bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resequencing of 672 native rice accessions to explore genetic diversity and trait associations along Vietnam
Authors: Higgins Janet , Santos Bruno , Khanh Tran Dang , Trung Khuat Huu , Duong Tran Duy , Doai Nguyen Thi Phuong , Khoa Nguyen Truong , Ha Dang Thi Thanh , Diep Nguyen Thuy , Dung Kieu Thi , Phi Cong Nguyen , Thuy Tran Thi , Tuan Nguyen Thanh , Tran Hoang Dung , Trung Nguyen Thanh , Giang Hoang Thi , Nhung Ta Kim , Tran Cuong Duy , Lang Son Vi , Nghia La Tuan , Giang Nguyen Van , Xuan Tran Dang , Hall Anthony , Dyer Sarah , Ham Le Huy , Caccamo Mario , Vega Jose J De 
Published: September 2020

Abstract
BACKGROUND:

Vietnam possesses a vast diversity of rice landraces due to its geographical situation, latitudinal range, and a variety of ecosystems. This genetic diversity constitutes a highly valuable resource at a time when the highest rice production areas in the low-lying Mekong and Red River Deltas are enduring increasing threats from climate changes, particularly in rainfall and temperature patterns.
RESULTS:

We analysed 672 Vietnamese rice genomes, 616 newly sequenced, that encompass the range of rice varieties grown in the diverse ecosystems found throughout Vietnam. We described four Japonica and five Indica subpopulations within Vietnam likely adapted to the region of origin. We compared the population structure and genetic diversity of these Vietnamese rice genomes to the 3,000 genomes of Asian cultivated rice. The named Indica-5 (I5) subpopulation was expanded in Vietnam and contained lowland Indica accessions, which had with very low shared ancestry with accessions from any other subpopulation and were previously overlooked as admixtures. We scored phenotypic measurements for nineteen traits and identified 453 unique genotype-phenotype significant associations comprising twenty-one QTLs (quantitative trait loci). The strongest associations were observed for grain size traits, while weaker associations were observed for a range of characteristics, including panicle length, heading date and leaf width.
CONCLUSIONS:

Our results highlight differences in genome composition and trait associations among traditional Vietnamese rice accessions, which are likely the product of adaption to multiple environmental conditions and regional preferences in a very diverse country. Our results highlighted traits and their associated genomic regions that are a potential source of novel loci and alleles to breed a new generation of sustainable and resilient rice.
Victimization in traditional and cyberbullying as risk factors for substance use, self-harm and suicide attempts in high school students
Authors: Azami Mohammad Saeed , Taremian Farhad 
Published: September 2020

Abstract

Background:
Traditional bullying (or peer bullying) is considered a common and unpleasant experience among students and has serious consequences such as mental health problems and unhealthy behavior. In recent years, another type of bullying named cyberbullying has emerged as a growing problem with negative effects on school achievement, physiology, and mental health of its victims.

Objective:
The purpose of this research is to examine and compare the roles of traditional and cyberbullying victimization in substance use, self-harm and suicide attempts.

Methods:
This was a cross-sectional study and conducted in 2019. A total of 425 high school students were selected for the study in Kermanshah, Iran. For conducting the survey, a multi-stage cluster randomized procedure was used and 18 classes in six different high schools in three urban areas were selected. A total of 400 students (mean age 16.61 years, 53.2% girls) responded to the survey, and it provided usable information for the research. Data were analyzed through binary logistic regression analyses.

Results:
The analysis results revealed that 54.2% of students (n = 217) have experienced traditional or cyber victimization. Any kind of victimization was associated with self-harm. Cyber victimization alone and the combination of cyber plus traditional victimization showed significant association with suicide and substance use. Risk of substance use, self-harm, and suicide was higher when students experienced both types of bullying than when they experienced just one kind of bullying alone.

