bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical practice guidelines methods to reach diagnostic test recommendations regarding diagnostic laparoscopy for endometriosis: A scoping review
Authors: Zela-Coila Frank , Quispe-Vicuña Carlos , Nuñez-Lupaca Janeth N. , Aparicio-Curazi Milagros , Goicochea-Lugo Sergio 
Published: December 2024

Introduction
Although Clinical Practice Guidelines (CPG) highlight that laparoscopy is often used in the treatment of endometriosis, its diagnostic usefulness is not fully defined. Our objective was to evaluate the quality of CPGs for endometriosis that address the use of diagnostic laparoscopy in reproductive age women, and describe the recommendations and methods used to assess diagnostic test questions.

Methods
A comprehensive search of 5 databases (Trip Database, MEDLINE/PubMed, Web of Science, SCOPUS, and EMABSE) and websites of guideline development organizations and compilers was conducted from 2017 to 2023. A descriptive analysis of the recommendations was performed and the quality of the guidelines was assessed using the AGREE-II instrument.

Results
Four CPGs were included in the review, all exhibiting adequate methodological quality (scores ranging from 66.7% to 91.0%). Regarding the use of laparoscopy for endometriosis diagnosis, discrepancies in recommendations were observed. Two guidelines advised against it, one recommended either laparoscopy or medical empirical treatment, and one favored its use. GRADE guidance was employed for evidence assessment, but only one guideline transparently reported the certainty of evidence and the evidence-to-decision framework process.

Conclusions
Variability in recommendations among different CPGs were found. To keep in mind, discrepancies arise from differing prioritizations of the assessment of clinical impact in patient important outcomes and methodological approaches. This underscores the need for more standardized and transparent guideline development processes, particularly in addressing the clinical utility of diagnostic tests.
Spatial analysis of cholangiocarcinoma in Thailand from 2012 to 2021; a population-based cancer registries study
Authors: Sahat Oraya , Kamsa-ard Supot , Suwannatrai Apiporn Thinkhamrop , Lim Apiradee , Kamsa-ard Siriporn , Bilheem Surichai , Daoprasert Karnchana , Leklob Atit , Uadrang Surin , Santong Chalongpon , Sriket Nithima , Chansaard Wasan 
Published: December 2024

Background
Cholangiocarcinoma (CCA) is major health issue in Thailand, with high incidences in different parts of country. This study examines the association between spatial variables and CCA in Thailand.

Methods
Thailand’s four population-based cancer registries provided data for this retrospective cohort analysis between January 1, 2012, and December 31, 2021. 6,379 diagnosed CCA cases were found in 554 sub-districts. Moran’s I and Local Indicators of Spatial Association (LISA) measured geographic dispersion and estimated sex age-standardized rates (ASRs). Multivariable log-linear regression assessed geography and CCA, calculating adjusted incidence rate ratios (IRRs) and 95% confidence interval (CI).

Results
Of 6,379 CCA cases, 63.9% were male, and the mean age at diagnosis was 66.2 years (standard deviation = 11.07 years). CCA ASRs for both sexes in Thailand was 8.9 per 100,000 person-years. The northeastern region had the greatest ASR at 13.4 per 100 000 person-years. Moran’s I and LISA studies grouped regions by spatial variables. The association between spatial variables and CCA demonstrated that the northern region exhibited elevation (adjusted IRRs = 0.82, 95%CI: 0.78 to 0.87) and distance from water sources variable (adjusted IRRs = 0.91, 95%CI: 0.82 to 0.99). The central region elevation variable (adjusted IRRs = 0.85, 95%CI: 0.76 to 0.94). This was the distance from water sources (adjusted IRRs = 0.96, 95%CI: 0.93 to 0.99) and population density variable (adjusted IRRs = 0.94, 95%CI: 0.93 to 0.96) in the northeastern region. Population density (adjusted IRRs = 1.09, 95%CI: 1.02 to 1.15) and average temperature variable (adjusted IRRs = 1.05, 95%CI: 1.02 to 1.09) were significant in the southern region.

Conclusion
Spatial variables associated with CCA indicate that ASR differs across Thailand. So environmental and climate factors can inform targeted public health strategies to address CCA in high-risk areas throughout Thailand.
Accuracy of the diagnosis of pneumonia in Canadian pediatric emergency departments: A prospective cohort study
Authors: Robinson Joan L. , Kellner James D. , Crotts Jennifer , Travassos Gabino , Chen Guanmin , Kirk Valerie G. , Pusic Martin , Reed Martin , Reid Sarah , Weinstein Michael , Bhargava Ravi , Bhatt Maala , Boutis Kathy , Curtis Sarah , Gouin Serge , Lynch Tim , van Wylick Richard , Johnson David W. 
Published: December 2024

Background
The diagnosis of pediatric pneumonia and determination of the likely pathogen are complicated as the clinical picture overlaps with other respiratory illnesses, interpretation of radiographs is subjective, and laboratory results are rarely diagnostic. This study was designed to describe the relative rates of bacterial and viral pneumonia in the pediatric Emergency Department (ED), determine the accuracy of pediatric ED physicians’ ability to diagnose pneumonia and distinguish bacterial from viral etiology, and to determine clinical and laboratory predictors of bacterial pneumonia.

Methods
Children 3 months to 16 years of age presenting to seven Canadian pediatric EDs before the COVID-19 pandemic with fever and cough who had a chest radiograph performed for possible pneumonia were enrolled and underwent standardized clinical investigations. An expert panel was convened and reached a Consensus Diagnosis of typical or atypical bacterial pneumonia, viral pneumonia or not pneumonia for each case.

Results
The expert panel assessed 247 cases with the Consensus Diagnosis being typical bacterial pneumonia (N = 44(18%)), atypical bacterial pneumonia (N = 18(7%)), viral pneumonia (N = 46(19%)) and no pneumonia (N = 139(56%)). Treating ED physician diagnoses were typical bacterial pneumonia (N = 126(51%)), atypical bacterial pneumonia (N = 3(1%)), viral pneumonia (N = 10(4%)) and no pneumonia (N = 108(44%)) with low agreement between a diagnosis of bacterial pneumonia by the ED physician and the panel’s Consensus Diagnosis (Kappa 0.15 (95% CI 0.08, 0.21)). Cut off values that predicted bacterial pneumonia as the Consensus Diagnosis were ESR ≥ 47 mm/hour, CRP ≥ 42 mg/L and procalcitonin ≥0.85 ng/m. Age greater than 5 years and cough for 5 or more days also predict bacterial pneumonia.

Conclusion
In this cohort, pediatric ED physicians over-diagnosed typical bacterial pneumonia and underdiagnosed viral and atypical bacterial pneumonia. Bacterial pneumonia is most likely in children over 5 years of age, with cough for 5 or more days and/or with elevated inflammatory markers.
CLIP-based multimodal endorectal ultrasound enhances prediction of neoadjuvant chemoradiotherapy response in locally advanced rectal cancer
Authors: Zhang Hanchen , Yi Hang , Qin Si , Liu Xiaoyin , Liu Guangjian 
Published: December 2024

Background
Forecasting the patient’s response to neoadjuvant chemoradiotherapy (nCRT) is crucial for managing locally advanced rectal cancer (LARC). This study investigates whether a predictive model using image-text features extracted from endorectal ultrasound (ERUS) via Contrastive Language-Image Pretraining (CLIP) can predict tumor regression grade (TRG) before nCRT.

Methods
A retrospective analysis of 577 LARC patients who received nCRT followed by surgery was conducted from January 2018 to December 2023. ERUS scans and TRG were used to assess nCRT response, categorizing patients into good (TRG 0) and poor (TRG 1–3) responders. Image and text features were extracted using the ResNet50+RBT3 (RN50) and ViT-B/16+RoBERTa-wwm (VB16) components of the Chinese-CLIP model. LightGBM was used for model construction and comparison. A subset of 100 patients from each responder group was used to compare the CLIP method with manual radiomics methods (logistic regression, support vector machines, and random forest). SHapley Additive exPlanations (SHAP) technique was used to analyze feature contributions.

Results
The RN50 and VB16 models achieved AUROC scores of 0.928 (95% CI: 0.90–0.96) and 0.900 (95% CI: 0.86–0.93), respectively, outperforming manual radiomics methods. SHAP analysis indicated that image features dominated the RN50 model, while both image and text features were significant in the VB16 model.

