bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study
Authors: Kita Yoko , Watanabe Makoto , Kamon Daisuke , Ueda Tomoya , Soeda Tsunenari , Okayama Satoshi , Ishigami Kenichi , Kawata Hiroyuki , Horii Manabu , Inoue Fumitaka , Doi Naofumi , Okura Hiroyuki , Uemura Shiro , Saito Yoshihiko 
Published: August 2020

BACKGROUND
Vascular healing response associated with adjunctive n‐3 polyunsaturated fatty acid therapy therapy in patients receiving strong statin therapy remains unclear. The aim of this study was to evaluate the effect of polyunsaturated fatty acid therapy with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) in addition to strong statin therapy on coronary atherosclerotic plaques using optical coherence tomography.

METHODS AND RESULTS
This prospective multicenter randomized controlled trial included 130 patients with acute coronary syndrome treated with strong statins. They were assigned to either statin only (control group, n=42), statin+high‐dose EPA (1800 mg/day) (EPA group, n=40), statin+EPA (930 mg/day)+DHA (750 mg/day) (EPA+DHA group, n=48). Optical coherence tomography was performed at baseline and at the 8‐month follow‐up. The target for optical coherence tomography analysis was a nonculprit lesion with a lipid plaque. Between baseline and the 8‐month follow‐up, fibrous cap thickness (FCT) significantly increased in all 3 groups. There were no significant differences in the percent change for minimum FCT between the EPA or EPA+DHA group and the control group. In patients with FCT <120 µm (median value), the percent change for minimum FCT was significantly higher in the EPA or EPA+DHA group compared with the control group.

CONCLUSIONS
EPA or EPA+DHA therapy in addition to strong statin therapy did not significantly increase FCT in nonculprit plaques compared with strong statin therapy alone, but significantly increased FCT in patients with thinner FCT.

Registration

URL:
https://www.umin.ac.jp/ctr/
; Unique identifier: UMIN 000012825.
Orwell and Nineteen Eighty-Four Today: Genius and Tunnel Vision
Authors: Suvin Darko 
Published: August 2020

Abstract
Orwell, as he himself remarked, came from a lower, professional-service fraction of the English and imperial ruling class that was ‘simultaneously dominator and dominated’ (Raymond Williams), so that a combination of state and monopoly power became his abiding nightmare. His horizon was, as of the Spanish Civil War in 1936, a revolutionary socialism committed to freedom and equality, opposed both to Labourite social democracy and to Stalinist pseudo-communism. In this article, I concentrate on Nineteen Eighty-Four, drawing on narratology (its agential system, spacetime descriptions, and composition – ‘the Winston story’, the ‘Goldstein excerpts’, and the Appendix on Newspeak) and history. I conclude that Nineteen Eighty-Four has an interesting, but limited, ‘Tory anarchist’ stance and horizon: in revolt against the rulers, but not believing that the revolt can succeed (in direct polemic with the Communist Manifesto). In Orwell’s view there are ‘three kinds of people in the world, the High, the Middle and the Low’, but the mindless and passive Low reduce this to the Middle against the High, or intellect and impotence versus cynical power. ‘No economics’ entails here ‘no class struggle’, and a fair amount of misogyny. Orwell’s textural skill was penetrating, but his thematics very limited. Still, he was one of the first to notice the long-duration slide of politics toward fascism, even if he drew a mistaken consequence from it, as evident in his early conflation of Stalinism and Nazism into an untenable ‘totalitarianism’. Nineteen Eighty-Four remains a concerned, appealing, and in some ways useful text, albeit one that ultimately lacks wisdom.
Is There a Difference Between “Religion” and “Politics”?
Authors: Smith Leslie Dorrough 
Published: August 2020

Abstract
Scholars commonly compare and distinguish “religion” and “politics” in their analyses of certain social groups; they often do so in a way that presumes that such terms denote complicated yet still discrete realms that exist in varying degrees of interrelationship. Using the Christian Right as a case study, this essay proposes that we can draw from Bruce Lincoln and Oliver Freiberger’s insights regarding the methodological uses of comparison to reconsider how the terms “religion” and “politics” are deployed in our analyses. Rather than view these concepts as mirrors of some objective reality, scholars can create more robust critical perspectives if they treat these terms as insider products—that is, as flexible rhetorical categories modified by group insiders to achieve certain social effects.
The Desire for New Humanisms
Authors: Goodley Dan , Lawthom Rebecca , Liddiard Kirsty , Runswick-Cole Katherine 
Published: August 2020

