bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of the straight-ahead preference in human visual cortex
Authors: Bogdanova Olena V. , Bogdanov Volodymyr B. , Durand Jean-Baptiste , Trotter Yves , Cottereau Benoit R. 
Published: December 2019

AbstractThe objects located straight-ahead of the body are preferentially processed by the visual system. They are more rapidly detected and evoke stronger BOLD responses in early visual areas than elements that are retinotopically identical but located at eccentric spatial positions. To characterize the dynamics of the underlying neural mechanisms, we recorded in 29 subjects the EEG responses to peripheral targets differing solely by their locations with respect to the body. Straight-ahead stimuli led to stronger responses than eccentric stimuli for several components whose latencies ranged between 70 and 350 ms after stimulus onset. The earliest effects were found at 70 ms for a component that originates from occipital areas, the contralateral P1. To determine whether the straight-ahead direction affects primary visual cortex responses, we performed an additional experiment (n = 29) specifically designed to generate two robust components, the C1 and C2, whose cortical origins are constrained within areas V1, V2 and V3. Our analyses confirmed all the results of the first experiment and also revealed that the C2 amplitude between 130 and 160 ms after stimulus onset was significantly stronger for straight-ahead stimuli. A frequency analysis of the pre-stimulus baseline revealed that gaze-driven alterations in the visual hemi-field containing the straight-ahead direction were associated with a decrease in alpha power in the contralateral hemisphere, suggesting the implication of specific neural modulations before stimulus onset. Altogether, our EEG data demonstrate that preferential responses to the straight-ahead direction can be detected in the visual cortex as early as about 70 ms after stimulus onset.
Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets
Authors: Thibau Arno , Dichter Alexander A. , Vaca Diana J. , Linke Dirk , Goldman Adrian , Kempf Volkhard A. J. 
Published: December 2019

AbstractThe current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is theNeisseriaadhesin A (NadA), which is currently used as a subunit in a licensed vaccine againstNeisseria meningitidis. Other TAAs that seem promising vaccine candidates are theAcinetobactertrimeric autotransporter (Ata), theHaemophilus influenzaeadhesin (Hia), and TAAs of the genusBartonella. Here, we review the suitability of various TAAs as vaccine candidates.
Non-rainfall Moisture: A Key Driver of Microbial Respiration from Standing Litter in Arid, Semiarid, and Mesic Grasslands
Authors: Evans Sarah , Todd-Brown Katherine E. O. , Jacobson Kathryn , Jacobson Peter 
Published: December 2019

AbstractModels assume that rainfall is the major moisture source driving decomposition. Non-rainfall moisture (NRM: high humidity, dew, and fog) can also induce standing litter decomposition, but there have been few measurements of NRM-mediated decomposition across sites and no efforts to extrapolate the contribution of NRM to larger scales to assess whether this mechanism can improve model predictions. Here, we show that NRM is an important, year-round source of moisture in grassland sites with contrasting moisture regimes using field measurements and modeling. We first characterized NRM frequency and measured NRM-mediated decomposition at two sites in the Namib Desert, Namibia (hyper-arid desert), and at one site in Iowa, USA (tallgrass prairie). NRM was frequent at all sites (85–99% of hours that litter was likely to be wet were attributed to NRM) and tended to occur in cool, high-humidity periods for several hours or more at a time. NRM also resulted in CO2release from microbes in standing litter at all sites when litter became sufficiently wet (> 5% gravimetric moisture for fine litter and > 13% for coarse), and significantly contributed to mass loss, particularly in the western Namib site that received almost no rain. When we modeled annual mass loss induced by NRM and rain and extrapolated our characterization of NRM decomposition to a final semiarid site (Sevilleta, New Mexico), we found that models driven by rainfall alone underestimated mass loss, while including NRM resulted in estimates within the range of observed mass loss. Together these findings suggest that NRM is an important missing component in quantitative and conceptual models of litter decomposition, but there is nuance involved in modeling NRM at larger scales. Specifically, temperature and physical features of the substrate emerge as factors that affect the microbial response to litter wetting under NRM in our sites, and require further study. Hourly humidity can provide an adequate proxy of NRM frequency, but site-specific calibration with litter wetness is needed to accurately attribute decomposition to periods when NRM wets litter. Greater recognition of NRM-driven decomposition and its interaction with other processes like photodegradation is needed, especially since fog, dew, and humidity are likely to shift under future climates.
A 19 year population-based cohort study analysing reoperation for recurrence following laparoscopic and open inguinal hernia repairs
Authors: Ramsay G. , Scott N. W. , Jansen J. O. 
Published: December 2019

