bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the peripheral microcirculation in patients with and without shock: a pilot study on different methods
Authors: Filho Roberto Rabello , de Freitas Chaves Renato Carneiro , Assunção Murillo Santucci Cesar , Neto Ary Serpa , De Freitas Flavia Manfredi , Romagnoli Maria Laura , Silva Eliézer , Lattanzio Bernardo , Dubin Arnaldo , Corrêa Thiago Domingos 
Published: November 2019

AbstractMicrovascular dysfunction has been associated with adverse outcomes in critically ill patients, and the current concept of hemodynamic incoherence has gained attention. Our objective was to perform a comprehensive analysis of microcirculatory perfusion parameters and to investigate the best variables that could discriminate patients with and without circulatory shock during early intensive care unit (ICU) admission. This prospective observational study comprised a sample of 40 adult patients with and without circulatory shock (n = 20, each) admitted to the ICU within 24 h. Peripheral clinical [capillary refill time (CRT), peripheral perfusion index (PPI), skin-temperature gradient (Tskin-diff)] and laboratory [arterial lactate and base excess (BE)] perfusion parameters, in addition to near-infrared spectroscopy (NIRS)-derived variables were simultaneously assessed. While lactate, BE, CRT, PPI and Tskin-diff did not differ significantly between the groups, shock patients had lower baseline tissue oxygen saturation (StO2) [81 (76–83) % vs. 86 (76–90) %, p = 0.044], lower StO2min [50 (47–57) % vs. 55 (53–65) %, p = 0.038] and lower StO2max [87 (80–92) % vs. 93 (90–95) %, p = 0.017] than patients without shock. Additionally, dynamic NIRS variables [recovery time (r = 0.56, p = 0.010), descending slope (r = − 0.44, p = 0.05) and ascending slope (r = − 0.54, p = 0.014)] and not static variable [baseline StO2 (r = − 0.24, p = 0.28)] exhibited a significant correlation with the administered dose of norepinephrine. In our study with critically ill patients assessed within the first twenty-four hours of ICU admission, among the perfusion parameters, only NIRS-derived parameters could discriminate patients with and without shock.
Spectral Properties of Highly Emissive Derivative of Coumarin with N,N-Diethylamino, Nitrile and Tiophenecarbonyl Moieties in Water-Methanol Mixture
Authors: Kolbus Anna , Danel Andrzej , Grabka Danuta , Kucharek Mateusz , Szary Karol 
Published: November 2019

AbstractThe new derivative of coumarin (E)-3-[7-(diethyloamino)-2-oxo-chromen-3yl]-2-(tiophene-2-carbonyl)prop-2-enenitrile (NOSQ) was easy synthesized with commercial substrates as a result of the search of new Michael type addition sensors based on coumarins. Spectral properties of highly emissive NOSQ were investigated by steady state analysis (absorption and fluorescence measurements) and time-resolved analysis (fluorescence lifetime measurements). The effect of water-methanol mixture on the photophysical properties of the NOSQ molecule was analyzed. With increasing of volumetric fraction of water the intensity of absorbance and fluorescence was strongly reduced. The NOSQ quantum yield in methanol was quite high and the first portions of water caused a significant increase in this value. Water, which is usually a quencher, in this case caused the increase in the quantum yield. The fluorescence lifetimes had second-order decay and the values of fluorescence lifetime increased with increasing alcohol content. Density functional theory (DFT) calculations and experimental data remained in agreement and showed that the interaction between the NOSQ molecule and the solvent affects the appearance of the new conformer.
Asian Crop Dispersal in Africa and Late Holocene Human Adaptation to Tropical Environments
Authors: Power Robert C. , Güldemann Tom , Crowther Alison , Boivin Nicole 
Published: November 2019

