bluuebunny/crossref_metadata_2025_split huggingface dataset:
Readiness to try extended-released buprenorphine and related factors of interest: comparison between incarcerated and non-incarcerated subjects with opioid use disorder.
Authors: CHAPPUY Mathieu , MEROUEH Fadi , TROJAK Benoit , BACHELLIER Jérôme , BENDIMERAD Patrick , KOSIM Margaux , HJELMSTROM Peter , NUBUKPO Philippe , BROUSSE Georges , ROLLAND Benjamin 
Published: July 2020

Abstract
Background: Extended-release buprenorphine (XR-BUP) are new pharmaceutical products that offer a one-week-, one-month- or six-months-long buprenorphine treatment for subjects with opioid use disorder (OUD). OUD is frequent in incarcerated populations, and XR-BUP has been suggested to be an interesting treatment option in prison. However, some opioid users have deemed that XR-BUP could constitute a threat to the individual freedom of occasionally using drugs, and was also at risk to be coercively used in some situations. It was thus needed to explore whether incarcerated people with OUD were ready to try XR-BUP formulations, and which reasons could warrant their possible interest or apprehension.Methods: This is a secondary analysis of a survey performed between 12/02/2018 and 05/31/2019 among 366 patients with OUD. Participants were recruited in 68 addiction French settings, among which six were prison medical centers. Bivariable and multivariable comparisons between incarcerated and non-incarcerated interviewees with respect to their readiness to try XR-BUP and the reasons of interest in this new option. Odds ratios and their 95% confidence intervals (aORs; 95%CI) were adjusted for gender, age category, level of education, and type of opioid agonist treatment.Results: The data of 317 participants were included in the analyses. While 108 (48.9%) of the 221 non-incarcerated interviewees declared being ready to try XR-BUP, they were 63.5% (61 out of 96) among those incarcerated (p =0.016). Adjusted comparisons found that incarcerated were significantly less attracted by the potential of XR-BUP to reduce withdrawal symptoms (aOR= 0.54; 95%CI= 0.29 – 0.99), and to reduce misuse of buprenorphine (aOR= 0.56; 95%CI= 0.34 – 0.94), but more attracted by receiving a constantly efficacious treatment for a week or month (aOR= 2.91; 95%CI= 1.21 – 6.98), and have a more discreet treatment (aOR= 1.76; 95%CI= 1.01 – 3.10).Conclusions: Relative to non-incarcerated subjects with OUD, those in prison were readier to try XR-BUP and they seemed more attracted by practicability and discretion features.
A Comparison of Diagnostic Performance of Signal Intensity and Volume Related MRI Multiparameters for Assessing Different Response of Rectal Cancer to Neoadjuvant Chemoradiotherapy
Authors: Tan Zhengwu , Zhang Lan , Cheng Lan , Xie Lingling , Lin Zhenyu , Han Ping , Li Xin 
Published: July 2020

Abstract
Background: “Wait-and-see”, has been proposed as a possible method of treatment in patients with locally advanced rectal cancer (LARC) after chemoradiotherapy (CRT), MR is important to predict the pathological tumor regression grade(TRG) to preoperative CRT. This study aims to evaluate the diagnostic value of signal intensity (SI) and volume (V) change rate in magnetic resonance imaging (MR) and determine which ones perform best as a potential biomarker for predicting pathological TRG to preoperative CRT in patients with LARC.Methods: A retrospective analysis of 82 patients with LARC, for whom clinical and imaging data were retrieved from our institute was conducted between Oct 2017and Oct 2019. Patients underwent pre- and post-CRT T2-weighted (T2W), diffusion-weighted (DW)/apparent diffusion coefficient (ADC) and contrast-enhanced T1-weighted (ceT1W). V, difference of volume between pre-CRT and post-CRT tumor (△V), V of tumor reduction rate (%△V), as well as SI of tumor (SIt), SI of muscle (SIm), relative SI ratio of tumor/muscle (SIR), changed difference SIR between pre- and post-CRT SIR (△SIR), SIR of tumor changed rate (%△SIR) on T2W, ADC and ceT1W were measured. All of LARC after CRT were confirmed pathologically and classifed into histologic TRG: TRG 0 (complete response), TRG 1 (moderate response), TRG 2 (minimal response), TRG 3 (poor response). Descriptive statistics and areas under the receiver operating characteristic curves (ROC) were generated to compare performance of %△V and %△SIR on T2W, DW, ceT1W for distinguishing between different pathological TRG.Result: Of the 82 patients, TRG 0 (16), TRG 1 (15), TRG 2 (35), TRG 3 (16).Except for ADC-%△SIR, the remaining %△V and %△SIR on T1W, ADC/DWI, ceT1W showed statistics significance between four groups. There was not distinguishable between TRG 1 and TRG 2, TRG 2 and TRG 3 by %△V and/ or %△SIR, the remaining different TRG all were identified by %△V and/ or %△SIR on T2W, ADC/DWI, ceT1W. Compared with other individual %△V or %△SIR, the combination of DW-%△V and T2W-%△SIR (DW-%△V * T2W-%△SIR) yielded higher AUCs to predict TRG 0 from TRG 2 (AUCs: 0.954, sensitivity: 93.75%, specificity: 97.14%) and TRG 3 (AUCs: 1.000, sensitivity: 100%, specificity: 100%), although AUC of all had not significant differences between TRG groups. there was statistically significant differences in post-CRT T restage and ypT stage between fours groups, respectively, but the agreement between post-CRT T restage and ypT is low ( kappa=0.191).Conclusions: V and/or SIR change rate on T2W, DW, ceT1W with high diagnostic performance could be useful in differentiating complete response from non-complete response; SIR change rate could be useful for distinguishing between moderate response and poor response.
Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients with Advanced Solid Tumors
Authors: Liu Jingrui , Li Xiaojiao , Zhu Xiaoxue , Chen Hong , Ding Yanhua 
Published: July 2020

