bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing size–frequency distributions as a method of ontogenetic aging: a life-history assessment of hadrosaurid dinosaurs from the Dinosaur Park Formation of Alberta, Canada, with implications for hadrosaurid paleoecology
Authors: Wosik Mateusz , Chiba Kentaro , Therrien François , Evans David C. 
Published: September 2020

AbstractHadrosaurid dinosaurs, the dominant large-bodied terrestrial herbivores in most Laurasian Late Cretaceous ecosystems, have an exceptional fossil record consisting of many species known from partial ontogenetic series, making them an ideal clade with which to conduct life-history studies. Previous research considered the Dinosaur Park Formation (DPF) of Alberta as an attritional, or time-averaged, sample and interpreted size–frequency distribution of long bones collected from the DPF with three size classes to suggest that hadrosaurids from the DPF attained near-asymptotic body size in under 3 years. This conflicted with previously published osteohistological estimates of 6+ years for penecontemporaneous hadrosaurids from the Two Medicine Formation (TMF) of Montana, suggesting either extreme variation in hadrosaurid growth rates or that size–frequency distributions and/or osteohistology and growth modeling inaccurately estimate ontogenetic age.We tested the validity of the previously proposed size–age relationship of hadrosaurids from the DPF by significantly increasing sample size and combining data from size–frequency distributions and osteohistology across multiple long-bone elements. The newly constructed size–frequency distributions typically reveal four relatively distinct size–frequency peaks that, when integrated with the osteohistological data, aligned with growth marks. The yearling size class was heavily underrepresented in the size–frequency distribution. If not due to preservation, this suggests that either juvenile (<2 years of age) hadrosaurids from the DPF had increased survivorship following an initially high nestling mortality rate or that yearlings were segregated from adults. A growth-curve analysis revealed asymptotic body size was attained in approximately 7 years, which is consistent with hadrosaurids from the TMF. The data suggest size–frequency distributions of attritional samples underestimate age and overestimate growth rates, but when paired with osteohistology can provide unique life-history insights.
A SETI survey of the Vela region using the Murchison Widefield Array: Orders of magnitude expansion in search space
Authors: Tremblay C. D. , Tingay S. J. 
Published: September 2020

AbstractFollowing the results of our previous low-frequency searches for extraterrestrial intelligence (SETI) using the Murchison Widefield Array (MWA), directed towards the Galactic Centre and the Orion Molecular Cloud (Galactic Anticentre), we report a new large-scale survey towards the Vela region with the lowest upper limits thus far obtained with the MWA. Using the MWA in the frequency range 98–128 MHz over a 17-h period, a$400\,\textrm{deg}^{2}$field centred on the Vela Supernova Remnant was observed with a frequency resolution of 10 kHz. Within this field, there are six known exoplanets. At the positions of these exoplanets, we searched for narrow-band signals consistent with radio transmissions from intelligent civilisations. No unknown signals were found with a 5$\sigma$detection threshold. In total, across this work plus our two previous surveys, we have now examined 75 known exoplanets at low frequencies. In addition to the known exoplanets, we have included in our analysis the calculation of the Effective Isotropic Radiated Power (EIRP) upper limits towards over 10 million stellar sources in the Vela field with known distances fromGaia(assuming a 10-kHz transmission bandwidth). Using the methods of Wright, Kanodia, & Lubar (2018) to describe an eight-dimensional parameter space for SETI searches, our survey achieves the largest search fraction yet, two orders of magnitude higher than the previous highest (our MWA Galactic Anticentre survey), reaching a search fraction of$\ \sim2\,{\times}\,10^{-16}$. We also compare our results to previous SETI programs in the context of the$\mbox{EIRP}_{\textrm{min}}$—Transmitter Rate plane. Our results clearly continue to demonstrate that SETI has a long way to go. But, encouragingly, the MWA SETI surveys also demonstrate that large-scale SETI surveys, in particular for telescopes with a large field-of-view, can be performed commensally with observations designed primarily for astrophysical purposes.
Obesity, COVID-19 and innate immunometabolism
Authors: Gleeson Laura E. , Roche Helen M. , Sheedy Frederick J. 
Published: September 2020

