bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems with Bazett QTc Correction in Paediatric Screening of Prolonged QTc Interval
Authors: Andršová Irena , Hnatkova Katerina , Helánová Kateřina , Šišáková Martina , Novotný Tomáš , Kala Petr , Malik Marek 
Published: October 2020

Abstract
BackgroundBazett formula is frequently used in paediatric screening for the long QT syndrome (LQTS) and proposals exist that using standing rather than supine electrocardiograms (ECG) improves the sensitivity of LQTS diagnosis. Nevertheless, compared to adults, children have higher heart rates (especially during postural provocations) and Bazett correction is also known to lead to artificially prolonged QTc values at increased heart rates. This study assessed the incidence of erroneously increased QTc values in normal children without QT abnormalities.MethodsContinuous 12-lead ECGs were recorded in 332 healthy children (166 girls) aged 10.7±2.6 years while they performed postural manoeuvring consisting of episodes (in the following order) of supine, sitting, standing, supine, standing, sitting, and supine positions, each lasting 10 minutes. Detailed analyses of QT/RR profiles confirmed the absence of prolonged individually corrected QTc interval in each child. Heart rate and QT intervals were measured in 10-second ECG segments and in each segment, QTc intervals were obtained using Bazett, Fridericia, and Framingham formulas. In each child, the heart rates and QTc values obtained during supine, sitting and standing positions were averaged. QTc durations by the three formulas were classified to <440 ms, 440-460 ms, 460-480 ms, and >480 ms. ResultsAt supine position, averaged heart rate was 77.5±10.5 beat per minute (bpm) and Bazett, Fridericia and Framingham QTc intervals were 425.3±15.8, 407.8±13.9, and 408.2±13.1 ms, respectively. At sitting and standing, averaged heart rate increased to 90.9±10.1 and 100.9±10.5 bpm, respectively. While Fridericia and Framingham formulas showed only minimal QTc changes, Bazett correction led to QTc increases to 435±15.1 and 444.9±15.9 ms at sitting and standing, respectively. At sitting, Bazett correction identified 51, 4, and 0 children as having the QTc intervals 440-460, 460-480, and >480 ms, respectively. At sitting, these numbers increased to 118, 11, and 1, while on standing these numbers were 151, 45, and 5, respectively. Irrespective of the postural position, Fridericia and Framingham formulas identified only a small number (<7) of children with QT interval between 440 and 460 ms and no children with longer QTc.ConclusionDuring screening for LQTS in children, the use of Bazett formula leads to a high number of false positive cases especially if the heart rates are increased (e.g. by postural manoeuvring). The use of Fridericia formula can be recommended to replace the Bazett correction not only for adult but also for paediatric ECGs.
Reducing False Triggering Caused by Irrelevant Mental Activities in Brain-Computer Interface Based on Motor Imagery
Authors: Zhou Lujia , Tao Xuewen , He Feng , Zhou Peng , Qi Hongzhi 
Published: October 2020

Abstract
Background: In recent years, the brain-computer interface (BCI) based on motor imagery (MI) has been considered as a potential post-stroke rehabilitation technology. However, the recognition of MI relies on the event-related desynchronization (ERD) feature, which has poor task specificity. Further, there is the problem of false triggering (irrelevant mental activities recognized as the MI of the target limb). Methods: In this paper, we discuss the feasibility of reducing the false triggering rate using a novel paradigm, in which the steady-state somatosensory evoked potential (SSSEP) is combined with the MI (MI-SSSEP). Data from the target (right hand MI) and nontarget task (rest) were used to establish the recognition model, and three kinds of interference tasks were used to test the false triggering performance. In the MI-SSSEP paradigm, ERD and SSSEP features modulated by MI could be used for recognition, while in the MI paradigm, only ERD features could be used. Results: The results showed that the false triggering rate of interference tasks with SSSEP features was reduced to 29.3%, which was far lower than the 55.5% seen under the MI paradigm with ERD features. Moreover, in the MI-SSSEP paradigm, the recognition rate of the target and nontarget task was also significantly improved. Further analysis showed that the specificity of SSSEP was significantly higher than that of ERD (p<0.05), but the sensitivity was not significantly different. Conclusions: These results indicated that SSSEP modulated by MI could more specifically decode the target task MI, and thereby may have potential in achieving more accurate rehabilitation training.
Effects of a Robot-aided Somatosensory Training on Proprioception and Motor Function in Stroke Survivors
Authors: Yeh I-Ling , Holst-Wolf Jessica , Elangovan Naveen , Cuppone Anna Vera , Lakshminarayan Kamakshi , Capello Leonardo , Masia Lorenzo , Konczak Jürgen 
Published: October 2020

