bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probabilistic Contingency Tables: An Improvement to Verify Probability Forecasts
Authors: Gold Sarah , White Edward , Roeder William , McAleenan Mike , Kabban Christine Schubert , Ahner Darryl 
Published: February 2020

Abstract
The 45th Weather Squadron (45 WS) records daily rain and lightning probabilistic forecasts and the associated binary event outcomes. Subsequently, they evaluate forecast performance and determine necessary adjustments with an established verification process. For deterministic outcomes, weather forecast analysis typically utilizes a traditional contingency table (TCT) for verification; however, the 45 WS uses an alternative tool, the probabilistic contingency table (PCT). Using the TCT for verification requires a threshold, typically at 50%, to dichotomize probabilistic forecasts. The PCT maintains the valuable information in probabilities and verifies the true forecasts being reported. Simulated forecasts and outcomes as well as 2015–18 45 WS data are utilized to compare forecast performance metrics produced from the TCT and PCT to determine which verification tool better reflects the quality of forecasts. Comparisons of frequency bias and other statistical metrics computed from both dichotomized and continuous forecasts reveal misrepresentative performance metrics from the TCT as well as a loss of information necessary for verification. PCT bias better reflects forecast verification in contrast to that of TCT bias, which suggests suboptimal forecasts when in fact the forecasts are accurate.
Regional Thermodynamic Characteristics Distinguishing Long- and Short-Duration Freezing Rain Events over North America
Authors: McCray Christopher D. , Gyakum John R. , Atallah Eyad H. 
Published: February 2020

Abstract
Freezing rain is an especially hazardous winter weather phenomenon that remains particularly challenging to forecast. Here, we identify the salient thermodynamic characteristics distinguishing long-duration (six or more hours) freezing rain events from short-duration (2–4 h) events in three regions of the United States and Canada from 1979 to 2016. In the northeastern United States and southeastern Canada, strong surface cold-air advection is not common during freezing rain events. Colder onset temperatures at the surface and in the near-surface cold layer support longer-duration events there, allowing heating mechanisms (e.g., the release of latent heat of fusion when rain freezes at the surface) to act for longer periods before the surface reaches 0°C and precipitation transitions to rain. In the south-central United States, cold air at the surface is replenished via continuous cold-air advection, reducing the necessity of cold onset surface temperatures for event persistence. Instead, longer-duration events are associated with warmer and deeper &gt;0°C warm layers aloft and stronger advection of warm and moist air into this layer, delaying its erosion via cooling mechanisms such as melting. Finally, in the southeastern United States, colder and especially drier onset conditions in the cold layer are associated with longer-duration events, with evaporative cooling crucial to maintaining the subfreezing surface temperatures necessary for freezing rain. Through an improved understanding of the regional conditions supporting freezing rain event persistence, we hope to provide useful information to forecasters in their attempt to predict these potentially damaging events.
Modified one-session endovascular treatment for deep venous thrombosis with high risk of pulmonary embolism: Short-term outcomes
Authors: Li Wei , Yin Yu , Gu Chengtao , Fan Baorui , Duan Pengfei , Jin Yonghai , Ni Caifang 
Published: February 2020

Objectives To evaluate the safety and short-term outcomes of the modified one-session endovascular treatment with inferior vena cava filter placement and retrieval in one stage for the treatment of acute lower extremity deep vein thrombosis. Method Twenty-three patients with unilateral acute lower extremity deep vein thrombosis underwent modified one-session endovascular treatments, which were performed in one stage. Inferior vena cava filter placement without detachment, thrombectomy, and inferior vena cava filter retrieval were performed in one stage. Angioplasty and stent implantation were performed for patients with iliac vein stenosis. Venography was performed to identify the clearance of the thrombus. Color Doppler ultrasound and/or venography were conducted during the follow-up. Results A total of 20/23 (87%) patients with thrombus removal rate >90% successfully underwent modified one-session endovascular treatment. inferior vena cava filters were detached in 3/23 (13%) patients achieving 50%–90% thrombus removal rate. Twenty-one iliac vein stents were implanted in 21/23 (91%) patients with iliac vein stenosis. After treatment, the differences in the circumferences of the affected limb and the healthy limb both significantly decreased. No procedure-related death, symptomatic pulmonary embolism, or major bleeding occurred. During the 12–25 months of follow-up, iliac vein stents and lower extremity veins maintained patent. Conclusions The modified one-session endovascular treatment with one-stage inferior vena cava filter placement and retrieval might be safe for the treatment of acute lower extremity deep vein thrombosis, and the early clinical outcomes are satisfactory. Placing and retrieving an inferior vena cava filter in one session could safeguard the endovascular interventions as well as reduce the filter-related complications associated with long dwelling times.
Tension-free mesh repair of inguinal hernia in patients on continuous ambulatory peritoneal dialysis
Authors: Luk Yan , Li Jason Yu Yin , Law Tsz Ting , Ng Lily , Wong Kin Yuen 
Published: February 2020

