bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pé, de Sławomir Mrożek, e A Armadilha, de Tadeusz Różewicz: Drama, Testemunho, Memória e Tradução
Authors: Paiva de Souza Marcelo 
Published: January 2021

Em um plano teórico mais amplo, a matéria sob escrutínio neste artigo é o teatro como um medium artístico sui generis de testemunho e memória da Shoah (conforme estudiosos como Robert Skloot e Grzegorz Niziołek, entre outros). Aborda-se a questão contra o pano de fundo das realizações de encenadores e dramaturgos poloneses desde o imediato pós-guerra até os dias de hoje – riquíssimo acervo criativo ainda vastamente desconhecido no Brasil. Para efeito de exemplificação e exame de aspectos específicos do problema, duas peças fundamentais, ainda sem tradução em português, são objeto de comentário e discussão um pouco mais detidos: Pieszo (A pé; 1980), de Sławomir Mrożek, e Pułapka (A armadilha; 1982), de Tadeusz Różewicz.
Cuerpos diversos, Tetas Diversas. Acción artística para sensibilizar en igualdad de género y diversidad sexual a través de la cerámica
Authors: Ramon Ricard , Alonso-Sanz Amparo 
Published: January 2021

En este fotoensayo, presentamos el desarrollo de la acción
Tetas Diversas
, realizada durante el mes de octubre de 2020 con alumnado del Grado de Maestro/a en Educación Primaria de la Facultad de Magisterio de la Universitat de València. Esta acción forma parte de un proceso de investigación para analizar y valorar el papel de las acciones artísticas en los procesos de sensibilización respecto a cuestiones de identidad de género y diversidad sexual. La experiencia consiste en la reflexión sobre la diversidad de nuestros cuerpos desde una mirada ecofeminista para reivindicar la necesidad de una institución más humanizada, naturalizada, igualitaria, respetuosa con la diversidad e inclusiva. Esta reflexión encarnada emplea el modelado de macetas de barro antropomorfas inspiradas en los trabajos de la artista Emma Low como forma de enfrentarnos a las experiencias personales de nuestro cuerpo. Los resultados consisten en múltiples acciones de sensibilización a través de la entrega de micro relatos que acompañan a estos objetos a personal docente e investigador o de administración y servicios de la Universidad.
An international comparison of incentives for earnings management in order to meet analysts forecasts
Authors: Jarne Jarne José Ignacio , Callao Gastón Susana 
Published: January 2021

Una comparación internacional del incentivo para manipular el resultado con el objetivo de alcanzar los pronósticos de los analistas.
Investigaciones previas han evidenciado que cuando los resultados alcanzan, o superan, los pronósticos de los analistas, el mercado reacciona positivamente, mientras que, cuando dichos pronósticos no son alcanzados, la reacción del mercado es la contraria. Por ello, los pronósticos se convierten en metas a batir y, tal como la literatura ya ha contrastado, surge un incentivo para la manipulación del resultado.
En este contexto, el presente trabajo va más allá, evidenciando que la reacción positiva o negativa es de diferente magnitud según los mercados y que ello explica que la fuerza con la que las empresas perciben el incentivo a manipular los resultados para alcanzar dichos pronósticos también sea diferente según el mercado en el que cotiza. Comparando seis mercados, obtenemos que el incentivo es más potente cuanto mayor es el premio por cumplir los pronósticos, o la penalización por no hacerlo.
Previous investigations have shown that when earnings meet analysts’ forecasts, the market reacts positively, and when these forecasts are not reached, the market reacts negatively. For this reason, forecasts become goals to beat, and as the literature has revealed, this creates an incentive for earnings management.
The present paper extends prior research, providing evidence that the magnitude of the reward (penalty) for companies meeting (failing to meet) earnings forecasts differs depending on the market. In addition, it reveals that the strength of the incentive for companies to manage their earnings differs depending on the market in which they are listed. We compare six stock markets and find that the most powerful incentives arise when the reward for meeting the forecasts or the penalty for not doing so is greater.
CAE Remuneration and Financial Reporting Quality
Authors: Alzeban Abdulaziz 
Published: January 2021

