bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depicting Human Form
Authors: Cumhaill Clare Mac 
Published: June 2020

AbstractThis paper involves constructive exegesis. I consider the contrast between morality and art as sketched in Philippa Foot's 1972 paper of the same name, ‘Morality and Art’. I then consider how her views might have shifted against the background of the conceptual landscape afforded by Natural Goodness (2001), though the topic of the relation of art and morality is not explicitly explored in that work. The method is to set out some textual fragments from Natural Goodness that can be arranged for a tentative Footian ‘aesthetics’. I bring them into conversation with some ideas from Iris Murdoch to elucidate what I think the import may be, for Foot, of depicting human form.
Using a citizens’ jury approach to determine a good nutrition resource for pregnant women
Authors: Coppell Kirsten J , Paterson Helen , Norton Joanna , Jeffs Emma , Hay-Smith E Jean C 
Published: June 2020

AbstractObjective:The development of user-friendly nutrition resources for pregnant women seldom involves end-users. This qualitative study used a citizens’ jury approach to determine if our modification of a longstanding, frequently used dietitian-informed diet and diabetes booklet was deemed to be a good healthy eating resource for pregnant women.Design:Midwives recruited thirteen first-time pregnant women not requiring specialist obstetric care or specialist dietetic advice for any reason. Participants were sent a copy of the modified healthy eating in pregnancy booklet prior to ‘jury day’. Five women were unable to attend the citizens’ jury citing reasons such as early labour. At the jury, five experts presented evidence. Participants adjourned, with an independent facilitator, to ‘deliberate’ as to whether the resource was suitable or not. The verdict was presented, and subsequent discussion was audio-recorded, transcribed and inductively content analysed.Setting:Southland, New Zealand.Participants:Pregnant women aged 19–35 years (n 8), of whom half had a household income <$NZ30 000.Results:The verdict was ‘Yes’; the resource was good. Three themes were derived: communication of health information, resource content and harm reduction in pregnancy. Based on these data, ways to enhance the quality and usability of the booklet were evident.Conclusions:Citizens’ juries can be used to obtain an independent assessment by end-users of health resources. Our modified diet and diabetes booklet was considered suitable for providing healthy eating advice to pregnant women. Inclusion of end-users’ perspectives is critical for end-user relevant content, comprehension and resource credibility.
Twins Reared Apart: Zygotic Division After Artificial Insemination/Twin Research Reviews: Selective Resuscitation of Premature Twins; Scientist Jailed for Editing Twins’ Genes; Sexual Arousal Patterns in MZ Twins Discordant for Sexual Orientation; MZ Twins With Jejuno-Ileal Atresia/Media Reports: Twin Girls’ Search for a Bone Marrow Donor; Puppy with a Possible Parasitic Twin; Twins in Silicon Valley; Surgical Separation of Craniopagus Twins; Twin-BasedNew Yorker MagazineCartoon; Twin Tragedies
Authors: Segal Nancy L. 
Published: June 2020

AbstractThis article opens with the brief life histories of reared-apart monozygotic (MZ) male twins. A New York City program that helped childless couples conceive via artificial insemination from the 1930s to the 1950s is examined as it related to these twins. The frequency with which pregnancies following assisted reproductive technology resulted in MZ twin pairs is also provided. Next, summaries of twin research concerning selective resuscitation, gene editing, sexual arousal and jejuno-ileal atresia are presented. The article ends with media reports of twin girls’ efforts to find a bone marrow donor for their father, possible parasitic twinning in a puppy, identical female twins’ business venture, the surgical separation of craniopagus twins, a twin-themed magazine cartoon and tragic events involving identical male twins.
Pricing Immigration
Authors: Hix Simon , Kaufmann Eric , Leeper Thomas J. 
Published: June 2020

AbstractImmigration is highly salient for voters in Europe and the USA and has generated considerable academic debate about the causes of preferences over immigration. This debate centers around the relative influences of sociotropic or personal economic considerations, as well as noneconomic threats. We provide a test of the competing egocentric, sociotropic, and noneconomic paradigms using a novel constrained preference experiment in which respondents are asked to trade off preferred reductions in immigration levels with realistic estimates of the personal or societal costs associated with those reductions. This survey experiment, performed on a national sample of British YouGov panelists, allows us to measure the price-elasticity of the publicʼs preferences with regard to levels of European and non-European immigration. Respondents were willing to admit more immigrants when restriction carries economic costs, with egocentric considerations as important as sociotropic ones. People who voted for the UK to Leave the European Union in the 2016 referendum are less price-elastic than those voting Remain, indicating that noneconomic concerns are also important.1
Lagrangian Modeling of Mixing‐Limited Reactive Transport in Porous Media: Multirate Interaction by Exchange With the Mean
Authors: Sole‐Mari Guillem , Fernàndez‐Garcia Daniel , Sanchez‐Vila Xavier , Bolster Diogo 
Published: June 2020

AbstractThe presence of solute concentration fluctuations at spatial scales much below the scale of resolution is a major challenge for modeling reactive transport in porous media. Overlooking small‐scale fluctuations, which is the usual procedure, often results in strong disagreements between field observations and model predictions, including, but not limited to, the overestimation of effective reaction rates. Existing innovative approaches that account for local reactant segregation do not provide a general mathematical formulation for the generation, transport, and decay of these fluctuations and their impact on chemical reactions. We propose a Lagrangian formulation based on the random motion of fluid particles carrying solute concentrations whose departure from the local mean is relaxed through multirate interaction by exchange with the mean (MRIEM). We derive and analyze the macroscopic descriptionof the local concentration covariance that emerges from the model, showing its potential to simulate the dynamics of mixing‐limited processes. The action of hydrodynamic dispersion on coarse‐scale concentration gradients is responsible for the production of local concentration covariance, whereas covariance destruction stems from the local mixing process represented by the MRIEM formulation. The temporal evolution of integrated mixing metrics in two simple scenarios shows the trends that characterize fully resolved physical systems, such as a late‐time power law decay of the relative importance of incomplete mixing with respect to the total mixing. Experimental observations of mixing‐limited reactive transport are successfully reproduced by the model.
Neural responsivity to social rewards in autistic female youth
Authors: Lawrence Katherine E. , Hernandez Leanna M. , Eilbott Jeffrey , Jack Allison , Aylward Elizabeth , Gaab Nadine , Van Horn John D. , Bernier Raphael A. , Geschwind Daniel H. , McPartland James C. , Nelson Charles A. , Webb Sara J. , Pelphrey Kevin A. , Bookheimer Susan Y. , Dapretto Mirella ,   on behalf of the GENDAAR Consortium, Aylward Elizabeth , Bernier Raphael A. , Bookheimer Susan Y. , Dapretto Mirella , Gaab Nadine , Geschwind Daniel H. , Jack Allison , McPartland James C. , Nelson Charles A. , Pelphrey Kevin A. , Van Horn John D. , Webb Sara J. , Ankenman Katy , Corrigan Sarah , Depedro-Mercier Dianna , Guilford Desiree , Gupta Abha R. , Jacokes Zachary , Jeste Shafali , Keifer Cara M. , Kresse Anna , Libsack Erin , Lowe Jennifer K. , MacDonnell Erin , McDonald Nicole , Naples Adam , Neuhaus Emily , Sullivan Catherine A. W. , Tsapelas Heidi , Torgerson Carinna M. , Ventola Pamela , Welker Olivia , Wolf Julie 
Published: June 2020

AbstractAutism is hypothesized to be in part driven by a reduced sensitivity to the inherently rewarding nature of social stimuli. Previous neuroimaging studies have indicated that autistic males do indeed display reduced neural activity to social rewards, but it is unknown whether this finding extends to autistic females, particularly as behavioral evidence suggests that affected females may not exhibit the same reduction in social motivation as their male peers. We therefore used functional magnetic resonance imaging to examine social reward processing during an instrumental implicit learning task in 154 children and adolescents (ages 8–17): 39 autistic girls, 43 autistic boys, 33 typically developing girls, and 39 typically developing boys. We found that autistic girls displayed increased activity to socially rewarding stimuli, including greater activity in the nucleus accumbens relative to autistic boys, as well as greater activity in lateral frontal cortices and the anterior insula compared with typically developing girls. These results demonstrate for the first time that autistic girls do not exhibit the same reduction in activity within social reward systems as autistic boys. Instead, autistic girls display increased neural activation to such stimuli in areas related to reward processing and salience detection. Our findings indicate that a reduced sensitivity to social rewards, as assessed with a rewarded instrumental implicit learning task, does not generalize to affected female youth and highlight the importance of studying potential sex differences in autism to improve our understanding of the condition and its heterogeneity.
No association between FKBP5 gene methylation and acute and long-term cortisol output
Authors: Alexander Nina , Kirschbaum Clemens , Stalder Tobias , Muehlhan Markus , Vogel Susanne 
Published: June 2020

AbstractPrior studies identified DNA methylation (DNAM) changes in a regulatory region within the FK506 binding protein 5 (FKBP5) gene as a crucial mediator of long-term negative health outcomes following early adversity. A critical mechanism underlying this link, in turn, has been suggested to be epigenetically induced dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis. The purpose of this study was thus to investigate associations of FKBP5 DNAM with both acute and chronic cortisol output. Two hundred adults with differential exposure to childhood trauma (CT) were underwent a laboratory stressor (Trier Social Stress Test) and provided salivary samples for the analysis of acute cortisol stress responses. In addition, hair cortisol concentrations were determined as a valid measure of integrated long-term cortisol levels. Whole blood samples were drawn for DNAM analyses of FKBP5 intron 7 via bisulfite pyrosequencing. In contrast to most prior work, only healthy participants were included in order to disentangle the effects of trauma exposure per se from those related to mental disorders. First, our findings did not reveal strong evidence for a robust effect of CT on FKBP5 intron 7 DNAM status, even if genetic predisposition (rs1360780 genotype) was taken into account. Second, FKBP5 DNAM levels were found to be unrelated to acute cortisol stress reactivity and long-term cortisol concentration in hair. The failure to demonstrate a significant association between CT and FKBP5 DNAM in an exclusively healthy sample could be interpreted as suggesting that individuals’ mental health status may be a critical modulator of previously observed effects.
Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation
Authors: Garcia-Mompo Clara , Curto Yasmina , Carceller Hector , Gilabert-Juan Javier , Rodriguez-Flores Esther , Guirado Ramon , Nacher Juan 
Published: June 2020

AbstractThe prefrontal cortex (PFC) continues its development during adolescence and alterations in its structure and function, particularly of inhibitory networks, have been detected in schizophrenic patients. Since cannabis use during adolescence is a risk factor for this disease, our main objective was to investigate whether THC administration during this period might exacerbate alterations in prefrontocortical inhibitory networks in mice subjected to a perinatal injection of MK801 and postweaning social isolation. This double-hit model (DHM) combines a neurodevelopmental manipulation and the exposure to an aversive experience during early life; previous work has shown that DHM mice have important alterations in the structure and connectivity of PFC interneurons. In the present study we found that DHM had reductions in prepulse inhibition of the startle reflex (PPI), GAD67 expression and cingulate 1 cortex volume. Interestingly, THC by itself induced increases in PPI and decreases in the dendritic complexity of somatostatin expressing interneurons. Both THC and DHM reduced the density of parvalbumin expressing cells surrounded by perineuronal nets and, when combined, they disrupted the ratio between the density of puncta expressing excitatory and inhibitory markers. Our results support previous work showing alterations in parameters involving interneurons in similar animal models and schizophrenic patients. THC treatment does not modify further these parameters, but changes some others related also to interneurons and their plasticity, in some cases in the opposite direction to those induced by the DHM, suggesting a protective effect.
Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice
Authors: Emmerzaal Tim L. , Preston Graeme , Geenen Bram , Verweij Vivienne , Wiesmann Maximilian , Vasileiou Elisavet , Grüter Femke , de Groot Corné , Schoorl Jeroen , de Veer Renske , Roelofs Monica , Arts Martijn , Hendriksen Yara , Klimars Eva , Donti Taraka R. , Graham Brett H. , Morava Eva , Rodenburg Richard J. , Kozicz Tamas 
Published: June 2020

