bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term cognitive fatigue effect on auditory temporal order judgments
Authors: Simon Júlia , Takács Endre , Orosz Gábor , Berki Borbála , Winkler István 
Published: January 2020

AbstractFatigue is a core symptom in many psychological disorders and it can strongly influence everyday productivity. As fatigue effects have been typically demonstrated after long hours of time on task, it was surprising that in a previous study, we accidentally found a decline of temporal order judgment (TOJ) performance within 5–8 min. After replicating prior relevant findings we tested whether pauses and/or feedback relating the participant’s performance to some “standard” can eliminate or reduce this short-term performance decline. We also assessed whether the performance decline is specific to the processes evoked by the TOJ task or it is a product of either general inattentiveness or the lack of willingness to thoroughly follow the task instructions. We found that both feedback and introducing pauses between successive measurements can largely reduce the performance decline, and that these two manipulations likely mobilize overlapping capacities. Performance decline was not present in a similar task when controlling for the TOJ threshold and it was not a result of uncooperative behavior. Therefore, we conclude that the TOJ threshold decline is either specific to temporal processing in general or to the TOJ task employed in the study. Overall, the results are compatible with the notion that the decline of TOJ threshold with repeated measures represents a short-term cognitive fatigue effect. This objective fatigue measure did not correlate with subjective fatigue. The latter was rather related to perceived difficulty/effort, the reduction of positive affectivity, heightened sensitivity to criticism, and the best TOJ threshold.
Differences in medical treatment and clinical characteristics between men and women with heart failure – a single-centre multivariable analysis
Authors: Norberg Helena , Pranic Veronica , Bergdahl Ellinor , Lindmark Krister 
Published: January 2020

Abstract
Purpose
The aims of this study were to examine sex differences in a heart failure population with regards to treatment and patient characteristics and to investigate the impact of sex on achieved doses of heart failure medications.

Methods and results
A total of 1924 patients with heart failure in a regional hospital were analysed, 622 patients had ejection fraction ≤ 40% of which 30% were women. In patients with reduced ejection fraction, women were older (79 ± 11 vs. 74 ± 12 years, P < 0.001), had lower body weight (70 ± 17 vs. 86 ± 18 kg, P < 0.001), lower estimated glomerular filtration rate (eGFR) (49 ± 24 vs. 71 ± 30 ml/min, P < 0.001) and received lower doses of heart failure medications than men. Multivariable linear regression on patients with reduced ejection fraction showed that sex was not associated with achieved dose of any heart failure medication. For angiotensin-converting enzyme inhibitors and angiotensin receptor blockers associated factors were eGFR, systolic blood pressure, age, ejection fraction, and heart rate. For beta-blockers associated factors were body weight, atrial fibrillation and age. For mineralocorticoid receptor antagonists associated factors were eGFR, serum potassium, age, systolic blood pressure, ejection fraction and heart rate.

Conclusion
Women with heart failure and reduced ejection fraction were prescribed lower doses of heart failure medications, were older, had worse renal function, and lower body weight than men. Sex was not independently associated with achieved doses of heart failure medications, instead age, renal function and body weight explained the differences in treatment.
Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines
Authors: Yuan Hong , Li Pinghua , Bao Huifang , Sun Pu , Bai Xingwen , Bai Qifeng , Li Na , Ma Xueqing , Cao Yimei , Fu Yuanfang , Li Kun , Zhang Jing , Li Dong , Chen Yingli , Zhang Jie , Lu Zengjun , Liu Zaixin 
Published: January 2020

