bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological and clinical factors associated with post-exertional malaise severity in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Ghali Alaa , Richa Paul , Lacout Carole , Gury Aline , Beucher Anne-Berengere , Homedan Chadi , Lavigne Christian , Urbanski Geoffrey 
Published: June 2020

Abstract
Background
Post-exertional malaise (PEM), the cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), occurs generally after exposure to a stressor. It is characterized by the worsening of ME/CFS symptoms and results in aggravating the course of the disease and the quality of life of patients. Due to its unpredictable onset, severity, and recovery time, identifying patients with higher risk for severe PEM would allow preventing or reducing its occurrence. We thus aimed at defining possible factors that could be associated with PEM severity.

Methods
Adult patients fulfilling ME international consensus criteria who attended the internal medicine department of University hospital Angers-France between October 2011 and December 2019 were included retrospectively. All patients were systematically hospitalized for an etiological workup and overall assessment. We reviewed their medical records for data related to the assessment: epidemiological data, fatigue features, clinical manifestations, and ME/CFS precipitants. PEM severity was appreciated by the Center for Disease Control self-reported questionnaire. The study population was classified into quartiles according to PEM severity scores. Analyses were performed with ordinal logistic regression to compare quartile groups.

Results
197 patients were included. PEM severity was found to be positively associated with age at disease onset ≥ 32 years (OR 1.8 [95% CI 1.1–3.0] (p = 0.03)), recurrent infections during the course of the disease (OR 2.1 [95% CI 1.2–3.7] (p = 0.009)), and when ME/CFS was elicited by a gastrointestinal infectious precipitant (OR 5.7 [1.7–19.3] (p = 0.006)).

Conclusion
We identified some epidemiological and clinical features, which were positively associated with PEM severity in subsets of ME/CFS patients. This could help improving disease management and patients’ quality of life.
COVID-19 pandemia and inherited cardiomyopathies and channelopathies: a short term and long term perspective
Authors: Limongelli Giuseppe , Crotti Lia 
Published: June 2020

AbstractInherited heart disease represent a very heterogenous group of cardiac disorders, characterized by inherited, acquired, and often rare disorders affecting the heart muscle (cardiomyopathies) or the cardiac electrical system (ion channel disease). They are often familial diseases, and are among the leading cause of juvenile sudden death and heart failure. The aim of this paper is to give a perspective on how to run a clinical service during an epidemic or pandemic emergency and to describe the potential COVID-19 associated risks for patients affected by inherited heart diseases.
Furosemide use in Italian neonatal intensive care units: a national survey
Authors: Manfredini Valeria Anna , Cerini Chiara , Clavenna Antonio , Dotta Andrea , Caccamo Maria Letizia , Staffler Alex , Massenzi Luca , Rezzonico Rossano Massimo ,   on the behalf of study Group of Neonatal Pharmacoterapy of the Italian Society of Neonatology
Published: June 2020

