bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of the Autistic Behavior Checklist and the Childhood Autism Rating Scale for Suspected Autism in a Large Chinese Sample
Authors: Chu Jiahui , Bian Fang , Yan Ruiying , Li Yanlin , Cui Yonghua , Li Ying 
Published: August 2020

Abstract
Autism is the most common clinical developmental disorder in children. The Childhood Autism Rating Scale (CARS) and Autistic Behavior Checklist (ABC) are the most commonly used assessment scales for diagnosing autism. The aim of this study is to compare the diagnostic validities of CARS and ABC based on a large Chinese sample. A total of 474 children with suspected autism spectrum disorder (ASD) were screened by CARS and ABC. Receiver operating characteristic (ROC) curve analysis was performed and it showed that the area-under-the-curve values of CARS is higher than ABC significantly (p < 0.05) and the suggested cutoff values of CARS and ABC were 34 and 67, respectively. It indicated that CARS is superior to ABC in the Chinese population with suspected ASD.
Production and identification of two antifungal terpenoids from the Posidonia oceanica epiphytic Ascomycota Mariannaea humicola IG100
Authors: Botta Lorenzo , Saladino Raffaele , Barghini Paolo , Fenice Massimiliano , Pasqualetti Marcella 
Published: August 2020

Abstract
Background
Marine fungi are an important repository of bioactive molecules with great potential in different technological fields, the annual number of new compounds isolated from marine fungi is impressive and the general trend indicates that it is still on the rise. In this context, the antifungal and antimicrobial activity of the marine strain Mariannaea humicola IG100 was evaluated and two active terpenoids were isolated and characterized.
Methods
Preliminary screening of activity of marine strain IG100 was carried out by agar plug diffusion methods against fungal (P. griseofulvum TSF04) and bacterial (Bacillus pumilus KB66 and Escherichia coli JM109) strains. Subsequently, inhibition tests were done by using the cultural broth and the organic extract (ethyl acetate, EtOAc) by the agar well diffusion methods. The main active fractions were identified and tested for their antifungal activity against P. griseofulvum TSF04 in a 24 wells microplate at different concentrations (1000, 100, 10 and 1.0 µg/mL). Two active compounds were characterized and their relative MIC measured by the broth micro-dilution methods in a 96-well microplate against A. flavus IG133, P. griseofulvum TSF04, and T. pleuroticola IG137.
Results
Marine strain IG100 presented significant antifungal activity associated to two active compounds, the terpenoids terperstacin 1 and 19-acetyl-4-hydroxydictyodiol 2. Their MIC values were measured for Aspergillus flavus (MIC of 7.9 µg/mL and 31.3 µg/mL for 1 and 2, respectively), P. griseofulvum (MIC of 25 µg/mL and 100 µg/mL for 1 and 2, respectively) and T. pleuroticola (MIC > 500 µg/mL and 125 µg/mL for 1 and 2, respectively). They showed a rather good fungistatic effect.
Conclusions
In this study, the first marine strain of M. humicola (IG100) was investigated for the production of bioactive molecules. Strain IG100 produced significant amounts of two bioactive terpenoids, terperstacin 1 and 19-acetyl-4-hydroxydictyodiol 2. The two compounds showed significant antifungal activities against A. flavus IG133, T. pleuroticola IG137 and P. griseofulvum TSF04. Compound 2 was identified for the first time in fungi.
A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Shuilu Erxian Dan in Treating Diabetic Kidney Disease
Authors: Wu Tingchao , Yue Rensong , He Mingmin 
Published: August 2020

Abstract
Background and objective:

Recent years, some Chinese scholars have applied Shuilu Erxian Dan (SED) to the treatment of treating diabetic kidney disease (DKD) and achieved well curative effect. However, these studies are mostly limited to clinical observation. This study aimed to explore the molecular mechanisms of SED in treating DKD.
Methods

