bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Tropical Pacific Winds Enhance the Footprint of the Interdecadal Pacific Oscillation on the Upper-Ocean Heat Content in the South China Sea?
Authors: Xiao Fuan , Wang Dongxiao , Yang Lei 
Published: March 2020

AbstractIn this study, an enhanced footprint of the interdecadal Pacific oscillation (IPO) on the upper-ocean heat content (OHC) in the South China Sea (SCS) since the 1990s is revealed. The negative OHC–IPO correlation is significant (r= −0.71) during 1990–2010 [period 2 (P2)], whereas it is statistically insignificant during 1960–80 [period 1 (P1)]. Analyses show that the scope of the equatorial Pacific wind anomalies is wider during P2 compared with that during P1 due to a larger east–west SST gradient and enhanced tropical warming in the Indian Ocean. When the IPO is negative during P2, a wider scope of the wind stress anomalies associated with the IPO could lead to 1) the southward migration of the North Equatorial Current bifurcation latitude (NECBL) by affecting the wind stress curl over the key region where it is near the climatological NECBL and 2) an increase in the interbasin pressure gradient (sea surface height difference) between the western Pacific and the SCS; these two processes strengthen the Kuroshio and weaken the Luzon Strait transport (LST) or SCS throughflow into the SCS. Also, 3) the equatorial Pacific wind anomalies are wide enough to directly weaken the LST in the SCS through the “island rule.” These three pathways finally change the oceanic gyre in the SCS and increase the OHC. Our results suggest that the scope of the tropical wind stress is the crucial factor when we consider the relationship between the upper ocean thermal conditions in the SCS and the Pacific variability.
Middle ear Pathologies in Adults Living with Human Immunodeficiency Virus: A Systematic Review
Authors: Sebothoma Ben , Khoza-Shangase Katijah 
Published: March 2020

Introduction: Middle ear pathologies have been linked with HIV. The onset and development of these pathologies in individuals with HIV have not been categorized; and clarity has not been gained regarding whether their presentation is any different in this population when compared to HIV negative control group. Purpose: The aim of this study was to explore and document published evidence reflecting trends in middle ear pathologies in adults living with HIV. Methods: A systematic review of literature from January 1982 to December 2018 was conducted using Medline, CINAHL, PubMed, and Psych Info. Studies that reported the occurrence rate of middle ear pathologies in adults with HIV and published in English were included. Results: Twelve articles met the inclusion criteria. Evidence suggests that the reported occurrence rates of middle ear pathologies ranges from 2.5% to 58% in this population. The variability in assessment measures as well as the different cut-off criteria used in studies seem to have an influence in the findings, with pure tone audiometry identifying more middle ear pathologies in the current review than tympanometry with 226 Hz probe tone and clinical examination. Otitis media, conductive hearing loss, and type B tympanogram were common findings reported in this study. No evidence of an association between the use of antiretroviral therapy (ART) and the rates of middle ear pathologies was found. Conclusion: Although there are very few studies that have reported on middle ear pathologies in adults living with HIV, the available studies have sufficiently established a link between HIV and middle ear disease in this population, and have revealed that the rate of occurrence is influenced by a number of factors. Key amongst these is the type of assessment measure used. Careful analysis of middle ear pathologies in this population through well controlled research designs that include different assessment measures. The use of case-control and longitudinal designs to determine differences between groups and to establish the time of onset and development of middle ear pathologies is required.
The Optiscope Enlarger: A Report of Initial Field Trials
Authors: Hellinger George O. , Berger Arthur W. 
Published: March 2020

□ 1. Thirty consecutively selected low vision patients were evaluated on their performance in viewing a standard near-point chart and selected materials. This was done unaided and then with their customary low-vision aid, first hand-held and then viewed in the Optiscope Enlarger. 2. All subjects demonstrated an ability to read smaller point chart type and to do so at a greater distance with the Optiscope Enlarger. Varied responses on the selected materials might be attributable to word reading difficulties or the effect of the causative defect. 3. Some subjects did better without their low-vision aids or went to distance prescription lenses while using the Optiscope Enlarger. Use of this type of device indicates the necessity for testing for greater distance than normally associated with low-vision aids. 4. Responses of the subjects were 18 favorable, five questionable, and seven negative. It was found that room illumination had to be varied in certain cases. 5. Use of this device would permit simultaneous viewing by parent and child at home, reading at more normal distances, greater word and phrase span, and the viewing of technical diagrams. 6. The results of this evaluation indicate that the Optiscope Enlarger is of substantial value and warrants further investigation.
The Auditory Quiz Board: An Orientation and Mobility Game for Visually Handicapped Elementary School Children
Authors: Bohman Richard V. , Bryan William H. , Tapp Kenneth L. 
Published: March 2020

