bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a High-performance Liquid Chromatography Method for Simultaneous Determination of Loratadine and its Metabolite Desloratadine in Human Plasma
Authors: Sebaiy Mahmoud M. , Ziedan Noha I. 
Published: November 2019

Background:
Allergic diseases are considered as the major burden on public health with increased prevalence
globally. Histamine H1-receptor antagonists are the foremost commonly used drugs in the treatment of allergic
disorders. The target drug in this study, loratadine, belongs to this class of drugs and its biometabolite desloratadine
which is also a non-sedating H1 receptor antagonist with anti-histaminic activity being 2.5 to 4 times greater than
loratadine. This study aimed to develop and validate a novel isocratic Reversed-phase High-Performance Liquid
Chromatography (RP-HPLC) method for rapid and simultaneous separation and determination of loratadine and its
metabolite, desloratadine in human plasma.

Methods:
The drug extraction method from plasma was based on protein precipitation technique. The separation was
carried out on a Thermo Scientific BDS Hypersil C18 column (5μm, 250 x 4.60 mm) in a mobile phase of MeOH:
0.025M KH2PO4 adjusted to pH 3.50 using orthophosphoric acid (85: 15, v/v) at an ambient temperature. The flow
rate was maintained at 1 mL/min and maximum absorption was measured using the PDA detector at 248 nm.

Results:
The retention times of loratadine and desloratadine in plasma samples were recorded to be 4.10 and 5.08
minutes, respectively, indicating a short analysis time. Limits of detection were found to be 1.80 and 1.97 ng/mL for
loratadine and desloratadine, respectively, showing a high degree of sensitivity of the method. The method was then
validated according to FDA guidelines for the determination of the two analytes in human plasma.

Conclusion:
The results obtained indicate that the proposed method is rapid, sensitive in the nanogram range, accurate,
selective, robust and reproducible compared to other reported methods.
A Chatbot Versus Physicians to Provide Information for Patients With Breast Cancer: Blind, Randomized Controlled Noninferiority Trial
Authors: Bibault Jean-Emmanuel , Chaix Benjamin , Guillemassé Arthur , Cousin Sophie , Escande Alexandre , Perrin Morgane , Pienkowski Arthur , Delamon Guillaume , Nectoux Pierre , Brouard Benoît 
Published: November 2019

Background
The data regarding the use of conversational agents in oncology are scarce.

Objective
The aim of this study was to verify whether an artificial conversational agent was able to provide answers to patients with breast cancer with a level of satisfaction similar to the answers given by a group of physicians.

Methods
This study is a blind, noninferiority randomized controlled trial that compared the information given by the chatbot, Vik, with that given by a multidisciplinary group of physicians to patients with breast cancer. Patients were women with breast cancer in treatment or in remission. The European Organisation for Research and Treatment of Cancer Quality of Life Group information questionnaire (EORTC QLQ-INFO25) was adapted and used to compare the quality of the information provided to patients by the physician or the chatbot. The primary outcome was to show that the answers given by the Vik chatbot to common questions asked by patients with breast cancer about their therapy management are at least as satisfying as answers given by a multidisciplinary medical committee by comparing the success rate in each group (defined by a score above 3). The secondary objective was to compare the average scores obtained by the chatbot and physicians for each INFO25 item.

Results
A total of 142 patients were included and randomized into two groups of 71. They were all female with a mean age of 42 years (SD 19). The success rates (as defined by a score >3) was 69% (49/71) in the chatbot group versus 64% (46/71) in the physicians group. The binomial test showed the noninferiority (P<.001) of the chatbot’s answers.

Conclusions
This is the first study that assessed an artificial conversational agent used to inform patients with cancer. The EORTC INFO25 scores from the chatbot were found to be noninferior to the scores of the physicians. Artificial conversational agents may save patients with minor health concerns from a visit to the doctor. This could allow clinicians to spend more time to treat patients who need a consultation the most.

Trial Registration
Clinicaltrials.gov NCT03556813, https://tinyurl.com/rgtlehq
A Web-Based Program for Cannabis Use and Psychotic Experiences in Young People (Keep It Real): Protocol for a Randomized Controlled Trial
Authors: Hides Leanne , Baker Amanda , Norberg Melissa , Copeland Jan , Quinn Catherine , Walter Zoe , Leung Janni , Stoyanov Stoyan R , Kavanagh David 
Published: November 2019

Background
Young Australians (16-25 years) have the highest rates of past-month cannabis use in the world. Cannabis use increases the risk of alcohol and other drug disorders and depressive disorders, and has a robust dose-response association with psychotic experiences (PEs) and disorders. PEs are subthreshold positive psychotic symptoms, including delusions and hallucinations, which increase the risk of substance use, depressive or anxiety disorders, and psychotic disorders. Access to effective web-based early interventions targeting both cannabis use and PEs could reduce such risk in young people.

Objective
The objective of this study is to determine the efficacy and cost-effectiveness of the Keep it Real web-based program compared to an information-only control website among young cannabis users (16-25 years) with PEs.

Methods
Participants are recruited online, and consenting individuals meeting inclusion criteria (aged 16-25 years, who have used cannabis in the past month and experienced PEs in the past 3 months) are automatically randomized to either the Keep it Real web-based program (n=249) or an information-only control website (n=249). Both websites are self-guided (fully automated). The baseline and follow-up assessments at 3, 6, 9, and 12 months are self-completed online. Primary outcome measures are weekly cannabis use, PEs, and the relative cost-effectiveness for quality-adjusted life years. Secondary outcomes include other substance use and related problems, PE-related distress, cannabis intoxication experiences, severity of cannabis dependence, depression/anxiety symptoms, suicidality, and mental well-being and functioning.

Results
Recruitment commenced in February 2019, and the results are expected to be submitted for publication in mid-2021.

Conclusions
This study protocol describes a large randomized controlled trial of a new web-based program for young cannabis users experiencing PEs. If effective, the accessibility and scalability of Keep it Real could help reduce growing public health concerns about the significant social, economic, and health impacts of cannabis use.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12618001107213; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374800

International Registered Report Identifier (IRRID)
DERR1-10.2196/15803
The “Preparation for Shared Decision-Making” Tool for Women With Advanced Breast Cancer: Qualitative Validation Study
Authors: Masi Domitilla , Gomez-Rexrode Amalia Elvira , Bardin Rina , Seidman Joshua 
Published: November 2019

Background
The range of decisions and considerations that women with advanced breast cancer (ABC) face can be overwhelming and difficult to manage. Research shows that most patients prefer a shared decision-making (SDM) approach as it provides them with the opportunity to be actively involved in their treatment decisions. The current engagement of these patients in their clinical decisions is suboptimal. Moreover, implementing SDM into routine clinical care can be challenging as patients may not always feel adequately prepared or may not expect to be involved in the decision-making process.

Objective
Avalere Health developed the Preparation for Shared Decision-Making (PFSDM) tool to help patients with ABC feel prepared to communicate with their clinicians and engage in decision making aligned with their preferences. The goal of this study was to validate the tool for its acceptability and usability among this patient population.

Methods
We interviewed a diverse group of women with ABC (N=30). Interviews were audiorecorded, transcribed, and double coded by using NVivo. We assessed 8 themes to understand the acceptability and usability of the tool.

Results
Interviewees expressed that the tool was acceptable for preparing patients for decision making and would be useful for helping patients know what to expect in their care journey. Interviewees also provided useful comments to improve the tool.

Conclusions
This validation study confirms the acceptability and usability of the PFSDM tool for women with ABC. Future research should assess the feasibility of the tool’s implementation in the clinical workflow and its impact on patient outcomes.
State variables monitoring using a class of nonlinear observer based estimator, applied to continuous bio-system
Authors: Aguilar-López Ricardo , Acevedo-Gómez Ricardo , Neria González Marí­a Isabel , Domí­nguez-Bocanegra Alma Rosa 
Published: November 2019

In this work, the state estimation of key variables such as biomass and products of a sulfate reducing bacterium is predicted by using only sulfate (substrate) concentration measurements under the assumption of an unknown kinetic term. The process was developed by ontinuous culture, where the mathematical kinetic model for the biomass, sulfate and sulfide concentrations is presented and tuned using experimental data. The design of the nonlinear state estimator takes into account an adaptive gain. The results of the proposed estimation methodology were generated via numerical simulation; they showed a satisfactory performance.
Optimal Workflow Scheduling in Critical Infrastructure Systems with Neural Networks
Authors: Vukmirović S. , Erdeljan A. , Imre L. , Čapko D. 
Published: November 2019

