bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High Prevalence of Autism Spectrum Disorder in Preschool Children in an Immigrant, Multiethnic Population in Sweden: Challenges for Health Care
Authors: Linnsand Petra , Gillberg Christopher , Nilses Åsa , Hagberg Bibbi , Nygren Gudrun 
Published: June 2020

AbstractThis study examines the prevalence of autism spectrum disorder (ASD) in preschool children in an immigrant population. Possible risk factors for ASD and individual needs for the children and their families are described, as well as implications for health care. The estimated minimum prevalence for ASD in the area was 3.66% for children aged 2–5 years. Multiple risk factors and extensive individual needs for the children and their families were observed. The high prevalence of ASD and the plethora of needs in immigrant communities pose challenges for health care. A coordinated health care system is necessary to meet the many and individual needs.
Concurrent optimization of process parameters and product design variables for near net shape manufacturing processes
Authors: Marini Daniele , Corney Jonathan R. 
Published: June 2020

AbstractThis paper presents a new systematic approach to the optimization of both design and manufacturing variables across a multi-step production process. The approach assumes a generic manufacturing process in which an initial near net shape (NNS) process is followed by a limited number of finishing operations. In this context the optimisation problem becomes a multi-variable problem in which the aim is to optimize by minimizing cost (or time) and improving technological performances (e.g. turning force). To enable such computation a methodology, named conditional design optimization (CoDeO) is proposed which allows the modelling and simultaneous optimization of process parameters and product design (geometric variables), using single or multi-criteria optimization strategies. After investigation of CoDeO’s requirements, evolutionary algorithms, in particular Genetic Algorithms, are identified as the most suitable for overall NNS manufacturing chain optimization The CoDeO methodology is tested using an industrial case study that details a process chain composed of casting and machining processes. For the specific case study presented the optimized process resulted in cost savings of 22% (corresponding to equivalent machining time savings) and a 10% component weight reduction.
NMR quality control of fragment libraries for screening
Authors: Sreeramulu Sridhar , Richter Christian , Kuehn Till , Azzaoui Kamal , Blommers Marcel Jules José , Del Conte Rebecca , Fragai Marco , Trieloff Nils , Schmieder Peter , Nazaré Marc , Specker Edgar , Ivanov Vladimir , Oschkinat Hartmut , Banci Lucia , Schwalbe Harald 
Published: June 2020

AbstractFragment-based screening has evolved as a remarkable approach within the drug discovery process both in the industry and academia. Fragment screening has become a more structure-based approach to inhibitor development, but also towards development of pathway-specific clinical probes. However, it is often witnessed that the availability, immediate and long-term, of a high quality fragment-screening library is still beyond the reach of most academic laboratories. Within iNEXT (Infrastructure for NMR, EM and X-rays for Translational research), a EU-funded Horizon 2020 program, a collection of 782 fragments were assembled utilizing the concept of “poised fragments” with the aim to facilitate downstream synthesis of ligands with high affinity by fragment ligation. Herein, we describe the analytical procedure to assess the quality of this purchased and assembled fragment library by NMR spectroscopy. This quality assessment requires buffer solubility screening, comparison with LC/MS quality control and is supported by state-of-the-art software for high throughput data acquisition and on-the-fly data analysis. Results from the analysis of the library are presented as a prototype of fragment progression through the quality control process.
Comparison of the third-generation Japanese ocean flux data set J-OFURO3 with numerical simulations of Typhoon Dujuan (2015) traveling south of Okinawa
Authors: Wada Akiyoshi , Tomita Hiroyuki , Kako Shin’ichiro 
Published: June 2020

AbstractInsufficient in situ observations in high winds make it difficult to verify climatological data sets and the results of tropical cyclone (TC) simulations. Reliable data sets are necessary for developing numerical models that predict TCs more accurately. This study attempted to compare the third-generation Japanese Ocean Flux Data Sets with Use of Remote-Sensing Observations (J-OFURO3) data, with TC simulations conducted by a 2 km mesh coupled atmosphere-wave-ocean model. This is a case study of Typhoon Dujuan (2015) and the area of approximately 20̊N, 130̊E, south of Okinawa, was selected. The comparison reveals that J-OFURO3 data are reliable for verifying the atmospheric and oceanic components of TC simulations with two different initial sea surface temperature (SST) conditions, although the blank area remains within the inner core area for air temperature, specific humidity, and latent heat flux owing to issues with the construction method. Simulated maximum surface wind speeds (MSWs) are significantly correlated with J-OFURO3 MSWs. The asymmetrical distribution of simulated surface wind speeds within the inner core area can be reproduced well in the J-OFURO3 data set. In terms of the oceanic response to the TC, TC-induced sea surface cooling was reproduced well in the J-OFURO3 data set and is consistent with the simulation results. Unlike simulated SST, simulated surface wind speeds, surface air temperature, and surface specific humidity are still inconsistent with the J-OFURO3 data, even when the J-OFURO3 SST is used as the initial condition. New algorithms, more satellite data used, and model improvement are expected in the future.
Real-time multibody modeling and simulation of a scaled bogie test rig
Authors: Shrestha Sundar , Spiryagin Maksym , Wu Qing 
Published: June 2020

AbstractIn wheel–rail adhesion studies, most of the test rigs used are simplified designs such as a single wheel or wheelset, but the results may not be accurate. Alternatively, representing the complex system by using a full vehicle model provides accurate results but may incur complexity in design. To trade off accuracy over complexity, a bogie model can be the optimum selection. Furthermore, only a real-time model can replicate its physical counterpart in the time domain. Developing such a model requires broad expertise and appropriate software and hardware. A few published works are available which deal with real-time modeling. However, the influence of the control system has not been included in those works. To address these issues, a real-time scaled bogie test rig including the control system is essential. Therefore, a 1:4 scaled bogie roller rig is developed to study the adhesion between wheel and roller contact. To compare the performances obtained from the scaled bogie test rig and to expand the test applications, a numerical simulation model of that scaled bogie test rig is developed using Gensys multibody software. This model is the complete model of the test rig which delivers more precise results. To exactly represent the physical counterpart system in the time domain, a real-time scaled bogie test rig (RT-SBTR) is developed after four consecutive stages. Then, to simulate the RT-SBTR to solve the internal state equations and functions representing the physical counterpart system in equal or less than actual time, the real-time simulation environment is prepared in two stages. To such end, the computational time improved from 4 times slower than real time to 2 times faster than real time. Finally, the real-time scaled bogie model is also incorporated with the braking control system which slightly reduces the computational performances without affecting real-time capability.
An estimation of distribution algorithm with branch-and-bound based knowledge for robotic assembly line balancing
Authors: Sun Bin-qi , Wang Ling 
Published: June 2020

AbstractRobotic assembly lines are widely used in manufacturing industries. The robotic assembly line balancing (RALB) problem aims to balance the workloads among different workstations and optimize the assembly line efficiency. This paper addresses a particular type of RALB problem, which minimizes the assembly line cycle time by determining the task and robot assignment in each workstation under precedence constraints. To solve the problem, we present an effective hybrid algorithm fusing the estimation of distribution algorithm and branch-and-bound (B&B) based knowledge. A problem-specific probability model is designed to describe the probabilities of each task being assigned to different workstations. Based on the probability model, an incremental learning method is developed and a sampling mechanism with B&B based knowledge is proposed to generate new feasible solutions. The fuse of B&B based knowledge is able to reduce the search space of EDA while focusing the search on the promising area. To enhance the exploitation ability, a problem-specific local search is developed based on the critical workstation to further improve the quality of elite solutions. The computational complexity of the proposed algorithm is analyzed, and the effectiveness of the B&B based knowledge and the problem-specific local search is demonstrated through numerical experiments. Moreover, the performance of the proposed algorithm is compared with existing algorithms on a set of widely-used benchmark instances. Comparative results demonstrate the effectiveness and efficiency of the proposed algorithm.
Differential forms on hyperelliptic curves with semistable reduction
Authors: Kunzweiler Sabrina 
Published: June 2020

