bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement-driven AA-CAES Model for Distribution Network Dispatch in Coordination with Renewable Generation
Authors: Xie Yuguang , Bai Jiayu , Liu Dangwu , Zheng Tianwen , Mei Shengwei 
Published: July 2020

Abstract
Advanced adiabatic compressed air energy storage (AA-CAES) could play an important role in power distribution system for mitigating the intermittency of distributed renewable generations and reducing the peak-valley difference of load demand, which requires to operate AA-CAES under off-design conditions. A power system dispatch oriented AA-CAES model was proposed based on the technically thermodynamic performance curves of compressor and expansion calibrated from experiments, highlighting the impact of AA-CAES part-lard features on charging/discharging efficiency and capacity. The proposed model is integrated with economic dispatch problem of power distribution systems, giving rise to a nonlinear program due to the state-dependent charging and discharging performances. The dispatch model is further linearized via piecewise linear approximation and special-ordered set of type 2, and its equivalent mixed integer linear formulation is presented. A modified IEEE 33-bus system is adopted to verify the effectiveness of proposed model for renewables accommodation.
Analysis and model development of hybrid power control strategy
Authors: Tian Yang , Gang Han , Yanxin Nie , Peiliang Yu , Linbo Wang 
Published: July 2020

Abstract
Plug-in hybrid electric vehicle, as a part of new energy vehicle, plays an important role in energy saving and emission reduction. Taking one Plug-in Hybrid Power System as a sample, this paper first analyses the vehicle control strategy through experiments, including mode switching conditions, energy management strategy and other control strategies; and then builds the vehicle control strategy model to simulate the relevant economic indicators using Simulink according to vehicle benchmark strategy. Finally, the simulation results are compared with the experimental results, which further verifies the correctness of the vehicle control strategy and model, realize the model development of competitive car. The development of competitive vehicle model not only has the reference value of vehicle key control strategy, but also can study and analysis the influence of these parameters on vehicle dynamic and economy by modifying the component parameters or key control parameters in the simulation model, so as to provide the direction for the development of new vehicles.
Analysis and Quantification of the Impact of Energy Storage on Wind Power Utilization
Authors: Fang Baomin , Cao Yang , Wei Wei , Huang Shaowei , Mei Shengwei 
Published: July 2020

Abstract
Energy storage plays a significant role in accommodating the rapidly increasing wind power in power system, and its two important parameters, maximum charging/discharging power and total capacity, have important impacts on wind power utilization. In this paper, we propose two characterization models to quantify the relationship between wind power curtailment rate and energy storage parameters, in the sense of expectation and robustness for wind uncertainty. By adopting typical wind power scenarios and duality theory, the original characterization models are reformulated into a series of linear programs with different parameter sets for efficient solving. Case studies demonstrate the effectiveness of the proposed models and methods.
Comparative study of seismic and non-seismic analysis of a soil slope to develop correlations for factor of safety considering horizontal and vertical seismic coefficients
Authors: Israr Khan Muhammad , Wang Shuhong 
Published: July 2020

Abstract
Seismic and non-seismic analysis of any engineering project always gives different results. A soil slope is analysed in this research and both seismic and non-seismic analysis is performed to know about the difference in the factor of safety values. Correlations are developed between both these cases. These correlations are applicable for homogenous slopes only.
SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity
Authors: Phipps William S , SoRelle Jeffrey A , Li Quan-Zhen , Mahimainathan Lenin , Araj Ellen , Markantonis John , Lacelle Chantale , Balani Jyoti , Parikh Hiren , Solow E Blair , Karp David R , Sarode Ravi , Muthukumar Alagarraju 
Published: July 2020

Abstract

Objectives
Initial reports indicate adequate performance of some serology-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assays. However, additional studies are required to facilitate interpretation of results, including how antibody levels impact immunity and disease course.

