bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid and complete inactivation of SARS-CoV-2 by ultraviolet-C irradiation
Authors: Storm Nadia , McKay Lindsay , Downs Sierra , Johnson Rebacca , Birru Dagnachew , de Samber Marc , Willaert Walter , Cennini Giovanni , Griffiths Anthony 
Published: September 2020

Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has devastated global public health systems and economies, with over 23 million people infected, millions of jobs and businesses lost, and more than 800 000 deaths recorded to date. Contact with surfaces contaminated with droplets generated by infected persons through exhaling, talking, coughing and sneezing is a major driver of SARS-CoV-2 transmission, with the virus being able to survive on surfaces for extended periods of time. To interrupt these chains of transmission, there is an urgent need for devices that can be deployed to inactivate the virus on both recently and existing contaminated surfaces. Here, we describe the inactivation of SARS-CoV-2 in both wet and dry format using radiation generated by a commercially available Signify ultraviolet (UV)-C light source at 254 nm. We show that for contaminated surfaces, only seconds of exposure is required for complete inactivation, allowing for easy implementation in decontamination workflows.
Correlation Between Nutritional Deficit and the Presence of Depressive Symptoms: Comparative Study Between Elderly Brazilians and Portuguese in Primary Health Care
Authors: Toscano Gislani Acásia da Silva , Cavalcante Anna Carolynna Vieira , Torres Neidjany Patrícia Lima , Miranda Jéssica Maria Arouca de , Dantas Bruno Araújo da Silva , Jacinto Maria Angélica Gomes , Torres Sandra Maria da Solidade Gomes Simões de Oliveira , Nobre Thaiza Teixeira Xavier , Maia Eulália Maria Chaves , Mendes Felismina Rosa Parreira , Miranda Francisco Arnoldo Nunes de , Torres Gilson de Vasconcelos 
Published: September 2020

Abstract
Background: Among the countless diseases that affect the world population, malnutrition has stood out in several social and demographic contexts; among them, there has been an exponential progression in elderly people, a population group that presents a strong tendency to develop depression and malnutrition. Data from the World Health Organization show that the worldwide prevalence of depressive disorders among elderly people is in the range of 10 to 20%. Similarly, the prevalence of depression, in turn, combined with chronic diseases, accounts for 50% of premature mortality.Objective: To compare the nutritional status and the level of depressive symptoms and to evaluate the correlation between both aspects in Brazilian and Portuguese elderly people assisted in Primary Health Care (PHC).Methods: A cross-sectional, comparative study with a quantitative approach conducted among PHC elderly people in Brazil and Portugal. The sociodemographic and health questionnaire, Mini-Mental State Examination (MMSE), Geriatric Depression scale (GDS-15) and Mini-Nutritional Assessment (MNA) were used.Results: We included 160 participants (110 Brazilians and 50 Portuguese) in the study. In this sample, 81.9% of participants had a risk of malnutrition or malnutrition and 45.0% of participants had mild depressive symptoms. There was a significant association and correlation in Brazil with the presence of a risk of malnutrition and mild symptoms of depression. Portugal also demonstrated a significant association, however, for the chance of not presenting alterations.Conclusion: Our research showed that the risk of malnutrition or the presence of malnutrition was associated with the presence of depressive symptoms in the studied sample. In the intergroup comparison, among Brazilians, those at risk of malnutrition were more likely to have changes associated with depression, while for participants in Portugal, the odds ratio tended to show no changes, as the majority were individuals without nutritional or depressive demands. Screening and prevention measures should be emphasized in PHC to avoid the progression of symptoms in order to refer patients with medium and high complexity since this segment of the public is susceptible to malnutrition and depression.
Electricity Generation and Pollutants Removal of Landfill Leachate by Osmotic Microbial Fuel Cells with Different Forward Osmosis Membranes
Authors: Jiang Nan , Huang Li , Cai Teng , Song Jialing , Zheng Shengyang , Guo Jili , Kong Zhuang , Manhong Huang 
Published: September 2020

