bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent Community-Acquired Bacterial Meningitis in Adults
Authors: ter Horst Liora , Brouwer Matthijs C , van der Ende Arie , van de Beek Diederik 
Published: October 2020

Abstract

Background
Recurrent bacterial meningitis has been found to occur in about 5% of meningitis cases.

Methods
We analyzed adults with recurrent episodes in a prospective nationwide cohort study of community-acquired bacterial meningitis.

Results
Of 2264 episodes of community-acquired bacterial meningitis between 2006 and 2018, 143 (6%) were identified as recurrent episodes in 123 patients. The median age was 57 years (interquartile range [IQR], 43–66), and 57 episodes (46%) occurred in men. The median duration between the first and the current episode was 5 years (IQR, 1–15). For 82 of 123 patients (67%), it was the first recurrent episode, 31 patients had 2–5 previous episodes (25%), 2 had 6–10 episodes (2%), and 2 had &gt;10 episodes (2%). Predisposing factors were identified in 87 of 118 patients (74%) and most commonly consisted of ear or sinus infections (43 of 120, 36%) and cerebrospinal fluid leakage (37 of 116, 32%). The most common pathogens were Streptococcus pneumoniae (93 of 143, 65%) and Haemophilus influenzae (19 of 143, 13%). The outcome was unfavorable (Glasgow outcome scale score, &lt;5) in 24 episodes with recurrent meningitis (17%) vs 810 for nonrecurrent meningitis patients (39%, P &lt; .001). Six of 143 died (4%) vs 362 of 2095 patients (17%, P &lt; .001).

Conclusions
Recurrent meningitis occurs mainly in patients with ear or sinus infections and cerebrospinal fluid leakage. Predominant causative pathogens are S. pneumoniae and H. influenzae. The disease course is less severe, resulting in lower case fatality compared with nonrecurrent meningitis patients.
Double trouble – thyro-pericarditis: rare presentation of Graves’ disease as pericarditis—a case report
Authors: Gondal Mohsin , Hussain Ali , Yousuf Hira , Haider Zahra 
Published: October 2020

Abstract

Background
Acute pericarditis is frequently encountered in clinical practice; however, pericarditis as the first presentation of Graves' disease is rare and mainly limited to case reports in the literature. We hereby report a case in which a young patient presented with pericarditis as the first manifestation of Graves’ disease.

Case summary
A 24-year-old male was admitted to hospital with presenting complaint of left-sided chest pain, gradual in onset, 6/10 in intensity, sharp in character, increased by deep breathing and improved by leaning forward. Patient also gave a history of insomnia, unintentional weight loss despite a good appetite, heat intolerance, and anxiety. On clinical examination, the patient had features of thyrotoxicosis, i.e., tachycardia, high volume pulse, and sweaty palms with fine tremors. There was no associated pericardial rub. Neck examination shows diffuse, non-tender goitre. Electrocardiogram findings were consistent with acute pericarditis. His thyroid function tests demonstrated hyperthyroidism and anti-thyroglobulin antibodies were also significantly elevated. Echocardiogram showed preserved left ventricular systolic function and a small global pericardial effusion without any signs of tamponade. He was diagnosed with Graves’ disease revealing itself as pericarditis and was started on ibuprofen, beta-blockers, and carbimazole. Patient had marked clinical and biochemical improvement on 3 monthly follow-ups.

Discussion
Thyro-pericarditis is a rare entity, and limited literature is available regarding this combination. The exact aetiology of Graves associated pericarditis is unknown. There is a possibility of interaction of autoantibodies with receptors on pericardium. Diagnosis is based on a detailed history, clinical examination, supplemented by relevant investigations (elevated free T4 and thyroid receptor antibodies, suppressed thyroid stimulating hormone (TSH) and Imaging via ultrasound). Mainstay of treatment includes non-steroidal anti-inflammatory drugs, beta-blockers, and anti-thyroidal medications.
Genetic association and characterization ofFSTL5in isolated clubfoot
Authors: Khanshour Anas M , Kidane Yared H , Kozlitina Julia , Cornelia Reuel , Rafipay Alexandra , De Mello Vanessa , Weston Mitchell , Paria Nandina , Khalid Aysha , Hecht Jacqueline T , Dobbs Matthew B , Richards B Stephens , Vargesson Neil , Hamra F Kent , Wilson Megan , Wise Carol , Gurnett Christina A , Rios Jonathan J 
Published: October 2020

