bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Robust Flexible Ferroelectric Field Effect Transistors Operable at High Temperature with Low‐Power Consumption
Authors: Ren Chuanlai , Zhong Gaokuo , Xiao Qun , Tan Congbing , Feng Ming , Zhong Xiangli , An Feng , Wang Jinbin , Zi Mengfei , Tang Mingkai , Tang Yong , Jia Tingting , Li Jiangyu 
Published: November 2019

AbstractFlexible ferroelectric field effect transistors (FeFETs) with multiple functionalities and tunable properties are attractive for low power sensing, nonvolatile data storage, as well as emerging memristor applications such as artificial synapses, though the state‐of‐art flexible FeFETs based on organic materials possess low polarization, large coercivity, and high operating voltage, and suffer from poor thermal stability. Here, developed is an all‐inorganic flexible FeFET based on epitaxial Pb(Zr0.1Ti0.9)O3/ZnO heterostructure on a mica substrate, which not only operates under a small voltage (±6 V) and thus consumes low power with an excellent on/off ratio of 104 as well as retention characteristics, but also shows robust FeFET performance under large bending deformation (4 mm), extended bending cycling (500 cycles), and high temperature operation at 200 °C. Importantly, the FeFET characteristics depend on temperature, but not on temperature history, critical for operation under repeated thermal loading. The excellent mechanical flexibility and functional robustness of the flexible FeFET originate from the unique van der Waals bonded layer structure of mica, facilitating a small bending radius yet modest strain. This work demonstrates the great promise of mica as a universal platform to integrate complicated functional devices for flexible electronics, especially under harsh environment.
Nanostructural Control Enables Optimized Photoacoustic–Fluorescence–Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor
Authors: Duan Yukun , Hu Dehong , Guo Bing , Shi Qi , Wu Min , Xu Shidang , Kenry  , Liu Xin , Jiang Jianwen , Sheng Zonghai , Zheng Hairong , Liu Bin 
Published: November 2019

AbstractThe performance of current multimodal imaging contrast agents is often constrained by the tunability of nanomaterial structural design. Herein, the influence of nanostructure on the overall imaging performance of a composite nanomaterial for multimodal imaging of brain tumors is studied. Newly designed near‐infrared molecules (TC1) are encapsulated into nanocomposites with ultrasmall iron oxide nanoparticles (UIONPs), forming stable nanoagents for multimodal imaging and photothermal therapy (PTT). Through a modified nanoprecipitation method, the synthesis of nanocomposites denoted as HALF is realized, in which UIONPs are restricted to half of the nanosphere. Such a unique nanostructure that physically separates TC1 and UIONPs is found with capabilities of mitigating fluorescence quenching, preserving the good performance of photoacoustic imaging, and enhancing the magnetic resonance imaging signals. Decorated with a peptide ligand cRGD for better brain tumor targeting, HALF‐cRGD is evaluated both in vitro and in vivo as imaging contrast agents and photothermal therapeutic agents. The good imaging performance and PTT effect of HALF‐cRGD in mice models indicate that the rational design and control of nanostructures could optimize multimodal imaging performance using the same components.
In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS‐Mediated Anticancer Therapy
Authors: Li Ling , Yang Zhen , Fan Wenpei , He Liangcan , Cui Cao , Zou Jianhua , Tang Wei , Jacobson Orit , Wang Zhantong , Niu Gang , Hu Shuo , Chen Xiaoyuan 
Published: November 2019

