bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Updated Review on Nanoparticle Based Approach for Nanogel Drug Delivery System
Authors: Chouhan Chandrika , Rajput Rudra Pratap Singh , Sahu Rishabh , Verma Poonam , Sahu Suman 
Published: October 2020

Nanocomposite hydrogels or nanogels (a nanoparticles composed of a hydrogel) are nanomaterial filled, swollen nanosized networks of deliquescent or amphiphilic compound chains. It may be developed by drug - polymer interactions and to create 3D advanced networks. Nanogel may be ready by many strategies just like the particle gelation, Inverse mini emulsion, Dispersion, Chemical cross linking, fabrication of biopolymers and so on. It can be characterized by SEM, DSC, FTIR, Drug content, Particle size, Zeta potential and drug efficiency. Further, it can be evaluated by in vitro drug release and in vivo study in suitable animal modeling. In this review article, we have focused on basic methodology of nanogels, evaluation terms, their application in industry with future prospects for the researchers.
Keywords: Nanogel; methods of nanogel preparation; evaluation parameters and their applications.
The Pharmacogenetics of Cytochrome P-450 and its Effect on Drug Metabolism
Authors: BEREWELA DIA AHAK M 
Published: October 2020

Cytochrome P-450 (CYP-450) enzyme plays an essential role in the oxidation of most drugs, and thus it can affect the toxicity and efficacy of many medications. Factors that influence the function and presence of cytochrome have a key impact on the outcomes of therapy. More specifically, characteristics of cytochrome pharmacogenetics and procedures of cytochrome enzymes induction and inhibition can greatly influence the rate of drug biotransformation and the rate of elimination. So, an understanding of genetic variants which are associated with drug responses and illnesses could improve and enhance the outcome of treatment. Clinical data in genetic tests may be useful in order to develop methods for assessing genetic risks. Positively, genetic tests for monogenic sicknesses have already proven to be a useful test and any changes may trigger a new field of personalized drug. This review will look at the influence of pharmacogenetics in drug metabolism and the importance of using personal genetic data in achieving optimal therapy and in preventing any possible adverse effects.
Keywords: Pharmacogenetics, Biotransformation, CYP-450
Exploring Recent Advances in Nanotherapeutics
Authors: Rao Monica RP , Sonawane Ashwini , Sapate Sharwari , Abhang Kshitija 
Published: October 2020

Nanotechnology is a rapidly expanding field, encompassing the development of materials in a size range of 5-200 nanometers (nm). The applications of nanotechnology to drug delivery opened the floodgates to create novel therapeutics and diagnostics which have changed the landscape of pharmaceutical and biotechnological industries. Advances in nanotechnology are being utilized in medicine for therapeutic drug delivery and treatment of various diseases and disorders. The biodegradable nanoparticle/nanocarriers, in which drug is dissolved and entrapped are specially designed to absorb the drug and to protect it against chemical and enzymatic degradation. The important role to design these nanostructures as a delivery system is to release pharmacologically active molecules for site-specific action with an accurate dose. In recent times, several biodegradable polymeric nanostructures have been developed with an innate capacity to target specific organs/tissue to deliver the drug. Nanoparticulate drug delivery systems use polymers or lipids as carriers for drugs. Newer polymers engineered to achieve temporal and spatial drug delivery form the mainstay of these systems. In nanotechnology, being tiny molecules of immunotherapeutic have many advantages over biological drugs regarding complexity, tissue penetration, manufacturing cost, stability and shelf life, which is one of dominating therapy in the current research field. The present review gives details about the recent developments of nanostructure drug delivery systems and their applications.
Keywords: liposomes, polymeric micelles, gold nanoparticles, superparamagnetic nanoparticles, solid lipid nanoparticles, aptamers, quantum dots.
Scientific Baseline Information for the Potential Use of Hibiscus surattensis L against Malaria: Phytochemistry and Biological Studies
Authors: TIKO Gerard Hodevé , MEDJIGBODO Adandé , ADAMOU Rafiou , AMOUSSA Abdou Madjid Olatoundé , DJOGBENOU Luc Salako , LAGNIKA Latifou 
Published: October 2020

