bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptual effects of fast and automatic visual ensemble statistics from faces in individuals with typical development and autism spectrum conditions
Authors: Chakrabarty Mrinmoy , Wada Makoto 
Published: February 2020

AbstractWe investigated whether covert ensembles of high- (emotion), and low-level (brightness) visual information, extracted from peripheral faces (presentation/encoding:200 ms), unintentionally influences perception of a central target face stimulus in individuals typically developing (TD) and with autism spectrum condition (ASC). Graded alterations in the summary intensities of the emotion and brightness of the peripheral stimuli modulated the perceptions of the target face in both TD and ASC. In contrast, when we measured goal-directed (overt) ensemble face- emotion and brightness perception, we found that in half of ASC the overt ensemble emotion perception was impaired than TD. Additionally, we repeated both experiments with a backward visual mask to restrict not just encoding but also background processing in the visual system to 200 ms. This revealed that the effect of peripheral ensembles on centre perception was present only with brightness at least in TD but of overt ensembles was evident with both emotion and brightness in TD and ASC alike. These results suggest that while ensemble statistics of low-level information derived automatically and rapidly (200 ms) from contextualized faces are used for target face perception, the same takes longer with high-level information. However, overt facial ensembles are rapidly processed in both TD and ASC.
68Ga-PSMA-11 PET/CT in restaging castration-resistant nonmetastatic prostate cancer: detection rate, impact on patients’ disease management and adequacy of impact
Authors: Fourquet Aloÿse , Aveline Cyrielle , Cussenot Olivier , Créhange Gilles , Montravers Françoise , Talbot Jean-Noël , Gauthé Mathieu 
Published: February 2020

AbstractWe aimed to evaluate the impact of prostate-specific membrane antigen ligand labelled with gallium-68 (PSMA-11) PET/CT in restaging patients with castration-resistant nonmetastatic prostate cancer (PCa). Thirty patients were included. At least one malignant focus was found in 27/30 patients (90%). The PSMA-11 PET/CT positivity rate in patients whose prostate-specific antigen serum level (PSA) was greater than 2 ng/ml was 100% (20/20), significantly superior to that of patients whose PSA was less than 2 ng/ml (7/10 = 70%). Six patients (20%) were categorized as oligometastatic (≤3 metastatic foci). Based on the 17 patients for whom a standard of truth was feasible, the overall sensitivity and specificity of PSMA-11 PET/CT in detecting residual disease in castration-resistant PCa patients were 87% and 100% respectively. PSMA-11 PET/CT impacted patients’ disease management in 70% of cases, 60% of case when PSA was less than 2 ng/ml. This management was considered as adequate in 91% of patients. PSMA-11 PET/CT appeared to be effective in restaging patients with castration-resistant nonmetastatic PCa. PSMA-11 PET/CT should be considered as a replacement for bone scans under these conditions.
Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors
Authors: Karda Rajvinder , Rahim Ahad A. , Wong Andrew M. S. , Suff Natalie , Diaz Juan Antinao , Perocheau Dany P. , Tijani Maha , Ng Joanne , Baruteau Julien , Martin Nuria Palomar , Hughes Michael , Delhove Juliette M. K. M. , Counsell John R. , Cooper Jonathan D. , Henckaerts Els , Mckay Tristan R. , Buckley Suzanne M. K. , Waddington Simon N. 
Published: February 2020