□ The use of the AQB games has become an integral part of our program for teaching visually handicapped elementary school students cardinal directions and other basic environmental or geographical concepts preparatory to advanced orientation and mobility training. The following advantages can be noted: 1) The device is simple and inexpensive to construct. 2) It is easily adapted to print or braille. 3) It may be used as either an evaluative or a teaching tool. 4) The questions can easily be individualized to meet student or classroom needs. 5) The boards are accessible and portable and can easily be placed in classroom, library, or dormitories for individual practice. 6) The boards are easily used by elementary classroom teachers in the absence of the mobility instructor. 7) The boards can also be used with high school students. 8) The principles of this game device could easily be adapted to other areas of instruction (science, history, etc.). 9) Most importantly, the “buzz” response of the AQB is a highly motivational tool for use with visually handicapped children. As a result of the Auditory Quiz Board games, many students at the Wisconsin School for the Visually Handicapped have learned at a very early age that “orientation and mobility is fun!”
Developing Play Skills and Communicative Competence in Multiply Handicapped Young People
Authors: Rogow Sally M. 
Published: March 2020

Role play with toys was modeled to develop communicative language function in 14 multiply handicapped individuals ranging in age from 8 to 26 whose speech was characterized by echolalic and stereotypic responses. Even subjects who spoke in complete sentences asked few questions and did not use narrative speech to any significant degree. As they learned to role play, however, their communicative functioning improved and they shared referents (play themes and toy props) and cooperative social routines (role play). Play themes that were of personal interest elicited the greatest participation. Nonverbal subjects did not develop symbolic play, but they did establish communicative responses as they began to anticipate and express their preferences. No changes were noted in the verbal subjects’ syntax or vocabulary. Verbal expression increased and narrative and question forms appeared. Language behavior became more communicative and meaningful as social interaction increased.
A new genetic locus for antipsychotic-induced weight gain: A genome-wide study of first-episode psychosis patients using amisulpride (from the OPTiMiSE cohort)
Authors: ter Hark Sophie E , Jamain Stéphane , Schijven Dick , Lin Bochao D , Bakker Mark K , Boland-Auge Anne , Deleuze Jean-François , Troudet Réjane , Malhotra Anil K , Gülöksüz Sinan , Vinkers Christiaan H , Ebdrup Bjørn H , Kahn René S , Leboyer Marion , Luykx Jurjen J 
Published: March 2020

Background: Antipsychotic-induced weight gain is a common and debilitating side effect of antipsychotics. Although genome-wide association studies of antipsychotic-induced weight gain have been performed, few genome-wide loci have been discovered. Moreover, these genome-wide association studies have included a wide variety of antipsychotic compounds. Aims: We aim to gain more insight in the genomic loci affecting antipsychotic-induced weight gain. Given the variable pharmacological properties of antipsychotics, we hypothesized that targeting a single antipsychotic compound would provide new clues about genomic loci affecting antipsychotic-induced weight gain. Methods: All subjects included for this genome-wide association study ( n=339) were first-episode schizophrenia spectrum disorder patients treated with amisulpride and were minimally medicated (defined as antipsychotic use <2 weeks in the previous year and/or <6 weeks lifetime). Weight gain was defined as the increase in body mass index from before until approximately 1 month after amisulpride treatment. Results: Our genome-wide association analyses for antipsychotic-induced weight gain yielded one genome-wide significant hit (rs78310016; β=1.05; p=3.66 × 10−08; n=206) in a locus not previously associated with antipsychotic-induced weight gain or body mass index. Minor allele carriers had an odds ratio of 3.98 ( p=1.0 × 10−03) for clinically meaningful antipsychotic-induced weight gain (⩾7% of baseline weight). In silico analysis elucidated a chromatin interaction with 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1. In an attempt to replicate single-nucleotide polymorphisms previously associated with antipsychotic-induced weight gain, we found none were associated with amisulpride-induced weight gain. Conclusion: Our findings suggest the involvement of rs78310016 and possibly 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 in antipsychotic-induced weight gain. In line with the unique binding profile of this atypical antipsychotic, our findings furthermore hint that biological mechanisms underlying amisulpride-induced weight gain differ from antipsychotic-induced weight gain by other atypical antipsychotics.
Defining Variations in Outcomes of Hip Arthroscopy for Femoroacetabular Impingement Using the 12-Item International Hip Outcome Tool (iHOT-12)
Authors: Martin RobRoy L. , Kivlan Benjamin R. , Christoforetti John J. , Wolff Andrew B. , Nho Shane J. , Salvo John P. , Van Thiel Geoff , Matsuda Dean , Carreira Dominic S. 
Published: March 2020

