bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARATIVE EVALUATION OF ANTIMICROBIAL SUSCEPTIBILITY PATTERN AND VIRULENCE FACTORS AMONG ESBL AND NONESBL PRODUCING ESCHERICHIA COLI
Authors: Shenoy Shilpa , K. Sumathi , Shetty A. Veena 
Published: June 2020

AbstractObjectives: The present study was carried out to compare the antimicrobial susceptibility pattern and phenotypic characteristics in ESBL and non-ESBL producing clinically isolated E.coli.
Material and Methods: A total of 100 non-duplicate consecutive isolates of E.coli were collected from various clinical specimens obtained from K.S. Hegde Charitable Hospital, Mangalore. All the isolates were studied for antimicrobial susceptibility pattern using modified Kirby-Bauer method. ESBL production was screened phenotypically by an initial screening test, which was followed by confirmatory Double disk synergy test. These isolates were screened for virulence factors such as Biofilm assay, hemolysin production and Congo red agar to detect the invasiveness of the isolates.
Results: Out of the 100 E.coli isolates, 45(45%) isolates exhibited ESBL production. Among the ESBL producing isolates 62% were haemolytic, 77% exhibited Congo red uptake, and these two factors were statistically significant as compare non ESBL producing isolates, while 47%, 35% and 18% of the isolates exhibited high, moderate and low biofilm forming ability, respectively. The ESBL producing isolates were multi-drug resistant. There was statistical significance among the ESBL production and expression of virulence factors
Conclusion: The present investigation revealed, a high prevalence of multiple virulence factors among the ESBL in addition to multidrug resistance when compared with non - ESBL isolates. This indicates a dire need for effective ESBL surveillance and control in the hospitals and judicious use of antibiotics among the general public.
A DESCRIPTIVE STUDY TO ASSESS THE KNOWLEDGE ON BREAST CANCER AND UTILIZATION OF MAMMOGRAM AMONG WOMEN IN SELECTED VILLAGES OF UDUPI DISTRICT, KARNATAKA
Authors: Shadap Arkierupaia , Pais Maria , Prabhu Anusuya 
Published: June 2020

AbstractBreast cancer was considered to be one amongst the most commonly cancer disease in the world. Now it is considered to be the second cancer disease among women in India, with most of the affected population is in the urban areas. Breast cancer is seen mostly after the age of 40 years. According to the Cancer fact 2012, breast cancer is now seen to be among women aged from 35 years above.
Materials and methods: The study was a descriptive survey study to assess the knowledge on breast cancer, awareness and utilization of mammogram among 320 married and unmarried women who were willing to participate in the study. After the consent, a questionnaire prepared by the investigator was given to them.
Results: Majority 46.6% had low knowledge for breast cancer. There was an association between knowledge and age, marital status, education and source of information about breast cancer and it was found to be significant (p< Mammogram is underutilized among participants, from the total number of population i.e; n = 320, only 19.1% (61) were aware of mammogram. Out of 19.1% (61) who were aware of mammogram, did not utilise it.
Conclusion: The study concluded that women have low knowledge on breast cancer and very less population was aware of mammogram which is one of the screening tests for breast cancer. Their low knowledge on breast cancer and unaware of the screening test is the main reason for not utilising mammogram even those who are aware of it. So, nurses as health care members play an important role in providing information and educating the community people.
A STUDY ON KNOWLEDGE OF PRIMI MOTHERS ON SELF MANAGEMENT OF MINOR DISCOMFORTS OF PREGNANCY
Authors: Vincent Sharon , Nayak Sabitha , Paul Shiney 
Published: June 2020

Abstract'A study on knowledge of primi mothers on self-management of minor discomfort of pregnancy with a view to develop information' was carried out in Justice K.S Hegde Charitable hospital on 100 primi-gravida mothers by using purposive sampling technique. The findings of the study showed that 87% of the primi mothers were in the age group of 21-30 years, 37% of the women had high school education, 70% of the subjects were Hindus, 77% belonged to joint families and 53% were in the gestational age group of 29-40 weeks.Most 59% of the Primigravida mothers had poor knowledge, 29% had average knowledge, and 12% had good knowledge regarding minor discomforts of pregnancy and its self-management.Area wise knowledge of Primigravida mothers reveals deficiency in most of the areas, but the lowest mean percentage of score is 28.25% with a standard deviation of 1.74 in the area of knowledge related to Circulatory and Nervous system, which indicated that the maximum knowledge deficit is in this area.There was significant association between knowledge of Primigravida mothers and age, educational qualification. The calculated ?2 values were 3.953 and 12.603 respectively which are more than the table value 3.84 and 7.82 at 0.05% level of significance. Hence, the research hypothesis was accepted.The result of the study proved that Primigravida mothers had poor knowledge regarding minor discomforts of pregnancy and its selfmanagement. The findings of the study showed that there was a need to educate all women on preparation towards motherhood. Providing an information booklet on minor discomforts of pregnancy and its management, an uneventful antenatal period can be expected from the mother.
How Do the Locking Screws Lock? A Micro-CT Study of 3.5-mm Locking Screw Mechanism
Authors: Kaczmarek Jakub , Bartkowiak Tomasz , Paczos Piotr , Gapinski Bartosz , Jader Hanna , Unger Martin 
Published: June 2020

Abstract
Objective To quantify the amount of the screw head thread and the plate hole thread connection in two 3.5 mm locking plates: Locking Compression Plate (LCP) and Polyaxial Locking System (PLS).
Materials and Methods A micro - CT scan of a screw head - plate hole connection was performed pre- and post destructive tests. Tests were performed on bone surrogates in a fracture gap model. The 3.5 LCP and 3.5 PLS plates, with 3 perpendicular screws per segment were used in a destructive static test. The 3.5 PLS plates with mono- and polyaxial screws were compared in a cyclic fatigue tests in two orthogonal directions. Pre - and post - test scan datasets were compared. Each dataset was converted into serial images depicting sections cut orthogonally to locking screw axis. The amount of engagement was detected through automated image postprocessing.
Results The mean amount of the thread connection for the LCP was 28.85% before and 18.55% after destructive static test. The mean amount of the connection for the PLS was 16.20% before and 14.55% after destructive static test. When inserted monoaxially, the mean amount of the connection for the PLS screws was 14.4% before and 19.24% after destructive cyclic test. The mean amount of the connection for the polyaxial inserted PLS screws when loaded against plate thickness was 2.99% before and 2.08% after destructive cyclic test. The mean amount of the connection for the polyaxial inserted PLS screws when loaded against plate width was 3.36% before and 3.93% after destructive cyclic test. The 3D visualization of the thread connection showed that the initial interface points between screw head and plate hole are different for both LCP and PLS after the destructive testing. Depending on the type of applied force, there was either loss or increase of the contact.
Clinical Relevance Micro-CT offers news possibilities in locking implant investigation. It might be helpful in better understanding the nature of locking mechanism and prediction of possible mode of failure in different systems.
Long-Term Radiologic Evaluation of Microaspirations among Patients after Esophagectomy
Authors: Pines Guy , Jacobson Francine , Zheng Yifan , Magali Pham , Lerut Toni , Bueno Raphael 
Published: June 2020

Abstract
Objectives Aspirations are common after esophagectomy. Data are lacking regarding its long-term radiological manifestations. The purpose of this study is to determine the incidence and radiological patterns of aspirations among long-term survivors and evaluate their clinical significance.
Methods The records of all patients who underwent esophagectomy between October 2003 and December 2011 and survived more than 3 years were reviewed. Preoperative, first routine postoperative, and latest chest computed tomography (CT)scans were reviewed. Imaging studies were reviewed for radiological signs suspicious of aspirations, conduit location, anastomotic site, and maximal intrathoracic diameter. Data regarding patients' complaints during clinic visits were also collected.
Results A total of 578 patients underwent esophagectomy during the study period. One-hundred twenty patients met the inclusion criteria. Median follow-up was 83.5 months. Cervical and intrathoracic anastomoses were performed in 103 and 17 patients, respectively. A higher rate of CT findings was found in postoperative imaging (n = 51 [42.5%] vs. n = 13 [10.8%] respectively, p < 0.05). Most of these were found in the lower lobes (61%). A higher rate of lesions was found among patients in whom the conduit was bulging to the right hemithorax compared with totally mediastinal or completely in the right hemithorax (54.5 vs. 35.2% and 34.6%, respectively, p < 0.05). No correlation was found with conduit diameter or anastomotic site. These lesions were more prevalent among patients who complained of reflux or cough during meals (NS).
Conclusions A significantly higher rate of new CT findings was found in postoperative imaging of this post-esophagectomy cohort, suggesting a high incidence of aspirations. The locations of the conduit, rather than anastomosis site, seem to play a role in the development of these findings. Further research is needed to evaluate the clinical significance of these findings.
Periprocedural Direct Oral Anticoagulant Management: The RA-ACOD Prospective, Multicenter Real-World Registry
Authors: Ferrandis Raquel , Llau Juan V. , Sanz Javier F. , Cassinello Concepción M. , González-Larrocha Óscar , Matoses Salomé M. , Suárez Vanessa , Guilabert Patricia , Torres Luís-Miguel , Fernández-Bañuls Esperanza , García-Cebrián Consuelo , Sierra Pilar , Barquero Marta , Montón Nuria , Martínez-Escribano Cristina , Llácer Manuel , Gómez-Luque Aurelio , Martín Julia , Hidalgo Francisco , Yanes Gabriel , Rodríguez Rubén , Castaño Beatriz , Duro Elena , Tapia Blanca , Pérez Antoni , Villanueva Ángeles M. , Álvarez Juan-Carlos , Sabaté Sergi ,   for the RA-ACOD investigators
Published: June 2020

