bluuebunny/crossref_metadata_2025_split huggingface dataset:
De dagvaardingsprocedure in civiele zaken bij de rechtbank in eerste aanleg in Duitsland vergeleken met de Nederlandse procedure na KEI-wetgeving en Spoedwet KEI
Authors: Mehring Eckhard 
Published: August 2020

De dagvaardingsprocedure in civiele zaken bij de rechtbank in eerste aanleg in Duitsland vergeleken met de Nederlandse procedure na KEI-wetgeving en Spoedwet KEI
Het Burgerlijke Procesrecht heeft zowel in Duitsland alsook in Nederland in de afgelopen decennia belangrijke wijzigingen ondergaan. Op een aantal punten kan een benadering worden vastgesteld. Maar er blijven ook kenmerkende verschillen. Deze bijdrage levert een korte schets van de Duitse civiele procedure in eerste aanleg en geeft daarbij ook aan waar met de Nederlandse procedure overeenkomsten zijn en waar nog steeds verschillen bestaan.
De Tijdelijke Experimentenwet rechtspleging nader beschouwd
Authors: Hoogervorst Elselique , Jahan Parisa 
Published: August 2020

De Tijdelijke Experimentenwet rechtspleging nader beschouwd
De Tijdelijke Experimentenwet rechtspleging is geïntroduceerd ter bevordering van een eenvoudige, snelle, effectieve en de-escalerende geschilbeslechting. De wet maakt een scala aan afwijkingen van het reguliere procesrecht mogelijk. Een experimentele procedure wordt opgenomen in een amvb en heeft een tijdelijk karakter van in beginsel maximaal drie jaar. De wetgever heeft een aantal concrete experimenten voor ogen waaronder een experiment met een toegevoegd deskundig lid in een kamer van een rechtbank of hof en een experiment met een nabijheidsrechter. In deze bijdrage bespreken wij de voorgestelde regeling op hoofdlijnen en plaatsen wij een aantal kanttekeningen bij de wet en de voorgestelde experimenten.
Madīḥ al-karāhiya de Ḫālid Ḫalīfa
Authors: Censi Martina 
Published: August 2020

Dans Madīḥ al-karāhiya (L’éloge de la haine), roman publié en 2006, l’écrivain syrien Ḫālid Ḫalīfa se consacre à la représentation littéraire du martyre. Dans cette œuvre, la relation entre corps, violence et identité devient un moyen pour représenter et contester toute forme de pouvoir répressif – politique et religieux – ayant ravagé la Syrie pendant les années 1980. La protagoniste est une adolescente – issue d’une famille musulmane d’Alep – bouleversée par les changements de son corps. Sa volonté d’échapper à ses désirs sexuels et à la manifestation de plus en plus visible de sa féminité entraîne son rapprochement d’un groupe d’extrémistes musulmans qui pratiquent la lutte armée. En portant son attention sur l’individu féminin, Ḫālid Ḫalīfa s’interroge sur le rôle de la violence liée à la religion dans les processus de subjectivation des individus. Le corps féminin adolescent devient le symbole de la différence « hors-norme » de l’individu qui n’arrive pas à trouver sa place dans la société. Le martyre est le moyen pour la protagoniste de définir son identité individuelle et de s’approprier son corps en l’imposant sur l’espace public et sur la collectivité.
Exploring stakeholders' experience of implementing quality enhancement in selected South African universities
Authors: Sondlo Mercy , Herman Chaya 
Published: August 2020

Abstract
In 2014, the Council on Higher Education (CHE) in South Africa introduced the Quality Enhancement Project (QEP) with a view to address the failure of traditional audits to improve student success and throughput. Through the lens of Bowe, Ball and Gold (1992)’ policy implementation theory, this article explores stakeholder experiences of the implementation of the intervention at four universities in South Africa. A qualitative, multiple case study research design was applied and purposive sampling of stakeholders was conducted using in-depth individual, focus group interviews and document analysis.
The findings revealed that whilst there were both positive and negative outcomes in Bowe, Ball and Gold (1992)’ three contexts: the context of influence had a potential to influence change, the context of policy text production and the context of practice did not bring about the envisioned change. This suggests complexities of policy implementation influenced by different contexts of and approaches to QEP implementation. Critical findings suggest that the QEP was unsustainable due to a project mentality among stakeholders, the effects of the unstable higher education environment, lack of a change theory, policy borrowing, insufficient funds and lack of resources.
Key words: quality enhancement, project mentality, Higher education South Africa, policy implementation.
In vivo anti‐V‐ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses
Authors: Kulshrestha Arpita , Katara Gajendra K. , Ibrahim Safaa A. , Riehl Valerie E. , Schneiderman Sylvia , Bilal Mahmood , Young Alexandria N. , Levine Shayna , Fleetwood Sara , Dolan James , Gilman‐Sachs Alice , Beaman Kenneth D. 
Published: August 2020

