bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic splenectomy after trauma
Authors: Fransvea Pietro , Costa Gianluca , Serao Angelo , Cortese Francesco , Balducci Genoveffa , Sganga Gabriele , Marini Pierluigi 
Published: October 2019

Importance:
A deep knowledge of the indication for laparoscopic splenectomy (LS) in trauma case can lead trauma surgeon to offer in a wider number of situations a minimally invasive approach to a common injuries.

Objective:
To present and review the advantages and disadvantages of laparoscopic approach for spleen trauma and to identify patient whose can benefit from a minimally invasive approach versus patient that need open surgery to assess the whole severity of trauma.

Evidence Review:
A systematic review was performed according to the PRISMA statement in order to identify articles reporting LS after trauma. A literature search was performed through MEDLINE (through PubMed), Embase and Google Scholar from January 1990 to December 2018. Studies conducted on animals were not considered. All other laparoscopic procedures for spleen trauma were excluded.

Results:
Nineteen articles were included in this study, reporting 212 LS after trauma. The most study includes blunt trauma patient. All LS were performed in haemodynamically stable patient. Post-operative complications were reported in all articles with a median post-operative morbidity rate of 30 patients (14.01%), including 16 (7.5%) post-operative deaths.

Conclusions and Relevance:
This article reports the feasibility and safety of a minimally invasive approach for common trauma injuries which can help non-advanced laparoscopic skill trauma surgeon to develop the best indication to when to adopt this kind of approach.
Late toxicities among laryngopharyngeal cancers patients treated with different schedules of concurrent chemoradiation at a rural tertiary cancer care center
Authors: Muttath Geetha , Vinin N.V. , Shringarpure Kalpita , Jones Joneetha , Balasubramanian Satheesan , Thavarool Sajithbabu , Ajaykumar Shilpa 
Published: October 2019

Abstract
Background: Concurrent chemoradiation is the treatment of choice for laryngeal-pharyngeal cancers. Apart from survival organ preservation remains major aims of the treatment. Advanced radiation techniques like VMAT have shown to reduce morbidity. The purpose of our study is to assess the late toxicities in patients treated with concurrent chemoradiation and its association with dose to organs at risk. Aims: Assessment of late toxicities following concurrent chemoradiation in patients with laryngopharyngeal cancers. Materials and Methods: Retrospective study at a tertiary cancer centre on patients with laryngeal and pharyngeal cancers treated with concurrent chemoradiation with VMAT upto a total dose of 69.3 -70 Gy in 33-35 fractions and concurrent chemotherapy with Cisplatin was done. Severe late toxicities and its association with demographic and clinical parameters and dose to OAR were studied. Data was analysed using EpiData analysis v2.2.2.182. Results: Of the 93 patients studied majority were males above 55 years. Oropharynx was the commonest site (58%) with T3 and N2 in majority. Late dysphagia and odynophagia was seen in 18(21%) and 23(27%) patients respectively. 16 (17%) had tube dependence and nine (9.6%) had aspiration pneumonia. D60, V50 and V60 along with site , node positivity and weight loss were found to be significantly associated with severe late toxicity. Conclusion: Oropharyngeal cancers, node positivity and weight loss were found to have significant grade III and above toxicities including tube dependency. Dose to larynx showed association with severe late toxicities, though dose to constrictors could not.
Performance of colposcopic scoring by modified International Federation of Cervical Pathology and Colposcopy terminology for diagnosing cervical intraepithelial neoplasia in a low-resource setting
Authors: Rema Prabhakaran Nair , Mathew Aleyamma , Thomas Shaji 
Published: October 2019

Abstract
Introduction: Colposcopy is a tool to evaluate women with cervical pre-cancer and cancer. To interpret the colposcopic findings, various scoring systems are used but with inter observer variations. To improve the quality of colposcopy, International Federation of Cervical Pathology and Colposcopy (IFCPC) has introduced a colposcopic nomenclature in 2011. Colposcopic scoring helps to select patients who need treatment for cervical intraepithelial neoplasia. Aim of the Study: The study aimed to evaluate the agreement between colposcopic diagnosis with the modified IFCPC terminology and cervical pathology in patients with abnormal screening tests and to assess the utility of this colposcopic scoring system in low resource settings. Methodology: Patients with abnormal screening tests who underwent colposcopic assessment in the department of Gynaecological oncology were included in the study. Colposcopic scoring was done by the modified IFCPC nomenclature. The results were compared with cytology and the final histopathology. Results: 56 patients were included in the study. The colposcopic scoring when compared to histopathology showed agreement in 65.7% which indicated the agreement was substantial and was statistically significant (P = 0.0001). With cytology the colposcopic score showed agreement in 35.6% indicating a fair agreement and this was also statistically significant (P = 0.001). Conclusion: Colposcopic scoring by modified IFCPC 2011 criteria showed substantial agreement with cervical histopathology. Compared to traditional methods, 2011 international terminology of colposcopy could improve colposcopic accuracy.
Barriers and explanatory mechanisms in diagnostic delay in four cancers – A health-care disparity?
Authors: Basu Abhishek , Ghosh Debjit , Mandal Bidyut , Mukherjee Pratyusha , Maji Avik 
Published: October 2019

Abstract
Introduction: Most cancer disparities research has traditionally focused on two key outcomes, access to appropriate treatment and survival, but they do not encompass important aspects of patient-centered care such as the timeliness of diagnosis and treatment. Prolonged time intervals between symptom onset and treatment initiation increase the risk of poorer clinical outcomes and are associated with worse patient experience of subsequent cancer care. This study aims to assess the delay from symptom onset to the start of definitive treatment and to identify the possible contributory factors and its impact on response in cancers of head and neck, breast, cervix, and lung. Materials and Methods: This was a retrospective study of patients enrolled between 2015 and 2017. A questionnaire was filled in about socioeconomic aspects, patient history, tumor data, professionals who evaluated the patients, and the respective time delays. Statistical test included Mann–Whitney U test, univariate and multivariate test, and one-way ANOVA to evaluate the correlations. Results: Stage migration was significant with patient delay (P < 0.01). In head and neck squamous cell carcinoma (HNSCC) and Carcinoma lung, a significant correlation was found between referral delay and residence (P < 0.01) and treatment delay and reason for referral (HNSCC only) (P = 0.04). Referral delay and treatment delay were correlated to response in breast and cervix, respectively (P < 0.01). Conclusion: Social awareness, regularly updating primary care physicians about alarming symptoms of cancer, developing guidelines to identify these symptoms, promoting continuity of care, and enabling access to specialist expertise through prompt referral should all help prevent delays in cancer diagnosis.
Cancer trends in Eastern India: Retrospective hospital-based cancer registry data analysis
Authors: Pandey Avinash , Raj Shraddha , Madhawi Richa , Devi Seema , Singh Rajesh Kumar 
Published: October 2019

Abstract
Background: Trends of cancer cases vary across several hospital-based cancer registries (HBCRs). There is a paucity of demographic data to evaluate trends of cancer in Eastern India. Aim: The aim of this study is to evaluate trends and pattern of cancer cases with respect to time from HBCR from Bihar. Objectives: The objective of this study is to evaluate the numbers of consecutive patients registered with eight most common type of cancer in our HBCR in Regional Cancer Centre, Bihar, and to evaluate trends of cancer cases registered with respect to time. Materials and Methods: Demographic profile of consecutive cancer patients registered from January 2014 to December 2016 (3 years) in HBCR was obtained. Patients diagnosed with common malignancies including head-and-neck cancer, gallbladder, breast, cervix, ovary, esophagus, stomach, hematolymphoid, and colorectal were analyzed. Frequency distribution, crosstabs, and line diagram were used to evaluate the trends of these common cancers with respect to time. Results: Sixty-six thousand and twenty-nine consecutive patients were registered between 2014 and 2016. Carcinoma gallbladder was the most common malignancy (21%), followed by head-and-neck cancer (19%) and breast cancer (15%). Median age at the diagnosis was 55 years for carcinoma gallbladder while 53 years and 46 years for head-and-neck and breast cancer, respectively. Male-to-female ratio was 0.6 for carcinoma gallbladder and 1.8 for head-and-neck cancer. A number of gallbladder and head-and-neck cancer registered increased by 36% (between 2014 and 2015) and 5% (between 2015 and 2016) and 24% (between 2014 and 2015) and 4% (between 2015 and 2016), respectively. Carcinoma breast and cervix showed decreasing trend with fall in registration up to 13% (between 2015 and 2016) and 27% (between 2015 and 2016), respectively. Conclusion: Carcinoma gallbladder is the most common cancer in Bihar. Head-and-neck cancer and carcinoma gallbladder are increasing while breast and cervical cancers are decreasing with respect to time.
A Meta-analysis on efficacy of auto fluorescence in detecting the early dysplastic changes of oral cavity
Authors: Chaitanya Nallan C.S.K , Chavva Sunanda , Surekha Elizabeth , Priyanka Vedula , Akhila Mule , Ponnuru Hari Kiran , Reddy Charan Kumar 
Published: October 2019