Abstract
This paper articulates our desire for new humanisms in a contemporary cultural, economic and global context that has been described as posthuman. As researchers committed to modes of radical, critical, politicised and inclusive education, we are mindful of the significance of social theory and its relationship with articulations of social justice. Whilst sympathetic to the potentiality of posthuman thought we grapple with the imperative to embrace new humanisms that historicise and recognise global inequalities that concurrently exist in relation to a myriad of human categories including class, age, geopolitical location, gender, sexuality, race and disability. We focus in on the latter two categories and draw on ideas from postcolonial and critical disability studies. Our argument considers the problem of humanism (as a product of colonial Western imaginaries), the critical responses offered by posthuman thinking and then seeks to rearticulate forms of new humanism that are responsive to the posthuman condition and, crucially, the political interventions of Postcolonial and Critical Disability Scholars. We then outline six new humanist projects that could productively feed into the work of the Journal of Disability Studies in Education.
Evaluation of AIRS Cloud Phase Classification over the Arctic Ocean against Combined CloudSat–CALIPSO Observations
Authors: Peterson Colten A. , Yue Qing , Kahn Brian H. , Fetzer Eric , Huang Xianglei 
Published: August 2020

AbstractCloud phase retrievals from the Atmospheric Infrared Sounder (AIRS) are evaluated against combinedCloudSat–CALIPSO(CCL) observations using four years of data (2007–10) over the Arctic Ocean. AIRS cloud phase is evaluated over sea ice and open ocean separately using collocated CCL and AIRS fields of view (FOVs). In addition, AIRS and CCL cloud phase occurrences are evaluated seasonally, zonally, and with respect to total column water vapor (TCWV) and the temperature difference between 1000 and 300 hPa (ΔT1000−300). Last, collocated MODIS cloud information is implemented in a 1-month case study to assess the relationship between AIRS and CCL phase decisions, cloud cover, and cloud phase throughout the AIRS FOV. Depending on the surface type, AIRS classification skill for single-layer ice and liquid-phase clouds is over the ranges of 85%–95% and 22%–32%, respectively. Most unknown and liquid AIRS phase classifications correspond to mixed-phase clouds. AIRS ice-phase relative occurrence is biased low relative to CCL. However, the liquid-phase relative occurrence is similar between the two instruments. When compared with the CCL climatology, AIRS accurately represents the seasonal cycle of liquid and ice cloud phase across the Arctic as well as the relationship between cloud phase and TCWV and ΔT1000−300regime in some cases. The more heterogeneous the MODIS cloud macrophysical properties within an AIRS FOV are, the more likely it is that the AIRS FOV is classified as unknown phase.
The need for early referral to palliative care especially for Black, Asian and minority ethnic groups in a COVID-19 pandemic: Findings from a service evaluation
Authors: Chidiac Claude , Feuer David , Flatley Mary , Rodgerson Anna , Grayson Kate , Preston Nancy 
Published: August 2020

Background: Palliative care services face challenges in adapting and responding to the COVID-19 pandemic. Understanding how palliative care needs and outcomes have changed during the pandemic compared to before the pandemic is crucial to inform service planning and research initiatives. Aim: To evaluate the impact of COVID-19 on symptoms, clinical characteristics, and outcomes for patients referred to a hospital-based palliative care service in a district general hospital in London, UK. Design: A retrospective service evaluation. Data were extracted from the electronic patient records. Setting/participants: The first 60 inpatients with confirmed COVID-19 infection, referred to the hospital palliative care service between 1 March 2020 and 23 April 2020, and another 60 inpatients, referred to the hospital palliative care service between 11 March 2019 and 23 April 2019, were included from a district general hospital in East London, UK. Results: Patients with COVID-19 have lower comorbidity scores, poorer performance status, and a shorter time from referral to death compared to patients without COVID-19. Breathlessness, drowsiness, agitation, and fever are the most prevalent symptoms during COVID-19 compared to pain and drowsiness pre-COVID-19. Time from admission to referral to palliative care is longer for Black, Asian and minority ethnic patients, especially during COVID-19. Conclusion: Early referral to palliative care is essential in COVID-19, especially for Black, Asian and minority ethnic groups. There is urgent need to research why Black, Asian and minority ethnic patients are referred late; how palliative care services have changed; and possible solutions to setting up responsive, flexible, and integrated services.
Learning a palliative care approach during the COVID-19 pandemic: A case study in an Infectious Diseases Unit
Authors: Tanzi S , Alquati S , Martucci G , De Panfilis L 
Published: August 2020

