bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence Based Model to Predict Labour Productivity for Small &amp; Medium Scale Bus Body Building Society in Present and Post Pandemic Situation
Authors: Nagarajan Bagathsingh , Annamalai Sivakumar , D Arulkirubakaran , P Praveen Vijaya Raj 
Published: August 2020

Abstract
In the recession, the lack of potential labour was the most important concern for the small- and medium-scale bus body fabrication industries. In the pandemic covid-19 situation, the productivity of these fabrication industries was turndown due to deprivation of labour productivity, postponement of work and cost overshoot, which may pilot to argue. In India, Central Tamil Nadu fabrication industries are buttress by immense labour intensity. In this panic situation, these industries are struggling to obtain better productivity. Diversity of earlier works on the detection of the factors with the intention of impacting labour productivity in structural industries and manufacturing sectors has been carried out by research in many countries. Nevertheless, those attempt characteristics are restricted to credentials and implemented in subjective techniques for analysis in declining bus body fabrication sectors. Ambition of this particular research is to recommend an artificial intelligence-based model to predict the “uncertainty factors” influencing labour productivity and safety performance of bus body fabrication industries related to small and medium scale in the pandemic and post pandemic situation.
Food Insecurity and Its Predictors among Lactating Mothers in North Shoa Zone, Central Ethiopia
Authors: Getacher Lemma , Egata Gudina , Aynalem Yared Asmare , Molla Abebaw , Tesfaye Adane , Abebe Haimanot , Alebachew Wubet , Derbie Samuel 
Published: August 2020

Abstract
Background: Ending food insecurity is one of the goals of Sustainable Development Goals (SDGs). It is also one of the serious problems of Ethiopia. However, there is a dearth of studies that show the status of food insecurity among lactating mother in Ethiopia including the study area. Therefore, the objective of this study is to assess the predictors of food insecurity among lactating mothers in Ataye District, North Shoa, and Central Ethiopia. Methods: A community-based cross-sectional study design was used among 612 lactating mothers aged 15-49 years. The food insecurity was determined by computing nine standards Household Food Insecurity Access Scale (HFIAS) questions. A structured interviewer-administered questionnaire was used to collect the data. Data were entered into EpiData version 4.2 and exported to SPSS (Statistical Package for Social Science) version 24 for analysis. Odds ratio with 95% confidence interval was used for the predictors of food insecurity using bivariate and multivariate logistic regression analysis. Results: The prevalence of food insecurity among lactating mothers was 36.8%. No formal education [(AOR=1.82, 95% CL: (1.13, 2.92)], no income-generating activities [(AOR=3.39, 95% CI: ((2.05, 5.64))], no home gardening practices [(AOR=5.65, 95% CI: (3.51, 9.08)], alcohol use by husbands [(AOR=2.02, 95% CI: (1.25, 3.24)], low minimum dietary diversity scores [(AOR=2.94, 95% CI: (1.88, 4.57)], less than three frequencies of meals [(AOR=3.97, 95% CI: (1.65, 9.54)] and three meals only per day [(AOR= 1.86, 95% CI: (1.08, 3.17)] were significant predictors of food insecurity of mothers. Conclusion: The prevalence of food insecurity was high in the study area. No formal education, no income-generating activities, no home gardening practice, alcohol use by husbands, low minimum dietary diversity score, fewer than three frequencies of meals and three meals only per day were independent predictors of food insecurity. Therefore, increasing home gardening, decreasing alcohol intake, increasing dietary diversity, and performing income-generating activities are highly recommended to reduce food insecurity.
Resuscitation Refresher Training in the Wake of the COVID-19 Pandemic – Instructor-led Training Outperforms Self-directed Learning.
Authors: O’Donnell Alice , Pawar Aniela , Hardy Emma , Percival Harriet , Coffin Nicholas , Hulme Jonathan , Owen Andrew , Alderman Joseph 
Published: August 2020

