bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasmonic biosensors fabricated by galvanic displacement reactions for monitoring biomolecular interactions in real time
Authors: Pacholski Claudia , Rosencrantz Sophia , Rosencrantz Ruben R. , Balderas-Valadez Ruth Fabiola 
Published: January 2020

AbstractOptical sensors are prepared by reduction of gold ions using freshly etched hydride-terminated porous silicon, and their ability to specifically detect binding between protein A/rabbit IgG and asialofetuin/Erythrina cristagalli lectin is studied. The fabrication process is simple, fast, and reproducible, and does not require complicated lab equipment. The resulting nanostructured gold layer on silicon shows an optical response in the visible range based on the excitation of localized surface plasmon resonance. Variations in the refractive index of the surrounding medium result in a color change of the sensor which can be observed by the naked eye. By monitoring the spectral position of the localized surface plasmon resonance using reflectance spectroscopy, a bulk sensitivity of 296 nm ± 3 nm/RIU is determined. Furthermore, selectivity to target analytes is conferred to the sensor through functionalization of its surface with appropriate capture probes. For this purpose, biomolecules are deposited either by physical adsorption or by covalent coupling. Both strategies are successfully tested, i.e., the optical response of the sensor is dependent on the concentration of respective target analyte in the solution facilitating the determination of equilibrium dissociation constants for protein A/rabbit IgG as well as asialofetuin/Erythrina cristagalli lectin which are in accordance with reported values in literature. These results demonstrate the potential of the developed optical sensor for cost-efficient biosensor applications.
Surgical Complications in Children with CDH: A Multivariate Analysis
Authors: Heiwegen Kim , van Rooij Iris A. L. M. , van Heijst Arno , de Blaauw Ivo , Botden Sanne M. B. I. 
Published: January 2020

AbstractIntroductionSeveral medical and surgical improvements in the treatment of congenital diaphragmatic hernia (CDH) patients have led to a higher survival rate. However, some of these improvements also lead to an increased morbidity rate. This study aims to determine the contribution different medical and surgical treatments have had on the development of surgical complications.MethodAll CDH patients treated in a single centre between 2000 and 2015 were retrospectively evaluated. Multivariate logistic regression was used to estimate the independent effects of several treatment options that could influence the surgical outcome by adjustment for multiple risk factors.ResultsSixty of the 197 surgically repaired CDH patients had surgical complications. There were more haemorrhagic complications in the ECMO compared to non‐ECMO group (27% vs. 2%, p < 0.001). The use of inhaled nitric oxide was also significantly related to haemorrhage (OR = 13.0 (95% CI 1.1–159)). After adjustment for other risk factors, chylothorax was neither significantly associated with ECMO treatment (OR = 1.6 (95% CI 0.5–5.2) nor with patch repair (OR = 2.1: 95% CI 0.7–6.1). A recurrence occurred more often in patients with pulmonary hypertension (OR = 10.0 (95% CI 1.5–65.8) and after treatment with an abdominal patch (OR = 11.3: 95% CI 1.5–84.4).ConclusionECMO treatment and the inhalation of nitric oxide are used in the most severe CDH patients but are associated with a higher risk on surgical haemorrhage. The recurrence rate is associated with both the use of an abdominal patch and the presence of pulmonary hypertension, regardless of medical treatment.
Standardised Suffixes in the Nomenclature of the Higher Taxa of Prokaryotes an Aid to Data Mining, Database Administration and Automatic Assignment of Names to Taxonomic Ranks
Authors: Tindall B. J. 
Published: January 2020

AbstractThe formation and use of the scientific names of prokaryotes is governed by the International Code of Nomenclature of Prokaryotes. Originally deriving from the 1935 revision of the International Code of Botanical Nomenclature, it retains the treatment of scientific names as Latin words. Above the rank of genus the rank is generally denoted by a single, standardised suffix. This has great advantage in text mining and database infrastructure where the identification of the standardised suffix can automatically be linked to the rank at which the scientific name is being used. The only exception at present are names at the rank of class where, although a standardised suffix has been proposed (-ia) it does not allow one to unambiguously identify the rank of the scientific name, since it is also a suffix used at the rank of genus. In addition, due to the fact that the suffix at the rank of class was not regulated in earlier versions of the International Code of Nomenclature of Bacteria, there are names that do not follow the standardised suffix. Uniformity would be an advantage. The problem and a proposed solution are discussed.
Contrasting regional and global climate simulations over South Asia
Authors: Rana Arun , Nikulin Grigory , Kjellström Erik , Strandberg Gustav , Kupiainen Marco , Hansson Ulf , Kolax Michael 
Published: January 2020

