bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Efficient QoS-aware Services Selection in IoT using A Reputation Improved- Social Spider Optimization Algorithm
Authors: Abosaif Aghabi Nabil , Elrofai Salah Elfaki 
Published: September 2020

Abstract
Internet of Things (IoT) has been grown rapidly over the last years to connect a considerable number of spatially distributed objects or actuators. The connected objects create new functionality and provide various services to enhance and satisfy End-users daily lives. The issue is to provide the End-users with optimal services based on their requirements. The critical challenge is to select the optimal service from similar services functionally and various services non-functionality requirements (Quality of services). To achieve this challenge, this paper proposed a services selection model under QoS constraints in the IoT environment. The introduced model implements a meta-heuristic optimization algorithm with a friendly Likert scale measurement method. It aims to improve the performance of bio-inspired optimizing algorithms, called a Social Spider Optimization (SSO) Algorithm, by adding a reputation value to member's weight. The proposed model used a Likert scale measurement to evaluate the reputation of the services from the End-users. In the experiments, a comparative study was done between an original SSO and the proposed RI-SSO model. The results show the efficiency of the proposed RI-SSO model against the original SSO, in both maximization and minimization problems. It obtains a better outperform in terms of fitness values. ​​
Effectiveness of Oral Health Promotion Program for Persons with Severe Mental Illness: A Cluster Randomized Controlled Study
Authors: Kuo Mei-Wen , Yeh Shu-Hui , Chang Heng-Ming , Teng Po-Ren 
Published: September 2020

Abstract
Objective: To evaluate the effectiveness of a composite oral health promotion program designed to reduce dental plaque among persons with severe mental illness in a psychiatric institution. Methods: A cluster randomized controlled study was carried out in chronic psychiatric wards of a general hospital in central Taiwan. Sixty-eight eligible male individuals admitted to 2 wards were randomly assigned to an experimental and a control group. Participants in the experimental group underwent an oral health promotion program that consisted of biweekly group education sessions, and a 12-week individual behavioral modification for oral hygiene course. The participants in the control group received usual care only. Dental plaque (measured by the Plaque Control Index) was examined by a single dentist before and after the experiment. Each participant responded to a questionnaire regarding oral health knowledge, attitude and behavior before and after the experiment. Results: Fifty-eight individuals completed the study. Before the experiment, the plaque index was similar between the intervention group (68.9; N=27) and the control group (69.8; N=31). After the experiment, the plaque index was significantly better in the intervention group than in the control group (42.6 vs. 61.8; P<0.001). Participants in the intervention group also demonstrated better oral health knowledge, attitude and behavior than those in the control group after the experiment. Conclusions: A composite oral health promotion program using both group education and individual behavioral methods over a 12-week period was effective in both reducing dental plaque and improving the oral health knowledge of persons with severe mental illness in the institution.
Directional divergence of Ep300 duplicates in teleosts and its implications
Authors: Wang Xianzong , Yan Junli 
Published: September 2020

Abstract
Background: EP300 is a conserved protein in vertebrates, which serves as a key mediator of cellular homeostasis. Mutations and dysregulation of EP300 give rise to severe human developmental disorders and malignancy. Danio rerio is a promising model organism to study EP300 related diseases and drugs; however, the effect of EP300 duplicates derived from teleost-specific whole genome duplication should not just be neglected. Results: In this study, we obtained EP300 protein sequences of representative teleosts, mammals and sauropsids, with which we inferred a highly supported maximum likelihood tree. We observed that Ep300 duplicates ( Ep300a and Ep300b) were widely retained in teleosts and universally expressed in a variety of tissues. Consensus sequences of Ep300a and Ep300b had exactly the same distribution of conserved domains, suggesting that their functions should be still largely overlapped. We analyzed molecular evolution of Ep300 duplicates in teleosts, using branch-site models, clade models and site models. The results showed that both duplicates were subject to strong positive selection; however, for an extant species, generally at most one copy was under positive selection. At clade level, there was evident positive correlation between evolutionary rates, number of positively selected sites and gene expression levels. In Ostariophysi, Ep300a were under stronger positive selection than Ep300b; in Neoteleostei, another species-rich teleost clade, the contrary was the case. We also modeled 3D structures of zf-TAZ domain and its flanking regions of Ep300a and Ep300b of D. rerio and Oryzias latipes and found that in either species the faster evolving copy had more short helixes. Conclusions: Collectively, the two copies of Ep300 have undoubtedly experienced directional divergence in main teleost clades. The divergence of EP300 between teleosts and mammals should be greater than the divergence between different teleost clades. Further studies are needed to clarify to what extent the EP300 involved regulatory network has diverged between teleosts and mammals, which would also be helpful to explain the huge success of teleosts.
The Prognostic Value of Modified Glasgow Prognostic Score in Pancreatic Cancer: A Meta-analysis
Authors: Zhang Huan , Ren Dianyun , Jin Xin , Wu Heshui 
Published: September 2020