Abstract
Background

survival following out-of-hospital cardiac arrest is worse in the United Kingdom than in many other developed countries, possibly due to below average delivery of early bystander cardiopulmonary resuscitation (CPR). Training laypeople how to perform CPR is vital, but skill decays quickly. Most methods of training require face-to-face contact which is challenging during the Covid-19 pandemic. The optimal method of delivering CPR refresher training is not yet known. Our aim was to understand how basic life support (BLS) performance decays over time, and how best to deliver refresher training in terms of timeframe and training method – are methods with limited instructor / student contact effective?
Methods

this quasi-randomised trial allocated participants to receive refresher training one, two, or three years after their initial BLS training. Participants’ baseline BLS performance was assessed by a trained instructor, and then they were randomly allocated to receive refresher training via one of three methods: one-to-one instructor led training, video assisted learning with self-directed practice, or a written information guide alone. BLS performance was assessed again following refresher training.
Results

42 participants were recruited - all completed all study stages. Baseline BLS performance was poor – only 21% of participants passed a formative assessment. Students who had received BLS training most recently showed better BLS performance than those where greater time had elapsed. one-to-one training was the most effective refresher training modality, and video assisted training did not lead to significant improvement in BLS performance.
Conclusion

one-to-one BLS refresher training outperforms self-directed methods with more limited instructor contact, though it requires greater resource and planning. It may be impractical to deliver instructor-led BLS refresher training during the Covid-19 pandemic. The video we chose to use for our training was not interactive, though such tools exist. Alternative video-led approaches (with or without instructor guidance) should be explored to investigate if they are more effective than the tool we used in this study.
Using 3D Printing Technology for Corrective Biplanar Chevron Osteotomy with Customized Osteotomy Guide and Patient-Matched Monoblock Crosslink Plate in Treatment of Cubitus Varus Deformity: A Case Report and Technical Note
Authors: Sri-utenc Nithid , Pengrung Nachapan , SrikonK Korakod , Puncreobutr Chedtha , Lohwongwatana Boonrat , Sa-ngasoongsong Paphon 
Published: August 2020

Abstract
Background

Cubitus varus deformity (CVD), a common complication after a supracondylar fracture of the distal humerus, is usually treated with corrective osteotomy. However, due to the complex anatomy of the distal humerus, conventional osteotomy techniques are sometimes unreliable and can result in an inaccurate correction, residual deformity, and lateral condyle prominence. Recently, medial three-dimensional (3D) printing technology has demonstrated potential benefits for the treatment of CVD by improving the accuracy of the osteotomy through the use of an osteotomy guide with or without a patient-mated plate. This study aimed to present an interesting CVD case involving a patient who was treated with corrective biplanar Chevron osteotomy using an innovative customized osteotomy guide and a newly designed patient-matched monoblock crosslink plate created with 3D printing technology.
Methods

A computer simulation was processed using images from computerized tomography(CT) scans of both upper extremities. The biplanar Chevron osteotomy was designed to create identical anatomy between the mirror image of the contralateral distal humerus and the osteotomized distal humerus. Next, the customized osteotomy guide and patient-matched monoblock crosslink plate were designed and printed. A simulation osteotomy for the real-sized bone model was created.
Results

The operation was performed using the posterior paratricipital approach and the k-wire position from the customized osteotomy guide as a predrilled hole for screw fixation to achieve immediate control of the reduction after osteotomy. Our method helped successfully treat the CVD in the case study patient and significantly improved her radiographic and clinical outcomes with a satisfactory result.
Conclusion

This study showed that the treatment of CVD using 3D printing technology to create an innovative customized osteotomy guide and a patient-matched monoblock crosslink plate can help accurately assess and control the CVD correction. To the best of our knowledge, this case report introduces a new insight for the clinical application of 3D printing technology in the treatment of CVD.
Number of type 2 diabetes patients achieving HbA1c goal and Related Factors in Brazil: A real world evidence study
Authors: Harder Lillian , Andrade Tarik K , Serra Fernando B , Pinho Felipe M , Pinzon Adolfo , Orengo Juan Carlos 
Published: August 2020