AbstractFoot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective antibody response. Thus, improving the acid stability of FMDV is required for the efficacy of vaccine preparations. According to the previous studies, a single substitution or double amino acid substitutions (VP1 N17D, VP2 H145Y, VP2 D86H, VP3 H142D, VP3 H142G, and VP1 N17D + VP2 H145Y) in the capsid were introduced into the full-length infectious clone of type O FMDV vaccine strain O/HN/CHN/93 to develop seed FMDV with improved acid stability. After the transfection into BSR/T7 cells of constructed plasmids, substitution VP1 N17D or VP2 D86H resulted in viable and genetically stable FMDVs, respectively. However, substitution VP2 H145Y or VP1 N17D + VP2 H145Y showed reverse mutation and additional mutations, and substitution VP3 H141G or VP3 H141D prevented viral viability. We found that substitution VP1 N17D or VP2 D86H could confer increased acid resistance, alkali stability, and thermostability on FMDV O/HN/CHN/93, whereas substitution VP1 N17D was observed to lead to a decreased replication ability in BHK-21 cells and mildly impaired virulence in suckling mice. In contrast, substitution VP2 D86H had no negative effect on viral infectivity. These results indicated that the mutant rD86H carrying substitution VP2 D86H firstly reported by us could be more adequate for the development of inactivated FMD vaccines with enhanced acid stability.
A Real‐World, Population‐Based Analysis of the Outcomes of Colorectal Cancer Patients with Isolated Synchronous Liver or Lung Metastases Treated with Metastasectomy
Authors: Oweira Hani , Mehrabi Arianeb , Reissfelder Christoph , Abdel‐Rahman Omar 
Published: January 2020

AbstractObjectiveTo assess the survival outcomes among a contemporary cohort of colorectal cancer patients with isolated synchronous liver or lung metastases treated with or without surgical resection of the metastases.MethodsSurveillance, epidemiology and end results database has been accessed and cases with isolated liver or lung metastases diagnosed 2010–2015 have been accessed. Kaplan–Meier survival estimates were used to compare overall survival among patients who had or had not undergone metastasectomy. Multivariable Cox regression analysis was then used to assess the impact of metastasectomy on colorectal cancer‐specific survival.ResultsA total of 16,372 patients with colorectal cancer with isolated liver or lung metastases (M1a disease) were included in the current analysis (including 14,832 patients with isolated liver metastases and 1540 patients with isolated lung metastases). Patients who had undergone surgical resection of liver metastases have better overall survival compared to patients who had not undergone surgical resection of liver metastases (median overall survival: 38.0 months vs. 13.0 months; P < 0.001). Likewise, patients who had undergone surgical resection of lung metastases have better overall survival compared to patients who had not undergone surgical resection of lung metastases (median overall survival: 45.0 months vs. 19.0 months; P < 0.001). In a multivariable Cox regression analysis and among patients with isolated liver metastases, surgery to the metastases was associated with a reduced hazard of death (hazard ratio (HR) 0.567; 95% CI 0.529–0.609; P < 0.001). Likewise, and among patients with isolated lung metastases, surgery to the metastases was associated with a reduced hazard of death (HR 0.482; 95% CI 0.349–0.665; P < 0.001).ConclusionIn a contemporary cohort, metastasectomy seems to be associated with improvement in overall and cancer‐specific survival among patients with isolated synchronous liver or lung metastases from colorectal cancer. Whether this survival difference is totally ascribed to the effect of metastasectomy or it is the fact that patients who were eligible for surgical resection have limited disease extent and better medical profile (thus, leading to better survival) is unclear from such a population‐based study.
Experimental investigation of a single-degree-of-freedom system with Coulomb friction
Authors: Marino Luca , Cicirello Alice 
Published: January 2020

AbstractThis paper presents an experimental investigation of the dynamic behaviour of a single-degree-of-freedom (SDoF) system with a metal-to-metal contact under harmonic base or joined base-wall excitation. The experimental results are compared with those yielded by mathematical models based on a SDoF system with Coulomb damping. While previous experiments on friction-damped systems focused on the characterisation of the friction force, the proposed approach investigates the steady response of a SDoF system when different exciting frequencies and friction forces are applied. The experimental set-up consists of a single-storey building, where harmonic excitation is imposed on a base plate and a friction contact is achieved between a steel top plate and a brass disc. The experimental results are expressed in terms of displacement transmissibility, phase angle and top plate motion in the time and frequency domains. Both continuous and stick-slip motions are investigated. The main results achieved in this paper are: (1) the development of an experimental set-up capable of reproducing friction damping effects on a harmonically excited SDoF system; (2) the validation of the analytical model introduced by Marino et al. (Nonlinear Dyn, 2019.https://doi.org/10.1007/s11071-019-04983-x) and, particularly, the inversion of the transmissibility curves in the joined base-wall motion case; (3) the systematic observation of stick-slip phenomena and their validation with numerical results.
Evolution of quality culture in an HEI: critical insights from university staff in Bangladesh
Authors: Rahnuma Naureen 
Published: January 2020

