bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report
Authors: Mitani Yosuke , Kanai Masashi , Kou Tadayuki , Kataoka Shigeki , Doi Keitaro , Matsubara Junichi , Ohashi Shinya , Matsumoto Shigemi , Muto Manabu 
Published: December 2020

Abstract
Background
Cancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis is generally poor, with a median survival of less than a year. Thus, clinicians eagerly await the development of more effective treatment strategies. In recent years, advances in next-generation sequencing (NGS) have made it possible to analyze comprehensively the genome of individual cancers. NGS has identified many genomic alterations, some of which are potential molecular targets of specific agents. We report a case of CUP that was successfully treated with targeted therapy directed by the genomic data obtained from an NGS-based multiplex assay.

Case presentation
A 52-year-old Asian woman with right hip joint pain underwent fluorodeoxyglucose-positron emission tomography/computed tomography, which showed multiple metastatic tumors in her right hip joint, thyroid gland, lung, and vertebrae. Brain magnetic resonance imaging showed multiple cerebral metastases. Additional tests, including pathology examination and conventional epidermal growth factor receptor (EGFR) gene mutation analysis (single-strand conformation polymorphism assay), could not identify the primary origin of the tumors, so the patient was diagnosed with CUP. After empirical chemotherapy for CUP, an NGS-based multiplex assay performed using a resected specimen of thyroid tumor detected the EGFR mutation c.2573 T > G p.Leu858Arg (L858R). Her treatment was changed to erlotinib, an EGFR tyrosine-kinase inhibiter, which dramatically shrank the tumors and decreased her serum carcinoembryonic antigen level. She achieved long-term disease control and survived for 2 years and 9 months from the first diagnosis.

Conclusion
This case might support the strategy that NGS-based multiplex assays could identify actionable molecular targets for individual patients with CUP.
“It brought hope and peace in my heart:” Caregivers perceptions on kangaroo mother care services in Malawi
Authors: Nyondo-Mipando Alinane Linda , Kinshella Mai-Lei Woo , Salimu Sangwani , Chiwaya Brandina , Chikoti Felix , Chirambo Lusungu , Mwaungulu Ephrida , Banda Mwai , Newberry Laura , Njirammadzi Jenala , Hiwa Tamanda , Vidler Marianne , Dube Queen , Molyneux Elizabeth , Mfutso-Bengo Joseph , Goldfarb David M. , Kawaza Kondwani 
Published: December 2020

Abstract
Background
Kangaroo mother care (KMC) is an effective intervention for preterm and low birth weight infants. Effective implementation of KMC relies on a multidisciplinary team centering on the newborn’s caregiver, who delivers care with support from health care workers. This study explored the experiences of caregivers on the implementation of KMC.

Methods
We conducted a descriptive qualitative study in the phenomenological tradition, an interpretative approach to describe the caregivers’ lived experience with KMC at four health facilities in Malawi from April and June 2019 through 10 non-participatory observations and 24 face-to-face interviews. We drew a purposive sample of 14 mothers, six fathers, three grandmothers, and one grandfather of infants receiving KMC in three secondary and one tertiary level hospitals. Data were analyzed following a thematic approach.

Results
Caregivers had limited information on KMC before admission with most of the information learned from peers rather than medical professionals. Stories of positive outcomes following KMC contributed to a shift in perceptions of premature babies and acceptability of KMC as an effective intervention. Unintended consequences resulting from admission due to KMC disrupts responsibilities around the home and disrupts economic activities. Gender division of roles exists with the implementation of KMC and a mother’s support networks are crucial.

