bluuebunny/crossref_metadata_2025_split huggingface dataset:
OPTIMISM AND PAIN INTERFERENCE IN AGING WOMEN
Authors: Judge Stephanie T , Clasey Jodi L , Crofford Leslie J , Segerstrom Suzanne C 
Published: November 2019

Abstract
Pain limits individuals’ ability to engage in activities that promote well-being. This longitudinal-burst daily diary study tested reciprocal relationships among pain, optimism, pain interference, and activity in older women. Multilevel models tested between- and within-person relationships among these variables. Pain best predicted interference (person: γ001 = .227, SE = .022, p &lt; .0001; wave: γ010 = .267, SE = .014, p &lt; .0001; day: γ100 = .246, SE = .010, p &lt; .0001); optimism best predicted activity (γ002 = .684, SE = .101, p &lt; .0001). In linear regression models, baseline optimism (sr2 = 0.560, p &lt; .0001), less interference (sr2 = 0.064, p &lt; .0001), and more activity (sr2 = 0.015, p = .013) predicted higher end-of-study optimism. Ultimately, more optimistic women were significantly more active than less optimistic women, and less interference and more activity promoted increased optimism, creating a virtuous cycle that enhances well-being among older women.
GENDER DIFFERENCES IN THE PREVALENCE AND INCIDENCE OF COGNITIVE IMPAIRMENT: DOES IMMIGRATION MATTER?
Authors: Tang Fengyan , Tang Fengyan , Li Ke , Chi Iris , Dong XinQi 
Published: November 2019

Abstract
Using two waves of the PINE data, this study examined gender difference in the associations between immigration-related factors and cognitive impairment (CI). CI was assessed by the Chinese Mini-Mental State Examination (C-MMSE). CI prevalence was determined by C-MMSE &lt; 18 at baseline; incidence was the percentage of the respondents whose C-MMSE &gt; 18 at baseline but dropped below 18 at Wave 2. We found 7.62% CI prevalence and 5.12% incidence rate. Women were more likely than men to have CI, consisting of 77.06% and 75.20% among persons with CI at two time points. Older Chinese women were generally disadvantaged in cognition and overall health compared with older men. Yet immigration experience does not link to CI for both men and women after controlling the well-established effects of age and education. Future research needs to investigate what biological and contextual factors earlier in life are predictive of late-life CI risk.
EXPLORING THE MULTIDIMENSIONAL BIOPSYCHOSOCIAL PATHWAYS LINKING SOCIAL STATUS AND HEALTH AMONG OLDER ADULTS
Authors: Farmer Heather R , Thierry Amy , Wray Linda A 
Published: November 2019

Abstract
An abundant literature has documented the social patterning of health, where those with lower social status experience poorer outcomes relative to those with higher status. This symposium examines how social status (e.g., age, race/ethnicity, gender, and SES) impacts various aspects of midlife and older adults’ lives and their psychological and physical health. The research presented in this symposium lend support to utilizing a biopsychosocial framework for understanding mechanisms of health and aging. First, Heather Farmer et al. will explore race and gender differences in elevated C-reactive protein (CRP), a marker of inflammation linked to poor acute and chronic outcomes, using data from the Health and Retirement Study (HRS). Linda Wray and Amy Thierry will use HRS data to test whether race/ethnicity and sex interact to produce unequal outcomes in functional status. Jen Wong et al. will utilize data from the Midlife in the United States (MIDUS) survey to investigate the moderating influences of age, gender, marital status, and social support on caregiving and psychological well-being. Collin Mueller and Heather Farmer will use HRS data to examine how perceptions of unfair treatment are associated with healthcare satisfaction and self-rated health across Black, Latinx, and White subpopulations. Taken together, this work highlights the need for a comprehensive approach to better address physical and mental health disparities over the life course. After attending this session, participants will have a stronger understanding of how social status shapes important outcomes in older adults’ lives and some of the mechanisms responsible for these variations.
PUTTING THE CONTEXT BACK INTO THE DEBATE ON EXTENDED WORKING LIFE
Authors: Krekula Clary 
Published: November 2019

