bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scanxiety and Fear of Recurrence in Young Adult Female Breast and Gynaecological Cancer Survivors: Investigating Shared Mechanisms
Authors: Patel Diya S. , Webster Sarah N. , Dowling Emily J. , Knowles Claudia R. , Lockwood‐Taylor Georgina , Coutts‐Bain Daelin , Simons Laura E. , Diver Elisabeth J. , Chilcot Joseph , Schapira Lidia , Heathcote Lauren C. 
Published: December 2024

ABSTRACTBackgroundAdolescent and young adult (AYA) females are vulnerable to psychological sequelae following cancer diagnosis and treatment. Fear of cancer recurrence (FCR) is well‐documented in cancer survivors, however AYA survivors of breast and gynaecological cancers are less well‐studied. Moreover, little is known about scan‐related fears and anxiety (‘scanxiety’) in survivors of any age group.AimsThis study aimed to assess demographic, medical, and quality‐of‐life correlates of FCR and scanxiety in AYA female breast and gynaecological cancer survivors post‐treatment. Additionally, we explored potential shared mechanisms of FCR and scanxiety, including intolerance of uncertainty, bodily threat monitoring, and perceived stress.MethodsAYA breast and gynaecological cancer survivors (N = 115) completed measures of FCR, scanxiety, intolerance of uncertainty, bodily threat monitoring, perceived stress, and quality of life. Bivariate associations and a structural equation model explored relationships between these variables.ResultsBoth FCR and scanxiety were prevalent, with 84% reporting clinically meaningful FCR and 38% reporting severe FCR. Higher FCR and scanxiety were both associated with poorer quality of life. FCR and scanxiety were moderately associated but not entirely overlapping. Intolerance of uncertainty, bodily threat monitoring, and perceived stress were significantly correlated with both FCR and scanxiety. The structural equation model indicated that bodily threat monitoring is a plausible intermediate variable linking intolerance of uncertainty and FCR, but not scanxiety.ConclusionsFCR and scanxiety are common in AYA survivors of breast and gynaecological cancers, with potentially distinct underlying mechanisms. Interventions targeting intolerance of uncertainty and bodily threat monitoring may reduce FCR, while further research is needed to identify therapeutic targets for scanxiety.
Hypnosis for Antineoplastic‐Related Taste Disturbance in a Patient With Metastatic Breast Cancer
Authors: Saperia Corey , Tran Nathan , Zewde Nahom , Spiegel David 
Published: December 2024

ABSTRACTTaste disturbances are prominent side effects of antineoplastic medications and contribute to morbidity and quality‐of‐life impairment. Few treatment options are available for antineoplastic‐related taste disorders. Hypnosis has been found to be effective for a variety of symptoms in the cancer setting, including insomnia, pain, mood disorders and anxiety. Numerous somatosensory perceptual changes have been observed with hypnosis, including perception of tactile stimuli and color. Here, we report a case of a 74‐year‐old woman with recurrent metastatic breast cancer presenting with an 18‐month history of antineoplastic‐related hypogeusia. She was treated with hypnosis and reported resolution of taste symptoms after 10 days of daily practice. Her improvement seems to be related to hypnotic changes in somatosensory perception, which may be associated with functional alterations in salience, executive control and default mode networks during hypnosis. Further investigation of hypnosis for antineoplastic‐related taste disturbances is indicated.
Etiology and clinical features of children with bronchiectasis—Insight from Chinese experience
Authors: Han Peng , Shen Kunling 
Published: December 2024

AbstractBronchiectasis is a clinical syndrome characterized by cough, sputum production, and the presence of abnormal thickening and dilation of the bronchial wall on imaging. There has been a remarkable resurgence in incidence and prevalence during the past 20 years. There was few data from children. In China, it has been estimated that 1.5% of women and 1.1% of men in the general population have physician‐diagnosed bronchiectasis.
Natural Compounds and Their Analogs as Antivirals Against Dengue Virus: A Review
Authors: Komarudin Amalina Ghaisani , Adharis Azis , Sasmono R. Tedjo 
Published: December 2024

