bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between the maternal diet and the maternal and infant gut microbiome: a systematic review
Authors: Maher Siofra E. , O’Brien Eileen C. , Moore Rebecca L. , Byrne David F. , Geraghty Aisling A. , Saldova Radka , Murphy Eileen F. , Van Sinderen Douwe , Cotter Paul D. , McAuliffe Fionnuala M. 
Published: March 2020

AbstractDuring pregnancy, changes occur to influence the maternal gut microbiome, and potentially the fetal microbiome. Diet has been shown to impact the gut microbiome. Little research has been conducted examining diet during pregnancy with respect to the gut microbiome. To meet inclusion criteria, dietary analyses must have been conducted as part of the primary aim. The primary outcome was the composition of the gut microbiome (infant or maternal), as assessed using culture-independent sequencing techniques. This review identified seven studies for inclusion, five examining the maternal gut microbiome and two examining the fetal gut microbiome. Microbial data were attained through analysis of stool samples by 16S ribosomal RNA gene-based microbiota assessment. Studies found an association between the maternal diet and gut microbiome. High-fat diets (% fat of total energy), fat-soluble vitamins (mg/d) and fibre (g/d) were the most significant nutrients associated with the gut microbiota composition of both neonates and mothers. High-fat diets were significantly associated with a reduction in microbial diversity. High-fat diets may reduce microbial diversity, while fibre intake may be positively associated with microbial diversity. The results of this review must be interpreted with caution. The number of studies was low, and the risk of observational bias and heterogeneity across the studies must be considered. However, these results show promise for dietary intervention and microbial manipulation in order to favour an increase of health-associated taxa in the gut of the mother and her offspring.
Huriella flakusii (Teloschistaceae, lichenized Ascomycota), a new species from the Colca Canyon region in Peru
Authors: Wilk Karina 
Published: March 2020

AbstractA new species, Huriella flakusii, is described from the arid region of the Colca Canyon in southern Peru, and is characterized by squamulose, orange thalli and abundant, crowded and aggregated, usually flexuous when compressed, reddish apothecia. The thalline cortex, proper margin and hypothecium are paraplectenchymatous. The ascospores are broadly ellipsoid, 10‒15 × 5.0‒9.5 µm, with rather thin septa, 2‒4 µm. Phylogenetic analyses of the DNA sequences of ITS, nuLSU and mrSSU rDNA markers revealed that the new species is nested within the Amundsenia-Squamulea subclade in the subfamily Xanthorioideae, and has a sister group relationship to Huriella loekoesiana from South Korea.
The Political Representation of Economic Interests
Authors: Elkjær Mads Andreas , Iversen Torben 
Published: March 2020

ABSTRACTRising inequality has caused concerns that democratic governments are no longer responding to majority demands, an argument the authors label thesubversion of democracy model(sdm). Thesdmcomes in two forms: one uses public opinion data to show that policies are strongly biased toward the preferences of the rich; the other uses macrolevel data to show that governments aren’t responding to rising inequality. This article critically reassesses thesdm, points to potential biases, and proposes solutions that suggest a different interpretation of the data, which the authors label therepresentative democracy model(rdm). After testing thesdmagainst therdmon public opinion data and on a new data set on fiscal policy, they find that middle-class power has remained remarkably strong over time, even as inequality has risen. The authors conclude that the rich have little influence on redistributive policies, and that the democratic state is apparently not increasingly constrained by global capital.
CONNECTING THE NORTHERN ANDES AND THE ATLANTIC. THE ROLE OF INLAND PORTS IN NEW GRANADA'S INTERREGIONAL TRADE (1770-1809)
Authors: Torres-Moreno James V. , Henao-Giraldo José L. 
Published: March 2020

ABSTRACTThis paper analyses the role of Mompox in New Granada's interregional trade during the late colonial period. It focuses on the value, structure and destination of exports of domestic goods from Mompox to markets on the Atlantic and the Andes. By unearthing unexplored sources, this paper provides evidence that will help to understand, indirectly, some issues such as the nature and timing of economic growth, the degree of regional specialisation and, above all, the role of inland ports in the economic geography of the viceroyalty. The paper contends, first, that the region experienced a boom–bust cycle during the late colonial period. The export of domestic goods doubled between 1770 and 1800 but subsequently collapsed during the 1802-1809 years. Second, evidence suggests that the region experienced a process of market deepening and widening. Trade flows, then, played a larger role in shaping the economic history of the region than previously thought.
Seminaries and Discipleship: Exploring Future Directions
Authors: Spencer Stephen 
Published: March 2020

AbstractTheological colleges and seminaries across the Anglican Communion are at a crossroads and this essay proposes a reorientation of their life towards serving the intentional discipleship of the whole people of God. This kind of change would affect the culture as well as the content of what they do. For example, their pedagogy could become that of ‘the flipped classroom’, where ordinands engage in an apprenticeship style of learning, with their time in college falling within placement learning and providing constructive theological reflection upon that prior learning. This will bring great benefits to these institutions through their becoming re-connected and re-embedded in the life of the church at grass roots level, giving them a valued and indispensable role in the mission of the church in diverse contexts.
Differential Magnetometer Measurements of Geomagnetically Induced Currents in a Complex High Voltage Network
Authors: Hübert J. , Beggan C. D. , Richardson G. S. , Martyn T. , Thomson A. W. P. 
Published: March 2020

AbstractSpace weather poses a hazard to grounded electrical infrastructure such as high voltage (HV) transformers, through the induction of geomagnetically induced currents (GICs). Modeling GICs requires knowledge of the source magnetic field and the Earth's electrical conductivity structure, in order to calculate the geoelectric fields generated during magnetic storms, as well as knowledge of the topology of the HV network. Direct measurement of GICs at the ground neutral in substations is possible with a Hall effect probe, but such data are not widely available. To validate our HV network model, we use the differential magnetometer method (DMM) to measure GICs in the 400 kV grid of Great Britain. We present DMM measurements for the 26 August 2018 storm at a site in eastern Scotland with up to 20 A recorded. The line GIC correlates well with Hall probe measurements at a local transformer, though they differ in amplitude by an order of magnitude (a maximum of
2 A). We deployed a long‐period magnetotelluric (MT) instrument to derive the local impedance tensor which can be used to predict the geoelectric field from the recorded magnetic field. Using the MT‐derived electric field estimates, we model GICs within the network, accounting for the difference in magnitude between the DMM‐measured line currents and earth currents at the local substation. We find that the measured line and earth GICs match the expected GICs from our network model, confirming that detailed knowledge of the complex network topology and its resistance parameters is essential for accurately computing GICs.
D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration
Authors: Wang Bowen , Wang Li , Gu Sijie , Yu Yankun , Huang Huaxing , Mo Kunlun , Xu He , Zeng Fanzhu , Xiao Yichen , Peng Lulu , Liu Chunqiao , Cao Nan , Liu Yizhi , Yuan Jin , Ouyang Hong 
Published: March 2020

AbstractAccumulated oxidative damage may lead to irreversible retinal pigmented epithelium (RPE) cell death, which is considered to be the primary cause of dry age-related macular degeneration (AMD), leading to blindness in the elderly. However, an effective therapy for this disease is lacking. Here, we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate (SI)-induced oxidative cell death and prolonged their healthy survival. D609 effectively attenuated excessive reactive oxygen species (ROS) and prevented severe mitochondrial loss due to oxidative stress in the RPE cells. Surprisingly, the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of metallothionein. The injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse model. These findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609, which may ultimately have clinical applications for the treatment of AMD.
Spatiotemporal dynamics of the archaeal community in coastal sediments: assembly process and co-occurrence relationship
Authors: Liu Jiwen , Zhu Shangqing , Liu Xiaoyue , Yao Peng , Ge Tiantian , Zhang Xiao-Hua 
Published: March 2020

Abstract
Studies of marine benthic archaeal communities are updating our view of their taxonomic composition and metabolic versatility. However, large knowledge gaps remain with regard to community assembly processes and inter taxa associations. Here, using 16S rRNA gene amplicon sequencing and qPCR, we investigated the spatiotemporal dynamics, assembly processes, and co-occurrence relationships of the archaeal community in 58 surface sediment samples collected in both summer and winter from across ∼1500 km of the eastern Chinese marginal seas. Clear patterns in spatiotemporal dynamics in the archaeal community structure were observed, with a more pronounced spatial rather than seasonal variation. Accompanying the geographic variation was a significant distance-decay pattern with varying contributions from different archaeal clades, determined by their relative abundance. In both seasons, dispersal limitation was the most important process, explaining ∼40% of the community variation, followed by homogeneous selection and ecological drift, that made an approximately equal contribution (∼30%). This meant that stochasticity rather than determinism had a greater impact on the archaeal community assembly. Furthermore, we observed seasonality in archaeal co-occurrence patterns: closer inter-taxa connections in winter than in summer, and unmatched geographic patterns between community composition and co-occurrence relationship. These results demonstrate that the benthic archaeal community was assembled under a seasonal-consistent mechanism but the co-occurrence relationships changed over the seasons, indicating complex archaeal dynamic patterns in coastal sediments of the eastern Chinese marginal seas.
The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm
Authors: Ramat Anne , Garcia-Silva Maria-Rosa , Jahan Camille , Naït-Saïdi Rima , Dufourt Jérémy , Garret Céline , Chartier Aymeric , Cremaschi Julie , Patel Vipul , Decourcelle Mathilde , Bastide Amandine , Juge François , Simonelig Martine 
Published: March 2020

AbstractPiwi-interacting RNAs (piRNAs) and PIWI proteins are essential in germ cells to repress transposons and regulate mRNAs. InDrosophila, piRNAs bound to the PIWI protein Aubergine (Aub) are transferred maternally to the embryo and regulate maternal mRNA stability through two opposite roles. They target mRNAs by incomplete base pairing, leading to their destabilization in the soma and stabilization in the germ plasm. Here, we report a function of Aub in translation. Aub is required for translational activation ofnanosmRNA, a key determinant of the germ plasm. Aub physically interacts with the poly(A)-binding protein (PABP) and the translation initiation factor eIF3. Polysome gradient profiling reveals the role of Aub at the initiation step of translation. In the germ plasm, PABP and eIF3d assemble in foci that surround Aub-containing germ granules, and Aub acts with eIF3d to promotenanostranslation. These results identify translational activation as a new mode of mRNA regulation by Aub, highlighting the versatility of PIWI proteins in mRNA regulation.
Enhancing multiphoton upconversion through interfacial energy transfer in multilayered nanoparticles
Authors: Zhou Bin , Tang Bing , Zhang Chuang , Qin Changyun , Gu Zhanjun , Ma Ying , Zhai Tianyou , Yao Jiannian 
Published: March 2020

AbstractPhoton upconversion in lanthanide-doped upconversion nanoparticles offers a wide variety of applications including deep-tissue biophotonics. However, the upconversion luminescence and efficiency, especially involving multiple photons, is still limited by the concentration quenching effect. Here, we demonstrate a multilayered core-shell-shell structure for lanthanide doped NaYF4, where Er3+ activators and Yb3+ sensitizers are spatially separated, which can enhance the multiphoton emission from Er3+ by 100-fold compared with the multiphoton emission from canonical core-shell nanocrystals. This difference is due to the excitation energy transfer at the interface between activator core and sensitizer shell being unexpectedly efficient, as revealed by the structural and temperature dependence of the multiphoton upconversion luminescence. Therefore, the concentration quenching is suppressed via alleviation of cross-relaxation between the activator and the sensitizer, resulting in a high quantum yield of up to 6.34% for this layered structure. These findings will enable versatile design of multiphoton upconverting nanoparticles overcoming the conventional limitation.
Effects of chronic low-dose radiation on cataract prevalence and characterization in wild boar (Sus scrofa) from Fukushima, Japan
Authors: Pederson Samantha L. , Li Puma Margaret C. , Hayes Joshua M. , Okuda Kei , Reilly Christopher M. , Beasley James C. , Li Puma Lance C. , Hinton Thomas G. , Johnson Thomas E. , Freeman Kate S. 
Published: March 2020

