bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF DIACEREIN FOR ENHANCED DISSOLUTION RATE
Authors: TAMBOLI JAMEER A , K MOHITE SHRINIVAS 
Published: October 2019

Objective: The objective of the present study was to develop solid self-microemulsifying drug delivery system (S-SMEDDS) of diacerein (DCN) for enhancement of dissolution rate.
Methods: Three batches of liquid SMEDDS were prepared using oleic acid, Tween 80, and polyethylene glycol 200 as oil, surfactant, and cosurfactant, respectively. Microemulsion region was recognized by constructing a pseudoternary phase diagram containing a different proportion of oil, surfactant, and cosurfactant. Prepared liquid SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size, zeta potential, and viscosity. Liquid SMEDDS was then converted to S-SMEDDS by adsorption technique using Neusilin US2 as a solid carrier. Prepared S-SMEDDS was evaluated for different micromeritic properties, drug content, reconstitution properties, in vitro dissolution study, Fourier transform infrared, and scanning electron microscopy.
Results: The results showed that all batches of liquid SMEDDS were found to be thermodynamically stable. Reconstitution properties of S-SMEDDS showed spontaneous microemulsification with globule size 0.271 μm and −16.18 mV zeta potential. From the results of in vitro dissolution study, it was found that the release of DCN was significantly increased as compared with plain DCN.
Conclusion: The study concluded that dissolution rate of poorly water-soluble drug like DCN can be increased by developing S-SMEDDS formulation.
ANTIOXIDANT, ANTIBACTERIAL, AND ANTICANCER ACTIVITY FROM MARINE RED ALGAE GRACILARIA EDULIS.
Authors: TS HEMASUDHA , R THIRUCHELVI , P BALASHANMUGAM 
Published: October 2019

Objective: The marine seaweed Gracilaria edulis was collected from Rameshwaram Mandapam coast. The main objective of G. edulis was to check about the antioxidant, antibacterial, and anticancer activity. The potential use of seaweeds is to prevent colon cancer and leukemia. The crude extract of antioxidant activity was done in methanol and aqueous extract in various concentrations using DPPH assay. The antibacterial activity was analyzed in methanol extract. The antibacterial activity was tested in Gram-positive bacteria (Staphylococcus aureus) and Gram-negative (Pseudomonas) bacteria with various concentration. The anticancer activity was tested against using the breast cancer cell line (MDA-MB231)
Methods: The antibacterial activity was checked by crude methanol extract using Gram-positive bacteria (S. aureus) and Gram-negative bacteria (Pseudomonas) with different concentrations. The antioxidant activity was determined using DPPH radical scavenging assay in various concentrations. The anticancer activity was done using 3-(4, 5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against breast cancer cell line (MDA-MB231).
Results: The antioxidant activity of marine red algae was checked using the stable DPPH radical scavenging assay. The antibacterial activity was analyzed and shows the activity of two different bacteria strain against methanol extract. The anticancer activity was done against breast cancer cell line using MTT assay.
Conclusion: Thus, the result shows that red algae G. edulis has good biological activity, and further it can be carried out in pharmaceutical, food preservatives, and cosmetic purpose.
CORRELATIONS OF DEOXYRIBONUCLEIC ACID METHYLATION, HISTONE ACETYLATION, AND MICRORNA‑320 WITH SORBITOL DEHYDROGENASE IN DIABETIC RETINOPATHY
Authors: AMIN RAMZI , HILMANTO DANY , KARTASASMITA ARIEF S. , PERMANA HIKMAT 
Published: October 2019

