bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive pathway-related genes signature for prognosis and recurrence of ovarian cancer
Authors: Zhao Xinnan , He Miao 
Published: December 2020

Background
Ovarian cancer (OC) is a highly malignant disease with a poor prognosis and high recurrence rate. At present, there is no accurate strategy to predict the prognosis and recurrence of OC. The aim of this study was to identify gene-based signatures to predict OC prognosis and recurrence.

Methods
mRNA expression profiles and corresponding clinical information regarding OC were collected from The Cancer Genome Atlas (TCGA) database. Gene set enrichment analysis (GSEA) and LASSO analysis were performed, and Kaplan–Meier curves, time-dependent ROC curves, and nomograms were constructed using R software and GraphPad Prism7.

Results
We first identified several key signalling pathways that affected ovarian tumorigenesis by GSEA. We then established a nine-gene-based signature for overall survival (OS) and a five-gene-based-signature for relapse-free survival (RFS) using LASSO Cox regression analysis of the TCGA dataset and validated the prognostic value of these signatures in independent GEO datasets. We also confirmed that these signatures were independent risk factors for OS and RFS by multivariate Cox analysis. Time-dependent ROC analysis showed that the AUC values for OS and RFS were 0.640, 0.663, 0.758, and 0.891, and 0.638, 0.722, 0.813, and 0.972 at 1, 3, 5, and 10 years, respectively. The results of the nomogram analysis demonstrated that combining two signatures with the TNM staging system and tumour status yielded better predictive ability.

Conclusion
In conclusion, the two-gene-based signatures established in this study may serve as novel and independent prognostic indicators for OS and RFS.
Compensación económica para el cónyuge o conviviente civil: Una mirada desde el análisis económico del Derecho
Authors: Palavecino Cáceres Adriana 
Published: December 2020

El análisis económico del derecho (AED) constituye una metodología que aplica a cuestiones de carácter jurídico, principios y conceptos de orden económico. Es una perspectiva de análisis de las instituciones jurídicas partiendo del supuesto que éstas tienen un carácter teleológico, están al servicio de los particulares, por lo tanto, su diseño, interpretación y aplicación, deben hacerse tratando de potenciar el bienestar de la sociedad en su conjunto.La compensación económica es una figura reciente en el Derecho de Familia chileno, la doctrina nacional le ha dado diversa calificación jurídica y todavía es objeto de análisis dogmático, por ello, estimamos que puede resultar interesante una aproximación desde la perspectiva del análisis económico del Derecho, intentando responder a las interrogantes típicas de este enfoque, a saber, ¿Si es eficiente la asignación de recursos o responsabilidades en su regulación por la ley de matrimonio civil? O en otras palabras, ¿Si la regulación de esta figura en favor del cónyuge más débil generará mayor satisfacción individual y social?
El debate sobre la noción de Path Dependence y su conciliación en un modelo dinámico de análisis institucional
Authors: Trigo Luis Gonzalo 
Published: December 2020

El presente trabajo se encuentra estructurado en dos partes, la primera, intenta identificar el debate actual sobre la noción de Path Dependence en la literatura académica, evidenciando sus posibles limitaciones y potencialidades definicionales. A partir de lo anterior, la segunda parte, busca establecer una conciliación de las distintas conceptualizaciones, de manera tal, apostar por un modelo dinámico de análisis institucional basado en una visión integral de Path Dependence. Entonces, un Modelo Dinámico de Path Dependence implica otorgarle un rol específico a cada conceptualización del debate en una estructura analítica general. En este sentido, la integración de las distintas conceptualizaciones del debate en un solo modelo dinámico permitiría considerar que el nodo central del análisis del desarrollo institucional pasa por la observación de las relaciones micro-causales de una o varias secuencias de tiempo las cuales pueden auto-reforzarse o terminar en ruptura, es decir, una dinámica de cierre y apertura institucional que determina la continuidad y el cambio.
Nutrient Analysis and Antimicrobial Activities of the Leaves and Fruit Pulp Extracts of Tetrapluera tetraptera on Clinical Bacteria Isolates
Authors: Ebana R. U. B. , Edet U. O. , Andy I. E. , Etok C. A. , Etim V. J. , Anosike K. I. 
Published: December 2020

