bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Secondhand Smoke Exposure Among Nonsmoking Pregnant Women: A Systematic Review
Authors: Nwosu Chidiogo , Angus Kathryn , Cheeseman Hazel , Semple Sean 
Published: May 2020

Abstract

Introduction
Exposure to secondhand smoke (SHS) in pregnancy leads to an increased risk of stillbirths, congenital malformations, and low birth weight. There is a lack of evidence about how best to achieve reductions in SHS exposure among nonsmoking pregnant women. This work systematically reviews individual or household interventions to reduce pregnant women’s exposure to SHS.

Methods
MEDLINE, EMBASE, and CINAHL databases were searched from their dates of inception to April 17, 2019. Studies were included if: participants were nonsmoking pregnant women; involved an intervention to reduce SHS exposure or encourage partner quitting; and measured SHS exposure of pregnant women and/or recorded quit rates among partners. The UK National Institute for Health & Care Excellence (NICE) Quality Appraisal checklist was used to determine internal and external validity.

Results
Nine studies met the inclusion criteria. Educational interventions were primarily targeted at the pregnant woman to change her or others’ behavior, with only two studies involving the partner who smoked. Intervention delivery was mixed, spanning brief discussions through to more involving sessions with role play. The effective interventions involved multiple follow-ups. There was no standardized method of assessing exposure to SHS. Many of the included studies had moderate to high risk of bias.

Conclusion
There is mixed evidence for interventions aimed at reducing pregnant women’s exposure to SHS, though multi-component interventions seem to be more effective. The effectiveness of family-centered approaches involving creating smoke-free homes alongside partner smoking cessation, perhaps involving pharmacological support and/or financial incentives, should be explored.

Implications
• Measures to protect nonsmoking pregnant women from SHS tend to place the responsibility for “avoidance” on the woman.
• There is little work that seeks to involve the smoking partner or other smokers in protecting pregnant women from SHS.
• Interventions to create smoke-free homes and/or smoking partner cessation need to be developed: pharmacological and financial support should be explored.
Valence of Media Coverage About Electronic Cigarettes and Other Tobacco Products From 2014 to 2017: Evidence From Automated Content Analysis
Authors: Kim Kwanho , Gibson Laura A , Williams Sharon , Kim Yoonsang , Binns Steven , Emery Sherry L , Hornik Robert C 
Published: May 2020

Abstract

Introduction
As media exposure can influence people’s opinions and perceptions about vaping and smoking, analyzing the valence of media content about tobacco products (ie, overall attitude toward tobacco, cigars, electronic cigarettes, etc.) is an important issue. This study advances the field by analyzing a large amount of media content about multiple tobacco products across six different media sources.

Aims and Methods
From May 2014 to December 2017, we collected all English-language media items about tobacco products that U.S. young people might see from mass media and websites (long-form) and social media (Twitter and YouTube). We used supervised machine learning to develop validated algorithms to label the valence of these media items. Using the labeled results, we examined the impact of product type (e-cigarettes vs. other tobacco products), source (long-form vs. social media), and time (by month) on the valence of coverage.

Results
We obtained 152 886 long-form media texts (20% with more than a passing mention), nearly 86 million tweets, and 12 262 YouTube videos about tobacco products. Most long-form media content opposed, while most social media coverage supported, the use of e-cigarettes and other tobacco products. Over time, within-source valence proportions were stable, though in aggregate, the amount of media coverage against the use of tobacco products decreased.

Conclusions
This study describes the U.S. public communication environment about vaping and smoking for young people and offers a novel big data approach to analyzing media content. Results suggest that content has gradually become less negative toward the use of e-cigarettes and other tobacco products.

