bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined use of rotational and excimer lASER coronary atherectomy (RASER) during complex coronary angioplasty—An analysis of cases (2006–2016) from the British Cardiovascular Intervention Society database
Authors: Protty Majd B. , Gallagher Sean , Farooq Vasim , Sharp Andrew S.P. , Egred Mohaned , O'Kane Peter , Kinnaird Tim 
Published: November 2020

AbstractIntroductionCombining rotational (RA) and excimer laser coronary atherectomy (ELCA)—RASER atherectomy—is technique utilized in the percutaneous management of calcific coronary disease. The evidence base examining its safety and utility is sparse and limited to small case‐series. This study examines the patterns and outcomes of RASER atherectomy use in the largest cohort to date.MethodsUsing the British Cardiac Intervention Society database, data were analyzed on all PCI procedures in the UK between 2006 and 2016. Descriptive statistics and multivariate logistic regressions were used to examine baseline, procedural, and outcome associations with RASER.ResultsWe identified 153 (0.02%) RASER atherectomy cases out of 686,358 PCI procedures. Baseline covariates associated with RASER use were age, BMI, diabetes, stable coronary disease, and previous CABG. Procedural co‐variates associated with RASER were CTO‐PCI, the use of more/longer stents, intravascular imaging, cutting balloons, and microcatheters. Adjusted rates of in‐hospital major adverse cardiac/cerebrovascular events (MACCE) were not significantly different with RASER. However, there were higher odds of arterial complications (OR 3.23, 95% CI: 1.58–6.61), slow flow (OR 3.50, 95% CI: 1.29–9.55), and shock induction (OR 9.66, 95% CI: 3.44–27.06).ConclusionsRASER atherectomy use in complex PCI is associated with higher risk baseline and procedural characteristics. Although increased rates of shock induction, slow flow, and arterial complications were observed, RASER does not increase the likelihood of in‐hospital MACCE, major bleeding, or death.
Osseointegrated implant‐retained auricular prosthesis constructed using cone‐beam computed tomography and a prosthetically driven digital workflow: a case report
Authors: Domingue Daniel , Glenn Nathan Cory , Vest Allison , White James R. 
Published: November 2020

AbstractProsthetically driven workflows using CBCT, digital optical scanning, 3D‐printed molds and frameworks, and dental implant component attachments to osseointegrated fixtures can produce anatomically accurate, esthetic, durable silicone ear replacements.
High‐Capacity Iron‐Based Anodes for Aqueous Secondary Nickel−Iron Batteries: Recent Progress and Prospects
Authors: Yang Jiao , Chen Jingwei , Wang Zhixun , Wang Zhe , Zhang Qichong , He Bing , Zhang Ting , Gong Wenbin , Chen Mengxiao , Qi Miao , Coquet Philippe , Shum Ping , Wei Lei 
Published: November 2020

AbstractAqueous rechargeable nickel‐iron (Ni−Fe) batteries characterized by their ultra‐flat discharge plateau, low cost, and remarkable safety show attractive prospects for applications in wearable and large‐scale energy storage. Electrode materials, as the key part of Ni−Fe batteries, determine their performance. Comparatively, Fe‐based anode materials possess much lower capacity and energy density than available Ni‐based cathode materials; thus, the overall electrochemical performance of Ni−Fe batteries is dominated by Fe‐based anode materials. The key challenge of Fe‐based anodes for Ni−Fe batteries is their inferior electrochemical performance originating from their poor electrical conductivity. Recently, significant progress has been achieved in the development of Fe‐based anodes for Ni−Fe batteries through nanostructural design, componential regulation, interface engineering and elemental doping, whereby both intrinsic capacity and energy density have been enhanced. This Review presents an overview of the recent progress in Fe‐based anode materials by categories of metal, oxide, sulfide, hydroxide, phosphide and selenide based on chemical composition. Finally, the challenges and possible solutions are briefly presented with some perspectives toward the future development of Fe‐based anode materials for next‐generation aqueous secondary Ni−Fe batteries.
The Intrinsic Structural Resistance of a Grain Boundary to Transverse Ionic Conduction
Authors: Genreith‐Schriever Annalena R. , Parras Jana P. , Heelweg Henrik J. , De Souza Roger A. 
Published: November 2020