Abstract
In this study, thin-film composite with embedded polyester screen (TFC-ES), cellulose triacetate with a cast nonwoven (CTA-NW) and cellulose triacetate with embedded polyester screen (CTA-ES) were examined as the intermediate membranes in osmotic microbial fuel cells (OsMFCs). The reactors were fed with actual landfill leachate and the performance was studied in two operation modes: active layer facing draw solution (AL-DS) and active layer facing feed solution (AL-FS). The OsMFC with CTA-ES exhibited the best energy generation (maximum power density: 0.44 W•m-2) and pollutant removal efficiency (ammonia nitrogen: 70.12 ± 0.28%, total nitrogen: 74.04 ± 0.33%) in the AL-FS mode, which could be ascribed to the lowest internal resistance (236.75 ohm) and highest microbial richness. Pseudomonas was the highest proportion of microbial in OsMFCs. The results of this study has demonstrated the potential of OsMFCs for landfill leachate treatment.
A Systematic Review of the Correlation Between Web-based Query and Outbreak of Emerging Infectious Diseases and Meta-analysis of Influenza-like Illnesses
Authors: Nguyen-Tran Minh-Duc , Nguyen-Tran Nu-Vuong , Phuc Nguyen Nhu Do , Tran Huu Loc Thai , Zayan Ahmad Helmy , Abdelrahman Ahmed Saber , Vu Thao Thanh , Nguyen Khuong An Luu , Nguyen Trang Thi , Vo Y Nhi Le , Chu Nhat Minh Nguyen , Tran Quynh Thuy Huong , Pham My Hoan , Vu Hai Ngoc , Huy Nguyen Tien 
Published: September 2020

Abstract
Background: Emerging infectious diseases (EIDs) are among the widespread everchanging threats to public health. Web-based queries using information gathered from social media can enhance global syndromic surveillance to trace EIDs activity. This systematic review aimed to investigate the correlation of web-based queries to outbreak of EIDs. Methods: Nine electronic databases were systematically searched and updated in August 2018 including; PubMed, Virtual Health Library (VHL), WHO Global Health Library (GHL), Scopus, ISI, Google Scholar, POPLINE, and Systems for Information of Grey Literature in Europe (SIGLE), New York Academy of Medicine (NYAM Grey Literature Report). A prior protocol was registered at Prospero (CRD42016038104). In a total five included articles, 47 datasets were included for reviewing. The correlation was assessed through Spearman and Pearson tests using either google trends or number of tweets. Results: Meta-analysis of influenza-like illness data revealed that correlation was significant (0.784 (0.743-0.820, 0.964 (0.918-0.985) for both Spearman and Pearson tests respectively. Conclusions: Web-based surveillance systems could serve as a good method in predicting events of EIDs.
Does substrate colour affect the visual appearance of gilded medieval sculptures? Part II: Study of medieval gold leaf
Authors: Wu Qing , Döbeli Max , Lombardo Tiziana , Schmidt-Ott Katharina , Watts Benjamin , Nolting Frithjof , Ganz David 
Published: September 2020

Abstract
In the previous paper (Part I), the colorimetry and interferometric microscopy measurements on modern gold leaf models have revealed that the visual appearance of a gilded surface, both burnished and unburnished, depends strongly on the substrate type, surface roughness and texture, but not on the colour of the substrate. In this second part, we investigate the materials compositions and technical specifications of medieval gold leaf through combining literature sources and materials analysis such as scanning electron microscopy coupled with energy dispersive X-ray analysis (SEM-EDX) on samples taken from gilded artefacts. Our study shows that the late medieval gold leaf has a high purity of about 23.7 carat and has an average thickness of 160 nm (with a peak value of 138 nm), purer and thicker than the modern gold leaves studies in Part I. Supportive Rutherford backscattering spectrometry (RBS) measurements on gilded models confirms the accuracy and reliability of the SEM-EDX observations on the medieval gold leaf samples. We additionally present observations of a rarely recorded special variant of medieval gold leaf – “fine reinforced gold leaf”. Combined with the findings from Part I, we conclude that light penetrating the medieval gold leaf and reflected from the substrate could not be a significant, or even perceptible contribution to the visual appearance of the gilding. We argue that the misconception surrounding the correlation between the substrate colour and the gilded surface appearance can be attributed to the historical development of gilding and polychromy technologies.
Suppression of TCAB1 Expression Induced Cellular Senescence by Lessening Proteasomal Degradation of p21 in Cancer Cells
Authors: Niu Jing , Gao Rui-Qi , Cui Meng-Tian , Zhang Chen-Guang , Li Shen-Tao , Cheng Shan , Ding Wei 
Published: September 2020

