bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinct tissue injury patterns in juvenile dermatomyositis auto-antibody subgroups
Authors: Nguyen Mailan , Do Vy , Yell Paul C. , Jo Chanhee , Liu Jie , Burns Dennis K. , Wright Tracey , Cai Chunyu 
Published: August 2020

Abstract
Introduction
Juvenile dermatomyositis (JDM) can be classified into clinical serological subgroups by distinct myositis-specific antibodies (MSAs). It is incompletely understood whether different MSAs are associated with distinct pathological characteristics, clinical disease activities, or response to treatment.

Methods
We retrospectively reviewed clinicopathological data from consecutive JDM patients followed in the pediatric rheumatology clinic at a single center between October 2016 and November 2018. Demographics, clinical data, and laboratory data were collected and analyzed. Detailed muscle biopsy evaluation of four domains (inflammation, myofiber, vessels, and connective tissue) was performed, followed by statistical analysis.

Results
Of 43 subjects included in the study, 26 (60.5%) had a detectable MSA. The most common MSAs were anti-NXP-2 (13, 30.2%), anti-Mi-2 (7, 16.3%), and anti-MDA-5 (5, 11.6%). High titer anti-Mi-2 positively correlated with serum CK > 10,000 at initial visit (r = 0.96, p = 0.002). Muscle biopsied from subjects with high titer anti-Mi-2 had prominent perifascicular myofiber necrosis and perimysial connective tissue damage that resembled perifascicular necrotizing myopathy, but very little capillary C5b-9 deposition. Conversely, there was no positive correlation between the levels of the anti-NXP-2 titer and serum CK (r = − 0.21, p = 0.49). Muscle biopsies from patients with anti-NXP-2 showed prominent capillary C5b-9 deposition; but limited myofiber necrosis. Only one patient had anti-TIF1γ autoantibody, whose muscle pathology was similar as those with anti-NXP2. All patients with anti-MDA-5 had normal CK and near normal muscle histology.

Conclusions
Muscle biopsy from JDM patients had MSA specific tissue injury patterns. These findings may help improve muscle biopsy diagnosis accuracy and inform personalized treatment of JDM.
How should researchers cope with the ethical demands of discovering research misconduct? Going beyond reporting and whistleblowing
Authors: Vie Knut Jørgen 
Published: August 2020

AbstractIn this paper, I will argue that making it mandatory to report research misconduct is too demanding, as this kind of intervention can at times be self-destructive for the researcher reporting the misconduct. I will also argue that posing the question as a binary dilemma masks important ethical aspects of such situations. In situations that are too demanding for individual researchers to rectify through reporting, there can be other forms of social control available. I will argue that researchers should explore these. Finally, framing the issue as a question about the responsibilities of individual researchers masks the responsibilities of research institutions. Until institutions introduce measures that make this safe and effective, we should not consider reporting research misconduct mandatory. I will discuss this in light of both quantitative and qualitative data gathered as part of a survey in the PRINTEGER-project.
Web Application for the Automated Extraction of Diagnosis and Site From Pathology Reports for Keratinocyte Cancers
Authors: Thompson Bridie S. , Hardy Sam , Pandeya Nirmala , Dusingize Jean Claude , Green Adele C. , Millane Athon , Bourke Daniel , Grande Ronald , Bean Cameron D. , Olsen Catherine M. , Whiteman David C. 
Published: August 2020

