bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemoradiation-Related Lymphopenia and Its Association with Survival in Patients with Squamous Cell Carcinoma of the Anal Canal
Authors: Lee Grace , Kim Daniel W. , Muralidhar Vinayak , Mitra Devarati , Horick Nora K. , Eyler Christine E. , Hong Theodore S. , Drapek Lorraine C. , Allen Jill N. , Blaszkowsky Lawrence S. , Giantonio Bruce , Parikh Aparna R. , Ryan David P. , Clark Jeffrey W. , Wo Jennifer Y. 
Published: September 2020

Abstract

Background
Although treatment-related lymphopenia (TRL) is common and associated with poorer survival in multiple solid malignancies, few data exist for anal cancer. We evaluated TRL and its association with survival in patients with anal cancer treated with chemoradiation (CRT).

Materials and Methods
A retrospective analysis of 140 patients with nonmetastatic anal squamous cell carcinoma (SCC) treated with definitive CRT was performed. Total lymphocyte counts (TLC) at baseline and monthly intervals up to 12 months after initiating CRT were analyzed. Multivariable Cox regression analysis was performed to evaluate the association between overall survival (OS) and TRL, dichotomized by grade (G)4 TRL (&lt;0.2k/μL) 2 months after initiating CRT. Kaplan-Meier and log-rank tests were used to compare OS between patients with versus without G4 TRL.

Results
Median time of follow-up was 55 months. Prior to CRT, 95% of patients had a normal TLC (&gt;1k/μL). Two months after initiating CRT, there was a median of 71% reduction in TLC from baseline and 84% of patients had TRL: 11% G1, 31% G2, 34% G3, and 8% G4. On multivariable Cox model, G4 TRL at two months was associated with a 3.7-fold increased risk of death. On log-rank test, the 5-year OS rate was 32% in the cohort with G4 TRL versus 86% in the cohort without G4 TRL.

Conclusion
TRL is common and may be another prognostic marker of OS in anal cancer patients treated with CRT. The association between TRL and OS suggests an important role of the host immunity in anal cancer outcomes.

Implications for Practice
This is the first detailed report demonstrating that standard chemoradiation (CRT) commonly results in treatment-related lymphopenia (TRL), which may be associated with a poorer overall survival (OS) in patients with anal squamous cell carcinoma. The association between TRL and worse OS observed in this study supports the importance of host immunity in survival among patients with anal cancer. These findings encourage larger, prospective studies to further investigate TRL, its predictors, and its relationship with survival outcomes. Furthermore, the results of this study support ongoing efforts of clinical trials to investigate the potential role of immunotherapy in anal cancer.
Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large-Scale Data to Inform Therapeutic Directions
Authors: Jardim Denis L. , Millis Sherri Z. , Ross Jeffrey S. , Woo Michelle Sue-Ann , Ali Siraj M. , Kurzrock Razelle 
Published: September 2020

