bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile-Heutagogical Practices among Student Teachers: Its Pedagogical Affordances and Challenges
Authors: Wong Kung-Teck , Muhammad Mazura @ Mastura Binti , Abdullah Norazilawati Binti , Hamdan Analisa 
Published: February 2020

The integration of Information and Communication Technology (ICT) in the classroom for learning is becoming important to improve student engagement and interaction. This is in line with the educational transformation towards achieving Higher Education 4.0 in Malaysia. Education 4.0 (Edu 4.0) is in line with the Industrial Revolution 4.0 (4IR) and underpin the Malaysia Education Blueprint 2015-2025. There has been a recent surge in published studies on Mobile-Heutagogy (M-Heutagogy), with most studies has been conducted in developed countries, where the outcomes of the studies have revealed that M-Heutagogy has significant impacts on Edu. 4.0. Against this backdrop, this paper aims to discuss the M-Heutagogy pedagogical affordances of such a tool, the challenges that it poses, and the pedagogical change that is entailed for the adoption of the M-Heutagogy in the classroom. As a preliminary investigation in Malaysia, this study was carried out based on the phenomenological perspective of selected student teachers concerning the above affordances and challenges of M-Heutagogy through interviews. It was revealed that the use of such a novel learning tool helped spur their students’ interest, stimulate their curiosity, and improve their confidence in learning scientific concepts. In particular, the use of M-Huetagogy has proven can help to improve student participation in the learning process through more intense discussions among student teachers, which led to an improved understanding of learning concepts. However, the main barriers to full integration of such a tool in teaching and learning were attributed to the lack of technical support, teaching skills and confidence, and suitable facilities.
Investigating the Semantic Development of Modal Markers: The Role of Context
Authors: Potočnik Tomaž , Hriberšek Matej 
Published: February 2020

The article tackles the problem of studying diachronic semantic changes of modal markers in Latin. It proposes to do so by using context as a proxy for tracing the development of otherwise unchanging forms. In the first part, the main theoretical positions in modality studies are presented, especially the notions of deontic modality, epistemic modality, and pathways of modality. In the second part, Heine’s model for studying the role of context in language change is presented and applied to the modal verb licet. In the case study of licet, an attempt is made to identify the so-called switch context which co-creates the conditions necessary for the semantic change.
Multi-scale data on intertidal macrobenthic biodiversity and environmental features in three New Zealand harbours
Authors: Kraan Casper , Greenfield Barry L. , Thrush Simon F. 
Published: February 2020

Abstract. Understanding how the plants and animals that live in the
sea floor vary in their spatial patterns of diversity and abundance is
fundamental to gaining insight into the role of biodiversity in maintaining
ecosystem functioning in coastal ecosystems, as well as advancing the
modelling of species distributions under realistic assumptions. Yet, it is
virtually unknown how the relationships between abundance patterns and
different biotic and environmental processes change depending on spatial
scales, which is mainly due to a lack of data. Within the project Spatial
Organization of Species Distributions: Hierarchical and Scale-Dependent
Patterns and Processes in Coastal Seascapes at the National Institute for
Water and Atmospheric Research (NIWA) in New Zealand we collected
multi-scale and high-resolution data on macrobenthic biodiversity. We found
146 species dominated by bivalves, polychaetes, and crustaceans
(>500 µm) that live hidden in marine sandflats and
collected point measurements of important environmental variables (sediment
grain-size distributions, chlorophyll a concentration, organic content, and
visible sandflat parameters) in three large intertidal harbours (Kaipara,
Tauranga, and Manukau). In each harbour we sampled 400 points for
macrobenthic community composition and abundances, as well as the full set
of environmental variables. Using an elaborate sampling design, we were able
to cover scales from 30  cm to a maximal extent of 1 km. All data
and extensive metadata are available from the data publisher PANGAEA via the
persistent identifier https://doi.org/10.1594/PANGAEA.903448 (Kraan et al.,
2019).
Standardised soil profile data to support global mapping and modelling (WoSIS snapshot 2019)
Authors: Batjes Niels H. , Ribeiro Eloi , van Oostrum Ad 
Published: February 2020

