bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensity mapping as a probe of axion dark matter
Authors: Bauer Jurek B , Marsh David J E , Hložek Renée , Padmanabhan Hamsa , Laguë Alex 
Published: October 2020

ABSTRACT
We consider intensity mapping (IM) of neutral hydrogen (H i) in the redshift range 0 ≲ z ≲ 3 employing a halo model approach where H i is assumed to follow the distribution of dark matter (DM) haloes. If a portion of the DM is composed of ultralight axions, then the abundance of haloes is changed compared to cold DM below the axion Jeans mass. With fixed total H i density, $\Omega _{\rm H\, \rm {\small I}}$, assumed to reside entirely in haloes, this effect introduces a scale-independent increase in the H i power spectrum on scales above the axion Jeans scale, which our model predicts consistent with N-body simulations. Lighter axions introduce a scale-dependent feature even on linear scales due to its suppression of the matter power spectrum near the Jeans scale. We use the Fisher matrix formalism to forecast the ability of future H i surveys to constrain the axion fraction of DM and marginalize over astrophysical and model uncertainties. We find that a HIRAX-like survey is a very reliable IM survey configuration, being affected minimally by uncertainties due to non-linear scales, while the SKA1MID configuration is the most constraining as it is sensitive to non-linear scales. Including non-linear scales and combining a SKA1MID-like IM survey with the Simons Observatory CMB, the benchmark ‘fuzzy DM’ model with ma = 10−22 eV can be constrained at few per cent. This is almost an order of magnitude improvement over current limits from the Ly α forest. For lighter ULAs, this limit improves below 1 per cent, and allows the possibility to test the connection between axion models and the grand unification scale across a wide range of masses.
The physical origins of low-mass spin bias
Authors: Tucci Beatriz , Montero-Dorta Antonio D , Abramo L Raul , Sato-Polito Gabriela , Artale M Celeste 
Published: October 2020

ABSTRACT
At z = 0, higher-spin haloes with masses above $\log (M_{\text{c}}/h^{-1}\, \text{M}_\odot)\simeq 11.5$ have a higher bias than lower-spin haloes of the same mass. However, this trend is known to invert below this characteristic crossover mass, Mc. In this paper, we measure the redshift evolution and scale dependence of halo spin bias at the low-mass end and demonstrate that the inversion of the signal is entirely produced by the effect of splashback haloes. These low-mass haloes tend to live in the vicinity of significantly more massive haloes, thus sharing their large-scale bias properties. We further show that the location of the redshift-dependent crossover mass scale Mc(z) is completely determined by the relative abundance of splashbacks in the low- and high-spin subpopulations. Once splashback haloes are removed from the sample, the intrinsic mass dependence of spin bias is recovered. Since splashbacks have been shown to account for some of the assembly bias signal at the low-mass end, our results unveil a specific link between two different secondary bias trends: spin bias and assembly bias.
Diabetic Foot Infections: Local Prevalence of and Case–Control Study of Risk Factors for Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa
Authors: Kim Justin J , Lydecker Alison , Davé Rohini , Bork Jacqueline T , Roghmann Mary-Claire 
Published: October 2020

Abstract
We identified deep diabetic foot infections by culture and conducted a case–control study examining the risk factors for moderate to severe methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PsA) diabetic foot infections. Our MRSA prevalence was lower than literature values; PsA was higher. Gangrene may be predictive of Pseudomonas infection.
Development of an optical photon-counting imager with a monolithic Geiger Avalanche Photodiode array
Authors: Nakamori Takeshi , Ouchi Yuga , Ogihara Risa , Terasawa Toshio , Kato Yuhei , Shibata Shinpei 
Published: October 2020

Abstract
We have developed a sensor system based on an optical photon-counting imager with high timing resolution, aiming for highly time-variable astronomical phenomena. The detector is a monolithic Geiger-mode avalanche photodiode array customized in a Multi-Pixel Photon Counter with a response time on the order of nanoseconds. This paper evaluates the basic performance of the sensor and confirms the gain linearity, uniformity, and low dark count. We demonstrate the system’s ability to detect the period of a flashing light-emitting diode, using a data acquisition system developed to obtain the light curve with a time bin of 100 μs. The Crab pulsar was observed using a 35-cm telescope without cooling, and the equipment detected optical pulses with a period consistent with the data from the radio ephemeris. Although improvements to the system will be necessary for more reliability, the system has been proven to be a promising device for exploring the time-domain optical astronomy.
Skin microvascular dysfunction in systemic lupus erythematosus patients with and without cardiovascular risk factors
Authors: Koletsos Nikolaos , Gkaliagkousi Eugenia , Lazaridis Antonios , Triantafyllou Areti , Anyfanti Panagiota , Dolgyras Panagiotis , Dipla Konstantina , Galanopoulou Vasiliki , Aslanidis Spyros , Douma Stella 
Published: October 2020

