bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBUATAN APLIKASI DALAM MENGINTEGRASIKAN DATA KEUANGAN, DATA ORDER, DAN DATA STOK PADA UKM MOST BROTHERS DI DEPOK JAWA BARAT
Authors: Lasminiasih Lasminiasih , Sartika Sartika , Putri Pratiwi Ranti 
Published: February 2020

Abstract
Most Brothers are Small Medium Enterprise (SME) in the printing or canvass clothes, shirts, hat, bags and others in the city of Depok. Currently, Most Brothers is still using the system of recording financial data, order data, and stock data manually or not computerized. This research aims to propose the use of a system information such as application in integrating financial data, order data, and stock data. The method used in this research is descriptive qualitative by conducting observations and interviews directly. In making application, used design database desktop based MYSQL application. The output produced by this application is a simple financial report consisting of income statement and cash flow. There is also a order data report to complete consumer orders in structured and timely. As well as, report of stock data to find out the number of raw materials available.

Keywords: Information System, Application, Financial Report, Order Data, Stock Data, Small Medium Enterprises (SME)

Abstrak
Most Brothers adalah Usaha Kecil Makro (UKM) dalam bidang percetakan atau sablon baju, kaos, topi, tas dan lain-lain di kota Depok. Saat ini, Most Brothers masih menggunakan sistem pencatatan data keuangan, data order, dan data stok secara manual atau belum terkomputerisasi. Penelitian ini bertujuan untuk mengusulkan pembuatan sistem informasi berupa aplikasi untuk mengintegrasikan data keuangan, data order, dan data stok. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan malakukan observasi dan wawancara secara langsung. Dalam pembuatan aplikasi, digunakan perancangan database berbasis desktop dengan aplikasi MySQL. Output yang dihasilkan aplikasi ini yaitu laporan keuangan sederhana yang terdiri dari laba rugi dan arus kas. Terdapat pula Laporan data order untuk menyelesaikan pesanan konsumen secara terstruktur dan tepat waktu. Serta, laporan data stok barang untuk mengetahui jumlah bahan baku produksi yang tersedia.
PENGABDIAN MASYARAKAT MELALUI PEMANFAATAN JALAN TERAPI PADA LANSIA DI DESA SUMBER SARI, KUTAI KARTANEGARA
Authors: Febriyanto Kresna , Sunarti Sri , Suprayitno  , Rachman Ainur 
Published: February 2020

Abstract
The disease that most attacks the elderly one of which is hypertension. The hypertension is one of the main public health problems today. The prevalence of hypertension is 25.8% of Indonesia's population. If not handled properly as early as possible can be the number 1 killer of humanity. Community service activities carried out with the aim of improving the health status of the elderly by using therapeutic roads as an alternative in overcoming hypertension in Sumber Sari Village, Kec. Loa Kulu Kab. Kutai Kartanegara. The method of community service is training, and health education in the use of therapeutic roads in the Posyandu Elderly Anggrek Ungu Sumber Sumber village followed by 29 elderly people. The introduction of therapy is carried out in January 2018 and is then applied by the elderly every day. Posyandu cadres that have been formed to monitor the elderly in the utilization of therapeutic roads that have been made. In addition, by doing health education, the elderly can realize about maintaining daily health and not consuming foods that cause excessive hypertension.

Abstrak
Penyakit yang paling banyak menyerang lansia salah satunya adalah penyakit hipertensi. Hipertensi merupakan salah satu masalah utama kesehatan masyarakat saat ini. Prevalensi hipertensi sebesar 25,8% penduduk Indonesia. Bila tidak ditangani dengan baik sedini mungkin bisa menjadi pembunuh nomor 1 umat manusia. Kegiatan pengabdian masyarakat dilaksanakan dengan tujuan meningkatkan derajat kesehatan lansia dengan pemanfaatan jalan terapi sebagai salah satu alternatif dalam mengatasi penyakit hipertensi di Desa Sumber Sari Kec. Loa Kulu Kab. Kutai Kartanegara. Metode pengabdian masyarakat ini yaitu pelatihan, dan pendidikan kesehatan dalam pemanfaatan jalan terapi di Posyandu Lansia Anggrek Ungu Desa Sumber Sari diikuti oleh 29 orang Lansia. Pengenalan jalan terapi dilaksanakan pada Januari 2018 dan selanjutnya diaplikasikan oleh lansia setiap harinya. Kader posyandu yang telah terbentuk melakukan pemantauan lansia dalam pemanfaatan jalan terapi yang telah dibuat. Selain itu, dengan dilakukannya pendidikan kesehatan, lansia dapat menyadari tentang menjaga kesehatan sehari-hari dan tidak mengkonsumsi makanan yang memicu hipertensi secara berlebihan.
Tuberculosis of the Spine
Authors: Jain Anil Kumar , Rajasekaran S. , Jaggi Karan Raj , Myneedu Vithal Prasad 
Published: February 2020

