bluuebunny/crossref_metadata_2025_split huggingface dataset:
The highly interrelated GHRH, p53, and Hsp90 universe
Authors: Barabutis Nektarios , Siejka Agnieszka 
Published: April 2020

Abstractp53 universe is composed of a complex regulatory network, destined to counteract multifarious challenges threatening cell survival. Imbalance in those responses may result in human disease associated with inevitable consequences. The present work delivers our view of the corresponding phenomena, by involving the endothelium defender in meticulously orchestrated events against inflammatory stimuli. Immersing into the great depths of p53 cosmos may lead to promising therapies against devastating disorders, including acute respiratory distress syndrome.
Mineral and fatty acid contents of maize kernels with different levels of polyembryony
Authors: Michel‐Michel Mariela R. , Aguilar‐Zárate Pedro , Lopez‐Badillo Claudia M. , Chávez‐González Mónica L. , Flores‐Gallegos Adriana C. , Espinoza‐Velázquez José , Aguilar Cristóbal N. , Rodríguez‐Herrera Raúl 
Published: April 2020

AbstractBackground and objectivesMaize (Zea mays) is a cereal of great commercial importance around the world. It has been reported that maize presents polyembryony (PE), which is described as the appearance of two or more seedlings from a germinated seed. Minerals and fatty acids (FA) play important roles in the growth and development of plants and animals. The objective of this work was to determine the minerals and FA content in embryo and endosperm of 32 maize genotypes kernels with different levels of PE (high [NAP], low [NBP], and nonpolyembryonic [T]).FindingsThe polyembryonic genotypes showed higher concentrations of calcium, magnesium, phosphorous, and potassium. In this study, magnesium was only found in the embryo, while in the embryo of NAP genotypes were found the highest content of K (1,834 mg/kg) and P (656 mg/kg). In contrast, the highest amount of Mg (216 mg/kg) was found in the embryo of NBP genotypes. On the other hand, the highest Ca (251 mg/kg) content was found in the endosperm of NAP genotypes. The highest oil content was observed in NBP‐9‐EM genotype grains with 50.2%, while the highest percentage of oleic (29.10%) and linoleic acid (63.21%) was found in kernels of the NAP‐6‐EM genotype.ConclusionsThe polyembryonic maize has high mineral content, and some of them have been associated with the human diet; in addition, in these genotypes, high oil content (with the presence of essential FA) was observed.Significance and noveltyThese results are important because polyembryonic maize kernel may be an alternative for adequate nutrient and essential oils intake. In addition, to the better agronomic characteristics offered by polyembryonic maize genotypes, which may imply a greater income for maize producers.
Maxillofacial gunshot injures and their therapeutic challenges: Case series
Authors: Momeni Roochi Mehrnoush , Razmara Farnoosh 
Published: April 2020

AbstractMaxillofacial gunshot injuries require proficiency to determine a suitable treatment plan and surgical intervention. In this paper, present 4 gunshot cases. Treatment in these patients is very challenging. Moreover, post‐treatment infections are a serious problem in such cases. Thus, step‐by‐step surgery is essential to obtain a better result in these patients.
Latent distant metastasis of renal cell carcinoma to skin: A case report
Authors: Singh Pretty , Somani Kavita 
Published: April 2020

AbstractRenal cell carcinoma (RCC) is known to recur decades after nephrectomy; however, isolated cutaneous metastasis is rare. Previous clinical history plays vital role. Newly occurring skin lesions in follow‐through patients of RCC should be carefully evaluated, and possibility of its metastasis should be acknowledged. Disease‐free survival postmetastasectomy is possible.
Syringopleural shunt placement in a pug with a cervical spinal diverticulum and associated syringomyelia
Authors: Tauro Anna , Rusbridge Clare 
Published: April 2020

AbstractWe report persistence of associated syringomyelia and formation of newly caudal spinal arachnoid diverticulum, following marsupialization surgery. We describe syringopleural shunt placement as a novel approach to treat both conditions in a Pug dog.
In situ Activation of Bimetallic Pd−Pt Methane Oxidation Catalysts
Authors: Karinshak Kyle A. , Lott Patrick , Harold Michael P. , Deutschmann Olaf 
Published: April 2020

