bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population
Authors: Lee Yun Jeong , Lee Cheol , Kim Mee Kum , Khwarg Sang In , Oh Joo Youn 
Published: December 2019

AbstractTo evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11.8%), subepithelial nevus (8.2%), and malignant melanoma (MM)(7.1%). Patients with compound nevus were younger than those with non-compound nevus (22.1 ± 17.0 vs 39.9 ± 18.8 years, p < 0.001), while patients with MM were older than those without melanoma (55.7 ± 18.2 vs 25.8 ± 18.0 years, p = 0.001). The lesion in compound nevus tended to be more frequently located on the temporal conjunctiva than that in the non-compound nevus group (54.4% vs 32.1%, p = 0.053), and feeder vessels were associated with most of compound nevus (98.2% vs 78.6% of non-compound nevus, p = 0.005). The lesion in MM was larger, involved multiple quadrants, and had extrabulbar location than lesions without melanoma (p < 0.001, p < 0.001, and p = 0.002, respectively). Together, the results would help clinicians to distinguish benign conjunctival pigmentations from malignant counterparts in clinical practice without biopsy.
Computational STAT3 activity inference reveals its roles in the pancreatic tumor microenvironment
Authors: Schaafsma Evelien , Yuan Yiwei , Zhao Yanding , Cheng Chao 
Published: December 2019

AbstractTranscription factor (TF) STAT3 contributes to pancreatic cancer progression through its regulatory roles in both tumor cells and the tumor microenvironment (TME). In this study, we performed a systematic analysis of all TFs in patient-derived gene expression datasets and confirmed STAT3 as a critical regulator in the pancreatic TME. Importantly, we developed a novel framework that is based on TF target gene expression to distinguish between environmental- and tumor-specific STAT3 activities in gene expression studies. Using this framework, our results novelly showed that compartment-specific STAT3 activities, but not STAT3 mRNA, have prognostications towards clinical values within pancreatic cancer datasets. In addition, high TME-derived STAT3 activity correlates with an immunosuppressive TME in pancreatic cancer, characterized by CD4 T cell and monocyte infiltration and high copy number variation burden. Where environmental-STAT3 seemed to play a dominant role at primary pancreatic sites, tumor-specific STAT3 seemed dominant at metastatic sites where its high activity persisted. In conclusion, by combining compartment-specific inference with other tumor characteristics, including copy number variation and immune-related gene expression, we demonstrate our method’s utility as a tool to generate novel hypotheses about TFs in tumor biology.
Palliativmedizinischer Versorgungsbedarf geriatrischer Patienten
Authors: Heusinger von Waldegg Gernot , Pfisterer Mathias 
Published: December 2019

Was ist neu?
Besondere Kompetenzen der Palliativmedizin Zu den besonderen Schwerpunkten der Palliativmedizin gehören die frühzeitige Erfassung von Behandlungsbedarfen und psychosozialen, spirituellen Bedürfnissen sowie die Kommunikation auch in ethischen Fragen.
Frühzeitige Identifizierung des palliativmedizinischen Behandlungsbedarfs In der stationären Versorgung müssen spezifische Instrumente zur Identifikation des palliativmedizinischen Versorgungsbedarfs geriatrischer Patienten weiter entwickelt werden.
Perspektiven für Qualifikation des Behandlungsteams, des geriatrischen Assessments und der palliativen Symptomlinderung Es stehen drei neue Leitlinien zur Verfügung: die erweiterte S3-Leitlinie Palliativmedizin für Patienten mit einer nicht heilbaren Krebserkrankung, die S3-Leitlinie Schmerzassessment bei alten Menschen in der vollstationären Altenhilfe und die S1-Leitlinie Geriatrisches Assessment der Stufe 2 für die palliativmedizinische Versorgung geriatrischer Patienten.
Palliativmedizinische Versorgung von Patienten mit Demenzerkrankungen Die Europäische Gesellschaft für Palliativmedizin hat ein Weißbuch mit Forderungen und Empfehlungen herausgegeben.
Durchbruchstörungen bleibender Zähne – Klinik
und Behandlungsmöglichkeiten
Authors: Dürwald Juliane , Köbel Chris , Dannhauer Karl-Heinz 
Published: December 2019

