bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does land use type impact the demographic and spatial structures of Adansonia digitata L. in the Pendjari Biosphere Reserve in Northern Benin?
Authors: ASSOGBA Orgely Doris Imeilda , SALAKO Kolawolé Valère , FANTODJI Benjamin , ASSÉDÉ Éméline P. S. , ASSOGBADJO Achille Ephrem , CHIRWA Paxie Wanangwa 
Published: October 2020

Changes in land use type (LUT) are a major driver of biodiversity loss and species decline. Responses to changes in LUT are species-specific, which may in turn be context-dependent. Understanding such responses is essential for the management of socio-economically important wild tree species. The baobab, Adansonia digitata L., is an important traditional agroforestry tree species in Sub-Saharan Africa. This study assesses how LUT affects the demographic and spatial structure of baobab stands. Using data from a census and mapping of baobab trees in 12 plots of 250 m × 250 m each, the study compared baobab tree density, total height and diameter, diameter size-class distribution (SCD), stand stability, and spatial relationships in a strictly protected area (national park), a buffer zone and farmlands (Matéri and Boukombé) in the Pendjari Biosphere Reserve in Benin. The results show that the highest young and adult tree densities are in farmlands (particularly in Matéri), followed by the buffer zone and the national park. No significant differences in tree diameter and total height of baobab trees were found among the different LUT. The SCD had a reverse J-shape with a better negative slope and population stability metrics in farmlands (particularly in Matéri) but a flattened slope in the buffer zone. The spatial distributions of juvenile and adult baobab trees were random, and independent of each other. The spatial distribution of juvenile and adult baobabs was also independent of the other tree species, irrespective of LUT. It was concluded that baobab conservation is better in farmlands than in the national park but that the difference between park and farmlands may be context-dependent, probably linked to local environmental conditions, the socio-ecological context and interactions with baobab trees.
ARTICULO RETRACTADO; Impacto de la suplementación con micronutrientes sobre la desnutrición crónica infantil en Perú
Authors: Francke Pedro , Acosta Gustavo 
Published: October 2020

Artículo Retactado

DOI: https://doi.org/10.20453/rmh.v33i1.4173

El Consejo de editores de la Revista Médica Herediana comunica la retractación del artículo titulado
Impacto de la suplementación con micronutrientes sobre la desnutrición crónica infantil en Perú
(1) de los autores Pedro Francke y Gustavo Acosta, publicado en el volumen 31 número 3 julio-setiembre, año 2020, luego de comprobarse que se trata de una publicación duplicada o redundante, no autorizada.

El estudio completo fue publicado previamente en el artículo titulado “Evaluación del Impacto de “Chispitas”,
Suplemento Ferroso (Terapéutico) y Qali Warma sobre la Anemia y la Desnutrición Crónica Infantil”
(2) , en la revista Economía, Sociedad y Estadística en enero de 2020.

https://revistas.upch.edu.pe/index.php/RMH/article/view/4173/4721
Hyperglycemia, Inflammatory Response and Infarct Size in Obstructive Acute Myocardial Infarction and MINOCA
Authors: Paolisso Pasquale , Foà Alberto , Bergamaschi Luca , Donati Francesco , Fabrizio Michele , Chiti Chiara , Angeli Francesco , Toniolo Sebastiano , Stefanizzi Andrea , Armillotta Matteo , Rucci Paola , Iannopollo Gianmarco , Casella Gianni , Marrozzini Cinzia , Galiè Nazzareno , Pizzi Carmine 
Published: October 2020

Hyperglycemia has been associated with increased inflammatory indexes and larger infarct sizes in patients with obstructive acute myocardial infarction (obs-AMI). In contrast, no studies have explored these correlations in non-obstructive acute myocardial infarction (MINOCA). We investigated the relationship between hyperglycemia, inflammation and infarct size in a cohort of AMI patients that included MINOCA.
Patients with AMI undergoing coronary angiography between 2016 and 2020 were enrolled. The following inflammatory markers were evaluated: C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-platelet ratio (NPR). Myocardial infarct size was measured by peak high sensitivity troponin I (Hs-TnI) levels, left-ventricular-end-diastolic-volume (LVEDV) and left ventricular ejection fraction (LVEF).
The final study population consisted of 2450 patients with obs-AMI and 239 with MINOCA. Hyperglycemia was more prevalent among obs-AMI cases. In all hyperglycemic patients - obs-AMI and MINOCA - NLR, NPR, and LPR were markedly altered. Hyperglycemic obs-AMI subjects exhibited a higher Hs-TnI, a larger LVEDV and a lower LVEF compared to normoglycemic ones. Conversely, MINOCA patients showed similar myocardial damage, irrespective of glycemia.
Our data confirm the association of hyperglycemic obs-AMI with elevated inflammatory markers and larger infarct sizes. MINOCA patients exhibited modest myocardial damage, regardless of admission glucose levels.
PERAN SENTRA BATIK KAUMAN DAN PESINDON UNTUK MENCAPAI KOTA PEKALONGAN SEBAGAI KOTA KREATIF KERAJINAN
Authors: Andriani Rifdahastuti , Astuti Winny , Putri Rufia Andisetyana 
Published: October 2020

