bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explorations of Engagement: Introduction
Authors: Bergqvist Henrik , Knuchel Dominique 
Published: February 2020

AbstractThe paper explores engagement as a linguistic category by discussing its defining characteristics. Following work by Evans and colleagues (2018a, b), we discuss issues of scope and the intersubjective distribution of information, as central to the definition of engagement. In addition, we examine the notion of access as a crucial component of engagement marking and we attempt to distinguish access from epistemic authority, which we argue is a prerequisite for the existence of engagement as a linguistic category. Both access and epistemic authority appear central to an analysis of engagement marking, as found in the literature and in the languages of this Special Issue. From an interactional point of view, engagement may be viewed as a form of “stance” (Du Bois 2007), in that it primarily positions the speech participants with respect to talked about events from the point of view of the speaker.
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability
Authors: Busti Irene , Allegra Manuela , Spalletti Cristina , Panzi Chiara , Restani Laura , Billuart Pierre , Caleo Matteo 
Published: February 2020

Oligophrenin-1 (Ophn1) encodes a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID) in humans. Loss of function of Ophn1 leads to impairments in the maturation and function of excitatory and inhibitory synapses, causing deficits in synaptic structure, function and plasticity. Epilepsy is a frequent comorbidity in patients with Ophn1-dependent XLID, but the cellular bases of hyperexcitability are poorly understood. Here we report that male mice knock-out (KO) for Ophn1 display hippocampal epileptiform alterations, which are associated with changes in parvalbumin-, somatostatin- and neuropeptide Y-positive interneurons. Because loss of function of Ophn1 is related to enhanced activity of Rho-associated protein kinase (ROCK) and protein kinase A (PKA), we attempted to rescue Ophn1-dependent pathological phenotypes by treatment with the ROCK/PKA inhibitor fasudil. While acute administration of fasudil had no impact on seizure activity, seven weeks of treatment in adulthood were able to correct electrographic, neuroanatomical and synaptic alterations of Ophn1 deficient mice. These data demonstrate that hyperexcitability and the associated changes in GABAergic markers can be rescued at the adult stage in Ophn1-dependent XLID through ROCK/PKA inhibition.SIGNIFICANCE STATEMENTIn this study we demonstrate enhanced seizure propensity and impairments in hippocampal GABAergic circuitry in Ophn1 mouse model of X-linked intellectual disability (XLID). Importantly, the enhanced susceptibility to seizures, accompanied by an alteration of GABAergic markers were rescued by Rho-associated protein kinase (ROCK)/protein kinase A (PKA) inhibitor fasudil, a drug already tested on humans. Because seizures can significantly impact the quality of life of XLID patients, the present data suggest a potential therapeutic pathway to correct alterations in GABAergic networks and dampen pathological hyperexcitability in adults with XLID.
Your Life Is a Fraction of a Journey
Authors: Esparza Ofelia , Ahrens Rosanna Esparza 
Published: February 2020

On March 1, 2019, the Transformative Arts Network at the University of California, Santa Barbara, held a two-day “Art, Activism, and Imagination” symposium. One memorable and infinitely generative part of the symposium came at the start of the second session, which was dedicated to the collaborative work between artists affiliated with the Alliance for California Traditional Arts and the Building Healthy Communities project in Boyle Heights in East Los Angeles. Altar makers Ofelia Esparza (a National Endowment for the Arts Heritage Fellow) and her daughter Rosanna Esparza Ahrens (graphic designer and cofounder of the artist collective Tonalli Studio—A Place of Creative Wellness) began the afternoon with an instructional session on “how to arrive” followed by a presentation about their work as altaristas.
As participants gathered on a verdant lawn next to a peaceful lagoon near the ocean, the altar makers burned sage and spoke about our obligations at a meeting convened on unceded Indigenous land. Rosanna outlined the four-part process that has guided the process of making altars. This consists of (1) arriving with full awareness of ourselves, our ancestors, and the powers of the natural world; (2) connecting fully with the natural and human world; (3) making agreements for collective conduct; and (4) affirming the possibilities produced by our collective practice. This process guided all the subsequent deliberations of the symposium and has informed much of the subsequent work that has emanated from it. One reason for its impact and influence stems from the extraordinary presentation about altar making that Ofelia and Rosanna presented, which enacted the ideals that the four parts of “learning to arrive” envision. With their permission, we reprint here a transcript of part of their inspiring and enlightening presentation.
Relief in Aeolian Environment. The Surface of Nida Settlement
Authors: Pilkauskas Mindaugas , Piličiauskas Gytis , Vengalis Rokas 
Published: February 2020