The active components of SED were retrieved in TCMSP database and BATMAN-TCM database, and the herbal targets were obtained by drugbank database and SwissTargetPrediction platform. The gene expression data of DKD patients were downloaded from GEO database and analyzed to obtain DKD-related targets. The ingredient-target network and the PPI network were constructed by Cytoscape software. The clusterProfiler package of R software is used for bioinformatic analysis. Molecular docking was further applied to verify the interaction between compounds and targets by Autodock Vina software.
Results

610 differential expressed genes of DKD patients were obtained, and 29 potential targets of SED against DKD were screened out (including PPTGS2, FABP3, HSD17B2, FABP1, HSD11B2, CYP27B1, JUN, UGT2B7, VCAM1, CA2, MAOA, MMP2, CXCR1, SLC22A6, EPHX2, SLC47A1, FOS, EGF, CCL2, COL3A1, GSTA1, GSTA2, HSPA1A, DAO, ALDH2, ALB, GPR18, FPR2, and LPL). All the active ingredients in SED can act on the DKD-related targets, among which quercetin, Ellagic acid, and kaempferol may be the key active compounds. SED may play a therapeutic role in DKD by regulating pathways including “Fluid shear stress and atherosclerosis”, “AGE − RAGE signaling pathway in diabetic complications” and “IL-17 signaling pathway”.
Conclusion

This study suggests that the mechanism of SED treating DKD is a complex network with multi-target and multi-pathway, which provides a reference for future experimental studies.
Mortality Data in Mechanically Ventilated COVID-19 patients admitted to ICU: A Retrospective Study in Brooklyn
Authors: Patti Ravi Karan , Duarte Claudia De Araujo , Dalsania Nishil , Thawani Rajat , Sinha Ankur , Gomes Bruno Augusto De Brito , Silver Michael , Seneviratne Chanaka , Somal Navjot , Kupfer Yihak 
Published: August 2020

Abstract
Background: High mortality rates are predominant even in COVID-19 patients requiring minimal supportive therapy, with a short-coming of data on COVID-19 patients requiring mechanical ventilation.Objectives/Design: We performed a single-center, retrospective, cohort study at a tertiary care, community-based teaching hospital with patient who required invasive mechanical ventilatory support and were COVID-19 positive. All patients were treated according to the ARDSnet protocol. The primary outcome was overall mortality, and secondary outcome was successful extubation.Results: A total of 72 COVID-19 positive intubated patients were included. Twenty-six (66.6%) patients died within the first 15 days of hospital admission; thirty-eight (52.7%) died within 28 days, and thirty-nine (54.2%) died within 29 days. A total of 22 patients (30.5%) were successfully extubated. 15 patients (20.8%) who required reintubation or could not be extubated further underwent tracheostomy.Conclusions: Mortality of critically ill COVID-19 patients requiring mechanical ventilatory support is high, our observed mortality rate (54.2%) was significantly lower than currently published reports. We believe our rate to be a consequence of early intubation in conjunction with adherence to ARDSnet protocol. We also observed patients with hyperlipidemia, higher CRP, renal failure, or those requiring vasopressor use had worse outcomes.
Blood biomarkers for assessing headaches in healthcare workers after wearing biological personal protective equipment in a COVID-19 field-hospital
Authors: Martín-Rodríguez Francisco , Rubiales Raquel M. Portillo , Millán Laura N. Fadrique , Rodríguez Virginia Carbajosa , Sanz-García Ancor , Herrera Gabino Mozo , Ortega Guillermo J. , Ballester Esther Durá , Villamor Miguel Ángel Castro , Izquierdo Raúl López 
Published: August 2020

