bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for a Nested Randomized Controlled Trial to Evaluate the Feasibility and Preliminary Efficacy of the Mindfulness Based Health Promotion Program on the Quality of Life of Older Adults Assisted in Primary Care—“The MBHP-Elderly Study”
Authors: Mapurunga Marcelo Vasconcelos , Andreoni Solange , de Oliveira Daniela Rodrigues , Sarubbi Vicente , Bonilha Ana Cláudia , D'Almeida Vania , Tomita Luciana , Ramos Luiz Roberto , Demarzo Marcelo 
Published: November 2020

Introduction: Population aging is a global phenomenon that has grown rapidly and progressively all over the world. Interventions that promote health must be studied and implemented to make the aging process be with quality of life. Depression and anxiety are the most common mental health conditions that compromise the quality of life on the elderly and it can cause damage to the autonomy and activities of daily life. Mindfulness training has been shown to improve psychological health and quality of life on adults. Studies involving Mindfulness-Based Interventions (MBIs) with older people are scarce in the literature, but they have been increasing in recent years showing promising results for healthy aging. This trial will investigate the feasibility and preliminary efficacy of an MBI on the quality of life of elderly assisted in the Primary Care.Materials and Methods: A cohort-nested randomized controlled trial with 3 assessment points (baseline, post-intervention and 1-year follow up) will be conducted to compare a MBI program (Mindfulness-Based Health Promotion) to a cognitive stimulation control-group in a Primary Care facility. One-hundred and two older adults will be recruited from a cohort of this facility and they will be randomized and allocated into an intervention group (N = 76) and the control group (N = 76). The primary outcome evaluated will be the improvement of quality of life assessed by the WHOQOL-BREF and WHOQOL-OLD. The secondary outcomes will be cognitive function, psychological health, sleep quality, self-compassion, and religiosity. Qualitative data will be assessed by focus group and the word free evocation technique. The feasibility of the program will also be evaluated by adherence and unwanted effects questionnaires.Discussion: This cohort-nested clinical trial will be the first mixed-methods study with 3 assessment points which will study the feasibility and preliminary efficacy of a mindfulness-based program for older people in Latin America population. If the findings of this study confirm the effectiveness of this program in this population it will be possible to consider it as intervention that might be implemented as public policy addressed to older people in healthcare systems.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03048708. Registered retrospectively on October 11th 2018.
Case Report: Recurrence of Positive SARS-CoV-2 Results in Patients Recovered From COVID-19
Authors: Zhang Ren-zi , Deng Wang , He Jing , Song Yu-yan , Qian Chun-fang , Yu Qian , Wang Dao-xin 
Published: November 2020

Background: Coronavirus disease 2019 (COVID-19) is spreading throughout the world. Limited data are available for recurrence of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in patients with long duration of COVID-19.Methods: We reported four cases recovered from COVID-19 with recurrence of positive SARS-CoV-2 results during the long-term follow-up.Results: The four patients recovered from COVID-19 showed recurrence of positive SARS-CoV-2 results for more than 120 days with no symptoms and normal chest CT scan.Conclusions: The dynamic surveillance of SARS-CoV-2 by nucleic acid detection and serological assays is important for asymptomatic patients who might be potentially infectious.
Motor Function Relating to the Accuracy of Self-Overestimation Error in Community-Dwelling Older Adults
Authors: Kawasaki Tsubasa , Tozawa Ryosuke 
Published: November 2020

Background: Older adults often overestimate their motor performance, which represents a serious safety hazard. The cause of this self-overestimation is to date, not yet fully established. Thus, the present study aimed to reveal the factors associated with self-overestimation by focusing on motor function.Methods: This study included 105 community-dwelling older adults [20 males, median (25, 75 percentile) age: 73.00 (69.50, 77.50)]. Participants were assessed for errors in their self-estimation using a two-step test. They estimated the two-step distance that could be reached with maximum effort. Thereafter, they performed the actual two-step action. Participants were comprehensively assessed for motor function by various tests (i.e., 10-meter Walking Test, Timed Up and Go Test, postural stability, and muscle strength). They were then divided into two groups (the self-underestimation or self-overestimation group) and their motor performances were compared. Multiple linear regression analysis was then utilized to investigate the relationship between self-estimation error and motor function.Results: Significant differences were found between the two groups regarding age, weight, actual two-step distance, and the time required for the Timed Up and Go Test and 10-meter Walking Test (p &lt; 0.05). The regression analysis showed that self-estimation error was significantly related to the result of the 10-meter Walking Test (beta = 0.24, p = 0.011).Conclusions: The self-overestimation of motor performance, which is likely to lead to several dangers (i.e., falling or obstacle collision), was related to walking ability. Consequently, the results showed that the 10-meter Walking Test would assist in detecting the self-overestimation of motor performance.
Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
Authors: Li Songtao , Qian Qianyu , Ying Na , Lai Jianfei , Feng Luyan , Zheng Sitong , Jiang Fusheng , Song Qing , Chai Hui , Dou Xiaobing 
Published: November 2020

