bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of curcumin and its nanomicelle form on body weight, insulin resistance, adiponectin, and blood parameters of streptozotocin-induced diabetic rats
Authors: Dadgar Hamed , Kermanshahi Hassan , Jaafari Mahmoud Reza , Javadmanesh Ali 
Published: January 2021

Abstract
Curcumin can be used for diabetes treatment. However, it rapidly degrades and has low absorption in gastrointestinal system. Its nanomicelle form might improve its efficiency. Therefore, they both assessed in streptozotocin-induced diabetic rats. Fifty male wistar rats were induced diabetes and divided into 5 groups and treated with 1) no dietary supplement, 2 and 3) 40 and 80 mg/kg curcumin, 4 and 5) 40 and 80 mg/kg nanomicelle curcumin. A group of 10 untreated rats was considered as healthy control. Serum concentrations of AST, ALT, glucose, insulin, insulin resistance, triglycerides, cholesterol, HDL-C, LDL-C and adiponectin were assessed. Body weight and weights of liver, heart and pancreas were also evaluated. Induction of diabetes increased the serum concentrations of AST, ALT, glucose, triglycerides, cholesterol, LDL-C and insulin resistance and decreased the serum concentrations of insulin, adiponectin, and HDL-C, and also body weight and weights of heart and pancreas (P<0.05). Nanomicelle form of curcumin alleviated the negative effects of diabetic rats for glucose, lipid profile, and liver enzymes (P<0.05). In conclusion, nanomicelle form of curcumin showed better efficiency for alleviating the adverse effects of diabetes. It can be suggested that nanomicelle form of curcumin at specific doses can be used for diabetes treatment.
Efficacy of Acupuncture in Improving Symptoms and Quality of Life of Patients With Acne Vulgaris: a Randomized Sham Acupuncture-controlled Trial
Authors: Jiao Ruimin , Zhai Xu , Zhang Xuecheng , Xiong Zhiyi , Liu Zhishun 
Published: January 2021

Abstract
Objective: The aim of this study was to examine the effectiveness of acupuncture in treating the symptoms and QoL of patients with moderate or severe AV. Methods: Participants were randomly assigned (1:1) to receive 12 treatment sessions of acupuncture or sham acupuncture over 4 weeks with 24 weeks of follow-up. The primary outcome was the change from baseline in the Skindex-16 scale total score at treatment completion. Secondary outcomes included Skindex-16 subscale score, Dermatology Life Quality Index scale total score, total lesion count and inflammatory lesion count, and visual analogue scale scores for itch and pain evaluation. Results: There is no statistically significant between-group difference for the primary outcome and any secondary outcomes after 4 weeks of treatment and at 16 weeks and 28 weeks of follow-up, except for the Skindex-16 subscale (the emotions of participants with AV) at week 4 (P = 0.026). No serious adverse events occurred in two group. Conclusion: Acupuncture and sham acupuncture might both relieve the symptoms of patients with moderate or severe AV, reduce the number and degree of inflammatory lesion counts, and improve QoL. Trial registration number: ChiCTR-1900023649 Chinese Clinical Trial Registry
Genomic insight into diet adaptation in the biological control agent Cryptolaemus montrouzieri
Authors: Li Hao-Sen , Huang Yu-Hao , Chen Mei-Lan , Ren Zhan , Qiu Bo-Yuan , De Clercq Patrick , Heckel Gerald , Pang Hong 
Published: January 2021

Abstract
Background
The ladybird beetle Cryptolaemus montrouzieri Mulsant (Coleoptera, Coccinellidae) is used worldwide as a biological control agent. It is a predator of various mealybug pests, but it also feeds on alternative prey and can be reared on artificial diets. Relatively little is known about the underlying genetic adaptations of its feeding habits.
Results
We report the first high-quality genome sequence for C. montrouzieri. We found that the gene families encoding chemosensors and digestive and detoxifying enzymes among others were significantly expanded or contracted in this ladybird in comparison to other beetles. Diet-specific larval transcriptome profiling demonstrated that differentially expressed genes on unnatural diet as compared to natural prey were enriched in pathways of nutrient metabolism, indicating that the lower performance on the tested diets was caused by nutritional deficiencies. Remarkably, the C. montrouzieri genome also showed a significant expansion in an immune effector gene family. Some of the immune effector genes were dramatically downregulated when larvae were fed unnatural diets.
Conclusion
We suggest that the evolution of genes related to chemosensing, digestion, and detoxification but also immunity might be associated with diet adaptation of an insect predator. These findings help explain why this predatory ladybird has become a successful biological control agent and will enable the optimization of its mass rearing and use in biological control programs.
Improvement of Outcomes in Hemodynamically Unstable Patients With Pelvic Fracture Following The Establishment of a Trauma Center: A Single Center Observational Study in Korea
Authors: Lee Mina , Yu Byungchul , Lee Giljae , Lee Jungnam , Choi Kangkook , Park Youngeun , Gwak Jihun 
Published: January 2021

