bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Quantitative Comparison of Inhibitory Interneuron Size and Distribution between Mouse and Macaque V1, Using Calcium-Binding Proteins
Authors: Kooijmans Roxana N , Sierhuis Wesley , Self Matthew W , Roelfsema Pieter R 
Published: September 2020

AbstractThe mouse is a useful and popular model for studying of visual cortical function. To facilitate the translation of results from mice to primates, it is important to establish the extent of cortical organization equivalence between species and to identify possible differences. We focused on the different types of interneurons as defined by calcium-binding protein (CBP) expression in the layers of primary visual cortex (V1) in mouse and rhesus macaque. CBPs parvalbumin (PV), calbindin (CB), and calretinin (CR) provide a standard, largely nonoverlapping, labeling scheme in macaque, with preserved corresponding morphologies in mouse, despite a slightly higher overlap. Other protein markers, which are relevant in mouse, are not preserved in macaque. We fluorescently tagged CBPs in V1 of both species, using antibodies raised against preserved aminoacid sequences. Our data demonstrate important similarities between the expression patterns of interneuron classes in the different layers between rodents and primates. However, in macaque, expression of PV and CB is more abundant, CR expression is lower, and the laminar distribution of interneuron populations is more differentiated. Our results reveal an integrated view of interneuron types that provides a basis for translating results from rodents to primates, and suggest a reconciliation of previous results.
La Convention de Vienne du 11 avril 1980 et la pratique arbitrale : expérience dans un nouvel État adhérent
Authors: Do Van Dai 
Published: September 2020

Résumé:
Année après année, il y a de nouvelles accessions à la Convention de Vienne. Du fait que les arbitres n’ont pas de for étatique, il est intéressant de comprendre ce que font les arbitres dans les nouveaux pays adhérents lorsqu’ils sont saisis d’une vente internationale de marchandises. Apportant un intérêt non négligeable pour les acteurs du commerce international qui ont les contrats de vente avec ces pays, pour l’effectivité de la Convention et pour les États nouveaux membres de la Convention, la présente étude aborde l’applicabilité, la mise en œuvre et le traitement des lacunes de la Convention devant les arbitrages dont le lieu se trouve dans un nouvel État adhérent, à savoir le Vietnam.
Effect of Disrupted Rehabilitation Services on Distress and Quality of Life in Breast Cancer Survivors During the COVID-19 Pandemic
Authors: Helm Erin E. , Kempski Katelyn A. , Galantino Mary Lou A. 
Published: September 2020

Background:
Cancer rehabilitation often includes manual assessment and interventions to address cancer treatment–related side effects. The effect of reduced access to rehabilitative care due to COVID-19 is currently unknown.

Objective/Purpose:
To assess distress and quality of life (QOL) for women receiving care for breast cancer–related impairments during closure of rehabilitation services due to COVID-19.

Methods:
Preexisting patients returning to rehabilitation services after a COVID-19–associated interruption of treatment were asked to complete a survey regarding their distress, function, and QOL levels at the suspension of rehabilitation services and at the resumption of those services.

Setting and Patients:
Outpatient cancer rehabilitation clinic treating breast cancer survivors at an accredited cancer center.

Measurements:
Distress thermometer, FACT-G (Functional Assessment of Cancer Therapy–General) survey, and visual analog scale questions regarding sleep, fatigue, and physical activity as part of reassessment by the clinician. Utility of telehealth was also explored.

Results:
Fifteen women (age range, 38-76 years) with primary complaints of shoulder stiffness, pain, and lymphedema completed surveys, and 33% received telehealth. Reported distress levels at the time of closure were significantly higher than self-reported levels at reopening (t
14 = 4.69, P = .000). Increases in distress at the time of closure were correlated with reduced physical activity (r = −0.602, P = .018). Reduced levels of distress following return to rehabilitation were correlated with reduced levels of fatigue (r = 0.575, P = .025). No statistically significant relationships between distress and sleep quality were found.

Limitations:
Self-report via surveys, recall bias, and the multifactorial characteristics of distress limit study findings.

