bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol consumption in later life and reaching longevity: the Netherlands Cohort Study
Authors: van den Brandt Piet A , Brandts Lloyd 
Published: January 2020

Abstract

Background
whether light-to-moderate alcohol intake is related to reduced mortality remains a subject of intense research and controversy. There are very few studies available on alcohol and reaching longevity.

Methods
we investigated the relationship of alcohol drinking characteristics with the probability to reach 90 years of age. Analyses were conducted using data from the Netherlands Cohort Study. Participants born in 1916–1917 (n = 7,807) completed a questionnaire in 1986 (age 68–70 years) and were followed up for vital status until the age of 90 years (2006–07). Multivariable Cox regression analyses with fixed follow-up time were based on 5,479 participants with complete data to calculate risk ratios (RRs) of reaching longevity (age 90 years).

Results
we found statistically significant positive associations between baseline alcohol intake and the probability of reaching 90 years in both men and women. Overall, the highest probability of reaching 90 was found in those consuming 5– &lt; 15 g/d alcohol, with RR = 1.36 (95% CI, 1.20–1.55) when compared with abstainers. The exposure-response relationship was significantly non-linear in women, but not in men. Wine intake was positively associated with longevity (notably in women), whereas liquor was positively associated with longevity in men and inversely in women. Binge drinking pointed towards an inverse relationship with longevity. Alcohol intake was associated with longevity in those without and with a history of selected diseases.

Conclusions
the highest probability of reaching 90 years was found for those drinking 5– &lt; 15 g alcohol/day. Although not significant, the risk estimates also indicate to avoid binge drinking.
Fat Grafting to Improve Results of Facelift: Systematic Review of Safety and Effectiveness of Current Treatment Paradigms
Authors: Molina-Burbano Felipe , Smith J Michael , Ingargiola Michael J , Motakef Saba , Sanati Paymon , Lu Jocelyn , Taub Peter J , Hill Michael E 
Published: January 2020

Abstract

Background
Autologous fat grafting is a helpful supplement to facelift surgery that helps to combat age-related volume loss of facial structures. Despite the widespread prevalence of combined facelift and fat-grafting, significant procedural variation exists between providers.

Objectives
The primary purpose of this systematic review was to study the efficacy and complication rates of facelift with lipofilling compared with facelift alone.

Methods
A systematic review of the Cochrane Library and MEDLINE databases as completed was undertaken to identify all clinical reports of fat grafting combined with facelift surgery based on the following key terms: (“fat grafting” OR “lipotransfer” OR “lipofilling” OR “fat transfer”) AND (“facelift” OR “rhytidectomy” OR “SMASectomy” OR “facial rejuvenation”). Data on techniques, outcomes, complications, and patient satisfaction were collected.

Results
The systematic review was performed in April 2017. In total, 248 articles were identified for review. After application of exclusion criteria, 15 primary studies were included in this review. Various facelift techniques were reported, including deep-plane or sub–superficial musculoaponeurotic system (SMAS) facelift, SMAS facelift, modified minimal access cranial suspension lift, component facelift, midface lift, SMAS plication, SMAS-stacking/SMASectomy, and SMASectomy. The most common locations of fat graft injection included the nasolabial folds, tear troughs, temporal regions, midface/cheek/malar eminence, marionette groove, lips, and ear lobes. The addition of fat grafting to facelift surgery resulted in significant improvements in facial volume and aesthetic assessments.

Conclusions
Combined facelift and fat grafting is a safe and efficacious means to simultaneously address age-related ptosis and volume loss. Further research is required to validate and improve existing treatment modalities.

Level of Evidence: 3
LigRMSD: a web server for automatic structure matching and RMSD calculations among identical and similar compounds in protein-ligand docking
Authors: Velázquez-Libera José Luis , Durán-Verdugo Fabio , Valdés-Jiménez Alejandro , Núñez-Vivanco Gabriel , Caballero Julio 
Published: January 2020

Abstract

Motivation
Root mean square deviation (RMSD) is one of the most useful and straightforward features for structural comparison between different conformations of the same molecule. Commonly, protein-ligand docking programs have included some utilities that allow the calculation of this value; however, they only work efficiently when exists a complete atom label equivalence between the evaluated conformations.

