bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases
Authors: Singh Swati , Pandey Veda P. , Yadav Kusum , Yadav Anurag , Dwivedi U. N. 
Published: September 2020

:
Topoisomerases are reported to resolve the topological problems of DNA during several
cellular processes, such as DNA replication, transcription, recombination, and chromatin remodeling.
Two types of topoisomerases (Topo I and II) accomplish their designated tasks by introducing
single- or double-strand breaks within the duplex DNA molecules, and thus maintain the proper
structural conditions of DNA to release the topological torsions, which is generated by unwinding
of DNA to access coded information, in the course of replication, transcription, and other processes.
Both the topoisomerases have been looked at as crucial targets against various types of cancers
such as lung, melanoma, breast, and prostate cancers. Conceptually, targeting topoisomerases will
disrupt both DNA replication and transcription, thereby leading to inhibition of cell division and
consequently stopping the growth of actively dividing cancerous cells. Since the discovery of camptothecin
(an alkaloid) as an inhibitor of Topo I in 1958, a number of derivatives of camptothecin
were developed as potent inhibitors of Topo I. Two such derivatives of camptothecin, namely,
topotecan and irinotecan, have been commonly used as US Food and Drug Administration (FDA)
approved drugs against Topo I. Similarly, the first Topo II inhibitor, namely, etoposide, an analogue
of podophyllotoxin, was developed in 1966 and got FDA approval as an anti-cancer drug in
1983. Subsequently, several other inhibitors of Topo II, such as doxorubicin, mitoxantrone, and
teniposide, were developed. These drugs have been reported to cause accumulation of cytotoxic
non-reversible DNA double-strand breaks (cleavable complex). Thus, the present review describes
the anticancer potential of plant-derived secondary metabolites belonging to alkaloids, flavonoids
and terpenoids directed against topoisomerases. Furthermore, in view of the recent advances made
in the field of computer-aided drug design, the present review also discusses the use of computational
approaches such as ADMET, molecular docking, molecular dynamics simulation and QSAR to
assess and predict the safety, efficacy, potency and identification of these potent anti-cancerous
therapeutic molecules.
A Heuristic Approach to Crime Prediction based on Generalization of Crime Categories
Authors: Hajela Gaurav , Chawla Meenu , Rasool Akhtar 
Published: September 2020

Background:
As crime rates are increasing all over the world, many methods for crime
prediction based on data mining have been proposed in the past. Crime prediction finds application
in areas like predictive policing, Hotspot evaluation and geographic profiling. It has been observed
in the past that crime is closely related to geographical location, time, weather conditions and day
of the week.

Objective:
Thus, to tackle crime events, a proactive policing approach can be developed using
crime prediction. The main objective of this study is to provide a heuristic approach to crime prediction.

Method:
In this work, a crime prediction approach is proposed which utilizes a crime history dataset
which contains multiple categories of crime. And a heuristic approach based on the generalization
of crime categories is proposed. A spatiotemporal crime prediction technique based on machine
learning techniques is proposed. State-of-the-art classification approaches along with ensemble
learning approach are used for prediction.

Results:
The performance of the proposed model is compared using state-of-the-art classification
techniques without a heuristic approach and with a heuristic approach, and it is found that the model
with heuristics achieves better accuracy.

Conclusion:
Crime events dataset can be utilized to predict future crime events in an area because
crime shows geographical patterns. These spatial patterns might vary with the category of crime
and it is challenging to deal with lots of crime categories. Thus, a generalization based approach
can be a vital asset in crime prediction.
Duality in two west african literary genres: achebe’s a man of the people and soyinka’s the lion and the jewel
Authors: Bazimaziki Gabriel 
Published: September 2020

Literature is a dual discipline as it deals with human beings and their environment at monist and dualist levels. Duality in literature in this respect arouses considerable interest here. It is explored in West African writings with a particular focus on Achebe’s A Man of the People and Soyinka’s The Lion and the Jewel. Both authors’ use of duality for each is examined by attempting to measure the two literary works’ main characters and the leading themes. Achebe’s Chief Nanga and his antagonist, Odili, are compared to Soyinka’s Baroka and his rival Lakunle. Sidi the center of the conflict in Soyinka’s play is measured to Achebe’s Edna. Both writers’ works are examined under the plane of the conflict of generations. The two literary works exhibit the themes of tradition versus modernity depicted through their characters. The analysis revealed that a character in one genre may be different from or similar to another’s story character from a similar or different setting.
Social-agency-embedded Forms of Collective-value Production: Network Modes of Organizing
Authors: Ulhøi John P. 
Published: September 2020