Background: As health care moves toward a value-based payment system, it will be important that patient-reported outcome measures (PROMs) define variations in outcome over a follow-up period that allows a patient to achieve maximal improvement. Although there is evidence to support the use of PROMs to assess postoperative outcomes after hip arthroscopy, there is limited information available to assess for variations in outcome at a 2-year follow-up interval. Purpose: To identify substantial clinical benefit (SCB) and patient acceptable symptom state (PASS) cutoff scores for the 12-item International Hip Outcome Tool (iHOT-12) that define patient status across a spectrum of potential outcomes after hip arthroscopy at a 2-year follow-up interval. Study design: Cohort study (diagnosis); Level of evidence, 2. Methods: These data were collected from a research registry of patients having hip arthroscopy for femoroacetabular impingement and/or chondrolabral pathology. On initial assessment and 2 years (±2 months) postoperatively, patients completed the iHOT-12, and categorical self-rating of function. They also completed a visual analog scale of postoperative satisfaction. Receiver operator characteristic analysis was performed to determine absolute SCB iHOT-12 scores associated with an “abnormal,”“nearly normal,” or “normal” self-report of function, and PASS scores for those reporting at least 50%, at least 75%, or 100% satisfaction with their surgery. Results: Out of 723 eligible patients, 658 (91%) met the inclusion criteria. The patients consisted of 462 (70%) women and 196 (30%) men, with a mean age of 35.3 years (SD, 13 years) and mean follow-up of 722 days (SD, 69 days). Absolute SCB and PASS iHOT-12 scores ranging from 38 to 86 were accurate in identifying those who had abnormal, nearly normal, and normal self-reported function and were at least 50%, at least 75%, and 100% satisfied with surgery. The areas under the curve were >0.70, with sensitivity and specificity values ranging from 0.78 to 0.92. Conclusion: This study provides absolute SCB and PASS iHOT-12 cutoff scores that can be used to define variations in 2-year (±2 months) outcomes in patients after hip arthroscopy for femoroacetabular impingement and chondrolabral pathology. iHOT-12 scores of 38, 60, and 86 were associated with abnormal, nearly normal, and normal reports of function respectively, with scores of 60, 71, and 86 associated with at least 50%, at least 75%, and 100% satisfaction after surgery, respectively.
Using Escape Rooms for Conducting Team Research: Understanding Development, Considerations, and Challenges
Authors: Cohen Tara N. , Griggs Andrew C. , Keebler Joseph R. , Lazzara Elizabeth H. , Doherty Shawn M. , Kanji Falisha F. , Gewertz Bruce L. 
Published: March 2020