Abstract
Background: Several studies were conducted to explore the prognostic value of modified Glasgow Prognostic Score (mGPS) in pancreatic cancer, which reported contradictory results. The purpose of this meta-analysis was to summarize and further investigate the correlation between mGPS and overall survival (OS) in pancreatic cancer.Methods: A systematic literature search was performed in PubMed, EMBASE, ISI Web of Science, Cochrane library databases and OVID to identify eligible studies published from Jan 1, 2011 to June 20, 2020. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were used to detect the prognostic significance of mGPS in patients with pancreatic cancer.Results: A total of 222 non-repetitive studies were identified, and 20 related studies that explored the association between survival outcomes and mGPS in pancreatic cancer patients were finally enrolled in this meta-analysis. The results showed a significant correlation between high level of mGPS and poor OS (HR=1.50, 95% CI=1.20-1.89, P<0.0001). Similar results were observed in the subgroup analyses based on the treatment regimen and research region.Conclusions: Our study suggested the close association between poor prognosis and high level of mGPS, which will be helpful for future clinical applications in patients with pancreatic cancer.
A Rare Cause of Left Atrium Compression: Esophageal Achalasia
Authors: Chen Sih-Yao , Toh Han Siong , Chang Wei-Ting , Liao Chia-Te 
Published: September 2020

Abstract
Background Extrinsic compression of left atrium (LA) due to esophageal achalasia is uncommon. Patients might present with dysphagia, dyspnea, and even hemodynamic compromise. Prompt detection with thorough differential diagnosis is crucial for subsequent management. We presented a case with LA compression by esophageal achalasia, and literature review regarding the clinical manifestation, diagnosis, and treatment strategy was performed to provide an updating knowledge of the disease.Case presentation A 59-year-old relatively healthy man presented with dysphagia accompanied by chest tightness and breathlessness after a large meal. His chest X-ray film disclosed a widened mediastinum. The barium swallow esophagogram revealed contrast pooling at the esophagogastric junction with a bird beak shape. Meanwhile, the transthoracic echocardiogram showed a round-shaped, well bordered, hyperechogenic, and heterogeneous mass (5.1 cm x 3.8 cm in size) compressing the LA irrespective of the systolic or diastolic phase. A chest contrast-enhanced computed tomography scan showed diffuse esophageal dilatation with a smoothly thickening wall aligned compressing the LA. Due to the abovementioned image findings, extrinsic compression of LA by esophageal achalasia was diagnosed.ConclusionLA compression due to esophageal achalasia is not common. Remarkably, given a patient presenting dysphagia and concurrent dyspnea after meals, the clinicians should keep this differential diagnosis in mind. Echocardiography and esophagography are useful to ensure the diagnosis promptly.
Cytotoxic CD8+ T Cells Promote Granzyme B-Dependent Adverse Post-Ischemic Cardiac Remodeling
Authors: Zas Icia Santos , Lemarie Jeremie , Zlatanova Ivana , Cachanado Marine , Seghezzi Jean-Christophe , Benamer Hakim , Goube Pascal , Vandestienne Marie , Cohen Raphael , Ezzo Maya , Duval Vincent , Zhang Yujiao , Su Gin-Bo , Bizé Alain , Sambin Lucien , Bonnin Philippe , Branchereau Maxime , Heymes Christophe , Tanchot Corinne , Vilar Jose , Delacroix Clement , Hulot Jean-Sebastien , Cochain Clement , bruneval patrick , Danchin Nicolas , Tedgui Alain , Mallat Ziad , Simon Tabassome , Ghaleh Bijan , Silvestre Jean-sébastien , Ait-Oufella Hafid 
Published: September 2020

