRCH models can improve forecast skill in our research region at short lead times. The influence of different objective functions (minimum continuous ranked probability score or maximum likelihood) on postprocessed results is limited to a few relatively dry subbasins in the research region. Both the distributional regression and the joint probability models have their advantages, and they are both able to achieve reliable and skillful forecasts.
Surgical Management of Vestibular Schwannoma: Practice Pattern Analysis via NSQIP
Authors: Patel Vijay A. , Dunklebarger Mitchell , Banerjee Kalins , Shokri Tom , Zhan Xiang , Isildak Huseyin 
Published: October 2019

Objective:Characterize current perspectives in the surgical management of vestibular schwannoma (VS) to guide otolaryngologists in understanding United States practice patterns.Methods:A retrospective analysis of ACS-NSQIP database was performed to abstract all patients from 2008 to 2016 who underwent VS resection using ICD-9/10 codes 225.1 and D33.3, respectively. The specific surgical approach employed was identified via CPT codes 61520, 61526/61596, and 61591, which represent retrosigmoid (RS), translabyrinthine (TL) and middle cranial fossa (MCF) approaches, respectively. Analyzed outcomes include general surgical complications, total length of stay, and reoperation.Results:A total of 1671 VS cases were identified, 1266 (75.7%) were RS, 292 (17.5%) were TL, and 114 (6.8%) were MCF. The annual number of cases increased over the study period from 15 to 375, which is chiefly attributed to increased institutional participation in ACS-NSQIP. Perioperative variables including BMI ( P < .001), ASA class ( P = .004), ethnicity ( P = .008), operative time ( P < .001), and reoperation ( P < .001) were found to be statistically significant between cohorts. Increased utilization of RS approach was consistent over the entire study period, with significantly more RS performed than either TL or MCF. Finally, a statistically significant difference with respect to general surgical complication rates was not noted between surgical approaches.Conclusions:There is increased employment of RS approach for the operative management of VS, which likely is the result of increased reliance on both stereotactic radiosurgery and observation as alternative treatment strategies.
Association between FSAP 1601G>A polymorphism and venous thromboembolism risk: A meta-analysis
Authors: Da Li , Jiahui Zhao , Xiaoqiang Li 
Published: October 2019

Objective Previous several studies have shown that factor VII-activating protease (FSAP) gene 1601G>A polymorphism is related to the occurrence of venous thromboembolism, but the results are inconsistent and controversial. Therefore, we conducted a meta-analysis to explore the association between FSAP 1601G>A polymorphism and venous thromboembolism susceptibility. Methods We managed a systematic literature search through Pubmed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases to collect research data related to FSAP gene 1601G>A polymorphism and susceptibility to venous thromboembolism published before May 2019. Data analysis was performed through Revman 5.3 and Stata 12.0 software, the pooled odd ratios and 95% confidence intervals were calculated. Additionally, the sensitivity analysis and publication bias assessment were also performed. Results A total of seven case–control studies were included and evaluated, including 2411 venous thromboembolism cases and 2850 controls. The meta-analysis results revealed that the FSAP 1601G>A mutation is associated with venous thromboembolism risk, and statistically significance was observed under three genetic comparison models (A: G, odds ratio: 1.33, 95% confidence interval: 1.07–1.66; GA: GG, odds ratio: 1.34, 95% confidence interval: 1.06–1.68; and GA + AA: GG, odds ratio: 1.33, 95% confidence interval: 1.06–1.66). Conclusion This study demonstrated that the FSAP 1601G>A polymorphism may be associated with venous thromboembolism susceptibility.
Recurrent activity-induced headache associated with posttraumatic dural adhesion of the middle meningeal artery: A case report
Authors: Elisevich Lee , Singer Justin , Walsh Meggen 
Published: October 2019

Background The middle meningeal artery is surrounded by a plexus of afferent fibers shown to be involved in the progression of some forms of headache, especially migraine. Posttraumatic headache disorders sharing characteristics with migraine and involving the middle meningeal artery are not readily available in the literature. Case description This report describes a posttraumatic headache disorder in a middle-aged woman in which the causative factor proved to be a pathology of the left middle meningeal artery that resulted from trauma. Her pain could be triggered by moderate accelerative changes, occurring in the left frontotemporal region, and shared characteristics with migraine. Resection of a portion of the left middle meningeal artery has completely eliminated her pain syndrome. Conclusion This case further elucidates associations between the middle meningeal artery and headache. The presentation of posttraumatic headache sharing characteristics with migraine should suggest the possibility of a middle meningeal artery abnormality.