bluuebunny/crossref_metadata_2025_split huggingface dataset:
BMI, high-sensitivity C-reactive protein and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults: a cohort study
Authors: Xu Renying , Shen Peixiao , Wu Chunhua , Wan Yanping , Fan Zhuping , Gao Xiang 
Published: August 2020

AbstractObjective:We performed the cohort study to evaluate the association between BMI, high-sensitivity C-reactive protein (hs-CRP) and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults.Design:Metabolically healthy was defined as participants without history of metabolic diseases and with normal fasting blood glucose level, glycated Hb A1c level, blood pressure, lipid profile, serum uric acid level and liver ultrasonographic findings at baseline. Participants were either classified into normal weight (18·5 ≤ BMI < 24·0 kg/m2) and overweight (BMI ≥ 24·0 kg/m2) based on baseline BMI, or low (<1 mg/l) and high (≥1 mg/l) groups based on baseline hs-CRP. The conversion from metabolically healthy to unhealthy phenotype was deemed if any of the metabolic abnormalities had been confirmed twice or more during 5 years of follow-up.Results:Included were 4855 (1942 men and 2913 women, aged 36·0 ± 8·9 years) metabolically healthy Chinese adults. We identified 1692 participants who converted to metabolically unhealthy phenotype during the follow-up. Compared with their counterparts, the adjusted hazards ratio of the conversion was 1·19 (95 % CI 1·07, 1·33) for participants with overweight, while it was 1·15 (95 % CI 1·03, 1·29) for those with high hs-CRP level (≥1 mg/l). Further adjustment of hs-CRP did not materially change the association between BMI and the conversion. However, the association between hs-CRP and the conversion was not significant after further adjustment of BMI. The sensitivity analysis generated similar results to main analysis.Conclusion:BMI was associated with the risk of the conversion from metabolically healthy to unhealthy status in Chinese adults.
Status of palliative care education in Mainland China: A systematic review
Authors: Willemsen Antonia M. , Mason Stephen , Zhang Silja , Elsner Frank 
Published: August 2020

AbstractObjectiveChina is home to one-fifth of the world's population. In the setting of a growing and aging population as well as the designation of palliative care access as a human right in 2013, the implementation of palliative care in China gains special importance. Palliative care education is an important precondition to ensure a nationwide access to palliative care. This systematic review details the status of under- and postgraduate palliative care education in China, examining both the students’ and physicians’ perception, knowledge, and skills in palliative care, and the available educational interventions and programs.MethodFour databases were searched in September 2018, using considered search terms. Titles, abstracts, and, if necessary, full texts were scanned to identify publications matching the inclusion criteria.ResultsNine publications were included. They revealed six findings: palliative care education is lacking in both under- and postgraduate medical education, only a few programs exist. Palliative care as a concept is well known, detailed knowledge, and practical skills are less developed. Chinese physicians consider palliative care an important field to be developed in cancer care, yet the majority of healthcare professionals are not willing to work in palliative care services. Communication should be a main emphasis in palliative care education, especially in undergraduate training. Finally, there is no highly qualified research on under- or postgraduate palliative care education in Mainland China.Significance of resultsThese findings suggest that palliative care education in China is in demand and should be systematically integrated into medical education. Further research on the topic is urgently needed.
International vs. area? The disciplinary-politics of knowledge-exchange between IR and Area Studies
Authors: Aris Stephen 
Published: August 2020

