bluuebunny/crossref_metadata_2025_split huggingface dataset:
singlecellVR: interactive visualization of single-cell data in virtual reality
Authors: Stein David F. , Chen Huidong , Vinyard Michael E. , Qin Qian , Combs Rebecca D. , Zhang Qian , Pinello Luca 
Published: July 2020

AbstractSingle-cell assays have transformed our ability to model heterogeneity within cell populations. As these assays have advanced in their ability to measure various aspects of molecular processes in cells, computational methods to analyze and meaningfully visualize such data have required matched innovation. Independently, Virtual Reality (VR) has recently emerged as a powerful technology to dynamically explore complex data and shows promise for adaptation to challenges in single-cell data visualization. However, adopting VR for single-cell data visualization has thus far been hindered by expensive prerequisite hardware or advanced data preprocessing skills. To address current shortcomings, we presentsinglecellVR, a user-friendly web application for visualizing single-cell data, designed for cheap and easily available virtual reality hardware (e.g., Google Cardboard, ∼$10).singlecellVRcan visualize data from a variety of sequencing-based technologies including transcriptomic, epigenomic, and proteomic data as well as combinations thereof. Analysis modalities supported include approaches to clustering as well as trajectory inference and visualization of dynamical changes discovered through modelling RNA velocity. We provide a companion software package,scvrto streamline data conversion from the most widely-adopted single-cell analysis tools as well as a growing database of pre-analyzed datasets to which users can contribute.
Common variants contribute to intrinsic human brain functional networks
Authors: Zhao Bingxin , Li Tengfei , Smith Stephen M. , Xiong Di , Wang Xifeng , Yang Yue , Luo Tianyou , Zhu Ziliang , Shan Yue , Matoba Nana , Sun Quan , Yang Yuchen , Hauberg Mads E. , Bendl Jaroslav , Fullard John F. , Roussos Panagiotis , Lin Weili , Li Yun , Stein Jason L. , Zhu Hongtu 
Published: July 2020

AbstractThe human brain remains active in the absence of explicit tasks and forms networks of correlated activity. Resting-state functional magnetic resonance imaging (rsfMRI) measures brain activity at rest, which has been linked with both cognitive and clinical outcomes. The genetic variants influencing human brain function are largely unknown. Here we utilized rsfMRI from 44,190 individuals of multiple ancestries (37,339 in the UK Biobank) to discover and validate the common genetic variants influencing intrinsic brain activity. We identified hundreds of novel genetic loci associated with intrinsic functional signatures (P< 2.8 × 10−11), including associations to the central executive, default mode, and salience networks involved in the triple network model of psychopathology. A number of intrinsic brain activity associated loci colocalized with brain disorder GWAS (e.g., Alzheimer’s disease, Parkinson’s disease, schizophrenia) and cognition, such as 19q13.32, 17q21.31, and 2p16.1. Particularly, we detected a colocalization between one (rs429358) of the two variants in theAPOEε4 locus and function of the default mode, central executive, attention, and visual networks. Genetic correlation analysis demonstrated shared genetic influences between brain function and brain structure in the same regions. We also detected significant genetic correlations with 26 other complex traits, such as ADHD, major depressive disorder, schizophrenia, intelligence, education, sleep, subjective well-being, and neuroticism. Common variants associated with intrinsic brain activity were enriched within regulatory element in brain tissues.
Career success in academia
Authors: Sherif Karma , Nan Ning , Brice Jeff 
Published: July 2020

PurposeIn this study, the authors explore the boundaryless careers of faculty and adopt the intelligent career framework to examine success factors for academic careers.Design/methodology/approachThe authors conducted a field study of 36 researchers in the management information systems field from 22 institutions in the US, Australia and Canada. The authors selected the participants representing four strata of researchers: luminaries (high expertise status and high citizenship behavior), experts (high expertise status but low leadership roles), statesmen (low expertise status but high leadership) and journeymen (low expertise status and low leadership). Data regarding the participants' experience of social relationships and social resources as well as entrepreneurial motivations were collected and analyzed.FindingsResults show that faculty who “know-why”, “know-how”, and “know with whom” possess socially valued resources and are successful in advancing their careers. They establish high social status and exercise power within their networks to mobilize resources that promote their careers. On the other hand, faculty who fall short of these competencies impose social closure on themselves and do not strive to exploit resources available through their contacts. The study advances a number of theoretical propositions to guide future research on boundaryless intelligent careers.Social implicationsSocial relationships and social resources do not substitute individual competence, leadership and entrepreneurial motivations; individuals need to develop competence valued by their professional communities and exploit available opportunities and assume leadership roles in order to effectively establish instrumental relationships and mobilize social resources to achieve career advancement.Originality/valueIn this study, we attempt to extend career development research through an examination of the bidirectional relationship between know-why, know-how and know-who in academia.
Forecasting key indicators of China's inbound and outbound tourism: optimistic–pessimistic method
Authors: Javed Saad Ahmed , Ikram Muhammad , Tao Liangyan , Liu Sifeng 
Published: July 2020