Collective-value production theory is combined with trust theory and the theory of social exchange to explain why network organizations evolve and how they differ in terms of driving forces and key characteristics. The examples are based on field material collected in an egalitarian and team-oriented Scandinavian context. The ability to connect to strategically important clusters of networks is a critical managerial skill. Managers must recognize that the relationships between the different actors in a network are multiplex and dynamic. From a managerial point of view, this also calls for other skills than traditional administrative and managerial skills, e.g. social skills.
Аэродинамический высокопроизводительный распылитель жидких реагентов на основе сопла Лаваля
Authors: Клейманов Р.В. , Александров С.Е. 
Published: September 2020

Авторами статьи предлагается высокопроизводительное устройство для подачи жидкого реагента в установку для химического осаждения высокочистого кварца в пламени. Подача жидкого кремнийсодержащего реагента осуществляется путем преобразования его в аэрозоль при помощи аэродинамического распылителя с плоским соплом Лаваля с внутренним телом. Разработанная конструкция позволяет достичь больших расходов жидкого реагента путем изменения сечений сопла для регулировки скорости газа-распылителя. Предложенная конструкция отличается более высокой технологичностью и простотой изменения расхода реагента в широких пределах, в отличие от распространенных коаксиальных конструкций сопел.

The authors propose a high-performance device for supplying a liquid reagent for the chemical vapor deposition of high-purity quartz. The liquid silicon-containing reagent is supplied by converting it into an aerosol using an aerodynamic nebulizer with a flat Laval nozzle incorporating an internal body. The developed design allows of achieving a high flow rate of the liquid reagent by changing the nozzle cross-sections so as to adjust the speed of the nebulizer gas. The proposed design features higher manufacturability and simple adjustment of the reagent flow rate over a wide range, as distinct from the common coaxial nozzle designs.
Government Social Media Existence: Case Study on the Use of Twitter Regional Disaster Management Agency, Province of Yogyakarta Special Region)
Authors: Juswil Addin Khaerunnisa , Nofrima Sanny 
Published: September 2020

The proper utilization of social media is crucial in terms of disaster management, especially by the government. One of the government’s method to accelerate the dissemination of information regarding disasters is through official government’s twitter account which has proven to be more effective. This study aims to describe the efforts of the Regional Disaster Management Agency (BPBD) of the Special Region of Yogyakarta in handling crisis through a managed twitter account, namely @pusdalops_DIY. This research uses descriptive qualitative research method which is carried out by analyzing the twitter using NVIVO 12 Plus data processing software. The result of this study can be stated that the utilization of the Regional Disaster Management Agency (BPBD) twitter account of the Special Region of Yogyakarta has been effective in disseminating informations and compatible with the main tasks also functions listed in the regional legal basis regarding the Regional Disaster Management Agency (BPBD). However, it still requires further digitalization in all areas of government to be more integrated and communicative in crisis management.
Forceful and Dusty Magnifying Glasses: Violence and Resistance in Bacurau
Authors: Assy Bethania , Chueiri Vera Karam de 
Published: September 2020

This article is on Bacurau, a film by Kleber Mendonça Filho and Juliano Dornelles. It discusses some of its possible references such as Tropicalism movement, Guimarães Rosa’s literature, Glauber Rocha’s New Cinema and Helio Oiticica’s work of art in order to stress the encounter of the primitive and the popular, of technology and mass culture. Despite the radicality of biopolitical and necropolitical dimensions and their unfolding into a kind of necro-capitalism, this article aims at proposing something else concerning the violence infringed by Bacurau's community: first, the idea of literal or immanent violence, mainly by throwing new light into Benjamin’s notion of divine violence; second, moving from immanent violence towards action and resistance. Resistance as an extraordinary and ordinary movement performed individually or collectively by Bacurau’s community. Considering that Bacurau is not just a local community in the Backlands of northeast Brazil but can be any other community in the Globe, we conclude in a non-conclusive manner taking Viveiros de Castro “Indian-becoming” as that which Bacurau encourages us to do.
Quem cala consente: abordagem funcional-construcionista de relativas sem antecedente introduzidas por 'quem'
Authors: Bispo Edvaldo Balduino 
Published: September 2020

Neste trabalho, investigamos o uso da oração relativa sem antecedente introduzida por “quem” em adágios populares, a exemplo de “Quem casa quer casa”, considerando suas formas de organização morfossintática, padrões de estrutura argumental instanciados, aspectos semânticos, cognitivos e interacionais a ela relacionados. O estudo é de caráter quali-quantitativo e fundamenta-se teoricamente na Linguística Funcional Centrada no Uso (FURTADO DA CUNHA; BISPO, 2013) e na Gramática de Construções (GOLDBERG, 2006; TRAUGOTT; TROUSDALE, 2013). O banco de dados desta pesquisa compõe-se de 100 adágios identificados com a ajuda do site de busca Google. Os resultados mostram que a configuração morfossintática das orações que integram os adágios em estudo se relaciona a fatores semânticos (contraponto/jogo de ideias; relação causa-efeito), interacionais (inferência pragmática, inter/subjetividade) e cognitivos (projeções metafóricas e metonímicas).
INTELIGÊNCIA ARTIFICIAL E DIREITOS AUTORAIS: Desafios e Possibilidades no Cenário Jurídico Brasileiro e Internacional
Authors: Felitti da Silva D'ávila Fernanda , Von Hohendorff Raquel , Borghetti Cantali Fernanda 
Published: September 2020

É irrefutável que softwares de inteligência artificial, cada vez mais, produzem conteúdo que antes era apena afeto aos seres humanos. Desde 1970 existem obras artísticas criadas por inteligências artificiais e, inclusive, em formato que é possível considera-las originais e criativas. Tal fato ensejou o enfrentamento teórico sobre a (im)possibilidade de tais obras serem protegidas por direitos autorais. Existem, pelo menos, três correntes teóricas sobre o tema: a primeira atribui direitos autorais diretamente à inteligência artificial, a partir da criação de uma personalidade eletrônica, ou desenvolvendo uma coautoria com a inteligência artificial; a segunda atribui os direitos autorais ao programador do software ou à empresa por trás do investimento, e a terceira defende que não há que se falar em direito autoral neste caso, pertencendo a obra ao domínio público. A discussão do tema enfrenta questões enraizadas sobre a forma de compreensão do mundo pelo ser humano, de grande complexidade, relacionadas a problemas de ordem filosófica, psicológica, social e também jurídica. E é por esta razão que nenhuma das correntes teóricas apresentadas conseguem solucionar de forma plena todos os desafios impostos ao Direito Autoral, já que o cerne para solução do tema proposto é a compreensão da própria inteligência humana e suas limitações. Para a realização da análise teórica, a partir de pesquisa exploratória e bibliográfica, partiu-se de casos concretos, utilizando-se, portanto, do método indutivo para elaboração do trabalho. Palavras-chave: Inteligência artificial. Obras intelectuais. Direito Autoral.
Analisis Pengaruh NPF, BOPO, CAR, FDR dan NIM Terhadap Return on Asset (ROA) Pada Bank Umum Syariah di Indonesia Tahun 2013-2017
Authors: Irawan Dedi , Haryadi  , Puspa Arum Enggar Diah 
Published: September 2020

ABSTRACT
This research aims to determine the effect of NPF, BOPO, CAR, FDR and NIM on Return On Asset (ROA) of Islamic Comercial Banks for year 2013-2017. Data analysis of this research are using descriptive statistics techniques and testing using classic assumption test, multiple regresssion analysis, hypothesis testing and coefisient of determination. the result of the research shows the simultaneously NPF, BOPO, CAR, FDR dan NIM had effect on return on asset (ROA), partially NPF had no effect on return on asset (ROA), BOPO had effect on return on asset (ROA), CAR had effect on the return on asset (ROA), FDR had no effect on the return on asset (ROA) and NIM had effect on return on asset (ROA).
Keywords: Islamic Comercial Banks, Return On Asset (ROA), NPF, BOPO, CAR, FDR, NIM.
ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh NPF, BOPO, CAR, FDR dan NIM terhadap Return On Asset (ROA) Pada Bank Umum Syariah di Indonesia tahun 2013-2017. Analisis data pada penelitian ini menggunakan teknik statistik deskriptif dan pengujiannya menggunakan asumsi klasik, regresi berganda, uji hipotesis dan koefisien determinasi. Hasil penelitian menunjukan bahwa secara simultan NPF, BOPO, CAR, FDR dan NIM berpengaruh terhadap Return On Asset (ROA). Secara parsial NPF tidak berpengaruh terhadap return on asset (ROA), BOPO berpengaruh terhadap return on asset (ROA), CAR berpengaruh terhadap return on asset (ROA), FDR tidak berpengaruh terhadap return on asset (ROA) dan NIM berpengaruh terhadap return on asset (ROA).
Kata kunci: Bank Umum Syariah, Return On Asset (ROA). NPF, BOPO, CAR, FDR, NIM.
Analisis Determinan Pengungkapan Islamic Social Reporting (ISR) di Perusahaan Yang Terdaftar Di Jakarta Islamic Index (JII)
Authors: Abimayu Riman , Mukhzarudfa  , Lubis Tona Aurora 
Published: September 2020

