bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative analgesic efficacy of ear acupuncture in patients undergoing abdominal hysterectomy: a randomized controlled trial
Authors: Hendawy Hamdy A. , Abuelnaga Mohamed E. 
Published: November 2020

Abstract

Background
Numerous studies have revealed that acupuncture can increase the somatic pain threshold. Electro-acupuncture (EA) can help pain-relieving with minimal physiologic disturbance. Various painful disorders, as well as pain following various surgeries, like cesarean section, gastrostomy, and enterectomy were managed properly with acupuncture. Therefore we studied the postoperative analgesic effect of EA in patients undergoing abdominal hysterectomy.

Methods
A randomized, prospective clinical trial study was carried out on 56 women undergoing hysterectomy under spinal anesthesia. Patients were allocated randomly to receive either spinal anesthesia and electric ear acupuncture (EEA group) or spinal anesthesia alone (control group). EEA was done by fine needles to anatomically defined 4 points of the ear: Shen Men Point, thalamus Point 26, Analgesia Point 3, and Uterus Point 58, and connected to EA therapeutic apparatus. After finishing surgery, the fine needles were substituted by permanent press needles to be removed after 24 hours. The primary outcome was the postoperative 24 h morphine consumption by patient-controlled analgesia, while secondary outcomes included Post-operative pain scores and postoperative 1st request of analgesia.

Results
Total morphine consumption in the first 24 postoperative hours was obviously reduced in the EEA group versus the control group (mean ± SD:6.214± 2.1319 mg vs 15.714 ± 3.3428 mg, d = − 3.3886, 95% Confidence interval = − 4.2061,-2.5712, p-value =0.000). The postoperative pain scores were significantly reduced in the EEA group in comparison to the control group, with delayed 1st request of postoperative analgesia.

Conclusions
Electric ear acupuncture provides postoperative analgesia, reducing morphine requirement and consequently its side effects.

Trial registration
The trial was registered before enrolment of the first patient at the Pan African Clinical Trial Registry (www.pactr.org) database (PACTR201903770607799, Date of registration: 5th March 2019).
Effects of thiamine on vasopressor requirements in patients with septic shock: a prospective randomized controlled trial
Authors: Petsakul Suttasinee , Morakul Sunthiti , Tangsujaritvijit Viratch , Kunawut Parinya , Singhatas Pongsasit , Sanguanwit Pitsucha 
Published: November 2020

Abstract

Background
Thiamine, an essential vitamin for aerobic metabolism and glutathione cycling, may decrease the effects of critical illnesses. The objective of this study was to determine whether intravenous thiamine administration can reduce vasopressor requirements in patients with septic shock.

Methods
This study was a prospective randomized double-blind placebo-controlled trial. We included adult patients with septic shock who required a vasopressor within 1–24 h after admission between March 2018 and January 2019 at a tertiary hospital in Thailand. Patients were divided into two groups: those who received 200 mg thiamine or those receiving a placebo every 12 h for 7 days or until hospital discharge. The primary outcome was the number of vasopressor-free days over 7 days. The pre-defined sample size was 31 patients per group, and the study was terminated early due to difficult recruitment.

Results
Sixty-two patients were screened and 50 patients were finally enrolled in the study, 25 in each group. There was no difference in the primary outcome of vasopressor-free days within the 7-day period between the thiamine and placebo groups (mean: 4.9 days (1.9) vs. 4.0 days (2.7), p = 0.197, mean difference − 0.9, 95% CI (− 2.9 to 0.5)). However, the reductions in lactate (p = 0.024) and in the vasopressor dependency index (p = 0.02) at 24 h were greater among subjects who received thiamine repletion vs. the placebo. No statistically significant difference was observed in SOFA scores within 7 days, vasopressor dependency index within 4 days and 7 days, or 28-day mortality.

Conclusions
Thiamine was not associated to a significant reduction in vasopressor-free days over 7-days in comparison to placebo in patients with septic shock. Administration of thiamine could be associated with a reduction in vasopressor dependency index and lactate level within 24 h. The study is limited by early stopping and low sample size.

