bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrological Functioning of Forested Catchments, Central Himalayan Region, India.
Authors: Qazi Nuzhat Ul Qayoom 
Published: June 2020

Abstract
Background: Central Himalayan forested catchments provide fresh water supply and innumerable ecosystem services to millions of people. Hence, the understanding of linkages between forests and water is very crucial to recognize for availability and quality of water at catchment scale. Therefore, present study aims to understand hydrological response of two forested catchments (namely, Arnigad and Bansigad) in the Central Himalayan Region.Methods: Three-year data (March, 2008 to February, 2011) were collected from meteorological and hydrological stations installed at Arnigad and Bansigad catchments. The present paper displays mean hydrological response of forested catchments through detailed field investigation.Results : The annual hyetograph analysis revealed that the rainfall at both the catchments was highly seasonal, and wet-period (June-September) plays a key role in catchment functioning. Exceedance of rainfall threshold of ~200 mm (~10% of annual rainfall) significantly increased streamflow generation at both the catchments. At Arnigad, stream was perennial with a mean baseflow of ~83 mm per month (~ 6 % of annual baseflow) whereas, Bansigad had greater seasonality due to lack of streamflow during the pre-wet-period (March-May). Separation of hydrographs at Arnigad and Bansigad catchments i.e. stormflow (6% and 31%, respectively) and baseflow (50% and 32%, respectively) helped to understand the probability of flooding during wet-period and drought during dry-period. Forest ecosystem at Arnigad improved the hydrological functioning by: reducing stormflow (82%), and enhancing: baseflow (52%), soil moisture (13%), steady infiltration rate (22%) and lag time (~15 minutes) relative to Bansigad. These enhanced values indicated soil capability to store water at forested catchment (Arnigad) and helped to understand the volume of water (discharge) that was available during dry-period. The decrease of denudation rate (at Arnigad) by 41% resulted decrease in suspended sediment (18%) and bed load (75%) compared to Bansigad. Further, the enhancement of dissolved solids in stream resulted due to maximum organic matter generated in forest floor of Arnigad. Conclusion: This study accomplishes that rainfall during the wet-period was the main driver of hydrological functioning, whereas, forests provided substantial services by regulating water balance, soil moisture and sediment budget at Arnigad catchments through different mechanisms of forest components at catchment-scale in the Central Himalayan region.
The Effect of Social Norm-based Intervention with Observable Behaviour on Physical Activity among Adolescents: A Randomized Controlled Trial
Authors: Lee Jia Jia , Nadkarni Nivedita Vikas , Teo Irene , Ozdemir Semra 
Published: June 2020

Abstract
Background: To evaluate the effectiveness of providing descriptive norms messages with personal identification in promoting physical activity among adolescents by measuring step counts via a randomized controlled trial (NCT03081013). Methods: A total of 311 participants aged 13-16 were randomized into two study arms (Onymous and Anonymous Arms). Each arm consisted of 13 groups of 12 participants. During the trial, participants received weekly short message service (SMS) about their past week’s physical activity performance Participants in the Anonymous Arm received information about step counts of group members ranked from highest to lowest. Participants in the Onymous Arm received the same information with the group members’ full names. Participants’ quality of life, depression, and physical activity social support, self-efficacy and enjoyment before and after the intervention were also evaluated. This study adheres to the CONSORT guidelines. Results: The number of steps was not higher when descriptive norm message was onymous compared to when it was anonymous. Scores in quality of life, depression, social support, self-efficacy, and enjoyment of physical activity were not significantly different between both arms (p>0.05). Conclusions: Our findings indicated that the effect of providing descriptive norms messages containing personal identification on physical activity promotion was not evident in the main analysis.
Psychometric properties of the Chinese version of the aging transformation scale for elderly dementia patients
Authors: li you lai , yu bo li , sun ning , dong xin xiao , ying chen yu , lang jun han , zhou heng li 
Published: June 2020

Abstract
Background: The key part of home care services is the assessment of the needs of the home environment for elderly patients with dementia. The present study was conducted to evaluate the psychometric properties of a newly adapted Chinese version of an instrument designed to measure aging transformation needs among elderly patients with dementia.