ABSTRACT
The purpose of this research to uncover the practice of supervision on school financial management. The data used in the form of primary to be collected through the questionnaire and in-depth interviews. Respondents and informants of this study were school principals and supervisors. Quantitative and qualitative research methods were used in this study. The results of the research show that supervision at the planning and implementation stage is very good, as evidenced by the involvement of stakeholders in the preparation of school plans, although with different patterns. Supervision at the reporting and accountability stage are still at a good position. The role of supervisor is very needed in supervising school financial management. Supervisory competence regarding financial management must be improved through training, socialization and technical guidance.
Keywords : School , supervision , efficiency and effective

ABSTRAK
Tujuan penelitian ini untuk mengungkap praktik pengawasan pengelolaan keuangan sekolah. Data yang digunakan berupa data primer yang akan dikumpulkan melalui kuesioner dan wawancara mendalam. Responden dan informan penelitian ini adalah kepala sekolah dan pengawas sekolah. Metode penelitian kuantitatif dan kualitatif digunakan pada penelitian ini. Hasil riset menunjukkan pengawasan pada tahap perencanaan dan pelaksanaan sangat baik, terbukti dengan keterlibatan stakeholders dalam penyusunan rencana sekolah, walaupun dengan pola yang berbeda-beda. Pengawasan pada tahap pelaporan dan pertanggungjawaban masih berada pada posisi baik. Peran pengawas sangat dibutuhkan dalam pengawasan pengelolaan keuangan sekolah. Kompetensi pengawas tentang pengelolaan keuangan harus ditingkatkan melalui pelatihan, sosialisasi dan bimbingan teknis.
Kata Kunci : Sekolah, Pengawasan, efisiensi dan efektif.
Analisis Faktor-Faktor yang Mempengaruhi Kinerja Manajerial (Studi Pada Kecamatan Pemekaran di Provinsi Jambi)
Authors: Iqbal Muhammad , Afrizal  , Yudi  
Published: September 2020

ABSTRAK
Penelitian ini bertujuan untuk menganalisis faktor – faktor yang mempengaruhi kinerja manajerial pada Kecamatan Pemekaran di Provinsi Jambi. Sampel yang digunakan sebanyak 73 responden yang merupakan para camat, sekretaris camat, kepala seksi atau kasubag. Teknik pengambilan sampel yaitu sampel jenuh. Jenis data yang digunakan adalah data primer melalui penyebaran kuisioner. Metode analisis data yang digunakan adalah uji instrumen, uji asumsi klasik, uji analisis jalur, uji nilai selisih mutlak dan uji hipotesis. Hasil penelitian menunjukkan bahwa secara simultan partisipasi penyusunan anggaran, kejelasan sasaran anggaran, komitmen organisasi dan gaya kepemimpinan berpengaruh terhadap kinerja manajerial. Secara parsial, komitmen organisasi tidak berpengaruh terhadap kinerja manajerial. Sedangkan partisipasi penyusunan anggaran, kejelasan sasaran anggaran dan gaya kepemimpinan masing-masing berpengaruh terhadap kinerja manajerial. Budaya organisasi hanya memoderasi pengaruh kejelasan sasaran anggaran dan gaya kepemimpinan terhadap kinerja manajerial.
Kata Kunci: Partisipasi Penyusunan Anggaran, Kejelasan Sasaran Anggaran, Komitmen Organisasi, Gaya Kepemimpinan, Budaya Organisasi, Kinerja Manajerial.
Pengaruh Pengungkapan Corporate Social Responsibility dan Profitabilitas Terhadap Nilai Perusahaan Dengan Media Exposure Sebagai Variabel Moderating (Studi Pada Perusahaan Perkebunan yang Terdaftar di Bursa Efek Indonesia, Malaysia dan Singapura Periode
Authors: Sari Meri Novita , Mukhzarudfa  , Yudi  
Published: September 2020