Background and aim: Hibiscus surattensis L. is a medicinal plant widely used traditionally in Benin to treat malaria. This study was designed to investigate antiplasmodial activity, hemolytic power, acute toxicity, antioxidant activity and phytochemical content of H. surattensis.
Methodology: Bioassay-guided isolation approach was adopted and extracts and fractions collected were continuously tested in vitro against Chloroquine-sensitive and field isolate strains of Plasmodium falciparum by immune-dosage of Plasmodium lactate dehydrogenase. Hemolytic effect and acute toxicity of extracts were evaluated respectively on human erythrocytes and according to OECD guideline N°423. 2, 2-diphenyl-1- picrylhydrazyl) radical scavenging, Ferric reducing antioxidant power, superoxyde radical scavenging and hydrogen peroxide radical scavenging methods were used to investigate antioxidant activity.
Results and conclusion: The best antiplasmodial activity was obtained with ethanolic extract of H. surattensis L. against field isolate (IC50 = 5.03±0.31 µg/mL) and Chloroquine -sensitive (IC50 = 7.55±0.59 µg/mL) whereas aqueous extract exhibited moderate activity. Bioassay-guided fractionation of ethanolic extract shows progressive decrease of the antiplasmodial activity. Both extracts exhibited strong antioxidant activity, hemolytic power less than 1%. No mortality of rats was recorded with ethanolic extract at 2000 mg/kg body weight. Flavonoids, anthraquinones, coumarins, and triterpenes are present in both extracts with tannins in the ethanolic extract. In summary, the extracts of H. surattensis have interesting antiplasmodial and antioxidant properties probably resulting from a synergetic action of their secondary metabolites, without toxicity effect on rats and human erythrocytes. These findings strengthen the traditional use of H. surattensis as antimalarial plants.
Keywords: Hibiscus surattensis; antiplasmodial; antioxidant; toxicity; phytoconstituents.
Isolation and Screening of Fungal Culture Isolated From Algerian Soil for the Production of Cellulase and Xylanase
Authors: GAHFIF Ouahiba , SOUAGUI Yasmina , AZZOUZ Zahra , NOUARI Sadrati , Zahir AMGHAR Zahir AMGHAR , BOUCHERBA Nawel , KECHA Mouloud , BENALLAOUA Said , Bettache Azzeddine 
Published: October 2020

Lignocellulolytic enzymes constitute a very large group of extracellular proteins secreting by fungi who is ecologically involved in the degradation of a variety of complex materials, a property that is attributed to a battery of enzymes produced by these microorganisms like cellulases and xylanases who are of significant industrial value and relevance. Forty fungal isolated from rich soil in organic matter were screened for lignocellulolytic enzymes production, its organized on the basis of their hydrolytic potential of cellulose and xylan. The isolates strains presented enzymatic activity which was ranked as follows: cellulolytic (56%), xylanolytic (44%). Some selected strains that produce high levels of enzymes (cellulase, xylanase) grown in submerged fermentation (SmF) and were quantitatively evaluated. The fermentation experiments were carried out in shake flasks. The highest CMCase (5,10 IU/ml) and xylanase (98,25 IU/ml) activities were obtained from Trichoderma sp strain Mtr6 isolate.
Keywords: Fungi, Trichoderma sp, lignocellulolytic enzymes, soil, screening, organic matter.
Formulation and Evaluation of Polymeric Nanoparticle by Nano-Precipitation Method
Authors: Umbarkar Mahesh G , Rindhe Pooja Sudhakar , Chandrawanshi Shivkanya Sanjay , Chavan Manoj J. , Manaskar Vijay 
Published: October 2020