<em>Kota Pekalongan merupakan kota kreatif pertama kategori kerajinan dan kesenian rakyat di Indonesia versi UNESCO yang ditetapkan pada tahun 2014. Hal ini tidak terlepas dari adanya sentra-sentra batik yang menjadi ikon dalam perkembangan industri batik di Kota Pekalongan termasuk di Sentra Batik Kauman dan Pesindon. Kedua sentra industri batik ini menjadi salah satu alternatif promosi batik dan rekreasi di Kota Pekalongan. Pelibatan aspek komunitas kreatif dan lingkungan kreatif berupa penyelenggaraan event mempengaruhi pemasukan dan kegiatan di Sentra Batik Kauman dan Pesindon sehingga mengalami perubahan. Artikel ini bertujuan untuk menganalisis perubahan di Sentra Batik Kauman dan Pesindon sejak penetapan Kota Pekalongan sebagai kota kreatif kerajinan. Ada beberapa aspek yang dilihat perubahannya yaitu: (1) pemeliharaan ekonomi kreatif, (2) komunitas kreatif, (3) lingkungan kreatif dan (4) penyelenggaraan event. Artikel ini menggunakan metode penelitian deskriptif kuantitatif dengan teknik analisis statistik deskriptif. Teknik analisis statistik deskriptif digunakan untuk menganalisis perubahan pada empat aspek tersebut. Survei yang dilakukan untuk penelitian ini adalah survei primer yang terdiri dari kuesioner, wawancara dan observasi serta survei sekunder dalam bentuk data. Hasilnya adalah pada aspek pemeliharaan ekonomi kreatif mengalami perubahan yaitu dari sisi SDM yang berinovasi, penyerapan tenaga kerja, jumlah perusahaan dan teknologi. Pada aspek komunitas kreatif yang mengalami perubahan yaitu dari sisi organisasi masyarakat. Untuk aspek lingkungan kreatif, yang mengalami perubahan yaitu dari sisi sarana untuk pusat pelatihan dan toko kerajinan. Sedangkan pada aspek lingkungan kreatif di Sentra Batik Pesindon yang mengalami perubahan hanya pada sarana untuk pusat pelatihan. Selanjutnya pada aspek penyelenggaraan event yaitu dari sisi program penyelenggaraan event untuk promosi mengalami perubahan.</em>
Piriformis Pyomyositis Presenting as Migratory Hip to Knee Pain
Authors: Ou Yang Youheng , Lo Daryl Yin Keong , Ke Yuhe , Lee Dave Yee Han 
Published: October 2020

Case:
The authors report a case of piriformis pyomyositis in a teenage female patient with fever and left hip pain. Her pain migrated to the knee with concurrent near resolution of hip pain. Imaging revealed an abscess in the left piriformis with pus tracking along the sciatic nerve sheath. This was complicated by internal iliac vein thrombosis and an embolus to the lung. Open drainage was performed, followed by outpatient intravenous cloxacillin and oral warfarin, with complete resolution of symptoms.

Conclusion:
Piriformis pyomyositis is a rare condition with varying presentations. The threshold for suspicion should be low even in healthy young individuals.
Mobile Applications for COVID-19: A Scoping Review of the Initial Response in Canada
Authors: Noronha Noella , D'Elia Alessia , Coletta Giulia , Wagner Nicole , Archer Norman , Navarro Tamara , Lokker Cynthia 
Published: October 2020

Abstract
Background: The rapid outbreak of Coronavirus diseases (COVID-19) originating in Wuhan, China, and the subsequent declaration of a state of “pandemic” on March 11, 2020 has necessitated a widespread global response to manage and control the transmission, spread and impact of COVID-19. Mobile technology has been leveraged in a number of ways to control the spread of COVID-19, including to support knowledge translation. Mobile applications are accessible, acceptable, easily adopted, and have the ability to support social distancing efforts. The following review assesses the mobile applications currently available to address COVID-19 and seeks existing studies in the literature that evaluate such applications. Methods: 3 databases (Embase, Web of Science and PubMed), 2 application stores (GooglePlay and Apple’s App Store) and google search engine were searched from inception until April 05, 2020 using key words and search strings to identify relevant apps and/or literature. Reviews of the obtained results were examined by two reviewers in double-blind nature and assessed for inclusion or exclusion. Results: 36 studies, 72 websites and 312 mobile-based applications were identified through searches. 14 applications met the inclusion criteria and were analyzed. Additional eHealth tools identified through the search strategy were considered for supplemental analysis (including online dashboards and applications not available through application stores).Conclusion: This review provides a brief assessment of the goals of applications addressing COVID-19, the types of approaches being used by these applications, and draws conclusions on the needs not being met by such application-based interventions. Innovation and collaboration between government, healthcare organizations and application developers is needed to address the identified gaps and facilitate the successful harnessing of mobile applications in the management of COVID-19.
The C-terminal fragment of LRRK2 with the G2019S substitution increases the neurotoxicity of mutant A53T α-synuclein in dopaminergic neurons in vivo
Authors: Cresto Noémie , Gardier Camille , Gaillard Marie-Claude , Gubinelli Francesco , Roost Pauline , Molina Daniela , Joséphine Charlène , Dufour Noëlle , Aurégan Gwenaelle , Guillermier Martine , Bernier Sueva , Jan Caroline , Gipchtein Pauline , Hantraye Philippe , Chartier-Harlin Marie-Christine , Bonvento Gilles , Camp Nadja Van , Taymans Jean-Marc , Cambon Karine , Liot Géraldine , Bemelmans Alexis-Pierre , BROUILLET Emmanuel 
Published: October 2020

Abstract
Background: Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) likely play crucial roles both in sporadic and familial forms of Parkinson’s disease (PD). The most prevalent mutation in LRRK2 is the G2019S substitution, which induces neurotoxicity through increased kinase activity. There is likely an interplay between LRRK2 and α-syn involved in the neurodegeneration of dopaminergic (DA) neurons in the substantia nigra (SNpc) in PD. However, the mechanisms underlying this interplay are ill-defined. Here, we investigated whether LRRK2 G2019S can increase the neurotoxicity induced by a mutant form of α-syn (A53T mutation) in DA neurons in vivo . Methods: We used a co-transduction approach with adeno-associated virus (AAV), AAV2/6 vectors encoding human α-syn A53T and the C-terminal portion of LRRK2 (ΔLRRK2), which contains the kinase domain, with either the G2019S mutation (ΔLRRK2 G2019S ) alone or the D1994A mutation (ΔLRRK2 G2019S/D1994A ), which inactivates the kinase activity of LRRK2. The AAVs were co-injected into the rat SNpc and histological evaluation was performed at 6- and 15-weeks post-injection (PI). Results: The majority of SNpc neurons co-expressed ΔLRRK2 and human α-syn A53T after transduction. ΔLRRK2 G2019S alone produced no cell loss at 15-weeks PI. Injection of AAV-α-syn A53T alone or mixed with a control AAV coding for GFP produced a significant loss of DA neurons. Co-injection of AAV-α-syn A53T with AAV-ΔLRRK2 G2019S instead of GFP slightly exacerbated that neuronal loss We also studied the inactive form, ΔLRRK2 G2019S/D1994A at 6 weeks PI. Injection of AAV-ΔLRRK2 G2019S mixed with AAV-α-syn A53T produced a neurotoxic effect that was stronger than that produced by the co-injection of AAV-DLRRK2 G2019S/D1994A and AAV-α-syn A53T . Conclusion: Thus, these results show that mutant LRRK2 may selectively facilitate α-syn toxicity in DA neurons through a cell-autonomous mechanism involving its kinase domain. However, considering that the effect of ΔLRRK2 G2019S upon human α-syn A53T is moderate in our paradigm where pathological proteins are overexpressed, the study supports the hypothesis that the interplay between LRRK2 and α-syn may also implicate non-cell-autonomous mechanisms such as those involved in neuroinflammation and spreading of α-syn aggregated species.
Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer: A multi-center study from China
Authors: Chang Xiao , Deng Wei , Wang Xin , Zhou Zongmei , Yang Jun , Guo Wenling , Liu Miaoling , Qi Xiaolu , Li Ling , Zhang Kaixian , Zhang Min , Shi Yonggang , Liu Ke , Zhao Yidian , Wang Huitao , Yu Zhilong , Zhang Jihong , Wang Lihua , Qiao Xueying , Han Chun , Zhu Shuchai , Zhang Ruohui , Chen Junqiang , Hu Cairong , Zhang Fuquan , Hou Xiaorong , Pang Qingsong , Zhang Wencheng , Li Gaofeng , Lin Hailei , Sun Xinchen , Ge Xiaolin , Li Caihong , Ge Hong , Li Dingjie , Wang Yadi , Lu Na , Gao Xianshu , Qin Shangbin , Tian Yuan , Xiao Zefen 
Published: October 2020

Abstract
Purpose: To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies. Methods: Sixteen cancer centers throughout China participated in this study. In Phase 1, three suitable cases with upper, middle, and lower TEC were chosen, and participants were asked to contour a group of gross tumor volume (GTV-T), nodal gross tumor volume (GTV-N) and clinical target volume (CTV) for each case based on their routine experience. In Phase 2, the same clinicians were instructed to follow a contouring protocol to re-contour another group of target volume. The variation of the target volume was analyzed and quantified using dice similarity coefficient (DSC). Results: Sixteen clinicians provided routine volumes, whereas ten provided both routine and protocol volumes for each case. The IOV of routine GTV-N was the most striking in all cases, with the smallest DSC of 0.37 (95% CI: 0.32-0.42), followed by CTV, whereas GTV-T showed high consistency. After following the protocol, the smallest DSC of GTV-N was improved to 0.64 (95% CI: 0.45-0.83, P=0.005) but the DSC of GTV-T and CTV remained constant in most cases. Conclusion: Variability in target volume delineation was observed, but it could be significantly reduced and controlled using mandatory interventions.
WITHDRAWN: The lncRNA XIST promotes colorectal cancer cell growth through regulating the miR-497-5p/FOXK1 axis
Authors: Wang Nan , He Jia-Xing , Jia Guo-Zhan , Wang Ke , Zhou Shuai , Wu Tao , He Xian-Li 
Published: October 2020

Abstract

Background: Recent studies suggest that long noncoding RNAs (lncRNAs) play an important role in tumorigenesis. As a newly identified lncRNA, the role of XIST in colorectal cancer (CRC) has not been established. Here, we sought to characterize the role of XIST and its associated regulatory network in CRC cells.Methods: Expression of XIST mRNA, miR-497-5p, and forkhead box k1 (FOXK1) in CRC cells and tissues were detected using quantitative real-time polymerase chain reaction (qRT-PCR). Proliferation and apoptosis of CRC cells were determined using the CCK-8 cell counting assay and flow cytometry. The rate of cell migration and invasion was determined using a transwell assay. The relationships between XIST, miR-497-5p, and FOXK1 were predicted based on these results, and confirmed using a dual-luciferase reporter assay. Expression of FOXK1 protein was quantified by Western blot.Results: XIST and FOXK1 expression were significantly upregulated in CRC tissues and cell lines, while miR-497-5p expression was downregulated. XIST knockdown significantly suppressed CRC cell proliferation, migration, and invasion. Silencing of XIST also reversed the downregulation of miR-497-5p and upregulation of FOXK1. Moreover, blocking XIST expression was shown to inhibit CRC tumor growth in vivo and the effects were antagonized by the loss of miR-497-5p. miR-497-5p was shown to act as a sponge of XIST and also targeted FOXK1 in CRC cells.Conclusion: XIST was shown to promote the malignancy of CRC cells by competitively binding to miR-497-5p, resulting in an increase in FOXK1 expression. These results suggest that targeting of XIST may represent a possible treatment for colon cancer.
Pediatric burn outcome; Diagnostic Value of R-Baux and P-Baux Scores
Authors: Nia Kavous Shahsavari , Razzaghi Alireza , Rahmani Farzad , Soleimanpour Hassan , Khalili Ayda , Saadati Mohammad 
Published: October 2020

Abstract
The authors have requested that this preprint be removed from Research Square.
Strategies for increasing gait speed in patients with hip osteoarthritis: their clinical significance and effects on hip loading
Authors: Tateuchi Hiroshige , Akiyama Haruhiko , Goto Koji , So Kazutaka , Kuroda Yutaka , Ichihashi Noriaki 
Published: October 2020

