bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiwavelength classification of X-ray selected galaxy cluster candidates using convolutional neural networks
Authors: Kosiba Matej , Lieu Maggie , Altieri Bruno , Clerc Nicolas , Faccioli Lorenzo , Kendrew Sarah , Valtchanov Ivan , Sadibekova Tatyana , Pierre Marguerite , Hroch Filip , Werner Norbert , Burget Lukáš , Garrel Christian , Koulouridis Elias , Gaynullina Evelina , Molham Mona , Ramos-Ceja Miriam E , Khalikova Alina 
Published: June 2020

ABSTRACT
Galaxy clusters appear as extended sources in XMM–Newton images, but not all extended sources are clusters. So, their proper classification requires visual inspection with optical images, which is a slow process with biases that are almost impossible to model. We tackle this problem with a novel approach, using convolutional neural networks (CNNs), a state-of-the-art image classification tool, for automatic classification of galaxy cluster candidates. We train the networks on combined XMM–Newton X-ray observations with their optical counterparts from the all-sky Digitized Sky Survey. Our data set originates from the XMM CLuster Archive Super Survey (X-CLASS) survey sample of galaxy cluster candidates, selected by a specially developed pipeline, the XAmin, tailored for extended source detection and characterization. Our data set contains 1707 galaxy cluster candidates classified by experts. Additionally, we create an official Zooniverse citizen science project, The Hunt for Galaxy Clusters, to probe whether citizen volunteers could help in a challenging task of galaxy cluster visual confirmation. The project contained 1600 galaxy cluster candidates in total of which 404 overlap with the expert’s sample. The networks were trained on expert and Zooniverse data separately. The CNN test sample contains 85 spectroscopically confirmed clusters and 85 non-clusters that appear in both data sets. Our custom network achieved the best performance in the binary classification of clusters and non-clusters, acquiring accuracy of 90 per cent, averaged after 10 runs. The results of using CNNs on combined X-ray and optical data for galaxy cluster candidate classification are encouraging, and there is a lot of potential for future usage and improvements.
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes
Authors: Shukla Ruchi , Mjoseng Heidi K , Thomson John P , Kling Simon , Sproul Duncan , Dunican Donncha S , Ramsahoye Bernard , Wongtawan Tuempong , Treindl Fridolin , Templin Markus F , Adams Ian R , Pennings Sari , Meehan Richard R 
Published: June 2020

Abstract
Mouse embryonic stem cells (mESCs) cultured with MEK/ERK and GSK3β (2i) inhibitors transition to ground state pluripotency. Gene expression changes, redistribution of histone H3K27me3 profiles and global DNA hypomethylation are hallmarks of 2i exposure, but it is unclear whether epigenetic alterations are required to achieve and maintain ground state or occur as an outcome of 2i signal induced changes. Here we show that ESCs with three epitypes, WT, constitutively methylated, or hypomethylated, all undergo comparable morphological, protein expression and transcriptome changes independently of global alterations of DNA methylation levels or changes in H3K27me3 profiles. Dazl and Fkbp6 expression are induced by 2i in all three epitypes, despite exhibiting hypermethylated promoters in constitutively methylated ESCs. We identify a number of activated gene promoters that undergo 2i dependent loss of H3K27me3 in all three epitypes, however genetic and pharmaceutical inhibition experiments show that H3K27me3 is not required for their silencing in non-2i conditions. By separating and defining their contributions, our data suggest that repressive epigenetic systems play minor roles in mESC self-renewal and naïve ground state establishment by core sets of dominant pluripotency associated transcription factor networks, which operate independently from these epigenetic processes.
Inactivation of the dimeric RappLS20 anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization
Authors: Crespo Isidro , Bernardo Nerea , Miguel-Arribas Andrés , Singh Praveen K , Luque-Ortega Juan R , Alfonso Carlos , Malfois Marc , Meijer Wilfried J J , Boer Dirk Roeland 
Published: June 2020