Abstract. The World Soil Information Service (WoSIS) provides
quality-assessed and standardised soil profile data to support digital soil
mapping and environmental applications at broadscale levels. Since the
release of the first “WoSIS snapshot”, in July 2016, many new soil data were
shared with us, registered in the ISRIC data repository and subsequently
standardised in accordance with the licences specified by the data
providers. Soil profile data managed in WoSIS were contributed by a wide
range of data providers; therefore, special attention was paid to measures
for soil data quality and the standardisation of soil property definitions,
soil property values (and units of measurement) and soil analytical method
descriptions. We presently consider the following soil chemical properties:
organic carbon, total carbon, total carbonate equivalent, total nitrogen,
phosphorus (extractable P, total P and P retention), soil pH, cation
exchange capacity and electrical conductivity. We also consider the following physical properties:
soil texture (sand, silt, and clay), bulk density, coarse fragments and
water retention. Both of these sets of properties are grouped according to analytical procedures that are
operationally comparable. Further, for each profile we provide the original
soil classification (FAO, WRB, USDA), version and horizon designations,
insofar as these have been specified in the source databases. Measures for
geographical accuracy (i.e. location) of the point data, as well as a first
approximation for the uncertainty associated with the operationally defined
analytical methods, are presented for possible consideration in digital soil
mapping and subsequent earth system modelling. The latest (dynamic) set of
quality-assessed and standardised data, called “wosis_latest”, is freely accessible via an OGC-compliant WFS (web feature
service). For consistent referencing, we also provide time-specific static
“snapshots”. The present snapshot (September 2019) is comprised of 196 498
geo-referenced profiles originating from 173 countries. They represent over
832 000 soil layers (or horizons) and over 5.8 million records. The actual
number of observations for each property varies (greatly) between profiles
and with depth, generally depending on the objectives of the initial
soil sampling programmes. In the coming years, we aim to fill gradually gaps
in the geographic distribution and soil property data themselves, this
subject to the sharing of a wider selection of soil profile data for so far
under-represented areas and properties by our existing and prospective
partners. Part of this work is foreseen in conjunction within the Global
Soil Information System (GloSIS) being developed by the Global Soil
Partnership (GSP). The “WoSIS snapshot – September 2019” is archived and
freely accessible at https://doi.org/10.17027/isric-wdcsoils.20190901
(Batjes et al., 2019).
“A WeeklyMäshräpto Tackle Extremism”: Music-Making in Uyghur Communities and Intangible Cultural Heritage in China
Authors: Harris Rachel 
Published: February 2020