Methods: A sample of 175 patients with elderly dementia was selected from ten communities in China. The 55-item aging transformation needs scale was answered by the participants. Content validity, Cronbach’s alpha, item-to-total correlation, and exploratory factor analysis were used to assess the reliability and validity of the instrument.

Results: The aging transformation needs scale has a good surface validity, content validity, and structural validity. The content validity was 0.965; 55 items had large factor loads on their corresponding principal components (≥0.5). There was a significant correlation between the aging transformation needs scale and each component (r = 0.897-0.973, all P<0.01), and 9 components also had a high correlation (r = 765～0.977, all P<0.01); the total table Cronbach's α was 0.993, the Cronbach's α of each constituent factor was 0.944～0.990, and the correlation coefficient between factor and content was >0.40 (all P<0.01).

Conclusions: Evidence was found to support the reliability and validity of the aging transformation needs scale that measures the quality of the aging transformation needs for patients with elderly dementia from an aging transformation needs perspective.
Long non-coding RNA CASC15 promotes HCC progression via modulation of Six1 targeted by miR-2355-5p
Authors: Hong Han , Sui Chengjun , Qian Tao , Xu Xiaoyong , Zhu Xiang , Fei Qiang , Yang Jiamei , Xu Minhui 
Published: June 2020

Abstract
Background: Long-chain non-coding RNA (LncRNA) plays a key role in the biological processes of tumors. LncRNA CASC15 has been shown to be involved in the development of a variety of tumors. The study aimed to elucidate the mechanism of lncRNA CASC15 in the progression of hepatocellular carcinomas (HCC).Methods: qRT-PCR was used to detect the expression levels of CASC15, miR-2355-5p and Six1 mRNA in HCC tissues and cells. Six1 protein expression levels were detected by Western Blot. CCK-8 experiment, colony formation experiment, Edu staining and Transwell experiment analysis were used to analyze the effects of CASC15, miR-2355-5p and Six1 on cell proliferation, cell invasion and migration. The relationship between CASC15, miR-2355-5p and Six1 was analyzed using bioinformatics analysis and Luciferase.Result: CASC15 was raised in HCC tissues and HCC cells. Down-regulation of CASC15 inhibited the growth, migration, invasion and tumor growth of HCC cells. The expression level of miR-2355-5p was reduced in HCC tissues. In addition, miR-2355-5p inhibitor induced the growth, migration and invasion of HCC cells. MiR-2355-5p was predicted to be a downstream target of CASC15. The expression level of miR-2355-5p was negatively correlated with CASC15 in HCC tumor tissues. Six1 was predicted to be a downstream target of miR-30a-5p. In vitro and in vivo results showed that CASC15/miR-2355-5p can regulate Six1.Conclusion: LncCASC15 regulated the proliferation and invasion of Six1 by binding with miR-2355-5p in HCC, suggesting that CASC15 may be a potential target for HCC.
Development of a Survival Model Based on Autophagy-Associated Genes for Predicting Prognosis of Gastric Cancer
Authors: Yang Wanli , Duan Lili , Zhao Xinhui , Niu Liaoran , Li Yiding , Wang Xiaoqian , Zhang Yujie , Zhou Wei , Liu Jinqiang , Zhao Qingchuan , Han Yu , Fan Daiming , Hong Liu 
Published: June 2020

Abstract
Background: Gastric cancer (GC) is one of lethal diseases worldwide. Autophagy-associated genes play a crucial role in the cellular processes of GC. Our study aimed to investigate and identify the prognostic potential of autophagy-associated genes signature in GC. Methods: RNA-seq and clinical information of GC and normal controls were downloaded from The Cancer Genome Atlas (TCGA) database. Then, the Wilcoxon signed-rank test was used to pick out the differentially expressed autophagy-associated genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to investigate the potential roles and mechanisms of autophagy-associated genes in GC. Cox proportional hazard regression analysis and Lasso regression analysis were carried out to identify the overall survival (OS) related autophagy-associated genes, which were then collected to construct a predictive model. Kaplan-Meier method and receiver operating characteristic (ROC) curve were utilized to validate the accuracy of this model. Finally, a clinical nomogram was established by combining the clinical factors and autophagy-associated genes signature. Results: A total of 28 differentially expressed autophagy-associated genes were identified. GO and KEGG analyses revealed that several important cellular processes and signaling pathways were correlated with these genes. Through Cox regression and Lasso regression analyses, we identified 4 OS-related autophagy-associated genes (GRID2, ATG4D, GABARAPL2, and CXCR4) and constructed a prognosis prediction model. GC Patients with high-risk had a worse OS than those in low-risk group (5-year OS, 27.7% vs 38.3%; P=9.524e-07). The area under the ROC curve (AUC) of the prediction model was 0.67. The nomogram was demonstrated to perform better for predicting 3-year and 5-year survival possibility for GC patients with a concordance index (C-index) of 0.70 (95% CI: 0.65-0.72). The calibration curves also presented good concordance between nomogram-predicted survival and actual survival. Conclusions: We constructed and evaluated a survival model based on the autophagy-associated genes for GC patients, which may improve the prognosis prediction in GC.
The effects of navigation and tranexamic acid in reducing the need for blood transfusion after TKA
Authors: Song Suk Kyoon , Kim Hee Chan , Chae Seung Bum , choi wonkee 
Published: June 2020

Abstract
Background:

We investigate the synergistic effect of the use of tranexamic acid and navigation in reducing the need for blood transfusion after total knee arthroplasty (TKA). Secondly, we compare the effects of navigation and tranexamic acid on blood transfusion reduction after TKA.
Methods:

Patients were divided into 3 groups and compared. Those who had manual TKA with the use of tranexamic acid were group 1 (N = 30), those who had navigated TKA without tranexamic acid were group 2 (N = 30), and those who had navigated TKA with tranexamic acid were group 3 (N = 30). Group 1 was studied prospectively, while group 2 and 3 were studied retrospectively. All operation was held by one operator. We measured the frequency of transfusion after the operation within the admission period. To compare the postoperative bleeding, drainage volume during two days after surgery was compared and analyzed.
Results:

Group 1 (Manual TKA with tranexamic acid) had 2 cases of transfusion (6.7%), while there were 9 cases in group 2 (Navigated TKA with no tranexamic acid) (30%), and 3 cases in group 3 (Navigated TKA with tranexamic acid) (10%). In Chi-square test, this difference was statistically significant. Average of 525.50 ± 194.91 ml of drainage was drained in two days after surgery in group 1 (Manual TKA with tranexamic acid), 611.60 ± 263.20 ml in group 2 (Navigated TKA with no tranexamic acid) and 411.42 ± 188.21 ml in group 3 (Navigated TKA with tranexamic acid). This difference was analyzed in one-way ANOVA which showed significantly different. The need for transfusion in group 2 (Navigated TKA with no tranexamic acid) was 5.86 times higher than that in group 1 (Manual TKA with tranexamic acid). The necessity of transfusion in the group 3 (Navigated TKA with tranexamic acid) was 0.199 times higher than that of the group 2 (Navigated TKA with no tranexamic acid).
Conclusion:

The combined use of navigation and tranexamic acid has no synergistic effect in reducing post TKA bleeding and the need for blood transfusion compared to tranexamic acid alone. And, use of tranexamic acid is more effective than navigation in reducing blood transfusions and blood loss after TKA.
Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction
Authors: yongan Jiang , yu Liu Jia , Dongdong Li , Wangwang Hong , ru'en Liu 
Published: June 2020

