bluuebunny/crossref_metadata_2025_split huggingface dataset:
DLI-IT: A Deep Learning Approach to Drug Label Identification Through Image and Text Embedding
Authors: Liu Xiangwen , Meehan Joe , Tong Weida , Wu Leihong , Xu Xiaowei , Xu Joshua 
Published: January 2020

Abstract
[Background] Drug label, or packaging insert play a significant role in all the operations from production through drug distribution channels to the end consumer. Image of the label also called Display Panel or label could be used to identify illegal, illicit, unapproved and potentially dangerous drugs. Due to the time-consuming process and high labor cost of investigation, an artificial intelligence-based deep learning model is necessary for fast and accurate identification of the drugs. [Methods] In addition to image-based identification technology, we take advantages of rich text information on the pharmaceutical package insert of drug label images. In this study, we developed the Drug Label Identification through Image and Text embedding model (DLI-IT) to model text-based patterns of historical data for detection of suspicious drugs. In DLI-IT, we first trained a Connectionist Text Proposal Network (CTPN) to crop the raw image into sub-images based on the text. The texts from the cropped sub-images are recognized independently through the Tesseract OCR Engine and combined as one document for each raw image. Finally, we applied universal sentence embedding to transform these documents into vectors and find the most similar reference images to the test image through the cosine similarity. Results] We trained the DLI-IT model on 1749 opioid and 2365 non-opioid drug label images. The model was then tested on 300 external opioid drug label images, the result demonstrated our model achieves up-to 88% of the precision in drug label identification, which outperforms previous image-based or text-based identification method by up-to 35% improvement. [Conclusion] To conclude, by combining Image and Text embedding analysis under deep learning framework, our DLI-IT approach achieved a competitive performance in advancing drug label identification.
Effects of social support, hope and resilience on depressive symptoms among patients with newly diagnosed prostate cancer
Authors: Zhao Xinxin , Sun Ming , Yang Ye 
Published: January 2020

Abstract
Background The prevalence of depression symptoms and related modifiable factors in prostate cancer (PCa) are not well evaluated. We aimed to assess the effects of perceived social support, hope and resilience on depressive symptoms in newly diagnosed PCa patients, and to evaluate the role of hope and resilience as mediators of that relationship. Method A cross-sectional study was analyzed in consecutive inpatients with PCa during the months of January 2018 and August 2019. A questionnaire was administered to 667 patients. All registered patients were all volunteers and anonymous. Depressive symptoms, perceived social support, hope and resilience were measured anonymously. Out of 667 patients, a total of 564 effective respondents became our subjects. Hierarchical linear regression was used to identify the factors associated with depressive symptoms. Asymptotic and resampling strategies were used to conduct the mediating effects of hope and resilience Results The prevalence of depressive symptoms was 65.9% in PCa patients . Hierarchical regression analyses indicated that perceived social support, hope, and resilience together accounted for 27.5% variance of depressive symptoms. Support from family, hope, and resilience significantly associated with depressive symptoms, respectively. Hope (a*b = -0.0783, BCa95% CI:–0.134 to–0.0319, p < 0.05), and resilience (a*b = -0.1315, BCa95% CI:–0.1894 to–0.0783, p < 0.05) significantly mediated the association between perceived social support and depressive symptoms. Conclusions The high prevalence of depressive symptoms among newly diagnosed PCa patients should receive more attention. Perceived social support, hope and resilience could be positive resources for combating depressive symptoms, and hope and resilience mediated the association between perceived social support and depressive symptoms. Enhancing social support, particularly the support form family, and improving patients’ outlook and resilience may be potential targets for future psychosocial interventions aimed at reducing depressive symptoms.
Genome-wide identification and characterization of non-specific lipid transfer protein (nsLTP) genes in Arachis duranensis
Authors: Song Xiaojun , Li Enguang , Song Hui , Du Guoning , Li Shuai , Zhu Hong , Chen Guanxu , Zhao Chunmei , Qiao Lixian , Wang Jingshan , Yu Shanlin , Sui Jiongming 
Published: January 2020

