bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic risk attributes in Malaysia stock markets: Behavioural finance insights
Authors: Tuyon Jasman , Ahmad Zamri 
Published: August 2020

AbstractThis paper proposes a quasi‐rational multi‐factor stock‐pricing determinants model with fundamental (rational) and behavioural (irrational) risk factors that highlight academic and practical merits. Academically, this study provides proofs to the notion of bounded rational and dynamic risk–return relationships. Practically, ways to uncover dynamics risk attributes in equity markets are highlighted. The empirical tests are performed based on a sample of 238 Malaysian firm stock returns with monthly data spanning from 1996:01 to 2014:12. The panel regression and quantile panel regression methods are employed in estimations to uncover the dynamic risk–return relationships. Collectively, the analyses provide evidence to support the dynamic of risk attributes due to quasi‐rational risk factors and given different prospects namely; firm characteristics, market states, as well as losses and gains. In theory, the results lend support to the validity of the suggested stock‐pricing determinants model. In practice, the study provides valuable insights to capture multi‐attributes risk dynamics in stock market that will benefits practitioners for trading strategies and policymakers for market efficiency governance policymaking.
Integration of the Baltic stock markets with developed European markets
Authors: Harkmann Kersti 
Published: August 2020

AbstractThis paper examines the extent of integration of the Baltic stock markets with the financial markets in Western Europe. The long‐run relationships between the stock markets of the Baltic States and selected developed stock markets are studied by means of cointegration analysis on the weekly returns. For the Baltic stock markets and key indices from the European markets, the empirical results over period 2005–2015 provide clear evidence that the Baltic stock markets are integrated with the Swedish stock market, and that this cointegrating relationship implies transmission of shocks from Sweden to the Baltic States. The cointegration analysis is also conducted for rolling windows over consequent sub‐samples, which only verifies the robustness of the integration between the stock markets of the Baltic States and Sweden. Given that there is no support for the long‐term relationships between the Baltic market and euro area, it may be that Baltic markets offer diversification benefits for the euro area indices.
Bubble tests in the London housing market: A borough level analysis
Authors: Petris Panagiotis , Dotsis George , Alexakis Panayotis 
Published: August 2020

AbstractIn this study, we apply a recursive right‐tailed test to investigate for evidence of “bubbles” in the London housing market. We implement the test using data from all London boroughs. Aggregate tests indicate long periods of explosive behaviour of housing prices in the London residential market. Applying the test at a regional level, we identify house price booms in five boroughs, and we detect bubbles in only three, out of the total 32 London boroughs. The test finds no‐bubble condition in the inner London boroughs, even in the Prime Central London areas, where the highest house prices have been recorded.
Innovation—Unemployment Nexus: The case of EU countries
Authors: Yildirim Durmuş Çagri , Yildirim Seda , Erdogan Seyfettin , Kantarci Tugba 
Published: August 2020

AbstractIn order to achieve a sustainable growth and development process in a globalised competitive environment, the effect of monitoring the technological developments of the national economies is a necessity. Innovation, shown as a cause of technological developments, contributes to the transformation of technology into social and economic benefits. Innovation changes the structure of employment. However, there is no consensus in the literature about how innovation affects employment. Some suggest that technological innovations will lead to an increase in unemployment as a result of the substitution of machines instead of labour. The others state that technological innovations can improve the working life and create a reducing effect of unemployment as a result of every technological innovation creating their own fields of work. The aim of this study is to examine the effects of innovation on unemployment. The data of 12 EU countries with high and relatively low level of innovation were analysed with the panel threshold model for the period of 1998–2015. Innovation in high and low regimes, has effects that will increase unemployment. Technological development increases the unemployment rate in both country groups in both regimes of innovation level.
Inhibition of microRNA‐9‐5p and microRNA‐128‐3p can inhibit ischemic stroke‐related cell death in vitro and in vivo
Authors: Yan Qi , Sun Shou‐yuan , Yuan Shuai , Wang Xiao‐qing , Zhang Zhen‐chang 
Published: August 2020

