bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection
Authors: Mohamed Amal A. , Moussa Shorouk , Shaheen Mahmoud M. , Abd-Elsalam Sherief , Ahmed Rehab , Mostafa Sahar M. , Fouad Amina , Alegaily Hatem S. , Megahed Samah A. , Abo-Amer Yousry E. 
Published: March 2020

Background & Aims:
Human genetic polymorphism has been reported in the susceptibility and clinical development of infection. In this regard, this study aimed to investigate the link between Vitamin D Receptor (VDR) gene polymorphism and H. pylori infection.

Materials and Methods:
This cross-sectional study was conducted on 224 adult patients with upper gastrointestinal symptoms who underwent an upper gastrointestinal endoscopy between July 2017 and May 2019 in two major university hospitals. All patients were evaluated for helicobacter pylori infection. Two gastric antral biopsy specimens were taken from each patient. One of those Biopsy specimens was evaluated for histopathology examination and the other one was immersed in a saline solution ready for genomic DNA extraction.

Results:
There were statistically significant differences between different genotypes of VDR rs7975232 polymorphism between H. pylori infected and non-infected groups (CC was higher in H. pylori negative and AC and AA were the most common in H. pylori positive group). There were statistical differences between different genotypes of VDR rs2228570 between H. pylori infected and non-infected groups (TT was higher in H. pylori negative and CT and CC were the most common in H. pylori positive group). Regarding VDR rs 7975232 gene polymorphisms; the (A) allele was significantly higher H. pylori infected, while (C) allele was significantly higher in uninfected patients. Regarding VDR rs 2228570 gene polymorphisms; the (C) allele was significantly higher H. pylori infected, while (T) allele was significantly higher in uninfected patients.

Conclusion:
There is a possible association between the FokI and Apal VDR polymorphism and H. pylori infection.
THE STYLES’ VARIATION CONTAINED IN FRENCH MEDIA
Authors: Tobing Roswita Lumban , Rahayu Siti Perdi , Rohali Rohali , Utami Nastiti 
Published: March 2020

The use of language styles has a widely varied purpose to convey information that is not explicitly expressed by the speaker. This study is aimed at describing the form and function of the styles contained in the French media. The subjects of this research are phrases and sentences contained in the CDP Lyrics in the Blonde albums, alcoholic beverages and advertisement aplle in French-language magazines, and in the speech by François Hollande in ‘Le Figaro’ newspaper. Data collection is done by observation and recording techniques using data tables. Data analysis uses the agih method. The analysis of the language style functions is done by using the speech components of SPEAKING. The validity is obtained through semantic validity and reliability through intra-rater reliability. The results of the study show that the style of language in the media is necessary for speech so that the content of communication is more beautiful and attractive. Language style functions depend on the context and purpose of the speech. The most dominant function in the lyrics of the song is the poetic, which prioritizes beauty. In Alcoholic Beverage Ads, the expressive function becomes dominant to make the advertisement more alive. In the Apple Product Advertising on the Internet, the language function is referential for emphasizing the topics described.Keywords: language style, form and function VARIASI GAYA BAHASA DALAM MEDIA PERANCIS AbstrakPenggunaan gaya bahasa mempunyai tujuan yang sangat bervariasi untuk menyampaikan informasi yang tidak akan dinyatakan secara eksplisit oleh si penutur. Penelitian ini bertujuan untuk menjelaskan bentuk dan fungsi gaya bahasa pada media komunikasi yang berupa lagu, iklan, dan Surat Kabar berbahasa Prancis. Subjek penelitian ini adalah frasa dan kalimat yang terdapat dalam Lagu CDP pada album Blonde, iklan minuman beralkohol, iklan aplle dalam majalah berbahasa Prancis, dan Pidato François Hollande dalam Surat Kabar Le Figaro. Pengumpulan data dengan metode simak dan teknik catat dengan tabel data. Analisis data menggunakan metode agih. Penentuan fungsi gaya bahasa menggunakan metode padan referensial. Fungsi penggunaan gaya bahasa dianalisis dengan komponen tutur SPEAKING. Keabsahan data melalui validitas semantis, reliabilitas dengan intra-rater. Hasil penelitian menunjukkan bahasa gaya bahasa yang paling menonjol pada lagu adalah asonansi dan hiperbola, pada iklan minuman beralkohol adalah aliterasi dan hiperbola, pada pidato François Hollande adalah repetisi dan hiperbola, pada iklan apple adalah asonansi dan aliterasi. Fungsi bahasa yang sering muncul adalah referensial kecuali pada iklan minuman beralkohol, yang dominan adalah fungsi emotif. Fungsi gaya bahasa tergantung pada konteks dan tujuan. Gaya bahasa di media diperlukan agar konten indah dan menarik. Kata kunci : Gaya Bahasa, Bahasa Prancis, Bentuk dan Fungsi
Applied Practice and Possible Leverage Points for Information Technology Support for Patient Screening in Clinical Trials: Qualitative Study
Authors: Becker Linda , Ganslandt Thomas , Prokosch Hans-Ulrich , Newe Axel 
Published: March 2020

