bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC)
Authors: Gudbrandsdottir Gigja , Aarstad Helene H. , Bostad Leif , Hjelle Karin M. , Aarstad Hans J. , Bruserud Øystein , Tvedt Tor Henrik Anderson , Beisland Christian 
Published: July 2020

Abstract
Purpose
An improved understanding of RCC immunology should shed further light on RCC tumor biology. Our objective was to study to what extent serum levels of the IL-6 family of cytokines at diagnosis were relevant to survival.

Methods
A total of 118 consecutively patients with RCC, in which the tumor was surgically removed at Haukeland University Hospital during the period from 2007 to 2010, were included. The patients were followed-up for 10 years. The morning before surgery blood was sampled and serum frozen, with levels of IL-6, IL-27, IL-31, OSM, CNTF, IL-6Rα and gp130 determined.

Results
Among patients with the highest quartile of IL-6 (> 8 pg/ml) (n = 29), six of nine who had metastasis at diagnosis had such high IL-6 values. Among presumed radically treated patients, a high IL-6 and IL-27 strongly predicted recurrence. In particular, the predictions among patients with large (diameter > 7 cm) tumors were excellent regarding both IL-6 and IL-27 values. High gp130 serum levels predicted an overall survival (OS) among RCC patients with large tumors. Patients with a high IL-6 exhibited a strong expression of IL-6 in endothelial- and vascular smooth muscle cells. Moreover, the level of intra-tumoral CD3-positive cells predicted survival.

Conclusions
IL-6 and IL-27 seem to play a role in RCC biology. IL-6 enables the pinpointing of metastatic condition at diagnosis, as well as together with IL-27, the predicting of survival and recurrence. Endothelial cells and vascular smooth muscle cells are both suggested as important sources of IL-6.
Thermodynamics of the system Fe–Si–O under high pressure and temperature and its implications for Earth’s core
Authors: Komabayashi Tetsuya 
Published: July 2020

AbstractThe thermodynamics of the system Fe–Si–O under high pressure (P) and temperature (T) was examined, starting with modelling the phase transition between a face-centred cubic (fcc) and hexagonal close-packed (hcp) structure in Fe–Si alloy which was previously examined by experiment under high P–T conditions. The mixing properties of Fe and Si for the iron phases were found to be approximated by ideal mixing under high P and T conditions. The entropy changes upon melting of the end-members of the system are fairly large, and therefore the melting temperature of the Si-bearing fcc or hcp phases needs to be insensitive to the Si content, to account for the reported close compositions of coexisting liquid and solid (< 1 wt%Si at P > 50 GPa). The solidus and liquidus temperatures of Fe–Si iron alloy would therefore, not significantly be changed by the presence of Si at the inner core-outer core boundary, which enables us to evaluate the melting curve of Fe–Si fcc and hcp phases. From thus-constrained melting curve, I assessed a thermal equation of state of Si-bearing iron liquid. I then estimated a seismologically consistent outer core composition as a function of Si and O contents using the EoS for liquids constructed in this study and the literature. The best-fit composition is Fe-5.8(0.6) wt%Si–0.8(0.6) wt%O, which however does not precipitate a solid iron phase that is consistent with the inner core density. Therefore, Earth’s core cannot be fully represented by the system Fe–Si–O and it should include another light element.
Rotatable microfluidic device for simultaneous study of bilateral chemosensory neurons in Caenorhabditis elegans
Authors: Chung Jinyang , Brittin Christopher A. , Evans Stephen D. , Cohen Netta , Shim Jung-uk 
Published: July 2020

AbstractThe nematode Caenorhabditis elegans is a leading model system in genetics, development and neurobiology; its transparent body and small size make it particularly suitable for fluorescent imaging of cells and neurons within microfluidic setups. Simultaneously recording activity in bilaterally symmetric cells has proved difficult in C. elegans because the worm enters the chip and is then immobilised when it is lying on one side of the body. We developed a side-view rotatable microfluidic device that allows us to image a pair of bilateral neurons in a single focal plane of an epi-fluorescence microscope. We demonstrated the utility of the device by recording the responses of immobilised worms to controlled stimuli, focusing on the responses of two classes of head sensory neurons to changes in NaCl concentration. The results indicate that responses of ASE left and right and ASH left and right sensory neurons are stochastic. Simultaneous recordings of ASH left and right neurons tend to synchronise, pointing to a role of gap junctional connectivity. The anatomy of the C. elegans nerve ring makes this microfluidic approach ideally suited for the study of spatially extended pairs of neurons or larger neuronal circuits that lie within a limited depth of field.
Licensing, Educational Credentialing, and Wages Among Foreign Skilled Workers in Germany
Authors: Rohrbach-Schmidt Daniela 
Published: July 2020

