bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Cancer History Accuracy in Primary Care Electronic Health Records Through Cancer Registry Linkage
Authors: Hoopes Megan , Voss Robert , Angier Heather , Marino Miguel , Schmidt Teresa , DeVoe Jennifer E , Soule Jeffrey , Huguet Nathalie 
Published: December 2020

Abstract

Background
Many cancer survivors receive primary care in community health centers (CHCs). Cancer history is an important factor to consider in the provision of primary care, yet little is known about the completeness or accuracy of cancer history data contained in CHC electronic health records (EHRs).

Methods
We probabilistically linked EHR data from more than1.5 million adult CHC patients to state cancer registries in California, Oregon, and Washington and estimated measures of agreement (eg, kappa, sensitivity, specificity). We compared demographic and clinical characteristics of cancer patients as estimated by each data source, evaluating distributional differences with absolute standardized mean differences.

Results
A total 74 707 cancer patients were identified between the 2 sources (EHR only, n = 22 730; registry only, n = 23 616; both, n = 28 361). Nearly one-half of cancer patients identified in registries were missing cancer documentation in the EHR. Overall agreement of cancer ascertainment in the EHR vs cancer registries (gold standard) was moderate (kappa = 0.535). Cancer site–specific agreement ranged from substantial (eg, prostate and female breast; kappa &gt; 0.60) to fair (melanoma and cervix; kappa &lt; 0.40). Comparing population characteristics of cancer patients as ascertained from each data source, groups were similar for sex, age, and federal poverty level, but EHR-recorded cases showed greater medical complexity than those ascertained from cancer registries.

Conclusions
Agreement between EHR and cancer registry data was moderate and varied by cancer site. These findings suggest the need for strategies to improve capture of cancer history information in CHC EHRs to ensure adequate delivery of care and optimal health outcomes for cancer survivors.
The Loango Turn
Authors: Parfitt Tudor 
Published: December 2020

AbstractIn 1777 it was revealed that there were not only white negroes and other weird and wonderful hybrids in Loango, there were also black Jews with some striking customs. This was revealed in a book by Christian George Andreas Oldendorp. The scientists of the Enlightenment were as fascinated by these black Jews as they had been by the white negroes and other hybrids. Some, such as Theophil Ehrmann, were dubious about Oldendorp’s revelation. But leading Enlightenment figures such as Anton Büsching, Conrad Malte-Brun, Johann David Michaelis, Eberhard August Wilhelm von Zimmermann, Kurt Sprengel, and others debated their importance from a racial and historical standpoint. Other black Jews were invoked by Paul Jakob Bruns. The Ethiopian Jews had been introduced to Enlightenment thinkers by James Bruce. Jews, who were anxious to be seen as white, were not much interested in black Jews. An exception was Ludwig Markus, who wrote about Loango Jews and others, including the Falashas of Ethiopia. Black Indian Jews were brought into the conversation and became an important object of Enlightenment speculation about race and color determinism. The idea of a color spectrum for Jews was born.
Determination of Structure
Authors: Leong Daphne 
Published: December 2020

AbstractHow can a performer’s voice complement that of a theorist in the analysis of a musical work? This chapter takes the opening cadenza of Ravel’s Concerto for the Left Hand as a case study. Certain performance considerations—embodied facets, instrumental affordances, and affective implications—comprise warp and weft not only of the Concerto’s execution and interpretation, but also of its structure and meaning. The chapter explores the cadenza: visual and kinesthetic aspects, rhetorical and tonal function, form and structure, rhythmic features and performance issues. The analysis is informed by the authors’ experiences of performing the Concerto and by historical recordings of the work. Video performances and audio examples complement the written text.
Organizational Effects of Intellectual Property (Micro Level)
Authors: Barnett Jonathan M. 
Published: December 2020

