bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quelle approche « réaliste » de la montagne en géographie : l’exemple des bourrelets de marge passive
Authors: Pech Pierre , Séguier Romane 
Published: June 2020

La montagne constitue un objet incontournable de la géographie mais, au même titre que d’autres objets, elle oppose, une approche offrant des éléments de description et d’explication fondés sur une représentation réaliste et avant tout géologique à une autre plus récente prenant en compte les représentations des populations. Pour la géographie enseignée mais aussi pour l’usage qui en est fait d’un point de vue législatif en France avec la Loi montagne, l’approche réaliste domine. La question est de savoir si celle-ci, qui fonde une approche normative de la montagne est toujours valide au regard des avancées scientifiques les plus récentes. Les bourrelets de marge passive, montagnes emblématiques de la géographie physique, sont ici envisagés à titre d’exemple d’un type de montagne à partir d’une analyse approfondie de la littérature scientifique. Deux points en ressortent : la mise en place récente de ces montagnes, comme toutes les montagnes à la surface de la terre, et la variété de leur évolution. Mettre la science géographique en débat ici ne consiste pas à détruire son statut dans sa fonction d’action cognitive, notamment au service d’usages demandés par la société, mais de reconnaître les biais et les limites de certaines connaissances.
Horreur agréable et terreur sublime, deux visions poétiques anglaises du conte de fées français au XVIII e siècle
Authors: Sermain Jean-Paul 
Published: June 2020

Dès la fin du xvii e siècle, Perrault et ses amies ont donné à la terreur un rôle fondateur dans le nouveau genre du conte de fées. C’est Addison qui en 1712, dans le Spectator , s’appuie sur ces exemples pour concevoir son esthétique de « l’horreur agréable ». Burke radicalise son propos en 1757 avec la théorie de « la terreur sublime », qui vient s’appliquer aux contes de d’Aulnoy, de Villeneuve et de son compatriote francophone Beckford. Cette veine originale, ainsi déployée dans les œuvres et les réflexions poétiques des deux côtés de la Manche pendant un siècle, vient ensuite nourrir la nouvelle fantastique romantique, tandis que Grimm et Andersen s’en emparent pour en changer radicalement le sens et la portée.
Marie-Jeanne Roland : une âme forte au milieu des Pygmées
Authors: Vázquez Lydia 
Published: June 2020

Marie-Jeanne Roland est guillotinée le 8 novembre 1793. « Femme forte » du gouvernement Roland dirigé par son mari, elle écrit en prison des Mémoires particuliers et des Notices historiques , en attendant « l’honneur d’aller à l’échafaud ». Témoignage unique d’une femme qui écrit sous le signe de la vérité, se sachant condamnée. Témoignage forgé sous le signe du paradoxe car, tout en se déclarant innocente face aux accusations de ses bourreaux, car elle « n’est qu’une femme », elle s’affirme supérieure à ces « êtres pusillanimes », ces « hommes qui n’en méritent pas le nom » et qui dirigent la destinée des Français en cette période de terreur.
Damnatio memoriae
Authors: Lavernhe-Grosset Anita 
Published: June 2020

Contre l’histoire officielle, Histoire d’un crime dénonce le Coup d’État du 2 décembre 1851. Victor Hugo décrit l’échec des résistants à une nouvelle Terreur qui va ruiner la République et l’héritage des Lumières . L’écrivain obéit à un impératif moral et politique de vérité historique destinée à ses contemporains et aux générations futures. Représentant du peuple et proscrit, il sera la voix universelle des témoins et des victimes. Entre singularité et pluralité, le récit doit dès lors inventer de nouvelles stratégies dans son exigence paradoxale d’objectivité, de captatio benevolentiae et de visée axiologique.
« Remettre en scène » des ballets : Jean Aumer au théâtre de la Porte-Saint-Martin, 1802-1805
Authors: Olivesi Vannina 
Published: June 2020

Le présent article propose d’examiner la pratique des « remises en scène » des ballets à travers le cas de Jean Aumer, maître de ballet au théâtre de la Porte-Saint-Martin qui s’approprie le répertoire de prédécesseurs, Jean Dauberval et Jean-Baptiste Blache. S’appuyant sur la correspondance professionnelle de ces artistes, l’auteur met en perspective les différentes significations de cette pratique dans un contexte de définition de l’auctorialité en danse théâtrale. La comparaison des programmes du Déserteur de Dauberval (1785) et d’Aumer (1804) permet enfin de déterminer le rôle joué par la réécriture de chacun dans la remise en scène des ballets.
Poétique(s) de la mise en scène au Théâtre d’Art (1890-1892)
Authors: Folco Alice 
Published: June 2020

