bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination and pharmacokinetics of calycanthine in rat plasma by UPLC-MS/MS
Authors: Lu Meifei , Lu Xiaojie , Yu Zheng , Wen Congcong 
Published: May 2020

AbstractCalycanthine is an important class of alkaloids extracted and isolated from the roots, leaves, flowers and fruits of Chimonanthus praecox. In this work, the UPLC-MS/MS method was used for determination of calycanthine in rat plasma, and the pharmacokinetics in rats were investigated. Midazolam was used as an internal standard (IS), and methanol precipitation method was used to pretreatment the rat plasma samples. Chromatographic separation was achieved on a UPLC BEH C18 (50 × 2.1 mm, 1.7 μm) column with the mobile phase of methanol- 0.1% formic acid aqueous solution with gradient elution. Multiple reaction monitoring (MRM) mode with positive ionization was applied for quantitative analysis, m/z 347.3 → 246.7 and 326.2 → 291.4 for calycanthine and IS, respectively. The results indicated that within the range of 1–200 ng/mL, linearity of calycanthine in rat plasma was good (r > 0.995), and the lower limit of quantification (LLOQ) was 1 ng/mL. Accuracy range was between 90.6 and 109.4%, precision (RSD) of calycanthine was less than 14%. The matrix effect was between 97.9% and 105.4%, the recovery was better than 85.6%. The developed UPLC-MS/MS method was successfully applied in the pharmacokinetics of calycanthine in rats after oral and intravenous administration. The absolute bioavailability of the calycanthine was 37.5% in rats.
Problems and trends of legal regulation of the heat energy market in the Russian Federation and legal support of competition in the heat energy market
Authors: Romanova V. V. 
Published: May 2020

Despite the seemingly active development of legal regulation of the heat energy market, there are gaps and contradictions in the legal regulation, in the legal provision of competition in the heat energy market, which draw the attention of representatives of the expert community and government agencies. A significant number of legal disputes in the field of heat supply and acts of the constitutional Court of the Russian Federation also indicate problems in legal regulation. Based on the results of legal analysis of legal regulation and law enforcement practice, proposals were made to introduce the following provisions into the model of legal regulation: maintaining a register of companies that sell heat energy, including data on the financial, technological, and personnel status; licensing the activities of companies that sell heat energy; licensing of companies that provide services to heat networks and heat supply facilities, including heat‑receiving equipment for consumers; introduction of a system for intelligent accounting of heat consumption.
Features and legal problems of territorial planning in the power industry
Authors: Romanova O. A. 
Published: May 2020

In the article system of territorial planning in the power industry are examined, territorial planning within the system of strategic planning of the power industry is situated. It’s shown that the main objective of territorial planning in the power industry is the long‑term reservation areas necessary for the next location of energy facilities planned for construction and renovation. The author considers main problems of territorial planning in the power industry are the high level of technological and environmental hazards of the majority of planned energy facilities, the necessity to establish areas with special circumstances, when the use of land and plots of land is restricted, the lack of legal mechanism ensuring compliance with environmental requirements when the location of energy facilities are determined.
Russia’s mineral resource base development till 2035: control at the level of federal districts
Authors: Kim V. V. 
Published: May 2020

In this article, the author concludes that the institution of plenipotentiaries of the President in the federal districts is a legal tool of the President of Russia, which was created to facilitate the exercise of his powers in the federal districts, which can and should be applied in the process of monitoring the implementation of the Development Strategy Implementation Plan mineral resource base of Russia until 2035, even despite the fact that authorized representatives in federal districts are not indicated in the text of the Strategy as part of controlling persons. The territorial bodies of the Federal Subsoil Use Agency (Rosnedra), established at the level of federal districts, should be the conductors of this control: the provisions on the establishment of territorial bodies of the Rosnedra at the level of federal districts contain regulatory provisions that allow direct interaction with the Presidential plenipotentiary representatives in federal districts. In addition, Presidential Decree No. 849 of May 13, 2000, which established federal districts and plenipotentiaries, directly indicates the possibility of plenipotentiaries to monitor the implementation of orders of the Government of Russia — the Strategy was approved in the form of a government order.
The restructuring of the debtor as a means bankruptcy warnings under european law legislation
Authors: Mastilovic L. 
Published: May 2020