PurposeTourism industry is a highly complex system surrounded by many uncertainties because of its innumerable connections with other supporting systems. Considering tourism, a grey system, the current study proposes optimistic–pessimistic method (OPM). This technique can aid in improving forecast accuracy of four tourism-related indicators, inbound tourism to China, outbound tourism from China, revenues collected through inbound tourism and expenses incurred on outbound tourism.Design/methodology/approachThe study integrates OPM into EGM and then using the secondary data collected from the World Bank database, predicts the four tourism-related indicators. The mean absolute percentage error steered the performance of the models.FindingsOne of the main contributions of the study lies in its overall evaluation of one of the major travel and tourism countries of the world in light of four crucial indicators. The study highlights, four tourism-related indicators' recent information, contains more valuable information about the future.Originality/valueOPM represents a novel application of concept of whitenization of interval grey number in grey forecasting theory.
Examining knowledge transfer activities in UK universities: advocating a PROMETHEE-based approach
Authors: Ishizaka Alessio , Pickernell David , Huang Shuangfa , Senyard Julienne Marie 
Published: July 2020

PurposeThe purpose of this study is to examine the portfolio of knowledge transfer (KT) activities in 162 UK higher education institutions. In doing so, this study creates an index and ranking, but more importantly, it identifies specific groupings or strategic profiles of universities defined by different combinations and strengths of the individual KT activities from which the overall rankings are derived. Previous research, concentrating on entrepreneurial universities, shows that individual knowledge transfer (KT) activities vary substantially among UK universities. The broad portfolio of universities' KT activities, however, remains underexplored, creating gaps in terms of the relative strength, range, focus and combination of these activities, and the degree to which there are distinct university strategic KT profiles. By examining KT activities and grouping universities into KT “types”, this research allows universities and policymakers to better develop and measure clearer KT-strategies.Design/methodology/approachThe present study applied the Preference Ranking Organization Method for the Enrichment of Evaluations (PROMETHEE) to rank universities based on their portfolio of KT activities. It utilised data from the 2015–2016 Higher Education Business and Community Interaction Survey dataset.FindingsFindings show that universities differ substantially in their portfolios of KT activities. By using PROMETHEE, a new ranking of universities is generated, based on their KT portfolio. This paper also identifies four distinct types or groups of universities based on the diversity and intensity of their KT activities: Ambidextrous, broad, focused and indifferent.Originality/valueThe study contributes to the entrepreneurship literature, and more specifically entrepreneurial activities of universities through new knowledge generated concerning university KT activity. The research extends the existing literature on university archetypes (including those concerned with the Entrepreneurial University) and rankings using a new technique that allows for more detailed analysis of the range of university KT activities. By applying the PROMETHEE approach, results illustrate a more nuanced definition of university KT activities than before, by simultaneously evaluating their overall strength, range, focus and combination, allowing us to identify the universities' strategic profiles based on their KT portfolios. Implications of the findings for key stakeholders include a potential need for government higher education policymakers to take into account the different mixes of university archetypes in a region when considering how best to support higher education and its role in direct and indirect entrepreneurship promotion through regional policy goals.
Passion, performance and concordance in rock “n” roll entrepreneurship
Authors: Schulte-Holthaus Stefan , Kuckertz Andreas 
Published: July 2020

PurposeNon-entrepreneurial passions may be the beginning of an extensive entrepreneurial journey. However, current passion theories cannot fully capture the essence of such passions and their effects. The purpose of this study is to explore and explain the real-life composition of passion and performance.Design/methodology/approachThe investigation was conducted with comparative causal mapping (CCM) on a qualitative sample of people we designate rock “n” roll entrepreneurs (i.e. individuals driven by a passion for music and who are successful both artistically and economically). Aggregated causal maps of passion elicited through semi-structured interviews were analyzed and contrasted with performance indicators.FindingsPassion is revealed to be an individual phenomenon, one composed of central and peripheral concepts that include—contrary to prior theories—personality traits and life contexts. Furthermore, the results suggest that the concordance of concepts determines the scope, degree and performance of passion.Research limitations/implicationsThis study complements prevailing passion theories in psychology and entrepreneurship. As a context-bound study, the generalizability of the results is limited to its context, which, however, paves a clear way for future research.Practical implicationsCreative economy entrepreneurs and educators can use the mechanism of concordance to consciously reflect passion-driven tensions between artistic, social and entrepreneurial demands and to translate passion into behavioral effectiveness.Originality/valueThis study is the first to use a CCM approach to investigate passion. Findings highlight the potential to research entrepreneurial phenomena at the intersection of emotion, cognition and action.
Impact of educational and gender inequality on income and income inequality in South Asian countries
Authors: Munir Kashif , Kanwal Ayesha 
Published: July 2020

