bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 and neurocognitive disorders
Authors: Mukaetova-Ladinska Elizabeta B. , Kronenberg Golo , Raha-Chowdhury Ruma 
Published: January 2021

Purpose of review
The COVID-19 infection results in various viral-related physical and mental health problems, joined with the long-term psychological impact of the pandemic in general. However, the accompanying neurocognitive changes remain poorly understood.

Recent findings
We synthetize the current knowledge of viral (SARS-CoV-2) induced inflammation, mechanisms to viral entry into the central nervous system and altered neurotransmitter systems to provide an informed neurobiological explanation for the rise of neurocognitive disorders (defined as per the DSM-5 criteria).

Summary
The mild and major neurocognitive disorder symptoms due to the COVID-19 pandemic provide a unique opportunity to address the early changes underlying neurocognitive impairment at both clinical and molecular level. We discuss the utilization of the available evidence for their management and future novel therapeutic opportunities.
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
Authors: McAlpine Lindsay S. , Fesharaki-Zadeh Arman , Spudich Serena 
Published: January 2021

Purpose of review
Over 70 million people worldwide, including those with neurodegenerative disease (NDD), have been diagnosed with coronavirus disease 2019 (COVID-19) to date. We review outcomes in patients with NDD and COVID-19 and discuss the hypothesis that due to putative commonalities of neuropathogenesis, COVID-19 may unmask or trigger NDD in vulnerable individuals.

Recent findings
Based on a systematic review of published literature, patients with NDD, including dementia, Parkinson's disease, and multiple sclerosis (MS) make up a significant portion of hospitalized COVID-19 patients. Such patients are likely to present with altered mental status or worsening of their preexisting neurological symptoms. Patients with NDD and poor outcomes often have high-risk comorbid conditions, including advanced age, hypertension, diabetes, obesity, and heart/lung disease. Patients with dementia including Alzheimer's disease are at higher risk for hospitalization and death, whereas those with preexisting Parkinson's disease are not. MS patients have good outcomes and disease modifying therapies do not increase the risk for severe disease. Viral infections and attendant neuroinflammation have been associated with the pathogenesis of Alzheimer's disease, Parkinson's disease, and MS, suggesting that COVID-19 may have the potential to incite or accelerate neurodegeneration.

Summary
Since patients with Alzheimer's disease are at higher risk for hospitalization and death in the setting of COVID-19, additional precautions and protective measures should be put in place to prevent infections and optimize management of comorbidities in this vulnerable population. Further studies are needed to determine whether COVID-19 may lead to an increased risk of developing NDD in susceptible individuals.
Study on the characteristics of superconducting electrodynamic suspension system based on dynamic circuit theory
Authors: Hu Daoyu , Zhai Maochun 
Published: December 2020

Purpose
The purpose of this paper is to analyze the influence of different parameters on the characteristics of the superconducting electrodynamic suspension (EDS) system.

Design/methodology/approach
The authors used an analytical model based on the dynamic circuit theory to perform the analysis. The authors proposed an inductance criterion to improve the calculation accuracy. They also proposed a three-dimension finite element method (FEM) to verify the validity of the analytical model.

Findings
The levitation force and guiding force increase with the superconducting magnet (SCM) speed and show a saturated trend, while the drag force decreases with the SCM speed. The vibration characteristic is the inherent characteristic of the superconducting EDS. The frequency and amplitude are affected by the gap between adjacent null-flux coils. The levitation force first increases and subsequently decreases with the levitation height. The total levitation force of the SCM increases with the superconducting coil (SC) number, while the average levitation force of an SC decreases with the SC number. The total levitation force nonlinearly increases with the SC number.

Originality/value
The authors introduced an inductance criterion for better understanding and using the analytical model, and they also proposed a 3D FEM method. The 3D FEM method could be extended to simulate the other EDS systems with more complex structures which the numerical model is no longer applicable. The results of the parameter study could deepen people’s understanding of EDS.
Social imaginaries of violence and fear: the Chilean press and the 1968 global student movement
Authors: Toro-Blanco Pablo 
Published: December 2020

PurposeThis paper aims to explore the construction of social imaginaries of fear by the Chilean press regarding student violence during the 1968 university reforming process. Using an approach inspired by the history of emotions, the primary purpose is to analyze the discourse of two relevant conservative newspapers with national circulation about students' mobilization.Design/methodology/approachThe research rests on the analysis of content in the discourse of the two more representative right-wing Chilean newspapers (El Mercurio and El Diario Ilustrado). Founded in the early years of the 20th century, both had national circulations and were a part of a tradition in the history of the Chilean 20th-century national press. Through the analysis of a selection of editorials and news regarding students' mobilization during 1968, with a focus on the experience of the most prominent institution (Universidad de Chile), this research highlights similarities and differences in the ways that both media endeavoured to elaborate social imaginaries of menace and fear regarding student movements.FindingsThrough the study of the discourse of traditional newspapers, it is possible to identify critical issues concerning the university student movements' purposes to implement breaking (and occasionally violent) methods to carry out the reforms that they promoted, according to the right-wing press. Against this backdrop, the different importance of an anti-communist component is discernible, typical of the Cold War period, in the (political and emotional) arguments of the newspapers under analysis.Originality/valueThis article proposes an interpretation that intertwines a local phenomenon (the reformist movement of the University of Chile) with a global one (the May student revolution of 1968). It also establishes a novel approach by linking, through its approach, yet traditional concepts of social and cultural analysis (the idea of social imaginaries) with a new emphasis on social science and humanities (emotional dimensions).
The effects of trade unions on economic performance: evidence from Chinese provincial-level data
Authors: Guo Rui , Laroche Patrice 
Published: December 2020

PurposeThe purpose of this study is to investigate union effects on wages, employment, and productivity in China. The relationships between unionization and these three economic variables are first tested at the national level and then examined in the eastern, central, and western regions, respectively.Design/methodology/approachProvincial-level panel data from 1994 to 2014 are used in this study, compiled from various Chinese Statistics Year Books, and covering 29 provinces. The Ordinary Least Square is firstly employed to examine union impacts. Then, in view of the endogeneity of unionization, the Two-Stage Least Square estimation with instrument variables is adopted to reexamine union effects. Overidentification tests are conducted, verifying the validity of these instruments.FindingsAt the national level, Chinese unions have significantly positive effects on wages but no significant effect on employment and productivity. In the eastern region, unions are significantly related to increased employment. In the western region, union activity not only significantly promotes wages but also improves productivity. In the central region, unionization has no significant impact. These findings suggest that equipping Chinese unions with a collective and cooperative face can generally help them improve workers' interests. Their effectiveness varies across the three economic regions.Originality/valueCompared with the survey data conducted in certain cities and industries, the provincial-level panel data used in this article have the advantage of capturing the overall effects of unionization. An instrument variable method is used to address the endogeneity issue. After exploring union effects at the national level, this paper focuses on observing the differences in union roles in three economic regions.
A hub location model in the sustainable supply chain considering customer segmentation
Authors: Heidari Ali , Imani Din Mohammad , Khalilzadeh Mohammad 
Published: December 2020

Purpose
This paper aims to study the hub transportation system in supply chain networks which would contribute to reducing costs and environmental pollution, as well as to economic development and social responsibility. As not all customers tend to buy green products, several customer groups should be considered in terms of need type.

Design/methodology/approach
In this paper, a multi-objective hub location problem is developed for designing a sustainable supply chain network based on customer segmentation. It deals with the aspects of economic (cost reduction), environment (minimizing greenhouse gas emissions by the transport sector) and social responsibility (creating employment and community development). The epsilon-constraint method and augmented epsilon-constraint (AEC) method are used to solve the small-sized instances of this multi-objective problem. Due to the non-deterministic polynomial-time hardness of this problem, two non-dominated sorting genetic algorithm-II (NSGA-II) and multi-objective grey wolf optimizer (MOGWO) metaheuristic algorithms are also applied to tackle the large-sized instances of this problem.

Findings
As expected, the AEC method is able to provide better Pareto solutions according to the goals of the decision-makers. The Taguchi method was used for setting the parameters of the two metaheuristic algorithms. Considering the meaningful difference, the MOGWO algorithm outperforms the NSGA-II algorithm according to the rate of achievement to two objectives simultaneously and the spread of non-dominance solutions indexes. Regarding the other indexes, there was no meaningful difference between the performance of the two algorithms.

Practical implications
The model of this research provides a comprehensive solution for supply chain companies that want to achieve a rational balance between the three aspects of sustainability.

Originality/value
The importance of considering customer diversity on the one hand and saving on hub transportation costs, on the other hand, triggered us to propose a hub location model for designing a sustainable supply chain network based on customer segmentation.
Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome
Authors: Bergero Roberta , Ellis Peter , Haerty Wilfried , Larcombe Lee , Macaulay Iain , Mehta Tarang , Mogensen Mette , Murray David , Nash Will , Neale Matthew J. , O'Connor Rebecca , Ottolini Christian , Peel Ned , Ramsey Luke , Skinner Ben , Suh Alexander , Summers Michael , Sun Yu , Tidy Alison , Rahbari Raheleh , Rathje Claudia , Immler Simone 
Published: January 2021