Conclusion
Kangaroo mother care is feasible and acceptable among caregivers. KMC babies are described more positively with the potential to grow into strong and healthy children. KMC remains focused on the mother, which undervalues the important roles of her support network. A change in the nomenclature from kangaroo mother care to kangaroo care would include fathers and others delivering care.
Bronchoscopist's perception of the quality of the single-use bronchoscope (Ambu aScope4™) in selected bronchoscopies: a multicenter study in 21 Spanish pulmonology services
Authors: Flandes Javier , Giraldo-Cadavid Luis Fernando , Alfayate Javier , Fernández-Navamuel Iker , Agusti Carlos , Lucena Carmen M. , Rosell Antoni , Andreo Felipe , Centeno Carmen , Montero Carmen , Vidal Iria , García-Alfonso Lucía , Bango Antonio , Ariza Miguel , Gallego Rocío , Orta Marta , Bello Salvador , Mincholé Elisa , Torrego Alfons , Pajares Virginia , González Héctor , Wangüemert Aurelio Luis , Pérez-Izquierdo Julio , Disdier Carlos , de Vega Sanchez Blanca , Cordovilla Rosa , Cascón Juan , Cruz Antonio , García-López J. Javier , Puente Luis , Benedetti Paola , García-Gallo Cristina L. , Díaz Nuevo Gema , Aguado Silvia , Partida Concepción , Díaz-Agero Prudencio , Luque Crespo Estefanía , Pavón María , Páez Francisco , Cases Enrique , Martínez Raquel , Briones Andrés , Fernández Cleofe , Martín Serrano Concepción , Uribe-Hernández Ana Maria , Robles Jose 
Published: December 2020

Abstract
Background
The disposable bronchoscope is an excellent alternative to face the problem of SARS-CoV-2 and other cross infections, but the bronchoscopist's perception of its quality has not been evaluated.

Methods
To evaluate the quality of the Ambu-aScope4 disposable bronchoscope, we carried out a cross-sectional study in 21 Spanish pulmonology services. We use a standardized questionnaire completed by the bronchoscopists at the end of each bronchoscopy. The variables were described with absolute and relative frequencies, measures of central tendency and dispersion depending on their nature. The existence of learning curves was evaluated by CUSUM analysis.

Results
The most frequent indications in 300 included bronchoscopies was bronchial aspiration in 69.3% and the median duration of these was 9.1 min. The route of entry was nasal in 47.2% and oral in 34.1%. The average score for ease of use, image, and aspiration quality was 80/100. All the planned techniques were performed in 94.9% and the bronchoscopist was satisfied in 96.6% of the bronchoscopies. They highlighted the portability and immediacy of the aScope4TM to start the procedure in 99.3%, the possibility of taking and storing images in 99.3%. The CUSUM analysis showed average scores > 70/100 from the first procedure and from the 9th procedure more than 80% of the scores exceeded the 80/100 score.

Conclusions
The aScope4™ scored well for ease of use, imaging, and aspiration. We found a learning curve with excellent scores from the 9th procedure. Bronchoscopists highlighted its portability, immediacy of use and the possibility of taking and storing images.
Local and global analysis of a nonlinear duopoly game with heterogeneous firms
Authors: Askar Sameh 
Published: December 2020

AbstractIn this paper, we introduce a nonlinear duopoly game whose players are heterogeneous and their inverse demand functions are derived from a more general isoelastic demand. The game is modeled by a discrete time dynamic system whose Nash equilibrium point is unique. The conditions of local stability of Nash point are calculated. It becomes unstable via two types of bifurcations: flip and Neimark–Sacker. Some local and global numerical investigations are performed to show the dynamic behavior of game’s system. We show that the system is noninvertible and belongs to$Z_{2}-Z_{0}$Z2−Z0type. We also show some multistability aspects of the system including basins of attraction and regions known as lobes.
Risk management in the era of recovery and rights
Authors: Carroll Andrew , McSherry Bernadette 
Published: December 2020

SUMMARYClinical decision-making in psychiatry is affected by many factors, including how best to reduce risks of harm while promoting autonomy and personal recovery. This article proposes guidance for clinical decision-making that is consistent with civil liability law. It emphasises collaboration, clarification of the available information and communication of decisions as a basis for recovery-oriented risk management.
Sensory neuron cultures derived from adult db/db mice as a simplified model to study type-2 diabetes-associated axonal regeneration defects
Authors: De Gregorio Cristian , Ezquer Fernando 
Published: December 2020

ABSTRACT
Diabetic neuropathy (DN) is an early common complication of diabetes mellitus (DM), leading to chronic pain, sensory loss and muscle atrophy. Owing to its multifactorial etiology, neuron in vitro cultures have been proposed as simplified systems for DN studies. However, the most used models currently available do not recreate the chronic and systemic damage suffered by peripheral neurons of type-2 DM (T2DM) individuals. Here, we cultured neurons derived from dorsal root ganglia from 6-month-old diabetic db/db-mice, and evaluated their morphology by the Sholl method as an easy-to-analyze readout of neuronal function. We showed that neurons obtained from diabetic mice exhibited neuritic regeneration defects in basal culture conditions, compared to neurons from non-diabetic mice. Next, we evaluated the morphological response to common neuritogenic factors, including nerve growth factor NGF and Laminin-1 (also called Laminin-111). Neurons derived from diabetic mice exhibited reduced regenerative responses to these factors compared to neurons from non-diabetic mice. Finally, we analyzed the neuronal response to a putative DN therapy based on the secretome of mesenchymal stem cells (MSC). Neurons from diabetic mice treated with the MSC secretome displayed a significant improvement in neuritic regeneration, but still reduced when compared to neurons derived from non-diabetic mice. This in vitro model recapitulates many alterations observed in sensory neurons of T2DM individuals, suggesting the possibility of studying neuronal functions without the need of adding additional toxic factors to culture plates. This model may be useful for evaluating intrinsic neuronal responses in a cell-autonomous manner, and as a throughput screening for the pre-evaluation of new therapies for DN.
Mechanisms influencing and prediction of tool influence function spots during hemispherical sub-aperture tool polishing on fused silica
Authors: Suratwala T. , Menapace J. , Steele R. , Wong L. , Tham G. , Ray N. , Bauman B. , Gregory M. , Hordin T. 
Published: December 2020

Sub-aperture tool polishing of precision optics requires a detailed understanding of the local material removal [tool influence function (TIF)] at the contact spot between the workpiece and tool to achieve high removal determinism and hence precision of the optic relative to the desired/design surface figure. In this study, the mechanisms influencing and the quantitative prediction of the removal rate and shape of TIF spots during polishing of fused silica glass with cerium oxide slurry using a rotating hemispherical pad-foam tool for a wide variety of process conditions (including tool properties, kinematics, and applied displacements) are investigated. The TIF volumetric removal rate can be estimated utilizing the average relative velocity and contact area using a simple analytical model. In addition, stability of the volumetric removal rate for fixed process conditions is shown to be greatly dependent on the pad preparation and amount of tool use (affecting both pad topography and slurry buildup), whose general behavior shows an increase in removal rate followed by stabilization with polishing time. The determination of the TIF removal shape is more complex. An extended version of the Preston removal model is developed to explain a comprehensive set of measured TIF removal shapes to within

∼

22

%

. This model incorporates a number of phenomena impacting the TIF removal shape including: (a) temporal and spatial dependent relative velocity between the workpiece and tool; (b) an elastic mechanics based, as well as hydrodynamic, pressure distribution; (c) a spatially dependent friction coefficient possibly caused by both reduced slurry replenishment in low velocity regions and pad slurry islands (100 µm scale) and porosity (millimeter scale); and (d) a shear-based removal mechanism on the periphery of the contact spot.
Theatre and (Im)migration, edited by Yana Meerzon (2019)
Authors: Parry-Davies Ella 
Published: December 2020

Review of: Theatre and (Im)migration, edited by Yana Meerzon (2019)
Toronto: Playwrights Canada Press,
ISBN: 9 7803 6910 0016, 576 PP., A$69.97 (PBK)
Leverage dan Profitabilitas dalam Memprediksi Financial Distress Perusahaan Pertambangan Periode 2016-2018
Authors: Giovanni Axel , Utami Devi Wahyu , Yuzevin Thesya 
Published: December 2020

