bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Trypanosoma cruzi load and major cardiovascular outcomes in patients with chronic Chagas cardiomyopathy: a prospective cohort study
Authors: Echeverría Luis E. , Rojas Lyda Z. , Rueda‐Ochoa Oscar L. , Gómez‐Ochoa Sergio Alejandro , González Rugeles Clara Isabel , Díaz Martha Lucía , Marcus Rachel , Morillo Carlos A. 
Published: September 2020

AbstractObjectivesTo analyse the effect of parasite load assessed by quantitative reverse transcription PCR (RT‐qPCR) in serum on the prognosis of patients with chronic Chagas cardiomyopathy (CCM) after a 2‐year follow‐up.MethodsProspective cohort study conducted between 2015 and 2017. One hundred patients with CCM were included. Basal parasitaemia levels of Trypanosoma cruzi (T. cruzi) were measured using a quantitative polymerase chain reaction (qPCR) test. The primary composite outcome (CO) was all‐cause mortality, cardiac transplantation and implantation of a left ventricular assist device. Secondary outcomes were the baseline levels of serum biomarkers and echocardiographic variables.ResultsAfter a 2 years of follow‐up, the primary CO rate was 16%. A positive qPCR was not associated with a higher risk of the CO. However, when parasitaemia was evaluated by comparing tertiles (tertile 1: undetectable parasitaemia, tertile 2: low parasitaemia and tertile 3: high parasitaemia), a higher risk of the CO (HR 3.66; 95% CI 1.11–12.21) was evidenced in tertile 2. Moreover, patients in tertile 2 had significantly higher levels of high‐sensitivity troponin T and cystatin C and more frequently exhibited an ejection fraction <50%.ConclusionLow parasitaemia was associated with severity markers of myocardial injury and a higher risk of the composite outcome when compared with undetectable parasitaemia. This finding could be hypothetically explained by a more vigorous immune response in patients with low parasitaemia that could decrease T. cruzi load more efficiently, but be associated with increased myocardial damage. Additional studies with a larger number of patients and cytokine measurement are required to support this hypothesis.
Patterns of healthcare seeking among people reporting chronic conditions in rural sub‐Saharan Africa: findings from a population‐based study in Burkina Faso
Authors: Do Stefanie , Lohmann Julia , Brenner Stephan , Koulidiati Jean‐Louis , Souares Aurelia , Kuunibe Naasegnibe , Hamadou Saidou , Hien Hervé , Winkler Volker , De Allegri Manuela 
Published: September 2020

AbstractObjectiveNon‐communicable diseases are rapidly becoming one of the leading causes of morbidity and mortality in sub‐Saharan Africa. Yet, little is known about patterns of healthcare seeking among people with chronic conditions in these settings. We aimed to explore determinants of healthcare seeking among people who reported at least one chronic condition in rural Burkina Faso.MethodsData were drawn from a cross‐sectional population‐based survey conducted across 24 districts on 52 562 individuals from March to June 2017. We used multinomial logistic regression to assess factors associated with seeking care at a formal provider (facility‐based care) or at an informal provider (home and traditional treatment) compared to no care.Results1124 individuals (2% of all respondents) reported at least one chronic condition. Among those, 22.8% reported formal care use, 10.6% informal care use, and 66.6% no care. The presence of other household members reporting a chronic condition (RRR = 0.57, 95%‐CI [0.39, 0.82]) was negatively associated with seeking formal care. Wealthier households (RRR = 2.14, 95%‐CI [1.26, 3.64]), perceived illness severity (RRR = 3.23, 95%‐CI [2.22, 4.70]) and suffering from major chronic conditions (RRR = 1.54, 95%‐CI [1.13, 2.11]) were positively associated with seeking formal care.ConclusionOnly a minority of individuals with chronic conditions sought formal care, with important differences due to socio‐economic status. Policies and interventions aimed at increasing the availability and affordability of services for early detection and management in peripheral settings should be prioritised.
Dual‐color 3D‐dSTORM colocalization and quantification of ROXY1 and RNAPII variants throughout the transcription cycle in root meristem nuclei
Authors: Maß Lucia , Holtmannspötter Michael , Zachgo Sabine 
Published: September 2020