AbstractBackgroundWe describe the landscape of cyclin and interactive gene pathway alterations in 190,247 solid tumors.MethodsUsing comprehensive genomic profiling (315 genes, &gt;500× coverage), samples were analyzed for alterations in activating/sensitizing cyclin genes (CDK4 amplification, CDK6 amplification, CCND1, CCND2, CCND3, CDKN2B [loss], CDKN2A [loss], SMARCB1), hormone genes (estrogen receptor 1 [ESR1], androgen receptor [AR]), and co-alterations in genes leading to cyclin inhibitor therapeutic resistance (RB1 and CCNE1).ResultsAlterations in at least one cyclin activating/sensitizing gene occurred in 24% of malignancies. Tumors that frequently harbored at least one cyclin alteration were brain gliomas (47.1%), esophageal (40.3%) and bladder cancer (37.9%), and mesotheliomas (37.9%). The most frequent alterations included CDKN2A (13.9%) and CDKN2B loss (12.5%). Examples of unique patterns of alterations included CCND1 amplification in breast cancer (17.3%); CDK4 alterations in sarcomas (12%); CCND2 in testicular cancer (23.4%), and SMARCB1 mutations in kidney cancer (3% overall, 90% in malignant rhabdoid tumors). Alterations in resistance genes RB1 and CCNE1 affected 7.2% and 3.6% of samples. Co-occurrence analysis demonstrated a lower likelihood of concomitant versus isolated alterations in cyclin activating/sensitizing and resistance genes (odds ratio [OR], 0.35; p &lt; .001), except in colorectal, cervical, and small intestine cancers. AR and cyclin activating/sensitizing alterations in prostate cancer co-occurred more frequently (vs. AR alterations and wild-type cyclin activating/sensitizing alterations) (OR, 1.79; p &lt; .001) as did ESR1 and cyclin activating/sensitizing alterations in breast (OR, 1.62; p &lt; .001) and cervical cancer (OR, 4.08; p = .04) (vs. ESR1 and cyclin wild-type activating/sensitizing alterations).ConclusionCyclin pathway alterations vary according to tumor type/histology, informing opportunities for targeted therapy, including for rare cancers.Implications for PracticeCyclin pathway genomic abnormalities are frequent in human solid tumors, with substantial variation according to tumor site and histology. Opportunities for targeted therapy emerge with comprehensive profiling of this pathway.
Sarcoma European and Latin American Network (SELNET) Recommendations on Prioritization in Sarcoma Care During the COVID-19 Pandemic
Authors: Martin-Broto Javier , Hindi Nadia , Aguiar Samuel , Badilla-González Ronald , Castro-Oliden Victor , Chacón Matias , Correa-Generoso Raquel , Álava Enrique , Donati Davide María , Eriksson Mikael , Falla-Jimenez Martin , German Gisela , Gobo Silva Maria Leticia , Gouin Francois , Gronchi Alessandro , Haro-Varas Juan Carlos , Jiménez-Brenes Natalia , Kasper Bernd , Lopes de Mello Celso Abdon , Maki Robert , Martínez-Delgado Paula , Martínez-Said Hector , Martinez-Tlahuel Jorge Luis , Morales-Pérez Jose Manuel , Muñoz-Casares Francisco Cristobal , Nakagawa Suely A. , Ortiz-Cruz Eduardo Jose , Palmerini Emanuela , Patel Shreyaskumar , Moura David S. , Stacchiotti Silvia , Sunyach Marie Pierre , Valverde Claudia M. , Waisberg Federico , Blay Jean-Yves 
Published: September 2020

Abstract

Background
The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present here a consensus on prioritizing recommendations across the continuum of sarcoma patient care.

Material and Methods
A total of 125 recommendations were proposed in soft-tissue, bone, and visceral sarcoma care. Recommendations were assigned as higher or lower priority if they cannot or can be postponed at least 2–3 months, respectively. The consensus level for each recommendation was classified as “strongly recommended” (SR) if more than 90% of experts agreed, “recommended” (R) if 75%–90% of experts agreed and “no consensus” (NC) if fewer than 75% agreed. Sarcoma experts from 11 countries within the Sarcoma European-Latin American Network (SELNET) consortium participated, including countries in the Americas and Europe. The European Society for Medical Oncology-Magnitude of clinical benefit scale was applied to systemic-treatment recommendations to support prioritization.

Results
There were 80 SRs, 35 Rs, and 10 NCs among the 125 recommendations issued and completed by 31 multidisciplinary sarcoma experts. The consensus was higher among the 75 higher-priority recommendations (85%, 12%, and 3% for SR, R, and NC, respectively) than in the 50 lower-priority recommendations (32%, 52%, and 16% for SR, R, and NC, respectively).

Conclusion
The consensus on 115 of 125 recommendations indicates a high-level of convergence among experts. The SELNET consensus provides a tool for sarcoma multidisciplinary treatment committees during the COVID-19 outbreak.
Cancer and Risk of COVID-19 Through a General Community Survey
Authors: Lee Karla A. , Ma Wenjie , Sikavi Daniel R. , Drew David A. , Nguyen Long H. , Bowyer Ruth C. E. , Cardoso M. Jorge , Fall Tove , Freidin Maxim B. , Gomez Maria , Graham Mark , Guo Chuan-Guo , Joshi Amit D. , Kwon Sohee , Lo Chun-Han , Lochlainn Mary Ni , Menni Cristina , Murray Benjamin , Mehta Raaj , Song Mingyang , Sudre Carole H. , Bataille Veronique , Varsavsky Thomas , Visconti Alessia , Franks Paul W. , Wolf Jonathan , Steves Claire J. , Ourselin Sebastien , Spector Tim D. , Chan Andrew T. ,   on behalf of the COPE consortium
Published: September 2020

AbstractIndividuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants &gt;65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.
Single-Agent Versus Double-Agent Chemotherapy in Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma: Prospective, Randomized, Multicenter Phase II Clinical Trial
Authors: Zhao Zhenhuan , Wen Yixue , Liao Dongbiao , Miao Jidong , Gui Yan , Cai Hongwei , Chen Yang , Wei Min , Jia Qiang , Tian Honggang , Sun Mingqiang , Zhang Yu , Feng Gang , Du Xiaobo 
Published: September 2020

Abstract

Lessons Learned
The efficacy of single-agent chemotherapy was not significantly different from that of double-agent chemotherapy in concurrent chemoradiotherapy for inoperable esophageal squamous cell carcinoma. Single-agent concurrent chemoradiotherapy had lower gastrointestinal and hematologic toxicity. Overall survival and progression-free survival were not significantly different between single- and double-agent concurrent chemoradiotherapy.

Background
This multicenter, randomized, phase II trial aimed to compare the efficacy and safety of single-agent concurrent chemoradiotherapy using the oral fluoropyrimidine S-1 with those of double-agent concurrent chemoradiotherapy using S-1 and cisplatin in patients with inoperable esophageal squamous cell carcinoma.

Methods
Patients with inoperable esophageal squamous cell carcinoma (clinical stages I to III) were randomly allocated to the single-agent group (S-1) or the double-agent group (S-1/cisplatin). The concurrent intensity-modulated radiation therapy plan was similar for both groups: planning target volume 1.8 Gy/f*30–33f and planning gross target volume of 2 Gy/f*30–33f. The primary outcome measure was the endoscopic complete response rate.

Results
Of the 105 patients randomized, 89 were assessable. The endoscopic complete response rate was 46.9% (23/49) in the single-agent group and 52.5% (21/40) in double-agent group. The median progression-free survival within a median follow-up of 23 months was 20 and 21 months, respectively. The median overall survival was 26 months and not reached, respectively. Grade 3 hematological toxicities occurred in 4.1% and 27.5% of the patients in the single- and the double-agent group, respectively.

Conclusion
Single-agent chemotherapy in concurrent chemoradiotherapy for inoperable esophageal squamous cell carcinoma has good efficacy and safety, thus warranting a phase III trial.
Değişken gecikmeli kısıtlı stokastik kontrol geçiş sistemleri için regülatör problemi
Authors: AĞAYEVA Çerkez 
Published: September 2020

Bu makalede,
doğrusal stokastik denklemler sınıfıyla
ifade olunan geçiş sistemleri ele alınmıştır. Gecikmeli faz ve kontrol
parametreleri içeren diferansiyel denklemler için karesel amaç fonksiyonu olan
optimal kontrol problemi oluşturulmuş ve sağ uç noktasında kısıta sahip olan durum için optimizasyon problemi incelenmiştir. Literatürde
Doğrusal Karesel Regülatör olarak
bilinen ve sabit katsayılı stokastik diferansiyel denklemlerle ifade olunan bu
problemin optimal lığı için yeter ve gerek koşul, maksimum prensibi şeklinde ispatlanmıştır. Bunun yanı sıra geçiş
sistemleri için önemli olan geçiş noktalarının bulunması için karşıtlık
koşulları bulunmuştur. Sonda ise Doğrusal Karesel Regülatör problemleri için önem taşıyan optmal
kontrolün geri dönüşüm şekli
bulunmuştur. Çözümü, Rikkati
denklemleriyle ifade olunan geri
dönüşüm problemi, bu çalışmada değişken gecikmeli stokastik sistemler için
uygulanmıştır.
On Proposals for Introducing Criminal Responsibility for Arbitrators
Authors: Ilichev P. A. , Savranskiy M. Yu. 
Published: September 2020

