bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroplasty versus internal fixation for intertrochanteric fractures in the elderly: A meta-analysis
Authors: Yu Kexiao , Lu Weizhong , Xiao Qiuke , Wan Ruijie , Dong Lujue , Dai Zhenyu 
Published: April 2020

Abstract
Background

Surgical treatment is the first choice for intertrochanteric fractures in the elderly as it allows early rehabilitation and functional recovery. Recently, more and more surgeons prefer arthroplasty instead of internal fixation in the treatment of senile intertrochanteric fractures. However, there is conflicting evidence as to which is the best surgical treatment for them. In this article, we performed a systematic review and meta-analysis to compare the clinical effectiveness of internal fixation (IF) and arthroplasty (AR) for intertrochanteric fractures in the elderly.
Methods

The online databases of PubMed, Cochrane Database, and Web of Science were searched to include studies conducted from 01/01/2000 to 11/30/2018 in English using keywords to identify articles relevant to this study. All studies had to have evaluated the treatment of patients with intertrochanteric fractures in the elderly(≥ 60 years of age). The quality of the trials was assessed and meta-analyses were conducted using the Cochrane Collaboration’s RevMan 5.3 version.
Results

A total of 14 studies involving a total of 1588 patients were suitable for inclusion in this meta-analysis. There was no significant difference between the IF and AR groups for postoperative complications-related general condition (OR = 1.24; 95% CI = 0.90, 1.70; P = 0.19), hospital stay (SMD = 0.16; 95% CI= -0.5, 0.82; P = 0.64), and Harris hip score (SMD= -0.12; 95% CI= -0.79, 0.54; P = 0.71). AR group had a significantly lower rate of complications-related operation (OR = 2.21; 95% CI = 1.41, 3.45; P = 0.0005) and reoperation (OR = 2.74; 95% CI = 1.57, 4.76; P = 0.0004). However, compared with AR group, IF group could reduce the blood loss (OR=-4.08; 95% CI=-4.58, -3.59; P < 0.00001), transfusion requirement (SMD= -0.67; 95% CI= -1.08, -0.26; P = 0.001), operation time (SMD= -0.80; 95% CI= -1.47, -0.12; P < 0.00001), and have a lower rate of mortality within 1-year (OR = 0.67; 95% CI = 0.52, 0.86; P = 0.002).
Conclusion

AR is associated with less rates of complications-related operation and reoperation but has an increased risk of blood loss, transfusion, operation time and mortality within 1-year. Our findings demonstrated that AR does not have significant advantages over IF for intertrochanteric fractures in the elderly.
Transcutaneous auricular vagal nerve stimulation inhibits P2X7R expression in limbic brain regions and reverses depression-like behavior in Zucker diabetic fatty rats
Authors: Yu Yutian , He Xun , Wang Yu , Zhang Jinling , Tang Chunzhi , Rong Peijing 
Published: April 2020

Abstract
Background

Previous studies confirmed that Zucker diabetic fatty rats (ZDF, fa/fa) develop type 2 diabetes (T2D) with depression-like behavior innately, and transcutaneous auricular vagal nerve stimulation (taVNS) was found to have anti-diabetic and anti-depressive effect in ZDF rats. However, there is still a lack of molecular-biological evidence that ZDF rats are a good rodent model of depression, and how does taVNS take the anti-depressive effect to the ZDF rats. P2 × 7R, a purinergic receptor most-related to inflammation and depression, is found to be elevated in depressed brains and is gradually considered as a potential therapeutic target for depression.
Methods

We deployed taVNS and transcutaneous none vagal nerve stimulation (tnVNS) to ZDF rats. We applied forced swimming test (FST) to evaluate to the depression-like behavior of the rats. We used Western blot to test the P2 × 7R expression in the hypothalamus, amygdala, hippocampus, prefrontal cortex, and cingulate cortex of the rats. Furthermore, we used immunohistochemical staining to colocalize the P2 × 7R expressing cells in the ZDF rats’ brains.
Results

We found that compared with their lean littermates (ZL rats), naïve ZDF rats developed depression-like behavior innately with elevated P2 × 7R expression in their limbic brain regions (hypothalamus, amygdala, hippocampus, prefrontal cortex, and cingulate cortex); and taVNS but not tnVNS inhibited the P2 × 7R expression in their limbic brain regions and reversed the depression-like behavior. Moreover, P2 × 7R was found majorly expressing in astrocytes and microglia of ZDF rats.
Conclusions

