bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clotting functional stability of withdrawing blood in storage for acute normovolemic hemodilution: a pilot study
Authors: Kinoshita Hirotaka , Saito Junichi , Nakai Kishiko , Noguchi Satoko , Takekawa Daiki , Tamai Yoshiko , Kitayama Masato , Hirota Kazuyoshi 
Published: September 2020

Abstract
Purpose
This study was conducted to time-course changes of clotting function of withdrawing blood for acute normovolemic hemodilution (ANH).

Methods
Twelve enrolled patients who underwent ANH from August, 2018 to January, 2019. Blood was withdrawn into blood collection pack and shaken at 60–80 rpm for 24 h in room temperature. Clot formation was evaluated using rotational thromboelastometry (ROTEM™) just after blood withdrawal (control) and 4, 8, 12 and 24 h after blood withdrawal. We compared with the control value and each value of extrinsically-activated test with tissue factor (EXTEM), intrinsically-activated test using ellagic acid (INTEM) and fibrin-based extrinsically activated test with tissue factor (FIBTEM).

Results
Maximum clot firmness (MCF) of FIBTEM did not change significantly. MCF of EXTEM was significantly decreased time-dependent manner but all MCF of EXTEM were within a normal range. Maximum percent change in MCF of EXTEM was 12.4% [95% confidence interval (CI): 9.0–15.8%]. The difference in the maximum clot elasticity (MCE) between EXTEM and FIBTEM (MCEEXTEM−MCEFIBTEM) was significantly decrease from 8 h after blood withdrawal. Maximum percent change in MCEEXTEM−MCEFIBTEM was 30.2% (95% CI:17.6–42.9%) at 24 h after blood withdrawal.

Conclusion
Even though the MCE significantly decreased in a time-dependent manner, MCF of FIBTEM and EXTEM was normal up to 24 h storage. The blood of ANH can use for the purpose of hemostasis at least 8 h stored at room temperature after blood withdrawal. Future studies are needed to elucidate the clinical impact on the patient after delayed transfusion of ANH blood with regard to patient’s hemostasis.
Quantitative Raman spectroscopy for the Ioncell® process: Part 2—quantification of ionic liquid degradation products and improvement of prediction performance through interval PLS
Authors: Guizani Chamseddine , Hellstén Sanna , Witos Joanna , Mäkelä Mikko , Hummel Michael , Sixta Herbert 
Published: September 2020

AbstractOne of the main issues associated with ionic liquids (ILs) is their recyclability. Viable recycling concepts can only be developed if one knows what is in the IL mixtures and solutions. In our previous work, we showed that it is possible to quantify water and 1.5-diazabicyclo[4.3.0]non-5-enium acetate [DBNH][OAc] IL components in liquid mixtures using Raman spectroscopy. In this regard, we considered Raman spectroscopy as a promising analytical method for the inline monitoring and control of the Ioncell® process. In the present work, we push the limits of this analytical method further by extending it to more complex and realistic liquid mixtures including the hydrolysis product 1-(3-aminopropyl)-2-pyrrolidone (APP) that can be formed upon the reaction of 5-diazabicyclo[4.3.0]non-5-ene (DBN) with water. Quantifying APP is important in order to measure the extent of the hydrolysis reaction and apply the right corrective measures to reverse the reaction and to maintain the process within the optimal working conditions. The simultaneous quantification of the four components (Acetic acid, DBN, APP and H2O) in typical Ioncell® liquid streams is investigated using Raman spectroscopy. The sensitivity of the Raman method in quantifying APP is also highlighted in comparison with refractometry, which is widely applied to measure IL concentration in aqueous mixtures. Finally, we propose simple modifications on the multivariate partial least square regression model based on a variable selection algorithm to enhance the accuracy of the predicted calibration values.
MISCELA: discovering simultaneous and time-delayed correlated attribute patterns
Authors: Harada Kei , Sasaki Yuya , Onizuka Makoto 
Published: September 2020

