bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of foveal avascular zone measurements in eyes with retinal vein occlusion using optical coherence tomography angiography
Authors: de Oliveira Bruno Mauricio Rodrigues , Nakayama Luis Filipe , de Godoy Bruno Rebello , de Azevedo Alexandre Gomes Bortoloti , Hirai Flavio Eduardo , Mitne Somaia 
Published: August 2020

Abstract
Background
To evaluate the reliability of foveal avascular zone (FAZ) area measurements using optical coherence tomography angiography (OCTA) in eyes with retinal vein occlusion (RVO).

Methods
Twenty-five OCTA exams of patients with RVO were evaluated retrospectively. Three examiners performed manual measurements of the FAZ, and interrater and intrarater reliability were obtained.

Results
The intraclass correlation coefficient (ICC) for interrater reliability for individual measurements was 0.62 (moderate) with a 95% confidence interval (CI) of 0.40 to 0.79 (p < 0.001). The ICC (95% CI) for intrarater reliability was 0.92 (0.82 to 0.96) for rater A, 0.96 (0.91 to 0.98) for B, and 0.88 (0.76 to 0.94) for C (p < 0.001). In all subanalyses including presence of edema and type of occlusion, interrater reliability was poor/moderate, and intrarater reliability was good/excellent.

Conclusion
The FAZ varies significantly among eyes with RVO, so measurements obtained using OCTA should be analyzed with caution due to the moderate level of reliability among different examiners.
The implementation of Small Private Online Courses (SPOC) as a new approach to education
Authors: Ruiz-Palmero Julio , Fernández-Lacorte José-María , Sánchez-Rivas Enrique , Colomo-Magaña Ernesto 
Published: August 2020

SummaryThis article presents a study of the participants of a Small Private Online Course (SPOC) entitled “The Didactic Programming: Elements and Process of Elaboration” at the University of Málaga (Spain). Since the concept was first introduced in 2013, SPOCs have been progressively implemented in higher education. They were conceived to succeed where Massive Open Online Courses (MOOCs) failed, namely in the high drop-out rate. Using a descriptive method, a questionnaire was designed to collect data on the individual characteristics of the University students participating in the SPOC, the degree of satisfaction they expressed at the end of the training process and their opinion regarding class-based courses. The completion rate was 78.7%, and 70.6% of them had previously undertaken online training activities. All the sections of the course (objectives, contents, evaluation, etc.) were favourably evaluated by more than 85% of the participants, as well as their preference for online training.
On innovating: an interview with Gautam Ahuja
Authors: Adbi Arzi , Contigiani Andrea , Szulanski Gabriel , Ahuja Gautam 
Published: August 2020

AbstractAt the 2016 SMS Foundations Session interview with Professor Gautam Ahuja, we explored the key insights of his research trajectory, with a special focus on how organizations successfully innovate. We discussed the major ideas, theories, and results that he and his co-authors generated throughout his successful career. The interview was conducted on September 18, 2016 at the Strategic Management Society Annual Conference in Berlin, Germany. This article discusses Gautam’s role in the organizations’ literature, reports excerpts of the interview, and concludes with a postscript from Gautam Ahuja written for the community of organization design scholars.
Single institutional experience of peripheral applications of a liquid embolic agent: Ethylene Vinyl Alcohol Copolymer
Authors: Salaskar Abhijit L. , Razjouyan Faezeh , Cho Alexander L. , Sood Rishi R. , Akman Andrew , Scher Daniel , Venbrux Anthony C. , Sarin Shawn N. 
Published: August 2020

Abstract
Objective
To evaluate the safety and efficacy of ethylene vinyl alcohol (EVOH) copolymer for the treatment of a variety of peripheral vascular pathologies.

