bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID‐19 pandemic on mental health of patients with inherited bleeding disorders in Germany
Authors: von Mackensen Sylvia , Halimeh Susan , Siebert Manuela , Wermes Cornelia , Hassenpflug Wolf , Holstein Katharina , Olivieri Martin 
Published: September 2020

AbstractBackgroundThe worldwide pandemic spread of SARS‐CoV‐2 can lead to either respiratory infection or containment‐associated isolation with possible higher impact on chronic diseases such as inherited bleeding disorders (IBD). The aim of the study was to evaluate the impact of COVID‐19 on patients and caregivers of IBD patients regarding their concerns and worries related to own health, access to treatment and availability of factor concentrates and their experiences related to medical care.MethodsMulticentre, cross‐sectional study evaluating the impact of COVID‐19 on mental health of IBD patients. An ad hoc questionnaire was developed and sent to 586 patients/caregivers with haemophilia A, haemophilia B and VWD type III. The survey included information on demographic and clinical data, needs, concerns and experiences regarding medical care during COVID‐19 pandemic.ResultsIn total, 355 of the IBD‐Group (200 patients, 155 caregivers) completed the survey (61.7% response rate). Most patients suffered from haemophilia A (73.8%) and were severely affected (64.7%). Eleven patients were in quarantine due to suspected COVID‐19; none had symptoms. One quarter worried (very) strongly about getting the coronavirus, 71.3% asked themselves what will happen to them when they will get COVID‐19, 40.1% felt unchanged, and 18.9% worried about delivery difficulties of their IBD treatment product. In 52.8%, medical appointments were postponed. Significant differences between caregivers and patients were found in most aspects.DiscussionThe IBD patients affected by a chronic disorder have particular thoughts and worries regarding COVID‐19. Haemophilia specialists should be committed to address these concerns and guarantee treatment despite containment strategies.
Review: Prevention and management of gastric cancer
Authors: Venerito Marino , Ford Alexander C. , Rokkas Theodoros , Malfertheiner Peter 
Published: September 2020

AbstractGastric cancer (GC) is still the fifth most frequently diagnosed cancer and the third leading cause of cancer deaths in both sexes worldwide. Although the incidence of GC is predicted to continue declining in a growing number of countries in the future, on a global scale the number of newly diagnosed GC cases will remain high, or increase even further, due to changes in population size and increasing risks observed in younger generations. In a retrospective cohort study, collecting data from the Veterans Health Administration, treatment of Helicobacter pylori infection decreased GC risk only if eradication was successful. In a German case‐control study, among GC patients with autoimmune gastritis, pernicious anemia was associated with earlier detection of GC, which translated into a significantly better 5‐year survival. In an updated meta‐analysis, H. pylori eradication therapy in healthy individuals significantly reduced both GC incidence and mortality from GC with a number needed to treat of 72 and 135, respectively. In Korea, successful H. pylori eradication substantially reduced GC incidence in first‐degree relatives of GC patients as well. A meta‐analysis of four trials including 1,556 patients with resectable GC reported that the patient subgroup tumors with high microsatellite instability undergoing surgery did not benefit from perioperative or adjuvant chemotherapy.
MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics
Authors: Taverna Cecilia , Baněčková Martina , Lorenzon Monica , Palomba Annarita , Franchi Alessandro , Skalova Alena , Agaimy Abbas 
Published: September 2020

AimsSecretory carcinoma (SC) (synonym: mammary analogue secretory carcinoma) is a low‐grade salivary gland tumour that occurs in both major and minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, which overlaps with those of several salivary gland neoplasms, including acinic cell carcinoma (AciCC) and intercalated duct‐type intraductal carcinoma (IDC) in major salivary glands, and polymorphous adenocarcinoma (PAC) in minor salivary glands. These tumours share with SC some morphological features and SOX10 immunoreactivity; also, with the exception of AciCC, they all coexpress S100 and mammaglobin.Methods and resultsWe compared MUC4 and mammaglobin expression in 125 salivary gland carcinomas (54 genetically confirmed SCs, 20 AciCCs, 21 PACs, and 30 IDCs) to evaluate the potential of these two markers to differentiate these entities. Moderate to strong diffuse MUC4 positivity was detected in 49 SCs (90.7%), as compared with none of the IDCs and PACs. In contrast, mammaglobin was frequently expressed in SCs (30 of 36 cases; 83.3%), IDCs (24/28; 85.7%), and PACs (7/19; 36.8%). Two of three high‐grade SCs lost MUC4 expression in the high‐grade tumour component. No significant correlation was found between MUC4 expression and the fusion variant in SC (ETV6–NTRK versus non‐ETV6–NTRK).ConclusionThe results of our study identify MUC4 as a sensitive (90.7%) and specific (100%) marker for SC, with high positive (100%) and negative (93.4%) predictive values. Thus, MUC4 may be used as a surrogate for SC in limited biopsy material and in cases with equivocal morphology.
The Transplanted Appropriate Adult Scheme in China
Authors: MOU YU 
Published: September 2020

