bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning curve and its effect on the results of transsphenoidal endoscopic surgery of pituitary adenomas
Authors: Cherebillo V. Yu. , Ryumina Yu. I. 
Published: December 2024

Introduction. Since the beginning of the development of the transsphenoidal approach, many practicing surgeons in their publications have emphasized the steep learning curve of this field, highlighting the difficulties that may arise for novice surgeons. Despite the evidence of the overall effectiveness and safety of endoscopic surgery, a variety of factors, as reported in the modern literature, affect the curves of surgical training in minimally invasive endoscopic methods, including transsphenoidal endoscopic surgery of the pituitary gland, and, accordingly, the results of surgical treatment.The objective of the work was the analysis of the results of treatment of patients diagnosed with pituitary adenoma by transsphenoidal endoscopic method for the period from 2019 to 2022 in experienced and inexperienced surgeons, the determination of the threshold for learning this method and ways to overcome it.Methods and materials. This article describes the statistical analysis of the results of treatment of patients diagnosed with pituitary adenoma by transsphenoidal endoscopy for the period from 2019 to 2022 in experienced and inexperienced surgeons, a review of the literature determining the learning curve of surgeons for this approach.Results. A neurosurgeon performing more than 200 transnasal operations per year had lower rates of endocrinological, ophthalmological and infectious complications, a lower frequency of postoperative liquorrhea, a higher rate of radicality of the operations performed, and shorter surgery time. However, it is important to note that for inexperienced surgeons performing less than 50 operations per year and with a total experience of less than 100 operations, the percentage of complications does not exceed the figures published in modern literature.Conclusion. The learning curve is a crucial factor in acquiring new manual skills. Understanding the relationship between the learning curve and surgical outcomes will allow surgeons to better understand what to expect and what measures to take as these surgical skills develop. It seems that the mastery of endoscopic surgery of the base of the skull must necessarily be carried out in a large specialized neurosurgical center, which has an expert-level neurosurgeon with experience of several thousand operations and performs at least 200 operations annually.
Influence of functional brain asymmetry on coordination stability of children with intellectual disabilities
Authors: Fedulova D. V. , Berdyugin K. A. 
Published: December 2024

Introduction. Coordination stability is expressed in psychomotor control of motor activity by the human nervous system and in postural balance as a consequence of cortical-subcortical regulatory processes. With mental retardation, there is a violation of the integrative activity of the higher parts of the brain, a violation of the synthesis and analysis of afferent information of all mental and motor functions, and a violation of spatio-temporal interactions. It is relevant to determine the lateralization of psychomotor processes in people with intellectual disabilities as one of the predictors of understanding the relationship between motor asymmetries in the context of the mechanisms of initiation and further regulation of motor actions.The objective was to determine the nature of lateralization of psychomotor processes in children with intellectual disabilities and to identify the degree of influence on coordination stability.Methods and materials. The study involved 40 children aged 14–15 years, who were divided into 2 groups: 20 children with mild mental retardation and 20 normotypical children from a secondary school. Identification of the individual profile of functional interhemispheric asymmetry included passing 7 tests to determine the functional asymmetry of the arms and 6 tests to determine the functional asymmetry of the legs. Also 2 tests for coordination stability.Results. In normotypical schoolchildren, right-sided lateralization predominates, which indicates the dominance of the left hemisphere. In schoolchildren with mental retardation, the coefficient of manual asymmetry revealed left-sided lateralization. These features are expressed, among other things, in motor manifestations; the regulation of motor actions in some cases is uncoordinated.Conclusions. There is no specific algorithm for psychomotor control that can be observed in normotypical schoolchildren; motor skills, as well as bilateral body coordination, have reduced development.
Study of the cytotoxic effect of secretory phospholipase A2 of Vipera nikolskii venom on the model of HeLа and ECV340 cell lines
Authors: Solovyeva M. A. , Galebskaya L. V. , Galkin M. A. , Shemchuk O. S. , Sharoyko V. V. , Vasina L. V. 
Published: December 2024

Snake venoms have long been the subject of research in order to obtain new antitumor compounds. Snake secretory phospholipase A2 has cytotoxic properties that are realized through different mechanisms depending on the enzyme structure and cell type. HeLa and ECV340 cells were used as a model to evaluate the toxic effect of sPLA2 in the venom of V. nikolskii with and without sPLA2 inhibition. Varespladib was used as an inhibitor of sPLA2. In order to understand the mechanism of the toxic effect of sPLA2, the enzyme was activated by adding an emulsion of phospholipids, bovine serum albumin, and Ca2+ to the samples. The results indicate that the cytotoxic effect of sPLA2 on ECV 340 cells is associated with the catalytic activity of the enzyme; the weak cytotoxic effect of the venom on HeLa cells was preserved upon enzyme activation.Thus, we have proposed a methodological approach that allows to evaluate the toxic effect of sPLA2, which has enzymatic activity, in the whole venom of V. nikolskii in relation to various cell lines.
The technique of retrograde CBCT-sialography in obstructive parotid salivary gland syndrome
Authors: Razumova A. Ya. , Zubareva A. A. , Yaremenko A. I. , Kutukova S. I. , Petrov N. L. 
Published: December 2024

