bluuebunny/crossref_metadata_2025_split huggingface dataset:
Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination
Authors: Kato Yu , Steiner Thiago M. , Park Hae-Young , Hitchcock Rohan O. , Zaid Ali , Hor Jyh Liang , Devi Sapna , Davey Gayle M. , Vremec David , Tullett Kirsteen M. , Tan Peck S. , Ahmet Fatma , Mueller Scott N. , Alonso Sylvie , Tarlinton David M. , Ploegh Hidde L. , Kaisho Tsuneyasu , Beattie Lynette , Manton Jonathan H. , Fernandez-Ruiz Daniel , Shortman Ken , Lahoud Mireille H. , Heath William R. , Caminschi Irina 
Published: August 2020

Abstract
Follicular dendritic cells and macrophages have been strongly implicated in presentation of native Ag to B cells. This property has also occasionally been attributed to conventional dendritic cells (cDC) but is generally masked by their essential role in T cell priming. cDC can be divided into two main subsets, cDC1 and cDC2, with recent evidence suggesting that cDC2 are primarily responsible for initiating B cell and T follicular helper responses. This conclusion is, however, at odds with evidence that targeting Ag to Clec9A (DNGR1), expressed by cDC1, induces strong humoral responses. In this study, we reveal that murine cDC1 interact extensively with B cells at the border of B cell follicles and, when Ag is targeted to Clec9A, can display native Ag for B cell activation. This leads to efficient induction of humoral immunity. Our findings indicate that surface display of native Ag on cDC with access to both T and B cells is key to efficient humoral vaccination.
Maternal- and Fetal-Encoded Perforin-2 Limits Placental Infection by a Bloodborne Pathogen
Authors: Gayle Petoria , McGaughey Vanessa , Hernandez Rosmely , Wylie Marina , Colletti Rachel C. , Nguyen Ka Lam , Arons Marshall , Padula Laura , Strbo Natasa , Schesser Kurt 
Published: August 2020

Abstract
Placental immune responses are highly regulated to strike a balance between protection and tolerance. For relatively mild infections, protection encompasses both the mother and fetus; however, during worsening conditions, protection becomes exclusively reserved for the mother. Previously, we and others have shown that the host factor perforin-2 plays a central role in protecting mice and cells against infection. In this study, we analyzed perforin-2 activity in the mouse placenta to determine whether perforin-2 plays a similarly protective role. We show that perforin-2 is critical for inhibiting Listeria monocytogenes colonization of the placenta and fetus and that this protection is due to both maternal and fetal-encoded perforin-2. Perforin-2 mRNA is readily detectable in individual immune cells of the decidua, and these levels are further enhanced specifically in decidual macrophages during high-dose infections that result in fetal expulsion. Unexpectedly, inductive perforin-2 expression in decidual macrophages did not occur during milder infections in which fetal viability remained intact. This pattern of expression significantly differed from that observed in splenic macrophages in which inductive perforin-2 expression was observed in both high and mild infection conditions. In the placenta, inductive perforin-2 expression in decidual macrophages was coincident with their polarization from a CD206+ MHC class IIlo to CD206− MHC class IIhi phenotype that normally occurs in the placenta during high-burden infections. Our results suggest that perforin-2 is part of a host response that is protective either for both the mother and fetus in milder infections or exclusively for the mother during high-dose infections.
Prevalence of Refractive Errors and Intention to Use Prescription Glasses Regularly Among Secondary School Students in Ogijo Community, Ogun State, Nigeria
Authors: Osayamwen Oghosa W. , Amosu Ademola 
Published: August 2020