Abstract
Background

Despite the clinical advances in the management of type 2 diabetes mellitus (T2DM) over the past decades, in the US, nearly 48% of patients do not achieve the ADA recommended glycemic goal of glycated hemoglobin (HbA1c) below 7.0%1. The Brazilian Guidelines for the Treatment of T2DM has established the same goal of HbA1c below 7.0%2, but the data for the rate of glycemic goal achievement in Brazil is lacking. The aim of this study was to determine the rate of HbA1c goal achievement among Brazilian patients receiving antidiabetic therapy and investigate its relation to other clinical and demographic covariates.
Methods

Using a cross-sectional database analysis from a group of private clinics in São Paulo, Brazil, this Real Word Evidence study evaluated 1034 patients with T2DM, which were being treated with at least one antidiabetic agent for a minimum of three months and had a basal level of Glycated Hemoglobin (HbA1c) above 7.0%. The number of patients that did not achieve the therapeutic target of HbA1c below 7% was calculated. Demographic and clinical characteristics were collected and a correlation analysis with the treatment target achievement was performed.
Results

The average age of the population was 60.5 years and gender were equally distributed. A total of 60.3% of the patients did not achieve the target of HbA1c below 7% after a minimum of three months treatment with one or more antidiabetic agents. The average time between HbA1c basal to final was 9.9 months. The average basal level of HbA1c was 9.9% ± 2.2 and the final level was 7.8% ± 1.9. In the univariate analysis a statistically significant difference was observed in the following clinical variables: age, total cholesterol level, LDL level, basal and final HbA1c, time to HbA1c final measure, treatment time, and number of antidiabetic agents.
Conclusion

In this retrospective real-world study, only 40% of patients achieved the glycemic target of HbA1c below 7% after at least 3 months of treatment with one or more antidiabetic agent. The average initial HbA1c was 9.9% and the final level was 7.8%. Patients not at goal were older and had more comorbidities, which highlight the challenge that represents the management of diabetes in Brazil. This study confirms previous published data that T2DM glycemic targets are difficult to achieve and the reasons for this are complex and multifactorial
Best Practice Guidelines in Managing the Craniofacial Aspects of Skeletal Dysplasia
Authors: Savarirayan Ravi , Tunkel David E. , Sterni Laura M. , Bober Michael B. , Cho Tae-Joon , Goldberg Michael J , Hoover-Fong Julie , Irving Melita , Kamps Shawn E. , Mackenzie William G. , Raggio Cathleen , Spencer Samantha A. , Bompadre Viviana , White Klane 
Published: August 2020

Abstract
Background
Recognition and appropriate management of the craniofacial manifestations of patients with skeletal dysplasia are challenging, due to the rarity of these conditions, and dearth of literature to support evidence-based clinical decision making.
Methods
Using the Delphi method, an international, multi-disciplinary group of individuals, with significant experience in the care of patients with skeletal dysplasia, convened to develop multi-disciplinary, best practice guidelines in the management of craniofacial aspects of these patients.
Results
After a comprehensive literature review, 23 initial statements were generated and critically discussed, with subsequent development of a list of 22 best practice guidelines after a second round voting.
Conclusions
The guidelines are presented and discussed to provide context and assistance for clinicians in their decision making in this important and challenging component of care for patients with skeletal dysplasia, in order standardize care and improve outcomes.
Characterization of the metasomatizing agent in the upper mantle beneath the northern Pannonian Basin based on Raman imaging, FIB-SEM, and LA-ICP-MS analyses of silicate melt inclusions in spinel peridotite
Authors: Liptai Nóra , Berkesi Márta , Patkó Levente , Bodnar Robert J. , O’Reilly Suzanne Y. , Griffin William L. , Szabó Csaba 
Published: August 2020

AbstractSilicate melt inclusions (SMI) containing several daughter minerals, residual glass, and a CO2 bubble were analyzed to constrain the composition and evolution of the metasomatic melt present in the upper mantle beneath the Nógrád-Gömör Volcanic Field (NGVF), northern Hungary to southern Slovakia. The SMI were analyzed with a combination of Raman spectroscopy, FIB-SEM, and LA-ICP-MS to identify phases and obtain their volume proportions and major- and trace-element geochemistry. Slicing through the entire volume of the inclusions and collecting geochemical information at each slice with FIB-SEM allowed us to model the 3D appearance of the phases within the SMI and to use this information to calculate bulk major-element compositions.The partially crystallized SMI are hosted in clinopyroxene in a lherzolite xenolith that shows evidence of a metasomatic event that altered the lherzolites to produce wehrlites. Based on bulk compositions, the SMI trapped the metasomatic melt linked to wehrlite formation in the NGVF. The melt is enriched in Fe and has an OIB-like trace-element pattern, which suggests an intraplate mafic melt similar to the host basalt, but with slightly different chemistry. Pre-entrapment evolution and reaction with the lherzolite wall rock produced an intermediate melt composition. Petrogenetic modeling indicates that the melt was generated as a result of a very small degree of partial melting of a garnet lherzolite source. Following entrapment, a volatile bubble exsolved from the residual melt during ascent to shallow depths as suggested by consistent densities of CO2 in vapor bubbles. Small crystals, including sulfates and mica, that formed at the boundary of the bubble and the glass indicate that the exsolved fluid originally contained S and H2O, in addition to CO2.
Titanium diffusion profiles and melt inclusion chemistry and morphology in quartz from the Tshirege Member of the Bandelier Tuff
Authors: Boro Joseph R. , Wolff John A. , Neill Owen K. , Steiner Arron R. , Ramos Frank C. 
Published: August 2020

AbstractMany rhyolites contain quartz crystals with relatively Ti-rich rims and Ti-poor cores, with a sharp interface between zones, attributed to partial dissolution followed by overgrowth following a heating event due to mafic recharge of the system. Quartz crystals in the compositionally zoned, high-silica rhyolite Tshirege Member of the Bandelier Tuff erupted at 1.26 Ma from the Valles caldera, New Mexico, show a range in zoning styles with Ti-rich rims becoming more abundant upward in the ignimbrite sheet among progressively less evolved magma compositions. Here we compare times between quartz overgrowth and eruption obtained by applying Ti diffusion coefficients to Ti concentration profiles in Tshirege Member quartz crystals with those from cathodoluminescence (CL) brightness profiles and show that panchromatic CL provides only a crude proxy for Ti in quartz in this unit. Titanium concentrations are measured to detection limits of ~1.2 ppm with small analytical errors (&lt;5%) using MAN backgrounds, blank corrections, and oblique corrected transects to resolve diffusion-relaxed zone boundaries as thin as ~10 μm. Timescales derived from Ti profiles using the widely applied Tiin-quartz diffusion coefficients of Cherniak et al. (2007) range from 60 to 10 000 years, suggesting heating and mobilization events at different times prior to the eruption. However, the use of the newer Ti diffusivities reported by Jollands et al. (2020) yields timescales up to three orders of magnitude longer, including results that are geologically unreasonable for the Bandelier system. We suggest that assumptions commonly made in diffusion modeling, specifically about the form of the Ti zoning profile prior to diffusive relaxation, may be invalid.Melt inclusions in the Ti-poor cores of late-erupted quartz are chemically akin to early erupted melt compositions, while adhering and groundmass glasses more closely reflect the composition of the host pumice. Heating and mobilization events identified from quartz Ti zoning are thus linked to overall compositional zoning of the tuff, which may have been produced by repeated episodes of melting of a crystal cumulate cognate to the early-erupted, evolved rhyolite. Quartz-hosted melt inclusion faceting suggests the development of a crystal mush over a minimum time frame of 1000–10 000 years prior to the recharge events that produced the erupted Tshirege magma at 1.26 Ma.
Effect of cationic substitution on the pressure-induced phase transitions in calcium carbonate
Authors: Martirosyan Naira S. , Efthimiopoulos Ilias , Pennacchioni Lea , Wirth Richard , Jahn Sandro , Koch-Müller Monika 
Published: August 2020