AbstractWithin the political-economy of the social sciences, Area Studies (AS) is supposed to supply contextually-informed knowledge on (non-Western) areas to the other social sciences, in exchange for theory to guide further empirical investigations. Based on this assumption, there are regular calls for greater engagement with AS to counteract the shortcomings of International Relations’ (IR) knowledge-base on many areas, perspectives, and practices of the international. However, there has been little work empirically detailing knowledge-exchange practices between IR and AS, so it remains an open question if the relationship functions as an exchange of ‘international’ theory-for-‘area’ empirics. This paper provides a macro-sociological analysis of the practices of IR–AS knowledge-exchange. By focusing on citation practice, it moves beyond accounts that treat the two disciplines as ‘black boxes’, to trace which parts of the ‘dividing discipline’ of IR are active in exchanging knowledge with which ‘area’ scholarships. Hence, it asks: Are there ‘area’ blindspots in IR's knowledge-production? And, what type of IR theory is exported to AS? This analysis informs an assessment of whether AS represents a significant resource for IR in its efforts to, one, better inform its knowledge-production about ‘other’ areas of the international, and two, assert its disciplinary-relevance within the academy.
The GFDL Global Atmospheric Chemistry‐Climate Model AM4.1: Model Description and Simulation Characteristics
Authors: Horowitz Larry W. , Naik Vaishali , Paulot Fabien , Ginoux Paul A. , Dunne John P. , Mao Jingqiu , Schnell Jordan , Chen Xi , He Jian , John Jasmin G. , Lin Meiyun , Lin Pu , Malyshev Sergey , Paynter David , Shevliakova Elena , Zhao Ming 
Published: August 2020

AbstractWe describe the baseline model configuration and simulation characteristics of the Geophysical Fluid Dynamics Laboratory (GFDL)'s Atmosphere Model version 4.1 (AM4.1), which builds on developments at GFDL over 2013–2018 for coupled carbon‐chemistry‐climate simulation as part of the sixth phase of the Coupled Model Intercomparison Project. In contrast with GFDL's AM4.0 development effort, which focused on physical and aerosol interactions and which is used as the atmospheric component of CM4.0, AM4.1 focuses on comprehensiveness of Earth system interactions. Key features of this model include doubled horizontal resolution of the atmosphere (~200 to ~100 km) with revised dynamics and physics from GFDL's previous‐generation AM3 atmospheric chemistry‐climate model. AM4.1 features improved representation of atmospheric chemical composition, including aerosol and aerosol precursor emissions, key land‐atmosphere interactions, comprehensive land‐atmosphere‐ocean cycling of dust and iron, and interactive ocean‐atmosphere cycling of reactive nitrogen. AM4.1 provides vast improvements in fidelity over AM3, captures most of AM4.0's baseline simulations characteristics, and notably improves on AM4.0 in the representation of aerosols over the Southern Ocean, India, and China—even with its interactive chemistry representation—and in its manifestation of sudden stratospheric warmings in the coldest months. Distributions of reactive nitrogen and sulfur species, carbon monoxide, and ozone are all substantially improved over AM3. Fidelity concerns include degradation of upper atmosphere equatorial winds and of aerosols in some regions.
Storm‐Time Coupling of Equatorial Nighttime F Region Neutral Winds and Plasma Drifts
Authors: Navarro L. A. , Fejer B. G. 
Published: August 2020

AbstractWe used observations from the Peruvian Fabry‐Perot Interferometer network and from the Jicamarca radar to study the coupling of equatorial nighttime thermospheric winds and ionospheric drifts under moderate solar flux conditions. We show that the coupling of the extended quiet time zonal winds and drifts increases from dusk to midnight and is stronger during equinox than during June solstice. After midnight, they are strongly coupled, except during December solstice when the drifts are stronger. The nighttime disturbance zonal winds and drifts, derived by removing the corresponding quiet time values, are westward with peak magnitudes around midnight. They are in close agreement, except at early night when the winds are stronger, and have strongest (weakest) magnitudes during equinox (June solstice). We also present observations showing the strong neutral wind‐plasma drift coupling during the September 2017 and August 2015 large geomagnetic storms. We show that during the early phase of the September 2017 storm there were large and short‐lived, prompt penetration electric field‐driven, correlated oscillations (~1 hr) in the vertical and zonal plasma drifts, and in the zonal and meridional winds. These are the first observations of prompt penetration‐driven equatorial zonal and meridional wind disturbances. In this event, the vertical and zonal drift oscillations were anticorrelated, and the zonal winds followed the zonal drift oscillations with a delay of ~15 min. Our results illustrate the strong coupling of equatorial thermospheric winds and plasma drifts during geomagnetically quiet as well as during short‐lived prompt penetration and long‐lasting disturbance dynamo events.
Australian Rainfall Anomalies in 2018–2019 Linked to Indo‐Pacific Driver Indices Using ERA5 Reanalyses
Authors: Watterson I. G. 
Published: August 2020