Background: Hospital palliative care is an essential part of the COVID-19 response, but relevant data are lacking. The recent literature underscores the need to implement protocols for symptom control and the training of non-specialists by palliative care teams. Aim: The aim of the study was to describe a palliative care unit’s consultation and assistance intervention at the request of an Infectious Diseases Unit during the COVID-19 pandemic, determining what changes needed to be made in delivering palliative care. Design: This is a single holistic case study design using data triangulation, for example, audio recordings of team meetings and field notes. Setting/participants: This study was conducted in the Palliative Care Unit of the AUSL-IRCCS hospital of Reggio Emilia, which has no designated beds, consulting with the Infectious Diseases Unit of the same hospital. Results: A total of 9 physicians and 22 nurses of the Infectious Diseases Unit and two physicians of the Palliative Care Unit participated in the study. Our Palliative Care Unit developed a feasible 18-day multicomponent consultation intervention. Three macro themes were identified: (1) new answers to new needs, (2) symptom relief and decision-making process, and (3) educational and training issues. Conclusion: From the perspective of palliative care, some changes in usual care needed to be made. These included breaking bad news, patients’ use of communication devices, the limited time available for the delivery of care, managing death necessarily only inside the hospital, and relationships with families.
Incidence and Predictors of Subsequent Surgery After Anterior Cruciate Ligament Reconstruction: A 6-Year Follow-up Study
Authors:   MOON Knee Group, Sullivan Jaron P. , Huston Laura J. , Zajichek Alexander , Reinke Emily K. , Andrish Jack T. , Brophy Robert H. , Dunn Warren R. , Flanigan David C. , Kaeding Christopher C. , Marx Robert G. , Matava Matthew J. , McCarty Eric C. , Parker Richard D. , Vidal Armando F. , Wolf Brian R. , Wright Rick W. , Spindler Kurt P. 
Published: August 2020

Background: The cause of subsequent surgery after anterior cruciate ligament (ACL) reconstruction varies, but if risk factors for specific subsequent surgical procedures can be identified, we can better understand which patients are at greatest risk. Purpose: To report the incidence and types of subsequent surgery that occurred in a cohort of patients 6 years after their index ACL reconstruction and to identify which variables were associated with the incidence of patients undergoing subsequent surgery after their index ACL reconstruction. Study Design: Cohort study; Level of evidence, 2. Methods: Patients completed a questionnaire before their index ACL surgery and were followed up at 2 and 6 years. Patients were contacted to determine whether any underwent additional surgery since baseline. Operative reports were obtained, and all surgical procedures were categorized and recorded. Logistic regression models were constructed to predict which patient demographic and surgical variables were associated with the incidence of undergoing subsequent surgery after their index ACL reconstruction. Results: The cohort consisted of 3276 patients (56.3% male) with a median age of 23 years. A 6-year follow-up was obtained on 91.5% (2999/3276) with regard to information on the incidence and frequency of subsequent surgery. Overall, 20.4% (612/2999) of the cohort was documented to have undergone at least 1 subsequent surgery on the ipsilateral knee 6 years after their index ACL reconstruction. The most common subsequent surgical procedures were related to the meniscus (11.9%), revision ACL reconstruction (7.5%), loss of motion (7.8%), and articular cartilage (6.7%). Significant risk factors for incurring subsequent meniscus-related surgery were having a medial meniscal repair at the time of index surgery, reconstruction with a hamstring autograft or allograft, higher baseline Marx activity level, younger age, and cessation of smoking. Significant predictors of undergoing subsequent surgery involving articular cartilage were higher body mass index, higher Marx activity level, reconstruction with a hamstring autograft or allograft, meniscal repair at the time of index surgery, or a grade 3/4 articular cartilage abnormality classified at the time of index ACL reconstruction. Risk factors for incurring subsequent surgery for loss of motion were younger age, female sex, low baseline Knee injury and Osteoarthritis Outcome Score symptom subscore, and reconstruction with a soft tissue allograft. Conclusion: These findings can be used to identify patients who are at the greatest risk of incurring subsequent surgery after ACL reconstruction.
Importance of Retaining Sufficient Acetabular Depth: Successful 2-Year Outcomes of Hip Arthroscopy for Patients With Pincer Morphology as Compared With Matched Controls
Authors: Brick Claudia R. , Bacon Catherine J. , Brick Matthew J. 
Published: August 2020