Abstract
Introduction
Laparoscopic (LHR) and open (OHR) inguinal hernia repairs are both used to treat primary herniae. This study analyses the rates of operation for recurrence after laparoscopic and open inguinal hernia repair, at a population level, while considering competing risks, such as death and other operative interventions.

Methods
This is a population cohort study in Scotland. All adult patients who had a primary inguinal hernia repair in Scotland between 01/04/1996 and 01/01/2015 were included. The main outcome was recurrent operations. Cumulative incidence functions (CIF) were calculated for competing risks of death. A cox proportional hazards regression model was used to control for confounders of age, gender, bilateral herniae, deprivation and year of procedure.

Results
Of 88,590 patients, there were 10,145 LHR and 78,445 OHR. Recurrent operations were required in 1397 (1.8%) OHR and 362 (3.6%). LHR had greater hazard of recurrence than OHR (HR 1.83, 95% CI 1.61–2.08, p < 0.001). Faster time to recurrence was also associated with being older (HR for one year increase: 1.010, 95% CI 1.007–1.013, p < 0.001), being more affluent (HR 1.18, 95% CI 1.01–1.38, p = 0.04) and having a bilateral index operation (HR 2.53, 95% CI 2.22–2.88, p < 0.001).

Conclusions
LHR is becoming more popular in Scotland over the past 2 decades. However, when other key confounding factors are controlled, it is associated with a higher recurrence rate.
A novel algorithm to predict bone changes in the mouse tibia properties under physiological conditions
Authors: Cheong Vee San , Campos Marin Ana , Lacroix Damien , Dall’Ara Enrico 
Published: December 2019

AbstractUnderstanding how bone adapts to mechanical stimuli is fundamental for optimising treatments against musculoskeletal diseases in preclinical studies, but the contribution of physiological loading to bone adaptation in mouse tibia has not been quantified so far. In this study, a novel mechanistic model to predict bone adaptation based on physiological loading was developed and its outputs were compared with longitudinal scans of the mouse tibia. Bone remodelling was driven by the mechanical stimuli estimated from micro-FEA models constructed from micro-CT scans of C57BL/6 female mice (N = 5) from weeks 14 and 20 of age, to predict bone changes in week 16 or 22. Parametric analysis was conducted to evaluate the sensitivity of the models to subject-specific or averaged parameters, parameters from week 14 or week 20, and to strain energy density (SED) or maximum principal strain (εmaxprinc). The results at week 20 showed no significant difference in bone densitometric properties between experimental and predicted images across the tibia for both stimuli, and 59% and 47% of the predicted voxels matched with the experimental sites in apposition and resorption, respectively. The model was able to reproduce regions of bone apposition in both periosteal and endosteal surfaces (70% and 40% for SED and εmaxprinc, respectively), but it under-predicted the experimental sites of resorption by over 85%. This study shows for the first time the potential of a subject-specific mechanoregulation algorithm to predict bone changes in a mouse model under physiological loading. Nevertheless, the weak predictions of resorption suggest that a combined stimulus or biological stimuli should be accounted for in the model.
Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study
Authors: McCain R. Stephen , McManus Damian T. , McQuaid Stephen , James Jacqueline A. , Salto-Tellez Manuel , Reid Nathan B. , Craig Stephanie , Chisambo Chintapuza , Bingham Victoria , McCarron Eamon , Parkes Eileen , Turkington Richard C. , Coleman Helen G. 
Published: December 2019

Abstract
Purpose
To investigate the association between cigarette smoking, alcohol consumption, and esophageal adenocarcinoma survival, including stratified analysis by selected prognostic biomarkers.

