bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcome comparison of percutaneous coronary intervention and bypass surgery in diabetic patients with coronary artery disease: a meta-analysis of randomized controlled trials and observational studies
Authors: Zhai ChuanNan , Cong HongLiang , Hou Kai , Hu YueCheng , Zhang JingXia , Zhang YingYi 
Published: December 2019

AbstractBackgroundThe optimal revascularization technique in diabetic patients with complex coronary artery disease (CAD), including left main CAD and multivessel coronary disease (MVD), remains controversial. The current study aimed to compare adverse clinical endpoints of coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) in patients with diabetes mellitus (DM).MethodsRelevant studies were found from MEDLINE, OVID, Science Direct, Embase and the Cochrane Central database from January 2010 to April 2019. Risk ratio (RR) with 95% confidence interval (CI) was used to express the pooled effect on discontinuous variables. Outcomes evaluated were all-cause mortality, major adverse cardiac/cerebrovascular events (MACCE), cardiac death, myocardial infarction, stroke, and repeat revascularization.ResultsSixteen studies were included (18,224 patients). PCI was associated with the increase risk for MACCE (RR 1.59, 95% CI 1.38–1.85), cardiac death (RR 1.76, 95% CI 1.11–2.80), MI (RR 1.98, 95% CI 1.53–2.57), repeat revascularization (RR 2.61, 95% CI 2.08–3.29). The risks for all-cause mortality (RR 1.23, 95% CI 1.00–1.52) and stroke (RR 0.71, 95% CI 0.48–1.03) were similar between two strategies. Stratified analysis based on studies design and duration of follow-up showed largely similar findings with the overall analyses, except for a significant increased risk of all-cause mortality (RR 1.32, 95% CI 1.04–1.67) in long-term group, and CABG was associated with a higher stroke rate compared to PCI, which are results that were found in RCTs (RR 0.47, 95% CI 0.28–0.79) and mid-term groups (RR 0.39, 95% CI 0.23–0.66).ConclusionsCABG was superior to PCI for diabetic patients with complex CAD (including left main CAD and/or MVD), but might be associated with a higher risk of stroke mid-term follow-up.Number of Protocol registrationPROSPERO CRD 42019138505.
Dermatofibrosarcoma protuberans – the use of neoadjuvant imatinib for treatment of an uncommon breast malignancy: a case report
Authors: McGee Matthew W. , Boukhar Sarag A. , Monga Varun , Weigel Ronald , Phadke Sneha D. 
Published: December 2019

Abstract
Background
Dermatofibrosarcoma protuberans is a rare soft tissue malignancy that, if left untreated, can be locally destructive and life-threatening. Dermatofibrosarcoma protuberans is uncommon in the breast, and the similarity of its morphologic features with other spindle cell malignancies can make correct identification difficult. Immunohistochemistry and molecular testing can aid in the correct diagnosis when there is diagnostic uncertainty. Imatinib, a selective tyrosine kinase inhibitor, has been used for adjuvant treatment of dermatofibrosarcoma protuberans following surgical resection. When used as a neoadjuvant treatment, imatinib offers the opportunity to decrease tumor size prior to surgery to lessen the chance for disfigurement.

Case presentation
We present the case of a Caucasian woman who was 46-year-old when she first noted a mass in her right breast in 2015; she was initially diagnosed as having metaplastic breast carcinoma. Mastectomy and systemic chemotherapy were planned; however, after review of pathology at a referral center, the diagnosis was changed to dermatofibrosarcoma protuberans. She was treated with 4 months of neoadjuvant imatinib with adequate tumor shrinkage to perform breast conservation.

Conclusion
This patient’s case stresses the importance of correctly diagnosing this rare breast tumor through the histopathologic appearance of dermatofibrosarcoma protuberans, molecular pathogenesis, and immunohistochemistry. These techniques can help differentiate dermatofibrosarcoma protuberans from metaplastic breast carcinoma and other spindle cell lesions of the breast. This is critical, as the treatment options for metaplastic breast carcinoma significantly differ from treatment options for dermatofibrosarcoma protuberans. This case describes the use of imatinib as a neoadjuvant option to reduce preoperative tumor size and improve surgical outcomes.
Porcine rotavirus mainly infects primary porcine enterocytes at the basolateral surface
Authors: Cui Tingting , Theuns Sebastiaan , Xie Jiexiong , Nauwynck Hans J. 
Published: December 2019

