bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Cap Thickness on Corneal Curvature and Corneal Biomechanics After SMILE: A Prospective, Contralateral Eye Study
Authors: Wu De , Liu Chunlei , Li Bin , Wang Diya , Fang Xuejun 
Published: February 2020

PURPOSE:
To evaluate the impact of cap thickness for small incision lenticule extraction (SMILE) on changes in corneal curvature and biomechanics.

METHODS:
One hundred eyes (50 patients) were enrolled in this prospective contralateral eye study. The difference in manifest refraction spherical equivalent (MRSE) in the same patient was less than 0.50 diopters. SMILE was performed with a randomized cap thickness of 110 µm in one eye and 140 µm in the other eye. MRSE, uncorrected distance visual acuity (UDVA), and corneal curvature and biomechanics were evaluated. The anterior and posterior surfaces of the corneal curvature (mean keratometry [Km] values 2, 4, and 6 mm from the pupil center) were measured by Pentacam HR (Oculus Optikgeräte, Wetzlar, Germany) and changes in corneal biomechanics at 6 months postoperatively by Scheimpflug technology.

RESULTS:

There was no significant between-group difference in UDVA or MRSE postoperatively. Postoperative changes in Km at the anterior surface (ΔKm-ant) in the 4-mm zone were significantly higher in the 110-µm group than in the 140-µm group at 1 day and 1, 3, and 6 months postoperatively (
P
= .043, .045, .003, and .049, respectively); at 3 months, the ΔKm-ant in the 6-mm zone was higher in the 110-µm group (
P
= .035). The changes in second appla-nation time, deformation amplitude, and integrated radius were significantly less in the 110-µm group (
P
= .031, .049, and < .001, respectively).

CONCLUSIONS:
A thicker corneal cap caused less change in anterior surface curvature after SMILE for moderate or low myopia, with no significant difference in UDVA and MRSE.

[
J Refract Surg
. 2020;36(2):82–88.]
An Alternative Wavefront Reconstruction Method for Human Eyes
Authors: Gatinel Damien , Rampat Radhika , Dumas Laurent , Malet Jacques 
Published: February 2020

PURPOSE:
To expand upon and clinically demonstrate the results of a new polynomial decomposition method.

METHODS:
To discuss the theoretical considerations comparing the qualitative and quantitative information produced by the Zernike coefficients and a new polynomial decomposition basis, in a comparative series of theoretical and clinical case studies.

RESULTS:
These comparative studies validate the novel polynomial basis that decomposes the wavefront, with clear segregation of the higher and lower aberrations. There is no artifactual reduction of some of the higher order aberration coefficients, providing a more clinically relevant retinal image quality prediction.

CONCLUSIONS:
Some of the inherent limitations of the Zernike polynomials in clinical ophthalmic applications can be solved by a novel set of polynomials forming an alternative higher order basis. The new basis provides a clear separation between modes containing lower order terms versus higher order terms and offers clinicians a more clinically realistic wavefront analysis.

[
J Refract Surg
. 2020;36(2):74–81.]
Herziening ten voordele van de gewezen verdachte als buitengewoon rechtsmiddel
Authors: Nan J.S. (Joost) 
Published: February 2020

Herziening ten voordele van de gewezen verdachte als buitengewoon rechtsmiddel
Herziening ten voordele van de gewezen verdachte is een bijzonder rechtsmiddel in het gesloten stelsel van rechtsmiddelen. Onder meer op grond van een novum kan, bij hoge uitzondering, een onherroepelijke veroordeling alsnog ongedaan worden gemaakt. De regeling heeft in 2012 diverse wijzigingen ondergaan. Daarbij is het novumcriterium verruimd en is de mogelijkheid ingevoerd dat de procureur-generaal een nader onderzoek verricht naar het mogelijke bestaan van een novum. De Adviescommissie afgesloten strafzaken (ACAS) adviseert hem veelal over de wenselijkheid van dergelijk onderzoek. Het wettelijke novumcriterium en de taakopvatting van de ACAS zijn echter geen rustig bezit gebleken. Er wordt doorlopend voorgesteld om het novumcriterium verder te verruimen en om de ACAS breder naar afgesloten zaken te laten kijken. Het is de vraag of de wetgever aan die oproep gehoor moet geven.
De rechtspositie van de raadsman tijdens het politieverhoor
Authors: Verbaan J.H.J. (Joost) , Hollander L.E. (Laura) 
Published: February 2020

