bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unmet Medical Care Needs Due To Payment Difficulty
Authors: TERZİ Melek , Kurutkan Mehmet Nurullah , Şahin Dilek , Kara Oğuz 
Published: July 2020

Abstract
Objective: This study aims to determine the effects of chronic diseases and socio-economic factors on payment difficulty in medical care.Methods: The variables used in the analysis were obtained from the “2016 TURKSTAT Health Survey” micro data set. Three models were established to determine the degree of chronic disease data and socio-economic variables affecting the payment difficulty in medical care. Binary Logit Regression analysis was used to analyze the models.Findings: In terms of payment difficulty in medical care; age, education, household income, social security institution (SGK) treatment cost, general health insurance (GSS) treatment cost, other treatment cost, reason for not working, work continuity, working method, overall health status, being sick longer than 6 months, vital activity restriction, asthma, bronchitis, coronary heart failure, arthrosis, waist and neck disorders, allergy, liver failure, kidney disease, depression, other chronic diseases, wearing glasses, physical pain state, pain preventing life, feeling worthless, receiving bed service for the last 12 months, receiving daily service for the last 12 months, drug use by his own decision, cholesterol measurement status, blood glucose measurement status, stool occult blood test measurement status, being late for appointment, payment difficulty in dental care, in drug and in spiritual treatment, tobacco use status and exposure to tobacco smoke were effective (p<0,05). According to Cohen d, the groups with the strongest effect on payment difficulty in medical care are payment difficulty in dental care, drug and spiritual treatment, delay due to transportation, depression and chronic bronchitis (E.B. > 0,8).Conclusions: According to the results of the research, it was determined that chronic diseases and socio-economic variables are effective in the payment difficulty of medical care. Policymakers can benefit from evidence-based on econometric models of the comparative burden of different chronic conditions, demographic and economic structure.
Designing and Psychometric of Reproductive Health Related Behaviors Assessment Tool in Iranian males: An Exploratory Mixed Method Study Protocol
Authors: Geranmayeh Mehrnaz , Zareiyan Armin , Moghadam Zahra Behboodi , Mirghafourvand Mojgan , Sanaati Foziye 
Published: July 2020

Abstract
Background: Male reproductive health is a relatively new concept, and most men are neglected in reproductive health discussions. Therefore, it appears that there is insufficient information about the male reproductive health. This study aims to design a psychometric instrument for assessing the male reproductive health-related behavior.Methods/design: This is a sequential exploratory mixed-method study with a classical instrument development design. It will be conducted in two qualitative and quantitative phases on the studied units including the men living in Tehran. In the first phase, a qualitative study of a contractual content analysis approach will be conducted in order to perceive the concept of male reproductive health-related behavior, determine the dimensions of the questionnaire, and explore the items. In the second phase, a quantitative study will be carried out to evaluate the psychometric properties as well as (form, content, and construct) validity and reliability of the instrument designed in the first phase. Finally, the instrument will be scored and interpreted.Discussion: Discovering men’s perception of concept of reproductive health-related behavior can help design a valid and reliable questionnaire which can be used in studies evaluating the male reproductive health-related behavior.Ethical Code: IR.TUMS.FNM.REC.1397.157
Construction and Investigation of a circRNA-Associated ceRNA Regulatory Network in Tetralogy of Fallot
Authors: Yu Haifei , Wang Xinrui , Cao Hua 
Published: July 2020

Abstract
Background: As the most frequent type of cyanotic congenital heart diseases (CHD), Tetralogy of Fallot (TOF) has a relatively poor prognosis without the corrective surgery. Circular RNA (circRNA) represents a novel class of endogenous noncoding RNAs that regulate target gene expression post-transcriptionally in heart development. Here, we investigate the potential role of ceRNA network in the pathogenesis of TOF. Methods: To identify circRNAs expression profiles in Tetralogy of Fallot, microarrays were used to screen the differentially expressed circRNA between 3 TOF and 3 control human myocardial tissue samples. Then, a dysregulated circRNA- associated ceRNA network was constructed via using the established multi-step screening strategy.Results: In summary, total 276 differentially expressed circRNAs were identified, including 214 up-regulated and 62 down-regulated ones in TOF samples. By constructing the circRNA-associated ceRNA network based on the bioinformatics data, a total of 19 key circRNAs, 9 key miRNAs and 34 key mRNAs were further screened. Moreover, by enlarging the samples size, the qPCR results validated that the positive correlations between hsa_circ_0007798 and HIF1A.Conclusions: The findings in this study provide a comprehensive understanding of the ceRNA network involved in TOF biology, such as hsa_circ_0007798/miR-199b-5p/HIF1A signal axis, and may offer candidate diagnostic biomarkers or potential therapeutic targets for TOF. In addtion, we propose that the ceRNA network regulates TOF progression.
Hypertension and the effect of dietary salt on inflammation: An interventional study
Authors: Masenga Sepiso Kenias , Pilic Leta , Hamooya Benson M. , Nzala Selestine , Kwenda Geoffrey , Heimburger Douglas C. , Mutale Wilbroad , Koethe John R. , Kirabo Annet , Munsaka Sody M. 
Published: July 2020

