bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Specialized Early Care for Alzheimer’s method of caring for people with dementia: an investigation of what works and how
Authors: McCrae Niall , Penhallow Jessica , Rees Olivia , Norman Ian 
Published: December 2019

Background and rationaleSPECAL is a model of care for people with dementia based on a novel conceptualisation of memory and how this changes in dementia. Carers adapt their communication style to prevent distress and promote well‐being for the person with dementia. However, there is limited scientific evidence on the effectiveness of SPECAL.AimThis study explored mechanisms of SPECAL through a qualitative enquiry with family carers.MethodSemi‐structured interviews were conducted with family carers who had been coached in SPECAL and applied its principles and practices. Thematic analysis was applied.FindingsAll participants had found SPECAL helpful in caring for a person with dementia. The core themes of this positive experience were empathy, harmony and resilience. Synthesis of these themes contributes to a proposed model of the mechanisms of SPECAL.ConclusionIn applying SPECAL, carers gained an empathetic insight to the feelings of the person with dementia. This empathy leads to a more harmonious environment, which enhances the carer’s resilience.
Interpreting signals in other people's behavior to sense things about them and to infer things about their world
Authors: Wu Wenjie , Sheppard Elizabeth , Mitchell Peter 
Published: December 2019

AbstractIn this article, we propose a new framework for investigating how accurately and by what process people read others' minds—a process that requires perceivers to make a retrodictive inference. In this context, we discuss the value of a novel methodological approach that complements the conceptual framework. This framework is formulated on the basis of a series of empirical articles emerging over the past few years in which the ideas appear in nascent form. Retrodiction is the process in which, on observing a person's behavior (often but not exclusively a facial expression), people are equipped not only to sense the underlying inner state but also to infer the event that caused that inner state. Indeed, the goal of mindreading need not always be to identify an inner state explicitly but to infer the event that caused the inner state. Doing so is adaptive in that it permits access to a more expansive view of the world through the lens of another mind. This view of mindreading naturally leads to a reconsideration of methods that are fit for purpose and leads to testable hypotheses.
Data-Driven Dynamic Network Modeling for Analyzing the Evolution of Product Competitions
Authors: Xie Jian , Bi Youyi , Sha Zhenghui , Wang Mingxian , Fu Yan , Contractor Noshir , Gong Lin , Chen Wei 
Published: December 2019

Abstract
Understanding the impact of engineering design on product competitions is imperative for product designers to better address customer needs and develop more competitive products. In this paper, we propose a dynamic network-based approach for modeling and analyzing the evolution of product competitions using multi-year buyer survey data. The product co-consideration network, formed based on the likelihood of two products being co-considered from survey data, is treated as a proxy of products’ competition relations in a market. The separate temporal exponential random graph model (STERGM) is employed as the dynamic network modeling technique to model the evolution of network as two separate processes: link formation and link dissolution. We use China’s automotive market as a case study to illustrate the implementation of the proposed approach and the benefits of dynamic network models compared to the static network modeling approach based on an exponential random graph model (ERGM). The results show that since STERGM takes preexisting competition relations into account, it provides a pathway to gain insights into why a product may maintain or lose its competitiveness over time. These driving factors include both product attributes (e.g., fuel consumption) as well as current market structures (e.g., the centralization effect). With the proposed dynamic network-based approach, the insights gained from this paper can help designers better interpret the temporal changes of product competition relations to support product design decisions.
Numerical Simulation of a Steam Injector for Passive Residual Heat Removal
Authors: Schulenberg Thomas , Heinze David 
Published: December 2019

Abstract
In the case of depressurization of a supercritical water-cooled reactor (SCWR), the steam pressure can be used to pump coolant back into the reactor, either by using a turbine driven pump or a steam injector. The latter option is cheaper, more robust, and requires less periodic inspections. The numerical simulation of a steam injector, however, has still been a challenge. In principle, a steam injector consists of a steam nozzle, a mixing chamber, and a diffuser. This paper describes a one-dimensional two-phase flow model simulating the flow and condensation phenomena occurring in the steam nozzle, the structure of shock fronts at the nozzle outlet, the direct contact condensation of steam with cold water in the mixing chamber, and the sudden pressure increase in the final condensation shock front. The model is based only on first principles and on the existing correlations. Correction factors adapting the model to experimental results have not been used yet. For validation, the model has been applied both to separate effect tests and to steam injector tests.
Can a simple ‘cost-awareness’ campaign for laparoscopic hysterectomy change the use and costs of disposable surgical supplies? Pre–post non-controlled study
Authors: Ross Sue , Lier Douglas , Mackinnon Goldie , Bentz Christine , Rakowski Gloria , Capstick Valerie A 
Published: December 2019