Directive on preventive restructuring 1023/2019 (hereinafter referred to as the Directive) guarantees the right of bona fide and prospective commercial entities (hereinafter‑debtors) to initiate a preventive restructuring procedure in the absence of signs of bankruptcy, subject to the mandatory consent of the debtor and the majority of creditors, while, if the disagreement of the majority of creditors is not economically justified, the procedure can be approved by the authorized body (hereinafter — the court). The purpose of the procedure is to prevent bankruptcy in advance. A significant common characteristic of preventive restructuring and bankruptcy proceedings is the collective extension of legal consequences to all creditors, including those who disagree, because a single legal will is economically necessary to achieve the goal. In addition, it prohibits any of the creditors, including those from the dissenting minority, from starting enforcement proceedings (bankruptcy proceedings or enforcement proceedings) at a certain period, even if there are grounds provided for by law, since the legal consequences apply to all creditors, which ensures the incentive and effectiveness of the measures taken and avoids a conflict of creditors due to different assessments of the economic situation and prospects of the debtor.
Resultados de la biopsia por colposcopia en pacientes con citología PAP II y cambios por PVH
Authors: González Mazuelo Antonio , Villota Cadena Néstor Oswaldo , Echavarría Luis Guillermo , Jiménez Zuluaga María Elena 
Published: May 2020

Se realizó una revisión de las 245 pacientes enviadas a Colposcopia por citología PAP II más cambios virales, en un período de 3 años, se encontró en la biopsia dirigida un 68,16% de lesión por condiloma, un 31,42% asociado a NIC y un 0.4% con cáncer invasor.Esto confirma los informes de la relación de PVH y cáncer de cérvix y por lo tanto la necesidad de colposcopia y biopsia en las pacientes con citologías PAP II y cambios virales (coilocitos, disqueratocitos, binucleación).
Detección precoz del cáncer de cuello uterino mediante colposcopia. Informe de 559 casos
Authors: Olarte G. E. , Arango G. R. , López G. G. , Jaramillo E. V. , Betancourt S. L. , Trujillo M. S. , Urrego M. O. , Vanegas M. P. , Vallejo M. T.G. 
Published: May 2020

Con el propósito de efectuar diagnóstico precoz y tratamiento del cáncer de cuello uterino en el Departamento de Caldas, Colombia, S.A., se creó un grupo interdisciplinario o institucional descentralizado, que desde junio de 1989 se desplaza periódicamente y en forma continua a los Hospitales Regionales del Departamento de Caldas, para hacer actividades de prevención, educación a población de riesgo, adolescentes y detección del cáncer del cuello uterino. El ginecólogo practica colposcopia a todas las mujeres con citología anormal compatible con NIC o infección por VPH. Entre junio de 1989 y junio de 1992, se realizaron 559 colposcopias de primera vez; se diagnosticaron 152 casos de NIC y 21 casos de cáncer avanzado. La edad promedio para Ca. microinvasivo e invasivo es de 47.5 años; de 33.9 años para lesiones preinvasoras. El 79.5% de mujeres tuvo relaciones sexuales antes de los 20 años y en la colposcopia se encontraron lesiones en el 60% de los casos, siendo el punteado y la zona acetoblanca los cambios más frecuentes. En 41 colposcopia se observaron vasos atípicos o lesiones clínicamente invasoras. De 404 biopsias tomadas se detectaron 21 carcinomas de tipo escamocelular, 4 microinvasores y 17 invasores.
El 88 % de las lesiones fueron intraepiteliales. La sensibilidad de la colposcopia frente a la biopsia fue de 94 % y la especificidad del 46 %. El 97 % de los pacientes con PAP compatible con NIC-CA, presentaron algún tipo de lesión col poscópica. El promedio de edad de los pacientes con NIC fue 13.8 años menor que los pacientes con carcinoma invasor.
El 100% de la población estudiada es de clase económica baja y 42% de zona rural. Se efectuaron tratamientos en el Hospital Regional consistentes en Crioterapia conización, histcrectomía simple o ampliada; según el caso o radioterapia a nivel central. El programa ha posibilitado detectar un gran número de lesiones pre-invasoras, cuyo tratamiento oportuno ha permitido mejorar las condiciones de salud de la población y racionalizar los recursos, demostrándose los beneficios de una atención regionalizada con colposcopia.
Además ha permitido determinar características colpo-citohistológicas y epidemiológicas.
Diseño de paisaje para el bienestar humano:pautas de diseño
Authors: Largaespada Estephania 
Published: May 2020