AbstractMitochondria play a critical role in bioenergetics, enabling stress adaptation, and therefore, are central in biological stress responses and stress-related complex psychopathologies. To investigate the effect of mitochondrial dysfunction on the stress response and the impact on various biological domains linked to the pathobiology of depression, a novel mouse model was created. These mice harbor a gene trap in the first intron of the Ndufs4 gene (Ndufs4GT/GT mice), encoding the NDUFS4 protein, a structural component of complex I (CI), the first enzyme of the mitochondrial electron transport chain. We performed a comprehensive behavioral screening with a broad range of behavioral, physiological, and endocrine markers, high-resolution ex vivo brain imaging, brain immunohistochemistry, and multi-platform targeted mass spectrometry-based metabolomics. Ndufs4GT/GT mice presented with a 25% reduction of CI activity in the hippocampus, resulting in a relatively mild phenotype of reduced body weight, increased physical activity, decreased neurogenesis and neuroinflammation compared to WT littermates. Brain metabolite profiling revealed characteristic biosignatures discriminating Ndufs4GT/GT from WT mice. Specifically, we observed a reversed TCA cycle flux and rewiring of amino acid metabolism in the prefrontal cortex. Next, exposing mice to chronic variable stress (a model for depression-like behavior), we found that Ndufs4GT/GT mice showed altered stress response and coping strategies with a robust stress-associated reprogramming of amino acid metabolism. Our data suggest that impaired mitochondrial CI function is a candidate driver for altered stress reactivity and stress-induced brain metabolic reprogramming. These changes result in unique phenomic and metabolomic signatures distinguishing groups based on their mitochondrial genotype.
The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasion
Authors: Liu Songsong , Zhang Junfeng , Yin Liangyu , Wang Xianxing , Zheng Yao , Zhang Yujun , Gu Jianyou , Yang Ludi , Yang Jiali , Zheng Ping , Jiang Yan , Shuai Ling , Cai Xiongwei , Wang Huaizhi 
Published: June 2020

AbstractNumerous long noncoding RNAs (lncRNAs) are aberrantly expressed in pancreatic cancer (PC); however, their functions and mechanisms in cancer progression are largely unknown. In this study, we identified a novel PC-associated lncRNA, RUNX1-IT1, that was significantly upregulated in PC patient samples from multiple centers and associated with poor prognosis. In vitro and in vivo, alterations in RUNX1-IT1 expression markedly affected PC proliferation, migration and invasion. RUNX1-IT1 contributed to the progression of PC by interacting with the adjacent gene RUNX1. Rescue experiments showed that RUNX1 reduced the cancer-promoting effect of RUNX1-IT1. RNA-seq analysis after silencing RUNX1-IT1 and RUNX1 highlighted alterations in the common target C-FOS. Mechanistically, we demonstrated that RUNX1-IT1 was a trans-acting factor that participated in the proliferation, migration and invasion of PC by recruiting RUNX1 to the C-FOS gene promoter. Furthermore, RUNX1-IT1 enhanced the transcription of the RUNX1 gene, indicating its potential as a cis-regulatory RNA involved in the upstream regulation of RUNX1. Overall, RUNX1-IT1 is a crucial oncogenic lncRNA that activates C-FOS expression by regulating and recruiting RUNX1 and is a potential prognostic biomarker and therapeutic target for PC.
The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study
Authors: Yilmaz Mahmut Ilker , Romano Micol , Basarali Mustafa Kemal , Elzagallaai Abdelbaset , Karaman Murat , Demir Zeynep , Demir Muhammet Fatih , Akcay Fatih , Seyrek Melik , Haksever Nuri , Piskin David , Cimaz Rolando , Rieder Michael J. , Demirkaya Erkan 
Published: June 2020