➢ Diagnosis of spinal tuberculosis (TB) in the early (inflammatory) stage is essential to prevent the development of spinal deformity and neurological deficit.➢ As spinal TB is a paucibacillary disease, diagnosis is established through a combination of clinical evaluation, imaging features, acid-fast bacilli smear, mycobacterial culture, histologic and/or cytologic evaluation, and molecular methods of diagnosis. No single modality can ascertain a diagnosis in all cases.➢ Spinal TB is a medical disease to be treated by antitubercular therapy (ATT) until healing is attained. The consensus for the definition of a healed status in bone and joint TB, and consequent length of ATT intake, remains unresolved. Children with spinal TB need to be followed until skeletal maturity as kyphotic deformity may increase with growth.➢ The indications for surgery and type of surgery performed (decompression, instrumented stabilization, or deformity correction) are case-specific decisions. Surgical correction of spinal deformity is easier to perform in active disease than in healed disease.➢ Drug-resistant strains present an emerging challenge. Demonstration of drug resistance is often difficult in patients with spinal TB because of the lack of bacterial growth on culture. Molecular methods of diagnosis are often useful in such patients. Establishment of treatment protocols requires further long-term and large-scale clinical trials.
Intramedullary Nailing Versus External Fixation in the Treatment of Open Tibial Fractures in Tanzania
Authors: Haonga Billy T. , Liu Max , Albright Patrick , Challa Sravya T. , Ali Syed H. , Lazar Ann A. , Eliezer Edmund N. , Shearer David W. , Morshed Saam 
Published: February 2020

Background:
Open tibial fractures are common injuries in low and middle-income countries, but there is no consensus regarding treatment with intramedullary nailing versus external fixation. The purpose of the present study was to compare the outcomes of initial treatment with intramedullary nailing or external fixation in adults with open tibial fractures.

Methods:
We conducted a randomized clinical trial (RCT) at a tertiary orthopaedic center in Tanzania. Adults with acute diaphyseal open tibial fractures were randomly assigned to statically locked, hand-reamed intramedullary nailing or uniplanar external fixation. The primary outcome was death or reoperation for the treatment of deep infection, nonunion, or malalignment. Secondary outcomes included quality of life as measured with the EuroQol-5 Dimensions (EQ-5D) questionnaire, radiographic alignment, and healing as measured with the modified Radiographic Union Scale for Tibial fractures (mRUST).

Results:
Of the 240 patients who were enrolled, 221 (92.1%) (including 111 managed with intramedullary nailing and 110 managed with external fixation) completed 1-year follow-up. There were 44 primary outcome events (with rates of 18.0% and 21.9% in the intramedullary nailing and external fixation groups, respectively) (relative risk [RR] = 0.83 [95% confidence interval (CI), 0.49 to 1.41]; p = 0.505). There was no significant difference between the groups in terms of the rate of deep infection. Intramedullary nailing was associated with a lower risk of coronal malalignment (RR = 0.11 [95% CI, 0.01 to 0.85]; p = 0.01) and sagittal malalignment (RR = 0.17 [95% CI, 0.02 to 1.35]; p = 0.065) at 1 year. The EQ-5D index favored intramedullary nailing at 6 weeks (mean difference [MD] = 0.07 [95% CI = 0.03 to 0.11]; p < 0.001), but this difference dissipated by 1 year. Radiographic healing (mRUST) favored intramedullary nailing at 6 weeks (MD = 1.2 [95% CI = 0.4 to 2.0]; p = 0.005), 12 weeks (MD = 1.0 [95% CI = 0.3 to 1.7]; p = 0.005), and 1 year (MD = 0.8 [95% CI = 0.2 to 1.5]; p = 0.013).