AbstractInvited for this month's cover picture is the group of Prof. Roger A. De Souza at RWTH Aachen University (Germany). The cover picture illustrates oxide ions moving from one crystal grain across a grain boundary to an adjacent grain in a polycrystalline oxide‐ion conductor. The mobile ions perceive the boundary as an additional resistance arising from the disruption of the crystal structure at the boundary. The resistance can be tuned by applying high electric fields. Read the full text of the Communication at 10.1002/celc.202000773.
Preparation of a Lanthanide–Titanium Oxo Cluster–Polymer Composite by CuI‐Catalyzed Click Chemistry
Authors: Deng Yong‐Kai , Zhao Ya‐Rui , Xu Han , Kong Xiang‐Jian , Long La‐sheng , Zheng Lan‐Sun 
Published: November 2020

AbstractIncorporating metal clusters within the skeleton of the organic polymers through a click reaction cannot only effectively prepare cluster–polymer composites, but also effectively avoid the cluster aggregation. Herein, an azide‐containing lanthanide–titanium oxo cluster of Eu8Ti10‐N3 (Eu8Ti10‐N3=[Eu8Ti10(μ3‐O)14(H2O)4(OAc)2(tbba)30(paza)4(THF)2]⋅4 THF⋅8 H2O (1), Htbba=4‐tert‐butylbenzoic acid, Hpaza=4‐azidobenzoate, HOAc=acetic acid, THF=tetrahydrofuran) through an in situ solvothermal reaction of 4‐azidobenzoic acid and 4‐tert‐butylbenzoic acid. Reaction of 1 with PEG (PEG=methoxypoly(ethyleneglycol)alkyne, 2000 g mol−1) through CuI‐catalyzed click chemistry generates a lanthanide–polymer composite of Eu8Ti10‐N3@PEG (2). Investigation with IR, 1H NMR and ICP‐OES of 2 indicates that the structural integrity of 1 is maintained in 2. Study of the luminescent properties of 1 and 2 reveals that the quantum yield of 1 itself basically remains unchanged in 2. Significantly, the formation of 2 cannot only effectively prevent the cluster 1 from aggregation, but also greatly enhance its solubility and adhesion to the substrate. Owing to the solubility and adhesion of luminescent materials being the key to their practical application, present work is thus of great significance for the development of metal cluster–polymer composite luminescent materials.
Thermodynamics of CO2 adsorption on cellulose‐derived biochar prepared in ionic liquid
Authors: Guo Tianxiang , Fan Zeng , Du Yarong , Xu Junpeng , Kong Lingfeng , Pan Yuanfeng , Xiao Huining , Xie Qing 
Published: November 2020

AbstractThis work focused on thermodynamic analysis of carbon dioxide (CO2) adsorption on a promising biochar as a CO2 adsorbent. The biochar was prepared by catalytic pyrolysis of cellulose material in ionic liquid at moderate temperature. The adsorption characteristics, such as adsorption capacity, interfacial potential, Gibbs free energy change, enthalpy change, entropy change, and internal energy change, influenced by adsorption temperature and gas pressure, were systematically investigated. The results indicated that CO2 adsorption on cellulose‐derived biochar was a spontaneous, physical, exothermic, and entropic decrement process, accompanied by adsorption capacity of 5.2 mmol/g and interfacial potential of −18.2 J/g at 273 K and 100 kPa. The process could be well described by adsorption potential theory. Then a quasi‐Gaussian distribution of site energy was verified for CO2 adsorption. The interfacial potential was found to be a monotropic function of the amount of CO2 adsorbed, and the latter was actually a differential of the former via adsorption potential. The positive temperature effect and negative pressure effect on negative Gibbs free energy change indicated that reducing adsorption temperature and increasing gas pressure were beneficial to CO2 uptake, accompanied by the increase of adsorption capacity and the reduction of interfacial energy, entropy, enthalpy, and internal energy. The strongest temperature effects on entropy change, enthalpy change, and internal energy change existed at given pressure or temperature. The pressure effect was stronger and more sensitive to pressure at lower adsorption pressure. More interestingly, the peak pressure or peak temperature with the strongest pressure effect possibly existed during CO2 adsorption.
Treatment of real industrial pharmaceutical wastewater using wet peroxide oxidation
Authors: Mylapilli Swami Venkat Prasad , Reddy Sivamohan N. 
Published: November 2020

