bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaborative concept mapping with reciprocal kit-build: a practical use in linear algebra course
Authors: Sadita Lia , Hirashima Tsukasa , Hayashi Yusuke , Wunnasri Warunya , Pailai Jaruwat , Junus Kasiyah , Santoso Harry Budi 
Published: July 2020

AbstractThe design of interactions among peers plays a key role in collaborative learning. Various strategies have been applied to assist learners in collaborating and creating a continuous effort to construct and maintain shared knowledge, such as utilizing a concept map as a representational tool during discourse. Some previous studies have revealed its positive effect on both the learning achievements and the attitudes of the students. A strategy for improving the quality of explanation of the students during collaborative concept mapping is to enable them to externalize their thinking in their private spaces beforehand. However, students may face difficulties when they need to integrate their individual propositions with the group concept map. This study employs the reciprocal kit-build (RKB) approach to help students externalize their ideas, understand and clarify their partners’ perspectives, integrating with their comprehension, hoping they can construct a high-quality collaborative product. The study is conducted in a linear algebra class in an Indonesian university. The effect of the RKB as learning activities on the group outcomes is evaluated. How students change their propositions, from the individual to the collaborative phase, following the visualization of the difference map provided by the RKB system is also presented. Perceptions of the students during these activities are examined to measure the effectiveness of the approach from the viewpoints of the participants. The findings convey that the RKB is promising for learning in a collaborative context despite some limitations in the practical classroom experimental settings.
DICOM segmentation and STL creation for 3D printing: a process and software package comparison for osseous anatomy
Authors: Kamio Takashi , Suzuki Madoka , Asaumi Rieko , Kawai Taisuke 
Published: July 2020

Abstract
Background
Extracting and three-dimensional (3D) printing an organ in a region of interest in DICOM images typically calls for segmentation as a first step in support of 3D printing. The DICOM images are not exported to STL data immediately, but segmentation masks are exported to STL models. After primary and secondary processing, including noise removal and hole correction, the STL data can be 3D printed. The quality of the 3D model is directly related to the quality of the STL data. This study focuses and reports on the DICOM to STL segmentation performance for nine software packages.

Methods
Multidetector row CT scanning was performed on a dry human mandible with two 10-mm-diameter bearing balls as a phantom. The DICOM image file was then segmented and exported to an STL file using nine different commercial/open-source software packages. Once the STL models were created, the data (file) properties and the size and volume of each file were measured, and differences across the software packages were noted. Additionally, to evaluate differences between the shapes of the STL models by software package, each pair of STL models was superimposed, with the observed differences between their shapes characterized as the shape error.
Results: The data (file) size of the STL file and the number of triangles that constitute each STL model were different across all software packages, but no statistically significant differences were found across software packages. The created ball STL model expanded in the X-, Y-, and Z-axis directions, with the length in the Z-axis direction (body axis direction) being slightly longer than that in the other directions. The mean shape error between software packages of the mandibular STL model was 0.11 mm, but there was no statistically significant difference between them.

Conclusions
Our results revealed that there are some differences between the software packages that perform the segmentation and STL creation of the DICOM image data. In particular, the features of each software package appeared in the fine and thin areas of the osseous structures. When using these software packages, it is necessary to understand the characteristics of each.
Somatic cough syndrome: a report of two cases and review of literature
Authors: Bashtawi Mahmoud , Abuabada Amal , Aldabbour Belal 
Published: July 2020

Abstract
Background
Somatic cough syndrome is a somatization disorder that usually presents in children and which is often diagnosed late after an extensive search for organic causes. The condition was redefined by the DSM-5 criteria and grouped with the other conditions under the umbrella of somatoform disorders. Nonetheless, clinical presentation is heterogeneous, and etiology is still not clearly defined. Several management approaches have been proposed, but treatment remains essentially nonpharmacological.

Case presentation
We report two cases of somatic cough syndrome that were diagnosed after 4 years and 3 months respectively, and document the successful treatment of both cases using behavioral therapy.

Discussion
Behavioral therapy is the most reportedly successful nonpharmacological treatment in somatic cough syndrome, and it was successful with both our cases. The condition poses a significant burden over the function and quality of life in patients and their caregivers. The heterogeneous nature of this syndrome necessitates a high index of suspicion on part of both the physician and the psychiatrist in order to secure a timely diagnosis and mitigate the impact of this condition.
A flexible ICT architecture to support ancillary services in future electricity distribution networks: an accounting use case for DSOs
Authors: Jindal Anish , Kronawitter Jakob , Kühn Ramona , Bor Martin , de Meer Hermann , Gouglidis Antonios , Hutchison David , Marnerides Angelos K. , Scott Andrew , Mauthe Andreas 
Published: July 2020

AbstractWith the increased penetration of distributed renewable energy sources (DRES) in the grid, new pathways are required to keep the electricity distribution system stable. The provision of ancillary services (AS) by the DRES can contribute in this regard. However, it is necessary to communicate the need for AS from the third party providers such as distribution system operator (DSO) to the DRES in an efficient and scalable manner. To this end, a flexible information and communication technology (ICT) architecture is presented in this paper, and the requirements for the architecture are elaborated. We argue that this architecture is capable of supporting the present and future needs of electricity distribution networks. To illustrate its utility and effectiveness, an accounting use case for DSOs has been presented; it describes a remuneration scheme for the AS provision. A dashboard has been developed to enable communication via this architecture and to allow control of the grid. In addition, a distributed ledger technology for the realization of accounting has been analysed with respect to its scalability and performance capabilities.
Flexible thermoplastic starch films functionalized with copper particles for packaging of food products
Authors: López Olivia V. , Villanueva María E. , Copello Guillermo J. , Villar Marcelo A. 
Published: July 2020

AbstractBiodegradable films based on thermoplastic corn starch (TPS) and copper particles with antimicrobial capacity were developed. Copper nanoparticles (Cu) and silica coated copper microparticles (Si-Cu) in the range of 0.25 to 5% were used. Composite films were obtained by melt-mixing and subsequent thermo-compression. Particles distribution within TPS matrix and the presence of some pores and cracks, induced by Si-Cu particles, was evaluated by SEM. The presence of both fillers gave composite films a brown pigmentation and decreased their transparency; these effects were more pronounced at higher particles concentrations. Regarding mechanical properties, copper particles at 1 and 5% acted as reinforcing agents increasing the maximum tensile strength but their presence lead to a decrease in elongation at break, affecting films ductility. Composites inhibited the growth of Gram+ and Gram- bacteria, demonstrating their antimicrobial capacity. Copper effectively migrated to a simulant of aqueous foods and naked particles concentration in the simulant medium resulted higher than the minimum inhibitory concentration for bacteria. The characteristics and properties of developed composite films make them an interesting material for food primary packaging, mainly for meat fresh products.
Fumigant toxicity and phytochemical analysis of Petiveria alliacea (Linneaus) leaf and root bark oil on adult Culex quinquefasciatus
Authors: Akintan Michael Olarewaju , Akinneye Joseph Onaolapo 
Published: July 2020

Abstract
Background
Culex mosquitoes are a major vector of public health importance and have been implicated for the transmission of some parasitic diseases such as lymphatic filariasis and West Nile virus. It has also been reported to cause several problems which include developing resistance to synthetic insecticides, thus, necessitating the search for an insecticide of botanical origin which is bio-degradable, non-toxic, and readily available for man’s use. This study aimed to evaluate the phytochemicals present in Petiveria alliacea and the fumigant efficacy of its oil extract against the adult stage of Culex quinquefasciatus.

Results
The result obtained shows that the oil extract of Petiveria alliacea at all concentrations had a significant effect on the adult mosquito for fumigant toxicity with percentage mortality range of 75.00–100% within a 2-h exposure period (P < 0.05) for the leaf extract and 81.67–100% mortality for the root bark extract. The synergistic effect of the leaf and root bark oil was also investigated. The lethal concentration (LC50) of the leaf, root, and synergistic effect of leaf and root oil extract required to kill 50% of the adult Culex quinquefasciatus was 0.45 ml, 0.53 ml, and 0.47 ml, respectively. However, 2.20 ml, 1.194 ml, and 1.15 ml of the leaf, root, and leaf and root oil extract were required to kill 90% (LC90) after a 2-h exposure period. A total of 29 organic compounds were isolated from leaf and root bark oil of the plant. The study has revealed that the leaves and root bark of Petiveria alliacea are rich in phytochemicals