AbstractIntestinal epithelium functions as a barrier to protect multicellular organisms from the outside world. It consists of epithelial cells closely connected by intercellular junctions, selective gates which control paracellular diffusion of solutes, ions and macromolecules across the epithelium and keep out pathogens. Rotavirus is one of the major enteric viruses causing severe diarrhea in humans and animals. It specifically infects the enterocytes on villi of small intestines. The polarity of rotavirus replication in their target enterocytes and the role of intestinal epithelial integrity were examined in the present study. Treatment with EGTA, a drug that chelates calcium and disrupts the intercellular junctions, (i) significantly enhanced the infection of rotavirus in primary enterocytes, (ii) increased the binding of rotavirus to enterocytes, but (iii) considerably blocked internalization of rotavirus. After internalization, rotavirus was resistant to EGTA treatment. To investigate the polarity of rotavirus infection, the primary enterocytes were cultured in a transwell system and infected with rotavirus at either the apical or the basolateral surface. Rotavirus preferentially infected enterocytes at the basolateral surface. Restriction of infection through apical inoculation was overcome by EGTA treatment. Overall, our findings demonstrate that integrity of the intestinal epithelium is crucial in the host’s innate defense against rotavirus infection. In addition, the intercellular receptor is located basolaterally and disruption of intercellular junctions facilitates the binding of rotavirus to their receptor at the basolateral surface.
Hermite–Hadamard type inequalities for co-ordinated convex and qausi-convex functions and their applications
Authors: Latif Muhammad Amer , Rashid Saima , Dragomir Silvestru Sever , Chu Yu-Ming 
Published: December 2019

AbstractIn the article, we present several Hermite–Hadamard type inequalities for the co-ordinated convex and quasi-convex functions and give an application to the product of the moment of two continuous and independent random variables. Our results are generalizations of some earlier results. Additionally, an illustrative example on the probability distribution is given to support our results.
New general decay results for a viscoelastic plate equation with a logarithmic nonlinearity
Authors: Al-Gharabli Mohammad M. 
Published: December 2019

AbstractIn this paper, we investigate the stability of the solutions of a viscoelastic plate equation with a logarithmic nonlinearity. We assume that the relaxation functiongsatisfies the minimal condition$$ g^{\prime }(t)\le -\xi (t) G\bigl(g(t)\bigr), $$g′(t)≤−ξ(t)G(g(t)),whereξandGsatisfy some properties. With this very general assumption on the behavior ofg, we establish explicit and general energy decay results from which we can recover the exponential and polynomial rates when$G(s) = s^{p}$G(s)=spandpcovers the full admissible range$[1, 2)$[1,2). Our new results substantially improve and generalize several earlier related results in the literature such as Gorka (Acta Phys. Pol. 40:59–66, 2009), Hiramatsu et al. (J. Cosmol. Astropart. Phys. 2010(06):008, 2010), Han and Wang (Acta Appl. Math. 110(1):195–207, 2010), Messaoudi and Al-Khulaifi (Appl. Math. Lett. 66:16–22, 2017), Mustafa (Math. Methods Appl. Sci. 41(1):192–204, 2018), and Al-Gharabli et al. (Commun. Pure Appl. Anal. 18(1):159–180, 2019).
Coupled implicit Caputo fractional q-difference systems
Authors: Abbas Saïd , Benchohra Mouffak , Samet Bessem , Zhou Yong 
Published: December 2019

AbstractThis paper deals with some existence, uniqueness, and Ulam stability results for a coupled implicit Caputo fractional q-difference system in Banach and generalized Banach spaces. Some applications are made of some fixed point theorems for the existence and uniqueness of solutions. Next we prove that our problem is generalized Ulam–Hyers–Rassias stable. Some illustrative examples are given in the last section.
New results on Caputo fractional-order neutral differential inclusions without compactness
Authors: Alqudah Manar A. , Ravichandran C. , Abdeljawad Thabet , Valliammal N. 
Published: December 2019