AbstractThe presence of recalcitrant organic molecules with high amounts of chemical oxygen demand, low biodegradability, and lack of effective treatment for pharmaceutical wastewater result in environmental pollution. Batch wet peroxide oxidation (WPO) experiments have been performed to study the effect of temperature (150°C‐250°C), oxidant coefficient (OC 0‐3), and reaction time (20 minutes‐60 minutes) on degradation efficiency of industrial pharmaceutical wastewater. Box‐Behnken design (BBD) with response surface methodology was used to study the effect of independent parameters on total organic carbon (TOC) removal response. The optimum temperature, oxidant coefficient, and reaction time of the process were found to be 250°C, OC 3, and 60 minutes, which resulted in TOC conversion of 57.96%. The obtained quadratic model has been able to predict the response with minimum deviation. The experimental modelling results conveyed that influence of process parameters followed the order: temperature > time > oxidant coefficient. To improve the mineralization efficiency, process parameters were changed to attain the near complete conversion (~99%) of the pharmaceutical wastewater. The qualitative analysis also showed that only a few components of pharmaceuticals were present in the treated effluent.
Comparison of Density Functional and Correlated Wave Function Methods for the Prediction of Cu(II) Hyperfine Coupling Constants
Authors: Gómez‐Piñeiro Rogelio J. , Pantazis Dimitrios A. , Orio Maylis 
Published: November 2020

AbstractThe reliable prediction of Cu(II) hyperfine coupling constants remains a challenge for quantum chemistry. Until recently only density functional theory (DFT) could target this property for systems of realistic size. However, wave function based methods become increasingly applicable. In the present work, we define a large set of Cu(II) complexes with experimentally known hyperfine coupling constants and use it to investigate the performance of modern quantum chemical methods for the prediction of this challenging spectroscopic parameter. DFT methods are evaluated against orbital‐optimized second‐order Møller‐Plesset (OO‐MP2) theory and coupled cluster calculations including singles and doubles excitations, driven by the domain‐based local pair natural orbital approach (DLPNO‐CCSD). Special attention is paid to the definition of a basis set that converges adequately toward the basis set limit for the given property for all methods considered in this study, and a specifically optimized basis set is proposed for this purpose. The results suggest that wave function based methods can supplant but do not outcompete DFT for the calculation of Cu(II) hyperfine coupling constants. Mainstream hybrid functionals such as B3PW91 remain on average the best choice.
Byproducts formed During Thiol‐Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?
Authors: Drogkaris Vasileios , Northrop Brian H. 
Published: November 2020

AbstractThe nucleophile‐initiated mechanism of thiol‐Michael reactions naturally leads to the formation of undesired nucleophile byproducts. Three aza‐Michael compounds representing nucleophile byproducts of thiol‐acrylate reactions initiated by 4‐dimethylaminopyridine (DMAP), 1‐methylimidazole (MIM), and 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) have been synthesized and their reactivity in the presence of thiolate has been investigated. Spectroscopic analysis shows that each nucleophile byproduct reacts with thiolate to produce a desired thiol‐acrylate product along with liberated aprotic amines DMAP, MIM, or DBU, thus demonstrating that these byproducts are reactive rather than persistent. Density functional theoretical computations support experimental observations and predict that a β‐elimination mechanism is favored for converting each nucleophile byproduct into a desired thiol‐acrylate product, though an SN2 process can be competitive (i. e. within <2.5 kcal/mol) in less polar solvents.
Using Human Primary Foreskin Fibroblasts to Study Cellular Damage and Mitochondrial Dysfunction
Authors: Nadalutti Cristina A. , Wilson Samuel H. 
Published: November 2020

AbstractSeveral cell lines of different origin are routinely used in research and drug development as important models to study human health and disease. Studying cells in culture represents an easy and convenient tool to approach complex biological questions, but the disadvantage is that they may not necessarily reflect what is effectively occurring in vivo. Human primary cells can help address this limitation, as they are isolated directly from human biological samples and can preserve the morphological and functional features of their tissue of origin. In addition, these can offer more relevant data and better solutions to investigators because they are not genetically manipulated. Human foreskin tissue discarded after surgery, for instance, represents a precious source for isolating such cells, including human foreskin fibroblasts (FSK), which are used in several areas of research and medicine. The overall health of cells is determined by the mitochondria. Alterations of cellular metabolism and cell death pathways depend, in part, on the number, size, distribution, and structure of mitochondria, and these can change under different cellular and pathological conditions. This highlights the need to develop accurate approaches to study mitochondria and evaluate their function. Here, we describe three easy, step‐by‐step protocols to study cellular viability and mitochondrial functionality in FSK. We describe how to use circumcision tissue obtained from the clinic to isolate FSK cells by mechanical and enzymatic disaggregation, how to use a cationic dye, crystal violet, which is retained by proliferating cells, to determine cell viability, and how to prepare samples to assess the metabolic status of cells by evaluating different mitochondrial parameters with transmission electron microscopy. We have successfully used the approaches outlined here to recapitulate physiological conditions in these cells in order to study the effects of increased intracellular levels of formaldehyde. © 2020 U.S. Government.Basic Protocol 1: Isolation and maintenance of human primary foreskin fibroblasts (FSK)Basic Protocol 2: Determination of cell viability by crystal violet stainingBasic Protocol 3: Transmission electron microscopy to study cellular damage and mitochondrial dysfunction
Characterization of peanut lines with interspecific introgressions conferring late leaf spot resistance
Authors: Lamon Samuele , Chu Ye , Guimaraes Larissa A. , Bertioli David J. , Leal‐Bertioli Soraya C. M. , Santos João F. , Godoy Ignácio J. , Culbreath Albert K. , Holbrook C. Corley , Ozias‐Akins Peggy 
Published: November 2020

AbstractLate leaf spot (LLS) disease caused by Nothopassalora personata (Berk. & M.A. Curtis) U. Braun, C. Nakash, Videira & Crous is prevalent among pathogens encountered in peanut (Arachis hypogaea L.) growing regions. Chemical control is expensive, sometimes inaccessible, and can be difficult to apply. One effective solution to control this disease is the deployment of resistant cultivars. IAC 322 is a breeding line resistant to foliar fungal disease and harbors alien introgressions from A. cardenasii Krapov. & W.C. Gregory, a wild diploid relative of peanut. The objective of this study was to determine the level of LLS resistance conferred by introgressed segments in families derived from TifNV‐High O/L × IAC 322. Phenotyping for LLS resistance was performed under both in vitro and field conditions, which provided sufficient disease pressure to separate the means of susceptible and resistant checks, although there was no statistically significant separation of LLS resistance among the families with introgressions. However, consistent levels of LLS resistance observed in the family with A02‐top/A03‐bottom segments makes it a valuable resource for peanut breeding. In addition, late‐season field disease ratings were found to correlate with the entire LLS infection progression under both field and in vitro conditions. Among the parameters collected for in vitro experiments, numbers of LLS lesions and sporulating LLS lesions at late stages of LLS infection and incubation period can be used to predict LLS resistance under field conditions.
Comprehensive Phenotyping of Human Dendritic Cells and Monocytes
Authors: Mair Florian , Liechti Thomas 
Published: November 2020

AbstractProfessional antigen‐presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T‐cell responses. Recent technological developments in single‐cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue‐specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine‐grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report, we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system.
Pharmacokinetics of salmeterol and its main metabolite α‐hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance‐trained men: Implications for doping control
Authors: Jessen Søren , Becker Victoria , Rzeppa Sebastian , Backer Vibeke , Bengtsen Kasper Høtoft , Hullstein Ingunn , Dehnes Yvette , Hostrup Morten 
Published: November 2020