Results
We present LigRMSD, a free web-server for the automatic matching and RMSD calculations among identical or similar chemical compounds. This server allows the user to submit only a pair of identical or similar molecules or dataset of similar compounds to compare their three-dimensional conformations.

Availability and implementation
LigRMSD can be freely accessed at https://ligrmsd.appsbio.utalca.cl.

Supplementary information
Supplementary data are available at Bioinformatics online.
Open descending aortic replacement in a patient with a fractured Djumbodis™ dissection system
Authors: Fujikawa Takuya , Chow Simon C Y , Chang Aliss T C , Wong Randolph H L 
Published: January 2020

Abstract
The Djumbodis™ dissection system was introduced as an alternative to aortic arch replacement in acute type A aortic dissection involving the arch. In our own experience, some patients with Djumbodis implantation developed distal aortic arch and descending aortic aneurysm during subsequent follow-up and required additional interventions. However, as there is a high incidence of fracture associated with the Djumbodis system, further endovascular interventions are not feasible. We report a case of successful open descending aortic replacement in a patient with a fractured Djumbodis stent system.
Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults
Authors: Standley Robert A , Distefano Giovanna , Trevino Michelle B , Chen Emily , Narain Niven R , Greenwood Bennett , Kondakci Gramoz , Tolstikov Vladimir V , Kiebish Michael A , Yu Gongxin , Qi Feng , Kelly Daniel P , Vega Rick B , Coen Paul M , Goodpaster Bret H 
Published: January 2020

Abstract

Background
Older adults exposed to periods of inactivity during hospitalization, illness, or injury lose muscle mass and strength. This, in turn, predisposes poor recovery of physical function upon reambulation and represents a significant health risk for older adults. Bed rest (BR) results in altered skeletal muscle fuel metabolism and loss of oxidative capacity that have recently been linked to the muscle atrophy program. Our primary objective was to explore the effects of BR on mitochondrial energetics in muscle from older adults. A secondary objective was to examine the effect of β-hydroxy-β-methylbuturate (HMB) supplementation on mitochondrial energetics.

Methods
We studied 20 older adults before and after a 10-day BR intervention, who consumed a complete oral nutritional supplement (ONS) with HMB (3.0 g/d HMB, n = 11) or without HMB (CON, n = 9). Percutaneous biopsies of the vastus lateralis were obtained to determine mitochondrial respiration and H2O2 emission in permeabilized muscle fibers along with markers of content. RNA sequencing and lipidomics analyses were also conducted.

Results
We found a significant up-regulation of collagen synthesis and down-regulation of ribosome, oxidative metabolism and mitochondrial gene transcripts following BR in the CON group. Alterations to these gene transcripts were significantly blunted in the HMB group. Mitochondrial respiration and markers of content were both reduced and H2O2 emission was elevated in both groups following BR.

Conclusions
In summary, 10 days of BR in older adults causes a significant deterioration in mitochondrial energetics, while transcriptomic profiling revealed that some of these negative effects may be attenuated by an ONS containing HMB.
Factors Associated With Insidious and Noninsidious Disability
Authors: Gill Thomas M , Murphy Terrence E , Gahbauer Evelyne A , Leo-Summers Linda , Han Ling 
Published: January 2020

Abstract

Background
Although disability is often precipitated by an illness/injury, it may arise insidiously. Our objectives were to identify the factors associated with the development of insidious and noninsidious disability and to determine whether these risk factors differ between the two types of disability.

Methods
We prospectively evaluated 754 community-living persons, 70+ years, from 1998 to 2016. The unit of analysis was an 18-month person-interval, with risk factors assessed at the start of each interval. Disability in four activities of daily living and exposure to intervening events, defined as illnesses/injuries leading to hospitalization, emergency department visits, or restricted activity, were assessed each month. Insidious and noninsidious disability were defined based on the absence and presence of an intervening event.

Results
The rate of noninsidious disability (21.7%) was twice that of insidious disability (10.8%). In multivariable recurrent-event Cox analyses, six factors were associated with both disability outcomes: non-Hispanic white race, lower extremity muscle weakness, poor manual dexterity, and (most strongly) frailty, cognitive impairment, and low functional self-efficacy. Three factors were associated with only noninsidious disability (older age, number of chronic conditions, and depressive symptoms), whereas four were associated with only insidious disability (female sex, lives with others, low SPPB score, and upper extremity weakness). The modest differences in risk factors identified for the two outcomes in multivariable analyses were less apparent in the bivariate analyses.