Background: Patients with pincer-type femoroacetabular impingement are commonly treated with arthroscopic reduction of acetabular depth as measured by the lateral center-edge angle (LCEA). The optimal amount of rim reduction has not been established, although large resections may increase contact pressures through the hip. A recent publication demonstrated inferior surgical outcomes in patients with acetabular overcoverage as compared with normal acetabular coverage. Casual observation of our database suggested equivalent improvements, prompting a similar analysis. Purpose: To analyze patient-reported outcomes after hip arthroscopy for femoroacetabular impingement in patients with acetabular overcoverage who were matched with controls with normal coverage, as well as to analyze associations with reduction in LCEA. Study Design: Cohort study; Level of evidence, 3. Methods: Data were collected prospectively from patients with a minimum 2-year follow-up after receiving hip arthroscopy for femoroacetabular impingement by a single surgeon. Cases were reviewed to identify those with pincer-type morphology (LCEA >40°) and matched according to sex, age, chondral damage, and surgery date in a 1:1 ratio with controls with an LCEA of 25° to 40°. The surgical goal was to reduce the LCEA to the upper end of the normal range with minimal rim resection, usually 35° to 37°. Radiographic measurements of coverage, intraoperative findings, procedures, and patient-reported outcomes were recorded, including the 12-Item International Hip Outcome Tool, Non-arthritic Hip Score, Hip Disability and Osteoarthritis Outcome Score, visual analog scale for pain, rates of revision or reoperation, and conversion to total hip arthroplasty. Results: A total of 114 hips (93 patients) for the pincer group were matched 1:1 from 616 hips (541 patients) for the control group. The pincer group (mean ± SD age, 34.5 ± 12.2 years) did not differ in age, body mass index, or follow-up from controls. LCEA was reduced in both groups pre- to postoperatively: the pincer group from 44.0° ± 2.8° to 34.2° ± 3.5° and the controls from 32.9° ± 3.9° to 31.0° ± 3.0°. No differences in improvement were observed: iHOT-12 improved by 35.7 points in both groups ( P = .9 for analysis of variance interaction) and Nonarthritic Hip Score by 22.3 points ( P = .6). From all eligible surgical procedures, 2-year follow up rates were 2.5% and 2.6% for the pincer and control cohorts, respectively, and 1.2% and 0.3% for conversion to total hip arthroplasty. Conclusion: Arthroscopic management of acetabular overcoverage can achieve excellent results, equivalent to arthroscopy for other causes of symptomatic femoroacetabular impingement. A key finding was smaller rim resections producing a mean postoperative LCEA of 34.2° with a small standard deviation.
Surgical Repair of Distal Musculotendinous T Junction Injuries of the Biceps Femoris
Authors: Kayani Babar , Ayuob Atif , Begum Fahima , Singh Sandeep , Haddad Fares S. 
Published: August 2020

