bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of Unmanned Aerial Vehicles for CASEVAC in the future urban and littoral environments
Authors: McKnight G , Palmer M , Khan M 
Published: November 2020

AbstractThe recent development of Unmanned Aerial Vehicles (UAVs) and their potential use for casualty evacuation (CASEVAC) has exciting implications for the United Kingdom Defence Medical Services (DMS). When compared to existing technology, the unique attributes of small size, increased manoeuvrability and lack of a human pilot would be extremely useful in congested and hazardous settings. There are ethical and practical considerations to be taken into account, but harnessing the full potential of this technology may improve the chances of survival from some battlefield injuries.UAVs could be of most benefit in a congested and complex battlespace, allowing evacuation of casualties from high risk environments. In addition to CASEVAC, a UAV could be used for critical care transfers, Search and Rescue (SAR) and Humanitarian And Disaster Relief (HADR) operations. Given the vast array of potential applications and a lower risk profile compared with current CASEVAC platforms, the DMS should actively monitor the development of UAV technology and plan ahead for integration within current doctrine.
Effect of bodyweight on VerifyNow Aspirin platelet function test: a retrospective review
Authors: Sandler Melissa , Hoang Cuong , Mak Hannah Y , Levitt Michael R 
Published: November 2020

BackgroundAntiplatelet therapy is used to prevent stent thrombosis in intracranial stents, but the optimal dose of aspirin is unknown. This study sought to determine whether the degree of platelet inhibition with aspirin is affected by bodyweight as observed through a platelet reactivity assay.MethodsThis is a retrospective review of patients who underwent neurovascular stent placement and had a VerifyNow Aspirin assay result. The primary outcome was the correlation between the VerifyNow Aspirin result, bodyweight, and the initial dose of aspirin. Secondary outcomes included the impact of the VerifyNow P2Y12 result and of weight on the incidence of bleeding or a thrombotic event.ResultsOf the 142 included patients, 62.7% weighed ≥70 kg and 88.7% were initiated on aspirin 300–325 mg daily. 83.8% achieved a therapeutic VerifyNow Aspirin result. There was minimal correlation between the VerifyNow Aspirin result, bodyweight, and aspirin dose (R2=0.02). Between patients who weighed <70 kg versus ≥70 kg, there was no difference in the mean aspirin reaction units (ARU) (449 vs 435, p=0.32) or in the incidence of bleeding (28% vs 17.1%, p=0.14) or a thrombotic event (4% vs 5.3%, p=0.59). No patient experienced stent thrombosis and eight patients experienced in-stent stenosis. In a multivariate analysis, only the VerifyNow P2Y12 result predicted the development of either bleeding or a thrombotic event (p<0.01).ConclusionsBodyweight did not influence the likelihood of obtaining a therapeutic VerifyNow Aspirin result. The clinical utility of obtaining VerifyNow Aspirin assays for this patient population is unknown.
Effect of exercise on sleep and bi-directional associations with accelerometer-assessed physical activity in men with obesity
Authors: Plekhanova Tatiana , Rowlands Alex V. , Davies Melanie , Edwardson Charlotte L. , Hall Andrew , Yates Thomas 
Published: November 2020

This study examined the effect of exercise training on sleep duration and quality and bidirectional day-to-day relationships between physical activity (PA) and sleep. Fourteen inactive men with obesity (age: 49.2 ± 7.9 years, body mass index: 34.9 ± 2.8 kg/m2) completed a baseline visit, 8-week aerobic exercise intervention, and 1-month post-intervention follow-up. PA and sleep were assessed continuously throughout the study duration using wrist-worn accelerometry. Generalised estimating equations were used to examine associations between PA and sleep. Sleep duration increased from 5.2 h at baseline to 6.6 h during the intervention period and 6.5 h at 1-month post-intervention follow-up (p < 0.001). Bi-directional associations showed that higher overall activity volume and moderate-to-vigorous physical activity (MVPA) were associated with earlier sleep onset time (p < 0.05). Later timing of sleep onset was associated with lower overall volume of activity, most active continuous 30 min (M30CONT), and MVPA (p < 0.05). Higher overall activity volume, M30CONT, and MVPA predicted more wake after sleep onset (WASO) (p < 0.001), whereas greater WASO was associated with higher overall volume of activity, M30CONT, and MVPA (p < 0.001). An aerobic exercise intervention increased usual sleep duration. Day-to-day, more PA predicted earlier sleep onset, but worse sleep quality and vice versa. Novelty: Greater levels of physical activity in the day were associated with an earlier sleep onset time that night, whereas a later timing of sleep onset was associated with lower physical activity the next day in men with obesity. Higher physical activity levels were associated with worse sleep quality, and vice versa.
Developing a Parental-Friendly Scoring System for Children with Congenital Hand Differences
Authors: Lam Wee Leon , Trew Christopher Arthur James , Wong Lauren , Gall Christopher , Duncan Orla , Teo Isabel 
Published: November 2020