Implications
This study is the first to examine how the valence of media coverage differs for e-cigarettes versus other tobacco products, across several media sources, and over time using a large corpus of media items. Unlike prior studies, these data allow us to draw conclusions about relative support and opposition for these two categories of products in a variety of media coverage because the same coding scheme was used across products and media sources.
Compliance With FDA Nicotine Warning Statement Provisions in E-liquid Promotion Posts on Instagram
Authors: Laestadius Linnea I , Wahl Megan M , Vassey Julia , Cho Young Ik 
Published: May 2020

AbstractIntroductionEffective August 2018, the U.S. Food and Drug Administration (FDA) required that nicotine addiction warnings be placed on ads for nicotine containing e-liquids. As per FDA comments, this provision pertains to visual ads communicated via social media, raising questions about compliance within the large e-liquid promotion community on Instagram.Aims and MethodsThis study examines use of warnings on promotional Instagram posts before and after provisions took effect on August 10, 2018. Netlytic was used to gather a sample of 500 promotional #eliquid and #ejuice posts from: May 2017, October 2017, March 2018, August 2018, and September 2018. The 1500 prewarning and 1000 postwarning posts were coded using content analysis. Changes in products and marketing strategies were also considered. Post volume was tracked monthly between May 2017 and February 2020.ResultsIn the prewarning period, nicotine warning statements were absent on all posts. Following August 10, 2018, FDA compliant warnings were present on 13.6% of posts. Among US-based posts, 36.4% used the warnings, with warnings more common on posts made by e-liquid brands (52.3%) and posts promoting e-liquids with nicotine (40.0%). Promotional strategies and products did not significantly change. The share of posts made by US Instagram users decreased by 11%, although total post volume continued to grow.ConclusionsMany e-liquid promotion posts on Instagram remained noncompliant with nicotine warnings after FDA provisions took effect. The large volume of international users also limited the impact of FDA-mandated warnings on the social media environment.ImplicationsFurther guidance and enforcement are needed to ensure that US e-liquid marketers on visual social media platforms adhere to current provisions, particularly for individual social media users who are sponsored by industry. The inherently global span of social media also indicates the importance of a shared approach to marketing regulations. Further work is needed to assess enforcement strategies viable for the social media environment.
全谷物摄入对炎症影响的新进展
Authors: Sang Shengmin , Idehen Emmanuel , Zhao Yantao , Chu YiFang 
Published: May 2020

Abstract
尽管诸多研究显示全谷物(whole grain, WG)的摄入和某些疾病
风险降低之间相关联，但是其生物学机制尚未完全明确。越来越多的
研究证据表明，炎症可能是其中的一个重要中介。此外，还发现多种
影响WGs 调节炎症的作用机制，包括纤维、植物化学物质及肠道菌群
代谢物。这些物质中有些是直接发挥作用的，有些是通过肠道菌群将
生物活性物质转化为更有价值的代谢物来调节炎症信号通路发挥作用。
这篇综述介绍了WGs 对亚临床炎症标志物影响的新证据，重点强调
了膳食纤维、某些WGs 植物化学物质和肠道菌群在WGs 抗炎作用中
的作用。
Quantitative and Qualitative Analyses of Triacylglycerol Production in the Wild-Type Cyanobacterium Synechocystis sp. PCC 6803 and the Strain Expressing AtfA from Acinetobacter baylyi ADP1
Authors: Tanaka Motoki , Ishikawa Toshiki , Tamura So , Saito Yujiro , Kawai-Yamada Maki , Hihara Yukako 
Published: May 2020

AbstractAlthough cyanobacteria do not possess wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT), the bacterial enzyme for triacylglycerol (TAG) production, there have been several studies reporting the accumulation of TAG-like compounds in cyanobacteria. In this study, we aimed to evaluate TAG productivity of the ΔrecJ::atfA strain of Synechocystis sp. PCC 6803 generated by inserting atfA encoding WS/DGAT from Acinetobacter baylyi ADP1 into recJ (sll1354), together with the wild type (WT) and the gene-disrupted strain of slr2103 having homology with eukaryotic DGAT2 gene family (Δ2103). Thin-layer chromatography (TLC) of neutral lipids or isolation of the neutral lipid-enriched fraction followed by gas chromatography or liquid chromatography–tandem mass spectrometry was employed for analyses. The ΔrecJ::atfA strain accumulated 0.508 nmol ml−1OD730−1 of TAG after a week of incubation at 100 μmol photons m−2 s−1. The saturated fatty acids C16:0 and C18:0 accounted for about 50% and 20% of the TAG fatty acids, respectively, suggesting that de novo-synthesized fatty acids were preferentially incorporated into TAG molecules. When the neutral lipid profile of the lipid extracts was examined by TLC, a spot located in a slightly lower position compared with the TAG standard was detected in WT but not in the Δ2103 strain. TAG accumulation levels of both strains was only 0.01–0.03 nmol ml−1OD730−1, but the fatty acid composition was substantially different from that of the background. These results suggest that trace amounts of TAG can be produced in Synechocystis cells by enzymes other than Slr2103, and major constituents of the TAG-like spot are unknown lipid species produced by Slr2103.
Petrologic Reconstruction of the Tieshan Magma Plumbing System: Implications for the Genesis of Magmatic-Hydrothermal Ore Deposits within Originally Water-Poor Magmatic Systems
Authors: Zhou Jin-Sheng , Wang Qiang , Wyman Derek A , Zhao Zhen-Hua 
Published: May 2020

Abstract
Most genetic models for magmatic-hydrothermal ore deposits are based on the prerequisite that the parental magmas associated with mineralization are enriched in water (&gt; ∼4 wt %). However, it has been recognized that a number of magmatic-hydrothermal ore deposits also formed within tectono-magmatic settings that produce initially water-poor magmas such as Climax-type porphyry deposits. Here, we present a detailed reconstruction of the Tieshan magma plumbing system related to skarn-porphyry Cu–Fe–Au mineralization in the Edong district, in which primitive magmas typically show water-poor features. Applications of multiple thermodynamic calibrations on various magmatic units from the Tieshan and Tonglushan deposits provide a wealth of information regarding the structure and evolution of the transcrustal magmatic system. Petrographic observations and clinopyroxene-liquid thermobarometry calculations indicate that the Tieshan magmatic-hydrothermal system was fed by a deep crustal magma reservoir. An accurate picture of the evolution of H2O within the magma plumbing system is presented using the plagioclase-liquid hygrometer in combination with the amphibole hygrometer. Three critical stages during the evolution of water within the plumbing system have been recognized, associated with H2O contents of 0·8–1·7 wt %, 2·1–2·8 wt % and 3·2–4·6 wt %, respectively. The first enrichment of water in the magmas can be attributed to the separation and transfer of evolved melts from the deep magma reservoir to the shallow crust. Continuous cooling and solidification of the shallow magma body gave rise to the second enrichment of H2O in residual melts, leading to magmas that were fertile for the formation of ore deposits. The detailed chemical evolution of the magma plumbing system was investigated using mineral trace element compositions in combination with the partition coefficients predicted by the lattice strain model. The earliest equilibrium melts are characterized by high Sr contents (the average = 658 ± 64 ppm), suggesting that high Sr/Y signatures were likely derived from their magma sources or fractionation at deeper levels in initially water-poor environments. Variations of some particular geochemical fingerprints in equilibrium melts such as, Dy/Dy* and Eu/Eu*, also provide fundamental information on the evolution of the magma plumbing system. Our study confirms the critical role of a deep crustal magma reservoir on the formation of magmatic-hydrothermal ore deposits. The fertility of magmas with respect to ore deposit formation was enhanced by the extraction and transfer of evolved magmas from the deep reservoir to shallower levels, particularly due to the enrichment of magmatic water contents. In addition, the presence of a deep magma reservoir also sustains the incremental growth of shallow magma chambers, which provide ore-forming fluids.
Your presence soothes me: a neural process model of aversive emotion regulation via social buffering
Authors: Mulej Bratec Satja , Bertram Teresa , Starke Georg , Brandl Felix , Xie Xiyao , Sorg Christian 
Published: May 2020

Abstract
The reduction of aversive emotions by a conspecific’s presence—called social buffering—is a universal phenomenon in the mammalian world and a powerful form of human social emotion regulation. Animal and human studies on neural pathways underlying social buffering typically examined physiological reactions or regional brain activations. However, direct links between emotional and social stimuli, distinct neural processes and behavioural outcomes are still missing. Using data of 27 female participants, the current study delineated a large-scale process model of social buffering’s neural underpinnings, connecting changes in neural activity to emotional behaviour by means of voxel-wise multilevel mediation analysis. Our results confirmed that three processes underlie human social buffering: (i) social support-related reduction of activity in the orbitofrontal cortex, ventromedial and dorsolateral prefrontal cortices, anterior and mid-cingulate; (ii) downregulation of aversive emotion-induced brain activity in the superficial cortex-like amygdala and mediodorsal thalamus; and (iii) downregulation of reported aversive feelings. Results of the current study provide evidence for a distinct neural process model of aversive emotion regulation in humans by social buffering.
Meta-analysis and Meta-regression of Cognitive Behavioral Therapy for Psychosis (CBTp) Across Time: The Effectiveness of CBTp has Improved for Delusions
Authors: Sitko Katarzyna , Bewick Bridgette M , Owens David , Masterson Ciara 
Published: May 2020

Abstract
Published research shows small-to-medium effects of Cognitive Behavioral Therapy for Psychosis (CBTp) on reducing psychotic symptoms. Given the on-going development of CBTp interventions, the aim of this systematic review is to examine whether the effectiveness of CBTp has changed across time. MEDLINE, EMBASE, PsycINFO, and CENTRAL were searched for randomized controlled trials examining CBTp interventions targeting positive and/or negative symptoms vs treatment as usual. Four meta-analyses were carried out to examine the effectiveness of CBTp for: positive symptoms; delusions; hallucinations; and negative symptoms. Four meta-regressions examined whether the effectiveness of CBTp changed across time for these groups of symptoms. A total of 28 studies (n = 2698) yielded a pooled g of −0.24 (95% confidence interval [CI] −0.32, −0.16, P &lt; .001) favoring CBTp for positive symptoms, with nonsignificant heterogeneity (Q = 26.87, P = .47; I2 =0%); 13 studies (n = 890) yielded a pooled g of −0.36 (95% CI −0.59, −0.13, P = .002) for delusions, with substantial heterogeneity (Q = 31.99, P = .001; I2 =62%); 16 studies (n = 849) yielded a pooled g of −0.26 (95% CI −0.42, −0.11, P &lt; .001) for hallucinations, with nonsignificant heterogeneity (Q = 18.10, P = .26; I2 =17%); 19 studies (n = 1761) yielded a pooled g of −0.22 (95% CI −0.33, −0.12, P &lt; .001) for negative symptoms, with nonsignificant heterogeneity (Q = 20.32, P = .32, I2 =11%). Meta-regressions indicated a significant effect of year on the effectiveness of CBTp only for delusions (F[1, 11] = 5.99, P = .032; R2 = 0.594); methodological quality did not effect this finding. Findings indicate small-to-medium effects of CBTp for psychotic symptoms, with increasing effectiveness across time for delusions.
Changes in dietary inflammatory potential predict changes in sleep quality metrics, but not sleep duration
Authors: Wirth Michael D , Jessup Angela , Turner-McGrievy Gabrielle , Shivappa Nitin , Hurley Thomas G , Hébert James R 
Published: May 2020

Abstract

Study Objectives
Non-pharmacological sleep interventions may improve sleep profiles without the side-effects observed with many pharmacological sleep aids. The objective of this research was to examine the association between sleep and inflammation and to examine how changes in dietary inflammatory potential influence changes in sleep.

Methods
The Inflammation Management Intervention Study (IMAGINE), which was a dietary intervention designed to lower inflammation, provided access to 24-h dietary recalls (24HR), objectively measured sleep using SensewearTM armbands, and a range of self-reported demographics, health histories, lifestyle behaviors, psychosocial metrics, anthropometric measurements, and inflammatory biomarkers. Dietary Inflammatory Index® (DII®) scores were calculated from three unannounced 24HR-derived estimated intakes of whole foods and micro and macronutrients over a 2-week period at baseline and post-intervention (i.e. month 3). Statistical analyses primarily utilized linear regression.

Results
At baseline, for every 1-min increase in sleep onset latency, tumor necrosis factor-α increased by 0.015 pg/mL (±0.008, p = 0.05). Every one-percentage increase in sleep efficiency was associated with decreased C-reactive protein (CRP) of −0.088 mg/L (±0.032, p = 0.01). Every 1-min increase in wake-after-sleep-onset (WASO) increased both CRP and interleukin-6. Compared to participants with pro-inflammatory DII changes over 3 months, those with anti-inflammatory changes decreased WASO (0 vs. −25 min, respectively, p &lt; 0.01) and improved sleep efficiency (−2.1% vs. +2.6%, respectively, p = 0.04).