PURPOSE Keratinocyte cancers are exceedingly common in high-risk populations, but accurate measures of incidence are seldom derived because the burden of manually reviewing pathology reports to extract relevant diagnostic information is excessive. Thus, we sought to develop supervised learning algorithms for classifying basal and squamous cell carcinomas and other diagnoses, as well as disease site, and incorporate these into a Web application capable of processing large numbers of pathology reports. METHODS Participants in the QSkin study were recruited in 2011 and comprised men and women age 40-69 years at baseline (N = 43,794) who were randomly selected from a population register in Queensland, Australia. Histologic data were manually extracted from free-text pathology reports for participants with histologically confirmed keratinocyte cancers for whom a pathology report was available (n = 25,786 reports). This provided a training data set for the development of algorithms capable of deriving diagnosis and site from free-text pathology reports. We calculated agreement statistics between algorithm-derived classifications and 3 independent validation data sets of manually abstracted pathology reports. RESULTS The agreement for classifications of basal cell carcinoma (κ = 0.97 and κ = 0.96) and squamous cell carcinoma (κ = 0.93 for both) was almost perfect in 2 validation data sets but was slightly lower for a third (κ = 0.82 and κ = 0.90, respectively). Agreement for total counts of specific diagnoses was also high (κ > 0.8). Similar levels of agreement between algorithm-derived and manually extracted data were observed for classifications of keratoacanthoma and intraepidermal carcinoma. CONCLUSION Supervised learning methods were used to develop a Web application capable of accurately and rapidly classifying large numbers of pathology reports for keratinocyte cancers and related diagnoses. Such tools may provide the means to accurately measure subtype-specific skin cancer incidence.
Metastatic Pancreatic Cancer: ASCO Guideline Update
Authors: Sohal Davendra P.S. , Kennedy Erin B. , Cinar Pelin , Conroy Thierry , Copur Mehmet S. , Crane Christopher H. , Garrido-Laguna Ignacio , Lau Michelle W. , Johnson Tyler , Krishnamurthi Smitha , Moravek Cassadie , O’Reilly Eileen M. , Philip Philip A. , Pant Shubham , Shah Manish A. , Sahai Vaibhav , Uronis Hope E. , Zaidi Neeha , Laheru Daniel 
Published: August 2020

PURPOSE The aim of this work was to provide an update to the ASCO guideline on metastatic pancreatic cancer pertaining to recommendations for therapy options after first-line treatment. METHODS ASCO convened an Expert Panel and conducted a systematic review to update guideline recommendations for second-line therapy for metastatic pancreatic cancer. RESULTS One randomized controlled trial of olaparib versus placebo, one report on phase I and II studies of larotrectinib, and one report on phase I and II studies of entrectinib met the inclusion criteria and inform the guideline update. RECOMMENDATIONS New or updated recommendations for germline and somatic testing for microsatellite instability high/mismatch repair deficiency, BRCA mutations, and TRK alterations are provided for all treatment-eligible patients to select patients for recommended therapies, including pembrolizumab, olaparib, larotrectinib, or entrectinib, or potential clinical trials. The Expert Panel continues to endorse the remaining recommendations for second-line chemotherapy, as well as other recommendations related to treatment, follow-up, and palliative care from the 2018 version of this guideline. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .
Effect of Rotational Modulation on Rayleigh – B´enard Convection in a Couple Stress Liquid
Authors: Pranesh S , K Sangeetha George 
Published: August 2020

The Rayleigh-B´enard convection in a couple stress liquid with rotational modulation is studied using the linear analysis based on normal mode technique. The stability of a horizontal layer of fluid heated from below is examined when, in addition to a steady rotation, a time-periodic sinusoidal perturbation is applied. The expression for Rayleigh number and correction Rayleigh number are obtained using regular perturbation method. The expression for correction Rayleigh number is obtained as a function of frequency of modulation, Taylor number, Couple Stress parameter and Prandtl number. It is observed that rotational modulation leads to delay in onset of convection. Rotation modulation is an example of external control of internal convection.
Kekerasan Anak dalam Keluarga
Authors: Kadir Abdul , Handayaningsih Anik 
Published: August 2020

