bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report
Authors: Grondin Anthony , Baudou Eloïse , Pasquet Marlène , Pelluau Sonia , Jamal-Bey Karim , Bermot Cécile , Villega Frederic , Cheuret Emmanuel 
Published: December 2019

AbstractSeventeen-day-old twins were hospitalized for neonatal herpes simplex virus 1 (HSV-1) with central nervous system disease and internal capsule and thalamic lesions on magnetic resonance imaging (MRI). They were treated with the usual intravenous (IV) treatment and oral therapy for 6 months. The clinical course was good in both children with negative HSV polymerase chain reaction on completion of IV therapy. The neurological condition recurred in one child with new radiological lesions at 7 months of age, 2 weeks after discontinuation of oral treatment. Cerebral lesions highlighted on the MRI scan are specific to the neonatal period and impact long-term prognosis. The likely genetic predisposition in this case is interesting and requires further investigation. In addition, this case raises questions about the duration of oral acyclovir suppressive therapy.
Aging and the Biological Response to Liver Injury
Authors: Marzioni Marco , Pinto Claudio , Ninfole Elisabetta , Gaggiano Laura , Benedetti Antonio , Maroni Luca 
Published: December 2019

AbstractInterest in understanding the aging process has recently risen in the scientific community. Aging, commonly defined as the functional decline in the function of organs and tissues, is indeed the major risk factor for the development of many chronic diseases, such as cardiovascular diseases, pathologies of nervous system, or cancer. To date, the influence of aging in the pathophysiology of liver and biliary diseases is not fully understood. Although liver cells have a high regenerative capacity, hepatocytes and cholangiocytes undergo extensive molecular changes in response to aging. Following time-dependent damage induced by aging, liver cells initially activate compensatory mechanisms that, if hyperstimulated, may lead to the decline of regenerative capacity and the development of pathologies. A deeper understanding of molecular aging has undoubtedly the potential to improve the clinical management of patients, possibly unveiling new pathways for selective drug treatment.
Radiographic Comparison of the Mechanical Axis Including Calcaneus to the Conventional Mechanical Axis in Medial Unicompartmental Knee Arthroplasty
Authors: Kuroda Yuichi , Takayama Koji , Ishida Kazunari , Hayashi Shinya , Hashimoto Shingo , Tsubosaka Masanori , Kamenaga Tomoyuki , Matsushita Takehiko , Niikura Takahiro , Kuroda Ryosuke , Matsumoto Tomoyuki 
Published: December 2019

AbstractSince a hindfoot alignment is not included in the conventional mechanical axis (hip–ankle [HA] line), a mechanical axis including the calcaneus (hip–calcaneus [HC] line) has recently attracted attention as an alternative weight-bearing line. However, there are few reports on unicompartmental knee arthroplasty (UKA) regarding the HC line. Therefore, this study aimed to compare postoperative alignments after UKA between the HA line and the HC line. Postoperatively, HC radiographs were taken in 88 consecutive patients who underwent medial UKA. The hip–knee–ankle (HKA) and hip–knee–calcaneus (HKC) angles were compared in the same patient. Regarding tibial inclination, the conventional tibial component–ankle (TCA) angle was compared with reference to the HC line (tibial component–calcaneus [TCC] angle). The mean postoperative HKA and HKC angles were 2.8 ± 2.7 and 2.0 ± 2.5 degree, respectively. The mean postoperative TCA and TCC angles were 87.7 ± 2.1 and 88.5 ± 2.1 degree, respectively. There were significant differences between the two groups in both lower limb alignment and tibial component angle. The present study indicated that the HKC and the TCC angles significantly decreased the varus alignment by approximately 1 degree compared with the HKA and TCA angles. Neutral in the HA line corresponds to valgus in reference to the HC line, which may result in overcorrection. Surgeons should consider evaluating the HC line in place of the HA line, which may affect preoperative planning and postoperative outcome during UKA. This is a Level II, diagnostic study.
Vestibular Rehabilitation and Factors That Can Affect Outcome
Authors: Whitney Susan L. , Sparto Patrick J. , Furman Joseph M. 
Published: December 2019