PurposeThe objectives of this study are threefold: firstly, to measure the impact of educational inequality on income inequality, and per capita income; secondly, to measure the impact of gender inequality in education on income inequality, per capita income and educational inequality; and lastly, to test the Kuznets inverted U-shape hypothesis between inequality in education and average year of schooling.Design/methodology/approachThe study has adopted the Marin and Psacharopoulos (1976) model of human capital in which income earned by an individual can be estimated as a function of number of year spent in schooling or education. Gini coefficient is used as a measure of income inequality, while inequality in education is measured by Gini index of educational inequality. Gender inequality in education is measured by the difference between male and female enrolment ratios as a proportion of male enrolment. The study utilizes the data of six South Asian countries, i.e. Bangladesh, India, Maldives, Nepal, Pakistan and Sri Lanka from 1980 to 2010 at five-year average and employs fixed effect model (FEM) and random effect model (REM) for estimation.FindingsResult suggests that educational inequality and average year of schooling have positive and significant impact on income inequality. Primary (basic) education and tertiary (higher) education reduce income inequality, while secondary education widens income inequality. Negative relationship exists between educational inequality and per capita income. Unequal distribution of education among boys and girls at primary level increases income inequality, while reduces income inequality at tertiary level. Gender inequality in secondary and tertiary level of education reduces per capita income, while unequal distribution of education among boys and girls further increases the educational inequality. Kuznets inverted U-shape hypothesis does not hold between education expansion and educational inequality, while weak U-shape relationship exists in South Asian countries.Practical implicationsGovernment has to provide free education in poor regions and makes employment programs to reduce the income and educational inequality respectively, while to remove gender inequality in education it is necessary to build more schools especially for girls. Government has to launch different online education programs for expansion in education at all levels.Originality/valueThis study adds to the literature by analyzing whether the inequality in income increases (decreases) due to increase (decrease) in educational and gender inequality in South Asian countries. This study contributes in the existing literature by developing a measure of educational and gender inequality in education in South Asian countries.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/IJSE-04-2020-0226.
Fiscal management performance and local economic development: evidence from a large emerging economy
Authors: de Mendonça Helder Ferreira , Peçanha Matheus Souza 
Published: July 2020

PurposeThis paper provides empirical evidence regarding the effect of fiscal management performance on local economic development in an emerging economy.Design/methodology/approachThe authors performed a panel data analysis based on data from the 5,568 Brazilian municipalities from 2006 to 2015. To consider if the difference in the characteristics of the municipalities can affect the results, the authors used different samples: a total of municipalities, metropolitan, nonmetropolitan, urban and rural municipalities. Furthermore, to check the difference of the effect on economic development associated with good and bad fiscal management in the municipalities, the authors considered a sample of the 500 best and the 500 worst fiscal management performances.FindingsThe findings indicate that an improvement in fiscal management is an important strategy to stimulate local economic development. In particular, the relevance of fiscal management performance to stimulate economic development is more significant in metropolitan and urban municipalities.Originality/valueThis analysis is the first to use data that take into account all the Brazilian municipalities covering information of the 21st century. Moreover, different from the previous literature, which considered efficiency from the data envelopment analysis (DEA), the authors used a fiscal management index that allowed one to consider a time-varying fiscal performance of the Brazilian municipalities.
Can a case lead approach deliver the “craft and graft” of integration?
Authors: Bailey Di , Mutale Gabriella Jennifer 
Published: July 2020

PurposeThe aim of this study was to explore the experiences and outcomes for adults with complex needs over time, within and between two teams that delivered integrated care across different Councils' services. The teams' approach to integration included two key features: a “case lead” way of working and the team itself operating as a single point of access (SPA) for residents in given neighbourhoods with high deprivation.Design/methodology/approachThe study was designed as evaluation research located in the realist tradition. Two teams acted as a case study to provide an in-depth understanding of how the case lead approach and SPA delivered the craft and graft of integrated working in the teams. Mixed methods of data collection included residents' ratings of their quality of life on five domains in an outcome measure over a six-month period. Residents and staff working in the teams also participated in semi-structured interviews to explore their respective experiences and receiving and delivering integrated care. The costs of care delivery incurred by residents were calculated based on their demands on public services in the year leading up to the teams' intervention and the projected costs for one year following this.FindingsThe relationship between team context, case leads' inputs and residents' outcomes was mediated through the managerial style in the integrated teams which enabled case leads to be creative and do things differently with residents. Case leads worked holistically to prevent residents being in crisis as well as giving practical help such as sorting debts and finances and supporting access to volunteering or further education. Residents rated their quality of life as significantly improved over a six-month period and significant savings in costs as result of the teams' support were projected.Originality/valueThe study used a multi-evaluation realistic evaluation methodology to explore the relationship between team context, case leads' inputs and residents' outcomes in terms that integrated services across different District and County Council Departments.
How perceptions of firm environmental and social values influence frontline employee outcomes
Authors: Gabler Colin B. , Landers V. Myles , Rapp Adam 
Published: July 2020