AbstractThis study investigates possible pathways to reduce water inhibition over Pd−Pt methane oxidation catalysts supported on alumina and a ceria‐zirconia mixed oxide under conditions typical for lean burn gas engines. Spatially resolved concentration and temperature profiles reveal that addition of hydrogen to the lean reaction mixture leads to significant heat production and an increase in methane conversion. Moreover, reductive pulses during operation are not only able to regenerate the catalyst deactivated by water by removal of OH‐groups from the catalyst surface, but even promote its activity after repeated application of pulsing for several hours. X‐ray absorption spectroscopy reveals the formation of a partially reduced PdO−Pd mixture during the pulsing, which explains the increase in activity. This state of high activity is stable for several hours under the tested lean conditions. The results presented in this study suggest an efficient in situ activation strategy to overcome water inhibition of methane total oxidation over Pd−Pt catalysts by careful process control.
Selective Detection of Cysteine at a Mesoporous Silica Film Electrode Functionalized with Ferrocene in the Presence of Glutathione
Authors: Maheshwari Himanshu , Vilà Neus , Herzog Grégoire , Walcarius Alain 
Published: April 2020

AbstractUnmodified and ferrocene‐functionalized mesoporous silica layers exhibiting vertical nanochannels have been grown through electrochemically assisted self‐assembly onto indium‐tin oxide (ITO), and the resulting film electrodes have been applied for the electrochemical detection of cysteine. When using the unmodified film electrode and ferrocenedimethanol (Fc(MeOH)2) as a mediator in solution, both cysteine and glutathione can be oxidized by the Fc(MeOH)2+ generated at the electrode surface, but the electron transfer rates were three times faster with cysteine than with glutathione. This can be exploited for the reagent‐free selective detection of cysteine over glutathione by using a ferrocene‐functionalized mesoporous silica film on an ITO electrode, based on a combination of charge transfer kinetic and mass transport limitations through the oriented nanochannels. This has been demonstrated here by using cyclic voltammetry and amperometry in flow‐injection analysis mode. A sensitivity of 1.28 mA M−1 was measured for the cysteine concentration range of 3–20 μM with a repeatability of the signal between 3 and 12 %. The lowest concentration of cysteine experimentally detected was 3 μM.
Early Relaxation Dynamics in the Photoswitchable Complex trans‐[RuCl(NO)(py)4]2+
Authors: Talotta Francesco , Boggio‐Pasqua Martial , González Leticia 
Published: April 2020

AbstractThe design of photoswitchable transition metal complexes with tailored properties is one of the most important challenges in chemistry. Studies explaining the underlying mechanisms are, however, scarce. Herein, the early relaxation dynamics towards NO photoisomerization in trans‐[RuCl(NO)(py)4]2+ is elucidated by means of non‐adiabatic dynamics, which provided time‐resolved information and branching ratios. Three deactivation mechanisms (I, II, III) in the ratio 3:2:4 were identified. Pathways I and III involve ultrafast intersystem crossing and internal conversion, whereas pathway II involves only internal conversion.
Static job scheduling for environments with vertical elasticity
Authors: Kloh Henrique , Rebello Vinod E. F. , Boeres Cristina , Schulze Bruno , Ferro Mariza 
Published: April 2020

SummaryIn virtualized environments, such as Clouds, allocating a fixed amount of resources to a job a priori, may result in underutilization of the shared host. Meanwhile, vertical elasticity can be adopted to reduce the impact by resizing virtual machines (VMs) dynamically, in conjunction with suspension and/or migration before the host had been overloaded. In order to reduce the number of such events, but still avoid overloading the host, it is important to find an effective initial VM allocation. To achieve this, the scheduler must work in unison with the local host elasticity controllers to reduce interference. This work proposes and evaluates a framework for job scheduling in elastic memory managed virtualized environments. The memory elasticity management in clouds (MEMiC) framework is a two‐tier VM scheduler for batch jobs which attempts to predict the impact caused by competition for the memory of a host in shared Cloud‐like environments for harnessing VM allocation, suspension, and migration. Evaluations show that the MEMiC achieves a reduction of approximately 19% in the total time for jobs execution in comparison to other approaches, by reducing the degree of interference.
Screening Assay Protocols Targeting the Nav1.7 Channel Using Qube High‐Throughput Automated Patch‐Clamp System
Authors: Qian Binbin , Park Sung Hoon , Yu Weifeng 
Published: April 2020

AbstractThis article describes the basic procedure for setting up the screening protocol and recording data for Nav1.7 on a Qube automated patch‐clamp system. Three protocols along with step‐by‐step details are provided. First, we describe a protocol to estimate Vhalf, the voltage at which half of the channels are inactivated, using traditional steady‐state inactivation measurement as well as a new adaptive online estimation. Second, we establish a state‐dependent protocol using adaptive online Vhalf measurement to obtain a concentration response curve (CRC) on known reference blockers. Last, we introduce a use‐dependent protocol. In our hands, the sample reference demonstrated good state‐ and use‐dependent inhibition of Nav1.7. © 2020 by John Wiley & Sons, Inc.Basic Protocol 1: Comparing Vhalf measurements using offline calculation and a new adaptive online estimationBasic Protocol 2: Concentration response experiments using a state‐dependent protocolBasic Protocol 3: Concentration response experiments using a use‐dependent protocolSupport Protocol: Cell culture protocol
Photo/Bio‐Electrochemical Systems for Environmental Remediation and Energy Harvesting
Authors: Yang Fan , Ke Zunjian , Li Zhida , Patrick Margaret , Abboud Zeinab , Yamamoto Nobuyuki , Xiao Xiangheng , Gu Jing 
Published: April 2020

AbstractWater and energy systems are interdependent: water is utilized in each stage of energy production, and energy is required to extract, treat, and deliver water for many uses. However, energy and water systems are usually developed and managed independently. In the quest to develop environmentally friendly and energy‐efficient solutions for water and energy issues, photoelectrochemical (PEC) energy conversion and microbial electrochemical (MEC) systems show profound potential for addressing environmental remediation problems and harvesting energy simultaneously. Herein, PEC, MEC, and their variant hybrid systems toward energy conversion and environmental remediation are summarized and discussed.
Efficient power management circuit for biomass‐based energy harvesting system
Authors: Umaz Ridvan 
Published: April 2020

SummaryThis paper presents an efficient power management circuit (PMC) for microbial fuel cells (MFCs). The proposed PMC has been designed with off‐the‐shelf components including a charge pump, a supercapacitor, and two boost converters. Both the charge pump and one of the boost converter are directly connected to the MFC, that is, connected in parallel to the MFC. The reason for that using the charge pump can extend the variety of PMC input power, and deploying the boost converter can extract more power from the MFC. Thus, the proposed PMC can test the input power range from 11.25 μW to 1.6 mW. Also, the proposed PMC can extract 6× higher power from the MFC as compared with the charge pump alone. A wide dynamic load range from 10.89 μW to 108.9 mW can be supported by the proposed PMC. Measured results show that the interval to provide power supply to the load by the proposed PMC is 9.2× shorter than that achieved by the charge pump alone. Also, the proposed PMC enhances the end‐to‐end efficiency by range from 10× to 14.35× with varying loads. The proposed PMC achieves the end‐to‐end peak efficiency of 73.185%. The proposed PMC can achieve a low charging time, a wide dynamic load range, and a regulated output voltage compared with prior works.
Network traffic prediction method based on wavelet transform and multiple models fusion
Authors: Tian Zhongda 
Published: April 2020

SummaryAccurate prediction of network traffic is an important premise in network management and congestion control. In order to improve the prediction accuracy of network traffic, a prediction method based on wavelet transform and multiple models fusion is presented. Mallat wavelet transform algorithm is used to decompose and reconstruct the network traffic time series. The approximate and detailed components of the original network traffic can be obtained. The characteristics of approximate components and detail components are analyzed by Hurst exponent. Then, according to the different characteristics of the components, autoregressive integrated moving average model (ARIMA) is chosen as the prediction model for the approximate component. Least squares support vector machine (LSSVM) is used to predict detail component. Meanwhile, an improved particle swarm optimization (PSO) algorithm is proposed to optimize the parameters of the LSSVM model. Gauss‐Markov estimation algorithm is adapted to fuse the predicted values of multiple prediction models. The variance of fusion prediction error is smaller than that of single prediction model, and the prediction accuracy is improved. Two actual datasets of network traffic are studied. Compared with other state‐of‐the‐art models, the case study results indicate that the proposed prediction method has a better prediction effect.
Joint backhaul bandwidth and power allocation in heterogeneous cellular networks: A two‐level approach
Authors: Zheng Handan , Li Li 
Published: April 2020