Tumor acidity is the key metabolic feature promoting cancer progression and is modulated by pH regulators on a cancer cell's surface that pump out excess protons/lactic acid for cancer cell survival. Neutralizing tumor acidity improves the therapeutic efficacy of current treatments including immunotherapies. Vacuolar‐ATPase (V‐ATPase) proton pumps encompass unique plasma membrane‐associated subunit isoforms, making this molecule an important target for anticancer therapy. Here, we examined the in vivo therapeutic efficacy of an antibody (a2v‐mAB) targeting specific V‐ATPase‐‘V0a2’ surface isoform in controlling ovarian tumor growth. In vitro a2v‐mAb treatment inhibited the proton pump activity in ovarian cancer (OVCA) cells. In vivo intraperitoneal a2v‐mAb treatment drastically delayed ovarian tumor growth with no measurable in vivo toxicity in a transplant tumor model. To explore the possible mechanism causing delayed tumor growth, histochemical analysis of the a2v‐mAb‐treated tumor tissues displayed high immune cell infiltration (M1‐macrophages, neutrophils, CD103+ cells, and NK cells) and an enhanced antitumor response (iNOS, IFN‐y, IL‐1α) compared to control. There was marked decrease in CA‐125‐positive cancer cells and an enhanced active caspase‐3 expression in a2v‐mAb‐treated tumors. RNA‐seq analysis of a2v‐mAb tumor tissues further revealed upregulation of apoptosis‐related and toll‐like receptor pathway‐related genes. Indirect coculture of a2v‐mAb‐treated OVCA cells with human PBMCs in an unbuffered medium led to an enhanced gene expression of antitumor molecules IFN‐y, IL‐17, and IL‐12‐A in PBMCs, further validating the in vivo antitumor responses. In conclusion, V‐ATPase inhibition using a monoclonal antibody directed against the V0a2 isoform increases antitumor immune responses and could therefore constitute an effective treatment strategy in OVCA.
Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1‐CX3CR1 dependent manner and induce tumour cell apoptosis
Authors: Miao Shuo , Lu Meng , Liu Yue , Shu Dan , Zhu Ying , Song Wei , Ma Yuanyuan , Ma Rong , Zhang Bixiang , Fang Chao , Ming Zhang‐Yin 
Published: August 2020

The mechanisms and biological functions of migrating platelets in cancer remain largely unknown. Here, we analyzed platelet infiltration in hepatocellular carcinoma. We detected platelet extravasation in both mouse and human HCC tissues. CX3CL1 directly induced platelet migration, and hypoxia enhanced platelet migration by upregulating CX3CL1 expression. Knocking down CX3CL1 in HCC cells reduced platelet migration in vitro, as well as infiltration of HCC tissue in an orthotopic HCC mouse model. Components of the CX3CR1/Syk/PI3K pathway were essential for CX3CL1‐induced platelet migration. Migrating platelets induced HCC cell apoptosis in vitro, as indicated by a reduced mitochondrial membrane potential and an increased percentage of apoptotic cells. In the orthotopic tumor implantation model, decreased platelet infiltration was associated with accelerated tumor growth. Taken together, our findings indicate that HCC cell‐derived CX3CL1 contributes to tumor infiltration by platelets, which in turn promotes apoptosis of HCC cells.
Evaluation of the RUBY modular QA phantom for planar and non‐coplanar VMAT and stereotactic radiations
Authors: Poppinga Daniela , Kretschmer Jana , Brodbek Leonie , Meyners Jutta , Poppe Bjoern , Looe Hui Khee 
Published: August 2020