ZDF rats are a good rodent model of depression, and taVNS plays an anti-depressive effect in ZDF rats by inhibiting glial P2 × 7R expression in their limbic brain regions.
Applying Random Forest Model Algorithm to GFR estimation
Authors: Liu Peijia , Yang Dong , Li Shaomin , Chong Yutian , Li Ming , Hu Wentao , Wang Bohan , Liu Xiang , Liu Xun 
Published: April 2020

Abstract
Background

The utilization of estimating-GFR equations is critical for kidney disease in the clinic. However, the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has not improved substantially in the past eight years. Here we hypothesized that random forest regression(RF) method could go beyond revised linear regression, which is used to build the CKD-EPI equation
Methods

1732 participants were enrolled in this study totally (1333 in development data set from Tianhe District and 399 in external data set Luogang District). Recursive feature elimination (RFE) is applied to the development data to select important variables and build random forest models. Then same variables were used to develop the estimated GFR equation with linear regression as a comparison. The performances of these equations are measured by bias, 30% accuracy, precision and root mean square error(RMSE).
Results

Of all the variables, creatinine, cystatin C, weight, body mass index (BMI), age, uric acid(UA), blood urea nitrogen(BUN), hematocrit(HCT) and apolipoprotein B(APOB) were selected by RFE method. The results revealed that the overall performance of random forest regression models ascended the revised regression models based on the same variables. In the 9-variable model, RF model was better than revised linear regression in term of bias, precision ,30%accuracy and RMSE(0.78 vs 2.98, 16.90 vs 23.62, 0.84 vs 0.80, 16.88 vs 18.70, all P < 0.01 ). In the 4-variable model, random forest regression model showed an improvement in precision and RMSE compared with revised regression model. (20.82 vs 25.25, P < 0.01, 19.08 vs 20.60, P < 0.001). Bias and 30%accurancy were preferable, but the results were not statistically significant (0.34 vs 2.07, P = 0.10, 0.8 vs 0.78, P = 0.19, respectively).
Conclusions

The performances of random forest regression models are better than revised linear regression models when it comes to GFR estimation.
Analysis of BRCA1 large genomic rearrangements to identify individuals at risk of breast cancer
Authors: García-Magallanes Noemí , Martínez-Camberos Alejandra Paola , Leal-León Emir Adolfo , Picos-Cárdenas Verónica Judith , Romo-Martínez Enrique Johathan , Luque-Ortega Fred , García-Alvarez Edith Eunice , Barbosa-Jasso María del Pilar , Contreras-Gutierrez José Alfredo , Meraz Eliakym Arámbula 
Published: April 2020

Abstract
Background. Breast cancer (BC) is a malignant neoplasm in which genetic and environmental aspects contribute to its development. In many cases, pathogenic mutations in BRCA1 are caused by large genomic rearrangements such as copy number variations, a mechanism of gene inactivation that increases the risk of BC. Therefore, identifying women at high risk of BC through genetic testing is of great importance. This study aimed to identify large BRCA1 rearrangements in patients with early-onset or family history of BC. Methods. Peripheral blood from patients with (n= 38) and without (n= 30) BC was analyzed using the multiplex ligation-dependent probe amplification assay to detect large genomic rearrangements in BRCA1. Results. One patient with sporadic BC showed an ambiguous deletion in exon 12 of the BRCA1 gene. To validate this result, full sequencing of this region was performed. The mutation detected by MLPA resulted in a false positive, showing that large genomic rearrangements in BRCA1 were absent in all subjects. Moreover, in this same patient, we detected the presence of c.4308T>C (rs1060915) polymorphism. Conclusions. In our patients with BC, large genomic rearrangements in BRCA1 are held unaccountable for the development of the disease. We identified the presence of single nucleotide polymorphism, c.4308T>C (rs1060915), in a patient with sporadic BC.
Cadmium uptake, translocation, and redistribution affect Cd accumulation in grain of common wheat (Triticum aestivum L.) cultivars
Authors: Cheng Yiran , Zhang Xu , Wang Sha , Xiao Xue , Zeng Jian , Kang Houyang , Fan Xing , Sha Lina , Zhang Haiqin , Zhou Yonghong , Wang Yi 
Published: April 2020