De rechtspositie van de raadsman tijdens het politieverhoor
Dit artikel bespreekt de rechtspositie van de raadsman tijdens het politieverhoor. De advocaat heeft sinds de uitspraak in de zaak Salduz/Turkije het recht voorafgaand aan het politieverhoor aanwezig te zijn bij het verhoor. Het recht tot rechtsbijstand strekt zich ook uit tot aanwezigheid tijdens het verhoor. De invulling van dat rechtsbijstandsrecht tijdens het verhoor is geregeld in het Besluit inrichting en orde politieverhoor. De auteurs bespreken in dit artikel de houdbaarheid van die regeling. Uitspraken van het Europees Hof voor de Rechten van de Mens (EHRM) lijken te suggereren dat deze invulling te eng is.
Mensenhandel, uitbuiting en de Hoge Raad: een overzicht en waardering
Authors: Esser L.B. (Luuk) 
Published: February 2020

Mensenhandel, uitbuiting en de Hoge Raad: een overzicht en waardering
De Hoge Raad drukt de laatste vier jaar een belangrijk stempel op de reikwijdte van de strafbaarstelling van mensenhandel, die is opgenomen in artikel 273f Sr. Zo heeft hij het wetsartikel in belangrijke mate afgebakend door in een deel van de delictsomschrijvingen het bestanddeel ‘uitbuiting’ in te lezen. Wat zijn de implicaties van de door de Hoge Raad gekozen oplossingsrichting en hoe kunnen de door hem gemaakte keuzes worden gewaardeerd?
Noodweer bij eenvoudige mishandeling: vrijspraak of OVAR?
Authors: Quak P.C. (Perry) 
Published: February 2020

Noodweer bij eenvoudige mishandeling: vrijspraak of OVAR?
Deze bijdrage bespreekt de vraag tot welke einduitspraak de strafrechter, bij een geslaagd beroep op noodweer bij ‘eenvoudige mishandeling’, moet komen volgens het schema van artikel 352 Sv. Moet dat zijn: vrijspraak van het ten laste gelegde feit (art. 352, lid 1 Sv) of ontslag van alle rechtsvervolging (art. 352, lid 2 Sv)?
De uitzondering bevestigd: het ne bis in idem-beginsel in recente rechtspraak van de Hoge Raad in het licht van de ratio van het ne bis in idem-beginsel en vanuit Europees perspectief
Authors: Albers W. (Willemijn) , de Groot T.M. (Tessa) 
Published: February 2020

De uitzondering bevestigd: het ne bis in idem-beginsel in recente rechtspraak van de Hoge Raad in het licht van de ratio van het ne bis in idem-beginsel en vanuit Europees perspectief
Deze bijdrage bespreekt recente rechtspraak van de Hoge Raad inzake het ne bis in idem-beginsel na het Alcoholslotprogramma-arrest. Hieruit blijkt dat dat een vergelijking met dit arrest niet opgaat en dat het arrest een uitzonderingspositie in blijft nemen. Ook wordt de rechtspraak beschouwd en gewaardeerd in het licht van de ratio van het ne bis in idem-beginsel en vanuit Europees perspectief. Geconcludeerd wordt dat de nadruk, zowel in nationale als in Europese context, (steeds meer) lijkt te liggen op evenredige bestraffing bij cumulatie van procedures, zodat recht wordt gedaan aan de materiële grondslag van het ne bis in idem-beginsel.
The effectiveness of cognitive training on improving cognitive function and sleep quality in community-dwelling elderly in Iran
Authors: Keramtinejad Maryam , Azadi Arman , Taghinejad Hamid , Khorshidi Ali 
Published: February 2020

