bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Value of Urethral Sphincter Complex Volume for Persistent High Voiding Pressure in Female Urethral Diverticulum Patients Post-Diverticulectomy
Authors: Chen Jen-Chieh , Pan Po-Hsun , Lin Chih-Chieh , Lin Alex T. L. , Huang Eric Yi-Hsiu , Fan Yu-Hua 
Published: December 2024

Abstract

Purpose
This study evaluated the relationship between urethral diverticulum volume (UDv), urethral sphincter complex volume (USCv), clinical and urodynamic characteristics, and surgical outcomes in women with UD.
Methods
A retrospective study was conducted on 53 female patients who underwent diverticulectomy for UD. They were divided into two groups: proximal/middle UD (pmUD, n = 43) and distal UD (dUD, n = 10). Preoperative assessments included videourodynamic study (VUDS) and magnetic resonance imaging, with a follow-up VUDS 1 month post-surgery.
Results
Compared to the dUD group, pmUD patients were less likely to present with a vaginal lump (37.2% vs. 80.0%, p = 0.031) but had significantly larger USCv (9.96 ± 5.91 cm3 vs. 5.23 ± 1.19 cm3, p < 0.001) and UDv (6.27 ± 7.40 cm3 vs. 0.84 ± 0.81 cm3, p < 0.001). The pmUD patients had longer surgeries and higher recurrence rates (32.6% vs. 0%, p = 0.018). In the pmUD group, 24 patients had bladder outlet obstruction (BOO) and 25 exhibited high-pressure voiding (> 20cmH2O). No significant association was found between UDv or USCv and recurrence, unresolved BOO, or high-pressure voiding status. However, a USCv cutoff of ≥ 8.2 cm3 was identified, predicting unresolved high-pressure voiding status post-surgery (p = 0.023). Additionally, 9.3% pmUD patients developed de novo stress urinary incontinence, correlated with larger UDv (11.5 ± 14.3 cm3 vs. 5.9 ± 6.4 cm3, p = 0.02).
Conclusion
A USCv cutoff of ≥ 8.2 cm3 was identified as a predictor for unresolved high-pressure voiding after diverticulectomy.
A cluster-randomized controlled trial of a family-based psychosocial intervention to prevent childhood obesity from preschool ages: the PRESAFALIN study protocol.
Authors: Berruezo Paula , Homs Clara , Estrada Lidia , Lopez-Iglesias Gisela , Lecegui Paula , Valdés-Querol Gina , Carmona-Bach Maria , Mas-Ribera Berta , Orive-Vidal Anna , Araoz Agustina , Según Genís , Torres Silvia , Kim Tina , Díez Julia , Cereijo Luis , Schröder Helmut , Franco Manuel , Gómez Santiago Felipe 
Published: December 2024

Abstract

Background: Childhood obesity is a major global concern, and Spain's high obesity rates highlight the urgent need for effective and innovative interventions in early age. The PRESAFALIN study aims to promote parental competence, self-efficacy, and resilience to improve children's healthy behaviors and reduce the risk of developing obesity.
Methods: This cluster randomized trial will involve 120 child day care centers and public nursery schools across Catalonia and Madrid, Spain, engaging 1,200 families with children aged 0 to 5 years. The study will evaluate children’s zBMI and health-related variables among children, parents/caregivers, and educators through both in-person and self-reported measures. The intervention will unfold in three phases: a 10-month cycle of family group and individual workshops, along with pedagogical and communication materials in the short term. Follow-up and ongoing support will continue up to age 12 in the mid- and long-term phases.
Discussion: The study's strengths include a holistic, flexible approach, long-term follow-up, emphasis on educator training, and socioeconomic equity. Moreover, it will address challenges like self-selection bias and attrition. Overall, the PRESAFALIN study aims to provide valuable insights into how early interventions on parental psychosocial factors determine childhood obesity, guiding scalable public health strategies.
Trial Registration: This study protocol is registered and approved in the ISRCTN registry (ISRCTN 15553317).
Bayesian mixed effect models to account for environmental modulators of acute malnutrition treatment in children
Authors: Sánchez-Martínez Luis Javier , Faes Christel , Charle-Cuéllar Pilar , Samake Salimata , Samake Mahamadou N’tji , Bagayoko Aliou , Bunkembo Magloire , Gado Abdoul Aziz , Sanoussi Atté , Ousmane Nassirou , Lazoumar Ramatoulaye Hamidou , Hernández Candela Lucía , López-Ejeda Noemí 
Published: December 2024

