bluuebunny/crossref_metadata_2025_split huggingface dataset:
What drives the redshift evolution of strong emission line ratios?
Authors: Bian Fuyan , Kewley Lisa J , Groves Brent , Dopita Michael A 
Published: January 2020

ABSTRACT
We study the physical mechanisms that cause the offset between low-redshift and high-redshift galaxies on the [O iii] λ5007/H β versus [N ii] λ6584/H α ‘Baldwin, Phillips & Terlevich’ (BPT) diagram using a sample of local analogues of high-redshift galaxies. These high-redshift analogue galaxies are selected from the Sloan Digital Sky Survey. Located in the same region on the BPT diagram as the ultraviolet selected galaxies at z ∼ 2, these high-redshift analogue galaxies provide an ideal local benchmark to study the offset between the local and high-redshift galaxies on the BPT diagram. We compare the nitrogen-to-oxygen ratio (N/O), the shape of the ionizing radiation field, and ionization parameters between the high-redshift analogues and a sample of local reference galaxies. The higher ionization parameter in the high-redshift analogues is the dominant physical mechanism driving the BPT offset from low- to high-redshift, particularly at high [N ii] λ6584/H α. Furthermore, the N/O ratio enhancement also plays a minor role to cause the BPT offset. However, the shape of the ionizing radiation field is unlikely to cause the BPT offset because the high-redshift analogues have a similar hard ionizing radiation field as local reference galaxies. This hard radiation field cannot be produced by the current standard stellar synthesis models. The stellar rotation and binarity may help solve the discrepancy.
Population synthesis of exocometary gas around A stars
Authors: Marino S , Flock M , Henning Th , Kral Q , Matrà L , Wyatt M C 
Published: January 2020

ABSTRACT
The presence of CO gas around 10–50 Myr old A stars with debris discs has sparked debate on whether the gas is primordial or secondary. Since secondary gas released from planetesimals is poor in H2, it was thought that CO would quickly photodissociate never reaching the high levels observed around the majority of A stars with bright debris discs. Kral et al. showed that neutral carbon produced by CO photodissociation can effectively shield CO and potentially explain the high CO masses around 9 A stars with bright debris discs. Here, we present a new model that simulates the gas viscous evolution, accounting for carbon shielding and how the gas release rate decreases with time as the planetesimal disc loses mass. We find that the present gas mass in a system is highly dependant on its evolutionary path. Since gas is lost on long time-scales, it can retain a memory of the initial disc mass. Moreover, we find that gas levels can be out of equilibrium and quickly evolving from a shielded on to an unshielded state. With this model, we build the first population synthesis of gas around A stars, which we use to constrain the disc viscosity. We find a good match with a high viscosity (α ∼ 0.1), indicating that gas is lost on time-scales ∼1–10 Myr. Moreover, our model also shows that high CO masses are not expected around FGK stars since their planetesimal discs are born with lower masses, explaining why shielded discs are only found around A stars. Finally, we hypothesize that the observed carbon cavities could be due to radiation pressure or accreting planets.
Rhizotaxis Modulation in Arabidopsis Is Induced by Diffusible Compounds Produced during the Cocultivation of Arabidopsis and the Endophytic Fungus Serendipita indica
Authors: Inaji Aoi , Okazawa Atsushi , Taguchi Taiki , Nakamoto Masatoshi , Katsuyama Nao , Yoshikawa Ryoka , Ohnishi Toshiyuki , Waller Frank , Ohta Daisaku 
Published: January 2020

