bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Treatment Failure for Hip and Knee Prosthetic Joint Infections in the Setting of 1- and 2-Stage Exchange Arthroplasty: A Multicenter Retrospective Cohort
Authors: Kandel Christopher E , Jenkinson Richard , Daneman Nick , Backstein David , Hansen Bettina E , Muller Matthew P , Katz Kevin C , Widdifield Jessica , Bogoch Earl , Ward Sarah , Sajja Abhilash , Jeldes Felipe Garcia , McGeer Allison 
Published: October 2019

AbstractBackgroundProsthetic hip and knee joint infections (PJIs) are challenging to eradicate despite prosthesis removal and antibiotic therapy. There is a need to understand risk factors for PJI treatment failure in the setting of prosthesis removal.MethodsA retrospective cohort of individuals who underwent prosthesis removal for a PJI at 5 hospitals in Toronto, Canada, from 2010 to 2014 was created. Treatment failure was defined as recurrent PJI, amputation, death, or chronic antibiotic suppression. Potential risk factors for treatment failure were abstracted by chart review and assessed using a Cox proportional hazards model.ResultsA total of 533 individuals with prosthesis removal were followed for a median (interquartile range) of 814 (235–1530) days. A 1-stage exchange was performed in 19% (103/533), whereas a 2-stage procedure was completed in 88% (377/430). Treatment failure occurred in 24.8% (132/533) at 2 years; 53% (56/105) of recurrent PJIs were caused by a different bacterial species. At 4 years, treatment failure occurred in 36% of 1-stage and 32% of 2-stage procedures (P = .06). Characteristics associated with treatment failure included liver disease (adjusted hazard ratio [aHR], 3.12; 95% confidence interval [CI], 2.09–4.66), the presence of a sinus tract (aHR, 1.53; 95% CI, 1.12–2.10), preceding debridement with prosthesis retention (aHR, 1.68; 95% CI, 1.13–2.51), a 1-stage procedure (aHR, 1.72; 95% CI, 1.28–2.32), and infection due to Gram-negative bacilli (aHR, 1.35; 95% CI, 1.04–1.76).ConclusionsFailure of PJI therapy is common, and risk factors are not easily modified. Improvements in treatment paradigms are needed, along with efforts to reduce orthopedic surgical site infections.
Bone metabolism parameters and inactive matrix Gla protein in patients with obstructive sleep apnea†
Authors: Vilovic Marino , Dogas Zoran , Ticinovic Kurir Tina , Borovac Josip A , Supe-Domic Daniela , Vilovic Tina , Ivkovic Natalija , Rusic Doris , Novak Anela , Bozic Josko 
Published: October 2019

Abstract

Study Objectives
The aim of this study was to investigate differences in dual-energy X-ray absorptiometry (DXA) parameters, trabecular bone score (TBS), bone turnover markers and inactive matrix Gla protein (dp-ucMGP) between patients with obstructive sleep apnea (OSA) and healthy controls.

Methods
This study enrolled 53 male patients diagnosed with OSA, and 50 age- and body mass index (BMI)-matched control subjects. All participants underwent DXA imaging, TBS assessment and blood sampling for biochemical analysis of bone metabolism markers.

Results
Mean apnea–hypopnea index (AHI) score of OSA patients was 43.8 ± 18.8 events/h. OSA patients had significantly higher plasma dp-ucMGP levels in comparison to controls (512.7 ± 71.9 vs. 465.8 ± 50.9 pmol/L, p < 0.001). OSA and control group did not significantly differ regarding standard DXA results, while TBS values were significantly lower in the OSA group (1.24 ± 0.17 vs. 1.36 ± 0.15, p < 0.001). AHI score was a significant independent correlate of plasma dp-ucMGP levels (β ± SE, 1.461 ± 0.45, p = 0.002). In addition, TBS retained a significant relationship with dp-ucMGP values (β ± SE, −93.77 ± 38.1, p = 0.001).