Abstract
Background

To study the cadmium (Cd) accumulation in wheat grain, we evaluated the grain Cd concentrations of 46 common wheat cultivars grown at two sites in Sichuan, China and selected five different grain Cd accumulators (a high-Cd accumulator ZM18, four low-Cd accumulators YM51, YM53, SM969 and CM104) to explore the physiological processes of Cd accumulation in the grain of wheat grown under varying degrees of Cd stress.
Results

Our results showed that the Cd concentration in grain differed among genotypes. Under low-Cd stress, the grain Cd concentration was correlated with the Cd translocation factor (TF) of roots to grain and all the Cd redistribution factors (RFs). Compared with the ZM18, the cultivars YM53 and SM969 accumulated less Cd in the grain due to low Cd redistribution from lower stems and older leaves to grain. The low-Cd accumulators YM51 and CM104 were due to low Cd transport from roots to grain, and low Cd redistribution from glumes, flag leaves, lower stems, and older leaves to grain. Under high-Cd stress, the ZM18, YM53, and SM969 accumulated significantly more Cd in the grain, root and other tissues than did YM51 and CM104. Correlation analyses showed that the grain Cd concentration of wheat under high Cd stress was positively correlated with the Cd concentration in each tissue and the TFs of roots to grains, rachis, internode 1 and flag leaves.
Conclusions

Cd translocation directly from roots to grain and Cd redistribution from shoots to grain determines the Cd accumulation in grain of wheat cultivars under low-Cd stress. Cd uptake by root and then synchronously transported to new shoots determined the differences of Cd accumulation in the grain of wheat cultivars under high Cd stress.
Hypertension management based on general practice care in Shanghai, China
Authors: Luo Xiaoli , Huang Yimin , Zheng Yongtao , Wang Lichao , Li Jue , Zhang Lijuan 
Published: April 2020

Abstract
Background

Hypertension is one of the major public health problems in China. General practice (GP)-based disease management programs including hypertension have been widely disseminated in communities of Shanghai since 2010. This study was to evaluate the effectiveness on GP-management profile among patients with hypertension in urban communities of Shanghai, China.
Methods

A retrospective, community-based study using a primary care database from 2015 to 2017 was performed. The annual effective management of hypertension (≥ 4 times follow-up per year), blood pressure (BP) control rates, drug interventions, comorbidities burden were analyzed, respectively. Logistic regression analysis was used to determine the association between factors and uncontrolled BP.
Results

From 2015 to 2017, the effective management rate increased from 83.6–95.1%. Among them, drug treatment rates and BP control rates displayed a growing trend (P༜0.001), reached 94.1% and 80.6% in 2017, respectively. The medication of antihypertensive drugs was dominated by calcium channel blocker (CCB) and angiotensin receptor blocker (ARB) categories. Of the 8105 patients registered in 2015, 31.0% cases developed new comorbidities in the following two-years. Totally, comorbidities were present in 46.9% patients in 2017. Age, body mass index, combined medication, history of stroke and kidney damage were independently related to uncontrolled BP.
Conclusions

Although the rate of treatment and control of hypertension were higher in Shanghai than average of country in a community population, the comorbidities accompanied by hypertension was still far from being satisfactory. Future efforts to promote GP and optimize management strategies are needed to improve the current status.
Early Drop in Systolic Blood Pressure and Worsening Renal Function in Elderly Patients With Acute Heart Failure: How Does the Heart Rate Interact?
Authors: Takeuchi Makoto , Nagai Michiaki , Dote Keigo , Kato Masaya , Oda Noboru , Kunita Eiji , Kagawa Eisuke , Yamane Aya , Kobayashi Yusuke , Shiota Haruko , Osawa Ayano , Kobatake Hiroshi 
Published: April 2020

