bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapamycin Overproduction by Combined Mutational Study
Authors: Dutta Subhasish , Dey Apurba 
Published: November 2019

Background:
It is a great challenge for scientists to overcome the barrier of Antibiotic resistance
by imparting new technologies to form structurally unique and robust antibiotics in an economically
scalable way. Rapamycin is a well-known macrolide with numerous applications in the
medical field. It is one of the most effective and efficient immunosuppressant antibiotic available in
recent history. With the increase of its application, decreasing its production cost stands as one of the
most critical challenges. Therefore, the selection of a suitable and potent strain of higher yield has
emerged to be of great necessity in the present scenario.

Methods:
Spores prepared from lyophilised culture when treated with different exposure to UV light,
showed a decrease in survival rates in comparison to the untreated sample. Combined treatment of
spores with UV mutagenesis and chemical mutagen (NTG) was done. Spores were incubated at 30°C
at 120 rpm for 2 hr, and some of them were found viable after the treatment. Agar-disc diffusion
method, turbidimetric assay and HPLC analysis were carried out to study the rapamycin concentration
by potent strain.

Results:
Macrolide production was seen to be maximum on the 11th day of fermentation which is 1.76
folds higher as compared to wild type Streptomyces hygroscopicus in shake flask. Structural confirmation
and conformation study were supported by the Nuclear Magnetic Resonance (NMR) technique.

Conclusion:
The maximum amount of antibiotic produced was observed to be 284 mg/L.
IOT Energy Consumption Based on PSO-shortest Path Techniques
Authors: Wadday Ahmed G. , Al-hchaimi Ahmed A.J. , Ibrahim Ahmed J. 
Published: November 2019

Background:
The Internet of Thing is a network that enables multiple hardware devices,
sensors and other home applications from electronically communicate with each other. New era
such technology is increasing importance mainly due to the revolutionary development of information
technologies.

Methods:
However, energy efficiency is still a big challenge facing IoT technology. Thus, it becomes
an interesting topic for many researchers to investigate. Current work aims to reduce the energy
consumption thereby introducing the shortest path technique and another new practicing for
Particle Swarm Optimization algorithm in the Internet of Thing cooperative clusters.

Results:
The main concept is based on cluster heads cooperation with each other known as Cooperative
Clusters to transfer information to the base station. The Primary results reveals a 17% and
16% reduction in energy consumption was achieved over the shortest path technique and Particle
Swarm Optimization algorithm respectively. Results also show a remarkable improvement in the
system lifetime due to the new applied scheme.

Conclusion:
The other method is by PSO algothrim at beginig it sending Randomly then it will select
the path by using the feed back acknowledgment after that it will collect the information by
sending it for the Cluster heads by updating the information status automatically. That’s why we
discovered the PSO advantages than the others.
Application of Voltage and Lines Stability Index for Optimal Placement of Wind Energy with a System Load Increase Scenario
Authors: Wartana I. Made , Agustini Ni Putu 
Published: December 2019

Background:
Modern power system operations often faced with very unsafe conditions
caused by voltage stability problems. If the problem cannot be controlled with the right method, then
a cascade system can occur. This condition can cause a voltage reduction drastically and leads to a
power outage.

Objective:
The Fast Voltage Stability Index (FVSI) and Line Stability Factor (LQP) implemented in
this study. Both indices can determine the optimal location and capacity of Wind Energy (WE) into
the grid to anticipate a sustained increase in load.

Method:
One type of optimization method, a new variant of Genetic Algorithms, is used to solve the
multi-objective optimization problem known as Genetic Algorithm Sorting Non-Domination Sorting
II (NSGA-II). This algorithm can determine the optimal location and WE's capacity into the grid by
minimizing line power loss (Ploss) of power system with a system load increase scenario. Bus voltage
security, thermal line limits, and stability system are used as obstacles to maintain the system in a
safe condition due to the increasing the maximum load.

Results:
The method suggested in this paper has been adequately tested on modification of the IEEE
14-bus standard test system connected to the WE. The WE integrated into the grid modeled using the
Power System Analysis Toolbox (PSAT). Based on the multi-objective manner, the method developed
can determine the best location and capacity of the WE simultaneously by minimizing Ploss with
SLI and satisfied all the system's security and stability constraints.

