bluuebunny/crossref_metadata_2025_split huggingface dataset:
LOS EFECTOS DE LA CENSURA FRANQUISTA: LA JUERGA (1957), UNA NOVELA INÉDITA DE ÁNGEL MARÍA DE LERA (1912-1984)
Authors: Jorge de Sande María del Mar 
Published: December 2019

Ángel María de Lera (1912 – 1984), autor de éxito en las décadas del sesenta y setenta del pasado siglo, es en la actualidad un escritor apenas recordado y muy poco conocido. Y ello a pesar de ocupar un importante lugar en la Historia de la Literatura española gracias a Las últimas banderas (Premio Planeta 1967), una de las primeras novelas publicadas en España que trata sobre la Guerra Civil desde la perspectiva de un vencido. Muy poco conocidas son también las muchas dificultades que hubo de enfrentar para publicar algunas de sus obras a consecuencia de la censura.Con este artículo nos proponemos rescatar del olvido la novela La juerga [1957, 1961], sepultada en los archivos de la represión franquista durante casi sesenta años. Su análisis desde el punto de vista literario pondrá de manifiesto cómo el hecho de que esta novela quedara inédita constituye una grave mutilación en el conjunto de la obra de Lera; con el estudio de su expediente de censura esperamos arrojar luz sobre las posibles causas por las que a Lera le resultó imposible publicarla, al tiempo que confiamos en hacer una pequeña aportación a la reconstrucción del complejo entramado de la institución censoria. Kaum jemand erinnert sich heute noch an Ángel María de Lera (1912 – 1984), einen Erfolgsautor in den 60er und 70er Jahren des letzten Jahrhunderts, kaum jemand kennt ihn überhaupt. Und dennoch hat er aufgrund seines Romans Las últimas banderas (Premio Planeta 1967) einen bedeutenden Platz in der Geschichte der spanischen Literatur inne, war es doch immerhin einer der ersten in Spanien veröffentlichten Romane, in denen es um den Spanischen Bürgerkrieg aus dem Blickwinkel eines Besiegten ging. Wenig sind auch die vielen Schwierigkeiten bekannt, denen sich Lera infolge der damals herrschenden Zensur bei der Veröffentlichung einiger seiner Werke ausgesetzt sah. Mit diesem Artikel soll der Roman La Juerga [1957, 1961] vor dem Vergessen bewahrt werden. Fast 60 Jahre lang war er begraben in den Archiven, in denen die Zeugnisse der franquistischen Unterdrückung aufbewahrt werden. Die literarische Analyse von La Juerga zeigt klar und deutlich, dass, diesen Roman dem Publikum weiterhin vorzuenthalten, dem Gesamtwerk von Lera schweren Schaden zufügen würde. Der genaue Blick in die Unterlagen der Zensurbehörde wird Licht werfen auf die möglichen Gründe, die dazu geführt haben, dass dieser Roman nicht veröffentlicht werden konnte, und so sicherlich einen kleinen Beitrag dabei leisten, die komplexe Struktur der institutionalisierten Zensur zu rekonstruieren.
THE IMPACT OF VEGETARIAN DIETS AND BODY MASS INDEX ON HYPERTENSION
Authors: Mariha Tri , Wiarsih Wiwin 
Published: December 2019

A vegetarian diet is believed to prevent hypertension. This study aims to identify the impact of vegetarian diets, including fat, salt, potassium, and body mass index (BMI), on hypertension. Data was taken by systematic random sampling method from 173 vegetarians and analyzed using chi-square. The result showed that there is no significant association between the intake of fat, sodium, and potassium with hypertension in vegetarians (p> 0.05). However, there is a significant relationship between BMI with the incidence of hypertension (p= 0.025), where overweight res-pondents are 3.837 more likely to have hypertension (OR 3.837; 95% CI= 1,256–11,721). It implies that vegetarians tend to have a safe intake of fat, salt, and potassium, and therefore, this condition prevents hypertension. Thus, health promotion about the selection of sources of fat, regulation of salt, potassium intake, and weight management will be beneficial for vegetarians in preventing hypertension. Keywords: BMI, diet, hypertension, vegetarian Abstrak Dampak Diet Vegetarian dan Indeks Massa Tubuh terhadap Hipertensi. Diet vegetarian diyakini dapat mencegah hipertensi. Penelitian ini bertujuan untuk mengetahui dampak diet vegetarian, meliputi asupan lemak, garam, kalium, dan Indeks Massa Tubuh (IMT) terhadap hipertensi. Data diperoleh melalui metode systematic random sampling pada 173 vegetarian dan dianalisis menggunakan chi-square. Tidak ada hubungan yang signifikan antara asupan lemak, garam, dan kalium pada vegetarian dengan hipertensi (p> 0.05). Namun, terdapat hubungan yang signifikan antara IMT dengan kejadian hipertensi (p= 0.025), dimana responden dengan berat badan berlebih 3.837 kali berpeluang lebih besar untuk mengalami hipertensi (OR 3.37; 95% CI= 1.256–11.721). Hal ini menunjukkan bahwa vegetarian cenderung memiliki asupan lemak, garam, dan kalium yang aman sehingga kondisi ini dapat mencegah hipertensi. Dengan demikian, promosi kesehatan mengenai pemilihan sumber lemak, pengaturan asupan garam:kalium, dan manajemen berat badan akan sangat bermanfaat bagi vegetarian untuk mencegah hipertensi. Kata kunci: diet, hipertensi, IMT, vegetarian
On T1 T2-g-Open Sets in Bitopological Spaces
Authors: Vithyasangaran K. , Elango P. , Sathaananthan S. , Sriranganesan J. , Paramadevan P. 
Published: December 2019

