bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of combined cryotherapy/compression versus cryotherapy following ACL reconstruction with regard to return-to-sports 3 months after surgery
Authors: Zantop Thore , Zantop Christian , Hönninger Anja , Hauner Dominik , Warminski Przemyslaw 
Published: May 2020

Aims and Objectives: Morbidity following ACL reconstruction may be a key factor to reduce muscular dysfunction and increase physical activity. While intra-operative factors have been the focus of standardization within the last years, strategies reducing the morbidity such as postoperative cryotherapy have been investigated less. Goal of this study was to compare subjective and objective patient outcomes following ACL reconstruction with combined compression and cryotherapy compared with traditional ice therapy alone. We hypothesized that ryotherapy/compression will show significantly better results three months after ACL reconstruction compared to cryotherapy alone. Materials and Methods: A total of 40 Patients undergoing ACL reconstruction are prospectively randomized to be treated with cryotherapy/compression device (GameReady, CA/USA, group 1) or a cryotherapy device (Aircast Cryocuff, DJO CA/USA, group 2). ACL reconstructions were performed by a single surgeon with semitendinosus graft and standardized rehabilitation protocol. Patients were instructed to use the ice therapy devices 4 times per day for 30min. Pain management directly postoperatively was analyzed as recorded during clinical records and VAS. Follow-up was performed at 12 weeks postoperatively using visual analog scale (VAS), Lysholm knee score, Short Form 36 (SF36), and Tegner acitiy score. Additionally, a functional “return-to-sports” analysis including isokinetic strength measurements (BTE-primus), proprioceptive tests (MTF tests) and a 3d-motion analysis (myomotion, Noraxon) during bilateral drop jumps and single leg hop tests was performed. Results: VAS and comparison of the administrated painkillers showed no significant differences between the two groups. Both groups used the cryotherapy/compression device and the cryotherapy device as determined by the study protocol. At 12 weeks, there was no significant difference between the two groups with regard to Lysholm score, Tegner score, and SF-36, however there was a trend towards better scores in group 1. The was a higher range of motion in group 1 compared to group 2. Functional analysis with isokinetic strength measurements, proprioceptive test and a 3d-motion analysis revealed better functional results in patients of the group cryotherapy/compression device compared to cryotherapy alone. Conclusion: This prospective analysis of 40 patients following semitendinosus ACL reconstruction with one single surgeon implicates that the use of a cryotherapy/compression device (GameReady) showed significantly better objective patient outcomes following ACL reconstruction compared to cryotherapy alone.
Prevalence, Development, and Factors Associated with Cyst Formation after Meniscal Repair with the All-Inside Suture Device
Authors: Zantop Thore , Hashimoto Yusuke , Nakamura Hiroaki 
Published: May 2020

Aims and Objectives: The aim of this study is to investigate the prevalence of cyst formation as a complication of all-inside meniscal suture device using magnetic resonance imaging (MRI) and analyze the risk factors. Materials and Methods: Of the patients who had undergone meniscal repair surgery 46 cases (46 knees) were selected to be in the case-control study. 51 menisci (34 medial menisci, 17 lateral menisci) of 46 cases were included to the study. Out of 51 menisci, 46 menisci combined anterior cruciate ligament (ACL) ruptures and had performed ACL reconstruction (ACLR). 5 cases (5 menisci) had been performed meniscal repair (MR). MRIs of the knee were performed 6, 12 and 24 months post-meniscal surgery. The MRIs were examined to detect the new development of cysts encasing the suture anchors and evaluate meniscal healing. Univariate and multivariate risk factor analyses was used to account for the suture technique (suture device alone versus suture device and inside-out suture repair), concurrent operation (MR alone versus MR with ACL reconstruction), patient gender, medial versus lateral menisci, number of device use, side-to-side difference of knee arthrometer, type of anchor (acetal resin versus PEEK material) and clinical scores (Lysholm score, Tegner activity scale, IKDC score). Results: MRI examinations revealed cyst formation in 15 of 51 menisci. 3 menisci were detected cyst formation at 6 months of surgery, 9 at 12 months and 3 at 24 months. Only 3 patients (6.5%) were symptomatic. Tecxhniques using suture device alone was more likely to develop cysts: odds ratio (OR) was 10.67 (95% confidence interval (CI) 1.25 to 91.41). Medial meniscus statistically tended to develop cyst compared with lateral meniscus and OR was 7.92 (95% confidence interval (CI) 1.23 to 51.07). Patients who have instability (side-to-side difference of knee arthrometer > 3mm) are more likely to develop cysts than that ofless than or equal to 3mm (p = 0.06). Conclusion: This study revealed the risk factors and prevalence rate for cyst formation after using the all-inside meniscal suture device. The prevalence rate of cyst formation around suture implant was 29%, however most cases didn’t have any symptoms. Suture device only and medial meniscus were significant risk factors for cyst formation. Knee instability was greater in the cyst developed menisci though it was not significant, which suggested that knee instability could affect cyst formation around suture anchors.
A Selective arthroplasty algorithm contributes to clinical outcome and patient satisfaction in patients with osteoarthritis of the knee
Authors: Holz Johannes , Schneider Stefan , Hansen-Algenstaedt Nils , Kaiser Rene , Ilg Ansgar 
Published: May 2020

Aims and Objectives: The purpose was to evaluate the clinical outcomes and patient satisfaction of patients with knee osteoarthritis treated within a selective arthroplasty algorithm, using focal metal implants (FMI), unicompartmental (UKA), patellofemoral (PFA), bicompartimental (BKA) and total knee arthroplasty (TKA) in a single center. Materials and Methods: This is a prospective study analyzing a consecutive series of 613 patients treated by two surgeons in a single center. In 283 men and 330 women either partial or total knee replacement were performed. Their mean age at surgery was 63±6,85 years and mean BMI 29,55±5,00 kg/m2. 357 UKA, 178 TKA, 30 PFA, 23 BKA and 25 FMI were performed. Implants were cemented or cementless (UKA) and made of cobalt chrome in partial knee and zirconium oxide in total knee replacement. Demographics and patient reported outcomes (VAS, KOOS, Oxford Knee Score (OKS) and Knee Society Score (KSS Expectations and satisfaction)) were collected preoperatively and 3,6 and 12 months postoperatively. A total of 442 of 457 eligible patients (Compliance = 96,7%) have thus far completed the 12 months follow-up time point. Results: All mean KOOS, OKS, KSS and VAS scores improved significantly 1 year after surgery (p<0.05). Mean preoperative aggregated KOOS improved from 49.8±13,3 to 74,8±16.9 in UKA, from 43,9±13,3 to 65,2±12,4 in PFA, from 46.6±13,1 to 73,8±14,4 in TKA, from 45,2±11,2 to 73,0±9,8 in BKA and 40.9 ± 23.0 to 63.2 in FMI (p<0.05). Mean preoperative aggregated OKS improved from 25,3±7,6 to 38,7±8,4 in UKA, from 22,9±7,6 to 33,3±8,6 in PFA, from 23.3±7.3 to 37,5±7.7 in TKA, from 22,0±7,5 to 39,0±4.0 in BKA and from 22.9 ± 10.0 to 33.4 ± 11.3 in FMI (p<0.05). The mean pain level VAS decreased from pre-treatment to 12 months after surgery in UKA from 5.6 to 1.6, in PFA from 6.2 to 2.8, in TKA from 6.2 to 1.7, in BKA from 6.8 to 1.6 and VAS 5.5 to 2.4. The Mean KSS Expectation/Satisfaction improved at 1 y FU in UKA in expectation 13.7 ± 1.6 and mean KSS satisfaction: 31.1 ± 8.4, in FMI in expectation: 13.5 ± 1.6 and mean KSS satisfaction 26.0 ± 11.4 , in TKA: expectation 13.5 ± 1.8 and mean KSS satisfaction 30.0 ± 7.1, in PFA: expectation 13.7 ± 1.7 and mean KSS satisfaction 26.4 ± 9.2 and BKA: expectation 13.6 ± 1.9 and mean KSS satisfaction 31.2 ± 4.2. Two patients (0.4%) underwent revision (at 3 month for inlay dislocation (UKA) and at 12 Month for desease progression (FMI)). Conclusion: This study shows excellent clinical results and patient satisfaction of patients treated within a selective arthroplasty algorithm. Adherence to strict indications for partial as well as for total knee replacement will lead to a comparable significant improvement of patient reported outcomes, patient satisfaction and a low revision rate one year postoperatively.
Posterior condylar offset ratio more precisely reconstructed with robotic arm-assisted total knee arthroplasty when compared to conventional manual technique
Authors: Tücking Lars-René , Savov Peter , Windhagen Henning , Ettinger Max 
Published: May 2020

Aims and Objectives: The use of robotic-arm assisted total knee arthroplasty promises more precision in TKA implant technique. Precise implantation is elemental in improving functional and radiological outcome after TKA. The posterior condylar offset ratio (PCOR) is one important radiological parameter in total knee arthroplasty (TKA). The PCOR correlates with the maximum range-of-motion of the knee. A decrease of PCOR in TKA could lead to early impingement of the tibial insert with a consecutive decreased flexion range of the knee. The primary objective of this study was to determine differences in PCOR reconstruction after TKA between manual and robotic arm-assisted TKA surgery. Materials and Methods: A total of 80 patients undergoing primary TKA performed by one single senior surgeon were included in this prospective study. Two groups (Robotic arm-assisted TKA group, manual TKA group, n=40 patients each) were compared on the basis of hip-knee-ankle angle (HKA), medial proximal tibial angle (mPTA), distal lateral femoral angle (dLFA) and PCOR. Weight-bearing full-leg a.p. radiographs, as well as lateral knee radiographs, were performed pre- and postoperatively. All surgeries were performed with one single posterior stabilized TKA prosthesis type. Statistics consisted of parametric t-testing with a level of significance of p<0.05. Results: Preoperative limb alignment, mPTA and dLFA did not differ in between groups (each p>0.05). Postoperative mean PCOR was larger in the robotic arm-assisted TKA group (0.51 ± 0.05 vs. manual TKA group 0.47 ± 0.05, p=0.006). The absolute mean difference of pre- and postoperative PCOR was higher in the manual TKA group when compared to the robotic arm-assisted TKA group (-0.059 vs. -0.017, p=0.001). Manual TKA group showed a mean relative deviation of 12,03% (± 9,1%) in pre- to postoperative PCOR, whereas a mean relative deviation of 3.9 % (± 4.5%) was found in the robotic arm-assisted TKA group. Conclusion: Robotic arm-assisted TKA showed higher precision regarding postoperative PCOR with lower absolute mean differences and less relative deviation in pre- and postoperative PCOR when compared to manual TKA. A precise reconstruction of PCOR correlates with a better functional outcome as shown in previous studies before.
A Closer Look is necessary: Traumatic luxation of the patella as a co-injury of an acl-rupture
Authors: Fehske Kai , Meffert Rainer , Eden Lars 
Published: May 2020

Aims and Objectives: The rupture of the acl is considered to be one of the most common knee injuries in sports traumatology. Many patients report that they felt the sensation of a luxated patella during their knee distorsion. In many cases patients patients with the suspicion of a traumatic patella luxation showed in the mri a complete rupture of the acl. Materials and Methods: We report about 10 patients consulting our department within the last year after a significant knee trauma. In the mri as well as during the arthroscopic evaluation they showed a complete rupture of the acl as well as the findings of a fresh, traumatic patella luxation. We evaluated and analysed the preoperative and intraoperative pictures (mri and arthrosopy). Results: All patients showed in the posttraumatic mri a complete rupture of the acl as well as an at least partial rupture of the mpfl and a rupture of the medial retinaculum. 4 patients showed a persistent subluxation of the patella, 8 patients showed also a rupture of the medial collateral ligament. During the operation we verified a significant instability of the patella in 8 patients so that a stabilization of the patella was performed (open medial stabilization or mpfl reconstruction) in the same operation the acl was reconstructed (semi-t). Eventhough the patients were treated with only one operation and the regaining of motion was prolonged compared with isolated acl-reconstruction, after 12 months postoperatively all patients had a satisfactory range of motion. Conclusion: The typical trauma mechanism for an acl rupture is a valgus position of the knee in combination with an external rotation of the tibia, which leads to an enlargement of the q-angle which is considered a predisposition for a patella luxation. If an acl rupture occurs, the patella can luxate within the same trauma. In the posttraumatic mri the rupture of the mpfl is often misinterpreted as a rupture of the medial collateral ligament, particularly if the patella is, as in most cases, in full reposition. Within an acl-rupture a luxation of the patella can occur simultaneously, leading to a significant instability which needs to be treated (medial stabilization or mpfl-reconstruction). Our data shows that a single stage treatment with acl-reconstruction and medial stabilization is technical practicable and mid-term investigation shows good clinical results without a higher risk of an arthrofibrosis.
Contamination of suture material and irrigation fluid over time during athroscopic reconstruction of the anterior cruciate ligament (primary and revision) and meniscus surgery
Authors: Bartek Benjamin , Garbe Anja , Schelberger Tarek Guy , Gwinner Clemens , Perka Carsten , Jung Tobias 
Published: May 2020

Aims and Objectives: During arthroscopic surgical procedures, some amount of irrigation fluid leaks from the surgical site and accumulates in the sterile reservoir. Whether these fluid collections show bacterial contamination over time in meniscus surgery and reconstruction of the anterior cruciate ligament (ACL) remains unclear. Materials and Methods: In this study, we include 200 patients. 100 patients undergoing ACL reconstruction and 100 patients undergoing meniscus surgery. We collected the samples of irrigation fluid before skin incision and every 15 minutes after the start of surgery. In addition, we evaluated the different types of suture material (Fast Fix and Outside-Inside threads in meniscus surgery and ACL reconstruction threads) for bacterial contamination. Results: At this point we evaluated samples of 152 patients (irrigation fluid of 152 patients, suture material of 100 patients). While no fluid sample showed contamination after 15 minutes, we overall detected bacterial contamination in 18,4%. Suture material was contaminated with bacteria in 28% of cases. Conclusion: At this point, fluid surgical drape reservoirs were abacterial during the first 15 minutes but showed marked bacterial contamination over time. During surgery, irrigation fluid reservoirs should not be withdrawn by suction after skin incision. The tendency of bacterial contamination of the suture material and irrigation fluid reservoir over time has to be further explored. The continues flush and perioperative use of antibiotics might take an important impact on the low number of joint infection compared to the contamination ratio of the suture material. In addition, the effect of saturating suture material with antibiotics needs to be explored.
Components of metabolic syndrome in patients with multiple myeloma and smoldering multiple myeloma
Authors: Markus Efrat , Trestman Svetlana , Cohen Yael , Angel Yoel , Sofer Yael , Mittelman Moshe , Avivi Irit , Stern Naftali , Izkhakov Elena 
Published: May 2020

Abstract
Background
The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among patients with smoldering MM (SMM).

Methods
Changes in various components of metabolic syndrome were investigated during the follow-up of patients with either MM or SMM compared to healthy controls. The data of 153 patients (105 with MM and 48 with SMM) and 138 controls were accessed from our medical center’s records between 2008 and 2015. We analyzed the patients’ data at diagnosis (baseline) and after 1, 3, and 5 years of follow-up.

Results
Patients with SMM had a significantly higher prevalence of diabetes, hypertension, and dyslipidemia at baseline compared to controls. A multivariate Cox regression analysis revealed a higher risk to develop dyslipidemia after 1, 3, and 5 years of follow-up among the SMM patients. The MM patients had a higher risk to develop diabetes after 1 year, hypertension after 5 years, and dyslipidemia after 1, 3, and 5 years of follow-up.

Conclusions
These data demonstrate that patients with SMM and those with MM are more prone to develop various components of metabolic syndrome, and they stress the importance of following-up metabolic syndrome components in both groups of patients.
Patient and tumour characteristics associated with inclusion in Cancer patient pathways in Norway in 2015–2016
Authors: Nilssen Yngvar , Brustugun Odd Terje , Eriksen Morten Tandberg , Haug Erik Skaaheim , Naume Bjørn , Møller Bjørn 
Published: May 2020

Abstract
Background
Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study were to see if the national target of 70% of all cancer patients being included in a CPP was met, and to identify factors associated with CPP inclusion.

Methods
All patients registered with a colorectal, lung, breast or prostate cancer diagnosis at the Cancer Registry of Norway in the period 2015–2016 were linked with the Norwegian Patient Registry for CPP information and with Statistics Norway for sociodemographic variables. Multivariable logistic regression examined if the odds of not being included in a CPP were associated with year of diagnosis, age, sex, tumour stage, marital status, education, income, region of residence and comorbidity.

Results
From 2015 to 2016, 30,747 patients were diagnosed with colorectal, lung, breast or prostate cancer, of whom 24,429 (79.5%) were included in a CPP. Significant increases in the probability of being included in a CPP were observed for colorectal (79.1 to 86.2%), lung (79.0 to 87.3%), breast (91.5 to 97.2%) and prostate cancer (62.2 to 76.2%) patients (p < 0.001). Increasing age was associated with an increased odds of not being included in a CPP for lung (p < 0.001) and prostate cancer (p < 0.001) patients. Colorectal cancer patients < 50 years of age had a two-fold increase (OR = 2.23, 95% CI: 1.70–2.91) in the odds of not being included in a CPP. The odds of no CPP inclusion were significantly increased for low income colorectal (OR = 1.24, 95%CI: 1.00–1.54) and lung (OR = 1.52, 95%CI: 1.16–1.99) cancer patients. Region of residence was significantly associated with CPP inclusion (p < 0.001) and the probability, adjusted for case-mix ranged from 62.4% in region West among prostate cancer patients to 97.6% in region North among breast cancer patients.

Conclusions
The national target of 70% was met within 1 year of CPP implementation in Norway. Although all patients should have equal access to CPPs, a prostate cancer diagnosis, older age, high level of comorbidity or low income were significantly associated with an increased odds of not being included in a CPP.
Short-term predictive potential of quantitative assessment of spinal cord impairment in patients undergoing French-door Laminoplasty for degenerative cervical myelopathy: preliminary results of an exploratory study exploiting intraoperative ultrasound data
Authors: Chen Guoliang , Li Jiachun , Wei Fuxin , Ji Qiao , Sui Wenyuan , Chen Bailing , Zou Xuenong , Xu Zuofeng , Liu Xizhe , Liu Shaoyu 
Published: May 2020

Abstract
Background
To study the correlation of neurological function in degenerative cervical myelopathy (DCM) patients with quantitative assessment of spinal cord compression and impairment by intraoperative ultrasound imaging (IOUSI).

Methods
Twenty-three patients who underwent French-Door laminoplasty for multilevel DCM were followed for 6 months. Modified Japanese Orthopaedic Association (mJOA) score and cervical MRI were assessed before surgery and at postoperative 6 months. IOUS, used to guide decompression, were recorded. The anteroposterior diameter (APD) and the gray values of the IOUSI hyperechogenicity of the midsagittal IOUSI at the narrowest level and at the lesion-free level, and the APD and traverse diameter at the traverse maximum compression level of IOUSI were measured. Maximum spinal cord compression (MSCC), compression rate (CR), and IOUSI gray value ratio (Rgray) were calculated. The appearance of preoperative T2W MRI increased signal intensity (ISI), and the signal change rate (SCR) on postoperative T2W MRI of 9 patients were also measured and calculated, and compared with that of IOUSI hyperechogenicity.

Results
Average mJOA score increased significantly from 11.57 ± 2.67 before surgery to 15.39 ± 1.50 at 6 months after surgery, with an average recovery rate (RR) of 71.11 ± 22.81%. The difference between the appearance of preoperative T2W MRI ISI and IOUSI hyperechogenicity was not significant. Spearman correlation analysis found that the IOUSI Rgray were negatively correlated with the RR of mJOA score with a coefficient of − 0.77, and the IOUSI Rgray was not correlated with the postoperative MRI SCR.

Conclusions
In DCM patients, the gray values of IOUSI can be measured accurately. The IOUSI Rgray correlated with postoperative neurological recovery significantly.
MiR-125 inhibited cervical cancer progression by regulating VEGF and PI3K/AKT signaling pathway
Authors: Fu Ke , Zhang Ling , Liu Rui , Shi Qi , Li Xue , Wang Min 
Published: May 2020

Abstract
Background
MiR-125 has been shown to be involved in a variety of cancers, including cervical cancer (CC). Here, our goal was to explore miR-125 functional role and molecular mechanism in cervical cancer development and progression.

Methods
qRT-PCR was employ to detect miR-125 and VEGF mRNA expression. Western blot was applied for testing protein levels (VEGF, E-cadherin, N-cadherin, vimentin, AKT, p-AKT, PI3K, and p-PI3K). MTT and transwell assays were used for detecting cervical cancer cell progression, including cell viability, migration, and invasion.

Results
We observed that miR-125 was downregulated, whereas VEGF was upregulated in cervical cancer tissues and cell lines (CaSki and SiHa). MiR-125 inhibited the proliferation, invasion, and migration by targeting VEGF in cervical cancer. Moreover, miR-125 negatively regulated VEGF expression in cervical cancer tissues. Finally, we demonstrated that miR-520d-5p inhibited the activation of PI3K/AKT signaling pathway.

Conclusion
In conclusion, the findings demonstrated that miR-125 inhibited cervical cancer progression and development by suppression VEGF and PI3K/AKT signaling pathway.