Abstrak Keluarga memiliki peran dan fungsi yang cukup besar terhadap perkembangan dan masa depan anak. Seorang anak harus mendapatkan kesempatan yang seluas-luasnya untuk dapat tumbuh dan berkembang secara optimal baik fisik, psikis, sosial, maupun spiritual. Anak juga perlu mendapatkan hak-haknya untuk dilindungi dan disejahterakan serta Segala bentuk tindak kekerasan terhadap anak perlu dicegah dan diatasi khususnya kekerasan fisik terhadap anak. Kekerasan dalam rumah tangga merupakan aktifitas di mana pelaku (yang merupakan anggota rumah tangga) menyerang seseorang yang juga merupakan anggota dari rumah tangga tersebut. Kekerasan terhadap anak berarti kekerasan yang dilakukan oleh orang tua terhadap anaknya. Kesadaran orang tua mengenai dampak buruk dari hukuman kekerasan masihlah rendah, hal ini dipengaruhi adanya banyak faktor seperti kurangya pengetahuan mengenai kekerasan, adanya tradisi kekerasan, hingga masalah psikologis. Namun pada umumnya orang tua merasa bahwa kekerasan merupakan satu-satunya solusi untuk mengasuh dan mendidik anak. Tujuan penelitian adalah untuk mengetahui bentuk kekersan fisik terhadap anak yang dilakukan oleh orangtua. Peneltian ini menggunakan Kajian literatur dengan data yang diperoleh dari jurnal, buku, dan internet. Hasil dari dari artikel ini meliputi dari pewarisan kekerasan antar generasi, kekerasan terhadap anak dalam keluarga sulit terungkap di ruang publik, dan latar belakang budaya (Adanya hubungan kedudukukan dalam masyarakat yang selalu menempatkan anak dalam posisi terbawah). Kata Kunci : Orang tua, Anak, Kekerasan, Keluarga
İroni ve Gerilim: İkinci Dünya Savaşı Yıllarında İstanbul’da ve Ankara’da Savaş Algısı (Irony and Tension: Perception of War in Istanbul and Ankara during the Second World War Years), Sinan Niyazioğlu1 (2016)
Authors: Barbosa Helena 
Published: August 2020

Review of: İroni ve Gerilim: İkinci Dünya Savaşı Yıllarında İstanbul’da ve Ankara’da Savaş Algısı (Irony and Tension: Perception of War in Istanbul and Ankara during the Second World War Years), Sinan Niyazioğlu (2016)
Ankara, Turkey: Vekam, 312 pp.,
ISBN 978-6-05938-806-1, p/bk, €8
Hepatitis C Virus Clearance by Direct-Acting Antivirals Agents Improves Endothelial Dysfunction and Subclinical Atherosclerosis: HEPCAR Study
Authors: Muñoz-Hernández Rocío , Ampuero Javier , Millán Raquel , Gil-Gómez Antonio , Rojas Ángela , Macher Hada C. , Gallego-Durán Rocío , Gato Sheila , Montero-Vallejo Rocío , Rico María C. , Maya-Miles Douglas , Sánchez-Torrijos Yolanda , Soria Isabel Carmona , Stiefel Pablo , Romero-Gómez Manuel 
Published: August 2020

INTRODUCTION:
Hepatitis C virus (HCV) infection has been related to increased cardiovascular (CV) risk. The aim of this study was to analyze the impact of sustained virological response (SVR) on endothelial dysfunction and subclinical atherosclerosis in patients with hepatitis C virus treated with direct-acting antiviral agents.

METHODS:
A total of 114 patients were prospectively recruited and underwent CV risk assessment including (i) endothelial dysfunction determined through laser Doppler flowmetry and (ii) subclinical atherosclerosis, elucidated by the ankle-brachial index (ABI). Atherogenic lipid profile (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides); markers of oxidative stress (oxidized low-density lipoprotein antibodies [OLAbs]), soluble markers of adhesion (vascular cell adhesion molecule [VCAM], e-selectin, and soluble markers of angiogenesis; and vascular endothelial growth factor, endothelial [EMPs] and platelet [PMPs] apoptotic microparticles, and cell-free DNA [cfDNA]) were measured. All determinations were performed at baseline, 12 weeks (SVR time), and 1 year after treatment.

RESULTS:
In patients with endothelial dysfunction, area of hyperemia improved after virus clearance (P = 0.013) and was related to significant decrease in VCAM, e-selectin (P < 0.001), and cfDNA (P = 0.017) and to increased OLAb levels (P = 0.001). In patients with subclinical atherosclerosis at baseline, a significantly improved ABI was seen after HCV clearance (P < 0.001). Levels of both EMPs and PMPs also decreased after SVR and at follow-up (P = 0.006 and P = 0.002, respectively).