Abstract
Background- Proprioceptive deficits after stroke are associated with poor upper limb function, slower motor recovery, and decreased self-care ability. Improving proprioception should enhance motor control in stroke survivors, but current evidence is inconclusive. Thus, this study examined whether a robot-aided somatosensory-based training requiring increasingly accurate active wrist movements improves proprioceptive acuity and motor performance in chronic stroke. Methods - Twelve adults with chronic stroke completed a 2-day training (age range: 42 – 74 years; median time-after-stroke: 12 months; median Fugl-Meyer UE: 65). Retention was assessed at Day 5. Grasping the handle of a wrist-robotic exoskeleton, participants trained to roll a virtual ball to a target through continuous wrist adduction/abduction movements. During training vision was occluded, but participants received real-time, vibro-tactile feedback on their forearm about ball position and speed. Primary outcome was the just-noticeable-difference (JND) wrist position sense threshold as a measure of proprioceptive acuity. Secondary outcomes were spatial error in an untrained wrist tracing task and somatosensory-evoked potentials (SEP) as a neural correlate of proprioceptive function. Ten neurologically-intact adults were recruited to serve as non-stroke controls for age, gender and hand dominance (age range: 44 to 79 years; 6 women, 4 men).Results – Participants significantly reduced JND thresholds at posttest and retention (F(2, 38) = 4.54, p = 0.017, ηp2 = 0.20) in both groups. A higher pretest JND threshold was associated with a higher threshold reduction at posttest and retention (r = -0.86, -0.90, p ≤ 0.001) among the stroke participants. Error in the untrained tracing task was reduced by 22% at posttest, yielding an effect size of w = 0.13. Stroke participants exhibited significantly reduced P27-N30 peak-to-peak SEP amplitude at pretest (U = 11, p = 0.03) compared to the non-stroke group. SEP measures did not change systematically with training.Conclusion - This study provides proof-of-concept that non-visual, proprioceptive training can induce fast, measurable improvements in proprioceptive function in chronic stroke survivors. There is encouraging but inconclusive evidence that such somatosensory learning transfers to untrained motor tasks.Trial Registration Clinicaltrials.gov; Registration ID: NCT02565407; Date of registration: 01/10/2015; URL: https://clinicaltrials.gov/ct2/show/NCT02565407
Insights Into the First Seven-months of COVID-19 Pandemic in Bangladesh: Lessons Learned from a High-risk Country
Authors: Siam Md. Hasanul Banna , Hasan Md.Mahbub , Tashrif Shazed Mohammad , Khan Md. Hasinur Rahaman , Raheem Enayetur , Hossain Mohammad Sorowar 
Published: October 2020

Abstract
BackgroundSouth Asian countries including Bangladesh have been struggling to control the COVID-19 pandemic despite imposing months of lockdown and other public health measures. In-depth epidemiological information from these countries is lacking. From the perspective of Bangladesh, this study aims at understanding the epidemiological features and gaps in public health preparedness and risk communication. MethodsThe study used publicly available data of seven months (8 March 2020–10 September 2020) from the respective health departments of Bangladesh and Johns Hopkins University Coronavirus Resource Centre. Human mobility data were obtained from Google COVID-19 Community Mobility Reports. Spatial distribution maps were created using ArcGIS Desktop. Descriptive statistics was used to report the incidence, case fatality rates (CFR), and trend analysis. Results Despite nationwide lockdown, an increase in human mobility linked to specific public events was observed. During this period, a total of 47,153 cases and 650 deaths were reported. As lockdown ended, the incidence rate was increased by around 50% within a week. In seven months, about 350,000 cases were identified with a CFR of 1.4%. Males were disproportionately affected in terms of infection (71%) and death (77%) than females. The CFR for males was higher than females (1.4% versus 1.11%). Over 50% of infected cases were reported among young adults (20-40-year age group). Trends of the cumulative incidence were slower in South Asia with lower mortality compared to the EU and USA. As of 10 September 2020, over 20,000 frontline health workers were affected, and more than 2100 unofficial deaths were reported. Reduced testing capacity was observed as compared to other countries. Although a downward trend in laboratory test positive percentage was seen, the number of new deaths per day remained largely unchanged. ConclusionWe identified critical gaps in public health preparedness and risk communication in battling COVID-19 pandemic. We believe our findings, observations and recommendations will function as a valuable resource to facilitate better public health decisions for managing current and future infectious disease like COVID-19 in the settings of developing countries.
Metal-free atom transfer radical polymerization: reaching ppm catalyst loading under sunlight
Authors: Ma Qiang , Song Jinshuai , Zhang Xun , Jiang Yu , Ji Li , Liao Saihu 
Published: October 2020

