bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAMONCO 2: Results From a Randomized Controlled Trial Comparing Open Dialogue About Complementary Alternative Medicine and Standard Care on Patients' Quality of Life
Authors: Stie Mette , Timm Signe , Delmar Charlotte , Nørgaard Birgitte , Jensen Lars Henrik 
Published: December 2024

The rising prevalence of complementary alternative medicine (CAM), including for example, dietary supplements, massage, and acupuncture, among patients with cancer underscores the necessity of integrating open dialogue about complementary alternative medicine (OD-CAM) into oncology treatment and care.

PURPOSE
This randomized controlled trial aimed to investigate the impact of OD-CAM on patients' quality of life (QoL), emotional well-being, decision regret, and survival. Patients undergoing antineoplastic treatment were randomly allocated to receive standard care (SC) plus OD-CAM or SC alone. The primary end point was patient-reported QoL 8 weeks after enrollment. Secondary end points included patient-reported QoL, anxiety, depression, and decision regret at 12 and 24 weeks after enrollment and overall survival at 52 weeks after enrollment.

MATERIALS AND METHODS
Patient-reported outcomes were evaluated using the European Organisation for Research and Treatment of Cancer Computer Adaptive Test Core questionnaire, the Hospital Anxiety and Depression questionnaire, and the Decision Regret Scale.

RESULTS
A total of 210 patients were equally randomly assigned, leaving 105 patients in each group. No significant differences were observed in QoL, well-being, decision regret, or survival between the groups.

CONCLUSION
OD-CAM did not demonstrate superiority over SC in enhancing the QoL and well-being of patients undergoing antineoplastic treatment. Increased levels of anxiety and fatigue might result from OD-CAM, underscoring the importance of the person-oriented approach inherent in OD-CAM. OD-CAM may hold clinical significance, especially for those already inclined toward CAM; however, further investigation into the essential components of OD-CAM and the characteristics of patients who are most likely to experience significant improvements of OD-CAM is recommended.
Chiaroscuro, Delaney's Aesthetic Vision, and Baldwin's “Sonny's Blues”
Authors: Miller D. Quentin 
Published: December 2024

In this chapter, D. Quentin Miller argues that James Baldwin’s 1957 short story “Sonny's Blues” was published at a point in his career when his attention to visual aesthetics was catalyzed and refined by Beauford Delaney. Reframing “Sonny’s Blues” in terms of its visual elements both affords a deeper understanding of Delaney’s influence on Baldwin and highlights the story’s essential concerns with the revelation of a complex psychological self. The complete self emerges through the interplay of lightness and dark, metaphorical indicators of the interplay between surface (the facets of others that we perceive) and depth (the mysterious facets hidden in one’s private interior). Chiaroscuro, the painting technique that corresponds to this verbal play, is at its core an artistic emphasis on the contrast and interplay of light and darkness to reveal depth and dimension.
A review on diagnosis and treatment approaches to calcium pyrophosphate deposition disease
Authors: Hosseinnejad Negar , Cygnarowicz Aleksandra , Wojtas Aneta Klaudia , Zabojska Krystyna , Korotko Urszula , Mandziuk Aneta , Witowska Kinga , Turemka Mariola , Biskupski Mikolaj , Sacher Karolina 
Published: December 2024