Background
Clinical trials are one of the most challenging and meaningful designs in medical research. One essential step before starting a clinical trial is screening, that is, to identify patients who fulfill the inclusion criteria and do not fulfill the exclusion criteria. The screening step for clinical trials might be supported by modern information technology (IT).

Objective
This explorative study aimed (1) to obtain insights into which tools for feasibility estimations and patient screening are actually used in clinical routine and (2) to determine which method and type of IT support could benefit clinical staff.

Methods
Semistandardized interviews were conducted in 5 wards (cardiology, gynecology, gastroenterology, nephrology, and palliative care) in a German university hospital. Of the 5 interviewees, 4 were directly involved in patient screening. Three of them were clinicians, 1 was a study nurse, and 1 was a research assistant.

Results
The existing state of study feasibility estimation and the screening procedure were dominated by human communication and estimations from memory, although there were many possibilities for IT support. Success mostly depended on the experience and personal motivation of the clinical staff. Electronic support has been used but with little importance so far. Searches in ward-specific patient registers (databases) and searches in clinical information systems were reported. Furthermore, free-text searches in medical reports were mentioned. For potential future applications, a preference for either proactive or passive systems was not expressed. Most of the interviewees saw the potential for the improvement of the actual systems, but they were also largely satisfied with the outcomes of the current approach. Most of the interviewees were interested in learning more about the various ways in which IT could support and relieve them in their clinical routine.

Conclusions
Overall, IT support currently plays a minor role in the screening step for clinical trials. The lack of IT usage and the estimations made from memory reported by all the participants might constrain cognitive resources, which might distract from clinical routine. We conclude that electronic support for the screening step for clinical trials is still a challenge and that education of the staff about the possibilities for electronic support in clinical trials is necessary.
Sociodemographic Characteristics and Political Attitudes as Correlates of Women Voters’ Electoral Participation in Counties in Kenya
Authors: Okinda Thomas Ibrahim , Ojwang Benson Oduor , Nyambuga Charles Ongadi 
Published: March 2020

This article examines sociodemographic characteristics and political attitudes predicting women voters’ participation in the 2013 general election in Kakamega County, Kenya. Survey data from 372 women voters were collected from this county, the second most populous among the 47 counties in Kenya. Using these data, a two-stage hierarchical multiple regression was conducted with 13 predictors and electoral participation as the dependent variable. In stage one, sociodemographic characteristics accounted for 27 % of the variation in women voters’ electoral participation. In stage two, sociodemographic characteristics and political attitudes contributed to 47 % of the variance in women voters’ participation in the 2013 polls in Kakamega County. Significant predictors of women voters’ electoral participation were: age, education, income, political knowledge, political interest, and sense of civic duty. The article makes recommendations for enhancing women’s electoral participation through legal reforms as well as civic and voter education.
Peran Kepala Sekolah Dalam Peningkatan Mutu Pendidikan Di Sekolah Dasar Muhammadiyah 4 Malang
Authors: Purnomo Wahyudi Setyo Adi , Anshory Ichsan 
Published: March 2020

Abstract: Education is the main thing in Indonesia in improving the quality of human resources. The role of the principal is very important to help improve the quality of education. This study aims to describe 1) the role of the principal in improving the quality of education in elementary schools Muhammadiyah 4 Malang. 2) efforts made by school principals in improving the quality of education in elementary school Muhammadiyah 4 Malang. In this research method using qualitative descriptive methods. The results of the study stated that 1) the role of the headmaster in improving the quality of education in elementary school Muhammadiyah 4 Malang was as a manager, leader, supervisor, administrator, educator, innovator, and motivator. 2) The principal's efforts in improving the quality of education in elementary school Muhammadiyah 4 Malang City include: a) making all improvements in all aspects of improving the quality of education; b) planning and preparing activity plans; c) coordinate the distribution of learning activities; d) supervise and evaluate teachers regarding learning activities; e) coordinate in carrying out all school activities.Keywords: The Role of Principals, Quality of Education, Elementary School Abstrak: Pendidikan merupakan hal utama di Indonesia dalam meningkatkan kualitas sumber daya manusia. Peran kepala sekolah sangat mempengaruhi untuk membantu meningkatkan mutu pendidikan. Penelitian ini bertujuan untuk mendeskripsikan 1) peran kepala sekolah dalam peningkatan mutu pendidikan di sekolah dasar Muhammadiyah 4 Kota Malang. 2) upaya yang dilakukan kepala sekolah dalam peningkatan mutu pendidikan di sekolah dasar Muhammadiyah 4 Kota Malang. Dalam metode penelitian ini menggunakan metode deskriptif kualitatif. Hasil penelitian menyatakan bahwa 1) peran kepala sekolah dalam peningkatan mutu pendidikan di sekolah SD Muhammadiyah 4 Kota Malang adalah sebagai manajer, pemimipin, supervisor, administrator, edukator, inovator dan motivator. 2) Adapun upaya kepala sekolah dalam peningkatan mutu pendidikan di sekolah SD Muhammadiyah 4 Kota Malang diantaranya: a) melakukan semua perbaikan dalam semua aspek peningkatan mutu pendidikan; b) melakukan perencanaan dan penyusunan rencana kegiatan; c) mengkoordinasi pembagian kegiatan pembelajaran; d) melakukan supervise dan evaluasi guru mengenai kegiatan belajar; e) berkoordinasi dalam melakukan semua kegiatan sekolah.Kata kunci: Peran Kepala Sekolah, Mutu Pendidikan, Sekolah Dasar
Analisis Kebijakan Penguatan Pendidikan Karakter Bela Negara Di SMK Sore Tulungagung
Authors: Khusnaini Khusnaini , Nurjaman Asep 
Published: March 2020

Abstract: The Strengthening of National Defense Character Education Policy that has been implemented at the Vocational High School Sore Tulungagung in 2014/2015 is a new character education development policy. The policy must be analyzed to give other schools a clear picture of the effectiveness of character education. Therefore the researcher intends, to find out the implementation suitability and evaluate the effectiveness of the policy of strengthening the character education of the National Defense Vocational High School Sore Tulungagung. Through qualitative research methods, by triangulating research data, researchers analyze data by studying theory through the reduction of interview results. The results obtained, the planning of strengthening the character education of National Defense is not good, because of the lack of reference laws that are used, indicators of achievement of the basic values of the character of defending the country. In the implementation of the policy declared quite good, seen activities that teach nationality insight to students, but there needs to be supervision from the implementation team. Finally, the evaluation stage of the policy is still not good, because the evaluation of character education is in the form of violations in general, not on indicators of the basic values of Defending the State.Keywords: Policy, Character Education, National Defense Abstrak: Kebijakan Penguatan Pendidikan Karakter Bela Negarayang telah dilaksanakan di SMK Sore Tulungagung tahun 2014/2015 merupakan kebijakan pengembangan pendidikan karakter baru. Kebijakan tersebut harus dianalisis agar memberi gambaran jelas kepada sekolah lain efektifitas pendidikan karakter tersebut. Maka dari itu penelitian ini bermaksuduntuk mengetahui implementasi dan mengevaluasi efektifitas kebijakan penguatan pendidikan karakter Bela Negaradi SMK Sore Tulungagung. Melalui metode penelitian kualitatif, dengan triangulasi data-data penelitian, peneliti menganalisis data dengan kajian teori melalui reduksi hasil wawancara. Hasil penelitian yang didapatkan, perencanaan penguatan pendidikan karakter Bela Negarakurang baik, sebab minimnya acuan perundangan yang dipakai, indikator ketercapaian nilai-nilai dasar karakter bela negara. Pada implementasi kebijakan dinyatakan cukup baik, terlihat adanya kegiatan-kegiatan yang mengajarkan wawasan kebangsaan pada peserta didik, namun perlu adanya pengawasan dari tim pelaksana. Terakhir, tahap evaluasi kebijakan masih kurang baik, sebab evaluasi pendidikan karakter ini berupa pelanggaran secara umum, bukan pada indikator nilai-nilai dasar Bela Negara.Kata kunci: Kebijakan, Pendidikan Karakter, Bela Negara
Sand Granules Ekstrak Biji Alpukat (Persea Americana Seed Extract) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue
Authors: Rukminingsih Fef , Pujiastuti Anasthasia 
Published: March 2020