Abstract
In the synthesis of chemical drugs used to treat various cancers and tumors,more and more scientists are now focusing on the development of natural extracts.Paeoniflorin,as an important compounds of the total glucosides of peony,,had therapeutic effects on a variety of cancers in vivo and in vitro experiments.The purpose of this study was to use biological information analysis to reveal the basic mechanism and potential molecular mechanism of paeoniflorin treatment.We evaluated the efficacy of paeoniflorin through Traditional Chinese Medicine Systems Pharmacology Database(TCMSP).The potential targets of paeoniflorin were identified and summarized by Comparative Toxicogenomics Database (CTD),and GeneMANIA protein interaction analysis was performed online.Also.We used WebGestalt for Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis and functional annotation.Finally,cytoscape was used to construct the paeoniflorin-target-pathway network to predict the results.
Investigating the Effective Factors on Implementation of World Health Organization Package of Essential Non communicable Disease Interventions for Primary Health Care in Low Resource Settings: A Scoping review
Authors: Aminpour Mina , Aryankhesal Aidin , Seyfori Nasrin 
Published: June 2020

Abstract
Background/objective:

Due to the widespread prevalence of non-communicable diseases, the World Health Organization has designed a package of essential interventions for non-communicable diseases for primary health care in low-resource settings. This study aimed to investigate the factors affecting the implementation of the WHO PEN for primary health care in low-resource settings.
Materials and Methods

This research was conducted through a five-step process of scoping review. We first searched for the keywords Noncommunicable Diseases, NCD, WHO PEN, PEN and other synonyms for these words to find the suitable analytical studies in databases including PubMed / MEDLINE, Scopus Cochrane Library, Web of Science, Google Scholar. The articles were then selected based on the PRISMA 2009 Flow Diagram. Finally, to analyze the content from the results section of the selected articles, we used the framework analysis method to extract the study implementation outcome and the factors affecting it.
Results

A total of 26 articles were included. Most articles are from 2016 to 2018. Most of the articles were cross-sectional and most studies evaluated the outcomes of Appropriateness and Feasibility. Identified effective factors include target population coverage, staff training, patient motivation, patient follow-up, and observance of PEN protocols.
Conclusion

Using this study, policymakers and managers of the health system will be able to implement this package (WHO PEN) more successfully.
Assessment of Vestibular and Oculomotor Function in Patients with Vestibular Migraine: A Preliminary Study
Authors: Fu Wei , Han Junliang , He Feng , Bai Ya , Wei Dong , Chang Ning , Shi Ying , Wang Yuanyuan 
Published: June 2020

Abstract
Background: The purpose of the study is to assess the vestibular and oculomotor function in patients with vestibular migraine(VM).And we also investigate the relationship between test resultsandeffectiveness of prophylactic medication.Methods: We recruited 41 patientswith VM. They were examinedwith vestibular-evoked myogenic potentials(VEMP), video head impulse test(vHIT) and videonystagmography(VNG), including spontaneous or positional nystagmus, gaze-evoked nystagmus, smooth pursuit and caloric irrigation testing.All VM patients were treated withprophylactic medications. Theintensity of vertigo were evaluated with dizziness handicap inventory(DHI) before and after treatment. After 6 months, we evaluate the effectiveness of prophylactic medication. We analyzed the relationship between test resultsandeffectiveness of prophylactic medication.Results:In vestibular function test,71% of VM patients showed abnormal result. 20% showed abnormal air-conducted cVEMP and 42% showed abnormal air-conducted oVEMP. 32% showed abnormal vHIT and 56% showed abnormal caloric irrigation test.The abnormal rate of oVEMP was significantly higher than cVEMP (p<0.05). And the abnormal rate of caloric irrigation test was significantly higher than vHIT(p<0.05). In oculomotor function test, 42% showed pathological result. The abnormal rate of oculomotor function test was significantly lower than vestibular function test (p<0.05). After 6 months follow-up, rate of good effectiveness was significantly higher in normal vestibular function test group compared with the abnormal vestibular function test group (p<0.05). Rate of good effectiveness was no statistically significant difference between normal oculomotor function test group and abnormal oculomotor function test group (p>0.05).Conclusions: Abnormal vestibular and oculomotor function are commonly observed in VM patients. And VM patients with abnormal vestibular function have a weak effectiveness of prophylaxis medications.
Perinatal morbidity and mortality and the impact of neonatal resuscitation day-by-day calamity evidenced by a prospective descriptive study in Guinea-Conakry
Authors: DIALLO Abdourahamane , DIALLO Ibrahima Sory , BAH Ibrahima Koussy , DIALLO Mamadou Cellou , DESSEAUVE David , SY Telly , ROTH-KLEINER Matthias 
Published: June 2020

