bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis
Authors: Zhu Wei-min , Yuan Zhe , Zhou Hong-yu 
Published: January 2020

Abstract
Background
Studies on risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection have provided inconsistent results, partly due to the choice of the control group. We conducted a systematic review and meta-analysis to assess the risk factors for CRKP infection by comparing CRKP-infected patients with two types of controls: patients infected with carbapenem-susceptible Klebsiella pneumoniae (comparison 1) or patients not infected with CRKP (comparison 2).

Methods
Data on potentially relevant risk factors for CRKP infection were extracted from studies indexed in PubMed, EMBASE, Web of Science or EBSCO databases from January 1996 to April 2019, and meta-analyzed based on the outcomes for each type of comparison.

Results
The meta-analysis included 18 studies for comparison 1 and 14 studies for comparison 2. The following eight risk factors were common to both comparisons: admission to intensive care unit (ICU; odds ratio, ORcomparison 1 = 3.20, ORcomparison 2 = 4.44), central venous catheter use (2.62, 3.85), mechanical ventilation (2.70, 4.78), tracheostomy (2.11, 8.48), urinary catheter use (1.99, 0.27), prior use of antibiotic (6.07, 1.61), exposure to carbapenems (4.16, 3.84) and exposure to aminoglycosides (1.85, 1.80). Another 10 risk factors were unique to comparison 1: longer length of hospital stay (OR = 15.28); prior hospitalization (within the previous 6 months) (OR = 1.91); renal dysfunction (OR = 2.17); neurological disorders (OR = 1.52); nasogastric tube use (OR = 2.62); dialysis (OR = 3.56); and exposure to quinolones (OR = 2.11), fluoroquinolones (OR = 2.03), glycopeptides (OR = 3.70) and vancomycin (OR = 2.82).

Conclusions
Eighteen factors may increase the risk of carbapenem resistance in K. pneumoniae infection; eight factors may be associated with both K. pneumoniae infections in general and CRKP in particular. The eight shared factors are likely to be ‘true’ risk factors for CRKP infection. Evaluation of risk factors in different situations may be helpful for empirical treatment and prevention of CRKP infections.
Psychosocial impact of prognostic genetic testing in uveal melanoma patients: a controlled prospective clinical observational study
Authors: Lieb Marietta , Tagay Sefik , Breidenstein Anja , Hepp Tobias , Le Guin Claudia H. D. , Scheel Jennifer , Lohmann Dietmar R. , Bornfeld Norbert , Teufel Martin , Erim Yesim 
Published: January 2020

AbstractBackgroundThe risk of metastases in uveal melanoma can accurately be estimated through genetic analysis of the tumor. A growing number of patients decide to receive information on their prognosis, although this can be extremely burdensome. Studies on the psychosocial impact of testing are sparse. The objective of this study was to examine traits of patients opting for prognostication, to investigate its psychosocial impact and the use of psycho-oncological services over time. We further examined characteristics of patients utilizing these services and risk factors of prolonged psychological distress.Design and methodsThis study is a non-randomized controlled prospective clinical observational trial. Patients availing for prognostication formed the test group, while those who opted out constituted the observational group. The psychosocial impact of genetic testing was assessed with the following variables: resilience, social support, fear of tumor progression, depression, general distress, health-related quality of life, estimation of the perceived risk, and the utilization of psycho-oncological interventions. Data were assessed at five different time points over a period of 12 months. We applied binary logistic regression analysis, multiple linear regressions and a mixed model.ResultsOf 175 patients, 63 decided to obtain prognostic information. Treatment method (enucleation > brachytherapy), lower social support and higher general distress could significantly predict patient’s choice for prognostic testing. After result announcement, perceived risk of metastases was significantly increased in patients with poor prognosis, while it decreased in those with good prognosis. Overall, a significant decrease over time appeared concerning fear of progression, general distress, depression and anxiety. Mental quality of life increased over time. The utilization of psycho-oncological interventions increased significantly after prognostication; however, this was equivalent in the test and observational groups. Female sex, higher general distress and higher anxiety predicted greater use of psycho-oncological interventions.DiscussionAvailing of prognostic testing is not associated with poorer subsequent psychological well-being. It rather may help to alleviate distress and promote a more realistic risk perception. However, psychological support should be available to all patients, independent of prognosis and treatment, especially considering that patients with low social support and high distress increasingly opt for prognostication.
The clinical effects of school sandplay group therapy on general children with a focus on Korea Child & Youth Personality Test
Authors: Kwak Hyeon Jeong , Ahn Un Kyoung , Lim Myung Ho 
Published: January 2020

Abstract
Background
This study intended to examine the comprehensive clinical effects of school sandplay group counseling on the emotions and behaviors of children for the first time in Korea.