Abstract

Acute child malnutrition is a global public health problem influenced by very diverse factors, including socioeconomic and dietary aspects, but also seasonal and geographic factors. The present study is a secondary analysis that attempts to characterize which variables have influenced the Middle Upper-Arm Circumference (MUAC) upon admission and the Length of Stay (LOS) for treatment recovery. The sample of children analysed was 852. Initially, data cleaning and a reduction of the dimensionality of dietary diversity were carried out. A selection of the importance of the variables using the Watanabe Akaike Information Criteria (WAIC) was carried out prior to the adjustment of Bayesian mixed effects models, with the variables of travel time to health site and week of admission as random factors, on the MUAC and LOS variables. Clear differences were seen between both contexts. Highlighting significant interactions of travel time in Niger while the seasonal effect stood out in Mali. The MUAC models identified a positive effect of age in both contexts, and in Niger, influences of diet diversity, comorbidities, breastfeeding and vaccination appeared. On the other hand, the LOS models highlighted the severity upon admission, and in Niger also factors related to the treatment protocol and the distance to the water source, while in Mali, the quality of water was more decisive. The present study shows the importance of considering acute child malnutrition from a multidimensional and complex approach, where diverse factors (biological, socioeconomic, ecological, etc.) can influence directly or as modulators of the disease and its treatment.
The association between proton pump inhibitor use and risk of osteoarthritis: a cross-sectional study
Authors: Zhang Lisheng , Xiong Ling , Sun Yuanting , Feng Fabo , Lin Yanze 
Published: December 2024

Abstract

Background
Proton pump inhibitors (PPIs) are widely used for managing gastrointestinal conditions, but emerging evidence suggests a potential association with osteoarthritis (OA). This study aims to evaluate the relationship between PPI use and OA, and to investigate whether prolonged PPI use further contributes to OA risk.
Methods
We performed a cross-sectional analysis using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018. PPIs use information was obtained by using prescription medications in the preceding month, and OA status was identified via standard questionnaire. Multivariable regression models were employed to estimate the association between PPIs use and OA after the adjustment for potential confounders. Subgroup analyses were conducted to explore potential interaction effects based on age, gender, race, and body mass index.
Results
A total of 18,605 participants were included in the analysis, of whom 2,090 had OA. After adjusting for all covariates, multifactorial logistic regression revealed a significant association between PPI use and increased OA risk (OR = 1.855 95%CI = 1.549–2.221, P < 0.001). Notably, a dose-response relationship was identified, with each additional year of PPI use increasing OA risk by 7.6% (OR: 1.076, 95% CI: 1.049–1.103, P < 0.001). Subgroup analyses showed that PPI use was significantly associated with OA risk across all populations, with the exception of young adults, other Hispanic, and other racial groups. Of particular note, in middle-aged and Mexican American subpopulations, prolonged PPI use corresponded with a significant higher OA risk.
Conclusions
This study demonstrates a significant association between PPI use and an increased risk of OA, with a further risk increment observed with prolonged PPI.
Predicting acute rejection in simultaneous pancreas-kidney transplantation using donor- derived cell-free DNA as biomarker
Authors: Liu Luhao , Li Guanghui , Zhang Peng , Chen Rongxin , Ouzaouit Abdelhak , Jiang Tingya , Guo Yuhe , Fang Jiali , Ma Junjie , Chen Zheng 
Published: December 2024

