bluuebunny/crossref_metadata_2025_split huggingface dataset:
A protocol for the development of a Core Outcome Set for PREgnancy Nutrition (PRENCOS)
Authors: Killeen Sarah Louise , O'Brien Eilleen C. , Geraghty Aisling A. , McAuliffe Fionnuala M. 
Published: June 2020

AbstractIntroduction:Maternal nutrition during pregnancy is a modifiable risk factor for health. Heterogeneity in outcome reporting in studies evaluating nutrition in pregnancy limits their comparability and is a barrier for high quality evidence synthesis. A core outcome set (COS) is set of outcomes, which are agreed by consensus, to be a minimum standard to report within an area of research. The CoRe Outcomes in Women's and Newborn health (CROWN) initiative is an international initiative which supports the development of COSs for Women and Newborn health research. To date, there is no COS which specifically addresses the issues with outcome reporting in research on nutrition in pregnancy. Therefore, we present a study protocol for the development of a COS for maternal nutrition research in pregnancy.Methods:The COS is registered with the Core Outcomes for Measurement of Effectiveness Trials (COMET) registry. A systematic review will be conducted following PRISMA guidelines to identify studies evaluating maternal nutrition during pregnancy. Outcomes will be extracted from eligible studies and cataloged using the taxonomy of the COMET initiative. We will make efforts to supplement our findings with outcomes from other sources, including qualitative interviews with mothers. Secondly, a modified Delphi survey will be conducted with international stakeholders including healthcare professionals, researchers and mothers. Participants will be presented with the list of outcomes from step one and invited to rank the importance of including each outcome in the final COS using a 9-point Likert scale. We will complete descriptive statistics and in a second round of the survey, participants will receive feedback on their individual scores from round one, along with the average score each stakeholder group provided for each outcome. Based on this, participants will have the opportunity to change their scoring and will be encouraged to give a rationale for their final choice. Lastly, a face-face consensus meeting will be held with representatives from all stakeholder groups to finalise the COS.Results:We will identify the outcomes reported in maternal nutrition research. We will also determine the outcomes which are important to pregnant women and if these are missing from the literature. A final COS for nutrition research in pregnancy will be developed.Discussion:This COS will support the harmonisation of outcome selection and reporting in maternal nutrition research which is necessary for high quality evidence synthesis to support clinical practice and the nutritional care of pregnant women.
What can researchers learn from participant involvement? Insights from the ROLO Family Advisory Committee
Authors: Brien Eileen O. , Walsh Niamh , Geraghty Aisling , Byrne David , McAuliffe Fionnuala 
Published: June 2020

AbstractIntroduction:Public and patient involvement (PPI) describes how researchers collaborate and engage with the public in order to make research more relevant to them. The ROLO Family Advisory Committee is a self-selected group of parents who are involved in the longitudinal follow-up of the ROLO Study. It was established in 2017 and the goal is to achieve a partnership between ROLO families and researchers, leading to improved research quality, relevance and outcomes. The aim of engaging with parents from the ROLO study is to understand key outcomes of importance for parents relating to their own health and their children's health and to gain insights into how the research agenda can be more relevant to parent and child needs.Materials and Methods:All parents involved with ROLO study were invited to join the ROLO Family Advisory Committee in 2017. Parents who had expressed interest in joining the committee were invited to attend annual ROLO Families Advisory Committee Meetings in 2018 and 2019. Parents were asked to discuss their opinions about current research projects and potential future projects. This was followed by an open discussion about relevant health questions. These meetings were either transcribed on the day or recorded with audio recordings transcribed verbatim and broad themes identified.Results:Mothers had greater concern for outcomes relating to their children than themselves. Parents were very interested in understanding the relationship between diet in pregnancy and child health and welcomed research regarding blood tests that could be predictors of future health. Parents had great concern for the effect social media has on child mental health and also wanted more studies conducted in the areas of fussy eating and how to ensure children consume a wide range of healthy foods. It was consistently highlighted that children and teenagers should understand healthy eating principles and ways to promote their physical and mental health.Discussion:Through the two focus groups, valuable insights were gained regarding what research parents consider relevant and future research questions. The ROLO agenda has certainly been enriched by PPI. We are seeking opportunities to enable research to be carried out in the areas discussed at the meetings.
The Role of Zinc in Depressed Pregnant and Non-Pregnant Women: A Systematic Review and Meta-Analysis
Authors: Page Nadine B. , Brown Anna M. , Pascoe Erin , Braithwaite Sally , Townsend Michelle L. , Herbert Jane S. , Davies Hilary , Hart Kathryn H. , Moore J. Bernadette 
Published: June 2020