AbstractThis article provides an in-depth study and critique of the nomination and inscription of an item on UNESCO’s lists of intangible cultural heritage and the developments following its acceptance. China is now a major partner in UNESCO’s heritage projects, but the application and experience of heritage initiatives across China have been highly uneven. I discuss the particular challenges presented in the contested, predominantly Muslim Xinjiang Uyghur Autonomous Region. I focus on the question of community, a term that lies at the heart of the UNESCO literature. What do we mean by community, and why do we think it matters? How does socially embedded music-making facilitate community, and how do heritage initiatives change that?مهزكۇر ماقاله تهنقﯩدﯨي مهۋقهده تۇرۇپ، بﯩر غهيرى رهسمﯩي مهدهنﯩيهت مﯩراسﯩنﯩڭ بﯩرلهشكهن دۆلهتلهر تهشكﯩلاتى پهن مهدهنﯩيهت مهھكﯩمﯩسﯩگه قانداق قﯩلﯩپ نامزاتلﯩققا كۆرسﯩتﯩلگهنلﯩكى ۋه ئهنگه ئېلﯩنغانلﯩقى، ھهم بۇ مهدهنﯩيهت مﯩراسى قوبۇل قﯩلﯩنغاندﯨن كېيﯩنكى تهرهققﯩيات ئهھۋاللﯩرى قاتارلﯩق مهسﯩلﯩلهر ئۈستﯩده ئېلﯩپ بېرﯨلغان ئﯩنچﯩكه تهتقﯩقات مهزمۇنلﯩرى بﯩلهن تهمﯩنلهيدۇ. گهرچه خﯩتاي ھۆكۈمﯩتى ھازﯨر بﯩرلهشكهن دۆلهتلهر تهشكﯩلاتى پهن مهدهنﯩيهت مهھكﯩمﯩسﯩنﯩڭ مهدهنﯩي مﯩراسلارنى قوغداش ئﯩش تۈرلﯩرﯨگه ئهڭ كوپ ئﯩقتﯩسادﯨي ياردهم بېرﯨدﯨغان دۆلهت بولسﯩمۇ ئهمما خﯩتاي دۆلﯩتﯩده مهدهنﯩيهت مﯩراسلﯩرﯨنى قوغداشقا ئﯩلتﯩماس قﯩلﯩش ۋه ئۇنﯩڭدﯨن كېيﯩنكى خﯩزمهتلهرنﯩڭ ئﯩجرا قﯩلﯩنﯩشى ئﯩنتايﯩن تهڭپۇڭسﯩز. مهن مۇشۇ تېمﯩنى چۆرﯨدﯨگهن ھالدا، بولۇپمۇ مۇسۇلمانلار مۇتلهق كۆپ سانلﯩقنى ئﯩگهللهيدﯨغان شﯩنجاڭ ئۇيغۇر ئاپتونوم رايونﯩدﯨكى مهۋجۇت مهسﯩلﯩلهر ھهققﯩده مۇنازﯨره ئېلﯩپ بارﯨمهن. مهن، بۇ يهردﯨكى جهمﯩيهتته بولۇۋاتقان مهسﯩلﯩلهرنى ھالقﯩلﯩق نۇقتا قﯩلﯩپ تۇرۇپ، بﯩرلهشكهن دۆلهتلهر تهشكﯩلاتى پهن مهدهنﯩيهت مهھكﯩمﯩسﯩنﯩڭ ئﯩچﯩده قانچﯩلﯩك ساختﯩلﯩقلارنﯩڭ بولۇۋاتقانلﯩقﯩنى ئوتتۇرﯨغا قويﯩمهن. بۇ ئهھۋاللار ئۇيغۇر جهمئﯩيﯩتى تهرﯨپﯩدﯨن قانداق چۈشﯩنﯩلﯩدۇ ۋه بﯩز نﯩمﯩشقا بۇ ئﯩشنى ناھايﯩتى ئېغﯩر مهسﯩله دهپ قارايمﯩز؟ مهدهنﯩيهت مﯩراسلﯩرﯨغا ۋارﯨسلﯩق قﯩلﯩش خﯩزمهتلﯩرى شۇ جهمئﯩيهتنﯩڭ ئﯩجتﯩمائﯩي ساھهسى بﯩلهن زﯨچ باغلﯩنﯩشلﯩق بولغان مۇزﯨكا ئﯩشلهپچﯩقﯩرﯨشﯩغا قانداق ئۆزگﯩرﯨشلهرنى ئېلﯩپ كېلﯩدۇ؟
An Independent Validation of the Brighton Spondylodiscitis Score and a Proposal to Modify the Score
Authors: Urrutia Julio , Besa Pablo , Meissner-Haecker Arturo , Delgado Byron 
Published: February 2020

Introduction:
The Brighton Spondylodiscitis Score (BSS) aims to identify patients with pyogenic spinal infections (PSIs) requiring surgery; an independent assessment of the BSS is required.

Methods:
We evaluated 60 patients with PSIs. Using the BSS, we determined whether patients with low, moderate, and high risk (LMHR) had different rates of surgery. We proposed a modified score (MS) using a logistic regression (LOGR). Applying the MS, we determined whether patients with LMHR exhibited different rates of surgery. Another LOGR determined the association of the BSS and the MS with surgery. A C-statistic using the BSS and the MS was generated.