Conclusions:
To our knowledge, the present study is the first RCT assessing intramedullary nailing versus external fixation for the treatment of open tibial fractures in sub-Saharan Africa. Differences in primary events were not detected, and only coronal alignment significantly favored the use of intramedullary nailing.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Pengaruh Etika Bisnis Terhadap Kepuasan Pelanggan Andayani Waroeng Steak N Djawa (Studi Pada Andayani Waroeng Steak N Djawa Di Pamekasan)
Authors: Al Amir Berry Irsyad 
Published: February 2020

Business ethics is a code of conduct employers based on the value - moral values and norms are used as guidance in making decisions and solving problems Zimmerer (1996:20). Menurut Ronald J. Ebert dan Ricky M. Griffin (200:80) Business ethics is a term often used to indicate a person's ethical behavior of managers or employees of an organization.Satisfaction is of feeling happy or disappointed someone who comes from a comparison between the impression of the performance (or result) of a product and hopes (Ronny A. Rusly (2002 : 37)This study aims to determine whether there is influence of the application of business ethics to customer satisfaction in Andayani Waroeng Steak N Java in Pamekasan. The sample collection technique using accidental sampling with analysis of data using multiple linear regression.
Pengaruh Corporate Governance Terhadap Manajemen Laba Di Indonesia
Authors: Monica Laura 
Published: February 2020

Tujuan utama dari penelitian ini adalah meneliti hubungan antara corporate governance, yang diukur dengan kepemilikan manajerial, kepemilikan institusional, kepemilikan asing, dan komisaris independen, terhadap manajemen laba. Dengan menggunakan sampel dari perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia selama periode 2013-2015. Penelitian ini menemukan bukti bahwa kepemilikan manajerial dan kepemilikan asing memiliki pengaruh terhadap manajemen laba, sedangkan kepemilikan institusional dan komisaris independen tidak memiliki pengaruh terhadap manajemen laba.
Diagnostic evaluation of IgM ELISA and IgM Immunofluorescence assay for the diagnosis of Acute Scrub Typhus in central Nepal
Authors: Gautam Rajendra , Parajuli Keshab , Tshokey Tshokey , Stenos John , Sherchand Jeevan Bahadur 
Published: February 2020

Abstract
Introduction Scrub typhus is an acute febrile illness caused by the obligate intracellular bacterium,Orientia tsutsugamushi. Given their affordability and ease of use, antibody based diagnostic assays can be important diagnostic tools for early detection of scrub typhus fever in resource poor countries like Nepal. Immunochromatography (ICT) and IgM ELISA are two of the routinely employed antibody based assays for diagnosis of Scrub typhus fever in Nepal, although the recommended gold standard diagnostic test is IgM Immunofluorescence assay (IFA). This study evaluated the InBios Scrub Typhus Detect™ Immunoglobulin M (IgM) ELISA and IgM Immunofluorescence assays in single serum sample at the time of admission. Methodology Study participants (1585 suspected cases), were enrolled based on acute febrile illness with suspected scrub typhus cases in central Nepal from April 2017 to March 2018. Blood sample was collected from the suspected patients of scrub typhus, presenting with acute febrile illness. IgM antibody to Orientia tsusugamushi was detected by using Scrub Typhus Detect™ Kit (In Bios International, USA) and an in-house IgM IFA (Australian Rickettsial Reference Laboratory, Geelong, Australia. The IFA assay was performed with the Gilliam, Karp, Kato strains and O. chuto antigens following the ARRL protocol. Result Statistical analysis of ELISA IgM results when compared to reference test, IgM IFA results demonstrated the following characteristics, sensitivity 84.0% (95%CI: 79.73%-87.68%), specificity 94.82% (95% CI: 93.43%-95.99%), positive likelihood ratio 16.21% (95% CI: 12.71%-20.67%), negative likelihood ratio 0.17% (95% CI: 0.13-0.21%), disease prevalence 22.08% (95% CI: 20.06%-24.21%), positive predictive value 82.12% (95% CI: 78.28-85.42%) and negative predictive value 95.44% (95% CI: 94.27%-96.38%) respectively. Conclusion The study indicated that the IgM ELISA has the sensitivity 84.0% (95% CI: 79.73%-87.68%) and specificity 94.82% (95% CI: 93.43%-95.99%). Although IgM IFA is considered the gold standard test for the diagnosis of scrub typhus cases, it is relatively expensive, requires trained personal and a microscope with fluorescence filters. Scrub typhus IgM ELISA with appropriate OD cut–off values may be the best alternative test and possible viable option for resource limited endemic countries like Nepal.
A randomized controlled trial study of the acceptability, feasibility, and preliminary impact of SITA (SMS as an Incentive To Adhere): A mobile technology-based intervention informed by behavioral economics to improve ART adherence among youth in Uganda
Authors: MacCarthy Sarah , Wagner Zachary , Mendoza-Graf Alexandra , Gutierrez Carlos Ignacio , Samba Clare , Birungi Josephine , Okoboi Stephen , Linnemayr Sebastian 
Published: February 2020