Abstract
Background: The trauma center and multidisciplinary management protocols have been proved to improve the outcomes of severely injured patients. Hemorrhage from pelvic injury is associated with high mortality and is a common cause of preventable trauma death. This study aims to evaluate the effects of the establishment of a trauma center and management protocols on the outcomes of hemodynamically unstable patients with pelvic fractures.Methods: Hemodynamically unstable patients with pelvic fractures were reviewed retrospectively over a 10-year period. They were grouped into periods 1 and 2, which were defined as before and after the establishment of a trauma center and protocols, respectively. Basic characteristics and outcomes were compared between periods.Results: This study enrolled a total of 106 patients. Basic and physiological characteristics were not significantly different in both periods. Pre-peritoneal packing (PPP) and resuscitative endovascular balloon occlusion of aorta (REBOA) were only performed in period 2 (PPP, N = 27; REBOA, N = 10). In period 2, the time from emergency room arrival to hemostatic intervention was significantly shorter (269 ± 132.4 min. vs. 147.2 ± 95.5 min., p < 0.0001), and mortality due to acute hemorrhage was significantly decreased (33.3% vs. 8.6%, p = 0.018). The multivariate logistic regression analysis identified age, ISS, and period 1 as independent risk factors for mortality.Conclusion: The establishment of a trauma center and multidisciplinary management protocols, such as PPP and REBOA, improved the outcomes of hemodynamically unstable patients with pelvic fractures.
Knowledge, attitudes, and practices towards COVID-19 pandemic among residents of Jharkhand state, India: An online survey
Authors: Rai Arpita , Nishant Nishant , Singh DK , Kulkarni Nitin Madan , Chaurasia Shailesh Kumar , Pathak LR 
Published: January 2021

Abstract
Background
People's adherence to control measures is imperative in the fight against COVID-19. The present study was done to evaluate knowledge, attitudes, and practices towards COVID-19 among residents of Jharkhand and to assist government in deciding further course of action during the COVID-19 outbreak.
Methods
This study was an online cross sectional survey. The link to the questionnaire was displayed on the official website of Rajendra Institute of Medical Sciences, Ranchi, Government of Jharkhand, National Health Mission, Jharkhand, official website of all districts under Jharkhand state administration, Integrated Disease Surveillance Programme and Information & Public Relations department. Participation of residents in the survey was also extensively propagated using mass media mainly local television networks, radio channel and newspapers.
Results
A total of 4683 responses were received from all districts of Jharkhand. Majority of the participants were young adults (47.5%) and number of male participants was more than the females (81.4%). Mean correct knowledge score for participants of this study was 10.73 + 2.2 (maximum attainable score was 14) while mean practice score for the participants was 4.5 + 0.69 (maximum attainable score was 5). Knowledge score of the participants was significantly associated with their age, education status and economic class (p < 0.05). The participants largely held an optimistic attitude and healthy practices towards COVID-19.
Conclusions
Participants had positive attitude but were also logically worried and uncertain about near future. Adequate knowledge of participants was visible in the practices of residents. There was however a gap across age groups, gender, literacy and income levels which should be addressed in future campaigns.
Trichinella in Wildlife in Chile With the First Record in Leopardus Guigna and Galictis Cuja
Authors: Echeverry Diana Maritza , Henríquez AnaLía , González-Acuña Daniel , Fuente Carolina Silva-de la , Ortega René , Sandoval Daniel , Landaeta-Aqueveque Carlos 
Published: January 2021

Abstract
Background: Trichinellosis is a worldwide distributed disease caused by Trichinella species and also considered neglected and emerging. Trichinella spp. are transmitted by predation or carrion consumption and present a domestic and a sylvatic cycle. Human trichinellosis occurs due to the consumption of raw or poorly cooked infected meat, mainly associated with the household slaughter of pigs without veterinary inspection, a cultural practice that is difficult to resolve. Therefore, the knowledge of the reservoir of this parasite is relevant. Methods: The aim of this study was to assess the presence of Trichinella sp. in several carnivore and omnivore vertebrates in Central-Southern Chile. A total of 61 animals, either found run over or that died in rescue/rehabilitation centers, encompassing 15 species, were examined by artificial digestion for detection of Trichinella larvae, and larvae were molecularly analyzed to identify the species. Results: Trichinella larvae were found in a Leopardus guigna and a Galictis cuja. Only those of L. guigna could be identified as Trichinella spiralis. Conclusions: This is the first record of Trichinella in a native mustelid of South America and the first record of T. spiralis in L. guigna. These results increase the number of hosts, enhancing the need to identify the role of these animals in the reservoir for humans, and highlighting the priority that the study of the rural-sylvatic interphase represents.
ACSL3 As a Potential Prognostic Biomarker in Patients With Breast Cancer
Authors: Sun Xiangyu , Li Meng , Wang Mozhi , Wang Mengshen , Dong Haoran , Yao Litong , Li Xinyan , Wang Yusong , Tan Shirong , Chen Yuhai , Xu Yingying 
Published: January 2021