Objective: Prolonged and persistent hyperglycemia in diabetes mellitus (DM) leads to a variety of vascular complications, including the retinal disorder of diabetic retinopathy (DR). The mechanism of fructose formation of sorbitol assisted by sorbitol dehydrogenase (SDH) causing the loss of pericytes in the blood vessel is affected by epigenetic work comprised of deoxyribonucleic acid (DNA) methylation, histone acetylation, and microRNA‑320. This study aimed to determine the correlation of DNA methylation, histone acetylation, and microRNA‑320 with SDH in DR.
Methods: This case–control study was conducted at a tertiary general hospital from July 2014 to June 2016. Study subjects were type 2 DM patients with and without DR, over 40 years old, suffered from DM for > 10 years. DNA methylation, histone acetylation, and microRNA‑320 were examined by real‑time quantitative polymerase chain reaction, while SDH level examination was carried out by enzyme‑linked immunosorbent assay. Analyses were performed with independent t‑test, Mann–Whitney, Spearman correlation, and multiple linear regression.
Results: With respect to SDH, DNA methylation showed no significant correlation so as histone acetylation, in contrary to microRNA‑320 with a very strong negative correlation (r=−0.968, P < 0.005).
Conclusion: MicroRNA‑320 was correlated to SDH in a manner of protective properties against the occurrence of DR. Involvement of DNA methylation and histone acetylation was perceptible in influencing SDH enzyme despite their insignificance if they took place individually.
Implementation of Backpropagation Neural Network to Detect Suspected Lung Disease
Authors: Syafria Fadhilah , Iqbal Boni , Budianita Elvia , Afrianty Iis 
Published: October 2019

Many People were less concerned with lung health, it caused people identified as suffering from lung diseases. Early symptoms that often appear was cough that took a long time and could be the beginning of more severe disease. Therefore it was necessary to create application that could detect suspected person contracted lung disease. The applications were made by using artificial neural network with Backpropagation with initial input data, symptoms by patients of lung diseases. The symptoms were 22, and kind of lung diseases as a diagnosis were asthma, pneumonia, pulmonary tuberculosis and lung cancer. It used medical records of lung disease as much as 110 data. Network training uses 3 different architectures [input neurons ; hidden neurons ; output neurons], liked [22; 22 ; 2], [22 ; 33 ; 2] and [22 ; 43 ; 2]. Testing with 2 training data sharing and test data, namely comparison 90:10 and 80:20. The Parameters values were used namely learning rate 0.1, 0.3, 0.5, 0.7 and 0.9. The number of epoch was used, that is 15 epoch, 25 epoch and 35 epoch. Based on the tests performed, it was obtained an accuracy system on the 90:10 data comparison of 82% and the 80:20 data ratio of 82% as well. Thus, backpropagation method could be applied in detecting suspected lung diseases.
Nurses’ Knowledge Regarding FoodDrug Interaction in the Intensive Care and Emergency Hospitals
Authors: Lafi Samir Y , Kamali Aram Salih Mohammed Amin , Sharif Bayan Omar 
Published: October 2019

Usually supplement is essential and fundamental components for ensure and creating the human body, also drugs seem to survey the life of each individual and ensure the wellbeing for a long life aimed most of illness, but in case nourishment sedate interaction ignored since of information shortage almost it or any reason maybe lead to futile of medicine for the patients or cause life threatening condition because of that, one of the most significant ethical point in every health care setting in the world is patient's safety; and the care for patients must be improved in every country to prevent complication of interaction between food and drug. The main objective of this cross-sectional study has been conducted to assess the nurses' knowledge regarding food-drug interaction (FDI) at the intensive care in both of Shar and emergency hospitals in the Slemani city, the data were collected during the period of October up to the end of December. Non-probability, (purposive sample) of 78 nurses at both hospitals, a questionnaire was designed according to literatures and books regarding FDI which contained 25 items, 8 items for demographic characteristics, and 17 items concerning FDI. The validity of the questionnaire was given to a panel of 7 experts, a pilot study was carried out to check the reliability of the questionnaire which determined through the use of stability reliability (test-retest) approach which was estimated as r = 0.81. The data were collected through the interviewing of the study sample and analyzed through the using of the Statistical Package for Social Sciences SPSS, version 23, and analyzed through the application of descriptive and inferential statistical analysis. The findings of the present study conclude that more than half of nurses had low knowledge and none of them had high level of knowledge, also there is no significant association between the levels of knowledge with age, gender, educational level, years of experience and working place. The study suggested extends the knowledge of nurses regarding the FDI, by training courses from clinical pharmacologists.
Analysis of the Effect of Various Types of Limestone as a Main Constituent of Cement on the Chosen Properties of Cement Pastes and Mortars
Authors: Gołaszewski J. , Cygan G. , Gołaszewska M. 
Published: October 2019