In this paper, we introduced and studied a new kind of generalized open set called τ1τ2-g-open set in a bitopological space (X, τ1, τ2). The properties of this τ1τ2-g-open set are studied and compared with some of the corresponding generalized open sets in general topological spaces and bitopological spaces. We also dened the τ1τ2-g-continuous function and studied some its properties.
Electron Transport Mechanism of Mitochondrial Respiratory Megacomplex
I2III2IV2
Authors: Yang Maojun 
Published: December 2019

Abstract
Respiration is the center of energy metabolism in mammals, and mitochondrial respiratory chain complexes play a major role in energy conversion. According to the high‐resolution structures of individual complexes and the assembled supercomplex resolved recently, we can now try to elucidate the electron transfer and coupled proton pumping mechanism at molecular level. Together with previously accumulated biochemical data, although an overall agreement on the electron pathways was reached, some vital details are still controversial, including the ubiquinone reduction manner in complex I and ubiquinol binding position in CIII. Besides, recently our group reported the first medium‐resolution structure of megacomplex from cultured human cells, showing that two sets of complex I, III, IV and even II may function in a coordinated manner, making the electron pathway even more complex. In this article, we discuss electron transfer between individual complexes in respirasome, describe the megacomplex model, and compare two different electron pathways inside complex III.
Acid‐Triggered Charge‐Convertible Graphene‐Based All‐in‐One Nanocomplex for Enhanced Genetic Phototherapy of Triple‐Negative Breast Cancer
Authors: Wu Chunhui , Tian Yuan , Zhang Yingxue , Xu Jiming , Wang Yikun , Guan Xiaotian , Li Tingting , Yang Hong , Li Shun , Qin Xiang , Liu Yiyao 
Published: December 2019

AbstractHighly efficient and stimulus‐responsive nanomedicines for cancer treatment are currently receiving tremendous attention. In this study, an acid‐triggered charge‐reversible graphene‐based all‐in‐one nanocomplex is appropriately designed by surface modification with multilayer polymers and simultaneous co‐transportation of photosensitizer indocyanine green (ICG) and oligonucleotide inhibitor of miR‐21 (miR‐21i) to achieve highly efficient genetic phototherapy in a controlled manner. The nanocomplex (denoted as GPCP/miR‐21i/ICG) effectively protects miR‐21i from degradation and exhibits excellent photothermal/photochemical reactive oxygen species (ROS) generation as well as fluorescence imaging ability. The cargoes ICG and miR‐21i can significantly be released at acidic pH compared with normal physiological medium and escaped from endosomes/lysosomes due to the acid‐triggered charge reversal effect. Typically, the released miR‐21i downregulate the endogenous miR‐21 and result in the upregulation of the target proteins PTEN and Bax, thus increasing the phototherapeutic efficiency of ICG. High in vivo anticancer efficiency against the MDA‐MB‐231 triple‐negative breast cancer (TNBC) model is obtained due to the combination of genetic regulation of miR‐21i and the photokilling effect of ICG. This work highlights the great potential of this smart nanocomplex as an attractive modality of gene‐photo combined treatment of cancer, especially for intractable TNBC.
Developments of Diketopyrrolopyrrole‐Dye‐Based Organic Semiconductors for a Wide Range of Applications in Electronics
Authors: Liu Qian , Bottle Steven E. , Sonar Prashant 
Published: December 2019