AbstractPerinatal depression is a depressive illness that affects 10–15% of women in the UK with an estimated cost of £1.8 billion/year. Zinc deficiency is associated with the development of mood disorders and zinc supplementation has been shown to help reduce the symptoms of depression. Women who are pregnant and breastfeeding are at risk of lower levels of zinc because of the high demand from the developing and feeding baby. However, studies in the perinatal period are limited. With a long-term aim of designing a randomised controlled trial (RCT) to examine if zinc supplementation reduces depressive symptoms in pregnant and lactating women;the objective of this review was to systematically evaluate previous RCTs assessing zinc supplementation and depressive symptoms, in order to establish a zinc dosing regimen with regards to Galenic formulation, unit dose and frequency. The review was conducted by independent reviewers in accordance with PRISMA guidelines and is registered at Prospero (CRD42017059205). The Allied and Complimentary Medicine, CINAHL, Embase, MEDLINE, PsycINFO, PubMed, and Cochrane databases were searched since records began, with no restrictions, for intervention trials assessing Galenic formulation, unit dose and frequency of zinc supplementation to reduce the symptoms of depression. From a total of 66 identified records, 7 articles met the inclusion and exclusion criteria; all assessed the effect of zinc supplementation on mood. Risk of bias was independently assessed using the standard ‘Cochrane risk of bias tool’. Overall, 5 of the 7 papers were rated as high-quality trials; of the other two, one was rated poor and the other fair but both had a number of learning points. Preliminary findings indicate at the end of supplementing zinc, depression scores were reduced significantly. In one study, the Beck score decreased in the placebo group, but this reduction was not significant compared to the baseline. In two of the studies there was a significant correlation between serum zinc and self-reported mood questionnaires. Results also suggest that 25 mg zinc supplementation combined with antidepressant drugs can be effective in the treatment of major depression in women. This supports other work where researchers supplemented 25 mg of elemental zinc for 12 weeks or longer and found a reduction of symptoms in both pregnant and non-pregnant women. Thus, an early conclusion is that 25 mg of elemental zinc is an effective dose for improving low mood and is achievable in a trial setting.
Bioactive compounds and antioxidant capacity in fennel seeds influenced by pressurized liquid extraction
Authors: Repajić Maja , Tonković Petra , Kruk Valentina , Zorić Zoran , Elez Garofulić Ivona , Palčić Igor , Dragović-Uzelac Verica 
Published: June 2020

