bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperament and character of patients with alcohol toxicity during COVID -19 pandemic
Authors: Estedlal AliReza , Mani Arash , Vardanjani Hossein Molavi , Kamali Mahsa , Zarei Leila , Heydari Seyed Taghi , Lankarani Kamran B 
Published: July 2020

Abstract
Background
Corona virus pandemic acts as a stressor or trauma that affects both physical health and mental health. People exhibited various reactive behaviors to confront with this stressful situation. Alcohol consumption for coping motive was one of the most common techniques. Personality factors evidently influence alcohol consumption, since they are associated with drinking motives. The main purpose of this study is to investigate the correlation between temperament and character and alcohol abuse.
Methods
This cross-section study was conducted on 135 alcohol toxicity patients admitted to emergency room in March 2020 and 255 participants who were randomly selected from public in Shiraz. The questionnaire consisted of TCI (Temperament and character inventory) and several questions about COVID-19 pandemic. It was completed by a trained interviewer using the matched answer technique. Demographic factors were also self-reported.
Results
Among the participants, 216 were males (55.4%) and 174 females (44.6%). The mean age of the participants was 32.88 ± 13.49 years. Alcohol toxicity was mostly observed among the young males (male/female ratio was 6.45). Mean scores of novelty seeking, harm avoidant, and self-transcendent were higher in the alcohol toxicity group than normal population (P < 0.01). Mean scores of reward dependent, cooperativeness, and self-directedness were higher in normal population than the alcohol toxicity group (P < 0.001). The mean score of persistence was not significant in both group (P = 0.718).
Conclusion
Novelty-seeking and self-transcendence scores were higher and reward-dependency score was lower among the alcohol abusers and cooperativeness and self-directedness scores were lower among the alcohol abusers. Higher novelty-seeking was correlated with higher impulsiveness, exploratory excitability, extravagance, and disorderliness, which are included in Cluster B personality disorders and associated with alcohol and drug involvement. Lower self-directedness and lower cooperativeness indicate the higher likelihood of personality disorders. Cluster A personality disorder symptoms (in particular, schizoid personality disorder symptoms) are correlated with low reward-dependence scores.
Is there any difference in the fractional amplitude of low-frequency fluctuations between first episode major depressive disorder patients and subclinical depressive subjects?
Authors: Xie Fang , Ruan Xiuhang , Zhang Guoqing , Li Yuting , Li E , Cheng Xiaofang , Du YUcheng , Jiang Xinqing , Zhang Lulu , Wei xinhua 
Published: July 2020

Abstract
Background

To explore the differences in the fractional amplitude of low-frequency fluctuations (fALFF) at the whole-brain level between young adults with major depressive disorder (MDD) and those with Subclinical depression (SD).
Methods

Thirty-nine first-episode MDD patients, 30 SD subjects, and 37 healthy controls (HCs) were recruited. All participants underwent resting-state fMRI (Rs-fMRI) scans on a 3T MR scanner. We used the fALFF to explore spontaneous neuronal activity between groups.
Results

Significant differences in the fALFF were observed among the three groups. Compared with the HCs, an increased fALFF was found in the left cerebellum in MDD patients. When MDD patients were compared with SD subjects, we observed increased fALFF values in the bilateral fusiform gyrus and decreased fALFF values in the right inferior frontal gyrus, right superior frontal gyrus, right middle frontal gyrus, left cuneus and right precuneus. Compared with the HCs, the SD group demonstrated increased fALFF values in the precuneus. Additionally, a positive correlated was revealed between the fALFF values and Hamilton Anxiety Scale (HAMA)score in the right fusiform gyrus in MDD patients. Moreover, the fALFF value were negatively correlated with the Beck Depression Inventory (BDI) score in the right inferior frontal gyrus and with the age in the left fusiform gyrus in SD subjects.
Conclusions

Our findings suggest that alterations of cognitive and executive networks, default mode networks and visual recognition circuits may contribute to the different neural mechanisms between MDD and SD in young adult subjects.
Cloning and Functional Analysis of pqq Genes Phosphorus Solubilizing From Bacillus Mycoides Gnyt1
Authors: xiaomei yang , Yao Tuo 
Published: July 2020