Abstract
Organocatalytic atom transfer radical polymerization (O-ATRP) is recently emerging as an appealing method for the synthesis of metal-free polymer materials with well-defined microstructures and architectures. However, the development of highly effective catalysts that can be employed at a practical low loading are still a challenging task. Herein, we introduce a catalyst design logic based on heteroatom-doping of polycyclic arenes, which led to the discovery of oxygen-doped antratherene (ODA) as a new class of organic photoredox catalysts for O-ATRP. In comparison with known organocatalysts, ODAs feature strong visible-light absorption together with high molar extinction coefficient (ε455nm up to 23950 M–1cm–1), which allow for the establishment of a controlled polymerization under sunlight at low ppm levels of catalyst loading.
Seven Things to Know About The Homicides of Doctors. A Review of 30 Years From Italy.
Authors: Lorettu Liliana , Nivoli Alessandra MA , Daga Irma , Milia Paolo , Depalmas Cristiano , Nivoli Giancarlo , Bellizzi Saverio 
Published: October 2020

Abstract
Background. Healthcare workers have a 16 times greater risk of suffering workplace violence than workers in other sectors and around 50% experience workplace violence in the course of their career. The objective of this study is to explore the characteristics and circumstances of work-related killings of doctors. Methods. Work-related homicides of doctors over the period 1988-2019 were identified retrospectively through the Italian national statistical agencies. Variables such as perpetrator, motive and location of the crime were obtained through forensic psychiatric work. After classification, the absolute and percent values of the main characteristics of the homicides were calculated. Results. Over the period considered, 21 doctors were killed in Italy in connection with their professional activity. In 52% (n=11) of cases, the killer was one of the doctor’s patients, in 29% (n=6) of cases it was a patient’s relative, in 19% (n=4) an occasional patient (first consultation). The location of the homicide was a community clinic in 48% (n=10) of cases, the street in 19% (n=4) of cases, the doctor’s home in 14% (n=3), the hospital in 14% (n=3) and the patient’s home in 5% (n=1). In 57% (n=12) of cases the perpetrator was not affected by any mental disorders. The motive for the homicide was revenge without previous threats in 52.4% (n=11) of cases; in 28.6% (n=6) the revenge was preceded by stalking. Conclusions. Doctors should be aware that the risk of being killed is not limited to hospital settings and that their patients’ family members might also pose a threat to them.
Health Seeking Behavior and Associated Factors among Individuals with Cough in Yiwu, China: A Population-based Study
Authors: sun xiaoyan , Luo Shuying , Lou Lingqiao , Cheng Hang , Ye Zhen , Jia Jianwei , Wei Yina , Tao Jingbo , He Hanqing 
Published: October 2020