Acyclovir is also known as Acyclovir, this drug is used for treatment of viral infection, particularly for treatment of herpes simplex viral infection. These are taken for month during treatment of herpes simplex viral infection. These are showing the action against all herps virus family. The acyclovir is poorly water-soluble drug. Due to that main aim is to increase the solubility of acyclovir in other solvent. The bioavailability of acyclovir is very less about (15-35%) because it has less oral route absorption. Due to that the acyclovir are given in intravenous route. When acyclovir is taken in oral route, the peak plasma concentration occurs after 1-2 h. The acyclovir having 9-33% of plasma protein binding. The BCS class of acyclovir are Class third (high solubility and Low permeability). Due to that acyclovir are formulate in the form of nanoparticle. Chitosan are the polymers which are used for the formulation of nanoparticle. The chitosan is found to be compatible with acyclovir. Formulation of acyclovir nanoparticle was done by Nano-precipitation method. Many evaluation tests performed during the formulation of Acyclovir nanoparticle mainly zeta sizer is use for the determination of particle size, zeta potential and PDI (poly disperse index) also performed evaluation of loading efficiency and % Drug entrapment.
Keywords: Acyclovir, Chitosan, Zeta sizer and Nanoparticle.
Evaluation of Anti-Anaphylactic Activity of methanolic extract of Momordica charantia in Experimental Animals
Authors: Deshpande Shubhangi Dhananjay , Kolhe Swati , Tembhurne Sachin 
Published: October 2020

Anaphylaxis is a syndrome that can be fatal, which is seen due to systemic release of inflammatory mediators. Antigen and Antibody reaction is usually a trigger in the body to go into anaphylactic shock. In this study, anaphylaxis induced by egg albumin in the rats. The efficiency of MC (Momordica charantia) against anaphylaxis was evaluated. The standard drug used was Dexamethasone. The MC extract is given in doses 100 and 200 mg/kg p.o.
Results: The MC extract was found to be effective (p<0.01) inhibitor of egg albumin induced anaphylactic reaction.
Conclusion: From this study, we can conclude that Momordica charantia fruits have good anti-anaphylactic activity.
Keywords: Anaphylaxis, Momordica charantia, Egg albumin, Passive paw anaphylaxis, Dexamethasone.
Sobre la materialidad del poema épico o cómo la edición no hace al libro: estética y canon en el sistema literario impreso
Authors: García-Minguillán Claudia 
Published: October 2020

La renovación del sistema literario surgida a la estela de los movimientos culturales del siglo xviii alteró la estática situación en la que se encontraba el género épico. Al calor del enfrentamiento entre antiguos y modernos, se publican y acompañan nuevas traducciones y ediciones de los clásicos grecolatinos, lo que incita la composición de nuevos poemas épicos y los posteriores debates entorno a la forja de un canon. En este trabajo proponemos un estudio que aborda la construcción y la estética de este grupo de textos en cuanto a su soporte material: edición, ilustraciones, grabados, colecciones, obras completas. Se alcanza a observar cómo la concepción física de un libro fomenta la institucionalización o no de un canon literario, junto a una estética reconocible y asimilable por el público.
A new sperm selection criterion for cryopreservation of boar semen
Authors: Trzcińska Monika , Bryła Magdalena 
Published: October 2020

Abstract
This study aimed to define potential markers that could determine the suitability of ejaculate for cryopreservation. Fresh semen from eleven boars (4–7 ejaculates/boar), regardless of their sperm motility, was subjected to a cryopreservation procedure. The sperm quality before and after freezing was assessed based on the sperm membrane permeability and acrosome integrity. The results showed that it was possible to effectively cryopreserve ejaculates below the accepted standards of 70–80% of fresh motile sperm and still obtain a high cryosurvival rate. Moreover, a significant correlation was found between the percentage of viable sperm with apoptotic-like changes, viable sperm with reacted acrosomes, and the cryosurvival rate. The proposed markers for assessing the quality of fresh semen could be used to predict the success of cryopreservation procedures.
Explore the Lessee Accounting Treatment When Utilizing the Islamic Financial Leasing
Authors: Morshed Amer , Széles Zsuzsanna 
Published: October 2020