AbstractWe have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded this technology to adeno-associated viral vectors. We first explored bio-distribution by assessing GFP expression after neonatal intravenous delivery of AAV8. We observed widespread gene expression in, central and peripheral nervous system, liver, kidney and skeletal muscle. Next, we selected a constitutive SFFV promoter and NFκB binding sequence for bioluminescence and biosensor evaluation. An intravenous injection of AAV8 containing firefly luciferase and eGFP under transcriptional control of either element resulted in strong and persistent widespread luciferase expression. A single dose of LPS-induced a 10-fold increase in luciferase expression in AAV8-NFκB mice and immunohistochemistry revealed GFP expression in cells of astrocytic and neuronal morphology. Importantly, whole-body bioluminescence persisted up to 240 days. We have validated a novel biosensor technology in an AAV system by using an NFκB response element and revealed its potential to monitor signalling pathway in a non-invasive manner in a model of LPS-induced inflammation. This technology complements existing germline-transgenic models and may be applicable to other rodent disease models.
Interference of oleamide with analytical and bioassay results
Authors: Jug Urška , Naumoska Katerina , Metličar Valentina , Schink Anne , Makuc Damjan , Vovk Irena , Plavec Janez , Lucas Kurt 
Published: February 2020

AbstractDuring sample preparation and analysis, samples are coming in contact with different labware materials. By four unrelated analytical (phytochemical and pharmaceutical) case-studies and employing different analytical techniques, we demonstrated the potential misinterpretation of analytical results due to the use of contaminants-leaching labware during sample handling. Oleamide, a common polymer lubricant and a bioactive compound, was identified as a main analytical interference, leaching from different labware items into solvents, recognised as chemically compatible with the tested polymer material. Moreover, anti-inflammatory effect of oleamide at 100 μg mL−1 and considerable pro-inflammatory effect of the plastic syringe extractables (containing oleamide) at the same level were shown in a TLR4-based bioassay. Taking these results into account, together with the fact that oleamide can be a compound of natural origin, we would like to notify the professional public regarding the possible erroneous oleamide-related analytical and bioassay results due to the use of oleamide-leaching labware. Researchers are alerted to double check the real source of oleamide (labware or natural extract), which will prevent further reporting of false results. Analysis of procedural blanks with de-novo developed UHPLC-ESI-MS method is, among some other strategies, proposed for detection of oleamide interference and avoidance of misleading results of certain analyses.
Surface‐enhanced Raman spectroscopy with gold nanoparticle dimers created by sacrificial DNA origami technique
Authors: Yamashita Naoki , Park Seongsu , Kawai Kentaro , Hirai Yoshikazu , Tsuchiya Toshiyuki , Tabata Osamu 
Published: February 2020

In a previously proposed method for molecular detection based on surface‐enhanced Raman spectroscopy (SERS), gold nanoparticle (AuNP) dimers are formed on a substrate using DNA origami with a nanometre‐scale gap between them. In this sacrificial DNA origami technique, a conjugate of two AuNPs and a DNA origami is deposited on a silicon chip, and then the DNA origami is selectively removed using vacuum ultraviolet light and ultrapure water rinsing to form surface‐clean AuNP dimers. The performance of SERS‐based molecular detection of AuNP dimers created using the proposed technique with a 30 nm AuNP diameter has now been evaluated. The Raman signals from the target molecules (4,4′‐bipyridine) were greatly enhanced and thus successfully detected.
Hints on the origins of particle traps in protoplanetary disks given by the Mdust – M⋆ relation
Authors: Pinilla Paola , Pascucci Ilaria , Marino Sebastian 
Published: February 2020

