bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunophenotypic Detection of Measurable Residual (Stem Cell) Disease Using LAIP Approach in Acute Myeloid Leukemia
Authors: Zeijlemaker Wendelien , Kelder Angele , Cloos Jacqueline , Schuurhuis Gerrit Jan 
Published: October 2019

AbstractHalf of the patients with acute myeloid leukemia (AML), who achieve complete remission after chemotherapy treatment, will ultimately experience a relapse. Measurable residual disease (MRD) is an important post‐treatment risk factor in AML, because it gives additional information about the depth of the remission. Within MRD, the small population of leukemic stem cells (LSCs) is thought to be at the base of the actual relapse. In this protocol, the flow cytometric detection of MRD and LSCs herein is outlined. We give a detailed overview of the sampling procedures for optimal multiparameter flow cytometry assessment of both MRD and LSC, using leukemia associated immunophenotypes (LAIPs) and LSC markers. Moreover, an overview of the gating strategies to detect LAIPs and LSC markers is provided. This protocol serves as guidance for flow cytometric detection of measurable residual (stem cell) disease necessary for proper therapeutic decision making in AML patients. © 2019 The Authors.Basic Protocol 1: Immunophenotypic LAIP detection for measurable residual disease monitoringBasic Protocol 2: Immunophenotypic detection of CD34+CD38− leukemic stem cells
Retracted: Multiscale fast correlation filtering tracking algorithm based on a feature fusion model
Authors: Chen Yuantao , Wang Jin , Liu Songjie , Chen Xi , Xiong Jie , Xie Jingbo , Yang Kai 
Published: October 2019

SummaryRetraction: Multiscale fast correlation filtering tracking algorithm based on a feature fusion model Yuantao Chen, Jin Wang, Songjie Liu, Xi Chen, Jie Xiong, Jingbo Xie, Kai Yang, 2021, 33 (15), (https://doi.org/10.1002/cpe.5533
Search for New Molybdenum‐Based Crystal Scintillators for the Neutrino‐Less Double Beta Decay Search Experiment
Authors: Kim HongJoo , Pandey Indra Raj , Khan Arshad , Son Ju‐Kyung , Lee Moo Hyun , Kim Yeongduk 
Published: October 2019

AbstractStudies of Li2O–MoO3, Cs2MoO4–MoO3, and Na2O–MoO3 phases have helped us to develop several new crystals such as Li2MoO4, Li4Mo5O17, Li2Mo4O13 Cs2MoO4, Cs2Mo2O7, Cs2Mo3O10 Na2Mo2O7, and Na6Mo11O36 grown by a Czochralski method. Syntheses of the polycrystalline materials are discussed based on the thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC) analysis and the crystals’ structures are reported based on the X‐ray powder diffraction (XRD) analysis. Luminescence properties of the crystals from room temperature to 10 K are studied by exciting the crystal with a 280 nm light emitting diode (LED). The scintillation light yields of the crystals at different low temperatures are studied by exciting the crystal with strontium‐90 (90Sr) beta source. The developed crystals are not luminescent at room temperature. At cryogenic temperature, however, they become luminescent with longer decay times. This work also reports on the luminescence and scintillation properties of ZnMoO4, PbMoO4, Pb2MoO5, and CaMoO4 crystals which have been grown at other institutes. The newly developed crystals’ results are compared with the result of a standard CaMoO4 crystal. Among the new Mo‐based crystals, the Na2Mo2O7 crystal shows the most promising properties for the neutrino‐less double beta decay (0νββ) search experiments at cryogenic temperature.
Reflective structured dialogue: A qualitative thematic analysis
Authors: Gower Katherine , Cornelius Llewellyn , Rawls Raye , Walker Brandy B. 
Published: October 2019

AbstractReflective Structured Dialogue (RSD) is a specific type of dialogue intervention designed to help individuals on opposing sides of controversial political and social issues share their perspectives, and communicate in a manner that allows them to better understand one another. The current study examined outcomes from case studies on RSD using qualitative thematic analysis. Eight articles were analyzed, using an inductive grounded theory approach. The major themes that emerged were embracing multiple perspectives, positions of power, stronger/more positive connections, better communication, personal growth/self‐reflection, and challenges/limitations. Implications, recommendations, and suggestions for future research are discussed.
Branched Bio‐Lubricant Base Oil Production through Aldol Condensation
Authors: Norton Angela M. , Liu Sibao , Saha Basudeb , Vlachos Dionisios G. 
Published: October 2019

