bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectral and Anatomical Patterns of Large-Scale Synchronization Predict Human Attentional Capacity
Authors: Rouhinen Santeri , Siebenhühner Felix , Palva J Matias , Palva Satu 
Published: April 2020

AbstractThe capacity of visual attention determines how many visual objects may be perceived at any moment. This capacity can be investigated with multiple object tracking (MOT) tasks, which have shown that it varies greatly between individuals. The neuronal mechanisms underlying capacity limits have remained poorly understood. Phase synchronization of cortical oscillations coordinates neuronal communication within the fronto-parietal attention network and between the visual regions during endogenous visual attention. We tested a hypothesis that attentional capacity is predicted by the strength of pretarget synchronization within attention-related cortical regions. We recorded cortical activity with magneto- and electroencephalography (M/EEG) while measuring attentional capacity with MOT tasks and identified large-scale synchronized networks from source-reconstructed M/EEG data. Individual attentional capacity was correlated with load-dependent strengthening of theta (3–8 Hz), alpha (8–10 Hz), and gamma-band (30–120 Hz) synchronization that connected the visual cortex with posterior parietal and prefrontal cortices. Individual memory capacity was also preceded by crossfrequency phase–phase and phase–amplitude coupling of alpha oscillation phase with beta and gamma oscillations. Our results show that good attentional capacity is preceded by efficient dynamic functional coupling and decoupling within brain regions and across frequencies, which may enable efficient communication and routing of information between sensory and attentional systems.
Beneficial Effects of Cannabis on Blood–Brain Barrier Function in Human Immunodeficiency Virus
Authors: Ellis Ronald J , Peterson Scott , Cherner Mariana , Morgan Erin , Schrier Rachel , Tang Bin , Hoenigl Martin , Letendre Scott , Iudicello Jenny 
Published: April 2020

Abstract

Background
Human immunodeficiency virus (HIV) infection leads to blood–brain barrier (BBB) dysfunction that does not resolve despite viral suppression on antiretroviral therapy (ART) and is associated with adverse clinical outcomes. In preclinical models, cannabis restores BBB integrity.

Methods
We studied persons with HIV (PWH) and HIV-negative (HIV−) individuals who had used cannabis recently. We assessed 2 biomarkers of BBB permeability: the cerebrospinal fluid (CSF) to serum albumin ratio (CSAR) and CSF levels of soluble urokinase plasminogen activator receptor (suPAR), a receptor for uPA, a matrix-degrading proteolytic enzyme that disrupts the BBB. A composite index of the BBB markers was created using principal components analysis. Neural injury was assessed using neurofilament light (NFL) in CSF by immunoassay.

Results
Participants were 45 PWH and 30 HIV− individuals of similar age and ethnicity. Among PWH, higher CSF suPAR levels correlated with higher CSAR values (r = 0.47, P &lt; .001). PWH had higher (more abnormal) BBB index values than HIV− individuals (mean ± SD, 0.361 ± 1.20 vs −0.501 ± 1.11; P = .0214). HIV serostatus interacted with cannabis use frequency, such that more frequent use of cannabis was associated with lower BBB index values in PWH but not in HIV− individuals. Worse BBB index values were associated with higher NFL in CSF (r = 0.380, P = .0169).

Conclusions
Cannabis may have a beneficial impact on HIV-associated BBB injury. Since BBB disruption may permit increased entry of toxins such as microbial antigens and inflammatory mediators, with consequent CNS injury, these results support a potential therapeutic role of cannabis among PWH and may have important treatment implications for ART effectiveness and toxicity.
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options
Authors: Guzik Tomasz J , Mohiddin Saidi A , Dimarco Anthony , Patel Vimal , Savvatis Kostas , Marelli-Berg Federica M , Madhur Meena S , Tomaszewski Maciej , Maffia Pasquale , D’Acquisto Fulvio , Nicklin Stuart A , Marian Ali J , Nosalski Ryszard , Murray Eleanor C , Guzik Bartlomiej , Berry Colin , Touyz Rhian M , Kreutz Reinhold , Wang Dao Wen , Bhella David , Sagliocco Orlando , Crea Filippo , Thomson Emma C , McInnes Iain B 
Published: April 2020