Purpose: This study was conducted to assess the prevalence of refractive error among secondary school students, as well as their intention to use prescription glasses regularly.Methods: This was a cross-sectional school-based study with a qualitative component. A total of 359 secondary students aged 11-22years, were selected by multistage sampling method from seven schools in Ogijo community, Ogun state, Nigeria. Of the 359 students, 353(98.3%) were examined. The examination included Visual acuity measurement, ocular motility tests, retinoscopy & autorefraction under cycloplegia, and anterior & posterior segment examination. The data collected were analysed using the statistical package for social sciences (SPSS).Results: The prevalence of refractive error was 11.6%, and of the 41 participants who had refractive error, 65.9% were females while 34.1% were males. Myopia was at 5.1%, while hyperopia and astigmatism were 3.7% and 2.8% respectively. Participants had adequate information (`x =16.08 SD±2.29) regarding refractive error and the use of prescription glasses, but revealed a lack of motivation towards prescription glasses use (`x15.8 SD±4.2). Overall, participants expressed good intention to regular prescription glasses use (`x =12.89 SD±3.8).Conclusion: Refractive error among secondary students of Ogijo community, Ogun state, Nigeria is relatively high. The students expressed good intention to use prescription glasses regularly if given, but on certain conditions. A comprehensive school health program that incorporates school eye health promotion should be practiced effectively to address the misconceptions regarding the use of prescription glasses among the teachers, parents and students.
Keywords: Refractive errors, Adolescents, School health, community health, Health promotion.
Demographic Assessment of Low Vision in Niger State, Nigeria
Authors: Ike Oforbuike Onyebuchi , Akujobi Augustine Ugochukwu , Ismail Salma Mukhtar , Ike Onyinyechi Vivien 
Published: August 2020

Purpose: The study was conducted to assess the demographic distribution of low vision in Niger State, Nigeria.
Methods: The retrospective cross-sectional study design was adopted. The study sample consisted of 306 low vision patients selected from a total of 12,960 clinical records of patients seen over a 5-year period (2012-2016) in three selected public hospitals in Niger State. Diagnostic criterion for low vision was based on World Health Organization (WHO) definition. Data were analyzed using the Statistical Package for the Social Sciences (SPPS) version 21.0.
Results: The prevalence rate of low vision was 2.36%. There were more males (184; 60.1%) than females (122; 33.9%). The males had a higher proportion of the middle-aged (36-55 years; 33.7%) while the females had more of older adults/elderly (≥ 56 years; 33.6%). Low vision was most prevalent among students (39.2%). Glaucoma (118; 38.6%) was the leading cause of low vision. Albinism accounted for more than half (16/31) of low vision cases amongst children while glaucoma (37/91) and cataract (38/91) accounted for 82.5% of low vision cases among older adults/elderly. The majority (115; 37.6%) of patients had severe low vision (VA < 6/60 to 3/60). The uptake of low vision devices was high (217; 70.9%) and the spectacle magnifier (70; 22.9%) was mostly dispensed.
Conclusion: The study has provided baseline information on the demographics of low vision in NigerState, Nigeria which could be the basis for the planning of low vision services in the State.
Keywords: Demographic, assessment, low vision, Niger State, Nigeria.
On Partnership of Civilizations
Authors: Popov V. 
Published: August 2020

The article explains the reasons for nomination and traces the dynamics of the contents of the “dialogue of civilizations” and “alliance of civilizations” concepts. The reasons and circumstances that led to the ineffectiveness of attempts at their practical implementation are considered. The corresponding initiatives did not have a genuinely civilizational scale, closing in the framework of two monotheistic religions – Christianity and Islam.The author postulates two sets of problems, around which a possible intercivilizational dialogue is possible -demographic problems and consumption optimization.
The sensitivity of atmospheric blocking to upstream latent heating – numerical experiments
Authors: Steinfeld Daniel , Boettcher Maxi , Forbes Richard , Pfahl Stephan 
Published: August 2020

Abstract. Recent studies have pointed to an important role of latent heating during cloud formation for the dynamics of anticyclonic circulation anomalies such as atmospheric blocking. However, the effect of latent heating on blocking formation and maintenance has not yet been fully elucidated. To explicitly study this cause-and-effect relationship, we perform sensitivity simulations of five selected blocking events with the Integrated Forecast System (IFS) global weather prediction model in which we artificially eliminate latent heating in clouds upstream of the blocking anticyclones. This elimination has substantial effects on the upper-tropospheric circulation in all case studies, but there is also significant case-to-case variability: some blocking systems do not develop at all without upstream latent heating, while for others the amplitude, size, and lifetime of the blocking anticyclones are merely reduced. This strong influence of latent heating on the midlatitude flow is due to the injection of air masses with low potential vorticity (PV) into the upper troposphere in strongly ascending “warm conveyor belt” airstreams and the interaction of the associated divergent outflow with the upper-level PV structure. The important influence of diabatic heating demonstrated with these experiments suggests that the accurate representation of moist processes in ascending airstreams in weather prediction and climate models is crucial for blocking dynamics.
Evidencias de validez y fiabilidad de la versión en español del Children’s Depression Inventory-Short en población peruana
Authors: Ventura-León José , Caycho-Rodríguez Tomás , Tocto-Muñoz Shirley , Torres-Maldonado Maryuri , Curahua-Guillén Karen 
Published: August 2020