AbstractIschemic stroke is the major form of stroke and is accentuated by multiple comorbidities. It has been previously shown that different microRNAs (miRNAs) regulate separate aspects of ischemic stroke. Differential miRNA expression analysis in cerebrospinal fluid of stroke patients had revealed upregulation of miR‐124‐3p, miR‐9‐3p, miR‐9‐5p, and miR‐128‐3p. However, whether the overexpression is correlative or causative was not known. Here, using an in vitro oxygen–glucose deprivation/reoxygenation (OGD/R) neuronal cell model, we saw OGD/R‐induced injury was associated with significant upregulation of the aforementioned four miRNAs. Target gene prediction using in situ algorithms and gene set enrichment analysis revealed significant enrichment of FOXO and Relaxin signaling pathways and regulatory processes associated with endothelial cell migration, which are all known to associate with apoptotic pathways. In situ protein–protein interaction network analysis confirmed the findings of gene set enrichment analysis. TUNEL analysis showed that OGD/R‐induced injury resulted in significant apoptosis, which was significantly inhibited in neuronal cells pretransfected with inhibitors of either miR‐9‐5p or miR‐128‐3p. Further testing in an in vivo middle cerebral artery occlusion (MCAO) mouse model of ischemic stroke showed that inhibiting miR‐9‐5p or miR‐128‐3p significantly decreases MCAO‐induced infraction volume and inhibited apoptotic response as revealed by decreased cleaved Caspase‐3 protein expression in immunohistochemical analysis. Combined inhibition of miR‐9‐5p and miR‐128‐3p resulted in a synergistic decrease in cell death and infraction volume in vitro and in vivo, respectively. Cumulatively, our results provide critical knowledge about the mechanism by which elevated miR‐9‐5p and miR‐128‐3p causes brain damage in ischemic stroke and provides evidence of them being attractive therapeutic targets.
Does drawing down the US Strategic Petroleum Reserve help stabilize oil prices?
Authors: Kilian Lutz , Zhou Xiaoqing 
Published: August 2020

SummaryWe study the effects of releases from the US Strategic Petroleum Reserve (SPR) within the context of fully specified models of the global oil market that explicitly allow for storage demand as well as unanticipated changes in the SPR. We show that historically SPR policy interventions, defined as sequences of exogenous SPR shocks during selected periods, have helped stabilize the price of oil. Their effect on the price of oil, however, has been modest. For example, the cumulative effect of the SPR releases after the invasion of Kuwait in 1990 was a reduction of $2 per barrel in the real price of oil after 7 months. Whereas emergency drawdowns tend to lower the real price of oil, we find that exchanges tend to raise the real price of oil in the long run. We also provide a detailed analysis of the benefits of the 2018 White House proposal to sell off half of the SPR within the next decade. We show that the expected fiscal benefits of this plan are somewhat higher than the revenue of $16.6 billion dollars projected by the White House.
Guided filter based image enhancement for focal error compensation in low cost automated histopathology microscopic system
Authors: Awasthi Navchetan , Katare Prateek , Gorthi Sai Siva , Yalavarthy Phaneendra K. 
Published: August 2020

AbstractLow‐cost automated histopathology microscopy systems usually suffer from optical imperfections, producing images that are slightly Out of Focus (OoF). In this work, a guided filter (GF) based image preprocessing is proposed for compensating focal errors and its efficacy is demonstrated on images of healthy and malaria infected red blood cells (h‐RBCs and i‐RBCs), and PAP smears. Since contrast enhancement has been widely used as an image preprocessing step for the analysis of histopathology images, a systematic comparison is made with six such prominently used methods, namely Contrast Limited Adaptive Histogram Equalization (CLAHE), RIQMC‐based optimal histogram matching (ROHIM), modified L0, Morphological Varying(MV)‐Bitonic filter, unsharp mask filter and joint bilateral filter. The images enhanced using GF approach lead to better segmentation accuracy (upto 50% improvement over native images) and visual quality compared to other approaches, without any change in the color tones. Thus, the proposed GF approach is a viable solution for rectifying the OoF microscopy images without the loss of the valuable diagnostic information presented by the color tone.
Polycaprolactone fumarate acts as an artificial neural network to promote the biological behavior of neural stem cells
Authors: Vafaei Atefeh , Rahbarghazi Reza , Kharaziha Mahshid , Avval Negar Abbasi , Rezabakhsh Aysa , Karimipour Mohammad 
Published: August 2020

