bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cyclicality of government foreign-aid expenditure: voter awareness in “good” times and in “bad”
Authors: Abbott Andrew , Jones Philip 
Published: December 2019

AbstractWhile it has been argued that the cyclicality of government spending likely depends on the intensities of political pressure to increase expenditure, in economic upturns and downturns, it is important to explore the determinants of changes in the strengths of those pressures. This paper is the first (to our knowledge) to focus on the relevance of systematic changes in voter awareness of government spending. Predictions of the impact of changes in awareness are tested with reference to 23 OECD donor countries’ foreign aid expenditures over the 1999–2015 period. The evidence offers insights into the discretion governments exercise when “fiscal illusion” increases and into the policy implications of systematic changes in voter awareness (in “good” times and in “bad”).
The scope of political jurisdictions and violence: theory and evidence from Africa
Authors: Adamson Jordan 
Published: December 2019

AbstractIs there more violence in areas with many small countries or only a single large one? I build on Bernholz (The international game of power: past, present and future 1985) to create a unifying framework where both internal and external contestants engage in conflict, and then summarize how the spatial configuration of countries affects all types of violence with the Herfindahl–Hirschman Index of state sizes. Empirically, I examine fatalities from the conflict in Africa, where I use the borders set by the colonial powers of Europe to identify the effect of concentration. I find the most fatalities in areas with many small countries, but that violence decreases with concentration at a decreasing rate and eventually increases in areas with only one large country. These findings suggest an important difference between the observed average effect of concentration on violence and the expected marginal effects of further concentration.
The dynamics of collaboration networks and the history of general relativity, 1925–1970
Authors: Lalli Roberto , Howey Riaz , Wintergrün Dirk 
Published: December 2019

AbstractThis paper presents a novel methodology for defining and analyzing the dynamics of the collaboration networks of scientists working on general relativity from the mid-1920s–1970. During these four and a half decades the status of the theory underwent a radical transformation: from a marginal theory before the mid-1950s to a pillar of modern physics. To investigate this passage—known as the renaissance of general relativity—we used a definition of collaboration networks broader than the co-authorship relations retrievable from online datasets. We constructed a multilayer network, in which each layer represents a different kind of collaboration. After having analyzed the evolution over time of specific parameters of the co-authorship network, we investigated the effects of adding one type of collaboration edge at a time, in a cumulative fashion, on the values of these parameters and on the topology of the collaboration network through time, including rapid shifts in the dynamic evolution of the largest component. This analysis provides robust quantitative evidence that a shift in the structure of the relativity collaboration network occurred between the late 1950s and the early 1960s, when a giant component started forming. We interpret this shift as the central social dynamic of the renaissance process and then identify its central actors. Our analysis disproves common explanations of the renaissance process. It shows that this phenomenon was not a consequence of astrophysical discoveries in the 1960s, nor was it a simple by-product of socio-economic transformations in the physics landscape after World War II.
CAR T Cell Therapy for Hematological Malignancies
Authors: Yang Xin , Wang Gao-xiang , Zhou Jian-feng 
Published: December 2019

SummaryAs a rapidly progressing field in oncology, the adoptive transfer of T cells that have been genetically modified with chimeric antigen receptors (CARs) has shown striking efficacy in the management of hematological malignancies and has been reported in a number of clinical trials. Of note, CAR T cell therapy has shown extraordinary potential, especially in relapsed/refractory patients. However, there are still challenges regarding the further development of this strategy, spanning from engineering and manufacturing issues, to limited applications, to accompanying toxicities. In this review, we will summarize the general knowledge of this novel method, including receptor composition, applications, adverse events and challenges. Additionally, we will propose several comprehensive recommendations.
Social security coordination after Brexit: trying to take an egg out of an omelette?
Authors: Roberts Simon 
Published: December 2019