Abstract
Policy on extended working life has tended to focus on individuals. The debate has to a great extent described older people as the problem and their current retirement trends as problematic as well as selfish, uninformed, out-dated and a threat to welfare provision and benefits. This depicts the political initiatives as a phenomenon disconnected from social, political and economic trends. This presentation reintroduces the context, by locating the role of policies to extend working lives as forming part of a neoliberal policy agenda. Starting from the understanding that policies are proactive measures which focus on some aspects and play down others, this paper analyses international policies from the EU and OECD and also government policies from 34 European countries. The results draw attention to the narrow and contradictory ways in which the issue is often framed, and how this relegates related new inequalities to the background.
HOME HEALTH CARE AS A PREDICTOR OF SURVIVAL AMONG PEOPLE LIVING WITH ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
Authors: Jarrín Olga F , Nyandege Abner , Grafova Irina B 
Published: November 2019

Abstract
Over the past 10 years, dementia care has been shifting to the community; however, there are significant regional and sociodemographic differences in the use of formal home health care services. Does the use of home health care improve survival and other outcomes among people diagnosed with dementia? The aim of the study was to determine the individual, societal, and health systems predictors of survival after a diagnosis of dementia. Using linked Medicare administrative, claims, and assessment data (N = 4,349,565); we found that home health care significantly reduced risk of death for males, but not females. This effect was strongest among older adults between the ages of 65 and 80. While men who were living alone or in a congregate/assisted living environment benefited the most (O.R. = 0.87) the effect was also strong for men living with a spouse or other caregiver (O.R. = 0.90). These findings suggest home health care may provide a survival advantage for men through the provision of rehabilitative and supportive services, as well as patient and family caregiver education. Further research is needed to understand if sex based survival differences are associated with the intensity of home health care services provided or social determinants of health.
SUICIDE RISK ASSESSMENT AND MANAGEMENT IN THE CONTEXT OF TRANSITION TO LONG-TERM CARE
Authors: Lane Douglas W 
Published: November 2019

Abstract
The transition from independent living to living in a supported care facility can create significant emotional stress for the older person undergoing the move. From the perspective of suicide risk management, it is vital to appreciate the potential increase in risk associated with this period of adjustment. In this case-based talk, we will discuss key issues in assessing and managing suicide risk in this context. Factors in risk management to be discussed include the person’s social/family context, baseline psychological status, coping assets, and intraindividual values and diversity characteristics. Emphasis will be placed on the need for active assessment, mobilization of resiliency factors, and monitoring during the phase of adjustment. The need to ensure coordination of care across settings will be discussed as well. Finally, we will identify the ways in which the transition can be undermined by ageism on the part of professionals and/or the person’s loved ones.
HARDWIRED BIOLOGY AND LIGHT-BULB MOMENTS: DIVERGENT DISCOURSES AND LIFE TRAJECTORIES OF OLDER BISEXUAL WOMEN
Authors: Jen Sarah 
Published: November 2019

Abstract
Older bisexual women report a less positive sense of their sexual identity, less belonging in LGBTQ communities, and worse mental health outcomes compared to lesbian counterparts. These patterns are consistent with those identified among younger bisexual cohorts and appear to be connected to how bisexual identities are perceived and experienced; however, sexual identities take on unique meaning by gender and age and across historical contexts. To explore how older bisexual women construct and make meaning out of bisexual identities, this study applied a Foucauldian discursive and critical feminist conceptual framing to examine semi-structured interviews with bisexual women ages 60 and older (N=13). Findings reveal two divergent groups of women, the Early Emergers and Mature Migrators, who differ in their constructions of bisexuality and the timing of their first experienced attractions to other women. While the Early Emergers construct bisexuality as a stable, “hardwired” biological concept, the Mature Migrators challenge this narrative by emphasizing the fluidity of sexuality through discourses of migration spurred by “light bulb” moments in which they first recognized their attractions to women. This study illustrates the contributions of discourse analysis in revealing nuanced constructions of life course histories as well as the need for acknowledgment of life context in research and practice with older bisexual individuals. Scholars and practitioners must intentionally critique and contribute to discourses of bisexuality in later life.
PRODUCTIVE ACTIVITIES AND LONELINESS AMONG JAPANESE MIDLIFE AND OLDER ADULTS
Authors: Wang Yang , Wang Yihan , Kohlbacher Florian , Gonzales Ernest 
Published: November 2019