Remuneración del Director Ejecutivo de la Auditoría y Calidad de la Información Financiera.
En este trabajo se explora la relación entre la remuneración fija pagada al Director Ejecutivo de Auditoría (CAE) y la consiguiente calidad de la información financiera (FRQ). Así, se argumenta que una estrategia de remuneración basada en el rendimiento de la empresa es perjudicial para la FRQ, y que cuando el CAE recibe una remuneración fija, hay menos amenazas para la objetividad de la auditoría interna (IA) y, por lo tanto, una mayor FRQ como aproximación a la calidad de los informes financieros. Los datos se obtienen a través de una encuesta, y la información se recoge de los informes anuales. Los resultados indican que cuando el CAE es compensado de acuerdo con el desempeño de la empresa, la objetividad se reduce, con el consiguiente resultado de que la FRQ se ve afectada. Además, cuando la remuneración y compensación del CAE es aprobada por el comité de auditoría, en lugar de por el CEO, la FRQ es mayor. También se encuentran pruebas de que los efectos de la objetividad de la IA se eliminan cuando el CEO participa en la aprobación de la remuneración y compensación del CAE. El estudio aporta ideas sobre la cuestión de si la remuneración del CAE mejora la objetividad de la IA y, al hacerlo, es de interés para los comités de auditoría con responsabilidad en esa dirección. Se utilizan dos métodos de estimación diferentes para confirmar la solidez de los resultados.
This paper reports on a study exploring the relationship between the fixed remuneration paid to the Chief Auditing Executive (CAE), and the subsequent financial reporting quality (FRQ). The study argues from the viewpoint that a strategy of compensation provided on the basis of company performance is detrimental to FRQ, and that when the CAE receives fixed remuneration, there is less threat to internal audit (IA) objectivity, and hence, greater FRQ as proxied by accruals quality. Data are obtained via a survey questionnaire, and information offered within annual reports. The findings indicate that when the CAE is compensated according to company performance, objectivity is reduced, with the consequent outcome that FRQ is impaired. Furthermore, when CAE remuneration and compensation are approved by the audit committee, rather than by the CEO, FRQ is higher. Evidence that the effects of IA objectivity are eliminated when the CEO is involved in approving CAE remuneration and compensation is also found. The study provides insights into the question of whether CAE remuneration enhances IA objectivity, and in doing so is of interest to audit committees with responsibility in that direction. Two different estimation methods are used as a means of confirming the robustness of these results.
Patient Preferences for Time and Location of Infusible Therapies in Multiple Sclerosis and Neuroimmunologic Disorders
Authors: Rath Louise , Campagna Maria Pia , Stankovich Jim , Ellis Julian , Jokubaitis Vilija , McCarthy Denise , Nesbitt Cassie , Yeh Wei Zhen , Zhong Michael , Wesselingh Robb , Monif Mastura , Richards Janene , Minh Viet Bui , Skibina Olga , Butzkueven Helmut , van der Walt Anneke 
Published: January 2021

Abstract

Background:
People with multiple sclerosis and neuroimmunologic disorders (herein referred to as patients) are increasingly treated with infusible monoclonal antibodies. This rise in demand has placed increased loads on current infusion services and mandates careful strategic planning. This study examined patient preferences for the timing and location of infusions and their association with demographic and disease variables to facilitate patient-focused strategic planning.

Methods:
Ninety-one patients receiving an infusible therapy at an infusion service during March 2019 were asked to complete a questionnaire exploring eight domains, including preferences for time of infusions and location of infusion centers. Potential access to home-based treatment was included as an option. Unstructured (free-text) feedback on current service was also obtained.

Results:
Eighty-three patients completed the survey (mean age, 42 years; 75% women). Infusions were predominantly natalizumab (66%) and ocrelizumab (25%). Of these patients, 71% were engaged in some form of work or study, and 83% of this group had to arrange time off from work or study to attend treatment. Seventy percent of patients would prefer their infusion before noon, and 60% would consider home-based infusions. Most used a car as their transport to the infusion service.

