bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of Total Daily Dose of Insulin in Type 1 Diabetic Pre-Menarchal vs Post-Menarchal Females
Authors: Sizemore Johnna M. , Stack Karolina , Bansal Sanjay K. , Sigman Garry , Joyce Cara 
Published: September 2020

Abstract
Study Objective Quantify the change of insulin requirements in pre- vs post-menarchal adolescent females with type 1 diabetes (T1DM) by measuring the total daily dose (TDD; units/kg/day) of insulin administered before vs after menarche in order to provide anticipatory guidance of insulin requirements in adolescent females as they progress through puberty to help reduce the long-term complications of poorly controlled T1DM. Design/Setting/Participants A retrospective chart review study was conducted which included 52 adolescent females with T1DM, after subjects who were diagnosed with T1DM after menarche, those on hormonal contraceptives, or those that had hypothyroidism, major medical comorbidities, or incomplete records were excluded. Subject demographics along with body mass index (BMI) percentile, HgbA1c (hemoglobin A1c), and TDD of insulin were collected 0-2 years pre-, 0-2 years post-, and 2-4 years post-menarche to assess differences in TDD of insulin in pre- and post-menarchal adolescent females with T1DM. Interventions None Main Outcome Measures TDD of insulin at 0-2 years pre-, 0-2 years post-, and 2-4 years post-menarche in adolescent females with T1DM. Results There was a statistically significant difference of TDD of insulin in pre- vs. post-menarchal adolescent females with T1DM after controlling for HgbA1c and BMI. Conclusions While poor glycemic control is often attributed to adolescent non-compliance of insulin administration, a physiologic process similar to polycystic ovarian syndrome may induce insulin resistance in post-pubertal adolescent females with T1DM.
Sensitivity of Prostate Cancer Foci using 1.5 T Multiparametric Magnetic Resonance Imaging
Authors: Ito Suguru , NAITO SEI , Narisawa Takafumi , Yagi Mayu , Kurota Yuta , Kanno Hidenori , Yamagishi Atsushi , Sakurai Toshihiko , Nishida Hayato , Yamanobe Takuya , Kato Tomoyuki , Tsuchiya Norihiko 
Published: September 2020

Abstract
Background: The detection of prostate cancer (CaP) has increasingly being carried out by multiparametric magnetic resonance imaging (mpMRI). Despite many previous studies, the sensitivity for clinically significant CaP (csCaP) was high, information on mpMRI false-negative lesions is limited. Therefore, the aim of this study was to evaluate the use and limitations of mpMRI in CaP.Methods: A total of 228 CaP foci in 100 patients who underwent 1.5 T mpMRI and radical prostatectomy between December 2015 and June 2017 were retrospectively analyzed. The sensitivities of CaP foci, csCaP, and index tumors (ITs) were measured. Clinically significant CaP was defined into two categories based on the Gleason score (GS): csCaP/GS ≥3 + 4 (GS ≥3 + 4 or diameter >10 mm) and csCaP/GS ≥4 + 3 (GS ≥4 + 3 or diameter >10 mm). In addition, the characteristics of false-negative lesions were identified. The Prostate Imaging Reporting and Data System version 2 was used to determine an mpMRI positive lesion, defined as a lesion having a score of ≥3.Results: The sensitivity of all legions, csCaP/GS ≥3 + 4, csCaP/GS ≥4 + 3, and ITs were 61.4%, 75.8%, 83.0%, and 91%, respectively. There were 91 lesions that were mpMRI false, 40% of which were csCaP/GS ≥3 + 4. There were three lesions with a GS of ≥8 and ≥10 mm in the false-negative results.Conclusions: mpMRI can highly detect ITs and csCaP/GS ≥4 + 3; however, a few large and high-GS CaPs constitute undetectable lesions in 1.5 T mpMRI.
Corded and hyalinized endometrioid carcinoma: a rare case and review of the literature
Authors: Li Yan , Lang Yuejiao , Yuan Kaitao , Tuo Ying , Xiang Pei , Zheng Donghua , Liu Dawei 
Published: September 2020

Abstract
Background

Corded and hyalinized endometrioid carcinoma(CHEC) is a rare morphological variation of endometrioid carcinoma(EC) in the endometrium. Reports of CHEC were very limited. We represent the clinical and pathological findings of this rare endometrioid carcinoma in a 26-year-old woman and reviews the literatures updated on CHEC.
Case presentation:

A 26-year-old woman presented with abnormal vaginal bleeding for 3 months and the initial cervical biopsy revealed a mullerian mixed tumor in another clinic. Abdominopelvic computed tomography revealed a mass in the uterine cavity and cervix, suggesting a malignant tumor. Histologically, the tumor showed a biphasic pattern characterized by an appearance of 2 components, the conventional endometrioid carcinoma component and sex cord-like component with hyalinization. In the areas of sex cord-like elements, the epithelioid and spindle cells were usually seen around the glands, and mostly arranged in cords or trabeculaes, sometimes embedded within a richly hyalinized collagenous or sometimes myxoid matrix. Tumor cells in the sex cord-like region show a different immunohistochemical expression pattern from conventional adenocarcinoma. Cytokeratin(CK) and vimentin are positive in both components, and vimentin shows more diffuse positivity while CK is more restricted and focally expressed in tumor cells in the sex cord-like region. Complete loss of expression of E-cadherin and epithelial membrane antigen(EMA) was seen in tumor cells in the sex cord-like region whereas it was well preserved in the area of conventional adenocarcinoma. Nuclear expression of β-catenin was noted in tumor cells in the sex cord-like region. P53 was focally positive in both components. Based on histological and immunochemical examinations, the patient was diagnosed with CHEC.
Conclusions

CHEC is not uncommonly mistaken for a wide variety of diseases. It’s of great significance to raise the awareness of CHEC to avoid over-treatment caused by over-diagnosis, especially in young patients and in curettage. We report one case of CHEC in a 26-year-old woman which was misdiagnosed as a mullerian mixed tumor in the initial curettage specimen. The clinicopathologic, light microscopic, immunohistochemical features of this tumor are described and the differential diagnosis is discussed.
Efficacy and Safety of Oral Micronized Progesterone That Converts to Allopregnanolone as an Adjunctive Treatment in Refractory Status Epilepticus: A Prospective Interventional Phase IIa Study
Authors: Sithinamsuwan Pasiri , Santimaleeworagun Wichai , Saelim Weerayuth , Samchai Sippanont , Ruttanajirundorn Puntawat , Senngam Marisa , Onsombat Wisithipong , Suphanklang Juthathip 
Published: September 2020

Abstract
Background: We aimed to study the efficacy and safety of allopregnanolone which convert from oral micronized progesterone as an adjunctive treatment for Thai patients with refractory status epilepticus.Methods: Adults 18–80 years old who diagnosed with either convulsive or non-convulsive refractory status epilepticus receiving standard AED treatment, intravenous midazolam, for longer than 60 minutes were included. The intervention group received Utrogestran® (micronized progesterone, 200 mg/capsule) via enteric feeding every 8 h for five days. Treatments for RSE were continuing along the clinical trial period. Serum allopregnanolone levels were measured by radioimmunoassay (DetectX® Allopregnanolone Immunoassay Kit; Arbor Assays, Michigan, United States). Control patients were randomly selected from our hospital RSE cohort during 2015–2019. Continuous data were presented as the mean and standard deviation. Discrete data were assessed by number and percentage. The changes in laboratories were analyzed by paired t-test. The difference between groups were compared by independent sample t-test. The Mann-Whitney U test, Chi-square test or Fisher’s exact test were used for non-parametric parameters. A p-value < 0.05 indicated statistical significance. All analyses were performed using SPSS version 26 software (IBM Corp., Armonk, NY).Results: The average duration of refractory status epilepticus after treatment with midazolam plus progesterone (intervention group) and without progesterone until status epilepticus termination was 25.5 and 58.4 hours, (p = 0.004), indicated that allopregnanolone significantly shortens the refractory status epilepticus duration in vivo.Conclusions: Allopregnanolone, produced from oral micronized progesterone, demonstrates efficacy and safety in treating refractory status epilepticus as an adjunctive treatment.Trial registration: This trial was registered in Thai Clinical Trials Registry (TCTR) database. The trial registration number was “TCTR20200717002”, 16 July 2020, retrospectively registered.
Long-Term Efficacy and Safety of Intravenous Injection of Clonal Mesenchymal Stem Cells Derived From Bone Marrow in Five Adults With Moderate to Severe Atopic Dermatitis
Authors: Shin Hyun-Tae , Lee Si Hyub , Yoon Hee Seong , Heo Ji Hye , Lee Seon Bok , Byun Ji Won , Shin Jeonghyun , Cho Yun-Kyoung , Chung Eunkyung , Jeon Myung-Shin , Song Sun U. , Choi Gwang Seong 
Published: September 2020

