bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Diagnostic Proteins by 2D Electrophoresis in Major Depression Model Induced by Forced Swim Test in Rats
Authors: Duman Tuğçe , Akyüz Enes , Bulut Huri , Koçyiğit Abdurrahim , Tülek Ahmet , Karataş Ersin , Kırpınar İsmet 
Published: July 2020

Background:Aside from its pervasiveness, whereby it affects as much as 20% of the world's population, depression continues to be one of the most crucial psychiatric problems due to the loss of power it causes by disrupting daily life functioning, containing economic consequences, and having a high suicidal tendency. Major depression (MD) is a systemic and multifactorial disorder involving complex interactions between genetic predisposition and disturbances of various molecular pathways.Objectives:In our current study, we aimed to identify the proteins obtained from serum samples that change during depression with the MD model.Methods:The MD model was applied through the forced swim test in rats. 14 Winstar Albino male rats were divided into two equal groups as follows: depression and control groups. Serum samples were separated by chromatographic methods and then compared with two-dimensional (2D) electrophoresis.Results:A total of 9 potential diagnostic protein sequences were identified, which were distinguished with computer software. During the last phase of the study, the Matrix-Assisted Laser Desorption/ Ionization – Time of Flight (MALDI-TOF) analysis, the previous expression sequences identified among the groups were determined and classified. By comparing protein expressions, it was concluded that 9 different points could be used together as a potential biomarker.Conclusion:Results can help us identify a new diagnostic system that can be used to diagnose MD.
High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients
Authors: de  Queiroz Natércia Neves  Marques , de  Melo Franciane Trindade  Cunha , de Souza Resende Fabrício , Janaú Luísa Corrêa , de  Souza  Neto Norberto Jorge  Kzan , de Lemos Manuela Nascimento , de Oliveira Maria Clara Neres Iunes , de Alcântara Angélica Leite , de Moraes Lorena Vilhena , da Mota Queiroz Apolone , de Souza Ícaro José Araújo , Said Nivin Mazen , dos  Santos Márcia Costa , de Souza D’Albuquerque Silva Lilian , Motta Ana Regina Bastos , de Sá Oliveira dos Reis Melissa , Lobato Isabel Jane Campos , de Figueiredo Priscila Boaventura Barbosa , de  Souza Ana  Carolina Contente  Braga , Freire  Piani Pedro Paulo , Felício Karem Miléo , Abrahão Neto João Felício , Felício João Soares 
Published: July 2020

Background:
Vitamin D (VD) deficiency has been related to several endocrine metabolic
and cardiovascular diseases. The effect of VD supplementation on blood pressure (BP) in patients with
diabetes is controversial.

Objective:
The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood
pressure of normotensive patients with diabetes mellitus 1 (DM1) patients by 24-hour ambulatory blood
pressure monitoring (ABPM).

Methods:
We performed a clinical trial including 35 DM1 normotensive patients, who received doses of
4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent
24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before
and after VD supplementation.

Results:
We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs
112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers.
Besides, we noticed a relationship between levels of VD after supplementation and diastolic morning
blood pressure (r= -0,4; p<0.05).

Conclusion:
Our study suggests an association between supplementation of high doses of vitamin D
and the reduction of morning blood pressure in normotensive DM1 patients.
Wastewater Treatment and Biomedical Applications of Montmorillonite
Based Nanocomposites: A Review
Authors: Bhat Aabid Hussain , Rangreez Tauseef Ahmad , Inamuddin  , Chisti Hamida-Tun-Nisa 
Published: July 2020

Background::
Rapid industrialisation, population growth and technological race worldwide have brought adverse
consequences on water resources and as a result affect human health. Toxic metal ions, non-biodegradable dyes, organic
pollutants, pesticides, pharmaceuticals are among the chief hazardous materials released into the water bodies from various
sources. These hazardous contaminants drastically affect the flora and fauna globally leading to health deterioration there
by giving rise to new biomedical challenges.