Results
Between October 2010 and October 2017, 43 patients who underwent total 54 EVOH embolization procedures for the treatment of peripheral vascular pathologies were included. The cases which involved the use of EVOH for the treatment of nonvascular, neurologic, ophthalmologic, otolaryngologic or head-neck pathologies were excluded. The demographic data, technical and clinical success rates, and procedure-related details and complications were obtained. The most common indications for EVOH embolization were type II endoleaks (n = 18) and peripheral arteriovenous malformations (n = 14). The majority of cases (62.5%) used EVOH without any adjunct embolic material. The results of this study showed 100% technical success rates and 89% clinical success rates. No events of nontarget embolization or other procedure-related complications were noted. The mortality & morbidity rates were 0%. The loss to follow up rate was 16% (9 /54). The mean follow-up period was 134 days (range, 30 to 522 days).

Conclusion
The single institutional experience supports the safety and efficacy of EVOH embolization in the treatment of various peripheral vascular conditions.
Initial absolute monocyte count as an immune biomarker for clinical response in acute myeloid leukemia with monocytic differentiation
Authors: Embaby Ahmed , Fathy Ayman , Al-Akkad Mohammad , Baraka Ahmad , Ibrahim Taiseer , Zidan Nahla , Refaat Mohamed , Elsheikh Haitham 
Published: August 2020

Abstract
Background
Absolute monocyte count (AMC) correlates with survival outcomes in various hematologic malignancies. However, its role in myeloid malignancies including AML needs to be highlighted. So, this prospective cohort study aimed to assess the effect of AMC on the treatment outcome and survival in a 56 adult de novo AML patients with monocytic differentiation, admitted to the Clinical Hematology Unit, Internal Medicine Department, in a tertiary referral hospital in Egypt, from July 2016 to June 2019.

Results
The initial AMC was measured either by manual differential or the hematology automatic analyzer Sysmex XN-2000 and patients were classified by using receiver operating characteristic curve into two groups monocytopenic (≤ 4 × 109/L) and non-monocytopenic (> 4 × 109/L) group; including 24 (42.9%) and 32 (57.1%) patients, respectively. After a median follow up period of 7.7 (range 0.5–33.2) months, the monocytopenic group was associated with a significantly higher CR rate (P = 0.019), with a lower death as well as relapse and early relapse rates (P = 0.011, 0.033, and 0.002, respectively). Moreover, low initial AMC along with intensive induction were independently associated with complete response to induction chemotherapy with HR, 5.04 [1.37–18.58], P = 0.015, and 5.67 [1.48–21.71], P = 0.011, respectively by using the multivariate logistic regression model. Regarding survival, the monocytopenic group was associated with a better 3-year disease-free survival rate (P = 0.011) in univariate Cox regression only but did not reach significance in the multivariate model and did not affect the overall survival as well.

Conclusion
Initial AMC was found to be an independent prognostic immune biomarker for treatment response in AML patients with monocytic differentiation. However, it did not appear as an independent predictor of survival in a multivariate analysis.

Graphical abstract
Fracture acoustic emission signals identification of stay cables in bridge engineering application using deep transfer learning and wavelet analysis
Authors: Xin Haohui , Cheng Lu , Diender Robin , Veljkovic Milan 
Published: August 2020

AbstractStay cables are typically exposed to the environment and traffic loading leading to degradations due to corrosion and cyclic loading after years’ in service. A non-destructive method to detect the defects of cables as early as possible is needed and important for adequate large-span bridge maintenance. Use of a status-driven acoustic emission (AE) monitoring Convolutional neural network (CNN) method is investigated by combing wavelet analysis and transfer deep learning. CNN is used to construct the relationship between AE signals’ scalograms and cable status. The trained CNN is suitable to identify the in-situ monitored signals and evaluate the current status of cables during the operation of a bridge. As a pilot study, the binary AE signals classification CNN is implemented to identify noise & fracture AE signals in static tests of a stay-cable. Accuracy of the method is investigated. In addition, the trained model is examined using AE signals which are not used in the machine learning to check possible improvements of the accuracy. Expectations in recognition of results and status-driven monitoring potentials are addressed in the paper.
Probiotics for Celiac Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Seiler Caroline L. , Kiflen Michel , Stefanolo Juan Pablo , Bai Julio César , Bercik Premysl , Kelly Ciaran P. , Verdu Elena F. , Moayyedi Paul , Pinto-Sanchez Maria Ines 
Published: August 2020