AbstractOccupation of the humid tropics by Late Holocene food producers depended on the use of vegetative agricultural systems. A small number of vegetative crops from the Americas and Asia have come to dominate tropical agriculture globally in these warm and humid environments, due to their ability to provide reliable food output with low labour inputs, as well as their suitability to these environments. The prehistoric arrival in Africa of Southeast Asian crops, in particular banana, taro and greater yam but also sugar cane and others, is commonly regarded as one of the most important examples of transcontinental exchanges in the tropics. Although chronologies of food-producer expansions in Central Africa are increasingly gaining resolution, we have very little evidence for the agricultural systems used in this region. Researchers have recovered just a handful of examples of archaeobotanical banana, taro and sugar cane remains, and so far none from greater yam. Many of the suggested dispersal routes have not been tested with chronological, ecological and linguistic evidence of food producers. While the impact of Bantu-speaking people has been emphasised, the role of non-Bantu farmers speaking Ubangi and Central Sudanic languages who have expanded from the (north)east has hardly been considered. This article will review the current hypotheses on dispersal routes and suggest that transmissions via Northeast Africa should become a new focus of research on the origins of Asian vegeculture crops in Africa.
Contractions of group representations via geometric quantization
Authors: Akylzhanov Rauan , Arnaudon Alexis 
Published: November 2019

AbstractWe propose a general framework to contract unitary dual of Lie groups via holomorphic quantization of their coadjoint orbits, using geometric quantization. The sufficient condition for the contractibility of a representation is expressed via cocycles on coadjoint orbits. This condition is verified explicitly for the contraction of SU$$_2$$2 into $$\mathbb {H}$$H. We construct two types of contractions that can be implemented on every matrix Lie group with diagonal contraction matrix.
Uptake of subsoil water below 2 m fails to alleviate drought response in deep-rooted Chicory (Cichorium intybus L.)
Authors: Rasmussen Camilla Ruø , Thorup-Kristensen Kristian , Dresbøll Dorte Bodin 
Published: November 2019

Abstract
Aims
Deep-rooted agricultural crops can potentially utilize deep soil moisture to reduce periods where growth is water limited. Chicory (Cichorium intybus L.) is a deep-rooted species, but the benefits of deep roots to water uptake has not been studied. The aim of this study was to investigate the value of deep roots (>2 m) under topsoil water limitation.

Methods
Chicory grown in 4 m deep soil-filled rhizotrons was exposed to either topsoil drought or resource competition from the shallow-rooted species ryegrass (Lolium perenne L.) and black medic (Medicago lupulina L.). The effect on deep water uptake was assessed using non-destructive measurements of roots, soil water and tracers.

Results
Water uptake occurred below 1.7 m depth in 2016, and below 2.3 m depth in 2017 and contributed significantly to chicory water use. However, neither surface soil drying nor intercropping increased deep water uptake to relieve water deficit in the shoots.

Conclusion
Chicory benefits from deep-roots during drought events, as it acceses deep soil moisture unavailable to more shallow rooted species, yet deep water uptake was unable to compensate for the reduced topsoil water uptake due to soil drying or crop competition.
Primary hepatocellular adenoma due to biallelic HNF1A mutations and its co-occurrence with MODY 3: case-report and review of the literature
Authors: Fu Junling , Wang Tong , Zhai Xiao , Xiao Xinhua 
Published: November 2019

Abstract
Purpose
Maturity-onset diabetes of the young type 3 (MODY 3) is a consequence of heterozygous germline mutations in HNF1A, and a subtype of hepatocellular adenoma (HCA) is caused by biallelic somatic HNF1A mutations; rare HCA may be related to MODY 3. This study aimed to investigate the cosegregation of HNF1A mutations with diabetes and HCA in two families.

Methods
Two patients suffering from HCA and diabetes were screened for HNF1A germline and somatic mutations using direct sequence analysis and methylation-specific multiplex-ligation-dependent probe amplification (MS-MLPA) assay. Further, we screened eight relatives in the two independent families for diabetes, HCA and HNF1A variants. Additionally, we reviewed the literature concerning the phenotypes of MODY 3 and HCA at the background of HNF1A mutations.

Results
Here we reported two families (a total of six relatives) with two missense germline mutations of HNF1A identified initially using direct sequence analysis (c.686G>A in family A and c.526 + 1G>A in family B). Somatic deletion of the second allele of HNF1A was found in liver tumor tissues in both probands who were diagnosed with HCA. There are a total of ten cases of both MODY 3 and HCA phenotypes reported in the literature to date; incomplete penetrance for HCA was observed, and all the patients with HCA developed diabetes. The onset of diabetes and HCA was highly variable, the treatment of diabetes varied from diet to insulin, and the clinical expression of HCA ranged from silent to hemorrhage. Further, the severity of diabetes mellitus was not related to the occurrence of HCA.