Abstract
Background: Light-based detection agents using autofluorescence may be helpful in the detection of early dysplasia, which would otherwise be misdiagnosed as nondysplastic by conventional oral examination (COE) with white light. Visually-enhanced lesion scope (VELscope) is one of such an aid used for the purpose. A meta-analysis was carried out on the sensitivity and specificity of VELscope that would enable in providing evidence of its usage in oral dysplasia. Materials and Methods: MeSH terms such as auto florescence in oral dysplasia, VELscope, Oral ID, Identifi, in a different medical database such as PubMed, Cochrane, EBSCO, and Google scholar was carried out by four research associates. The total articles available were 242, of which, 230 were excluded based on strict criteria of randomized control trials and proper design. Finally, only 12 studies were chosen for the present analysis. Of 1643 patients from 12 studies, 1264 patients had undergone the autofluorescence examination after the COE. Only 774 patients have shown the loss of fluorescence with VELScope examination and 487 had retained the fluorescence. Biopsy was performed on 1176 patients after the autofluorescence examination in the areas where there was the loss of fluorescence. The available data were subjected to software Review Manager for analysis. Results and Discussion: Of the 11 studies analyzed, majority of them showed that the autofluorescence device were sensitive enough > 0.70; however, the values of sensitivity and specificities varied significantly. With the VELscope the diagnostic performance of the inexpert examiner was not improved, obtaining a sensitivity of 0.40 (95% of confidence interval [CI]: 0.406–0.773) and a specificity of 0.80 (95% CI: 0.614–0.923). Conclusion: The new technique may help as an adjunct to histopathology in detecting the dysplasia initially and stop further progression to the carcinoma.
Hyperprogression after immunotherapy
Authors: Abbas Waseem , Rao Ranga Raju , Popli Swati 
Published: October 2019

Abstract
Introduction: Checkpoint inhibitors demonstrate very good anticancer effects, and some patients are long-time responders. As our experience to use these drugs increases, we see more and more patients having different kind of side effects which are usually not seen with chemotherapy. We have observed a subset of patients who appear to be “hyper-progressors,” with a greatly accelerated rate of tumor growth and clinical deterioration compared to pretherapy, which was also recently reported by Institut Gustave Roussy. Materials and Methods: Medical records from all patients (N = 50) prospectively treated in our hospital by anti-PD-1/PD-L1 were analyzed. The tumor growth rate (TGR) prior (“REFERENCE;” REF) and upon (“EXPERIMENTAL”; EXP) anti-PD-1/ PD-L1 therapy was compared to identify patients with accelerated tumor growth. Associations between TGR and overall survival (OS) were computed. Results: Hyperprogressive disease (HPD) was defined as a RECIST progression at the first evaluation and as a ≥2-fold increase of the TGR between the REF and the EXP periods. Of 50 evaluable patients, four patients (8%) were considered as having HPD. At progression, patients with HPD had a higher rate of new lesions. HPD was associated with a worse outcome (OS). Conclusion: Hyperprogression was seen in 4 of 50 (8%) of patients, three of which had urothelial cancer and one malignant melanoma, treated with anti-PD-1 or anti-PD-L1 monotherapy. Patients, on immunotherapy, qualifying for hyperprogression had shorted OS. It is important to have a better understanding of hyperprogression on immunotherapy which shall be addressed in the ongoing immunotherapy studies.
Sesiunea Naţională de Comunicări Ştiinţifice Studenţeşti, pe teme de Silvicultură şi Protecţia Mediului, ediția a V-a, Șipoțel, Suceava, 24-25 mai 2019
Authors: Popa Andrei 
Published: October 2019

