bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Energy Expenditure and Step Count Measured by ActiGraph Accelerometers Among Dominant and Nondominant Wrist and Hip Sites
Authors: Nuss Kayla J. , Hulett Nicholas A. , Erickson Alden , Burton Eric , Carr Kyle , Mooney Lauren , Anderson Jacob , Comstock Ashley , Schlemer Ethan J. , Archambault Lucas J. , Li Kaigang 
Published: November 2020

Objective: To validate and compare the accuracy of energy expenditure (EE) and step counts measured by ActiGraph accelerometers (ACT) at dominant and nondominant wrist and hip sites. Methods: Thirty young adults (15 females, age 22.93 ± 3.30 years) wore four ActiGraph wGT3X accelerometers while walking and running on a treadmill for 7 min at seven different speeds (1.7, 2.5, 3.4, 4.2, 5.0, 5.5, and 6.0 mph). The EE from each ACT was calculated using the Freedson Adult equation, and the “worn on the wrist” option was selected for the wrist data. Indirect calorimetry and manually counted steps were used as criterion measures. Mean absolute percentage error and two one-sided test procedures for equivalence were used for the analyses. Results: All ACTs underestimated the EE with mean absolute percentage errors over 30% for wrist placement and over 20% for hip placement. The wrist-worn ACTs underestimated the step count with mean absolute percentage errors above 30% for both dominant and nondominant placements. The hip-worn ACTs accurately assessed steps for the whole sample and for women and men (p < .001 to .05 for two one-sided tests procedures), but not at speeds slower than 2.0 mph. Conclusion: Neither hip nor wrist placements assess EE accurately. More algorithms and methods to derive EE estimates from wrist-worn ACTs must be developed and validated. For step counts, both dominant and nondominant hip placements, but not wrist placements, lead to accurate results for both men and women.
Sedimentary and volcanic record of the nascent Izu-Bonin-Mariana arc from IODP Site U1438
Authors: Waldman Ryan J. , Marsaglia Kathleen M. , Hickey-Vargas Rosemary , Ishizuka Osamu , Johnson Kyle E. , McCarthy Anders , Yogodzinski Gene , Samajpati Eshita , Li He , Laxton Kate , Savov Ivan P. , Meffre Sebastien , Arculus Richard J. , Bandini Alexandre N. , Barth Andrew P. , Bogus Kara , Brandl Philipp A. , Gurnis Michael , Jiang Fuqing 
Published: November 2020

Abstract
The oldest known, intact sedimentary record of a nascent intraoceanic arc was recovered in a ∼100-m-thick unit (IV) above ca. 49 Ma basaltic basement at International Ocean Discovery Program Site U1438 in the Amami Sankaku Basin. During deposition of Unit IV the site was located ∼250 km from the plate edge, where Izu-Bonin-Mariana subduction initiated at 52 Ma. Basement basalts are overlain by a mudstone-dominated subunit (IVC) with a thin basal layer of dark brown metalliferous mudstone followed by mudstone with sparse, graded laminae of amphibole- and biotite-bearing tuffaceous sandstone and siltstone. Amphibole and zircon ages from these laminae suggest that the intermediate subduction-related magmatism that sourced them initiated at ca. 47 Ma soon after basement formation. Overlying volcaniclastic, sandy, gravity-flow deposits (subunit IVB) have a different provenance; shallow water fauna and tachylitic glass fragments indicate a source volcanic edifice that rose above the carbonate compensation depth and may have been emergent. Basaltic andesite intervals in upper subunit IVB have textures suggesting emplacement as intrusions into unconsolidated sediment on a volcanic center with geochemical and petrological characteristics of mafic, differentiated island arc magmatism. Distinctive Hf-Nd isotope characteristics similar to the least-radiogenic Izu-Bonin-Mariana boninites support a relatively old age for the basaltic andesites similar to detrital amphibole dated at 47 Ma. The absence of boninites at that time may have resulted from the position of Site U1438 at a greater distance from the plate edge. The upper interval of mudstone with tuffaceous beds (subunit IVA) progresses upsection into Unit III, part of a wedge of sediment fed by growing arc-axis volcanoes to the east. At Site U1438, in what was to become a reararc position, the succession of early extensional basaltic magmatism associated with spontaneous subduction initiation is followed by a rapid transition into potentially widespread subduction-related magmatism and sedimentation prior to the onset of focused magmatism and major arc building.
Transcirculation approach for stent-assisted coiling of intracranial aneurysms: a multicenter study
Authors: Mascitelli Justin R , Levitt Michael R , Griessenauer Christoph J , Kim Louis J , Gross Bradley , Abla Adib , Winkler Ethan , Jankowitz Brian , Grandhi Ramesh , Goren Oded , Schirmer Clemens M 
Published: November 2020

