bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektifitas Penggunaan ATS (Australasian Triage Scale) Modifikasi Terhadap Response Time Perawat Di Instalasi Gawat Darurat
Authors: Banoet Sofiyanti Normalinda , Harmayetty Harmayetty , Hidayati Laily 
Published: April 2020

Introduction: Triage is the process of sorting patients according to their severity. However, the phenomena that occur in the emergency room of some hospitals are different, triage is not carried out according to the standards. This is due to many factors, one of which is the triage model used. The purpose of this study was to look at the relationship between the use of Standard Operations Procedure for admitting new patients using ATS triage which was modified with the speed of response of nurses in the Emergency Installation. Method: This study used a correlative analytical design with a case study approach. The total population is 31 people and a sample of 28 people was obtained through inclusion and exclusion criteria. The independent variable in this study was the use of ATS (Australasian Triage Scale) and the dependent variable in this study is the nurse's Response Time. Data obtained by means of sample observation and analyzed using the Spearman correlation test rho. Results: There was no association between the use of ATS (Australasian Triage Scale) modification and the response time of nurses in the morning shift (p = 0.720), day shift (p = 0.866) and night shift (p = 0.173).Discussion: From the results of the study there was no relationship between the use of ATS (Australasian Triage Scale) and the response time of nurses in the morning, afternoon and night shift. The use of ATS modification and the response time of nurses that are appropriate and fast are found in morning service. This is caused by several factors both from the nurses themselves and from the hospital. Most nurses do not get training in Triage and this affects nurses' skills in sorting patients.
Necessity of Reviewing and Establishing the National Guidelines Regarding Antimicrobial Therapy for Bacterial Isolates
Authors: Dr. Irfan Ali Mirza  , Dr. Humaira Zafar  , Dr. Wajid Hussain  
Published: April 2020

The emergence of anti-microbial resistance (AMR) is one the biggest challenges faced by the clinicians around the Globe. To coup up with the situation, further management options are heading towards deficiency. In such condition appropriate selection of antibiotics in light of results obtained from culture and sensitivity harbors great significance. The currently used microbiological diagnostic and management options are based upon the guidelines derived from Western data. The National data regarding accurate guidelines for diagnostic and management modalities are deficient. Therefore, the objectives of this review article will be to identify the significance of reviewing and establishing the National guidelines, as a stride to reduce AMR. The literature review had emphasized the need of reviewing and establishing the regional and National guidelines as a significant factor to reduce anti-microbial resistance.
Self Efficacy Dalam Kesiapsiagaan Bencana Gempa Bumi SMP M Boarding School dan SMP M 21 Gantiwarno
Authors: Jayanti Rani Dwi 
Published: April 2020

Abstrak: Penelitian ini mengkaji tentang self efficacy dalam kesiapsiagaan gempa bumi SMP M Boarding School Prambanan dan SMP M 21 Gantiwarno di Kabupaten Klaten. Penelitian ini bertujuan untuk mengetahui self efficacy dalam kesiapsiagaan siswa dalam menghadapi bencana gempa bumi yang mencakup pengetahuan gempa bumi, pengalaman gempa bumi, tindakan siswa terkait gempa bumi, dan persepsi tentang gempa bumi. Sampel yang diambil dalam penelitian ini adalah seluruh siswa SMP M Boarding Prambanan dan SMP M 21 Gantiwarno populasi yakni 235 siswa . Hasil penelitian menyimpulkan 1) pengetahuan gempa bumi Presentase tertinggi 98% untuk indikator keluar ruangan sambil melindungi kepala di SMP M Boarding School Prambanan sedangkan SMP M 21 Gantiwarno 95%. 2) pengalaman gempa bumi Presentase tertinggi 71% untuk indikator pernah mendapatkan pelajaran gempa bumi SMP M Boarding School Prambanan sedangkan SMP M 21 Gantiwarno 31% dengan perbedaan presentase yang signifikan 40%. 3) tindakan siswa terkait gempa presentase tertinggi 98% untuk indikator berlindung dibawah meja yang kokoh SMP M Boarding School Prambanan sedangkan SMP M 21 Gantiwarno 49% . 4) persepsi tentang gempa bumi Presentase tertinggi 98% untuk indikator lebih menyelamatakan diri SMP M Boarding School Prambanan sedangkan SMP M 21 Gantiwarno 94%.
Kata kunci: self efficacy, kesiapsiagaan, gempa bumi

Abstract: This study examines self efficacy with earthquake preparedness at SMP M Boarding School Prambanan and SMP M 21 Gantiwarno in Klaten District. This study aims to determine self-efficacy in students' preparedness in dealing with earthquake disasters that includes earthquake knowledge, earthquake experiences, student actions related to earthquakes, and perceptions about earthquakes. The samples taken in this study were all students of SMP M Boarding School Prambanan and SMP M 21 Gantiwarno population which were 235 students. The results of the study concluded that 1) the highest percentage of earthquake knowledge 98% for the indicator out of the room while protecting the head in SMP M Boarding School Prambanan while 95% in SMP M 21 Gantiwarno.2) earthquake experience The highest percentage of 71% for indicators of having received earthquake lessons was SMP M Boarding School Prambanan while replacing SMP M 21 Gantiwarno 31% with a significant percentage difference of 40%. 3) student actions related to earthquakes highest percentage of 98% for indicators taking shelter under a sturdy table SMP M Boarding School Prambanan while SMP M 21 Gantiwarno 49%. 4) perception of earthquakes Highest percentage 98% for more self-defeating indicators SMP M Boarding School Prambanan while SMP M 21 Gantiwarno 94%.

Keywords: self efficacy, preparadness , earthquake
Pola Spasial Persebaran Penyakit TB Paru Di Kota Malang
Authors: Surjati Endang 
Published: April 2020

Penyakit TB Paru menyebabkan kematian nomor tiga terbesar di Indonesia yang banyak diderita oleh kelompok usia produktif kerja dan golongan ekonomi lemah. Penularan penyakit TB Paru dapat secara langsung ataupun tidak langsung. Tujuan penelitian ini adalah untuk mengetahui pola sebaran prevalensi TB Paru di Kota Malang dan mengetahui faktor-faktor yang berpengaruh terhadap prevalensi TB Paru di Kota Malang. Penelitian ini dengan menggunakan metode nearest neighbor ratio (NNR) untuk mengetahui pola sebaran spasial penyakit TB Paru di Kota Malang. Nilai Nearest Neigborhood Ratio untuk setiap kecamatan di Kota Malang adalah < 1, maka pola sebaran penyakit TB Paru di Kota Malang membentuk pola spasial cluster.
Homoeolog expression bias and expression level dominance (ELD) in four tissues of natural allotetraploid Brassica napus
Authors: Li Mengdi , Wang Ruihua , Wu Xiaoming , Wang Jianbo 
Published: April 2020

Abstract
Background: Allopolyploidy is widespread in angiosperms, and they can coordinate two or more different genomes through genetic and epigenetic modifications to exhibit stronger vigor and adaptability. To explore the changes in homologous gene expression patterns in the natural allotetraploid Brassica napus (AnAnCnCn) relative to its two diploid progenitors, B. rapa (ArAr) and B. oleracea (CoCo), after approximately 7,500 years of domestication, the global gene pair expression patterns in four major tissues (stems, leaves, flowers and siliques) of these three species were analyzed using an RNA sequencing approach. Results: The results showed that the ‘transcriptomic shock’ phenomenon was alleviated in natural B. napus after approximately 7,500 years of natural domestication, and most differentially expressed genes (DEGs) in B. napus were downregulated relative to those in its two diploid progenitors. The KEGG analysis indicated that three pathways related to photosynthesis were enriched in both comparison groups (AnAnCnCn vs ArAr and AnAnCnCn vs CoCo), and these pathways were all downregulated in four tissues of B. napus. In addition, homoeolog expression bias and expression level dominance (ELD) in B. napus were thoroughly studied through analysis of expression levels of 27609 B. rapa-B. oleracea orthologous gene pairs. The overwhelming majority of gene pairs (an average of 86.7%) in B. napus maintained their expression pattern in two diploid progenitors, and approximately 78.1% of the gene pairs showed expression bias with a preference toward the A subgenome. Overall, an average of 48%, 29.7% and 22.3% homologous gene pairs exhibited additive expression, ELD and transgressive expression in B. napus, respectively. The ELD bias varies from tissue to tissue; specifically, more gene pairs in stems and siliques showed ELD-A, whereas the opposite was observed in leaves and flowers. More transgressive upregulation, rather than downregulation, was observed in gene pairs of B. napus. Conclusions: In general, these results may provide a comprehensive understanding of the changes in homologous gene expression patterns in natural B. napus after approximately 7,500 years of evolution and domestication and may enhance our understanding of allopolyploidy.
Nutritional status and associated factors among primary school students, in Meket Wereda, Ethiopia: comparing schools with feeding and non-feeding program
Authors: Demilew Yeshalem Mulugeta , Nigussie Azezu Asres 
Published: April 2020

Abstract
Background: Though undernutrition affects academic performance significant numbers of Ethiopian school children have undernutrition. To avert nutritional problems the government in collaboration with the world food program has implemented a school feeding program. However, data on the nutritional status of primary school students were scarce in the country. Therefore, this study aimed to compare the nutritional status of primary school students enrolled in schools with school feeding programs and in schools without school feeding programs and to identify associated factors in Meket Woreda.Methods: A school-based comparative cross-sectional study was conducted among 1,091 students, from April 1-27/2015. The study participants were selected using a multi-stage stratified sampling method. A structured questionnaire was used to collect data. Data entry and analysis were done using SPSS version 20 software. Descriptive statistics and logistic regression analyses were done. Anthropometric data were analyzed using Anthro-plus software.Results: The prevalence of thinness was 37.5% among students in non school feeding program schools compared with 27.8 % among students in School feeding program schools. Though it wasn’t significant after adjusting for the potential confounders, the prevalence of stunting among students who took meals at school was higher (58.5%) compared with students who did not consume meals at school (48.3%). Students who did not take meal at school [AOR=2.6, 95% CI: (1.8, 3.8)], having uneducated mother [AOR=5.3, 95% CI: (2.2, 12.6)], being a male [AOR=1.9, 95% CI: (1.4, 2.5)], and taking meal once daily [AOR=2.7, 95% CI: (1.6, 3.9)] were positively associated with thinness. Conclusion: The prevalence of thinness was higher among students in schools did not implement school feeding programs compared to their counterparts. Thus, school meal program should be scaling up into schools in food insecure areas.
The Merits of Awake Craniotomy for Glioblastoma in the Left Hemispheric Eloquent Area: One Institution Experience
Authors: Li Ying-Ching , Chiu Hsiao-Yean , Lin Ya-Jui , Chen Ko-Ting , Hsu Peng-Wei , Huang Yin-Cheng , Chen Pin-Yuan , Wei Kuo-Chen 
Published: April 2020

Abstract
Background Awake craniotomy (AC) with intraoperative stimulation mapping is the standard treatment for gliomas, especially those on the eloquent cortex. Many studies have reported survival benefits with the use of AC in patients with glioma, however most of these studies have focused on low-grade glioma. The aim of this study was to evaluate the experience of one treatment center over 10 years for resection of left hemispheric eloquent glioblastoma. Methods This retrospective analysis included 48 patients with left hemispheric eloquent glioblastoma who underwent AC and 61 patients who underwent surgery under general anesthesia (GA) between 2008 and 2018. Perioperative risk factors, extent of resection (EOR), preoperative and postoperative Karnofsky Performance Score (KPS), progression-free survival (PFS) and overall survival (OS) were assessed. Results The postoperative KPS was significantly lower in the GA patients compared to the AC patients (p=0.002). The EOR in the GA group was 90.2% compared to 94.9% in the AC group (p=0.003). The mean PFS was 18.9 months in the GA group and 23.2 months in the AC group (p=0.001). The mean OS was 25.5 months in all patients, 23.4 months in the GA group, and 28.1 months in the AC group (p<0.001). In multivariate analysis, the EOR and preoperative KPSindependently predicted better OS. Conclusion The patients with left hemispheric eloquent glioblastoma in this study had better neurological outcomes, maximal tumor removal, and better PFS and OS after AC than surgery under GA. Awake craniotomy should be performed in these patients if the resources are available.
Bis-benzylidine Piperidone RA190 Treatment of Hepatocellular Carcinoma via Binding RPN13 and Inhibiting NF-κB Signaling
Authors: Soong Ruey-Shyang , Anchoori Ravi K. , Roden Richard B. S. , Cho Rou-Ling , Chen Yi-Chan , Tseng Sheng-Chieh , Huang Yun-Li , Liao Po-Cheng , Shyu Yu-Chiau 
Published: April 2020

Abstract
Background According to GLOBOSCAN, hepatocellular carcinoma (HCC) claimed 782,000 lives in 2018. The tyrosine kinase inhibitor sofafenib is used to treat HCC, but new anticancer agents targeting different pathways are urgently needed to improve outcomes for patients with advanced disease. The aberrant metabolism and aggressive growth of cancer cells can render them particularly susceptible to proteasome inhibition, as demonstrated by bortezomib treatment of multiple myeloma. However, resistance does emerge, and this 20S proteasome inhibitor has not proven active against HCC. The bis-benzylidine piperidone RA190 represents a novel class of proteasome inhibitor that covalently binds to cysteine 88 of RPN13, an ubiquitin receptor subunit of the proteasome’s 19S regulatory particle. RA190 treatment inhibits proteasome function, causing rapid accumulation of polyubiquitinated proteins. Considerable evidence suggests that nuclear factor κB (NF-κB) signaling, which is dependent upon the proteasome, is a major driver of inflammation-associated cancers, including HCC. Methods Human HCC cell lines were treated with titrations of RA190. The time course of endoplasmic reticulum stress and NF-κB-related mechanisms by which RA190 may trigger apoptosis were assessed. The therapeutic activity of RA190 was also determined in an orthotopic HCC xenograft mouse model. Results RA190 is toxic to HCC cells and synergizes with sofafenib. RA190 triggers rapid accumulation of polyubiquitinated proteins, unresolved endoplasmic reticulum stress, and cell death via apoptosis. RA190 blocks proteasomal degradation of IκBα and consequent release of NF-κB into the nuclei of HCC cells. Treatment of mice bearing an orthotopic HCC model with RA190 significantly reduced tumor growth. Conclusions RA190 has therapeutic activity in a xenograft model, and with sorafenib exhibited synergetic killing of HCC cells in vitro, suggesting further exploration of such a combination treatment of HCC is warranted.
Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation
Authors: Blasco Maria Pilar , Chauhan Anjali , Honarpisheh Pedram , Ahnstedt Hilda , d’Aigle John , Ganesan Arunkumar , Ayyaswamy Sriram , Blixt Frank , Venable Susan , Major Angela , Durgan David , Haag Anthony , Kofler Julia , Bryan Robert , McCullough Louise D , Ganesh Bhanu Priya 
Published: April 2020

Abstract
Background Risk of stroke-related morbidity and mortality increases significantly with age. Aging is associated with chronic, low-grade inflammation, which is thought to contribute to the poorer outcomes after stroke seen in the elderly. Histamine (HA) is a major molecular mediator of inflammation and mast cells residing in the gut are a primary source of histamine. Methods Stroke was induced in male C57BL/6J mice at 3 months (young) and 20 months (aged) of age. Role of histamine after stroke was examined using young (Yg) and aged (Ag) mice, mice underwent MCAO surgery and were euthanized at 6h, 24h and 7 days post-ischemia; sham mice received the same surgery but no MCAO. In this work, we evaluated whether worsened outcomes after experimental stroke in aged mice was associated with age-related changes in mast cells, histamine levels, and histamine receptor expression in the gut, brain, and plasma. Results We found increased numbers of mast cells in the gut and the brain with aging. Using the middle cerebral artery occlusion (MCAO) model of ischemic stroke, we demonstrate that stroke leads to increased numbers of mast cells and histamine receptors in the gut. These gut-centric changes are associated with elevated levels of HA and other pro-inflammatory cytokines including IL-6, G-CSF, TNF-α, and IFN-γ in the peripheral circulation. Our data also shows that post-stroke gut inflammation led to a significant reduction of mucin-producing goblet cells and a loss of gut barrier integrity. Lastly, gut inflammation after stroke is associated with changes in the composition of the gut microbiota as early as 24 hours post-stroke. Conclusion An important theme emerging from our results is that acute inflammatory events following ischemic insults in the brain persist longer in the aged mice when compared to younger animals. Taken together, our findings implicate mast cell activation and histamine signaling as a part of peripheral inflammatory response after ischemic stroke, which are profound in aged animals. Interfering with histamine signaling orally might provide translational value to improve stroke outcome.
Serious Infections in People with Systemic sclerosis: A National U.S. Study
Authors: Singh Jasvinder , Cleveland John D. 
Published: April 2020

