bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ontologies and Technologies for Integrating and Accessing Digital Cultural Heritage: Lithuanian Approach
Authors: Varnienė-Janssen Regina , Šermokas Albertas 
Published: May 2020

Web technologies are the key for the implementing and ensuring the full range of user needs in the digital age. On the other hand, the issue of unified representation of digital content from diverse memory institutions in order to ensure semantic integrity still remains a matter of urgency. Semantic interoperability of information and data is essential in an integrated system. In this paper, we analyze and describe an ontology-based metadata interoperability approach and how this approach could be applied for memory institution data from diverse sources which do not support ontologies. In particular, we describe the use of the CIDOC CRM ontology as a mediating schema within Lithuania’s Information System of the Virtual Electronic Heritage (hereinafter ”VEPIS”) The paper introduces the role of the CIDOC CRM based Thesaurus of Personal Names, Geographical Names and Historical Chronology (hereinafter “BAVIC”), which operates as a core ontology within VEPIS by allowing to understand things and relationships between things as well as identify the time and space of things. The paper also focuses on trust of the cultural information on the Web. Users make trust judgments based on provenance that may or may not be explicitly offered to them. In particular, we describe how provenance is managed within digital preservation and access processes within VEPIS and define whether this management meets the W3C Provenance Incubator Group’s Requirements for Provenance on the Web. The paper is based on the results of the research initiated in 2018–2019 at the Faculty of Communication and the Faculty of Mathematics and Informatics of Vilnius University by authors of this paper.
The effect of additive containing an organic form of iodine on the physiological-biochemical parameters of the body of cows
Authors: Bogdanova A. A. , Alekseev A. A. , Flerova E. A. , Konovalov A. V. 
Published: May 2020

Iodine deficiency in soil and water in many countries leads to its low content in plants and animal feed produced from them. The limited intake of this element in animals can lead to endemic diseases. The lack of iodine in animal feeding is most often compensated for by the use of additives with an inorganic form of iodine, which can be poorly absorbed by the body. Feed products with an organic form of iodine have a great biological effect. A study on the effect of iodine-containing additives on the physiological and biochemical parameters of the animal organism was carried out on two groups of 15 cows. The experimental group was fed an organic form of iodine as part of the additive, the control group received an inorganic form of iodine. For all animals during the experiment the biochemical parameters of blood, milk productivity and reproductive ability were studied. During the experiment, an increase in metabolic and redox processes in the body was noted in the experimental group. An increase in mineral metabolism, including iodine content, was found. Due to the sufficient intake of organic iodine in the animals of the experimental group, there was an increase in the activity of the main hepatic enzymes AST and ALT. An increase in the process of gluconeogenesis due to an increase in the glucose content in the blood of experimental cows was revealed. An increase in milk production and reproductive function of animals of the experimental group was established. Within 30 days after the termination of feeding the supplement with the organic form of iodine in the experimental group, a prolonging effect was observed, consisting in higher values of blood biochemical parameters, improved reproductive function and milk productivity relative to equivalent animals in the control. As a result, it was concluded that the use of an additive with an organic form of iodine in the amount of 1.5 g in feeding cows for 60 days increases the iodine content in the blood serum of animals and increases the performance of all types of metabolism, which may indicate the best stimulating effect of the organic form of iodine on thyroid activity glands. This in turn helps to improve the productive and reproductive qualities of animals. To recommend the studied drug as a means to replenish iodine deficiency in animals and to more accurately analyze its effect on the hormone-forming function of the thyroid gland, it is necessary to study the level of thyroid hormones in the blood.
Event-related potentials during contralateral switching over motor programs in humans
Authors: Korzhyk O. V. , Dmutrotsa O. R. , Poruchynskyi A. I. , Morenko A. H. 
Published: May 2020

