bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recombinant human G-CSF production as a protein based drug candidate for hematology and oncology
Authors: BOZKURT Yasemin , BİLGİN Sema , ERDEN Seçil , TURAN İsmail Furkan , GÖKÇE İsa 
Published: November 2019

The human granulocyte colony stimulating factor (hG-CSF) is a member of the CSF family. The first purpose of this study was production of recombinant human G-CSF (rhG-CSF) which is an important therapeutic protein for angiogenesis based clinical applicaitons. rhG-CSF was produced as inclusion body in the Escherichia coli strain BL21 (DE3) pLysE with pTOLT vector system. The rhG-CSF was purified by Ni-NTA agarose afinity chromatography and characterized with SDS-PAGE analysis. The effects of this therapeutic protein on cell viability was measured by MTT assay. Additionally, angiogenic potential of produced rhG-CSF was investigated via HUVEC cell line by in vitro scratch assay. As a result, the purified protein induced cell proliferation and the EC50 value of protein based drug candidate was 0.051 mM. Additionally, it was determined that the migration ability of the HUVECs was promoted by rhG-CSF in a concentration-dependent manner by in vitro scratch assay.
Safety of a Pulmonary Embolism Ambulatory Treatment Program
Authors: Hamad Mahir M. , Ellidir Elrasheed A. , Routh Charlotte , Wali Siraj O. , Connolly Vincent M. 
Published: November 2019

Objective: Evidence has emerged that out-patient management of pulmonary embolism may be an appropriate option in selected patients. This report is based on a safety data on a Pulmonary Embolism Ambulatory Treatment program.
Methods: An observational study in acute assessment unit from 2000-2006, of all consecutive patients with confirmed pulmonary embolism (high probability ventilation-perfusion scan or computerized tomography pulmonary angiography), have been evaluated. Exclusion criteria were oxygen saturation less than 92%; systolic blood pressure less than 100 mm Hg; significant cardiopulmonary or renal disease, and a bleeding risk. Patient treated initially with low molecular weight heparin followed by oral anticoagulants when diagnosis was confirmed and were assessed at 3 and 6 months.
Results: Sixty-one patients (33 females), median age 55 (range; 16-89 years) were eligible. Patients needed a maximum of 13 appointments. Risk factors included surgery (8.2%), cancer (8.2%), long travel (14.8%), previous thromboembolism (14.8%), hormonal replacement therapy (3.3%) and contraceptive pill (8.2%). No risk factor was identified at 37.7%. The mortality was zero at 6 months. No complications were recorded. Four patients required hospital admission, all within the first week; all were discharged within 24 hours. The median length of stay for patients with uncomplicated pulmonary embolism was 7 days; implementation of the pulmonary embolism ambulatory treatment program saved 427 bed days.
Conclusion: The pulmonary embolism ambulatory treatment program was cost-effective and was not associated with serious complications. Further evaluation of these programs could help establish the safety and cost-effectiveness of this approach.
The Incidence and Clinical Outcome of Cardiac Tamponade Following an Open Heart Surgery in a Developing Country
Authors: Misbah Abdalla , Pothineni Koteswara R. , Elshiekh Eman , Yousif Ali Yassir H. 
Published: November 2019

Introduction: Pericardial effusion is not uncommon following an open heart surgery, thus, it may progress to cardiac tamponade. This is a retrospective cross-sectional analysis evaluates the incidence, the potential perioperative and surgical risk factors causing cardiac tamponade following an open-heart surgery of patients during the period 2001-2006 at Ahmed Gasim Cardiac Center in Khartoum, North Sudan.
Methods: Diagnosis of cardiac tamponade was based on clinical and echocardiographic findings. Univariate analysis was performed to assess possible risk factors related to both, early and late cardiac tamponade.
Results: Among the 890 patients who underwent open heart surgery in this study, 47(5%) patients developed tamponade (early 49% or 51%). Early cardiac tamponade was found to be present with significant cardiac compromise and can easily be detected using echocardiography. In contrast the presentation of late cardiac tamponade, atypical and echocardiography was inconclusive. The mean age of patients was 31 ± 12 with slight female predominance. The main indication for the operation was rheumatic heart disease (89%), mainly mechanical valve replacement of the mitral valve. Eight (17%) patients were receiving warfarin preoperatively. Oozing wounds and blocked drains were encountered in 27% and 37%, respectively. About 6% of the patients recollect tamponade after decompression and one in-hospital death directly related to the cardiac tamponade.
Conclusion: Significant cardiac tamponade was associated with preexisting rheumatic heart disease, (preoperative warfarin use), mechanical valve replacement in the mitral position, oozing wounds and blocked drain. Echocardiography was reliable in early diagnosis, but not late, hemodynamically significant cardiac tamponade.
Different PEGylated Interferon Ribavirin Therapy in Non-Responders with Chronic Hepatitis C Virus Infection
Authors: Akbar Hisham O. 
Published: November 2019