AbstractThe combination of reactive oxygen species (ROS)‐involved photodynamic therapy (PDT) and chemodynamic therapy (CDT) holds great promise for enhancing ROS‐mediated cancer treatment. Herein, an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor is reported to integrate the synergistic effect of PDT/CDT for enhancing ROS‐mediated pancreatic ductal adenocarcinoma treatment. 2‐(1‐hexyloxyethyl)‐2‐devinylpyropheophorbide‐a photosensitizer is hybridized within the framework of HMON via an “in situ framework growth” approach. Then, the hollow cavity of HMONs is exploited as a nanoreactor for “in situ polymerization” to synthesize the polymer containing thiol groups, thereby enabling the immobilization of ultrasmall gold nanoparticles, which behave like glucose oxidase‐like nanozyme, converting glucose into H2O2 to provide self‐supplied H2O2 for CDT. Meanwhile, Cu2+‐tannic acid complexes are further deposited on the surface of HMONs (HMON‐Au@Cu‐TA) to initiate Fenton‐like reaction to covert the self‐supplied H2O2 into •OH, a highly toxic ROS. Finally, collagenase (Col), which can degrade the collagen I fiber in the extracellular matrix, is loaded into HMON‐Au@Cu‐TA to enhance the penetration of HMONs and O2 infiltration for enhanced PDT. This study provides a good paradigm for enhancing ROS‐mediated antitumor efficacy. Meanwhile, this research offers a new method to broaden the application of silica based nanotheranostics.
Designing Optimal Perovskite Structure for High Ionic Conduction
Authors: Gao Ran , Jain Abhinav C. P. , Pandya Shishir , Dong Yongqi , Yuan Yakun , Zhou Hua , Dedon Liv R. , Thoréton Vincent , Saremi Sahar , Xu Ruijuan , Luo Aileen , Chen Ting , Gopalan Venkatraman , Ertekin Elif , Kilner John , Ishihara Tatsumi , Perry Nicola H. , Trinkle Dallas R. , Martin Lane W. 
Published: November 2019

AbstractSolid‐oxide fuel/electrolyzer cells are limited by a dearth of electrolyte materials with low ohmic loss and an incomplete understanding of the structure–property relationships that would enable the rational design of better materials. Here, using epitaxial thin‐film growth, synchrotron radiation, impedance spectroscopy, and density‐functional theory, the impact of structural parameters (i.e., unit‐cell volume and octahedral rotations) on ionic conductivity is delineated in La0.9Sr0.1Ga0.95Mg0.05O3–δ. As compared to the zero‐strain state, compressive strain reduces the unit‐cell volume while maintaining large octahedral rotations, resulting in a strong reduction of ionic conductivity, while tensile strain increases the unit‐cell volume while quenching octahedral rotations, resulting in a negligible effect on the ionic conductivity. Calculations reveal that larger unit‐cell volumes and octahedral rotations decrease migration barriers and create low‐energy migration pathways, respectively. The desired combination of large unit‐cell volume and octahedral rotations is normally contraindicated, but through the creation of superlattice structures both expanded unit‐cell volume and large octahedral rotations are experimentally realized, which result in an enhancement of the ionic conductivity. All told, the potential to tune ionic conductivity with structure alone by a factor of ≈2.5 at around 600 °C is observed, which sheds new light on the rational design of ion‐conducting perovskite electrolytes.
Terahertz Nonlinear Optics of Graphene: From Saturable Absorption to High‐Harmonics Generation
Authors: Hafez Hassan A. , Kovalev Sergey , Tielrooij Klaas‐Jan , Bonn Mischa , Gensch Michael , Turchinovich Dmitry 
Published: November 2019

AbstractGraphene has long been predicted to show exceptional nonlinear optical properties, especially in the technologically important terahertz (THz) frequency range. Recent experiments have shown that this atomically thin material indeed exhibits possibly the largest nonlinear coefficients of any material known to date, paving the way for practical graphene‐based applications in ultrafast (opto‐)electronics operating at THz rates. Here the advances in the booming field of nonlinear THz optics of graphene are reported, and the state‐of‐the‐art understanding of the nature of the nonlinear interaction of graphene with the THz fields based on the thermodynamic model of electron transport in graphene is described. A comparison between different mechanisms of nonlinear interaction of graphene with light fields in THz, infrared, and visible frequency ranges is also provided. Finally, the perspectives for the expected technological applications of graphene based on its extraordinary THz nonlinear properties are summarized. This report covers the evolution of the field of THz nonlinear optics of graphene from the very pioneering to the state‐of‐the‐art works. It also serves as a concise overview of the current understanding of THz nonlinear optics of graphene and as a compact reference for researchers entering the field, as well as for the technology developers.
Spirophenylacridine‐2,7‐(diphenylphosphineoxide)‐fluorene: A Bipolar Host for High‐Efficiency Single‐Layer Blue Phosphorescent Organic Light‐Emitting Diodes
Authors: Lucas Fabien , Ibraikulov Olzhas A. , Quinton Cassandre , Sicard Lambert , Heiser Thomas , Tondelier Denis , Geffroy Bernard , Leclerc Nicolas , Rault‐Berthelot Joëlle , Poriel Cyril 
Published: November 2019

