bluuebunny/crossref_metadata_2025_split huggingface dataset:
New South American genus of Iassinae (Hemiptera: Cicadellidae) and additional morphological characters for two Neotropical species of Neobalinae and Nioniinae
Authors: Defea Barbara Soledad , Paradell Susana Liria 
Published: November 2019

AbstractThe new iassine leafhopper genus Ana gen. nov is described, based on the type species Ana doctrix sp. nov. from Argentina, and placed in the tribe Hyalojassini. The new genus is distinguished from other Neotropical Hyalojassini genera by setose forewings, submarginal vein evanescent apically and appendix narrower than first apical cell, male pygofer with a triangular expansion turned mesad on ventral margin, lacking hooks, styles bifid basally, and female sternite VII short, with posterior margin concave. The subfamilies Neobalinae and Nioniinae are recorded for the first time from Argentina. New female morphological characters of Calliscarta fasciata (Osborn) (Neobalinae) and the male terminalia of Nionia major (Osborn) (Nioniinae) are provided. An updated key to the 12 subfamilies of Cicadellidae present in Argentina is provided.
British Campaigns for Solidarity with Argentina and Chile
Authors: Livingstone Grace 
Published: November 2019

The Chile solidarity movement persuaded British Labour governments (1974–1979) to introduce a range of measures against the Pinochet regime. But campaigners lobbying against the Argentine dictatorship (1976–1983) had less impact on policy. Neither these Labour governments nor the subsequent Conservative government imposed any sanction on the Argentine dictatorship, until the invasion of the Falkland Islands. This article explores why in Britain – and Europe – the Chile campaign had greater public appeal than the Argentina solidarity campaigns. It identifies a number of common factors across Europe which explain why the anti‐Pinochet cause generated more support than the Argentina campaign.
RPV‐modified epirubicin and dioscin co‐delivery liposomes suppress non‐small cell lung cancer growth by limiting nutrition supply
Authors: Kong Liang , Cai Fu‐yi , Yao Xue‐min , Jing Ming , Fu Min , Liu Jing‐jing , He Si‐yu , Zhang Lu , Liu Xin‐ze , Ju Rui‐jun , Li Xue‐tao 
Published: November 2019

AbstractChemotherapy for non‐small cell lung cancer (NSCLC) is far from satisfactory, mainly due to poor targeting of antitumor drugs and self‐adaptations of the tumors. Angiogenesis, vasculogenic mimicry (VM) channels, migration, and invasion are the main ways for tumors to obtain nutrition. Herein, RPV‐modified epirubicin and dioscin co‐delivery liposomes were successfully prepared. These liposomes showed ideal physicochemical properties, enhanced tumor targeting and accumulation in tumor sites, and inhibited VM channel formation, tumor angiogenesis, migration and invasion. The liposomes also downregulated VM‐related and angiogenesis‐related proteins in vitro. Furthermore, when tested in vivo, the targeted co‐delivery liposomes increased selective accumulation of drugs in tumor sites and showed extended stability in blood circulation. In conclusion, RPV‐modified epirubicin and dioscin co‐delivery liposomes showed strong antitumor efficacy in vivo and could thus be considered a promising strategy for NSCLC treatment.
Integrin α11 in non–small cell lung cancer is associated with tumor progression and postoperative recurrence
Authors: Ando Takahiro , Kage Hidenori , Matsumoto Yoko , Zokumasu Koichi , Yotsumoto Takuma , Maemura Keita , Amano Yosuke , Watanabe Kousuke , Nakajima Jun , Nagase Takahide , Takai Daiya 
Published: November 2019

AbstractIntegrins are transmembrane proteins that mediate cell adhesion to the extracellular matrix. Integrin α11 (ITGA11) is not expressed in normal alveolar epithelial cells and is a known receptor for collagen. While integrin α11β1 overexpression in the tumor stroma has been associated with tumor growth and metastatic potential of non–small cell lung cancer (NSCLC), little is known about the role of ITGA11 in tumor cells. Thus, we examined the RNA expression of ITGA11 by quantitative RT‐PCR in 80 samples collected from NSCLC patients who had undergone surgical resection and analyzed the clinical outcomes. We found that high expression of ITGA11 was associated with lower recurrence‐free survival in all NSCLC patients (P = 0.043) and in stage I NSCLC patients (P = 0.049). These results were consistent with in silico analyses of the Cancer Genome Atlas database. We also analyzed cell proliferation, migration and invasion capacity in lung cancer cell lines after overexpression of ITGA11. Overexpression of ITGA11 in lung cancer cell lines had little effect on cell proliferation but resulted in increased migration and invasion capacity. Our findings suggest that ITGA11 plays a significant role in cancer migration and invasion, leading to higher recurrence. ITGA11 expression may be a predictor of poor prognosis in patients with surgically resected NSCLC.
Density‐dependent effects on salmonid populations: A review
Authors: Grossman Gary D. , Simon Troy N. 
Published: November 2019

