bluuebunny/crossref_metadata_2025_split huggingface dataset:
The socially parasitic ant Polyergus mexicanus has host‐associated genetic population structure and related neighbouring colonies
Authors: Sapp Joseph R. , Yost Jenn , Lyon Bruce E. 
Published: May 2020

AbstractThe genetic structure of populations can be both a cause and a consequence of ecological interactions. For parasites, genetic structure may be a consequence of preferences for host species or of mating behaviour. Conversely, genetic structure can influence where conspecific interactions among parasites lay on a spectrum from cooperation to conflict. We used microsatellite loci to characterize the genetic structure of a population of the socially parasitic dulotic (aka “slave‐making”) ant (Polyergus mexicanus), which is known for its host‐specificity and conspecific aggression. First, we assessed whether the pattern of host species use by the parasite has influenced parasite population structure. We found that host species use was correlated with subpopulation structure, but this correlation was imperfect: some subpopulations used one host species nearly exclusively, while others used several. Second, we examined the viscosity of the parasite population by measuring the relatedness of pairs of neighbouring parasitic ant colonies at varying distances from each other. Although natural history observations of local dispersal by queens suggested the potential for viscosity, there was no strong correlation between relatedness and distance between colonies. However, 35% of colonies had a closely related neighbouring colony, indicating that kinship could potentially affect the nature of some interactions between colonies of this social parasite. Our findings confirm that ecological forces like host species selection can shape the genetic structure of parasite populations, and that such genetic structure has the potential to influence parasite‐parasite interactions in social parasites via inclusive fitness.
Interactive effects of elevated CO2, warming, reduced rainfall, and nitrogen on leaf gas exchange in five perennial grassland species
Authors: Pastore Melissa A. , Lee Tali D. , Hobbie Sarah E. , Reich Peter B. 
Published: May 2020

AbstractGlobal changes can interact to affect photosynthesis and thus ecosystem carbon capture, yet few multi‐factor field studies exist to examine such interactions. Here, we evaluate leaf gas exchange responses of five perennial grassland species from four functional groups to individual and interactive global changes in an open‐air experiment in Minnesota, USA, including elevated CO2 (eCO2), warming, reduced rainfall and increased soil nitrogen supply. All four factors influenced leaf net photosynthesis and/or stomatal conductance, but almost all effects were context‐dependent, i.e. they differed among species, varied with levels of other treatments and/or depended on environmental conditions. Firstly, the response of photosynthesis to eCO2 depended on species and nitrogen, became more positive as vapour pressure deficit increased and, for a C4 grass and a legume, was more positive under reduced rainfall. Secondly, reduced rainfall increased photosynthesis in three functionally distinct species, potentially via acclimation to low soil moisture. Thirdly, warming had positive, neutral or negative effects on photosynthesis depending on species and rainfall. Overall, our results show that interactions among global changes and environmental conditions may complicate predictions based on simple theoretical expectations of main effects, and that the factors and interactions influencing photosynthesis vary among herbaceous species.
Nurses’ required end‐of‐life care competence in health centres inpatient ward – a qualitative descriptive study
Authors: Haavisto Elina , Soikkeli‐Jalonen Anu , Tonteri Mia , Hupli Maija 
Published: May 2020

BackgroundStudies of nurses’ required competence in EOL care in health centres are rare. It is important to produce information about experienced nurses’ perceptions of the competence they consider important in their practical work.AimThe aim of this study was to describe nurses’ required competence in EOL care in health centre inpatient wards as experienced by nurses.MethodA descriptive qualitative study using four semi‐structured group interviews (20 nurses) and inductive descriptive content analysis.ResultsFive categories describing nurses’ required competence in EOL care in a health centre inpatient ward were identified: (1) ethics and courage in action, (2) support for the patient, (3) support for the family, (4) care planning and (5) physical care. Factors promoting nurses’ competence in EOL care comprised two categories: (1) professional development in EOL care and (2) an organisation that supports EOL care.ConclusionsEnd‐of‐life care in health centre inpatient wards requires wide and complex competence from nurses. Nurses’ experiences of required competence are associated with holistic care of the patient, encountering the family and multiprofessional cooperation. Nurses’ competence in EOL care could be enhanced with postgraduate education, and educational planning should be given more attention in the future.
Implementation of individual placement and support in a first‐episode psychosis unit: A new way of working
Authors: Hillborg Helene , Bergmark Magnus , Bejerholm Ulrika 
Published: May 2020