AbstractThis chapter identifies real-world circumstances in which secure IP rights are a precondition for innovation specialists to extract value from R&D investments, given the ability of large integrated firms to imitate any successful innovation and capture the market through financing, production, and distribution efficiencies. Survey evidence and other evidence on patent application, issuance, and enforcement indicate that smaller firms tend to place a higher value on patents than larger firms as a mechanism for capturing returns on innovation. A secure IP regime enables firms to select from the full range of monetization structures in order to assemble the maximally efficient mix of organizational forms for executing the innovation and commercialization process.
Narrative and Foundational Assumptions
Authors: Josselson Ruthellen 
Published: December 2020

Abstract
This chapter describes a training program in China involving working intimately with Chinese therapists in quite revealing experiential groups over ten years. The author learned that whatever she could tell about her experiences would be infiltrated by her own Western culture. Her struggle was to bring her embeddedness in a Western perspective into narrative contact with an Eastern, quite different, set of foundational assumptions about life and human relationships. Narrative is always rooted in culture-bound worldviews but can also be a way of bridging them. Culture can only be told in storied form and involves the intersection of self and other. Cross-cultural knowing of the Other is a humbling experience.
Communicable Diseases, Health Security, and Human Rights
Authors: Sekalala Sharifah , Harrington John 
Published: December 2020

Abstract
This chapter examines the influence of human rights in the quest to control communicable diseases. Communicable diseases are emerging and spreading faster than ever before, with devastating consequences for the most vulnerable in a rapidly globalizing world. Human rights have come to frame infectious disease control, beginning in the early response to AIDS and expanding from the stigmatization of marginalized populations to include the provision of essential medicines. Human rights claims have correspondingly expanded, arising out of norms of non-discrimination, consent, and privacy and now including the right to health. As individual rights compete with state authority, the World Health Organization’s (WHO’s) International Health Regulations (2005) aim to guide states in a rights-based response to communicable disease. However, as seen in recent Ebola outbreaks, human rights have lost priority to health security as the dominant frame for health policy, and this securitization of communicable disease control may undermine the gains of human rights, risking the future of global health.
Heteronyms as Virtual Subjects
Authors: Ganeri Jonardon 
Published: December 2020

Abstract
The authorial act of heteronymic self-transformation is quite different from that of inventing a character in a story. What is fundamental to the notion of a heteronym is that it is an othered I, ‘lived by the author within himself’, that is to say, lived first-personally. A heteronym is not a character because the relationship an author stands in to an invented character is a third-personal one. A closer analogy would be with one of those stories in which each section has a different narrator writing from a first-person position, such as Orhan Pamuk’s novel My Name is Red or William Faulkner’s As I Lay Dying. Yet a sequence of distinct narrators writing in the first person is still not a display of heteronymy: they are distinct characters taking it in turn to speak about themselves. When one dreams it is not uncommon for one to oneself figure in the dream, as the one to whom the events in the dream are presenting. The ‘subject-within-the-dream’ is both a virtual subject and a simulation of the dreaming subject; and for this reason it would be entirely appropriate to describe the subject-within-the-dream as the dreaming subject’s heteronym in the dream. The idea of heteronymy is also well-captured in Yasumasa Morimura’s multiple self-portraiture under the assumed identities of famous historical artists.
Intersecting Horizons
Authors: Ganeri Jonardon 
Published: December 2020

Abstract
How are we to imagine a situation in which I am simultaneously yet severally multiple subjects? Many contemporary writers on personal identity have said that one can imagine a scenario involving the fission of a person, a situation where as a result of division what was up to that moment a single person subsequently continues as two distinct people. One solution to the challenge of multiple embodiment is to defend the view that persons are individuals of a special sort, higher-order individuals somewhat akin to kinds. And yet the deeper issue is not metaphysical but phenomenological, and it isn’t a puzzle about the multiple embodiment of a single person but about a person’s simultaneous embrace of multiple first-person positions. Pessoa introduces the term ‘intersection’ as a philosophical term of art to denote the unified phenomenology of a doubled, interwoven experiential state. In one place he gives, as an example, the hypnagogic state. While the hypnagogic state occurs spontaneously, Pessoa claims that states of ‘intersecting sensation’ can also be brought about through the conscious exercise of guided attention. Yet Pessoa abandoned his experiments in intersectionist poetry, and his view seems to have undergone a shift. I wonder if he recognized that the force of the idea behind simultaneous subject plurality, that is, the experiential possibility to be in multiple subject positions simultaneously yet severally, is not fully realized in the concept of an emulsified experience.
Neurocognitive Mechanisms
Authors: Piccinini Gualtiero 
Published: December 2020

Abstract
This book provides the foundations for a neurocomputational explanation of cognition based on contemporary cognitive neuroscience. An ontologically egalitarian account of composition and realization, according to which all levels are equally real, is defended. Multiple realizability and mechanisms are explicated in light of this ontologically egalitarian framework. A goal-contribution account of teleological functions is defended, and so is a mechanistic version of functionalism. This provides the foundation for a mechanistic account of computation, which in turn clarifies the ways in which the computational theory of cognition is a multilevel mechanistic theory supported by contemporary cognitive neuroscience. The book argues that cognition is computational at least in a generic sense. The computational theory of cognition is defended from standard objections yet a priori arguments for the computational theory of cognition are rebutted. The book contends that the typical vehicles of neural computations are representations and that, contrary to the received view, neural representations are observable and manipulable in the laboratory. The book also contends that neural computations are neither digital nor analog; instead, neural computations are sui generis. The book concludes by investigating the relation between computation and consciousness, suggesting that consciousness may have a functional yet not wholly computational nature.
Implementation of health workforce information systems: a review of eight sub-Saharan country experiences
Authors: Chibuzor M , Arikpo I , Aquaisua E , Esu E , Okoroafor S C , Omar S , Effa E , Oyo-Ita A , Meremikwu M 
Published: December 2020

ABSTRACT

Background
Globally, one of the major problems facing health systems is an acute deficit of health workforce. To ensure equitable distribution and deployment of health workers, up-to-date and timely information on the health workforce is vital. Health workforce registries (HWRs) have the potential to generate data for evidence-based human resource planning and policies. There is a lack of evaluative research on the capacity of HWRs to improve health systems. This review aims to assess the effectiveness of HWRs for improving health systems in low- and middle-income countries.

Methods
We searched selected electronic databases from inception to 14 April 2020. Two authors independently screened studies and extracted data from included studies. We presented results as a narrative synthesis.

Results
We included eight studies of moderate–high quality in this review. The results suggest that HWRs can improve the distribution and skill-mix of the health workforce, quality of health workforce data, availability and use of data for policy and planning, and user satisfaction. The evidence was derived from case studies, which limited our ability to infer a causal relationship.

Conclusion
More rigorous research from controlled experimental studies is needed to consolidate the available evidence from observational studies.
On the electrostatic potential for the two-hyperboloid and double-cone of a single sheet with elliptic cross-section
Authors: Vafeas Panayiotis , Sten Johan C -E , Chatjigeorgiou Ioannis K 
Published: December 2020

Summary
The study of the response of divergence-free electric fields near corners and edges, resembling singularities that accumulate charges, is significant in modern engineering technology. A sharp point can mathematically be modelled with respect to the tip of the one sheet of a double cone. Here, we investigate the behaviour of the generated harmonic potential function close to the apex of a single-sheeted two-hyperboloid with elliptic cross-section, whose asymptote is the corresponding elliptic double cone with one sheet present. Hence, the electrostatic potential problem, involving a single sheet of a two-hyperboloid, is developed using the theory of ellipsoidal-hyperboloidal harmonics, wherein the particular consideration enforces as solution in terms of generalised Lamé functions of non-integer order. A numerical method to determine these functions is outlined and tested. We demonstrate our technique to the solution of a classical boundary value problem in electrostatics, referring to a metallic and charged single-sheeted elliptic two-hyperboloid and its double-cone limit. Semi-analytical expressions for the related fields are derived, all cases being accompanied by the necessary numerical implementation.
Resource tracking for neglected tropical disease programmes: the first step for developing a sustainable financing strategy
Authors: Huang Xiao Xian , Toure Hapsatou , Biswas Gautam 
Published: December 2020

Abstract
The adequacy of resources for programme implementation is a premise for achieving the targets set in the road map for neglected tropical diseases (NTDs) 2021–2030. During the decade 2010–2020, international health aid and pharmaceutical donations have driven progress to control and eliminate NTDs. In the next decade, domestic financing will be critical to sustain NTD control and elimination programmes. Tracking domestic resources for NTD programmes through country health accounts, a relatively mature health system resource tracking platform, could be the first step in raising the visibility of NTDs in the discussion of national health resource allocation.
Remdesivir Approved to Treat COVID-19 Amid Controversy
Authors: Aschenbrenner Diane S. 
Published: December 2020

Remdesivir (Veklury) is the first antiviral drug approved to treat patients ages 12 and older who are hospitalized with COVID-19.The drug is administered via slow IV infusion.Elevated liver enzymes are common with treatment. Hypersensitivity reactions, including anaphylaxis, are possible.
Cervical Pessary to Prevent Preterm Birth in Asymptomatic High-Risk Women: A Systematic Review and Meta-analysis
Authors: Conde-Agudelo Agustin , Romero Roberto , Nicolaides Kypros H. 
Published: December 2020

(Abstracted from Am J Obstet Gynecol 2020;223:42–65.e2)
Preterm birth is associated with a multitude of short-term complications in infants compared with term delivery. These short-term complications include respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, sepsis, intraventricular hemorrhage, periventricular leukomalacia, and retinopathy of prematurity.
New perspectives on targeting RAF, MEK and ERK in melanoma
Authors: Dumaz Nicolas , Lebbé Céleste 
Published: December 2020

Purpose of review
Although immune checkpoint inhibitors and small molecule inhibitors targeting the MAPK pathway have revolutionized the management of metastatic melanoma, long-term disease control occurs only for a minority of patients because of multiple resistance mechanisms. One way to tackle resistance is to develop the next-generation of RAF, MEK and ERK inhibitors using our understanding of the molecular mechanisms that fine-tune the MAPK pathway.

Recent findings
Studies on the regulation of the MAPK pathway have revealed a dominant role for homo-dimerization and hetero-dimerization of RAF, MEK and ERK. Allosteric inhibitors that break these dimers are, therefore, undergoing various stages of preclinical and clinical evaluation. Novel MEK inhibitors are less susceptible to differences in MEK's activation state and do not drive the compensatory activation of MEK that could limit efficacy. Innovations in targeting ERK originate from dual inhibitors that block MEK-catalyzed ERK phosphorylation, thereby limiting the extent of ERK reactivation following feedback relief.

Summary
The primary goal in RAF, MEK and ERK inhibitors’ development is to produce molecules with less inhibitor paradox and off-target effects, giving robust and sustained MAPK pathway inhibition.
Cryptotanshinone Attenuates Ischemia/Reperfusion-induced Apoptosis in Myocardium by Upregulating MAPK3
Authors: Wang Hefeng , Pang Wenhui , Xu Xingsheng , You Beian , Zhang Cuijuan , Li Dan 
Published: December 2020

Abstract:
Chinese people have used the root of Salvia miltiorrhiza Bunge (called “Danshen” in Chinese) for centuries as an anticancer agent, anti-inflammatory agent, antioxidant, and cardiovascular disease drug. In addition, Danshen is considered to be a drug that can improve ischemia/reperfusion (I/R)-induced myocardium injury in traditional Chinese medicine. However, Danshen is a mixture that includes various bioactive substances. In this study, we aimed to identify the protective component and mechanism of Danshen on myocardium through network pharmacology and molecular simulation methods. First, cryptotanshinone (CTS) was identified as a potential active compound from Danshen that was associated with apoptosis by a network pharmacology approach. Subsequently, biological experiments validated that CTS inhibited ischemia/reperfusion-induced cardiomyocyte apoptosis in vivo and in vitro. Molecular docking techniques were used to screen key target information. Based on the simulative results, MAPKs were verified as well-connected molecules of CTS. Western blotting assays also demonstrated that CTS could enhance MAPK expression. Furthermore, we demonstrated that inhibition of the MAPK pathway reversed the CTS-mediated effect on cardiomyocyte apoptosis. Altogether, our work screened out CTS from Danshen and demonstrated that it protected cardiomyocytes from apoptosis.
Progression of Parapapillary Choroidal Microvascular Dropout After Disc Hemorrhage in Glaucoma Patients: 2 Case Reports
Authors: Lee Jong Sub , Lee Won June , Lim Han Woong , Seong Mincheol 
Published: December 2020