Abstract
Quorum sensing allows bacterial cells to communicate through the release of soluble signaling molecules into the surrounding medium. It plays a pivotal role in controlling bacterial conjugation in Gram-positive cells, a process that has tremendous impact on health. Intracellular regulatory proteins of the RRNPP family are common targets of these signaling molecules. The RRNPP family of gene regulators bind signaling molecules at their C-terminal domain (CTD), but have highly divergent functionalities at their N-terminal effector domains (NTD). This divergence is also reflected in the functional states of the proteins, and is highly interesting from an evolutionary perspective. RappLS20 is an RRNPP encoded on the Bacillus subtilis plasmid pLS20. It relieves the gene repression effectuated by RcopLS20 in the absence of the mature pLS20 signaling peptide Phr*pLS20. We report here an in-depth structural study of apo and Phr*pLS20-bound states of RappLS20 at various levels of atomic detail. We show that apo-RappLS20 is dimeric and that Phr*pLS20-bound Rap forms NTD-mediated tetramers. In addition, we show that RappLS20 binds RcopLS20 directly in the absence of Phr*pLS20 and that addition of Phr*pLS20 releases RcopLS20 from RappLS20. This allows RcopLS20 to bind the promotor region of crucial conjugation genes blocking their expression.
Differential metabolomic signatures of declining renal function in Types 1 and 2 diabetes
Authors: Manca Maria Laura , Solini Anna , Haukka Jani K , Sandholm Niina , Forsblom Carol , Groop Per-Henrik , Ferrannini Ele 
Published: June 2020

Abstract

Background
Chronic kidney disease (CKD) shows different clinical features in Types1 (T1D) and 2 diabetes (T2D). Metabolomics have recently provided useful contribution to the identification of biomarkers of CKD progression in either form of the disease. However, no studies have so far compared plasma metabolomics between T1D and T2D in order to identify differential signatures of progression of estimated glomerular filtration rate (eGFR) decline.

Methods
We used two large cohorts of T1D (from Finland) and T2D (from Italy) patients followed up to 7 and 3 years, respectively. In both groups, progression was defined as the top quartile of yearly decline in eGFR. Pooled data from the two groups were analysed by univariate and bivariate random forest (RF), and confirmed by bivariate partial least squares (PLS) analysis, the response variables being type of diabetes and eGFR progression.

Results
In progressors, yearly eGFR loss was significantly larger in T2D [−5.3 (3.0), median (interquartile range)mL/min/1.73 m2/year] than T1D [−3.7 (3.1) mL/min/1.73 m2/year ; P = 0.018]. Out of several hundreds, bivariate RF extracted 22 metabolites associated with diabetes type (all higher in T1D than T2D except for 5-methylthioadenosine, pyruvate and β-hydroxypyruvate) and 13 molecules associated with eGFR progression (all higher in progressors than non-progressors except for sphyngomyelin). Three of the selected metabolites (histidylphenylalanine, leucylphenylalanine, tryptophylasparagine) showed a significant interaction between disease type and progression. Only eight metabolites were common to both bivariate RF and PLS.

Conclusions
Identification of metabolomic signatures of CKD progression is partially dependent on the statistical model. Dual analysis identified molecules specifically associated with progressive renal impairment in both T1D and T2D.
Reactions to Standardized Cigarette Packs With Varying Structural Designs, and the Association With Smoking Susceptibility: A Postimplementation Cross-Sectional Survey With Never-Smoking Adolescents in Scotland
Authors: Mitchell Danielle , Critchlow Nathan , Moodie Crawford , Bauld Linda 
Published: June 2020

Abstract

Introduction
From May 20, 2017, cigarettes in the United Kingdom must be sold in standardized (plain) packaging. We explore postimplementation reactions to standardized cigarette packaging among never-smokers in Scotland, whether reactions vary in relation to permitted variations in pack structure, and whether reactions are associated with susceptibility.

Aims and Methods
A cross-sectional survey with 12–17-year-old never-smokers (n = 507) in Scotland, conducted November 2017–November 2018. Participants were shown one “regular” standardized cigarette pack (flip-top lid and straight-edged pack, similar to designs in Australia) and three standardized packs with varied pack structures (beveled-edges, slim pack, and shoulder box), which are permitted postimplementation in the United Kingdom. Participants rated each pack on eight five-point reaction measures (eg, attractiveness). Participants also indicated which pack, if any, they would choose. Smoking susceptibility was the outcome.

Results
The mean reaction scores for all four packs were mostly negative, however the shoulder box was consistently rated less negatively than the regular, slim, or beveled-edge packs. Most participants (87%) said they would not select any of the four packs, although susceptible participants were more likely to select one than nonsusceptible participants (25% vs. 7%; χ 2 = 29.70; p &lt; .001). For all four packs, not finding them off-putting was associated with susceptibility (Adjusted Odds Ratio range: 2.73–3.69), albeit only a minority of adolescents did not find each pack off-putting.

Conclusions
Adolescents have negative reactions to the standardized cigarette packs implemented in the United Kingdom, albeit permitted variations in structure can reduce the extent of negativity. Most reactions to standardized packaging had no association with susceptibility.

Implications
We provide the first empirical evidence that adolescents find the standardized cigarette packs implemented in the United Kingdom unappealing and that most pack reactions have no association with susceptibility among never-smokers, with the exception of the minority who did not think that they would put them off smoking. This suggests that the legislation is achieving one of its primary aims, to reduce the appeal of packaging. That permitted variations in pack structure (eg, shoulder boxes) somewhat reduce negative reactions suggests that the United Kingdom, and other countries introducing similar legislation, should ensure that all aspects of pack design are fully standardized.
Perspectives of Physician and Pharmacist Stewards on Successful Antibiotic Stewardship Program Implementation: A Qualitative Study
Authors: Barlam Tamar F , Childs Ellen , Zieminski Sarah A , Meshesha Tsega M , Jones Kathryn E , Butler Jorie M , Damschroder Laura J , Goetz Matthew Bidwell , Madaras-Kelly Karl , Reardon Caitlin M , Samore Matthew H , Shen Jincheng , Stenehjem Edward , Zhang Yue , Drainoni Mari-Lynn 
Published: June 2020

Abstract

Background
Antibiotic stewardship programs (ASPs) are required at every hospital regardless of size. We conducted a qualitative study across different hospital settings to examine perspectives of physician and pharmacist stewards about the dynamics within their team and contextual factors that facilitate the success of their programs.

Methods
Semistructured interviews were conducted in March–November 2018 with 46 ASP stewards, 30 pharmacists, and 16 physicians, from 39 hospitals within 2 large hospital systems.

Results
We identified 5 major themes: antibiotic stewards were enthusiastic about their role, committed to the goals of stewardship for their patients and as a public-health imperative, and energized by successful interventions; responsibilities of pharmacist and physician stewards are markedly different, and pharmacy stewards performed the majority of the day-to-day stewardship work; collaborative teamwork is important to improving care, the pharmacists and physicians supported each other, and pharmacists believed that having a strong physician leader was essential; provider engagement strategies are a critical component of stewardship, and recommendations must be communicated in a collegial manner that did not judge the provider competence, preferably through face-to-face interactions; and hospital leadership support for ASP goals and for protected time for ASP activities is critical for success.

Conclusions
The physician-pharmacist team is essential for ASPs; most have pharmacists leading and performing day-to-day activities with physician support. Collaborative, persuasive approaches for ASP interventions were the norm. Stewards were careful not to criticize or judge inappropriate antibiotic prescribing. Further research should examine whether this persuasive approach undercuts provider appreciation of stewardship as a public health mandate.
Tentorial Peeling: Surgical Extradural Navigation to Protect the Temporal Lobe in the Focused Combined Transpetrosal Approach
Authors: Vidal Claudio H F , Nicácio Joab A , Hahn Yoav , Caldas Neto Silvio S , Coimbra Caetano J 
Published: June 2020

Abstract

BACKGROUND
Transpetrosal approaches have been used for treatment of tumors in the petroclival region for many years. Injury to the temporal lobe, however, has been a potential drawback of the techniques described to date.

