bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Hierarchy-of-Hypotheses Approach from a Philosophy of Science Perspective
Authors: Schurz Gerhard 
Published: August 2020

Abstract
I investigate Heger and Jeschke's account of hierarchies of hypotheses (HoHs) from a philosophy of science perspective. HoHs can be theory driven or evidence driven. Theory-driven HoHs fit well with standard representations of hierarchical theory nets (HTNs) in the philosophy of science. A disadvantage of the development of theory-driven HoHs is that they neglect hypotheses describing the effects of combinations of causes; this disadvantage can be removed by adding an additional layer of system conditions. Evidence-driven HoHs additionally include kinds of empirical tests by means of which certain hypotheses in the HoH are tested. This aspect of HoHs goes beyond standard HTNs in the philosophy of science and is highly fruitful; however, it leads to certain problems concerning the relation between causal hypotheses and empirically testable correlation claims.
Use of micronucleus assays for the prediction and detection of cervical cancer: a meta-analysis
Authors: Setayesh Tahereh , Kundi Michael , Nersesyan Armen , Stopper Helga , Fenech Michael , Krupitza Georg , Knasmüller Siegfried 
Published: August 2020

Abstract
Cervical cancer (CC) is the fourth most common cancer in women; the survival rates depend strongly on its early detection. The Pap test is the most frequently used diagnostic tool, but due to its limited sensitivity/specificity, additional screening tests are needed. Therefore, we evaluated the use of micronucleus (MN) assays with cervical cells for the prediction and diagnosis of CC. MN reflects structural and numerical chromosomal aberrations. A search was performed in Pubmed, Scopus, Thomson ISI and Google Scholar. Subsequently, meta-analyses were performed for different grades of abnormal findings in smears and biopsies from patients which were diagnosed with CC. Results of 21 studies in which findings of MN experiments were compared with data from Pap tests show that higher MN frequencies were found in women with abnormal cells that are indicative for increased cancer risks. MN frequency ratios increased in the order inflammation (2.1) &lt; ASC-US and ASC-H (3.3) &lt; LGSIL (4.4) &lt; HGSIL (8.4). Furthermore, results are available from 17 investigations in which MN were scored in smears from patients with neoplasia. MN rates increased with the degree of neoplasia [CIN 1 (4.6) &lt; CIN 2 (6.5) and CIN 3 (10.8)] and were significantly higher (8.8) in CC patients. Our meta-analysis indicates that the MN assay, which is easy to perform in combination with Pap tests, may be useful for the detection/prediction of CC. However, standardization (including definition of the optimal cell numbers and stains) and further validation is necessary before the MN test can be implemented in routine screening.
Incidence of Asymptomatic and Symptomatic Influenza Among Healthcare Workers: A Multicenter Prospective Cohort Study
Authors: Bénet Thomas , Amour Sélilah , Valette Martine , Saadatian-Elahi Mitra , Aho-Glélé Ludwig Serge , Berthelot Philippe , Denis Marie-Agnès , Grando Jacqueline , Landelle Caroline , Astruc Karine , Paris Adeline , Pillet Sylvie , Lina Bruno , Vanhems Philippe ,   AFP Study Group, Bardou Marc , Bour Jean-Baptiste , Fontana Luc , Mallaret Marie-Reine , Lupo Julien , Morand Patrice , Pothier Pierre , Pozzetto Bruno , Robert Olivier , Smolik Henri Jacques 
Published: August 2020

Abstract

Background
Influenza is an important cause of viral hospital-acquired infection involving patients, healthcare workers (HCW), and visitors. The frequency of asymptomatic influenza among HCW with possible subsequent transmission is poorly described. The objective is to determine the cumulative incidence of asymptomatic, paucisymptomatic, and symptomatic influenza among HCW.

