bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation
Authors: Chilczuk Tomasz , Steinborn Carmen , Breinlinger Steffen , Zimmermann-Klemd Amy Marisa , Huber Roman , Enke Heike , Enke Dan , Niedermeyer Timo Horst Johannes , Gründemann Carsten 
Published: November 2019

AbstractNovel immunomodulating agents are currently sought after for the treatment of autoimmune diseases and cancers. In this context, a screening campaign of a collection of 575 cyanobacteria extracts for immunomodulatory effects has been conducted. The screening resulted in several active extracts. Here we report the results of subsequent studies on an extract from the cyanobacterium Hapalosiphon sp. CBT1235. We identified 5 hapalindoles as the compounds responsible for the observed immunomodulatory effect. These indole alkaloids are produced by several strains of the cyanobacterial family Hapalosiphonaceae. They are known for their anti-infective, cytotoxic, and other bioactivities. Modulation of the activity of human immune cells has not yet been described. The immunomodulatory activity of the hapalindoles was characterized in vitro using flow cytometry-based measurements of T cell proliferation after carboxyfluorescein diacetate succinimidyl ester staining, and apoptosis and necrosis induction after annexin V/propidium iodide staining. The most potent compound, hapalindole A, reduced T cell proliferation with an IC50 of 1.56 µM, while relevant levels of apoptosis were measurable only at 10-fold higher concentrations. Hapalindole A-formamide and hapalindole J-formamide, isolated for the first time from a natural source, had much lower activity than the nonformylated derivatives while, at the same time, being less selective for antiproliferative over apoptotic effects.
Hepatic Microwave Ablation in Challenging Locations
Authors: Smolock Amanda R. , Shaw Colette 
Published: December 2019

AbstractIn recent years, there has been increased utilization of microwave ablation (MWA) in the treatment of soft tissue tumors. MWA has several theoretical advantages over radiofrequency ablation (RFA) by achieving a more rapid and sustained heating of tissues, increased efficacy in tissues with poor thermal conductivity, and less susceptibility to heat sink effect. While its greater power output has led to appropriate caution when applying this energy to soft tissue tumors, many commonly held beliefs regarding contraindications to MWA are unsupported by data and have been passed along based on experience with RFA. The goal of this article is to review the use of MWA in challenging clinical situations along with the existing evidence for its use.
Symptomatic Cerebral Vasospasm after Spontaneous Subarachnoid Hemorrhage: Comparison of Single and Multiple Intra-arterial Treatment with Respect to the Functional Outcome
Authors: Neumann Alexander , Ditz Claudia , Schacht Hannes , Aulmann Linda , Tronnier Volker Martin , Schramm Peter , Küchler Jan Nils 
Published: November 2019

Abstract
Objective In cases of spontaneous subarachnoid hemorrhage (sSAH) and symptomatic cerebral vasospasm (sCVS), multiple intra-arterial treatments (IATs) can be potentially useful for the functional outcome, even if the prognosis is initially poor. But the actual influence of the number of IATs has yet to be clarified. We wanted to assess if there are differences in the functional outcome between patients with a singular IAT and multiple IATs for sCVS after sSAH.
Methods In a single-center study, 405 consecutive patients with nontraumatic SAH were analyzed retrospectively. A total of 126 developed sCVS, and 86 received IAT (32 singular and 54 multiple, i.e., more than one) with nimodipine with or without percutaneous transluminal angioplasty (PTA). Both groups were compared for demographic data, initial treatment (clipping or endovascular), and initial grading (World Federation of Neurosurgical Societies/Fisher classification, intraventricular hemorrhage, and intracerebral hemorrhage). The modified Rankin Scale (mRS) was used to assess functional outcome at the time of discharge and after 3 and 6 months. The development of CVS-associated infarction was assessed by computed tomography (CT). Categorical variables of the patient groups were analyzed in contingency tables using the Fisher exact test, chi-square test, and the Mann-Whitney U test. Statistical significance was accepted at p < 0.05.
Results Patient groups with singular and multiple IATs were comparable concerning demographic data and initial grading. At the end of follow-up after 6 months, both groups showed comparable functional outcomes. A favorable outcome (mRS: 0–3) was observed in 14 of 26 patients (53.9%) with a single IAT and for 29 of 49 patients (59.2%) with multiple IATs. An unfavorable outcome (mRS: 4–6) occurred in 12 of 26 patients (46.1%) with a single IAT and for 20 of 49 patients (40.8%) with multiple IATs (p = 0.420). In the group with a single IAT, 22 of 32 patients (68.8%) developed CVS-associated infarction; 32 of 54 patients (59.3%) showed brain infarcts after multiple IATs (p = 0.259).
Conclusion For patients with sCVS after sSAH, multiple IATs (nimodipine with or without additional PTA) can be applied safely because no significant differences in functional outcome were observed compared with a singular IAT. We conclude that patients should be treated repeatedly if vasospasm reoccurs.
Multiple ACL Revision: Failure Analysis and Clinical Outcomes
Authors: Dini Francesco , Tecame Andrea , Ampollini Aldo , Adravanti Paolo 
Published: November 2019

