bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypnotherapy for Irritable Bowel Syndrome-Type Symptoms in Patients with Quiescent Inflammatory Bowel Disease: A Randomized, Controlled Trial
Authors: Hoekman Daniël R , Vlieger Arine M , Stokkers Pieter C , Mahhmod Nofel , Rietdijk Svend , de Boer Nanne K , de Meij Tim G , Frankenhuis Carla , D’Haens Geert R , Benninga Marc A 
Published: November 2020

Abstract

Background and Aims
Many inflammatory bowel disease [IBD] patients in remission have persisting symptoms, compatible with irritable bowel syndrome [IBS-type symptoms]. We aimed to compare the effectiveness of gut-directed hypnotherapy vs standard medical treatment [SMT] for IBS-type symptoms in IBD patients.

Methods
In this multicentre, randomized, controlled, open-label trial, patients aged 12–65 years with IBD in clinical remission [global assessment] and biochemical remission [faecal calprotectin ≤100 µg/g, or ≤200 µg/g without inflammation at endoscopy] with IBS according to Rome III criteria were randomized to hypnotherapy or SMT. Primary outcome was the proportion with ≥50% reduction on a visual analog scale for symptom severity, as measured with the Irritable Bowel Syndrome Severity Scoring System [IBS-SSS] at week 40 [i.e. 6 months after finishing the intervention], compared to baseline. Secondary outcomes included total IBS-SSS score, quality of life, adequate relief, IBS-related cognitions, and depression and anxiety scores.

Results
Eighty patients were included, of whom 70 received at least one session of the allocated treatment and were included in the modified intention-to-treat-population. Seven patients were excluded because of missing baseline data required for the primary outcome. The primary outcome was met in nine [27%] of 33 patients randomized to SMT and nine [30%] of 30 patients randomized to hypnotherapy [p = 0.81]. Adequate relief was reported in 60% and 40% of subjects, respectively. Exploratory analyses of secondary outcomes revealed no apparent differences between the two treatment groups.

Conclusions
Hypnotherapy was not superior to SMT in the treatment of IBS-type symptoms in IBD patients. Both treatment strategies are reasonable options from a clinical perspective.
Parenthood and the Gender Gap in Workplace Authority
Authors: Stojmenovska Dragana , England Paula 
Published: November 2020

AbstractThis article answers several related questions: does parenthood affect whether women hold positions of authority? Is there a parenthood effect on authority for men? Is the gender gap in authority explained by a more deleterious effect of parenthood on women’s in comparison to men’s representation in positions of authority? Past studies of the relationship between parenthood and workplace authority have been limited in their ability to assess a causal effect of parenthood because most have employed a static approach, measuring the presence of children and the type of job held concurrently, using cross-sectional data. Using retrospective life course data from four rounds of the Family Survey of the Dutch Population and distributed fixed-effects models, we study within-person changes in having supervisory authority among women and men in the years before, around, and after the birth of their first child. The findings show a moderate negative effect of motherhood on women’s representation in authority, which is entirely explained by a reduction in the number of hours worked. Fatherhood has no effect on men’s representation in authority. The gender gap in supervisory authority between women and men grows over time but is already very large years before the transition to first-time parenthood.
COVID-19, a tale of two pandemics: novel coronavirus and fake news messaging
Authors: Atehortua Nelson A , Patino Stella 
Published: November 2020

Summary
The emergence of COVID-19, caused by novel Coronavirus SARS-CoV-2, became a pandemic in just 10 weeks. Without effective medications or vaccines available, authorities turned toward mitigation measures such as use of face masks, school’s closings, shelter-in-place, telework and social distancing. People found refuge on the internet and social media apps; however, there was a proliferation of instant messaging containing hoaxed, deliberate misleading information: fake news messaging (FNM). The aim of this study was to assess FNM through content analysis and to discriminate them in a proposed taxonomy structure. A sample of convenience of messages, memes, tweets or cartoons in several languages was selected from the most popular social media outlets, i.e. Facebook, WhatsApp, Twitter etc. More than 300 FNM were identified. Descriptive statistics were used for highlighting potential relationships between variables. Content analysis determined that FNM could be divided into Health- and non-health-related types. There are several sub-types considering, but not limited to, religious beliefs, politics, economy, nutrition, behaviors, prevention of the infection, the origin of the disease and conspiracy theories. The parallel FNM pandemic affected the response from an already debilitated public health system through the confusion created in the community and the erosion in the credibility of genuine media. Public health practitioners had to face people’s unpredictable behaviors, panic, tensions with the communities and, in some cases, a hostile climate toward frontline workers. Public health practitioners must adjust ongoing and future health promotion and education interventions including plans to neutralize fake news messages.
MSH2knock-down shows CTG repeat stability and concomitant upstream demethylation at theDMPKlocus in myotonic dystrophy type 1 human embryonic stem cells
Authors: Franck Silvie , Barbé Lise , Ardui Simon , De Vlaeminck Yannick , Allemeersch Joke , Dziedzicka Dominika , Spits Claudia , Vanroye Fien , Hilven Pierre , Duqué Geoffrey , Vermeesch Joris R , Gheldof Alexander , Sermon Karen 
Published: November 2020

AbstractMyotonic dystrophy type 1 (DM1) is caused by expansion of a CTG repeat in the DMPK gene, where expansion size and somatic mosaicism correlates with disease severity and age of onset. While it is known that the mismatch repair protein MSH2 contributes to the unstable nature of the repeat, its role on other disease-related features, such as CpG methylation upstream of the repeat, is unknown. In this study, we investigated the effect of an MSH2 knock-down (MSH2KD) on both CTG repeat dynamics and CpG methylation pattern in human embryonic stem cells (hESC) carrying the DM1 mutation. Repeat size in MSH2 wild-type (MSH2WT) and MSH2KD DM1 hESC was determined by PacBio sequencing and CpG methylation by bisulfite massive parallel sequencing. We found stabilization of the CTG repeat concurrent with a gradual loss of methylation upstream of the repeat in MSH2KD cells, while the repeat continued to expand and upstream methylation remained unchanged in MSH2WT control lines. Repeat instability was re-established and biased towards expansions upon MSH2 transgenic re-expression in MSH2KD lines while upstream methylation was not consistently re-established. We hypothesize that the hypermethylation at the mutant DM1 locus is promoted by the MMR machinery and sustained by a constant DNA repair response, establishing a potential mechanistic link between CTG repeat instability and upstream CpG methylation. Our work represents a first step towards understanding how epigenetic alterations and repair pathways connect and contribute to the DM1 pathology.
Impacts of shade on cattle well-being in the beef supply chain
Authors: Edwards-Callaway Lily N , Cramer M Caitlin , Cadaret Caitlin N , Bigler Elizabeth J , Engle Terry E , Wagner John J , Clark Daniel L 
Published: November 2020

AbstractShade is a mechanism to reduce heat load providing cattle with an environment supportive of their welfare needs. Although heat stress has been extensively reviewed, researched, and addressed in dairy production systems, it has not been investigated in the same manner in the beef cattle supply chain. Like all animals, beef cattle are susceptible to heat stress if they are unable to dissipate heat during times of elevated ambient temperatures. There are many factors that impact heat stress susceptibility in beef cattle throughout the different supply chain sectors, many of which relate to the production system, that is, availability of shade, microclimate of environment, and nutrition management. The results from studies evaluating the effects of shade on production and welfare are difficult to compare due to variation in structural design, construction materials used, height, shape, and area of shade provided. Additionally, depending on operation location, shade may or may not be beneficial during all times of the year, which can influence the decision to make shade a permanent part of management systems. Shade has been shown to lessen the physiologic response of cattle to heat stress. Shaded cattle exhibit lower respiration rates, body temperatures, and panting scores compared with unshaded cattle in weather that increases the risk of heat stress. Results from studies investigating the provision of shade indicate that cattle seek shade in hot weather. The impact of shade on behavioral patterns is inconsistent in the current body of research, with some studies indicating that shade provision impacts behavior and other studies reporting no difference between shaded and unshaded groups. Analysis of performance and carcass characteristics across feedlot studies demonstrated that shaded cattle had increased ADG, improved feed efficiency, HCW, and dressing percentage when compared with cattle without shade. Despite the documented benefits of shade, current industry statistics, although severely limited in scope, indicate low shade implementation rates in feedlots and data in other supply chain sectors do not exist. Industry guidelines and third-party on-farm certification programs articulate the critical need for protection from extreme weather but are not consistent in providing specific recommendations and requirements. Future efforts should include: updated economic analyses of cost vs. benefit of shade implementation, exploration of producer perspectives and needs relative to shade, consideration of shade impacts in the cow–calf and slaughter plant segments of the supply chain, and integration of indicators of affective (mental) state and preference in research studies to enhance the holistic assessment of cattle welfare.
The impact of body composition on short-term outcomes of neoadjuvant chemotherapy with gemcitabine plus S-1 in patients with resectable pancreatic cancer
Authors: Takeda Tsuyoshi , Sasaki Takashi , Mie Takafumi , Furukawa Takaaki , Yamada Yuto , Kasuga Akiyoshi , Matsuyama Masato , Ozaka Masato , Sasahira Naoki 
Published: November 2020