AbstractThe aim of this study is to explore the IPS implementation process in a first‐episode psychosis (FEP) mental health service team in Sweden. More specifically, the study explores how integration processes and critical situations are perceived over time by team members who originated from two diverse welfare organizations. A serial interview design was used (initially, at 6 and 12 months) to describe experiences of 16 team members. Material was analyzed using a constant comparison grounded theory approach. Team members dealt with the ambivalence of sharing mental health information, and whether the new way of working was a risk or benefit for users. They gradually learned new perspectives and knowledge, built trust and shared common views. After a year, the team workload perceived reduced and became person‐centred. Some members described remaining unclear roles and requested further support. Negotiated goals for integration and early knowledge transfer are critical. Organizational change and trusting team relationships have to be facilitated. Anticipated gains of integration should be clearly described and discussed early on, and continuous support for sustainability should be considered. This study confirmed the importance and potential of integrating IPS into FEP teams.
Ultrasonographic appearance of pseudo‐placentational endometrial hyperplasia in a dog
Authors: Ma Ling‐Ya , Heng Hock Gan , Chia Min‐Yuan , Cheng Feng‐Pang , Lin Cheng‐Chung , Chen Kuan‐Sheng 
Published: May 2020

AbstractA 5‐year‐old, clinically normal intact female Miniature Schnauzer was presented for demonstrative ultrasonography in a seminar. She had two pregnancies in the past and had a natural mating 2 months previously. Ultrasonography revealed a segmental and circumferential mural thickening of the right uterine horn. The endometrium was markedly thickened with multiple organized hyperechoic linear striations, perpendicular to the mucosal surface. Histology revealed focal endometrial hyperplasia resembling the maternal tissue of the normal canine placenta. A diagnosis of spontaneous pseudo‐placentational endometrial hyperplasia (PEH) was made. This study described a unique ultrasonographic appearance of PEH, which may facilitate the diagnosis of PEH.
Analysis of Radial Compressor Performance at Low Pressure Ratios and Compressor Choke
Authors: Schloßhauer Adrian , Falke Felix , Klütsch Johannes , Kreienborg Iris , Pischinger Stefan 
Published: May 2020

Abstract
Strong transient engine load steps can result in low pressure ratio (ΠC) compressor operation for single stage turbocharged (TC) systems. For conventional full load TC engine matching using one-dimensional (1D)-engine process simulation, these operating points are of limited relevance and are consequently less studied. However, for the layout of sequential turbocharging systems, low pressure ratio compressor operation has to be thoroughly understood. Therefore, in this paper, three-dimensional (3D)-computational fluid dynamics (CFD) simulations will be presented, which analyze the stationary compressor behavior at low pressure ratios. Operating points at ΠC&lt;1 are investigated by reducing the compressor outlet pressure. The simulation results are validated against measurement data acquired at a stationary hot gas test bench. The compressor performance is quantified by a corrected compressor torque. Opposed to the well-known operation at ΠC&gt;1, the compressor generates power close to zero speed for ΠC&lt;1 (turbine operation). At higher mass flowrates and ΠC&lt;1, the compressor consumes power. Pressure build-up in the wheel is overcompensated by losses in the diffusor and the volute resulting in a net pressure drop across the stage. The 3D-CFD simulations also allow a speed-dependent evaluation of the choking cross section inside the compressor. At low circumferential speeds, compressor choke occurs in the volute or at the wheel outlet. At higher speeds, choking is observed at the wheel inlet. This behavior must be accounted for compressor map extrapolation methods for 1D-engine process simulations in order to correctly predict the choking mass flowrate.
Progress on sodium reduction in South Korea
Authors: Park Hye-Kyung , Lee Yoonna , Kang Baeg-Won , Kwon Kwang-il , Kim Jong-Wook , Kwon Oh-Sang , Cobb Laura K , Campbell Norman R C , Blakeman Drew E , Kim Cho-il 
Published: May 2020