AbstractWhile the pathophysiology of chronic disorders varies there are three basic mechanisms - inflammation, oxidative stress and endothelial dysfunction – that are common in many chronic diseases. However, the failure of these mechanisms to work synchronously can lead to morbidity complicating the course of many chronic diseases. We analyzed data of 178 patients from cohorts with selected chronic diseases in this quasi-experimental study. Endothelial dysfunction was determined by flow-mediated dilatation (FMD) and asymmetric dimethylarginine (ADMA) levels. Serum ADMA, high sensitive C-reactive protein (hs-CRP), serum PTX3, malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), glutathione peroxidase (GSH-Px) levels and FMD were studied in baseline and after 12 weeks of Morinda citrifolia (anti-atherosclerotic liquid- AAL), omega-3 (anti-inflammatory capsules- AIC) and extract with Alaskan blueberry (anti-oxidant liquid- AOL). Stepwise multivariate regression analysis was used to evaluate the association of FMD with clinical and serologic parameters. Serum ADMA, MDA, PTX3, hsCRP and albumin levels, and proteinuria were significantly decreased while CuZn-SOD, GSH-Px and FMD levels were significantly increased following AAL, AIC and AOL therapies. The FMD was negatively correlated with serum ADMA, MDA, PTX3, and hsCRP levels and positively correlated with CuZn-SOD and eGFR levels. ADMA and PTX3 levels were independently related to FMD both before and after AAL, AIC and AOL therapies. Our study shows that serum ADMA, MDA, PTX3 levels are associated with endothelial dysfunction in patients with selected chronic diseases. In addition, short-term AAL, AIC and AOL therapies significantly improves a number of parameters in our cohort and can normalize ADMA, PTX3, hsCRP and MDA levels.
A species-specific miRNA participates in biomineralization by targeting CDS regions of Prisilkin-39 and ACCBP in Pinctada fucata
Authors: Zhu Xuejing , Chen Yan , Zhang Zhen , Zhao Shuyan , Xie Liping , Zhang Rongqing 
Published: June 2020

AbstractBiomineralization is a sophisticated biological process precisely regulated by multiple molecules and pathways. Accumulating miRNAs have been identified in invertebrates but their functions in biomineralization are poorly studied. Here, an oyster species-specific miRNA, novel_miR_1 was found to regulate biomineralization in Pinctada fucata. Target prediction showed that novel_miR_1 could target Prisilkin-39 and ACCBP by binding to their coding sequences (CDS). Tissue distribution analysis revealed that the expression level of novel_miR_1 was highest in the mantle, which was a key tissue participating in biomineralization. Gain-of-function assay in vivo showed that biomineralization-related genes including Prisilkin-39 and ACCBP were down-regulated and shell inner surfaces of both prismatic and nacreous layer were disrupted after the over-expression of novel_miR_1, indicating its dual roles in biomineralization. Furthermore, the shell notching results indicated that novel_miR_1 was involved in shell regeneration. Dual-luciferase reporter assay in vitro demonstrated that novel_miR_1 directly suppressed Prisilkin-39 and ACCBP genes by binding to the CDS regions. Taken together, these results suggest that novel_miR_1 is a direct negative regulator to Prisilkin-39 and ACCBP and plays an indispensable and important role in biomineralization in both prismatic and nacreous layer of P. fucata.
Sub-arctic palsa degradation and the role of climatic drivers in the largest coherent palsa mire complex in Sweden (Vissátvuopmi), 1955–2016
Authors: Olvmo Mats , Holmer Björn , Thorsson Sofia , Reese Heather , Lindberg Fredrik 
Published: June 2020

AbstractSubstantial palsa degradation has occurred in Fennoscandia, which is considered to be driven by global climate change. Deeper understanding of the role of different climatic drivers on palsa decay, however, is lacking. We use meteorological data and aerial photographs from 1955 to 2016 to statistically identify the most important climatic drivers affecting changes in lateral-temporal palsa decay rates in the largest coherent palsa complex in Sweden, Vissátvuopmi. We show that wetter, warmer and shorter winters are the main causes of large and rapid changes in lateral-palsa extent since the mid-1950s. By analyzing meteorological data from the 1880s to present, we show that average annual temperature conditions have been unfavourable for palsas for more than a century and average annual precipitation conditions have been unfavourable since the 1940s. The decay rates have likely been amplified over the past 50-60 years, and in particular over the most recent decades, due to the combined effect of adverse air temperature and precipitation conditions. Palsa loss is expected to continue, most likely at a higher rate than today, with serious ecological impacts as a consequence.