AbstractTwo ensembles of climate simulations, one global and one regional, are used to investigate model errors and projected climate change in seasonal mean temperature and precipitation over South Asia. The global ensemble includes ten global climate models (GCMs). In the regional ensemble all ten GCMs are downscaled by a regional climate model—RCA4 over South Asia at 50 km resolution. Our focus is on the Indian Summer Monsoon season (June–August) and we show that RCA4 can reproduce, reduce or amplify large-scale GCM biases depending on regions and GCMs. However, the RCA4 bias pattern in precipitation is similar across the simulations, regardless of forcing GCM, indicating a strong RCA4 imprint on the simulated precipitation. For climate change, the results indicate, that RCA4 can change the signal projected by the GCM ensemble and its individual members. There are a few RCA4 simulations with a substantial reduction of projected warming by RCA4 compared to the driving GCMs and with a large regional increase in precipitation absent in the GCMs. We also found that in a number of subregions warm RCA4 biases are related to stronger warming and vice versa, while there is no such dependency in the GCM ensemble. Neither the GCM nor the RCA4 ensemble shows any significant dependency between projected changes and biases for precipitation. Our results implicate that using only RCMs and excluding GCMs, a commonly established approach, can significantly change the message on future regional climate change.
Efficacy and safety of galcanezumab for preventive treatment of migraine: a systematic review and meta-analysis
Authors: Zhao Xiuyuan , Xu Xiaolin , Li Qingyun 
Published: January 2020

Abstract
Objective
This meta-analysis aimed to systematically evaluate the effectiveness and safety of galcanezumab in the prophylactic treatment of adult migraine.

Methods
A systematic literature search was performed to identity randomized-controlled trials (RCTs). The primary outcome was the decline in the number of monthly migraine days (MMDs). Secondary outcomes included the reduction of monthly acute migraine‑specific medication days (MSMDs), the number of participants showing a reduction in MMDs from baseline of ≥ 50%, ≥ 75%, and 100%, the incidence of adverse events (AEs), and the number of participants developing anti-drug antibodies (ADAs) to galcanezumab. We calculated the mean difference (MD), relative risk (RR), and 95% confidence intervals (CIs) for these outcomes.

Results
Among the five included trials, galcanezumab given at doses of 120, 150, 240, and 300 mg was superior to placebo for both MMDs and secondary outcomes. The degree of AEs in all group was mild. Notably, no significant differences were found in the occurrence of AEs and ADAs between the galcanezumab and placebo groups.

Conclusion
Galcanezumab is a safe and effective treatment for adult patients with episodic and chronic migraine.
Gender comparison of clinical, histopathological, therapeutic and outcome factors in 185,967 colon cancer patients
Authors: Schmuck Rosa , Gerken Michael , Teegen Eva-Maria , Krebs Isabell , Klinkhammer-Schalke Monika , Aigner Felix , Pratschke Johann , Rau Beate , Benz Stefan 
Published: January 2020

Abstract
Introduction
Colorectal carcinomas represent the third most common cause of cancer-related deaths in Germany. Although the incidence is significantly higher in men compared with women and gender is a well-established crucial factor for outcome in other diseases, detailed gender comparisons for colon cancer are lacking.

Methods
This retrospective population-based cohort study included all patients diagnosed with colon cancer in Germany between 2000 and 2016 who were included in the common dataset of colorectal cancer patients from the quality conference of the German Cancer Society. We compared clinical, histopathological, and therapeutic characteristics as well as overall and recurrence-free survival.