Abstract
[Background]The pqq genes which encodes phosphorus solubilizing from Bacillus mycoides Gnyt1 has been cloned and characterized. The role of this action on the function of pqq genes were detected. The phosphorus soluble pqq genes can secrete some specific organic activity acids to work but don’t destroy the living environment of plants such as soil. In contrast, this plants containing the pqq genes grew well, even better than other plants with lower phosphorus solubilization, in the phosphorus free medium even though its pqq genes activity and turned out phosphorus ring, while pqq dependent expression was induced.[Results]This reaserch that five pqq genes were cloned from Bacillus mycoides Gnyt1, phylogenetic analysis revealed that pBI-pqqA, pBI-pqqB, pBI-pqqC and pBI-pqqE similarly cluster with Phosphorus-soluble protein. Under the action of five promoters, each coding region of pqqA, pqqB, pqqC and pqqE from Bacillus mycoides Gnyt1 can directly participate in the phosphate solubilization of the strain, directly improving the phosphate solubilizing capacity of the plant, which have strong nitrogenase activity. Interestingly, changes in the phosphate solubilizing gene result in complete loss of the phosphate solubilization of the strain. However, the ability to dissolve the phosphorus ring and to dissolve the phosphorus was also exhibited in the medium having five phosphorus-dissolving genes.[Conclusions]The results indicated that the pqq genes were successfully cloned and a new specific phosphate-dissolving strain was formed. In this research, pqq genes were first cloned from Bacillus mycoides Gnyt1.
Evaluating the long-term efficacy and effectiveness of Viscocanalostomy and combined phacoemulsification with Viscocanalostomy in the treatment of patients with uveitic glaucoma: 5-year follow up data
Authors: Salloukh Adonis El , Ansari Abdus Samad , Chiu Alexander , Mathews Divya 
Published: July 2020

Abstract
Background
Uveitic glaucoma commonly leads to more intense optic nerve damage than other types of glaucoma, causing glaucomatous optic nerves and visual field defects. Anterior uveitis is the most commonly associated risk factor. Surgical intervention is usually indicated when all medical treatment has failed. We report five-year results for 16 eyes of uveitic glaucoma managed with viscocanalostomy (VC)/Phaco viscocanalostomy (PVC).
Methods
Retrospective analysis on all uveitic glaucoma cases meeting a five-year follow was completed. All patients were managed surgically with either viscocanalostomy (VC) or phacoviscocanalostomy (PVC). Outcomes evaluated included intraocular pressures measurement pre-listing, on day 1, year 1 to year 5. Complete success rate was defined as achieving an intraocular pressure (IOP) lower than 21 mmHg or reduced by 30% without medications, and qualified success was achieved when IOP was lower than 21 mmHg or a reduction in IOP of 30% with topical medical therapy ± Laser goniopinture (LGP). If further surgeries were required to reduce IOP due to glaucoma progression then they were classed as a failure.
Results
A total of 16 patients with uveitic glaucoma were reviewed. Complete Success was seen in 75% of patients at year 1, 50% of patients at year 3 and 19% of patients in year 5. Conversely qualified success was achieved in 94% of patients at year 1, 86% of patients at year 3 and 75% of patients at year 5. In the group of patients requiring further surgery, 50% of patients had previous surgeries, including cataract surgery, trabeculectomy and viscocanalostomy. There was a mean number of 4 pre-operative drops before their primary surgery and a mean drop in eye medications of 1.1 at 5 years follow-up. Success rates were prognostically linked to lower mean number of interventions and lower percentage of previous surgeries.
Conclusion
There remains a significant paucity of information in the utilization of PVC in uveitic glaucoma. The advantage of nonpenetrating glaucoma surgery (NPGS) includes the lack of entry into the anterior chamber and the avoidance of an iridectomy which may reduce intraocular inflammation and postoperative complications. Our study shows that non-penetrating surgery is successful in treating advanced uveitic glaucoma.
A retrospective case series of Fournier’s gangrene: necrotic fasciitis in perineum and crissum
Authors: Zhang Nan , Yu Xin , Zhang Kai , Liu Tongjun 
Published: July 2020