Abstract
Background: Previous studies have shown that a certain proportion of the population did not seek medical treatment after coughing, and understanding the potential reasons is crucial for disease prevention and control. Method: A population-based study was conducted with the probability proportional to population size sampling in Yiwu, Zhejiang, China. A total of 5,855 individuals aged ≥ 15 years lived in Yiwu, China for more than 6 months were included. All participants completed a pad-based questionnaire to collect detailed information by a face-to-face interview. Characteristics of individuals were described by categories of health seeking behavior using frequency and percentage. Univariate and multivariate logistic regression analyses were performed to estimate the associations of social-demographic and cough characteristics with health seeking behavior. Results: 19.3% (1,129/5,855) of participants had a cough in the past month, 40% (452/1,129) had sought medical treatment. Of these, 26.5% (120/452) chose hospitals at county level or above. Individuals aged ≥65 years old (OR=2.25, 95%CI: 1.23, 4.12), female (OR=1.57, 95%CI: 1.21, 2.06), living in rural areas (OR=1.30, 95%CI: 1.003, 1.69), persistent cough for 3-8 weeks (OR=2.91, 95%CI: 1.72, 4.92) and with more accompanying symptoms (P trend<0.001) were more likely to seek medical treatment, but those coughed for >8 weeks were not (p>0.5). Female (OR=0.33, 95%CI: 0.21, 0.54) and people living in rural areas (OR=0.57, 95%CI: 0.36, 0.92) were less likely to choose hospitals at county level or above while the higher educated were more likely to (OR=3.29, 95% CI: 1.35, 8.02). Those who coughed for more than 2 weeks were more likely to choose hospitals at or above the county level. But the number of accompanying symptoms does not show any significant relationship with the choice of medical facility.Conclusion: The present study found that age, gender, living areas and features of cough were associated with health seeking behavior. It is worth noting that coughing too long(e.g. >8 weeks) instead of seeking medical treatment. Targeted measures should be developed based on the key factors found in this study to guide persons to seek medical treatment more scientifically.
Cardiac Resynchronization Therapy and its Effects in Patients with type 2 DIAbetes Mellitus OPTimized in Automatic vs. Echo Guided Approach. Data from the DIA-OPTA Investigators
Authors: Sardu Celestino , Paolisso Pasquale , Ducceschi Valentino , Santamaria Matteo , Sacra Cosimo , Massetti Massimo , Ruocco Antonio , Marfella Raffaele 
Published: October 2020

Abstract
Objectives: To evaluate the effects of cardiac resynchronization therapy (CRTd) in patients with type 2 diabetes mellitus (T2DM) optimized via automatic vs. echocardiographic guided approach. Background: Suboptimal optimization of atrio-ventricular (AV) and inter-ventricular (VV) timings reduces CRTd response. Thus, we hypothesize that automatic CRTd optimization could ameliorate clinical outcomes in T2DM patients.Methods: We designed a prospective, multicenter study to recruit, from October 2016 to June 2019, 191 patients with T2DM and heart failure (HF) candidate to receive a CRTd. Study outcomes were CRTd responders rate, hospitalizations for HF worsening, cardiac deaths and all cause of deaths in T2DM patients treated with a CRTd and randomly optimized via automatic (n 93) vs. echocardiographic (n 98) guided approach at 12 months of follow-up.Results: We had a significant difference in CRTd responders rate (68 (73.1%) vs. 58 (59.2%), p 0.038), and hospitalization for HF worsening (12 (16.1%) vs. 22 (22.4%), p 0.030) in automatic vs. echo-guided group of patients. At multivariate Cox regression analysis, automatic guided approach (3.636 [1.271-10.399], CI 95%, p 0.016) and baseline highest values of atrium pressure (automatic SonR values, 2.863 [1.537-6.231], CI 95%, p 0.006) predicted CRTd responders rate. In automatic group, we had significant difference in SonR values comparing CRTd responders vs. non responders (1.24 ± 0.72 g vs. 0.58 ± 0.46 g (follow-up), p 0.001), hospital admission for HF worsening events (0.48 ± 0.29 g vs. 1.18 ± 0.43 g, p 0.001), and cardiac deaths ( 1.13 ± 0.72 g vs. 0.65 ± 0.69 g, p 0.047).Conclusions: automatic optimization increased CRTd responders rate, and reduced hospitalizations for HF worsening. Intriguingly, automatic CRTd and highest baseline values of SonR could predict the outcome of CRTd responders. Notably, there is a significant difference in SonR values for CRTd responders vs. non responders, hospitalizations for HF worsening and cardiac deaths. Clinical trial: ClinicalTrials.gov Identifier NCT04547244;
The Cost‑utility of Early use of High-flow Nasal Cannula in Bronchiolitis
Authors: Buendia Jefferson Antonio , Acuña-Cordero Ranniery , Rodriguez-Martinez Carlos E. 
Published: October 2020

Abstract
Background: High-flow nasal cannula (HFNC) oxygen is a non-invasive ventilation system that was introduced as an alternative to CPAP (continuous positive airway pressure), with a marked increase in its use in pediatric care settings .This study aimed to evaluate the cost-effectiveness of early use of HFNC compared to oxygen by nasal cannula in an infant with bronchiolitis in the emergency setting. Methods: A decision tree model was used to estimate the cost-effectiveness of HFNC compared with oxygen by nasal cannula (control strategy) in an infant with bronchiolitis in the emergency setting. Cost data were obtained from a retrospective study on bronchiolitis from tertiary centers in Rionegro, Colombia, while utilities were collected from the literature. Results:The QALYs per patient calculated in the base-case model were 0.9141 (95% CI 0.913- 0.915) in the HFNC and 0.9105 (95% CI 0.910- 0.911) in control group. The cost per patient was US$368 (95% CI US$ 323- 411) in HFNC and US$441 (95% CI US$ 384-498) per patient in the control group.Conclusions: HFNC in emergency settings was cost-effective for the hospital treatment of an infant with bronchiolitis
A Rare Pulmonary Myoepithelial Tumor With Novel TRPS1-PLAG1&nbsp;Fusions
Authors: ZHENG Qiang , LI Shenglei , BAI Qianming , ZHOU Xiaoyan , WANG Yue , Li Yuan 
Published: October 2020

Abstract
Background: Little is known about the morphological and molecular features of intra-thoracic myoepithelial tumors. Here, we describe a rare pulmonary myoepithelial tumor with novel TRPS1-PLAG1 fusions.Case presentation: A 30-year-old male presented with multiple lung nodules that detected by routine computed tomography (CT) scan 3 years ago. Positron emission tomography-computed tomography (PET-CT) demonstrated a well-circumscribed mass with a diameter of 3cm in the left pulmonary hilum and multiple nodules in bilateral lungs. No other extra-thoracic primary lesion and distant metastasis was found. The clinical history was not other specified. Microscopically, these lesions were well-defined, showed nodular growth pattern filling the bronchioles and alveoli. The tumor cells were epithelioid to plasmacytoid with slightly eosinophilic cytoplasm, arranged in aggregates, nests and cords. Myxoid background presented in some foci. Nuclear pleomorphism was mild and mitotic activity was not prominent. No distinct gland formation was identified. Immunostains demonstrated that the tumor cells were diffusely positive for pan-cytokeratin (AE1/AE3), CK5/6, S100, SOX10, and negative for calponin. Noticeably, a TRPS1-PLAG1 gene fusion was identified in this tumor by targeted RNA sequencing involved TRPS1 exon1 and PLAG1 exon2, this rare rearrangement was validated by fluorescence in situ hybridization (FISH) for PLAG1 break-apart probe, and 30% tumor cells showed break apart signals. Conclusions: Here we present the first case of a disseminated thoracic myoepithelial tumor with novel TRPS1-PLAG1 fusions. Targeted RNA sequencing strongly facilitates precise classification and providing opportunities for unknown fusion partner discovery, which is significant for risk stratification and development of potential therapeutic targets.
Protocol for a systematic review on classification, outcomes and follow-up of patients undergoing reconstructive surgery after Noma disease-
Authors: Speiser Sophie , Langridge Benjamin , Birkl Moira Melina , Kubiena Harald , Rodgers Will 
Published: October 2020

Abstract
Background: NOMA is a significant yet neglected disease which affects children in some of the least developed countries in the world. Surgical reconstructive missions for patients affected by NOMA are undertaken regularly by surgeons from more developed countries. However, the long-term benefit and safety of these missions have recently been criticized due to a perceived lack of measurable outcomes and appropriate follow-up. We are conducting a systematic review to critically evaluate the classification systems, outcome measurement tools, and follow-up periods reported in the literature for NOMA disease. Methods: This systematic review is undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (“PRISMA”) guidelines. The databases MEDLINE, Embase and Web of Science are searched from infinity to 24th of April 2019. All original publications of studies undertaken on reconstructive surgery for NOMA disease, reporting data on outcome after surgery, follow-up time and complications are eligible for inclusion. The primary outcome of interest are the outcome measurement methods used for assessing successful reconstructive surgery after NOMA disease. Other outcomes we are assessing are methods for classification of disease severity and time to last follow-up. The quality of evidence for each summary outcome measure is assessed using the MINORS criteria. Discussion: Given the precarious situations in the countries where mission surgeons often undertake reconstructive surgery, time pressure and the lack of infrastructure on site prevent them from being able to measure the effect of their surgical outcomes. Our goal is to express the key points of debate and make recommendations for how future surgical missions can be improved. We aim to do so by comparing the current best standards of practice Publishing this protocol will help future NOMA surgeons plan their missions in a standardised and reproducible way, striving towards a future of worldwide high-quality research.Systematic review registrations: This protocol was submitted to PROSPERO on the 02.10.2020 and is currently under assessment. (ID 181931)