AbstractThis article examines the negotiations to secure social security and healthcare rights after Brexit for people who have exercised their right to free movement or move between the EU and UK in the future. The analysis is based upon examination of drafts of the Withdrawal Agreement informed by interviews with senior policy makers involved in the Brexit negotiations. The article finds that while persons and benefits included in the Withdrawal Agreement mirror those of the current Coordinating Regulations the procedure for identifying eligibility is complicated and future arrangements might not provide comprehensive coverage and legal certainty.
Changes of Population, Built-up Land, and Cropland Exposure to Natural Hazards in China from 1995 to 2015
Authors: Chen Yimin , Xie Wei , Xu Xiaocong 
Published: December 2019

AbstractBy using the latest China population grid and land-use data, we assess the changing exposure of China’s population and land uses to the hazards of storm surges, droughts, earthquakes, floods, and landslides from 1995 to 2015. We found that the single-hazard areas and the multi-hazard areas covered 43% and 26% of China’s territory, respectively. Population grew faster in the hazard-prone areas than in the non-hazard areas. Built-up area expanded more rapidly in the areas prone to earthquakes and landslides. Cropland changed rapidly in many hazard-prone areas. The hazard-prone areas affected by floods featured the highest cropland loss rates, while the areas prone to earthquakes and landslides featured the highest cropland growth rates. We detected areas with significant exposure changes by using hot spot analysis. It was found that population and built-up land in the Pearl River Basin were increasingly exposed to storm surges, floods, and landslides. The Haihe River Basin and Huaihe River Basin also showed a consistent increase of population and built-up land exposure to droughts and earthquakes. These findings can provide a foundation for the design and implementation of protection and adaptation strategies to improve the resilience of Chinese society to natural hazards.
Dynamic simulation of an opencast coal mine: a case study
Authors: Muniappen Kesavan , Genc Bekir 
Published: December 2019

AbstractDynamic simulations are powerful tools, but only if they are developed using the correct methodology, and with information that has been verified. Mining houses rely on simulation to confirm that complex, integrated systems can achieve design capacity before investment decisions are made. Work conducted in the realm of validation can make an invaluable contribution to the success of future projects undertaken around the world. Coal mine a life of mine extension project was approved for implementation when export coal prices were on the low end of the price cycle. The dynamic simulation of the full materials handling value chain conducted during the project feasibility study in 2016 was of utmost importance and provided assurance to the project review team that annual production targets can be achieved. The simulation development methodology was based on a unique approach that reduced time spent on the simulation. Upon completion of project construction and commissioning in 2018, it was essential to validate the simulation, which could lead to the adoption of this approach on future projects. This paper explains the steps taken to validate the dynamic simulation. This case study confirmed that dynamic simulation can add value and predict mining system performance, such that informed decisions can be made.
Designing and Rating Options for Special School Expertise to Support Mainstream Educational Inclusion
Authors: Iacono Teresa , McKinstry Carol , Wilson Elena , Bagley Kerryn , Kenny Amanda 
Published: December 2019

AbstractThe Victorian Government, Australia, committed to deliver recommendations from a review of the Program for Students with Disabilities. We report on the implementation of Recommendation 7: to explore options for how special schools could become ‘centres of expertise’ to support inclusion in mainstream schools. Informed by evidence reviews of inclusive education practices and interviews of special and mainstream staff and parents, stakeholders were engaged in a forum to develop a range of options. A larger sample of stakeholders then completed a survey to evaluate them. Forum attendees were parents, education staff, and allied health professionals from special and mainstream schools. They worked in small groups to develop options, which were later grouped into 5 categories. These options were entered into an online survey for distribution to a wider group of stakeholders. Survey respondents were 142 stakeholders from special (71%) and mainstream primary and secondary schools (parents, education staff, and allied health professionals). They rated each option, such that 8 with high ratings for feasibility and acceptability were recommended to support inclusive mainstream education through utilisation of special school expertise. The final list of options focused on collaboration, development, and coordination of networks of special and mainstream schools, and building capacity and leadership to support mainstream schools to meet diverse student need.
A simple cut-off for waist-to-height ratio (0·5) can act as an indicator for cardiometabolic risk: recent data from adults in the Health Survey for England
Authors: Gibson Sigrid , Ashwell Margaret 
Published: December 2019

AbstractThe National Institute for Health and Care Excellence (NICE) has acknowledged the value of waist-to-height ratio (WHtR) as an indicator for ‘early health risk’. We used recent UK data to explore whether classification based on WHtR identifies more adults at cardiometabolic risk than the ‘matrix’ based on BMI and waist circumference, currently used for screening. Data from the Health Survey for England (4112 adults aged 18+ years) were used to identify cardiometabolic risk, indicated by raised glycated Hb, dyslipidaemia and hypertension. HbA1c, total/HDL-cholesterol and systolic blood pressure (BP) were more strongly associated with WHtR than the ‘matrix’. In logistic regression models for HbA1c ≥ 48 mmol/mol, total/HDL-cholesterol > 4 and hypertension (BP > 140/90 mmHg or on medication), WHtR had a higher predictive value than the ‘matrix’. AUC was significantly greater for WHtR than the ‘matrix’ for raised HbA1c and hypertension. Of adults with raised HbA1c, 15 % would be judged as ‘no increased risk’ using the ‘matrix’ in contrast to 3 % using WHtR < 0·5. For hypertension, comparative values were 23 and 9 %, and for total/HDL-cholesterol > 4, 26 and 13 %. Nearly one-third of the ‘no increased risk’ group in the ‘matrix’ had WHtR ≥ 0·5 and hence could be underdiagnosed for cardiometabolic risk. WHtR has the potential to be a better indicator of cardiometabolic risks associated with central obesity than the current NICE ‘matrix’. The cut-off WHtR 0·5 in early screening translates to a simple message, ‘your waist should be less than half your height’, that allows individuals to be aware of their health risks.
Strongylid infection varies with age, sex, movement and social factors in wild African elephants
Authors: Parker Jenna M. , Goldenberg Shifra Z. , Letitiya David , Wittemyer George 
Published: December 2019

AbstractComparing parasitic infection among individuals of wildlife populations can provide insight into factors that influence wildlife disease ecology. Strongylids are parasitic worms that infect the intestinal tract of vertebrates, and infection with strongylids can be approximated by counting strongylid eggs in dung samples. Here we tested for correlations between strongylid egg counts and 18 different individual characteristics, environmental and social factors in individually known wild African elephants. We counted more eggs in the dung samples of younger elephants and females relative to mature elephants and males. We also found that elephants spending more time outside reserves shed more strongylid eggs than elephants that were more often within reserves. Elephants that were less socially integrated, as measured by how much aggression they received from other elephants, shed fewer strongylid eggs; relatedly, socially isolated orphan elephants that had left their family shed fewer strongylid eggs than elephants that remained with their family. Our results suggest that landscapes altered by livestock grazing and social disruption caused by humans may impact parasitic infection in wildlife.
Recent advances in nucleic acid-based methods for detection of helminth infections and the perspective of biosensors for future development
Authors: Ullah Hanif , Qadeer Abdul , Rashid Muhammad , Rashid Muhammad Imran , Cheng Guofeng 
Published: December 2019

AbstractPathogenic helminth infections are responsible for severe health problems and economic losses worldwide. Timely and accurate diagnosis of helminth infections is critical for adopting suitable strategies for pathogen control. Here, we review recent advances in nucleic acid-based diagnostic methods, including polymerase chain reaction, quantitative qPCR, loop-mediated isothermal amplification and recombinase polymerase amplification, and discuss their advantages and disadvantages for diagnosing helminth infections. In addition, we highlight recent advances in biosensors for the detection of nucleic acid biomarkers that can potentially be used for the diagnosis of helminth infection.
An update on non-invasive urine diagnostics for human-infecting parasitic helminths: what more could be done and how?
Authors: Archer John , LaCourse James E. , Webster Bonnie L. , Stothard J. Russell. 
Published: December 2019

AbstractReliable diagnosis of human helminth infection(s) is essential for ongoing disease surveillance and disease elimination. Current WHO-recommended diagnostic assays are unreliable in low-endemic near-elimination settings and typically involve the invasive, onerous and potentially hazardous sampling of bodily fluids such as stool and blood, as well as tissue via biopsy. In contrast, diagnosis by use of non-invasive urine sampling is generally painless, more convenient and low risk. It negates the need for specialist staff, can usually be obtained immediately upon request and is better accepted by patients. In some instances, urine-based diagnostic assays have also been shown to provide a more reliable diagnosis of infection when compared to traditional methods that require alternative and more invasive bodily samples, particularly in low-endemicity settings. Given these relative benefits, we identify and review current research literature to evaluate whether non-invasive urine sampling is currently exploited to its full potential in the development of diagnostic tools for human helminthiases. Though further development, assessment and validation are needed before their routine use in control programmes, low-cost, rapid and reliable assays capable of detecting transrenal helminth-derived antigens and cell-free DNA show excellent promise for future use at the point-of-care in high-, medium- and even low-endemicity elimination settings.
Second-harmonic generation by a chirped laser pulse with the exponential density ramp profile in the presence of a planar magnetostatic wiggler
Authors: Kant Niti , Singh Arvinder , Thakur Vishal 
Published: December 2019

AbstractSecond-harmonic generation of the relativistic self-focused chirped laser pulse in plasma has been studied with the exponential plasma density ramp profile in the presence of a planar magnetostatic wiggler. It is evident that the exponential plasma density ramp is helpful in enhancing second-harmonic generation as, with the introduction of the exponential plasma density ramp, self-focusing becomes stronger and hence, it leads to enhance the harmonic generation of the second order in the plasma. Also, it is observed that the efficiency of second-harmonic generation enhances significantly with an increase in the value of the chirp parameter. Further, the magnetostatic wiggler helps in enhancing the harmonic generation of the second order. This is due to the fact that dynamics of the oscillating electrons is altered due to the Lorentz force which, in turn, modifies the plasma wave and, hence, results in the efficient second-harmonic generation.
Pseudoaneurysm of the aortic arch early after coarctation repair in the neonatal period
Authors: Sousa Ana R. , Teixeira Ana M. , Neves José P. 
Published: December 2019

AbstractAortic arch aneurysm or pseudoaneurysm is a rare complication early after coarctation repair in the neonatal period. We report the case of a newborn with a ventricular septal defect and aortic coarctation with a hypoplastic aortic arch that developed a large aortic arch pseudoaneurysm following a radically extended end-to-end coarctation repair. Successful surgical correction of the pseudoaneurysm was performed.
The geographies of justice in Portugal: redefining the judiciary's territories
Authors: Branco Patrícia 
Published: December 2019

AbstractIn this paper, I examine the current geographical location of Portuguese courts and the effects this territorial redefinition has had on the relationships between the justice system and the territories/populations in a context in which external and internal political factors, rather than a mere need to improve the justice system, have played a major role. Such an analysis entails three key elements: the geographic impacts on access to justice, in view of the emblematic presence of the state in the territories, both contrasted with the conflict between specialisation and the proximity of jurisdiction.
Belastungserleben von Müttern mit Kindern mit ADHS
Authors: Schwörer Mona Céline , Nitkowski Dennis , Petermann† Franz , Petermann Ulrike 
Published: December 2019

