bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-stigma in serious mental illness and autism spectrum disorder: Results from the REHABase national psychiatric rehabilitation cohort
Authors: Dubreucq J. , Plasse J. , Gabayet F. , Faraldo M. , Blanc O. , Chereau I. , Cervello S. , Couhet G. , Demily C. , Guillard-Bouhet N. , Gouache B. , Jaafari N. , Legrand G. , Legros-Lafarge E. , Pommier R. , Quilès C. , Straub D. , Verdoux H. , Vignaga F. , Massoubre C. ,   REHABAse Network, Franck N. 
Published: February 2020

Abstract

Background.
Self-stigma
is a major issue in serious mental illness (SMI) and is negatively associated with patient outcomes. Most studies have been conducted in schizophrenia (SZ). Less is known about self-stigma in other SMI and autism spectrum disorder (ASD). The objectives of this study are: (i) to assess the frequency of self-stigma in a multicentric nonselected psychiatric rehabilitation SMI and ASD sample; and (ii) to investigate the correlates of elevated self-stigma in different SMI conditions and in ASD.

Methods.
A total of 738 SMI or ASD outpatients were recruited from the French National Centers of Reference for Psychiatric Rehabilitation cohort (REHABase). Evaluations included sociodemographic data, illness characteristics, and standardized scales for clinical severity, quality of life, satisfaction with life, wellbeing, personal recovery, a large cognitive battery, and daily functioning assessment.

Results.

31.2% of the total sample had elevated self-stigma. The highest prevalence (43.8%) was found in borderline personality disorder and the lowest (22.2%) in ASD. In the multivariate analysis, elevated self-stigma was best predicted by early stages of personal recovery (moratorium, p = 0.001, OR = 4.0 [1.78–8.98]; awareness, p = 0.011, OR = 2.87 [1.28–6.44]), history of suicide attempt (p = 0.001, OR = 2.27 [1.37–3.76]), insight (p = 0.002, OR = 1.22 [1.08–1.38]), wellbeing (p = 0.037, OR = 0.77 [0.60–0.98]), and satisfaction with interpersonal relationships (p < 0.001, OR = 0.85 [0.78–0.93]).

Conclusions.
The present study has confirmed the importance of addressing self-stigma in SMI and ASD patients enrolled in psychiatric rehabilitation. The effectiveness of psychiatric rehabilitation on self-stigma and the potential mediating effects of changes in self-stigma on treatment outcomes should be further investigated.
Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk
Authors: Cristóbal-Narváez Paula , Sheinbaum Tamara , Rosa Araceli , de Castro-Catala Marta , Domínguez-Martínez Tecelli , Kwapil Thomas R. , Barrantes-Vidal Neus 
Published: February 2020

Abstract

Background.
There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 51 (FKBP5) variability moderates the association of positive and negative experiences in the moment with PEs and NA in participants with incipient psychosis and their nonclinical counterparts.

Methods.
A total of 233 nonclinical and 86 incipient psychosis participants were prompted for a 1-week period to assess their day-to-day experiences. Participants were genotyped for four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080).

Results.
Multilevel analyses indicated that, unlike the risk haplotype, the protective FKBP5 haplotype moderated all the associations of positive experiences with diminished PEs and NA in incipient psychosis compared with nonclinical group.

Conclusions.
Participants with incipient psychosis showed symptomatic improvement when reporting positive appraisals in the interpersonal domain, which suggests that these act as a powerful coping mechanism. The fact that this occurred in daily-life underscores the clinical significance of this finding and pinpoints the importance of identifying protective mechanisms. In addition, results seem to concur with the vantage sensitivity model of gene–environment interaction, which poses that certain genetic variants may enhance the likelihood of benefiting from positive exposures.
Nonmyeloablative Alternative Donor Transplantation for Hodgkin and Non-Hodgkin Lymphoma: From the LWP-EBMT, Eurocord, and CIBMTR
Authors: Fatobene Giancarlo , Rocha Vanderson , St. Martin Andrew , Hamadani Mehdi , Robinson Stephen , Bashey Asad , Boumendil Ariane , Brunstein Claudio , Castagna Luca , Dominietto Alida , Finel Hervé , Chalandon Yves , Kenzey Chantal , Kharfan-Dabaja Mohamed , Labussière-Wallet Hélène , Moraleda Jose M. , Pastano Rocco , Perales Miguel-Angel , El Ayoubi Hanadi Rafii , Ruggeri Annalisa , Sureda Anna , Volt Fernanda , Yakoub-Agha Ibrahim , Zhang Mei-Jie , Gluckman Eliane , Montoto Silvia , Eapen Mary 
Published: February 2020