Abstract
Background: Studies report serious adherence problems among youth (individuals age 15-24 years of age) in Uganda. Recent growth in mobile phone ownership has highlighted the potential of using text-based interventions to improve antiretroviral treatment (ART) adherence among Ugandan youth. We piloted a randomized controlled trial of a text-based intervention providing weekly real-time antiretroviral adherence feedback, based on information from a smart pill box, to HIV-positive Ugandan youth. In this paper, we report the acceptability, feasibility, and preliminary impact of the intervention.
Methods: We randomized participants to a control group, or to receive messages with information on either their own adherence levels (Treatment 1 - T1), or their own adherence and peer adherence levels (Treatment 2 – T2). We conducted six focus groups from December 2016 to March 2017 with providers and youth ages 15-24, double coded 130 excerpts, and achieved a pooled Cohen’s Kappa of 0.79 and 0.80 based on 34 randomly selected excerpts.
Results: The quantitative and qualitative data show that the intervention was deemed acceptable and feasible. After controlling for baseline adherence, the T1 group had 3.8 percentage point lower adherence than the control group (95% CI -9.9, 2.3) and the T2 group had 2.4 percentage points higher adherence than the control group (95% CI -3.0, 7.9). However, there was an increasing treatment effect over time for the T2 group with the largest effect towards the end of the study; a 2.5 percentage point increase in the initial 9-weeks that grows steadily to 9.0 percentage points by the last 9-weeks of the study. We find negative treatment effects for T1 in 3 of the 4 9-week intervals. This pilot study was not designed to detect statistically significant differences.
Conclusions: Improving youth’s adherence by supplementing information about their adherence with information about the adherence of peers is a promising new strategy that should be further evaluated in a fully-powered study. Providing one’s own adherence information alone appears to have less potential.
Serum levels of soluble programmed death-ligand 1 (sPD-L1) in patients with primary central nervous system diffuse large B-cell lymphoma
Authors: Cho Inju , Lee Hansang , Yoon Sang Eun , Ryu Kyung Ju , Ko Young Hyeh , Kim Won Seog , Kim Seok Jin 
Published: February 2020

Abstract
Background

The interaction of programmed death-1 protein (PD-1) and programmed death-1 ligand (PD-L1) produces immunosuppressive activity, protecting tumor cells from anti-tumor immunity and possibly releasing soluble PD-L1 (sPD-L1) from PD-L1 expressing tumor cells. Therefore, we measured serum levels of sPD-L1 in patients with primary central nervous system lymphoma (PCNSL) and explored its clinical implications.

Methods

Sixty-eight patients with newly diagnosed PCNSL had diffuse large B-cell lymphoma and were treated with high-dose methotrexate-containing chemotherapy. The measurement of sPD-L1 and cytokines was performed using serum samples archived at diagnosis, and the tissue expression of PD-L1 was also analyzed from archived paraffin-embedded tissue blocks. Disease relapse, progression-free survival (PFS), and overall survival (OS) were analyzed according to the extent of sPD-L1 in serum and PD-L1 in tissue.

Results

The median level of serum sPD-L1 (0.429 ng/mL) was higher than in healthy control patients (0.364 ng/mL). The occurrence of relapse was more frequent in the high sPD-L1 (78%) than the low sPD-L1 group (50%), though the groups did not have different clinical or pathological characteristics at diagnosis. As a result, the OS and PFS for the high sPD-L1 group were significantly lower than those in the low group. PD-L1-positive tumor cells were found in 35 patients (67%), and the extent of PD-L1-postive tumor cells was positively associated with serum sPD-L1 levels ( r = 0.299, P = 0.031). Among the 34 cytokines analyzed, only the serum level of IL-7 correlated with the serum level of sPD-L1 (r = 0.521, P < 0.001).

Conclusions

Serum levels of sPD-L1 could reflect the expression of PD-L1 in PCNSL tumor cells and predict patient survival outcomes. Therefore, sPD-L1 in serum could be a feasible biomarker for determining a risk-adapted treatment strategy for PCNSL patients.
Puccinia triticina pathotypes-THTT and THTS display complex transcript profiles on Thatcher
Authors: Wei jie , Cui Liping , Du dongdong , Zhang na , Meng qingfang , Yan hongfei , Yang wenxiang 
Published: February 2020

