bluuebunny/crossref_metadata_2025_split huggingface dataset:
Globalizing HRD Academic Practice: Developing a Global Mindset for Teaching and Research
Authors: Cseh Maria , Crocco Oliver S. 
Published: March 2020

The Problem As a result of the domination of U.S.- and U.K.-centric approaches to human resource development (HRD), current academic practices often reside in ethnocentric content-related silos, which include certain theoretical frameworks, models, mindsets, and ways of conceptualizing. Given the exponential increase in globalization and the complex global issues facing the field of HRD, these teaching and research practices as well as the limited HRD global and transdisciplinary networks cannot offer the needed solutions to the problems faced by professionals around the world in their workplaces, communities, and societies. The Solution To understand this problem empirically and recommend solutions based on our findings, we reviewed journal articles published in the last year in our four Academy of Human Resource Development (AHRD)-sponsored journals and HRD programs of universities that are members of AHRD’s Program Excellence Network (PEN) and University Forum for Human Resource Development (UFHRD) to understand the state of globalization of HRD research and teaching. We offer recommendations for HRD scholars representing the new guard to globalize their teaching and research and professional associations to guide and support the globalization of HRD academic practice. The Stakeholders This article is of particular interest to HRD scholars in all stages of their careers seeking to globalize their academic practice and contribute to their own and their learners’ global mindset development and to professional associations guiding and supporting the globalization of HRD academic practice.
The structural validity of the Finnish version of the Disabilities of the Arm, Shoulder and Hand: A Rasch model analysis
Authors: Ikonen J , Hulkkonen S , Ryhänen J , Häkkinen A , Karppinen J , Repo JP 
Published: March 2020

Introduction The construct validity of the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH) has previously been questioned. The purpose of this study was to evaluate the measurement properties of the Finnish version of the DASH for assessing disability in patients with hand complaints using Rasch Measurement Theory. Methods A cohort of 193 patients with typical hand and wrist complaints were recruited at a surgery outpatient clinic. The DASH scores were analysed using the Rasch model for differential item functioning, unidimensionality, fit statistics, item residual correlation, coverage/targeting and reliability. Results In the original DASH questionnaire, the item response thresholds were disordered for 2 of 30 of the items. The item fit was poor for 9 of 30 of the items. Unidimensionality was not supported. There was substantial residual correlation between 87 pairs of items. Item reduction (chi square 95, degrees of freedom 50, p < 0.001) and constructing two testlets led to unidimensionality (chi square 0.64, degrees of freedom 4, p = 0.96). Person separation index was 0.95. The testlets had good fit with no differential item functioning towards age or gender. Conclusion Unidimensionality of the original Finnish version of the DASH was not supported, meaning the questionnaire seems to gauge traits other than disability alone. Hence, the clinician must be careful when trying to measure change in patients’ scores. Item reduction or the creation of testlets did not lead to good alternatives for the original Finnish DASH. Differential item functioning showed that the original Finnish scale exhibits minor response bias by age in one item. The original Finnish DASH covers different levels of ability well among typical hand surgery patients.
Choosing the Distal Fusion Levels in Lenke Type 1 Adolescent Idiopathic Scoliosis: How Do the Existing Classifications and Recommendations Guide Us?
Authors: Garg Bhavuk , Mehta Nishank , Mukherjee Rudra Narayan 
Published: March 2020

Study Design: Retrospective cohort. Objective: ( a) To compare the recommendations of Lenke and Peking Union Medical College (PUMC) classifications in choosing distal fusion levels in Lenke 1 adolescent idiopathic scoliosis (AIS) curves and ( b) to analyze whether the variability in distal fusion levels influences treatment outcomes. Methods: Hospital records of Lenke 1 AIS patients operated for single stage, posterior-only deformity correction were analyzed. Distal fusion levels recommended by Lenke and PUMC classifications were calculated and were compared with the actual distal fusion levels. The study population was divided based on whether the actual distal fusion levels were in agreement, shorter or longer than those recommended by Lenke classification. Subgroup analysis of Lenke 1C curves was done. The groups were compared with regard to the following outcome measures: Cobb angle correction, postoperative sagittal vertical axis, postoperative C7 offset, and Scoliosis Research Society–22r (SRS-22r) score at 24 months. Results: The distal fusion levels recommended by the 2 classifications were in agreement in 92 of 104 cases. In all the cases with disparity, Lenke classification recommended shorter fusions than the PUMC classification. No statistically significant difference was observed in the outcome measures—whether the actual distal fusion levels were in agreement, shorter, or longer than those recommended by the Lenke classification or whether or not the recommendations for selective fusion of any of these classifications were adhered to. Conclusion: Lenke classification can save fusion levels without compromising on treatment outcomes when compared with PUMC classification. Variability in choice of distal fusion levels is not clinically significant at 24-month follow-up.
Total knee replacement with and without emicizumab: a unique comparison of perioperative management
Authors: Evans Matthew S. , Davis Charles , Eyster M. Elaine 
Published: March 2020