Conclusions
dp-ucMGP levels are significantly higher in patients with OSA and correlate with disease severity. In addition, TBS values in OSA patients are lower in comparison with the control group and decrease with disease severity.
The Bible as a Product of Cultural Power: The Case of Gender Ideology in the English Standard Version
Authors: Perry Samuel L 
Published: October 2019

AbstractSociologists whose research intersects with American Christianity recognize the critical importance of the Bible to understanding many Americans’ beliefs, values, and behaviors, but their operative approach to the Bible generally ignores that “the Bible” is as much a product of interpretive communities as it is a symbolic marker of identity or shaper of social life. I propose that rather than approaching “the Bible” through a distinctly Protestant lens, as given―specifically as uniform, static, and exogenous―sociologists should apply a critical lens to re-conceptualize the Bible more accurately. That is, sociologists should recognize that Bibles are multiform; they are dynamic; and their contents (not just their current interpretations) are highly contingent on temporal culture and power, being the product of manipulation by interpretive communities and actors with vested interests. Using a recent case study of how complementarian gender ideology became systematically inserted into one the most popular English Bible translations among evangelicals today, I illustrate how a more critical approach toward “the Bible” can provide richer, more sophisticated sociological analyses of power and cultural reproduction within Christian traditions.
A new molecular phylogeny-based taxonomy of parasitic barnacles (Crustacea: Cirripedia: Rhizocephala)
Authors: Høeg Jens T , Noever Christoph , Rees David A , Crandall Keith A , Glenner Henrik 
Published: October 2019

AbstractRhizocephalans are abundant members of marine ecosystems and are important regulators of crustacean host populations. Morphological and ecological variation makes them an attractive system for evolutionary studies of advanced parasitism. Such studies have been impeded by a largely formalistic taxonomy, because rhizocephalan morphology offers no characters for a robust phylogenetic analysis. We use DNA sequence data to estimate a new phylogeny for 43 species and use this to develop a revised taxonomy for all Rhizocephala. Our taxonomy accepts 13 new or redefined monophyletic families. The traditional subdivision into the suborders Kentrogonida and Akentrogonida is abandoned, because both are polyphyletic. The three ‘classical’ kentrogonid families are also polyphyletic, including the species-rich Sacculinidae, which is split into a redefined and a new family. Most species of large families remain to be studied based on molecular evidence and are therefore still assigned to their current genus and family by default. We caution against undue generalizations from studies on model species until a more stable species-level taxonomy is also available, which requires more extensive genus- and species-level sampling with molecular tools. We briefly discuss the most promising future studies that will be facilitated by this new phylogeny-based taxonomy.
Phylogeny of the comb-tooth blenny genus Scartella (Blenniiformes: Blenniidae) reveals several cryptic lineages and a trans-Atlantic relationship
Authors: Araujo G S , Vilasboa A , Britto M R , Bernardi G , von der Heyden S , Levy A , Floeter S R 
Published: October 2019

AbstractHere we present the first phylogeny of the genus Scartella based on mitochondrial data. The analysis strongly corroborates the validity of all species of the genus and shows that Scartella cristata, a species with a disjunct distribution, is a lineage complex comprising five clades: two in Caribbean waters, another in the East Atlantic/Mediterranean and two in Brazil. Brazilian clades occur in sympatry from Rio de Janeiro to Rio Grande do Sul states (southern Brazil). One clade (BRA 1) is unique to Brazil, while the other (BRA 2) is closely related to the eastern Atlantic lineage. Possible explanations for this pattern include both natural and anthropic mechanisms.
Papillary thyroid microcarcinoma: optimal management versus overtreatment
Authors: Walgama Evan , Sacks Wendy L. , Ho Allen S. 
Published: October 2019

Purpose of review
The treatment of small, low-risk papillary thyroid carcinoma has undergone a paradigm shift, with many tumors now initially treated with active surveillance rather than upfront surgery. Further studies on patients enrolled in active surveillance have refined our knowledge of the clinical behavior of papillary thyroid microcarcinomas.

Recent findings
This article summarizes the major conclusions of landmark trials that launched active surveillance as a viable treatment option for selected patients. We discuss patient factors such as age and tumor size, the assessment of candidates for active surveillance, barriers to acceptance of active surveillance, quality of life issues, and economic considerations.