Conclusions:
The results of this study suggest that traditional and cyber victims may require immediate intervention to reduce the negative effects of victimization. Also, prevention programs should consider the possible relationship between traditional and cyber victimization and substance use, self-harm, and suicide.
A simple field essay for detecting departures from expected performance in small-scale, remote or rural wastewater treatment plants
Authors: von Sperling Marcos , Lima Emmanuelle Machado Maia Nogueira , de Andrade Moraes Mirene Augusta 
Published: September 2020

Abstract
A scientific basis is given to the traditional method of inferring effluent quality based on visualization of samples in transparent flasks. A scale of 1–6, with different printed grey intensities, is placed behind transparent PET bottles containing the sample, and gives an indication of the range of turbidity in the sample (1 is the most transparent and can only be visualized if the effluent is well clarified; in the other spectrum, 6 is the darkest and indicates highly turbid effluents). Turbidity has been correlated with total suspended solids (TSS), particulate biochemical oxygen demand (BOD) and particulate chemical oxygen demand (COD) based on thousands of monitored data collected in the effluent from seven different treatment processes in Brazil: upflow anaerobic sludge blanket (UASB) reactor, trickling filters, activated sludge, horizontal wetland, vertical wetland, polishing ponds and coarse filter after pond. The method is simple and instantaneous, can be used in virtually all places and in every visit of the operator to the remote treatment plant, allows recording of the image in smartphones, does not use any equipment, chemicals or energy, and has been showed to represent well the effluent quality of existing treatment plants. This essay is complementary and does not substitute specific traditional sampling and analysis, but allows easy inference of deterioration of effluent quality.
PROPOSTA DE UMA CARTA GEOTÉCNICA PRELIMINAR DE FUNDAÇÕES PARA A REGIÃO CENTRO-NORTE DE FORTALEZA-CE
Authors: Pimentel Helano Wilson , Moura Alfran Sampaio , Carneiro Andressa de Araújo 
Published: September 2020

O artigo trata da estruturação do banco de dados de informações geotécnicas georeferenciado e elaboração de uma carta preliminar de fundações refente a região centro-norte da cidade de Fortaleza. Utilizando o software Google Earth, foi coletado 395 furos de sondagens à percussão em empresas locais e delineado 23 regiões. A partir de um tratamento estatístico, traçou-se mapas de isovalores de NSPT nas profundidades de 2, 5 e 10 m, do Nível d’água (NA) e para cada região foi determinada, ainda, uma sondagem representativa. Após estabelecido três portes de edificações elaborou-se uma carta preliminar de fundações. Conclui-se que o sistema utilizado no georeferenciamento dos dados coletados é adequado, possui fácil manuseio e utiliza arquivos de pequeno tamanho. Considerando edificações de pequeno porte, na maioria das vezes, pode-se utilizar fundações do tipo sapata assente a pequenas profundidades. Para edificações de médio e grande porte recomenda-se o uso de estacas e estima-se, preliminarmente, comprimentos que variam com o posicionamento da região.
Renin Angiotensin System (RAS) and Immune System Profile in Specific Subgroups with COVID-19
Authors: de Barcelos Ubaldo Martins Ludimila , Jabour Luiz Gustavo Pessoa Pires , Vieira Cristina Cerqueira , Nery Lucas Crepaldi Carvalho , Dias Raphael F. , Simões e Silva Ana Cristina 
Published: September 2020

Background:
The identification of vulnerable subgroups and risk factors associated with the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) are of
utmost importance in a pandemic scenario. Potential interactions between renin-angiotensin system (RAS), immune markers
and COVID-19 play a role in disease outcome in specific groups of patients.

Objective:
This review aimed to describe the particularities of the RAS and the immune system
profile of particular subgroups of patients.

Methods:
This non-systematic review summarizes evidence on SARS-CoV-2 infection in
specific subgroups of patients and possible relationships between immune system, RAS and
the pathophysiology of COVID-19.

