bluuebunny/crossref_metadata_2025_split huggingface dataset:
La web semántica “guerra e historia pública” y la transferencia del conocimiento = The semantic web “Guerra e Historia Pública” and the transfer of knowledge
Authors: Villagrá Arnedo Carlos J. , López Javaloyes Juan Luis 
Published: May 2020

Resumen: La web semántica es una excelente herramienta para la transferencia y difusión del conocimiento y para la promoción del patrimonio cultural. Ofrece, además, muchas posibilidades para el trabajo colaborativo entre los profesionales de la investigación, docencia y el patrimonio cultural. En este texto se exponen las principales líneas de trabajo del proyecto "Guerra e Historia Pública", cuyo objetivo principal es la creación de una plataforma digital sobre la guerra de la Independencia española. Esta plataforma incluye una aplicación principal, la web semántica (https://www.guerra-historia-publica.es), que ofrece recursos inteligentes, todos ellos geolocalizados, y que pueden ser empleados desde distintos puntos de vista: docente, investigador, educativo y turístico. Al final del texto se presentan las conclusiones del trabajo realizado en dicha web.Palabras clave: guerra, historia pública, web semántica, plataforma digital, geolocalización.Abstract: The semantic web is an excellent tool for the transfer and dissemination of knowledge and for the promotion of cultural heritage. It also offers many possibilities for collaborative work among professionals in research, teaching and cultural heritage. This text presents the main lines of work of the project "Guerra e Historia Pública", whose main objective is the creation of a digital platform about the Spanish War of Independence. This platform includes a main application, the semantic web (https://www.guerra-historiapublica.es), which offers different smart resources, all of them geolocated, and which can be used from different points of view: teaching, research, education and tourism. The conclusions of the work carried out on this website are presented at the end of the text.Keywords: war, public history, semantic web, digital platform, geolocation.
Оптимумы солёности для вегетативного размножения и полового воспроизведения диатомовой водоросли Toxarium undulatum
Authors: Давидович Н. А. , Давидович О. И. 
Published: May 2020

Распространение диатомовых водорослей ограничивается пределами их толерантности по отношению к факторам среды. Род Toxarium представлен всего двумя видами, хотя его эволюция продолжается более 100 млн лет. Toxarium undulatum широко распространён в тропических и субтропических морях; он встречается и в Чёрном море, солёность которого вдвое ниже океанической. Представляет интерес изучение эколого-физиологических характеристик этого вида с точки зрения его отношения к солёности. Клоновые культуры T. undulatum выделены из проб, собранных в озере Донузлав, сообщающемся с Чёрным морем (юго-запад Крымского полуострова), и в прибрежье острова Гран-Канария (архипелаг Канарских островов). Эксперименты по изучению пределов толерантности по отношению к солёности показали, что черноморские клоны жизнеспособны в диапазоне, охватывающем как минимум 30 ‰ (от 12 до 42 ‰). Такой же широкий диапазон солёностной толерантности, слегка сдвинутый в сторону бόльших значений, наблюдали у океанических клонов этого вида. Установлены оптимумы для вегетативного роста и полового воспроизведения. У черноморских клонов они оказались равными 27,8 и 27,2 ‰ соответственно, что заметно выше солёности, которая наблюдается в месте обитания популяции. Аналогичное превышение положения оптимумов в отношении вегетативного размножения и полового воспроизведения по сравнению с теми уровнями солёности, в которых находятся природные популяции, было отмечено для ряда других черноморских диатомовых, что свидетельствует об их океаническом (средиземноморском) прошлом. Сделан вывод о том, что T. undulatum, наряду с другими видами, начал заселять черноморский бассейн ориентировочно семь тысяч лет назад, после того как в распреснённое Новоэвксинское море-озеро через образовавшийся пролив Босфор стала поступать вода из Средиземного моря. Между тем темпы эволюции не позволили привести физиологические и экологические характеристики изучаемого вида в полное соответствие с условиями окружающей среды. В его физиологических реакциях по отношению к солёности прослеживается океаническое происхождение. Обсуждается возможность видообразования в связи с заселением Чёрного моря океаническими видами.
К изучению макрофитобентоса прибрежной акватории Караджинского участка полуострова Тарханкут (Крым, Чёрное море)
Authors: Садогурский С. Е. 
Published: May 2020