Background. Modern organizations are increasingly reliant on teams, and many organizations are subsequently concerned with the development of interventions that can improve the performance of teams. Escape rooms are beginning to receive attention as a potential avenue to facilitate team-based research. Escape rooms are team-based recreational activities that require a team of individuals to work together and think critically in order to solve a series of puzzles or challenges to escape a room. Purpose. This article provides considerations for researchers and organizations alike concerning the development of an escape room for team-based research, its methodological applications, and challenges associated with the use of escape rooms in research. Developmental considerations include issues such as an escape room’s location and size, financial considerations, theme development, other characteristics of the escape room, the development of puzzles and challenges, prototyping efforts, and the development of hints. Conclusion. Research considerations include the use of observational and survey methods in data collection, measurement of team processes and team performance, and how elements of an escape room influence teamwork and problem solving. Various challenges associated with the use of escape rooms in team-based research include considerations for dealing with cheating behavior, providing hints to participants, and resetting the room between experimental trials.
Effect of Severity of Deformity on Clinical Outcomes of Scarf Osteotomies
Authors: Law Gin Way , Tay Kae Sian , Lim Jeremy Wei Sern , Zhang Karen Ting , Seng Chusheng , Yeo Nicholas Eng Meng , Koo Kevin , Rikhraj Inderjeet Singh 
Published: March 2020

Background: Literature is sparse on whether severity of hallux valgus affects outcomes of surgery. We thus aimed to evaluate the impact of hallux valgus severity on the clinical outcomes of surgery. Methods: 83 consecutive scarf osteotomies performed by a single surgeon for symptomatic hallux valgus between 2007 and 2011 were divided into 3 groups (mild, moderate, and severe) based on severity of their preoperative hallux valgus using the hallux valgus and intermetatarsal angles. Outcomes were assessed using the visual analog scale (VAS) for pain, 36-Item Short Form Health Survey physical functioning (SFPF) and mental health (SFMH) subscales, and American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scores. These were assessed preoperatively and at 6 months and 2 years postoperatively. Patient satisfaction was assessed at 6 months and 2 years postoperatively. Eleven (13.2%), 54 (65.1%), and 18 (21.7%) feet were in the mild, moderate, and severe groups, respectively. Results: There was no difference in preoperative VAS, SFPF, SFMH and AOFAS scores between the groups except for AOFAS scores for the second toe, which were poorer with increasing hallux valgus. Postoperatively, there was improvement across all outcome scores. VAS and AOFAS showed excellent scores, and patient satisfaction was high across all 3 groups (88.9%, 89.4%, and 86.7%). The severe group had slightly lower SFPF scores at 6 months (mild, 81.1; moderate, 84.0; severe, 74.3; P = .031) and 2 years postoperatively (mild, 93.4; moderate, 89.7; severe, 76.4; P = .005), and slightly poorer second toe scores for VAS (mild, 0.0; moderate, 0.1; severe, 1.2; P = .017) and AOFAS (mild, 94.7; moderate, 93.5; severe, 83.4; P = .043) at 2 years postoperatively. All other scores including patient satisfaction showed no between-group differences. Complication and revision rates between the groups were similar. Conclusion: Surgery for symptomatic hallux valgus lead to excellent outcomes and high patient satisfaction regardless of severity of deformity. Level of Evidence: Level III, comparative series.
Comparison of accuracy of cup position using portable navigation versus alignment guide in total hip arthroplasty in supine position
Authors: Okamoto Masanori , Kawasaki Masashi , Okura Toshiaki , Ochiai Satoshi , Yokoi Hiroyuki 
Published: March 2020

Background: Accelerometer-based portable navigation systems in supine total hip arthroplasty (THA) have been developed, but there are no reports on the accuracy of cup placement. We aimed to investigate and compare the accuracy of the accelerometer-based portable navigation system versus the acetabular alignment guide placed on the pelvis in THA using the direct anterior approach (DAA). Both devices tracked changes in the pelvic position. Methods: In this single-centre, retrospective study, we reviewed 115 hips in 113 patients who underwent primary THA via the DAA using an accelerometer-based portable navigation system in the supine position (portable navigation group) and 106 hips in 101 patients who underwent THA using an acetabular alignment guide (alignment guide group) as controls. Hips were evaluated postoperatively using computed tomography to measure cup orientation. The accuracy of cup orientation was compared between the 2 groups. Results: Absolute values of inclination error were 3.1° ± 2.2° and 2.9° ± 2.3° ( p = 0.708) in the portable navigation and alignment guide groups and those of anteversion error were 2.8° ± 2.3° and 3.7° ± 2.7°, respectively ( p = 0.005). The number of cups placed within 10° of error was 98.3% and 96.2% in the portable navigation and alignment guide groups, respectively ( p = 0.304). The portable navigation group had significantly more hips (72.2%) placed within a 5° margin of error than did the alignment guide group (56.6%) ( p = 0.016). Conclusion: High accuracy in cup placement was achieved using accelerometer-based portable navigation in supine THA. Using a navigation system may contribute to improved long-term outcomes.
Validity of clinical methods in the detection of leg-length discrepancies
Authors: Gomez-Aguilar Estela , Reina-Bueno Maria , Lafuente-Sotillos Guillermo , Montes-Salas Ruben , Munuera-Martinez Pedro V , Castillo-Lopez Jose M 
Published: March 2020