Conclusion
These findings suggested Petiveria alliacea oil extract could be a good source of insecticide which may be used for the production of biopesticides. The present findings have important implications in the practical control of adult mosquito by using botanical insecticides. These plant extracts are easy to prepare, inexpensive, and safe for mosquito control which possesses enough insecticidal potential and can be used directly around human dwellings. The result suggests possible utilization of the cheap and readily available botanicals for possible control of mosquitoes as part of an integrated vector management programme.
A preliminary study: MUC5B promoter polymorphism and its association with IPF
Authors: Yusuf Hoda Ali Abu , Galal Mohamed , Kaddah Safy , el Sharkawy Marwa , Mousa Mohamed Shaaban , Moussa Heba 
Published: July 2020

Abstract
Background
The (T) allele of MUC5B gene is strongly correlated with idiopathic pulmonary fibrosis (IPF) and interstitial lung diseases (ILD) related to autoimmune conditions in Caucasians, but no data is available regarding this polymorphism in the Egyptian patients.

Results
This study is an observational cross-sectional study; the percentage of the (T) allele of MUC5B gene promoter in normal Egyptian persons in this study was 20%. This polymorphism is strongly related with risk for development of UIP/IPF in Egyptian patients compared to the other 2 groups (P value < 0.001). The MUC5B polymorphism has no role for developing interstitial lung disease in autoimmune diseases.

Conclusions
This study showed the potential role of MUC5B promoter polymorphism in IPF patients. Further multicentric studies are essential to be conducted deploying larger cohorts and different ethnic populations for further evaluation of these polymorphisms correlation.
Sterilization Rate of the Axilla After Neoadjuvant Chemotherapy: The Scope for Conservative Surgery
Authors: Noronha Jarin , Joshi Shalaka , Hawaldar Rohini , Nair Nita , Vanmali Vaibhav , Parmar Vani , Shet Tanuja , Badwe Rajendra 
Published: July 2020

PURPOSE The role of axillary conservation after neoadjuvant chemotherapy (NACT) is debatable. We routinely carry out complete axillary lymph node dissection (ALND). This study was conducted to understand the pathologic axillary complete response (pAxCR) after NACT. MATERIALS AND METHODS We evaluated a prospective database of patients with breast cancer who underwent surgery after NACT in the year 2017 at our institution. NACT was administered to downstage locally advanced breast cancer or facilitate breast-conservation surgery. RESULTS Of 793 patients who underwent surgery after NACT, 97(12.2%) had cN0 disease, 407 (51.3%) had cN1, 262 (32%) had cN2, and 27 (3.4%) had cN3 at presentation. Eighty-eight patients (11.1%) had cT1-2 primary tumor stage, and 623 patients (78.6%) had cT3-4 primary tumor stage; primary tumor stage details were unavailable for 82 patients (10.3%). The median age was 46 years (range, 21-74 years). On histopathology, the overall pAxCR rate was 52.8%. In the cN1 and cN2 settings, 58.7% and 36.6% of patients achieved ypN0 status, respectively. The overall pathologic complete response rate was 22.64% (161 of 711 patients). On univariable analysis, cN stage, histologic grade, hormone receptor status, NACT duration, and lymphovascular invasion were significantly associated with pAxCR ( P <.001). On logistic regression, prechemotherapy cN status (odds ratio [OR], 3.08; 95% CI, 2.18 to 4.37; P <.001), estrogen and progesterone receptor status (OR, 0.34; 95% CI, 0.3 to 0.4; P <.001), and administration of both chemotherapy regimens preoperatively (OR, 0.66; 95% CI, 0.45 to 0.97; P <.05) predicted pAxCR. CONCLUSION At least half of patients with cN1 and a third of patients with cN2 breast cancer who develop pAxCR may be suitable candidates for axillary conservation. A careful postchemotherapy assessment followed by a conservative axillary procedure may be an alternative to ALND, but this needs to be studied prospectively.
Length of Stay and Hospital Costs for Patients Undergoing Allogeneic Stem-Cell Transplantation
Authors: Godara Amandeep , Siddiqui Nauman S. , Munigala Satish , Dhawan Rishi , Kansagra Ankit J. , Rapoport Aaron P. , Yared Jean A. , Dahiya Saurabh 
Published: July 2020