Un proyecto arquitectónico que es fuertemente concebido como un diseño integral, relacionando aspectos del entorno cultural, sistemas político - económicos y el desarrollo urbanístico, no puede dejar de lado el diseño paisajístico.
A través de este artículo, se busca evidenciar la importancia del entorno natural en la vida del ser humano. Además brindar una nueva perspectiva hacia el paisajismo como un recurso promotor de la salud y el bienestar físico, mental y social.
Se plantea el aprovechamiento los recursos naturales como medio para fomentar el bienestar de la población costarricense como una iniciativa a seguir. Se establecen una serie de pautas y directrices con el fin generar una guía para ser aplicada en proyectos arquitectónicos y poner en evidencia el potencial que tiene el paisajismo como recurso promotor de la salud pública.
Partnerships in mathematics and science teacher preparation in Zimbabwe
Authors: Matorevhu Alois 
Published: May 2020

<p class="ABS-C">Research evidence indicates that collaborative partnerships among stakeholders develop strong sense of ownership, interest and commitment, which promotes successful programme implementation. Research evidence also supports that loose partnerships adversely affect programme implementation. This study sought to explore the nature of partnerships among teacher education stakeholders in the pre–service Diploma in Education programme, offered at Teachers’ College S which is an associate of the University of Zimbabwe. Interviews with mentor teachers, pre-service teachers on attachment teaching practice/practicum, and head teachers were used to generate and collect data. Findings revealed existence of collaborative partnerships among Teachers’ College S, schools and the University of Zimbabwe. However, most mentor teachers expressed concern on absence of a policy guiding their operations. Recommendations to strengthen collaborative partnerships in pre–service teacher preparation were made.</p>
EXPRESSIVE SPEECH ACTS IN THE STATUSES OF THE FACEBOOK USERS
Authors: Syafitri Widdya 
Published: May 2020

This research is conducted based on two purposes; they are to identify the types of expressive speech act found in the statuses of the Facebook users, and to explain the modes of expressive utterance used in the statuses. Therefore, the data source is the social network that is Facebook and the data are the statuses of the Facebook users. The data are collected by using observational method, followed by non-participant observational technique and taking-note technique. The data analysis is based on pragmatic identity method proposed by Sudaryanto (2015) which is also supported by the theory of the types of expressive speech act by Ronan (2015), and theory about the modes of utterance from Alwi, et al (2000). The analysis result shows that there are fourteen types of expressive speech act in the statuses. They are the expression of agreement, disagreement, apology, gratitude, sorrow (sadness), exclamation (complaint), volition (hope), anger, disappointment, encouragement, satire, annoyance, pride, and congratulation. Meanwhile, the modes of expressive speech act that are used consist of declarative mode, interrogative mode, and exclamative mode. The importance of this research is to reveal or show that there is something else the Facebook users want to say behind their statuses. Sometimes, they do not really state what they mean in their statuses. They use indirect way and there lies the use of expressive speech act which can be stated in different way.
Dermatobiosis cutánea bovina en la región selvática lluviosa y montañosa de México
Authors: Jimenez Cristóbal Hernández , Ojeda Robertos Nadia Florencia , Vivas Roger Ivan Rodríguez 
Published: May 2020

Se reporta la presencia de Dermatobia hominis en bovinos criados en ranchos ubicados en una zona selvática y montañosa de México. Se realizó un estudio en cuatro ranchos, incluidos por conveniencia. Se incluyeron un total de 75 bovinos, se registró la presencia, el número y características de los nódulos cutáneos por animal, y se colectaron larvas. Las larvas fueron clasificadas taxonómicamente como D. hominis. En total 10.6% de los animales presentaron nódulos en la piel (8/75). Se encontraron entre uno y 22 nódulos por bovino, distribuidos en cuatro regiones corporales (cola, pierna, abdomen y escápula). Se detectó la presencia de larvas D. hominis, las miasis que producen se caracterizan por la presencia de nódulos en la escápula, cola y pierna. Se recomienda que en la zona de estudio se implementen medidas de control de la mosca a través del uso de antiparasitarios en los bovinos.
Respuesta al estrés por salinidad de familias s1 de dos poblaciones de maíz
Authors: Velázque-Ventura Julio César , Rincón-sánchez Froylán , Ruiz-Torres Norma Angélica , Martínez-Reyna Juan Manuel 
Published: May 2020

La salinidad es uno de los factores abióticos limitantes de la producción. El objetivo de la presente investigación fue determinar la respuesta de líneas S1de dos poblaciones de maíz en condiciones de estrés por salinidad y su relación con el rendimiento de grano. El material genético consistió de 100 Líneas S1que se sometieron a evaluación con y sin estrés por salinidad en laboratorio e invernadero, y la evaluación del rendimiento de grano. En laboratorio se determinó el porcentaje de germinación (GERM); en invernadero y laboratorio, el peso seco de raíz (PSR) y el peso seco de vástago (PSV). En laboratorio, se encontró una disminución en la respuesta del 72.1% en GERM, y de 40.1 y 44.1% para el PSR y PSV, respectivamente; en invernadero, solo el PSV siguió el patrón de respuesta a las condiciones de estrés, con una disminución del 33.0%. El PSR y PSV bajo estrés en invernadero (PSR_EI y PSV_EI) se correlacionaron de forma positiva con PSV_NL con valores de r = 0.282** y r = 0.185, respectivamente. El PSR y PSV sin estrés en invernadero (PSR_NI y PSV_NI) se correlacionaron de forma positiva con el rendimiento de grano con valores de r = 0.250* y r = 0.237*, respectivamente. Se encontró variación genética entre líneas S1 en los caracteres estudiados, incluyendo el rendimiento de grano. Se considera al peso seco de raíz (PSR) y de vástago (PSV) con y sin estrés en ensayos de invernadero como atributos con potencial para realizar selección temprana de genotipos de maíz.
Fertilización en rambután (Nephelium lappaceum L.) para mejorar la calidad de frutos
Authors: Reyes-Moreno Manuel , García-Villanueva Eduardo , Chávez-Franco Sergio , Muratalla-Luna Alfonso , Reyes-Moreno Jesús , Aguilar-Luna Jesús Mao Estanislao 
Published: May 2020

El objetivo del estudio fue evaluar dos fertilizantes aplicados a árboles productivos de rambután (Nephelium lappaceum L.) incluyendo la fertilización edáfica convencional, para incrementar la calidad de frutos. Los tratamientos fueron: Biofertilizante más Bayfolan® (T1),Biofertilizante (T2), Bayfolan® (T3), sin fertilizante (T4), sin fertilizante (T4). El diseño experimental fue completa- mente al azar, con cinco repeticiones y un árbol como unidad experimental. Se cuantificó: apariencia del fruto (AP), color del pericarpio, pérdida de peso, firmeza (F), peso fresco (PF), acidez titulable y oBx. La AP mejoró en 28% en T1, y en T3; la combinación de los fertilizantes mejoró la calidad de los frutos, hasta con 16% oBx y 10% de PF. En tratamientos restantes los frutos perdieron peso (hasta 35%) y F (hasta 41%) a los ocho días después de la cosecha. La fertilización foliar más la fertilización convencional, mejoran la calidad postcosecha y vida de anaquel de los frutos de rambután.
La accesibilidad dotacional como indicador de vulnerabilidad urbana. Un estudio en la ciudad de Popayán (Colombia) = Accessibility as indicator of the urban vulnerability. A study in Popayán city (Colombia)
Authors: Chamorro Gómez Germán Camilo 
Published: May 2020

Resumen La gestión del crecimiento urbano es uno de los más grandes retos que tienen las administraciones públicas durante los procesos de desarrollo urbano; donde la dimensión espacial de la ciudad se debería considerar como un elemento decisivo para combatir la desigualdad social y garantizar el acceso a los de los ciudadanos. Un tipo de vulnerabilidad urbana se puede producir como efecto de la falta de justicia espacial. La distribución inequitativa de dotaciones urbanas públicas dificulta la accesibilidad a grupos poblacionales de rentas bajas, condicionando el desarrollo del nivel de calidad de vida. Se propone analizar la situación en la zona urbana del municipio de Popayán, Colombia, delimitando el concepto de vulnerabilidad a la dimensión físico-urbanística, definiendo la accesibilidad y la condición socioeconómica como las variables a abordar; y las dotaciones de salud, educación y zonas verdes como los elementos a medir.AbstractThe management of urban growth is one of the greatest challenges that public administrations have during urban development processes. The spatial dimension of the city should be considered as a decisive element to combat social inequality and guarantee the access. Sort of urban vulnerability can occur as a result of the lack of spatial justice, where the unequal distribution of public urban endowments hinders accessibility to low-income population groups. It is proposed to analyze the urban area of the municipality of Popayán, Colombia, defining the concept of vulnerability in the physical-urban dimension, defining accessibility and socioeconomic status as the variables to be addressed; the endowments of health, education and green areas as the elements to be measured.
Konsumsi Buah dan Sayur Siswa Sekolah Dasar Penerima Program Gizi Anak Sekolah di Cianjur
Authors: Sinaga Tiurma , Mauludyani Anna Vipta Resti , Nopiany Haiva , Annur Marestry Nuzul 
Published: May 2020