AbstractTalipes equinovarus (clubfoot, TEV) is a congenital rotational foot deformity occurring in 1 per 1000 births with increased prevalence in males compared with females. The genetic etiology of isolated clubfoot (iTEV) remains unclear. Using a genome-wide association study, we identified a locus within FSTL5, encoding follistatin-like 5, significantly associated with iTEV. FSTL5 is an uncharacterized gene whose potential role in embryonic and postnatal development was previously unstudied. Utilizing multiple model systems, we found that Fstl5 was expressed during later stages of embryonic hindlimb development, and, in mice, expression was restricted to the condensing cartilage anlage destined to form the limb skeleton. In the postnatal growth plate, Fstl5 was specifically expressed in prehypertrophic chondrocytes. As Fstl5 knockout rats displayed no gross malformations, we engineered a conditional transgenic mouse line (Fstl5LSL) to overexpress Fstl5 in skeletal osteochondroprogenitors. We observed that hindlimbs were slightly shorter and that bone mineral density was reduced in adult male, but not female, Prrx1-cre;Fstl5LSL mice compared with control. No overt clubfoot-like deformity was observed in Prrx1-cre;Fstl5LSL mice, suggesting FSTL5 may function in other cell types to contribute to iTEV pathogenesis. Interrogating published mouse embryonic single-cell expression data showed that Fstl5 was expressed in cell lineage subclusters whose transcriptomes were associated with neural system development. Moreover, our results suggest that lineage-specific expression of the Fstl genes correlates with their divergent roles as modulators of transforming growth factor beta and bone morphogenetic protein signaling. Results from this study associate FSTL5 with iTEV and suggest a potential sexually dimorphic role for Fstl5 in vivo.
The Psychology of Poverty: Evidence from the Field
Authors: Molotsky Adria , Handa Sudhanshu 
Published: October 2020

Abstract
Individuals living in poverty are less likely to save and plan for the future, behaviour traditionally attributed to liquidity constraints and the associated need to address immediate consumption. Recent work on the behavioural consequences of poverty suggests that poverty induces stress and negative affect, which themselves directly influence economic decisions. We test this hypothesis using evaluation data from a national cash transfer program in Malawi in which some eligible households were randomly assigned to receive the transfer before others. We find that cash transfer reduces stress and improves positive affect, and positive affect has a direct effect on economic decisions.
The Vernacular Pulse of Sanskrit: Metre and More in Songs of theGītagovindaandBhāgavata Purāṇa
Authors: Pauwels Heidi 
Published: October 2020

AbstractThis article explores the metrical patterns of Gītagovinda’s songs, to investigate what they reveal about their origin and inspiration, building on previous scholarly research into the vernacular nature of the songs. Seemingly abstruse, metre lies at the heart of the performative nature of the text, but is often overlooked in a quest for meaning. The article starts with the approach of Sanskrit commentators, focusing on Mahārāṇā Kumbhakarṇa of Mewar’s fifteenth-century Rasikapriyā, interrelating with his theoretical work on music, the Saṃgītarāja. This reveals the problem of the discrepancy between metrical theory, or śāstra, and praxis, or prayoga, problematising the metrical pundits’ focus on classification and static definitions at the expense of rhythmical processes of actual performance. The article proposes an alternative by analysing Gītagovinda’s songs instead through the lens of New Indo-Aryan (NIA) poetry, which significantly enhances appreciation of the poetic craft of the author. Finally, comparison with selected Gopīgītas, or ‘Songs of the Gopīs’, from the ninth-century classic scripture of Krishna devotion, Bhāgavata Purāṇa, reveals parallels in both metre and oral formulae. Reading Gopīgītas in conjunction with Gītagovinda’s songs opens up a new perspective, revealing a vernacular pulse underlying some of the best-known and best-loved Sanskrit literature.
Quantification of the effect of site-specific histone acetylation on chromatin transcription rate
Authors: Wakamori Masatoshi , Okabe Kohki , Ura Kiyoe , Funatsu Takashi , Takinoue Masahiro , Umehara Takashi 
Published: October 2020