Key Points
Prophylaxis with emicizumab was used in a patient with severe hemophilia with an inhibitor who underwent knee surgery. Use of emicizumab during surgery led to less recombinant factor VIIa and less bleeding, in addition to cost savings, for this patient.
XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma
Authors: Wang Yuhui , Sun Dahong , Sheng Ying , Guo Hong , Meng Fanchun , Song Tingting 
Published: March 2020

Abstract
Background
Retinoblastoma (RB) is the most common intraocular malignancy in children. Long non-coding RNA X-inactive specific transcript (lncRNA XIST) has been reported to be associated with RB, but research on the mechanism of XIST is not well studied.

Methods
Expressions of XIST, microRNA-140-5p (miR-140-5p), and sex-determining region Y-related high-mobility group box 4 (SOX4) were analyzed by qRT-PCR or Western blot. Relationships of XIST, SOX4, and miR-140-5p were evaluated by dual-luciferase reporter assay and Spearman’s analysis. Cell Counting Kit-8 (CCK-8) and Transwell assay were performed to assess the function of XIST on RB cell proliferation and invasion.

Results
In RB tissues, XIST and SOX4 expressions were obviously increased, but the miR-140-5p expression was markedly reduced. XIST expression was positively related to SOX4 expression while negatively correlated with miR-140-5p expression, and negative correlation was exhibited between miR-140-5p and SOX4 expression in RB tissues. XIST was confirmed to directly bind to miR-140-5p, and SOX4 was one target of miR-140-5p. XIST knockdown could impede RB cell proliferation and invasion, while miR-140-5p inhibition reversed the effects. In addition, XIST overexpression or miR-140-5p inhibition could abrogate the inhibition of SOX4 silencing on cell proliferation and invasion of RB cells.

Conclusions
XIST was obviously increased in RB tissues and cells, and XIST inhibition repressed the proliferation and invasion of RB cells by miR-140-5p/SOX4 axis, which may provide new understandings of the XIST molecular mechanism in RB.
Fibromatosis-like metaplastic carcinoma: a case report and review of the literature
Authors: Victoor Jasper , Bourgain Claire , Vander Borght Sara , Vanden Bempt Isabelle , De Rop Carine , Floris Giuseppe 
Published: March 2020

Abstract
Background
We report an unusual case of low-grade fibromatosis-like metaplastic carcinoma (LG-FLMC) of the breast. This exceedingly rare epithelial breast malignancy has been reported only 68 times in the past 20 years, and is classified as a subtype of metaplastic breast carcinoma (MBC). It is a locally aggressive tumor with a low potential for lymph node and distant metastases, but with a tendency to recur after excision. Here we describe a less common presentation of LG-FLMC, provide its molecular characterization, discuss the major differential diagnosis and bring a short review of the literature.

Case presentation
A 65-year-old woman presented with a self-palpated breast lump that had discordant radio-pathological features. While imaging results were compatible with an infiltrative malignancy, on core needle biopsy (CNB) a sharply delineated lesion composed by a bland-looking population of spindle cells was observed; excision was recommended for final diagnosis. Histology of the resection specimen showed small areas of epithelial differentiation and foci of peripheral invasion. Immunohistochemical analysis revealed a co-immunoreactivity for epithelial and myoepithelial markers in the spindle cell component. Mutation analysis with a capture-based next generation sequencing method revealed pathogenic mutations in GNAS, TERT-promotor and PIK3R1 genes. A diagnosis of LG-FLMC was rendered.