AbstractThis article addresses a new pattern mining problem in time series sensor data, which we call correlated attribute pattern mining. The correlated attribute patterns (CAPs for short) are the sets of attributes (e.g., temperature and traffic volume) on sensors that are spatially close to each other and temporally correlated in their measurements. Although the CAPs are useful to accurately analyze and understand spatio-temporal correlation between attributes, the existing mining methods are inefficient to discover CAPs because they extract unnecessary patterns. Therefore, we propose a mining method Miscela to efficiently discover CAPs. Miscela can discover not only simultaneous correlated patterns but also time delayed correlated patterns. Furthermore, we extend Miscela to automatically search for correlated patterns with any time delays. Through our experiments using three real sensor datasets, we show that the response time of Miscela is up to 20.84 times faster compared with the state-of-the-art method. We show that Miscela discovers meaningful patterns for urban managements and environmental studies.
Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus
Authors: Sardar Reza , Zandieh Zahra , Namjoo Zeinab , Soleimani Mansoureh , Shirazi Reza , Hami Javad 
Published: September 2020

AbstractBrain-derived neurotrophic factor (BDNF), as a member of neurotrophin family, plays an important role in neurogenesis, neuronal survival and synaptic plasticity. BDNF is strongly expressed in the hippocampus, where has been associated with memory consolidation, learning, and cognition. In this study, Real-time PCR, immunohistochemistry, and stereology were used to evaluate the gender differences and left-right asymmetries in the expression of BDNF in the developing rat hippocampus during the neurogenesis-active period, at postnatal days P0, P7 and P14. We found the lowest expression of BDNF in the right side and the highest in the left side hippocampi of both male and female neonates at P14 (P ≤ 0.05 each). At the same time, there were significant differences in the hippocampal expression of BDNF between males and females (P ≤ 0.05 each). No important differences in the number of BDNF expressing neurons in different subregions of right/left hippocampus were observed between male and female animals at P0 and P7 (P > 0.05). Furthermore, the highest numerical density of BDNF positive cells was detected in the both sides hippocampal CA1 in the male/female offspring at P7, and in the CA2, CA3 and dentate gyrus at P14 (P ≤ 0.05 each). Based on these findings, it can be concluded that there are prominent sex and interhemispheric differences in the expression of BDNF in the developing rat hippocampus, suggesting a probable mechanism for the control of gender and laterality differences in development, structure, and function of the hippocampus.
Immunity to wh-misidentification
Authors: McGlynn Aidan 
Published: September 2020

AbstractThis paper responds to arguments due to Joel Smith and Annalisa Coliva that try to show that James Pryor’s notion of wh-misidentification is philosophically uninteresting, and perhaps even spurious. It also proposes definitions of wh-misidentification and immunity to wh-misidentification which try to improve in various ways on the characterisations that standardly figure in the literature, and explores the relationship between misidentification and the epistemic structures characteristic of some kinds of Gettier cases.
Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration
Authors: Michalik Marcin , Gładyś Aleksandra , Czekaj Piotr 
Published: September 2020

AbstractToxic, viral and surgical injuries can pose medical indications for liver transplantation. The number of patients waiting for a liver transplant still increases, but the number of organ donors is insufficient. Hepatocyte transplantation was suggested as a promising alternative to liver transplantation, however, this method has some significant limitations. Currently, afterbirth tissues seem to be an interesting source of cells for the regenerative medicine, because of their unique biological and immunological properties. It has been proven in experimental animal models, that the native stem cells, and to a greater extent, hepatocyte-like cells derived from them and transplanted, can accelerate regenerative processes and restore organ functioning. The effective protocol for obtaining functional mature hepatocytes in vitro is still not defined, but some studies resulted in obtaining functionally active hepatocyte-like cells. In this review, we focused on human stem cells isolated from placenta and umbilical cord, as potent precursors of hepatocyte-like cells for regenerative medicine. We summarized the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy. It was concluded that the use of native afterbirth epithelial and mesenchymal cells in the treatment of liver failure could support liver function and regeneration. This effect would be enhanced by the use of hepatocyte-like cells obtained from placental and/or umbilical stem cells.
Adaptivität im Sportunterricht in selbstständigen Arbeitsphasen messen
Authors: Wibowo Jonas 
Published: September 2020

ZusammenfassungAdaptives Unterrichten wird als ein vielversprechender Ansatz gesehen, um mit der großen interindividuellen Vielfalt unter den Schüler*innen im Sportunterricht umzugehen. Die Bedeutung der Thematik ergibt sich einerseits aus der gleichstellungspolitischen Forderung einer individuellen Förderung, aber auch aus einer lern- und bildungstheoretischen Notwendigkeit, Lernumgebungen an individuelle Bedürfnisse anzupassen, um Lern- und Bildungsprozesse zu unterstützen. Dabei gilt die Passung zwischen der Instruktion der Lehrperson und den Voraussetzungen der Schüler*innen als zentrales Gütekriterium für den Umgang mit Heterogenität. Die Forschungslandschaft zu der Thematik ist durch eine enorme Vielfalt in Bezug auf die Auslegung von und den forschungsmethodischen Zugang zu adaptivem Unterrichten geprägt. In dem Beitrag werden ein Ansatz zur standardisierten Beobachtung der Passung zwischen der lehrpersonseitigen Instruktion und den Lernaktivitäten der Schüler*innen sowie Ergebnisse einer Pilotierungsstudie vorgestellt. Passung (Contingency) wird dabei als Verhältnis von Instruktionen zu vorangegangen Lernaktivitäten operationalisiert. Die Ergebnisse der Pilotierung deuten darauf hin, dass das Kodierverfahren zuverlässig ist (Cohen’s Kappa: 0,7–0,96) und im beobachteten Unterricht der sechs Lehrpersonen Contingency bei bestimmten Lernaktivitäten (niedrige Autonomie) eher auftritt als bei anderen (hohe Autonomie).
Identification of Pavement Model Parameters in the Area of Discontinuous Surface Deformation Based on FWD Tests
Authors: Grygierek Marcin , J. Sternik Krzysztof 
Published: September 2020

AbstractDetermination of the parameters of the pavement model in the linear discontinuous surface deformation (LDSD) area is presented in the article. The values are based on back calculations which involve results obtained from the elastic half-space model and the elastic—perfectly plastic model implemented in the finite element code compared with the results of the pavement deflection measured with Falling Weight Deflectometer (FWD). Based on the results of the calculations which have been matched to the results of the in situ measurements, the obtained values of the parameters of the pavement model within LDSD zone and outside it, were analysed. The results of pavement tests indicate at least a threefold increase in pavement deflections in the discontinuous deformation zone compared to deflections in the sections not affected by LDSD. The results of in situ tests and computational analysis presented in the paper allow their use in pavement reinforcement design in the area of anticipated LDSD.
A new statistic for detecting outliers in Rayligh distribution
Authors: Deiri Einolah 
Published: September 2020

AbstractZerbet and Nikulin (Commun Statist Theor Meth 32(3): 573–583, 2003) presented the new statistic $${Z}_{k}$$

Z
k

for detecting outliers in exponential distribution. They also compared this statistic with Dixon's statistic $${D}_{k}$$

D
k

. Jabbari et al. (Commun Statist Theor Meth 39(4): 698–706, 2010) expend this statistic ($${Z}_{k}$$

Z
k

) for Gamma distribution. In this paper, we generalize statistics $${Z}_{k}$$

Z
k

–$${Z}_{k}^{*}$$

Z

k

∗

, for detecting outliers in Rayligh distribution and compare the results with the generalized Dixon's statistic. Distribution of the test based on the statistic $${Z}_{k}^{*}$$

Z

k

∗

under slippage alternatives is obtained. The criterion value and power of the new test are also calculated and compared with the criterion value of the Dixon's statistic. The results show that the test based on statistic $${Z}_{k}^{*}$$

Z

k

∗

is more powerful than the test based on the statistic $${D}_{k}$$

D
k

.
Covid-19 and the Epigenetics of Learning
Authors: Johnson Mark William , Maitland Elizabeth , Torday John 
Published: September 2020

