bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación de software en la producción de objetos en Realidad Aumentada con fines educativos
Authors: Cabero Almenara Julio , Llorente Cejudo Carmen 
Published: December 2019

El interés del presente artículo está destinado a evaluar las posibilidades que ofrece el software de producción de Realidad Aumentada (RA) existente en el momento actual para su incorporación en el ámbito educativo, con el objeto de identificar aquellas características que se adecuen a las necesidades de los docentes que pretendan diseñarlos, producirlos e incorporarlos a sus aulas. Para ello se construyó un cuestionario destinado a indagar sobre el grado de conocimiento que los expertos que evaluaron los diferentes software poseían de diferentes programas existentes en el mercado para la producción de objetos en RA. Entre los resultados obtenidos, destacar que, ante la falta de estudios que valoren el software de producción de objetos de aprendizaje en RA, el presente trabajo aporta indicaciones, tanto para la selección del mismo, como para tener criterios para su valoración. De las conclusiones obtenidas, destacar que el trabajo ha permitido identificar los diez programas que son más conocidos por los expertos en los momentos en los cuales se realizan, como por ejemplo: Arlab, Armedia, Arpa, ARTTolkit, Aurasma, Blippar, Designers artoolkit, Layar, Vuforia y Wikitude.
This article has the main interest to evaluate the possibilities offered by the existing Augmented Reality (AR) production software for its incorporation into the educational field, in order to identify those characteristics that meet the needs of teachers who intend to design, produce and incorporate them into their classrooms. For this purpose, a questionnaire was created to investigate the degree of knowledge that the experts who evaluated the different software possessed of different existing programs in the market for the production of objects in AR. Among the results obtained, it should be noted that, in the absence of studies that assess the production software of learning objects in AR, this work provides indications, both for the selection of the same, and to have criteria for its assessment. From the conclusions obtained, highlight that the work has allowed identifying the ten programs that are most known by the experts at the moments in which they are made, such as: Arlab, Armedia, Arpa, ARTTolkit, Aurasma, Blippar, Designers artoolkit, Layar, Vuforia and Wikitude
Proyecto Técnico Ecourbano apoyado en las TIC para el aprendizaje STEM (Dibujo Técnico) y la consolidación de los ODS en el aula.
Authors: Del Cerro Velázquez Francisco , Lozano Rivas Fernando 
Published: December 2019

El objetivo del presente artículo es presentar los resultados de aprendizaje con alumnos de Dibujo Técnico en primer curso de bachillerato, como consecuencia de la realización de un Proyecto Técnico Ecourbano apoyado en las TIC. A lo largo del proceso, los participantes han desarrollado competencias descritas en la LOMCE tales como el fomento de la creatividad, el pensamiento crítico, el uso de las TIC en el aula y han puesto en valor los Objetivos de Desarrollo Sostenible (ODS), trabajando los contenidos establecidos en el decreto curricular tales como geometría plana, croquización y sistemas de representación. Mediante un método cuantitativo experimental, la investigación muestra resultados que evidencian una mejora significativa tanto en la motivación como en el aprendizaje de los alumnos en el área. La experiencia ha permitido comparar el rendimiento académico de los alumnos que participaron en el proyecto frente al resto, evidenciando una mejora notable de los primeros en sus calificaciones a finales de curso y, por tanto, ha posibilitado considerar la potencialidad del proyecto técnico ecourbano como medio de aprendizaje e instrumento de evaluación en el área de Dibujo Técnico.
The aim of this article is to present the learning results with Technical Drawing students in the first year of high school, as a consequence of the realization of an Ecourban Technical Project supported by ICT. Throughout the process, the participants have developed skills described in the LOMCE such as the promotion of creativity, critical thinking, the use of ICT in the classroom and have valued the Sustainable Development Goals (SDG), working the contents established in the curricular decree such as flat geometry, croquización and systems of representation. Using an experimental quantitative method, the research shows results that evidence a significant improvement in both the motivation and learning of students in the area. The experience has made it possible to compare the academic performance of the students who participated in the project with the rest, evidencing a notable improvement of the former in their grades at the end of the year and, therefore, has made it possible to consider the potential of the ecourban technical project as a means of learning and an evaluation instrument in the area of Technical Drawing
Successful Transcatheter PDA Device Closure in an Adult with Retrograde Wiring and Antegrade Snaring Approach
Authors: Gupta Aditya , Singh Gurkirat , Patil Vishal , Singla Rahul , Jain Akshat , Omprakash Bansal Narendra 
Published: December 2019

Patent ductus arteriosus accounts for 5 – 10% of all congenital heart disease in children. Currently, transcatheter closure is standard of care. Device closure in PDA is usually done by an antegrade technique where PDA is crossed from the PA side. In some patients, this universal procedure may not be successful due to anatomical differences. In such patients, the retrograde technique with retrograde wiring and antegrade snaring approach followed by PDA device closure may be used successfully to close PDA. We report such a case of difficult PDA device closure where the antegrade technique was not successful and PDA device closure was completed by retrograde approach.
Psychological Morbidity among Psychoactive Substance Users in a Rehabilitation Centre in Nigeria
Authors: Mobolaji Usman Dada , Rahman Lawal , Jude Ohaeri , Lateef Oluwole , Adetunji Obadeji , Ferdinand Kumolalo 
Published: December 2019

Aim: The aim of this study was to determine the prevalence and correlates of anxiety and depression among psychoactive substance users in a rehabilitation centre.
Place and Duration of Study: The study was carried out in a rehabilitation centre in Lagos state, Nigeria.
Methodology: All the inhabitants of the centre who agreed to participate in the study were included in the study. However, individuals who had stayed at the centre for less than a week were excluded from the study because the effect of use or withdrawal effects of some of the drugs may mimic depressive or anxiety symptoms. The 9-item Patient Health Questionnaire (PHQ-9) and the Mini International Neuropsychiatric Interview (M.I.N.I) (anxiety modules) were used to asses for depression and anxiety disorder respectively.
Results: A total of seventy six people participated in this study. Their ages ranged from 17 to 52 years (mean= 25.9 years SD= 8.4). A high number of the subjects were males (72.4%), single (78.7%) and unemployed (64.5%). Almost all the subjects (92.1%) were introduced to the use of psychoactive substances by friends/peers. Only 4 (5.3%) subjects reported injection drug use (IDU). 53.9% of the subjects had an anxiety disorder. While 68.4% had depression. The factors associated with having anxiety disorder were female sex, older age, being divorced/ separated/widowed, unemployment, multiple substance use, long duration of use of alcohol, cocaine and heroin.
Factors associated with depression included; young age of onset of substance use, female sex, being separated or divorced or widowed, unemployment, long duration/ frequency of use of substances and multiple substance use.
Conclusion: This study has shown that there is a high rate of anxiety and depression among psychoactive substance users.
Pfcrt K76T and Pfmdr 1 Resistance Genes in Post Chloroquine Era in South-South Region of Nigeria
Authors: Alade Tolulope , Sunday Itodo Ewaoche , Lawani Ebidor , Adie Gloria , Youtchou Tatfeng Mirabeau 
Published: December 2019

Malaria, a global health problem especially in the sub-Sahara region has been posing a recurrent problem due to the resistance of the parasites to the available antimalarial drugs despite the preventive measures provided by WHO.
Aims: This study is aimed at determining the prevalence of resistance markers in four Niger Delta states of Nigeria, a decade after withdrawal of chloroquine.
Methods: Eight hundred and forty six (846) subjects participated in the study and were distributed as follows, 192(22.7%) Bayelsa; 218(25.8%) Rivers; 196(23.2%) Edo and 240(28.4%) Delta respectively. Malaria parasite identification was carried out using standard parasitological techniques. Genotyping of the resistance markers Pfcrt K76T and Pfmdr 1 was carried out by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
Results: Our findings revealed that the prevalence of malaria infection in the four Niger Delta states were 78.1%, 68.8%, 62.8% and 58.8% in Bayelsa, Rivers States, Edo and Delta respectively. There was no statistical difference in the prevalence of malaria within the four Niger Delta states. (P>0.05). Children below the age of 5 years recorded the highest infection rates when compared to subjects in other age groups (P< 0.01). Our findings also revealed that the distribution of mutant Pfcrt K76T and Pfmdr 1 genes across the four states were 12.0% and 28.6%, 4.0% and 22.0%, 14.6% and 29.3%, 10.6% and 25.0% in Bayelsa, Rivers, Edo and Delta state respectively. However, the prevalence of Pfcrt K76T in Rivers State was statistically lower when compared to other states (P < 0.01) while no statistical difference existed in the distribution of Pfmdr 1 mutant genes (P>0.01).
Conclusion: Prevalence of Pfcrt and Pfmdr 1 remained elevated in the Niger Delta states despite the withdrawal of chloroquine over a decade ago. Hence, Nigeria is far from an eventual re-introduction of chloroquine as its resistance markers still persist in our communities. Furthermore, the root cause of the persistence of these resistance markers needs to be investigated.
Brachypodium distachyon triphosphate tunnel metalloenzyme 3 is both a triphosphatase and an adenylyl cyclase upregulated by mechanical wounding
Authors: Świeżawska Brygida , Duszyn Maria , Kwiatkowski Mateusz , Jaworski Krzysztof , Pawełek Agnieszka , Szmidt‐Jaworska Adriana 
Published: December 2019

Proteins with a CyaB, thiamine triphosphatase domain (CYTH domain) may play a central role at the interface between nucleotide and polyphosphate metabolism. One of the plant CYTH domain‐containing proteins from Brachypodium distachyon, BdTTM3, is annotated in NCBI databases as an ‘adenylyl cyclase (AC)’ or a ‘triphosphate tunnel metalloenzyme’. The divergent nomenclature and the search for plant ACs induced us to experimentally confirm the enzymatic activity of BdTTM3. Based on in vitro analysis, we have shown that the recombinant form of BdTTM3 is a protein with high triphosphatase activity (binding both tripolyphosphate and ATP) and low AC activity. Furthermore, the analysis of BdTTM3 transcriptional activity indicates its involvement in the mechanism underlying responses to wounding stress in B. distachyon leaves.
Mucin adsorbed by E. coli can affect neutrophil activation in vitro
Authors: Mikhalchik Elena , Balabushevich Nadezhda , Vakhrusheva Tatiana , Sokolov Alexey , Baykova Julia , Rakitina Daria , Scherbakov Petr , Gusev Sergey , Gusev Alexander , Kharaeva Zaira , Bukato Olga , Pobeguts Olga 
Published: December 2019

Bacteria colonizing human intestine adhere to the gut mucosa and avoid the innate immune system. We previously demonstrated that Escherichia coli isolates can adsorb mucin from a diluted solution in vitro. Here, we evaluated the effect of mucin adsorption by E. coli cells on neutrophil activation in vitro. Activation was evaluated based on the detection of reactive oxygen species production by a chemiluminescent reaction (ChL), observation of morphological alterations in neutrophils and detection of exocytosis of myeloperoxidase and lactoferrin. We report that mucin adsorbed by cells of SharL1 isolate from Crohn's disease patient's inflamed ileum suppressed the potential for the activation of neutrophils in whole blood. Also, the binding of plasma complement proteins and immunoglobulins to the bacteria was reduced. Desialylated mucin, despite having the same adsorption efficiency to bacteria, had no effect on the blood ChL response. The effect of mucin suggests that it shields epitopes that interact with neutrophils and plasma proteins on the bacterial outer membrane. Potential candidates for these epitopes were identified among the proteins within the bacterial outer membrane fraction by 2D‐PAGE, fluorescent mucin binding on a blot and HPLC‐MS/MS. In vitro, the following proteins demonstrated mucin adsorption: outer membrane porins (OmpA, OmpC, OmpD and OmpF), adhesin OmpX, the membrane assembly factor OmpW, cobalamine transporter, ferrum uptake protein and the elongation factor Ef Tu‐1. In addition to their other functions, these proteins are known to be bacterial surface antigens. Therefore, the shielding of epitopes by mucin may affect the dynamics and intensity of an immune response.
APP‐derived peptides reflect neurodegeneration in frontotemporal dementia
Authors: Illán‐Gala Ignacio , Pegueroles Jordi , Montal Victor , Alcolea Daniel , Vilaplana Eduard , Bejanin Alexandre , Borrego‐Écija Sergi , Sampedro Frederic , Subirana Andrea , Sánchez‐Saudinós María‐Belén , Rojas‐García Ricard , Vanderstichele Hugo , Blesa Rafael , Clarimón Jordi , Antonell Anna , Lladó Albert , Sánchez‐Valle Raquel , Fortea Juan , Lleó Alberto 
Published: December 2019

