bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral health of children and adolescents with or without attention deficit hyperactivity disorder (ADHD) living in residential care in rural Rhineland-Palatinate, Germany
Authors: Ehlers Vicky , Callaway Angelika , Wantzen Sophia , Patyna Michael , Deschner James , Azrak Birgül 
Published: November 2019

AbstractBackgroundAttention deficit hyperactivity disorder (ADHD) is defined as childhood neurobehavioural disorder. Due to short attention span, oral hygiene and dental treatment of such individuals can be challenging. Aim of this study was to evaluate the oral health of children and adolescents with and without ADHD living in residential care in rural Rhineland-Palatinate, Germany.MethodsIncluded in the study were 79 participants (male/female:58/21, age 9–15 years) living in residential care: 34 participants with ADHD and 45 participants without ADHD (control). Oral examination included the following parameters decayed, missing, filled teeth in the primary dentition (dmft), decayed, missing, filled surfaces/teeth in the secondary dentition (DMFS/DMFT), approximal plaque index (API), bruxism and orthodontic treatment. Additionally, oral hygiene, last dental visit and treatment performed, and dietary habits were assessed by questionnaire.ResultsThere were no significant differences in dmft, API, bruxism and oral hygiene habits between groups. However, participants with ADHD tended to have higher DMFS/DMFT values than the control group. Ongoing orthodontic treatment was found more often in the control group. The ADHD group tended to consume acidic/sugary beverages and sweet snacks more often than the controls. Different treatments (control visit/prophylaxis, dental therapy, orthodontic treatment) were performed at the last dental visit in the two groups.ConclusionsWithin the limitations of this study,oral health was similar in children and adolescents with or without ADHD from the same residential care setting. Parents/guardians need instructions for better supervision of oral hygiene and dietary habits to improve the poor oral health of children with or without ADHD.
A bootstrapping approach for generating an inverse distance weight matrix when multiple observations have an identical location in large health surveys
Authors: Kim Sung Wook , Achana Felix , Petrou Stavros 
Published: November 2019

AbstractSpatial weight matrices play a key role in econometrics to capture spatial effects. However, these constructs are prone to clustering and can be challenging to analyse in common statistical packages such as STATA. Multiple observations of survey participants in the same location (or cluster) have traditionally not been dealt with appropriately by statistical packages. It is common that participants are assigned Geographic Information System (GIS) data at a regional or district level rather than at a small area level. For example, the Demographic Health Survey (DHS) generates GIS data at a cluster level, such as a regional or district level, rather than providing coordinates for each participant. Moreover, current statistical packages are not suitable for estimating large matrices such as 20,000 × 20,000 (reflective of data within large health surveys) since the statistical package limits the N to a smaller number. In addition, in many cases, GIS information is offered at an aggregated level of geographical areas. To alleviate this problem, this paper proposes a bootstrap approach that generates an inverse distance spatial weight matrix for application in econometric analyses of health survey data. The new approach is illustrated using DHS data on uptake of HIV testing in low and middle income countries.
The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst
Authors: Bu Zhiqin , Yang Xinhong , Song Lin , Kang Beijia , Sun Yingpu 
Published: November 2019

Abstract
Background
The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.

Methods
This observational cohort study included a total of 3091 patients undergoing their first frozen-thawed embryo transfer (FET) cycles between April 2015 to March 2019. Endometrial thickness was measured by trans-vaginal ultrasound twice for each patient: on day of progesterone administration, and on day of embryo transfer. The change of endometrial thickness was recorded.

Results
Regardless of endometrial preparation protocol (estrogen-progesterone/natural cycle), female age, body mass index (BMI), and infertility diagnosis were comparable between patients with an increasing endometrium on day of embryo transfer and those without. However, clinical pregnancy rate increases with increasing ratio of endometrial thickness. Compared with patients with Non-increase endometrium, those with an increasing endometrium on day of embryo transfer resulted in significantly higher clinical pregnancy rate (56.21% vs 47.13%, P = 0.00 in estrogen-progesterone cycle; 55.15% vs 49.55%, P = 0.00 in natural cycle).