Abstract
Acute myocardial infarction (MI) is a common condition responsible for heart failure and sudden death. Here, we show that following acute MI in mice, CD8+ T lymphocytes are recruited and activated in the ischemic heart tissue, and release Granzyme B leading to cardiomyocyte apoptosis, adverse ventricular remodeling and deterioration of myocardial function. Depletion of CD8+ T lymphocytes decreases apoptosis within the ischemic myocardium, hampers inflammatory response, limits myocardial injury and improves heart function. These effects are recapitulated in mice with Granzyme B-deficient CD8+ T cells. The protective effect of CD8 depletion on heart function was confirmed by using a model of ischemia/reperfusion in pigs. Finally, we reveal that elevated circulating levels of Granzyme B in patients with acute MI predict increased risk of death at 1-year follow-up. Our work unravels an unsuspected deleterious role of CD8+ T lymphocytes following acute ischemia, and identifies novel therapeutic strategy targeting pathogenic CD8+ T lymphocytes in the setting of acute MI.
Detection of emetic toxin (ces) gene and antimicrobial susceptibility of Bacillus cereus isolates from Iranian traditional dairy products
Authors: Heydarzadeh Mahdieh , Javadi Afshin , Rad Mehdi Ghiami 
Published: September 2020

Abstract
Background

Bacillus cereus is known as one of the major foodborne pathogens that often associated with the contamination of raw milk and dairy products. The aim of this study was to isolate the emetic toxin-producing Bacillus cereus (B. cereus) in unpasteurized traditional dairy products. Also, the antimicrobial resistance pattern was investigated in the isolates.
Methods

For this purpose, 150 samples of unpasteurized ice cream, cheese, doogh, curd and butter (prepared by traditional method) were randomly selected from the market from March 2019 to July 2020. Samples were evaluated for the presence of emetic toxin-producing B. cereus using culture and PCR method.
Results

Sixteen of 150 (10.66%) samples were contaminated with B. cereus. This pathogen was isolated from one (3.33%) sample of ice cream, 9 (30%) of doogh, 6 (20%) of curd in the mean contamination levels of 2.0 ± 0.0 and 4.4 ± 0.6, respectively. B. cereus was not isolated from cheese and butter samples. The contamination level of curd to this bacterium was significantly higher than other products (p < 0.05). PCR results showed that 14 (78.5%) of 16 isolates contained the ces gene. The results of the antibiogram test showed that B. cereus isolates were resistant to penicillin, cefazolin and co-trimoxazole (trimethoprim-sulfamethoxazole), semi-sensitive to vancomycin and erythromycin, and sensitive to gentamicin, ciprofloxacin and clindamycin. Also, 31.25% of isolates were resistant to six antibiotics simultaneously.
Conclusion

The findings of present study showed that traditional unpasteurized dairy products could provide a great potential for intoxication by antimicrobial-resistance and emetic toxin-producing strains of B. cereus.
Prevalence and Spectrum of Complex Congenital Heart Disease in the Neonatal Intensive Care Unit at high Altitude in China
Authors: Li Jing-Jing , Wang Xiao-Rong , Liu Yuan , Zhao Guo-Dong , Dai Ting , Chen Hong , Liao Hai-Yan , Qi Hai-Ying , Li Jia 
Published: September 2020