Results:
We studied 60 patients (mean age = 63 years); 37 (62%) were men; 30 (50%) required surgery. Using the BSS, patients with LMHR had similar rates of surgery (P = 0.53). LOGR showed that cervical PSIs had a larger chance of surgery (odds ratio [OR] = 7.3 [1.1 to 51.3]) than other locations. Using the MS, patients with moderate- and high-risk were operated more frequently than low-risk patients (P = 0.04). The BSS did not predict surgery (OR = 1.07; P = 0.31), but the MS did (OR = 1.16; P = 0.02). The C-statistic using the BSS (0.59) improved using the MS (0.69), P = 0.03.

Discussion:
The discriminatory capacity to predict surgery of the BSS augmented using the MS.

Level of Evidence:
II (Diagnostic study: Transverse study)
In beroep tegen visumweigering: een bespreking van het Hof van Justitie-arrest Vethanayagam
Authors: Klaassen M.A.K. 
Published: February 2020

In beroep tegen visumweigering: een bespreking van het Hof van Justitie-arrest Vethanayagam
In de uitspraak Vethanayagam oordeelt het Hof van Justitie dat een vreemdeling alleen beroep in kan stellen tegen de weigering van een visum in de staat die op grond van een bilaterale vertegenwoordigingsregeling ertoe is gemachtigd om een beslissing te nemen op de visumaanvraag. Dit levert volgens het Hof van Justitie geen spanning op met het recht op effectieve rechterlijke bescherming. In de onderhavige zaak konden de betrokken vreemdelingen in beroep gaan tegen de visumweigering in Zwitserland. In deze bespreking wordt ingegaan op praktische aspecten die afbreuk kunnen doen aan de doeltreffendheid van effectieve rechterlijke toetsing door de vertegenwoordigende lidstaat en de positie van Zwitserland als niet-EU-lidstaat.HvJ 29 juli 2019, zaak C-680/17, ECLI:EU:C:2019:627, JV 2019/158, m.nt. Boeles (Vethanayagam e.a.)
Conversación
Authors: Peñín Llobell Alberto , Felip Olga , Gascón Eduardo , Godó Ramon , Leclerc Judith , Mejón Artigas Julio José , Partida Muñoz Mara Gabriela 
Published: February 2020

Conversación entre los 7 actuales profesores de la Cátedra Blanca: Olga Felip, Eduard Gascón, Ramón Godó, Judith Leclerc, Julio Mejón, Mara Partida
Barcelona, June 11, 2019; under the pretext of Ramón Godo’s last day of class at the School, the seven professors of the White Chair of Barcelona gathered around a table. The course ends and with the first heats of summer the chair (on its 20th anniversary) has to face new challenges such as its passage to the ETSAB master’s degree, after 13 courses in the third year of the career. The atmosphere of change, after a long sweet and fruitful period, is the ideal context to discuss two or three questions, about our origins, our concerns, about the future of students, the profession and the School.
MARKETING MANAGEMENT OF THE LIGHTHOUSE HERITAGE IN THE FUNCTION OF STRENGTHENING THE NATIONAL IDENTITY ON THE GLOBAL TOURISM MARKET: STONE LIGHTS (CROATIA) AND THE ART OF THE LIGHTHOUSES (MONTENEGRO)
Authors: Jakšić Stojanović Anđela , Šerić Neven , Perišić Mate 
Published: February 2020