Cette contribution entend réexaminer l’activité du Théâtre d’Art dirigé par Paul Fort entre 1890 et 1892 à l’aune des travaux récents portant sur l’histoire de la mise en scène, non tant pour lui revendiquer une place de « pionnier » dans l’émergence de la mise en scène moderne, que pour compléter le tableau de nos connaissances sur la vie théâtrale de la fin du xix e siècle, en essayant de mieux cerner les pratiques qui y furent expérimentées. Après avoir considéré la variété des définitions explicites ou implicites du processus de mise en scène évoquées par les programmes, articles de presse et souvenirs des témoins, l’auteur s’intéresse à la revendication d’une approche « dramaturgique » (au sens contemporain d’analyse du matériau textuel ayant vocation à orienter la réalisation de la représentation), puis au statut revendiqué pour les personnes chargées de l’« ordonnance scénique » (Paul Fort, Pierre Quillard, Paul-Napoléon Roinard, Adolphe Retté, Charles Morice, etc.).
IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation againstStreptococcus pneumoniaePathogenesis
Authors: Schmit Taylor , Ghosh Sumit , Mathur Ram Kumar , Barnhardt Tyler , Ambigapathy Ganesh , Wu Min , Combs Colin , Khan M. Nadeem 
Published: June 2020

AbstractAllergic asthma (AA) is characterized as a Th2-biased airway inflammation that can develop lung inflammation and remodeling of the respiratory tract. Streptococcus pneumoniae is a major respiratory pathogen, causing noninvasive (otitis media and pneumonia) and invasive diseases (sepsis) in humans. We sought to determine the role of IL-6 in the regulation of lung inflammation in murine AA caused by Aspergillus fumigatus as well as its consequence on the regulation of airway barrier integrity and S. pneumoniae disease. In an AA model, IL-6 deficiency led to increased lung inflammation, eosinophil recruitment, tissue pathology, and collagen deposition. Additionally, IL-6–deficient asthmatic mice exhibited reduced goblet cell hyperplasia and increased TGF-β production. These key changes in the lungs of IL-6–deficient asthmatic mice resulted in dysregulated tight junction proteins and increased lung permeability. Whereas the host response to AA protected against S. pneumoniae lung disease, the IL-6 deficiency abrogated the protective effect of allergic inflammation against S. pneumoniae pathogenesis. Consistent with in vivo data, IL-6 knockdown by small interfering RNA or the blockade of IL-6R signaling exacerbated the TGF-β–induced dysregulation of tight junction proteins, E-cadherin and N-cadherin expression, and STAT3 phosphorylation in MLE-12 epithelial cells. Our findings demonstrate a previously unrecognized role of host IL-6 response in the regulation of lung inflammation during AA and the control of S. pneumoniae bacterial disease. A better understanding of the interactions between lung inflammation and barrier framework could lead to the development of therapies to control asthma inflammation and preserve barrier integrity.
Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes
Authors: Jeong Yun Hee , Walsh Matthew C. , Yu Jiyeon , Shen Hao , Wherry E. John , Choi Yongwon 
Published: June 2020

Abstract
P2X5 is a member of the P2X purinergic receptor family of ligand-gated cation channels and has recently been shown to regulate inflammatory bone loss. In this study, we report that P2X5 is a protective immune regulator during Listeria monocytogenes infection, as P2X5-deficient mice exhibit increased bacterial loads in the spleen and liver, increased tissue damage, and early (within 3–6 d) susceptibility to systemic L. monocytogenes infection. Whereas P2X5-deficient mice experience normal monocyte recruitment in response to L. monocytogenes, P2X5-deficient bone marrow–derived macrophages (BMMs) exhibit defective cytosolic killing of L. monocytogenes. We further showed that P2X5 is required for L. monocytogenes–induced inflammasome activation and IL-1β production and that defective L. monocytogenes killing in P2X5-deficient BMMs is substantially rescued by exogenous IL-1β or IL-18. Finally, in vitro BMM killing and in vivo L. monocytogenes infection experiments employing either P2X7 deficiency or extracellular ATP depletion suggest that P2X5–dependent anti–L. monocytogenes immunity is independent of the ATP-P2X7 inflammasome activation pathway. Together, our findings elucidate a novel and specific role for P2X5 as a critical mediator of protective immunity.
Elevated serum leptin levels are associated with low muscle strength and muscle quality in male patients undergoing chronic hemodialysis
Authors: Hsu Bang-Gee , Wang Chih-Hsien , Lai Yu-Hsien , Kuo Chiu-Huang , Lin Yu-Li 
Published: June 2020

Objectives:
Low muscle strength and poor muscle quality are highly prevalent in patients with chronic hemodialysis (HD), which lead to an increased risk of poor clinical outcomes. Leptin dysregulation is common in HD patients. Given that leptin receptors are abundant in skeletal muscle, there may be a link between leptin and muscle strength. The cross-sectional study aimed to explore the correlation of serum leptin levels with muscle strength and muscle quality in patients with chronic HD.