Abstract
ObjectiveHypertension and dietary salt are associated with inflammation in murine models. Studies in humans are scare and yet critical for the prevention and treatment of hypertension. This was an interventional study of 85 participants. Participants were instructed to follow a one week of low (4 g/day)- and high (9 g/day)-salt diet. BioLegend’s LEGENDplex™ bead-based immunoassay (USA) was used to quantify cytokine levels in plasma. Mann-Whitney, logistic regression and the Wilcoxon matched-pairs signed-rank test were used to compare inflammation markers on low- and high-salt diets. The goal of this study was to determine the association between hypertension and inflammation and the effect of high dietary salt intake on pro- and anti-inflammatory cytokines in HIV positive and HIV negative individuals.Results43 participants among the 85 were hypertensive with equal sex distribution. Hypertensives had higher plasma levels of IL-6, IL-17A, tumor necrosis factor-alpha, monocyte count and fasting blood glucose. High salt intake was associated with higher IL-2 in hypertensive persons with HIV and lower IL-21 plasma levels in the HIV-negative. These findings suggest that there is an association between hypertension, salt and inflammation. Hypertension is associated with inflammation, and dietary salt intake may play a role in modulating inflammation.RegistrationPan African Clinical Trial Registry (www.pactr.org) PACTR202007493610166. Retrospectively registered.
The Outcomes of a Person-centered, Non-Pharmacological Intervention in Reducing Behavioral and Psychiatric Symptoms in Residents With Advanced Dementia in Australian Rural Nursing Homes
Authors: Isaac Vivian , Kuot Abraham , Hamiduzzaman Mohammad , Strivens Edward , Greenhill Jennene 
Published: July 2020

Abstract
BackgroundThere is limited best- practice evidence to address behavioral and psychiatric symptoms for those with advanced dementia in Australian rural nursing homes. This study aims to evaluate the outcomes of a person-centered, non-pharmacological dementia care model, ‘Harmony in the Bush’, based on the Progressively Lowered Stress Threshold principles and person-centered music in rural Australia.MethodsA quasi-experimental study was conducted in five rural nursing homes in Queensland and South Australia. Seventy-four residents with advanced dementia participated in this intervention study, which yielded a sample power of 80%. Eighty-seven staff completed the Caregiver Stress Inventory at pre-post four-weeks of intervention. Staff training workshops focusing on the theory and delivery of the Progressively Lowered Stress Threshold principles and a music intervention. We used reported changes in agitation of the residents, measured using Cohen- Mansfield Agitation Inventory, and staff’s caregiving stress, using Caregivers Stress Inventory. Triangulation using post- intervention qualitative evaluation from 13 focus group discussion and 38 staff interviews. This study adheres to the CONSORT guidelines.ResultsMean age of residents with advanced dementia was 82.4 (7.7) years and 69% were females. The mean age of admission was 80.1(8.4) years. Baseline measures indicated that 32.7% had mild- severe pain and 30.5% reported mild-severe sadness. The results showed statistically significant decline in aggressive behaviors, physically non-aggressive behaviors, verbally agitated behavior and hiding and hoarding. There was comparable reduction in staff stress in the domains of aggressive behaviors, inappropriate behaviors, resident safety, and resource deficiency.ConclusionsThe Harmony in the Bush model is effective in reducing behavioral and psychiatric symptoms in advanced dementia with significant reduction in staff stress levels in nursing homes in rural Australia.Trial Registration: Australian and New Zealand Clinical Trials Registry (ANZCTR) on 20/2/2018 (Registration No: ACTRN12618000263291p). https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374458
The Value of Enhanced Three-dimensional Brain volume magnetic Resonance Imaging in tolosa-hunt Syndrome: A Clinical Retrospective Study
Authors: Lin Guoliang , Zhang Shushu , Hu Beilei , Chen Songfang , Zou Ming , Gong Yuqiang , Cheng Bihuan , He Zhiyong 
Published: July 2020