AbstractHerein, we investigated the effect of electrospun polycaprolactone fumarate (PCLF) nanofibers on neural stem cell (NSC) behavior in the in vitro setting. Murine NSCs were isolated from adult mice subventricular zone and immunophenotyped by flow cytometry assay and immunofluorescence staining. Cells were cultured on the plastic surface, laminin‐coated surface, and electrospun PCLF nanofibers. Cell morphology, attachment, and spreading were evaluated by scanning electron microscopy analysis. Cell viability and proliferation rates were evaluated by MTT assay. The proliferation of plated cells was investigated by monitoring Ki‐67‐positive cells using flow cytometry analysis. The protein levels of Map‐2 and GFAP were detected by using immunofluorescence staining to show neural and astrocyte differentiation capacity. Scanning electron microscopy images revealed an extensive distribution, morphological adaptation, and cell‐to‐cell connectivity in NSCs upon culture on the PCLF surface. MTT analysis showed that the NSCs had more survival rates on the PCLF surface compared to the laminin and control groups over time (p < 0.05). In contrast to the laminin group, Ki‐67 analysis showed a decrease of proliferating cells in the PCLF group. Immunofluorescence staining revealed the prominent increase of Map‐2 and GFAP reduction in NSCs from the PCLF group compared to the laminin and control groups, showing the stimulatory effect of PCLF on targeted maturation of NSCs (p < 0.05). In brief, PCLF based construct promotes NSCs morphological adaptation and neuronal differentiation, suggesting PCLF as an appropriate and applicable substrate in neural tissue engineering.
Retrospective comparison between COBE SPECTRA and SPECTRA OPTIA apheresis systems for hematopoietic progenitor cells collection for autologous and allogeneic transplantation in a single center
Authors: López‐Pereira Patricia , Sola Aparicio Elena , Vicuña Andrés Isabel , Cámara Montejano Carmen , Muñoz Calleja Cecilia , Alegre Amor Adrián , Aguado Bueno Beatriz 
Published: August 2020

AbstractIntroductionCOBE SPECTRA [COBE] (Terumo, BCT Lakewood CO) apheresis system has been the most used device for hematopoietic progenitor cells (HPC) collection. Recently, it has been replaced by the SPECTRA OPTIA [OPTIA] (Terumo, BCT Lakewood CO) apheresis system. The aim of our study is to compare both methods for HPC collection.Material and methodsWe retrospectively compared 302 HPC collection apheresis procedures (115 allogeneic donors and 187 autologous). The study cohort was divided according to the apheresis system used to analyze the differences between COBE and OPTIA, specifically efficacy of apheresis procedure and product characteristics.ResultsOPTIA collections result in a higher CD34+ collection efficiency in both groups (autologous 45.3% vs 41%, P < .006; allogeneic 54.9% vs 45%, P < .0001). The total of CD34+ cells ×106 /kg recipient collected in the product were comparable in both groups (autologous 2.9 in OPTIA group vs 2.8 in COBE group, P = .344; allogeneic 6.2 in OPTIA group vs 5.8 in COBE group, P = .186). The percentage of platelet loss in autologous donors was significantly lower (35.7% vs 40.8%, P < .01). Regarding quality of the product, we observed a significantly lower hematocrit in products collected with OPTIA in both groups (1.8% vs 4%, P < .0001) as well as significantly lower amount of leukocytes (median 153.4 vs 237.2 × 109/L in autologous, P < .0001; 239.5 vs 340.2 × 109/L in allogeneic P < .0001).ConclusionBoth apheresis systems are comparable in collection of hematopoietic progenitor cells, with significantly higher collection efficiency with the OPTIA system. Collection products obtained with OPTIA contain significantly lower hematocrit and leukocytes.
The lncRNA SNHG15/miR‐18a‐5p axis promotes cell proliferation in ovarian cancer through activating Akt/mTOR signaling pathway
Authors: Zhang Jingru , Wang Ling , Jiang Jing , Qiao Zhiwei 
Published: August 2020