ABSTRACTDengue virus (DENV) continues to pose a significant global health challenge, causing diseases such as dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. While efforts in vaccine development and antiviral drug discovery are ongoing, effective therapeutic options remain limited. In this review, we highlight natural compounds and the analogs that demonstrated antiviral activity against DENV in in vitro and in vivo studies. Specifically, these studies examine alkaloids, phenolic acids, phenols, flavonoids, terpenoids, and glycosides which have shown potential in inhibiting DENV entry, replication, and reducing the cytokine storm. By focusing on these bioactive compounds and the analogs, a comprehensive overview of their promising roles is provided to advance therapeutic strategies for combating DENV infection.
Development of a Matrix‐Assisted Laser Desorption Ionization High Resolution Mass Spectrometry Method for the Quantification of Camalexin and Scopoletin in Arabidopsis thaliana
Authors: Parasecolo Leonardo , Monsalvo Ivan M. , Kovinich Nikola , Ifa Demian R. 
Published: December 2024

ABSTRACTRationaleUnderstanding plant defense mechanisms against pathogens is essential for enhancing agricultural productivity and crop protection. This study focuses on the quantification of camalexin and scopoletin, two critical phytoalexins in Arabidopsis thaliana, using mass spectrometry techniques. Precise measurement of these compounds provides insights into plant resistance and supports agricultural research.MethodsCamalexin and scopoletin were quantified using matrix‐assisted laser desorption ionization high‐resolution mass spectrometry (MALDI‐HRMS). The matrix and solvent conditions were optimized to maximize sensitivity and accuracy. MS/MS experiments confirmed compound identification with high mass accuracy (mass error < 5 ppm). The method was validated through comparative analysis of wild‐type (WT) and mutant Arabidopsis lines, using internal standards and multiple replicates to ensure precision and reliability.ResultsThe method exhibited high linearity for scopoletin (R2 = 0.9992) and camalexin (R2 = 0.9987) across concentration ranges of 0.16–5 and 0.31–5 μM, respectively. Limits of detection (LOD) were 0.16 μM for camalexin and 0.04 μM for scopoletin, with limits of quantification (LOQ) at 0.2 μM and 0.08 μM, respectively. Samples analysis demonstrated reliable quantification in WT and mutant lines, with significant reductions in camalexin and scopoletin levels observed in the atwrky33‐2 and atmyb15‐1 mutants, respectively. Additionally, the method detected sub‐physiological concentrations, confirming its sensitivity and robustness for low‐level detection.ConclusionsThis study presents a validated, precise, and accurate MALDI‐HRMS method for the quantification of camalexin and scopoletin in Arabidopsis thaliana. The approach not only enhances understanding of plant defense mechanisms but also offers potential applications for biotechnological and agricultural research, especially for investigating genetic variations and stress‐induced phytoalexin production.
Using Electrical Impedance Spectroscopy to Separately Quantify the Effect of Strain on Nanosheet and Junction Resistance in Printed Nanosheet Networks
Authors: Caffrey Eoin , Carey Tian , Doolan Luke , Dawson Anthony , Coleman Emmet , Sofer Zdeněk , Cassidy Oran , Gabbett Cian , Coleman Jonathan N. 
Published: December 2024

AbstractMany printed electronic applications require strain‐independent electrical properties to ensure deformation‐independent performance. Thus, developing printed, flexible devices using 2D and other nanomaterials will require an understanding of the effect of strain on the electrical properties of nano‐networks. Here, novel AC electrical techniques are introduced to fully characterize the effect of strain on the resistance of high‐mobility printed networks, fabricated from of electrochemically exfoliated MoS2 nanosheets. These devices are initially characterized using DC piezoresistance measurements and show good cyclability and a linear strain response, consistent with a low gauge factor of G ≈ 3. However, AC impedance spectroscopy measurements, performed as a function of strain, allow the measurement of the effects of strain on both the nanosheets and the inter‐nanosheet junctions separately. The junction resistance is found to increase linearly with strain, while the nanosheet resistance remains constant. This response is consistent with strain‐induced sliding of the highly‐aligned nanosheets past one another, without any strain being transferred to the sheets themselves. The approach allows for the individual estimation of the contributions of dimensional factors (G ≈ 1.4) and material factors (G ≈ 1.9) to the total gauge factor. This novel technique may provide insights into other piezoresistive systems.
Single‐Molecule Electrical Conductance in Z‐form DNA:RNA
Authors: Aguilar Mauricio R. , Jover Jesus , Ruiz Eliseo , Aragonès Albert C. , Artés Vivancos Juan M 
Published: December 2024

AbstractNucleic acids have emerged as new materials with promising applications in nanotechnology, molecular electronics, and biosensing, but their electronic properties, especially at the single‐molecule level, are largely underexplored. The Z‐form is an exotic left‐handed helical oligonucleotide conformation that may be involved in critical biological processes such as the regulation of gene expression and epigenetic processes. In this work, the electrical conductance of individual Guanine Cytosine (GC)‐rich DNA:RNA molecules is measured in physiological buffer and 2,2,2‐Trifluoroethanol (TFE) solvent, corresponding to the natural (right‐handed helix) A‐form typical in DNA:RNA hybrids and the (left‐handed) Z‐form conformations, respectively. Single‐molecule conductance measurements are performed using the Scanning Tunneling Microscopy (STM)‐assisted break‐junction method in the so‐called “blinking” approach, recording the spontaneous formation of single‐biomolecule junctions and performing statistical analysis of the signals. Circular Dichroism (CD) experiments and ab initio calculations are also done to rationalize the measured molecular conductivity with a simple structural and electronic model. These results show that the electrical conductivity of the Z‐form is one order of magnitude lower than that of the more compact A‐form. The longer molecular length and higher energy for the Highest Occupied Molecular Orbital (HOMO) of the Z‐form account for the differences in single‐molecule conductance observed experimentally.
Constructing Lewis Acid–Base Pairs to Boost Electrocatalytic Hydrogenation of p‐Nitrobenzoic Acid to Valuable p‐Aminobenzoic Acid Using Water as the Hydrogen Source
Authors: Xu Gang , Dong Shi‐Jiao , Liu Han‐Jian , Wang Wen‐Biao , Zhang Xi‐Min , Cai Mei‐Qing , Sun Jiansong , Song Jun‐Ling 
Published: December 2024

AbstractElectrocatalytic hydrogenation of toxic nitrobenzene to value‐added aniline is of great significance in addressing the issues of energy crisis and environmental pollution. However, it is a considerable challenging and crucial to develop highly efficient and earth‐abundant transition metal‐based electrocatalysts with superior durability for the electro‐hydrogenation of nitrobenzene due to the competitive hydrogen evolution reaction (HER). In this work, a facile approach is designed and introduced to constructing an integrated self‐supported heterostructured Co1‐xNix(OH)(CO3)/Al(OH)3 nanoarrays (CoNiCH/Al(OH)3) for the electrocatalytic reduction of nitrobenzoic acid (PNBA) to p‐aminobenzoic acid (PABA) and its electrocatalytic mechanism for PNBA reduction is investigated. This unique Lewis acid–base pairs with abundant oxygen vacancies (OVs) can effectively regulate the adsorption energy of PNBA and active hydrogen intermediates, facilitate the proton‐coupled electrocatalytic reduction process, leading to the high activity and selectivity for PNBA to PABA. The optimal CoNiCH/Al(OH)3‐0.5 exhibits outstanding performance for the electrocatalytic hydrogenation of PNBA to PABA with a yield of 92%, selectivity of 95% and Faraday efficiency (FE) of 92% at ‐0.545 V (vs reversible hydrogen electrode, RHE) under 0.1 m phosphate buffered solution (PBS) neutral electrolyte. Besides, it can maintain a high electrocatalytic activity for at least eight electrocatalytic cycle‐test.
Translanguaging Formative Assessment Tools for Bilingual Teachers of Multilingual Students
Authors: Rodriguez‐Mojica Claudia , Briceño Allison , Rutherford‐Quach Sara , Stoehr Kathleen Jablon 
Published: December 2024

ABSTRACTIn this article, the authors describe how their NPD project aims to support bilingual classroom teachers' understanding and implementation of translanguaging as theory and practice. They share two practical tools they developed to help teachers approach formative assessment through a translanguaging lens. The first tool is a classroom conversation observation tool that equips teachers to capture what focal students can do in conversations about grade level content in Spanish, English, and via translanguaging. Tool 1 is aligned with the Common Core Speaking and Listening standards and includes a blank template teachers can use to align the tool with relevant standards across content areas and grade levels. The second tool is designed to help teachers (1) get to know a student as a holistic individual, (2) use that information to identify high‐interest books for the student, and (3) employ culturally and linguistically responsive adaptations, such as translanguaging, to formatively assess the student's reading. Both tools are intended to guide instruction via informal formative assessment: Identifying students' strengths and needs helps distinguish aspects of language and literacy necessary for future instruction.
Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain
Authors: Saenz Camila , Fernandez Gimena , Llovera Ramiro , Tolosa María J. , Cantel Sonia , Fehrentz Jean-Alain , Mackie Kenneth , Leggio Lorenzo , Zigman Jeffrey , De Francesco Pablo N. , Perello Mario 
Published: December 2024

Abstract
The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses. GHSR mediates the effects of both ghrelin and liver-expressed antimicrobial peptide 2, while CB1R is targeted by cannabinoids. Strikingly, both receptors mediate their effects by acting on common brain areas and their individual roles have been well characterized. However, the potential for their co-expression in the same neuronal subsets remains largely unexplored. Here, we aim to map the cell populations where GHSR and CB1R might converge, hypothesizing that their co-expression in specific brain circuits could mediate integrated physiological responses. By utilizing two complementary labeling techniques—GHSR-eGFP mice and Fr-ghrelin labeling of GHSR+ cells—along with specific CB1R immunostaining, we sought to visualize and quantify potential areas of overlap. Also, we analyzed several cell RNA sequencing datasets to estimate the fraction of brain cells expressing both GPCRs and their phenotype. Our neuroanatomical studies revealed evident overlap of GHSR+ and CB1R+ signals in specific neuronal subsets mainly located in the cerebral cortex, hippocampus and the amygdala. Transcriptomic analysis revealed specific subsets of Ghsr+/Cnr1+ glutamatergic neurons in the hippocampus and amygdala, as well as different subtypes of Ghsr+/Cnr1+ neurons in the midbrain, hypothalamus, pons, and medulla. Thus, we revealed that GHSR and CB1R interact differentially across specific regions of the mouse brain, providing new insights into how these receptors' actions are integrated. Current findings may open new avenues for dual therapeutic interventions in metabolic disorders, obesity, and psychiatric conditions.
Long term inguinal pain comparing TEP to Lichtenstein repair: the TEPLICH RCT 8 years follow-up
Authors: Gutlic A. , Petersson U. , Rogmark P. , Montgomery A. 
Published: December 2024

Abstract
Purpose
To investigate long-term chronic postoperative inguinal pain (CPIP), QoL and recurrence in patients with a primary inguinal hernia comparing TEP to Lichtenstein.

Material and methods
A questionnaire-based follow-up containing the Inguinal Pain Questionnaire (IPQ), the Cunningham Pain Scale and SF-36 was done 8 years after the TEPLICH RCT. The main objective was non-ignorable pain last week according to IPQ. A phone interview was performed with patients reporting new non-ignorable pain and those having a suspected recurrence. Records were scanned for long-term CPIP and recurrences. A lost to follow-up analysis was performed.

Results
A total of 322 of 366 patients (88%) completed the follow-up of mean 7.94 years (5–10.75 years). Non-ignorable pain last week was reported by 7.6% in TEP and 6.7% in Lichtenstein (p < 0.73). New non-ignorable pain was reported by 5 patients. No difference in non-ignorable pain over time (1–8 years) was observed within groups. Moderate to severe pain, according to Cunningham, was reported by 3.8% in TEP and 5.5% in Lichtenstein (p < 0.48). QoL remained above the Swedish norm. No recurrences occurred after 3 years follow-up. The lost to follow-up analysis showed no difference in non-ignorable pain.

Conclusions
RCTs, comparing TEP to Lichtenstein repair with follow-up ≥ 5 years regarding CPIP are sparse with conflicting data. In this study, low frequencies of CPIP present at 3 years seem to persist at 8 years. Recurrences occured within the first 3 years. Patients need to be informed of the risk of long-term CPIP.
The selectivity behaviour of a TADDOL-derived host compound in selected heterocyclic guest solvents
Authors: Recchia Daniella Loridana , Barton Benita , Hosten Eric C. 
Published: December 2024