Abstract
Background: Regardless of patients' baseline renal function, worsening renal function (WRF) during hospitalization is associated with poor outcomes. In individuals with acute heart failure (AHF), one predictor of WRF is an early drop in systolic blood pressure (SBP). Few studies have investigated WRF in elderly AHF patients or the influence of these patients' at-admission heart rate (HR) on the relationship between an early SBP drop SBP and the AHF. Methods: We measured the SBP and HR of 245 elderly AHF inpatients (82.9±6.0 years old, females 50.6%) at admission and another six times over the next 48 hr. We defined 'WRF' as a serum creatinine increase ≥0.3 mg/dL by Day 5 post-admission. We calculated the 'early SBP drop' as the difference between the admission SBP value and the lowest value during the first 48 hr of hospitalization. Results: There were significant differences between the 36 patients with WRF and the 209 patients without WRF: early SBP drop (51.3 vs. 32.5 mmHg, p<0.01) and at-admission HR (79.3 vs. 89.6 bpm, p<0.05), respectively. In the multiple logistic regression analysis adjusted for the confounders, early SBP drop (OR: 1.003, 95%CI: 1.003–1.03, p<0.04) and HR at-admission (OR: 0.98, 95%CI: 0.96–0.99, p<0.01) were significantly associated with WRF. No significant association was shown for the interaction term of early SBP drop ´ at-admission HR with WRF (p=0.3). Conclusions: In these elderly AHF patients, exaggerated early SBP drop and lower at-admission HR were significant independent predictors of WRF, and these factors were additively associated with WRF.
Supporting Australian Clinical Learners in a Collaborative Clusters Education Model: A Mixed Methods Study
Authors: de Mortel Thea van , Armit Lyn , Shanahan Brenton , Needham Judith , Brown Candy , Grafton Eileen , Havell Michelle , Henderson Amanda , Grealish Laurie 
Published: April 2020

Abstract
Background: Nursing student numbers have risen in response to projected registered nurse shortfalls, increasing numbers of new graduates requiring transitional support and pressure on clinical placements. A Collaborative Clusters Education Model, in which Entry to Practice facilitators coach ward-based registered nurses to support students’ and new graduates’ learning, may address placement capacity. The research aim was to evaluate the acceptability of the Collaborative Clusters Education Model to stakeholders by examining their perceptions of the facilitators and barriers to the model in its implementation. Methods: A convergent mixed methods evaluation approach was adopted. The study took place in a large Australian health service in south-east Queensland. Participants included Bachelor of Nursing students, Entry to Practice facilitators, ward-based registered nurses, academics and new graduates. A mixed methods design was used. Elements included an online survey of nursing students, and interviews with new graduates, Entry to Practice facilitators, ward-based registered nurses, and academics. Descriptive statistics were calculated on quantitative data. Thematic analysis was conducted on qualitative data. Results: Participants included 134 nursing students, five new graduates, seven Entry to Practice facilitators, four registered nurses, and three nurse academics. Students rated facilitators’ effectiveness highly (4.43/5±0.75), although this finding is tempered by a low response rate (13.5%). For learners, the model provided access to learning experiences, although preferences for sources of support differed between students and new graduates, and further clarification of responsibilities was required. For other stakeholders, three themes emerged: students’ and new graduates’ integration into the workplace can promote learning; tensions arise in new ways to approach performance assessment; and aligning expectations requires high levels of communication. Conclusions: This evaluation found that acceptability was good but at risk from limited clarity around roles and responsibilities. Further research into this model is recommended.
Prevalence and risk factors of perceived stress on COVID-19 among health care providers in Dilla Town Health institutions, Southern Ethiopia: A cross-sectional study
Authors: Chekole Yigrem Ali , Yimer Solomon , Mekuriaw Birhanie , Mekonnen Semagn 
Published: April 2020

Abstract
Background: The Coronavirus belongs to large groups of viruses that cause serious health problems including the mental health of the society particularly the health care providers. Understanding the mental health response after a public health emergency might help health care providers and communities to prepare for a population's response to a disaster.Objective: This study aimed to assess the magnitude of perceived stress and risk factors of coronaviruses disease 2019 among healthcare providers in Dilla, Southern Ethiopia 2020.Methods: This cross-sectional study was conducted among 244 samples selected with systematic random sampling technique. Data collection was carried out with validated perceived stress scale adapted from the World health organization. Data were coded and entered into Epi-info Version 7 and was exported and analyzed with SPSS version 20. Crude and adjusted OR were analyzed using logistic regression and the level of significance of association was determined at P-value <0.05.Result: The magnitude of perceived stress of coronavirus disease 2019 among participants was 126 (51.6%). Being at the age range of 25-31 years (AOR=2.5, 95%CI, 1.07, 5.90), nurse professionals (AOR= 7.8, 95%CI 2.15, 27.98) and pharmacist professionals (AOR=4.15, 95%CI, 1.01, 17.06) were variables found to have a strongly statistically significant association with perceived stress of Coronaviruses disease.Conclusion: this indicates that early prevention, early identification and intervention of perceived stress of coronaviruses disease among healthcare providers. Particularly, more stress for the frontline healthcare worker nurses, pharmacists and age ranges of 25-31 years.
Early childhood Group-A streptococcal infections and basal ganglia antibodies in adult ADHD: A preliminary study
Authors: Oliva Francesco , Girolamo Giulia di , Malandrone Francesca , Iaia Noemi , Biasi Fiorella , Maina Giuseppe 
Published: April 2020