Background: Congenital hand differences (CHD) exhibit enormous diversity and heterogeneity. Surgeons and parents often have different concepts of severity, making things difficult during parental consultation. This study aims to align surgeon/parental views on the severity of the child’s CHD using a novel severity classification. Methods: Parents of affected children were asked to score the severity of their child’s abnormality pre- and post-consultation using a subjective scale (1–4) without any explanation. Furthermore, parents were asked to rate their concerns about the future function and appearance of their child’s hand condition using a similar scale of 1–4. They were then asked to rate the severity of the CHD post-consultation and three months post-operatively following explanation of the 4-point scale, as follows: 1 = treatment possible to normal; 2 = treatment possible to near normal; 3 = treatment possible but always some hand differences; 4 = treatment not possible. The surgeon also independently scored all children using his perception of the scale. Results: Forty-three children with a range of CHD were recruited into the sample. Linear weighted kappa analyses comparing inter-rater agreement showed no agreement between surgeon and parents during the initial scoring without any explanations. However, with explanations added, agreement rose significantly (kappa = 0.437 post-consultation and kappa = 0.706 three months post-op). No correlation was found between severity with both appearance and function (r = 0.277 and r = −0.184, respectively). Conclusions: This study demonstrated that the use of a simple scoring system was able to improve parental understanding of the severity and prognosis of CHD. The system demonstrated a good correlation between surgeon and parents. Such a scoring system can be easily utilised in the outpatient department to manage expectations and reduce anxiety.
Follicular Fluid Meiosis-Activating Sterol in Assisted Reproductive Techniques: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Dang Kien Nguyen , Hashan Mohammad Rashidul , Minh Le Huu Nhat , Khalaf Khalid Muhammad , Ibrahim Hassan Yousif , Dessi Alberto , Azzam Mohamed Abdalla , Loc Tran Thai Huu , Hirayama Kenji , Huy Nguyen Tien 
Published: November 2020

Background: Follicular fluid meiosis-activating sterol (FFMAS) is one of several molecular compounds that has been added into in vitro maturation (IVM) technique with contradictory results. Our study aimed to investigate the effects of FFMAS in assisted reproductive technology (ART). Methods: We searched systematically in PubMed, Web of Science, Scopus, Cochrane Registry of clinical trials, WHO registry of clinical trials, clinicaltrials.gov, Google Scholar until July 2017. Meta-analysis was used to investigate the efficacy and safety outcomes of FFMAS. Following the retrieval of potential articles, two independent reviewers screened and extracted included papers rigorously. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were computed for the individual outcome when data was available. Quality of included studies was assessed using Cochrane collaboration tool. Results: A total of seven randomized controlled trials involving 1198 participants with 3105 oocytes were explored in this study. Most of the studies were at low risk of bias. Our random effects model meta-analyses in maturation and abnormal embryo rate between FFMAS-exposed oocytes compared with controls revealed no significant differences (summary OR 1.00, 95% CI 0.46–2.16, [Formula: see text] value = 0.99 and summary OR was 1.31, 95% CI 0.84–2.04, [Formula: see text] value = 0.23, respectively). Beside, our study showed a significant increase in uniformly abnormal embryo rate in FFMAS group compared with vehicle control group (summary OR 1.98, 95% CI 1.09–3.61, [Formula: see text] value = 0.03). No significances were noted on meta-analyses of normal embryo rate, uniformly abnormal embryo rate, uniformly normal embryo rate, mosaic embryo rate, abnormal blastomere rate, normal blastomere rate, aneuploidy mosaic embryo rate, and chaotic mosaic embryo rate. Conclusions: FFMAS showed no efficacy in maturation process in human oocytes and there was some evidence for detrimental effects in comparison to vehicle controls. We discouraged any further trials due to safety concern.
The Challenge of Combining Chemo- and Radiotherapy with Checkpoint Kinase Inhibitors
Authors: van Bijsterveldt Linda , Durley Samuel C. , Maughan Tim S. , Humphrey Timothy C. 
Published: November 2020

Abstract
Preclinical models of cancer have demonstrated enhanced efficacy of cell-cycle checkpoint kinase inhibitors when used in combination with genotoxic agents. This combination therapy is predicted to be exquisitely toxic to cells with a deficient G1–S checkpoint or cells with a genetic predisposition leading to intrinsic DNA replication stress, as these cancer cells become fully dependent on the intra-S and G2–M checkpoints for DNA repair and cellular survival. Therefore, abolishing remaining cell-cycle checkpoints after damage leads to increased cell death in a tumor cell–specific fashion. However, the preclinical success of these drug combinations is not consistently replicated in clinical trials. Here, we provide a perspective on the translation of preclinical studies into rationally designed clinical studies. We will discuss successes and failures of current treatment combinations and drug regimens and provide a detailed overview of all clinical trials using ATR, CHK1, or WEE1 inhibitors in combination with genotoxic agents. This highlights the need for revised patient stratification and the use of appropriate pharmacodynamic biomarkers to improve the success rate of clinical trials.
A simple levelized cost of electricity for EV charging with PV and battery energy storage system: Thailand case study
Authors: Wangsupphaphol Aree , Chaitusaney Surachai 
Published: November 2020

This paper proposes the calculation of the simple levelized cost of electricity of PV and battery energy storage system for supporting the investment decision of the EV hybrid charging station. The paper introduces the problems of EV charging against the grid power system. Thus, the hybrid charging for EV is suggested. The study provides an architecture of the hybrid EV charging station along with the factor impacting the EV infrastructure for acknowledgment. The cost elements of the station are presented to address the benefits of the investment. Besides, the profit is mainly from the margin of the electricity price, therefore, this study compares the electricity cost of PV and PV equipped with a battery with the commercial on-peak electricity tariff. The results show that the charging cost contributed by PV alone has the lowest amount throughout the study period year 2020 – 2030. In contrast, the hybrid charging cost contributed by PV and battery has a higher value than the on-peak tariff during 2020 – 2025 but it is lower afterward. The result supports the feasibility of charging an EV by solar power and the hybrid power system in the future.
A neotype for Hyla x-signata Spix, 1824 (Amphibia, Anura, Hylidae)
Authors: Araujo-Vieira Katyuscia , Pombal Jr. José P. , Caramaschi Ulisses , Novaes-e-Fagundes Gabriel , Orrico Victor G.D. , Faivovich Julián 
Published: November 2020

The uncertain identity of Hyla x-signata Spix, 1824 has been a pervasive problem in the taxonomy of the genus Scinax. A species supposedly distributed from northeastern Brazil northwards to Colombia and Venezuela, described in a few lines without much information and with an accompanying figure, and its type specimen lost during World War II, combined to produce a curious situation. Twenty-one of the 39 species of the S. ruber Clade described in the last 50 years were considered to require a diagnosis from S. x-signatus by their authors. In most cases these had no other alternative than to gather information about this species from indirect sources, frequently pointing out the problems associated with its uncertain identity. In this paper, we review the taxonomic history of Hyla x-signata, designate a neotype, provide a redescription including advertisement call and sequence data, and diagnose it from all other species of the S. ruber Clade.
A new species of Drymaeus endemic from Currais Archipelago, Paraná, Brazil (Pulmonata, Bulimulidae)
Authors: Simone Luiz Ricardo Lopes de , Belz Carlos Eduardo , Gernet Marcos de Vasconcellos 
Published: November 2020

