bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmic-Ray-driven Outflows from the Large Magellanic Cloud: Contributions to the LMC Filament
Authors: Bustard Chad , Zweibel Ellen G. , D’Onghia Elena , Gallagher III J. S. , Farber Ryan 
Published: April 2020

Abstract
In this paper, we build from previous work and present simulations of recent (within the past Gyr), magnetized, cosmic-ray driven outflows from the Large Magellanic Cloud (LMC), including our first attempts to explicitly use the derived star formation history of the LMC to seed outflow generation. We run a parameter set of simulations for different LMC gas masses and cosmic-ray transport treatments, and we make preliminary comparisons to published outflow flux estimates, neutral and ionized hydrogen observations, and Faraday rotation measure maps. We additionally report on the gas mass that becomes unbound from the LMC disk and swept by ram pressure into the Trailing Magellanic Stream. We find that, even for our largest outburst, the mass contribution to the Stream is still quite small, as much of the outflow-turned-halo gas is shielded on the LMCs far-side due to the LMCs primarily face-on infall through the Milky Way halo over the past Gyr. On the LMC’s near-side, past outflows have fought an uphill battle against ram pressure, with the near-side halo mass being at least a factor of a few smaller than that of the far-side. Absorption-line studies probing only the LMC foreground, then, may be severely underestimating the total mass of the LMC halo formed by outflows.
Estimation of the Physical Parameters of a CME at High Coronal Heights Using Low-frequency Radio Observations
Authors: Mondal Surajit , Oberoi Divya , Vourlidas Angelos 
Published: April 2020

Abstract
Measuring the physical parameters of coronal mass ejections (CMEs), particularly their entrained magnetic field, is crucial for understanding their physics and for assessing their geoeffectiveness. At the moment, only remote sensing techniques can probe these quantities in the corona, the region where CMEs form and acquire their defining characteristics. Radio observations offer the most direct means for estimating the magnetic field when gyrosynchrotron emission is detected. In this work we measure various CME plasma parameters, including its magnetic field, by modeling the gyrosynchrotron emission from a CME. The dense spectral coverage over a wide frequency range provided by the Murchison Widefield Array (MWA) affords a much better spectral sampling than possible before. The MWA images also provide a much higher imaging dynamic range, enabling us to image these weak emissions. Hence we are able to detect radio emission from a CME at larger distances (∼4.73 R
⊙) than have been reported before. The flux densities reported here are among the lowest measured in similar works. Our ability to make extensive measurements on a slow and otherwise unremarkable CME suggests that with the availability of data from the new-generation instruments like the MWA, it should now be possible to make routine, direct detections of radio counterparts of CMEs.
TLR2 2029C/T and TLR3 1377C/T and −7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm
Authors: Jabłońska Agnieszka , Zagrapan Branislav , Neumayer Christoph , Klinger Markus , Eilenberg Wolf , Nanobachvili Josif , Paradowska Edyta , Brostjan Christine , Huk Ihor 
Published: April 2020

Abstract
TLRs are a family of signaling sensors that play a crucial role in the host immune response and are involved in the modulation of inflammatory processes. To study their contribution to abdominal aortic aneurysm (AAA) formation and development, we determined the frequency of TLR2, TLR3, TLR4, and TLR9 single-nucleotide polymorphisms (SNPs) and investigated the association between polymorphisms and the risk of AAA incidence. A total of 104 patients with AAAs and 112 healthy, unrelated volunteers were screened for the presence of TLR2 (2029C/T and 2258G/A), TLR3 (1377C/T, 1234C/T, and −7C/A), TLR4 (896A/G, 1196C/T, and 3266G/A), and TLR9 (−1237T/C, −1486T/C, 1174G/A, and 2848C/T) SNPs by using PCR-RFLP analysis. The heterozygous genotype of the TLR2 2029C/T SNP was more common in patients with AAA than in healthy subjects (p &lt; 0.0001) and was associated with at least an 8-fold increased risk of AAA incidence (p &lt; 0.001). The wild-type genotype of the TLR3 −7C/A SNP was associated with a 3-fold increased risk of hypertension (p = 0.026). The heterozygous TLR3 genotype 1377C/T and −7C/A SNPs were less common in patients with AAA than in healthy subjects (p &lt; 0.0001 and p = 0.0004, respectively) and were associated with a decreased risk of AAA occurrence (p &lt; 0.001 and p = 0.0012, respectively). No relation to AAA risk was found for TLR4 SNPs. Heterozygous genotypes of the TLR2 2029C/T and TLR3 1377C/T and −7C/A SNPs may serve as genetic biomarkers of AAA incidence.
STING Sensing of Murine Cytomegalovirus Alters the Tumor Microenvironment to Promote Antitumor Immunity
Authors: Wilski Nicole A. , Stotesbury Colby , Del Casale Christina , Montoya Brian , Wong Eric , Sigal Luis J. , Snyder Christopher M. 
Published: April 2020

Abstract
CMV has been proposed to play a role in cancer progression and invasiveness. However, CMV has been increasingly studied as a cancer vaccine vector, and multiple groups, including ours, have reported that the virus can drive antitumor immunity in certain models. Our previous work revealed that intratumoral injections of wild-type murine CMV (MCMV) into B16-F0 melanomas caused tumor growth delay in part by using a viral chemokine to recruit macrophages that were subsequently infected. We now show that MCMV acts as a STING agonist in the tumor. MCMV infection of tumors in STING-deficient mice resulted in normal recruitment of macrophages to the tumor, but poor recruitment of CD8+ T cells, reduced production of inflammatory cytokines and chemokines, and no delay in tumor growth. In vitro, expression of type I IFN was dependent on both STING and the type I IFNR. Moreover, type I IFN alone was sufficient to induce cytokine and chemokine production by macrophages and B16 tumor cells, suggesting that the major role for STING activation was to produce type I IFN. Critically, viral infection of wild-type macrophages alone was sufficient to restore tumor growth delay in STING-deficient animals. Overall, these data show that MCMV infection and sensing in tumor-associated macrophages through STING signaling is sufficient to promote antitumor immune responses in the B16-F0 melanoma model.
NKG2Cpos NK Cells Regulate the Expansion of Cytomegalovirus-Specific CD8 T Cells
Authors: Grutza Ralf , Moskorz Wiebke , Senff Tina , Bäcker Eugen , Lindemann Monika , Zimmermann Albert , Uhrberg Markus , Lang Philipp A. , Timm Jörg , Cosmovici Christine 
Published: April 2020

Abstract
Infection with the human CMV associates with phenotypic alterations in lymphocyte subsets. A highly reproducible finding in CMV-seropositive individuals is an expansion of NKG2Cpos NK cells. In this study, we analyzed if the altered NK cell compartment in CMV-seropositive human donors may affect CMV-specific CD8 T cells. Resting CMV-specific CD8 T cells were terminally differentiated and expressed high levels of the NKG2C ligand HLA-E. Activation of CMV-specific CD8 T cells with the cognate Ag further increased HLA-E expression. In line with a negative regulatory effect of NKG2Cpos NK cells on HLA-Ehigh CD8 T cells, depletion of NKG2Cpos NK cells enhanced Ag-specific expansion of CMV-specific CD8 T cells in vitro. In turn, the activation of NK cells in coculture with CMV-specific CD8 T cells promoted a selective loss of HLA-Ehigh CD8 T cells. To test if NKG2Cpos NK cells can target HLA-Ehigh CD8 T cells, Jurkat T cells with and without stabilized HLA-E on the surface were used. NKG2Cpos NK cells stimulated with HLA-Ehigh Jurkat cells released higher levels of Granzyme B compared with NKG2Cneg NK cells and NKG2Cpos NK cells stimulated with HLA-Elow Jurkat cells. Moreover, intracellular levels of caspase 3/7 were increased in HLA-Ehigh Jurkat cells compared with HLA-Elow Jurkat cells, consistent with higher rates of apoptosis in HLA-Ehigh T cells in the presence of NKG2Cpos NK cells. Our data show that NKG2Cpos NK cells interact with HLA-Ehigh CD8 T cells, which may negatively regulate the expansion of CMV-specific CD8 T cells upon activation.
Systematic drug repurposing to enable precision medicine: A case study in breast cancer
Authors: Taylor Krystyna , Das Sayoni , Pearson Matthew , Kozubek James , Strivens Mark , Gardner Steve 
Published: April 2020

Background and Objectives:
Precision medicine and drug repurposing provide an opportunity to ameliorate the challenges of declining pharmaceutical R&D productivity, rising costs of new drugs, and poor patient response rates to existing medications. Multifactorial “disease signatures” provide unique insights into the architecture of complex disease populations that can be used to better stratify patient groups, aiding the delivery of precision medicine.

Methods:
Analysis of a complex disease (breast cancer) population was undertaken to identify the combinations of single-nucleotide polymorphisms that are associated with different disease subgroups. Target genes associated with the disease risk of these subgroups were examined, followed by identification and evaluation of existing active chemical leads as drug repurposing candidates.

Results:
One hundred and seventy-five disease-associated gene targets relevant to different subpopulations of breast cancer patients were identified. Twenty-three of these genes were prioritized as both promising novel drug targets and repurposing candidates. Two targets, P4HA2 and TGM2, have high repurposing potential and a strong mechanistic link to breast cancer.

Conclusions:
This study showed that detailed analysis of combinatorial genomic (and other) features can be used to accurately stratify patient populations and identify highly plausible drug repurposing candidates systematically across all disease-associated targets.
Gelfand Pairs Involving the Wreath Product of Finite Abelian Groups with Symmetric Groups
Authors: Tout Omar 
Published: April 2020

AbstractIt is well known that the pair $(\mathcal {S}_n,\mathcal {S}_{n-1})$ is a Gelfand pair where $\mathcal {S}_n$ is the symmetric group on n elements. In this paper, we prove that if G is a finite group then $(G\wr \mathcal {S}_n, G\wr \mathcal {S}_{n-1}),$ where $G\wr \mathcal {S}_n$ is the wreath product of G by $\mathcal {S}_n,$ is a Gelfand pair if and only if G is abelian.
Enriquecimento semântico para a disponibilização de dados abertos: teoria e prática
Authors: Torino Emanuelle , Trevisan Gustavo Lunardelli , Coneglian Caio Saraiva , Botega Leonardo Castro , Santarem Segundo José Eduardo , Vidotti Silvana Aparecida Borsetti Gregorio 
Published: April 2020

Objetivo: Apresentar o processo de formalização necessário à disponibilização de dados abertos no contexto do linked open data, utilizando-se, neste caso, dados que estão no contexto da pesquisa científica. Método: Para a elaboração do estudo, foram selecionados três datasets, dois disponíveis no portal Dados Abertos CAPES e o terceiro, consiste dos dados do Open Researcher and Contributor ID (ORCID). Como procedimentos metodológicos foram utilizados a pesquisa bibliográfica para embasamento teórico-conceitual do estudo e a pesquisa descritiva para explorar e fornecer informações quanto ao processo de enriquecimento de dados abertos.Resultado: Apresenta como resultado a descrição do processo necessário à disponibilização de um conjunto de dados enriquecido, a partir da modelagem e estruturação, pronto para a conversão ferramental e recuperação.Conclusões: A partir desse estudo, é possível visualizar como ocorre o processo de enriquecimento semântico de dados no contexto do linked open data, abarcando a seleção, análise, processamento e preparação visando a disponibilização, o uso e o reuso.
Ginástica rítmica: experiência baseada nos esportes unificados da Special Olympics
Authors: Leite Elisete De Andrade , Rodrigues José Luiz , Leitão Maria Teresa , Lopes Keyla Ferrari , Carvalho Camila Lopes de 
Published: April 2020

O programa de Esporte Unificado, da Special Olympics, possibilita práticas esportivas para pessoas com e sem deficiência intelectual conjuntamente, visando a promoção da inclusão social. Fundamentado neste programa, foi realizada uma pesquisa-ação objetivando analisar a relação entre atletas com e sem deficiência intelectual em aulas de ginástica rítmica fundamentadas no Esporte Unificado. Para isso, 18 meninas, 12 com deficiência intelectual e 6 sem essa condição, realizaram aulas de ginástica rítmica, conjuntamente, por 12 semanas, com 2 sessões semanais de 2 horas cada, em uma quadra de esportes de Guaratinguetá, São Paulo, Brasil. Ao final do programa, foi empregada uma entrevista semiestruturada com as meninas sem deficiência, apreciando os dados por análise de conteúdo. Os resultados apontaram que a interação entre atletas com e sem deficiência promoveu melhoras na performance das atletas e possibilitou a construção de conhecimento sobre as diversidades, alcançando atitudes de aceitação e respeito pelas diferenças.
Segurança do paciente em serviços de saúde: uma análise na cidade de Salvador, Bahia
Authors: Magalhães Costa Eliana Auxiliadora , Lobão William Mendes , Ribas Camila Lapa Matos , Passos Nathália Muraiviechi 
Published: April 2020

Objetivo: Avaliar a política nacional de segurança do paciente em hospitais de grande porte de Salvador. Método: Estudo de casos múltiplos em hospitais terciários. A coleta de dados ocorreu entre outubro de 2017 e outubro de 2018, com profissionais dos núcleos de segurança do paciente (NSP). Foram analisadas quatro variáveis independentes: constituição dos NSP; ações de planejamento do controle dos eventos adversos (EA); atividades técnico- -operacionais desenvolvidas pelos NSP; e ações de monitoramento dos EA no hospital. Resultados: Dos 20 NSP existentes, estudaram-se 12 (60%). Todos os hospitais possuem NSP constituídos, 91,7% têm plano de segurança do paciente, e 50% contam com profissional com dedicação exclusiva. Das instituições, 58,3% implementam todos os protocolos obrigatórios, sendo identificação do paciente (83,3%) e higienização das mãos (83,3%) os mais frequentes. Os percentuais de EA identificados foram: lesão por pressão (88,9%), queda do leito (77,8%) e erros de medicamentos (75,0%). Conclusão: Os EA aqui referidos sinalizam a necessidade de adequações em prol da segurança do paciente. Os NSP não atendem totalmente às políticas regulatórias vigentes no país, carecendo, portanto, de adequações e de controle sanitário efetivo.
Manual Drawing in Transformation: A Brief Assessment of “Design-by-Drawing” and Potentials of a Body Technique in Times of Digitalization
Authors: Hasenhütl Gert 
Published: April 2020

Abstract
This paper analyzes the transformation of manual drawing in the context of design and art. The historical paradigm shift from “unselfconscious form-making processes” to “design-by-drawing” is closely associated with the current transformation of manual drawing into “digital” or “spatial sketching.” It is argued that design-by-drawing has changed our view of manual drawing as a body technique, for example, from hand–eye coordination more toward an aesthetic perspective by coupling certain forms of attention to this technique. Design-by-drawing is transforming manual drawing into diagramming, coding, or modeling within the paradigm of system design. It becomes obvious that the paradigm shift is not based on disruptive but on incremental innovations since the 1960s. An important focus is on the disparity between a deskilling of classical manual abilities and a reskilling of “body techniques” by the use of innovative man–machine interfaces. By reviewing the pros and cons of manual drawings from the fields of engineering design, graphic design, and art education, future prospects of the use of manual drawings are shown. Examining historical changes in manual drawing can help in understanding current transformations. The arguments presented can contribute to the development of a new framework for the use of this classic technique in design.
BIOSEMIÓTICA: HACIA UNA TEORÍA GENERAL DE LOS SIGNOS DE LA NATURALEZA HUMANA Y NO HUMANA
Authors: ROMERO Javier 
Published: April 2020

Resumen: La biosemiótica es la síntesis de la biología y la semiótica,y su propósito principal es mostrar que la semiosis es un componentefundamental de la vida, es decir, que los signos y el significado de los signosexisten en todos los sistemas vivos. La biosemiótica está experimentandoun interés creciente en semiótica, con notables resultados epistemológicos.En este trabajo hacemos un breve análisis de la biosemiótica para resaltarla novedad de esta teoría a la hora de interpretar las señales de la naturalezahumana y no humana. Abstract: Biosemiotics is the synthesis of biology and semiotics, andits main purpose is to show that semiosis is a fundamental component oflife, i. e., that signs and meaning exist in all living systems. Biosemioticsis experiencing a growing interest in semiotics, with importantepistemological results. This paper makes a brief analysis of biosemioticsto highlight the novelty of this theory when interpreting the signs of humanand non-human nature.
EDUCACIÓN Y NUEVAS METODOLOGÍAS COMUNICATIVAS: FLIPPED CLASSROOM
Authors: POZUELO CEGARRA José María 
Published: April 2020

Resumen: En los últimos años los docentes han visto cómo ha aumentadoconsiderablemente la dificultad para conseguir una comunicación efectivadentro del aula que conlleve a un proceso de enseñanza-aprendizaje eficaz.Los alumnos actuales, especialmente en Educación Primaria, han adquiridoinconscientemente unas habilidades con las nuevas tecnologías que lespermiten acceder a cualquier tipo de información en pocos minutos. Lasmetodologías actuales deben evolucionar para conseguir que los alumnosadquieran un aprendizaje más significativo. La metodología FlippedClassroom es una de ellas, la cual combina el uso de las TIC con unatransmisión de contenidos a través de vídeos. Abstract: In recent years, teachers have seen how the difficulty ofachieving effective communication into the classroom to get an efficientteaching-learning process has increased considerably. Current students,especially in Primary Education, have acquired skills in new technology inan unconscious way, which let them have access to any kind of informationin a few minutes. Current methodologies should be developed more so thatthat pupils can acquire a more significant learning. The Flipped Classroommethodology is one of them, which combines the use of ICTs with the useof videos to transmit the contents.
FLÂNEUR O VOYEUR: LA AMBIGÜEDAD DE LA FIGURACIÓN DEL YO EN VENTANAS DE MANHATTAN (2004), DE ANTONIO MUÑOZ MOLINA
Authors: VULKERS Mieke 
Published: April 2020

Resumen: Generalmente se caracterizan las novelas de Antonio MuñozMolina como híbridos, o sea, la inserción de géneros no-ficcionales en elmarco de una obra novelística. Aunque se presenta Ventanas de Manhattan(2004) solamente como un diario o un libro de viajes, el presente trabajoargumenta que la obra manifiesta una forma genérica híbrida. En base a unmarco teórico, se establecen los componentes que llevan a la caracterizaciónde Ventanas de Manhattan como autoficcional. A continuación, esteartículo se centra en la construcción del yo como una estructura ficcional,fundada en arquetipos literarios. Abstract: The novels of Spanish author Antonio Muñoz Molina generallyare characterized as hybrids, inserting non-fictional genres within theframe of a novelistic work. Although Ventanas de Manhattan (2004) is presented as a diary or even as a travelling journal, this article argues that the work shows a hybrid generic form. Founded upon a theoretical frame, it establishes the components that lead to the characterization of the work as autofictional. Subsequently this article focuses on the construction of the first-person character as a fictional structure, based on literary archetypes.
ANTONIO BUERO VALLEJO EN HUNGRÍA
Authors: KATONA Eszter 
Published: April 2020

Resumen: El objetivo del presente artículo es ofrecer un análisis abarcadorsobre la recepción en Hungría de la obra de Antonio Buero Vallejo.Mencionaremos las once traducciones y, después, examinaremos, a travésde la crítica de la prensa, los cinco estrenos húngaros de sus tres dramas: Enla ardiente oscuridad, puesto en escena dos veces (1962, 1976); El sueñode la razón, montado en 1974; y los dos estrenos de La fundación (1976,1979). Para completar la recepción húngara del autor más destacado delteatro español de la posguerra, repasaremos también algunos escritos quedivulgan su fama en Hungría. Abstract: The aim of this article is to give a comprehensive analysis aboutthe reception of the work of Antonio Buero Vallejo in Hungary. We presentthe eleven translations and then, based on press criticism, analyse the fiveHungarian premieres of three plays: In the Burning Darkness, staged twice(1962, 1976); The Sleep of Reason, debuted in 1974; and two premieresof The Foundation (1976, 1979). To complete the Hungarian image ofthe most prominent author of the post-civil war Spanish theatre, we alsoreview some articles that popularized him in Hungary.
LA AUTONOMÍA DEL GUION CINEMATOGRÁFICO COMO GÉNERO LITERARIO. LA GENIALIDAD CREATIVA DE BUÑUEL Y JULIO ALEJANDRO EN VIRIDIANA (1961)
Authors: JIMÉNEZ GÓMEZ Cristina 
Published: April 2020

Resumen: El guion cinematográfico no constituye un simple instrumentopara la realización final del film, sino que requiere ser estudiado como untexto artístico y como un género literario en sí mismo en tanto que poseeunas características retóricas, estéticas y poéticas que son expresadas através del lenguaje cinematográfico. En el guion cinematográfico deViridiana (1961), Luis Buñuel y Julio Alejandro explotan los recursosretóricos, poéticos y estéticos del texto guionístico para construir laanalogía visual y los significados metafóricos y simbólicos en la estructuranarrativa de su película. Abstract: The screenplay is not a simple instrument for the final realizationof the film, but it needs to be studied as an artistic text and as a literarygenre due to that possesses a rhetorical, aesthetic and poetic characteristicsthat are expressed through the cinematographic language. In the script ofViridiana (1961), Luis Buñuel and Julio Alejandro use the rhetorical, poeticand aesthetic resources of the screenwriting text to construct the visual analogy and the metaphorical and symbolic meanings in the narrative structure of their film.
EL MONÓLOGO DRAMÁTICO EN LA POESÍA ESPAÑOLA CONTEMPORÁNEA: JOSÉ HIERRO Y PEDRO PROVENCIO
Authors: FRÜHBECK MORENO Carlos 
Published: April 2020

Resumen: El objetivo de este artículo es aportar nuevas perspectivassobre la lectura de la poesía con la ayuda de la teoría de la relevancia y laretórica. Con el monólogo dramático como punto de referencia, se prestaráatención al estatuto del poema como texto persuasivo y a la naturaleza dela enunciación. Para terminar, se analizarán dos poemas de José Hierro yPedro Provencio. Abstract: This paper aims to provide new perspectives on reading poetrywith the support of Relevance Theory and Rhetoric. While studyingdramatic monologue, we will focus on the poem as a persuasive text andon the characteristics of enunciation. Last, two poems by José Hierro andPedro Provencio will be analyzed.