bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbid Traumatic Brain Injury and Visual Impairment: Vocational Rehabilitation Service Provision and Agency-Level Outcomes
Authors: McDonnall Michele C. , Cmar Jennifer L. , Lund Emily M. 
Published: December 2019

Introduction: The purpose of this study was to investigate how services are provided to state–federal vocational rehabilitation consumers with comorbid traumatic brain injury (TBI) and visual impairment and the prevalence of and competitive employment rates for this population. Methods: We utilized a mixed-methods approach by incorporating interview data from 51 vocational rehabilitation agency administrators (to identify strategies used to serve these consumers) and case service data (to identify prevalence and competitive employment rates at the agency level). We combined the data to examine the relationship between strategies used and the prevalence of and employment outcomes for this population. A modified grounded theory approach was used for qualitative data analysis and descriptive statistics, and analyses of variance were used for quantitative data analyses. Results: Strategies used to serve these consumers included collaboration between counselors, involvement of external organizations, specialized TBI units or caseloads, staff training in TBI, and personnel with dual expertise in TBI and visual impairment. Over a third of agency administrators reported that they did not do anything special or different to serve this population. The average percentage of consumers with visual impairments who also had TBIs being served by agencies was 2.1%. Their average competitive employment rate by agency was 43.2%. Employing staff with dual expertise in TBI and visual impairment was associated with serving a greater percentage of consumers and having a higher competitive employment rate. Discussion: No agencies had a unique service delivery program or method to serve this population, perhaps due to its low prevalence. Agencies had substantial variability in the proportion of consumers with TBI and visual impairment served and their competitive employment rates. Implications for practitioners: Training vocational rehabilitation professionals to develop expertise in both TBIs and visual impairments may help agencies better serve these consumers.
Early detection of recurrent laryngeal nerve damage using intraoperative nerve monitoring during thyroidectomy
Authors: Yu Tian , Wang Fei-liang , Meng Ling-bing , Li Jian-kun , Miao Gang 
Published: December 2019

Objective This study aimed to investigate risk factors for early recurrent laryngeal nerve (RLN) damage during thyroid surgery with intraoperative nerve monitoring (IONM) technology to avoid RLN damage during surgery. Methods Data were retrospectively collected from 93 patients who underwent thyroidectomy at Beijing Hospital. All operations were performed by the same surgeon. A four-step procedure of IONM was used during the operation to determine the amplitude and latency of the RLN. Results The majority (51.6%) of patients who underwent surgery had thyroid carcinoma. Lymphadenectomy was carried out in 55 (59.1%) patients. A strong association was observed between temporary injury of the RLN and the extent of resection. The risk of temporary injury of the RLN during total thyroidectomy was three times that during right thyroid lobectomy (odds ratio = 3.13). The results of left lobectomy were also different from those of right lobectomy because the RLN was more likely to be damaged during left lobectomy. Conclusions Assessment of the amplitude and latency of the RLN can help to assess the integrity of the RLN. The extent of resection affects the functional integrity of the RLN.
Implanting totally implantable venous access ports in the upper arm is feasible and safe for patients with early breast cancer
Authors: Xu Haiping , Chen Rui , Jiang Chaojun , You Sainan , Zhu Qiannan , Li Yan , Li Shuo , Zha Xiaoming , Wang Jue 
Published: December 2019

Purpose: Totally implantable venous access ports are widely used in chemotherapy for malignant tumors. This retrospective study investigated the safety, technical feasibility, and device-related complications of totally implantable venous access ports implanted in the upper arm. Methods: Between May 2016 and June 2018, 570 women with early breast cancer received chemotherapy and were successfully implanted with a totally implantable venous access port in the upper arm. Device-related complications were collected and influencing factors were analyzed for major complications. Results: Only one case underwent premature port removal before the end of chemotherapy. Device-related complications were observed in 32 cases, including 31 late complications. The rate of complications was 0.263/1000 catheter-days. Infection and thrombosis were the most common complications, occurring in 13 and 8 cases, respectively. Other complications were catheter occlusion, catheter dislocation, arrhythmia, and so on. Patients with higher body mass index were significantly more prone to infection and those who experienced catheter-related thrombosis had longer implantation times and higher body mass indices. Conclusion: Implanting totally implantable venous access ports in the upper arm is feasible and safe for patients with early breast cancer, with a low rate of complications, providing good alternative to central venous ports.
Perfluoroalkyl substances and likelihood of stroke in persons with and without diabetes
Authors: Hutcheson Robert , Innes Kim , Conway Baqiyyah 
Published: December 2019

