bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fundraising and grant writing as a special financial mechanism of scientific projects international support
Authors: Demuz Inna 
Published: December 2019

The subject of the study is fundraising and grant writing technologies. The purpose of the study is to characterize the status of international grant financing of science in Ukraine in the context of fundraising and grant writing technologies. Methods of the study: generalization, analysis and synthesis, descriptive, statistical. Results and conclusions of work. The article analyzes the distribution of total expenditures for scientific and research work conducting by Ukrainian researchers based on funding sources. At the same time, a tendency was observed regarding the growth of the amount of financing the scientific and research works at the expense of foreign sources, i.e. grants. The emphasis was placed on the active participation of scientists in the implementation of various international project proposals in the context of significant underfinancing of domestic science. The following technologies and mechanisms for drawing up grant applications, search of international donors, qualitative accompaniment of scientific projects such as project management, fundraising, grant writing, crowdfunding are described. It has been established that grant funding can also be provided within the framework of international technical assistance. It is proved that Ukraine's attraction to the global «grant space» through special financial mechanisms of fundraising and grant writing will contribute to the increase of extrabudgetary revenues to finance research and improvement of material and technical support of certain institutions and organizations, as well as to develop scientific potential, more rational organization of scientific and research achievements, developed system of commercialization of scientific results. In particular, the focus is on the principles of fundraising and grant writing, requirements for professional fundraisers (fundraising managers), grant writers, their qualifications and personalities. We offer peculiarities of training specialists in fundraising and granting through the system of special courses, trainings, seminars, educational institutions, methodologies and educational literature. It is found out that such measures do not guarantee the comprehensiveness and resolution of issues related to high-quality specialists training, as technologies permitted in Ukraine nowadays not in full measure provide an effective public assistance tool due to lack of researches and developments in this area. One of the prospects for fundraising and grant writing development in Ukraine is the need to organize the education of relevant specialists at the university level.
IMPORTÂNCIA DAS FEIRAS LIVRES E SEUS IMPACTOS NA AGRICULTURA FAMILIAR
Authors: Carvalho Francislene de Fátima , Grossi Selma de Fátima 
Published: December 2019

A agricultura familiar tem como objetivo em seu sistema de produção a diversificação de cultura que permite aos produtores a obtenção de alimentos e renda os doze meses do ano. Esse segmento de produção é significativo devido a sua função ambiental, econômica e social tornando-se imprescindível para produtores familiares, pois é por meio desta que ocorre a venda e agregação do valor no produto. Como valor agregado refere-se aos produtos derivados da sua produção original, como doces, verduras lavadas e embaladas, produtos artesanais e utensílios que contribuíram com a renda da família. Os produtores rurais deparam com inúmeras dificuldades nesse elo. Sendo assim, a escolha do canal de distribuição para a venda dos produtos pelos produtores familiares, passa a ser, um fator essencial para a estratégia de comercialização. Nesse contexto, uma das alternativas de comercialização que os produtores familiares estão abraçando são as feiras-livres.
RELAÇÃO ENTRE PERFIL DOCENTE E O DESEMPENHO DISCENTE DOS CURSOS DE CIÊNCIAS CONTÁBEIS
Authors: Pomerening Daniela , Kappel Rodrigo da Silveira 
Published: December 2019

<p>Este artigo tem por objetivo investigar a relação entre o perfil docente e o desempenho discente dos cursos de Ciências Contábeis. A análise da pesquisa foi desenvolvida por meio de evidências quantitativas, obtidas com base em procedimentos estatísticos de regressão linear múltipla. Objetivando maior robustez dos resultados, a avaliação da proposta central demandou a realização de cinco testes empíricos, para avaliar se as características de perfil docente apresentam relação com o desempenho dos alunos, considerando cinco critérios distintos para mensuração da variável de desempenho dos alunos. Além disso, a operacionalização dessa pesquisa demandou o levantamento e análise do perfil de 1.810 professores dos cursos de Ciências Contábeis de 85 Instituições de Ensino Superior da região Sul do Brasil, sendo mensuradas cinco variáveis independentes de perfil docente. Com relação ao desempenho discente, foram utilizados os dados dos resultados no ENADE 2015, Exame de Suficiência do CFC 2017/01, 2017/02, 2018/01 e 2018/02 (CFC, 2017; 2018). </p>
PENGADILAN TINDAK PIDANA KORUPSI DAN TINDAK PIDANA PENCUCIAN UANG
Authors: Subihat Ihat 
Published: December 2019