Financial distress merupakan suatu kondisi di mana sebuah perusahaan mengalami kesulitan keuangan. Adanya fenomena perusahaan yang ter-delisting dari Bursa Efek Indonesia menjadi dasar untuk mengkaji ulang model prediksi kesulitan keuangan yang tepat. Penelitian ini bertujuan untuk memberikan bukti secara empiris mengenai pengaruh leverage dan profitabilitas dalam memprediksi financial distress. Sampel penelitian diperoleh dengan menggunakan metode purposive sampling. Sampel penelitian yang memenuhi kriteria sebanyak 40 perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2018. Dalam penelitian ini, pengelompokkan perusahaan yang mengalami financial distress menggunakan model Altman Z-score. Pengujian hipotesis dalam penelitian ini menggunakan regresi logistik. Berdasarkan hasil analisis regresi logistik dengan tingkat signifikansi 5%, hasil penelitian ini menunjukkan bahwa leverage memiliki pengaruh negatif dan signifikan terhadap prediksi financial distress serta profitabilitas memiliki pengaruh positif dan signifikan terhadap prediksi financial distress. Penelitian selanjutnya diharapkan mempertimbangkan aspek makroekonomi dalam memprediksi kondisi financial distress perusahaan.
URBAN MOVEMENTS IN THE PROCESS OF THE LEGITIMATION OF LIBERAL DEMOCRACY: ANALYSIS OF THE ACTIVITIES OF ALTERNATIVE GROUPS AND CIVIL ORGANISATIONS AT A TIME OF EUROPEAN CRISIS
Authors: LEWENSTEIN BARBARA 
Published: December 2020

This paper constitutes an analysis of urban movements, marked in the research as alternative groups and civil organisations, in terms of the new politics characteristic of new social movements. In particular it indicates that these movements, ostensibly urban, actually express demands towards the broader social system, delegitimating it in a twofold manner. Firstly, the acceptance of certain general principles in democratic values and rules is coupled with criticism of how the system functions in practice and of the political elites in Poland, via protest, lobbying, and watchdog activities. A separate type of delegitimation embraces organisations among which we may list cooperatives and squats, as well as organisations managing concrete spaces and withdrawing from participation in public life, shutting themselves away within autonomous spaces and realising a different cultural and democratic model. In both of these groups we are thus dealing with a strongly accentuated anti-systemic and anti-capitalist attitude towards the political reality of the period of transformation in Poland. The research delivered confirmation of the overall research hypothesis adopted in the Lifewhat project, according to which in response to economic crisis civil society responds with the emergence of alternative forms of resilience, not only alleviating the consequences of the crisis but which also, as time passes and the scale of their activities increases, may give rise to a new quality – including in a political sense. The research constitutes a part of the international Lifewhat project. It was conducted on a sample of eighteen purposefully selected civil groups and organisations operating in large cities in Poland, using the method of in-depth interviews.
Development of Intelligent Smart Metering System through Remote Monitoring and Control under Robust Conditions
Authors: Priyadharshini S. G. , Subramani C. , Preetha Roselyn J. 
Published: December 2020

Abstract
This paper discusses the development of intelligent smart metering infrastructure for smart buildings based on information and communication technologies. The system collects electrical parameters, like real power, reactive power, voltage, current, power factor, and energy consumption, and physical parameters, such as temperature, humidity, and occupancy of the building. The electrical data are collected using Raspberry Pi 3B along with Smart Pi module. The physical parameters are collected by using a wide range of sensors communicating with the data acquisition module wirelessly by Wi-Fi technology. The monitoring platform is developed both in the customer end for the energy user and remote end for monitoring and control by the system operator. The developed system also has a parallel mode of communication based on LoRa technology, which will come into the picture if the primary mode of communication fails, ensuring there is always a continuous transfer of data under natural disaster situations. In addition, the system has an occupancy detection–based Internet of Things control module through which the system operator can remotely control selected appliances in the customer side based on the occupancy of the building as well as during disaster situations. The developed system also paves the way for secured smart buildings by continuous tracking of the building physical parameters, like temperature, humidity, and occupancy of the building during emergency situations like floods, earthquakes, and terrorist attacks, by which relief operations can be provided.
Three Steps Towards the Phenomenology of Literature with Arūnas Sverdiolas
Authors: Levina Jūratė 
Published: December 2020

