bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nowcasting the COVID‐19 pandemic in Bavaria
Authors: Günther Felix , Bender Andreas , Katz Katharina , Küchenhoff Helmut , Höhle Michael 
Published: December 2020

AbstractTo assess the current dynamics of an epidemic, it is central to collect information on the daily number of newly diseased cases. This is especially important in real‐time surveillance, where the aim is to gain situational awareness, for example, if cases are currently increasing or decreasing. Reporting delays between disease onset and case reporting hamper our ability to understand the dynamics of an epidemic close to now when looking at the number of daily reported cases only. Nowcasting can be used to adjust daily case counts for occurred‐but‐not‐yet‐reported events. Here, we present a novel application of nowcasting to data on the current COVID‐19 pandemic in Bavaria. It is based on a hierarchical Bayesian model that considers changes in the reporting delay distribution over time and associated with the weekday of reporting. Furthermore, we present a way to estimate the effective time‐varying case reproduction number based on predictions of the nowcast. The approaches are based on previously published work, that we considerably extended and adapted to the current task of nowcasting COVID‐19 cases. We provide methodological details of the developed approach, illustrate results based on data of the current pandemic, and evaluate the model based on synthetic and retrospective data on COVID‐19 in Bavaria. Results of our nowcasting are reported to the Bavarian health authority and published on a webpage on a daily basis (https://corona.stat.uni-muenchen.de/). Code and synthetic data for the analysis are available from https://github.com/FelixGuenther/nc_covid19_bavaria and can be used for adaption of our approach to different data.
Bone Regeneration of Maxillary Molar Proximal Class 2 Furcation Defects Treated With Microscope‐Assisted Papilla Preservation Technique and DFDBA: A Case Series
Authors: Do Jonathan H. 
Published: December 2020

IntroductionPeriodontal regeneration of maxillary molar proximal furcation defects are challenging due to limited access. While combination therapy of open flap debridement with barrier membrane, bone graft, and biologics are reported to be more successful than monotherapeutic approaches, combination therapy can be complicated and costly.Case PresentationA total of four teeth in three patients are presented to demonstrate radiographic bone regeneration of deep Class 2 maxillary molar proximal furcation defects (MMPFD) treated with microscope‐assisted papilla preservation technique (PPT) and demineralized freeze‐dried bone allograft (DFDBA).Conclusion(s)Radiographic bone regeneration of deep Class 2 MMPFD is possible with microscope‐assisted PPT and DFDBA. Furthermore, treatment outcomes appear to be superior to those from previous clinical trials of Class 2 MMPFD treatment.
Toward a head movement‐based system for multilayer digital content exploration
Authors: Bruno Alessandro , Moore Morgan , Zhang Jinglu , Lancette Stéphane , Ward Ville P. , Chang Jian 
Published: December 2020

AbstractIn this article, we propose a novel technique based on Head Movement tracking to explore multilayer digital content. We extend an existing method by Kazemi et al. dealing with the extraction of facial landmarks to define the “head‐gaze” of the user. We use the “head‐gaze” to calculate the users' on‐screen coordinates. Hovering the cursor over an interactive area for a given time threshold allows users to explore the next layer contents. Our experimental sessions allowed us to measure the technique's level of control and usability. Our results were promising, and users were able to interact with considerably small regions. Furthermore, our lightweight method can be used with a low‐cost camera or webcam and a wide range of screen sizes and distances.
Homotopic reduction in laser‐evoked potential amplitude and laser‐pain rating by abdominal acupuncture
Authors: Valeriani Massimiliano , Liguori Stefano , Vollono Catello , Testani Elisa , Bangrazi Sergio , Petti Filomena , Liguori Aldo , Germanotta Marco , Padua Luca , Pazzaglia Costanza 
Published: December 2020