AbstractHerein, a high‐efficiency host material for single‐layer phosphorescent organic light‐emitting diodes (SL‐PhOLEDs) is reported. This host material is synthesized via an efficient approach and is constructed on the association of an electron‐rich phenylacridine unit connected by a spiro carbon atom to an electron‐deficient 2,7‐bis(diphenylphosphineoxide)‐fluorene. In addition to a high ET value and adequate highest occupied molecular orbital/lowest unoccupied molecular orbital energy levels, the key point in this molecular design is the suitable balance between hole and electron mobilities, which leads to a high‐performance blue SL‐PhOLED with an external quantum efficiency of 17.6% (current efficiency = 37.8 cd A−1 and power efficiency = 37.1 lm W−1) and a low Von of 2.5 V. This performance shows that the molecular design of the present host fulfills the criteria required for high‐efficiency SL‐PhOLEDs. The present performance is one of the highest reported to date for blue SL‐PhOLEDs and more importantly shows the potential of such a molecular design to reach very high‐performance single‐layer devices.
Double Layer at the Pt(111)–Aqueous Electrolyte Interface: Potential of Zero Charge and Anomalous Gouy–Chapman Screening
Authors: Ojha Kasinath , Arulmozhi Nakkiran , Aranzales Diana , Koper Marc T. M. 
Published: November 2019

AbstractWe report, for the first time, the observation of a Gouy–Chapman capacitance minimum at the potential of zero charge of the Pt(111)‐aqueous perchlorate electrolyte interface. The potential of zero charge of 0.3 V vs. NHE agrees very well with earlier values obtained by different methods. The observation of the potential of zero charge of this interface requires a specific pH (pH 4) and anomalously low electrolyte concentrations (<10−3 m). By comparison to gold and mercury double‐layer data, we conclude that the diffuse double layer structure at the Pt(111)‐electrolyte interface deviates significantly from the Gouy–Chapman theory in the sense that the electrostatic screening is much better than predicted by purely electrostatic mean‐field Poisson–Boltzmann theory.
Techno‐economic analysis of novel power generation system based on coal partial gasification technology
Authors: Ye Chao , Wang Qinhui , Luo Zhongyang , Fang Mengxiang , Cen Kefa 
Published: November 2019

AbstractA novel power generation system based on coal partial gasification has been proposed of which the coal feed rate is 50kg/s. It is mainly composed of oxygen‐blown CFB gasifier, CFB char combustor, heat recovery boiler and power generation unit. Coal is partly gasified with oxygen and steam to produce syngas and the syngas is sent to GT for power generation. The residue char is combusted in char combustor for power generation. Supercritical power generation technology is adopted in ST power generation unit and the parameter of the main steam is 560°C, 22.4MPa. Techno‐economic analysis of Partial Gasification Combined Cycle (PGCC) system is conducted and compared with IGCC. Law of conservation of energy and production capacity index method are adopted for thermodynamic and economic analysis, respectively. Efficiency of power generation, internal rate of return, and payback period are obtained by detailed calculation. The simulation results show that the efficiency of power generation of APGCC and PPGCC system are 49.44% and 51.37%, respectively, which are higher than that of IGCC. The fixed capital investment of PGCC is much lower than that of IGCC. The internal rate of return and payback period of APGCC 13.38% and 7.24 years, respectively which are ~9% higher and 8 years shorter than that of IGCC, respectively. This article provides a detailed analysis of PGCC which indicates that the PGCC technology has a promising prospect.
Spherical nanoparticle effects on the lower critical solution temperature phase behavior of poly(ε‐caprolactone)/poly(styrene‐co‐acrylonitrile) blends: Separation of thermodynamic aspects from kinetics
Authors: Naziri Amir Ali , Ehsani Morteza , Khonakdar Hossein Ali , Hemmati Farkhondeh , Jafari Seyed Hassan 
Published: November 2019