Introduction and purpose of this work
CPPD is an arthropathy related to calcium pyrophosphate crystals’ deposition in joints triggering an inflammatory response leading to local articular damage. CPPD mainly affects the large and weight-bearing joints.In this review paper, our aim is to outline the current knowledge on epidemiology, origins, clinical manifest, diagnostical tools, new guidelines of the (ACR) and (EULAR) and current treatment options for CPPD.
Methods:
We performed a systematic electronic search on PubMed, Medline and Google Scholar databases. The search results were limited to publications from 2002 to 2024, as well as key studies and reference books from earlier years.
Brief description of the state of knowledge
CPP crystals in joints can lead to an inflammatory response and lead to joint damage. CPPD is the third most common reason of arthritis. Its origin is rather idiopathic, but there has been research showing the linkage of this disease to genetical background and some metabolic disorders.The treatment is chosen based on the phenotype of the disease.conventional pharmacological treatment includes NSAIDs, colchicine and corticosteroids. New opportunities to CPPD treatment have appeared thanks to biological medications which inhibit the inflammatory process.
Summary
Early diagnosis of CPPD, distinguishing it from other forms of arthritis and identifying the possible co-occurring diseases such as gout, rheumatoid arthritis and osteoporosis can help the clinicians to apply the proper treatment . Most patients are seniors with several comorbidities, this is why it is important to choose the right treatment, which prevents exacerbation of the inflammatory process and ensures high quality of life for the patients.
The Impact of Excessive Sugar Consumption on Skin Health Analysis of Biological Mechanisms and Dermatological Effects
Authors: Dolata Natalia , Balcer Bartosz , Liszka Paweł , Pakuła Mateusz , Weimann Maja , Kruczkowska Adrianna , Stosiek Aleksandra , Cebula Agnieszka , Bulzacki Emil , Urbański Wojciech 
Published: December 2024

Introduction and purpose:
Excessive sugar consumption is one of the main dietary problem of the modern Western diet. Numerous studies have shown that a high intake of simple sugars is associated with an increased risk of developing various diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases. Moreover, the consumption of large amounts of sugar also affects skin condition, accelerating its aging and exacerbating the course of certain dermatological conditions. This study aims to present the underlying mechanisms of these processes and demonstrate the impact of a low-glycemic index diet on skin health.
Description of the state of knowledge:
The skin is the largest organ of the body, and its condition is closely linked to diet. Excessive sugar consumption can contribute to biochemical changes such as skin protein glycation, increased production of reactive oxygen species (ROS), and inflammation. The glycation process leads to damage of collagen and elastin fibers, which reduces skin elasticity and contributes to the formation of wrinkles. Elevated levels of MMP-1/MMP-2 and LOX in the skin can affect collagen fragmentation and disrupt its structural integrity. Studies have also shown that a high-glycemic index diet can exacerbate inflammatory conditions such as acne and psoriasis and promote hormonal imbalances.
Conclusion:
In summary, excessive consumption of simple sugars significantly affects skin condition through mechanisms such as glycation, inflammation induction, and hormonal disturbances. Therefore, a low-glycemic index diet may be an effective tool in the prevention and treatment of skin diseases. Future studies should focus on gaining a more precise understanding of these relationships and developing dietary recommendations to improve skin health.
The Use of Continuous Glucose Monitoring Systems in the Diagnosis and Monitoring of Gestational Diabetes Mellitus and Diabetes in Pregnancy - A Review of the Literature
Authors: Lenart Kacper , Kwaśna Julia , Załęska Adrianna , Bednarek Szymon , Kaźmierczyk Izabela , Górski Mateusz , Homza Michał , Bychowski Mateusz , Zakrzewska Natalia , Kulicka Joanna 
Published: December 2024

Background: Gestational diabetes mellitus (GDM) and preexisting diabetes present significant risks to maternal and neonatal health. Continuous glucose monitoring (CGM) has emerged as a valuable tool for optimizing glycemic control during pregnancy, offering real-time data and insights beyond traditional methods.
Objective: This review evaluates the role of CGM in the management and diagnosis of diabetes during pregnancy, focusing on its clinical efficacy, impact on maternal and neonatal outcomes.
Methods: A systematic literature search was conducted, covering studies published between 2017 and 2024. Inclusion criteria targeted studies assessing CGM in pregnant populations with GDM, T1D, or T2D. Data were synthesized to highlight maternal glycemic control metrics, neonatal outcomes, and limitations of CGM use.
Results: CGM, particularly real-time CGM (rt-CGM), significantly improves maternal glycemic control. Enhanced glycemic management has been associated with reduced risks of large-for-gestational-age (LGA) births, macrosomia, and preeclampsia, particularly in women with T1D.
Conclusion: CGM is a transformative tool in managing diabetes during pregnancy, providing critical insights into glycemic trends and enabling personalized care. While its benefits in improving maternal outcomes are clear, further research is needed to ensure equitable access.
Gut Microbiota and Mental Health: A Review of the Impact of Gut Bacteria on Depression and Anxiety Disorders
Authors: Pelczarska Aleksandra , Kaczorowski Rafal , Forenc Tomasz , Hunia Jaromir , Górny Julia , Janiszewski Michał , Jurek Jonasz , Komorowski Marcin , Kapciak Alicja 
Published: December 2024

