bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of green mining practices on corporate sustainable development: role of green innovation, green organizational commitment, and corporate social responsibility
Authors: Jianchun Yu 
Published: December 2024

BackgroundChina is the top global consumer, importer, and producer of coal, accounting for about half of the world’s totals. Yet despite all this progress in renewable energy, coal still provided 56 percent of China’s energy consumption, and the country has the fourth-largest reserve globally. However, coal mining also releases enormous amounts of methane, a very potent greenhouse gas. Additionally, it contributes over 70% to the total CO2 within the country.PurposeThis study evaluates the effect of green mining practices on green innovation, employee green organizational commitment, and corporate sustainable development in the mining industry of China.MethodologyThe data was collected through an online survey and distributed all over China. For this research, 511 responses were analyzed using SmartPLS 4.1.ResultsThe results indicate that green marketing practices have a direct positive and significant effect on green innovation (β = 0.493), organizational commitment (β = 0.476), and organizational sustainable development (β = 0.0.195). The study proves that green innovation significantly affects both organizations’ sustainable development (β = 0.262) and their commitment (β = 0.0.293). Additionally, green innovation and organizational commitment significantly mediate the relationship between green marketing practices and corporate sustainable development. Moreover, the study observed that corporate social responsibility significantly moderated the influence of green mining practices on green innovation, organizational commitment, and corporate sustainable development. Cumulatively green mining practices, direct and indirect effects of green innovation and organizational commitment, and moderation of corporate social responsibility explained 67.2% variance in the corporate sustainable development.ConclusionThe study results further attest that green practices and corporate social responsibility play an essential role in underpinning sustainability and innovation in the mining sector. They also provide important lessons for policymakers and other industrial stakeholders on improving sustainable development.
Understanding the perceptions and reactions to a monthly oral contraceptive capsule with end users and healthcare providers in Bangladesh, Senegal, and Zimbabwe
Authors: El-Sahn Moushira , Elliott Rose , El-Sahn Mona , Lucas Jeff , Santos Trisha Wood 
Published: December 2024

IntroductionUnintended pregnancy is a global public health challenge. Many contraceptive methods are available to end users, but non-use and discontinuation due to health concerns or side effects, particularly related to unpredictable or undesirable menstrual bleeding, are common. Oral contraceptive pills (OCPs) often have regular bleeding patterns compared to other hormonal contraceptives but require daily adherence. To address the issues of bleeding-related side effects and daily adherence, researchers are developing a monthly oral contraceptive (MOC) containing the same hormones as common OCPs. We studied women's and healthcare providers’ (HCPs’) perceptions of the MOC technology with the primary goal of providing feedback on product attributes to inform early design decisions.MethodsOur study consisted of a qualitative phase with in-person in-depth interviews (IDIs) with a total of 60 women of reproductive age in three regions in three countries (Bangladesh, Senegal, and Zimbabwe) and quantitative surveys, which took place after the qualitative phase, via face-to-face computer-assisted interviews of a total of 1,825 women in 17 regions in these three countries. We conducted 96 IDIs and 632 quantitative interviews with HCPs in one urban area per country.ResultsWomen's and HCPs’ perceptions of MOC product attributes were assessed and included a focus on potential menstrual changes and possible reasons for discontinuation. Overall, the most appealing attribute of an MOC was its 1-month duration. Women and HCPs alike preferred regular, monthly menstruation. Any unpredictable or irregular bleeding, including heavy bleeding or amenorrhea, would be a reason to discontinue an MOC if it were to have those attributes.DiscussionOverall, an MOC has a high and broad level of appeal amongst all the groups of women and HCPs who participated in the study and has a strong value proposition for important contraceptive needs including convenient duration, ease of use, discretion, and acceptable side effects. This appeal assumes that the experience of using an MOC would be very similar to that of daily OCPs except for dose timing. Future research on a hormonal MOC should include an exploration of women's tolerance and acceptability of potential side effects, particularly regarding bleeding, to validate its value proposition.
Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice
Authors: Wang Chenlin , Wu Yanan , Liu Chao , Li Yang , Mi Song , Yang Xiaofan , Liu Tong , Tian Yuanjing , Zhang YingYing , Hu Pingping , Qiao Lili , Deng Guodong , Liang Ning , Sun Jinyue , Zhang Yan , Zhang Jiandong 
Published: December 2024