Objective: The main objective of this study is to evaluate the relationship of perfluoroalkyl substances with stroke and any modifying influence of diabetes. Methods: Data on 3921 adults aged ⩾20 years with and 44,285 without diabetes were drawn from the C8 Health Project. Four perfluoroalkyl substances were investigated: perfluorohexane sulphate, C8 – perfluorooctanoic acid, perfluoroctane sulfonate and perfluorononaoic acid. Results: There were 238 cases of stroke among those with and 643 among those without diabetes. In analyses controlled for age, sex, race, diabetes duration, body mass index, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, kidney function and a history of smoking, a history of stroke was significantly inversely associated with serum perfluorohexane sulphate (odds ratio = 0.75, 0.64–0.88) and perfluoroctane sulfonate (odds ratio = 0.81, 0.70–0.90), but not perfluorooctanoic acid (odds ratio = 1.04, 0.94–1.15) or perfluorononaoic acid (odds ratio = 0.89, 0.70–1.14) among those with diabetes. Perfluoroalkyl substances demonstrated no association with stroke among those without diabetes ( p interaction = 0.006 and 0.01 for perfluorohexane sulphate and perfluorooctanoic acid, respectively). Conclusion: In this large cross-sectional study, serum levels of perfluorohexane sulphate and perfluoroctane sulfonate were inversely associated with stroke among those with diabetes. Although mechanisms and implications for this diabetes-specific inverse relationship need to be further explored, our data suggest that perfluoroalkyl substances do not increase risk of stroke among persons with or without diabetes.
Primary conservative treatment for peritonitis-absent symptomatic isolated dissection of the superior mesenteric artery with severely compressed true lumen
Authors: Fang Gang , Xu Genying , Fang Yuan , Yang Jue , Pan Tianyue , Jiang Xiaolang , Dong Zhihui , Fu Weiguo 
Published: December 2019

Objectives The purpose of this study was to evaluate the safety and efficacy of primary conservative treatment (PCT) for peritonitis-absent symptomatic spontaneous isolated dissection of the superior mesenteric artery (S-SIDSMA) with severely compressed true lumen. Methods From January 2013 to December 2018, PCT was used in 26 cases of peritonitis-absent S-SIDSMA with severely compressed true lumen in our center based on our previous proposed treatment algorithm for S-SIDSMA. The demographics, duration from the onset to the admission, duration from the start of the conservative treatment to the alleviation of the symptoms, and in-hospital and follow-up clinical and angiographic outcomes were prospectively recorded and then analyzed. Results Among the 26 included patients, 84.6% were male. The mean age of the patients was 54.7 years. The mean duration from the onset to the admission was 3.1 days (range, 1–14 days). Symptoms in 22 patients were markedly or completely relieved during the first five-day medical treatment. Endovascular stent placement was attempted in the remaining four patients, which was successfully performed in three (75%) of them. The technical failure occurred in a patient whose compressed true lumen failed to be cannulated. Medical treatment was then continued in this patient, and his symptoms were relieved after a two-day medical treatment. During the mean follow-up period of 14.3 months, endovascular stent placement was performed in three patients due to the recurrence of the abdominal pain and the chronic intestinal ischemia. No patient showed dissection progression during the follow-up. The complete remodeling rate of the stent group was significantly higher than that of the medical group (83.3% vs. 25%, P = 0.021). Conclusions Based on our previous proposed treatment algorithm for S-SIDSMA, PCT could achieve satisfactory results both clinically and morphologically in peritonitis-absent S-SIDSMA with severely compressed true lumen.
Chronic progressive pulmonary paracoccidioidomycosis in a female immigrant from Venezuela
Authors: Kayser Moritz , Rickerts Volker , Drick Nora , Gerkrath Jasmin , Kreipe Hans , Soudah Bisharah , Welte Tobias , Suhling Hendrik 
Published: December 2019

