bluuebunny/crossref_metadata_2025_split huggingface dataset:
Los conceptos aristotélicos de ἐπιστήμη y σοφία en la Metafísica Α-α, y su correlato en el Protréptico
Authors: Seggiaro Claudia 
Published: October 2019

El objetivo de nuestro trabajo es indagar la concepción de ἐπιστήμη y de sof¤a en los dos primeros libros de la Metafísica, esto es, en A-α, así como su correlatoen el Protréptico de Aristóteles. En la primera parte, analizaremos el concepto de ciencia y sabiduría en los dos primeros libros de la Metafísica. En la segunda, intentaremos rastrear esta concepción en el Protréptico con el fin de establecer un posible juego de continuidades y rupturas entre ambas obras.
Las cartas en yaqui de Juan "Bandera"
Authors: Dedrick John M. 
Published: October 2019

Eleven letters —ten of them in the Yaqui language — written concerning the famous native leader Juan Ignacio Jusacamea, 'Bandera', during the period from July 1, 1830, to November 8, 1832, are transcribed, translated and introduced in this article. These extremely valuable testimonies preserved at the Bancroft Library, attracted the interest of the late Edward H. Spicer who provided John Dedrick with a copy of them. These letters constitute one of the earliest examples of written Yaqui. What is probably the oldest available text in Yaqui has been published also in Tlalocan, V. 8, 279-288.
Un título primordial de San Francisco Yatee, Oaxaca
Authors: Romero Frizzi María de los Ángeles , Vázquez Vázquez Juana 
Published: October 2019

El propósito de este trabajo es dar a conocer el Título Primordial de San Francisco Yatee, una comunidad zapoteca localizada en la sierra al norte de la ciudad de Oaxaca, México, en la región que comúnmente se conoce como de los zapotecos cajonos. El título consta actualmente de 13 fojas pero el original debió de ser más extenso, está escrito únicamente en zapoteco en la variante que el Instituto Nacional de las Lenguas Indígenas clasifica como la variante didxa shiza’ o didza shon o zapoteco serrano del sureste. La importancia de dar a conocer este documento radica en el hecho de que su original por desgracia se ha extraviado y únicamente se conservan unas fotocopias. Al igual que otros títulos primordiales éste pertenece a una antigua tradición mesoamericana que se prolongó durante la época colonial, su riqueza radica en que nos permite conocer mejor los cambios y las variantes del zapoteco así como la forma como los zapotecos entendieron diversos eventos que tuvieron lugar a raíz de la conquista espa.ola.
REKLAMLARDA ÇOCUKLARA YÖNELİK KULLANILAN SÖYLEMLER: KOTON ÖRNEĞİ
Authors: GÜNER KOÇAK Pınar , ALTİNCİK Hasan 
Published: October 2019

İnsanlar doğdukları an
itibariyle birer tüketici olmaktadır. Tüketim tercihlerinde yetişkinler kendi
başlarına karar verebilirken, çocuk tüketicilerde ihtiyaçların karşılanması
konusunda ebeveynler çocukları için karar vermektedirler. Çocuklar kendi
başlarına ihtiyaçlarını karşılamak konusunda yeterli olamasalar da
ihtiyaçlarını karşılamak için ailelerini yönlendirebilmektedirler. Geçmişte çocukların
ihtiyaçlarının ne olduğuna aileleri karar vermekteyken ve ailelerinin onlar
için aldıklarıyla yetinebilirlerken, günümüzde çocuklar ailelerini ihtiyaçları
ve istekleri konusunda yönlendirmekte ve bu noktada zaman zaman baskı
yapabilmektedir. Bu istek ve ihtiyaçlardaki çeşitlenmenin önemli sebeplerinden
biri işletmelerin, kurumların ve markaların popüler kültür içerisinde yetişen
çocuk hedef kitlenin aileler üzerindeki duygusal yaptırım gücünün farkına
varmalarıdır. Çocukları birer tüketici olarak dikkate alan ve çocuklara yönelik
ürün ve hizmet üreten birçok firma ve marka çocukların dikkatlerini çekebilmek
için birden çok yöntem kullanmaktadır. Bunların başında da dikkat çekici
görselleri olan, eğlenceli müzikleri olan ve çocukların kullanıldığı reklamlar
gelmektedir. Popüler kültürün önemli araçlarından olan reklamlar aracılığıyla
çocuklara ihtiyaçları ve beklentileri öğretilmektedir. Bu çalışma ile Koton
Kids ürünlerinin reklamlarında çocuk hedef kitleler için kullanılan söylemlerin
benzer yaş gruplarının zihinsel ve fiziksel gelişimi dikkate alınarak analiz
edilmesi amaçlanmıştır. Bu kapsamda reklamda çocuk oyuncuların söylemleri Van
Dijk’in eleştirel söylem analizi kullanarak incelenmiş ve bu reklamlarda
kullanılan söylemlerin geleneksel aile yapısı içerisinde yetişen çocuklarda
zamanla oluşabilecek toplumsal çelişkiler bağlamında değerlendirilmiştir. Araştırma sonucunda çocukların öğrenme
sürecinde sosyal öğrenmenin ve taklit süreçleri değerlendirildiğinde Koton
reklamlarının çocuklar için olumsuz örnekler de teşkil edebileceği sonucuna
ulaşılabilmektedir.
QUALIDADE DA ÁGUA SUBTERRÂNEA E TRATAMENTO SIMPLIFICADO PARA ABASTECIMENTO HUMANO DO INSTITUTO ETERNA MISERICÓRDIA DE LAVRAS-MG
Authors: Ribeiro Paola Gonçalves , Pereira Ivonaldo , Santos Caio César  Andrade dos , Franco Camila Silva , Marques Rosângela Francisca de Paula Vitor 
Published: October 2019

Sistemas de saneamento descentralizados em áreas escassamente povoadas pode promover abastecimento de água potável, simplificado e a baixo custo. O Instituto de Acolhimento e Recuperação Eterna Misericórdia (IAREM), em Lavras-MG, é uma associação civil, sem fins lucrativos, que acolhe cerca de 60 homens em situação social precária. Nesse sentido, objetivou-se avaliar a situação da qualidade de água de abastecimento proveniente de poço subterrâneo e propor melhorias visando garantir fornecimento de água potável de qualidade. Foram coletadas amostras dos poços semi-artesiano e artesiano e em três pontos de consumo do IAREM, no período seco e chuvoso. Foram realizadas análises de potabilidade de água segundo os padrões de potabilidade da Portaria 2914/2011 do Ministério da Saúde . Para amostras positivas de coliformes termotolerantes, realizou-se ensaios de desinfecção por meio de radiação UV. Observaram-se valores médios de Manganês e coliformes termotolerantes acima dos padrões estabelecidos pela Portaria MS 2914/2011. A desinfecção por radiação ultravioleta mostrou-se eficaz na inativação de coliformes termotolerantes para uma lâmina de 20 cm e 120 s de exposição em ensaios experimentais. No entanto, a cloração também é sugerida também como alternativa para o processo de desinfecção da água de abastecimento do IAREM.
Multi-Projector Calibration Based on Virtual Viewing Space
Authors: Xizuo Liu , Yan Lin , Xiaogang Xu , Liang Ma 
Published: October 2019

In large-scale maritime maneuvering simulators, the multi-channel systems are usually used to tile multiple projectors on a cylindrical display to create a large virtual environment, which brings more realistic immersion to the users. In the non-planar multi-projector display system, to finish the work of geometric and photometric corrections, there exist the problems of difficult projector calibration, more manual intervention and poor adaptability. In order to solve these problems, a multi-projector calibration based on virtual viewing space is proposed in this paper. First, a virtual environment of multiple projectors is created, and by using the structured light and re-projection model on a cylindrical wall, the calibration of internal and external parameters of a projector are realized separately. Finally, the geometric correction is completed by the mapping relationship between the target images and the calibrated re-projected images. This method is free of limitation by the angle of view of a single camera and can calibrate any of the projectors in the multi-channel systems. The example results show that the projector’s parameters can be estimated more accurately, and the efficiency and accuracy of geometric correction can be improved. Good results are achieved when applying this method in the maritime maneuvering simulator system.
Microscopic features of small bowel mucosa of patients with Crohn’s disease
Authors: cui yun , Lu Shi-yuan , Xu Jie , Peng Yan-shen , Miao Qi , wang xiao-qing , Chen Xiao-yu , Ran Zhi-hua 
Published: October 2019

Abstract
Background Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aimed to explore the small bowel mucosal histopathologic characters of Crohn’s disease and identify some disease-specific changes. Methods We included 253 patients without tumors and grouped them into Crohn’s disease, suspected Crohn’s disease, and non-Crohn’s disease groups. These patients underwent double-balloon endoscopy examination and small bowel biopsy at Renji Hospital, Shanghai. All histopathological sections were reviewed, and >20 histopathological parameters were assessed. Immunohistochemistry was conducted when necessary. Results There were different forms of granulomatous lymphangitis on the small bowel mucosa in Crohn’s disease. They showed as various macrophages or epithelioid cells in the lumina of lymphatics or in the center of the villi with or without evident obstruction. These features were only observed in Crohn’s disease patients. Furthermore, they were correlated with granuloma and lymphangiectasia. Additionally, 15 other features showed significant differences among the three groups, and Crohn’s disease patients showed an average of almost seven histopathological characteristics. Conclusions We described the detailed morphologies of granulomatous lymphangitis on the small bowel mucosa and recommend it as a useful histopathological feature for the diagnosis of Crohn’s disease. In terms of specificity and sensitivity, it was superior to non-caseating epithelioid granuloma.
The predictors and patterns of the early recurrence of pancreatic ductal adenocarcinoma after pancreatectomy: the influence of pre- and post- operative adjuvant therapy
Authors: Suto Hironobu , Okano Keiichi , Oshima Minoru , Ando Yasuhisa , Takahashi Shigeo , Shibata Toru , Kamada Hideki , Kobara Hideki , Masaki Tsutomu , Suzuki Yasuyuki 
Published: October 2019

Abstract
Background The perioperative factors predicting or influencing early pancreatic ductal adenocarcinoma recurrence are unclear. This study attempted to identify the predictive factors for early pancreatic ductal adenocarcinoma recurrence post-pancreatectomy and the influence of pre- and post- operative adjuvant therapy.
Methods One hundred and fifteen patients undergoing curative resection for pancreatic ductal adenocarcinoma between 2000 and 2016 at our institution were retrospectively analyzed. Patients were divided into two groups: those who did (n=34) and did not (n=81) experience a recurrence within 6 months postoperatively.
Results Multivariate analyses demonstrated postoperative CA19-9 de-normalization, no postoperative adjuvant chemotherapy, and serosal invasion were independent risk factors for early recurrence (P<0.001, P=0.001, and P=0.010, respectively). A subgroup analysis showed patients with (n=51) and without (n=64) preoperative chemoradiotherapy had different predictors. Although postoperative adjuvant chemotherapy was not a significant indicator in patients with preoperative chemoradiotherapy, CA19-9 de-normalization and no postoperative adjuvant chemotherapy were significant indicators in patients without preoperative chemotherapy. Preoperative chemotherapy strongly prevented early local recurrence while postoperative adjuvant chemotherapy prevented early distant recurrence.
Conclusions CA19-9 de-normalization was an important predictor of early recurrence of pancreatic ductal adenocarcinoma. Although postoperative adjuvant chemotherapy was an important preventive measure against early recurrence, particularly for distant recurrence, preoperative chemoradiotherapy could strongly prevent the early local recurrence of pancreatic ductal adenocarcinoma. These perioperative adjuvant therapies could have a complementary relationship.
Sri Lankan nurses’ Knowledge, Attitude and Practice towards use of physical restraints in psychiatric patients
Authors: Dasanayake Navodya Sewwandi , Nethmini Virangi Indrachapa , Kumari Nishanthi Manjula , Peiris Kumudumali Hansika , Vijayachithra Ganeshmurthi , Gunarathna Susil Menaka , Galgamuwa Lahiru Sandaruwan , Kumara Chandima , Fernando Neil 
Published: October 2019

Abstract
Background

Physical restrain was one of the ancient interventions used to control psychiatric patients. It should be used for a short period, and a registered nurse is responsible to protect rights, treat with dignity and provide high quality care during patient restraints. The objective of the study was to assess knowledge, attitudes and practices on physical restraining among nurses in psychiatric wards and units in Sri Lanka.Methods

A study was conducted in a Mental Health institution in Sri Lanka and a pretested self-administered questionnaire was used for data collection. The associations among the knowledge, attitudes, practices and socio-demographic factors were assessed.Results

Knowledge of nursing officers’ regarding physical restraints was at a satisfactory level and increasing with working experience, getting formal education of physical restraining. However, there is no significant association between the knowledge on physical restraints and working experience, formal education of physical restraints and working places. In addition, most of attitudes and practices regarding physical restraints among nurses were not significantly associated with working experience, formal education of physical restraints and working places.Conclusions

