bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of application of natural and preformed physical factors at the resort in patients with postolocystectomic syndrome
Authors: Merkulova G. A. , Kaysinova Agnessa Sardoevna , Kudryavtsev A. A. , Fedorova T. E. , Tekeeva F. I. , Ahkubekova N. K. 
Published: September 2020

The objective: to study the effectiveness of natural and preformed physical factors in correcting functional state of liver in patients with postcholecystectomy syndrome.
Material and methods. We examined 80 patients after cholecystectomy at the age of 45.410.2 years. Patients received spa therapy with the use of drinking mineral water Essentuki-Novaya and foam licorice baths (comparison group; n=40) and additionally magnetotherapy on the upper half of the body (main group; n=40).
Results. After the treatment, patients showed a positive dynamics of clinical symptoms of the disease, functional liver tests, lipid metabolism, normalization of lipid peroxidation.
Conclusion. The complex application of natural healing factors and magnetotherapy to patients after cholecystectomy leads to a significant improvement in the basic functions of the hepatobiliary system, normalizes peroxide homeostasis, stabilizes lipid metabolism, prevents the development of inflammatory-degenerative and stagnant phenomena in the biliary system, which prevents the progression of the pathological process.
Immediate and long-term results of physiotherapeutic treatment of patients with chronic constipation in abnormal development of the colon
Authors: Litvinova Olga N. 
Published: September 2020

Background. Currently, the issue of effective conservative treatment of constipation in cases of colon developmental abnormalities remains open.
Aim: to study the immediate and long-term results of the treatment of chronic constipation in case of colon development abnormalities, through individualization of the physiotherapeutic methods used, depending on the type of pathology.
Methods. The article presents the experience of treatment in the Department of Internal Medicine of the Lugansk Republican Clinical Hospital, from 2013 to the present, of 389 patients with chronic constipation in colon developmental abnormalities. We used types of electrical stimulation, different in the method of applying electrodes and the stimulating current parameters. In the work, we used the serial apparatus Endoton 01-B. We evaluated the immediate and long-term results of treatment in the period from 6 months to 3 years.
Results. After 34 courses of rectal electrostimulation of patients with compensated and subcompensated forms of the disease, for 67 months, 346 (88.95%) patients had regular independent defecation with an interval of 2436 hours. The remaining 43 (11.05%) patients with subcompensated and decompensated forms of the disease received 56 courses of rectal electrical stimulation during the year. A persistent positive effect was obtained, namely independent defecation with an interval of 3648 hours.
Conclusion. Rectal electrical stimulation for this pathology is considered the method of choice. The functional immediate and long-term results of rehabilitation of patients confirmed the correctness of the approach chosen.
Possibilities of using the SMARTXIDE2 V2LR laser system after reconstructive plastic surgery with use mesh prostheses for genital prolapse
Authors: Shul’china I. V. , Ishchenko A. I. , Ishchenko A. A. , Gilyadova A. V. 
Published: September 2020