Abstract

Objectives
Patients with SLE have increased cardiovascular mortality. Alterations in both macro- and micro-circulation have been associated with cardiovascular disease. We sought to assess skin microvascular function by using laser speckle contrast analysis (LASCA) in patients with SLE, with and without cardiovascular disease and risk factors.

Methods
Continuous blood flow was recorded using a LASCA device during baseline, a 5-min arterial occlusion and a 5-min reperfusion period.

Results
Thirty-five patients with SLE (85.7% women) with a median disease duration 12.0 (6.5–17.5) years and a mean age of 46.3 (8.6) years and 31 controls matched for age, sex and BMI were enrolled. During reperfusion, SLE patients exhibited a smaller peak magnitude compared with controls (161.0 (47.1) vs 197.2 (41.4)%, respectively, P =0.002). Results remained unchanged among 24 SLE patients without cardiovascular disease compared with the control group (169.2 (48.1) vs 195.6 (34.0)%, respectively, P =0.002).

Conclusion
Our study shows, for the first time, that patients with SLE, even without overt cardiovascular disease or risk factors, exhibit a blunted microvascular reactivity during reperfusion compared with controls. These results show that skin microvascular dysfunction is present in SLE independently of the CV burden that these patients bear and may represent an early sign of vascular damage.
Race and Ethnicity in the Social Work Grand Challenges
Authors: Rao Smitha , Woo Bongki , Maglalang Dale Dagar , Bartholomew Melissa , Cano Manuel , Harris Abril , Tucker Ty B 
Published: October 2020

Abstract
Race, ethnicity, and racism (RER) are interconnected with the critical problems tackled in the Grand Challenges for Social Work (GCSW). Yet, the extent to which the GCSW discuss the central role of RER is less clear. This article investigates how the GCSW integrate RER in their discourse. Using content analysis, authors examined all 21 concept papers that comprise the 12 initial GCSW to determine their attention to RER. Authors assessed whether each paper made any reference to race or ethnicity, whether race or ethnicity was considered as a primary theme, and whether racism was mentioned. Nine GCSW had at least one paper that mentioned race or ethnicity; seven had at least one paper that treated race and ethnicity as a major construct. Five GCSW contained at least one paper that discussed racism’s impacts on their topical interests. None of the papers analyzed in the study defined or specified their conceptualization of racism. The GCSW are strategically positioned to widen and deepen social work’s focus on RER, and the recent adoption of the 13th GCSW to “Eliminate racism” is an important first step. Authors encourage the social work field to embrace a more explicit, renewed, and continued commitment to eradicating systemic racism.
Wood properties and transcriptional responses of poplar hybrids in mixed cropping with the nitrogen-fixing speciesRobinia pseudoacacia
Authors: Euring Dejuan , Janz Dennis , Polle Andrea 
Published: October 2020

AbstractCultivation of fast-growing tree species is often confined to marginal land. Mixed cropping with Robinia pseudoacacia, a legume tree species that forms a symbiosis with N2-fixing bacteria, has been proposed to be a measure to improve soil fertility and to achieve beneficial effects on the cocultivated tree species. The goal of our study was to examine the influence of a Robinia mixture on wood chemistry, anatomy and gene expression in poplar. We hypothesized that annual wood growth is stimulated in species mixtures due to the positive effects of Robinia on nitrogen availability and complementary resource use. Alternatively, we hypothesized that competition, especially for water, has negative effects on the wood growth of poplar. We used two commercial biomass clones, Hybride 275 (H275, Populus trichocarpa × Populus maximowiczii) and Max1 (Populus nigra × P. maximowiczii), which were planted at two locations with contrasting soil fertility in monoculture or mixed plots with Robinia to investigate the annual wood increment, wood nitrogen and δ13C, wood anatomy (length, cell wall thickness, lumina and frequencies of fibers and vessels) and transcriptional profiles in the developing xylem of 4-year-old stems. In a mixture with Robinia, the annual stem increment was reduced, nitrogen in wood was enhanced, δ13C in wood was decreased, vessel and fiber frequencies were increased and fiber lengths and fiber lumina were decreased. Transcriptional profiles showed stronger differences between the genotypes and sites than between mono and mixed cultivation. The transcriptional abundances of only one gene (the putative nitrate transporter, NRT1.2) and one gene ontology term (‘immune system process’) were significantly enriched in wood-forming tissues in response to the mixture, irrespective of the poplar genotype and growth location. Weighted gene coexpression network analyses extracted gene modules that linked wood nitrogen mainly to vessel traits and wood δ13C with fiber traits. Collectively, molecular and anatomical changes in poplar wood suggest beneficial effects on the water and N supply in response to the mixture with Robinia. These alterations may render poplars less drought-susceptible. However, these benefits are accompanied by a reduced wood increment, emphasizing that other critical factors, presumably light competition or allelopathic effects, overrule a potential growth stimulation.
Surgical Elbow Dislocation Approach to the Distal Humerus for Apparent Capitellar and Lateral Condyle Fractures in Adults
Authors: Hoyt Benjamin W. , Clark DesRaj M. , Walsh Sarah A. , Pensy Raymond A. 
Published: October 2020