Background: Salvianolic acid A (Sal A), a natural polyphenol compound extracted from Radix Salvia miltiorrhiza (known as Danshen in China), possesses a variety of potential pharmacological activities. The aim of this study is to determine mechanisms of hepatoprotective effects of Sal A against lipotoxicity both in cultured hepatocytes and in a mouse model of fatty liver disease.Methods: High-fat and high-carbohydrate diet (HFCD)-fed C57BL/6J mice were employed to establish hepatic lipotoxicity in a mouse model. Two doses of Sal A were administered every other day via intraperitoneal injection (20 and 40 mg/kg BW, respectively). After a 10-week intervention, liver injury was detected by immunohistochemical and biochemical analyses. For in vitro studies, we used HepG2, a human hepatoma cell line, and exposed them to palmitic acid to induce lipotoxicity. The protective effects of Sal A on palmitic acid-induced lipotoxicity were examined in Sal A-pretreated HepG2 cells.Results: Sal A treatments attenuated body weight gain, liver injury, and hepatic steatosis in mice exposed to HFCD. Sal A pretreatments ameliorated palmitic acid-induced cell death but did not reverse effects of HFCD- or palmitate-induced activations of JNK, ERK1/2, and PKA. Induction of p38 phosphorylation was significantly reversed by Sal A in HFCD-fed mice but not in palmitate-treated HepG2 cells. However, Sal A rescued hepatic AMP-activated protein kinase (AMPK) suppression and sirtuin 1 (SIRT1) downregulation by both HFCD feeding in mice and exposure to palmitate in HepG2 cells. Sal A dose-dependently up-regulated p-AMPK and SIRT1 protein levels. Importantly, siRNA silencing of either AMPK or SIRT1 gene expression abolished the protective effects of Sal A on lipotoxicity. Moreover, while AMPK silencing blocked Sal A-induced SIRT1, silencing of SIRT1 had no effect on Sal A-triggered AMPK activation, suggesting SIRT1 upregulation by Sal A is mediated by AMPK activation.Conclusion: Our data uncover a novel mechanism for hepatoprotective effects of Sal A against lipotoxicity both in livers from HFCD-fed mice and palmitic acid-treated hepatocytes.
Analysis of the Costs Associated With the Elective Evaluation of Patients Labelled as Allergic to Beta-Lactams or Nonsteroidal Antiinflamatory Agents
Authors: Sobrino-García Miriam , Moreno Esther M. , Muñoz-Bellido Francisco J. , Gracia-Bara Maria T. , Laffond Elena , Doña Inmaculada , Martín Cristina , Macías Eva M. , de Arriba Sonia , Campanón Valle , Gallardo Alicia , Dávila Ignacio 
Published: November 2020

Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive. We aimed to analyze different studies of the costs of drug hypersensitivity assessment.Methods: A bibliographic search on studies regarding this issue was performed, including the available scientific evidence up to June 2020. We searched three databases with terms related to costs and allergy testing in drug hypersensitivity reactions.Results: Our search revealed 1,430 publications, of which 20 met the inclusion criteria. In the manuscript, prospective studies evaluating the costs of the evaluation of patients with suspected allergy to beta-lactams or non-steroidal anti-inflammatory drugs are analyzed. Also, comment is made on the costs associated with incorrect labeling as non-steroidal anti-inflammatory drug or penicillin hypersensitivity.Conclusions: Taking all costs into account, the study of drug hypersensitivity is not expensive, particularly considering the economic and clinical consequences of labeling a patient with hypersensitivity to drugs.
Acupuncture for Improving Cognitive Impairment After Stroke: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhou Liang , Wang Yao , Qiao Jun , Wang Qing Mei , Luo Xun 
Published: November 2020

