bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Indeks Massa Tubuh (IMT), Kadar Hemoglobin dan Paparan Asap Rokok dengan Kejadian Dismenore
Authors: Arisani Greiny 
Published: November 2019

Reproductive health is an important problem for adolescents. The earliest change in adolescents is to start menstruating which can cause dysmenorrhea. Dysmenorrhea affects learning activities and indirectly affects the quality of life of adolescents. There are several risk factors that are considered to have a relationship with dysmenorrhea including body mass index (BMI), hemoglobin levels and exposure to cigarette smoke. This study aims to determine the relationship of body mass index (BMI), hemoglobin levels and exposure to cigarette smoke with the occurrence of dysmenorrhea. This study was an observational analytic study with astudy design Cross Sectional. The sample in this study were female students of the Midwifery Department of Health at the Palangka Raya Ministry of Health. The research instruments were in the form of questionnaires s. Data analysis was done by Chi Square and Logistic Regression. The statistical test results showed a significant relationship between Body Mass Index (BMI), Hemoglobin Levels and Cigarette Smoke Exposure with Occurrence of Dysmenorrhea (p <0.05). The results of the logistic regression analysis obtained a determination coefficient value of 0.461 so that it can be concluded that the variable body mass index (BMI), hemoglobin level and exposure to cigarette smoke had a contribution of 46.1% to the incidence of dysmenorrhea and 53.9% influenced by other factors. Body Mass Index (BMI) OR = 14,920, Hemoglobin Level (Hb <12 gram / dl) OR = 5,897 and cigarette smoke exposure OR = 3,289 is a risk factor for dysmenorrhea in adolescents.
Pengaruh Biochar Sekam Padi dan Kompos Paitan (Tithonia diversifolia) terhadap Pertumbuhan Tanaman Kacang Hijau(Vigna radiata L.) di Tanah Miditeran
Authors: Sadzli Muhammad Amin , Supriyadi Slamet 
Published: November 2019

Biochar adalah padatan berwarna hitam mirip arang hasil pirolisis materi kaya karbon yang mampu memperbaiki sifat-sifat tanah termasuk peningkatkan kandungan C-organik dalam tanah. Penambahan kompos pada biochar kemungkinan akan meningkatkan kinerja biochar sebagai pembenah tanah. Penelitian ini bertujuan mengkaji interaksi antara biochar sekam padi dan kompos Tithonia pada pertumbuhan kacang hijau (Vigna radiata L.). Penelitian dilaksanakan dari bulan Mei hingga Agustus 2018, dalam Rumah plastik di Kebun Percobaan Agroteknologi, Fakultas Pertanian, Universitas Trunojoyo Madura, terletak di ketinggian ± 5 m dpl. Percobaan disusun dalam Rancangan Acak Lengkap (RAL) dengan 2 faktor, yaitu penambahan kompos Thitonia dalam takaran 0 (P0) dan 5 (P1) ton/ha; dan faktor kedua adalah penambahan biochar sekam padi sebanyak 0 (B0), 5 (B1), 10 (B2), dan 10 (B3) ton/ha. Hasil penelitian menunjukkan terdapat pengaruh interaksi biochar sekam padi dan kompos Tithonia terhadap pertumbuhan kacang hijau (Vigna radiata L.) pada parameter tinggi tanaman 3 MST, meningkatan kandungan C-organik tanah hingga 180%, dan menurunkan Bobot Isi (BI) tanah, dan cenderung menurunkan persentase bintil akar efektif. Efek biochar secara umum lebih baik jika konpos diikutkan daripada diberikan terpisah.
Lymph node metastasis around the entrance point to recurrent laryngeal nerve in papillary thyroid carcinoma
Authors: Lv Tian , Liu Zhuoran , Kuang Jie , Yan Jiqi 
Published: November 2019