Hypothesis::
Montmorillonite based nanocomposites (MMTCs) have drawn an attention of the researchers to design
environmental friendly, advanced and hygienic nanocomposites for wastewater treatment and biomedical purposes.
Montmorillonite clay possesses peculiar physical and chemical properties that include enhanced surface reactivity, improved
rheological performance, exorbitant miscibility in water due to which it shows highly favourable interactions with polymers,
drugs, metals, mixed metals and metal oxides leading to the fabrication of different types of advanced montmorillonite
based nanocomposites that have remarkable applications

Methodology::
Here we review the structural characteristics of montmorillonite clay, advances in the synthetic techniques
involved in the fabrication of montmorillonite nanocomposites, their applications in waste water treatment and in bio
medical field. The recently developed montmorillonite nanocomposites for (1) waste water treatment as nano-adsorbents
for the elimination of toxic inorganic species such as metal ions and heterogeneous photo-catalysts for photo degradation
of dyes, pesticides and pharmaceuticals (2) biomedical utilization viz drug delivery, wound amelioration, bone cement,
tissue engineering etc. are presented

Conclusion::
The review exclusively focuses on recent research on montmorillonite based nanocomposites and their
application in wastewater treatment and in biomedical field
Eco-friendly Spectrophotometric Methods for Assessment of Alfuzosin and Solifenacin in their new Pharmaceutical Formulation; Green Profile Evaluation via Eco-scale and GAPI Tools
Authors: Tantawy Mahmoud A. , Weshahy Soheir A. , Wadie Mina , Rezk Mamdouh R. 
Published: July 2020

Background::Alfuzosin is recently co-formulated with solifenacin for relieving two coincident urological diseases, namely; benign prostate hyperplasia and overactive bladder.Objective::Herein, green, simple and rapid spectrophotometric methods were firstly developed for simultaneous determination of the two cited drugs in their co-formulated pharmaceutical capsuleMethods::Alfuzosin, which is the major component in the dosage form, was directly assayed at its extended wavelength at 330.0 nm. The challenging spectrum of the minor component, solifenacin, was resolved by five spectrophotometric methods, namely; Dual Wavelength (DW) at 210.0 & 230.0 nm, first derivative (1D) at 222.0 nm, Ratio Difference (RD) at 217.0 - 271.0 nm , derivative ratio (1DD) at 223.0 and mean centering of ratio spectra (MC) at 217.0 nm.Results::The proposed methods were successfully validated as per ICH guidelines. Alfuzosin showed linearity over the range of 4.0 - 70.0 μg/mL, while that of solifenacin were 4.0 - 50.0 μg/mL for DW, 2.0 - 70.0 μg/mL for1D and RD methods, 1.0 - 70.0 μg/mL for1DD and 4.0 - 70.0 μg/mL for MC method. Statistical comparison with their official ones showed no noticeable differences. The methods showed good applicability for assaying drugs in their newly combination. Besides the eco-scale, the greenness profile of the methods was assessed and compared with the reported spectrophotometric one via the newest metric tool; Green Analytical Procedure Index (GAPI).Conclusions::The proposed methods are superior in not only being smart, accurate, selective, robust and time-saving, but also in using distilled water as an eco-friendly and cheap solvent.
PTSD and Burnout are Related to Lifetime Mood Spectrum in Emergency Healthcare Operator
Authors: Carmassi Claudia , Bertelloni Carlo Antonio , Avella Maria Teresa , Cremone Ivan , Massimetti Enrico , Corsi Martina , Dell’Osso Liliana 
Published: July 2020

Background:PTSD and burnout are frequent conditions among emergency healthcare personnel because exposed to repeated traumatic working experiences. Increasing evidence suggests high comorbidity between PTSD and mood symptoms, particularly depression, although the real nature of this relationship still remains unclear. The purpose of this study was to investigate the relationship between PTSD, burnout and lifetime mood spectrum, assessed by a specific scale, among health-care professionals of a major University Hospital in Italy.Methods:N=110 Emergency Unit workers of the Azienda Ospedaliero-Universitaria Pisana (Pisa, Italy) were assessed by the TALS-SR, MOODS-SR lifetime version and the ProQOL R-IV.Results:Approximately 60% of participants met at least one PTSD symptom criterion (criterion B, 63.4%; criterion C, 40.2%; criterion D 29.3%; criterion E, 26.8%), according to DSM-5 diagnosis. Almost sixteen percent of the sample reported a full symptomatic DSM-5 PTSD (work-related) diagnosis, and these showed significantly higher scores in all MOODS-SR depressive domains, as well as in the rhythmicity domain, compared with workers without PTSD. Further, mood-depressive and cognition-depressive MOODS-SR domains resulted to be predictive for PTSD. Significant correlations emerged between either PTSD diagnosis and criteria or ProQOL subscales and all the MOOD-SR domains.Conclusion:A significant association emerged among PTSD, burnout and lifetime MOOD Spectrum, particularly the depressive component, in emergency health care operators, suggesting this population should be considered at-risk and undergo regular screenings for depression and PTSD.
Health Related Quality of Life in Patients with Onco-hematological Diseases
Authors: La Nasa Giorgio , Caocci Giovanni , Morelli Emanuela , Massa Elena , Farci Antonio , Deiana Laura , Pintus Elisa , Scartozzi Mario , Sancassiani Federica 
Published: July 2020

