bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Applications of Additive Manufacturing in Biosensors and Bioanalytical Devices
Authors: Ruan Xiaofan , Wang Yijia , Cheng Nan , Niu Xiangheng , Chang Yu‐Chung , Li Lei , Du Dan , Lin Yuehe 
Published: June 2020

AbstractThe progress of additive manufacturing (AM), known as 3D‐printing, has initiated a revolution in the new generation of biosensors and bioanalytical devices in recent years. The advancement in the resolution of AM has enabled the microfabrication of the architectures of electrodes and sensing layers for high‐performance sensing. Diversiform printable materials, including biocompatible materials, polymers, various gels and metals, have enormously broadened the horizon in sensors and analytical devices for both research and commercial purposes. The considerable shortening of time and cost in sensor prototyping and fabrication has been reported and various highly customizable biosensing platforms and devices are under development. Herein, the most recent studies on the applications of AM in biosensors and bioanalytical devices are summarized with the aim to provide a panorama of emerging 3D‐printing strategies for sensor design and bioanalytical device fabrication.
One‐Step Fabrication of Nanocrystalline Nanonetwork SnO2 Gas Sensors by Integrated Multilaser Processing
Authors: Lei Jincheng , Zhang Qi , Zhao Zeyu , Chen Yizheng , Gao Jennifer , Tong Jianhua , Peng Fei , Xiao Hai 
Published: June 2020

AbstractAn integrated multilaser process is developed to fabricate nanocrystalline nanonetwork SnO2 gas sensors in one integrated procedure, which combines electrodes fabrication, nanomaterials deposition, and postannealing. Interdigit electrodes are fabricated on an Au‐coated fused silica substrate using a picosecond (ps) laser, which ablates the Au coating from the back of the substrate to pattern the electrodes. A novel transmitted Ps laser deposition (TPLD) process is designed to deposit SnO2 nanonetwork on the interdigit electrodes with precise deposition area control under a close target‐to‐substrate distance. The obtained SnO2 nanonetwork is in situ postannealed by a CO2 laser to improve the crystallinity, while the nano morphology and grain size keep intact. To investigate the morphology and formation process of the nanonetwork, the microstructure of the laser‐deposited SnO2 layer is characterized. The crystallization control of CO2 laser annealing is investigated through analyzing the Raman spectrum, X‐ray diffraction (XRD) patterns, and lattice structures of the samples. By exposed to H2 atmosphere, the fabricated gas sensor is demonstrated for H2 monitoring.
Chiral Dinuclear Benzyliminobinaphthoxy‐Palladium Catalyst for Asymmetric Mannich Reaction of Aldimines and Isatin‐Derived Ketimines with Alkylmalononitriles
Authors: Nakamura Ayu , Kuwano Satoru , Sun Junchuan , Araseki Kensuke , Ogino Eri , Arai Takayoshi 
Published: June 2020

AbstractA newly developed dinuclear bis(benzylimino)binaphthol (BIB)−Pd complex showed good catalytic activity for the Mannich reaction of aldimines and isatin‐derived ketimines with alkylmalononitriles to give the products in a highly enantioselective manner.magnified image
Catalyst‐Free Preparation of Perfluoroalkyl‐Phosphoryl Substituted Furans from 1‐Perfluoroalkyl 1,3‐Diketones in Two Steps
Authors: Lozovskiy Stanislav V. , Vasilyev Aleksander V. 
Published: June 2020

AbstractA two‐step catalyst‐free procedure for the construction of 3‐perfluoroalkyl‐2‐(phosphoryl)methyl furans from commercially available 1‐perfluoroalkyl 1,3‐diketones is reported. Propargylic alcohols, prepared by direct alkynylation of the diketones, react with PCl3 via [2,3]‐sigmatropic rearrangement – enolate cyclization sequence, leading to multifunctional furans. The reaction mechanism is supported by DFT study. In addition, the bioactivity modifying effect of phosphoryl group on 3‐perfluoroalkyl furans is depicted.magnified image
Electron Transfer Photoredox Catalysis: Development of a Photoactivated Reductive Desulfonylation of an Aza‐Heteroaromatic Ring
Authors: Qiang‐Liu  , Liu Yu‐Xiu , Song Hong‐Jian , Wang Qing‐Min 
Published: June 2020