Methods
To this objective, 10 sessions of in-school sandplay group counseling were administered to 113 fourth- to sixth-graders in an elementary school located in Cheonan city for 12 weeks from March to July 2015. Each small group consisted of 10 to 16 children and the entire 12 sessions were composed of a baseline test, 10 therapy sessions, and a post-test and evaluation session. The study subjects consisted of 56 boys (49.6%) and 57 girls (50.4%). As the evaluation instruments, an epidemiologic questionnaire and the Korea Child & Youth Personality Test were used during the baseline phase and after the termination of the counseling.

Results
The comparison of the scores according to the KCYP clinical scales and detailed evaluation scales before and after the 12-week counseling showed an increase in the self-esteem and a significant decline in depression in the elementary students after the counseling.

Conclusion
It is deemed that school sandplay group counseling can help elementary school students to solve emotional problems and improve their self-esteem.
Reviving WHAAM! a comparative evaluation of cleaning systems for the conservation treatment of Roy Lichtenstein’s iconic painting
Authors: Bartoletti Angelica , Barker Rachel , Chelazzi David , Bonelli Nicole , Baglioni Piero , Lee Judith , Angelova Lora V. , Ormsby Bronwyn 
Published: January 2020

Abstract
Roy Lichtenstein’s Whaam! (1963) is an iconic artwork in Tate’s collection (T00897). Over the past 50 years, the painting has been on almost continuous display and had accrued a layer of deposited soiling, which resulted in the dampening of Lichtenstein’s vibrant colours and the masking of numerous subtleties across the painting surface. This paper outlines the design and execution of an optimal soiling removal strategy for this challenging work; utilising collaborative, practice-based research. The conservation treatment employed was derived through an iterative process that reflected and supported the conservation decision-making process. The research strands included: technical and art historical investigations to determine the materials and construction of Whaam! and to define the aims of the conservation treatment; preparation of accelerated aged and artificially soiled test (mock-up) paint samples based on contemporary equivalent materials and a comparative evaluation of a range of established and novel soil-removal systems, followed by further tailoring for use on the work of art. The range of cleaning systems evaluated included free-solvents, gels and emulsifiers; which were documented using star diagrams, digital microscopy and infrared spectroscopy. After a rigorous process of assessment and refinement, the strategy taken forward to Whaam! included the use of a polyvinyl alcohol-based polymeric hydrogel (Nanorestore Gel® Peggy 6), uploaded with tailored aqueous solutions. This process facilitated a low risk, controlled and even-removal of the soiling layer, enabling the successful treatment of this sensitive painting for the first time in the painting’s history.
In vitro comparison between inspiration synchronized and continuous vibrating mesh nebulizer during trans-nasal aerosol delivery
Authors: Li Jie , Wu Wei , Fink James B. 
Published: January 2020