PURPOSE: Patients who undergo allogeneic hematopoietic stem-cell transplantation (allo-HSCT) usually require a prolonged hospital stay that varies greatly across patients. Limited information exists on the factors associated with hospital length of stay (LOS) after allo-HSCT and the impact on transplant-related costs. The objective of this study was to determine predictors for longer LOS for allo-HSCT and to assess their impact on the cost of transplant stay. METHODS: Using the National Inpatient Sample database, adult patients hospitalized for allo-HSCT were identified using International Classification of Diseases, Ninth Revision, primary and secondary procedure codes. RESULTS: Between 2002 and 2015, 68,296 hospitalizations for allo-HSCT were identified. Peripheral blood was the most common stem-cell source (80%) followed by bone marrow (15%) and cord blood (5%). Median LOS was 25.8 days (interquartile range [IQR], 21-34.0 days), and the overall inpatient mortality rate was 8%. Stem-cell source was a significant predictor for longer LOS, being significantly longer for cord blood (median, 36.9 days; IQR, 26.7-49.9 days) compared with bone marrow (median, 27.2 days; IQR, 21.5-35.2 days) and peripheral blood (median 25.4 days; IQR, 20.8-32.7 days). Other predictors for longer LOS were patient characteristics such as age and race, transplant/post-transplant characteristics, and complications such as total body irradiation use, acute graft-versus-host disease, and infections. Longer LOS was also found to be associated with higher hospital costs. CONCLUSION: In patients who undergo allo-HSCT, LOS can be predicted using patient- and transplant-related characteristics as well as post-transplant complications. LOS is also a driver for increased cost, and further efforts are needed to mitigate transplant complications and resource utilization.
Transversus Abdominis Plane Block With Liposomal Bupivacaine for Pain After Cesarean Delivery in a Multicenter, Randomized, Double-Blind, Controlled Trial
Authors: Nedeljkovic Srdjan S. , Kett Attila , Vallejo Manuel C. , Horn Jean-Louis , Carvalho Brendan , Bao Xiaodong , Cole Naida M. , Renfro Leslie , Gadsden Jeffrey C. , Song Jia , Yang Julia , Habib Ashraf S. 
Published: July 2020

BACKGROUND:
In women undergoing cesarean delivery under spinal anesthesia with intrathecal morphine, transversus abdominis plane (TAP) block with bupivacaine hydrochloride (HCl) may not improve postsurgical analgesia. This lack of benefit could be related to the short duration of action of bupivacaine HCl. A retrospective study reported that TAP block with long-acting liposomal bupivacaine (LB) reduced opioid consumption and improved analgesia following cesarean delivery. Therefore, we performed a prospective multicenter, randomized, double-blind trial examining efficacy and safety of TAP block with LB plus bupivacaine HCl versus bupivacaine HCl alone.

METHODS:
Women (n = 186) with term pregnancies undergoing elective cesarean delivery under spinal anesthesia were randomized (1:1) to TAP block with LB 266 mg plus bupivacaine HCl 50 mg or bupivacaine HCl 50 mg alone. Efficacy was evaluated in a protocol-compliant analysis (PCA) set that was defined a priori. The primary end point was total postsurgical opioid consumption (oral morphine equivalent dosing [MED]) through 72 hours. Pain intensity was measured using a visual analog scale. Adverse events (AEs) after treatment were recorded through day 14.

RESULTS:
Total opioid consumption through 72 hours was reduced with LB plus bupivacaine HCl versus bupivacaine HCl alone (least squares mean [LSM] [standard error (SE)] MED, 15.5 mg [6.67 mg] vs 32.0 mg [6.25 mg]). This corresponded to an LSM treatment difference of −16.5 mg (95% confidence interval [CI], −30.8 to −2.2 mg; P = .012). The area under the curve of imputed pain intensity scores through 72 hours supported noninferiority of LB plus bupivacaine HCl versus bupivacaine HCl alone (LSM [SE], 147.9 [21.13] vs 178.5 [19.78]; LSM treatment difference, −30.6; 95% CI, −75.9 to 14.7), with a prespecified noninferiority margin of 36 (P = .002). In an analysis of all treated patients, including those not meeting criteria for inclusion in the PCA, there was no difference in postsurgical opioid consumption between groups. In the LB plus bupivacaine HCl group, 63.6% of patients experienced an AE after treatment versus 56.2% in the bupivacaine HCl–alone group. Serious AEs after treatment were rare (≈3% in both groups).