AbstractThe article is an attempt to compare the impact of the use of various types of limestone as the main constituent of cement on selected mortar properties. Four different limestones were added in amount of 15, 30, 40% to CEM I 42.5 R to obtain limestone cemens. Rheological properties (yield stress, plastic viscosity) of fresh mortar, tensile and compressive mortar strength, early shrinkage, and drying shrinkage were tested. Obtained results indicate that both tensile and compressive strength decreases with the increase of the limestone content in cement. Limestone can worsen or improve workability, depending on distribution of limestone grains. The addition of limestone increases the early shrinkage, but reduces the shrinkage after 28 days. Studies show that the granulation of limestone plays an important role in determining the influence of limestone on mortar properties.
Risk Analysis in the Realization of Buildings in Revitalized Areas
Authors: Sobotka A. , Radziejowska A. 
Published: October 2019

AbstractConstruction work on buildings covered by the revitalization program of historic urban development represents a special type of construction project in which, in the execution phase, difficult technical situations and other risk sources are being encountered. An important source of risk is the necessity to preserve a part of the historic substance, which results, among others, from the recommendations of the conservator, legal regulations or from the vision of the architect/investor. The risk is also associated with difficulties and complications in construction works resulting from the location of these objects in dense urban development. The aim of the article is to identify risk factors and reactions of contractors, i.e. applied risk management methods and techniques, based on the example of a complex of buildings constructed in the historic district of Krakow. The elimination of sources of risk, especially of a technical nature, requires the construction management to be highly skilled and experienced, to carefully prepare the construction work and to design additional solutions to ensure safety at work. The experience gained may serve as a basis for risk analysis and identification during the implementation of projects involving the use of an existing building and historic substance in areas subject to revitalization programs.
Correlation between Compressive Strengths and Water Absorption of Fly Ash Cement Mortar Immersed in Water
Authors: Huang Qian , Zhao Liang 
Published: October 2019

AbstractThe compressive strength and water absorption of cement mortars with different water-binder ratio (0.35, 0.45 and 0.55) and fly ash content (0, 10%, 20% and 30%) under water immersion were investigated, and the correlation between them was further analyzed. The internal microstructure and phase composition of mortar was studied by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. The results show that the inside of mortar mixed with fly ash displayed the loose and porous microstructure. Therefore, the incorporation of fly ash reduced the compressive strength of mortar, especially the early strength, and the strength decreased with the increase of fly ash content, and the water absorption of mortar also increased. There was a linear correlation between the compressive strength and water absorption of mortar with the equation: fc = −3.838β + 62.332, where fc and β represented the compressive strength and water absorption, respectively. Therefore, when the water absorption of mortar immersed in water was measured, its corresponding compressive strength could be preliminarily inferred through this equation, which was of great significance for detecting and identifying the stability and safety of hydraulic structures.
Laryngeal Mask Ventilation during Tracheostomy Improves Intraoperative Hemodynamic Stability in Patients Undergoing Total Laryngectomy
Authors: Marinov Tz. , Popov T. M. , Belitova M. 
Published: October 2019

Abstract

Background and objectives: Laryngectomy with extensive extirpational neck dissection is still the treatment of choice for patients with advanced laryngeal cancer. During the initial part of laryngectomy – tracheostomy, there is a significant upper airway obstruction, caused by the cancer process itself and worsened by surgical pressure and manipulation during creation of tracheostomy. This study aims to make comparative assessment of the patient’s hemodynamic parameters, operated using three of the most popular approaches during tracheostomy: local anesthesia with preserved spontaneous ventilation; general anesthesia with ventilation by endotracheal intubation and general anesthesia with ventilation by laryngeal mask airway.

Methods: A prospective cohort study was conducted in a tertiary referral center. Sixty patients with advanced laryngeal cancer appointed for total laryngectomy, were enrolled in the study. They were randomly assigned into three groups, according to the ventilation method used during the tracheostomy.

Results: Patients who underwent tracheostomy under local anesthesia displayed statistically the highest levels of SAP, DAP, MAP and heart rate intraoperatively. The group of patients who underwent tracheostomy with endotracheal intubation, also displayed significantly higher levels of hemodynamic parameters during the procedure compared with the group with laryngeal mask airway ventilation, despite the fact that both groups were under general anesthesia.