Приведены сведения о составе и распределении макроводорослей в прибрежной акватории Караджинской бухты, примыкающей к южному кластеру особо охраняемой природной территории Национальный природный парк «Тарханкутский» (Крым, п-ов Тарханкут, Чёрное море). Специфика геоморфологического строения береговой зоны обусловливает структурные особенности макрофитобентоса и его промежуточное положение по отношению к макрофитобентосу прилегающих абразионных и аккумулятивных участков берега. Всего зарегистрировано 57 видов макроводорослей (Chlorophyta — 12, Ochrophyta (кл. Phaeophyceae) — 12, Rhodophyta — 33), из них 21 — в псевдолиторали и 56 — в сублиторали. Биомасса колеблется от 0,5 кг·м−2 в псевдолиторали до 4,5 кг·м−2 в сублиторали. Характер и количественные показатели бентосной растительности, состав флоры и соотношение эколого-флористических группировок макрофитобентоса в целом характерны для Тарханкутско-Севастопольского гидроботанического района Чёрного моря. Раритетная фракция включает 14 таксонов, занесённых в природоохранные списки различного ранга. Биотоп подлежит особой охране согласно Директиве ЕС о местообитаниях (Directive 92/43/EEC). Территориально-аквальный комплекс имеет созологическую и рекреационную ценность, его сохранение необходимо для обеспечения структурно-функциональной целостности экосистемы береговой зоны моря.
Systemic lupus erythematosus: what do Chinese patients and general practitioners know?
Authors: Wang Xia Jun , Sha Yue , Xu Dong , Chen lin Jia 
Published: May 2020

Abstract
Background: Systemic lupus erythematosus is a chronic autoimmune disease with multiple systems involved. Traditionally, the diagnosis and management of SLE is only limited at secondary and tertiary hospitals. In recent years, China has vigorously carried out the hierarchical medical system, which placed the emphasis on primary health care. It is said that general practitioner should provide recognition, monitoring, management and education for SLE patients, as well as coordinate closely with rheumatologist to optimize prognosis. However, little is known about GPs’ knowledge and attitude towards SLE in China, as well as SLE patients. Methods: Data were collected from 113 SLE patients and 225 community GPs. Patients were recruited from a rheumatology clinic, Peking Union Medical Hospital from October to December 2018. All the GPs involved in the study work in the community health centers in Beijing. Based on the self-designed questionnaire, a face-to-face questionnaire and internet-based questionnaire were conducted among SLE patients and GPs, respectively. Data was analyzed using SPSS 23.0 and knowledge level was reported as percent correct. Results: The average score of patients' disease knowledge was 6.99±2.21. The results showed that higher levels of education were associated with higher levels of knowledge (𝜒2=4.231, P=0.04), as was being married (𝜒2=27.781, P<0.001), employed (𝜒2=63.865, P<0.001), follow-up duration ≥10 years (𝜒2=26.174, P<0.001), frequency of hospitalization ≥3 times (𝜒2=22.44, P<0.001), more organs and systems involved (𝜒2=90.36, P<0.001). Univariate linear regression analysis showed that patients with lower age, higher levels of education, being married and shorter follow-up duration had higher educational needs (P<0.05). Moreover, GPs answered 47% of the questions correctly. They showed poor awareness of SLE diagnostic classification, signs of recurrence, complications and follow-up management. Conclusions: There are many gaps in SLE patients’ and GPs’ knowledge of the disease. And both of them have expressed the educational requirements of their expected aspects. Understanding the view of the SLE patients and GPs may help clinicians and policymakers focus their assessments and develop strategies to improve the management of SLE patients.
A newly revised pivot knee prosthesis for peri-knee malignant bone destruction tumor management
Authors: tan jie , Zhang Qingyi , Wu Wu , Li Yaxing , Huang Kai , Wang Lin , Rao Yong , Zhang Yue , Xue Hao , Zou Longfei , Zheng Shuling , Wang Zhi , Xie Huiqi 
Published: May 2020