AbstractBackgroundFurosemide is approved in full term neonates to treat edema associated with congestive heart failure, cirrhosis and renal diseases. It is often administered off-label in premature neonates, to treat respiratory conditions and at doses greater-than-recommended. We conducted a national survey on behalf of the Neonatal Pharmacotherapy Study Group of the Italian Society of Neonatology (SIN), to investigate its use in Italian neonatal intensive care units (NICUs), in conformity with current guidelines.MethodsBetween December 2016 and June 2017, a 14-item multiple-choice online questionnaire was sent to all NICU directors from the SIN directory.Gestational age, route of administration, posology, indications, referenced guidelines, adverse effects monitoring and the presence of Paediatric Cardiology or Cardiosurgery service on site were assessed. A chi-square test was performed 1) to evaluate differences in the distribution of responses between NICUs administering furosemide at doses higher-than-recommended; 2) to compare the proportion of NICUs administering furosemide at high doses in institutions with versus without a Paediatric Cardiology or Cardiosurgery service.ResultsThe response rate was 50% (57/114). The intravenous and oral routes were chosen primarily; the intravenous administration in single doses predominated over continuous infusion. Its main therapeutic indications were congestive heart failure/overload (94.7%) and oligo-anuria (87.7%) however furosemide was also frequently used for broncopulmonary dysplasia (50.9%) and respiratory distress syndrome and/or transient tachypnea of the newborn (24.6%).In 28/57 NICUs furosemide was administered at doses higher-than-recommended. In most NICUs the same posology was used in term and preterm neonates. Compared to the total sample, a larger proportion of NICUs administering doses greater-than-recommended referenced current literature for reasons to do so (19.3 and 32.1% respectively). The presence of a Paediatric Cardiology or Cardiosurgery service on site did not correlate with the chosen posology.The majority of NICUs performed acoustic test and renal ultrasound for furosemide exposure greater than 2 weeks.ConclusionsIn Italian NICUs, furosemide is commonly prescribed to term and preterm newborns for label and unlabeled indications. Doses greater-than-recommended are frequently administered. Such use is not necessarily inappropriate. More research is required to assess the efficacy and safety of unlabeled use.
Predictors of cartilage degeneration in patients with subchondral insufficiency fracture of the femoral head: a retrospective study
Authors: Shimizu Tomohiro , Yokota Shunichi , Kimura Yosuke , Asano Tsuyoshi , Shimizu Hirokazu , Ishizu Hotaka , Iwasaki Norimasa , Takahashi Daisuke 
Published: June 2020

AbstractBackgroundThere is evidence that the cause of primary osteoarthritis (OA) is related to the changes in subchondral bone; however, the influence of subchondral insufficiency fracture (SIF) of the femoral head on the degeneration of the hip joint and the prognostic factors related to joint degeneration remain unclear. The objectives of this study were (1) to investigate the natural history of joint space width after the occurrence of SIF and (2) to investigate the associations between joint space narrowing and bone metabolic markers as well as magnetic resonance imaging (MRI) among the patients with SIF.MethodsBetween January 2010 and December 2019, 238 patients in whom band pattern of the femoral head were observed on MRI visited Hokkaido University Hospital. Among these patients, 44 hips in 41 patients were diagnosed with SIF and eligible for this retrospective study. We evaluated the joint space width (JSW) of the hip on the radiograph obtained at the first and last visits, length of the band lesion on MRI, bone mineral density by dual-energy X-ray absorptiometry, and bone metabolism markers. Similarly, the factors associated with the necessity of surgery and the progression of the narrowing of the joint space were evaluated.ResultsFifteen of the 44 hips required total hip arthroplasty (THA). A significant decrease was observed in the JSW from the first visit to the final follow-up. Changes in the JSW were associated with the length of band patterns, serum type 1 procollagen-N-propeptide (P1NP), and tartrate-resistant acid phosphatase 5b (TRACP-5b) during diagnosis. Additionally, bone metabolic markers tended to be associated with the length of the band pattern.ConclusionsSIF could cause joint space narrowing and hip OA. In addition to MRI findings as prognostic predictors of SIF, as previously described, bone metabolic markers were equally associated with changes in JSW, suggesting that these parameters could be useful in predicting the prognosis of SIF. Considering that bone metabolic markers trended to be associated with the length of band pattern, they might reflect the local severity.
Parenchymal lung disease in adult onset Still’s disease: an emergent marker of disease severity—characterisation and predictive factors from Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort of patients
Authors: Ruscitti Piero , Berardicurti Onorina , Iacono Daniela , Pantano Ilenia , Liakouli Vasiliki , Caso Francesco , Emmi Giacomo , Grembiale Rosa Daniela , Cantatore Francesco Paolo , Atzeni Fabiola , Perosa Federico , Scarpa Raffaele , Guggino Giuliana , Ciccia Francesco , Barile Antonio , Cipriani Paola , Giacomelli Roberto 
Published: June 2020

Abstract
Background
Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder of unknown aetiology usually affecting young adults. Interestingly, recent evidence from the juvenile counterpart of AOSD suggested the emergent high fatality rate of lung disease (LD) in these patients. In this work, we aimed to characterise LD in AOSD, to identify associated clinical features and predictive factors, and to describe long-term outcomes of the disease comparing patients with LD and those without.