During archaeological investigations in Nida settlement in 1974–1978, 2011–2013 and 2016 a lot of stratigraphic data from considerably wide area was gathered. Based on stratigraphy Neolithic paleosol of Nida settlement can be distinguished and it can be used as proxy for reconstruction of paleorelief. Paleosol was recorded in former depressions or on eastward slopes of former dunes. Large area in western part of the settlement was affected by aeolian processes where paleosol did not survive and in the eastern part former surface plunge deeply under groundwater level, these limited the territory considerably for paleorelief reconstruction. Analysis of the paleosol and stratigraphy displayed layering of artefacts in some parts of the settlement, which was interpreted as at least two periods of human activity. Also, in some parts of Nida very thick layer (> 1 m) with artefacts have been recorded which formed because of combination of anthropogenic activity and natural processes. An important insight is made about ancient topographic location of Nida settlement. Based on geological, botanical and geophysical data from Nida and other parts of Curonian spit we argue that earlier interpretation is not supported by recent data and we suggest that Nida settlement was in eastern part of the spit, on the shore of Curonian lagoon.
STUDI IN SILICO: PREDIKSI PENGARUH MUTASI TITIK GEN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR2) TERHADAP STRUKTUR SEKUNDER PROTEIN
Authors: Karina Karina , Rosadi Imam , Rosliana Iis , Wahyuningsih Komang A. 
Published: February 2020

Angiogenesis merupakan proses penting untuk pertumbuhan dan regenerasi sel. Salah satu protein yang berperan dalam angiogenesis adalah vascular endothelial growth factor (VEGF). VEGF akan berinteraksi dengan reseptornya seperti vascular endothelial growth factor receptor-2 (VEGFR2) untuk meregulasi proses angiogenesis. Mutasi pada gen VEGFR2 pada manusia dilaporkan dapat menyebabkan penyakit strawberry mark (hemangioma). Oleh karena itu, perlu dilakukan studi dan penelusuran terkait mutasi yang berperan dalam terbentuknya hemangioma. Beberapa tahapan yang dilakukan untuk menganalisis pengaruh mutasi tersebut diantaranya dengan melakukan penelusuran informasi dasar dan komposisi gen VEGFR2, analisis ortolog dan paralog gen VEGFR2, dan analisis struktur sekunder protein VEGFR2 manusia. Hasilnya menunjukkan bahwa mutasi VEGFR2 pada basa ke-3741 yaitu sitosin (C) menjadi timin (T) dilaporkan ditemukan pada jaringan tumor hemangioma. Perubahan basa ke-3741 sitosin menjadi timin mengakibatkan perubahan asam amino prolin menjadi serin yang dapat berdampak pada regulasi ekspresi VEGF. Ortolog dan paralog dari gen VEGFR2 manusia adalah gen VEGFR2 mencit dan gen fibroblast growth factor receptor 1 (FGFR1) manusia. Hasil analisis pengaruh mutasi terhadap bentuk dan struktur protein menunjukkan tidak ada perubahan yang signifikan, namun posisi mutasi di bagian ekstraseluler sel diduga mempengaruhi regulasi ekspresi VEGF melalui ikatan ligan-reseptor.
ANTAGONISTIC TEST OF RIAU LOCAL FUNGAL ISOLATES AGAINST SOME PATHOGENIC IN CULTIVATED PLANTS
Authors: Safitri Nia , Martina Atria , Roza Rodesia Mustika 
Published: February 2020