The paper outlines the methodological orientation of Arūnas Sverdiolas’s scholarship and his school towards the praxis of the hermeneutic understanding of concrete cultural phenomena and takes this approach into the field of the phenomenology of literature. The attempt begins with a definition of the literary work in the hermeneutic framework of discourse, in which the work is considered to be an utterance that expresses an originary grasp of world phenomena. This capacity of the work to express is enabled by the operative mechanism of discourse, which binds, by the means of grammar and reference, the linguistic form of the work to the intentional structure of experience. To show this mechanism at work, the paper looks into Alfonsas Nyka-Niliūnas’s project of self-creation: Sverdiolas examines the poet’s diaries to reconstruct his effort of cultivating his poetic ego along the hermeneutic lines of the existential time, while Nyka-Niliūnas himself expresses this self-conception poetically as a more general phenomenon – the phenomenon of poetic self-consciousness as such – in the poem “Autobiography 1986”.
Problematic Issues of Information Security of Cyber-Physical Systems
Authors: Levshun Dmitry , Gaifulina Diana , Chechulin Andrey , Kotenko Igor 
Published: December 2020

This paper is an analysis and systematization of modern research in the field of cyber-physical system information security. The problematic issues of information security of such systems are considered: «what is being attacked?», «who is attacking?», «why is someone attacking?», «how is someone attacking?» and «how to protect the system?». As an answer to the first question, the paper proposes a definition and classification of cyber-physical systems according to such criteria as complexity, connectivity, criticality and social aspect. As an answer to the second and the third questions, the paper describes a classification of attacker according to such criteria as type of access, method of access, intentions, knowledge and resources. As an answer to the fourth question, the paper contains a classification of attack actions according to such criteria as subject and object, method of influence, prerequisites and consequences. As an answer to the fifth question, the paper proposes a classification of protection methods and security tools according to such criteria as principle of operation, object of protection and task to be solved. The scientific significance of the paper is systematization of a current state of the art in the subject area. The practical value of the paper is providing information about security issues that are specific to cyber-physical systems, which will allow one to develop, manage and use such systems in a more secure way.
Backprojection Imaging of the 2020 Mw 5.5 Magna, Utah, Earthquake Using a Local Dense Strong-Motion Network
Authors: Mesimeri Maria , Zhang Hao , Pankow Kristine L. 
Published: December 2020

Abstract
We present the application of a backprojection method for imaging the detailed rupture of the 2020 Mw 5.5 Magna, Utah, earthquake. This is the first time that this method is applied to an earthquake smaller than Mw 6 in a local scale using a dense strong-motion network. The 2020 Magna earthquake occurred in a very well instrumented area, the Salt Lake valley, with tens of strong-motion seismic stations. We use envelopes of high-frequency S waves recorded on the transverse component at 45 seismic stations that are located at distances up to 100 km from the epicenter. The nearest station is ∼4.5  km. Backprojection resolves the epicentral location of the mainshock with an absolute error of less than 1 km, whereas the depth resolution is within the centroid depth range of multiple moment tensor solutions. Spatial distribution of the imaged subevents shows an up-dip unilateral west-northwest–east-southeast rupture with a length of ∼10  km, consistent with the distribution of early aftershocks. The average rupture speed is between 2.9 and 3.2  km/s for the first 2 and 3 s, respectively. The shallow dip (∼35°) of the Wasatch fault at depth, which failed during the Magna earthquake, combined with the up-dip unilateral rupture, indicates that ground-motion scenarios for future larger earthquakes in the Salt Lake Valley should be re-evaluated. This study underlines the need for instrumenting metropolitan areas of high seismic risk and adopting backprojection techniques in the near-real-time network products immediately after a strong earthquake.
The cultural improvement theory and the social sciences’ intellectual crisis
Authors: Oyarzo Felipe 
Published: December 2020

The concept of culture continues to be studied from many different approaches and fields. This investigation focuses on answering the following two research questions: (1) Can cultures be improved? and (2) Should cultures be improved? Interviews were conducted with families, high school and college students and with professional adults. The cultural improvement theory is offered as a more objective method to analyse reality than the ideas suggested by the oppression theory. Most participants were not able to identify the importance of culture for a society or its possible connections to social well-being, economic development or the thinking processes of the brain. The interviews conducted with four families and the historical cases analysed in this project suggested that culture can be improved in order to facilitate social well-being and economic development.

Keywords: Culture, well-being, mentality, brain, oppression.