bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a gait-dependent model predict wear on retrieved total knee arthroplasty components?
Authors: Knowlton Christopher B. , Lundberg Hannah J. , Wimmer Markus A. , Jacobs Joshua J. 
Published: May 2020

AimsA retrospective longitudinal study was conducted to compare directly volumetric wear of retrieved polyethylene inserts to predicted volumetric wear modelled from individual gait mechanics of total knee arthroplasty (TKA) patients.MethodsIn total, 11 retrieved polyethylene tibial inserts were matched with gait analysis testing performed on those patients. Volumetric wear on the articular surfaces was measured using a laser coordinate measure machine and autonomous reconstruction. Knee kinematics and kinetics from individual gait trials drove computational models to calculate medial and lateral tibiofemoral contact paths and forces. Sliding distance along the contact path, normal forces and implantation time were used as inputs to Archard’s equation of wear to predict volumetric wear from gait mechanics. Measured and modelled wear were compared for each component.ResultsVolumetric wear rates on eight non-delaminated components measured 15.9 mm3/year (standard error (SE) ± 7.7) on the total part, 11.4 mm3/year (SE ± 6.4) on the medial side and 4.4 (SE ± 2.6) mm3/year on the lateral side. Volumetric wear rates modelled from patient gait mechanics predicted 16.4 mm3/year (SE 2.4) on the total part, 11.7 mm3/year (SE 2.1) on the medial side and 4.7 mm3/year (SE 0.4) on the lateral side. Measured and modelled wear volumes correlated significantly on the total part (p = 0.017) and the medial side (p = 0.012) but not on the lateral side (p = 0.154).ConclusionIn the absence of delamination, patient-specific knee mechanics during gait directly affect wear of the tibial component in TKA. Cite this article: Bone Joint J 2020;102-B(6 Supple A):129–137.
Local delivery of tobramycin and vancomycin in primary total knee arthroplasty achieves minimum inhibitory concentrations for common bacteria causing acute prosthetic joint infection
Authors: Lawrie Charles M. , Jo Sally , Barrack Toby , Roper Stephen , Wright Rick W. , Nunley Ryan M. , Barrack Robert L. 
Published: May 2020

AimsThe aim of this study was to determine if the local delivery of vancomycin and tobramycin in primary total knee arthroplasty (TKA) can achieve intra-articular concentrations exceeding the minimum inhibitory concentration thresholds for bacteria causing acute prosthetic joint infection (PJI).MethodsUsing a retrospective single-institution database of all primary TKAs performed between January 1 2014 and May 7 2019, we identified patients with acute PJI that were managed surgically within 90 days of the initial procedure. The organisms from positive cultures obtained at the time of revision were tested for susceptibility to gentamicin, tobramycin, and vancomycin. A prospective study was then performed to determine the intra-articular antibiotic concentration on postoperative day one after primary TKA using one of five local antibiotic delivery strategies with tobramycin and/or vancomycin mixed into the polymethylmethacrylate (PMMA) or vancomycin powder.ResultsA total of 19 patients with acute PJI after TKA were identified and 29 unique bacterial isolates were recovered. The mean time to revision was 37 days (6 to 84). Nine isolates (31%) were resistant to gentamicin, ten (34%) were resistant to tobramycin, and seven (24%) were resistant to vancomycin. Excluding one Fusobacterium nucleatum, which was resistant to all three antibiotics, all isolates resistant to tobramycin or gentamicin were susceptible to vancomycin and vice versa. Overall, 2.4 g of tobramycin hand-mixed into 80 g of PMMA and 1 g of intra-articular vancomycin powder consistently achieved concentrations above the minimum inhibitory concentrations of susceptible organisms.ConclusionOne-third of bacteria causing acute PJI after primary TKA were resistant to the aminoglycosides commonly mixed into PMMA, and one-quarter were resistant to vancomycin. With one exception, all bacteria resistant to tobramycin were susceptible to vancomycin and vice versa. Based on these results, the optimal cover for organisms causing most cases of acute PJI after TKA can be achieved with a combination of tobramycin mixed in antibiotic cement, and vancomycin powder. Cite this article: Bone Joint J 2020;102-B(6 Supple A):163–169.
Preoperative cut-off values for body mass index deny patients clinically significant improvements in patient-reported outcomes after total hip arthroplasty
Authors:   Cleveland Clinic OME Arthroplasty Group, Arnold Nicholas , Anis Hiba , Barsoum Wael K. , Bloomfield Michael R. , Brooks Peter J. , Higuera Carlos A. , Kamath Atul F. , Klika Alison , Krebs Viktor E. , Mesko Nathan W. , Molloy Robert M. , Mont Michael A. , Murray Trevor G. , Patel Preteesh D. , Strnad Gregory , Stearns Kim L. , Warren Jared , Zajichek Alexander , Piuzzi Nicolas S. 
Published: May 2020