Materials and Methods:
A total of 118 chronic HD patients were included in this study. Basic characteristics, handgrip strength, body composition were assessed, and blood samples for serum leptin levels and other biochemical test were obtained. We defined skeletal muscle index (SMI) as skeletal muscle mass/height2 (kg/m2) and muscle quality as handgrip strength divided by mid-arm muscle circumference (MAMC). Patients were classified into tertile groups, according to sex-specific leptin levels.

Results:
We observed that patients in the higher leptin tertile tend to have a higher body weight, body mass index (BMI), body fat mass, MAMC, and SMI, while the handgrip strength and muscle quality were significantly lower. Bodyweight (r = 0.30; P = 0.001), BMI (r = 0.45; P = 0.001), body fat mass (r = 0.57;P < 0.001), and SMI (r = 0.22; P = 0.018) were positively and handgrip strength (r = −0.27; P = 0.003) and muscle quality (r = −0.35;P < 0.001) were negatively correlated with serum leptin levels, respectively. After adjusting multiple confounding factors, logarithmically transformed serum leptin levels were independently associated with handgrip strength (β = −3.29, P = 0.005) and muscle quality (β = −0.14, P = 0.009). However, gender-stratified models showed the associations were observed only in male, but not in female.

Conclusion:
We concluded that higher serum leptin levels are associated with low handgrip strength and poor muscle quality in male patients on chronic HD. Further studies are needed to clarify the gender differences and to evaluate the casual relationship between circulating leptin levels and muscle strength.
PENDIDIKAN AKHLAK PADA ANAK USIA DINI PERSPEKTIF ISLAM
Authors: HAMZAH HAMZAH 
Published: June 2020

Pendidikan akhlak kepada anak merupakan hal yang sangat penting dilakukan oleh orangtua. Pendidikan akhlak ini tidak bisa diabaikan oleh orangtua, karena fungsi dan kedudukan orangtua tidak hanya memberikan aspek materi saja, tetapi harus memperhatikan dan mengarahkan perilaku anak-anaknya kepada yang baik sesuai ajaran Islam. melalui tahapan-tahapan, yaitu pengenalan akan penciptanya, berbuat baik kepada orangtua, mendirikan sholat, berkewajiban menyeruh kepaada kebaikan dan mencegah perbuatan mungkar, tidak sombong pada sesame manusia. Tahapan-tahapan ini dilakukan melalui keteladanan, pengajaran, motivasi, pembiasaan dan pemberian saanksi. Hal ini dilakukan untuk melahirkan kehidupan yang bermoral, menjadikan hidup yang bermanfaat dan mengenal dan cinta kepada penciptanya dan sesama manusia.
ISLAM DAN KESETARAAN GENDER
Authors: Gani Rusna 
Published: June 2020

Pada dasarnya semua orang sepakat bahwa perempuan dan laki-laki berbeda. Namun, gender bukanlah jenis kelamin laki-laki dan perempuan sebagai pemberian Tuhan. Gender lebih ditekankan pada perbedaan peranan dan fungsi yang ada dan dibuat oleh masyarakat. Dalam realitas kehidupan telah terjadi perbedaan peran sosial laki-laki dan perempuan yang melahirkan perbedaan status sosial di masyarakat, dimana laki-laki lebih diunggulkan dari perempuan melalui konstruksi sosial. Perbedaan gender antara laki-laki dan perempuan ditentukan oleh sejumlah faktor yang ikut membentuk, yang kemudian disosialisasikan, diperkuat, bahkan dibentuk melalui sosial atau kultural, dilanggengkan oleh interpretasi agama dan mitos-mitos. Perbedaan jenis kelamin sering dipergunakan masyarakat untuk membentuk pembagian peran (kerja) laki-laki dan perempuan atas dasar perbedaan tersebut. Akibatnya terjadilah pembagian peran gender yaitu peran domestik dan peran publik. Peran domestik cenderung tidak menghasilkan uang, kekuasaan, dan pengaruh. Peran ini lebih banyak diserahkan kepada kaum perempuan, sedangkan peran publik yang menghasilkan uang, kekuasaan dan pengaruh diserahkan kepada kaum laki-laki. Akibat pembagian kerja yang tidak seimbang melahirkan ketimpangan peran laki-laki dan perempuan yang berakibat ketidakadilan gender yang merugikan perempuan
Peranan PT. Permodalan Ekonomi Rakyat (PER) Dalam Peningkatan Ekonomi Masyarakat Di Provinsi Riau
Authors: Fahrial  , Fatriani Rini , Jenita  
Published: June 2020