Abstract

Background:
Donor-derived cell-free DNA (dd-cfDNA) has been evaluated as a rejection marker in organ transplantation. Here, we assessed the predictive and diagnostic utility of dd-cfDNA for the detection of acute rejection (AR) in patients who have undergone simultaneous pancreas-kidney transplantation (SPKT).
Material and Methods:
Between June 2019 and January 2022, 60 patients with end-stage renal disease were registered to undergo simultaneous pancreas and kidney transplantation at the Organ transplantation department of the Second Affiliated Hospital of Guangzhou Medical University. Patients diagnosed with biopsy-proven AR (n = 30), and normal graft function (n = 30) were divided into AR group and stable group, respectively.
Results:
The time for diagnosing and confirming a rejection incidence in the AR group was (17 ± 4) days post-operation where plasma dd-cfDNA was found to be 5.4 ± 2.0%. In the stable group however, the plasma dd-cfDNA was 1.70 ± 0.48% at 2 weeks post-operation, showing a statistically significant difference (P < 0.01). The SNP-based dd-cfDNA assay discriminated patients with active rejection from non-rejection when dd-cfDNA cut-off was 1.81%, showing an area under the curve, sensitivity and specificity of 0.86, 95.7% and 57.1% respectively.
Conclusion:
The significant increase in plasma dd-cfDNA in SPKT recipients with acute rejection signify that its use as biomarker could facilitate timely detection of graft rejection for the initiation of prompt management strategies among recipients.
Evaluation of the Analgesic Effect of Laser Therapy at Acupuncture Points in Orthodontic Patients
Authors: Queiroga Raquel Porto , Segundo Aguinaldo Silva Garcez 
Published: December 2024

Abstract

Photobiomodulation and laser acupuncture are pain management treatments, offering safe, non-invasive options for patients seeking alternatives to conventional treatments. Therefore, the aim of this research is to evaluate the effects of low-level laser therapy at acupuncture points on pain mechanisms caused by orthodontic separators. For the study, 162 healthy adult volunteers over the age of 18 were selected. Orthodontic separators were installed to stimulate pain. The volunteers were divided into three groups: Group 1 received diode laser (808 nm, 100 mW) at acupuncture points for 40 seconds (4 J energy), Group 2 received diode laser (808 nm, 100 mW) on molars with orthodontic separators for 40 seconds (4 J energy), and Group 3 received a placebo at acupuncture points. The acupuncture points used were: LI4 (Hegu), EX2 (Yintang), LI6 (Pianli), LI11 (Quchi), and LU7 (Lieque). A modified Visual Analogue Scale (VAS) was used to assess pain levels. To evaluate differences in pain intensity between groups and over time, the Friedman and Kruskal-Wallis tests were used. Statistical analysis confirmed a significant difference in pain intensity between groups over time (p < 0.001). No significant difference in pain perception was observed between genders (p = 0.943). The difference between the groups that received laser therapy at acupuncture points and local points was not statistically significant (p = 0.272). It can be concluded that laser therapy at acupuncture points yields results similar to laser therapy for pain induced by the installation of orthodontic separators, with both being more effective than placebo treatment.
Extraction and Characterization of Starch from Ginger (Zingiber officinate)
Authors: Singh Anurag , yadav Mayur 
Published: December 2024

Abstract

The aim of research was to extract the starch from ginger. It contains gingerol, fat, starch and volatile oil. It is the rhizome of the plant Zingiber Officinate. Ginger is belonging to the family Zingiberaceae is an ancient Indian medicine used in several disorders. It is a popular spice with important nutraceuticals attributes is cultivated extensively in India. after extraction of starch from ginger. The obtained starch had a yield of 13%. The prepared starch was characterized by FTIR and TGA to investigate the chemical composition, thermal properties. From these findings results suggested that the ginger can be used to extract starch. Due to biodegradable and biocompatible in nature. It will be used for biodegradable film and biomedical applications.
Contact force multiscale calculation in the framework of the non-smooth dynamic approach
Authors: Cavalieri Federico José , Sánchez Eliana , Cardona Alberto 
Published: December 2024

Abstract

Smooth contact models derived from the Hertz theory are widely used in structural dynamics analysis to calculate variable-in-time forces, stresses, and deformations. However, these models require very small time steps during the period in which bodies are in contact to integrate the equations of motion, yielding in a highly time-consuming numerical solution. Furthermore, penetration between bodies is unavoidable. On the other hand, non-smooth techniques use an impact law to calculate the impulses. They arrive to a scheme with a constant time step resulting in very efficient calculations. However, these techniques do not provide a straightforward approach to calculate the variable in time contact forces that are needed to verify or design the structural components. In this work, a new methodology of calculation of impact forces that combines the impulse values obtained from non-smooth algorithms together with a local contact force law derived from continuous force models is presented. Thus, the computational time required to calculate the contact forces is reduced significantly. Several numerical examples are presented to show the robustness and performance of the proposed methodology.
Biases toward weight, diet, and exercise expressed by health science students and their professors
Authors: Clark James E. , Wiszniak Martha F. , Bicomong Ricci , Sousa Makayla , Jolivette Dalton , Sirois Emily 
Published: December 2024

