bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of N-Acetylcysteine on Autologous Fat Graft: First-in-Human Pilot Study
Authors: Pietruski Piotr , Paskal Wiktor , Paluch Łukasz , Paskal Adriana M. , Nitek Żaneta , Włodarski Paweł , Walecki Jerzy , Noszczyk Bartłomiej 
Published: March 2020

Abstract
Background
Our goal was to determine whether N-acetylcysteine (NAC) administered to the tumescent solution can reduce oxidative stress and increase autologous fat graft (AFG) viability.

Methods
The study included 15 women with a mean age of 31.8 years (range 23–39 years) who underwent breast asymmetry correction with AFG harvested from both thighs. One thigh was infiltrated with a standard tumescent fluid (control graft) and other with a NAC-enriched tumescent fluid (NAC-treated graft). Each participant had breast MRI imaging before and 6 months after the procedure. Also, adipose tissue samples from each graft were subjected to biochemical analysis, flow cytometric assay and qRT-PCR to determine the markers of oxidative stress, angiogenesis and adipogenesis.

Results
Concentration and activity of superoxide dismutase in the NAC-treated grafts turned out to be significantly higher than in the control grafts, in both fresh (p = 0.041 and p = 0.023, respectively) and frozen samples (p = 0.004 and p = 0.003, respectively). The level of nitric oxide in frozen samples from the control grafts was significantly higher than in the NAC-treated grafts (p = 0.009). iNOS was the only qRT-PCR target showing significant intergroup differences, with higher transcription levels observed in the control grafts (p = 0.027). Breast volumetric analysis demonstrated that the NAC-treated group had a 12.19% lower resorption rate than the control group, although it was found to be statistically insignificant (p = 0.149). No postoperative complications were observed during a 6-month follow-up.

Conclusions
Some results of this study are promising. Further studies on larger groups are needed to determine NAC impact on AFG.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Trial registry name
The Impact of N-Acetylcysteine on Volumetric Retention of Autologous Fat Graft for Breast Asymmetry Correction.

Registration identification number
NCT03197103.

URL for the registry
https://clinicaltrials.gov/ct2/show/NCT03197103?term=acetylcysteine&amp;rank=6
Fronto-orbital advancement and reconstruction using reverse frontal bone graft without the use of orbital bar: a technical note
Authors: Robins James M. W. , Sheikh Asim J. , Shastin Dmitri , Schramm Moritz W. J. , Carter Paula , Russell John L. , Liddington Mark , Chumas Paul D. 
Published: March 2020

AbstractIntroductionWe describe our technique of using reverse frontal bone graft for FOAR for patients with metopic or coronal synostosis and present our complications using the Leeds classification system for complications in craniosynostosis surgery.MethodsSince April 2015, seventeen patients have been operated using this technique. We perform a frontal bone graft that is then reversed, and supraorbital margins are drilled out. The orbital bar is then removed and drilled down to make bone dust and on-lay bone grafts which are then used to fill gaps on exposed dura and fill in around the temporal region.ResultsAll 17 patients who underwent this technique have good cosmetic results. We report 5 (29%) complications and 8 (47%) blood transfusions (7 exposures, 1 cell salvage).
Seasonal to decadal predictions of regional Arctic sea ice by assimilating sea surface temperature in the Norwegian Climate Prediction Model
Authors: Dai Panxi , Gao Yongqi , Counillon François , Wang Yiguo , Kimmritz Madlen , Langehaug Helene R. 
Published: March 2020

AbstractThe version of the Norwegian Climate Prediction Model (NorCPM) that only assimilates sea surface temperature (SST) with the Ensemble Kalman Filter has been used to investigate the seasonal to decadal prediction skill of regional Arctic sea ice extent (SIE). Based on a suite of NorCPM retrospective forecasts, we show that seasonal prediction of pan-Arctic SIE is skillful at lead times up to 12 months, which outperforms the anomaly persistence forecast. The SIE skill varies seasonally and regionally. Among the five Arctic marginal seas, the Barents Sea has the highest SIE prediction skill, which is up to 10–11 lead months for winter target months. In the Barents Sea, the skill during summer is largely controlled by the variability of solar heat flux and the skill during winter is mostly constrained by the upper ocean heat content/SST and also related to the heat transport through the Barents Sea Opening. Compared with several state-of-the-art dynamical prediction systems, NorCPM has comparable regional SIE skill in winter due to the improved upper ocean heat content. The relatively low skill of summer SIE in NorCPM suggests that SST anomalies are not sufficient to constrain summer SIE variability and further assimilation of sea ice thickness or atmospheric data is expected to increase the skill.
The intracellular domain of BP180/collagen XVII is intrinsically disordered and partially folds in an anionic membrane lipid-mimicking environment
Authors: Tuusa Jussi , Koski M. Kristian , Ruskamo Salla , Tasanen Kaisa 
Published: March 2020

AbstractThe trimeric transmembrane collagen BP180, also known as collagen XVII, is an essential component of hemidesmosomes at the dermal–epidermal junction and connects the cytoplasmic keratin network to the extracellular basement membrane. Dysfunction of BP180 caused by mutations in patients with junctional epidermolysis bullosa or autoantibodies in those with bullous pemphigoid leads to severe skin blistering. The extracellular collagenous domain of BP180 participates in the protein’s triple-helical folding, but the structure and functional importance of the intracellular domain (ICD) of BP180 are largely unknown. In the present study, we purified and characterized human BP180 ICD. When expressed in Escherichia coli as glutathione-S-transferase or 6 × histidine tagged fusion protein, the BP180 ICD was found to exist as a monomer. Analysis of the secondary structure content by circular dichroism spectroscopy revealed that the domain is intrinsically disordered. This finding aligned with that of a bioinformatic analysis, which predicted a disordered structure. Interestingly, both anionic detergent micelles and lipid vesicles induced partial folding of the BP180 ICD, suggesting that in its natural environment, the domain’s folding and unfolding may be regulated by interaction with the cell membrane or accompanying proteins. We hypothesize that the intrinsically disordered structure of the ICD of BP180 contributes to the mechanism that allows the remodeling of hemidesmosome assembly.
Message randomization and strong security in quantum stabilizer-based secret sharing for classical secrets
Authors: Matsumoto Ryutaroh 
Published: March 2020

AbstractWe improve the flexibility in designing access structures of quantum stabilizer-based secret sharing schemes for classical secrets, by introducing message randomization in their encoding procedures. We generalize the Gilbert–Varshamov bound for deterministic encoding to randomized encoding of classical secrets. We also provide an explicit example of a ramp secret sharing scheme with which multiple symbols in its classical secret are revealed to an intermediate set, and justify the necessity of incorporating strong security criterion of conventional secret sharing. Finally, we propose an explicit construction of strongly secure ramp secret sharing scheme by quantum stabilizers, which can support twice as large classical secrets as the McEliece–Sarwate strongly secure ramp secret sharing scheme of the same share size and the access structure.
The Existence Value of a Distinctive Native American Culture: Survival of the Hopi Reservation
Authors: Carson Richard T. , Hanemann W. Michael , Whittington Dale 
Published: March 2020

AbstractWe measure the value placed by the American public on ensuring the continued existence of the traditional Hopi culture and way of life at the Hopi Reservation in Arizona. The Hopi are the oldest living culture in the United States. The continued existence of the Reservation is threatened by depletion of the groundwater resource underlying the reservation. In the future, without a new source of water, the Hopi will run out of water to support the villages and continue their traditional Hopi agricultural practices. Many Hopi will have to move off the Reservation and give up their traditional culture and way of life. The Reservation will no longer serve as a permanent home for the Hopi Tribe. An expensive pipeline would be required to convey a new source of water to the Reservation, for which the Federal government might pay. The question is: would the expenditure by the federal government to convey water that would ensure the continued existence of the traditional Hopi culture at the Hopi Reservation be justified by the existence value of that culture to the American people? This paper describes the results of a study undertaken to measure that existence value. We show that a simple stated preference design, using only a single monetary amount, is sufficient to provide a bound.
No Man is an Island: Social Coordination and the Environment
Authors: Nyborg Karine 
Published: March 2020

AbstractHumans are fundamentally social. Social activities require coordination, possibly leading to multiple equilibria in the form of self-reinforcing patterns of herd behavior. When alternative equilibria differ substantially with respect to environmental damage, they represent virtuous and vicious cycles from an environmental perspective. Such cycles can be sustained by network effects, social pressure to conform, or other mechanisms directly or indirectly yielding coordination benefits. Breaking the vicious cycles can be an important task for environmental policies. I present a stylized model of social coordination with environmental externalities, using it to discuss how environmental policies may help agents coordinate in more environment-friendly ways.
Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits
Authors:   the Eurosibs Team, Hendry Alexandra , Jones Emily J. H. , Bedford Rachael , Andersson Konke Linn , Begum Ali Jannath , Bӧlte Sven , Brocki Karin C. , Demurie Ellen , Johnson Mark , Pijl Mirjam K. J. , Roeyers Herbert , Charman Tony 
Published: March 2020

AbstractAutism is frequently associated with difficulties with top-down attentional control, which impact on individuals’ mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N = 294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7–9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years.
Co-precipitation synthesized nanostructured Ce0.9Ln0.05Ag0.05O2−δ materials for solar thermochemical conversion of CO2 into fuels
Authors: Takalkar Gorakshnath , Bhosale Rahul R. , AlMomani Fares , Rashid Suliman 
Published: March 2020

AbstractSynthesis, characterization, and application of Ce0.9Ln0.05Ag0.05O2−δ materials (where, Ln = La, Pr, Nd, Sm, Gd, Tb, Dy, Er) for the thermochemical conversion of CO2 reported in this paper. The Ce0.9Ln0.05Ag0.05O2−δ materials were synthesized by using an ammonium hydroxide-driven co-precipitation method. The derived Ce0.9Ln0.05Ag0.05O2−δ materials were characterized via powder X-ray diffraction, scanning electron microscope, and electron diffraction spectroscopy. The characterization results indicate the formation of spherically shaped Ce0.9Ln0.05Ag0.05O2−δ nanostructured particles. As-prepared Ce0.9Ln0.05Ag0.05O2−δ materials were further tested toward multiple CO2 splitting cycles by utilizing a thermogravimetric analyzer. The results obtained indicate that all the Ce0.9Ln0.05Ag0.05O2−δ materials produced higher quantities of O2 and CO than the previously studied pure CeO2 and lanthanide-doped ceria materials. Overall, the Ce0.911La0.053Ag0.047O1.925 showed the maximum redox reactivity in terms of O2 release (72.2 μmol/g cycle) and CO production (136.6 μmol/g cycle).
Sufficiency and the Threshold Question
Authors: Huseby Robert 
Published: March 2020

AbstractIn this paper I address the objection to sufficientarianism posed by Paula Casal and Richard Arneson, that it is hard to conceive of a sufficiency threshold such that distribution is highly important just below it, and not required at all just above it. In order to address this objection, I elaborate on the idea that sufficientarianism structurally can be seen to require two separate thresholds, which may or may not overlap. I then argue that a version of such a view is plausible. Lastly, I distinguish this view from related proposals in the literature.
An evaluation of the Acromegaly Treatment Satisfaction Questionnaire (Acro-TSQ) in adult patients with acromegaly, including correlations with other patient-reported outcome measures: data from two large multicenter international studies
Authors: Fleseriu Maria , Fogelfeld Leon , Gordon Murray B. , Sisco Jill , Crosby Ross D. , Ludlam William H. , Haviv Asi , Mathias Susan D. 
Published: March 2020

AbstractPurposeThe Acromegaly Treatment Satisfaction Questionnaire (Acro-TSQ) is a new patient-reported outcome (PRO) measure for patients with acromegaly receiving injectable somatostatin analogs (SSAs) to assess clinical symptoms and adverse drug reaction interference, treatment satisfaction, and convenience. We evaluated its scale structure, reliability, validity, responsiveness, and what constitutes clinically meaningful change.MethodsData from two longitudinal studies (N = 79 and 82) of patients receiving a stable injectable SSA dose for ≥ 6 months who completed the Acro-TSQ and other collateral measures (e.g., AcroQoL, AIS, WPAI:SHP, EQ-5D-5L) were analyzed.ResultsThe first study demonstrated internal consistency of the Acro-TSQ. However, several items had high ceiling effects, responsiveness could not be established, and the minimally important difference (MID) was not estimable. In the second study, factor analysis revealed six scales: Symptom Interference, Treatment Convenience, Injection Site Interference, GI Interference, Treatment Satisfaction, and Emotional Reaction. Internal consistency and test–retest reliability were confirmed; most scales demonstrated significant differences in mean scores by disease severity. Correlations between Acro-TSQ scales and other collateral measures exceeded 0.30 in absolute value, confirming convergent validity. Responsiveness in Acro-TSQ scale scores reflected improved disease control. The MID was estimated for Symptom Interference (10–12 points), Treatment Convenience (9–11) and GI Interference (8–10).ConclusionsThe Acro-TSQ is a brief, yet comprehensive tool to monitor important outcomes associated with injectable acromegaly SSA treatments. Its content reflects both disease and treatment burden as well as patient satisfaction, and its relevant for use in clinical studies.
Voluntary Vs Nominated Peer Educators: a Randomized Trial within the NoTrap! Anti-Bullying Program
Authors: Zambuto Valentina , Palladino Benedetta Emanuela , Nocentini Annalaura , Menesini Ersilia 
Published: March 2020

AbstractThere is a debate in scientific literature about the effectiveness of a peer-led approach to anti-bullying interventions. In order to understand which circumstances and for whom these approaches work best, the present study was carried out within the NoTrap! anti-bullying program. Using a cluster design, classes were randomly assigned into two different peer educator recruitment strategies: volunteering (N = 500; 48% females; mean age = 13.5 years, ds = 1.3) vs peer nominated (N = 466; 38% females; mean age = 13.9 years, ds = 1.3). Results showed that voluntary peer educators suffered a higher level of victimization, while the nominated ones tended to be more popular and likable. Furthermore, a set of linear mixed-effect models showed that the program was effective in reducing bullying and victimization, and in increasing defending behaviour only in the voluntary recruitment condition. On the contrary, in classrooms under the peer nominated recruitment condition, bullying and victimization remained stable, and defending behaviour increased only for peer educators, but not for their classmates. This implies that the step of peer selection and recruitment must be kept into consideration in developing and validating an intervention, because of its possible impact on the effectiveness of the whole intervention.
An application of hypergeometric functions to heat kernels on rectangular and hexagonal tori and a “Weltkonstante”-or-how Ramanujan split temperatures
Authors: Faulhuber Markus 
Published: March 2020

AbstractIn this work we investigate the heat kernel of the Laplace–Beltrami operator on a rectangular torus and the according temperature distribution. We compute the minimum and the maximum of the temperature on rectangular tori of fixed area by means of Gauss’ hypergeometric function $$_2F_1$$

2

F
1

and the elliptic modulus. In order to be able to do this, we employ a beautiful result of Ramanujan, connecting hypergeometric functions, the elliptic modulus and theta functions. Also, we investigate the temperature distribution of the heat kernel on hexagonal tori and use Ramanujan’s corresponding theory of signature 3 to derive analogous results to the rectangular case. Lastly, we show connections to the problem of finding the exact value of Landau’s “Weltkonstante”, a universal constant arising in the theory of extremal holomorphic mappings; and for a related, restricted extremal problem we show that the conjectured solution is the second lemniscate constant.
Kindliches Wohlbefinden in unterschiedlichen Familienformen: ein Fokus auf komplexe Stieffamilien
Authors: Entleitner-Phleps Christine , Walper Sabine 
Published: March 2020

ZusammenfassungIm Kontext wachsender Scheidungsraten wurden dem kindlichen Wohlbefinden in Stief- und alleinerziehenden Familien in den letzten Jahrzehnten viel Aufmerksamkeit geschenkt. Die Heterogenität von Stieffamilien wurde dabei allerdings weitgehend vernachlässigt. Basierend auf Daten des repräsentativen Surveys „Aufwachsen in Deutschland: Alltagswelten“ (2009,N = 2144) vergleicht die vorliegende Studie das selbst berichtete Wohlbefinden (SDQ) von Kindern (9–12 Jahre) in Kernfamilien, Stiefvaterfamilien, komplexen Stieffamilien mit mindestens einem gemeinsamen Kind und Familien mit einer alleinerziehenden Mutter. Die Ergebnisse zeigen, dass Kinder, die mit einer alleinerziehenden Mutter oder in einer komplexen Stieffamilie leben, Nachteile hinsichtlich ihres Wohlbefindens aufweisen. Die Kinder geben ein schlechteres Familienklima und mehr Streit in der Familie an als Kinder in Kernfamilien. Bei Kindern aus (einfachen) Stiefvaterfamilien konnten keine Nachteile nachgewiesen werden. Die Interpretation der Ergebnisse verweist auf unterschiedliche Risiken und Herausforderungen, mit denen einerseits Alleinerziehende, andererseits aber auch komplexere Stieffamilienformen konfrontiert sind.
Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer
Authors: Yang Jie 
Published: March 2020

