bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease
Authors: Viola Helena M. , Shah Ashay A. , Johnstone Victoria P. A. , Cserne Szappanos Henrietta , Hodson Mark P. , Hool Livia C. 
Published: August 2020

Significance
Hypertrophic cardiomyopathy affects 1:500 of the general population. Current drug therapy is used to manage symptoms in patients. There is an unmet need for treatments that can prevent the cardiomyopathy. Here we identify biomarkers of hypertrophic cardiomyopathy resulting from causing cardiac troponin I mutation Gly203Ser, and present a safe, nontoxic, preventative approach for the treatment of associated cardiomyopathy.
Calibration of 1-D CMM artefacts: step gauges (EURAMET.L-K5.2016)
Authors: Coveney Tim , Matus Michael , Wang Shihua , Byman Ville , Lassila Antti , Alqahtani Nasser , Alqahtani Faisal , Sumner Dean , Spiller Jürg , Meli Felix , Picotto Gian Bartolo , Bellotti Roberto , Sato Osamu , Sharma Rina , Moona Girija , Kumar Vinod , Rodríguez Joaquín , Prieto Emilio , Meral İlker , Ganioğlu Okhan , Salgado José , Wójtowicz Adam , Skalník Pavel , Zelený Vít , Stoup John , Kotte Gerard , Koops Richard , Arizmendi Edgar , Wang Weinong , Jakobsson Agneta , Duta Alexandru , Dugheanu Elena , Reain Greg , Szikszai Gábor 
Published: August 2020

The results of the inter-RMO key comparison EURAMET.L-K5.2016 on the calibration of a step gauge are reported. Twenty-two National Metrology Institutes from four different metrological regions all over the world participated in this comparison which lasted three years, from December 2015 to December 2018.
Two artefacts were circulated so that the varying ranges of participants equipment could be accommodated. A 1020 mm ceramic monolithic step gauge remained stable throughout the comparison. A 610 mm steel step gauge changed length, possibly due to an impact while travelling between participants. The comparison of this artefact was divided into two groups, those before the damage and those after, with the reference value for each group derived from a linking participant who had demonstrated equivalence in the 1020 mm artefact circulation. For the 1020 mm comparison the inverse-variance weighted mean was taken as reference value.
Of the twenty two participants, eleven successfully demonstrated the validity of the claimed measurement capability. Of the remaining 11, 3 submitted revised uncertainties after the initial circulation of results which were shown to be valid when compared to the reference value. A set of recommendations and actions were agreed with the remaining participants.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Multiple dehydrogenation reactions of negative ions in low pressure silane plasma chemistry
Authors: Howling A A , Descoeudres A , Hollenstein Ch 
Published: August 2020

Abstract
Micro-particle formation in low pressure silane (SiH4) plasmas has been of technical interest and concern for at least 40 years. Negative ion plasma chemistry is a candidate for the initial nucleation, which has been extensively studied both experimentally and theoretically. Nevertheless, the nature and mechanisms of anion-neutral reactions remain uncertain in models of nucleation. In the pure silane, 0.1 mbar plasma of this work, silicon hydride anion mass spectra are interpreted in terms of iterative anion–silane reactions, involving release of one, or two, hydrogen molecules. Such ‘multiple dehydrogenation’ has been directly observed by Operti et al [2006 Rapid Commun. Mass Spectrom.
20 2696], where triple dehydrogenation also occurred. A statistical model, defined uniquely by a branching ratio of 68% for single hydrogenation, and 32% for double dehydrogenation, gives an accurate fit to the hydrogen distribution for all heavy silicon hydride anions (abbreviated here by ‘silanions’), up to at least 800 atomic mass units. Most theoretical models of silanion-neutral nucleation consider dehydrogenation where no more than one H2 molecule is released. It is suggested that multiple dehydrogenation could improve the comparison of theory with experiments.
The role of texturing and thickness of oxide buffer layers in the superconducting properties of Fe(Se,Te) Coated Conductors
Authors: Sylva G , Bellingeri E , Bernini C , Celentano G , Ferdeghini C , Leveratto A , Lisitskiy M , Malagoli A , Manca N , Mancini A , Manfrinetti P , Pallecchi I , Provino A , Putti M , Vannozzi A , Braccini V 
Published: August 2020