Abstract
The high-pressure CaCO3 phase diagram has been the most extensively studied within the carbonates group. However, both the diverse mineralogy of carbonates and the abundance of solid solutions in natural samples require the investigation of multi-component systems at high pressures (P) and temperatures (T). Here we studied a member of the CaCO3–SrCO3 solid-solution series and revealed the effect of cationic substitution on the pressure-induced phase transitions in calcium carbonate.
A synthetic solid solution Ca0.82Sr0.18CO3 was studied in situ by Raman spectroscopy in a diamond-anvil cell (DAC) up to 55 GPa and 800 K. The results of this work show significant differences in the high-pressure structural and vibrational behavior of the (Ca,Sr)CO3 solid solution compared to that of pure CaCO3. The monoclinic CaCO3-II-type structure (Sr-calcite-II) was observed already at ambient conditions instead of the “expected” rhombohedral calcite. The stress-induced phase transition to a new high-pressure modification, termed here as Sr-calcite-IIIc, was detected at 7 GPa. Sr-calcite-VII formed already at 16 GPa and room T, which is 14 GPa lower compared to CaCO3-VII. Finally, crystallization of Sr-aragonite was detected at 540 K and 9 GPa, at 200 K lower T than pure aragonite. Our results indicate that substitution of Ca2+ by bigger cations, such as Sr2+, in CaCO3 structures can stabilize phases with larger cation coordination sites (e.g., aragonite, CaCO3-VII, and post-aragonite) at lower P-T conditions compared to pure CaCO3. The present study shows that the role of cationic composition in the phase behavior of carbonates at high pressures should be carefully considered when modeling the deep carbon cycle and mantle processes involving carbonates, such as metasomatism, deep mantle melting, and diamond formation.
Drug Repositioning for the Treatment of Hematologic Disease: Limits, Challenges and Future Perspectives
Authors: Allegra Alessandro , Imbesi Chiara , Bitto Alessandra , Ettari Roberta 
Published: August 2020

:
Drug repositioning is a strategy to identify new uses for approved or investigational
drugs that are used off-label outside the scope of the original medical indication.

:
In this review, we report the most relevant studies about drug repositioning in hematology,
reporting the signalling pathways and molecular targets of these drugs, and describing the biological
mechanisms which are responsible for their anticancer effects.

:
Although the majority of studies on drug repositioning in hematology concern acute myeloid
leukemia and multiple myeloma, numerous studies are present in the literature on the possibility
of using these drugs also in other hematological diseases, such as acute lymphoblastic leukemia,
chronic myeloid leukemia, and lymphomas. Numerous anti-infectious drugs and
chemical entities used for the therapy of neurological or endocrine diseases, oral antidiabetics,
statins and medications used to treat high blood pressure and heart failure, bisphosphonate
and natural substance such as artemisin and curcumin, have found a place in the treatment of
hematological diseases. Moreover, several molecules drastically reversed the resistance of the
tumor cells to the chemotherapeutic drugs both in vitro and in vivo.
The Potential of Milk-Derived Exosomes for Drug Delivery
Authors: Li Shuyuan , Tang Yue , Dou Yushun 
Published: August 2020

Background:
Exosomes, one of the extracellular vesicles, are widely present in all biological
fluids and play an important role in intercellular communication. Due to their hydrophobic lipid bilayer
and aqueous hydrophilic core structure, they are considered a possible alternative to liposome drug delivery
systems. Not only do they protect the cargo like liposomes during delivery, but they are also less
toxic and better tolerated. However, due to the lack of sources and methods for obtaining enough
exosomes, the therapeutic application of exosomes as drug carriers is limited.

Methods:
A literature search was performed using the ScienceDirect and PubMed electronic databases
to obtain information from published literature on milk exosomes related to drug delivery.

Results:
Here, we briefly reviewed the current knowledge of exosomes, expounded the advantages of
milk-derived exosomes over other delivery vectors, including higher yield, the oral delivery characteristic
and additional therapeutic benefits. The purification and drug loading methods of milk exosomes, and
the current application of milk exosomes were also introduced.

Conclusion:
The emergence of milk-derived exosomes is expected to break through the limitations of
exosomes as therapeutic carriers of drugs. We hope to raise awareness of the therapeutic potential of
milk-derived exosomes as a new drug delivery system.