bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocular biometry and power of intra ocular lens among cataract patients in rural Eastern Ethiopia
Authors: KASSA MANDEFRO SINTAYEHU , GESSESSE GIRUM W 
Published: January 2020

Abstract
Background : The main objective of the study was to report on the main parameters of ocular biometry and Intra ocular lens power of patients attending a cataract surgical program in Eastern Ethiopia. Methods : The study was a cross sectional study on 765 eyes which were legible for cataract surgery during a mass eye camp conducted from April 04 to April 10, 2018 at Bisidimo Hospital,Eastern Ethiopia.Ocular biometric parameters such as axial length (AL), anterior chamber depth (ACD), mean corneal curvature (MCC) were measured using automated keratorefractometer(Retinomax) and Sonomed A - Scan. Analysis of variance and multivariate analysis were done to determine association of ocular biometry components with socio demography of the study subjects. Results : A total of 765 eyes were enrolled in this study. The mean corneal curvature and the mean anterior chamber depth were found to be 7.61 mm and 2.88mm respectively. The mean axial length was estimated to be 22.98 mm. The mean refractive power of Intra ocular lenses was calculated to be 19.34D. The mean axial length in females was shorter than that of males by 0.24 and this was statistically significant ( P - value = 0.01). Under multiple linear regression model gender had a statistically significant impact on the axial length. The mean Anterior chamber depth in males was also larger than that of females by nearly 0.1 and this was statistically significant (P - value = 0.001). Under multiple linear regression model both age and gender had a statistically significant impact on the anterior chamber depth. There was no a statistically significant difference on the mean Intra ocular lens power required for male and female patients.Conclusion : This study is the first of its kind to provide a larger population based normative data on the most important parameters of ocular biometry in Ethiopia.The female sex was a strong predictor of small axial length and shallow anterior chamber. Increasing age had no effect on the axial length but was found to be a stronger predictor of shallow anterior chamber. Key words : Axial length, Anterior chamber depth, Corneal curvature, Intra ocular lens.
Knowledge, Attitude, and Practice (KAP) of Diabetes and Diabetic Retinopathy among Patients with Diabetes in Riyadh City.
Authors: Al-Yahya Abdulrahman Abdullah , Almizel Abdulrahman , Alsulaiman Alwaleed Mohammad , barri Abdulrahman Mohammed , aladel fadwa 
Published: January 2020

Abstract
Objective To identify the knowledge, attitude, practice (KAP) of diabetes and diabetic retinopathy among Saudi patients with diabetes in Riyadh Saudi Arabia.Methods A cross sectional study that was conducted in 50 randomly selected primary care centers and two university hospitals, involving diabetic patients that are 18 years and older during May 2018 and December 2018 in Riyadh, Saudi Arabia, using a validated KAP-45 questionnaire to assess the KAP levels of diabetes and diabetic retinopathy.Results A total of 313 participants were enrolled in the study. Most of them 168(59.8%) were males and 38(12.3%) were illiterate and 141(45.4%) had at least a bachelor's degree. Most of them had a family history of DM and long standing history of DM The average knowledge score for diabetes was good and was suboptimal for diabetic retinopathy. While the attitude scores for both diabetes and diabetic retinopathy were suboptimal. Meanwhile the average practice score for diabetes was good and was low for diabetic retinopathy.Conclusions Findings observed in our study stress on the importance of improving education and awareness as it’s the key for controlling the disease and reducing its complications.
Willingness-to-pay for spectacles studies: a scoping review of rationales and methodologies
Authors: Graham Christine , Chan Ving Fai 
Published: January 2020

Abstract
Background The global recognition of uncorrected refractive error as the main cause of vision impairment has increasingly demand for affordable, available and accessible refraction and spectacle dispensing services. Willingness to pay (WTP) for spectacles studies afford context-specific planning for integration of these services into eye care service delivery. The aim of this scoping review was to identify the rationales and the range of methods used when conducting WTP for spectacles studies. Methods We undertook this scoping review, using a search from EBSCO (host), Medline, PubMed, SCOPUS, Google Scholar and ProQuest databases. We also searched Google and eyecare organisation’s websites for grey literature. We analysed the articles using the scoping review methodological framework proposed by Arskey and Marley. Results The search identified 237 from and only 14 were eligible. 79% (n=11) were published articles and 21% (n=3) were grey literature. All studies were from developing countries. Most of the studies reported rationales with a few that were vague. The majority of the studies used survey-based techniques, where the limitation and strengths were reported. Conclusion The scoping review highlighted the knowledge gap in reporting the WTP for spectacles methodologies that need to be considered in reporting future research. Keywords: Willingness to pay, spectacles, eyeglasses
Clinical effect of conbercept on improving diabetic macular ischemia by OCT angiography
Authors: Zhu Ziyi , Liang Youling , Yan Bin , Meng Zhishang , Long Kejun , Zhang Yiwei , Luo Jing 
Published: January 2020