AbstractThis study evaluated cataracts in wild boar exposed to chronic low-dose radiation. We examined wild boar from within and outside the Fukushima Exclusion Zone for nuclear, cortical, and posterior subcapsular (PSC) cataracts in vivo and photographically. Plausible upper-bound, lifetime radiation dose for each boar was estimated from radioactivity levels in each animal’s home range combined with tissue concentrations of 134+137Cesium. Fifteen exposed and twenty control boar were evaluated. There were no significant differences in overall prevalence or score for cortical or PSC cataracts between exposed and control animals. Nuclear (centrally located) cataracts were significantly more prevalent in exposed boar (p < 0.05) and had statistically higher median scores. Plausible upper-bound, lifetime radiation dose ranged from 1 to 1,600 mGy in exposed animals, with no correlation between dose and cortical or PSC score. While radiation dose and nuclear score were positively associated, the impact of age could not be completely separated from the relationship. Additionally, the clinical significance of even the highest scoring nuclear cataract was negligible. Based on the population sampled, wild boar in the Fukushima Exclusion Zone do not have a significantly higher prevalence or risk of cortical or PSC cataracts compared to control animals.
Absolute Structure from Scanning Electron Microscopy
Authors: Burkhardt Ulrich , Borrmann Horst , Moll Philip , Schmidt Marcus , Grin Yuri , Winkelmann Aimo 
Published: March 2020

AbstractThe absence of centrosymmetry in chiral and polar crystal structures is the reason for many technical relevant physical properties like optical birefringence or ferroelectricity. Other chirality related properties that are actually intensively investigated are unconventional superconductivity or unusual magnetic ordering like skyrmions in materials with B20 structure. Despite the often close crystal structure - property relation, its detection is often challenging due to superposition of domains with different absolute structure e.g. chirality. Our investigations of high quality CoSi crystals with B20 structure by both complementary methods X- ray (volume sensitive) and electron backscatter diffraction (EBSD) (surface sensitive) results the consistent assignment of the chirality and reveal fundamental differences in their sensitivity to chirality. The analysis of the surface of a CoSi crystal with domains of different chirality show the high spatial resolution of this method which opens the possibility to analyze the chirality in microstructures of technical relevant materials like thin films and catalysts.
Extracellular vesicle-miRNAs as liquid biopsy biomarkers for disease identification and prognosis in metastatic colorectal cancer patients
Authors: de Miguel Pérez Diego , Rodriguez Martínez Alba , Ortigosa Palomo Alba , Delgado Ureña Mayte , Garcia Puche Jose Luis , Robles Remacho Agustín , Exposito Hernandez José , Lorente Acosta Jose Antonio , Ortega Sánchez Francisco Gabriel , Serrano Ma Jose 
Published: March 2020

AbstractDisseminated disease is present in ≈50% of colorectal cancer patients upon diagnosis, being responsible for most of cancer deaths. Addition of biological drugs, as Bevacizumab, to chemotherapy, has increased progression free survival and overall survival of metastatic colorectal cancer (mCRC) patients. However, these benefits have been only reported in a small proportion of patients. To date, there are not biomarkers that could explain the heterogeneity of this disease and would help in treatment selection. Recent findings demonstrated that microRNAs (miRNAs) play an important role in cancer and they can be encapsulated with high stability into extracellular vesicles (EVs) that are released in biological fluids. EVs can act as cell-to-cell communicators, transferring genetic information, such as miRNAs. In this context, we aimed to investigate serum EV associated miRNAs (EV-miRNAs) as novel non-invasive biomarkers for the diagnosis and prognosis of Bevacizumab-treated mCRC patients. We observed that baseline miRNA-21 and 92a outperformed carcinoembryonic antigen levels in the diagnosis of our 44 mCRC patients, compared to 17 healthy volunteers. In addition, patients who died presented higher levels of miRNA-92a and 222 at 24 weeks. However, in the multivariate Cox analysis, higher levels of miRNA-222 at 24 weeks were associated with lower overall survival. Altogether, these data indicate that EV-miRNAs have a strong potential as liquid biopsy biomarkers for the identification and prognosis of mCRC.
High-throughput method for Antibiotic Susceptibility Testing based on Fluorescein Quenching by Bacteria: Application to Urinary Tract Infection
Authors: Radhakrishnan Rohit , J. Rajesh , N. S. Dinesh , C. P. Thangavelu , K. Sankaran 
Published: March 2020