AbstractThis article deals with existence results of Caputo fractional neutral inclusions without compactness in Banach space using weak topology. In fact, for weakly sequentially closed maps we apply fixed point theorems to obtain the existence of the solution. Furthermore, the results are manifested for fractional neutral system held by nonlocal conditions. To justify the application of the reported results an illustration is presented.
In vitro toxic evaluation of two gliptins and their main impurities of synthesis
Authors: Giordani Camila F. A. , Campanharo Sarah , Wingert Nathalie R. , Bueno Lívia M. , Manoel Joanna W. , Costa Barbara , Cattani Shanda , Arbo Marcelo Dutra , Garcia Solange Cristina , Garcia Cássia Virginia , Volpato Nádia Maria , Schapoval Elfrides Eva Scherman , Steppe Martin 
Published: December 2019

Abstract
Background
The presence of impurities in some drugs may compromise the safety and efficacy of the patient’s treatment. Therefore, establishing of the biological safety of the impurities is essential. Diabetic patients are predisposed to tissue damage due to an increased oxidative stress process; and drug impurities may contribute to these toxic effects. In this context, the aim of this work was to study the toxicity, in 3 T3 cells, of the antidiabetic agents sitagliptin, vildagliptin, and their two main impurities of synthesis (S1 and S2; V1 and V2, respectively).

Methods
MTT reduction and neutral red uptake assays were performed in cytotoxicity tests. In addition, DNA damage (measured by comet assay), intracellular free radicals (by DCF), NO production, and mitochondrial membrane potential (ΔψM) were evaluated.

Results
Cytotoxicity was observed for impurity V2. Free radicals generation was found at 1000 μM of sitagliptin and 10 μM of both vildagliptin impurities (V1 and V2). A decrease in NO production was observed for all vildagliptin concentrations. No alterations were observed in ΔψM or DNA damage at the tested concentrations.

Conclusions
This study demonstrated that the presence of impurities might increase the cytotoxicity and oxidative stress of the pharmaceutical formulations at the concentrations studied.
Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
Authors: Jiménez-Vidal Luisa , Espitia-Pérez Pedro , Torres-Ávila José , Ricardo-Caldera Dina , Salcedo-Arteaga Shirley , Galeano-Páez Claudia , Pastor-Sierra Karina , Espitia-Pérez Lyda 
Published: December 2019

AbstractBackgroundNickel and nickel-containing compounds (NCC) are known human carcinogens. However, the precise molecular mechanisms of nickel-induced malignant transformation remain unknown. Proposed mechanisms suggest that nickel and NCC may participate in the dual activation/inactivation of enzymatic pathways involved in cell defenses against oxidative damage, where Nuclear factor-erythroid 2 related factor 2 (Nrf2) plays a central role.MethodsFor assessing the potential role of proteins involved in the Nrf2-mediated response to nickel and NCC exposure, we designed an interactome network using the STITCH search engine version 5.0 and the STRING software 10.0. The major NCC-protein interactome (NCPI) generated was analyzed using the MCODE plugin, version 1.5.1 for the detection of interaction modules or subnetworks. Main centralities of the NCPI were determined with the CentiScape 2.2 plugin of Cytoscape 3.4.0 and main biological processes associated with each cluster were assessed using the BiNGO plugin of Cytoscape 3.4.0.ResultsWater-soluble NiSO4and insoluble Ni3S2were the most connected to proteins involved in the NCPI network. Nfr2 was detected as one of the most relevant proteins in the network, participating in several multifunctional protein complexes in clusters 1, 2, 3 and 5. Ontological analysis of cluster 3 revealed several processes related to unfolded protein response (UPR) and response to endoplasmic reticulum (ER) stress.ConclusionsCellular response to NCC exposure was very comparable, particularly concerning oxidative stress response, inflammation, cell cycle/proliferation, and apoptosis. In this cellular response, Nfr2 was highly centralized and participated in several multifunctional protein complexes, including several related to ER-stress. These results add evidence on the possible Ni2+induced – ER stress mainly associated with insoluble NCC. In this scenario, we also show how protein degradation mediated by ubiquitination seems to play key roles in cellular responses to Ni.
Prosopis juliflora invasion and environmental factors on density of soil seed bank in Afar Region, Northeast Ethiopia
Authors: Shiferaw Wakshum , Bekele Tamrat , Demissew Sebsebe , Aynekulu Ermias 
Published: December 2019