Methods
A total of 967 subjects were tested for IgG antibodies reactive to SARS-CoV-2, including 172 suspected cases of SARS-CoV-2, 656 plasma samples from healthy donors, 49 sera from patients with rheumatic disease, and 90 specimens from individuals positive for polymerase chain reaction (PCR)–based respiratory viral panel. A subgroup of SARS-CoV-2 PCR-positive cases was tested for IgM antibodies by proteome array method.

Results
All specificity and cross-reactivity specimens were negative for SARS-CoV-2 IgG antibodies (0/795, 0%). Positive agreement of IgG with PCR was 83% of samples confirmed to be more than 14 days from symptom onset, with less than 100% sensitivity attributable to a case with severe immunosuppression. Virus-specific IgM was positive in a higher proportion of cases less than 3 days from symptom onset. No association was observed between mild and severe disease course with respect to IgG and IgM levels.

Conclusions
The studied SARS-CoV-2 IgG assay had 100% specificity and no adverse cross-reactivity. Measures of IgG and IgM antibodies did not predict disease severity in our patient population.
Effects of Question Type and Order When Measuring Peak Consumption of Risky Drinking Events
Authors: Yeung Jun-Ting , Livingston Michael , Callinan Sarah , Wright Cassandra , Kuntsche Emmanuel , Room Robin , Dietze Paul 
Published: July 2020

Abstract

Aims
There is new interest in measuring alcohol consumption during risky drinking events, but there is little guidance on how to best ask such questions. In this study, we contrast two different types of questions on peak consumption over a single heavy drinking occasion. We used a general question that ask respondents to recall the total amount consumed (total consumption question), and location-specific questions that ask respondents to recall consumption in each drinking location (location-specific peak consumption, LSPC).

Methods
Heavy drinkers (≥11 Australian Standard Drinks (ASD) per occasion for males, ≥8 for females) from the second wave of a prospective cohort study were recruited via landline random digit dial from Melbourne in 2012. Respondents were randomly assigned to surveys of different question order, and either first received total consumption (n = 127) or LSPC questions (n = 147). T-tests compared peak consumption between categories stratified by sex and consumption tercile.

Results
Mean peak consumption was 12.5 ASD. Irrespective of question order, consumption amounts for total consumption and LSPC questions were not significantly different for both sexes. However, drinkers in the highest tercile asked LSPC questions first provided significantly higher consumption estimates in response to the total consumption question than in response to the LSPC questions.

Conclusion
At a population level, LSPC and total consumption questions produce similar estimates of peak consumption for risky drinking events. Except for heavy drinkers, general consumption questions may be sufficient when asking about these drinking events in consumption surveys, without the greater response burden of longer LSPC questions.
Preliminary Outcomes of Hypochlorous Acid as an Adjunct for Pocket Irrigation in Revision Aesthetic Breast Surgery
Authors: Hasan Samir , Mujadzic Mirza , Kaswan Sumesh , Halpern Joshua , Van Natta Bruce , Lund Herluf 
Published: July 2020

Abstract

Background
Capsular contracture is a challenging problem for plastic surgeons despite advances in surgical technique. Breast pocket irrigation decreases bacterial bioburden. Studies have shown that hypochlorous acid (HOCl; PhaseOne Health, Nashville, TN) effectively penetrates and disrupts biofilms; however, there are limited clinical data regarding this irrigation in breast augmentation.

Objectives
The aim of this study was to investigate the effects of HOCl pocket irrigation in revision breast augmentation by evaluating rates of capsular contracture recurrence, infection, and allergic reactions.

Methods
We performed an institutional review board–approved retrospective chart review of revision breast augmentation cases for Baker grade III/IV capsular contractures in which pockets were irrigated with HOCl. Data were obtained from 3 board-certified plastic surgeons.

Results
The study included 135 breasts in 71 patients, who ranged in age from 27 to 77 years (mean, 53.7 years). Follow-up ranged from 12 to 41 months (mean, 20.2 months). Postoperatively, there were 2 unilateral Baker grade III/IV recurrences at 13 months and 1 bilateral Baker grade II recurrence at 3 months. There were no infections or allergic reactions. The overall Baker grade III/IV capsular contracture recurrence rate was 0% at 12 months and 1.5% at 15 months.