Background and aim Given the ever-increasing of the older adults population and in order to achieve healthy and active ageing goals and improvement in the cognitive function and sleep quality in older adult, this study aimed to evaluate the effect of cognitive training program on improving cognitive function and ageing-related sleep quality in community-dwelling elderly in Iran, in 2018.
Methods This was an experimental study. The sample comprised 420 older adults who were a member of the comprehensive health center in one of the southern cities of Iran. 164 had a cognitive problem and sleep disorder, of whom 108 were selected by the available method and based on inclusion criteria. Participants were randomly allocated to an experimental group (n=54) and a control group (n=54). Experimental group samples were undergoing the intervention for two months. Data were collected using MMSE questionnaire, Pittsburgh sleep quality, insomnia severity index and Clinical Dementia Rating Scale (CDR). Data were collected one month before-and-after the intervention. Data were analyzed using SPSS software.
Results There was no significant difference between the mean score of cognitive function and sleep quality in both the intervention group and the control group before the intervention (p>0.05). At the post-test, the mean (SD) of elderly adults’ cognitive function in the intervention and control groups were 2.7 (1.3) and 3.44 (1.7), respectively (p=0.017). Moreover, the mean (SD) of sleep quality in older adults in the intervention and the control group was 6.76 (2.3) and 9.25 (2.36), respectively (p<0.001).
Conclusion Given the obtained results in the current study the cognitive training promotes cognitive function and sleep quality in older adults. Therefore, since this program is effective, low-cost and applicable, it can be used to improve cognitive function and sleep disorder in the older adult population.
Increase in the frequency of obstructive sleep apnea in elderly people
Authors: Ernst Glenda , Mariani Javier , Blanco Magali , Finn Barbara , Salvado Alejandro , Borsini Eduardo 
Published: February 2020

BACKGROUND The prevalence of obstructive sleep apnea (OSA) increases with age. However, older adults have limited perception of the symptoms related with poor sleep quality.
Objectives To know the frequency and characteristics of age-related OSA in a large population with clinical suspicion of sleep apnea.
Methods We conducted a retrospective study. OSA was studied by respiratory polygraphy (RP). Patients were grouped by age (G): GI was between 18-45; GII: 46-65 and GIII > 65 years old. Other demographic characteristics, symptoms and RP indicators were compared. Epworth Sleep Scale (ESS) was used to analyze symptoms.
Results We included 2491 patients with sleep apnea symptoms. OSA frequency (AHI > 15) in each group was 33.2 % in GI; 45.8 in GII and 50.3 in GIII (p < 0.001). Despite the significant increase in OSA severity, GIII group reported fewer symptoms (ESS: 6.0; p < 0.001). Multivariate adjusted analysis showed that the odds ratio of having OSA is three times as high at age > 65 (OR: 3.32 (2.29 - 4.88) p < 0.001).
Conclusions As in previous reports, OSA prevalence in our population was higher among the elderly. The early identification of this syndrome in a population with poor perception of symptoms would aid to improve patient management.
Enhanced On–Off Ratio Photodetectors Based on Lead‐Free Cs3Bi2I9 Single Crystal Thin Films
Authors: Li Wen‐Guang , Wang Xu‐Dong , Liao Jin‐Feng , Jiang Yong , Kuang Dai‐Bin 
Published: February 2020

AbstractHybrid organic–inorganic lead halide perovskite single crystal thin film (SCTF) recently has attracted enormous interest in the field of optoelectronic devices, since it efficiently resolves the trade‐off between thickness and carrier diffusion length. However, the toxicity of lead element and the instability induced by organic component still hinder its future developments. In this work, lead‐free all‐inorganic Cs3Bi2I9 SCTF with a high orientation along (00h) has been in situ grown on indium tin oxide (ITO) glass via a space‐limited solvent evaporation crystallization method. The trap density of Cs3Bi2I9 SCTF (5.7 × 1012 cm−3) is 263 folds lower than that of the polycrystalline thin film (PCTF) counterpart, together with a 5‐order‐of‐magnitude higher carrier mobility. These superior charge transfer properties enable a photoresponse on–off ratio as high as 11 000, which far surpasses that of the PCTF device by 460 folds, comparable to the lead halide perovskite. Furthermore, the Cs3Bi2I9 SCTF photodetector exhibits outstanding stability even without any encapsulation, whose initial performance is well maintained after aging 1000 h in humid air of 50% RH or continuous on–off light illumination for 20 h. This work will pave the way to produce new families of high‐performance, stable, and nontoxic perovskite SCTF for future optoelectronic applications.
Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis
Authors: Wang Shasha , Lv Jing , Meng Shanshan , Tang Jianxin , Nie Liming 
Published: February 2020

AbstractEarly diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.
Exciplex‐Based Organic Light‐Emitting Diodes with Near‐Infrared Emission
Authors: Hu Yun , Yu You‐Jun , Yuan Yi , Jiang Zuo‐Quan , Liao Liang‐Sheng 
Published: February 2020