Evidence of validity and reliability of the Spanish version of the Children’s Depression Inventory-Short in Peruvian population Abstract: The objective of this study was to examine the validity evidence of the Children’s Depression Inventory-Short (CDI-S; Kovacs, 1992), in Peruvian school children. A total of 1059 children between 7 and 12 years old participated (Mean = 9.73, SD = 1.23). The results revealed the existence of two factors related to strong loads in the exploratory factor analysis, which were corroborated by confirmatory factor analysis with good goodness-of-fit indices (CFI ≥ .97, RMSEA ≤ .04). The reliability of the CDI-S, calculated with the internal consistency method, was good in both factors (ω > .80). We conclude that the CDI-S is a valid and reliable measure in Peruvian children and should be interpreted as a test with two factors (Dysphoria and Negative self-esteem), which is consistent with previous empirical and theoretical studies. Keywords: Validation; reliability; depression; children. Resumen: El presente estudio tuvo como objetivo examinar evidencias de validez y fiabilidad de la versión en español del Children’s Depression Inventory-Short (CDI-S, Kovacs, 1992), en población peruana. Participaron 1059 niños y niñas entre 7 y 12 años (Media = 9.73, DT = 1.23). Los resultados revelaron la existencia de dos factores relacionados con cargas fuertes enel análisis factorial exploratorio, los cuales fueron corroborados mediante el análisis factorial confirmatorio con buenos índices de bondad de ajuste (CFI ≥ .97, RMSEA ≤ .04). La fiabilidad del CDI-S, calculada con el método de consistencia interna, fue buena en los dos factores (ω > .80). Se concluye que el CDI-S es una medida valida y fiable en niños peruanos y debe ser interpretada como una prueba con dos factores (Disforia y Autoestima negativa), lo cual es coherente con estudios empíricos y teóricos previos. Palabras clave: Validación; fiabilidad; depresión; niños.
Root architecture, rooting profiles and physiological responses of potential slope plants grown on acidic soil
Authors: Dorairaj Deivaseeno , Suradi Muhammad Fahmi , Mansor Nursyamimi Syafiqah , Osman Normaniza 
Published: August 2020

Globally, there has been an increase in the frequency of landslides which is the result of slope failures. The combination of high intensity rainfall and high temperature resulted in the formation of acidic soil which is detrimental to the healthy growth of plants. Proper plant coverage on slopes is a prerequisite to mitigate and rehabilitate the soil. However, not all plant species are able to grow in marginal land. Thus, this study was undertaken to find a suitable slope plant species. We aimed to evaluate the effect of different soil pH on root profiles and growth of three different potential slope plant species namely, Melastoma malabathricum, Hibiscus rosa-sinensis and Syzygium campanulatum. M. malabathricum showed the highest tolerance to acidic soil as it recorded the highest plant height and photosynthetic rate. The root systems of M. malabathricum, H. rosa-sinensis and S. campanulatum were identified as M, VH- and R-types, respectively. The study proposed M. malabathricum which possessed dense and shallow roots to be planted at the toe or top of the slope while H. rosa-sinensis and S. campanulatum to be planted in the middle of a slope. S. campanulatum consistently recorded high root length and root length density across all three types of soil pH while M. malabathricum showed progressive increase in length as the soil pH increased. The root average diameter and root volume of M. malabathricum outperformed the other two plant species irrespective of soil pH. In terms of biomass, M. malabathricum exhibited the highest root and shoot dry weights followed by S. campanulatum. Thus, we propose M. malabathricum to be planted on slopes as a form of soil rehabilitation. The plant species displayed denser rooting, hence a stronger root anchorage that can hold the soil particles together which will be beneficial for slope stabilization.
Reliability and validity of the physical activity monitor for assessing energy expenditures in sedentary, regularly exercising, non-endurance athlete, and endurance athlete adults
Authors: Chang Chun-Hao , Hsu Yi-Ju , Li Fang , Tu Yu-Tsai , Jhang Wei-Lun , Hsu Chih-Wen , Huang Chi-Chang , Ho Chin-Shan 
Published: August 2020

Background
Inertial sensors, such as accelerometers, serve as convenient devices to predict the energy expenditures (EEs) during physical activities by a predictive equation. Although the accuracy of estimate EEs especially matter to athletes receive physical training, most EE predictive equations adopted in accelerometers are based on the general population, not athletes. This study included the heart rate reserve (HRR) as a compensatory parameter for physical intensity and derived new equations customized for sedentary, regularly exercising, non-endurance athlete, and endurance athlete adults.

