bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Pharmaco-Mechanical Thrombectomy of Acute Symptomatic Superior Mesenteric Vein Thrombosis
Authors: Rabuffi Paolo , Vagnarelli Simone , Bruni Antonio , Antonuccio Gabriele , Ambrogi Cesare 
Published: October 2019

Abstract

Purpose
To evaluate the safety and the efficacy of percutaneous pharmaco-mechanical thrombectomy (PPMT) of acute superior mesenteric vein (SMV) thrombosis.

Methods
A database of patients treated between 2011 and 2018 with acute venous mesenteric ischemia (VMI) was reviewed. VMI was diagnosed in the presence of SMV thrombosis and CT evidence of jejunal thickening. All patients presented with mild to moderate peritonism, which allowed surgery to be postponed. Initial treatment consisted of heparinization. PPMT was indicated in case of worsening abdominal pain despite anticoagulation and was performed via a transjugular or transhepatic approach, using a rotational aspiration thrombectomy catheter, followed by transcatheter thrombolysis. Clinical success was defined as symptoms resolution. Technical success was defined as patency of > 50% of SMV at venography and resolution of jejunal thickening. Patients were discharged on lifelong oral anticoagulation (INR 2.5–3.5). Follow-ups were performed using CT and color Doppler ultrasound.

Results
Population consisted of eight males, aged 37–81 (mean 56.5 years). Causes for thrombosis were investigated. Urokinase infusion time ranged from 48 to 72 h (3,840,000–5,760,000 IU). Clinical and technical success was obtained in all cases. One patient experienced bleeding from the superior epigastric artery and was treated with embolization. One patient died of multi-organ failure after 35 days, despite resolution of SMV thrombosis. In no case was surgery required after PPMT; mean hospitalization was 14.1 days (9–24). Mean follow-up of remaining seven patients was 37.7 months (12–84 months).

Conclusion
PPMT of acute SMV thrombosis seems safe and effective, with an 87.5% long-term survival rate and a 12.5% major complication rate.
The evaluation of a slim perimodiolar electrode: surgical technique in relation to intracochlear position and cochlear implant outcomes
Authors: Heutink Floris , Verbist Berit M. , Mens Lucas H. M. , Huinck Wendy J. , Mylanus Emmanuel A. M. 
Published: October 2019

Abstract

Purpose
In cochlear implantation (CI), the two factors that are determined by the surgeon with a potential significant impact on the position of the electrode within the cochlea and the potential outcome, are the surgical technique and electrode type. The objective of this prospective study was to evaluate the position of the slim, perimodiolar electrode (SPE), and to study the influence of the SPE position on CI outcome.

Methods
Twenty-three consecutively implanted, adult SPE candidates were included in this prospective cohort study conducted between December 2016 and April 2019. Mean age at surgery was 59.5 years. Mean preoperative residual hearing was 92.2 dB. Intra-operative fluoroscopy and high-resolution computed tomography scans were performed to evaluate electrode position after insertion using a cochleostomy (CS) approach. Follow-up was 12 months after implantation; residual hearing (6–8 weeks) and speech perception (6–8 weeks and 12 months) were evaluated in relation to the intracochlear SPE position.

Results
In most patients in whom the SPE was positioned in the scala tympani residual hearing was preserved [mean absolute increase in PTA of 4.4 dB and 77.2% relative hearing preservation (RHP%)]. Translocation into the scala vestibuli occurred in 36% of the insertions, resulting in a mean absolute increase in PTA of 17.9 dB, and a RHP% of 19.2%. Participants with a translocation had poorer speech perception scores at 12-month follow-up.

Conclusion
Given the incidence of CS-associated translocations with the SPE and the negative effect on outcome, it is advised to insert the SPE using the (extended) round window approach.
Asymptotic Analysis of Regular Sequences
Authors: Heuberger Clemens , Krenn Daniel 
Published: October 2019