Introduction. Diagnosis of obstruction of the ductal system of the salivary glands is a difficult task. Standard research methods cannot detect such pathology. CBCT-sialography is a modern technique that will simplify and increase the informative value of diagnostics compared to an X-ray image.The objective was to study the possibility of visualizing the ductal system of the salivary glands by retrograde administration of a contrast agent using ultrasound navigation to perform cone beam tomography (CBCT-sialography).Methods and materials. On the basis of the oncological Department № 8 of the FSBEI HE I. P. Pavlov SPbSMU MOH, the patient underwent the installation of a subclavian catheter under ultrasound control into the duct expansion cavity through the skin. Next, a radiopaque preparation was introduced, and a cone-beam computed tomography of the maxillofacial region was performed.Results. Based on the results of the study, surgical intervention was performed. During control examinations, no pathological changes in the ductal system of the parotid salivary gland were detected.Conclusion. This article describes a clinical case of the successful use of CBCT-sialography. This technique with a low radiation load has shown high informativeness and can be performed on an outpatient basis. Therefore, it is necessary to accumulate clinical material to evaluate the effectiveness of the technique in various pathological changes in the salivary glands.
Mengukur Efek Marjinal dan Elastisitas Permintaan Transjakarta dan Jaklingko dengan Multinomial Logit Model
Authors: A.T.D., M.Sc.(Eng). Dr. Masrono Yugihartiman, , Ariani Firga 
Published: December 2024

Wacana kenaikan tarif BRT Transjakarta yang ditetapkan sejak tahun 2005 sering muncul di media masa. Untuk memberikan evidence response penumpang terhadap tarif tersebut, penelitian ini dilakukan. Adapun tujuan penelitian ini adalah untuk mengestimasi efek marjinal dan elastisitas permintaan dua jenis pelayanan, yaitu BRT Transjakarta dan Jaklingko. Metode penghitungan efek marjinal dan elastisitas menggunaknan multinomial logit model (MNL) dan conditional logit model (CLM). Pengumpulan data dilakukan dengan menggunakan stated preference survey terhadap 1.202 responden, yang terdiri dari 621 responden BRT Transjakarta dan 581 responden Jaklingko. Berbeda dengan penelitian yang pernah dilakukan di Jakarta sebelumnya, penelitian ini langsung mengestimasi tarif, waktu perjalanan, waktu menunggu, dan biaya transportasi kendaraan pribadi. Selain itu, penelitian ini juga menganalisis efek marjinal dan elastisitas terhadap tingkat pendapatan pengguna secara langsung, yaitu dengan memasukkan tingkat pendapatan di dalam model, dan juga membuat model yang berbeda untuk tingkat pendapatan yang berbeda. Dari hasil penelitian, ditemukan efek marjinal permintaan BRT Jakarta rata-rata -0,0187, dengan elastisitas sekitar -0,0757, yang menunjukkan elastisitas pernintaan terhadap tarif tidak elastis. Demikian pun terhadap waktu perjalanan dengan efek marjinal sekitar separuh dari tarif, yaitu -0,0085 dan elastisitas -0,9074. Untuk waktu tunggu, efek marjinal sekitar dua kali dibandingkan waktu tempuhnya, yaitu sebesar -0,0165, dengan elastisitas -0,0780, dan untuk biaya perjalanan kendaraan pribadi dengan efek marjinal 0,0011 dan elastisitas 0,0848. Sedangkan untuk tingkat pendapatan dengan efek marjinal 0,0061, atau permintaan akan meningkat 0,61% setiap terjadi Rp 1 juta peningkatan pendapatan pengguna, dengan elastisitas 0,0546. Efek marjinal dan elastisitas ini menurun pada tingkat pendapatan yang lebih tinggi. Hal yang sama terjadi pada pelayanan Jaklingko. Secara umum, efek marjinal dan elastisitas Jaklingko lebih tinggi dibandingkan dengan BRT Transjakarta.
Analisis Nilai-nilai Pendidikan dalam Novel Dunia Kecil yang Riuh Karya Arafat Nur
Authors: Syifauddin Achmad , Kusmiyati  , Utami Sri , Martono Boedi , Heni Tahira Ketin Ayu 
Published: December 2024