Conclusions:
These results suggest that patients are more likely to prefer infusible treatment in the morning and are open to home-based infusions. This study provides information for health services to target service delivery at peak preference times and consider alternate ways of delivering infusible treatments.
In vitro anticandidal activity and gas chromatography-mass spectrometry (GC-MS) screening ofVitex agnus-castusleaf extracts
Authors: Ababutain Ibtisam Mohammed , Alghamdi Azzah Ibrahim 
Published: January 2021

BackgroundCandida infections are becoming more drug resistant; it is necessary to search for alternative medications to treat them. Therefore, the present study estimates the anticandidal activity ofVitex agnus-castus(VA-C) leaf extracts.MethodsWe used the agar well diffusion method to assess the anticandidal activity of three different VA-C leaf extracts (ethanol, methanol, and water) against threeCandidaspecies (Candida tropicalis,Candida albicans, andCandida ciferrii). The minimum inhibitory concentration (MIC) was estimated using the two-fold dilution method and the minimum fungicidal concentration (MFC) was determined using the classic pour plate technique. The MFC/MIC ratio was calculated to estimate the microbicidal or microbiostatic activity. A gas chromatography mass spectrometer was used to screen the phytochemicals of the VA-C leaf extracts (ethanol, methanol, and water).ResultsAll VA-C extracts ethanol, methanol, and water were significantly inhibited the growth of the testCandidaspecies and the inhibition activity depended on the solvent used and theCandidaspecies. The results showed thatC. tropicaliswas the most highly inhibited by all extracts followed byC. albicansandC. ciferrii. The MIC values were 12.5–25 µg/ml, and MFC values were 25–100 µg/ml. The ratios of MFC/MIC were two-fold to four-fold which was considered candidacidal activity. Ninety-five phytochemical compounds were identified by the GC-MS assay for the VA-C leaf extracts. The total number of compounds per extract differed. Methanol had 43 compounds, ethanol had 47 compounds, and water had 52 compounds. The highest compound concentrations were: 4,5-Dichloro-1,3-dioxolan-2-one in ethanol and methanol, 1H-Indene, 2,3-dihydro-1,1,2,3,3-pentamethyl in ethanol, Isobutyl 4-hydroxybenzoate in methanol, and Benzoic acid and 4-hydroxy- in water. These phytochemical compounds belong to different bioactive chemical group such as polyphenols, fatty acids, terpenes, terpenoids, steroids, aldehydes, alcohols, and esters, and most of which have anticandidal activity.ConclusionsVA-C leaf extracts may be useful alternatives to anticandidal drugs, based on their effectiveness against all testCandidaspecies at low concentrations. However, appropriate toxicology screening should be conducted before use.
Nothing New: Referencing, Remixing and Sampling
Authors: Burn Graham , Crawford James , Turner Alexander 
Published: January 2021

AbstractLiverpool and London practice Studio MUTT's Graham Burn, James Crawford and Alexander Turner contend that the current age of unpredictable transition is not the time for pseudo‐radical newness. Instead, they evoke the concept of the ‘sample’ as their mode of creative architectural practice, propounding it as an appropriate modus operandi for the contemporary political, pandemic and dwindling neo‐liberal condition.
Metformin Mediated PD‐L1 Downregulation in Combination with Photodynamic‐Immunotherapy for Treatment of Breast Cancer
Authors: Hu Chuan , He Xueqin , Chen Yuxiu , Yang Xiaotong , Qin Lin , Lei Ting , Zhou Yang , Gong Tao , Huang Yuan , Gao Huile 
Published: January 2021

AbstractIntelligent nanomaterials open up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of simple enzymatically cleavable self‐delivery nanoparticles (MA‐pepA‐Ce6 NPs) is developed by conjugating acidic‐sensitive small‐molecule programmed cell death ligand 1 (PD‐L1) inhibitor (Metformin, MET) with photosensitizer (chlorin e6, Ce6) through matrix metalloproteinase‐2 (MMP‐2) cleavable peptide (GPLGVRGDK, pepA). Noticeably, these self‐delivery peptide‐based NPs can circumvent the controversial biosafety facing nanomaterials. Moreover, MA‐pepA‐Ce6 NPs are degraded by overexpressed MMP‐2 in tumor microenvironment (TME) and expose the VRGDK‐Ce6. The exposed VRGDK‐Ce6 shows superior targeting ability towards integrin αvβ3 receptor, ensuring sufficient accumulation and laser‐activated robust antitumor immune effects. Remarkably, the released MET in tumor microenvironment hampers the PD‐L1 expression and augments the antitumor immune response elicited by photodynamics therapy (PDT), thus significantly improving therapeutic outcomes. Overall, this study offers a potential appealing paradigm of synergistic PDT‐triggered immunotherapy by revealing MET‐mediated PD‐L1 downregulation to achieve tumor eradication.
Integrated Devices for Non‐Invasive Diagnostics
Authors: Ates Hatice Ceren , Brunauer Anna , von Stetten Felix , Urban Gerald A. , Güder Firat , Merkoçi Arben , Früh Susanna Maria , Dincer Can 
Published: January 2021