Conclusions
This study describes the association of HCA and MODY 3 at the background of HNF1A mutations and highlights the importance of screening for HCA in MODY 3 families to avoid the possibility of severe complications. Further, the current study indicated that there may be a special mutational spectrum of HNF1A correlated with HCA in MODY 3 families.
In-orbit AIS performance of the Norwegian microsatellites NorSat-1 and NorSat-2
Authors: Eriksen Torkild , Helleren Øystein , Skauen Andreas Nordmo , Storesund Frode A. S. , Bjørnevik Anders , Åsheim Harald , Blindheim Eirik Voje , Harr Jon 
Published: November 2019

AbstractTwo Norwegian AIS-satellites, NorSat-1 and NorSat-2, were launched in July 2017. Both are equipped with the ASR x50, the latest space-AIS receiver developed by Kongsberg Seatex AS, offering advanced signal processing and continuous operation on all four AIS channels. The NorSat-satellites collect ~ 1.5 million messages from ~ 50,000 ships per day (24 h) each, which is a factor ~ 2.8 increase in the number of messages compared to the ASR 100 on-board AISSat-1 and AISSat-2. The improvements of the AIS-satellites can be attributed to three developments: the performance of the receiver, the use of antenna diversity, and the use of frequency channel diversity. Daily statistics for February 2018 over the Mediterranean Sea illustrate the improvements: The median value of the number of messages received with NorSat-1 using only one antenna is 2.3 times higher than for AISSat-1. When both NorSat-1 antennas are used, the improvement factor becomes 4.1, and finally, when two additional receiver channels are used to collect long-range AIS messages, the total improvement becomes 8.2 times. In terms of ships detected, the factors are 1.8, 2.7, and 4.4 for the respective steps. Long-range AIS messages amount to just 5% of the total AIS messages received by NorSat-1 in August 2017, but it allows to detect 20% more ships on a global scale, and as much as 10 times more ships in a the high-traffic area in the North Sea.
Fisheries women groups in Japan: a shift from well-being to entrepreneurship
Authors: Soejima Kumi , Frangoudes Katia 
Published: November 2019

AbstractWomen’s groups in rural fishery areas were established in the mid-1950s. By 1959, they became integrated in local Fishery Cooperative Associations as parallel organizations. These Fisheries Cooperative Associations, established in 1948, represent all fishers in Japan, who are primarily men. The purpose of the women’s groups was to provide well-being by improving the living conditions of families and communities. While men were busy building the production facilities and the cooperatives, women organized themselves to protect and improve the everyday life of families. From 1995 and the World Conference on Women in Beijing, China, some of these women groups ran economic entrepreneurial activities with the financial support of the State through the cooperatives. This new role of women’s groups aims to improve the economic and social development and environment of families and communities facing depopulation problems who need to increase the number of young people. This paper examines the role of cooperative associations in rural, fishery communities and shows how these associations “handed over” the social responsibilities to the women groups who then developed their social skills and competences. Special emphasis is put on how the women groups changed their activity from social issues to environmental protection, promotion of fishery products, and to entrepreneurial activities. The paper also problematizes the difficulties the women met in order to get their contribution to the fisheries communities and industry recognized, as well as their status.
Predictors of Condomless Sex and Sexual Health Behaviors in a Sample of Portuguese Single Adults
Authors: Rodrigues David L. , Lopes Diniz , Pereira Marco , Prada Marília , Garrido Margarida V. 
Published: November 2019

Abstract

Introduction
Several theoretical models and intervention programs overlook the importance of individual motivations for the decision to have condomless sex. For instance, people focused on promotion (ie, eager to pursue pleasure) report less intentions to use condoms, because they perceive a lower risk of acquiring sexually transmitted infections.

Aim
We aimed at understanding to what extent individual motivations are predictive of condomless sex behavior among single individuals.

Methods
A sample of 415 Portuguese individuals (254 women) with ages ranging from 18−46 years (M = 23.30; SD = 5.28) were recruited to a cross-sectional study. All participants were neither dating nor in a romantic relationship at the time of the study. The link to an anonymous web survey was shared in social networking platforms.