Methods
A population-representative sample of 130 esophageal adenocarcinoma patients (n = 130) treated at the Northern Ireland Cancer Centre between 2004 and 2012. Cox proportional hazards models were applied to evaluate associations between smoking status, alcohol intake, and survival. Secondary analyses investigated these associations across categories of p53, HER2, CD8, and GLUT-1 biomarker expression.

Results
In esophageal adenocarcinoma patients, there was a significantly increased risk of cancer-specific mortality in ever, compared to never, alcohol drinkers in unadjusted (HR 1.96 95% CI 1.13–3.38) but not adjusted (HR 1.70 95% CI 0.95–3.04) analysis. This increased risk of death observed for alcohol consumers was more evident in patients with normal p53 expression, GLUT-1 positive or CD-8 positive tumors. There were no significant associations between survival and smoking status in esophageal adenocarcinoma patients.

Conclusions
In esophageal adenocarcinoma patients, cigarette smoking or alcohol consumption was not associated with a significant difference in survival in comparison with never smokers and never drinkers in fully adjusted analysis. However, in some biomarker-selected subgroups, ever-alcohol consumption was associated with a worsened survival in comparison with never drinkers. Larger studies are needed to investigate these findings, as these lifestyle habits may not only be linked to cancer risk but also cancer survival.
Enabling local adaptation to climate change: towards collective action in Flagler Beach, Florida, USA
Authors: Boda Chad Stephen , Jerneck Anne 
Published: December 2019

AbstractLocal communities around the world are directly exposed to impacts of climate change. It is also clear that many local governments are politically and economically constrained in their capacity to implement needed adaptations. These constraints can restrict adaptation options to incremental, or even maladaptive, practices. At the same time, necessary transformational actions may remain out of reach for local actors. Building on five years of collaborative research with the city of Flagler Beach (FL, USA), we draw on political process theories to describe how incremental adaptation activities that are possible within current constraints can serve to build local capacity for instigating reforms at higher scales of social organization. We use the concept of a collective action strategy to conceptualize how context-specific barriers to adaptation can be overcome. From our analysis, an idealized multi-step process for designing collective action strategies is presented. The study advances scholarship on limits to adaptation beyond the diagnosis of barriers to action by taking steps towards developing context-specific strategies for overcoming these barriers.
Production and characterization of Aspergillus niger GH29 family α-fucosidase and production of a novel non-reducing 1-fucosyllactose
Authors: Usvalampi Anne , Ruvalcaba Medrano Marcela , Maaheimo Hannu , Salminen Heidi , Tossavainen Olli , Frey Alexander D. 
Published: December 2019

AbstractFucosylated oligosaccharides are interesting molecules due to their bioactive properties. In particular, their application as active ingredient in milk powders is attractive for dairy industries. The objective of this study was to characterize the glycosyl hydrolase family 29 α-fucosidase produced byAspergillus nigerand test its ability to transfucosylate lactose with a view towards potential industrial applications such as the valorization of the lactose side stream produced by dairy industry. In order to reduce costs and toxicity the use of free fucose instead of environmentally questionable fucose derivatives was studied. In contrast to earlier studies, a recombinantly producedA. nigerα-fucosidase was utilized. Using pNP-fucose as substrate, the optimal pH for hydrolytic activity was determined to be 3.8. The optimal temperature for a 30-min reaction was 60 °C, and considering temperature stability, the optimal temperature for a 24-h reaction was defined as 45 °C For the same hydrolysis reaction, the kinetic values were calculated to be 0.385 mM for the KMand 2.8 mmol/(mg*h) for the Vmax. Transfucosylation of lactose occurred at high substrate concentrations when reaction time was elongated to several days. The structure of the product trisaccharide was defined as 1-fucosyllactose, where fucose is α-linked to the anomeric carbon of the β-glucose moiety of lactose. Furthermore, the enzyme was able to hydrolyze its own transfucosylation product and 2′-fucosyllactose but only poorly 3-fucosyllactose. As a conclusion, α-fucosidase fromA. nigercan transfucosylate lactose using free fucose as substrate producing a novel non-reducing 1-fucosyllactose.
Equity and Coverage in the Continuum of Reproductive, Maternal, Newborn and Child Health Services in Nepal-Projecting the Estimates on Death Averted Using the LiST Tool
Authors: Thapa Jeevan , Budhathoki Shyam Sundar , Gurung Rejina , Paudel Prajwal , Jha Bijay , Ghimire Anup , Wrammert Johan , KC Ashish 
Published: December 2019

Abstract
Introduction
The third Sustainable Development Goal, focused on health, includes two targets related to the reduction in maternal, newborn and under-five childhood mortality. We found it imperative to examine the equity and coverage of reproductive, maternal, newborn and child health (RMNCH) interventions from 2001 to 2016 in Nepal; and the death aversion that will take place during the SDG period.

