bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant Fluctuations Induced by Thermal Diffusion in Complex Liquids
Authors: Vailati Alberto , Baaske Philipp , Bataller Henri , Bolis Serena , Braibanti Marco , Carpineti Marina , Cerbino Roberto , Croccolo Fabrizio , Dewandel Jean-Luc , Donev Aleksandar , García-Fernández Loreto , Giavazzi Fabio , Haslinger Robert , Hens Steven , Knauer Maria , Köhler Werner , Kufner Ewald , Ortiz de Zárate José M. , Peeters Jeroen , Schwarz Christian J. , Silkina Inese , Xu Shenghua , Zapf Daniel 
Published: July 2020

AbstractThe GRADFLEX experiment of ESA has shown that under microgravity conditions a stationary thermodiffusion process is accompanied by giant non-equilibrium fluctuations with size as large as the size of the sample. In the presence of small concentration gradients, the features of the non-equilibrium fluctuations can be described by means of linearized hydrodynamics. However, the linear models are not suitable to describe most cases of applicative interest, such as fluctuations induced by large gradients and under non-stationary conditions. Moreover, presently the investigation of non-equilibrium fluctuations has mainly involved single component fluids and binary mixtures, but recently transport processes in ternary mixtures have attracted increasing interest due to the experiments performed on the International Space Station in the framework of the DCMIX project of ESA. The Giant Fluctuations (NEUF-DIX) project of ESA will investigate non-equilibrium fluctuations during diffusive processes occurring in complex multi-component mixtures, where one of the components is a macromolecule, such as a polymer, a colloid or a protein. Important objectives will be the exploration of the features of the fluctuations under non-ideal conditions, such as large gradients, transient processes, and concentrated samples, and the understanding of how the fluctuations affect the interactions between macromolecules. The project involves the development of a dedicated facility, consisting of an array of shadowgraph optical instruments working in parallel, each one equipped with a thermal gradient cell. Here we outline the design concept of the facility and the results of performance tests performed on a breadboard to evaluate the suitability of the designed instrument to carry out scientific measurements of non-equilibrium concentration fluctuations in space.
The prediction of shale gas well production rate based on grey system theory dynamic model GM(1, N)
Authors: Luo Xiaohui , Yan Xiaoqing , Chen Yusong , Yue Ming , Li Jingwei 
Published: July 2020

AbstractThe prediction of production volumes from shale gas wells is important in reservoir development. The physical parameters of a reservoir are uncertain and complex, and therefore, it is very difficult to predict the production capability of a shale gas well. An improved GM(1, N) model for shale gas well productivity prediction, focused upon the causes of prediction errors from the existing traditional GM(1, N) method, was established. By processing a data series related to the predicted data, the improved GM(1, N) model takes into account the fluctuations of the original production data, reflects the trend of the original data under the influence of relevant factors, and hence predicts more accurately the fluctuation amplitude and direction of the original data. Additionally, the proposed method has higher accuracy than the conventional GM(1, N), GM(1, 1), and MEP models. The prediction accuracy increases gradually and the relative error decreases gradually from bottom data (casing pressure at well start-up, etc.) to top data (shale gas production). Accordingly, a step-by-step prediction method could be effective in improving prediction accuracy and reflects the typical fluctuation characteristics of shale gas production.
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
Authors: Xiao Jian , Xiong Yanni , Yang Liu-Ting , Wang Ju-Qiong , Zhou Zi-Mu , Dong Le-Wei , Shi Xiong-Jie , Zhao Xiaolu , Luo Jie , Song Bao-Liang 
Published: July 2020

AbstractSterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and site-2 protease and releases a nuclear form to modulate gene expression. To search for new genes regulating cholesterol metabolism, we perform a genome-wide CRISPR/Cas9 knockout screen and find that partner of site-1 protease (POST1), encoded byC12ORF49, is critically involved in the SREBP signaling. Ablation of POST1 decreases the generation of nuclear SREBP and reduces the expression of SREBP target genes. POST1 binds S1P, which is synthesized as an inactive protease (form A) and becomes fully mature via a two-step autocatalytic process involving forms B’/B and C’/C. POST1 promotes the generation of the functional S1P-C’/C from S1P-B’/B (canonical cleavage) and, notably, from S1P-A directly (non-canonical cleavage) as well. This POST1-mediated S1P activation is also essential for the cleavages of other S1P substrates including ATF6, CREB3 family members and the α/β-subunit precursor of N-acetylglucosamine-1-phosphotransferase. Together, we demonstrate that POST1 is a cofactor controlling S1P maturation and plays important roles in lipid homeostasis, unfolded protein response, lipoprotein metabolism and lysosome biogenesis.
Hypersensitivity reactions to non-steroidal anti-inflammatory drugs: results of an Austrian cohort study
Authors: Bangerl Teresa , Zahel Brigitte , Lueger Andrea , Guenova Emmanuella , Angelova-Fischer Irena , Hoetzenecker Wolfram 
Published: July 2020

Summary
Background
Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) is the second most common cause of drug hypersensitivity. Despite the importance of NSAIDs in routine analgesia only few studies have systematically addressed the question of tolerability in hypersensitive patients.

Methods
The authors retrospectively analysed 398 patients that were treated at the Department of Dermatology, Kepler University Hospital Linz, Austria, in the period 2012–2016 with a clinical history of NSAID hypersensitivity. Skin tests (skin prick and intracutaneous tests) to common NSAIDs were performed, followed by single-blinded, placebo-controlled drug challenge with either the culprit drug or an alternative NSAID.

Results
A total of 361 patients were subjected to skin testing. Of these, 25 patients (6.3%) showed a positive reaction to the culprit drug. According to the severity of the reaction in the medical history, 87 patients were exposed orally to the culprit drug (oral provocation test, OPT) after negative skin test and 255 patients received OPT with alternative NSAIDs according to established protocols. OPT with the culprit drug resulted in hypersensitivity reactions in 12 patients (13.79%). In terms of alternative NSAID testing, the three most commonly tested drugs were lornoxicam (192 OPTs), acetaminophen (156 OPTs) and celecoxib (133 OPTs) with tolerability rates in respectively 88.54% (hypersensitivity reactions, 11.46%), 92.31% (hypersensitivity reactions, 7.69%) and 91.73% (hypersensitivity reactions, 8.27%) of cases.

Conclusion
OPT with alternative NSAIDs are useful in patients with NSAID hypersensitivity as tolerability varies between the individual substances.
Supply chain contagion and the role of industrial policy
Authors: Coveri Andrea , Cozza Claudio , Nascia Leopoldo , Zanfei Antonello 
Published: July 2020

AbstractThe COVID-19 pandemic triggered a major disruption in global value chains (GVCs) that pushed the global economy into a recession that promises to be worse than the 2008 crisis. This article illustrates the mechanisms through which the COVID-19 pandemic affected GVCs in the context of a changing configuration of the global economy. In particular, it is argued that GVCs became the main transmission channels of “economic contagion”. Finally, we posit that the pandemic provides an opportunity to revive the role of industrial policy as to govern the landslides of a world economy constantly pressured by globalization and deglobalization forces.
Comparing Residential Segregation of Migrant Populations in Selected European Urban and Metropolitan Areas
Authors: Benassi Federico , Bonifazi Corrado , Heins Frank , Lipizzi Fabio , Strozza Salvatore 
Published: July 2020