SummaryWe investigate the problem of joint downlink wireless backhaul bandwidth (WBB) and power allocation in heterogeneous cellular networks (HCNs). A WBB partitioning scheme is considered, which allocates the whole bandwidth between the macrocell and small cells for data transmission and backhauling. We formulate an optimization problem to maximize the weighted sum logarithmic utility function by jointly optimizing WBB portion and fronthaul power allocation of each base station with consideration of the backhaul capacity limitation on each small cell. In order to solve this joint optimization problem, we propose a hierarchical two‐level approach and decompose the original problem into two independent subproblems: the WBB allocation at the macrocell base station (MBS) and the power allocation at both the MBS and small cell base stations (SBSs). Accordingly, the optimal WBB portion and power allocation solutions are obtained, respectively. Furthermore, we develop a distributed algorithm to implement the joint WBB and power allocation. Numerical results verify the effectiveness of the proposed approach and analyze the impact of the weighted coefficient and backhaul capacity limitation on the network performance. In addition, significant performance gains can be achieved by the proposed approach over the benchmark.
Schwann cell interactions during the development of the peripheral nervous system
Authors: Wilson Emma R. , Della‐Flora Nunes Gustavo , Weaver Michael R. , Frick Luciana R. , Feltri M. Laura 
Published: April 2020

AbstractSchwann cells play a critical role in the development of the peripheral nervous system (PNS), establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cell interactions integral to the proper establishment, spatial arrangement, and function of the PNS. We include signals that cascade onto Schwann cells from axons and from the extracellular matrix, bidirectional signals that help to establish the axo‐glial relationship and how Schwann cells in turn support the axon. Further, we speculate on how Schwann cell interactions with other components of the developing PNS ultimately promote the complete construction of the peripheral nerve.
Eating Disorder Examination – Questionnaire short forms: A comparison
Authors: Machado Paulo P. P. , Grilo Carlos M. , Rodrigues Tânia F. , Vaz Ana R. , Crosby Ross D. 
Published: April 2020

AbstractObjectiveThe Eating Disorder Examination – Questionnaire (EDE‐Q) is a widely used self‐report measure of eating‐disordered behaviors and attitudes. Recent studies utilizing confirmatory factor analyses (CFA) have proposed alternative and shorter forms. The aim of this study was to compare the full‐length version of the EDE‐Q and several proposed short forms (7‐item, 8‐item, and 18‐item) in terms of their psychometric properties, including concurrent, convergent and discriminant validity, factor structure, and sensitivity to change.MethodsParticipants from two eating‐disorder clinical samples (N = 175 and 38) and from a nonclinical sample (N = 3,413) completed a battery of measures, including the Portuguese version of the EDE‐Q. Analyses compared psychometric properties of the available short forms of the EDE‐Q among each other.ResultsAll forms of the EDE‐Q showed good internal consistency values, correlated highly among each other (r > .90) and with different measures of eating psychopathology (r > .80). All EDE‐Q forms were able to distinguish between cases and controls with moderate‐to‐high accuracy and were sensitive to change. CFA failed to support the proposed factor structure for all the EDE‐Q forms, except for the 7‐item form.DiscussionThe present study provides empirical background for choosing between different forms of the EDE‐Q. Findings indicate that for nonclinical and for clinical research, including studies of treatment change and outcome, the short forms of the EDE‐Q can be used. A shorter version is a viable alternative when less time‐consuming alternatives are needed, such to quickly screen for eating‐disorder psychopathology or to perform session‐by‐session treatment monitoring.
Wolbachia affect behavior and possibly reproductive compatibility but not thermoresistance, fecundity, and morphology in a novel transinfected host, Drosophila nigrosparsa
Authors: Detcharoen Matsapume , Arthofer Wolfgang , Jiggins Francis M. , Steiner Florian M. , Schlick‐Steiner Birgit C. 
Published: April 2020

AbstractWolbachia, intracellular endosymbionts, are estimated to infect about half of all arthropod species. These bacteria manipulate their hosts in various ways for their maximum benefits. The rising global temperature may accelerate species migration, and thus, horizontal transfer of Wolbachia may occur across species previously not in contact. We transinfected and then cured the alpine fly Drosophila nigrosparsa with Wolbachia strain wMel to study its effects on this species. We found low Wolbachia titer, possibly cytoplasmic incompatibility, and an increase in locomotion of both infected larvae and adults compared with cured ones. However, no change in fecundity, no impact on heat and cold tolerance, and no change in wing morphology were observed. Although Wolbachia increased locomotor activities in this species, we conclude that D. nigrosparsa may not benefit from the infection. Still, D. nigrosparsa can serve as a host for Wolbachia because vertical transmission is possible but may not be as high as in the native host of wMel, Drosophila melanogaster.
What smells? Developing in‐field methods to characterize the chemical composition of wild mammalian scent cues
Authors: Thompson Cynthia L. , Bottenberg Kimberly N. , Lantz Andrew W. , de Oliveira Maria A. B. , Melo Leonardo C. O. , Vinyard Christopher J. 
Published: April 2020

AbstractOlfactory cues play an important role in mammalian biology, but have been challenging to assess in the field. Current methods pose problematic issues with sample storage and transportation, limiting our ability to connect chemical variation in scents with relevant ecological and behavioral contexts. Real‐time, in‐field analysis via portable gas chromatography–mass spectrometry (GC‐MS) has the potential to overcome these issues, but with trade‐offs of reduced sensitivity and compound mass range. We field‐tested the ability of portable GC‐MS to support two representative applications of chemical ecology research with a wild arboreal primate, common marmoset monkeys (Callithrix jacchus). We developed methods to (a) evaluate the chemical composition of marmoset scent marks deposited at feeding sites and (b) characterize the scent profiles of exudates eaten by marmosets. We successfully collected marmoset scent marks across several canopy heights, with the portable GC‐MS detecting known components of marmoset glandular secretions and differentiating these from in‐field controls. Likewise, variation in the chemical profile of scent marks demonstrated a significant correlation with marmoset feeding behavior, indicating these scents’ biological relevance. The portable GC‐MS also delineated species‐specific olfactory signatures of exudates fed on by marmosets. Despite the trade‐offs, portable GC‐MS represents a viable option for characterizing olfactory compounds used by wild mammals, yielding biologically relevant data. While the decision to adopt portable GC‐MS will likely depend on site‐ and project‐specific needs, our ability to conduct two example applications under relatively challenging field conditions bodes well for the versatility of in‐field GC‐MS.
Accounting for space and uncertainty in real‐time location system‐derived contact networks
Authors: Farthing Trevor S. , Dawson Daniel E. , Sanderson Michael W. , Lanzas Cristina 
Published: April 2020

Abstract

Point data obtained from real‐time location systems (RTLSs) can be processed into animal contact networks, describing instances of interaction between tracked individuals. Proximity‐based definitions of interanimal “contact,” however, may be inadequate for describing epidemiologically and sociologically relevant interactions involving body parts or other physical spaces relatively far from tracking devices. This weakness can be overcome by using polygons, rather than points, to represent tracked individuals and defining “contact” as polygon intersections.

We present novel procedures for deriving polygons from RTLS point data while maintaining distances and orientations associated with individuals' relocation events. We demonstrate the versatility of this methodology for network modeling using two contact network creation examples, wherein we use this procedure to create (a) interanimal physical contact networks and (b) a visual contact network. Additionally, in creating our networks, we establish another procedure to adjust definitions of “contact” to account for RTLS positional accuracy, ensuring all true contacts are likely captured and represented in our networks.

Using the methods described herein and the associated R package we have developed, called contact, researchers can derive polygons from RTLS points. Furthermore, we show that these polygons are highly versatile for contact network creation and can be used to answer a wide variety of epidemiological, ethological, and sociological research questions.

By introducing these methodologies and providing the means to easily apply them through the contact R package, we hope to vastly improve network‐model realism and researchers' ability to draw inferences from RTLS data.