Abstract
Background: TCAB1, a.k.a. WRAP53β or WDR79, is an important molecule for the maintenance of Cajal bodies and critically involved in telomere elongation and DNA repair. Upregulation of TCAB1 were discovered in a variety types of cancers. However, the function of TCAB1 in tumor cell senescence remains absent. Methods: The TCAB1 knockdown cell lines were constructed. The expression levels of TCAB1, p21, p16 and p53 were detected by qRT-PCR and western blotting. Staining of senescence-associated β-galactosidase was used to detect senescent cells. The ubiquitination of the p21 was analysed by immunoprecipitatation and in vivo ubiquitination assay. TCGA databases were employed to perform in silico analyses for the mRNA expression of TCAB1, p21, p16 and p53. Results: Here, we discovered that knockdown of TCAB1 induced rapid progression of cellular senescence in A549, H1299 and HeLa cells. In exploiting the mechanism underlining the role of TCAB1 on senescence, we found a significant increase of p21 at the protein levels upon TCAB1 depletion, whereas the p21 mRNA expression was not altered. We verified that TCAB1 knockdown was able to shunt p21 from proteasomal degradation by regulating the ubiquitination of p21. In rescue assays, it was demonstrated that decreasing the expression of p21 was able to attenuate the cellular senescence process induced by TCAB1 silencing. Conclusions: This study revealed the importance of TCAB1 for its biological functions in the regulation of cell senescence. Our results will be helpful to understand the mechanisms of senescence in cancer cells, which could provide clues for designing novel strategies for developing effective treatment regimens.
Predictive Value of A Novel lncRNA LINC02518 in Evaluating the Prognosis of Patients With Hepatocellular Carcinoma
Authors: Cui Wei , Huang Jingzhi , Wang Ruiqi , Wang Yu , Chen Xiaoming , Shi Feng , Li Jiaping , Xu Rongde 
Published: September 2020

Abstract
BACKGROUND: The potential of lncRNA in hepatocellular carcinoma (HCC) has led to promising insights in therapeutic intervention. The clinical significance of LINC02518 in HCC is unclear. This study aimed to evaluate the predictive value of a novel long non-coding RNA LINC02518 for the prognosis of patients with HCC. METHODS: Between December 2005 and November 2011, 125 HCC patients in training group and 75 HCC patients in validation group who underwent liver surgery were involved in our study. The LINC02518 expression of HCC and corresponding non-tumor liver tissues was detected by microarray and qRT-PCR. These HCC patients were divided into high and low LINC02518 expression groups based on the threshold of the receiver operating characteristic curve. Kaplan-Meier analysis was performed to determine the prognosis of HCC patients.RESULTS: LINC02518 expression was upregulated in paired tumor samples compared to that in corresponding non-tumor samples in two groups. The areas under the receiver operating characteristic curve for the levels of LINC02518 in the diagnosis of HCC was 0.66, 95% CI: 0.59–0.73. HCC patients with high LINC02518 expression had significantly worse tumor recurrence-free, metastasis-free, disease-free, and overall survival than those with low LINC02518 expression.CONCLUSIONS: LINC02518 is negatively correlated with the prognosis of HCC and provides a promising strategy for the treatment and prognosis of HCC.
Investigating Metalinguistic Written Corrective Feedback Focused on EFL Learners' Discourse Markers Accuracy in Mobile-mediated Context
Authors: Pourdana Natasha , Nour Payam , Yousefi Fariba 
Published: September 2020

