bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of whole-body vibration training, strength training and health education on physical function and neuromuscular function of individuals with knee osteoarthritis: a randomized clinical trial
Authors: Lai Zhangqi , Lee Seullee , Chen Yiyang , Wang Lin 
Published: April 2020

Abstract
Background Knee osteoarthritis (KOA) is among the most common osteoarthritis diseases that affect adults older than 65 years old. Impaired neuromuscular function contributes to the development and/or progression of KOA. As a new modality in strength training, whole-body vibration (WBV) training is considered in the management of KOA. However, the inconsistent results of previous studies dampened the enthusiasm for the clinical application of WBV. Methods Eligible participants with KOA were randomly allocated to WBV, strength training (ST) and health education (HE) groups. Finally, 57 participants completed the intervention and measurements. The participants in each group were encouraged to perform the WBV training, similar strength training or health education program. These supervised interventions were performed three times per week for 8 weeks. Physical function was assessed with Timed Up and Go (TUG) and 6-min Walk Distance tests. Neuromuscular function was measured with isokinetic muscle strength and proprioception. Results All variables of physical function and neuromuscular function failed to change significantly among three groups (p > 0.05). However, compared with the baseline, the time of TUG (mean difference = 0.88 ± 0.78, 95% CI = 0.50 – 1.26, p < 0.001) and most of the variables related to isokinetic knee muscle strength (peak work of flexor at 90°/s, peak torque of extensor at 180°/s, peak work of extensor at 180°/s, peak torque of flexors at 180°/s, and peak work of flexors at 180°/s, all p < 0.05) improved significantly in WBV group. Conclusion WBV training has been recommended for strength training in elderly people and patients with musculoskeletal diseases. The 8-week WBV training under the protocol of our study was not superior to ST and HE. Hence, more clinical studies are required in the future to develop an optimal training protocol. Trial registration It was registered at Chinese Clinical Trial Registry a priori as a clinical trial (ID: ChiCTR-IOR-16009234). Registered 21 September 2016.
Dietary pattern and its’ association with anemia among infants aged 6-23 months in central-south China.
Authors: Huang Zhi , Zhen Ai-bing 
Published: April 2020

Abstract
Background: Anemia is widely prevalent among children, and this study aim to understand dietary patterns and its’ association with anemia. Methods: A cross-sectional design in two waves were conducted at Mayang in 2015 and in 2018. The diet data was collected by questionnaire, and dietary patterns were designed by using principal component analysis. Hemoglobin (Hb) was measured to assess the status of anemia. The association between the dietary patterns and anemia was assessed using the logistic regression model. Results: Four dietary patterns were identified among infants aged 6-23 months in central-south China. Diversified pattern:mainly tubers, dairy products, bean and bean products; traditional pattern: cereals, water and soup, and other vegetables and fruits; breast milk pattern: mainly breast milk but less powered formulas; and multi-nutrient powders pattern: mainly multi-nutrient powders. The prevalence of anemia among infant reduced from 29.49% in 2015 to 20.26% in 2018. The top quartile (Q4) of diversified pattern and multi-nutrient powders pattern deminished the risk of anemia by 45% (OR = 0.55, 95% CI: 0.30 to 0.99, P = 0.047) and 59% (OR = 0.41,95% CI: 0.22 to 0.78, P = 0.006) compared to the lowest quartile (Q1), while the breast milk pattern had a 3.26-fold greater risk of anemia than the lowest quartile (Q1) (OR = 3.26,95%CI:1.83 to 5.81, P <0.001). Conclusions: Four dietary patterns were identified among infants aged 6-23 months in central-south China. The pattern with a variety of food groups should be strengthened to improve anemia among infants.
Intravitreal Conbercept For Branch Retinal Vein Occlusion induced Macular Edema: One Initial Injection Versus Three Monthly Injections
Authors: Chen Xi , Hu Tianming , Zuo Jing , Wu Hao , Liu Zehao , Zhan Yaxin , Xia Ying , Wang Jing , Wei Wei 
Published: April 2020