Paracoccidioidomycosis (PCM) is a fungal infection caused by Paracoccidioides brasiliensis and P. lutzii. It is endemic to South and Central America. While PCM frequently remains latent, the disease can reactivate years after the initial infection. As the disease is rare outside the endemic area, and symptoms can mimic other pulmonary diseases, correct diagnosis can be challenging for clinicians in developed countries. In this report, we present the case of a 57-year-old female Venezuelan immigrant with PCM. She was initially misdiagnosed with sarcoidosis and treated with corticosteroids, leading to an exacerbation of the infection requiring intensive care. Because cultivation of Paracoccidioides sp. is slow and unsensitive, we opted for microscopic observation of fungal elements and molecular testing on a tissue biopsy and bronchoalveolar lavage (BAL) together with antibody detection. This allowed the diagnosis of PCM, enabling specific management. PCM and other imported mycoses should be considered as a differential diagnosis in patients originating from South and Central America displaying symptoms suggestive of sarcoidosis. The reviews of this paper are available via the supplemental material section.
Clinical relevance of neutralizing antibodies in botulinum toxin long-term treated still-responding patients with cervical dystonia
Authors: Hefter Harald , Rosenthal Dietmar , Bigalke Hans , Moll Marek 
Published: December 2019

Background: The aim of the study was to test the clinical relevance of neutralizing antibodies (NABs) in patients with cervical dystonia (CD) still responding to repeat injections with botulinum toxin type A (BoNT/A). Methods: Enzyme-linked immunosorbent assay (ELISA)-test evidence from a cross-sectional study on 221 CD-patients with treatment durations of between 2 and 21 years and still responding to repeat BoNT/A-injections showed the presence of antibodies against BoNT/A in 39 patients. A mouse hemi-diaphragm (MHDA) confirmation test was performed in these 39 ELISA-positive patients, and demographic (age, sex, age at onset of CD) and treatment-related (duration of treatment, mean dose of the last 10 injections, TSUI-score, patient’s subjective scoring of the treatment effect, patient’s scoring of quality of life by means of the CDQ24-questionnaire) data from these 39 patients were compared with data from ELISA-negative patients. Paralysis time, the MHDA outcome measure, was correlated with clinical data. Results: The ELISA-positive CD-patients had significantly higher TSUI-scores ( p < 0.015), and had been treated for significant longer ( p < 0.022) and with significantly higher doses ( p < 0.001). Patient’s rating of BoNT/A-treatment effect and quality of life tended to be worse in ELISA-positive compared with ELISA-negative patients. The paralysis time of ELISA-positive patients was significantly correlated with the mean dose of the last 10 injections ( p < 0.027) and the pain subscore of the CDQ24 ( p < 0.012). Conclusions: Presence of NABs is clinically relevant in CD, leading to a significantly worse head position, therapy with significantly higher BoNT/A doses, and a correlation between the CDQ24 pain-subscore and antibody titers.
Swelling characteristics of bentonite after long-term dissolution in alkaline solution
Authors: Xiang Guo-sheng , Ye Wei-min , Lv Li-yong 
Published: December 2019

