bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multilevel governance energy planning and policy: a view on local energy initiatives
Authors: Dobravec Viktorija , Matak Nikola , Sakulin Christian , Krajačić Goran 
Published: January 2021

AbstractBackgroundA sustainable energy system based on renewables, energy-efficiency, decentralisation of energy generation and synergies between different sectors requires new energy planning methods and policies. Energy transition and climate change mitigation achievement can no longer be seen only through top-down activities from a national government. Local and regional governments have a crucial role in delivering public policies relevant to such endeavour. Therefore, the implementation of multilevel governance (MLG) has become a priority for fostering local and regional development more inclusively. Paper analyses the existing energy planning governance in Austria throughout the MLG structure by focusing on the alignment between the local energy and climate initiatives and the national and EU goals. Also, the paper examined the effectiveness of the current MLG structures and outlined the fields where improvements are needed. The successfulness of the MLG approach is shown on Judenburg city case study. Desk research is enhanced by a series of interviews with energy policy experts and implementation of case study measures in TIMES model.ResultsThe MLG analysis showed the solid alignment of different governance levels. In contrast, the comparison of the energy and climate initiatives on the local level outlined recommendations for the design of more effective energy planning approach. Four areas of action are identified for further improvement: territorial fragmentation, data availability, spatial energy planning and new integrated MLG. The remaining non-conventional biomass potential of the Murtal region is enough to increase the share of district heating for the residential buildings of the Judenburg city from 16.3 to 30.8% while the building refurbishment increases district heating share to 32%.ConclusionApplication of MLG analysis demonstrated the alignment of energy targets in Austrian policy on different governance levels. The general willingness of Austrian municipalities to take part in local energy actions was shown through the local initiatives’ analysis. It is argued that strengthening the listed areas of work is necessary to raise the effectiveness of the local initiatives. The case study for the city of Judenburg developed in the TIMES model confirmed that coordinated actions from different levels of governance lead to effective implementation of measures.
An open trial of app-assisted acceptance and commitment therapy (iACT) for eating disorders in type 1 diabetes
Authors: Merwin Rhonda M. , Moskovich Ashley A. , Babyak Michael , Feinglos Mark , Honeycutt Lisa K. , Mooney Jan , Freeman Sara P. , Batchelder Heather , Sangvai Devdutta 
Published: January 2021

AbstractBackgroundEating disorders (EDs) among individuals with type 1 diabetes (T1D) increase the risk of early and severe diabetes-related medical complications and premature death. Conventional eating disorder (ED) treatments have been largely ineffective for T1D patients, indicating the need to tailor treatments to this patient population and the unique conditions under which ED symptoms emerge (in the context of a chronic illness with unrelenting demands to control blood glucose, diet and exercise). The current study was a pilot open trial ofiACT, a novel intervention for EDs in T1D grounded in Acceptance and Commitment Therapy (ACT).iACT was based on the premise that ED symptoms emerge as individuals attempt to cope with T1D and related emotional distress.iACT taught acceptance and mindfulness as an alternative to maladaptive avoidance and control, and leveraged personal values to increase willingness to engage in T1D management, even when it was upsetting (e.g., after overeating). A tailored mobile application (“app”) was used in between sessions to facilitate the application of ACT skills in the moment that individuals are making decisions about their diabetes management.MethodsAdults with T1D who met criteria for an ED completed 12 sessions ofiACT (with three optional tapering sessions). In addition to examining whether treatment was acceptable and feasible (the primary aim of the study), the study also examined whetheriACT was associated with increased psychological flexibility (i.e., the ability to have distressing thoughts/feelings about diabetes while pursuing personally meaningful values), and improvements in ED symptoms, diabetes management and diabetes distress.ResultsTreatment was acceptable to T1D patients with EDs and feasible to implement. Participants reported increased psychological flexibility with diabetes-related thoughts/feelings, and less obstruction and greater progress in pursuing personal values. There were large effects for change in ED symptoms, diabetes self-management and diabetes distress from baseline to end-of-treatment (Cohen’sd = .90–1.79). Hemoglobin A1calso improved, but thep-value did not reach statistical significance,p = .08.ConclusionsFindings provide preliminary evidence foriACT to improve outcomes for T1D patients with EDs and support further evaluation of this approach in a controlled trial.Trial registrationNCT02980627. Registered 8 July 2016.
Family members’ reflections upon a family-based inpatient treatment program for adolescent anorexia nervosa: a thematic analysis
Authors: Nilsen Jan-Vegard , Rø Øyvind , Halvorsen Inger , Oddli Hanne Weie , Hage Trine Wiig 
Published: January 2021