Abstract
Objective To compare the efficacy of one initial intravitreal injection of conbercept (IVC) versus three monthly IVCs in patients with macular edema (ME) after branch retinal vein occlusion (BRVO). Both options were followed by a pro re nata (PRN) retreatment regimen.Methods This study retrospectively investigated and followed 49 patients with acute ME secondary to BRVO for over a year. 24 subjects received one initial injection (1+PRN group); while, 25 received three monthly injections (3+PRN group). The functional and anatomic outcomes were assessed during each follow-up.Results The general characteristics of the 49 subjects were as follows: mean [SD] age, 56.12 [12.54] years; 28 [57.1%] female; 30 [61.2%] non-ischemic form. Both groups showed a stable gain in visual acuity (VA) with similar logMAR (mean ± SD) (1+PRN group 0.308±0.431, 3+PRN group 0.345±0.366) during the first 12 months. Additionally, both groups exhibited a significant reduction in central foveal thickness (CFT) with no statistically significant difference between them (1+PRN group 220.5 μm ±219.9 μm , 3+PRN group 230.2 μm ±220 μm ). Both treatment groups had similar improvements in logMAR and anatomic outcomes over time. The stratified analysis showed that patients with the non-ischemic form and those with the ischemic form had similar improvements in VA (0.351±0.387 VS 0.289±0.417, P =0.601) during the 12 months follow-ups. The number of injections was lower in the 1+PRN group (4.0±1.7) than in the 3+PRN group (4.6±1.2) ( P =0.155). No adverse effects or unexpected safety issues were reported in either group.Conclusions Conpercept yielded stronger improvements in VA and CFT among patients with BRVO induced ME，independent of their retinal ischemia status. The results showed that the 3+PRN regimens do not lead to better functional outcomes or lower treatment needs in clinical practice as compared to the 1+PRN regimen.
Raynaud`s Phenomenon and MMP-7 are Clinicoserologic Biomarkers in Patients with Connective Tissue Disease Associated Interstitial Lung Disease.
Authors: Chung Sang Wan , Shin So Youn , Lee Seung Hyeun , Choi Hye Sook , Park Myung Jae , Hong Seung-Jae , Lee Yeon-Ah 
Published: April 2020

Abstract
Background: The aim of this study was to investigate clinicoserologic biomarkers associated with the development, progression, and prognosis of connective tissue diseases associated interstitial lung disease (CTD-ILD). Methods: We conducted a single center, a retrospective study including 70 incident patients diagnosed with CTD-ILD and 70 age-, sex-, and type of CTD-matched patients without ILD. Clinical informations, pulmonary function test, and chest CT findings were reviewed using medical records. To identify serologic biomarkers, serum interferon-r-induced protein 10 (IP-10), interleukin (IL)-6, IL-8, IL-10, and matrix metalloproteinase 7 (MMP-7) in patients with CTD-ILD and CTD without ILD were measured. Results: A total of 140 patients were enrolled. The mean was 63.3 ± 11.2 years, and 102 (72.9%) patients were female. Raynaud`s phenomenon (OR 5.96, 95% CI 2.11–16.86) was proved to be a risk factor for developing ILD in CTD by multivariable logistic regression analysis. To analyze distinctive features according to the onset of ILD, CTD-ILD was stratified into three groups: ILD-preceding, simultaneous, and CTD-preceding. The majority of the ILD-preceding group (75%) had worse baseline pulmonary function requiring treatment (DLCO <65%). Serum levels of MMP-7 were associated with the development of ILD in patients with CTD, and also had a significant correlation with CT extent score in the present study. Conclusion: In this study, Raynaud`s phenomenon, and serum levels of MMP-7 were clinicoserologic biomarkers CTD-ILD. Therefore, clinicoserologic biomarkers associated with ILD should be assessed in patients with CTD to provide proper management.
Influence of the margin of error due to the use of aerial photographs on the interpretation of the shoreline changes: Three cases of study (Atlantic coast of Morocco)
Authors: KHALID Khalid El , Maanan Mehdi , Hakkou Mounir , Zourarah Bendahhou 
Published: April 2020

Abstract
In mesotidal environments, the monitoring of shoreline changes is hampered by the determination of this line on aerial photographs. This paper discusses and evaluates the importance of taking into account the margin of error associated in determining the state of the shoreline.
To demonstrate this effect, three cases were selected and studied using aerial photographs from 1946 and 2016 (70-year period). The sites chosen on the Moroccan Atantic coast are very close to each other but evolve differently. We proved statically that the impact of taking into account the margin of error will not have the same effect on the interpretation of the results.
By taking these errors into consideration, the interpretation of the results becomes more consistent and more suitable for the decision-makers.
Age at First Marriage and Fertility Decline in Dabat Health and Demographic Surveillance System Site, northwest Ethiopia: Decomposition analysis
Authors: Alazbih Nega Mihret , Kaya Assefa Hailemariam , Mengistu Mezgebu Yitayal , Gelaye Kassahun Alemu 
Published: April 2020

Abstract
Background: Fertility declines in Ethiopia have been documented since 1990s. Amhara National Regional State has recorded the most noticeable fertility decline. However, specific factors that explain the incipient course of fertility decline area and their relative contributions were not well investigated.Hence, the purpose of this study was to determine the factors that contributed for fertility decline, and to assess the variations in fertility that can be attributed to both changes in characteristics and reproductive behaviors of women aged 15–49 years. Methods: Cross sectional censuses were carried out in Dabat Health and Demographic Surveillance System site in 2008 and 2014. Data for 4,775 and 10,807 women with reproductive age in 2008 and 2014 were used for the analysis. Poisson regression model was employed to assess the trends of determinants of fertility, and Multivariate Decomposition technique was applied to evaluate observed changes in fertility. Results: The findings indicated that there was a reduction of an average 641 births per 1,000 women of the reproductive age during the year 2014 compared to the year 2008 in the surveillance site(P-value <0.001; 95% CI: -669.5, -582.4). This overall change in fertility during the study period was attributed to changing characteristics of women (78%)(P-value <0.001; 95%CI: -537.65, -462.32), and their reproductive behavior (22%)(P-value <0.001; 95% CI: -214.56 to -67.368). The drivers of the recent fertility decline during the study period were the shift observed in the age at first marriage, the change in the proportion of currently married women, the shift in women’s birth to later age and the change in women's education. Conclusion: This study indicated that the overall reduction in fertility was attributed to both changing characteristics of women and their reproductive behavior.The major contributors to the changes in fertility were the postponing of women’s first marriage to later age and the change in the proportion of currently married women over the study period. Encouraging women to complete at least secondary education are important to increase the age at first marriage and birth which intern accelerate the current fertility transition.
Global Scientific Output Trend for Akkermansia muciniphila Research: A Bibliometric and Scientometric Analysis
Authors: Dehghanbanadaki Hojat , Aazami Hossein , Raftar Shahrbanoo Keshavarz Azizi , Ashrafian Fatemeh , Ejtahed Hanieh-Sadat , Hashemi Ehsan , Tavassol Zahra Hoseini , Badi Sara Ahmadi , Siadat Seyed Davar 
Published: April 2020

Abstract
Background

Akkermansia muciniphila is an anaerobic bacterium residing in the healthy intestinal tract of host and its quantity has a negative correlation with various host diseases. This study for the first time provides a holistic bibliometric aspect of Akkermansia research in the literature and shows the hot topic terms of these articles in any period of time.

Methods

Scopus database was selected to retrieve documents relevant to Akkermansia in any language up to 2018. The bibliometric profile of Akkermansia articles including subject area, year distribution, citations, institutions, journals, authors, and countries was systematically characterized and the collaboration networks of authors and countries as well as the burst detection algorithm of the words in the titles, abstracts and keywords were visualized.

Results

There is a progressive growing trend in research on Akkermansia from 2004 to 2018 with a total of 668 articles during this period. Out of 518 original articles, there are 301 animal studies (222 studies on mice) and 150 human studies. Also, 65 various diseases were investigated in these studies. The most focused conditions are obesity (71 articles) and type2 diabetes (39 articles). The United States is the leading country on Akkermansia publications (n=184), followed by China (n=156). PLoS ONE is the most dominant journal with 34 Akkermansia publications. In addition, “cancer” is the hot topic of recent Akkermansia research.

