bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thoracic Wall Reconstruction
Authors: Groth Anne Karoline , Pazio André Luiz Bilieri , Kusano Larissa Dalla Costa , Lupion Fabiola , Itikawa William Massami , Legnani Bruno Cesar , Ono Maria Cecilia Closs , da Silva Alfredo Benjamin Duarte 
Published: February 2020

Introduction
The reconstruction of defects in thoracic wall remains a challenge for plastic surgeons. Advances in surgical treatment of illnesses of thoracic wall have been fostering the treatment of lesions within more advanced levels. Consequently, larger and more complex defects are generated, demanding soft tissue covering and framework repair.

Objective
The aim of this study was to report the experience in chest wall reconstruction and demographics of a tertiary cancer center.

Methods
All patients submitted to thoracic wall reconstruction by the plastic surgery department from January 2012 to May 2018 in a tertiary cancer center were evaluated.

Results
Thirty-two patients have undergone thoracic wall reconstruction. The majority of patients in our series were submitted to surgical treatment of locally advanced breast cancer (84.3%). The most common defect location was the right anterolateral region (65.6%). The latissimus dorsi musculocutaneous flap was the most used in thoracic wall reconstructions. Three cases of thoracectomy with rib resection were reconstructed with methylmethacrylate and polypropylene surgical mesh associated with musculocutaneous flap. Four patients presented major complications, and 12 patients (37.5%) presented minor complications. There were no deaths related to procedures or instability of thoracic wall. Twenty-two patients presented progression of the disease, and 16 died due to the primary pathology.

Conclusions
Extended resection of the chest wall is associated in most cases with advanced disease, especially advanced breast cancer. Despite poor prognosis associated to locally advanced disease, it is imperative to perform chest wall reconstruction and allow the patient to continue adjuvant therapy (radiotherapy or chemotherapy) and improve quality of life.
Effect of Cross-Sex Hormone Therapy on Venous Thromboembolism Risk in Male-to-Female Gender-Affirming Surgery
Authors: Haveles Christos S. , Wang Maxwell M. , Arjun Arpana , Zaila Kassandra E. , Lee Justine C. 
Published: February 2020

Abstract
Individuals with gender dysphoria often seek medical interventions, such as hormone treatment and surgery, to live as their identified gender. Cross-sex hormone therapy typically consists of various estrogen formulations which confer varying risks of venous thromboembolism (VTE). Currently, there is no standard practice by surgeons regarding the preoperative gender-affirming surgery (GAS) hormone regimen of male-to-female (MTF) patients to minimize thromboembolic postoperative complications. The aim of this review is to examine the current literature on VTE occurring in MTF transgender patients on cross-sex hormone therapy (CSHT) when undergoing various gender-affirming surgeries—facial feminization surgery (FFS), top surgery (TS), and bottom surgery (BS)—to understand how evidence-based recommendations regarding perioperative hormone regimens can be established to improve clinical outcomes. Within the past 25 years, 7 published studies have examined the incidence of VTE in MTF patients undergoing GAS procedures. Two of these articles examined MTF patients undergoing FFS, 1 article reported a patient who had undergone BS and FFS during the same hospitalization, and the remaining 4 articles investigated VTE risk in BS. Our review supports that plastic surgeons who perform GAS are divided on their preferred CSHT protocols, with some requiring patients to suspend their CSHT weeks before surgery and others allowing patients to continue CSHT through the day of surgery. Three of the 7 studies detailed a CSHT perioperative regimen which instructed patients to suspend CSHT sometime before surgery; 1 study tapered CSHT to lower levels before surgery; the remaining 3 studies did not specify a CSHT perioperative regimen. This review highlights the paucity of data failing to support that continuing CSHT through GAS elevates VTE risk. We conclude that in the absence of definitive VTE risk factors (e.g., smoking, clotting disorders, or malignancy), surgeons may engage MTF patients in joint decision-making process to determine the most optimal perioperative CSHT management plan on a case-by-case basis. Future studies are warranted to evaluate VTE risk based on patient age, type of surgery, operating time, prophylactic measures, follow-up time, and CSHT perioperative regimens.
Experimental Approaches to Evaluate Leukocyte–Endothelial Cell Interactions in Sepsis and Inflammation
Authors: Kilpatrick Laurie E. , Kiani Mohammad F. 
Published: February 2020