AbstractPurposeThis study evaluates the clinical use of the RUBY modular QA phantom for linac QA to validate the integrity of IGRT workflows including the congruence of machine isocenter, imaging isocenter, and room lasers. The results have been benchmarked against those obtained with widely used systems. Additionally, the RUBY phantom has been implemented to perform system QA (End‐to‐End testing) from imaging to radiation for IGRT‐based VMAT and stereotactic radiations at an Elekta Synergy linac.Material and MethodsThe daily check of IGRT workflow was performed using the RUBY phantom, the Penta‐Guide, and the STEEV phantom. Furthermore, Winston–Lutz tests was carried out with the RUBY phantom and a ball‐bearing phantom to determine the offsets and the diameters of the isospheres of gantry, collimator, and couch rotations, with respect to the room lasers and kV‐imaging isocenter. System QA was performed with the RUBY phantom and STEEV phantom for eight VMAT treatment plans. Additionally, the visibility of the embedded objects within these phantoms in the images and the results of CT and MR image fusions were evaluated.ResultsAll systems used for daily QA of IGRT workflows show comparable results. Calculated shifts based on CBCT imaging agree within 1 mm to the expected values. The results of the Winston–Lutz test based on kV imaging (2D planar and CBCT) or room lasers are consistent regardless of the system tested. The point dose values in the RUBY phantom agree to the expected values calculated using algorithms in Masterplan and Monte Carlo engine in Monaco within 3% of the clinical acceptance criteria.ConclusionAll the systems evaluated in this study yielded comparable results in terms of linac QA and system QA procedures. A system QA protocol has been derived using the RUBY phantom to check the IGRT‐based VMAT and stereotactic radiations workflow at an Elekta Synergy linac.
Intentions to report concussion symptoms in nonprofessional athletes: A fuzzy‐trace theory approach
Authors: Garavito David M. N. , Reyna Valerie F. , DeTello Joseph E. , Landow Bailey R. , Tarpinian Lindsey M. 
Published: August 2020

SummaryReducing concussion risks in athletes depends on self‐reporting. Often, athletes decide whether to report concussions or continue playing and risk serious health consequences. Fuzzy‐trace theory (FTT) predicts that reliance on gisty, categorical representations of risky decisions, not amounts of risk/reward, encourages risk avoidance and application of bottom‐line values, or gist principles, thus promoting healthy decisions. Applying FTT, we test whether intentions to report are predicted by gist‐based thinking about risks and values. High school and college students (N= 1,366) were assessed for concussion knowledge, social pressures to not report (by coaches/parents/teammates), categorical gist‐based thinking, endorsement of gist principles expressing values, and intentions to report. As expected, the older group scored higher on gist measures. For young adults, categorical thinking, and gist principles predicted intentions, controlling for sex, knowledge, and social pressures. For adolescents, categorical thinking again predicted intentions. For both age groups, adding FTT's predictors accounted for significantly more variance than baseline models.
Adults also have difficulty recalling one instance of a repeated event
Authors: Deck Sarah L. , Paterson Helen M. 
Published: August 2020

SummarySome forms of abuse, such as domestic violence, tend to occur repeatedly. Although memory for repeated events has received considerable empirical attention, most of this research has used a child sample. Experiments that have examined adult repeated‐event memory tend to use vastly different methodological paradigms to that used for children. To investigate whether the same pattern of findings emerge with young adults, we adapted the methodological paradigm used in child repeated‐event experiments. In this experiment, 41 undergraduate students experienced one, or multiple similar events. All participants were then interviewed about the same event. Participants who had experienced a single‐event were more likely to report correct details than those who had experienced a repeated event. Repeated‐event participants were more likely to report general details. These results have implications for the methodological paradigm which is used to examine adult memory for a recurring event.
Persuasiveness and sensitivity to witnessing conditions depend on how testimony is presented
Authors: Hicks J. Marie , Clark Steven E. 
Published: August 2020