Abstract
The consequences of wearing biosafety equipment by healthcare professionals during their work and the prediction of such consequences need to be assessed. To analyze the role played by different blood biomarkers in predicting the appearance of headaches in healthcare workers wearing personal protective equipment (PPE) in a COVID-19 treatment unit, a Prospective cohort study of 38 healthcare workers from a convalescence unit of patients with COVID-19 in a field hospital was performed during April 2020. Blood analysis was carried out before the start of the 4 hours shift of the volunteers equipped with PPE. After decontamination, there were asked if they had suffered from headache, obtaining the binary outcome. This study included 38 participants with a median age of 29 years (25th-75th percentile: 26-44 years old), 73.7% female (28 cases). 44.7% (17 cases) had a headache after wearing PPE for 4 hours. The baseline creatinine value reflected a specific odds ratio in the regression model of 241.36 (95% CI: 2.50-23,295.43; p=0.019), and an AUC of 0.737 (95%CI: 0.57-0.90; p<0.01). Blood creatinine is a good candidate for predicting the appearance of a de novo headache in healthcare workers after wearing PPE for 4 hours in a COVID – 19 unit.
O MARCO DA CARTA DEMOCRÁTICA INTERAMERICANA E SUA INTERPRETAÇÃO NO PROCESSO DE IMPEACHMENT DA PRESIDENTE DILMA ROUSSEFF: REPENSANDO A DEMOCRACIA
Authors: Teixeira Marques Verônica , Galvão Vivianny 
Published: August 2020

Após repensar a categoria de democracia a partir dos teóricos clássicos e contemporâneos, como analisar a posição da CoIDH, acerca da solicitação de opinião consultiva feita pelo Secretário Geral da Organização dos Estados Americanos, a respeito do processo de impeachment da Presidente Dilma Rousseff? O objetivo deste artigo foi, por meio de um estudo de caso, repensar os contornos da democracia. Verificou-se que a CoIDH negou o prosseguimento do pedido acerca da legitimidade do impeachment por unanimidade, ou seja, a Corte “opinou por não opinar”. Levando-se em consideração que o sistema interamericano considera a Carta como manifesto em favor da democracia representativa nas Américas propondo um conceito de democracia que transcende a ideia de democracia eleitoral, a decisão da Corte respeita as bases jurídicas da legislação internacional mas é contraditória à da transcendência democrática que vai além do voto. A metodologia utilizada foi qualitativa com método de estudo de caso.
Improving wastewater treatment plants operational efficiency and effectiveness through an integrated performance assessment system
Authors: Cassidy J. , Silva T. , Semião N. , Ramalho P. , Santos A. , Feliciano J. 
Published: August 2020

Abstract
Optimizing the efficiency of urban water systems is a growing concern for water utilities worldwide. Wastewater treatment plants (WWTP) are crucial in maintaining water quality and resource recovery in a world facing growing challenges such as climate change, water-energy-food nexus and the increase of legal requirements and users' expectations. Thus, adopting a performance assessment system (PAS) is of the utmost importance to assess operating conditions and to identify critical aspects of the WWTP which can negatively affect its effectiveness, efficiency and reliability. This paper presents the global and operational performance assessment of an urban WWTP and identifies improvement measures. The WWTP presented a good performance in terms of effectiveness and reliability. Nevertheless, in terms of efficiency, relevant improvement opportunities were identified, specifically in the sludge treatment phase and in terms of energy management. PAS was proven to be successful in the identification and prioritization of rehabilitation needs in a systematic way which will continuously improve the efficiency and effectiveness of the WWTP as well as to support asset management decisions regarding their upgrade and retrofit.
Dynamics and Development of the COVID-19 Epidemic in the United States: A Compartmental Model Enhanced With Deep Learning Techniques
Authors: Deng Qi 
Published: August 2020

Background
Compartmental models dominate epidemic modeling. Transmission parameters between compartments are typically estimated through stochastic parameterization processes that depends on detailed statistics of transmission characteristics, which are economically and resource-wise expensive to collect.

Objective
We aim to apply deep learning techniques as a lower data dependency alternative to estimate transmission parameters of a customized compartmental model, for the purpose of simulating the dynamics of the US coronavirus disease (COVID-19) epidemic and projecting its further development.