BackgroundPatients receiving chest radiation therapy, or exposed to high radiation levels due to accidental nuclear leakage are at risk of radiation-induced lung injury (RILI). In innate immunity, macrophages not only exhibit certain radiation tolerance but also play an important regulatory role in the whole pathological process. Nervonic acid (NA), a long-chain unsaturated fatty acid found in nerve tissue, plays a pivotal role in maintaining normal tissue growth and repair. However, the influence of NA on RILI progression has yet to be examined.AimThis study aimed to assess the role of macrophage subtypes in RILI and whether NA can alleviate RILI. Specifically, whether NA can alleviate RILI by targeting macrophages and reducing the levels of inflammatory mediators in mouse models was assessed.MethodsMice RILI model was employed with 13 Gy whole thoracic radiation with or without administration of NA. Various assays were performed to evaluate lung tissue histological changes, cytokine expression, IκB-α expression and the number and proportion of macrophages.ResultsRadiation can lead to the release of inflammatory mediators, thereby exacerbating RILI. The specific radiation dose and duration of exposure can lead to different dynamic changes in the number of subpopulations of lung macrophages. NA can affect the changes of macrophages after irradiation and reduce inflammatory responses to alleviate RILI.ConclusionMacrophages play a significant role in the integrated pathological process of lung injury after irradiation which shows a dynamic change with different times. NA can protect lung tissues against the toxic effects of ionizing radiation and is a new potential functional component for targeting macrophages.
Mitochondria-associated programmed cell death: elucidating prognostic biomarkers, immune checkpoints, and therapeutic avenues in multiple myeloma
Authors: Gao Gongzhizi , Miao Jiyu , Jia Yachun , He Aili 
Published: December 2024

BackgroundMultiple myeloma (MM) is a hematological malignancy characterized by the abnormal proliferation of plasma cells. Mitochondrial dysfunction and dysregulated programmed cell death (PCD) pathways have been implicated in MM pathogenesis. However, the precise roles of mitochondria-related genes (MRGs) and PCD-related genes (PCDRGs) in MM prognosis remain unclear.MethodsTranscriptomic data from MM patients and healthy controls were analyzed to identify differentially expressed genes (DEGs). Candidate genes were selected by intersecting DEGs with curated lists of MRGs and PCDRGs. Univariate Cox, least absolute shrinkage and selection operator (LASSO), multivariate Cox, and stepwise regression analyses identified prognostic genes among the candidates. A risk model was constructed from these genes, and patients were stratified into high- and low-risk groups for survival analysis. Independent prognostic factors were incorporated into a nomogram to predict MM patient outcomes. Model performance was evaluated using calibration curves, receiver operating characteristic (ROC) analysis, and decision curve analysis (DCA). Finally, associations between prognostic genes and immune cell infiltration/drug responses were explored.Results2,192 DEGs were detected between MM and control samples. 30 candidate genes were identified at the intersection of DEGs, 1,136 MRGs, and 1,548 PCDRGs. TRIAP1, TOMM7, PINK1, CHCHD10, PPIF, BCL2L1, and NDUFA13 were selected as prognostic genes. The risk model stratified patients into high- and low-risk groups with significantly different survival probabilities. Age, gender, ISS stage, and risk score were independent prognostic factors. The nomogram displayed good calibration and discriminative ability (AUC) in predicting survival, with clinical utility demonstrated by DCA. 9 immune cell types showed differential infiltration between MM and controls, with significant associations to risk scores and specific prognostic genes. 57 drugs, including nelarabine and vorinostat, were predicted to interact with the prognostic genes. Ultimately, qPCR in clinical samples from MM patients and healthy donors validated the expression levels of the seven key prognostic genes, corroborating the bioinformatic findings.ConclusionSeven genes (TRIAP1, TOMM7, PINK1, CHCHD10, PPIF, BCL2L1, NDUFA13) involved in mitochondrial function and PCD pathways were identified as prognostic markers in MM. These findings provide insights into MM biology and prognosis, highlighting potential therapeutic targets.
Multi-omics analysis and experiments uncover the function of cancer stemness in ovarian cancer and establish a machine learning-based model for predicting immunotherapy responses
Authors: Liu Zhibing , Han Lei , Ji Xiaoyu , Wang Xiaole , Jian Jinbo , Zhai Yujie , Xu Yingjiang , Wang Feng , Wang Xiuwen , Ning Fangling 
Published: December 2024