AimsThresholds for operative eligibility based on body mass index (BMI) alone may restrict patient access to the benefits of arthroplasty. The purpose of this study was to evaluate the relationship between BMI and improvements in patient-reported outcome measures (PROMs), and to determine how many patients would have been denied improvements in PROMs if BMI cut-offs were to be implemented.MethodsA prospective cohort of 3,449 primary total hip arthroplasties (THAs) performed between 2015 and 2018 were analyzed. The following one-year PROMs were evaluated: hip injury and osteoarthritis outcome score (HOOS) pain, HOOS Physical Function Shortform (PS), University of California, Los Angeles (UCLA) activity, Veterans Rand-12 Physical Component Score (VR-12 PCS), and VR-12 Mental Component Score (VR-12 MCS). Positive predictive values for failure to improve and the number of patients denied surgery in order to avoid a failed improvement were calculated for each PROM at different BMI cut-offs.ResultsThere was a trend to improved outcomes in terms of pain and function improvements with higher BMI. Patients with BMI ≥ 40 kg/m2had median (Q1, Q3) HOOS pain improvements of 58 points (interquartile range (IQR) 41 to 70) and those with BMI 35 to 40 kg/m2had median improvements of 55 (IQR 40 to 68). With a BMI cut-off of 30 kg/m2, 21 patients would have been denied a meaningful improvement in HOOS pain score in order to avoid one failed improvement. At a 35 kg/m2cut-off, 18 patients would be denied improvement, at a 40 kg/m2cut-off 21 patients would be denied improvement, and at a 45 kg/m2cut-off 21 patients would be denied improvement. Similar findings were observed for HOOS-PS, UCLA, and VR-12 scores.ConclusionPatients with higher BMIs show greater improvements in PROMs. Using BMI alone to determine eligibility criteria did not improve the rate of clinically meaningful improvements. BMI thresholds prevent patients who may benefit the most from surgery from undergoing THA. Surgeons should consider PROMs improvements in determining eligibility for THA while balancing traditional metrics of preoperative risk stratification. Cite this article: Bone Joint J 2020;102-B(6):683–692.
Saline lavage after a “dry tap”
Authors: Heckmann Nathanael D. , Nahhas Cindy R. , Yang JaeWon , Della Valle Craig J. , Yi Paul H. , Culvern Chris N. , Gerlinger Tad L. , Nam Denis 
Published: May 2020

Aims In patients with a “dry” aspiration during the investigation of prosthetic joint infection (PJI), saline lavage is commonly used to obtain a sample for analysis. The aim of this study was to investigate prospectively the impact of saline lavage on synovial fluid analysis in revision arthroplasty. Methods Patients undergoing revision hip (THA) or knee arthroplasty (TKA) for any septic or aseptic indication were enrolled. Intraoperatively, prior to arthrotomy, the maximum amount of fluid possible was aspirated to simulate a dry tap (pre-lavage) followed by the injection with 20 ml of normal saline and re-aspiration (post-lavage). Pre- and post-lavage synovial white blood cell (WBC) count, percent polymorphonuclear cells (%PMN), and cultures were compared. Results A total of 78 patients had data available for analysis; 17 underwent revision THA and 61 underwent revision TKA. A total of 16 patients met modified Musculoskeletal Infection Society (MSIS) criteria for PJI. Pre- and post-lavage %PMNs were similar in septic patients (87% vs 85%) and aseptic patients (35% vs 39%). Pre- and post-lavage synovial fluid WBC count were far more disparate in septic (53,553 vs 8,275 WBCs) and aseptic (1,103 vs 268 WBCs) cohorts. At a cutoff of 80% PMN, the post-lavage aspirate had a sensitivity of 75% and specificity of 95%. At a cutoff of 3,000 WBCs, the post-lavage aspirate had a sensitivity of 63% and specificity of 98%. As the post-lavage synovial WBC count increased, the difference between pre- and post-lavage %PMN decreased (mean difference of 5% PMN in WBC < 3,000 vs mean difference 2% PMN in WBC > 3,000, p = 0.013). Of ten positive pre-lavage fluid cultures, only six remained positive post-lavage. Conclusion While saline lavage aspiration significantly lowered the synovial WBC count, the %PMN remained similar, particularly at WBC counts of > 3,000. These findings suggest that in patients with a dry-tap, the %PMN of a saline lavage aspiration has reasonable sensitivity (75%) for the detection of PJI. Cite this article: Bone Joint J 2020;102-B(6 Supple A):138–144.
Control of Diesel-electric AC/DC Traction Drive of Motor Truck WŽB 10.1-M
Authors: Mašek Zdeněk , Novák Jaroslav , Sadílek Ondřej , Lelek Tomáš 
Published: June 2020