OBJECTIVE
To describe modifications of the transpetrosal surgical technique, which allows extradural manipulation of the temporal lobe during the focused combined transpetrosal approach. This extra layer of protection avoids mechanical brain retraction, direct trauma to the temporal lobe and disruption of the local venous structures.

METHODS
The present manuscript describes an innovative technical nuance based on the combination of the focused combined transpetrosal approach, the peeling of the dural layers of the tentorium, and the reverse peeling of the middle fossa dura mater. Ample illustrative material is provided and illustrative cases are presented.

CONCLUSION
Peeling of the dural layers of the tentorium is a promising modification of the transpetrosal approach to increase the safety of the temporal lobe manipulation.
Comprehensive photometric investigation of an active early K-type contact system—IL Cancri
Authors: Liu Nian-Ping , Sarotsakulchai Thawicharat , Rattanasoon Somsawat , Zhang Bin 
Published: June 2020

Abstract
Comprehensive photometric investigation of the early K-type contact binary IL Cnc was carried out. A few light curves from both ground-based telescopes and the Kepler space telescope were obtained (or downloaded) and then analyzed in detail. They are mostly found to be asymmetric and there are even continuously changing O’Connell effects in the light curves from Kepler K2 data, suggesting the system to be highly active. Using the Wilson–Devinney code (version 2013), photometric solutions were derived and then compared. It is found that the calculation of the mass ratio is easily affected by the spot settings. Combining the radial velocities determined from LAMOST median resolution spectral data, the mass ratio of the binary components is found to be M2/M1 = 1.76 ± 0.05. The components are in shallow contact ($f\sim 9\%$) and have a temperature difference about T2 − T1 = −280 ± 20 K. The system is demonstrated to be W-subtype, which may be a common feature of K-type contact binaries. The masses of the binary components were estimated to be $M_1\sim 0.51\, M_{\odot }$ and $M_2\sim 0.90\, M_{\odot }$. The values are in good agreement with that deduced from the parallax data of Gaia. The results suggest that the primary component lacks luminosity compared with the zero main sequence. The Hα spectral line of the primary component is found to be peculiar. Combining newly determined minimum light times with those collected from literature, the orbital period of IL Cnc is studied. It is found that the (O − C) values of the primary minima show sinusoidal variation while those of the secondary do not. The oscillation is more likely to be caused by the starspot activities, yet this assumption needs more data to support.
Assessing the current state of medical education on cannabis in Canada: Preliminary findings from Quebec
Authors: Elkrief Laurent , Belliveau Julien , D’Ignazio Tara , Simard Philippe , Jutras-Aswad Didier 
Published: June 2020

Abstract
The legalization of recreational cannabis across Canada has revealed the importance of medical education on cannabis-related topics. A recent study has indicated that Canadian physicians report a significant gap in current versus desired knowledge regarding the therapeutic use of cannabis. However, the state of education on cannabis has never been studied in Canadian medical schools. This article presents the preliminary findings of a survey conducted to understand the perceptions of Quebec’s medical students regarding cannabis-related teachings in their current curriculum. Overall, students reported very low to low levels of exposure to, knowledge of, and comfort levels with cannabis-related subjects. The majority of students reported that they felt that their medical curricula did not prepare them to face cannabis-related issues in their future practices. Strategies need to be developed for improving medical school curriculum regarding cannabis-related issues. These findings provide potential key strategies to improve curricula.
Cannabis and breastfeeding
Authors: Graves Lisa 
Published: June 2020