Background: PEGylated interferon and ribavirin therapy is the current standard of care for patients with chronic Hepatitis C virus. It is unknown whether retreatment may be beneficial in non-responders.
Methods: Patients who failed to respond to either PEG-Intron or Pegasys with ribavirin were switched to a different PEGylated interferon with ribavirin.
Patients were assessed for virologic response by a decrease in viral load levels using a polymerase chain reaction assay. Only patients who had a negative viral load at week 24 were allowed to continue treatment for 48 weeks. Patients with a negative polymerase chain reaction assay after 6 months off treatment were considered as responders to the retreatment regimen.
Results: A total of 16 patients were retreated. The combination of Pegasys and ribavirin was administered to 3 patients, and 13 patients received PEG-Intron with ribavirin. Patients had either genotype 1 or 4. Only 4 patients responded to retreatment with PEG-Intron (25%).
The responders were female, had a low viral load and had an early significant viral load reduction. Three patients had genotype 4, and one had genotype 1.
Conclusion: Retreatment with different PEGylated interferon in patients who failed previous treatment may have a role in the selected patients infected with chronic Hepatitis C virus.
Drug Related Problems at the Intensive Care Unit of a University Hospital in Saudi Arabia
Authors: Randhawa Mohammad A. , Qutub Hatem O. , Alghamdi Mastour S. , Al-Jaizani Raniah A. , Mushtaq Rayan Y. , Akbar Mohammad J. 
Published: November 2019

Background: Medication errors can lead to mild or severe drug related problems. Drug related problems are sometimes unpredictable and can occur without medication errors. Awareness and identification of medication errors and drug related problems aids in adoption of measures to prevent and treat them.
Objective: Present study aimed to find out prevalence of drug related problems reporting or occurring at Intensive Care Unit of King Fahd Hospital of the University, Alkhobar, Saudi Arabia.
Methods: Scrutinizing written files of all patients reporting to Intensive Care Unit, from January to December 2012.
Results: Out of 193 files reviewed, 33 patients (17.1%) had trivial to serious drug related problems, including 8 (4.1%) deaths. Drugs commonly involved in these problems were anticoagulants (Warfarin and heparin, alone or in combination with aspirin or clopidogrel; 8 cases, 24.2%), antiepileptic drugs (Carbamazepine and phenytoin; 6 cases, 18.2%), immune suppressants (Azathioprine and prednisolone; 4 cases, 12.1%), antibiotics (Ciprofloxacin, imipenum, tazocin and vancomycin; 4 cases, 12.1%) and drugs of abuse and dependence (Alcohol, benzodiazepines, cannabis and opioids; 4 cases, 12.1%). Amongst drug related problems detected, 6 cases (18.2%) were linked to drug interactions. Almost 60% of drug related problems found were preventable, including those due to overdose toxicity, non-compliance and drug-drug interactions.
Conclusions: Mild to severe drug related problems occurred in intensive care unit of a university hospital and about half of them were preventable. It is hoped that the awareness and insight of drug related problems will help to improve patient care.
A Meta-Analysis Study: Vitamin D Deficiency in Saudi Arabia between 2009 and 2013
Authors: Bakarman Khalid A. , Bajubair Mohamad A. 
Published: November 2019