BackgroundThe transcirculation approach (TCA) for stent-assisted coiling (SAC) of intracranial aneurysms may be useful for certain wide-neck bifurcation aneurysms as well as those with acute-angle efferent branches.ObjectiveTo describe a multicenter experience using the TCA for SAC.MethodsA multicenter, retrospective study (2016–2020) of aneurysm treatment using SAC via the TCA. Angiographic outcome was scored using the Raymond Scale (adequate occlusion 1 and 2), and clinical outcome was scored using a modified Rankin Scale (good outcome 0–2)ResultsTwenty-nine patients with 29 aneurysms were included (62.1% female; average age 61; 89.7% unruptured; 13.8% previously treated; average dome size 6.4 mm; average neck 4.4 mm). Aneurysm locations included internal carotid artery–fetal posterior cerebral artery (n=4), internal carotid artery terminus (n=4), anterior communicating artery (n=8), vertebral artery–posterior inferior cerebellar artery (n=2), and basilar tip (n=11). The TCA used communicating arteries (93.1%; average 1.6 mm), intermediate catheters (51.7%), jailing technique (62.1%), and staged procedures (10.3%). The most common stent was the Neuroform Atlas (Stryker; 69%). Immediate adequate occlusion was obtained in 75.9%, and five patients with inadequate occlusion progressed to adequate occlusion at follow-up. One (3.4%) procedural complication occurred: a watershed stroke in the setting of baseline four-vessel extracranial disease. Two patients had a poor outcome unrelated to the TCA. The majority of patients (86.4%) had a good clinical outcome. One case of in-stent stenosis due to non-compliance with medication was seen, which resolved with medication resumption.ConclusionsThe TCA for SAC can be performed for a variety of aneurysms with a low complication rate and good clinical outcomes.
Changes in prolonged sedentary behaviour across the transition to retirement
Authors: Suorsa Kristin , Pulakka Anna , Leskinen Tuija , Pentti Jaana , Vahtera Jussi , Stenholm Sari 
Published: November 2020

BackgroundProlonged sedentary behaviour is associated with a higher risk of cardiometabolic diseases. This longitudinal study examined changes in daily total, prolonged (≥30 min) and highly prolonged (≥60 min) sedentary time across the transition to retirement by gender and occupational status.MethodsWe included 689 aging workers (mean (SD) age before retirement 63.2 (1.6) years, 85% women) from the Finnish Retirement and Aging Study (FIREA). Sedentary time was measured annually using a wrist-worn triaxial ActiGraph accelerometer before and after retirement with on average 3.4 (range 2–4) measurement points.ResultsWomen increased daily total sedentary time by 22 min (95% CI 13 to 31), prolonged sedentary time by 34 min (95% CI 27 to 42) and highly prolonged sedentary time by 15 min (95% CI 11 to 20) in the transition to retirement, and remained at the higher level of sedentary time years after retirement. The highest increase in total and prolonged sedentary time was observed among women retiring from manual occupations. Men had more total and prolonged sedentary time compared with women before and after retirement. Although no changes in men’s sedentary time were observed during the retirement transition, there was a gradual increase of 33 min (95% CI 6 to 60) in prolonged sedentary time from pre-retirement years to post-retirement years.ConclusionThe transition to retirement was accompanied by an abrupt increase in prolonged sedentary time in women but a more gradual increase in men. The retirement transition may be a suitable time period for interventions aiming to decrease sedentary behaviour.
Night shift work is associated with an increased risk of asthma
Authors: Maidstone Robert J , Turner James , Vetter Celine , Dashti Hassan S , Saxena Richa , Scheer Frank A J L , Shea Steven A , Kyle Simon D , Lawlor Deborah A , Loudon Andrew S I , Blaikley John F , Rutter Martin K , Ray David W , Durrington Hannah Jane 
Published: November 2020