AbstractBackgroundCompared to continuous vibrating mesh nebulizer (VMN), inspiration synchronized VMN has shown increased inhaled dose during noninvasive ventilation; however, its use during aerosol delivery via high-flow nasal cannula (HFNC) is still unknown.MethodsAn adult manikin was connected to a dual-chamber model lung, which was driven by a critical care ventilator to simulate spontaneous breathing. A HFNC system was utilized with temperature at 37 ° C while gas flow at 5, 10, 20, 40, and 60 L/min. Inspiration synchronized and continuous aerosol generation were compared at different positions (at the inlet of humidifier vs close to patient). One milliliter of albuterol (2.5 mg/mL) was used in each run (n= 3). Collection filter was placed at the trachea and was removed after each run. Drug was eluted from the filter and assayed with UV spectrophotometry (276 nm).ResultsWhen nebulizer was placed close to patient, inhaled dose was higher with inspiration synchronized than continuous aerosol generation at all gas flows (p= 0.05) except at 5 L/min. When placed at the inlet of humidifier, compared to continuous, inspiration synchronized aerosol generated higher inhaled dose with gas flow set below 50% of patient inspiratory flow [23.9 (20.6, 28.3)% vs 18.1 (16.7, 19.6)%,p< 0.001], but lower inhaled dose with gas flow set above 50% of patient inspiratory flow [3.5 (2.2, 9.3)% vs 9.9 (8.2, 16.4)%,p= 0.001]. Regardless of breathing pattern, continuous aerosol delivered greater inhaled dose with nebulizer placed at humidifier than close to patient at all gas flows except at 5 L/min.ConclusionWhen the HFNC gas flow was set higher than 50% of patient inspiratory flow, no significant advantage was found in inspiration synchronized over continuous aerosol. However, inspiration synchronized aerosol generated 30% more inhaled dose than continuous with gas flow set below 50% of patient inspiratory flow, regardless of nebulizer placement. Continuous nebulizer needs to be placed at the inlet of humidifier.
Axisymmetric deformation in transversely isotropic magneto-thermoelastic solid with Green–Naghdi III due to inclined load
Authors: Kaur Iqbal , Lata Parveen 
Published: January 2020

AbstractThe axisymmetric problem in two-dimensional transversely isotropic magneto-thermoelastic (TIMT) solid due to inclined load with Green–Naghdi (GN)-III theory and two temperature (2T) has been studied. The Laplace and Hankel transform has been used to get the expressions of temperature distribution, displacement, and stress components with the horizontal distance in the physical domain. The effect of Green–Naghdi theories of type I, II, and III theories of thermoelasticity has been studied graphically on the resulting quantities. A special case for the magneto-thermoelastic isotropic medium has also been studied.
Cost-effectiveness and value of information analysis of a low-friction environment following skin graft in patients with burn injury
Authors: Kandiyali Rebecca , Thom Howard , Young Amber E. , Greenwood Rosemary , Welton Nicky J. 
Published: January 2020

AbstractBackgroundPatients with burn injuries may receive a skin graft to achieve healing in a timely manner. However, in around 7% of cases, the skin graft is lost (fails to attach to the wound site) and a re-grafting procedure is necessary. It has been hypothesised that low-friction (smooth, more slippery) bedding may reduce the risk of skin-graft loss. A before and after feasibility study comparing low-friction with standard bedding in skin-grafted patients was conducted in order to collect proof of concept data. The resulting relative risk on the primary outcome (number of patients with skin graft failure) for the non-randomised study provided no evidence of effect but had a large standard error. The aim of this study is to see if an appropriately powered randomised control trial would be worthwhile.MethodsA probabilistic decision-analytic model was constructed to compare low-friction bedding to standard care in a population of burn patients who have undergone skin grafting. Results from the before and after study were used as model inputs. The sensitivity of results to bias in the relative risk of graft loss was conducted. Low-friction bedding is considered optimal if expected incremental net benefit (INB) is positive. Uncertainty is assessed using cost-effectiveness acceptability curves. Expected Value of Perfect Partial Information (EVPPI) provides an upper bound for the potential net health benefits of new research for given model input.ResultsAt a willingness to pay threshold of £20,000 per QALY, INB = £151 (95% Credible Interval (CrI) −142 to 814), marginally favouring low-friction bedding but with high uncertainty (probability of being cost-effective 70.5%). Expected value of perfect information (EVPI) per patient was £20.29, which results in a population EVPI of £174,765 over a 10-year lifetime for the technology (based on 1000 patients per year who would benefit from the intervention). The parameter contributing most to the uncertainty was the inpatient care cost, i.e. information that could be obtained from the audit of practice and without an expensive trial. These findings were robust to a wide-range of assumptions about the potential bias due to the observational nature of the comparative evidence.ConclusionsOur study results suggest that an RCT (randomised controlled trial) is unlikely to be worthwhile, but there may be value in a study to estimate the re-graft rates and associated costs in this population.
Medicinal uses, phytochemistry and pharmacology of Ammodaucus leucotrichus
Authors: Idm’hand Elhassan , Msanda Fouad , Cherifi Khalil 
Published: January 2020