Conclusions
In most patients, endometrial thickness on day of embryo transfer (after progesterone administration) increased or kept being stable compared with that on day of progesterone administration. An increased endometrium after progesterone administration was associated with better pregnancy outcome.
The pathogenesis of renal injury and treatment in light chain deposition disease
Authors: Wang Qi , Jiang Fang , Xu Gaosi 
Published: November 2019

AbstractLight chain deposition disease (LCDD) is a rare clinical disorder. The deposition of light chain immunoglobulins mainly affects the kidneys, which have different characteristics than other tissues. To date, the therapeutic approach for the treatment of LCDD has no evidence-based consensus, and clinical experience of reported cases guides current disease management strategies. The present systematic review investigates and summarizes the pathological mechanisms of renal injury and the subsequent treatments for LCDD.
Simultaneous, radiation-free registration of the dentoalveolar position and the face by combining 3D photography with a portable scanner and impression-taking
Authors: Ritschl Lucas M. , Wolff Klaus-Dietrich , Erben Pia , Grill Florian D. 
Published: November 2019

Abstract
Objectives
Simultaneous, radiation-free registration of the teeth and the upper and lower jaw positions in relation to the extraoral soft tissue could improve treatment planning and documentation. The purpose of this study is to describe a workflow to solve this form of registration and surface acquisition with a mobile device.

Methods
Facial scans of ten healthy participants were taken using a blue-light LED 3D scanner (Artec® Space Spider; Artec® Group; Luxembourg). An impression of the maxillary dentoalveolar arch was taken simultaneously to the 3D photo using a modified impression tray with two different extraoral registration geometries (sphere vs. cross). Following, an impression of the mandibular dentoalveolar arch was taken once. Both impressions were scanned with the 3D scanner. All resulting standard tesselation language (.stl) files of the geometries were compared to the original, virtual .stl files and the root mean square errors (RMSE) were calculated for each surface (Artec Studio 13 Professional × 64; Artec® Group; Luxembourg) to determine which geometry serves as a better reference for intra-extraoral registration.

Results
The RMSE between the original geometries and the scanned counterfeits were statistically lower for spherical geometries (p < 0.008). Once scanned and aligned, both geometries enabled an alignment of the intra- and extraoral scan. However, the spherical geometries showed virtually better results without significance (p = 0.70).

Conclusions
The presented study provides a radiation-free solution for simultaneous dentoalveolar correlations in relation to the extraoral soft tissue. Spherical geometries achieved more precise and easier intra-extraoral alignments using the applied mobile 3D scanner and workflow.
FGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-β/β-catenin pathway
Authors: Li Shuang-Qing , Tu Chao , Wan Lu , Chen Rui-Qi , Duan Zhi-Xi , Ren Xiao-Lei , Li Zhi-Hong 
Published: November 2019

Abstract
Background
Fibroblast growth factor (FGF) and tumor growth factor-β (TGFβ) have emerged as pivotal regulators during the progression of osteosarcoma (OS). LHX9 is one crucial transcription factor controlled by FGF, however, its function in OS has not been investigated yet.

Methods
The expression of LHX9, FRS2, BMP4, TGF-beta R1, SMAD2, beta-catenin and metastasis-related proteins was measured by real-time quantitative PCR (RT-qPCR) and Western blot. CCK-8 assay and colony formation assay were employed to determine the proliferation of OS cells, while scratch wound healing assay and transwell assay were used to evaluate their migration and invasion, respectively. In vivo tumor growth and metastasis were determined by subcutaneous or intravenous injection of OS cells into nude mice.

Results
LHX9 expression was evidently up-regulated in OS tumor tissues and cell lines. Knockdown of LHX9 impaired the proliferation, migration, invasion and metastasis of OS cells. Mechanistically, LHX9 silencing led to the down-regulation of BMP-4, β-catenin and metastasis-related proteins, which was also observed in beta-catenin knockdown OS cells. By contrast, FRS2 knockdown conduced to the up-regulation of LHX9, BMP4, β-catenin and TGF-βR1, while TGF-beta inhibition repressed the expression of LHX9 and metastasis-related proteins. Additionally, let-7c modulates LHX9 and metastasis-related proteins by suppressing TGF-beta R1 expression on transcriptional level.