Conclusions: To our knowledge, this is the first study to demonstrate that laryngeal mask ventilation during tracheostomy improves intraoperative hemodynamic stability in patients undergoing total laryngectomy compared to endotracheal intubation.
Markers for Inflammation and Oxidative Stress in Patients with Coronary Artery Disease and Microvascular Disease – Is there a Difference?
Authors: Cherneva Z. , Cherneva R. , Manov E. , Runev N. 
Published: October 2019

Abstract

Introduction: The clinical significance of inflammation (and markers such as resistin, hsCRP) and oxidative stress (e.g. 8-isoprostanes) for microvascular disease (MVD) and coronary artery disease (CAD) is still elusive.

Aims: To determine the role of the markers for inflammation and oxidative stress as independent markers for MVD.

Methods: Ninety consecutive patients were recruited: twenty-five of them had CAD; thirty – MVD and thirty-five were controls. The latter included patients with atypical chest pain, risk factors, lack of coronary artery disease and negative adenosine test. Coronary angiography was performed in all participants. The adenosine test was performed in those without CAD, hs CRP, resistin in plasma and urine 8-isoprostanes were measured. The correlation of all these indicators with CAD and MVD was analyzed.

Results: The 8-isoprostanes showed significant differences between patients with MVD and CAD (0,055/0,52 pg/mmol Cre; p = 0,028). The same trend was found between CAD patients and the control group (0,055/0,003 pg/mmol Cre; p = 0,041); as well as between those with MVD and the control group (0,52/0,003 pg/mmol Cre; p = 0,001). The highest values of 8-isoprostanes were detected in patients with MVD – 0,52 pg/mmol Cre. Markers for inflammation were similar in patients with MVD and CAD (hsCRP- p = 0,091; resistin − p = 0,32).

Conclusions: hs CRP, resistin and 8-isoprostanes are involved in the pathogenesis of both CAD and MVD. However, oxidative stress is probably more important for MVD, therefore 8-isoprostanes can be a part of panel of markers for its detection and analysis.
The Learning of Multivariate Adaptive Regression Splines (MARS) Model in Rainfall-Runoff Processes at Pahang River Catchment
Authors: Halid D.A. , Atan I. , Jaafar J. , Ashaari Y. , Mohamed S.N. , Samsudin M.B. , Baki A. 
Published: October 2019

Abstract
Recently, a novel data mining technique, Multivariate Adaptive Regression Splines (MARS) has begun attracted attention from several hydrological researchers because their application is relatively new in modelling hydrological processes. The power of this approach has been proven in variety learning problems such as financial analysis, species distributions modelling, and doweled pavement performance modelling. Therefore, the objective of this paper is to investigate the performance of MARS model in capture the rainfall-runoff processes at river catchment of Malaysia. Pahang River has been selected as area of study. 30-years data set of daily rainfall and runoff at upstream tributaries of Pahang River were used to developed and validate the capability of MARS model in flood prediction. The effect of different length of record data to performance of MARS model was also examined by arranged the data into 5-years data set, 10 years data set, 20 years data set, and 30 years data set. All these data sets used 1-year data of 2003 for validation process while the others were applied for calibration. Simulation results showed that MARS model was able to learn the rainfall-runoff processes in Pahang River catchment and the model performance improved due to the longer period of data.
Effect of Bio Fertilizers and Inorganic Fertilizers on Growth, Productivity and Quality of Bread Wheat Cultivars
Authors: Hafez E.M. , Badawy S.A. 
Published: October 2019

Abstract
Integrated nutrient management strategies involving chemical and biological fertilizer is a real challenge to stop using the high rates of agrochemicals and to enhance sustainability of crop production. In order to study the effects of biofertilizers (Cerialin and Nitrobein) and chemical nitrogen levels (0, 85,170 and 250 kg N ha−1) on yield and yield attributes of two wheat cultivars (Sakha 94 and Gemmeiza 10), an agricultural experiment in the form of strip-split factorial design with three replications was conducted in Kafr El-Sheikh region, Egypt, in 2014/2015 and 2015/2016 growing seasons. The objective of this study was evaluation of the effects of these fertilizers separately and in integrated forms, and setting out the best fertilizer mixture. The results showed that treatment with biofertilizers and chemical nitrogen increased the growth, yield attributes, biological and grain yield. Both grain and biological yield produced a better result during the combination of nitrogen fertilizer and biofertilizers than using either method alone. Using biofertilizers increased biological yield through increase in number of grains spike−1, number of spikes m−2 and 1000 grain weight, which cause to increase in grain yield with significant changes in harvest index, as well as protein content. We may conclude that using biofertilizers (Cerialin or Nitrobein) and chemical nitrogen fertilizer (170 or 250 kg N ha−1) together had the maximum impact on yield. Then, we can decrease use of chemical fertilizers through using biofertilizers.
Allelopathic Effect of Ficus benjamina Leaf Extract, Litter, and Mulch on Germination and Growth of Sunflower
Authors: Muhammad Z. ,   Rehmanullah, Inayat N. , Majeed A. 
Published: October 2019

Abstract
Allelopathy is an important biological process, which has direct or indirect effects on the germination and growth potentials of plants. Awareness about the allelopathic properties of plants which prevail in agricultural systems can help growers to amend crop cultivation patterns accordingly. In this study, we evaluated the allelopathic effects of Ficus benjamina on germination and early seedling growth of four hybrids of sunflower (Oliver, Parsun-3, SFH-80 and NK-S-278). Ethanolic and hot-water aqueous extracts from leaves, while litter and mulches of the test allelopathic plant significantly reduced germination, radicle and hypocotyle growth of sunflower. Germination percentage was drastically reduced in all the four sunflower hybrids by ethanolic, hot-water and litter extracts; however, compared to control, mulching assay significantly increased germination in hybrids Oliver (76%), Parsun-3 (42%), SFH-80 (78%) and NK-S-278 (30%) at 2, 4, 8 and 12g extract concentration, respectively. Hypocotyle and radicle length of test hybrids were significantly reduced in each assay type. Among tested assays, ethanolic extracts revealed more drastic effects on the studied parameters than hot-water, litter, and mulching. Sunflower hybrid NK-S-278 was more severely affected, while Parsun-3 exhibited resistance to the allelopathic stress. Inhibitory effects were more prominent with increasing concentration of the extracts. The order of the phytotoxic effects of tested bioassays was ethanolic extract˃ hot-water˃ litter˃ mulching. The study suggested that Ficus leaves may possess potent allelochemicals with growth inhibitory effects on sunflower seedlings. It is suggested that further study might be required to check the allelopathic effect of Ficus benjamina on germination and growth of these sunflower hybrids in field conditions.
Dietary Effects of Algerian Sodium Bentonite on Growth Performance and Biochemical Parameters in Broiler Chickens
Authors: Besseboua O. , Ayad A. , Hornick J.L. , Benbarek H. 
Published: October 2019

Abstract
The present experiment was conducted to investigate the effect of supplementing poultry feed with graded levels of Algerian sodium bentonite (Na-B) on growth performance and the development of villus height in jejunum and some biochemical parameters during 50 days in broiler chickens. A number of 420 one-day old broiler chicks (Arbor Acres) were obtained from a commercial hatchery. The birds were randomly allocated into six groups (A, B, C, D, E and F). The treatments were 0 (control), 1%, 2%, 3%, 4% and 5% of Algerian Na-B levels. The results obtained indicate clearly that weight gain in the chickens fed treatments containing 4% Na-B had greater weight gain than the chickens fed different treatments (0, 1%, 2%, 3% and 5% Na-B). Feed conversion rate (FCR) was lower birds supplemented with Na-B 4% (2.45) than control group (3.06). Maximum feed consumption was observed in the birds’ control (5,655.3 g), while the lowest was noted in the chickens with diet added 4% Na-B (5,009.5 g) (p< 0.05). The weight of duodenum, jejunum and ileum was decreased for the Algerian Na-B supplemented group, compared with the control group. The villus height was affected by dietary treatments (1%, 2%, 3% and 5%) on days 18 and 50 (p< 0.05). Feeding the supplemented graded levels Na-B resulted in an increase in plasma cholesterol, triglyceride and HDL concentrations at 50 days of age, compared with the control group. These results showed clearly that the Na-B from Algeria can improve the growth performance in broiler chickens. Thus, dietary inclusion of Na-B had positive effect on plasma triglyceride, cholesterol and HDL values in broiler chickens at the end experiment.