AbstractIn a high-level radioactive waste repository, bentonite may react with the alkaline solution produced by cement degradation. In this study, bentonite was mixed with alkaline solution in a closed system and reacted for 3–24 months. Furthermore, swelling tests were conducted on the alkaline-dissolved bentonite immersed in distilled water. The swelling deformation decreased significantly with increases in the concentration of NaOH solution and reaction time, and this was mainly due to montmorillonite dissolution. The fractal e–p relationship (e is the void ratio and p is the vertical pressure) with two calculation coefficients (the swelling coefficient and the fractal dimension) was employed to determine the swelling of alkaline-dissolved bentonite. The fractal dimension increased slightly with increasing reaction time or concentration of NaOH solution, as the dissolution traces caused by the alkaline solution favoured an increase in the irregularity and fractality of the bentonite surface. The swelling coefficient decreased linearly with decreasing montmorillonite content. In addition, the swelling coefficient and the fractal dimension were related exponentially to the reaction time in alkaline solution. A relationship between the swelling of alkaline-dissolved samples and the reaction time was proposed, which might be used to assess the swelling properties of bentonite barriers that would be affected by long-term dissolution of the alkaline solution in a closed repository.
TRPM8 genetic variant is associated with chronic migraine and allodynia
Authors: Ling Yu-Hsiang , Chen Shih-Pin , Fann Cathy Shen-Jang , Wang Shuu-Jiun , Wang Yen-Feng 
Published: December 2019

Abstract
Background
Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We aimed to investigate the associations of pre-identified migraine susceptibility loci in Taiwanese with migraine endophenotypes or subtypes, including chronic migraine and allodynia.

Methods
The associations of six SNPs identified from our previous study, including TRPM8 rs10166942, LRP1 rs1172113, DLG2 rs655484, GFRA1 rs3781545, UPP2 rs7565931, and GPR39 rs10803531, and migraine endophenotypes, including chronic migraine and allodynia were tested. Significant associations in the discovery cohort were validated in the replication cohort. The adjusted odds ratios (aOR) were calculated after controlling for confounders.

Results
In total, 1904 patients (mean age 37.5 ± 12.2 years old, female ratio: 77.7%) including 1077 in the discovery cohort and 827 in the replication cohort were recruited. Of them, 584 (30.7%) had chronic migraine. Of the 6 investigated SNPs, TRPM8 rs10166942 T allele-carrying patients were more likely to have chronic migraine than non-T allele carriers in both discovery and replication cohorts and combined samples (33.7% vs. 25.8%, p = 0.004, aOR = 1.62). In addition, T allele carriers reported more allodynic symptoms than non-T allele carriers (3.5 ± 3.7 vs. 2.6 ± 2.8, p < 0.001). However, allodynia severity did not differ between episodic and chronic migraine patients. No further correlations between genetic variants and endophenotypes were noted for the other SNPs.

Conclusions
TRPM8 may contribute to the pathogenesis of chronic migraine. However, our study did not support allodynia as a link between them. The underlying mechanisms deserve further investigations.
The long noncoding RNA LINC00483 promotes lung adenocarcinoma progression by sponging miR-204-3p
Authors: Yang Shengzhuang , Liu Tao , Sun Yu , Liang Xiangsen 
Published: December 2019

Abstract
Background
The expression of the long noncoding RNA LINC00483 is upregulated in lung adenocarcinoma (LUAD). However, its role in the progression of LUAD and the underlying mechanisms remain elusive.

Methods
The expressions of LINC00483 and miR-204-3p were determined using quantitative real-time PCR. The correlation between the clinicopathological characteristics of LUAD patients and LINC00483 expression was analyzed using Pearson’s χ2 test. A549 and PC-9 cells were transfected with small interfering RNA (siRNA) that specially targeting LINC00483 to assess the impact of its knockdown. Cell proliferation was assessed using the Cell Counting Kit-8 and clone forming assays. Cell migration and cell invasion were evaluated using a transwell assay. The levels of Snail, E-cadherin, N-cadherin and ETS1 proteins were determined via western blotting. The interaction between LINC00483 and miR-204-3p was analyzed using dual-luciferase, fluorescence in situ hybridization and RNA immunoprecipitation.

Results
LINC00483 was upregulated in LUAD tissues and cell lines. Higher LINC00483 levels closely correlated to shorter survival times, advanced TNM stage, larger tumor size and positive lymph node metastasis. Cell proliferation, migration and invasion were suppressed after LINC00483 knockdown. LINC00483 mainly localized in the cytoplasm, where it acted as a sponge of miR-204-3p. ETS1 was validated as a downstream target of miR-204-3p and is thus regulated by LINC00483.