Abstract
This study aims to discuss the effects of the AAIOFI accounting standards of financial leased assets on the accounting treatment of the lessee in the case of using the Islamic finance lease. The importance of this study became evident when AAIOFI announced Islamic accounting standards with a significant difference between the IFRSs about the recognition of leased financial assets. Islamic financial institutions recognize the financial leased assets following AAIOFI accounting under long-term assets in the statement of financial position. This study used the interviews as a qualitative research method with financial managers of Jordanian companies using Islamic financial leasing. This study reached the conclusion that both Islamic financial leasing parties recognize the assets in the long-term asset side. The recommendations to avoid the inflation of the Islamic financial leased assets will be by applying a reasonable accountancy treatment by the lessee and consider it as operational leasing with proper justification for the non-compliance with the IFRS.
3D Design of Clothing in Medical Applications
Authors: Cichocka Agnieszka , Frydrych Iwona , Zimniewska Małgorzata , Muzyczek Małgorzata , Mikołajczak Przemysław , Schmidt-Przewoźna Katarzyna , Romanowska Barbara , Pawlaczyk Mariola , Krucińska Izabella , Komisarczyk Agnieszka , Kowalska Stanisława , Herczyńska Lucyna , Urbaniak Monika 
Published: October 2020

Abstract
In this paper, we present a new methodology of clothing engineering construction for the medical application. Project “BIOAKOD” intends to propose clothing solutions for elderly people with dermatological defects. This purpose requires a particular concept of clothing because of the additional functionality expected in the clothing. It means that the proposed clothing needs to cover a human body in an aesthetic way and gives comfort of use it, and it should also bring an adding value in health treatment of people with dermatosis (psoriasis)..
Determination of Sewing Thread Consumption for 602, 605, and 607 Cover Stitches Using Geometrical and Multi-Linear Regression Models
Authors: Sarah Malek , Boubaker Jaouachi , Dominique Adolphe Charles 
Published: October 2020

Abstract
This work deals with prediction of the quantities of sewing threads required to sew a garment using cover stitches for the different classes of 600 (602, 605 and 607 cover stitches) by performing a rapid and precise methods (Geometrical and statistical). Sewing consumption value was estimated based on the geometrical method of different cover stitch shapes to prevent inventory of stocks for each stitch type. In the prediction of the sewing thread consumption for each investigated stitch, it was assumed that the consumption is a function of the input parameters, such as material thickness, stitch density, yarn linear density, and seam width. In addition, a statistical method based on multi-linear regression was established. The coefficient R2 value was determined to evaluate the precision of the geometrical and statistical methods. By comparing the theoretical thread consumption with the experimental ones, it is concluded that the geometrical method is more accurate than the statistical method regarding the range of R2 (from 98.78% to 99.38%), which encouraged industrialists to use geometrical models to predict thread consumption.
The input parameters contributing to the sewing thread consumption behavior were studied and analyzed. It was concluded that the most important parameters influencing thread consumption are stitch density followed by seam width. Both yarn density and material thickness have a low contribution to the thread consumption value.
Computer-Assisted Modeling and Design of Compression Garments with Graded Unit Compression
Authors: Kowalski Krzysztof , Kłonowska Magdalena , Sujka Witold , Latańska Ilona , Kowalski Tomasz Marek 
Published: October 2020

Abstract
This article presents a useful algorithm for designing compression products with intended and graded unit pressure along the part of the body covered with the mentioned garments. The algorithm was developed using Laplace's law and a designated experimental function describing the relationship between strength and relative elongation of knitted fabric, and the results of 3D scanning of different body parts. On this basis, two examples of products in the form of a leg sleeve and arm sleeve were designed for the treatment of lymphoedema in compression classes II and III. The presented compression product design procedure facilitates the process of designing compression garments and eliminates some errors related to this procedure.
Impact of crop stand, Rhizobium inoculation, and foliar fertilization on pea root parameters
Authors: Klimek-Kopyra Agnieszka , Neugschwandtner Reinhard W. , Gląb Tomasz , Oleksy Andrzej , Zając Tadeusz 
Published: October 2020