Abstract
Background: There were few reports on the lymph nodes of entrance point to recurrent laryngeal nerve (LN-epRLN) in the patients with papillary thyroid carcinoma (PTC). Therefore, we aimed to increase acknowledgement of LN-epRLN and explore clinical implication. Methods: A prospective analysis including 878 consecutive patients with PTC who underwent thyroidectomy from April 2016 to March 2017 was performed. We explored the surrounding tissue of entrance point to recurrent laryngeal nerve, during routine central lymph node dissection (CLND). The lymph node specimens were sent separately for routine histopathological examination, and the complications and follow-ups were recorded. Results: LN-epRLN was found in 73 of the 878 patients and the metastasis rate was 3.76%. In univariate analysis, LN-epRLN metastasis was correlated with further central nodal metastasis, tumor location in the upper third of the thyroid and tumor multifocality. Conclusions: LN-epRLN can be the site of metastasis of PTC, and the positive LN-epRLN was highly predictive of other central nodal metastasis. LN-epRLN metastases in PTC were also associated with tumor location in the isthmus or upper third of the thyroid and tumor multifocality. In our study, we focus on acknowledgement of LN-epRLN. We emphasized the value of exactitude anatomy and the thoroughness of CLND for cN0-1a PTC.
The risk of cesarean delivery after labor induction among women with prior pregnancy complications: A subgroup analysis of the AFFIRM study
Authors: Skeith Leslie , Gal Grégoire Le , de Vries Johanna IP , Middeldorp Saskia , Goddijn Mariëtte , Kaaja Risto , Gris Jean-Christophe , Martinelli Ida , Schleußner Ekkehard , Petroff David , Langlois Nicole , Rodger Marc A. 
Published: November 2019

Abstract
Objective: To determine the risk of cesarean delivery after labor induction among patients with prior placenta-mediated pregnancy complications (pre-eclampsia, late pregnancy loss, placental abruption or intrauterine growth restriction). Study Design: The AFFIRM database includes patient level data from 9 randomized controlled trials that evaluated the role of LMWH versus no LMWH during pregnancy to prevent recurrent placenta-mediated pregnancy complications. The primary outcome of this sub-study was the proportion of women who had an unplanned cesarean delivery after induction of labor compared to after spontaneous labor. Results: There were 512 patients from 7 randomized trials included in our sub-study. There was no difference in the risk of cesarean delivery between women with labor induction (21/148, 14.2%) and spontaneous labor (79/364, 21.7%) (odds ratio (OR) 0.60, 95% CI, 0.35-1.01; p=0.052). Among 274 women who used LMWH prophylaxis during pregnancy, the risk of cesarean delivery was lower among those that underwent labor induction (9.8%) compared to spontaneous labor (22.4%) (OR 0.38, 95% CI, 0.17-0.84; p=0.01). Conclusions: The risk of cesarean delivery is not increased after labor induction among a higher risk patient population with prior pregnancy complications. Our results suggest that women who receive LMWH during pregnancy might benefit from labor induction.
Comparative study of Revogene GBS LB Assay and GeneXpert GBS LB Assay for the detection of Group B Streptococcus in prenatal screening samples.
Authors: Choera Tsokyi , Jung-Hynes Brittney , Chen Derrick J. 
Published: November 2019

Abstract
Background: Group B Streptococcal (GBS) infections in the United States are a leading cause of meningitis and sepsis in newborns. The CDC, therefore recommends GBS screening for all pregnant women at 35–37 weeks of gestation and administration of intrapartum prophylaxis (in those that tested positive) as an effective means of controlling disease transmission. Several FDA approved molecular diagnostic tests are available for rapid and accurate detection of GBS in antepartum women.
Method: In this study, we report a clinical comparison of the Xpert GBS LB assay and a novel FDA-cleared test, Revogene GBS LB assay. A total of 250 vaginal-rectal swabs from women undergoing prenatal screening were submitted to the University of Wisconsin’s clinical microbiology laboratory for GBS testing.
Results: We found 96.8% of samples were concordant between the two tests, while 3.2% were discordant with a positive percent agreement of 98.0% and a negative percent agreement of 96.5% between the Revogene GBS LB assay and the GeneXpert GBS LB assay.
Conclusion: Overall, we report that both assays perform well for the detection of GBS colonization in pregnant women.
Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age
Authors: Diena Davide , Messina Maria , De Biase Consuelo , Fop Fabrizio , Scardino Edoardo , Rossetti Maura Maria , Barreca Antonella , Verri Aldo , Biancone Luigi 
Published: November 2019

Abstract
Background
Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored.
Methods
This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day.
Results
Transplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p < 0.05; Odd Ratio 1.8). 1-year graft function (eGFR < or ≥44 ml/min) had similar impact to proteinuria (≥ 0.5 g/day) on graft failure (HR 2.77 vs HR 2.46). Low-grade proteinuria (0.2-0.5 g/day) demonstrated a trend for worse graft survival with increasing donor age. Also in kidney-paired analysis proteinuria ≥ 0.5 effect was more significant with donors >50 years old (OR 2.3).
Conclusions
Post-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥ 0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others).
Simulation and minimization: Technical advances for factorial experiments designed to optimize clinical interventions
Authors: Kuhn Jocelyn Lara , Sheldrick Radley Christopher , Broder-Fingert Sarabeth , Chu Andrea , Fortuna Lisa , Jordan Megan , Rubin Dana , Feinberg Emily 
Published: November 2019

Abstract
Background: The Multiphase Optimization Strategy (MOST) is designed to maximize the impact of clinical healthcare interventions, which are typically multicomponent and increasingly complex. MOST often relies on factorial experiments to identify which components of an intervention are most effective, efficient, and scalable. When assigning participants to conditions in factorial experiments, researchers must be careful to select the assignment procedure that will result in balanced sample sizes and equivalence of covariates across conditions while maintaining unpredictability. Methods: In the context of a MOST optimization trial with a 2x2x2x2 factorial design, we used computer simulation to empirically test five subject allocation procedures: simple randomization, stratified randomization with permuted blocks, maximum tolerated imbalance (MTI), minimal sufficient balance (MSB), and minimization. We compared these methods across the 16 study cells with respect to sample size balance, equivalence on key covariates, and unpredictability. Leveraging an existing dataset to compare these procedures, we conducted 250 computerized simulations using bootstrap samples of 304 participants. Results: Simple randomization, the most unpredictable procedure, generated poor sample balance and equivalence of covariates across the 16 study cells. Stratified randomization with permuted blocks performed well on stratified variables but resulted in poor equivalence on other covariates and poor balance. MTI, MSB, and minimization had higher complexity and cost. MTI resulted in balance close to pre-specified thresholds and a higher degree of unpredictability, but poor equivalence of covariates. MSB had 19.7% deterministic allocations, poor sample balance and improved equivalence on only a few covariates. Minimization was most successful in achieving balanced sample sizes and equivalence across a large number of covariates, but resulted in 34% deterministic allocations. Small differences in proportion of correct guesses were found across the procedures. Conclusions: Based on the computer simulation results and priorities within the study context, minimization with a random element was selected for the planned research study. Minimization with a random element, as well as computer simulation to make an informed randomization procedure choice, are utilized infrequently in randomized experiments but represent important technical advances that researchers implementing multi-arm and factorial studies should consider.
Associations Between Psychoactive Substance Use And Sensation Seeking Behavior Among Drivers In Norway
Authors: Jamt Ragnhild Elén Gjulem , Gjerde Hallvard , Furuhaugen Håvard , Romeo Giovanni , Vindenes Vigdis , Ramaekers Jan G. , Bogstrand Stig Tore 
Published: November 2019

Abstract
Background/aim Drug use and risky driving is associated with sensation seeking. The aim of this study was to investigate the association between use of psychoactive substances and levels of the sensation seeking personality trait as measured with the Brief Sensation Seeking Scale 4 among drivers in Norway. Method A cross-sectional design was applied to estimate the association between psychoactive substance use and sensation seeking behavior. Drivers in normal traffic were included in two roadside surveys: one in the north (September 2014 – October 2015) and the other in the south-east of Norway (April 2016 – April 2017). Oral fluid was analyzed for alcohol and psychoactive drugs, and data on sex, age and time of participation were recorded. Participants filled in the Brief Sensation Seeking Scale 4 questionnaire. Results A total of 8053 drivers were included, of which 32% were women and 62% were under 40 years. The prevalence of alcohol was 0.3%, stimulants 0.6%, tetrahydrocannabinol 1.4%, benzodiazepines and/or z-hypnotics 2.0% and polydrug use 0.6%. Associations between the use of tetrahydrocannabinol or benzodiazepines and/or z-hypnotics and a low score on the “thrill and adventure seeking” domain of the Brief Sensation Seeking Scale 4 (OR = 1.723, 95% C.I. = 1.001- 2.966). Associations were also found between the use of stimulants and the highest scores on the “experience seeking” (OR = 2.085, 95% C.I. = 1.084-4.009) and “disinhibition” (OR = 4.791, 95% C.I. =1.748-13.135) domains of the Brief Sensation Seeking Scale 4. No associations were found between sensation seeking behavior and alcohol or polydrug use. Conclusion A high degree of sensation seeking was found among drivers who had used stimulating drugs, in contrast to drives who had used tetrahydrocannabinol and benzodiazepines and/or z-hypnotics who showed a low degree of sensation seeking. The combination of sensation seeking behavior and the use of stimulants might lead to increased risky behavior and thus traffic crashes.
Predicting peripartum blood transfusion: focusing on pre-pregnancy characteristics
Authors: Ouh Yung-Taek , Lee Kyu-Min , Ahn Ki Hoon , Hong Soon-Cheol , Oh Min-Jeong , Kim Hai-Joong , Han Sung Won , Cho Geum Joon 
Published: November 2019

Abstract
Background: Obstetric hemorrhage is one of the most common causes of obstetrical morbidity and mortality, and transfusion is the most important management for hemorrhage. The aim of our study was to investigate the pre-pregnancy and pregnancy risk factors for peripartum transfusion. Methods: Women who delivered a baby from 2010 to 2014 and participated in the National Health Screening Program for Infants and Children were included. To analyze pre-pregnant risk factors for peripartum transfusion, an additional analysis was done for women who underwent a National Health Screening Examination within one year before pregnancy, including maternal waist circumference, body mass index, blood pressure, laboratory tests and history of smoking. Multivariable logistic regression analysis was used to estimate the risk factors for peripartum transfusion. Results: Of the total 1,980,126 women who met the inclusion criteria, 36,868 (1.86%) were transfused at peripartum. In a multivariable regression model, the pregnancy risk factors for peripartum transfusion included maternal age above 35 years [odds ratio (OR): 1.41; 95% confidence interval (CI): 1.32–1.50], preterm birth (OR: 2.39; 95% CI: 2.15–2.65), and maternal hypertension (OR: 2.49; 95% CI: 2.24–2.77). Pre-pregnancy risk factors including fasting glucose level of more than 126 mg/dL (OR: 1.11; 95% CI: 1.02–1.20), current-smoker status (OR: 1.20; 95% CI: 1.06–1.37), and waist-circumference less than 80 cm (OR: 1.18; 95% CI: 1.06–1.30) were independently associated with peripartum blood transfusion. Conclusions: Several pre-pregnancy and pregnancy risk factors were associated with peripartum blood transfusion. Some identified factors are modifiable before conception, and our study validated peripartum blood transfusion as a form of triage. Keywords: Peripartum, Blood transfusion, Postpartum hemorrhage
Postoperative diastolic perfusion pressure is associated with the development of acute kidney injury in patients after cardiac surgery: A retrospective analysis
Authors: Jin Jifu , Yu Jiawei , Chang Su Chi , Xu Jiarui , Xu Sujuan , Jiang Wuhua , Shen Bo , Zhuang Yamin , Wang Chunsheng , Ding Xiaoqiang , Teng Jie 
Published: November 2019

Abstract
Background: We aimed to investigate the relationship between the perioperative hemodynamic parameters and the occurrence of cardiac surgery-associated acute kidney injury.
Methods: A retrospective study was performed in patients who underwent cardiac surgery at a tertiary referral teaching hospital. Acute kidney injury was determined according to the KDIGO criteria. We investigated the association between the perioperative hemodynamic parameters and cardiac surgery-associated acute kidney injuryto identify the independent hemodynamic predictors for acute kidney injury.Subgroup analysis was further performed in patients with chronic hypertension.
Results: Among 300 patients, 29.3% developed acute kidney injury during postoperative intensive care unit period. Multivariate logistic analysis showed the postoperative nadir diastolic perfusion pressure, but not mean arterial pressure, central venous pressure and mean perfusion pressure, was independently linked to the development of acute kidney injury after cardiac surgery (odds ratio 0.945, P = 0.045). Subgroup analyses in hypertensive subjects ( n = 91)showed the postoperative nadir diastolic perfusion pressure and peak central venous pressure were both independently related to the development of acute kidney injury (nadir diastolic perfusion pressure, odds ratio 0.886, P = 0.033; peak central venous pressure, odds ratio 1.328, P = 0.010, respectively).
Conclusions: Postoperative nadir diastolic perfusion pressure was independently associated with the development of cardiac surgery-associated acute kidney injury. Furthermore, central venous pressure should be considered as a potential hemodynamic target for hypertensive patients undergoing cardiac surgery.
Knowledge and practices regarding tuberculosis infection control among nurses in Ibadan, South-West Nigeria: a cross-sectional study
Authors: Akande Patrick Aboh 
Published: November 2019

Abstract
Background: Nurses are particularly vulnerable to nosocomial tuberculosis (TB) infection because, being in the frontline of patient care, they are frequently exposed to patients with infectious TB disease. Although cost-effective measures are available for TB infection control (TBIC), they are often poorly implemented. Knowledge of TBIC is known to positively influence the practice of the measures. There is however limited data on the knowledge and practice of TBIC among nurses in Nigeria. This study was aimed at determining the levels of TBIC-related knowledge and practices of nurses in Ibadan, and associated socio-demographic factors. Methods: This cross-sectional study utilized a self-administered questionnaire to collect data from 200 nurses in two secondary health facilities, in May 2014. STATA version 13 was used to analyze data: mean knowledge and practice scores of the nurses and logistic regression to explore their association with socio-demographic factors. Results: The respondents had mean knowledge and practice scores of 68.2% and 79.9% respectively. Using cut-off points of 80% and 100% for good knowledge and practice scores respectively, small proportions of the nurses had good scores- knowledge (10.5%) and practice (6%). Knowledge was found not to be significantly associated with the socio-demographic factors. Work experience was the only factor that was significantly associated with practice, with the more experienced nurses (>18 years of experience) having lesser odds of obtaining good practice scores (OR 0.25, 95%CI 0.06-0.94). Also, there was no significant association between knowledge and practice scores. No structured TBIC training had been conducted at this time. Conclusions: The study revealed that small proportions of the nurses had good knowledge and practice scores. The findings from this study will be useful for the planning of interventions to improve TBIC among nurses and other healthcare workers, and to benchmark monitoring and evaluation of the interventions. It is recommended that the nurses should be trained on TBIC to equip them with necessary knowledge and skills. This, together with appropriate TBIC policy directives, availability of TBIC equipment/supplies and facility architectural remodeling will contribute to optimal implementation of TB preventive measures.
Individual and healthcare system factors influencing antenatal care attendance in Saudi Arabia
Authors: Alanazy Wdad , Brown Amy 
Published: November 2019

Abstract
Background The World Health Organisation recommends women have at least 4 antenatal care visits (ANC) during a low risk pregnancy. However, in Saudi Arabia, many mothers miss these appointments placing their health and that of their baby at risk. Limited research exploring why this is happening usually focuses on low maternal education or personal barriers such as lack of transport. The aim of the current research was therefore to understand what factors at the individual and healthcare systems level were associated with missing antenatal care in Saudi Arabia.Methods Two hundred and forty two pregnant women in their third trimester completed a questionnaire examining their care attendance alongside barriers to attending care. These included maternal demographic background, health literacy, personal barriers, health care system factors and staff communication).Results Over half of women had missed at least one appointment and a third had delayed their care. Mothers who had missed appointments blamed health care system factors such as poor clinic facilities and waiting times. Attending care was not associated with maternal education or literacy. However perceptions of staff communication, consistency and care were lower amongst those who had missed at least one appointment.Conclusions Although in previous research health professionals believe it is maternal education that leads to poor attendance, in our sample at least, it is in fact perceptions of staff communication that affect attendance. Making changes at the health care level e.g. through adapting clinic times and investing in staff training may increase antenatal care attendance in Saudi Arabia.