AbstractThe 2019 and 2018–2019 periods had record low All‐Australia rainfall in both observations and the ECMWF's Reanalysis 5, or ERA5, data set over 1979–2019. An analysis of the relationships between interannual variability of rainfall and atmospheric circulation, vertically integrated moisture flux, and temperature anomalies using ERA5 alone is undertaken. Both standard driver indices and those that combine the Pacific and Indian Ocean influences are used. Regression fields for low annual Australian rainfall show a widespread negative rainfall anomaly extending into the east Indian Ocean or IND region and a positive anomaly in the western Pacific PAC region. A moisture flux anomaly takes moisture eastwards toward PAC. This pattern largely persists in the four seasons. In March–May 2019 it can be partially linked to a positive Niño 3.4 anomaly and in June–August to a positive Indian Ocean Dipole. For the annual case, the detrended Niño 4 index explains 24% of the 2019 ERA5 Australian rainfall deficit. This rises to 38% for the 2018–2019 deficit (46% for observations), for the Pacific‐Indian Dipole index that combines the PAC and IND regions, whose sea surface temperature anomalies have opposite effects. The correlation of the index with 2‐year rainfall is −0.7. There is much variability, in the Australian monsoon rainfall especially, that is not linked to simple indices, although rainfall is well matched with moisture flux convergence. This extends to the equatorial zone where the climate of the Maritime Continent can be better examined with ERA5's 0.25° data.
New Insights Into Legacy Phosphorus From Fractionation of Streambed Sediment
Authors: Lannergård Emma E. , Agstam‐Norlin Oskar , Huser Brian J. , Sandström Sara , Rakovic Jelena , Futter Martyn N. 
Published: August 2020

AbstractStreambed and lake sediment was studied in Sävjaån, a eutrophic mesoscale catchment (722 km2) in central Sweden. Triplicate sediment cores from five lakes and nine streams, ranging from headwater to fourth order, were sampled. The sediment was analyzed with a sequential extraction method, where six different phosphorus (P) fractions were measured. The results showed that streambed sediments store considerable amounts of P and in some cases have comparable P contents (g/kg DW) to lake sediment. Land use, soil type, and drainage area (location in the catchment) had a significant effect on the different P fractions found in surficial sediments. Sediment from lakes and forested headwater streams generally had high proportions of organic P and iron bound P. In larger streams located in agricultural areas on clay soils closer to the catchment outlet, with dense sediment and a relatively low proportion of organic matter, P was to a larger extent bound to calcium. Streambed sediment may be an important catchment scale P store and should be considered when modeling catchment P dynamics. The large stores of streambed legacy P should also be considered when performing ditch maintenance to avoid unnecessary mobilization of bioavailable P.
Characterization of FLT3-ITDmut acute myeloid leukemia: molecular profiling of leukemic precursor cells
Authors: Travaglini Serena , Angelini Daniela Francesca , Alfonso Valentina , Guerrera Gisella , Lavorgna Serena , Divona Mariadomenica , Nardozza Anna Maria , Consalvo Maria Irno , Fabiani Emiliano , De Bardi Marco , Neri Benedetta , Forghieri Fabio , Marchesi Francesco , Paterno Giovangiacinto , Cerretti Raffaella , Barragan Eva , Fiori Valentina , Dominici Sabrina , Del Principe Maria Ilaria , Venditti Adriano , Battistini Luca , Arcese William , Lo-Coco Francesco , Voso Maria Teresa , Ottone Tiziana 
Published: August 2020

AbstractAcute myeloid leukemia (AML) with FLT3-ITD mutations (FLT3-ITDmut) remains a therapeutic challenge, with a still high relapse rate, despite targeted treatment with tyrosine kinase inhibitors. In this disease, the CD34/CD123/CD25/CD99+ leukemic precursor cells (LPCs) phenotype predicts for FLT3-ITD-positivity. The aim of this study was to characterize the distribution of FLT3-ITD mutation in different progenitor cell subsets to shed light on the subclonal architecture of FLT3-ITDmut AML. Using high-speed cell sorting, we sequentially purified LPCs and CD34+ progenitors in samples from patients with FLT3-ITDmut AML (n = 12). A higher FLT3-ITDmut load was observed within CD34/CD123/CD25/CD99+ LPCs, as compared to CD34+ progenitors (CD123+/−,CD25−,CD99low/−) (p = 0.0005) and mononuclear cells (MNCs) (p < 0.0001). This was associated with significantly increased CD99 mean fluorescence intensity in LPCs. Significantly higher FLT3-ITDmut burden was also observed in LPCs of AML patients with a small FLT3-ITDmut clones at diagnosis. On the contrary, the mutation burden of other myeloid genes was similar in MNCs, highly purified LPCs and/or CD34+ progenitors. Treatment with an anti-CD99 mAb was cytotoxic on LPCs in two patients, whereas there was no effect on CD34+ cells from healthy donors. Our study shows that FLT3-ITD mutations occur early in LPCs, which represent the leukemic reservoir. CD99 may represent a new therapeutic target in FLT3-ITDmut AML.
RETRACTED ARTICLE: Origin and cross-species transmission of bat coronaviruses in China
Authors: Latinne Alice , Hu Ben , Olival Kevin J. , Zhu Guangjian , Zhang Libiao , Li Hongying , Chmura Aleksei A. , Field Hume E. , Zambrana-Torrelio Carlos , Epstein Jonathan H. , Li Bei , Zhang Wei , Wang Lin-Fa , Shi Zheng-Li , Daszak Peter 
Published: August 2020

AbstractBats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Bayesian statistical framework and a large sequence data set from bat-CoVs (including 630 novel CoV sequences) in China to study their macroevolution, cross-species transmission and dispersal. We find that host-switching occurs more frequently and across more distantly related host taxa in alpha- than beta-CoVs, and is more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats.
Blood substitution therapy rescues the brain of mice from ischemic damage
Authors: Ren Xuefang , Hu Heng , Farooqi Imran , Simpkins James W. 
Published: August 2020

AbstractAcute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient middle cerebral artery occlusion stroke model, a novel therapeutic strategy is proposed, where blood replacement (BR) robustly reduces infarctions and improves neurological deficits in mice. Our analyses of immune cell subsets suggest that BR therapy substantially decreases neutrophils in blood following a stroke. Electrochemiluminescence detection demonstrates that BR therapy reduces cytokine storm in plasma and ELISA demonstrates reduced levels of matrix metalloproteinase-9 (MMP-9) in the plasma and brains at different time points post-stroke. Further, we have demonstrated that the addition of MMP-9 to the blood diminishes the protective effect of the BR therapy. Our study is the first to show that BR therapy leads to profoundly improved stroke outcomes in mice and that the improved outcomes are mediated via MMP-9. These results offer new insights into the mechanisms of stroke damage.
Ultrafast terahertz magnetometry
Authors: Zhang Wentao , Maldonado Pablo , Jin Zuanming , Seifert Tom S. , Arabski Jacek , Schmerber Guy , Beaurepaire Eric , Bonn Mischa , Kampfrath Tobias , Oppeneer Peter M. , Turchinovich Dmitry 
Published: August 2020

AbstractA material’s magnetic state and its dynamics are of great fundamental research interest and are also at the core of a wide plethora of modern technologies. However, reliable access to magnetization dynamics in materials and devices on the technologically relevant ultrafast timescale, and under realistic device-operation conditions, remains a challenge. Here, we demonstrate a method of ultrafast terahertz (THz) magnetometry, which gives direct access to the (sub-)picosecond magnetization dynamics even in encapsulated materials or devices in a contact-free fashion, in a fully calibrated manner, and under ambient conditions. As a showcase for this powerful method, we measure the ultrafast magnetization dynamics in a laser-excited encapsulated iron film. Our measurements reveal and disentangle distinct contributions originating from (i) incoherent hot-magnon-driven magnetization quenching and (ii) coherent acoustically-driven modulation of the exchange interaction in iron, paving the way to technologies utilizing ultrafast heat-free control of magnetism. High sensitivity and relative ease of experimental arrangement highlight the promise of ultrafast THz magnetometry for both fundamental studies and the technological applications of magnetism.
Exposure to air pollution and scarlet fever resurgence in China: a six-year surveillance study
Authors: Liu Yonghong , Ding Hui , Chang Shu-ting , Lu Ran , Zhong Hui , Zhao Na , Lin Tzu-Hsuan , Bao Yiming , Yap Liwei , Xu Weijia , Wang Minyi , Li Yuan , Qin Shuwen , Zhao Yu , Geng Xingyi , Wang Supen , Chen Enfu , Yu Zhi , Chan Ta-Chien , Liu Shelan 
Published: August 2020

AbstractScarlet fever has resurged in China starting in 2011, and the environment is one of the potential reasons. Nationwide data on 655,039 scarlet fever cases and six air pollutants were retrieved. Exposure risks were evaluated by multivariate distributed lag nonlinear models and a meta-regression model. We show that the average incidence in 2011–2018 was twice that in 2004–2010 [RR = 2.30 (4.40 vs. 1.91), 95% CI: 2.29–2.31; p < 0.001] and generally lower in the summer and winter holiday (p = 0.005). A low to moderate correlation was seen between scarlet fever and monthly NO2 (r = 0.21) and O3 (r = 0.11). A 10 μg/m3 increase of NO2 and O3 was significantly associated with scarlet fever, with a cumulative RR of 1.06 (95% CI: 1.02–1.10) and 1.04 (95% CI: 1.01–1.07), respectively, at a lag of 0 to 15 months. In conclusion, long-term exposure to ambient NO2 and O3 may be associated with an increased risk of scarlet fever incidence, but direct causality is not established.
Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF
Authors: Gong Hongri , Gao Yan , Zhou Xiaoting , Xiao Yu , Wang Weiwei , Tang Yanting , Zhou Shan , Zhang Yuying , Ji Wenxin , Yu Lu , Tian Changlin , Lam Sin Man , Shui Guanghou , Guddat Luke W. , Wong Luet-Lok , Wang Quan , Rao Zihe 
Published: August 2020

AbstractDiheme-containing succinate:menaquinone oxidoreductases (Sdh) are widespread in Gram-positive bacteria but little is known about the catalytic mechanisms they employ for succinate oxidation by menaquinone. Here, we present the 2.8 Å cryo-electron microscopy structure of a Mycobacterium smegmatis Sdh, which forms a trimer. We identified the membrane-anchored SdhF as a subunit of the complex. The 3 kDa SdhF forms a single transmembrane helix and this helix plays a role in blocking the canonically proximal quinone-binding site. We also identified two distal quinone-binding sites with bound quinones. One distal binding site is formed by neighboring subunits of the complex. Our structure further reveals the electron/proton transfer pathway for succinate oxidation by menaquinone. Moreover, this study provides further structural insights into the physiological significance of a trimeric respiratory complex II. The structure of the menaquinone binding site could provide a framework for the development of Sdh-selective anti-mycobacterial drugs.
Confinement in crystal lattice alters entire photocycle pathway of the Photoactive Yellow Protein
Authors: Konold Patrick E. , Arik Enis , Weißenborn Jörn , Arents Jos C. , Hellingwerf Klaas J. , van Stokkum Ivo H. M. , Kennis John T. M. , Groot Marie Louise 
Published: August 2020

AbstractFemtosecond time-resolved crystallography (TRC) on proteins enables resolving the spatial structure of short-lived photocycle intermediates. An open question is whether confinement and lower hydration of the proteins in the crystalline state affect the light-induced structural transformations. Here, we measured the full photocycle dynamics of a signal transduction protein often used as model system in TRC, Photoactive Yellow Protein (PYP), in the crystalline state and compared those to the dynamics in solution, utilizing electronic and vibrational transient absorption measurements from 100 fs over 12 decades in time. We find that the photocycle kinetics and structural dynamics of PYP in the crystalline form deviate from those in solution from the very first steps following photon absorption. This illustrates that ultrafast TRC results cannot be uncritically extrapolated to in vivo function, and that comparative spectroscopic experiments on proteins in crystalline and solution states can help identify structural intermediates under native conditions.