Results:
The RAS and the immune system exert a role in the pathogenesis and prognosis of
COVID-19, mainly in cases of hypertension, diabetes, obesity and other chronic diseases. The
overactivation of the ACE/Ang II/AT1R axis and the enhancement of inflammation contribute
to deleterious effects of COVID-19. Likewise, pregnant women and elderly patients usually
display immune responses that are less effective in withstanding exposition to viruses,
while children are relatively protected against severe complications of COVID-19. Women,
conversely, exhibit stronger antiviral responses and are less sensitive to the effects of increased
Ang II.

Future Perspectives:
The recognition of vulnerable subgroups and risk factors for disease severity
is essential to better understand the pandemic. Precision medicine tools, including proteomics
and metabolomics approaches, identified metabolic patterns of the severe form of
disease and might be the alternative to diagnose, evaluate and predict the prognosis and the
efficiency of therapies.
Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study
Authors: Fuochi Virginia , Caruso Massimo , Emma Rosalia , Stivala Aldo , Polosa Riccardo , Distefano Alfio , Furneri Pio M. 
Published: September 2020

Background:The key ingredients of e-cigarettes liquid are commonly propane-1,2-diol (also called propylene glycol) and propane-1,2,3-triol (vegetal glycerol) and their antimicrobial effects are already established. The nicotine and flavors which are often present in e-liquids can interfere with the growth of some microorganisms. Objective: The effect of combining these elements in e-liquids is unknown. The aim of the study was to investigate the possible effects of these liquids on bacterial growth in the presence or absence of nicotine and flavors.Methods:Susceptibilities of pathogenic strains (Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Enterococcus faecalis and Sarcina lutea) were studied by means of a multidisciplinary approach. Cell viability and antioxidant assays were also evaluated.Results:All e-liquids investigated showed antibacterial activity against at least one pathogenic strain. A higher activity was correlated to the presence of flavors and nicotine.Discussion:In most cases the value of minimal bactericidal concentration is equal to the value of minimal inhibitory concentration showing that these substances have a bactericidal effect. This effect was observed in concentrations up to 6.25% v/v. Antioxidant activity was also correlated to presence of flavors. Over time, the viability assay in human epithelial lung A549 cells showed a dose-dependent inhibition of cell growth.Conclusion:Our results have shown that flavors considerably enhance the antibacterial activity of propane-1,2-diol and propane-1,2,3-triol. This study provides important evidence that should be taken into consideration in further investigative approaches, to clarify the different sensitivity of the various bacterial species to e-liquids, including the respiratory microbiota, to highlight the possible role of flavors and nicotine.
In Silico Study Examining New Phenylpropanoids Targets with Antidepressant Activity
Authors: da Silva Calixto Poliane , de Almeida Reinaldo Nóbrega , Stiebbe Salvadori Mirian G.S. , dos Santos Maia Mayara , Filho José Maria Barbosa , Scotti Marcus Tullius , Scotti Luciana 
Published: September 2020

Background:
Natural products, such as phenylpropanoids, which are found in essential
oils derived from aromatic plants, have been explored during non-clinical psychopharmacology
studies, to discover new molecules with relevant pharmacological activities in the central nervous
system, especially antidepressant and anxiolytic activities. Major depressive disorder is a highly debilitating
psychiatric disorder and is considered to be a disabling public health problem, worldwide,
as a primary factor associated with suicide. Current clinically administered antidepressants
have late-onset therapeutic actions, are associated with several side effects, and clinical studies
have reported that some patients do not respond well to treatment or reach complete remission.

Objective:
To review important new targets for antidepressant activity and to select phenylpropanoids
with antidepressant activity, using Molegro Virtual Docker and Ossis Data Warris, and to
verify substances with more promising antidepressant activity.

Results and Conclusion:
An in silico molecular modeling study, based on homology, was conducted
to determine the three-dimensional structure of the 5-hydroxytryptamine 2A receptor (5-
HT2AR), then molecular docking studies were performed and the predisposition for cytotoxicity
risk among identified molecules was examined. A model for 5-HT2AR homology, with satisfactory
results, was obtained indicating the good stereochemical quality of the model. The phenylpropanoid
4-allyl-2,6-dimethoxyphenol showed the lowest binding energy for 5-HT2AR, with results
relevant to the L-arginine/nitric oxide (NO)/cGMP pathway, and showed no toxicity within the parameters
of mutagenicity, carcinogenicity, reproductive system toxicity, and skin-tissue irritability,
when evaluated in silico; therefore, this molecule can be considered promising for the investigation
of antidepressant activity.
Formulation and Evaluation of Resveratrol Loaded Cubosomal Nanoformulation for Topical Delivery
Authors: Kurangi Bhaskar , Jalalpure Sunil , Jagwani Satveer 
Published: September 2020

Aim:
The aim of the study was to formulate, characterize, and evaluate the Resveratrol-
loaded Cubosomes (RC) for topical application.

Background:
Resveratrol (RV) is a nutraceutical compound with exciting pharmacological potential
in different diseases, including cancers. Many studies on resveratrol have been reported for anti-
melanoma activity. Due to its low bioavailability, the therapeutic activities of resveratrol are
strongly limited. Hence, an approach with nanotechnology has been made to increase its activity
through transdermal drug delivery.

Objective:
To formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC). To
evaluate Resveratrol-loaded Cubosomal Gel (RC-Gel) for its topical application.
Methods: RC was formulated by homogenization technique and optimized using a 2-factor 3-level
factorial design. Formulated RCs were characterized for particle size, zeta potential, and entrapment
efficiency. Optimized RC was evaluated for in vitro release and stability study. Optimized
RC was further formulated into cubosomal gel (RC-Gel) using carbopol and evaluated for drug
permeation and deposition. Furthermore, developed RC-Gel was evaluated for its topical application
using skin irritancy, toxicity, and in vivo local bioavailability studies.

Methods:
RC was formulated by homogenization technique and optimized using a 2-factor 3-level factorial design. Formulated RCs were characterized for particle size, zeta potential, and entrapment efficiency. Optimized RC was evaluated for in
vitro release and stability study. Optimized RC was further formulated into cubosomal gel (RC-Gel) using carbopol and
evaluated for drug permeation and deposition. Furthermore, developed RC-Gel was evaluated for its topical application using skin irritancy, toxicity, and in vivo local bioavailability studies.

Results:
The optimized RC indicated cubic-shaped structure with mean particle size, entrapment efficiency,
and zeta potential were 113±2.36 nm, 85.07 ± 0.91%, and -27.40 ± 1.40 mV, respectively.
In vitro drug release of optimized RC demonstrated biphasic drug release with the diffusion-controlled
release of resveratrol (RV) (87.20 ± 3.91%). The RC-Gel demonstrated better drug permeation
and deposition in mice skin layers. The composition of RC-Gel has been proved non-irritant to
mice skin. In vivo local bioavailability study depicted the good potential of RC-Gel for skin localization.

Conclusion:
The RC nanoformulation proposes a promising drug delivery system for melanoma
treatment simply through topical application.
Self-Treatment with Antibiotics: Knowledge level, Prevalence and Indications for Practicing Among University Students in Jordan
Authors: Najjar Yahya , Hassan Zeinab 
Published: September 2020

Background:
Self-treatment with antibiotics involves obtaining medicines without a prescription,
sharing medicines with members of one’s social circle, or using leftover medicines
stored at home.

Objective:
Assess the prevalence, knowledge level, reasons for practicing self-treatment of antibiotic
among undergraduate university students.

Methods:
The study was conducted cross-sectional on a sample of 201 students. A pre-validated
questionnaire called “self-treatment with antibiotics”, containing 27 close-ended questions, was administered
to each subject. Data were analyzed using SPSS version 16 and the results were expressed
as counts and percentages.

Results and Discussion:
Knowledge about self-treatment with antibiotics was good in general, and
health-related students had a better level of knowledge about self-treatment with antibiotics than
non-health-related students. The majority of the participants had not used self-treatment with antibiotics.
Gender, age, and the last time antibiotic taken affected self-treatment with antibiotics. The
most common indication for self-treatment with antibiotics was flu, cold, and tonsillitis. The most
common reason for practicing self-treatment with antibiotics was being considered as a convenient
and rapid solution. Internet was the main source for university students regarding knowledge about
antibiotic use and resistance.

Conclusion:
Self-treatment with antibiotics is affected by several social and demographic variables,
and the role of media, public policies, university curricula as well as physicians and pharmacists
should be enforced and activated to eliminate inappropriate uses of antibiotics and to correct
misconceptions that encourage self-treatment with antibiotics.
NURSING CARE OF PATIENT WITH SEPSIS DUE TO BLAST INJURY
Authors: Sari Efris Kartika , Nisofa Nisofa , Saputra Rendi Yoga , Masriami Masriami , Khoirudin Muhammad , Lahamukang Richardus MGP , Thomas Klara Yunita Inuq 
Published: September 2020

Blast injury is an injury due to the mechanism of barotrauma (involving excessive pressure) which results in organ trauma. Trauma and extensive injury can progress to sepsis condition to the patient. A man is hospitalized due to blast injury. The patient suffered a third-degree burn involving 18% total body surface area locateÂ in the abdomen and right thigh, and right femoral trauma. The patient has right hip disarticulation and abdominal wound debridement surgery. After surgery, the patient has decreased consciousness and respiratory failure so that he was treated in the intensive care unit. The nursing assessment identified that patient has sepsis conditions. Nursing problems of the patient are ineffective airway clearance, impaired spontaneous ventilation, the risk for shock, and impaired tissue integrity. The nurse performs nursing care to maintain airway patency, provide adequate ventilation, maintain hemodynamic stability, and optimize the wound healing process of the patient.
Circuitos productivos regionales: apuntes para una renovada herramienta analítica sobre procesos económicos en América Latina a principios de siglo XXI
Authors: Garcia Ariel , Rofman Alejandro 
Published: September 2020

En esta investigación retomamos la discusión teórica en torno a la herramienta analítica de circuito productivo regional. En función de ello, avanzaremos en el análisis de las modalidades de vinculación entre agentes económicos de desigual poder y capacidad de negociación en el mercado, en el escenario histórico de principios de siglo XXI y en el contexto productivo de las estructuras semi-periféricas de diversos países de América Latina. Nuestra herramienta analítica considera relevante la participación que detenta la intervención del sector público en la variación de las tasas de ganancia. En este juego de ganadores y perdedores, la capacidad de cada agente económico y social en alcanzar la tasa de ganancia que pretende o el ingreso al que aspira está en permanente modificación, acorde con los efectos que produce el despliegue de las políticas estatales, así como por la capacidad efectiva de cada quien para influir sobre su direccionamiento.
The Role of Accounting in Ponzi Schemes
Authors: Deason Stephen , Rajgopal Shivaram , Waymire Gregory B. , White Roger M. 
Published: September 2020

SYNOPSIS
Do accounting reports bolster investors' trust? We examine this question by modeling the incremental effect of Ponzi scheme operators providing accounting reports on the magnitude and lifespan of the underlying fraud. This investigation is possible in our setting because some, but not all, Ponzi scheme operators provide discretionary accounting reports (like falsified financial statements or fictional audit opinions) to current and potential investors. We observe that falsified audit reports lower the likelihood of regulatory detection by about 40 percent, and falsified accounting statements increase individual investor contributions by about 30 percent. Together, these results indicate that accounting reports bolster investors' trust, and that fraudsters can exploit trust in accounting institutions to maximize gains and minimize the likelihood of detection, even when accounting misrepresentations are not necessary.
JEL Classifications: D14; D19; G18.