AbstractBorrowed from England and Wales, the Chinese Appropriate Adult Scheme involves a dynamic of selective adaptation. This article analyses two salient features of the appropriate adult scheme within the Chinese context, in comparison with its counterpart in England and Wales: its complementarity of the juvenile's parent, and the passive role that appropriate adults play during pretrial interrogations. Drawing upon empirical evidence, the article argues that the transplanted Chinese appropriate adult scheme has failed to oversee the legality of interrogations, nor does it provide adequate safeguards for juvenile suspects. The concept of vulnerability that lies at the heart of the appropriate adult safeguard in England and Wales appears to be lost in translation. Rather than providing a safeguard for juveniles at their most vulnerable, the appropriate adult is more concerned with indulging the needs of the interrogators in China.
Changes in the eye contour signs due to age among Mexican women: Comparison with women of other ethnic origins
Authors: Flament F. , Coubard O. , Cruz R. , Flores F. 
Published: September 2020

AbstractObjectiveTo evaluate the changes in certain ocular signs because of age, among Mexican women and to compare these with those previously obtained on women of other ethnicities.Material and methodsPhotographs were taken of the faces of 203 Mexican women of different ages, under standardized conditions. These photographs allowed us to focus and define nine ocular signs, which were then graded by 15 experts and dermatologists, using standardized scales provided by a reference Skin Aging Atlas. Hence, the same protocol, previously used on 3240 women of four other ethnic origins (Caucasian: 600; Chinese: 990; Japanese: 1010; Indian: 300; African: 340), allowed us to compare the results obtained on Mexican women.ResultsThe severity of crow’s feet wrinkles for Mexican women shows a more intense progression with age than those of women from other ancestries. The lower eyelid wrinkles of Mexican women, that show weak or erratic changes with time, were however found to have higher and significant severity at a young age. Pigmentation disorders of their ocular area were found less pronounced as compared to those of Asian or Indian women. Eye bags were observed with similar slight changes in all five ancestries.ConclusionThe present work confirms that the clinical signs of age for the female eye area develop differently depending on the ethnic origins of the volunteer.
Green approach towards hydrolysing wheat gluten using waste ingredients from pineapple processing industries
Authors: Banerjee Shivali , Ranganathan Vijayaraghavan , Arora Amit , Patti Antonio F. 
Published: September 2020

SummaryIn this work, wheat gluten was hydrolysed with pineapple crude extract, obtained from pineapple core which is a waste from the pineapple processing industry. The efficacy of crude pineapple extract was at par with the commercial bromelain in terms of hydrolysing wheat gluten. The hydrolysis proceeded at a rapid rate during the first 60 min, then slowed down till 120 min, followed by a further steep rise until 180 min and a very slow reaction up to the 24‐h incubation period. The resulting hydrolysates had a fair solubility (>40%) over a pH range of 2–10. The molecular masses of the identified mixture of peptides ranged between 500 and 5000 Da, with 16% and 79% of the identified peptides in the range 0.5–1.0 and 1.0–2.0 kDa, respectively. The functional properties of the hydrolysates were remarkably better than the original gluten.
The biological characters of Bmelav‐like genes in the development of Bombyx mori
Authors: Sun X. , Zhang K. , Gu J. , Yang J. , Huang Q. , Yan R. , Qin S. , Hou C. , Zhang G. , Wang S. , Li M. 
Published: September 2020

