bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refining sleep measurement using the Motionwatch8©: how many days of monitoring do we need to get reliable estimates of sleep quality for older adults with mild cognitive impairment?
Authors: Falck Ryan S. , Barha Cindy K. , Chan Patrick C. Y. , Liu-Ambrose Teresa 
Published: June 2020

Abstract
Background
Poor sleep is common among older adults with mild cognitive impairment (MCI)—a transition stage between healthy cognition and dementia. Objective, reliable, and low-burden field methods to measure older adult sleep are also currently needed. The MotionWatch8© (MW8) wrist-worn actigraph provides estimates of sleep with 14 days of observation; however, there may be underlying differences in the reliability of sleep estimates based on MCI status. We therefore investigated the number of MW8 monitoring days required to estimate sleep in older adults with MCI and without.

Methods
Older adults (55+ years; N = 151) wore the MW8 for ≥14 days. The Montreal Cognitive Assessment was used to categorize participants with probable MCI (scores of < 26/30) and participants without MCI (≥ 26/30). We calculated intra-class reliability coefficients for one, seven, and 14 days of wear-time, and performed Spearman-Brown predictions to determine the number of monitoring days needed for an ICC = 0.80.

Results
Older adults with MCI were older (p < 0.01), more likely to be male (p = 0.03), and had shorter sleep duration (p < 0.01). Spearman-Brown analyses indicated that the number of monitoring days needed for an ICC = 0.80 in older adults with probable MCI was 7 days for sleep duration, 4 days for fragmentation, and 4 days for efficiency; adults without MCI required 4 days for duration, 6 days for fragmentation, and 3 days for efficiency.

Conclusions
Our results indicate that while the reliability of MW8 estimates of sleep differs based on cognitive status, 7 days of MW8 monitoring provides reliable estimates of sleep for adults with MCI and those without.
Evaluation of two viral isolates as a potential biocontrol agent against the Egyptian cotton leafworm, Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae)
Authors: Elmenofy Wael , Salem Reda , Osman Engy , Yasser Norhan , Abdelmawgod Alaa , Saleh Maryam , Zaki Aya , Hanafy Engy , Tamim Sally , Amin Salma , El-Bakry Aml , El-Sayed Aya , El-Gaied Lamiaa 
Published: June 2020

AbstractTwo different Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) nucleopolyhedrovirus (SpliNPV) isolates were obtained from natural infected S. littoralis larvae in Egypt. The phylogenetic analysis of the partial nucleotide sequence of the polyhedrin gene (polh) showed that both isolates, Spli-6 and Spli-7, were closed and had a common ancestor with S. littoralis NPV isolate 1263 polyhedrin gene, partial coding sequence with accession number AGE90003.1 that belongs to group II NPVs. This indicates that the natural host of Spli-6 and Spli-7 must be S. littoralis. The virulence of these isolates was tested against S. littoralis larvae in a laboratory. The LC50 against 1st instar larvae was significantly different, 3 × 104 OBs/ml and 9.5 × 104 OBs/ml for Spli-6 and Spli-7, respectively. However, the LC50 for the mixed infection of both isolates was 3.9 × 104 OBs/ml. On the other hand, the ST50 was 96 h for both isolates, while it was 120 h for the mixed infection, which was higher than that observed of each single isolate. Upon digestion of viral DNA with ScaI endonuclease, the restriction profile showed one more fragment of about ~ 25 kbp and 3 fragments of about ~ 19, ~ 5.8, and ~ 5.3 kbp in Spli-7 isolate compared to Spli-6 as well as the reference strain SpliNPV-AN1956. The differences in the fragment size and number suggest the existence of genotypic variants between both isolates. Spli-6 and Spli-7 proved to possess promising insecticidal properties for the development of virus-based biopesticide for the control of S. littoralis.
BRCA Mutations, Homologous DNA Repair Deficiency, Tumor Mutational Burden, and Response to Immune Checkpoint Inhibition in Recurrent Ovarian Cancer
Authors: Liu Ying L. , Selenica Pier , Zhou Qin , Iasonos Alexia , Callahan Margaret , Feit Noah Z. , Boland Julia , Vazquez-Garcia Ignacio , Mandelker Diana , Zehir Ahmet , Burger Robert A. , Powell Daniel J. , Friedman Claire , Cadoo Karen , Grisham Rachel , Konner Jason A. , O’Cearbhaill Roisin E. , Aghajanian Carol , Reis-Filho Jorge S. , Weigelt Britta , Zamarin Dmitriy 
Published: June 2020

PURPOSE Homologous DNA repair–deficient (HRD) ovarian cancers (OCs), including those with BRCA1/2 mutations, have higher levels of genetic instability, potentially resulting in higher immunogenicity, and have been suggested to respond better to immune checkpoint inhibitors (ICIs) than homologous DNA repair–proficient OCs. However, clinical evidence is lacking. The study aimed to evaluate the associations between BRCA1/2 mutations, HRD, and other genomic parameters and response to ICIs and survival in OC. METHODS This is a single-institution retrospective analysis of women with recurrent OC treated with ICIs. BRCA1/2 mutation status and clinicopathologic variables were abstracted from the medical records. Targeted and whole-exome sequencing data available for a subset of patients were used to assess tumor mutational burden (TMB), HRD, and fraction of genome altered (FGA). ICI response was defined as lack of disease progression for ≥ 24 weeks. Associations of BRCA1/2 status and genomic alterations with progression-free survival (PFS) and overall survival (OS) were determined using Cox proportional hazards models. RESULTS Of the 143 women treated with ICIs, 134 had known BRCA1/2 mutation status. Deleterious germline or somatic BRCA1/2 mutations were present in 31 women (24%). There was no association between presence of BRCA1/2 mutations and response ( P = .796) or survival. Genomic analysis in 73 women found no association between TMB ( P = .344) or HRD ( P = .222) and response, PFS, or OS. There were also no significant differences in somatic genetic alterations between responders and nonresponders. High FGA was associated with an improvement in PFS ( P = .014) and OS ( P = .01). CONCLUSION TMB, BRCA1/2 mutations, and HRD are not associated with response or survival, cautioning against their use as selection criteria for ICI in recurrent OC. FGA should be investigated further as a biomarker of response to immunotherapy in OC.
The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis
Authors: Sun Yi , Hong Liang , Gao Changbai 
Published: June 2020

Objective: To evaluate the correlation among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis.
Methods: In this cross-sectional study, the RA patients treated in our hospital were analyzed between January 2015 and November 2019. Bone mineral density was measured using dual energy X-ray absorptiometry, and at the beginning of the study, serum samples were collected and the level of 14-3-3η, TNF-α, and IL-6 was tested using the quantitative enzyme-linked immunosorbent assay, and I-CTX and PINP were measured using automatic electrochemical luminescence immune-analyzer for all the participants.
Results: In the current study, 285 patients with rheumatoid arthritis were enrolled and assigned into normal, osteopenia, and osteoporotic group respectively. The level of 14-3-3η and IL-6 presented with the highest value in the osteoporosis group, but the lowest value in the normal group, and there were significant differences in the level of 14-3-3η and IL-6 among the groups (p<0.05), and there was positive correlation between 14-3-3η and IL-6 (p<0.05). There were significant differences in PINP and I-CTX among the three groups (p<0.05), and a significantly positive correlation between I-CTX and 14-3-3η (p<0.05) and a significantly negative correlation between PINP and 14-3-3η (p<0.05) were found.
Conclusion: There was a significant correlation among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis, the influence of 14-3-3η on osteoporosis may be contributed to its adjusting inflammation and bone remodeling.
doi: https://doi.org/-10.12669/pjms.36.5.2403
How to cite this:Sun Y, Hong L, Gao C. The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis. Pak J Med Sci. 2020;36(5):872-876. doi: https://doi.org/10.12669/pjms.36.5.2403
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Discurso e Empreendedorismo Social: O que a Prática de Estudantes Engajados em Projetos Sociais pode Revelar?
Authors: Mineiro Andrea Aparecida da Costa , Dornela Fernanda Junia , Arantes Isabel Cristina da Silva , Cougo Juliano Silva 
Published: June 2020