Summary
Active Surveillance is a viable first-line treatment option for select papillary microcarcinomas.
Disparities in the Use of Adjuvant External Beam Radiation Therapy in Node-positive Cervical Cancer Patients Following Hysterectomy
Authors: Nasioudis Dimitrios , Musselman Kelsey , Gordhandas Sushmita , Chapman-Davis Eloise , Frey Melissa K. , Caputo Thomas A. , Holcomb Kevin M. 
Published: October 2019

Objective:
The objective of this study was to investigate the use of adjuvant external beam radiation therapy (EBRT) among patients with early-stage cervical carcinoma metastatic to regional lymph nodes (LNs).

Materials and Methods:
The National Cancer Database was accessed and patients with early-stage cervical carcinoma diagnosed between 2004 and 2015 were identified. Those with regional LN metastases who had a hysterectomy were selected and administration of adjuvant EBRT was evaluated. Travel distance from the reporting facility was categorized into short (<12.5 miles), intermediate (12.5 to 49.9 miles) and long (>49.9 miles).

Results:
A total of 3436 patients met the inclusion criteria; the rate of EBRT use was 69.7%. Black women were less likely to receive EBRT compared with white (64.2% vs. 70.6%, P=0.037), while patients who had radical hysterectomy were more likely to receive EBRT compared with those who had simple hysterectomy (72.6% vs. 66%, P<0.001). Rates of EBRT administration for patients who traveled short distance was 74.3% compared with 68.9% and 56.9% for those who traveled intermediate and long distance, respectively (P<0.001). On multivariate analysis, patients who traveled long (odds ratio: 0.44, 95% confidence interval [CI]: 0.36, 0.54) or intermediate (OR: 0.73, 95% CI: 0.61, 0.86) distances were less likely to receive EBRT. After controlling for age, race, insurance, presence of comorbidities, stage, histology, and type of hysterectomy, omission of EBRT was associated with worse survival (hazard ratio: 1.53, 95% CI: 1.32, 1.78).

Conclusions:
A large percentage of patients with early-stage cervical cancer and positive LNs did not receive EBRT following hysterectomy. Black women were less likely to receive EBRT than white women. Travel burden may negatively influence appropriate treatment.
Prognostic Nomogram for Hepatitis B Virus–related Hepatocellular Carcinoma With Adjuvant Transarterial Chemoembolization After Radical Resection
Authors: Huang Jian , Liu Fu-Chen , Li Li , Yuan Sheng-Xian , Yang Yuan , Jiang Bei-Ge , Liu Hui , Pan Ze-Ya 
Published: October 2019

Objectives:
The objective of this study was to establish a reliable and effective nomogram for predicting prognosis of hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC) with postoperative adjuvant transarterial chemoembolization (TACE).

Patients and Methods:
A derivation cohort of 370 HCC patients treated with postoperative TACE in the Eastern Hepatobiliary Surgery Hospital from January 2009 to December 2012 were retrospectively analyzed. Univariate and multivariate analysis were performed by Cox regression and independent prognostic factors for overall survival were determined to construct the nomogram. Concordance index (C-index), calibration curve and decision curve analysis were performed to evaluate the capability of the nomogram and the established nomogram was compared with TNM stage and Barcelona Clinic Liver Cancer (BCLC) stage to identify the superior model. The results were validated in a validation cohort of 123 HCC patients in the same center.

Results:
Multivariate analysis indicated that γ-glutamyl transferase, α-fetoprotein, tumor number, tumor size, satellite lesions, microvascular invasion, and HBV-DNA were independent prognostic factors for overall survival in the derivation cohort, and all these factors were selected into the nomogram. The C-index was 0.755 for survival prediction of the nomogram, which was significantly higher than the TNM stage (0.636, P<0.001) and BCLC stage (0.594, P<0.001). A fair uniformity and a superior net benefit with wide range threshold probabilities were showed in the calibration curves and decision curve analysis. In the validation cohort, the C-index of the nomogram (0.785) also had a higher predictive accuracy than TNM stage (0.744, P=0.019) and BCLC stage (0.616, P<0.001).

Conclusions:
The nomogram with accurate and reasonable performance was proposed for predicting survival of HBV-related HCC with postoperative adjuvant TACE.
Comparison of the effects of two different teaching methods in blood pressure measurement training: a randomized controlled study
Authors: Terzi Banu , Topbaş Eylem , Bingöl Gülay , Mavi Aydoğdu Saadet Gonca 
Published: October 2019

Objective:
To compare the effects of a high-fidelity simulator and conventional teaching model used during blood pressure measurement training on students’ self-confidence, self-efficacy and anxiety levels.

