bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes Mellitus Complications and Associated Factors Among Adult Diabetic Patients in Selected Hospitals of West Ethiopia
Authors: Korsa Ayana Tadesse , Genemo Edao Sado , Bayisa Habte Gebeyehu , Dedefo Mohammed Gebre 
Published: January 2020

Background / Introduction:
The prevalence of type 1 and type 2 diabetes mellitus (DM) is increasing worldwide. The prevalence might even be higher in low-income countries. As a result, type 1 and type 2 DM and their complications are imposing a high burden on patients (e.g. hospitalization, disability and death). In Ethiopia, there are limited studies focusing on the complications of type 1 and type 2 DM. Thus, we assessed the prevalence of type 1 and type 2 DM complications and associated factors in selected hospitals in western Ethiopia.

Methods:
This cross-sectional study included 257 adult patients with DM attending the chronic care clinics of Nedjo general and Nekemte referral hospitals. The study was carried out between March 1 and April 30, 2016 using a pre-tested self-administered questionnaire and chart review.

Results:
Of the 257 patients, 87 (33.9%) had ≥1 DM complication. Acute and chronic complications accounted for 9.3% and 24.5% of the total DM patients, respectively. The age of the patients (p=0.024), family history of DM (p=0.038), DM duration (p=0.015), DM regimen (p=0.041), and the occurrence of other chronic diseases (p=0.006) were significantly associated with DM complications.

Conclusion:
The findings of this study revealed that 1 out of 3 adults with DM have ≥1 complication in our chronic ambulatory care clinics. Diabetic keto-acidosis was the most common acute complication whereas hypertension was the most common chronic complication. The presence of DM complications was associated with the age of the patients, duration of DM, family history of DM, DM regimen and the presence of other chronic diseases.
Metagenomic Assessment of Different Interventions for Treatment of Chronic Periodontitis: A Systematic Review and Meta-Analysis
Authors: Alblowi Jazia A. , Gamal-Abdel Naser Ayat 
Published: January 2020

Background:
Chronic periodontitis is attributed to oral microbial imbalance and host inflammatory reaction.

Objective:
Our review addresses the question of: Are the available interventions able to regain oral microbial balance in patients having chronic periodontitis?

Data Sources:
We performed a comprehensive systematic search of MEDLine via Pubmed, Cochrane CENTRAL, Clinicalkey, Clarivate Analytics, Springer materials, Wiley, SAGE, Elsevier, Taylor & Francis group, and Wolter Kluwer, together with hand searching and searching the grey literature.

Eligibility Criteria:
We included interventional studies testing the microbiome analysis using metagenomic techniques as an outcome to any intervention for chronic periodontitis.

Study Appraisal and Synthesis Methods:
All studies were imported in Mendeley. The risk of bias was assessed using the specific tool for each study design. The results were analysed using RevMan. All the review steps were performed in duplicates.

Results:
The search yielded 2700 records. After exclusion steps, 10 records were found eligible. We included 5 RCTs, 1 non-RCT, 3 before-and-after studies, and 1 ongoing study. The studies tested non-surgical periodontal treatment with and without antibiotic coverage, probiotics, sodium hypochlorite rinse, and different toothpaste ingredients. One RCT tested the use of enamel matrix derivatives in cases with furcation involvement.

Limitations:
The eligible available studies were small in number. Also, the risk of bias and lack of a standardized protocol impaired the ability to pool all the results.

Conclusions:
The body of the available evidence is not sufficient, and future studies are recommended to better evaluate the effect of periodontal treatments on the periodontal microbiome.
Chemical Composition and Antimicrobial Activity of Essential Oil and Hydrosol Extract From Roots of Plumbago europaea and in-vitro Combinatory Antimicrobial Effect of Hydrosol Extract with Gentamicin and Amphotericin B
Authors: Kaddour Faiza , Aissaoui Nadia , Dib Mohammed El Amine , Bensaid Okkacha , Muselli Alain 
Published: January 2020

Background:
Infectious diseases are responsible for millions of deaths a year worldwide.
Antibiotics, which have saved so many lives and improved life expectancy, may become ineffective
due to a worrying increase in bacterial resistance. Some of the appropriate actions that could be initiated
to address this problem are to develop and search for new antimicrobial substances from medicinal
plants, and combine antibiotics with antimicrobials agents isolated from a reservoir of bioactive
natural products.

Objectives:
The purpose of this work was to study the chemical composition of the essential oil and hydrosol extract of Plumbago europaea, to evaluate their in-vitro antimicrobial activities and evaluate in-vitro combinatory antimicrobial effect of hydrosol extract with Gentamicin and Amphotericin B against a large panel of microorganisms in an effort to reduce their minimum effective dose and minimizing their side effects.