AbstractThis review summarizes selected scientific evidence on phytochemistry and pharmacological properties of Ammodaucus leucotrichus. Information was gathered via the Internet (using Scopus, PubMed, Google Scholar, Elsevier, Springer, Science Direct, Researchgate and Web of Science) as well as from libraries and local books. Ammodaucus leucotrichus (A. leucotrichus), belongs to the family Apiaceae, has been reported to possess a wide range of traditional medicinal uses including in diarrhea, cough, pulmonary diseases, anorexia, allergy, tachycardia, helminthiasis, stomach pain, gastralgias, otitis, indigestion, cold, fever, anorexia and cardiac diseases. Phytochemical investigations revealed that this plant possesses many bioactive chemical constituents including monoterpenes and their derivatives, sesquiterpenes and their derivatives, tannins, anthracenes compounds, sterols, triterpenes, reducing compounds, alkaloids, phenol acids, saponins, flavonoids and coumarins. The most important pharmacological activities are antioxidant, antibacterial, antifungal, antidiabetic, anti-inflammatory, anticholinesterase and cytotoxicity activities. Ammodaucus leucotrichus has potential for the treatment of a wide range of diseases and has been well studied for its phytochemical properties. However, further scientific studies are needed to explore mechanisms of actions, adverse effects of the extracts, toxicity and the therapeutic effect of major secondary metabolites.
Current status of surgery-first approach (part III): the use of 3D technology and the implication in obstructive sleep apnea
Authors: Jung Junho , Moon Seung-Hwan , Kwon Yong-Dae 
Published: January 2020

AbstractConsidering psychosocial needs of patients, it is not surprising that surgery-first approach (SFA) is becoming more popular than ever. Although the concept of SFA was introduced a few decades ago, the limitation of analysis method based on two-dimensional images makes surgeons reluctant to choose SFA. Recently, the advancement of three-dimensional technology allows us to perform SFA even without minimal pre-surgical orthodontic treatment, and the prediction of surgical outcome became more accurate, especially in obstructive sleep apnea (OSA) patients to whom the advantages of SFA should be more significant. Here, we describe the current trend of SFA and its implication in OSA patients.
Exploration of miRNAs in Neolamarckia cadamba and their potential cross-kingdom functions
Authors: He Jia-Jian , Ye Rui , Chen Ting , Xi Qian-Yun , Luo Jun-Yi , Zhang Hao-Jie , Wu Jia-Han , Sun Jia-Jie , Zhang Yong-Liang 
Published: January 2020

AbstractNeolamarckia cadamba (Roxb.) Bosser (Rubiaceae) is a widespread plant with medicine value and has been used for treating various diseases, such as coughs, fevers, anemia, blood disorders and stomach pains. It had been reported that plant miRNAs might enter mammalian intestines and exert a special ingredient across the different species. However, the knowledge about miRNAs in N.cadamba is scarce. In this study, we first applied high-throughput sequencing to identify miRNAs in N.cadamba. Sequencing revealed a total of 11,285,965 raw reads in the small RNA library of N.cadamba leaves. By bioinformatics analysis, we identified a total of 192 miRNAs, including 167 conserved miRNAs and 25 novel miRNAs, which were distributed among 30 families. Next, we used miRanda to predict the targets of those miRNAs in human, 4030 target genes were predicted. Furthermore, Gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that the identified miRNAs majored in binding, vibrio cholerae infection and insulin signaling, which were likely to provide valuable references for further understanding of medical functions of N. cadamba.
Building a bioelectronic medicine movement 2019: insights from leaders in industry, academia, and research
Authors:   Alliance for Advancing Bioelectronic Medicine
Published: January 2020

AbstractIn April 2019, a select group of medical, academic, and private-sector leaders in bioelectronic medicine convened in Geneva to discuss the potential for building a cross-disciplinary movement that would advance the field with key stakeholders – both those who are already active in research and commercialization as well as those who will influence the pace of development and uptake of innovative technologies and treatments. Hosted by BioSig Technologies and physicians from the Mayo Clinic, the roundtable was unique in its focus on what it will take to advance awareness of bioelectronic medicine, including a shared definition, unified narrative, and set of tailored messages to win over key audiences. The attendees developed a consensus on these issues and agreed to form a working group beyond the roundtable, which has since evolved into the Alliance for Advancing Bioelectronic Medicine. This meeting report summarizes the key insights from the roundtable, including a call to action aimed at accelerating growth and collaboration across the field.
Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes
Authors: Abioye Amos , Ayodele Oladapo , Marinkovic Aleksandra , Patidar Risha , Akinwekomi Adeola , Sanyaolu Adekunle 
Published: January 2020