Abstract
In this paper the roles of texturing and thickness of different buffer layers employed in the fabrication of Fe(Se,Te) coated conductors are studied. Fe(Se,Te) thin films were deposited either on rolling assisted biaxially textured substrates substrates with highly textured CeO2 buffer layer and on HASTELLOY® C276 substrates with a randomly oriented native oxide grown through different oxidizing processes. It was found that the buffer layer has to be both thick enough to block Ni interdiffusion from the metallic tape to the Fe(Se,Te) overlayer, and textured enough to ensure good in-plane alignment of the superconducting film, and consequently good critical current densities (Jc). The best results in terms of critical temperature (Tc) and critical current were obtained using a highly textured 350 nm thick CeO2 buffer layer, but a fairly good Jc of 1.2 104 A cm−2 in self field at 5 K was also obtained using an HASTELLOY® C276 substrate with a 400 nm thick randomly oriented native oxide. The obtained results indicate that the superconducting properties of the Fe(Se,Te) coated conductors are determined by a trade-off between degree of texturing of the substrate and inhibition of Nickel interdiffusion.
Metamaterials designed for enhanced ENZ properties
Authors: Koivurova Matias , Hakala Tommi , Turunen Jari , Friberg Ari T , Ornigotti Marco , Caglayan Humeyra 
Published: August 2020

Abstract
We examine layered metamaterial structures consisting of alternating films of epsilon-near-zero (ENZ) and dielectric material, and show that for such a stack it is possible to enhance the refractive, reflective or absorptive properties of the ENZ. The proposed structure takes advantage of resonances from several interfaces, guided modes, and plasmon excitations to achieve the desired enhancement, and it is not an effective medium. We use analytical modeling tools to show how the different degrees of freedom affect the properties of the stack, and propose experimentally feasible parameters for such structures.
A review of estimating population exposure to sea-level rise and the relevance for migration
Authors: McMichael Celia , Dasgupta Shouro , Ayeb-Karlsson Sonja , Kelman Ilan 
Published: August 2020

Abstract
This review analyses global or near-global estimates of population exposure to sea-level rise (SLR) and related hazards, followed by critically examining subsequent estimates of population migration due to this exposure. Our review identified 33 publications that provide global or near-global estimates of population exposure to SLR and associated hazards. They fall into three main categories of exposure, based on definitions in the publications: (i) the population impacted by specified levels of SLR; (ii) the number of people living in floodplains that are subject to coastal flood events with a specific return period; and (iii) the population living in low-elevation coastal zones. Twenty of these 33 publications discuss connections between population migration and SLR. In our analysis of the exposure and migration data, we consider datasets, analytical methods, and the challenges of estimating exposure to SLR followed by potential human migration. We underscore the complex connections among SLR, exposure to its impacts, and migration. Human mobility to and from coastal areas is shaped by diverse socioeconomic, demographic, institutional, and political factors; there may be ‘trapped’ populations as well as those who prefer not to move for social, cultural, and political reasons; and migration can be delayed or forestalled through other adaptive measures. While global estimates of exposed and potentially migrating populations highlight the significant threats of SLR for populations living in low-lying areas at or near coastlines, further research is needed to understand the interactions among localised SLR and related hazards, social and political contexts, adaptation possibilities, and potential migration and (im)mobility decision-making.
Riemann surface for TASEP with periodic boundaries
Authors: Prolhac Sylvain 
Published: August 2020

Abstract
The Bethe ansatz solution of periodic TASEP is formulated in terms of a ramified covering from a Riemann surface to the sphere. The joint probability distribution of height fluctuations at n distinct times has in particular a relatively simple expression as a function of n variables on the Riemann surface built from exponentials of Abelian integrals, traced over the ramified covering and integrated on n nested contours in the complex plane.
A novel environment-friendly synthesis of high purity micron iron phosphate and its application as a precursor of lithium iron phosphate
Authors: Guo Ju , Mo Xinliang , Wu Fuyong , Yu Mei 
Published: August 2020

Abstract
This essay studies a novel environment-friendly synthesis method for the high purity micron iron phosphate. Compared with traditional synthesis method, this new method can greatly reduce the amount of industrial sewage, hence it is an environment-friendly production technology which can effectively improve the products’ purity, structure stability and morphological consistency. This new method includes two-step reactions: first, phosphoric acid, iron powder and hydrogen peroxide are used as raw materials to obtain iron phosphate dihydrate intermediate, which is then calcined at high temperature to obtain anhydrous iron phosphate. The results show that the iron phosphate prepared for this new method is a hexagonal system-structured iron orthophosphate with high purity and without any impurities, exhibiting a regular and primary spherical particle morphology, at the average size of 3.096μm in particle and the specific surface area reaching 39.1765 m2 g−1. With these excellent characteristics, it has better application potentials in the field of electrode material preparation. The electrochemical performance of lithium iron phosphate anode materials synthesized with it as the precursor is superior to those synthesized with the iron phosphate prepared by the traditional method as precursor. The first specific capacity of discharge at 0.5C and 10C can be as high as 154.3989 or 102.9326 mAh g−1, increasing by 2.74% and 8.03%, respectively.
Arbuscular mycorrhizal colonization outcompetes root hairs in maize under low phosphorus availability
Authors: Ma Xiaomin , Li Xuelian , Ludewig Uwe 
Published: August 2020

Abstract

Background and Aims
An increase in root hair length and density and the development of arbuscular mycorrhiza symbiosis are two alternative strategies of most plants to increase the root–soil surface area under phosphorus (P) deficiency. Across many plant species, root hair length and mycorrhization density are inversely correlated. Root architecture, rooting density and physiology also differ between species. This study aims to understand the relationship among root hairs, arbuscular mycorrhizal fungi (AMF) colonization, plant growth, P acquisition and mycorrhizal-specific Pi transporter gene expression in maize.

Methods
Using nearly isogenic maize lines, the B73 wild type and the rth3 root hairless mutant, we quantified the effect of root hairs and AMF infection in a calcareous soil under P deficiency through a combined analysis of morphological, physiological and molecular factors.

Key Results
Wild-type root hairs extended the rhizosphere for acid phosphatase activity by 0.5 mm compared with the rth3 hairless mutant, as measured by in situ zymography. Total root length of the wild type was longer than that of rth3 under P deficiency. Higher AMF colonization and mycorrhiza-induced phosphate transporter gene expression were identified in the mutant under P deficiency, but plant growth and P acquisition were similar between mutant and the wild type. The mycorrhizal dependency of maize was 33 % higher than the root hair dependency.

Conclusions
The results identified larger mycorrhizal dependency than root hair dependency under P deficiency in maize. Root hairs and AMF inoculation are two alternative ways to increase Pi acquisition under P deficiency, but these two strategies compete with each other.
Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice
Authors: Degiorgis Laetitia , Karatas Meltem , Sourty Marion , Faivre Emilie , Lamy Julien , Noblet Vincent , Bienert Thomas , Reisert Marco , von Elverfeldt Dominik , Buée Luc , Blum David , Boutillier Anne-Laurence , Armspach Jean-Paul , Blanc Frédéric , Harsan Laura-Adela 
Published: August 2020

AbstractIn Alzheimer’s disease, the tauopathy is known as a major mechanism responsible for the development of cognitive deficits. Early biomarkers of such affectations for diagnosis/stratification are crucial in Alzheimer’s disease research, and brain connectome studies increasingly show their potential establishing pathology fingerprints at the network level. In this context, we conducted an in vivo multimodal MRI study on young Thy-Tau22 transgenic mice expressing tauopathy, performing resting state functional MRI and structural brain imaging to identify early connectome signatures of the pathology, relating with histological and behavioural investigations. In the prodromal phase of tauopathy, before the emergence of cognitive impairments, Thy-Tau22 mice displayed selective modifications of brain functional connectivity involving three main centres: hippocampus (HIP), amygdala (AMG) and the isocortical areas, notably the somatosensory (SS) cortex. Each of these regions showed differential histopathological profiles. Disrupted ventral HIP-AMG functional pathway and altered dynamic functional connectivity were consistent with high pathological tau deposition and astrogliosis in both hippocampus and amygdala, and significant microglial reactivity in amygdalar nuclei. These patterns were concurrent with widespread functional hyperconnectivity of memory-related circuits of dorsal hippocampus—encompassing dorsal HIP-SS communication—in the absence of significant cortical histopathological markers. These findings suggest the coexistence of two intermingled mechanisms of response at the functional connectome level in the early phases of pathology: a maladaptive and a likely compensatory response. Captured in the connectivity patterns, such first responses to pathology could further be used in translational investigations as a lead towards an early biomarker of tauopathy as well as new targets for future treatments.
The 2008 Financial Crisis and the Lack of Retaliatory Trade Intervention
Authors: Li Chunding , Whalley John , He Chuantian , Lin Chuangwei 
Published: August 2020