ABSTRAK
Penelitian ini bertujuan untuk mendapatkan bukti empiris tentang (1) Pengaruh Pengungkapan Corporate social responsibility secara parsial terhadap nilai perusahaan perkebunan, (2) pengaruh profitabilitas secara parsial terhadap nilai perusahaan perkebunan, (3) pengaruh pengungkapan Corporate social responsibility dan profitabilitas dimoderasi oleh pengungkapan media secara simultan terhadapnilai perusahaan perkebunandan (4) perbedaan pengaruh pengungkapan Corporate social responsibility dan profitabilitas yang dimoderasi oleh pengungkapan media pada nilai perusahaan perkebunan yang go public di Indonesia, Malaysia, dan Singapura. Jenis penelitian ini yaitu causal explanatory dengan populasi penelitian sebanyak 37 perusahaan.Teknik pengambilan sampel menggunakan teknik purposive sampling. Sampel penelitian ini berjumlah 10 perusahaan. Metode analisis data dilakukan menggunakan regresi sederhana dan regresi berganda dengan MRA. Hasil penelitian menunjukkan bahwa (1) Pengungkapan Corporate social responsibility secara parsial berpengaruh terhadap nilaiperusahaan perkebunan, (2) Profitabilitas secara parsial berpengaruh terhadap nilai perusahaan perkebunan, (3) Pengungkapan Corporate social responsibility dan profitabilitas dimoderasi oleh pengungkapan media berpengaruh secara simultan terhadap nilai perusahaan perkebunan, dan (4) Terdapat perbedaan pengaruh pengungkapan Corporate social responsibility dan profitabilitas yang dimoderasi oleh pengungkapan media pada perusahaan perkebunan yang terdaftar di bursa efek indonesia, malaysia dan singapura. Keterbatasan dalam penelitian ini adalah perbedaan sudut pandang peneliti dalam membaca laporan pengungkapan pertanggungjawaban karena perusahaan memiliki sudut pandang yang berbeda-beda dalam pelaporan.
Kata Kunci : CSR, Profitabilitas, Media Exposure, Nilai perusahaan
Pengaruh Karakteristik Perusahaan Terhadap Nilai Perusahaan Dengan Pengungkapan Sustainability Report Berdasarkan Global Reporting Initiative (GRI) G4 Sebagai Variabel Intervening
Authors: Hikmatia R Tesa , Mukhzarudfa  , Wiralestari  
Published: September 2020

ABSTRAK
Penelitian ini bertujuan umtuk menganalisis pengaruh karakteristik perusahaan yang terdiri dari profitabilitas, leverage, likuiditas dan ukuran perusahaan terhadap nilai perusahaan dengan pengungkapan sustainability report berdasarkan Global Reporting Initiative (GRI) G4 sebagai variabel intervening. Populasi dari penelitian ini adalah perusahaan sektor non-keuangan yang terdaftar di Bursa Efek Indonesia (BEI). Pemilihan sampel ini menggunakan metode purposive sampling, dengan kriteria perusahaan yang menerbitkan sustainability report terpisah dari laporan tahunan pada tahun 2013-2017. Pengujian hipotesis menggunakan analisis partial least square (PLS) dengan prosedur statistik menggunakan software SmartPLS 3.0. Hasil penelitian menunjukkan bahwa profitabilitas, leverage, likuiditas dan ukuran perusahaan tidak berpengaruh terhadap pengungkapan sustainability report. Profitabilitas, likuiditas, ukuran perusahaan dan pengungkapan sustainability report berpengaruh signifikan terhadap nilai perusahaan. Sedangkan leverage tidak berpengaruh terhadap nilai perusahaan. Pengungkapan sustainability report sebagai variabel intervening tidak memberikan pengaruh pada profitabilitas, leverage¸ likuiditas dan ukuran perusahaan terhadap nilai perusahaan. Pengungkapan sustainability report tidak dapat memediasi hubungan antara karakteristik perusahaan terhadap nilai perusahaan.
Kata kunci: Karakteristik Perusahaan, Nilai Perusahaan, Pengungkapan Sustainability Report