The study of processes related to the motor response suppression and the evaluation of the next, alternative, response after termination of the already observed initial motor response is of significant interest to modern scientists. The objective of our research is to identify the gender-specific features of the amplitude-time characteristics of induced cortical electrical activity in the process of the excitation of the motor programs of manual movement. Healthy and right-handed men and women aged 18–23 participated in the research. The research tasks investigated the time of simple and complex visual-motor responses, amplitude-temporal features of N2 and P3 components of cognitive evoked potentials in the response to launch and contralateral switching (dominant or subdominant arm) of the motor program of finger flexes (pressing the remote control button) in the Stop-Change paradigm. Event-related potentials (ERPs) were analyzed in the frontal, central, and parietal lobes of the cortex. It was established that male participants had lower time indexes of simple and complex visual-motor responses than women. In addition, during the contralateral switching of motor programs of manual movements the smaller latent periods of the ERPs components in the right central and left frontal sections (component N2), in the left hemisphere lobes (component P3) among men were observed. The amplitudes of the N2 and P3 components revealed higher values in male participants at the parietal lobes. Thus, the process of recognizing and differentiating the stimulus among men was faster, with more powerful focus and attention on the operative memory. In the left hemisphere of men and women the smaller latent periods of P3component (in the central lobe) and amplitudes of N2 and P3 components were determined compared to the right hemisphere. Thus, the motor programs switching in the paradigm of the experiment occurred with the sequential activation of the left and contralateral right hemispheres.
Influence of zinc nanoaquacitrate on the immuno-physiological reactivity and productivity of the organism of rabbits
Authors: Boiko О. V. , Honchar О. F. , Lesyk Y. V. , Kovalchuk І. І. , Gutyj B. V. 
Published: May 2020

Zinc is necessary for maintaining the immune status, and its deficiency in the organisms of animals is usually accompanied by the condition of immune deficiency. The objective of the study was determining the effect of different amounts of zinc on the immune-biological reactivity and productivity of the organism of rabbits after their weaning on the 50th and 86th days of life. For the study, rabbits with the weight of 1.2–1.4 kg were selected and divided into four groups (control and three experimental). The rabbits of the control group were fed with unlimited balanced granulated compound feed, and had free access to water. The animals of the I, II and III experimental groups were watered with zinc nanoaquacitrate in the amounts of 0.25, 0.50 and 0.75 mg of Zn/kg of body weight. Compared with the control group, watering of the animals of the experimental groups with zinc nanoaquacitrate to a greater extent affected the content of phagocytic activity, lysozymic and bactericidal activities of the blood serum as integral factors of non-specific cellular and humoral resistance of the organism, which manifested in the increase in their content in blood on the 12th, 24th and 36th days of the experiment. Use of organic supplement in the diet of rabbits had a stimula­ting effect on the functioning of the immune system of their organism, which was seen in the higher content of total immunoglobulins, sialic acids and ceruloplasmin in the blood of animals watered with zinc nanoaquacitrate in the quantities of 0.50 and 0.75 mg of Zn/kg of body weight on the 24th and 36th days of the experiment. Use of organic compound of zinc in the diet caused high parameters of growth of the organism of rabbits during the period of 36 days, which manifested in the highest parameters of average-day increments and body weight on the 86th day of the life of the rabbits from the III experimental group, which received zinc nanoaquacitrate in the amounts of 0.75 mg of Zn/kg of body weight compared with the control group. Watering rabbits with zinc nanoaquacitrate during the study was accompanied by probable changes in the number of erythrocytes, concentration of hemoglobin and erythrocyte indices, which could indicate a positive effect of the employed additives on the hematopoietic function of the rabbits’ organism. The data of the performed experiment suggest that watering with larger amounts of organic compound of zinc has a positive effect on the processes of formation of immuno-physiological reactivity of the rabbits’ organism and increase in their productivity. The practical purpose is the study of the impact of watering with zinc nanoaquacitrate on the immuno-biological reactivity of the organism of rabbit dams during the period of lactation.
Decreased carO gene expression and OXA-type carbapenemases among extensively drug-resistant Acinetobacter baumannii strains isolated from burn patients in Tehran, Iran
Authors: Abbasi Elham , Goudarzi Hossein , Hashemi Ali , Chirani Alireza Salimi , Ardebili Abdollah , Goudarzi Mehdi , Sharahi Javad Yasbolaghi , Davoudabadi Sara , Talebi Ghazaleh , Bostanghadiri Narjes 
Published: May 2020