IntroductionShift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large population to the risk of circadian misalignment-driven disease. Analysis of the impact of shift work on chronic inflammatory diseases is lacking. We investigated the association between shift work and asthma.MethodsWe describe the cross-sectional relationship between shift work and prevalent asthma in >280000 UK Biobank participants, making adjustments for major confounding factors (smoking history, ethnicity, socioeconomic status, physical activity, body mass index). We also investigated chronotype.ResultsCompared with day workers, ‘permanent’ night shift workers had a higher likelihood of moderate-severe asthma (OR 1.23 (95% CI 1.03 to 1.46)). Individuals doing any type of shift work had higher adjusted odds of wheeze/whistling in the chest. Shift workers who never or rarely worked on nights and people working permanent nights had a higher adjusted likelihood of having reduced lung function (FEV1<80% predicted). We found an increase in the risk of moderate-severe asthma in individuals with extreme chronotypes (morning, OR 1.55 (95% CI 1.06 to 2.27) or evening, OR 1.31 (95%CI 1.22 to 1.40)).ConclusionsThe public health implications of these findings are far-reaching due to the high prevalence and co-occurrence of both asthma and shift work. Future longitudinal follow-up studies are needed to determine if modifying shift work schedules to take into account chronotype might present a public health measure to reduce the risk of developing inflammatory diseases such as asthma.
Accuracy assessment of late winter snow depth mapping for tundra environments using Structure-from-Motion photogrammetry
Authors: Walker Branden , Wilcox Evan J. , Marsh Philip 
Published: November 2020

Arctic tundra environments are characterized by a spatially heterogeneous end-of-winter snow depth resulting from wind transport and deposition. Traditional methods for measuring snow depth do not accurately capture such heterogeneity at catchment scales. In this study we address the use of high-resolution, spatially distributed, snow depth data for Arctic environments through the application of unmanned aerial systems (UASs). We apply Structure-from-Motion photogrammetry to images collected using a fixed-wing UAS to produce a 1 m resolution snow depth product across seven areas of interest (AOIs) within the Trail Valley Creek Research Watershed, Northwest Territories, Canada. We evaluated these snow depth products with in situ measurements of both the snow surface elevation (n = 8434) and snow depth (n = 7191). When all AOIs were averaged, the RMSE of the snow surface elevation models was 0.16 m (<0.01 m bias), similar to the snow depth product (UASSD) RMSE of 0.15 m (+0.04 m bias). The distribution of snow depth between in situ measurements and UASSD was similar along the transects where in situ snow depth was collected, although similarity varies by AOI. Finally, we provide a discussion of factors that may influence the accuracy of the snow depth products including vegetation, environmental conditions, and study design.
Disnea en el servicio de urgencia
Authors: Sandoval Parra Maria Rosa , Lara Hernández Bárbara , Guzman Andres Ignacio 
Published: November 2020

La disnea es definida como la sensación subjetiva de ahogo o falta de aire y es un motivo muy frecuente de consulta. Su presentación clínica puede variar, desde manifestaciones leves hasta insuficiencia respiratoria catastrófica, con elevada mortalidad y requerir de terapias invasivas complejas.
En los servicios de urgencia se inicia el estudio etiológico del paciente agudo, al mismo tiempo que se realizan intervenciones terapéuticas destinadas a la estabilización y manejo tiempo-dependiente del paciente que consulta por disnea.
En vista de las múltiples causas de disnea, es necesario que el especialista en medicina de urgencia conozca los distintos diagnósticos diferenciales y sepa orientar su manejo y estudio.
Este manuscrito pretende dar un marco teórico acerca de la presentación del paciente con disnea en el servicio de urgencia, describir sus principales características y orientar el estudio y tratamientos tiempo-dependientes desde su primera evaluación por el equipo médico.
Se expone un caso clínico y revisan los componentes esenciales de la fisiopatología que explica la disnea, asi como la descripción de herramientas para su evaluación, tratamiento y disposición en el servicio de urgencia. Finalizaremos con la resolución del caso.
circIGHG-Induced Epithelial-to-Mesenchymal Transition Promotes Oral Squamous Cell Carcinoma Progression via miR-142-5p/IGF2BP3 Signaling
Authors: Liu Jingpeng , Jiang Xiao , Zou Ailing , Mai Zhaoyi , Huang Zhijie , Sun Liying , Zhao Jianjiang 
Published: November 2020