INTRODUCTION:
Many patients with celiac disease (CD) experience persistent symptoms despite adhering to the gluten-free diet. Different studies have assessed the use of probiotics as an adjuvant treatment for CD. We performed a systematic review and meta-analysis to evaluate the efficacy of probiotics in improving gastrointestinal (GI) symptoms and quality of life (QOL) in patients with CD.

METHODS:
We searched EMBASE, MEDLINE, CINAHL, Web of Science, CENTRAL, and DARE databases up to February 2019 for randomized controlled trials (RCTs) evaluating probiotics compared with placebo for treating CD. We collected data on GI symptoms, QOL, adverse events, serum tumor necrosis factor-α, intestinal permeability, and microbiota composition.

RESULTS:
We screened 2,831 records and found that 7 articles describing 6 RCTs (n = 5,279 participants) were eligible for quantitative analysis. Probiotics improved GI symptoms when assessed by the GI Symptoms Rating Scale (mean difference symptom reduction: 228.7%; 95% confidence interval [CI] 243.96–213.52; P = 0.0002). There was no difference in GI symptoms after probiotics when different questionnaires were pooled. The levels of Bifidobacteria increased after probiotics (mean difference: 0.85 log colony-forming units (CFU) per gram; 95% CI 0.38–1.32 log CFU per gram; P = 0.0003). There were insufficient data on tumor necrosis factor-a levels or QOL for probiotics compared with placebo. No difference in adverse events was observed between probiotics and placebo. The overall certainty of the evidence ranged from very low to low.

DISCUSSION:
Probiotics may improve GI symptoms in patients with CD. High-quality clinical trials are needed to improve the certainty in the evidence (see Visual abstract, Supplementary Digital Content 2, http://links.lww.com/AJG/B595).
The Bowel CLEANsing National Initiative: A Low-Volume Same-Day Polyethylene Glycol (PEG) Preparation vs Low-Volume Split-Dose PEG With Bisacodyl or High-Volume Split-Dose PEG Preparations—A Randomized Controlled Trial
Authors: Barkun Alan N. , Martel Myriam , Epstein Ian L. , Hallé Pierre , Hilsden Robert J. , James Paul D. , Rostom Alaa , Sey Michael , Singh Harminder , Sultanian Richard , Telford Jennifer J. , von Renteln Daniel 
Published: August 2020

INTRODUCTION:
Bowel cleanliness has been shown to be superior with split-dose vs nonsplit preparations; we aimed to directly assess the poorly characterized comparative efficacies of split-dose vs same-day polyethylene glycol (PEG) regimens.

METHODS:
In this study, one of a series of randomized trials performed across 10 Canadian endoscopy units, patients undergoing colonoscopies between 10:30 and 16:30 were allocated to PEG low-volume same-day (15 mg bisacodyl the day before, 2 L the morning of the procedure), low-volume split-dose (15 mg bisacodyl the day before, 1 L + 1 L), or high-volume split-dose (2 L + 2 L). Coprimary endpoints were adequate bowel cleansing based on the Boston Bowel Preparation Scale using in turn different threshold cutoffs.

RESULTS:
Overall, 1,750 subjects were randomized equally across the 3 groups, with no differences in adequate bowel cleanliness rates (low-volume same-day, 90.5%; high-volume split-dose, 92.2%; P = 0.34; and low-volume split-dose, 87.9%; P = 0.17) for the Boston Bowel Preparation Scale ≥6 and 2 for each segment. Willingness to repeat the preparation was not significantly different between low-volume same-day (91.0%) and low-volume split-dose (92.5%; P = 0.40) but was greater than the high-volume split-dose (68.9%; P < 0.01). No significant differences were noted for withdrawal time, cecal intubation, or polyp detection rates.