Introduction: Plants are known to contain numerous phytochemicals with potential antimicrobial activity.
Aim: Nutritional, phytochemical and antimicrobial activities of the leaves and the fruit pulp extracts of Tetrapluera tetraptera was carried out.
Methodology: Collection and identification of isolates and plants parts, and preparation of extracts and nutrient (proximate, vitamins and minerals and anti-nutrients) evaluations were all done using standard protocols previously reported. Evaluations of phytochemicals were carried out using crude screening, quantification and gas chromatography coupled to mass spectrophotometer for a robust analysis. Antimicrobial activities were evaluated using the standard disc method and chloramphenicol as control.
Results: The results revealed varying amounts of proximate nutrients (ash, fibre, moisture, carbohydrate, protein and fat) in both samples. Vitamin analysis showed the presence of vitamin A, total and soluble vitamin C, niacin, riboflavin and thiamin in both samples. Furthermore, both samples had minerals such as Na, K, CA, P, Mg, Zn, Fe, and Cu, and K, Na, Ca, Mg, P, Fe, Zn and Cu in order of decreasing abundance in the fruit pulp and leaves, respectively. Both samples showed the presence of permissible levels of anti-nutrients compared to edible vegetables. Using all three methods, several phytochemicals such as terpenes, alkaloids, flavonoids, polyphenol, organic and fatty acids, amongst other in various amounts were obtained in the samples. Antimicrobial activities against identified clinical isolates used in this study which were Escherichia coli, Staphylococcus aureus and Proteus spp with both extracts ranged from 12.78±0.03 to 17.34±0.34 mm.
Conclusion: Given the rising cases of antimicrobial resistance and absence of newer antibiotics, the antimicrobial activity of our study plant is worth further evaluations.
Investigating the Growth and Yield of Upland Rice Using Application of Trichocompost and NPK Fertilizers at Dry Land
Authors: Novriani . , Gribaldi . , Nurlaili . , Dewi Nurmala , Sakalena Firnawati 
Published: December 2020

Upland rice production at South Sumatra is still low compared to national average production level due to low soil fertility. Therefore, effort to increase soil fertility level is needed such as through application of Trichocompost and NPK fertilizers at dry land area. This research objective was to determine the application effect of Trichocompost produced from rice straw and NPK fertilizers on the growth and yield of upland rice crop of henic strain at dry land area. The methods used in this research was a 2 by 3 Factorial in Completely Randomized Design with two treatment factors and three replications for each treatment. Trichocompost fertilizer treatments (T) were consisted of: T0 (without Trichocompost: 0 ton/ha; T1: 10 ton/ha Trichocompost; T2: 20 ton/ha Trichocompost and T3: 30 ton/ha Trichocompost, whereas NPK fertilizer treatments (P) were consisted of: P1: 200 kg NPK/ha; P2: 300 kg NPK/ha and P3: 400 kg NPK/ha. All data from this research was analyzed using Analysis of Variance to determine the given treatment effect by using SPSS 17.0 software. The results showed that application of Trichocompost produced from rice straw and NPK fertilizers had effect on the growth and yield of upland rice of henic strain at dry land area. Application of Trichocompost fertilizer produced from rice straw at dose of 30 ton/ha and NPK fertilizer at dose of 400 kg/ha tend to produce higher rice yield with magnitude of 4.6 kg/plot than that of other treatments.
Trends Analysis of Stream Flow at Different Gauging Stations in Upper Jhelum River
Authors: Pandey Yogesh , Mishra A. K. , Sarangi A. , Singh D. K. , Sahoo R. N. , Sarkar S. 
Published: December 2020

Analysis of stream flow trends plays a significant role in the flood forecasting and hydrologic drought assessment related investigations besides study of water resource management In this study, the long-term stream flow data recorded at different gauging stations in Upper Jhelum River (UJR) in Jammu and Kashmir (J &K) state basin were estimated using the Modified Mann-Kendall Test (MMKT) and Sen’s Slope Estimator (SSE).Long term time series data of ten gauging stations used for trend analysis were annual maximum and monthly maximum stream flows for the years (1980-2016) for the months of occurrence of flood in UJRB. It was observed that six gauging stations out of the ten showed a significant decreasing trend in discharge and depth of flow in the UJRB at 0.05 probability level of significance. However the results of the monthly and seasonal maximum stream flow analysis showed that during spring season (March to May) about 90% of the gauging stations depicted downward trends in the summer season (Jun to Aug) all the gauging stations showed downward stream flow trends and approximately 60% of the gauging stations showed downward trends in the month of September (first month of autumn). This analysis resulted into quantification of flood magnitudes and its periodicity of occurrences to develop flood mitigation strategies. Nonetheless, such investigation of water flow in the river would also assist in regional hydrologic studies besides occurrence of flood and hydrologic droughts.
The Prevalence of Bacteremia among Patients Admitted to a Military Hospital in Alkharj
Authors: Ahmed Nehad J. , Mahmoud Salwa , Menshawy Menshawy A. 
Published: December 2020