AbstractRhizotaxis is established under changing environmental conditions via periodic priming of lateral root (LR) initiation at the root tips and adaptive LR formation along the primary root (PR). In contrast to the adaptable LR formation in response to nutrient availability, there is little information on root development during interactions with beneficial microbes. The Arabidopsis root system is characteristically modified upon colonization by the root endophytic fungus Serendipita indica, accompanied by a marked stimulation of LR formation and the inhibition of PR growth. This root system modification has been attributed to endophyte-derived indole-3-acetic acid (IAA). However, it has yet to be clearly explained how fungal IAA affects the intrinsic LR formation process. In this study, we show that diffusible compounds (chemical signals) other than IAA are present in the coculture medium of Arabidopsis and S. indica and induce auxin-responsive DR5::GUS expression in specific sections within the pericycle layer. The DR5::GUS expression was independent of polar auxin transport and the major IAA biosynthetic pathways, implicating unidentified mechanisms responsible for the auxin response and LR formation. Detailed metabolite analysis revealed the presence of multiple compounds that induce local auxin responses and LR formation. We found that benzoic acid (BA) cooperatively acted with exogenous IAA to generate a local auxin response in the pericycle layer, suggesting that BA is one of the chemical signals involved in adaptable LR formation. Identification and characterization of the chemical signals will contribute to a greater understanding of the molecular mechanisms underlying adaptable root development and to unconventional technologies for sustainable agriculture.
Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica
Authors: Nakajima Shihoko , Chiba Asako , Makiyama Ayako , Hayashi Eri , Murayama Goh , Yamaji Ken , Kobayashi Shigeto , Tamura Naoto , Takasaki Yoshinari , Miyake Sachiko 
Published: January 2020

Abstract

Objectives
Although T cells are thought to be involved in the pathogenesis of PMR, whether innate-like T cells are involved in the process remains unknown.

Methods
The serum levels of 27 cytokines/chemokines in patients with PMR were measured by a multiplex immunoassay (Bio-Plex Assay). The cytokine-producing capacity of T and innate-like T cells was assessed by intracellular cytokine staining and flow cytometry. The frequency and activated status of T and innate-like T cells were investigated by flow cytometry and their associations with clinical parameters were assessed.

Results
The levels of inflammatory cytokines were associated with disease activity in PMR. The cytokine-producing capacity by CD8+ T and innate-like T cells was associated with disease activity. The frequency of HLA-DR+ CD38+ cells among CD8+ T cells was increased in patients with active disease. The frequencies of HLA-DR+ CD38+ cells among CD4+ T, mucosal-associated invariant T (MAIT) and γδ T cells were higher in patients with inactive disease. The frequency of HLA-DR+ CD38+ MAIT cells was associated with the PMR activity score and CRP levels in patients in remission.

Conclusion
The inflammatory cytokine-producing capacity and expression of activation markers of CD8+ T and innate-like T cells were associated with the disease activity of PMR. MAIT cell activation in patients in remission may contribute to the subclinical activity of the disease.
Risk factors for severe cranial ischaemic complications in giant cell arteritis
Authors: Hočevar Alojzija , Ješe Rok , Tomšič Matija , Rotar Žiga 
Published: January 2020

Abstract

Objectives
Vision complications and a stroke represent severe cranial ischaemic complications (sCIC) associated with increased morbidity and mortality in GCA. We aimed to determine the risk factors for sCIC in GCA.

Methods
We analysed the medical records of prospectively enrolled GCA patients diagnosed between September 2011 and August 2019, and compared the clinical and laboratory characteristics of patients with and without sCIC defined as either severe vision complications (diplopia, transient vision loss, permanent partial vision field/acuity defect and permanent visual loss) or stroke.

Results
During the 96-month observation period, we identified 295 new GCA patients [65.4% female, median (interquartile range) age 74.7 (67.3–80.0) years]. Sixty-one (20.7%) patients developed sCIC (52 isolated severe vision complications, 5 isolated ischaemic strokes and 4 patients with both complications). In a multivariable logistic regression model jaw claudication [odds ratio (OR) 3.43 (95% CI: 1.84, 6.42), P &lt; 0.001], smoking [OR 1.92 (95% CI: 1.01, 3.65), P = 0.046] and increasing age [OR 1.08 (95% CI: 1.04, 1.13), P &lt; 0.001] were significantly associated with sCIC. Higher CRP [OR 0.99 (0.99–1.00), P = 0.011] decreased the risk of sCIC. When considered separately, the odds for severe vision complications increased with age and jaw claudication, and decreased with polymyalgia rheumatica, constitutional symptoms and higher CRP. Atrial fibrillation emerged as the sole independent predictor of ischaemic stroke.

Conclusion
Increasing age, jaw claudication and smoking predicted sCIC, while higher CRP decreased the risk of sCIC in our GCA cohort.
Diagnosis of fibromyalgia: comparison of the 2011/2016 ACR and AAPT criteria and validation of the modified Fibromyalgia Assessment Status
Authors: Salaffi Fausto , Di Carlo Marco , Farah Sonia , Atzeni Fabiola , Buskila Dan , Ablin Jacob N , Häuser Winfried , Sarzi-Puttini Piercarlo 
Published: January 2020

Abstract

Objective
To compare the concordance of the three diagnostic criteria, respectively the 2011 ACR criteria (ACR 2011 Cr), the ACR 2016 criteria (ACR 2016 Cr) and the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION)-APS Pain Taxonomy criteria (AAPT Cr), and to explore the performance of an additional set of criteria, the modified Fibromyalgia Assessment Status (FAS 2019 modCr), in the diagnosis of FM syndrome.

Methods
Consecutive patients with chronic widespread pain, referred by the primary care setting, underwent rheumatologic assessment that established the presence or not of FM and were investigated through the four sets of proposed criteria. For the FAS 2019 modCr, discriminant validity to distinguish patients with FM and non-FM was assessed with receiver operating characteristic curve analysis.

Results
A total of 732 (405 with FM and 327 with other common chronic pain problems) patients were evaluated. Against the clinical diagnosis of FM, the sensitivity, specificity and correct classification were, respectively: 79.8, 91.7 and 85.1% for ACR 2011 Cr; 78, 90.5 and 83.6% for the ACR 2016 Cr; and 73.8, 91.7 and 81.8% for the AAPT Cr. The alternative set, proposed on the FAS 2019 modCr, provided a maximal diagnostic accuracy with a score ≥20 (Youden’s index), with a sensitivity of 84.2%, specificity 89.0% and positive likelihood ratio 7.65.

Conclusion
There is a considerable agreement between criteria-based diagnoses of FM, although the AAPT Cr perform least well in terms of percentage of correct classification. The FAS 2019 modCr had comparable characteristics.
An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action
Authors: Kondo Miwa , Kikumoto Hiroko , Osimitz Thomas G , Cohen Samuel M , Lake Brian G , Yamada Tomoya 
Published: January 2020

Abstract
In 2-year studies, the nongenotoxic pyrethroid insecticide permethrin produced hepatocellular tumors in CD-1 mice but not in Wistar rats. Recently, we demonstrated that the mode of action (MOA) for mouse liver tumor formation by permethrin involves activation of the peroxisome proliferator-activated receptor alpha (PPARα), resulting in a mitogenic effect. In the present study, the effects of permethrin and 2 major permethrin metabolites, namely 3-phenoxybenzoic acid and trans-dichlorochrysanthemic acid, on cytochrome P450 mRNA levels and cell proliferation (determined as replicative DNA synthesis) were evaluated in cultured CD-1 mouse, Wistar rat, and human hepatocytes. Permethrin and 3-phenoxybenzoic acid induced CYP4A mRNA levels in both mouse and human hepatocytes, with trans-dichlorochrysanthemic acid also increasing CYP4A mRNA levels in mouse hepatocytes. 3-Phenoxybenzoic acid induced CYP4A mRNA levels in rat hepatocytes, with trans-dichlorochrysanthemic acid increasing both CYP4A mRNA levels and replicative DNA synthesis. Permethrin, 3-phenoxybenzoic acid, and trans-dichlorochrysanthemic acid stimulated replicative DNA synthesis in mouse hepatocytes but not in human hepatocytes, demonstrating that human hepatocytes are refractory to the mitogenic effects of permethrin and these 2 metabolites. Thus, although some of the key (eg, PPARα activation) and associative (eg, CYP4A induction) events in the established MOA for permethrin-induced mouse liver tumor formation could occur in human hepatocytes at high doses of permethrin, 3-phenoxybenzoic acid, and/or trans-dichlorochrysanthemic acid, increased cell proliferation (an essential step in carcinogenesis by nongenotoxic PPARα activators) was not observed. These results provide additional evidence that the established MOA for permethrin-induced mouse liver tumor formation is not plausible for humans.
Empiric use of oxygen for acute atraumatic, unilateral, retro-orbital headaches
Authors: Perez Daniel J. 
Published: January 2020