The act of corruption is a violation of every person’s life as stipulated in Article 28A of the 1945 Constitution. As a result of corruption that has been detrimental to the country’s finance or the country’s economy, it also impedes the growth and sustainability of demanding national development high efficiency. For this corruption case, a court for corruption case has been established. Meanwhile, Money Laundering as stipulated in Law No. 8 of 2010 concerning Prevention and Eradication of Money Laundering Crimes, does not have a special court but is often put together with a court of corruption. A court of corruption is the only court that has the authority to examine, hear, and decide the cases of corruption and money laundering crimes whose original crime is a criminal act of corruption; and/or criminal acts which are explicitly stated in other laws as criminal acts of corruption. The problem is how the litigation of corruption and criminal acts of money laundering are incorporated in an indictment of corruption and money laundering.
This study used the descriptive method with a normative juridical approach. Data collection was carried out through library studies by collecting data in the form of legal materials; primary, secondary and tertiary legal materials. The analysis technique of this study was descriptive analysis that analyze the process and institutions based on legislation.
The results of this study showed that the Corruption Eradication Act regulates materially and formally, so there are exceptions to the principles that are generally regulated in the Criminal Code (KUHP), Criminal Procedure Code (KUHAP) (Lex Specialist Derogate lex Generalis). The modes of money laundering are carried out in various ways. Judging from TPPU modes, it seemed true that TPPU is a stand-alone crime when using cumulative charges is more appropriate. The legal policy of the Corruption Crime Act and Money Laundering Lay (TPPU) related to the rule of law which is the basis of legality for Beneficial Ownership Criminal Liability (BO) as well as its position in Deelneming theory is a topic that must be formulated n the Action Bill Criminal Crime and Money Laundering Crime Bill (TPPU), whether effective evidence for Beneficial Owners (BO), doctrinal or the teaching snares. In the future politics of law enforcement in eradicating corruption and TPPU leads to Beneficial Ownerds (BO) is not enough as long as only the physical actors or stop at the actors revealed in the investigation. Besides the beneficial owner, it is also necessary to regulate criminal liability for legal entities that are used to save the proceeds of money laundering
PERANAN HUKUM DALAM PENGEMBANGAN INDUSTRI PERTAHANAN SEBAGAI INDUSTRI STRATEGIS DIDALAM MENJAGA KEDAULATAN NEGARA KESATUAN REPUBLIK INDONESIA
Authors: Purnamasari Faujura Rahamanisa 
Published: December 2019

Indonesia's geographical located between two continents and oceans, those are the Asian nd the Australian Continent, and the Indian and the Pacific Ocean, has made Indonesia to become a country with strategic position, both for the world trade route and inter-State relations. But on the other hand Indonesia has the sovereignty of the State that must be guarded and maintained from all kinds of threats both from within and outside. For this reason, Indonesia is required to have the capacity in the form of TNI defense equipment, which is adequate as the main instrument to protect territorial sovereignty and to safeguard national interests from the threats, challenges, obstacles and disturbances both from domestic and foreign. Therefore, the development of the defense industry is also needed. The main problem in this study is how does the law regulate the development of defense industry as Indonesia's strategic industry?The descriptive method of analysis with normative juridical was used in analyzing the problems of the development of the defense industry in facing the challenges, threats, and disruptions to the Republic of Indonesia's sovereignty as a consequence of the strategic location of Indonesia's geographical position.
The results of the study show that the defense industry has a position as a strategic industry, because the primary weaponry defense system has important role in order to maintain the sovereignty of the State. Even though the regulation has been assigned in a law, namely Law Number 16 of 2012 concerning on the Defense Industry, but it has not been regulated by clear regulations and is tend to ad hoc, which is certainly not beneficial for the growth and development of the National defense industry. Law as a medium of renewing society must be able to make changes, so that it can direct where the national defense industry will be developed, so it is able to create companies that are reliable in producing defense equipment to preserve national sovereignty.
Potensi Perlindungan Terhadap Ilmu Pengetahuan dan Teknologi oleh Dosen di Perguruan Tinggi dalam Peningkatan Daya Saing Global
Authors: Sudjana Sudjana 
Published: December 2019