Conclusion:
The technique provides well-distributed non-dominated solutions and well exploration
of the research space.
Iot Secured Disjunctive XOR Two Factor Mutual Authentication for Users
Authors: Talwar Meenu , Balusamy Balamurugan 
Published: November 2019

Aims:
The paper has introduced an algorithmic modification of M.L.Das's previous work
done of " IoT Mutual Authentication".

Background:
IoT has proven that if there exists a thing on the earth then it is bound to be connected
to the internet to tell its feature on its own. IoT plays a remarkable role in all aspects of our daily
lives it covers entertainment, sports, healthcare, education, security, automobiles, industrial as well
as home appliances and many more real time applications. To ease our everyday activities, it reinforcing
the way people interact with their surroundings. This holistic view brings some major concerns
in terms of security and privacy.

Objective:
The objective of the work is to increase security and protect the algorithm from various
attackers so to use with real time application.

Methods:
In this we have used XoR (Exclusive OR) operation and because of this we can protect the
algorithm from DoS attacks, bypass attack, intruder attack and allow user to change password.

Conclusion:
The proposed work has secured all the connected IoT devices to work inde-pendently and
secured because every device has to verify at each step in the IoT system before initiating its operation.
Análise da implementação dos Institutos Federais de Educação no Piauí: escolha de municípios e cursos
Authors: Tavares da Silva Neto José , De Oliveira Passos Guiomar 
Published: December 2019

Examina-se o processo de expansão da Rede Federal de Educação Profissional, Científica e Tecnológica no estado do Piauí. Investiga-se a escolha dos municípios beneficiados com a implantação de campi e dos cursos ofertados pelos mesmos, inquirindo-se sobre a adequação do processo de expansão da rede federal de educação profissional e tecnológica no Piauí às diretrizes governamentais postas para a mesma, no que concerne à distribuição das unidades de ensino pelo território piauiense e à escolha dos cursos ofertados. Procede-se uma analise de política pública na fase de implementação, segundo o ciclo de vida da mesma, examinando sua engenharia institucional e os traços constitutivos dos programas dela decorrentes, analisando suas escolhas, verificando se estas observaram as diretrizes e intenções estabelecidas pelo formulador. Verificou-se que as escolhas realizadas, em alguns momentos, distanciaram-se do marco normativo, embora não colidindo na totalidade com o mesmo; em outras, aproxima-se dele, demonstrando a persecução do implementador às diretrizes postas. Palavras-chave: administração estadual, administração da educação, ensino superior, capacitação profissional, estudo de caso.
A Percepção dos Contadores Públicos em Relação às Normas Brasileiras de Contabilidade Aplicadas ao Setor Público – NBCASP
Authors: Piccoli Marcio Roberto , Klann Roberto Carlos 
Published: December 2019

O estudo objetiva identificar a percepção dos contadores públicos em relação às Normas Brasileiras de Contabilidade Aplicadas ao Setor Público (NBCASP), a partir de um questionário estruturado, enviado aos profissionais dos Municípios da Região da Associação de Municípios do Meio Oeste – Ammoc, SC. A pesquisa, do tipo descritiva, foi dividida em três blocos: o primeiro buscou identificar o perfil do profissional, no segundo abordou-se os problemas enfrentados pelos profissionais quanto à adaptação às normativas e, no terceiro, o entendimento sobre as NBCASP. O estudo revelou ainda que 50% dos entrevistados não possuem amplo conhecimento sobre as NBCASP. As maiores deficiências estão nos procedimentos a serem adotados a partir das normas 16.9 e 16.10. Conclui-se assim que a nova contabilidade pública é importante para a transparência e controle das contas públicas, mas, por outro lado, os contadores ainda não estão aptos a elaborar e analisar as demonstrações contábeis.
Política de assistência social e coordenação federativa no Brasil
Authors: Soares Márcia Miranda , Cunha Edite da Penha 
Published: December 2019