Method
A multicenter prospective cohort study was done in 5 French university hospitals, including 289 HCW during the 2016–2017 influenza season. HCW had 3 physical examinations (time [T] 0, before epidemic onset; T.1, before epidemic peak; T.2, T.3, after epidemic peak). A blood sample was taken each time for influenza serology and a nasal swab was collected at T1 and T2 for influenza detection by polymerase chain reaction (PCR). Positive influenza was defined as either a positive influenza PCR, and/or virus-specific seroconversion against influenza A, the only circulating virus, with no vaccination record during follow-up. Symptoms were self-reported daily between T1 and T2. Cumulative incidence of influenza was stratified by clinical presentation per 100 HCW.

Results
Of the 289 HCW included, 278 (96%) completed the entire follow-up. Overall, 62 HCW had evidence of influenza of whom 46.8% were asymptomatic, 41.9% were paucisymptomatic, and 11.3% were symptomatic. Cumulative influenza incidence was 22.3% (95% confidence interval [CI]: 17.4%–27.2%). Cumulative incidence of asymptomatic influenza was 5.8% (95% CI: 3.3%–9.2%), 13.7% (95% CI: 9.9%–18.2%) for paucisymptomatic influenza, and 2.9% (95% CI: 1.3%–5.5%) for symptomatic influenza.

Conclusions
Asymptomatic and paucisymptomatic influenza were frequent among HCW, representing 47% and 42% of the influenza burden, respectively. These findings highlight the importance of systematic implementation of infection control measures among HCW regardless of respiratory symptoms from preventing nosocomial transmission of influenza.

Clinical Trials Registration
NCT02868658.
Sleep patterns and physical function in older adults attending primary health care
Authors: Arias-Fernández Lucía , Smith-Plaza Andrea M , Barrera-Castillo María , Prado-Suárez Jessica , Lopez-Garcia Esther , Rodríguez-Artalejo Fernando , Lana Alberto 
Published: August 2020

Abstract

Background
Sleep disturbances may contribute to physical function impairment among older adults.

Objective
To examine the associations between sleep quality and duration and impaired physical function among older adults.

Methods
Cross-sectional study involving 392 non-institutionalized adults aged ≥65 years, who were recruited from primary health care centres in Spain. Sleep quality and duration were assessed with the Pittsburgh Sleep Quality Index (PSQI). The FRAIL scale was used to identify physical frailty, the short physical performance battery to assess lower extremity functional impairment (LEFI) and grip strength was measured using a hand-held dynamometer to assess muscle weakness. Statistical analyses were performed with logistic regression models adjusted for potential confounders.

Results
Participants with poor sleep quality (PSQI global score ≥10) were more likely to have functional limitations; the odds ratio (95% confidence interval) was 2.90 (1.10–7.64) for physical frailty, 2.73 (1.34–5.58) for LEFI and 2.32 (1.14–4.75) for muscle weakness. Sleep quality components associated with frailty were sleep disturbances, use of sleeping medication and daytime dysfunction. The only quality component associated with LEFI was poor sleep efficiency, while subjective poor sleep quality and daytime dysfunction were linked to muscle weakness. No associations were observed between night-time sleep duration and physical function indicators.

Conclusions
Poor self-reported sleep quality, but not sleep duration, was associated with an increased frequency of physical frailty, LEFI and muscle weakness. Interventions to improve sleep quality could contribute to healthy ageing.
Nondestructive Tree Stem and Crown Volume Allometry in Hybrid Poplar Plantations Derived from Terrestrial Laser Scanning
Authors: Chianucci Francesco , Puletti Nicola , Grotti Mirko , Ferrara Carlotta , Giorcelli Achille , Coaloa Domenico , Tattoni Clara 
Published: August 2020

Abstract
Accurate and frequently updated tree volume estimates are required for poplar plantations, which are characterized by fast growth rate and short rotation. In this study, we tested the potential of terrestrial laser scanning (TLS) as a reliable method for developing nondestructive tree volume allometries in poplar plantations. The trial was conducted in Italy, where 4- to 10-year-old hybrid plantations were sampled to develop tree crown volume allometry in leaf-on conditions, tree stem volume, and height-diameter allometries in leaf-off conditions. We tested one-entry models based on diameter and two-entry models based on both diameter and height. Model performance was assessed by residual analysis. Results indicate that TLS can provide accurate models of tree stem and crown volume, with percentage of root-mean-square error of about 20 percent and 15 percent, respectively. The inclusion of height does not bring relevant improvement in the models, so that only diameter can be used to predict tree stem and crown volume. The TLS-measured stem volume estimates agreed with an available formula derived from harvesting. We concluded that TLS is a reliable method for developing nondestructive volume allometries in poplar plantations and holds great potential to enhance conventional tree inventory and monitoring.
Study Implications: Terrestrial laser scanning (TLS) is a technique that allows nondestructive measurement of the three-dimensional structure of a tree with high precision and low cost. The ability of TLS to measure both tree crown volume and tree position can be effective to test optimal spacing requirements and also to test innovative schemes such as mixed or polycyclic poplar plantations. The spatially explicit nature of TLS measurements allows better integration with different remotely sensed sensors, which can be used in combination with TLS, enabling a multiscale assessment of poplar plantation structure with different levels of detail, enhancing conventional tree inventory and supporting effective management strategies.
Is patient navigation a solution to the problem of "leaving no one behind"? A scoping review of evidence from low-income countries
Authors: Louart Sarah , Bonnet Emmanuel , Ridde Valéry 
Published: August 2020

Abstract
Patient navigation interventions, which are designed to enable patients excluded from health systems to overcome the barriers they face in accessing care, have multiplied in high-income countries since the 1990s. However, in low-income countries (LICs), indigents are generally excluded from health policies despite the international paradigm of universal health coverage (UHC). Fee exemption interventions have demonstrated their limits and it is now necessary to act on other dimensions of access to healthcare. However, there is a lack of knowledge about the interventions implemented in LICs to support the indigents throughout their care pathway. The aim of this paper is to synthesize what is known about patient navigation interventions to facilitate access to modern health systems for vulnerable populations in LICs. We therefore conducted a scoping review to identify all patient navigation interventions in LICs. We found 60 articles employing a total of 48 interventions. Most of these interventions targeted traditional beneficiaries such as people living with HIV, pregnant women and children. We utilized the framework developed by Levesque et al. (Patient-centred access to health care: conceptualising access at the interface of health systems and populations. Int J Equity Health 2013;12:18) to analyse the interventions. All acted on the ability to perceive, 34 interventions on the ability to reach, 30 on the ability to engage, 8 on the ability to pay and 6 on the ability to seek. Evaluations of these interventions were encouraging, as they often appeared to lead to improved health indicators and service utilization rates and reduced attrition in care. However, no intervention specifically targeted indigents and very few evaluations differentiated the impact of the intervention on the poorest populations. It is therefore necessary to test navigation interventions to enable those who are worst off to overcome the barriers they face. It is a major ethical issue that health policies leave no one behind and that UHC does not benefit everyone except the poorest.
Skeletal muscle regeneration in facioscapulohumeral muscular dystrophy is correlated with pathological severity
Authors: Banerji Christopher R S , Henderson Don , Tawil Rabi N , Zammit Peter S 
Published: August 2020

Abstract
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant myopathy characterized by slowly progressive skeletal muscle weakness and wasting. While a regenerative response is often provoked in many muscular dystrophies, little is known about whether a regenerative response is regularly elicited in FSHD muscle, prompting this study. For comparison, we also examined the similarly slowly progressing myotonic dystrophy type 2 (DM2). To first investigate regeneration at the transcriptomic level, we used the 200 human gene Hallmark Myogenesis list. This myogenesis biomarker was elevated in FSHD and control healthy myotubes compared to their myoblast counterparts, so is higher in myogenic differentiation. The myogenesis biomarker was also elevated in muscle biopsies from most independent FSHD, DM2 or Duchenne muscular dystrophy (DMD) studies compared to control biopsies, and on meta-analysis for each condition. In addition, the myogenesis biomarker was a robust binary discriminator of FSHD, DM2 and DMD from controls. We also analysed muscle regeneration at the protein level by immunolabelling muscle biopsies for developmental myosin heavy chain. Such immunolabelling revealed one or more regenerating myofibres in 76% of FSHD muscle biopsies from quadriceps and 91% from tibialis anterior. The mean proportion of regenerating myofibres per quadriceps biopsy was 0.48%, significantly less than 1.72% in the tibialis anterior. All DM2 muscle biopsies contained regenerating myofibres, with a mean of 1.24% per biopsy. Muscle regeneration in FSHD was correlated with the pathological hallmarks of fibre size variation, central nucleation, fibrosis and necrosis/regeneration/inflammation. In summary, the regenerative response in FSHD muscle biopsies correlates with the severity of pathology.
Who stole disarmament? History and nostalgia in nuclear abolition discourse
Authors: Egeland Kjølv 
Published: August 2020

Abstract
Influential members of the disarmament community have in recent years maintained that further progress towards the international community's nominally shared goal of a world without nuclear weapons depends on recapturing the spirit and practices of cooperation that prevailed in the late 1980s and 1990s. Proponents of abolition, in this view, should focus their efforts on revitalizing the tried and tested arms control formula that was implemented following the end of the Cold War. In this article, I argue that this call to make disarmament great again reflects unwarranted nostalgia for a past that never was, fostering overconfidence in established approaches to the elimination of nuclear weapons. Far from putting the world on course to nuclear abolition, the end of the Cold War saw the legitimation of nuclear weapons as a hedge against ‘future uncertainties’ and entrenchment of the power structures that sustain the retention of nuclear armouries. By overselling past progress towards the elimination of nuclear arms, the nostalgic narrative of a lost abolitionist consensus is used to rationalize the existing nuclear order and delegitimize the pursuit of new approaches to elimination such as the movement to stigmatize nuclear weapons and the practice of nuclear deterrence.
The future war studies community and the Chinese revolution in military affairs
Authors: Liao Kai 
Published: August 2020

Abstract
This article traces the origins and evolution of the ideas and concepts associated with the Chinese revolution in military affairs (RMA). It identifies the PLA Daily's ‘Study Military’ column and ‘Military Salon’ as core elements of a future war studies community that has been a major force advocating a forward-looking approach to military studies and defence planning since the early 1980s. It examines their studies and activities, and argues that this community was at the forefront of studying foreign military theories and ideas and introduced RMA-related concepts to China and adapted them to the Chinese context. More specifically, in the early 1980s, they contributed to the reassessing of the international security environment and shaped the Chinese leadership's threat perception, which eventually led to the shift of the People's Liberation Army's (PLA) strategic thought from preparing for imminent all-out war to peacetime army-building. In the late 1980s, they proposed major PLA-wide future war studies initiatives, which resulted in introducing the concepts of local war and high-tech wars into the PLA. They were a major intellectual force that laid the theoretical foundation for the PLA's doctrine of ‘local war under high-tech conditions’, announced in 1993, which paved the way to the RMA with Chinese characteristics.
Global–local dynamics in anti-feminist discourses: an analysis of Indian, Russian and US online communities
Authors: Rothermel Ann-Kathrin 
Published: August 2020

Abstract
Women's rights are a core part of a global consensus on human rights. However, we are currently experiencing an increasing popularity of anti-feminist and misogynist politics threatening to override feminist gains. In order to help explain this current revival and appeal, in this article I analyse how anti-feminist communities construct their collective identities at the intersection of local and global trends and affiliations. Through an in-depth analysis of representations in the collective identities of six popular online anti-feminist communities based in India, Russia and the United States, I shed light on how anti-feminists discursively construct their anti-feminist ‘self’ and the feminist ‘other’ between narratives of localized resistance to change and backlash against the results of broader societal developments associated with globalization. The results expose a complex set of global–local dynamics, which provide a nuanced understanding of the differences and commonalities of anti-feminist collective identity-building and mobilization processes across contexts. By explicitly focusing on the role of discursively produced locations for anti-feminist identity-building and providing new evidence on anti-feminist communities across three different continents, the article contributes to current discussions on transnational anti-feminist mobilizations in both social movement studies and feminist International Relations.
Meropenem population pharmacokinetics in patients with decompensated cirrhosis and severe infections
Authors: Bastida Carla , Hernández-Tejero María , Aziz Fátima , Espinosa Cristina , Sanz Miquel , Brunet Mercè , López Ester , Fernández Javier , Soy Dolors 
Published: August 2020

Abstract

Objectives
Meropenem pharmacokinetics (PK) may be altered in patients with cirrhosis, hampering target attainment. We aimed to describe meropenem PK in patients with decompensated cirrhosis and severe bacterial infections, identify the sources of PK variability and assess the performance of different dosing regimens to optimize the PK/pharmacodynamic (PD) target.