<p>In recent 10 years, Indonesia has experienced chronic nutrition problems in terms of stunting. Almost all people aged older than five years had inadequate vegetables and fruits consumption. The nutrition program for school children (PROGAS) provided breakfast in many schools, particularly those with high stunting prevalence. The study aimed to analyze the fruits and vegetable consumption of elementary school children participating in PROGAS in Cianjur. This cross-sectional study was conducted to 61 students grade 5 and 6 in Public Elementary School Pamoyanan, Cianjur District. This study was done on March-August 2018. Data were collected by interview using a questionnaire, 2x24 hour food recall, and anthropometric measurement. The results of this study indicated that very few (1.6%, 8.2%, and 1.6%) respondents had adequate consumption of staple food, protein source, and fruits, respectively. There was no respondent consumed an adequate amount of vegetables. Staple food was significantly consumed more during the holidays rather than on school days (p=0.035). Fruits consumption was significantly higher during school days compared to holidays (p=0.001). Vegetable consumption was also consumed more during the school day. PROGAS provided a quite large contribution to the nutrient intake so that PROGAS should be continued with a higher amount of vegetables in the menu.</p><p> </p><p>Abstrak</p><p>Dalam waktu sepuluh tahun terakhir, Indonesia menghadapi permasalahan gizi kronis pada anak usia sekolah berupa <em>stunting</em>. Hampir seluruh penduduk usia di atas lima tahun kurang mengonsumsi sayur dan buah. Program Gizi Anak Sekolah (PROGAS) memberikan sarapan di berbagai sekolah, khususnya yang memiliki prevalensi <em>stunting</em> tinggi. Tujuan penelitian ini adalah menganalisis konsumsi buah dan sayur siswa SD penerima PROGAS di Kabupaten Cianjur. Desain penelitian menggunakan <em>cross sectional study </em>dengan 61 responden kelas lima dan enam Sekolah Dasar Negeri Pamoyanan, Kabupaten Cianjur. Penelitian dilaksanakan pada bulan Maret-Agustus 2018. Data diperoleh dengan wawancara menggunakan kuesioner, 2x24 jam <em>food recall</em> dan pengukuran antropometri. Sebagian kecil responden mengonsumsi cukup makanan pokok, lauk pauk, dan buah, secara berturut-turut sebesar 1,6%; 8,2%; dan 1.6%. Tidak ada responden mengonsumsi cukup sayur. Makanan pokok secara signifikan lebih banyak dikonsumsi selama liburan daripada hari sekolah (p = 0,035). Konsumsi buah signifikan pada hari sekolah dibandingkan hari libur (p = 0,001). Konsumsi sayur juga cenderung lebih tinggi di hari sekolah. PROGAS memiliki kontribusi yang cukup besar terhadap kecukupan gizi responden, sehingga PROGAS perlu dipertahankan dengan penambahan penyediaan sayur dalam menunya.</p>
Factors associated with seeking post-abortion care among women in Guangzhou, China
Authors: Wang Hui , Liu Yan , Xiong Ribo 
Published: May 2020

Abstract
Background: In China, the vast majority of induced abortions are performed in public hospitals. However, post-abortion care (PAC) services are provided through the national network of family planning clinics, which are independent of the health care system. The integration of PAC services into abortion clinics in public hospitals is a new concept. This study aimed to assess PAC utilization among abortion patients, and identify the possible factors associated with PAC uptake in Guangzhou, China. Methods: A cross-sectional survey was conducted among 431 women aged 15-43 years in Tianhe district of Guangzhou, China from June to September 2018. We estimated multivariate logistic regression model to examine the factors associated with utilization of PAC services. Results: Less than half (42%) of the participants used PAC services. Married women were 2.7 times significantly more likely to use PAC services than their unmarried counterparts. Immigrants were 52% significantly less likely to use PAC services than non-immigrants. Women who perceived that their fertility could return later and those who did not know were 45% and 61% significantly less likely to use PAC services compared to those who knew that their fertility could return soon after an abortion. Women with limited decision-making autonomy regarding contraceptive use were 54% significantly less likely to use PAC services than those who made such decisions themselves.Conclusions: The findings suggest the need for policies and programs to not only strengthen the provision of PAC services but also promote uptake among disadvantaged sub-groups of women in the study setting.