AbstractWe reviewed 199 published data sets (21 species) to assess the relative frequency of various density‐dependent processes in salmonids. We examined studies for the presence or absence of density‐dependence: in growth, mortality, fecundity and recruitment. Based on data from all studies pooled 71% showed density‐dependence in growth, 23% found density‐dependence in mortality, 2% detected density‐dependence in fecundity and 4% displayed density‐dependence in recruitment. Most studies at the population level (e.g. changes in abundance or means of growth, mortality or fecundity) demonstrated density‐dependence; however, these studies were not common, likely because they require long time series of data (at least 3–4 times mean generation time for the species). Our review indicated there was no evidence that the probability of finding density‐dependent effects differed among the 21 species examined, but the number of studies per species varied substantially (5 [minimum for analysis] – 20+); hence, this finding should be viewed as tentative. Most salmonid species showed evidence of density‐dependence in growth; however, few studies examined density‐dependent effects on fecundity or recruitment, and further study is needed on these phenomena. There was no evidence that density‐dependent effects were restricted to a particular habitat type or geographic region.
Dynamics of movement‐related cortical potentials and sensorimotor oscillations during palmar grasp movements
Authors: Savić Andrej M. , Lontis Eugen R. , Mrachacz‐Kersting Natalie , Popović Mirjana B. 
Published: November 2019

AbstractMovement‐related cortical potentials (MRCP) and sensorimotor oscillatory electroencephalographic (EEG) activity (event‐related desynchronization/synchronization—ERD/ERS) provide complementary information of the associated motor activity. The aim of this study was to provide comparative spatio‐temporal analysis of both EEG phenomena associated with palmar grasping motions including hand opening and closing phases. Nine healthy participants were instructed to perform self‐paced, right hand grasping movements. EEG was recorded from 28 sites synchronous with electromyography (EMG) of wrist/fingers extensors and flexors. Statistical analysis of the EEG data revealed significant differences (p < .05) between the idle state (baseline) and motor preparation/execution periods in majority of recorded channels. The earliest statistical significance in MRCPs was observed for channel FC3 at −460.9 ms, while the earliest significant ERD was observed at 164.1 ms for channel C3. MRCP and ERD/ERS topographies in our study are in line with the results of previous studies comparing MRCP and ERD/ERS spatio‐temporal patterns during upper limb movements, however, results of our study show that MRCP significant differences compared to the baseline appear in most channels earlier than ERD (on average 613.6 ± 191.5 ms earlier). This implies an advantage of MRCP signals for grasping movements' prediction, which is in contrast to previous reports. Moreover, combined spatio‐temporal information on MRCP and ERD/ERS presented in this paper may serve for future optimization of grasp movement prediction/detection hybrid algorithms in the context of restorative brain–computer interface technology.
Long‐term surface application of dairy liquid manure to soil under no‐till improves carbon and nitrogen stocks
Authors: Cavalcante J. S. , Favaretto N. , Dieckow J. , Cherobim V. F. , Barth G. 
Published: November 2019