Conclusion:
Closure of rehabilitation services during COVID-19 created distress, resulting in reduced physical activity and QOL in breast cancer survivors. Cancer survivorship communities will need to assess the effect of disrupted service across cancer rehabilitation centers. Further research is needed to validate optimal interventions including telehealth best practice to manage distress and QOL in a COVID-19 context.
Diagnosis and Treatment of Chronic Lymphocytic Leukemia: Recommendations of the French CLL Study Group (FILO)
Authors: Quinquenel Anne , Aurran‐Schleinitz Thérèse , Clavert Aline , Cymbalista Florence , Dartigeas Caroline , Davi Frédéric , de Guibert Sophie , Delmer Alain , Dilhuydy Marie‐Sarah , Feugier Pierre , Fornecker Luc‐Matthieu , Ghez David , Guieze Romain , Laribi Kamel , Leblond Véronique , Leprêtre Stéphane , Letestu Rémi , Lévy Vincent , Nguyen‐Khac Florence , Michallet Anne‐Sophie , Tomowiak Cécile , Tournilhac Olivier , Ysebaert Loïc , Troussard Xavier ,   FILO‐LLC Group
Published: September 2020

AbstractAs a result of significant recent developments, the management of patients with chronic lymphocytic leukemia (CLL) is changing, and new therapeutic options will continue to emerge in the near future. The recommendations of the French Innovative Leukemia Organization (FILO‐CLL) group presented here are intended to provide practical recommendations for physicians taking care of CLL patients, taking into account the availability of both biological tests and therapies in daily practice in France at the time of publication. This text details the documented information and guidelines on diagnosis, indications for treatment, infectious complications and therapeutic strategies in frontline and relapsed CLL as well as in particular conditions such as autoimmune cytopenia or Richter syndrome.
Interventions to improve physical performances of older people with cancer before complex medico-surgical procedures
Authors: Falandry Claire , Stefani Laetitia , Andre Louise , Granger Marion , Barbavara Claire , Habchi Hocine , Bourgeois Chrystelle , Cure Hervé , Passot Guillaume , Gilbert Thomas 
Published: September 2020

Abstract

Background:
Current demographics lead increasing older cancer patients to undergo complex medico-surgical procedures, with substantial risk of decompensations and deconditioning. The Prehabilitation & Rehabilitation in Oncology: Adaptation to Disease and Accompaniment of Patients’ Trajectories (PROADAPT) project is currently being developed with the aim of improving care, through standardized care pathways guided by existing evidence and implementation programs. A working group will specifically focus on improvement of physical performances before such procedures. These interventions may have been developed in different contexts: before surgery in large, before carcinologic surgery or complex medical interventions (chemotherapy, radiotherapy), or in primary care for elderly patients to prevent sarcopenia and frailty. Post-surgical interventions are out of the scope of this review. The objective of this review is to summarize the level of evidence to support physical reconditioning interventions and identify areas where further work is required.

Methods:
This umbrella review will include moderate to high quality systematic reviews, meta-analysis, and pre-existing umbrella or meta-reviews. Two reviewers will independently search the following databases: PubMed/MedLine, Cochrane Library, Embase, and CINAHL. Research strategy will use diverse keywords used to refer to the concepts of “prehabilitation,” “preoperative exercise,” or “preoperative rehabilitation,” with prespecified inclusion and exclusion criteria and only systematic reviews selection. The distinct types of interventions presented using PRISMA guidelines and a narrative reporting of results. A focus will be made on outcomes such as physical performances, quality of life, autonomy in everyday activities, or number of hospital bed days.

Ethics and dissemination:
Ethical approval is not required for such an umbrella review. Our review will be submitted for publication in a peer-reviewed international journal using open access option if available. It will be complementary to reviews focused on hospital discharge of older people.

PROSPERO registration number:
CRD42020100110.
A gene missense mutation in diffuse pulmonary lymphangiomatosis with thrombocytopenia
Authors: Zheng Guixian , Tang Haijuan , Su Rui , Liang Yi , He Zhiyi , Zhang Jianquan , Deng Jingmin , Bai Jing , Zhong Xiaoning 
Published: September 2020

Abstract

Introduction:
Diffuse pulmonary lymphangiomatosis (DPL) is a rare condition. Most patients with DPL present dyspnea, cough, expectoration, and hemoptysis. There are few reports of DPL accompanied by thrombocytopenia, whose cause remains unknown.