Abstract
Background

Perinatal mortality represents a major health care problem in particular in low and middle-income countries, which account for 97% of all late fetal and 98% of all neonatal deaths. Our objectif was to analyse perinatal morbidity and mortality at the largest maternity clinic of Guinea, in sub-Saharan Africa.
Patients & Methods:

Prospective observational evaluation of the perinatal morbidity and mortality between May 1st and June 30th 2019 at the Clinic of Obstetrics of the University Hospital Ignace Deen in Conakry, Guinea.
Results

Of the 1189 deliveries, 98 (82‰) fetus were born dead, 58.1% of them with signs of maceration. 14.1% of all infants had low birth weight (< 2500 g) and 10.6% were macrosome (> 4000 g). The rate of preterm infants was 9.3% and 99 infants (8.3%) showed signs of post-maturity. At birth, 6.8% of all live born infants had asphyxia, 10.9% respiratory distress, 1.9% infection, 0.3% malformation, and nine infants died within the first postnatal minutes. Need for any resuscitation manoeuvres showed 304 infants (27.9%), 68.8% of them needed bag and mask ventilation and 27.0% chest compressions. Infants with bad Apgar score at 1 and 5 minutes did improve by 10 minutes thanks to respiratory support, but not due to chest compression. As there is no neonatal unit in the same hospital, 192 infants (17.6%) had to be transferred across Conakry to the only tertiary neonatal unit. Due to lack of any (para-)medical transport system for newborn infants, mortality of these neonates is very high and adds to the total perinatal mortality of 143.8 deaths/1000 deliveries.
Conclusions

Late pregnancy control is very poor in Conakry, leading to delayed referral of high-risk pregnancies to the university hospital. This goes along with high rates of stillbirths, post-term and macrosome infants with increased risk for delivery complications like postnatal adaptation problems and asphyxia. Resuscitation algorithm needs to be adapted to the local context. A hospital-based neonatal unit for primary stabilization and a medicalised neonatal transport system within Conakry needs to be implemented to decrease the high mortality rate.
Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study)
Authors: liu huan , Liu Jinbo , Huang Wei , Zhao Hongwei , zhao Na , wang Hongyu 
Published: June 2020

Abstract
Background Arteriosclerosis can be reflected in various aspect of the artery, including atherosclerotic plaque formation or stiffening on the arterial wall. Both arteriosclerosis and atherosclerosis are important and closely associated with cardiovascular disease (CVD). The aim of the study was to evaluate the association between systemic arteriosclerosis and multi-site atherosclerotic plaques. Methods The study was designed as an observational cross-sectional study. A total of 1178 participants (mean age 67.4 years; 52.2% male) enrolled into the observational study from 2010 to 2017. Systemic arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and multi-site atherosclerotic plaques (MAP, >=2 of the below sites) were reflected in the carotid or subclavian artery, abdominal aorta and lower extremities arteries using ultrasound equipment. The associations were assessed by multivariable logistic regression. Results The prevalence of CF-PWV >12 m/s and MAP were 40.2% and 74.4%. Atherosclerotic plaques in 3 sites were more common in male compared with that in female (48.9% versus 36.9%, p<0.05). All CVD factors were worse in participants with MAP than that with <=1 site. Participants with CF-PWV>12m/s corresponded to a mean 82% probability of MAP with age and sex-adjusted. Patients with peripheral artery disease showed the highest odds ratio (OR) (3.88) for MAP, followed by smoking (2.485), CF-PWV>12m/s (2.25), dyslipidemia (1.89), male (1.84), stroke (1.64), hypoglycemic agents (1.56) and age (1.09) (all p<0.001). Conclusions MAP was highly prevalent in this cohort, with male showing a higher prevalence than female. Higher systemic arteriosclerosis was independently associated with MAP, which indicating the supplementary value of arteriosclerosis for the earlier identification and intervention on MAP.