bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of staining and repeated firing on the surface and optical properties of lithium disilicate
Authors: Miranda Jean S. , Barcellos Aline S. P. , MartinelliLobo Carolina M. , Caneppele Taciana M. F. , Amaral Marina , Kimpara Estevão T. 
Published: December 2019

AbstractObjectiveEvaluate the effect of staining and repeated firings on color, translucency and surface proprieties of CAD/CAM lithium disilicate (LD).Material and MethodsOne hundred eighty LD discs were made (ISO 6872) and distributed in different groups (n = 20): control (CO)—no treatment; single‐step characterization (SC)—crystallization and staining fired together; and double step characterization (DC)—crystallization and then staining. The samples were submitted to two, four, or six firings, resulting in nine groups: COII, COIV, COVI, SCII, SCIV, SCVI, DCII, DCIV, and DCVI. The color and translucency were measured by a reflectance spectrophotometer. Surface roughness (Ra) and Vickers nano‐hardness were also measured. ANOVA and Tukey statistical tests were used (α = .05).ResultsOnly CO and DC demonstrated significant color alterations (ΔE00 > 1.8). SC and DC did not show changes in translucency by the number of firings (P > .05); however, for CO (P = .02) these values increased. Nano‐hardness was similar in all groups (P > .05). Ra values indicated differences due to the type of characterization (SC presented the highest values) and number of firings (CO and DC groups) (P < .01).ConclusionSC promoted color, translucency, and roughness stability after repeated firings.Clinical SignificanceThe single characterization technic in CAD/CAM lithium disilicate presents good color, translucency, and hardness stability, which promote predictable results to monolithic restoration.
TheCyphomyrusMyers 1960 (Osteoglossiformes: Mormyridae) of the Lufira basin (Upper Lualaba: DR Congo): A generic reassignment and the description of a new species
Authors: Mukweze Mulelenu Christian , Katemo Manda Bauchet , Decru Eva , Chocha Manda Auguste , Vreven Emmanuel 
Published: December 2019

AbstractWithin a comparative morphological framework,Hippopotamyrus aelsbroecki, only known from the holotype originating from Lubumbashi, most probably the Lubumbashi River, a left bank subaffluent of the Luapula River, is reallocated to the genusCyphomyrus. This transfer is motivated by the fact thatH. aelsbroeckipossesses a rounded or vaulted predorsal profile, an insertion of the dorsal fin far anterior to the level of the insertion of the anal fin, and a compact, laterally compressed and deep body. In addition, a new species ofCyphomyrusis described from the Lufira basin,Cyphomyrus lufirae.Cyphomyrus lufiraewas collected in large parts of the Middle Lufira, upstream of the Kyubo Falls and just downstream of these falls in the lower Lufira and its nearby left bank affluent, the Luvilombo River. The new species is distinguished from all its congeners, that is, firstly, fromC. aelsbroecki,C. cubangoensisandC. discorhynchus, by a low number of dorsal fin rays, 27‐32 (vs.higher, 36 (37), 34 (33‐41) an 38 (38‐40), respectively) and, secondly, fromC. aelsbroecki,C. cubangoensis, andC. discorhynchusby a large prepelvic distance, 41.0–43.8%LS(vs.shorter, 39.7%, 38.9–39.1% and 37.0–41.0%LS, respectively). The description of yet another new species for the Upemba National Park and the Kundelungu National Park further highlights their importance for fish protection and conservation in the area. Hence, there is an urgent need for the full integration of fish into the management plans of these parks.
Separation of serum proteins and micellar casein from skim goat milk by pilot‐scale 0.05‐μm pore‐sized ceramic membrane at 50°C
Authors: Yang Baoyu , Zhang Shuwen , Pang Xiaoyang , Lu Jing , Wu Zheng , Yue Yuanchun , Wang Tong , Jiang Zhumao , Lv Jiaping 
Published: December 2019