Conclusion
This case highlights the importance of a broad differential diagnosis, exhaustive sampling and the use of a broad immunohistochemical panel whenever dealing with a low-grade spindle cell lesion in the breast, and provides further insights into the molecular background of LG-FLMC.
The impact of socio-demographic features on anxiety and depression amongst navy veterans after retirement: a cross-sectional study
Authors: Georgantas Dimitris , Tsounis Andreas , Vidakis Ioannis , Malliarou Maria , Sarafis Pavlos 
Published: March 2020

AbstractObjectiveRetirement from work may trigger various changes in everyday life that affect mental health. The current cross-sectional study, conducted with 231 veterans, examines the relationship between socio-demographic features and both anxiety and depression in navy veterans after retirement. Spielberg’s State-Trait Anxiety Inventory (STAI) was used for anxiety assessment, and the Beck Depression Inventory (BDI) was used for depression assessment. The analysis was performed with the Statistical Package for Social Sciences (SPSS), version 20.0.ResultsIt was found that the mean score of state anxiety was 41 and trait anxiety, 38. Severe depression was found in 6.5% of the veterans, moderate in 8.3% and mild in 21.7%. The presence of a serious health problems was an independent predictor of both anxiety and depression’s more serious symptoms. Inversely, the stability in terms of retirement choice was negatively related to depression, while the development of new interests and activities after retirement was negatively related to both anxiety and depression. Further, life satisfaction after retirement was a predictor of lower current anxiety levels among veterans.
Antimicrobial use and resistance in food-producing animals and the environment: an African perspective
Authors: Kimera Zuhura I. , Mshana Stephen E. , Rweyemamu Mark M. , Mboera Leonard E. G. , Matee Mecky I. N. 
Published: March 2020

Abstract
Background
The overuse of antimicrobials in food animals and the subsequent contamination of the environment have been associated with development and spread of antimicrobial resistance. This review presents information on antimicrobial use, resistance and status of surveillance systems in food animals and the environment in Africa.

Methods
Information was searched through PubMed, Google Scholar, Web of Science, and African Journal Online databases. Full-length original research and review articles on antimicrobial use, prevalence of AMR from Africa covering a period from 2005 to 2018 were examined. The articles were scrutinized to extract information on the antimicrobial use, resistance and surveillance systems.

Results
A total of 200 articles were recovered. Of these, 176 studies were included in the review while 24 articles were excluded because they were not relevant to antimicrobial use and/or resistance in food animals and the environment. The percentage of farms using antimicrobials in animal production ranged from 77.6% in Nigeria to 100% in Tanzania, Cameroon, Zambia, Ghana and Egypt. The most antibiotics used were tetracycline, aminoglycoside and penicillin groups. The percentage of multi drug resistant isolates ranged from 20% in Nigeria to 100% in South Africa, Zimbabwe and Tunisia. In the environment, percentage of multi drug resistant isolates ranged from 33.3% in South Africa to 100% in Algeria. None of the countries documented national antimicrobial use and resistance surveillance system in animals.

Conclusion
There is high level of antimicrobial use, especially tetracycline, aminoglycoside and penicillin in animal production systems in Africa. This is likely to escalate the already high prevalence of antimicrobial resistance and multi drug resistance in the continent. This, coupled with weak antimicrobial resistance surveillance systems in the region is a great concern to the animals, environment and humans as well.
Rhizosphere protists are key determinants of plant health
Authors: Xiong Wu , Song Yuqi , Yang Keming , Gu Yian , Wei Zhong , Kowalchuk George A. , Xu Yangchun , Jousset Alexandre , Shen Qirong , Geisen Stefan 
Published: March 2020