Conclusion

Akkermansia research is of progressive interest during the last decade and the studies on this subject move towards its relationship with cancer and its promising effect on health.
A Novel Subband Fractional Delay Algorithm Based on the Filterbank of Cochlear Implant
Authors: Chen Yousheng , Chen Yan 
Published: April 2020

Abstract
Background: In recent years, microphone array method is gradually applied to speech enhancement of cochlear implant, and the delay parameter is the main parameter of microphone array beamforming technology. Due to the size limitation of cochlear implant, the microphone spacing is very small. In algorithm implementation, delay parameter usually corresponds to fractional sampling point. It is necessary to use fractional delay filter to realize the interpolation of integer sampling points. The traditional fractional delay method is to interpolate sampling points in the whole frequency band of speech. However, the speech frequency band itself is very wide, so the error of the present fractional delay method in cochlear is still large. Methods: We propose a fractional delay algorithm based on the filter bank of cochlear implant. The algorithm deduces and calculates the mathematical expression of the fractional delay filter of each subband, and forms a full band fractional delay filter algorithm to minimize the delay error of the whole band. Realization and results: Through the analysis of the system response curve and the calculation of the delay error, it can be seen that the system response corresponding to the fractional delay of each subband in the cochlear filter bank has only a small deviation from the ideal fractional delay filter. Therefore, the error of the fractional delay filter designed in this paper is very small, which can meet the requirements of cochlear implant using microphone array technology for the precision of delay parameters. Discussions: In this paper, the implementation algorithm of subband fractional delay filter is applied to signal acquisition of cochlear implant. Considering the space condition and delay parameters in the actual application scenario, the value of fractional delay can be any continuous real number between 0 and 3, and the error situation of the algorithm can be calculated and analyzed in this range. If the algorithm is extended to other applications, the numerical range of fractional delay can be extended. From the statistics of the average error, it can be seen that the average error of the proposed algorithm in the whole frequency band is extremely small, which can meet the needs of the accuracy of the delay parameters in the application of cochlear implant. Conclusions: The proposed fractional delay filter based on the minimum subband error of cochlear implant can not only realize the local fractional delay minimization, but also the error minimization of the whole frequency band.
Analysis of association between MALAT1 haplotype and the severity of Normal Tension Glaucoma (NTG)
Authors: Yue Jinliang , Zheng Shu-feng 
Published: April 2020

Abstract
Background: The haplotype in MALAT1 affects its expression and is correlated with human diseases like Normal Tension Glaucoma (NTG), although its detailed mechanism remains unclear. Methods: Quantitative real-time PCR was performed to assess the expression of MALAT1, miR-1 and IL-6 in the serum of NTG patients with different haplotypes of MALAT1, as well as in HUVEC and HTMC cells transfected with MALAT1. ELISA was used to analyze the IL-6 level in the serum of NTG patients. RNFL thickness, RA and C/D ratio were calculated for NTG patients. A luciferase assays was carried out to evaluate the inhibitory effect of miR-1 on MALAT1 and IL-6 expression. Western blot was used to analyze the IL-6 protein level in HUVEC and HTMC cells transfected with MALAT1.Results: Accordingly, GGGT haplotype was demonstrated to be associated with a decreased risk of NTG. The MALAT1 level in serum of NTG patients carrying GGGT haplotype was significantly decreased compared with NTG patients carrying other haplotypes, along with elevated miR-1 expression and diminished IL-6 expression. NTG patients carrying GGGT haplotype had thicker RNFL and RA, but a smaller C/D ratio. Sequence analysis found potential target sites of miR-1 on MALAT1 and IL-6, and luciferase assay confirmed the inhibitory effect of miR-1 on MALAT1 and IL-6 expression. Meanwhile, MALAT1 also down-regulated miR-1 expression and consequently up-regulated IL-6 expression. Conclusion: This study presented evidence for a regulatory network containing MALAT1, miR-1 and IL-6, and further demonstrated the effect of MALAT1 haplotype on the risk and severity of NTG.
A novel radio-sensitization method for lung cancer therapy: enhanced radiosensitization induced by antigens/antibodies reaction after targeting tumor hypoxia using Bifidobacterium
Authors: Yang Juan , Wu Zhouxue , Chen Yao , Hu Chuanfei , Li Dong , Liao Yin , Li Yi , Wen Qinglian , Chen Yue , Fu Shaozhi , Wu Jingbo 
Published: April 2020