Abstract
BackgroundThis study evaluated the effectiveness of a newly revised pivot knee prosthesis in patients with peri-knee malignant bone destruction tumors.MethodsMedical records of patients who were admitted to our hospital from January 2014 to February 2020 and underwent the newly revised pivot knee prosthesis operations were retrospectively collected and analyzed. Visual analogue scale (VAS), hospital special surgery (HSS) knee score, American knee society knee score (KSS), and ROM for pre-operation, discharge, and last follow-up were applied to assess the effectiveness of this surgery. Meanwhile, the results of musculoskeletal tumor society system (MTSS) and radiographs were observed and analyzed at last follow-up.ResultsThe average operation time was 174.0 ± 35.5 min, and intraoperative bleeding volume was 271.2 ± 127.3 ml. The follow-up time was 33.8 ± 14.9 months. The scores of VAS, HSS, and KSS at pre-operation, discharging, and last follow-up were all comparable (p༜0.05), ROM was only comparable between discharging and last follow-up (p༜0.05), while ROM between preoperative and discharging had no significance (p༞0.05). MTSS at last follow-up was22.6 ± 2.4. All patients were alive with their prosthesis in good condition except for one patient who underwent revision surgery for misalignment of prosthesis and two patients who died of systemic metastasis.ConclusionThe newly revised pivot knee prosthesis is a good alternative limb-salvage strategy for patients who suffered from bone destruction tumors, although patient tumor stage and health condition should be fully assessed before surgery to reduce the mortality rate of patients who are not eligible.
Semi-pilot production of xanthan gum using nejayote as culture medium substrate
Authors: Orozco-Flores Alonso A. , Zúñiga-Sánchez Jesús O. , Iracheta-Cárdenas Maria M. , Gomez-Flores Ricardo , Romo-Sáenz César I. , Rodríguez-Padilla Cristina , Tamez-Guerra Patricia 
Published: May 2020

Abstract
Background: Xanthan gum is an industrialized polysaccharide produced by Xanthomonas genus. Alternative carbon sources for Xanthomonas culturing may help reducing its production cost. Nejayote, a residue from maize nixtamalization process, is an alternative culture medium substrate to produce xanthan. In this study, industrial and semi-industrial nejayote alone or in combination with supplements, were tested for xanthan production by Xantomonas campestris (1 × 108 cells/mL inoculum), using YGC medium as control, in 100 mL and 1 L volumes. Cellular growth was determined by the colorimetric MTT reduction assay (OD 540 ). Xanthan pyruvate and acetyl groups from nejayote plus supplement cultures in the bioreactor were evaluated (OD 570). Results: Industrial nejayote steadily produced up to 4 g/L xanthan, as compared with YGC medium control, which increased its production over time up to 9.3 g/L at 96 h. Cellular activity assay revealed that the highest values after 24 h (3.88 and 2.71 OD 540 for YGC and industrial nejayote, respectively). Nejayote supplemented with MgSO4 •7 H2O resulted in the highest xanthan production (10.8 g/L), but low cell growth (3.6 and 1.82 OD 540 for YGC and nejayote plus supplement, respectively), after 96 h of culture. Furthermore, gum yield reached up to 6 g/L and 1.9 OD 540, after 96 h of nejayote plus supplement culture, using a 14 L bioreactor. Xanthan pyruvate and acetyl groups from nejayote plus supplement cultures in the bioreactor resulted in similar amounts (0.107 and 0.130 OD 570 , respectively), compared with a commercial biopolymer (0.148 and 0.127 OD 570 respectively). Conclusions: X. campestris effectively grew and produced industrial-quality xanthan gum in nejayote substrate-containing culture medium, thus providing an inexpensive alternative for bioremediation.
Laparoscopic Versus Open Abdominal Radical Hysterectomy for Patients with Endometrial Cancer Involving Cervix
Authors: Wang Ming , Zhao Ziyi , Xu Xiaohong , Miao Jinwei , Kong Weimin , Duan Wei , Su Li , Yin Ziran , Wu Yumei 
Published: May 2020

Abstract
BACKGROUND: Data on the survival outcome between laparoscopic and open abdominal radical hysterectomy is limited in patients with endometrial cancer involving cervix.METHODS: We performed a retrospective 1:1 matched observational study in patients who had their cervix involved by endometrial cancer during the 2010–2018 period in Beijing Obstetrics and Gynecology Hospital in China. All enrolled patients underwent cancer-directed radical hysterectomy through laparoscopic approach or open abdominal surgery and followed until 3 years after the surgery. The primary outcome was the rates of disease-free survival and overall survival.RESULTS: A total of 142 patients were included in the study, 54 patients received laparoscopic surgery and 54 of the remaining 88 patients who received open surgery were selected as control. Overall, the median follow-up duration was 54.22 ± 31.14 months (95%CI: 48.71–59.89 months). There was no difference on the baseline information between two groups, including ages, rates of histologic subtypes, rates of deep myometrial invasion, rates of lymph-node involvement, and postoperative stage. There was no significant difference between the three-year disease-free rates between two groups (3-year rate, 94.3% vs. 92.2%; hazard ratio, 1.36; 95% CI, 0.40 to 4.61). The 3-years rate of overall survival in patients of the laparoscopic group was comparable to patients in the open surgery group (3-year rate, 89.87% vs. 92.14%; hazard ratio for death from any cause, 1.87; 95% CI, 0.60 to5.86).CONCLUSIONS: This study revealed that laparoscopic approach surgery was not associated with shorter disease-free survival and overall survival than open abdominal radical hysterectomy in patients with endometrial cancer involving cervix.
Quality of Care for Children with Malaria at Private Health Facilities in Mid-Western Region of Uganda: A Cross Section Study
Authors: Wanzira Humphrey , Tumwine Daniel , Bukoma Patrick , Musiime Allan , Biculu Juliet , Ediamu Tom , Gudoi Samuel , Tibenderana James , Mulebeke Ronald , Nantanda Rebecca , Achan Jane 
Published: May 2020

Abstract
Background Approximately 50 percent of the population in Uganda seeks health care from private facilities but there is limited data on the quality of care for malaria in these facilities. This study aimed to document the quality of malaria case management in private health facilities in nine districts in the Mid-Western region of Uganda, an area of moderate malaria transmission.Methods This was a cross sectional study in which purposive sampling was used to select fifteen private-for-profit facilities from each district. An interviewer-administered questionnaire that contained both quantitative and open-ended questions was used. Information was collected on availability of treatment aides, knowledge on malaria, malaria case management, laboratory practices, malaria drugs stock and data management. We determined the proportion of health workers that adequately provided malaria case management according to national standards.Results Of the 135 health facilities staff interviewed, 61.48% (52.91 - 69.40) had access to malaria treatment protocols while 48.89% (40.19 - 57.63) received malaria training. The majority of facilities, 98.52% (94.75 - 99.82) had malaria diagnostic services and the most commonly available anti-malarial drug was artemether-lumefantrine, 85.19% (78 - 91), followed by Quinine, 74.81% (67 - 82) and intravenous artesunate, 72.59% (64 – 80). Only 14.07% (8.69 – 21.10) responded adequately to the acceptable cascade of malaria case management practice. Specifically, 33.33% (25.46 - 41.96) responded correctly to management of a patient with a fever, 40.00% (31.67 - 48.79) responded correctly to the first line treatment for uncomplicated malaria, whereas 85.19% (78.05 - 90.71) responded correctly to severe malaria treatment. Only 28.83% submitted monthly reports, where malaria data was recorded, to the national database.Conclusion This study revealed sub-optimal malaria case management practices at private health facilities with approximately 14% of health care workers demonstrating correct malaria case management cascade practices. This was due to limited access to malaria case management protocols and guidelines, lack of adequate staff training and supportive supervision, stock-outs of essential anti-malarial commodities and inadequate malaria related community level sensitization. The national malaria control programme could consider this information to inform specific areas of focus for strengthening malaria case management in the private health facilities.
Prognostic Value Of Leukocytosis In Pediatric Head Trauma
Authors: Sahin Levent , Kayabas Murat , Aras Levent 
Published: May 2020

Abstract
Purpose

Our aim in this study is to investigate the relationship between age, gender, trauma etiology, presence of symptoms at the time of admission, Glasgow Coma Scale (GCS), brain CT findings and blood WBC levels at admission.
Methods

305 pediatric patients [between 0 and 18 years old] who applied to the emergency department of Kafkas University Medical Faculty Hospital between 2016 and 2019 after head trauma were included in the study. The data of these patients were analyzed retrospectively from the hospital records. Age, gender, head trauma etiology, GCS scores at the time of presentation, their symptoms, their brain CT findings and blood WBC levels were examined. Chi-square test was performed between patients with and without leukocytosis and independent variables.
Results

After applying exclusion factors, the data of 173 patients who underwent CT in the emergency room after head trauma and whose blood tests were studied were examined. When patients were analyzed according to gender, 111 (64.2%) were male and 62 (35.8%) were found to be female. In terms of age, it was seen that those between the ages of 0 and 2 were 54 (31.2%), and those between the ages of 2- and 18 were 119 (68.8%). Among the etiological causes of traumas, the most frequent (n = 113) 65.3% falls were seen. The number of patients with symptoms was 57 (32.9%). Patients with GCS 14 ≥ constituted 69.4% of the total patients (n = 120). There was a pathological finding in 19.0% of the brain CT' s (n = 33) taken. Leukocytosis was detected in 17.3% of the patients [n = 30].
Conclusion