Patient concerns:
An 18-year-old male patient presented with recurrent cough, expectoration, and dyspnea for 5 years, and thrombocytopenia was observed during a 2-month follow-up.

Diagnosis:
Chest computed tomography showed diffuse patchy shadows in both lungs, and pleural and pericardial effusions. Immunohistochemical lung tissue staining showed lymphatic and vascular endothelial cells positive for D2-40, CD31 and CD34. Routine blood test revealed platelets at 62 × 109 cells/L during follow-up. Bone marrow biopsy was normal. Ultrasound revealed no hepatosplenomegaly. Finally, the patient was diagnosed with DPL accompanied by thrombocytopenia.

Interventions:
He was treated by subtotal pericardial resection, thoracocentesis, and anti-infective therapy. Oral prednisone was administered for 2 months.

Outcomes:
The symptoms of cough and shortness of breath were improved, but thrombocytopenia persisted. We investigated the cause of thrombocytopenia. Whole-exome sequencing identified a mutation in exon 3 of the TNFRSF13B gene in this patient.

Conclusion:
DPL may present with thrombocytopenia and DIC. Patients with thrombocytopenia but not DIC and splenomegaly should be screened for gene mutations.
Auricular acupuncture for premature ovarian insufficiency
Authors: Luo Yehao , Xu Donghan , Tang Xiusong , Wei Luqiu , Wang Lizhen , Pang Yuzhou , Fang Gang 
Published: September 2020

Abstract

Background:
A lot of attention has been given to premature ovarian insufficiency (POI) as it poses considerable health risks to women. It is characterized by oligomenorrhea, amenorrhea, infertility, autoimmune disorders, and ischemic heart disease, with increased mortality. Previous research indicates that auricular acupuncture is proven effective in treating POI in clinical practice. However, systematic review has not been carried out. Therefore, this study aims at evaluating the curative effect and safety of auricular acupuncture treatment for POI through systematic review and meta-analysis.

Methods and analysis:
The following databases will be searched for relevant information before August 2020: PubMed, Embase, Cochrane Library, Web of Science, and CNKI. Major results: levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estrogen (E2). Secondary results: modified Kupperman Index, imaging results including ovarian size, antral follicle count, and blood flow changes in the ovary using color Doppler ultrasound; total effective rate, adverse event and intervention, and hospitalization expenses. Data will be collected independently by 2 researchers, and the risk of bias in meta-analysis will be evaluated according to “Cochrane Handbook for Systematic Reviews of Interventions”. All data analysis will be conducted using Review Manager V.5.3. and Stata V.12.0.

Results:
The curative effect and safety of auricular acupuncture treatment for POI patients will be evaluated systematically.

Conclusion:
In the systematic review, the published evidence of auricular acupuncture treatment for POI will be summarized to provide guidance for promotion and application.

Ethics and dissemination:
The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.
Open Science Framework (OSF) registration number: http://osf.io/tg9mw
Application of pigtail catheter tailing combined with long-wire swapping technique in cerebral angiography via the right radial artery
Authors: Yan Dan , Zhu Bifeng , Li Qin , Peng Tao , Jiang Jingfang , Liu Jianlin , Dan Bitang 
Published: September 2020