Abstract
Background
Family-based outpatient treatment is usually recommended as the treatment of choice when a child develops anorexia nervosa. However, some young persons will inevitably require higher levels of care. Qualitative research on family perspectives may help inform strategies to adapt family-based practices into intensified treatment settings. Our overarching aim was to investigate family members’ perspectives following a family-based inpatient treatment program for adolescent anorexia nervosa and to discuss clinical implications for treatment providers.

Methods
A subsample of eight families taking part in a naturalistic outcome study at a specialized eating disorder unit participated in the study (8 patients, 14 parents, and 10 siblings). The thematic analyses were inductive, predominantly descriptive, and guided by a multi-perspective framework.

Results
Five main themes were identified: 1: Expectations and evaluation of needs. Entering treatment from different vantage points, 2: Interactions with peers during the admission as highly beneficial or problematic, 3: Perspectives on staff expertise and the eating disorder unit’s structure, 4: Influencing within family relationships in different ways, and 5: Being admitted is at best only half the job: reflections on leaving the eating disorder unit.

Conclusions
Our study offers insight into how former inpatients and their family members experienced an inpatient treatment program designed to align treatment with the central elements of an outpatient family-based treatment approach for adolescent anorexia nervosa. Overall, the findings support emerging research underlining the necessity of strengthening the family-based treatment approach within intensified treatment settings. Moreover, the results emphasized the need for more knowledge on how to optimize inpatient treatment as well as the importance of providing smooth transitions between care settings.
Prevalence and associated factors of internet addiction among undergraduate university students in Ethiopia: a community university-based cross-sectional study
Authors: Zenebe Yosef , Kunno Kunuya , Mekonnen Meseret , Bewuket Ajebush , Birkie Mengesha , Necho Mogesie , Seid Muhammed , Tsegaw Million , Akele Baye 
Published: January 2021

AbstractBackgroundInternet addiction is a common problem in university students and negatively affects cognitive functioning, leads to poor academic performance and engagement in hazardous activities, and may lead to anxiety and stress. Behavioral addictions operate on a modified principle of the classic addiction model. The problem is not well investigated in Ethiopia. So the present study aimed to assess the prevalence of internet addiction and associated factors among university students in Ethiopia.ObjectivesMain objective of this study was to assess the prevalence and associated factors of internet addiction among University Students in Ethiopia.MethodsA community-based cross-sectional study was conducted among Wollo University students from April 10 to May 10, 2019. A total of 603 students were participated in the study using a structured questionnaire. A multistage cluster sampling technique was used to recruit study participants. A binary logistic regression method was used to explore associated factors for internet addiction and variables with apvalue < 0.25 in the bivariate analysis were fitted to the multi-variable logistic regression analysis. The strength of association between internet addiction and associated factors was assessed with odds ratio, 95% CI andpvalue < 0.05 in the final model was considered significant.ResultsThe prevalence of internet addiction (IA) among the current internet users was 85% (n = 466). Spending more time on the internet (adjusted odds ratio (AOR) = 10.13, 95% CI 1.33–77.00)), having mental distress (AOR = 2.69, 95% CI 1.02–7.06), playing online games (AOR = 2.40, 95% CI 1.38–4.18), current khat chewing (AOR = 3.34, 95% CI 1.14–9.83) and current alcohol use (AOR = 2.32, 95% CI 1.09–4.92) were associated with internet addiction.ConclusionsThe current study documents a high prevalence of internet addiction among Wollo University students. Factors associated with internet addiction were spending more time, having mental distress, playing online games, current khat chewing, and current alcohol use. As internet addiction becomes an evident public health problem, carrying out public awareness campaigns may be a fruitful strategy to decrease its prevalence and effect. Besides to this, a collaborative work among stakeholders is important to develop other trendy, adaptive, and sustainable countermeasures.
Concurrent chemoradiation in locally advanced primary middle ear lymphoepithelial carcinoma: An effective treatment modality case report
Authors: Fong Pei Yuan , Tan Tiong Yong , Kiong Kimberley Liqin 
Published: January 2021

Background Definitive treatment of primary middle ear lymphoepithelial carcinoma (LEC) is not well established owing to the rarity of this disease entity. We report a case of locally advanced primary middle ear LEC treated with concurrent chemoradiation, with good oncologic outcomes. Case presentation A 46 year-old female of Cantonese (Southern Chinese) descent presented with a four-month history of left sided hearing loss and non-pulsatile tinnitus, associated with progressive ipsilateral facial weakness. She had a left facial palsy (House-Brackmann 2) which then deteriorated to complete palsy over 2 weeks. Otoscopic examination of the left ear revealed a red-hued mass replacing the tympanic membrane. There was no cervical lymphadenopathy. Fibreoptic nasoendoscopy was unremarkable. Pure tone audiometry revealed profound mixed left hearing loss with type B impedance. Computed tomography of the temporal bone showed an ill-defined left middle ear mass with erosion of the malleus, tegmen tympani and facial canal. Magnetic Resonance Imaging showed an avidly enhancing lesion involving the dura of the left middle cranial fossa, tympanic and labyrinthine portions of the facial nerve. This mass extended into the apex of the left internal acoustic canal and basal turn of the cochlea. Histopathology confirmed EBV-positive primary middle ear LEC. Concurrent chemoradiation comprising 70Gy of intensity-modulated radiation therapy and 3 cycles of concurrent Cisplatin based chemotherapy over a 6 week period was administered. The patient achieved near-complete disease resolution on 3 month post-treatment imaging. Serum EBV DNA titres declined to undetectable levels and the patient is disease-free at 18 months post-diagnosis. Discussion and conclusion Concurrent chemoradiation with curative intent may be a viable treatment option for locally advanced middle ear LEC not amenable to surgical resection due to expected surgical morbidity. It confers good oncologic outcomes that mimic the response in other head and neck EBV-related lymphoepithelial carcinomas.
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
Authors: Vandenabeele Marjan , Veys Lien , Lemmens Sophie , Hadoux Xavier , Gelders Géraldine , Masin Luca , Serneels Lutgarde , Theunis Jan , Saito Takashi , Saido Takaomi C. , Jayapala Murali , De Boever Patrick , De Strooper Bart , Stalmans Ingeborg , van Wijngaarden Peter , Moons Lieve , De Groef Lies 
Published: January 2021

AbstractIn this study, we report the results of a comprehensive phenotyping of the retina of theAppNL-G-Fmouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in theAppNL-G-Fmouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that theAppNL-G-Fretina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.
Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain
Authors:   the Cognitive Function and Ageing Study, Bury Joanna J. , Chambers Annabelle , Heath Paul R. , Ince Paul G. , Shaw Pamela J. , Matthews Fiona E. , Brayne Carol , Simpson Julie E. , Wharton Stephen B. 
Published: January 2021