ZusammenfassungDas Wissen um den Mechanismus des Eruptionsvorgangs und die Ätiologie von
Durchbruchstörungen ist hilfreich bei deren Differenzialdiagnostik. So
erlaubt ein frühzeitiges Identifizieren von Malformationen
während der Gebissentwicklung das Einleiten für den Patienten
individuell abgestimmter Therapiestrategien.Ätiologie, Prävalenz, Ausprägung und Folgen,
diagnostische Maßnahmen, therapeutische Ansätze und
interdisziplinäre Zusammenarbeit bei Anomalien des Zahndurchbruchs der
zweiten Dentition werden in diesem Artikel beschrieben.
The Fetal Posterior Fossa on Prenatal Ultrasound Imaging: Normal Longitudinal Development and Posterior Fossa Anomalies
Authors: Pertl Barbara , Eder Sophie , Stern Christina , Verheyen Sarah 
Published: December 2019

AbstractFetal neurosonography and the assessment of the posterior fossa have gained in importance during the last 2 decades primarily due to the development of high-resolution ultrasound probes and the introduction of 3 D sonography. The anatomical development of the posterior fossa can be visualized well with the newest ultrasound technologies. This allows better knowledge of the anatomical structures and helps with understanding of the development of malformations of the posterior fossa. In this article the longitudinal development of the posterior fossa structures will be reviewed. The embryologic description will be compared with ultrasound descriptions. These embryologic and anatomic illustrations form the basis for the screening and diagnosis of malformations of the posterior fossa. During the first trimester, screening for open spina bifida as well as cystic malformations of the posterior fossa is possible. In the second and third trimester, malformations of the posterior fossa can be subdivided into 3 groups: fluid accumulation in the posterior fossa (Dandy-Walker malformation, Blake’s pouch cyst, mega cisterna magna, arachnoid cyst, vermian hypoplasia), decreased cerebellar biometrics (volume) (cerebellar hypoplasia, pontocerebellar hypoplasia) and suspicious cerebellar anatomy (Arnold-Chiari malformation, rhombencephalosynapsis, Joubert syndrome). This algorithm, in combination with knowledge of normal development, facilitates the diagnostic workup of malformations of the posterior fossa.
Automatisierte Berechnung und Visualisierung von Komorbiditätsindizes für den Tumorboard-Entscheid
Authors: Wald Theresa , Birnbaum Klemens , Wiegand Susanne , Dietz Andreas , Zebralla Veit , Wichmann Gunnar 
Published: December 2019

Zusammenfassung
Einleitung Komorbidität beeinflusst die für die kurative Therapie von Kopf-Hals-Karzinomen (HNC) verfügbaren Optionen. Das manuelle Zusammentragen der Nebenerkrankungen vor der Anmeldung im interdisziplinären Tumorboard (TB) ist zeitintensiv und oft unvollständig. Eine automatisierte Erfassung von nach ICD-10 kodierten Komorbiditätsdaten und deren Darstellung könnte die therapeutische Entscheidungsfindung im TB verbessern sowie bestehenden Informationsbedarf aufzeigen.
Material und Methoden Die ICD-10-Codes unserer Patienten wurden aus 4 Datenbanken (hospital-information-system (HIS*-MED), der klinikinternen Tumordatenbank, OncoFlow® und OncoFunction®) extrahiert. Nach der Datensatzverknüpfung mittels der Python-Programmbibliotheken Pandas und Record Linkage wurden die ICD-10-Codes bezüglich des Charlson-Scores gewichtet und für die Implementierung in OncoFlow visualisiert. Die Kodierqualität wurde am Beispiel Diabetes an einer 1:1 gematchten Stichprobe von 240 Patienten überprüft.
Ergebnisse 29 073 ICD-10-Codes von 2087 Patienten mit HNC wurden extrahiert. Die Anmeldung eines Patienten im TB triggert die sofortige automatische Erfassung und Visualisierung der Daten als Piktogramm in OncoFlow. Dies ermöglicht die schnelle Erfassung und Bewertung der Komorbidität sowie erforderlicher Diagnostik zur Komplettierung der Daten. Die klinikinterne Validationsstudie ergab eine Präzision der durch Datenimport verfügbaren Information zu Diabetes von 95,0 %.
Diskussion Patienten mit HNC weisen häufig für die Therapieentscheidung relevante Nebenerkrankungen auf. Die automatisierte Erfassung der Komorbidität aus administrativen Daten und deren intuitive Darstellung ist ressourcen- und kostengünstig möglich. Voraussetzung ist eine präzise, vollständige Verschlüsselung der Krankheitsdiagnosen.
Fabrication and Characterization of Chitosan-Collagen Membrane from Barramundi (Lates Calcarifer) Scales for Guided Tissue Regeneration
Authors: Susanto Agus , Satari Mieke Hemiawati , Abbas Basril , Koesoemowidodo R. Setyo Adji , Cahyanto Arief 
Published: December 2019