Cea de-a 5-a ediție a Conferinței Naționale Studențești pe teme de Silvicultură și Protecția Mediului a fost găzduită de Facultatea de Silvicultură din cadrul Universității „Ștefan cel Mare” din Suceava. Aceasta a avut loc în perioada 24-25 mai 2019 la cabana Șipoțel din Suceava. În cadrul acestei sesiuni, au fost prezentate douăzeci și șase lucrări de către studenți din șase universități, atât naționale, cât și internaționale: Universitatea „Ștefan cel Mare” din Suceava, Universitatea „Transilvania” din Brașov, Universitatea de Științe Agricole și Medicină Veterinară Cluj-Napoca, Universitatea din Științe Agricole și Medicină Veterinară din București, Universitatea din Oradea și Universitatea Agrară de Stat din Moldova. Principalele subiecte ale prezentărilorau fost despre protecția pădurilor, dendrometria și inventarele pădurilor, silvicultură, fiziologie, studiul lemnului, exploatarea pădurilor, vânătoare, genetică. Obiectivul principal al acestei întâlniri a fost de a aduce împreună studenții interesați de subiectele legate de păduri și de a dezbate cercetările lor. Această sesiune științifică este o bună oportunitate pentru tinerii cercetători de a dezvolta abilități de comunicare și de a găsi noi perspective de studiu.
The Impact of Performance Appraisal on Employee Performance in Banks Operating in the South of Jordan
Authors: Rahahleh Arwa Hisham , Alabaddi Zaid Ahmad , Moflih Monira Abdallah 
Published: October 2019

This research was about performance appraisal and its effect on employees’ work performance. The major aim of the research was to investigate the effect of performance appraisal on employees’ work performance of banks in the South of Jordan. This study also aimed at investigating the major elements of performance appraisal which included: establishing performance standards, establishing communication standards, measuring actual performance with established standards, discussing the appraisal with employees and giving feedback. In conducting this study, the required data was collected through a closed ended structured questionnaire. The questionnaire was adopted and adapted from many related studies. The procedures used to determine the comprehensive sample from a total population of 260 employees was the following: First, the target population was identified; second, the researcher used a formula based-sample size determination. Basically, a total of 260 questionnaires were distributed to the sampled employees and 260 were returned which represented a 100% response rate. The 260 returned questionnaires were then analyzed using smart PLS which is specially used for Structural Equation Modeling, path analysis, and confirmatory factor analysis. It is also known as analysis of covariance or causal modeling software. A descriptive statistics and correlation analysis was performed. The results of the study showed that performance appraisal has a mainly positive effect on employee performance in the banking sector of the South of Jordan. There correlation analysis showed that there was a positive and some negative association (Very strong association) between performance appraisal and employee performance.
Atenção Primária à Saúde quebrando tabus
Authors: Vieira Renata Carneiro , Teixeira Débora Silva , Borret Rita , Ornelas Denize , Sarno Murilo Moura , Junior Ademir Lopes 
Published: October 2019