The paper presents marketing projects of managing lighthouses as cultural and historical heritage in Croatia and Montenegro. Regardless of the advances in technology and changes of the functioning of modern navigational aids, lighthouses as cultural-historical monuments can get other value through the touristic market. The Croatian Stone Lights project is a commercialization of lighthouse buildings as a good practice example of promoting the maritime identity of the country, promoting national tourism offer and positioning the national tourism brand in the global tourism market. The Montenegrin project The Art of the Lighthouses is an original concept of creating destination icons by implementing art installations on lighthouses, harbours and coastal lights, which were used in this project for a purpose other than their primary one – being part of the navigation safety system. The aim of the paper is to present the results of these projects and their impact on the national identity. There are few tourist destinations in the world that offer accommodation in lighthouses, and there are still fewer examples of using port and coastal lights as recognizable destination icons. The paper develops through three basic sections: the introduction of both projects, descriptive analysis of tourist valorisation of lighthouses (marketing management of lighthouses as a part of cultural heritage and creation of destination icons), and finally research findings (focus of tourism expert groups – how to connect Croatian and Montenegrin projects on the marketing platform). The research results of this paper aim at linking Croatian and Montenegrin marketing experiences for the possible future cooperation in the field of commercialization of cultural and historical resources for touristic valorisation.
Early changes in the urine proteome in a rat liver tumour model
Authors: Zhang Yameng , Gao Yufei , Gao Youhe 
Published: February 2020

Background
Urine, as a potential biomarker source among body fluids, can accumulate many early changes in the body due to the lack of mechanisms to maintain a homeostatic state. This study aims to detect early changes in the urinary proteome in a rat liver tumour model.

Methods
The tumour model was established with the Walker-256 carcinosarcoma cell line (W256). Urinary proteins at days 3, 5, 7 and 11 were profiled by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Compared with controls, differential proteins were selected. Associations of differential proteins with cancer were retrieved.

Results
At days 3, 5, 7 and 11, five, fifteen, eleven and twelve differential proteins were identified, respectively. Some of the differential proteins were reported to be associated with liver cancer. This differential urinary protein pattern was different from the patterns in W256 subcutaneous, lung metastasis and intracerebral tumour models.

Conclusions
This study demonstrates that (1) early changes in urinary proteins can be found in the rat liver tumour model; (2) urinary proteins can be used to differentiate the same tumour cells grown in different organs.
Prospective observational study of FKRP‐related limb‐girdle muscular dystrophy R9: A GRASP consortium study
Authors: Alfano Lindsay N. , James Meredith K. , Grosfjeld Petersen Kristine , Rudolf Karen , Vissing John , Augsburger Renee , Mozaffar Tahseen , Jones Aileen , Butler Amanda , Laubscher Katie M. , Mockler Shelley R. H. , Mathews Katherine D. , Iammarino Megan A. , Reash Natalie F. , Pietruszewski Lindsay , Lowes Linda P. , Strahler Talia , Wicklund Matthew , Hunn Stephanie , Weihl Conrad C. , Sasidharan Sandhya , Currence Melissa , Statland Jeffrey M. , Stinson Nikia , Holzer Megan , Leung Doris G. , Lott Donovan J. , Kang Peter B. , Holsten Scott , Desai Urvi , Johnson Nicholas E. ,   the GRASP‐LGMD Consortium
Published: December 2024

AbstractObjectiveLimb‐girdle muscular dystrophy R9 (LGMDR9, formerly known as LGMD2I), caused by variants in the fukutin‐related protein (FKRP) gene leads to progressive muscle weakness of the shoulder and pelvic limb‐girdles and loss of motor function over time. Clinical management and future trial design are improved by determining which standardized clinical outcome assessments (COA) of function are most appropriate to capture disease presentation and progression, informing endpoint selection and enrollment criteria. The purpose of our study was to evaluate the cross‐sectional validity and reliability of clinical outcome assessments in patients with FKRP‐related LGMDR9 participating in the Genetic Resolution and Assessments Solving Phenotypes in LGMD (GRASP) natural history study.MethodsEnrolled patients completed a battery of COA on two consecutive days, including the North Star Assessment for limb girdle‐type dystrophies (NSAD), the 100‐m timed test (100 m), and the Performance of Upper Limb 2.0 (PUL).ResultsA total of 101 patients with FKRP‐related LGMDR9 completed COA evaluations. All functional COA were highly and significantly correlated even across constructs, except for the 9‐hole peg test. Similarly, all tests demonstrated excellent test–retest reliability across 2‐day visits. The NSAD and PUL demonstrate robust psychometrics with good targeting, ordered response thresholds, fit and stability, and limited dependency of items across the scales.ConclusionsThis study has determined the suitability of several functional COA, cross‐sectionally, in LGMDR9 to inform future trial design and clinical care.
Skull defect – Frontotemporal dementia sagging brain syndrome
Authors: Schievink Wouter I. , Maya Marcel M. , Babadjouni Robin , Tay Angelique Sao‐Mai S. , Taché Rachelle B. 
Published: December 2024

AbstractObjectiveFrontotemporal dementia (FTD) sagging brain syndrome is a disabling condition. An underlying spinal Cerebrospinal fluid leak can be identified in only a minority of patients and the success rate of non‐directed treatments is low. Some of these patients have a remote history of craniectomy/cranioplasty and we report a positive response to custom implant cranioplasty revision many years after their initial cranioplasty.MethodsWe reviewed medical records and imaging studies of 61 consecutive patients with FTD sagging brain syndrome. A SIH Disability Assessment Score (SIHDAS) questionnaire was completed to assess the severity of the symptoms before and after custom implant cranioplasty. Pre‐ and post‐operative brain MRI was obtained to assess degree of brain sagging.ResultsEight (13.1%) of the 61 patients had a history of craniectomy/cranioplasty 1.5–13.5 years prior to onset of symptoms of FTD sagging brain syndrome. The mean age of the one woman and seven men at the time of presentation to our medical center was 50 years (range, 26–68 years). None had sinking scalp flap syndrome. Prior treatments included epidural blood patching and dural reduction surgery. Custom cranial implant surgery was performed in four patients and resulted in prompt and remarkable improvement of symptoms in three patients (SIHDAS: very severe disability to no or mild disability) and mild improvement in one patient. Brain MRI showed improvement of brain sagging.InterpretationA disproportionate number of patients with FTD sagging brain syndrome have a remote history of supratentorial craniectomy/cranioplasty and revision cranioplasty should be considered.
Argatroban plus alteplase in posterior versus anterior circulation stroke
Authors: Cui Yu , Chen Hui‐Sheng 
Published: December 2024

AbstractObjectiveARAIS trial failed to demonstrate benefit of argatroban as an adjunct to alteplase for stroke. Given differences between anterior circulation stroke (ACS) and posterior circulation stroke (PCS), we performed prespecified secondary analysis to investigate whether benefit of argatroban was different between ACS and PCS.MethodsIn secondary analysis of ARAIS, patients with definite stroke territories based on responsible vessel examination were classified into ACS and PCS. The primary outcome was a 90‐day excellent functional outcome (modified Rankin Scale score of 0 to 1). The efficacy was compared between argatroban plus alteplase and alteplase alone.ResultsThis study included 356 patients from the full analysis set of ARAIS trial: 283 in the ACS group and 73 in the PCS group. Compared with alteplase alone, a higher likelihood of 90‐day excellent functional outcome was associated with argatroban plus alteplase in PCS group (78.1% versus 61.0%; adjusted RD, 14.4%; 95% CI, 1.6% to 27.2%; p = 0.03), but similar in ACS group (61.7% versus 62.7%; adjusted RD, −2.4%; 95% CI, −10.1% to 5.2%; p = 0.54). After controlling unbalanced sample size bias by propensity score matching, significant interaction between efficacy and stroke territories was found (p = 0.01). The risk of symptomatic intracranial hemorrhage was higher following argatroban plus alteplase than alteplase alone in ACS group (p = 0.02).InterpretationArgatroban plus alteplase, compared with alteplase alone, was associated with improved functional outcomes in PCS. This study first demonstrated better benefits of argatroban plus alteplase in PCS, which deserves to be confirmed.