Abstract
Objectives The aim of this study was to evaluate the synthesis, mechanical strength, and morphology of chitosan–collagen membranes from barramundi scales for guided tissue regeneration technique.
Materials and Methods Collagen was extracted from barramundi scales by immersion in acetic acid. The resulting wet collagen was later dried. The membrane was fabricated by mixing chitosan with collagen from barramundi scales. Membrane characterization parameters were measured using Fourier transform infrared (FTIR), scanning electron microscopy (SEM) and mechanical property.
Results The FTIR spectrum showed the typical peak of the mixture of chitosan and collagen. The tensile strength and elongation at break of the membrane in dry condition were 0.28 MPa and 8.53%, respectively, while in the wet condition these were 0.12 MPa and 25.6%. The membrane porosity test result was 38.85%; SEM result showed a porous membrane surface with size varying around 16 to 100 µm.
Conclusion The chitosan-collagen membrane from the barramundi scale showed the fibrous membrane surface that has ideal porous size as guided tissue regeneration membrane and the lower mechanical strength.
Transtemporal Ultrasound (US) Assessment of Third Ventricle Diameter (TVD): Comparison of US and MRI TVD in Pediatric Patients
Authors: Kerscher Susanne R. , Schweizer Louise L. , Nägele Thomas , Bevot Andrea , Alber Michael , Schuhmann Martin U. 
Published: December 2019

Abstract
Introduction In a retrospective magnetic resonance imaging (MRI)-based study, we showed that changes of the third ventricle diameter (TVD) are a reliable mirror of changes of the entire ventricular system. The third ventricle is easily accessible in more than 90% of children and adults using ultrasound (US) via the transtemporal bone-window; thus it can be assessed quickly and free of radiation. In order to use transtemporal US determination of TVD instead of MRI/CT in clinical practice, it is important to know if there is a correlation and bias between both methods, which is addressed in this study.
Materials and Method This prospective study investigates 122 children (newborn–18 years). Diagnoses encompassed hydrocephalus (50%), tumors (14.8%), and other intracranial pathologies (35.2%). US-based TVD was measured via the transtemporal bone-window using a phased array 1 to 4MHz transducer. Results were compared with TVD measured on simultaneously acquired axial T1-weighted axial MRI or computed tomography (CT) scans.
Results Overall mean values for TVD were 6.56 ± 5.84 and 6.47 ± 5.64 mm for US and MRI, respectively. There was an outstanding correlation between TVD measured by MRI and US (r = 0.991, p < 0.01). Bland–Altman analysis showed a mean bias of 0.096 mm with limits of agreement of –0.99 and 1.18 mm.
Conclusion US- and MRI-based TVD measurements correlate excellently and measure almost identical TVD values. US-based TVD is in mean ∼0.096 mm larger than MRI-based TVD due to a more angulated measurement plane. US is equal to the gold-standard MRI, a fact, opening new avenues for US-based TVD as a first-line assessment tool of ventricular width.
The trilemma of sustainable industrial growth: evidence from a piloting OECD’s Green city
Authors: Vuong Quan-Hoang , Ho Manh-Tung , Nguyen Hong-Kong To , Nguyen Minh-Hoang 
Published: December 2019

AbstractCan green growth policies help protect the environment while keeping the industry growing and infrastructure expanding? The City of Kitakyushu, Japan has actively implemented eco-friendly policies since 1967 and recently inspired the pursuit of sustainable development around the world, especially in the Global South region. However, empirical studies on the effects of green growth policies are still lacking. This study explores the relationship between road infrastructure development and average industrial firm size with air pollution in the city through the Environmental Kuznets Curve (EKC) hypothesis. Auto-Regressive Distributed Lag (ARDL) and Non-linear Auto-Regressive Distributed Lag (NARDL) methods were applied on nearly 50-years’ time series data, from 1967 to 2015. The results show that the shape of the EKC of industrial growth, measured by average firm size, depends on the type of air pollution: inverted N-shaped relationships with NO2 and CO, and the U-shaped relationships with falling dust particle and Ox. Regarding infrastructure development, on the one hand, our analysis shows a positive effect of road construction on alleviating the amount of falling dust and CO concentration. On the other hand, the emissions of NO2 and Ox are shown to rise when plotted against road construction. The decline of CO emission, when plotted against both industrial growth and road development, indicates that the ruthlessness of the local government in pursuing green growth policies has been effective in this case. However, the story is not straightforward when it comes to other air pollutants, which hints at the limits of the current policies. The case of Kitakyushu illustrates the complex dynamics of the interaction among policy, industry, infrastructure, and air pollution. It can serve as an important reference point for other cities in the Global South when policies are formed, and progress is measured in the pursuit of a green economy. Finally, as an OECD SDGs pilot city and the leading Asian green-growth city, policymakers in Kitakyushu city are recommended to revise the data policy to enhance the findability and interoperability of data, as well as to invest in the application of big data.
Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis
Authors: Zang Weicheng , Yang Chuanzhen , Li Tingting , Liao Liming , Zheng Xiaofeng 
Published: December 2019

SignificanceThe TLS pathway plays a vital role in maintaining genome integrity during DNA replication. Here we describe a previously unknown TLS regulatory mechanism mediated by HSCARG, a cellular redox sensor. HSCARG enhances the interaction between PCNA and USP1 and thus inhibits PCNA ubiquitination, which further impairs the recruitment of POLH and promotes the generation of DSBs. Consequently, the up-regulation of HSCARG exacerbates mammary tumorigenesis. Importantly, the cellular redox state regulates HSCARG dimerization and subcellular localization and influences the efficiency of HSCARG in regulating the TLS pathway. Our studies discover a regulator of the TLS pathway and identify a crosstalk between the cellular redox status and the DNA damage response.
Optimizing photoswitchable MEK
Authors: Patel Aleena L. , Yeung Eyan , McGuire Sarah E. , Wu Andrew Y. , Toettcher Jared E. , Burdine Rebecca D. , Shvartsman Stanislav Y. 
Published: December 2019

SignificanceControlling access to the active sites of kinases using photo-dimerizable domains revolutionizes the types of possible optogenetic perturbations of cell signaling. This technology, however, is useful only when there is strong kinase activity to harness. We report a strategy to systematically enhance and tune functionality of a kinase activating the Extracellular Signal-Regulated Kinase (ERK) pathway, MEK, using gain-of-function point mutations that destabilize MEK. Photoswitching mutant MEK activity by reversibly caging its active site controls a large dynamic range of ERK signaling in vivo. Our approach for optimizing and tuning light-activated protein kinases is not limited to MEK and can be used to systematically extend the capabilities of light-activated regulatory enzymes.
Developing and validating involvement in translation scale and its relationship with translation
ability
Authors: Modarresi Ghasem 
Published: December 2019

Abstract
The concept of involvement has not been touched by professionals in Translation Studies. The present study aimed
to develop and validate a scale of involvement in translation and to examine its relationship with students’ translation ability.
In so doing, altogether, a pool of 20 translation teachers and 120 translation students participated in the study. Initially, the
researcher tried to elicit the most commonalities from translation teachers regarding students’ involvement in translation. Then,
the reliability and validity of the designed scale were determined by means of Cronbach’ Alpha, Factor Analysis and Structural
Equation Modeling. The validated scale was named Involvement in Translation Scale, including four underlying constructs. Finally,
the results confirmed that there was a large, positive correlation between students’ scores on involvement in translation and
their translation ability [r = .72, n = 40, p < .05]. Translation students
are suggested to focus on those aspects of their translation that foster their immersion in translation practice.
On the translatability of Qur’anic pun
Authors: Al-Kharabsheh Aladdin , Houji Khalid 
Published: December 2019