Conclusions
The CLIP-based predictive model using ERUS image-text features and LightGBM showed potential for improving personalized treatment strategies. However, this study is limited by its retrospective design and single-center data.
Health literacy: a new challenge for laboratory medicine
Authors: Pennestrì Federico , Banfi Giuseppe 
Published: December 2024

Abstract
Poor health literacy and inappropriate test prescribing hamper the value of laboratory medicine. The disintermediation between test producers and interpreters may happen both in Point of Care Tests, where doctor mediation is provided, but laboratory expert supervision is not, and in Direct to Consumer Testing, where no medical mediation is provided at all. In these cases, the respect for patient’s autonomy must not preclude the principles of non-maleficence (as an individual concern) and justice (as a societal concern), as wrong test interpretation can generate confusion, anxiety, inappropriate social behavior, useless medical examinations and considerable cost increase. Considering how different is patient ability to understand test results (if any) and handle any physical and psychological consequence, promoting health literacy and professional laboratory mediation become crucial professional priorities. The aims of this review are 1) to describe the importance of health literacy on laboratory test interpretation, medical advice and therapeutic compliance; 2) to discuss doctor-level, patient-level and caregiver-level educational interventions in light of the four principles of the value-based framework (personal value, technical value, allocative value and societal value). Based on these premises, the authors support the need to enhance health literacy in patients, help doctors improve the communication of results and validate commercial tests under the scrutiny of scientific community.
Efficient and stable to coking catalysts of ethanol steam reforming comprised of Ni + Ru loaded on MgAl2O4 + LnFe0.7Ni0.3O3 (Ln = La, Pr) nanocomposites prepared via cost-effective procedure with Pluronic P123 copolymer
Authors: Massalimova Bakytgul , Sadykov Vladislav , Totenova Nurzada , Fedorova Julia , Glazneva Tatyana , Krieger Tamara , Rogov Vladimir , Ishchenko Arkady 
Published: December 2024

Abstract
Mesoporous MgAl2O4 + LnFe0.7Ni0.3O3 (Ln = La, Pr) nanocomposites were prepared by a cost-effective one-pot procedure with the Pluronic P123 copolymer and Ni + Ru active components were supported on them by wet impregnation. The real structure of samples was studied by X-ray diffraction and transmission electron microscopy with energy-dispersive X-ray spectroscopy, surface properties were determined by Fourier transform infrared spectroscopy of adsorbed CO, reactivity was evaluated by temperature programmed reduction by H2, and catalytic activity was tested in ethanol steam reforming (ESR). Disordering of the real structure of nanocomposite supports due to incorporation of transition metal cations into MgAl2O4 results in the development of a metal–support interface and domination of single surface metal centers. This provides a high catalytic activity in the ESR reaction in the intermediate temperature range ∼550°C, close to that of the best known catalysts, and stability to coking. A higher activity for the Pr-containing catalyst is provided by the high reactivity of surface oxygen species bound with Pr cations.
FEM for improvement of damage prediction of airfield flexible pavements on soft and stiff subgrade under various heavy load configurations of landing gear of new generation aircraft
Authors: Ambassa Zoa , Cyprien Felix Ossende Owona 
Published: December 2024

Abstract
This study establishes the state-of-the-art requirements verification process applied to compute the damage of flexible airfield pavement from new French rational method. Flexible pavement structures with platforms A, B, C, and D, recommended by International Civil Aviation Organization (ICAO), were modelled under static loading of bogies from heavy weight aircrafts A340, B777, and A380 using Cast3M 3D finite element modelling. From the results of these computations, it appears that these structures A, B, C, and D recommended by ICAO are not equivalent from the point of view of mechanical behaviour as claimed by the empirical method for the design of aeronautical bituminous pavements with abacus. The representation of the strain shapes was done with 3D and 2D profiles to improve the quality of response and to clearly identify the critical areas when an aircraft bogie is passing. The four- and six-wheels bogies of the aircraft A380 are more destructive to flexible pavements than the bogies of the other aircrafts tested in this study. The calculation of damage according to the new French rational method for aeronautical flexible pavements revealed that the main damage to these pavements is due to the fatigue of the bituminous layers and not the rutting of subgrade and the unbound granular material layers.
Yet Another Heuristic: Assessing Eudaimon versus Makarios in Aristotle’s Nicomachean Ethics
Authors: Boor Kelsey 
Published: December 2024

Abstract
This paper discusses the debate regarding the terms makarios (“blessed”) and eudaimon (“happy”) in Aristotle’s Nicomachean Ethics. In it, I identify two scholarly conclusions regarding these terms: (1) the distinction thesis: that the words mean different things in the text, and (2) the interchangeability thesis: that the words do not mean different things in the text, and may be substituted for one another. I argue that the theories should both be used as heuristic tools of analysis, rather than only one of them being used as a universal rule to be applied to the text. Additionally, I argue that a third heuristic device is needed: I forward that while makarios and eudaimon are sometimes interchangeable (contra the distinction thesis) they are not synonymous (contra the interchangeability thesis). Rather, in some cases, both terms can be translated as “happy,” but they are being used by Aristotle in reference to subjects with distinct natures. In these instances, eudaimonia can sometimes be interpreted as a properly human term, which we cannot apply to the gods. Or, if it is applied to the gods, it must be applied in a distinct, qualified way. Meanwhile, makarios can sometimes be interpreted as a properly divine term, used in reference to the gods or to a god-like status achieved by a human being who has superseded normal human achievement or capacity.
L’interpretazione dei proemi dei dialoghi nel Commento all’Alcibiade I di Proclo
Authors: Motta Anna 
Published: December 2024

Abstract
The aim of this paper, which is devoted to the Proclean Commentary on the Alcibiades I, is to explain not only why this dialogue is so popular in Neoplatonism, i.e. why it is considered the foundation of Plato’s teaching, but also its methodological importance for reading the proems of the dialogues. For, in my opinion, it has not yet been properly investigated whether and why the two issues, i.e. the introductory importance and the importance for grasping the relevance of the proems, are closely linked. I will therefore first try to show how the isagogical questions are perfectly embedded in a philosophical system that has redefined the very criteria of textual analysis around the idea that each dialogue is a literary microcosm analogous to the macrocosmic universe. I will then show how the exegetical methods proposed by Proclus in his Commentary on the Alcibiades are influenced by certain theoretical assumptions that are useful for reading the dialogues in general, and finally I will demonstrate how the proem of the Alcibiades allows us to re-evaluate the importance of the proems that Plato appended to his writings.
Economics, supply chain and advanced tolerance fuel requirement of very small modular reactors (vSMR): a case study for Saudi Arabia
Authors: Khan Salah Ud‐Din 
Published: December 2024

Abstract
The Kingdom of Saudi Arabia (KSA) is now among the few nations poised to benefit from nuclear reactor technology. For building nuclear reactors in a desert region like the Kingdom, one of the effective approach is to construct small nuclear power plants that can be swiftly deployed in remote areas. Key factors include the performance of these nuclear reactors, which encompasses their innovative design, safe operation, and economic viability. The research begins with a comprehensive analysis of the latest literature on very small modular reactors (vSMRs), including relevant policies and regulations. The reactors’ suitability for Saudi Arabia’s climate is also assessed. Considering the country’s extensive sustainable energy plan, the future energy market in Saudi Arabia is examined. The study covers the gasoline supply chain system, addressing both the front and back ends, safety features, development strategies, and implementation challenges. Additionally, technological advancements relevant to Saudi Arabia, such as control systems, computer platforms, and fuel tolerance during accidents, are explored. The research supports considering vSMRs as a viable addition to the nuclear fleet of KSA.
Improvement of cocoa powder properties through ultrasonic- and microwave-assisted alkalization
Authors: Muhammad Dimas Rahadian Aji , Pratama Dion , Praseptiangga Danar , Ariviani Setyaningrum , Adan Mary Faith , Putri Sastia Prama , Fukusaki Eiichiro 
Published: December 2024

Abstract
Improving the process efficiency is still a challenge in the alkalization process of cocoa powder. This research aims to study the effect of ultrasonic- and microwave-assisted alkalization on the quality attributes of cocoa powder. Three levels of process duration were used (5, 10, and 15 min), and then the physical and antioxidant properties of the cocoa powder were evaluated. The results show that ultrasonic- and microwave-assisted alkalization is more effective in improving cocoa powder’s darkness and red intensity than the conventional alkalization process. The cocoa powder produced using ultrasonic- and microwave-assisted alkalization significantly improved the pH to 7.59, solubility from 20 to 28% and wetting time to almost twice, depending on the type and duration of the process. However, both advanced methods caused a significant decrease in total phenols, flavonoids, and antioxidant activity by about 35, 22, and 38%, respectively, compared to the conventional method. This research provides further information on the potential use of ultrasonication and microwave techniques, particularly in cocoa powder processing that has not been explored previously.
O papel do cuidador formal de idosos: facilidades e dificuldades no exercício do cuidado / The role of the elderly formal caregiver: facilities and difficulties in the exercise of care
Authors: Fernandes Aline da Rocha Kallás , Araujo Meiriele Tavares , Mattar e Silva Tauana Wazir , Velloso Isabela Silva Cancio 
Published: December 2024

Objetivo: conhecer os desafios vivenciados pelos cuidadores formais nas práticas cotidianas do cuidado ao idoso. Método: estudo descritivo-exploratório, cujas entrevistas foram realizadas entre dezembro de 2016 e maio de 2017 com 18 cuidadores formais, captados a partir da associação de cuidadores do estado de Minas Gerais seguido da técnica de bola de neve, e analisadas a luz da análise de conteúdo. Resultados: foram encontradas três categorias temáticas: Papel da enfermagem para a prática cotidiana do cuidador formal de idosos, limites (in)visíveis do cuidado ao idoso entre os cuidadores de idosos e a enfermagem, e cuidador visto como profissionais da enfermagem - autopercepção do cuidador. Conclusões: a crescente demanda por cuidados ao idoso e a busca por recursos torna necessário a delimitação de atuações que garanta sua qualidade e o exercício legal da profissão do cuidador como uma velha-nova ocupação que comprime atividades de vários profissionais, principalmente da enfermagem. Devido a migração para o sistema OJS3, a íntegra desse artigo pode ser acessado pelo seguinte endereço eletrônico: O papel do cuidador formal de idosos: facilidades e dificuldades no exercício do cuidado | Journal of Nursing and Health (ufpel.edu.br)
A Educação para a sustentabilidade como elemento de fortalecimento da economia solidária e da agroecologia: o trabalho da INCUBACOOP/UFRPE em Bonito-PE
Authors: Dubeux Ana , Vasconcelos Gilvania de Oliveira Silva de , Souza Beatriz Pessoa de 
Published: December 2024

O presente trabalho está vinculado à ação de incubação territorial desenvolvida pela Incubadora Tecnológica de Cooperativas Populares – INCUBACOOP, do Departamento de Educação, da Universidade Federal Rural de Pernambuco – DEd/UFRPE, que em 2019 festejou seus 20 anos. A incubadora desenvolve um trabalho desde 2016 no município de Bonito - PE que visa criar novas possibilidades na metodologia de incubação. Em seus 20 anos de existência, a incubadora já passou por algumas fases em termos metodológicos e o presente texto busca apresentar este amadurecimento a partir de um trabalho de educação para sustentabilidade. A formação dos educadores e de monitores ambientais são elementos essenciais para a promoção da educação para a sustentabilidade, elemento de fortalecimento da educação do campo, que promove a transformação social a partir dos sujeitos do campo. Busca-se ainda, demonstrar como a educação para a sustentabilidade é essencial no fortalecimento da metodologia de incubação nos territórios aos quais as incubadoras universitárias se vinculam, fortalecendo grupos e iniciativas de agroecologia e economia solidária.Palavras-chave: educação para sustentabilidade; agroecologia; economia solidária; incubação; desenvolvimento territorial. Abstract: This article is linked to the territorial incubation action developed by the Technological Incubator of Popular Cooperatives - INCUBACOOP, of the Department of Education, of the Federal Rural University of Pernambuco - DEd / UFRPE, which in 2019 celebrated its 20 years. The incubator has been developing an action since 2016 in the municipality of Bonito - PE that aims to test new possibilities in the incubation methodology. In its 20 years of existence, the incubator has gone through some phases in methodological terms and this analysis seeks to present this maturity based on a work of education for sustainability developed in that municipality. The training process of educators and environmental monitors are essential elements for the promotion of education for sustainability, an element of strengthening rural education, which promotes social transformation from the subjects of the countryside. It also seeks to demonstrate how education for sustainability is essential in strengthening the incubation methodology in the territories to which university incubators are attached, strengthening groups and initiatives of agroecology and solidarity economy.Keywords: education for sustainability; agroecology; solidarity economy; incubation territorial development.