SUMMARYTo unravel the function of a protein of interest, it is crucial to asses to what extent it associates via direct interactions or by overlapping expression with other proteins. ROXY1, a land plant‐specific glutaredoxin, exerts a function in Arabidopsis flower development and interacts with TGA transcription factors in the nucleus. We detected a novel ROXY1 function in the root meristem. Root cells that lack chlorophyll reducing plant‐specific background problems that can hamper colocalization 3D microscopy. Thus far, a super‐resolution three‐dimensional stochastic optical reconstruction microscopy (3D‐dSTORM) approach has mainly been applied in animal studies. We established 3D‐dSTORM using the roxy1 mutant complemented with green fluorescence protein‐ROXY1 and investigated its colocalization with three distinct RNAPII isoforms. To quantify the colocalization results, 3D‐dSTORM was coupled with the coordinate‐based colocalization method. Interestingly, ROXY1 proteins colocalize with different RNA polymerase II (RNAPII) isoforms that are active at distinct transcription cycle steps. Our colocalization data provide new insights on nuclear glutaredoxin activities suggesting that ROXY1 is not only required in early transcription initiation events via interaction with transcription factors but likely also participates throughout further transcription processes until late termination steps. Furthermore, we showed the applicability of the combined approaches to detect and quantify responses to altered growth conditions, exemplified by analysis of H2O2 treatment, causing a dissociation of ROXY1 and RNAPII isoforms. We envisage that the powerful dual‐color 3D‐dSTORM/coordinate‐based colocalization combination offers plant cell biologists the opportunity to colocalize and quantify root meristem proteins at an increased, unprecedented resolution level <50 nm, which will enable the detection of novel subcellular protein associations and functions.
Evaluation of the effects of intraabdominal hypertension on equine central venous pressure
Authors: Munsterman Amelia S. , Gillen Alexandra M. , Coleridge Matthew O. D. , Hanson R. Reid 
Published: September 2020

AbstractObjectiveTo evaluate the effect of changes in intraabdominal pressure (IAP) on central venous pressure (CVP) in normal horses.DesignExperimental, in vivo study.SettingUniversity Teaching Hospital.AnimalsConvenience sample of 7 mixed breed horses—5 geldings and 2 mares.InterventionsPneumoperitoneum was induced in horses under standing sedation with carbon dioxide gas using a laparoscopic insufflator for a total of 60 minutes to simulate clinical elevation in IAP. Pressure was increased stepwise to 20 mm Hg over 30 minutes, and maintained at that pressure for 30 minutes to evaluate the effect of sustained intraabdominal hypertension. CVP was obtained from the cranial vena cava, concurrent with pressure obtained from the peritoneal cavity.Measurements and main resultsCVP increased as IAP increased up to 12 mm Hg, and declined as IAP increased further. The changes in CVP over time were significantly different (P < 0.03). Repeated measures correlation was positive, and highest, for mean CVP as IAP increased from 0 to 12 mm Hg (r = .70; 95% CI, .43–.85;P < 0.0001). Correlation of mean CVP with insufflation pressure became negative as IAP increased further from 15 to 20 mm Hg (r = –.47; 95% CI, –.66 to –.21;P = 0.0006).ConclusionsThis report provides preliminary data demonstrating a biphasic trend in equine CVP caused by changes in IAP, similar to that observed in other species. Further investigations are needed to evaluate this trend and to confirm these results in clinical patients.
Influence of peer‐derived donor recruitment on the youth perception on blood donation among college students
Authors: Al‐Riyami Arwa Z. , Draz Munther , Al‐Haddadi Fatma , Al‐Kabi Aisha , AlManthari Abdullah , Panchatcharam Sathiya Murthi , Al‐Sabti Hilal 
Published: September 2020

AbstractBackgroundDonor recruitment and retention pose an ongoing challenge to the blood banks. One approach to improve the effectiveness of recruitment strategies is to target influencing factors. A league is conducted yearly at the Sultan Qaboos University (SQU) to encourage blood donation. This study aims at assessing the youth perception towards blood donation at SQU and non‐SQU students.Study design and methodsA comprehensive voluntary survey was developed to assess perception of students attending SQU and non‐SQU colleges. Student demographics, donation experience and factors influencing donation decisions were assessed. The analysis was performed using IBM SPSS Statistics 22.0. A total of 600 college students filled the survey (43·5%; n = 261 males, 56·5%, n = 339 females). Half of the surveyed college students believed they have enough knowledge on blood donation. SQU students reported greater influence of peers (84% vs. 60·7%, P < 0·001), personal knowledge (82·3% vs. 74·7%, P = 0·029) and personal experiences (79·3% vs. 69%, P = 0·005). They also reported more commitment to the society (90·3% vs. 78%, P < 0·001) and altruism (89·3% vs. 71%, P < 0·001). SQU students reported lower rates of fear from needles (18% vs. 32%, P < 0·001) and from seeing blood (15·7% vs. 29·3%, P < 0·001).ConclusionSultan Qaboos University students reported higher rates of motivating and lower rates of discouraging factors towards blood donation. These results highlighted the positive impact and important role of the youth in promoting blood donations among themselves. Distinct promotion strategies should be adopted to increase blood donation among the youth.
Crop residue retention suppresses seedling emergence and biomass of winter and summer Australian weed species
Authors: Mobli Ahmadreza , Chauhan Bhagirath Singh 
Published: September 2020

AbstractCrop residue retention could affect the emergence and biomass of weeds in different ways. A summer and winter pot study was conducted to evaluate the effect of different amounts of sorghum and wheat residue on the emergence and biomass of 12 summer and winter Australian weeds. The equivalent amount of sorghum residue to 0, 1, 2, 4 and 6 t/ha was used in the summer study and winter weed seeds were covered with wheat residue equivalent to the amount of 0, 1, 2, 4 and 8 t/ha in the winter study. The emergence and biomass of Amaranthus retroflexus and Echinochloa colona was not affected by sorghum residue treatment. For other summer weeds, the use of the 6 t/ha sorghum residue treatment resulted in 59–94% reductions in biomass compared to no‐sorghum residue retention. Similarly, the application of 8 t/ha wheat residue in the winter study resulted in a reduced biomass of 15–100% compared to no‐crop residue treatment. The results demonstrated the high potential of using crop residues in eco‐friendly weed management strategies, such as harvest weed seed control tactics.
Removal of endosulfan in a sequencing batch reactor: addition of granular activated carbon as improvement strategy
Authors: Reynoso Varela Andrea , Vázquez Contreras Fabián P. , de los Santos Villalobos Sergio , Alvarez Valencia Luis H. , Ulloa Mercado Ruth G. , Serrano Palacios Denisse 
Published: September 2020

AbstractA granular activated carbon‐sequencing batch reactor (GAC‐SBR) was used to assess the removal of organochlorine endosulfan pesticide. The reactor operated in three stages: (I) starter and stabilization; (II) addition of 4 mg/L of endosulfan in feed; and (III) a single addition of 1 g/L of GAC to mixed liquor. During the 249 days of operation, the removal efficiency of COD was 96 ± 2%; for ‐N 72 ± 1%; and for PO4−3‐P 48 ± 13%. Was eliminated the 79% of endosulfan in stage II and 99% in stage III, not found its metabolite (endosulfan sulphate) in the reactor effluent. A consortium of eight bacterial strains was identified in the reactor stages, assessing five of them in the presence of 4 mg endosulfan/L by growth kinetics. According to the results, the joint action of the consortium and GAC addition is the responsible of eliminating the pesticide.
The effects of high altitude ascent on splenic contraction and the diving response during voluntary apnoea
Authors: Holmström Pontus K. , Bird Jordan D. , Thrall Scott F. , Kalker Ann , Herrington Brittney A. , Soriano Jan E. , Mann Leah M. , Rampuri Zahrah H. , Brutsaert Tom D. , Karlsson Øyvind , Sherpa Mingma T. , Schagatay Erika K. A. , Day Trevor A. 
Published: September 2020

New Findings

What is the central question of this study?
What is the relative contribution of a putative tonic splenic contraction to the haematological acclimatization process during high altitude ascent in native lowlanders?