PURPOSETo compare the outcomes of patients with Hodgkin or non-Hodgkin lymphoma undergoing nonmyeloablative haploidentical or unrelated cord blood (UCB) hematopoietic cell transplantation.PATIENTS AND METHODSWe retrospectively studied 740 patients with Hodgkin lymphoma (n = 283, 38%) and non-Hodgkin lymphoma (n = 457, 62%) age 18-75 years who received transplantations from 2009 to 2016. Data were reported to the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation, Eurocord, or Center for International Blood and Marrow Transplant Research. Of the 526 patients who received haploidentical transplantation, 68% received bone marrow and 32% received peripheral blood. All patients received a uniform transplantation conditioning regimen (2 Gy of total-body irradiation, cyclophosphamide, and fludarabine) and graft-versus-host disease prophylaxis (calcineurin inhibitor and mycophenolate). In addition, patients who received a haploidentical transplantation received posttransplantation cyclophosphamide.RESULTSCompared with haploidentical bone marrow and peripheral-blood transplantations and adjusted for age, lymphoma subtype, and disease status, survival was lower after UCB transplantation (hazard ratio [HR], 1.55; P = .001; and HR, 1.59; P = .005, respectively). Similarly, progression-free survival was lower after UCB transplantations compared with haploidentical bone marrow and peripheral-blood transplantations (HR, 1.44; P = .002; and HR, 1.86; P < .0001), respectively. The 4-year overall and progression-free survival rates after UCB transplantation were 49% and 36%, respectively, compared with 58% and 46% after haploidentical bone marrow transplantation and 59% and 52% after peripheral-blood transplantation, respectively. Lower survival was attributed to higher transplantation-related mortality after UCB transplantation compared with haploidentical bone marrow and peripheral-blood transplantation (HR, 1.91; P = .0001; and HR, 2.27; P = .0002, respectively).CONCLUSIONWhen considering HLA-mismatched transplantation for Hodgkin or non-Hodgkin lymphoma, the data support haploidentical related donor transplantation over UCB transplantation.
The Family Novel (and Its Curious Disappearance)
Authors: Berman Anna A. 
Published: February 2020

AbstractWhat is a family novel? Russian literary scholars—who use the term frequently—claim that it is originally an English genre, yet in English scholarship the term has virtually disappeared. This article recovers the lost history of the family novel, tracing two separate strands: usage of the term and form/content of the novels. The genre began in England with Richardsonian domestic fiction and spread to Russia, where it evolved along different lines, shaped by the different social and political context. In England, the fate of the term turns out to be tied up with the fate of women writers in the nineteenth century, and then with the rise of feminist studies in the late twentieth that, in validating the importance of the domestic sphere, caused family novel to be superseded by domestic fiction. In Russia, by contrast, the great family novels of the nineteenth century were not associated with women or the domestic sphere, nor—as it turns out—were they considered to be family novels at the time they were written. Only in twentieth-century scholarship, as the original meaning of the term was lost, did they become family novels. In recovering the lost history of the term, this article illustrates the way later ideology and theoretical emphases that shape the language of scholarship ultimately reshape our understanding of the past.
Toward an Aesthetics of Obscurity: From Baumgarten to Blanchot
Authors: Rosenbrück Jonas 
Published: February 2020

Abstract
This article analyzes the notions of clarity and obscurity in the work of Alexander Gottlieb Baumgarten and Maurice Blanchot, arguing that the latter’s thought of the “other night” proposes a radical reversal, indeed, a corruption, of Baumgarten’s founding of aesthetics as an ocularcentric discipline governed by clarity. Baumgarten, laying the groundwork for much of the “distribution of the sensible” that dominated the field of aesthetics after him, conceives of the poem as the paradigmatic instance of an aesthetic cognition of the sensible that is founded on the triad of clarity, attention, and liveliness. He thus opposes the poem to both the obscure fundus animae, the ground of the soul, and to utopian poetry, neither of which can be poetized. By contrast, Blanchot’s literature dissolves this triple foundation into a writing of obscurity, distracted fatigue, and a “death resurrected”; literature opens aesthetics to that which had been constitutively excluded at its founding moment. The clarifying powers of the poet-aesthetician are replaced by passive “fascination” and a “passion of the image” that delimits a radically different, countercosmic, and thus utopian space of literature.
Marx as a Model and Question: Alexander Kluge’s Critical Inquiries
Authors: Walzer Dorothea 
Published: February 2020

Abstract
Alexander Kluge’s oeuvre features aesthetic commentary as a process of problematization and investigation. With exemplary case studies of Kluge’s films, his literary collections of short stories, his television interviews, and his theory volumes composed with Oskar Negt, this article analyzes not only various forms of questions posed in these genres but also the epistemological dimension of questioning. This perspective reveals how a Marxian model of writing becomes the point of departure for Kluge’s work on artistic method. It demonstrates that his questioning concerns the disclosure of subtexts, contexts, and peripheral texts that otherwise remain unseen. As a form of dual documentation—both scientific and artistic, objective and subjective—aesthetic commentary can be read against contemporary claims that the fictionality of a “postfactual age” replaces reality after the end of the “critical age.”
Urban, Historical, and Musical Loops: László Moholy-Nagy, Alexander Kluge, and the City Symphony Film
Authors: Haenni Sabine 
Published: February 2020

Abstract
Focusing on Alexander Kluge’s short film Chicago im Zeitraffer (Chicago in Time Lapse), this article inserts his work with moving images into a larger genealogy of the city symphony film. Elucidating his relationship with the historical cinematic avant-garde, as Kluge borrows and departs from both László Moholy-Nagy’s urban vision and Bertolt Brecht’s conception of urban capitalist modernity, the article shows that Kluge’s film reorients time-lapse cinematography and opens up a new form of perception. By incorporating transnational techno music, the film suggests a concept of body and subjectivity that appears as a consequence of an increasingly voracious capitalist modernity while embedding a sense of obstinacy and self-propulsion. Nonetheless, the film’s reliance on transatlantic techno risks excluding the Black musical and social contexts that inspired it. Throughout the article the “loop,” or the traffic circle (Kreisverkehr), is understood as a governing metaphor that helps explain Kluge’s vision of contemporary urbanity, historical connectivity, and musical influence.
Contaminated Soulscapes and Landscapes in Maja Haderlap’sEngel des Vergessens/Angel of Oblivion
Authors: Siller Barbara 
Published: February 2020

AbstractThis article discusses contaminated soulscapes and landscapes in southern Carinthia in Austria as narrated in Maja Haderlap’s novel Engel des Vergessens (Angel of Oblivion, 2011). Since a large part of the Slovenian population in southern Carinthia joined the partisans during World War II and thus resisted the Nazis, it is a highly contaminated space, where local battles took place and hidden graves are ubiquitous. The article examines the representation of these tainted landscapes in Haderlap’s novel. It emphasizes the contaminated soulscapes of the portrayed characters and positions soulscapes and landscapes in close connection to each other. It argues that the characters’ traumatic experiences not only are inscribed as bodily memories but also become part of their language. Rather than engage with the wider field of trauma theories, this article focuses on the main characters of the three generations, grandmother, son, and granddaughter, whereby it becomes obvious that Haderlap’s text supports the idea of transgenerational memories. By discussing the narrative choices for portraying the memories, the article argues that through specific strategies the text displays the interconnectedness between past, present, and future as well as the complexity of remembering processes.
Service quality in the healthcare sector: do human resource management practices matter?
Authors: Jacob SC , Manalel J , Minimol MC 
Published: February 2020