Results
A total of 185,967 patients were included in the study, of which 85,685 were female (46.1%) and 100,282 were male (53.9%). The proportion of women diagnosed with colon cancer decreased from 2000 to 2016 (f: 26.6 to 40.1%; m: 24.9 to 41.9%; p < 0.001), and the proportion of very old patients was especially high in women (f: 27.3%; m: 15.6%; p < 0.001). The localization in women was more right-sided (f: 45.0%, m: 36.7%; p < 0.001), and women had a higher tumor grading and a higher UICC stage (especially stage III nodal-positive) at diagnosis of primary colon cancer (UICC III: f: 22.7%, m: 21.0%; p < 0.001). We could detect a significantly better overall (hazard ratio: 0.853, lower 95%: 0.841, upper 95%: 0.864; p < 0.001) and recurrence-free survival (hazard ratio: 0.857, lower 95%: 0.845, upper 95%: 0.868; p < 0.001) in women compared with men, even though women received chemotherapy less frequently compared with men (f: 26.1%, m: 28.1%; p < 0.001).

Conclusion
We could detect several variables that differed significantly between men and women regarding clinical, histopathological, therapeutic, and outcome factors. We believe that it is crucial to consider gender as a key factor in the diagnosis and treatment of colon cancer. Sex-specific diagnostic tools could lead to an earlier diagnosis of colon cancer in women, and ways to increase the rate of chemotherapy in women should be evaluated. Furthermore, we recommend stratifying randomized trials by gender.
Untangling the Gordian knot—further resolving the super-species complex of 300-million-year-old xiphosurids by reconstructing their ontogeny
Authors: Haug Carolin , Haug Joachim T. 
Published: January 2020

AbstractThe group Xiphosurida (horseshoe “crabs”) is today only represented by four species. However, in the fossil record, several dozen species have been described, especially from the Carboniferous (about 300 million years ago). Several species have been interpreted as representatives ofEuproopsorBelinurus, but there is ongoing discussion which of these species are valid and how they can be differentiated. Recent studies suggested that differences in the timing of individual development could provide information for species distinction, exemplified by studies onEuproops danae(Mazon Creek, USA) andEuproopssp. (“Piesproops”; Piesberg, Germany). For this study, we reinvestigated all Carboniferous xiphosurids from the British Coal Measures stored in the collections of the Natural History Museum London. Size comparisons of the specimens revealed nine size groups; the smaller specimens were originally labelled asBelinurus, the larger ones asEuproops. The nine size groups exhibit five different morphotypes differing in structures surrounding the posterior shield (= thoracetron): spines of different lengths and, in larger specimens, a more or less developed flange. Two of these morphotypes show significantly longer spines than the remaining specimens and could be conspecific asE. anthrax. The remaining specimens are interpreted as growth series of another species, presumably ofE. rotundatus. An ontogenetic flange formation is also known fromE. danaeand the “Piesproops”, but the timing differs between all three species. InE. rotundatus, the flange develops rather late, but then comparably abruptly, which makes this development more metamorphic in relation to development in the other species.
Nephila edulis—breeding and care under laboratory conditions
Authors: Liebsch C. , Fliess M. , Kuhbier J. W. , Vogt P. M. , Strauss S. 
Published: January 2020

AbstractDue to fascinating mechanical and biological characteristics spider silk is of great interest in many research fields. Among the orb-weavers Nephila edulis is one of the species used as source for natural spider silk in laboratories. Under appropriate conditions, animals can be kept and bred easily. This manuscript gives information about the spiders’ natural habitat, behavior, and breeding and compares them with the established methods and conditions within a research laboratory. Keeping conditions and methods of rearing are described in detail. Within a keeping facility with reliable supply of food, cannibalism rate is significantly reduced and spiders mate all year long. Cohabitants of the genus Steatoda are routinely found in laboratory keeping. While these small spiders do not pose a threat to Nephila edulis, cellar spiders (family Pholcidae) have to be extracted as they have been observed hunting for Nephila spiders.
Urban green infrastructure as a tool for controlling the resilience of urban sprawl
Authors: Vargas-Hernández José G. , Zdunek-Wielgołaska Justyna 
Published: January 2020