AbstractCircular RNAs (circRNA) are a new member of endogenously produced noncoding RNAs that have been characterized as key regulators of gene expression in a variety of malignances. However, the role of circRNA in oral squamous cell carcinoma (OSCC) remains largely unknown. In this study, we identified unique circRNA that regulate OSCC progression and metastasis and pave roads for future research in early diagnosis, prevention, and treatment of OSCC. Transcriptomic analyses identified a circRNA derived from IGHG locus (circIGHG) as significantly upregulated in OSCC and positively associated with poor prognosis of OSCC. circIGHG directly bound miR-142-5p and consequently elevated IGF2BP3 activity. Knockdown of circIGHG led to impaired expression of IGF2BP3 and attenuated aggressiveness of OSCC cells. Epithelial–mesenchymal transition was the main mechanism through which circIGHG/IGF2BP3 promotes metastasis of OSCC. Overall, these results demonstrate that circIGHG plays a pivotal role in OSCC development and metastasis and has potential to serve as a biomarker and therapeutic target for early-stage diagnosis and treatment of OSCC.Significance:These findings broaden our insights regarding regulation of OSCC progression by circular RNA and serve as a reference for future clinical research in OSCC diagnosis and treatment.
Activation of Receptor Tyrosine Kinases Mediates Acquired Resistance to MEK Inhibition in Malignant Peripheral Nerve Sheath Tumors
Authors: Wang Jiawan , Pollard Kai , Calizo Ana , Pratilas Christine A. 
Published: November 2020

Abstract

Malignant peripheral nerve sheath tumors often arise in patients with neurofibromatosis type 1 and are among the most treatment-refractory types of sarcoma. Overall survival in patients with relapsed disease remains poor, and thus novel therapeutic approaches are needed. NF1 is essential for negative regulation of RAS activity and is altered in about 90% of malignant peripheral nerve sheath tumors (MPNST). A complex interplay of upstream signaling and parallel RAS-driven pathways characterizes NF1-driven tumorigenesis, and inhibiting more than one RAS effector pathway is therefore necessary. To devise potential combination therapeutic strategies, we identified actionable alterations in signaling that underlie adaptive and acquired resistance to MEK inhibitor (MEKi). Using a series of proteomic, biochemical, and genetic approaches in an in vitro model of MEKi resistance provided a rationale for combination therapies. HGF/MET signaling was elevated in the MEKi-resistant model. HGF overexpression conferred resistance to MEKi in parental cells. Depletion of HGF or MET restored sensitivity of MEKi-resistant cells to MEKi. Finally, a combination of MEK and MET inhibition demonstrated activity in models of MPNST and may therefore be effective in patients with MPNST harboring genetic alterations in NF1.

Significance:
This study demonstrates that MEKi plus MET inhibitor may delay or prevent a novel mechanism of acquired MEKi resistance, with clinical implications for MPNST patients harboring NF1 alterations.
Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Authors: Geeraerts Shauni Lien , Kampen Kim Rosalie , Rinaldi Gianmarco , Gupta Purvi , Planque Mélanie , Louros Nikolaos , Heylen Elien , De Cremer Kaat , De Brucker Katrijn , Vereecke Stijn , Verbelen Benno , Vermeersch Pieter , Schymkowitz Joost , Rousseau Frederic , Cassiman David , Fendt Sarah-Maria , Voet Arnout , Cammue Bruno P.A. , Thevissen Karin , De Keersmaecker Kim 
Published: November 2020

Abstract
Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular serine and glycine supply, a significant subset of cancers becomes addicted to intracellular serine/glycine synthesis, offering an attractive drug target. Previously developed inhibitors of serine/glycine synthesis enzymes did not reach clinical trials due to unfavorable pharmacokinetic profiles, implying that further efforts to identify clinically applicable drugs targeting this pathway are required. In this study, we aimed to develop therapies that can rapidly enter the clinical practice by focusing on drug repurposing, as their safety and cost-effectiveness have been optimized before. Using a yeast model system, we repurposed two compounds, sertraline and thimerosal, for their selective toxicity against serine/glycine synthesis–addicted breast cancer and T-cell acute lymphoblastic leukemia cell lines. Isotope tracer metabolomics, computational docking, enzymatic assays, and drug–target interaction studies revealed that sertraline and thimerosal inhibit serine/glycine synthesis enzymes serine hydroxymethyltransferase and phosphoglycerate dehydrogenase, respectively. In addition, we demonstrated that sertraline's antiproliferative activity was further aggravated by mitochondrial inhibitors, such as the antimalarial artemether, by causing G1–S cell-cycle arrest. Most notably, this combination also resulted in serine-selective antitumor activity in breast cancer mouse xenografts. Collectively, this study provides molecular insights into the repurposed mode-of-action of the antidepressant sertraline and allows to delineate a hitherto unidentified group of cancers being particularly sensitive to treatment with sertraline. Furthermore, we highlight the simultaneous inhibition of serine/glycine synthesis and mitochondrial metabolism as a novel treatment strategy for serine/glycine synthesis–addicted cancers.
Abstract PO-037: The conversion of induced pluripotent stem cells into cancer stem cells under pancreatic cancer microenvironment is inhibiting by lapatinib
Authors: Hassan Ghmkin , Seno Masaharu 
Published: November 2020