IntroductionHigh dietary sodium is a leading contributor to hypertension, and hypertension is the leading underlying cause of death globally. There is a robust body of evidence supporting the health benefits of sodium reduction. Sodium intake in South Korea is high, with about half the population consuming>4000 mg/day, twice the recommended upper limit.MethodsIn 2012, South Korea implemented its National Plan to Reduce Sodium Intake, with a goal of reducing population sodium consumption by 20%, to 3900 mg/day, by 2020. The plan included five key components: (1) a consumer awareness campaign designed to change food consumption behaviours; (2) increased availability of low-sodium foods at schools and worksites; (3) increased availability of low-sodium meals in restaurants; (4) voluntary reformulation of processed foods to lower sodium content; and (5) development of low-sodium recipes for food prepared at home. Monitoring and evaluation included tracking sodium intake and sources of dietary sodium using the Korea National Health and Nutrition Examination Survey.ResultsBy 2014, South Korea had reduced dietary sodium consumption among adults by 23.7% compared to a survey conducted in 2010 prior to implementation of a nationwide salt reduction campaign that used this comprehensive, multipronged approach. The reductions in sodium intake were accompanied by reductions in population blood pressure and hypertension prevalence. Although causal associations between the sodium reduction programme and reduced sodium intake cannot be made, the declines occurred with the introduction of the programme.ConclusionMulticomponent interventions have great potential to reduce population sodium intake. Lessons learnt from South Korea could be applied to other countries and are likely very relevant to other Asian countries with similar food sources and consumption profiles.
Effects of an automated digital brief prevention intervention targeting adolescents and young adults with risky alcohol and other substance use: study protocol for a randomised controlled trial
Authors: Kvillemo Pia , Strandberg Anna K , Gripenberg Johanna , Berman Anne H , Skoglund Charlotte , Elgán Tobias H 
Published: May 2020

IntroductionAdolescence and young adulthood is a period in life when individuals may be especially vulnerable to harmful substance use. Several critical developmental processes are occurring in the brain, and substance use poses both short-term and long-term risks with regard to mental health and social development. From a public health perspective, it is important to prevent or delay substance use to reduce individual risk and societal costs. Given the scarcity of effective interventions targeting substance use among adolescents and young adults, cost-effective and easily disseminated interventions are warranted. The current study will test the effectiveness of a fully automated digital brief intervention aimed at reducing alcohol and other substance use in adolescents and young adults aged 15 to 25 years.Methods and analysisA two-arm, double-blind, randomised controlled trial design is applied to assess the effectiveness of the intervention. Baseline assessment, as well as 3-month and 6-month follow-up, will be carried out. The aim is to include 800 participants with risky substance use based on the screening tool CRAFFT (Car,Relax, Alone, Forget, Friends, Trouble). Recruitment, informed consent, randomisation, intervention and follow-up will be implemented online. The primary outcome is reduction in alcohol use, measured by Alcohol Use Disorders Identification Test total score. Secondary outcomes concern binge drinking, frequency of alcohol consumption, amount of alcohol consumed a typical day when alcohol is consumed, average daily drinks per typical week, other substance use, mental health, sexual risk behaviours and perceived peer pressure. Moreover, the study involves analyses of potential moderators including perfectionism, openness to parents, help-seeking and background variables.Ethics and disseminationThe study was approved by the Swedish Ethical Review Authority (no. 2019–03249). The trial is expected to expand the knowledge on digital preventive interventions for substance using adolescents and young adults. Results will be disseminated in research journals, at conferences and via the media.Trial registration number24 September 2019, ISRCTN91048246; Pre-results.
Validation study: evaluation of the metrological quality of French hospital data for perinatal algorithms
Authors: Goueslard Karine , Cottenet Jonathan , Benzenine Eric , Tubert‐Bitter Pascale , Quantin Catherine 
Published: May 2020