AbstractThis paper is aimed to analyze the existing relationships and controlling functions between the urban green infrastructures on the resilience of the urban sprawl. The analysis begins questioning whether urban sprawl sustainable growth can be controlled after achieving urban supported by urban green infrastructure. The analytic method used is based on developing a conceptual and theoretical framework of reference to review the literature on the main variables of the research: Green infrastructure, resilience, and urban sprawl. It is concluded that while it is difficult to find linear causality in a direct relationship among the variables of the analysis, it is supported by the existence of more holistic connectivity leading to the controlling of the urban sprawl. The analysis suggests that a holistic approach is required to build urban resilience based on green infrastructure by addressing a fuller range of ecosystem disturbances and disasters, to create the outcomes that develop the environmental and ecological benefits of urban spectrum of ecosystem disturbances and disasters, to create the outcomes that develop the environmental and ecological benefits of urban sprawl.
Maternal practices and perceptions of child body mass status explain child energy expenditure behaviors and body mass
Authors: Boberska Monika , Zarychta Karolina , Knoll Nina , Keller Jan , Hohl Diana Hilda , Horodyska Karolina , Kruk Magdalena , Luszczynska Aleksandra 
Published: January 2020

AbstractThis study investigated whether maternal perceptions of child body mass status would predict child body mass index (BMI) z-score via two sets of sequential mediators: (1) four maternal practices promoting child energy expenditure and (2) children’s energy expenditure behaviors. The data ofN = 729 mother–child dyads were collected at baseline [T1;n = 495 at 7- to 8-month follow-up (T2)]. Mothers reported perceptions of child body mass status and maternal practices (T1); children reported sedentary screen use and physical activity (T1, T2). Child body mass was assessed objectively (T1, T2). Higher stimulation to be active (T1) was related to a lower child BMI z-score (T2) via higher levels of child physical activity (T2). Higher levels of monitoring of screen use (T1) were associated with higher child BMI z-score (T2) via lower levels of child physical activity (T2). Encouraging parents to stimulate their children to be active may be beneficial for children’s weight maintenance.
Cytogenetics of Fraxinus mandshurica and F. quadrangulata: ploidy determination and rDNA analysis
Authors: Islam-Faridi Nurul , Mason Mary E. , Koch Jennifer L. , Nelson C. Dana 
Published: January 2020

AbstractAshes (Fraxinus spp.) are important hardwood tree species in rural, suburban, and urban forests of the eastern USA. Unfortunately, emerald ash borer (EAB,Agrilus planipennis) an invasive insect pest that was accidentally imported from Asia in the late 1980s–early 1990s is destroying them at an alarming rate. All North American ashes are highly susceptible to EAB, although blue ash (F. quadrangulata) may have some inherent attributes that provide it some protection. In contrast Manchurian ash (F. mandshurica) is relatively resistant to EAB having coevolved with the insect pest in its native range in Asia. Given its level of resistance, Manchurian ash has been considered for use in interspecies breeding programs designed to transfer resistance to susceptible North American ash species. One prerequisite for successful interspecies breeding is consistency in chromosome ploidy level and number between the candidate species. In the current study, we cytologically determined that both Manchurian ash and blue ash are diploids (2n) and have the same number of chromosomes (2n = 2x = 46). We also characterized these species’ ribosomal gene families (45S and 5S rDNA) using fluorescence in situ hybridization (FISH). Both Manchurian and blue ash showed two 45S rDNA and one 5S rDNA sites, but blue ash appears to have an additional site of 45S rDNA. The 5S rDNA in both species is colocalized interstitially with one of the 45S rDNA sites. The copy number of these two ribosomal gene families in Manchurian ash were observed to be quite varied, which indicates the species are still undergoing evolutionary homogenization.
SEOM clinical guideline thyroid cancer (2019)
Authors: Gallardo E. , Medina J. , Sánchez J. C. , Viúdez A. , Grande E. , Porras I. , Ramón y Cajal T. , Trigo J. , Iglesias L. , Capdevila J. 
Published: January 2020

AbstractThyroid carcinoma is the most frequent endocrine malignancy and accounts for around 3% of global cancer incidence. Different histologies and clinical scenarios make necessary a multidisciplinary approach that includes new diagnostic methods and surgical, radiopharmaceutical and systemic therapies. This guideline updates several aspects of management of thyroid cancer.
Psychometric properties and measurement invariance of the Polish version of the dyadic coping inventory
Authors: Wendołowska Anna M. , Czyżowska Dorota , Bodenmann Guy 
Published: January 2020