AbstractLetCbe a hyperelliptic curve over a local fieldKwith odd residue characteristic, defined by some affine Weierstraß equation$$y^2=f(x)$$y2=f(x). We assume thatChas semistable reduction and denote by$${\mathcal {X}}\rightarrow \text {Spec}\, {\mathcal {O}}_K$$X→SpecOKits minimal regular model with relative dualising sheaf$$\omega _{{\mathcal {X}}/ {\mathcal {O}}_K}$$ωX/OK. We show how to directly read off a basis for$$H^0({\mathcal {X}},\omega _{{\mathcal {X}}/{\mathcal {O}}_K})$$H0(X,ωX/OK)from the cluster picture of the roots off. Furthermore we give a formula for the valuation of$$\lambda $$λsuch that$$\lambda \cdot \frac{dx}{2y} \wedge \ldots \wedge x^{g-1}\frac{dx}{2y}$$λ·dx2y∧…∧xg-1dx2yis a generator for$$\det H^0({\mathcal {X}},\omega _{{\mathcal {X}}/{\mathcal {O}}_K})$$detH0(X,ωX/OK).
The real impact of colonic transit time and anorectal manometry in the diagnosis of adult patients with chronic constipation
Authors: Quaresma Abel Botelho , Baptistella Antuani Rafael , Rossoni Carina 
Published: June 2020

Abstract
Introduction Anorectal physiology tests are indicated for patients who have refractory symptoms of constipation, but the best sequence of investigation remains controversial.
Objective To evaluate the influence of colonic transit time and anorectal manometry in the diagnosis of chronic constipation in adults.
Method This was a study of adult patients with constipation at a private clinic in a city in southern Brazil, from January 1, 2009 to December 31, 2018. Those who showed warning signs were referred for colonoscopy and those with any anatomical alterations were excluded. The patients received 10 g of psyllium and those who remained symptomatic after three weeks were referred for functional assessment with colonic transit time (CTT). Those who presented outlet obstruction in the colonic transit time were referred to anorectal manometry.
Results Of the 889 adult patients surveyed, 227 were included. Of the 216 who completed the study, 167 responded to primary treatment. Forty-nine underwent CTT. In these, 16 had normal colonic transit time and 33 were altered. In those with altered colonic transit time, eight had a pattern of colonic inertia and 25 had an obstruction pattern. The 25 patients with an outlet obstruction pattern underwent anorectal manometry. Eighteen had signs of paradoxical contracture of the puborectal muscle (PPRC) and seven did not.
Conclusion This study concluded that anorectal physiology exams contribute to the diagnosis of constipation, often changing the behavior. These exams should be performed whenever the patient does not respond to hygienic changes and fiber replacement.
Impact of early eyelid weight placement on the development of synkinesis and recovery in patients with idiopathic facial paralysis
Authors: Parsa Keon M. , Rieger Caroline , Khatib Dara , White Jennifer R. , Barth Jodi , Zatezalo Chad C. , Reilly Michael J. 
Published: June 2020

PurposeDetermine the impact of upper eyelid weight placement at 3 months post onset of idiopathic facial paralysis (IFP) on the recovery of facial function in patients with lagophthalmos.MethodsThis is a retrospective review of patients with incomplete recovery of IFP—defined as a Sunnybrook Facial Grading Scale (FGS) score of less than 100, 3 months after onset. Only patients with FGS and Facial Clinimetric Evaluation (FaCE) scores recorded at 3 and 12 months were included. Patients were categorized into 3 groups: Group A, lagophthalmos with eyelid weight placement; Group B, lagophthalmos without eyelid weight placement; Group C, complete eye closure (CEC) without eyelid weight placement. The eye comfort domain and composite score of the FaCE questionnaire were analyzed. Voluntary eye closure, synkinesis with eye closure, overall synkinesis and the composite score of the FGS were also analyzed. Paired two‐tailed t‐test was used to evaluate the data comparing the 3 and 12 month FaCE and FGS scores within and between the 3 groups.ResultsThe change in composite FGS score significantly increased from month 3 to month 12 in Group A as compared to Group B (37 vs 4.25, P = 0.01). While Group A had significantly lower eye comfort (−12.5, P = 0.01), voluntary eye closure (−1.75, P = 0.05) and overall FGS scores (−28.75, P = 0.04) at 3 months compared to those in Group C, there were no differences between these two groups at 12 month follow‐up.ConclusionsFor patients with lagophthalmos at 3 months, early eyelid weight placement may lead to improved facial function at 12 months.
The Assessment and Prediction of Prospective Memory after Stroke
Authors: Hogan Christy , Cornwell Petrea , Fleming Jennifer , Shum David H. K. 
Published: June 2020