Objectives:
Access to fractures of the distal humeral capitellum, trochlea, and lateral condyle is difficult through traditional approaches due to limited anterior articular exposure for direct reduction and fixation. The purpose of this study is to evaluate the relative articular exposure of a surgical dislocation (SD) approach to the distal humerus compared with olecranon osteotomy (OO).

Methods:
Eight paired elbows from 4 cadavers underwent either SD or OO approach. Methylene blue staining demarcated visualized articular surface before disarticulation of the elbows. The main outcome measures were average visualized total distal humeral articular surface and anterior and posterior surface, and capitellar surface relative to the total surfaces was compared for each surgical approach using unpaired parametric t-tests.

Results:
Intraclass correlation between raters was 0.995. The median exposed articular surface for SD and OO approaches was 90.0% and 62.8%, respectively. The overall exposure was significantly greater for the dislocation technique (P = 0.0003). With respect to specific regions of the distal humeral articular surface, SD allowed significantly greater visualization of the anterior surface (95.9% vs. 48.9%, P < 0.0001) and capitellum (100% vs. 40.4%, P < 0.0001).

Conclusion:
The surgical elbow dislocation approach to the distal humerus permits near total exposure of the anterior articular surface and the entire capitellum. Our data support this approach for anterior articular fractures of the distal humerus, to include those fractures that extend to the medial surface of the trochlea.
A Multicenter Observational Study on the Postoperative Outcomes of C3 Laminectomy in Cervical Double-door Laminoplasty
Authors: Nakajima Koji , Nakamoto Hideki , Kato So , Doi Toru , Matsubayashi Yoshitaka , Taniguchi Yuki , Yoshida Yuichi , Kawamura Naohiro , Nakarai Hiroyuki , Higashikawa Akiro , Tozawa Keiichiro , Takeshita Yujiro , Fukushima Masayoshi , Iizuka Masaaki , Ono Takashi , Shirokoshi Tomohiko , Azuma Seiichi , Tanaka Sakae , Oshima Yasushi 
Published: October 2020

Study Design:
Multicenter retrospective observational study.

Objective:
To determine the differences between C3 laminectomy (LN) and C3 laminoplasty (LP) in cervical LP.

Summary of Background Data:
Interlaminar bony fusion after cervical LP is reported to be related to a decrease in postoperative range of motion (ROM) or neurological disorder. However, it remains uncertain whether C3 LN affects patient-reported outcomes, especially after double-door LPs. Therefore, this study aimed to investigate the effect of C3 LN compared with C3 LP in cervical double-door LP.

Patients and Methods:
Using our prospective database, consecutive patients with degenerative cervical myelopathy undergoing cervical double-door LP in 7 hospitals between April 2017 and May 2018 were enrolled. Before and 1 year after the surgeries, we collected the details of patient background data, operative factors, radiologic findings such as C2–C7 ROM angle and C2–C3 interlaminar bony fusion, the Japanese Orthopaedic Association (JOA) score, postoperative satisfaction, neck pain, and patient-reported outcomes such as Short Form-12 (SF-12), EuroQol 5 Dimension (EQ-5D), Neck Disability Index (NDI), and the Core Outcome Measures Index (COMI) for the neck.