DISCUSSION:
In this large randomized trial of PEG regimens, low-volume same-day resulted in similar bowel cleanliness compared with high-volume or low-volume split-dosing. Willingness to repeat and tolerability were superior with low-volume same-day compared with high-volume split-dose and similar to low-volume split-dose.
Translumbosacral Neuromodulation Therapy for Fecal Incontinence: A Randomized Frequency Response Trial
Authors: Rao Satish S.C. , Xiang Xuelian , Sharma Amol , Patcharatrakul Tanisa , Yan Yun , Parr Rachael , Ayyala Deepak , Hamdy Shaheen 
Published: August 2020

INTRODUCTION:
Treatments for fecal incontinence (FI) remain unsatisfactory because they do not remedy the underlying multifactorial dysfunction(s) including anorectal neuropathy. The aim of this study was to investigate the optimal dose frequency, clinical effects, and safety of a novel treatment, translumbosacral neuromodulation therapy (TNT), aimed at improving neuropathy.

METHODS:
Patients with FI were randomized to receive 6 sessions of weekly TNT treatments consisting of 600 repetitive magnetic stimulations over each of 2 lumbar and 2 sacral sites with either 1, 5, or 15 Hz frequency. Stool diaries, FI severity indices, anorectal neurophysiology and sensorimotor function, and quality of life were compared. Primary outcome measure was the change in FI episodes/week. Responders were patients with ≥50% decrease in weekly FI episodes.

RESULTS:
Thirty-three patients with FI participated. FI episodes decreased significantly (∆ ±95% confidence interval, 4.2 ± 2.8 (1 Hz); 2 ± 1.7 (5 Hz); 3.4 ± 2.5 (15 Hz); P < 0.02) in all 3 groups when compared with baseline. The 1 Hz group showed a significantly higher (P = 0.04) responder rate (91 ± 9.1%) when compared with the 5 Hz group (36 ± 18.2%) or 15 Hz (55 ± 18.2%); no difference was found between the 5 and 15 Hz groups (P = 0.667). Anal neuropathy, squeeze pressure, and rectal capacity improved significantly only in the 1 Hz (P < 0.05) group compared with baseline, but not in other groups. Quality of life domains improved significantly (P < 0.05) with 1 and 5 Hz groups. No device-related serious adverse events were noted.

DISCUSSION:
TNT significantly improves FI symptoms in the short term, and the 1 Hz frequency was overall better than 5 and 15 Hz. Both anorectal neuropathy and physiology significantly improved, demonstrating mechanistic improvement. TNT is a promising, novel, safe, efficacious, and noninvasive treatment for FI (see Visual Abstract, Supplementary Digital Content 3, http://links.lww.com/AJG/B598).
Effectiveness of Dose De-escalation of Biologic Therapy in Inflammatory Bowel Disease: A Systematic Review
Authors: Little Derek H. W. , Tabatabavakili Sahar , Shaffer Seth R. , Nguyen Geoffrey C. , Weizman Adam V. , Targownik Laura E. 
Published: August 2020

INTRODUCTION:
De-escalation of biologic therapy is a commonly encountered clinical scenario. Although biologic discontinuation has been associated with high rates of relapse, the effectiveness of dose de-escalation is unclear. This review was performed to determine the effectiveness of dose de-escalation of biologic therapy in inflammatory bowel disease.

METHODS:
We searched EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials from inception to October 2019. Randomized controlled trials and observational studies involving dose de-escalation of biologic therapy in adults with inflammatory bowel disease in remission were included. Studies involving biologic discontinuation only and those lacking outcomes after dose de-escalation were excluded. Risk of bias was assessed using the Newcastle-Ottawa Scale.