AbstractThe article studies whether foreign skilled workers have similar access to licensed and more credentialed occupations, and whether they profit from these regulations in terms of similar wages in these occupations to comparable domestic skilled workers. The theoretical foundations of this article are concepts of signaling and occupational closure. The analyses use a sample of 60,000 employed persons from the 2006, 2012 and 2018 Employment Surveys of the German Federal Institute for Vocational Education and Training (BIBB) and the Federal Institute for Occupational Safety and Health (BAuA), and a reweighting approach to account for the selection on observables. Results show an ambivalent picture of the regulation of occupations: on the one hand, at least foreign skilled men earn similar wages to domestic skilled men in more closed occupations; on the other hand, foreign skilled workers are less likely to enter these positions and they have monetary disadvantages compared with domestic skilled workers in less closed occupations.
Implementing Pre-Emptive Managed Retreat: Constraints and Novel Insights
Authors: Lawrence Judy , Boston Jonathan , Bell Robert , Olufson Sam , Kool Rick , Hardcastle Matthew , Stroombergen Adolf 
Published: July 2020

Abstract
Purpose of Review
Managed retreat will be inevitable where other adaptation options, such as protective structures or building restrictions, provide only temporary respite or are otherwise uneconomic, technically impractical or both. Here, we focus on the implementation of pre-emptive managed retreat, providing examples of how it can be sequenced, socialised and given the governance enablers necessary for implementation.

Recent Findings
Ongoing sea-level rise during the twenty-first century and beyond poses huge adaptation challenges, especially for low-lying coastal and floodplain settlements. Settlements are already functionally disrupted from repetitive non-extreme flooding and research shows that sea-level rise will impact far more people, far sooner than previously thought, as more powerful storms, heavy rainfall and rising groundwater coincide with higher tides. To date, most examples of managed retreat have been post-disaster responses following damage and disruption. Pre-emptive managed retreat, by contrast, has yet to become a well-accepted and widely practised adaptation response. Nevertheless, there are increasing examples of research and practice on how pre-emptive managed retreat can be designed, sequenced and implemented alongside other forms of adaptation within anticipatory forms of governance.

Summary
The current state of knowledge about managed retreat is reviewed and critical insights and lessons for governance and policy-making are given. Several novel examples from New Zealand are presented to address some of the implementation gaps. Goals and principles are enunciated to inform long-term adaptation strategies.
Electrodeposited Sulfur and CoxS Electrocatalyst on Buckypaper as High-Performance Cathode for Li–S Batteries
Authors: Zhan Yi , Buffa Andrea , Yu Linghui , Xu Zhichuan J. , Mandler Daniel 
Published: July 2020

Abstract
Lithium–sulfur batteries (LSBs) are considered as the next generation of advanced rechargeable batteries because of their high energy density. In this study, sulfur and CoxS electrocatalyst are deposited on carbon nanotube buckypaper (S/CoxS/BP) by a facile electrodeposition method and are used as a binder-free high-performance cathode for LSBs. Elemental sulfur is deposited on buckypaper by electrooxidation of a polysulfide solution (~ S62−). This approach substantially increased the current and time efficiency of sulfur electrochemical deposition on conductive material for LSBs. S/CoxS/BP cathode could deliver an initial discharge capacity as high as 1650 mAh g−1 at 0.1 C, which is close to the theoretical capacity of sulfur. At current rate of 0.5 C, the S/CoxS/BP has a capacity of 1420 mAh g−1 at the first cycle and 715 mAh g−1 after 500 cycles with a fading rate of 0.099% per cycle. The high capacity of S/CoxS/BP is attributed to both the homogeneous dispersion of nanosized sulfur within BP and the presence of CoxS catalyst. The sodium dodecyl sulfate (SDS) pretreatment of BP renders it polarity to bind polysulfides and thus facilitates the good dispersibility of nanosized sulfur within BP. CoxS catalyst accelerates the kinetics of polysulfide conversion and reduces the presence of polysulfide in the cathode, which suppresses the polysulfide diffusion to anode, i.e., the shuttle effect. The mitigation of the active material loss improves not only the capacity but also the cyclability of S/CoxS/BP.

Graphic Abstract
Parents’ experiences and use of parenting resources during the transition to parenthood
Authors: Sanders Rachael , Lehmann Jennifer , Gardner Fiona 
Published: July 2020

AbstractThe purpose of this paper is to report on new parents’ experiences of using the available range of parenting resources that help to guide parenting choices and practices. Using a semi-structured interview schedule, 30 participants were asked about their engagement with parenting resources. The types of resources considered most salient to the participants of this study in Victoria, Australia, included professional services, peers, family and friends, and written material. On the whole, these parents valued expert opinion when they encountered problems but experienced a level of frustration when they did not ‘feel heard’ by professionals or when faced with mixed messages. While they reported some resistance to overt advice offered by family and friends, especially if the information was considered ‘out-dated’, they relied heavily on informal advice and support from peers, even if this was supported only by anecdotal evidence.
TILTING THEORY FOR GORENSTEIN RINGS IN DIMENSION ONE
Authors: BUCHWEITZ RAGNAR-OLAF , IYAMA OSAMU , YAMAURA KOTA 
Published: July 2020

In representation theory, commutative algebra and algebraic geometry, it is an important problem to understand when the triangulated category$\mathsf{D}_{\operatorname{sg}}^{\mathbb{Z}}(R)=\text{}\underline{\mathsf{CM}}_{0}^{\mathbb{Z}}R$admits a tilting (respectively, silting) object for a$\mathbb{Z}$-graded commutative Gorenstein ring$R=\bigoplus _{i\geqslant 0}R_{i}$. Here$\mathsf{D}_{\operatorname{sg}}^{\mathbb{Z}}(R)$is the singularity category, and$\text{}\underline{\mathsf{CM}}_{0}^{\mathbb{Z}}R$is the stable category of$\mathbb{Z}$-graded Cohen–Macaulay (CM)$R$-modules, which are locally free at all nonmaximal prime ideals of$R$.In this paper, we give a complete answer to this problem in the case where$\dim R=1$and$R_{0}$is a field. We prove that$\text{}\underline{\mathsf{CM}}_{0}^{\mathbb{Z}}R$always admits a silting object, and that$\text{}\underline{\mathsf{CM}}_{0}^{\mathbb{Z}}R$admits a tilting object if and only if either$R$is regular or the$a$-invariant of$R$is nonnegative. Our silting/tilting object will be given explicitly. We also show that if$R$is reduced and nonregular, then its$a$-invariant is nonnegative and the above tilting object gives a full strong exceptional collection in$\text{}\underline{\mathsf{CM}}_{0}^{\mathbb{Z}}R=\text{}\underline{\mathsf{CM}}^{\mathbb{Z}}R$.
Marsupials (Mammalia, Metatheria) from the Brule Formation (Whitneyan, Oligocene) North Dakota
Authors: Korth William W. , Boyd Clint A. , Emry Robert J. , Person Jeff J. 
Published: July 2020

AbstractFive marsupial species are recognized from the Brule Formation at two localities in southwestern North Dakota: Fitterer Ranch and Obritsch Ranch (middle Oligocene; Whitneyan North American Land Mammal Age [NALMA]). The herpetotheriidsHerpetotherium fugaxCope, 1873a,Copedelphys superstesnew species, and the peradectidNanodelphys hunti(Cope, 1873b) are represented at both localities. A fourth species isH. sp., cf.H.merriami(Stock and Furlong, 1922), represented by a single specimen from Fitterer Ranch, being limited elsewhere to the later Arikareean NALMA. A fifth species is represented by two isolated lower cheek teeth, interpreted as m1s, from Fitterer Ranch that are unique in lacking a trigonid (only two cusps present) while having a well-developed talonid. These specimens are referred to an indeterminate herpetotheriine species. The new species ofCopedelphysis distinct from other species of the genus in that the anterior two lower molars are enlarged relative to the posterior molars. Overall, this new species is more similar in proportions to the latest Eocene (Chadronian)C.titanelix(Matthew, 1903) than the Oligocene (Orellan and Whitneyan)C.stevensoni(Cope, 1873b). This study adds a third and fourth Whitneyan marsupial fauna from the Great Plains region of North America, increases the known diversity of Whitneyan marsupials, and provides further evidence that marsupial diversity during the late Paleogene in North America was relatively stable until the late early Arikareean NALMA.UUID:http://zoobank.org/b8534802-b9ed-4120-baca-fc72917f7d6a
Collaborative production networks among unequal actors
Authors: Muñoz-Herrera Manuel , Dijkstra Jacob , Flache Andreas , Wittek Rafael 
Published: July 2020

AbstractWe develop a model of strategic network formation of collaborations to analyze the consequences of an understudied but consequential form of heterogeneity: differences between actors in the form of their production functions. We also address how this interacts with resource heterogeneity, as a way to measure the impact actors have as potential partners on a collaborative project. Some actors (e.g., start-up firms) may exhibit increasing returns to their investment into collaboration projects, while others (e.g., established firms) may face decreasing returns. Our model provides insights into how actor heterogeneity can help explain well-observed collaboration patterns. We show that if there is a direct relation between increasing returns and resources, start-ups exclude mature firms and networks become segregated by types of production function, portrayingdominant grouparchitectures. On the other hand, if there is an inverse relation between increasing returns and resources, networks portraycore-peripheryarchitectures, where the mature firms form a core and start-ups with low-resources link to them.
Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study
Authors: Long Jing-An , Zhong Rong-Huan , Chen Si , Wang Fan , Luo Yun , Lu Xiao-Ting , Yishake Dinuerguli , Chen Yu-Ming , Fang Ai-Ping , Zhu Hui-Lian 
Published: July 2020

AbstractA higher dietary intake or serum concentration of betaine has been associated with greater lean body mass in middle-aged and older adults. However, it remains unknown whether betaine intake is associated with age-related loss of skeletal muscle mass (SMM). We assessed the association between dietary betaine intake and relative changes in SMM after 3 years in middle-aged adults. A total of 1242 participants aged 41–60 years from the Guangzhou Nutrition and Health Study 2011–2013 and 2014–2017 with body composition measurements by dual-energy X-ray absorptiometry were included. A face-to-face questionnaire was used to collect general baseline information. After adjustment for potential confounders, multiple linear regression found that energy-adjusted dietary betaine intake was significantly and positively associated with relative changes (i.e. percentage loss or increase) in SMM of legs, limbs and appendicular skeletal mass index (ASMI) over 3 years of follow-up (β 0·322 (se 0·157), 0·309 (se 0·142) and 0·303 (se 0·145), respectively; P < 0·05). The ANCOVA models revealed that participants in the highest betaine tertile had significantly less loss in SMM of limbs and ASMI and more increase in SMM of legs over 3 years of follow-up, compared with those in the bottom betaine tertile (all Ptrend < 0·05). In conclusion, our findings suggest that elevated higher dietary betaine intake may be associated with less loss of SMM of legs, limbs and ASMI in middle-aged adults.
TRANSFORMINGARMA VIRVMQVE: SYNTACTICAL, MORPHOLOGICAL AND METRICAL DIS-MEMBRA-MENT IN STATIUS’THEBAID
Authors: Dalton Helen E.B. 
Published: July 2020

