bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS STRATEGI PEMASARAN DALAM PENGEMBANGAN USAHA SUKASIHSHOP
Authors: Sukasih Emiliana , Rini Hapsari Veneranda , S.E.,M.M Usman, 
Published: December 2024

Tujuan dari penelitian ini adalah untuk memahami analisis strategi penempatan produk dalam pertumbuhan Sukasihshop dalam kaitannya dengan loyalitas pelanggan. Penelitian ini dilakukan pada usaha SukasihShop yang berlokasi di Bengkayang Barat. Penelitian ini menggunakan desain penelitian kualitatif dengan metodologi penelitian kepustakaan. Teknik pengumpulan data dilakukan melalui observasi, angket dan komentar. E-Commerce merupakan sebuah platform dimana pertemuan antara penjual dan pembeli dapat terjadi secara tidak langsung (Andriyanty & Lestari, 2022). Dimana e-commerce memegang peranan penting dalam proses penjualan dan pembelian, dimana kegiatan ini melibatkan banyak pihak. Dapat juga dipahami dari sebuah konsep penjualan bahwa e-commerce termasuk dalam e-business. Dimana e-commerce merupakan inisiatif terbaik bagi sebuah bisnis, dan dengan e-commerce yang lebih baik maka diyakini suatu bisnis akan sukses karena telah memenuhi keinginan pasar. Diketahui pula bahwa e-commerce dapat menghubungkan banyak orang dari berbagai tempat melalui media yang sama. Dengan e-commerce yang lebih baik, diyakini suatu bisnis akan berhasil karena telah memenuhi keinginan pasar. Diketahui pula bahwa e-commerce dapat menghubungkan banyak orang dari berbagai tempat melalui media yang sama
Kata kunci: Pengenbangan Usaha, Pemasaran, Strategi
Tuberculosis Detection based on Lung X-Ray Images Using Convolutional Neural Networks (CNN)
Authors: Kurniawan Rudi , Badriyah Tessy , Syarif Iwan 
Published: December 2024

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, primarily affecting the lungs. Despite being preventable and curable, TB remains a significant global health issue, especially in developing countries. The success of TB treatment heavily depends on the accuracy of the diagnosis, which typically requires expertise from pulmonology or radiology specialists to interpret chest X-ray images. This study aims to design an assistive tool for TB detection that can automatically diagnose the disease using chest X-ray data. The study implemented a Convolutional Neural Network (CNN) architecture to analyze the X-ray images. Additionally, image preprocessing and early stopping methods were employed to enhance accuracy performance, optimize computation, and prevent overfitting. Experiment was conducting using 75% of the data as training data to generate the model and then applied to 25% of the data as testing data. This study comparing image sizes in RGB and grayscale modes. Experimental results show that the use of early stopping has a significant impact on training time, reducing training time substantially in almost all scenarios without drastically sacrificing accuracy. Without early stopping, accuracy does tend to be higher, as seen in grayscale color mode with an image size of 128x128, where the accuracy reaches 0.992, and in RGB mode with an image size of 64x64 which reaches 0.995. However, training time also increases significantly, for example for a 299x299 image with RGB mode, the training time reaches 927 seconds. Therefore, while RGB yields slightly higher accuracy, grayscale is recommended due to significantly faster training times. Additionally, the early stopping mechanism proves effective in reducing computational time, making the training process more efficient.
Factors Affecting Successful Creation of Arterio-venous Fistula for Hemodialysis
Authors: SMG Saklayen  , Laila Akter Zahan  , Rusama Nuzhat  , Wahidul Azad Polash  , Lulu Marzan Hashi  
Published: December 2024