Abstract
Background: Previous studies from high altitudes have reported significantly higher prevalence of congenital heart disease (CHD), consisting almost solely of simple CHD. Little is known about the occurrence of complex CHD. Neonates with complex CHD are likely admitted to NICU. We examined the prevalence and spectrum of complex CHD in NICU in order to depict a truer picture of CHD at high altitude.Methods: We reviewed charts of 4,214 neonates admitted to NICU in Qinghai province (average altitude 3,000m). Echocardiography was performed in 1,943 babies when CHD was suspected based on clinical examinations.Results: CHD was diagnosed in 1,093(56.3% of echoed babies). Mild CHD in 96.8%(1058 babies). Moderate CHD in 0.8%(9) included 1(0.1%) large secundum atrial septal defect, 3(0.3%) moderate pulmonary stenosis, 2(0.2%) aortic stenosis and 3(0.3%) partial anomalous pulmonary venous connection. Severe CHD in 2.4%(26) included 6(0.5%) complete atrioventricular septal defect, 5(0.5%) complete transposition of the great arteries, 5(0.5%) hypoplastic right heart, 3(0.3%) hypoplastic left heart, 3(0.3%) double outlet right ventricle, 3(0.3%) tetralogy of Fallot, 2(0.2%) truncus arteriosus, 2(0.2%) total anomalous pulmonary venous connection, 2(0.2%) severe aortic stenosis, 2(0.2%) Interrupted aortic arch and 2(0.2%) severe pulmonary stenosis and 1(0.1%) single-ventricle abnormality. At two-years follow-up in 737(67.4%) patients, 18(90%) with severe CHD and 38(5.3%) with mild and moderate CHD died, and 15 underwent cardiac surgery with 1 early death.Conclusions: At high altitude, a wide spectrum of CHD exists, with many heretofore unreported complex CHD. There is urgent need for routine echocardiography and early interventions in newborns particularly in NICU.
Improved Comprehensive Evaluation of Crohn's Disease Activity by Intestinal Computed Tomography Enterography Combined with Endoscopy and Biochemical Indicators
Authors: Liu yajun , tian feiyan , yi jun , gong lingqi , chen lulu , chen shuijiao , liu xiaowei 
Published: September 2020

Abstract
Background: The treatment goal for Crohn’s disease (CD) has turned towards mucosal healing and resolution of the transmural inflammation. The purpose of this study was to evaluate how well computed tomography enterography (CTE) correlated with other treatments, in particular, endoscopy and biochemical indicators, in newly diagnosed patients with CD.Methods: 123 patients with CD who received CTE in the Xiangya Hospital of Central South University, China, from April 2017 to April 2019 were included. Clinical case data and imaging results were retrospectively reviewed. The clinical activity of CD was determined by the Crohn’s disease activity index (CDAI) score and biochemical indicators. The relationships between CTE and endoscopy, CDAI score, and inflammatory markers were evaluated.Results: The diagnostic rate of CTE in the 123 CD patients was 68.3% (84/123). Logistic regression analysis showed that the specific CTE manifestations related to CD activity were intestinal wall stratification, comb sign, and abdominal abscesses (P < 0.05). Spearman’s rank correlation analysis showed that inflammatory markers correlated positively with different CTE imaging manifestations. The CTE findings were consistent with colonoscopy results in 136 intestinal segments (73.1%) in terms of lesion location but were not consistent in 50 intestinal segments (26.9%).Conclusion: intestinal CTE has a high degree of completion and is well tolerated, in contrast to endoscopy which is both invasive and unable to reflect the level of intestinal mucosal infiltration. In conclusion, intestinal CTE combined with endoscopy and biochemical indicators is both comprehensive and effective in evaluating the condition of CD patients.
Temporal Changes of Haematological and Radiological Findings of the COVID-19 Infection - A Review of Literature
Authors: Lim Albert Yick Hou , Leng Goh Jun , Mae Chua Chui Wei , Heng Bee Hoon , Abisheganaden John Arputhan , George Pradeep Paul 
Published: September 2020