ABSTRACTThe separation of germ cell populations from the soma is part of the evolutionary transition to multicellularity. Only genetic information present in the germ cells will be inherited by future generations, and any molecular processes affecting the germline genome are therefore likely to be passed on. Despite its prevalence across taxonomic kingdoms, we are only starting to understand details of the underlying micro‐evolutionary processes occurring at the germline genome level. These include segregation, recombination, mutation and selection and can occur at any stage during germline differentiation and mitotic germline proliferation to meiosis and post‐meiotic gamete maturation. Selection acting on germ cells at any stage from the diploid germ cell to the haploid gametes may cause significant deviations from Mendelian inheritance and may be more widespread than previously assumed. The mechanisms that affect and potentially alter the genomic sequence and allele frequencies in the germline are pivotal to our understanding of heritability. With the rise of new sequencing technologies, we are now able to address some of these unanswered questions. In this review, we comment on the most recent developments in this field and identify current gaps in our knowledge.
When do Janzen–Connell effects matter? A phylogenetic meta‐analysis of conspecific negative distance and density dependence experiments
Authors: Song Xiaoyang , Lim Jun Ying , Yang Jie , Luskin Matthew Scott 
Published: December 2020

AbstractThe Janzen–Connell (J‐C) hypothesis suggests that specialised natural enemies cause distance‐ or density‐dependent mortality among host plants and is regarded as an important mechanism for species coexistence. However, there remains debate about whether this phenomenon is widespread and how variation is structured across taxa and life stages. We performed the largest meta‐analysis of experimental studies conducted under natural settings to date. We found little evidence of distance‐dependent or density‐dependent mortality when grouping all types of manipulations. Our analysis also reveals very large variation in response among species, with 38.5% of species even showing positive responses to manipulations. However, we found a strong signal of distance‐dependent mortality among seedlings but not seed experiments, which we attribute to (a) seedlings sharing susceptible tissues with adults (leaves, wood, roots), (b) seedling enemies having worse dispersal than seed enemies and (c) seedlings having fewer physical and chemical defences than seeds. Both density‐ and distance‐dependent mortality showed large variation within genera and families, suggesting that J‐C effects are not strongly phylogenetically conserved. There were no clear trends with latitude, rainfall or study duration. We conclude that J‐C effects may not be as pervasive as widely thought. Understanding the variation in J‐C effects provides opportunities for new discoveries that will refine our understanding of J‐C effects and its role in species coexistence.
Drying in newly intermittent rivers leads to higher variability of invertebrate communities
Authors: Crabot Julie , Polášek Marek , Launay Bertrand , Pařil Petr , Datry Thibault 
Published: December 2020

Abstract

Aquatic invertebrate communities inhabiting intermittent rivers that are characterised by recurrent drying events (flow cessation or complete disappearance of surface water) often show rapid recovery upon flow resumption. Such rapid recovery is possible thanks to specific resistance and resilience traits that species adapted to river drying often exhibit. However, differences in community response to drying can be expected between historically drying (HD) networks—those IRs with a long history of flow intermittence—and recently drying (RD) networks, where drying is a novel, often human‐induced, phenomenon. The invertebrate species found in RD networks may lack the adaptations that are known to facilitate quick community recovery upon rewetting and could thus be dramatically affected by drying. Unfortunately, the responses of aquatic communities in RD networks are still poorly explored, limiting our capacity to predict and mitigate future biodiversity changes.

Here, we compared the responses of aquatic invertebrate communities to drying in nine pairs of intermittent and perennial river reaches from HD networks across France and nine pairs from RD networks across the Czech Republic. Using both taxonomic and functional perspectives, differences in α‐ and β‐diversity patterns between perennial and intermittent sites were evaluated separately for HD and RD groups, and before and after drying over several years.

Drying had stronger effects on taxonomic richness in RD compared to HD networks. In addition, drying greatly altered spatial and temporal β‐diversity in RD networks, but it marginally affected β‐diversity in HD networks. Communities of HD networks showed a higher proportion of resistant taxa than RD networks.

These results suggest that recent drying can have, at least on a short time scale (i.e. years), stronger effects on aquatic communities in RD networks compared to those in HD networks.

Because drying duration, frequency, and spatial extent are increasing with climate change, RD networks could soon reach tipping points, calling for long‐term monitoring of biodiversity in these novel ecosystems.
UV‐induced DNA damage disrupts the coordination between replication initiation, elongation and completion
Authors: Wendel Brian M. , Hollingsworth Suzanne , Courcelle Charmain T. , Courcelle Justin 
Published: December 2020

AbstractReplication initiation, elongation and completion are tightly coordinated to ensure that all sequences replicate precisely once each generation. UV‐induced DNA damage disrupts replication and delays elongation, which may compromise this coordination leading to genome instability and cell death. Here, we profiled the Escherichia coli genome as it recovers from UV irradiation to determine how these replicational processes respond. We show that oriC initiations continue to occur, leading to copy number enrichments in this region. At late times, the combination of new oriC initiations and delayed elongating forks converging in the terminus appear to stress or impair the completion reaction, leading to a transient over‐replication in this region of the chromosome. In mutants impaired for restoring elongation, including recA, recF and uvrA, the genome degrades or remains static, suggesting that cell death occurs early after replication is disrupted, leaving partially duplicated genomes. In mutants impaired for completing replication, including recBC, sbcCD xonA and recG, the recovery of elongation and initiation leads to a bottleneck, where the nonterminus region of the genome is amplified and accumulates, indicating that a delayed cell death occurs in these mutants, likely resulting from mis‐segregation of unbalanced or unresolved chromosomes when cells divide.
Survey on the attitudes of dental hygiene students towards treating elderly patients
Authors: Grandjean Marie‐Laure , Morier Chloé , Piccardi Carlotta , Srinivasan Murali 
Published: December 2020

AbstractObjectiveThis questionnaire‐based survey assessed the attitudes of dental hygiene students towards treating elderly patients.MethodsThe 14‐item UCLA 14‐item Geriatrics Attitudes Scale (GAS‐14) questionnaire was used in this survey. A further set of nine questions evaluated the opinions of the students towards the existing geriatric curriculum in their respective institutions. Students from five dental hygiene schools from three countries (Switzerland, Belgium and Canada) participated in this survey. General demographic information from the participants was collected. Mean GAS‐14 scores were calculated; ANOVA and Bonferroni's tests were used for statistical analyses (p < 0.05).ResultsThree hundred eighty‐five students (Switzerland: n = 157, mean age = 25.38 ± 4.6 years; Belgium: n = 82, mean age = 27.58 ± 12.8 years; Canada: n = 146, mean age = 25.95 ± 12.3 years) completed the survey for a response rate of 86.3%. The overall GAS‐14 scores for Switzerland, Belgium and Canada were 3.61 ± 0.42, 3.24 ± 0.37 and 3.32 ± 0.36, respectively. Switzerland scored significantly higher than Belgium and Canada (p < 0.0001). Overall scores revealed a significant effect of progressive training (p = 0.010). The GAS‐14 score was influenced by the nationality of the participants (p < 0.0001), but not influenced by sex, age, origin, religion, or marital and accommodation statuses. Majority of the students (75.8%) agreed that geriatric dentistry was an important part of their education. 77.4% agreed that they would like hands on experience in treating the elderly patient during their education. 85.1% of the participants considered mobile dental clinics as a good solution for the provision of dental care to the institutionalized elders.ConclusionsThe general attitudes of DH students towards treating the elderly patients are on an acceptable level and improved as they progressed through their dental hygiene academic programmes.
Acute kidney injury in COVID‐19: Identification of risk factors and potential biomarkers of disease in a large UK cohort
Authors: Phillips Thomas , Stammers Matthew , Leggatt Gary , Bonfield Becky , Fraser Simon , Armstrong Kirsten , Veighey Kristin 
Published: January 2021

AbstractBackgroundCOVID‐19 is associated with increased risk of acute kidney injury (AKI). Risk factors and biomarkers linked to AKI have now been recognized by national guidelines in the United Kingdom. This analysis aims to validate and expand the comorbidities and biomarkers associated with the presence and severity of AKI in these patients.MethodsData were extracted via structured query language for patients with COVID‐19 at University Hospital Southampton between 1 March and 10 June 2020. Demographics, comorbidities, common biomarkers and AKI stage within 48 hours of admission, peak during admission and the last measurement prior to patient outcome (discharge or death) were collected and statistically analysed.ResultsSix hundred and thirty‐two COVID‐19 positive patients were admitted during this period; 34.2% had an AKI during their entire admission, 20.3% had AKI stage 1, 8.5% stage 2 and 5.4% stage 3. This was higher when compared with data from the same period in 2019. AKI carried an increased risk of death, 50.0% vs 21.1% (P = <.001). AKI stage was significantly associated with age over 65, diabetes, heart failure, peripheral vascular disease, haematological malignancy, hypertension, respiratory rate, albumin, C‐reactive protein (CRP), d‐dimer, ferritin, high‐sensitivity troponin‐I, neutrophil count, total white cell counts, National Early Warning Score‐2 (NEWS‐2), Charlson comorbidity index and alanine‐aminotransferase. COVID‐19 specific treatment, including dexamethasone, reduced discharge creatinine.ConclusionCOVID‐19 increases the risk of AKI and this kidney injury may be responsive to treatment. This analysis identified that AKI is associated with both previously described and new comorbidities and biomarkers.
The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India
Authors: Koshy Roshine Mary , Thankaraj Shajin , Ismavel Vijay Anand , Solomi Carolin V. 
Published: January 2021

AbstractIn this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at‐risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies.