bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epithelial barrier function properties of the 16HBE14o- human bronchial epithelial cell culture model
Authors: Callaghan Patrick J. , Ferrick Bryan , Rybakovsky Elizabeth , Thomas Sunil , Mullin James M. 
Published: September 2020

Abstract
The human bronchial epithelial cell line, 16HBE14o- (16HBE), is widely used as a model for respiratory epithelial diseases and barrier function. During differentiation, transepithelial electrical resistance (TER) increased to approximately 800 Ohms × cm2, while 14C-d-mannitol flux rates (Jm) simultaneously decreased. Tight junctions (TJs) were shown by diffusion potential studies to be anion-selective with PC1/PNa = 1.9. Transepithelial leakiness could be induced by the phorbol ester, protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), and the proinflammatory cytokine, tumor necrosis factor-α (TNF-α). Basal barrier function could not be improved by the micronutrients, zinc, or quercetin. Of methodological significance, TER was observed to be more variable and to spontaneously, significantly decrease after initial barrier formation, whereas Jm did not significantly fluctuate or increase. Unlike the strong inverse relationship between TER and Jm during differentiation, differentiated cell layers manifested no relationship between TER and Jm. There was also much greater variability for TER values compared with Jm. Investigating the dependence of 16HBE TER on transcellular ion conductance, inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel with GlyH-101 produced a large decrease in short-circuit current (Isc) and a slight increase in TER, but no significant change in Jm. A strong temperature dependence was observed not only for Isc, but also for TER. In summary, research utilizing 16HBE as a model in airway barrier function studies needs to be aware of the complexity of TER as a parameter of barrier function given the influence of CFTR-dependent transcellular conductance on TER.
Evidence of three mechanisms explaining the radius anomaly of hot Jupiters
Authors: Sarkis P. , Mordasini C. , Henning Th. , Marleau G. D. , Mollière P. 
Published: September 2020

Context. The anomalously large radii of hot Jupiters are still not fully understood, and all of the proposed explanations are based on the idea that these close-in giant planets possess hot interiors. Most of the mechanisms proposed have been tested on a handful of exoplanets.
Aims. We approach the radius anomaly problem by adopting a statistical approach. We want to infer the internal luminosity for the sample of hot Jupiters, study its effect on the interior structure, and put constraints on which mechanism is the dominant one.
Methods. We developed a flexible and robust hierarchical Bayesian model that couples the interior structure of exoplanets to the observed properties of close-in giant planets. We applied the model to 314 hot Jupiters and inferred the internal luminosity distribution for each planet and studied at the population level (i) the mass–luminosity–radius distribution and as a function of equilibrium temperature the distributions of the (ii) heating efficiency, (iii) internal temperature, and the (iv) pressure of the radiative–convective–boundary (RCB).
Results. We find that hot Jupiters tend to have high internal luminosity with 104 LJ for the largest planets. As a result, we show that all the inflated planets have hot interiors with an internal temperature ranging from 200 up to 800 K for the most irradiated ones. This has important consequences on the cooling rate and we find that the RCB is located at low pressures between 3 and 100 bar. Assuming that the ultimate source of the extra heating is the irradiation from the host star, we also illustrate that the heating efficiency increases with increasing equilibrium temperature and reaches a maximum of 2.5% at ~1860 K, beyond which the efficiency decreases, which is in agreement with previous results. We discuss our findings in the context of the proposed heating mechanisms and illustrate that ohmic dissipation, the advection of potential temperature, and thermal tides are in agreement with certain trends inferred from our analysis and thus all three models can explain various aspects of the observations.
Conclusions. We provide new insights on the interior structure of hot Jupiters and show that with our current knowledge, it is still challenging to firmly identify the universal mechanism driving the inflated radii.
Wirksamkeit manualtherapeutischer Techniken in Kombination mit vestibulärer Rehabilitation nach sportbedingten Gehirnerschütterungen – Eine systematische Übersichtsarbeit randomisiert kontrollierter Studien
Authors: Scheiber Barbara , Schiefermeier-Mach Natalia , Wiederin Claudia 
Published: September 2020