Abstract
In this article, q-regular sequences in the sense of Allouche and Shallit are analysed asymptotically. It is shown that the summatory function of a regular sequence can asymptotically be decomposed as a finite sum of periodic fluctuations multiplied by a scaling factor. Each of these terms corresponds to an eigenvalue of the sum of matrices of a linear representation of the sequence; only the eigenvalues of absolute value larger than the joint spectral radius of the matrices contribute terms which grow faster than the error term. The paper has a particular focus on the Fourier coefficients of the periodic fluctuations: they are expressed as residues of the corresponding Dirichlet generating function. This makes it possible to compute them in an efficient way. The asymptotic analysis deals with Mellin–Perron summations and uses two arguments to overcome convergence issues, namely Hölder regularity of the fluctuations together with a pseudo-Tauberian argument. Apart from the very general result, three examples are discussed in more detail:sequences defined as the sum of outputs written by a transducer when reading a q-ary expansion of the input;the amount of esthetic numbers in the first N natural numbers; andthe number of odd entries in the rows of Pascal’s rhombus. For these examples, very precise asymptotic formulæ are presented. In the latter two examples, prior to this analysis only rough estimates were known.
Dividing Splittable Goods Evenly and With Limited Fragmentation
Authors: Damaschke Peter 
Published: October 2019

AbstractA splittable good provided innpieces shall be divided as evenly as possible amongmagents, where every agent can take shares from at mostFpieces. We callFthe fragmentation and mainly restrict attention to the cases$$F=1$$F=1and$$F=2$$F=2. For$$F=1$$F=1, the max–min and min–max problems are solvable in linear time. The case$$F=2$$F=2has neat formulations and structural characterizations in terms of weighted graphs. First we focus on perfectly balanced solutions. While the problem is strongly NP-hard in general, it can be solved in linear time if$$m\ge n-1$$m≥n-1, and a solution always exists in this case, in contrast to$$F=1$$F=1. Moreover, the problem is fixed-parameter tractable in the parameter$$2m-n$$2m-n. (Note that this parameter measures the number of agents above the trivial threshold$$m=n/2$$m=n/2.) The structural results suggest another related problem where unsplittable items shall be assigned to subsets so as to balance the average sizes (rather than the total sizes) in these subsets. We give an approximation-preserving reduction from our original splitting problem with fragmentation$$F=2$$F=2to this averaging problem, and some approximation results in cases whenmis close to eithernorn / 2.
Low seroprotection rate for meningococcus serogroup C in the adult HIV-1-infected population in Austria
Authors: Grabmeier-Pfistershammer Katharina , Holleis Kay , Rosskopf Sandra , Steinberger Peter , Touzeau-Roemer Veronique , Poeppl Wolfgang , Rieger Armin 
Published: October 2019

Summary
Current Advisory Committee on Immunization Practices (ACIP) guidelines recommend immunization of all human immunodeficiency virus (HIV)-infected patients against meningitis serotype ACWY due to recent outbreaks of meningitis C in homosexual men in the USA. Implementation of this recommendation in other countries, such as Austria is hindered by the scarce knowledge on the vaccine coverage. In this study the serostatus for meningococcus serogroup C was analyzed in 390 HIV-infected individuals residing in Austria. These individuals were representative for the Austrian HIV cohort regarding sex, age, transmission risk and HIV progression markers. Overall, 73% were on suppressive antiretroviral therapy, the mean CD4 cell count was 599 cells/μl and immunoglobulin G (IgG) seropositivity was 18% for meningococcus serogroup C. Migrants and patients who had acquired an infection via heterosexual intercourse had a higher chance for meningococcus serogroup C seropositivity. Importantly due to the well-preserved immune status of nearly all participants vaccination would be feasible in the majority of the seronegative patients. It is assumed that this measure would largely reduce the number of patients at risk for this vaccine-preventable disease.
Instantaneously complete Yamabe flow on hyperbolic space
Authors: Schulz Mario B. 
Published: October 2019

Abstract
We prove existence of instantaneously complete Yamabe flows on hyperbolic space of arbitrary dimension $$m\ge 3$$m≥3. The initial metric is assumed to be conformally hyperbolic with conformal factor and scalar curvature bounded from above. We do not require initial completeness or bounds on the Ricci curvature. If the initial data are rotationally symmetric, the solution is proven to be unique in the class of instantaneously complete, rotationally symmetric Yamabe flows.
Spatial learning in Japanese eels (Anguilla japonica)
Authors: Watanabe Shigeru , Shinozuka Kazutaka 
Published: October 2019

Abstract
Japanese eels (Anguilla japonica) were trained on a Morris-type spatial learning task. There were four tubes in a pool, but the eels could hide in only one of these. The eels learned the position of the open tube, and maintained their performance when the pool was rotated to remove possible intra-maze cues. The eels could not maintain their performance in a dark room, suggesting that spatial learning involved extra-maze visual cues. When the position of the open tube was randomly changed every day, the performance of the eels in finding the open tube did not improve.
Ex-neuter-gender nouns in Canadian Doukhobor Russian
Authors: Makarova Veronika 
Published: October 2019

Abstract
This paper addresses the morpho-syntactic forms of ex-neuter-gender of Canadian Doukhobor Russian nouns. Doukhobor Russian is a near-extinct variety of Russian spoken by a small group of elderly Doukhobors (a religious and ethnic minority of Russian origins) residing mostly in British Columbia, Saskatchewan and Alberta. While Standard Russian has three noun genders (feminine, masculine and neuter), this paper demonstrates that in Doukhobor Russian, a neuter gender erosion has been taking place, whereby ex-neuter-gender nouns have been shifting their declension paradigms mostly to feminine F1 declension forms. Ex-neuter-gender words in Doukhobor Russian also mostly agree with pronouns, attributives, and numerals in feminine gender. They also predominantly agree in feminine gender with preterite verb forms. Two major subclasses of ex-neuter-gender nouns are identified: those in which the stem is stressed and those in which the stress is on the inflectional vowel. A stressed vowel in an inflectional suffix of the nominative and the accusative blocks the paradigm shift of ex-neuter-gender nouns, but does not prevent female gender agreement with attributives and preterite verb forms. The discussion identifies parallels of neuter-gender erosion in Doukhobor Russian with similar processes found in 19th and 20th century Russian dialects.
Airborne Staphylococcus aureus in different environments—a review
Authors: Kozajda Anna , Jeżak Karolina , Kapsa Agnieszka 
Published: October 2019

Abstract
The aim of the literature review was to describe the environments where the presence of airborne Staphylococcus aureus was confirmed and to catalogue the most often used methods and conditions of bioaerosol sampling to identify the bacteria. The basis for searching of studies on S. aureus in the bioaerosol in different environments was PubMed database resources from the years 1990–2019 (May). The review included studies which were carried on in selected environments: hospitals and other health care facilities, large-scale animal breeding, wastewater treatment plants, residential areas, educational institutions, and other public places. The highest concentrations and genetic diversity of identified S. aureus strains, including MRSA (methicillin-resistant S. aureus), have been shown in large-scale animal breeding. The role of the airborne transmission in dissemination of infection caused by these pathogens is empirically confirmed in environmental studies. Commonly available, well-described, and relatively inexpensive methods of sampling, identification, and subtyping guarantee a high reliability of results and allow to obtain fast and verifiable outcomes in environmental studies on air transmission routes of S. aureus strains.
Histrionic Personality, Narcissistic Personality, and Problematic Social Media Use: Testing of a New Hypothetical Model
Authors: Savci Mustafa , Turan Mehmet Emin , Griffiths Mark D. , Ercengiz Mustafa 
Published: October 2019

AbstractIn the present study, a hypothetical model examining the relationships between histrionic personality belief, need for social approval, desire for being liked, social media disorder, and narcissistic personality belief was proposed and tested. The effect of histrionic personality belief on the need for social approval and desire for being liked was tested first. Then the effect of the need for social approval and desire for being liked on social media addiction were tested. Finally, the effect of social media addiction on narcissistic personality belief was tested. The present study comprised 305 adolescents (165 girls and 140 boys) and they were administered the Personality Belief Questionnaire-Short Form, Need for Social Approval Scale, Desire for Being Liked Scale, and Social Media Disorder Scale. Before the proposed hypothetical model was tested, each latent variable was tested with measurement models to determine if it could be used in structural models. Findings demonstrated that histrionic personality belief positively affected the need for social approval and desire for being liked. The need for social approval and desire for being liked positively affected social media addiction. Finally, social media addiction positively affected narcissistic personality belief.
Nicht invasive Pränataldiagnostik mittels molekulargenetischer Tests (NIPT) zur Erkennung der Trisomien 13, 18 und 21
Authors: Rummer Anne , Sieben Wiebke , Mosch Christoph , Assall Oliver , Sauerland Stefan 
Published: October 2019

Zusammenfassung

Hintergrund
Molekulargenetische Tests (NIPT) auf Trisomie sind längst Teil der nicht invasiven Pränataldiagnostik (NIPD). In Deutschland wird derzeit geprüft, ob und für wen diese Tests von den gesetzlichen Krankenkassen künftig bezahlt werden sollen.