Conclusions
Although arising from different mechanisms, insidious and noninsidious disability share a similar set of risk factors. Interventions to prevent disability should prioritize this shared set of risk factors.
Vertical force scaling in seismic source models of underground nuclear explosions
Authors: Howe Michael , Ekström Göran , Richards Paul G 
Published: January 2020

SUMMARYWe have reanalysed observations of body waves and surface waves for 71 well-recorded underground nuclear explosions (UNEs) that were conducted between 1977 and 1989 at the Balapan subregion of the Semipalatinsk Test Site in Kazakhstan. To reconcile differences between body-wave and surface-wave amplitudes, we solve for a scaling factor between vertical and horizontal forces in the explosion model. We find that the estimated scaling factor is anticorrelated with the scaled depth of burial for the subset of UNEs at Balapan that have published depths. The observed anticorrelation and the inferred variations in force scaling suggest that recorded surface-wave amplitudes are significantly influenced by UNE burial depth as well as by previously recognized tectonic release. As part of our analysis, we revisit the relationship between teleseismic mb(P) and yield for UNEs at Balapan, and discuss the physical basis for effectiveness of the mb–MS discriminant.
Derivation and Internal Validation of a Clinical Prediction Tool to Predict Nonalcoholic Fatty Liver Disease in Patients With Crohn’s Disease
Authors: McHenry Scott , Tirath Ankita , Tsai Richard , Sharma Yeshika , Flores Avegail G , Davidson Nicholas O , Fowler Kathryn J , Ciorba Matthew A , Deepak Parakkal 
Published: January 2020

Abstract

Background
Crohn’s disease (CD) patients have more than double the risk of nonalcoholic fatty liver disease (NAFLD) compared with the general population after considering traditional risk factors. NAFLD remains underappreciated because routine imaging and liver biochemistries are neither sensitive nor specific for the diagnosis. Here we developed a Clinical Prediction Tool for NAFLD in CD (CPN-CD) using readily accessible parameters to diagnose NAFLD, as determined by magnetic resonance proton density fat fraction (PDFF).

Methods
A total of 311 consecutive CD patients who underwent magnetic resonance enterography from June 1, 2017, to May 31, 2018, were screened for NAFLD, defined as a PDFF &gt;5.5% after excluding other liver diagnoses. CPN-CD was derived using binary multivariate logistic regression and internally validated with a 10-fold cross-validation. CPN-CD was compared with the Hepatic Steatosis Index (HSI) by the C-statistic and categorical Net Reclassification Improvement (NRI).

Results
CPN-CD included age, sex, ethnicity/race, serum alanine aminotransferase, body mass index, known cardiometabolic diagnoses, CD duration, and current use of azathioprine/6-mercaptopurine. At &lt;20% risk, NAFLD could be excluded with a sensitivity of 86% (negative predictive value, 86%). At ≥50% risk, NAFLD was diagnosed with a specificity of 87% (positive predictive value, 75%). CPN-CD exhibited good discrimination (C-statistic 0.85) compared with fair discrimination of the HSI (C-statistic, 0.76). CPN-CD was superior to the HSI by net reclassification improvement (+0.20; P &lt; 0.001) and decision curve analysis.

Conclusions
CPN-CD outperforms HSI in detecting NAFLD in patients with CD. Future directions include external validation, outcome validation, and testing generalizability to patients with ulcerative colitis.
A behavioural approach to specifying interventions: what insights can be gained for the reporting and implementation of interventions to reduce antibiotic use in hospitals?
Authors: Duncan Eilidh M , Charani Esmita , Clarkson Janet E , Francis Jill J , Gillies Katie , Grimshaw Jeremy M , Kern Winfried V , Lorencatto Fabiana , Marwick Charis A , McEwen Jo , Möhler Ralph , Morris Andrew M , Ramsay Craig R , Rogers Van Katwyk Susan , Rzewuska Magdalena , Skodvin Brita , Smith Ingrid , Suh Kathryn N , Davey Peter G 
Published: January 2020