Dengue hemorrhagic fever (DHF) threatens people in the rainy season. DHF is one of the major public health problems in Indonesia. These problems encourage an effort to eradicate Ae. aegypti larvae by using natural larvicide. One of the plants that can be used as natural larvicides is avocado seeds (Persea americana Seed) which contain saponin. This study aims to determine the larvacidal activity of avocado seed extract sandgranules with LC50 of 8.87 mg.mL-1 against Ae. aegypti larvae. This study is an experimental research with a complete random design in a unidirectional pattern. The independent variable in this study is the variation concentration of Explotab as a disintegrant agent ie 2, 3, and 4%. Sand granules of avocado seed extract are made by wet granulation method. Results of the larvacidal activity test of avocado seed extract sand granules were analyzed by calculating the percentage of larvae mortality and statistical analysis using SPSS. The results of this study is the larvacidal activity of pure avocado seed extract with LC50 8.87 mg. L-1 is greater than the avocado seed extract sand granules. The addition of Explotab did not affect the total larvae mortality, but there was a significant difference in larvae mortality at 5 hours of sand granules exposure with explotab concentration of 3% and 4% (a significance value <0.05).
Combination Therapy With Canagliflozin Plus Liraglutide Exerts Additive Effect on Weight Loss, but Not on HbA1c, in Patients With Type 2 Diabetes
Authors: Ali Ali Muhammed , Martinez Robert , Al-Jobori Hussein , Adams John , Triplitt Curtis , DeFronzo Ralph , Cersosimo Eugenio , Abdul-Ghani Muhammad 
Published: March 2020

OBJECTIVE
To examine the effect of combination therapy with canagliflozin plus liraglutide on HbA1c, endogenous glucose production (EGP), and body weight versus each therapy alone.

RESEARCH DESIGN AND METHODS
Forty-five patients with poorly controlled (HbA1c 7–11%) type 2 diabetes mellitus (T2DM) on metformin with or without sulfonylurea received a 9-h measurement of EGP with [3-3H]glucose infusion, after which they were randomized to receive 1) liraglutide 1.2 mg/day (LIRA), 2) canagliflozin 100 mg/day (CANA), or 3) liraglutide 1.2 mg plus canagliflozin 100 mg (CANA/LIRA) for 16 weeks. At 16 weeks, the EGP measurement was repeated.

RESULTS
The mean decrease from baseline to 16 weeks in HbA1c was −1.67 ± 0.29% (P = 0.0001), −0.89 ± 0.24% (P = 0.002), and −1.44 ± 0.39% (P = 0.004) in patients receiving CANA/LIRA, CANA, and LIRA, respectively. The decrease in body weight was −6.0 ± 0.8 kg (P &lt; 0.0001), −3.5 ± 0.5 kg (P &lt; 0.0001), and −1.9 ± 0.8 kg (P = 0.03), respectively. CANA monotherapy caused a 9% increase in basal rate of EGP (P &lt; 0.05), which was accompanied by a 50% increase (P &lt; 0.05) in plasma glucagon-to-insulin ratio. LIRA monotherapy reduced plasma glucagon concentration and inhibited EGP. In CANA/LIRA-treated patients, EGP increased by 15% (P &lt; 0.05), even though the plasma insulin response was maintained at baseline and the CANA-induced rise in plasma glucagon concentration was blocked.

CONCLUSIONS
These results demonstrate that liraglutide failed to block the increase in EGP caused by canagliflozin despite blocking the rise in plasma glucagon and preventing the decrease in plasma insulin concentration caused by canagliflozin. The failure of liraglutide to prevent the increase in EGP caused by canagliflozin explains the lack of additive effect of these two agents on HbA1c.
La muerte en el materialismo filosófico de Gustavo Bueno
Authors: Alvargonzález David 
Published: March 2020

Tras una breve introducción al materialismo filosófico de Gustavo Bueno y a su antropología, se expone su teoría acerca de la diferencia entre individuo humano y persona, y se distingue entre la muerte del individuo humano biológico y el fallecimiento de la persona humana. Se pasa, entonces, a presentar la diferencia entra las normas éticas, morales y políticas, con el objeto de discutir el significado de una muerte buena y un buen fallecimiento desde cada uno de esos tres sistemas axiológicos. Por último, se expone y discute, tanto desde un punto de vista ético como político, la teoría de la «eutanasia procesal» propuesta por Gustavo Bueno.
Dinámica de la otra vida en la filosofía de Unamuno
Authors: Orringer Nelson 
Published: March 2020