The paper provides a critical analysis of the draft law on the introduction of certain norms in the Criminal Code of the Russian Federation concerning the criminal responsibility of arbitrators. The authors present a number of arguments regarding the fact that the prerequisites for the introduction of such responsibility in Russia are currently absent, since the issue is not sufficiently theoretically developed. Issues related to determining the legal responsibility of an arbitrator in various legal systems are considered. The authors substantiate the thesis that in the existing conditions other legal instruments for stimulating the proper activity of arbitrators are more effective, a number of which are successfully applied. In addition, the implementation of the initiative in modern conditions may involve costs that exceed the expected result.It is proved that in the case of imposition of responsibility for arbitrators a set of safeguards activities of arbitrators should be simultaneously legislated. Here, the authors propose to establish guarantees of non-interference in professional activities of an arbitrator as well as legal responsibility for obstructing the activities of an arbitrator’s resolution of a particular dispute. The authors suggest that abitritrators be referred to those individuals who are subject to special procedure of criminal proceedings. It is necessary to provide at the legislative level elements of self-regulation associated with the formation of the arbitration bodies who possess significant powers, including regarding the involvement of arbitrators to criminal responsibility.Based on the results of the research, it is concluded that the relevant issues need to be thoroughly and comprehensively worked out and professionally discussed, which may precede possible changes in legislation.
NBN Futures Forum: Social and Economic Benefits of Broadband for Digital Inclusion and Telehealth
Authors: Campbell Leith H , Smith Anthony C. , Brooks Peter 
Published: September 2020

On 18 August 2020, TelSoc hosted the fourth NBN Futures Forum, held online, on the theme of social and economic benefits of broadband. Three speakers discussed various aspects of the topic, including the need for universal digital inclusion, the benefits of healthcare delivery via telehealth, and the actions required of government to support telehealth availability. Discussion following the speeches emphasised the need for universal access to broadband and telehealth services to improve access to health providers and, through education, reduce social inequities and overcome some social determinants of poor health outcomes.
Investigation of morphological and mineralogy characteristics of dust around the lead and zinc mine in Mehdiabad, Yazd, Iran, Using the SEM and XRD analyzes
Authors: Shojaee Barjoee Saeed , Farokhi Hadi , Zarei Mahmoud Abadi Saeed , Sedghi Saeede 
Published: September 2020

Introduction: Dust created by mining activities is one of the most important concerns regarding human health and the environment protection. The aim of this study was to identify the mineralogical and morphological characteristics of dust particles found around the lead and zinc mine of Mehdiabad.
Materials and methods: First of all, dust samples were collected around the mine by installing eight passive marble dust collectors using a combined systematic random method during February, March and April in 2020. Then, using two methods of X-ray diffraction (XRD) and scanning electron mi- croscopy (SEM) mineralogy, shape and distribution of the particles of dust samples were investigated.
Results: The highest frequency of particles with sizes less than 10, 10-60, and 60-100 µm were determined and observed in S1 station in the northwest, and S5 and S2 stations in the southwest of the mine, respectively. The re- sults of SEM analysis revealed that the appearance of dust particles is mostly Spherical, Irregular, Elongated, Prismatic, and Rhombic. The results of XRD analysis showed that the minerals anorthite (Ca (Al2Si2O8)), dolomite (Ca Mg (CO3)2), albite (NaAlSi3O8), calcite (CaCO3), quartz (SiO2) and muscovite(KAl2 (Si3AlO10)) (OH2) have the highest frequency in dust samples.
Conclusion: The findings show that the predominant mineralogical compo- sition of dust particles includes carbonates (dominant mineral: calcite) and silicates (dominant mineral: quartz) which are found in all stations. Thus, dust particles, with high frequency of quartz, have a high potential to result in respiratory diseases in the inhabitants living around the mine.
Validity and Reliability of the Academic Resilience Scale in Undergraduate Students of Ahvaz Universities
Authors: Sodani M , Ghasemi Jobaneh R 
Published: September 2020