Abstract“Sample‐in‐answer‐out” type integrated diagnostic devices have been widely recognized as the ultimate solution to simplify testing across healthcare systems. Such systems are equipped with advanced fluidic, mechanical, chemical, biological, and electronic components to handle patient samples without any manual steps therefore have the potential to accelerate intervention and improve patient outcomes. In this regard, the combination of integrated devices and non‐invasive sampling has gained a substantial interest to further improve the comfort and safety of patients. In this Review, the pioneering developments in integrated diagnostics are covered and their potential in non‐invasive sampling is discussed. The key properties of possible sample types are highlighted by addressing their relevance for the clinical practice. Last, the factors affecting the transition of integrated devices from academia to the market are identified by analyzing the technology readiness levels of selected examples and alternative remedies are explored to increase the rate of survival during this transition.
SEV‐Net: Residual network embedded with attention mechanism for plant disease severity detection
Authors: Zhao Yun , Chen Jiagui , Xu Xing , Lei Jingsheng , Zhou Wujie 
Published: January 2021

SummaryEarly and accurate assessment of plant disease severity is key to preventing disease attack. Traditional detection methods rely on manual vision to distinguish between types of disease infection, but this is time consuming, laborious and inaccurate. To address this problem, this paper proposes a deep learning‐based attentional network model (SEV‐Net) for plant disease severity identification and classification. The network embeds the improved channel and spatial attention module into the residual block of ResNet. The proposed attention module reduces the redundancy of information between channels and focuses on the most information‐rich regions of the feature map. In this experiment, SEV‐Net achieved an accuracy of 97.59% and 95.37% for multiple and single plant (Tomato) disease severity classification, which was better than existing attentional networks (SE‐Net and CBAM). Moreover, the combination of visualization techniques showed that SEV‐Net was adept at distinguishing small variations between plant diseases, proving the feasibility and effectiveness of the network. Furthermore, we have also designed and developed an Android application for real‐time classification of plant disease severity. The system deploys the SEV‐Net network model, which has higher classification accuracy and faster recognition speed.
A multi‐agent system based for solving high‐dimensional optimization problems: A case study on email spam detection
Authors: Mohammadzadeh Hekmat , Gharehchopogh Farhad Soleimanian 
Published: January 2021

SummaryThere exist numerous high‐dimensional problems in the real world which cannot be solved through the common traditional methods. The metaheuristic algorithms have been developed as successful techniques for solving a variety of complex and difficult optimization problems. Notwithstanding their advantages, these algorithms may turn out to have weak points such as lower population diversity and lower convergence rate when facing complex high‐dimensional problems. An appropriate approach to solve such problems is to apply multi‐agent systems (MASs) along with the metaheuristic algorithms. The present paper proposes a new approach based on the MASs and the concept of agent, which is named MAS as Metaheuristic (MAMH) method. In the proposed method, several basic and powerful metaheuristic algorithms are considered as separate agents, each of which sought to achieve its own goals while competing and cooperating with others to achieve the common goals. Altogether, the proposed method was tested on 32 complex benchmark functions, the results of which indicated the effectiveness and powerfulness of the proposed method for solving high‐dimensional optimization problems. In addition, in this paper, the binary version of the proposed method, called Binary MAMH (BMAMH), was implemented on the email spam detection. According to the results, the proposed method exhibited a higher degree of precision in the detection of spam emails compared to other metaheuristic algorithms and methods.
The power of zebrafish models for understanding the co‐occurrence of craniofacial and limb disorders
Authors: Truong Brittany T. , Artinger Kristin B. 
Published: January 2021