AbstractHerein, we report a protocol for desulfonylation of aza‐heteroaromatic rings via photoinduced electron transfer and hydrogen atom transfer. This general protocol has a wide substrate range and moderate to good yields. The utility of the method was demonstrated by the chemoselective desulfonylation of a molecule containing both an aliphatic and an aromatic sulfonamide.magnified image
Preparation of Oxindoles via Visible‐Light‐Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines
Authors: Wang Yu‐Zhao , Lin Wu‐Jie , Zou Jian‐Yu , Yu Wei , Liu Xue‐Yuan 
Published: June 2020

AbstractThe cascade amination/cyclization of N‐arylacrylamides with alkyl amines under visible‐light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two‐step sequence which involves N‐chlorination of alkyl amines and subsequent reductive N−Cl cleavage. This method provides a convenient access to aminated oxindoles.magnified image
Heme Oxygenase 1‐Targeted Hybrid Nanoparticle for Chemo‐ and Immuno‐Combination Therapy in Acute Myelogenous Leukemia
Authors: Yong Seok‐Beom , Kim Jaehyun , Chung Jee Young , Ra Sehee , kim Seong Su , Kim Yong‐Hee 
Published: June 2020

AbstractAcute myelogenous leukemia (AML) is a fatal blood cancer with high patient mortality. Daunorubicin and cytarabine are first‐line chemotherapy for AML, with bone marrow transplantation in most cases. Recently, cancer immunotherapy has been challenged in AML and leukemia‐niche myeloid cells are promising targets for the AML immunotherapy. Heme oxygenase 1 (HO1) is an antioxidative and cytoprotective enzyme inducing chemo‐resistant AML and has been focused as an immune checkpoint molecule in tumor microenvironments. Herein, lipid‐polymer hybrid nanoparticle (hNP) is loaded with tin mesoporphyrin (SnMP), a HO1‐inhibitor, and non‐covalently modified with an engineered antibody for leukemic cell‐targeted delivery. HO1‐inhibiting T‐hNP (T‐hNP/SnMP) enhances chemo‐sensitivity in human leukemia cells. In a human AML‐bearing orthotopic mouse model, intravenously injected T‐hNP not only actively targets to human leukemia cells but passively targets to CD11b+ myeloid cells in a bone marrow niche. The T‐hNP/SnMP enhances the chemo‐therapeutic effect of daunorubicin and boosts immune response by reprogramming bone marrow myeloid cells resulting from the recruitment of the monocyte‐lineage and induction of inflammatory genes. The ex vivo study demonstrates an enhanced immune response of HO1‐inhibited bone marrow CD11b+ myeloid cells against apoptotic leukemia cells. Collectively, HO1‐inhibiting dual cell‐targeted T‐hNP/SnMP has a strong potential as a novel therapeutic in AML.
Hierarchically Structured Porous Piezoelectric Polymer Nanofibers for Energy Harvesting
Authors: Abolhasani Mohammad Mahdi , Naebe Minoo , Hassanpour Amiri Morteza , Shirvanimoghaddam Kamyar , Anwar Saleem , Michels Jasper J. , Asadi Kamal 
Published: June 2020

AbstractHierarchically porous piezoelectric polymer nanofibers are prepared through precise control over the thermodynamics and kinetics of liquid–liquid phase separation of nonsolvent (water) in poly(vinylidene fluoride‐trifluoroethylene) (P(VDF‐TrFE)) solution. Hierarchy is achieved by fabricating fibers with pores only on the surface of the fiber, or pores only inside the fiber with a closed surface, or pores that are homogeneously distributed in both the volume and surface of the nanofiber. For the fabrication of hierarchically porous nanofibers, guidelines are formulated. A detailed experimental and simulation study of the influence of different porosities on the electrical output of piezoelectric nanogenerators is presented. It is shown that bulk porosity significantly increases the power output of the comprising nanogenerator, whereas surface porosity deteriorates electrical performance. Finite element method simulations attribute the better performance to increased volumetric strain in bulk porous nanofibers.
Mapping carbon and nitrogen isotopic composition of fingernails to demonstrate a rural–urban nutrition transition in theCenter‐West, Northeast, and Amazon regions of Brazil
Authors: Nardoto Gabriela B. , da Silva Rodrigo J. , Schor Tatiana , Garavello Maria Elisa P. E. , da Silva Marcia Regina F. , Rodrigues Lívia P. F. , Murrieta Rui Sergio S. , Camilo Ellen A. , Reinaldo Emanoella D. F. , de Aquino Fernanda C. , da Silva Estéfano A. , de Camargo Plinio B. , Moreira Marcelo Z. , Mazzi Edmar A. , Duarte‐Neto Paulo José , Martinelli Luiz Antonio 
Published: June 2020

AbstractObjectiveThe main objective of this study is to investigate diet patterns among rural and urban populations of the Center‐West, Northeast, and Amazon regions of Brazil through the carbon and nitrogen isotopic composition of fingernails, recognizing that the extent of market integration is a key driver of food consumption.Materials and methodsIn the Center‐West, Northeast, and Amazon regions of Brazil, fingernails were sampled in clusters encompassing a major city, town, and rural village. A total of 2,133 fingernails were analyzed. Fingernails were clipped by donors using fingernail clippers. In the laboratory, samples were cleaned then weighed in small tin capsules before being isotopically analyzed for carbon and nitrogen.ResultsThe overall meanδ13C andδ15N were −19.7 ± 2.8‰ and 10.6 ± 1.1‰, respectively. In the more remote villages, where access to food markets is more challenging, lowerδ13C prevails, suggesting that Brazilian staple foods (rice, beans, andfarinha) still dominate. In areas with easier access to food markets,δ13C values were higher, suggesting a change to a diet based on C4plants, typical of a Brazilian supermarket diet. The variability among inhabitants in the same location expressed by a significant inverse correlation betweenδ13C andδ15N fingernail values suggested that “market integration” does not affect everyone equally in each community.Discussion and ConclusionThe nutrition transition has not yet reached some remote villages in these regions of Brazil or that the nutrition transition has not yet reached all residents of these remote villages. On the other hand, in several villages there is a considerable adherence to the supermarket diet or that some residents of these villages are already favoring processed food.
Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event‐based model of disease progression
Authors: Firth Nicholas C. , Primativo Silvia , Brotherhood Emilie , Young Alexandra L. , Yong Keir X.X. , Crutch Sebastian J. , Alexander Daniel C. , Oxtoby Neil P. 
Published: June 2020

AbstractIntroductionThis work aims to characterize the sequence in which cognitive deficits appear in two dementia syndromes.MethodsEvent‐based modeling estimated fine‐grained sequences of cognitive decline in clinically‐diagnosed posterior cortical atrophy (PCA) () and typical Alzheimer's disease (tAD) () at the UCL Dementia Research Centre. Our neuropsychological battery assessed memory, vision, arithmetic, and general cognition. We adapted the event‐based model to handle highly non‐Gaussian data such as cognitive test scores where ceiling/floor effects are common.ResultsExperiments revealed differences and similarities in the fine‐grained ordering of cognitive decline in PCA (vision first) and tAD (memory first). Simulation experiments reveal that our new model equals or exceeds performance of the classic event‐based model, especially for highly non‐Gaussian data.DiscussionOur model recovered realistic, phenotypical progression signatures that may be applied in dementia clinical trials for enrichment, and as a data‐driven composite cognitive end‐point.
Initial joint bleed volume in a delayed on‐demand treatment setup correlates with subsequent synovial changes in hemophilic mice
Authors: Vøls Kåre Kryger , Kjelgaard‐Hansen Mads , Ley Carsten Dan , Hansen Axel Kornerup , Petersen Maj 
Published: June 2020

AbstractBackgroundHemophilic arthropathy is a debilitating morbidity of hemophilia caused by recurrent joint bleeds. We investigated if the joint bleed volume, before initiation of treatment, was linked to the subsequent degree of histopathological changes and the development of bone pathology in a mouse model of hemophilic arthropathy.MethodsFVIII knock‐out (F8‐KO) mice were dosed with a micro‐CT blood pool agent prior to induction of hemarthrosis. Eight hours after induction, the bleed volume was quantified with micro computed tomography (micro‐CT) and recombinant FVIII treatment initiated. On Day 8, inflammation in the knees was characterized by fluorescence molecular tomography. On Day 14, knee pathology was characterized by micro‐CT and histopathology. In a second study, contrast agent was injected into the knee of wild‐type (WT) mice, followed by histopathological evaluation on Day 14.ResultsThe average joint bleed volume before treatment was 3.9 mm3. The inflammation‐related fluorescent intensities in the injured knees were significantly increased on Day 8. The injured knees had significantly increased synovitis scores, vessel counts, and areas of hemosiderin compared to un‐injured knees. However, no cartilage‐ or bone pathology was observed. The bleed volume before initiation of treatment correlated with the degree of synovitis and was associated with high fluorescent intensity on Day 8. In F8‐KO and WT mice, persistence of contrast agent in the joint elicited morphological changes.ConclusionWhen applying a delayed on‐demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on Day 14 reflected the bleed volume prior to initiation of treatment.
Diagnosis and prediction of prognosis for Bickerstaff’s brainstem encephalitis using auditory brainstem response: a case report
Authors: Kurihara Toru , Igarashi Yutaka , Kobai Kaori , Mizobuchi Taiki , Ishii Hiromoto , Matsumoto Noriko , Yokobori Shoji , Yokota Hiroyuki 
Published: June 2020

BackgroundIt is difficult to diagnose Bickerstaff’s brainstem encephalitis (BBE) in the acute phase, and emergency physicians could diagnose BBE as an unknown cause of consciousness disturbance.Case presentationA 75‐year‐old woman presented with dizziness and weakness in both arms 1 week after an upper respiratory infection. She experienced gradual worsening of consciousness, had dilated pupils and no light reflex. She was suspected of brainstem dysfunction at the upper part of the brainstem; however, there were not significant findings on magnetic resonance imaging, cerebrospinal fluid, or electroencephalography. The auditory brainstem response demonstrated a low voltage, but there was no prolonged latency. At a later date, she was diagnosed with BBE based on serum immunoglobulin G anti‐GQ1b antibody. She was discharged home without any neurological sequelae.ConclusionIt is necessary to analyze serum immunoglobulin G anti‐GQ1b antibodies to diagnose BBE. Auditory brainstem response would be helpful in detecting lesions and predicting functional recovery.
Facile Fabrication of Cu‐doped Carbon Aerogels as Catalysts for the Thermal Decomposition of Ammonium Perchlorate
Authors: Zhou Qian , Jin Bo , Chen Junjie , Xiao Yiyi , Chu Shijin , Peng Rufang 
Published: June 2020

AbstractWe report a simple and effective method to produce copper‐doped carbon aerogel (Cu‐CA) using sodium alginate as a carbon precursor through ion crosslinking and high‐temperature carbonization. Results indicate that Cu‐alginate has a 3D scaffold structure with pores. The effect of using different metal salt mass ratios of Cu‐CA on the catalytic thermal decomposition of AP is also investigated. The thermal decomposition temperature of AP decreases by 94.24 °C, and the activation energy of the decomposition reaction is reduced by 45.7 kJ/mol. These results demonstrate that the composite exhibits superior catalytic performance compared with a single‐component transition metal salt.
Scaling up the Bioconversion of Cheese Whey Permeate into Fungal Oil by Mucor circinelloides
Authors: Chan Lauryn G. , Dias Fernanda F. G. , Saarni Andrew , Cohen Joshua , Block David , Taha Ameer Y. , de Moura Bell Juliana M. L. N. 
Published: June 2020

AbstractThe bioconversion of hydrolyzed whey permeate into an oil‐rich biomass by Mucor circinelloides was scaled up from 250 mL to 4 L with the use of an aerated stirred tank bioreactor. Biomass production and oil accumulation were strongly influenced by agitation speed (99–451 rpm) and aeration rate (0.29–1.70 vvm). Higher agitation and aeration rates (e.g., >400 rpm, >1 vvm), resulted in significantly higher biomass yield due to increased oxygen transfer capabilities and better mixing. Additionally, oil accumulation in the fungal biomass was related to high agitation (>400 rpm), while aeration (0.5–1.5 vvm) had no significant effect within the range evaluated. The predictive model was validated at the optimal conditions of 450 rpm and 1 vvm. Maximum biomass yield of 10.7 g L−1 and lipid content of 32% dry biomass were achieved during 120 hours of fermentation. Simultaneous optimization of agitation and aeration in a bioreactor was found to not only improve fungal growth but also lipid content (24% vs. 32%), lipid yield (2.2 vs. 3.1 g L−1) and γ‐linoleic production (73–464 mg L−1) compared to that of shake‐flask. This study resulted in a scaled‐up and optimized fermentation process that increased production of M. circinelloides biomass for subsequent use as raw material for food, feed, and fuel applications. This signifies a starting point for further studies aimed at assessing the development of a fully functioning fungi‐to‐food/fuel system on an industrial scale for several agricultural streams.
Effect of degree of deprotonation of maleic anhydride‐allyl polyethoxy carboxylic acid copolymer on calcium scale
Authors: Wang Liang‐Chen , Zhao Wei‐Dong , Che Yao , Gou Rui‐Kun , Liu Hong‐Bin , Zhu Chen‐Guo , Wang Liang‐Bi , Guan Zhi 
Published: June 2020

AbstractA hydrophilic copolymer (MA‐APEA) containing carboxylic acid group and ethylene oxide group is synthesized from maleic anhydride (MA) and allyloxy polyethoxy carboxylic acid (APEA) in free radical polymerization and its structure is characterized using FT‐IR,1H nuclear magnetic resonance spectrometer and gel permeation chromatographic techniques. Seven polymer solutions with different degrees of deprotonation are prepared by adding caustic solution to the polymer solution. Effects of the degree of deprotonation of the polymer on curbing calcium scale and the corrosion inhibition of low carbon steel are studied. Influences of the operating conditions on inhibition against CaCO3scale by the polymer with different degrees of deprotonation are also investigated. Effects of the degree of deprotonation on CaCO3deposits/precipitate are analyzed using scanning electronic microscope and X‐ray diffraction. The results show that different degrees of deprotonation of the polymer have different influences on different calcium scale and corrosion inhibition of low carbon steel. The performance of the polymer to withstand high alkalinity and high hardness and high temperature decreases with increase in the degree of deprotonation. The change in the degree of deprotonation influences the conversion of aragonite and vaterite to calcite, and hardly impacts the crystal morphology of CaCO3crystals. MA‐APEA has proven to be an excellent calcium scale inhibitor.
Biowaste Orange Peel‐Derived Mesoporous Carbon as a Cost‐Effective Anode Material with Ultra‐Stable Cyclability for Potassium‐Ion Batteries
Authors: Verma Rakesh , Singhbabu Yashabanta N. , Didwal Pravin N. , Nguyen An‐Giang , Kim Jaekook , Park Chan‐Jin 
Published: June 2020