Abstract
Background: Changes in gait speed are required in various situations and can be achieved by changing stride length, cadence, or both. Differences in strategies for increasing gait speed may have different effects on hip joint and physical function. The purpose of this study was to determine the effects of strategies for increasing gait speed on hip pain, physical function, and changes in hip loading during gait in patients with hip osteoarthritis (OA). We hypothesized that patients who increase gait speed mainly by increasing cadence would have lesser hip pain, a higher physical function, and a lower rate of increase in hip moments with increasing gait speed.Methods: Forty-seven patients with secondary hip OA (age, 48.3 ± 11.0 years) were included. Gait speed, stride length, cadence, and peak and impulse of the hip moments were measured during gait at self-selected normal and fast gait speeds. The patients were classified as types S (with mainly increasing stride length, n = 11 [23.4%]), C (with mainly increasing cadence, n = 23 [48.9%]), and SC (with increasing stride length and cadence, n = 13 [27.7%]) according to whether they used changes in stride length and/or cadence to transition from normal to fast gait. Hip pain, physical function, and hip moments changes during gait were compared between types.Results: The physical function was higher in types C (38.0 ± 8.8, P = 0.018) and SC (40.6 ± 8.5, P = 0.015) than in type S (28.2 ± 7.8), even after adjustment for age and minimum joint space width. Hip pain was not significantly different between types. The robustness of these results was confirmed with sensitivity analysis. The rates of increases in peak external hip adduction (P = 0.003) and internal rotation moments (P = 0.009) were lower in type C than in type SC.Conclusions: Type C tended to suppress the increase in hip moments during fast gait. Types C and SC, which included increased cadence, maintained higher physical function levels than type S. Encouraging the use of cadence-increasing strategy may be useful for reducing hip loading and maintaining physical function in patients with hip OA.
UVB-Induced Nuclear Translocation of PTEN Promotes Radiation Sensitivity of Human Malignant Glioma U87MG Cells
Authors: Zhao Wei , Yao Chao , An Yang , Jia Yuting , Song Zhenhua , Sun Leilei , Ji Shaoping , Ma Li , Wang Fengling 
Published: October 2020

Abstract
BackgroundPTEN is a tumor suppressor gene, which is often inactivated through mutation and/or deletion in diverse human tumors. In the cytoplasm, PTEN negatively regulates the phosphatidylinositol 3′ kinase (PI3K) signaling pathway, while PTEN also shuttles to the nucleus, where PTEN stabilizes genome and/or participates in DNA repairment after damage. PTEN’s subcellular localization seems to be regulated by various factors. MethodsU87MG cells with expressing Wild-type-PTEN (WT-PTEN) and K13E-PTEN mutant were engineered respectively. The relationship between UV radiation and PTEN’s subcellular localization were elucidated using nuclear and cytosolic fractionation and fluorescence co-localization assay. Related signaling pathways were studied with western blot assays.ResultsHere, we demonstrated that UV irradiation could promote nuclear translocation of both WT-PTEN and K13E-PTEN mutant in a dose-dependent manner, but WT PTEN had a higher level of nuclear accumulation after inducing by UV-irradiation compared to K13E-PTEN. In contrast, the cytoplasmic-nuclear translocation of exogenous PTEN was critical to its tumor-suppressing functions that made U87MG cells more sensitive to the UV irradiation. ConclusionOur findings may have implications for further revealing the function of nuclear PTEN and provide insights for clinical treatment of PTEN-deficient tumors.
Phase Transition of Metal–Organic Frameworks for Constructing Nanocomposite Materials
Authors: Ren Zhen , Zhou Weiqiang , Weng Jie-Na , Qin Ziyue , Liu Liwei , Ji Ning , Khalil Islam , Zheng Bing , Wu Jiansheng , Zhang Weina , Huo Fengwei 
Published: October 2020

Abstract
Through encapsulating functional materials, metal–organic framework (MOF) composites show extraordinary potential in various fields due to the excellent synergistic effects between the host and guests. However, many attracting functional species, such as enzymes, could be easily damaged during the synthesis of MOF composites. Herein we report a new strategy, namely pressure-amorphization-stimulation-recovery (PASR), in which crystalline MOFs were transferred to the amorphous MOFs at certain mechanical pressure, followed by recrystallization process to encapsulate functional species into MOF crystals. The reversible phase transition avoids high temperature, high ionic strength, strong acid/base conditions, etc., which is suitable for many types of functional species. To prove the feasibility of this method, enzymes, anti-cancer drugs, noble metal nanoparticles and other functional materials, have been trapped into MOFs using this strategy. The synthesized MOF composites can maintain 95.6% of the enzyme activity under the treatment of protease, or reach 40% drug loading, or achieve 98% size selectivity for olefins. This strategy has been extended to several types of MOF structures and it will pave a new way for designing MOF composites and developing further applications.