Abstract
Purpose Varying degrees of macular ischemia generally occur in diabetic retinopathy (DR). This study aims to evaluate the effect of conbercept with 3+ pro re nata (PRN) on macular perfusion status in patients with diabetic macular edema (DME) and quantitatively assess changes in foveal avascular zone (FAZ) areas and capillary density in macular regions by applying OCT angiography (OCTA). Methods Fifty patients were divided into ischemic (n=31) and non-ischemic (n=19) groups according to the presence of ischemia on OCTA at baseline. All patients received interval injection of 0.5mg of conbercept with 3+ PRN principle. The FAZ areas and macular vessel density measured using OCTA were evaluated at baseline, 3 months, and 6 months after treatment in both groups. Results At months 3 and 6, the FAZ area in the ischemic group changed from 0.510±0.171mm 2 to 0.441±0.158mm 2 then to 0.427±0.153mm 2 (p=0.003, p=0.296); in the non-ischemic group, it remained stable (p=0.269, p=0.926). The superficial vessel density changed from 41.1%±4.1% to 42.5%±4.7% then to 42.6%±4.6% (p=0.043, p=0.812), and the deep vessel density changed from 40.7%±4.4% to 42.3%±3.6% then to 42.3%±4.7% (p=0.072, p=0.961) in the ischemic group. In the non-ischemic group, the superficial vessel density changed from 44.8%±3.2% to 46.0%±3.5% then to 45.7%±3.3% (p=0.108, p=0.666), whereas the deep vessel density changed from 43.6%±3.6% to 43.8%±3.2% then to 43.5%±4.5% (p=0.882, p=0.736). Reperfusion in macular nonperfusion areas was observed. Conclusion Anti–vascular endothelial growth factor treatment may have a positive effect on macular perfusion status, improve macular ischemia, and promote reperfusion appearance in patients with DME. Furthermore, OCTA had advantages in quantifying and calculating blood flow index in the study of macular perfusion status.
Metallic nanoparticles and ions accelerate the uptake of extracellular antibiotic resistance genes through transformation
Authors: Guo Jianhua , Zhang Shuai , Lu Ji , Wang Yue , Verstraete Willy , Yuan Zhiguo 
Published: January 2020

Abstract
Background: Antibiotic resistance genes (ARGs), heavy metal ions and nanoparticles (NPs) are emerging and ubiquitous contaminants in the environment. However, little is known about whether heavy metal-based NPs or ions could facilitate the dissemination of ARGs through natural transformation. This study evaluated the contributions of heavy metal-based NPs (Ag NPs, CuO NPs and ZnO NPs) and their ion forms (Ag + , Cu 2+ and Zn 2+ ) to the transformation of extracellular ARGs in Acinetobacter baylyi ADP1. Results: We found that these commonly-used NPs and ions from environmentally relevant concentrations can significantly promote the natural transformation frequency of ARGs by a factor of 11.0-folds, which is comparable to the effects of antibiotics. The enhanced transformation by Ag NPs, CuO NPs, Ag + and Cu 2+ was primarily associated with reactive oxygen species (ROS) over-production and cell membrane damage, which was also evident from up-regulations of both transcription and translation of ROS and outer membrane-related genes. Additionally, transmission electron microscope imaging revealed the roughened cell membrane after Ag NPs, CuO NPs, Ag + and Cu 2+ exposure. ZnO NPs and Zn 2+ might increase the natural transformation rate by stimulating the stress response and ATP synthesis. All tested NPs and ions resulted in up-regulating the competence and SOS response-associated genes. Conclusions: Our results demonstrate that Ag, CuO and ZnO-based NPs/ions from environmental concentrations could promote the natural transformation of plasmid-encoded ARGs into naturally competent A. baylyi . Our findings provide insights into the contributions of heavy metals and NPs to the spread of antibiotic resistance.
Oral manifestations in premature infants. A systematic review
Authors: Couto Lara Vivero , Pozo Elena Planells del , Escobar José Ignacio Salmerón , López Jorge Molina , Ruiz-Extremera Ángela , Pozo Paloma Planells del 
Published: January 2020