Methods
With indirect calorimetry as the criterion measure (CM), the EEs of participants on a treadmill were measured, and vector magnitudes (VM), as well as HRR, were simultaneously recorded by a waist-worn accelerometer with a heart rate monitor. Participants comprised a sedentary group (SG), an exercise-habit group (EHG), a non-endurance group (NEG), and an endurance group (EG), with 30 adults in each group.

Results
EE predictive equations were revised using linear regression with cross-validation on VM, HRR, and body mass (BM). The modified model demonstrates valid and reliable predictions across four populations (Pearson correlation coefficient, r: 0.922 to 0.932; intraclass correlation coefficient, ICC: 0.919 to 0.930).

Conclusion
Using accelerometers with a heart rate monitorcan accurately predict EEs of athletes and non-athletes with an optimized predictive equation integrating the VM, HRR, and BM parameters.
Assessment of Proximate, Phytochemical and Selected Mineral Content of Acanthus montanus Leaf
Authors: Añuli Nwachukwu, Augusta , Ekwutosi Ogbulie, Toochukwu , Udodi Nwachukwu, Chibuike , Ijeoma Evans-Kemka, Catherine , Chisom Onyekachi, Vivian 
Published: August 2020

Acanthus montanus (Nees) T. Anders belongs to the family Acanthaceae and is one of the most threatened and underutilized species of vegetables in Africa. However the leaves of this plant are part of a consortium infusion (agabada nkwu) given to post-natal mothers within and around Mbaise in Imo State, South Eastern Nigeria, to ensure health and vitality of both nursing mother and child. The proximate, phytochemical and selected mineral contents of the Acanthus montanus leaf were investigated to ascertain the various components. The fresh plant sample was obtained from Ife, Ezinihitte Mbaise Local Government Area of Imo state, Nigeria. The sample was air-dried at room temperature for 72 hours prior to the various analyses, which were done using standard methods. The results of the phytochemical analysis showed 1.60 % flavonoids, 6.67 % tannins, 5.60 % alkaloids, 6.45 % saponins, 0.26 % phytate, 5.41% oxalate, 0.49 % phenol and 0.019 % Hydrogen Cyanide (HCN). The percentage proximate evaluation for moisture content, carbohydrate, protein, fibre, ash content and fat were: 11.85, 37.86, 17.72, 16.70, 10.56 and 5.31 respectively, while the percentage quantities of selected minerals; iron, magnesium, potassium, calcium, phosphorus, sodium, manganese, zinc and copper were: 0.014, 0.569, 3.152, 0.909, 0.089, 0.202, 0.009, 0.010 and 0.001 respectively. Acanthus montanus is reported for its nutritional and medicinal values throughout Africa. The result of this work suggests further exploitation of the parts of Acanthus montanus to unveil more of its potential uses for the treatment of diseases.
Assessment of the Hepatoprotective Activity of Ethanol Seed Extract of Garcinia kola on Carbon Tetrachloride (CCl4)-Induced Liver Toxicity in Albino Rat Models
Authors: Ayuba R. B. , Enemali M. O. , Mairiga J. P. , Haruna G. S. , Ani O. N. 
Published: August 2020