Methods
A retrospective assessment of prospectively followed patients, from January 2001 to December 2019, was provided to describe the rate of LD in AOSD, associated clinical features and predictive factors, and long-term outcomes. Patients with AOSD, who were included in Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort, were assessed.

Results
Out of 147 patients included in GIRRCS cohort, 18 (12.25%) patients were reported to be affected by LD, at the time of diagnosis of AOSD, who were characterised by older age, a higher prevalence of myalgia, of lymph node involvement, of pleuritis, and abdominal pain. Furthermore, patients with LD showed higher values of systemic score and ferritin. Among those clinical variables, older age and systemic score were also independently predictors of LD. Chest CT scans were also obtained, and the most common finding was the peripheral consolidations in 8 (44.4%) patients. Finally, a higher mortality rate, of 38.9%, was registered in patients with LD than others, since it was associated with a significant decreased survival rate.

Conclusions
The presence of LD could suggest an emergent cause of mortality in AOSD, as observed in juvenile counterpart recognising a further marker of severity and poor prognosis to be careful evaluated. Patients with LD were also characterised by some clinical features, higher values of systemic score and ferritin than the others, identifying a subset of patients mostly burdened by systemic signs and symptoms. Although specific designed future studies are needed to fully elucidate the significance of LD in AOSD, a more accurate evaluation and management of this feature could improve the long-term outcomes of these patients.
Stool cultures show a lack of impact in the management of acute gastroenteritis for hospitalized patients in the Bronx, New York
Authors: Fraij Omar , Castro Neva , de Leon Castro Luis A. , Brandt Lawrence J. 
Published: June 2020

Abstract
Background
Acute gastroenteritis (AGE) is diagnosed with a presentation of > 1
episode of vomiting and > 3 episodes of diarrhea in a 24-h period. Treatment is
supportive, however, in severe cases antibacterial treatment may be indicated. Stool
cultures can detect the responsible pathogenic bacteria and can guide antibiotic
treatment, however, the indication for and efficacy of stool cultures is debatable. This
study aimed to address the clinical utility of stool cultures in patients diagnosed with
AGE.

Methods
A retrospective, multicenter study was performed in patients admitted for
AGE from 2012 to 2014. Patient charts were obtained through hospital software using
ICD-9 codes for AGE. Inclusion criteria was a documented diagnosis of AGE, age of 18
years or older, symptoms of both upper GI symptoms of abdominal pain and/or nausea
and lower GI symptoms of diarrhea. Patients were classified into two main groups,
those in whom (1) stool culture was obtained and (2) those in whom stool culture was
not performed. Clinical features and outcomes were compared between groups. The
diagnostic yield of stool cultures was assessed. All analysis were conducted using the
Statistical Package for Social Science (SPSS).

Results
Of 2479 patient charts reviewed, 342 met the above criteria for AGE. 119
patients (34.8%) had stool cultures collected and 223 (65.2%) did not. Demographics,
clinical features and serologic lab values are shown in Table 1. Of the 119 stool
cultures performed, only 4% (n = 5) yielded growth of pathogenic bacteria (2
Pseudomonas spp, 2 Campylobacter spp, 1 Salmonella spp). The group who
underwent stool culture had a higher percentage of patients with fevers (26% vs 13%,p < 0.003) and longer hospital length of stay (3.15 vs 2.28 days, p < 0.001) compared
to the group that did not undergo stool cultures.