ZusammenfassungHintergrund Die Rehabilitation nach leichter, sportbedingter Gehirnerschütterung erfordert eine komplexe Behandlung unter Berücksichtigung der muskuloskelettalen, insbesondere zervikogenen, und vestibulären Beteiligung. Das empfohlene Rehabilitationskonzept der vollständigen Ruhe bis zur Beschwerdefreiheit wird inzwischen neu bewertet. Aktuelle Studien deuten auf positive Auswirkungen einer frühen Mobilisierung und multimodaler Physiotherapie hin. Der medizinische Nutzen ausgewählter manualtherapeutischer Techniken wird in mehreren klinischen Studien untersucht. Bisher konnten jedoch keine eindeutigen Empfehlungen für manualtherapeutische Techniken nach einer Gehirnerschütterung ausgesprochen werden.Ziel Analyse und Zusammenfassung vorhandener randomisiert kontrollierter Studien (RCTs) zur Untersuchung der Wirksamkeit manualtherapeutischer Techniken in Kombination mit vestibulärer Rehabilitation auf Symptomfreiheit und Wiedererlangung der sportlichen Belastbarkeit bei Patienten nach sportbedingten Gehirnerschütterungen.Methode Systematische Recherche in den Datenbanken ClinicalTrials.gov, WHO-ICTRP, EBSCO, PubMed und PEDro mit den Suchbegriffen concussion, physiotherapy, manual therapy und mild traumatic brain injury. Eingeschlossen wurden RCTs zur Untersuchung manualtherapeutischer Techniken nach sportbedingten Gehirnerschütterungen oder milden Formen eines Schädelhirntraumas. Die Bewertung der methodischen Qualität erfolgte Anhand der PEDro-Skala.Ergebnisse Publikationen zu 2 RCTs mit guter und moderater methodischer Qualität (PEDro-Skala: 7–8/10 Punkten) sowie eine Folgestudie wurden inkludiert. Als primärer Outcome-Parameter wurde in allen Studien der Zeitraum der ärztlichen Freigabe zur Rückkehr zum Sport angegeben. Sekundäre Outcome-Parameter bezogen sich auf Symptomfreiheit, Postconcussion Scale, Numeric Pain Rating Scale, Balance Confidence Scale, Dizziness-Handicap-Index, Sport Concussion Assessment Tool 2 und Joint-Position-Error-Test. Die Ergebnisse aller inkludierten Studien ergaben signifikante Unterschiede zugunsten der Interventionsgruppen. Die eingeschlossenen klinischen Studien waren jedoch in Bezug auf Design, Methodik und Auswahl der Techniken heterogen, was einen direkten Vergleich erschwerte.Schlussfolgerung Abgeschlossene klinische Studien deuten darauf hin, dass manualtherapeutische Techniken als Teil eines multimodalen Rehabilitationsprogramms nach Gehirnerschütterungen und leichten Schädelhirntraumata von Nutzen sein können. Aufgrund der geringen Anzahl an RCTs und deren heterogenen Studiendesigns ist eine Bewertung der Wirksamkeit spezifischer manualtherapeutischer Techniken derzeit nicht möglich. Weitere hochwertige Studien sind erforderlich.
Is Toxoplasma gondii Infection a Cause or a Coincidence in an Adolescent with Psychosis?
Authors: Yucel Hüsniye , Acikel Burak , Nur Öz F , Senel Saliha 
Published: September 2020

AbstractAlthough presumed to be relatively harmless in immunocompetent patients, toxoplasmosis has been linked to several psychiatric problems such as schizophrenia, bipolar disorder, and suicidal/aggressive behaviors. We describe an 11-year-old young adolescent girl with psychoses who was ultimately diagnosed with toxoplasmosis. It is an unusual presentation of Toxoplasma gondii infection that adds new knowledge to the current level of literature about the substantial role of Toxoplasma gondii in the etiology of neuropsychiatric diseases. We propose that screening for toxoplasmosis is needed besides other etiologies in differential diagnosis of psychiatric symptoms particularly in endemic areas.
Transition of Care for Children with High-Grade Central Nervous System Tumors
Authors: Ellenbogen Yosef , Yang Kaiyun , Ajani Olufemi 
Published: September 2020

AbstractThe increase in survival rates of children with high-grade central nervous system tumors has highlighted the necessity for and challenges associated with transition of care as these children grow into adult life. Late recurrence and treatment effects are some of the conditions that require care after transition. Several models of transition have been proposed in the literature. An effective transition will not only ensure adequate continuity of care but will also include assessment of effectiveness of the transition by health care personnel and the patient/patient's family themselves.
Silicon photonic transceivers for application in data centers
Authors: Wang Haomiao , Chai Hongyu , Lv Zunren , Zhang Zhongkai , Meng Lei , Yang Xiaoguang , Yang Tao 
Published: September 2020

Abstract
Global data traffic is growing rapidly, and the demand for optoelectronic transceivers applied in data centers (DCs) is also increasing correspondingly. In this review, we first briefly introduce the development of optoelectronics transceivers in DCs, as well as the advantages of silicon photonic chips fabricated by complementary metal oxide semiconductor process. We also summarize the research on the main components in silicon photonic transceivers. In particular, quantum dot lasers have shown great potential as light sources for silicon photonic integration—whether to adopt bonding method or monolithic integration—thanks to their unique advantages over the conventional quantum-well counterparts. Some of the solutions for high-speed optical interconnection in DCs are then discussed. Among them, wavelength division multiplexing and four-level pulse-amplitude modulation have been widely studied and applied. At present, the application of coherent optical communication technology has moved from the backbone network, to the metro network, and then to DCs.
Nanoflower ZnO thin-film grown by hydrothermal technique based Schottky diode
Authors: Ali Ghusoon M. , Khalid Ahmed K. , Swadi Salah M. 
Published: September 2020

Abstract
This paper reports the realization of planar Schottky diodes based on nanorod ZnO thin film. The nanorod ZnO thin film was fabricated by hydrothermal technique on boron doped p-type Si (100) substrate. The Ag//ZnO/Al planar diode operating with voltage bias from –3 to 3 V. The I–V characteristics clearly indicate that the devices have rectifying performance. The thermionic emission theory governs the current across the studied Schottky diode. The device achieved a turn-on voltage of 0.9 V, barrier height 0.69 eV and saturation current of 1.2 × 10–6 A. The diode shows a very large ideality factor (n > > 2) which is attributed to high interface trap concentration. The surface topology was investigated by scanning electron microscope (SEM). The structural properties of the nanostructured ZnO thin film were characterized by X-ray diffraction (XRD). The SEM images reveal that the ZnO nanorods grow perpendicular to the substrate with uniformity and high density. The XRD pattern illustrates the dominant peak appearing at (002). This intense peak indicates the c-axis orientated phase of the wurtzite ZnO structure. It demonstrates that the crystals grow uniformly perpendicular to the substrate surface in good agreement with the SEM images.
EEG-based detection of mental workload level and stress: the effect of variation in each state on classification of the other
Authors: Bagheri Mahsa , Power Sarah D 
Published: September 2020

Abstract

Objective. A passive brain-computer interface (pBCI) is a system that continuously adapts human-computer interaction to the user’s state. Key to the efficacy of such a system is the reliable estimation of the user’s state via neural signals, acquired through non-invasive methods like electroencephalography (EEG) or near-infrared spectroscopy (fNIRS). Many studies to date have explored the detection of mental workload in particular, usually for the purpose of improving safety in high risk work environments. In these studies, mental workload is generally modulated through the manipulation of task difficulty, and no other aspect of the user’s state is taken into account. In real-life scenarios, however, different aspects of the user’s state are likely to be changing simultaneously—for example, their cognitive state (e.g. level of mental workload) and affective state (e.g. level of stress/anxiety). This inevitable confounding of different states needs to be accounted for in the development of state detection algorithms in order for them to remain effective when taken outside the lab. Approach. In this study we focussed on two different states that are of particular importance in high risk work environments, specifically mental workload and stress, and explored the effect of each on the ability to detect the other using EEG signals. We developed an experimental protocol in which participants performed a cognitive task under two different levels of workload (low workload and high workload) and at two levels of stress (relaxed and stressed) and then used a linear discriminant classifier to perform classification of workload level and stress level independently. Main results. We found that the detection of both mental workload level (e.g. low workload vs. high workload) and stress level (e.g. stressed vs. relaxed) were significantly diminished if the training and test data came from different as opposed to the same level of the other state (e.g. for mental workload classification, training on data from a relaxed condition and testing on data from a stressed condition, rather than both training and testing on the relaxed condition). The reduction in classification accuracy observed was as much as 15%. Significance. The results of this study indicate the importance of considering multiple aspects of a user’s state when developing detection algorithms for pBCI technologies.
Diagnosis of major depressive disorder using whole-brain effective connectivity networks derived from resting-state functional MRI
Authors: Guo Man , Wang Tiancheng , Zhang Zhe , Chen Nan , Li Yongchao , Wang Yin , Yao Zhijun , Hu Bin 
Published: September 2020

Abstract

Objective. It is important to improve identification accuracy for possible early intervention of major depressive disorder (MDD). Recently, effective connectivity (EC), defined as the directed influence of spatially distant brain regions on each other, has been used to find the dysfunctional organization of brain networks in MDD. However, little is known about the ability of whole-brain resting-state EC features in identification of MDD. Here, we employed EC by whole-brain analysis to perform MDD diagnosis. Approach. In this study, we proposed a high-order EC network capturing high-level relationship among multiple brain regions to discriminate 57 patients with MDD from 60 normal controls (NC). In high-order EC networks and traditional low-order EC networks, we utilized the network properties and connection strength for classification. Meanwhile, the support vector machine (SVM) was employed for model training. Generalization of the results was supported by 10-fold cross-validation. Main results. The classification results showed that the high-order EC network performed better than the low-order EC network in diagnosing MDD, and the integration of these two networks yielded the best classification precision with 95% accuracy, 98.83% sensitivity, and 91% specificity. Furthermore, we found that the abnormal connections of high-order EC in MDD patients involved multiple widely concerned functional subnets, particularly the default mode network and the cerebellar network. Significance. The current study indicates whole-brain EC networks, measured by our high-order method, may be promising biomarkers for clinical diagnosis of MDD, and the complementary between high-order and low-order EC will better guide patients to get early interventions as well as treatments.
Single-layer Mo5Te8 ― A new polymorph of layered transition-metal chalcogenide
Authors: Zhang Junqiu , Xia Yipu , Wang Bo , Jin Yuanjun , Tian Hao , Ho Wing kin , Xu Hu , Jin Chuanhong , Xie Maohai 
Published: September 2020

Abstract
Single-layer (SL) transition-metal chalcogenides (TMCs) represent an important family of two-dimensional (2D) materials that have attracted intensive research attention recently. It has been established that many TMCs are polymorphic that can exist in different crystal structures and correspondingly exhibit diverse physical properties. Discovery of new structural phases of a crystal is of great scientific and practical importance. In this work, we report a new polymorph of SL-TMC, i.e. SL-Mo5Te8, attained by molecular-beam epitaxy (MBE). Like the 1H-MoTe2, it possesses the hexagonal symmetry but a much larger unit cell with a basis containing as many as 39 atoms (15 Mo and 24 Te). We call it the variational hexagonal (v1H) phase. Coincidently, it may be viewed also as one containing the highest density possible of mirror-twin domain boundaries (MTBs) in an otherwise pristine 1H-MoTe2. Electronically, it is metallic and a comparison between theory and experiments of its density-of-states (DOS) at the Fermi level reveals features pointing to an importance of electron interactions that invites further investigations.
An investigation into the possibility to eliminate the microstructural defects of parts printed using a Ni-rich Ni-Ti elemental powder mixture
Authors: Khanlari Khashayar , Shi Qi , Li Kefeng , Xu Ping , Cao Peng , Liu Xin 
Published: September 2020