Abstract
Background: The study aimed to evaluate the enhanced three-dimensional brain volume magnetic resonance imaging (3D-BRAVO) in the diagnosis of Tolosa-Hunt syndrome (THS). Methods: we described 21 patients with THS and their case records including clinical syndromes and neuroradiologic features by conventional MRI and enhanced 3D-BRAVO. Results: 19 patients showed enhancement in the cavernous sinus through 3D-BRAVO. 16/19had ipsilateral enhanced lesions involved 4-10 continuous slices in cavernous sinus on 3D-BRAVOscan. Both local size enlargements and enhancement in the cavernous sinus were found in 3 patients. The rest 2 patients performed negative results on neither conventional MRI nor enhanced 3D-BRAVO. Conclusions: enhanced 3D-BRAVO imaging demonstrated a high detection rate in the cavernous sinus, which may promote our understanding ofTolosa-Hunt syndrome.
CD8+ T Cells in the Central Nervous System of Mice With Herpes Simplex Infection are Highly Activated and Express High Levels of CCR5 and CXCR3
Authors: Lind Liza , Svensson Alexandra , Thörn Karolina , Krzyzowska Malgorzata , Eriksson Kristina 
Published: July 2020

Abstract
Background: Herpes simplex virus type 2 (HSV-2) is a neurotropic virus that can cause meningitis, an inflammation of the meninges in the central nervous system. T cells are key players in viral clearance, and these cells migrate from peripheral blood into the central nervous system upon infection. Several factors contribute to T cell migration, including the expression of chemokines in the inflamed tissue that attract T cells through their expression of chemokine receptors. Here we investigated CD8+ T cell profile in the spinal cord in a mouse model of herpes simplex virus type 2neuroinflammation. Method: Mice were infected with HSV-2, and sacrificed when showing signs of neuroinflammation. Cells and/or tissue from spinal cord, spleen and bloodwere analyzed for viability, expression of activation markers, chemokinereceptors and chemokines. Statistics were calculated using students T test and one-way ANOVA.Results:High numbers of CD8+ T cellswere present in thespinal cord following genital HSV-2-infection.CD8+T cells were highly activated and HSV-2 glycoprotein B -specific effector cells, some of which showed signs of recent degranulation. They also expressed high levels of many chemokine receptors, in particular CCR2, CCR4, CCR5 and CXCR3. Investigating corresponding receptor ligands in spinal cord tissue revealed markedly increased expression of the cognate ligands CCL2, CCL5, CCL8,CCL12 and CXCL10. Conclusion: This study shows thatduring herpesvirus neuroinflammation anti-viralCD8+T cells accumulatein the CNS. CD8+ T cells in the CNS also express chemotactic receptors cognate to the chemotactic gradients in the spinal cord. This indicates that anti-viral CD8+ T cells may migrate to infected areas in the spinal cord during herpesvirus neuroinflammation in response to chemotactic gradients.
Clinical effectiveness of metacognitive training as a transdiagnostic program in routine clinical settings: A single-group pre-post study
Authors: Tanoue Hiroki , Yoshinaga Naoki , Hayashi Yuta , Ishikawa Ryotaro , Ishigaki Takuma , Ishida Yasushi 
Published: July 2020

Abstract
Objective

To evaluate the clinical effectiveness of metacognitive training (MCT) as a transdiagnostic program, on a diverse population with mental disorders in routine day-care settings through a single-group pre-post-design.
Results