The gut microbiota plays a crucial role in human health, including mental health. Depression and anxiety disorders are among the most common mental illnesses in the population. This review examines recent PubMed literature to evaluate the microbiota's impact on these conditions and potential therapeutic strategies. Gut microbiota affects depression and anxiety through neural, endocrine, and immune-inflammatory mechanisms, involving factors such as BDNF, elevated cortisol during dysbiosis, bacterial endotoxins, and cytokines. Conditions like leaky gut syndrome and SIBO are linked to the development of depression, anxiety, and other disorders, such as autism. Probiotics and prebiotics may alleviate depression by enhancing neuroplasticity, though this effect is better established in animal studies. For anxiety disorders, most studies report unfavorable alterations in gut microbiota composition among affected patients, while a few suggest a beneficial effect of probiotics. Probiotics also reduce side effects of antipsychotic drugs. Antibiotic use has been associated with increased risks of these mental conditions. Attempts have been made to use microbiota transfer therapy (MTT) as a complementary treatment, showing improvements particularly in depression and, to a lesser extent, anxiety, especially among patients recovering from COVID-19, those with irritable bowel syndrome (IBS), and individuals with severe depression. In recent years, numerous studies have explored the impact of gut microbiota on mental health, highlighting its significant therapeutic potential as an adjunct in treating anxiety and depression. However, there remains a need for more well-designed, large-scale human studies to confirm these findings conclusively.
Feeding habits of Gobiopterus brachypterus (Gobiiformes: Oxudercidae) in Ranu Grati Lake, East Java, Indonesia and their relationship with food availability
Authors: ANITASARI SEPTI , ARFIATI DIANA , SUSILO SUSILO , MARHENDRA AGUNG PRAMANA WARIH 
Published: December 2024

Abstract. Anitasari S, Arfiati D, Susilo, Marhendra APW. 2024. Feeding habits of Gobiopterus brachypterus (Gobiiformes: Oxudercidae) in Ranu Grati Lake, East Java, Indonesia and their relationship with food availability. Biodiversitas 25: 2925-2936. Ranu Grati, a volcanic lake located in Pasuruan District, East Java, Indonesia, is home to the endemic Gobiopterus brachypterus (Bleeker 1855) locally known as the lempuk fish. This research aims to elucidate the feeding habits of G. brachypterus and their relationship with food availability in Ranu Grati. The study investigates the food ecology of including their diet composition, habitat preferences, and feeding habits in relation to natural food availability including plankton abundance, relative abundance, uniformity index, dominance index plankton sampling was conducted at five stations by with the samples preserved in formalin and concentrated in the lab for analysis under a microscope. Fish were also collected at these stations using random sampling, dissected in the field, and their digestive tracts were preserved and later examined microscopically to identify the food types down to the lowest taxonomic level. The results reveal that the phytoplankton community in Ranu Grati Lake includes nine classes: Bacillariophyceae, Chlorophyceae, Cyanophyceae, Coscinodiscophyceae, Trebouxiophyceae, Dinophyceae, Zygnematophyceae, Raphidophyceae, and Euglenoidea. The zooplankton community comprises four classes: Monogononta, Copepoda, Branchiopoda, and Tubulinea. Phytoplankton in Ranu Grati Lake exhibit high diversity, with a diversity index of 3.739, and high uniformity, indicated by an evenness index of 0.957, showing no dominance (dominance index: 0.115). In contrast, zooplankton demonstrate moderate diversity (diversity index: 2.528), moderate evenness (evenness index: 0.647), and similarly show no dominance (dominance index: 0.216). The relative lengths of the intestines of G. brachypterus. are 0.163 and 0.132, indicating a carnivorous diet. The index of preponderance values highlights that Bacillaria sp., Oscillatoria sp., Microcystis sp., Oocystis sp., and Volvox sp. are significant dietary components for G. brachypterus, whereas Pinnularia sp., Entomoneis sp., Cymbella sp., Thalassiosira sp. and others contribute minimally or are absent. This highlights the dietary preferences of G. brachypterus. The stomach contents confirm that G. brachypterus exhibit a preference for phytoplankton, demonstrating opportunistic, carnivorous feeding behavior based on the availability of food in their natural environment.
Hospitalization costs and out-of-pocket (OOP) payment in lung cancer patients in Iran: Health Sector Evolution Plan (HSEP) has reduced OOP payments and improved financial protection
Authors: Jalilian Habib , Heydari Somayeh , Javanshir Elnaz , Jamebozorgi Khosro , Mir Nazanin , Eshraghi Abbas , Fehresti Saeedeh 
Published: December 2024