Fragestellung
(I) Diagnostische Eigenschaften der NIPT zur Entdeckung der Trisomien 13, 18 und 21 und (II) hypothetische Berechnung der möglichen Anwendung der NIPT in verschiedenen Gruppen.

Methoden
(I) Systematische Recherche nach Primärliteratur und systematischen Übersichten in MEDLINE und vier weiteren Datenbanken. Einschlusskriterien: Studien mit schwangeren Frauen, Indextest: NIPT mittels molekulargenetischer Analyse von cffDNA im mütterlichen Blut zur Bestimmung des Trisomie-Risikos; Referenztest: zytogenetische Diagnostik oder postnatale klinische Untersuchung. (II) Orientierende Recherche. Hypothetische Berechnungen für (1) alle schwangeren Frauen nach aktuellem Vorgehen ohne NIPT am Beispiel von Ersttrimesterscreening (ETS), (2) Anwendung bei schwangeren Frauen mit erhöhtem Risiko, z. B. nach vorgeschaltetem auffälligem ETS und (3) NIPT in einer Population mit und ohne erhöhtes Risiko für eine Trisomie.

Ergebnisse
Bei 22 eingeschlossenen Studien lagen die Sensitivität und die Spezifität zur Erkennung der Trisomie 21 bei 99,13 % (95 %-KI: [97,39 %; 99,72 %]) und 99,95 % (95 %-KI: [99,88 %; 99,98 %]). Der mögliche Einfluss von Testversagern blieb bei den Berechnungen unberücksichtigt, womit die Sensitivität oder die Spezifität der NIPT möglicherweise überschätzt wurde. Für die Erkennung der Trisomien 13 und 18 konnte jeweils die Sensitivität nicht robust geschätzt werden.

Diskussion
Bei Frauen mit erhöhtem Risiko können NIPT die Zahl der invasiven Tests und damit der testbedingten Fehlgeburten vermutlich verringern.
Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs
Authors: Korostynski Michal , Morga Rafal , Piechota Marcin , Hoinkis Dzesika , Golda Slawomir , Dziedzic Tomasz , Slowik Agnieszka , Moskala Marek , Pera Joanna 
Published: October 2019

AbstractInfluence of an intracranial aneurysm (IA) rupture on the expression of miRNAs and the potential significance of the resulting changes remains poorly understood. We aimed to characterize the response to the IA rupture through the analysis of miRNAs in peripheral blood cells. Expression of small RNAs was investigated using deep transcriptome sequencing in patients in the acute phase of an IA rupture (first 72 h), in the chronic phase (3–15 months), and controls. A functional analysis and the potential interactions between miRNAs and target genes were investigated. We also measured the levels of proteins that were influenced by regulated miRNAs. We found that 106 mature miRNAs and 90 miRNA precursors were differentially expressed among the groups. The regulated miRNAs were involved in a variety of pathways, and the top pathway involved cytokine-cytokine receptor interactions. The identified miRNAs targeted the inflammatory factorsHMGB1andFASLG. Changes in their expression were detected at the mRNA and protein levels. IA rupture strongly influences the transcription profiles in peripheral blood cells. The regulated miRNAs were involved in the control of immune cell homeostasis. In summary, these results may aid in the elucidation of the molecular mechanisms that orchestrate the inflammatory response to IA rupture.
Prognostic value of the coronary artery calcium score in suspected coronary artery disease: a study of 644 symptomatic patients
Authors: Rijlaarsdam-Hermsen D. , Lo-Kioeng-Shioe M. S. , Kuijpers D. , van Domburg R. T. , Deckers J. W. , van Dijkman P. R. M. 
Published: October 2019

Abstract

Aim
The long-term value of coronary artery calcium (CAC) scanning has not been studied extensively in symptomatic patients, but was evaluated by us in 644 consecutive patients referred for stable chest pain.

Methods
We excluded patients with a history of cardiovascular disease and with a CAC score of zero. CAC scanning was done with a 16-row MDCT scanner. Endpoints were: (a) overall mortality, (b) mortality or non-fatal myocardial infarction and (c) the composite of mortality, myocardial infarction or coronary revascularisation. Revascularisations within 1 year following CAC scanning were not considered.

Results
The mean age of the 320 women and 324 men was 63 years. Follow-up was over 8 years. There were 58 mortalities, while 22 patients suffered non-fatal myocardial infarction and 24 underwent coronary revascularisation, providing 104 combined endpoints. Cumulative 8‑year survival was 95% with CAC score <100, 90% in patients with CAC score >100 and <400, and 82% with CAC score ≥400 Agatston units. Risk of mortality with a CAC score >100 and ≥400 units was 2.6 [95% confidence interval (CI) 1.23–5.54], and 4.6 (95% CI 2.1–9.47) respectively. After correction for clinical risk factors, CAC score remained independently associated with increased risk of cardiac events.

Conclusions
Risk increased with increasing CAC score. Patients with CAC >100 or ≥400 Agatston units were at increased risk of major adverse cardiac events and are eligible for preventive measures. CAC scanning provided incremental prognostic information to guide the choice of diagnostic and therapeutic options in many subjects evaluated for chest pain.
Coronary microvascular function in athletes with abnormal exercise test results
Authors: van de Sande D. A. J. P. , Barneveld P. C. , Hoogsteen J. , Doevendans P. A. , Kemps H. M. C. 
Published: October 2019

Abstract

Aims
In asymptomatic athletes, abnormal exercise test (ET) results have a poor positive predictive value. It is unknown whether abnormal ET results in the absence of obstructive coronary artery disease (CAD) are related to coronary microvascular dysfunction. It is also unknown whether they should be considered false-positive ET results or a consequence of physiological adaptation to sport. In our study, we evaluated whether athletes with abnormal ET results and documented myocardial ischaemia in the absence of obstructive CAD have an attenuated microvascular function and whether coronary microvascular dysfunction is related to endothelial dysfunction.

Methods and results
Nine athletes with concordant abnormal ET and myocardial perfusion scintigraphy (MPS) results without obstructive CAD were compared with age- and gender-matched individuals with a low-to-intermediate a priori risk of CAD. Coronary flow reserve was assessed by Rubidium-82 positron emission tomography (PET) imaging. Endothelin‑1 concentrations were measured to evaluate endothelial function. Coronary flow reserve was significantly lower in athletes (3.3 ± 0.8 versus 4.2 ± 0.6, p = 0.014 respectively). Endothelin‑1 levels were significantly higher in athletes (1.3 ± 0.2 pg/ml versus 1.0 ± 0.2 pg/ml, p = 0.012 respectively). There was no correlation between endothelin‑1 concentrations and mean global coronary flow reserve (r = 0.12).

Conclusion
Athletes with abnormal ET and MPS outcomes indicative for myocardial ischaemia and no obstructive CAD have a lower coronary flow reserve compared with non-athletes with low-to-intermediate a priori risk of CAD, suggesting an attenuated coronary microvascular function. Higher endothelin‑1 concentrations in athletes suggest that endothelial-dependent dysfunction is an important determinant of the attenuated microvascular function.
Estimation of three-dimensional long axes of the maxillary and mandibular first molars with regression analysis
Authors: Terada Kazuto , Kameda Takashi , Kageyama Ikuo , Sakamoto Makoto 
Published: October 2019

Abstract
The purpose of this study was to determine the long axes of molars with multiple roots through ordinary least squares regression (LSR) and to compare them with the axes defined by principal component analysis (PCA). Three-dimensional radiological images of 20 dry skulls were obtained by cone-beam computed tomography (CBCT). Data from maxillary and mandibular first molars were extracted from the CBCT DICOM data with a three-dimensional image visualization system. The obtained data were reconstructed, converted to STL files, and three-dimensional coordinate values were extracted. The long axes were estimated by an algorithm to synchronize the LSR line with the horizontal axis which was translated to the vertical axis. The axes of the molars defined by LSR were compared with the axes of the molars defined by PCA. The coordinate point number of each molar was 5400–5800. The algorithm for determining the tooth axes in this study consisted of four stages containing three steps each. The distance between the two axes calculated by the two methods (LSR and PCA) on the horizontal plane through the origin was less than 10−12 mm and the deviations between them were less than 0.003°. The long axes of the molars estimated by LSR agree almost exactly with the axes estimated by PCA, and the accuracy is sufficient for clinical usage; however, the distance between them would shorten with a more severe convergence condition of the α value at each stage of this LSR system.