Abstract
Introduction There is scarce real-world experience regarding direct oral anticoagulants (DOACs) perioperative management. No study before has linked bridging therapy or DOAC-free time (pre-plus postoperative time without DOAC) with outcome. The aim of this study was to investigate real-world management and outcomes.
Methods RA-ACOD is a prospective, observational, multicenter registry of adult patients on DOAC treatment requiring surgery. Primary outcomes were thrombotic and hemorrhagic complications. Follow-up was immediate postoperative (24–48 hours) and 30 days. Statistics were performed using a univariate and multivariate analysis. Data are presented as odds ratios (ORs [95% confidence interval]).
Results From 26 Spanish hospitals, 901 patients were analyzed (53.5% major surgeries): 322 on apixaban, 304 on rivaroxaban, 267 on dabigatran, 8 on edoxaban. Fourteen (1.6%) patients suffered a thrombotic event, related to preoperative DOAC withdrawal (OR: 1.57 [1.03–2.4]) and DOAC-free time longer than 6 days (OR: 5.42 [1.18–26]). Minor bleeding events were described in 76 (8.4%) patients, with higher incidence for dabigatran (12.7%) versus other DOACs (6.6%). Major bleeding events occurred in 17 (1.9%) patients. Bridging therapy was used in 315 (35%) patients. It was associated with minor (OR: 2.57 [1.3–5.07]) and major (OR: 4.2 [1.4–12.3]) bleeding events, without decreasing thrombotic events.
Conclusion This study offers real-world data on perioperative DOAC management and outcomes in a large prospective sample size to date with a high percentage of major surgery. Short-term preprocedural DOAC interruption depending on the drug, hemorrhagic risk, and renal function, without bridging therapy and a reduced DOAC-free time, seems the safest practice.
Cardiac Sarcoidosis
Authors: Birnie David H. 
Published: June 2020

AbstractApproximately 5% of patients with sarcoidosis will have clinically manifest cardiac involvement presenting with one or more of ventricular arrhythmias, conduction abnormalities, and heart failure. It is estimated that another 20 to 25% of pulmonary/systemic sarcoidosis patients have asymptomatic cardiac involvement (clinically silent disease). Cardiac presentations can be the first (and/or an unrecognized) manifestation of sarcoidosis in a variety of circumstances. Immunosuppression therapy (usually with corticosteroids) has been suggested for the treatment of clinically manifest cardiac sarcoidosis (CS) despite minimal data supporting it. Positron emission tomography imaging is often used to detect active disease and guide immunosuppression. Patients with clinically manifest disease often need device therapy, typically with implantable cardioverter defibrillators (ICDs). The extent of left ventricular dysfunction seems to be the most important predictor of prognosis among patients with clinically manifest CS. In the current era of earlier diagnosis, modern heart failure treatment, and use of ICD therapy, the prognosis from CS is much improved. In a recent Finnish nationwide study, 10-year cardiac survival was 92.5% in 102 patients.
Cutaneous Sarcoidosis
Authors: Caplan Avrom , Rosenbach Misha , Imadojemu Sotonye 
Published: June 2020

AbstractSarcoidosis is a chronic, multisystem, inflammatory disorder of unknown etiology that is characterized by noncaseating granulomas that impair normal organ functioning. Sarcoidosis predominantly affects the lungs, but the skin is often cited as the second most frequently involved organ. Cutaneous manifestations of sarcoidosis are highly variable and ongoing research seeks to better understand the relationship between clinical morphology and disease prognosis. Skin findings in patients with sarcoidosis can be “specific,” in which sarcoidal granulomas infiltrate the skin, or they can represent a “nonspecific” reactive inflammatory process, as is seen in calcinosis cutis and erythema nodosum. Cutaneous sarcoidosis can be the initial presenting sign or develop later in the course of the disease. In some patients, the skin will be the most involved and impactful organ system and will drive therapy. In other cases, the skin will be an incidental or minor finding, but may be easily accessible for biopsy to confirm the diagnosis. There are many potential therapies for sarcoidosis, though no one therapy is universally effective.
The Importance of the Occlusal Plane in Predicting Better Facial Soft Tissue in Class II Malocclusion in Ethnic Javanese
Authors: Ardani I. Gusti Aju Wahju , Dinata Floretta Charlene , Triwardhani Ari 
Published: June 2020

Abstract
Objectives Class II malocclusion is largely due to a retrognathic mandible. Mandibular rotation is closely related to changes in the occlusal plane during growth. The problems in the occlusal plane could cause disadvantages in the soft tissue profile in Class II malocclusion, presenting treatment challenges for an orthodontist. This study aimed to investigate the importance of the occlusal plane for a better soft tissue profile in Class II malocclusion for Javanese patients.
Materials and Methods The total number of cephalogram softcopies of patients with skeletal Class II malocclusion were selected based on ANB values (> 4 degrees), no agenesis teeth except the third molar, and all permanent teeth. The cephalograms were calculated using digital tracing by Morpheus 3D imaging. The points and areas to be analyzed on the cephalogram were predetermined. The examination was performed in a span of 1 month and performed via a statistical test using Pearson’s test and multiple regression analysis (p < 0.05).
Results There were significant correlation values between the angles produced by the occlusal plane to sella national, Frankfurt horizontal, mandibular plane, and Z-angle (p < 0.05).
Conclusion Patients with skeletal Class II malocclusion have a significant correlation between the occlusal plane and the vertical plane, thereby affecting the shape of the soft tissue profile, which causes a facial imbalance. By improving mandibular movement, the soft tissue profile can also be corrected.
Health-Related Quality of Life and Psychosocial Morbidity in Anorectal Malformation and Hirschsprung's Disease
Authors: Feng Xiaoyan , Lacher Martin , Quitmann Julia , Witt Stefanie , Witvliet Marieke J. , Mayer Steffi 
Published: June 2020

AbstractAnorectal malformation (ARM) and Hirschsprung's disease (HD) are the most common congenital colorectal anomalies. Despite advances in surgical techniques and improvements in postoperative clinical care, short- and long-term physical and psychosocial morbidity of these patients remains high. This review outlines the current literature on the physical and psychosocial aspects of health-related quality of life (HrQoL) and its confounders in patients with ARM/HD. Moreover, important coping strategies are summarized to further improve HrQoL of ARM/HD patients and their families.
Cardiac Surgery 2019 Reviewed
Authors: Doenst Torsten , Bargenda Steffen , Kirov Hristo , Moschovas Alexandros , Tkebuchava Sophie , Safarov Rauf , Velichkov Ilia , Diab Mahmoud 
Published: June 2020

AbstractFor the year 2019, almost 25,000 published references can be found in PubMed when entering the search term “cardiac surgery.” We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach for article selection and reviewed the main fields of adult cardiac surgery (i.e., coronary, valve, aortic, and heart failure surgery). The past decade has experienced an enormous development of interventional techniques that compete more and more with classic surgery. This contest was broadly visible in 2019. It peaked over the interpretation of the EXCEL trial data, where percutaneous coronary intervention and coronary artery bypass grafting (CABG) for left main disease were compared. A novel pathomechanism for CABG was proposed, potentially answering open questions in the field. In aortic valve surgery, two low-risk trials comparing transcatheter aortic valve implantation (TAVI) to classic aortic valve replacement (surgical aortic valve replacement) received attention for showing equal or superior short-term outcomes for TAVI. Longer follow-up information from recent trials became available presenting results emphasizing the need for joint decision making. While publications addressing surgery on the aorta and the mitral and tricuspid valves were less abundant, there was substantial activity regarding left ventricular assist device support and heart transplantation. This article attempts to summarize the most pertinent publications. It does not expect to be complete and cannot be free of individual interpretation. We aimed to provide a condensed summary of 2019s publications with a stimulus for in-depth reading and a basis supporting patient information.
Distribution of Cytokeratin 17 in the Parenchymal Elements of Rat’s Submandibular Glands Subjected to Fractionated Radiotherapy
Authors: Hassan Sherif S. , Attia Mahmoud A. , Attia Alaa M. , Nofal Reda A. , Fathi Adel 
Published: June 2020