Methods
We constructed a compartmental model and developed a multistep deep learning methodology to estimate the model’s transmission parameters. We then fed the estimated transmission parameters to the model to predict development of the US COVID-19 epidemic for 35 and 42 days. Epidemics are considered suppressed when the basic reproduction number (R0) is less than 1.

Results
The deep learning–enhanced compartmental model predicts that R0 will fall to <1 around August 17-19, 2020, at which point the epidemic will effectively start to die out, and that the US “infected” population will peak around August 16-18, 2020, at 3,228,574 to 3,308,911 individual cases. The model also predicted that the number of accumulative confirmed cases will cross the 5 million mark around August 7, 2020.

Conclusions
Current compartmental models require stochastic parameterization to estimate the transmission parameters. These models’ effectiveness depends upon detailed statistics on transmission characteristics. As an alternative, deep learning techniques are effective in estimating these stochastic parameters with greatly reduced dependency on data particularity.
Entre el distanciamiento y la conectividad
Authors: Martin María Victoria , Kap Miriam , Génova Elena 
Published: August 2020

El distanciamiento social obligatorio impuesto por el avance del COVID-19 condujo a poner en cuestión la normalidad y repercutió inmediatamente en las aulas. La suspensión de clases presenciales presentó un gran desafío, y fueron los/as docentes quienes rápidamente buscaron alternativas para garantizar la continuidad pedagógica y vincularse con sus estudiantes. Las experiencias de enseñanza y de aprendizaje mutaron y generaron nuevas formas de apropiación, de producción y de consumo dentro de la compleja ecología de medios. Experiencias didácticas transformadoras se fueron presentando en contextos diversos en ambientes con y sin disposición tecnológica.
Juventudes y comunicación política
Authors: Secul Giusti Cristian 
Published: August 2020

El artículo recupera un trabajo realizado en contexto pandémico y en el marco de las clases de la asignatura Estudios sobre Política y Sociedad II de la Tecnicatura Superior en Comunicación Pública y Política de Facultad de Periodismo y Comunicación Social (UNLP), donde se abordaron los pensamientos políticos de Simone de Beauvoir y Hannah Arendt presentes en «Idealismo moral y realismo político» (1948) y «¿Qué es la política?» (1950). Dicho acercamiento permitió analizar planteos existencialistas y de transformación en pos de una reivindicación de la política y de la pluralidad como concepción fundamental para atravesar dificultades y complejidades sociales.
DETERMINE REGIONAL STRATEGY IN IMPROVING THE COMPETITIVENESS OF AGRICULTURAL COMMODITIES IN GLOBAL MARKETS
Authors: Rum Irlan Adiyatma , Rijoly Jacobus Cliff Diky 
Published: August 2020

Trade liberalization has affected Indonesian economy. The country success in international trade is truly determined by the regional sectoral competitiveness. The government recognized that agricultural commodities have higher degree of vulnerability to global trade pressures due to weak competitiveness. This study tried to identify the regional strategies that could be taken by the government in improving the competitiveness of agricultural commodity and determine the optimal solution that need to be considered. To determine the position of agricultural competitiveness, calculated Revealed Comparative Advantage (RCA), Revealed Comparative Trade Advantage (RCTA), and Trade Specialization Index (TSI) for some strategic commodities in agricultural Indonesia to export destinations. The results show that Indonesia experienced a decline in their competitiveness in global trade. It has been proved from the comparation over time and with other export countries. This study proposes regional strategy to improve national competitiveness based on their regional competitiveness.
Analisis Perbandingan Biaya pada Pekerjaan Pengerukan di Alur Pelabuhan Bandar Bakau Jaya Banten
Authors: Firdaus Aden , Rizkiansyah Muhammad , Nirwana Yessi 
Published: August 2020