Background: Nonoperative management of injuries to the distal musculotendinous T junction of the biceps femoris is associated with variable periods of rehabilitation and high risk of recurrence. To our knowledge, the efficacy of operative treatment in patients with these acute injuries has not been previously reported. Hypothesis: Surgical repair of injuries to the distal musculotendinous T junction of the biceps femoris would enable return to preinjury level of sport with low risk of recurrence. Study Design: Case series; Level of evidence, 4. Methods: This prospective single-surgeon study included 34 professional athletes (mean age, 26.4 ± 3.1 years; 31 male [91.2%]; 3 female [8.8%]; body mass index, 25 ± 2.0 kg/m2) undergoing primary surgical repair of acute injuries to the distal musculotendinous T junction of the biceps femoris. All study patients underwent a standardized postoperative rehabilitation program. Predefined study outcomes relating to time for return to sporting activity, patient satisfaction, range of motion, hamstring muscle strength, passive range of motion, functional progress, and complications were recorded at regular intervals after surgery. Mean follow-up time was 28.4 months (range, 24.0-36.3 months) from date of surgery. Results: All study patients returned to their preinjury level of sporting activity. Mean time from surgical repair to full sporting activity was 11.7 ± 3.6 weeks. No patients had recurrence of the primary injury. At 1-year follow-up, 18 patients (52.9%) were very satisfied and 16 patients (47.1%) were satisfied with the outcomes of their surgery. At 3 months after surgery, patients had improved mean passive straight leg raise (69.7° ± 11.7° vs 24.1° ± 7.4°; P < .001); increased mean isometric hamstring muscle strength at 0° (93.1% ± 5.4% vs 63.1% ± 7.7%; P < .001), 45° (76.8% ± 9.7% vs 24.8% ± 8.3%; P < .001), and 90° (96.4% ± 3.9% vs 85.6% ± 5.9%; P < .001); higher mean lower extremity functional scores (64.5 ± 4.5 vs 27.2 ± 5.4; P < .001); and improved mean Marx Activity Rating Scale scores (10.7 ± 2.7 vs 2.2 ± 2.1; P < .001) compared with preoperative values. High patient satisfaction and functional outcome scores were maintained at 1 and 2 years after surgery. Conclusion: Surgical repair of acute injuries to the distal musculotendinous T junction of the biceps femoris is associated with high patient satisfaction, increased muscle strength, improved functional outcome scores, and high return to preinjury level of sporting activity with low risk of recurrence at short-term follow-up.
Allograft Donor Characteristics Significantly Influence Graft Rupture After Anterior Cruciate Ligament Reconstruction in a Young Active Population
Authors: Shumborski Sarah , Salmon Lucy J. , Monk Claire , Heath Emma , Roe Justin P. , Pinczewski Leo A. 
Published: August 2020

Background: Graft selection in anterior cruciate ligament (ACL) surgery can be difficult in a young active population given their high rates of reinjury. Allografts allow for control over graft size and reduce morbidity of autograft harvest. There are mixed results about the use of allograft in the literature; however, the influence of the properties of the allograft on outcomes has not been considered. Hypothesis: ACL reconstruction with allografts from older donors will have a higher rate of graft rupture when compared with allograft from young donors. Study Design: Cohort study; Level of evidence, 3. Methods: Patients (N = 211) aged 13 to 25 years underwent primary ACL reconstruction with fresh-frozen nonirradiated allograft. Four graft types were used: patellar tendon, Achilles tendon, tibialis anterior, and tibialis posterior. Details were collected on allograft donor age and sex. At a minimum of 24 months, patients were evaluated for any further injuries and subjective analysis by International Knee Documentation Committee (IKDC) questionnaire. Results: ACL graft rupture occurred in 23.5%. When grafts were separated into single strand (patellar and Achilles tendon) and multistrand (tibialis anterior and posterior), there was a significantly higher rate of reinjury in the single-strand grafts (29.9% vs 11%; P = .014). Grafts from female donors aged ≥50 years had significantly higher rates of ACL graft rupture (52.6%; P = .003) with increased odds by 6.7 times when compared with grafts from male donors aged <50 years. There was no significant difference in mean IKDC scores among the groups based on the age and sex of the allograft donor. Conclusion: The age and sex of the allograft donor and the morphology of the graft significantly influenced the rate of ACL graft rupture in young active patients. Tendons from female donors aged ≥50 years should be avoided given the higher rerupture rates as compared with male donors of any age and younger females.