Objective: Our aim was to review the prevalence of vitamin D deficiency in Kingdom of Saudi Arabia in different areas done by many researches.
Methods: By systematic review with meta-analysis we collected the research performed in different areas of Saudi Arabia over the period of 2009-2013. This included both published papers (peer-reviewed) and papers presented at documented scientific conferences.
Results: Fourteen papers were found, thirteen of which were peer-reviewed and published and one had been presented in a conference. They covered five main areas in KSA, and pooling the numbers yielded 6478 total healthy participants. 4694 (72%) were in the least healthy range with deficiency levels < 20 ng/ml, and a total of 5355 (82.7%) were at levels below recommendations (< 30 ng/ml). The central region in Riyadh and Qassim cities represented the most investigated area including 2755 participants with 6 articles; followed by the western region, at Jeddah and Makkah cities, with 2239 participants.
The eastern region (2 articles in Dammam and Al Khobar cities with 339 participants) showed the lowest frequency of vitamin D deficiency at 29.2%, followed by the central region at 74%.
Conclusions: Despite adequate sunlight and adequate intake of dairy products, vitamin D deficiency appears to be a major health problem in the Saudi community. There are some geographic areas in the country that may be at high risk. Control strategies should take these differences into account.
Awareness of Eighth Joint National Committee Guidelines in Hypertension Management among Internists in Al-Ahsaa Area
Authors: Al-Kattan Abdullah N. 
Published: November 2019

Background: Hypertension is one of the most common conditions seen in primary care and the consequences are fatal if not diagnosed early and managed appropriately. Patients want to be sure that hypertension management will decrease their disease burden, and clinicians need guidance on hypertension treatment using the best scientific evidence. Objective: The primary objective is to evaluate the awareness of the Eighth Joint National Committee Guidelines among internists in the Al-Ahsaa area.
Method: This was a cross-sectional observational study that evaluated 43 internists randomly chosen in Al-Ahsaa area by using a questionnaire containing 16 questions that reflect on their awareness of the Eighth Joint National Committee Guidelines. Passing 80% of the 16 questions is described as fair awareness of the Eighth Joint National Committee Guidelines.
Results: The average of right answers percentages among the 43 evaluated internists was 54.07% ± 25.6%. The averages of right answers percentages among 16 physicians, 14 specialists and 13 consultants were 75.78% ± 20%, 47.76% ± 16% and 34.13% ± 20%, respectively, which showed a significant difference (P-value < 0.00001) between them.
Conclusion: The awareness of the Eighth Joint National Committee Guidelines among internists in Al-Ahsaa area is not good enough. However, physicians showed significantly better awareness of the Eighth Joint National Committee Guidelines than specialists and consultants. Increasing the awareness of internists about new guidelines for hypertension is highly recommended, through workshops that could be provided by the Ministry of Health.
Фактори, що сприяють удосконаленню та розширенню правового статусу людини, особистості та громадянина в умовах глобалізації
Authors: Kofman B. Ya. 
Published: November 2019

Правовий статус людини і громадянина як сукупність їхніх прав, свобод і обов’язків, що надані національною державою, є визначальною ознакою для розуміння відношення держави до людини. В умовах глобалізації, коли права людини стають об’єктом міжнародно-правової регламентації та регулювання, а їх виконання на території національної держави здійснюється через призму її міжнародно-правових зобов’язань, що передбачають можливість конвенційного контролю за виконанням таких зобов’язань, роль і значення правового статусу людини і громадянина суттєво зростає саме під впливом глобалізаційних процесів, що охоплюють міжнародне співтовариство, держави, їх народи та людей. Як наслідок, спостерігається трансформація та вдосконалення правового статусу людини і громадянина в бік його розширення.
Метою статті є дослідження факторів, що сприяють вдосконаленню та розширенню правового статусу людини, особистості та громадянина в умовах глобалізації.
Наукова новизна полягає у дослідженні та виокремленні факторів, що сприяють трансформації, вдосконаленню та розширенню правового статусу людини, особистості та громадянина в умовах глобалізації. За результатами дослідження виділено та проаналізовано 10 факторів.
Висновки. Трансформація, модернізація і розширення правового статусу людини і громадянина в умовах глобалізації відбувається завдяки складним соціальним (економічним, політичним, культурологічним, інформаційним, релігійним, екологічним) процесам вертикально-горизонтальної та міжгоризонтальної властивості, що супроводжують цей феномен, залучаючи до активної участі в них держави, народи та людей. З розвитком людства та державно організованого соціуму в умовах глобалізації потреби, інтереси, запити, життєві устремління людей піддаються суттєвому впливу з боку глобалізаційних процесів – вони, з одного боку, стають не тільки все більш різними, а й, з іншого боку, часом стосуються далеко не найбільш життєво важливих сфер людського життя, тобто таких, що загрожують фізичному існуванню людини або її благополуччю. Разом із тим слід відзначити, що ці потреби людей поступово все більше зсуваються у сферу духовну, де вирішуються питання самодосконалості людини, її фізичного та духовного зростання, що є вкрай важливим для сучасної людини. Правовий статус людини і громадянина, що встановлюється конкретною державою, не є статичною категорією, – він володіє високим динамічним потенціалом, завдяки чому активно реагує на глобалізаційні процеси, що скеровані на зміни гуманістичних і гуманітарних пріоритетів розвитку державності та міжнародної спільноти, шляхом його модернізації, вдосконалення і розширення.
SISTEM INFORMASI MONITORING KEGIATAN SANTRI BERBASIS ANDROID STUDI KASUS : PESANTREN AL-HIDAYAH GARUT
Authors: Sabar Muhamad , Heryanto Agus , Lestari Fuji 
Published: November 2019

