bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene Therapy for Prostate Cancer: A Review
Authors: Talkar Swapnil S. , Patravale Vandana B. 
Published: May 2020

Background:
According to the American Cancer Society, prostate cancer ranks second in
terms of mortality and is a front-runner of newly detected cases. Conventional therapies neither
eradicated cancer nor increased the life expectancy of patients obviating the need for less toxic as well
as efficient therapies to treat cancer. Gene therapy alone, or in combination with conventional therapies,
possesses a strong potential to combat cancer.

Methods:
This review encompasses a brief note on the etiology and conventional therapy of prostate
cancer with an emphasis on gene therapy and its suitability for the treatment of prostate cancer.

Results:
A comprehensive range of gene therapy approaches have been successfully explored for prostate
cancer treatment in animal models and this has been well translated into early clinical trials. We
have also discussed in brief about specific therapeutic genes and suitable vector systems for gene therapy
in prostate cancer.

Conclusions:
Based on the results of these clinical trials, the application of gene therapy in prostate
cancer therapeutics can be satisfactorily established.
Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era
Authors: Lassandro Giuseppe , Palladino Valentina , Vecchio Giovanni C.D. , Palmieri Viviana V. , Corallo Paola C. , Faienza Maria F. , Giordano Paola 
Published: May 2020

Background and Objective:
Immune thrombocytopenia (ITP) is a common bleeding disorder
in childhood. The management of ITP in children is controversial, requiring personalized assessment
of patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag
and romiplostim, have been shown to be safe and effective for the treatment of pediatric ITP. The aim
of our research is to define the role of thrombopoietin receptor agonists in the management of pediatric
ITP.

Methods:
This review focuses on the use of TPO-RAs in pediatric ITP, in randomized trials and in
clinical routine, highlighting their key role in the management of the disease.

Results:
Eltrombopag and romiplostim appear effective treatment options for children with ITP. Several
clinical studies have assessed that the use of TPO-RAs increases platelet count, decreases bleeding
symptoms and improves health-related quality of life. Moreover, TPO-RAs are well tolerated with
minor side effects.

Conclusion:
Although long term efficacy and safety of TPO-RAs still require further investigations,
their use is gradually expanding in the clinical practice of children with ITP.
The Security Implications of Brexit
Authors: CASIS  
Published: May 2020

On February 20th, 2020, the Canadian Association for Security and Intelligence Studies (CASIS) Vancouver hosted its second roundtable in 2020 in partnership with the Vancouver Branch of the Canadian International Council (CIC), titled: The Security Implications of Brexit. This presentation featured British Consul General Nicole Davison as speaker, and a case study focusing on the potential implications of the “Wexit” separatist movement on the West Coast of Canada.
La energía distribuida como modelo post-fósil en Argentina
Authors: Kazimierski Martín 
Published: May 2020

En Argentina, la instalación de grandes parques solares y eólicos ha incrementado la participación de la energía renovable en la matriz energética, contribuyendo a las metas de diversificación y desfosilización nacional, aunque sin alterar las estructuras dominantes del sistema tradicional. Este trabajo sostiene que es posible pensar la penetración de estas energías como disparadores de nuevas experiencias público-ciudadanas basadas en la gestión local. A partir del análisis de tres elementos clave: empresas públicas, cooperativas y ciudadanos, el trabajo explora la potencialidad de la generación distribuida para traccionar una verdadera transición energética, hacia un modelo más descentralizado, desconcentrado y democrático.
The Imperfection in a Firm’s Knowledge of the Transformation Process Among Interlinked Internal Networks: The Defect Case
Authors: Kuntadi Cris , Boeditjahjono Prasetyo Boeditjahjono , Permatasari Yuli , Candrawati Meylia 
Published: May 2020

This study, firstly, identifies and analyzes the supply chain management of Aseli Dagadu Djokdja, Co., Ltd., (here-after ADD) which has a problem. Secondly, this study pinpoints what causes the problem in ADD’s supply-chain management (SCM). Thirdly, it investigates ADD’s knowledge of the transformation process, since it was not conducted properly. This research chose to use an exploratory case study with an in-depth interview to collect the data. This article questions all the CEOs and observes all stages of activity accompanied by their information, resources, and financial flows. The interviewer applies angulations to two or more of the subjects. This study takes note that ADD’s knowledge of the transformation process is imperfect; this weakness is at the top managerial level. The problem is also found when oral explanations do not follow the transfer of documents among the divisions and staff. It means that information asymmetry takes place. This study, which is designed with SNT and a comprehensive knowledge of the transformation process, has several biases. The first one is the inference validity bias. Secondly, it did not investigate how ADD’s management faces industrial competitiveness. Finally, this research could not capture what the staff at ADD transforms their knowledge into.
Short Film of Adolescent Reproductive Health Based on Friendly of Local Wisdom for Junior High School in Bondowoso
Authors: Susanto Tantut , Nur Kholid Rosyidi Muhammad , Astuti Soekma Yeni 
Published: May 2020

Background: The lack of information and low knowledge for adolescent reproductive health (ARH) have an impact on junior high school (JHS) students during puberty to develop unhealthy reproductive behaviors, such as dating and consumption of pornography through online media. Meanwhile, there are lack of facilities and infrastructure to accommodate the interests and talents of students that are friendly with local wisdom. Therefore, there is needed a partneships program between schools and university to improve student creativity for coaching ARH through empowerment of school environment. Furhermore, the aim of community egagement is to make a short film “healthy ARH” that is friendly to local wisdom to improve life skills of ARH.Method:The crativity of short movie program “healthy ARH” for local wisdom-friendly was conducted for 6 months at JHS 2 and JHS 3 Tamanan, Bondowoso. Among 36 students, 34 parents, and 6 teachers were participated in this program. Student creativity for making a short film was facilitated for promoting and education of ARH. This activities is an independent program from, by, and for students and teachers which are friendly with local wisdom. The series of activities consisted of community school consultations, training for made a short film, education and training for ARH, and monitoring and evaluation of program. Program measurements for students were performed through quantitatively measured for analyzed the differences of knowledge, attitudes, and behavior of ARH, as well as knowledge of HIV at the beginning of month 1, month 3, and month 6 using Chi square test. Whereas the qualitative evaluation was perforemed through focus group discussions (FGD) regarding the perceptions of students and teachers used a short film as ARH promotion media at the end of the program.Hasil:Among 36 students who took part in this program, there were significant differences for ARH of students before and after participating in the “healthy ARH” through short film based on local wisdom-friendly, both in terms of knowledge(X2= 33.6; p<0.001), attitudes(X2= 16.2; p=0.001), behavior(X2= 24.3; p<0.001), andknowledge ofHIV (X2= 11.9;p=0.008). Based on the FGD, the teachers were feel confident for conducting peer counselors using short film education media. These film was easier to educate the student regarding the values and norms of school environment. Meanwhile, students feel comfortable learning ARH from a short film and their interests and talent are facilitated by short film creativity.Kesimpulan:Ashort film “healthy ARH” based local wisdom-friendly program is able to improve the knowledge, attitudes and behavior of ARH, as well as the students' HIV knowledge. This program could be used as a medium for ARH education in schools by integrating with the school health program to improve life skills of ARH.
Developing a Prosthesis Design using A Gearbox to Replicate the Human Hand Mechanism
Authors: Jaber Haneen Mahdi , -Sattar Muhammed Abdul , Abd al-Sahib Nabel Kadhim 
Published: May 2020

Prosthetic is an artificial tool that replaces a member of the human frame that is absent because of ailment, damage, or distortion. The current research activities in Iraq draw interest to the upper limb discipline because of the growth in the number of amputees. Thus, it becomes necessary to increase researches in this subject to help in reducing the struggling patients. This paper describes the design and development of a prosthesis for people able and wear them from persons who have amputation in the hands. This design is composed of a hand with five fingers moving by means of a gearbox ism mechanism. The design of this artificial hand has 5 degrees of freedom. This artificial hand works based on the principle of under actuated system. The used motor is 6V Polulu high-power carbon brush micro metal gearmotor with gear ratio equal to 50:1. The motor was chosen due to its compactness and cheapness. The hand manufacturing process was done using a 3D printer and using polylactic acid material. Numbers of experiments were accomplished using the designed hand for gripping objects. Initially, the electromyography signal (EMG) was recorded when the muscle contracted in one second, two seconds, three seconds. The synthetic hand was able to produce a range of gestures and grasping for objects.
Permeable Reactive Barrier of Coated Sand by Iron Oxide for Treatment of Groundwater Contaminated with Cadmium and Copper Ions
Authors: Abdul-Kareem Mohammed B. , Faisal Ayad A.H. 
Published: May 2020

In this research, coated sand iron-oxide (CSIO) has been used as a permeable reactive barrier (PRB) for removal of cadmium and copper ions from the contaminated groundwater. The prepared material has been manufactured by precipitation of nano-particles based this oxide type on the sand surfaces by impregnation process. Therefore, this technique can be considered the main objective of the present study. The description of sorption data for sorbate-sorbent under consideration by the Langmuir isotherm model was more valuable than the Freundlich model. The maximum adsorption capacity of CSIO reaches 1.9181 and 7.6425 mg/g for cadmium and copper respectively. COMSOL Multiphysics Version release 3.5 has a good ability in the simulation and prediction of the cadmium and copper transport through one-dimensional CSIO-PRB. The outcome of this investigation prove that the manufactured CSIO has significant capability in the delay of contaminants the migration through barrier packed with this material. The root means squared errors between predicted and measured data were not exceeded the 0.121; so, this means that there a good agreement between these data
Teaching Biochemistry and Molecular Biology with Virtual Reality — Lesson Creation and Student Response
Authors: Coan Heather , Goehle Geoff , Youker Robert 
Published: May 2020

The commercialization of Virtual Reality (VR) hardware has enabled the use of VR as an educational tool. We describe how a VR platform was used to create molecular visualizations using standard PDB files with the purpose of delivering biochemistry and cellular biology lessons for undergraduates. Specifically, we describe two new software modules, one for rendering molecules generated from PDB files and one for creating interactive lectures. These modules were used to create two VR labs, one on DNA and collagen and the other on hemoglobin. We then describe how these labs were delivered, along with surveys and quizzes, to over 100 students in undergraduate biology courses. Student response to the labs are found to be extremely positive and the labs themselves are found to satisfy their educational objectives.
Why Does Digital Learning Matter? Digital Competencies, Social Justice and Critical Pedagogy in Initial Teacher Education
Authors: Coker Helen 
Published: May 2020

Digital tools and spaces are becoming prevalent in schools across the world requiring the development of digital skillsets for student-teachers. Digital technology, in enabling education to extend beyond the space and time boundaries of the conventional classroom (Seifert, T., Sheppard, B. Wakeham, M., 2015) , brings the digital landscape into the classroom and firmly into the frame of reference for those preparing student-teachers to enter the profession. For Initial Teacher Education (ITE) programmes which foreground social justice, the digital (technology which is linked to the internet) goes far beyond a skillset or a discrete subject. Engaging with digital learning encompasses the 21st century context - both local and global - in which student-teachers and their future pupils are situated.
Developing a critical pedagogic approach involves understanding the context in which one lives and enabling learners to challenge or change it (Freire, 1996) . For those working in ITE a postdigital lens provides a means to understand the context in which they are situated. Critical pedagogy enables student-teachers to understand that context and challenge the inequities which persist, preparing them not simply to navigate the digital landscape, but to engage with it critically. Reflecting on student-teacher learning this article explores the digital dimension, highlighting the importance of digital learning when engaging with critical pedagogy and social justice in ITE.
The Open Page Project
Authors: Stewart Bonnie 
Published: May 2020

This paper overviews an Open Educational Resource (OER) project aimed at developing digital literacies and open educational practice within a Faculty of Education. The project, titled (redacted), modelled and enacted three core digital learning principles – produsage, presence, and authentic audiences – for a broad audience of faculty and educators through the creation of videos and podcasts about educational technology tools.
Designed to enable Bachelor of Education students to work towards authentic assignments and open practice, while leading professional development for faculty and practicing teachers, (redacted) also developed student literacies in assessing and evaluating educational technology platforms. The project’s video and podcast outputs, showcased on a sub-page of the official Faculty of Education website, reflect intensive student research into the classroom uses, data implications, and differentiated learning possibilities of digital classroom tools.
The paper will introduce readers to the principles and pedagogy that shaped the design of (redacted), and examine its efforts to create a common conversation about digital learning between educators at all levels.
Punicalagin Alleviates Oxidative Stress and Pathological Changes in Brain of Mice-Fed High Fat, High Fructose Diet
Authors: Chandrasekaran Sathiya Priya  , Ramachandran Vidhya  , Kalivarathan Jagan  , Carani Venkatraman Anuradha  
Published: June 2020

The present study investigated to know whether the pomegranate polyphenol punicalagin (PU) can ameliorate oxidative stress and pathological alterations induced by a calorie rich diet comprised of fat and fructose. Male Swiss albino mice were fed normal pellet (Control) or high fat-high fructose diet (HFFD) for 60 days. PU (30 or 60 mg/kg bw) was administered orally for the last 15 days for both dietary groups. Measurement of TBARS, AOPP and FRAP in plasma, histopathology of liver and brain, assessment of oxidative damage in brain tissues, and blood brain barrier function were carried out. HFFD mice showed an increase in the levels of TBARS and AOPP, and a decline in FRAP. PU administration to HFFD mice reduced the levels of TBARS and AOPP and improved FRAP significantly. Histopathology results showed fatty changes and inflammatory infiltration in the liver of HFFD mice. Cortex and hippocampus of HFFD mice confirmed the presence of degenerating neurons with shrunken cytoplasm and pyknotic nuclei. PU treatment caused significant hepato and neuroprotective effects, and among the two doses the high dose of PU (60 mg/kg) showed more pronounced effects than the low dose (30 mg/kg). The immunohistochemical localization of the markers of oxidative damage to proteins (3-NT), lipids (4-HNE) and DNA (8-OHG) was increased in brain tissues of HFFD mice and upon PU administration (60 mg/kg) the levels of these oxidative stress markers were significantly decreased. Our findings clearly suggest that PU can modulate oxidative stress and could be a potential candidate for treating neurodegenerative processes associated with calorie excess.
PENERAPAN MODEL PEMBELAJARAN BERBASIS PROYEK (PROJECT BASED LEARNING) BERBANTUAN MEDIA GAMBAR UNTUK MENINGKATKAN KEMAMPUAN MENULIS CERITA FANTASI
Authors: Ginting Evi Susanti 
Published: May 2020

Penelitian ini bertujuan untuk meningkatkan keterampilan menulis cerita fantasi pada siswa kelas VII A 1 SMP Negeri 1 Singaraja melalui penerapan model pembelajaran berbasis proyek dengan bantuan media gambar. Penelitian ini adalah penelitian tindakan kelas yang dilaksanakan dalam dua siklus, yang terdiri dari rencana tindakan, pelaksanaan tindakan, observasi atau evaluasi dan refleksi. Subjek penelitian ini adalah siswa kelas VII A 1 SMP Negeri 1 Singaraja, berjumlah 30 orang dengan rincian 15 orang putra dan 15 orang putri. Data dianalisis menggunakan statistik deskriptif. Hasil analisis data rata-rata nilai keterampilan menulis cerita fantasi siklus I yaitu sebesar 72,46 dengan ketuntasan klasikal 43,33% dan rata-rata nilai keterampilan menulis teks tanggapan kritis pada siklus II yaitu sebesar 81, 76 dengan ketuntasan klasikal 86,67%. Dari data hasil belajar tersebut dapat dikatakan bahwa hasil belajar keterampilan menulis cerita fantasi pada siklus I ke siklus II mengalami peningkatan sebesar 9.3. Berdasarkan hasil analisis data dan pembahasan dapat disimpulkan bahwa hasil belajar keterampilan menulis cerita fantasi meningkat melalui penerapan model pembelajaran berbasis proyek berbantuan media gambar pada siswa kelas VII A 1 SMP Negeri 1 Singaraja.
Spatial Redistributions of Regional Economic Activity in Central Java (Direct Error Correction Model Causality Approach)
Authors: Panjawa Jihad Lukis , Samudro Bhimo Rizky 
Published: May 2020