AbstractA major challenge in the treatment of infections has been the rise of extensively drug resistance (XDR) and multidrug resistance (MDR) in Acinetobacter baumannii. The goals of this study were to determine the pattern of antimicrobial susceptibility, blaOXA and carO genes among burn-isolated A. baumannii strains. In this study, 100 A. baumannii strains were isolated from burn patients and their susceptibilities to different antibiotics were determined using disc diffusion testing and broth microdilution. Presence of carO gene and OXA-type carbapenemase genes was tested by PCR and sequencing. SDS-PAGE was done to survey CarO porin and the expression level of carO gene was evaluated by Real-Time PCR. A high rate of resistance to meropenem (98%), imipenem (98%) and doripenem (98%) was detected. All tested A. baumannii strains were susceptible to colistin. The results indicated that 84.9% were XDR and 97.9% of strains were MDR. In addition, all strains bore blaOXA-51 like and blaOXA-23 like and carO genes. Nonetheless, blaOXA-58 like and blaOXA-24 like genes were harbored by 0 percent and 76 percent of strains, respectively. The relative expression levels of the carO gene ranged from 0.06 to 35.01 fold lower than that of carbapenem-susceptible A. baumannii ATCC19606 and SDS – PAGE analysis of the outer membrane protein showed that all 100 isolates produced CarO. The results of current study revealed prevalence of blaOXA genes and changes in carO gene expression in carbapenem resistant A.baumannii.
Waterproof and breathable polyacrylonitrile/(polyurethane/fluorinated-silica) composite nanofiber membrane via side-by-side electrospinning
Authors: Yu Yunge , Zhang Fuli , Liu Yan , Zheng Yuansheng , Xin Binjie , Jiang Zhenlin , Peng Xiaoxiao , Jin Shixin 
Published: May 2020

Abstract
Komparasi Pemanfaatan Barang Dalam Hukum Kepabeanan Dan Hukum Ekonomi Syariah
Authors: Liswardi Liswardi 
Published: May 2020

Berdasarkan Undang-Undang kepabeanan No 10 tahun 1995 perubahan batas Undang-Undang no 17 tahun 2006 tentang kepabeanan, kemudian dalam Undang-Undang tersebut penindakan terhadap barang ilegal yang disita negara adalah dimusnahkan, maka dalam hal ini penulis tertarik untuk mengkaji kemanfaatan barang ilegal dalam hukum kepabenan dan hukum ekonomis islam yang dimusnahkan oleh negara. Tujuan penelitian ini adalah untuk menganalisis kemanfaatan barang ilegal yang dimusnahkan oleh negara berdasarkan Undang-Undang No 10 tahun 1995 atas perubahan Undang-Undang No 17 tahun 2006 tentang kepabeanan. Metode penelitian dalam penelitian ini adalah menggunakan metode studi dokumen/pustaka (library research) Hasil penelitian Pemusnahan barang ilegal yang dilakukan oleh kepabeanan berdasarkan Undang-Undang No 10 tahun 1995 atas perubahan Undang-Undang No 17 tahun 2006 sudah tepat dan Dilihat dari segi komparasi hukum kepabeanan dan ekonomi syariah barang ilegal adalah barang yang samasama melanggar dalam cara perolehannya.
Efficacy and Safety of Immune Checkpoint Inhibitors in Patients with Microsatellite Instability-High End-Stage Cancers and Poor Performance Status Related to High Disease Burden
Authors: Pietrantonio Filippo , Loupakis Fotios , Randon Giovanni , Raimondi Alessandra , Salati Massimiliano , Trapani Dario , Pagani Filippo , Depetris Ilaria , Maddalena Giulia , Morano Federica , Corallo Salvatore , Prisciandaro Michele , Corti Francesca , Guarini Vincenzo , Bocconi Alessandro , Marra Antonio , Belli Carmen , Spallanzani Andrea , Fassan Matteo , Lonardi Sara , Curigliano Giuseppe , Fucà Giovanni , Di Bartolomeo Maria , de Braud Filippo 
Published: May 2020

Abstract

Background
Few real-world series on the efficacy and safety of anti-programmed cell death protein-1(PD-1)/programmed death ligand-1(PD-L1)–based therapy are available in molecularly unselected patients with poor performance status (PS) and specific types of advanced cancers, because such populations are typically excluded from clinical trials due to poor life expectancy and risk of toxicity.

