bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОСОБЛИВОСТІ ФОРМУВАННЯ ПОКАЗНИКІВ ЛІКВІДНОСТІ У ПОРТФЕЛЬНОМУ МЕНЕДЖМЕНТІ ФІНАНСОВИХ ІНСТИТУТІВ
Authors: Шевченко Дмитро 
Published: December 2020

Присвячено обґрунтуванню теоретико-методологічних засад і розробленню науково-практичних рекомендацій щодо особливостей формування показників ліквідності у портфельному менеджменті фінансових інститутів. Обґрунтовано сутність категорії «ліквідність» і виявлено її структуру, доведено необхідність її оцінювання. Систематизовано умови низької ліквідності в компаніях, що розвиваються.
На основі статистичних матеріалів Держкомстату України, звітних даних Міністерства фінансів України, матеріалів Світового банку і звітів Всесвітнього економічного форуму проаналізовано ефективність розвитку компаній Європейського Союзу і України. Розглянуто дефiніцію ліквідності фондового ринку та оцінку ліквідності на фондовому ринку і модель, що враховує ліквідність при побудові оптимального інвестиційного портфеля. Також досліджується питання комплексної оцінки ліквідності на фондовому ринку і фактори, що враховують ліквідність при побудові оптимального інвестиційного портфеля.
Дослідження проводилося з використанням таких методів: аналізу і синтезу наукових робіт — при розгляді дефініції ліквідності фондового ринку; економіко-статистичні та оціночні — при аналізі статистичних даних, які характеризують ліквідність ринку; графічного — для наочного подання результатів дослідження; моделювання — при побудові моделі, що враховує ризик ліквідності в портфельній теорії.
ФІНАНСОВИЙ ТА ЕКОНОМІЧНИЙ МЕХАНІЗМИ ЕКОЛОГІЧНО БЕЗПЕЧНОГО ПІДПРИЄМНИЦТВА: ПРАВОВИЙ АСПЕКТ
Authors: Гайович Вадим 
Published: December 2020

Присвячено сутності поняття такого нового виду підприємництва, як екологічне. Наведені різні позиції як українських, так і зарубіжних учених щодо поняття «екологічне підприємництво». На нинішньому етапі розвитку не визначено єдиного універсального поняття, а отже, це означає, що воно в Україні відносно недавно увійшло в науковий обіг і ще вимагає доопрацювання.
Протиріччя між зростаючими потребами населення і деградацією довкілля свідчать про потребу гармонійного поєднання екологічного, економічного і фінансового компонентів розвитку, зміщення акцентів на користь природоохоронної складової у процесі господарювання.
Проаналізовано потенціал законодавчої і нормативної бази та їхню ефективність при стимулюванні розвитку екологічного підприємництва, визначено організаційно-управлінські умови його розвитку в Україні.
Розглянуто теоретичний базис, на якому ґрунтується фінансовий механізм природоохоронної сфери; відображено роль і місце вказаного механізму в межах упровадження фінансової політики держави; висвітлено законодавчі засади, на яких ґрунтується фінансова складова національної екологічної стратегії; проведено аналітичний моніторинг процесів фінансового забезпечення охорони навколишнього природного середовища.
Investigando dificuldades na escrita de alunos em processo de alfabetização
Authors: Sousa Márcia Beatriz da Cruz e 
Published: December 2020

O cenário da educação brasileira tem contribuído para o engessamento das práticas docentes e principalmente, no que se refere ao processo de alfabetização. Salas de aula cada vez mais superlotadas corroboram para práticas docentes homogeneizadoras, ignorando a individualidade do aluno, priorizando o todo e desconsiderando as dificuldades individuais de cada aluno. Entretanto, talvez um olhar mais criterioso do docente das séries iniciais possa contribuir para a alfabetização significativa para o aluno ditos “com dificuldades”. Desta forma o objetivo deste trabalho foi realizar uma investigação in loco pela própria autora no seu próprio ambiente de trabalho a fim de analisar reflexivamente o papel do professor na construção da identidade de “alunos com dificuldades” de aprendizagem de leitura e escrita. A metodologia empregada foi uma investigação reflexiva na qual coletou-se dados sobre os alunos com a coordenadora pedagógica, os pais e a produção escrita de 3 alunos no primeiro ciclo da escola regular pública. Os resultados destacaram o valor da teoria histórico-cultural e a experiência docente que permitiram à professora problematizar o conceito de “aluno com dificuldade” com o intuito de ressignificar a própria prática.
SEMANTISCHE BESCHREIBUNG DER DEUTSCHEN MODALPARTIKELN "JA" UND "DOCH" UND IHRER SERBISCHEN ÄQUIVALENTE
Authors: Nikolić Aleksandar 
Published: December 2020