Abstract
Cancer stem cells (CSCs) are suggested to be responsible for drug resistance and aggressive phenotypes of tumors. Mechanisms that regulating CSCs are still under investigation. Our lab has established a novel method to produce CSCs from induced pluripotent stem cells (iPSCs) under cancer microenvironment using conditioned medium (CM) from cancer cell lines. By treatment iPSCs with CM, cells gain CSC characteristics. Here, we analyzed transcriptome from CSCs, which converted from iPSCs using CM from pancreatic ductal adenocarcinoma cells, and differentially expressed genes were identified. Pathway enrichment was analyzed by the Kyoto Encyclopedia of Genes and Genomes (KEGG). Comparing iPSCs with CSCs converted from iPSCS showed elevated expression of genes related to ERBB2, ERBB3 and PI3K, while KEGG pathways revealed enrich of pathways known to be involved in cancer including ERBB2/ERBB3 signal pathway by conversion of iPSCs to CSCs. Inhibition of ERBB2 by lapatinib induced cell proliferation arrest and losing of tumorgenicity of converted cells. This study shows a potential involvement of ERBB2/ERBB3 pathway in CSCs generation and could lead to potentially new options for cancer treatment and prevention.
Citation Format: Ghmkin Hassan, Masaharu Seno. The conversion of induced pluripotent stem cells into cancer stem cells under pancreatic cancer microenvironment is inhibiting by lapatinib [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-037.
Prognostic Importance of Right Ventricular-Vascular Uncoupling in Acute Decompensated Heart Failure With Preserved Ejection Fraction
Authors: Nakagawa Akito , Yasumura Yoshio , Yoshida Chikako , Okumura Takahiro , Tateishi Jun , Yoshida Junichi , Abe Haruhiko , Tamaki Shunsuke , Yano Masamichi , Hayashi Takaharu , Nakagawa Yusuke , Yamada Takahisa , Nakatani Daisaku , Hikoso Shungo , Sakata Yasushi ,   on behalf of Osaka CardioVascular Conference (OCVC)-Heart Failure investigators
Published: November 2020

Background:
Recent accumulating evidence reveals that the right ventricular (RV)-pulmonary artery (PA) uncoupling is associated with poor outcome in patients with heart failure (HF), RV dysfunction, and pulmonary hypertension. However, the prognostic utility of RV-PA uncoupling in HF with preserved ejection fraction (HFpEF) remains elusive. In this study, we aim to investigate the associations of RV-PA uncoupling with outcomes of HFpEF inpatients.

Methods:
We prospectively studied 655 patients, registered in PURSUIT-HFpEF (The Prospective Multicenter Obervational Study of Patients with Heart Failure with Preserved Ejection Fraction), a multicenter observational study of Japanese HFpEF inpatients. We assigned registered patients based on the determined value of tricuspid annular plane systolic excursion/pulmonary artery systolic pressure ratio that can predict primary outcome as an indicator of RV-PA uncoupling.

Results:

Univariable Cox regression testing revealed that RV-PA uncoupling was associated with the primary endpoint of all-cause death, HF rehospitalization, and cerebrovascular events (hazard ratio [HR] 1.77 [95% CI, 1.34–2.32],
P
<0.0001) and the secondary endpoints of all-cause death and HF rehospitalization (HR 2.75 [95% CI, 1.77–4.33],
P
<0.0001, HR 1.63 [95% CI, 1.18–2.26],
P
=0.0036, respectively). Multivariable analysis also showed that RV-PA uncoupling was significantly associated with primary endpoint and all-cause death independent of age, sex, atrial fibrillation, renal dysfunction, elevated E/e’, and elevated NT-proBNP (N-terminal pro-B-type natriuretic peptide) (HR 1.38 [95% CI, 1.01–1.88],
P
=0.0413, HR 1.85 [95% CI, 1.14–3.01],
P
=0.0129, respectively).

Conclusions:
Prospective study of a hospitalized cohort revealed that RV-PA uncoupling was independently associated with adverse outcomes in acute decompensated patients with HFpEF.

Registration:

URL:
https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024414
. Unique identifier: UMIN000021831.