bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’élevage ovin Montmorillonnais partagé entre l’intensification et une voie plus extensive. Observations pour un débat
Authors: BENOIT M. , LAIGNEL G. , LIÉNARD G. 
Published: August 2020

Soumis à une forte concurrence de la part de la Grande-Bretagne et de l’Irlande, l’élevage ovin français connaît des conditions difficiles, marquées par une hausse continue des importations et une baisse des prix payés aux éleveurs (- 40 % entre 1980 et 1990). Les systèmes ovins les plus intensifs, très consommateurs d’intrants, peuvent être remis en cause, mais peuvent-ils être remplacés, et dans quelles conditions, par des systèmes moins intensifs ? L’étude concerne des exploitations ovines du Montmorillonnais (Vienne, France) ayant des effectifs relativement importants dans les conditions françaises (300 brebis et 430 agneaux par travailleur). Sept systèmes de production différents ont pu être identifiés. Deux situations stabilisées correspondant à des options d’intensification nettement différentes sont comparées. Les « Intensifs Réussis » pratiquent un système permettant de produire à la fois des cultures de vente et des ovins, grâce à un chargement des surfaces fourragères élevé (1,5 UGB/ha) et l’engraissement des 2/3 des agneaux en bergerie, l’ensemble entraînant une forte consommation d’engrais (110 unités de N + P + K/ha) et de concentrés (190 kg/brebis). Les « Herbagers Autonomes » ont opté pour un système davantage basé sur l’herbe (les 3/4 des agneaux sont mis à l’herbe) avec un chargement plus faible (1 UGB/ha) et une plus faible consommation d’intrants (58 NPK/ha et 107 kg de concentré/brebis) ; mais presque toute la surface est consacrée aux ovins et la production d’agneaux est légèrement plus importante (430 contre 410 par travailleur), avec moins de charges et moins de capital. Les résultats économiques obtenus sont équivalents en 1989 - 1990. Mais les élevages spécialisés moins intensifs, à condition d’être aussi bien gérés que les exploitations intensives, semblent mieux placés face aux aléas. Notamment le nombre d’agneaux produits par brebis doit être maintenu pour permettre l’obtention d’une marge supérieure grâce à la réduction des charges.
Mise à l’herbe des vaches laitières en zone de montagne : description des pratiques et liaison avec les performances laitières
Authors: DUBEUF B. , COULON J.B. , LANDAIS E. 
Published: August 2020

46 exploitations laitières des Alpes du Nord ont été classées à l’aide d’une typologie des systèmes de pratiques de mise à l’herbe. Les variations de la production laitière et de la composition chimique des laits de troupeau ont été observées dans chacun des types au cours de cette période. A la mise à l’herbe, la production et la composition du lait ont varié de manière importante, mais différente selon les types (- 0,5 à + 2,9 g/kg de taux protéique entre la 3e semaine avant la mise à l’herbe et la 3e semaine après ; - 1,6 à + 3,5 g/kg de taux butyreux ; + 1,6 à + 2,3 kg/j de lait). La maîtrise de l’alimentation hivernale est un facteur majeur des variations des taux protéiques et butyreux, alors que les pratiques de mise à l’herbe n’en modifient que faiblement l’amplitude. Les pratiques de gestion du système fourrager au printemps ont surtout une influence sur les ressources fourragères ultérieures. La maîtrise de l’alimentation des vaches laitières au pâturage est très liée à celle de l’alimentation hivernale.
Comportement de truies en groupe lors de la réalisation d’un apprentissage : utilisation d’un système alimentaire informatisé
Authors: VIEUILLE-THOMAS C. , SIGNORET J.P. 
Published: August 2020

Chez les truies gestantes, la conduite d’élevage, qui implique une alimentation individualisée, n’est plus limitée aux systèmes de contention depuis que les distributeurs informatisés se sont développés. Les femelles sont en liberté et alimentées à l’aide d’un appareil complexe délivrant des rations individuelles programmées. Ce type de système d’élevage répond ainsi aux exigences de la réglementation européenne récemment mise en place en matière de bien-être animal. Cependant, les animaux s’adaptent parfois difficilement à cette technique : les résultats obtenus sur 13 groupes de dix truies montrent que 55,4 % des femelles seulement apprennent spontanément l’utilisation de l’appareil en 24 heures. 16,2 % le font après avoir été séparées des premières, alors que 18,5 % ne réussissent à réaliser cet apprentissage qu’avec l’aide de l’éleveur qui les y attire par la distribution d’aliments. Enfin les 10 % restant demandent un apprentissage plus prolongé. Les différences observées dépendent de caractéristiques individuelles : les truies utilisant facilement l’appareil ont un profil comportemental opposé à celles qui posent des problèmes d’apprentissage. Ces dernières apparaissent comme des individus initiateurs de déplacements provoqués, peu explorateurs et non dominants en situation de compétition alimentaire. Les conditions d’apprentissage sont donc liées à des paramètres individuels difficilement modifiables par des techniques d’élevage. Un moyen de faciliter la tâche des éleveurs serait de familiariser les animaux au stade "cochette" à des dispositifs alimentaires proches de ce type de distributeur. Cette solution permettrait de réduire les réactions de crainte vis-à-vis de l’appareil et des bruits qui résultent de son utilisation.
Engraissement des vaches de réforme du troupeau allaitant en conditions de montagne
Authors: AGABRIEL J. , GAREL J.P. , LASSALAS J. , PETIT M. , Vantomme Y. , Maronne P. , Decuq F. 
Published: August 2020

Cent dix-huit vaches (86 de race Salers et 32 Limousines) ont été mises en expérience pendant 3 ans sur les domaines INRA de Marcenat (Cantal) et Laqueuille (Puy-de-Dôme) pour connaître les conditions de production de carcasses de vaches de réforme lorsque le régime alimentaire est à base de foin. Les foins, de valeur alimentaire très variable (DMO entre 58,5 et 64,0), ont été récoltés par beau temps, en demi-montagne (1000 m). C’est l’évolution de l’état d’engraissement moyen (note 3,5 - 4,0 sur 5) qui a déterminé la date d’abattage. Les vaches Salers d’état initial moyen (note 2 à 2,5) ont ainsi produit des carcasses de 350 kg environ, en 55-60 jours d’engraissement, en ingérant de 2,0 à 2,2 kg MS/100 kg poids vif/j. Il a fallu complémenter le fourrage avec un minimum de 5 kg/j de concentré pour obtenir des reprises de poids de l’ordre de 1000 - 1100 g/j et à l’abattage une proportion de dépôts adipeux de 16 à 17 % dans la masse corporelle, soit 19 à 20 % dans la carcasse (DACA). Lorsque les états d’engraissement initiaux sont plus faibles, allonger la durée d’engraissement ne modifie pas la croissance moyenne d’un lot, et permet d’obtenir des carcasses d’état et de poids comparables : il faut compter au minimum 12 jours supplémentaires d’engraissement pour un écart initial de 0,8 points de note. De même, diminuer l’apport de concentré à 3 kg/j allonge la durée d’engraissement de 10 jours environ et n’entraîne que peu de différence de poids et d’état final des carcasses. Dans les mêmes conditions d’engraissement, les carcasses des vaches Limousines sont d’un poids satisfaisant (330 kg) mais d’un état insuffisant (15 % DACA). Le faible niveau d’ingestion de foin (10 % de moins que les Salers) limite l’énergie disponible pour l’engraissement. Pour ce type de vaches il faut s’assurer d’une excellente qualité des fourrages de base, et distribuer plus de 50 % de la ration sous forme de concentré.
Nilai-nilai Pendidikan di dalam Ayat-ayat Seruan “ياأيهاالنّاس” (Wahai Manusia)
Authors: Rijal Muhammad Khairul , Nasir Muhammad 
Published: August 2020

Exploring, studying and practicing the values contained in the Qur'an is a must for every Muslim. Al-Qur'an is an ocean of knowledge that will never run out to continue to be studied and the values contained therein to be practiced in everyday life. In this study the researcher focused on the educational values contained in the verses starting with “ياأيهاالنّاس”, which if we discuss and study, we will find so many educational values contained in these verses including the values of faith, morals and good manners, as well as social values that are very important to be learned and practiced by Muslims to become pious individually and socially. The purpose of this study is to discuss more deeply the educational values contained in the verses starting with “ياأيهاالنّاس”. The research approach used is to collect verses that begin with the “ياأيهاالنّاس”, then draw conclusions about the educational values contained therein through literacy studies or literature by referring to classical and contemporary Tafsir books and books education.
Multiple population structure of the giant eel Anguilla marmorata in Thua Thien Hue, Vietnam base on COI sequences
Authors: Linh Nguyen Quang , Huyen Kieu Thi 
Published: August 2020

Abstract
The giant mottled eel Anguilla marmorata is a species of great economic, ecological, and conservative values in the Southeast Asian region. The research aims to conservation and evaluation of the genetic diversity of A. marmorata populations living in Thua Thien Hue, Vietnam. The sequencing of the barcode region of the cytochrome c oxidase subunit 1 gene was carried out for 48 individuals of A. marmorata , which were collected from five different ecosystem regions. The sequences were analyzed using various genetic, phylogenetic, and population analyses to assess their variability. A total of 20 polymorphic sites and 17 haplotypes were identified. Very low fixation (Fst = -0.073 – 0.003; < 0.05) was found for A. marmorata populations in the region. The populations showed signs of recent populations’ expansion, besides negative Tajima’s D test, Fu’s Fs, Fu and Li’s D* and F* test values. The genetic evolution of eel occurs in a randomized pattern over a large population, with the likelihood of rare alleles appearing in the population. In Thua Thien Hue (Viet Nam) territories, we indicated the five areas for conservation units with moderate eels’ populations’ diversity.
Control of malignant ascites using HIPEC in 2 patients with ovarian cancer: A case-report
Authors: Nikulin Vladislav , Abdullaev Amir , Davydov Mikhail , Rumyantsev Alexey , Kirsanov Vladislav , Bogush Elena , Tjulandin Sergei , Tyulyandina Alexandra 
Published: August 2020

Abstract
Objective: to demonstrate an efficacy of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in management of malignant ascites (MA) in patients with platinum-refractory ovarian cancer (OC).Background: MA in OC patients can dramatically affect quality of life. HIPEC is an investigational treatment modality that can be effective in MA setting but evidence-based data supporting this method are lacking. Cases presentation: 2 women 50-year-old, FIGO stage IV and 60-year-old, FIGO stage IIIC presented at our center, both had recurrent MA. Patients were treated with HIPEC after platinum-refractory recurrence. The first one had total control of MA with no evidence of disease at the time of last follow-up examination. The 2nd had 9 months of disease control – a relatively long time considering her MA recurrence rate.Conclusions: HIPEC can be successfully used for MA management in selected patients with epithelial OC refractory to standard chemotherapy, however more data are needed from randomized clinical trials.
Social Media Perceptions of Clubfoot Treatment: A Global Observational Study
Authors: Keil Evan J , Shaikh Hashim , Navarro Sergio M , Dube Andile , Yao Lilian E , Sheik-Ali Sharaf , Ncube Thando , Lavy Chris 
Published: August 2020

Abstract
Background: Clubfoot is a debilitating congenital anomaly that is often under treated in lower- and middle-income countries. There exists an active social media community with regards to clubfoot on both Instagram and Twitter. The purpose of this observational study was to investigate shared content related to clubfoot on social media. Methods: A search for public posts on social media regarding clubfoot was performed from October 31st, 2018 to October 31st, 2019. Three hashtags on Instagram and Twitter were analyzed: #clubfootsurgery, #clubfoot, and #clubfootmommas. Data was analyzed using Chi-squared tests with significance set to p<0.05.Results: Overall, 2050 posts with clubfoot-related hashtags were identified as publicly shared on these social media platforms over the 12-month period. 1992 met the inclusion criteria. Pictures consisted of 93.9% of posts which overwhelmingly had a positive tone, while only 16 posts were explicitly negative. On Instagram, personal accounts authored 95.5% of posts and on Twitter, organizations shared 99.4% of posts. Content related to active treatment was shared 32.7% of the time - of these posts, 94.8% showed Ponseti casting or Ponseti bracing. Chi-squared analysis was performed comparing Instagram with Twitter for media format, timing, tone, author, content, visibility, and topic reference. Statistically significant differences between the two (p<0.001) groups were found in each of these categories.Conclusions: Clubfoot treatment has a large social media presence with contributions from patients, treatment organizations, and physicians. Personal accounts on Instagram emphasize the patient experience, whereas organizations on Twitter focus primarily on education and increasing overall awareness.
Menarche and menopausal age changes over 40 years and its effective factors in women studied in Cohart Fasa population
Authors: Bazyar Neda , Jeihooni Ali Khani , moradi Zahra , Dehghan Azizollah , Farjam Mojtaba , Moradi Fatemeh 
Published: August 2020

Abstract
Background: Age at menarche and menopause is affected by various factors. A reduction has been observed in these ages over time. The present study aimed to determine the trend of changes in age at menarche and age at menopause among the women participating in Fasa Cohort Study over a 40-year period. Methods: This cross-sectional, descriptive-analytical study was conducted on 5545 women aged over 35 years in Fasa cohort population as a branch of the Persian cohort study. The participants were selected via census. The study data were obtained from the information registered in Fasa Cohort Center. Then, they were entered into the SPSS 22 software and were analyzed using descriptive statistics, chi-square test, correlation coefficient, and linear regression analysis. Results: The results showed that the mean age at menarche reduced from 14.66 to 13.40 years and the mean age at menopause decreased from 56.88 to 40.16 years over the 40-year period, and the reductions were statistically significant (p<0.001). Age at menarche was affected by body mass index and physical activity. Besides, age at menopause was affected by education level, marital status, diabetes, hypertension, cardiovascular diseases, cervical cancer, hysterectomy, and stillbirth (p<0.001). Conclusion: The results showed a decrease in age at menarche and age at menopause over the 40-year period.
rTMS modulates precuneus-hippocampal subregion circuit in subjective cognitive decline
Authors: Chen Jiu , Hu Guanjie , Xue Chen , Qi Wenzhang , Xu Wenwen , Chen Shanshan , Rao Jiang , Liu Wan , Zhang Fuquan , Zhang Xiangrong 
Published: August 2020

Abstract
Background: Hippocampal subregions (HIPsub) and their network connectivities are considered to be abnormal in subjective cognitive decline (SCD). This study aimed to identify whether repetitive transcranial magnetic stimulation (rTMS) could ameliorate the HIPsub network connectivity by modulating one node of HIPsub network in SCD subjects.Methods: In the first cohort (38 SCD and 55 healthy controls), we analyzed three HIPsub (i.e., hippocampal emotional, cognitive, and perceptual regions: HIPe, HIPc, and HIPp) functional connectivity to identify HIPsub network connectivity alterations that relate to SCD. And we further applied a support vector machine (SVM) approach using the alterations to identify how well this could distinguish SCD from CN. In the second cohort (13 SCD), rTMS with 5-day of once-daily for 2 weeks was used to modulate the altered HIPsub network connectivity in a sham-controlled design.Results: SCD subjects showed differently altered patterns of HIPsub network connectivity compared to controls. The SVM classifier showed that the abnormalities had a high power to discriminate SCD from CN, with an ACC of 86.0%, an AUC of 92.9%, 83.8% sensitivity, and 89.1% specificity. Restoration of HIPc connectivity with left parahippocampa gyrus and HIPp connectivity with left middle temporal gyrus corresponded to amelioration of episodic memory in SCD patients after 2 weeks of rTMS.Conclusion: rTMS can restore the posterior hippocampus connectivity by modulating the precuneus in SCD subjects. Correction of breakdown in HIPc and HIPp related to cognitive and perceptual processing can simultaneously ameliorate episodic memory in SCD subjects. Thus, these findings suggest that rTMS manipulation of precuneus-hippocampal circuit may prevent the disease progression by improving memory as the earliest at-risk state of AD in clinical trials.Trial registration: CCTR, ChiCTR2000034533. Registered 9 July 2020 - Retrospectively registered, http://www.chictr.org.cn
Exogenous melatonin enhances salt secretion from salt glands by upregulating the expression of ion transporter and vesicle transport genes in Limonium bicolor
Authors: Li Junpeng , Yuan Fang , Liu Yanlu , Zhang Mingjing , Liu Yun , Zhao Yang , Wang Baoshan , Chen Min 
Published: August 2020

Abstract
Background
Salt, a common environmental stress factor, inhibits plant growth and reduces yields. Melatonin is a pleiotropic molecule that regulates plant growth and can alleviate environmental stress in plants. All previous research on this topic has focused on the use of melatonin to improve the relatively low salt tolerance of glycophytes by promoting growth and enhancing antioxidant ability. It is unclear whether exogenous melatonin can increase the salt tolerance of halophytes, particularly recretohalophytes, by enhancing salt secretion from the salt glands.
Results
To examine the mechanisms of melatonin-mediated salt tolerance, we explored the effects of exogenous applications of melatonin on the secretion of salt from the salt glands of Limonium bicolor (a kind of recretohalophyte) seedlings and on the expression of associated genes. A pretreatment with 5 µM melatonin significantly improved the growth of L. bicolor seedlings under 300 mM NaCl. Furthermore, exogenous melatonin significantly increased the dry weight and endogenous melatonin content of L. bicolor. In addition, this treatment reduced the content of Na+ and Cl− in leaves, but increased the K+ content. Both the salt secretion rate of the salt glands and the expression level of genes encoding ion transporters (LbHTK1, LbSOS1, LbPMA, and LbNHX1) and vesicular transport proteins (LbVAMP721, LbVAP27, and LbVAMP12) were significantly increased by exogenous melatonin treatment. These results indicate that melatonin improves the salt tolerance of the recretohalophyte L. bicolor via the upregulation of salt secretion by the salt glands.
Conclusions
Our results showed that melatonin can upregulate the expression of genes encoding ion transporters and vesicle transport proteins to enhance salt secretion from the salt glands. Combining the results of the current study with previous research, we formulated a novel mechanism by which melatonin increases salt secretion in L. bicolor. Melatonin binds to an unknown receptor located at the PM, which activates the downstream signaling pathway, and then a NO or ROS signaling pathway. This in turn upregulates the expression of genes encoding ion transporters and vesicle transport proteins. The ion transporters transport ions (mainly Na+) into the salt glands, which are subsequently secreted through the participation of various ion transporters and transport vesicles to maintain ionic homeostasis in the cells and alleviate NaCl-induced growth inhibition.
Diagnostic value of real-time shear wave elastography in children with chronic kidney disease
Authors: Liu Qin , Zhengrong Wang 
Published: August 2020

Abstract
Objective To investigate the diagnostic value of real-time shear wave elastography (SWE) in children with chronic kidney disease (CKD).Methods Children with CKD diagnosed by the ultrasound-guided biopsy between January 2018 and May 2019 were enrolled as the case group. Age- and sex- matched healthy children were selected as the control group. The Young’s Modulus (YM) of the renal cortex was measured by SWE after the traditional ultrasound examination. Variance analysis was performed to compare the values of YM between the two groups. Receiver operating characteristic curve (ROC) analysis was used to compare the values of YM, and explore the cut-offs of the YM.Results In the case group (n=60, 45% male, mean age of 9.2 years), the kidney YM modulus on the left side (16.8±4.8 Kpa vs. 8.3±2.1 Kpa) and the right side (16.0±4.7 Kpa vs. 8.3±2.4 Kpa) were both higher than the control group (all P values<0.001). With the progress of CKD, the YM value of the left and right kidneys gradually increased. ROC analysis showed that when the left and right kidney YM value was 11.7 KPa and 11.0Kpa, the diagnostic sensitivity and specificity were the highest (left: respectively 93.3% and 95.0%; right: respectively 93.3 % and 91.7%).Conclusion The increase of YM in CKD is related to the progression of renal dysfunction which may provide a new method for early diagnosis of CKD, dynamic monitoring of disease progression, and evaluation of curative effect and prognosis.
Nodal-Induced L1CAM/CXCR4 Subpopulation Sustains Tumor Growth and Metastasis in Colorectal Cancer Derived Organoids.
Authors: Cave Donatella Delle , Momblona Xavier Hernando , Sevillano Marta , Minchiotti Gabriella , Lonardo Enza 
Published: August 2020

Abstract
BackgroundColorectal cancer (CRC) is currently the third leading cause for cancer-related mortality. Cancer stem cells have been implicated in colorectal tumor growth, but their specific role in tumor biology, including metastasis, is still uncertain.MethodsIncreased expression of L1CAM, CXCR4 and NODAL was identified in tumor section of patients with CRC and in Patients-derived-organoids (PDOs). The expression of L1CAM, CXCR4 and NODAL was evaluated using quantitative real-time PCR, western blotting, immunofluorescence, immunohistochemistry and flow cytometry. The effects of the L1CAM, CXCR4 and NODAL on tumor growth, proliferation, migration, invasion, colony-formation ability, metastasis and chemoresistance were investigated both in vitro and in vivo.Results We found that human colorectal cancer tissue contains cancer stem cells defined by L1CAMhigh/CXCR4high expression that is activated by Nodal in hypoxic microenvironment. This L1CAMhigh/CXCR4high population is tumorigenic, highly resistant to standard chemotherapy, and determines the metastatic phenotype of the individual tumor. Depletion of the L1CAMhigh/CXCR4high population drastically reduces the tumorigenic potential and the metastatic phenotype of colorectal tumors.ConclusionIn conclusion, we demonstrated that a subpopulation of migrating L1CAMhigh/CXCR4high is essential for tumor progression. Together, these findings suggest that strategies aimed at modulating the Nodal signaling could have important clinical applications to inhibit colorectal cancer-derived metastasis.