ABSTRACT
This article describes a man who presented with a 2-week history of atraumatic, unilateral, retro-orbital cranio-facial pain, ipsilateral diaphoresis, and facial flushing. He was diagnosed with cluster headaches after a positive response to oxygen therapy. Early consideration for oxygen therapy in the acute setting should be considered in all patients with an acute, unilateral, retro-orbital headache.
Addressing religious objections to vaccination
Authors: Clemens Jonathan 
Published: January 2020

ABSTRACT
Religious objections to vaccines are in the news, but clinician engagement with patients' underlying religious objections has been minimal, presumably because clinicians lack tools to respectfully address these objections while honoring patient autonomy. This article introduces a four-step framework for exploring and responding to a patient's stated religious objections to vaccination, culminating in suggested approaches for respectful and collaborative discussions to encourage optimum patient protection consistent with informed consent and patient belief systems. Three hypothetical situations are presented and evaluated.
Drug-induced proarrhythmia
Authors: Klotzbaugh Ralph J. , Martin Alejandra , Turner J. Rick 
Published: January 2020

ABSTRACT
Clinical practice includes contributions from physicians, pharmacists, NPs, and physician assistants. Drug safety considerations are of considerable importance. This article discusses drug-induced proarrhythmia, with a specific focus on torsades de pointes, a polymorphic ventricular tachycardia that typically occurs in self-limiting bursts that can lead to dizziness, palpitations, syncope, and seizures, but on rare occasions can progress to ventricular fibrillation and sudden cardiac death. A dedicated clinical pharmacology study conducted during a drug's clinical development program has assessed its propensity to induce torsades using prolongation of the QT interval as seen on the ECG as a biomarker.
Identification of QT-interval prolongation does not necessarily prevent a drug from receiving marketing approval if its overall benefit-risk balance is favorable, but, if approved, a warning is placed in its prescribing information. This article explains why drugs can have a proarrhythmic propensity.
Efficacy and Safety of Tapentadol Immediate Release for Acute Pain
Authors: Wang Xinyi , Narayan Sujita W. , Penm Jonathan , Patanwala Asad E. 
Published: January 2020

Objective:
Tapentadol (TAP) immediate release (IR) is a newer opioid option for acute pain. The aim of this systematic review was to examine the efficacy and safety of TAP IR compared with other opioids for acute pain.

Methods:
A systematic literature search as conducted using the Cochrane Library, Embase, International Pharmaceutical Abstracts, MEDLINE, PubMed, and Web of Science. The search included all randomized controlled trials and observational studies examining TAP IR versus other orally administered IR opioids for acute pain. The protocol for this study was registered on PROSPERO (CRD42018110267).

Results:
Thirteen studies and 1 abstract were included in the systematic review (n=12,814 patients). Of these, 5 studies and 1 abstract were included in the qualitative review (n=9108 patients). Eight randomized controlled trials (n=3706 patients) comparing 50 to 100 mg TAP IR versus 5 to 15 mg oxycodone IR were included in the meta-analysis. The lowest dose of TAP IR (ie, 50 mg) was associated with less pain control compared with oxycodone IR (standardized mean difference=0.25, 95% confidence interval: 0.06-0.44, P<0.01). However, there were no significant differences at higher doses (ie, 75, 100 mg, or when a titration strategy was used). In the qualitative analysis, pain control with TAP IR was also similar to morphine IR and tramadol IR. TAP IR was less likely to have gastrointestinal adverse effects such as nausea and constipation compared with other opioids.

Discussion:
TAP IR is as effective as other opioids at higher doses for acute pain and is associated with fewer gastrointestinal adverse effects. On the basis of these findings, TAP IR can be considered as a first-line opioid for acute pain.
Influence of NICU Nurse Education on Intention to Support Lactation Using Tailored Techniques
Authors: Blatz Mary Ann , Huston Amy J. , Anthony Mary K. 
Published: January 2020

Background:
Preterm infants' outcomes improve when fed their mothers' milk. Low percentages of neonatal intensive care unit (NICU) nurses support mothers facing barriers to establishing and sustaining adequate milk supplies. Nurses' motivations and attitudes are instrumental, but understudied, factors in their intention to promote maternal lactation.