Materials and Methods
This multicenter retrospective case series included patients with microsatellite instability (MSI)-high metastatic cancers with Eastern Cooperative Oncology Group (ECOG) PS of 2 or 3 not related to comorbidities receiving anti-PD-1 with or without anti-CTLA-4 therapy after failure of at least one prior treatment line.

Results
We included 27 patients with six diverse tumor types: colorectal (n = 18), gastric (n = 5), biliary tract, pancreatic, small bowel, and endometrial cancers (n = 1 each). Baseline ECOG PS was 2 (74%) or 3 (26%). Overall response rate was 33%, with six partial and three complete responses. Median time to response was 3.1, months and median duration of response was 16.9 months. Median progression-free survival was 3.4 months (95% CI: 2.3 to not evaluable), and 18-month overall survival was 50.8% (95% confidence interval, 32.7–78.8). Baseline variables were not associated with survival outcomes. ECOG PS 1 was reached by 52% of patients in a median time of 6 weeks, and ECOG PS 0 was reached by 30% of patients in a median time of 10 weeks.

Conclusion
In a high proportion of patients with MSI-high cancers and poor performance status related to end-stage disease, salvage immunotherapy can induce potentially long-lasting “Lazarus responses”. Immunotherapy decisions near the end-of-life should be carefully integrated with predictive biomarkers and with palliative care measures in the real-world setting.

Implications for Practice
In this retrospective cohort study of 27 pretreated patients with microsatellite instability (MSI)-high cancers and Eastern Cooperative Oncology Group performance status of 2 or 3 not related to comorbidities, PD-1/PD-L1-based therapy induced a RECIST response in 33% of patients, with a median duration of 16.9 months, and an improvement of performance status in 52% of patients. MSI-high status can be used in clinical practice as a tumor-agnostic predictive biomarker to select critically ill patients with end-stage cancers for salvage immunotherapy.
Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2
Authors: Farkash Evan A. , Wilson Allecia M. , Jentzen Jeffrey M. 
Published: May 2020

Significance Statement
The cause of kidney injury in COVID-19 is unclear. In an autopsy study of a single patient with COVID-19 and acute oliguric renal failure, the authors identified intracellular viral arrays within proximal tubular epithelial cells by electron microscopy, consistent with direct infection of the kidney by SARS-CoV-2. They also found ultrastructural features similar to those described in reports of kidney cell lines infected with the related SARS-CoV-1 virus. Virally infected tubular cells showed isometric vacuolization on light microscopy. These findings provide confirmatory evidence of direct kidney infection by SARS-CoV-2 in a patient. However, this work does not exclude other causes of kidney injury, and additional study is needed to determine the frequency and clinical significance of direct kidney infection on renal failure in COVID-19.

Background
A significant fraction of patients with coronavirus disease 2019 (COVID-19) display abnormalities in renal function. Retrospective studies of patients hospitalized with COVID-19 in Wuhan, China, report an incidence of 3%–7% progressing to ARF, a marker of poor prognosis. The cause of the renal failure in COVID-19 is unknown, but one hypothesized mechanism is direct renal infection by the causative virus, SARS-CoV-2.

Methods
We performed an autopsy on a single patient who died of COVID-19 after open repair of an aortic dissection, complicated by hypoxic respiratory failure and oliguric renal failure. We used light and electron microscopy to examine renal tissue for evidence of SARS-CoV-2 within renal cells.

Results
Light microscopy of proximal tubules showed geographic isometric vacuolization, corresponding to a focus of tubules with abundant intracellular viral arrays. Individual viruses averaged 76 µm in diameter and had an envelope studded with crown-like, electron-dense spikes. Vacuoles contained double-membrane vesicles suggestive of partially assembled virus.