AbstractΔ9-Tetrahydrocannabivarin (THCV) is a cannabis-derived compound with unique properties that set it apart from the more common cannabinoids, such as Δ9-tetrahydrocannabinol (THC). The main advantage of THCV over THC is the lack of psychoactive effects. In rodent studies, THCV decreases appetite, increases satiety, and up-regulates energy metabolism, making it a clinically useful remedy for weight loss and management of obesity and type 2 diabetic patients. The distinctions between THCV and THC in terms of glycemic control, glucose metabolism, and energy regulation have been demonstrated in previous studies. Also, the effect of THCV on dyslipidemia and glycemic control in type 2 diabetics showed reduced fasting plasma glucose concentration when compared to a placebo group. In contrast, THC is indicated in individuals with cachexia. However, the uniquely diverse properties of THCV provide neuroprotection, appetite suppression, glycemic control, and reduced side effects, etc.; therefore, making it a potential priority candidate for the development of clinically useful therapies in the future. Hopefully, THCV could provide an optional platform for the treatment of life-threatening diseases.
How EU-funded Smart City experiments influence modes of planning for mobility: observations from Hamburg
Authors: Späth Philipp , Knieling Jörg 
Published: January 2020

AbstractHamburg participates in the EU-funded research and development project mySMARTlife (mSL) with experiments involving smart city technologies, among others in the field of transportation infrastructure. These experiments are shaped by a public-private consortium in accordance with a call of the EU research and innovation program “Horizon 2020”. They focus on close to the market technologies. The experiments aim at citizen participation. Yet, what technologies are experimented with has been decided and contractually fixed by the consortium beforehand. We explore tensions in this kind of setup, and how entrenched approaches to planning of transportation infrastructure are challenged by new subjectivities, expectations, standards and procedures. From our perspective, it is highly questionable whether a purely expert driven process can produce outcomes that sufficiently reflects local residents’ ideas of sustainable and appropriate changes to urban infrastructures. For this reason, candidate ‘solutions’ for future mobility demands should be exposed to societal deliberation at an earlier stage in their development.Our exploration of (possible) interplays between such an experimental approach to the shaping of infrastructures and the pre-existing integrated approach to planning has been a modest first step, and more empirical research would be needed to draw solid conclusions. It seems worthwhile to analyse more deeply the in- and exclusiveness of the actor constellations in such processes, the role of coincidences or strategies behind the selection of partners, and a possible gate-keeper function of the process initiator.
Abdallah Hammadi, Dīwān maŷalla Hunā al-Ŷazā’ir, Argel, Dār Bahā’ al-Dīn, 2019 [ISBN 987-9931-342-42-9]
Authors: Torres Fernández Antonio 
Published: January 2020

Reseña de: Dīwān maŷalla Hunā al-Ŷazā’irpor: Antonio Torres Fernández
Gardner Syndrome imaging features in plain radiographs and computed tomography: a case report
Authors: Munhoz Luciana , IIda Christyan Hiroshi , Arita Emiko Saito , Watanabe Plauto Christopher Aranha 
Published: January 2020

Gardner syndrome (GS) is a genetic disease with high penetrance characterized by a signal triad of colonic polyposis, multiple osteomas and mesenchymal tumors in the soft tissues and skin. The colonic polyposis is associated to the development of malignant disease. Patients also may present maxillomandibular alterations such as impacted teeth, supernumerary teeth, congenital missing teeth and odontomas. Bone lesions and maxillomandibular alterations usually precedes the gastrointestinal alterations; hence dentists should be aware of GS syndrome main radiographic signals , in order to detect the disease and proper referred the patient to medical treatment and surveillance. Thus, in this report, it is demonstrated a case of GS in a male patient, as well as discussed GS features.