Objective: This meta-analysis evaluated the efficacy of acupuncture in improving cognitive impairment of post-stroke patients.Design: Randomized controlled trials (RCTs) investigating the effects of acupuncture compared with no treatment or sham acupuncture on post-stroke cognitive impairment (PSCI) before December 2019 were identified from databases (PubMed, EMBASE, Ovid library, Cochrane Library, Chinese National Knowledge Infrastructure, VIP Chinese Periodical Database, Wanfang Database, and SinoMed). The literature searching and data extracting were independently performed by two investigators. Study quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analyses were performed for the eligible RCTs with Revman 5.3 software.Results: Thirty-seven RCTs (2,869 patients) were included in this meta-analysis. Merged Random-effects estimates of the gain of MMSE (Mini-Mental State Examination) or MoCA (Montreal Cognitive Assessment) were calculated for the comparison of acupuncture with no acupuncture or sham acupuncture. Following 2–8 weeks of intervention with acupuncture, pooled results demonstrated significant effects of acupuncture in improving PSCI assessed by MMSE (MD [95% CI] = 2.88 [2.09, 3.66], p &lt; 0.00001) or MoCA (MD [95% CI] = 2.66 [1.95, 3.37], p &lt; 0.00001).Conclusion: The results suggest that acupuncture was effective in improving PSCI and supported the needs of more rigorous design with large-scale randomized clinical trials to determine its therapeutic benefits.
Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017
Authors: Clift Ashley Kieran , Coupland Carol AC , Hippisley-Cox Julia 
Published: November 2020

BackgroundProstate cancer is a leading cause of cancer- related death. Interpreting the results from trials of screening with prostate-specific antigen (PSA) is complex in terms of defining optimal prostate cancer screening policy.AimTo assess the rates of, and factors associated with, the uptake of PSA testing and opportunistic screening (that is, a PSA test in the absence of any symptoms) in England between 1998 and 2017, and to estimate the likely rates of pre-randomisation screening and contamination (that is, unscheduled screening in the ‘control’ arm) of the UK-based Cluster Randomised Trial of PSA Testing for Prostate Cancer (CAP).Design and settingOpen cohort study of men in England aged 40–75 years at cohort entry (1998–2017), undertaken using the QResearch database.MethodEligible men were followed for up to 19 years. Rates of PSA testing and opportunistic PSA screening were calculated; Cox regression was used to estimate associations.ResultsThe cohort comprised 2 808 477 men, of whom 631 426 had a total of 1 720 855 PSA tests. The authors identified that 410 724 men had opportunistic PSA screening. Cumulative proportions of uptake of opportunistic screening in the cohort were 9.96% at 5 years’, 22.71% at 10 years’, and 44.13% at 19 years’ follow-up. The potential rate of contamination in the CAP control arm was estimated at 24.50%.ConclusionA substantial number of men in England opt in to opportunistic prostate cancer screening, despite uncertainty regarding its efficacy and harms. The rate of opportunistic prostate cancer screening in the population is likely to have contaminated the CAP trial, making it difficult to interpret the results.
“E daí?”, afinal “Para que história?”
Authors: Bredariolli Rita Luciana Berti 
Published: November 2020

Não há retrocesso, somente a constelação de tempos heterogêneos saturados de agoras. Esse texto é dedicado a atos de resistência como reação, contrariedade, oposição, insubmissão, persistência, sobrevivência. Como matéria e atributo da história e da memória, potências de reconhecimento e reverberação desses modos de existência. Formas de atuação política. Sua escrita seguiu a atualização de uma pergunta designada, em 1983, como título de um texto em defesa da história e memória para a revitalização e fortalecimento de um campo de conhecimento dedicado à investigação das delicadas e potentes relações entre arte e educação: “Para que história?”
Potensi Seledri (Apium Graveolens L) Sebagai Antihipertensi
Authors: Naqiyya Nada 
Published: November 2020