Conclusions
The presence of viral particles in the renal tubular epithelium that were morphologically identical to SARS-CoV-2, and with viral arrays and other features of virus assembly, provide evidence of a productive direct infection of the kidney by SARS-CoV-2. This finding offers confirmatory evidence that direct renal infection occurs in the setting of AKI in COVID-19. However, the frequency and clinical significance of direct infection in COVID-19 is unclear. Tubular isometric vacuolization observed with light microscopy, which correlates with double-membrane vesicles containing vacuoles observed with electronic microscopy, may be a useful histologic marker for active SARS-CoV-2 infection in kidney biopsy or autopsy specimens.
Assessment of the Results of Blood Cultures Taken in the Pediatric Clinic of a Training and Research Hospital in Mogadishu, Somalia
Authors: UĞUR Cüneyt 
Published: May 2020

Aim: The aim of this study is to determine the distribution of microorganisms isolated in blood culture and their antibiotic susceptibility retrospectively.Materials and Methods: This study was conducted at the Mogadishu Somalia Türkiye Recep Tayyip Erdogan Training and Research Hospital. A total of 76 patients who were hospitalized to the fpediatric clinic between the years of 2016 and 2018, who had significant reproduction in their culture tests and whose samples was performed antibiogram test were included. Demographic datas, microorganism strains and antibiogram results of these patients were recorded.Results: The subjects of this study were 37 females (48.7%) and 39 males (51.3%). The mean age of the subjects was 4.68 ± 4.74 (1 month-18 years) years. 57 (75%) of the reproduced microorganisms were Gram-positive bacteria, and 19 (25%) were Gram-negative bacteria. The most commonly isolated bacteria was coagulase-negative staphylococci (CoNS) by 36.8%. It was followed by Staphylococcus aureus (S. aureus) by 19.7%. The most commonly isolated Gram-negative bacteria was Escherichia coli (E. coli) by 6.6%. The antibiotic resistance of CoNS was highest against penicillin G by 85.7%, ampicillin-sulbactam (SAM) by 78.6% and trimethoprim sulfamethoxazole (TMP-SMX) by 75%. The antibiotic resistance of S. aureus was also highest against penicillin G (86.7%), SAM (80%) and TMP-SMX (73.3%).Conclusion: İt is necessary that conducting studies on this subject as periodic. In this way, it was concluded that morbidity and mortality may be reduced and development of antibiotic resistance may be prevented.
Joint Inversion of High-Frequency Receiver Functions and Surface-Wave Dispersion: Case Study in the Parnaíba Basin of Northeast Brazil
Authors: Victor Thayane , Julià Jordi , White Nicholas J. , Rodríguez-Tribaldos Verónica 
Published: May 2020

ABSTRACTWe assess the performance of the joint inversion of receiver functions (RF) and surface-wave dispersion in the characterization of the sedimentary package comprising the Parnaíba basin. This procedure is routinely utilized in passive-source crustal studies to retrieve S-wave velocity variations with depth, and has seldom been used with higher-frequency datasets to investigate fine sedimentary structure. The Parnaíba basin is a Paleozoic cratonic basin composed of five supersequences, accumulating ∼3.5  km of sedimentary rocks interbedded by Late Cretaceous diabase sills. The dataset used for this research was acquired between 2015 and 2017 through deployment of 10 short-period and one broadband seismic stations distributed along an approximately 100-kilometer-long linear array in the center of the basin. The deployment was carried out under the Parnaíba Basin Analysis Project, a multi-institutional and multidisciplinary effort funded by BP Energy do Brasil. High-frequency RFs (f&lt;4.8  Hz) were calculated from deconvolution of teleseismic P waveforms (30°&lt;Δ&lt;90°) after rotation into the great-circle path, whereas high-frequency dispersion curves (0.25–2 Hz) were obtained through multiple filter analysis of empirical Green’s functions developed from cross-correlation (ZZ component) and stacking (six months) of time–frequency-normalized ambient seismic noise recordings. S-wave velocity–depth profiles down to ∼5  km depth were developed through an iterative, linearized joint inversion approach. Comparison to independent active-source seismic profiles overlapping with our passive-source seismic line reveals the inverted velocity models successfully retrieve sedimentary thickness (top of the Cambrian), sedimentary velocity structure, and depth to the Cenozoic sedimentary sequence. In addition, high-velocity zones at depths ranging from 1.5 to 2.5 km are observed in the inverted velocity–depth profiles, which are interpreted as due to the Late Cretaceous sills interbedding the basin’s sedimentary rocks. The relative low cost of our approach makes it ideal for basic characterization of relatively unknown sedimentary basins.