Abstract
Ni-rich Ni-Ti alloys, such as 60NiTi, show a higher hardness and dimensional stability than equiatomic or near-equiatomic NiTinol ones. These make them suitable to be employed in structural applications. Laser powder bed fusion technique (LPBF) was used in this research to print parts from a Ni-rich Ni-Ti powder mixture consisting of about 63 wt.% Ni and 37 wt.% Ti. The microstructure of the obtained parts, processed using different parameters, showed inhomogeneity, contained undesirable Ni-rich and Ti-rich regions and a significant amount of cracks. To eliminate these defects, homogenize the microstructure and to obtain the required phases, we applied hot isostatic pressing (HIP) to the printed samples with a selected set of parameters. After HIP at 180 MPa and 1050 °C for 4 h, we observed the formation of a homogeneous microstructure containing mainly NiTi and Ni3Ti phases in the printed samples. However, cracks still persisted in the microstructure of these HIP treated samples. Applying another round of HIP treatment at a temperature just slightly above the melting start temperature of the samples, treated by the elementary HIP procedure, could successfully eliminate the cracks in the microstructure of samples and also increase the crystallinity of the existing phases.
Photoelectric effect on an Al/SiO2/p-Si Schottky diode structure
Authors: Saloma E , Alcántara S , Hernández-Como N , Villanueva-Cab J , Chavez M , Pérez-Luna G , Alvarado J 
Published: September 2020

Abstract
A SiO2 of 200 nm thickness layer was grown via thermal oxidation to obtain an Al/SiO2/p-Si MIS Schottky diode structure with top contacts and different active areas. Electrical measurements of MIS Schottky diode structure allow to observe the photoelectric effect only in the device with higher active area, as well as to obtain some electrical parameters such as the barrier height, the ideality factor and the density of interface states, which correspond to 0.97 eV, 1.46 and 4.44 × 1010 eV−1 cm−2 respectively. Furthermore, a fill factor of 0.202 and power conversion efficiency less than 1%. On the other hand, Capacitance-Voltage (C–V) measurements depict a positive and negative capacitance peaks at low frequencies; this behavior and photoelectric effect are attributed to the density of interface states at SiO2/p-Si, as well as to the Space-Charge-Limited Conduction process in the insulation layer. Furthermore, the use of this kind of insulator can allows increasing the conversion efficiency if it is used as bottom n-layer or front contact in tandem solar cells and silicon heterojunction solar cells, respectively.
What About Fluency? Implicit vs. Explicit Training Affects Artificial Mini-Language Production
Authors: Lichtman Karen 
Published: September 2020

AbstractA great deal of research explores how implicit vs. explicit instruction affects second language learners’ grammatical accuracy, generally finding that explicit instruction increases accuracy. However, no research to date has examined the impact of implicit/explicit instruction on learners’ fluency. Additionally, nearly all the research has only tested adult learners, despite strong claims about the effects of age on implicit vs. explicit language learning. This study tests the impact of implicit or explicit training on children’s and adults’ performance with an artificial mini-language. After seven days of training, fluency, accuracy, and explicit knowledge were measured. Implicit groups became significantly more fluent than explicit groups. Adults were more accurate than children, but training condition did not significantly affect accuracy. Adults and explicit groups developed more explicit knowledge than children and implicit groups, with no interactions between age and training condition. This study is one of the first to show measurable benefits for implicit second language instruction over explicit instruction: both children and adults produce sentences more fluently after implicit instruction.
A Screening Method for Cyanide in Blood by Dimethoxytriazinyl Derivatization-GC/MS
Authors: Yamaguchi Akinori , Miyaguchi Hajime 
Published: September 2020

Abstract
A simple screening analysis of cyanide in blood has been developed, using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM). DMTMM, a convenient reagent for dehydrocondensation, converted cyanide to 2-cyano-4,6-dimethoxy-1,3,5-triazine, the dimethoxytriazinyl derivative of cyanide. This reaction proceeded in whole blood samples after treatment with trichloroacetic acid, and in basic aqueous solution samples. Sufficient sensitivity was observed by the method using gas chromatography/mass spectrometry. Intra- and inter-day repeated analyses (0.05, 0.1, 0.25, 1 and 5 μg/mL, n = 5) were performed and the accuracy and precision were within 20% for the lower limit of quantification (LLOQ) and within 15% for other concentrations. LLOQs for the aqueous solution and blood were 0.05 and 0.1 μg/mL, respectively, which are suitable for detecting cyanide poisoning. The limits of detection (signal-to-noise ratio ≥ 3) for aqueous solution and blood were 0.01 and 0.05 μg/mL, respectively. Interference from 13 other anions was tested and no false positive response was obtained, even in the case of thiocyanate, nitrite and nitrate, which are known to yield cyanide by acid treatment of blood. This method is practical because it uses readily available reagents and equipment and is sensitive enough for the rapid screening of cyanide poisoning in forensic and clinical toxicology.