Background: Peritoneal dialysis (PD) is the first-line renal replacement therapy for end-stage renal failure patients in Hong Kong. Abdominal wall hernia is a common mechanical complication of PD, and early surgical repair has been advocated to reduce complications. This study aims to review the outcomes of tension-free mesh repair of inguinal hernia in PD patients. Methods: All PD patients who underwent elective repair of inguinal hernia from 2009 to 2015 were identified from a single centre for retrospective analysis. Primary outcomes included surgical complications, perioperative dialysis technique and recurrence. Results: Twenty-one patients with a total of 26 inguinal hernia repairs were included in this 7-year retrospective study. All were males, and the mean age was 68 ± 10 years. Diabetic nephropathy ( n = 9, 42.9%) and glomerulonephritis ( n = 7, 33.3%) were the two most common causes of renal failure. All hernias were detected after the initiation of PD, and the mean duration of PD to hernia detection was 16 months (range 1–65 months). Lichtenstein open mesh repair was performed in all patients. Complications included seroma ( n = 3, 11.5%) and ischaemic orchitis ( n = 1, 3.8%). There were no mesh infection or recurrence. Twenty patients (95.2%) received intermittent peritoneal dialysis post-operatively and returned to continuous ambulatory PD in 15 to 30 days. Only one patient (4.8%) required bridging haemodialysis due to Tenckhoff catheter blockage. Conclusions: Tension-free mesh repair is associated with low morbidity and low recurrence rates in PD patients. Timely management and close collaboration with renal physicians are essential to continue PD after repair.
Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis
Authors: Davies Simon J , Finkelstein Fredric O 
Published: February 2020

Background: Current guidelines for the prescription of peritoneal dialysis dose rely on a single cut-off ‘minimal’ value of K t/ V. To apply this in the clinic, this requires an accurate estimation of V, the volume of urea distribution that equates to the total body water (TBW). This analysis sought to determine the accuracy to which V can be estimated. Methods: A literature search was undertaken of studies comparing TBW estimation using two or three of the following methods: isotopic dilution (gold standard), anthropometric equations (e.g. Watson formula) and bioimpedance analysis. Studies of healthy and dialysis populations of all ages were included. Mean differences and 95% limits of agreement (LOA) were extracted and pooled. Results: In 44 studies (31 including dialysis subjects), the between-method population means were typically within 1–1.5 L of each other, although larger bias was seen when applying anthropometric equations to different racial groups. However, the 95% LOA for all comparisons were consistently wide, typically ranging ±12–18% of the TBW. For a typical individual whose TBW is 35 L with a measured K t/ V of 1.7, this translates into a range of K t/ V 1.4–2.05. Conclusions: There are limitations to the accuracy of estimation of V which call into question the validity of applying a single threshold K t/ V value as indicative of adequate dialysis. This should be taken into account in guideline development such that if a target K t/ V was deemed appropriate that this should be expressed as a range; alternatively single targets should be avoided and dialysis dose should be determined according to patient need.
Advanced Stage of Disease and Systemic Inflammation as Factors Associated With Referral of Patients With Colorectal Cancer to a Palliative Care Unit
Authors: Silva Thiago Huaytalla , Peres Wilza Arantes Ferreira , Rosa Karla Santos da Costa , Schilithz Arthur Orlando Correa , de Oliveira Livia Costa , Murad Leonardo Borges 
Published: February 2020

Objective: To identify factors associated with referral to an exclusive palliative care unit (PCU) in patients with colorectal cancer (CRC). Methods: Retrospective cohort study with patients having CRC of both sexes treated at a hospital unit, aged ≥20 years. Data were extracted from the medical records of pretreatment patients between January 2008 and August 2014. The outcome was referral to the PCU within 5 years. Logistic regression analyses were performed to assess whether sociodemographic, clinical, nutritional, and biochemistry data were associated to referral, generating odds ratios (OR), and 95% confidence intervals (CI). Results: Four hundred fifteen patients were evaluated. The Patient-Generated Subjective Global Assessment demonstrated a prevalence of malnutrition of 57.3%. One hundred one (24.3%) patients were referred to the PCU after 16.3 months (interquartile range: 7.2-33.5). These patients were more likely to be at an advanced stage of the disease and have malnutrition and exacerbated systemic inflammation. Tumor stage III and IV (OR: 2.05; 95% CI: 1.12-3.76) and neutrophil-to-lymphocyte ratio (NLR) ≥3 (OR: 1.89; 95% CI: 1.12-3.17) were predictors of an increased chance of referral to the PCU. Conclusion: Advanced disease stage and NLR were associated with referral of patients with CCR to a PCU.
The effect of viewing idealised smile images versus nature images via social media on immediate facial satisfaction in young adults: A randomised controlled trial
Authors: Sampson Ariane , Jeremiah Huw G , Andiappan Manoharan , Newton J Tim 
Published: February 2020

Introduction: The objective of this randomised controlled trial (RCT) is to investigate the effect of a social networking site (SNS) on body dissatisfaction, facial and smile dissatisfaction, and face-related discrepancy, and whether these effects differ from the use of appearance-neutral Instagram images. We also aimed to investigate whether there are trends in increased self-reported use of social media and increased body dissatisfaction, facial and smile dissatisfaction, and face-related discrepancy. Methods: Undergraduate students were randomly allocated to an experimental group with idealised smile images or to a control group with neutral nature images. They completed pre-exposure questionnaires, then perused for 5 min their allocated images on individual Apple iPads via the Instagram application. Participants then completed the post-exposure surveys. The main outcome was facial dissatisfaction. Body dissatisfaction and total facial and body dissatisfaction were secondary outcomes. Simple randomisation was achieved with a computerised random number generator. Data were analysed using repeated measures ANOVA and multivariate regression analyses. Results: A total of 132 participants (mean age = 20.50 ± 2.21 years) were randomised to either the experimental group with idealised smile images (n=71) or the control group with neutral nature images (n=61). Baseline characteristics were similar between groups and no participants were lost. Exposure to ‘ideal’ facial images on social media decreases facial satisfaction (95% confidence interval [CI] = 0.85–1.05; P < 0.0001). Individuals with high baseline self-discrepancy scores are less satisfied with their facial features and body appearance (95% CI = 0.04–1.16; P = 0.036). Conclusion: This study shows that viewing SNSs with high visual media reduces satisfaction with facial appearance in the short term in men and women. This effect is greater in those with high self-discrepancy scores. Increased media usage was not correlated with increased dissatisfaction. Wearing braces or having had braces was shown not to influence post-exposure dissatisfaction.
Patient experience of preheated and room temperature skin disinfection prior to cardiac device implantation: A randomised controlled trial
Authors: Wistrand Camilla , Nilsson Ulrica , Sundqvist Ann-Sofie 
Published: February 2020