AbstractFennel (Foeniculum vulgare Mill.) is a well-known aromatic plant, widely used as spice and remedy herb. It provides many beneficial effects and is used as diuretic and expectorant, as well as for various dyspeptic disorders. Beside essential oils, fennel seeds are abundant with various phenols, which are known as strong antioxidants and thereby contribute to human health. Among different extraction methods for phenols isolation, pressurized liquid extraction (PLE) represents a novel technique with numerous advantages over conventional extraction approaches. Its efficiency manifests through combination of high temperature and pressure, enabling extraction time shortening, as well as decreased solvent consumption, thus being environment-friendly technique. In order to achieve maximum extraction yield, it is of great importance to select optimal PLE conditions, e.g., extraction temperature and time. Additionally, solvent selection also affects on content of targeted compounds, where phenols amount depends on polarity of solvent. Hence, the aim of this study was to examine the effect of temperature (75 and 100 °C), static time (5 and 10 min) and cycle number (1, 2 and 3) on total phenols (TP) and total flavonoids (TF) content, as well as the antioxidant capacity (AC) in fennel seeds using three-step exhaustive PLE. Firstly, grinded dry fennel seeds were subjected to PLE using non-polar solvent (hexane) under the mentioned conditions in order to remove seeds' lipid fraction. Afterwards, defatted samples were extracted with polar solvents by the increasing polarity: aqueous acetone solution (30 %, v/v) followed by aqueous methanol solution (30 %, v/v). Obtained acetone (AE) and methanol (ME) extracts (n = 24) were analyzed for TP (Folin-Ciocalteu method), TF (aluminium chloride colorimetric assay) and AC [ferric reducing antioxidant power (FRAP) method]. Multivariate analysis of variance (MANOVA) and Tukey's HSD test (p ≤ 0.05) were applied for statistical analysis of collected data. Expectedly, AE were described with higher values of analyzed parameters (grand means: TP = 416.18 mg/100 g, TF = 41.87 mg/100 g, AC = 359.57 mg AAE/100 g) in comparison with ME (grand means: TP = 80.25 mg/100 g, TF = 16.41 mg/100 g, AC = 96.13 mg AAE/100 g. Furthermore, all examined influences significantly affected TP, TF and AC in all samples, except temperature on TP in ME. Thus, conditions of 100 °C/10 min/3 cycles showed the greatest yield of tested parameters in AE, while 100 °C/5 min/1 cycle were sufficient for maximum TP and AC levels in ME. Regarding TF in ME, slightly longer extraction time was required to achieve the highest efficiency (100 °C/10 min/1 cycle).
Microbial production of essential and toxic compounds among oat-using CeD and NCGS patients
Authors: Hakkola Salla , Nylund Lotta , Yang Baoru , Kalliomäki Marko , Linderborg Kaisa 
Published: June 2020

AbstractThe recent development of diagnostic methods and current well-being trend have increased the awareness of gluten-related diseases, such as celiac disease (CeD) and non-celiac gluten sensitivity (NCGS), 1% and 6 % of general population, respectively. Currently for both CeD and NCGS, the only effective treatment is a life-long gluten-free diet, which makes adequate intake of fiber challenging. Despite of improving gut function, dietary fibers promote the growth of gut beneficial microbes. They are in charge of production of numerous compounds, which are essential for human health, such as enzymes and short chain fatty acids (SCFA). Moreover, dietary fiber has an effect on ammoniacal nitrogen levels and beta-glucuronidase activity, which are harmful for human in high concentrations. Gluten-free oats are an excellent source of dietary fiber and they have exceptionally good nutritional properties.In this observational study, SCFA production, ammoniacal nitrogen levels and beta-glucuronidase activity of oat-using CeD patients, NCGS patients and healthy controls were compared. SPME-GC-MS method was developed for SCFA analysis and the other biomarkers were analyzed by spectrophotometer.There were no significant differences between groups on propionic acid and butyric acid production, only the percentage of acetic acid of total SCFAs was higher in control group compared to NCGS group, (p = 0,03). Neither was there significant differences between groups in ammonia production or beta-glucuronidase activity.It has been scientifically proven that pure oats are suitable for celiac disease and gluten-sensitive patients, but they are not commonly used outside of Scandinavia. Our results stated that oat-using CeD and NCGS patients, whose disease is in balance, have gut microbiota capable of healthy production of essential SCFAs and normal levels of harmful compounds.
Characterising the plant based component of the Irish diet in terms of its nutritional quality
Authors: Kent Gráinne , Kehoe Laura , McCarthy Róisín , McNulty Breige A. , Nugent Anne P. , Flynn Albert , Walton Janette 
Published: June 2020