Methods
Serum concentrations and covariates were obtained from patients with severe infections under meropenem treatment. A population PK analysis was performed using non-linear mixed-effects modelling and the final model was used to simulate meropenem exposure to assess the PTA.

Results
Fifty-four patients were enrolled in the study. Data were best described by a one-compartment linear model. The estimated typical mean value for clearance (CL) was 8.35 L/h and the estimated volume of distribution (V) was 28.2 L. Creatinine clearance (CLCR) and MELD score significantly influenced meropenem CL, and acute-on-chronic liver failure (ACLF) significantly affected V. Monte Carlo simulations showed that a lower meropenem dose would be needed as CLCR decreases and as the MELD score increases. Patients with ACLF would have lower peak meropenem concentrations but similar steady-state concentrations compared with patients with no ACLF.

Conclusions
Our study identified two new covariates that influence meropenem PK in patients with decompensated cirrhosis in addition to CLCR: MELD score and ACLF. Dosing regimens are recommended to reach several PK/PD targets considering these clinical variables and any MIC within the susceptibility range.
Cell-based meat: the need to assess holistically
Authors: Faustman Cameron , Hamernik Deb , Looper Michael , Zinn Steven A 
Published: August 2020

Abstract
Proof-of-principle for large-scale engineering of edible muscle tissue, in vitro, was established with the product’s introduction in 2013. Subsequent research and commentary on the potential for cell-based meat to be a viable food option and potential alternative to conventional meat have been significant. While some of this has focused on the biology and engineering required to optimize the manufacturing process, a majority of debate has focused on cultural, environmental, and regulatory considerations. Animal scientists and others with expertise in muscle and cell biology, physiology, and meat science have contributed to the knowledge base that has made cell-based meat possible and will continue to have a role in the future of the new product. Importantly, the successful introduction of cell-based meat that looks and tastes like conventional meat at a comparable price has the potential to displace and/or complement conventional meat in the marketplace.
Anaplastic Transformation in Myxopapillary Ependymoma: A Report of 2 Cases and Review of the Literature
Authors: Gitto Lorenzo , Serinelli Serenella , Galbraith Kristyn , Williams Michael , Mirchia Kanish , Galgano Michael A , Krishnamurthy Satish , de la Roza Gustavo , Viapiano Mariano S , Walker Jamie M , Jour George , Serrano Jonathan , DeLorenzo Michael , Snuderl Matija , Richardson Timothy E 
Published: August 2020

Abstract
Myxopapillary ependymoma (MPE) is a relatively common neoplasm arising primarily in the filum terminale/lumbosacral region of the spinal cord. It is designated as a grade I tumor in the most recent WHO Classification of Tumours of the CNS, although aggressive clinical behavior can be observed, especially in cases arising in an extradural location. Anaplastic transformation in MPE is exceedingly rare with &lt;20 examples reported in the English literature, and consensus on diagnostic features and definitive grading remain to be determined. Here, we present 2 cases of recurrent MPE with anaplastic features, both of which had histology consistent with conventional MPE as well as areas with significant atypia, frequent mitotic figures, elevated Ki-67 proliferation indices (&gt;10%–50%), necrosis, and focal vascular proliferation. Targeted next-generation sequencing panels revealed no definitive pathogenic mutations or fusion proteins in either case. Copy number profiling, methylation profiling, and t-Distributed Stochastic Neighbor Embedding were performed to investigate the molecular characteristics of these tumors. To the best of our knowledge, these are the first reported cases of MPE with anaplastic features with methylation profiling data. In addition, we review the literature and discuss common histologic and molecular findings associated with anaplastic features in MPE.