Context. Demographic surveys of protoplanetary disks, carried out mainly with the Atacama Large Millimeter/submillimete Array, have provided access to a large range of disk dust masses (Mdust) around stars with different stellar types and in different star-forming regions. These surveys found a power-law relation between Mdust and M⋆ that steepens in time, but which is also flatter for transition disks (TDs).
Aims. We aim to study the effect of dust evolution in the Mdust−M⋆ relation. In particular, we are interested in investigating the effect of particle traps on this relation.
Methods. We performed dust evolution models, which included perturbations to the gas surface density with different amplitudes to investigate the effect of particle trapping on the Mdust−M⋆ relation. These perturbations were aimed at mimicking pressure bumps that originated from planets. We focused on the effect caused by different stellar and disk masses based on exoplanet statistics that demonstrate a dependence of planet mass on stellar mass and metallicity.
Results. Models of dust evolution can reproduce the observed Mdust−M⋆ relation in different star-forming regions when strong pressure bumps are included and when the disk mass scales with stellar mass (case of Mdisk = 0.05 M⋆ in our models). This result arises from dust trapping and dust growth beyond centimeter-sized grains inside pressure bumps. However, the flatter relation of Mdust − M⋆ for TDs and disks with substructures cannot be reproduced by the models unless the formation of boulders is inhibited inside pressure bumps.
Conclusions. In the context of pressure bumps originating from planets, our results agree with current exoplanet statistics on giant planet occurrence increasing with stellar mass, but we cannot draw a conclusion about the type of planets needed in the case of low-mass stars. This is attributed to the fact that for M⋆ < 1 M⊙, the observed Mdust obtained from models is very low due to the efficient growth of dust particles beyond centimeter-sizes inside pressure bumps.
Significance of Extra-Esophageal Symptoms in Pediatric Gastroesophageal Reflux Disease
Authors: Košec Andro , Žaja Orjena , Matovinović Filip , Jelavić Boris , Baudoin Tomislav 
Published: February 2020

Abstract
Introduction Current practice guidelines in gastroesophageal reflux disease (GERD) often require invasive diagnostic testing.
Objective The aim of the present study was to evaluate the significance of extra-esophageal symptoms and reliability of a screening risk score that is simple to use.
Methods A longitudinal retrospective single-institution cohort study. Setting: A university clinical hospital tertiary referral center. The present study enrolled pediatric patients with symptoms suggestive of GERD: epigastric pain, occasional nausea, regurgitation, tasting acid in the oral cavity, chronic cough, hoarseness of voice, frequent throat clearing. The patients underwent 24-hour esophageal pH monitoring and fiber-optic laryngoscopy. The correlations between the local findings, anamnestic and objective measurement data were analyzed.
Results The present study evaluated 89 pediatric patients. Patients with asthma presented significantly more often with adjoining gastrointestinal symptoms (p = 0.0472). Patients that were obese were linked to a higher rate of reports of gastrointestinal symptoms (p = 0.0495). After the patients had been assigned to newly developed risk groups, obesity showed to be significantly more frequent in patients placed in higher risk groups (p < 0.0001) for a positive GERD diagnosis.
Conclusion Patients with leading symptoms of asthma presented significantly more often with adjoining gastrointestinal symptoms. Obesity showed to be significantly more frequent in patients placed in higher risk groups for a positive GERD diagnosis.
Knowledge and Opinions of Saudi Dentists Regarding Dental Treatment of Patients Undergoing Bisphosphonates
Authors: Al-Maweri Sadeq Ali , Alshammari Maha Naif , Alharbi Abdulaziz Rabah , Bahein Aisha Abdullah , Alhajj Mohammed Nasser , Al-Shamiri Hashem Motahir , Alahmary Ahmed Wallan , Doumani Mazen 
Published: February 2020

Abstract

Objectives Bisphosphonates (BPs) are used for treatment of various benign and malignant medical conditions. Medications-related osteonecrosis of the jaws (MRONJ) is a very serious complication of prolonged therapy with BPs. This study aimed to assess the level of knowledge among dental professionals in Saudi Arabia regarding MRONJ.
Materials and Methods This was a questionnaire-based, cross-sectional study. A self-administered questionnaire comprising close-ended questions about BPs and MRONJ was sent to a convenience sample of dentists in Saudi Arabia.Statistical Analysis SPSS software was used for data analysis. Chi-square test was used to compare between the groups. The significance level was set at p < 0.05.
Results A total of 607 dentists participated in this survey. Overall, the respondents showed insufficient level of knowledge regarding BPORNJ, with only 70% of the respondents had heard about BPORNJ, and less than 50% recognized the risk factors and clinical features of the disease. Additionally, while two-thirds of the respondents recognized the importance of taking BPs history, the majority did not know the correct treatment approach. Respondents with higher degrees (specialists) showed far better knowledge than general dentists.
Conclusion The knowledge regarding BPs therapy and its complications among Saudi dentists is unsatisfactory. Hence, interventions are highly required to improve dentists’ knowledge regarding BPs and MRONJ.
(Im)politeness, morality and the internet
Authors: Xie Chaoqun 
Published: February 2020

Abstract
Much recent research has contributed to the emergence of a moral turn in (im)politeness scholarship, further confirming the
evaluative nature of (im)politeness and the moral basis of (im)politeness evaluations, and further illuminating, among other
things, what is really at work when (im)politeness evaluations take place, what the moral order consists of and how the moral
order influences (im)politeness evaluations. Meanwhile, thanks to much emphasis on the instrumentality of words and
utterances, a distinction can be discerned between ‘politeness without’ (or practical politeness) and ‘politeness within’ (or
true politeness). Politeness within is true and truthful, but politeness without is not necessarily so. True politeness may be
in when self is out. This volume aims to further foreground the link between (im)politeness and morality in people’s
online interactions, revealing something about ourselves and about our life-worlds.
Feedback between drought and deforestation in the Amazon
Authors: Staal Arie , Flores Bernardo M , Aguiar Ana Paula D , Bosmans Joyce H C , Fetzer Ingo , Tuinenburg Obbe A 
Published: February 2020

Abstract
Deforestation and drought are among the greatest environmental pressures on the Amazon rainforest, possibly destabilizing the forest-climate system. Deforestation in the Amazon reduces rainfall regionally, while this deforestation itself has been reported to be facilitated by droughts. Here we quantify the interactions between drought and deforestation spatially across the Amazon during the early 21st century. First, we relate observed fluctuations in deforestation rates to dry-season intensity; second, we determine the effect of conversion of forest to cropland on evapotranspiration; and third, we simulate the subsequent downwind reductions in rainfall due to decreased atmospheric water input. We find large variability in the response of deforestation to dry-season intensity, with a significant but small average increase in deforestation rates with a more intense dry season: with every mm of water deficit, deforestation tends to increase by 0.13% per year. Deforestation, in turn, has caused an estimated 4% of the recent observed drying, with the south-western part of the Amazon being most strongly affected. Combining both effects, we quantify a reinforcing drought-deforestation feedback that is currently small, but becomes gradually stronger with cumulative deforestation. Our results suggest that global climate change, not deforestation, is the main driver of recent drying in the Amazon. However, a feedback between drought and deforestation implies that increases in either of them will impede efforts to curb both.
Post-Brexit implications for transboundary groundwater management along the Northern Ireland and the Republic of Ireland border
Authors: Fraser C M , Brickell J , Kalin R M 
Published: February 2020

Abstract
There are multiple transboundary groundwater bodies shared between Northern Ireland and the Republic of Ireland that are currently managed jointly through the EU Water Framework Directive. In 2016 the United Kingdom voted to leave the European Union and consequently, there are uncertainties regarding the future status of groundwater management between Northern Ireland and the Republic of Ireland in regards to future UK environmental policy. This paper explores the post ‘Brexit’ transboundary groundwater implications, if a transboundary groundwater agreement is required between Northern Ireland and the Republic of Ireland, and, should it transpire, what form should it take.
Urban river governance through community movement to increase the adaptive capacity to climate change of the poor: a case study of Yogyakarta
Authors: Wicaksono Andie A. 
Published: February 2020

Abstract
This paper explains how the community movement governed the urban rivers’ climate adaptation using the case of Yogyakarta’s three main rivers. Before, these areas were prone to floods and disease outbreak. The Sultan Ground and private owned land statuses by the riversides created difficulties since many urban poor in this city lived in these areas. The local authority supported the poor through community engagement. This scheme resulted in a breakthrough. The communities there became more aware of the misuse of rivers. They proactively participated in the discussions and initiated a movement to conserve the riverside areas. The urban river governance proceeded both bottom-up and top-down approaches. This case used the explanation with purposive sampling derived from a list of related informants. The primary data was acquired through snowballing interviews, while secondary data was obtained from related stakeholders’ archives. Both types of data were collected to understand the multilevel governance structure within the stakeholders’ collaboration context. The movement resulted in better city planning. It reduced the vulnerability of the poor, while increasing their adaptive capacity to climate change. Using Yogyakarta as a case, this paper adds to the knowledge of urban resilience strategy in developing countries.
Importance of tangible and intangible heritage of the core area of Chowk, Lucknow
Authors: Kapur Arun 
Published: February 2020

Abstract
The tangible and intangible heritage of a country in a mélange of epitome created during various phases of history. The heritage core city areas of many South Asian countries are losing their original identity because of the rampant globalization and modern development. The conservation and preservation policies of such heritage core city areas need attention towards its holistic integration with urban development practices which can bridge a gap between the old and the new developments of the cities. Almost all the heritage core city areas have historical, religious, social, cultural, spiritual, and scientific or aesthetic significance. There is multiple layer of historical importance which give unique identification of heritage built up areas. The built-up heritage of the core areas is based on the typology of buildings, historical importance, architectural character in terms of plan and ornamentation, the socio-cultural lifestyle of people, economy, geographical location, governance, etc. This paper is an abstract from the research work of the author, where there is an attempt to discuss the way in which conservation is integrated with the urban development and in turn its possible contribution to the urban development of core city area of Chowk, Lucknow. The paper concluded with establishing a relationship between the tangible and intangible assets of the heritage of the core area of Chowk, Lucknow. It proposes a methodology towards conserving the cultural heritage of Chowk in today’s context.
Design positions of waste utility system that shaped the human movement patterns in traditional markets
Authors: Nadya Tengku , Dewi Ova Candra 
Published: February 2020

Abstract
Not every traditional market is equipped with sufficient waste processing utility system. The waste treatment system in Indonesia consists of five stages that include: (1) storage, (2) collection, (3) transfer, (4) transportation and (5) disposal system. Each stage involves a storage container with various capacities and different movement patterns for each processing system. Currently, merchants determine the storage placements and processing paths that depend on the market management. In general, they place them freely, not only in their stand but also in circulation space which then affected the human movement. A set of data collection, observation, and mapping were carried out in two traditional markets in Jakarta and three traditional markets in Depok. This study was aimed to identify the human movement patterns with regards to the positions of the utility system. Findings revealed two factors that influenced the human movement. Those were the availability of space in advance (the compatibility between spaces and properties of the containers), and the circulation paths (the process of waste treatment at the circulation paths that influenced human movement at certain times).
A study of cisadane riverside on riverbank development towards urban sustainability
Authors: Apriliani Dian , Dewi Ova Candra 
Published: February 2020

Abstract
Rivers have immense benefits for the environment and community. They become one of the water resources for the community and an option for community recreation area. Rivers also provide habitat and balance the ecosystem for the environment. Currently, the community is neglecting many rivers in that their water becomes polluted and unusable. This is the reason behind the existence of riverbank development, including in Cisadane Riverside located in Tangerang, Indonesia. This study was carried out in Cisadane Riverside to observe and analyse the elements that constructed the riverbank as public facilities toward sustainable pillars: environment, social and economy for urban sustainability. Observation and interview were conducted in six zones along the Cisadane Riverside. Regarding the riverbank development, it is important to pay attention to the environmental aspect to maintain the urban ecology while achieving the social and economic aspects. In conclusion, the riverbank development that considered the integrated environment, social and economic aspects would create the activity and interaction space for supporting both the urban sustainability particularly for the riverbank itself. The result of this study would be used as the reference for riverfront development towards urban sustainability in Indonesia.