Abstract
Among a growing body of research that examined the contradictory role of written corrective feedback (WCF) in development of L2 writing accuracy, this study investigated the possible impact of focused metalinguistic WCF on discourse markers (DMs) in writing performance of an intact group of 42 Iranian English as a Foreign Language (EFL) learners over an eight-week period. In an authentic, situated, and personalized learning platform, giving and receiving WCF were made possible only through the mobile-mediated application of WhatsApp. Before participants wrote on selected elicitation topics, they had taken part in a 2004 version of Oxford Preliminary Test in order to be screened for their initial differences in writing performance. After receiving metalinguistic WCF on their scripts, participants were required to work on the coded feedback and try to eliminate the DM errors in their revised writing assignment. After collecting the scripts over an eight-week period, the content of written assignment was thematically analyzed using NVivo 21 Software for the additive, adversative, causal and temporal DMs, following Halliday and Hasan’s (1976) typology. In a convergent mixed-methods design, the content analysis of the qualitative data showed a larger distribution of additive DM than adversative, causal, and temporal DMs in all participants’ written scripts. Exploring the possible impact of metalinguistic WCF on improving the DMs accuracy, analysis of the frequency count data with (Statistical Package for the Social Sciences) SPSS multivariate Chi-square test reported the fluctuating and unsystematic patterns of distribution for four types of DMs with no sign of significant long-term improvement in DMs accuracy after receiving metalinguistic WCF. These findings implied further research on practicing alternative WCF strategies focused on variety of error types in actual and virtual L2 writing environment.
Determinants of Modern Family Planning Methods in the Oromia, Amhara, and Somali Regions, Ethiopia: A Community-Based, Cross-Sectional Mixed Methods Study
Authors: Lee Hocheol , Kindane Eshetu Girma , Doh Young Ah , Nam Eun Woo 
Published: September 2020

Abstract
Background: In 2019, Ethiopia had a total fertility rate of 4.2 births per woman with the rates varying significantly across regions. The Federal Ministry of Health of Ethiopia announced “Ethiopia FP 2020” to address the high fertility rate, aiming to reduce it to 3.0 by 2020. This study aimed to identify the determinants of the use of modern family planning services in the Amhara, Oromia, and Somali regions.Methods: A community-based, cross-sectional mixed methods study was conducted, using quantitative and qualitative data. The quantitative data were subjected to binary logistic regression analyses. Participants included over 4,117 married men and women aged 15-65 years old.Results: Respondents in Oromia were 8.673 times more likely to have modern family planning methods than those in Somali. Participants in Amhara were 5.183 times more likely to have modern family planning methods than their Somali counterparts. Women, married respondents, and recipients of media messages were more likely to have family planning experience. Family planning discussions with Health Extension Workers and health professionals played a significant role in modern family planning. Conclusion: Establishing a family planning strategy that considers the sociocultural characteristics of each region might help address regional contexts. Everyone in Somali—especially husbands and religious leaders—must be educated in family planning and funds be made available to deploy advanced measures for the same.
CSF biomarker profiles in CNS infection associated with HSV and VZV mimic pattern in Alzheimer’s disease.
Authors: Shinomoto Makiko , KASAI TAKASHI , Tatebe Harutsugu , Kitani-Morii Fukiko , Ohmichi Takuma , Fujino Yuzo , Allsop David , Mizuno Toshiki , Tokuda Takahiko 
Published: September 2020

Abstract
Background: Central nervous system (CNS) infections have been reported to have a certain etiological relevance to Alzheimer’s disease (AD). In particular, herpes simplex virus (HSV) and varicella zoster virus (VZV) infections has been reported as risk factors for AD. The aim of this study was to determine whether or not AD-related biomarkers were changed in patients with HSV or VZV CNS infections.Methods: Nine patients with HSV infection of the CNS, eight patients with VZV complicated by CNS involvement, and eighteen age-matched controls were enrolled. Amyloid β (Aβ)1-42, Aβ1-40, total-tau (t-tau), tau phosphorylated at threonine 181 (p-tau), neurofilament light chain (NfL), phosphorylated neurofilament heavy chain (p-NfH), glial fibrillary acidic protein (GFAP), and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in were measured in cerebrospinal fluid (CSF), and NfL in serum.Results: Compared with the control group, CSF Aβ1-42, Aβ1-40, and the Aβ1-42/ Aβ1-40 ratio were significantly decreased, and CSF t-tau, p-tau, sTREM2, and GFAP were significantly increased in the HSV and VZV combined group, in which biomarker changes were similar to those reported in AD. CSF NfL levels measured on admission were significantly correlated with the disease severity and a poor outcome after age adjustment. Serum NfL on admission was also associated with disease severity after age adjustment.Conclusions: The fact that the biomarker profile in patients with CNS HSV and VZV infections mimicked that in AD patients should be paid attention to as a potential confounding factor in CSF biomarker-based diagnosis of AD, and it suggests an etiological similarity between herpetic virus infection and AD. The CSF NfL concentration on admission may be useful as a predictive marker of severity and prognosis in patients with CNS HSV and VZV infections.
Computerized Cognitive Training in People with Depression: A Protocol for a Systematic Review and Meta-Analysis
Authors: Lampit Amit , Launder Nathalie H , Minkov Ruth , Rollini Alice , Davey Christopher G , Finke Carsten , Lautenschlager Nicola T , Gavelin Hanna Malmberg 
Published: September 2020