DISCUSSION:
HCV clearance improved not only liver function but also endothelial dysfunction and subclinical atherosclerosis promoted by decrease in levels of VCAM, e-selectin, cfDNA, and PMPs and EMPs.
Comparing Clinical, Imaging, and Physiological Correlates of Intestinal Pseudo-Obstruction: Systemic Sclerosis vs Amyloidosis and Paraneoplastic Syndrome
Authors: Pamarthy Rahul , Berumen Antonio , Breen-Lyles Margaret , Grover Madhusudan , Makol Ashima 
Published: August 2020

INTRODUCTION:
Intestinal pseudo-obstruction is characterized by impaired transit and luminal dilation in the absence of mechanical obstruction. Our study aims to describe the clinical, radiographic, and physiological findings in pseudo-obstruction associated with systemic sclerosis (SSc), amyloidosis, and paraneoplastic syndrome.

METHODS:
A retrospective cohort of patients evaluated at our institution between January 1, 2008, and August 1, 2018, was assembled. Clinical, imaging, and physiological characteristics were abstracted from electronic medical records.

RESULTS:
We identified 100 cases of pseudo-obstruction (55 SSc, 27 amyloidosis, and 18 paraneoplastic). Female population predominance was seen in SSc (71%) vs male population in amyloidosis (74%). Most common symptom was abdominal bloating in all 3 groups. Vomiting was more common in SSc than amyloidosis (73% vs 46%, P = 0.02). Diarrhea was more common in amyloidosis and SSc compared with paraneoplastic (81% and 67% vs 28%, P < 0.01). Weight loss (>5%) was more common in SSc compared with amyloidosis and paraneoplastic (78% vs 31% and 17%, P < 0.0001). Only small bowel dilation was seen in 79%, 40%, and 44% and only large bowel dilation in 2%, 44%, and 44% of patients in SSc, amyloidosis, and paraneoplastic, respectively. Five of 8 SSc patients had myopathic and 3 of 5 paraneoplastic had neuropathic involvement on gastroduodenal manometry.

DISCUSSION:
SSc-associated pseudo-obstruction demonstrates female population predominance and presents with vomiting, diarrhea, and weight loss. Amyloidosis-associated pseudo-obstruction shows male population predominance. Small bowel is more commonly involved than large bowel on both imaging and transit studies in SSc. Myopathic involvement was more common in SSc, contrary to neuropathic in paraneoplastic syndrome.
Gênero e escola do campo
Authors: Pessoa Rodrigues Vânia Maria , Cabral Marinho dos Santos Simone , Mesquita Soares Themis Cristina 
Published: August 2020

Esse artigo tem como objetivo analisar o perfil das profissionais docentes que atuam na escola do campo em um contexto local da região semiárida potiguar. Aborda-se o lugar do gênero feminino na escola, no sentido de estabelecer uma correlação com a luta das mulheres na conquista de espaço social. Trata-se de um estudo misto, ao combinar as pesquisas bibliográfica e documental, se utilizando das abordagens quantitativa e qualitativa, realizada nas escolas do campo municipais de ensino fundamental – séries iniciais, de um município de pequeno porte da região semiárida potiguar. Os dados coletados revelaram questões importantes e também preocupantes. Uma educação marcada pela presença do feminino 62% do total, com atuação polivalente, observou-se quadro de professores provisórios (32%), com baixos salários e pouca valorização do profissional que atua na escola do campo. O trabalho docente, de caráter provisório, representa uma exploração do feminino mascarado por um subemprego. Porém, a presença de mulheres na escola do campo demonstra a emancipação de mulheres que assume o compromisso de contribuir para a superação das relações opressivas e de discriminação da sociedade.
ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI PARTISIPASI PETANI DALAM ASURANSI USAHATANI PADI (AUTP) DI KECAMATAN PENEBEL KABUPATEN TABANAN
Authors: Suindah Ni Nyoman , Darmawan Dwi Putra , Suamba I Ketut 
Published: August 2020

Sejak tahun 2015 pelaksanaan AUTP diberlakukan di Indonesia, salah satunya di Kecamatan Penebel yang merupakan kecamatan dengan hamparan sawah terluas di Kabupaten Tabanan yaitu 3.894 Ha. Subak Keloncing dan Subak Piak merupakan dua subak yang berlokasi di Desa Wongaya Gede Kecamatan Penebel. Subak Keloncing merupakan peserta program AUTP sedangkan Subak Piak bukan peserta program AUTP. Berada di lokasi yang sama namun kedua subak ini memiliki keputusan yang berbeda dalam partisipasi program AUTP sehingga menarik untuk dilakukan penelitian mengenai faktor-faktor yang memengaruhi partisipasi petani dalam asuransi usahatani padi (AUTP) di Kecamatan Penebel Kabupaten Tabanan. Faktor-faktor yang memengaruhi partisipasi petani dalam program AUTP dianalisis menggunakan regresi logistik biner (binary logistic regression). Petani responden memiliki karakteristik seperti pada petani pada umumnya, hanya saja petani responden mayoritas adalah petani gurem. Terdapat empat faktor yang memengaruhi partisipasi petani dalam program AUTP yaitu sikap terhadap perubahan, gaya kepemimpinan pekaseh, metode sosialisasi program AUTP dan peran keaktifan PT. Jasindo dalam progarm AUTP. Diperlukan upaya lebih lanjut mengenai sosialisasi kepada petani yang belum berpartisipasi dalam program dan pemerintah diharapkan membuat suatu wadah untuk menampung aspirasi petani mengenai kekurangan maupun kelebihan program AUTP sebagai bahan evaluasi.
PERBANDINGAN KUALITAS PRODUK DAN MINAT MENABUNG PADA LPD DESA ADAT TAJUN DENGAN DESA ADAT TEGAL
Authors: Luh Eka Swarnadi , Susrusa Ketut Budi , Listia Dewi Ida Ayu 
Published: August 2020

LPDs are non-bank financial institutions that are regulated and approved by the Regional Regulations of the Province of Bali. The management of LPD is fully handed over to the relevant Pakraman village. In line with the rapid development of LPDs, it turns out that on the other hand it shows diverse performance, so that LPDs need to pay attention to the level of product quality and customer interest in the products offered. The purpose of the study was to determine the comparison of product quality and interest in saving at the Tajun Traditional Village LPD with the Traditional Village of Tegal. The number of samples from Tajun Adat Village LPD was 98 people and the LPD of Tegal Traditional Village was 84 people. The research data were analyzed by the Mann-Whitney Test. The results showed that there was a significant difference between the quality of the products of the Adat Village of Tajun LPD and the Traditional Village of Tegal. This difference is indicated by indicators of physical evidence, reliability, responsiveness and empathy. The product quality of Tajun Adat Village's LPD is better than the traditional village of Tegal. There is a significant difference between the interest in saving the traditional village of Tajun LPD and the traditional village of Tegal. The difference is in the indicator of confidence. Interest in Saving Tajun Indigenous Village LPD is higher than the Traditional Village of Tegal.
ANALISIS KEPUASAN KONSUMEN DAN STRATEGI PENGEMBANGAN AGROWISATA KEBUN BUAH CEPOKO DI KECAMATAN GUNUNG PATI KOTA SEMARANG
Authors: Sembiring Yanti Yosepha Rufina Br , Sunarso Sunarso , Roessali Wiludjeng 
Published: August 2020

Agrowisata memiliki tujuan yaitu untuk memberikan ilmu pengetahuan, edukasi, pengalaman rekreasi dan mengenal hubungan usaha dibidang pertanian. Kebun Buah Cepoko merupakan salah satu Kebun Satuan Kerja milik UPTD. Kebun Dinas Pertanian yang sangat potensial untuk dijadikan Agrowisata. Penelitian ini bertujuan untuk menganalisis kepuasan pengunjung terhadap perkembangan Agrowisata Kebun Buah Cepoko, menganalisis Faktor Internal dan Eksternal yang mempengaruhi pengembangan Agrowisata Kebun Buah Cepoko dan menetapkan strategi dalam pengembangan Agrowisata Kebun Buah Cepoko. Penelitian ini dilaksanakan di Unit Pelaksana Teknis Dinas (UPTD) Kebun Dinas, Kebun Buah Cepoko,Kecamatan Gunung Pati. Analisis data yang digunakan untuk menjawab tujuan yaitu Analisis CSI, Analisis Matriks Evaluasi Faktor Internal dan Eksternal danAnalisis SWOT. Hasil penelitian menunjukkan indeks kepuasan pengunjung Agrowisata Kebun Buah Cepoko, diketahui nilai CSI adalah 77,81 persen sehingga dapat dikatakan bahwa secara keseluruhan pengunjung Agrowisata Kebun Buah Cepoko puas terhadap atribut Kebun Buah Cepoko.Posisi Agrowisata Kebun Buah Cepoko berdasarkan kondisi internal dan eksternal berada pada kuadran I yang menunjukkan bahwa Agrowisata Kebun Buah Cepoko berada pada situasi yang sangat menguntungkan karena memiliki kekuatan dan peluang yang dapat dimanfaatkan sebaik-baiknya dengan cara menerapkan strategi pertumbuhan agresif.
APA YANG MENDORONG DIVERSIFIKASI PENDAPATAN PETANI?: TINJAUAN EMPIRIS RUMAH TANGGA TANI PADI PROVINSI JAWA TIMUR
Authors: Wirakusuma Gilang 
Published: August 2020

Diversifikasi pendapatan merupakan salah satu strategi rumah tangga tani untuk memaksimalkan penggunaan sumber daya yang didasari berbagai motif. Penelitian ini dilakukan untuk mengukur tingkat diversifikasi pendapatan pada rumah tangga tani padi serta mengidentifikasi faktor penentu pada diversifikasi yang mereka lakukan. Dengan menggunakan data pada level rumah tangga, tingkat diversifikasi dianalisis dengan formula Indeks Keberagaman Simpson (IKS). Sementara itu, identifikasi faktor penentu diversifikasi pendapatan diuji dengan metode Censored Tobit Regression. Hasil analisis menunjukkan bahwa derajat diversifikasi pendapatan rumah tangga petani padi di Provinsi Jawa Timur umumnya rendah. Walaupun demikian, IKS tetap mengindikasikan bahwa rumah tangga petani padi memperoleh pendapatan mereka dari sumber mata pencaharian yang beragam. Lebih lanjut, tingkat diversifikasi pendapatan secara signifikan ditentukan oleh faktor-faktor yang berasal dari aspek karakteristik rumah tangga, usahatani, kepemilikan asset, institusi, dan ketersediaan pangan rumah tangga.
INSTITUTIONAL FARMERS' LAND TO INCREASE FARMER'S PRODUCTION, PRODUCTIVITY AND INCOME
Authors: Ekowati Titik , Prasetyo Edy , Eddy Bambang Trisetyo 
Published: August 2020

Farm land management institutional in term of consolidation and corporate farming programs are the management of farm land especially wet rice field to fulfill the optimum farm scale that manage by farmer’s group and to get the value for farmers. Research was aimed to develop the farmer’s institutional by land consolidation and corporate farming approach. Survey method was used for research. Dalangan Village, Tawangsari District and Dukuh Village, Mojolaban District were determined for research location by purposive method based on the farm institutional. Simple random sampling was used to get 40 respondents who joined the institutional program and 40 respondents who were not affiliated with land institutions. Data were analyzed by descriptively. The research was held by farmer’s empowerment and assistance at the farmers group to make use of innovation technology. Result of research showed that 28 ha wet rice field was integrated to the program of 4 farmer’s groups. The implementation of program answered the scarcity of land and labor and it can be easily to manage the production factors. The impact of the programs were increasing paddy production, prodoctivity, cost production effiecientcy by IDR 374.643,56/ha,/period increasing the usage of farm equipment, the created of the opportunity for employment, especially for women, to create the seedling and increasing the income of IDR 3.185.241.56/ha/period.