AbstractThe novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and mechanistic considerations for future therapies. While COVID-19 primarily affects the lungs, causing interstitial pneumonitis and severe acute respiratory distress syndrome (ARDS), it also affects multiple organs, particularly the cardiovascular system. Risk of severe infection and mortality increase with advancing age and male sex. Mortality is increased by comorbidities: cardiovascular disease, hypertension, diabetes, chronic pulmonary disease, and cancer. The most common complications include arrhythmia (atrial fibrillation, ventricular tachyarrhythmia, and ventricular fibrillation), cardiac injury [elevated highly sensitive troponin I (hs-cTnI) and creatine kinase (CK) levels], fulminant myocarditis, heart failure, pulmonary embolism, and disseminated intravascular coagulation (DIC). Mechanistically, SARS-CoV-2, following proteolytic cleavage of its S protein by a serine protease, binds to the transmembrane angiotensin-converting enzyme 2 (ACE2) —a homologue of ACE—to enter type 2 pneumocytes, macrophages, perivascular pericytes, and cardiomyocytes. This may lead to myocardial dysfunction and damage, endothelial dysfunction, microvascular dysfunction, plaque instability, and myocardial infarction (MI). While ACE2 is essential for viral invasion, there is no evidence that ACE inhibitors or angiotensin receptor blockers (ARBs) worsen prognosis. Hence, patients should not discontinue their use. Moreover, renin–angiotensin–aldosterone system (RAAS) inhibitors might be beneficial in COVID-19. Initial immune and inflammatory responses induce a severe cytokine storm [interleukin (IL)-6, IL-7, IL-22, IL-17, etc.] during the rapid progression phase of COVID-19. Early evaluation and continued monitoring of cardiac damage (cTnI and NT-proBNP) and coagulation (D-dimer) after hospitalization may identify patients with cardiac injury and predict COVID-19 complications. Preventive measures (social distancing and social isolation) also increase cardiovascular risk. Cardiovascular considerations of therapies currently used, including remdesivir, chloroquine, hydroxychloroquine, tocilizumab, ribavirin, interferons, and lopinavir/ritonavir, as well as experimental therapies, such as human recombinant ACE2 (rhACE2), are discussed.
Age-Stage, Two-Sex Life Table of Chrysodeixis chalcites (Lepidoptera: Noctuidae) at Constant Temperatures on Semi-Synthetic Diet
Authors: del Pino Modesto , Cabello Tomás , Hernández-Suárez Estrella 
Published: April 2020

AbstractThe golden twin-spot moth or tomato looper, Chrysodeixis chalcites (Esper), is a polyphagous and worldwide pest that causes important aesthetic damages to banana fruits in the Canary Islands. The life history parameters of C. chalcites were determined under laboratory conditions in base on the age-stage, two-sex life table at 15, 20, 25, 30, and 35°C, 65% relative humidity (RH), and a photoperiod of 16:8 (L:D) h, when it was reared on a semi-synthetic diet. The results show that C. chalcites was able to develop and survive from 15 to 30°C, but no development occurred at 35°C. Developmental threshold temperatures of the egg, larval, pupal, and total preoviposition stages were 10.42, 11.73, 11.22, and 9.42°C, respectively, and their effective accumulated temperatures were 58.31, 265.96, 118.57, and 562.39 degree-days, respectively. The adult longevity was reduced with increasing temperature, which ranged between 16.27 and 34.85 d for females and between 14.27 and 35.21 d for males. The highest values of net reproductive rate (R0) and fecundity were observed at 25°C, with 232.70 offspring and 1,224.74 eggs, respectively. Both the intrinsic rate of increase (r) and finite rate of increase (λ) increased significantly and mean generation time (T) decreased significantly with increasing temperature. These results provide useful information that will allow predicting the impact of climate change on the distribution and population dynamics of C. chalcites and developing successful integrated management programs.
Timing of Communication
Authors: Bhattacharya Puja , Nielsen Kirby , Sengupta Arjun 
Published: April 2020

Abstract
Using an experiment, we demonstrate that a communication regime in which a worker communicates about his intended effort is less effective in: (i) soliciting truthful information; and (ii) motivating effort than one in which he communicates about his past effort. Our experiment uses a real-effort task, which additionally allows us to demonstrate the effects of communication on effort over time. We show that the timing of communication affects the dynamic pattern of work. In both treatments, individuals are most co-operative closest to the time of communication. Our results reveal that the timing of communication is a critical feature that merits attention in the design of mechanisms for information transmission in strategic settings.
Introducing teledermoscopy of possible skin cancers in general practice in Southern Denmark
Authors: Vestergaard Tine , Prasad Sumangali C , Schuster Annette , Laurinaviciene Rasa , Bygum Anette , Munck Anders , Andersen Merethe K 
Published: April 2020

Abstract

Background
The increasing incidence of skin cancers poses a burden to health care systems. General practitioners (GPs) play an important role in triaging these diseases and referring relevant patients to specialists. It is challenging to distinguish benign from malignant skin lesions, and GPs may benefit from diagnostic support from teledermoscopy (TD).

Objectives
To assess whether the introduction of TD in general practice was feasible and might reduce the number of unnecessary referrals to specialists and to assess the diagnostic accuracy and confidence of participating GPs.

Methods
Fifty general practices in Southern Denmark participated. Adult patients presenting to their GP with suspected skin cancer could be included. Images including dermoscopy were taken by the GP and sent for evaluation by specialized dermatologists at a university hospital. Patients were simultaneously referred for a face-to-face evaluation at the university hospital. Diagnoses proposed by the GPs and by TD were compared to the final diagnoses obtained by histopathology or, if not available, face-to-face evaluation.

Results
Five hundred and nineteen patients with 600 suspected skin cancers were included. The final diagnosis was benign in 72.3%. The photo quality was good or fair in 90.5%. GPs reported uncertainty about their diagnoses in 41.5% of cases. The GPs’ positive predictive values for any malignancy and for malignant melanoma were 49.5% and 26.3%, respectively. On evaluation by TD, 31.5% of lesions did not need further in-person assessment.

Conclusion
Useful images of suspicious skin lesions were obtained from general practice, and GPs could benefit from TD to improve their diagnostic accuracy and confidence.
Regional Gray Matter Density Associated With Fast-Paced Walking in Older Adults: A Voxel-Based Morphometry Study
Authors: Chen Nemin , Rosano Caterina , Karim Helmet T , Studenski Stephanie A , Rosso Andrea L 
Published: April 2020

Abstract

Background
Walking speed during fast-paced walking task has been associated with cognitive function. It is unclear what underlying brain structures are related to fast-paced walking. We investigated the association of gray matter (GM) density with fast-paced walking speed and usual-paced walking speed.

Methods
We collected data from 284 older adults from a subset of the Health, Aging, and Body composition study (mean age = 83 [SD = 2.8], 58% women, 41% black). Voxel-wise analyses on magnetic resonance imaging data identified regions of the brain where GM density was associated with fast-paced walking speed. We then extracted GM density for all identified regions and modeled the association with fast-paced walking speed after adjusting for demographic factors, clinical factors, and cognitive function. Analyses were repeated for usual-paced walking. Regions with beta coefficients ≥0.3 m/s were considered to be meaningfully correlated.

Results
GM density of clusters from cortical regions in the right middle and superior frontal gyrus, right postcentral gyrus, and left superior temporal gyrus were positively correlated with fast-paced walking speed in adjusted models. Adjustment for cognitive function had little impact on the findings. Caudate was correlated with usual paced walking speed at coefficient ≥0.3 m/s after adjustment of demographic factors and clinical factors, but not after further adjustment of cognitive function.

Conclusions
Fast-paced walking speed was correlated with GM density of right middle and superior frontal gyrus, right postcentral gyrus, and left superior temporal gyrus, and could potentially provide evidence about subclinical structural change of brain related to aging.
Multidimensional penalized splines for incidence and mortality-trend analyses and validation of national cancer-incidence estimates
Authors: Uhry Zoé , Chatignoux Edouard , Dantony Emmanuelle , Colonna Marc , Roche Laurent , Fauvernier Mathieu , Defossez Gautier , Leguyader-Peyrou Sandra , Monnereau Alain , Grosclaude Pascale , Bossard Nadine , Remontet Laurent 
Published: April 2020