Introduction: Lower limb-length discrepancy is highly prevalent in the general population. Numerous methods and measurement instruments for its diagnosis appear in the literature, but there has not been an agreement about their validity. The aim of this work is to determine the validity of the Weber-Barstow manoeuvre (WB) of the pelvic measuring device (PMD) and the block method (BM), in comparison with standing anteroposterior telemetry of the lower limbs in subjects with leg-length discrepancy (LLD). Methods: 71 subjects took part in the study. First, the WB was carried out in the supine position. the LLD was then quantified standing with the PMD and with the BM. Lastly, standing anteroposterior telemetry of the lower limbs was obtained. This was measured with Autocad 2013, using the highest part of the head of the femur and the most distal edge of the bisection of the femur as points of reference. Results: The Kappa index was calculated to check the agreement between the WB manoeuvre and the telemetry. This was 0.52. The relation of the PMD, BM and telemetry difference variables was calculated. A direct relation between the BM and telemetry was shown, with p > 0.05 (0.48 cm and 0.51 cm, respectively). Conclusions: The WB manoeuvre got acceptable validity results. The PMD was not valid according to the results obtained in this work. The BM achieved a good validity result for the diagnosis of LLD.
High incidence of FLT3 mutations in follicular thyroid cancer: potential therapeutic target in patients with advanced disease stage
Authors: Borowczyk Martyna , Szczepanek-Parulska Ewelina , Dębicki Szymon , Budny Bartłomiej , Janicka-Jedyńska Małgorzata , Gil Lidia , Verburg Frederik A. , Filipowicz Dorota , Wrotkowska Elżbieta , Majchrzycka Blanka , Marszałek Andrzej , Ziemnicka Katarzyna , Ruchała Marek 
Published: March 2020

Background: Conventional treatments for follicular thyroid cancer (FTC) can be ineffective, leading to poor prognosis. The aim of this study was to identify mutations associated with FTC that would serve as novel molecular markers of the disease and its outcome and could potentially identify new therapeutic targets. Methods: FLT3 mutations were first detected in a 29-year-old White female diagnosed with metastasized, treatment-refractory FTC. Analyses of FLT3 mutational status through next-generation sequencing of formalin-fixed, paraffin-embedded FTC specimens were subsequently performed in 35 randomly selected patients diagnosed with FTC. Results: FLT3 mutations were found in 69% of patients. FLT3 mutation-positive patients were significantly older than those that were FLT3 mutation-negative [median age at diagnosis 54 (36–82) versus 45 (27–58) ( p = 0.023)]. Patients over 60 years were 23 times more likely to be FLT3 mutation-positive ( p = 0.006). However, the number of FLT3 mutations did not correlate with age ( r-Pearson: –0.244, p-value: 0.25). A total of 26 mutations were identified in the FLT3 gene with 2–16 FLT3 mutations in each FLT3 mutation-positive patient (mean: 5.6 mutations/patient). Tyrosine kinase domain (TKD) mutations in the FLT3 gene were detected in 58% of FLT3 mutation-positive patients. All FLT3 mutation-positive patients with a disease stage of pT2N1 or worse harbored at least one mutation in the TKD of FLT3. Conclusions: There is a wide spectrum and high frequency of FLT3 mutations in FTC. The precise role of FLT3 mutations in the genesis of FTC, as well as its potential role as a therapeutic target, requires further investigation.