Methods:
A randomized controlled trial design was used. The study was conducted on 59 first-year nursing students of a university in Amasya, Turkey. ‘Self-Confidence Scale,’ ‘general Self-Efficacy Scale’ and ‘Beck Anxiety Scale’ were used to collect the data. A high-fidelity simulator used in blood pressure measurement training was applied to the experimental group, while the conventional method in which the students practice on their peers was applied to the control group. Chi-square, Mann–Whitney U test and the Wilcoxon signed-rank test were used to determine the difference between the two groups’ average.

Results:
No statistically significant difference was found between students’ pre-test and post-test total scores of self-confidence, general self-efficacy and anxiety scales with the high-fidelity simulator and the conventional model (P > 0.05). A significant increase was noted in inner self-confidence and self-efficacy scores of the group working on the high-fidelity simulator (P < 0.05).

Conclusions:
The high-fidelity simulator was effective on the students’ increased levels of self-confidence and self-efficacy, whereas it was not effective on their anxiety levels. However, this study can also be conducted on a larger sample group using a variety of training methods.
Prospective evaluation of 68Ga-DOTANOC positron emission tomography/computed tomography and 131I-meta-iodobenzylguanidine single-photon emission computed tomography/computed tomography in extra-adrenal paragangliomas, including uncommon primary sites and to define their diagnostic roles in current scenario
Authors: Arora Saurabh , Kumar Rakesh , Passah Averilicia , Tripathi Madhavi , Agarwala Sandeep , Khadgawat Rajesh , Bal Chandrasekhar 
Published: October 2019

Aim
To evaluate 68Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) and 131I-meta-iodobenzylguanidine single-photon emission computed tomography/computed tomography (131I-MIBG SPECT/CT) in patients with paragangliomas, including uncommon primaries.

Methods
Ninety patients were prospectively enrolled, and both scans were done within 2 weeks of each other. Lesions were grouped as Head/neck, abdominal, uncommon primary paraganglioma, and metastatic lesions. In most histopathology was used as reference standard.

Results
PET/CT had sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 97%, 94%, 99%,88%,97% respectively on patient wise analysis (90) and 98%, 94%, 99%, 85% and 97% respectively on lesion wise analysis (149). Comparison with MIBG SPECT/CT: Significant difference in sensitivities noted (PET/CT-98%, I-131 MIBG -39%) (P < 0.001), however, no significant difference in specificities (94% and 100%, respectively). Group-wise analysis: Head/Neck: Significant difference noted between PET/CT (sensitivity 100%) and I-131 MIBG SPECT/CT (sensitivity 22%) (P = 0.001). Abdominal: No significant difference noted in sensitivities and specificities of PET/CT and I-131 MIBG SPECT/CT. Uncommon paraganglioma: PET/CT detected 10 of 11, while I-131 MIBG detected only 2 of 11 uncommon paraganglioma. Metastatic sites: Significant difference noted between PET/CT (sensitivity 97%) and I-131 MIBG SPECT/CT (sensitivity 33%) (P < 0.0001).

Conclusion
The study demonstrates high diagnostic accuracy of 68Ga-DOTANOC PET/CT and superiority over 131I MIBG SPECT/CT for evaluation of extra-adrenal paraganglioma. The current diagnostic role of I-131 MIBG seems limited to abdominal paragangliomas and for theranostic purpose.
Mothers' Reasons for Early Breastfeeding Cessation
Authors: Morrison April H. , Gentry Retha , Anderson Joanna 
Published: October 2019