AbstractThis paper evaluates experiences of quality culture as actualized by academic and administrative leaders in a nonprofit, private Bangladeshi university, ensuing the recent implementation of a state-stipulated national quality framework. Based on the data derived from ten interviews integrated with the Quality Assurance Framework document objectives, the purpose of this paper is to gain critical insight on what is working and what might need changing or developing in the future to support quality culture at higher education institutions. The article translates the key themes and elements of the evaluation process into a logic model to show the processes and structures through which the university can support the development of its internal quality culture. It offers a focused pathway for quality assurance activities, crucial in reinforcing and strengthening a culture of quality in Bangladeshi universities. As such, the paper seeks to make a contribution to Bangladesh’s higher education by providing a broad, evaluative insight into the preparedness and receptivity of the institutions to integrate sustainability into their teaching and learning as guided by the new quality assurance framework, mindful of the imperatives for quality assurance and enhancement coming mainly from the Western perspective, hence placing its development in the regional, and then global, context.
Vocabulary, metacognitive knowledge and task orientation as predictors of narrative picture book comprehension: from preschool to grade 3
Authors: Lepola Janne , Kajamies Anu , Laakkonen Eero , Niemi Pekka 
Published: January 2020

AbstractThis is a study of early picture book comprehension, its determinants and later development through primary school. More specifically, picture book comprehension was analyzed longitudinally from age 5 to age 9, delineating the unique contributions of vocabulary, metacognitive knowledge and task orientation to the initial level as well as to the growth of comprehension. A total of 90 Finnish-speaking children participated in the study. The children’s narrative picture book comprehension was assessed at age 5, age 6 and age 9. Vocabulary, metacognitive knowledge and task orientation were evaluated at age 5. Latent growth curve modeling showed a pattern of decreasing achievement gaps in narrative picture book comprehension. Vocabulary and metacognitive knowledge uniquely contributed to the concurrent level of narrative picture book comprehension. The results further showed that metacognitive knowledge and task orientation were positive and statistically significant predictors of the growth of picture book comprehension over and above the initial level of narrative picture book comprehension. These findings add to our knowledge about the development of inter-individual differences in narrative picture book comprehension and the roles of vocabulary, metacognitive knowledge and task orientation in it. They also suggest a novel way to assess the narrative comprehension potential among students with compromised working memory or decoding ability.
Analysis of surface runoff potential in ungauged basin using basin parameters and SCS-CN method
Authors: Nageswara Rao K. 
Published: January 2020

AbstractThe present research work was carried out to understand the influence of basin morphometric parameters on runoff potential in an ungauged basin using satellite images, topographical maps, and rainfall data combined with geospatial techniques. The upper Gosthani river basin is an ungauged basin which is located in the Eastern Ghats of Visakhapatnam District, Andhra Pradesh State, Southern India. The river Gosthani and its tributaries are draining through the basin area covering about 321.1 km2. The quantitative analysis of basin morphometry reveals that the area is under influenced by steep ground slopes, with moderate to less permeable rocks, leading to high runoff. The basin is elongated in shape resulting to flatter peak of flow for longer duration. The daily rainfall data during 2008–2016 were used in the estimation of runoff potential with the help of the Soil Conservation Service-Curve Number (SCS-CN) model. The weighted curve number was determined by the integration of land use and land cover, antecedent moisture condition, and hydrological soil groups. It was observed from the analysis that the overall increase in runoff corresponding to the rainfall. The area receives a good amount of rainfall, but most of it lost as surface runoff (nearly 40% of total rainfall) due to rapid overland flow and impermeable rocks. Analysis of morphometric parameters combined with SCS-CN-based approaches can be explored as an alternative for simulating the hydrological response of the basins.
An order approach to SPDEs with antimonotone terms
Authors: Scarpa Luca , Stefanelli Ulisse 
Published: January 2020