ABSTRACT
Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host response to infection characterized by excessive neutrophil infiltration into vital organs. In sepsis, patients often die of organ failure and therapies directed against endothelial cell dysfunction and tissue damage are important targets for treatment of this disease. Novel approaches are required to understand the underlying pathophysiology of neutrophil dysregulation and neutrophil–endothelial cell interactions that play a critical role in the early course of organ damage and disruption of endothelial protective barrier. Here, we review methodologies that our laboratories have employed to study neutrophil–endothelial interaction and endothelial barrier function in in vivo and in vitro models of sepsis. We will focus on in vivo rodent models of sepsis and in vitro tools that use human cell culture models under static conditions and the more physiologically relevant biomimetic microfluidic assays. This Methods paper is based on our presentation in the Master Class Symposium at the 41st Annual Conference on Shock 2018.
Circulatory Trauma: A Paradigm for Understanding the Role of Endovascular Therapy in Hemorrhage Control
Authors: Duchesne Juan , Taghavi Sharven , Khan Mansoor , Perreira Bruno , Cotton Bryan , Brenner Megan , Ferrada Paula , Horer Tal , Kauvar David , Kirkpatrick Andrew , Ordoñez Carlos , Priouzram Artai , Roberts Derek 
Published: February 2020

ABSTRACT
The pathophysiology of traumatic hemorrhage is a phenomenon of vascular disruption and the symptom of bleeding represents one or more vascular injuries. In the Circulatory Trauma paradigm traumatic hemorrhage is viewed as injury to the circulatory system and suggests the underlying basis for endovascular hemorrhage control techniques. The question “Where is the patient bleeding?” is replaced by “Which blood vessels are disrupted?” and stopping bleeding becomes a matter of selective vessel access and vascular flow control. Control of traumatic hemorrhage has traditionally been performed via external access to the end organ that is bleeding followed by the application of direct pressure, packing, or clamping and repair of directly affected blood vessels. In the circulatory trauma paradigm, bleeding is seen as disruption to vessels which may be accessed internally, from within the vascular system. A variety of endovascular treatments such as balloon occlusion, embolization, or stent grafting can be used to control hemorrhage throughout the body. This narrative review presents a brief overview of the current role of endovascular therapy in the management of circulatory trauma. The authors draw on their personal experience combined with the last decade of published experiences with the use of endovascular techniques in trauma and present general recommendations for their evolving use. The focus of the review is on the use of endovascular techniques as specific vascular treatments using the circulatory trauma paradigm.
Hemodynamic Impact of Cardiovascular Antihypertensive Medications in Patients With Sepsis-Related Acute Circulatory Failure
Authors: de Roquetaillade Charles , Jamme Matthieu , Charpentier Julien , Chiche Jean-Daniel , Cariou Alain , Mira Jean-Paul , Pène Frédéric , Llitjos Jean-François 
Published: February 2020

ABSTRACT

Background:
Impact of prior cardiovascular antihypertensive medication during the initial phase of septic shock in terms of catecholamine requirements and mortality has been poorly investigated and remains unclear.

Objectives:
To investigate the association between chronic prescription of cardiovascular antihypertensive medication prior to intensive care unit (ICU) admission, catecholamine requirement, and mortality in patients with septic shock.

Methods:
We included all consecutive patients diagnosed with septic shock within the first 24 h of ICU admission, defined as a microbiologically proven or clinically suspected infection, associated with acute circulatory failure requiring vasopressors despite adequate fluid filling. Prior cardiovascular antihypertensive medication was defined as the chronic use of betablockers (BB), calcium channel blockers (CCB), angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor blockers (ARB). ICU mortality was investigated using multivariate competitive risk analysis.