Introduction. Prolapse of pelvic organs is a polyetiological disease, manifested by a displacement of the uterus and he vaginal walls to the genital slit and/or by going beyond it. The urgency of the problem of prolapse of pelvic organ is associated with a tendency for an increase of morbidity in both elderly women due to increased expectancy of life and women of the reproductive period.
Material and methods. The study included 62 patients, age of them was 4275 years. All women were underwent surgical correction with a transvaginal installation of the front mesh implant Gineflex with intraoperative extraction of fragments of the mucous membrane of the anterior wall of vagina with subsequent histological examination, as well as fragments of the mesh prosthesis after its installation and processing of the vaginal mucosa of the SmartXide2 V2LR laser system. Patients were separated on the two group taking into account the operating mode parameters of the fractional CO2 laser. In the 1st group, with a total laser energy of exposure 8.13 J/cm2, included 32 patients, in the 2nd, with a total laser energy of impact 1.48 J/cm2, 30 patients. Transvaginal installation of the anterior mesh prosthesis Gineflex was complemented such the surgical interventions as extraperitoneal ligature hysterosuspension, posterior colporography, colpoperineoplasty, installation of Urosling, Manchester operation, supravaginal uterine amputation, adnexectomy in depending on the accompanied pathology.
Results. In the patients were determined IIIV stages of genital prolapse with using the POP-Q assessment system. During histological examination of a sample of biopsy of the vaginal mucosa, the thickness of walls ranged from 155 to 628 m. During microscopy on fragments of mesh prostheses in the 1st group, fragmentary destruction of the fibers of all formed was noted, which not have been detected in the examination of a samples of patients of the 2nd group, where the total laser energy was less on 6.65 J/m2.
Conclusion. In patients with surgical correction of genital prolapse with using of a mesh implant upon the using the certain characteristics of SmartXide2 V2LR laser system for the exposure of the vaginal mucosa occurs partial destruction of the fibers of the mesh prosthesis, which allows to reduce the degree of tissue tension and consequently allows to reduce the level of complications after surgical diseases is associated with implantation a mesh prosthesis that does not reduce the effectiveness of this surgical treatment. This technique is safe, has no restrictions on the age and somatic status of patients, increases the tolerance of the postoperative period of surgical correction.
Centro Cultural da Juventude
Authors: Vicente Eduardo , Soares Rosana 
Published: September 2020

Este trabalho se propõe a discutir a cultura musical da periferia da cidade de São Paulo (Brasil) através da análise das produções desenvolvidas no Centro Cultural da Juventude (CCJ), um importante espaço cultural público localizado na Zona Norte da cidade. A intenção do texto é concentrar-se na diversidade musical produzida no local ou oferecida em sua programação, entendendo que ela expressa, em grande medida, a riqueza étnica e cultural da metrópole. A escolha do CCJ como ponto de observação privilegiado dessa produção deve-se, em primeiro lugar, ao fato de que o centro é um importante espaço de debate e valorização da música independente do Brasil, organizando frequentemente shows e eventos com artistas e gêneros musicais geralmente distantes do mainstream. Também por essa razão, o Centro possui, desde 2006, um estúdio de gravação onde são produzidos gratuitamente CDs de artistas e bandas da região.
Application of Stochastic Analysis in Project Economics
Authors: Mian M. A. 
Published: September 2020

Summary
The oil and gas industry has come a long way by shifting from the deterministic methods of economic evaluations to probabilistic/stochastic methods. The time is right as the uncertainties keep on increasing and more sophisticated methods/calculations are required for decision-making. The industry is under pressure to maintain its key performance indicator of reserves-to-annual production ratio. New discoveries are becoming scarce, and the size of the discoveries keep on going down. The economics of many discoveries are marginal, and they will require prudent evaluation, planning, and synergies for viable development.
The industry has done a good job in advancing technology, but it is behind in commercial aspects of the business. Due to this lack of expertise, the industry adopts methods and calculations presented by financial/statistical/stock analysts. Although these methods and calculations may suit other industries, they are not directly applicable to the oil and gas industry. Using these methods, without adjusting them to the oil and gas industry’s environment could be damaging to decision-making. Use of methods that are not directly suited to our industry becomes merely an academic exercise and does not add value. In fact, they may have negative impacts on the perceived profitability and result in suboptimal investment decisions and portfolios.
This article shows one such method that is sometimes used by strategists, economists, and planners. The findings in this article will definitely raise concerns and make us think twice about adopting methods from other disciplines without deep scrutiny. The article provides recommendations to alleviate shortcomings in some of the methods applied.
Benchmarking of Pulsed Field Gradient Nuclear Magnetic Resonance as a Demulsifier Selection Tool with Arabian Light Crude Oils
Authors: Marques Debora Salomon , White Ramsey , Al-Khabaz Sajjad , Al-Talaq Mustafa , Al-Buainain Jabr 
Published: September 2020

Summary
The use of chemical demulsifiers in the treatment of crude oil emulsions is an essential step in processing facilities worldwide. Each production facility requires specific demulsifier reformulations as the crude characteristics change. The assessment of candidate demulsifiers before online field trials is currently done with bottle tests. Such tests are manual, based on water dropout visually measured by operators. The development of a method that can automatically determine the speed and amount of water dropout without the laborious need to manually record water separation would significantly decrease human error. Pulsed field gradient nuclear magnetic resonance (PFG-NMR) is used as a classification tool to qualitatively rank the efficiency of different demulsifiers in breaking Arabian Light emulsions. This imaging method can evaluate demulsifier action based on the emulsion characteristics; for example, rate of sedimentation and coalescence and formation of a dense packed zone (rag layer). The results are validated against field trials performed in gas-oil separation plants (GOSPs) at two Saudi Arabian facilities. There was good agreement between the PFG-NMR method and field trials. The results were found to correspond to the water dropout in the first stage of crude oil treatment in processing plants (production traps).
Does socioeconomic status have any influence on success at the national ranking exam?, a prospective survey
Authors: Bouchghoul Hanane , Teboul Jean-Louis , Senat Marie-Victoire , Vigoureux Solene 
Published: September 2020

Abstract
Background: The weight of social inequalities during education is a reality. Students of lower socioeconomic status may have less chance of success in higher education, particularly in medical studies. However, the role of students' socioeconomic factors, such as their parents' profession, in their success in the national ranking exam (NRE) has not been studied.Our aim was to investigate the association between socioeconomic factors and success in the national ranking exam among sixth year medical students at the Paris-Sud Faculty of Medicine.Methods: This was a prospective survey of all sixth-year medical students at the Paris-Sud Faculty of Medicine, using a questionnaire on socioeconomic factors, which were compared according to NRE ranking.Results: Of 172 sixth year medical students, 110 completed the questionnaire. Their ranking ranged from 20 to 7695, with a median of 2815 (interquartile range: 1029-4581). The factors associated with the NRE ranking were a high school diploma (baccalauréat) A or B grade, success at the first attempt in the first-year medical examination, and enrollment in the NRE preparatory lectures during the sixth year of medical training (linear regression, p<0.001). The educational status and socio-professional category of the parents were not associated with the NRE ranking (linear regression, p=0.92).Conclusion: At the Paris-Sud Faculty of Medicine, there was no association between parental socioeconomic status and sixth year students' success in the NRE.
A New Efficient Method to Detect Genetic Interactions for Lung Cancer GWAS
Authors: Luyapan Jennifer , Ji Xuemei , Li Siting , Xiao Xiangjun , Zhu Dakai , Duell Eric J. , Christiani David C. , Schabath Matthew B. , Arnold Susanne M. , Zienolddiny Shanbeh , Brunnström Hans , Melander Olle , Thornquist Mark D. , MacKenzie Todd A. , Amos Christopher I. , Gui Jiang 
Published: September 2020

Abstract
Background: Genome-wide association studies (GWAS) have proven successful in predicting genetic risk of disease using single-locus models; however, identifying single nucleotide polymorphism (SNP) interactions at the genome-wide scale is limited due to computational and statistical challenges. We addressed the computational burden encountered when detecting SNP interactions for survival analysis, such as age of disease-onset. To confront this problem, we developed a novel algorithm, called the Efficient Survival Multifactor Dimensionality Reduction (ES-MDR) method, which used Martingale Residuals as the outcome parameter to estimate survival outcomes, and implemented the Quantitative Multifactor Dimensionality Reduction method to identify significant interactions associated with age of disease-onset.Methods: To demonstrate efficacy, we evaluated this method on two simulation data sets to estimate the type I error rate and power. Simulations showed that ES-MDR identified interactions using less computational workload and allowed for adjustment of covariates. We applied ES-MDR on the OncoArray-TRICL Consortium data with 14,935 cases and 12,787 controls for lung cancer (SNPs = 108,254) to search over all two-way interactions to identify genetic interactions associated with lung cancer age-of-onset. We tested the best model in an independent data set from the OncoArray-TRICL data.Results: Our experiment on the OncoArray-TRICL data identified many one-way and two-way models with a single-base deletion in the noncoding region of BRCA1 (HR = 1.24, P = 3.15 x 10-15), as the top marker to predict age of lung cancer onset.Conclusions: From the results of our extensive simulations and analysis of a large GWAS study, we demonstrated that our method is an efficient algorithm that identified genetic interactions to include in our models to predict survival outcomes.
Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions
Authors: Akahane Toshiaki , Kanomata Naoki , Harada Oi , Yamashita Tetsumasa , Kurebayashi Junichi , Tanimoto Akihide , Moriya Takuya 
Published: September 2020

Abstract
Background: Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor progression and/or drug resistance. However, breast cancer-targeted NGS is not still widely used in clinical practice to compare the genomic profiles of primary breast cancer and recurrent/metastatic lesions.Methods: Triplet samples of genomic DNA were extracted from each patient’s normal breast tissue, primary breast cancer, and recurrent/metastatic lesion(s). A DNA library was constructed using the QIAseq Human Breast Cancer Panel (93 genes, Qiagen) and then sequenced using MiSeq (Illumina). The Qiagen web portal was utilized for data analysis.Results: Successful results for three or four samples (normal breast tissue, primary tumor, and at least one metastatic/recurrent lesion) were obtained for 11 of 35 breast cancer patients with recurrence/metastases (36 samples). We detected shared somatic mutations in all but onepatient, who had a germline mutation in TP53. Additional mutations that were detected in recurrent/metastatic lesions compared with primary tumor were in genes including TP53 (three patients) and one case each of ATR, BLM, CBFB, EP300, ERBB2, MUC16, PBRM1, and PIK3CA. Actionable mutations and/or copy number variations (CNVs) were detected in 73% (8/11) of recurrent/metastatic breast cancer lesions.Conclusions: The QIAseq Human Breast Cancer Panel assay showed that recurrent/metastatic breast cancers sometimes acquired additional mutations and CNV. Such additional genomic changes could provide therapeutic target.
Predicting and Clustering Plant CLE Genes with a New Method Developed Specifically for Short Amino Acid Sequences
Authors: Zhang Zhe , Liu Lei , Kucukoglu Melis , Tian Dongdong , Larkin Robert M. , Shi Xueping , Zheng Bo 
Published: September 2020

Abstract
Background: The CLV3/ESR-RELATED (CLE) gene family encodes small secreted peptides (SSPs) and plays vital roles in plant growth and development by promoting cell-to-cell communication. The prediction and classification of CLE genes is challenging because of their low sequence similarity. Results: We developed a machine learning-aided method for predicting CLE genes by using a CLE motif-specific residual score matrix and a novel clustering method based on the Euclidean distance of 12 amino acid residues from the CLE motif in a site-weight dependent manner. In total, 2156 CLE candidates—including 627 novel candidates—were predicted from 69 plant species. The results from our CLE motif-based clustering are consistent with previous reports using the entire pre-propeptide. Characterization of CLE candidates provided systematic statistics on protein lengths, signal peptides, relative motif positions, amino acid compositions of different parts of the CLE precursor proteins, and decisive factors of CLE prediction. The approach taken here provides information on the evolution of the CLE gene family and provides evidence that the CLE and IDA/IDL genes share a common ancestor. Conclusions: Our new approach is applicable to SSPs or other proteins with short conserved domains and hence, provides a useful tool for gene prediction, classification and evolutionary analysis.
Changes in 3-month mineral and bone disorder patterns were associated with all-cause mortality in prevalent hemodialysis patients with secondary hyperparathyroidism
Authors: Kato Chihiro , Fujii Naohiko , Miyakoshi Chisato , Asada Shinji , Onishi Yoshihiro , Fukuma Shingo , Takanobu Nomura , Michihito Wada , Fukagawa Masafumi , Fukuhara Shunichi , Akizawa Tadao 
Published: September 2020

Abstract
Background. There is limited evidence on the association between short-term changes in mineral and bone disorder parameters and survival in maintenance hemodialysis patients.
Methods. We investigated the association between changing patterns of phosphorus, calcium and intact parathyroid hormone levels and all-cause mortality in hemodialysis patients with secondary hyperparathyroidism. Each parameter was divided into three categories (low [L], middle [M] and high [H]), and the changing patterns between two consecutive visits at 3-month intervals were categorized into nine groups (e.g., L-L and M-H). The middle category was defined as 4.0-7.0 mg/dL for phosphorous, 8.5-9.5 mg/dL for calcium and 200-500 pg/mL for intact parathyroid hormone. Adjusted incidence rates and rate ratios were analyzed by weighted Poisson regression models accounting for time-dependent exposures.
Results. For phosphorus, shifts from low/high to middle category (L-M/H-M) were associated with a lower mortality compared with the L-L and H-H groups, whereas shifts from middle to low/high category (M-L/M-H) were associated with a higher mortality compared with the M-M group. For calcium, shifts from low/middle to high category (L-H/M-H) were associated with a higher mortality compared with the L-L and M-M groups, whereas shifts from high to middle category (H-M) were associated with a lower mortality compared with the H-H group. For intact parathyroid hormone, shifts from low to middle category (L-M) were associated with a lower mortality compared with the L-L group.
Conclusions. Changes in the 3-month patterns of phosphorus and calcium toward the middle category were associated with lower mortality. Our study also suggests the importance of avoiding hypercalcemia.
Profiles of autophagy-related genes in esophageal adenocarcinoma
Authors: Zhu Lei , Dong Lin , Feng Minghao , Yang Fugui , Jiang Wenhao , Huang Zhiyuan , Liu Fabing , Wang Lingwei , Wang Guangxue , Li Qinchuan 
Published: September 2020

Abstract
Background: Several studies have demonstrated autophagy was involved in the process of esophageal adenocarcinoma (EAC). The aim of this study was to explore autophagy-related genes (ARGs) correlated with overall survival (OS) in EAC patients. Methods: Expressions of ARGs in EAC and normal samples were downloaded from TCGA database. GO and KEGG enrichment analyses were used to investigate the ARGs bioinformatics functions. Univariate and multivariate cox regressions were performed to identify prognostic ARGs and the independent risk factors. ROC curve was established to evaluate the feasibility to predict the prognosis. Finally, the correlations between ARGs and clinical features were further explored. In addition， significantly different ARGs were verified in EAC specimens and normal esophageal mucosal tissues. Results: Thirty significantly different ARGs were selected from EAC and normal tissues. Functional enrichments showed these ARGs were mainly related apoptosis. Multivariate cox regression analyses demonstrated eight ARGs were significantly associated with OS. Among these eight genes, BECN1 (HR=0.321, P=0.046), DAPK1 (HR=0.636, P=0.025) and CAPN1 (HR=0.395, P=0.004) played protective roles in survival. Gender (HR=0.225, P=0.032), stage (HR=5.841, P=0.008) and risk score (HR=1.131, P＜0.001) were independent prognostic risk factors. ROC curves showed better efficacy to predict survival using the risk score. Additionally, we found BECN1, DAPK1, VAMP7 and SIRT1 genes were correlated significantly with survival status, gender, primary tumor and tumor stage (all P ＜0.05). The experimental results confirmed the BIRC5 was overexpressed and the ITPR1, PRKN were downregulated in the EAC tissues compared with the normal esophageal mucosal tissues (all P＜0.05). Conclusion: Our findings suggested that autophagy was involved in the process of EAC. Several ARGs probably could serve as diagnostic and prognostic biomarkers and may help facilitate therapeutic targets in EAC patients.