bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons
Authors: van Tol Alexander F. , Roschger A. , Repp F. , Chen J. , Roschger P. , Berzlanovich A. , Gruber G. M. , Fratzl P. , Weinkamer Richard 
Published: November 2019

AbstractA popular hypothesis explains the mechanosensitivity of bone due to osteocytes sensing the load-induced flow of interstitial fluid squeezed through the lacunocanalicular network (LCN). However, the way in which the intricate structure of the LCN influences fluid flow through the network is largely unexplored. We therefore aimed to quantify fluid flow through real LCNs from human osteons using a combination of experimental and computational techniques. Bone samples were stained with rhodamine to image the LCN with 3D confocal microscopy. Image analysis was then performed to convert image stacks into mathematical network structures, in order to estimate the intrinsic permeability of the osteons as well as the load-induced fluid flow using hydraulic circuit theory. Fluid flow was studied in both ordinary osteons with a rather homogeneous LCN as well as a frequent subtype of osteons—so-called osteon-in-osteons—which are characterized by a ring-like zone of low network connectivity between the inner and the outer parts of these osteons. We analyzed 8 ordinary osteons and 9 osteon-in-osteons from the femur midshaft of a 57-year-old woman without any known disease. While the intrinsic permeability was 2.7 times smaller in osteon-in-osteons compared to ordinary osteons, the load-induced fluid velocity was 2.3 times higher. This increased fluid velocity in osteon-in-osteons can be explained by the longer path length, needed to cross the osteon from the cement line to the Haversian canal, including more fluid-filled lacunae and canaliculi. This explanation was corroborated by the observation that a purely structural parameter—the mean path length to the Haversian canal—is an excellent predictor for the average fluid flow velocity. We conclude that osteon-in-osteons may be particularly significant contributors to the mechanosensitivity of cortical bone, due to the higher fluid flow in this type of osteons.
Secondary Traumatic Stress in Foster Carers: Risk Factors and Implications for Intervention
Authors: Bridger Kay M. , Binder Jens F. , Kellezi Blerina 
Published: November 2019

Abstract
Objectives
Fostering, a professional or semi-professional role that is in increasing demand, involves potential exposure to material related to children’s trauma in a domestic setting. Yet, professional vulnerability to secondary traumatic stress (STS) is under-researched in foster carers, as is the suitability of associated intervention techniques. We therefore investigated incidence of STS and psychological predictors relevant to secondary and primary stress appraisal in UK foster carers.

Methods
British foster carers (n = 187; 81% female; aged 23–72 years; mean length of experience 9 years) were approached through a range of organizations managing paid foster caring in the UK for a survey study. Self-report measures were obtained on STS, burnout and compassion satisfaction from the Professional Quality of Life (ProQOL) scale, as well as on primary trauma and variables previously recommended for inclusion in training targeting secondary trauma: empathy, resilience and self-care.

Results
High levels of STS and burnout were found among foster carers. In multivariate model testing, STS was directly and positively predicted by burnout, compassion satisfaction and primary trauma (R2 = 0.54, p < 0.001). Resilience, empathy and self-care did not show direct associations with STS, but self-care had a significant indirect effect on STS.

Conclusions
Findings support the view that STS is a substantial risk factor in foster caring. While self-care is confirmed as a promising factor in intervention, the roles of empathy and resilience are more ambiguous.
Effects of Vocational Re-training on Employment Outcomes Among Persons with Disabilities in Germany: A Quasi-Experiment
Authors: Echarti Nicolas , Schüring Esther , O’Donoghue Cathal 
Published: November 2019