Abstract
BackgroundTo describe the clinical characteristics and management for Fournier’s gangrene. Experience summary and literature references are provided for future treatment improvement.MethodsWe retrospectively reviewed the cases diagnosed with Fournier’s gangrene in our department from June 2016 to June 2019. Clinical data, including manifestation, diagnosis, treatment and outcomes for Fournier’s gangrene were presented.ResultsThere were 12 patients enrolled in this paper, with the average age of 60 years old. It showed a male predominance with male-to-female ratio of 6:1. The average of LRINEC score of 10.1. Diabetes mellitus was the main predisposing disease. 11 patients received emergency debridement and 1 patient died of sepsis on the 2nd day after admission. The mortality rate was 8.3%. 6 cases developed complications, including sepsis, pneumonia, renal and heart failure. NPWT was applied in 10 cases, while the rest 1 received normal daily dressing changes because of fecal contamination. Flaps were utilized in 2 patients to cover the defect, including one with advancement flap and one with pudendal-thigh flap, while others received secondary suture, secondary healing, skin graft or combined management. No relapse was observed during the follow-up visits.ConclusionsFournier’s gangrene is a life-threatening infection that requires early diagnosis and surgery intervention. The predisposing disease, clinical manifestation and LRINEC score should be taken into comprehensive consideration, which is helpful for timely diagnosis. Moreover, further successful treatment depends on the aggressive debridement, broad-spectrum antibiotics therapy, wound management and closure choice.
Transcriptome Research of Key Modules and Hub Genes Associated with Primary Myelofibrosis by Weighted Co-expression Network Analysis.
Authors: Li Weihang , Yuan Bin , Zhang Shilei , Ding Ziyi , Zhao Yingjing , Zhong Sheng , Gao Guangxun , Yan Ming 
Published: July 2020

Abstract
Background: This study aimed to identify novel targets of diagnosis, therapy as well as prognosis for primary myelofibrosis (PMF).Methods: The gene expression profiles of GSE26049 was obtained from GEO dataset, weighted gene co-expression network analysis (WGCNA) was then performed to identify the most related modules with PMF. Subsequently, GO (Gene Ontology), KEGG (Kyoto Encyclopedia Genes and Genomes), GSEA (Gene Set Enrichment Analysis) and PPI (Protein-Protein Interaction) network were conducted to fully understand the detailed information of the green module.Results: Green module was strongly correlated with PMF disease after WGCNA analysis. 20 genes in green module were identified as hub genes responsible for the progression of PMF. Functional annotation and pathway analysis revealed that these hub genes were primarily enriched in erythrocyte differentiation, transcription factor binding, hemoglobin complex, transcription factor complex and cell cycle et al. Of which, EPB42, CALR, SLC4A1 and MPL had the most correlations with PMF.Conclusions: This study elucidated that genes EPB42, CALR, SLC4A1 and MPL were significantly more highly expressed in PMF samples than in normal samples. These four genes may be considered candidate prognostic biomarkers and potential therapeutic targets for early stage of PMF. Meanwhile, EPB42 and SLC4A1 were firstly found to be highly correlated with the progression of PMF.
Insight of Transcriptional Regulators reveals the Tolerance Mechanism of Carpet-grass (Axonopus compressus) Against Drought
Authors: Nawaz Mohsin , Li Liao , Azeem Farrukh , Shabbir Samina , Zohaib Ali , Ashraf Umair , Wang Zhiyong , Hubiao Yang 
Published: July 2020

Abstract
Highlights:1. Axonopus compressus can stand severe drought stress by activating the potential defense mechanism.2. We investigated the differential transcriptome of drought stressed and normal Axonopus compressus plants3. New comers have been identified that involved in the drought response4. Identified drought responsive genes which never known for other stresses.5. The identified genes also respond to stress in Arabidopsis thaliana in different manners.Background: Carpet grass [Axonopus compressus (L.)] is an important warm season perennial grass around the world and is renowned for its adaptability to varied environmental conditions. However, Carpet grass lacks enough data in public data bank, which confined our comprehension of the mechanism of environmental adaptations, gene discovery and development of molecular marker. Methods: In current study, the DEGs (differentially expressed genes) in Axonopus compressus under drought stress (DS) were identified and compared with CK (control) by RNA-Seq. Results: the 263,835 of total unigenes were identified in Axonopus compressus, and 201,303 (also add the numbers of remaining2 data bases) a sequence of unigenes significantly matched in at least one of the seven databases. A total of 153697 (58.25%) unigenes can be classified to 144 KEGG pathways, and 7,444 unigenes were expressed differentially between DS and CK, of which 4,249 were up-regulated and 3,195 were down-regulated unigenes. Of the 50 significantly enriched GO terms, 18, 6 and 14 items were related to BP, CC and MF, respectively. Analysis of KEGG enrichment showed 2569 DEGs involved in 143 different pathways, under drought stress 2,747 DEGs were up-regulated and 2,502 DEGs were down-regulated. Moreover, we identified 352 transcriptor factors (TFs) in Axonopus compressus, of which 270 were differentially expressed between CK and DS. The qRT-PCR validation experiment also support the transcriptional response of Axonopus compressus against drought. Conclusions: The current findings provide the first framework for further investigation for the particular roles of these unigenes in Axonopus compressus in response to droughts.
Gene Expression Patterns Associated with Tumor-Infiltrating CD4+ and CD8+ T Cells in Invasive Breast Carcinomas
Authors: Wang zhanwei , Xu Jiamin , Yang Xi , Pan Yuefen , Shen Junjun , Liu Jin , Han Shuwen 
Published: July 2020

Abstract
Objective: This study investigated the gene expression patterns associated with tumor-infiltrating CD4+ and CD8+ T cells in invasive breast carcinomas.Methods: The gene expression data and corresponding clinical phenotype data from the Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) were downloaded. The stromal and immune score were calculated using ESTIMATE. The differentially expressed genes (DEGs) with a high vs. low stromal score and a high vs. low immune score were screened and then functionally enriched. The tumor-infiltrating immune cells were investigated using the Cibersort algorithm, and the CD4+ and CD8+ T cell-related genes were identified using a Spearman correlation test of infiltrating abundance with the DEGs. Moreover, the miRNA-mRNA pairs and lncRNA-miRNA pairs were predicted to construct the competing endogenous RNAs (ceRNA) network. Kaplan-Meier (K-M) survival curves were also plotted.Results: In total, 478 DEGs with a high vs. low stromal score and 796 DEGs with a high vs. low immune score were identified. In addition, 39 CD4+ T cell-related genes and 78 CD8+ T cell-related genes were identified; of these, 14 genes were significantly associated with the prognosis of BRCA patients. Moreover, for CD4+ T cell-related genes, the chr22-38_28785274-29006793.1-–miR-34a/c-5p–CAPN6 axis was identified from the ceRNA network, whereas the chr22-38_28785274-29006793.1–miR-494-3p–SLC9A7 axis was identified for CD8+ T cell-related genes.Conclusions: The chr22-38_28785274-29006793.1-–miR-34a/c-5p–CAPN6 axis and the chr22-38_28785274-29006793.1–miR-494-3p–SLC9A7 axis might regulate cellular activities associated with CD4+ and CD8+ T cell infiltration, respectively, in BRCA.
Ultrasound-Guided IV Placement by Emergency Department Nurses versus Hospital IV Insertion Team- A Retrospective Study of Time to Successful Insertion
Authors: LaBond Virginia , Josey Nicholaus , FACEP Roya Caloia D.O. M.P.H. , Hella Jennifer , Barber Kimberly 
Published: July 2020

Abstract
Background IV access in the emergency and acute care settings can often present as a challenge for patient care employees who are tasked with the essential task of placing an IV into a patient’s vein. This study compares time to IV placement by a IV Resource Insertion team compared to trained ER nurses in the skill of ultrasound guided.Methods This was a single site retrospective study which looked at the time to IV placement between a trained team of ER nurses and a formal IV insertion team, both using ultrasound guidance. The primary measure time to IV placement; age, gender, comorbidities and signs of infection were also reported.Results Thirty patients were chosen for each group. There was a statistically significant difference in times to IV placement between the ultrasound guided IV ER nurse team and the formal IV insertion team, with shorter times to IV insertion by the trained ER nurse team.Conclusion This study lends credibility to the notion that Emergency Department personal should be encouraged to learn and utilize US guided IV insertion to better improve patient waiting times for things such as lab results, IV fluids and antibiotics. This will improve patient experience and care. It will also help to decompress resource stressed health systems.
WITHDRAWN: Predictability of Blood Parameters on the Course of Covid-19- a retrospective clinical study
Authors: Çora Ahmet Rıfkı , Çelik Ersin 
Published: July 2020