AbstractThe ELAV/Hu family is a conserved multigene family of pan‐neuronal RNA‐binding protein involved in post‐transcriptional regulation in metazoans. In Drosophila, three members of this family, ELAV, RBP9 and FNE, are involved in neuronal differentiation, gene expression regulation and so on. This family is less well characterized in Bombyx mori. Two orthologs BmELAV‐like‐1 (BmEL‐1) and BmELAV‐like‐2 (BmEL‐2) share 55%–71% and 47%–62% identity with that of in Drosophila and humans, respectively. Bmel‐1 is ubiquitously expressed while Bmel‐2 is expressed in the head and ovaries specifically. Proteins encoded by both genes are localized in nuclear and cytoplasm. The weight of body, cocoon, pupae and cocoon shell are differently affected in Bmel‐1−/−2− mutants created using CRISPR/Cas9 technology. Mutations of both genes increase the expression of four silk protein genes, Fib‐L, Fib‐H, P25 and Ser‐1. In addition, the oviposition ability of Bmel‐2− females is decreased. This study not only provides valuable insights into the functional roles of Bmelav‐like genes in the growth, cocoon characters and regulation of silk protein genes expression, but also provides useful information for silkworm variety breeding.
Arbitration of accommodation in US workplaces: employee, stakeholder and human resources characteristics
Authors: Zilic Ivana , LaVan Helen 
Published: September 2020

AbstractThis research examines how arbitrators consider accommodations for employees with physical and mental illnesses. Unlike other recent research on the subject, the authors specifically and purposely draw their sample from recent US arbitration cases—2015 to 2018, n = 209. Additionally, using content analysis software, NVivo, the case characteristics were autocoded, and the case outcomes were manually coded. Using logistic regression, the following model was developed to predict the odds of case outcomes: disability, injury, discrimination, retaliation, absence and reinstatement. The Cox and Snell and Nagelkerke analysis indicates that our model accounts for approximately 15.6 to 21.5 per cent of the variance, with 33.3 per cent of the individual and split arbitration cases outcomes and 91.2 per cent for organisation arbitration cases correctly predicted. The model predicts 71.2 per cent of the cases.
Small RNA sequencing reveals a novel tsRNA‐06018 playing an important role during adipogenic differentiation of hMSCs
Authors: Wang Tao , Cao Lingling , He Shan , Long Kai , Wang Xinping , Yu Hui , Ma Baicheng , Xu Xiaoyuan , Li Weidong 
Published: September 2020

AbstractTransfer RNA‐derived small RNAs (tsRNAs), a novel type of non‐coding RNA derivative, are able to regulate a wide range of biological processes. What role these tsRNAs play in the regulation of human bone marrow mesenchymal stem cell (hMSCs) adipogenic differentiation remains uncertain. We induced the adipogenic differentiation of human bone marrow mesenchymal cells (hMSCs) and then performed small RNA transcriptomic sequencing, leading us to identify tsRNA‐06018 as a target of interest based upon resultant the tsRNA expression profiles. When tsRNA‐06018 was knocked down, this led to the inhibition of adipogenesis and a decrease in adipogenic marker expression. When STC2 was overexpressed, this impaired the adipogenic differentiation of these cells. We further used luciferase reporter assays to confirm that tsRNA‐06018 directly binds the 3′‐untranslated region (3′‐UTR) of STC2. In addition, we determined that both knocking down tsRNA‐06018 and overexpressing STC2 increased extracellular signal‐regulated kinase 1/2 (ERK1/2) phosphorylation within cells. We also assessed that the adipogenic differentiation of hMSCs in which tsRNA‐06018 was knocked down was further enhanced upon the addition of the ERK1/2 inhibitor U0126 as compared tsRNA‐06018 knockdown alone. Taken together, using small RNA sequencing we profiled tsRNAs in hMSCs during the process of adipogenesis, leading us to identify tsRNA‐06018 as a novel regulator of this differentiation process. This tsRNA was able to regulate adipogenic differentiation by targeting STC2 via the ERK1/2 signalling pathway.
Stress distribution within the ceramic veneer‐tooth system with butt joint and feathered edge incisal preparation designs
Authors: Chai Sy Yin , Bennani Vincent , Aarts John M. , Lyons Karl , Das Raj 
Published: September 2020