AbstractResidential segregation is a well studied subject especially after the publication of the pioneering and seminal contribution of Duncan and Duncan (Am Sociol Rev 41:210–217, 1955). Considering the theoretical and methodological advances made since then, the contribution endeavours in describing and understanding the differences in residential segregation in an international perspective using 2011 population census data. The contribution analyses the residential segregation of migrants (here foreign citizens or foreign born) usually resident in the 493 Functional Urban Areas (FUAs) of selected European Union countries. The analysis is conducted using 2011 census data on regular grid (100 mt × 100 mt) provided by the Data Challenge on ‘Integration of Migrants in Cities’ (D4I) and refers to all migrants and to two sub groups (EU 28 and non EU 28). In a first step the levels and spatial patterns of residential segregation across all FUAs of France, Germany, Ireland, Italy, Portugal, Spain, The Netherlands and the United Kingdom are analysed. Particular attention is paid to identifying differences and similarities between the FUAs, among and within the single countries. In a further analysis the relationship between the level of residential segregation in the metropolitan FUAs of the selected EU countries and contextual demographic and socio-economic factors are investigated. Results indicate that, even if, the larger metropolitan areas attract more migrants, the highest levels of residential segregation are observed in smaller urban areas. Moreover important national peculiarities emerge clearly with countries of northwestern Europe recording lower levels of residential segregation compared to the Southern European countries. Finally, residential segregation shows clear relationships with some contextual factors, especially the ones related to economic well-being and the labour market in a positive manner.
Polymorph and Polytype Identification from Individual Mica Particles Using Selected Area Electron Diffraction
Authors: Gaillot Anne-Claire , Drits Victor A. , Lanson Bruno 
Published: July 2020

AbstractDioctahedral micas are composed of two tetrahedral sheets and one octahedral sheet to form TOT or 2:1 layers. These minerals are widespread and occur with structures differing by (1) the layer stacking mode (polytypes), (2) the location of vacancies among non-equivalent octahedral sites (polymorphs), and (3) the charge-compensating interlayer cation and isomorphic substitutions. The purpose of the present study was to assess the potential of parallel-illumination electron diffraction (ED) to determine the polytype/polymorph of individual crystals of finely divided dioctahedral micas and to image their morphology. ED patterns were calculated along several zone axes close to the c*- and c-axes using the kinematical approximation for trans- and cis-vacant varieties of the four common mica polytypes (1M, 2M1, 2M2, and 3T). When properly oriented, all ED patterns have similar geometry, but differ by their intensity distribution over hk reflections of the zero-order Laue zone. Differences are enhanced for ED patterns calculated along the [001] zone axis. Identification criteria were proposed for polytype/polymorph identification, based on the qualitative distribution of bright and weak reflections. A database of ED patterns calculated along other zone axes was provided in case the optimum [001] orientation could not be found. Various polytype/polymorphs may exhibit similar ED patterns depending on the zone axis considered.
Potassium Reserves in the Clay Fraction of a Tropical Soil Fertilized for Three Decades
Authors: Firmano Ruan F. , Melo Vander Freitas , Montes Célia Regina , de Oliveira Adilson , de Castro Cesar , Alleoni Luís Reynaldo Ferracciú 
Published: July 2020

AbstractHighly weathered soils of the humid tropics generally provide a poor mineral reserve of potassium (K), but evidence has been found which indicates that even in such soils non-exchangeable forms of K can be made plant available and this warrants further investigation. The objective of this study was, therefore, to determine the extent to which K can be released from poorly available reserves over a long period of time. The focus was on an Oxisol in southern Brazil cultivated for 32 years with a rotation of soybeans (Glycine max L.), maize (Zea mays L.), wheat (Triticum aestivum L.), and oats (Avena strigosa L.) with and without K fertilization. Mineral sources of K were identified by X-ray diffraction and by sequential chemical extraction from the clay fraction. The amounts of K-bearing mineral species and the amounts of total and plant-available K were quantified, then the effects of the long-term K-fertilization regime on these values were evaluated. The clay fraction was dominated by hematite, gibbsite, and phyllosilicates such as kaolinite. These minerals were unaffected by the K deprivation in the cropping systems, but in the clay fraction the absence of K fertilization for 32 years reduced the structural order of the 2:1 phyllosilicates associated with K reserves. This effect was most prominent in the root zone of the soil. Deprivation of K for more than three decades decreased the crystallinity of 2:1 phyllosilicates, which could be better evaluated from XRD patterns after the removal of kaolinite and Fe (oxyhydr)oxides. The K-free cultivation reduced the amounts of total soil K by increasing the depletion of K from pools that typically are poorly accessible to plants.
Gangs, Methodology and Ethical Protocols: Ethnographic Challenges in Researching Youth Street Groups
Authors: Feixa Carles , Sánchez-García Jose , Brisley Adam 
Published: July 2020