Purpose:
Using the Theory of Reasoned Action, this study explored (1) NICU nurses' attitudes, social pressures, feelings of preparedness, perceptions of comfort, and intention to support lactation; and (2) magnitude of relationships among these concepts before and after undertaking an educational module.

Methods:
A descriptive pre-/postintervention design included a sample of 24 NICU nurses who completed a module, including general lactation and hands-on expressing information. The Nursing Support for Breastfeeding Questionnaire was administered before and after completing the module.

Results:
Attitudes, social norms, perception of preparedness, and intention were moderate to high before and after completion of the module. Perception of comfort was moderate. When comparing pre- and postintervention, effect sizes for intention and perception of comfort were moderate. Magnitude of the relationship between attitudes and intention was strong before intervention and moderate after intervention. Subjective norms demonstrated stronger relationships with attitudes and intention after intervention. Preparedness and comfort had stronger relationships with attitudes than with intention both before and after intervention.

Implications for Practice:
Nurses' attitudes, perception of preparedness, and comfort are modifiable considerations in developing strategies to support evidence-based lactation techniques.

Implications for Research:
Additional studies are needed with fully powered and stronger designs to validate findings to guide interventions for nurse support for NICU mothers to optimize lactation.
The accuracy of central blood pressure obtained by oscillometric noninvasive method using Mobil-O-Graph in children and adolescents
Authors: Shiraishi Masahiro , Murakami Tomoaki , Higashi Kouji 
Published: January 2020

Objectives:
Central blood pressure (CBP) can now be reliably measured noninvasively with a number of devices in adult; however, noninvasive assessment of CBP has not been validated in children and adolescents. The purpose of this study was to clarify the accuracy of noninvasive oscillometric CBP measurements in children and adolescents.

Methods:
This study included 60 patients with an average age of 7.9 ± 4.4 years (range 1–18 years) who underwent a cardiac catheterization. We compared CBP, estimated with a noninvasive oscillometric method using a Mobil-O-Graph, with simultaneous invasive recordings using a catheter in children and adolescents.

Results:
Comparison of the SBP values measured by the two methods, showing a linear correlation (r = 0.85; P < 0.0001) with the mean difference aortic SBP minus estimated central SBP of 2.0 ± 5.6 mmHg (95% limits of agreement = −9.0–13.1). In DBP values, there was a correlation (r = 0.72; P < 0.0001) with the mean difference aortic DBP minus estimated central DBP of −0.1 ± 6.4 mmHg (95% limits of agreement = −12.6–12.4). Sex and cardiac function did not affect central SBP estimation; however, the correlation between aortic and estimated central SBP in adolescents was better than that in children (r = 0.93, P < 0.0001 vs. r = 0.77, P < 0.0001), though the difference was not statistically significant (P = 0.483).

Conclusion:
Estimated CBP using Mobil-O-Graph in children and adolescents shows a certain degree of accuracy, which will be helpful in future for evaluating CBP in children and adolescents.
INTERMEDIATE UVEITIS WITH RETINAL DETACHMENT IN A PATIENT WITH POMPE DISEASE
Authors: Thomas Akshay S. , Grewal Dilraj S. , Toth Cynthia A. 
Published: January 2020

Purpose:
To describe the ocular findings in a patient with glycogen storage disease II (Pompe disease).

Methods:
Case report.

Results:
A 14-year-old boy with Pompe disease was referred for evaluation of a retinal detachment in the left eye. Indirect ophthalmoscopy revealed bilateral fibrotic snowbanks and an inferior rhegmatogenous retinal detachment extending into the macula. Fluorescein angiography revealed mild diffuse perivascular leakage in both eyes. The retinal detachment was repaired with scleral buckling and cryotherapy. Workup for the etiology of the intermediate uveitis was unrevealing.

Conclusion:
Enzyme replacement therapy has improved the survival of individuals with Pompe disease. With greater patient longevity, new ocular associations may continue to emerge. Whether intermediate uveitis is an ocular association of Pompe disease remains to be determined.