AbstractAs COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as ‘meta-flammation’, dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention.
Antimicrobial resistance profile of non-aureus Staphylococci isolates from buffalo, goat and sheep mastitis in the Northeast region of Brazil
Authors: Santos André de Souza , Lima Débora Costa Viegas de , Abad Atzel Candido Acosta , Oliveira Pollyanne Raysa Fernandes de , Silva José Givanildo da , Moura Guilherme Santana de , Silva Amanda Thaís Ferreira , Amorim Vinícius da Silva , Costa Mateus Matiuzzi da , Mota Rinaldo Aparecido 
Published: September 2020

AbstractThe study described in this Research Communication investigated the genotypic and phenotypic profiles of resistance to beta-lactams and other antimicrobials in non-aureus Staphylococci (NAS) isolated from buffalo, goat and sheep mastitis in the Northeast region of Brazil. A total of 190 isolates were analyzed and 42.3, 43.9 and 23.6% of them were positive for blaZ gene in buffalo, goat and sheep, respectively. Regarding the animal groups, in goats, amoxicillin was the antimicrobial with highest resistance index (72.7%), followed by penicillin G in buffaloes (51.9%) and ampicillin in sheep (43.1%). With regard to multiple antimicrobial resistance, 30.8% of NAS isolates from buffalo milk samples, 25.8% from goats and 25.0% from sheep presented multidrug-resistance. In the minimum inhibitory concentration (MIC) technique, amoxicillin MIC50 and MIC90 were 64 and 128 μg/ml, respectively, among isolates of the three animal species. In conclusion, high rates of resistance to beta-lactams are presented among NAS isolated from mastitis cases in buffaloes, goats and sheep in Northeast region of Brazil. These results provide an alert to animal and human health researchers, suggesting that the frequency of NAS needs to be reduced because they carry resistance genes which might increase the existing levels of antimicrobial resistance.
Quoting Activity and the Cost of Capital
Authors: Rosu Ioanid , Sojli Elvira , Tham Wing Wah 
Published: September 2020

AbstractWe study the quoting activity of market makers in relation to trading, liquidity, and expected returns. Empirically, we find larger quote-to-trade (QT) ratios in small, illiquid, or neglected firms, yet large QT ratios are associated with low expected returns. The last result is driven by quotes, not by trades. We propose a model of quoting activity consistent with these facts. In equilibrium, market makers monitor the market faster (and thus increase the QT ratio) in neglected, difficult-to-understand stocks. They also monitor faster when their clients are more precisely informed, which reduces mispricing and lowers expected returns.
Autoantibody-associated psychiatric syndromes: a systematic literature review resulting in 145 cases
Authors: Endres Dominique , Maier Viktoria , Leypoldt Frank , Wandinger Klaus-Peter , Lennox Belinda , Pollak Thomas A. , Nickel Kathrin , Maier Simon , Feige Bernd , Domschke Katharina , Prüss Harald , Bechter Karl , Dersch Rick , Tebartz van Elst Ludger 
Published: September 2020