Results:
Among 735 patients admitted for septic shock between 2008 and 2016, 46.9% received prior cardiovascular antihypertensive medication. Prior cardiovascular antihypertensive therapy was not associated with increased norepinephrine requirements during the first 24 h (median = 0.28 μg/kg/min in patients previously treated vs. 0.26 μg/kg/min). Prior cardiovascular antihypertensive medication was not associated with a higher risk of ICU mortality after adjustment (cause-specific hazard = 1.28, 95% confidence interval [0.98–1.66], P = 0.06). Subgroups analyses for BB, CCB, and ACEi/ARB using propensity score analyses retrieved similar results.

Conclusion:
In patients admitted with septic shock, prior cardiovascular antihypertensive medication seems to have limited impact on initial hemodynamic failure and catecholamine requirement.
The Safety and Feasibility of Laparoscopic Technology in Right Posterior Sectionectomy
Authors: Luo Dilai , Xiong Xiaoli , Xiong Hu , Liu Hongliang , Huang Yong , Huang Mingwen 
Published: February 2020

Background:
Laparoscopic hepatectomy has been accepted widely due to its advantages as a minimally invasive surgery, but laparoscopic right posterior sectionectomy (LRPS) has rarely been reported. We aimed to explore the safety and feasibility of LRPS by comparing it with open surgical approaches.

Materials and Methods:
Between January 2014 and July 2019, 51 patients who underwent right posterior sectionectomy were enrolled in this study. The patients’ characteristics, intraoperative details, and postoperative outcomes were compared between 2 groups.

Results:
There were no statistically significant differences in the preoperative data. LRPS showed significantly less blood loss (P=0.001) and shorter hospital stay (P=0.002) than open right posterior sectionectomy, but hospital expenses (P=0.382), operative time (P=0.196), surgical margin (P=0.311), the rate of other complications, and the postoperative white blood cell count, alanine aminotransferase, aspartate aminotransferase, and total bilirubin showed no statistically significant differences between the 2 groups (P>0.05). For hepatocellular carcinoma, the results showed there were no differences in both disease-free survival (P=0.220) and overall survival (P=0.417) between the 2 groups.

Conclusions:
Our research suggests that LRPS is a safe and feasible surgical procedure that is efficient from an oncological point of view. It may be the preferred choice for lesions in the right posterior hepatic lobe.
Characteristics and Impact of Librarian Co-authored Systematic Reviews: A Bibliometric Analysis
Authors: Saleh Ahlam A. , Huebner Frank 
Published: February 2020

ABSTRACTBackgroundHealth sciences libraries have been providing services that support systematic reviews (SRs) for many years. In recent times the problem facing health sciences libraries is the management of the demand versus resources availability. There have been questions posed as to the value of this type of service in health sciences libraries. A valuable outcome of librarian collaboration on SR teams is co-authorship of the reported SRs. This study aimed to examine the characteristics and impact of librarian co-authored SRs.MethodsA bibliometric analysis was conducted. Librarian co-authored SRs were identified in the Web of Science (WOS) Core Collection limited up to the year 2017. Librarian co-authored SRs with the librarian as first author were excluded from this analysis. Additional inclusion and exclusion criteria were applied in the selection process. The included records were analyzed using Perl programs and VOSviewer. To examine the dissemination of librarian co-authored SRs, citing articles to the included SR records were retrieved from the WOS Core Collection and then identified in MEDLINE for an analysis of the indexed publication types.ResultsThe included results yielded 1,711 librarian co-authored SRs published between 1996 and 2017. The top three countries of the first author affiliation were USA, Canada, and Netherlands. Sources of publication were distributed among 730 journal titles. The number of MEDLINE citing articles to the included SRs was 28,868. The mean number of citations to a SR was 26.4. The top publication type descriptor of the citing articles representing the MEDLINE “Study Characteristic” category was “Randomized Controlled Trial”.ConclusionOutcomes of librarian contributions to supporting SRs include increasing scholarship opportunities that highlight librarian contributions to other disciplines. SRs are bodies of evidence, which can influence policy, patient care, and future research. In this study, we demonstrate that librarian co-authored SRs are disseminated into randomized controlled trials and other study types, meta-analyses, as well as guidelines, thus providing insight into knowledge transfer and the potential for clinical implementation.
Estimating the cure rate and case fatality rate of the ongoing epidemic COVID-19
Authors: Diao Ying , Liu Xiaoyun , Wang Tao , Zeng Xiaofei , Dong Chen , Zhang Yuanming , Zhou Changlong , She Xuan , Liu Dingfu , Hu Zhongli 
Published: February 2020