AbstractManure application and no‐till management improve soil quality, crop yields and C inputs, but little specific knowledge is available regarding the combined effect of long‐term dairy liquid manure (DLM) application and no‐till management on soil organic matter status and soil structure in topsoils. Here, we assess the impacts of surface‐applied DLM for a 10‐year period on soil total organic carbon (TOC) and nitrogen (TN) concentrations and stocks, on organic matter fractions and on soil physical‐structural attributes in a no‐till crop rotation system on clayey Ferralsol under no‐till crop rotation management in a subtropical climate. Four rates of DLM (0, 60, 120 and 180 m3 ha−1 year−1) were applied in a randomized block design with four replications. Soil samples were collected to calculate TOC and TN stocks to 100‐cm depth and organic matter fractions in the 0–5‐cm layer, and physical indicators of soil quality: bulk density, macroporosity and microporosity and aggregate stability. The largest DLM rates (120 and 180 m3 ha−1 year−1) added 3.8–5.8 Mg C ha−1 year−1 as manure, increased crop residue input by 0.6 Mg C ha−1 year−1, and increased TOC stock by 17% and TN stock by 27% in the top 10 cm of soil, at annual accumulation rates that averaged 0.72 Mg C ha−1 year−1 and 86 kg N ha−1 year−1. Stocks of TOC and TN in the sand‐POM (particulate organic matter) fraction under the 180 m3 ha−1 year−1 rate increased by 49 and 63%, and in the silt‐MOM (mineral‐associated organic matter) fraction by 30 and 47%, respectively. In the clay‐MOM fraction, the change in TOC was not significant, but the TN increased by 16%. Soil physical‐structural attributes (bulk density, porosity and aggregates) were improved by DLM application in the 10‐cm layer and followed the soil carbon and nitrogen increments. Overall, the DLM amendment applied on the soil surface of no‐till proved to be a strategy to ameliorate soil organic matter status, an important factor for agronomic and environmental benefits, besides improving crop biomass production.Highlights
Long‐term application of liquid manure increased concentration and stock of SOC and TN in the 0–10‐cm layer.
Increases of 0.72 Mg C ha−1 year−1 and 86 kg N ha−1 year−1 were observed in the 10‐cm topsoil with manure.
SOC and TN increased in the sand‐POM and silt‐MOM size fractions but not the clay‐MOM fraction.
Improvements to soil physical‐structural attributes were related to organic matter changes.
Insights from bitcoin trading
Authors: Jain Pankaj K. , McInish Thomas H. , Miller Jonathan L. 
Published: November 2019

AbstractWe examine commonality in returns and volume for Bitcoin–fiat currency pairs, each trading in a country with a single time zone. Bitcoin has substantial volume and obeys the theory related to commonality, liquidity, and price discovery. We find evidence that one common factor explains 68% of the variance in hourly volume. Though trading is higher on weekdays, there is substantial weekend trading, reflecting high retail participation. Volume is higher on exchanges during local working hours, as seen in forex markets, supporting the view that trading patterns depend on the location of trade rather than the location of the asset traded.
Gabapentin for uremic pruritus: a systematic review of randomized controlled trials
Authors: Eusebio‐Alpapara Kathleen May V. , Castillo Rochelle L. , Dofitas Belen L. 
Published: November 2019

AbstractUremic pruritus is one of the most prevalent and bothersome dermatologic symptoms in patients with end‐stage renal disease. Some studies suggest a possible neuropathic cause of uremic pruritus. Gabapentin, an anticonvulsant, may control pruritus with neuropathic origin. The objectives of this study were to assess the efficacy of gabapentin in reducing pruritus scores of patients with uremic pruritus and evaluate its safety among dialysis patients. Meta‐analysis of randomized controlled trials, using gabapentin as treatment for uremic pruritus among hemodialysis patients was included and analyzed using Review Manager Version 5.1.4 software. Seven out of 17 screened articles were included, with a total of 315 participants. Meta‐analysis of the incidence of improved pruritus scores after treatment from four studies (n = 171) showed that treatment with gabapentin decreased the severity of uremic pruritus as compared to the placebo (risk ratio = 0.18; 95% confidence interval: 0.09, 0.33; I2 = 4%: P =< 0.00001). Six studies (n = 290) presented with incidence of adverse drug events such as dizziness, drowsiness, and somnolence. In the pooled analysis, treatment with gabapentin was associated with a higher incidence of adverse drug events compared to the comparator drugs, but the results were not significant (risk ratio = 1.3, 95% confidence interval: 0.81, 2.11; P = 0.28, I2 = 37%). The results of this systematic review suggest that gabapentin is efficacious and safe in improving uremic pruritus among dialysis patients.
State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS)
Authors: Rodríguez‐Jiménez Pedro , Jimenez Yolanda D. , Reolid Alejandra , Sanmartın‐Jimenez Onofre , Garces Joan R. , Rodríguez‐Prieto Manuel A. , Medrano Roman M. , Vilarrasa Eva , de Eusebio‐Murillo Esther , Redondo Pedro , Ciudad‐Blanco Cristina , Morales‐Gordillo Victoriano , Toll‐Abelló Agustí , Artola‐Igarza Juan L. , Pacheco María L.A. , Markixana Irati A. , Fernández Ricardo S. , Rubio Alberto A. , Vázquez‐Veiga Hugo , Flórez‐Menéndez Angeles , de la Cueva Dobao Pablo , Botella‐Estrada Rafael , Garcia‐Bracamonte Beatriz , Carnero‐González Lucia , Ruiz‐Salas Veronica , Sánchez‐Sambucety Pedro , López‐Estebaranz Jose L. , Gil Pilar , Barchino Lucia , Arenal Matías M. , Ocerin‐Guerra Izascun , Hueso Luis , Seoane‐Pose María J. , Gonzalez-Sixto Beatriz , Cano‐Martinez Natividad , Escutia‐Muñoz Begoña , Ortiz‐Romero Pablo L. , Garcia‐Doval Ignacio , Descalzo Miguel A. ,   on behalf of REGESMOHS (Registro Español de Cirugía de Mohs)
Published: November 2019