AbstractRecently, there has been growing interest in stress and coping strategies from a relational perspective. Researchers recognize the importance of a partner’s coping strategy in terms of relationship satisfaction and a relational sense of well-being. The aim of the article is to present the results of work on the Polish validation of the Dyadic Coping Inventory (DCI), which was developed by Bodenmann et al. (2008). Dyadic coping is a multidimensional construct which consists of stress communication by partners and four components of dyadic coping behavior: supporting, delegated, negative and common behavior. The DCI examines the quality of communication between partners and the level of dyadic coping with stress. The DCI was tested based on a study of 550 people (275 couples) aged between 20 and 72. The conducted analyses were aimed at checking the factor structure and psychometric properties of the Polish version of the DCI. Measurement invariance (MI) was also tested across genders on a Polish sample and across cultures on Polish, Swiss and Romanian samples. After rejection of three pairs of items, factor analysis of the DCI revealed a 5-factor structure with respect to a partner’s own dyadic coping and their partner’s dyadic coping and a 2-factor structure with respect to common dyadic coping. MI results confirmed the criteria for configural, metric and full scalar invariance across genders and configural, metric and partial scalar invariance across cultures. The Polish version of DCI has satisfactory psychometric characteristics and can be used to assess the dyadic coping of people in romantic relationships; also, it can be used in cross-cultural studies.
GridTables: A One-Size-Fits-Most H2TAP Data Store
Authors: Pinnecke Marcus , Campero Durand Gabriel , Broneske David , Zoun Roman , Saake Gunter 
Published: January 2020

AbstractHeterogeneous HybridTransactionalAnalytical Processing ($$\mathrm{H}^{2}$$H2TAP) database systems have been developed to match the requirements for low latency analysis of real-time operational data. Due to technical challenges, these systems are hard to architect, non-trivial to engineer, and complex to administrate. Current research has proposed excellent solutions to many of those challenges in isolation – a unified engine enabling to optimize performance by combining these solutions is still missing. In this concept paper, we suggest a highly flexible and adaptive data structure (called gridtable) to physically organize sparse but structured records in the context of $$\mathrm{H}^{2}$$H2TAP. For this, we focus on the design of an efficient highly-flexible storage layout that is built from scratch for mixed query workloads. The key challenges we address are: (1) partial storage in different memory locations, and (2) the ability to optimize for mixed OLTP-/OLAP access patterns. To guarantee safe and well-specified data definition or manipulation, as well as fast querying with no compromises on performance, we propose two dedicated access paths to the storage.In this paper, we explore the architecture and internals of gridtables showing design goals, concepts and trade-offs. We close this paper with open research questions and challenges that must be addressed in order to take advantage of the flexibility of our solution.
Nanoformulations as a modern form of biofungicide
Authors: Miastkowska Małgorzata , Michalczyk Alicja , Figacz Katarzyna , Sikora Elżbieta 
Published: January 2020

Abstract
Purpose
The aim of this study was to elaborate new forms of biofungicide formulations which could increase biological activity of essential oil against various strains of pathogenic fungi of plants, dermatophytes, and molds.

Methods
The nanoemulsions containing four various essential oils (cinnamon, thyme, manuka, and tea tree oil) were obtained by using the low-energy (PIC) and the high-energy emulsification methods (ultrasonification). The physicochemical properties and activity of prepared systems against strains of pathogenic fungi of plants (F. culmorum, Ph. cactorum), dermatophytes (T. mentagrophytes M. gypseum) and molds (S. brevicaulis, A. niger) were examined. Fungicidal activity was tested by the method of linear growth of mycelium on an agar medium. Macroemulsions containing the oils and the pure essential oils were used as comparative samples.

Results
It was found that nanoemulsions prepared by ultrasonification showed excellent fungicidal activity compared to pure oils and macroemulsions. Among others, the manuka oil nanoformulations showed the highest activity against the tested fungi.

Conclusions
Nanoemulsions can be applied as the effective carriers of essential oils. They allow the reduction of the concentration of the bioactive oils while maintaining biological activity. The obtained nanosystems can be applied as safe, biodegradable, eco-friendly antifungal products in pharmaceutical, cosmetic, and agrochemical industries as they increase the biological activity of the tested oils against various type of fungi.