Thirty-four participants diagnosed with various mental disorders (schizophrenia = 22, non-schizophrenia = 12) received ten MCT group-sessions. Intent-to-treat analyses revealed significant improvements in quality of life/global functioning during the intervention period, and these improvements were well-maintained during the follow-up (all p < 0.05). The baseline to follow-up treatment effect sizes for quality of life and global functioning were middle (Hedge's g = 0.44 and 0.47, respectively). Significant improvements were also found in depressive symptoms during both the intervention and follow-up periods (all p < 0.05), but not in cognitive insight. Overall, participants were highly satisfied with the MCT content and format. Scores on almost all outcomes (except for depression) at each assessment point were not significantly different between the schizophrenic and non-schizophrenic sub-groups. The findings of this study suggest that MCT for a diverse population with mental disorders is a potentially effective approach in improving quality of life/global functioning and other clinical outcomes in routine day-care settings.
Trial Registration:

UMIN-CTR, UMIN000032393 (registered on April 26, 2018)
Genome-Wide Profiling and Clinical Significance of Alternative Splicing Events in Glioblastoma
Authors: Ren Xiufang , Liu Tianqi , Chen Xin , Guan Gefei , Zou Cunyi , Guo Qing , Cheng Peng , Xu Xiaoyan , Cheng Wen , Zhu Chen , Wu Anhua 
Published: July 2020

Abstract
Aims: The purpose of this study was to depict alternative splicing (AS) profiles in GBM and identify their clinical significance in the progression of GBM. Materials and Methods: RNA sequence data and clinical information were downloaded from The Cancer Genome Atlas portal (https://portal.gdc.cancer.gov/projects). Genome-wide alternative splicing events were obtained using SpliceSeq tool. Analyses were performed using GraphPad Prism 7 and R software. Key findings: Univariate Cox analysis identified 2406 AS events with prognostic significance. We built an interaction network based on these survival-related AS events. Unsupervised clustering analysis showed that patients in cluster 2 had a better prognosis than those in other clusters. The prognostic splicing factors and AS events were used to generate a splicing network. Seven prognostic signatures, developed based on the top three survival-related AS events, predicted the survival risk and may serve as independent indicators of unfavorable prognosis. Among these risk signatures, only the alternate promoter (AP) signature was upregulated in the mesenchymal subtype, which is characterized by a complex immune microenvironment. A high AP risk score indicated an overloaded local immune response and enriched immune cell infiltration, which may accelerate the progression of GBM.Significance: AS-related signatures may serve as predictors of prognosis as well as provide treatment targets and guidance for GBM patients.
A Series of Frustrations of Fever for Congenital Heart Disease: Case Report
Authors: Dai Cong , Yu Jian-Hua , Tang Yan-Hua , Yang Ren-Qiang 
Published: July 2020

Abstract
Background: Fever, dry cough and fatigue are the most common symptoms of the coronavirus disease-2019 (COVID-19). During the COVID-19 pandemic in China, we treated a patient with fever and finally diagnosed congenital heart disease.Case presentation: An 18-year-old lady came to the fever clinic with a complaint about the symptoms of fever, dry cough and dyspnea for 15 days. She had a travel history of epidemic area two weeks ago. She had a low fever and dry cough accompanied with chest tightness and fatigue. Eventually she diagnosed ventricular septal defect complicated by infective endocarditis. Two months after surgery, the patient returned to normal social life and physical activity.Conclusion: Early surgical treatment is an effective strategy for ventricular septal defect patients complicated with IE, which can improve the early survival rate of patients.
Lattice Vibrational Characteristics and Structures-Properties Relationships of Non-Stoichiometric Nd[Mg0.5Sn0.5(1+x)]O3 Ceramics
Authors: Shi Feng , xiao en-cai , Lei Wen , Chen Guohua , Chen Ying 
Published: July 2020