Anak merupakan tanggung jawab orang tua yang di berikan oleh Allah S.W.T, oleh karena itu sudah sepatutnya orang tua harus menjaga dan mengawasinya, terutama ketika orang tua memutuskan untuk memasukan anaknya ke dalam sebuah pondok pesantren. Atas dasar itu terkadang waktu serta jarak yang jauh biasanya menjadi kendala utama orang tua dalam memperoleh informasi, ditambah lagi dengan keterlambatan pihak pesantren dalam memberikan informasi kepada orang tua santri. Dengan menerapkan teknologi informasi, maka pihak pesantren dapat lebih mudah dan cepat dalam memberikan informasi kepada orang tua santri, dan orang tua santri juga dapat turut serta mengawasi anaknya dalam hal memperoleh informasi yang berkaitan dengan Kegiatan santri, absensi santri dan pelanggaran yang dilakukan oleh santri.
Hasil dari penelitian ini adalah Aplikasi Monitoring Kegiatan Santri Berbasis Android menggunakan jenis penelitian kualitatif, sedangkan metode pengumpulan datanya menggunakan observasi, wawancara, dan studi literatur. Metode pengembangannya menggunakan metode waterfall dan pengujian aplikasi menggunakan metode black-box. Adapun kesimpulan yang diperoleh dari penelitian ini adalah aplikasi e-monitoring Al-Hidayah ini memudahkan orang tua dalam memperoleh informasi santri selama mondoksehingga orang tua dapat memperoleh data santri lebih detail
POSSIBILITY OF USING BLAST FURNACE SLAG IN CONCRETE AND MORTAR PRODUCTION IN VIETNAM
Authors: Ву Ким Зиен , Vu Kim Dien , Танг Ван , Tang Van , Баженова С. , Bazhenova S. , Нгуен Зуен Фонг , Nguyen Duyen Phong 
Published: November 2019

Blast furnace slag is a waste of metallurgical industry which can be used in production technology of concretes and mortars. The expedient use of blast furnace slag as a component for new building materials will improve the environmental situation and increase the economic efficiency of production. The authors reaserch blast furnace slag processing technology of factories "Hoa Phat" (Vietnam) and "Thai Nguyen" (Vietnam) to produce mineral additives. As a result of the conducted researches the chemical and mineralogical composition of slags are received, their physical and mechanical characteristics are considered and defined: specific surface area, density, water demand, and others.
According to standard of Vietnam and Russia, slag activity index is calculated when considering the possibility of using blast furnace slags to replace part of the binder. The relationship between the strength of the cement-sand mortar and density affected by the binder are reveald (where; binder = Portland cement + Granulated blast furnace slag). Comparison chart of slag activity index IR (%) has been shown.
The paper uses the Vietnamese standard TCVN 11586: 2016 to analyze the possibility of using blast furnace slag (Vietnam) in the technology of concrete and mortar construction.
Galician legends about miraculous sea-voyages in stone boats : Some Irish and Breton parallels
Authors: Alonso Romero Fernando 
Published: November 2019

Légendes galliciennes de voyages miraculeux dans des barques de pierre : Quelques parallèles irlandais et bretons .
S’il existe différentes légendes en Irlande, en Bretagne et en Galice de voyages miraculeux dans des barques de pierre, la distribution géographique des quatre légendes galiciennes concernant des saints ayant voyagé ainsi indique une relation maritime importante entre le Nord et le Sud de la côte de Galice. Ce type de légende n’apparaît en aucune autre région de Galice, ni au Portugal, ce qui confirme l’hypothèse selon laquelle ces légendes ne proviendraient pas de la Galice mais de Bretagne ou d’Irlande, et qu’elles sont probablement entrées en Galice avec l’arrivée des moines qui fondèrent l’abbaye, maintenant disparue, de Santa Maria de Britonia (Lugo).
Charlotte Brooke : A romantic metaphysical ?
Authors: Mac Craith Mícheál 
Published: November 2019