AbstractBackgroundAutoimmune encephalitis (AE) is an important consideration during the diagnostic work-up of secondary mental disorders. Indeed, isolated psychiatric syndromes have been described in case reports of patients with underlying AE. Therefore, the authors performed a systematic literature review of published cases with AE that have predominant psychiatric/neurocognitive manifestations. The aim of this paper is to present the clinical characteristics of these patients.MethodsThe authors conducted a systematic Medline search via Ovid, looking for case reports/series of AEs with antineuronal autoantibodies (Abs) against cell surface/intracellular antigens combined with predominant psychiatric/neurocognitive syndromes. The same was done for patients with Hashimoto encephalopathy/SREAT. Only patients with signs of immunological brain involvement or tumors in their diagnostic investigations or improvement under immunomodulatory drugs were included.ResultsWe identified 145 patients with AE mimicking predominant psychiatric/neurocognitive syndromes. Of these cases, 64% were female, and the mean age among all patients was 43.9 (±22.1) years. Most of the patients had Abs against neuronal cell surface antigens (55%), most frequently against the NMDA-receptor (N= 46). Amnestic/dementia-like (39%) and schizophreniform (34%) syndromes were the most frequently reported. Cerebrospinal fluid changes were found in 78%, electroencephalography abnormalities in 61%, and magnetic resonance imaging pathologies in 51% of the patients. Immunomodulatory treatment was performed in 87% of the cases, and 94% of the patients responded to treatment.ConclusionsOur findings indicate that AEs can mimic predominant psychiatric and neurocognitive disorders, such as schizophreniform psychoses or neurodegenerative dementia, and that affected patients can be treated successfully with immunomodulatory drugs.
The Logic of Vulnerability and Civilian Victimization
Authors: Costalli Stefano , Moro Francesco Niccolò , Ruggeri Andrea 
Published: September 2020

ABSTRACTWhat causes civilian victimization in conventional civil wars and in conventional wars that experience insurgencies? The authors argue that a key driver of civilian victimization is the vulnerability of the incumbent forces, specifically when the conflict’s front line is shifting. Vulnerability is a function of informational and logistical challenges: when the front line is moving, incumbents face increased informational uncertainty and unstable supply chains that augment their vulnerability. Thus, incumbents will increase the use of civilian victimization in response to a scarcity of high-quality information on the location and identity of insurgents, to limit possible information leaks, and to contain supply disruption and logistics support to adversaries. The authors support their argument using matched difference-in-differences analyses of original subnational data on Nazi-Fascist violence in World War II Italy (1943–1945) and qualitative evidence.
Evaluation of precision medicine assessment reports of the Belgian healthcare payer to inform reimbursement decisions
Authors: Govaerts Laurenz , Waeytens Anouk , Van Dyck Walter , Simoens Steven , Huys Isabelle 
Published: September 2020

IntroductionPrecision medicines rely on companion diagnostics to identify patient subgroups eligible for receiving the pharmaceutical product. Until recently, the Belgian public health payer, RIZIV-INAMI, assessed precision medicines and companion diagnostics separately for reimbursement decisions. As both components are considered co-dependent technologies, their assessment should be conducted jointly from a health technology assessment (HTA) perspective. As of July 2019, a novel procedure was implemented accommodating for this joint assessment practice. The aim of this research was to formulate recommendations to improve the assessment in the novel procedure.MethodsThis study evaluated the precision medicine assessment reports of RIZIV-INAMI of the last 5 years under the former assessment procedure. The HTA framework for co-dependent technologies developed by Merlin et al. for the Australian healthcare system was used as a reference standard in this evaluation. Criteria were scored as either present or not present.ResultsThirteen assessment reports were evaluated. Varying scores between reports were obtained for the domain establishing the co-dependent relationship between diagnostic and pharmaceutical. Domains evaluating the clinical utility of the biomarker and the cost-effectiveness performed poorly, whereas the budget impact and the transfer of trial data to the local setting performed well.RecommendationsBased on these results we recommend three amendments for the novel procedure. (i) The implementation of the linked evidence approach when direct evidence of clinical utility is not present, (ii) incorporation of a bias assessment tool, and (iii) further specify guidelines for submission and assessment to decrease the variability of reported evidence between assessment reports.
The role of caregiver speech in supporting language development in infants and toddlers with autism spectrum disorder
Authors: Swanson Meghan R. 
Published: September 2020