Conclusion
Stool cultures are commonly ordered when AGE is suspected. In our
cohort, stool culture had a very low yield of detecting an underlying pathogen. Although
patients who had stool cultures obtained were more likely to be febrile and to have a
longer length of hospital stay than were those who did not have stool cultures, for the
vast majority of patients, stool culture played little to no role in patient management.
Further studies are needed to which patients benefit most from undergoing stool
culture.
Investigation of Burkholderia cepacia complex bacteremia outbreak in a neonatal intensive care unit: a case series
Authors: Bharara Tanisha , Chakravarti Anita , Sharma Mukesh , Agarwal Priti 
Published: June 2020

Abstract
Introduction
Burkholderia cepacia complex is a ubiquitous organism with a high virulence potential. It is found most commonly in moist environments. Hospital outbreaks have been reported from diverse sources such as contaminated faucets, nebulizers, disinfectant solutions, multidose antibiotic vials, tap water, bottled water, nasal sprays, and ultrasound gels. In this article, we present our experience in investigating and successfully managing an outbreak of nosocomial transmission of Burkholderia cepacia sepsis in the neonatal intensive care unit at SGT Hospital, Haryana, India.

Case presentation
During the month of March, multiple Burkholderia cepacia complex isolates were recovered from blood cultures of Caucasian babies admitted to the neonatal intensive care unit of our hospital. The organisms were multidrug-resistant, with in vitro sensitivity to meropenem alone (minimum inhibitory concentration = 4 μg/ml). An outbreak was suspected, and the neonatal intensive care unit in-charge and hospital infection control teams were alerted. Outbreak investigation was initiated, and surveillance samples were collected. Burkholderia cepacia complex was successfully isolated from suction apparatus. The isolates were phenotypically typed (biotyping and antimicrobial susceptibility testing) and found to be identical.

Conclusions
In our study, the index case might have been exposed to infection due to a physiological state of low immunity (preterm, low birth weight, and mechanical ventilation). The rest of the cases might have been exposed to this organism due to inadequate hand hygiene/improper cleaning and disinfection practices. Timely reporting and implementation of infection control measures played a significant role in curtailing this outbreak.
Research on semi-supervised multi-graph classification algorithm based on MR-MGSSL for sensor network
Authors: Gang Yang , Na Zhang , Tao Jin , Dawei Wang , Yinzhu Kang , Feng Gao 
Published: June 2020

AbstractWith the advent of the era of network information, the amount of data in network information is getting larger and larger, and the classification of data becomes particularly important. Current semi-supervised multi-map classification methods cannot quickly and accurately perform automatic classification and calculation of information. Therefore, this paper proposes an MR-MGSSL algorithm and applies it to the classification of semi-supervised multi-graph. By determining the basic idea and calculation framework of MR-MGSSL algorithm, the mining of optimal feature subsets in multi-graphs and the multi-graph vectorization performance time are taken as examples, and the proposed algorithm is compared with other semi-supervised multi-graph classification methods. The performance evaluation results show that compared with other classification calculation methods, MR-MGSSL algorithm has the advantages of low sensitivity to feature subgraph and short vectorization time. The method is used to extract and detect clouds in remote sensing images (GF-1 and GF-2).
Critical Reliability Issues of Common Type Alcohol-Based Handrub Dispensers
Authors: Bánsághi Száva , Soule Hervé , Guitart Chloé , Pittet Didier , Haidegger Tamás 
Published: June 2020

Abstract
Background
Hand hygiene can only be efficient if the whole hand surface is treated with sufficient alcohol-based handrub (ABHR); therefore, the volume of handrub applied is a critical factor in patient safety. The proper amount of ABHR should be provided by handrub dispensers. The aim of this study was to investigate the dispensing performance of wall-mounted ABHR dispensers commonly employed in hospital settings.