Introduction: Given the importance of academic resilience in students' academic life, the aim of this study was the validity and reliability of the academic resilience scale in undergraduate students of Ahvaz universities.
Methods: in this descriptive psychometric study, the number of 306 undergraduate students from Ahvaz universities (Jundishapur University of Medical Sciences, Shahid Chamran University, Islamic azad University) were selected using Voluntary sampling method and responded to the Cassidy Academic resilience Scale and Fredericks et al. Academic Engagement Scale. Reliability using Cronbach's alpha coefficient, Convergent validity using Pearson correlation coefficient, and construct validity using confirmatory factor analysis were calculated.The collected data were analyzed using SPSS-23 and AMOS-21 software.
Result: Confirmatory factor analysis demonstrated that the ratio χ2/df is 1.89 for three factor structure and fit indexes of model were satisfactory and reasonable. Reliability according to Cronbach's alpha coefficient for Academic resilience Scale was reported 0.85 (perseverance = 0.75, reflecting and adaptive help-seeking= 0.76, negative affect and emotional response= 0.78). There is also a positive and significant correlation between academic resilience and Academic Engagement and Convergent validity is confirmed (r= 0.35).
Conclusion: According to the results of current research, the Academic resilience Scale is a reliable instrument with valid psychometric properties to measure Academic Adjustment in Iranian students and students with lower academic resilience can be identified And take appropriate psychological measures for them.
The Role of Hospital Service Quality and Informing System in Patients' Willingness to Pay with Mediation of Satisfaction
Authors: Zarei Ghasem , Ghorbani Ardahaei Hajieh 
Published: September 2020

Background: The willingness to pay is criteria criterion for measuring the patients' interest to continue their relationship with health centers. The main purpose of this study was to determine the effect of service quality and informing system of hospitals on the patient's willingness to pay with mediating role of patient satisfaction.
Methods: This is an applied survey. The statistical population of this study consisted of all patients referring to Imam Khomeini Hospital in Sarab City during the first six months of 2019. Random sampling method was applied and 390 questionnaires were distributed among the patients. Data gathering tools included researcher made questionnaire with confirmed validity and reliability. Experts’ opinion and confirmatory factor analysis were used to confirm the validity. Cronbach's alpha method and combined reliability coefficient were used for reliability. Data were analyzed using structural equation modeling (SEM) test by partial least squares method. To analyze the data, SPSS 20 and Smart PLS 3 software were used.
Results: Among the distributed questionnaires, 300 ones were completed and returned. According to the descriptive statistics, mean score of service quality, hospital information system, patient satisfaction, and willingness to pay were 2.98, 2.81, 3.44, and 2.67, respectively. The results obtained from the inferential analysis showed that the quality of services had a significant effect on patients’ satisfaction and willingness to pay. Moreover, the information system had a significant effect on patients’ satisfaction and patients' satisfaction had a significant effect on the willingness to pay. The impact of the information system on the willingness to pay was not confirmed.
Conclusion: Based on the findings, changes in the quality of hospital informing system and service quality with the mediating role of patients’ satisfaction affected their willingness to pay.
DIVERSIDADE DE ARTRÓPODES DA FAUNA EDÁFICA EM AGROECOSSISTEMA DE MANDIOCA NO MUNICÍPIO DE CAMETÁ, PARÁ
Authors: Guimarães Eguinaldo Dos Santos , Silva Vandira Sousa da , Padinha Luciane Da Silva , Tavares Dionéa De Carvalho , Silva Luíza Meireles da , Fayal Jardiane De Moraes , Gonçalves Simone Araújo , Cruz Vanessa David 
Published: September 2020

Cultivo de mandioca é característico da Amazônia, onde, seu modo peculiar de implantação, com a presença constante de artrópodes, possibilita o avanço de estudos nestas áreas, principalmente devido ao fato destes organismos serem bioindicadores. Este trabalho tem por objetivo determinar a diversidade de artrópodes em cultivo de mandioca. A pesquisa foi realizada no município de Cametá-PA, entre os meses de janeiro a maio de 2018 por meio de amostragens dos artrópodes, triagem e posterior tratamento estatístico com o software Past 3.20. Foram coletados 945 indivíduos, sendo as ordens Coleoptera e Orthoptera com maior riqueza de espécies. Os índices de diversidades se apresentaram altos, denotando uma área com equilíbrio ecológico, permitindo concluir que fatores como diversidade de plantas adventícias e diversidade no entorno influenciaram os índices. PALAVRAS-CHAVE: Agricultura familiar, Artropodofauna, Índices ecológicos.