AbstractHere, we report the expression pattern, function and regulatory mechanism of SNHG15 together with miR‐18a‐5p micro RNA in ovarian cancer (OC) for the first time. We recruited 20 patients and took normal ovarian tissues and ovarian tumor tissues from them. We used cell culture, transfection, in vivo tumor xenograft assay, and multiple types of detection assays to investigate the expression and regulation of long noncoding RNA (lncRNA) SNHG15/miR‐18a‐5p in ovarian tissues and cells. Results: We found that the messenger RNA expression level of SNHG15 was significantly higher and miR‐18 was decreased in ovarian cancer tissues and in OC cells. Functional experiments showed that SNHG15 overexpression potentiated the migration and invasion of OC cells, while SNHG15 inhibition reduced the tumor proliferation, which was restored via overexpression of miR‐18a. SNHG15 was found to directly target and suppress the expression of miR‐18a. Our results illustrate the possible molecular mechanism of lncRNA SNHG15/miR‐18a‐5p functions in cell proliferation in OC. SNHG15/miR‐18a promoted the progression of OC cells via the protein kinase B/mammalian target of rapamycin signaling pathway.
Accurate prediction of norbornadiene cycle enthalpies by DLPNO‐CCSD(T1)/CBS method
Authors: Dorofeeva Olga V. 
Published: August 2020

AbstractThe DLPNO‐CCSD(T1)/CBS method combined with simple reactions containing small reference species leads to an improvement in the accuracy of theoretically evaluated enthalpies of formation of medium‐sized polyalicyclic hydrocarbons when compared with the widely used composite approach. The efficiency of the DLPNO‐CCSD(T1)/CBS method is most vividly demonstrated by comparing with the results of G4 calculations for adamantane. The most important factor in choosing appropriate working reaction is the same number of species on both sides of the equation. Among these reactions, the reactions with small enthalpy change usually provide a better cancellation of errors. The DLPNO‐CCSD(T1)/CBS method was used to calculate the enthalpies of formation of compounds belonging to the norbornadiene cycle (norbornadiene, quadricyclane, norbornene, nortricyclane, and norbornane). The most reliable experimental enthalpies of formation are recommended for these compounds by comparing calculated values with conflicting experimental data.
Comparison of double antigen sandwich and indirect enzyme‐linked immunosorbent assay for the diagnosis of hepatitis C virus antibodies
Authors: Qin Ya‐Juan , Sha Ruo‐cheng , Feng Yang‐Chun , Huang Yan‐Chun 
Published: August 2020

AbstractBackgroundThe aim of this study is to compare double‐antigen sandwich enzyme‐linked immunosorbent assay (ELISA) and indirect ELISA in the diagnosis of hepatitis C virus（HCV）infection.Methods and materialsA total of 176 samples from the Tumor Hospital Affiliated to Xin Jiang Medical University were utilized to comparison. All serum samples were tested using double‐antigen sandwich ELISA and indirect ELISA. Cohen's kappa statistics were used to assess the agreement between the two assays, and multivariate analysis was used to evaluate risk factors for the discordance between the double‐antigen ELISA and indirect ELISA.ResultsThe positivities of indirect ELISA (Beijing Wantai), double‐antigen sandwich ELISA (Beijing Wantai), and indirect ELISA (Beijing Jinhao) were 74.43%, 68.75%, and 73.30%, respectively. The agreement between the indirect ELISA (Beijing Wantai) and double‐antigen sandwich ELISA (Beijing Wantai) was high (κ = 0.829;P < .001), and the agreement between the double‐antigen sandwich ELISA (Beijing Wantai) and indirect ELISA (Beijing Jinhao) was high (κ = 0.847;P < .001). Variables associated with discordant results between the double‐antigen sandwich and indirect ELISA in multivariate analysis were as follows: female (OR:1.462; P < .05), age (<35 years old; OR:3.667; P < .05), and cancer (suffer from malignant tumor; OR:3.621; P < .05).ConclusionIn detection of HCV, high agreement was found between the double‐antigen sandwich ELISA and indirect ELISA. Female, younger age, and suffer from malignant tumor were significant risk factors for the discordance. Based on double‐antigen sandwich ELISA has distinct methodological advantages over indirect ELISA. It is recommended for the diagnosis of HCV infection.
Serotypes, antibiotic resistance, and virulence genes of Salmonella in children with diarrhea
Authors: Yue Meina , Li Xiaoyu , Liu Di , Hu Xue 
Published: August 2020

