bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery, optimization, and cellular activities of 2-(aroylamino)cinnamamide derivatives against colon cancer cells
Authors: Omar Abdelsattar M. , Elhaggar Radwan S. , Safo Martin K. , Abdelghany Tamer M. , Ahmed Mostafa H. , Boothello Rio , Patel Bhaumik B. , Abdel-Bakky Mohamed S. , El-Araby Moustafa E. 
Published: December 2019

ABSTRACTCurcumin andtrans-cinnamaldehyde are acrolein-based Michael acceptor compounds that are commonly found in domestic condiments, and known to cause cancer cell deathviaredox mechanisms. Based on the structural features of these compounds we designed and synthesized several 2-cinnamamido-N-substituted-cinnamamide (bis-cinnamamide) compounds. One of the derivatives, (Z)-2-[(E)-cinnamamido]-3-phenyl-N-propylacrylamide (1512)showed a moderate antiproliferative potency (HT116 cell line inhibition of 32.0 µM ± 2.6) with proven cellular activities leading to apoptosis. Importantly,1512exhibited good selectivity toxicity on cancer cells over noncancerous cells (IC50of C-166 cell lines >100 µM), and low cancer cell resistance at 100 µM dose (growth rate 10.1±1.1%). We subsequently carried out structure activity relationship studies with1512. Derivatives with electron rich moiety at the aryl ring of the 2-aminocinnamaide moiety exhibited strong antiproliferative action while electron withdrawing groups caused loss of activity. Our most promising compound,4112[(Z)-3-(1H-indol-3-yl)-N-propyl-2-[(E)-3-(thien-2-yl)propenamido)propenamide] killed cancer cells at IC50= 0.89 ± 0.04 µM (Caco-2), 2.85 ± 1.5 (HCT-116) and 1.65 ± 0.07 (HT-29), while exhibiting much weaker potency on C-166 and BHK normal cell lines (IC50= 71 ± 5.12 and 77.6 ± 6.2 µM, respectively). Cellular studies towards identifying the compounds mechanism of cytotoxic activities revealed that apoptotic induction occurs in part due to oxidative stress. Importantly, the compounds showed inhibition of cancer stem cells that are critical for maintaining the potential for self-renewal and stemness. The results presented here show discovery of Michael addition compounds that potently kill cancer cells by a defined mechanism, with minimal effect on normal noncancerous cell.
Stochastic dynamics of extra-chromosomal DNA
Authors: Pichugin Yuriy , Huang Weini , Werner Benjamin 
Published: December 2019

AbstractNuclear extra-chromosomal DNA (ecDNA) is highly prevalent in human tumours. ecDNA amplifications can promote accessible chromatin, oncogen over-expression and imply a worse clinical prognosis. Yet, little is known about the evolutionary process of ecDNA in human cancers. Here, we develop the theoretical foundation of the ecDNA somatic evolutionary process combining mathematical, computational and experimental approaches. We show that random ecDNA segregation leads to unintuitive dynamics even if ecDNA is under very strong positive selection. Patterns of inter- and intra-tumour ecDNA and chromosomal heterogeneity differ markedly and standard approaches are not directly applicable to quantify ecDNA evolution. We show that evolutionary informed modelling leads to testable predictions on how to distinguish positively selected from neutral ecDNA dynamics. Our predictions describe the dynamics of circular amplicons in GBM39 cell line experiments, suggesting a 300% fitness increase due to circular extra-chromosomalEGFRvIIIamplifications. Our work lies the basis for further studies to quantitate ecDNA somatic evolutionary processes.
Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression
Authors: Waschow Marcel , Wang Qi , Saary Paul , Klein Corinna , Aschenbrenner Sabine , Jechow Katharina , Maier Lorenz , Tirier Stephan , Schoell Brigitte , Chudoba Ilse , Dietz Christian , Dreidax Daniel , Jauch Anna , Sprick Martin , Herrmann Carl , Eils Roland , Conrad Christian 
Published: December 2019

ABSTRACTAbnormal karyotypes, namely aneuploidy, can be detected in nearly all cancer entities at different grades. The impact of these altering mutations on epigenetic regulation, especially on promoter-enhancer interactions are not well understood. Here, we applied a 3D model of MCF10A cells in a high-content screen to measure induced aneuploidy by RNA interference of 82 mitotic genes associated with aneuploidy and breast cancer. Perturbation of ESPL1 and TOP2A expression led to increased mitotic instability and subsequent aneuploidy and polylobed nuclei. During acinus formation these polylobed cells disrupted proper acinus rotation inhibiting the development of a hollow lumen and a polarized outer cell layer. Further, gene expression profiling identified upregulated CCND1 among other breast cancer related genes. We show that acquisition of aneuploidy affects the morphogenesis of MCF10A acini and expression of cancer relevant genes. By conducting 4C chromosome capturing experiments we linked the alteration of interactions of the promoter region to CCND1 upregulation.
Gene regulatory networks associated with lateral root and nodule development in soybean
Authors: Smita Shuchi , Kiehne Jason , Adhikari Sajag , Zeng Erliang , Ma Qin , Subramanian Senthil 
Published: December 2019

AbstractLegume plants such as soybean produce two major types of root lateral organs, lateral roots and root nodules. A robust computational framework was developed to predict potential gene regulatory networks (GRNs) associated with root lateral organ development in soybean. A genome-scale expression dataset was obtained from soybean root nodules and lateral roots and subjected to biclustering using QUBIC. Biclusters (BCs) and transcription factor (TF) genes with enriched expression in lateral root tissues were converged using different network inference algorithms to predict high confident regulatory modules that are repeatedly retrieved in different methods. The ranked combination of results from all different network inference algorithms into one ensemble solution identified 21 GRN modules of 182 co-regulated genes networks potentially involved in root lateral organ development stages in soybean. The pipeline correctly predicted previously known nodule- and LR-associated TFs including the expected hierarchical relationships. The results revealed high scorer AP2, GRF5, and C3H co-regulated GRN modules during early nodule development; and GRAS, LBD41, and ARR18 co-regulated GRN modules late during nodule maturation. Knowledge from this work supported by experimental validation in the future is expected to help determine key gene targets for biotechnological strategies to optimize nodule formation and enhance nitrogen fixation.
Are teams experiencing relationship conflicts destined to fail
Authors: Yuan Ling , Yu Yue , Liu Pan 
Published: December 2019

PurposeThe purpose of this study is to find ways to mitigate the negative consequences of relationship conflict under the situation that while the negative role of team relationship conflict has been underscored in prior literature, few studies try to alleviate it. With the development of positive psychology, a stream focusing on the role of emotion in conflict management emerges. First, the authors want to explore the mediating role of members’ work engagement in the association between relationship conflict and members’ job performance. Moreover, they want to explore contingent roles of perceived team leader’s emotional intelligence and members’ emotion regulation strategies (i.e. cognitive reappraisal and expressive suppression) in moderating the effect of relationship conflict on members’ work engagement.Design/methodology/approachUsing a data set of 363 individuals working in 73 teams in service sectors, the authors empirically examined the cross-level model with hierarchical linear model.FindingsRelationship conflict was negatively related to members’ job performance while members’ work engagement mediated this relationship. Moreover, perceived team leader’s emotional intelligence mitigated the negative effect of relationship conflict on members’ work engagement, while members’ expressive suppression strategy intensified the negative effect.Originality/valueThe authors address the void of the cross-level mediating process by examining the role of individual work engagement that mediates relationship conflict and individual job performance. The individual work engagement is highlighted in this study for the hope of serving as the basis of finding effective moderators to alleviate the negative relationship conflict–performance relationship by mitigating the decrease of work engagement. Moreover, the claim that the role of emotion from different status subjects varies in regulating the effect of relationship conflict contributes to the development of positive psychology by combining emotion with conflict management.
Network, reputation, VC-financing: SME in Zhongguancun and Silicon Valley
Authors: Trunina Anna , Liu Xielin , Hafeez Muhammad , Chen Jian , Sarker Swati Anindita 
Published: December 2019

Purpose
This paper aims to investigate if the collaboration intensity of the company with local and international stakeholders facilitates the attracting of venture capital (VC) financing. The reputation of the company was incorporated as a factor, which can potentially influence investment decision-making. The study also aims to make a cross-national comparison of new ventures financing in two innovation regions – Chinese Zhongguancun and American Silicon Valley.

Design/methodology/approach
Quantitative methodology involving data gathered from 176 venture-backed as well as non-venture backed SME located in Chinese Zhongguancun and American Silicon Valley was applied. The data has been gathered through a survey. A logistic regression model has been adopted to test the hypotheses and explore relationships among concerned variables.

Findings
The results spotlight that collaboration intensity with the company’s domestic stakeholders could enhance the attractiveness of the company for external investments. Collaboration intensity with foreign stakeholders increases the likelihood of acquiring financial support only for Chinese companies. For American companies, the reputation of their stakeholders did not show a significant effect. However, positive reputation acquired from the Chinese company’s stakeholders enhances the chance of getting funding and moderates the investment effect of collaboration intensity with domestic stakeholders.

Originality/value
This paper unfolds that the network strength and the reputation of the SME could play the role in getting VC investment. The results are shown in two different contexts (Silicon Valley in the USA and Zhongguancun in China), characterizing the completely different cultural, legal, institutional and operating environments.
A reflection on borrowing from western economics
Authors: Fang Fuqian 
Published: December 2019

Purpose
Western economics came into being with the rise of the capitalist market economy. It had a nature of duality beginning from its birth: the justificativeness of providing theoretical pillars for the capitalist market economy system and the scientificity of revealing the internal relations and operating rules of the capitalist market economy. The paper aims to discuss this issue.

Design/methodology/approach
However, after the 1830s, this justificativeness gradually evolved into vulgarity. Since the 1930s, modern western mainstream economics has mainly explored the general market economy on the assumption that the capitalist system remains unchanged, and many outcomes of such research are positive and beneficial.

Findings
Political economy of socialism with Chinese characteristics, at the present stage, is mainly a Chinese socialist market economics. It is guided by the Marxist political economy and rooted in the great practice of China’s reform and opening up and socialist modernization.

Originality/value
According to political complexion, western economic theories can be divided into political economic theory, mainstream economic theory and basic economic theory. By subjecting these theories to what we term “elimination,” “transformation” and “transplantation” surgeries, respectively, we can absorb and accommodate their beneficial elements in building a political economy of socialism with Chinese characteristics, which in turn is conducive to the development and prosperity of such an economy.
CIAC: Adoptando estrategias en el postconflicto
Authors: Hernández Juan Dario , Calderón Juan Camilo , Rodríguez Iván Felipe , Bayona Jaime Andrés 
Published: December 2019

Learning outcomes
1. Identificar la influencia de variables contextuales (i.e. políticas) en la estrategia de una organización militar. 2. Analizar y evaluar opciones de cambio estratégico de una organización militar. 3. Decidir un cambio estratégico desde el modelo de recursos y capacidades.

Case overview/synopsis
La CIAC es una compañía colombiana de economía mixta que tiene como objetivo comercializar servicios de mantenimiento y reparación de aeronaves y componentes aeronáuticos civiles y militares. El caso presenta la decisión que debe tomar su gerente con respecto al cambio de estrategia corporativa debido a la entrada en vigencia del acuerdo de paz entre el Gobierno de Colombia y las Fuerzas Armadas Revolucionarias de Colombia (FARC). Este acuerdo supone que la principal línea de negocio de la CIAC se debilitaría (i.e. reparación de aeronaves militares utilizadas en el conflicto con las FARC), pues dentro de un nuevo escenario de paz, las aeronaves no necesitarían tanto mantenimiento como en las etapas más críticas del conflicto.

Complexity academic level
MBA (cursos sugeridos: Estrategia, Dirección estratégica, Cambio organizacional). Pregrado (cursos sugeridos: Estrategia, Cambio organizacional).

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 11: Strategy.
Disentangling the strength of the HRM system: effects on employees reactions
Authors: de la Rosa-Navarro Dolores , Díaz-Fernández Mirta , Lopez-Cabrales Alvaro 
Published: December 2019

Purpose
A strong HRM system (encompassing the dimensions of distinctiveness, consistency and consensus) facilitates a collective interpretation of Human Resource Management (HRM) practices in a common direction, and consequently, a conjoint response by employees. The purpose of this paper is two fold: first to argue that those dimensions have a direct impact on the reaction of employees (organisational citizenship behaviour, OCB and intention to remain, IR); and second, the authors propose that these dimensions are not independent, but rather can interact in such a way that consensus impacts on the consistency of an HRM system, and consistency mediates the relationship between consensus and OCB and IR.

Design/methodology/approach
The authors surveyed HR managers and employees from a sample of 102 Spanish hotels. Specifically, HR managers were asked to complete a questionnaire assessing the dimensions of HRM strength, and employees completed a different questionnaire reporting their levels of OCB and IR. The authors examined the reliability and validity of measures by means of Confirmatory Factor Analysis. Finally, structural equations models were applied to test direct effects and mediating hypotheses.

Findings
As an initial finding, the authors obtained two dimensions of HRM strength: consistency and a new factor, which is a combination of distinctiveness and consensus, labelled the “Reputation” of the HRM system. A second result is that such the reputation of the HRM system positively affects OCB and IR. Third, consistency mediates in the relationships between the reputation of the HRM system and OCB and IR.

Research limitations/implications
Although the authors are aware of the limitations of our paper, regarding the cross-sectional data design and the assessment of HR strength by managers, the authors believe that the results highlight the importance of HRM system strength, since it affects individual outcomes.

Originality/value
One of the valuable contributions made by this paper is that the authors obtained two dimensions for HRM strength instead of the three proposed by Bowen and Ostroff (2004): consistency and reputation (as a combination of distinctiveness and consensus). The authors explain that the new dimension is related to the concept of employer branding, emphasising HRM system’s internal image, facilitating common expectations that guide employees towards the desired responses. Second, Reputation impacts Consistency, improving employees’ OCB and IR; hence, the dimensions of HRM system strength are not independent, but they are better able to interact in order to affect employee outcomes.
“These kids are rebelling”: a student-led transformation of community and critical literacy
Authors: Shelton Stephanie Anne , Guy Kelsey H. , Jones April M. 
Published: December 2019

Purpose
This paper aims to consider the ways that students are shaped by and shape community and critical literacy, along with the ways that community affords student empowerment in an English class during a US high school summer enrichment program.

Design/methodology/approach
The qualitative methodological approach is a narrative-based descriptive case study. To provide a detailed and narrative-based discussion, the authors incorporate ethnographic observation narratives and conversational interview excerpts, and analyze the data through inductive coding.

Findings
Organizing the findings into two sections, “These kids are rebelling”, and “We’re trusting him to teach and do better now”, we first examine the ways that student-led rebellion reshaped the classroom community and then the ways that the teacher's response redefined critical literacy approaches and his interactions with the students.

Research limitations/implications
As this is a qualitative case study that is set during a summer enrichment program, its implications are not wholly generalizable to secondary English education. However, this research does suggest the importance of student agency in considerations of community and critical literacy.

Practical implications
This research emphasizes the importance of acknowledging and exploring ways that students' everyday interactions and agency shape educational spaces. Additionally, this research suggests the importance of community and critical literacy to all teachers, no matter their levels of experience or success.

Social implications
Students have tremendous potential to not only shape and define learning environments, but to transform pedagogy and teacher relationships. This research emphasizes the importance of acknowledging and exploring these implications specifically to transform community and critical literacy in a summer high school English classroom.

Originality/value
First, this paper examines student community as an agentive and rebellious influence within the everyday constructs of schooling, and the authors assert that critical literacy pedagogies may be student-driven as part of community-based activism. Second, this paper seeks to explore both “community” and “critical literacy” as key concepts in positioning students as influential and empowered stakeholders with capacities to reshape education.
Adaptive information sharing approach for crowd networks based on two stage optimization
Authors: Wang Xiaoni , Pan Zhiwen , Li Zhouxia , Ji Wen , Yang Feng 
Published: December 2019

Purpose
This paper aims to optimize and evaluating the performance of the crowd networks through analyzing their information sharing patterns. That is, in a crowd network, the qualities of accomplishing tasks are highly dependent on the effective information sharing among intelligent subjects within the networks. Hence, proposing an adaptive information-sharing approach can help improve the performance of crowd networks on accomplishing tasks that are assigned to them.

Design/methodology/approach
This paper first introduces the factors that affect effectiveness of information-sharing pattern: the network topology, the resources owned by intelligent subjects and the degree of information demand. By analyzing the correlation between these factors and the performance of crowd networks, an Adaptive Information Sharing Approach for Crowd Networks (AISCN approach) is proposed. By referring to information needed for accomplishing the historical tasks that are assigned to a crowd network, the AISCN approach can explore the optimized information-sharing pattern based on the predefined composite objective function. The authors implement their approach on two crowd networks including bee colony and supply chain, to prove the effectiveness of the approach.

Findings
The shared information among intelligent subjects affects the efficiency of task completion in the crowd network. The factors that can be used to describe the effectiveness of information-sharing patterns include the network topology, the resources owned by intelligent subjects and the degree of information demand. The AISCN approach used heuristic algorithm to solve a composite objective function which takes all these factors into consideration, so that the optimized information-sharing pattern can be obtained.

Originality/value
This paper introduces a set of factors that can be used to describe the correlation between information-sharing pattern and performance of crowd network. By quantifying such correlation based on these factors, this paper proposes an adaptive information-sharing approach which can explore the optimized information-sharing pattern for a variety of crowd networks. As the approach is a data-driven approach that explores the information-sharing pattern based on the network’s performance on historical tasks and network’s characteristics, it is adaptive to the dynamic change (change of incoming tasks, change of network characteristics) of the target crowd network. To ensure the commonality of the information-sharing approach, the proposed approach is not designed for a specific optimization algorithm. In this way, during the implementation of the proposed approach, heuristic algorithms can be chosen according to the complexity of the target crowd network.