Methods
We used the datasets from the Nepal Demographic Health Surveys (NDHS) 2001, 2006, 2011 and 2016. We calculated the coverage and equity for RMNCH interventions and the composite coverage index (CCI). Based on the Annualized Rate of Change (ARC) in the coverage for selected RMNCH indicators, we projected the trend for the RMNCH interventions by 2030. We used the Lives Saved Tools (LiST) tool to estimate the maternal, newborn, under-five childhood deaths and stillbirths averted. We categorised the interventions into four different patterns based on coverage and inequity gap.

Results
Between 2001 and 2016, a significant improvement is seen in the overall RMNCH intervention coverage-CCI increasing from 46 to 75%. The ARC was highest for skilled attendance at birth (11.7%) followed by care seeking for pneumonia (8.2%) between the same period. In 2016, the highest inequity existed for utilization of the skilled birth attendance services (51%), followed by antenatal care (18%). The inequity gap for basic immunization services reduced significantly from 27.4% in 2001 to 5% in 2016. If the current ARC continues, then an additional 3783 maternal deaths, 36,443 neonatal deaths, 66,883 under-five childhood deaths and 24,024 stillbirths is expected to be averted by the year 2030.

Conclusion
Nepal has experienced an improvement in the coverage and equity in RMNCH interventions. Reducing inequities will improve coverage for skilled birth attendants and antenatal care. The current annual rate of change in RMNCH coverage will further reduce the maternal, neonatal, under-five childhood deaths and stillbirths.
Occurrence and transformation of phenoxy acids in aquatic environment and photochemical methods of their removal: a review
Authors: Muszyński Paweł , Brodowska Marzena S. , Paszko Tadeusz 
Published: December 2019

AbstractThe article presents the behavior of phenoxy acids in water, the levels in aquatic ecosystems, and their transformations in the water environment. Phenoxy acids are highly soluble in water and weakly absorbed in soil. These highly mobile compounds are readily transported to surface and groundwater. Monitoring studies conducted in Europe and in other parts of the world indicate that the predominant phenoxy acids in the aquatic environment are mecoprop, 4-chloro-2-methylphenoxyacetic acid (MCPA), dichlorprop, 2,4-dichlorophenoxyacetic acid (2,4-D), and their metabolites which are chlorophenol derivatives. In water, the concentrations of phenoxy acids are effectively lowered by hydrolysis, biodegradation, and photodegradation, and a key role is played by microbial decomposition. This process is determined by the qualitative and quantitative composition of microorganisms, oxygen levels in water, and the properties and concentrations of phenoxy acids. In shallow and highly insolated waters, phenoxy acids can be decomposed mainly by photodegradation whose efficiency is determined by the form of the degraded compound. Numerous studies are underway on the use of advanced oxidation processes (AOPs) to remove phenoxy acids. The efficiency of phenoxy acid degradation using AOPs varies depending on the choice of oxidizing system and the conditions optimizing the oxidation process. Most often, methods combining UV radiation with other reagents are used to oxidize phenoxy acids. It has been found that this solution is more effective compared with the oxidation process carried out using only UV.
The Influence of Body Contouring Surgery on Weight Control and Comorbidities in Patients After Bariatric Surgery
Authors: de Vries C. E. E. , Kalff M. C. , van Praag E. M. , Florisson J. M. G. , Ritt M. J. P. F. , van Veen R. N. , de Castro S. M. M. 
Published: December 2019

Abstract
Introduction
A considerable number of patients experience some long-term weight regain after bariatric surgery. Body contouring surgery (BCS) is thought to strengthen post-bariatric surgery patients in their weight control and maintenance of achieved improvements in comorbidities.

Objectives
To examine the impact of BCS on long-term weight control and comorbidities after bariatric surgery.

Methods
We performed a retrospective study in a prospective database. All patients who underwent primary Roux-en-Y gastric bypass (RYGB) and presented for preoperative consultation of BCS in the same hospital were included in the study. Linear and logistic mixed-effect model analyses were used to evaluate the longitudinal relationships between patients who were accepted or rejected for BCS and their weight loss outcomes or changes in comorbidities.

Results
Of the 1150 patients who underwent primary RYGB between January 2010 and December 2014, 258 patients (22.4%) presented for preoperative consultation of BCS. Of these patients, 126 patients eventually underwent BCS (48.8%). Patients who were accepted for BCS demonstrated significant better ∆body mass index (BMI) on average over time (− 1.31 kg/m2/year, 95% confidence interval (CI) −2.52 − −0.10, p = 0.034) and percent total weight loss (%TWL) was significantly different at 36 months (5.79, 95%CI 1.22 – 10.37, p = 0.013) and 48 months (6.78, 95%CI 0.93 – 12.63, p = 0.023) after body contouring consultation. Patients who were accepted or rejected did not differ significantly in the maintenance of achieved improvements in comorbidities.

Conclusion
BCS could not be associated with the maintenance of achieved improvements in comorbidities after bariatric surgery, whereas it could be associated with improved weight loss maintenance at 36 and 48 months after body contouring consultation. This association should be further explored in a large longitudinal study.
Modification of NO-cGMP Pathway Differentially Affects Diazepam- and Flunitrazepam-Induced Spatial and Recognition Memory Impairments in Rodents
Authors: Orzelska-Górka Jolanta , Bernat Piotr , Tutka Piotr , Listos Joanna , Kędzierska Ewa , Fidecka Sylwia , Talarek Sylwia 
Published: December 2019

AbstractThis study investigated the influence of sildenafil and methylene blue (MB), two modulators of the nitric oxide (NO)-cyclic guanosine-3′,5′-monophosphate (cGMP) pathway on amnesic effects of two benzodiazepines (BZs) (diazepam (DZ) and flunitrazepam (FNZ)), in rodents—mice and rats. In the modified elevated plus maze (mEPM) and novel object recognition (NOR) tests, MB given ip at a dose of 5 mg/kg 5 min prior to DZ administration (0.25 or 1 mg/kg, sc) enhanced/induced memory impairment caused by DZ. When MB (2.5, 5, and 10 mg/kg) was applied 5 min prior to FNZ administration (0.05 and 0.1 mg/kg), an effect was opposite and memory impairment induced by FNZ was reduced. When sildenafil (2.5 and 5 mg/kg, ip) was applied 5 min prior to DZ, we observed a reduction of DZ-induced memory deficiency in the mEPM test. A similar effect of sildenafil was shown in the NOR test when the drug was applied at doses of 1.25, 2.5, and 5 mg/kg prior to DZ. In the mEPM test, sildenafil at abovementioned doses had no effects on FNZ-induced memory impairment. In turns, sildenafil administered at doses of 2.5 and 5 mg/kg increased the effect of FNZ on memory impairment in the NOR test. In conclusion, the NO-cGMP pathway is involved differentially into BZs-induced spatial and recognition memory impairments assessed using the NOR and mEPM tests. Modulators of the NO-cGMP pathway affect animal behavior in these tests in a different way depending on what benzodiazepine is applied.
Study on Pre-Deceleration Running in Encounters with Emergency Vehicles Using Vehicle to Vehicle Communications
Authors: Nanba Hideaki , Sawada Manabu , Oguri Koji 
Published: December 2019

AbstractThere is a problem of coordination in encounters with an emergency vehicle when an automated driving vehicle travels on public roads. Effectiveness of the pre-deceleration running based on the earlier recognition of emergency vehicle using vehicle to vehicle communication is studied from the viewpoint of safety and ride comfort. Experimental data of the driver’s maneuver and vehicle’s status are collected and analyzed using the driving simulator. Recognition by vehicle to vehicle communication (V2V for short) leads to pre-deceleration and improves deceleration and jerk as compared to siren sound and red light of emergency vehicles.