AbstractPurpose:The purpose of this review is to assess maternal explanations for early breastfeeding cessation in economically developed countries.Study Design and Methods:The electromic databases EBSCO, CINAHL, Child Development & Adolescent Studies, PsycInfo, Health Source: Nursing/Academic Edition, Nursing and Allied Health; ProQuest databases: Family Health Database, Health and Medical Collection, Nursing and Allied Health, Psychology Database, and Public Health Databases were searched using the terms breastfeeding, cessation, stop, discontinuation, early weaning, quit∗, early termination, and six months. Inclusion criteria included infants born at least 37 weeks gestation, single birth, and infant birthweight > 2,500 g.Results:Initial literature search yielded 117 studies; 10 studies met inclusion criteria. The two most common reasons for early breastfeeding cessation were perceived inadequate milk supply and maternal breast or nipple pain.Conclusion:Research on maternal reasons for early breastfeeding cessation is limited. Reasons for early breastfeeding cessation are varied; however, the most common themes were perceived inadequate supply and breast or nipple pain. Nurses should tailor assessment of each breastfeeding mother-baby couplet and associated interventions based on these findings.
Perioperative Management in Patients With Cleft Lip and Palate
Authors: Preidl Raimund H.M. , Kesting Marco , Rau Andrea 
Published: October 2019

Abstract
In cleft care, perioperative treatment strategies like ear nose and throat (ENT) diagnostics as well as postoperative antibiotics, feeding, and duration of inpatient stay are nonstandardized procedures varying between different centers. Likewise, intraoperative choice of suture materials and time of suture removal are performed inconsistently. Therefore, we wanted to collect information on protocols focusing on these topics to summarize and subsume currently approved treatment strategies of centers around the world. We ask members of international cleft centers for their respective treatment strategies and performed descriptive statistics.
Absorbable suture material is used for reconstruction of the outer lip skin in 20 of 70 centers. Removal of skin sutures is conducted after 7.0 ± 1.5 days. Suturing of the orbicularis oris muscle, the enoral and nasal mucosa, as well as the palatal musculature is predominantly performed with absorbable suture materials. Intraoperative antibiotic prophylaxis is applied in 82.9% of the participating centers. In contrast, 31.9% of the departments do not apply any antibiotic postoperatively. Postoperative feeding is performed in 27 centers via a nasogastric tube for 4.6 ± 2.3 days on average. Mean length of postoperative inpatient stay is 4.1 ± 2.6 days in children after cleft lip surgery and 4.5 ± 2.7 days after cleft palate surgery. ENT consultation before surgery is routinely conducted in 52.8% of the centers and 82.9% of ENT colleagues investigate middle ear pathologies in the same operation in which cleft repair is performed.
Closure of the lip skin is predominantly performed with nonabsorbable suture material followed by a suture removal after 1 week. Intraoperative antibiotic prophylaxis as well as inpatient hospital stay of 4 to 5 days in combination with oral feeding and a preoperative consultation and intraoperative cooperation with the ENT department seems to be well-proven concepts in cleft lip palate patient care. However, this analysis illustrated the variations and differing approaches in perioperative care emphasizing the need to verify perioperative management concepts in cleft surgery—preferably in the context of multicenter studies.
Locus of Control and Cognition in Older Adults With Type 1 Diabetes
Authors: Eng Chloe W. , Gilsanz Paola , Lacy Mary E. , Beeri Michal Schnaider , Whitmer Rachel A. 
Published: October 2019

Objective:
Life expectancy for individuals with type 1 diabetes mellitus (T1DM) has increased recently; however, it is unknown how diabetes care attitudes affect late-life brain health.

Research Design and Methods:
The Study of Longevity in Diabetes (SOLID) consists of 734 older adults with T1DM, reporting diabetes locus of control (dLOC), age of diabetes diagnosis and other demographics, history of hypoglycemic episodes, and depressive symptoms. Global and domain-specific (language, executive function, episodic memory, simple attention) cognitive functioning was assessed at in-person interviews. Cross-sectional associations between dLOC and cognition were estimated using covariate-adjusted linear regression models in pooled and sex-stratified models.

Results:
In pooled analyses, a 1-point increase in dLOC (more internal) was positively associated with global cognition [β=0.05, 95% confidence interval (CI): 0.02, 0.07], language (β=0.04, 95% CI: 0.01, 0.07), and executive function (β=0.04, 95% CI: 0.01, 0.07), but not episodic memory or simple attention. However, in sex-stratified analyses, this effect was seen only in males and not females.

Conclusions:
In elderly individuals with T1DM, we found associations between dLOC and cognition overall and in men but not women. Underlying sex differences should be considered in future research or interventions on psychosocial characteristics for cognition.