bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of two weeks high-intensity interval training on fasting glucose, glucose tolerance and insulin resistance in adolescent boys: a pilot study
Authors: Cockcroft Emma J. , Bond Bert , Williams Craig A. , Harris Sam , Jackman Sarah R. , Armstrong Neil , Barker Alan R. 
Published: December 2019

Abstract
Background
Current evidence of metabolic health benefits of high-intensity interval training (HIIT) are limited to longer training periods or conducted in overweight youth. This study assessed 1) fasting and postprandial insulin and glucose before and after 2 weeks of HIIT in healthy adolescent boys, and 2) the relationship between pre intervention health outcomes and the effects of the HIIT intervention.

Methods
Seven healthy boys (age:14.3 ± 0.3 y, BMI: 21.6 ± 2.6, 3 participants classified as overweight) completed 6 sessions of HIIT over 2 weeks. Insulin resistance (IR) and blood glucose and insulin responses to a Mixed Meal Tolerance Test (MMTT) were assessed before (PRE), 20 h and 70 h after (POST) the final HIIT session.

Results
Two weeks of HIIT had no effect on fasting plasma glucose, insulin or IR at 20 h and 70 h POST HIIT, nor insulin and glucose response to MMTT (all P > 0.05). There was a strong negative correlation between PRE training IR and change in IR after HIIT (r = − 0.96, P < 0.05).

Conclusion
Two weeks of HIIT did not elicit improvements to fasting or postprandial glucose or insulin health outcomes in a group of adolescent boys. However the negative correlation between PRE IR and improvements after HIIT suggest that interventions of this type may be effective in adolescents with raised baseline IR.
Autism and family involvement in the right to education in the EU: policy mapping in the Netherlands, Belgium and Germany
Authors: van Kessel Robin , Roman-Urrestarazu Andres , Ruigrok Amber , Holt Rosemary , Commers Matt , Hoekstra Rosa A. , Czabanowska Katarzyna , Brayne Carol , Baron-Cohen Simon 
Published: December 2019

Abstract
Introduction
In recent years, the universal right to education has been emphasised by the Universal Declaration on Human Rights and the Convention on the Rights of Persons with Disabilities. In this paper, we mapped policies relevant to special education needs and parental involvement of children with autism at an international level and in the Netherlands, Germany and Belgium.

Methods
A policy path analysis was performed using a scoping review as an underlying methodological framework. This allowed for a rapid gathering of available data from which a timeline of adopted policies was derived.

Results and discussion
Internationally, the universal right to education has been reinforced repeatedly and the values of the Universal Declaration of Human Rights have been reiterated with every reinforcement. Also, the additional support that a child with special education needs requires is acknowledged and measures are taken to facilitate access to any education for all children. There are slight cross-country differences between the countries under study, attributable to differences in national regulation of education. However, all countries have progressed to a state where the right to education for all children is integrated on a policy level and measures are taken to enable children with special needs to participate in education. Recently, an attempt to implement a form of inclusive education was made as a form of special needs provision. Nevertheless, nowhere has this been implemented successfully yet.

Conclusion
The Universal Declaration of Human Rights was a critical juncture in international policy and created an environment where the universal right to education has been implemented for all children in the countries under study.
Using submerged fermentation to fast increase N6-(2-hydroxyethyl)-adenosine, adenosine and polysaccharide productions of Cordyceps cicadae NTTU 868
Authors: Ke Bo-Jun , Lee Chun-Lin 
Published: December 2019

AbstractCordyceps cicadae is a well-known traditional Chinese medicine for treating palpitations and eye diseases. It contains several bioactive compounds such as adenosine, N6-(2-hydroxyethyl)-adenosine (HEA), and polysaccharide. Those bioactive compounds have been reported to perform anti-oxidation and anti-inflammatory properties and provide renal protection. In this study, we researched different fermentation conditions in order to enhance the biomass, adenosine, HEA, and polysaccharide productions of C. cicadae NTTU 868. Solid fermentation was carried out with different grain substrates (barley, oat, rice and wheat). Various submerged fermentation scales were used to produce the C. cicadae NTTU 868 mycelium. The results of solid fermentation revealed that C. cicadae NTTU 868 produced higher adenosine and HEA concentrations in oat rather than in other substrates. C. cicadae NTTU 868 mycelium had obtained the highest concentrations of adenosine and HEA on Day 2 as using the small-scale submerged fermentation. Furthermore, potato dextrose broth with extra 0.2% of yeast extract was able to result in higher HEA concentration. In conclusion, using submerged fermentation to culture C. cicadae NTTU 868 resulted in more efficient adenosine, HEA, and polysaccharide productions than using solid-fermentation, especially when 0.2% of yeast extract was used in the PDB. Importantly, this can be easily scaled-up in the fermentation industry.
TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts
Authors: Vallée Alexandre , Lecarpentier Yves 
Published: December 2019

AbstractMyofibroblasts are non-muscle contractile cells that play a key physiologically role in organs such as the stem villi of the human placenta during physiological pregnancy. They are able to contract and relax in response to changes in the volume of the intervillous chamber. Myofibroblasts have also been observed in several diseases and are involved in wound healing and the fibrotic processes affecting several organs, such as the liver, lungs, kidneys and heart. During the fibrotic process, tissue retraction rather than contraction is correlated with collagen synthesis in the extracellular matrix, leading to irreversible fibrosis and, finally, apoptosis of myofibroblasts. The molecular motor of myofibroblasts is the non-muscle type IIA and B myosin (NMMIIA and NMMIIB). Fibroblast differentiation into myofibroblasts is largely governed by the transforming growth factor-β1 (TGF-β1). This system controls the canonical WNT/β-catenin pathway in a positive manner, and PPARγ in a negative manner. The WNT/β-catenin pathway promotes fibrosis, while PPARγ prevents it. This review focuses on the contractile properties of myofibroblasts and the conductor, TGF-β1, which together control the opposing interplay between PPARγ and the canonical WNT/β-catenin pathway.
Nurses’ perspectives on human rights when coercion is used in psychiatry: a systematic review protocol of qualitative evidence
Authors: Pariseau-Legault Pierre , Vallée-Ouimet Sandrine , Goulet Marie-Hélène , Jacob Jean-Daniel 
Published: December 2019

AbstractBackgroundThe World Health Organization describes the perpetuation of human rights violations against people with mental health problems as a global emergency. Despite this observation, recent studies suggest that coercive measures, such as seclusion, restraints, involuntary hospitalization, or involuntary treatment, are steadily or increasingly being used without proof of their effectiveness. In nursing, several literature reviews have focused on understanding nurses’ perspectives on the use of seclusion and restraints. Although many studies describe the ethical dilemmas faced by nurses in this context, to this date, their perspectives on patient’s rights when a broad variety of coercive measures are used are not well understood. The aim of this review is to produce a qualitative synthesis of how human rights are actually integrated into psychiatric and mental health nursing practice in the context of coercive work.MethodsNoblit and Hare’s meta-ethnographic approach will be used to conduct this systematic review. The search will be conducted in CINAHL, Medline, PsycINFO, ERIC, and Scopus databases, using the PICo model (Population, phenomenon of Interest, Context) and a combination of keywords and descriptors. It will be complemented by a manual search of non-indexed articles, gray literature, and other applicable data sources, such as human rights related documents. Qualitative and mixed-method study designs will be included in this review. Empirical and peer-reviewed articles published between 2008 and 2019 will be selected. Articles will be evaluated independently by two reviewers to determine their inclusion against eligibility criteria. The quality of the selected papers will then be independently evaluated by two reviewers, using the Joanna Briggs Institute’s Checklist for Qualitative Research. Data extraction and content analysis will focus on first- and second-order constructs, that is, the extraction of research participants’ narratives and their interpretation.DiscussionThis review will provide a synthesis of how psychiatric and mental health nurses integrate human rights principles into their practice, as well as it will identify research gaps in this area. The results of this review will then provide qualitative evidence to better understand how nurses can contribute to the recognition, protection, and advocate for human rights in a psychiatric context.Systematic review registrationPROSPERO,CRD42019116862
Singular traveling wave solutions for Boussinesq equation with power law nonlinearity and dual dispersion
Authors: Zheng Shan , Ouyang Zhengyong , Wu Kuilin 
Published: December 2019