Hipertensi merupakan masalah kesehatan dunia dan penyebab utama kematian dini di dunia. Prevalensi hipertensi di Indonesia terus meningkat dan pada tahun 2018 mencapai 34,1%. Hipertensi merupakan penyakit kardiovaskular yang ditandai dengan peningkatan tekanan darah sistolik ≥ 140 mmHg dan tekanan darah diastolik ≥ 90 mmHg. Hipertensi tidak mempunyai gejala khusus namun apabila terlambat dalam penanganannya dan tidak memperhatikan faktor risiko dapat menyebabkan komplikasi dan kematian organ target. Penatalaksanaan dalam hipertensi dapat dilakukan dengan pengobatan tradisional. Seledri merupakan tumbuhan yang dapat digunakan dalam pengobatan herbal hipertensi. Senyawa yang terkandung dalam seledri bersifat anti hipertensi seperti menurunkan kontraksi pembuluh darah dan menurunkan volume cairan ekstraseluler
ОСОБЛИВОСТІ МЕЛАТОНІНУТВОРЮВАЛЬНОЇ ФУНКЦІЇ ЕПІФІЗУ ТА ДИСЛІПІДЕМІЇ У ХВОРИХ НА ХРОНІЧНУ ХВОРОБУ НИРОК 5 Д СТАДІЇ
Authors: Petrova Anna 
Published: November 2020

Мета дослідження: проаналізувати мелатонінутворювальну функцію епіфізу (МФЕ) та показники ліпідного обміну крові хворих на хронічну хворобу нирок (ХХН) 5 Д стадії та визначати взаємозв’язок дисліпідемії з МФЕ.Матеріал і методи: Обстежено 130 осіб (50 % чоловіки) у віці 58,5 [43; 66] років, що знаходяться на постійному лікуванні гемодіалізом. Усім хворим проведені клініко-лабораторні дослідження: загальний та біохімічний аналізи крові з визначенням рівня холестерину та його фракцій, визначено денний та нічний рівень мелатоніну в слині методом імуноферментного аналізу, проведено вимірювання офісного артеріального тиску (АТ).Результати та обговорення: Виявлено значну поширеність порушення МФЕ у хворих на ХХН 5 Д стадії та його взаємозв’язок з ліпідним спектром крові. Визначено негативний кореляційний зв’язок нічного рівня мелатоніну з загальним холестерином (ЗХ) (r = -0,26; p < 0,05), негативний кореляційний зв’язок з тригліцеридами (ТГ) (r = -0,27; p < 0,05) та позитивний кореляційний зв’язок з ліпопротеїдами високої щільності (ЛПВЩ) (r = 0,33; p < 0,05). Отримано позитивний зв’язок ЛПВЩ та денного рівня мелатоніну (r = 0,27; p < 0,05) За аналізом результатів дослідження ліпідного метаболізму у пацієнтів на гемодіалізі відзначена наявність підвищеної концентрації загального ЗХ, ТГ, фракцій ліпопротеїдів низької щільності (ЛПНЩ) та низький вміст ЛПВЩ. Хворі з порушеною МФЕ в порівнянні з групою ІІ мають достовірно вищі рівні ЗХ, ТГ, ЛПНЩ та нижчі рівні ЛПВЩ.Висновки: Для хворих на ХХН 5Д ст., що лікуються методом гемодіалізу, притаманні виражені порушення ліпідного обміну (58%). У хворих на нирково – замісній терапії порушення ліпідного метаболізму асоційоване з мелатонінутворювальною функцією епіфізу, рівнями систолічного та діастолічного артеріального тиску, тривалістю артеріальної гіпертензії, рівнем гемоглобіну та тривалістю лікування гемодіалізу.
НАУКОВІ ЧИТАННЯ ПАМ’ЯТІ ПРОФЕСОРА А.П. ПЕЛЕЩУКА
Authors: Moyseyenko Valentina 
Published: November 2020

7 листопада 2019 р. у м. Києві відбулися V читання пам’яті заслуженого діяча науки УРСР, лауреата Державної премії УРСР, доктора медичних наук, професора Анатолія Петровича Пелещука. Під час роботи конференції відбулося обговорення широкого кола проблемних питань з різних напрямків внутрішньої медицини, а також етичних і правових засад діяльності лікарів у сучасних умовах.
Minding the Gap: GW190521 as a Straddling Binary
Authors: Fishbach Maya , Holz Daniel E. 
Published: November 2020

Abstract
Models for black hole (BH) formation from stellar evolution robustly predict the existence of a pair-instability supernova (PISN) mass gap in the range ∼50 to ∼120 solar masses. This theoretical prediction is supported by the binary black holes (BBHs) of LIGO/Virgo’s first two observing runs, whose component masses are well fit by a power law with a maximum mass cutoff at

. Meanwhile, the BBH event GW190521 has a reported primary mass of

, firmly above the inferred

, and secondary mass

. Rather than concluding that both components of GW190521 belong to a new population of mass-gap BHs, we explore the conservative scenario in which GW190521's secondary mass belongs to the previously observed population of BHs. We replace the default priors on m
1 and m
2, which assume that BH detector-frame masses are uniformly distributed, with this population-informed prior on m
2, finding

at 90% credibility. Moreover, because the total mass of the system is better constrained than the individual masses, the population prior on m
2 automatically increases the inferred m
1 to sit above the gap (39% for m
1 > 120

, or 25% probability for m
1 > 130

). As long as the prior odds for a double-mass-gap BBH are smaller than

, it is more likely that GW190521 straddles the pair-instability gap. We argue that GW190521 may be the first example of a straddling binary black hole, composed of a conventional stellar mass BH and a BH from the “far side” of the PISN mass gap.
Brachymna tenuis Stål, 1861 (Hemiptera: Pentatomidae), a new invasive bamboo pest in Korea with notes on insects associated with bamboos
Authors: Ahn Soojeong , Kim WonGun , Kim Sangsu , Cho Geonho 
Published: November 2020

We report first observations of the invasive bamboo pest,Brachymna tenuisStål, 1861 in Korea as the first species ofBrachymnaStål, 1861 (Pentatomidae) reported from the country.Comments on its pest status and distribution are provided. General information on this bamboo-feeding insect in Korea is analysed and provided for the first time.
Writing Multiple-Choice Test Items That Promote and Measure Critical Thinking
Authors: Morrison Susan , Free Kathleen Walsh 
Published: November 2020

ABSTRACT
Faculties are concerned about measurement of critical thinking especially since the National League for Nursing Accrediting Commission cited such measurement as a requirement for accreditation (NLNAC, 1997). Some writers and researchers (Alfaro-LeFevre, 1995; Blat, 1989; McPeck, 1981, 1990) describe the need to measure critical thinking within the context of a specific discipline. Based on McPeck's position that critical thinking is disciplinespecific, guidelines for developing multiple-choice test items as a means of measuring critical thinking within the discipline of nursing are discussed. Specifically, criteria described by Morrison, Smith, and Britt (1996) for writing CTitical-thinking multiple-choice test items are reviewed and explained for promoting and measuring critical thinking.
Faculty Perceptions of Teaching Nursing Content Online in Prelicensure Baccalaureate Nursing Programs
Authors: Puksa Micki M. , Janzen Katharine 
Published: November 2020

Background:
The purpose of this study was to explore the perceptions of nursing faculty regarding the nature, challenges, and strengths of teaching course content online in prelicensure collaborative baccalaureate nursing programs and the implications for online course delivery.

Method:
This was an exploratory–descriptive, mixed-methods design based on document analysis, an online survey completed by 32 faculty, and interviews with 16 faculty in a representative sample of 13 English speaking colleges in Ontario.

Results:
Participants perceived content containing complex cognitive concepts, experiential learning as in relational practice, and psychomotor skill mastery as better suited for traditional classroom delivery. Faculty identified challenges with developing higher level online discussions and having students collaborate.

Conclusion:

Online teaching took much more time and should be acknowledged in workload assignments. A hybrid teaching environment was preferred. Online education was useful when the content and the semesters/years were appropriate, and necessary supports were in place.

[
J Nurs Educ
. 2020;59(12):683–691.]
O sangue puro em Harry Potter e seus ecos dialógicos eugênicos
Authors: Paula Luciane De , Siani Ana Carolina 
Published: November 2020

Embasado na perspectiva bakhtiniana da linguagem, a partir da constituição socioideológica da arte, este artigo propõe tecer uma análise dialógica acerca do discurso da “pureza da raça”, como conteúdo temático materializado na narrativa de Harry Potter (HP), expresso pela voz vilanesca, especialmente pelos posicionamentos axiológicos de Voldemort. O objetivo é pensar sobre como o signo ideológico transita da vida para a arte e da arte volta à vida. A justificativa se volta à relevância de se pensar, a partir da arte (HP), acerca do racismo científico e da eugenia propagados e existentes na vida, mobilizados como arma política pelo nazismo e como valoração axiológica da “pureza”, em diálogo, atribuído pelos fãs da saga, ao discurso bolsonarista. Os resultados confirmam a premissa da qual se parte, de que os valores preconceituosos e de intolerância com as diferenças na série mágica em interação com a contemporaneidade, em embate com o portal Potterish, que defende os direitos humanos, ocorre, de maneira refletida e refratada entre arte e vida, na obra Harry Potter.Palavras-chave: Harry Potter; Eugenia; Dialogismo; Estudos Bakhtinianos.