ABSTRACTThe effects of spherical nanosilica particles on the lower critical solution temperature (LCST) phase diagram of poly(ε‐caprolactone) (PCL)/poly(styrene‐co‐acrylonitrile) (SAN) blends are investigated by using isochronal dynamic temperature sweep tests at different cooling rates. A stronger dependency of the rheologically determined phase‐transition points on the cooling rate is observed in the presence of nanoparticles, which results from the large contribution of entropic surface tension of chains in the Gibbs free energy of mixing and much slower rate of PCL/SAN phase dissolution. By alleviating the effects of kinetic factors, it is found that the drop in the LCST‐type phase boundary of PCL/SAN blends by adding nanofiller is more apparent than real. However, the closest LCST phase diagram to the real steady‐state thermodynamic diagram shows an unexpected shift to lower temperatures by adding nanosilica. The migration of nanosilica particles to the SAN domains especially at lower cooling rates in the dynamic measurements is the most likely explanation of these observations. The findings that prove the profound impact of kinetic factors in dynamic temperature measurements are reached in a hybrid system, wherein the SAN chains are preferentially absorbed on the surface of a nanofiller having very small primary particle size. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48679.
Expression of the matrix metalloproteinases 2 and 9 in the rat small intestine during intrauterine and postnatal life
Authors: dos Reis Camila Audrey , de Miranda Soares Maria Albertina , Gomes José Rosa 
Published: November 2019

AbstractThe expressions of matrix metalloproteinases 2 and 9 have been described during the development, as an example in heart and tooth but not in the small intestine yet. In this context, this study aimed to evaluate the expressions of MMP‐2 and MMP‐9 in the small intestine of Wistar rats during intrauterine (IU) and postnatal (PN) life. Expressions were determined on the 15th and 18th days of IU life and the 3rd, 10th, 17th, 25th, and 32nd days of PN life. Intestinal samples obtained from six animals were submitted to zymography, immunohistochemistry, and staining with Masson's trichrome. The results showed that MMP‐2 and MMP‐9 were not expressed during IU life; however, after birth, MMP‐9 was immunolocalized in the goblet and mast cells. In conclusion, our results showed that MMP‐2 and MMP‐9 were not expressed in absorptive epithelial cells during the IU period of the small intestine but after birth, MMP‐9 was expressed in the goblet cells, and mast cells present in the lamina propria.
Copper‐Catalyzed Electrophilic Cyclization of N‐Propargylamines with Sodium Sulfinate for the Synthesis of 3‐Sulfonated Quinolines
Authors: Li Ling , Zhang Xing‐Guo , Hu Bo‐Lun , Zhang Xiao‐Hong 
Published: November 2019

AbstractA convenient and effective protocol for the synthesis of 3‐sulfonated quinolines via copper‐catalyzed electrophilic cyclization of N‐propargylamines has been developed, in which cheap and stable sodium sulfinates were utilized as green sulfonylation reagents. This cascade transformation involves radical addition, cyclization and dehydrogenative aromatization processes in a one‐pot reaction under mild conditions.
Water Quality and Fire Protection Trade‐Offs in Water Distribution Networks
Authors: Gibson John , Karney Bryan , Guo Yiping 
Published: November 2019

Key TakeawaysHaving enough water available for fighting fires is a significant driver in the design of distribution systems.A study was conducted to determine how North American fire protection practices affect water quality.With changes to fire protection practices, water distribution systems might have higher flow velocity, lower capital costs, and fewer water quality issues.
Experimentelle Ermittlung von Reibungsbeiwerten bei Steinstützkörpern aus Naturstein
Authors: Voit Klaus , Neyer Andreas , Schwenn Michael , Zeman Oliver 
Published: November 2019

AbstractBöschungs‐, Ufer‐ und Sohlsicherungen aus Naturstein erfreuen sich als naturnahe konstruktive Maßnahmen zunehmender Beliebtheit. Hinsichtlich ihrer Wirkungsweise können Steinkonstruktionen unterschieden werden in (1) solche mit stützender Wirkung, welche durch Schlichten oder Setzen errichtet werden, und in (2) Steinkörper und Berollungen, deren Herstellung durch Schütten oder Werfen erfolgt und die rein durch ein Beschweren der Böschung wirken. Bei Steinstützkörpern handelt es sich generell um vergleichsweise flexible Konstruktionen, die Verformungen im Dezimeterbereich aufnehmen können. Dabei erfolgt die Kraftübertragung im unvermörtelten Zustand von Stein zu Stein bzw. bei Versetzen der Steine im Mörtelbett über die Mörtelfuge. Durch die Reibung bzw. Reibungskraft zwischen den Steinen bzw. Mörtel und Stein können Schubkräfte übertragen bzw. aufgenommen werden, die bspw. einem auftretenden Erddruck entgegenwirken.Für Steinstützkörper gibt es bislang einige bestehende Ansätze für deren Bemessung, es wird jedoch nicht spezifisch auf den Nachweis der inneren Standsicherheit (Gleiten und Kippen in der Lagerfuge, mechanisches Steinversagen) eingegangen. Bei gegenständlichem Forschungsvorhaben wird versucht, Kennwerte für die Bemessung von Steinstützkörpern experimentell zu erfassen, um in einem nächsten Schritt Rückschlüsse auf die innere Standsicherheit von Steinstützkörpern ziehen zu können.
Combined effects of maternal exposure to fungicides on behavioral development in F1‐generation mice: 1. Several dose study of both imazalil and thiabendazole
Authors: Tanaka Toyohito , Suzuki Toshinari , Inomata Akiko , Moriyasu Takako 
Published: November 2019