This study discusses the potential of Intellectual Property protection on the creation of Science and Technology Development results by Lecturers in Higher Education and Intellectual Property Protection on the Creation of Science and Technology Development results in Universities in Improving Global Competitiveness.This study is a legal research using a normative juridical approach and descriptive analytical research specifications. The data used in this study are secondary data consisting of primary, secondary and tertiary legal materials. Data obtained through library studies and field research in the form of legislation, books, journals, and authoritative electronic media.
The results of the study show that (1). the results of Science and Technology Development by university lecturers have the potential to obtain wealth protection in the field of Copyright and Patents, but do not rule out rights through other types of Intellectual Property. (2). Creation of Science and Technology development results that are protected by Intellectual Property and supported by the value chain and competitive scope will have high quality and reputation so as to enhance global competitiveness.
ARAH PEMBAHARUAN HUKUM NASIONAL DALAM MENGHADAPI ERA REVOLUSI INDUSTRI 4.0
Authors: Suratno Ujang 
Published: December 2019

Indonesia has some varieties of ethnic groups that are rich in diversity of intellectual property, there are so many products produced by society. The society creations especially created by the community are assorted, one of them is Paoman Batik. Thre are two kinds of Paoman Batik, those are contemporary and traditional, which is distinguished by its motives, processes, creators. The Paoman Traditional Batik is well-known to the public than contemporary. This research has supported the creators or copyright holders to get higher benefits, both the benefits of moral and economic rights. The main problem is, first, is the current intellectual property rights regime able to provide the foundation for the protection of Paoman Traditional Batik? Second, is the UNESCO's determination that stated if batik is a world heritage, non-object from Indonesia, can be used as the foundation to charge the economic rights of Paoman Traditional Batik? Third, is it possible for Traditional Batik, including Paoman Traditional Batik, to be carried out through other regimes, in addition to the intellectual property regime? Fourth, how is the effect of Paoman Traditional Batik Registered at the Directorate General of Intellectual Property of Indonesia on the Progress of Indramayu society?
The research method used is descriptive specification, by using juridical empirical approach, which focus on secondary research consisting of legal materials, both primary, secondary and tertiary. However it is supported by primary data generated from field research through in-depth interview and survey techniques. The analysis used is descriptive analysis.
The results of the study show that intellectual property rights that is copyright cannot be made as the foundation of protection against the creation of society that have traditional and communal motives, including the Paoman Tradsional Batik. The establishment of Batik by UNESCO as a non-object world heritage from Indonesia has increased the moral rights of Indonesia, but it also cannot be established as the foundation for restoring economic rights when there is a misappropriation. Another alternative to intellectual property is through the Sui Generis regime, which specifically addresses the protection of community rights, including intellectual property rights.
Global Behavior of Two Rational Third Order Difference Equations
Authors: ABO-ZEİD R. , KAMAL H. 
Published: December 2019

In this paper, we solve and study the global behavior of all admissible solutions of the two difference equations $$x_{n+1}=\frac{x_{n}x_{n-2}}{x_{n-1}-x_{n-2}}, \quad n=0,1,...,$$ and $$x_{n+1}=\frac{x_{n}x_{n-2}}{-x_{n-1}+x_{n-2}}, \quad n=0,1,...,$$ where the initial values $x_{-2}$, $x_{-1}$, $x_{0}$ are real numbers.\\ We show that every admissible solution for the first equation converges to zero. For the other equation, we show that every admissible solution is periodic with prime period six. Finally we give some illustrative examples.
Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB4 leukemia cells via down-regulation of BIRC5 expression
Authors: Dehghan Nayeri M.J. , Mahdavi M. , Fazeli H. , Hosseinpour Feizi M.A. 
Published: December 2019

Summary. Aim: It has been reported that spiroaminopyrimidine derivatives inhibited the growth and proliferation of various cancer cell lines. In the present study, we evaluated cytotoxic and apoptosis-inducing effects of 2,4-diamino-1,3-diazaspiro[5.5]-9-tert-butyl-2, 4-diene-5-carbonitril (9-tBAP) on NB4 acute promyelocytic leukemia (APL) cells. Materials and Methods: The cells were treated with 10–100 µM of 9-tBAP. Cytotoxic activity of the compound was measured using the MTT assay. Apoptosis was investigated by Hoechst 33258 staining as well as by Annexin V/PI double staining. Results: The compound under study was found to be highly active cell growth inhibitor with IC50 of 30.0 ± 3.5 µM inducing apoptosis in NB4 cells. Cell cycle analysis by flow cytometry showed a time-dependent increase in sub-G1 cell population. Real-time polymerase chain reaction analysis revealed that the treatment with the compound down-regulated the BIRC5 expression in a time-dependent manner. Conclusion: 9-tBAP displayed potent anti-leukemic activity in vitro thus warranting further investigation.
Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer
Authors: Burlaka A.P. , Burlaka А.А. , Virko S.V. , Ganusevich І. І. 
Published: December 2019

Summary. Background: Interaction between tumor cells and tumor microenvironment is critical for homeostasis of normal cells and tumor growth. Tumor cell — stroma interaction represents the potent factor able to initiate cancer and affect tumor progression and disease outcome. The tumors vary by their origin and microenvironment (proportion of stromal cells, their composition and activation state). The surgical stress and tumor microenvironment may potentiate acute hepatic failure in the patients with metastatic colorectal cancer (mCRC). Pathological effect of ischemia-reperfusion (I/R) consists in the increased generation of superoxide radicals (SR) and nitrogen oxide (NO) affecting the postresectional regeneration of liver tissue. Redox state of hepatic tissue in I/R setting upon resection of metastases may trigger the aggressiveness of residual cancer cells and regeneration or degradation of hepatic tissue. The aim of the study was to analyze redox state of hepatic tissue following surgery with Pringle maneuver (PM) in the patients with mCRC. Materials and Methods: mCRC samples from 145 patients treated at National Cancer Institute, Ministry of Health of Ukraine, were analyzed. The patients obtained chemotherapy according to the approved international and national standards as well as clinical protocols. Two groups of patients were delineated according to the duration of the interruption of blood inflow due to PM, namely ≤ 45 min and > 45 min. The activity of FeS proteins in the electron transport chain (ETC) in mitochondria and lactoferrin (LF) level in the tissues were assessed by EPR (77К). The rates of SR and NO generation were determined with spin traps. The activity of matrix metalloproteinase (MMP)-2 and -9 was measured by gelatin zymography using SDS-polyacrylamide gel electrophoresis. Results: In tissue of liver resected in the setting of > 45 min ischemia, ETC function in mitochondria was impaired (decreased activity of FeS protein of N-2 ETC complex I due to interaction with NO). This results in the hypoxia state and glycolysis with uncontrolled SR generation. In addition, the efficiency of detoxification system in hepatocytes is reduced substantially with increase in semiquinone and LF levels as well as MMP-2 and -9 activity as compared with liver without metastatic lesions that was not affected by I/R. Conclusions: The ischemic injury of liver in the setting of metastasis resection results from cell response to interruption of blood flow followed by reperfusion. The key factor in the genesis of reperfusion damage is uncontrolled increase of the levels of SR and their metabolites — reactive oxygen species as well as the increased MMP activity. Also, liver tissue affected by I/R contains high levels of xanthine oxidase metabolizing hypoxanthine and monoamine oxidase deaminizing biogenic amines. Both processes are the sources of SR.
Association between XPO5 rs11077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 8511 controls
Authors: Moazeni-Roodi A. , Taheri M. , Hashemi M. 
Published: December 2019