AbstractThis review will discuss the developmental, environmental, medical, psychological, visual, and other sensory-related factors that affect recovery after vestibular dysfunction. A general overview of the evidence for vestibular rehabilitation for patients with peripheral and central vestibular disorders is provided. Recent findings suggest that age, physical activity, certain congenital disorders, length of symptoms, musculoskeletal, visual and neuromuscular comorbidities, cognition, sleep, and medications are all factors that influence the effectiveness and outcome of vestibular rehabilitation. Psychological factors that also affect outcome include anxiety, depression, fear of movement, and fear of falling. Recovery in patients with vestibular disorders may be enhanced if the practitioner recognizes and attempts to remediate modifiable factors.
Preoperative Performance of Patient-Reported Outcomes Measurement Information System in Patients with Meniscal Root Tears
Authors: Gulbrandsen Trevor R. , Khazi Zain M. , Bollier Matthew , Wolf Brian , Larson Christopher , Duchman Kyle , An Qiang , Westermann Robert W. 
Published: December 2019

AbstractThe purpose of this study was to establish preoperative validity of the Patient-Reported Outcomes Measurement Information System physical function computer adaptive test (PROMIS PF-CT) with legacy patient-reported outcome measures (PROMs) for meniscal root tears (MRTs). Our study included 51 patients (52 knees) with MRT. Patients completed PROMIS PF-CT, Short Form 36 (SF-36 physical function, pain, general health, vitality, social function, emotional well-being, role limitations due to physical health, and role limitations due to emotional problems), Knee Injury and Osteoarthritis Outcome Score (KOOS pain, symptoms, activities of daily living [ADLs], sports, and quality of life [QOL]), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC pain, stiffness, and function), EuroQol-5 dimensions (EQ-5D), and Knee Activity Scale questionnaires at their preoperative visit. Correlations between the PROMs listed above were evaluated along with floor and ceiling effects. Correlations were defined as weak (0.2–0.39), moderate (0.4–0.59), strong (0.6–0.79), and very strong (0.8–1.0). Preoperative data showed that PROMIS PF-CT has a strong correlation with SF-36 PF, KOOS-ADL, WOMAC-function, and EQ-5D; and moderate correlation with KOOS-sport, KOOS-pain, KOOS-symptoms, KOOS-QOL, WOMAC-pain, and WOMAC-stiffness. The Knee Activity Scale did not show any significant correlation with PROMIS PF-CT (r = 0.12, p = 0.2080). Of all the PROMs administered, PROMIS PF-CT demonstrated no floor or ceiling effects compared with 11.54% ceiling effect in KOOS-sports, and 5.77% floor effect in KOOS-ADL. On average, patients answered fewer PROMIS PF-CT questions (4.15 ± 0.72). PROMIS PF-CT is a valuable tool to assess preoperative patient-reported physical function in patients that may undergo MRT repair. It correlates strongly with other well-established PROMs. It also demonstrated no floor or ceiling effects and demonstrated a low test burden in our sample of 52 knees. This is a level III, prognostic retrospective comparative study.
Local Vancomycin Concentrations after Intra-articular Injection into the Knee Joint: An Experimental Porcine Study
Authors: Bue Mats , Thomassen Maja B. , Larsen Ole H. , Jørgensen Andrea R. , Stilling Maiken , Søballe Kjeld , Hanberg Pelle 
Published: December 2019

AbstractIntra-articular injection of vancomycin may be an important antimicrobial prophylactic supplement to systemic administration in the prevention of prosthetic joint infections. In eight female pigs, 500 mg of diluted vancomycin was given by intra-articular injection into the knee joint. Microdialysis was used for dense sampling of vancomycin concentrations over 12 hours in the synovial fluid of the knee joint, and in the adjacent femoral and tibial cancellous bone and subcutaneous tissue. Venous blood samples were obtained as reference. The mean (standard deviation [SD]) peak drug concentration of vancomycin in the synovial fluid of the knee joint was 5,277 (5,668) μg/mL. Only one pig failed to reach a peak drug concentration above 1,000 μg/mL. The concentration remained high throughout the sampling interval with a mean (SD) concentration of 337 (259) μg/mL after 690 minutes. For all extraarticular compartments, the pharmacokinetic parameters (area under the concentration time-curve, peak drug concentration, and time to peak drug concentration) were comparable. The highest extraarticular mean (SD) peak drug concentration of 4.4 (2.3) μg/mL was found in subcutaneous tissue. An intra-articular injection of 500 mg diluted vancomycin was found to provide significant prophylactic mean concentrations for at least 12 hours in the synovial fluid of the knee joint. Correspondingly, the adjacent tissue and plasma concentrations were low but remained stable, signifying low risk of systemic toxic side effects and a slow release or uptake from the synovium to the systemic circulation.
Extracellular Mitochondria in Traumatic Brain Injury Induced Coagulopathy
Authors: Zhao Zilong , Zhou Yuan , Li Min , Zhang Jianning , Dong Jing-Fei 
Published: December 2019