AbstractGangs have been described as an episodic phenomenon comparable across diverse geographical sites, with the US gang stereotype often acting as the archetype. Mirroring this trend, academic researchers have increasingly sought to survey the global topography of gangs through positivist methodologies that seek out universal characteristics of gangs in different cultural contexts. So, research about youth street groups requires an innovative methodological approach to develop a renewed approach for the twenty-first century’s youth street groups, different from the local, coetaneous, male and face-to-face model, used to understand the twentieth century’s gangs. How can complex social forms such as street gangs be researched in the twenty-first century? Can a single ethnographic approach be shared by researchers working in entirely different cultural contexts? What novel methodological and ethical challenges emerge from such a task and how might they be resolved? This article examines the methodological perspectives of the TRANSGANG project.
Basal melting over Subglacial Lake Ellsworth and its catchment: insights from englacial layering
Authors: Ross Neil , Siegert Martin 
Published: July 2020

AbstractDeep-water ‘stable’ subglacial lakes likely contain microbial life adapted in isolation to extreme environmental conditions. How water is supplied into a subglacial lake, and how water outflows, is important for understanding these conditions. Isochronal radio-echo layers have been used to infer where melting occurs above Lake Vostok and Lake Concordia in East Antarctica but have not been used more widely. We examine englacial layers above and around Lake Ellsworth, West Antarctica, to establish where the ice sheet is ‘drawn down’ towards the bed and, thus, experiences melting. Layer drawdown is focused over and around the northwest parts of the lake as ice, flowing obliquely to the lake axis becomes afloat. Drawdown can be explained by a combination of basal melting and the Weertman effect, at the transition from grounded to floating ice. We evaluate the importance of these processes on englacial layering over Lake Ellsworth and discuss implications for water circulation and sediment deposition. We report evidence of a second subglacial lake near the head of the hydrological catchment and present a new high-resolution bed DEM and hydropotential model of the lake outlet zone. These observations provide insight into the connectivity between Lake Ellsworth and the wider subglacial hydrological system.
Clinical and Ethical Considerations in Allocation of Ventilators in an Influenza Pandemic or Other Public Health Disaster: A Comparison of the 2007 and 2015 New York State Ventilator Allocation Guidelines
Authors: Han Susie A. , Koch Valerie Gutmann 
Published: July 2020

ABSTRACTObjectives:During an influenza or coronavirus disease 2019 (COVID-19) pandemic that results in acute respiratory distress, the number of available ventilators will not meet demand. In 2007, the New York State Task Force on Life and the Law and Department of Health released draft Guidelines for ethical allocation of ventilators for adults. In 2015, updated guidelines were released to ensure that: (1) revisions reflect the public’s values and (2) the triage protocol is substantiated by evidence-based clinical data. We summarize the development and content of the 2015 Guidelines compared with the 2007 version, emphasizing new/revised aspects of the ethical considerations and clinical protocol.Methods:We compared the 2007 and 2015 guidelines, with particular emphasis on the ethical issues and clinical protocols.Results:The 2015 Guidelines retained much of the ethical and clinical framework of the 2007 draft. The triage protocol was revised using evidence-based clinical data. Patients with the highest likelihood of short-term survival with ventilator therapy have priority access. Protocol consists of exclusion criteria, the sequential organ failure assessment (SOFA) score, and periodic clinical assessments. Guidance is provided on secondary triage criteria. Other forms of medical intervention/palliative care and review of triage decisions are discussed.Conclusions:The 2015 Guidelines reflect advances in medicine and societal values and provide an evidenced-based framework to save the most lives. The framework could be adapted in other emergencies, such as the COVID-19 pandemic, that require ventilators.
Involvement of NLRP3 inflammasome in schizophrenia-like behaviour in young animals after maternal immune activation
Authors: Ventura Letícia , Freiberger Viviane , Thiesen Vinicius B. , Dias Paula , Dutra Matheus L. , Silva Bruna B. , Schlindwein Aline D. , Comim Clarissa M. 
Published: July 2020