Purpose:
Microvasculature dropout (MvD) is a novel finding seen in optical coherence tomography angiography (OCTA), which is characterized by a localized dehiscence of the choriocapillaris in the parapapillary atrophy area. Disc hemorrhage (DH) is an important factor often associated with the development and especially progression of glaucoma. Here, we present 2 cases of MvD progression with DH.

Methods and Results:
Case 1: A 62-year-old female patient with normal tension glaucoma in both her eyes had recurrent DH at the inferior area of her right eye. A new DH was observed in the inferotemporal area of the right eye with MvD progression on OCTA in the same direction three months from the baseline.
Case 2: A 57-year-old female patient with bilateral steroid-induced secondary glaucoma also had recurrent DH in her right eye. Four months from the baseline, DH occurred in the superotemporal and inferotemporal area of the right eye, and MvD was detected on OCTA in the superotemporal corresponding direction. After 19 months from the baseline, OCTA was repeated. The DH had resolved, but the superotemporal MvD persisted.

Conclusions:
The 2 cases presented here are the first to report on the relationship between MvD progression and DH. MvD as visualized in OCTA imaging looks to be of clinical importance, and hopefully future studies will reveal the actual connection between MvD, DH, and glaucoma progression.
Clinical Use of PanoMap for Glaucoma: Frequently Damaged Areas in Early Glaucoma
Authors: Lee Won June , Shin Yong Un , Lim Han Woong , Cho Heeyoon , Park Ki Ho , Seong Mincheol 
Published: December 2020

Précis:
Recognizing the shortcomings of poor consistency of the fovea-disc relationship at different time points and comparing PanoMaps may well facilitate the understanding of the spatial relationship between parapapillary and macular areas in glaucoma.

Purpose:
The aims of this study are to analyze the spatial distribution of the frequently damaged areas in early glaucoma, compare the patterns between nonprogressors and progressors using the combined wide-field parapapillary and macular deviation maps (PanoMap), and to evaluate the consistency of the fovea-disc relationship in PanoMap. The fovea-disc distance (FDD) and fovea-disc axis (FDA) were compared at baseline and at the last follow-up.

Materials and Methods:
In total, 118 patients with early glaucoma and a minimum follow-up period of 3 years were included in this retrospective observational study. The pattern of structural changes was evaluated by averaging the PanoMaps of the enrolled patients at baseline and last follow-up. Longitudinal comparison of the FDD and FDA was performed at baseline and the last follow-up. Patients were divided into nonprogressor (n=44) and progressor (n=74), and the patterns of glaucoma progression in PanoMaps were compared between them.

Results:
At baseline, the glaucomatous damage was found more frequently in the macular compared with the parapapillary area. The spatial distribution of frequently damaged areas was similar between the nonprogressor and progressor. At the last follow-up, compared with the baseline structural change on the PanoMap, the progressive structural changes extended toward the fovea at both the parapapillary and macular areas in the progressor. The FDD and FDA were significantly different between the baseline and the last follow-up.

Conclusions:
The PanoMaps showed a clear spatial distribution of early glaucomatous changes, indicating that the damaged area was frequently observed in the macular area. As the consistency of the fovea-disc relationship in PanoMaps was not excellent, this aspect should be considered when interpreting the PanoMap.