PurposeMore than ever, consideration of the natural environment and social welfare are values that firms must signal to their stakeholders. One way to do this is by adopting an environmental orientation (EO) and pro-social organizational identity (PSOI). The purpose of this paper is to examine how frontline employees (FLEs) respond to these firm-level values through four outcomes.Design/methodology/approachPolynomial structural equation modeling with response surface analysis was implemented on FLEs survey data to uncover how different levels of EO and PSOI impact sales performance, word-of-mouth, turnover intent and job satisfaction.FindingsBoth firm-level values have a positive and direct effect on all four outcomes. However, each imposes a boundary condition as well. Specifically, salespeople perform better when their firm has a stronger EO, but they are happier in their work, less likely to quit and more likely to spread positive word-of-mouth when PSOI is stronger.Practical implicationsThe results suggest that perceptions of a firm-level EO or PSOI enhance employee-level outcomes. Signaling to employees that your firm cares about the natural environment and the greater social good positively influences employee outcomes, but optimization of each outcome depends on the strength of those values.Originality/valueThis research answers two specific research calls. First, it applies signaling theory to the workplace context, positioning FLEs as the receivers and feedback mechanisms of firm-level signals. Second, using too-much-of-a-good-thing logic, it uncovers boundary conditions imposed by social and environmental constructs on frontline outcomes.
Enabling vulnerable populations: insights from the experiences of functionally illiterate consumers
Authors: Jayasundara Sachithra Kumari , Siriwardana Sajith , Jayawickrama Withanage Dushan Chaminda 
Published: July 2020

Purpose
The social transformation of “disadvantaged segments of society” requires an in-depth understanding of their behavioural reactions in different social contexts. To this end, the present study focuses on individuals who become vulnerable owing to their functional illiteracy in an “English”-dominant marketplace. Thus, the purpose of this study is to understand the sources of stress as perceived by functionally illiterate individuals and the mechanisms adopted by them to manage such stress when making “high-involvement” product purchases. Insights gained from the study would be beneficial for developing efficacious support programs for vulnerable populations.

Design/methodology/approach
In-depth interviews were conducted with 25 bottom-of-the-pyramid individuals living in slums and housing schemes located in and around Colombo, the capital city of Sri Lanka.

Findings
Two sources of perceived stress and five coping strategies were derived from the thematic analysis of the data. Participants highlighted the sources of their perceived stress as possible loss of resources and possible loss of self-esteem. Further, the participants were found to adopt several mechanisms to cope with the state of their stress and vulnerability experienced within English-dominant shopping environments, namely, seeking help from salespeople, continuing to shop at the same store, shopping with companions, “convenience purchasing” and buying only well-known brands.

Originality/value
These insights into the vulnerability, stress and coping mechanisms as experienced by functionally illiterate consumers will allow for the design of efficacious interventions to empower vulnerable populations.
What are you actually measuring? A review of techniques that integrate the stress response on distinct time‐scales
Authors: Gormally Brenna M. G. , Romero L. Michael 
Published: July 2020

AbstractThe field of stress physiology has rapidly expanded, particularly in those fields interested in identifying chronic stress in wild animals. Despite this expansion, stress remains difficult to assess and understand, due in large part to the temporal complexities of common stress measurement techniques.While the stress response happens on a short time‐scale, chronic stress results over longer time‐scales. Therefore, the temporal dynamics of techniques used to assess ‘stress’ need to be fully understood in order to be applied correctly.In this review, we provide information on 37 physiological and behavioural metrics that are commonly used to measure stress, especially in wild free‐living vertebrates, with a particular focus on which time‐scale they integrate stress.We organize these metrics into seven broad categories based on which physiological system they are most closely associated with (glucocorticoids, sympathetic/parasympathetic nervous system, immune, metabolic, cellular/molecular, tissue development and behaviour).We conclude by summarizing which kind of biological questions and variation each technique is most suitable for.This review will enable researchers to understand the temporal dynamics of stress measurement techniques for better design of future studies.A freePlain Language Summarycan be found within the Supporting Information of this article.