Abstract
Background Preterm delivery, defined as delivery occurring before a gestational age of 37 weeks, represents 6-10% of all births in developed countries. Preterm infants are characterized by a short prenatal development period and are at an increased risk of systemic disorders as a result of their immaturity. Few studies have analyzed oral alterations among preterm infants. This systematic review examines the orofacial characteristics most commonly found among preterm infants versus infants born at term and evaluates their repercussions upon oral health and quality of life.Methods The search was limited to articles published in English or Spanish that compared orofacial characteristics of preterm infants versus infants born at term. Their methodological quality was assessed based on the guidelines of the Joanna Briggs Institute (JBI).Results Most of the studies found the prevalence of structural enamel defects of the primary dentition to be greater among preterm infants. Other disorders such as structural enamel defects of the permanent dentition, caries, malocclusions or alterations in dental composition, size and development also appeared to be more frequent among preterm infants, though the supporting evidence was weak.Conclusions Further studies are needed, analyzing the association between preterm delivery and certain orofacial disorders such as caries, malocclusions and dental anomalies.
Comparative study between Fenton and Intergrowth 21 charts in a sample of Lebanese premature babies
Authors: Samarani Marie , Restom Gianna , Mardini Joelle , Fares Georges Abi , Hallit Souheil , Khalife Marie-Claude Fadous 
Published: January 2020

Abstract
Background: Different charts are used to assess premature growth. The Fenton chart, based on prenatal growth, was used in in the intensive care unit of the Notre Dame des Secours University Hospital to assess premature newborns’ development. Intergrowth21 is a new multidisciplinary, multiethnic growth chart better adapted to premature growth. Our objective was to compare both charts Fenton and Intergrowth21 in order to implement Intergrowth in our unit.Methods: We analyzed 318 files of premature babies born who were admitted to the NICU from 2010 till 2017. Anthropometric data (weight, height and head circumference) converted to percentiles was filled on both charts from birth till 1 month of age.Results: The results of the linear regression taking the weight at birth as the dependent variable, showed that the Fenton scale (R2=0.391) would predict the weight at birth better than the Intergrowth 21 scale (R2=0.257). The same applies for the height at birth and cranial perimeter at birth when taken as dependent variables. When considering the weight and height at 2 weeks, the results showed that the Intergrowth 21 scale would predict those variables better than the Fenton scale, with higher R2 values higher in favor of the Intergrowth 21 scale for both weight (0.384 vs 0.311) and height (0.650 vs 0.585). At 4 weeks, the results showed that the Fenton scale would predict weight (R2=0.655 vs 0.631) and height (R2=0.710 vs 0.643) better than the Intergrowth 21 scale. The results obtained are adjusted over the newborns’ sociodemographic and clinical factors.Conclusion:The results of our study are controversial where the Fenton growth charts are superior to Intergrowth 21 before two weeks of age and at 4 weeks, whereas Intergrowth 21 charts showed higher percentiles for weight and height than Fenton charts at 2 two weeks of age. Further studies following a different design, such as a clinical trial or a prospective study, and conducted in multiple centers should be considered to enroll a more representative Lebanese sample of children and be able to extrapolate our results to the national level.
A behavioral economic intervention to increase psychiatrist adherence to tobacco treatment guidelines: a provider-randomized study protocol
Authors: Rogers Erin , Wysota Christina , Prochaska Judith J. , Tenner Craig , Dognin Joanna , Wang Binhuan , Sherman Scott E. 
Published: January 2020