AbstractBackgroundThe use of Mohs micrographic surgery (MMS) for rare cutaneous tumors is poorly defined. We aim to describe the demographics, tumor presentation and topography, surgery characteristics and complications of MMS for rare cutaneous tumors in a national registry.MethodsProspective cohort study of patients treated with MMS in Spain between July 2013 and June 2018. The inclusion criteria were patients with cutaneous tumors with final diagnosis different from basal cell carcinoma, squamous cell carcinoma, dermatofibrosarcoma protuberans, or any kind of melanoma.ResultsFive thousand and ninety patients were recorded in the registry, from which only 73 tumors (1.4%) fulfilled the inclusion criteria: atypical fibroxanthoma (18), microcystic adnexal carcinoma (10), extramammary Paget's disease (7), Merkel cell carcinoma (5), dermatofibroma (4), trichilemmal carcinoma (4), desmoplastic trichoepithelioma (4), sebaceous carcinoma (3), leiomyosarcoma (2), porocarcinoma (2), angiosarcoma (2), trichoblastoma (1), superficial acral fibromyxoma (1), and others (10). No intra‐surgery morbidity was registered. Postsurgery complications appeared in six patients (9%) and were considered mild. Median follow‐up time was 0.9 years during which three Merkel cell carcinomas, one angiosarcoma, one microcystic adnexal carcinoma, and four others recurred (12.3%).ConclusionThis national registry shows that rare cutaneous tumors represent a negligible part of the total MMS performed in our country with a low complication rate.
The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life
Authors: Ganal‐Vonarburg Stephanie C. , Duerr Claudia U. 
Published: November 2019

SummaryImmunity is shaped by commensal microbiota. From early life onwards, microbes colonize mucosal surfaces of the body and thereby trigger the establishment of immune homeostasis and defense mechanisms. Recent evidence reveals that the family of innate lymphoid cells (ILCs), which are mainly located in mucosal tissues, are essential in the maintenance of barrier functions as well as in the initiation of an appropriate immune response upon pathogenic infection. In this review, we summarize recent insights on the functional interaction of microbiota and ILCs at steady‐state and throughout life. Furthermore, we will discuss the interplay of ILCs and the microbiota in mucosal infections focusing on intestinal immunity.
‘Layered immunity’ and the ‘neonatal window of opportunity’ – timed succession of non‐redundant phases to establish mucosal host–microbial homeostasis after birth
Authors: Hornef Mathias W. , Torow Natalia 
Published: November 2019

SummaryThe intricate host–microbial interaction and the overwhelming complexity of the mucosal immune system in the adult host raise the question of how this system is initially established. Here, we propose the implementation of the concept of the ‘postnatal window of opportunity’ into the model of a ‘layered immunity’ to explain how the newborn's mucosal immune system matures and how host–microbial immune homeostasis is established after birth. We outline the concept of a timed succession of non‐redundant phases during postnatal immune development and discuss the possible influence of external factors and conditions.
Decreased microcirculatory function measured by perfusion index is a novel indicator of diabetic kidney disease in patients with type 2 diabetes
Authors: Okada Hiroshi , Tanaka Muhei , Yasuda Takashi , Okada Yuki , Norikae Hisahiro , Fujita Tetsuya , Nishi Takashi , Oyamada Hirokazu , Yamane Tetsuro , Fukui Michiaki 
Published: November 2019