RESULTS:
We identified 1,537 unique citations with 20 eligible studies after full-text review. A total of 995 patients were included from 18 observational studies (4 prospective and 14 retrospective), 1 nonrandomized controlled trial, and 1 subgroup analysis of a randomized controlled trial. Seven studies included patients with Crohn's disease, 1 included patients with ulcerative colitis, and 12 included both. Overall, clinical relapse occurred in 0%–54% of patients who dose de-escalated biologic therapy (17 studies). The 1-year rate of clinical relapse ranged from 7% to 50% (6 studies). Eighteen studies were considered at high risk of bias, mostly because of the lack of a control group.

DISCUSSION:
Dose de-escalation seems to be associated with high rates of clinical relapse; however, the quality of the evidence was very low. Additional controlled prospective studies are needed to clarify the effectiveness of biologic de-escalation and identify predictors of success.
Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome
Authors: Guilarte Mar , Vicario María , Martínez Cristina , de Torres Inés , Lobo Beatriz , Pigrau Marc , González-Castro Ana , Rodiño-Janeiro Bruno K. , Salvo-Romero Eloísa , Fortea Marina , Pardo-Camacho Cristina , Antolín María , Saperas Esteban , Azpiroz Fernando , Santos Javier , Alonso-Cotoner Carmen 
Published: August 2020

INTRODUCTION:To determine the effect of peripheral CRF on intestinal barrier function in diarrhea-predominant IBS (IBS-D). Irritable bowel syndrome (IBS) pathophysiology has been linked to life stress, epithelial barrier dysfunction, and mast cell activation. Corticotropin-releasing factor (CRF) is a major mediator of stress responses in the gastrointestinal tract, yet its role on IBS mucosal function remains largely unknown.METHODS:Intestinal response to sequential i.v. 5-mL saline solution (placebo) and CRF (100 μg) was evaluated in 21 IBS-D and 17 healthy subjects (HSs). A 20-cm jejunal segment was perfused with an isosmotic solution and effluents collected at baseline, 30 minutes after placebo, and 60 minutes after CRF. We measured water flux, albumin output, tryptase release, stress hormones, cardiovascular and psychological responses, and abdominal pain. A jejunal biopsy was obtained for CRF receptor expression assessment.RESULTS:Water flux did not change after placebo in IBS-D and HS but significantly increased after CRF in IBS-D (P= 0.007). Basal luminal output of albumin was higher in IBS-D and increased further after CRF in IBS-D (P= 0.042). Basal jejunal tryptase release was higher in IBS-D, and CRF significantly increased it in both groups (P= 0.004), the response being higher in IBS-D than in HS (P= 0.0023). Abdominal pain worsened only in IBS-D after CRF and correlated with jejunal tryptase release, water flux, and albumin output. IBS-D displayed jejunal up-regulation of CRF2 and down-regulation of CRF1 compared with HS.DISCUSSION:Stress via CRF-driven mast cell activation seems to be relevant in the pathophysiology of IBS-D.
Mobilidade Internacional Profissional
Authors: Brassolati Gustavo Gasques , Bueno Janaina Maria 
Published: August 2020

O tema mobilidade internacional profissional vem ganhando destaque mundial no que diz respeito às implicações práticas de tal fenômeno, tanto para empresas que buscam alcançar seus objetivos de internacionalização quanto para indivíduos que almejam obter essa experiência profissional. O presente artigo buscou compreender como está a produção acadêmica sobre o tema da mobilidade internacional de profissionais, no campo da Administração, no cenário internacional recente. Para isso, foi realizado um estudo bibliométrico com objetivo de identificar e analisar os artigos sobre mobilidade internacional, em língua inglesa, da área de Administração. De acordo com os critérios utilizados, foram encontrados 39 artigos a partir de busca na base de dados do Portal de Periódicos Capes de 2013 a 2018. A pesquisa possui uma abordagem quantitativa de caráter exploratório e descritivo. Os resultados confirmam as três leis da bibliometria, ou seja, observou-se que há concentração da produção por poucos autores em alguns periódicos e poucas palavras-chave são usadas muitas vezes para descrever o tema e seus subtemas. Identificou-se que o tema está fortemente vinculado à área de Recursos Humanos, em estudos que buscam identificar os fatores de sucesso e fracasso dos processos de mobilidade internacional dos profissionais. A mobilidade internacional é vista como ferramenta estratégica para as empresas alcançarem seus objetivos e melhorias para a organização e seus empregados.
Tradisi Sholawat Mansub Habib Sholeh Bin Muhsin Al-Hamid di Tempeh Tengah, Lumajang
Authors: Mufidah Rizqotul Luqi , Farida Norma Azmi 
Published: August 2020