AbstractNear‐infrared exciplex can weaken molecular design difficulties, and has the advantage of easy bathochromic‐shift spectra via selecting the suitable electron donors and acceptors. In this contribution, exciplex is applied to fabricate near‐infrared (NIR) organic light‐emitting diodes (OLEDs) incorporating a synthesized fluorescent material 3‐([1,1″:3′,1″‐terphenyl]‐5′‐yl)acenaphtho[1,2‐b]pyrazine‐8,9‐dicarbonitrile (APDC‐tPh) and a commercially available material 4,4′,4″‐tris(carbazol‐9‐yl)triphenylamine (TCTA). The device having a mixed TCTA:APDC‐tPh as an emitting layer shows a 730 nm NIR emission with a maximum external quantum efficiency (EQE) of about 0.1%, while the device having 2‐[4‐(diphenylamino)phenyl]‐10,10‐dioxide‐9H‐thioxanthen‐9‐one (TXO‐TPA):APDC‐tPh as the emitting layer exhibits an emission peak of 704 nm with a maximum EQE of 1.27%. These results prove the feasibility of fabricating the efficient exciplex‐based NIR OLEDs.
Countersolvent Electrolytes for Lithium‐Metal Batteries
Authors: Piao Nan , Ji Xiao , Xu Hong , Fan Xiulin , Chen Long , Liu Sufu , Garaga Mounesha N. , Greenbaum Steven G. , Wang Li , Wang Chunsheng , He Xiangming 
Published: February 2020

AbstractDevelopment of electrolytes that simultaneously have high ionic conductivity, wide electrochemical window, and lithium dendrite suppression ability is urgently required for high‐energy lithium‐metal batteries (LMBs). Herein, an electrolyte is designed by adding a countersolvent into LiFSI/DMC (lithium bis(fluorosulfonyl)amide/dimethyl carbonate) electrolytes, forming countersolvent electrolytes, in which the countersolvent is immiscible with the salt but miscible with the carbonate solvents. The solvation structure and unique properties of the countersolvent electrolyte are investigated by combining electroanalytical technology with a Molecular Dynamics simulation. Introducing the countersolvent alters the coordination shell of Li+ cations and enhances the interaction between Li+ cations and FSI− anions, which leads to the formation of a LiF‐rich solid electrolyte interphase, arising from the preferential reduction of FSI− anions. Notably, the countersolvent electrolyte suppresses Li dendrites and enables stable cycling performance of a Li||NCM622 battery at a high cut‐off voltage of 4.6 V at both 25 and 60 °C. This study provides an avenue to understand and design electrolytes for high‐energy LMBs in the future.
Evaluation of sesame genotypes for agronomic traits and stress indices grown under different irrigation treatments
Authors: Gholamhoseini Majid 
Published: February 2020

AbstractSesame (Sesamum indicum L.) is among the oldest cultivated oilseed crops and is regarded as the “queen of oil seeds” because of its oil quality. Since sesame is cultivated in harsh environments, its seed yield is greatly affected by adverse conditions, such as drought. Therefore, we undertook a 2‐yr experiment to understand the effects of deficit irrigation on yield, yield components, oil percentage, water use efficiency, and stress indices of six sesame genotypes. The experiment was conducted at Seed and Plant Improvement Institute, Karaj, located in the semi‐arid region of Iran, during the 2017 and 2018 growing seasons. Deficit irrigation was induced by irrigating after 80% available water depletion, and irrigating after 40% available water depletion was considered to be normal irrigation. Among the genotypes, Oltan and USA‐ns‐96 produced the maximum seed and oil yield. Stress indices analysis revealed that the Sudan‐94 genotype was the most tolerant to deficit irrigation, and the Dashtestan‐2 genotype was the most sensitive. In addition, the Sudan‐94, USA‐ns‐96, and Oltan genotypes showed the highest yield stability index and relative stress index. Regarding drought tolerance, the Sudan‐94 genotype performed the best with minimum reduction in seed yield and other agronomic traits. Overall, these results suggest that the Sudan‐94 genotype is the most drought‐tolerant genotype with the maximum yield stability. Moreover, this study highlights the possibility of using Sudan‐94 genotype in future breeding programs.
Umgang mit Informationssicherheit bei digital unterstützten Bauprojekten
Authors: Wittenborn Arne , Čadež Ivan , Schumann René 
Published: February 2020