Abstract
Background: Wheat leaf rust is an important disease worldwide. Understanding the Puccinia triticina f.sp tritici (Pt) pathogenic molecular mechanism and inconstant toxic region are highly important for managing the disease. The present study aimed to analyze pathogenic divergences between Pt isolates. Results: Total RNA was extracted from Thatcher infected by two Pt isolates, Tc361_1 (THTT) and Tc284_2 (THTS) at 144 hours post inoculation (hpi). The mRNA then was harvested and sequenced. Results indicated that a total of 2,784 differential expressed genes (DEGs) were detected. Forty-five genes were specifically expressed in THTT including transcription initiation factor, transmembrane transporter activity and so on, while 26 genes were specially expressed in THTS including GTPase activity, ABC transporter and so on. Fifty-four differential expressed candidate effectors were screened from the tow isolates. Two candidate effectors were chosen and validated on tabacco, and the result showed that they can inhibit the necrosis induced by Bax. qRT-PCR of 12 significantly different expressed genes were carried out to prove that the results of RNA-seq is similar to that of qRT-PCR at 144 hpi and show their expression level in the early stage and the difference between two Pt pathotypes.Conclusion: The results obtained in this study showed that the transcript profiles between THTT or THTS and Thatcher were very complicated.
Frequency of thrombophilia associated genes. Population – based study.
Authors: Wawrusiewicz-Kurylonek Natalia , Kretowski Adam Jacek , Posmyk Renata 
Published: February 2020

Abstract
Background: Thrombophilia is a hypercoagulable state that may have a genetic basis (inherited) or can be acquired. It is a multifactorial condition and only the mutual interactions between the environment and genes may lead to the development of clinical manifestation. This state is the main factor promoting venous (rarely arterial) thromboembolism (VTE). Inherited thrombophilia is mainly associated with two pathogenic variants in the V coagulation factor ( FV ) and the prothrombin ( FII ) genes. The aim of our study was to evaluate the frequency of two pathogenic variants in FII and FV genes as inherited thrombophilia factors in a group within the Polish population in comparison with other described populations.
Methods: All studied groups consisted of 633 unrelated patients aged between 18 and 70. Individuals in the research group come from the Podlasie region of Poland. Genotyping of FII and FV variants was performed using the 7900HT Fast Real-Time PCR System and were genotyped by TaqMan assay.
Results: The pathogenic allele frequency for A allele was 0.03 (3%) and 0.07 (7%) for FII and FV genes, respectively. The GA/AA genotypes (c.*97G>A variant) were observed in only 33 (5.03%) individuals in the studied group. Additionally, the frequency of GA/AA genotypes was over 17.4% in the coagulation factor V. Co-incidence of heterozygous genotype GA of variants FII and FV genes was observed in only 4 subjects.
Conclusions: The FII gene variant shown in our study is less frequent than in other European countries (about 6%). In contrast, the A allele of the FV gene occurs with a frequency similar to that of Northern, Central and South Central Europe (about 5%).
Genome-wide analysis of wheat DNA-binding with one finger (Dof) transcription factor genes: evolutionary characteristics and diverse abiotic stress responses
Authors: Liu Yue , Liu Nannan , Deng Xiong , Liu Dongmiao , Li Mengfei , Cui Dada , Hu Yingkao , Yan Yueming 
Published: February 2020

Abstract
Background: DNA binding with one finger (Dof) transcription factors play important roles in plant growth and abiotic stress responses. Although genome-wide identification and analysis of the DOF transcription factor family has been reported in other species, no relevant studies have emerged in wheat. The aim of this study was to investigate the evolutionary and functional characteristics associated with plant growth and abiotic stress responses by genome-wide analysis of the wheat Dof transcription factor gene family. Using the recently released wheat genome database (Results: Using the recently released wheat genome database (IWGSC RefSeq v1.1), we identified 96 wheat Dof gene family members, which were phylogenetically clustered into five distinct subfamilies. Gene duplication analysis revealed a broad and heterogeneous distribution of TaDofs on the chromosome groups 1 to 7, and obvious tandem duplication genes were present on chromosomes 2 and 3.Members of the same gene subfamily had similar exon-intron structures, while members of different subfamilies had obvious differences. Functional divergence analysis indicated that type-II functional divergence played a major role in the differentiation of the TaDof gene family. Positive selection analysis revealed that the Dof gene family experienced different degrees of positive selection pressure during the process of evolution, and five significant positive selection sites (30A, 31T, 33A, 102G and 104S) were identified. Additionally, nine groups of coevolving amino acid sites, which may play a key role in maintaining the structural and functional stability of Dof proteins, were identified. The results from the RNA-seq data and qRT-PCR analysis revealed that TaDof genes exhibited obvious expression preference or specificity in different organs and developmental stages, as well as in diverse abiotic stress responses. Most TaDof genes were significantly upregulated by heat, PEG and heavy metal stresses. Conclusions: The genome-wide analysis and identification of wheat DOF transcription factor family and the discovery of important amino acid sites are expected to provide new insights into the structure, evolution and function of the plant Dof gene family.