Abstract
Background: COVID-19 is a systemic viral infection with many clinical manifestations especially affecting the hematopoietic system and haemostasis. Few studies have highlighted the prognostic value of blood findings such as lymphopenia, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, LDH, CRP, cardiac troponin, low-density lipoproteins and chest radiographic abnormality. A study of progressions of blood and radiological results may help to identify patients at high risk of severe outcomes. This systematic review aimed to assess the temporal progression of blood and radiology findings of patients with COVID-19. Methods: Comprehensive systematic literature search was conducted on Medline, Embase and Cochrane databases to identify articles published for peripheral blood investigation and radiological results of COVID-19 patients. Results: A total of 27 studies were included in this review. The common laboratory features reported include lymphopenia, elevated levels of C-reactive proteins and lactate dehydrogenase. For radiological signs, ground-glass opacifications, consolidations, and crazy paving patterns were frequently reported. There is a correlation between lymphocyte count, neutrophil count and biomarkers such as C-reactive proteins and lactate dehydrogenase; at a later phase of the disease (more than 7 days since onset of symptoms), lymphopenia worsens while neutrophil count, C-reactive protein levels and lactate dehydrogenase levels increase. Frequencies of ground-glass opacifications and ground-glass opacifications with consolidations decrease at a later phase of the disease while that of consolidation and crazy paving pattern rises as the disease progresses. More extensive lung involvement was also seen more frequently in the later phases. Conclusions: The correlation between temporal progression and the reported blood and radiological results may be helpful to monitor and evaluate disease progression and severity.
Innovative Trial Approaches in Immune-Mediated Inflammatory Diseases: Current Use and Future Potential
Authors: Grayling Michael J , Bigirumurame Theophile , Cherlin Svetlana , Ouma Luke , Zheng Haiyan , Wason James 
Published: September 2020

Abstract
Background: Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest form of evidence on the effectiveness of a potential new treatment regimen, but they are extremely expensive and time consuming to conduct. Consequently, much focus has been given in recent years to innovative design and analysis methods that could improve the efficiency of RCTs. In this article, we review the current use and future potential of these methods within the context of IMID trials.Methods: We provide a review of several innovative methods that would provide utility in IMID research. These include novel study designs (adaptive trials, Sequential Multi-Assignment Randomised Trials, basket, and umbrella trials) and data analysis methodologies (augmented analyses of composite responder endpoints, using high-dimensional biomarker information to stratify patients, and emulation of RCTs from routinely collected data). IMID trials are now well-placed to embrace innovative methods. For example, well-developed statistical frameworks for adaptive trial design are ready for implementation, whilst the growing availability of historical datasets makes the use of Bayesian methods particularly applicable.To assess whether and how these innovative methods have been used in practice, we conducted a review via PubMed of clinical trials pertaining to any of 51 IMIDs that were published between 2018-20 in five high impact factor clinical journals. Results: Amongst 97 articles included in the review, 19 (19.6%) used an innovative design method, but most of these were relatively straightforward examples of innovative approaches. Only two (2.1%) reported the use of evidence from routinely collected data, cohorts, or biobanks. Eight (9.2%) collected high-dimensional data. Conclusions: Application of innovative statistical methodology to IMID trials has the potential to greatly improve efficiency, to generalise and extrapolate trial results, and to further personalise treatment strategies. Currently, such methods are infrequently utilised in practice. New research is required to ensure that IMID trials can benefit from the most suitable methods.
The impact of climate change on the productivity of conservation agriculture
Authors: Su Yang , Gabrielle Benoît , Makowski David 
Published: September 2020

Abstract
Conservation agriculture (CA) is being promoted as a set of management practices that can sustain crop production while providing positive environmental externalities. However, its impact on crop productivity is still hotly debated, and how this productivity will be affected by climate change remains uncertain. Here we compared the productivity of CA vs. conventional tillage (CT) systems under current and future climate conditions using a probabilistic machine-learning approach at the global scale. We reveal large differences in the probability of yield gains with CA across crop types, climate zones, and geographical regions. We show that, for most crops, CA performed better in continental, arid and temperate regions than in tropical ones. Under future climate conditions, the relative productive performance of CA is expected to increase for maize in almost all cropping areas within the tropical band, thus improving the competitiveness of CA for this major crop.