AbstractIn this paper we study the Boussinesq equation with power law nonlinearity and dual dispersion which arises in fluid dynamics. A particular kind of product of distributions is introduced and applied to solve non-smooth solutions of this equation. It is proved that, under certain conditions, a distribution solution as a singular Dirac delta function exists for this model. For the first time, this kind of product of distributions is used to deal with a fourth order nonlinear partial differential equation.
Spatially explicit statistical modeling of random and systematic land cover transitions in the main grassland plain of Nech Sar National Park, Ethiopia
Authors: Deribew Kiros Tsegay 
Published: December 2019

AbstractThe main grassland plain of Nech Sar National Park (NSNP) is a federally managed protected area in Ethiopia designated to protect endemic and endangered species. However, like other national parks in Ethiopia, the park has experienced significant land cover change over the past few decades. Indeed, the livelihoods of local populations in such developing countries are entirely dependent upon natural resources and, as a result, both direct and indirect anthropogenic pressures have been placed on natural parks. While previous research has looked at land cover change in the region, these studies have not been spatially explicit and, as a result, knowledge gaps in identifying systematic transitions continue to exist. This study seeks to quantify the spatial extent and land cover change trends in NSNP, identify the strong signal transitions, and identify and quantify the location of determinants of change. To this end, the author classifies panchromatic aerial photographs in 1986, multispectral SPOT imagery in 2005, and Sentinel imagery in 2019. The spatial extent and trends of land cover change analysis between these time periods were conducted. The strong signal transitions were systematically identified and quantified. Then, the basic driving forces of the change were identified. The locations of these transitions were also identified and quantified using the spatially explicit statistical model. The analysis revealed that over the past three decades (1986–2019), nearly 52% of the study area experienced clear landscape change, out of which the net change and swap change attributed to 39% and 13%, respectively. The conversion of woody vegetation to grassland (~ 5%), subsequently grassland-to-open-overgrazed land (28.26%), and restoration of woody vegetation (0.76%) and grassland (0.72%) from riverine forest and open-overgrazed land, respectively, were found to be the fully systematic transitions whereas the rest transitions were recorded either partly systematic or random transitions. The location of these most systematic land cover transitions identified through the spatially explicit statistical modeling showed drivers due to biophysical conditions, accessibility, and urban/market expansions, coupled with successive government policies for biodiversity management, geo-politics, demographic, and socioeconomic factors. These findings provide important insights into biodiversity loss, land degradation, and ecosystem disruption. Therefore, the model for predicted probability generally suggests a 0.75 km and 0.72 km buffers which are likely to protect forest and grassland from conversion to grassland and open-overgrazed land, respectively.
Immune landscapes associated with different glioblastoma molecular subtypes
Authors: Martinez-Lage Maria , Lynch Timothy M. , Bi Yingtao , Cocito Carolina , Way Gregory P. , Pal Sharmistha , Haller Josephine , Yan Rachel E. , Ziober Amy , Nguyen Aivi , Kandpal Manoj , O’Rourke Donald M. , Greenfield Jeffrey P. , Greene Casey S. , Davuluri Ramana V. , Dahmane Nadia 
Published: December 2019