Critical infrastructure systems (CISs), such as power grids, transportation systems, communication networks and water systems are the backbone of a country’s national security and industrial prosperity. These CISs execute large numbers of workflows with very high resource requirements that can span through different systems and last for a long time. The proper functioning and synchronization of these workflows is essential since humanity’s well-being is connected to it. Because of this, the challenge of ensuring availability and reliability of these services in the face of a broad range of operating conditions is very complicated. This paper proposes an architecture which dynamically executes a scheduling algorithm using feedback about the current status of CIS nodes. Different artificial neural networks (ANNs) were created in order to solve the scheduling problem. Their performances were compared and as the main result of this paper, an optimal ANN architecture for workflow scheduling in CISs is proposed. A case study is shown for a meter data management system with measurements from a power distribution management system in Serbia. Performance tests show that significant improvement of the overall execution time can be achieved by ANNs.
Applying Non-Steady-State Photo-Emf Technique to Detection of Higher Order Auto Correlation Functions of Ultrashort Optical Pulses
Authors: Moreno Zarate P. , S. Shcherbakov Alexandre , Mansurova Svetlana 
Published: November 2019

Here we examine a new application of the adaptive detectors based on non-steady-state photo-electro-motive force effect for the detection of higher order correlation functions, aiming the estimation of the parameters of ultra short optical pulses arranged in high-repetition trains. For this purpose three beam interferometer scheme with two signal beams modulated at different frequencies is proposed. Theoretical analysis of non-steady-state photo-EMF current generated by light distribution formed by superposition of three waves is performed and the possibility to detect simultaneously second and higher order correlation function is demonstrated. Potential advantages and disadvantages of such detection scheme for measuring the higher order auto-correlations functions are discussed.
Design of a Qubit and a Decoder in Quantum Computing Based on a Spin Field Effect
Authors: A. Suratgar A. , Rafiei S. , A. Taherpour A. , Babaei A. 
Published: November 2019

In this paper we present a new method for designing a qubit and decoder in quantum computing based on the field effect in nuclear spin. In this method, the position of hydrogen has been studied in different external fields. The more we have different external field effects and electromagnetic radiation, the more we have different distribution ratios. Consequently, the quality of different distribution ratios has been applied to the suggested qubit and decoder model. We use the nuclear property of hydrogen in order to find a logical truth value. Computational results demonstrate the accuracy and efficiency that can be obtained with the use of these models.
PARENIALISME SEBAGAI LANDASAN DALAM PEMBELAJARAN BAHASA INDONESIA
Authors: Riyanti Asih 
Published: November 2019

Parenialisme lahir sebagai reaksi dan solusi terhadap pembelajaran progresif karena adanya keadaan krisis kebudayaan dalam kehidupan yang modern. Filsafat progresivisme menekankan perubahan menuju hal baru, sedangkan filsafat parenialisme mengedepankan jalan mundur ke masa lampau, yakni mengembalikan nilai dan prinsip yang telah menjadi pandangan hidup yang kukuh pada zaman dahulu. Pengembalian atas nilai dan prinsip hidup tersebut dapat ditempuh melalui pendidikan, yakni dalam pembelajaran bahasa Indonesia. Setiap manusia memiliki bahasa sebagai alat komunikasi antarsesama. Melalui bahasa, maka seseorang dapat menyampaikan ide, gagasan, atau mengetahui informasi yang dibutuhkan. Pembelajaran bahasa Indonesia diajarkan pada semua jenjang pendidikan baik sekolah dasar hingga perguruan tinggi. Pembelajaran bahasa Indonesia dianggap wajib dan penting di dunia pendidikan karena sebagai bahasa persatuan, bahasa kebangsaan, dan sebagai jati diri bangsa Indonesia. Dalam proses pembalajaran, bahasa Indonesia bukan hanya pencapaian pengetahuan terkait bahasa untuk tujuan akademik, tetapi tetap tidak mengesampingkan nilai dan prinsip hidup dalam konsep pendidikan yang secara integral dalam payung dari disiplin ilmu pendidikan, yakni salah satunya filsafat parenialisme. Pada pembelajaran bahasa Indonesia, parenialisme sebagai landasan dalam teori, praktik, proses pelaksaan pembelajaran sampai pada tahap evaluasi pembelajaran. Belajar bahasa Indonesia berarti pula memenuhi fungsi praktik filosofi baik ilmu, etika berbahasa, sosial, politik serta seni relevansinya terhadap budaya.Kata Kunci: Parenialisme; Pembelajaran Bahasa Indonesia
PERANG TIPAT BANTAL DESA ADAT KAPAL (ACI RAH PENGANGGON)
Authors: Supriadi Mardiki , Zakiah Linda 
Published: November 2019