AbstractBackgroundPlant health is intimately influenced by the rhizosphere microbiome, a complex assembly of organisms that changes markedly across plant growth. However, most rhizosphere microbiome research has focused on fractions of this microbiome, particularly bacteria and fungi. It remains unknown how other microbial components, especially key microbiome predators—protists—are linked to plant health. Here, we investigated the holistic rhizosphere microbiome including bacteria, microbial eukaryotes (fungi and protists), as well as functional microbial metabolism genes. We investigated these communities and functional genes throughout the growth of tomato plants that either developed disease symptoms or remained healthy under field conditions.ResultsWe found that pathogen dynamics across plant growth is best predicted by protists. More specifically, communities of microbial-feeding phagotrophic protists differed between later healthy and diseased plants at plant establishment. The relative abundance of these phagotrophs negatively correlated with pathogen abundance across plant growth, suggesting that predator-prey interactions influence pathogen performance. Furthermore, phagotrophic protists likely shifted bacterial functioning by enhancing pathogen-suppressing secondary metabolite genes involved in mitigating pathogen success.ConclusionsWe illustrate the importance of protists as top-down controllers of microbiome functioning linked to plant health. We propose that a holistic microbiome perspective, including bacteria and protists, provides the optimal next step in predicting plant performance.
Ultrathin MEMS thermoelectric generator with Bi2Te3/(Pt, Au) multilayers and Sb2Te3 legs
Authors: Liu Yang , Mu Erzhen , Wu Zhenhua , Che Zhanxun , Sun Fangyuan , Fu Xuecheng , Wang Fengdan , Wang Xinwei , Hu Zhiyu 
Published: March 2020

AbstractMultilayer structure is one of the research focuses of thermoelectric (TE) material in recent years. In this work, n-type 800 nm Bi2Te3/(Pt, Au) multilayers are designed with p-type Sb2Te3 legs to fabricate ultrathin microelectromechanical systems (MEMS) TE devices. The power factor of the annealed Bi2Te3/Pt multilayer reaches 46.5 μW cm−1 K−2 at 303 K, which corresponds to more than a 350% enhancement when compared to pristine Bi2Te3. The annealed Bi2Te3/Au multilayers have a lower power factor than pristine Bi2Te3. The power of the device with Sb2Te3 and Bi2Te3/Pt multilayers measures 20.9 nW at 463 K and the calculated maximum output power reaches 10.5 nW, which is 39.5% higher than the device based on Sb2Te3 and Bi2Te3, and 96.7% higher than the Sb2Te3 and Bi2Te3/Au multilayers one. This work can provide an opportunity to improve TE properties by using multilayer structures and novel ultrathin MEMS TE devices in a wide variety of applications.
Rubber artificial skin layer with flexible structure for shape estimation of micro-undulation surfaces
Authors: Ando Mitsuhito , Takei Toshinobu , Mochiyama Hiromi 
Published: March 2020

AbstractIn this paper, we propose a wearable tactile sensor for measuring the shape of micro-undulations on a hard surface. The proposed sensor has two layers. The inner one is a thin rubber layer into which a strain gauge is embedded that is formed around a user’s finger. The outer layer is a flexible structure that consists of numerous pins on a flexible sheet. The shape of micro-undulations on an object surface can be measured when a user wearing the sensor traces the surface. The results of an experiment, in which we compare the cases with and without the flexible structure of the sensor, show that our proposed sensor is sufficiently accurate to measure the shape of micro-undulations due to its flexible structure, which contributes significantly to improving its signal-to-noise ratio.
Changes in higher order aberrations after central corneal regularization - a comparative two-year analysis of a semi-automated topography-guided photorefractive keratectomy combined with corneal cross-linking
Authors: Iselin Katja C. , Baenninger Philipp B. , Bachmann Lucas M. , Bochmann Frank , Thiel Michael A. , Kaufmann Claude 
Published: March 2020