Conclusions
Breast pocket irrigation decreases bioburden, which may influence capsular contracture recurrence. We evaluated 3 varied applications of HOCl in revision aesthetic breast surgery and found a low capsular contracture recurrence rate and no adverse reactions. We plan to report our findings with HOCl in primary breast augmentation in the future, and other studies are being conducted on the efficacy of HOCl in aesthetic surgery.

Level of Evidence: 4
Bioinformatics toolbox for exploring protein phosphorylation network
Authors: Shi Xing-Xing , Wu Feng-Xu , Mei Long-Can , Wang Yu-Liang , Hao Ge-Fei , Yang Guang-Fu 
Published: July 2020

AbstractA clear systematic delineation of the interactions between phosphorylation sites on substrates and their effector kinases plays a fundamental role in revealing cellular activities, understanding signaling modulation mechanisms and proposing novel hypotheses. The emergence of bioinformatics tools contributes to studying phosphorylation network. Some of them feature the visualization of network, enabling more effective trace of the underlying biological problems in a clear and succinct way. In this review, we aimed to provide a toolbox for exploring phosphorylation network. We first systematically surveyed 19 tools that are available for exploring phosphorylation networks, and subsequently comparatively analyzed and summarized these tools to guide tool selection in terms of functionality, data sources, performance, network visualization and implementation, and finally briefly discussed the application cases of these tools. In different scenarios, the conclusion on the suitability of a tool for a specific user may vary. Nevertheless, easily accessible bioinformatics tools are proved to facilitate biological findings. Hopefully, this work might also assist non-specialists, students, as well as computational scientists who aim at developing novel tools in the field of phosphorylation modification.
Pharmacophore-driven identification of N-methyl-D-receptor antagonists as potent neuroprotective agents validated using in vivo studies
Authors: Sharma Mukta , Mittal Anupama , Singh Aarti , Jainarayanan Ashwin K , Sharma Swapnil , Paliwal Sarvesh 
Published: July 2020

AbstractAlzheimer’s disease (AD), apparently the most widespread reason behind dementia, is delineated by a continuous cognitive weakening in the aged. During its progression, N-methyl-D-aspartate receptor (NMDAR) antagonists are known to play a pivotal part in the mechanisms of learning and memory. Since there is an unmet medical need for the treatment of AD, we aim to identify possible chemical compounds targeted toward N-methyl-D-aspartate receptors. Three-dimensional models are developed to unveil some of the essential characteristics of the N-methyl-D-aspartate receptors by using a collection of already discovered N-methyl-D-aspartate receptor inhibitors. This is followed by virtual screening, which results in novel chemical compounds having the potential to inhibit N-methyl-D-aspartate receptors. Molecular docking studies and analysis promulgated two lead compounds with a high LibDock score. The compounds are shortlisted based on high estimated activity, fit values, LibDock score, no violation of Lipinski’s, and availability for procuring. Finally, the shortlisted compounds are tested by employing in vivo studies, which we further propose as potential NMDA inhibitors for treating AD.
Reading Fluency in Young Elementary School Age Deaf and Hard-of-Hearing Children
Authors: Easterbrooks Susan R , Lederberg Amy R 
Published: July 2020