Penelitian ini bertujuan untuk mendeskripsikan bentuk nilai-nilai pendidikan yang terdapat dalam novel Dunia Kecil yang Riuh karya Arafat Nur. Adapun nilai-nilai tersebut meliputi; (1) nilai-nilai pendidikan ketuhanan, (2) nilai-nilai pendidikan moral, (3) nilai-nilai pendidikan sosial, (4) nilai-nilai pendidikan budaya, dan (5) nilai-nilai pendidikan estetika. Penelitian ini merupakan penelitian deskriptif kualitatif, deskriptif interpretatif dan analisis konten atau analisis isi. Subjek penelitian ini adalah novel Dunia Kecil yang Riuh karya Arafat Nur. Penelitian ini difokuskan pada permasalahan yang berkaitan dengan analisis nilai-nilai pendidikan dengan pendekatan pragmatik. Data dianalisis dengan teknik deskripsi kualitatif. Hasil penelitian menunjukkan sebagai: (1) bentuk nilai-nilai pendidikan ketuhanan terdapat 9 karakter (2) bentuk nilai-nilai pendidikan moral terdapat 16 karakter. (3) bentuk nilai-nilai pendidikan sosial terdapat 10 karakter. (4) bentuk nilai-nilai pendidikan budaya terdapat 14 karakter. (5) bentuk nilai-nilai pendidikan estetika terdapat 2 karakter
Исследование потенциала применения сквозных технологий в развитии информационной инфраструктуры города
Authors: Патриевская О.П. , Митягин С.А. 
Published: December 2024

Развитие современных городов тесно связано с информационными технологиями, внедрение которых позволило ускорить и упростить многие процессы взаимодействия горожан с органами власти и бизнесом. Однако, короткий период жизни современных информационных технологий, и часто отраслевая фокусировка развития информационной инфраструктуры современных городов все чаще приводит к необходимости реинжиниринга и преобразования этой инфраструктуры. Значимую роль в этом играют прорывные информационные технологии, которые одновременно являются источником технологического риска и потенциалом развития. В этой статье авторы рассматривают проблематику внедрения прорывных технологий в условиях сложившейся информационной инфраструктуры, риски и ожидаемые эффекты.
The development of modern cities is closely connected with information technologies, the introduction of which has made it possible to speed up and simplify many processes of interaction of citizens with authorities and business. However, the short life span of modern information technologies, and often the industry focus on the development of information infrastructure of modern cities increasingly leads to the need for reengineering and transformation of this infrastructure. A significant role in this is played by breakthrough information technologies, which are both a source of technological risk and a potential for development. In this article, the authors consider the problems of introducing breakthrough technologies in the conditions of the existing information infrastructure, risks and expected effects
Развитие методов электронного обучения в контексте цифровых гуманитарных наук
Authors: Гаевская Е.Г. , Борисов Н.В. , Шадиев Р.Н. 
Published: December 2024

В статье рассматриваются возможности внедрения проектного метода в университетское образование в переходный период от офлайн-обучения к онлайн-обучению. Проанализированы требования к образовательной среде, диктуемые особенностями ее цифровизации и автономизации студентов. Педагогические аспекты рассматриваются в контексте междисциплинарных подходов цифровых гуманитарных наук как содержания обучения и методов обучения. Такой подход к педагогике высшего образования позволяет повысить качество обучения и обеспечить успешное овладение студентами компетенций, необходимых специалистам цифрового обществаю В статье представлены результаты эксперимента по использованию проектного метода, который проводился в рамках педагогической деятельности кафедры информационных систем в искусстве и гуманитарных науках Санкт-Петербургского государственного университета в 2018-2021 годах. Полученные результаты свидетельствуют о том, что подходы цифровой гуманитарной педагогики способствуют более эффективному развитию у студентов компетенций специалиста в цифровом обществе.
The article discusses the possibilities of the project method implementing to the university education in the transition period from offline to online training. The requirements for the educational environment dictated by the peculiarities of its digitalization and students autonomization are analyzed The pedagogical aspects are considered in the context of the interdisciplinary approaches of digital humanities as learning content and teaching methods. Such approaches to the higher education pedagogy allows to improve the quality of education and ensure the successful mastering by students of the competencies necessary of the digital society specialists. The article presents the results of an experiment on the use of the project method, which was carried out as part of the pedagogical activities of the Department of Information Systems in Art and Humanities of the Faculty of Arts of St. Petersburg State University during 2018-2021. The results obtained indicate that the approaches of digital humanitarian pedagogy contribute to the more effective development of students' competencies of a specialist in a digital society.
Отношение к цифровому волонтерству российской молодежи
Authors: Молчанов С.В. , Алмазова О.В. , Поскребышева Н.Н. 
Published: December 2024