The new bulimulid species, Drymaeus currais sp. nov., is described based on shell and anatomical features. It is endemic of Guapirá Island, belonging to the Currais Archipelago, a small protected area off Paraná coast. The species is thus, based at least on endemicity, endangered. It has as closest species D. castilhensis, another endemic species of Castilho Island, ~70 km northwards. Its main exclusivities are a banded shell (except for periumbilical area); a ureter ~1/3 opened (furrow); an external anus; a slightly different buccal and intestinal arrangement; a penis lacking internal chambers; a small receptacle with a genital appendix. Zoobank Register: urn:lsid:zoobank.org:pub:25B25A8B-CED0-4284-A799-5383998BE481.
The Chrysidoidea Wasps (Hymenoptera, Aculeata) in Conventional Coffee Crops and Agroforestry Systems in Southeastern Brazil
Authors: Martins André Luis , Lemes José Ricardo Assmann , Lopes Paulo Rogério , Dias Angélica Maria Penteado 
Published: November 2020

Agroforestry systems represent the integration of agricultural crops with native vegetation. These systems are of great importance to minimize the agricultural impact in the land through intercropping of these vegetations. Despite of the importance of Chrysidoidea as parasitoids wasps associated with different groups of insects, there is no study comparing the assemblages of these hymenopterans in conventional and agroforestry systems in Brazil. The “Pontal do Paranapanema”, located in the extreme west of the state of São Paulo (Brazil), has historically been occupied by coffee crops and some small areas of agroforestry systems. Therefore, this study aimed to verify the abundance and composition of Chrysidoidea wasp fauna in different conventional coffee crops and agroforestry systems located in this region. To do so, we collected in six different localities in the “Pontal do Paranapanema” using a Malaise trap in each locality with collections occurring monthly between June 2011 and July 2012. A total of 3,623 Chrysidoidea specimens of three families were collected: Bethylidae, with four genera and a total of 3,396 individuals, representing 93.73% of the total collected; Chrysididae with 11 genera and 151 individuals (4.16%), and Dryinidae with five genera and 76 individuals (2.09%). In terms of abundance, the agroforestry was responsible for most of the individuals collected (n = 2029), followed by the conventional systems with 1,406 individuals and the transitional with 188. The most abundant genera were Epyris and Dissomphalus, responsible for about 92% of the total of Chrysidoidea collected. Most of the genera of Chrysididae were collected in the conventional systems alone or in both conventional and agroforestry systems. For Bethylidae and Dryinidae, no genera were found exclusively in the conventional system. It is expected that the structural complexity of each one of the different ecosystems impact directly in the fauna of Chrysidoidea parasitoids associated.
Anuran diversity of four taxocenoses of the subtropical Atlantic Forest from Santa Catarina and Paraná states Brazil
Authors: Mariotto Lucas Ribeiro 
Published: November 2020

Local fauna inventories provide primary key information on diversity and distribution of species for conservation purposes. The Atlantic Forest holds 50% of anuran species in the country and the main threats to the conservation of this fauna are habitat reduction and fragmentation. The present study brings information on the local richness and species composition of four anuran taxocenoses from the subtropical Atlantic Forest of Paraná and Santa Catarina states, Brazil. Data collection included breeding sites surveys (N = 56) and literature review. Richness and beta diversity were compared through rarefaction/extrapolation curves, local contribution to beta diversity (LCBD), beta partitioning and cluster analysis. Anuran from 46 species were registered and local richness differences were observed on the rarefaction/extrapolation curves and on asymptotic analysis. Nevertheless, the LCBD did not detect differences in species composition among the four taxocenoses. The turnover was the predominant component of beta diversity. The geographical distances explain species composition for all localities compiled in this study. The differences among local richness may be related to environmental impacts, emphasizing the need for conservation of biodiversity in the remnants of Atlantic forest.
Laser‐Assisted Removal of Embedded Vena Cava Filters: A First‐In‐Human Escalation Trial in 500 Patients Refractory to High‐Force Retrieval
Authors: Kuo William T. , Doshi Ankur A. , Ponting John M. , Rosenberg Jarrett K. , Liang Tie , Hofmann Lawrence V. 
Published: November 2020

Background
Many patients are subject to potential risks and filter‐related morbidity when standard retrieval methods fail. We evaluated the safety and efficacy of the laser sheath technique for removing embedded inferior vena cava filters.