AbstractTADDOL5 possesses the ability to form complexes with the heterocyclic guest species DIO, PYR, PIP and MOR, and 1:1 (PYR, PIP, MOR) and 2:1 (DIO) H:G inclusion compounds were isolated after host crystallization experiments from these solvents. Guest competition experiments revealed that PIP and MOR were preferred by TADDOL5, while PYR and DIO were less favoured; the selectivity of this host compound for these guests was thus demonstrated to be in the order PIP > MOR > PYR > DIO. SCXRD analyses explained this host preferential order: PIP experienced the shorter and more linear (host)O‒H···N(guest) hydrogen bond with TADDOL5, followed by MOR and PYR. DIO was also retained in the crystal of the complex by means of a hydrogen bond with TADDOL5 of the (host)O‒H···O(guest) type. Hirshfeld surface investigations did not provide further understanding for the host selectivity behaviour when crystallized from mixed guests, but the relative thermal stability of the complex with preferred PIP formed the most stable complex while the inclusion compound with DIO, least favoured, was characterised by the lowest stability.
Graphical abstract
Reconsidering mechanisms in social science research: the varied uses of an explanatory metaphor
Authors: Norman Ludvig 
Published: December 2024

AbstractThis article reconsiders the role of mechanisms in social science research. The study of mechanisms has been recognized as a fundamental task for a methodologically diverse range of social scientific approaches. This raises questions of what roles mechanisms play for causal explanations and if there are uses that are more reasonable than others. To address these questions the article, first, discusses competing arguments for the causal theory underpinning mechanisms. On the basis of these discussions the paper emphasizes the heuristic role of mechanisms as an explanatory devise, serving a crucial role for causal explanations. Secondly, it endeavors to explore the diverse ways mechanisms are employed, especially in contemporary political science research, to highlight limits and benefits with different approaches. The discussion helps reconsider existing fault lines in debates over mechanisms, including the relationship between qualitative and quantitative techniques in empirical research centered on mechanistic explanations.
Seasonal and Short Timescale Changes on the Martian Surface: Multi-Spacecraft Perspectives
Authors: Thomas N. , Pommerol A. , Hauber E. , Portyankina G. , Tirsch D. , Schmidt F. , Cesar C. , Valantinas A. , Bickel V. T. , Munaretto G. 
Published: December 2024

Abstract
The continued operation of missions such as Mars Express, Mars Reconnaissance Orbiter, and the ExoMars Trace Gas Orbiter has greatly enhanced our knowledge of seasonal processes on Mars. The most apparent evidence of the importance of seasons on Mars on the large scale is annual variation in the sizes of the Martian polar caps. However, high resolution imaging has also shown that seasonal forcing can lead to small-scale phenomena that are continuously changing the topography and the surface photometry. These phenomena often have no terrestrial analogue and involve complex interactions between seasonal ices, atmosphere, and substrate (surface and sub-surface). Although we now have better understanding of many of these processes (occasionally as a result of laboratory simulation), direct proof of some hypotheses remains elusive. We provide a brief review of the phenomena and list a series of open questions.
Size-fractionated carbonaceous and iron-rich particulate matter in urban environments of France and Senegal
Authors: Delville Laurence , Léon Jean-François , Macouin Mélina , Tastevin Yann-Philippe , Demory François , Proietti Arnaud , da Silva Chibane Pedro Henrique , Dias Alves Maria , Gueye Mayoro , Laffont Laure , Gardrat Eric , Rousse Sonia , Drigo Loic , Ustra Andréa Teixeira 
Published: December 2024

Abstract
Road traffic is one of the main sources of particulate matter in the urban environment, emitting particulate organic and elemental carbon compounds and metal-rich particles through combustion and brakes and tires wear. In Western Africa, the carbon and metal composition of airborne particles is also influenced by additional sources linked to biomass combustion and recent industrialization. Here, we investigated the impact of combustion-related and non-combustion-related emissions on the distribution of carbonaceous fractions and iron-rich particles in two urban environments in France and Senegal. The supermicron fraction (

$$D_a>{1}$$

D
a

>
1

µm) showed a significantly higher isothermal remanent magnetization (SIRM) than finer fractions, accounting for 79% in France and 81% in Senegal of the total SIRM. In the submicron fraction (

$$D_a<{1}$$

D
a

<
1

µm), we noted significantly higher concentrations of total carbon (TC) and elemental carbon (EC) than for other fractions, both accounting for 71% in France and 68% and 75% in Senegal of the total and elemental particulate carbon concentration, respectively. Electron microscope observations revealed the presence of iron-rich particles for

$$D_a<{0.2}$$

D
a

<

0.2

µm, however, associated with a weak SIRM. Such iron particles may be produced by combustion or abrasion while we suspect that emissions by the abrasion process produce larger particles.