Abstract
Background: The presented phase I, first-in-human study evaluated the tolerance, pharmacokinetics, and preliminary efficacy of larotinib mesylate in patients with advanced solid tumors.Methods: Cancer patients were assigned to receive larotinib mesylate at 50–400 mg dose levels until disease progression or intolerance. Dose-limiting toxicities were assessed during Cycles 0 and 1. Pharmacokinetic evaluations were performed after the first dose and at steady-state. Results: Twenty-five patients with solid tumors were enrolled in the dose-escalation study. No DLTs were observed. Acne-like rash (68.0%), diarrhea (48.0%), paronychia (48.0%), and anemia (48.0%) were the most reported treatment-related adverse events. No clear linear pharmacokinetic characteristic could be drawn, and obvious accumulation was observed. Two patients with non-small cell lung cancer experienced a partial response, and 15 patients had stable disease after treatment. Conclusion: Continuous oral administration of larotinib mesylate at 50–400 mg daily demonstrated a favorable safety profile, and anti-tumor activity was observed in patients with advanced solid tumors.Trial registration: registration no.ChiCTR-OPC-15007153, registered 28 September 2015 at http://www.chictr.org.cn
[177Lu]Lu-DOTA-ZOL Bone Pain Palliation in Patients with Skeletal Metastases From Various Cancers: Efficacy and Safety Results
Authors: Yadav Madhav Prasad , Ballal Sanjana , Meckel Marian , Roesch Frank , Bal Chandrashekhar 
Published: July 2020

Abstract
Background: [177Lu]Lu-DOTA-ZOL has shown promising results from the dosimetry and preclinical aspects, but data on its role in the clinical efficacy is limited. In this light, the objective of this study is to evaluate the efficacy and safety of [177Lu]Lu-DOTA-ZOL as a bone pain palliation agent in patients experiencing pain due to skeletal metastases from various cancers.Methods: 40 patients experiencing bone pain due to skeletal metastases were enrolled in this study. The patients were treated with a mean cumulative dose of 2.1 ± 0.6 GBq (1.3–2.7 GBq) [177Lu]Lu-DOTA-ZOL in a median follow-up duration of 10 months (IQR: 8–14 months). The primary outcome endpoint was response assessment according to the visual analog score (VAS). Secondary endpoints included analgesic score (AS), global assessment pain score, Eastern Cooperative Oncology Group Assessment performance status (ECOG), Karnofsky Performance Status (KPS), overall survival, and safety assessment by the National Cancer Institute’s Common Toxicity Criteria V5.0.Results: 40 patients, 15 males, and 25 females with a mean age of 46.6 ± 15.08 years (range: 24–78 years) were treated with either 1 (N = 15) or 2 (N = 25) cycles of [177Lu]Lu-DOTA-ZOL. According to the VAS response assessment criteria, complete, partial, and minimal responses were observed in 11 (27.5%), 20 (50%), and 5 patients (12.5%), respectively with an overall response rate of 90%. Global pain assessment criteria revealed complete, partial, minimal and no response in 2 (5%), 25 (62.5%), 9 (22.5%), and 4 (10%) patients, respectively. Twenty eight patients died and the estimated median overall survival was 13 months (95% CI: 10–14 months). A significant improvement was observed in the VAS, AS and ECOG status when compared to baseline. None of the patients experienced grade III/IV hematological, kidney or hepatotoxicity due to [177Lu]Lu-DOTA-ZOL therapy.Conclusion: [177Lu]Lu-DOTA-ZOL shows promising results and is an effective radiopharmaceutical in the treatment of bone pain due to skeletal metastases from various cancers.
Unraveling the Role of microRNA and isomiRNA Networks in Multiple Primary Melanoma Pathogenesis
Authors: Dika Emi , Broseghini Elisabetta , Porcellini Elisa , Lambertini Martina , Riefolo Mattia , Durante Giorgio , Loher Phillipe , Roncarati Roberta , Bassi Cristian , Misciali Cosimo , Negrini Massimo , Rigoutsos Isidore , Londin Eric , Patrizi Annalisa , Ferracin Manuela 
Published: July 2020