Summary
Ecological intensification of crop production involves the use of intercrops and the rational use of inoculation and fertilization in case of intercrops including legume species. The root system plays an important role in the productivity of crops. Therefore, effects of the inoculation treatments (Nitragina) or foliar fertilization (Photrel) or a combination of both were assessed on root parameters of pea grown as pure stand or intercrops with linseed or wheat in a 3-year experiment in Poland. Crop stand composition influenced the root parameters of pea with a higher root length density (RLD) in the root fractions of 0.1–1 mm of pea in pea/linseed intercrops than in the pure stand, a higher mean root diameter (MRD) in pure pea and intercrops of pea with linseed than with wheat, and also a tendency of a higher root dry matter (RDM) in pure pea and pea/linseed than in pea/wheat in 2 out of the 3 years. RLD was higher with Photrel than with Nitragina in root fractions of 0.1–0.5 mm. Treatments did not affect the MRD, but a combination of Nitragina + Photrel increased the RDM in 1 year. Intercropping of pea with linseed and the application of a foliar fertilizer might be a strategy to improve pea root characteristics.
Effect of the Glycemic Index of Meals on Physical Exercise: A Case Report
Authors: Biagini Andrea , Albi Elisabetta 
Published: October 2020

Abstract
Carbohydrate uptake before physical exercise allows to maintain plasma glucose concentration. Though, foods or beverages containing the same carbohydrate concentration do not produce the same glycemic and insulin responses which are related to their glycemic index (GI). Last, most studies of CHO loading have been conducted with male subjects, with the assumption that the results also apply to female athletes.
Sixteen volunteer amateur athletes, eight men and eight women (age 39.1 ± 7.8 y; VO2max 55,7 ± 11,7 ml/kg/min), were selected and then divided into four groups of four people each one. The trial was divided into several days, one for each group. A carbohydrate source or a placebo (energy 86,5 ± 6,7 kcal; CHO 20,0 g; fat 0,3 ± 0,3 g; protein 0,8 ± 0,8 g) was assigned randomly to each athlete in the group: these supplements differed in the ability to increase blood glucose (banana: high-GI; dried apricots: low-GI; energy gel: mixture of CHO with different blood release), while the placebo was composed of water, sodium cyclamate, sodium saccharin and acesulfame potassium. Three blood samples were taken from each athlete from finger, by glucometer: one before supplementation, one half an hour later – at the start of the run – and one at the end of the exercise.
Physical activity consisted of 40 minutes run at medium-high intensity, corresponding to 82% of maximum heart rate or 70% of VO2max. In order to improve the analysis of the results obtained from the detection of biological samples, a questionnaire was submitted to all participants to know their lifestyle and anthropometric and physiological data.
Results highlighted a different glycemic response between men and women, suggesting the consumption of low-GI food rather than high-GI before physical exercise in order to keep plasma glucose levels constant.
Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction
Authors: Denmark Daniel J. , Mohapatra Subhra , Mohapatra Shyam S. 
Published: October 2020

Abstract
Significant healthcare disparities resulting from personal wealth, circumstances of birth, education level, and more are internationally prevalent. As such, advances in biomedical science overwhelmingly benefit a minority of the global population. Point-of-Care Testing (POCT) can contribute to societal equilibrium by making medical diagnostics affordable, convenient, and fast. Unfortunately, conventional POCT appears stagnant in terms of achieving significant advances. This is attributed to the high cost and instability associated with conventional biorecognition: primarily antibodies, but nucleic acids, cells, enzymes, and aptamers have also been used. Instead, state-of-the-art biosensor researchers are increasingly leveraging molecularly imprinted polymers (MIPs) for their high selectivity, excellent stability, and amenability to a variety of physical and chemical manipulations. Besides the elimination of conventional bioreceptors, the incorporation of nanomaterials has further improved the sensitivity of biosensors. Herein, modern nanobiosensors employing MIPs for selectivity and nanomaterials for improved transduction are systematically reviewed. First, a brief synopsis of fabrication and wide-spread challenges with selectivity demonstration are presented. Afterward, the discussion turns to an analysis of relevant case studies published in the last five years. The analysis is given through two lenses: MIP-based biosensors employing specific nanomaterials and those adopting particular transduction strategies. Finally, conclusions are presented along with a look to the future through recommendations for advancing the field. It is hoped that this work will accelerate successful efforts in the field, orient new researchers, and contribute to equitable health care for all.