Charlotte Brooke, une poésie “métaphysique” d’époque romantique ?
Les Reliques of Irish Poetry (1789) de Charlotte Brooke marquent non seulement le début de la poésie anglo-irlandaise, mais aussi le passage de la poésie gaélique du support manuscrit à l’imprimé. En publiant les textes gaéliques originaux en regard de ses propres traductions, l’ouvrage de Ms Brooke était une dénonciation implicite du travail de James Macpherson. Cependant ses traductions anglaises manifestent sans cesse qu’elles ont sacrifié au charme conquérant de la prose de Macpherson, et au langage sentimental de la fin du XVIIIe siècle. Bien qu’elle suive fidèlement le contenu du texte original, Ms Brooke ne réussit pas à rendre le style et l’atmosphère de la poésie gaélique. L’auteur analyse les résultats du travail de Ms Brooke à propos d’un poème d’amour “courtois”, Féach orm, a inghean Eóghain, une composition très élaborée qui doit bien plus à l’inspiration “métaphysique” qu’à la passion.
Some neglected sources for middle Welsh phonology
Authors: Russell Paul 
Published: November 2019

Quelques sources jusque ici négligées pour la phonologie du Moyen-Gallois.
L’article met en valeur l’étude des noms propres gallois dans les rôles de la fin du XIIIe et du début du XIVe s., comme la Survey of the Honour of Denbigh, et dans les listes de subsides, comme le Merioneth Lay Subsidy Roll, et la contribution que ces documents peuvent fournir à notre connaissance de la phonologie du moyen-gallois. Sont discutés à la fois les avantages, inconvénients et difficultés trouvées dans l’interprétation de ces documents ; quelques exemples spécifiques sont examinés en détail.
Workshop Penelitian Tindakan Kelas Bagi Guru di Yayasan Darul Ulum Karangpandan Pasuruan
Authors: Hanifah Umi 
Published: November 2019

Abstrak:
Tujuan workshop ini pada khususnya diharapkan dapat meningkatkan atau memperbaiki kinerja belajar siswa di sekolah, meningkatkan mutu proses pembelajaran di kelas, meningkatkan kualitas penggunaan media, alat bantu belajar, dan sumber belajar lainnya, meningkatkan, memperbaiki maupun menjaga kualitas prosedur dan alat evaluasi yang digunakan untuk mengukur proses dan hasil belajar siswa. Selain itu, workshop ini juga dimaksudkan untuk membantu guru-guru dalam upaya peningkatan atau perbaikan terhadap masalah-masalah pendidikan anak di sekolah serta peningkatan dan perbaikan terhadap kualitas penerapan kurikulum dan pengembangan kompetensi siswa di sekolah. Metode yang digunakan dalam pelaksanaan pelatihan ini adalah metode ceramah, latihan, dan evaluasi. Secara umum, hasil pelaksanaan pengabdian pada masyarakat ini adalah cukup baik dan reponsif (dari rata-rata respons peserta pasca pelatihan sebesar 80,45% yang berada pada kategori positif) artinya terdapat pemahaman para guru tentang profesinya, terutama dalam hal pemahaman penulisan/ pembuatan/ pelaksanaan Penelitian Tindakan Kelas.

Kata Kunci: Penelitian Tindakan Kelas, Pembelajaran Siswa

Abstract:
The purpose of this workshop is in particular expected to be able to improve or improve student learning performance in schools, improve the quality of classroom learning processes, improve the quality of media use, learning aids, and other learning resources, improve, improve and maintain the quality of procedures and evaluation tools used to measuring the process and results of student learning. In addition, this workshop is also intended to assist teachers in efforts to improve or improve the problems of child education in schools and improve and improve the quality of curriculum implementation and the development of student competencies in schools. The method used in the implementation of this training is the method of lecture, practice, and evaluation. In general, the results of the implementation of community service are quite good and responsive (from the average response of participants after training at 80.45% which is in the positive category) meaning that there is an understanding of the teachers about their profession, especially in terms of understanding writing/making/implementation of Classroom Action Research.

Keywords: Classroom Action Research, Student Learning