AbstractParents play an essential role in supporting child development by providing a safe home, proper nutrition, and rich educational opportunities. In this article we focus on the role of caregiver speech in supporting development of young children with autism spectrum disorder (ASD). We review studies from typically developing children and children with autism showing that rich and responsive caregiver speech supports language development. Autism intervention studies that target caregiver speech are reviewed as are recent scientific advances from studies of typical development. The strengths and weakness of different techniques for collecting language data from caregivers and children are reviewed, and natural language samples are recommended as best practice for language research in autism. We conclude that caregivers play a powerful role in shaping their children's development and encourage researchers to adapt parent-mediated intervention studies to acknowledge individual differences in parents by using a personalized medicine approach.
A conceptual model of risk and protective factors associated with internalizing symptoms in autism spectrum disorder: A scoping review, synthesis, and call for more research
Authors: Yarger Heather A. , Redcay Elizabeth 
Published: September 2020

AbstractThis paper reviews and synthesizes key areas of research related to the etiology, development, and maintenance of internalizing symptoms in children, adolescents, and adults with autism spectrum disorder (ASD). In developing an integrated conceptual model, we draw from current conceptual models of internalizing symptoms in ASD and extend the model to include factors related to internalizing within other populations (e.g., children that have experienced early life stress, children with other neurodevelopmental conditions, typically developing children) that have not been systematically examined in ASD. Our review highlights the need for more research to understand the developmental course of internalizing symptoms, potential moderators, and the interplay between early risk and protective factors. Longitudinal studies incorporating multiple methods and both environmental and biological factors will be important in order to elucidate these mechanisms.
Neuroethics for Fantasyland or for the Clinic? The Limitations of Speculative Ethics
Authors: HANSSON SVEN OVE 
Published: September 2020

AbstractWhat purpose can be served by empirically unsubstantiated speculation in ethics? In answering that question, we need to distinguish between the major branches of ethics. In foundational moral philosophy, the use of speculative examples is warranted to the extent that ethical principles and theories are assumed to be applicable even under the extreme circumstances referred to in these examples. Such an assumption is in need of justification, and it cannot just be taken for granted. In applied ethics, the use of unrealistic scenarios is more difficult to justify. It can be positively harmful if it diverts our attention from more urgent issues. Neuroethics is one of the areas of applied ethics where speculative scenarios have taken up much of the attention that could instead have been devoted to problems that are relevant for the treatment and care of patients. Speculative ethics has often been defended with mere possibility arguments that may at first hand seem difficult to refute. It is shown with examples how such claims can be defeated with a combination of science and argumentation analysis.
Pathologizing the Jíbaro: Mental and Social Health in Puerto Rico's Oso Blanco (1930s to 1950s)
Authors: Ortiz Díaz Alberto 
Published: September 2020

ABSTRACTThe jíbaro—the emblematic figure of Puerto Rico—has long been at the center of the archipelago's political and professional discussions. Building on the work of scholars who have traced the jíbaro's history, this article complicates the tension between the politically nationalistic definition of humble jíbaros working in the countryside and scientific observations of jíbaros within the confines of the criminal-legal system. By the mid twentieth century, mainstream understandings of jíbaros were increasingly fashioned by psychiatry, social science, and social work, all of which connected jíbaros to other rural identities. These projections of the jíbaro powerfully materialized in Puerto Rico's premier biosocial laboratory, the Insular Penitentiary at Río Piedras (popularly known as Oso Blanco). An analysis of the work of penitentiary psychiatrists and social health professionals with prison inmates reveals a more complex, troubling image of redeemable Puerto Rican men with rural roots and sensibilities than the idyllic representations of jíbaros circulating at the time suggest. Oso Blanco health practitioners pathologized the jíbaro to identify and mend his perceived psychosocial shortcomings, and to diminish any defiance he harbored. In so doing, they reinforced the notion that jíbaros were racialized living artifacts central to colonial-populist designs and constituency-building.
Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells
Authors: She Shiqi , Zhao Yang , Kang Bo , Chen Cheng , Chen Xinyu , Zhang Xiaobing , Chen Wenjie , Dan Songsong , Wang Hangxiang , Wang Ying-Jie , Zhao Jinhao 
Published: September 2020