Abstract
BackgroundPeople with a psychiatric diagnosis smoke at high rates, yet are rarely treated for tobacco use. Health care systems often use a ‘no treatment’ default for tobacco, such that providers must actively choose (opt-in) to treat their patients who express interest in quitting. Default bias theory suggests that opt-in systems may reinforce the status quo to not treat tobacco use in psychiatry. We aim to conduct a pilot study testing an opt-out system for implementing a 3A’s (ask, advise, assist) tobacco treatment model in outpatient psychiatry.MethodsWe will use a mixed-methods, cluster-randomized study design. We will implement a tobacco use clinical reminder for outpatient psychiatrists at the VA New York Harbor Healthcare System. Psychiatrists (N = 20) will be randomized 1:1 to one of two groups: (1) Opt-In Treatment Approach: Psychiatrists will receive a reminder that encourages them to offer cessation medications and referral to cessation counseling; or (2) Opt-Out Treatment Approach: Psychiatrists will receive a clinical reminder that includes a standing cessation medication order and a referral to cessation counseling that will automatically generate unless the provider cancels. Prior to implementation of the reminders, we will hold a 1-hour training on tobacco treatment for psychiatrists in both arms. We will use VA administrative data to calculate the study’s primary outcomes: 1) the percent of smokers prescribed a cessation medication and 2) the percent of smokers referred to counseling. During the intervention period, we will also conduct post-visit surveys with a cluster sample of 400 patients (20 per psychiatrist) to assess psychiatrist fidelity to the 3 A’s approach and patient perceptions of the opt-out system. At six months, we will survey the clustered patient sample again to evaluate the study’s secondary outcomes: 1) patient use of cessation treatment in the prior 6 months and 2) self-reported 7-day abstinence at 6 months. At the end of the intervention period, we will conduct semi-structured interviews with 12-14 psychiatrists asking about their perceptions of the opt-out approach. DiscussionThis study will produce important data on the potential of opt-out systems to overcome barriers in implementing tobacco use treatment in outpatient psychiatry.
Correlation between clinical risk factors and tracheal intubation difficulty in infants with Pierre-Robin syndrome: A systematic review
Authors: Liu Yanli , Wang Jiashuo , Zhong Shan 
Published: January 2020

Abstract
Background: Difficult tracheal intubation is a problem commonly encountered by anesthesiologists in the clinic. Methods: In this retrospective study, case-level clinical data and computed tomography images of 96 infants with Pierre-Robin syndrome were included in the analysis. First, computed tomography images were labeled by a clinically experienced physician. Then color space conversion, binarization, contour acquisition, and area calculation processing were performed on the annotated files. Finally, we calculated the correlation coefficient between the seven clinical factors and tracheal intubation difficulty, and the difference in each risk factor under tracheal intubation difficulty. Results: The absolute value of the correlation coefficient between throat area and tracheal intubation difficulty is 0.54, and the difference of throat area under tracheal intubation difficulty is significant. Body surface area, weight and gender also show significant difference under tracheal intubation difficulty. Conclusions: There is a significant correlation between throat area and tracheal intubation difficulty in infants with Pierre-Robin syndrome. Body surface area, weight and gender may have an impact on tracheal intubation difficulty in infants with Pierre-Robin syndrome.
Identification of ‘Haryejosaeng’ mandarin by multiplex SNP genotyping
Authors: Jin Seong-Beom , Kim Ho Bang , Park Suk Man , Kim Min Ju , Kang Seok-Beom , Yang Gyeong-Rok , Yun Su-Hyun 
Published: January 2020

Abstract
BackgroundMost of the satsuma mandarin (Citrus unshiu Marc.) cultivars grown on Jeju Island farms, Korea, are difficult to improve through hybridization because of polyembryony and male sterility. Therefore, their improvement has mostly been based on the selection of nucellar embryo and bud mutation. These cultivars are supplied to breeders and farms at the seedling stage, which renders their identification based only on morphological traits. In addition, because these seedlings originate from nucellar embryo and bud mutation selection, they are genetically very similar. Therefore, the present study was carried out to develop markers that can specifically and rapidly distinguish ‘Haryejosaeng,’ which is generally supplied to breeders, from other satsuma mandarin cultivars that are planted on farms.ResultsPolymerase chain reaction (PCR) was performed to distinguish ‘Haryejosaeng’ from other 8 cultivars (‘Haryejosaeng’- breeder’s stock, ‘Miyagawa wase,’ ‘Okitsu wase,’ ‘Yura wase,’ ‘Miyamoto wase,’ ‘Ueno wase,’ ‘Yonezawa wase,’ and ‘Nichinan 1 gou’) using 6 single nucleotide polymorphism (SNP) markers specific for ‘Haryejosaeng’ and one SNP primer pair, which was used as the negative control. Using a multiplex PCR, SNP markers P1 (HL-SNP-SCAF_2-23997586-F and HL-SNP-SCAF_2-23997586-R), P2 (HL-SNP-SCAF_2-36059523-F and HL-SNP-SCAF_2-36059523-R), and P5 (HL-SNP-SCAF_9-30793978-F and HL-SNP-SCAF_9-30793978-R) simultaneously yielded 165, 150, and 526 bp amplicons, respectively, for Haryejosaeng only. The SNP markers were further validated by high-resolution melting analysis. The multiplex PCR based on P1/P5 and P2/P5 was also used to identify ‘Haryejosaeng’ on a farm growing 17 different cultivars of satsuma mandarin.ConclusionsWe developed specific molecular markers for accurate identification of ‘Haryejosaeng,’ which can be performed by multiplex PCR to save time and cost associated with the supply of ‘Haryejosaeng’ to farms.
Continuous inflorescence removal changes parameters, lignin and saponin a content and alters the transcriptome of root of Bupleurum chinense DC
Authors: Wang Hui , Zhang Gaixia , Gao Zhihui , Sui Chun , Wei Jianhe 
Published: January 2020