Abstract

Background
Bias is a recognized to inhibit a holistic model of healthcare. Yet, little has been investigated into how bias in the educational process influences the development of bias in healthcare professionals.
Methods
344 students and professors (152 M/172 F/ 20 other) completed an electronic survey regrading ideals of diet, exercise, health, body weight, and how one obtains information for developing or modeling healthy behaviors. Responses were analyzed based on group averages,
Results
Social media appears to be the most cited source for information on lifestyle interventions. Even with awareness of social pressures to be thin, “thinnest” body was deemed to be healthiest. A greater confirmation bias was expressed in older respondents regarding advice to overweight individuals, with younger respondents being more conscious of their approach.
Conclusion
For students, biases appear to develop through combination of preconceived ideals reinforced by educators. Recommendations appear to be based on personal beliefs and projection of biases by educators and students based on personal anecdotes or over-reliance on social media for modeling of appropriate healthy behaviors and attitudes.
Understanding One Health and Zoonosis: A Bibliometric Analysis of Turkish Research and Global Perspectives (1974-2023)
Authors: DIOP samba deguene , Inci Abdullah , KIZGIN Alina Denis , DUZLU Onder , YILDIRIM Alparslan 
Published: December 2024

Abstract

Background/aim: This article aims to assess, through a bibliometric analysis, the level of understanding of the concepts of One Health and zoonosis among Turkish researchers and to find existing gaps.
Materials and methods: A bibliometric analysis was used to examine trends in research concerning "One Health," "Zoonosis," and "Zoonoses", focusing on publications originating from Türkiye and globally. Data from Scopus were gathered and analysed using VOSviewer and Rstudio software.
Results: Research interest in One Health and zoonoses has increased in Türkiye since the 2000s. Despite this growing interest, the number of articles on these topics in Türkiye remains lower than in other developed countries. The analysis revealed the interdisciplinary nature of “One Health” and “zoonosis” research, which draws on contributions from diverse academic fields in Türkiye. Academicians from different fields have made significant contributions, and the top ten most prominent authors in these fields were identified. Comparisons between Türkiye and other countries shed light on nuanced disparities. Thus, research on these concepts is distributed by field. Most of the research in Türkiye has been conducted in medical sciences, followed by immunology and veterinary sciences. Our keywords analysis showed significant differences in the concepts "One Health" and "zoonosis". In Türkiye, the “One Health” concept is associated predominantly with animals, especially felines. This term is mostly linked to zoonotic pathogens such as Toxoplasma, Anthrax, Fasciola hepatica, andEchinococcus. It also includes concepts such as epidemiology, infectious diseases, and antibiotic resistance. Beyond Turkish borders, this concept has a wider understanding and is associated with concepts such as environmental health, education, veterinary medicine, and food safety. In Türkiye, the “zoonosis” concept is linked to pathogens such as Anthrax, Fasciola hepatica, Echinoccocus, Brucella, Leishmania, and hantavirus. When the zoonosis term is analysed globally, besides the pathogens associated with Türkiye, it includes pathogens such as Ricketssia, Salmonella, Taenia solium, and Giardia. Zoonosis is also closely related to concepts such as climate change, animal welfare, and vector-borne and food-borne diseases.
Chemoselective Ligation between Acyl Hydrazines and Nitroalkanes as 1,3,4-Thiadiazoles using Elemental Sulfur
Authors: Li Jing , Wang Xiaonan , Yu Xiuwen , Qian Ruixi , Xu Si , Lear Martin , He Wanxiao 
Published: December 2024

Abstract

Substituted 1,3,4-thiadiazoles find extensive use in pharmaceutical, agricultural, and materials chemistry. The incorporation of adaptable heterocyclic pharmacophores results in tunable hybrid molecules with diverse medicinal properties. In this study, the direct coupling of primary nitroalkanes and acyl hydrazines (hydrazides) was achieved simply by the mild action of S8 and Na2S. This method now delivers wide varieties of multi-functionalized 1,3,4-thiadiazoles in excellent yields. The reaction is scalable, shows a broad substrate scope, and tolerates a wide range of functional groups. The power of this method is exemplified with over twenty acyl hydrazines, spanning a diverse range of nitroalkane substrate classes, as well as the concise and scalable synthesis of 1,3,4-thiadiazole derivatives of over ten distinct types of drugs and peptides.
Home-based digital counselling by frontline community workers for anxiety and depression in rural Pakistan: piloting mPareshan - a task-shifting primary mental health care intervention
Authors: Rabbani Fauziah , Nafis Javeria , Akhtar Samina , Siddiqui Amna , Merali Zul 
Published: December 2024