AbstractCovid-19 is a natural phenomenon that has rapidly upended much of the cultural infrastructure of societies across the globe. Education, which in recent years increasingly tied itself to notions of global culture and markets, is deeply threatened by these changes to the natural environment. This paper makes the case that the relationship between nature and culture in education requires a deep level analysis of the biological and physical substrate of human learning. Only with a sufficiently fundamental level of analysis can society reorganise its systems of learning and scientific inquiry to this rapidly changing environment. Drawing on evolutionary biology, we argue that institutional and individual structures and processes are recapitulations of evolutionary cellular development. Understanding the impact of Covid-19 on cells presents an invitation to consider the larger-scale cultural recapitulations of similar mechanisms and structures, and this has implications for the ways education might most effectively deploy technology. Whilst universities seek to maintain their existing structures, practices and business models, a cellular evolutionary approach points to the necessity for fundamental rethinking of intellectual life and learning. We consider the parameters of effective educational organisation in a post-Covid-19 world. As the richness and variety of the physical campus is removed, viable educational relationships will necessitate deeper intellectual connections and personal inquiries than are currently permitted in the transactional processes of education.
Supporting designers: moving from method menagerie to method ecosystem
Authors: Gericke Kilian , Eckert Claudia , Campean Felician , Clarkson P. John , Flening Elias , Isaksson Ola , Kipouros Timos , Kokkolaras Michael , Köhler Christian , Panarotto Massimo , Wilmsen Miriam 
Published: September 2020

AbstractSupporting designers is one of the main motivations for design research. However, there is an ongoing debate about the ability of design research to transfer its results, which are often provided in form of design methods, into practice. This article takes the position that the transfer of design methods alone is not an appropriate indicator for assessing the impact of design research by discussing alternative pathways for impacting design practice. Impact is created by different means – first of all through the students that are trained based on the research results including design methods and tools and by the systematic way of thinking they acquired that comes along with being involved with research in this area. Despite having a considerable impact on practice, this article takes the position that the transfer of methods can be improved by moving from cultivating method menageries to facilitating the evolution of method ecosystems. It explains what is understood by a method ecosystem and discusses implications for developing future design methods and for improving existing methods. This paper takes the position that efforts on improving and maturing existing design methods should be raised to satisfy the needs of designers and to truly support them.
Law and Moral Regulation in Modern Egypt:Ḥisbafrom Tradition to Modernity
Authors: Ezzat Ahmed 
Published: September 2020

AbstractThis article examines the historical roots of juridical moral regulation in modern Egypt, assessing the relationship between modern law and shariʿa through the lens of the influence of the Islamic practice ofḥisbaon courts and legislators. The article engages critically with scholarship on Islamic law and postcolonial theory regarding the impact of Western colonialism on law in Muslim societies and problematizes the understanding that shariʿa was secularized in the Egyptian legal culture through the translation of Western legal concepts. Instead, a different narrative is offered, one that recognizes the agency of local actors in the process of secularization and considers the influence of shariʿa in the legal development of contemporary Egypt.
Subgenual activation and the finger of blame: individual differences and depression vulnerability
Authors: Lythe Karen E , Gethin Jennifer A , Workman Clifford I , Lambon Ralph Matthew A. , Deakin John F.W. , Moll Jorge , Zahn Roland 
Published: September 2020