AbstractDespite substantial advances in treating cervical cancer (CC) with surgery, radiation and chemotherapy, patients with advanced CC still have poor prognosis and significantly variable clinical outcomes due to tumor recurrence and metastasis. Therefore, to develop more efficacious and specific treatments for CC remains an unmet clinical need. In this study, by virtual screening the SPECS database, we identified multiple novel JAK inhibitor candidates and validated their antitumor drug efficacies that were particularly high against CC cell lines. AH057, the best JAK inhibitor identified, effectively blocked the JAK/STAT pathways by directly inhibiting JAK1/2 kinase activities, and led to compromised cell proliferation and invasion, increased apoptosis, arrested cell cycles, and impaired tumor progression in vitro and in vivo. Next, by screening the Selleck chemical library, we identified SGI-1027, a DNMT1 inhibitor, as the compound that displayed the highest synergy with AH057. By acting on a same set of downstream effector molecules that are dually controlled by JAK1/2 and DNMT1, the combination of AH057 with SGI-1027 potently and synergistically impaired CC cell propagation via dramatically increasing apoptotic cell death and cell-cycle arrest. These findings establish a preclinical proof of concept for combating CC by dual targeting of JAK1/2 and DNMT1, and provide support for launching a clinical trial to evaluate the efficacy and safety of this drug combination in patients with CC and other malignant tumors.
Subclinical thiamine deficiency identified by pretreatment evaluation in an esophageal cancer patient
Authors: Yoshioka Akira , Sato Izumi , Onishi Hideki , Ishida Mayumi 
Published: September 2020

AbstractDespite the fact that both thiamine deficiency (TD) and Wernicke encephalopathy (WE) have been observed to some degree in cancer patients, such cases of TD and/or WE reported to date have all been diagnosed after the initiation of treatment. We here report a case of TD that presented without the commonly accepted triad of WE symptoms based on a total nutritional evaluation prior to the onset of treatment for cancer. The patient was a 71-year-old man with esophageal cancer who was referred to the oncology outpatient clinic for evaluation to determine the treatment plan. Although he did not present with delirium, cerebellar signs, or ocular symptoms, TD was suspected based on a reduction in appetite lasting 2 months as thiamine stores in the body are depleted in as few as 18 days. Blood findings showed a marked decline in serum thiamine level supported, which the diagnosis of TD. This case revealed the existence of a cancer patient with subclinical TD prior to the onset of treatment for cancer. Due to the fact that TD can occur without the characteristic symptoms as in this case, we believe it is important that total nutritional evaluation of cancer patients always be considered.
Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast
Authors: Bodelon Clara , Oh Hannah , Derkach Andriy , Sampson Joshua N. , Sprague Brian L. , Vacek Pamela , Weaver Donald L. , Fan Shaoqi , Palakal Maya , Papathomas Daphne , Xiang Jackie , Patel Deesha A. , Linville Laura , Clare Susan E. , Visscher Daniel W. , Mies Carolyn , Hewitt Stephen M. , Brinton Louise A. , Storniolo Anna Maria V. , He Chunyan , Chanock Stephen J. , Garcia-Closas Montserrat , Gierach Gretchen L. , Figueroa Jonine D. 
Published: September 2020

AbstractTerminal duct lobular units (TDLUs) are the predominant anatomical structures where breast cancers originate. Having lesser degrees of age-related TDLU involution, measured as higher TDLUs counts or more epithelial TDLU substructures (acini), is related to increased breast cancer risk among women with benign breast disease (BBD). We evaluated whether a recently developed polygenic risk score (PRS) based on 313-common variants for breast cancer prediction is related to TDLU involution in the background, normal breast tissue, as this could provide mechanistic clues on the genetic predisposition to breast cancer. Among 1398 women without breast cancer, higher values of the PRS were significantly associated with higher TDLU counts (P = 0.004), but not with acini counts (P = 0.808), in histologically normal tissue samples from donors and diagnostic BBD biopsies. Mediation analysis indicated that TDLU counts may explain a modest proportion (≤10%) of the association of the 313-variant PRS with breast cancer risk. These findings suggest that TDLU involution might be an intermediate step in the association between common genetic variation and breast cancer risk.