Abstract
Background: Loneliness among older population is a public health concern shared worldwide. Using the motivational theory for life-span development, this study examined the associations between loneliness (social and emotional) and productive activities among midlife and older adults in Japan. Methods: The Japanese National Data on Lifestyle and Mental Health, a nationally representative sample of midlife and older adults (2011, N=1,575), were used to examine how employment, volunteering, helping family and friends, and informal caregiving was associated with social and emotional loneliness, controlling for multiple risk and protective factors. Results: Family caregiving was related to more social loneliness. Working, helping family, and volunteering were related to less emotional loneliness, while family caregiving was related to more emotional loneliness. Japanese male caregivers reported more social isolation compared to female caregivers. Face-to-face interactions reduced emotional loneliness among caregivers. Discussion: Findings underscored the nuanced difference of social loneliness and emotional loneliness. Social policies that advance productive aging should recognize “unintended consequences” and aim to protect older adults from social and emotional loneliness. Counselling services and social support programs specifically for Japanese male caregivers are warranted.
HETEROGENEITY IN MULTIDIMENSIONAL DEPENDENCY IN OLDER ADULTS IN MEXICO: A LATENT CLASS ANALYSIS APPROACH
Authors: Rely Kely , Vargas-Chanes Delfino , García-Peña Carmen , Gutiérrez-Robledo Luis Miguel , Wong Rebeca , Ramírez-Aldana Ricardo 
Published: November 2019

Abstract
Background: The number of older adults expected to increase over the coming decades, the public health impact in this population may be substantial, and a greater understanding of the structure underlying risk factor presentation as a potential source of heterogeneity is critical. Objective: Identify and characterize profiles of dependency status in a population of dependent elderly individuals. Methods: The present study is based on the first wave of the Mexican Health Aging Study (MHAS). We included subjects aged 50 or older (n = 13,463 respondents interviewed in 2001). We performed Latent Class Analysis on four domains in older adults’ indicators (physical, psychological, economic and social) to identify distinct classes of dependency profiles. We used LCA to group individuals into homogenous categories of dependency based on observed domains of multidimensional dependency. Multivariable logistic regression was conducted to examine the sociodemographic characteristics associated with each profile. Results: A 4-class solution based on cognitive performance at baseline was the best-fitting model. We characterized the four distinct classes of dependency profiles: active older adult, low, moderate and severe dependency that encompassed multiple dimensions of dependence. Using the “active older adult” class as the reference group, severe dependency, low dependency, and moderate dependency class were more likely to contain females, low education level and poor quality of life 3) the moderate dependency class was less likely to contain cigarette smoking and alcohol user. Conclusions: This study suggests that dependency do not follow a uniform adjustment pattern during the aging process, which reconciles inconsistent previous findings.
IS YOUR COMMUNITY-BASED HEALTH PROMOTION PROGRAM EVIDENCE BASED AND READY FOR DISSEMINATION? HERE’S HOW TO FIND OUT
Authors: Schneider Ellen C , Steinman Lesley , Dicocco Casey 
Published: November 2019

Abstract
Evidence-based programs (EBPs) offer proven ways to promote health and prevent disease among older adults in their communities. EBPs are based on rigorous study of the effects of specific interventions or model programs, demonstrate consistently positive changes in important health-related and functional measures, and have tools in place to maintain program access, quality, and efficiency across diverse settings. The University of North Carolina at Chapel Hill’s Center for Health Promotion and Disease Prevention (UNC HPDP), in partnership with the Evidence-Based Leadership Collaborative (EBLC), has established a review process and Review Council to identify new community programs that meet the evidence-based program criteria established by the Administration for Community Living (ACL), one of the chief U.S. federal agencies responsible for aging programs. Approved programs are then eligible for Older Americans Act Title III-D and other discretionary funding to support organizations that deliver EBPs to improve older adult health. The review process assesses the effectiveness, outcomes, and evaluation of the program, information about program implementation, training, and other key elements for successful program dissemination. The Review Council consists of national leaders with expertise in program research, evaluation, and implementation. The review process is supported by the ACL-funded National Chronic Disease Self-Management Education and Falls Prevention Resource Centers. This session will describe the ACL evidence-based health promotion program criteria that must be met for approval; an overview of the review process; and how researchers can submit their programs for review. Time will be allowed for questions, discussion, and research to practice implications.
COLLABORATIVE AGING RESEARCH USING TECHNOLOGY: NEW PATHWAYS FORWARD
Authors: Kaye Jeffrey , Beattie Zachary , Sharma Nicole , Riley Thomas , Silbert Lisa , Barnes Lisa , Czaja Sarah , Dodge Hiroko 
Published: November 2019

Abstract
A profusion of technologies and protocols have been developed to more effectively assess and deliver care to older adults with cognitive impairment, challenged health and declining function. These technologies take advantage of important developments in sensing and pervasive computing, wearable technologies, mobile and wireless communications, and “big data” analytics. Despite great promise challenges remain to realizing their full potential and achieving wider uptake and dissemination in research and practice. This presentation will review and provide an overview of major technologies, their integration, and their use-cases, as well as key challenges present in the current landscape. The presentation will highlight ongoing developments addressing these challenges with particular attention to the Collaborative Aging Research using Technology (CART) initiative supported by the NIH and VA, an initiative directed toward providing an open technology research platform to be used by diverse investigators across the U.S. to facilitate and improve aging research using technology.
THE GUT MICROBIOME AND AGING
Authors: Carter Christy S , Masternak Michal , Buford Thomas W 
Published: November 2019

Abstract
The human intestinal tract (i.e., “gut”) is inhabited by over 100 trillion microorganisms; including over 1000 species of known bacteria. These organisms have co-evolved with humans over millennia to live together for mutual benefit. Though long overlooked in considerations of human health and disease treatment, gut microorganisms are highly involved in numerous metabolic reactions which influence normal host physiology. A variety of biologic, medical, and lifestyle factors appear to contribute to gut dysbiosis in late-life, and interventions specifically designed to target these factors may be useful in restoring microbial balance. Evidence from both clinical and preclinical studies suggests that gut dysbiosis is related to age-related inflammation as well as age-related conditions including frailty, Alzheimer’s disease, and perhaps even longevity. Crosstalk between the gut and multiple organ systems (brain, heart, muscle etc.) may lead to the development of age-related diseases and loss of physiological function, although the signals are not well understood. In this symposium we address the broad topic of the Gut Microbiome and Aging by presenting evidence from multiple model systems (mice, rats and monkeys) and provide a forum to discuss critical areas of research for moving forward.
TRANSGENIC MOUSE MODELS OF ALZHEIMER’S DISEASE
Authors: Henry-Smith Charnae A , Han Xianlin 
Published: November 2019