Summary. Aim: Several studies evaluated the association between rs11077 polymorphism located in the 3’UTR of the XPO5 gene and cancer susceptibility. We conducted a meta-analysis to assess the impact of XPO5 rs11077 polymorphism on cancer risk. Materials and Methods: The online databases were searched for relevant case-control studies published up to July 2018. 15 articles of 16 studies, with totally 7284 cancer cases and 8511 healthy controls, were eligible for inclusion in the meta-analysis. The data were extracted from the eligible studies and were processed using Stata 14.1 and Revman 5.3 software. Pooled estimates of odds ratio with 95% confidence intervals were used to evaluate the strength of association between XPO5 rs11077 and cancer risk. Results: Overall, our finding showed no significant association between XPO5 rs11077 variant and overall cancer risk, either performed subgroup analysis by cancer types and ethnic groups in all genetic model. Conclusion: The findings did not support an association between rs11077 variant and cancer risk. Due to small sample sizes particularly in stratified analysis, further large-scale well designed studies between this polymorphism and cancer risk are warranted.
Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392
Authors: Woksepp H. , Saini R.K.R. , Zakharchenko O. , Gautier A. , Souchelnytskyi N. , Souchelnytskyi S. 
Published: December 2019

Summary. Aim: Transforming growth factor β1 (TGF β1) is a potent regulator of breast tumorigenesis. It inhibits proliferation of carcinoma cells, but the strength of its inhibitory action varies for cells from benigh, non-metastatic or metastatic tumors. The aim of this work was to generate a proteome profile of TGF β1 action on non-tumorigenic human breast epithelial cells 184A1, and validate predicted involvement of casein kinase 2α (CK2α), p53 and structure-specific recognition protein-1 (SSRP1). Materials and Methods: Two-dimensional gel electrophoresis and mass spectrometry were used to identify TGF β1-regulated proteins in 184A1 human breast immortalized non-tumorigenic cells. 184A1 cells may serve as a model of benign breast neoplasia. These cells were obtained from normal mammary tissue, were immortalized but are not malignant, and were obtained from the American Type Culture Collection. The systemic analysis was performed by using the Cytoscape tool. Transfection of cells with CK2α construct and small interfering RNAs to CK2α and SSRP1 were used to assess an impact of CK2α and SSRP1 on phosphorylation of the p53 and cell proliferation. Results: Proliferation of 184A1 cells was transiently inhibited by TGF β1. We identified 100 and 47 unique proteins which changed their expression and/or 35S-incorporation, respectively, upon treatment with TGF β1 for 2 h, 8 h or 24 h. Cell proliferation, death, migration, and metabolism were among the biological regulatory processes retrieved by the network analysis as affected by the identified proteins. The network analysis suggested that TGF β1 may affect the phosphorylation of p53 at Ser392 by engaging CK2α. This was confirmed by the immunoblotting and cell proliferation assays. Conclusion: We report here the list of 147 TGF β1-regulated proteins in immortalized non-tumorigenic human breast epithelial cells, and show involvement of CK2α in the regulation of p53 Ser392 phosphorylation.
Efectos de la capacitación y la retroalimentación sobre el plagio académico en estudiantes de Bachillerato
Authors: Arce Dariel Diaz , Brito González José Luis , Nieto Trelles Valeria Alexandra , Muñoz Arévalo Wilson David 
Published: December 2019

El plagio académico es un problema que afecta a estudiantes de todos los niveles de enseñanza. El presente trabajo tuvo como objetivo evaluar la utilidad de un programa de capacitación y retroalimentación sobre la disminución del plagio académico en estudiantes de bachillerato. Se diseñó un estudio cuasiexperimental con una muestra de 61 estudiantes de bachillerato. Se establecieron sesiones de capacitación al inicio del año lectivo y posteriormente se recibieron durante el año cuatro trabajos académicos, cada uno de los cuales fue retroalimentado y evaluado para detectar diferentes formas de plagio, el nivel de gravedad y las mejorías observadas. Los resultados muestran una tendencia a reducir la frecuencia de formas graves de plagio hacia el final del estudio. El 44,3% mostró signos claros de mejoría en la comprensión y aplicación de la citación y referenciado de fuentes y otro 29,5% se mantuvo sin ninguna forma de plagio desde el inicio del curso. Hubo diferencias significativas en las mejorías observadas dependiendo del sexo y el rendimiento académico. Se concluye que la estrategia planteada puede ayudar a disminuir la frecuencia de plagio académico entre los estudiantes de bachillerato. Se recomiendas nuevos estudios experimentales en los que se puedan controlar más variables y observar la fortaleza de la propuesta.