SummaryThe present experiment examined the persuasiveness (measured primarily by proportions of guilty verdicts) of the testimony of a single eyewitness as a function of witnessing conditions and method of presenting the testimony–via a Video or Audio recording or a written Transcript or Summary. Proportions of guilty verdicts showed little variation across presentation methods when witnessing conditions were relatively good, but were higher for Video and Audio presentations than for Transcript and Summary presentations when witnessing conditions were relatively poor. These results combined to show a decrease in sensitivity to witnessing conditions for Video and Audio presentations relative to Transcript and Summary presentations. These results were accounted for by a simple weighted cues model.
Cervical Cancer Screening in Women With Systemic Lupus Erythematosus
Authors: Bruera Sebastian , Lei Xiudong , Zogala Richard , Pundole Xerxes , Zhao Hui , Giordano Sharon H. , Hwang Jessica P. , Rauh‐Hain J. Alejandro , Suarez‐Almazor Maria E. 
Published: August 2020

ObjectiveTo determine rates of cervical cancer screening and associated abnormal results in women with systemic lupus erythematosus (SLE).MethodsWe identified women with an initial diagnosis of SLE in the MarketScan Commercial Claims and Encounters Database from 2001 to 2014. Cervical cancer screening rates and associated diagnostic claims within 3 years of the initial claim were determined. Multivariable logistic regression was performed to evaluate the association of screening with lupus treatment. A matched logistic regression analysis was conducted to compare screening rates to those in age‐matched women without connective tissue disease.ResultsWe included 4,316 women with SLE. Screening rates were higher in women with SLE than in general controls (73.4% versus 58.5%; P < 0.001). Factors associated with decreased screening included recent time (odds ratio [OR] 0.70 [95% confidence interval (95% CI)] 0.55–0.89) (2012–2014 compared to 2001–2005), age ≥61 years (OR 0.27 [95% CI 0.18–0.39]), comorbidity score ≥2 (OR 0.71 [95% CI 0.6–0.83]), corticosteroid use (OR 0.77 [95% CI 0.61–0.97]), and use of immunosuppressants (OR 0.80 [95% CI 0.69–0.94]). Abnormal pathology result claims were more common in women with SLE than in general controls (12.3% versus 9.8%; P < 0.001).ConclusionThough with higher rates than the general cohort, over 25% of the patients with SLE were not screened, and screening rates seem to be decreasing over time. Patients with SLE are at higher risk of abnormal cervical screening test results than controls, supporting the need for regular screening.
Determinants of Discordance Between Criteria for Inactive Disease and Low Disease Activity in Juvenile Idiopathic Arthritis
Authors: Giancane Gabriella , Campone Chiara , Gicchino Maria Francesca , Alongi Alessandra , Bava Cecilia , Rosina Silvia , Boyko Yaryna , Martin Neil , El Miedany Yasser , Harjacek Miroslav , Hashad Soad , Ioseliani Maka , Burgos‐Vargas Ruben , Joos Rik , Scott Christiaan , Manel Mejbri , Ayala Zoilo Morel , Ekelund Maria , Al‐Abrawi Safiya , Aiche Maya‐Feriel , Norambuena Ximena , Melo‐Gomes Jose Antonio , Ruperto Nicolino , Consolaro Alessandro , Ravelli Angelo ,   for the Paediatric Rheumatology International Trials Organisation
Published: August 2020

ObjectiveTo assess concordance among criteria for inactive disease (ID) and low disease activity (LDA) in juvenile idiopathic arthritis (JIA) and to seek factors driving discordance.MethodsThe frequency of fulfillment of existing criteria was evaluated in information on 10,186 patients extracted from 3 cross‐sectional data sets. Patients were divided up according to the functional phenotypes of oligoarthritis and polyarthritis. Concordance between criteria was examined using weighted Venn diagrams. The role of each individual component in explaining discordance between criteria was assessed by calculating the absolute number and percentage of instances in which the component was responsible for discrepancy between definitions.ResultsCriteria for ID were met by 28.6–41.1% of patients with oligoarthritis and by 24.0–33.4% of patients with polyarthritis. Criteria for LDA were met by 44.8–62.4% of patients with oligoarthritis and by 44.6–50.4% of patients with polyarthritis. There was a 57.9–62.3% overlap between criteria for ID and a 67.9–85% overlap between criteria for LDA. Parent and physician global assessments and acute‐phase reactants were responsible for the majority of instances of discordance among criteria for ID (8.7–15.5%, 10.0–12.3%, and 10.8–17.3%, respectively).ConclusionWe found fair concordance between criteria for ID and LDA in JIA, with the main drivers of discordance for ID being physician and parent global assessments and acute‐phase reactants. This observation highlights the need for further studies aimed to evaluate the impact of subjective physician and parent perception of disease remission and of laboratory measures of inflammatory activity on the definition of ID.
Do Obesity and Overweight Influence Disease Activity Measures in Axial Spondyloarthritis? A Systematic Review and Meta‐Analysis
Authors: Ortolan Augusta , Lorenzin Mariagrazia , Felicetti Mara , Ramonda Roberta 
Published: August 2020

