bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Neurobehavioral and Biochemical Parameters of Poly- Herbal Formulation on MPTP-Intoxicated Mice for the Treatment of PD
Authors: Srivastava Amit K. , Naseer Arif , Gupta Amresh 
Published: October 2019

Background:
Formulations containing two or more than two herbs are called polyherbal
formulation. Single herb formulation has been well established due to its active phytoconstituents,
which are usually present in minute amount and sometimes these are insufficient to achieve the desired
therapeutic effects. The popularity of polyherbal formulation is due to its high effectiveness in a vast
number of diseases.

Methods:
In this study, poly-herbal formulations were prepared by using different solvent extracts with
the help of the hot extraction process through Soxhlet apparatus. The poly-herbal formulations were
prepared by using traditional herbal plants namely, Bacopa monereri (BM), Embelica officinalis (EO),
Mucuna pruriens (MP), & Withania somnifera (WS). Different combinations of PHFs (PHF1-5) were
prepared by using the extracts in different ratios. The prepared PHFs were optimized for antioxidant
potential by the DPPH assay. Eighteen Swiss albino mice (30-50 g) were grouped into Control,
MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPTP+PHF1 (6 mice in each group). Experimental
mice were given PHF1 (50 mg/kg body weight by intraperitoneal route). MPTP(1-methyl 4-
phenyl 1,2,3,6-tetrahydropyridine) treatment was given orally for 2 weeks with prior use of 20 mg/kg
body weight for 2 weeks.

Discussion:
In the above study, it was found that PHF1 has upgraded the dopaminic neurons in the
brain. A significant diminution was found in SLA activity in MPTP treated mice as compared to the
control group which was restored by MPTP+PHF1 treated group as compared to MPTP treated group.

Results:
After the treatment period, neurobehavioral study and evaluation of neuroprotective effects
were done according to biochemical parameters.

Conclusions:
The result concluded that PHF1 enhanced the dopaminic neurons in the substantia nigra
region of the brain. Hence, this poly-herbal formulation gives a better and novel treatment base for future
drug discoveries in the case of Parkinson’s Disease (PD).
The Preventive Effect of IL-1beta Antagonist on Diabetic Peripheral Neuropathy
Authors: Hangping Zheng , Ling Han , Lijin Ji , Wenting Zhao , Xiaoxia Liu , Qi Zhang , Xiaoming Zhu , Qingchun Li , Yiming Li , Qian Xiong , Ji Hu , Bin Lu , Shuo Zhang 
Published: October 2019

Objective:
To investigate the relationship between Interleukin-1beta (IL-1beta) and diabetic
peripheral neuropathy (DPN) using animal models.

Materials:
The rat model of diabetic neuropathy was induced by intraperitoneal injection of a single
dose of streptozotocin (STZ) at 65mg/kg. Diabetic rats were randomly divided into two groups (10
each), one treated with 0.9% saline (DMS group) and the other with interleukin-1 receptor antagonist
(IL-1RA) at 50mg/kg (DMI group) twice a day for 5 weeks. Ten normal rats matched for weight, age
and sex served as normal controls (Con group) and were treated with saline. Morphologic studies of
sciatic nerves were achieved using light and transmission electron microscopy.

Results:
Transmission electron microscopy of the sciatic nerve showed the ultrastructure of myelin and
the axon in the IL-1RA group was highly protected compared to diabetic controls.

Conclusions:
High levels of circulating IL-1beta may be associated with the risk of DPN and anti-IL-1
treatment may provide a potential strategy for the prevention of diabetic neuropathy.
Gastrointestinal Region Specific Insulin Permeation Enhancement by Aloe vera Gel
Authors: Pretorius Elizca , Willers Clarissa , Hamman Josias H. , Steyn Johan D. 
Published: October 2019

Background:
The oral administration route is still the most preferred by patients for drug
treatment, but is unfortunately not suitable for all drug compounds. For example, protein and peptide
drugs (e.g. insulin) are typically administered via injection seeing as they are unstable in the gastrointestinal
luminal environment and have poor membrane permeation properties. To overcome this problem,
functional excipients such as drug absorption enhancers can be co-administered. Although Aloe vera gel
has the ability to improve the permeation of drugs across the intestinal epithelium, its drug permeation
enhancing effect has not been investigated in the different regions of the gastrointestinal tract yet.

Objective:
The aim of this study was to investigate the insulin permeation enhancing effects of A. vera
gel material across excised pig intestinal tissues from different regions of the gastrointestinal tract and
to identify the gastrointestinal region where the highest insulin permeation enhancement was achieved.

:
Insulin transport across excised pig intestinal tissues from the duodenum, proximal jejunum,
medial jejunum, distal jejunum, ileum and colon was measured in the absence and presence of A. vera
gel (0.5% w/v) using both the Sweetana-Grass diffusion chamber and everted sac techniques.

Results:
The insulin permeation results obtained from both ex vivo techniques showed varied permeation
enhancing effects of A. vera gel as a function of the different regions of the gastrointestinal tract.
The colon was identified as the gastrointestinal region where A. vera gel was the most effective in terms
of insulin permeation enhancement in the Sweetana-Grass diffusion chamber technique with a Papp
value of 5.50 x 10-7 cm.s-1, whereas the ileum was the region where the highest permeation enhancement
occurred in the everted sac technique with a Papp value of 5.45 x 10-7 cm.s-1.

Conclusion:
The gastrointestinal permeation enhancing effects of A. vera gel on insulin is region specific
with the highest effect observed in the ileum and colon.
SYMBOLIC FUNCTIONS OF FOOD IN SELECTED INDONESIAN CHILDREN’S WRITINGS KKPK SERIES
Authors: Wulandari Retno , Desiningrum Dinie Ratri 
Published: October 2019

Abstract Food is one of the elements that can reveal the society’s dynamic, beliefs, ideology, and values. The relation of food and literature is inevitable as food is part of culture, then the relations of characters in a work of literature may involve food. This paper is intended to investigate the symbolic functions of food in some Indonesian children’s writings Kecil-Kecil Punya Karya (KKPK) series, namely Izzati’s Let’s Bake Cookies, Alifia’s Egg Ice Cream, and Haura’s Resep Baru (New Recipe). The umbrella of the theory is Roland Barthes’ food as signifying system and it is applied in the context of children’s literature. In addition, to scrutinize the cultural-social and production of the work, Bourdieu’s field of cultural production theory is applied. Close-reading is used to collect data in the three writings. The data are tabulated and then analyzed through sociological approach and using descriptive analysis method. The result shows that in that literary works food functions as: 1) arena for socialization and solidarity; 2) identity marker, both for social and self identity; 3) social class marker; and 4) arena for negotiation for global and local culture. Keywords: food, symbolic function, children’s writing METAFORA MAKANAN DALAM SASTRA ANAK INDONESIA SERI KKPK AbstrakMakanan merupakan salah satu elemen penting yang mampu mengungkapkan dinamika masyarakat, kepercayaan, ideologi, dan nilai-nilai. Hubungan antara makanan dan sastra tidak terelakkan lagi karena makanan merupakan bagian dari budaya, sehingga hubungan karakter dalam suatu karya sastra seringkali melibatkan makanan.Tulisan ini bertujuan menelaah fungsi simbolik makanan dalam tulisan anak Indonesia seri Kecil-Kecil Punya Karya (KKPK) : Let’s Bake Cookies karya Izzati, Egg Ice Cream karya Alifia, dan Resep Baru karya Haura. Payung teori yang digunakan adalah teori dari Roland Barthes yang menyatakan makanan sebagai sistem tanda yang diaplikasikan dalam konteks sastra anak Indonesia. Selain itu, teori Bourdieu mengenai ranah produksi kultural juga diterapkan untuk menganalisis situasi sosial, budaya, dan produksi di luar karya sastra. Membaca teliti (close- reading) digunakan untuk mengumpulkan data. Data tersebut ditabulasi dan kemudian dianalisis melalui pendekatan sosiologis dan menggunakan metode deskriptif analisis. Hasil menunjukkan bahwa dalam karya-karya sastra anak tersebut makanan berfungsi sebagai: 1) ajang untuk sosialisasi dan solidaritas; 2) penanda identitas, baik identitas sosial dan identitas diri; 3) penanda kelas sosial; dan 4) sebagai ajang negosiasi budaya global dan lokal. Kata kunci: makanan, fungsi simbolik, sastra anak
Clinical Applications of Mobile Health Wearable–Based Sleep Monitoring: Systematic Review
Authors: Guillodo Elise , Lemey Christophe , Simonnet Mathieu , Walter Michel , Baca-García Enrique , Masetti Vincent , Moga Sorin , Larsen Mark ,   HUGOPSY Network, Ropars Juliette , Berrouiguet Sofian 
Published: October 2019

Background
Sleep disorders are a major public health issue. Nearly 1 in 2 people experience sleep disturbances during their lifetime, with a potential harmful impact on well-being and physical and mental health.

Objective
The aim of this study was to better understand the clinical applications of wearable-based sleep monitoring; therefore, we conducted a review of the literature, including feasibility studies and clinical trials on this topic.

Methods
We searched PubMed, PsycINFO, ScienceDirect, the Cochrane Library, Scopus, and the Web of Science through June 2019. We created the list of keywords based on 2 domains: wearables and sleep. The primary selection criterion was the reporting of clinical trials using wearable devices for sleep recording in adults.

Results
The initial search identified 645 articles; 19 articles meeting the inclusion criteria were included in the final analysis. In all, 4 categories of the selected articles appeared. Of the 19 studies in this review, 58 % (11/19) were comparison studies with the gold standard, 21% (4/19) were feasibility studies, 15% (3/19) were population comparison studies, and 5% (1/19) assessed the impact of sleep disorders in the clinic. The samples were heterogeneous in size, ranging from 1 to 15,839 patients. Our review shows that mobile-health (mHealth) wearable–based sleep monitoring is feasible. However, we identified some major limitations to the reliability of wearable-based monitoring methods compared with polysomnography.

Conclusions
This review showed that wearables provide acceptable sleep monitoring but with poor reliability. However, wearable mHealth devices appear to be promising tools for ecological monitoring.
Tunnekausatiivilauseen argumenttirakenne I
Authors: Huhmarniemi Saara 
Published: October 2019

Tunnekausatiivilauseet luokitellaan usein omaksi lausetyypikseen, johon kuuluu tunnetta tai tuntemusta ilmaiseva verbi (tunnekausatiivi), partitiivisijainen kokija ja nominatiivimuotoinen aiheuttaja. Tunnekausatiivilauseen aiheuttaja- ja kokija-argumenttien asemaa syntaktisessa rakenteessa on pidetty avoimena kysymyksenä ja rakenteen on arvioitu jopa olevan muutoksessa. Tässä artikkelissa käydään generatiivisen kieliopin kehyksessä läpi argumentti-rakenteeseen liittyviä kieliopillisia testejä, jotka koskevat esimerkiksi kongruenssia, anaforien sidontaa ja sanajärjestystä. Testien perusteella voidaan havaita, että kun tunnekausatiivilauseen aiheuttaja on NP, se sijaitsee tyypillisesti argumenttirakenteessa ylempänä kuin partitiivimuotoinen kokija. Tätä tulosta verrataan Suomi24-korpusaineistosta tehtyihin havaintoihin, joiden perusteella kokija esiintyy useammin verbin edellä kuin aiheuttaja. Tunnekausatiivilauseen sanajärjestyksen vaihtelun katsotaan olevan sidoksissa puhetilanteeseen ja argumenttien ominaisuuksiin.
Tämä artikkeli on osa kahden artikkelin sarjaa. Sarjan toisessa osassa tarkastellaan lausemaisten aiheuttajien asemaa tunnekausatiivilauseen argumenttirakenteessa.

The argument structure of the Finnish experiencer construction I: An NP causer
This article investigates the Finnish experiencer construction, which involves a psychological predicate and two optional arguments: the nominative causer and the partitive experiencer. The argument structure of the Finnish experiencer construction has ­remained an open question in syntactic theories. In this paper, several grammatical tests concerning congruence, binding and word order are applied in the framework of generative syntax. They suggest that when the nominative causer is an NP, it typically occupies a higher position in the argument structure than the partitive experiencer. This result is evaluated against data from the Suomi24 corpus, which reveals that the partitive experiencer occurs preverbally more frequently than the nominative causer. The article asserts that the word order of the Finnish experiencer construction reflects contextual factors and discourse features of the arguments.
This article is the first in a series of two. The second article investigates experiencer constructions with an embedded clause as a causer argument.
Gatti, Gabriel (editor) (2017). Desapariciones: usos locales, circulaciones globales. Bogotá: Siglo del Hombre Editores, Universidad de los Andes, 285 pp.
Authors: Robledo Silvestre Carolina 
Published: October 2019

Reseña del libro
Gatti, Gabriel (Editor), Desapariciones: usos locales, circulaciones globales, Bogotá: Siglo del Hombre Editores, Universidad de los Andes, 2017, 285 p.
Objetividad y discurso en las ontologías de Laclau y Žižek: controversias entre la abundancia y la falta
Authors: Reartes Miguel David 
Published: October 2019

En este trabajo intentaremos reconstruir la noción de discurso de Ernesto Laclau, buscando con ello dar cuenta del modo en que se configura el registro de la objetividad en de las distintas etapas de su propuesta teórica. Al mismo tiempo, buscaremos establecer un contrapunto entre la perspectiva de Laclau y el abordaje que realiza Slavoj Žižek de esta misma dimensión. Intentaremos inscribir el debate entre ambos autores en el marco de la distinción formulada por Tønder y Thomassen entre las ontologías de la falta y las ontologías de la abundancia, con el objetivo de indagar en torno a algunas de las controversias que atraviesan al proyecto teórico de Laclau en su intento por articular ambas orientaciones.
O livro didático de educação física: uma leitura da produção acadêmica | The physical education textbook: A reading of the academic production
Authors: Melo Fernando Garcez de , Moreira Evando Carlos 
Published: October 2019

O objetivo do trabalho é reunir e interpretar a produção acadêmica (teses e dissertações) acerca do livro didático de educação física. Focalizou-se o período entre 1987 e 2018, utilizando as informações do Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. A justificativa reside na recente inclusão da educação física no Programa Nacional de Livro e Material Didático e a necessidade de encontrarmos subsídios para o acompanhamento desse processo de implementação e os desdobramentos no âmbito da prática docente da educação física. Tendo como referência o pragmatismo de Richard Rorty para recontextualizar a produção e apresentar um novo texto, destacam-se a esperança e os receios presentes nas produções acadêmicas, com realce para um conjunto de trabalhos “exploradores do potencial do livro didático” que possui esperança nas maneiras experimentais e humildes. Essa conjuntura de trabalho se diferencia de outro grupo (os “analistas de conteúdos”), crentes nas maneiras teóricas amplas de encontrar justiça e a verdade. Por fim, sugere-se outro ponto de vista aos professores de educação física, para que possam receber os livros didáticos da área com afeição a uma esperança humilde e experimentalista identificada, em especial, no grupo que será denominado “exploradores do potencial do livro didático”.
Qualificação profissional e as políticas educacionais para a juventude no Brasil | Professional qualification and educational policies for the youth group in Brazil
Authors: Lira Jailton De Souza , Santos Sayarah Carol Mesquita dos 
Published: October 2019

Este artigo pretende discutir as proposições de políticas educacionais para a juventude brasileira, especialmente relacionada à expansão da Educação Profi ssional que podem ser notadas no Plano Nacional de Educação (2014-2024) e na atual reforma do Ensino Médio. Como referencial teórico, foram utilizadas as análises situadas no campo do materialismo histórico e dialético de base marxista, à luz das categorias analíticas de “Estado”, com base em Engels e Mészáros, da relação entre “trabalho” e “educação”, segundo Saviani, e de “classe social” fundamentada em Marx e Mészáros. Entende-se que a Educação Profissional pensada a partir da análise das legislações e políticas educacionais adotadas apresenta complexos problemas no quesito do papel do Estado para com a sua oferta e qualidade. Além disso, essa modalidade de educação tem perpetuado o dualismo histórico na educação, que oferta uma formação prática para a juventude de origem trabalhadora e destina uma formação mais ampla possível para a juventude oriunda das classes dirigentes. Para fundamentar essas hipóteses, recorreu-se à pesquisa documental, utilizando a Lei n°13.415/2017 da reforma do Ensino Médio e o Plano Nacional de Educação (2014-2024), bem como a revisão de literatura a partir de autores como Frigotto, Krawczyk, Adrião e Pinto, Bezerra e Araújo, entre outros, que contribuem para as reflexões e contextualizações acerca da relação entre educação, Estado, sociedade e mercado.
Educação em comunidades amazônicas | Education in Amazonian communities
Authors: Matos Gláucio Campo Gomes , Rocha Ferreira Maria Beatriz 
Published: October 2019

O artigo traz uma reflexão sobre a educação nas comunidades amazônicas, mai especificamente naquelas localizadas às margens dos rios do Estado do Amazonas. A pesquisa está alicerçada na teoria de Norbert Elias e no trabalho de campo de cunho etnográfi co. Osamazônidas representam uma miscigenação oriunda de diferentes grupos étnicos e vivem em condições sui generis, adaptados ao clima quente e úmido e ajustando-se às variações dos períodos de enchente e vazante do rio, e aos períodos da chuva e estiagem. Cultivam pequenos roçados para subsistência, praticam o extrativismo, organizam-se em atividade coletiva denominada de “puxirum”, cujo objetivo é a ajuda mútua, e têm acesso à educação institucionaliza advinda das escolas de características urbanas. O conhecimento “tradicional” utilizado na vida diária nessas comunidades tem raízes nas culturas ancestrais dos povos indígenas, mas foi sendo ressignificado de forma interconectada aos processos de mudanças sociais. A educação escolarizada faz parte desse arcabouço do conhecimento e nos últimos anos tem caminhado a passos largos no universo amazônico, muitas vezes sem valorizar o saber fazer do amazônida. O desafio na educação das comunidades ribeirinhas é considerar a importância do conhecimento da vida diária e introduzi-lo no conteúdo da educação institucionalizada, pois foi ele, ao longo dos séculos, a permitir a manutenção da vida desses grupos humanos no universo amazônico.
Civilização e habitus fronteiriço na obra de José de Melo e Silva |Civilization and frontier habitus in the work of José de Melo e Silva
Authors: Ferreira André Soares 
Published: October 2019

O presente artigo visa refl etir sobre aspectos constituintes do habitus fronteiriço a partir das obras “Fronteiras guaranis” e “Canaã do Oeste”, de José de Melo e Silva. As referidas obras integram o corpus historiográfico sul-mato-grossense e revelam elementos integrantes doprocesso civilizador da fronteira Brasil-Paraguai. Utiliza-se a Teoria dos Processos Civilizadores, desenvolvida pelo sociólogo alemão Norbert Elias, como aporte teórico. Habitus, entendido como segunda natureza, desenvolve-se no processo histórico-social que se constitui o desenvolvimento das diversas sociedades marcadas por fi gurações interdependentes. Compreende-se que ohabitus fronteiriço criticado por Melo e Silva na década de 1930, revela aspectos da constituição e dos processos civilizadores da fronteira Brasil-Paraguai. Suas observações revelam as interdependências dos processos sociais e o caráter histórico e social da constituição da identidade regional. Conclui-se que o processo civilizador fronteiriço está em curso e que as relações interdependentes entre brasileiros e paraguaios, descendentes guaranis, produziram um habitus distinto e característico da região.
Fractured Identities of Women in Partition in Manto’s Short Stories ‘Cold Meat’ and ‘Open it!’
Authors: Gupta Priyanka , Dwivedi Amitabh Vikram 
Published: October 2019

Saadat Hassan Manto chronicled the chaos that prevailed, during and after the separation of the subcontinent in 1947. No part of human existence remained untouched or taboo for him. Manto’s short stories debate about various issues and of them women issues are one of them. He sincerely brought out stories of prostitutes and pimps alike, just as he highlighted the subversive sexual slavery of the women of his times. His concerns on the socio-political issues, from local to global level are revealed. The focus of this paper will locate the simulated portico prevailing in the society related to women and their unsettling fractured identities in the society with respect to post colonial aspect. This paper primarily discusses about these two short stories Cold meat and Open it with reference to the women’s position. The splintered identities of women are taken into consideration and the study of two different short stories is premeditated in this paper.
A Study On Determining The Various Human Resources Involved In The Process And Procedures Of Organ Transplantation – Literature Review
Authors: KALAISELVI M. , KARUPPAIYAN S. 
Published: October 2019

Human Resource Management include right from lower, middle and top level management and all unskilled, skilled, clerical, technical, managerial and professional employees of an organisation. A successful health care management is achieved by a proper human resources planning. The study will reveals the various human resources involved in the process of organ transplantation. The process involved in organ procurement and transplantation is very complex that requires multidisciplinary coordination and teamwork.
PENGGUNAAN ATRAKTOR UMPAN CACING TANAH (Lumbricus rubellus) TERHADAP HASIL TANGKAPAN BAGAN APUNG DI TELUK PALABUHANRATU
Authors: Imaduddin Azhari , . Zulkarnain , Iskandar Mokhamad Dahri 
Published: October 2019

Penelitian ini bertujuan untuk menentukan komposisi hasil tangkapan, frekuensi hauling dan pengaruh atraktor umpan cacing tanah terhadap hasil tangkapan bagan apung. Metode penelitian yang digunakan adalah experimental fishing dengan melakukan kegiatan operasi penangkapan sebanyak 20 kali ulangan (trip) di lapangan. Analisis yang digunakan yaitu analisis deskriptif dan uji Mann Whitney. Hasil penelitian menunjukkan bahwa berat total hasil tangkapan bagan apung perlakuan yakni 1401,1 kg dengan 13 jenis ikan dan bagan apung standar tanpa atraktor umpan 545,5 kg dengan 8 jenis ikan selama 20 ulangan (trip). Selanjutnya untuk melihat adanya perbedaan frekuensi hauling antara kedua bagan apung digunakan uji statistik Mann Whitney yang menunjukkan nilai P value atau Asymp Sig. (2-tailed) (0.09 > 0,05). Hal ini dapat disimpulkan bahwa tidak adanya perbedaan atau pengaruh yang signifikan terhadap hasil tangkapan kedua bagan apung pada taraf kepercayaan 95%. Akan tetapi penggunaan atraktor umpan cacing tanah memiliki pengaruh yang signifikan terhadap berat hasil tangkapan bagan apung dengan nilai Asymp Sig. (2-tailed) (0,03 < 0,05) pada taraf kepercayaan 95%.Kata kunci : Atraktor umpan cacing tanah, kantong umpan, light fishing, komposisi hasil tangkapan bagan apung Palabuhanratu, waktu hauling, jumlah hauling