Abstract
Objectives The aim of this research was to study the intensity of cytokeratin 17 (CK17) in the parenchymal elements of rat’s submandibular salivary glands subjected to fractionated radiotherapy regimen that used for treatment of head and neck malignancy.
Materials and Methods Twenty male albino rats were divided into two equal groups (normal and irradiated). The irradiated group received a radiation dose of 5 Grays daily for 5 days using therapeutic X-ray beam. Six months later, submandibular gland was dissected out and prepared for both histological and immunohistochemical studies.
Results Submandibular gland of irradiated group showed two different types of histological alterations. The first alteration showed severe gland atrophy replaced by either fibrous or fatty tissues. In some sections, the gland exhibited proliferating activity in the form of profuse amounts of mitotic figures. Immunohistochemical examination of control glands displayed a mild cytoplasmic expression of CK17 of duct cells as well as serous acini. The staining pattern was either diffused or concentrated at the basal part of the cell with negative expression at its apical part.
Statistical Analysis Expression of CK17 in submandibular gland of irradiated group displayed a highly significant differences (P < 0.001) in both intercalated and striated ducts. Many serous acini displayed a highly significant differences (P < 0.001) whereas, mucous acini were negatively stained.
Conclusions The intensity and diffusion of CK17 expression in our results foretell the pathological effect of radiotherapy on the intermediate filaments of salivary gland parenchyma that interfered with production and/or secretion of saliva leading to xerostomia.
Krylov–Bogolyubov averaging
Authors: Jian W. , Kuksin S. B. , Wu Y. 
Published: June 2020

Abstract
A modified approach to the classical Krylov– Bogolyubov averaging method is presented. It was developed recently for studying partial differential equations, enables one to treat Lipschitz perturbations of linear systems with purely imaginary spectrum, and may be generalized to the case of systems of PDEs with small non-linearities.
Bibliography: 10 titles.
Motion-flow-guided recurrent network for respiratory signal estimation of x-ray angiographic image sequences
Authors: Fang Huihui , Li Heng , Song Shuang , Pang Kun , Ai Danni , Fan Jingfan , Song Hong , Yu Yang , Yang Jian 
Published: June 2020

Abstract
Motion compensation can eliminate inconsistencies of respiratory movement during image acquisitions for precise vascular reconstruction in the clinical diagnosis of vascular disease from x-ray angiographic image sequences. In x-ray-based vascular interventional therapy, motion modeling can simulate the process of organ deformation driven by motion signals to display a dynamic organ on angiograms without contrast agent injection. Automatic respiratory signal estimation from x-ray angiographic image sequences is essential for motion compensation and modeling. The effects of respiratory motion, cardiac impulses, and tremors on structures in the chest and abdomen bring difficulty in extracting accurate respiratory signals individually. In this study, an end-to-end deep learning framework based on a motion-flow-guided recurrent network is proposed to address the aforementioned problem. The proposed method utilizes a convolutional neural network to learn the spatial features of every single frame, and a recurrent neural network to learn the temporal features of the entire sequence. The combination of the two networks can effectively analyze the image sequence to realize respiratory signal estimation. In addition, the motion-flow between consecutive frames is introduced to provide a dynamic constraint of spatial features, which enables the recurrent network to learn better temporal features from dynamic spatial features than from static spatial features. We demonstrate the advantages of our approach on designed datasets which contain coronary and hepatic angiographic sequences with diaphragm structures, and coronary angiographic sequences without diaphragm structures. Our method improves over state-of-the-art manifold-learning-based methods by 85.7%, 81.5% and 75.3% in respiratory signal accuracy metric on these datasets. The results demonstrate that the proposed method can effectively estimate respiratory signals from multiple motion patterns.