AbstractWe consider a class of parabolic stochastic partial differential equations featuring an antimonotone nonlinearity. The existence of unique maximal and minimal variational solutions is proved via a fixed-point argument for nondecreasing mappings in ordered spaces. This relies on the validity of a comparison principle.
On the stochastic nonlinear Schrödinger equations at critical regularities
Authors: Oh Tadahiro , Okamoto Mamoru 
Published: January 2020

AbstractWe consider the Cauchy problem for the defocusing stochastic nonlinear Schrödinger equations (SNLS) with an additive noise in the mass-critical and energy-critical settings. By adapting the probabilistic perturbation argument employed in the context of the random data Cauchy theory by Bényi et al. (Trans Am Math Soc Ser B 2:1–50, 2015) to the current stochastic PDE setting, we present a concise argument to establish global well-posedness of the mass-critical and energy-critical SNLS.
CIRCexplorer3: A CLEAR Pipeline for Direct Comparison of Circular and Linear RNA Expression
Authors: Ma Xu-Kai , Wang Meng-Ran , Liu Chu-Xiao , Dong Rui , Carmichael Gordon G. , Chen Ling-Ling , Yang Li 
Published: January 2020

Abstract
Sequences of circular RNAs (circRNAs) produced from back-splicing of exon(s) completely overlap with those from cognate linear RNAs transcribed from the same gene loci with the exception of their back-splicing junction (BSJ) sites. Therefore, examination of global circRNA expression from RNA-seq datasets generally relies on the detection of RNA-seq fragments spanning BSJ sites, which is different from the quantification of linear RNA expression by normalized RNA-seq fragments mapped to whole gene bodies. Thus, direct comparison of circular and linear RNA expression from the same gene loci in a genome-wide manner has remained challenging. Here, we update the previously-reported CIRCexplorer pipeline to version 3 for circular and linear RNA expression analysis from ribosomal-RNA depleted RNA-seq (CIRCexplorer3-CLEAR). A new quantitation parameter, fragments per billion mapped bases (FPB), is applied to evaluate circular and linear RNA expression individually by fragments mapped to circRNA-specific BSJ sites or to linear RNA-specific splicing junction (SJ) sites. Comparison of circular and linear RNA expression levels is directly achieved by dividing FPBcirc by FPBlinear to generate a CIRCscore, which indicates the relative circRNA expression level using linear RNA expression level as the background. Highly-expressed circRNAs with low cognate linear RNA expression background can be readily identified by CIRCexplorer3-CLEAR for further investigation. CIRCexplorer3-CLEAR is publically available at https://github.com/YangLab/CLEAR.
Length of stay, cost, and mortality of healthcare-acquired bloodstream infections in children and neonates: A systematic review and meta-analysis
Authors: Karagiannidou Sofia , Triantafyllou Christos , Zaoutis Theoklis E. , Papaevangelou Vassiliki , Maniadakis Nikolaos , Kourlaba Georgia 
Published: January 2020

AbstractObjective:To estimate the attributable mortality, length of stay (LOS), and healthcare cost of pediatric and neonatal healthcare-acquired bloodstream infections (HA-BSIs).Design:A systematic review and meta-analysis.Methods:A systematic search (January 2000–September 2018) was conducted in PubMed, Cochrane, and CINAHL databases. Reference lists of selected articles were screened to identify additional studies. Case–control or cohort studies were eligible for inclusion when full text was available in English and data for at least 1 of the following criteria were provided: attributable or excess LOS, healthcare cost, or mortality rate due to HA-BSI. Study quality was evaluated using the Critical Appraisal Skills Programme Tool (CASP). Study selection and quality assessment were conducted by 2 independent researchers, and a third researcher was consulted to resolve any disagreements. Fixed- or random-effect models, as appropriate, were used to synthesize data. Heterogeneity and publication bias were evaluated.Results:In total, 21 studies were included in the systematic review and 13 studies were included in the meta-analysis. Attributable mean LOS ranged between 4 and 27.8 days; healthcare cost ranged between $1,642.16 and $160,804 (2019 USD) per patient with HA-BSI; and mortality rate ranged between 1.43% and 24%. The pooled mean attributable hospital LOS was 16.91 days (95% confidence interval [CI], 13.70–20.11) and the pooled attributable mortality rate was 8% (95% CI, 6–9). A meta-analysis was not conducted for cost due to lack of eligible studies.Conclusions:Pediatric HA-BSIs have a significant impact on mortality, LOS, and healthcare cost, further highlighting the need for implementation of HA-BSI prevention strategies.
Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients
Authors: Cederwall S. , Påhlman L. I. 
Published: January 2020