Aims: To assess the effect of G. kola ethanol seed extract on CCl4-induced liver toxicity in albino rats. The qualitative and quantitative phytochemical analysis of the extract was carried out.
Study Design: Randomized block design.
Place and Duration of Study: Department of Biochemistry and Molecular Biology Laboratory of Nasarawa State University, Keffi, Nasarawa State, Nigeria between January and August, 2019.
Methodology: Thirty male albino rats were randomly distributed into six groups of five rats each. Group 1, normal control, Group 2, standard control, groups 3–6, test groups all administered for seven days. Blood samples were collected for biochemical analysis and liver harvested for histology.
Results: Results of phytochemical analysis showed the presence of alkaloids; 1.260±0.00 mg/dl, tannins; 920±0.00 mg/dl, flavonoids; 2.045±0.00 mg/dl, Carbohydrates; 2.00±0.00 mg/dl, Steroids; 0.012±0.00 mg/dl and Cardiac glycosides; 1.25±0.00 mg/dl, saponins, terpenes and anthroquinones were absent. AST in groups 3, 4 and 5 were significantly (p < 0.05) higher when compared to control. ALT was significantly (p < 0.05) higher in all the treatment groups (4, 5, 6) compared to the control groups (1 and 2). ALP activity increased significantly (p < 0.05) in all the test groups compared to the normal control. Total bilirubin increased significantly (p < 0.05) in all the treatment groups compared to the controls. Direct Bilirubin was significantly (p < 0.05) higher in the treatment groups (5, 6) compared to the normal control. GSH decreased significantly (p < 0.05) in all treatment groups compared to the control. CAT and SOD showed no significant (p > 0.05) difference in the treatment groups when compared to the control groups. Photomicrographs of the liver showed ballooning degeneration with complete loss of nuclear material.
Conclusion: The administered doses in this study did not protect against CCl4 induced liver toxicity in albino rats.
Study and Analytical Modeling of the Influence of Technological and Geometric Parameters on the Performance of Ga0:67In0:33P=GaAs=Ga0:70In0:30As Tri-junction Photovoltaic Solar Cells
Authors: Ndorere N. , Kounouhewa B. , Agbomahena M.B. 
Published: August 2020

In the context of global energy consumption, the production of photovoltaic solar energy remains very low. One solution to this problem is to use multi-junction solar cells with high efficiency. Efforts are being made to increase the efficiency of solar cells and reduce their cost of production. In order to optimize the performance of multi-junction solar cells, this paper presents an analytical model allowing to study and model the influence of technological and geometric parameters on the performance of tri-junction solar cells Ga0:67In0:33P=GaAs=Ga0:70In0:30As. These parameters are the thickness, doping and Gap energy of the three sub-cells making up the tri-junction solar structure. The thicknesses and doping of the emitters (bases) of the sub-cells are varied and chosen in order to optimize the efficiency of the Trijunction Solar Cell (TJSC) Ga0:67In0:33P=GaAs=Ga0:70In0:30As. The one hand, the base doping (emitter) is selected so as to minimize the dark current and the other hand,to reduce the resistive losses in this region. As for the thickness, it is chosen so as to minimize the recombination phenomena. The simulation results show that for a given thickness, the sub-cell efficiencies have maximums which evolve with the increase in doping. If the doping of the base (or emitter) of the sub-cells increases, there follows a proportional increase in the efficiency. In addition, when the optimal doping and thickness of the bases (or emitters) are reached, above these, they can vary over a wide range without considerably modifying the efficiency of the solar cell. This point about the tolerance ranges is very important for the practical realization of Photovoltaic solar cell structures. These results also show that the optimal performance of the Tri-junction Solar Cell are obtained for the relatively low thicknesses of the bases (or emitters) (100nm-700nm) with high doping values(Nb = 8e + 18cm
Body Mass Index and Clinical Outcomes in Egyptian Women with Breast Cancer: A Multi-institutional Study
Authors: Shaaban Amrou Mamdouh Abdeen , Aziz Ahmed Hassan Abd , Sholkamy Nada , Mokhtar Hoda , Emam Shimaa Anwer , Anter Abeer Hussien 
Published: August 2020

Purpose: The aim of this work was to evaluate the association between body mass index (BMI) and clinical outcomes among Egyptian female breast cancer patients.
Methods: We reviewed the file registry of 629 patients with operable breast cancer regarding age, sex, height, weight, menopausal status, family history of breast cancer, tumor features, TNM arrangement and treatment during the period from January 2006 to December 2012. In our studies, obesity was deﬁned as a BMI of ≥30 kg/m2. The primary objective was to estimate the effect of body mass index on the clinical outcomes of breast cancer patients including DFS and OAS.
Results: A total of 629 patients with a mean age of 51.1 years. Stage III and Stage II presented 52% and 46.6% respectively. Overweight and obese patients represent 60.5% of all patient population. There was no association between tumor stage, grade or menopausal status and BMI. Patients with normal BMI showed a median survival of 95.3 months [CI: 54.6,136.06]. This was significantly higher than overweight and obese patients (p = 0.001). Nearly one-third of patients (29.1%) with normal BMI experienced disease relapse compared to 32.8% for overweight and obese patients, however, this was statistically not significant (0.097).
Conclusion: According to the results of this retrospective study, increased BMI may be associated with less favorable prognosis of breast cancer patients.