AbstractEukaryotic transcription is epigenetically regulated by chromatin structure and post-translational modifications (PTMs). For example, lysine acetylation in histone H4 is correlated with activation of RNA polymerase I-, II- and III-driven transcription from chromatin templates, which requires prior chromatin remodeling. However, quantitative understanding of the contribution of particular PTM states to the sequential steps of eukaryotic transcription has been hampered partially because reconstitution of a chromatin template with designed PTMs is difficult. In this study, we reconstituted a di-nucleosome with site-specifically acetylated or unmodified histone H4, which contained two copies of the Xenopus somatic 5S rRNA gene with addition of a unique sequence detectable by hybridization-assisted fluorescence correlation spectroscopy. Using a Xenopus oocyte nuclear extract, we analyzed the time course of accumulation of nascent 5S rRNA-derived transcripts generated on chromatin templates in vitro. Our mathematically described kinetic model and fitting analysis revealed that tetra-acetylation of histone H4 at K5/K8/K12/K16 increases the rate of transcriptionally competent chromatin formation ∼3-fold in comparison with the absence of acetylation. We provide a kinetic model for quantitative evaluation of the contribution of epigenetic modifications to chromatin transcription.
TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells
Authors: Xu Haiyue , Wang Junyan , Liang Ying , Fu Yujuan , Li Sihui , Huang Jinghan , Xu Heng , Zou Wei , Chen Baohui 
Published: October 2020

Abstract
A wealth of single-cell imaging studies have contributed novel insights into chromatin organization and gene regulation. However, a comprehensive understanding of spatiotemporal gene regulation requires developing tools to combine multiple monitoring systems in a single study. Here, we report a versatile tag, termed TriTag, which integrates the functional capabilities of CRISPR-Tag (DNA labeling), MS2 aptamer (RNA imaging) and fluorescent protein (protein tracking). Using this tag, we correlate changes in chromatin dynamics with the progression of endogenous gene expression, by recording both transcriptional bursting and protein production. This strategy allows precise measurements of gene expression at single-allele resolution across the cell cycle or in response to stress. TriTag enables capturing an integrated picture of gene expression, thus providing a powerful tool to study transcriptional heterogeneity and regulation.
Assisted peritoneal dialysis and transfer to haemodialysis: a cause-specific analysis with data from the RDPLF
Authors: Lanot Antoine , Bechade Clémence , Boyer Annabel , Ficheux Maxence , Lobbedez Thierry 
Published: October 2020

Abstract

Background
Technique failure, defined as death or transfer to haemodialysis (HD), is a major concern in peritoneal dialysis (PD). Nurse-assisted PD is globally associated with a lower risk of transfer to HD. We aimed to evaluate the association between assisted PD and the risk of the different causes of transfer to HD.

Methods
This was a retrospective study using data from the French Language PD Registry of patients on incident PD from 2006 to 2015. The association between the use of assisted PD and the causes of transfer to HD was evaluated using survival analysis with competing events in unmatched and propensity score-matched cohorts.

Results
The study included 11 093 incident PD patients treated in 123 French PD units. There were 4273 deaths, 3330 transfers to HD and 2210 renal transplantations. The causes of transfer to HD were inadequate dialysis (1283), infection (524), catheter-related problems (334), social issues (250), other causes linked to PD (422), other causes not linked to PD (481) and encapsulating peritoneal sclerosis (6). Nurse-assisted PD patients were older and more comorbid. Assistance by nurse was associated with a higher risk of death [cause-specific hazard ratio (cs-HR) 2.49, 95% confidence interval (CI) 2.26–2.74], but with a lower risk of transfer to HD [subdistributionHR (sd-HR) 0.68, 95% CI 0.62–0.76], especially due to inadequate dialysis (cs-HR 0.83, 95% CI 0.75–0).