AbstractThe epidemic caused by the novel coronavirus COVID-19 in Wuhan at the end of 2019 has become an urgent public event of worldwide concern. However, due to the changing data of the epidemic, there is no scientific estimate of the cure rate and case fatality rate of the epidemic. This study proposes a method to estimate the cure rate and case fatality rate of COVID-19. The ratio of cumulative discharges on a given day to the sum of cumulative discharges on a given day and cumulative deaths before j days is used to estimate the cure rate. Moreover, the case fatality ratio can also be estimated. After simulation calculations, j is statistically appropriate when it is 8-10, and it is also clinically appropriate. When j is 9, based on the available data, it is inferred that the cure rate of this epidemic is about 93% and the case fatality rate is about 7%. This method of estimating the cure rate can be used to evaluate the effectiveness of treatment in different medical schemes and different regions, and has great value and significance for decision-making in the epidemic.
Overlapping Pathogenic Signalling Pathways and Biomarkers in Preeclampsia and Cardiovascular Disease
Authors: Suvakov Sonja , Bonner Emma , Nikolic Valentina , Jerotic Djurdja , Simic Tatjana P , Garovic Vesna D , Lopez-Campos Guillermo , McClements Lana 
Published: February 2020

AbstractObjectivesPreeclampsia is a cardiovascular pregnancy complication which occurs in 5-10% of pregnancies that can lead to a number of pregnancy complications including maternal and foetal death. Long-term, preeclampsia is associated with up to 8-fold increased risk of cardiovascular disease (CVD) for both mothers and their offspring. The lack of mechanistic data in relation to the causes or consequences of preeclampsia has prevented the development of effective therapeutic or monitoring strategies.Study designThis study investigates common underlying mechanisms of preeclampsia and CVD, specifically hypertension and heart failure with preserved ejection fraction (HFpEF) using “in silico”approach of publicly available datasets. Integrated techniques were designed to mine data repositories and identify relevant biomarkers associated with these three conditions.Main outcomes measuresThe knowledge base tools were employed that enabled the analysis of these biomarkers to discover potential molecular and biological links between these three conditions.ResultsOur bioinformatics “in silico” analyses of the publically available datasets identified 76 common biomarkers between preeclampsia, hypertension and HFpEF. These biomarkers were representative of 29 pathways commonly enriched across the three conditions which were largely related to inflammation, metabolism, angiogenesis, remodelling, haemostasis, apoptosis, endoplasmic reticulum (ER) stress signalling and the renin-angiotensin-aldosterone (RAAS) system.ConclusionsThis bioinformatics approach which uses the wealth of scientific data available in public repositories can be helpful to gain a deeper understanding of the overlapping pathogenic mechanisms of associated diseases, which could be explored as biomarkers or targets to prevent long-term cardiovascular complications such as hypertension and HFpEF following preeclampsia.HighlightsWomen with preeclampsia have increased risk of cardiovascular disease later in life but the mechanism is poorly understood.“In silico” analyses of publically available datasets provided overlapping biomarkers and pathogenic pathways between preeclampsia, hypertension and heart failure with preserved ejection fraction (HFpEF).These data could be utilised in the future studies that may lead to the development of better risk stratification strategies or preventative treatments for women post preeclampsia.
Visual predictions, neural oscillations and Newtonian physics
Authors: Saurels Blake W. , Hohaia Wiremu , Yarrow Kielan , Johnston Alan , Arnold Derek H. 
Published: February 2020