AbstractObjectiveThis in‐vitro study aims to study the stress distribution within the ceramic veneer‐tooth system with two incisal preparation designs—butt joint (BJ) and feathered edge (FE), and to correlate these findings to the results of our previous published load‐to‐failure study.MethodsSix photoelastic models were fabricated with an epoxy resin material (West System 105 Epoxy Resin/205 Fast Hardener, West System) to represent BJ and FE preparation configurations at 0° and 20° loading angulations. Lithium disilicate ceramic veneers (IPS e.max CAD, Ivoclar Vivadent) were bonded to the BJ and FE photoelastic models using resin cement (IPS Variolink Esthetic, Ivoclar Vivadent). Each model was loaded using an Instron Universal Testing Machine at the incisal edge at a cross‐head speed of 0.25 mm/min till 100 N.ResultsBJ photoelastic model had more uniform distribution compared with FE photoelastic models under 0° and 20° loading angulations.ConclusionParallel to the results of our earlier load‐to‐failure published study, both incisal preparation designs affect stress distribution within the ceramic veneer‐tooth system. BJ photoelastic model demonstrated a more uniform distribution compared with FE photoelastic model.Clinical SignificanceBJ incisal preparation design has more uniform stress distribution than FE preparation design within the ceramic veneer‐tooth system.
Engineering properties of dried ash gourd (Benincasa hispidaCogn) seeds: Mass modeling and its analysis
Authors: Gade Sanghmitra R. , Meghwal Murlidhar , Prabhakar Pramod K. 
Published: September 2020

AbstractThe correlation of engineering properties and mass of ash gourd seeds was explored by using models like linear, quadratic, S‐curve, power, and multivariate. The recorded range of values for seed groups (group of large mass, medium mass, and small mass) was 92.77 to 34.07 g for thousand seed mass, 28.06 to 24.46 for angle of repose, 5.64 to 4.90 m/s for terminal velocity, 213.73 to 227.12 N/mm for hardness. Coefficient of static friction was found the highest for rubber (0.488) and the lowest for aluminum (0.305) for all sizes of seeds. The recommended models based on dimensions were linear, quadratic, and power models withR2= 0.997 based on arithmetic mean diameter for large mass seeds, power model (R2= 0.999) based on geometric mean diameter for medium mass seeds, quadratic and power models with sameR2= 0.999 based on arithmetic mean diameter for small mass seeds. The recommended area‐based models for large mass, medium mass, and small mass seeds were quadratic model (R2= 0.997) based on projected areas perpendicular to length, power model (R2= 0.999) based on projected areas perpendicular to thickness, and quadratic model (R2= 0.999) based on projected area's perpendicular thickness, respectively. For surface area‐based models, quadratic model (R2= 0.997) for group of large mass, quadratic and power models (R2= 0.999) for group of medium mass, and quadratic model (R2= 0.999) for group of small mass were found to be acceptable. Models based on ellipsoid volume of seed were recommended for all groups. The properties studied and models explored (best fitted) may be used for process and equipment design.Practical ApplicationsAsh gourd seeds are discarded as waste by ash gourd processing food industries (mainlyPethaindustries in the northern part of India). Seeds are rich in proteins, minerals and oil, the ash gourd seed oil is high in therapeutic value, as it is rich in phytonutrients such as vitamins (A and E), squalene, terpenoids, and alkaloids. Seeds are also rich in antibacterial and antifungal properties. This makes it highly valuable for food, pharmaceutical, and cosmetic industries. The size of seed changes as the size of fruit changes and physical properties of seed depend on seed size. This study will give the knowledge of the properties of seeds, which help to design equipment for processing of seeds for various end products with the best quality. The explored models may be used for prediction of mass as per the size of seeds and help in understanding the processing operations.
Effect of Ultraviolet irradiation on the stilbenoid content of blueberry leaves
Authors: Kim Tae‐Eun , Pyee Jae‐Ho , Cho Yong‐Jin 
Published: September 2020

AbstractThe stilbenoid content in various parts of blueberry plants and the effect of ultraviolet (UV) treatment on the stilbenoid content in blueberry leaves were investigated. Stilbenoid content was determined by HPLC analysis; the results showed significant differences in various parts of the plant. The leaves had the highest content of t‐resveratrol and t‐pinosylvin, 2.43 and 0.09 μg/g dry weight, respectively. The leaves and pericarp had higher amounts of t‐pterostilbene than the stem, and their values were 0.11 and 0.14 μg/g dry weight, respectively. In order to enrich the stilbenoid content in the leaves, UV irradiation was performed on freshly collected leaves. After UV irradiation, the content of t‐resveratrol and t‐pterostilbene were significantly enriched; 3.1 and 1.5 times by UV‐A, and 1.2 and 1.5 times by UV‐C, respectively. Consequently, leaves treated with UV‐A or UV‐C may potentially be utilized as a good source of health‐functional materials.Practical applicationsDespite the various functionalities and applications of stilbenoids, high costs are involved in its commercial production, due to its low content in blueberries. The results of this study can highlight strategies for cost reduction during processing. UV treatment is a simple method of physical processing, which may be used without causing contamination of the product.
Thiol‐disulfide status of patients with cervical cancer
Authors: Sezgin Burak , Kinci Mehmet F. , Pirinççi Fatih , Camuzcuoğlu Aysun , Erel Özcan , Neşelioğlu Salim , Camuzcuoğlu Hakan 
Published: September 2020

AbstractAimThe evaluation of dynamic thiol‐disulfide homeostasis among patients with the cancer of the uterine cervix.MethodsThe study was conducted in 62 cervical cancer patients and 61 healthy women who had been followed up in an obstetrics and gynecology clinic between September 2018 and April 2020. Serum disulfide, native thiol, total thiol, ischemia modified‐albumin, total antioxidant and oxidant capacities, and oxidative stress index values were measured in all participants.ResultsThe mean plasma disulfide levels of the cervical cancer group was statistically significantly higher than that of the control group (25.79 ± 6.90 μmol/L, 22.31 ± 6.11 μmol/L, respectively) (P = 0.004). Plasma native thiol and total thiol levels were lower in cervical cancer patients (299.27 ± 99.05 μmol/L and 350.86 ± 102.72 μmol/L, respectively) compared to controls, but no statistically significant difference was observed (318.00 ± 93.75 μmol/L and 376.44 ± 98.51 μmol/L, respectively) (P = 0.284, P = 0.161). With respect to the ischemia modified‐albumin level, no statistically significant difference was observed between two groups. There were statistically significant positive association between disulfide level and both the stage of cervical cancer (r = 0.278, P = 0.029) and total oxidant capacity level (r = 0.256, P = 0.046).ConclusionDynamic thiol‐disulfide homeostasis may participate in the pathophysiological mechanisms of cervical cancer and may be a potential biomarker for early identification of cervical cancer in future.
Melatonin promotes regeneration of injured motor axons via MT1 receptors
Authors: Stazi Marco , Negro Samuele , Megighian Aram , D'Este Giorgia , Solimena Michele , Jockers Ralf , Lista Florigio , Montecucco Cesare , Rigoni Michela 
Published: September 2020

AbstractMelatonin is an ancient multi‐tasking molecule produced by the pineal gland and by several extrapineal tissues. A variety of activities has been ascribed to this hormone in different physiological and pathological contexts, but little is known about its role in peripheral neuroregeneration. Here, we have exploited two different types of injury to test the capability of melatonin to stimulate regeneration of motor axons: (a) the acute and reversible presynaptic degeneration induced by the spider neurotoxin α‐Latrotoxin and (b) the compression/transection of the sciatic nerve. We found that in both cases melatonin administration accelerates the process of nerve repair. This pro‐regenerative action is MT1‐mediated, and at least in part due to a sustained activation of the ERK1/2 pathway. These findings reveal a receptor‐mediated, pro‐regenerative action of melatonin in vivo that holds important clinical implications, as it posits melatonin as a safe candidate molecule for the treatment of a number of peripheral neurodegenerative conditions.
Development of the Japanese Version of the Achievement Emotions Questionnaire – Elementary School (AEQ‐ES‐J)1,2
Authors: Suzuki Masayuki , Tonegawa Akiko 
Published: September 2020

AbstractThe purpose of this study was to develop and validate a Japanese version of the Achievement Emotions Questionnaire – Elementary School (AEQ‐ES), which assesses enjoyment, anxiety, and boredom experienced by elementary school students within the settings of attending class, doing homework, and taking tests. Japanese elementary school students (n = 863 for the first survey; n = 332 for the second survey) participated in the questionnaire survey. The results showed that the psychometric properties of the Japanese AEQ‐ES were comparable to those of the original version. Moreover, the results showed that students' achievement emotions were associated with their control and value appraisals, as well as their academic motivation, learning strategies, academic performance, and support from teachers. These results indicated that the Japanese version of the AEQ‐ES was a good measure of elementary school students' emotions and supported the propositions of the control–value theory of achievement emotions.