Keberadaan Tradisi Aci Rah Pengangon atau yang lebih dikenal dengan tradisi Perang Tipat-Bantal dipercayai membawa pengaruh yang besar terhadap kelangsungan hidup masyarakat Desa Kapal yang masih berlangsung hingga sekarang ini. Banyak dijelaskan dalam catatan-catatan sejarah kuno berupa lontar-lontar, salah satunya menceritakan asal mula pelaksanaan tradisi ini terdapat dalam Lontar Tabuh rah Pengangon. Dalam lontar tersebut dikisahkan di zaman dahulu, yaitu tepatnya di tahun Isaka 1259 atau tahun 1337 Masehi. Tradisi perang tipat bantal erat kaitannya dengan kehidupan pertanian masyarakat. Ini merupakan sebuah tradisi unik yang dilaksanakan sebagai rasa syukur kehadapan Tuhan Yang Maha Esa atas kehidupan yang diciptakanNya, serta berlimpahnya hasil panen yang ada di Desa Kapal. Selain sebagai ritual, tradisi perang tipat bantal di desa adat kapal juga berfungsi sebagai sarana pendidikan bagi masyarakat desa adat kapal. Pelaksanaan tradisi perang tipat bantal merupakan sebuah tradisi kuno yang mendirikan kearifan lokal masyarakat desa adat kapal yang mempunyai tujuan untuk menyeimbangkan dan menjaga keharmonisan hubungan manusia dengan alam. Selain mempunyai maksud dan tujuan, banyak terkandung nilai-nilai pendidikan yang dapat kita pelajari di dalam melaksanakan tradisi perang tipat bantal.Kata Kunci: Kearifan Lokal; Nilai-Nilai Pendidikan; Tradisi Perang Tipat-Bantal
THE ROLE OF SOCIAL COMMERCE CONSTRUCTS, SOCIAL SUPPORT, AND TRUST IN COMMUNITY ON SOCIAL COMMERCE ACTIVITIES
Authors: Hidayatulloh Amir 
Published: November 2019

This study aims to analyze social commerce constructs, social support, and individual trust in the community in social commerce activities. Social support includes emotional support and informational support. The population was social media users, while the samples were social media users who had made purchase at least two transactions through social media. The sampling technique was convenience sampling. Totally, 162 respondents were involved. Hypothesis testing was done using Warp PLS. This study reveals that individual trust in the community can be built directly through the social commerce constructs. These constructs affects both emotional support and information support, in which they will ultimately affect the individual trust in the community. Furthermore, social commerce intention is influenced by individual trust in the community and emotional support. However, information support does not affect the social commerce intention.
FACTORS AFFECTING MSME’s INTEREST TO APPLY FOR BUSINESS FINANCING IN ISLAMIC FINANCIAL INSTITUTIONS
Authors: Rohmah Mayda Miftakhur , Rintasari Nugraheni 
Published: November 2019

This study aims to determine the effect of services, procedure, reputation, and promotion on the MSMEs’ interest to apply for business financing provided by Islamic financial institutions. It is a quantitative research. The data were primary data obtained from questionnaires that were distributed directly to the respondents. As many as 58 MSME actors in the Manding Leather Craft Center, Bantul, Indonesia, were involved as the respondents. The sampling technique was purposive sampling as a type of the non probability sampling method. Data analysis methods included multiple linear regression, classical assumption test, and hypothesis testing (t-test and F-test). Data processing required the assistance of SPSS 17.0. The results of the t-test show that each independent variable partially affects the MSMEs’ interest to apply for Islamic financing. Furthermore, the results of the F-test indicate that the variables of services, procedure, reputation, and promotion simultaneously affect the MSMEs’interest to apply for business financing provided by Islamic financial institutions.
Motivasi Belajar Siswa yang Berlatar Belakang Budaya Melayu dan Jawa
Authors: 1 Hasgimianti , Putri Ramtia Darma , MRA Raja Rahima 
Published: November 2019