Abstract
The Center on Literacy and Deafness examined the language and reading progress of 336 young deaf and hard-of-hearing children in kindergarten, first and second grades on a series of tests of language, reading, and spoken and fingerspelled phonological awareness in the fall and spring of the school year. Children were divided into groups based on their auditory access and classroom communication: a spoken-only group (n = 101), a sign-only group (n = 131), and a bimodal group (n = 104). Previous work reports the overall data (Antia, S., Lederberg, A., Schick, B., Branum-Martin, L., Connor, C. M., & Webb, M. (2020a). Language and reading progress of young DHH children. Journal of Deaf Studies and Deaf Education, (3), 25; Lederberg, A. R., Branum-Martin, L., Webb, M. L., Schick, B., Antia, S., Easterbrooks, S. R., & Connor, C. M. (2019). Modality and interrelations among language, reading, spoken phonological awareness, and fingerspelling. Journal of Deaf Studies and Deaf Education, 24(4), 408–423). This report presents an in-depth look at the reading fluency of the participants measured along multiple dimensions. In general, 43% of the participants were unable to read fluently and an additional 23% were unable to read fluently at grade level. Rate and accuracy, rate of growth, miscue analysis, and self-corrections differed by communication modality. Most notably, children demonstrated limited strategies for self-correction during reading fluency tasks.
The Effect of Diabetes on the Cognitive Trajectory of Older Adults in Mexico and the United States
Authors: Avila Jaqueline C , Mejia-Arangom Silvia , Jupiter Daniel , Downer Brian , Wong Rebeca 
Published: July 2020

Abstract

Objectives
To study the impact of diabetes on the long-term cognitive trajectories of older adults in 2 countries with different socioeconomic and health settings, and to determine whether this relationship differs by cognitive domains. This study uses Mexico and the United States to confirm if patterns hold in both populations, as these countries have similar diabetes prevalence but different socioeconomic conditions and diabetes-related mortality.

Methods
Two nationally representative cohorts of adults aged 50 years or older are used: the Mexican Health and Aging Study for Mexico and the Health and Retirement Study for the United States, with sample sizes of 18,810 and 26,244 individuals, respectively, followed up for a period of 14 years. The outcome is cognition measured as a total composite score and by domain (memory and nonmemory). Mixed-effect linear models are used to test the effect of diabetes on cognition at 65 years old and over time in each country.

Results
Diabetes is associated with lower cognition and nonmemory scores at baseline and over time in both countries. In Mexico, diabetes only predicts lower memory scores over time, whereas in the United States it only predicts lower memory scores at baseline. Women have higher total cognition and memory scores than men in both studies. The magnitude of the effect of diabetes on cognition is similar in both countries.

Discussion
Despite the overall lower cognition in Mexico and different socioeconomic characteristics, the impact of diabetes on cognitive decline and the main risk and protective factors for poor cognition are similar in both countries.
Neural Circuits Underlying Nest Building in Male Zebra Finches
Authors: Edwards Sophie C , Hall Zachary J , Ihalainen Eira , Bishop Valerie R , Nicklas Elisa T , Healy Susan D , Meddle Simone L 
Published: July 2020

AbstractNest building consists of a series of motor actions, which are concomitant with activity in regions of the anterior motor pathway, the social behavior network, and the reward circuity in nest building adult male zebra finches (Taeniopygia guttata). It is not clear, however, whether this activity is due to nest building, collection, and/or manipulation of nest material. To identify which areas of the brain are specifically involved, we used immunohistochemistry to quantify the immediate early gene c-Fos in male zebra finches that were nest building (Building), birds given a nest box but could interact only with tied down nest material (Fixed), and birds that were not given a nest box or nest material (Control). We investigated the following brain regions: the anterior motor pathway (anterior ventral mesopallium [AMV], AN, anterior striatum [ASt]), areas of the social behavior network (bed nucleus of the stria terminalis, dorsomedial subdivision [BSTmd], lateral septum [LS]), the dopaminergic reward circuitry (ventral tegmental area), and the cerebellum. We found that there was greater Fos immunoreactivity expression in the BSTmd, LS, and AMV with increased material deposition; in LS, AMV ASt, and Folium VI with increased material carrying; in LS, AMV, and ASt with increased nest material tucking; and in LS and all folia (except Folium VIII) with increased tugging at tied down material. These data confirm a functional role for areas of the anterior motor pathway, social behavior network, and the cerebellum in nest material collection and manipulation by birds.
Donor-Derived CD4+ T Cells and Human Herpesvirus 6B Detection After Allogeneic Hematopoietic Cell Transplantation
Authors: Hanson Derek J , Xie Hu , Zerr Danielle M , Leisenring Wendy M , Jerome Keith R , Huang Meei-Li , Stevens-Ayers Terry , Boeckh Michael , Koelle David M , Hill Joshua A 
Published: July 2020

Abstract
We sought to determine whether donor-derived human herpesvirus (HHV) 6B–specific CD4+ T-cell abundance is correlated with HHV-6B detection after allogeneic hematopoietic cell transplantation. We identified 33 patients who received HLA-matched, non–T-cell–depleted, myeloablative allogeneic hematopoietic cell transplantation and underwent weekly plasma polymerase chain reaction testing for HHV-6B for 100 days thereafter. We tested donor peripheral blood mononuclear cells for HHV-6B–specific CD4+ T cells. Patients with HHV-6B detection above the median peak viral load (200 copies/mL) received approximately 10-fold fewer donor-derived total or HHV-6B–specific CD4+ T cells than those with peak HHV-6B detection at ≤200 copies/mL or with no HHV-6B detection. These data suggest the importance of donor-derived immunity for controlling HHV-6B reactivation.
Influences on antibiotic prescribing by non-medical prescribers for respiratory tract infections: a systematic review using the theoretical domains framework
Authors: Chater Angel , Family Hannah , Lim Rosemary , Courtenay Molly 
Published: July 2020

Abstract

Background
The need to conserve antibiotic efficacy, through the management of respiratory tract infections (RTIs) without recourse to antibiotics, is a global priority. A key target for interventions is the antibiotic prescribing behaviour of healthcare professionals including non-medical prescribers (NMPs: nurses, pharmacists, paramedics, physiotherapists) who manage these infections.

Objectives
To identify what evidence exists regarding the influences on NMPs’ antimicrobial prescribing behaviour and analyse the operationalization of the identified drivers of behaviour using the Theoretical Domains Framework (TDF).

Methods
The search strategy was applied across six electronic bibliographic databases (eligibility criteria included: original studies; written in English and published before July 2019; non-medical prescribers as participants; and looked at influences on prescribing patterns of antibiotics for RTIs). Study characteristics, influences on appropriate antibiotic prescribing and intervention content to enhance appropriate antibiotic prescribing were independently extracted and mapped to the TDF.

Results
The search retrieved 490 original articles. Eight papers met the review criteria. Key issues centred around strategies for managing challenges experienced during consultations, managing patient concerns, peer support and wider public awareness of antimicrobial resistance. The two most common TDF domains highlighted as influences on prescribing behaviour, represented in all studies, were social influences and beliefs about consequences.

Conclusions
The core domains highlighted as influential to appropriate antibiotic prescribing should be considered when developing future interventions. Focus should be given to overcoming social influences (patients, other clinicians) and reassurance in relation to beliefs about negative consequences (missing something that could lead to a negative outcome).
MEDICINE AND COLONIAL PATENT LAW IN INDIA: A Study of Patent Medicines and the Indian Patents and Designs Act, 1911 in Early- Twentieth-Century India
Authors: Chowdhury Subhadeep 
Published: July 2020

ABSTRACT
This paper investigates the history of drugs sold as “patent medicines” in India in the early twentieth century. The paper investigates their legitimacy as patenting of medicines was forbidden by the Indian Patents and Designs Act, 1911 (IPDA). The paper argues that the instrument of letters patents functioning as the prerogative of the Crown that gave monopolistic rights to grantees to sell any compound without having to disclose its constituents was the reason behind this seemingly conflicting historical relationship between the law and the market. Colonial law-making left sufficient space within the ambit of the IPDA for letters patents to have their ill effects. The colonial state made attempts to address this as a public health issue by incorporating concerns related to this class of medicines within regulations addressed to the drugs market in the 1930s. The currency of patent medicines in the market was further added to by Indian indigenous entrepreneurs fueled by cultural nationalism of Swadeshi ideology in Bengal in the early twentieth century. However, even such indigenous responses or attempts at hybridization of manufacturing and selling practices related to patent medicines were mostly informed by upper-caste/ upper-class interests and not so much by those of consumers of these medicines.