AbstractIn recent times, fused aromatic diketopyrrolopyrrole (DPP)‐based functional semiconductors have attracted considerable attention in the developing field of organic electronics. Over the past few years, DPP‐based semiconductors have demonstrated remarkable improvements in the performance of both organic field‐effect transistor (OFET) and organic photovoltaic (OPV) devices due to the favorable features of the DPP unit, such as excellent planarity and better electron‐withdrawing ability. Driven by this success, DPP‐based materials are now being exploited in various other electronic devices including complementary circuits, memory devices, chemical sensors, photodetectors, perovskite solar cells, organic light‐emitting diodes, and more. Recent developments in the use of DPP‐based materials for a wide range of electronic devices are summarized, focusing on OFET, OPV, and newly developed devices with a discussion of device performance in terms of molecular engineering. Useful guidance for the design of future DPP‐based materials and the exploration of more advanced applications is provided.
High‐Efficiency White Organic Light‐Emitting Diodes Based on All Nondoped Thermally Activated Delayed Fluorescence Emitters
Authors: Zhang Guang‐Hui , Xie Feng‐Ming , Wu Kailong , Li Yan‐Qing , Xie Guohua , Zou Shi‐Jie , Shen Yang , Zhao Xin , Yang Chuluo , Tang Jian‐Xin 
Published: December 2019

AbstractWhile phosphorescent white organic light‐emitting diodes (WOLEDs) have attracted great attention due to their high efficiencies, the complex device structure (e.g., host–dopant systems) and the adoption of novel metals (e.g., Ir or Pt) inevitably increase the fabrication complication and manufacturing cost. Herein, a simple and cost‐effective structure based on all thermally activated delayed fluorescence (TADF) emitters is proposed to achieve high‐performance WOLEDs. The key feature of the WOLED structure is to insert an orange‐red TADF ultrathin layer within the nondoped blue TADF emitter, which can significantly reduce the energetic loss and therefore the operating voltage during electron–photon conversion process. After optimizing the energy transfer and exciton formation region between two color‐complementary TADF emitters, the all‐fluorescence WOLEDs exhibit an extremely high external quantum efficiency of 24.2% with a turn‐on voltage of 2.5 V and a color rendering index of >80. It is anticipated that the results will pave the way to the realization of high‐efficiency and low‐cost WOLEDs that can outperform the typical phosphorescent devices.
Engineering the Tenogenic Niche In Vitro with Microenvironmental Tools
Authors: Ryan Christina N. M. , Zeugolis Dimitrios I. 
Published: December 2019

AbstractTendon injuries affect millions of people worldwide annually. Considering that traditional approaches (e.g., surgery, exercise, steroid injections) have failed to reinstate tendon function following injury, recent efforts have been directed toward the development of cell‐based tendon repair and regeneration therapies. However, tenocytes readily lose their phenotype in culture and implantation of naïve stem cells is often associated with ectopic bone formation. To this end, there has been a surge in efforts to engineer the optimal tenogenic niche in vitro that will either maintain the phenotype of tenocytes or direct other cell types toward tenogenic lineage. Mono‐domain biochemical (e.g., media supplements, substrate coatings, oxygen tension), biological (e.g., growth factors, co‐culture systems), or biophysical (topography, rigidity, mechanical stimulation, macromolecular crowding) cues that replicate the native tendon milieu have shown some level of success, but they have failed to provide a functional therapy. Considering the complexity of the native tissue microenvironment together with recent advances in chemistry, biology, and engineering, it is anticipated that in the years to come multifactorial approaches are likely to yield a functional cell‐based therapy for tendon repair and regeneration.
Suppression of Concentration Quenching in Ortho‐Substituted Thermally Activated Delayed Fluorescence Emitters
Authors: Abroshan Hadi , Cho Eunkyung , Coropceanu Veaceslav , Brédas Jean‐Luc 
Published: December 2019