AbstractAs of 2020, use of beta2‐agonist salmeterol is restricted by the World Anti‐Doping Agency (WADA) and is only permitted by inhalation at therapeutic doses not exceeding 200 μg in 24 h. In contrast to beta2‐agonists salbutamol and formoterol, WADA has not established a urine threshold for salmeterol despite its muscle hypertrophic actions observed in animals. Herein, we investigated plasma (0–4 h) and urine (0–24 h) concentrations (by ultra‐high‐performance liquid chromatography–tandem mass spectrometry [UHPLC–MS/MS]) of salmeterol and α‐hydroxysalmeterol after dry powder inhalation at supratherapeutic (400 μg) and high therapeutic (200 μg) doses, and after seven consecutive days of therapeutic inhalation (200 μg × day−1) in 11 healthy endurance‐trained men. During each trial, participants inhaled salmeterol before 1½ h moderate‐intensity cycling. Mean ± SD maximum urine concentrations of salmeterol unadjusted for specific gravity reached 4.0 ± 1.6, 2.1 ± 1.5, and 2.2 ± 1.1 ng × ml−1 for 400 μg, 200 μg, and seven consecutive days of 200 μg, respectively, with corresponding maximum urine concentrations of α‐hydroxysalmeterol being 11.6 ± 6.1, 5.7 ± 4.6, and 6.5 ± 2.6 ng × ml−1. Within the relevant window for doping control (first 6 h post‐inhalation), the present data (119 samples), along with 64 biobank urine samples, showed that a combined salmeterol and α‐hydroxysalmeterol urine threshold with equal cut‐offs of 3.3 ng × ml−1 was superior to a salmeterol‐only threshold to discriminate therapeutic (200 μg) from supratherapeutic use (400 μg) with a sensitivity of 24% with 0% false positives when applying the WADA technical document (TD2019DL.v2) method of specific gravity adjustment. Thus, a combination of urine salmeterol and α‐hydroxysalmeterol concentrations may be suitable for discriminating between therapeutic and supratherapeutic prohibited inhalation of salmeterol.
Ecological models for estimating breakpoints and prediction intervals
Authors: Tomal Jabed H. , Ciborowski Jan J. H. 
Published: November 2020

Abstract

The relationships between an environmental variable and an ecological response are usually estimated by models fitted through the conditional mean of the response given environmental stress. For example, nonparametric loess and parametric piecewise linear regression model (PLRM) are often used to represent simple to complex nonlinear relationships. In contrast, piecewise linear quantile regression models (PQRM) fitted across various quantiles of the response can reveal nonlinearities in its range of variation across the explanatory variable.

We assess the number and positions of candidate breakpoints using loess and compare the relative efficiencies of PLRM and PQRM to quantitatively determine the breakpoints' location and precision. We propose a nonparametric method to generate bootstrap confidence intervals for breakpoints using PQRM and prediction bands for loess and PQRM. We illustrated the applications using data from two aquatic studies suspected to exhibit multiple environmental breakpoints: relating a fish multimetric index of community health (MMI) to agricultural activity in wetlands' adjacent drainage basins; and relating cyanobacterial biomass to total phosphorus concentration in Canadian lakes.

Two statistically significant breakpoints were detected in each dataset, demarcating boundaries of three linear segments, each with markedly different slopes. PQRM generated less biased, more accurate, and narrower confidence intervals for the breakpoints and narrower prediction bands than PLRM, especially for small samples and large error variability. In both applications, the relationship between the response and environmental variables was weak/nonsignificant below the lower threshold, strong through the midrange of the environmental gradient, and weak/nonsignificant beyond the upper threshold.

We describe several advantages of PQRM over PLRM in characterizing environmental relationships where the scatter of points represents natural environmental variation rather than measurement error. The proposed methodology will be useful for detecting multiple breakpoints in ecological applications where the limits of variation are as important as the conditional mean of a function.
Silicon migration seal wafer‐level vacuum encapsulation
Authors: Suzuki Yukio , Dupuit Victor , Kojima Toshiya , Kanamori Yoshiaki , Tanaka Shuji 
Published: November 2020

AbstractSilicon migration seal (SMS) wafer‐level packaging is proposed for high vacuum encapsulation of MEMS. The sealing of vent holes is possible based on silicon surface migration effect at 1100°C in 100% hydrogen ambient without deposition, if the size of the vent holes is properly designed. The feasibility of SMS packaging was experimentally demonstrated using 4‐inch wafers. Hermetic sealing was confirmed after 168 hours from the packaging process by diaphragm displacement in the cap wafer.