Abstract
Atopic dermatitis is a chronic and relapsing inflammatory skin disease that is treated with immunosuppressants. However, long-term use of immunosuppressants may cause toxicity and severe side effects. To confirm the long-term efficacy and safety of clonal mesenchymal stem cell therapy, we performed investigator-initiated clinical trials and long-term observation in five adult patients with moderate to severe atopic dermatitis that was refractory to conventional treatments. The clinical response assessment values such as eczema area and severity index (EASI) improved significantly at 16 weeks, and 80% (4/5) of the patients achieved EASI-50 after one or two treatment cycles. Patients were observed for long-term efficacy and safety for an average of 38 weeks (range: 16–86 weeks) and showed no serious side effects. Among the cytokines tested, CCL-17, IL-13 and IL-22 significantly decreased at the endpoint of the five participants, two patients who maintained good clinical response over 84 weeks showed increased IL-17 cytokine levels in the blood.
Functional drug–target–disease network analysis of gene–phenotype connectivity for curcumin in cancer
Authors: Zhao Yuanyuan , Tao Jiahao , Chen Zhuangzhong , Li Suihui , Liu Zeyu , Lin Lizhu , Zhai Linzhu 
Published: September 2020

Abstract
Background

The anti-tumor properties of curcumin have been elucidated in many cancer types. However, a systematic functional and biological analysis related to its target proteins has yet to be documented fully. The aim of this study was to explore the underlying mechanisms of curcumin and broaden the perspective of targeted therapies.
Methods

Direct protein targets (DPTs) of curcumin were searched in the DrugBank database. Using the STRING database, the interaction between curcumin and DPTs and indirect protein targets (IPTs) was documented. The protein–protein interaction (PPI) network of curcumin-mediated proteins was visualized using Cytoscape. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was performed for all curcumin-mediated proteins. Furthermore, the cancer targets were searched in the Comparative Toxicogenomics Database (CTD). The overlapping targets were studied using Kaplan–Meier analysis to evaluate cancer survival. Further genomic analysis of overlapping genes was conducted using the cBioPortal database. Lastly, CKK-8, qPCR, and WB analysis were used to validate the predicted results on HCC cells.
Results

A total of 5 DPTs and 199 IPTs were found. These protein targets were found in 121 molecular pathways analyzed via KEGG enrichment. Based on the anti-tumor properties of curcumin, two pathways were selected, including pathways in cancer (36 genes) and hepatocellular carcinoma (HCC) pathway (22 genes). Overlapping with 505 HCC-related gene sets identified in CTD, five genes (TP53、 RB1、 TGFB1、 GSTP1、 and GSTM1) were finally identified. High mRNA levels of TP53, RB1, and GSTM1 indicated a prolonged OS in HCC, while elevated mRNA levels of TGFB1 were correlated with poor prognosis. The viability of HepG2 cells and Hep3B cells can both be significantly reduced by curcumin at concentrations of 20 or 30 µM after 48 or 72 h of culture. At a concentration of 20 µM curcumin, the expression of TGFB1 and GSTP1 in Hep3B cells was reduced significantly in qPCR analysis, and reduced TGFB1 protein expression was also found in Hep3B cells.
Conclusions

The current results provided evidence that curcumin has the potential to become an alternative chemotherapy or chemoprevention for HCC.
Adapted Diving Mask Bench Tests as an Autonomous Respiratory Support in Healthy Volunteer
Authors: Arias-Arcos Beatriz , Collado-Escudero Carlos , Candelario-Cáceres Ariela , Buendia-García Maria Jesus , Abad-Gurumeta Alfredo , Mendiguren-Santiago Jose María , Larrainzar-Garijo Ricardo 
Published: September 2020