Background and objective
In Iran, Health Sector Evolution Plan, the most significant reform in the healthcare system in recent decades, has been launched since 2014 with the objective of achieving universal health coverage, decreasing out-of-pocket health expenditures and improving access to health services in hospitals and clinics affiliated to the Ministry of Health and Medical Education (MOHME). This study aimed to estimate the hospitalization costs of lung cancer and the impact of HSEP on hospitalization costs of lung cancer and patients’ contribution in Iran between 2010 and 2017.

Methods
This was a prevalence-based cost of illness study with a bottom-up costing approach. The sample size included 1778 lung cancer patients hospitalized in the Imam Reza hospital in Tabriz, Iran, between May 5, 2010, to May 5, 2014, and four years after the implementation of Health Sector Evolution Plan: from May 5, 2014, to May 5, 2017. The analysis was conducted from a societal perspective. Data were extracted from the electronic medical records of patients and were analyzed using SPSS V22.0, STATA V13.0 and Microsoft Excel 2016. The Interrupted Time-Series design was applied to estimate the impact of the implementation of HSEP on hospitalization costs and patient contribution rate for reimbursement of costs.

Results
The mean hospitalization costs of lung cancer before and after the implementation of Health Sector Evolution Plan was estimated at 2860 ± 4575 and 5300 ± 8880 PPP (Current International $), respectively. Moreover, the amount of out-of-pocket payments reduced from 705 PPP (Current International$) (22.16%) before the implementation of Health Sector Evolution Plan to 480 PPP (Current International $) (10.5%) after its implementation. the hospitalization costs went up moderately before the HSEP (increased from 2320 $ in 2010 to 3025 $ in 2013). After the HSEP, it continued to rise, but with a more significant increase until 2016. Then, in 2016, it reached a peak (6395 $) before dropping in 2017 (5005 $). Regarding patient contribution, before the HSEP, the percentage of patient contributions increased from 19.45 in 2010 to 24.28 in 2013. With HSEP’s implementation, this fell dramatically to 14.47 and continued to decline, reaching 7.99% in 2016. In 2017, patient contribution increased again and reached 9.58%.

Conclusion
Overall, hospitalization costs experienced an upward trend over the course of study, but this trend considerably intensified further after the HSEP. The patient contribution demonstrated an upward trend before HSEP, followed by a significant decline post-HESP, and the percentage of out-of-pocket payments reduced after implementation of HSEP. Therefor this plan has been successful in achieving the goal of financial protection of patients.
Preparation of molecular imprinted fluorescence sensor based on Er3+/ZnS QDs and its selective detection of ciprofloxacin in various matrices
Authors: Li Shuang , Wang Haijun , Wang Jinghan , Xu Feng , Li Hongmei 
Published: December 2024

Background
Ciprofloxacin is a widely used antibiotic in medicine and agriculture. It can cause pollution to the environment and food, thereby affecting human health.

Objective
This study proposes the preparation of molecular imprinted fluorescent sensors and their selective detection of ciprofloxacin, with the aim of achieving specific recognition and accurate detection of ciprofloxacin.

Methods
Rare earth metal Er3+ is added to ZnS quantum dots to prepare a molecularly imprinted fluorescence sensor (MIP/Er3+/ZnS QDs). The effects of substance concentration, pH value, and time on the fluorescence detection intensity are analyzed to determine the optimal fluorescence detection conditions.

Results
Experimental results showed that the sensor accurately detected ciprofloxacin with a detection limit of 31 nmol/L and the linear range of 0.1–10 μmol/L. The sensor had a recovery rate of 99.7% to 103.5% for ciprofloxacin in milk samples, with a relative standard deviation of less than 5%, indicating accurate determination of ciprofloxacin content.

Conclusion
Molecularly imprinted fluorescent sensors have enormous application potential in the monitoring and control of ciprofloxacin, and are of great significance for ensuring environmental and food safety.
Effect of physiotherapy interventions on pain management, function and quality of life in patellofemoral pain syndrome: A systematic review protocol
Authors: Vikhe Chaitali S. , Ramteke Swapnil U. , Hullumani Sharath 
Published: December 2024

Background
Patellofemoral pain syndrome (PFPS) is a prevalent and often debilitating condition, affecting approximately 22.7% of the population and significantly contributing to knee-related disorders. It primarily impacts young athletes and sedentary individuals, impairing their quality of life and functional abilities. Despite extensive research, the optimal management strategies for PFPS remain contentious due to its multifactorial etiology and persistent symptoms. The findings of this review will guide clinical practice and future research, ultimately improving outcomes for individuals with PFPS.

Objective
This systematic review aims to evaluate the effectiveness of physiotherapy interventions in alleviating pain, enhancing functional outcomes, and improving the quality of life among runners who have been diagnosed with PFPS.

Methods
This review will be carried out on randomized controlled trials (rcts) that assess any type of physiotherapy intervention for PFPS in runners. Eligible studies must report on pain intensity, functional improvement, or quality of life outcomes. Searches will be conducted in pubmed/MEDLINE, Cochrane Library, and pedro, covering publications from May 2014 to April 2024. Two reviewers will independently screen and select studies, extract data, and assess quality using the Cochrane Risk of Bias tool. We will perform a narrative synthesis of the data, focusing on pain management, functional recovery, and quality of life improvements. Sensitivity and subgroup analyses will explore variations across study designs and participant characteristics.

Conclusion
This systematic review protocol seeks to identify effective physiotherapy interventions for managing PFPS in runners. By analyzing rcts, the review will provide evidence-based recommendations to reduce pain, improve function, and enhance quality of life. The findings will guide clinical decisions

Systematic review registration
International Prospective Register of Systematic Reviews (PROSPERO) under ID: CRD42024531888.
Date- 7/05/2024, URL https://www.crd.york.ac.uk/prospero/#recorddetails.
Influence of the degree of lignification and use of indole-acetic acid on the development and rooting of Libidibia ferrea cuttings
Authors: Macia Ruiz Gloria Cecilia , Da Silva Daniel , Barbosa Sampaio Paulo de Tarso Barbosa Sampaio 
Published: December 2024

Libidibia ferrea (Mart. ex Tulle.) L.P. Queiroz, commonly known as pau-ferro and belonging to the Fabaceae family, is a species valued in traditional Brazilian medicine, promoting research in pharmacological and biotechnological products. However, seed propagation faces obstacles due to seed coat dormancy, which reduces germination rates, and genetic variability, which can lead to biochemical differences in compounds of interest, complicating standardization for the pharmaceutical industry. Thus, vegetative propagation emerges as a promising alternative to overcome these challenges. In this context, this study evaluated the effect of juvenility and indole acetic acid (IAA) on the rooting of L. ferrea cuttings, in addition to anatomical characterization of the cuttings to identify potential barriers to rooting. The experiment was conducted at INPA, Manaus – AM, using regrowth and juvenile cuttings prepared with one or two leaves cut in half and treated with IAA at concentrations of 0, 500, 1000, and 2000 mg L-1. After 60 days in a rooting greenhouse, the results show that regrowth cuttings had higher leaf retention (78.8%), callus formation (84.6%), rooting (65.4%), and average root number (3.0), underscoring the influence of tissue rejuvenation on rooting success. Juvenile cuttings exhibited greater bud formation (59.6%) and survival rate (86.5%), indicating that juvenility favors budding and survival. Therefore, the propagation of L. ferrea by cutting is viable and is enhanced when combined with rejuvenation techniques and the application of IAA, especially at a dose of 1000 mg L⁻¹.