Zusammenfassung. Eltern von Kindern mit ADHS berichten von einer hohen psychischen Belastung, die durch die eigene und die kindliche Symptomatik bedingt scheint. Ziel der Studie ist es erstens zu prüfen, ob sich die mütterliche Belastung in Abhängigkeit davon unterscheidet, welche ADHS-Erscheinungsform bei den Kindern vorliegt und ob eine komorbide Symptomatik einer Störung mit oppositionellem Trotzverhalten (SOT) besteht. Zum zweiten soll untersucht werden, welche kindlichen und welche elterlichen Faktoren am besten die Gesamtbelastungen der Mütter aufklären können. An der Studie nahmen 207 Kinder ( M = 9.00 Jahre; SD = 1.52; 65.2 % männlich) teil. Von diesen wurden 138 Kinder nach dem ADHS-Erscheinungsbild (DSM-5) und nach der SOT in vier Untergruppen eingeteilt (unaufmerksames und gemischtes Erscheinungsbild mit/ohne SOT). Bei 157 Kindern wurden die mütterlichen (ADHS, Depression und Erziehungsstatus) und kindlichen Faktoren (ADHS, SOT und die Anzahl der im Haushalt lebenden Kinder) erhoben. Die Ergebnisse belegen, dass Mütter von Kindern, die neben einer ADHS eine zusätzliche SOT aufweisen, die größte Belastung berichten. Die mütterliche Depression und die gemischte ADHS-Erscheinungsform mit komorbider SOT des Kindes sagten die Belastung der Mütter am besten vorher. Im klinischen Kontext sollte bei Müttern von Kindern, die ein gemischtes ADHS-Erscheinungsbild mit SOT aufweisen, gezielt eine depressive Symptomatik abgeklärt werden.
Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer
Authors: Hunter Francis W. , Barker Hilary R. , Lipert Barbara , Rothé Françoise , Gebhart Géraldine , Piccart-Gebhart Martine J. , Sotiriou Christos , Jamieson Stephen M. F. 
Published: December 2019

AbstractThe HER2-targeted antibody–drug conjugate trastuzumab emtansine (T-DM1) is approved for the treatment of metastatic, HER2-positive breast cancer after prior trastuzumab and taxane therapy, and has also demonstrated efficacy in the adjuvant setting in incomplete responders to neoadjuvant therapy. Despite its objective activity, intrinsic and acquired resistance to T-DM1 remains a major clinical challenge. T-DM1 mediates its activity in a number of ways, encompassing HER2 signalling blockade, Fc-mediated immune response and payload-mediated microtubule poisoning. Resistance mechanisms relating to each of these features have been demonstrated, and we outline the findings of these studies in this review. In our overview of the substantial literature on T-DM1 activity and resistance, we conclude that the T-DM1 resistance mechanisms most strongly supported by the experimental data relate to dysfunctional intracellular metabolism of the construct and subversion of DM1-mediated cell killing. Loss of dependence on signalling initiated by HER2–HER2 homodimers is not substantiated as a resistance mechanism by clinical or experimental studies, and the impact of EGFR expression and tumour immunological status requires further investigation. These findings are instructive with respect to strategies that might overcome T-DM1 resistance, including the use of second-generation anti-HER2 antibody–drug conjugates that deploy alternative linker-payload chemistries.
Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p
Authors: Li Xiaoping , Yang Bo , Ren Haixia , Xiao Ting , Zhang Liang , Li Lei , Li Mingjiang , Wang Xuhui , Zhou Honggang , Zhang Weidong 
Published: December 2019

AbstractIn this study, we identified a novel circRNA, circ_0002483, and further investigated its functions in the progression and Taxol resistance of NSCLC. We found that circ_0002483 was expressed at low levels in NSCLC tissues and cell lines. Functional assays indicated that circ_0002483 overexpression significantly inhibited NSCLC cell proliferation and invasion in vitro and in vivo and enhanced the sensitivity of NSCLC cells to Taxol. Mechanistically, circ_0002483 was identified to sponge multiple miRNAs including miR-182-5p (also named miR-182), miR-520q-3p, miR-582-3p, miR-587, and miR-655. In addition, circ_0002483 was also demonstrated to regulate the expression of GRB2, FOXO1, and FOXO3, three target genes of miR-182-5p, by sponging miR-182-5p. Circ_0002483 was demonstrated to inhibit NSCLC progression in vitro and in vivo and enhanced the sensitivity of NSCLC cells to Taxol by sponging miR-182-5p to release the inhibition on GRB2, FOXO1, and FOXO3 mRNAs.