O artigo analisa a política de assistência social no âmbito da organização federativa do Estado brasileiro. Para isso, apresenta e discute as transformações ocorridas na assistência social em sua configuração atual, da Constituição de 1988 até o período atual. A política de assistência social se assenta na afirmação de direito universal a ser efetivado pelo Estado, de forma integrada com outras políticas sociais e coordenada entre os entes governamentais, devendo contar com a participação da sociedade. O foco do trabalho para entender as mudanças e perspectivas atuais para a assistência social é o Estado federal, configurado por relações intergovernamentais mediadas por escassos recursos de interlocução e articulação federativa e pelo amplo papel indutor da União. É nesse contexto que se apresentam alguns desafios para o avanço da política: financiamento governamental; maior envolvimento dos estados; baixa capacidade gerencial dos municípios e o aumento da participação social.
Delivering a Post-Partum Weight Loss Intervention via Facebook or In-Person Groups: Protocol for a Randomized Feasibility Pilot Trial
Authors: Waring Molly E , Libby Brooke A , Moore Simas Tiffany A , Bracken Madison L , Bibeau Jessica L , Herrera Valeria , Wang Justin , Pagoto Sherry L 
Published: November 2019

Background
Postpartum weight retention contributes to long-term weight gain and obesity for many women. Lifestyle interventions with numerous visits are logistically challenging for many postpartum women. Delivering a lifestyle intervention via social media may overcome logistic challenges to participation in in-person weight loss programs.

Objective
The objective of this study is to conduct a randomized feasibility pilot trial of a 6-month postpartum weight loss intervention delivered via Facebook or in-person groups with 72 postpartum women with overweight or obesity.

Methods
Women with overweight or obesity who are 8 weeks to 12 months postpartum (N=72) will be recruited from the Hartford, Connecticut community. Eligible participants must also own an iPhone or Android smartphone and be an active Facebook user. Participants will receive a 6-month postpartum weight loss intervention based on the Diabetes Prevention Program lifestyle intervention and adapted for postpartum women. Participants will be randomized to receive the intervention via a private Facebook group or in-person group meetings. Assessments will occur at baseline, weekly during the intervention, at 6 months (at the end of the intervention), and at 12 months. Primary feasibility outcomes are recruitment, sustained participation, contamination, retention, and feasibility of assessment procedures including measurement of costs to deliver and receive the intervention. We will describe 6- and 12-month weight loss as an exploratory outcome.

Results
Recruitment began in September 2018. The first wave of the intervention began in February 2019, and the second wave of the intervention is expected to begin in fall 2019. We anticipate completing follow-up assessments in fall 2020, and results will be analyzed at that time.

Conclusions
Results will inform the design of a large randomized controlled trial to assess whether delivering a postpartum weight loss intervention via Facebook is noninferior for weight loss and more cost-effective than delivering the intervention via traditional in-person groups.

International Registered Report Identifier (IRRID)
DERR1-10.2196/15530
Inovasi Limbah Cair Singkong Menjadi Nata de Cassava Sebagai Bisnis Kuliner
Authors: Permatasari Amaliya Sita , Winaningsih Ima , Prasetiyo Jamal Adi 
Published: December 2019

Cellulose bacterial is cellulose formed by bacteria sugar content in waste. Cassava-based industrial liquid waste contains sugar (5-7)%, so it has the potential as a substrate because it meets the minimum glucose requirements of (6-7)% to form cellulose bacterial. The waste was obtained from liquid waste from home industry cassava rengginang in Nyamok Village. However, liquid waste smells bad because it is directly streamed into the environment. Therefore, the purpose of this activity is to give solutions for overcome environmental pollution and increase the income of cassava rengginang craftsmen in Nyamok Village. The methods are lectures, demonstrations, production training, assistance, and socialization. Liquid waste made from cassava chips was used as raw material for making nata de cassava. It was fermented with Symbiotic Culture of Bacteria and Yeast (SCOBY) bacteria for 10-14 days. Training activities were successful as 86% people participated in the training. The participants were around 40 years old and elementary school graduates. The characteristics of the participants influence their interest and ability to absorb new information. It is proved by 89% of the participants are able to make Nata de cassava and their understanding of the counseling material was above the target of 80%.Keywords: cassava rengginang; nata de cassava; production training; SCOBY.
Application of Bio Fertilizer and Biogas Sludge to Curly Red Chili (Capsicum annuum L.) at Wukirsari Village, Cangkringan, Sleman
Authors: Siswanti Dwi Umi , Utaminingsih Utaminingsih , Lestari Melinda Fajar , Hamdian Hamdian 
Published: December 2019

Curly red chili (Capsicum sp.) is an important agricultural commodity in Indonesia. The pattern of conventional cultivation using inorganic fertilizers has caused high production costs. While the level of spiciness of chili determined by capsaicin levels is strongly influenced by nutrients in the growing media. Bio fertilizer and sludge biogas biogas which is one of the organic fertilizers proved to be able to increase the growth and productivity of rice plants. This study aimed to analyze growth parameters, chlorophyll content and measure capsaicin levels in curly red chili. Which given bio fertilizer and biogas sludge biogas in various dosage and determine the optimum dose of the fertilizer. The study was conducted at an agricultural demonstration plot in Wukirsari Village, Cangkringan, Sleman. The study design used RCBD (Randomized Complete Block Design), the data were analyzed by ANOVA (Analysis of Variance followed by Duncan's multiple distance test (DMRT) at the 95% confidence level. The highest growth parameters was obtained on curly red chili plants which were given sludge biogas 36 mL + bio fertilizer 10 L / ha. Thus, it can be concluded that the most appropriate dose of curly red chili is 36 mL sludge biogas + bio fertilizer 10 L/ha.Keywords: Bio-fertilizer; biogas; chili; growth;sludge; Wukirsari.
PERTUMBUHAN BERBAGAI VARIETAS KEDELAI (Glycine max L. Merril) PADA TANAH ULTISOL KABUPATEN ACEH TENGGARA
Authors: Tambunan Syariani Br. , Afkar Afkar 
Published: December 2019

This study aims to determine the growth of various soybean varieties on Ultisol soil, especially on Ultisol soils in Kutacane. The study was conducted in Gulo Village, Darul Hasanah District, Southeast Aceh Regency, Aceh Province with hilly topography, from May to September 2019 at an altitude of 3200 asl. The study used a Non Factorial Randomized Block Design (RBD), with 4 treatment varieties (V) repeated in 4 replications with 63 plants per plot with 7 samples per plot. The plot size is 3 m x 2 m with 30 x 20 cm spacing. The total number of plants was 1008, while the total number of sample plants was 112 plants. There are 4 soybean varieties: (V1) Anjasmoro, (V2) Dena1, (V3) Deja 1, and (V4) Detap 1. The parameters observed in this study during vegetative period include plant height at 1, 2, 3, 4, 5, and 6 week after planting. The plant height were measured from the base of the stem to the highest leaf. The result is that each variety has a different response to the environment so that the growth, flowering period, and harvest period are also different on Ultisol soil especially in District of Southeast Aceh.
HUBUNGAN KARAKTER DISIPLIN DAN TANGGUNG JAWAB TERHADAP NILAI AKHIR MAHASISWA CALON GURU (Studi pada Mahasiswa Pendidikan Jasmani Kesehatan dan Rekreasi FKIP Unsyiah dan Mahasiswa PendidikanBiologi FTK UIN Ar-Raniry)
Authors: Masri Masri , Taib Eva Nauli 
Published: December 2019

The purpose of this study is to determine the relationship between the discipline and responsibility to the student's final grade. This study is an ex post facto research with population of Physical and Health Education students. The sample number is 100 students using a purposive sampling technique. The data was analyzed using the correlation and regression formula. The results of data analyzing is that r1 = 0.87, r2 = 0.4, R1 = 0.67, r3 = 0.68, r4 = 0.79 and R2 = 0.77. It can be concluded that there is a significant relationship between the discipline and the responsibilities towards the final grades of the Physical and Health Education students.
Association between levodopa and ischemic heart disease
Authors: Orayj Khalid , Lacey Arron , Akbari Ashley , Smith Mathew , Pickrell Owen , Lane Emma 
Published: November 2019