Abstract
Objective: To study incidence, time-trends and outcomes of serious infections in systemic sclerosis (SSc). Methods: We used the 1998-2016 U.S. National Inpatient Sample data. We examined the epidemiology, time-trends and outcomes of five serious infections (opportunistic infections (OI), skin and soft tissue infections (SSTI), urinary tract infection (UTI), pneumonia, and sepsis/bacteremia) in hospitalized people with SSc. We performed multivariable-adjusted logistic regression analyses to analyze independent association of factors with healthcare utilization (hospital charges, length of hospital stay, discharge to non-home setting), and in-hospital mortality. Results: There were 49,904,955 hospitalizations with serious infections in people without SSc and 61,615 in those with SSc. During 1998-2016, the most common serious infections in SSc were pneumonia (45%), sepsis (32%), SSTI (19%), UTI (3%) and OI (3%). In 2013-14, sepsis surpassed pneumonia as the most common serious infection; by 2015-16, sepsis was 1.8-times more common than pneumonia. Over the study period, hospital charges increased, while length of hospital stay and in-hospital mortality decreased, overall and for each serious infection. Multivariable-adjusted analyses showed that sepsis, age ≥80 years and Deyo-Charlson score ≥2 were associated with significantly higher odds of healthcare utilization and in-hospital mortality; and Medicare or Medicaid insurance payer, Northeast location, urban teaching or non-teaching hospital, and medium or large hospital bed size with significantly higher odds of healthcare utilization. Conclusions: Outcomes in people with SSc hospitalized with serious infections have improved over time, except higher hospital charges. Identification of factors associated with higher healthcare utilization and in-hospital mortality allows for developing interventions to improve outcomes.
The relationship between sleep duration and all-cause mortality in the older people: an updated and dose-response meta-analysis
Authors: He Mengyang , Deng Xiangling , Zhu Yuqing , Huan Luyao , Niu Wenquan 
Published: April 2020

Abstract
Background: Short or long sleep duration is proposed as a potential risk factor for all-cause mortality in the older people, yet the results of published studies are not often reproducible. Objectives: We aimed to investigate whether short or long sleep duration was associated with an increased risk of all-cause mortality in the older people via a comprehensive meta-analysis. Methods: Literature retrieval, study selection and data extraction were completed independently and in duplicate. Effect-size estimates are expressed as relative risk (RR) and its 95% confidence interval (CI). Results: Summary data from 35 articles, involving a total of 106990 older people, were meta-analyzed. Overall analyses revealed a significant association between long sleep duration and all-cause mortality (RR=1.27, 95% CI: 1.19-1.35, P <.001), whereas marginal significance was observed for short sleep duration (RR=1.05; 95% CI: 1.00-1.09; P =.045). There was a low probability of publication bias as indicated by Egger’s test for the association between sleep duration and all-cause mortality. In subgroup analyses, the association between long sleep duration and all-cause mortality was relatively strong in women (RR=1.48, 95% CI: 1.18-1.85, P =.002) relative to men (RR=1.30, 95% CI: 1.10-1.50, P =.001) (Two-sample Z test P = .219). Further dose-response regression analyses showed that trend estimation was not obvious for short sleep duration ( P = .016) compared with long sleep duration ( P < .001), indicating a J-shaped relationship between sleep duration and all-cause mortality. Conclusions: Our findings indicate a J-shaped relationship between sleep duration and all-cause mortality in the older people, with long sleep duration significantly associating with all-cause mortality, especially in women.
Repair of alveolar cleft bone defects by bone collagen particles combined with human umbilical cord mesenchymal stem cells in rabbit
Authors: Sun Xue-Cheng , Wang Hu , Li Jian-Hui , Zhang Dan , Ma Xu , Xia Hong-Fei 
Published: April 2020

Abstract
Background: Alveolar cleft is a kind of cleft lip and palate, which seriously affects the physical and mental health of patients. In this study ， the model of the alveolar cleft phenotype was established in rabbits to evaluate the effect of bone collagen particles combined with human umbilical cord mesenchymal stem cells (HUC-MSCs) on the repair of alveolar cleft bone defects. Methods : The model of alveolar clefts in rabbits was established by removing the incisors on the left side of the upper jaw. Bone collagen particles combined with hUC-MSCs were implanted in the defect area. Blood biochemical analysis was performed after 3 months. Skull tissues were harvested for gross observation, and micro-focus computerized tomography (micro-CT) analysis. Tissues were harvested for histological and immunohistochemical staining. The experiments were repeated 6 months after surgery. Results: The bone collagen particles and HUC-MSCs have good biological safety. In addition, both can promote the regeneration of incisor. Bone collagen particles combined with hUC-MSCs were much better than those used alone in inducing bone repair and regeneration. Conclusions: The method of HUC-MSCs combined with bone collagen particle material to fill a bone defect site is simple, rapid and suitable for the treatment of alveolar cleft bone defects.