Abstract
BackgroundBupleurum chinense DC. is an important traditional medicinal plant, and its root as the only medicinal part named Radix Bupleuri is used widely for the treatments of influenza, fever, inflammation, etc. in China, Japan and Korea. As a bulk herb, this herbal medicine occupies a comparatively big market share and is widely cultivated. However, because of the vigorous flowering and fruiting, the root growth is influenced seriously. ResultsWe assessed the effect of the continuous inflorescence removal (CIR) on improving the yield and quality of Radix Bupleuri. The results showed that the taproot length, root head diameter, and lateral root numbers were significantly elevated by CIR. We also found an average 1.71-fold increase in root biomass, and the lower lignin and higher saponin a content were detected in roots of CIR-treated plants. Based on a comparative transcriptome analysis, 172, 243, 1974 and 3024 differentially expressed genes (DEGs) were respectively identified in the CIR-treated roots. Gene Ontology and KEGG pathway functional annotation analysis of the DEGs showed that multiple genes were involved sugars metabolism pathway, lignin and terpenoids biosynthesis pathway, and the plant hormones signal transduction pathway. In addition, 295 genes encoding transcription factors (TFs), including members of the ERF, MYB-related, bHLH, NAC, MYB, AUX/IAA and bZIP families etc, were identified as CIR responsive. ConclusionThe CIR treatment could improve the yield, quality and market value of B. chinense DC. medicine, and the first transcriptome profile of CIR-treated roots of B. chinense DC. provides a series of clues of the molecular mechanisms of these phenotype changes induced by CIR.
Comparison of the clinical efficacy of Wiltse paraspinal approach and O-arm navigation for the treatment of thoracolumbar fractures
Authors: Lu Yingjie , Zhu Tianfeng , Shen Xu , Fang Yuepeng , Lu Dongdong , Zhou Liyu , Zhu Xuesong , Gan Minfeng 
Published: January 2020

Abstract
Background To evaluate the clinical efficacy of Wiltse paraspinal approach and percutaneous pedicle screw placement under O-arm navigation for the treatment of thoracolumbar fracture.Methods We enrolled a total of 54 patients with neurologically intact thoracolumbar fracture that received minimally invasive technology. Among these, 28 cases were treated with pedicle screw fixation through Wiltse paraspinal approach (WPSF), and another 26 cases were received percutaneous pedicle screws fixation under O-arm navigation (OPSF). The statistical methods were used to performing a detailed comparison of clinical outcomes, radiologic findings and complications between the two groups at pre-op, post-op and last follow-up.Results There were no significant differences between the two groups among intraoperative bleeding, length of incision, postoperative hospitalization times and accuracy rate of pedicle screw placement (p>0.05). Visual analog scale (VAS) scores, Oswestry disability in­dex (ODI) scores, local Cobb angle (LCA), vertebral wedge angle (VWA) and R value were obviously improved after surgery, though no clear discrepancy between the groups at each time point (p>0.05). However, the OPSF group had longer operation time and higher surgical expenditure than the WPSF group (p<0.05).Conclusions Both WPSF and OPSF were safe and effective for the treatment of thoracolumbar fracture. Although the two groups showed favorable clinical and radiologic outcomes till the final follow-up, we recommended the minimally invasive technology of WPSF considering the lower duration of surgery and medical costs. A randomized controlled study of high-quality and large sample required to prove our findings in the future.