bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmc overexpression enhances malignancies in human colon cancer
Authors: Gao Tianbo , Du Tan , Hu Xin , Dong Xichen , Li Lina , Wang Yakun , Liu Jian , Liu Lijie , Gu Tao , Wen Tao 
Published: October 2019

AbstractCosmc is known as a T‐synthase‐specific molecular chaperone that plays a crucial role in the process of O‐glycosylation. Cosmc dysfunction leads to inactive T‐synthase and results in aberrant O‐glycosylation, which is associated with various tumour malignancies. However, it is unclear whether Cosmc has some other functions beyond its involvement in O‐glycosylation. In this study, we aimed to investigate the functional role of Cosmc in human colorectal cancer (CRC). We first assessed the expression levels of Cosmc in human CRC specimens and then forcedly expressed Cosmc in human CRC cell lines (HCT116, SW480) to examine its impact on cellular behaviours. The mechanisms for aberrant expression of Cosmc in CRC tissues and the altered behaviours of tumour cells were explored. It showed that the mRNA and protein levels of Cosmc were markedly elevated in human CRC specimens relative to normal colorectal tissues. The occurrence of endoplasmic reticulum (ER) stress may largely contribute to the increased Cosmc expression in cancer tissue and cells. Cosmc overexpression in CRC cells significantly promoted cell migration and invasion, which could be attributed to the activation of the epithelial‐mesenchymal transition (EMT) pathway rather than aberrant O‐glycosylation. These data indicate that Cosmc expression was elevated in human CRC possibly caused by ER stress, which further enhanced malignancies through the activation of EMT but independently of aberrant O‐glycosylation.
Dyslexia and Developmental Language Disorder: comorbid disorders with distinct effects on reading comprehension
Authors: Snowling Margaret J. , Hayiou‐Thomas Marianna E. , Nash Hannah M. , Hulme Charles 
Published: October 2019

BackgroundReading comprehension draws on both decoding and linguistic comprehension, and poor reading comprehension can be the consequence of a deficit in either of these skills.MethodsUsing outcome data from the longitudinal Wellcome Language and Reading Project, we identified three groups of children at age 8 years: children with dyslexia (N = 21) who had deficits in decoding but not oral language, children with Developmental Language Disorder (DLD; N = 38) whose decoding skills were in the normal range, and children who met criteria for both dyslexia and DLD (N = 29).ResultsAll three groups had reading comprehension difficulties at the ages of 8 and 9 years relative to TD controls though those of the children with dyslexia were mild (relative to TD controls, d = 0.51 at age 8, d = 0.60 at age 8); while the most severe problems were found in the comorbid dyslexia + DLD group (d = 1.79 at age 8, d = 2.06 at age 9) those with DLD also had significant difficulties (d = 1.56 at age 8, d = 1.56 at age 9).ConclusionsThese findings confirm that children with dyslexia or DLD are at‐risk for reading comprehension difficulties but for different reasons, because of weak decoding in the case of dyslexia or weak oral language skills in the case of DLD. Different forms of intervention are required for these groups of children, targeted to their particular area(s) of weakness.
Life cycle assessment of emerging environmental technologies in the early stage of development: A case study on nanostructured materials
Authors: Bartolozzi Irene , Daddi Tiberio , Punta Carlo , Fiorati Andrea , Iraldo Fabio 
Published: October 2019

AbstractThe use of nanostructured materials has been recently proposed in the field of environmental nanoremediation. This approach consists in using nanomaterials not directly, but as building blocks for the design of nano‐porous micro‐dimensional systems, overcoming the eco‐ and health‐toxicology risks generally associated with the use of nano‐sized technologies. Herein we report the use of life cycle assessment (LCA) as an eco‐design tool for optimizing the production of cellulose nanosponges (CNS), nanostructured materials recently developed for water remediation purposes. LCA was applied from the acquisition of raw materials to the synthesis of CNS (from cradle‐to‐gate), considering three production systems, from the lab‐level to a modeled scale‐up system. The lab‐scale LCA identified the main environmental hotspots, namely the energy‐consuming steps and the final purification of the material (washing step). In a second lab‐scale production, an improvement action could be implemented, switching the washing solvent from methanol to water and decreasing the washing temperature. A second LCA showed a reduced contribution to the impacts from the materials, while the global impacts remained within the same order of magnitude. A simulated scale‐up of the process allowed to optimize the energy‐consuming steps and the water consumption, through internal recycling. A third LCA assessed the resulting benefits and a decrease in the global impacts by two orders of magnitude. Our study contributes to the discussion of LCA community, providing a focus on the importance of scaling‐up of emerging technologies, namely nanostructured porous materials, highlighting the benefits of a LCA based approach since the very beginning of product design (eco‐design).
“I love being a midwife; it's who I am”: A Glaserian Grounded Theory Study of why midwives stay in midwifery
Authors: Bloxsome Dianne , Bayes Sara , Ireson Deborah 
Published: October 2019