Objetivo do estudo: Este estudo objetiva compreender, sob a ótica da Análise Crítica do Discurso (ACD), as concepções discursivas dos estudantes sobre a experiência prática de projetos sociais na disciplina de Empreendedorismo Social (ES) do curso de Administração da UNIFEI-MG. Metodologia/abordagem: Assim como sugere Norman Fairclough (2001; 2003), considerou-se o discurso como uma prática social e, foram analisadas as práticas textuais, discursivas e sociais dos estudantes investigados. Os discursos foram coletados por meio da realização de dois grupos focais e os resultados analisados com base na ACD.Principais resultados: Os resultados apontam que há divergências nas produções discursivas de ambos os grupos de estudantes, sendo que o grupo com alto aproveitamento acadêmico revela um discurso pautado na racionalidade substantiva, com emoção, intensidade e se baseia em valores direcionados a um bem coletivo. Em contraste, o grupo que obteve baixo aproveitamento acadêmico se pauta na racionalidade instrumental, e na necessidade de se trabalhar por um retorno financeiro.Contribuições teóricas/metodológicas: Evidenciou-se que as concepções discursivas externalizadas refletem a prática discursiva do ES, mas ao mesmo tempo demarcam o discurso gerencial hegemônico da Administração e sua lógica instrumental.Relevância/originalidade: Kedmenec et al. (2016) e Shahverdi et al. (2018) reforçam a relevância da incorporação do conteúdo discursivo de ES nos cursos tradicionais. Constata-se que o ES é capaz de proporcionar soluções efetivas para diversos problemas sociais, econômicos e ambientais, na perspectiva de valorização do caráter humanitário e da emancipação social (Shahverdi et al., 2018).
Sequenciamento da produção: uma proposta para o sistema make to order
Authors: Ribeiro Vanessa , Cordeiro Nelly H. Marques 
Published: June 2020

Um dos objetivos do sequenciamento da produção é a movimentação sincronizada de insumos dentro de um processo produtivo de maneira rápida e ordenada nos recursos disponíveis, visando o processamento de pedidos para atender a demanda do mercado. Diante disso, a presente pesquisa pretende apresentar uma proposta de sequenciamento dos subprodutos que compõe o produto produzido por uma indústria de equipamentos médicos, ao passo que seu sistema de manufatura é classificado como job shop com capacidade finita em um ambiente make to order. A proposta será desenvolvida por meio da análise e caracterização dos processos produtivos; levantamento das restrições; identificação das prioridades da organização, realização da cronoanálise dos subprodutos; e apresentação dos resultados obtidos por uma regra de sequenciamento utilizando o método gráfico de Gantt. Em relação aos procedimentos metodológicos de pesquisa, a abordagem utilizada foi a combinada de triangulação, quanto à sua finalidade é caracterizada como pesquisa aplicada, em relação aos seus objetivos é considerada descritiva, segundo os procedimentos utilizados é classificada como bibliográfica e pesquisa-ação. O resultado obtido foi o sequenciamento dos subprodutos por meio da regra menor tempo de processamento (MTP). As limitações da pesquisa estão relacionadas a escassez de um histórico de informações sobre os resultados da empresa.
Unharmonious early bilingualism in inter-ethnic Lithuanian emigrant familie
Authors: Hilbig Inga 
Published: June 2020

The article seeks to investigate the main reasons that cause inharmonious early bilingualism in inter-ethnic Lithuanian emigrant families. The data consist of extracts from 25 semi-structured interviews with Lithuanian women and Facebook comments of such emigrant mothers. Firstly, the study identifies the reasons why some informants themselves do not speak Lithuanian in their families, which leads to their children not even being able to understand it. These reasons can be lack of knowledge about the nature of early simultaneous bilingualism with a minority language, weak or negative attitudes towards Lithuanian and / or Lithuania, urgent need to fully integrate, influence of non-Lithuanian speaking partners, dominance of the majority language over bilingual mothers, and children’s passive bilingualism or insufficient comprehension skills. On their part, children can be growing up passively bilingual because of the minority language input shortage, not enough possibilities and real need to practice it in their daily lives, and because mothers tolerate bilingual conversations with certain discourse strategies. Finally, this paper examines the factors determining underdeveloped or attriting competences in the minority language. Children might be able to participate in very simple colloquial conversations in Lithuanian but cannot express themselves more freely in it or on different topics. They lack higher quality and more various input, e.g. through books or films in the Lithuanian language. They protest against minority language classes, where they could have a chance to learn to read and write in the minority language and further develop their skills. The analysis has revealed a variety of different reasons and their complex combinations that contribute to inharmonious bilingualism with Lithuanian as a minority language. They are objective and subjective, primary and secondary, sociolinguistic, psychological, pedagogical, and maybe some other reasons. A crucial role is played by mothers’ negative emotions in the face of struggles and children’s resistance, which also negatively affects success in bilingual child-rearing.
Is it reliable and valid if it is not replicable? On the importance of replicability in quantitative research
Authors: Vilkienė Loreta , Vilkaitė-Lozdienė Laura , Juknevičienė Rita , Bružaitė-Liseckienė Justina , Geben Kinga , Ryvitytė Birutė 
Published: June 2020

The idea of this paper arose in a reading group of several colleagues at the Faculty of Philology of Vilnius University after a discussion of a review article published by the editors of Language Teaching. Titled ‘Replication studies in language learning and teaching’ (2008), the paper focuses on replication studies and argues that they should be promoted and valued no less than original research. The participants of the reading group agreed that replication studies, understood here primarily as replications of quantitative research, are indeed an important issue that could be of interest to the broader community of applied linguists in Lithuania. The present paper argues that attempts to replicate earlier studies, which are very scarce or non-existent in Lithuania, deserve more attention both from novice and mature researchers. Replications are particularly valuable in developmental studies where replicating a study over a period of time allows the researcher to obtain data for continued analysis. Furthermore, a replication of a published study that deals with data collected in one country offers an opportunity to verify its findings in a different context and this way consolidates our understanding of phenomena under study. Finally, replication is an invaluable learning method to a novice linguist, be it a senior undergraduate or postgraduate student. Thus the authors of this paper would like to promote the idea of replication research in our community as well as encourage everyone interested make use of the increasingly growing amount of open access data available on the internet.
Prevalence of Diagnosed Obstructive Sleep Apnea in the United States 2013-2016: Insured Patients Actively Seeking Care
Authors: Suomi Joanna , Hess Gregory , Won Christine , Bron Morgan , Acquavella John 
Published: June 2020

Background: The prevalence of obstructive sleep apnea (OSA) has not been assessed within the United States (US) in over adecade.
Objectives:From 2013 to 2016, we calculated annual 2-year limited duration prevalence of diagnosed OSA in a large (~66million), geographically diverse insured population. We evaluated trends by age and sex; and assessed positive airway pressure (PAP) use and excessive sleepiness (hypersomnia diagnosis, or prescriptions for stimulant or wake-promoting agent [WPA]).
Methods:Overall and age/sex specific prevalence per 100 insured persons was calculated on an annual basis. The cohort was defined to include those with medical and pharmacy claims activity. To mitigate rule-out diagnoses,cases had to have ≥2 medical claims for OSA within a 6-month period. Overall annual prevalences were directly standardized to the US population using 2016 US age and sex Census weights.
Results: Annualage/sex adjusted prevalence of OSA increased from 2.4% in 2013 to 3.4% in 2016. OSA patients had a mean age of 58 years and there was a ≈2:1 male:female prevalence ratio. OSA patients with PAP claims increased from 42.2% to 44.1% over the study period. Excessive sleepiness (hypersomnia or stimulant/WPA prescriptions) for patients with or without PAP use both declined by ≈ 4% -5%.
Conclusions:Diagnosed OSA prevalence and PAP use among insured members with claims activity increased during 2013-2016 while clinical markers of excessive sleepiness declined. Males had a much higher prevalence of OSA than females.
KAJIAN EKONOMIS PEMELIHARAAN IKAN LELE (Clarias sp.) DENGAN METODE PEMELIHARAAN SISTEM BOSTER DAN SISTEM KONVENSIONAL
Authors: Kristiany Maria G.E. 
Published: June 2020

Kementerian Kelautan dan Perikanan (KKP) mentargetkan hasil produksi budidaya perikanan mencapai 22,46 juta ton pada tahun 2017 (Soebjakto, 2017) dengan ikan lele mencapai 1.217 ribu ton pada tahun 2016 dan 1.399 ribu ton pada tahun 2017 (DJPB, 2016). Tingkat efisiensi pakan merupakan modal terbesar dalam usaha pembesaran lele. Beberapa upaya-upaya yang telah dilakukan oleh pembudidaya ikan lele seperti yang dikembangkan dengan menerapkan sistem lele sehat boster yang memiliki hasil daging lele yang sehat dan bersih. Tujuan dari kajian ini adalah untuk mengetahui kegiatan budidaya ikan lele yang lebih effisien dan layak dari segi ekonomi antara pemeliharaan secara konvensional dengan sistem boster. Dari hasil pengukuran kualitas air seperti suhu, pH, DO, Nitrat dan nitrit selama pemeliharaan pada kedua perlakuan masih pada kisaran yang layak, demikian juga data SR, FCR dan ADG masih pada kisaran yang baik Dari analisa keuangan hasil didapat untuk pemeliharaan di sistem boster : BC ratio; 1.57, BEP; 4.758 dan PP; 0,64 sedangkan pemeliharaan sistem konvensional BC ratio; 1.09 BEP; 6.646 dan PP; 2.7. Dari hasil analisa tersebut dapat disimpulkan bahwa pemeliharan ikan lele dengan sistem boster lebih ekonomis dibandingkan dengan pemeliharaandengan sistem konvensional.
PARAMETER POPULASI DAN TINGKAT PEMANFAATAN IKAN KUNIRAN (Upeneus sulphureus, Cuvier 1829) DI PERAIRAN SELAT MALAKA
Authors: Nurulludin Nurulludin , Siswantining Titin , Taufik Muhammad , Purwoko Rudy Masuswo 
Published: June 2020

Sumberdaya ikan kuniran (Upeneus sulphureus) di Selat Malaka telah dieksploitasi sejak lama dengan alat tangkap pukat tarik, terutama sebelum adanya moratorium pelarangan alat tangkap trawl dan sejenisnya. Penelitian dilaksanakan pada bulan Januari - November 2014 di Perairan Selat Malaka. Pengukuran panjang cagak ikan kuniran diambil secara acak terhadap 2.694 sampel yang dilakukan di PPS Belawan. Tujuan penelitian ini adalah untuk menganalisis beberapa parameter pertumbuhan populasi ikan kuniran (Upeneus sulphureus) di Selat Malaka. Analisis data parameter populasi dianalisis menggunakan FAO-ICLARM Stock Assessement Tools (FISAT). Hasil analisis diperoleh beberapa parameter populasi ikan kuniran dengan koefisien pertumbuhan (K) sebesar 0,80 per tahun, (L∞) 21,0 cm, (M) 1,73 per tahun (F) 2,51 per tahun, dan E 0,59 per tahun. Penambahan baru individu ke dalam populasi berlangsung sepanjang tahun dan mencapai puncaknya terjadi pada akhir musim timur (Juni – Agustus) sampai musim peralihan II (September – Nopember). Pemanfaatan ikan kuniran di perairan Selat Malaka sebelum moratorium pelarangan pukat tarik dalam kondisi jenuh (Fully exploited).
Kinematics of Fault Slip Associated with the 4–6 July 2019 Ridgecrest, California, Earthquake Sequence
Authors: Pollitz Fred F. , Murray Jessica R. , Svarc Jerry L. , Wicks Charles , Roeloffs Evelyn , Minson Sarah E. , Scharer Katherine , Kendrick Katherine , Hudnut Kenneth W. , Nevitt Johanna , Brooks Benjamin A. , Mencin David 
Published: June 2020

ABSTRACT
The 2019 Ridgecrest, California, earthquake sequence produced observable crustal deformation over much of central and southern California, as well as surface rupture over several tens of kilometers. To obtain a detailed picture of the fault slip involved in the 4 July M 6.4 foreshock and 6 July M 7.1 mainshock, we combine strong-motion seismic waveforms with crustal deformation observations to obtain kinematic and static slip models of both events. We sample the regional seismic wavefield for both the foreshock and mainshock with three-component records from 31 stations of the California Integrated Seismic Network. The deformation observations include Global Positioning System (GPS), Interferometric Synthetic Aperture Radar (InSAR), and borehole strainmeter recordings of the dynamic strain field. These data collectively constrain the kinematic coseismic slip distributions of the events, with measurements variously observing coseismic slip from one event (e.g., seismic waveforms, kinematic solutions from continuous GPS, and strainmeter time series) or coseismic slip from both events combined (InSAR). We find that the foreshock ruptured two separate faults, one with left-lateral strike slip on a northeast–southwest-trending fault and the other with right-lateral strike slip on an orthogonal fault, with unilateral rupture propagation along both. The mainshock ruptured a series of northwest–southeast-trending faults with right-lateral strike slip concentrated in the uppermost 6 km with exceptionally low-rupture velocity averaging 1.0–1.5  km/s. A possible explanation for the low-rupture velocity is that the mainshock rupture expended relatively high energy, generating secondary fractures in off-fault deformation, which is consistent with field and seismic evidence of plastic deformation on small fault strands adjacent to the main rupture trace.