Unamuno concibe la otra vida en su óptima forma como un dinamismo en el sentido zubiriano. Ha leído en el Libro de Job la visión de vida y muerte como una conscripción militar o como una contratación laboral. El relato unamuniano «Juan Manso. Cuento de muertos» (1892) rechaza la mansedumbre, favoreciendo una «embestida» existencial antes y después de morir. La crisis de 1897 a 1902 hace a Unamuno temer la nada y buscar alivio en una pasajera conversión al protestantismo liberal. Pero cuando la inseguridad regresa, convierte su incertidumbre de la salvación en punto de partida para su filosofía trágica de la religión. En cuatro sucesivas fases, profundiza cada vez más en su concepción dinámica de la vida eterna: en Vida de Don Quijote y Sancho, en el Tratado del amor de Dios; en Del sentimiento trágico, y en La agonía del cristianismo.
El problema de la muerte en Xavier Zubiri
Authors: Pérez Cornejo Manuel 
Published: March 2020

El artículo analiza el concepto de la «muerte» en la filosofía del pensador español Xavier Zubiri, quien rechazó la habitual división del ser humano en cuerpo (mortal) y alma (inmortal), y propuso una concepción del hombre entendido como «totalidad psico-física». Esta concepción implica necesariamente la mortalidad del individuo, pero bajo la influencia del teólogo francés M.-É. Boismard, Zubiri plantea un concepto de «resurrección» del hombre como un todo, considerando un error hablar solo de una resurrección del cuerpo. Zubiri piensa que, gracias a su libertad, el sujeto puede construir una «figura eterna» de su ser, que permanece para siempre, y alcanza la gracia de la vida eterna, dependiendo de que dicha figura la haya construido el sujeto en versión o aversión hacia la realidad suprema: Dios.
Tensiones entre sindicalismo y feminismos en un periodo de demandas y reivindicaciones para la transformación social
Authors: Rovetto Florencia Laura , Millán Carla Susana 
Published: March 2020

En este artículo se analiza la experiencia de la Central de Trabajadores de la Argentina (CTA) desde sus orígenes (1991) hasta su fractura (2010), tomando aportes de los estudios de género para analizar la incorporación de las demandas y reivindicaciones de las trabajadoras como sujetos políticos en los espacios sindicales, atendiendo a tres aspectos centrales: a) la articulación entre la central sindical y el movimiento de mujeres y feminista, b) la transversalización de la perspectiva de género en sus principales políticas, y c) la participación de las mujeres en las instancias de conducción nacional. Para ello nos valemos de diferentes fuentes bibliográficas, documentales y entrevistas a las dos titulares de la Secretaría de Género e Igualdad de Oportunidades, para recuperar sus miradas acerca de estas cuestiones problemáticas en un contexto atravesado por las tensiones y disputas que confrontan el protagonismo político de los feminismos con las políticas de restauración neoliberal y neopatriarcal, tanto en el país como a nivel global. Del análisis de la experiencia de la CTA se puede ver una propuesta innovadora frente de modelo sindical tradicional con el acento puesto en colectivos sociales emergentes, incorporando, paulatinamente, las causas impulsadas por los movimientos feministas.
Contribuição à crítica do conceito Bildung e o ensino de filosofia em Nietzsche
Authors: Santos Wellington , Costa Marta Rios Nunes da 
Published: March 2020

Este texto analisa a concepção pedagógica do professor-Nietzsche na obra o Futuro de nossos estabelecimentos de ensino (1872) conservando o retrato expositivo-dialógico do Romance de Formação (Bildungsroman) entre o “Filósofo e seus aprendizes”; buscando defender o que chamou-se o daimon-zaratustriano, isto é, os ensinamentos-metodológicos do Espirito-Zaratustra enquanto prática-genealógica para o professor de filosofia no Ensino Médio. Propõe-se, a partir disso, uma leitura-crítica do Ensino de Filosofia sob a perspectiva do vir-a-ser Formação Cultural (Bildung) demonstrando o peso do capital moral para tal.
Palavras-chave: Romance de Formação; Prática-Genealógica; Formação Cultural