BackgroundThe heterogeneity of cancer makes it challenging to predict its response to immunotherapy, highlighting the need to find reliable biomarkers for assessment. The sophisticated role of cancer stemness in mediating resistance to immune checkpoint inhibitors (ICIs) is still inadequately comprehended.MethodsGenome-scale CRISPR screening of RNA sequencing data from Project Achilles was utilized to pinpoint crucial genes unique to Ovarian Cancer (OV). Thirteen publicly accessible OV transcriptomic datasets, seven pan-cancer ICI transcriptomic cohorts, and one single-cell RNA dataset from melanoma patients treated with PD-1 were utilized to scale a novel cancer stemness index (CSI). An OV single-cell RNA dataset was amassed and scrutinized to uncover the role of Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE) in the tumor microenvironment (TME). Vitro experiments were performed to validate the function of SNRPE in promoting proliferation and migration of ovarian cancer.ResultsThrough the analysis of extensive datasets on ovarian cancer, a specific gene set that impacts the stemness characteristics of tumors has been identified and we unveiled a negative correlation between cancer stemness, and benefits of ICI treatment in single cell ICI cohorts. This identified gene set underpinned the development of the CSI, a groundbreaking tool leveraging advanced machine learning to predict prognosis and immunotherapy responses in ovarian cancer patients. The accuracy of the CSI was further confirmed by applying PD1/PD-L1 ICI transcriptomic cohorts, with a mean AUC exceeding 0.8 for predicting tumor progression and immunotherapy benefits. Remarkably, when compared to existing immunotherapy and prognosis markers, CSI exhibited superior predictive capabilities across various datasets. Interestingly, our research unveiled that the amplification of SNRPE contribute to remodeling the TME and promoting the evasion of malignant cells from immune system recognition and SNRPE can server as a novel biomarker for predicting immunotherapy response.ConclusionsA strong relationship between cancer stemness and the response to immunotherapy has been identified in our study. This finding provides valuable insights for devising efficient strategies to address immune evasion by targeting the regulation of genes associated with cellular stemness.
Systemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis
Authors: Xiao Yue , Gao Jingya , Wang Yiyi , Hao Dan , Yan Wei , Wen Dingke , Zeng Siyi , Yang Shiqi , Shi Yingyu , Li Wei 
Published: December 2024

BackgroundPsoriasis is commonly associated with metabolic dysfunction-associated steatotic liver disease, raising concerns about the hepatic effects of systemic treatments on psoriasis and its comorbid conditions. This study evaluates liver stiffness measurement (LSM) alterations and identifies predictors of abnormal LSM in psoriatic patients following systemic treatments, including biologics and methotrexate.MethodsThis prospective cohort study is based on the PSOWCH database (Psoriasis Cohort of West China Hospital). We initially included psoriatic patients who had undergone sound touch elastography (STE), then recruited patients who had STE before systemic treatment and reassessed them after at least six months. Three treatment subgroups were formed (interleukin inhibitors, tumor necrosis factor inhibitors, and methotrexate), classifying post-treatment STE outcomes using threshold values of 6.5 kPa and 10.3 kPa.ResultsAmong the 52 recruited patients, overall STE values significantly increased during follow-up. Univariate regression analysis showed that age, gender, psoriasis severity, psoriatic arthritis status, and current treatment type were not significantly correlated with abnormal STE outcomes at cutoff values of 6.5 kPa and 10.3 kPa. In the multivariate model, body mass index (BMI) was identified as a risk factor for post-treatment STE ≥ 6.5 kPa (odds ratio [OR], 1.26; 95% CI, 1.04 to 1.60, P=0.031).ConclusionsThis exploratory study reveals that systemic treatment type is not associated with abnormal post-treatment LSM. However, a significant association exists between BMI and abnormal LSM outcomes. These findings highlight the critical importance of BMI management in therapeutic interventions for psoriasis.
Next-generation adjuvant systems containing furfurman drives potent adaptive immunity and host defense as a foot-and-mouth disease vaccine adjuvant
Authors: Kim Hyeong Won , Shin Seokwon , Park So Hui , Park Jong-Hyeon , Kim Su-Mi , Lee Yoon-Hee , Lee Min Ja 
Published: December 2024

IntroductionMany countries use commercial foot-and-mouth disease (FMD) vaccines to prevent FMD pandemics, but these vaccines have disadvantages, such as repeated vaccinations due to the short persistence of antibody (Ab) titers and incomplete host defense despite high Ab titers. To address these shortcomings, we aimed to develop a novel FMD vaccine containing furfurman as an adjuvant.MethodTo demonstrate the efficacy of the test vaccine, adaptive immunity was evaluated by measuring Ab and neutralizing Ab titers and host defense against viral infections in experimental and target animals. In addition, the expression levels of cytokines [interferon (IFN)α, IFNβ, IFNγ, interleukin (IL)-1β, IL-2, and IL-12p40] were evaluated at the early stages of vaccination to confirm the simultaneous induction of cellular and humoral immune responses induced by the test vaccine.ResultThe groups that received vaccine containing furfurman showed a strong early, mid-term, and long-term immune response and host defense against viral infections compared to the control groups. The significant upregulation observed in cytokine levels in the furfurman group compared to those in the control groups strongly suggest that the test vaccine strengthens cellular immune response and effectively induces a humoral immune response.ConclusionOur study demonstrated that furfurman, as an FMD vaccine adjuvant, achieves long-lasting immunity and host defense against viral infections by eliciting potent cellular and humoral immune responses. Therefore, our findings contribute to the design of next-generation FMD vaccines and highlight the potential application of furfurman as an adjuvant for other viral diseases.
Latitudinal trends in the biomass allocation of invasive Spartina alterniflora: implications for salt marsh adaptation to climate warming
Authors: Chen Yasong , Wu Fujia , Wang Yueyue , Guo Yangping , Kirwan Matthew L. , Liu Wenwen , Zhang Yihui 
Published: December 2024

IntroductionBiomass allocation between aboveground and belowground pools in salt marshes has distinct effects on salt marsh stability, and is influenced by climate warming and reproductive investment. However, the lack of studies on the effect of latitudinal variations in reproductive investments and biomass allocation in salt marshes makes it difficult to explore mechanisms of marsh plant growth to climate warming across geographical scales. The rapid invasion of the salt marsh grass Spartina alterniflora into lower latitude marshes around the world provides an opportunity to investigate biomass allocation and reproductive investment across latitudes, helping to understand how salt marshes respond to climate warming.MethodsTherefore, we investigated aboveground biomass (AGB), belowground biomass (BGB), total biomass, sexual reproduction traits (inflorescence biomass, flowering culm), asexual reproduction traits (shoot number, rhizome biomass), among S. alterniflora at 19 sites in 10 geographic locations over a latitudinal gradient of ~2000 km from Dongying (37.82°N, high latitude) to Danzhou (19.73°N, low latitude) in China.ResultsThe AGB, BGB, and total biomass displayed hump shaped relationships with latitude, but the BGB: AGB ratio decreased with increasing latitude (i.e. increased linearly with temperature). Interestingly, we found that the BGB: AGB ratio negatively correlated with sexual reproductive investment, but positively correlated with asexual reproductive investment.DiscussionWhile conceptual and numerical models of salt marsh stability and carbon accumulation often infer responses based on aboveground biomass, our study suggests that salt marsh responses to climate warming based on aboveground biomass and static allocations may bias estimates of future salt marsh production driven by climate warming.
Effects of polysaccharide fermentation with Bacillus coagulans on growth, antioxidant and immunity of Macrobrachium nipponense (riental river prawn)
Authors: Wang Yachao , Liang Yilei , Yu Jing , Li Zhengzhong , Wang Wei , Jiang Li , Liu Bo 
Published: December 2024