ObjectiveThe aim of our validation study was to assess the metrological quality of hospital data for perinatal algorithms on a national level.DesignValidation study.SettingThis was a multicentre study of the French medicoadministrative database on perinatal indicators.ParticipantsIn each hospital, we selected 150 discharge abstracts for delivery (after 22 weeks of gestation), in 2014, and their corresponding medical records. Overall, 22 hospitals were included.InterventionsA single investigator performed blind data collection from medical records in order to compare data from discharge abstracts with data from medical records. Finally, 3246 discharge abstracts were studied.Primary and secondary outcome measuresSeventy items, including maternal and delivery characteristics and maternal morbidity, were collected for each delivery stay.ResultsThe concordance rate of maternal age at delivery was 94.8% (95% CI 93.8 to 95.4). Combining the two forms of pre-existing diabetes, the algorithm presented a PPV of 65.9% and a sensitivity of 75.7%. The concordance rate of gestational age at delivery was 91.8% (90.9 to 92.7). Regarding gestational diabetes, the PPV was 80.8% (79.4 to 82.2) and the sensitivity was 79.5% (78.1 to 80.9). Regardless of the algorithm explored, the PPV for vaginal delivery was over 99%. For the diagnosis codes corresponding to immediate postpartum haemorrhage, the PPV was 77.7% (76.3 to 79.1) and the sensitivity was 75.5% (74.0 to 77.0). The algorithm for stillbirth presented a PPV of 89.4% (88.3 to 90.5) and a sensitivity of 95.4% (94.7 to 96.1).ConclusionsThis first national validation study of many perinatal algorithms suggests that the French national hospital database is an appropriate data source for epidemiological studies, except for some indicators which presented low PPV and/or sensitivity.
Prevalence and associated factors of preterm birth in Ethiopia: systematic review and meta-analysis protocol
Authors: Muchie Kindie Fentahun , Lakew Ayenew Molla , Teshome Destaw Fetene , Yenit Melaku Kindie , Sisay Malede Mequanent , Mekonnen Fantahun Ayenew , Habitu Yohanes Ayanaw 
Published: May 2020

IntroductionPreterm birth (PTB) complications are the leading cause of death among neonates globally. The reduction in neonatal mortality is not remarkable in Ethiopia. Therefore, this review will assess the magnitude and associated factors of PTB in Ethiopia.Methods and analysisThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be followed during the systematic review. We will include all observational studies published from 1 January 2009 to 31 December 2019 that examined the level and/or associated factors of any type of PTB among live births in Ethiopia. Inclusion criteria will be all live births, PTB defined as delivery before 37 weeks gestation. The primary outcome will be PTB <37 weeks, and secondary outcomes including PTB <34, <32 and <28 weeks will be analysed. PubMed and Science Direct databases as well as Google search engine and Google Scholar will be searched. The pooled prevalence of preterm and effect size of association for associated factors will be analysed using the Stata software V.14. The heterogeneity between studies will be measured by I2 statistics. A random-effects model will be used to estimate if heterogeneity detected. Publication bias will be assessed using a funnel plot. Subgroup analysis will be sought based on possible characteristics of the studies, specific morbidity (like pre-eclampsia, hypertension), type of PTB (spontaneous or iotrogenic) and quality of study (high-quality or low-risk). Meta-regression will be considered for major covariates (maternal age and maternal body mass index) related to PTB. Forest plots will be used to present the combined estimate with 95% CIs. The quality of evidence of the outcomes will be assessed with the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach.Ethics and disseminationNo ethical approval is necessary for this systematic review. The findings will be published in a peer-reviewed journal.PROSPERO registration numberCRD42017077356.
HbA1c as a predictor for response of bevacizumab in diabetic macular oedema
Authors: Sharma Sadhana , Joshi Sagun Narayan , Karki Pratap 
Published: May 2020

ObjectiveTo study the influence of glycosylated haemoglobin (HbA1c) on response of bevacizumab in patients with diabetic macular oedema.Methods and AnalysisA total of 37 eyes of 37 patients with vision loss due to diabetic macular oedema treated with bevacizumab were included in this study. Participants received monthly intravitreal bevacizumab (0.05 mL/1.25 mg) for 3 months.ResultsThere were 17 patients with baseline HbA1c ≤7% (<53mmol/mol) and 20 patients with baseline HbA1c >7% (>53mmol/mol) treated with bevacizumab included in the study. The mean improvement in visual acuity at 3 months was 0.50 logMAR in HbA1c ≤7%(<53mmol/mol) group and 0.33 logMAR in HbA1c >7%(>53mmol/mol) group (95% CI,-0.05-0.38; p=0.13). The mean central macular thickness (CMT) reduction was −229.76 µm in patients with a baseline HbA1c ≤7% (<53 mmol/mol) and −145.20 µm in patients with HbA1c of >7% (>53mmol/mol) (95% CI,12.98-156.14; p=0.022).ConclusionOur study suggests that baseline glycaemic control can affect the treatment outcome of intravitreal bevacizumab in the management of diabetic macular oedema and the response was found to be better in patients with good glycaemic control (low HbA1c).
Uptake of minimally invasive surgery and stereotactic body radiation therapy for early stage non-small cell lung cancer in the USA: an ecological study of secular trends using the National Cancer Database
Authors: Blom Erik F , ten Haaf Kevin , Arenberg Douglas A , de Koning Harry J 
Published: May 2020

BackgroundWe aimed to assess the uptake of minimally invasive surgery (MIS) and stereotactic body radiation therapy (SBRT) among early stage (stage IA–IIB) non-small cell lung cancer (NSCLC) cases in the USA, and the rate of conversions from MIS to open surgery.Materials and methodsData were obtained from the US National Cancer Database, a nationwide facility-based cancer registry capturing up to 70% of incident cancer cases in the USA. We included cases diagnosed with early stage (clinical stages IA–IIB) NSCLC between 2010 and 2014. In an ecological analysis, we assessed changes in treatment by year of diagnosis. Among surgically treated cases, we assessed the uptake of MIS and whether conversion to open surgery took place. For cases that received thoracic radiotherapy, we assessed the uptake of SBRT.ResultsAmong 117 370 selected cases, radiotherapy use increased 3.4 percentage points between 2010 and 2014 (p<0.0001). Surgical treatments decreased 3.5 percentage points (p<0.0001). Rates of non-treatment remained stable (range: 10.0%–10.6% (p=0.4066)). Among surgically treated stage IA cases, uptake of MIS increased from 28.7% (95% CI 27.8% to 29.7%) in 2010 to 48.6% (95% CI 47.6% to 49.6%) in 2014 (p<0.0001), while conversions decreased from 17.0% (95% CI 15.6% to 18.6%) in 2010 to 9.1% (95% CI 8.3% to 10.0%) in 2014 (p<0.0001). MIS uptake among stages IB–IIB was lower and conversion rates were higher, but time trends were similar. Uptake of SBRT among stage IA receiving thoracic radiotherapy increased from 53.4% (95% CI 51.2% to 55.6%) in 2010 to 73.0% (95% CI 71.4% to 74.6%) in 2014 (p<0.0001). SBRT uptake among stage IB increased from 32.5% (95% CI 29.9% to 35.2%) in 2010 to 48.2% (95% CI 45.6% to 50.8%) in 2014 (p<0.0001).ConclusionBetween 2010 and 2014, uptake of MIS and SBRT among early stage NSCLC significantly increased, while the rate of conversions to open surgery significantly decreased. Continuing these trends may contribute to improving patient care, in particular with the expected increase in early stages due to the implementation of lung cancer screening.
Swallowing functional outcomes and nutritional status in head and neck cancer radiotherapy: longitudinal study
Authors: Wang Yujie , Zhang Lichuan , Jin Shuai , Li Hongmei , Gong Liqing , Wang Yanli , Jin Sanli , Cao Yiwei , Shih Yian , Lu Qian 
Published: May 2020

ObjectiveTo explore the relationships between swallowing functional outcomes and nutritional status in patients with head and neck cancer undergoing radiotherapy (RT).MethodsThis longitudinal study included 122 patients. Data were collected at three time points: baseline (T1), the third week of RT (T2) and the completion of RT (T3). The Common Terminology Criteria for Adverse Events was used to assess the symptom of dysphagia and other toxicities; the MD Anderson Dysphagia Inventory (MDADI) was used to assess the patient-perceived swallowing functional outcomes; the nutritional status was evaluated by the weight ratio and the Patient-Generated Subjective Global Assessment (PG-SGA). The generalised estimating equation (GEE) was used to measure the correlation of MDADI with the weight ratio or PG-SGA and also to analyse the influential factors of swallowing functional outcomes.ResultsThe participants’ acute dysphagia rates were 5.7% at T1, 69.7% at T2and 77.9% at T3. The swallowing functional outcomes worsen over RT (p<0.001) and were associated with weight ratio (β=0.032, p=0.008) and PG-SGA (β=−0.115, p<0.001). GEE models showed that patients with cancer of the pharynx region, advanced stage, chemoradiotherapy and high RT dose perceived worse swallowing functional outcomes. Oral mucositis, pharynx mucositis and salivary gland inflammation were positively correlated with swallowing functional outcomes, and the pharynx mucositis presented the highest absolute value of β.ConclusionThe swallowing functional outcomes were negatively correlated with nutritional status. Healthcare professionals should identify early on the population at higher risk and focus on multiple toxicities, especially the management of pharynx mucositis, to improve nutritional status.