As a result of this study, it was found statistically significant that the blood WBC levels were higher in children who had head trauma, whose GCS was 13 ≤ at the time of application, who had symptoms and who had pathology in brain CT compared to other groups.
Abnormal Histones Acetylation In Patients With Primary Sjögren’s Syndrome
Authors: Li Yan , Lv Xiuying , Zhou Mi , He Yan , Wang Ying , Xuan Jingxiu , Shi Guixiu 
Published: May 2020

Abstract
Background

pSS is an autoimmune disease characterized by an exocrine gland epithelium injury with dense lymphocytic infiltration, involvement of the peripheral nervous, pulmonary, blood, kidney, skin, and joint. Aberrant histone acetylation is increasingly thought to plays important role in the pathogenesis of AIDs. However, there is very little data on histone acetylation in pSS.
Methods

We investigated the expressions of HAT genes (p300, CREEBP and PCAF) by real time PCR in PBMCs from pSS patients. HAT activity and histone H3/ H4 acetylation activity measured by activity kit and histone H3/H4 acetylation verified by WB. Spearman test was utilized to analyze the association between levels of HAT activity and clinical parameters of patients with pSS.
Results

The expressions of p300, CREEBP and PCAF in PBMCs from pSS patients were decreased in mRNA comparison with HCs. HAT activity and histone H3/H4 acetylation were reduced in PBMCs from pSS patients. We found negatively correlations between the HAT activity and CRP and TNF-α, and positively correlations between the HAT activity and C4.
Conclusions

Histone hypoacetylation is observed in patients with pSS and involved in the disease duration of Sjogren's syndrome.
Sex-related differences in clinical characteristics and comorbidities and their impact on clinical outcome in Korean patients with rheumatoid arthritis
Authors: Shin Seunghwan , Park Eun Hye , Kang Eun Ha , Lee Yun Jong , Song Yeong Wook , Ha You-Jung 
Published: May 2020

Abstract
Backgrounds:

Rheumatoid arthritis (RA) is more prevalent in women and prior studies have reported several epidemiologic differences between sex and low achievement of remission in women RA. However, these sex differences across various populations remain incompletely understood. This study aimed to elucidate sex-related differences in clinical characteristics and their potential impact on clinical outcome in a large Korean cohort of patients with RA.
Methods

In total, 5,376 RA patients from the KORean Observational study Network for Arthritis (KORONA) database were examined at baseline and for 3 consecutive years using the disease activity score 28 (DAS28), health assessment questionnaire (HAQ), and health-related outcomes. Within a subgroup with active disease (DAS28 ≥ 3.2) at baseline, sex impacts on clinical outcome during a 3-year period were analyzed using generalized estimating equation (GEE) models. The sex effect on achieving clinical remission was analyzed using Cox-proportional hazard regression.
Results

At baseline, women (n = 4,574) were younger and had more erosive disease and longer disease duration than men (n = 802) with significantly higher scores in DAS28, HAQ, and patient-reported outcomes. The prevalence of interstitial lung disease, cardiovascular disease, and diabetes in men was significantly higher than that of women. In a RA subgroup with active disease at baseline, a GEE analysis demonstrated that sex significantly influenced the rate of change of DAS28 (p = 0.035) over time. In that group, men are associated with achieving DAS28 sustained remission as well as point remission (both p < 0.001).
Conclusion

Most comorbidities were more prevalent in men than in women among Korean patients with RA. However, for RA-related clinical outcomes, the longitudinal change in disease activity and the rate of achieving clinical remission were found to be worse in women RA. Therefore, sex-related differences should be considered when managing RA patients.
Direction-of-Arrival Method Based on Randomize-Then-Optimize Approach
Authors: Tang Caiyi , Wang Qianli , Zhao Zhiqin , Nie Zaiping , Niu Chuanfeng 
Published: May 2020

Abstract
Sparse Bayesian learning (SBL) has been successfully applied in solving the problem of direction-of-arrival (DOA) estimation. However, SBL needs multiple snapshots to ensure accuracy and costs huge computational workload. To reduce the requirement of snapshot and computational burden, a DOA estimation method based on the randomize-then-optimize (RTO) algorithm is first time introduced. RTO algorithm uses the optimization and Metropolis-Hastings approach to avoid the “learning” process of SBL in updating hyperparameters. And in order to apply RTO algorithm in the circumstance of signal with Laplace prior, a prior transformation technique is first induced. Compared with conventional CS based DOA methods, the proposed method has a better accuracy with single snapshot and shorter processing time. Some simulations are conducted to demonstrate the effectiveness of the proposed method.