Abstract
Background Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past decades. During their lifetime about 8% of patients with CM will develop multiple primary melanomas (MPM). Patients affected by MPM could have a genetically determined susceptibility, though germline mutations in hereditary melanoma genes are rarely detected. Methods To better characterize the biology of this subset of melanomas, we explored the miRNome of 24 single and multiple primary melanomas, including multiple tumors from the same patient, using a smallRNA sequencing approach and bioinformatic detection of miRNA isoforms. The differential expression of specific miRNAs/isomiRs was obtained using quantitative PCR.Results From a supervised analysis, 22 miRNAs were differentially expressed in MPM compared to single CM, including key miRNAs involved in epithelial-mesenchymal transition (EMT). Moreover, the first and second melanoma from the same patient presented a different miRNA profile. Ten miRNAs, including miR-25-3p, 149-5p, 92b-3p, 211-5p, 125a-5p, 125b-5p, 205-5p, 200b-3p, 21-5p and 146a-5p, were further validated in a larger cohort of single and multiple melanoma samples (N=47). Overall, the Pathway Enrichment Analysis revealed a more differentiated and less invasive status of MPMs. Analyzing our smallRNA seq data, we detected a panel of melanoma-specific miRNA isoforms (isomiRs), which were validated in The Cancer Genome Atlas SKCM cohort. Specifically, we identified hsa-miR-125a-5p|0|-2 isoform as 10-fold over-represented in melanoma and differentially expressed in MPMs. IsomiR-specific target analysis revealed that the miRNA shortening confers a novel pattern of target gene regulations, including genes implicated in melanocyte differentiation and cell adhesion. Conclusions Overall we provided a comprehensive characterization of the miRNA/isomiRNA regulatory network of multiple primary melanomas, highlighting mechanisms of tumor development and correlating miRNA expression with MPM clinical characteristics.
Evaluation Of Clinical Features And Treatment Of Zygomatic Bone Fractures: A 10-Year Retrospective Study
Authors: Iulia Juncar Raluca , Tent Paul Andrei , Mihai Juncar , Anton Arghir Ioan , Oana Arghir Cristina , Mircea Rivis 
Published: July 2020

Abstract
Background
The pattern of zygomatic bone fractures varies in the literature, their features being frequently masked by the presence of associated soft tissue lesions, which make clinical diagnosis and therapeutic indications difficult. The aim of this study was to evaluate the clinical features of zygomatic bone fractures and their interrelation with concomitant overlying soft tissue lesions, in order to improve the diagnosis and the establishment of the correct treatment. We also aimed to assess the type of treatment methods applied depending on the fracture pattern of the zygomatic bone, as well as their effectiveness depending on the incidence rate of postoperative complications.
Methods
A 10-year retrospective evaluation of midface fractures was performed in patients diagnosed and treated in a tertiary Clinic of Oral and Maxillofacial Surgery.
Results
The study included 242 patients with zygomatic bone fractures. The majority of the fractures were displaced n = 179 (73.90%), closed n = 179 (73.90%) and complete n = 219 (90.50%). Hematoma was the most frequent associated soft tissue lesion n = 102 (42.15%) regardless of the fracture pattern (p = 1.000). The incidence of lacerations and excoriations was statistically higher in the case of complete (laceration p = 0.0028/ excoriation p = 0.037), displaced and comminuted zygomatic fractures (laceration p = 0.015/ excoriation p = 0.001). The most frequent type of treatment applied was Gillies reduction (61.98%), followed by ORIF (30.99%). The most frequent postoperative complication was malunion secondary to Gillies treatment (p = 002).
Conclusions
Patients presenting lacerations and excoriations on clinical soft tissue examination will most frequently have an underlying complete, displaced or comminuted zygomatic fracture. The most effective treatment method in the case of displaced, open or comminuted fractures was ORIF, while in the case of non-displaced and closed fractures, conservative treatment was the most effective.
What Influences Modern Contraceptive Utilisation Among Single Mothers in Nigeria? Evidence from Pooled Cross-Sectional Surveys
Authors: Ilesanmi Benjamin Bukky , Solanke Lukman Bola , Musa Musa Balarabe 
Published: July 2020