AbstractObjective:Prospective memory (PM) is the memory used when intentions are to be carried out in the future. Little research has been conducted examining PM after stroke. This study aimed to determine if PM is impaired after stroke through comparison of individuals with stroke to healthy controls. Additionally, it aimed to explore the predictors of PM performance post-stroke.Method:Twenty-eight individuals with stroke and 27 neurologically healthy controls completed the Cambridge Prospective Memory Test (CAMPROMPT), 2 self-report PM questionnaires, and multiple cognitive measures.Results:Individuals with stroke performed significantly lower on both event- and time-based PM than controls on the CAMPROMPT, indicating PM impairment. Event-based PM after stroke was significantly predicted by age, retrospective memory (RM), and global cognitive function, whereas time-based PM was only predicted by the metacognitive skill of note-taking. Age and note-taking predicted time-based PM for controls, whereas only age predicted event-based PM for control participants.Conclusions:The findings of this study have helped to confirm that PM impairment does exist after stroke, particularly when using a standardised PM measure. Furthermore, PM impairment may be predicted by variables, such as age, strategy use, RM, and cognitive ability.
Understanding blockchain for insurance use cases
Authors: Popovic D. , Avis C. , Byrne M. , Cheung C. , Donovan M. , Flynn Y. , Fothergill C. , Hosseinzadeh Z. , Lim Z. , Shah J. 
Published: June 2020

Abstract
Insurance industry practitioners have deep knowledge of their industry, but there is a lack of a simple-to-understand, practical blueprint on applying distributed ledger technology solutions, including blockchain. This paper provides a practical guide for actuaries, risk professionals, insurance companies and their Boards on blockchain, including an education piece to provide an understanding of the technology. Examples of real-world applications and use cases in insurance are provided to illustrate the capability of the technology. The current risks and challenges in adopting the technology are also considered. Finally, a checklist of issues to consider in adopting a blockchain solution for insurance business problems is provided.
Controls on Primary Productivity in the Eastern Equatorial Pacific, East of the Galapagos Islands, During the Penultimate Deglaciation
Authors: Quirós‐Collazos Lucía , Calvo Eva , Schouten Stefan , van der Meer Marcel T. J. , Rodrigo‐Gámiz Marta , Pena Leopoldo D. , Cacho Isabel , Pelejero Carles 
Published: June 2020

AbstractModern biogeochemical conditions of the Eastern Equatorial Pacific (EEP) region are characterized by high macronutrient concentrations but low phytoplankton abundance due to both iron and silicic acid limitation. Since primary producers significantly impact the global carbon cycle, paleoproductivity in relation to climate change and nutrient availability in this region has been a topic of a number of studies. However, the complex dynamics of this region, especially east of the Galapagos Islands, has led to some discrepancies when linking reconstructed paleoproductivity with potential mechanisms for higher primary productivity. Here we focus on reconstructing primary productivity of haptophyte algae and diatoms, as well as continental material input, sea surface salinity, and sea surface temperature, and compare these reconstructions with existing records for the period comprised between 150 and 110 ka (the penultimate deglaciation period) with the aim to understand the mechanisms that most significantly influence phytoplankton growth over the EEP region east of the Galapagos Islands. Our results suggest enhanced upwelling in the EEP system during the penultimate deglaciation and increased phytoplankton abundance mainly as the result of both the increasing influence of nutrient‐rich Southern Ocean sourced waters through the Equatorial Undercurrent and a higher input of iron through atmospheric deposition. The highest phytoplankton abundances recorded at the study site during the penultimate deglaciation also suggest that maximum input of nutrients might have occurred during the millennial‐scale event Heinrich Event 11 in the North Atlantic as a result of global atmospheric and oceanic reorganizations.
Subseasonal Prediction of Land Cold Extremes in Boreal Wintertime
Authors: Xiang Baoqiang , Sun Y. Qiang , Chen Jan‐Huey , Johnson Nathaniel C. , Jiang Xianan 
Published: June 2020