Methods:
The essential oil and hydrosol extract obtained from roots of Plumbago europaea were analyzed by GC/MS and tested for their antibacterial and antifungal activities against twelve different strains of microorganisms. The effectiveness, in-vitro, of the association between the hydrosol extract and both Gentamicin and Amphotericin B was also investigated using the checkerboard method.

Results:
The obtained results revealed that nine and four components, representing for 92.4 % and 97.4% of the total essential oil and hydrosol extract composition were identified, respectively and hydrosol extract was more active than the essential oil against all screened microorganisms, with interesting MIC values (19 μg/mL). An important effect of hydrosol extract was obtained in decreasing the MIC of Gentamicin and Amphotericin B in all tested combinations.

Conclusion:
The in-vitro combination of the hydrosol extract with Gentamicin and Amphotericin B led to substantial MIC reduction against all tested microorganisms. This combination can help to reduce the minimum effective dose of antimicrobial drugs used, which may help to decrease their side effects; and deliver these medicines with similar potency.
شرۆڤەكردنى ڕستەى زمانى كوردى لە ڕوانگەى تيۆرى دەسەڵات و بەستنەوەدا
Authors: Qadir Abubakir Omar 
Published: January 2020

This study tries to analyze the Kurdish language, using Chomsky’s (1981) Government Binding theory, which is by itself regarded as a turning point in Chomsky’s Transformational Generative Grammar related to Universal Grammar. This approach will answer the diversity occurs in different languages according to Principles and Parameters.
First, Universal Grammar and its principles have been mentioned in this study. Later on, interpretations are given to the sub-theories of GB with which sentences in central Kurdish are analyzed. Besides, the level and method of the theory a long with the optional and obligatory movements are shown. Interpretations are given to different cases of noun phrase. The difference between grammatical case and theta role is indicated through examples.Again, indicating economy in expression, movement and null-constituents whose places can be filled by PRO/ pro are discussed. The distribution of pronouns to personal and demonstrative which refer back to the empty categories reveals the activeness of Kurdish as a pro-drop language.
Effectiveness and Cost-Effectiveness of Receiving a Hearing Dog on Mental Well-Being and Health in People With Hearing Loss: Protocol for a Randomized Controlled Trial
Authors: Stuttard Lucy , Hewitt Catherine , Fairhurst Caroline , Weatherly Helen , Walker Simon , Longo Francesco , Maddison Jane , Boyle Philip , Beresford Bryony 
Published: January 2020

Background
People with hearing loss, particularly those who lose their hearing in adulthood, are at an increased risk of social isolation, mental health difficulties, unemployment, loss of independence, risk of accidents, and impaired quality of life. In the United Kingdom, a single third-sector organization provides hearing dogs, a specific type of assistance dog trained to provide sound support to people with hearing loss. These dogs may also deliver numerous psychosocial benefits to recipients. This has not previously been fully investigated.

Objective
The study aims to evaluate the impact of a hearing dog partnership on the lives of individuals with severe or profound hearing loss.

Methods
A 2-arm, randomized controlled trial will be conducted within the United Kingdom with 162 hearing dog applicants, aged 18 years and older. Participants will be randomized 1:1 using a matched-pairs design to receive a hearing dog sooner than usual (intervention arm: arm B) or to receive a hearing dog within the usual timeframe (comparator arm: arm A). In the effectiveness analysis, the primary outcome is a comparison of mental well-being 6 months after participants in arm B have received a hearing dog (arm A have not yet received a hearing dog), measured using the Short Warwick Edinburgh Mental Well-Being Scale. Secondary outcome measures include the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and Work and Social Adjustments Scale. An economic evaluation will assess the cost-effectiveness, including health-related quality-adjusted life years using the EuroQol 5 Dimensions and social care–related quality-adjusted life years. Participants will be followed up for up to 2 years. A nested qualitative study will investigate the impacts of having a hearing dog and how these impacts occur.

Results
The study is funded by the National Institute for Health Research’s School for Social Care Research. Recruitment commenced in March 2017 and is now complete. A total of 165 participants were randomized. Data collection will continue until January 2020. Results will be published in peer-reviewed journals and at conferences. A summary of the findings will be made available to participants. Ethical approval was received from the University of York’s Department of Social Policy and Social Work Research Ethics Committee (reference SPSW/S/17/1).

Conclusions
The findings from this study will provide, for the first time, strong and reliable evidence on the impact of having a hearing dog on people’s lives in terms of their quality of life, well-being, and mental health.

Trial Registration
International Standard Randomised Controlled Trial Number Registry ISRCTN36452009; http://www.isrctn.com/ISRCTN36452009

International Registered Report Identifier (IRRID)
DERR1-10.2196/15452
MICROWAVE ASSISTED SYNTHESIS OF TETRAHYDROPYRMIDINE AND IN SILICO SCREENING OF ANTIDIABETIC DRUG
Authors: S. GEJALAKSHMI , N. HARIKRISHNAN , E. THILLAI GOVINDARAJAN G. , A. DIVYASRI 
Published: January 2020

Objective: To detect the microwave-assisted synthesis of Tetrahydropyrimidine derivative and its molecular docking studies for Diabetes.
Methods: The Bignelli condensation method was used for Tetrahydropyrimidine derivative synthesis. The docking studies made in Argus Lab software.
Results: The Tetrahydropyrimidine is synthesized using the microwave. The Tetrahydropyrimidine derivative is found to be attack the insulin receptor, as it the tendency of binding with insulin receptor showed in Argus lab. Further, the good binding site of Tetrahydropyrimidine derivative with insulin receptor was predicted.
Conclusion: From the research work, The Tetrahydropyrimidine derivative shows its affinity to bind with the insulin receptor. The binding value is averagely 7 which indicates it can attraction with the receptor, so it can control Diabetic mellitus by altering insulin secretion in blood plasma.
ANTIOXIDANT ACTIVITY AND TOTAL PHENOL AND FLAVONOIDS ANALYSIS OF SIBERIAN GINSENG ROOT
Authors: SHETTY NAGENDAR , HARIKA V. , LOKRAS SUMITRA 
Published: January 2020

Objective: This study was examined to in vitro antioxidant activity and Total Phenol and Flavonoids content analysis of methanolic root extract of Eleutherococcus senticosus (Siberian ginseng).
Methods: 1,1-dephenyl-2-picryl-hydrazyl free radical scavenging and FRAP assay propose that antioxidant activity of methanol root extract because of reducing capacity of the antioxidant against oxidative effects of reactive oxygen species.
Results: Scavenging activity of Siberian ginseng root RC50 value was shown 713.42±11.55 µg/ml and reducing power 0.13±0.01 mmol/g was investigated. In addition, total phenol 12.6±1.13 mg GAE/g DW and total flavonoids 9.8±0.20 mg QE/g DW were recorded.
Conclusion: Although all tests were performed in vitro assay, these results recommend that Siberian ginseng root may be a good source of antioxidant ingrediant.
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS QUANTIFICATION OF SORAFENIB AND REGORAFENIB DRUG SUBTANCES BY USING RP-UPLC
Authors: CHOPPELLA VIDYASAGAR , K. RAGHU BABU , BADIPATI SURESH , GONTHINA HARITHA , CHUKKA VENKATA KISHORE 
Published: January 2020

Objective: The aim of the research work is to develop and validate a novel, sensitive, specific, rapid, accurate, precise and stability indicating gradient reverse phase ultra-performance liquid chromatography (RP-UPLC) method for the quantitative determination of sorafenib and regorafenib drug substances.
Methods: Liquid chromatographic method used for the analysis of the anti-cancer drug substances like sorafenib and regorafenib and method was developed and validated by using efficient chromatographic separation method and was achieved with the use of acquity UPLC system was used consisting of quaternary pump, photodiode array detector an auto injector and on line degasser.
Results: The separation was achieved using acquity UPLC BEH C18, 1.7 µm.2.1×50 mm analytical column at 30 °C employing a gradient elution. Empower software was used for data acquisition. During method validation all the parameters were evaluated as per ICH guidelines, which remained well within acceptable limits. Degradation of the drug substances was found to be stable to acidic, aqueous, basic hydrolysis, thermal hydrolysis and photolytic stress condition and the tests solution of the drug substance was found to be stable up to 24 h.
Conclusion: The results of linearity, precision accuracy and specificity were proved to be within the limits. This method can be employed in routine analysis for simultaneous estimation of sorafenib andregorafenib drug substances in quality formulations and dissolution studies.
LINGUOCULTURAL IDENTITY ASPECTS IN THE PROCESS OF FOREIGN VERBAL TRADEMARKS PERCEPTION AND TRANSLATION
Authors: Glukhova Olga Vladimirovna , Evsyukova Tatyana Vsevolodovna 
Published: January 2020

The paper is a comprehensive interdisciplinary study of verbal trademarks in terms of cultural linguistics, psychological cultural linguistics and cognitive science. The paper considers the verbal trademarks as a distinct linguoculture capable of transmitting cultural values. The study aims to show the way linguocultural identity interrelates with the processes of verbal trademarks perception and localization. The first chapter deals with the concepts of cultural and linguocultural identity. The second chapter discusses the results of associative experiment held in terms of the paper. The experiment involved people of three age groups whose task was to share their associations with the particular verbal trademarks and resulted in a scope of various lexical material. The conceptual and value-based analysis of the data received proved the hypothesis. The last chapter is devoted to the concept of localization in marketing and translation studies. The article points out the cultural value aspects of the process.
Analisis dan perancangan data warehouse evaluasi mahasiswa studi kasus pada jurusan Teknik Informatika UMM
Authors: Maulana Mohammad Agung Alifferiza , S.Kom, M.Kom. Maskur , Soeharso Wildan 
Published: January 2020

AbstrakDalam rangka meningkat kualitas pendidikan secara berkelanjutan diperlukan suatu trobosan yang mampu melakukan analisa proses bisnis yang bertujuan untuk memudahkah eksekutif dalam melakukan pengambilan keputusan. Untuk mengatasi hal tersebut dibangun sebuah data warehouse yang berdasarkan laporan borang akreditasi khusus standard 3 mengenai mahasiswa. Penerapan data warehouse berguna untuk mendukung pengambilan keputusan di tingkat management. Model data warehouse yang di gunakan dalam penelitian ini adalah menggunakan Skema Star, dan menggunakan nine Step Metodology. Dengan pembangunan data warehouse, diharapkan dapat menghasilkan informasi yang berkenaan dengan evaluasi mahasiswa berdasarkan standard akreditasi dengan lebih cepat, sesuai dengan kebutuhan, serta menghasilkan informasi yang lebih ringkas. Dengan menggunakan sistem data warehouse juga dapat dihasilkan analisis multidimensi yang bersifat informasi analitis. Sehingga bermanfaat dalam pengambilan keputusan berkenaan dengan evaluasi mahasiswa.AbstractIn order to improve the quality of education sustainably, a breakthrough is needed. A breakthrough that able to analyze business processes that aim to make the processes itself easier for executives to make decisions. Data warehouse was built to overcome that, based on the report of the third standard special accreditation forms about students. The application of data warehouse is useful to support decision-making at the management level. The data warehouse model used in this study is using Star Scheme and uses the Nine-Step Methodology. With the construction of a data warehouse, it is expected to produce information relating to student evaluations based on accreditation standards more quickly, according to needs, and produce more concise information. Using a data warehouse system can also produce a multidimensional analysis, which is an analytical information. So it can be useful in decision making regarding to the student evaluations.
Universidade Federal Fronteira Sul: uma conquista popular
Authors: Nadaletti Cristiane Letícia 
Published: January 2020

Fazer uma reflexão sobre a história da luta pela universidade no Brasil não é tarefa simples. Tendo como plano de fundo a luta pela criação da Universidade Federal Fronteira Sul, este texto apresenta uma breve sistematização do processo de luta popular que levou a esta conquista. Articulando estes elementos com a crítica ao atual sistema de ensino superior no Brasil, buscamos caminhar no sentido de construir respostas, mesmo que parciais para as seguintes questões: É possível que esta universidade dialogue permanentemente com a sociedade que a constituiu e que lhe dá legitimidade? É possível criar uma universidade que supere o corporativismo e esteja profundamente engajada com a busca de soluções para os grandes problemas da humanidade? É possível criar uma universidade verdadeiramente comprometida com as necessidades da população?
QUESTÃO AGRÁRIA, URBANA E AMBIENTAL NA AMAZÔNIA BRASILEIRA: EXPRESSÕES DA “QUESTÃO SOCIAL” NA REGIÃO
Authors: Nascimento Nádia Socorro Fialho 
Published: January 2020

Este artigo reflete sobre a questão agrária, urbana e ambiental no contexto da Amazônia brasileira, a partir das determinações estruturais e históricas da sociedade do capital. Objetiva destacar que as questões que afetam a região amazônica estão relacionadas ao papel que ela desempenha na totalidade do desenvolvimento capitalista. Isso porque as regiões/nações ricas em recursos naturais como é o caso do Brasil e nele, como caso emblemático, da Amazônia brasileira, são alvo da exploração sobre a natureza em função da importância daqueles recursos para o processo produtivo. Através do exame dos efeitos da implantação de grandes projetos, especialmente os de exploração mineral, sobre o espaço amazônico conclui por afirmar que o privilegiamento do modelo de desenvolvimento, calcado nos grandes projetos econômicos, tem produzido e (re)produzido expressões da "questão social" na região
ABUSOS SEXUAIS NO EMPREGO DOMÉSTICO NO RIO DE JANEIRO: A IMBRICAÇÃO DAS RELAÇÕES DE CLASSE, GÊNERO E “RAÇA”
Authors: Corossacz Valeria Ribeiro 
Published: January 2020

Dans cette article je vais aborder le thème des harcèlements sexuels contre les travailleuses domestiques en utilisant les matériaux tirés de deux recherches conduites à Rio de Janeiro. Dans la première recherche, conduite entre 2009 et 2012, j’ai interviewé 21 hommes de Rio de Janeiro, âgés de 43 à 60 ans, qui s’autodéfinissaient blancs et de classe moyenne supérieure. Dans ces interviews j’ai abordé différents thèmes portant sur les expériences biographiques relatives à la blanchité et à la masculinité (RIBEIRO COROSSACZ, 2010; 2012; 2014; 2015). L’un des aspects les plus saillants qui émerge de ces interviews, sont les récits sur l’accès sexuel au corps de l’empregada doméstica par le jeune homme blanc et de classe moyenne supérieure. Neste artigo, abordo a temática dos assédios sexuais contra as trabalhadoras domésticas, utilizando os dados de duas pesquisas conduzidas no Rio de Janeiro. Na primeira, realizada entre 2009 e 2012, entrevistei 21 homens da cidade do Rio de Janeiro, com idade entre 43 e 60 anos, os quais se autodefinem brancos e de classe média alta. Nessas entrevistas, enfrentei diferentes aspectos das experiências biográficas relativas à branquitude e à masculinidade (RIBEIRO COROSSACZ, 2010, 2014a, 2014b, 2015). Um dos aspectos mais salientes diz respeito aos relatos sobre o acesso sexual ao corpo da trabalhadora doméstica pelo jovem homem branco de classe média alta. Trata-se, portanto, de histórias que remontam à adolescência dos homens entrevistados.
The Growth Of White Oyster Mushroom Mycelium (Pleurotus ostreatus) (Jacq) (P. Kumm) From Liquid And Solid Inoculum
Authors: Nisfaun Safitriana  , Umrah  , Orryani Lambui  
Published: January 2020

The study about the growth of white oyster mushroom mycelium (Pleurotus ostreatus) (Jacq) (P. Kumm) from liquid and solid inoculum conducted on January until July 2018 in Biotechnology laboratory, Biology Department, Faculty of Math and Science, Tadulako University. This study was aimed to find out the mycelium growth of source of stem inoculum and hood in liquid and solid media. This study was designed by Complete Randomized Design (CRD) which consisted of four treatments and five replications. The treatment were M1 (source of stem inoculum in liquid medium), M2 (source of stem inoculum in solid medium), M3 (source of hood inoculum in liquid medium), and M4 (source of hood inoculum in solid medium). The parameters were (a) incubation time till mycelium fills medium, (b) CFU, and (c) the viability of inoculum on producing medium. The result showed that the faster incubation were M1 and M3 (for 2 days, higher CFU was M3 with an average number 8,2 x 10 10 CFU /ml. The faster viability of mycelium growth were M3 with an average growth of mycelium 6,97 cm/days.
Formulation of Inoculum a white oyster Mushroom (Pleurotus ostreatus) on powder
Authors: Khadijah  , Umrah  , Orryani Lambui  
Published: January 2020

The study about the formulation of inoculum a white oyster mushroom (Pleurotus ostreatus) on flour. was conducted at Biotechnology laboratory of Departement , Faculty of Mathematic and Natural Science, Tadulako University. This study were aimed to oyster mushroom on production. on and to abridge the cycle of oyster mushroom production process of white.peplication used Compeletely Randomized Design (CRD) consist of six treatments and tree by comparing between (sawduts,rice,bran, and comflour) P1(50% : 27% : 23% , P2 (50% : 30% : 20%), P3 (50% : 33% : 17%), P4 (50% : 36% : 14% ), P5 (50% : 39% : 11%), P6 (50% : 42% : 8%). There are four parameters used in this study (1) .The growth of white oyster mushroom inoculum (2) the incubation time. and, (3) coloni forming unit (CFU), (4) Viability test .The resulth showed that the best growth mycelium was 1,3cm/days with incubation period was 26 days, the highest total of CFU in P5 was 12,7x 108 CFU/ml and was in P3 was 3,3 x 108 CFU/ml .The inoculum viability test of production media in P5, was faster in incubation period is 18 days.