AbstractPurpose To investigate how completing vocational re-training influenced income and employment days of working-age people with disabilities in the first 8 years after program admission. The investigation also included the influence of vocational re-training on the likelihood of receiving an earnings incapacity pension and on social security benefit receipt. Methods This retrospective cohort study with 8 years follow up was based on data from 2399 individuals who had completed either a 1-year vocational re-training program (n = 278), or a 2-year vocational re-training program (n = 1754) or who were admitted into re-training but never completed the program (n = 367). A propensity score-based method was used to account for observed differences and establish comparability between program graduates and program dropouts. Changes in outcomes were examined using the inverse probability-weighted regression adjustment method. Results After controlling for other factors, over the 8 years after program admission, graduates of 1-year re-training, on average, were employed for an additional 405 days, 95% CI [249 days, 561 days], and had earned €24,260 more than without completed re-training, 95% CI [€12,805, €35,715]. Two-year program completers, on average, were employed for 441 additional days, 95% CI [349 days, 534 days], and had earned €35,972 more than without completed re-training, 95% CI [€27,743, €44,202]. The programs also significantly reduced the number of days on social-security and unemployment benefits and lowered the likelihood of an earnings incapacity pension. Conclusion Policies to promote the labor market re-integration of persons with disabilities should consider that vocational re-training may be an effective tool for sustainably improving work participation outcomes.
Fascination du simulacre
Authors: Gergye László 
Published: November 2019

RésuméPar l’analyse de l’œuvre d’Andersen intitulée Skyggen, cet article cherche à illustrer la transformation radicale des éléments de technique narrative des contes au sens traditionnel et du Bildungsroman. Sur l’analogie des récits type Doppelgänger du romantisme allemand, ce n’est pas que le rapport differencié de l’original et de la copie qui se dégage dans cette histoire, mais l’auteur fait aussi un tableau précis du remodelage des principles essentiels de l’esthétique romantique de la poésie. L’ancien idéal de la kalokagathia qui dérive de l’Antiquité s’anéantit, la trichotomie conceptuelle du beau, du bon et du vrai se désintègre et se voit remplacer par une attirance évidente au démoniaque, au subconscient et à l’amoral dans la pratique « artistique » de l’Ombre. À travers la créativité de la copie devenue indépendante, l’écriture, qui s’avère complètement inefficace dans la main du Savant, se renforce pour devenir un véritable facteur social—par la genre catalyseur du commérage—, faisant ainsi un pied de nez à la culture romantique fondamentalament basée sur l’oralité.
Branding higher education: an exploration of the role of internal branding on middle management in a university rebrand
Authors: Clark Paul , Chapleo Chris , Suomi Kati 
Published: November 2019

AbstractAlthough research on branding in higher education has grown, a specific focus on internal branding in this sector is still scarce. Brand support by mid-level administrative staff and deans is a key element in internal branding of a university. This study explores the extent to which internal branding contributes to this group’s understanding of and engagement with a public institution’s rebranding campaign. It identifies challenges and practice insights for practice for internal branding activities when engaging these internal stakeholders, linking to wider brand management theory and practice. A qualitative case study approach was employed to understand the effectiveness of internal branding holistically, and in context. In 2016, nineteen depth interviews were conducted with a range of mid-level administrators and deans including those at the student union, regional campuses, directors of departments, and deans of faculties and schools at a large Canadian university. The data was analysed using Nvivo qualitative data analysis software. On the basis of the results, it is apparent that internal branding has a valuable role in relation to higher education brand management strategy. Results offer a holistic view of the rebranding process, and explore understanding of and engagement with the rebranding campaign. This paper addresses a gap in the public sector brand management literature and demonstrates theoretical and practical implications for improved understanding and brand management strategy.
Policy Monitoring in the EU: The Impact of Institutions, Implementation, and Quality
Authors: Schoenefeld Jonas J. , Schulze Kai , Hildén Mikael , Jordan Andrew J. 
Published: November 2019