AbstractThe aims of the study were to analyze (1) the effects of Prosopis juliflora (Prosopis) on the spatial distribution and soil seed banks (SSB) diversity and density, (2) the effects of environmental factors on SSB diversity and density (number of seeds in the soil per unit area), and (3) the effects of animal fecal droppings on SSB diversity, density, and dispersal. Aboveground vegetation data were collected from different Prosopis-infested habitats from quadrats (20 × 20 m) in Prosopis thickets, Prosopis + native species stand, non-invaded woodlands, and open grazing lands. In each Prosopis-infested habitats, soil samples were collected from the litter layer and three successive soil layer, i.e., 0–3 cm, 3–6 cm, and 6–9 cm. Seeds from soil samples and animal fecal matter were separated in the green house using the seedling emergence technique. Invasion of Prosopis had significant effects on the soil seed bank diversity. Results revealed that the mean value of the Shannon diversity of non-invaded woodlands was being higher by 19.2%, 18.5%, and 11.0% than Prosopis thickets; Prosopis + native species stand and open grazing lands, respectively. The seed diversity and richness, recovered from 6–9-cm-deep layer were the highest. On the other hand, the density of Prosopis seeds was the highest in the litter layer. About 156 of seeds/kg (92.9%) of seeds were germinated from cattle fecal matter. However, in a small proportion of seedlings, 12 of seeds/kg (7.1%) were germinated from shot fecal matter. Thus, as the seeds in the soil were low in the study areas, in situ and ex situ conservation of original plants and reseeding of persistent grass species such as Cynodon dactylon, Cenchrus ciliaris, Chrysopogon plumulosus, and Brachiaria ramosa are recommended.
Productive performance and meat quality of commercial Cobb chicken fed diets containing different levels of prickly pear fruits (Opuntia ficus indica) peel
Authors: Badr Sherif E. A. , Fattah Mohamed Saleh Abdel , Elsaid Ahmed Salah 
Published: December 2019

Abstract
Background
The objective of this study was to determine the impacts arising from the substitution of prickly pear fruits (Opuntia ficus indica) peels at different levels (0, 5, 10, and 15%) with yellow corn grain in broiler diets and meat quality. In this study, 200 male chick of commercial Cobb breed were used to study the effect of partially replacing of yellow corn grain (YC) with prickly pear fruits peel powder (PPP). Chicks were divided into four treatments (50 birds each), each treatment contained 5 replicates of 10 birds each. The experimental treatments were the following: 1—control diet (R1). 2—diet containing 5% pp (R2). 3—diet containing 10% pp (R3), and 4—diet containing 15% pp (R4). Feeding trails extending to 6 weeks.

Results
Obtained results illustrated that feed intake, live body weight, feed conversion ratio of broiler fed diet containing PPP were better (P < 0.05) than that of control. Broilers fed diet containing 5, 10, and 15% PPP were heavier (P < 0.05) by 1.60, 3.68, and 5.78%, respectively, over those fed the control diet. Inoculation of diets containing PPP achieved high (P < 0.05) carcasses weight and dressing% compared with control. Significant differences (P < 0.05) were detected for serum total protein, and total globulin of blood serum broiler as feeding inclusion levels of tested diets. Broiler fed diets contained 15% achieved higher degrees of taste, color, odor (aroma), texture, and overall acceptability. Highest (P < 0.05) biological value, true-digestibility and net protein utilization of broiler meat-fed PPP than other groups of control which was expected, as casein is a protein source with optimal digestibility.

Conclusions
It could be concluded that feeding commercial Cobb chicken on diets containing 15% prickly pear peel (Opuntia ficus indica) peel substituted with yellow corn grain, resulted in superior nutrition status and better daily gain, feed conversion ratio, economical efficiency, and better meat quality, as compared with other groups could be recommended.
Impact of Nonadsorbed Ionomer on Viscosity of Catalyst Inks for Polymer Electrolyte Fuel Cells
Authors: Yoshimune Wataru , Harada Masashi 
Published: December 2019

Abstract
In a catalyst ink for polymer electrolyte fuel cells (PEFCs), some of the ionomer is adsorbed on the carbon-supported Pt catalyst (Pt/C), which enhances the ink stability, while the rest is dispersed in the solvent as a nonadsorbed ionomer. To clarify the effect of nonadsorbed ionomer on the ink viscosity, the amount of nonadsorbed ionomer in the catalyst ink was evaluated by small-angle neutron scattering (CV-SANS). At high-shear viscosity, the nonadsorbed ionomer was found to act as ionomer solution described by the Huggins equation. Moreover, comparison with the CV-SANS results revealed that the conventional filtration method overestimates the amount of nonadsorbed ionomer in a catalyst ink.
Using the Force of Representation
Authors: Walker Casey 
Published: December 2019