AbstractBackgroundSalmonella is an important foodborne pathogen that causes acute diarrhea in humans worldwide. This study analyzed the relationships of serotypes and antibiotic resistance with virulence genes of Salmonella isolated from children with salmonellosis.MethodsSerological typing was performed using the slide‐agglutination method. The Kirby‐Bauer disk diffusion method was used to test antibiotic susceptibility. Twenty virulence genes were detected by PCR.ResultsSalmonella Typhimurium (21 isolates, 34.43%) and S Enteritidis (12 isolates, 19.67%) were the predominant species among the 61 isolates. Ampicillin resistance was most common (63.93%), and among the cephalosporins, resistance was most often found to cefotaxime, a third‐generation cephalosporin (19.67%). Among the 20 virulence genes, prgH, ssrB, and pagC were detected in all Salmonella isolates. In S Typhimurium, the detection rates of hilA, sipB, marT, mgtC, sopB, pagN, nlpI, bapA, oafA, and tolC were high. In S Enteritidis, the detection rates of icmF, spvB, spvR, and pefA were high. Nitrofurantoin resistance was negatively correlated with the virulence gene bapA (P = .005) and was positively correlated with icmF, spvB, spvR, and pefA (P = .012, .008, .002, and .005, respectively), The P values between all other virulence genes and antibiotic resistance were >.05.ConclusionSalmonella Typhimurium and S Enteritidis were the main serotypes in children with diarrhea in Hangzhou, China. Salmonella exhibited a high level of resistance to common antibiotics, and a high rate of bacteria carrying virulence genes was observed. However, no significant correlation was found between virulence genes and resistance to common antibiotics.
Dynamic‐relational treatment of perfectionism: An illustrative case study
Authors: Hewitt Paul L. , Mikail Samuel F. , Dang Silvain S. , Kealy David , Flett Gordon L. 
Published: August 2020

AbstractObjectivePerfectionism has been described as a multidimensional core vulnerability factor in various forms of dysfunction and disorders. Recently, we described our empirically supported‐dynamic‐relational treatment for perfectionism. This treatment integrates psychodynamic and interpersonal principles to reduce perfectionism and symptoms and enhance relationships with others and self by focusing on underlying relational patterns.MethodWe discuss this approach and present Azure, a 27‐year‐old woman who completed our group treatment and subsequent individual therapy as a follow‐up.ResultsAzure underwent a comprehensive psychological pretreatment assessment, the results of which were used to develop a working formulation that guided the group and individual psychotherapy. A description of the formulation and her experience in therapy are discussed and pre‐ and post‐treatment data illustrate changes in Azure's perfectionism and symptoms.ConclusionsWe discuss changes that occurred over the course of treatment.
Single exercise stress reduces central neurotrophins levels and adenosine A1 and A2 receptors expression, but does not revert opioid‐induced hyperalgesia in rats
Authors: Medeiros Liciane Fernandes , Nunes Éllen Almeida , Lopes Bettega Costa , de Souza Andressa , Cappellari Angélica Regina , de Freitas Joice Soares , de Macedo Isabel Cristina , Kuo Jonnsin , Cioato Stefania Giotti , Battastini Ana Maria de Oliveira , Caumo Wolnei , Torres Iraci L. S. 
Published: August 2020

AbstractBackgroundThis study assessed the effects of an acute stress model upon the long‐term hyperalgesia induced by repeated morphine administration in neonatal rats. We also evaluated neurotrophins and cytokines levels; expressions of adenosine and acetylcholine receptors, and acetylcholinesterase enzyme at the spinal cord.Material and methodsMale Wistar rats were subjected to morphine or saline administration from P8 to P14. Thermal hyperalgesia and mechanical hyperesthesia were assessed using the hot plate (HP) and von Frey (vF) tests, respectively, at postnatal day P30 and P60. After baseline measurements, rats were subjected to a single exercise session, as an acute stress model, at P30 or P60. We measured the levels of BDNF and NGF, interleukin‐6, and IL‐10 in the cerebral cortex and the brainstem; and the expression levels of adenosine and muscarinic receptors, as well as acetylcholinesterase (AChE) enzyme at the spinal cord.ResultsA stress exercise session was not able to revert the morphine‐induced hyperalgesia. The morphine and exercise association in rats induced a decrease in the neurotrophins brainstem levels, and A1, A2A, A2B receptors expression in the spinal cord, and an increase in the IL‐6 cortical levels. The exercise reduced M2 receptors expression in the spinal cord of naive rats, while morphine prevented this effect.ConclusionsSingle session of exercise does not revert hyperalgesia induced by morphine in rats; however, morphine plus exercise modulate neurotrophins, IL‐6 central levels, and expression of adenosine receptors.