AbstractAims and objectivesTo understand why Western Australian (WA) midwives choose to remain in the profession.BackgroundMidwifery shortages and the inability to retain midwives in the midwifery profession is a global problem. The need for effective midwifery staff retention strategies to be implemented is therefore urgent, as is the need for evidence to inform those strategies.DesignGlaserian grounded theory (GT) methodology was used with constant comparative analysis.MethodsFourteen midwives currently working clinically area were interviewed about why they remain in the profession. The GT process of constant comparative analysis resulted in an overarching core category emerging. The study is reported in accordance with Tong and associates’ (2007) Consolidated Criteria for Reporting Qualitative Research (COREQ).ResultsThe core category derived from the data was labelled—“I love being a midwife; it's who I am.” The three major categories that underpin the core category are labelled as follows: “The people I work with make all the difference”; “I want to be ‘with woman’ so I can make a difference”; and “I feel a responsibility to pass on my skills, knowledge and wisdom to the next generation.”ConclusionIt emerged from the data that midwives’ ability to be “with woman” and the difference they feel they make to them, the people they work with and the opportunity to “grow” the next generation together underpin a compelling new middle‐range theory of the phenomenon of interest.Relevance to clinical practiceThe theory that emerged and the insights it provides will be of interest to healthcare leaders, who may wish to use it to help develop midwifery workforce policy and practice, and by extension to optimise midwives’ job satisfaction, and facilitate the retention of midwives both locally and across Australia.
Panel performance, discrimination power of descriptors, and sensory characterization of table olive samples
Authors: Lanza Barbara , Amoruso Filomena 
Published: October 2019

AbstractThe COI/OT/MO No. 1/Rev. 2—November 2011 method establishes the necessary criteria and procedure for the sensory analysis of table olives by a group of 8–10 expert/selected tasters and a panel leader. The performance of each individual taster and the whole panel was monitored on a regular basis, involving the analysis of replicated samples and retraining of tasters with references. Univariate and multivariate (two‐way analysis of variance, Line plot, Eggshell plot, PCA, Tucker‐1 plot) statistical techniques by the open‐source software PanelCheck V 1.4.2—2015 were applied. From the analysis of the data, hardness is quite highlighted for all assessors indicating that the panel agrees well for this characteristic, while for remaining attributes (salty, bitter, acid, fibrousness, and crunchiness) the situation is more complex and was analyzed case by case.Practical ApplicationsIn this study, assessors having good discrimination ability and repeatability were identified, and in the same time we acquired information regarding the difficulty to recognize/evaluate some attributes. These results were also used to investigate on the discrimination power of the descriptors.
MgAl2O4 spinels from Allende and NWA 763 carbonaceous chondrites: Structural refinement, cooling history, and trace element contents
Authors: Lenaz Davide , Lughi Vanni , Perugini Diego , Petrelli Maurizio , Turco Gianluca , Schmitz Birger 
Published: October 2019

AbstractMgAl2O4 spinels from Allende and NWA 763 carbonaceous chondrites were studied by X‐ray single crystal diffraction, SEM, electron microprobe, LA‐ICP‐MS, and Raman spectroscopy. Those from Allende are almost pure, but, in one case, we found a strong FeOtot zonation. Spinels from NWA 763 show Mg‐Fe2+ substitutions. Almost pure MgAl2O4 spinels from both meteorites underwent slow cooling and reached their intracrystalline closure temperature (Tc) in the range 460–520 °C. The NWA 763 spinel with higher FeO content shows a Tc of about 720 °C. X‐ray single crystal diffraction and Raman spectroscopy suggest a slow cooling and an ordered structure with trivalent cations in M site and divalent in T site. Among the trace elements, Ti and Co are enriched with respect to the terrestrial analogs, while Mn, Ni, and Sn show intermediate values between different terrestrial occurrences. Vanadium cannot be used as a tracer of extraterrestrial origin as for Cr‐spinels, because its content is similar in extraterrestrial and terrestrial spinels. In the zoned crystal from Allende, Co show a strong zonation similar to that of FeO.
Bartleby's remains
Authors: Stables Wayne 
Published: October 2019

AbstractTaking issue with those readings of Melville's tale that are caught between the need to account for Bartleby and the need to account for the impossibility of the account, this article draws attention to the diverse ways in which ‘Bartleby, the Scrivener’ harbours a theory of transmission which troubles the function and promise of theory as such. It revisits some of the most influential interpretations of the text before turning to Foucault's ‘Thought of the outside’ and Derrida's late essay, ‘A certain impossible possibility of saying the event’. The nub of the argument is that in the current critical climate, which often seems bent on effecting the most economic relation between textual phenomena and normative orders of historical, cultural or social significance, the most pressing injunction is less to render Bartleby, or his famous ‘formula’, readable than to show how Melville's text preserves the radical originality of an event, giving us to think that which precedes every measure of equivalence and exceeds the equilibrium of exchange: what remains of language when it has been purged of sense.
Use of self‐adherent silicone sheets in a pediatric burn patient: A case report and instructions for use
Authors: Eisendle Klaus , Pichler Maria , De Luca Jenny , Thuile Tobias 
Published: October 2019

AbstractBurns and scalds are relatively common injuries in children. Formation of hypertrophic scars or keloids is feared complications. A 2‐year‐old girl who spilled a cup of hot coffee onto herself developed widespread hypertrophic scars and beginning keloids on her upper chest, despite application of pressure garments and daily massage with silicone gel. Herein, we describe instructions for use of prolonged continuous 24‐hour occlusive application of self‐adherent silicone sheets to help mitigate the formation of scar tissue.
Monozygotic twins with atrophia maculosa varioliformis cutis
Authors: Agrawal Sandip , Sharma Aseem , Dhurat Rachita , Ghate Smita , Sharma Richa 
Published: October 2019

AbstractAtrophia maculosa varioliformis cutis (AMVC) is a sporadic or inherited childhood disorder, signified by the occurrence of pitted scars, usually over the face. We report two cases of AMVC occurring in monozygotic twins.
Outbreak of freckle disease (Phyllosticta cavendishii) on Cavendish bananas in Australia and the initial biosecurity response
Authors: McMaster C. A. , Tran‐Nguyen L. T. T. , Voutsinos M. Y. , Cook S. E. , Condé B. D. , West S. J. , Nguyen T. V. , Liberato J. R. 
Published: October 2019

Phyllosticta cavendishii has been recorded in the Northern Territory (NT) of Australia occurring on non‐Cavendish bananas since 1991. The race of P. cavendishii that infects Cavendish bananas is considered exotic to Australia and classified as an emergency plant pest. In July 2013, P. cavendishii was detected on Cavendish bananas near Darwin, NT. Here, the diagnoses and field observations carried out during the Incident Definition Phase of the national biosecurity response, from July 2013 to October 2014, are reported. Of 1395 banana samples collected from 676 properties, 480 were positive for freckle disease, including 463 samples with P. cavendishii and 17 samples with P. maculata. Phyllosticta cavendishii was detected in 256 properties, including 62 properties where it was detected on Cavendish banana plants, within six distinct geographical zones across the NT. Phyllosticta cavendishii was detected on two cultivars within the Cavendish subgroup and six non‐Cavendish cultivars. Multigene characterization of Phyllosticta cultures showed that P. cavendishii was isolated from both Cavendish and non‐Cavendish cultivars. Multilocus phylogeny analyses also revealed that the P. cavendishii strain in the outbreak had identical sequence similarity to the holotype (CBS H‐20918) clade 2 P. cavendishii isolates that infect both Cavendish and non‐Cavendish cultivars in Southeast Asia and Oceania. The genetic data in this study showed that there was one P. cavendishii strain infecting both Cavendish and non‐Cavendish cultivars in the outbreak. However, historical data and field observations provided anecdotal evidence for the existence of two races of P. cavendishii, including one that does not infect Cavendish bananas.
Low‐density lipoproteins and milk serum proteins improve the quality of stallion sperm after vitrification in straws
Authors: Consuegra Cesar , Crespo Francisco , Dorado Jesús , Diaz‐Jimenez Maria , Pereira Blasa , Hidalgo Manuel 
Published: October 2019

AbstractLipids and proteins can be used for sperm vitrification to preserve the integrity of sperm membranes or to increase the viscosity of the medium. This study evaluated the effect of low‐density lipoproteins (LDL) and milk serum proteins (Pronexcell) for stallion sperm vitrification. Hippex extender (Barex Biochemical Products, The Netherlands), plus 1% of bovine serum albumin and 100 mM of trehalose, was used as control for sperm vitrification. In experiment 1, different concentrations of LDL (L1 = 0.25, L2 = 0.5, L3 = 1%) and in experiment 2 of Pronexcell (P1 = 1, P2 = 5, P3 = 10%) were added to control extender. Vitrification was performed in 0.25‐ml straws directly plunged into liquid nitrogen. Total motility (TM, %) and progressive motility (PM, %) were analysed by CASA, and plasma membrane (IMS, %) and acrosome membrane integrity (AIS, %) were assessed under epifluorescence microscopy. Post‐warmed sperm parameters were compared between treatments by ANOVA. Results were expressed as mean ± SEM. In both experiments, the minimum concentration of LDL and Pronexcell obtained significantly higher values (p < 0.01) than the control extender for TM (L1 = 52.95 ± 4.4; P1 = 58.99 ± 4.6; C = 30.88 ± 3.0), PM (L1 = 36.79 ± 5.5; P1 = 47.25 ± 4.3; C = 19.20 ± 2.4), IMS (L1 = 68.88 ± 3.6; P1 = 47.25 ± 4.3; C = 52.81 ± 2.6) and AIS (L1 = 45.88 ± 3.6; P1 = 47.25 ± 4.3; C = 26.00 ± 2.1). No differences in sperm parameters were found among different concentrations of LDL or Pronexcell. In conclusion, the addition of 0.25% LDL and 1% Pronexcell to the vitrification extender is recommended to improve the quality of stallion sperm after vitrification.
Relationship between DNA fragmentation of equine granulosa cells and oocyte meiotic competence after in vitro maturation
Authors: Pereira Blasa , Dorado Jesús , Diaz‐Jimenez Maria , Consuegra Cesar , Ortiz Isabel , Gosalvez Jaime , Hidalgo Manuel 
Published: October 2019

AbstractThe acquisition of equine oocyte developmental capacity is ensured by the follicular environment, such as granulosa cells, which could reflect the meiotic development potential of immature oocytes. This study evaluated the relationship between DNA fragmentation of granulosa cells, using the chromatin dispersion test, and equine oocyte meiotic development after in vitro maturation. Granulosa cells and cumulus–oocytes complexes (n = 50) were recovered from slaughterhouse‐derived ovaries. Oocytes were in vitro matured, stained and evaluated under fluorescence microscopy. Maturation rates were classified into outstanding, medium and poor levels of maturation using 25th and 75th percentiles as thresholds. For DNA assessment, each sample was processed with the Ovoselect® kit (Halotech DNA). High, low and total DNA fragmentation percentages were compared among levels of maturation rates by ANOVA, followed by Duncan test. Results were expressed as mean ± SE. Total and high DNA fragmentation rates of granulosa cells were significantly higher (p < 0.05) in follicles whose oocytes had reached outstanding maturation level than those originating from follicles whose oocytes had reached poor maturation level. In conclusion, the DNA fragmentation analysis of equine granulosa cells can be a valuable test to identify equine oocytes showing the best meiotic competence after in vitro maturation.
Bayesian Empirical Likelihood Inference with Complex Survey Data
Authors: Zhao Puying , Ghosh Malay , Rao J. N. K. , Wu Changbao 
Published: October 2019

SummaryWe propose a Bayesian empirical likelihood approach to survey data analysis on a vector of finite population parameters defined through estimating equations. Our method allows overidentified estimating equation systems and is applicable to both smooth and non-differentiable estimating functions. Our proposed Bayesian estimator is design consistent for general sampling designs and the Bayesian credible intervals are calibrated in the sense of having asymptotically valid design-based frequentist properties under single-stage unequal probability sampling designs with small sampling fractions. Large sample properties of the Bayesian inference proposed are established for both non-informative and informative priors under the design-based framework. We also propose a Bayesian model selection procedure with complex survey data and show that it works for general sampling designs. An efficient Markov chain Monte Carlo procedure is described for the required computation of the posterior distribution for general vector parameters. Simulation studies and an application to a real survey data set are included to examine the finite sample performances of the methods proposed as well as the effect of different types of prior and different types of sampling design.
Late Cambrian microbial build‐ups, Llano Area, Central Texas: A three‐phase morphological evolution
Authors: Khanna Pankaj , Hopson Heath H. , Droxler André W. , Droxler Dylan A. , Lehrmann Daniel , Kubik Brian , Proctor Jacob , Singh Pulkit , (Mitch) Harris Paul M. 
Published: October 2019