Abstract
Adenovirus (AdV) can cause severe respiratory infections in children and immunocompromised patients, but less is known about severe AdV pneumonia in immunocompetent adults. In this retrospective study, we compared respiratory tract infections and pneumonia caused by AdV in immunocompromised and immunocompetent adult patients regarding clinical presentation and severity of infection. The results show that AdV can cause severe infections in both immunocompetent and immunocompromised patients, and the clinical presentation and need for hospitalisation, mechanical ventilation and antiviral treatment were equal in both groups. No underlying risk factors for severe AdV infection in healthy individuals were identified.
Early experiences of insensitive caregiving and children's self-regulation: Vagal tone as a differential susceptibility factor
Authors: Skibo Michael A. , Sturge-Apple Melissa L. , Suor Jennifer H. 
Published: January 2020

AbstractA considerable body of research has linked parenting to the development of children's self-regulation. However, few studies have considered different domains of self-regulation, the effects of early caregiving behaviors, and whether or not parenting influences children equally. Towards this, the present investigation tested how early maternal insensitivity was associated with difficulties in children's effortful control in early childhood and their regulation of negative emotions during the early school years. Further, we tested whether children's resting vagal tone may operate as a susceptibility factor, consistent with differential susceptibility models. The sample included 220 pairs of mothers and their children who were assessed at 18 months, 3.5 years and 5 years of age. Laboratory visits consisted of observational paradigms and survey assessments. Early maternal insensitivity at 18 months of age forecasted difficulties with effortful control at age 3.5. Moreover, effortful control at age 3.5 was associated with greater anger, but not sadness, regulation at age 5. Consistent with differential susceptibility, children's resting vagal tone at 18 months of age moderated the role of early caregiving on children's effortful control. The findings suggest that low resting vagal tone may operate as a differential susceptibility factor in process models testing associations between early caregiving environments and children's self-regulation.
Surface Deformation and Influence of Hydrological Mass Over Himalaya and North India Revealed From a Decade of Continuous GPS and GRACE Observations
Authors: Saji Ajish P. , Sunil P. S. , Sreejith K. M. , Gautam Param K. , Kumar K. Vijay , Ponraj M. , Amirtharaj S. , Shaju Rose Mary , Begum S. K. , Reddy C. D. , Ramesh D. S. 
Published: January 2020

AbstractThe India‐Eurasia collision, driven by tectonic forcing, is modulated by nontectonic forcing allied to seasonal variations in the neighboring regions. To decipher the ground deformation in response to hydrological mass variations of the Himalaya and North India, we analyzed continuous Global Positioning System (cGPS) observations from 50 sites together with Gravity Recovery and Climate Experiment (GRACE) data for the period 2004–2015. Vertical components of surface deformation derived from GPS and GRACE show moderate to high‐level amplitude correlation with a slope value of 0.76 and a level of phase delay from ±25° to ±30°. The average weighted root‐mean‐square reduction (WRMS) of 17.72% suggests the prominence of hydrological mass variations particularly over the sub‐Himalaya and Indo‐Gangetic Plain (IGP). GPS‐derived vertical deformation after correcting the hydrological effects utilizing GRACE observations suggests that the sub‐Himalaya and IGP are undergoing subsidence and the surrounding areas show uplift. In addition to the tectonic and nontectonic forcings, an unsustainable consumption of groundwater associated to irrigation and other anthropogenic uses influence the subsidence rate in the IGP and sub‐Himalaya. Further, 2‐D elastic dislocation modeling suggests that GRACE correction to the GPS vertical velocity causes a reduction in the subsurface slip rate estimation over the Main Himalayan Thrust (MHT) system by 12.06% and improves the chi‐square misfit by 20.32%.