AbstractBackgroundSubgenual cingulate cortex (SCC) responses to self-blaming emotion-evoking stimuli were previously found in individuals prone to self-blame with and without a history of major depressive disorder (MDD). This suggested SCC activation reflects self-blaming emotions such as guilt, which are central to models of MDD vulnerability.MethodHere, we re-examined these hypotheses in an independent larger sample. A total of 109 medication-free participants (70 with remitted MDD and 39 healthy controls) underwent fMRI whilst judging self- and other-blaming emotion-evoking statements. They also completed validated questionnaires of proneness to self-blaming emotions including those related to internal (autonomy) and external (sociotropy) evaluation, which were subjected to factor analysis.ResultsAn interaction between group (remitted MDD v. Control) and condition (self- v. other-blame) was observed in the right SCC (BA24). This was due to higher SCC signal for self-blame in remitted MDD and higher other-blame-selective activation in Control participants. Across the whole sample, extracted SCC activation cluster averages for self- v. other-blame were predicted by a regression model which included the reliable components derived from our factor analysis of measures of proneness to self-blaming emotions. Interestingly, this prediction was solely driven by autonomy/self-criticism, and adaptive guilt factors, with no effect of sociotropy/dependency.ConclusionsDespite confirming the prediction of SCC activation in self-blame-prone individuals and those vulnerable to MDD, our results suggest that SCC activation reflects blame irrespective of where it is directed rather than selective for self. We speculate that self-critical individuals have more extended SCC representations for blame in the context of self-agency.
Tailoring cognitive behavioural therapy to subtypes of voice-hearing using a novel tabletised manual: a feasibility study
Authors: Dodgson Guy , Alderson-Day Ben , Smailes David , Ryles Faye , Mayer Claire , Glen-Davison Joanne , Mitrenga Kaja , Fernyhough Charles 
Published: September 2020

AbstractBackground:Cognitive behavioural therapy for psychosis (CBTp) is a recommended treatment for psychotic experiences, but its effectiveness has been questioned. One way of addressing this may be to tailor therapy materials to the phenomenology of specific psychotic experiences.Aim:In this study, we investigated the acceptability of a novel treatment manual for subtypes of ‘voice-hearing’ experiences (i.e. auditory verbal hallucinations). An uncontrolled, single-arm design was used to assess feasibility and acceptability of using the manual in routine care for people with frequent voice-hearing experiences.Method:The manual was delivered on a smart tablet and incorporated recent research evidence and theory into its psychoeducation materials. In total, 24 participants completed a baseline assessment; 19 started treatment, 15 completed treatment and 12 participants completed a follow-up assessment (after 10 sessions of using the manual).Results:Satisfaction with therapy scores and acceptability ratings were high, while completion rates suggested that the manual may be more appropriate for help with participants from Early Intervention in Psychosis services rather than Community Mental Health Teams.Conclusion:Within-group changes in symptom scores suggested that overall symptom severity of hallucinations – but not other psychosis features, or beliefs about voices – are likely to be the most appropriate primary outcome for further evaluation in a full randomised controlled trial.
Poor appetite and overeating reported by adults in Australia during the coronavirus-19 disease pandemic: a population-based study
Authors: Owen AJ , Tran T , Hammarberg K , Kirkman M , Fisher JRW 
Published: September 2020

AbstractObjective:As a result of the coronavirus-19 disease (COVID-19) pandemic, Australia adopted emergency measures on 22 March 2020. This study reports the effect of the COVID-19 lockdown on appetite and overeating in Australian adults during the first month of emergency measures.Design:This study reports analysis of data from the population-based, self-completed survey. The main outcome measure was an item from the Patient Health Questionnaire 9 asking: ‘Over the past 2 weeks, how often have you been bothered by poor appetite or overeating?’. Data on sociodemographic factors, symptoms of anxiety and depression, and the impact of COVID-19 and lockdown were also collected. Multivariable logistic regression was used to examine associations with poor appetite or overeating.Setting:An anonymous online survey available from 3 April to 2 May 2020.Participants:A total of 13 829 Australian residents aged 18 years or over.Results:The weighted prevalence of being bothered by poor appetite or overeating in the past 2 weeks was 53·6 %, with 11·6 % (95 % CI 10·6, 12·6) of the cohort reporting poor appetite or overeating nearly every day. High levels of anxiety, concern about contracting COVID-19, being in lockdown with children and reporting a severe impact of the lockdown were associated with increased odds of poor appetite or overeating.Conclusions:Given the widespread prevalence of being bothered by poor appetite or overeating, universal public health interventions to address emotion-focused or situational eating during periods of lockdown may be appropriate.