Background/aimsService quality in hospitals is determined by the quality of staff interactions with patients. Human resource (HR) management practices play a significant role in the recruitment and retention of high calibre hospital staff. This study aimed to investigate how HR management practices affect employees' performance-related outcomes, such as their commitment to delivering a good standard of care and their perceptions of the quality of service that their hospital provides.MethodsAn integrated causal model was designed and tested by surveying the staff of hospitals in India. A total of 1236 usable response sets were analysed through structural equation modelling to test the relationships between HR management practices and employee performance-related outcomes.ResultsAll but two of the relationships described by the model were found to be significant. The relationship between employees' commitment to their organisation and their perceptions of the service's quality and the relationship between HR management practices and employee commitment to delivering good service quality were found to be non-significant.ConclusionThe integrated causal model could help healthcare managers to identify and strategically plan HR management practices to target desired employee performance-related outcomes in the hospital sector.
Women's decision-making about mode of birth after a previous caesarean section
Authors: Fumagalli Simona , Colciago Elisabetta , Antolini Laura , Perego Sofia , Fiorasi Micaela , Fossati Valeria , Nespoli Antonella , Vergani Patrizia 
Published: February 2020

Background Evidence on the safety and appropriateness of vaginal birth after caesarean (VBAC) appears clear, but knowledge about women's choice towards this mode of birth is limited. Aims To identify variables related to women's decision-making about whether to try for VBAC. Method and findings Cross-sectional study was conducted. Feelings of body failure towards the previous birth and the desire to have a vaginal birth were associated with maternal choice of VBAC. Women who perceived a repeated section as being dangerous for them opted for a VBAC (p=0.030). Opinion of women with the same experience and information found online were implicated into maternal decision-making. Conclusion This is the first Italian study to confirm that maternal choice is complex and involves many factors. Midwives and obstetricians should strive to provide an evidence-based midwifery care, in order to offer a VBAC as a safe birth option.
Trastuzumab Emtansine (T-DM1): Hitching a Ride on a Therapeutic Antibody
Authors: Burris Howard A. 
Published: February 2020

Overview: The treatment of cancers with chemotherapy is frequently limited by side effects. The effectiveness may be improved by the use of monoclonal antibodies to deliver cytotoxic agents to cancer cells while limiting exposure to normal tissues. The use of antibody-drug conjugates (ADCs) is one such strategy: a drug connected by a linker to an antibody specific for a tumor antigen is the basic makeup of an ADC. Overexpression and amplification of HER2 is associated with clinically aggressive breast cancers, and the use of trastuzumab to target HER2 has been highly effective. That said, most patients with HER2-positive metastatic breast cancer will eventually have disease progression during targeted therapy. Trastuzumab emtansine (T–DM1) is a novel ADC that combines the humanized antibody trastuzumab and the potent antimicrotubule agent T-DM1 (derivative of maytansine) using a unique and highly stable linker. The potential of maytansine was found in the 1970s with clinical responses noted against breast cancer; however, substantial toxicity prohibited further development. DM1 possesses in vitro cytotoxicity 10 to 200 times greater than that of taxanes and vinca alkaloids. A phase I trial of T-DM1 for patients with heavily pretreated HER2-positive breast cancer determined a recommended dose of 3.6 mg per kilogram delivered every 3 weeks. Responses were seen in multiple patients. T-DM1 was then studied in phase II trials of patients with HER2-positive metastatic breast cancer. In a studies of 112 and 110 patients in whom disease had progressed during HER2-directed therapy, T-DM1 was associated with objective response rates of 26% and 34%, respectively. The agent was well tolerated in both trials, with most toxicities being grade 1 and 2, and no bleeding episodes or cardiac events occurring. Additional phase II and III trials are now evaluating T-DM1 in the first-line setting. In one such trial, T-DM1 was compared with standard dosing of trastuzumab every 3 weeks plus docetaxel every 3 weeks. Objective response rates were comparable and grade 3 or4 adverse events were substantially reduced in the T-DM1 arm. The anticipated selective activity and reduction in side effects were thus noted. Randomized multicenter phase III trials are ongoing, including the EMILIA trial, an open-label trial of T-DM1 compared with the U.S. Food & Drug Administration-approved regimen of capecitabine plus lapatinib. The results of studies completed to date suggest T-DM1 is active in patients who have cancer resistant to trastuzumab-based combinations.
The Future of Oncology Care with Personal Health Records
Authors: Feldman Henry , Rodriguez Elizabeth S. 
Published: February 2020