AbstractPolicy monitoring is often seen as a crucial ingredient of policy evaluation, but theoretically informed empirical analyses of real-world policy monitoring practices are still rare. This paper addresses this gap by focusing on climate policy monitoring in the European Union, which has a relatively stringent system of greenhouse gas monitoring but a much less demanding approach to monitoring policies. It explores how institutional settings, policy implementation, and the quality of information may impact the practices and politics of policy monitoring. Drawing on quantitative regression models and qualitative interviews, it demonstrates that policy monitoring has evolved over time and is itself subject to implementation pressures, but also exhibits learning effects that improve its quality. In further developing both everyday policy monitoring practices and academic understanding of them, there is a need to pay attention to their design—specifically, the impact of any overarching rules, the institutional support for implementation, and the criteria governing the quality of the information they deliver. In short, policy monitoring should be treated as a governance activity in its own right, raising many different design challenges.
Dynamic capabilities triggered by cloud sourcing: a stage-based model of business model innovation
Authors: Muhic Mirella , Bengtsson Lars 
Published: November 2019

AbstractCurrent research offers very limited insights on the process of how the adoption and continued use of cloud sourcing might trigger and push the development of business model innovation and affect the competitive advantage of a firm. Applying an abductive approach, with two longitudinal case studies of cloud sourcing firms, and a theoretical framework based on stage-based models of business model innovation and the dynamic capability view of the firm, we develop a model of stage-based business model innovation related to the adoption and continued use of cloud sourcing. The model identifies three business model innovation stages characterized by specific types of capabilities. In between the three stages, we identify three dynamic junctures that the firm and its managers have to overcome to progress from one stage to another. In the dynamic junctures three types of dynamic capabilities were key; sensing, seizing and transformation capabilities, to pass to the next stage. The model contributes to a better understanding of the evolution of dynamic capabilities as well as the evolution of the cloud sourcing firm and cloud-based business model innovation.
‘Even though I Am Blind, I Am Still Human!’: the Neglect of Adolescents with Disabilities’ Human Rights in Conflict-Affected Contexts
Authors: Presler-Marshall Elizabeth , Jones Nicola , Odeh Kifah Bani 
Published: November 2019

AbstractDrawing on qualitative research undertaken with adolescents with disabilities from refugee and host communities in Jordan and the State of Palestine, this article critically interrogates the framing of child neglect, which to date has situated the state as a protector rather than a perpetrator, the narrow understanding of adolescent needs and the responsibility of international actors for ensuring that the full range of human rights of adolescents with disabilities is supported. We frame our findings on adolescent neglect through a multidimensional capabilities lens and argue that although both adolescence as a distinct lifecycle stage and the rights of persons with disabilities have moved up the development agenda, adolescents with disabilities remain largely invisible, and especially so in conflict-affected contexts. Our findings highlight that adolescents with disabilities have limited access to schooling, skills building for economic empowerment and healthcare, due to accessibility challenges, cost and highly limited specialist provisioning. Moreover, adolescents with disabilities also have very little access to psychosocial support or opportunities to develop the independence which is a hallmark of adolescence and critical for successful transitions into early adulthood. Rather than working to meet those needs, the government and UN agencies tasked with provisioning in conflict-affected areas continue to miss opportunities to link young people with disabilities to existent services and tend to rely on NGOs to deliver small-scale, time-bound programming rather than assuming responsibility for appropriate programming at scale.
Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes
Authors: Głombik Katarzyna , Detka Jan , Góralska Joanna , Kurek Anna , Solnica Bogdan , Budziszewska Bogusława 
Published: November 2019

AbstractCurrent data suggest an important role of brain metabolic disturbances in the pathogenesis of depression and obesity, diseases that frequently co-occur. Our aim was to determine whether there are changes in markers characterizing glucose metabolism in prenatal stress (PS; animal model of depression), in rats fed a high-fat diet (HFD), and especially in the model of depression and obesity co-occurrence. The changes in glucose-6-phosphate, glycogen, glucose transporters (GLUT1, GLUT4), glucagon-like peptide-1 receptor (GLP-1R), and mitochondrial complexes levels in the frontal cortex and/or hippocampus were observed. In the case of the coexistence of depression and obesity, the most important changes were (1) the decrease in the membrane form of GLUT4, which may suggest weaker insulin action in the frontal cortex, and (2) the diminished GLP-1R, which could cause neurodegenerative changes in the hippocampus. However, presented results suggested that HFD weakened the PS effect of uncoupling oxidative phosphorylation in the frontal cortex.
Adaptive aiding with an individualized workload model based on psychophysiological measures
Authors: Teo Grace , Matthews Gerald , Reinerman-Jones Lauren , Barber Daniel 
Published: November 2019

AbstractPotential benefits of technology such as automation are oftentimes negated by improper use and application. Adaptive systems provide a means to calibrate the use of technological aids to the operator’s state, such as workload state, which can change throughout the course of a task. Such systems require a workload model which detects workload and specifies the level at which aid should be rendered. Workload models that use psychophysiological measures have the advantage of detecting workload continuously and relatively unobtrusively, although the inter-individual variability in psychophysiological responses to workload is a major challenge for many models. This study describes an approach to workload modeling with multiple psychophysiological measures that was generalizable across individuals, and yet accommodated inter-individual variability. Under this approach, several novel algorithms were formulated. Each of these underwent a process of evaluation which included comparisons of the algorithm’s performance to an at-chance level, and assessment of algorithm robustness. Further evaluations involved the sensitivity of the shortlisted algorithms at various threshold values for triggering an adaptive aid.
Identification of Cognitive Dysfunction in Patients with T2DM Using Whole Brain Functional Connectivity
Authors: Liu Zhenyu , Liu Jiangang , Yuan Huijuan , Liu Taiyuan , Cui Xingwei , Tang Zhenchao , Du Yang , Wang Meiyun , Lin Yusong , Tian Jie 
Published: November 2019

Abstract
Majority of type 2 diabetes mellitus (T2DM) patients are highly susceptible to several forms of cognitive impairments, particularly dementia. However, the underlying neural mechanism of these cognitive impairments remains unclear. We aimed to investigate the correlation between whole brain resting state functional connections (RSFCs) and the cognitive status in 95 patients with T2DM. We constructed an elastic net model to estimate the Montreal Cognitive Assessment (MoCA) scores, which served as an index of the cognitive status of the patients, and to select the RSFCs for further prediction. Subsequently, we utilized a machine learning technique to evaluate the discriminative ability of the connectivity pattern associated with the selected RSFCs. The estimated and chronological MoCA scores were significantly correlated with R = 0.81 and the mean absolute error (MAE) = 1.20. Additionally, cognitive impairments of patients with T2DM can be identified using the RSFC pattern with classification accuracy of 90.54% and the area under the receiver operating characteristic (ROC) curve (AUC) of 0.9737. This connectivity pattern not only included the connections between regions within the default mode network (DMN), but also the functional connectivity between the task-positive networks and the DMN, as well as those within the task-positive networks. The results suggest that an RSFC pattern could be regarded as a potential biomarker to identify the cognitive status of patients with T2DM.
Neuropsychological decline up to 20 years before incident mild cognitive impairment
Authors: Caselli Richard J. , Langlais Blake T. , Dueck Amylou C. , Chen Yinghua , Su Yi , Locke Dona E. C. , Woodruff Bryan K. , Reiman Eric M. 
Published: November 2019

AbstractIntroductionSome Alzheimer's disease biomarker studies found amyloid changes 20 years or more in advance of expected symptoms, while cognitive changes lagged for more than a decade, but this apparent lag might reflect the sensitivities of the biomarker and cognitive assays used. How far in advance of incident amnestic mild cognitive impairment (MCI) does cognition begin to decline?MethodsLongitudinal neuropsychological study of an apolipoprotein E e4 enriched cohort of cognitively normal individuals at entry. Linear mixed models for MCI converters (n = 65) and nonconverters (n = 719) fitted for each neuropsychological measure; annual changes compared between groups before and after linear model intersections (inflection points).Results34 of 35 cognitive measures and 9 of 18 behavioral measures declined faster post‐inflection in the MCI converters; the earliest cognitive inflection point was nearly 20 years in advance of MCI diagnosis.DiscussionThe preclinical duration of cognitive and behavioral changes approaches the earliest reported biomarker changes.
Comparing numerical ice-sheet model output with radio-echo sounding measurements in the Weddell Sea sector of West Antarctica
Authors: Jeofry Hafeez , Ross Neil , Siegert Martin J. 
Published: November 2019

