bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological distress, drug use, and internet use: the association with poor sleep quality in a sample of secondary school students
Authors: Olashore Anthony A. , Akanni Oluyemi O. , Ayilara Olaniyi O. 
Published: May 2020

Abstract
BackgroundSleep problems are common among children and adolescents. Sleep quality plays a significant role in adolescents’ mental health. The study aimed to determine the prevalence of poor sleep quality (PSQ) among secondary school students, identify sociodemographic factors associated with PSQ in this group, and to examine the independent associations of psychological distress, stimulant use and internet use with PSQ.MethodsData were collected from 420 secondary school students from four different schools who were selected using a mixture of convenience and random sampling. A set of questionnaires was administered to collect data, and it consisted of 5 sections measuring: the sociodemographic, drug use, psychological distress, internet use, and sleep qualityResultsA total of 378 questionnaires were analyzed. The prevalence of those with PSQ was 12.2%. A logistic regression model showed that anxiety (AOR=1.20, 95%CI:1.10-1.32), depression (AOR=1.12, 95%CI:1.00-1.25), and internet use (AOR=1.02, 95%CI:1.00-1.03) were significantly associated with PSQ.ConclusionsPSQ commonly exists among students and has a relationship with their psychological state and potentially addictive behavior, such as internet use. A bi-directional evaluation of PSQ as a cause and, or effect of psychological and addictive problems, was further recommended.
Nationwide population-based cohort study of adverse obstetric outcomes in pregnancies with myoma or following myomectomy: Retrospective cohort study
Authors: Lee Se Jin , Ko Hyun Sun , Na Sunghun , Bae Jin Young , Seong Won Joon , Kim Jong Woon , Shin Jaeeun , Cho Hae Joong , Choi Gyu Yeon , Kim Jinsil Kim , Cho Geum Joon , Park In Yang 
Published: May 2020

Abstract
Background Our objective was to evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy.Methods We analyzed the national health insurance database, which covers almost the entire Korean population, between 2004 and 2015. The risks of adverse pregnancy outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy, compared to those in women without a diagnosed myoma, were analyzed in multivariate logistic regression analysisResults During the study period, 38,402 women with diagnosed myoma(s), 9,890 women with a history of myomectomy, and 740,675 women without a diagnosed myoma gave birth. Women with a history of diagnosed myoma(s) and women with a history of myomectomy had significantly higher risks of cesarean section (aOR 1.13, 95% CI 1.1-1.16, p = 0.042; and aOR 7.46, 95% CI 6.97-7.98, p < 0.001, respectively) and placenta previa (aOR 1.41, 95% CI 1.29-1.54, p = 0.042; and aOR 1.58, 95% CI 1.35-1.83, p < 0.001, respectively), compared to women without a diagnosed myoma. And the risks of uterine rupture, preterm birth, and low birth weight were significantly higher in women with previous myomectomy but not in women with diagnosed myoma(s), compared to women without a diagnosed myoma (aOR 12.78, 95% CI 6.5-25.13, p < 0.001; aOR 1.64, 95% CI 1.47-1.84, p < 0.001; and aOR 1.53, 95% CI 1.39-1.68, p < 0.001, respectively). The incidence of uterine rupture was the highest at delivery within one year after myomectomy and decreased over time after myomectomy.Conclusions When a woman who might become pregnant later on is diagnosed with uterine myoma, she should be counseled about the risk of myoma(s) and myomectomy on obstetric complications, especially including the significant risk of uterine rupture in pregnancies following myomectomy.
Clinical Manifestation and Maternal Complications and Neonatal outcomes in Pregnant Women with COVID 19: An Update a Systematic Review and Meta-analysis
Authors: Soheili Marzieh , Moradi Ghobad , Baradaran Hamid Reza , Soheili Maryam , Moradi Yousef 
Published: May 2020

Abstract
Background Existing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with coronavirus infection. outbreaks suggest that pregnant women and their fetuses are particularly susceptible to poor outcomes. However, there is little known about pregnancy related complications and co-morbidity in this group of women. Therefore, this, systematic review and meta-analysis performed in order to find out whether COVID-19 may cause different manifestations and outcomes in antepartum and postpartum period or not.Methods We searched databases, including Medline (PubMed), Embase, Scopus, Web of sciences, Cochrane library, Ovid and CINHAL to retrieve all articles reporting the prevalence of maternal and neonatal complications, in addition clinical manifestations, in pregnant women with COVID 19 that published with English language from January to April 2020. Results 11 studies with total 177 pregnant women included in this systematic review.Results show that the pooled prevalence of neonatal mortality, lower birth weight, stillbirth, premature birth, and intrauterine fetal distress in women with COVID 19 were 4% (95% Cl: 1 - 9%), 21% (95% Cl: 11 – 31%), 2% (95% Cl: 1 - 6%), 28% (95% Cl: 12 - 44%), and 15% (95% Cl: 4 - 26%); respectively. Also the pooled prevalence of fever, cough, diarrhea and dyspnea were 56% (95% Cl: 30 - 83%), 30% (95% Cl: 21 - 39%), 9% (95% Cl: 2 - 16%), and 3% (95% Cl: 1 - 6%) in the pregnant women with COVID-19.Conclusion According to this systematic review and meta-analysis, the pregnant women with COVID-19 with or without pneumonia, are at a higher risk of pre-eclampsia, preterm birth, miscarriage and cesarean delivery. Furthermore, the risk of LBW and intrauterine fetal distress seems increased in neonates.
The Effect of Ethical Leadership on Subjective Wellbeing, Given the Moderator Job Satisfaction (A Case Study of Private Hospitals in Mashhad)
Authors: Kaffashpoor Azar , sadeghian samaneh 
Published: May 2020

Abstract
Background: The emerging ethical leadership, a novel approach in leadership perspective, has provided the ground for building and promoting individual and organizational effectiveness through prioritizing ethics in organization. The purpose of the study is survey of effect of Ethical Leadership on Subjective Wellbeing, Given the Moderator Job Satisfaction in Private Hospitals in Mashhad Methods: This research, employing a descriptive-correlational survey design, was conducted in 2015-2016 to examine the probable effect of ethical leadership on subjective wellbeing and job satisfaction (both as the outcome variable and the mediator) among the nurses of private hospitals in Mashhad, Iran. The statistical population included all nurses of private hospitals in Mashhad city (730 nurses, in total) from among whom following a simple randomized method, 166 nurses were selected as a sample of respondents. The data were collected with the adapted version of the questionnaire designed by Yang (2014) the validity and reliability of which were tested and confirmed. For data analysis, structural equation modeling (SEM) was used. Results: The results indicated a positive significant relationship between ethical leadership and job satisfaction. Ethical leadership only indirectly and through job satisfaction positively and significantly affected the subjective wellbeing of nurses. Conclusions: This suggests that an emphasis on ethics and ethically-oriented leaders in hospitals, aided by job satisfaction, can provide a positive climate which can lead to the subjective wellbeing of nurses.
Effect of Inflammatory Status on the Association Between Cardiovascular Health and Cognitive Function: A Cross-Sectional Study
Authors: Lee Ji Heon , Jeon Ye Jin , Kim Hyeon Chang , Jung Sun Jae 
Published: May 2020

Abstract
Background: Information related to the association between cardiovascular health (CVH) level and cognitive dysfunction in the Korean population is very limited. The objective of our study was to investigate the effect of inflammatory status on the association between CVH and cognition.Methods: Data were obtained from the baseline assessments of the Cardiovascular and Metabolic Diseases Etiology Research Center study. Participants who completed fasting serum analysis, questionnaires, and cognitive function tests were included in the analyses, whereas those with a history of autoimmune disease were excluded. Cardiovascular Health in Ambulatory Care Research Team health index metrics, including smoking, physical activity, healthy diet, obesity, history of hypertension, and history of diabetes, were used to assess CVH. Cognitive function was evaluated with the Korean version of the Mini-Mental State Estimation for Dementia Screening. Inflammatory status was assessed based on a high-sensitivity C-reactive protein (hs-CRP) test.Results: Among 2,622 total participants (mean age 57.2 years; 1,792 women [68.3%]), 342 (13%), 1,520 (58%), and 760 (29%) had poor, intermediate, or ideal CVH, respectively. Logistic regression analysis demonstrated that CVH was not significantly associated with cognitive function. We further investigated the association between each component of CVH and low cognitive function by determining the hs-CRP level. Results showed that the only component affecting the association was hypertension history in men.Conclusions: Our findings suggest that CVH is not significantly associated with cognitive function in the middle-aged Korean population. In addition, inflammatory status had no significant effect on the association, and the only CVH-related factor affecting the association was hypertension history.Trial registration: KCT0001038, Clinical Research Information Service (CRIS)
Variations In Trim5α and Cyclophilin A Genes Among HIV-1 Elite Controllers and Non Controllers in Uganda; A Laboratory-Based Cross-Sectional Study
Authors: Amanya Sharon Bright , Nyiro Brian , Waswa Francis , Obura Bonniface , Nakaziba Rebecca , Nabulime Eva , Katabazi Ashaba Fred , Nabatanzi Rose , Bayiyana Alice , Mbowa Gerald , Kayongo Alex , Wayengera Misaki , Sande Obondo J. 
Published: May 2020

Abstract
Background Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV capsid for proteosomal destruction. Cyclophilin A, an intracellular protein has also been reported to influence HIV infectivity in a cell-specific manner. Accordingly, variations in TRIM5α and Cyclophilin A genes have been documented to influence HIV-1 disease progression. However, these variations have not been documented among Elite controllers in Uganda and whether they play a role in viral suppression remains largely undocumented. Our study focused on identifying the variations in TRIM5α and Cyclophilin A genes among HIV-1 Elite controllers and non-controllers in Uganda.Results From the sequence analysis, the rs10838525 G > A mutation in exon 2 of TRIM5α was found only among elite controllers (30%) while the rs3824949 in the 5’UTR was seen among 25% of the non-controllers. In the Cyclophilin A promoter, rs6850 was seen among 62.5% of the non-controllers and only among 10% elite controllers. Furthermore, rs17860048 in the Cyclophillin A promoter was predominantly seen among elite controllers (30%) and 12.5% non-controllers. From gene expression analysis, we noted that the respective genes were generally elevated among elite controllers, however, this difference was not statistically significant (TRIM5α p = 0.6095; Cyclophilin A p = 0.6389).Conclusion Variations in TRIM5α and Cyclophillin A promoter may influence HIV viral suppression. The rs10838525 SNP in TRIM5α may contribute to viral suppression among HIV-1 elite controllers. The rs6850 in the cyclophillin A gene may be responsible for HIV-1 rapid progression among HIV-1 non-controllers. These SNPs should be investigated mechanistically to determine their precise role in HIV-1 viral suppression.
Overexpression of Astroglial Major Histocompatibility Complex Class I in the Medial Prefrontal Cortex Impairs Visual Discrimination Learning in Mice
Authors: Wulaer Bolati , Hada Kazuhiro , Sobue Akira , Itoh Norimichi , Nabeshima Toshitaka , Nagai Taku , yamada kiyofumi 
Published: May 2020

Abstract
Background Immune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are often associated with neuropsychiatric disorders. Neuronal MHC class I (MHCI), such as H-2D, regulate neurite outgrowth, the establishment and function of cortical connections, and activity-dependent refinement in mice. We previously established mice expressing MHCI specifically in astrocytes of the media prefrontal cortex (mPFC) using the adeno-associated virus (AAV) vector under the control of the glial fibrillary acidic protein (GFAP) promoter. Mice expressing the soluble form of H-2D (sH-2D) in the mPFC (sH-2D-expressing mice) showed abnormal behaviors, including social interaction deficits and cognitive dysfunctions. However, the pathophysiological significance of astroglial MHCI on higher brain functions remains unclear. Therefore, cognitive function in mice expressing sH-2D in astrocytes of the mPFC was tested using the visual discrimination (VD) task to assess the impact of the astrocyte pathology and resulting behavioral changes.Methods Three separate batches of mice were used in the present study. sH-2D-expressing mice were subjected to the VD and reversal learning tasks, morphological analyses, and pharmacological intervention using clozapine in the social interaction and novel object recognition tasks.Results In pretraining, the performance of sH-2D-expressing mice was normal in response phase sessions (stages 1–4), but impaired in the punish phase session (stage 5). The total numbers of sessions, trials, normal trials, and correction trials to reach the VD criterion were significantly higher in sH-2D-expressing mice than in control mice. A morphological study showed that dendritic complexity was significantly reduced in the dorsal striatum of sH-2D-expressing mice. A treatment with clozapine ameliorated decreased social behavior as well as impaired object recognition memory in sH-2D-expressing mice.Conclusion Collectively, the present results suggest that the overexpression of astroglial MHCI in the mPFC results in impaired VD learning, which may be accompanied by decreased dendritic complexity in the dorsal striatum and mPFC.
The Samuel F. B. Morse Statue in Central Park: Toward a Sustainable Regime of Science-Based Monuments Conservation
Authors: Basso Elena , Pozzi Federica , Reiley Matthew C. 
Published: May 2020

Abstract
Many of Central Park’s bronze statues were coated with lacquer as a protective measure between the late 1970s and early 1990s. In several cases, these coatings outlasted their performance life and were no longer adequately protecting the sculptures. In 2010, a cyclical campaign to remove and refurbish the coatings provided an opportunity to closely assess the condition of de-coated surfaces and to develop suitable, sustainable treatment approaches. The Samuel F. B. Morse statue, created in 1870 by Byron Pickett, commemorates the 19th -century painter and inventor known for the telegraphic code that bears his name. Initially, samples from this statue were collected on the field and analyzed with various techniques to characterize the degradation products that were heavily affecting its surface and the organic coatings used to protect the bronze. Various corrosion species, mainly sulfates and chlorides, were identified by X-ray powder diffraction, while pyrolysis – gas chromatography / mass spectrometry revealed that the organic coatings were based on mineral wax and acrylics. These results informed a decision to relocate the statue to a controlled workshop space to aid in the manipulation of the large figure and optimize cleaning by laser ablation. Treatment was monitored through three campaigns of analysis using portable X-ray fluorescence (pXRF) spectroscopy, performed on select locations, to characterize the extent of corrosion across the sculpture’s surface and monitor changes on the target areas throughout the cleaning. Following the initial phase of treatment, pXRF showed the substantial removal of iron- and lead-rich compounds from the brownish-toned coating and atmospheric pollution deposition. In the subsequent treatment phases, variations in the relative amounts of sulfates and chlorides were noted and further investigated through the examination of a cross section by means of scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDS). Based on the findings of iron-containing pigments in the organic coating, a decision to apply a new, similar, light brown-toned coating containing such coloring materials was made to achieve the desired visual nuance for the finish and provide sacrificial anodic protection for the bronze. Scientific analysis on the Morse statue has helped characterize its materials, methods of fabrication, and current conditions on a microscopic scale; in addition, it has guided the means and methodologies of treatment and relays essential information useful for future preservation.
Non-Invasive Measurement of Choroid Plexus Blood Flow with Arterial Spin Labeling
Authors: Zhao Li , Taso Manuel , Dai Weiying , Press Daniel Z. , Alsop David C. 
Published: May 2020

Abstract
Background The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance. Here, we sought to characterize the blood flow dynamics of the choroid plexus using arterial spin labeling (ASL) MRI to establish ASL as a non-invasive tool for choroid plexus function and disease studies.Methods Seven healthy volunteers were imaged on a 3T MR scanner. ASL images were acquired with 12 labeling durations and post labeling delays. Regions of the choroid plexus were manually segmented on high-resolution T1 weighted images. Choroid plexus perfusion was characterized with a dynamic ASL perfusion model. Cerebral gray matter perfusion was also quantified for comparison.Results Kinetics of the ASL signal were clearly different in the choroid plexus than in gray matter. The choroid plexus has a significantly longer T1 (2.33 ± 0.30 s vs. 1.85 ± 0.10 s, p < 0.02) and a trend of lower arterial transit time (1.24±0.20 s vs.1.31 ± 0.12 s) than the gray matter. Blood flow to the choroid plexus was measured to be 39.5 ± 10.1 ml/100 g/min and 0.80 ± 0.31 ml/min integrated over the posterior lateral ventricles in both hemispheres.Conclusions Our findings suggest that ASL can provide a clinically feasible option to quantify the dynamic characteristics of choroid plexus blood flow. It also provides useful reference values of the choroid plexus perfusion. The long T1 of the choroid plexus may suggest the transport of water from arterial blood to the CSF, potentially providing a method to quantify CSF generation.
Performance of the Parasympathetic Tone activity (PTA) index to predict mean arterial pressure variations in anaesthetized horses with different health conditions
Authors: Mansour Christelle , Mocci Rita , Santangelo Bruna , Chaaya Rana , Allaouchiche Bernard , Bonnet-Garin Jeanne-Marie , Boselli Emmanuel , Junot Stéphane A 
Published: May 2020

Abstract
Background
The parasympathetic tone activity (PTA) is an index based on heart rate variability recently developed in animals to assess their relative parasympathetic tone and their analgesia nociception balance. The present study aimed to evaluate the variation of PTA in anaesthetized horses according to haemodynamic status and health conditions and to determine the performance of dynamic variations of PTA (∆PTA) to predict mean arterial pressure (MAP) variations.
Results
Thirty-nine client-horses admitted to the Veterinary Campus of Lyon were anaesthetized for elective or emergency surgery and divided into “Colic” and “Elective” groups. During anaesthesia, dobutamine was administered as treatment of hypotension (MAP < 60 mmHg). No significant variation of PTA and MAP were detected at steady-state and following cutaneous incision. PTA increased before each hypotension (+ 15% in Elective and + 11.4% in Colic group), conversely, the administration of dobutamine was accompanied by a significant decrease in PTA (-12.7% in Elective and − 9% in Colic group). Horses of the Colic group had lower PTA values than those in Elective group, whereas MAP didn’t differ between groups. Globally, to predict a 10% increase in MAP, ΔPTA performance was associated with: AUC ROC [95% CI] = 0.77 [0.70 to 0.83] (p < 0.0001), with a sensitivity of 88.2% and a specificity of 57.7% for a threshold value of − 1%. Besides, to predict a 10% decrease in MAP, ΔPTA performance was associated with: AUC ROC [95% CI] = 0.80 [0.73 to 0.85] (p < 0.0001), with a sensitivity of 62.5% and a specificity of 94.6% for a threshold value of 25%.
Conclusions
The PTA index in anaesthetized horses appears to be influenced by the haemodynamic status and the health condition. The shift toward lower PTA values in colic horses may potentially reflect a sympathetic tone predominance. Of clinical significance, a PTA increase of > 25% in 1 min showed fair performance to predict a MAP decrease of > 10% within 5 min but a decrease in PTA was poorly specific to predict an increase in MAP. Even though these results require further evaluation, this index may thus help to predict potential autonomic dysfunctions in sick animals.
Identification of Protective Peptides of Fasciola Hepatica-Derived Cathepsin L1 (FhCL1) in Vaccinated Sheep by a Linear B-cell Epitope Mapping Approach
Authors: Perazzo Leandro Buffoni , Garza-Cuartero Laura , Pérez-Caballero Raúl , Zafra Rafael , Martínez-Moreno F. Javier , Molina-Hernández Verónica , Pérez José , Martínez-Moreno Álvaro , Mulcahy Grace 
Published: May 2020

Abstract
Background Fasciolosis is one of the most important parasitic diseases of livestock. The need for better control strategies gave rise to the identification of various vaccine candidates. The recombinant form of a member of the cysteine protease family, cathepsin L1 of Fasciola hepatica (FhCL1) has been a vaccine target for the past few decades since it has been shown to behave as an immunodominant antigen. However, when FhCL1 was used as vaccine, it has been observed to elicit significant protection in some trials, whereas no protection was provided in others.Methods In order to improve vaccine development strategy, we conducted a linear B-cell epitope mapping of FhCL1 in vaccinated-protected, vaccinated but not protected, and unvaccinated-infected sheep.Results Our study showed that the pattern and dynamic of peptide recognition varied noticeably between protected and non-protected animals, and that the regions 55–63 and 77–84, which are within the propeptide, and regions 102–114 and 265–273 of FhCL1 were specifically recognised only by vaccinated-protected animals with significant decrease in fluke burden. In addition, these animals also showed significant production of specific IgG2, whereas none was observed in non-protected and infected animals.Conclusions We have identified forty-two residues of FhCL1 that contributed to protective immunity against infection with F. hepatica in sheep. Our results provide indications in relation to key aspects of the immune response. Given the variable outcomes of vaccination trials conducted in ruminants to date, this study adds new insights to improve strategies of vaccine development.