bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Approach to Assessing Differentiation Degree and Lymph Node Metastasis of Extrahepatic Cholangiocarcinoma: Prediction Using a Radiomics-Based Particle Swarm Optimization and Support Vector Machine Model
Authors: Yao Xiaopeng , Huang Xinqiao , Yang Chunmei , Hu Anbin , Zhou Guangjin , Ju Mei , Lei Jianbo , Shu Jian 
Published: September 2020

Background
Radiomics can improve the accuracy of traditional image diagnosis to evaluate extrahepatic cholangiocarcinoma (ECC); however, this is limited by variations across radiologists, subjective evaluation, and restricted data. A radiomics-based particle swarm optimization and support vector machine (PSO-SVM) model may provide a more accurate auxiliary diagnosis for assessing differentiation degree (DD) and lymph node metastasis (LNM) of ECC.

Objective
The objective of our study is to develop a PSO-SVM radiomics model for predicting DD and LNM of ECC.

Methods
For this retrospective study, the magnetic resonance imaging (MRI) data of 110 patients with ECC who were diagnosed from January 2011 to October 2019 were used to construct a radiomics prediction model. Radiomics features were extracted from T1-precontrast weighted imaging (T1WI), T2-weighted imaging (T2WI), and diffusion-weighted imaging (DWI) using MaZda software (version 4.6; Institute of Electronics, Technical University of Lodz). We performed dimension reduction to obtain 30 optimal features of each sequence, respectively. A PSO-SVM radiomics model was developed to predict DD and LNM of ECC by incorporating radiomics features and apparent diffusion coefficient (ADC) values. We randomly divided the 110 cases into a training group (88/110, 80%) and a testing group (22/110, 20%). The performance of the model was evaluated by analyzing the area under the receiver operating characteristic curve (AUC).

Results
A radiomics model based on PSO-SVM was developed by using 110 patients with ECC. This model produced average AUCs of 0.8905 and 0.8461, respectively, for DD in the training and testing groups of patients with ECC. The average AUCs of the LNM in the training and testing groups of patients with ECC were 0.9036 and 0.8889, respectively. For the 110 patients, this model has high predictive performance. The average accuracy values of the training group and testing group for DD of ECC were 82.6% and 80.9%, respectively; the average accuracy values of the training group and testing group for LNM of ECC were 83.6% and 81.2%, respectively.

Conclusions
The MRI-based PSO-SVM radiomics model might be useful for auxiliary clinical diagnosis and decision-making, which has a good potential for clinical application for DD and LNM of ECC.
INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION BY AN EXTRACT OF OCIMUM BASILICUM SEEDS: AN IN-VITRO STUDY
Authors: RAVINDRAKUMAR K PATEL , SANDIP B PATEL 
Published: September 2020

Objective: Ocimum basilicum (OB) has been used to treat diverse illnesses which include urinary stone disorder for a reason that historical time in India. We investigated OB seeds for antiurolithic activity.
Methods: Calcium oxalate crystallization becomes triggered by the addition of 0.01 M sodium oxalate answers in normal human urine and nucleation was done.
Results: OB seeds were discovered to be robust and promising antiurolithiatic agents which are in accordance with its use in traditional medication.
Conclusion: An extract of the traditional herb OB has super inhibitory activity on crystalluria and therefore might be useful in dissolving urinary stone; however, in addition, a study in animal fashions of urolithiasis is needed to assess its capability antiurolithiatic interest.
DEVELOPMENT AND VALIDATION OF A FAST AND SENSITIVE UHPLC-PDA METHOD FOR THE QUANTIFICATION OF URSOLIC ACID IN POLY(L-LACTIC ACID) NANOCAPSULES
Authors: CARLETTO BRUNA , LYRA AMANDA MARTINEZ , KOGA ADRIANA YURIKO , NOVATSKI ANDRESSA , MAINARDES RUBIANA MARA , LIPINSKI LEANDRO CAVALCANTE , FARAGO PAULO VITOR 
Published: September 2020

Objective: The aim of the present study is to develop and validation of a ultra-high performance liquid chromatography (UHPLC) method to determine the ursolic acid content and its encapsulation efficiency (EE) in lipid-core nanocapsules prepared from poly (L-lactic acid).
Methods: A simple UHPLC-PDA method was developed and validated for the quantitative determination of ursolic acid in poly(L-lactic acid) nanocapsules. The chromatographic conditions used were: RP-C18 column, isocratic mobile phase containing acetonitrile:water (92:8, v/v), flow rate of 0.8 ml/min, column temperature of 50°C, and detection at 203 nm. The following parameters were evaluated: Specificity, linearity, limits of detection and quantification, precision, accuracy, and robustness.
Results: The method was specific to the ursolic acid and linear (r=0.9998) in the range of 10–100 μg/ml. The limits of detection and quantification were 1.35 and 4.10 μg/ml, respectively. The precision was demonstrated by a relative standard deviation less than 2%. Adequate accuracy (98.35%±0.82) was obtained. Changes in flow rate, mobile phase, and column temperature did not significantly alter the peak area and the retention time of the ursolic acid. The mean EE was 99.89%.
Conclusion: The method proved to be fast, sensitive, and simple for quantifying ursolic acid in nanocapsules and was successfully used for determining the EE.
FORMULATION AND EVALUATION OF CELECOXIB CREAM AND ITS RELEASED STUDY
Authors: ANWAR SADIA , JAN SYED UMER , GUL RAHMAN 
Published: September 2020

Objective: The purpose of this study was to formulate and evaluate of Celecoxib cream and it’s in vitro release study.
Methods: The release study was conducted, using dialysis cellulose membrane, in Franz cells. The donor chamber was filled with phosphate buffer pH 7.4, released medium were analyzed by UV-Vis spectrophotometer at 250 nm. Kinetics model was used for calculations. The cream was followed by different evaluations like pH measurement, homogeneity, spreadability, stability study, drug content, SEM, XRD studies and skin irritation test was used for the reliability of physical conditions and chemical relation. DD solver and SPSS were used for statistical analyzation of the data.
Results: The best in vitro drug release profile achieved with thyme oil in Celecoxib cream. Formulation F2 showed the highest (83%) released. The results of the Celecoxib (1%) were suitable in all constraints. The prepared Celecoxib cream was encouraging for the formulation of transdermal drug delivery.
Conclusion: The Celecoxib cream was successfully prepared and could be beneficial for transdermal drug delivery.
ANTIBIOTIC SENSITIVITY PATTERN OF BACTERIA ISOLATED FROM THE ENVIRONMENT OF INTENSIVE CARE UNIT OF WAD MEDANI EMERGENCY HOSPITAL, GEZIRA STATE, SUDAN
Authors: MOHAMMED WALEED ELSIDDIG , HASSAN HASSABELRASOUL ELFADIL , YOUSIF MIRGHANI ABDELRHMAN 
Published: September 2020

Objective: The objective of the present study was primarily to identify the sources and types of bacterial contamination associated with hospital-acquired infections in the intensive care unit and to investigate the sensitivity pattern of isolated bacteria to prescribed antibiotics of Wad Medani Emergency Hospital, Gezira State, Sudan.
Methods: A total of 50 swab samples were obtained from 14 different sites, including inanimate objects as well as nurses’ hands in the ICU. Identification of the bacterial isolates was performed utilizing Gram’s staining test and standard biochemical tests; likewise, the respective antimicrobial sensitivity was determined based on the guidelines recommended by the Clinical and Laboratory Standards Institute (CLSI).
Results: Showed the prevalence of Gram-positive isolates as Coagulase-negative staphylococci (30%), Staphylococcus aureus (20%), Bacillus spp (15%), and Streptococcus spp (4%). On the other hand, the Gram negative isolates were: Pseudomonas aeruginosa (11%), \Kliebsiella pneumoniae (7%), Proteus mirabilis (5%), and Enterobacter spp.(5%). Floor, Monitors, Patients’ oxygen masks and infusion-stands as well as nurses’ hands, were the most contaminated sites. Staphylococci showed a reasonable sensitivity response to Gentamicin and Vancomycin and high resistance to Erythromycin and Co-trimoxazole; whereas Gram-negative isolates showed high resistance to first and second-generation Cephalosporins and demonstrated good sensitivity pattern to Gentamicin and Meropenem. Pseudomonas aeruginosa also showed reasonable sensitivity to Ciprofloxacin.
Conclusion: Findings of the study demonstrated high bacterial contamination levels in ICU.
A comparative network meta-analysis of standard of care treatments in treatment-naïve chronic hepatitis B patients
Authors: Sbarigia Urbano , Vincken Talitha , Wigfield Peter , Hashim Mahmoud , Heeg Bart , Postma Maarten 
Published: September 2020

Objective:
Published network meta-analyses of chronic hepatitis B (CHB) treatments are either out-of-date or excluded key treatments. Therefore, we aimed to comprehensively update the efficacy evidence for the following end points: Hepatitis B surface antigen (HBsAg) loss, hepatitis B early antigen (HBeAg) seroconversion and hepatitis B virus DNA (HBV DNA) suppression.
Materials & methods:
Approved treatments in CHB and their combinations were evaluated. A systematic literature review was conducted to identify all randomized controlled trials in treatment-naïve CHB patients. Included studies reported at least one of the end points of interest. A frequentist probability network meta-analysis was performed for each end point. The choice of fixed effect or random-effect model was based on the I-square statistic, a measure of variation in study outcomes between studies. The analyses were performed separately for HBeAg-positive and HBeAg-negative patients. For the primary analyses, end points measured 48 ± 4 weeks after treatment initiation were considered.
Results:
A total of 47 randomized controlled trials (13,826 patients), covering 23 unique treatment regimens, were included: a total of 29 reported HBsAg loss, 36 reported HBeAg seroconversion and 37 reported HBV DNA suppression. For both HBsAg loss and HBeAg seroconversion, pegylated interferon-based regimens were the most effective strategy in both HBeAg-positive and HBeAg-negative patients. On the other hand, for HBV DNA suppression, nucleosides-based regimens were the most effective strategy in both HBeAg-positive and HBeAg-negative patients.
Conclusion:
Our findings confirm available evidence around the comparative efficacy of available CHB treatments. Therefore, they can be used to update relevant cost–effectiveness analyses and clinical guidelines.
PENGARUH PROFITABILITAS, PERTUMBUHAN PENJUALAN, STRUKTUR AKTIVA DAN UKURAN PERUSAHAAN TERHADAP STRUKTUR MODAL PADA PERUSAHAAN PROPERTY DAN REAL ESTATE YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Harina Elsa Tria 
Published: September 2020

The study aims to analyze: 1) the influence of profitability to capital structure , 2) the influence of growth of sales to capital structure 3) the influence of asset structure to capital structure and 4) the influence of firm size to capital structure. This research is causative research. The population in this research is property and real estate company registered in BEI in 2011 until 2016. Sample was determined by purposive sample method and 20 companies were selected as sample. The data used in this research is secondary data obtained from www.idx.co.id. Data collection techniques with documentation techniques. The analytical method useds multiple linear regression analysis with SPSS version 21 for windows. The result showed that the profitability has positive effect significant on capital structure, growth of sales has negative effect insignificant on capital structure, asset structure has negative effect insignificant on capital structure and firm size has positive effect significant on capital structure. Determination of capital structure is an important issue for every company because good and bad capital structure will have a direct effect on the company's financial position. Therefore companies should pay attention to selected funding decision. Keyword: Capital Structure, Profitability, Growth of Sales, Asset Structure, Firm Size
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI UTANG LUAR NEGERI DI INDONESIA
Authors: Saputra Defrizal , Aimon Hasdi , Adry Melti Roza 
Published: September 2020

This study aims to determine and analyze the factors that influence foreign debt in Indonesia with variables that effect economic growth, inflation, and foreign interest rates. This type of research is associative descriptive research, where the data used is secondary data from 1970 to 2017 obtained from institutions and related institutions, which are analyzed using the Error Correction Model (ECM) method. This study initially used the Ordinary Lest Square (OLS) method to see long-term, and used ECM because it wanted to see short-term at the same time. The findings of this study indicate that economic growth and inflation have a significant effect in the long run, but the interest rates have no significant effect, and in the short term all have a significant effect on foreign debt in Indonesia. Keywords: foreign debt, economic growth, inflation, interest rates and error correction model (ECM)
ANALISIS KONVERGENSI ANTAR PROVINSI (STUDI KASUS PULAU SUMATERA)
Authors: Budiman Arief , Aimon Hasdi , Yeniwati Yeniwati 
Published: September 2020

This study aims to determine an analyze the influence of foreign direct investment, transfer payment and human development affect capita income. These three variables also used to determine convergence that happenened on the island of Sumatera. Data used from 2012 to 2017involve 10 provinces on the island of Sumatera. This data on this research is secondary data published by the Central Bureau of Statistic. The analytical method used is regression panel to estimate impact dependent variables on capita income. To determine sigma convergence use standart deviation lag of Gross Regional Domestic Income per capita. And to determine beta convergence use Generalized Method Momment (GMM). The result of this study show foreign direct investment, transfer payment and human development have significant impact on per capita income. The result of sigma convergence show the island of Sumatera have sigma convergence from 2012 to 2017. The resut of beta convergence show the island of Sumatera have beta convergence and reach half live convergence in 12 years. Keywords : Convergence, foreign direct investment, transfer payment, human development
ANALISIS DETERMINAN PENGELUARAN KONSUMSI RUMAH TANGGA DI INDONESIA
Authors: Illahi Najmi , Adry Melti Roza , Triani Mike 
Published: September 2020

The study aims to analyze the effect of disposable income , deposi interes ratet, and education on household expenditure in Indonesia. The analytical method used in this study is to use OLS (Ordinary Least Square) analysis. Tests using statistical tests include t test, F and R squared test and classic assumption test. Where all testing using program tools eviews 8.0. Estimation results show the relationship of independent variables of R2 = 0.9877, meaning that 98.77% of diposible income, deposit rates, and education has impact to household expenditure in Indonesia. The results of the data analysis show that disposible income has a positive impact and is significant at α = 5% of household expenditure in Indonesia. Deposit interest rate variables has negative and significant impact to household expenditure in Indonesia and education variables has negative and significant, The economic crisis has a positive and significant impact to household consumption expenditure in IndonesiaKeyword: Disposable Income, Deposit Interes rate,Household Expenditure,Education, Economic crisis
Pelatihan Pembuatan Media Alat Peraga Edukatif (APE) Untuk Anak Usia Dini Bagi Kepala Sekolah Dan Guru Taman Kanak-Kanak Berbasis Kewirausahaan di Kecamatan V Koto Kampung Dalam Kabupaten Padang Pariaman
Authors: Mahyuddin Nenny , Sofya Rani Sofya 
Published: September 2020

Media is an important thing in supporting learning. Media is an intermediary/introduction of learning messages to children so that there is a common perception given by the teacher and received by the child. Provision of media facilities requires the ability of creative teachers to create learning medium so that the material is distributed or delivered to children. Consider in designing the media not only in terms of children's interests but also the compatibility between the media and the material that will be conveyed so that it can be delivered fundamentally accepted by the child. In fact there are still many teachers who do not yet have the ability of creativity in designing educational learning media in learning in kindergarten. Most teachers only use mediocre and monotonous media so that children are not motivated in learning. This greatly affects the success of children's learning. The teacher's ability to design instructional media greatly influences the outcome of learning. Therefore we need special training for teachers to develop and hone the ability of teacher creativity to design educational learning media that are able to support learning in early childhood. The training is carried out in the form of educational learning media design activities that begin from giving examples of educational media, the teacher tries to design media for all themes, determines the message and information to be conveyed, selects tools and materials from various sources that will be used until the teacher makes the media and how to use the media. The training will hone and invite the teacher to think creatively in creating an educational learning media in children's learning Keyword: educative viewer media, entrepreneur
Pengaruh Corporate Governance Terhadap Struktur Modal Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Tahun 2014-2017
Authors: Putri Rahmi Aulia , Zulvia Yolandafitri 
Published: September 2020

This study aims to examine the effect of corporate governance on the capital structure of manufacturing companies listed on the Indonesia Stock Exchange. Companies need an optimal capital structure so that there are no problems that will later impact the risk of high corporate bankruptcy. Capital structure will be optimal if there is no agency problem. Agency problems occur because of differences in interests between managers, investors, and creditors. To reduce agency conflict, corporate governance is needed. Institutional ownership and the size of the audit committee are used in this study as part of corporate governance. Debt to equity ratio was used to measure capital structure in this study. The sample used in this study amounted to 76 manufacturing companies listed on the Indonesia Stock Exchange. The sample selection in this study used a purposive sampling method. The type of data used is secondary data obtained from www.idx.co.id. The analytical method used is multiple regression analysis. The results of the study show that institutional ownership has a significant effect on capital structure, while the audit committee has no significant effect on capital structure. Keywords: capital structure, corporate governance, institusional ownership, audit committee
Pengaruh Kemandirian Belajar dan Persepsi Siswa Tentang Metode Mengajar Guru Terhadap Hasil Belajar Siswa Kelas X Pada Mata Pelajaran Administrasi Umum di SMK Negeri 1 Padang Panjang
Authors: Aulia Zikra , Armiati Armiati 
Published: September 2020

This research is conducted to find out: (1) the influence of learning independence on student outcome, (2) the influence of students’ perceptions about the method of teaching teachers to learning outcomes, (3) the influence of learning independence and students’ perceptions of teacher teaching methods on student outcomes. This rtype of research is descriptive quantitative research. The population of this study was class students X accounting and financial institutions and online marketing businesses in SMK Negeri 1 Padang Panjang consisting of 125 students, the sample of this study was 96 students. Data is collected by documentation and questionnaire. The questionnaire method was used to collect data on learning independence variables and student perceptions od teacher teaching methods that had been tested for validity and reliability, while the documentation method was used to collect variable data on general administration learning outcomes. The analysis prerequisite test included normality test, heteroscedasticity tes and mulitcollinearity test. Hypothesis testing is done using multiple analysis regression analysis. The results of this study are: (1) there is a positive and significant influence of elarning independence on learning outcomes, (2) there is a positive and significant influence of student perceptions od teacher teaching methods on learning outcomes, (3) there is a positive and significant influence on learning independence and student perceptions of teaching methods teacher on learning outcomes. Based on the result of the study, obtained 23% of the influence of learning independence and students’ perceptions of the teacher’s teaching methods on students learning outcomes Keyword: learninig independence, students’ perceptions of teacher teaching methods, learning outcomes
PANTALON CAMPURAN DENGAN METODE TWISTING PATTERN UNTUK PENJAHIT GANG OPEK
Authors: Trisno Rudy , Thedyardi Clinton , Darmady Irene Syona 
Published: September 2020

Kelompok Penjahit Gang Opek adalah kumpulan beberapa penjahit keliling yang mereparasi celana dan masih tersisa belakangan ini. Sebuah isu kompetisi pasar jahitan di daerah produksi pakaian menyebabkan berkurangnya order. Masalahnya, mereka perlahan berganti profesi, atau mencoba menerima order lain untuk menyambung hidup. Jenis pekerjaan yang kerap mereka terima adalah reparasi pantalon. Pantalon adalah istilah pakaian yang merujuk pada sebuah jenis celana yang panjangnya semata kaki. Namun demikian, permintaan pasar kian kompleks, jenis pekerjaan yang mereka kerjakan kian menyusut. Temuannya, penjahit keliling mengalami kesulitan membuat pantalon dengan design baru karena hanya terbiasa untuk memperbaiki. Untuk mengatasi masalah tersebut, sebuah pelatihan pantalon dengan menekankan pada pola, struktur dan volume menawarkan pengembangkan cara berpikir meruang. Hal ini sekaligus mempertanyakan cara berpikir dalam perancangan pakaian yang kerap mengklaim penggunaan ilmu arsitektur sebagai inspirasi saja. Maka dari itu, cara berpikir meruang diterjemahkan melalui pengembangan metode twisting untuk menghasilkan volume pantalon yang dapat dikembangkan untuk menghasilkan perspektif keruangan melalui pecah pola dan penggunaan detail berbeda: misalnya pola – pola rok, sarung, kargo, celana pendek, atau apron . Pola pantalon pada kesempatan ini dikombinasikan untuk menghasilkan kebaruan berupa volume dan kegunaan pantalon untuk keruangan berbeda, sehingga dapat digunakan untuk aktivitas berbeda pula. Teknik twisting pola pantalon jenis pensil dikombinasikan dengan pattern making software berbasis cad, dan dikembangkan sketsanya pada powerpoint presentation. Hasilnya akan menjadi pantalon contoh yang menjadi sebuah kritik atas stagnansi rancangan pantalon di Indonesia.