AbstractAnterior cruciate ligament (ACL) reconstruction represents one of the most successful orthopedic surgical procedures. Nevertheless, ACL revisions are still very frequent, with a small but relevant number of failures. The purpose of this study is to analyze the failure causes and the clinical outcomes of patients who underwent a re-revision ACL reconstruction. Between January 2009 and December 2017, 263 ACL revisions were performed by a single senior surgeon. Seventeen patients (12 males and 5 females) underwent re-revision ACL reconstruction meeting the inclusion criteria. The mean age was 28.4 years (range, 19–41 years). Before the re-revision, the patients were evaluated preoperatively and after a mean follow-up of 29 months (range, 13–58 months). Assessment included subjective and objective evaluations (Lysholm and International Knee Documentation Committee [IKDC]), KT-2000 arthrometer, radiographic study, and preoperative computed tomography scan. Five patients showed a too anterior previous femoral tunnel and seven a too vertical and posterior tibial tunnel; eight meniscal tears were found. Five patients had grade III–IV according to Outerbridge cartilage lesions. IKDC showed a statistically significant improvement (A + B 35%, C + D 65% preop, A + B 82%, C + D 18% postop, odds ratio: 0.1169; p = 0.0083). The mean Lysholm score ranged from 43 ± 9 to 87 ± 7 (p < 0.001). The KT-2000 arthrometer showed a statistically significant improvement from a mean of 5.8 ± 1.4 to 1.5 ± 1.1 (p < 0.001) at last follow-up. Out of 17 patients, only 4 returned to sports activity at the same preinjury levels. Postoperatively at the last follow-up after last revision surgery, no osteoarthritis evolution was observed. This study showed good clinical and radiological results after the last revision ACL surgery in patients with multiple failures of ACL reconstruction but only one-fourth of the patients returned to the same preoperative sport level. Traumatic events, technical errors, and untreated peripheral lesions are the main causes of multiple previous failures; the worst clinical outcomes were found in the patients with high grade of chondral lesions.
Periprocedural Coagulation Status in Percutaneous Interventions
Authors: Singhal Soumil , Uthappa Mangerira Chinnappa 
Published: December 2019

AbstractHemostasis is a very elaborate process, and its knowledge is essential for every interventional radiologist. Abnormal coagulation parameters are associated with an increased risk of bleeding and require appropriate management. This review aims to briefly discuss the pathophysiology of hemostasis, the role of currently available pharmacological agents affecting hemostasis, and the management of hemostasis during various percutaneous interventional procedures. A preprocedure proforma, when used as a checklist, can reduce procedure-related complications.
Bardet Biedl syndrome - report of a very rare case
Authors: Sbirahatti Asha , Dixit Daksha , Patil Harshavardhan 
Published: November 2019