AbstractBackgroundFew published studies are reported for neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to evaluate reproductive and neurobehavioral effects of maternal exposure to combined fungicides in mice.MethodsImazalil (IMZ) and thiabendazole (TBZ) were given in the diet to provide levels of 0/0% (control), 0.0015/0.006% (IMZ/TBZ), 0.006/0.018%, and 0.024/0.054% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F1 generation.ResultsNo adverse effect of IMZ/TBZ was observed in litter size, litter weight, or sex ratio at birth. The average body weight of male and female offspring was increased significantly in treatment groups during the lactation period. With respect to behavioral developmental parameters, the swimming head angle on PND 7 of male offspring was significantly accelerated in the treatment groups. After weaning, the movement time of exploratory behavior shortened in a significant dose‐related manner in adult males of the F1 generation. In adult females, the rearing time of exploratory behavior lengthened in a significant dose‐related manner in the F1 generation. Spontaneous behavior examination indicated that longitudinal patterns of each of the total distance and number of rearing were different during the control and treatment groups in the F1‐generation females. Parallel width of the control and treatment groups was significantly different in the average time of movement and rearing in the F1‐generation females.ConclusionsThe high‐dose level of IMZ/TBZ in the present study produced several adverse effects in neurobehavioral parameters after weaning without concurrent chemical administration in mice.
Rapid development of clone‐specific, high‐performing perfusion media from established feed supplements
Authors: Mayrhofer Patrick , Reinhart David , Castan Andreas , Kunert Renate 
Published: November 2019

AbstractPerfusion cultivation of recombinant CHO cells is of substantial interest to the biopharmaceutical industry. This is due to increased space–time‐yields (STYs) and a short residence time of the recombinant protein in the bioreactor. Economic processes rely on cultivation media supporting rapid growth in the exponential phase and high protein production in the stationary phase at minimal media consumption rates. To develop clone‐specific, high‐performing perfusion media we present a straightforward and rapid two‐step approach combining commercially available basal media and feed supplements using design‐of‐experiment. First, the best performing feed supplements are selected in batch cultures. Then, the mixing ratio of selected feed supplements is optimized in small‐scale semicontinuous perfusion cultures. The final media formulation is supported by statistical response surface modeling of a set of cultivation experiments with blended media formulations. Two best performing novel media blends were finally applied to perfusion bioreactor verification runs to reach 200 × 106 c/ml within 2 weeks at minimum cell‐specific perfusion rates as low as 10–30 pL/c/d. Obtained STYs of 0.4–1.2 g/L/d represent a 10‐fold increase compared to batch cultures. This general workflow is universally applicable to any perfusion platform combining a specific cell line, basal medium, and established feed solutions.
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119
Authors: Cromm Philipp M. , Adihou Hélène , Kapoor Shobhna , Vazquez‐Chantada Mercedes , Davey Paul , Longmire David , Hennes Elisabeth , Hofer Walter , Küchler Philipp , Chiarparin Elisabetta , Waldmann Herbert , Grossmann Tom N. 
Published: November 2019

AbstractThe acyl‐binding UNC119 proteins mediate the activation and transport of various N‐myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated, stabilized α‐helical peptides that target UNC119a. By using the hydrocarbon peptide‐stapling approach, cell‐permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells; this suggests UNC119a as a potential target for the inhibition of cytokinesis.
Delayed massive subcutaneous emphysema following Robicsek closure
Authors: Pavone Natalia , Cammertoni Federico , Bruno Piergiorgio , Chiariello Giovanni Alfonso , Graziano Giovanni , Massetti Massimo 
Published: November 2019

AbstractA surgical procedure may lead to unusual and unexpected clinical scenario. Good medical practice should always keep it in mind. So, a broken sternal steel wire was the rare cause of massive emphysema.