Abstract
Background: Non-specific lipid transfer proteins (nsLTPs) are known to transfer various lipid molecules between lipid bilayers in plants. In Arachis duranensis, however, little is known about the nsLTPs and their responses to biotic and abiotic stresses. Results: In this study, we identified 64 nsLTP family members (AdLTPs) in A. duranensis. These AdLTPs were classified into six subfamilies (Types 1, 2, C, D, E, and G) and were randomly distributed along nine chromosomes. The Ks value and Ka/Ks value significantly differed between Type 1 and Type D subfamilies. Among paralogs, eight AdLTPs were under positive selection, indicating that these AdLTPs might have different functions in the evolutionary history of A. duranensis. qRT-PCR results showed that the expression of AdLTPs changed in response to abiotic stresses, including salinity, PEG, low temperature, and ABA. Using RNA-seq data, we also found three AdLTPs (AdLTP1.14, AdLTPd8, and AdLTPe2) that were possibly associated with resistance to nematode infection. Among them, AdLTP1.14, which belongs to the Type 1 subfamily, was up-regulated at three time points after nematode infection. Co-expression analysis indicated that DOF and WRI1 transcription factors may regulate the AdLTP response to nematode infection. Conclusions: We identified AdLTPs in A. duranensis. Based on both RNA-seq and qRT-PCR datasets, we found that AdLTPs are involved in responses to biotic and abiotic stresses. Our results could provide valuable genomic information for the breeding of peanut cultivars that are resistant to biotic and abiotic stresses.
Bioinformatics analysis of the expression and role of microRNA-221-3p in the head and neck squamous cell carcinoma
Authors: Zhou Ziyan , Wenling Wu , Jixi Li , Chang Liu , Zixi Xiao , Qinqiao Lai , Rongxing Qin , Mingjun Shen , Min Kang 
Published: January 2020

Abstract
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer subtype globally, associated with a high rate of morbidity and mortality. However, the target genes of miR-221-3p and the underlying mechanism involved in HNSCC were not known. Therefore, in the current study, we studied the role of miR-221-3p in the HNSCC. Methods Tissues collected from 48 control and 21 HNSCC patients were processed to check the differential expression of miR-221-3p by Real-time RT-Polymerase Chain Reaction (RT-qPCR). Overexpression of microRNA-221-3p (miR-221-3p) is significantly correlated to the onset and progression of HNSCC. We also conducted the meta-analysis of the cancer literature from the cancer genome atlas (TCGA) and the Gene Expression Omnibus (GEO) database to estimate the expression of miR-221-3p in HNSCC. The miR-221-3p target genes in the HNSCC were predicted with the miRWalk and TCGA databases, and functionally annotated via the Gene Ontology Finally, Spearman’s analysis was used to determine the role of the related target genes in important pathways involved in the development of HNSCC. Results We observed a significantly higher expression of miR-221-3p in HNSCC compared to the normal with a summary receiver operating characteristic (sROC) of 0.86(95% Cl: 0.83,0.89). The KEGG and GO comprehensive analysis predicted that miR-221-3p might be involved in the development of HNSCC through the following metabolic pathways, viz Drug metabolism - cytochrome P450 UGT1A7 and MAOB may be important genes for the role of mir-221-3p. Conclusions Our results indicate that miR-221-3p may be used as a non-invasive and hypersensitive biomarker in the diagnosis. Thus, it can be concluded that miR-221-3p is an extremely important gene locus involved in the process of the deterioration and eventual tumorigenesis of HNSCC.
Diagnostic and prognostic values of KRAS mutations on EUS-FNA specimens and circulating tumor DNA in patients with pancreatic cancer
Authors: Wang Ronghua , Wang Jinlin , Zhao Yuchong , Wang Yun , Zhao Zhenxiong , Chen Qian , Duan Yaqi , Cheng Bin 
Published: January 2020