PT. PER as society wervice institution and PAD source in the economic crisis condition still exist and felt its role. The people economic improvement faces complex problem. The activities in the real sectors grow and will need huge capital. The role of PT. PER will be importanc in improving the society economic. The society economic development and improvent faces complex problem such as : the difficulty in accessing capital, the low of human resoureces quality, the limited technology mastering, the wenk management (financial and marketing), the low quality product and the weak institution and the institution arrangement in developing and empowering the people economic still non optimum. In the problems formulation, the writer discloseded qualitative and quatitative data. The results tried to describe the phenomenon about the PT. PER roles in improving the society economic at Riau Province. The results showed that during four years operation, ther is credit channeling improvement from year to year. PT. Permodalan Ekonomi Rakyat (PER) able to be “agent of development” in the economic recovery, able to distribute economic factors more evenly to people and has big multiplier effect. With PT. PER presence, the micro, small, middle business and cooperative and financial institution of Bank (BPR/S) and micro financial institution (UEK/D-SP), BMT) farmer group and other that formerly difficult to obtained business capital able to access PT. PER.The othe positive impact is PT. PER also contribute in illuminating the society attitude become bank minded.
Lise Öğrencilerine Özgü Matematik Kaygısı ve Matematik Kaygısı Ölçeğinin (MKÖ)’nin Uygulanmasına Dair Bir Değerlendirme
Authors: KOÇER Zeliha 
Published: June 2020

Bu çalışma;
öğrencilerde görülen matematik kaygısının seviyesini tespit etmede kullanılan
daha önce geliştirilmiş Matematik Kaygı Ölçeği'ni kullanmak ve ilerleyen
dönemde yapılan norm çalışmalarına temel oluşturacak bilgilere ulaşmak amacıyla
yapılmıştır. Çalışma lise öğrencilerini kapsamaktadır. Onların matematiğe olan
kaygılarında sınıf düzeyi, branş, cinsiyet, matematik dersi son sınav notu
bakımından anlamlı bir değişiklik olup olmadığını araştırmaktadır. Çalışmada
MKÖ Matematik Kaygısı Ölçeği bilgi toplama aracı olarak kullanılmıştır.
Çalışmanın örneklemi özel bir lisede öğrenim gören 90 öğrencidir. 2018-2019
eğitim-öğretim yılının birinci döneminde uygulama yapılmıştır. ANOVA ve T-Testi
hipotezlerin testi için tercih edilmiştir. Araştırma sonucunda istatistiksel
olarak öğrencilerin branşı, cinsiyeti ile yaşadıkları matematik kaygısı
arasında anlamlı bir fark görülmemiştir. Fakat öğrencilerin matematik son
sınavı notu ile sınıf düzeylerine göre
matematik kaygılarında anlamlı bir fark yaşandığı gözlemlenmiştir.
Myrcene enhances the cardioprotective effect through matrix remodelling in an experimental model of heart failure
Authors: Tian Jiawei , Zhang Rui , Weng Yunqi , Qin Qiaoji , Zhang Xuezhi , Liu Aiguo , Lin Nan 
Published: June 2020

IntroductionMyrcene, a terpene found in essential oils sourced from plants, is known to elicit various biological effects such as antioxidant, anti-inflammatory, hypoglycaemic, and hepatoprotective activities. However, reports on the protective effect of myrcene against heart failure are still not clear. Hence, in the present study, the experimental model of heart failure was induced using isoproterenol in rats.Material and methodsWistar male rats were divided into four groups: group I – Control; group II – ISO-induced heart failure; group III – Myrcene pre-treated (1.0 mg/kg/day and ISO); and group IV – Myrcene drug control for the experimental period of 4 weeks. At the end of the treatment, infarct size, cardiac markers, cell stress enzymes such as creatinine kinase, lactate dehydrogenase, inflammatory markers, matrix proteins, and microRNA signatures were elucidated using RT-PCR, ELISA, and immunohistochemistry analysis.ResultsRats with induced heart failure demonstrated abnormality in cardiac functions and marker gene expressions, while myrcene pre-treated rats prevented cardiac failure significantly (p < 0.001) with restoration of cellular functions. Also, myrcene pre-treatment abrogated the inflammatory signals with restored matrix proteins. Furthermore, the microRNA of matrix signalling pathways were also found to be prominently reduced compared to heart failure rats.ConclusionsMyrcene protected hearts from ISO-induced failure in rats and provided a cardioprotective effect via restoring the matrix signalling, anti-inflammatory, and antioxidant effect, which suggests a possible drug candidature for the treatment of cardiac failure.
Comparative tolerability of targeted therapies in pulmonary hypertension
Authors: Jasińska-Stroschein Magdalena , Stawarczyk Karolina , Stępień Anna , Orszulak-Michalak Daria 
Published: June 2020