AbstractType 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes in cortical neurones, and associated astrocytes and endothelial cells of the neurovascular unit, in the ageing brain. Neurone, astrocyte, and endothelial cell-enriched mRNA, obtained by immuno-laser capture microdissection of temporal cortex (Brodmann area 21/22) from 6 cases with self-reported T2D in the Cognitive Function and Ageing Study neuropathology cohort, and an equal number of age and sex-matched controls, was assessed by microarray analysis. Integrated Molecular Pathway Level Analysis was performed using the Kyoto Encyclopaedia of Genes and Genomes database on significantly differentially expressed genes, defined as P < 0.05 and fold-change ± 1.2. Hub genes identified from Weighted Gene Co-expression Network Analysis were validated in neurones using the NanoString nCounter platform. The expression and cellular localisation of proteins encoded by selected candidate genes were confirmed by immunohistochemistry. 912, 2202, and 1227 genes were significantly differentially expressed between cases with self-reported T2D and controls in neurones, astrocytes, and endothelial cells respectively. Changes in cortical neurones included alterations in insulin and other signalling pathways, cell cycle, cellular senescence, inflammatory mediators, and components of the mitochondrial respiratory electron transport chain. Impaired insulin signalling was shared by neurovascular unit cells with, additionally, apoptotic pathway changes in astrocytes and dysregulation of advanced glycation end-product signalling in endothelial cells. Transcriptomic analysis identified changes in key cellular pathways associated with T2D that may contribute to neuronal damage and dysfunction. These effects on brain cells potentially contribute to a diabetic dementia, and may provide novel approaches for therapeutic intervention.
Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits
Authors: Ho Wan Yun , Agrawal Ira , Tyan Sheue-Houy , Sanford Emma , Chang Wei-Tang , Lim Kenneth , Ong Jolynn , Tan Bernice Siu Yan , Moe Aung Aung Kywe , Yu Regina , Wong Peiyan , Tucker-Kellogg Greg , Koo Edward , Chuang Kai-Hsiang , Ling Shuo-Chien 
Published: January 2021

AbstractAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of the same disease spectrum of adult-onset neurodegenerative diseases that affect the motor and cognitive functions, respectively. Multiple common genetic loci such as fused in sarcoma (FUS) have been identified to play a role in ALS and FTD etiology. Current studies indicate that FUS mutations incur gain-of-toxic functions to drive ALS pathogenesis. However, how the disease-linked mutations of FUS affect cognition remains elusive. Using a mouse model expressing an ALS-linked human FUS mutation (R514G-FUS) that mimics endogenous expression patterns, we found that FUS proteins showed an age-dependent accumulation of FUS proteins despite the downregulation of mouse FUS mRNA by the R514G-FUS protein during aging. Furthermore, these mice developed cognitive deficits accompanied by a reduction in spine density and long-term potentiation (LTP) within the hippocampus. At the physiological expression level, mutant FUS is distributed in the nucleus and cytosol without apparent FUS aggregates or nuclear envelope defects. Unbiased transcriptomic analysis revealed a deregulation of genes that cluster in pathways involved in nonsense-mediated decay, protein homeostasis, and mitochondrial functions. Furthermore, the use of in vivo functional imaging demonstrated widespread reduction in cortical volumes but enhanced functional connectivity between hippocampus, basal ganglia and neocortex in R514G-FUS mice. Hence, our findings suggest that disease-linked mutation in FUS may lead to changes in proteostasis and mitochondrial dysfunction that in turn affect brain structure and connectivity resulting in cognitive deficits.
New missions of a hospital pharmaceutical technology unit during the COVID-19 pandemic
Authors: Garnier Alexandra , Falaschi Ludivine , Bonnabry Pascal , Bouchoud Lucie 
Published: January 2021

AbstractThe pharmaceutical technology unit of the Geneva University Hospitals played a significant role in the fight against COVID-19 through four different missions: (1) providing enough hydroalcoholic solution at the peak of the pandemic; (2) facing supply chain management issues; (3) adapting the workload to the crisis and, above all, (4) managing the human resources necessary to handle these activities.
A review: preprocessing techniques and data augmentation for sentiment analysis
Authors: Duong Huu-Thanh , Nguyen-Thi Tram-Anh 
Published: January 2021

AbstractIn literature, the machine learning-based studies of sentiment analysis are usually supervised learning which must have pre-labeled datasets to be large enough in certain domains. Obviously, this task is tedious, expensive and time-consuming to build, and hard to handle unseen data. This paper has approached semi-supervised learning for Vietnamese sentiment analysis which has limited datasets. We have summarized many preprocessing techniques which were performed to clean and normalize data, negation handling, intensification handling to improve the performances. Moreover, data augmentation techniques, which generate new data from the original data to enrich training data without user intervention, have also been presented. In experiments, we have performed various aspects and obtained competitive results which may motivate the next propositions.
Thinning effects on biomass and element concentrations of roots in adjacent hornbeam and oak stands in Istanbul, Turkey
Authors: Akburak Serdar , Makineci Ender 
Published: January 2021

Abstract
Background
Thinning is a commonly used treatment in forest management which affects the tree root systems. The effects of thinning on element concentrations and seasonal change of roots were evaluated in adjacent oak (Quercus frainetto Ten.) and hornbeam (Carpinus betulus L.) stands according to the different root diameter classes.

Method
Two replicated control and thinning plots (50 m × 50 m) were set for each species (hornbeam and oak). Thinning treatments (November 2010) reduced 50% of the basal area in both oak and hornbeam stands. Roots were assessed by seasonal collection over 2 years (from October 2010 to October 2012). The roots were then sorted into diameter classes of 0–2 mm (fine roots), 2–5 mm (small roots) and > 5 mm (coarse roots). C, N, P, K, Ca, Na, Mg, S, Mn, Fe, Al, Zn, Pb, Ni, Cu and Cd were analyzed.

Results
Except coarse roots, the highest root biomasses were determined in April-2011 in all plots. Fine-root biomass in oak was found significantly higher in control plots. In contrast to the oak, the fine-root biomass in the thinned hornbeam plots was higher than in the controls. The small-root biomass did not significantly differ between the thinned and the control plots in both oak and hornbeam stands. However, the coarse-root biomass showed significant differences between the control (1989 g∙m− 2) and thinned plots (1060 g∙m− 2) in oak, while no difference was detected in hornbeam. The concentrations of C, Al, Pb, Cd, Ni, Zn, Mn, Na, K, Mg and P in the fine roots of oak were significantly higher in the thinned plots. However, the concentration of Pb, Cd and Fe in the fine roots was significantly higher in the thinned plots of hornbeam. Significant differences were observed between the species for all elements in the fine roots except for C, N and P. In particular, elements in the fine roots tended to increase in July in the oak. In the hornbeam, all element concentrations in the fine roots (except C, N, and S) in the thinned plots showed a tendency to increase in April. The concentrations of Pb, Ni, Al, Fe, Cu, Ca, Na, K, Mg and P in the hornbeam control plots increased during the April 2011 period.

Conclusion
The results indicated that thinning effects on temporal changes and concentrations of elements in the roots could be attributed to species-specific characteristics.
Cerebellar ataxia and exercise intolerance in Erdheim-Chester disease
Authors: Lauricella Eleonora , d’Amati Antonio , Ingravallo Giuseppe , Foresio Maurizio , Ribatti Domenico , de Tommaso Marina , Cives Mauro , Girolamo Francesco 
Published: January 2021

Abstract
Background
Erdheim-Chester disease (ECD), a rare disorder of monocyte/macrophage lineage, has been related to cerebellar dysfunction. To increase the awareness of this rare, protean disease, an unusual, myasthenia-like onset of ECD is reported.

Case presentation
A 42-year-old man presented with a 6-year history of mild evening fatigability in his four limbs followed by motor and cognitive symptoms associated with cerebellar atrophy, dentate nuclei and dentato-thalamic pathway degeneration. Magnetic resonance imaging revealed hyperintense signals in T2 and fluid-attenuated inversion recovery sequences within the pons, cerebellar white matter, dentate nuclei and globi pallidi in the absence of any contrast enhancement. Whole-body bone scintigraphy with 99Technetium - methylene diphosphonate and fluorodeoxyglucose-positron emission tomography both revealed symmetric uptake in the lower extremities a finding suggestive of a diagnosis of ECD. Histological examination revealed diffuse infiltration of CD 68+ histiocytes with foamy cytoplasms in the presence of B-type of Rapidly Accelerated Fibrosarcoma protein kinase (BRAF)V600E activating mutation in tumor cells.

Conclusion
In patients with myasthenia-like symptoms who test negatively for myasthenia gravis, neurodegenerative diseases, and disorders of the hypothalamus, a diagnosis of ECD should be taken into consideration.