AbstractTraumatic brain injury (TBI) induced coagulopathy remains a significant clinical challenge, with unmet needs for standardizing diagnosis and optimizing treatments. TBI-induced coagulopathy is closely associated with poor outcomes in affected patients. Recent studies have demonstrated that TBI induces coagulopathy, which is mechanistically distinct from the deficient and dilutional coagulopathy found in patients with injuries to the body/limbs and hemorrhagic shock. Multiple causal and disseminating factors have been identified to cause TBI-induced coagulopathy. Among these are extracellular mitochondria (exMTs) released from injured cerebral cells, endothelial cells, and platelets. These circulating exMTs not only express potent procoagulant activity but also promote inflammation, and could remain metabolically active to become a major source of oxidative stress. They activate platelets and endothelial cells to propagate TBI-induced coagulopathy and secondary tissue injury after primary traumatic impact. In this review, we discuss recent advances in our understanding of the role of exMTs in the development of TBI-induced coagulopathy.
Genetic Background of von Willebrand Disease: History, Current State, and Future Perspectives
Authors: Zolkova Jana , Sokol Juraj , Simurda Tomas , Vadelova Lubica , Snahnicanova Zuzana , Loderer Dusan , Dobrotova Miroslava , Ivankova Jela , Skornova Ingrid , Lasabova Zora , Kubisz Peter , Stasko Jan 
Published: December 2019

AbstractSequencing of the gene encoding for von Willebrand factor (VWF) has brought new insight into the physiology of VWF as well as its pathophysiology in the context of von Willebrand disease (VWD). Molecular testing in VWD patients has shown high variability in the overall genetic background of this condition. Almost 600 mutations and many disease-causing mechanisms have been described in the 35 years since the VWF gene was identified. Genetic testing in VWD patients is now available in many centers as a part of the VWD diagnostic algorithm. Molecular mechanisms leading to types 2 and 3 VWD are well characterized; thus, information from genetic analysis in these VWD types may be beneficial for their correct classification. However, the molecular basis of type 1 VWD is still not fully elucidated and most likely represents a multifactorial disorder reflecting a combined impact of environmental and genetic factors within and outside of VWF. Regarding sequencing methods, the previous gold-standard Sanger sequencing is gradually being replaced with next-generation sequencing methods that are more cost- and time-effective. Instead of gene-by-gene approaches, gene panels of genes for coagulation factors and related proteins have recently become a center of attention in patients with inherited bleeding disorders, especially because a high proportion of VWD patients, mainly those with low VWF plasma levels (type 1), appear to be free of mutations in VWF. Whole-exome sequencing (WES) and whole-genome sequencing (WGS) are accessible in a very limited number of laboratories. Results from these studies have presented several genes other than VWF or ABO possibly affecting VWF levels, and such findings will need further validation studies.
Spectral principal component analysis of the Hβ region of low-redshift SDSS quasars
Authors: Ma Bin , Shang Zhaohui , Brotherton Michael S. 
Published: December 2019