AbstractAims/IntroductionDiabetic kidney disease has been considered as an important risk factor of cardiovascular disease. Chronic hypoxia is considered to be the main cause of renal injury. Diminished microcirculatory blood flow could be associated with hypoxia in the kidney. Whether diminished microcirculation is associated with diabetic kidney disease has not yet been reported. Here, we investigated the correlation between microcirculatory function and diabetic kidney disease in patients with type 2 diabetes.Materials and MethodsOur cross‐sectional study included 574 patients who were admitted to Matsushita Memorial Hospital in Moriguchi, Japan, for type 2 diabetes. Microcirculatory function was assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. We measured the PI for all patients.ResultsThe median age and PI values were 70 years (range 60–77 years) and 2.8% (range 1.6–4.8%). Multiple regression analyses showed that the PI independently correlated with the logarithm of urinary albumin excretion (P = 0.009) and estimated glomerular filtration rate (P = 0.005), respectively. Multiple logistic regression analyses showed that patients with systolic blood pressure (SBP) greater than the median and PI less than or equal to the median (high‐low group) had a significantly increased odds of albuminuria compared with those with SBP less than or equal to the median and PI greater than the median (low‐high group), and patients with SBP greater than the median and PI less than or equal to the median (high‐low group) had a significantly increased odds of estimated glomerular filtration rate <60 mL/min per 1.73 m2 compared with those with SBP less than or equal to the median and PI greater than the median (low‐high group) or SBP greater than the median and PI greater than the median (high‐high group).ConclusionsPI could be a novel indicator of diabetic kidney disease in patients with type 2 diabetes.
Evaluation of non‐target effects of OMRI‐listed insecticides for management of Drosophila suzukii Matsumura in berry crops
Authors: Sarkar Nupur , Rhodes Elena M. , Spies Janine , Roubos Craig R. , Little Brian A. , Sial Ashfaq A. , Fanning Philip D. , Isaacs Rufus , Liburd Oscar E. 
Published: November 2019

AbstractThe spotted wing drosophila, Drosophila suzukii Matsumura, is an invasive pest of many fruit crops throughout North America, South America and Europe. The presence of this destructive pest has led to an increase in the number of insecticide applications. While conventional growers have an arsenal of different insecticides at their disposal, organic growers have a limited selection of effective options and rely heavily on applications of Entrust®, the organic formulation of spinosad. An important part of research is to develop more tools for organic growers and evaluate the effects of insecticides intended to target D. suzukii on natural enemies in the system. The effects of six organic pesticides alone and in combination with three adjuvants and two phagostimulants were tested in laboratory bioassays on three common natural enemies in berry production systems including two predators, Chrysoperla rufilabris and Orius insidiosus, and a parasitoid wasp, Aphidius colemani. Under the IOBC toxicity rating scale, spinosad was rated consistently from slightly harmful to harmful across natural enemy species and residue age (the effects of pesticides over time). Sabadilla alkaloids caused mortality to O. insidiosus equal to that of spinosad. All tested pesticides were at least slightly harmful to A. colemani, and the adjuvant polyether‐polymethylsiloxane‐copolymer polyether caused mortality that was not significantly different from spinosad. In general, neither the addition of adjuvants nor phagostimulants increased the mortality of the insecticides tested. The exception was polyether‐polymethylsiloxane‐copolymer polyether, but it is unclear whether it increased the toxicity of the pesticides or was simply toxic itself since it caused high mortality to A. colemani when applied alone. Sublethal effects were measured for two predatory species by measuring eggs laid and % egg hatch. Minimal sublethal effects were observed in C. rufilabris. In contrast, all tested insecticides caused reduced egg hatch in O. insidiosus compared with the control.
Transmission of Pantoea agglomerans—A paratransgenic control agent—Within a Homalodisca vitripennis population
Authors: Arora Arinder K. , Miller Thomas A. , Durvasula Ravi V. 
Published: November 2019

AbstractParatransgenic control of pests can be an alternative to chemical control, which is associated with environmental contamination, and higher input cost. We have recently developed paratransgenic control strategy to block transmission of the Pierce's disease pathogen—Xylella fastidiosa by its arthropod vector—Homalodisca vitripennis (the glassy‐winged sharpshooter) using antimicrobial peptide‐expressing strains of Pantoea agglomerans. In the present study, we report horizontal transmission of one of such P. agglomerans strains from H. vitripennis. This process indicates that P. agglomerans can self‐sustain in a population of H. vitripennis and, thus, can provide paratransgenic control of X. fastidiosa in field. These results also provide basis for future field studies.