Abstract
Background：The hypoxic microenvironment of solid tumors reduces the susceptibility of cancer cells to radiotherapy. Current treatments are focused on the development of anti-cancer agents that selectively target tumor cells with no toxicity to healthy tissue. Bacteria colonize and destroy tumors and have emerged as biological vectors that can survive in the tumor microenvironment. Methods：In this study, a Lewis lung carcinoma transplant mouse model was established and treated with a combination of bifidobacterium infantis (Bi), its specific monoclonal antibodies (Ab) and radiotherapy (RT). 18F-FDG PET/CT and 18F-FMISO PET/CT imaging were performed to monitor tumor growth and hypoxia in the tumor tissue. Phosphorylated histone (γ-H2AX), the proliferation index (Ki-67), platelet endothelial cell adhesion molecules (CD31), tumor necrosis factor-α (TNF-α), hypoxia inducible factor-1α (HIF-1α) and glucose transporter 1 (Glut-1) levels were assessed through immunohistochemistry. Results：The results showed that the combined treatment group (Ab+ Bi+ RT) displayed delayed tumor growth and prolonged the survival of mice. The combined treatment group also had lower levels of HIF-1α, Glut-1, and CD31 expression, and a lower uptake of FDG and FMISO. The tumors treated with the combination therapy also had lower levels of hypoxia, and increased γ-H2AX and TNF-α expression. Conclusion：Taken together, these data suggest that the combination of bifidobacterium infantis and its specific monoclonal antibodies can markedly improve the efﬁcacy of radiotherapy for the treatment of lung cancer.
Influence of Tumor Location on Short- and Long-Term Outcomes After Laparoscopic Surgery for Rectal Cancer: A Propensity Score Matched Cohort Study
Authors: Yang Hong , Yao Zhendan , Cui Ming , Xing Jiadi , Zhang Chenghai , Zhang Nan , Liu Maoxing , Xu Kai , Tan Fei , Su Xiangqian 
Published: April 2020

Abstract
Background: This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC). Methods: Patients with rectal cancer undergoing laparoscopic resection with curative intent were retrospectively reviewed between 2009 and 2015. After matched 1:1 by using propensity score analysis, perioperative and oncological outcomes were compared between LRC and M/HRC groups. Multivariate analysis was performed to identify independent factors of overall survival (OS) and disease-free survival (DFS). Results: Of 373 patients who met the criteria for inclusion, 260 patients were matched for the analysis. Laparoscopic surgery for LRC required longer operative time (P＜0.001) and more blood loss volume (P＜0.001) compared with M/HRC, and the LRC group tended to have a higher incidence of postoperative complications (18.5% vs. 10.0%, P=0.051). There was no significant difference in local recurrence between the two groups (6.2% vs. 2.3%, P=0.216), whereas distant metastasis was more frequent in LRC patients compared with M/HRC (19.2% vs. 9.2%, P=0.021). The LRC group showed significantly inferior 5-year OS (78.1% vs. 88.8%, P=0.008) and DFS (76.2% vs. 89.0%, P=0.004) compared with the M/HRC group. Multivariate analysis indicated that tumor location was an independent predictor of OS (HR=2.095, 95% CI 1.142-3.843, P=0.017) and DFS (HR=2.320, 95% CI 1.251-4.303, P=0.008). Conclusion: Tumor location of the rectal cancer significantly affected the clinical and oncological outcomes after laparoscopic surgery, and it was an independent predictor of OS and DFS.
Percutaneous intramedullary screw fixation in lateral malleolar ankle fractures
Authors: Abulsoud Mohamed Ibrahim , Sebaie Adnan Al , Darwish Ahmed , Moawad Mohamed , Elzahed Ehab , El-Ghaffar Tarek M Abd , Elmarghany Mohammed , Elgeushy Ahmed 
Published: April 2020

Abstract

Background: To evaluate the outcome of percutaneous fixation of lateral malleolar ankle fractures by intramedullary screw.Methods: Twenty-five patients with Weber A and Weber B displaced lateral malleolus fractures were retrospectively reviewed after they had done closed reduction and percutaneous internal fixation with an intramedullary fully threaded screw with a washer. A 3.5-mm, fully threaded, self- tapping bone screw. The length of the screw varies between 90 mm and 110 mm, depending on the fracture location and pattern.Results: All fractures united within an average time to union of 5.86 ± 1.74 weeks. There were no deep wound infections or complaints of painful hardware. At the latest follow-up, functional results were excellent in 16 patients (64%) good in 8 patients (32 %), fair in one patient (4%).Conclusion Percutaneous intramedullary screw fixation is a good easy technique in the management of lateral malleolar fracture that provides good clinical and radiological results as it is rapid, minimally invasive and without prominent hardware.