Abstract

Background
There is limited evidence that interventions for improving mental well-being can be integrated sustainably into primary health care in Pakistan. We aimed to pilot ‘mPareshan digital intervention’ locally, adapted from WHO mhGAP and delivered by trained and supervised women lay workers to learn if it was feasible and possibly effective in reducing anxiety and depression prior to proposing implementation on a larger scale.
Method
Using Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9), a baseline household survey was conducted by independent data collectors to measure anxiety and depression. We trained 72 government Lady Health Workers (LHWs) and Lady Health Supervisors (LHSs) in District Badin, Sindh for 3 days to screen and counsel adult men and women (> 18 years) with mild and moderate symptoms of anxiety and depression. Supervised by LHSs, these screen positive participants (SPs) received 6 counselling sessions by LHWs through the mPareshan app during their routine household visits. The app had interactive audio/video psychoeducation features. Severe cases of anxiety and depression were referred to nearest available mental health service.
Results
Out of the 366 individuals surveyed at baseline, 98 participants (53 men and 45 women, mean age 43.2 years) screened positive for mild and moderate anxiety and depression and were eligible for the mPareshan digital counselling intervention. 6 SPs were lost to follow up for various reasons. Of the 92 SPs who completed all 6 counselling sessions, their mean PHQ-9 score declined from 7.5 (sd 3.1) before intervention to 2.6 (sd 2.2) after intervention. Mean GAD-7 score fell from 6.6 (sd 3.0) to 2.1 (sd 2.2) after 6 sessions. No significant association between sociodemographic variables (age, gender, education, and income levels) and anxiety and depression scores was noted.
Conclusion
Preliminary evidence of a meaningful improvement in anxiety and depression was found using this locally adapted digital counselling intervention delivered by lay health workers in a rural setting of Sindh, Pakistan. There is a need to test the effectiveness of this task-shifting mental health model in an appropriately powered randomised controlled trial.
Trial Registration
ACTRN12622000989741 at the Australian New Zealand Clinical Trial Registry (https//www.anzctr.org.au/Default.aspx).
A Bibliometric Analysis of Oxidative Stress Research in Liver Cirrhosis: Trends, Hotspots, and Future Directions
Authors: Baktikulova Kristina , Kurmangaliyeva Saulesh , Kurmangaliev Kairat , Makashova Mentai , Tissin Konstantin , Madenbayeva Akzhan 
Published: December 2024

Abstract

Oxidative stress is a critical factor in the pathophysiology of liver diseases, including chronic conditions and cirrhosis. However, the scientific landscape in this field remains fragmented. This bibliometric analysis aims to systematize existing research, identify major trends, and outline emerging directions. Data from the Scopus and Web of Science databases were analyzed, with a focus on peer-reviewed publications from 1991 to 2023. The key metrics included publication counts, citation analysis, keyword co-occurrence, and thematic mapping. The results revealed substantial growth in publications on oxidative stress and liver diseases over the past two decades. Key research areas include liver fibrosis, alcohol-induced liver damage, nonalcoholic fatty liver disease (NAFLD), and the therapeutic potential of antioxidants. The United States leads research output, demonstrating active collaboration with the United Kingdom, Germany, China, and Saudi Arabia. Emerging contributors, such as India, Egypt, and Brazil, are also gaining prominence, albeit on a smaller scale. Keyword analysis identified new areas of focus, such as "mitochondrial dysfunction," "antioxidant therapy," and "redox signaling." Coauthorship networks highlight the global nature of research, with an increasing trend toward international collaboration. These findings emphasize the need to develop targeted antioxidant therapies, integrate oxidative stress biomarkers into clinical practice, and advance precision medicine approaches. This analysis offers valuable insights into the trajectory of oxidative stress research in liver diseases, providing a foundation for future investigations and clinical applications.