AbstractBackgroundThe optical quality in progressive keratoconus deteriorates due to ectasia and distortion of the corneal shape and optics. While corneal cross-linking (CXL) aims at stopping disease progression, “CXL-Plus” combines CXL with excimer laser ablation to improve visual function. Central Corneal Regularization (CCR) represents a therapeutic excimer laser modality specifically designed to smoothen the ectatic corneal shape and to reduce higher order aberrations (HOA). We set out to compare CXL-Plus, consisting of CXL combined with CCR, with CXL by itself for patients with progressive keratoconus.MethodsRetrospective 2-year matched group analysis of patients who either underwent CXL-Plus (n = 28) or CXL as a sole procedure (n = 28) for progressive keratoconus. Main outcome parameters were HOA, visual function and tomographic results 12 and 24 months postoperatively.ResultsAfter 12 months, the total HOA root mean square wavefront error was reduced from 0.79 ± 0.30 to 0.40 ± 0.19 μm (CXL-Plus;p <  0.0001) and changed from 0.71 ± 0.28 to 0.73 ± 0.36 μm (CXL;p = 0.814). Uncorrected distance visual acuity improved from 0.70 ± 0.35 to 0.36 ± 0.29 logMAR (CXL-Plus;p = 0.0002) and from 0.65 ± 0.39 to 0.46 ± 0.37 logMAR (CXL;p = 0.067), translating to gains of three or more lines in 50% (CXL-Plus) and 36% (CXL) of patients. The steepest keratometry value (Kmax) regressed by 5.84 D (CXL-Plus;p <  0.0001) and 0.66 D (CXL;p = 0.752). For none of the investigated parameters a statistically significant change could be shown between 12 and 24 months.ConclusionsCXL-Plus in the form of a CCR reduces HOA and Kmax more effectively than CXL as a sole procedure.
Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study
Authors: Chanteloup Gaétan , Cordonnier Marine , Isambert Nicolas , Bertaut Aurélie , Marcion Guillaume , Garrido Carmen , Gobbo Jessica 
Published: March 2020

Abstract
Background
Cancer is the second leading cause of death globally. Early detection and disease management lead to a better survival rate. Consequently, discovery of novel methods in cancer early diagnosis is a field of active research. Minimally invasive liquid biopsies are generating growing interest. Circulating tumour cells (CTCs) have been identified in patients’ blood; nevertheless, these cells are rare and heterogeneous. Exosomes are extracellular nanovesicles released into the extracellular environment via the endosomal vesicle pathway and found in different body fluids. Exosomes deliver bioactive cargo such as proteins, mRNA and miRNA to recipient cells in the tumour environment. We have recently shown that heat shock protein 70 (HSP70) is detected in the membrane of tumour-derived exosomes, in contrast to normal cells. One single cancer cell can release thousands of HSP70-exosomes, facilitating detection. The aim of the pilot study ExoDiag is to determine whether it is possible to detect and quantify HSP70-exosomes in blood in patients with solid cancers.

Methods
Bicentric pilot study that will include 60 adult patients with metastatic and non-metastatic solid tumours and 20 healthy volunteers. Exosomes will be isolated from blood and urine samples, and HSP70 concentration will be determined. Patients will be followed for 1 year. The study is sponsored by Georges-François Leclerc Centre and is currently ongoing.

Discussion
We expect to demonstrate that HSP70-exosomes could be a powerful tool to diagnose cancer and to guide clinicians in therapeutic decision-making, improving patient’s care.

Trial Registration
ClinicalTrials.gov identifier NCT02662621. Registered 20 January 2016, https://clinicaltrials.gov/ct2/show/study/NCT02662621?term=NCT02662621&rank=1
Prostitution in northern Central India: an ethnographical study of Bedia community
Authors: Rana Usha , Sharma Diwakar , Ghosh Debarati 
Published: March 2020

AbstractBedia community has been engaged in singing and dancing as ‘rai’ folk artists during the rule of monarchy in central India. It is mentioned in colonial literature that Bedia were a nomadic tribe and often engaged in criminal activities too. After the end of monarchy and change in the laws of the state, Bedias had nothing left for their survival. Therefore, Bedia women engaged in prostitution. Prostitution gradually became their primary source of livelihood. They trained their daughters to become prostitutes in the future. Girls were introduced into this profession as soon as they reached puberty. These girls worked at dance bars and also as professional sex workers in metro cities and villages. Their fathers and brothers worked as pimps/agents for the girls and their clients. Their families survived on the female’s earnings. Bedia community inhabits many villages of Madhya Pradesh and central India. Since these villages are close to the city, customers find it easy to visit prostitutes regularly, and occasionally prostitutes also visit a customer on demand. Bedia women have been vulnerable victims of their community’s traditional and cultural practices. Prostitution has a social stigma and is seen as immoral by other communities. Thus, Bedias are never accepted by other communities due to their disreputable professional practices. This paper deals with the historical understanding of the Bedia as sex workers and the contemporary situation of a particular community. The data was collected through ethnographic fieldwork from two villages (Habla and Fatehpur) and secondary sources. In particular, we shall discuss the socio-cultural aspects, family and kinship, lifestyle, the status of women, and domination of culture in this paper.