Abstract
Background In December 2019, clusters of patients with pneumonia of an unkown cause were reported in Wuhan, Hubei Province in China. On january 2020, Chinese scientists identified this as a novel coronavirus, temporarily labelled as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although recent studies investigating predictors of poor prognosis at an early stage identified exact parameters as a predictor for the disease still controversial. Here we study biochemical and hematologic parameters of 197 patients diagnosed as Covid-19 at our hospital for evaluating the value of these biomarkers for predicting the course of Covid-19 disease.Material and Method197 patients who were diagnosed with Covid-19 at our hospital according to World Health Organisation (WHO) interim guidance were screened between march 2020-may 2020 retrospectiveley for the study. Patients selected from the population of service and intensive care unit (ICU). Biochemical and hematologic parameters retrospectively evaluated for predicting the course of Covid-19 disease.ResultsAmong 197 patient population of service and ICU, hematological and biochemical parameters studied. There was a significiant association found between the parameters neurtophile/lymphocyet ratio, white blood cell, eosynophile, monocyte, lymphocyte counts and high sensitive troponin-I levels and ICU admission. ConclusionWe found increased levels of neutrophile/lymphocyte ratio, white blood cell count and high sensitive troponin-I and decreased levels of eosynophile, monocyte and lymphocyte counts among ICU admitted patients. We concluded that these biochemical and hematologic parameters can be used for the predicting the course of Covid-19 disease.
A novel minimally invasive approach for chronic pancreatitis: combination of Frey procedure and laparoscopic distal pancreatectomy
Authors: Saito Kenta , Matsuo Yoichi , Ueda Goro , Omi Kan , Hayashi Yuichi , Imafuji Hiroyuki , Tsuboi Ken , Morimoto Mamoru , Ogawa Ryo , Takahashi Hiroki , Naitoh Itaru , Hayashi Kazuki , Kataoka Hiromi , Takiguchi Shuji 
Published: July 2020

Abstract
Background
The treatment of chronic pancreatitis requires a surgical approach in patients refractory to medical therapy. During surgical treatment, ductal decompression is required, but a pancreatectomy is necessary for some patients, such as those with severe stenosis of the pancreatic duct. Importantly, inadequate procedures lead to recurrent pancreatitis. We used a novel minimally invasive approach for patients with severe stenosis of the pancreatic duct. In this report, we aim to present the feasibility and outcomes of our approach.
Methods
We selected a laparoscopic approach for the distal pancreatectomy because these parts are relatively safe and the effect of reducing the length of the wound is substantial. We selected an open approach for parts of the Frey procedure because complete ductal compression has a high risk for injury to the vessels posterior to the pancreas. We examined operative outcomes, postoperative complications and recurrence of pancreatitis.
Results
Our approach was performed in three patients from January 2018 to December 2018. No intraoperative complications occurred and the postoperative course was uneventful in all patients. There were no recurrence of pancreatitis and no postoperative pain in all patients in the over 18 months follow-up.
Conclusion
Our hybrid method focusing on complete ductal compression with safety and minimal invasiveness is the optimal approach for the surgical treatment of chronic pancreatitis which requires a pancreatectomy with the Frey procedure.
Renal Oxygenation in male Metabolic Syndrome as evaluated by Blood Oxygen Level-Dependent Magnetic Resonance Imaging
Authors: Li Yongqiang , Zhang Xiaodong , Li Chijian , Li Shisi , Liang Shiyi , Guo YiHao , Qian Ge , Huang Yuxiang , Xv Weicheng 
Published: July 2020

Abstract
Background- Blood Oxygen Level-Dependent Magnetic Resonance Imaging (BOLD-MRI) provide regional measurements of oxygen content using deoxyhemoglobin paramagnetic characteristics. Metabolic Syndrome (MS) could affect renal oxygenation, which have an impact on the clinical course of the disease. The goal of this study was to evaluate BOLD-MRI findings in kidneys of male patients with MS.Materials and Methods- A total of 24 males patients with MS were collected in the hospital and 24 male volunteers were selected as the control group. All volunteers underwent a renal scan using 3.0T magnet (Philips, Achieva). R2* of the renal cortex and medulla was measured on BOLD images.Results- Medullary R2* (MR2*) and Medulla/Cortex R2* ratio（MCR） were significantly lower in MS patients (MR2*=24.39±2.18 s−1, MCR=1.29±0.14) than in controls (MR2*=28.21±4.70s−1, MCR=1.53±0.28 ) (P<0.01), and cortical R2* (CR2*) values were not significantly different between the two group. Conclusions- The MR2* and MCR were lower in male patients with MS compared to controls. MR2*and MCR were potential imaging biomarkers for prediction of early renal impairment in male MS.