This paper explores how the most recent Star Wars films released after Disney's acquisition of Lucasfilm, Episode VII: The Force Awakens and Episode VIII: The Last Jedi, serve as a fertile discursive space for the growing anxieties over the rise of the white nationalist movement in the United States over the last decade. Unlike previous Star Wars trilogies, Episodes VII and VIII foreground the "Other" in juxtaposition to the whiteness that the Empire and First Order represent both figuratively and literally. By incorporating a more diverse array of characters, such as people of color, women, and immigrants, the Resistance is juxtaposed against the mostly white, mostly male First Order in these films. This has led to the First Order being read by many as a symbol of the white nationalism movement, as it strives to maintain its own perceived superiority over the resistance of "Others."
A diagnostic dilemma: a firm left submandibular node
Authors: Shabir Aisha , Halai Tina , Eyeson Josiah 
Published: December 2019

A diagnostic conundrum of a firm, left submandibular node presenting in a 35-year-old female with a history of pain and persistent swelling is described. This paper aims to educate readers on the differential diagnostic dilemma that may be faced in general practice and discusses the importance of shared care in a multidisciplinary setting. CPD/Clinical Relevance: The presentation of this clinical case is discussed with radiographic imaging and the multidisciplinary approach undertaken for patient management. Readers can identify the steps undertaken in this case to exclude conditions in the surgical sieve.
‘We need a physician who is a human being too’: exploration of barriers and facilitators for hospitalised palliative patients and their families to discuss advance care planning
Authors: Vanderhaeghen Birgit , Bossuyt Inge , De Nys Katelijne , Menten Johan , Rober Peter 
Published: December 2019

Background:Advance care planning (ACP) is not well implemented in hospital. Implementation theory stresses the importance of knowing what hospitalised palliative patients and their families experience as barriers or as facilitators in the uptake of ACP with their treating physician.Aims:This study aimed to gain an in-depth understanding of what hospitalised palliative patients and their families experienced as barriers or facilitators for having ACP conversations.Methods:We used a tape-assisted recall procedure to conduct 29 videotaped interviews with hospitalised patients and their families. We used content analysis based on grounded theory principles.Results:Four major fields of tension were discovered: not knowing what to expect from the treating physician; not being sure the treating physician can be a trusted partner; daring to speak about ACP; and staying loyal to one's own wishes.Conclusions:Patients and families need physicians who are accessible and can be trusted ACP partners throughout the disease process.
Spirituality-focused end-of-life care among paediatric patients: evidence from Saudi Arabia?
Authors: Khraisat Omar MA , Alkhawaldeh Abdullah , Abuhammad Sawsan 
Published: December 2019

Background: Spirituality has been recognised as an essential aspect of patient care. Aim: To assess the greatest facilitators that would help to provide spirituality for paediatric end of life. Methods: Two hundred and fifty oncology nurses were surveyed using a spirituality and spiritual care rating questionnaire. Findings: The greatest facilitators perceived by nurses were: believe in spirituality as a unifying force that enables one to be at peace with oneself and the world; listening and allowing patients time to discuss and explore their fears; and using art, creativity and self-expression; respect for privacy, dignity and religious and cultural beliefs of a patient. Conclusions: Many nursing-related facilitators to spirituality care were found. They need to be addressed and supported through education and training.
Multiphoton absorption in type-II InAs/GaSb superlattice structure
Authors: Zhao Chengcheng , Huang Jianliang , Nie Biying , Zhang Jinchuan , Zhang Yanhua , Ma Wenquan 
Published: December 2019

We report on multiphoton absorption (MPA) of a type-II superlattice (T2SL) infrared photodetector using InAs/GaSb materials. At 87 K, the 100% cutoff wavelength of the detector response is 3.4 µm for linear absorption; however, we have observed degenerate two and higher MPA using a quantum cascade laser (

λ
=
4.6

µ

m

) as the excitation source. The observed photocurrent responses are designated as due to two-photon, five-photon, and 11-photon absorption for different incident laser power ranges. Considering the wide detection wavelength range covered, which extends from 1 to 30 µm, this result may demonstrate unlimited potential for research and applications based on MPA using InAs/GaSb T2SL materials.