AbstractObjective:To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA).Methods:To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. When the animals completed 7, 14 and 45 postnatal days, they were killed and the whole brain was dissected for biochemical analysis. Animals with 45 postnatal days were submitted to behavioural tests of locomotor activity, social interaction and stereotyped movements.Results:It was observed that the animals presented schizophrenia-like behaviour at 45 postnatal days associated with the increase of NLRP3 inflammasome expression and IL-1β levels on 7, 14 and 45 postnatal days.Conclusion:This study shows that MIA may be associated with a schizophrenia-like behaviour. This behaviour can be induced to a neuroinflammatory profile in the brain. These evidences may base future studies on the relationship between neuroinflammation and psychiatric disorders.
Effects of dietary grapeseed extract on performance, energy and nitrogen balance as well as methane and nitrogen losses of lambs and goat kids
Authors: Sinz Susanne , Leparmarai Paul Taipa , Liesegang Annette , Ortmann Sylvia , Kreuzer Michael , Marquardt Svenja 
Published: July 2020

AbstractThe influence of phenol-rich dietary grapeseed extract on performance, energy and N balance and methane production was determined in sixteen lambs and thirteen goat kids (body weight 20·5 and 19·0 kg, 2 months of age, day 1 of study). Half of the animals received a concentrate containing grapeseed extract, and the others received concentrate without grapeseed extract (total extractable phenols analysed 27 v. 9 g/kg dietary DM; concentrate and hay 1:1). Diets were fed for 7 weeks with 1 week for determining intake, excretion and gaseous exchange in metabolism crates and respiration chambers. Overall, there was an adverse effect of the phenolic diet on apparent N digestibility and body N retention. Faecal N loss as proportion of N intake increased while urinary N loss declined. Relative to N intake, total N excretion was higher and body N retention lower in goat kids than lambs. Diets and animal species had no effect on methane emissions. The saliva of the goat kids had a higher binding capacity for condensed tannins (CT). Goat kids on the phenolic diet had higher CT concentrations in faeces and excreted more CT compared with the lambs (interaction species × diet P < 0·001). The lambs had overall higher (P < 0·001) urinary phenol concentrations than the goat kids (2·19 v. 1·48 g/l). The negative effect on body N retention and lack of effect on methane emissions make the use of the extract in the dosage applied not appealing. Species differences need to be considered in future studies.
Effect of oral or intragastric delivery of the bitter tastant quinine on food intake and appetite sensations: a randomised crossover trial
Authors: Klaassen Tim , Keszthelyi Daniel , Alleleyn Annick M. E. , Wilms Ellen , Bast Aalt , Masclee Adrian A. M. , Troost Freddy J. 
Published: July 2020

AbstractStimulation of gastrointestinal taste receptors affects eating behaviour. Intraduodenal infusion of tastants leads to increased satiation and reduced food intake, whereas intraileal infusion of tastants does not affect eating behaviour. Currently, it is unknown whether oral- or intragastric administration of tastants induces a larger effect on eating behaviour. This study investigated the effects of oral- and/or intragastric administration of quinine on food intake, appetite sensations and heart rate variability (HRV). In a blinded randomised crossover trial, thirty-two healthy volunteers participated in four interventions with a 1-week washout: oral placebo and intragastric placebo (OPGP), oral quinine and intragastric placebo (OQGP), oral placebo and intragastric quinine (OPGQ) and oral quinine and intragastric quinine (OQGQ). On test days, 150 min after a standardised breakfast, subjects ingested a capsule containing quinine or placebo and were sham-fed a mixture of quinine or placebo orally. At 50 min after intervention, subjects received an ad libitum meal to measure food intake. Visual analogue scales for appetite sensations were collected, and HRV measurements were performed at regular intervals. Oral and/or intragastric delivery of the bitter tastant quinine did not affect food intake (OPGP: 3273·6 (sem 131·8) kJ, OQGP: 3072·7 (sem 132·2) kJ, OPGQ: 3289·0 (sem 132·6) kJ and OQGQ: 3204·1 (sem 133·1) kJ, P = 0·069). Desire to eat and hunger decreased after OQGP and OPGQ compared with OPGP (P < 0·001 and P < 0·05, respectively), whereas satiation, fullness and HRV did not differ between interventions. In conclusion, sole oral sham feeding with and sole intragastric delivery of quinine decreased desire to eat and hunger, without affecting food intake, satiation, fullness or HRV.