Abstract
Studying the relationships among quasar spectral features is essential to unveil the origins of the emission lines and the quasars’ physical processes. Principal component analysis (PCA) is a powerful tool to investigate correlations between variables. Here, we present the results of PCA on the spectra of low-redshift SDSS quasars. The rest-frame wavelength range studied is 4000 – 5500 Å, involving some typical features of quasar spectra, such as Hβ, [O iii] and Fe ii emission lines. The first principal component is the anti-correlation between [O iii] and Fe ii, the well-known eigenvector one (EV1). The next six principal components also show clear (anti-)correlations between line strengths and/or velocity widths of various features, which agree well with measured spectral properties. By comparing the weights of these principal components with other quasar properties, we can identify their underlying drivers. We find that the second principal component represents spectral slope, and can quantify quasar host fraction, intrinsic slope and reddening well. The third component exhibits the velocity width variation of Hβ, and may be a proxy for orientation. In addition, we calculate the fractional-contribution spectra to investigate which components dominate the variance at individual wavelength ranges. Our results also indicate that the optical Fe ii emission may have distinct origins.
A photometric study of the high-mass-ratio contact binary AV Puppis
Authors: Han Quan-Wang , Li Li-Fang , Jiang Deng-Kai 
Published: December 2019

Abstract
The multi-color photometric light curves for contact binary AV Puppis (AV Pup) in VRcIc
bandpasses are presented and analyzed by using the 2013 version of the Wilson-Devinney (W-D) code. The solutions suggest that AV Pup is a peculiar A-subtype W UMa contact binary with a high mass ratio (q = m
2/m
1 = 0.896) and a low fill-out factor (f = 10%). Combining our newly determined times of minimum with those collected from literatures, the orbital period changes of this system are investigated. The O – C analysis indicates that the orbital period of AV Pup is increasing at a rate of dP/dt = 4.83 × 10−7 days yr−1, which can be explained by mass transfer from the less massive component to the more massive one.
A new strategy for estimating photometric redshifts of quasars
Authors: Zhang Yan-Xia , Zhang Jing-Yi , Jin Xin , Zhao Yong-Heng 
Published: December 2019

Abstract
Based on the SDSS and SDSS-WISE quasar datasets, we put forward two schemes to estimate the photometric redshifts of quasars. Our schemes are based on the idea that the samples are firstly classified into subsamples by a classifier and then a photometric redshift estimation of different subsamples is performed by a regressor. Random Forest is adopted as the core algorithm of the classifiers, while Random Forest and kNN are applied as the key algorithms of regressors. The samples are divided into two subsamples and four subsamples, depending on the redshift distribution. The performances based on different samples, different algorithms and different schemes are compared. The experimental results indicate that the accuracy of photometric redshift estimation for the two schemes generally improves to some extent compared to the original scheme in terms of the percents in

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and mean absolute error. Only given the running speed, kNN shows its superiority to Random Forest. The performance of Random Forest is a little better than or comparable to that of kNN with the two datasets. The accuracy based on the SDSS-WISE sample outperforms that based on the SDSS sample no matter by kNN or by Random Rorest. More information from more bands is considered and helpful to improve the accuracy of photometric redshift estimation. Evidently, it can be found that our strategy to estimate photometric redshift is applicable and may be applied to other datasets or other kinds of objects. Only talking about the percent in

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, there is still large room for further improvement in the photometric redshift estimation.
A new data structure for accelerating kinetic Monte Carlo method
Authors: Zheng Xu-Li , Quan Dong-Hui , Zhang Hai-Long , Li Xiao-Hu , Chang Qiang , Sipilä Olli 
Published: December 2019

Abstract
The kinetic Monte Carlo simulation is a rigorous numerical approach to study the chemistry on dust grains in cold dense interstellar clouds. By tracking every single reaction in chemical networks step by step, this approach produces more precise results than other approaches but takes too much computing time. Here we present a method of a new data structure, which is applicable to any physical conditions and chemical networks, to save computing time for the Monte Carlo algorithm. Using the improved structure, the calculating time is reduced by 80 percent compared with the linear structure when applied to the osu-2008 chemical network at 10 K. We investigate the effect of the encounter desorption in cold cores using the kinetic Monte Carlo model with an accelerating data structure. We found that the encounter desorption remarkably decreases the abundance of grain-surface H2 but slightly influences the abundances of other species on the grain.
Hydrodynamical simulations of the triggering of nuclear activities by minor mergers of galaxies
Authors: Yang Chao , Ge Jun-Qiang , Lu You-Jun 
Published: December 2019

Abstract
Major mergers of galaxies are considered to be an efficient way to trigger Active Galactic Nuclei and are thought to be responsible for the phenomenon of quasars. This has however recently been challenged by observations of a large number of low luminosity Active Galactic Nuclei at low redshift (z ≲ 1) without obvious major merger signatures. Minor mergers are frequently proposed to explain the existence of these Active Galactic Nuclei. In this paper, we perform nine high resolution hydrodynamical simulations of minor galaxy mergers, and investigate whether nuclear activities can be efficiently triggered by minor mergers, by setting various properties for the progenitor galaxies of those mergers. We find that minor galaxy mergers can activate the massive black hole in the primary galaxy with an Eddington ratio of f
Edd > 0.01 and > 0.05 (or a bolometric luminosity >1043 and >1044 erg s−1) with a duration of 2.71 and 0.49Gyr (or 2.69 and 0.19Gyr), respectively. The nuclear activity of the primary galaxy strongly depends on the nucleus separation, such that the nucleus is more active as the two nuclei approach each other. Dual Active Galactic Nuclei systems can still possibly be formed by minor mergers of galaxies, though the time duration for dual Active Galactic Nuclei is only ∼ 0.011 Gyr and ∼ 0.017 Gyr with Eddington ratio of f
Edd > 0.05 and bolometric luminosity >1044 erg s−1. This time period is typically shorter than that of dual Active Galactic Nuclei induced by major galaxy mergers.
Constraints on individual supermassive binary black holes using observations of PSR J1909–3744
Authors: Feng Yi , Li Di , Li Yan-Rong , Wang Jian-Min 
Published: December 2019

Abstract
We perform a search for gravitational waves (GWs) from several supermassive binary black hole (SMBBH) candidates (NGC 5548, Mrk 231, OJ 287, PG 1302–102, NGC 4151, Ark 120 and 3C 66B) in long-term timing observations of the pulsar PSR J1909–3744 obtained using the Parkes radio telescope. No statistically significant signals were found. We constrain the chirp masses of those SMBBH candidates and find the chirp mass of NGC 5548 and 3C 66B to be less than 2.4 × 109
M
⊙ and 2.5 × 109
M
⊙ (with 95% confidence), respectively. Our upper limits remain a factor of 3 to 370 above the likely chirp masses for these candidates as estimated from other approaches. The observations processed here provide upper limits on the GW strain amplitude that improve upon the results from the first Parkes Pulsar Timing Array data release by a factor of 2 to 7. We investigate how information about the orbital parameters can help to improve the search sensitivity for individual SMBBH systems. Finally, we show that these limits are insensitive to uncertainties in the Solar System ephemeris model.
The jet of FSRQ PKS 1229−02 and its misidentification as a γ-ray AGN
Authors: Zhao Wei , Hong Xiao-Yu , An Tao , Yang Jun 
Published: December 2019

Abstract
Flat-spectrum radio quasar PKS 1229–02 with a knotty and asymmetric radio morphology was identified as the optical and radio counterpart of a γ-ray source. In this paper, we study the properties (e.g. morphology, opacity, polarization and kinematics) of the jet in PKS 1229–02 using radio interferometry. With our results, we find that the knotty and asymmetric morphology of this source may probably shaped by the interaction between its anterograde jet and the nonuniform dense ambient medium. By reproducing a Spectral Energy Distribution of PKS 1229–02 with the obtained kinematic parameters, we find that the relativistic beaming effect in PKS 1229–02 is not strong enough to produce the reported γ-ray emission, i.e. PKS 1229–02 may not be a γ-ray AGN. The misidentification may probably be due to the poor spatial resolution of the γ-ray detector of the previous generation.
Alignment between satellite and central galaxies in the EAGLE simulation: dependence on the large-scale environments
Authors: Zhang Ming-Ge , Wang Yang 
Published: December 2019

Abstract
The alignment between satellite and central galaxies serves as a proxy for addressing the issue of galaxy formation and evolution, and has been investigated abundantly in observations and theoretical works. Most scenarios indicate that the satellites preferentially are located along the major axis of their central galaxy. Recent work shows that the strength of alignment signals depends on the large-scale environment in observations. We use the publicly-released data from EAGLE to figure out whether the same effect can be found in the associated hydrodynamic simulation. We found much stronger environmental dependency of alignment signals in the simulation. We also explore change of alignments to address the formation of this effect.