AbstractA diet rich in plant-based foods with fewer animal products may offer improved health and environmental benefits. There is little consensus on the definition for a plant-based diet in the literature with some defining it as one rich in vegetables, legumes, fruits, wholegrains, nuts and seeds, excluding animal foods and with heavy restrictions on processed foods. Other definitions make no reference to the inclusion/exclusion of processed foods and refer only to the exclusion of all animal foods from the total diet. This study aimed to examine the nutritional quality of the Irish diet using each of these plant-based diet definitions.A 4-day semi-weighed food record collected food intake data from 1500 Irish adults (18–90y) in the National Adult Nutrition Survey (NANS). Nutrient intake was analysed using WISP© based on UK and Irish food composition databases. All foods and beverages consumed in the NANS were categorised (included/excluded) into the two definitions; 1.plant-based component of the diet and 2.total diet excluding all animal components. The plant-based component included vegetables, legumes, fruits, wholegrains, nuts and seeds and excluded all animal foods and processed foods. The second categorisation included all non-animal foods regardless of processing. Nutritional quality was assessed by estimating energy-adjusted intakes of macronutrients, saturated fat, free sugars, dietary fibre and sodium. Stastical analysis was conducted using SPSS© v24.The plant-based component of the diet provided 309 ± 214kcal/d (1.3 ± 0.9MJ/d) comprising of 68% carbohydrate, 20% fat and 12% protein. Mean intakes of saturated fat and free sugars from the plant-based component of the diet were 5% of energy (%E) and 1%E, respectively. Mean intakes of dietary fibre and sodium were 70g/10MJ and 1855mg/10MJ, respectively.Allowing for inclusion of processed foods, mean energy intake from the total diet excluding all animal foods was 1051 ± 411kcal/d (4.4 ± 1.7MJ/d) comprising of 66% carbohydrate, 23% fat and 10% protein. Mean intakes of saturated fat and free sugars were 7%E and 14%E, respectively. Mean intakes of dietary fibre and sodium were 40g/10MJ and 2642mg/10MJ, respectively.Overall, the macronutrient profile of the plant-based component of the diet and the total diet excluding animal foods were similar. However, the plant-based component of the diet was of higher nutritional quality; providing lower intakes of saturated fat, free sugar and sodium and higher intakes of dietary fibre compared to the total diet excluding animal foods. This study highlights the variability in nutritional quality between different definitions of plant based-diets.
Application of the WHO nutrient profile model on food product data recorded for the Austrian project “Food in the Spotlight”
Authors: Meidlinger Bettina , Luipersbeck Christian , Bruckmüller Melanie U. , Dieminger-Schnürch Birgit , Bürger-Schwaninger Bernadette , Spitzbart Stefan , Schindler Karin , Fuchs Klemens , Wolf-Spitzer Alexandra 
Published: June 2020

AbstractIntroduction:Children are exposed to marketing of foods with a high content of energy, fat, sugar and salt on a daily basis, which can have negative consequences via increasing children's preferences for those foods. An unhealthy diet can promote obesity and other noncommunicable diseases. The objective of this scientific work was to assess the applicability of the nutrient profile model (NPM) for food products available in the Austrian market. The model was developed by the WHO Regional Office for Europe to reduce the impact of marketing to children.Material and Methods:The NPM was applied to food product information, which was recorded for the project “Food in the Spotlight” (www.lebensmittellupe.at). Food products were assigned to food categories made by the WHO and the NPM was applied to identify products, which should not be allowed to be marketed to children. As the WHO NPM is flexible and can be adapted to the national context possible adaptations of the model to the Austrian market were developed.Results:Among those product groups which were included in Food in the Spotlight 0% of cocoa (n = 89), milk drinks with additional ingredients (e.g. strawberry milk, n = 111), soup pearl croutons (n = 13), ketchups (n = 79) and pestos (n = 119), 0.4% of soft drinks (Cola, lemonade etc., n = 454), 8% of pizza and pizza-like products (n = 274), 13% of yoghurt products with additional ingredients (n = 611), 18% of sugos (n = 193), 28% of fruit and vegetable purees (n = 36) and 33% of breakfast cereals (n = 678) were found to be eligible for marketing to children. Those 0.4% of soft drinks which would be allowed are two waters flavoured with aroma. Pure products such as whole milk and yoghurts with 3.5% fat would not be allowed because they exceed the thresholds for total fat. For those products with a packaging appealing to children and adolescents almost none passed the NPM.Conclusion:Our results showed, that before the NPM can be implemented in Austria, it is important to adapt the model to national dietary guidelines. Additionally, food categories could be modified to be more suitable for the Austrian market, as some products which are common in Austria could not be easily assigned to the WHO food categories. To adapt the WHO NPM to the national context cooperation between health experts and food manufacturers is necessary.
Analysis of implementation of global nutrition policies to tackle the double burden of malnutrition in Nigeria, Zambia and Indonesia
Authors: van den Assum Sylvie J. P. , Lambert Semnen R. , de Bresser Inge , Schilpzand Rutger A. 
Published: June 2020

AbstractThe double burden of malnutrition (DBM) is described as the co-existence of undernutrition and overweight or diet-related non-communicable diseases within a country, community or an individual (WHO). It is a major global issue, affecting approximately half of the worlds’ population. International organizations have published policy reports to function as guidelines for national implementation to tackle the double burden of malnutrition. The goal of this study is to analyze the advancement of the implementation of these recommendations in a number of middle-income countries.Reports and recommendations on policies against DBM from 10 leading international organizations are analyzed and compared on several aspects, such as proposed measures, stakeholder involvement and target population. These organizations are UN, FAO, WHO, EAT forum, GAIN, World Food Program, World Bank, UNICEF, IFPRI and Global Panel on Agriculture and food systems for Nutrition. The level of implementation of the described policies is studied for Nigeria, Zambia and Indonesia by means of desk research and stakeholder interviews. These (semi-structured) interviews are based on the encountered information gaps within the desk research. Stakeholders were selected from a variety of organizations, such as government, NGO's, consumer organizations, science and industry in order to be able to examine the subject from different angles.The study is still ongoing at the time of abstract submission. The (preliminary) results and conclusions will be presented and they are expected to describe per country which nutrition policies against DBM are initiated or implemented. Major learnings and best practices of these implementations will be reported and major differences and similarities between implementations in Nigeria, Zambia and Indonesia will be described and compared with the policy guidelines from the leading health organizations. These results may be used as learning when policies against DBM are newly implemented in other middle-income countries or to improve existing policies.
Sugar content of yogurt products in the UK: A comparison between 2016 and 2019
Authors: Sutton Eimear , Hancock Neil , Moore J. Bernadette 
Published: June 2020

AbstractYogurt is a staple part of children's diets and is perceived as a nutrient dense food for adults and children. However, yogurts are also a significant source of free sugars for children and are a target of the UK government's sugar reduction programme, which has recommended a 20% reduction in the sugar content of yogurt and fromage frais products by 2020. With this in mind, in November 2016, we undertook a comprehensive survey of the nutrient contents of yogurt products in UK supermarkets (Moore et al. 2018). The aim of this work was to reassess the UK supermarkets yogurt products in 2019 and determine whether the sugar contents of yogurt products have been reduced. Product data was collected from the UK's top five online supermarkets in January 2019 using the search terms ‘yogurt’ and ‘yoghurt’. Products were placed systematically into the same 8 categories used in 2016: children's, drinks, dairy alternatives, organic, natural/Greek, fruit, flavoured, desserts. Products lists were collected, refined and compared to the 2016 database. All data was double-checked independently and 5% of all entries were randomly selected and verified. GraphPad Prism V/7.0c was used for statistical analysis. After de-duplication of products found in multiple supermarkets, the 2019 database contained 893 unique products in line with the 898 surveyed in 2016. Of these, 539 (60.4%) yogurts were in common (same brand and name) with the 2016 products and 354 were new, demonstrating dynamic turnover in available yogurt products during the 26 months between surveys. In comparing the total sugar contents of the 539 paired products, notably the median [range] of total sugar contents in 2019 was significantly lower than in 2016 (10.8g/100 g [0.4, 29.5] versus 11.8g/100 g [0.1, 31.8]; P < 0.0001, Wilcoxon matched-pairs signed rank test). Indeed, when all products were compared there was a significant reduction in the median total sugar in 2019 compared to 2016 (10.4g/100 g [0–32.9] versus 11.9g/100 g [0.1–32.6]; P < 0.0001, Mann-Whitney test). Categories showing the most improvements were children's, drinks and fruit yogurts. Fifteen percent of the 2019 products contained less than or equal to 5g/100 g sugars, considered a ‘low sugar’ product, an improvement over the 9% identified in 2016. We conclude the sugar content of UK yogurt products has reduced since the sugar reduction program was put into place in 2016. However, a larger reduction in most categories is needed in order to reach the required 20% reduction by 2020.