Background Several studies linked the use of levodopa to an increase in homocysteine level, which can lead eventually to ischemic heart disease (IHD) in Parkinson’s disease (PD) patients. There is a lack of large population studies that have investigated the cardiovascular safety of levodopa.
Objectives The main objective of the study is to investigate the one-year risk of IHD hospitalisation, all-cardiovascular hospital hospitalisation, and all-cause mortality among users of L-dopa compared with users of Monoamine oxidase B (MAO-B) inhibitors (as a reference).
Methods A population-based study evaluated data obtained from the Secure Anonymised Information Linkage (SAIL) Databank of residents in Wales, aged 40 years or older, newly treated with PD medications between 2000 and 2016. The General Practice (GP) database was used to identify the PD diagnostic codes, PD medications, and other medications used by PD patients. Hospital data were used to identify the first hospitalisation event (IHD and other cardiovascular events). A fully adjusted propensity score multivariate Cox regression analysis was used to examine associations between levodopa and the study outcomes. The index date was set at the date of the first PD prescription in the newly diagnosed PD patients. Other variables included gender, comorbidities, social deprivation score and previous medications history were controlled for.
Findings There were 5,140 participants on levodopa and 494 on MAO-B inhibitors. L-dopa was not associated with IHD (p=0.561), other cardiovascular events (p=0.233), or all-cause mortality (p=0.334). For IHD, the lack of difference was seen also in the unadjusted model and in the age-only adjusted model.
Conclusion This study has shown that L-dopa does not increase the risk of IHD, cardiovascular risk, or all-cause mortality in the newly diagnosed PD patient within one year after the therapy initiation. This could contribute to the safety profile of L-dopa therapy. Future research with a longer follow up period is warranted.
The Welsh Government Flying Start Data Linking Project
Authors: Herbert Laura , Whiffen Tony , Lowe Sarah , Solomons Craiger 
Published: November 2019

Background with rationale Flying Start is the Welsh Government’s (WG) flagship Early Years programme for families with children aged less than 4 years of age. Running since 2006, the four entitlements are:

Enhanced Health Visiting
Free part-time childcare for 2-3 year olds
Parenting support
Speech, language, and communication support

Previous Flying Start evaluations have focused on area-based analysis to explore outcomes of Flying Start eligible children. The current project is the first to obtain individual level Flying Start data to look at outcomes around health, education and social care and to explore these outcomes in relation to levels of engagement with different entitlements of Flying Start.
Main Aim The aim of the project is to link individual-level Flying Start intervention data with health, education and other data to investigate the potential impact of Flying Start.
Methods/Approach Individual level data for Flying Start children is currently being obtained from six pilot Local Authorities in Wales using the Secure Anonymised Information Linkage (SAIL) databank.
The Flying Start data will be linked to other data within the SAIL databank in order to investigate the impact of the Flying Start programme on a number of different outcomes including hospitalisations, Accident & Emergency (A&E) attendances, Primary Care interactions, educational attainment, school attendance and Special Educational Needs (SEN).
Results The project will report on the emerging findings from the analysis of pilot data. It is anticipated that Flying Start dosage effects will also be investigated and reported on.
Conclusion The findings will feed into the current evidence base for Flying Start and help to inform future policy-making. If successful, this model of evaluation is likely to be adopted by related WG programmes.
Scottish Burden of Disease (SBOD) study: developments and findings of local estimates
Authors: Wyper Grant , Grant Ian , Fletcher Eilidh , McCartney Gerry , Stockton Diane 
Published: November 2019

BackgroundA criticism of Burden of Disease (BOD) estimates has been that they only provide evidence for national policy and aren’t relevant for local needs. This has led to a growing call for BOD studies to provide more granular estimates for sub-national geographies, particularly within European countries, to help support local policy makers with evidence-based decision making.
AimTo develop local BOD estimates and investigate inequalities in BOD within and across local areas of Scotland.
MethodsEstimates of Years Lived with Disability (YLD), Years of Life Lost (YLL), DALYs (Disability-adjusted Life Years), prevalent cases and mortality counts were developed for 68 conditions. Morbidity estimates were calculated based on a three-year average of 5-year age-group, sex and deprivation decile rates per person (from the SBOD 2016 study) which were applied to 2016 mid-year local population estimates. Mortality estimates were based on a three-year average (2014-16) sourced from the National Records of Scotland register of deaths. Direct age-standardised rates and numbers were produced for regions (3), NHS boards (14) and local authorities (32) by age-group and sex.
ResultsAcross local authorities the male rate of all-cause DALYs ranged from 20,996 (per 100,000 population) to 33,442 and the female rate of all-cause DALYs ranged from 19,889 to 27,684. Inequalities in age-group (15-24; 25-44; 45-64; and 65+ years) differences between all-cause DALYs rates in the area with the highest and lowest rates ranged from 58.4% to 98.0% in males. Comparable estimates were slightly lower for females, but inequalities in rates were wider (41.4% to 87.4%).
ConclusionInequalities in BOD across areas highlight the need for action at all levels. These local estimates provide a huge opportunity to work towards and beyond the 2020 vision of the Scottish Government by ensuring that we have the right workforce and services to achieve a healthier Scotland.