Method
In a multicenter study, we tested 46 dispensers (22 in laboratory and 24 in clinical environments), measuring dispensed ABHR volume during continuous use and after a period of non-use. The influence of the pumping mechanism, liquid level, ABHR formats, handrub composition, temperature, and atmospheric pressure was investigated.

Results
A total of 7 out of the 22 investigated dispensers (32%) lost a significant amount of handrub; greater than 30% of the nominal volume after 8 h of non-use, thus frequently dispensing suboptimal volume, as measured in laboratory settings. Key influencing factors were found to be handrub format (gel or liquid), handrub level in the container and type of dispenser. When gel ABHR was used, after 4 h of non-use of the dispensers, the volume of the dispensed amount of ABHR insignificantly changed (97% of the original amount), while it technically decreased to zero in the case of liquid ABHR (1% of the original amount). The liquid level had a medium effect on the dispensed volume in each investigated case; the magnitude of this effect varied widely depending on the dispensing mechanism. When dispensers were in continuous use, they dispensed a cumulated 3 mL of ABHR from two consecutive pushes, while when they were not in use for 1 h, up to 4 consecutive pushes were necessary to provide a total of 3 mL ABHR. Design and production quality were also identified as important contributing factors with respect to the volume dispensed. Data collected in clinical settings confirmed these findings, for multiple types of dispensers.

Conclusion
All ABHR dispensers should be regularly audited to control the reference volume distributed, with particular attention paid to regular mechanical pump units filled with liquid handrub.
RNA sequencing reveals that Prx II gene knockout can down-regulate the allograft rejection of dermal mesenchymal stem cells
Authors: Han Ying-Hao , Mao Ying-Ying , Yu Nan-Nan , Jin Mei-Hua , Jin Ying-Hua , Wang Ai-Guo , Zhang Yong-Qing , Shen Gui-Nan , Cui Yu-Dong , Yu Li-Yun , Lee Dong-Seok , Jo Yu-Jin , Sun Hu-Nan , Kwon Jeongwoo , Kwon Taeho 
Published: June 2020

AbstractIn this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) andPrx IIknockout DMSCs (n = 3). The purpose of the study was to elucidate the role ofPrx IIon allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated;p ≤ 0.05) between the PrxII+/+(WT) and PrxII−/−sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/−samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/−vs. PrxII+/+(WT) samples. These findings suggest thatPrx IIgene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
The relationship between age and suicidal thoughts and attempted suicide among prisoners
Authors: Stoliker Bryce E. , Verdun-Jones Simon N. , Vaughan Adam D. 
Published: June 2020

Abstract
Background
Suicide is a major problem across the lifespan, yet rates are highest among middle-aged and older adults; a trend which remains relatively stable across varying sociological settings, including prisons. Despite this understanding, there is limited knowledge on the nature of suicidal thoughts and attempts among older prisoners, especially with respect to how they compare to younger counterparts. The present study aimed to increase insight into the relationship between age and suicidal thoughts and attempted suicide among prisoners, with particular focus on factors that may explain age-based variability.

Results
Cross-sectional data were drawn from a nationally representative sample of 18,185 prisoners housed within 326 prisons across the United States. In general, analyses revealed that: (a) attempted suicide was more commonly reported among younger prisoners, while suicidal ideation was more commonly reported among older prisoners; (b) the relationship between age and probability of reporting suicidal thoughts and behavior is curvilinear; (c) younger and older prisoners exhibit somewhat differing predictive patterns of suicidal thoughts and behavior (e.g., physical illness is directly associated with suicidal history for younger prisoners, whereas the effect of physical illness on suicidal history for older prisoners is mediated by depression).

Conclusions
There is evidence to suggest that suicidal thoughts and behavior may manifest differently for younger and older prisoners, with differing patterns of risk. More research is needed on age-based variability in suicidal thoughts and attempted suicide among prisoners, as well as those factors that might explain this variability. Importantly, future research must continue to investigate the nature of suicidal thoughts and behavior among older prisoners.