AbstractThis paper explores the translatability of Qur’anic pun. With reference to a phalanx of authoritative Qur’anic exegetes and three leading Qur’anic translations, and by drawing onʿAtīq’s (1985)taxonomy of Arabic pun, andDelabastita’s (2004)model of pun translation, the study examines a four-fold classification of pun: (1)abstract pun, (2)immediate-meaning-oriented pun, (3)far-meaning-oriented pun, and (4)aided pun. Given the semantic indirectness and sophistication immanent in punning, it is argued that Qur’anic pun, as a rhetorical device, is quite thorny from a translational standpoint. The study reveals that three out of nine translation strategies have been used: theliteral strategy, themanipulative strategy, and thesituational strategy. Theliteral strategycapitalizes on the immediate meaning, and ‘auctions off’ or ‘pulverizes’ the punning meaning, which, subsequently, may result inincommensurate translation damage. Thesituational strategyinvolves adding,for the entire translation, a descriptive word or phrase between brackets, and themanipulative strategyadvocatestext-in-contextperspective. The study wraps up with a proposal for theinterpretive strategy, which hinges uponexegesis-driven paraphrasing. This particular translation strategy has a greater emancipatory potential.
A study of Macao tertiary students’ attitudes to issues in postcolonial Macao’s language policy and
planning
Authors: Yan Xi 
Published: December 2019

Abstract
This study focuses on Macao, a former Portuguese colony and a Special Administrative Region of the People’s
Republic of China after 1999. A questionnaire survey and semi-structured interviews were conducted in 2012 and 2013 respectively
among freshmen of the University of Macau to investigate their attitudes to issues in Macao’s language policy and planning (LPP).
Findings of this study reflect their practical attitudes, as reflected in their attitudes towards the choice of English or
Portuguese as the first foreign language in Macao public schools. At the same time, their attitudes also reflect their strong
local allegiances and resistance to Mainland China’s cultural practices, as reflected in their views on the issue of the official
status of Putonghua in the Macao SAR, the choice of Putonghua or Cantonese as the medium of instruction, and the maintenance of
traditional Chinese characters, written Cantonese, and Cantonese Romanization System in Macao.
Aluminium recovery from water treatment sludge under different dosage of sulphuric acid
Authors: Hassan Basri M H , Mohammad Don N N , Kasmuri N , Hamzah N , Alias S , Azizan F A 
Published: December 2019

Abstract
Aluminium sulphate Al2(SO4)3 known as alum is commonly added chemical in coagulation-flocculation process in water treatment plants. Despite of its effectiveness in treating the water, it produces high volume of residual alum sludge to be discarded to sludge lagoon. Therefore, sludge disposal is one of the main drawbacks in water treatment plants as it requires large footprints to store the residual sludge before being dumped at landfills. The sludge still contains high concentrations of aluminium that can be recovered for further use. Acidification process using sulphuric acid is investigated in this study to recover the aluminium from sludge. Different dosage of sulphuric acid ranges at 0.45 – 1.80M at constant weight of alum sludge at 300g were analysed to obtain the maximum percentages of aluminium recovery. Inductively coupled plasma optical emission spectrometry (ICP-OES) was used to analyse the recovered aluminium concentration. Besides the element of aluminium, other elements such as Ferum (Fe), Calcium (Ca) and Potassium (K) were also recovered through the acidification process. It was found that element of aluminium shows the highest concentration. The optimum recovery of aluminium was attained at alum sludge 300g and dosage of 1.35M sulphuric acid in which the recovery ratio at up to 98%. This shows that the aluminium present at high concentration in the sludge and if the sludge is dumped at landfills, the remaining aluminium will affect the environment. Furthermore, it is recommended that the recovered aluminium from water treatment sludge has the potential to be an alternative coagulant element in water treatment process.
Corrugated bamboo roofing design of microwave absorber for reflection absorption
Authors: Mohamat Kasim N , Abdullah@Idris H , Ali Mokhtar M F A B , Ahmad A , Mohamad Noor N , Mohd Kasim L , Ismail N A , Mohd Faudzi N , Taib M N 
Published: December 2019

Abstract
Nowadays, the resources of roofing materials are abundant, which are the essential materials to build houses. It is of great significance to develop the roofing material with absorbing function for shielding electromagnetic radiation. This study is conducted to design a corrugated bamboo roofing microwave absorber that can absorb electromagnetic wave for frequencies 1 to 12 GHz. Three types of roofing bamboo with different designs namely Model A, Model B and Model C has been developed. The size of all types of proposed roofing bamboo is 60 cm width x 60 cm in length. The design is simulated using Computer Simulation Technology (CST) Microwave Studio software. The arch method is used to analyse microwave absorber performance. It contains of a wooden structure in the shape of semi-circular for enabling the proper positioning towards transmitting and receiving the two horn antennas. Bamboo can be used as an absorbent material. The expected result for bamboo roofing microwave absorber is to get a high performance of microwave absorption which is above 20 dB. The third model or Model C has recorded the highest value of an absorption level.