Abstract
Non-stoichiometric Nd[Mg0.5Sn0.5(1+x)]O3 (-0.04 ≤ x ≤ +0.04) - type samples were prepared using a traditional two-step solid-state sintering process. Their crystal structures, phase compositions, dielectric properties and lattice vibrational characteristics were identified in detail. Double perovskite Nd(Mg0.5Sn0.5)O3 with a monoclinic structure was distinguished as the main crystalline phase, pure phase was obtained when x < 0, and the sample [Nd(Mg0.5Sn0.49)O3] at x = -0.02 shows the excellent dielectric properties: εr = 18.74, Q × f = 47,979 GHz. Lattice vibrational characteristics were clarified with Raman and infrared active modes assigned and illuminated, accurately. The intrinsic properties were fitted by four-parameter semi-quantum model, which show that the low-frequency infrared modes yield a more significant contribution to permittivity and dielectric loss. Raman shifts of modes F2g(A) and F2g(B) correlate with dielectric constants negatively, which implies that the bond length has a positive correlation with permittivity. Full widths at half maximum of vibritional modes A1g(O) correlate with dielectric loss values positively and correlate with the degree of order (S) negatively.
Epidemiological and Clinical Features of Imported and Local Patients with Coronavirus Disease 2019 (COVID-19) in Hainan, China
Authors: Wu Biao , Lei Zi-Ying , Wu Kun-Liang , He Jian-Rong , Cao Hui-Juan , Fu Juan , Chen Feng , Chen Yuan , Chen Bao , Zhou Xiao-Li , Huang Tao , Wu Tao , Du Yong-Guo , Chen Suo-Xian , Xiao Fu-Rong , Gao Zhi-Liang , He Jing , Lin Feng , Lin Bingliang 
Published: July 2020

Abstract
Background: Hainan Island, a popular tourist destination, had received many imported cases of Coronavirus disease 2019 (COVID-19), but successfully contained the epidemics in one month. We described epidemiological and clinical characteristics of COVID-19 in Hainan and compared these features between imported and local cases to provide information for other international epidemic areas.Methods: We included 91 patients (56 imported and 35 local cases) from two designed hospitals for COVID-19 in Haikou, China, from January 20 to February 19, 2020. Data on demographic, epidemiological, clinical and laboratory characteristics were extracted from medical records. Patients were followed up until April 21, 2020, the levels of antibodies in the follow-up were also analyzed.Results: Of the 91 patients, 78 (85.7%) patients were diagnosed within the first three weeks after the first case identified (Day 1: Jan 22, 2020), while the number of local cases started to increase from the third week. No new cases occurred after Day 29. Fever and cough were two main clinical manifestations. 15 (16.5%) were severe, 14 (15.4%) had complicated infections, nine (9.9%) were admitted to ICU, and three died. Median duration of viral shedding in feces was longer than that in nasopharyngeal swabs (19 days vs 16 days, P=0.007). Compared with local cases, imported cases were older, have higher incidence of fever and concurrent infections. There was no difference in outcomes between the two groups. IgG was positive in 92.8% patients (77/83) in the follow-up of week 2 after discharge, 88.4% patients (38/43) had a reduction in IgG levels in the follow-up of week 4 after discharge, and the median level was lower than that in the follow-up of week 2 (10.95 S/CO vs 15.02 S/CO, P<0.001)Conclusion: Imported cases were more severe than local cases, but could have similar prognosis. The level of IgG antibodies declined from week 6 to week 8 after onset. The short epidemic period in Hainan suggests that the epidemics could be quickly brought under control if proper timely measures were taken.
Isoperistaltic versus antiperistaltic uncut Roux-en-Y anastomosis after distal gastrectomy for gastric cancer: A propensity score matched analysis.
Authors: hangtian cui , Huabing Huang , Tianhang Luo , Xiaoyi Yin , Guoen Fang 
Published: July 2020

Abstract
Background
The uncut Roux-en-y anastomosis (URYA) has some clinical advantages after distal gastrectomy (DG). Little evidence exists regarding the influence of peristalsis on this anastomosis. We aimed to evaluate short-term outcomes of isoperistaltic URYA (iso-URYA) comparing with antiperistaltic URYA (anti-URYA) after DG.
Method:
Patients who underwent URYA for gastric cancer (GC) between January 2016 and December 2018 were selected from Shanghai Changhai Hospital, Navy Medical University. Short-term outcomes were compared between iso-URYA group and anti-URYA group after 1: 1 propensity score matching (PSM).
Result
A total of 612 patients were selected. 392 patients underwent iso-URYA and 220 patients underwent anti-URYA. After PSM, 183 patients for each group were included in the final analysis. No differences were found between them in terms of short-term complications,nutritional status and quality of life one year after surgery. Endoscopic examination showed that anti-URYA group had more severe gastritis (P = 0.036). In addition, the recanalization rate was significantly higher when the afferent loop was blocked by stapler.
Conclusion
The iso-URYA and anti-URYA group present similar results in short term outcomes. Ligation blocking afferent loop leads to lower recanalization rate.