AbstractThermally activated delayed fluorescence (TADF) emitters are typically embedded at low concentrations in a host matrix to suppress emission quenching. However, recent studies indicate that TADF compounds such as the oBFCzTrz emitter (5‐(2‐(4,6‐diphenyl‐1,3,5‐triazin‐2‐yl)phenyl)‐5H‐benzofuro[3,2‐c]carbazole) display insignificant concentration quenching dependence. To understand the origin of this beneficial behavior, the morphology, dynamics, electronic properties, and charge transport and energy transfer in a neat film of the oBFCzTrz emitter are characterized via molecular dynamic simulations combined with density functional theory calculations. The emissive layer shows glassy behavior at room temperature with the twisted configurations of the emitter molecules allowing for intramolecular donor–acceptor interactions, but disfavoring intermolecular π–π stacking, which suppresses the formation of intermolecular aggregate states. As a result, the electronic structure and luminescence of oBFCzTrz are not significantly altered by intermolecular interactions. The calculated diffusion lengths of the singlet and triplet excitons are small enough that there occurs no substantial concentration quenching effect. Overall, the design of new TADF emitters with structural motifs similar to those of oBFCzTrz offers potential to develop efficient organic light‐emitting diode devices in which the emissive layers are entirely composed of TADF molecules without the need for a host component.
Biosynthesis and chemical characterization of polydopamine‐capped silver nanoparticles for the treatment of acute myeloid leukemia in comparison to doxorubicin in a leukemic mouse model
Authors: Hemmati Saba , Joshani Zeinab , Zangeneh Akram , Zangeneh Mohammad Mahdi 
Published: December 2019

The recent study reveals the cytotoxicity, antioxidant, and anti‐acute myeloid leukemia properties of polydopamine (PDA)‐capped silver nanoparticles (AgNPs) compared to doxorubicin in a leukemic mouse model. The synthesized AgNPs were characterized using different techniques including ultraviolet–visible spectroscopy (UV–Vis.), Fourier‐transform infrared spectroscopy (FT‐IR) spectroscopy, X‐ray diffraction (XRD), energy Dispersive X‐ray Spectrometry (EDS), field emission‐scanning electron microscopy (FE‐SEM), and transmission electron microscopy (TEM). FE‐SEM and TEM images revealed a uniform spherical morphology and average diameters of 15–25 nm for the nanoparticles. Also, in XRD analysis, ~20 nm was measured for the crystal size of nanoparticles. The results of the biological experiments were fed into SPSS‐22 software and analyzed by one‐way ANOVA. In the biological in vitro part of this study, AgNPs similar to doxorubicin had low cell viability dose‐dependently against Human HL‐60/vcr, 32D‐FLT3‐ITD, and Murine C1498 cell lines without any cytotoxicity on HUVEC cell line. In this study, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) test revealed similar antioxidant potentials for doxorubicin and AgNPs. In the biological in vivo part of this study, induction of acute myeloid leukemia was done by 7,12‐Dimethylbenz[a]anthracene (DMBA) in 75 mice. Then, the animals were randomly divided into six subgroups, including control, untreated, doxorubicin, AgNPs, PDA, and AgNO3. AgNPs similar to doxorubicin, significantly (p ≤ 0.05) reduced the pro‐inflammatory cytokines, and the total white blood cell (WBC), blast, monocyte, neutrophil, eosinophil, and basophil counts and enhanced the anti‐inflammatory cytokines and the platelet, lymphocyte, and red blood cell (RBC) parameters as compared to the untreated mice. By quantitative real‐time polymerase chain reaction (PCR), sphingosine‐1‐phosphate receptor‐1 (S1PR1) and sphingosine‐1‐phosphate receptor‐5 (S1PR5) mRNA expression in lymphocytes were significantly (p ≤ 0.05) raised by treating the leukemic mice with the AgNPs and doxorubicin. Above results confirm the therapeutic effects of AgNPs on acute myeloid leukemia in the leukemic mice. Further clinical trials are necessary for confirmation these remedial properties of AgNPs in human.
Assessment of compatibilization role of nanoclay in immiscible polystyrene/ethylene–octene copolymer blends via wide‐angle X‐ray scattering, microstructure, rheological analyses, and mechanical properties
Authors: Kiani Fatemeh , Entezam Mehdi , Khonakdar Hossein Ali , Jafari Seyed Hassan , Callsen Christoph , Altstädt Volker 
Published: December 2019

ABSTRACTPolystyrene (PS)/ethylene–octene copolymer (EOC) blends with 80/20 wt % composition containing different amounts (0, 1.0, 2.5, 5.0 and 7.5 wt %) of an organically modified nanoclay were prepared by one‐step melt‐mixing method. Also, the EOC‐rich blends with 80 wt % EOC content loaded with 0 and 5.0 wt % of the nanoclay were prepared under the similar processing conditions. Presence of both PS and EOC chains in between clay layers localized at the interface of the blends could be deduced by X‐ray diffraction analysis, which suggested formation possibility of PS‐EOC physical structures at the blend interface. Transmission electron microscopy results confirmed that clay nanoparticles were mainly localized at the interface of the blends and also partly in the PS and EOC components of the systems. The localization of the nanoclay was also described by the linear viscoelastic melt rheological studies. It is also revealed that nanoclay had stronger interactions with PS than EOC. This is reflected in the higher tensile properties in the PS‐rich system. The analysis of morphology of the developed systems by emulsification curve revealed that the optimum amount of nanoclay to modify PS‐rich blend is 2.5 wt %. At this clay loading, the blend exhibited the highest impact resistance. According to the overall results, suitability of nanoclay was confirmed for compatibilization of the PS/EOC blends. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48748.
Solid‐state shear milling method to prepare PA12/boron nitride thermal conductive composite powders and their selective laser sintering 3D‐printing
Authors: Yang Lu , Wang Lequan , Chen Yinghong 
Published: December 2019

ABSTRACTThe selective laser sintering (SLS) is one of the most important 3D‐printing technologies. However, the challenges in SLS could be in the limited high material cost and single material performance. Development of high‐performance and multifunctional copowders suitable for SLS is of great importance. Here, polyamide 12 (PA12)/boron nitride (BN) thermal conductive copowders suitable for SLS were successfully prepared through solid state shear milling (S3M) technology in combination with cryogenic pulverization technology. The particle size, morphology, grafting reaction between PA12 and BN, rheology behavior, and coalescence behavior of the obtained PA12/BN copowders were carefully investigated. The optimal amount of silica flow additive (0.5 wt %) was determined to achieve the good powder flowability. Under the optimum 3D‐printing conditions, the fabrication of parts with high BN loading could be achieved. When BN content was at 40 wt %, the flexural strength could reach 10.6 MPa and the thermal conductivity could reach 0.55 W/m·k, 77% higher than that of pure PA12. After treated with phenolic epoxy resin, the tensile strength and flexural strength of the printed parts with 40 wt % BN loading could reach 14.2 and 25.6 MPa, which were 130 and 115% higher than those of the untreated 3D‐printed parts, respectively. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48766.
Organocatalyzed Synthesis of Functionalized Quinolines
Authors: Li Lian‐Hua , Niu Zhi‐Jie , Liang Yong‐Min 
Published: December 2019

AbstractAs one of the most widely investigated compound skeleton, quinolines possess important medicinal and biological activities. As such, a great number of literatures, including reviews, have reported various methodologies to construct quinolines. Recently, organocatalyzed reactions have attracted the attention of organic chemists due to its being “green” because the reactions avoid the use of toxic metals. In this review, various distinctive contributions are surveyed with specific emphasis on organocatalyzed reactions for quinoline core constructions.
Identification of Pediatric Autism Spectrum Disorder Cases Using Health Administrative Data
Authors: Bickford Celeste D. , Oberlander Tim F. , Lanphear Nancy E. , Weikum Whitney M. , Janssen Patricia A. , Ouellette‐Kuntz Helene , Hanley Gillian E. 
Published: December 2019

Administrative data are frequently used to identify Autism Spectrum Disorder (ASD) cases in epidemiological studies. However, validation studies on this mode of case ascertainment have lacked access to high‐quality clinical diagnostic data and have not followed published reporting guidelines. We report on the diagnostic accuracy of using readily available health administrative data for pediatric ASD case ascertainment. The validation cohort included almost all the ASD‐positive children born in British Columbia, Canada from April 1, 2000 to December 31, 2009 and consisted of 8,670 children in total. 4,079 ASD‐positive and 2,787 ASD‐negative children were identified using Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview‐Revised (ADI‐R) assessments done through the British Columbia Autism Assessment Network (BCAAN). An additional 1,804 ADOS/ADI‐R assessed ASD‐positive children were identified using Ministry of Education records. This prospectively collected clinical data (the diagnostic gold standard) was then linked to each child's physician billing and hospital discharge data. The diagnostic accuracy of 11 algorithms that used the administrative data to assign ASD case status was assessed. For all algorithms, high positive predictive values (PPVs) were observed alongside low values for other measures of diagnostic accuracy illustrating that PPVs alone are not an adequate measure of diagnostic accuracy. We show that British Columbia's health administrative data cannot reliably be used to discriminate between children with ASD and children with other developmental disorders. Utilizing these data may result in misclassification bias. Methodologically sound, region‐specific validation studies are needed to support the use of administrative data for ASD case ascertainment. Autism Res 2020, 13: 456–463. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryHealth administrative data are frequently used to identify Autism Spectrum Disorder (ASD) cases for research purposes. However, previous validation studies on this sort of case identification have lacked access to high‐quality clinical diagnostic data and have not followed published reporting guidelines. We show that British Columbia's health administrative data cannot reliably be used to discriminate between children with ASD and children with other developmental disorders.