Trial registration
TCTR, TCTR20180310001. Registered 8 March 2018, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=3330.
Effectiveness of clinical breast examination as a ‘stand-alone’ screening modality: an overview of systematic reviews
Authors: Ngan Tran Thu , Nguyen Nga T. Q. , Van Minh Hoang , Donnelly Michael , O’Neill Ciaran 
Published: November 2020

AbstractBackgroundThere is uncertainty about the effectiveness of clinical breast examination (CBE) and conflicting recommendations regarding its usefulness as a screening tool for breast cancer. This paper provides an overview of systematic reviews that assessed the effectiveness of CBE as a ‘stand-alone’ screening modality for breast cancer compared to no screening and focused on its value in low- and middle-income countries (LMICs).MethodsWe searched MEDLINE, EMBASE, Scopus, Web of Science, and the Cochrane Database of Systematic Reviews for systematic reviews reporting the effectiveness of CBE published prior to October 29, 2019. The main outcomes assessed were mortality and down staging. The AMSTAR 2 checklist was used to assess the methodological quality of the reviews including risk of bias.ResultsEleven systematic reviews published between 1993 and 2019 were identified. There was no direct evidence that CBE reduced breast cancer mortality. Indirect evidence suggested that a well-performed CBE achieved the same effect as mammography regarding mortality despite its apparently lower sensitivity (40–69% for CBE vs 77–95% for mammography). Greater sensitivity was recorded among younger and Asian women. Moreover, CBE contributed between 17 and 47% of the shift from advanced to early stage cancer.ConclusionsCBE merits attention from health system and service planners in LMICs where a national screening programme based on mammography would be prohibitively expensive. In particular, it is likely that considerable value would be gained from conducting implementation scientific research in countries with large numbers of Asian women and/or where younger women are at higher risk.RegistrationPROSPERO, registration numberCRD42019126798.
Exposure to family violence from childhood to adulthood
Authors: Shields Margot , Tonmyr Lil , Hovdestad Wendy E. , Gonzalez Andrea , MacMillan Harriet 
Published: November 2020

Abstract

Background
Both childhood maltreatment (CM) and intimate partner violence (IPV) are public health problems that have been related to a wide range of adverse health consequences. However, studies examining associations between specific types of CM and experiencing IPV in adulthood have yielded conflicting results.

Methods
Using data from 10,608 men and 11,458 women aged 18 or older from Canada’s 2014 General Social Survey, we examined associations between three types of CM—childhood physical abuse (CPA), childhood sexual abuse (CSA), and childhood exposure to IPV —and subsequent intimate partner violence (IPV) in adulthood (physical, sexual or emotional).

Results
When potential confounders were controlled, CPA, CSA and childhood exposure to IPV were associated with IPV in adulthood for both sexes (odds ratios, 1.7, 1.8 and 2.0 for men, and 2.2, 2.0 and 2.1 for women). When severity and frequency of CM were examined, a dose-response relationship between all three types of CM and IPV in adulthood was observed among women (meaning that as the severity/frequency of CM increased, the likelihood of reporting IPV also increased); among men, a dose-response relationship was observed only for CPA.

Conclusions
The association between CM and IPV in adulthood is particularly concerning because experiencing multiple forms of trauma has cumulative effects. Lifespan studies have shown that individuals who experience multiple incidents of abuse exhibit the highest levels of impairment. This underscores the importance of programs to eradicate both CM and IPV. This underscores the importance of programs to eradicate both CM and IPV. Future research should focus on assessing interventions designed to promote healthy relationships and the provision of emotional support and coping mechanisms to children and families in abusive situations.
The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study
Authors: Sang Ling , Chen Sibei , Zheng Xia , Guan Weijie , Zhang Zhihui , Liang Wenhua , Zhong Ming , Jiang Li , Pan Chun , Zhang Wei , Xia Jiaan , Chen Nanshan , Wu Wenjuan , Wu Hongkai , Xu Yonghao , Liu Xuesong , Liu Xiaoqing , He Jianxing , Li Shiyue , Zhang Dingyu , Zhong Nanshan , Li Yimin 
Published: November 2020

Abstract

Background
The clinical correlates, prognosis and determinants of acute kidney injury (AKI) in patients with coronavirus disease 2019 (Covid-19) remain largely unclear.