Methods and Results

Over an 8.5‐year period, 500 patients were prospectively enrolled in an institutional review board–approved study. There were 225 men and 275 women (mean age, 49 years; range, 15–90 years). Indications for retrieval included symptomatic acute inferior vena cava thrombosis, chronic inferior vena cava occlusion, and/or pain from filter penetration. Retrieval was also offered to prevent risks from prolonged implantation and potentially to eliminate need for lifelong anticoagulation. After retrieval failed using 3X standard retrieval force (6–7 lb via digital gauge), treatment escalation was attempted using laser sheath powered by 308‐nm XeCl excimer laser system (CVX‐300; Spectranetics). We hypothesized that the laser‐assisted technique would allow retrieval of >95% of embedded filters with <5% risk of major complications and with lower force. Primary outcome was successful retrieval. Primary safety outcome was any major procedure‐related complication. Laser‐assisted retrieval was successful in 99.4% of cases (497/500) (95% CI, 98.3%–99.9%) and significantly >95% (
P
<0.0001). The mean filter dwell time was 1528 days (range, 37–10 047; >27.5 years]), among retrievable‐type (n=414) and permanent‐type (n=86) filters. The average force during failed attempts without laser was 6.4 versus 3.6 lb during laser‐assisted retrievals (
P
<0.0001). The major complication rate was 2.0% (10/500) (95% CI, 1.0%–3.6%), significantly <5% (
P
<0.0005), 0.6% (3/500) (95% CI, 0%–1.3%) from laser, and all were successfully treated. Successful retrieval allowed cessation of anticoagulation in 98.7% (77/78) (95% CI, 93.1%–100.0%) and alleviated filter‐related morbidity in 98.5% (138/140) (95% CI, 96.5%–100.0%).

Conclusions
The excimer laser sheath technique is safe and effective for removing embedded inferior vena cava filters refractory to high‐force retrieval. This technique may allow cessation of filter‐related anticoagulation and can be used to prevent and alleviate filter‐related morbidity.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01158482.
Use of Oral Anticoagulation in a Real‐World Population With Device Detected Atrial Fibrillation
Authors: Kaplan Rachel M. , Ziegler Paul D. , Koehler Jodi , Landman Sean , Sarkar Shantanu , Passman Rod S. 
Published: November 2020

Background

Guideline recommendations for oral anticoagulation (OAC) in patients with atrial fibrillation (AF) are based on CHA
2
DS
2
‐VASc score alone. Patients with cardiac implantable electronic devices provide an opportunity to assess how the interaction between AF duration and CHA
2
DS
2
‐VASc score influences OAC prescription rates.

Methods and Results

Data from the Optum de‐identified Electronic Health Record data set were linked to the Medtronic CareLink database of cardiac implantable electronic devices. An index date was assigned as the later of 6 months after device implant or 1 year after Electronic Health Record data availability. Maximum daily AF duration (no AF, 6 minutes–23.5 hours, and >23.5 hours) was assessed for 6 months before index date. OAC prescription rates were computed as a function of both AF duration and CHA
2
DS
2
‐VASc score. A total of 35 779 patients with CHA
2
DS
2
‐VASc scores ≥1 were identified, including 27 198 not prescribed OAC. Overall OAC prescription rate among the 12 938 patients with device‐detected AF >6 minutes was 36.7% and significantly higher in those with a maximum daily AF duration >23.5 hours (45.4%) compared with those with 6 minutes to 23.5 hours (28.7%). OAC prescription rates increased monotonically with both increasing AF duration and CHA
2
DS
2
‐VASc score, reaching a maximum of 67.2% for patients with AF >23.5 hours and a CHA
2
DS
2
‐VASc score ≥5.

Conclusions

Real‐world prescription of OAC increased with both increasing duration of AF and CHA
2
DS
2
‐VASc score. This highlights the need for further research into the role of AF duration, stroke risk, and the need for anticoagulation in patients with devices capable of long‐term AF monitoring.