AbstractDigitalisierte Prozesse werden in der Bau‐ und Immobilienwirtschaft ein immer bedeutenderer Wirtschaftsfaktor und sind eng mit der Building‐Information‐Modeling‐Methode (BIM‐Methode) verbunden. Obwohl die Anwendung der BIM‐Methode einen Schritt hin zur effizienteren Zusammenarbeit in Bauprojekten darstellt, gehen gleichzeitig auch einige Risiken damit einher. Exemplarisch ist der Diebstahl von sensiblen digitalen Informationen von Bauprojekten Ende des Jahres 2018 in Frankreich zu nennen. Die entwendeten Informationen können auf vielfältige Weise missbraucht werden.Aufgrund fehlender Erfahrung mit der Thematik sind die Beteiligten meistens mit Sicherheitsrisiken, die aus der Digitalisierung von Projektinformationen und der daraus resultierenden Datenmenge hervorgehen, nicht vertraut. Verstärkt wird dieses Problem durch eine noch in der Entwicklung befindliche Normung bzw. Standardisierung.In diesem Beitrag werden zunächst die Ausgangssituation und die Problemstellung in Bezug auf die Informationssicherheit in Bauprojekten dargestellt. Darauf aufbauend werden die wesentlichen Risiken in Bezug auf die Informationen eines Bauprojekts auf Grundlage der digitalisierten Prozesse bei der Anwendung der BIM‐Methode identifiziert.In einem zweiten Beitrag werden beispielhafte Maßnahmen vorgestellt, wie die identifizierten Risiken behandelt bzw. verringert werden könnten.
Photoluminescence emission from nanostructured porous preparations of CdS–ZnTiO3assembled nanoparticles
Authors: Campos‐González E. , Gonzalez de la Cruz G. , Rodriguez‐Fragoso P. , Bravo‐García Y.E. , Castanedo‐Pérez R. , Torres‐Delgado G. , Zelaya‐Angel O. 
Published: February 2020

AbstractThis study reports the structural and optical properties of CdS/ZnTiO3nanocomposites prepared using a chemical bath and different titanate concentrations. Commercial ZnTiO3nanoparticles were introduced into a chemical bath that had been used to produce CdS semiconductor nanoparticles (NPs). Here, the growing CdS crystallites precipitated onto the suspended zinc titanate NPs. X‐ray diffraction patterns revealed that samples of CdS/ZnTiO3nanopowders were made of cubic ZnTiO3and hexagonal CdS wurtzite. The morphology of the particles was studied using transmission electron microscopy and scanning electron microscopy images. These images demonstrated the different characteristics of the CdS/ZnTiO3nanocomposites and their dependence on titanate concentration when placed into the CdS‐growing solution. Photoluminescence spectra showed three main emission bands for the electron transitions in the CdS/ZnTiO3composite. This composite produced three photoluminescence bands, the intensities of which depended on composite shape, which in turn depended on the relative concentrations of CdS and ZnTiO3.
An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody‐Based Therapeutics in Overcoming Chemoresistance
Authors: Kletzmayr Anna , Clement Frey Flurina , Zimmermann Miriam , Eberli Daniel , Millan Christopher 
Published: February 2020

AbstractThe microenvironment plays a major role in conferring chemoresistance to cancer cells. In order to better inform clinical response to chemoresistance, preclinical models that recapitulate its hallmark features are needed to enable screening for resistance‐specific therapeutic targets. A novel platform for seeding cancer cells in 3D hydrogels is presented utilizing derivatives of chitosan and alginate that, critically, is amenable to high throughput screening: cell seeding in hydrogels, media changes, dosing of anticancer compounds, and cell viability assays are all automated using a standard and commercially available liquid handling robot. Culture in these hydrogels elicits resistance in ovarian, lung, and prostate cancer cells to treatment by doxorubicin and paclitaxel. In correlation, proteomics analysis of SKOV3 cells cultured in 3D reveals enrichment of proteins associated with extreme drug resistance including HMOX1 and ALDH2. Subsequently, therapeutic antibodies targeted to tumor‐associated antigens upregulated in 3D cultures are shown to have higher efficacy compared to 2D cultures. Collectively, this automated 3D cell culture platform provides a powerful tool with utility in identification of drugs that may overcome chemoresistance.