bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Angiotensin Receptor Blockers (ARBs) on In-Hospital Outcomes of Patients With Hypertension and Confirmed or Clinically Suspected COVID-19
Authors: Soleimani Abbas , Kazemian Sina , Karbalai Saleh Shahrokh , Aminorroaya Arya , Shajari Zahra , Hadadi Azar , Talebpour Mohammad , Sadeghian Hakimeh , Payandemehr Pooya , Sotoodehnia Mehran , Bahreini Maryam , Najmeddin Farhad , Heidarzadeh Ali , Zivari Ensieh , Ashraf Haleh 
Published: September 2020

AbstractBACKGROUNDThere is an ongoing controversy about harms and benefits of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in hypertensive patients with coronavirus disease 2019 (COVID-19). Given the unresolved debate, we investigated the association of ARBs with in-hospital outcomes of these patients.METHODSIn this retrospective observational study, we studied patients with COVID-19 who referred to Sina Hospital in Tehran, Iran, from 20 February to 29 May 2020. Patients with either positive real-time reverse-transcriptase polymerase-chain-reaction test of swab specimens, or high clinical suspicion according to the World Health Organization’s interim guidance were included. We followed-up patients for incurring death, severe COVID-19, and in-hospital complications.RESULTSWe evaluated 681 patients with COVID-19 of whom 37 patients were excluded due to incomplete medical records and 8 patients who used ACEIs which left 636 patients in the analysis. In this cohort, 108 (17.0%) patients expired and 407 (64.0%) patients incurred severe COVID-19. Of 254 (39.9%) patients with hypertension, 122 (48.0%) patients were receiving an ARB. After adjustment for possible confounders, we found no independent association between taking ARBs and in-hospital outcomes except for acute kidney injury (AKI), in patients with confirmed or clinically suspected COVID-19, either hypertensive or not-hypertensive. We found that discontinuation of ARBs during hospitalization was associated with a greater risk of mortality, invasive ventilation, and AKI (all P ˂ 0.002).CONCLUSIONSWe found that taking ARBs by patients with hypertension and confirmed or clinically suspected COVID-19 is not associated with poorer in-hospital outcomes after adjustment for possible confounders.
Haemosporidian parasites of Neotropical birds: Causes and consequences of infection
Authors: Ellis Vincenzo A , Fecchio Alan , Ricklefs Robert E 
Published: September 2020

AbstractHaemosporidian parasites of the genera Plasmodium, Haemoproteus, and Leucocytozoon are among the best studied parasites of Neotropical birds. Here, we describe variation in haemosporidian prevalence (i.e. the proportion of infected individuals in a sampled population) in Neotropical birds. We review correlates of haemosporidian prevalence (including several avian life-history traits, climate, and season) and the population and evolutionary consequences of infection for Neotropical birds. We find that prevalence varies among avian taxonomic families, genera, and even among species within the same genus, suggesting that prevalence reflects multiple factors, some of which (e.g., avian incubation period) are associated with avian family-level variation in prevalence while others (e.g., avian abundance) are associated with variation in prevalence among closely related host species. We find few correlates of prevalence that have been consistently demonstrated across studies. Prevalence in populations of many Neotropical birds has been estimated by microscopic examination of blood smears, which affords limited opportunity for comparison with data generated by molecular methods. However, at one site in the Brazilian Cerrado for which we have data, prevalence determined by microscopy does not correlate with prevalence determined by molecular methods for Plasmodium, but the 2 data types are positively correlated for Haemoproteus. Haemosporidians have been hypothesized to play a role in avian sexual selection, and we find the prevalence of Haemoproteus to be lower in polygynous species than in socially monogamous species in the Neotropics, confirming a pattern shown previously among Nearctic birds.
Drug–drug interaction prediction with Wasserstein Adversarial Autoencoder-based knowledge graph embeddings
Authors: Dai Yuanfei , Guo Chenhao , Guo Wenzhong , Eickhoff Carsten 
Published: September 2020