Methods
We retrospectively reviewed medical records of all adult patients with laboratory-confirmed Covid-19 who were admitted to the intensive care unit (ICU) between January 23rd 2020 and April 6th 2020 at Wuhan JinYinTan Hospital and The First Affiliated Hospital of Guangzhou Medical University.

Results
Among 210 patients, 131 were males (62.4%). The median Age was 64 years (IQR: 56–71). Of 92 (43.8%) patients who developed AKI during hospitalization, 13 (14.1%), 15 (16.3%) and 64 (69.6%) were classified as being at stage 1, 2 and 3, respectively. 54 patients (58.7%) received continuous renal replacement therapy. Age, sepsis, nephrotoxic drug, invasive mechanical ventilation and elevated baseline serum creatinine levels were associated with the occurrence of AKI. Renal recovery during hospitalization was identified among 16 patients with AKI (17.4%), who had a significantly shorter time from admission to AKI diagnosis, lower incidence of right heart failure and higher ratio of partial pressure of oxygen to the fraction of inspired oxygen. Of 210 patients, 93 deceased within 28 days of ICU admission. AKI stage 3, critical disease, greater Age and the lowest ratio of partial pressure of oxygen to the fraction of inspired oxygen being < 150 mmHg were independently associated with death.

Conclusions
Among patients with Covid-19, the incidence of AKI was high. Our findings of the risk factors of the development of AKI and factors associated with renal function recovery may inform clinical management of patients with critical illness of Covid-19.
Overview and factors associated with pregnancies and abortions occurring in sex workers in Benin
Authors: Perrault Sullivan Gentiane , Guédou Fernand Aimé , Batona Georges , Kintin Frédéric , Béhanzin Luc , Avery Lisa , Bédard Emmanuelle , Gagnon Marie-Pierre , Zannou Djimon Marcel , Kpatchavi Adolphe , Alary Michel 
Published: November 2020

AbstractBackgroundBehavioural and structural factors related to sex work, place female sex workers (FSWs) at high risk of maternal mortality and morbidity (MMM), with a large portion due to unintended pregnancies and abortions. In the African context where MMM is the highest in the world, understanding the frequency and determinants of pregnancy and abortion among FSWs is important in order to meet their sexual and reproductive health needs.MethodsData from two Beninese cross-sectional surveys among FSWs aged 18+ (2013,N = 450; 2016,N = 504) were merged. We first performed exploratory univariate analyses to identify factors associated with pregnancy and abortion (p < 0.20) using Generalized Estimating Equations with Poisson regression and robust variance. Multivariate analyses first included all variables identified in the univariate models and backward selection (p ≤ 0.05) was used to generate the final models.ResultsMedian age was 39 years (N = 866). The proportion of FSWs reporting at least one pregnancy during sex work practice was 16.4%, of whom 42.3% had more than one. Most pregnancies ended with an abortion (67.6%). In multivariate analyses, younger age, longer duration in sex work, previous HIV testing, having a boyfriend and not using condoms with him were significantly (p < 0.05) associated with more pregnancies.ConclusionOne FSW out of five had at least one pregnancy during her sex work practice. Most of those pregnancies, regardless of their origin, ended with an abortion. Improving access to various forms of contraception and safe abortion is the key to reducing unintended pregnancies and consequently, MMM among FSWs in Benin.
Pharmacodynamics and pharmacokinetics of a new type of recombinant insulin Lisargine injection
Authors: Lu Jiangjie , Zeng Yong , Yi Xiulin , Zhang Hongmei , Zhu Lin , Jiang Lixin , Li Jing , Zhou Wei , Zhu Hong , Xiong Aijun 
Published: November 2020