Abstract
Background: Existing studies in Nigeria and elsewhere have examined the associated factors of modern contraceptive utilisation among different segments of women such as adolescents, never married and women of advanced reproductive age. However, the associated factors of modern contraceptive utilisation among single mothers have been rarely explored. Though, some studies have examined the health and socio-economic conditions of single mothers but the associated factors of modern contraceptive uptake among them were largely ignored. This study therefore examines factors influencing modern contraceptive utilisation among single mothers in Nigeria. Methods: Data were extracted from four consecutive Nigeria Demographic and Health Surveys (NDHSs) implemented between 2003 and 2018. A weighted sample size of 7,215 single mothers was analysed. The outcome variable was current modern contraceptive utilisation. The explanatory variables are sets of selected socio-economic and demographic characteristics such as education, household wealth quintile, place of residence, age, parity and fertility desire. Data analysis was carried out using Stata version 14. Two multivariable logistic regression models were fitted in the study. Results: Findings reveal 11.7% current utilisation of modern contraceptives among single mothers. Improvements in educational attainment and household wealth quintile increases the odds of modern contraceptive use, Muslim single mothers had lower odds of modern contraceptive use (AOR=0.527, p<0.05; 95% CI: 0.366-0.759) and employed single mothers had higher odds of modern contraceptive use (AOR=1.449, p<0.05; 95% CI: 1.123-1.867). Findings further reveal that single mothers who had moderate exposure to the mass media (AOR=1.455, p<0.05; 95% CI: 1.049-1.807), single mothers who had high exposure to the mass media (AOR=1.442, p<0.05; 95% CI: 0.690-1.394) and younger single mothers (AOR=1.377, p<0.05; 95% CI: 1.049-1.807) had higher likelihood of modern contraceptive use. Conclusion: Modern contraceptive utilisation is low among single mothers in Nigeria. A number of socio-demographic characteristics of single mothers exert significant influence on modern contraceptive use. The contraceptive need of women involved in single motherhood may be different from the needs of other groups of women. The development of a special strategy targeting single mothers is thus imperative in the country.
Conventional synthesis of perovskite structured LaTixFe1-xO3: A comprehensive evaluation on phase formation, opto-magnetic, and dielectrical properties
Authors: Raji Ramesh Kumar , Kurapati Vishista , Ramachandran Tholkappiyan , Muralidharan M , Suriakarthick R , Dhilip M , Hamed Fathalla 
Published: July 2020

Abstract
In the current study, we report a comprehensive evaluation of the microstructures, optical, dielectric and magnetic traits of Ti-substituted perovskite structured lanthanum ferrite with chemical compositions LaTixFe1−xO3 (x = 0, 0.05, 0.15, 0.25). X-ray diffraction with Rietveld refinement and Raman analysis confirmed that both pure and Ti-substituted LaFeO3 maintained single-phase orthorhombic phase with Pbnm symmetry. Fourier transform infrared spectroscopy (FTIR) studies revealed the information about the positions of the ions and their bonds within the lattice structure of the LaFeO3. The spherical shaped morphology of all products was confirmed by SEM. The quantitative chemical composition and their distribution were confirmed by EDAX and mapping. The UV-Vis spectroscopic studies showed an excitonic absorption edge at 590 nm is ascribed to the electronic transition from O2p→Fe3d. Optical band gap (Eg) values were assessed by applying Tauc schemes, showed that Eg values are in a narrow range (1.85–2.02 eV). The dielectric properties such as, dielectric constant (ε’), dielectric loss (tan δ) was examined by varying with temperature and frequency. The magnetic results revealed weak ferromagnetic nature trait at 300 K. The variation in Ms (saturation magnetization), Hc (coercivity) and Mr (remanence) values were observed with increasing Ti substitution level.
Health care seeking behavior for common childhood morbidities in Ethiopia: The effects of maternal behavior and access to key health services
Authors: Feng Cindy Xin , Geda Nigatu R , Whiting Susan J , Lepnurm Rein , Henry Carol J , Janzen Bonnie 
Published: July 2020