The preferred vascular access method for efficient hemodialysis is the arterio-venous fistula (AVF). There is a rising trend in AVF establishment conducted by nephrologists, aiming to alleviate the workload of vascular surgeons and expedite the prompt care of individuals afflicted with end-stage renal disease (ESRD). This descriptive observational study was conducted at the Department of Vascular Surgery, Ibrahim Cardiac Hospital and Research Institute during the period of June 2017 to July 2022. During the data collection period 1700 patients sought care in the Department for arterio-venous fistula creation, among them complete data of 1103 patients were included in this study. Majority of chronic kidney disease (CKD) patients were referred from the Department of Nephrology, BIRDEM for AVF creation in the mentioned timeline. Data were collected pre-designed data collection sheet and data were analyzed using Statistical Package for Social Sciences (SPSS) version- 25. This study shows that most of the patients (80.8%) were in ages 30 - 59 years and more than two-third (67.6%) of them were male; male-female ratio was 2:1. Diabetes mellitus (DM) was detected in nearly half of the patients (47.2%) and more than two-third (67.2%) of them were suffering from hypertension (HTN). Higher failure rate (73.3%) of AVF creation among patients of age group 30-59 years was significant. Failure rate for male patients was 57% and female patients was 43%. The AVF creation failure rates were 100% for patients with hypertension and for diabetes patients was 60.5%. Complications were found in 15.2% of patients. Post-operative edema and hematoma formation were more common (3.2% and 3.5%, respectively) in comparison to other complications. Among the complicated cases, 7 patients (4.2%) required intervention to correct stealing syndrome and AVF salvage was attempted in 43 cases (25.6%); medical management was pursued in 32(19.0%) cases. Majority (51.2%) of cases who were experiencing complications required AVF ligation. This research demonstrates that several significant clinical factors influence the successful establishment of an arterio-venous fistula (AVF) for hemodialysis factors include advanced age, being male, having diabetes (DM) and hypertension (HTN), having a history of Maintenance Hemodialysis (MHD) prior to AVF creation, choosing the wrist or arm as the AVF site, utilizing specific veins (cephalic and basilic) and specific arteries (radial and brachial).
Bangladesh Med J. 2023 Sept; 52(3): 1-7
Diagnosis value of targeted and metagenomic sequencing in respiratory tract infection
Authors: Kuang Yukun , Tan Weiping , Hu Chaohui , Dai Zehan , Bai Lihong , Wang Jiyu , Liao Huai , Chen Haihong , He Rongling , Zhu Pengyuan , Liu Jun , Xie Canmao , Ke Zunfu , Tang Ke-Jing 
Published: December 2024

BackgroundTargeted next-generation sequencing (tNGS) has become a trending tool in the field of infection diagnosis, but concerns are also raising about its performance compared with metagenomic next-generation sequencing (mNGS). This study aims to explore the clinical feasibility of a tNGS panel for respiratory tract infection diagnosis and compare it with mNGS in the same cohort of inpatients.Methods180 bronchoalveolar lavage fluid samples were collected and sent to two centers for mNGS and tNGS blinded tests, respectively. The concordance between pathogen reports of both methods and the clinical significance among samples with/without known etiology was further evaluated.ResultsOverall, both methods displayed high agreement on pathogen reports, as the average percent agreement reached 95.29%. But tNGS presented a slightly higher detection rate per species than mNGS (PWilcoxon=1.212e-05; standard mean difference = 0.2887091), as detection rates for 32 out of 48 species were higher than those of mNGS. Due to limitations of panel coverage, tNGS identified 28 fewer species than mNGS, among which only 3 were considered clinically relevant. In reference to composite reference standard, accuracy, sensitivity, and specificity combining both tNGS and mNGS reached 95.61%, 96.71%, and 95.68%, respectively, while positive prediction value (PPV) was low at 48.13%, which was caused by low agreement regarding opportunistic pathogens. tNGS and mNGS improved the etiology identification in 30.6% (55/180) and 33.9% (61/180) cases, respectively.ConclusionCollectively, tNGS presented a similar overall performance in pathogen identification compared to mNGS, but outperformed in some pathogens. This study also demonstrated that deployment of tNGS significantly improves etiology identification in routine practice and provides hints for clinical decisions. The low agreement between clinical diagnosis and NGS reports towards opportunistic pathogens implies that adjudication is essential for report interpretation. Finally, We proposed tNGS as a diagnosis option in clinical practice due to its cost-efficiency.
Long-term patient-reported outcomes following congenital heart surgery in adults
Authors: Schaeffer Thibault , Bossers Pauline , Kienmoser Doris , Tutarel Oktay , Heinisch Paul Philipp , Ono Masamichi , Cleuziou Julie , Pabst von Ohain Jelena , Hörer Jürgen 
Published: December 2024

ObjectiveTo investigate the long-term impact of cardiac surgery on the quality of life in adults with congenital heart disease (ACHDs).MethodsPatients who had undergone cardiac surgery for congenital heart disease (CHD) at the age of 18 years or more were recruited in a single-center, cross-sectional study. The enrolled subjects completed online questionnaires to assess patient-reported outcomes: perceived health status and life satisfaction, psychological functioning, health behaviors, and illness perception. Clinical variables were correlated to the score results, and results were compared to representative samples from international and German national surveys of healthy subjects and ACHDs.ResultsWe enrolled 196 ACHDs (54% women), including 55% with more than one cardiac surgery during their lifetime. The median age at the survey was 43 years, with a median of 13 years since their last cardiac surgery. The majority of patients reported improved subjective wellbeing after cardiac operation and were in functional New York Heart Association class I or II. The severity of underlying CHD, number of previous cardiac operations, and beta-blocker medication had the most substantial negative effects on illness perception. Measured quality of life and health risk behaviors were within the range of values internationally reported for healthy and CHD subjects, respectively.ConclusionsACHD, several years after cardiac surgery, reported a subjective improvement in their wellbeing, a life satisfaction comparable to that of healthy individuals, and low health risk behaviors. Illness perception is strongly correlated with the severity of the underlying CHD.
A systematic review of features and content quality of Arabic mental mHealth apps
Authors: Alnaghaimshi Noorah Ibrahim S. , Awadalla Mona S. , Clark Scott R. , Baumert Mathias 
Published: December 2024

IntroductionAnxiety and depression are major causes of disability in Arab countries, yet resources for mental health services are insufficient. Mobile devices may improve mental health care delivery (mental m-Health), but the Arab region's mental m-Health app landscape remains under-documented. This study aims to systematically assess the features, quality, and digital safety of mental m-Health apps available in the Arab marketplace. We also contrast a set of recommended Australian apps to benchmark current strategies and evidence-based practices and suggest areas for improvement in Arabic apps.MethodsFifteen Arab country-specific iOS Apple Stores and an Android Google Play Store were searched. Apps that met the inclusion criteria were downloaded and evaluated using the Mobile App Rating Scale (MARS) and the Mobile App Development and Assessment Guide (MAG).ResultsTwenty-two apps met the inclusion criteria. The majority of apps showed no evidence of mental health experts being involved in the app design processes. Most apps offered real-time communication with specialists through video, text, or audio calls rather than evidence-based self-help techniques. Standardized quality assessment showed low scores for design features related to engagement, information, safety, security, privacy, usability, transparency, and technical support. In comparison to apps available in Australia, Arabic apps did not include evidence-based interventions like CBT, self-help tools and crisis-specific resources, including a suicide support hotline and emergency numbers.DiscussionIn conclusion, dedicated frameworks and strategies are required to facilitate the effective development, validation, and uptake of Arabic mental mHealth apps. Involving end users and healthcare professionals in the design process may help improve app quality, dependability, and efficacy.
Potential candidates from a functional food Zanthoxyli Pericarpium (Sichuan pepper) for the management of hyperuricemia: high-through virtual screening, network pharmacology and dynamics simulations
Authors: Chen Meilin , Chen Xiaomei , Chen Qinghong , Chu Chenyang , Yang Shuxuan , Wu Chuanghai , You Yanting , Hung Andrew , Yang Angela Wei Hong , Sun Xiaomin , Zhou Lin , Zhao Xiaoshan , Li Hong , Liu Yanyan 
Published: December 2024

IntroductionHyperuricemia (HUA) is a metabolic syndrome caused by purine metabolism disorders. Zanthoxyli Pericarpium (ZP) is a medicinal and food homologous plant, and its ripe peel is used to treat diseases and as a spice for cooking. Some studies have shown that ZP can inhibit the formation of xanthine oxidase and reduce the production of uric acid.MethodsThrough network pharmacology, ZP’s potential targets and mechanisms for HUA treatment were identified. Databases like TCMSP, UniProt, and Swiss Target Prediction were utilized for ZP’s active ingredients and targets. HUA-related targets were filtered using GeneCards, Drugbank, and Open Targets. Core targets for ZP’s HUA treatment were mapped in a PPI network and analyzed with Cytoscape. GO and KEGG pathway enrichments were conducted on intersected targets via DAVID. Molecular docking and virtual screening were performed to find optimal binding pockets, and ADMET screening assessed compound safety. Molecular dynamics simulations confirmed compound stability in binding sites.ResultsWe identified 81 ZP active ingredient targets, 140 HUA-related targets, and 6 drug targets, with xanthine dehydrogenase (XDH) as the top core target. Molecular docking revealed ZP’s active ingredients had strong binding to XDH. Virtual screening via Protein plus identified 48 compounds near the optimal binding pocket, with 2’-methylacetophenone, ledol, beta-sitosterol, and ethyl geranate as the most promising. Molecular dynamics simulations confirmed binding stability, suggesting ZP’s potential in HUA prevention and the need for further experimental validation.ConclusionOur study provides foundations for exploring the mechanism of the lowering of uric acid by ZP and developing new products of ZP. The role of ZP in the diet may provide a new dietary strategy for the prevention of HUA, and more experimental studies are needed to confirm our results in the future.
Negative correlation between cardiometabolic index and testosterone in male adults
Authors: Xu Jing , Li Yue-Chun 
Published: December 2024

BackgroundInsulin resistance (IR) is closely correlated with a deficiency or decrease of testosterone levels in males. Cardiometabolic index (CMI) is correlated with various diseases correlated with IR. The primary objective of this study is to explore the correlation between CMI and testosterone levels in male adults.MethodsData from the National Health and Nutrition Examination Survey (NHANES) during the period from 2013 to 2020 were analyzed through a cross-sectional design. CMI was calculated by multiplying waist-to-height ratio (WHtR) with the triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C).ResultsA total of 5012 subjects were included in the final analysis. After controlling confounding variables, multiple linear regression analysis indicated an independent negative correlation between CMI and testosterone levels (β= -6.40, 95% CI: -8.95, -3.86, P&lt;0.001) through the. In addition, a negative non-linear correlation was also found between CMI and testosterone (P&lt;0.05), with CMI’s inflection point as 0.73. Subgroup analyses indicated a more significant negative correlation among those with normal weight and the elderly (p&lt; 0.05 for all interactions). The area under the ROC curve (AUC) of CMI (AUC =0.724, 95% CI: 0.709–0.740) was the largest compared with those of TG/HDL and WHtR.ConclusionElevated CMI is significantly and negatively correlated with testosterone in male adults.
Different supplements improve insulin resistance, hormonal functions, and oxidative stress on overweight and obese women with polycystic ovary syndrome: a systematic review and meta-analysis
Authors: Ren Xiaoyan , Wu Wenjuan , Li Qiufan , Li Wen , Wang Xujuan , Wang Gang 
Published: December 2024

ObjectivesTo investigate various supplements that improve insulin resistance, hormonal status, and oxidative stress in overweight or obese women with polycystic ovarian syndrome (PCOS).MethodsA literature search was conducted on four different databases, which led to the discovery of twenty - five randomized controlled trials (RCTs). These RCTs evaluated the efficacy of various supplements in improving insulin resistance (IR), hormonal status, and oxidative stress among overweight or obese women diagnosed with PCOS. Subsequently, data extraction and analysis were carried out to determine the quality of the study’s methodological design and the potential for bias. Moreover, a meta-analysis was performed using the data from the RCTs.ResultsA total of 25 RCTs were carried out, and 1636 women were enrolled. All participants were overweight or obese. The standardized mean differences (SMD) were as follows: For fasting plasma glucose (FPG), it was -0.34 (95% confidence interval [CI], -0.49 to -0.19, p = 0.123, I2 = 30.8%); for insulin, it was -0.67 (95% CI, -0.83 to -0.52, p = 0.208, I2 = 24%); for fasting insulin (FI), it was -0.26 (95% CI, -0.52 to -0.00, p = 0.269, I2 = 21.9%); for homeostatic model assessment-insulin resistance index (HOMA-IR), it was -0.59 (95% CI, -0.73 to -0.45, p = 0.015, I2 = 48.7%); for homoeostatic model assessment beta - cell function (HOMA-B), it was -0.51 (95% CI, -0.75 to -0.27, p = 0.547, I2 = 0%); for quantitative insulin sensitivity check index (QUICKI), it was 0.94 (95% CI, 0.76 to -1.12, p = 0.191, I2 = 27.5%); for total testosterone, it was -0.61 (95% CI, -1.14 to -0.09, p = 0.00, I2 = 78.5%); for testosterone, it was -0.38 (95% CI, -0.86 to 0.10, p = 0.03, I2 = 71.5%); for follicle - stimulating hormone (FSH), it was 0.16 (95% CI, -0.08 to 0.40, p = 0.470, I2 = 0%); for luteinizing hormone (LH), it was -0.56 (95% CI, -1.32 to 0.20, p = 0.000, I2 = 91.1%); for sex hormone - binding globulin (SHBG), it was 0.35 (95% CI, 0.02 to 0.69, p = 0.000, I2 = 78%); for dehydroepiandrosterone (DHEAS), it was -0.27 (95% CI, -0.76 to 0.21, p = 0.001, I2 = 78.7%); for plasma total antioxidant capacity (TAC), it was 0.87 (95% CI, 0.45 to 1.30, p = 0.004, I2 = 71.3%); for plasma malondialdehyde (MDA), it was -0.57 (95% CI, -0.79 to -0.36, p = 0.992, I2 = 0.0%).ConclusionThis study’s findings indicate that, in comparison with a placebo, supplements have a favorable effect on IR, hormonal functions, and oxidative stress in PCOS. Nevertheless, it is crucial to note that the above-drawn conclusions need to be verified by more high-quality studies, given the limitations regarding the number and quality of the included studies.
The development of patient-specific 3D anatomical models in minimally invasive parathyroidectomy
Authors: Haq Zahra J. , Ahmed Ahmed , Abdelsalam Alaa , Chegini Soudeh , Kurzawinski Tom R. , Morley Simon , McGurk Mark , Abdel-Aziz Tarek 
Published: December 2024

BackgroundSurgery is the preferred treatment for primary hyperparathyroidism. Minimally invasive parathyroidectomy is only feasible with accurate preoperative localisation. Virtual 3D anatomical models can be constructed from patient-specific CT scans using segmentation software.MethodsWe aimed to create virtual 3D models from 4D-CT scans of parathyroid tumours using segmentation technology. We designed a small pilot study to assess the utility of 3D models within surgical practice. We assessed surgeon, trainee and patients’ opinion and satisfaction with the models. The NASA TLX survey was the primary data collection toolResultsCreation of novel 3D models was achieved, these featured a 360-degree axis of rotation and transparency mode to assist in surgical planning. Models were used intraoperatively with the HoloLens 2 headset to locate parathyroid tumours real time before surgery. Total mean workloads for surgery planning when averaged revealed a decrease workload (39.45 vs 27.45) points with adjunctive use of models (p=0.002). Mental demand showed the greatest decrease in mean workload out of all the 6 subscales tested for in the NASA TLX (210.3 vs 136.7) points. Patient satisfaction score was statistically significant for the difference before and after seeing the 3D model regarding anatomical location (p=≤0.001),ConclusionIn this work, we developed patient-specific virtual 3D anatomical models of parathyroid tumours for use in surgery using novel techniques, previously never applied to parathyroidectomy. Our initial success in model construction and subsequent opinion of surgeons, trainees and patients contributes to the developing body of literature in favour of virtual modelling for parathyroidectomy.
Microplastic research trends in the Gulf region from a global perspective
Authors: Shabib Ahmad , Reshadi Mir Amir Mohammad , Maraqa Munjed A. , Rezanezhad Fereidoun 
Published: December 2024

IntroductionMicroplastic (MP) pollution research has experienced significant global growth, with an exponential increase in publications since 2015. Despite this surge, research focused on the Gulf region remains limited. This gap is particularly concerning given the Gulf's dense industrial activities and substantial waste production. This study provides the first bibliometric analysis of MP research globally and within the Gulf region, examining the current state and emerging trends while identifying specific topics for future studies.MethodsA bibliometric analysis of peer-reviewed articles published between 2000 and 2024 was conducted for global and Gulf region research. Bibliometric analysis employed several tools to identify trends, keyword networks, and research gaps, with manual refinement of keywords to enhance accuracy. The study also analyzed leading countries and institutions contributing to MP research.Results and DiscussionThe analysis highlights significant global contributions, with China emerging as a leader in MP research globally and Iran playing a prominent role within the Gulf region. While global publications have increased exponentially since 2015, the Gulf region's research output remains underrepresented, accounting for only about 1.1% of global publications. This underscores the need for enhanced regional research to better integrate the Gulf into the global discourse on MPs. Keyword analysis reveals that certain areas of MP research remain unexplored in the Gulf region. The trend analysis shows an evolving focus globally, shifting from basic interactions of MPs with marine environments to more complex issues such as environmental health and ecosystem impacts. This progression indicates a maturing field that increasingly addresses the broader implications of MP pollution.