Conclusion
This study demonstrated that LINC00483 facilitates the proliferation, migration and invasion of LUAD cells by acting as a sponge for miR-204-3p, which in turn regulates ETS1.
The Study of Enhanced High-Intensity Focused Ultrasound Therapy by Sonodynamic N2O Microbubbles
Authors: Zhong Xiaowen , Zhang Mei , Tian Zedan , Wang Qi , Wang Zhigang 
Published: December 2019

AbstractHigh-intensity focused ultrasound (HIFU) is a representative non-invasive method of cancer therapy, but its low therapeutic efficacy and risk of damage to surrounding normal tissue hinder its further clinical development and application. Sonodynamic therapy (SDT) kills tumor cells through reactive oxygen molecules produced by sonosensitizers during ultrasound treatment. SDT can enhance HIFU efficacy like microbubbles. In this work, we developed nanoscale N2O microbubbles (N2O-mbs) by an improved mechanical oscillation method. These microbubbles showed good biocompatibility and tumor cell binding. The sonosensitivity of the N2O-mbs was detected both extracellularly and intracellularly through the detection of reactive oxygen species generation. The toxic effects of these sonodynamic microbubbles on tumor cells and the synergistic effect on HIFU treatment were evaluated. Significant apoptosis was caused by reactive oxygen species produced by N2O-mbs under ultrasound irradiation. N2O-mbs combined with HIFU increased tumor cell necrosis and apoptosis in vitro and the coagulative necrotic volume and echo intensity in the bovine liver target area ex vivo. These sonodynamic microbubbles have been also demonstrated to efficiently inhibit tumor growth in vivo. N2O-mbs have a significant impact on the treatment and ablation effect of HIFU due to the advantages of microbubble and extraordinary sonosensitivity. This finding suggests that N2O-mbs may be a novel auxiliary agent for ultrasound that can be used to promote HIFU tumor thermal ablation.
Photogalvanic Effect in Nitrogen-Doped Monolayer MoS2 from First Principles
Authors: Luo Wen-Ming , Shao Zhi-Gang , Yang Mou 
Published: December 2019

AbstractWe investigate the photogalvanic effect in nitrogen-doped monolayer molybdenum disulfide (MoS2) under the perpendicular irradiation, using first-principles calculations combined with non-equilibrium Green function formalism. We provide a detailed analysis on the behavior of photoresponse based on the band structure and in particular the joint density of states. We thereby identify different mechanisms leading to the existence of zero points, where the photocurrent vanishes. In particular, while the zero point in the linear photovoltaic effect is due to forbidden transition, their appearance in the circular photovoltaic effect results from the identical intensity splitting of the valance band and the conduction band in the presence of Rashba and Dresslhaus spin-orbit coupling. Furthermore, our results reveal a strong circular photogalvanic effect of nitrogen-doped monolayer MoS2, which is two orders of magnitude larger than that induced by the linearly polarized light.
Lithia-Based Nanocomposites Activated by Li2RuO3 for New Cathode Materials Rooted in the Oxygen Redox Reaction
Authors: Lee Byeong Gwan , Park Yong Joon 
Published: December 2019

AbstractLithia-based materials are promising cathodes based on an anionic (oxygen) redox reaction for lithium ion batteries due to their high capacity and stable cyclic performance. In this study, the properties of a lithia-based cathode activated by Li2RuO3 were characterized. Ru-based oxides are expected to act as good catalysts because they can play a role in stabilizing the anion redox reaction. Their high electronic conductivity is also attractive because it can compensate for the low conductivity of lithia. The lithia/Li2RuO3 nanocomposites show stable cyclic performance until a capacity limit of 500 mAh g−1 is reached, which is below the theoretical capacity (897 mAh g−1) but superior to other lithia-based cathodes. In the XPS analysis, while the Ru 3d peaks in the spectra barely changed, peroxo-like (O2)n− species reversibly formed and dissociated during cycling. This clearly confirms that the capacity of the lithia/Li2RuO3 nanocomposites can mostly be attributed to the anionic (oxygen) redox reaction.