CONCLUSIONS:
TAP block using LB plus bupivacaine HCl as part of a multimodal analgesia protocol incorporating intrathecal morphine resulted in reduced opioid consumption after cesarean delivery in the PCA set. Results suggest that with correct TAP block placement and adherence to a multimodal postsurgical analgesic regimen, there is an opioid-reducing benefit of adding LB to bupivacaine TAP blocks after cesarean delivery (ClinicalTrials.gov identifier: NCT03176459).
Of Taming Carnal Desire
Authors: Debele Serawit B. 
Published: July 2020

AbstractFocusing on Ethiopia, an empire off-center, this article argues against dominant narratives that link the regulation of sexual practices to colonial (Western) imperial relations. Within this context, the paper investigates struggles over the past by contrasting two versions of history, discussing how different groups mobilize the past in contemporary Ethiopia. It begins by exploring the imperial, Christian roots of the country’s penal codes, interrogating how the state mobilizes such histories to criminalize same-sex desires and practices. The article then focuses its attention on those deemed “outlaws” by such legislation, exploring their search for histories silenced by empire, and their assertion as longstanding, integral parts of the country’s past.
The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways
Authors: Gubar Olga , Croisé Pauline , Kropyvko Sergii , Gryaznova Tetyana , Tóth Petra , Blangy Anne , Vitale Nicolas , Rynditch Alla , Gasman Stéphane , Ory Stéphane 
Published: July 2020

ABSTRACT
Rho GTPases play a key role in various membrane trafficking processes. RhoU is an atypical small Rho GTPase related to Rac/Cdc42, which possesses unique N- and C-terminal domains that regulate its function and its subcellular localization. RhoU localizes at the plasma membrane, on endosomes and in cell adhesion structures where it governs cell signaling, differentiation and migration. However, despite its endomembrane localization, RhoU function in vesicular trafficking has been unexplored. Here, we identified intersectins (ITSNs) as new binding partners for RhoU and showed that the second PxxP motif at the N terminus of RhoU mediated interactions with the SH3 domains of ITSNs. To evaluate the function of RhoU and ITSNs in vesicular trafficking, we used fluorescent transferrin as a cargo for uptake experiments. We showed that silencing of either RhoU or ITSN2, but not ITSN1, increased transferrin accumulation in early endosomes, resulting from a defect in fast vesicle recycling. Concomitantly, RhoU and ITSN2 colocalized to a subset of Rab4-positive vesicles, suggesting that a RhoU–ITSN2 interaction may occur on fast recycling endosomes to regulate the fate of vesicular cargos.
Pulmonary thromboembolism in hospitalised COVID-19 patients at moderate to high risk by Wells score: a report from Lombardy, Italy
Authors: Monfardini Lorenzo , Morassi Mauro , Botti Paolo , Stellini Roberto , Bettari Luca , Pezzotti Stefania , Alì Marco , Monaco Cristian Giuseppe , Magni Veronica , Cozzi Andrea , Schiaffino Simone , Bnà Claudio 
Published: July 2020

Objectives:
To present a single-centre experience on CT pulmonary angiography (CTPA) for the assessment of hospitalised COVID-19 patients with moderate-to-high risk of pulmonary thromboembolism (PTE).

Methods:
We analysed consecutive COVID-19 patients (RT-PCR confirmed) undergoing CTPA in March 2020 for PTE clinical suspicion. Clinical data were retrieved. Two experienced radiologists reviewed CTPAs to assess pulmonary parenchyma and vascular findings.

Results:
Among 34 patients who underwent CTPA, 26 had PTE (76%, 20 males, median age 61 years, interquartile range 54–70), 20/26 (77%) with comorbidities (mainly hypertension, 44%), and 8 (31%) subsequently dying. Eight PTE patients were under thromboprophylaxis with low-molecular-weight heparin, four PTE patients had lower-limbs deep vein thrombosis at ultrasound examination (performed in 33/34 patients). Bilateral PTE characterised 19/26 cases, with main branches involved in 10/26 cases. Twelve patients had a parenchymal involvement &gt;75%, the predominant pneumonia pattern being consolidation in 10/26 patients, ground glass opacities in 9/26, crazy paving in 5/26, and both ground glass opacities and consolidation in 2/26.

Conclusion:
COVID-19 patients are prone to PTE.

Advances in knowledge:
PTE, potentially attributable to an underlying thrombophilic status, may be more frequent than expected in COVID-19 patients. Extension of prophylaxis and adaptation of diagnostic criteria should be considered.