AbstractBackgroundRecombinant insulin Lisargine is a new type of insulin. In this study, we aimed to compare its pharmacodynamic (PD) and pharmacokinetic (PK) with Lantus.MethodsThe PD test was performed by exploring the effect of single administration on blood glucose of normal rats and STZ-induced diabetic rats, and the effect of multiple administrations on blood glucose of STZ-induced diabetic rats. Further PD tests include receptor affinity test, receptor autophosphorylation test and adipocyte glucose uptake test. Four IU and 8 IU per dog Lisargine was used for PK test, insulin was measured and area under curve (AUC) was calculated.ResultsWith single injection, Lisargine 1.5 IU/kg had significant hypoglycemic effects at 1 and 2 h, similar to that of Lantus. Lisargine 5 IU/kg and 10 IU/kg lowered the blood glucose of STZ-induced diabetic rats at 1, 2, 4 & 6 h significantly. With multiple injections, Lantus lowered blood glucose at 2, 4 & 6 h, Lisargine 2.5 IU/kg, 5 IU/kg, and 10 IU/kg lowered blood glucose at 2 & 4 h significantly, compared with vehicle. There was no difference for receptor affinity test, receptor autophosphorylation test and adipocyte glucose uptake test between Lisargine and Lantus. The PK of Lisargine and Lantus of healthy Beagle dogs was very similar.ConclusionsThis animal study demonstrated that PK and PD of Lisargine and Lantus were similar, suggesting the bioequivalence of these products.
The risk of new-onset atrial fibrillation in patients with type 2 diabetes mellitus treated with sodium glucose cotransporter 2 inhibitors versus dipeptidyl peptidase-4 inhibitors
Authors: Ling Ann Wan-Chin , Chan Cze-Ci , Chen Shao-Wei , Kao Yi-Wei , Huang Chien-Ying , Chan Yi-Hsin , Chu Pao-Hsien 
Published: November 2020

AbstractBackgroundSodium glucose cotransporter 2 inhibitor (SGLT2i) reduces the risk of hard cardiovascular endpoints in type 2 diabetes mellitus (T2DM) patients with/without established cardiovascular diseases. Whether SGLT2i is associated with a lower risk of new-onset atrial fibrillation (AF) in T2DM patients is unclear. We aimed to evaluate the risk of new-onset AF associated with the use of SGLT2i compared to dipeptidyl peptidase-4 inhibitor (DPP4i) among a longitudinal cohort of diabetic patients.MethodsWe used medical data from a multi-center healthcare provider in Taiwan, which included a total of 15,606 and 12,383 patients treated with SGLT2i and DPP4i, respectively, from June 1, 2016 to December 31, 2018. We used propensity-score weighting to balance covariates across study groups. Patients were followed up from the drug index date until the occurrence of new-onset AF, discontinuation of the index drug, or the end of the study period, whichever occurred first.ResultsOverall, 55%, 45%, and 0% of the patients were treated with empagliflozin, dapagliflozin, and canagliflozin, respectively. Most patients in the DPP4i group were prescribed with linagliptin (51%), followed by sitagliptin (24%), saxagliptin (13%), vildagliptin (8%) and alogliptin (5%). The use of SGLT2i was associated with a lower risk of new-onset AF compared with DPP4i after propensity-score weighting [hazard ratio: 0.61; 95% confidential interval: 0.50–0.73;P < 0.001]. Subgroup analysis revealed that the use of SGLT2i was associated with a lower risk of new-onset AF compared with DPP4i across several subgroups including old age, female in gender, the presence of cardiovascular disease, hemoglobin A1c$$\ge$$≥8%, and chronic kidney disease. The advantage of SGLT2i over DPP4i persisted with different SGLT2i (dapagliflozin or empagliflozin) and either low- or standard-dose SGLT2i.ConclusionsSGLT2i was associated with a lower risk of new-onset AF compared with DPP4i among T2DM patients in real-world practice.
[68Ga]Ga-PSMA-11 PET before and after initial long-term androgen deprivation in patients with newly diagnosed prostate cancer: a retrospective single-center study
Authors: Hoberück Sebastian , Löck Steffen , Winzer Robert , Zöphel Klaus , Froehner Michael , Fedders Dieter , Kotzerke Jörg , Hölscher Tobias 
Published: November 2020

Abstract

Purpose
The study aimed to evaluate the effect of androgen deprivation therapy (ADT) on PSMA imaging and its correlation to the PSA concentration by comparing qualitative and quantitative parameters: SUVmax, SUVmean, PSMA-derived tumor volume (PSMA-TV), total lesion PSMA (TL-PSMA) and molecular imaging (mi)PSMA score.