AbstractInvited for this month′s cover is the group of Dionisios G. Vlachos at the Catalysis Center for Energy Innovation, University of Delaware. The cover design shows the application of renewable feedstocks to make a lubricant base oil that can be used in a racecar. The Full Paper itself is available at 10.1002/cssc.201901838.
Glyco‐metabolic control, inflammation markers, and cardiovascular outcomes in type 1 and type 2 diabetic patients on insulin pump or multiple daily injection (italico study)
Authors: Derosa Giuseppe , Catena Gabriele , Scelsi Laura , D'Angelo Angela , Raddino Riccardo , Cosentino Eugenio , Maggi Antonio , Pasini Gianfranco , Borghi Claudio , Maffioli Pamela 
Published: October 2019

AbstractBackgroundTo evaluate if the positive effects recorded on glycaemic control with continuous subcutaneous insulin infusion (CSII) were maintained on the long‐term compared with multiple daily injection (MDI). The secondary objective was to evaluate if there is a reduction of type and number of cardiovascular events (CV).MethodsThis retrospective, observational study evaluated glycaemic control and the number of CV in 104 patients with type 1 or 2 diabetes previously treated with MDI and initiating CSII therapy with tubed insulin pumps compared with 109 patients previously treated with MDI continuing MDI.ResultsAfter 8 years, the glycaemic control including glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), and prandial plasma glucose (PPG) improved with both CSII and MDI compared with baseline; however, HbA1c, FPG, and PPG recorded with CSII were lower than data recorded with MDI. During the 8 years, there were fewer CV events with CSII, compared with MDI, and in particular, there were fewer cases of atrial fibrillation, premature ventricular contractions, acute coronary infarction, angina pectoris, heart failure, and peripheral vascular ischemia. We did not record any reduction of ischemic stroke events.ConclusionOur preliminary data suggest that CSII treatment seems to reduce the rates of CV compared with MDI therapy. Moreover, CSII also improved glycaemic control, without increasing the number of hypoglycaemia. However, given the observational design of this trial, our data should be validated in a randomized clinical trial; if they will be confirmed, CSII could be chosen for fully informed and motivated patients at higher risk of developing CV.
Most women with anorexia nervosa report less eating pathology on days when they are more self‐compassionate than usual
Authors: Kelly Allison C. , Waring Sydney V. , Dupasquier Jessica R. 
Published: October 2019

AbstractObjectiveIndividuals with eating disorders who have lower trait levels of self‐compassion have more severe eating pathology. This study examined the extent to which levels of self‐compassion fluctuate day‐to‐day in individuals with anorexia nervosa (AN) and whether these fluctuations contribute to their eating pathology.MethodFor 2 weeks, 33 women with typical (75%) and atypical AN reported on their daily eating pathology and self‐compassion.ResultsNearly half the variance in participants' self‐compassion scores occurred at the within‐persons daily level. Multilevel modeling revealed that on days when participants were more self‐compassionate than usual, their eating pathology was lower. However, this effect was moderated by participants' mean self‐compassion level over the 2 weeks. Specifically, daily self‐compassion was negatively related to eating pathology among individuals with average and higher mean self‐compassion levels but was not related to eating pathology among those with lower levels.DiscussionOne‐time self‐reports of self‐compassion in individuals with AN may overlook the substantial within‐person variability in their self‐compassion levels. For most individuals with AN, responding to distressing daily experiences with more compassion than usual should be associated with decreased eating pathology. More work is needed to understand how individuals lower in dispositional self‐compassion can benefit from these upward fluctuations.
Conductivity analysis of hydraulic fractures filled with nonspherical proppants in tight oil reservoir
Authors: Xu Jiaxiang , Ding Yunhong , Yang Lifeng , Liu Zhe , Gao Rui , Yang Hanxuan , Wang Zhen 
Published: October 2019

AbstractHydraulic fracturing is an effective way to exploit hydrocarbons in tight oil reservoir. The success of this technique lies on the creation of high conductivity channels for the oil and gas. Quantitative analysis of factors influencing the conductivity of propped fractures is significant for the design of the operation schedule. According to the definition of sphericity, cylindrical and planar proppants of different sphericity and sizes were presented. And disordered packs of nonspherical proppants in fractures of different widths were established by the discrete element method. The change of the proppant embedment and fracture width under different closure pressures were analyzed by the solid mechanics. During the fracture deformation, the pressure and velocity of the fluid flowing in fractures were simulated by Lattice‐Boltzmann method. Based on that, the effect of the proppant size, sphericity, and the fracture width on the permeability and conductivity of hydraulic fractures were investigated. The accuracy of the model was verified by the experimental data. The simulation results show that the fracture permeability and conductivity decrease with the decrease in the rock's Young's modulus, proppant size, and sphericity, and their stress sensitivity increases with the decrease in the rock's Young's modulus and the increase in the proppant size. Increasing fracture width can improve fracture conductivity more significantly than increasing fracture permeability. The permeability and conductivity of the fractures filled cylindrical proppants are higher than that of the fractures filled with planar proppants.
Feasibility of Hydrogen Compression in an Electrochemical System: Focus on Water Transport Mechanisms
Authors: Sdanghi G. , Dillet J. , Didierjean S. , Fierro V. , Maranzana G. 
Published: October 2019

AbstractIn this study, the behavior of an electrochemical hydrogen compressor (EHC) able to compress hydrogen up to 32 bar was investigated. The current density distribution along the EHC was measured using a segmented cell. It was found to decrease from 0.75 A cm−2 to 0.65 A cm−2 along the EHC when using Nafion 117 and when high relative humidity hydrogen was fed to the EHC (at 0.66 A cm−2 and 0.36 V). This drop corresponded to a decrease of the relative humidity of the hydrogen flow from 90 to 55% along the gas channels at the anode side, evidencing the local dehydration of the PEM due to the unbalanced water transport across the membrane. As a consequence, the membrane resistance increased, thus a higher voltage had to be supplied to the EHC in order to maintain good performances, decreasing the overall efficiency. On the other hand, unstable operating conditions were observed when using hydrogen with a low relative humidity.A pseudo‐2D model was developed along with experimental studies to estimate the physical parameters enhancing the efficiency of the EHC. A higher efficiency was obtained when using a thinner membrane than Nafion 117 (53% vs. 37%, at 60 °C and 0.66 A cm−2).
Suicidal ideation is common in autosomal dominant Alzheimer's disease at‐risk persons
Authors: Ng Kok Pin , Richard‐Devantoy Stéphane , Bertrand Josie‐Anne , Jiang Lai , Pascoal Tharick A. , Mathotaarachchi Sulantha , Therriault Joseph , Yatawara Chathuri , Kandiah Nagaendran , Greenwood Celia M.T. , Rosa‐Neto Pedro , Gauthier Serge ,   Dominantly Inherited Alzheimer Network
Published: October 2019

ObjectivesTo study the frequency of suicidal ideation and its association with clinical and neurobiological correlates among cognitively intact autosomal dominant Alzheimer's disease (ADAD) at‐risk individuals.Methods/DesignIn a cross‐sectional study of 183 ADAD at‐risk individuals (91 mutation carriers and 92 noncarriers), we compared the frequency of suicidal ideation among carriers and noncarriers. Linear mixed‐effects models with family‐level random effects evaluated the relationships between geriatric depression scale (GDS), neuropsychiatric inventory‐questionnaire (NPI‐Q), and suicidal ideation scores among all ADAD at‐risk individuals. An interaction term was added to the regression models to evaluate the interactions of suicidal ideation and mutation status on neuropsychiatric symptoms.ResultsTwenty‐six (14.20%) ADAD at‐risk individuals (13 [14.28%] carriers and 13 [14.13%] noncarriers) had suicidal ideation. The frequency of suicidal ideation did not differ between carriers and noncarriers. Suicidal ideation was associated with higher GDS among all ADAD at‐risk individuals. When stratified into mutation carrier status, noncarriers with suicidal ideation had higher GDS than carriers. There was no statistically significant association between suicidal ideation and NPI‐Q among ADAD at‐risk individuals. Awareness of mutation status, neuropsychological performances, and cerebrospinal fluid AD biomarkers were not associated with suicidal ideation among carriers and noncarriers.ConclusionsSuicidal ideation is common among cognitively intact ADAD at‐risk individuals. While ADAD at‐risk individuals with suicidal ideation have greater depressive symptoms, noncarriers with suicidal ideation have higher GDS scores than carriers. Interestingly, awareness of the mutation status was not associated with suicidal ideation in our study. Early identification of suicidal thoughts can facilitate timely interventions to prevent suicidal behaviours.Keywords autosomal dominant Alzheimer's diseasedominantly inherited Alzheimer's networkneuropsychiatric symptomssuicidal ideation
Polysiloxanes Modified by Thiol‐Ene Reaction and Their Interaction with Gold Nanoparticles
Authors: Lemonier Stéphane , Marty Jean‐Daniel , Fitremann Juliette 
Published: October 2019

AbstractA poly(vinylmethyl‐co‐dimethyl)siloxane has been functionalized with phenylethanethiol, N‐methylmercaptoacetamide and heptadecafluoro‐1‐decanethiol by a thermal radical thiol‐ene reaction initiated by azobisisobutyronitrile. The resulting polymers were obtained in good yields with most of the time a complete conversion of the vinyl groups. The reaction also preserved the fragile polysiloxane backbone. The polymer, grafted with about 25 % of mercapto‐acetamide groups is soluble in polar solvents such as dimethylformamide and dimethyl sulfoxide, opening the way for further functionalization with polar molecules such as unprotected carbohydrates. Spherical and branched gold nanoparticles were coated with these polymers. This coating induced a surface resonance plasmon shift resulting from the interaction of the grafted polysiloxanes with the nanoparticle surface. The shift can be explained by the variation of the refractive index of the side groups but may be also related to the self‐organization of polysiloxanes and their interactions with the gold surface depending on their polarity.
Decellularized liver matrix as substrates for rescue of acute hepatocytes toxicity
Authors: Hou Yung‐te , Hsu Shan‐hui , Lee Kuang‐Min 
Published: October 2019

AbstractMore and more scholars regard the lesion of liver cirrhosis as a series of progressive clinical stages. Besides, liver cirrhosis is a late stage of scarring (fibrosis) of the liver, and has long been a common cause of death for the global adult population, thus, the treatment of liver cirrhosis is a key point investigated in the biomedical field. Here, we propose a novel hypothesis; if decellularized liver matrix (DLM) is possible injected into the injurant‐induced fiberized liver via the hepatic portal vein to thoroughly repair the liver, it may be an effective therapeutic method for liver fibrosis or even liver cirrhosis. This study mixed rat DLM with gelatin‐hydroxyphenylpropionic acid (Glt‐HPA) to form a three‐dimensional structure to simulate the in vivo liver environment, and cultured the primary rat hepatocytes in it. Afterward, the hepatocytes were treated using D‐galactosamine (GaIN), CHCl3, and CCl4‐containing medium to simulate the toxin‐mediated liver fibrosis in vitro. Finally, they were cultured in a DLM‐containing medium to observe the viability and functions of the damaged hepatocytes, and the hypothesis of this research was proved, meaning that Glt‐HPA‐DLM acting on damaged hepatocytes may repair them. Results have shown that Glt‐HPA‐DLM was effective for hepatocytes culture and repaired injured hepatocytes from GaIN, CHCl3, and CCl4 (albumin synthesis was increased by 219, 108, and 12%, respectively, whereas relative lactate dehydrogenase activity was reduced by 38, 68, and 67%, after 5 days of culture, separately). This research shows promising effects against hepatic fibrosis and may have potential for liver cirrhosis in vivo.
HR-pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta-Analysis
Authors: Mikolajewicz Nicholas , Bishop Nick , Burghardt Andrew J , Folkestad Lars , Hall Anthony , Kozloff Kenneth M , Lukey Pauline T , Molloy-Bland Michael , Morin Suzanne N , Offiah Amaka C , Shapiro Jay , van Rietbergen Bert , Wager Kim , Willie Bettina M , Komarova Svetlana V , Glorieux Francis H 
Published: October 2019

ABSTRACT
High-resolution peripheral quantitative computed tomography (HR-pQCT) is a noninvasive imaging modality for assessing volumetric bone mineral density (vBMD) and microarchitecture of cancellous and cortical bone. The objective was to (1) assess fracture-associated differences in HR-pQCT bone parameters; and (2) to determine if HR-pQCT is sufficiently precise to reliably detect these differences in individuals. We systematically identified 40 studies that used HR-pQCT (39/40 used XtremeCT scanners) to assess 1291 to 3253 and 3389 to 10,687 individuals with and without fractures, respectively, ranging in age from 10.9 to 84.7 years with no comorbid conditions. Parameters describing radial and tibial bone density, microarchitecture, and strength were extracted and percentage differences between fracture and control subjects were estimated using a random effects meta-analysis. An additional meta-analysis of short-term in vivo reproducibility of bone parameters assessed by XtremeCT was conducted to determine whether fracture-associated differences exceeded the least significant change (LSC) required to discern measured differences from precision error. Radial and tibial HR-pQCT parameters, including failure load, were significantly altered in fracture subjects, with differences ranging from −2.6% (95% confidence interval [CI] −3.4 to −1.9) in radial cortical vBMD to −12.6% (95% CI −15.0 to −10.3) in radial trabecular vBMD. Fracture-associated differences reported by prospective studies were consistent with those from retrospective studies, indicating that HR-pQCT can predict incident fracture. Assessment of study quality, heterogeneity, and publication biases verified the validity of these findings. Finally, we demonstrated that fracture-associated deficits in total and trabecular vBMD and certain tibial cortical parameters can be reliably discerned from HR-pQCT-related precision error and can be used to detect fracture-associated differences in individual patients. Although differences in other HR-pQCT measures, including failure load, were significantly associated with fracture, improved reproducibility is needed to ensure reliable individual cross-sectional screening and longitudinal monitoring. In conclusion, our study supports the use of HR-pQCT in clinical fracture prediction. © 2019 American Society for Bone and Mineral Research.
IFT80 Is Required for Fracture Healing Through Controlling the Regulation of TGF-β Signaling in Chondrocyte Differentiation and Function
Authors: Liu Min , Alharbi Mohammed , Graves Dana , Yang Shuying 
Published: October 2019

ABSTRACT
Primary cilia are essential cellular organelles that are anchored at the cell surface membrane to sense and transduce signaling. Intraflagellar transport (IFT) proteins are indispensable for cilia formation and function. Although major advances in understanding the roles of these proteins in bone development have been made, the mechanisms by which IFT proteins regulate bone repair have not been identified. We investigated the role of the IFT80 protein in chondrocytes during fracture healing by creating femoral fractures in mice with conditional deletion of IFT80 in chondrocytes utilizing tamoxifen inducible Col2α1-CreER mice. Col2α1creIFT80f/f mice had smaller fracture calluses than IFT80f/f (control) mice. The max-width and max-callus area were 31% and 48% smaller than those of the control mice, respectively. Col2α1creIFT80f/f mice formed low-density/porous woven bony tissue with significantly lower ratio of bone volume, Trabecular (Tb) number and Tb thickness, and greater Tb spacing compared to control mice. IFT80 deletion significantly downregulated the expression of angiogenesis markers-VEGF, PDGF and angiopoietin and inhibited fracture callus vascularization. Mechanistically, loss of IFT80 in chondrocytes resulted in a decrease in cilia formation and chondrocyte proliferation rate in fracture callus compared to the control mice. Meanwhile, IFT80 deletion downregulated the TGF-β signaling pathway by inhibiting the expression of TGF-βI, TGF-βR, and phosphorylation of Smad2/3 in the fracture callus. In primary chondrocyte cultures in vitro, IFT80 deletion dramatically reduced chondrocyte proliferation, cilia assembly, and chondrogenic gene expression and differentiation. Collectively, our findings demonstrate that IFT80 and primary cilia play an essential role in fracture healing, likely through controlling chondrocyte proliferation and differentiation, and the TGF-β signaling pathway. © 2019 American Society for Bone and Mineral Research.