The paper describes the control of traction drive and control systems properties of a special rail vehicle WŽB10.1-M used in the Prague metro (subway). Measured values of main quantities of the control system and experience from duty are included. Software for the traction drive control system was developed at the University of Pardubice.
Diabetes mellitus in patients with rheumatoid arthritis in the Republic of Karelia
Authors: Koryakova N. V. , Polskaya I. I. , Marusenko I. M. , Kulagina T. I. 
Published: May 2020

Objective: to estimate the incidence of diabetes mellitus (DM) in patients with rheumatoid arthritis (RA) in the Republic of Karelia and to analyze the types of carbohydrate metabolism disorders.Patients and methods. The investigation enrolled 889 patients aged 18 years and older with RA treated in the Rheumatology Department, V.A. Baranov Republican Hospital (Petrozavodsk), in 2000 to 2019. Among them, there were 709 (79.8%) women and 180 (20.2%) men; the median age was 59 [52; 66] years; the median duration of RA was 6.5 [1.75; 13] years. Most patients were found to have positive rheumatoid factor (68.3%), the second and more advanced radiological stages (90.6%), and moderate and high RA disease activity (84.8%). Methotrexate as a mainstay disease-modifying anti-rheumatic drug was taken by 68.2%; biological agents and glucocorticoids (GCs) were used in 4.8 and 3.3%, respectively. The incidence of DM and its types and risk factors (RFs) were analyzed.Results and discussion. DM was recorded in 67 (7.5%) RA patients (55 women and 12 men; the median age was 62 [56; 66] years). Among these patients, 9 (1.0%) patients with RA were observed to have type 1 DM, 50 (5.6%) and 8 (0.9%) patients had steroid-induced DM (SIDM), and type 2 DM, respectively. In 55.5% of cases, type 1 DM was represented by latent autoimmune diabetes in adults (LADA), which is of late onset. SIDM was detected in 75% of patients over 60 years of age who had RFs for type 2 DM. In this study, the incidence of type 2 DM in RA patients exceeded official figures in the general population of the Russian Federation, but was close to the predicted prevalence rates of type 2 DM. Patients with RA and type 2 DM had major RFs, such as age over 45 years, hypertension, overweight or obesity; moreover, 60% of patients were found to have a combination of these factors.Conclusion. RA patients showed a higher incidence rate of carbohydrate disorders of different types; the number of cases of type 1 DM and type 2 DM among the examined patients with RA exceeded that in the regional DM registries in the general population in the Republic of Karelia. It seems advisable to screen for carbohydrate disorders in patients with RA, especially in the presence of RFs for type 2 DM and during systemic therapy with GCs.
Pemberdayaan Muslim Muallaf Melalui Home Industry Kerupuk Ikan Lomek di Desa Selat Akar
Authors: Masduki Masduki , Hartono Toni , Sardila Vera , Arung Triantoro Dony 
Published: May 2020

This article discusses about economic empowerment based on home industry to enforce the faith of new Muslim converters in Desa Selat Akar Kepualaun Meranti, Riau. To understand the economic potential of this village, the faith enforcement seems to be more effective when it is done through economic empowerment based on home industry. This resesearch was founded, i.e. To support this, the empowerment uses community based research concept. This research founded i.e. first, doing an evaluation during observation and conducting identification before the empowerment done. Second, this empowerment finds that this a new Muslim group needs physical capital assistance to develop its enterprises. Third, making ‘Lomek’ fish crackers has become an instrument or media among the Muallafs to keep and improve their faith. Tulisan ini mendiskusikan pemberdayaan ekonomi berbasis home industry untuk penguatan akidah Muslim Muallaf di Desa Selat Akar Kepulauan Meranti, Riau. Memahami potensi ekonomi yang ada di desa tersebut, maka penguatan akidah para Muslim Muallaf tampak menjadi lebih efektif apabila dilakukan dengan penguatan sisi ekonomi rumahan atau berbasis home industry. Untuk mendukung keberhasilan kegiatan, pemberdayaan ini menggunakan konsep Community Based Research (CBR) dengan metode kualitatif. Penelitian ini menemukan beberapa program pemberdayaan antara lain; pertama, melakukan evaluasi pada saat observasi dan identifikasi sebelum pemberdayaan dilakukan. Kedua, menemukan bahwa kelompok Muslim Muallaf memerlukan bantuan modal fisik untuk pengembangan usaha mereka. Ketiga, membuat kerupuk Ikan Lomek benar-benar telah menjadi media sekaligus wadah tempat di mana para Muslim Muallaf dapat meningkatkan dan memperkokoh akidah mereka.
Struktur Logika Teologi Islam Menurut Van Ess: Sebuah Telaah Kritis
Authors: Arif Muhammad 
Published: May 2020

Josef van Ess melalui tulisannya “The Logical Structure of Islamic Theology” menyatakan bahwa logika teologi Islam telah banyak mengadopsi logika Yunani kuno, terutama logika Stoic. Menurut penelusuran van Ess, ada banyak kesamaan mencolok antara konsep-konsep dan istilah- istilah yang digunakan dalam teologi Islam dengan logika Stoic. Tidak ayal, van Ess kemudian berkesimpulan bahwa struktur logika teologi Islam sejatinya tidak lain hanyalah derevasi dari bangunan logika Stoic. Pendapat van Ess ini tentu sangat menarik untuk dikaji. Bukankah sejarah mencatat bahwa gaya teologi Islam sejatinya telah dimulai sejak masa Nabi, jauh sebelum Islam bersentuhan dengan tradisi Yunani? Selain itu, apakah dengan mengadopsi konsep dan istilah logika Stoic, lantas bisa dikatakan bahwa struktur logika teologi Islam adalah derevatif? Bukankah konsep dan istilah itu telah digunakan dalam kultur dan konsteks yang sama sekali berbeda? Semua persoalan ini diulas secara sederhana dalam artikel ini.
Tarekat Hizib Nahdlatul Wathan Dan Perannya Dalam Perpolitikan Di Lombok
Authors: Ziadi M. Rohman 
Published: May 2020

Tarekat is a Sufi brotherhood in which it contains and practices sufistic principles. In Sufism,there is a very thick concept, namely zuhud. Zuhud is the emptiness of search, which limits his desire to gain the world. From this it can be seen that the Sufic tradition should be reluctant to desire the world, including politics. However, the Hizib Nahdlatul Wathan as a tarekat appeared to be very active in politics, even the founder and Tarekat murshid Hizib Nahdlatul Wathan became a major driver in politics in Lombok. This is interesting, on the one hand the Hizib Nahdlatul Wathan is a tarekat, but on the other hand it looks very active in the politics of Lombok. Therefore, the authors are interested in studying more about the Hizib Nahdlatul Wathan and its role in politics in Lombok. There are two problem formulations in this article, namely; what is the concept of teaching the Hizib Nahdlatul Wathan Order? What is the religious foundation of the Hizib Nahdlatul Wathan Order in its political activities in Lombok? To answer the two formulations of the problem the author uses a literature review and interview research method. In addition, the author also uses two theories to dissect the formulation of the problem, namely the tarekat theory and the tarekat and political theory of Martin van Bruinessen. The tarekat theory the author uses to answer the first problem statement. While the theory of tarekat and politics of Martin van Bruinessen, the author uses it to answer the problem statement number two.
Memaknai Ulang Wacana Waria dalam Konteks Indonesia (Analisis Hermeneutika Terhadap Novel “Perempuan Tanpa V”)
Authors: Syafi’i Muhammad 
Published: May 2020

The social construction of transvestites which has so far been still far from what is expected, transgenders in general often get stereotypes that have long taken root so that they become individuals/groups who are marginalized in society. They tend to be shunned because religion and morality are big questions due to their tendency to like same-sex. This construction is entrenched and to this day, they have not received a proper place and are made as human beings as usual. Related to this, there is a novel called "Perempuan Tanpa V" which tells of transvestites in different perspectives. Because of that the writer wants to study this novel and further find out the construction of transvestites he wants to convey. This study uses Gadamer's hermeneutics approach as an analysis knife. The definition of transvestites in this novel eventually leads to the construction of transvestites who are built more positively, are not discriminatory, and try to break the stereotype of transvestites that has been understood by the community: irregularities and immorality.
EVALUATION OF THE PRODUCTION PLANNING POLICY ALTERNATIVES IN A PET RESIN PRODUCTION PLANT: A CASE STUDY FROM TURKEY
Authors: Demirkan Abdullah Akman , Unutmaz Durmuşoğlu Zeynep Didem 
Published: June 2020