Main Outcome Measure
The survey included self-reported demographic variables (eg, age and sex), recent condomless sex behavior, and previously validated measures assessing regulatory focus in sexuality, ability in sexual restraint, perceived control over condom use, perceived safety with sex partners, and salience of the condom use norm.

Results
More than two-thirds of the sample had recently engaged in condomless sex. A logistic regression showed that condomless sex was more likely for participants predominantly focused on promotion in sexuality. It was also more likely among less educated participants, those with a lower ability to restrain their sexual behavior, those who perceive to have less control over condom use, those for whom the condom use norm was less salient, and those who perceived to be safer with their sex partners. No other results were significant.

Clinical Implications
Our results can be informative to sexual health care professionals when planning strategies to increase condom use awareness, by considering the role of specific individual motivations.

Strengths & Limitations
This is the first study showing that individual motivations uniquely contribute to the decision to have condomless sex. This study has 2 main limitations that constraint the generalizability of the findings: (a) cross-sectional data prevents us from establishing causality, and (b) individual data does not account for dyadic processes in sexuality (eg, condom use negotiation).

Conclusion
Our findings showed that condomless sex results from an individual focus on seeking pleasure, a lack of control in sexual behavior, and a perception of sex partners as more trustworthy. Overall, these findings are likely to help researchers and health care professionals improving theoretical models predicting condom use and preventing the spread of sexually transmitted infections.
Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE‐ε4/TOMM40 long poly‐T repeat allele variants
Authors: Prokopenko Inga , Miyakawa Gentaro , Zheng Bang , Heikkinen Jani , Petrova Quayle Daniela , Udeh‐Momoh Chinedu , Claringbould Annique , Neumann Juliane , Haytural Hazal , Kaakinen Marika A. , Loizidou Elena , Meissner Esther , Bertram Lars ,   BIOS consortium, Gveric Djordje O. , Gentleman Steve M. , Attems Johannes , Perneczky Robert , Arzberger Thomas , Muglia Pierandrea , Lill Christina M. , Parkkinen Laura , Middleton Lefkos T. 
Published: November 2019

AbstractIntroductionThe role of TOMM40‐APOE 19q13.3 region variants is well documented in Alzheimer's disease (AD) but remains contentious in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).MethodsWe dissected genetic profiles within the TOMM40‐APOE region in 451 individuals from four European brain banks, including DLB and PDD cases with/without neuropathological evidence of AD‐related pathology and healthy controls.ResultsTOMM40‐L/APOE‐ε4 alleles were associated with DLB (ORTOMM40‐L = 3.61; P value = 3.23 × 10−9; ORAPOE‐ε4 = 3.75; P value = 4.90 × 10−10) and earlier age at onset of DLB (HRTOMM40‐L = 1.33, P value = .031; HRAPOE‐ε4 = 1.46, P value = .004), but not with PDD. The TOMM40‐L/APOE‐ε4 effect was most pronounced in DLB individuals with concomitant AD pathology (ORTOMM40‐L = 4.40, P value = 1.15 × 10−6; ORAPOE‐ε4 = 5.65, P value = 2.97 × 10−8) but was not significant in DLB without AD. Meta‐analyses combining all APOE‐ε4 data in DLB confirmed our findings (ORDLB = 2.93, P value = 3.78 × 10−99; ORDLB+AD = 5.36, P value = 1.56 × 10−47).DiscussionAPOE‐ε4/TOMM40‐L alleles increase susceptibility and risk of earlier DLB onset, an effect explained by concomitant AD‐related pathology. These findings have important implications in future drug discovery and development efforts in DLB.
Viability of joined flight for small unmanned aerial vehicles
Authors: Levis E. , Pleho F. , Hedges J. 
Published: November 2019