What is the main finding and its importance?
Spleen volume decreased by −14.3% (−15.2 ml) per 1000 m ascent, with an attenuated apnoea‐induced [Hb] increase, attesting to a tonic splenic contraction during high altitude ascent. The [Hb]‐enhancing function of splenic contraction may contribute to restoring oxygen content early in the acclimatization process at high altitude.

AbstractVoluntary apnoea causes splenic contraction and reductions in heart rate (HR; bradycardia), and subsequent transient increases in haemoglobin concentration ([Hb]). Ascent to high altitude (HA) induces systemic hypoxia and reductions in oxygen saturation (), which may cause tonic splenic contraction, which may contribute to haematological acclimatization associated with HA ascent. We measured resting cardiorespiratory variables (HR, , [Hb]) and resting splenic volume (via ultrasound) during incremental ascent from 1400 m (day 0) to 3440 m (day 3), 4240 m (day 7) and 5160 m (day 10) in non‐acclimatized native lowlanders during assent to HA in the Nepal Himalaya. In addition, apnoea‐induced responses in HR, and splenic volume were measured before and after two separate voluntary maximal apnoeas (A1–A2) at 1400, 3440 and 4240 m. Resting spleen volume decreased −14.3% (−15.2 ml) per 1000 m with ascent, from 140 ± 41 ml (1400 m) to 108 ± 28 ml (3440 m; P > 0.99), 94 ± 22 ml (4240 m; P = 0.009) and 84 ± 28 ml (5160 m; P = 0.029), with concomitant increases in [Hb] from 125 ± 18.3 g l−1 (1400 m) to 128 ± 10.4 g l−1 (3440 m), 138.8 ± 12.7 g l−1 (4240 m) and 157.5 ± 8 g l−1 (5160 m; P = 0.021). Apnoea‐induced splenic contraction was 50 ± 15 ml (1400 m), 44 ± 17 ml (3440 m; P > 0.99) and 26 ± 8 ml (4240 m; P = 0.002), but was not consistently associated with increases in [Hb]. The apnoea‐induced bradycardia was more pronounced at 3440 m (A1: P = 0.04; A2: P = 0.094) and at 4240 m (A1: P = 0.037 A2: P = 0.006) compared to values at 1400 m. We conclude that hypoxia‐induced splenic contraction at rest (a) may contribute to restoring arterial oxygen content through its [Hb]‐enhancing contractile function and (b) eliminates further apnoea‐induced [Hb] increases in hypoxia. We suggest that tonic splenic contraction may contribute to haematological acclimatization early in HA ascent in humans.
Bursting mitral cells time the oscillatory coupling between olfactory bulb and entorhinal networks in neonatal mice
Authors: Kostka Johanna K. , Gretenkord Sabine , Spehr Marc , Hanganu‐Opatz Ileana L. 
Published: September 2020

Key points
During early postnatal development, mitral cells show either irregular bursting or non‐bursting firing patterns
Bursting mitral cells preferentially fire during theta bursts in the neonatal olfactory bulb, being locked to the theta phase
Bursting mitral cells preferentially fire during theta bursts in the neonatal lateral entorhinal cortex and are temporally related to both respiration rhythm‐ and theta phase
Bursting mitral cells act as a cellular substrate of the olfactory drive that promotes the oscillatory entrainment of entorhinal networks
AbstractShortly after birth, the olfactory system provides not only the main source of environmental inputs to blind, deaf, non‐whisking and motorically‐limited rodents, but also the drive boosting the functional entrainment of limbic circuits. However, the cellular substrate of this early communication remains largely unknown. Here, we combine in vivo and in vitro patch‐clamp and extracellular recordings to reveal the contribution of mitral cell (MC) firing to early patterns of network activity in both the neonatal olfactory bulb (OB) and the lateral entorhinal cortex (LEC), the gatekeeper of limbic circuits. We show that MCs predominantly fire either in an irregular bursting or non‐bursting pattern during discontinuous theta events in the OB. However, the temporal spike‐theta phase coupling is stronger for bursting than non‐bursting MCs. In line with the direct OB‐to‐LEC projections, both bursting and non‐bursting discharge augments during co‐ordinated patterns of entorhinal activity, albeit with higher magnitude for bursting MCs. For these neurons, temporal coupling to the discontinuous theta events in the LEC is stronger. Thus, bursting MCs might drive the entrainment of the OB–LEC network during neonatal development.
Subleading contributions to the nuclear scalar isoscalar current
Authors: Krebs H. , Epelbaum E. , Meißner U.-G. 
Published: September 2020

AbstractWe extend our recent analyses of the nuclear vector, axial-vector and pseudoscalar currents and derive the leading one-loop corrections to the two-nucleon scalar current operator in the framework of chiral effective field theory using the method of unitary transformation. We also show that the scalar current operators at zero momentum transfer are directly related to the quark mass dependence of the nuclear forces.
Resonant $$a_0(980)$$ state in triangle rescattering $$D_s^+\rightarrow \pi ^+\pi ^0\eta $$ decays
Authors: Hsiao Yu-Kuo , Yu Yao , Ke Bai-Cian 
Published: September 2020

AbstractWe study the $$D_s^+\rightarrow \pi ^+(a_0(980)^0\rightarrow )\pi ^0\eta $$

D
s
+

→

π
+

(

a
0

(
980
)

0

→
)

π
0

η

, $$\pi ^0(a_0(980)^+\rightarrow )\pi ^+\eta $$

π
0

(

a
0

(
980
)

+

→
)

π
+

η

decays, which have been recently measured by the BESIII collaboration. We propose that $$D_s^+\rightarrow \pi ^{+(0)}(a_0(980)^{0(+)}\rightarrow )\pi ^{0(+)}\eta $$

D
s
+

→

π

+
(
0
)

(

a
0

(
980
)

0
(
+
)

→
)

π

0
(
+
)

η

receives the contributions from the triangle rescattering processes, where $$M^0$$

M
0

and $$\rho ^+$$

ρ
+

in $$D_s^+\rightarrow M^0 \rho ^+$$

D
s
+

→

M
0

ρ
+

, by exchanging $$\pi ^{0(+)}$$

π

0
(
+
)

, are formed as $$a_0(980)^{0(+)}$$

a
0

(
980
)

0
(
+
)

and $$\pi ^{+(0)}$$

π

+
(
0
)

, respectively, with $$M^0=(\eta ,\eta ')$$

M
0

=

(
η
,

η
′

)

. Accordingly, we calculate that $$\mathcal{B}(D_s^+\rightarrow a_0(980)^{0(+)}\pi ^{+(0)})= (1.7\pm 0.2\pm 0.1)\times 10^{-2}$$

B

(

D
s
+

→

a
0

(
980
)

0
(
+
)

π

+
(
0
)

)

=

(
1.7
±
0.2
±
0.1
)

×

10

-
2

and $$\mathcal{B}(D_s^+\rightarrow \pi ^{+(0)}(a_0(980)^{0(+)}\rightarrow )\pi ^{0(+)}\eta ) =(1.4\pm 0.1\pm 0.1)\times 10^{-2}$$

B

(

D
s
+

→

π

+
(
0
)

(

a
0

(
980
)

0
(
+
)

→
)

π

0
(
+
)

η
)

=

(
1.4
±
0.1
±
0.1
)

×

10

-
2

, being consistent with the data.
Linguistic and Cultural Asymmetry in Translation from and into Minor Languages
Authors: Klaudy Kinga 
Published: September 2020

The aim of the paper is to extend the asymmetry hypothesis (AH) to include cultural asymmetry between translation from a major into a minor language and vica versa, and to relate the AH to the domestication/foreignization dichotomy (Venuti 2005). In this paper the “minor” language is Hungarian in comparison with Russian and English as “major” languages. The asymmetry hypothesis (Klaudy 2001, 2009) assumes that explicitation and implicitation are not symmetric strategies, as translators, if they have a choice, tend to use the operations involving explicitation rather than operations involving implicitation. The paper concludes that domestication and foreignization are also asymmetric operations; while translators prefer explicitation on the linguistic level, on the cultural level translators seem to prefer domestication.
Bruno, não Franz: a primeira onda da recepção de Ficção Completa do polonês Bruno Schulz
Authors: Borowski Gabriel 
Published: September 2020

O presente artigo propõe uma análise detalhada dos primeiros momentos da recepção de Ficção Completa (Cosac Naify, 2012), do escritor polonês Bruno Schulz (1892-1942), que constitui a primeira edição da totalidade da obra ficcional do autor em língua portuguesa. Por meio de um estudo das circunstâncias da sua publicação e das primeiras repercussões críticas, este trabalho visa lançar uma luz sobre o processo da construção da imagem doautor traduzido na cultura de chegada, com uma ênfase particular na função dos contextos preexistentes enquanto componentes de um quadro receptivo mais complexo. O ensaio sublinha também a importância do tradutor enquanto expert e orientador, ou seja, um agente ativo no processo de recepção.
Negociações na tradução de “Il Mattino”, de G. Parini
Authors: Szylit Diana Rosenthal 
Published: September 2020

Pretendemos, no presente trabalho, apresentar uma sugestão de tradução comentada de um trecho da poesia narrativa italiana Il Giorno, de Giuseppe Parini, mais especificamente da primeira parte da obra, “Il Mattino”1. Antes, porém, apresentaremos uma breve introdução sobre a obra e o autor, destacando características que, a nosso ver, são fundamentais para nortear as escolhas lexicais, sintáticas e semânticas inerentes ao ato de traduzir. Com o apoio de teóricos da tradução como Britto (1999), Eco (2010), Faleiros (2012), Paes (apud Faleiros, 2012), Schleiermacher (2009), Venuti (2002) e Vermeer (2006), esperamos apresentar uma tradução fiel ao objetivo que nos propomos, qual seja, uma versão em língua portuguesa, destinada a estudantes e acadêmicos brasileiros da área da italianística, de uma obra-prima da literatura do Settecento italiano.
A Literatura é uma Geografia?
Authors: Alves Ida 
Published: September 2020

Desenvolve-se reflexão sobre a relação literatura e paisagem, a partir de fundamentação teórico-crítica que aborda a paisagem como construção cultural capaz de expressar de maneira questionadora a relação entre sujeito, mundo e palavra. A presença da paisagem em alguma produção poética de língua portuguesa pós-70 do século XX e a configuração de uma geografia lírica urbana produzida por subjetividades em tensão.
Geografia, Ciência... Arte. Novos olhares...
Authors: Silva Maria Auxiliadora da 
Published: September 2020

A experiência da Disciplina O Espaço Geográfico na Literatura, do programa de Mestrado em Geografia, da Universidade Federal da Bahia, no instigante e prazeroso diálogo entre a Geografia e a Arte, será abordada nas obras Visões Imaginárias da Cidade da Bahia. Um Diálogo entre a Geografia e a Literatura (2004) e Imagens da Cidade da Bahia. Um Diálogo entre a Geografia e a Arte (2007), na visão daqueles estudantes e pesquisadores que retrataram e recontaram a Cidade do Salvador em suas múltiplas representações, por meio da relação e do elo entre a arte e o espaço geográfico.