Background:
HRQoL is generally conceptualized as a broad multidimensional construct that refers to patients' perceptions of the impact of disease and its treatment on their physical, psychological, and social functioning and well-being. Little is known in patients with onco-hematological cancer in comparison with the general population and other chronic diseases.

Objective:
We assessed HRQoL in patients diagnosed with haematological cancers in comparison with the general population and other chronic diseases.

Methods:
The questionnaire Short Form (SF)-12 was administered to 62 patients with onco-hematological disease and results were compared with 702 controls (184 healthy people, 37 Major Depression, 201 Multiple Sclerosis; 23 Wilson disease; 46 Carotidal Atherosclerosis; 60 Celiac disease; 151 solid tumours).

Results:
HRQoL in patients diagnosed with a haematological cancer was significantly worse in comparison with the general population (F= 43.853, p <0.00001) but similar when compared with solid tumour and other chronic diseases such as Major Depression and Carotid Atherosclerosis. In addition, HRQoL in patients diagnosed with a haematological cancer was significantly higher than that due to Celiac disease (p <0.00001) and Wilson's disease (p= 0.02), and lower than that due to Multiple Sclerosis (p= 0.032).

Conclusion:
This study confirmed that haematological cancers negatively affects overall HRQoL. The results showed an impact of haematological cancers on HRQoL that is similar to what found in patients with solid tumors, Major Depression and Carotid Atherosclerosis. Current successful therapeutic strategy achieved in the treatment of haematological cancers not only positively impact on survival rate but also could improve the overall HRQoL.
Arabic Version of the Personality Inventory for the DSM-5 (PID-5) in a Community Sample of United Arab Emirates Nationals
Authors: Coelho Olga , Pires Rute , Ferreira Ana Sousa , Gonçalves Bruno , AlJassmi Maryam , Stocker Joana 
Published: July 2020

Background:
Section III of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes a model for conceptualizing personality disorders in which they are characterized by impairments in personality functioning and maladaptive personality traits. The Personality Inventory for DSM-5 (PID-5) is a self-report measure that assesses the presence and severity of these maladaptive personality traits.

Objective:
The current study examined the reliability and validity of the Arabic version of the Personality Inventory for DSM-5 (PID-5) to measure maladaptive personality traits in the Emirati population of the United Arab Emirates.

Methods:
The Arabic version of the PID-5 was administered to a community sample of 1,090 United Arab Emirates nationals (89.5% female and 10.5% male, mean age = 22.44 years old). The descriptive measures, internal consistency, test-retest reliability, convergent validity with NEO – Five Factor Inventory, as well as PID-5’s factor structure, were all addressed.

Results:
The PID-5facets and domains mean scores were higher in the Emirati sample compared to the original US sample. Internal consistency of the PID-5 scales was acceptable to high and test-retest coefficients ranged from 0.84 (facets) to 0.87 (domains). As expected, the five domains of the Arabic version of the PID-5 correlated significantly with all Five-Factor Model domains of personality. Additionally, the Arabic version of the PID-5 confirmed a five-factor structure that resembles the PID-5 domains.

Conclusion:
The findings of this study provided initial support for the use of the Arabic version of the PID-5 to assess maladaptive personality traits in the Emirati population of the United Arab Emirates.
Vitamin D as a Potential Therapeutic Option in Cancer Treatment: Is There a Role for Chemoprevention?
Authors: Bahrami Afsane , Sahebkar Amirhossein 
Published: July 2020

Background:
Vitamin D (Vit D) serves as a precursor to the potent steroid hormone calcitriol, which
regulates numerous genes that control homeostasis, epithelial cell differentiation, proliferation, and apoptosis.
Low level of Vit D is implicated in the development and progression of several diseases including bone fractures,
cardiovascular disease, diabetes mellitus, and cancers. The present review highlights the role of vitamin D
in cancer with a particular emphasis on genetic variants related to Vit D metabolism as well as clinical trials of
Vit D supplementation as a potential therapeutic option in the treatment of cancer patients.