AbstractRecent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between tumor and immune cells may help drive the development of brain tumors such as glioblastoma multiforme (GBM). Despite significant research into the molecular classification of glioblastoma, few studies have characterized in a comprehensive manner the immune infiltrate in situ and within different GBM subtypes.In this study, we use an unbiased, automated immunohistochemistry-based approach to determine the immune phenotype of the four GBM subtypes (classical, mesenchymal, neural and proneural) in a cohort of 98 patients. Tissue Micro Arrays (TMA) were stained for CD20 (B lymphocytes), CD5, CD3, CD4, CD8 (T lymphocytes), CD68 (microglia), and CD163 (bone marrow derived macrophages) antibodies. Using automated image analysis, the percentage of each immune population was calculated with respect to the total tumor cells. Mesenchymal GBMs displayed the highest percentage of microglia, macrophage, and lymphocyte infiltration. CD68+ and CD163+ cells were the most abundant cell populations in all four GBM subtypes, and a higher percentage of CD163+ cells was associated with a worse prognosis. We also compared our results to the relative composition of immune cell type infiltration (using RNA-seq data) across TCGA GBM tumors and validated our results obtained with immunohistochemistry with an external cohort and a different method. The results of this study offer a comprehensive analysis of the distribution and the infiltration of the immune components across the four commonly described GBM subgroups, setting the basis for a more detailed patient classification and new insights that may be used to better apply or design immunotherapies for GBM.
Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART)
Authors: Quintas-Neves Miguel , Teylan Merilee A. , Besser Lilah , Soares-Fernandes João , Mock Charles N. , Kukull Walter A. , Crary John F. , Oliveira Tiago Gil 
Published: December 2019

AbstractAlzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs). Recently, primary age-related tauopathy (PART) has been described as a new anatomopathological disorder where NFTs are the main feature in the absence of neuritic plaques. However, since PART has mainly been studied in post-mortem patient brains, not much is known about the clinical or neuroimaging characteristics of PART. Here, we studied the clinical brain imaging characteristics of PART focusing on neuroanatomical vulnerability by applying a previously validated multiregion visual atrophy scale. We analysed 26 cases with confirmed PART with paired clinical magnetic resonance imaging (MRI) acquisitions. In this selected cohort we found that upon correcting for the effect of age, there is increased atrophy in the medial temporal region with increasing Braak staging (r = 0.3937, p = 0.0466). Upon controlling for Braak staging effect, predominantly two regions, anterior temporal (r = 0.3638, p = 0.0677) and medial temporal (r = 0.3836, p = 0.053), show a trend for increased atrophy with increasing age. Moreover, anterior temporal lobe atrophy was associated with decreased semantic memory/language (r = − 0.5823, p = 0.0056; and r = − 0.6371, p = 0.0019, respectively), as was medial temporal lobe atrophy (r = − 0.4445, p = 0.0435). Overall, these findings support that PART is associated with medial temporal lobe atrophy and predominantly affects semantic memory/language. These findings highlight that other factors associated with aging and beyond NFTs could be involved in PART pathophysiology.
Internet of Things is a revolutionary approach for future technology enhancement: a review
Authors: Kumar Sachin , Tiwari Prayag , Zymbler Mikhail 
Published: December 2019

AbstractInternet of Things (IoT) is a new paradigm that has changed the traditional way of living into a high tech life style. Smart city, smart homes, pollution control, energy saving, smart transportation, smart industries are such transformations due to IoT. A lot of crucial research studies and investigations have been done in order to enhance the technology through IoT. However, there are still a lot of challenges and issues that need to be addressed to achieve the full potential of IoT. These challenges and issues must be considered from various aspects of IoT such as applications, challenges, enabling technologies, social and environmental impacts etc. The main goal of this review article is to provide a detailed discussion from both technological and social perspective. The article discusses different challenges and key issues of IoT, architecture and important application domains. Also, the article bring into light the existing literature and illustrated their contribution in different aspects of IoT. Moreover, the importance of big data and its analysis with respect to IoT has been discussed. This article would help the readers and researcher to understand the IoT and its applicability to the real world.
Childhood adversities and prior involvement with child protective services
Authors: Suglia Shakira F. , Kulick Erin R. , Brown Jocelyn 
Published: December 2019

Abstract
Objectives
We aimed to determine the relation between childhood adversities and prior involvement with Child Protective Services (CPS) history among children presenting for evaluation at a Child Advocacy Center.

Study design
The study evaluated children presenting to a Child Advocacy Center (CAC) from 2009 to 2014. A five-item child adversity measure, based on mother’s report, was characterized into a scale of none, one, or two or more adversities. Caseworkers at the CAC assessed whether families had a prior history of involvement with CPS.