AbstractAn interaction between pharmacological agents can trigger unexpected adverse events. Capturing richer and more comprehensive information about drug–drug interactions (DDIs) is one of the key tasks in public health and drug development. Recently, several knowledge graph (KG) embedding approaches have received increasing attention in the DDI domain due to their capability of projecting drugs and interactions into a low-dimensional feature space for predicting links and classifying triplets. However, existing methods only apply a uniformly random mode to construct negative samples. As a consequence, these samples are often too simplistic to train an effective model. In this paper, we propose a new KG embedding framework by introducing adversarial autoencoders (AAEs) based on Wasserstein distances and Gumbel-Softmax relaxation for DDI tasks. In our framework, the autoencoder is employed to generate high-quality negative samples and the hidden vector of the autoencoder is regarded as a plausible drug candidate. Afterwards, the discriminator learns the embeddings of drugs and interactions based on both positive and negative triplets. Meanwhile, in order to solve vanishing gradient problems on the discrete representation—an inherent flaw in traditional generative models—we utilize the Gumbel-Softmax relaxation and the Wasserstein distance to train the embedding model steadily. We empirically evaluate our method on two tasks: link prediction and DDI classification. The experimental results show that our framework can attain significant improvements and noticeably outperform competitive baselines. Supplementary information: Supplementary data and code are available at https://github.com/dyf0631/AAE_FOR_KG.
Maternal high fat diet-induced obesity affects trophoblast differentiation and placental function in mice†
Authors: Kretschmer Tobias , Turnwald Eva-Maria , Janoschek Ruth , Zentis Peter , Bae-Gartz Inga , Beers Tim , Handwerk Marion , Wohlfarth Maria , Ghilav Mojgan , Bloch Wilhelm , Hucklenbruch-Rother Eva , Dötsch Jörg , Appel Sarah 
Published: September 2020

Abstract
Evidence suggests that maternal obesity (MO) can aggravate placental function causing severe pathologies during the perinatal window. However, molecular changes and mechanisms of placental dysfunction remain largely unknown. This work aimed to decipher structural and molecular alterations of the placental transfer zone associated with MO. To this end, mice were fed a high fat diet (HFD) to induce obesity before mating, and pregnant dams were sacrificed at E15.5 to receive placentas for molecular, histological, and ultrastructural analysis and to assess unidirectional materno-fetal transfer capacity. Laser-capture microdissection was used to collect specifically placental cells of the labyrinth zone for proteomics profiling. Using BeWo cells, fatty acid-mediated mechanisms of adherens junction stability, cell layer permeability, and lipid accumulation were deciphered. Proteomics profiling revealed downregulation of cell adhesion markers in the labyrinth zone of obese dams, and disturbed syncytial fusion and detachment of the basement membrane (BM) within this zone was observed, next to an increase in materno-fetal transfer in vivo across the placenta. We found that fetuses of obese dams develop a growth restriction and in those placentas, labyrinth zone volume-fraction was significantly reduced. Linoleic acid was shown to mediate beta-catenin level and increase cell layer permeability in vitro. Thus, MO causes fetal growth restriction, molecular and structural changes in the transfer zone leading to impaired trophoblast differentiation, BM disruption, and placental dysfunction despite increased materno-fetal transfer capacity. These adverse effects are probably mediated by fatty acids found in HFD demonstrating the need for obesity treatment to mitigate placental dysfunction and prevent offspring pathologies.
Dissecting Common and Unique Effects of Anti-α4β7 and Anti-Tumor Necrosis Factor Treatment in Ulcerative Colitis
Authors: Veny Marisol , Garrido-Trigo Alba , Corraliza Ana M , Masamunt Maria C , Bassolas-Molina Helena , Esteller Miriam , Arroyes Montserrat , Tristán Eva , Fernández-Clotet Agnès , Ordás Ingrid , Ricart Elena , Esteve Maria , Panés Julian , Salas Azucena 
Published: September 2020