Abstract
Background: Early diagnosis is critical in reducing pancreatic cancer mortality. We explore the diagnostic values of detecting KRAS gene mutations and plasma circulating tumor DNA (ctDNA) in patients with primary pancreatic cancer. Methods: The cohort study is comprised of 149 consecutive patients with pancreatic solid mass underwent Endoscopic ultrasound fine needle aspiration (EUS-FNA) between September, 2014 and May, 2016. KRAS point mutations (G12V, G12D, and G12R) were analyzed by droplet digital PCR (ddPCR) in EUS-guided fine needle aspiration (FNA) histopathology tissue samples and blood samples were tested for plasma ctDNA. The final diagnosis was based on surgical resection pathology or follow up for at least 2 years. Results: The sensitivity and accuracy of EUS-FNA diagnose was increased from 71.4% to 91.6% (P<0.001) and 75.8% to 88.6% (P <0.001), respectively, when KRAS mutation ddPCR analysis was added to standard EUS-FNA assessment. The sensitivity and accuracy of circulating biomarkers combination (ctDNA and CA19-9) were 78.9% and 76.2%, respectively. The median survival time was significantly shorter in patients with G12D mutations (180 days) compared to patients with other mutations (240 days) (long-rank test, P<0.001). Conclusions: KRAS mutation analysis in tissues significantly improves the sensitivity and accuracy of cyto/histopathological evaluation in EUS-FNA samples. The accuracy of KRAS mutation analysis in EUS-FNA samples was obviously higher than non-invasive blood-based ctDNA KRAS mutation in detecting pancreatic cancer. G12D KRAS mutation in pancreatic cancer were independently associated with poor overall survival.
Albumin infusion reduces the risk of rebleeding and in-hospital mortality in cirrhotic patients admitted for acute gastrointestinal bleeding: retrospective analysis of a single institute
Authors: Wang Zhu , Xie Ya-Wen , Lu Qing , Yan Hai-Lin , Liu Xin-Bin , Long Yi , Zhang Xian , Yang Jinlin 
Published: January 2020

Abstract
BackgroundTo investigate the effect of albumin infusion in cirrhotic patients admitted for acute gastrointestinal bleeding.MethodsMedical records of cirrhotic patients who admitted due to acute gastrointestinal bleeding through January 2009 to December 2018 were systemically reviewed. Clinical data and the total amount of albumin and red blood cell used during hospitalization were recorded. For patients with rebleeding, the amount of albumin and red blood cell used before rebleeding was also documented. The primary outcome was the occurrence of rebleeding and the second outcome was in-hospital mortality. Univariate and multivariate logistic analysis were performed to identify risk factors associated with rebleeding and in-hospital mortality.ResultsA total of 2239 cirrhotic patients were included in the analysis. There were 245 episodes of in-patient rebleeding occurred, while 135 patients died. Overall, more red blood cells and albumin were prescribed to patients who suffered rebleeding. In terms of the amount before rebleeding, the red blood cell was higher in patients with rebleeding, but the albumin infusion were similar. In the multivariate model, the albumin infusion was an independent risk factor associated with rebleeding (adjusted OR for ≤40g, 0.385 [0.252-0.588], p<0.001; OR for >40g, 0.295 [0.169-0.514], p<0.001). The use of albumin more than 40g during hospitalization reduces the risk of in-patient mortality (adjusted OR for ≤40g, 0.730 [0.375-1.423], p=0.356; OR for >40g, 0.389 [0.180-0.838], p=0.016).ConclusionsAlbumin infusion could reduce risk of in-hospital rebleeding. Moreover, more than 40g albumin infusion decrease numbers of mortality in cirrhosis admitted for acute gastrointestinal bleeding.
Colonisation by native shrubby species enhances the carbon storage capacity of exotic mangrove monocultures
Authors: He Ziying , Sun Huaye , Peng Yisheng , Hu Zhan , Cao Yingjie , Lee Shing Yip 
Published: January 2020

Abstract
BackgroundThe exotic Sonneratia apetala and native Kandelia obovata have been widely planted in mangrove afforestation and reforestation programmes in China. However, their capacity for carbon sequestration is still controversial. ResultsThe total vegetation biomass was highest in K. obovata monoculture, followed by the mixed forest and lowest in S. apetala monoculture. Such difference is attributed to the inconsistency by means of stem density of forests. This trend also applies to total vegetation and soil organic carbon storages. ConclusionsContrary to the original expectation, shrubby native K. obovata may be preferred to exotic S. apetala for mangrove carbon-based reforestation/afforestation prgrammes. It is recommended the carbon storage capacity of the existing S. apetala plantation may be enhanced by introducing native mangrove species. As an optional strategy of mangrove rehabilitation, the establishment of mixed plantations with different stem densities could improve the capacity of carbon storage for mono-specific plantations dominated by exotic species in Southern China.
Regional AET indicating oasis water consumption and groundwater dynamics under a background of climate change
Authors: Wu Lei , Changbin Li , Xie Xuhong , He Zhibin , Wang Wanrui , Zhang Yuan , Wei Jianmei , Lv Jianan 
Published: January 2020