AbstractAlthough Late Cambrian microbial build‐ups were recognized in the Point Peak Member of the Wilberns Formation in Central Texas (USA) nearly 70 years ago, only a few studies focused specifically on the build‐ups themselves. This study focuses on the interpretation of the regional (15 measured sections described in literature representing an area of 8000 km2) and local (field and drone photogrammetry studies in a 25 km2 area from within south Mason County) microbial build‐up occurrence, describes their growth phases and details their interactions with the surrounding inter‐build‐up sediments. The study establishes the occurrence of microbial build‐ups in the lower and upper Point Peak members (the Point Peak Member is informally broken up into the lower Point Peak and the upper Point Peak members separated by Plectotrophia zone). The lower Point Peak Member consists of three <1 m thick microbial bioherms and biostrome units, in addition to heterolithic and skeletal/ooid grainstone and packstone beds. One, up to 14 m thick, microbial unit associated with inter‐build‐up skeletal and ooid grainstone and packstone beds, intercalated with mixed siliciclastic–carbonate silt beds, characterizes the upper Point Peak member. The microbial unit in the upper Point Peak member displays a three‐phase growth evolution, from an initial colonization phase on flat based, rip‐up clast lenses, to a second aggradation and lateral expansion phase, into a third well‐defined capping phase. The ultimate demise of the microbial build‐ups is interpreted to have been triggered by an increase of water turbidity caused by a sudden influx of fine siliciclastics. The lower Point Peak member represents inner ramp shallow subtidal and intertidal facies and the upper Point Peak member corresponds to mid‐outer ramp subtidal facies. Understanding the morphological architecture and depositional context of these features is of importance for identifying signatures of early life on Earth.
Transfusion of red blood cells does not impact progression‐free and overall survival after surgery for ovarian cancer
Authors: Hunsicker Oliver , Gericke Sara , Graw Jan Adriaan , Krannich Alexander , Boemke Willehad , Meyer Oliver , Braicu Ioana , Spies Claudia , Sehouli Jalid , Pruß Axel , Feldheiser Aarne 
Published: October 2019

BACKGROUNDAllogeneic red blood cells (RBCs) have the potential to impact the immunosurveillance of the recipient and may therefore increase the risk of recurrence after cancer surgery. In this article the relationship between perioperative RBC transfusion and the risk of recurrence after ovarian cancer surgery is examined.STUDY DESIGN AND METHODSThis is a retrospective cohort analysis of a prospective database of patients who underwent surgery due to primary ovarian cancer between 2006 and 2014 and who had no residual disease after surgery. Patients who did and did not receive perioperative RBC transfusion were compared. The primary endpoint was progression‐free survival (PFS). Propensity score matching (PSM) and Cox proportional hazards regression (CPH) was used to control for between‐group differences of prognostic determinants.RESULTSA total of 529 patients with a median follow‐up of 51.4 months (95% CI, 46.1‐56.5) were eligible for analysis. Of those, 408 patients (77.1%) received allogeneic, leukoreduced RBCs with a median of 4 units (IQR, 2‐6) per patient. There was a strong selection bias of prognostic determinants between patients with and without transfusion. In unadjusted analysis, transfusion of RBCs was associated with an increased risk of cancer recurrence (hazard ratio [HR] of PFS 2.71 [95% CI, 1.94‐3.77], p < 0.001). After bias reduction, transfusion of RBCs was no longer associated with an increased risk of cancer recurrence, neither in PSM‐adjusted (HR 1.03 [95% CI, 0.59‐1.80], p = 0.91), nor in multivariable CPH‐adjusted analysis (HR 1.26 [95% CI, 0.85‐1.86], p = 0.23).CONCLUSIONPerioperative transfusion of RBCs did not increase the risk of recurrence after ovarian cancer surgery.