AbstractBackgroundReducing unnecessary antibiotic exposure is a key strategy in reducing the development and selection of antibiotic-resistant bacteria. Hospital antimicrobial stewardship (AMS) interventions are inherently complex, often requiring multiple healthcare professionals to change multiple behaviours at multiple timepoints along the care pathway. Inaction can arise when roles and responsibilities are unclear. A behavioural perspective can offer insights to maximize the chances of successful implementation.ObjectivesTo apply a behavioural framework [the Target Action Context Timing Actors (TACTA) framework] to existing evidence about hospital AMS interventions to specify which key behavioural aspects of interventions are detailed.MethodsRandomized controlled trials (RCTs) and interrupted time series (ITS) studies with a focus on reducing unnecessary exposure to antibiotics were identified from the most recent Cochrane review of interventions to improve hospital AMS. The TACTA framework was applied to published intervention reports to assess the extent to which key details were reported about what behaviour should be performed, who is responsible for doing it and when, where, how often and with whom it should be performed.ResultsThe included studies (n = 45; 31 RCTs and 14 ITS studies with 49 outcome measures) reported what should be done, where and to whom. However, key details were missing about who should act (45%) and when (22%). Specification of who should act was missing in 79% of 15 interventions to reduce duration of treatment in continuing-care wards.ConclusionsThe lack of precise specification within AMS interventions limits the generalizability and reproducibility of evidence, hampering efforts to implement AMS interventions in practice.
A Novel Ionic Liquid-Based Liquid-Liquid Microextraction Combined with High Performance Liquid Chromatography for Simultaneous Determination of Eight Vitamin E Isomers in Human Serum
Authors: Yin Shuo , Yang Yi , Zhang Jing , Li Yongxin , Wu Ling , Sun Chengjun 
Published: January 2020

Abstract

Background
Vitamin E deficiencies are prevalent around the world and have become one of the major public health issues. It is necessary to determine their levels in human serum for routine clinical practice.

Objective
In this study, a simple and green ionic liquid-based (IL)vortex-assisted (VA) liquid–liquid microextraction (LLME) combined with HPLC was developed for simultaneous determination of eight vitamin E isomers in human serum.

Methods
The IL, 1-octyl-methylimidazolium trifluoromethanesulfonate ([OMIM]OTf), was added into the diluted sample and vortexed to form a cloudy solution. After centrifugation, the IL phase was collected for HPLC analysis. The separation was accomplished on a Phenomenex Luna-C18 column (250 mm × 4.6 mm, 5 μm) and the column temperature was 30°C. The mobile phase was methanol/acetonitrile (80 + 20, v/v) and the flow rate was 0.7 mL/min. A fluorescence detector was used for the simultaneous detection of eight vitamin E isomers, and the detection wavelength was set at 290/327 nm. The LLME procedure can be completed within 10 min without using any organic solvent. The parameters affecting the extraction efficiencies were optimized, including the type and volume of the ILs, dispersive solvent, vortex time, and salt addition.

Results
Under the optimal conditions, limits of detection were 0.857–4.16 ng/mL. Acceptable recoveries ranging from 80.1% to 103% were achieved, with relative standard deviations less than 13.0%. The proposed method was successfully applied to the detection of eight vitamin E isomers in human serum samples.

Conclusions
This method is simple, fast, environment-friendly, cheap, and has similar linear ranges, sensitivities, accuracy, and precision as those reported chromatographic methods.

Highlights
The IL, [OMIM]OTf, was chosen as the green extractant of LLME for vitamin E extraction because of its strong adsorption property for vitamin E isomers. An IL-VA-LLME method has been developed for the analysis of 8 vitamin E isomers. The established method was successfully applied to the analysis of 8 vitamin E isomers in human serum samples.
Authenticity and the Potability of Coconut Water - a Critical Review
Authors: Burns D Thorburn , Johnston E -L , Walker Michael J 
Published: January 2020

Abstract

Background
The content of the endosperm of the coconut (Cocos nucifera L.) contains “coconut water”. This practically sterile liquid which is prized for its delicate, albeit labile, flavor when fresh, has had a recent dramatic increase in global demand. The organoleptic superiority of water from young coconuts means that degree of maturity at harvesting is the most influential factor in yield and composition.

Objective
To provide a guide to establishing the authenticity and the potability of samples of coconut water.

Method
Review and evaluate the literature on the factors that determine the composition and stability of coconut water.

Results
Data is presented on the variances in natural composition, maturity, processing-induced compositional changes, adulterations, product recalls, classical and instrumental methods of analysis and on the available composition standards of coconut water.

Conclusions
Advice is provided for official food analysts, and others, on prudent approaches as how to ascertain the authenticity and potability, or otherwise, of coconut water samples.
Trap Comparison for Surveillance of the Western Tree Hole Mosquito, Aedes sierrensis (Diptera: Culicidae)
Authors: Chaves Luis Fernando , Reissen Nadja , White Gregory S , Gordon Scott , Faraji Ary 
Published: January 2020

AbstractThe western tree hole mosquito, Aedes sierrensis (Ludlow), is a common nuisance mosquito and vector of Dirofilaria immitis (Leidy), the etiologic agent of dog heartworm, in western North America. Here, we compare weekly mosquito collections made with Mosquito Magnet (MM) traps, Biogents Sentinel (BGS) traps, and Biogents Bowl (BGS Bowl) traps set in Salt Lake City, UT, from the start of June to mid-August 2017. We found the number of mosquitoes decreased with rainfall and temperature independently of trap type. The highest number of mosquitoes were caught by BGS traps baited with carbon dioxide (CO2) and BG lure, which collected 62% (n = 422) of all mosquitoes, followed by the MM at 31% (n = 213), and both the BGS and BG Bowl with BG lure had 3.5% (n = 24) each. Aedes sierrensis females were caught weekly at similar densities (mean ± SD) in BGS with CO2 and lure (1.17 ± 2.93) and the MM (1.17 ± 2.66) traps during the study period. Given that BGS with CO2 and lure traps have several operational advantages over MM traps, including a quicker setup, smaller size, and lower cost, we consider BGS with CO2 and lure traps as the best suited surveillance tool to detect and remove Ae. sierrensis in the western United States and similar settings throughout North America.
Trackers and Trailblazers: Dynamic Interactions and Institutional Design in the Inter-American Court of Human Rights
Authors: Baldini Miranda da Cruz Paula 
Published: January 2020

Abstract
The Inter-American Court’s negative reputation as a judicial activist is often contrasted with its influence in the Inter-American Human Rights System. Despite often issuing broad judgments, the Court has remained a reference and a standard for human rights in the region. This article aims to examine this phenomenon by examining the Court’s institutional powers. The article claims that the Court’s tendency towards judicial activism does not contradict its functions, but rather reflects domestic judicial tendencies and cultures. Domestic judicial cultures and states’ interactions with the Court provide context for the interpretation of its powers and its role in the Inter-American System. The article, therefore, suggests that argumentative legal exchange engaged by the Court and Member States is a healthy way of promoting mutual accountability, while maintaining flexibility for adaptations by both parties and preserving the internal coherence of the regional system.
Evo-physio: on stress responses and the earliest land plants
Authors: Fürst-Jansen Janine M R , de Vries Sophie , de Vries Jan 
Published: January 2020

AbstractEmbryophytes (land plants) can be found in almost any habitat on the Earth’s surface. All of this ecologically diverse embryophytic flora arose from algae through a singular evolutionary event. Traits that were, by their nature, indispensable for the singular conquest of land by plants were those that are key for overcoming terrestrial stressors. Not surprisingly, the biology of land plant cells is shaped by a core signaling network that connects environmental cues, such as stressors, to the appropriate responses—which, thus, modulate growth and physiology. When did this network emerge? Was it already present when plant terrestrialization was in its infancy? A comparative approach between land plants and their algal relatives, the streptophyte algae, allows us to tackle such questions and resolve parts of the biology of the earliest land plants. Exploring the biology of the earliest land plants might shed light on exactly how they overcame the challenges of terrestrialization. Here, we outline the approaches and rationale underlying comparative analyses towards inferring the genetic toolkit for the stress response that aided the earliest land plants in their conquest of land.