ObjectiveThe aim of our systematic review and meta‐analysis was to investigate whether overweight/obesity are associated with higher disease activity measures in patients with axial spondyloarthritis (SpA).MethodsMEDLINE, PubMed, and Web of Science were searched using key terms corresponding to population (axial SpA patients), exposure (overweight/obesity), and outcome (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] and Ankylosing Spondylitis Disease Activity Score [ASDAS]). Predefined inclusion criteria were adult patients with axial SpA, exposure classified according to body mass index (BMI), BASDAI/ASDAS reported for each BMI group, and observational studies. The Newcastle‐Ottawa Scale for cohort, cross‐sectional, and case–control studies was used for quality check. Random‐effects meta‐analysis was used to pool results, which were expressed as the mean difference (MD) in BASDAI and ASDAS between BMI groups, with 95% confidence intervals (95% CIs).ResultsA total of 10 articles were included in the meta‐analysis. The MD in BASDAI between normal BMI and overweight/obese patients was –0.38 (95% CI –0.56, –0.21; P < 0.0001); the MD in ASDAS between the same groups was –0.19 (95% CI –0.29, –0.09; P < 0.0001). The MD in BASDAI between normal BMI and overweight patients was –0.09 (95% CI –0.33, 0.15; P = 0.45), and the MD between normal BMI and obese patients was –0.78 (95% CI –1.07, –0.48; P < 0.0001). For ASDAS, the MD between normal BMI and overweight patients was –0.02 (95% CI –0.19, 0.15; P = 0.79), and the MD between normal BMI and obese patients was –0.42 (95% CI –0.60, –0.23; P < 0.0001).ConclusionOverweight and obese patients with axial SpA tend to present higher disease activity scores compared to patients with a normal BMI. This difference seems to be clinically meaningful only for the comparison between obese patients and patients with normal BMI, and more for BASDAI than ASDAS.
Down Syndrome–Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes
Authors: Jones Jordan T. , Smith Chelsey , Becker Mara L. , Lovell Daniel ,   for the CARRA Registry Investigators
Published: August 2020

ObjectiveDown syndrome–associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize clinical manifestations and therapeutic preferences in DA compared to JIA, using the new Childhood Arthritis and Rheumatology Research Alliance (nCARRA) registry.MethodsIn a case–control study, between July 2015 and March 2019, patients with a diagnosis of JIA and Down syndrome (DS) were identified and matched by age, sex, and JIA subtype to patients who have JIA without DS. Collected data included demographic characteristics, disease characteristics, laboratory results, treatment exposure, and outcome measures.ResultsA total of 36 children with DA and 165 with JIA were identified. Most patients presented with polyarticular rheumatoid factor–negative disease. At entry into the nCARRA registry, there were minimal differences between the groups, and at the last visit there were significant differences (P < 0.05) for multiple outcome measures. Patients with DA and those with JIA had similar therapeutic exposure to disease‐modifying antirheumatic drugs (DMARDs) and biologics, but those with DA had more DMARD‐related adverse events (93% versus 25%) and biologic therapy ineffectiveness (60% versus 17%).ConclusionThere was little difference between patients with DA and those with JIA at baseline, and similar therapy was implemented for those in the nCARRA registry; however, at the last visit, the patients with DA had greater disease burden. Additionally, there were more DMARD‐related adverse events and biologic ineffectiveness for those patients with DA. More research is needed to determine differences in pathophysiology and optimal therapeutic approaches.