Methods
Retrospective analysis of 21 therapy-naïve patients with oligometastatic prostate cancer (median age 70 years) who underwent either [68Ga]Ga-PSMA-11-PET/CT or -PET/MRI before initiation of (T1) as well as during ADT (T2). The median duration of ADT was 155 days (range 61–289 days). All lesions were analyzed using several qualitative and quantitative PET parameters.

Results
A total of 109 PSMA-positive lesions (24 intraprostatic, 56 lymphonodal and 29 osseous) were visually detected at any of the examinations, while at T2, two new bone lesions were detected in one patient. During ADT, all patients experienced a decrease in their PSA level (median: 29.1 before vs. 0.71 after; p < 0.001). During long-term ADT, a relevant decrease in lesion count occurred, especially in patients with a T2 PSA value < 1 ng/ml (median: 4 vs. 0.9; p = 0.007) and PSMA expression, which resulted in miN- and/or miM-downstaging in 11 patients (52.7%).
All analyzed PET parameters correlated strongly with each other. The PSA level at T2 correlated modestly with the decrease in PSMA expression and its derived volumes.

Conclusion
Post-ADT scans detected, especially in patients with a residual PSA < 1 ng/ml, fewer PSMA-positive lesions with overall lower PSMA expression, regardless of primary tumor site or metastatic sites. None of the PET parameters has proven to be superior, as they all correlated modestly with the PSA value at T2. Thus, the simply acquirable miPSMA score seems to be the most suitable for evaluating the effect of ADT on PSMA expression.
On $$\psi _{{\mathcal{H}}}( . )$$-operator in weak structure spaces with hereditary classes
Authors: Abu-Donia H. M. , Hosny Rodyna A. 
Published: November 2020

Abstract
Weak structure space (briefly, wss) has master looks, when the whole space is not open, and these classes of subsets are not closed under arbitrary unions and finite intersections, which classify it from typical topology. Our main target of this article is to introduce $$\psi _{{\mathcal {H}}}(.)$$

ψ
H

(
.
)

-operator in hereditary class weak structure space (briefly, $${\mathcal {H}}wss$$

H
w
s
s

) $$(X, w, {\mathcal {H}})$$

(
X
,
w
,
H
)

and examine a number of its characteristics. Additionally, we clarify some relations that are credible in topological spaces but cannot be realized in generalized ones. As a generalization of w-open sets and w-semiopen sets, certain new kind of sets in a weak structure space via $$\psi _{{\mathcal {H}}}(.)$$

ψ
H

(
.
)

-operator called $$\psi _{{\mathcal {H}}}$$

ψ
H

-semiopen sets are introduced. We prove that the family of $$\psi _{{\mathcal {H}}}$$

ψ
H

-semiopen sets composes a supra-topology on X. In view of hereditary class $${\mathcal {H}}_{0}$$

H
0

, $$w T_{1}$$

w

T
1

-axiom is formulated and also some of their features are investigated.
Life cycle assessment and leather production
Authors: Navarro Diego , Wu Jianhui , Lin Wei , Fullana-i-Palmer Pere , Puig Rita 
Published: November 2020

Abstract
Leather industry is facing new trends on production and consumption patterns due to society concerns. Circular economy is proposing a transition from the current economic model to a more sustainable one, in which waste is designed out and resources will be reused and recycled as long as possible. In this transition, Life Cycle Assessment (LCA) is an important tool to help decision-making. In the present review, 39 English-written peer-reviewed papers related to LCA and leather have been found, 30 of which were published in the last 6 years, meaning LCA is nowadays an important subject. Papers are presented within 4 types, focused on: 1) the whole leather production process, 2) a single step in the production process (e.g, new technologies for unhairing), 3) waste treatment and recycling, and 4) life cycle thinking with ideas on long-term strategies for leather industries. As discussed in the literature review, leather industry has important challenges to address: increasing sustainability and transparency on the supply chain, and strengthening the beauty of leather. Taking up these challenges from a life cycle perspective will help leather industry flourish in the coming future.

Graphical abstract