This study analyzes spatial inequality through a causal relationship between inequality and economic growth within-recidency, between-recidency and overall in Central Java.The analytical tool used is the Direct Error Correction Model causality. This study shows that spatial concentrations throughout the observation period are quite high. In the 2001-2008 period there was an increasing tendency for spatialconcentration, reflecting the decline in the distribution of the Gross Regional Domestic Product (GRDP) share of districts and cities in Central Java. We also obtained similar findings in a number of regions both within and between-recidency. Post-2008, spatial concentration tends to decrease, indicating the distribution of the Gross Regional Domestic Product share. Other findings indicate a one-way relationship shown economic growth towards inequality. Another important contribution is that economic growth in inequality only occurs in the long term. Thus there has been convergence because of the increase ineconomic growth which is able to reduce inequality in all areas of Central Java, including within and between-recidency. This proves that during the implementation of regional autonomy there is a spread effect greater than the backwash effect in Central Java, including within and between-recidency.
Perceptions about Decision Making in Entrepreneurship from the Perspective of Community Participants in Accra, Ghana
Authors: Okyireh Marijke A. A. 
Published: May 2020

In this paper, we explored the experiences of twelve (12) community participants in the La Nkwantanang municipality (Accra) on when deciding for entrepreneurial activities. These participants were purposively selected from a previous study on entrepreneurial cognitions. The data was analysed using thematic analysis. The results of the study identified three major themes; perceptions attached to entrepreneurial activities; perceptions of past entrepreneurial experiences on decisions towards future venture creation; and potential challenges in decision-making for entrepreneurial businesses emerged from the narratives. Implications of the findings are discussed for theory and practice.
Financial Reporting Standards and Cost of Waters in Corporate Organization
Authors: Akande Adesola Adebayo 
Published: May 2020

This paper examined costs of waters and its disclosures propensity in financial statement of corporate organizations with a view to advocate for a suitable reporting standards globally. International Accounting Standard Board has not specifically announced or produced any financial reporting standard in support of reporting cost of waters despite the huge amount of monies that some corporate industries incurred on it. Both primary and secondary data were sourced from six breweries that uses water as one of their major raw materials and analyzed through descriptive statistics techniques of Analysis of Variance (ANOVA) and Simple Percentage Method (SPM). The result revealed that there were significant relationship between earnings and cost incurred on waters by some specialized industries like breweries, juice manufacturers and food processing companies in Nigeria and as such affects the earning potentials of the organization. On the average, water cost showed p-value of (0.04) > (0.05) level of significant in and p-value of (0.18) > (0.05) level of significant when reported differently from environmental costs. The result obtained from (80.1%) of the corporate affair section of six breweries and 65.7% professional accountants judgement from selected districts of the Institute of Chartered Accountants in Nigeria showed that there is urgent needs to provide for a separate standard of reporting such cost especially for specialized industries that uses water as their major input/raw material in their production. The study concludes that reporting cost of waters separately will project the principles of IFRS as prescribed by the board. Thus, the basic principles of human rights, cost standardization, environmental pollution protection and treatment-costs could be accounted for and reported in all the continent of the world. Based on this, the study recommends that accounting standards making bodies need to give cost of waters adequate consideration with allotment of appropriate standards for disclosure and reporting of costs of waters for all corporate organization world-wide to allign uniformity in financial reporting.