AbstractWe recently reported a sugar-induced bacterial release of 13-Docosenamide and its ability to quench fluorescein. This simple handle to monitor bacterial growth is readily applicable to develop a quicker antibiotic sensitivity testing method along with a low-cost field-use optical instrumentation. Conditions were standardized to perform this new procedure in the most preferred and CLSI-recommended microdilution format in 12-well strips. A simple and portable optoelectronic prototype was used to capture the image and read the fluorescence signal of the culture medium of the 12-well strips. This new Fluorescence Quenching Method along with the device enabled the choice of the right antibiotic within 8 h of sample collection from the patient. It was compliant to the Clinical Laboratory Standard Institute’s quality control guidelines. Clinical assessment of the method using 440 urine samples from Urinary Tract Infection patients against 21 routinely used antibiotics showed a 94.3% match with the results of the Standard Disk Diffusion method. This new method saves the precious time taken for and the cost of antibiotic susceptibility testing for quicker and effective treatment with better compliance.
Dynamic changes of facial skeletal fractures with time
Authors: Yu Bao-Hai , Han Shu-Man , Sun Tao , Guo Zhe , Cao Lei , Wu Hui-Zhao , Shi Yun-Heng , Wen Jin-Xu , Wu Wen-Juan , Gao Bu-Lang 
Published: March 2020

AbstractTo investigate the characteristics of imaging changes with time of facial fractures, patients with facial fractures who had computed tomographic scan were enrolled including 500 patients who were divided into six groups based on the time of scanning: super early (<3 d), early (4–7 d), early-to-medium (8–14 d), medium (15–21d), medium-to-late (22d–2 months) and late stage (>2 months). The data were compared and analyzed. Forty two patients with frontal bone fractures had high-energy impact as the reason of fractures. The fracture line was clear and sharp within one week but blunt and sclerotic due to bone absorption at 2–3 weeks, and might exist for a long time. All patients had soft tissue swelling and paranasal sinus effusion at 1–2 weeks after injury. Air might gather in the adjacent soft tissues and/or intracranially within 3 days of injury if the fracture involved the frontal or other sinuses. Twelve of the 42 patients (28.6%) had intracranial hematoma, and five (11.9%) had epidural effusion. Subarachnoid hemorrhage was mostly absorbed within one week while epidural hematoma was completely absorbed over 3 weeks. Significant changes (P < 0.05) in the fracture lines, effusion of paranasal sinuses, soft tissue swelling and pneumocephalus were observed during the study period. For patients with medial orbital wall fractures, the fracture line was sharp and clear at early stages with concurrent sphenoid sinus effusion, and the fracture line became depressed 3 weeks later with disappearance of sphenoid sinus effusion. Significant changes (P < 0.05) were observed in the sharp fracture line, soft tissue swelling, sphenoid sinus effusion and smooth depression at fracture sites. For nasal fractures, the fracture line was sharp and clear at early stages with concurrent soft tissue swelling which disappeared one week later. The fracture line became smooth three weeks later. A significant (P < 0.05) difference was demonstrated in the changes of fracture line and soft tissue swelling with time. In conclusion, facial fractures have some dynamic alterations with time and identification of these characteristics may help reaching a correct clinical diagnosis with regard to fracture severity and time.