Conclusions
Non-pharmacological treatments, such as anti-inflammatory diets, may improve sleep in some adults. Future research involving dietary treatments to improve sleep should not only focus on the general population, but also in those commonly experiencing co-morbid sleep complaints.

Clinical Trial Information
NCT02382458.
Hemiarthroplasty for Femoral Neck Fractures: Does Surgeon Subspecialty Affect Perioperative Outcomes?
Authors: Schumaier Adam P. , Andrews Erickson G. , Yue Ruixian A. , Lake Samuel S. , Evans Hardy T. , Scarberry Nathaniel W. , Kelley Todd C. , Archdeacon Michael T. , Le Theodore T. 
Published: May 2020

Objectives:
To determine if surgeon subspecialty training affects perioperative outcomes for displaced femoral neck fractures treated with hemiarthroplasty.

Design:
Retrospective comparative study.

Setting:
One health system with 2 hospitals (Level I and Level III trauma centers).

Patient and Participants:
Patients who were treated with hemiarthroplasty for displaced femoral neck fractures between October 2012 and September 2017.

Outcome Measures:
Leg length discrepancy, femoral offset, estimated blood loss (EBL), incidence of blood transfusion, time to surgery, operative time, and length of stay. Data were analyzed based on the treating surgeon's subspecialty training [arthroplasty (A), trauma (T), other (O)]. Hierarchical regression was used to compare the groups and control for confounding variables.

Results:
A total of 292 patients who received hemiarthroplasty for displaced femoral neck fractures were included (A = 158; T = 73; O = 61). Surgeon subspecialty had a statistically significant effect on operative time, with arthroplasty surgeons completing the procedure 9.6 minutes faster than trauma surgeons and 17.7 minutes faster than other surgeons (P < 0.01; ΔR2 = 0.03). Surgeon subspecialty did not significantly affect other outcomes, including leg length discrepancy (P = 0.26), femoral offset (P = 0.37), EBL (P = 0.10), incidence of transfusion (P = 0.67), time to surgery (P = 0.10), or length of stay (P = 0.67).

Conclusions:
This study demonstrates that arthroplasty-trained surgeons perform hemiarthroplasty slightly faster than other subspecialists, but subspecialty training does not affect other perioperative outcomes, including leg length discrepancy, femoral offset, EBL, transfusion rate, time to surgery, or length of stay. This suggests that hemiarthroplasty can be adequately performed by various subspecialists, and deferring treatment to an arthroplasty surgeon might not have a clinically significant benefit in the perioperative period.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Assessing Anticoagulation Management and Shared Decision-Making Documentation From Providers Participating in the SUPPORT-AF II Study
Authors: Hoque Laboni , Amroze Azraa , Gilvaz Vinit , Abraham Sonu , Lal Amos , Mishra Ajay , Crawford Sybil , Mazor Kathleen , McManus David D. , Kapoor Alok 
Published: May 2020

Background:
A previously tested intervention featured educational outreach with modified academic detailing (AD) to increase anticoagulation use in patients with atrial fibrillation. Currently, this study compares providers receiving and not receiving AD in terms of inclusion of AD educational topics and shared decision-making elements in documentation.

Methods:
Physicians reviewed themes discussed with providers during AD and evaluated charts for evidence of shared decision-making. Frequencies of documentation of individual items for providers receiving AD versus non-AD providers were compared. To understand baseline documentation practices of AD providers, encounters of AD providers before their AD participation were randomly selected.

Results:
There were 113 eligible encounters in the four months after AD—36 from AD providers and 77 from non-AD providers. Thirty-five encounters were identified from AD providers before participating in the intervention. Providers infrequently documented many reviewed items (% documenting): anticoagulation mentioned (44%), multiple options for anticoagulation (5%), CHA2DS2-VASc score (11%), bleeding risk factors (2%). Compared with non-AD providers, AD providers had statistically significant higher percentages for the following items: mention of anticoagulation (64% versus 35%), stroke risk (11% versus 0%), anticoagulation benefits (8% versus 0%), and patient involvement (17% versus 0%). There was no improvement, however, for AD providers compared with baseline documentation percentages.

Discussion:
Providers infrequently documented important items in anticoagulation management and shared decision-making. AD participation did not improve documentation. Improving adoption of AD educational items may require more prolonged interaction with providers. Improving shared decision-making may require an intervention more focused on it and its documentation.