Abstract

Background
Although the efficacy of neoadjuvant chemotherapy with gemcitabine plus S-1 (NAC GS) has recently been reported in resectable pancreatic cancer, severe adverse events were frequently observed. Sarcopenia has been reported to be associated with reduced antitumor response and chemotherapy toxicity in several malignancies. The aim of this study is to evaluate the impact of body composition on short-term outcomes of NAC GS in resectable pancreatic cancer patients.

Methods
Clinicopathological data of consecutive patients treated with NAC GS at our institution from February 2019 to April 2020 were retrospectively reviewed. Anthropometric variables were calculated at the third lumbar vertebra using pretreatment computed tomography images. We investigated the association between body composition variables, and antitumor response and chemotherapy toxicity.

Results
Among 62 patients included in this study, 25 patients (40%) were sarcopenic at diagnosis. Sixty-one patients received surgery at our institution and 57 patients received pancreatic resection (R0/R1 resection 56/1). Fifty-six patients completed two cycles of NAC GS and severe adverse events (≥grade 3) occurred in 42 patients (hematologic toxicity 41 patients [66%]; non-hematologic toxicity 3 patients). Body mass index and total adipose tissue index were significantly lower in sarcopenic patients compared to non-sarcopenic patients. Completion rate of NAC, rate of treatment delay/interruption, relative dose intensity of gemcitabine and S-1, radiological and pathological tumor response after NAC were not different between sarcopenic and non-sarcopenic patients. Furthermore, there was no significant association between body composition, and severe adverse events and intolerance.

Conclusions
In our experience, NAC GS was similarly tolerable and effective in resectable pancreatic cancer patients regardless of the presence of sarcopenia.
Bi-Directional Associations Between Real-Time Affect and Physical Activity in Weight-Discordant Siblings
Authors: Smith Kathryn E , Mason Tyler B , O’Connor Shannon M , Wang Shirlene , Dzubur Eldin , Crosby Ross D , Wonderlich Stephen A , Salvy Sarah-Jeanne , Feda Denise M , Roemmich James N 
Published: November 2020

Abstract

Pediatric obesity confers increased risk for a host of negative psychological and physical health consequences and is reliably linked to low levels of physical activity. Affective antecedents and consequences of physical activity are thought to be important for the development and maintenance of such behavior, though research examining these associations in youth across the weight spectrum remains limited.

Objective
This study examined bi-directional associations between affect and physical activity (i.e., moderate-to-vigorous physical activity [MVPA] and total activity counts), and the extent to which weight (body mass index z-score [z-BMI]) moderated these associations.

Methods
Participants were drawn from a prior study of siblings (N = 77; mean age = 15.4 ± 1.4 years) discordant for weight status (39 nonoverweight siblings, 38 siblings with overweight/obesity) who completed ecological momentary assessment (EMA) with accelerometer-assessed physical activity.

Results
Generalized linear mixed models indicated z-BMI moderated trait-level and momentary associations. When adolescents with higher z-BMI reported momentary negative affect, they evidenced less MVPA within the next hour. Across the sample, greater overall activity was associated with lower negative affect. However, at the momentary level, when adolescents with higher (but not lower) z-BMI evidenced greater activity, they reported decreases in negative affect.

Conclusions
Findings indicate affective experiences surrounding physical activity differ according to z-BMI. Specifically, momentary negative affect may impede momentary MVPA among youth with higher z-BMI. Further research is warranted to elucidate factors influencing these momentary associations and the extent to which these momentary associations prospectively predict weight change.
Efficacy and tolerability of preoperative chemoradiotherapy with S-1 alone for locally advanced rectal cancer
Authors: Imano Nobuki , Murakami Yuji , Kubo Katsumaro , Kawahara Daisuke , Takeuchi Yuki , Nishibuchi Ikuno , Kimura Tomoki , Kochi Masatoshi , Takakura Yuji , Shimizu Wataru , Egi Hiroyuki , Uegami Shinnosuke , Ohge Hiroki , Takahashi Shinya , Ohdan Hideki , Nagata Yasushi 
Published: November 2020

Abstract
Preoperative chemoradiotherapy with capecitabine or 5-fluorouracil is a standard treatment for locally advanced rectal cancer (LARC). S-1, a prodrug of 5-fluorouracil, is a candidate for this chemoradiotherapy regimen in Japan; however, treatment outcomes after S-1 treatment alone are not clear. This study aimed to assess the efficacy and tolerability of preoperative chemoradiotherapy with S-1 alone for LARC. We retrospectively evaluated 54 LARC patients who underwent preoperative chemoradiotherapy with S-1 alone in our institution between 2005 and 2017. The clinical tumor stage was cT2–3 in 31 patients and cT4 in 23 patients, and lymph node metastases were clinically evident in 31 patients. S-1, at a dose of 80 mg/m2/day, was orally administered during radiotherapy. A total dose of 45–50.4 Gy was delivered in 25–28 fractions (median: 50.4 Gy). Surgical resections were scheduled 6–10 weeks after chemoradiotherapy completion. The 3- and 5-year overall survival rates were 92.4 and 72.8%, respectively, with a median follow-up time of 51 months. The 3- and 5-year local control rates were 96.2 and 85.9%, respectively. A pathological complete response was observed in 7 patients (13.0%) at the time of surgery. Ten patients (18.5%) had grade 3 acute toxicities and 5 patients (9.3%) had grade 3 late toxicities. No grade 4 or 5 toxicities were observed. Preoperative chemoradiotherapy with S-1 alone followed by total mesorectal excision resulted in a low incidence of toxicities and comparable clinical results. Therefore, S-1 alone can be a treatment option for preoperative chemoradiotherapy in LARC patients.
The secrets of calcicole species revealed
Authors: Lux Alexander , Kohanová Jana , White Philip J 
Published: November 2020

This article comments on:
Kotula L, Clode PL, Ranathunge K, Lambers H. 2021. Role of roots in adaptation of soil-indifferent Proteaceae to calcareous soils in south-western Australia. Journal of Experimental Botany 72, 1490–1505.
Probability logic: A model-theoretic perspective
Authors: Pourmahdian M , Zoghifard R 
Published: November 2020

Abstract
This paper provides some model-theoretic analysis for probability (modal) logic ($PL$). It is known that this logic does not enjoy the compactness property. However, by passing into the sublogic of $PL$, namely basic probability logic ($BPL$), it is shown that this logic satisfies the compactness property. Furthermore, by drawing some special attention to some essential model-theoretic properties of $PL$, a version of Lindström characterization theorem is investigated. In fact, it is verified that probability logic has the maximal expressive power among those abstract logics extending $PL$ and satisfying both the filtration and disjoint unions properties. Finally, by alternating the semantics to the finitely additive probability models ($\mathcal{F}\mathcal{P}\mathcal{M}$) and introducing positive sublogic of $PL$ including $BPL$, it is proved that this sublogic possesses the compactness property with respect to $\mathcal{F}\mathcal{P}\mathcal{M}$.
Spin characterization of systematics in CMB surveys – a comprehensive formalism
Authors: McCallum Nialh , Thomas Daniel B , Brown Michael L , Tessore Nicolas 
Published: November 2020

ABSTRACT
The CMB B-mode polarization signal – both the primordial gravitational wave signature and the signal sourced by lensing – is subject to many contaminants from systematic effects. Of particular concern are systematics that result in mixing of signals of different ‘spin’, particularly leakage from the much larger spin-0 intensity signal to the spin-2 polarization signal. We present a general formalism, which can be applied to arbitrary focal plane setups, that characterizes signals in terms of their spin. We provide general expressions to describe how spin-coupled signals observed by the detectors manifest at map-level, in the harmonic domain, and in the power spectra, focusing on the polarization spectra – the signals of interest for upcoming CMB surveys. We demonstrate the presence of a previously unidentified cross-term between the systematic and the intrinsic sky signal in the power spectrum, which in some cases can be the dominant source of contamination. The formalism is not restricted to intensity to polarization leakage but provides a complete elucidation of all leakage including polarization mixing, and applies to both full and partial (masked) sky surveys, thus covering space-based, balloon-borne, and ground-based experiments. Using a pair-differenced setup, we demonstrate the formalism by using it to completely characterize the effects of differential gain and pointing systematics, incorporating both intensity leakage and polarization mixing. We validate our results with full time ordered data simulations. Finally, we show in an Appendix that an extension of simple binning map-making to include additional spin information is capable of removing spin-coupled systematics during the map-making process.
Modelling heterogeneous dust particles: an application to cometary polarization
Authors: Halder Prithish , Ganesh Shashikiran 
Published: November 2020

ABSTRACT
In this work, we introduce a comet dust model that incorporates multiple dust morphologies along with inhomogeneous mixture of silicate minerals and carbonaceous materials under power-law size distribution, to replicate the standard polarization-phase curve observed in several comets in the narrow-band continuum. Following the results from Rosetta/midas and COSIMA, we create high porosity hierarchical aggregates (HA) and low porosity (&lt;10 per cent) Solids in the form of agglomerated debris. We also introduce a moderate porosity structure with solids in the core, surrounded by fluffy aggregates called fluffy solids (FS). We study the mixing combinations, (HA and Solids), (HA and FS), and (HA, FS, and Solids) for a range of power-law index n= 2.0 to 3.0 for different sets of mixing percentage of silicate minerals and carbonaceous materials. Polarimetry of the short period comets 1P/Halley and 67P/Churyumov-Gerasimenko match best with the polarization resulting from the combination of HA and Solids while the combinations (HA and FS) and (HA, FS, and Solids) provide the best-fitting results for the long period comets C/1995 O1 (Hale-Bopp) and C/1996 B2 (Hyakutake). The best-fitting model results also recreate the observed wavelength dependence of polarization. Our dust model agree with the idea that the long period comets may have high percentage of loose particles (HA and FS) compared to those in the case of short period comets as the short period comets experience more frequent and/or higher magnitude of weathering.
Constraints on stupendously large black holes
Authors: Carr Bernard , Kühnel Florian , Visinelli Luca 
Published: November 2020

ABSTRACT
We consider the observational constraints on stupendously large black holes (SLABs) in the mass range $M \gtrsim 10^{11}\, \mathrm{ M_{\odot}}$. These have attracted little attention hitherto, and we are aware of no published constraints on a SLAB population in the range (1012–$10^{18})\, \mathrm{ M_{\odot}}$. However, there is already evidence for black holes of up to nearly $10^{11}\, \mathrm{ M_{\odot}}$ in galactic nuclei, so it is conceivable that SLABs exist and they may even have been seeded by primordial black holes. We focus on limits associated with (i) dynamical and lensing effects, (ii) the generation of background radiation through the accretion of gas during the pre-galactic epoch, and (iii) the gamma-ray emission from the annihilation of the halo of weakly interacting massive particles expected to form around each SLAB if these provide the dark matter. Finally, we comment on the constraints on the mass of ultralight bosons from future measurements of the mass and spin of SLABs.