Results:
In all, 152 patients were enrolled, including 97 undergoing C3 LP and 55 undergoing C3 LN. There were no significant differences in patient background data, complications, and operative factors. C2–C3 interlaminar bony fusion occurred more often in the C3 LP group (22.6% vs. 5.7%). There were also no differences in the C2–C7 angle, C2–C7 ROM angle, the JOA score, patient satisfaction, neck pain, SF-12, EQ-5D, NDI, and COMI between the groups.

Conclusions:
C2–C3 bony fusion after cervical double-door LP occurred more often in the C3 LP group than in the C3 LN group. C3 LN resulted in similar outcomes in complication rate, radiographic outcomes, and clinical outcomes compared with those of C3 LP.

Level of Evidence:
Level III.
HTRA1-related autosomal dominant cerebral small vessel disease
Authors: Liu Jing-Yi , Zhu Yi-Cheng , Zhou Li-Xin , Wei Yan-Ping , Mao Chen-Hui , Cui Li-Ying , Peng Bin , Yao Ming 
Published: October 2020

Abstract

Background
Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (HTRA1) gene are responsible for cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Recently, increasing evidence has shown that heterozygous HTRA1 mutations are also associated with cerebral small vessel disease (CSVD) with an autosomal dominant pattern of inheritance. This study was aimed to analyze the genetic and clinical characteristics of HTRA1-related autosomal dominant CSVD.

Methods
We presented three new Chinese cases of familial CSVD with heterozygous HTRA1 mutations and reviewed all clinical case reports and articles on HTRA1-related autosomal dominant CSVD included in PUBMED by the end of March 1, 2020. CARASIL probands with genetic diagnosis reported to date were also reviewed. The genetic and clinical characteristics of HTRA1-related autosomal dominant CSVD were summarized and analyzed by comparing with CARASIL.

Results
Forty-four HTRA1-related autosomal dominant CSVD probands and 22 CARASIL probands were included. Compared with typical CARASIL, HTRA1-related autosomal dominant probands has a higher proportion of vascular risk factors (P < 0.001), a later onset age (P < 0.001), and a relatively slower clinical progression. Alopecia and spondylosis can be observed, but less than those in the typical CARASIL. Thirty-five heterozygous mutations in HTRA1 were reported, most of which were missense mutations. Amino acids located close to amino acids 250–300 were most frequently affected, followed by these located near 150∼200. While amino acids 250∼300 were also the most frequently affected region in CARASIL patients, fewer mutations precede the 200th amino acids were detected, especially in the Kazal-type serine protease domain.

Conclusions

HTRA1-related autosomal dominant CSVD is present as a mild phenotype of CARASIL. The trend of regional concentration of mutation sites may be related to the concentration of key sites in these regions which are responsible for pathogenesis of HTRA1-related autosomal dominant CSVD.
Differential lung ventilation assessed by electrical impedance tomography in ultrasound-guided anterior suprascapular nerve block vs. interscalene brachial plexus block
Authors: Petroff David , Wiegel Martin , Pech Virginia , Salz Peter , Mrongowius Julia , Reske Andreas W. 
Published: October 2020

BACKGROUND
Ultrasound-guided interscalene brachial plexus block (ISB) is used to control pain after shoulder surgery. Though effective, drawbacks include phrenic nerve block and motor block of the hand. The ultrasound-guided anterior approach to perform suprascapular nerve block (SSNB) may provide a good alternative.

OBJECTIVE
To compare lung ventilation and diaphragmatic activity on the operated side in ISB and SSNB.

DESIGN
Randomised, controlled patient-blinded and assessor-blinded trial.

SETTING
Outpatient surgical clinic with recruitment from June 2017 to January 2018.

PATIENTS
Fifty-five outpatients scheduled for arthroscopic shoulder surgery were allocated randomly to receive SSNB or ISB. Technical problems with monitoring devices unrelated to the intervention led to exclusion of seven patients. The remaining 48 (n=24 in each group) were followed up for 24 h without drop-outs.

INTERVENTIONS
Patients received 10 ml of ropivacaine 1.0% wt/vol for both procedures.

OUTCOME MEASURES
Percentage lung ventilation on the operated side was the primary endpoint as assessed with electrical impedance tomography (EIT). Secondary endpoints were hemidiaphragmatic motion on the operated side, pain, opioid use, hand strength and numbness, and patient satisfaction.

RESULTS
Before regional anaesthesia, the lung on the operated side contributed a median [IQR] of 50 [42 to 56]% of the total lung ventilation. Postoperatively, it was 40 [3 to 50]% (SSNB) vs. 3 [1 to 13]% (ISB) for an adjusted difference of 23 (95% CI, 13 to 34)%, (P < 0.001). Hemidiaphragmatic motion was 1.90 (95% CI, 1.37 to 2.44 cm), (P < 0.001) lower in the ISB group compared with the SSNB group. Hand strength was 11.2 (95% CI 3.6 to 18.9), (P = 0.0024) kg greater for SSNB and numbness was observed in 0% (SSNB) vs. 46% (ISB) of patients, P < 0.001. Pain was low in the first 6 h after surgery in both groups with slightly, but not significantly, lower values for ISB. No meaningful or significant differences were found for opioid use or patient satisfaction.

CONCLUSION
An ultrasound-guided anterior approach to SSNB preserves ipsilateral lung ventilation and phrenic function better than a standard ISB.

TRIAL REGISTRATION
drks.de identifier: DRKS00011787.
Role of Stem Cell–Derived Microvesicles in Cardiovascular Disease
Authors: Kraus Lindsay , Mohsin Sadia 
Published: October 2020

Abstract:
The role of stem cells in augmenting reparative processes in the heart after ischemic injury has been successfully demonstrated in small and large animal models. However, the outcomes of cell therapy in clinical trials have been somewhat variable, with overall effects of autologous stem cell therapies demonstrating a modest improvement in cardiac structure and function. How stem cells repair the heart after cardiac injury is still not well understood. Most recent studies suggest that adult derived stem cells act primarily through paracrine signaling to exert beneficial effects, including modulation of immune response, stimulation of new blood vessel formation, or by inducing mature myocytes to transiently reenter the cell cycle, rather than robust direct differentiation of the transplanted cells into myocytes. In addition, data from multiple laboratory results confirmed clearance of stem cells themselves within a few days still leading to functional benefits further confirming the role of paracrine signaling in augmenting cardiac reparative processes rather than direct differentiation of cells. These findings rapidly evolved the field of extracellular vesicles specifically microvesicles (MVs) as they are active hubs of autocrine, paracrine, and endocrine signaling targeting different biological processes. The beneficial effects seen after stem cell transplantation could be linked to the cardioprotective factors packaged in the MVs secreted from stem cells. Therefore, stem cell MVs provide a new avenue for the treatment of cardiovascular disease through a multitude of mechanisms including cellular communication within the stem cell niches, delivery of genetic information, regulation of the immune system in the heart, and stimulation of angiogenesis which will be discussed in this review.
Effects of Carvedilol and Thyroid Hormones Co-administration on Apoptotic and Survival Proteins in the Heart After Acute Myocardial Infarction
Authors: Ortiz Vanessa Duarte , Türck Patrick , Teixeira Rayane , Belló-Klein Adriane , de Castro Alexandre Luz , Araujo Alex Sander da Rosa 
Published: October 2020

Abstract:Cellular death and survival signaling plays a key role in the progress of adverse cardiac remodeling after acute myocardial infarction (AMI). Therapeutic strategies, such as co-treatment with beta-blocker carvedilol and thyroid hormones (THs), give rise to new approaches that can sustain the cellular homeostasis after AMI. Therefore, we sought to investigate the effects of carvedilol and TH co-administration on apoptosis and survival proteins and on cardiac remodeling after AMI. Male Wistar rats were distributed in 5 groups as follows: sham-operated group (SHAM), infarcted group (MI), infarcted plus carvedilol group (MI+C), infarcted plus TH group (MI+TH), and infarcted plus carvedilol and TH co-treatment group (MI+C+TH). Echocardiographic analysis was performed, and hearts were collected for western blot evaluation. The MI group presented systolic posterior wall thickness loss, an increase in the wall tension index, and an increase in atrial natriuretic peptide tissue levels than the SHAM group. However, in the MI+C+TH group, these parameters were equally to the SHAM group. Moreover, whereas the MI group showed Bax protein expression elevated in relation to the SHAM group, the MI+C+TH group presented Bax reduction and also Akt activation compared with the MI group. In addition, the MI+TH group revealed beta-1 adrenergic receptor (β1AR) upregulation compared with the MI and MI+C groups, whereas the MI+C+TH group presented lower levels of β1AR in relation to the SHAM and MI+TH groups. In conclusion, we suggest that carvedilol and TH co-administration may mediate its cardioprotective effects against adverse cardiac remodeling post-AMI through the Bax reduction, Akt activation, and β1AR decrease.