AbstractBardet Biedl Syndrome is a autosomal recessive condition with a wide spectrum of clinical features. The principal manifestations of the syndrome are Post axial polydactyly, Retinitis Pigmentosa, truncal obesity, hypogonadism & renal dysfunction. The authors report a case of Bardet Biedl Syndrome in a young girl diagnosed on the basis of post axial polydactyly, retinitis pigmentosa and other systemic features. Postaxial polydactyly is one of the earliest and most common manifestation of Bardet Biedl syndrome, followed by truncal obesity and retinitis pigmentosa. Renal failure is the major cause of morbidity and mortality. The importance of polydactyly lies in the fact that, such finding can be helpful in antenatal diagnosis to see its inheritance, counseling of such families and at times may be treated by surgical correction.
Surgical anatomy of the posterior ends of the middle and inferior turbinates
Authors: Muthiyan Gayatri Girish , Hattangdi Shanta Sunil , Kasat Payal Arvind 
Published: November 2019

Abstract
Background: Preservation of structure and reestablishment of function is the guiding principle during an endoscopic intervention. Especially, when a partial middle turbinectomy is unavoidable, middle turbinate can lose its stability. Variations of middle turbinate like severe anterior bulging, posterior protrusion beyond the inferior turbinate and the larger size than inferior turbinate have significant impact on its stability. Aim: To study surgical anatomy of the middle and inferior turbinates. Method: The distances and angles between the limen nasi and posterior ends of the middle and inferior turbinates were studied in 100 hemisected adult Indian cadaveric heads. Results: The mean angles between the line passing through the lowermost portion of limen nasi and posterior ends of middle turbinate and inferior turbinate respectively are bl was 19.87° and b2 was 10.57°. The mean distance between the lowermost portion of limen nasi and posterior ends of middle turbinate and of inferior turbinate were xi is 55.88 ± 3.61 mm and x2 was 52.69 ± 3.57 nnn.The mean distances between the lowermost portion of limen nasi and the perpendicular from the posterior ends of middle turbinate and inferior turbinate to the hard palate were yl= 52.47 ± 3.33 mm (range: 44.16 to 59.92 mm) and y2= 51.75 ± 3.45 mm (range 43.32 to 61.22 mm) respectively. In 52% cases middle turbinate extends more posterior with respect to inferior turbinate i.e.M > I and in 48% cases inferior turbinate extends more posterior with respect to middle turbinate of M < I. Conclusion: The documentation of these parameters and the related variations is likely to be useful for the endoscopic surgeons.
Study on correlation of foot length with stature
Authors: AN Kavyashree , MK Bindurani , KR Asha ,   Lakshmiprabhasubhash
Published: November 2019

Abstract
Background and aims : Stature is the height of a person in the upright posture. There are lot of variations in estimating stature from limb measurements among people of different region and race. Hence there is a need to carryout more studies on population of different regions so that method of stature estimation becomes more reliable. The aim of study was to fmd out the correlation between foot length and height of an individual and to derive regression formulae to estimate the height from the foot length in the study population. Materials and methods : This study was conducted among 308 healthy students aged between 18-20 years. Foot length and height was measured. The measurements were made by using standard anthropometric instruments to the nearest millimeter. The data obtained was analysed statistically and attempt was made to findout correlation and to derive a regression formula between foot length and height of an individual. Results: The values of all the parameters in case of male were higher than females. The sex differences in these parameters showed statistical significance. A strong positive correlation between height and foot length of individuals was found Conclusion: Foot length is a useful parameter in stature estimation. Our findings suggest that the relationship between stature and foot length is of practical use for anatomical, medico legal, anthropological, archaeological and other related studies.
Greater palatine foramen- morphometry, sexual dimorphism and clinical perspective
Authors: Patil Manjula , Sheelavant Santosh 
Published: November 2019

Abstract
Background and aims: Maxillary nerve block via greater palatine foramen (GPF) is most commonly followed procedure for many dental, oral and maxillofacial surgeries. Many standard textbooks mention location of GPF in a general way. Location of GPF with respect to fixed bony landmarks has been studied by many authors in different population groups. The results of those studies showed lot of variability in location of GPF. The data regarding possible existence of sexual dimorphism are sparse. The present study was aimed at contributing further data regarding morphometry of the GPF. Ao attempt has also been made to look for sexual dimorphism. Material and Methods: One hundred and twenty three adult dry skulls of known sex (male- 55 & female - 68) were studied for GPF with regards to- morphometry, shape, relation to molars, fixed bony landmarks- Median maxillary suture(MMS), Incisive fossa(IF), Posterior border of hard palate(PBHP), Aogle between line joiniog GPF with IF & MMS, direction of opening of GPF into oral cavity. Results: Aotero-posterior diameter on left side (p-0.006), transverse diameter on both sides (p-0.000 on left & right side) distance between GPF to IF on both sides (p- 0.013 right side, p-0.02 left side, GPF-PBHP distance on both sides (p-0.001 left side, p-0.002 on right side) showed statistical significance when compared male with female skulls. In both male and female skulls, Oval shape predominated followed by round and slit variety of GPF. Both on right and left side GPF found to be predominantly related to anterior half of 3rd molar. Direction of opening of GPF into oral cavity was predominantly antero-medial on both sides in male and female skulls. Conclusion: Our study provides a valuable addition to the available literature on location of GPF and also gives an insight to the possible existence of sexual dimorphism.
Occipital condyles interconnected by a bony bar
Authors: D. Nirmala , N. Hema 
Published: November 2019

AbstractOccipital condyles interconnected by a bony bar is a rare occurrence. During osteology demonstration of skull bones, one skull was identified aspects of the occipital condyles. The bony bar was curved, just below the anterior margin of foramen mangum. There was a gap of about 3 mm between the bony bar and the anterior margin of foramen magnum. The partial or complete assimilation of the atlas with the occipital bone have been reported in literature. The present case deserves attention since this has not been reported earlier.
A rare variation of cutaneous innervation of dorsum of hand by posterior interosseous nerve
Authors: Roy Tapati , Sarkar Jayanta , Ray Koushik , Mandal Lopamudra , Basu Rituparna , Baral Karabi 
Published: November 2019

AbstractAnatomical knowledge of variation of cutaneous supply of hand is required to the anesthetist to give local anesthesia and to the surgeon for various operations around wrist. The present case was reportedto enlighten the knowledge of anatomists as well as to the clinicians. During routine dissection of 70 year old male cadaver a rare variation of distribution of posterior interosseous nerve on dorsum of hand of right side was observed. The adjacent sides of index and middle fingers supplied by posterior interosseous nerve. Cutaneous nerve supply of thumb and lateral side of index finger was by three proper digital branches from superficial division of radial nerve and rest was supplied by ulnar nerve. Anatomical knowledge of this variation willbe useful to anaesthetists and surgeons during various operations.
Chiral and counter-propagating Majorana fermions in a p-wave superconductor
Authors: Hu Haiping , Satija Indubala I , Zhao Erhai 
Published: November 2019

Abstract
Chiral and helical Majorana fermions are two archetypal edge excitations in two-dimensional topological superconductors. They emerge from systems of different Altland–Zirnbauer symmetries and characterized by

Z

and

Z

2

topological invariants respectively. It seems improbable to tune a pair of co-propagating chiral edge modes to counter-propagate in a single system without symmetry breaking. Here, we explore the peculiar behaviors of Majorana edge modes in topological superconductors with an additional ‘mirror’ symmetry which changes the bulk topological invariant to

Z
⊕
Z

type. A theoretical toy model describing the proximity structure of a Chern insulator and a p

x
-wave superconductor is proposed and solved analytically to illustrate a direct transition between two topologically nontrivial phases. The weak pairing phase has two chiral Majorana edge modes, while the strong pairing phase is characterized by mirror-graded Chern number and hosts a pair of counter-propagating Majorana fermions protected by the mirror symmetry. The edge theory is worked out in detail, and implications to braiding of Majorana fermions are discussed.
Fully solvable lower dimensional dynamics of Cartesian product of Kuramoto models
Authors: Chen Zewen , Zou Yong , Guan Shuguang , Liu Zonghua , Kurths Jürgen 
Published: November 2019