AbstractNumerical ice-sheet models are commonly matched to surface ice velocities from InSAR measurements by modifying basal drag, allowing the flow and form of the ice sheet to be simulated. Geophysical measurements of the bed are rarely used to examine if this modification is realistic, however. Here, we examine radio-echo sounding (RES) data from the Weddell Sea sector of West Antarctica to investigate how the output from a well-established ice-sheet model compares with measurements of the basal environment. We know the Weddell Sea sector contains the Institute, Möller and Foundation ice streams, each with distinct basal characteristics: Institute Ice Stream lies partly over wet unconsolidated sediments, where basal drag is very low; Möller Ice Stream lies on relatively rough bed, where basal drag is likely larger; and Foundation Ice Stream is controlled by a deep subglacial trough with flow-aligned bedrock landforms and smooth unconsolidated sediments. In general, the ice-sheet model represents each ice-stream system well. We also find that ice velocities do not match perfectly in some locations, and that adjustment of the boundaries of low basal drag, to reflect RES evidence, should improve model performance. Our work showcases the usefulness of RES in calibrating ice-sheet model results with observations of the bed.
Novel Method of Extraction for Radiocarbon Measurements of Atmospheric Carbon dioxide
Authors: Pugsley K L , Knowles T D J , O’Doherty S 
Published: November 2019

ABSTRACTIn this paper, we present the first data from an alternative extraction method for atmospheric14CO2analysis, based on the direct trapping of whole air samples onto a molecular sieve zeolite (13X) trap, incorporated into a commercially available automated graphitization system. Results are presented for both inter-laboratory comparison samples and an in-house reference standard. The in-house reference was used to calculate the standard deviation of measurements (2.0‰). This newly developed method will facilitate faster sample processing and therefore lower cost per analysis, critical for scaling up such studies.
Soft tissue head and neck sarcoma: experience of a tertiary referral centre over a 15-year period
Authors: Harrison L , McCulloch T , Beasley N 
Published: November 2019

AbstractBackgroundHead and neck soft tissue sarcoma is uncommon. It is both histologically and clinically heterogeneous, ranging from an indolent, locally destructive tumour, to a locally aggressive neoplasm with metastatic potential.MethodsA retrospective review was conducted of all adult head and neck soft tissue sarcomas, including cases of malignant soft tissue sarcoma and all intermediate type tumours, diagnosed between 1997 and 2012.ResultsSixty-eight cases were identified in this series from the sarcoma multidisciplinary team. Seventeen different histological subtypes of sarcoma were identified. Neither age, gender nor tumour size were significant prognostic indicators for survival in this series.ConclusionPrognosis is dependent on histological subtype, underscoring the importance of histological classification. Some histological subtypes occur only once or twice in a decade, even within a large regional referral centre. An accumulation of evidence from relatively small case series is key in the long-term development of treatment strategies.
Extrinsic and intrinsic representations
Authors: Lehky Sidney R. , Sereno Anne B. 
Published: November 2019

Abstract
We extend the discussion in the target article about distinctions between extrinsic coding (external references to known things, as required by information theory) and the alternative we and the target article both favor, intrinsic coding (internal relationships within sensory and motor signals). Central to our thinking about intrinsic coding is population coding and the concept of high-dimensional neural response spaces.
Prediction, embodiment, and representation
Authors: Aranyosi István 
Published: November 2019

Abstract
First, I argue that there is no agreement within non-classical cognitive science as to whether one should eliminate representations, hence, it is not clear that Brette's appeal to it is going to solve the problems with coding. Second, I argue that Brette's criticism of predictive coding as being intellectualistic is not justified, as predictive coding is compatible with embodied cognition.