AbstractCannabis is one of the most commonly used substances in Canada with 15% of Canadians reporting use in 2019. There is emerging evidence that cannabis is linked to an impact on the developing brain in utero and adverse outcomes in infants, children, and adolescents. The impact of cannabis during breastfeeding has been limited by studies with small sample sizes, follow-up limited to 1 year and the challenge of separating prenatal exposure from that during breastfeeding. In the absence of high-quality evidence, health care providers need to continue to engage women in conversation about the potential concerns related to breastfeeding and cannabis use.
Le counseling auprès des adolescents et des parents au sujet du cannabis : une introduction pour les professionnels de la santé
Authors: Bélanger Richard E , Grant Christina N 
Published: June 2020

Résumé
L’usage de cannabis est fréquent chez les adolescents du Canada, mais les jeunes en reconnaissent les dangers potentiels et s’attendent de plus en plus à ce que des dispensateurs de soins bien informés leur parlent d’usage de substances psychoactives dans leur pratique quotidienne. Le présent point de pratique propose de solides outils fondés sur des données probantes pour aider les professionnels de la santé à parler d’usage de cannabis à des fins non médicales (récréatives) et des risques qui s’y associent. Les auteurs expliquent comment rendre le milieu clinique sécuritaire pour parler de substances psychoactives avec les jeunes et suggèrent des stratégies précises pour leur parler d’usage de cannabis de manière efficace et adaptée à leur développement. Conformément aux publications scientifiques récentes, ils recommandent des questionnaires de dépistage pour contribuer à structurer les échanges et déterminer quels adolescents pourraient profiter d’interventions plus spécialisées. Puisqu’un adolescent sur six qui expérimente le cannabis finit par en faire un usage abusif, l’évaluation de la volonté des adolescents à modifier leurs comportements à risque représente un aspect essentiel des soins, conjointement avec l’établissement d’objectifs complémentaires et l’aide aux familles. Enfin, des ressources pour les praticiens et les parents sont recommandées.
Tant les parents que les adolescents se préoccupent des effets et des dommages potentiels du cannabis et des autres substances psychoactives (1,2). De nombreux adolescents considèrent les professionnels de la santé comme des sources d’information fiables sur les substances psychoactives et s’attendent à ce qu’ils abordent l’usage ou les risques qui s’y associent lors des rendez-vous de santé (3). Dans le rôle de facilitateurs et de courtiers du savoir, les dispensateurs de soins (DdS) peuvent entretenir un dialogue efficace avec les jeunes et leur famille.
AAAPT Diagnostic Criteria for Acute Low Back Pain with and Without Lower Extremity Pain
Authors: Nicol Andrea L , Adams Meredith C B , Gordon Debra B , Mirza Sohail , Dickerson David , Mackey Sean , Edwards David , Hurley Robert W 
Published: June 2020

Abstract

Objective
Low back pain is one of the most common reasons for which people visit their doctor. Between 12% and 15% of the US population seek care for spine pain each year, with associated costs exceeding $200 billion. Up to 80% of adults will experience acute low back pain at some point in their lives. This staggering prevalence supports the need for increased research to support tailored clinical care of low back pain. This work proposes a multidimensional conceptual taxonomy.

Methods
A multidisciplinary task force of the ACTTION-APS-AAPM Pain Taxonomy (AAAPT) with clinical and research expertise performed a focused review and analysis, applying the AAAPT five-dimensional framework to acute low back pain.

Results
Application of the AAAPT framework yielded the following: 1) Core Criteria: location, timing, and severity of acute low back pain were defined; 2) Common Features: character and expected trajectories were established in relevant subgroups, and common pain assessment tools were identified; 3) Modulating Factors: biological, psychological, and social factors that modulate interindividual variability were delineated; 4) Impact/Functional Consequences: domains of impact were outlined and defined; 5) Neurobiological Mechanisms: putative mechanisms were specified including nerve injury, inflammation, peripheral and central sensitization, and affective and social processing of acute low back pain.

Conclusions
The goal of applying the AAAPT taxonomy to acute low back pain is to improve its assessment through a defined evidence and consensus-driven structure. The criteria proposed will enable more rigorous meta-analyses and promote more generalizable studies of interindividual variation in acute low back pain and its potential underlying mechanisms.