AbstractSubseasonal climate prediction has emerged as a top forecast priority but remains a great challenge. Subseasonal extreme prediction is even more difficult than predicting the time‐mean variability. Here we show that the wintertime cold extremes, measured by the frequency of extreme cold days (ECDs), are skillfully predicted by the European Centre for Medium‐Range Weather Forecasts (ECMWF) model 2–4 weeks in advance over a large fraction of the Northern Hemisphere land region. The physical basis for such skill in predicting ECDs is primarily rooted in predicting a small subset of leading empirical orthogonal function (EOF) modes of ECDs identified from observations, including two modes in Eurasia (North Atlantic Oscillation and Eurasia Meridional Dipole mode) and three modes in North America (North Pacific Oscillation, Pacific‐North America teleconnection mode, and the North America Zonal Dipole mode). It is of interest to note that these two modes in Eurasia are more predictable than the three leading modes in North America mainly due to their longer persistence. The source of predictability for the leading EOF modes mainly originates from atmospheric internal modes and the land‐atmosphere coupling. All these modes are strongly coupled to dynamically coherent planetary‐scale atmospheric circulations, which not only amplify but also prolong the surface air temperature anomaly, serving as a source of predictability at subseasonal timescales. The Eurasian Meridional Dipole mode is also tied to the lower‐boundary snow anomaly, and the snow‐atmosphere coupling helps sustain this mode and provides a source of predictability.
Exhumation of the High‐Pressure Tsäkkok Lens, Swedish Caledonides: Insights From the Structural and White Mica 40Ar/39Ar Geochronological Record
Authors: Barnes C. J. , Jeanneret P. , Kullerud K. , Majka J. , Schneider D. A. , Bukała M. , Klonowska I. 
Published: June 2020

AbstractIntegrated structural, geochemical, and geochronological investigations were conducted on metasedimentary rocks in the eclogite‐bearing Tsäkkok Lens of the Seve Nappe Complex (Scandinavian Caledonides) to resolve its exhumation history. Three deformation events are defined. D1 is likely related to the prograde to peak‐metamorphic stages, represented by a locally preserved S1. D2 resulted in vertical shortening and is defined by a pervasive S2 and cm‐/m‐scale F2 closed folds. D2 terminated with Scandian thrusting, which emplaced the overlying Köli Nappe Complex. D3 records NE‐SW shortening and constitutes m‐/km‐scale F3 open folds that deformed the Tsäkkok Lens and Köli Nappe Complex together. In situ white mica 40Ar/39Ar geochronology was conducted on select metasedimentary samples possessing S1 or S2 to resolve the timing of exhumation. Postdecompression cooling of the Tsäkkok Lens is best recorded by samples containing S1 or S2 that yield homogeneous white mica chemistry and 40Ar/39Ar dates. The timing of cooling is resolved to 477.2 ± 4.1 Ma (S1) and 475.3 ± 3.5 Ma (S2). Vertical shortening of the lens during exhumation may have proceeded until 458.1 ± 9.0 Ma. Later‐stage deformation during Scandian thrusting penetrated the Tsäkkok Lens at 429.9 ± 9.0 Ma, or younger. This resulted in noncoaxial deformation of the metasedimentary rocks, producing heterogeneous white mica chemistry and partially reset the older 40Ar/39Ar cooling record. Temperatures for deformation are resolved to the upper greenschist‐lower amphibolite facies. Altogether, the Tsäkkok Lens records rapid exhumation from eclogite‐facies conditions to midcrustal depths or shallower, followed by emplacement of the overlying Köli Nappe Complex.
Sestrin2 inhibits YAP activation and negatively regulates corneal epithelial cell proliferation
Authors: Lee Ji-Su , Park Hwan-Woo , Cho Kyong Jin , Lyu Jungmook 
Published: June 2020

AbstractCorneal wound healing is essential for the maintenance of corneal integrity and transparency and involves a series of physiological processes that depend on the proliferation of epithelial cells. However, the molecular mechanisms that control corneal epithelial cell proliferation are poorly understood. Here, we show that Sestrin2, a stress-inducible protein, is downregulated in the corneal epithelium during wound healing and that the proliferation of epithelial basal cells is enhanced in Sestrin2-deficient mice. We also show that YAP, a major downstream effector of the Hippo signaling pathway, regulates cell proliferation during corneal epithelial wound repair and that Sestrin2 suppresses its activity. Moreover, increased levels of reactive oxygen species in the Sestrin2-deficient corneal epithelium promote the nuclear localization and dephosphorylation of YAP, activating it to enhance the proliferation of corneal epithelial cells. These results reveal that Sestrin2 is a negative regulator of YAP, which regulates the proliferative capacity of basal epithelial cells, and may serve as a potential therapeutic target for corneal epithelial damage.