Abstract
Objective: To explore the expression pattern of long chain fatty acyl CoA synthetase 3 (ACSL3) in breast cancer, and evaluate the clinical significance of ACSL3 by analyzing potential function and prognostic value of ACSL3 in human breast carcinoma.Methods: The expression of ACSL3 in normal mammary tissues and breast tumor tissues was analyzed by GEPIA and Human Protein Atlas. The prognostic value of ACSL3 was evaluated by Kaplan–Meier plotter analysis. ACSL3 expression was analyzed by immunohistochemistry in 297 breast cancer patients from the First Hospital of China Medical University Furthermore, based on LinkedOmics database, analyses of GO and KEGG pathways were performed to identify the potential function of ACSL3. Tumor Immune Estimation Resource (TIMER) database was used to evaluate the association between ACSL3 and immune infiltration in breast cancer. Results: GEPIA and Human Protein Atlas indicated that ACSL3 was significantly upregulated in breast carcinomas. Kaplan-Meier plotter analysis showed that increased expression of ACSL3 mRNA was significantly associated with shorter overall survival (OS) and relapse-free survival (RFS) in breast cancer patients. Results from immunochemical staining showed that ACSL3 was obviously related to clinicopathological features of breast cancer, and ACSL3 was highly abundant in TNBC tumors. Moreover, survival analysis of breast cancer patients demonstrated that higher ACSL3 protein expression is unfavorable prognostic biomarker in breast cancer patients. Results from TIMER database indicated that ACSL3 expression was significantly correlated with infiltration level of multiple immune cells. Further studies are needed to explore underlying mechanism of the pro-tumor effects of ACSL3 expression.Conclusions: ACSL3 may not only serve as a reliable predictive biomarker of breast cancer but also have impact on the occurrence and progression of breast cancer. Thus, ACSL3 may be an emerging therapeutic target for the development of molecular-targeted therapeutic strategies for breast cancer.
Maternal stress and depressive symptoms and adolescents’ body mass index: A prospective study.
Authors: Koning Maaike , Vink Jacqueline , Visscher Tommy L.S. , Larsen Junilla 
Published: January 2021

Abstract
Background Growing evidence suggests that maternal mental health issues are associated with (young) children’s weight outcomes. However, most studies have been limited by cross-sectional designs and have been aimed at (younger) children. The current prospective study focuses on the link between maternal mental health (i.e., psychological stress and depressive symptoms) and adolescents’ zBMI development.Methods The participants in the present study were part of wave 1 and 2 of a longitudinal study on Dutch adolescents’ and their parents’ health behavior. Adolescents (aged 10-14) and their parents were recruited through six secondary schools in the South and the East of the Netherlands. For this study, we only included biological mothers and their adolescent children who participated in both waves, with data on the main measures on both waves, leaving a final sample of 336 biological mother child dyads. Adolescents height and weight were measured, and both parents and adolescents filled in validated questionnaires on perceived stress and depressive symptoms and answered additional questions concerning domain-specific stress. Regression analyses were performed in R to examine longitudinal links between maternal stress and depressive symptoms at baseline (T1) and adolescents’ BMI standard deviation scores (zBMI) 6 months later (T2), corrected for baseline zBMI and covariates. Results Maternal general perceived stress (b=.20, p =.002) at T1 preceded higher adolescents’ zBMI at T2, after controlling for baseline zBMI and other covariates, whereas maternal depressive symptoms at T1 (b=-.05, p =.44) and other domain-specific stress did not (maternal financial stress, maternal stress at work, maternal stress at home). Additionally, lower educational level among adolescents (b = .16, p = .001) and adolescent depressive symptoms (b = .16, p = .001) was associated with a higher zBMI at T2. Conclusions Results suggest that maternal general stress, but not depressive symptoms, may influence adolescents’ weight development. Our findings warrant future investigation on whether and how general stress among mothers may predict weight increases of their adolescent offspring.
Assessment on awareness towards preventive measures of COVID-19 in Sheka, Ethiopia: Community based cross-sectional Study
Authors: Gelaw Assaye Belay , Andargie Solomon Abebaw 
Published: January 2021