AbstractObjectiveWe aimed to investigate the relationship between cerebrospinal fluid levels (CSF) of amyloid precursor protein (APP)‐derived peptides related to the amyloidogenic pathway, cortical thickness, neuropsychological performance, and cortical gene expression profiles in frontotemporal lobar degeneration (FTLD)‐related syndromes, Alzheimer’s disease (AD), and healthy controls.MethodsWe included 214 participants with CSF available recruited at two centers: 93 with FTLD‐related syndromes, 57 patients with AD, and 64 healthy controls. CSF levels of amyloid β (Aβ)1‐42, Aβ1‐40, Aβ1‐38, and soluble β fragment of APP (sAPPβ) were centrally analyzed. We compared CSF levels of APP‐derived peptides between groups and, we studied the correlation between CSF biomarkers, cortical thickness, and domain‐specific cognitive composites in each group. Then, we explored the relationship between cortical thickness, CSF levels of APP‐derived peptides, and regional gene expression profile using a brain‐wide regional gene expression data in combination with gene set enrichment analysis.ResultsThe CSF levels of Aβ1‐40, Aβ1‐38, and sAPPβ were lower in the FTLD‐related syndromes group than in the AD and healthy controls group. CSF levels of all APP‐derived peptides showed a positive correlation with cortical thickness and the executive cognitive composite in the FTLD‐related syndromes group but not in the healthy control or AD groups. In the cortical regions where we observed a significant association between cortical thickness and CSF levels of APP‐derived peptides, we found a reduced expression of genes related to synaptic function.InterpretationAPP‐derived peptides in CSF may reflect FTLD‐related neurodegeneration. This observation has important implications as Aβ1‐42 levels are considered an indirect biomarker of cerebral amyloidosis.
Outcome Measures in Large Vessel Vasculitis: Relationship Between Patient‐, Physician‐, Imaging‐, and Laboratory‐Based Assessments
Authors: Rimland Casey A. , Quinn Kaitlin A. , Rosenblum Joel S. , Schwartz Mollie N. , Bates Gribbons K. , Novakovich Elaine , Sreih Antoine G. , Merkel Peter A. , Ahlman Mark A. , Grayson Peter C. 
Published: December 2019

ObjectiveTo assess the relationship between measures of disease assessment in patients with large vessel vasculitis.MethodsPatients with giant cell arteritis (GCA) or Takayasu arteritis (TAK) were recruited into a prospective, observational cohort. Assessments within the following outcomes were independently recorded: 1) patient‐reported outcomes (Multidimensional Fatigue Inventory, patient global assessment of disease activity [PtGA], Short Form 36 health survey [SF‐36], Brief Illness Perception Questionnaire), 2) physician global assessment of disease activity (PhGA), 3) laboratory outcomes (C‐reactive protein [CRP] level, erythrocyte sedimentation rate [ESR]), and 4) imaging outcomes (PETVAS, a qualitative score of vascular 18F‐fluorodeoxyglucose–positron emission tomography activity).ResultsAnalyses were performed on 112 patients (GCA = 56, TAK = 56), over 296 visits, with a median follow‐up of 6 months. Correlation network analysis revealed assessment measures clustered independently by type of outcome. PhGA was centrally linked to all other outcome types, but correlations were modest (ρ = 0.12–0.32; P < 0.05). PETVAS, CRP level, and PtGA were independently associated with clinically active disease. All 4 patient‐reported outcomes strongly correlated with each other (ρ = 0.35–0.60; P < 0.0001). Patient‐reported outcomes were not correlated with PETVAS, and only PtGA correlated with CRP level (ρ = 0.16; P < 0.01). Patients whose clinical assessment changed from active disease to remission (n = 29) had a corresponding significant decrease in ESR, CRP level, and PETVAS at the remission visit. Patients whose clinical assessment changed from remission to active disease (n = 11) had a corresponding significant increase in CRP level and PtGA at the active visit.ConclusionMeasures of disease assessment in large vessel vasculitis consist of independent, yet complementary, outcomes, supporting the need to develop composite outcome measures or a standard set of measures covering multiple types of outcomes.
Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids
Authors: Ghaffari Roozbeh , Choi Jungil , Raj Milan S. , Chen Shulin , Lee Stephen P. , Reeder Jonathan T. , Aranyosi Alexander J. , Leech Adam , Li Weihua , Schon Stephanie , Model Jeffrey B. , Rogers John A. 
Published: December 2019

AbstractWearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin‐interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real‐time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully‐integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real‐time physiological insights.
Engineered Nanoplatelets for Targeted Delivery of Plasminogen Activators to Reverse Thrombus in Multiple Mouse Thrombosis Models
Authors: Xu Junchao , Zhang Yinlong , Xu Jiaqi , Liu Guangna , Di Chunzhi , Zhao Xiao , Li Xiang , Li Yao , Pang Ningbo , Yang Chengzhi , Li Yanyi , Li Bozhao , Lu Zefang , Wang Meifang , Dai Kesheng , Yan Rong , Li Suping , Nie Guangjun 
Published: December 2019