Aim: The aim of this study is to determine the prevalence of bacteremia among patients admitted to a military hospital in Alkharj and to know the causative organisms.
Methodology: Bacteria culture results were collected from the laboratory of the military hospital after the approval of the study by IRB ethical committee. The data were collected and analyzed using Excel spreadsheet 2016 and the descriptive data were represented as frequencies (n) and percentages (%).
Results: The total number of positive blood culture were 131 cultures, about 53.44% of the causative bacteria were gram positive bacteria. Generally, a high percentage of bacteremia was caused by Staphylococcus species, especially Coagulase-negative staphylococcus (25.19%) and Staphylococcus aureus (22.90%).
Conclusion: It can be concluded that the incidence of bloodstream infection in the present study is high and that the most common causative pathogens were Coagulase-negative staphylococcus and Staphylococcus aureus. It is important to know the incidence of bloodstream infection and to know the causative organisms both for clinical practice, especially to evaluate the effectiveness of interventions and also for research activities.
Toward a taxonomy of manufacturing flexibility dimensions
Authors: D'Souza Derrick E , Williams Fredrik P 
Published: July 2002

AbstractResearchers agree on the importance of manufacturing flexibility but are somewhat divided on the dimensions of this important construct. This paper seeks to find a middle‐ground by working toward a generally acceptable taxonomy of manufacturing flexibility dimensions. The authors build on extant literature and propose a theoretically grounded operationalization of the manufacturing flexibility construct. Operational measures of manufacturing flexibility dimensions are identified and tested on a sample of 240 manufacturing firms. Results indicate good support for the theorized taxonomy.
A new approach to young measure theory, relaxation and convergence in energy
Authors: Sychev M.A. 
Published: July 2002

The main idea of this paper is to reduce analysis of behavior of integral functionals along weakly convergent sequences to operations with Young measures generated by these sequences. We show that Young measures can be characterized as measurable functions with values in a special compact metric space and that these functions have a spectrum of properties sufficiently broad to realize this idea.

These new observations allow us to give simplified proofs of the results of gradient Young measure theory and to use them for deriving the results on relaxation and convergence in energy
under optimal assumptions
on integrands.

We think that this work helps to clarify role of Young measures.

Résumé
L’idée principale de cet article est de ramener l’analyse du comportement de fonctionnelles intégrales portant sur des suites faiblement convergentes à des opérations sur les mesures de Young associées à ces suites. Nous montrons que les mesures de Young peuvent être caractérisées comme des fonctions mesurables à valeurs dans un certain espace métrique compact et que ces fonctions ont un ensemble de propriétés suffisament large pour mettre en œuvre cette idée.
Ces nouvelles observations nous permettent de donner des démonstrations simplifiées de résultats en théorie du gradient des mesures de Young et de les utiliser pour obtenir des résultats sur la relaxation et la convergence en énergie sous des hypothèses optimales sur les intégrandes.
Nous pensons aussi que ce travail aide à clarifier le rôle des mesures de Young.
Weak compactness of wave maps and harmonic maps
Authors: Freire Alexandre , Müller Stefan , Struwe Michael 
Published: July 2002

We show that a weak limit of a sequence of wave maps in (1 + 2) dimensions with uniformly bounded energy is again a wave map. Essential ingredients in the proof are Hodge structures related to harmonic maps,

\mathcal{H}^{1}

estimates for Jacobians,

\mathcal{H}^{1}

-BMO duality, a “monotonicity” formula in the hyperbolic context and the concentration compactness method. Application of similar ideas in the elliptic context yields a drastically shortened proof of recent results by Bethuel on Palais–Smale sequences for the harmonic map functional on two dimensional domains and on limits of almost

H

-surfaces.