Abstract
Background: To explore the relationship between adult Attention Deficit/ Hyperactivity Disorder (ADHD) and recurrent group A streptococcus (GAS) infections during early childhood.Method: Childhood history of recurrent GAS infections and a blood sample were collected in a sample of DSM-IV adult ADHD outpatients. The anti-streptolysin O (ASO), anti-deoxyribonuclease B (anti-DNase B), and anti-basal ganglia antibodies (ABGA) titers were determined in patient plasma by enzyme-linked immunosorbent assay (ELISA). Titers positivity was evaluated following manufacturer's specifications. Absolute titers were also collected as continuous variables.Results: Fourteen out of 22 (63.6%) have had recurrent infections in childhood (i.e., seven, 31.8%, have had tonsillitis or adenoiditis and seven, 31.8%, have had different GAS related infections). Eighteen patients (81.9%) were positive for anti-DNase B, five (22.7%) for ASO, and 4 (18.2%) were positive for both of them. Five participants (22.7%) were ABGA positive, whereas only two (9.1%) were positive for all three antibodies.Conclusions: ADHD patients might be more prone to GAS infections during childhood and seem to have an increased risk for GAS-related autoimmunity in adulthood. Both infections and ensuing acquired autoimmunity could influence the neurodevelopmental process, by contributing, at least in part, to the ADHD pathogenesis.
Melatonin and Vitamin C Attenuate Cassava Diet-Induced Alteration in Thyroid Function
Authors: Alagbonsi Abdullateef , Maliki Oloruntobi Oluwasegun , Ibitoye Comfort Moyinolowa , Olayaki Luqman Aribidesi 
Published: April 2020

Abstract
Background

Cyanide is present in cassava and is well known to cause adverse effects on the male reproductive functions. This study evaluated the effect of melatonin and/or vitamin C on body weight, thyroid function and reproductive parameters in male Wistar rats treated with cyanide-enriched cassava-diet (CD), and their possible mechanisms of actions.
Methods

Forty-five (45) animals were divided into 9 groups (n = 5 each) that received the following treatments for 28 days. Groups I-III received normal saline (control), melatonin (15 mg/kg), and vitamin C (100 mg/kg) only. Groups IV-VI received 40% CD, while groups V and VI were additionally treated with melatonin only and melatonin and vitamin C respectively. Groups VII-IX received 80% CD, but groups VIII and IX were additionally treated with melatonin only and melatonin and vitamin C respectively.
Results

Melatonin and/or vitamin C supplement increased body weight in CD-treated rats. The sperm count (but not other semen parameters) was increased by CD and melatonin, while combination of melatonin and vitamin C in CD-treated rats increased all semen parameters. Neither CD alone nor its co-administration with melatonin and /or vitamin C affected plasma luteinising hormone (LH) and testosterone. The 40% CD and 80% CD increased triiodothyronine (T3), but the increase by the former was abolished by melatonin alone while the increase by the latter was neither affected by melatonin alone nor its combination with vitamin C. Moreover, the 40% CD and 80% CD increased thyroxine (T4), but was neither affected by melatonin alone or its combination with vitamin C. The levels of thyroid stimulating hormone (TSH) were not different across all treatment groups. Both 40% CD and 80% CD increased the thiocyanate level, which was ameliorated by melatonin but abolished by combination of melatonin and vitamin C. Both 40% CD and 80% CD decreased the total antioxidant capacity (TAC) level, which was abolished by melatonin.
Conclusion

In conclusion, this study suggests that CD increases weight gain, thyroid hormone and oxidative stress, which were attenuated by anti-oxidants melatonin and vitamin C.