Goal: The main purpose of this work is to develop several production planning models for one of bottle grade PET production plants (in Turkey) under different scenarios by considering different levels of inventory (no stock and different levels of safety stocks), different energy sourcing alternatives (natural gas/coal or both) and production throughput (different lot sizes).
Design/Methodology/Approach: Deterministic multi-product multi-period single level mixed integer linear programming model is presented. The model is implemented for the above defined scenarios. We have also considered the total emission produced for different energy alternatives.
Results: The models for the different scenarios have shown that significant performance improvements can be achieved by changing the parameters/policies of the production. The best model obtained has yielded 6.6% of profit improvement and 6.9% of cost reduction.
Limitations of the investigation: Planning horizon of this work could cover the data of years 2014 to 2018. However, the actual data employed for this study is limited with one year due to unavailability of further data. In addition to this, improvement of current production planning approach of the plant by implementation of proposed model is one of the objectives of this study to see success rate of model. Though, this couldn’t be realized. We hypothetically tested the improvement provided by the proposed model, therefore we can’t analyze the actual improvement.
Practical implications: Interactions among optimal results obtained by running model with different scenarios and their effect on selected performance variables are the main contribution of this work. Similar methodology could be used at other PET resin manufacturing plants or alternatively the production facilities having similar type of continuous manufacturing processes to find their optimal levels of inventory, production throughput and proper choice for energy sourcing alternative.
Originality/Value: The research on the production planning for PET resin industry by considering the different scenarios (levels of inventory / energy sourcing alternatives/ production throughput) is novel as far as we know, and therefore the approach used in this study is expected to be useful for other similar plants.
Kandungan Senyawa Beta Karoten pada Spirulina platensis dengan Perlakuan Perbedaan Lama Waktu Pencahayaan
Authors: Hanani Triana , Widowati Ita , Susanto AB 
Published: June 2020

Spirulina platensis merupakan salah satu mikroalga yang mengandung pigmen beta karoten. Beta karoten memiliki manfaat sebagai antioksidan dan antikanker. Pertumbuhan mikroalga dipengaruhi oleh berbagai macam faktor lingkungan, salah satunya adalah cahaya. Penelitian ini bertujuan untuk menentukan lama waktu pencahayaan yang baik untuk mengoptimalkan pertumbuhan dan produksi pigmen beta karoten pada S. platensis.Metode yang digunakan adalah eksperimen laboratoris. Mikroalga S. platensis dikultivasi dengan dua perlakuan lama waktu pencahayaan yang berbeda yaitu A: 24 jam Terang dan 0 jam Gelap (24T,0G); dan B: 12 jam Terang dan 12 jam Gelap (12T, 12G). Pertumbuhan sel S. platensis diamati selama 11x24 jam kemudian dipanen. Biomassa basah hasil kultivasi dikeringkan agar mendapat biomassa kering yang akan diekstraksi menggunakan pelarut n-heksana. Ekstrak n-heksana S. platensis kemudian dianalisis kandungan pigmen beta karotennya secara spektrofotometrik.Hasil penelitian menunjukkan bahwa perlakuan perbedaan lama waktu pencahayaan tidakberpengaruh secara nyata terhadap pertumbuhan sel dan kandungan pigmen beta karoten pada S. platensis. Pertumbuhan sel S. platensis dan kandungan beta karoten tertinggi dihasilkan oleh S. platensis yang dikultur pada pencahayaan 24 Terang dan 0 jam gelap (perlakuan A), yaitu berturut-turut 177,62 x 103 sel/mldan0,00183 µg/g. Spirulina platensis is a microalga containing beta carotene pigment. Beta carotene has the benefit of being antioxidants and anticancer. Various environmental factors influence microalgae growth; one of them is light. The purpose of this research is to determine the best lighting duration to optimize the growth and production of beta carotene pigments in S. platensis. The method used in this research was a laboratory experiment. S. platensis was cultivated with two different lighting duration treatments, i.e.A: 24 hours light, 0-hour dark (24T, 0G), and B: 12 hours light, 12 hours dark (12T, 12G). The growth of S. platensis was observed for 11x24 hours and then harvested. The biomass of S. plantesis was then dried and extracted using n-hexane and analyzed for its beta carotene pigment content spectrophotometrically. The result showed that lighting duration treatment had an insignificant effect on cell growth and beta carotene content ofS.platensis. The optimum growth and beta carotene concentration were optimally achieved by S. platensis cell cultivated in 24 hours light and 0 hours dark, i.e. 177,62 x 103 cell/mL, 0,00183 µg/g respectively.