Abstract
PurposeThe scenario of global health crisis due to SARS-CoV-2 pandemia combined with the shortage of resources in many countries has justified numerous studies to design easily replicable and economic respiratory support devices. We have developed an adapted diving mask (ADM) to be used as an autonomous and safe respiratory support. The objective was to prove a minimum positive end expiratory pressure (PEEP) with the ADM without any adverse events.MethodsBench tests was done in 22 healthy volunteers with our ADM prototype. Expiratory-inspiratory flow and pressure were registered apart from blood and transcutaneous hypercapnia.ResultsThere were no statistically significant differences in the baseline analysis results and after therapy, except in pO2. Mean PEEP measured was 8.2 ± 4.2 cmH2O with a peak measured pressure of 20 cm H2O.ConclussionsThe ADM has shown good tolerance and a therapeutic manteining PEEP with no evidence of any deletereous effect or hypercapnia with its continuous use.
The Effect of Entrepreneurial Orientation on Business Performance: A Comparative Study of Necessity and Opportunity Entrepreneurs by Gender
Authors: Ndikubwimana Jean Bosco , Mukasekuru Alice , Ndizeye Idrissa , Mutesi Josephine , Byukusenge Eugenie 
Published: September 2020

Abstract
Entrepreneurship is known, contribute to the economic growth locally as well as globally. To make entrepreneurship play its economic role, entrepreneurs are oriented by different factors and perform differently in their business. This lead the researchers to investigate the entrepreneurial orientation considering necessity and opportunity factors among women and men business owners and their owned businesses in Huye District. This was done to find out the effect of such orientation on their business performance and to examine the significance of cross-gender differences with regard to the variables under study. For achieving the above objectives; structured questionnaire and documentary review techniques were used to collect data. From total population of 1787 business owners identified from 11 sectors in Huye District, researchers sampled 327 respondents. Random and convenience sampling techniques were used. The results showed that both males and females are more opportunity oriented than necessity oriented. Study shows that business owned by males perform better than business owned by females regarding both financial and non-financial performance aspects. It was also found out that there are no significant differences in both levels of entrepreneurial orientation and business performance across gender. Correlation analysis revealed a significant relationship between entrepreneurial orientation of women and men business owners and their business performance. Based on these findings, it recommends that the Government of Rwanda (GoR) should focus training and sensitization for women to increase their involvement in business and improve the performance of existing women business owners. Improving entrepreneurship program by MINEDUC should also be given consideration especially at primary and secondary levels/educations to prepare potential entrepreneurs.
Analysis of Radiographic Spinopelvic Parameters in Patients With Degenerative Lumbar Kyphoscoliosis
Authors: Rile Ge , Yang Peng , Liu Xin , Wen Bingtao , Guo Zhaoqing , Chen zhongqiang 
Published: September 2020

Abstract
Purpose: To analyze the relationships between coronal and sagittal spinopelvic parameters in degenerative lumbar kyphoscoliosis (DLKS).Methods: We enrolled 75 patients with DLKS for a radiographic study between January 2016 and September 2018. Correlations between coronal and sagittal spinopelvic radiographic parameters were analyzed. Then patients were divided into two groups: sagittal balanced group (SVA<= 5cm, 30 patients) and sagittal imbalanced group (SVA> 5cm, 45 patients), and relevant parameters were compared.Results: The Cobb angle and lumbar lordosis of the DLKS patients were 24.87 ± 11.59° and 17.26 ± 12.24°, respectively. The average age was 68 years old (range: 42-82), and the sex ratio was 2.6:1 (female:54 patients; male: 21 patients). 50 patients (66.7%) located convexity of the curve at left side, while 25 patients (33.3%) at right side. The Cobb angle correlated with LL-TK (r = -0.228, p = 0.049), LL (r = -0.255, p = 0.027) and SS (r = -0.232, p = 0.045). There were significant differences in PI-LL (t = -3.484, P = 0.001), LL-TK (t = 2.354, P = 0.023), PI (t = -3201, P = 0.002) and PT (t = -2.521, P = 0.014) between sagittal balanced and imbalanced group. Conclusions: In degenerative lumbar kyphoscoliosis, there are some correlations between coronal and sagittal spinopelvic parameters. Moreover, PI-LL, LL-TK, PI, PT were significantly different between sagittal balanced and imbalanced DLKS patients.
The clinical and angiographic outcomes of post-dilation after percutaneous coronary intervention in patients with acute coronary syndrome: a systematic review and meta-analysis
Authors: Li Yan , Liang Xiying , Zhang Wenjiao , Qiao Xuan , Wang Zhilu 
Published: September 2020