AbstractBackground and AimsVedolizumab is an anti-α4β7 antibody approved for the treatment of ulcerative colitis [UC]. Although it is assumed that vedolizumab blocks intestinal homing of lymphocytes, its effects on different intestinal cell populations are not fully stablished. In order to establish the unique mechanisms of action of vedolizumab in UC patients, we compared its effects to those induced by anti-tumour necrosis factor [TNF].MethodsPatients with active UC [endoscopic Mayo score &gt;1] starting vedolizumab [n = 33] or anti-TNF [n = 45] and controls [n = 22] were included. Colon biopsies [at weeks 0, 14 and 46] and blood samples [at weeks 0, 2, 6, 14, 30 and 46] were used for cell phenotyping, transcriptional analysis [qPCR], and to measure receptor occupancy.ResultsVedolizumab, in contrast to anti-TNF, significantly reduced the proportion of α4β7+ cells within intestinal T subsets while preserving the percentage of α4β7+ plasma cells. The marked decrease in α4β7 did not change the percentage of colonic αEβ7+ cells [at 46 weeks]. Both vedolizumab and anti-TNF significantly downregulated inflammation-related genes in the colon of responders [Mayo score &lt; 2]. Moreover, both treatments significantly decreased the percentage of intestinal, but not blood, total lymphocytes [T and plasma cells], as well as the proportion of α4β1+ cells within intestinal T lymphocytes.ConclusionsOur data show that while vedolizumab and anti-TNF block two unrelated targets, they induce remarkably similar effects. On the other hand, vedolizumab’s unique mechanism of action relies on blocking intestinal trafficking of α4β7 T cells, despite effectively binding to B and plasma cells that express α4β7.
Week 6 Calprotectin Best Predicts Likelihood of Long-term Endoscopic Healing in Crohn’s Disease: A Post-hoc Analysis of the UNITI/IM-UNITI Trials
Authors: Narula Neeraj , Wong Emily C L , Dulai Parambir S , Marshall John K , Colombel Jean-Frederic , Reinisch Walter 
Published: September 2020

Abstract

Objectives
There is need for biomarkers as predictors of outcome of medical treatment in Crohn’s disease. The purpose of this study was to evaluate the predictive performance of faecal calprotectin for short- and long-term clinical and endoscopic outcomes.

Methods
This post-hoc analysis of the UNITI/IM-UNITI studies [NCT01369329, NCT01369342, and NCT01369355; YODA #2019–4026] included 677 patients to evaluate the relationship of Week 6 calprotectin cut-offs and changes from baseline assessments in calprotectin for prediction of outcomes at Weeks 8, 32, and 52, using receiver operating characteristic curves with comparisons of areas under the curve [AUC]. The relationship between clinical and biomarker assessments at Week 6 and endoscopic remission [ER] at Week 52 was evaluated using multivariate logistic regression models adjusted for confounders.

Results
A Week 6 calprotectin &lt;250 mg/kg demonstrated a significant ability to predict Week 52 ER (AUC 0.709, 95% confidence interval [CI] 0.566–0.852, p = 0.014) with fair accuracy, and performed better than other calprotectin cut-offs and deltas from baseline for prediction of Week 52 ER. When adjusted for covariates, patients with a Week 6 faecal calprotectin &lt;250 mg/kg had 3.48 times [95% CI 1.31–9.28, p = 0.013] increased odds of Week 52 ER. No other Week 6 clinical assessment [clinical remission or clinical response] or biomarker [CRP &lt;5 or drug level] had an association with Week 52 ER.

Conclusions
In summary, the results of this post-hoc analysis suggest that Week 6 calprotectin levels &lt; 250 mg/kg can be predictive of future endoscopic healing and may be more informative than clinical symptom improvement.

Podcast
This article has an associated podcast which can be accessed at https://academic.oup.com/ecco-jcc/pages/podcast
Enhancing EFL students’ participation through translanguaging
Authors: Kwihangana Felix 
Published: September 2020

Abstract
This study explored multilingual students’ attitudes towards translanguaging after the practice was introduced in group activities aimed at improving their English language skills and classroom engagement. A cohort of students taking a pre-sessional English course at a college of technology in Rwanda were initiated into translanguaging. They were then observed while translanguaging in group activities and interviewed later in focus groups to understand their acceptance of translanguaging as a resource for English language learning. Findings show that students engaged in translanguaging and acknowledged its benefits in their group activities. They nevertheless expressed reservations about embracing translanguaging as a formal pedagogy in their L2 classes. They were willing to opt for English-only classes regardless of their level of English language abilities. Students’ mixed feelings about translanguaging appeared to come from a perception of the English language as more relevant professionally and internationally than other local languages that constituted their multilingualism.
Prevalence, incidence, and outcomes across cardiovascular diseases in homeless individuals using national linked electronic health records
Authors: Nanjo Atsunori , Evans Hannah , Direk Kenan , Hayward Andrew C , Story Alistair , Banerjee Amitava 
Published: September 2020

Abstract

Aims
The risk and burden of cardiovascular disease (CVD) are higher in homeless than in housed individuals but population-based analyses are lacking. The aim of this study was to investigate prevalence, incidence and outcomes across a range of specific CVDs among homeless individuals.