AbstractPrediction is considered a core function of the human visual brain, but relating this suggestion to real life is problematic, as findings regarding the neural correlates of prediction rely on abstracted experiments, not reminiscent of a typical visual diet. We addressed this by having people view videos of basketball, and asking them to predict jump shot outcomes while we recorded eye movements and brain activity. We used the brain’s understanding of physics to manipulate predictive success, by inverting footage. People had enhanced alpha-band activity in occipital brain regions when watching upright videos, and this predicted both an increase in predictive success and enhanced ball tracking. Alpha-band activity in visual brain regions has been linked to inhibition, so we regard our results as evidence that inhibition of task irrelevant information is a core function of predictive processes in the visual brain, enacted as people complete visual tasks typical of daily life.
Oxidative Modifications of Parkin Underlie its Selective Neuroprotection in Adult Human Brain
Authors: Tokarew Jacqueline M. , El-Kodsi Daniel N. , Lengacher Nathalie A. , Fehr Travis K. , Nguyen Angela P. , O’Nuallain Brian , Jin Ming , Khan Jasmine M. , Ng Andy C. H. , Li Juan , Jiang Qiubo , Zhang Mei , Wang Liqun , Sengupta Rajib , Barber Kathryn R. , Tran An , Zandee Stephanie , Dong Xiajun , Scherzer Clemens R. , Prat Alexandre , Tsai Eve , Takanashi Masashi , Hattori Nobutaka , Chan Jennifer A. , West Andrew B. , Holmgren Arne , Puente Lawrence , Shaw Gary S. , Toth Gergely , Woulfe John M. , Taylor Peggy , Tomlinson Julianna J. , Schlossmacher Michael G. 
Published: February 2020

SUMMARYThe mechanisms by which Parkinson disease-linked parkin confers neuroprotection of human dopamine cells remain elusive. We hypothesized that its cysteines mediate multiple anti-oxidant effects in the midbrain. By studying >60 control specimens, we found that in adult human brain - but not in skeletal muscle- parkin is mostly aggregated and insoluble due to oxidative modifications, such as at C253.In vitro, parkin’s oxidation directly reduces hydrogen peroxide (H2O2) to water. In parkin-deficient human brain, H2O2concentrations are elevated. In dopamine toxicity studies, wild-type parkin -but not disease-associated mutants-prevents neural death by lowering H2O2and sequestering radicals within insoluble aggregates. Parkin conjugates dopamine metabolites at the human-specific residue C95 and augments melanin formationin vitro. Using epitope-mapped antibodies, we found that in adultSubstantia nigraneurons parkin localizes to neuromelanin within LAMP-3/CD63-positive lysosomes. We conclude that parkin’s own oxidation, previously considered a loss-of-function event, underlies three neuroprotective effects in adult midbrain: its cysteines participate in H2O2reduction, dopamine radical conjugation and the formation of neuromelanin.
Septins disruption controls tumor growth and enhances efficacy of Herceptin
Authors: Singh Rakesh K , Kim Kyu Kwang , Khazan Negar , Rowswell-Turner Rachael B. , Laggner Christian , Jones Aaron , Srivastava Priyanka , Hovanesian Virginia , Lamere Liz , Conley Thomas , Pandita Ravina , Baker Cameron , Myers Jason R , Pritchett Elizabeth , Ahmad Awada , Ruffolo Luis , Jackson Katherine , Gerber Scott A. , Ashton John , Milano Michael T. , Linehan David , Moore Richard G 
Published: February 2020

AbstractSeptin expressions are altered in cancer cells and exhibit poor prognoses in malignancies. As the first approach to develop a septin filament targeting agent, we optimized the structure of Forchlorfenuron (FCF), a known plant cytokinin to generate UR214-9, which contrary to FCF, causes septin-2/9 filamental structural catastrophe in cancer cells without altering cellular septin protein levels.In-silicodocking using septin-2/septin-2 dimer complex showed that UR214-9 displaced the guanine carbonyl oxygen from the GDP binding domain and showed increased binding energy than FCF(−8.59vs-7.21). UR214-9 reduced cancer cell growth, downregulated HER2/STAT-3 axis and controlled growth of HER2+ pancreatic, breast and ovarian cancer xenografts in NSG mice and enhanced response of Herceptin against HER2+breast cancer xenograft. Transcriptome analysis of UR214-9 exposed cells demonstrated significant perturbation of <20 genes compared to afatinib which impacted >1200 genes in JIMT-1 breast cancer cells indicating target specificity and non-transcriptional functions of UR214-9. In summary, disrupting septins via UR214-9 is a new approach to control the growth of HER2+ malignancies.