AbstractRapid cut‐off of blood supply in diseases involving thrombosis is a major cause of morbidity and mortality worldwide. However, the current thrombolysis strategies offer limited results due to the therapeutics' short half‐lives, low targeting ability, and unexpected bleeding complications. Inspired by the innate roles of platelets in hemostasis and pathological thrombus, platelet membrane‐camouflaged polymeric nanoparticles (nanoplatelets) are developed for targeting delivery of the thrombolytic drug, recombinant tissue plasminogen activator (rt‐PA), to local thrombus sites. The tailor‐designed nanoplatelets efficiently accumulate at the thrombi in pulmonary embolism and mesenteric arterial thrombosis model mice, eliciting a significantly enhanced thrombolysis activity compared to free rt‐PA. In addition, the nanoplatelets exhibit improved therapeutic efficacy over free rt‐PA in an ischemic stroke model. Analysis of in vivo coagulation indicators suggests the nanoplatelets might possess a low risk of bleeding complications. The hybrid biomimetic nanoplatelets described offer a promising solution to improve the efficacy and reduce the bleeding risk of thrombolytic therapy in a broad spectrum of thrombosis diseases.
A Morphologically Engineered Robust Bifunctional CuCo2O4 Nanosheet Catalyst for Highly Efficient Overall Water Splitting
Authors: Aqueel Ahmed Abu Talha , Pawar Sambhaji M. , Inamdar Akbar I. , Kim Hyungsang , Im Hyunsik 
Published: December 2019

AbstractThe development of an earth abundant, low‐cost, and energy‐efficient electrocatalyst with robust adhesion is highly essential for the generation of hydrogen fuel. Herein, the outstanding overall water splitting performance of a CuCo2O4 catalyst which is fabricated using a hydrothermal process is reported. The performance optimization is done through engineering the surface structure and size of the CuCo2O4 catalyst, without altering its chemical composition and crystallinity. Different solvents used in the hydrothermal growth tune the morphology of CuCo2O4 from porous 2‐dimensional nanosheets through cubes and grains to agglomerated spheres. An optimized 2‐dimensional nanosheet CuCo2O4 catalyst exhibits superior electrochemical performance for both hydrogen evolution reaction and oxygen evolution reaction, achieving the smallest overpotential of 115 and 290 mV versus a reversible hydrogen electrode, respectively, at 10 mA cm−2 with excellent long‐term stability under an alkaline electrolyte medium (1.0 m KOH). This highly stable and electrochemically active bifunctional electrocatalyst can deliver a cell voltage of 1.64 V at 10 mA cm−2 under alkaline condition. Moreover, the correlation between electrochemical catalytic activity with solvent viscosity is manifested in the present study, which reveals that a change in morphologies causes the catalytically active surface area to vary and influences the intrinsic reaction kinetics.
Graphene Electromechanical Water Sensor: The Wetristor
Authors: Meireles Leonel M. , Neto Eliel G. S. , Ferrari Gustavo A. , Neves Paulo A. A. , Gadelha Andreij C. , Silvestre Ive , Taniguchi Takashi , Watanabe Kenji , Chacham Helio , Neves Bernardo R. A. , Campos Leonardo C. , Lacerda Rodrigo G. 
Published: December 2019

AbstractA water‐induced electromechanical response in suspended graphene atop a microfluidic channel is reported. The graphene membrane resistivity rapidly decreases to ≈25% upon water injection into the channel, defining a sensitive “channel wetting” device—a wetristor. The physical mechanism of the wetristor operation is investigated using two graphene membrane geometries, either uncovered or covered by an inert and rigid lid (hexagonal boron nitride multilayer or poly(methyl methacrylate) film). The wetristor effect, namely the water‐induced resistivity collapse, occurs in uncovered devices only. Atomic force microscopy and Raman spectroscopy indicate substantial morphology changes of graphene membranes in such devices, while covered membranes suffer no changes, upon channel water filling. The results suggest an electromechanical nature for the wetristor effect, where the resistivity reduction is caused by unwrinkling of the graphene membrane through channel filling, with an eventual direct doping caused by water being of much smaller magnitude, if any. The wetristor device should find useful sensing applications in general micro‐ and nanofluidics.