Knowledge, attitudes and practices regarding physical restraints among nurses were in satisfactory level. Continuous in-service education programs are important to improve knowledge, attitudes and practices on physical restraints for psychiatry patients.
Bile acids inhibit Notch-1 expression in the development of Barrett’s esophagus
Authors: Sun Dongfeng , Hu Wensi , Chen Chengyu , Gai Zhibo , Fan Limin , Zhong Chenxi 
Published: October 2019

Abstract
Background: Barrett’s esophagus (BE) is the premalignant condition for the development of esophageal adenocarcinoma, and occurs when the stratified epithelium is replaced by an intestinal-type epithelium with goblet cells. Bile acids (BAs) may play a dominant role in esophageal metaplasia, which is characterized by the expression of intestine-specific nuclear transcription factor caudal type homeobox transcription factor 2 (CDX-2). Notch-1 is frequently downregulated in BE, and protects squamous epithelia from becoming malignant and inducing intestinal metaplasia. However, the molecular mechanisms of this pathway are unclear. Methods: We first investigated Notch-1 and CDX-2 in human BE epithelium. Then Wister rats were used to develope animal models to test the role of BAs in the pathogenesis of BE. Effects of deoxycholic acid (DCA) on Notch-1 and CDX-2, as well as Notch signaling pathway blockage with DATP or with si-Hes-1 in vitro were observed through RT–PCR and western blotting techniques in human EAC cells (OE-19) and esophageal epithelial cells (Het-1a). Results: We found that the Notch -1 gene was inhibited in human and rodent BE specimens and BAs induced Barrett’s-like metaplasia. DCA decreases Notch-1 in a time and concentration dependent manner in both EAC cells (OE-19) and esophageal epithelial cells (Het-1a). Notch signaling inhibition increased CDX-2 expression but also blocked the influence of DCA. Conclusions: These data imply that BAs induce BE by inhibiting Notch-1 in esophageal cells. Notch signal pathway inhibition presents a therapeutic strategy for premalignant conditions of the esophagus.
Building collective power in citizen-led initiatives for health accountability in Guatemala: The role of networks
Authors: Hernandez Alison , Hurtig Anna-Karin , Goicolea Isabel , Sebastian Miguel San , Jerez Fernando , Hernandez-Rodriguez Francisco , Flores Walter 
Published: October 2019

Abstract
Background
Citizen-led accountability initiatives are a critical strategy for redressing the causes of health inequalities and promoting better health system governance. A growing body of evidence points to the need for putting power relations at the forefront of understanding and operationalizing citizen-led accountability, rather than technical tools and best practices. In this study, we apply a network lens to the question of how initiatives build collective power to redress health system failures affecting marginalized communities in three municipalities in Guatemala.
Methods
Network mapping and interpretive discussions were used to examine relational qualities of citizen-led initiatives’ networks and explore the resources they offer for mobilizing action and influencing health accountability. Participants in the municipal-level initiatives responded to a social network analysis questionnaire focused on their ties of communication and collaboration with other initiative participants and their interactions with authorities regarding health system problems. Discussions with participants about the maps generated enriched our view of what the ties represented and their history of collective action and also provided space for planning action to strengthen their networks.
Results
Our findings indicate that network qualities like cohesiveness and centralization reflected the initiative participants’ agency in adapting to their sociopolitical context, and participants’ social positions were a key resource in providing connection to a broad base of support for mobilizing collective action to document health service deficiencies and advocate for solutions. Their legitimacy as “representatives of the people” enabled them to engage with authorities from a bolstered position of power, and their iterative interactions with authorities further contributed to develop their advocacy capabilities and resulted in accountability gains.
Conclusions
Our study provided evidence to counter the tendency to underestimate the assets and capabilities that marginalized citizens have for building power, and affirmed the idea that best-fit, with-the-grain approaches are well-suited for highly unequal settings characterized by weak governance. Efforts to support and understand change processes in citizen-led initiatives should include focus on adaptive network building to enable contextually-embedded approaches that leverage the collective power of the users of health services and grassroots leaders on the frontlines of accountability.
Integrated Use of the GeneXpert Platform for TB, HIV and EVD testing in Liberia
Authors: Desta Kassaye Tekie , Dogba John B. , Garbo Julia Toomey , Kessely Dedeh B. , Eastman Candace B. , Daboi Jerry G. 
Published: October 2019