Abstract
Background: Development of agriculture-dominated socio-economy have led to remarkable increase of water consumption in arid regions of the world. Frequent over-exploitation of water resources resulted in widely environmental degradation in the water-scarce and eco-fragile area, especially in China’s inland river basins. The Shiyang River Basin (SYRB) is the one where the most contradictive situation was found between socio-economic development and environmental sustainability in recent decades. In this study, a case study clarifying groundwater responses to intensive oasis water utilization was conducted during the time period from 1981 to 2010. Result: Regional AET was stepwise regressed with observed series of T, P and NDVI, the accuracy was found satisfactory. Module analysis revealed that the continuous warming had facilitated the AET rather than the other two factors (P and NDVI). The 30-year statistics revealed that total volume of oasis water utilization far exceeded mountainous discharges in the SYRB. Local abstractions offset the insufficiency and resulted in considerable drawdown of groundwater level. Dynamics of groundwater were found remarkably influenced by land surface water division, oasis scale and water consumption. Driven module calibrated upon regional averages of the above variables, suitable scale of the oasis was quantitatively discussed. Results revealed that the near-complete development of mountainous discharges, along with the over-exploitation of groundwater, have brought about degradation of the underground water system. Groundwater level drawdown showed annual rates of 0.17 m/a and 0.31 m/a in the middle and lower areas, respectively, during the time period from 1981 to 2010. Conclusions: Overexploitation of water resources and its negative consequences for regional hydrology and ecology in arid regions should be considered as a warning for pursuing economic well-being at the expense of the environment. Given the huge water demand for oasis survival and the background of climatic warming, reduction of arable scale combined with water transfer from outside should be conducted. This study serves as a 30-year case example when above contradictions presented remarkably in inland river systems in the arid northwestern China.
Are one-year changes in adherence to the 24-hour movement guidelines associated with depressive symptoms among youth?
Authors: Patte Karen A , Faulkner Guy , Qian Wei , Duncan Markus , Leatherdale Scott T. 
Published: January 2020

Abstract
Background There remains a need for prospective research examining movement behaviours in the prevention and management of mental illness. This study examined whether changes in adherence to the 24-hour movement guidelines (moderate-to-vigorous physical activity [MVPA], sleep duration, screen time) were associated with depression symptoms among youth.Methods Conditional change models were used to analyze two waves of longitudinal questionnaire data (2016/17, 2017/18) from students in grades 9-12 (N=2292) attending 12 schools in Ontario and British Columbia, Canada, as part of the COMPASS study. One-year change in adherence to the MVPA, screen time, and sleep duration guidelines were modeled as predictors of depressive symptoms, adjusting for covariates and prior year depressive symptoms. Models were stratified by sex.Results Continued adherence to sleep guidelines and transitioning from inadequate to sufficient sleep were associated with lower depressive symptoms than continued nonadherence, and continued adherence was associated with lower depression than transitioning from sufficient to short sleep. For screen time, transitioning from exceeding guidelines to guideline adherence was associated with lower depressive symptoms than continued nonadherence. MVPA guideline adherence was not associated with depression scores, when controlling for sleep and screen time guideline adherence change and covariates. When combined, meeting additional guidelines than the year prior was associated with lower depressive symptoms among females only.Conclusions Adherence to the sleep guidelines emerged as the most consistent predictor of depression symptoms. Promoting adherence to the movement guidelines, particularly sleep, should be considered priorities for youth mental health at a population level.
DMFT in Iranian 12-year-old students residing in the desert region and its association with their individual and family factors- 2016
Authors: Alami Ali , erfanpoor saeed , Ramezani Ali , Jafari Alireza 
Published: January 2020