AbstractPotassium‐ion batteries (PIBs) are promising alternative to Lithium‐ion batteries (LIBs) owing to their economic merits. However, the PIBs have not met suitable anode materials comparable to graphite in LIBs. We synthesised an orange peel‐derived mesoporous carbon (OPDMC) as a potential anode material for high performance PIBs via facile one‐step carbonisation with self‐activation from waste orange peel. The OPDMC‐1000, which were carbonised at 1000 °C, exhibited impressive initial discharge/charge capacities of 408/224 mAh g−1 at 30 mA g−1 and retained the reversible capacity of 208.57 mAh g−1 over 100 cycles. Even after 2000 and 3000 cycles at specific currents of 200 and 500 mA g−1, it maintained the reversible capacities of 150.37 and 112 mAh g−1, respectively. A full cell employing the OPDMC exhibited an initial reversible discharge capacity of 185.32 mAh g−1 at 50 mA g−1 with capacity retention of 71.60 % after 50 cycles, indicating its practical applicability.
New near‐infrared emissions and energy transfer in Er3+‐doped MgAl layered double hydroxides
Authors: Chen Yufeng , Zhang Yajiao , Zhang Jiwan , Wang Li 
Published: June 2020

AbstractA series of Er3+‐doped magnesium aluminium layered double hydroxides (Er3+‐doped, MgAl‐LDHs) with different Mg2+/(Al3++Er3+) molar ratios were synthesized using the hydrothermal method. Compositional and structural analyses suggest that the Er3+‐doped MgAl‐LDHs kept a hexagonal structure while the Mg2+/(Al3++Er3+) molar ratio was at 1.0–4.1. The downconverted emission spectra of the Er3+‐doped MgAl‐LDHs showed a red emission at 650 nm and strong infrared emissions at 720, 780, and 850 nm. These infrared emissions were hardly observed in previous downconverted emission spectra of Er3+‐doped materials. In the analysis of the Er3+ energy levels and in relevant published literature, the energy transfer diagram for Er3+‐doped in MgAl‐LDHs is described, and infrared emissions at 720, 780, and 850 nm may be attributed to 4F7/2→4I13/2, 2H11/2→4I13/2, and 4S3/2→4I13/2 transitions of Er3+, respectively. Er3+‐doped MgAl‐LDHs could have potential application as marking and targeting agents in the processes for drug delivery in consideration of the strong near‐infrared Er3+emissions, as well as the special layered structure of MgAl‐LDH.
Lenalidomide plus rituximab Vs rituximab alone in relapsed or refractory indolent lymphoma: A cost‐effectiveness analysis
Authors: Zhang Peng‐Fei , Xie Dan , Wen Feng , Li Qiu 
Published: June 2020

AbstractBackgroundThe aim of the study was to evaluate the cost‐effectiveness of lenalidomide plus rituximab vs rituximab alone in patients with relapsed or refractory indolent lymphoma.MethodsA Markov decision model was established to carry out the cost‐effectiveness analysis. Three discrete health states, progression‐free survival (PFS), progressive disease (PD), and death, were included. Cycle length was set at 1 month, and utility scores were derived from previously published literature. The incremental cost‐effectiveness ratio (ICER) was defined as the primary endpoint, and the willingness‐to‐pay (WTP) threshold was set at $29,306.43 per quality‐adjusted life year (QALY). Both cost and effectiveness were determined using a 3% annual discount rate. Furthermore, one‐way and probabilistic sensitivity analyses were performed to check the robustness of the model.ResultsLenalidomide plus rituximab gained 6.08 QALYs at a cost of $120,979.62 while rituximab alone gained 4.84 QALYs at a cost of $48,052.11. The ICER of lenalidomide plus rituximab vs rituximab alone was $58,812.51/QALY. The parameters most significantly influenced the model were the utility values for the PFS state, the duration of the PFS state in the lenalidomide plus rituximab group, and the cost of lenalidomide. The probability of lenalidomide plus rituximab or rituximab alone being the most cost‐effective option was 0% and 100%, respectively, at a WTP threshold of $29,306.43/QALY.ConclusionsLenalidomide plus rituximab is not a cost‐effective strategy compared with rituximab monotherapy for relapsed or refractory indolent lymphoma from a Chinese societal perspective.