AbstractBackgroundCancer-incidence and mortality-trend analyses require appropriate statistical modelling. In countries without a nationwide cancer registry, an additional issue is estimating national incidence from local-registry data. The objectives of this study were to (i) promote the use of multidimensional penalized splines (MPS) for trend analyses; (ii) estimate the national cancer-incidence trends, using MPS, from only local-registry data; and (iii) propose a validation process of these estimates.MethodsWe used an MPS model of age and year for trend analyses in France over 1990–2015 with a projection up to 2018. Validation was performed for 22 cancer sites and relied essentially on comparison with reference estimates that used the incidence/health-care ratio over the period 2011–2015. Alternative estimates that used the incidence/mortality ratio were also used to validate the trends.ResultsIn the validation assessment, the relative differences of the incidence estimates (2011–2015) with the reference estimates were &lt;5% except for testis cancer in men and &lt; 7% except for larynx cancer in women. Trends could be correctly derived since 1990 despite incomplete histories in some registries. The proposed method was applied to estimate the incidence and mortality trends of female lung cancer and prostate cancer in France.ConclusionsThe validation process confirmed the validity of the national French estimates; it may be applied in other countries to help in choosing the most appropriate national estimation method according to country-specific contexts. MPS form a powerful statistical tool for trend analyses; they allow trends to vary smoothly with age and are suitable for modelling simple as well as complex trends thanks to penalization. Detailed trend analyses of lung and prostate cancers illustrated the suitability of MPS and the epidemiological interest of such analyses.
Clinical and Clinical-Pharmacogenetic Models for Prediction of the Most Common Psychiatric Complications Due to Dopaminergic Treatment in Parkinson’s Disease
Authors: Redenšek Sara , Jenko Bizjan Barbara , Trošt Maja , Dolžan Vita 
Published: April 2020

AbstractBackgroundThe most common psychiatric complications due to dopaminergic treatment in Parkinson’s disease are visual hallucinations and impulse control disorders. Their development depends on clinical and genetic factors.MethodsWe evaluated the simultaneous effect of 16 clinical and 34 genetic variables on the occurrence of visual hallucinations and impulse control disorders. Altogether, 214 Parkinson’s disease patients were enrolled. Their demographic, clinical, and genotype data were obtained. Clinical and clinical-pharmacogenetic models were built by The Least Absolute Shrinkage and Selection Operator penalized logistic regression. The predictive capacity was evaluated with the cross-validated area under the receiver operating characteristic curve (AUC).ResultsThe clinical-pharmacogenetic index for prediction of visual hallucinations encompassed age at diagnosis (OR = 0.99), rapid eye movement (REM) sleep behavior disorder (OR = 2.27), depression (OR = 1.0002), IL6 rs1800795 (OR = 0.99), GPX1 s1050450 (OR = 1.07), COMT rs165815 (OR = 0.69), MAOB rs1799836 (OR = 0.97), DRD3 rs6280 (OR = 1.32), and BIRC5 rs8073069 (OR = 0.94). The clinical-pharmacogenetic index for prediction of impulse control disorders encompassed age at diagnosis (OR = 0.95), depression (OR = 1.75), beta-blockers (OR = 0.99), coffee consumption (OR = 0.97), NOS1 rs2682826 (OR = 1.15), SLC6A3 rs393795 (OR = 1.27), SLC22A1 rs628031 (OR = 1.19), DRD2 rs1799732 (OR = 0.88), DRD3 rs6280 (OR = 0.88), and NRG1 rs3924999 (OR = 0.96). The cross-validated AUCs of clinical and clinical-pharmacogenetic models for visual hallucinations were 0.60 and 0.59, respectively. The AUCs of clinical and clinical-pharmacogenetic models for impulse control disorders were 0.72 and 0.71, respectively. The AUCs show that the addition of selected genetic variables to the analysis does not contribute to better prediction of visual hallucinations and impulse control disorders.ConclusionsModels could be improved by a larger cohort and by addition of other types of Parkinson’s disease biomarkers to the analysis.
The Affective Foundation of Political Opinion Expression on Social Media: A Panel Analysis
Authors: Heiss Raffael 
Published: April 2020

AbstractSocial media (SM) allow citizens to not only read news but also express their political opinions. Drawing from cognitive appraisal and affective intelligence theory, this study investigated the affective foundation of political opinion expression on social media (POESM) using two-wave panel data. The results indicate that enthusiasm and anger stimulated POESM but only for individuals with a minimum threshold motivation to use SM for political purposes. Among the politically motivated, anxiety increased POESM for individuals with low political knowledge but lessened POESM for ones with high political knowledge. Thus, emotional states can be powerful drivers of POESM. In contexts with low levels of POESM, emotions may stimulate online discussion as well as contribute to the further emotionalization of political debates.
In vitro susceptibility to fostemsavir is not affected by long-term exposure to antiviral therapy in MDR HIV-1-infected patients
Authors: Saladini Francesco , Giannini Alessia , Giammarino Federica , Maggiolo Franco , Vichi Francesca , Corbelli Giulio M , Galli Andrea , Bigoloni Alba , Poli Andrea , Santoro Maria M , Zazzi Maurizio , Castagna Antonella 
Published: April 2020

Abstract

Objectives
Fostemsavir is the prodrug of the HIV-1 attachment inhibitor temsavir and is currently under clinical assessment in heavily treatment-experienced patients with limited therapeutic options. We evaluated the genotypic and phenotypic susceptibility to temsavir in a panel of samples collected from patients harbouring MDR strains enrolled in the Italian PRESTIGIO Registry.

Methods
Plasma samples from 24 patients were used for HIV-1 gp120 sequencing, while viral tropism and susceptibility to temsavir were assessed through a homemade phenotypic assay with pseudotyped viruses expressing patient-derived Env protein.

Results
Of the 24 patients enrolled, 18 (75%) were male, median (IQR) age was 55 years (52–61), time since HIV-1 diagnosis was 27 years (24–30), time on ART was 26 years (23–27) and 11 (46%) had a previous AIDS diagnosis. Exposure to entry inhibitors (maraviroc and/or enfuvirtide) had occurred in 19 (79%) patients. Among 23/24 gp120 sequences obtained, temsavir resistance-associated mutations (RAMs) were detected in three cases (two M426L and one S375N). Pseudotyped viruses were obtained from 23/24 samples and viral tropism was CXCR4-tropic, CCR5-tropic and dual/mixed-tropic in six, nine and eight cases, respectively. Phenotypic susceptibility to temsavir was comparable to the reference WT viruses NL4-3 and AD8 in all samples, irrespective of RAMs. Viral tropism and exposure to entry inhibitors did not impact temsavir susceptibility.

Conclusions
These data support the use of fostemsavir as a valuable therapy option in patients harbouring MDR virus. The role of laboratory testing in optimal screening of patients eligible for fostemsavir treatment remains to be investigated.
Public health reporting and outbreak response: synergies with evolving clinical standards for interoperability
Authors: Mishra Ninad K , Duke Jon , Lenert Leslie , Karki Saugat 
Published: April 2020

Abstract
Public health needs up-to-date information for surveillance and response. As healthcare application programming interfaces become widely available, a novel data gathering mechanism could provide public health with critical information in a timely fashion to respond to a fast-moving epidemic. In this article, we extrapolate from our experiences using a Fast Healthcare Interoperability Resource-based architecture for infectious disease surveillance for sexually transmitted diseases to its application to gather case information for an outbreak. One of the challenges with a fast-moving outbreak is to accurately assess its demand on healthcare resources, since information specific to comorbidities is often not available. These comorbidities are often associated with poor prognosis and higher resource utilization. If the comorbidity data and other clinical information were readily available to public health workers, they could better address community disruption and manage healthcare resources. The use of FHIR resources available through application programming and filtered through tools such as described herein will give public health the flexibility needed to investigate rapidly emerging disease while protecting patient privacy.
Development of the Gender, Sex, and Sexual Orientation ontology: Evaluation and workflow
Authors: Kronk Clair A , Dexheimer Judith W 
Published: April 2020

Abstract

Objective
The study sought to create an integrated vocabulary system that addresses the lack of standardized health terminology in gender and sexual orientation.

Materials and Methods
We evaluated computational efficiency, coverage, query-based term tagging, randomly selected term tagging, and mappings to existing terminology systems (including ICD (International Classification of Diseases), DSM (Diagnostic and Statistical Manual of Mental Disorders ), SNOMED (Systematized Nomenclature of Medicine), MeSH (Medical Subject Headings), and National Cancer Institute Thesaurus).

Results
We published version 2 of the Gender, Sex, and Sexual Orientation (GSSO) ontology with over 10 000 entries with definitions, a readable hierarchy system, and over 14 000 database mappings. Over 70% of terms had no mapping in any other available ontology.

Discussion
We created the GSSO and made it publicly available on the National Center for Biomedical Ontology BioPortal and on GitHub. It includes clarifications on over 200 slang terms, 190 pronouns with linked example usages, and over 200 nonbinary and culturally specific gender identities.

Conclusions
Gender and sexual orientation continue to represent crucial areas of medical practice and research with evolving terminology. The GSSO helps address this gap by providing a centralized data resource.