Overview: Personal health records (PHRs) and patients' access to their own clinical information through a patient portal are changing the patient-physician relationship. Historically, health care providers have been gatekeepers of patients' medical records. Now, these portals provide patients access to clinical information, electronic messaging with the clinical team, and appointment and billing information. This type of access supports patient empowerment by engaging patients in their own care. Patients desire online access to information. The health care industry, like any other, must respond to the needs of its consumers. Oncology practices face unique challenges to meeting this need because of the complex nature of medical records of patients with cancer. Health care providers worry about the consequences of patients receiving “bad news” online, thereby increasing patient anxiety. This anxiety may, in turn, increase providers' workload by creating additional calls or visits to the office. These valid concerns require careful consideration when implementing a PHR or patient portal into a practice. Providers will benefit from a clear understanding of actual compared with potential risks and benefits. Much of the concerns about the negative effect on providers' workload and the potential increase in patients' anxiety have not been borne out. On the other hand, the implementation strategy, governance structure, and end-user education are crucial components to ensuring success. Successful implementation of a PHR or patient portal affords the opportunity to improve patient satisfaction and increase efficiency in provider workflow. The possibility exists to improve patient outcomes by engaging the patient in decision making and follow through.
A New Direction for Pancreatic Cancer Treatment: FOLFIRINOX in Context
Authors: Kindler Hedy Lee 
Published: February 2020

Overview: Since 1996, the cornerstone of chemotherapy for advanced pancreatic cancer has been gemcitabine, which has a genuine, but modest effect on survival and quality of life. It has been remarkably difficult to improve on these outcomes. Many phase III studies of gemcitabine doublets have been uniformly negative, with the exception of a trial of gemctabine plus erlotinib, which provided only marginal benefit. In 2010, the FOLFIRINOX regimen (bolus and infusional 5-fluorouracil, irinotecan, and oxaliplatin) emerged as a major treatment advance for patients with metastatic pancreatic cancer. In a trial with 342 patients, FOLFIRINOX yielded a longer median overall survival (11.1 vs. 6.8 months, hazard ratio [HR] 0.57, p < 0.001), a superior progression-free survival (6.4 vs. 3.3 months, HR 0.47, p < 0.001), a higher objective response rate (31.6% vs. 9.4%, p < 0.001), and a significant increase in time until definitive deterioration in quality of life, compared with gemcitabine. FOLFIRINOX is also more cost-effective than gemcitabine. Because of higher rates of grade 3 to 4 neutropenia (46% vs. 21%), febrile neutropenia (5% vs. 1%), and diarrhea (13% vs. 2%) with FOLFIRINOX, vigilant patient selection, education, and monitoring are essential. Retrospective single-institution series confirm the substantial activity of FOLFIRINOX in metastatic, locally advanced, and previously-treated patients; demonstrate its safety in individuals with biliary stents; and elucidate how physicians routinely modify drug doses without clear evidence or guidelines. Ongoing and planned studies will prospectively evaluate FOLFIRINOX in the adjuvant, locally advanced, and borderline resectable settings, will add targeted agents to FOLFIRINOX, and will evaluate how to adjust doses to ameliorate toxicity.
Targeted Therapy in Sarcoma: Should We Be Lumpers or Splitters?
Authors: Riedel Richard F. , Maki Robert G. , Wagner Andrew J. 
Published: February 2020

Overview: The identification of KIT as a critical driver in the pathogenesis of GI stromal tumor (GIST), and its subsequent inhibition with imatinib, have resulted in tremendous efforts to identify other potential therapeutic targets for the heterogeneous group of diseases known as sarcomas. Because of the rarity of sarcoma and the often limited number of patients per individual sarcoma subtype, clinical trials to date have often utilized unselected patient populations including multiple subtypes. Although this strategy increases the ease with which a particular trial may accrue patients, statistically significant therapeutic responses across an unselected patient population are often limited. Furthermore, in the absence of biologic correlatives, the identification of significant activity and subsequent interpretation of clinical trial results utilizing targeted therapies for this patient population have been challenging. However, hints have emerged, on the basis of preclinical and clinical observations, to suggest that certain targeted therapeutic approaches are appropriate in select histologic subtypes. This brief review will highlight data supporting the use of targeted therapy in both unselected and selected sarcoma patient populations.