Results
Among the 727 children included in the analyses, 43% had a prior history of involvement with CPS. Twenty-six percent of the children experienced one childhood adversity while 29% experienced two or more. In regression analyses adjusting for socio-demographics, experiencing one (Prevalence Ratio (PR) 1.25 95%CI 1.0–1.5) or two or more adversities (PR1.67 95%CI 1.4, 2.0) was associated with higher prevalence of CPS history compared to those who reported none.

Conclusions
Childhood adversities are associated with prior contact with CPS, suggesting there are missed opportunities to provide services to high-risk families. CACs may be in a unique position to advocate for families and prevent further victimization of children.
Statistical analysis of low-latitude spread F observed over Puer, China, during 2015–2016
Authors: Lan Ting , Jiang Chunhua , Yang Guobin , Zhang Yuannong , Liu Jing , Zhao Zhengyu 
Published: December 2019

AbstractStatistical analysis of spread F (SF), recorded at Puer (PUR, 22.7° N, 101.05° E, Dip Latitude 12.9° N) during 2015–2016, was carried out to reveal its characteristics at the northern equatorial ionization anomaly. In our study, SF was categorized into four types, frequency spread F (FSF), range spread F (RSF), mix spread F (MSF) and strong range spread F (SSF). The statistical results presented that FSF and MSF were dominant over Puer. Most types of SF appeared mostly in summer months, except the maximum occurrence of SSF in equinox months. Moreover, observations of SF events also showed that the solar activity and magnetic activity dependence of SF varied with seasons. Compared with observations at other region, the present results suggest that medium-scale traveling ionospheric disturbances (MSTIDs) may play a key role in generation of SF in low-latitude region.
RECIST and CHOI criteria in the evaluation of tumor response in patients with metastatic colorectal cancer treated with regorafenib, a prospective multicenter study
Authors: Lucidarme Olivier , Wagner Mathilde , Gillard Paul , Kim Stefano , Bachet Jean-Baptiste , Rousseau Benoit , Mazard Thibault , Louvet Christophe , Chibaudel Benoist , Cohen Romain , Garcia-Larnicol Marie-Line , Gobert Aurelien , Henriques Julie , André Thierry 
Published: December 2019

Abstract
Background
To evaluate the objective response rate (ORR) at 2 months of treatment with regorafenib according to RECIST 1.1, Choi, and modified Choi (mChoi) criteria in patients with metastatic colorectal cancer (mCRC).

Methods
Baseline and 2-month contrast-enhanced computed-tomography (CECT) scans of 55 patients with mCRC, prospectively enrolled in phase II TEXCAN trial, were centrally assessed. The primary endpoint was 2-month ORR by RECIST 1.1, Choi, and mChoi criteria. Final outcome was overall survival (OS).

Results
Of 55 patients included in this study (Intention-to-treat [ITT1] population), 35 had CECT at 2 months (ITT2 population). According to RECIST 1.1 criteria, 20 (57%) patients were SD and 15 were PD (43%) in the ITT2 population. According to Choi criteria, 18 (51%) patients were responders and 17 (48%) were non-responders. Median OS was 5.3 months (95% CI 3.7–8.6) in the ITT1 population and 8.9 months (95% CI 5.1–12.6) in the ITT2 population. In the ITT2 population, median OS was 16 months (95% CI 6.6–17.5) in SD patients (n = 20) and 4.6 months (95% CI 3.3–5.8) in PD patients (n = 15), according to RECIST 1.1 criteria (HR = 6.48). Median OS was 7.9 months (95% CI 4.2–17.5) in responders (n = 18) and 9.9 months (95% CI 3.7-NA) in non-responders (n = 17) according to Choi criteria (HR = 1.06). All patients except one were classified as non-responders with mChoi criteria.

Conclusion
At 2 months, unlike RECIST 1.1, Choi and mChoi criteria could not identify mCRC patients with regorafenib survival benefit.

Trial registration
ClinicalTrials.gov Identifier: NCT02699073.Registered March 4, 2016, Retrospectively registered.