Living Quran and Hadith studies are increasingly prevalent in Indonesia, the studies increasingly reveals that many traditions of society or groups are based on the Qur’an and hadith. This article focuses on the tradition of reading the sholawat mansub by Habib Sholeh bin Muhsin Al-Hamid in Tempeh Tengah Village, Tempeh District, Lumajang Regency, East Java. Shalawat mansub is a result of the spiritual journey of Habib Sholeh who met with the Prophet Khidir.Then it become a community tradition that was read every night Friday Kliwon 141 times. Then the community perpetuates the recitation of sholawat mansub as a means of tawasul to facilitate all matters. This paper aims to identify phenomenon that use Talal Asad’s theory that Islam as a discursive tradition. This research is a field research about the phenomenon of living hadith. The data used are library sources and interviews that are processed in analytic descriptive. The result of this study are the tradition of reading the blessings of Mansub as a discursive tradition that is accepted and practiced by the people of Central Tempeh, Lumajang. So that the hadiths related to this phenomenon are presentedas a form of text that intermediate human's approach to Allah Swt.
Kritik Ignaz Goldziher dan Pembelaan Musthofa al Azami terhadap Hadis dalam Kitab Shahih al-Bukhari
Authors: Helma Hera Siska 
Published: August 2020

Kritik terhadap kitab hadis akan selalu muncul, walaupun para ulama sudah bersepakat bahwa kitab hadis tersebut shahih, hal ini bisa dilihat dari kitab shahih Imam al-Bukhari, dimana Imam al-Bukhari sudah menyatakan bahwa hadis yang terdapat dalam kitabnya (Shahih al-Bukhari) semua hadisnya shahih, dan itu sudah diakui oleh jumhur ulama akan keshahihan kitab hadis shahih al-Bukhari. Walaupun demikian, juga dapat kritikan dari orientalis yaitu Ignaz Goldziher ia juga termasuk pengkaji hadis yang berasal dari Barat, ia mengatakan bahwa hadis yang terdapat dalam shahih Imam al-Bukhari tidak shahih dan ada hadis palsu didalamnya, kemudian Imam al-Bukhari hanya mengkritik hadis dari segi sanadnya dan tidak pada matannya. Sehingga ia menawarkan dalam membahas hadis harus mengkritik juga matannya dan Ignaz tidak mengakui bahwa hadis yang terdapat dalam kitab shahih Imam al-Bukhari berasal dari Nabi Muhammad SAW melainkan hadis tersebut berasal hanya dari generasi setelah Nabi karena masa pengkodifikasian (pembukuaan) jauh setelah Rasulullah wafat dan hal tersebut dibantah oleh Musthofa al-Azami bahwa tuduhan Ignaz Goldziher terhadap hadis yang ada dalam kitab shahih al-Bukhari tidak valid dijadikan sebagai kebenaran.
Polymorphism and Divergence of Novel Gene Expression Patterns in Drosophila melanogaster
Authors: Cridland Julie M , Majane Alex C , Sheehy Hayley K , Begun David J 
Published: August 2020

Abstract
One mechanism by which transcriptomes evolve is though tissue-specific gene expression. Cridland et al. measured gene expression in Drosophila melanogaster in five tissues: accessory gland, testis, larval salivary gland, head, and first....