Abstract
Implementing a positive correlation between the natural frequencies of nodes and their connectivity on a single star graph leads to a pronounced explosive transition to synchronization, additionally presenting hysteresis behavior. From the viewpoint of network connectivity, a star has been considered as a building motif to generate a big graph by graph operations. On the other hand, we propose to construct complex synchronization dynamics by applying the Cartesian product of two Kuramoto models on two star networks. On the product model, the lower dimensional equations describing the ensemble dynamics in terms of collective order parameters are fully solved by the Watanabe–Strogatz method. Different graph parameter choices lead to three different interacting scenarios of the hysteresis areas of two individual factor graphs, which further change the basins of attraction of multiple fixed points. Furthermore, we obtain coupling regimes where cluster synchronization states are often present on the product graph and the number of clusters is fully controlled. More specifically, oscillators on one star graph are synchronized while those on the other star are not synchronized, which induces clustered state on the product model. The numerical results agree perfectly with the theoretic predictions.
Precise Unmanned Aerial Vehicle Visual Positioning Based on Neural Network
Authors: Zhu Fanghong 
Published: November 2019

Abstract
Unmanned aerial vehicle (UAV) positioning provides a means for human beings to achieve ubiquitous positioning and target tracking in low-altitude areas. The current UAVs mainly rely on satellite navigation and positioning, and airborne inertial devices (gyro) to complete positioning, which makes its signal easy to be blocked and leads to errors accumulation. However, visual positioning is characterized with high local positioning accuracy and good continuity. Therefore, visual positioning is integrated with UAV positioning in this study. First of all, UAV spatial reference acquisition and neural network are studied to analyze the shortcomings of the current UAV positioning technology in application and the necessity of integrating neural network. Second, a precise visual positioning algorithm based on neural network is presented. Based on the neural network model with image matching and position determination, the UAV visual positioning algorithm can be optimized and the redundancy of the target image can be reduced. What’s more, by establishing the experimental environment with Matlab, it is proved that the positioning accuracy can be improved with the algorithm proposed in this study.
Image deblurring based on fractional-order total variation and total generalized variation
Authors: Xie Bin , Huang Hui , Huang An 
Published: November 2019

Abstract
Considering the problem that the traditional method is easy to cause staircase effect and blur detail when removing image blur, we propose a model combined with fractional-order total variation (FOTV) and total generalized variation (TGV) for image deblurring. Firstly, we use the global gradient extraction method (GGES) to divide a blurred image into a smooth portion containing the image features and a detail portion containing the image details. Secondly, we use the TGV method of image deblurring and the FOTV method of image deblurring to repair the two parts of the image separately. Finally, we reconstruct the two restored images together to get the result image. In order to solve the proposed new model effectively, a new numerical algorithm is designed based on the original dual algorithm. The experimental results show that our method is superior to the traditional method in removing the staircase effect and maintaining the image detail area.
Considering Sub-graph Structure in Representation Learning
Authors: Fu Wentao , Yang Xiaoyu , Sun Xiyan 
Published: November 2019

Abstract
Representation learning aims to encode knowledge graphs into a low-dimensional vector space. However, since both the out-degree and in-degree of the entities in the knowledge graph follow the power-law distribution, only a small number of entities with higher frequency play a key role in training process, while the others have less effect. This leads to a more serious problem of data sparsity. In this paper, we propose two knowledge graph representation learning models for sub-graph structure fusion. Based on the original model, our models are trained by incorporating the sub-graph structure during training process. By incorporating the sub-graph information into the representation learning model, the structural associations between different relations can be incorporated while considering the semantic association between entities. So that the entities and relations can be modeled more accurately, and the data sparsity problem of the knowledge graph representation learning model can be alleviated effectively.
Research on Big Data Analysis Technology of Chinese Traditional Culture Yue embroidery Color Network
Authors: Zhe Zhang , Wang Qinghai , Xing Yadan 
Published: November 2019

Abstract
With the rapid development of big data technology, it is necessary to transform the color elements of Guangdong embroidery in Chinese traditional cultural phenomena into data resources that can be stored and analyzed for its sustainable development. It is the requirement of the times for the development of modern design field. Based on the big data technology, this paper extracts the traditional Chinese Guangdong embroidery color with Chinese national representative by K-Means clustering method, and puts forward a method to judge the saliency of the color characteristics of cultural phenomena, and studies the color characteristics of traditional Chinese cultural phenomena.