Der Gegenstand dieser Arbeit sind die deutschen Modalpartikeln ja und doch und ihre Äquivalente im Serbischen. Im Vergleich zur serbischen Sprache ist die deutsche Sprache reich an Modalpartikeln, was, zusammen mit ihren spezifischen Eigenschaften, zu unterschiedlichen Problemen und Schwierigkeiten beim Übersetzen oder Lernen führen kann. Probleme spiegeln sich darin wider, dass es in der Übersetzung aus dem Deutschen ins Serbische oft viele Varianten der gleichen Partikel gibt, unter denen allerdings selten eine vollständige Äquivalenz vorzufinden ist. Ziel dieser Arbeit ist es, die erwähnten Modalpartikeln zu beschreiben und einen Einblick in deren unterschiedlichen Bedeutungen und Anwendungen zu gewährleisten und damit die bestehenden Mängel in diesem Bereich zu reduzieren. Der Fokus dieser Arbeit liegt darin, alle möglichen Übersetzungsvarianten der erwähnten Partikeln im Serbischen aufzufinden und die häufigsten bzw. frequentesten hervorzuheben. Die hierbei angewandten Methoden sind die Methoden der kontrastiven und deskriptiven Analyse. Der Korpus besteht aus den Partikeln ja und doch, die in Heinrich Manns Roman Professor Unrat oder Das Ende eines Tyrannen und der Übersetzung Profesor Unrat ili kraj jednog tiranina vorhanden sind.
O Ensino da história da escravidão no Rio Grande do Sul através de documentos: um relato de experiência
Authors: Machado Vanderlei , Boenavides Dionathas Moreno 
Published: December 2020

O presente relato descreve uma experiência de ensino baseada em documentos sobre a escravidão no Rio Grande do Sul e realizada em turma de EJA do segundo ano do Ensino Médio XXXXXX, no segundo semestre de 2017. No desenvolvimento da atividade foi utilizada a Caixa Pedagógica “AfricaNoArquivo”, disponibilizada pelo Arquivo Público do Estado do Rio Grande do Sul (APERS). A caixa comporta fac-símiles de documentos oficiais sobre a escravidão e outros materiais pedagógicos. Ao aplicar essa atividade buscou-se aprofundar análises sobre a história da escravidão no estado, atendendo à Lei 10.639; colocar as/os estudantes no contato com documentos históricos; demonstrar um pouco do métier da/do historiador/a e auxiliar na compreensão mais complexa de alguns aspectos da história afro-brasileira no período escravocrata. A atividade contribuiu para que os/as estudantes compreendessem como se produz o conhecimento histórico.
Refigurações narrativas discentes nas aulas de História: reflexões sobre aprendizagens dessa disciplina escolar
Authors: Martins Marcus Leonardo Bomfim , Barbosa Alexandre Rodrigues de Frias , Gabriel Carmen Teresa 
Published: December 2020

O objetivo desse artigo é problematizar processos de aprendizagens da História escolar. Situado em uma abordagem pós-fundacional, ele se inscreve nas lutas pela significação e fixação de um sentido particular do ato de aprender História. Em diálogo com autores que nos oferecem pistas para pensar de outro lugar epistêmico o processo de aprendizagem, em geral, e da disciplina História, em particular, o artigo explora a interface de três categorias - relação com o saber, verdade histórica e refiguração narrativa - como chaves de leitura para um entendimento possível desse processo. A empiria é constituída por um conjunto de fragmentos narrativos produzidos por estudantes da educação básica em aulas de História. A análise reafirma a possibilidade de compreensão da aprendizagem histórica para além de aquisições de conhecimentos disciplinares, evidenciando processos multidimensionais que se inscrevem na cultura histórica e na cultura escolar.
Fluvial architecture and paleoenvironmental evolution of the Los Colorados Formation (Norian): Postrift stage of the Ischigualasto–Villa Unión Basin, NW Argentina
Authors: Santi Malnis Paula , Colombi Carina E. , Rothis Luis Martin , Alcober Oscar 
Published: December 2020

ABSTRACTThe last stage of activity of the Ischigualasto–Villa Unión Rift Basin in west-central Argentina is represented by the 1100-m-thick fluvial red-beds of the Los Colorados Formation (Norian). Facies and architectural-element analysis were applied and vertical stacking patterns evaluated in the Los Colorados Formation to develop a depositional model for the postrift stage of basin fill. The Los Colorados Formation is subdivided into eleven stratigraphic intervals, generally characterized by multistory and multilateral channelized bodies interspersed with thick floodplain deposits developed under seasonal semihumid to semiarid climate conditions. The evolution of the fluvial architectural style shows changes in the location of channel facies concentration, in paleocurrents, and sediment provenance from the sixth stratigraphic interval toward the upper part of the Los Colorados Formation. The fluvial architecture observed in the upper part exhibits a drift in paleocurrents from a SE to a NE mean direction, together with a radial pattern in paleocurrent directional data. Thus, the paleoenvironmental evolution of the Los Colorados Formation is interpreted in terms of axial vs. transverse drainage system fluvial architecture under ongoing postrift conditions. While the fluvial architecture of the lower part responds to an axial fluvial system, the upper part is compatible with the entrance of a fluvial transverse drainage system. The role of axial vs. transverse drainage systems is discussed in the Los Colorados Formation paleoenvironmental evolution. Despite the axial system being considered the main sediment feeder of the basin fill in most interpretations of the rock record, our results indicate that transverse drainage systems can play a central role in postrift basin filling, as is proposed in modern examples.
Ampule-sealed Acidolysis for Monosaccharide Composition Analysis of Serum or Plasma Samples
Authors: Zeng Pengjiao , Zeng Xuan , Hao Cui , Chen Yulong , Zhang Yiran , Zhang Meng , Zhang Lijuan 
Published: December 2020

Abstract
This protocol describes the procedures where an ampule-sealed acidolysis is used for releasing glycan monosaccharides from serum or plasma samples. The monosaccharide composition analysis is subsequently obtained by a traditional HPLC method that separates and quantifies all 1-phenyl-3-methyl-5-pyrazolone (PMP)-labeled monosaccharides in 10 μl serum in 55 minutes. The described workflow takes approximately 2 days, up to 26 serum samples can be analyzed with one HPLC instrument per day. Each step of the experimental procedures has been optimized with repeated tests of monosaccharide standards and serum samples.
Microwave Instrument-assisted Acid Hydrolysis plus HPAEC-PAD for Quantitative Glycan Monosaccharide Composition Analysis of Serum/Plasma Samples
Authors: He Yanli , Zhang Yiran , Zhang Lijuan 
Published: December 2020

Abstract
This protocol describes the procedures where our published microwave instrument-assisted acid hydrolysis (MAAH) coupled HPAEC-PAD analysis are optimized for glycan monosaccharide composition analysis of serum/plasma samples. The optimized acid hydrolysis of serum/plasma samples takes only 10 min and 10 μl of acid and 2 μl serum/plasma samples. The monosaccharide composition analysis is subsequently accomplished by HPAEC-PAD analysis. Each step of the experimental procedures has been optimized with repeated tests of monosaccharide standards and serum samples. The described workflow takes approximately 70-90 min, up to 48 serum/plasma samples can be analyzed with one HPAEC-PAD instrument per day.
Visual impairment and its predictors among people living with type 2 diabetes mellitus at Dessie town hospitals, Northeast Ethiopia: Institution-based cross-sectional study
Authors: Seid Mohammed Abdu , Ambelu Adugnaw , Diress Mengistie , Yeshaw Yigizie , Akalu Yonas , Dagnew Baye 
Published: December 2020

Abstract
Background: Visual impairment (VI) is a functional limitation of the eye(s) that results in reduced visual acuity, visual field loss, visual distortion, perceptual difficulties, or any combination of the above. Type 2 diabetes mellitus (T2DM) is one of the common causes of visual impairment. No study was conducted in Ethiopia to determine the prevalence of visual impairment and its predictors among people living with T2DM. Therefore, the current study aimed to determine the prevalence and predictors of visual impairment among people living with T2DM at Dessie town Hospitals, Northeast Ethiopia, 2020.Methods: Institution-based cross-sectional study was carried out from 15 February to 15 March 2020 using simple random sampling technique to recruit study participants among people living with T2DM. Visual impairment was measured using visual acuity test. We used Epi-Data 3.1 and SPSS version 22 for data entry and statistical analysis, respectively. Bi-variable binary logistic regression was performed to check independent association of each factor with visual impairment. After selecting candidate variables at p<0.25, we computed multivariable binary logistic regression to identify statistically significant factors of visual impairment. The degree of association was determined using adjusted odds ratio (AOR) with 95% confidence interval. In the final model, statistical significance was declared at p ≤0.05.Results: Three hundred and twenty-two people living with T2DM participated in this study with 97% response rate. The prevalence of visual impairment was 37.58% (95% CI: 32.3, 42.9). Age (AOR: 1.06, 95% CI: 1.02, 1.09, p≤0.001), poor regular exercise (AOR=2.91, 95%CI: 1.47-5.76, p≤0.001), duration of DM above 5 years (AOR=2.42, 95% CI: 1.25-4.73, p≤0.01), insulin treatment (AOR=14.05, 95% CI: 2.72, 72.35, p≤0.01), and poor glycemic control (AOR=2.17, 95% CI: 1.13-4.14, p≤0.05) were statistically associated with visual impairment.Conclusion: The prevalence of visual impairment in Dessie town hospitals accounted for more than a third of patients living with T2DM. Visual impairment is associated with increased age, poor regular exercise, longer duration of DM, and insulin treatment. Thus, early detection of VI through screening and regular follow-up is recommended to reduce the risk of VI and vision loss.
Total rupture of achilles tendon induces inflammatory response and glial activation on the mice spinal cord&nbsp;
Authors: Paula Diego De , França Martha , Leão Luana , Maciel Analú , Moura Thalita , Moraes Suellen , Bahia Carlomago , Borges Rosivaldo , Batista Evander , Passos Adelaide , Oliveira Karen , Herculano Anderson 
Published: December 2020

Abstract
Rupture of Achilles tendon is a common accident affecting professional and recreational athletes. Acute and chronic pains are symptoms commonly observed in ruptured patients. Despite that, no studies have described whether Achilles tendon rupture is able to promote disorders in CNS. Based in these finds, the current study aimed to evaluate nociceptive alterations and inflammatory response in L5 lumbar segment of Balb/c mice spinal cord after Achilles tendon rupture. We demonstrated increased algesic response in the paw of ruptured group on the 7th and 14th days post tenotomy when compared with control group. This phenomenon was accompanied by over expression of COX-2 and NOS-2 as well as hyperactivation of astrocytes and microglia in nociceptive areas of L5 spinal cord as evidenced by intense GFAP and IBA-1 immunostaining, respectively. Biochemical studies also demonstrated increased levels of nitrite in the L5 spinal cord of tenotomized animals when compared with control group. Thus, we have demonstrate for the first time that total rupture of the Achilles tendon induces inflammatory response, nitrergic and glial activation in the CNS at L5 spinal cord region.
Serology in COVID-19 – Comparison of Two Methods
Authors: Moniuszko-Malinowska Anna , Jelski Wojciech , Dunaj Justyna , Mroczko Barbara , Czupryna Piotr , Kruszewska Ewelina , Pancewicz Sławomir 
Published: December 2020

Abstract

The aim of our study was to investigate the difference in the anti-SARS-CoV-2 antibodies assessment with two various assays. 127 patients exposed to SARS-CoV-2 were included. Two serological tests were used: SARS-CoV-2 IgG CMIA on the Alinity system (ABBOTT) and LIAISON® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin). Both assays exhibited 96.85% (123/127 patients) overall compatibility. In 2 cases the positive results in N-based test, were negative in S-based test, and in 2 cases negative results in S-based test were positive in N-based test. Based on the results of our study we concluded that the assessment of anti-SARS-CoV-2 antibodies against N and S protein in population medicine shows comparable usefulness of both tests.
Central Retinal Vascular Trunk Deviation in Unilateral Open-angle Glaucoma
Authors: Lee Kyoung Min , Kim Martha , Oh Sohee , Kim Seok Hwan 
Published: December 2020