AbstractThe fractionation of serum protein (SP) and micellar casein (CN) from skim milk can be accomplished using microfiltration (MF). The objective of this study was to determine the removal of total SP using a 0.05‐μm ceramic membrane at each stage of production, as well as the composition of retentates and permeates for a three‐stage, 3×, discontinuous bleed‐and‐feed process. The average flux of ceramic membrane obtained from our results was 96.25 kg/m2 per hour. The cumulative removal rate of actual SP is 96.2% at Stages 1, 2, and 3 (58.1%, 25.0%, and 13.0%, respectively), closely related to the theoretical value of 96%. In addition, the rate of removal of lactose, ash, calcium, and phosphorus were 86.44%, 82.68%, 34.9%, and 55.0%, respectively. The water flux of the membrane reduced by 55.57% after MF, while membrane flux recovered to 99.21% after cleaning with 2% (w/v) sodium hydroxide and 1% (v/v) nitric acid solution. Moreover, permeates and retentates were concentrated by vacuum and spray drier in order to obtain serum and micelle CN powder having protein contents of 10.19% and 75.57%, respectively.Practical applicationsThis article proposes high‐efficiency fractionation of macromolecules and small molecules by membrane technology using skim milk as raw material. Permeate was used to produce high‐quality SP products, which was essentially sterile and fat‐free, and had better solubility, foaming, and gelation than cheese whey protein. And retentates can be directly used for micelle CN powder or cheese production. The composition of the cheese produced was similar to that of traditional cheese. It improves the quality of the products and reduces environmental pollution. In addition, the study also provided a theoretical and applied basis for the membrane separation process of goat milk and the research and development of functional goat milk‐based ingredient.
Instruments for assessing nurses’ palliative care knowledge and skills in specialised care setting: An integrative review
Authors: Soikkeli‐Jalonen Anu , Stolt Minna , Hupli Maija , Lemetti Terhi , Kennedy Catriona , Kydd Angela , Haavisto Elina 
Published: December 2019

AbstractAims and objectivesTo examine the content and reported psychometric properties of instruments for assessing nurses’ palliative care knowledge and skills in specialised healthcare units.BackgroundKnowledge of palliative care, and competence in the delivery of care, is essential. Assessment of competence is an important means of evaluating the knowledge and skills of practitioners in order to improve the quality of care provided for patients and their families.DesignAn integrative review.MethodsA systematic literature search was conducted in November 2018 in five databases: CINAHL, PubMed (Medline), Cochrane, Scopus and Web of Science. The quality assessment was conducted using the Joanna Briggs Institute's (JBI) Checklist for Analytical Cross‐Sectional Studies. The data were analysed using content analysis. PRISMA guidelines were followed to ensure explicit reporting.ResultsOverall, 5,413 studies were identified and 23 met the inclusion criteria. Nurses’ knowledge and skills, as assessed by the instruments, were as follows: (a) care for the patient, (b) care for the patient's family and (c) professional requirements. Ten instruments were identified assessing nurses’ knowledge and skills through knowledge tests and skill evaluation self‐tests. The psychometric properties of the instruments were reported to varying degrees, mainly focusing on internal consistency and content validation.ConclusionsNurses’ knowledge and skills were seen to contribute to the holistic care of the patient and his or her family, and the possession of adequate information and skills is essential when dealing with death and dying. The instruments are commonly available and potentially reliable, although reliability must be determined with caution, so validation studies in other cultures are recommended.Relevance to clinical practiceThese results could be utilised to improve the quality of palliative care by evaluating the knowledge and skills of nursing staff or when considering the needs of palliative care education.
Development and characterization of novel microsatellite markers in Puccinia striiformis f.sp. tritici and their transferability in Puccinia species
Authors: Savadi Siddanna , Prasad Pramod , Bhardwaj Subhash Chander , Rathore Ruchi , Sharma Kiran , Lal Kashyap Prem , Gangwar Om Prakash , Kumar Subodh 
Published: December 2019

AbstractPuccinia striiformis f.sp. tritici (Pst) and P. striiformis f.sp. hordei (Psh) causing stripe rust disease in wheat and barley, respectively, are two devastating phytopathogens. Microsatellite/simple sequence repeat (SSR) markers are increasingly being utilized for analysis of genetic diversity, diagnosis, population structure and possible migratory routes of plant pathogens. In the current study, novel polymorphic SSR markers were designed for Pst using the genomic sequences of PST‐78 isolate. A total of 1,191 SSR motifs, comprising 30% each of di‐ and tri‐nucleotide type of repeats, 17% of penta‐nucleotide, 15% of tetra‐nucleotide and 8% of hexa‐nucleotide repeats, were detected through in silico scanning of PST‐78 genomic sequences. Polymorphism was detected by nine of the 50 designed SSRs (PsSSRs) in seven stripe rust pathotypes of wheat and barley. The mean number of alleles per SSR locus, mean polymorphism information content (PIC), mean heterozygosity, mean major allele frequency (MAF) and mean gene diversity were 2.33, 0.34, 0.33, 0.71 and 0.40, respectively. The dendrogram analysis suggested that newly developed PsSSR markers could distinguish stripe rust pathotypes based on their virulence phenotype. Further, the cross‐genera and cross‐species amplification test of these markers in 14 different rust pathotypes revealed that 9 PsSSRs are capable of amplification in Pst species infecting wild grass, followed by 6 PsSSRs in Pt, 3 PsSSRs in Pgt, 1 PsSSRs in Puccinia species on barberry and Melampsora lini. Thus, the transferability of PsSSRs to other species reduced with increasing genetic distance of target species. These newly designed SSR markers expand the available Pst SSR marker resources and allow better genetic studies.
Growth performance, carcass characteristics, meat quality and serum profile of broiler chicks fed on housefly maggot meal as a replacement of soybean meal
Authors: Elahi Usman , Ma You‐biao , Wu Shu‐geng , Wang Jing , Zhang Hai‐jun , Qi Guang‐hai 
Published: December 2019

SummaryA study was conducted to invesstigate the housefly maggot meal (HMM) as an alternative protein source to replace the soybean meal in broiler chick's diet. A total of 720 1‐day‐old male broiler chicks were divided into three groups and fed diets formulated with HMM to replace soybean meal at the rate of 0%, 4% and 8%. The study lasted for 42 days in two phases. Results showed that HMM addition did not markedly affect body weight, average daily body weight gain and average daily feed intake of the broiler chicks. Feed conversion ratio increased linearly (1–21 days) in starter or quadratically (22–42 days) in the grower phase. HMM non‐significantly increased the feed intake and body weight during the grower phase. Slight changes were observed for decrease of blood biochemical indices in the platelets (day 21), and alkaline phosphatase and lysozyme (day 42), and increase for red blood cells, packed cell volume, total protein and uric acid on day 42; however, the fluctuations were within the physiological range. Non‐significant effects were observed for carcass composition and meat quality, except that HMM numerically reduced the shear force of breast muscle (linear, p = .058). These results are the strong evidence that HMM can be used as an alternative protein source at 8% in broiler chick's diet without any adverse effect on chick's performance.
Between Literature and Psychology: Konishi Masutaro (1862–1940) in the History of Russo–Japanese Scientific Connections
Authors: Maslov Kirill 
Published: December 2019

AbstractThe aim of this paper is to describe some episodes from the life of Konishi Masutaro (1862–1940), a Japanese scholar and psychologist who obtained his theological and psychological education in Russia and who played a role in the development of psychological science in Russia. Masutaro is mostly known as a translator of Lev (Leo) Tolstoy, and the psychological side of his biography is not well studied. Masutaro's life and work in Russia occurred in the context of great political and cultural changes. He was one of the first authors who translated fragments from Eastern philosophy (works by Laozi and Confucius) into the Russian language. Personal and scientific details of the life of this educated scholar are also given in the present paper.
Long non‐coding RNA and mRNA expression profiles in peri‐implantitis vs periodontitis
Authors: Liu Yudong , Liu Qifan , Li Zhipeng , Acharya Aneesha , Chen Danying , Chen Zetao , Mattheos Nikos , Chen Zhuofan , Huang Baoxin 
Published: December 2019