ObjectivesDoes a cost-awareness campaign for gynaecologists lead to a change in use and costs of disposable surgical supplies for laparoscopic hysterectomy (LH) without increasing hospital utilisation measures (operating room (OR) time or hospital length of stay (LOS))?DesignPre–post non-controlled study. The OR database was used to identify relevant cases before and after the cost-awareness intervention, and provided information on quantity of each supply item, operative details and LOS.SettingLois Hole Hospital for Women, Edmonton, Alberta, Canada.Participants12 laparoscopic trained gynaecologists (7 female, 5 male) participated in both phases of the study. Eligible surgical cases were all LH cases for any indication for women aged ≥18 years. 201 cases were undertaken before the intervention (2011–2013) and 229 cases after the intervention (2016–2017).InterventionThe cost-awareness intervention for gynaecologists included site meetings and rounds providing information on costs of disposable and reusable instruments, a full day skills lab, OR posters about cost and effectiveness of disposable and reusable surgical supplies and demonstrations of reusable equipment (2015–2016).Primary outcome measureDisposable supplies costs per case (standardised for 2016 unit costs).ResultsThere was a significant (p<0.05) reduction (unadjusted) in disposable supplies cost per case for LH between cases before and after the intervention: from $C1073, SD 281, to $C943 SD 209. Regression analysis found that the adjusted cost per case after the intervention was $C116 lower than before the intervention (95% CI −160 to −71). Neither OR time nor hospital LOS differed significantly between cohorts.ConclusionsOur study suggests that cost-awareness campaigns may be associated with reduction in the cost of surgery for LH. However, many other factors may have contributed to this cost reduction, possibly including other local initiatives to reduce costs and emerging evidence indicating lack of effectiveness of some surgical practices.
Furosemide versus mannitol in Japanese patients with thoracic malignancy who received cisplatin-based chemotherapy using short hydration: study protocol for a randomised controlled trial
Authors: Murakami Eriko , Akamatsu Hiroaki , Shimokawa Toshio , Wada Kiyoko , Yamamoto Nobuyuki 
Published: December 2019

IntroductionCisplatin (CDDP) is a key drug for various thoracic malignancies. To avoid renal toxicity of CDDP, mannitol is routinely used, but it sometimes causes phlebitis which damages patients’ quality of life. Furosemide is another widely used option for diuresis administered more quickly. To date, previous comparisons of these diuretics have lacked statistical significance owing to study design. We therefore undertake a randomised phase II comparative study of furosemide and mannitol in CDDP-based chemotherapy using short hydration.Methods and analysisThis is a two-arm, prospective, randomised, single-centre, open-label phase II study. The primary endpoint is set as the proportion of patients who experienced any grade of ‘creatinine increase’ using the Common Terminology Criteria for Adverse Events V.4.0, during the first cycle. Secondary endpoints are: the proportion of patients who experienced ≥grade 2 of creatinine increase during the first cycle, any grade and ≥grade 2 of creatinine increase after the completion of fourth cycle, and the proportion of patients with phlebitis. Enrolled in this trial will be 105 patients.Ethics and disseminationThis study was approved by the Wakayama Medical University Institutional Review Board on 30 March 2018 study (approval number: 2258). Patients have been enrolled since May 2018. As the study will complete accrual in March 2021, results will be published by 2021. This study will provide important information about the utility of furosemide compared with mannitol to protect against nephrotoxicity.Trial registration numberUMIN000031910.
Cost-effectiveness analysis of pembrolizumab plus chemotherapy for previously untreated metastatic non-small cell lung cancer in the USA
Authors: Zeng Xiaohui , Wan Xiaomin , Peng Liubao , Peng Ye , Ma Fang , Liu Qiao , Tan Chongqing 
Published: December 2019

ObjectivesEvaluating the cost-effectiveness of pembrolizumab plus standard chemotherapy in the first-line setting for patients with metastatic non-small cell lung cancer (NSCLC) from the US payer perspective.DesignA Markov model was constructed to analyse the cost-effectiveness of pembrolizumab plus chemotherapy in the first-line treatment of metastatic NSCLC. Health outcomes were estimated in quality-adjusted life-years (QALYs). The cost information was from Medicare in 2018. One-way and probabilistic sensitivity analyses examined the impact of uncertainty and assumptions on the results.SettingThe US payer perspective.ParticipantsA hypothetical US cohort of patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations.InterventionsPembrolizumab plus chemotherapy versus chemotherapy.Primary outcome measuresCosts, QALYs, incremental cost-effectiveness ratio (ICER) of pembrolizumab plus chemotherapy expressed as cost per QALY gained compared with chemotherapyResultsThe base case analysis demonstrated that pembrolizumab plus chemotherapy provided an additional 0.78 QALYs at incremental cost of $151 409, resulting in an ICER of $194 372/QALY. ICER for pembrolizumab plus chemotherapy was >$149 680/QALY in all of our univariable and probabilistic sensitivity analyses.ConclusionsPembrolizumab in addition to chemotherapy provides modest incremental benefit at high incremental cost per QALY for the treatment of previously untreated metastatic NSCLC.
Secondhand smoke exposure and support for smoke-free policies in cities and rural areas of China from 2009 to 2015: a population-based cohort study (the ITC China Survey)
Authors: Sansone Genevieve , Fong Geoffrey T , Yan Mi , Meng Gang , Craig Lorraine , Xu Steve S , Quah Anne C K , Wu Changbao , Feng Guoze , Jiang Yuan 
Published: December 2019

ObjectivesTo examine trends in smoking prevalence in key venues (workplaces, restaurants, bars) and in public support for comprehensive smoke-free laws, with comparisons between cities and rural areas in China.DesignData are from Waves 3–5 (2009–2015) of the International Tobacco Control (ITC) China Survey, a cohort survey of smokers and non-smokers. Logistic regression analyses employing generalised estimating equations assessed changes in smoking prevalence and support for smoke-free laws over time; specific tests assessed whether partial smoking bans implemented in three cities between Waves 3 and 4 had greater impact.SettingFace-to-face surveys were conducted in seven cities (Beijing, Changsha, Guangzhou, Kunming, Shanghai, Shenyang and Yinchuan) and five rural areas (Changzhi, Huzhou, Tongren, Yichun and Xining).ParticipantsIn each survey location at each wave, a representative sample of approximately 800 smokers and 200 non-smokers (aged 18+) were selected using a multistage cluster sampling design.Main outcome measuresPrevalence of smoking (whether respondents noticed smoking inside restaurants, bars and workplaces); smoking rules inside these venues; and support for complete smoking bans in these venues.ResultsAlthough smoking prevalence decreased and support increased over time, neither trend was greater in cities that implemented partial smoke-free laws. Smoking was higher in rural than urban workplaces (62% vs 44%, p<0.01), but was equally high in all restaurants and bars. There were generally no differences in secondhand smoke (SHS) exposure between smokers and non-smokers except in rural workplaces (74% vs 58%, p<0.05). Support for comprehensive bans was equally high across locations.ConclusionsPartial laws have had no effect on reducing SHS in China. There is an urgent need for comprehensive smoke-free laws to protect the public from exposure to deadly tobacco smoke in both urban and rural areas. The high support among Chinese smokers for such a law demonstrates that public support is not a barrier for action.
Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study
Authors: Hagiya Hideharu , Koyama Toshihiro , Zamami Yoshito , Tatebe Yasuhisa , Funahashi Tomoko , Shinomiya Kazuaki , Kitamura Yoshihisa , Hinotsu Shiro , Sendo Toshiaki , Rakugi Hiromi , Kano Mitsunobu R 
Published: December 2019

ObjectivesFall-related mortality among older adults is a major public health issue, especially for ageing societies. This study aimed to investigate current trends in fall-related mortality in Japan using nationwide population-based data covering 1997–2016.DesignWe analysed fall-related deaths among older persons aged ≥65 years using the data provided by the Japanese Ministry of Health, Labour and Welfare.ResultsThe crude and age-standardised mortality rates were calculated per 100 000 persons by stratifying by age (65–74, 75–84 and ≥85 years) and sex. To identify trend changes, a joinpoint regression model was applied by estimating change points and annual percentage change (APC). The total number of fall-related deaths in Japan increased from 5872 in 1997 to 8030 in 2016, of which 78.8% involved persons aged ≥65 years. The younger population (65–74 years) showed continuous and faster-decreasing trends for both men and women. Average APC among men aged ≥75 years did not decrease. Among middle-aged and older women (75–84 and ≥85 years) decreasing trends were observed. Furthermore, the age-adjusted mortality rate of men was approximately twice that of women, and it showed a faster decrease for women.ConclusionsAlthough Japanese healthcare has shown improvement in preventing fall-related deaths over the last two decades, the crude mortality for those aged over 85 years remains high, indicating difficulty in reducing fall-related deaths in the super-aged population. Further investigations to uncover causal factors for falls in older populations are required.
Association of registered nurse and nursing support staffing with inpatient hospital mortality
Authors: Needleman Jack , Liu Jianfang , Shang Jinjing , Larson Elaine L , Stone Patricia W 
Published: December 2019

BackgroundThe association of nursing staffing with patient outcomes has primarily been studied by comparing high to low staffed hospitals, raising concern other factors may account for observed differences. We examine the association of inpatient mortality with patients’ cumulative exposure to shifts with low registered nurse (RN) staffing, low nursing support staffing and high patient turnover.MethodsCumulative counts of exposure to shifts with low staffing and high patient turnover were used as time-varying covariates in survival analysis of data from a three-campus US academic medical centre for 2007–2012. Staffing below 75% of annual median unit staffing for each staff category and shift type was characterised as low. High patient turnover per day was defined as admissions, discharges and transfers 1 SD above unit annual daily averages.ResultsModels included cumulative counts of patient exposure to shifts with low RN staffing, low nursing support staffing, both concurrently and high patient turnover. The HR for exposure to shifts with low RN staffing only was 1.027 (95% CI 1.002 to 1.053, p<0.001), low nursing support only, 1.030 (95% CI 1.017 to 1.042, p<0.001) and shifts with both low, 1.025 (95% CI 1.008 to 1.043, p=0.035). For a model examining cumulative exposure over the second to fifth days of an admission, the HR for exposure to shifts with low RN staffing only was 1.048 (95% CI 0.998 to 1.100, p=0.061), low nursing support only, 1.032 (95% CI 1.008 to 1.057, p<0.01) and for shifts with both low,1.136 (95% CI 1.089 to 1.185, p<0.001). No relationship was observed for high patient turnover and mortality.ConclusionLow RN and nursing support staffing were associated with increased mortality. The results should encourage hospital leadership to assure both adequate RN and nursing support staffing.
Quantum aspects of Yukawa model with scalar and axial scalar fields in curved spacetime
Authors: Buchbinder Iosif L. , Rodrigues Andreza Rairis , dos Reis Eduardo Antonio , Shapiro Ilya L. 
Published: December 2019

AbstractWe study the Yukawa model with one scalar and one axial scalar fields, coupled to N copies of Dirac fermions, in curved spacetime background. The theory possesses a reach set of coupling constants, including the scalar terms with odd powers of scalar fields in the potential, and constants of non-minimal coupling of the scalar fields to gravity. Using the heat-kernel technique and dimensional regularization, we derive the one-loop divergences, describe the renormalization of the theory under consideration and calculate the full set of beta- and gamma-functions for all coupling constants and fields. As a next step, we construct the renormalized one-loop effective potential of the scalar fields up to the terms linear in scalar curvature. This calculation includes only the contributions from quantum scalar fields, and is performed using covariant cut-off regularization and local momentum representation. Some difficulties of the renormalization group approach to the effective potential in the case under consideration are discussed.
Longitudinal beam dynamics with a higher-harmonic cavity for bunch lengthening
Authors: Bassi Gabriele , Tagger Jüri 
Published: December 2019

We discuss the longitudinal beam dynamics in storage rings in the presence of a higher-harmonic cavity (HHC) system for bunch lengthening. First, we review the general conditions for HHC operations, both in active or passive modes, assuming the stability of the system. For uniform filling patterns, a distinction is made between operations with a normal-conducting HHC, where optimal conditions for bunch lengthening can be satisfied, and operations with a super-conducting HHC, where optimal conditions can be met only approximately. Second, we discuss the option to operate the NSLS-II storage ring with a passive, super-conducting third harmonic cavity (3HC) system. The stability and performance of the system in the presence of a gap in the uniform filling, which corresponds to the present mode of operation of the NSLS-II storage ring, is investigated with self-consistent Vlasov–Fokker–Planck simulations performed with the code SPACE. [G. Bassi, A. Blednykh and V. Smaluk, Phys. Rev. Accel. Beams 19, 024401 (2016).]
Privacy Adversarial Network
Authors: Liu Sicong , Du Junzhao , Shrivastava Anshumali , Zhong Lin 
Published: December 2019

The remarkable success of machine learning has fostered a growing number of cloud-based intelligent services for mobile users. Such a service requires a user to send data, e.g. image, voice and video, to the provider, which presents a serious challenge to user privacy. To address this, prior works either obfuscate the data, e.g. add noise and remove identity information, or send representations extracted from the data, e.g. anonymized features. They struggle to balance between the service utility and data privacy because obfuscated data reduces utility and extracted representation may still reveal sensitive information.
This work departs from prior works in methodology: we leverage adversarial learning to better balance between privacy and utility. We design a representation encoder that generates the feature representations to optimize against the privacy disclosure risk of sensitive information (a measure of privacy) by the privacy adversaries, and concurrently optimize with the task inference accuracy (a measure of utility) by the utility discriminator. The result is the privacy adversarial network (PAN), a novel deep model with the new training algorithm, that can automatically learn representations from the raw data. And the trained encoder can be deployed on the user side to generate representations that satisfy the task-defined utility requirements and the user-specified/agnostic privacy budgets.
Intuitively, PAN adversarially forces the extracted representations to only convey information required by the target task. Surprisingly, this constitutes an implicit regularization that actually improves task accuracy. As a result, PAN achieves better utility and better privacy at the same time! We report extensive experiments on six popular datasets, and demonstrate the superiority of PAN compared with alternative methods reported in prior work.