Background: Clinically, patients often comment on the coolness of the skin disinfectant. However, scarce evidence is available regarding patients’ experience during intraoperative skin disinfection. Aims: The aim of this study was to describe and compare intraoperative patient experiences with preheated and room temperature skin disinfectant. Method: This randomised controlled trial included 220 patients undergoing cardiac device implantation. Patients allocated to preheated (36°C) or room temperature (20°C) chlorhexidine in 70% ethanol verbally answered an open-ended question regarding their experience with the skin disinfection. Results were assessed using a qualitative approach with comparative quantification. Results: The analysis resulted in nine categories describing the patients’ experiences with preheated and room temperature skin disinfection. Most of the patients described the skin disinfection process as a negative experience, which consisted of six categories: cold, smell, change in temperature, unpleasant, wet and painful. In addition, two neutral categories of response (nothing in particular and neither pleasant nor unpleasant) and one positive response (pleasant) emerged through the analysis. Preheated skin disinfection yielded significantly fewer negative experiences in the category cold (85% vs. 15%, P<0.0001) and significantly more positive experiences (66% vs. 34%, P<0.002). Neutral categories (neither pleasant nor unpleasant 65% vs. 35%, P=0.01, nothing in particular 74% vs. 26%, P<0.001) dominated after preheated skin disinfection. Conclusion: The use of preheated skin disinfection promotes a positive patient experience with skin disinfection. Trial registration: ClinicalTrials.gov registration number NCT02260479 ( https://clinicaltrials.gov/ct2/results?cond=preheated+skin+disinfection ).
A systematic review and meta-analysis of Woven EndoBridge single layer for treatment of intracranial aneurysms
Authors: van Rooij SBT , Sprengers ME , Peluso JP , Daams J , Verbaan D , van Rooij WJ , Majoie CB 
Published: February 2020

Background and purpose The Woven EndoBridge is an intrasaccular device for the treatment of intracranial aneurysms. The first generation consisted of a high-profile double-layer braid. This review aims to evaluate the outcomes of the new generation low-profile Woven EndoBridge single layer device for intracranial aneurysm treatment. Methods A systematic review was conducted with Medline, Embase, and Web of Science Conference Proceedings databases. The search strategy provided 589 articles, 15 articles were included. Results Fifteen articles were identified reporting the use of Woven EndoBridge single-layer devices in 963 aneurysms, mostly wide-necked bifurcation aneurysms. Procedural aneurysm rupture was reported in 8 of 963 patients (0.83%; 95%CI 0.39–1.66%) and thromboembolic events in 54 of 963 patients (5.61%, 95CI 4.31–7.26%). Cumulative morbidity was 2.85% (27/949, 95%CI 1.95–4.12%) and mortality 0.93% (9/963, 95%CI 0.46–1.80%). The overall rate of adequate aneurysm occlusion at last follow-up was 83.3% (613/736; 95%CI 80.4–85.8%). Retreatment was reported in 38 aneurysms in eight studies with 450 aneurysms with follow-up (38/450; 8.4%, 95CI 6.2–11.4%). In 12 studies comprising 644 aneurysms with follow-up, rebleeds occurred in three patients in three studies with mean follow-up between 3.3 and 14.4 months (0.47%, 95%CI 0.09–1.43%) Conclusion Woven EndoBridge single-layer is a promising new low-profile device especially for wide-neck bifurcation aneurysms, both ruptured and unruptured. No antiplatelet medication is needed which is a great advantage, especially in ruptured aneurysms. Efficacy and safety compare favorably with (stent-assisted) coiling. However, no direct comparison with other treatments is available as yet.
The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine
Authors: Warfvinge Karin , Krause Diana , Edvinsson Lars 
Published: February 2020

Abstract
Background
Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology.
In order to better understand possible central actions of OT in migraine/headache pathogenesis, we mapped the distribution of OT and OTR in nerve cells and fibers in rat brain with a focus on areas related to migraine attacks and/or shown previously to contain calcitonin gene related peptide (CGRP), another neuropeptide involved in migraine.

Methods
Distribution of OT and OTR in the adult, rat brain was qualitatively examined with immunohistochemistry using a series of well characterized specific antibodies.

Results
As expected, OT was extensively localized in the cell somas of two hypothalamic nuclei, the supraoptic (SO or SON) and paraventricular nuclei (Pa or PVN). OT also was found in many other regions of the brain where it was localized mainly in nerve fibers. In contrast, OTR staining in the brain was mainly observed in cell somas with very little expression in fibers. The most distinct OTR expression was found in the hippocampus, the pons and the substantia nigra. In some regions of the brain (e.g. the amygdala and the hypothalamus), both OT and OTR were expressed (match). Mismatch between the peptide and its receptor was primarily observed in the cerebral and cerebellar cortex (OT expression) and hippocampus (OTR expression).