SummaryCraniofacial and limb defects are two of the most common congenital anomalies in the general population. Interestingly, these defects are not mutually exclusive. Many patients with craniofacial phenotypes, such as orofacial clefting and craniosynostosis, also present with limb defects, including polydactyly, syndactyly, brachydactyly, or ectrodactyly. The gene regulatory networks governing craniofacial and limb development initially seem distinct from one another, and yet these birth defects frequently occur together. Both developmental processes are highly conserved among vertebrates, and zebrafish have emerged as an advantageous model due to their high fecundity, relative ease of genetic manipulation, and transparency during development. Here we summarize studies that have used zebrafish models to study human syndromes that present with both craniofacial and limb phenotypes. We discuss the highly conserved processes of craniofacial and limb/fin development and describe recent zebrafish studies that have explored the function of genes associated with human syndromes with phenotypes in both structures. We attempt to identify commonalities between the two to help explain why craniofacial and limb anomalies often occur together.
The mitigating effect of governance quality on the finance‐renewable energy‐growth nexus: Some international evidence
Authors: Kassi Diby Francois , Li Yao , Dong Zhankui 
Published: January 2021

AbstractThis study analyses the conditional effect of governance quality on the finance‐renewable energy‐growth nexus in 123 countries from 1990 to 2017. We built composite indexes of financial development and governance quality through the principal component analysis (PCA) using several financial variables and governance indicators. We employed the generalized method of moments (GMM) and the two‐stage least squares (2SLS) techniques, but also the Granger non‐causality in Dumitrescu and Hurlin (2012). First, the disaggregated analysis shows that renewable energy consumption, financial inclusion, financial efficiency, and financial stability have positive marginal effects on economic growth under a good governance quality, except for financial depth. Second, the aggregated analysis confirms the positive marginal impact of financial development on growth only in low‐income economies, whereas renewable energy consumption has positive marginal effects only in lower‐middle‐income and upper‐middle‐income economies. Finally, the results of the causality analysis differ among countries. Overall, governance quality has a threshold effect on the finance‐renewable energy‐growth nexus, which varies across countries. Accordingly, our study suggests more improvements in the governance quality in these countries, especially in the low‐income and high‐income countries, to enhance the marginal impacts of financial development and renewable energy consumption on growth.
Order book price impact in the Chinese soybean futures market
Authors: Jin Muzhao , Kearney Fearghal , Li Youwei , Yang Yung Chiang 
Published: January 2021

AbstractWe study the price impact of order flow in the world's largest soybean meal futures markets. Our intraday results indicate that incoming orders can be used to explain and predict future price changes. Our results are shown to be robust to various order flow measures, price aggregation approaches and data frequencies. We find that order flow imbalance (OFI) is a more all‐encompassing measure carrying greater information about price change relative to both trade imbalance (TI) and volume. Moreover, while both OFI and TI are shown to predict future price changes, this predictability diminishes over longer measure and price change frequency horizons.
Perineal urethrostomy with combined buccal mucosal graft and skin flap after complete loss of anterior urethra
Authors: Akagi Naoki , Kanematsu Akihiro , Yamamoto Shingo 
Published: January 2021

IntroductionWe report a novel perineal urethrostomy procedure for complete loss of anterior urethral tissue.Case presentationA 74‐year‐old man had complete necrosis of the corpus spongiosum and corpora cavernosa after repeated transurethral surgical procedures. He had been managed with a suprapubic cystostomy tube for 10 years. A perineal urethrostomy was performed, and a posterior wall with an inverted U‐shaped perineal skin flap and an anterior wall with a buccal mucosal graft were created. Five months later, an internal urethrotomy was required for mild anastomotic stenosis. Thereafter, an indwelling Foley catheter was used for urine drainage at night to prevent restenosis of the neourethra and avoid excessive nocturia due to low capacity of the long‐time disused bladder, and the patient became catheter‐free during the daytime.ConclusionThe method presented here is a reasonable option for patients lacking whole anterior urethral tissue.