AbstractBackground and ObjectivePeri‐implantitis is a biofilm‐mediated infectious disease that results in progressive loss of implant‐supporting bone. As compared to its analogue periodontitis, peri‐implantitis is generally known to be more aggressive, with comparatively rapid progression and less predictable treatment outcomes, especially when advanced. An understanding of molecular mechanisms underpinning the similarities and differences between peri‐implantitis and periodontitis is essential to develop novel management strategies. This study aimed to compare long non‐coding RNAs (lncRNAs) and messenger RNA (mRNA) expression profiles between peri‐implantitis and periodontitis.MethodsInflamed soft tissue from peri‐implantitis and periodontitis lesions, and healthy gingival tissue controls were analyzed by microarray. Cluster graphs, gene ontology (GO) analysis, and pathway analysis were performed. Quantitative real‐time PCR was employed to verify microarray results. The expression levels of RANKL and OPG in the three tissue types were also evaluated, using qRT‐PCR. Coding non‐coding (CNC) network analyses were performed.ResultsMicroarray analyses revealed 1079 lncRNAs and 1003 mRNAs as differentially expressed in peri‐implantitis when compared to periodontitis. The cyclooxygenase‐2 pathway was the most up‐regulated biological process in peri‐implantitis as compared to periodontitis, whereas hemidesmosome assembly was the most down‐regulated pathway. Osteoclast differentiation was relatively up‐regulated, and RANKL/OPG ratio was higher in peri‐implantitis than in periodontitis.ConclusionsThe study demonstrated that peri‐implantitis and periodontitis exhibit significantly different lncRNA and mRNA expression profiles, suggesting that osteoclast differentiation‐related pathways are comparatively more active in peri‐implantitis. These data highlight potential molecular targets for periodontitis and peri‐implantitis therapy development.
Questioning Bonaventure's Augustinianism?: On the Noetic Effects of Sin
Authors: Sutanto Nathaniel Gray 
Published: December 2019

AbstractRecent scholarship suggests that Bonaventure breaks with the Augustinian tradition, in part, by affirming that the mind's cognitive powers remain fully activated even after the fall. I suggest that this claim concerning Bonaventure's denial of the noetic effects of sin should be reconsidered. I provide evidence to show that Bonaventure did, indeed, affirm that the intellect was heavily damaged by the fall and that Bonaventure affirmed two at first seemingly paradoxical propositions: (1) the intellect is indeed damaged by the fall, and (2) that God remains the first thing known by the intellect. It is precisely Bonaventure's coupling of these two seemingly paradoxical propositions that have led some to underplay Bonaventure's affirmation of the noetic effects of sin. In other words, Bonaventure's model opens up the possibility of affirming that the results of the noetic effects of sin consists not in ignorance of God simpliciter, but in a paradoxical state of knowing-yet-not-knowing God, akin to Paul's account of Romans 1.
Update on pediatric gastroparesis: A review of the published literature and recommendations for future research
Authors: Kovacic Katja , Elfar Walaa , Rosen John M. , Yacob Desale , Raynor Jennifer , Mostamand Shikib , Punati Jaya , Fortunato John E. , Saps Miguel 
Published: December 2019

AbstractBackgroundDue to scarcity of scientific literature on pediatric gastroparesis, there is a need to summarize current evidence and identify areas requiring further research. The aim of this study was to provide an evidence‐based review of the available literature on the prevalence, pathogenesis, clinical presentation, diagnosis, treatment, and outcomes of pediatric gastroparesis.MethodsA search of the literature was performed using the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines with the following databases: PubMed, EMBASE, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, and Web of Science. Two independent reviewers screened abstracts for eligibility.Key ResultsOur search yielded 1085 original publications, 135 of which met inclusion criteria. Most articles were of retrospective study design. Only 12 randomized controlled trials were identified, all of which were in infants. The prevalence of pediatric gastroparesis is unknown. Gastroparesis may be suspected based on clinical symptoms although these are often non‐specific. The 4‐hour nuclear scintigraphy scan remains gold standard for diagnosis despite lack of pediatric normative comparison data. Therapeutic approaches include dietary modifications, prokinetic drugs, and postpyloric enteral tube feeds. For refractory cases, intrapyloric botulinum toxin and surgical interventions such as gastric electrical stimulation may be warranted. Most interventions still lack rigorous supportive data.ConclusionsDiagnosis and treatment of pediatric gastroparesis are challenging due to paucity of published evidence. Larger and more rigorous clinical trials are necessary to improve outcomes.
HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis
Authors: Yang Leiyun , Chen Xiangsong , Wang Zhixue , Sun Qi , Hong Anna , Zhang Aiqin , Zhong Xuehua , Hua Jian 
Published: December 2019

Summary

Plant immune responses need to be tightly controlled for growth–defense balance. The mechanism underlying this tight control is not fully understood. Here we identify epigenetic regulation of nucleotide‐binding leucine rich repeat or Nod‐Like Receptor (NLR) genes as an important mechanism for immune responses.