Abstract
Background: The capacity for molecular testing of Human Immunodeficiency Virus (HIV) Viral load, Tuberculosis (TB) and epidemic prone disease was very limited in Liberia prior to the Ebola Virus Diseases (EVD) outbreak. The use of point of care and near point of care machines for multiple disease testing of HIV, TB and EVD was adopted as a solution to these challenges. The purpose of this study was to evaluate the integrated use of the GeneXpert for the three diseases testing. Methods: A previously collected and reported GeneXpert testing data was used to evaluate the integrated use of GeneXpert platform for TB, HIV viral load and EVD testing. All the laboratory GeneXpert secondary data available since the machines were installed and started testing were analyzed. Besides; Field observation report on the operation, coordination and impact of the integrated testing was included. Results: The integrated testing of HIV Viral load, Mycobacterium Tuberculosis/Rifampicin (MTB/RIF) and EVD using the GeneXpert platform has played a significant role in Liberia. A total of 706 HIV viral load, 3695 MTB/RIF and 2309 EVD GeneXpert tests were conducted since the start of the integrated testing. Conclusion: The integrated use of the GeneXpert platform for TB, HIV and EVD is very crucial as it helped in enhancing the services and coordinating resources in a sustainable way. Lessons learnt from this integration will help to effectively scale up the integrated testing.
Prognostic value of preoperative inflammatory markers in patients with different molecular subgroups of WHO grade II and III diffuse gliomas
Authors: Qi Zengxin , Cai Jiajun , Meng Xiangda , Cai Shengyong , Tang Chao , Lang Liqin 
Published: October 2019

Abstract
Objective: To determine the prognostic implications of these immune indices in WHO Grade II & III gliomas and different molecular subgroups.Methods : Clinical data from 214 newly diagnosed WHO grade II and III diffuse glioma patients were studied retrospectively. Cut-off values were determined by X-tile software. IDH and TERT promotor mutations were detected by gene sequencing, and 1p19q co-deletion was estimated via fluorescence in situ hybridization.Results: NLR was verified to be an independent prognostic marker for OS in WHO grade II and III diffuse gliomas. NLR level was also associated with OS of IDH mutant subgroup, TERT promotor mutant subgroup, 1p19q intact subgroup and with PFS of 1p19q intact subgroup. LMR level was associated with OS of WHO grade II and III diffuse gliomas and TERT promotor mutant subgroup. dNLR was verified to be an independent prognostic marker for OS in TERT promotor wild-type subgroup, 1p19q intact subgroup, IDH mutant TERT promotor wild-type 1p19q intact subgroup and for PFS of 1p19q intact subgroup. dNLR was associated with OS of WHO grade II and III diffuse gliomas and IDH mutant subgroup. 1p19q co-deletion was correlated with low NLR. Conclusion: Preoperative NLR, LMR and dNLR levels were helpful to forecast prognosis in patients with WHO grade II and III gliomas and different genetic phenotypes.
The impact of contemporary treatments on the perioperative care of children with mucopolysaccharidoses: A case series and review of the literature.
Authors: Stuart Grant , Pehora Carolyne , Wong Gail 
Published: October 2019

Abstract
Background: Patients with mucopolysaccharidosis (MPS) present significant perioperative challenges. We aimed to document the perioperative care of children with MPS undergoing anesthesia and to describe the impact of hematopoietic stem cell transplantation (HSCT) or enzyme replacement therapy (ERT) on the anesthetic management of these patients. Methods: We performed a retrospective chart review of patients with MPS anesthetised for surgical or investigative procedures at the Hospital for Sick Children in Toronto between January 2000 and December 2014. Data on MPS treatment, co-morbidities, anesthetic techniques, airway management, post-operative care and perioperative complications were collected. Results: 66 children with MPS underwent 332 anesthetics for 345 procedures. The overall rate of difficult airway was 42%. Of 29 patients with MPS I (Hurler syndrome), 66% were treated with HSCT and 34% with ERT. In those treated with HSCT, 19% had difficult airways, compared with 67% in patients who received neither treatment. 90% of patients with MPS II (Hunter syndrome) had difficult airways. ERT did not improve airway difficulty in MPS I or II patients. 32% of all anesthetics were conducted without airway instrumentation. Direct laryngoscopy, was used in 26% of all anesthetics, the laryngeal mask airway in 26%, fibreoptic bronchoscope in 7%, and video laryngoscope in 5%.Conclusions: Patients with MPS I who have had HSCT are less likely to have a difficult airway compared with those not treated with HSCT. ERT in MPS I and II patients did not alter the incidence of difficult airway. A third of MPS patients underwent anesthesia for diagnostic imaging or minor interventional radiology procedures without airway instrumentation.