Conclusions
This study revealed LHX9 was essential for the proliferation, migration, invasion, and metastasis of OS cells via FGF and TGF-β/β-catenin signaling pathways.
Copy number variations in candidate genomic regions confirm genetic heterogeneity and parental bias in Hirschsprung disease
Authors: Lantieri Francesca , Gimelli Stefania , Viaggi Chiara , Stathaki Elissavet , Malacarne Michela , Santamaria Giuseppe , Grossi Alice , Mosconi Manuela , Sloan-Béna Frédérique , Prato Alessio Pini , Coviello Domenico , Ceccherini Isabella 
Published: November 2019

Abstract
Background
Hirschsprung Disease (HSCR) is a congenital defect of the intestinal innervations characterized by complex inheritance. Many susceptibility genes including RET, the major HSCR gene, and several linked regions and associated loci have been shown to contribute to disease pathogenesis. Nonetheless, a proportion of patients still remains unexplained. Copy Number Variations (CNVs) have already been involved in HSCR, and for this reason we performed Comparative Genomic Hybridization (CGH), using a custom array with high density probes.

Results
A total of 20 HSCR candidate regions/genes was tested in 55 sporadic patients and four patients with already known chromosomal aberrations. Among 83 calls, 12 variants were experimentally validated, three of which involving the HSCR crucial genes SEMA3A/3D, NRG1, and PHOX2B. Conversely RET involvement in HSCR does not seem to rely on the presence of CNVs while, interestingly, several gains and losses did co-occur with another RET defect, thus confirming that more than one predisposing event is necessary for HSCR to develop. New loci were also shown to be involved, such as ALDH1A2, already found to play a major role in the enteric nervous system. Finally, all the inherited CNVs were of maternal origin.

Conclusions
Our results confirm a wide genetic heterogeneity in HSCR occurrence and support a role of candidate genes in expression regulation and cell signaling, thus contributing to depict further the molecular complexity of the genomic regions involved in the Enteric Nervous System development. The observed maternal transmission bias for HSCR associated CNVs supports the hypothesis that in females these variants might be more tolerated, requiring additional alterations to develop HSCR disease.
Is cranial multi-detector computed tomography imaging valuable for stature estimation in Egyptian population?
Authors: Adel Rana , Ahmed Hala Mohamed , Hassan Osama A. , Abdelgawad Ehab A. 
Published: November 2019

Abstract
Background and objectives
Stature estimation is an initial and essential component of any medico-legal investigations. However, it becomes more challenging when only skull remains are available. So, the goal of this study is to assess stature estimation using cranial multi-detector computed tomography (MDCT) images in a sample of the Egyptian population.

Methods
This clinical study was conducted on 150 Egyptian subjects underwent cranium MDCT with age ranged from 21 to 60 years. The measurements used were maximum cranial breadth, minimum frontal breadth, upper facial breadth, bizygomatic breadth, orbital height, orbital breadth, parietal chord, bimastoidale, maximum cranial length, basion-bregma height, cranial base length, and basion-prosthion length.

Results
The results revealed that stature and craniofacial measurements of males were significantly higher than those of females, all measurements were significantly positively correlated with stature in pooled cases, but the correlation coefficient differs in separate sex. Simple linear regression for stature estimation showed that the least standard error of estimate (SEE) values for the regression equations obtained when using bizygomatic breadth in pooled cases (7.9 cm) and in males only (5.7 cm), while in females using parietal chord had the least SEE (6.8 cm). Using multiple and stepwise regression analysis reported lower SEE values than simple linear regression analysis.

Conclusion
On the basis of this study, it is concluded that the cranial measurements obtained from MDCT images have limited utility in stature estimation among Egyptians, but could be used as an alternative method in cases where the best predictors, such as long bones, are not available.
Effects of Tai Chi and Qi Gong group class participation on self-reported symptoms in cancer patients and caregivers: A preliminary report.
Authors: Lopez Gabriel , Narayanan Santhosshi , Christie Amie J , Powers-James Catherine , Garcia M. Kay , Liu Wenli , Gomez Telma I , Wu Jimin , Williams Janet L. , Li Yisheng , Bruera Eduardo , Cohen Lorenzo 
Published: November 2019

100 Background: Tai chi and qi gong are movement-based, mind-body approaches offered as part of an integrative oncology program at a comprehensive cancer center. We explored the effects of tai chi and qi gong group class participation on cancer patient and caregiver self-reported symptoms. Methods: Patients and caregivers attending a tai chi and/or qi gong group class completed the Edmonton Symptom Assessment Scale (ESAS) immediately before and after participation. The ESAS assessed 10 symptoms (scale 0-10, 10 worst possible); ESAS subscales analyzed included global (GDS), physical (PHS), and psychosocial (PSS). Descriptive statistics; Chi-Squared test, Fisher’s exact test, Wilcoxon rank-sum test and Wilcoxon signed-rank test were used for data analysis. Results: 304 participants (Oct 2017-April 2019; 184 patients, 120 caregivers; 72% women, 60% white; mean age 58) were included in the analysis. For patients (symptom reduction by class type: tai chi -4.5 SD 7.6; qi gong -6.1 SD 7.9) and caregivers (tai chi -3.7 SD 6.3; qi gong -4.0 SD 7.8), both class types contributed to clinically and statistically significant improvement (ESAS GDS decrease ≥3; p’s ≤0.0001) in global distress. Patients (-2.07 SD 5.49) and caregivers (-2.34 SD 3.71) participating in tai chi experienced clinically and statistically significant improvement in physical distress (ESAS PHS decrease ≥2; p’s ≤0.0001). For the individual symptom of well-being, we observed clinically and statistically significant improvement for caregivers participating in qi gong (-1.2 SD 2) and patients participating in tai chi (-1.0 SD 1.8) (p’s ≤0.0001). For fatigue, patients (-1.4) and caregivers (-1.0) participating in qi gong experienced clinically and statistically significant improvement (p’s ≤0.0001). Conclusions: Patients and caregivers participating in both class types experienced significant improvement in physical and global distress. Additional research is warranted to learn more about how differences in class content (tai chi vs qi gong) and participants may contribute to observed differences in symptom change.
Frequency and severity of pain in hospitalized cancer patients at a tertiary cancer center.
Authors: Dalal Shalini , Reddy Akhila Sunkepally , Arthur Joseph Anthony , Haider Ali , Dev Rony , Williams Janet L. , Sobti Rahul , Tanco Kimberson Cochien , Bruera Eduardo 
Published: November 2019

103 Background: Recent regulations in response to the opioid crisis has presented unforeseen challenges in treating cancer patients with pain, such as frequent opioid shortages and clinicians moving away from prescribing opioids. This is especially concerning in cancer hospitals where a significant proportion of patients experience pain. Understanding the current frequency and severity of pain in hospitalized cancer patients are key hospital quality indicators, and will help in directing appropriate pain initiatives and resources. We aimed to determine the frequency, severity and changes in pain severity experienced by hospitalized cancer patients. Methods: The institutional electronic database was used to extrapolate pain scores for all cancer patients discharged over one year. The proportion of hospital-days with pain overall, on admission, and discharge is reported. A severe-pain day was a hospital-day with ≥ 1 severe pain score. A moderate-pain day was a non-severe pain day with ≥ 1 moderate pain score. Results: A total of 17097 unique patients accounted for 30056 hospital-days. Overall, the proportion of severe-, moderate-, mild-, and no pain-days was 29%, 23%, 10%, and 37% respectively. The monthly pain reports (Table) demonstrates no significant difference in pain frequency or severity over time. As compared to the first hospital-day, the proportion of severe pain days on discharge decreased from 33% to 16% (p <0.01) (Medical service 28% to 16%; Pediatrics 12% to 6%, Surgical 45% to 17%). Moderate- to-severe pain days decreased from 54% to 39% (p<0.01). Conclusions: A significant proportion of hospitalized cancer patients experience moderate-to-severe pain. Comprehensive assessment of the multiple dimensions of pain and strategies for early management are needed to reduce the number of moderate and severe pain days in the inpatient setting. [Table: see text]
A pilot study of oncology massage to treat chemotherapy-induced peripheral neuropathy (CIPN).
Authors: Lopez Gabriel , Eng Cathy , Overman Michael J. , Ramirez David Luis , Liu Wenli , Beinhorn Curtiss M , Sumler Pamela A , Prinsloo Sarah , Chen Minxing , Li Yisheng , Bruera Eduardo , Cohen Lorenzo 
Published: November 2019

111 Background: Short- and long-term toxicity of platinum compounds and taxanes includes development of CIPN. With an increased interest regarding the role of complementary approaches for symptom control, we investigated massage therapy for symptomatic relief of chronic CIPN. Methods: This pilot study evaluated the optimum treatment schedule and initial efficacy of a standardized Swedish massage technique to treat lower extremity (LE) CIPN. Inclusion criteria: LE neuropathy attributed to oxaliplatin, paclitaxel, or docetaxel, no other history of attributable causes; self-reported neuropathy score ≥3, 0-10 scale; ≥ 6 months since last chemotherapy treatment; age ≥ 18. Patients (pts) were randomized to one of four groups: 1) LE massage 3 times (3X) week for 4 weeks; LE massage 2X week for 6 weeks; 3) head/neck/shoulder (control) massage 3X week for 4 weeks; or 4) control massage 2X week for 6 weeks. Massage completion rate was examined and symptoms of CIPN measured with the Pain Quality Assessment Scale [PQAS (Range: 0-10); subscales of SP (surface pain), DP (deep pain), and PP (paroxysmal pain)] at baseline and at 10 weeks. Results: 71 pts fulfilled inclusion criteria: 77.5% women; 57.7% (breast cancer), and 42.3% (GI cancer); mean age 60.3 y/o (range: 40-77). Average length of time since the end of chemotherapy was > 3 yrs. Mean massage completion rates (max = 12) were 8.9 (SD 4.2) for 3X week and 9.8 (4.0) for 2X week with no statistical differences. There were no statistically significant differences in PQAS scores at follow-up between site-specific massage groups (lower extremity vs controls). Pts who had massage 3X week reported statistically and clinically significantly improved PQAS scores versus those who had massage 2X week (change scores: PQAS-SP: -2.3 vs. -0.6, p = 0.001; PQAS-DP: -2.1 vs. -0.9, p = 0.008; PQAS-PP: -2.3 vs. -1.0, p = 0.025), with sustained improvement in the 3X week group, but minimal change in the 2X week group. Conclusions: We observed sustained reduction in pts with long-term CIPN up to 6 weeks after treatment completion for the more intensive 3X week massage group, regardless of treatment site. A large-scale efficacy trial is warranted to validate the role of oncology massage therapy for CIPN. Clinical trial information: NCT02221700.
Relationship of physical function to outcomes in autologous hematopoietic stem cell transplantation.
Authors: Caveney Joseph , Kanate Abraham Sebastian , Hobbs Gerald , Swisher Anne 
Published: November 2019

116 Background: Physical function is an important consideration for autologous hematopoietic stem cell transplantation (auto-HSCT) but it is often judged subjectively rather than tested. This study examined the ability of functional test results to predict key transplant outcomes versus subjective rating. Methods: Patients receiving outpatient auto-HSCT performed a pre-transplant 2-minute walk test (2MWT), isometric handgrip testing, 5-times sit-to-stand test (5XSST) and timed up and go test (TUG). Karnofsky Performance Status (KPS) score was assigned by the treating oncologist. At day 100 following auto-HSCT, charts were extracted for age, gender, diagnosis, total number of hospital days, and days of platelet and neutrophil recovery. Predictions were determined through stepwise regression analysis. Results: Data from 37 patients (24 M, 13 F) were analyzed. The most common diagnosis was multiple myeloma. One patient expired prior to day 100. KPS was weakly correlated with all functional tests (spearman rho values 0.15 to 0.27, p values 0.07 to 0.32). KPS did not predict # hospital days (p = 0.53), neurophil recovery (p = 0.22) or platelet recovery (p = 0.51). In contrast, there was a trend for 5XSTS to predict # hospital days (p = 0.10), although predictive ability was low (R2 = 0.07). TUG was the best predictor of platelet recovery (p = .021), followed by 2MWT (p = 0.23) (R2 = 0.10). KPS did not predict any outcome measure, and none of the variables predicted neutrophil recovery. Conclusions: KPS does not correlate well with physical function testing nor does it predict key auto-HSCT short-term outcomes. While not a major contributor to hospitalization days or blood count recovery time, 5XSST and TUG appear to have potential to predict transplant outcomes. Future testing with larger samples is needed to determine the impact of physical function on long-term auto-HSCT outcomes.