Arma uirumque cano… ‘Je chante les armes et l'homme …’ ainsi commence l’Énéide, ainsi devrait commencer toute poésie.It is far from an overstatement to make the claim that in the surviving corpus of Latin poetry no phrase is more immediately identifiable than the pronouncement of the Virgilian narrator on the ‘arms and the man’ of his subject matter. The presence ofarma uirumquein a particular formation cannot fail to put us in mind of theAeneidand its concomitant ideological associations. A consequence of the epic's centrality as a canonical text was the emergence in antiquity ofarma uirumqueas a synecdochic quotation for the work as a whole and, as such, for the figure of the poet himself. This transformation was further actuated by the ancient practice of ascribing titular authority to a poem's incipit, ensuring that arms and the man took on especial resonance. Even within theAeneid, self-referential intratextual play with the Virgilian utterance can be detected. Furthermore, in post-Augustan verse, Fowler argues thatarmaalone is always loaded in a metaliterary fashion, serving as an identifying marker for Virgil's epic or, more broadly, for epic in general. This was so marked a phenomenon that the opening word of the poem was recycled and reworked by Ovid around a decade after the compositional beginnings of theAeneid, in the first book of theAmores, in what formed an announcement of the redeployment of epicarmainto the elegiac world ofmilitia amoris(Am. 1.1–2).
COMPARATIVE CONSTITUTIONAL INTERPRETATION OF RELIGIOUS FREEDOM
Authors: Smet Stijn 
Published: July 2020

AbstractWhen adjudicating religious disputes, constitutional courts often resort to a particular discursive register. The notions ‘tolerance’ and ‘respect’ are an integral part of this religion-specific constitutional register. But what do judges mean when they deploy the language of tolerance and respect? And what substantive role, if any, do both notions play in the constitutional interpretation of religious freedom? This article seeks to answer these conceptual and substantive questions by comparing constitutional case law on religious freedom from India, Israel and the United States. It also provides linkages to ongoing processes of (alleged) constitutional retrogression in the three jurisdictions.
Assessing the African Union's 2016–19 Human Rights Action Planning Process: Embracing, and De-Coupling from, the Conventional “Ideal”
Authors: Okafor Obiora , Miyawa Maxwel , Bawa Sylvia , Odumosu-Ayanu Ibironke 
Published: July 2020

AbstractThis article assesses the African Union's planning process regarding the development of the African Human Rights Action Plan (AHRAP) against the dominant or conventional “ideal” or model of human rights action planning. It examines the extent to which the AU's process followed or departed from the conventional model, the strengths and weaknesses of the AU human rights action planning process, and the lessons scholars and policymakers have learned about more effective and more locally responsive human rights action planning. In doing so, the article sequentially addresses the following specific themes: human rights action planning as a concept and its essential elements; the key characteristics and features of the conventional “ideal” human rights action planning process; and the extent to which the AU plan conformed to or departed from this conventional process, and its import. It also teases out some key insights and lessons learnt (in terms of strengths and weaknesses) in respect of the AHRAP planning process.
The Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose (1886–1947): its formation, rise and demise
Authors: Bradley P J 
Published: July 2020

AbstractBackgroundThe Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose existed in Nottingham for over 60 years, but there is little knowledge or documentation regarding its existence.MethodsThe following resources were searched to find out more about the hospital: the Nottinghamshire Archives; Manuscripts and Special Collections at the University of Nottingham Libraries; and Nottingham Central Library. Information was also obtained from the founders’ relatives.ResultsThe hospital was founded in 1886, by Dr Donald Stewart, supported by political and clerical leaders. Initially, it treated out-patients only; in-patients were admitted for surgical treatment from 1905. Suitable accommodation was purchased in 1925, on Goldsmith Street, but required much building extension and alteration. Building restrictions during and following World War II prevented expansion. The National Hospital Survey conducted in 1945 considered the clinical work undertaken to be of a minor character, and recommended closure and amalgamation with the services provided by the Nottingham General Hospital. The hospital closed in 1947.ConclusionThe specialist hospital was deemed unfit and unsuitable to compete with the comprehensive service provided by the Nottingham General Hospital.
Engineering Value: The Transandine Railway and the ‘Techno-Capital’ State in Chile at the End of the Nineteenth Century
Authors: Harvey Kyle E. 
Published: July 2020

AbstractBy the end of the nineteenth century, railway expansion had led to the formation of a technocratic bureaucracy in Chile and other countries in Latin America. Central to this formation were the engineers who oversaw and regulated both public and private railways. Recently, historians have begun to re-examine engineers’ roles in this period. By employing methods and theoretical framings from the history of technology, this article argues that engineering was an important framework through which state–capital relations evolved, making engineers pivotal actors in the evolution of political economy at the time.