Abstract
Patients with unilateral open-angle glaucoma (OAG) have suffered glaucomatous optic neuropathy in one eye only despite shared systemic factors between two eyes. It suggests a locoregional susceptibility factor associated with glaucoma development. In this study, we measured the distance of the central retinal vascular trunk from the Bruch’s membrane opening (BMO) center relative to that of the BMO margin: the shift index, since it can be used as a surrogate of lamina cribrosa (LC) shift caused by different growth between retinal and scleral layers during eyeball expansion. The shift index was compared between OAG and fellow control eyes within individuals (129 OAG patients). Although OAG eyes also had higher baseline IOP, a larger β-zone parapapillary atrophy area, a larger shift index was the only risk factor of OAG diagnosis in a generalized linear mixed-effects model. Further, a generalized estimating equation regression model revealed that the shift index was larger in the OAG eyes than in the control eyes for all ranges of axial length, while it was the smallest for the axial length of 23.7 mm. Thus, a larger shift index and LC shift may act as a locoregional susceptibility factor for unilateral OAG eyes.
Efficacy of combination treatment using YHO-1701, an orally active STAT3 inhibitor, with molecular-targeted agents on cancer cell lines
Authors: Taniguchi Keisuke , Konishi Hiroaki , Yoshinaga Akiko , Tsugane Momomi , Takahashi Hiroyuki , Nishisaka Fukiko , Shishido Yoshiyuki , Asai Akira 
Published: December 2020

Abstract
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell growth, survival, and metastasis. STAT3 signaling is constitutively activated in various types of hematologic or solid malignancies. YHO-1701 has been developed as an orally available STAT3 inhibitor. Herein, YHO-1701 in combination with molecular-targeted agents was evaluated. Additive or synergistic effects were observed in a broad spectrum of “combination treatment + cell line” pairs. Of particular interest was the synergistic effect observed when YHO-1701 was combined with imatinib or dasatinib [breakpoint cluster region-abelson (BCR-ABL) inhibitors], osimertinib [epidermal growth factor receptor (EGFR) inhibitor], crizotinib, alectinib, or ceritinib [anaplastic lymphoma kinase (ALK) inhibitors]. The results further showed a close relationship between these synergistic effects and the cellular levels of the key molecules involved in the target pathways for YHO-1701 and each combination drug. The combination of YHO-1701 with alectinib resulted in a significantly greater antitumor activity without exhibiting body weight loss in an NCI-H2228 [echinoderm microtubule–associated protein-like 4 (EML4)-ALK fusion] xenograft mouse model. Our results strongly suggest that the logical strategy in combination with the novel STAT3 inhibitor YHO-1701 and other mechanistically different targeted agents could be a promising approach in the clinical setting.
Endometriosis-Associated Symptoms and Diagnostic Delay: An Online Survey
Authors: Moradi Maryam , Niazi Azin , Parker Melissa , Sneddon Anne , Lopez Violeta , Ellwood David 
Published: December 2020

Abstract
Background: Endometriosis is found in women of all ethnic and social groups with a prevalence of around 10%. However, data on diagnostic-delay and associated symptoms are limited. The aim of this study was to determine the endometriosis-associated symptoms and diagnosis-delay through an online survey. Methods: A cross-sectional study was conducted in Australia using an online web-based survey. All data were entered and analyzed using STATA (version 14/1). A total of 903 responders completed an online survey from September 2013 to October 2015.Results: Total participants of 903, 71.10% Australians (were born in Australia) and 28.90% Non-Australian (were not born in Australia), with self-reported diagnosis of endometriosis was confirmed by surgery in 86.5% of participants completed the online survey. Delay in diagnosis was 8.1±6.2 years. There was no difference between age range (p = 0.35), mean age of onset of the first symptoms (p = 0.93), and delay in diagnosis (p = 0.11) in both groups. Most common endometriosis-related symptoms that all responders had experienced in their lifetime were period pain 98.11%, fatigue 94.01%, bloating 90.69%, ovulation pain 88.70%, pelvic pain 87.26%, pain during before/after sexual activity 82.72% and heavy bleeding 82.17% and delayed fertility 37.98%. Treatments used in affected women included: pain killers 96.01% (n=867), hormonal medication 84.71% and surgical treatments 84.49 %. Rate of miscarriage or stillbirth was 13.4% and hysterectomy because of endometriosis was 9.6%. Conclusions: Vast similarities in demographics and endometriosis-associated symptoms among the Australian and non-Australian women with endometriosis support the universality of the disease characteristics. Delay in diagnosis of endometriosis is a problem and the reasons for delayed diagnosis must be better understood to try to shorten this delay. Except for pain, endometriosis patients suffer from a variety of symptoms and treatment must take into account the most prominent symptoms.