Tanaman budi daya merupakan tanaman yang sering diserang oleh cendawan pathogen, sehingga mengakibatkan penurunan populasi dan produksi tanaman. Pengendalian hayati dengan cendawan antagonis merupakan salah satu metode yang paling efektif dan lebih ramah lingkungan dalam menekan pertumbuhan patogen tanaman. Penelitian ini bertujuan untuk menguji aktivitas antagonis cendawan isolat lokal Riau terhadap beberapa cendawan patogen pada tanaman budi daya. Uji antagonis dilakukan secara in vitro dengan metode dual culture menggunakan lima belas cendawan isolat lokal Riau terhadap Fusarium oxysporum f.sp. lycopersici, Ganoderma philippii, G. boninense, Rigidoporus microporus dan Colletotrichum sansevieria. Hasil penelitian menunjukkan bahwa Trichoderma sp. PNE 4 memiliki aktivitas antagonis tertinggi dan isolat FER C1 serta isolat LLB07 hanya memiliki aktivitas antagonis yang tinggi dalam menekan pertumbuhan cendawan patogen. Trichoderma sp. PNE 4 mampu menghambat pertumbuhan miselium F. oxysporum sebesar 85,30%, G. Philippii (100%), G. boninense (100%), dan C. sansevieria (100%). Isolat FER C1 hanya menghambat R. Microporus (50,39%) dan isolat LLB07 menghambat G. philippii (52,20%). Trichoderma sp. PNE 4 merupakan cendawan uji yang terpilih sebagai cendawan antagonis, karena memiliki kemampuan daya hambat >70%.Abstract Cultivated plants are often attacked by pathogenic fungi resulting in a decline of population and crop production. Biocontrol with antagonistic fungi is one of the most effective and environmentally friendly methods in suppressing the growth of plant pathogens. This study aims to examine the antagonistic activity of local isolates fungi Riau against some pathogenic fungi on cultivated plants. The antagonistic test was performed in vitro by dual culture method using fifteen local isolates fungal Riau against Fusarium oxysporum f.sp. lycopersici, Ganoderma philippii, G. boninense, Rigidoporus microporus and Colletotrichum sansevieria. The results showed that Trichoderma sp. PNE 4 isolate exhibited highest activites and FER C1 and LLB07 isolates exhibited high activities suppressed the growth of the fungal pathogen. Trichoderma sp. PNE 4 isolate inhibited mycelial growth F. oxysporum (85.30%), G. philippii (100%), G. boninense (100%) and C. sansevieria (100%). FER C1 isolate only inhibited R. microporus (50.39%), and LLB07 isolate inhibited G. philippii (52.20%). Trichoderma sp. PNE 4 isolate is test isolates as fungal antagonistic.
A brief review of data-driven ICME for intelligently discovering advanced structural metal materials: Insight into atomic and electronic building blocks
Authors: Wang William Yi , Tang Bin , Lin Deye , Zou Chengxiong , Zhang Ying , Shang Shun-Li , Guan Quanmei , Gao Jun , Fan Letian , Kou Hongchao , Song Haifeng , Ma Jijun , Hui Xi-Dong , Gao Michael C. , Liu Zi-Kui , Li Jinshan 
Published: February 2020

Abstract
Representaciones sociales de mujeres en situaciones de violencia doméstica en la asistencia jurídica
Authors: Gomes Iracema Costa Ribeiro , Lira Margaret Olinda de Souza Carvalho , Rodrigues Vanda Palmarella , Vilela Alba Benemérita Alves 
Published: February 2020

Introducción: En el estudio se analizaron las representaciones sociales de las mujeres en situaciones de violencia doméstica que reciben asistencia jurídica. Materiales y Métodos: Investigación cualitativa basada en el enfoque estructural de la Teoría de la Representación Social en donde participaron ochenta mujeres en situaciones de violencia doméstica. La recolección de datos se realizó en el Centro de Apoyo a la Mujer y en la Oficina Especializada de Asistencia a la Mujer ubicada en un municipio de Bahía. Los datos se recopilaron a través de la técnica de asociación libre de palabras y una entrevista semiestructurada. Los datos obtenidos de TALP se analizaron utilizando el software Ensemble des programmes permettant l'analyse des évocations y los datos de la entrevista se organizaron siguiendo la técnica de análisis de contenido. Resultados: El análisis del corpus constituido a partir de los relatos de las 80 mujeres proporcionó 400 palabras cuyo orden promedio fue de tres en promedio en una escala de uno a cinco. Discusión: Las representaciones sociales de las mujeres que reciben asistencia legal muestran, por un lado, que la asistencia legal es lenta, pobre y embarazosa en relación con las demandas de violencia doméstica y, por otro lado, guía, apoya, dirige y da soporte a las mujeres, aunque la necesidad es que sea más efectiva y ágil. Conclusiones: Es necesario reestructurar el poder judicial mediante prácticas más acogedoras, humanizadas y receptivas a las demandas de las mujeres en situaciones de violencia para así superar las prácticas burocráticas y androcéntricas que las hacen vulnerables.
Como citar este artigo: Gomes ICR, Lira MOSC, Rodrigues VP, Vilela AB. Representações sociais de mulheres em situação de violência doméstica sobre assistência jurídica. Rev Cuid. 2020; 11(1): e927. http://dx.doi.org/10.15649/cuidarte.927
The Impact of Sports Activities on the Decrease of PLWHA Stigma and Social Values
Authors: Erida Megia 
Published: February 2020