Conclusions
The lower risk of transfer to HD associated with nurse assistance should encourage decision makers to launch reimbursement programmes in countries where it is not available.
Size reduction-induced properties modifications of antiferromagnetic dielectric nanocrystalline Ba2NiMO6 (M = W, Te) double perovskites
Authors: Bijelić Jelena , Tatar Dalibor , Sahu Manisha , Jagličić Zvonko , Djerdj Igor 
Published: October 2020

Abstract
The main objective of this work was to synthesize phase pure double perovskites Ba2NiTeO6 (BNTO) and Ba2NiWO6 (BNWO) in nanocrystalline form and to reveal the impact of nanocrystallinity on their magnetic and dielectric properties. The studied double perovskites were synthesized in nanocrystalline form by employing a citrate sol-gel route. A detailed investigation of their structure and properties using X-ray powder diffraction, scanning electron microscopy, Raman spectroscopy technique, energy-dispersive X-ray spectroscopy, SQUID magnetometry and electrical measurements is carefully described. Rietveld refinement of X-ray powder diffraction patterns revealed phase purity of both compounds: BNTO is trigonal (R-3m) while BNWO is cubic (Fm-3m). Raman spectroscopy studies reveal optical phonons that correspond to vibrations of Te6+/W6+O6 octahedra, while scanning electron microscopy images show irregular plate-like nanocrystals. Magnetic property measurements speak in favor of antiferromagnetic order but, in both compounds, size reduction affected their properties. BNTO has Néel temperature (TN) of 10.3 K which is higher than previously reported for its bulk form. Magnetic ground state of BNWO can be explained as canted antiferromagnetism with TN = 48.2 K. Room temperature measurements of dielectric constants at various frequencies suggest that these materials are high-κ dielectrics with low dielectric loss. The Nyquist plot reveals depressed a semicircle arc typical for non-Debye type of relaxation phenomena for BNWO ceramic, whereas for BNTO ceramic an almost straight line of Zʹʹ versus Z' has been observed, indicating its high insulating behavior. To conclude, size-dependent properties of studied double perovskites are discussed, introducing a possibility for implementation in electronic devices.
Frontostriatal Structural Connectivity and Striatal Glutamatergic Levels in Treatment-Resistant Schizophrenia: An Integrative Analysis of DTI and 1H-MRS
Authors: Ochi Ryo , Tarumi Ryosuke , Noda Yoshihiro , Tsugawa Sakiko , Plitman Eric , Wada Masataka , Honda Shiori , Matsushita Karin , Chakravarty M Mallar , Graff Guerrero Ariel , Fujii Shinya , Matsui Mie , Uchida Hiroyuki , Mimura Masaru , Nakajima Shinichiro 
Published: October 2020

Abstract
Given that approximately one-third of patients with schizophrenia do not respond to antipsychotics, different neurobiological bases may underlie treatment resistance in schizophrenia. Previous studies showed that treatment response is associated with both frontostriatal connectivity and glutamatergic neurometabolite levels in the caudate in patients with schizophrenia, which leads to the hypothesis that the relationship between them may be altered, specifically in patients with treatment-resistant schizophrenia (TRS). Employing analyses of covariance and subsequent partial correlation analyses, we compared the relationship between glutamate+glutamine (Glx) levels in the caudate and fractional anisotropy (FA) values in the tract between the dorsolateral prefrontal cortex and caudate in 19 patients with TRS, 20 patients responsive to first-line antipsychotics (FL-Resp), and 19 healthy controls (HCs). TRS was defined by severe positive symptomatology despite first-line antipsychotic treatment. Patients with TRS had lower FA values in the bilateral frontostriatal tracts than patients with FL-Resp and HCs (P &lt; .001), while no group differences were found in caudate Glx levels. There was a significant frontostriatal FA value-by-group interaction on caudate Glx levels (F = 7.37, P = .009). Frontostriatal FA values positively correlated with caudate Glx levels in HCs (r = −.55, P = .028), while they were negatively associated with caudate Glx levels in the TRS group (r = .53, P = .043). Furthermore, in the FL-Resp group, frontostriatal FA values did not significantly correlated with caudate Glx levels. The altered relationship between white matter integrity and the glutamate system in the frontostriatal circuit in the TRS group may reflect the pathophysiology underlying treatment response/resistance in schizophrenia.
Pain in Youth With Sickle Cell Disease
Authors: Alberts Nicole M. , Kang Guolian , Li Chen , Richardson Patricia A. , Hodges Jason , Hankins Jane S. , Klosky James L. 
Published: October 2020

Objectives:Pain is prevalent among youth with sickle cell disease (SCD). However, previous research has been limited by small sample sizes and lacked examinations of developmental differences in pain, which are critical to minimizing the development of chronic pain as youth transition into adulthood. The primary aim of the current study was to compare pain and pain interference across 4 developmental groups in a large sample of youth with SCD. The secondary aim was to identify risk factors for greater pain and pain interference.Materials and Methods:Utilizing a cross-sectional study design, the expression and predictors of pain and pain interference were compared across 4 developmental stages: toddlers/preschoolers (2 to 4 y), school-aged children (5 to 7 y), preadolescents (8 to 12 y), and adolescents (13 to 18 y). Participants included 386 youth with SCD and their caregivers.Results:Caregiver-reported pain and pain interference and youth-reported pain interference increased across developmental groups and plateaued approaching adolescence (multivariate analyses of varianceP=0.002 for pain andP<0.001 for pain interference). Elevated fatigue, anxiety, and perceived difficulties with pain management were the most robust predictors of higher youth- and caregiver-reported pain (βs ranging from 0.15 to 0.68;P<0.001) and pain interference (βs ranging from 0.18 to 0.64;P<0.001).Discussion:Disease and treatment-related variables were not associated with pain. Self-reported pain was elevated in older versus younger developmental groups and was largely linked to anxiety, fatigue, and perceptions of pain management, thus highlighting the modifiable nature of factors influencing pain among youth with SCD.
Investigating the Effects of Cuing Medication Availability on Patient-controlled Analgesia Pump Usage in Pediatric Patients
Authors: Hainsworth Keri R. , Czarnecki Michelle L. , Simpson Pippa M. , Zhang Liyun , Davies William H. , Mueller Devin , Weisman Steven J. 
Published: October 2020

Objectives:
The study of patient-controlled analgesia (PCA) behaviors has led to a greater understanding of factors that affect the pain experience. Although PCA behaviors can be influenced by cues to medication availability, no studies have examined the effects of such cues in pediatric populations.

Materials and Methods:
This randomized controlled trial examined patient satisfaction with pain management, PCA behaviors, opioid consumption, and state anxiety in a sample of 125 postsurgical children and adolescents (7 to 17 y). Patients were randomized to a “light” group (lockout period status cued by light on the PCA button) or control group (no cues to medication availability).

Results:
Although cuing did not affect patient satisfaction with pain management (P=0.11), patients in the light group consumed significantly more opioid than those in the control group (adj. P=0.016). This effect was primarily because of children in the light group (median, 0.019; interquartile range, 0.012 to 0.036 mg/kg/h) consuming more opioid than children (12 y or younger) in control group (median, 0.015; interquartile range, 0.006 to 0.025 mg/kg/h) (P=0.007). In contrast to the control group, for patients in the light group, opioid consumption was unrelated to pain and the proportion of patients with a 1:1 injections:attempts ratio was higher (P<0.001) across the study period.

Discussion:
The overall pattern of results suggests that patients in the light group used their PCA in response to the light more than in response to their pain, which likely reflects operant influences on PCA behavior by pediatric patients.
Physical Therapy Interventions for a Patient Requiring Prolonged Intubation Due to Severe COVID-19: A Case Study
Authors: Black Katelyn , Walters Carly 
Published: October 2020

Abstract
There is little published information available to guide the acute care physical therapist in caring for acutely ill patients with COVID-19. Significant debility after prolonged stays in the intensive care unit can make rehabilitation more difficult. In this case, a 54-year-old man spent 1 month on mechanical ventilation before initiating therapies. Despite his poor medical prognosis, intensive therapies were initiated—including cardiopulmonary interventions, therapeutic exercise, and neuromuscular re-education. The patient displayed profound improvement and was able to discharge to an inpatient rehabilitation facility.