AbstractGastric cancer (GC) is one of the most common malignant tumors in the world, and it is also the third largest cause of cancer-related death in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of gastric cancer. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The gene expression profiles of GSE2685 were downloaded from GEO database. Morpheus was used to calculate the differentially expressed genes (DEGs) between primary advanced gastric cancer tissues and noncancerous gastric tissues. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed, and protein–protein interaction (PPI) network of DEGs was constructed. Kaplan–Meier Plotter was used to determine the overall survival (OS) outcomes of UC5AC, MUC1, KRT7, GAPDH, CD44, and GEPIA was used to determine the Pearson correlation analysis. In total, 710 DEGs were identified in GC, including 396 upregulated genes and 314 downregulated genes. GO enrichment revealed that they were mainly enriched in binding, catalytic activity, cellular process and cell. KEGG pathway revealed that they were mainly enriched in metabolic pathways, pathways in cancer and PI3K-Akt signaling pathway. MUC5AC, MUC1, KRT7, GAPDH, CD44 were identified from the PPI network. MUC5AC, MUC1, KRT7, GAPDH, CD44 were demonstrated to have prognostic value for patients with GC. MUC5AC, MUC1 exhibited low expression levels in GC tissues, KRT7, GAPDH, CD44 presented high expression levels in GC tissues. In particular, KRT7 is hardly expressed in normal gastric tissues. MUC5AC and MUC1 were negatively correlated with GAPDH, CD44, respectively; and GAPDH was positively correlated with CD44 and KRT7, respectively. Moreover. MUC5AC, MUC1, KRT7, GAPDH, and CD44 are not only related to GC but also to apoptosis pathway. Results from the present study suggested that MUC5AC, MUC1, KRT7, GAPDH, CD44 may represent novel prognostic biomarkers for GC.
Social Activity in Gothenburg’s Intermediate City: Mapping Third Places through Social Media Data
Authors: Adelfio Marco , Serrano-Estrada Leticia , Martí-Ciriquián Pablo , Kain Jaan-Henrik , Stenberg Jenny 
Published: March 2020

AbstractThis research focuses on the intermediate city, composed of urban areas located right outside the city center typically maintaining an in-between urban/suburban character. It aims to explore the degree to which this segment of the city exhibits urban activity and social life through the identification of activity areas in the so-called Third Places. Four intermediate city neighborhoods in Gothenburg, Sweden are adopted as case areas and are analyzed using a twofold approach. First, socio-economic statistics provide a quantitative understanding of the case areas and, second, geolocated Social Media Data (SMD) from Foursquare, Google Places and Twitter makes it possible to identify the intermediate city’s urban activity areas and socially preferred urban spaces. The findings suggest that a) the four analyzed intermediate city areas of Gothenburg all have a degree of social activity, especially where economic activities are clustered together; b) Third Places in more affluent areas tend to be linked to commodified consumption of urban space while neighborhoods with lower income levels and higher ethnic diversity seem to emphasize open public space as Third Places; and c) nowadays the typology of Third Places has evolved from the types identified in previous decades to include additional types of places, such as those you pass on the way to something else (e.g. gas and bus stations). The study has verified the value of SMD for studies of urban social life but also identified a number of topics for further research. Additional sources of SMD should be identified to secure a just representation of Third Places across diverse social groups. Furthermore, new methods for effective cross validation of SMD with other types of data are crucial, including e.g. statistics, on-site observations and surveys/interviews, not least to identify Third Places that are not frequently present (or are misrepresented) in SMD.