Abstract
Background: The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and it is the most important of public health problem worldwide. A critical element in tackling the COVID-19 crisis is personal behavioral change; however, there is a paucity of evidence about peoples’ awareness towards COVID-19 pandemic. Hence, this study was aimed to assess the people’s awareness status towards COVID-19 in Sheka, Southwestern Ethiopia.Methods: Community-based cross-sectional study was conducted between 10th to 21th April 2020. Four hundred-nineteen individuals participated during the study. Both univariable and multivariable logistic regression analyses were used to identify significant factors of awareness status, and variables with p-value<0.05 indicated it significantly influences the awareness status of the individuals towards COVID-19.Results: According to the study’s results, nearly half (49.4 %) of the participants had awareness about COVID-19 pandemic. Factors such as sex, education level, religion, symptom, and knowing prevention methods were significantly associated with awareness of individuals towards COVID-19 pandemic. Respondents who did know all prevention methods (AOR: 8.1, 95% CI: 1.3, 51.9) are more likely to aware of COVID-19 than their counterparts.Conclusion: The study showed that there is a low awareness status among people towards COVID-19.Hence, programs to improve awareness towards COVID-19 pandemic is is essential to prevent and control the pandemic.
Assessing the play and learning environments of children under two years in peri-urban Lima, Peru: A formative research study
Authors: Rothstein Jessica D , Buckland Audrey J , Gagnier Kristin , Ochoa Mayra , Allen-Valley Aliya , Jivapong Belinda , Cabrera Lilia Z , Leontsini Elli , Fisher Kelly R 
Published: January 2021

Abstract
Background : Home-based interventions have potential for improving early child development (ECD) in low-resource settings. The design of locally acceptable strategies requires an in-depth understanding of the household context. In this formative research study, we aimed to characterize the home play and learning environments of children 6-23 months of age from low-income households in peri-urban Lima, Peru. Methods : Drawing on the developmental niche framework, we used quantitative and qualitative methods to understand children’s physical and social settings, childcare practices, and caregiver perspectives. We conducted interviews, unstructured video-recorded observations, and spot-checks with 30 randomly selected caregiver-child dyads, 10 from each child age group of 6-11, 12-17, and 18-23 months of age, as well as key informant interviews with 12 daycare instructors. We analyzed the data for key trends and themes using Stata and ATLAS.ti and employed an adapted version of the Indicator of Parent-Child Interaction to evaluate the observations. Results : Children’s social settings were characterized by multi-generational homes and the presence of siblings and cousins as play partners. Access to books and complex hand-eye coordination toys (e.g., puzzles, building blocks) in the home was limited (30.0% and 40.0%, respectively). Caregivers generally demonstrated low or inconsistent levels of interaction with their children; they rarely communicated using descriptive language or introduced novel, stimulating activities during play. Reading and telling stories to children were uncommon, yet 93.3% of caregivers reported singing to children daily. On average, caregivers ascribed a high learning value to reading books and playing with electronic toys (rated 9.7 and 9.1 out of 10, respectively), and perceived playing with everyday objects in the home as less beneficial (rated 6.8/10). Daycare instructors reinforced the problems posed by limited caregiver-child interaction and supported the use of songs for promoting ECD. Conclusions : The features of the home learning environments highlighted here indicate several opportunities for intervention development to improve ECD. These include encouraging caregivers to communicate with children using full sentences and enhancing the use of everyday objects as toys. There is also great potential for leveraging song and music to encourage responsive caregiver-child interactions within the home setting.
Is There a Health Inequality in Gambling Related Harms? A Systematic Review
Authors: Raybould Jodie , Larkin Michael , Tunney Richard 
Published: January 2021

Abstract
Background: Here we present a systematic review of the existing research into gambling harms, in order to determine whether there are differences in the presentation of these across demographic groups such as age, gender, culture, and socioeconomic status, or gambling behaviour categories such as risk severity and participation frequency. Primary and Secondary Outcome Measures: Inclusion criteria were: 1) focus on gambling harms; 2) focus on harms to the gambler rather than affected others; 3) discussion of specific listed harms and not just harms in general terms. Exclusion criteria were: 1) research of non-human subjects; 2) not written in English; 3) not an empirical study; 3) not available as a full article.Methods: We conducted a systematic search using the Web of Science and Scopus databases in August 2020. Assessment of quality took place using Standard Quality Assessment Criteria.Results: A total of 59 studies published between 1994 and 2020 met the inclusion criteria. These were categorised into thematic groups for comparison and discussion. There were replicated differences found in groups defined by age, socioeconomic status, education level, ethnicity and culture, risk severity, and gambling behaviours. Conclusion: Harms appear to be dependent on specific social, demographic and environmental conditions that suggests there is a health inequality in gambling related harms. Further investigation is required to develop standardised measurement tools and to understand confounding variables and co-morbidities. With a robust understanding of harms distribution in the population, Primary Care Workers will be better equipped to identify those who are at risk, or who are showing signs of Gambling Disorder, and to target prevention and intervention programmes appropriately.