ABSTRAKPelabuhan Bandar Bakau Jaya yang terletak di Provinsi Banten saat ini dapat melayani kapal yang berjenis 5.000 DWT, dan rencananya akan melayani kapal 10.000 DWT. Pekerjaan pengerukan akan dilakukan pada Alur Pelabuhan dengan dimensi panjang 2.391 m dengan jenis tanah adalah tanah halus berpasir. Tujuan dari penelitian ini adalah membandingkan biaya dan waktu pelaksanaan dari masing- masing jenis kapal keruk yang dapat melakukan pekerjaan pengerukan dengan kondisi tanah yang ada di alur pelabuhan. Metode yang digunakan adalah dengan memperhitungkan berapa lama waktu pekerjaan pengerukan sehingga didapatkan biaya dari masing-masing jenis kapal keruk. Hasil dari analisis didapatkan 3 jenis kapal keruk yaitu, TSHD dalam waktu 2,11 bulan dan biaya Rp27.316.912.819,63, SD dalam waktu 8,34 bulan dan biaya Rp27.887.202.652,35, dan CSD dalam waktu 6,08 bulan dan biaya Rp37.995.671.214,00. Jenis kapal keruk yang paling efisien untuk pekerjaan pengerukan di alur pelabuhan ini adalah TSHD dengan 7 tugboat dan barge.Kata kunci: pengerukan, alur pelayaran, kapal keruk ABSTRACTBandar Bakau Jaya Port, located in Banten Province, currently serves 5,000 DWT vessels, and it is planned to serve 10,000 DWT vessels. Dredging work will be carried out on the Port Channel with a dimension of 2,391 m in length with a fine sandy soil type. The purpose of this study is to compare the cost and implementation time of each type of dredger that can carry out dredging work with existing soil conditions in the port channel. The method used is to calculate how long the dredging work is so that the cost of each type of dredger is obtained. The results of the analysis found 3 types of dredges namely, TSHD in 2.11 months and costs Rp27,316,912,819.63, SD in 8.34 months and costs Rp27,887,202,652.35, and CSD in 6, 08 months and costs Rp37,995,671,214.00. The most efficient type of dredger for this work is TSHD with 7 tugboats and barges.Keywords: dredging, fairway, dredger
Evaluasi Keandalan Jembatan Gantung Pejalan Kaki Dengan Variasi Letak dan Jenis Beban Lalu Lintas
Authors: Widyaningsih Euneke 
Published: August 2020