Methods and results
Using linked UK primary care electronic health records (EHRs) and validated phenotypes, we identified homeless individuals aged ≥16 years between 1998 and 2019, and age- and sex-matched housed controls in a 1:5 ratio. For 12 CVDs (stable angina; unstable angina; myocardial infarction; sudden cardiac death or cardiac arrest; unheralded coronary death; heart failure; transient ischaemic attack; ischaemic stroke; subarachnoid haemorrhage; intracerebral haemorrhage; peripheral arterial disease; abdominal aortic aneurysm), we estimated prevalence, incidence, and 1-year mortality post-diagnosis, comparing homeless and housed groups. We identified 8492 homeless individuals (32 134 matched housed individuals). Comorbidities and risk factors were more prevalent in homeless people, e.g. smoking: 78.1% vs. 48.3% and atrial fibrillation: 9.9% vs. 8.6%, P &lt; 0.001. CVD prevalence (11.6% vs. 6.5%), incidence (14.7 vs. 8.1 per 1000 person-years), and 1-year mortality risk [adjusted hazard ratio 1.64, 95% confidence interval (CI) 1.29–2.08, P &lt; 0.001] were higher, and onset was earlier (difference 4.6, 95% CI 2.8–6.3 years, P &lt; 0.001), in homeless, compared with housed people. Homeless individuals had higher CVD incidence in all three arterial territories than housed people.

Conclusion
CVD in homeless individuals has high prevalence, incidence, and 1-year mortality risk post-diagnosis with earlier onset, and high burden of risk factors. Inclusion health and social care strategies should reflect this high preventable and treatable burden, which is increasingly important in the current COVID-19 context.
Development and preliminary validation of the competency model for rural general practitioner in China
Authors: Wei Yun , Liu Yanli , Zhao Xuexue , Jin Guanghui , Zhao Yali , Lu Xiaoqin 
Published: September 2020

Abstract

Background
There is a shortage of rural general practitioners (GPs) in China. Training programs have been initiated to meet the needs of GP workforce in the rural areas; however, there is an absence of validated tool to assess their competencies.

Objective
This study aimed to develop a competency model for rural general practitioner (CMRGP) after training in China and to examine its validity and reliability.

Methods
A multistage process was adopted to develop the CMRGP comprised literature review, panel discussion and expert consultation, and the initial version of CMRGP was reduced from 10 domains and 77 items to 7 domains and 54 items. A pilot study was conducted among 202 rural GPs for the psychometric evaluation and application of the initial version of CMRGP, in which a questionnaire on the importance of items and self-evaluation was completed by the GPs.

Results
In the pilot study, 132 completed questionnaires (65.3%) were returned. Acceptability and face validity of the CMRGP were supported by high importance scores of the items, in which 52 out of 54 items achieved score higher than 4.00 (possible score from 0 to 5). Factor analysis supported the construct validity. After the modification, the final version of CMRGP contained 6 domains and 47 items. Good reliability was supported by internal consistency reliability (Cronbach’s α was 0.98) and split-half reliability (Spearman–Brown coefficient was 0.99).

Conclusions
The CMRGP demonstrated good reliability and validity. Pilot study showed its potential for application in the rural general practice and training program.
Determinants of Fall Prevention Guideline Implementation in the Home- and Community-Based Service Setting
Authors: Juckett Lisa A , Bunger Alicia C , Jarrott Shannon E , Dabelko-Schoeny Holly I , Krok-Schoen Jessica , Poling Rachael M , Mion Lorraine C , Tucker Sharon 
Published: September 2020

Abstract

Background and Objectives
Home- and community-based service (HCBS) recipients often possess multiple fall risk factors, suggesting that the implementation of evidence-based fall prevention guidelines may be appropriate for the HCBS setting. The purpose of this exploratory study was to examine the determinants of fall prevention guideline implementation and the potential strategies that can support implementation in HCBS organizations.

Research Design and Methods
Semistructured interview and focus group data were collected from 26 HCBS professionals representing the home-delivered meals, personal care, and wellness programs. Qualitative codes were mapped to the Consolidated Framework for Implementation Research by means of directed content analysis. The Consolidated Criteria for Reporting Qualitative research checklist was used to report the findings of this study.

Results
We identified 7 major determinants of guideline implementation: recipient needs and resources, cosmopolitanism, external policy and incentives, networks and communication, compatibility, available resources, and knowledge/beliefs. Strategies to support guideline implementation included the involvement of recipient and caregiver feedback, building fall prevention networks, and conducting educational meetings for HCBS staff.

Discussion and Implications
Falls and fall-related injuries will continue to plague the older adult community unless innovative approaches to fall prevention are developed and adopted. The implementation of fall prevention guidelines in the HCBS setting can help mitigate fall risk among a highly vulnerable older adult population and may be facilitated through the application of multifaceted implementation strategies.
An exploration of constructs related to dissemination and implementation of an early childhood systems-level intervention
Authors: Farewell Charlotte V , Puma Jini , Bergling Emily , Webb Julie , Quinlan Jennie , Shah Puja , Maiurro Emily 
Published: September 2020

Abstract
Obesity and overweight in early childhood have detrimental impacts on children’s health and development. Changing policy, system and environmental features focused on physical activity and healthy eating behaviors as part of health promotion interventions can play a key role in prevention strategies in early childhood education settings. These types of changes can have broad reach and are often sustained over time, which allows for impact on children who enter the early childhood education setting year after year. However, there is currently a gap between the generation of evidence for health promotion programs and their application into practice. This study used qualitative methods to evaluate intervention-, organizational- and individual-level factors within a dissemination and implementation framework that may be related to the implementation of a health-promoting intervention in early childhood education settings. Intervention-level factors, including feasibility and adaptability, organizational-level factors, including staff and leadership engagement, and individual-level factors, including attitudes, skills and knowledge, were identified as constructs that impacted the successful implementation of the intervention. These findings provide insight into core dissemination and implementation constructs that should be targeted by obesity prevention interventions in early childhood education settings to ensure maximum impact on sustainable behavior change.
Early Life Disruption of the Microbiota Affects Organ Development and Cytokine Gene Expression in Threespine Stickleback
Authors: Kirschman Lucas J , Khadjinova Anastasia , Ireland Kelly , Milligan-Myhre Kathryn C 
Published: September 2020

SynopsisThe microbiota that inhabits vertebrates exerts strong effects on host physiology and can be crucial to the development of a normal phenotype. This includes development of the immune system, somatic growth and maintenance, and morphogenesis. However, the genetic background of the host can also affect these life history traits. To this end, we investigated the effects of the microbiota on growth, development, and immune gene expression on two populations of threespine stickleback (Gasterosteus aculeatus), one anadromous and one freshwater. We tested the hypotheses that microbial colonization and the genetic background of the host would affect survival, cytokine gene expression, growth, and development. We raised in vitro crosses of stickleback larvae with and without conventional microbiota. We then exposed all these treatments to Vibrio anguillarum, a potential fish pathogen, in a full factorial design. We found stickleback raised without conventional microbiota had smaller swim bladders relative to those raised with conventional microbiota. Stickleback raised with conventional microbiota exhibited small increases in cytokine gene expression. We found no differences in growth or survival regardless of treatment. These results are consistent with other investigations that show microbiota disruption, in early life, can alter host organ and tissue development and immune responses
Basic Cohomology of Canonical Holomorphic Foliations on Complex Moment-Angle Manifolds
Authors: Ishida Hiroaki , Krutowski Roman , Panov Taras 
Published: September 2020

Abstract
We describe the basic cohomology ring of the canonical holomorphic foliation on a moment-angle manifold, LVMB-manifold, or any complex manifold with a maximal holomorphic torus action. Namely, we show that the basic cohomology has a description similar to the cohomology ring of a complete simplicial toric variety due to Danilov and Jurkiewicz. This settles a question of Battaglia and Zaffran, who previously computed the basic Betti numbers for the canonical holomorphic foliation in the case of a shellable fan. Our proof uses an Eilenberg–Moore spectral sequence argument; the key ingredient is the formality of the Cartan model for the torus action on a moment-angle manifold. We develop the concept of transverse equivalence as an important tool for studying smooth and holomorphic foliated manifolds. For an arbitrary complex manifold with a maximal torus action, we show that it is transverse equivalent to a moment-angle manifold and therefore has the same basic cohomology.