Abstract
The 2008 financial crisis did not precipitate global retaliatory trade intervention, in seeming contrast to the Great Depression in 1930s. This article discusses the influence of model structure in optimal tariff (OT) calculations in explaining this puzzle. We emphasize how earlier literature reports high OTs in numerical calculation (of a hundred percent) but only uses simple trade models. We use numerical general equilibrium (GE) calibration and simulation methodology to calculate OTs both with and without retaliation in a series of observationally equivalent models and explore the influence of model structures on OT levels. We gradually add more realistic features into the basic GE model, and show sharply declined OTs, which suggests that trade retaliation incentives effectively disappear with the deepening of globalization in 2008 compared to 1930. (JEL codes: F11, C63, F13).
An implementation model for managing cloud-based longitudinal care plans for children with medical complexity
Authors: Wang Grace , Wignall Julia , Kinard Dylan , Singh Vidhi , Foster Carolyn , Adams Sherri , Pratt Wanda , Desai Arti D 
Published: August 2020

Abstract

Objective
We aimed to iteratively refine an implementation model for managing cloud-based longitudinal care plans (LCPs) for children with medical complexity (CMC).

Materials and Methods
We conducted iterative 1-on-1 design sessions with CMC caregivers (ie, parents/legal guardians) and providers between August 2017 and March 2019. During audio-recorded sessions, we asked participants to walk through role-specific scenarios of how they would create, review, and edit an LCP using a cloud-based prototype, which we concurrently developed. Between sessions, we reviewed audio recordings to identify strategies that would mitigate barriers that participants reported relating to 4 processes for managing LCPs: (1) taking ownership, (2) sharing, (3) reviewing, and (4) editing. Analysis informed iterative implementation model revisions.

Results
We conducted 30 design sessions, with 10 caregivers and 20 providers. Participants emphasized that cloud-based LCPs required a team of owners: the caregiver(s), a caregiver-designated clinician, and a care coordinator. Permission settings would need to include universal accessibility for emergency providers, team-level permission options, and some editing restrictions for caregivers. Notifications to review and edit the LCP should be sent to team members before and after clinic visits and after hospital encounters. Mitigating double documentation barriers would require alignment of data fields between the LCP and electronic health record to maximize interoperability.

Discussion
These findings provide a model for how we may leverage emerging Health Insurance Portability and Accountability Act–compliant cloud computing technologies to support families and providers in comanaging health information for CMC.

Conclusions
Utilizing these management strategies when implementing cloud-based LCPs has the potential to improve team-based care across settings.
Thiacloprid + Deltamethrin on the Life-Table Parameters of the Cotton Aphid, Aphis gossypii (Hemiptera: Aphididae), and the Parasitoid, Aphidius flaviventris (Hymenoptera: Aphelinidae)
Authors: Majidpour Marzieh , Maroofpour Nariman , Ghane-Jahromi Mojtaba , Guedes Raul Narciso C 
Published: August 2020

Abstract
A combination of pesticides and biological control agents is frequently necessary to achieve successful pest management requiring the assessment of their compatibility for the intended purpose. Aphidius flaviventris Kurdjumov is one of the parasitoids of the cotton aphid Aphis gossypii Glover, whose susceptibility to pesticides was not yet investigated. Accordingly, we investigated the lethal and sublethal effects of the commonly utilized insecticide mixture thiacloprid + deltamethrin on the cotton aphid and its parasitoid wasp Aphidius flaviventris. The estimated LC50 for the aphid was 14.1 mg ai/l; the effects of sublethal exposure at LC10 (2.80 mg ai/l) and LC30 (7.28 mg ai/l) on the aphid life-table parameters led to significantly increase on the development time of third- and fourth-instar nymphs and preadult. Sublethal exposure to the insecticide mixture compromised aphid longevity, fecundity, and life-table parameters (r, R0, and T). Moreover, population growth and parasitism rate of the parasitoid were significantly compromised at both concentrations of the insecticide mixture under sublethal exposure. These results not only indicate the efficacy of thiacloprid + deltamethrin against the cotton aphid, but also raise concerns regarding its negative impacts on the parasitoid Aphidius flaviventris and caution against its use in pest management programs.
Host Overwintering Phenology and Climate Change Influence the Establishment of Tetrastichus planipennisi Yang (Hymenoptera: Eulophidae), a Larval Parasitoid Introduced for Biocontrol of the Emerald Ash Borer
Authors: Gould Juli R , Warden Melissa L , Slager Benjamin H , Murphy Theresa C 
Published: August 2020

Abstract
Emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), is one of the most serious forest pests in the United States. Ongoing research indicates that establishment of larval parasitoids depends upon the season-long availability of host stages susceptible to parasitism. We monitored emerald ash borer overwintering stages at 90 sites across 22 states to: 1) produce a model of the percentage of emerald ash borer overwintering as non-J larvae; 2) link that model to establishment of Tetrastichus planipennisi; and 3) explore changes to our model under climate change scenarios. Accumulated growing degree days (GDD) is an important predictor of the proportion of emerald ash borer overwintering as non-J larvae (1–4 instar larvae under the bark; available to parasitoids emerging in spring) versus J-larvae (fourth-instar larvae in pupal chambers in the outer wood; unavailable to parasitoids). From north to south, the availability of non-J emerald ash borer larvae in the spring decreases as accumulated GDD increases. In areas where the model predicted &gt;46–75%, &gt;30–46%, &gt;13–30%, or ≤13% of emerald ash borer overwintering as non-J larvae, the probability of establishment of T. planipennisi was 92%, 67%, 57%, and 21%, respectively. We determined that 13% of emerald ash borer overwintering as non-J larvae was the lowest threshold for expected T. planipennisi establishment. Additional modeling predicts that under climate change, establishment of T. planipennisi will be most affected in the Central United States, with areas that are currently suitable becoming unsuitable. Our results provide a useful tool for the emerald ash borer biological control program on how to economically and successfully deploy emerald ash borer biological control agents.
Improving the Phenotypic Properties of the Ceratitis capitata (Diptera: Tephritidae) Temperature-Sensitive Lethal Genetic Sexing Strain in Support of Sterile Insect Technique Applications
Authors: Porras Mitzy F , Meza Jose S , Rajotte Edwin G , Bourtzis Kostas , Cáceres Carlos 
Published: August 2020

Abstract
The genetic sexing strain (GSS) of the Mediterranean fruit fly (Ceratitis capitata (Wiedemann)) Vienna 8D53− is based on a male-linked translocation system and uses two selectable markers for male-only production, the white pupae (wp) and the temperature sensitivity lethal (tsl) genes. In this GSS, males emerge from brown pupae and are resistant to high temperatures while females emerge from white pupae, are sensitive to high temperatures. However, double homozygous females (wp tsl/wp tsl) exhibit a slower development rate compared to heterozygous males (wp+tsl+/wp tsl) during the larval stage, which was attributed to the pleiotropic effects of the tsl gene. We present the first evidence that this slower development is due to a different gene, here namely slow development (sd), which is closely linked to the tsl gene. Taking advantage of recombination phenomena between the two loci, we report the isolation of a novel temperature sensitivity lethal strain using the wp mutation as a morphological marker, which showed faster development (wp tsl FD) during the larval stage and increased in its temperature sensitivity compared with the normal tsl strain. Moreover, the introgression of this novel wp tsl FD combined trait into the Vienna 8D53− GSS, resulted in a novel Vienna 8D53− FD GSS, where females showed differences in the thermal sensibility, larval development speed, and productivity profiles. The modification of these traits and their impact on the mass rearing of the GSS for sterile insect technique applications are discussed.