Résumé

La limite faible d’une suite d’applications d’ondes bornée en énergie est de nouveau une application d’ondes (au sens faible). La démonstration utilise de façon essentielle les structures de Hodge associćes aux applications harmoniques (ou aux applications d’ondes), des estimations dans l’espace

\mathcal{H}^{1}

de Hardy pour les Jacobiens (dualité

\mathcal{H}^{1}

-BMO), une « formule de monotonicité å dans le contexte hyperbolique, et la méthode de concentration-compacité. Dans le cas elliptique, nos idées fournissent une démonstration très simple et naturelle de résultats récents pour la convergence de suites Palais–Smale pour la fonctionnelle liée aux applications harmoniques en dimension deux et pour les surfaces à courbure moyenne prescrite, dues à Bethuel.
Reduced expression of voltage‐gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus
Authors: Stoll James , Galdzicki Zygmunt 
Published: July 2002

AbstractVoltage‐gated sodium channels are responsible for the initial depolarizing phase of the action potential. In hippocampal neurons cultured from trisomy 16 (Ts16) mice (a model for Down's syndrome), the maximum inward conductance mediated by these channels was reduced 47% relative to control diploid neurons. This reduced conductance was reflected in a 35% decrease in binding of radiolabeled saxitoxin, a sodium channel‐specific ligand, indicating expression of fewer channels in these neurons. The mRNAs encoding the α and β1 subunits were, however, present at the same levels in Ts16 neurons and control diploid neurons. Thus, the altered regulation of voltage‐gated sodium channels in Ts16 neurons is apparently a post‐transcriptional event and possible mechanisms are discussed.
Predictors of improvement in quality of life of long-term mentally ill individuals receiving case management
Authors: Björkman T. , Hansson L. 
Published: July 2002

SummaryOne hundred and thirteen long-term mentally ill clients receiving case management were investigated with regard to psychosocial and clinical predictors of changes in subjective quality of life during an 18-month follow-up. Better psychosocial functioning and fewer psychiatric symptoms at baseline predicted a greater improvement in quality of life. A larger decrease in symptom severity and a greater improvement in the social network during the follow-up were identified as the most important predictors of a greater improvement in subjective quality of life. The results of the study suggest that an emphasis should be put on effective symptom management, a reduction of needs for care and social support in order to fulfill the aims of improving subjective quality of life in patients receiving case management.
Computed tomography study of pineal calcification in schizophrenia
Authors: Bersani G , Garavini A , Taddei I , Tanfani G , Nordio M , Pancheri P 
Published: July 2002

SummaryComputed tomography studies concerning pineal calcification (PC) in schizophrenia have been conducted mainly by one author who correlated this calcification with several aspects of the illness. On the basis of these findings the aim of the present study was to analyze size and incidence of pineal gland calcification by CT in schizophrenics and healthy controls, and to verify the relationship between pineal calcification and age, and the possible correlation with psychopathologic variables. Pineal calcification was measured on CT scans of 87 schizophrenics and 46 controls divided into seven age subgroups of five years each. No significant differences in PC incidence and mean size between patients and controls were observed as far as the entire group was considered. PC size correlated with age both in schizophrenics and controls. We found a higher incidence of PC in schizophrenics in the age subgroup of 21–25 years, and a negative correlation with positive symptoms of schizophrenia in the overall group. These findings could suggest a premature calcific process in schizophrenics and a probable association with `non-paranoid' aspects of the illness. Nevertheless the potential role of this process possibly related to some aspects of the altered neurodevelopment in schizophrenia is still unclear.
Low‐Temperature‐Deposited TiO2 Nanopillars for Efficient and Flexible Perovskite Solar Cells
Authors: Wu Zhongwei , Li Peng , Zhao Jie , Xiao Ting , Hu Hong , Sun Peng , Wu Zehan , Hao Jianhua , Sun Chunlin , Zhang Haoli , Huang Zhifeng , Zheng Zijian 
Published: December 2020