IntroductionIn recent years, with the continuous expansion of aquaculture areas worldwide and the outbreak of diseases, the use of antibiotics and chemical drugs is limited. Plant polysaccharides have received widespread attention due to their multiple bioactivities. However, research on the combined use of plant polysaccharides and Bacillus coagulans is still insufficient. Therefore, this study focuses on the impact of B.coagulans-fermented polysaccharides on Macrobrachium nipponense.MethodsAn 8-week feeding trial was conducted with seven groups: the control group (CT) and the Bacillus coagulans group (N),Atractylodes macrocephala polysaccharides group (NB), Saposhnikovia divaricata polysaccharides group (NF), Mannose group (NG), Astragalus polysaccharides group (NH) and Yu ping feng polysaccharides group (NP).Results and discussionThe research results indicate that compared to the CT, the levels of AST and ALT were reduced in the group of N, NF and NG. The NF showed a significant increase in total antioxidant capacity (T-AOC) and total superoxide dismutase (SASC) levels. The NP had a significant increase in T-AOC and superoxide anion scavenging ability. The levels of total protein (TP) and malondialdehyde (MDA) in the group of NG, NB, and NP were significantly higher than those in the CT and N. Compared to the CT, the expression of Toll in the NP group, Myd88 and Dorsal in the NH group, and IMD and Relish in the NF and NP group were all significantly increased. Conversely, the expression of IMD in the NB and NG group and Relish in the NG group was significantly decreased. Additionally, the survival rate in the NP group was significantly higher than in other groups, and the NB group enhanced the weight gain of M.nipponense compared to the N. In summary, B.coagulans fermented with Yupingfeng polysaccharides and Astragalus polysaccharides can significantly enhance the antioxidant and immune capabilities of M.nipponense.
Acupuncture and moxibustion as adjunctive therapy for postoperative gastrointestinal dysfunction in gastric cancer: a systematic review and network meta-analysis
Authors: Ou Yangxu , Lin Dezhi , Ni Xixiu , Feng Chengzhi , Rong Jing , Gao Xiaoyu , Yu Yang , Liu Xinrui , Zhang Zhiyang , Xiao Wang , Tang Zili , Zhao Ling 
Published: December 2024

ObjectivesThis study aimed to evaluate and compare the efficacy and safety of different acupuncture and moxibustion techniques as adjunctive therapy in addressing Postoperative gastrointestinal dysfunction (PGD) associated with gastric cancer (GC).MethodsEight medical databases were comprehensively searched for relevant randomized controlled trials (RCTs) as of October 2024. A network meta-analysis (NMA) was performed using frequency models, combining all available direct and indirect evidence from RCTs. Time of first bowel sounds (TFBS) was set as the primary outcome, and time to first defecation (TFD) and time to first flatus (TFF) were set as the secondary outcomes. All outcomes were ranked using surface under the cumulative ranking curve (SUCRA) probabilities to determine a hierarchy of treatments, and the probability that the intervention will be in one of the top ranks increases with a higher SUCRA value.ResultsWith 28 randomized controlled trials (RCTs) and 2,459 patients, 18 of which involved adjuvant acupuncture treatments. NMA based on SUCRA rankings showed that routine care (RC) with acupuncture (ACU), with acupressure (ACUP), with moxibustion (MOX) and acupoint injection (AI) were the top-ranked therapies for shortening TFBS and TFF in patients with GC compared with RC; additionally, RC + MOX + CUP and RC + MOX were the relatively best therapies for TFD. No serious adverse events were reported in the studies assessing the safety of adjunctive acupuncture therapy. Our study found that ST36, ST37, ST39, and PC6 were the most commonly used acupoints for adjuvant acupuncture treatments in treating PGD associated with GC.ConclusionAcupuncture and moxibustion, when used as supplementary therapies, demonstrated efficacy and relative safety in managing PGD associated with GC. The recommended order for adjunctive acupuncture- and moxibustion-related therapies for PGD in patients with GC, in terms of conservativeness, is as follows: RC + ACU, RC + MOX + AI, RC + ACUP, RC + MOX + CUP and RC + MOX. Despite their inclusion, the overall methodological quality of the studies was poor, which need for further high-quality randomized controlled trials to support existing results.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO.