bluuebunny/crossref_metadata_2025_split huggingface dataset:
LHC constraints on $$W^\prime ,~Z^\prime $$ that couple mainly to third generation fermions
Authors: Hayreter Alper , He Xiao-Gang , Valencia German 
Published: November 2020

AbstractWe use the results of CMS and ATLAS searches for resonances that decay to $$\tau \nu $$

τ
ν

or tb and $$\tau ^+\tau ^-$$

τ
+

τ
-

or $$t{\bar{t}}$$

t

t

¯

final states to constrain the parameters of non-universal $$W^\prime $$

W
′

and $$Z^\prime $$

Z
′

gauge bosons that couple preferentially to the third generation. For the former we consider production from $$c\bar{b}$$

c

b

¯

annihilation and find very weak constraints on the strength of the interaction and only for the mass range between 800 and 1100 GeV from the $$pp \rightarrow \tau _h p_T^{\mathrm{miss}}$$

p
p
→

τ
h

p
T
miss

channel. The constraints on the latter are much stronger and arise from both $$t{\bar{t}}$$

t

t

¯

and $$\tau ^+\tau ^-$$

τ
+

τ
-

production. Treated separately, we find that the weak constraints on the $$W^\prime $$

W
′

still permit an explanation of the $$R(D^{(\star )})$$

R
(

D

(
⋆
)

)

anomalies with a light sterile neutrino whereas the stronger constraints on the $$Z^\prime $$

Z
′

exclude significant light sterile neutrino contributions to the $$K \rightarrow \pi \nu \bar{\nu }$$

K
→
π
ν

ν

¯

rates. Within specific models the masses of $$W^\prime $$

W
′

and $$Z^\prime $$

Z
′

are of course related and we briefly discuss the consequences.
Black and White Differences in Colorectal Cancer Screening and Screening Outcomes: A Narrative Review
Authors: Rutter Carolyn M. , Knudsen Amy B. , Lin Jennifer S. , Bouskill Kathryn E. 
Published: November 2020

Abstract
Racial disparities in colorectal cancer incidence are widely documented. There are two potential mechanisms for these disparities: differences in access to screening, including screening follow-up, and differences in underlying risk of colorectal cancer. We reviewed the literature for evidence of these two mechanisms. We show that higher colorectal cancer incidence in blacks relative to whites emerged only after the dissemination of screening and describe evidence of racial disparities in screening rates. In contrast to the strong evidence for differences in colorectal cancer screening utilization, there is limited evidence for racial differences in adenoma prevalence. In general, black and white patients who are screened have similar adenoma prevalence, though there is some evidence that advanced adenomas and adenomas in the proximal colon are somewhat more likely in black than white patients. We conclude that higher rates of colorectal cancer incidence among black patients are primarily driven by lower rates of colorectal cancer screening. Our findings highlight the need to increase black patients' access to quality screening to reduce colorectal cancer incidence and mortality.
A New Generation of “Magic Bullets” for Molecular Targeting of Cancer
Authors: Capala Jacek , Kunos Charles A. 
Published: November 2020

Abstract
A two-step molecular targeting approach involving a self-assembling and disassembling (SADA) bispecific antibody platform and DOTA-radioconjugates allows tumor-specific delivery of diagnostic and therapeutic payloads. Low immunogenicity and the modular nature of SADA allow its optimization to safely and repeatedly deliver a variety of payloads to tumors expressing diverse tumor-specific antigens.
See related article by Santich et al., p. 532
The Political Imperative of World Cinema
Authors: Mazaj Meta , Deshpande Shekhar 
Published: November 2020

Abstract
This paper argues for the political urgency of the project of World Cinema, and an understanding of World Cinema as a dynamic totality. Totality here is not a generic, macroscopic lens, but a system that accounts for the co-existence of all cinemas as well as the uneven power relationships that determine the relative visibility or invisibility of cinemas in the global system. This structural inequity, a condition that underlies the differentiated cinematic flows, is also a methodological ruse in that it can only point to unequal relationships in discourses that define the current conceptions of World Cinema. An awareness of totality, we argue, makes it possible to return to films themselves as nodal points from which to begin the mapping of World Cinema through its complex networks of financing, distribution, and its circuits of legitimation (film festivals, academic discourses) which shape world cinema as a body of knowledge.
Recommendations for Future Research Priorities for Climate Modeling and Climate Services
Authors: Hewitt C. D. , Guglielmo F. , Joussaume S. , Bessembinder J. , Christel I. , Doblas-Reyes F. J. , Djurdjevic V. , Garrett N. , Kjellström E. , Krzic A. , Costa M. Máñez , St. Clair A. L. 
Published: November 2020

AbstractClimate observations, research, and models are used extensively to help understand key processes underlying changes to the climate on a range of time scales from months to decades, and to investigate and describe possible longer-term future climates. The knowledge generated serves as a scientific basis for climate services that are provided with the aim of tailoring information for decision-makers and policy-makers. Climate models and climate services are crucial elements for supporting policy and other societal actions to mitigate and adapt to climate change, and for making society better prepared and more resilient to climate-related risks. We present recommendations for future research topics for climate modeling and for climate services. These recommendations were produced by a group of experts in climate modeling and climate services, selected based on their individual leadership roles or participation in international activities. The recommendations were reached through extensive analysis, consideration and discussion of current and desired research capabilities, and wider engagement and refinement of the recommendations was achieved through a targeted workshop of initial recommendations and an open meeting at the European Geosciences Union General Assembly. The findings emphasize how research and innovation activities in the fields of climate modeling and climate services can contribute to improving climate knowledge and information with saliency for users in order to enhance capacity to transition to a sustainable and resilient society. The findings are relevant worldwide but are deliberately intended to influence the European Commission’s next major multi-annual framework program of research and innovation over the period 2021–27.
Positive Margins in Cutaneous Melanoma of the Head and Neck: Implications for Timing of Reconstruction
Authors: Namin Arya W. , Welby Lauren , Baker Austin T. , Dooley Laura M. 
Published: November 2020

ObjectiveThe aim of this study is to identify clinicopathologic features associated with positive margins after surgical treatment of cutaneous melanoma of the head and neck (CMHN).Study DesignRetrospective cohort study.SettingNational Cancer Database.MethodsA retrospective analysis of the National Cancer Database was performed of patients diagnosed with CMHN between 2004 and 2016. Univariate and multivariate analyses examining the association of clinicopathologic features with positive margins were performed via logistic regression analysis.ResultsA total of 101,560 patients met inclusion criteria. The incidence of positive margins was 5.0% (5128/101,560). Patients were significantly more likely to have positive margins with the following: increasing age (P <. 001; odds ratio [OR], 1.028; 95% CI, 1.026‐1.031), the lip subsite (P <. 001; OR, 1.664; 95% CI, 1.286‐2.154), the eyelid subsite (P <. 001; OR, 2.380; 95% CI, 1.996‐2.838), the face subsite (P <. 001; OR, 1.215; 95% CI, 1.133‐1.302), the lentigo maligna/lentigo maligna melanoma subtype (P =. 019; OR, 1.099; 95% CI, 1.016‐1.188), the desmoplastic subtype (P <. 001; OR, 1.455; 95% CI, 1.261‐1.680), the spindle cell subtype (P =. 006; OR, 1.276; 95% CI, 1.073‐1.516), and advanced pT classification. Patients with male sex (P <. 001; OR, 0.733; 95% CI, 0.687‐0.782) and without ulceration (P <. 001; OR, 0.803; 95% CI, 0.736‐0.876) were significantly less likely to have positive margins.ConclusionThe following have been identified as clinicopathologic features associated with positive margins after surgical treatment of CMHN: increasing age, female sex, the lip subsite, the eyelid subsite, the face subsite, ulceration, the lentigo maligna/lentigo maligna melanoma subtype, the desmoplastic subtype, the spindle cell subtype, and increasing pT classification.
Dissociation, Stressors, and Coping in Patients of Psychogenic Nonepileptic Seizures
Authors: Sawant Neena S , Umate Maithili S 
Published: November 2020

Background: Psychogenic nonepileptic seizures (PNES) commonly present both to neurologists and psychiatrists and include a wide range of psychopathology. In order to understand the demographics, dissociative experiences, stressful life events, abuse, and coping in these patients, this study was undertaken. Methods: This was a cross-sectional, observational study. A total of 71 patients of PNES, referred from neurology, were assessed on Dissociative Experience Scale (DES), Scale For Trauma and Abuse, Presumptive Stressful Life Events Scale (PSLES), and Ways of Coping Questionnaire to ascertain the dissociative experiences; the prevalence of trauma, abuse, and stressful life events, and the coping mechanisms. Results: Females predominated, with the duration of PNES up to 2 years. The mean ± SD total DES score was 38.14 ± 14.1, indicating high dissociation. On the PSLES, for the stressful life events in the last one year, the mean score was 98.28 ± 87.1. Marital and family conflicts and death were reported more. History of childhood or adult physical and sexual abuse was less reported. History of head trauma was present in 13 patients. Emotion-focused coping was used more than problem-solving strategies. Conclusions: Very few Indian studies have looked into these nuances. This study has helped in improving the understanding of the various risk factors of PNES and the coping strategies, and in sensitizing psychiatrists and neurologists to enquire into trauma and abuse of these patients.
Venous or arterial samples for activated clotting time measurements: a systematic review
Authors: Iddawela Sashini , Swamy Priti , Member Sajid , Harky Amer 
Published: November 2020

Objective: The systematic review aims to investigate the effect of sampling source on activated clotting time (ACT) measurement within cardiovascular surgery and cardiac catheterisation. It also examines the evidence surrounding novel clot assessment techniques and associated sampling variation. Methods: A comprehensive electronic search was conducted using PubMed, MEDLINE, Scopus, Cochrane database, and Google Scholar until 20th June 2020. All studies reporting sampling source variability of ACT in cardiac surgery, vascular surgery and cardiac catheterisation were included. Results: Fourteen studies were included in the systematic review. Inconsistent reports of variability were seen in cardiac surgery and cardiac catheterisation. There were no studies directly examining ACT variability in vascular surgery. Novel clot assessment techniques have been validated in cardiac surgery, but measurements vary depending on sampling source. Conclusion: Sampling source should be kept consistent to facilitate effective haemostatic strategies. More research is needed regarding variability in vascular surgery and novel clot assessment techniques.
Higher baseline lipid levels amplify the benefit of secondary prevention therapy with statins in Chinese patients with acute coronary syndrome
Authors: Zhu Ling , Liu Ying , Zhang Wei , Zhang Zhu , Zhou Liqin , Zhang Hong , Zhang Yong , Liu Fuqiang , Liu Peng , Liu Zhongwei , Wang Junkui 
Published: November 2020

Objective Statins are recommended as the first-line treatments for reducing the risk of major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). The present study aimed to establish the baseline lipid levels associated with the greatest benefit from statin therapy in this population. Methods The study used a retrospective cohort methodology. In total, 636 patients with ACS were enrolled at Shaanxi Provincial People’s Hospital from 2011 to 2013. Participants were divided into four groups (group 1, hyperlipidemia with inconsistent statin use; group 2, no hyperlipidemia with inconsistent statin use; group 3, no hyperlipidemia with consistent statin use; and group 4, hyperlipidemia with consistent statin use). Results Patients in groups 3 (hazard ratio [HR] = 0.49, 95% confidence interval [CI] = 0.29–0.82) and 4 (HR = 0.21, 95% CI = 0.10–0.45) had lower risks of MACE than those in group 1. In subgroup analysis, patients in group 4 had a lower risk of MACE than those in group 3 (adjusted HR = 0.43, 95% CI = 0.21–0.89). Conclusion Sustained statin therapy is associated with a lower risk of adverse outcomes in patients with ACS, especially in those with higher baseline lipid levels.
Maternal Substance Abuse and the Later Risk of Fractures in Offspring: L’abus maternel de substances et le risque ultérieur de fractures chez les enfants
Authors: Auger Nathalie , Low Nancy , Ayoub Aimina , Lee Ga Eun , Luu Thuy Mai 
Published: November 2020

Objective: To assess the association of maternal illicit drug abuse before or during pregnancy with future fractures in offspring. Methods: We performed a longitudinal cohort study of 792,022 infants born in hospitals of Quebec, Canada, between 2006 and 2016, with 5,457,634 person-years of follow-up. The main exposure was maternal substance abuse before or during pregnancy, including cocaine, opioid, cannabis, and other illicit drugs. The main outcome measure was hospitalization for traumatic fracture in offspring up to 12 years of age. We used adjusted Cox regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association of maternal drug abuse with the subsequent risk of fracture in children. Results: The incidence of child fractures was higher for maternal illicit drug abuse than no drug abuse (21.2 vs. 15.4 per 10,000 person-years). Maternal drug abuse before or during pregnancy was associated with 2.35 times the risk of assault-related fractures (95% CI, 1.29 to 4.27) and 2.21 times the risk of transport accident-related fractures (95% CI, 1.34 to 3.66), compared with no drug abuse. Associations were strongest before 6 months of age for assault-related fractures (HR = 2.14; 95% CI, 0.97 to 4.72) and after 6 years for transport-related fractures (HR = 2.86; 95% CI, 1.35 to 6.05). Compared with no drug abuse, associations with assault and transport-related fractures were elevated for all drugs including cocaine, opioids, and cannabis. Conclusions: Maternal illicit drug abuse is associated with future child fractures due to assault and transport accidents.
Feline morbillivirus in northwestern Italy: first detection of genotype 1-B
Authors: Muratore Elvira , Cerutti Francesco , Colombino Elena , Biasibetti Elena , Caruso Claudio , Brovida Claudio , Cavana Paola , Poncino Laura , Caputo Maria Pia , Peletto Simone , Masoero Loretta , Capucchio Maria Teresa 
Published: November 2020

Objectives A novel morbillivirus was recently described in stray and domestic cats in Asia, the USA and Europe. Most cats infected with feline morbillivirus (FeMV) showed lower urinary tract or kidney disease. Although the association of FeMV infection and kidney diseases has been suggested, the virus pathogenicity remains unclear. The present study aimed to investigate the distribution of FeMV infection, as well as the relationship between FeMV infection and kidney diseases in cats from northwestern Italy. Methods A total of 153 urine samples (150 individuals and three pools) and 50 kidney samples were collected and included in the study; total RNA was extracted and a reverse transcription quantitative PCR (RT-qPCR) was performed in order to identify FeMV. Kidneys were also submitted to anatomopathological examination. Phylogenetic analysis and isolation attempts were carried out on positive samples. In FeMV-positive cats, urinalysis and blood analysis were performed. Results FeMV RNA was detected in 7.3% of urine samples and in 8% of kidney samples, both in healthy cats and in cats with clinical signs/post-mortem lesions compatible with kidney disease. At histopathological examination, tubulointerstitial nephritis (TIN) was shown in 3/4 positive kidney samples, but a clear relationship between FeMV and TIN was not observed. Isolation attempts were unsuccessful, although the urine sample of one castrated male cat hosted in a cattery showed a positive signal in RT-qPCR until the fourth cell passage. Phylogenetic analysis revealed that this FeMV strain belonged to genotype 1-B. In the same cattery, a second genotype 1-B variant was detected from a urine pool. Urinalysis showed proteinuria in three cats, while at blood analysis three cats presented altered creatinine levels. Conclusions and relevance Data reported suggest the presence of a FeMV sub-cluster distinct from the strain previously isolated in Italy, whose role in renal disorders remains uncertain.
Treatment of Reducible Atlantoaxial Dislocation and Basilar Invagination Using the Head Frame Reduction Technique and Atlantoaxial Arthrodesis
Authors: Li Teng , Du Yue-Qi , Yin Yi-Heng , Xing Shao-Ling , Qiao Guang-Yu 
Published: November 2020

Study design: Retrospective case series. Object: To evaluate the outcomes of a head frame reduction and atlantoaxial arthrodesis technique for the treatment of reducible basilar invagination (BI) and atlantoaxial dislocation (AAD). Methods: Seventy-two reducible BI and AAD cases who were treated with the head frame reduction and atlantoaxial arthrodesis technique from June 2015 to December 2018 were retrospectively analyzed. Radiological measurements including the atlantodental interval (ADI), the height of odontoid process above Chamberlain line, Wackenheim line, clivus-canal angle (CCA) and JOA score were evaluated. Results: There was no death in this series. The follow-up period ranged from 6 to 32 months (mean: 21.2 months). Radiological, complete or 90% reduction was attained and complete decompression was demonstrated in all patients. The CCA increased from 123.22 ± 8.36 preoperatively to 143.05 ± 8.79 postoperatively (P < 0.01). There was no patient found postoperative dysphagia. Neurological improvement was observed in all patients, with the JOA scores increasing from 12.53 ± 1.93 preoperatively to 16.13 ± 1.23 postoperatively (P < 0.01). Solid bony fusion was demonstrated in 69 patients at follow-up (95.8%). Conclusion: Head frame reduction technique is a simple and effective treatment which could relief neurologic compression and adjust the CCA in patients with reducible AAD and BI with lower potential risks. Atlantoaxial fixation with short segmental fixation, strong purchase and low shearing force could maintain superior stabilization. The safety and long-term efficacy of such fixation and reduction technique were favorable, which illustrated that it could be a promising treatment algorithm for such kind of disease.
Competency of Academic Nurse Educators
Authors: Satoh Miho , Fujimura Akiko , Sato Naoko 
Published: November 2020