A produção acadêmica sobre sexualidade e diversidade apresenta lacunas importantes, e muitas das diretrizes de cuidados clínicos a populações específicas são baseadas em baixo grau de evidência científica, como ocorre com a população de Lésbicas, Gays, Bissexuais, Travestis, Transexuais e Intersexuais (LGBTI). Dessa forma, a fundação do Grupo de Trabalho (GT) de Gênero, Sexualidade, Diversidade e Direitos, junto à Sociedade Brasileira de Medicina de Família e Comunidade surge com o importante objetivo de promover estudos e debates sobre gênero e sexualidade a fim de promover direitos, diversidade e equidade na Atenção Primária à Saúde (APS). Como uma das atividades desse GT foi idealizado e construído o I Seminário Sexualidade e Diversidade, com o tema “Atenção Primária à Saúde Quebrando Tabus”, que aconteceu em São Paulo, entre os dias 20 e 22 de abril de 2018. O presente texto tem como objetivo apresentar como se deu a construção do evento, descrevendo os espaços realizados e as impressões dos participantes sobre o seminário. A programação foi elaborada a partir da demanda dos fóruns do GT (grupos de e-mail, Facebook e WhatsApp), sendo proposto quatro eixos para as atividades: 1- Pesquisa/produção acadêmica, 2- Assistência/temas clínicos, 3- Educação médica e 4- Representatividade e políticas públicas. Ao todo, foram realizadas 6 mesas redondas, 6 oficinas, 3 performances artísticas e 1 exposição cultural, contando com a participação de 202 pessoas, de 11 estados. O GT atingiu seu objetivo com esse seminário de produzir conhecimento e discutir sobre sexualidade e gênero, com foco na Atenção Primária, com médicos de família e comunidade, profissionais e estudantes da saúde. Considerando que a procura pelo Seminário foi maior que a esperada e que a discussão dos temas não se encerram em um evento, a intenção é de que o Seminário se torne parte da agenda regular da SBMFC.
Could low atmospheric pressure stunning (LAPS) be suitable for pig slaughter? A review of available information
Authors: Bouwsema JA , Lines JA 
Published: October 2019

AbstractLow atmospheric pressure stunning (LAPS) is a slaughter technique which may be less stressful for pigs (Sus scrofa domestica) than current commercial stunning and slaughter methods. The main methods used currently for slaughtering pigs are electric and carbon dioxide stunning, both of which are widely recognised as stressful for pigs. There is currently no published research on the use of LAPS for stunning adult pigs, however there is a significant body of relevant experience from investigations into the effects of low pressure and hypoxia on humans, hypoxia for killing pigs and the use of LAPS for killing poultry, rats and piglets. In this paper, the basic physics and biology of LAPS is briefly reviewed and relevant experience from research with humans, poultry, rats and piglets is presented. On the basis of this information, some initial parameters for LAPS trials with pigs are proposed, potential welfare issues identified and an approach to achieving LAPS at a commercially viable speed is outlined. While the effects of LAPS on pigs is, at present, uncertain, the evidence from research with humans and other animals suggests that healthy, fasted pigs undergoing LAPS are unlikely to suffer from air hunger or from pain. Any pigs suffering from upper respiratory tract disease, tooth decay or excess gas in the alimentary canal may, however, experience pain. A total killing cycle is likely to require 9 to 14 min. To implement LAPS in a commercial, high throughput processing plant will require the use of multiple decompression cylinders. The evidence available suggests that LAPS could be commercially viable for pig slaughter and that for most pigs it will be less stressful than current commercial slaughter methods.
Long-term hyperalgesia and traumatic neuroma formation in tail-docked lambs
Authors: Larrondo C , Bustamante H , Paredes E , Gallo C 
Published: October 2019

AbstractThis study aimed to determine if tail-docking induces long-term hyperalgesia, chronic pain and histopathological changes in tail stumps of tail-docked lambs. Fifty male lambs of 45 days of age were randomly allocated in two groups. One group of 25 lambs was tail-docked using a hot cautery iron and a second group of 25 lambs was subjected only to handling as a control group (undocked lambs). Prior to tail-docking and at intervals of 15, 30, 60 and 90 days after the procedure, infra-red thermography (IT) and mechanical nociceptive thresholds (MNTs) tests were carried out in both lambs’ tails/stumps, and animals were weighed. In addition, the visual degree of inflammation of tail stumps was evaluated. Finally, animals were slaughtered in a commercial slaughterhouse and tail sections of ten lambs from each group were examined histopathologically. Tail-docking was associated with an inflammatory process according to IT and visual observation in tail stumps at 15 and 30 days post-docking. Tail-docked lambs had lower MNTs than undocked lambs at all evaluated times after tail-docking, indicating the presence of long-term hyperalgesia. Also, traumatic neuroma formation was found in tail stumps of 2/10 tail-docked lambs, and 6/10 presented neuromatous tissue development. It is concluded that tail-docking induces acute and chronic pain in lambs, initially through inflammation, and then via long-term hyperalgesia and traumatic neuroma formation. These long-term findings would have negative implications for the animal welfare of tail-docked lambs.