AbstractOrganometal halide perovskite solar cells (PSCs) are promisingly applied to flexible solar cells because of the high power conversion efficiency (PCE) and intrinsic softness of perovskite materials. In the most efficient PSCs, mesoporous TiO2 generally functions as the electron transporting layer. However, the mesoporous TiO2 is typically generated through high‐temperature thermal annealing that is not suitable for producing flexible PSCs. In this work, TiO2 nanopillar arrays are directly deposited on flexible substrates using glancing angle deposition at low substrate temperature. The TiO2 nanopillars strongly adhere to the flexible substrates, improving light harvesting in the perovskite layers, facilitating electron extraction and transportation, and enhancing the mechanical flexibility of the PSCs. The flexible PSCs hybridized with the TiO2 nanopillars show a PCE as high as 13.3% and excellent photovoltaic stability after 500 cycles of bending at a small radius of curvature.
Diagnostic power and clinical impact of exome sequencing in a cohort of 500 patients with rare diseases
Authors: Quaio Caio Robledo D'Angioli Costa , Moreira Caroline Monaco , Novo‐Filho Gil Monteiro , Sacramento‐Bobotis Patricia Rossi , Groenner Penna Michele , Perazzio Sandro Felix , Dutra Aurelio Pimenta , da Silva Rafael Alves , Santos Monize Nakamoto Provisor , de Arruda Vanessa Yurie Nozaki , Freitas Vanessa Galdeno , Pereira Vinícius Ceola , Pintao Maria Carolina , Fornari Alexandre Ricardo dos Santos , Buzolin Ana Lígia , Oku Andre Yuji , Burger Matheus , Ramalho Rodrigo Fernandes , Marco Antonio David Santos , e Ferreira Elisa Napolitano , Pereira Otavio Jose Eulalio , Cantagalli Vanessa Dionisio , Trindade Ana Carolina Gomes , de Sousa Rafaela Rogerio Floriano , Reys Furuzawa Cintia , Verzini Fernanda , Matalhana Shirley Dezan , Romano Naiade , Paixão Daniele , Olivati Caroline , Spolador Gustavo Marquezani , Maciel Gustavo Arantes Rosa , Rocha Viviane Zorzanelli , Miguelez Javier , de Carvalho Mario Henrique Burlacchini , de Souza Alexandre Wagner Silva , Andrade Luis Eduardo Coelho , Chauffaille Maria de Lourdes , Perazzio Aline dos Santos Borgo , Catelani Ana Lucia Pereira Monteiro , Mitne‐Neto Miguel , Kim Chong Ae , Baratela Wagner Antonio da Rosa 
Published: December 2020

AbstractRare diseases comprise a diverse group of conditions, most of which involve genetic causes. We describe the variable spectrum of findings and clinical impacts of exome sequencing (ES) in a cohort of 500 patients with rare diseases. In total, 164 primary findings were reported in 158 patients, representing an overall diagnostic yield of 31.6%. Most of the findings (61.6%) corresponded to autosomal dominant conditions, followed by autosomal recessive (25.6%) and X‐linked (12.8%) conditions. These patients harbored 195 variants, among which 43.6% are novel in the literature. The rate of molecular diagnosis was considerably higher for prenatal samples (67%; 4/6), younger children (44%; 24/55), consanguinity (50%; 3/6), gastrointestinal/liver disease (44%; 16/36) and syndromic/malformative conditions (41%; 72/175). For 15.6% of the cohort patients, we observed a direct potential for the redirection of care with targeted therapy, tumor screening, medication adjustment and monitoring for disease‐specific complications. Secondary findings were reported in 37 patients (7.4%). Based on cost‐effectiveness studies in the literature, we speculate that the reports of secondary findings may influence an increase of 123.2 years in the life expectancy for our cohort, or 0.246 years/cohort patient. ES is a powerful method to identify the molecular bases of monogenic disorders and redirect clinical care.
On the potential of polyetheretherketone matrix composites reinforced with ternary nanolaminates for tribological and biomedical applications
Authors: Javaid Sabah , Dey Maharshi , Kaabouch Naima , Gupta Surojit 
Published: December 2020

AbstractWe report the synthesis and characterization of PEEK‐MAX (Ti3SiC2, Ti3AlC2, and Cr2AlC), and PEEK‐MoAlB composites by hot‐pressing. Detailed microstructure analysis by scanning electron microscopy showed that Ti3SiC2 particles are well dispersed in the PEEK matrix after the addition of 5 vol% Ti3SiC2 but at higher concentration (≥10 vol%), the Ti3SiC2 particles segregated at the phase boundaries and formed interpenetrating micro‐networks. PEEK‐Ti3AlC2 and PEEK‐MoAlB composites also showed similar structuring at the microstructural level. PEEK‐Cr2AlC composites showed a different behavior where Cr2AlC particles were well dispersed in the PEEK matrix. All the three PEEK‐MAX composites have lower hardness than PEEK‐MoAlB composites as MoAlB particulates are appreciably harder than MAX phases but were harder than PEEK. Due to heterogenous nucleation, the addition of MAX phases or MoAlB reduced the crystallization temperature (Tc) by a few oC. The formation of imperfect crystals also resulted in the lowering of melting point (Tm) of these composites. PEEK reinforced with 10 vol% Ti3SiC2, Ti3AlC2 and MoAlB showed plastic failure, and had higher strength than PEEK. Comparatively, PEEK reinforced with 10 vol% Cr2AlC did not show any enhancement. All the PEEK‐MAX and PEEK‐MoAlB composites showed triboactive behavior and enhanced wear resistance.