Background In the face of a rapidly changing social environment and increasing demand for health care services, there is a global concern that academic nurse educators should have expert-level competencies and should improve the level of nursing education. Objective This study aimed to investigate the elements that constitute competency in academic nurse educators. Methods A cross-sectional self-completed online survey was conducted involving academic nurse educators working at universities in Japan. We invited 277 nursing universities to participate in the survey and to provide academic nurse educators with information about the research by contacting the dean of each university’s nursing department. In total, 372 educators completed the survey (response rate 4.03%), and after excluding those with incomplete data, 367 were analyzed (valid response rate 3.97%). The data were analyzed by exploratory-factor analysis, with the least-squares method and promax rotation performed. Results An exploratory analysis yielded five competency factors: “facilitating active learning,” “engaging in academic research activities,” “participating in university management,” “undertaking self-directed learning based on professional ethics,” and “practicing education autonomously.” Conclusions The competencies identified in the present study are essential for academic nurse educators, and the five factors are in accord with the findings of previous studies. Support systems for academic nursing educators should be established to improve their competencies comprehensively. However, further research is needed to develop the competencies of academic nurse educators into more comprehensive and sophisticated competencies.
Multiple Evanescent White Dot Syndrome Presenting in a Patient With Punctate Inner Choroidopathy
Authors: Walters Alexander R. , Choi Rene Y. , Flaxel Christina J. 
Published: November 2020

Purpose: This work reports a case of long-standing punctate inner choroidopathy (PIC) presenting with acute-onset multiple evanescent white dot syndrome. Methods: A 44 year-old man presented with new onset of flashes and a peripheral spot of blurry vision in the right eye. His ocular history included PIC in both eyes. Results: Corrected visual acuities and intraocular pressures were normal. Posterior segment examination of the right eye demonstrated old PIC lesions and new, deep-yellow lesions in the posterior pole and midperiphery. Four months later, these lesions had resolved. Conclusions: Coexistence of PIC and multiple evanescent white dot syndrome has been rarely reported, and more research is warranted to investigate a possible shared etiology.
Platinum-group minerals from the Malaya Kamenushka River placer, Middle Urals, Russia
Authors: Palamarchuk Roman S. , Stepanov Sergey Yu. , Kozlov Aleksandr V. , Khanin Dmitry A. , Varlamov Dmitry A. , Zolotarev Andrey A. , Kiseleva Daria V. , Shilovskikh Vladimir V. 
Published: November 2020

AbstractThis work presents a detailed study of platinum-group mineral (PGM) assemblages from the Malaya Kamenushka River placer, whose formation is associated with the weathering of the Kamenushensky Uralian–Alaskan type massif, Middle Urals, Russian Federation. The deposit is characterised by the dominance of isoferroplatinum, together with significant numbers of inclusions of Os–Ir–Ru alloys and platinum-group element (PGE) sulfides. A study of the Os–Ir–Ru alloys permitted recognition of two types of iridium with different morphology and composition. The similarity of the PGM assemblages from the Malaya Kamenushka River placer and the lode mineralisation of the Kamenushensky massif is demonstrated. A comparison of PGM assemblages from the Malaya Kamenushka River placer with other placers and massifs of the Ural platinum belt demonstrates significant differences in the number of Os–Ir–Ru inclusions. Such differences for minerals of refractory elements cannot be explained by the vertical zoning of the lode mineralisation. Most probably this is associated with the enrichment of the primary substrate with Os, Ir and Ru and/or the degree of melting, depending on the chosen model of formation of the Uralian–Alaskan type massifs.