Through a sensitized genetic screen and molecular studies, we identified and characterized HOS15 and its associated protein HDA9 as negative regulators of immunity and NLR gene expression.

The loss‐of‐function of HOS15 or HDA9 confers enhanced resistance to pathogen infection accompanied with increased expression of one‐third of the 207 NLR genes in Arabidopsis thaliana. HOS15 and HDA9 are physically associated with some of these NLR genes and repress their expression likely through reducing the acetylation of H3K9 at these loci. In addition, these NLR genes are repressed by HOS15 under both pathogenic and nonpathogenic conditions but by HDA9 only under infection condition.

Together, this study uncovers a previously uncharacterized histone deacetylase complex in plant immunity and highlights the importance of epigenetic regulation of NLR genes in modulating growth–defense balance.
Is the taste acuity affected by oral dryness in primary Sjögren’s syndrome patients?
Authors: Al‐Ezzi Minan , Khan Khalid , Tappuni Anwar R. 
Published: December 2019

AbstractObjectivesTaste disturbance is a symptom of primary Sjögren's syndrome (pSS) of unknown aetiology. This study's objectives were (a) to compare taste function in pSS vs. healthy subjects; (b) to establish whether there is an association between the taste acuity and oral dryness and/or the neurosensory threshold; and (c) to assess the impact of taste dysfunction on the quality of life (QoL).MethodologyThis study was conducted on 65 pSS females and 62 healthy volunteers. The gustatory function was tested with taste strips test. Visual analogue scale was used for self‐assessment of taste function. The electrogustometer was used to assess the neurosensory threshold. The oral dryness was assessed by the Clinical Oral Dryness Score, salivary flow rate and Xerostomia Inventory. The general and oral health‐related QoL and mental health well‐being were assessed using validated questionnaires.ResultsThe pSS group had significantly impaired taste function, but this was not correlated with oral dryness. There was an association between taste acuity and the neurosensory threshold (β = −0.5, 95% CI = −0.2 to −0.1). The QoL was not impacted by taste dysfunction (p > .5).ConclusionThe results suggest that taste impairment in pSS is associated with neurosensory dysfunction and is unlikely to be due to oral dryness.
Harnessing the Potential Synergistic Interplay Between Photosensitizer Dark Toxicity and Chemotherapy
Authors: Baglo Yan , Sorrin Aaron J. , Liang Barry J. , Huang Huang‐Chiao 
Published: December 2019

AbstractThe combination of photodynamic therapy and taxol‐ or platinum‐based chemotherapy (photochemotherapy) is an effective and promising cancer treatment. While the mechanisms of action of photochemotherapy are actively studied, relatively little is known about the cytotoxicity and molecular alterations induced by the combination of chemotherapy and photosensitizers without light activation in cancer cells. This study investigates the interplay between the photosensitizer benzoporphyrin derivative (BPD) without light activation and cisplatin or paclitaxel in two glioblastoma lines, U87 and U251. The combination effect of BPD and cisplatin in U87 cells is slightly synergistic (combination index, CI = 0.93), showing 1.8‐ to 2.6‐fold lower half‐maximal inhibitory concentrations (IC50) compared to those of individual drugs. In contrast, combining BPD and paclitaxel is slightly antagonistic (CI = 1.14) in U87 cells. In U251 cells, the combinations of BPD and cisplatin or paclitaxel are both antagonistic (CI = 1.24 and 1.34, respectively). Western blotting was performed to investigate changes in the expression levels of YAP, TAZ, Bcl‐2 and EGFR in U87 and U251 cells treated with BPD, cisplatin and paclitaxel, both as monotherapies and in combination. Our study provides insights into the molecular alterations in two glioma lines caused by each monotherapy and the combinations, in order to inform the design of effective treatments.