Abstract
Background

Optimal stent deployment is closely related to the prognosis of patients with coronary artery disease, but the effect of post-dilation on clinical and angiographic outcomes in patients with acute coronary syndrome is still controversial. This meta-analysis aims to analyze the clinical and angiographic outcomes of post-dilation after percutaneous coronary intervention in patients with acute coronary syndrome.
Methods

PubMed, Embase, The Cochrane Library, Web of Science, CNKI and WANGFANG date-bases were searched from inception to August 30, 2020. Eligible studies from acute coronary syndrome patients treated with post-dilation were included. The primary clinical outcome was major adverse cardiovascular events (MACE), the secondary clinical outcomes were comprised of all-cause death, stent thrombosis, myocardial infarction, and target vessel revascularization, the angiographic outcomes were no reflow and slow reflow.
Results

A total of 11 studies enrolling 5663 patients met inclusion criteria. Our pooled analysis demonstrated that the post-dilation did not have significant impact on MACE (OR = 0.76, 95% CI 0.50–1.17; P = 0.21), stent thrombosis (OR = 0.71, 95% CI 0.40–1.26; P = 0.24), myocardial infarction (OR = 0.14, 95% CI 0.51–3.83; P = 0.51), and target vessel revascularization of clinical outcomes (OR = 0.61, 95% CI 0.21–1.80; P = 0.37) between post-dilation and non-post-dilation groups, but increased the risk of all-cause death (OR = 1.49, 95% CI 1.05–2.19; P = 0.03). There were no significant difference in no reflow (OR = 1.19, 95% CI 0.54–2.65; P = 0.66) and slow reflow (OR = 1.12, 95% CI 0.93–1.35; P = 0.24) of angiographic outcomes between two groups.
Conclusions

The post-dilation can increase the risk of all-cause death, without affecting the risks of MACE, stent thrombosis, myocardial infarction, target vessel revascularization, no reflow and slow reflow. However, more randomized controlled trials are required for investigating the benefits of post-dilation for patients with acute coronary syndrome (Registered by PROSPERO, CRD42020160748).
Health-Related Quality of Life of Military Policemen in Salvador, Brazil: Cross-Sectional Study.
Authors: Barreto Carla Requião , Carvalho Fernando Martins , Lins-Kusterer Liliane 
Published: September 2020

Abstract
Background: Brazil is a violent society and police officers play a fundamental role in this scenario. Police work is a stressful occupation. Dealing with routine violence, police officers must have high standards of physical and mental health. Patrolling the streets involves several risks and stressful situations that may hamper military policemen's quality of life. This study aimed to identify factors associated with health-related quality of life in military policemen. Methods: A cross-sectional design study investigated a random sample of 329 male military police officers, engaged in patrolling the streets of Salvador, Bahia, Brazil. A structured questionnaire was applied to the policemen during their working hours. Information was collected about age, education, marital status, housing, car ownership, police rank, working day, alcohol consumption, smoking, frequency of vigorous physical activity and weight and height, in order to calculate body mass index. Health-related quality of life was evaluated through the 36-Item Short Form Survey Questionnaire (SF-36). Work ability was assessed through the Work Ability Index questionnaire. Poor work ability was defined by a Work Ability Index 7-27 points. Multivariable linear regression models were used to measure the impact of police officer characteristics on variation in the Physical Component and Mental Component Summary scores.Results: Normalised scores were below 50.0 for seven out of the eight SF-36 domains and for the two component summaries. The SF-36 Physical Component Summary was associated with poor work ability, while the Mental Component Summary was associated with poor work ability, excessive alcohol consumption, and younger age. Poor work ability affected 10.3% of the workforce. Decreases of 7.363 units (%) in the Physical Component Summary mean and of 12.862 units (%) in the Mental Component Summary mean were estimated for policemen with poor work ability.Conclusions: The military police officers investigated presented poor health-related quality of life, associated with younger age, excessive alcohol consumption, and poor work ability, which may hamper the performance of their professional activities.