Education is a process that students can use to develop their own potential.This was a descriptive comparative research which applied quantitative method. The essence of education is learning. There is no education without learning activities. Student learning motivation is influenced by the cultural background. By Slovin formula followed by simple random sampling technique, 200 students were choosen as the sample at SMP Negeri 1 Siak Hulu Kabupaten Kampar in Academic Year 2015/2016. The data gathered were analyzed by using descriptive statistic and MANOVA (multivariate analysis of variance). The result of the research indicated that: The students' learning motivation with Malaynese cultural backgrounds are in the high category; The students' learning motivation with Javanese cultural backgrounds are are in very high category; and There is no significance different attention of parents between with Malaynese and Javanese cultural backgrounds, while there are siginificant differences in learning motivation. Learning motivation among students who Malaynese cultural backgrounds and Javanese cultural backgrounds. between the students' cultural backgrounds Malaynese and Javanese
PERBEDAAN PENYESUAIAN SOSIAL MAHASISWA DILIHAT DARI POLA ASUH ORANG TUA
Authors: Wati Lidya , Hasgimianti Hasgimianti 
Published: November 2019

Penelitian ini bertujuan untuk mengetahui bagaimana pola asuh orang tua. Perkembangan sikap anak tergantung dari bagaimana cara didikan orang tua terhadap anak. Oleh sebab itu pola asuh orang tua sangatlah penting bagi anak, selain itu pun pola asuh orang tua juga merupakan salah satu factor bagaimana anak bersikap atau bertingkah laku di lingkungan sekitarnya. Dalam penenlitian ini menggunakan desain korelatif yang dilihat di lingkungan UIN SUSKA. Hasil penelitian ini di dapatkan dari melalui penyebaran angket, yang disebarkan ke 30 mahasiswa di UIN SUSKA. Hasil penelitian menyebutkan bahwa penyesuaan diri yang negative berupa berpacaran sebanyak 21 mahasiswa (70). Hal itu berada pada Klasifikasi Tinggi. Sedangkan Klasifikasi Sedang sebanyak 9 mahasiswa (30).
Analisis Kemampuan Literasi Matematika ditinjau dari Gaya Belajar Siswa SMA
Authors: Edimuslim E. , Edriati Sofia , Mardiyah Ainil 
Published: November 2019

ABSTRAK. Penelitian ini bertujuan untuk mendeskripsikan kemampuan literasi matematika siswa berdasarkan kemampuan Reproduksi, Koneksi dan Refleksi ditinjau dari gaya belajar siswa kelas XII MIA 3. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan memperoleh kualitatif. Instrumen yang digunakan adalah angket gaya belajar dan tes kemampuan literasi matematika serta bimbingan wawancara. Teknik analisis data yang digunakan adalah analisis tes gaya belajar dan analisis tes kemampuan literasi matematika dengan uji keabsahan data menggunakan triangulasi metode. Hasil penelitian ini menunjukkan fakta; 1) Gaya belajar siswa yang dominan adalah Visual, Auditorial dan Kinestetik; 2) Siswa pada gaya belajar Visual dengan kompetensi.Siswa dengan kompetensi mampu memecahkan masalah tetapi kesulitan dalam proses memilih strategi untuk memecahkan masalah. Siswa dengan kompetensi Refleksi mampu memenuhi semua indikator pada soal level 5; 3) Siswa pada gaya belajar Auditorial dengan kompetensi Reproduksi belum memenuhi proses menggunakan bahasa dan operasi simbolis. Siswa dengan kompetensi mampu memenuhi indikator Komunikasi, matematisasi serta mampu menggunakan strategi untuk mengatasi masalah; 4) Siswa dengan gaya belajar Kinestetik dengan kompetensi Reproduksi belum memenuhi indikator proses komunikasi, matematisasi serta memilih strategi untuk memecahkan masalah.Siswa dengan kompetensi koneksi dapat memilih indikator proses menggunakan alat matematika, representasi, matematisasi serta memilih strategi pemecahan masalah. Kata Kunci : Gaya Belajar, Kemampuan Literasi Matematika.
Un relato en el hielo: de la postergación editorial como estrategia literaria en un relato de Ricardo Piglia
Authors: Olivati Mirko 
Published: November 2019

El objetivo de este artículo es ofrecer un análisis del cuento “Un pez en el hielo” de Ricardo Piglia, publicado en la nueva edición de 2006 de la colección de cuentos La invasión, primer libro del escritor argentino en 1967. En las próximas páginas se considerarán las elecciones editoriales de Piglia, los textos teóricos sobre el cuento que el autor publicó entre la primera y la segunda edición de La invasión, las indicaciones que dejó en su obra autoficcional Los diarios de Emilio Renzi y la relación artística que Piglia quiso instaurar con el escritor italiano Cesare Pavese escribiendo este cuento, para mostrar cómo un relato aparentemente lineal puede adquirir un espesor y una profundidad particulares gracias a las estrategias literarias del escritor, evidenciando posibilidades aún no exploradas para el género literario del relato.