Abstract
Alzheimer’s disease is a progressive brain disease that slowly destroys memory and thinking skills. Alzheimer’s is characterized by an increase in Aβ plaques , and tau tangles. Neurons in the brain have axons covered in myelin sheath that connect microglia and astrocytes. The myelin sheath is composed of about 70% lipid composition; Sulfatide contributing to 30% overall. Sulfatide changes the morphology of primary microglia to their activated form. To study the role of microglia activation and sulfatide levels, three different mouse models were created: APP KI mice, CST Whole Body Ko mice, and cCST (conditional) KO. In order to create the genotype of the APP KI mice, a breeding mouse line was created. The APP KI gene had to be introduced in Plp1-Cre and cCST KO crossed mice to receive a working mouse model. During the duration of breeding for the APP KI mice, a preliminary experiment was performed on the CST KO mice. These mice were given the PLX3397 diet with the aim to remove the microglia and to see the effect of Aβ plaques. The PLX3397 will reduce the microglia targeting the CSF1R. After consuming the diet, the mice were harvested to collect tissues from the brain and spinal cord. Lipidomics and immunohistology were performed. In conclusion, we will continue the breeding of the CST flox/flox / Plp1-Cre / APP KI mice, and the drug dosage and treatment to be used in our APP KI mice will be based on preliminary data from our CST mice.
PERCEPTIONS OF PERPETRATORS OF AGEISM
Authors: Chasteen Alison L , Horhota Michelle , Crumley-Branyon Jessica 
Published: November 2019

Abstract
What are the consequences for perpetrators who engage in different types of ageism? We compared young (n=316), middle-aged (n=464), and older adults’ (n=273) perceptions of a perpetrator who engaged in an ageist action. Participants read a vignette about a pedestrian (the perpetrator) offering unwanted help to an older woman crossing the street. We manipulated the ageism type (benevolent or hostile), the reaction of the older target (acceptance, moderate confrontation or strong confrontation) and assessed the overall impression of the perpetrator. Main effects emerged for Ageism Type and Age Group. Overall, participants rated the perpetrator more positively in the benevolent condition compared to the hostile condition. Middle-aged and older adults rated the perpetrator more positively than young adults did. A Time x Confront interaction suggested that the perpetrator’s overall impression was not impacted when the target of the ageist act accepted the action or moderately confronted the perpetrator. In contrast, when the target confronted the perpetrator strongly, the overall impression of the perpetrator decreased. An Ageism Type x Age Group x Time interaction on overall impression also emerged. There were no age differences when the perpetrator committed a hostile act of ageism. In contrast, in the benevolent condition young and older adults perceived the perpetrator more negatively after the target’s reaction, whereas middle-aged adults did not adjust their impression. Taken together, these results suggest that young and older adults may be less accepting of benevolent ageism compared to middle-aged adults.
INVESTIGATING THE ROLE OF AHR IN MEDIATING SEX DIFFERENCES OF AGING MACROPHAGES
Authors: Navar Evelyn , Benayoun Bérénice A , Sampathkumar Nirmal , Chae Jisoo 
Published: November 2019

Abstract
“Inflamm-aging” describes a state of chronic low-grade inflammation which occurs with age in the absence of infection. This process is related to many chronic age-related diseases. Aryl hydrocarbon receptor (Ahr), is a transcription factor that is thought to decrease inflammation, and decrease of Ahr with aging only in females was previously observed in a macrophage RNA-seq with aging. Based on this, I hypothesized that 1) Ahr expression will decrease with age in female cells; and 2) phagocytic activity and Ahr expression in macrophages will increase when exposed to estrogens (E2). To test these hypotheses, Ahr signaling was quantified by RT-qPCR in aging male and female mice BMDMs, and in macrophages that were treated with E2. I also performed a phagocytosis assay on macrophages treated with E2. I found a significant downregulation of Ahr in old female BMDMs. Ahrr (Ahr Repressor) was significantly downregulated in both old female and males with aging. Arnt (Ahr Nuclear Translocator) did not significantly change with aging. The qPCR performed on the E2 treated cells showed no significant trend for Ahr regulation. Finally, the phagocytosis assay revealed an overall increase in phagocytosis activity in cells treated with estrogen. Our hypotheses were supported by data showing a decrease in Ahr expression with age and increase in phagocytosis activity in estrogen treated cells. The RT-qPCR results for the E2 treated cells did not support our hypothesis, but could stem from a relatively short exposure time for estrogen.