ABSTRAKUntuk mendukung pembangunan infrastruktur jembatan, pemerintah mengeluarkan panduan untuk perencanaan jembatan gantung dengan judul Surat Edaran Menteri Pekerjaan Umum No. 02/SE/M/2010 tentang Pemberlakukan Pedoman Perencanaan dan Pelaksanaan Konstruksi Jembatan Gantung Untuk Pejalan Kaki. Jembatan gantung yang dirancang sesuai dengan panduan tersebut harus mampu menahan beban pejalan kaki sebesar 5 kPa. Dengan mengacu pada pedoman tersebut, direncanakanlah sebuah jembatan gantung dengan panjang total 127.34 meter. Agar dapat mengetahui perilaku jembatan terhadap beban yang direncanakan, dibuatlah pemodelan jembatan menggunakan software MidasCIVIL dengan menggunakan 4 variasi letak pembebanan dan 80 variasi beban mewakili bobot pejalan kaki dan kendaraan bermotor roda dua. Tujuan dilakukannya analisis ini adalah untuk mengetahui nilai keandalan struktur yang direncanakan dengan beban sesuai Surat Edaran Menteri Pekerjaan Umum No. 02/SE/M/2010 terhadap variasi beban pejalan kaki dan kendaraan bermotor yang sesungguhnya mungkin terjadi pada jembatan. Evaluasi struktur menggunakan metode probability based menghasilkan keandalan struktur jembatan sebesar 100% yang dianalisis terhadap lendutan, tegangan kabel, tegangan batang penggantung serta tegangan pilar. Sehingga dapat dikatakan bahwa beban 5 kPa yang disyaratkan oleh pedoman memiliki nilai yang konservatif dan akan menghasilkan struktur jembatan yang sangat aman.Kata kunci: : Jembatan Gantung, Variasi Letak Beban, Pejalan Kaki, Probability Based Design ABSTRACTTo support the establishment of bridge infrastructure, the government issued a guide for planning a suspension bridge with the title Surat Edaran Menteri Pekerjaan Umum No. 02 / SE / M / 2010 concerning the Implementation of Guidelines for Planning and Construction of Suspension Bridges for Pedestrians. Suspension bridges designed according to these guidelines must be able to withstand pedestrian loads of 5 kPa. With reference to these guidelines, a suspension bridge is planned with a total length of 127.34 meters. In order to know the bridge's behavior towards the planned load, a bridge modeling was made using MidasCIVIL using 4 position of loading and 80 load variations representing pedestrian weight and two-wheeled motorized vehicles. The purpose of this analysis is to determine the value of the bridge reliability that planned with load according to the Surat Edaran Menteri Pekerjaan Umum No. 02 / SE / M / 2010 against variations in pedestrian and motor vehicle loads that might actually occur on bridges. Structural evaluation using probability-based methods produces 100% bridge structure reliability which is analyzed for deflection, cable stress, hanger stress and pillar stress. So, it can be said that the 5 kPa load required by the guidelines has a conservative value and will produce a very safe bridge structure.Keywords: Suspension Bridge, Load Position Variation, Pedestrian, Probability Based Design
Evaluasi Perbaikan Tanah Menggunakan Rapid Impact Compaction pada Tanah Berpotensi Likuefaksi
Authors: Pratiwi Desti Santi 
Published: August 2020

ABSTRAKRapid Impact Compaction (RIC) merupakan salah satu metode perbaikan tanah secara mekanik untuk tanah granular. Prinsip dasar dari Rapid Impact Compaction yaitu menjatuhkan beban hammer dengan tinggi jatuh yang relatif rendah dengan kecepatan yang tinggi. RIC dapat dijadikan alternatif dalam mitigasi likuefaksi. Beberapa penelitian sebelumnya menyatakan bahwa RIC dapat memperbaiki tanah hingga kedalaman 6 m. Pada penelitian ini, evaluasi efektifitas perbaikan tanah menggunakan RIC dilakukan di lokasi Pembangunan New Yogyakarta International Airport Kulon Progo. Pada lokasi tersebut terdapat tanah pasir lepas dan berpotensi likuefaksi hingga kedalaman 8m. Analisis yang dilakukan yaitu membandingkan nilai Standard Penetration Test (SPT) sebelum dan setelah perbaikan tanah dengan RIC. Hasil analisis menunjukkan bahwa terdapat kenaikan nilai SPT sebesar 10 – 12, sehingga dapat memehuni kriteria desain yang telah ditentukan untuk mitigasi likuefaksi.Kata kunci: perbaikan tanah, likuefaksi, Rapid Impact Compaction, SPT. ABSTRACTRapid Impact Compaction (RIC) is one of mechanical ground improvement technique that suitable for granular soil material. The principle of this method is repeatedly strike an impact plate on the ground surface using a hydraulic hammer. RIC can be implemented as an alternative for liquefaction mitigation. Some previous studies have stated that RIC can improve the soil to a depth of 6 m. The evaluation of effectiveness RIC to improving problematic soil was taken in New Yogyakarta International Airport project. At the project site, the soil condition is consist of loose sand and potential to be liquefied up to 8 m depth. The analysis has donne by comparing the SPT value before and after improving by RIC. The result of analysis gave an information that there is an increace SPT value of 10 – 12, so it can meet with the design criteria for mitigation of liquefaction.Keywords: ground improvement, liquifaction, Rapid Impact Compaction, SPT.