Abstract
Background: Childhood morbidities such as diarrhea and pneumonia are the leading causes of death in Ethiopia. Appropriate healthcare-seeking behavior of mothers for common childhood illnesses could prevent a significant number of these early deaths; however, little nation-wide research has been conducted in Ethiopia to assess mothers’ healthcare-seeking behavior for their children.Method: The study used the Ethiopian Demographic and Health Surveys (EDHS) conducted in 2016 on a nationally representative sample of 10641 children under the age of five. The main determinants of care-seeking during diarrhea and Acute Respiratory Infection (ARI) episodes were assessed using multiple logistic regression analyses while adjusting for complex survey design.Results: Only 43% and 35% of households sought medical attention for their children in episodes of diarrhea and ARI, respectively, during a reference period of two weeks before the survey. The odds of seeking care for diarrhea are lower for non-working mothers versus working mothers. The likelihood of seeking care for diarrhea or ARI is higher for fathers who had education versus no education. The place of delivery for the child, receiving postnatal checkup and getting at least one immunization in the past determined the likelihood of seeking care for ARI, but not for diarrhea. The odds of seeking care are higher for both diarrhea and ARI among households that are headed by females and where mothers experienced domestic violence. Religion and types of family structure are also significant factors of seeking care for diarrhea episodes, but not for ARI.Conclusion: Given the high morbidity and mortality rates for children in Ethiopia, a deeper understanding of the health-seeking behaviour of mothers may provide insights for identifying the potential gaps and developing improvement of mothers’ awareness and perception towards childhood problems
Differences of tensile strength in knot tying technique between orthopaedic surgical instructors and trainees
Authors: Harato Kengo , Yagi Mitsuru , Kaneda Kazuya , Iwama Yu , Masuda Akihiko , Kaneko Yosuke , Oya Akihito , Matsumura Noboru , Suzuki Taku , Nakayama Robert , Kobayashi Shu 
Published: July 2020

Abstract
Background: Knot tying technique is an extremely important basic skill for all surgeons. Clinically, knot slippage or suture breakage will lead to wound complications. Although some previous studies described the knot-tying technique of medical students or trainees, little information had been reported on the knot-tying technique of instructors. The objective of the preset study was to assess surgeons’ manual knot tying techniques and to investigate the differences of tensile strength in knot tying technique between surgical instructors and trainees.Methods: A total of 48 orthopaedic surgeons (postgraduate year: PGY 2-18) participated. Surgeons were requested to tie surgical knots using same suture material. They were divided into two groups based on each career; instructors and trainees. Although 4 knots with 4 throws were chosen and done with self-selected methods, knot tying practice was done as education only for trainees before the actual trial. The knots were placed over a 30 cm long custom made smooth polished surface with 2 cylindrical rods. All knots were tested for tensile strength using a tensiometer. The surgical loops were loaded until the knot slipped or the suture broke. The tensile strength of each individual knot was defined as the force (N) required to result in knot failure. Simultaneously, knot failure was evaluated based on knot slippage or suture rupture. In terms of tensile strength or knot failure, statistical comparison was performed between groups using two-tailed Mann-Whitney U test or Fisher exact probability test, respectively.Results: Twenty-four instructors (PGY6- PGY18) and 24 trainees (PGY2-PGY5) were enrolled. Tensile strength was significantly greater in trainees (83.0 ± 27.7N) than in instructors (49.9 ± 34.4N, P=0.0246). The ratio of slippage was significantly larger in instructors than in trainees (P<0.001). Knot slippage (31.8 ± 17.7N) was significantly worse than suture rupture (89.9 ± 22.2N, P<0.001) in tensile strength.Conclusions: Mean tensile strength of knots done by trainees after practice was judged to be greater than that done by instructors in the present study. Clinically, knot slippage can lead to wound dehiscence, compared to suture rupture.