Sports activities are activities that can be carried out by all groups with the aim of improving the quality of life in terms of physical fitness and psycho-social well-being. People who suffer from HIV/AIDS often get negative stigma and changes in social values. This study was aimed at determining the decrease in stigma and changes in the social value of PLWHA (people with HIV / AIDS) through futsal Rumah Cemara Bandung sports activities. The method used in this study was a comparative causal method (ex-post facto). Design of the study used criteria group. The technique of sampling in this study used convience sampling technique. The sample of this study consisted of 20 people divided into two groups: 10 PLWHA who were active in sports and 10 PLWHA who were not active in sports. Data collection process was conducted through face-to-face interview and structured questionnaire. Based on validity and reliability tests, researchers used an adopted questionnaire and discussed the questionnaire with the expert. Data analysis was conducted by using SPSS version 23 employing independent sample T-test. The results of this study indicate a decrease in stigma and changes in social values seen from T test with tcount ttable. The conclusions from the Stigma calculation was 3.439 2.10092 and Social Value was 3.730 2.10092. The result concludes that sports activities have an effect on reducing the stigma and changes in the Social Value of PLWHA.
Antimicrobial prescribing pattern in a tertiary care teaching hospital: a pilot study
Authors: Rajopadhye Bhagyashri D. , Palkar Sonali H. , Pandit Vijaya A. , Dhande Priti P. , Kumar Mahadevan , Lalwani Sanjay K. 
Published: February 2020

Background: The emergence of antimicrobial resistance is a worldwide challenge threatening to negate the gains made by discovery of antimicrobial agents (AMAs). Antimicrobial Stewardship Program (ASP) is an important strategy for ensuring appropriate use of AMAs and controlling emergence of antibiotic resistance. Implementation of ASP must start with assessment of the current state of antimicrobial use. This study was therefore conducted to assess the prevalent prescribing patterns in a tertiary care hospital and identify gaps which warrant corrective intervention.Methods: This prospective pilot study presents analysis of the first 30 Patients from the medicine ward prescribed at least one antimicrobial agent during the two months of study period. Relevant data was collected in AMA record form. Appropriateness of AMAs was analyzed regarding selection as well as administration protocol as per the hospital antibiotic policy.Results: Out of the 60 AMAs prescribed to these patients, most commonly prescribed were cephalosporins (63.3%), anti-amoebics (26.6%) and macrolides (23.3%). Common diseases involved were urinary tract infection, acute gastroenteritis, sepsis and lower respiratory tract infections. Use of AMAs was found to be appropriate for the indication in 42 %, dose in 97%, duration 60 %, route 93% and frequency 90 %.Conclusions: This gap between the appropriate and the actual practice use of AMAs indicates an urgent need of rigorous implementation of ASP in order to avoid emergence of resistance and to conserve the sensitivity to the available AMAs.
Early surgical management in pancreatic ascites on a background of chronic pancreatitis
Authors: Muthukumarasamy Thiruvarul , Sachanandani Kanchan Ashok , Harikrishnan Sakhtivel , Satyanesan Jeswanth 
Published: February 2020

Background: Pancreatic ascites can occur as a complication of acute or chronic pancreatitis. In majority of cases, it is associated with pseudocyst or duct disruption. Management is initially conservative with paracentesis with nutritional support. Early surgery has been recently contemplated as primary management for pancreatic ascites.Methods: A prospective study was done over a duration of three years from November 2017 to October 2019 in patients of chronic pancreatitis presenting with pancreatic ascites. All patients underwent pancreatic protocol contrast enhanced computed tomography abdomen and magnetic resonance cholangiopancreatography, duct diameter and main pancreatic duct (MPD) disruption site. pseudocyst site was identified. After optimizing patients, early surgery was planned. Surgeries included either lateral pancreatic jejunostomy, if MPD were dilated. Pancreaticogastrostomy, cystogastrostomy or cystojejunostomy, if there was pseudocyst with extraneous impression over stomach or on mesocolon, and distal pancreatectomy (and/or) splenectomy. Results: Out of 20 cases of pancreatic ascites, 6 were of acute pancreatitis and conservatively managed and 14 were subjected to early primary surgery. 8 out of 14 patients underwent LPJ. 2/14 underwent pancreaticogastrostomy. 2/14 underwent cystogastrostomy and 1/14 underwent spleen preserving distal pancreatectomy. 1/14 underwent distal pancreatectomy and splenectomy. None of the patients had postoperative recurrence of pancreatic ascites. One patient developed Postoperative intra-abdominal collection which was drained. Mortality was 2/14 (14.2%), one died immediate postoperatively and another succumb to Pulmonary embolism on post-operative day-4. Pain scores were significantly reduced post-operatively.Conclusions: Primary early surgery directed towards primary pathology, as guided by MPD status, in selected patients with chronic pancreatitis with ascites leads to faster recovery of patient.
Clinicopathological profile of hoarseness of voice
Authors: Rathi Abhinav , Sharma Shalaka 
Published: February 2020

<p class="abstract"><strong>Background:</strong> Hoarseness of voice is one of the most common symptoms bringing a patient to an ear, nose and throat (ENT) Out Patient Department (OPD). Hoarseness of voice may arise from wide spectrum of diseases ranging from mild infections to fatal malignancies. Hence a study was done to know the incidence, etiology, predisposing factors and clinical profile of patients presenting with hoarseness of voice.</p><p class="abstract"><strong>Methods:</strong> The study was carried out in the Department of ENT, JNU IMSRC, Jaipur from Aug 2017 to July 2018. All the patients coming to ENT OPD with complaint of hoarseness of voice during that period underwent detailed history, clinical examination and routine investigations to know the exact cause of hoarseness. </p><p class="abstract"><strong>Results:</strong> A total of 126 cases with male:female ratio of 1.68:1 were analyzed. Patients age ranged from 13 to 82 years with majority of patients presenting in 4<sup>th</sup> decade. Most commonly hoarseness was seen in labourers (42.06%) with most common cause being vocal cord paralysis (23.01%) and majority of patients having smoking as the commonest predisposing factor (65%).</p><p class="abstract"><strong>Conclusions:</strong> The etiology of hoarseness varies from trivial infections to serious malignancies. In our tertiary centre which is at the outskirts of the city majority of the patients coming to OPD are from rural area and most of these patients are labourers by occupation and have a habit of smoking bidis.</p>
A cross sectional observational study of severity of allergic rhinitis and its impact on asthma
Authors: Kambatatti Shekharappa Munish , Urs Rohini D. 
Published: February 2020

<p class="abstract"><strong>Background:</strong> Allergic rhinitis (AR) and asthma are chronic diseases that often coexist and whose prevalence is increasing day by day. Uncontrolled allergic rhinitis may be associated with worsening of asthma and hence optimal treatment of AR may improve the coexisting asthma. The objective of the study was to study the severity of allergic rhinitis and its impact on asthma.</p><p class="abstract"><strong>Methods:</strong> A cross sectional study was conducted on 60 patients, at our Institute from November 2017 to June 2019 who were clinically diagnosed to have AR and asthma. Patients were evaluated by proper history taking, in detailed clinical examination and diagnostic nasal endoscopy and spirometry. </p><p class="abstract"><strong>Results:</strong> In our study out of 60 patients, majority fell in 20 to 40 age group. According to allergic rhinitis and its impact on asthma (ARIA) classification 10 (17%) had mild intermittent AR, 12 (20%) had mild persistent AR, 5 (8%) had moderate/severe intermittent AR and 33 (55%) had moderate or severe persistent AR. In case of moderate/severe persistent AR: 4 had intermittent, 9 had mild persistent, 10 had moderate persistent and 10 severe persistent asthma. Spearman’s rank correlation was done between severity of AR and severity of asthma, spearman’s rho: 0.365, p&lt;0.004 was significant.</p><p class="abstract"><strong>Conclusions:</strong> We noted that as the severity of allergic rhinitis increased, severity of asthma also increased, which was a linear correlation.</p>