Abstract
Background
People with depression often present with concurrent cognitive impairment. Computerized cognitive training (CCT) is safe and efficacious strategy to maintain or enhance cognitive performance in a range of clinical populations. However, its efficacy in people with depression and how it varies across populations and design factors is currently unclear.
Methods
We searched MEDLINE, EMBASE and PsycINFO from inception to 29 June 2020 for randomised controlled trials examining the efficacy of CCT vs any control condition on cognitive, mood, psychiatric symptoms, psychosocial functioning and daily function in adults with depression. Eligible samples include studies specifically targeting people with major depressive disorder as well as those with other diagnoses where at least 50% of the sample meets clinical criteria for depression, with the exception of major psychiatric disorders or dementia. The primary outcome is change in overall cognitive performance. Multivariate analyses will be used to examine effect sizes on each outcome category as well as possible effect modifiers and correlations between categories. Risk of bias will be assessed using the Cochrane risk of bias tool version 2.
Discussion
To the best of our knowledge, this will be the first systematic review and meta-analysis of narrowly-defined CCT across clinical populations with depression. We aim to investigate not only whether CCT is efficacious for cognition, but also how such effects vary across design factors, what other clinically relevant outcomes might respond to CCT and the extent to which they differ across populations.
Systematic review registration:
Submitted and pending evaluation with PROSPERO.
Transcriptional Expression of Secondary Resistance genes ccdB and repA2 is Enhanced in Presence of Cephalosporin and Carabapenem in Escherichia Coli
Authors: Baishya Somorita , Deshamukhya Chandrayee , Wangkheimayum Jayalaxmi , Das Bhaskar Jyoti , Anbarasu Anand , Talukdar Anupam Das , Bhattacharjee Amitabha , Choudhury Manabendra Dutta 
Published: September 2020

Abstract
Background: The issue of carbapenem resistance in E.coli is very concerning and it is speculated that cumulative effect of both primary resistance genes and secondary resistance genes that act as helper to the primary resistance genes are the reason behind their aggravation. Therefore, here we attempted to find the role of two secondary resistance genes (SRG) ccdB and repA2 in carbapenem resistance in E. coli (CRE).Methods: Influential genes belonging to secondary resistome that act as helper to the primary resistance genes like blaNDM and blaCTX-M in aggravating β-lactam resistance were selected from an earlier reported in silico study. Transcriptional expression of the selected genes in clinical isolates of E.coli that were discretely harboring blaNDM-1, blaNDM-4, blaNDM-5, blaNDM-7 and blaCTX-M-15 with and without carbapenem and cephalosporin stress (2µg/ml) was determined by real time PCR. Cured mutants sets that were lacking (i) primary resistance genes, (ii) secondary resistance genes and (iii) both primary and secondary resistance genes were prepared by SDS treatment. These sets were then subjected to antibiotic susceptibility testing by Kirby Bauer disc diffusion method.Results: Out of the 21 genes reported in the in silico study, 2 genes viz. repA2 and ccdB were selected for transcriptional expression analysis. repA2, coding replication regulatory protein, was downregulated in response to carbapenems and cephalosporins. ccdB, coding for plasmid maintenance protein, was also downregulated in response to carbapenems except imipenem and cephalosporins. Following plasmid elimination assay increase in diameter of zone of inhibition under stress of both antibiotics was observed as compared to uncured control hinting at the reversion of antibiotic susceptibility by the-then resistant bacteria. Conclusion: SRGs repA2 and ccdB help sustenance of blaNDM and blaCTX-M under carbapenem and cephalosporin stress.