Conclusions
We compared OT/OTR distribution in the CNS with that of CGRP and identified regions related to migraine. In particular, regions suggested as “migraine generators”, showed correspondence among the three mappings. These findings suggest central OT pathways may contribute to the role of the hypothalamus in migraine attacks.
Microplastics in surface water and sediments of Chongming Island in the Yangtze Estuary, China
Authors: Li Yubo , Lu Zhibo , Zheng Hongyuan , Wang Juan , Chen Cheng 
Published: February 2020

Abstract
Background
The Yangtze Estuary acts as gateways where microplastics transport from freshwater into marine environments, with one of the largest discharge volumes in the world. The occurrence of microplastics in surface water and sediments of the Yangtze Estuary has been reported. However, little is known about microplastics in and around Chongming Island in the estuary. In this study, the distribution of microplastics in surface water and sediments of Chongming Island was investigated and compared in different environmental medium.

Results
Abundances of microplastics in surface water and sediments were in the ranges of 0–259 items m− 3 and 10–60 items kg− 1 dry weight, respectively. Microplastics were more abundant in the surface water of the Yangtze River shores than in the inland rivers (p < 0.01). Proportions in fiber form in surface water and sediment were 33% and 67%; and those in fragment form were 39% and 24%. Most particles (> 72%) were < 1 mm in the longest dimension; 65% were white and 30% were transparent. Of the 11 compositions identified, polyethylene, polypropylene, and α-cellulose predominated in both phases.

Conclusion
This is the first study to focus on microplastics in inland watercourses on Chongming Island and along the Yangtze River’s shores in both phases. There were differences between the island and estuary in composition and density due to the distinct vertical mixing processes. The in situ filtration of surface water (100 L) sampling method was well employed in various freshwater environments and free of plastic materials in front of the filter, analysis results of which provided an important baseline reference for evaluating microplastic pollution in the Yangtze Estuary.
RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio
Authors: Saddala Madhu Sudhana , Lennikov Anton , Bouras Adam , Huang Hu 
Published: February 2020

Abstract
Background
Retinal degenerative diseases affect millions of people and represent the leading cause of vision loss around the world. Retinal degeneration has been attributed to a wide variety of causes, such as disruption of genes involved in phototransduction, biosynthesis, folding of the rhodopsin molecule, and the structural support of the retina. The molecular pathogenesis of the biological events in retinal degeneration is unclear; however, the molecular basis of the retinal pathological defect can be potentially determined by gene-expression profiling of the whole retina. In the present study, we analyzed the differential gene expression profile of the retina from a wild-type zebrafish and phosphodiesterase 6c (pde6c) mutant.

Results
The datasets were downloaded from the Sequence Read Archive (SRA), and adaptors and unbiased bases were removed, and sequences were checked to ensure the quality. The reads were further aligned to the reference genome of zebrafish, and the gene expression was calculated. The differentially expressed genes (DEGs) were filtered based on the log fold change (logFC) (±4) and p-values (p < 0.001). We performed gene annotation (molecular function [MF], biological process [BP], cellular component [CC]), and determined the functional pathways Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for the DEGs. Our result showed 216 upregulated and 3527 downregulated genes between normal and pde6c mutant zebrafish. These DEGs are involved in various KEGG pathways, such as the phototransduction (12 genes), mRNA surveillance (17 genes), phagosome (25 genes), glycolysis/gluconeogenesis (15 genes), adrenergic signaling in cardiomyocytes (29 genes), ribosome (20 genes), the citrate cycle (TCA cycle; 8 genes), insulin signaling (24 genes), oxidative phosphorylation (20 genes), and RNA transport (22 genes) pathways. Many more of all the pathway genes were down-regulated, while fewer were up-regulated in the retina of pde6c mutant zebrafish.

Conclusions
Our data strongly indicate that, among these genes, the above-mentioned pathways’ genes as well as calcium-binding, neural damage, peptidase, immunological, and apoptosis proteins are mostly involved in the retinal and neural degeneration that cause abnormalities in photoreceptors or retinal pigment epithelium (RPE) cells.