AbstractBackgroundThe neural mechanism underlying the analgesic effect of acupuncture is largely unknown. We aimed at investigating the effect of abdominal acupuncture (AA) on the laser‐evoked potential (LEP) amplitude and laser‐pain rating to stimulation of body parts either homotopic or heterotopic to the treated acupoint.MethodsLaser‐evoked potentials were recorded from 13 healthy subjects to stimulation of the right wrist (RW), left wrist (LW) and right foot (RF). LEPs were obtained before, during and after the AA stimulation of an abdominal area corresponding to the representation of the RW. Subjective laser‐pain rating was collected after each LEP recording.ResultsThe amplitude of the N2/P2 LEP component was significantly reduced during AA and 15 min after needle removal to both RW (F = 4.14, p = .02) and LW (F = 5.48, p = .008) stimulation, while the N2/P2 amplitude to RF stimulation (F = 0.94, p = .4) remained unchanged. Laser‐pain rating was reduced during AA and 15 min after needle removal only to RW stimulation (F = 5.67, p = .007).ConclusionOur findings showing an AA effect on LEP components to both the ipsilateral and contralateral region homotopic to the treated area, without any LEP change to stimulation of a heterotopic region, suggest that the AA analgesia is mediated by a segmental spinal mechanism.SignificanceAlthough abdominal acupuncture has demonstrated to be effective in the reduction in laser‐evoked potential (LEP) amplitude and laser‐pain rating, the exact mechanism of this analgesic effect is not known. In the current study, we found that treatment of an area in the “turtle representation” of the body led to a topographical pattern of LEP amplitude inhibition that can be mediated by a segmental spinal mechanism.
Construction of N, S‐co‐doped graphene/polyaniline composite as free‐standing electrode material
Authors: Du Xiangxiang , Shi Xuejun , Li Yanling , Cao Kesheng 
Published: December 2020

SummaryHerein, N, S‐co‐doped graphene hydrogel (N/SGH) was first prepared by one‐pot feasible hydrothermal approach using thiourea as a dopant for both N and S sources. And then, polyaniline (PANI) was grown on the surface of N, S‐co‐doped graphene hydrogel via simple adsorption of aniline monomer and in situ polymerization process. The N, S‐co‐doped graphene/polyaniline (N/SGH/PANI) composite hydrogel was fabricated as a free‐standing and binder‐free electrode material. Due to the co‐doped synergistic effect, the N/SGH electrode exhibited enhanced electrochemical performances. The N/SGH electrode displays a specific capacitance of 130.4 F/g at 0.5 A/g. Compared with pure graphene hydrogel (GH), the specific capacitance of N/SGH and N‐doped graphene (NGH) electrodes at 0.5 A/g increased by 53% and 20%, respectively. PANI pseudocapacitor material was introduced to further improve its capacitive performance. The resultant N/SGH/PANI composite electrode could achieve a max specific capacitance of 236.5 F/g at 0.5 A/g. In addition, N/SGH/PANI composite electrode showed stable cycle performance with the capacity retention of 95.1% after 1000 cycles performed at 10 A/g. Those provide a fabrication strategy for the design of high‐performance supercapacitors electrode materials.
A formal adversarial perspective: Secure and efficient electronic health records collection scheme for multi‐records datasets
Authors: Kanwal Tehsin , Anjum Adeel , Khan Abid , Asheralieva Alia , Jeon Gwanggil 
Published: December 2020

AbstractThe collection of private health data without compromising privacy is an imperative aspect of privacy‐aware data collection mechanisms. Privacy‐preserved data collection is achieved by anonymizing private data before its transmission from data holders to data collectors. Though there exist ample literature on private data collection for 1:1 (single record of a data holder) datasets, collecting multi‐records (multiple records of a data holder) datasets (referred to as 1:M datasets) has not received due attention from the research community. Therefore, the current studies experience serious privacy breaches in 1:M dataset thereby limiting their application in secure healthcare applications and systems. In this work, we have formally classified main privacy disclosures on these data collection mechanisms and proposed an improved privacy scheme, namely, horizontal sliced permuted permutation (H‐SPP) for 1:M datasets. It uses the composite slicing and anatomy‐based approach to protect against the privacy violations like identity, attribute, and membership disclosures. Moreover, we perform formal modeling of the proposed scheme using high‐level Petri nets (HLPN) and show that it effectively prevents the identified external and internal privacy attacks. Experimental results show that H‐SPP provides robust privacy for health data with high performance.
Instanton calculations of tunneling splittings in chiral molecules
Authors: Sahu Nityananda , Richardson Jeremy O. , Berger Robert 
Published: December 2020

AbstractWe report the ground state tunneling splittings (ΔE±) of a number of axially chiral molecules using the ring‐polymer instanton (RPI) method (J. Chem. Phys., 2011, 134, 054109). The list includes isotopomers of hydrogen dichalcogenides H2X2 (X = O, S, Se, Te, and Po), hydrogen thioperoxide HSOH and dichlorodisulfane S2Cl2. Ab initio electronic‐structure calculations have been performed on the level of second‐order Møller–Plesset perturbation (MP2) theory either with split‐valance basis sets or augmented correlation‐consistent basis sets on H, O, S, and Cl atoms. Energy‐consistent pseudopotential and corresponding triple zeta basis sets of the Stuttgart group are used on Se, Te, and Po atoms. The results are further improved using single point calculations performed at the coupled cluster level with iterative singles and doubles and perturbative triples amplitudes. When available for comparison, our computed values of ΔE± are found to lie within the same order of magnitude as values reported in the literature, although RPI also provides predictions for H2Po2 and S2Cl2, which have not previously been directly calculated. Since RPI is a single‐shot method which does not require detailed prior knowledge of the optimal tunneling path, it offers an effective way for estimating the tunneling dynamics of more complex chiral molecules, and especially those with small tunneling splittings.
Retracted: Extracellular vesicle‐encapsulated microRNA‐425‐derived from drug‐resistant cells promotes non‐small–cell lung cancer progression through DAPK1‐medicated PI3K/AKT pathway
Authors: Guo Zhihua , Ye Huangyang , Zheng Xiaobin , Yin Weiqiang , He Jianxing 
Published: December 2020

AbstractInvestigations in the area of tumor‐derived extracellular vesicles (EVs) open a new horizon in developing cancer biology and its potential as cancer biomarkers. Following this prospect, we aimed to identify that the role of successfully isolated EVs from drug‐resistance cells in the progression of non‐small–cell lung cancer (NSCLC). P‐EVs and R‐EVs secreted by A549 cells and drug‐resistant A549‐R cells respectively were extracted and characterized. The targeting relationship between miR‐425 and MED1 was verified. Cell proliferation, invasion, migration and apoptosis after treatment of P‐EVs, R‐EVs, miR‐425 inhibitor, miR‐425 mimic, pcDNA‐MED1, or phosphatidylinositol‐3‐kinase (PI3K)/AKT inhibitor LY294002 were detected. Furthermore, xenograft tumor in nude mice was established for further confirming our in vitro findings. P‐EVs and R‐EVs were successfully extracted and could be internalized by A549 cells. A549‐R cells and R‐EVs showed higher miR‐425 expression compared with A549 cells and P‐EVs, respectively. miR‐425 delivered by R‐EVs could promote the proliferation, migration, and invasion, while inhibit apoptosis of NSCLC cells. MED1 was the target gene of miR‐425. EVs‐encapsulated miR‐425‐derived from A549‐R cells could promote the progression of NSCLC in vivo through regulating DAPK1‐medicated PI3K/AKT pathway. Moreover, miR‐425 delivered by R‐EVs promoted tumorigenesis in vivo. Taken together, the result suggested that EVs‐delivered miR‐425‐derived from A549‐R cells promoted the progression of NSCLC through regulating DAPK1‐medicated PI3K/AKT signaling pathway.
Histomorphological investigations on the lips of Rahmani sheep (Ovis aries): A scanning electron and light microscopic study
Authors: Madkour Fatma A. , Mohammed Elsayed S. I. 
Published: December 2020

AbstractThis study was conducted to provide comprehensive information on the anatomical and histological features of the upper (UL) and lower (LL) lips of Rahmani sheep by gross examination, morphometric analysis in addition to Light and scanning electron microscope (SEM). Samples from normal healthy adult male sheep heads were collected directly after slaughtering. UL and LL were dissected, and specimens were collected for both light and SEM. The UL was longer approximately by one‐fold and thicker by one‐fold at the median and the oral angle areas, and by one‐ and half‐folds at the paramedian area than the LL. The free border of both lips was characterized rostrally by the presence of labial projections. By SEM the edges of the inner aspect of the lips and of the philtrum were distinguished by labial projections. These projections which surrounding the philtrum subdivided into polygonal areas with numerous keratinized scales especially at the apical parts which increased dorsally toward the nostril. Most of the openings of the upper labial salivary glands were volcanic crater‐shaped while that of the lower labial salivary glands were various shapes; round folded margin, rosette and whirlpool shaped. Histologically, the shape of the projection or papillae differs at the median and paramedian areas of the UL than the LL. However, there was no differences near the oral angle area. In conclusion, the shape, size and amount of keratinization of the papillae may offer efficiency to the lips during feeding process.
Electromagnetic port boundary conditions: Topological and variational perspective
Authors: Hiptmair Ralf , Ostrowski Jörg 
Published: December 2020

AbstractWe present a comprehensive and variational approach to the coupling of electromagnetic field models with circuit‐type models. That coupling relies on integral nonlocal quantities like voltage and current for electric ports, magnetomotive force, and magnetic flux for magnetic ports, and linked currents and fluxes for “tunnels” in the field domain. These quantities are closely linked to nonbounding cycles studied in algebraic topology and they respect electromagnetic power balance laws. We obtain two dual variational formulations, called E‐based and H‐based, which provide a foundation for finite‐element Galerkin discretization.
Evaluating the effect of neoadjuvant chemotherapy on surgical outcomes after breast conserving surgery
Authors: Woeste Matthew R. , Bhutiani Neal , Donaldson Marilyn , McMasters Kelly M. , Ajkay Nicolás 
Published: December 2020

AbstractBackgroundNeoadjuvant chemotherapy (NAC) increases breast‐conserving surgery (BCS) rates with comparable locoregional control and survival outcomes to adjuvant therapy. More women are receiving NAC and achieving pathologic complete responses (pCR). This study sought to evaluate the effect of NAC on surgical outcomes after the adoption of a “no‐ink‐on‐tumor” margin policy in patients undergoing primary BCS (PBSC).MethodsAn IRB approved database was queried for women undergoing BCS for invasive breast cancer after March 2014. We compared patients who underwent NAC followed by BCS versus PBCS. Demographic, tumor, treatment, and outcome variables were compared using both univariate and multivariable analysis.ResultsA total of 162 patients were evaluated. NAC patients had significantly lower re‐excision rates (0% NAC vs. 9% PBCS, p = .03), margin positivity (0% NAC vs. 5% PBCS, p = .01), and greater patient satisfaction with breast cosmesis (97 NAC vs. 77 PBCS, p = .01). On multivariable analysis, NAC was not an independent predictor of lower final resection volume, total complications, or greater satisfaction with breasts when controlling for age and T category at diagnosis.ConclusionNAC followed by BCS may offer less margin positivity, lower re‐excision rates, and greater patient satisfaction when compared to a contemporary PBCS cohort in the “no‐ink‐on‐tumor” era.
Clinical significance of indeterminate pulmonary nodules on the survival of 364 patients with nonmetastatic, high‐grade, localized osteosarcoma: A 12‐year retrospective cohort study
Authors: Zhou Chenliang , Wang Yiyun , Qian Guowei , Li Hongtao , Yu Wenxi , Shen Zan , Zheng Shuier , Wang Yonggang 
Published: December 2020

AbstractBackground and ObjectivesWe investigated the clinical significance of indeterminate pulmonary nodules (IPNs) in patients diagnosed with nonmetastatic, high‐grade localized osteosarcoma.MethodsWe retrospectively analyzed the clinical data of 364 patients with nonmetastatic, high‐grade localized osteosarcoma. Based on pulmonary computed tomography findings at presentation, the patients were categorized into the no‐nodules and the IPNs group and were further categorized into subgroups based on age (<18 and ≥18 years). We performed an intergroup comparison of event‐free survival (EFS) and overall survival (OS).ResultsAt presentation, 276 (75.8%) patients showed no nodules, and 88 (24.2%) patients showed IPNs. The EFS and OS were similar between adults with IPNs (n = 54 [30.5%]) and without nodules (n = 123 [69.5%]) (p = .200 and p = .609, respectively). No significant intergroup difference in OS was observed in pediatric patients (p = .093). However, pediatric patients with IPNs (n = 34 [18.2%]) had poorer EFS than those without nodules (n = 153 [81.8%]) (p = .016). Multivariate analyses confirmed that IPNs were independently associated with poorer EFS in pediatric patients (hazard ratio 1.788, 95% confidence interval 1.092–2.926, p = .021).ConclusionsThis study showed that IPNs at presentation did not affect the survival of adults with nonmetastatic, high‐grade localized osteosarcoma but were associated with poorer EFS in pediatric patients.
Anthropogenic nitrogen is changing the East China and Yellow seas from being N deficient to being P deficient
Authors: Moon Ji‐Young , Lee Kitack , Lim Weol‐Ae , Lee Eunil , Dai Minhan , Choi Yang‐Ho , Han In‐Seong , Shin Kyoungsoon , Kim Ja‐Myung , Chae Jinho 
Published: December 2020

AbstractAddition of the increased anthropogenic nitrogen (NOx and NHy) emitted from northeast Asian countries to the Yellow and East China seas and coastal waters around Korea has resulted in an unparalleled increase in the nitrate (N) concentration relative to the phosphate (P) and silicate (Si) concentrations in the upper ocean. We found that for the Yellow Sea the increase in N over P was largely explained by increased atmospheric nitrogen deposition, whereas for the northern East China Sea, downstream of the Changjiang River plume, the trend in N increase relative to P was more associated with a change in the combined input of nutrients from atmospheric deposition and riverine discharges. In contrast, the dynamics of the N to P relationship in the southern East China Sea was largely controlled by a change in the intrusion intensity of the Kuroshio Current, which has a low N : P ratio. The disproportionate and persistent input of nutrients to the marine waters of this region over the past four decades has transformed extensive areas from being N deficient to being P deficient, and has concurrently decreased the concentration of Si relative to N. In coastal waters around Korea in particular, these shifts in the nutrient regime have been accompanied by a change from diatom‐dominated to dinoflagellate‐dominated blooms. Given the complexity of coastal ecosystems, the associations between changes in nutrient regimes and biological changes need to be investigated in other coastal areas receiving increasing loads of anthropogenic nitrogen.
Synthesis of Quasi‐Bilayer Subnano Metal‐Oxide Interfacial Cluster Catalysts for Advanced Catalysis
Authors: Chen Si , Huang Li , Sun Zhihu , Cao Lina , Ying Wenxiang , Shi Xianxian , Liu Wei , Gu Jian , Zheng Xusheng , Zhu Junfa , Lin Yue , Wei Shiqiang , Lu Junling 
Published: December 2020

AbstractPlanar metal clusters possess high metal utilization, distinct electronic properties, and catalytic functions from their 3D counterparts. However, synthesis of these materials is challenging due to much elevated surface free energies. Here it is reported that silica supported planar bilayer Pt‐CoOx subnano clusters, consisting of approximately one atomic layer of Pt and one CoOx layer on top, can be achieved by employing strong‐electrostatic interactions during impregnation and precisely‐controlled CoOx coating using atomic layer deposition. Such bilayer structure is unambiguously confirmed by electron microscopy and in situ X‐ray absorption fine spectroscopy which is never reported before. This synthetic approach can be extended to another eight permutations of planar metal‐oxide subnano clusters. The resulting bilayer catalysts, owing to unique electronic properties and the abundant metal‐oxide interfaces created, exhibit excellent catalytic performances in the reactions of preferential oxidation of CO in H2 and selective hydrogenation of acetylene, by showing much higher selectivity and intrinsic activities at least 8 and 48 times greater than those conventional oxide coated 3D metal clusters/nanoparticles, highlighting the advances of bilayer interfacial structure. These findings open a new avenue to design abundant and highly active metal‐oxide interfaces for advanced metal catalysis.
Algebraic Approach to Bose–Einstein Condensation in Relativistic Quantum Field Theory: Spontaneous Symmetry Breaking and the Goldstone Theorem
Authors: Brunetti Romeo , Fredenhagen Klaus , Pinamonti Nicola 
Published: December 2020

AbstractWe construct states describing Bose–Einstein condensates at finite temperature for a relativistic massive complex scalar field with $$|\varphi |^4$$

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φ
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4

-interaction. We start with the linearized theory over a classical condensate and construct interacting fields by perturbation theory. Using the concept of thermal masses, equilibrium states at finite temperature can be constructed by the methods developed in Fredenhagen and Lindner (Commun Math Phys 332:895, 2014) and Drago et al. (Ann Henri Poincaré 18:807, 2017). Here, the principle of perturbative agreement plays a crucial role. The apparent conflict with Goldstone’s theorem is resolved by the fact that the linearized theory breaks the U(1) symmetry; hence, the theorem applies only to the full series but not to the truncations at finite order which therefore can be free of infrared divergences.