ABSTRACTThe range of small, electrically powered UAVs is still limited by the mass specific energy of batteries. This paper investigates the idea that, in cases where multiple aircraft must transit to the same location, savings in mass or an extension of achievable range are possible when they join wingtip-to-wingtip. The viability of joined flight is investigated by quantifying the relative magnitude of savings resulting from increased aerodynamic efficiency and that of penalties due to the increased structural and component weights. Through a parametric analysis the level of savings achievable is found to be greatly dependent on the proportion of the flight spent in a joined configuration and aircraft design parameters such as wing loading, aspect ratio and the added weight of the joining mechanism. A custom, multidisciplinary UAV sizing algorithm is presented and utilised to design several sample aircraft, featuring two different joining mechanism architectures. The results verify the findings of the parametric study and indicate that mass savings are possible only for moderate to low aspect ratios, with semi-permanent magnetic joining mechanism performing better than rigid structural ones, even when the joined fight segment accounts for only 30% of the total airborne time.
Decontextualized talk in caregivers’ input to 12-month-old children during structured interaction
Authors: GRIMMINGER Angela , ROHLFING Katharina J. , LÜKE Carina , LISZKOWSKI Ulf , RITTERFELD Ute 
Published: November 2019

AbstractDecontextualized talk is assumed to be used only rarely when children are younger than 30 months. Motivated by Bühler's (1934/1999) linguistic theory that describes different dimensions of (de-)contextualization, we provide evidence that this kind of input can already be found in caregivers’ talking to their 12-month-old children. Such early input is characterized by being decontextualized on some dimensions while being grounded in the immediate context on others. In this way, parents may scaffold understanding of talk about the there-and-then. We also examined whether caregivers adapt decontextualized verbal input to individual trajectories in language development. We observed 59 parent–child interactions within a decorated room when children were 12 months old, and assessed the children's linguistic development at 12 and 24 months of age. However, we did not find differences in the input directed toward children with different trajectories in language development.
A cone beam CT-based study on fiducial seed migration and planning target volume margin in prostate radiotherapy
Authors: Thuruthiyil Divya K. , Cawley Martin , Metwaly Mohamed 
Published: November 2019

AbstractAim:This study attempts to investigate fiducial marker (FM) migration and calculate the prostate planning target volume (PTV) margin considering the setup errors after translation corrections alone (T) and translation plus rotational corrections (T+R) and anatomy variation with respect to the corrected fiducial position, analysed on cone beam computed tomography (CBCT) images.Methods and materials:CBCT images from 25 patients are analysed for FM movements, setup error and anatomy variation with respect to the seed match positions. Systematic and random components of setup error and prostate movements are used to calculate the PTV margin for CBCT-based FM localisation in two scenarios, translation corrections only and translation plus rotational correction. MTNW887825 soft tissue gold markers (Civco, Orange City, FL, USA) were used with the department-specific immobilisation system and rectal and bladder filling protocols.Results:The average directional inter-marker distance variation is −0·05 ± 0·90 mm. The systematic setup errors for T+R are 0·40, 0·63 and 0·80 mm in right–left (RL), anterior–posterior (AP) and superior–inferior (SI), respectively. The corresponding values for T only are 0·54, 0·69 and 0·90 mm. The systematic prostate movement from T+R corrected FM positions are 0·65, 1·27 and 1·32 mm in the RL, AP and SI directions.Findings:Minimal FM movements are noted from the study. The PTV margins to incorporate the daily T+R corrected setup error and prostate deformation are found to be 2·5, 4·5 and 5·2 mm in the RL, AP and SI directions, respectively. The corresponding margins for T only corrected scenario are found to be 2·8, 4·8 and 5·7 mm.
First SWARM Observations of the Artificial Ionospheric Plasma Disturbances and Field‐Aligned Currents Induced by the SURA Power HF Heating
Authors: Lukianova R. , Frolov V. , Ryabov A. 
Published: November 2019

AbstractA series of experiments were conducted with a conjunction between the midlatitude SURA ionospheric heating facility and the multisatellite SWARM mission. We present the first observations made by SWARM on the plasma perturbations and electric currents induced in the F2 region ionosphere by the high‐power high‐frequency O‐mode radio wave pumping. In the heated region, significant effects include a localized increase of the electron temperature accompanied by stratification of the electron density and the magnetic signatures of field‐aligned currents (FACs). The spatial structure and amplitude of FACs indicate that the current system is likely associated with the unipolar diffusion and excitation of eddy electric currents in the ionosphere. Similar effects are revealed in the laboratory experiment but not previously observed in space.