Methods:
Data were collected following an electronic search in the Web of Science, Medline, PubMed, and
Scopus databases by using some keywords such as “cancer”, “tumor”, “malignancy”, “vitamin D”, “cholecalciferol”
and “calcitriol”.

Results:
The collected evidence from the studies revealed a consistent and strong association between Vit D
status and cancer risk and survival. The associations between Vit D-related genetic variants and cancer survival
support the hypothesis that Vit D may affect cancer outcomes. The mechanisms whereby Vit D reduces cancer
risk and increases survival are regulation of cellular differentiation, proliferation and apoptosis as well as decreased
angiogenesis in tumor microenvironment and inhibition of metastasis.

Conclusion:
There is a paucity of evidence-based recommendations for the optimal 25(OH)D levels in patients
with cancer and the role of Vit D supplementation for primary or secondary prevention of cancer. Well-designed
and sufficiently powered randomized clinical trials are necessary to assess the clinical application of Vit D in
enhancing the clinical efficacy of standard and adjuvant chemotherapy regimens.
Biological Evaluation of Synthesized Naringenin Derivatives as Antimicrobial Agents
Authors: Murti Yogesh 
Published: July 2020

Background:
Flavonoids are among the most abundant plant secondary metabolites and
have been shown to have natural abilities as microbial deterrents and anti-infection agents in
plants. Naringenin as one of the flavonoids and its derivatives have been reported to exhibit antimicrobial
activity.

Aims:
The aim of the study was to evaluate synthesized novel naringenin derivatives (ND-1 to ND-
12) substituted at 3-position with bulky substituent by using the grinding technique (Claisen-
Schmidt reaction) as antimicrobial agents.

Methods:
Synthesized naringenin derivatives were evaluated for in-vitro antimicrobial activity by
“Agar disc diffusion method”.

Results:
Novel naringenin derivatives showed mild to moderate antimicrobial activity with respect
to standard drugs against two gram-positive, two gram-negative bacteria and two fungal strains.
The substitution of naringenin derivatives at position 3 with substituted phenyl rings showed variation
in activity as chloro, nitro and hydroxyl-substituted phenyl ring showed potent activity while
methoxy substituted phenyl ring impede the activity.

Conclusion:
In conclusion, on the basis of the above findings, the substituted naringenin scaffolds
may be selected as a skeleton for the development of flavonoid structurally-related compounds
having antimicrobial activity.
Evaluation of Korean-Language COVID-19–Related Medical Information on YouTube: Cross-Sectional Infodemiology Study
Authors: Moon Hana , Lee Geon Ho 
Published: July 2020

Background
In South Korea, the number of coronavirus disease (COVID-19) cases has declined rapidly and much sooner than in other countries. South Korea is one of the most digitalized countries in the world, and YouTube may have served as a rapid delivery mechanism for increasing public awareness of COVID-19. Thus, the platform may have helped the South Korean public fight the spread of the disease.

Objective
The aim of this study is to compare the reliability, overall quality, title–content consistency, and content coverage of Korean-language YouTube videos on COVID-19, which have been uploaded by different sources.

Methods
A total of 200 of the most viewed YouTube videos from January 1, 2020, to April 30, 2020, were screened, searching in Korean for the terms “Coronavirus,” “COVID,” “Corona,” “Wuhan virus,” and “Wuhan pneumonia.” Non-Korean videos and videos that were duplicated, irrelevant, or livestreamed were excluded. Source and video metrics were collected. The videos were scored based on the following criteria: modified DISCERN index, Journal of the American Medical Association Score (JAMAS) benchmark criteria, global quality score (GQS), title–content consistency index (TCCI), and medical information and content index (MICI).