Abstract
Introduction Oral health in students, as an important health-related subject, would be effective on their growth, self-confidence, socialization, learning ability, daily activities, and quality of life. The aim of this study was to evaluate the DMFT index of 12-year-old students in Gonabad and Bajistan and its relation with their personal and family factors.Methods An analytic-cross sectional study conducted among 1280 the students residing in the two desert districts of Iran in 2016. The required data including the subjects’ demographic and family factors as well as their oral health situation extracted from The National School Oral Health Program. The data entered in SPSS (20) and analyzed via Kruskal Wallis, Mann-Whitney, and logistic regression model.Findings Mean (SD) of the students’ DMFT was 1.47 (1.82). This index was calculated 0.98 (1.47) for boy students and 1.91 (1.98) for girl students (P<0.001). There were significant association between mean of the students’ DMFT and their residency location (P=0.015), birth rank (P=0.032), and level of education of their mothers (P=0.035).Conclusion According to the findings, attention to oral health in students, especially in girls, seems necessary. Increasing the knowledge and sensitivity of parents (especially mothers) concerning oral health of their children, especially their girls, the use of intermediate forces such healthcare providers in school and oral health technicians in health centers, and the implementation of preventive interventions such as fissure sealant, fluoride varnish Therapy, and use of sodium fluoride mouthwash by students would be effective for improving the oral health of students.
The prevalence of domestic violence and its correlation with family factors: A cross-sectional study among pregnant women in urban communities of Hengyang City, China
Authors: Zheng Baohua , Zhu Xidi , Hu Zhao , Zhou Wensu , Yu Yunhan , Yin Shilin , Xu Huilan 
Published: January 2020

Abstract
BackgroundDomestic violence (DV) against pregnant women is a serious public health problem that affects the health of the women’s children. This study aimed to explore the prevalence and correlation between family factors and DV among women in late pregnancy. MethodsA cross-sectional survey was conducted from July-October, 2019 among pregnant women in urban communities of Hengyang City, Hunan Province, China. A total of 813 participants were included by a multi-staged cluster random sampling method. DV was assessed by the Abuse Assessment Screen Questionnaire (AAS). A binary logistic regression model was used to evaluate the relationship between family factors and DV. ResultsUltimately, 127 (15.62%) participants were identified as victims of DV. After adjustment, the potential risk factors of DV were strained relations with their mother-in-law and other family members (OR: 6.59; 95% CI: 3.28 to 13.24 and OR: 6.32; 95% CI: 3.28 to 12.16), medium household debt (OR: 2.17; 95% CI: 1.22 to 3.85), separation (OR: 1.94; 95% CI: 1.19 to 3.14), partner’s extramarital relations (OR: 4.94; 95% CI: 1.19 to 13.58), and middle and low family APGAR (OR: 2.25; 95% CI: 1.47 to 3.46 and OR: 5.36; 95% CI: 2.95 to 9.76). ConclusionsIn summary, the correlation between DV and family factors may help medical personnel intervene in cases of domestic violence against pregnant women in a reasonable and timely manner.
Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population
Authors: Zhang Heng , Li Zhijuan , Wei Yarong , Fu Jinyan , Feng Yaling , Chen Daozhen , Xu De-xiang 
Published: January 2020

Abstract
Background：Vitamin D insufficiency and deficiency in childhood are common, and they are closely related to bone development. However, the status and influential factors of vitamin D during different ages are not clear. This study aimed to survey vitamin D status in children aged 0 to 6 years and explore its influential factors. Materials and methods: A total of 6953 children were recruited in Wuxi City of East China from January to December 2016. Enzyme-linked immunosorbent assay was used to determine the serum concentrations of 25-hydroxyvitamin D [25(OH)D]. Results: The median vitamin D level in the infancy group (0-1 years of age) was 69.40 nmol/L, which was higher than that in both the toddlerhood group (1-3 years of age; 62.30 nmol/L) and the preschool group (3-6 years of age; 50.85 nmol/L) (P < 0.001). In addition, the median vitamin D level was 71.70 nmol/L in summer, which was higher than that in spring (64.25 nmol/L), autumn (62.95 nmol/L) and winter (64.10 nmol/L; P < 0.001). However, no difference was observed between genders (P = 0.974). Furthermore, the prevalence of vitamin D deficiency (<50 nmol/L) was 48.1% in the preschool group (3-6 years of age), which was higher than the 21.2% vitamin D deficiency in the toddlerhood group (2-3 years of age) and the 17.9% vitamin D deficiency in the infancy group (0-1 years of age). Interestingly, a nonlinear association between 25(OH)D and air temperature was observed. Conclusions: A high prevalence of vitamin D deficiency was common in a Chinese population of children 0-6 years old, especially in the preschool-aged group. Season and air temperature were related to vitamin D status. Therefore, we suggest that the recommendation for vitamin D supplementation in the Chinese pediatric population should be revised to include older children and adolescents.