В статье рассматриваются особенности отношения современной российской молодежи к цифровому волонтерству. Проанализированы особенности развитие возможностей волонтерской активности в современной России, рассмотрена мотивация волонтерства, роль участия в волонтерской активности для соматического и психологического благополучия человека. Определено понятие цифрового волонтерства, выделены его ключевые особенности, указаны возможные направления реализации, рассмотрено и соотнесено со смежными понятиям (например, рефлексирующее волонтерство). Проанализированы результаты исследования, направленного на изучение особенностей отношения к цифровому волонтерству и мотивации добровольчества российской молодежи. В исследовании приняли участия 284 школьников и студентов в возрасте от 14 до 23 лет. Были использованы 2 методики для сбора данных. Полученные результаты позволили определить представлений молодежи о преимуществах и недостатках цифрового волонтерства и специфику ориентировку в них. Были выявление три типа мотивации волонтерства: «активные волонтеры», «прагматичные волонтеры», «пассивные волонтеры». Был проведен анализ связи между представлениями о преимуществах и недостатках цифрового волонтерства и типом мотивации волонтерской активности. Полученные результаты позволили определить ключевые особенности отношения российской молодежи к цифровому волонтерству.
The article examines the features of modern Russian youth towards digital volunteering. The features of the development of opportunities for volunteer activity in modern Russia are analyzed, the motivation of volunteering, the role of participation in volunteer activity for the somatic and psychological well-being of a person is considered. The concept of digital volunteering is defined, its key features are highlighted, possible directions of implementation are indicated, considered and correlated with related concepts (for example, reflective volunteering). The results of a study aimed at studying the characteristics of attitudes towards digital volunteering and motivation for volunteering of Russian youth are analyzed. The study involved 284 schoolchildren and students aged 14 to 23 years. Two techniques were used to collect the data. The results obtained made it possible to determine the ideas of young people about the advantages and disadvantages of digital volunteering and the specifics of orientation in them. Three types of volunteering motivation were identified: “active volunteers”, “pragmatic volunteers”, “passive volunteers”. An analysis was made of the relationship between perceptions of the advantages and disadvantages of digital volunteering and the type of motivation for volunteering. The results obtained made it possible to determine the key features of the attitude of Russian youth to digital volunteering.
Интернет и современное общество: специальный номер журнала INJOIT по результатам проведения Юбилейной XXV Международной объединенной научной конференции IMS-2022
Authors: Чугунов А.В. , Прокудин Д.Е. 
Published: December 2024

В данный специальный номер журнала "International Journal of Open Information Technologies" включены статьи, которые были подготовлены по итогам выступления на конференции "Интернет и современное общество" (IMS-2022) и отмечены её организаторами.
This special issue of the International Journal of Open Information Technologies includes articles that were prepared following a speech at the Internet and Modern Society (IMS-2022) conference and noted by its organizers.
Развитие электронного взаимодействия клиники и пациента: опыт создания и тестирования чат-бота в медицинском центре
Authors: Калинин П.С. , Орлов Г.М. 
Published: December 2024

Статья посвящена рассмотрению современных тенденций цифровизации взаимодействия медицинского центра с пациентами, а также практическому вопросу разработки таких сервисов для пациента, реализуемых с помощью диалогового чат-бота. Приводится описание логики взаимодействия пользователя с чат-ботом, рассматриваются результаты первого бета-тестирования разработанного функционала и выводы о необходимых доработках по результатам проведенного опроса. Чат-бот создается в рамках проекта «цифровая клиника» по совершенствованию электронного взаимодействия клиники и пациента в СЗОНКЦ им. Л.Г. Соколова. Также рассматриваются перспективы и специфика взаимодействия медицинского центра с пациентами старшего возраста. В дальнейших планах авторов – проведение доработки чат-бота, запуск его в постоянную эксплуатацию, сбор обратной связи от пациентов об использовании чат-бота и проведение регулярного анкетирования пациентов. Планируется проводить специализацию интерфейсов чат-бота для различных возрастов, например, это представляется целесообразным для старшего поколения, которому с одной стороны, нужны более простые интерфейсы, с другой стороны, в связи с более частым наличием хронических заболеваний, требуется более адресное взаимодействие.
The article is devoted to modern trends of the electronic interaction between healthcare institution and patients, as well as to the practical issue of developing services for the patient, implemented using chatbot. The description of the logic of user interaction (userflow) with the chatbot is given. The results of the first beta testing of the developed functionality and conclusion about the necessary improvements are provided. The chatbot is being created as the part of the “Digital Clinic” project to improve clinic-patient electronic interaction at the Northwest District Scientific and Clinical Center named after L. G. Sokolov FMBA of Russia. The perspectives and specifics of the interaction with elderly patients are also demonstrated. Authors plan to make necessary improvements to the chatbot, launch it into permanent operation and collect feedback from patients about the use of the chatbot on the regular basis. It is also planned to specialize chatbot interfaces for different ages.