Results
Of the 105 total videos, 37.14% (39/105) contained misleading information; independent user–generated videos showed the highest proportion of misleading information at 68.09% (32/47), while all of the government-generated videos were useful. Government agency–generated videos achieved the highest median score of DISCERN (5.0, IQR 5.0-5.0), JAMAS (4.0, IQR 4.0-4.0), GQS (4.0, IQR 3.0-4.5), and TCCI (5.0, IQR 5.0-5.0), while independent user–generated videos achieved the lowest median score of DISCERN (2.0, IQR 1.0-3.0), JAMAS (2.0, IQR 1.5-2.0), GQS (2.0, IQR 1.5-2.0), and TCCI (3.0, IQR 3.0-4.0). However, the total MICI was not significantly different among sources. “Transmission and precautionary measures” were the most commonly covered content by government agencies, news agencies, and independent users. In contrast, the most mentioned content by news agencies was “prevalence,” followed by “transmission and precautionary measures.”

Conclusions
Misleading videos had more likes, fewer comments, and longer running times than useful videos. Korean-language YouTube videos on COVID-19 uploaded by different sources varied significantly in terms of reliability, overall quality, and title–content consistency, but the content coverage was not significantly different. Government-generated videos had higher reliability, overall quality, and title–content consistency than independent user–generated videos.
Esfinge ou Caleidoscópio? O desafio da pesquisa em livros didáticos de História
Authors: Rocha Helenice Aparecida Bastos 
Published: July 2020

Situamos o problema da pesquisa do livro didático no Brasil, a partir do desafio colocado a sua análise em diversas partes do mundo. Tomamos o livro didático como repositório material de discursos didatizados sobre conhecimentos relativos a um campo específico de saber, com leitura mediada ou não, destinado ao público escolar. Na primeira parte, nos interessa “re”apresentar advertências trazidas a público por Alain Choppin, ao classificar os tipos de pesquisas sobre tais livros. Na segunda apresentaremos algumas alternativas teórico-metodológicas no escopo de uma parte dessas pesquisas e, entre elas, o percurso do projeto “Narrativa Histórica nos livros didáticos: tradição e rupturas.”
STUDI DESKRIPTIF KEBIJAKAN REDAKSIONAL HARIAN UMUM RADAR SULTENG DALAM PEMBERITAAN PERISTIWA BENCANA 28 SEPTEMBER
Authors: Antasari Citra 
Published: July 2020

Kebijakan redaksional adalah bagian yang tidak dapat dipisahkan dari ruang pemberitaan. Redaksi adalah garis start bagi para awak media dalam memulai tugas dan perannya dalam melakukan kerja-kerja jurnalistik, dan kebijakan menjadi acuan dasarnya. Kebijakan redaksiona berfungsi mengendalikan bagaimana sebuah surat kabar akan tampak di hadapan pembaca esok harinya. Dalam berbagai situasi, kebijakan redaksional diharapkan tetap memegang kendali, termasuk dalam situasi pasca bencana. Harian Umum Radar Sulteng merupakan salah satu surat kabar lokal di Sulawesi Tengah yang telah berdiri hampir dua dekade, yang ikut menjadi saksi dari bagaimana bencana gempa tsunami dan liquifaksi melanda Kota Palu September 2018 silam. Sejumlah kebijakan redaksional baru dikeluarkan dengan mempertimbangkan kondisi yang ada saat itu. Penelitian ini mencoba mengetahui bagaimana kebijakan redaksional Harian Umum Radar Sulteng diambil pasca bencana berlangsung, dan seperti apa pertimbangan yang menyertainya. Penelitian ini menggunakan penelitian deskriptif kualitatif dengan menggunakan metode wawancara sebagai teknik pengumpulan datanya. Diperoleh bahwa keseluruhan kebijakan yang diambil pasca bencana sehubungan dengan pemberitaan dilandaskan atas asas kemanusiaan dan sebagai bentuk tanggung jawab sosial media sebagai ideologi yang diyakini dalam kondisi tersebut.
A Review on Design and optimization of shell and tube heat exchanger by varying parameters
Authors: Kumar Shiv , Singh Dharamveer 
Published: July 2020

In recent years, thermal control systems performance has improved in numerous ways due to developments in control theory and information technology. Efforts have been made to produce more efficient heat exchangers by employing various methods of heat transfer enhancement. An increase in heat exchanger performance can lead to a more economical design of heat exchanger which can help to make energy, material & cost savings related to a heat exchange process. Compact heat exchangers (CHEs) technologies are expected to be one of the solutions for the new generation heat exchanger. In this paper are presented of the compact heat exchanger, Plate-fin heat exchanger, and Printed Circuit Heat Exchanger. And computation fluid dynamic is used which offers an alternative to the quick and inexpensive solution for the design and optimization of compact heat exchangers.