IntroductionThe objective of this study was to estimate the safety profile of pulmonary hypertension-specific therapies using placebo-controlled and active comparator trials.Material and methodsThe search corpus comprised Medline, Scopus, Embase and Clinical Trials databases. A systematic review and meta-analysis was performed to assess the relative risk of severe events and discontinuations as well as of adverse drug reactions (ADRs) classified into 26 categories and 21 subcategories defined by the Medical Dictionary for Regulatory Activities (MedRA).ResultsPulmonary hypertension-specific therapies had the greatest effect on such events as flushing and headache as well as jaw pain, limb pain and myalgia or gastrointestinal disorders. The relative risk for ADRs in patients receiving monotherapy (vs. placebo/supportive therapies) and combined regimens (vs. monotherapy) was significantly increased. The risk of cessation for the combined regimen was slightly higher (Q<sub>inter-group</sub>, p = 0.0778). Such ADRs as blood and lymphatic system disorders with the anemia subgroup, gastrointestinal disorders with diarrhea and nausea subgroups, respiratory and thoracic diseases or nervous system disorders with headache tended to occur more often in combination regimens as compared to monotherapy.ConclusionsAbout half of the main categories and subcategories of adverse reactions according to MedRA were associated with a relatively high frequency and hazard ratio. Their risk can be increased when combination regimens are used, especially.
De wachtlijstproblematiek ‘knaagt’ aan de rechten van kinderen in gesloten jeugdhulp
Authors: de Jong-de Kruijf M.P. 
Published: June 2020

De wachtlijstproblematiek ‘knaagt’ aan de rechten van kinderen in gesloten jeugdhulp
Er is sprake van een forse wachtlijstproblematiek in de gesloten jeugdhulp. Het gebrek aan een passende (doorstoom)plek voor kinderen in gesloten jeugdhulp is soms zo nijpend dat kinderrechters een machtiging voor gesloten jeugdhulp verlengen in weerwil van het ontbreken van een materiële rechtsgrond of formele rechtswaarborgen uit de Jeugdwet. Er wordt daarbij een beroep gedaan op art. 3 lid 1 IVRK. Het is maar zeer de vraag of dit een wenselijke praktijk is. Er worden handvatten aangereikt vanuit General Comment no. 14 van het VN-Kinderrechtencomité.
Prevalence and Antimicrobial Susceptibility Profile of Uropathogens in Children Attending Tertiary Health Care Centre in Enugu, Nigeria
Authors: Maduakor C. Uzoamaka , Ohanu E. Martin , Udoh P. Iniekong , Onyebueke E. Adaeze , Okonkwo N. Innocent , Ihezue O. Assumpta 
Published: June 2020

Infections of the urinary tract are one of the most prevalent bacterial infections in developing countries. It is a challenge that is most often encountered in pediatrics. Uncontrolled use of antimicrobial drugs has led to the development of drug-resistant organisms. Hence, this study was aimed at isolating, characterizing, and identifying the pathogens associated with urinary tract infection (UTI) in children attending Tertiary Health Care Centre in Enugu metropolis and to determine their antimicrobial susceptibility profiles. Urine samples were collected from 260 patients with signs and symptoms suggestive of urinary tract infection (UTI). The children were seen in children out-patients, children emergency departments of the hospital, and pediatric ward. Their ages ranged from 0-17 years. The urine samples were analyzed in the laboratory using standard bacteriological methods. Antibiotic sensitivity of the isolates was determined by the Kirby-Bauer disc diffusion technique. Of the 260 urine samples, significant bacterial agents were recorded in 98(37.7%). Escherichia coli ranked highest with 30(32.6%) followed by Klebsiella spp. 17(18.5%) and the least was Enterococcus fecalis 1(1.1%). Gender distribution showed a higher prevalence in females (p <0.05). The highest positive result was obtained from children between 0-5years. Most of the isolates were sensitive to Imipenem, Nitrofurantoin, Ceftriaxone, and Ciprofloxacin but resistant to Augmentin and Amoxicillin. There is a need to regularly monitor the antimicrobial susceptibility profile of these etiological agents to keep track of the effectiveness of certain therapeutic agents.