Abstract
The safety and feasibility of transradial approach for cerebral angiography has been confirmed previously. However, this approach has been limited used due to the difficulty during the procedure. This study aimed to introduce a pigtail catheter tailing and long-wire swapping technique to improve the success rate without increasing complications.
From August 2015 to December 2018, 560 patients who underwent cerebral angiography via transradial approach were recruited. The data including the type of aortic arch, type of Simmon catheter were collected.
The loop was successfully constructed in 553 patients using Simmon-2 or Simmon-1 catheter. Of these patients, 72 patients successfully underwent cerebral and renal angiography, while 481 patients underwent cerebral angiography. The time for angiography was 52.87 ± 11.23 minutes and 47.8 ± 11.8 minutes, respectively. There were 369 (66.7%), 135 (24.4%), and 49 (8.9%) patients with type I, type II, and type III aortic arches, respectively, and their success rates of looping using Simmon-2 catheter were 97.8%, 97.0%, and 89.8%, respectively. The success rates of angiography in the right internal carotid artery, right vertebral artery, left internal carotid artery, and left vertebral artery were 100%, 100%, 98.9%, and 98.9%, respectively. No serious complications were observed in all patients.
The pigtail catheter tailing and long guidewire swapping is considered as a safe procedure with high success rate for loop construction using a Simmon-2 catheter through the right radial artery, subsequently improving the success rate as well as the efficiency of angiography.
Effects of Guizhi decoction for diabetic cardiac autonomic neuropathy
Authors: Chen Junmin , Cai Jiawei , Wei Mengya , Zhang Xiaoran , Zhong Min , Liu Min , Yu Yang , Chen Qiu 
Published: September 2020

Abstract

Background:
Diabetic cardiac autonomic neuropathy (DCAN) is one of the serious complications of diabetes. The pathogenesis of DCAN has not been fully elucidated. There is currently no effective treatment for such chronic disease. Traditional Chinese medicine has a long clinical history for the prevention and treatment of diabetes and chronic complications, and it also shows certain advantages in the treatment of DCAN. Many clinical studies have confirmed that Chinese medicine Guizhi decoction can reduce the clinical symptoms and improve neuronal function of patients with DCAN. So we intend to conduct a systematic review further clarified the effectiveness and safety of Guizhi decoction for DCAN.

Methods:
We will search each database from the built-in until July 2020. The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science, while the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Simultaneously we will retrieval clinical registration tests and grey literatures. In this study, only the clinical randomized controlled trials (RCTs) were selected to evaluate the efficacy and safety of Guizhi decoction in the treatment of DCAN. The 2 researchers independently conducted literature selection, data extraction, and quality assessment. Statistical heterogeneity among studies will be evaluated using the Cochran Q test (x2) and the I
2 statistical value. We will utilize the Review Manage software V5.3.0 (The Nordic Cochrane Center, The Cochrane Collaboration, 2014, Copenhagen, Denmark) to statistically analyze all data.

Ethics and dissemination:
This study is a protocol for a systematic review of Guizhi decoction as a treatment of DCAN patients.

Results:
This study will provide high-quality synthesis of effectiveness and safety of Guizhi decoction for DCAN.

Conclusion:
This systematic review aims to provide new options for Guizhi decoction treatment of DCAN in terms of its efficacy and safety.

Registration number:
INPLASY202080018.
Fabry disease with early-onset ventricular dilation
Authors: Tang Jia , Wu Chao , Cao Jian , Wang Liang 
Published: September 2020

Abstract

Rationale:
The most common cardiac involvement of Fabry disease (FD) is left ventricular hypertrophy (LVH), which usually occurs in male patients over the age of 30. In rare cases, it can progress to ventricular dilation in the late stage of the disease.

Patient concerns:
A 16-year-old boy presenting with recurrent extremity pain and chest distress was admitted to our hospital. Imaging examinations revealed ventricular dilation.

Diagnosis:
α-Galactosidase A enzyme assay and GLA gene sequencing confirmed the diagnosis of FD and revealed a novel mutation c.76_77insT.

Interventions:
The patient was treated using metoprolol (23.75 mg qd) and angiotensin-converting enzyme inhibitor (fosinopril sodium 5 mg qd). He refused enzyme replacement therapy for financial reasons.

Outcomes:
The echocardiography, electrocardiography, renal function, and routine blood and urine tests performed 20 months after the patients discharge from hospital showed no significant changes. The patient reported a slow and gradual decrease in the frequency and degree of pain and chest distress, starting approximately 24 months after discharge.

Lessons:
Cardiac involvement of FD can progress rapidly in some cases. Screening for FD should be considered in patients with unexplained ventricular dilation, especially in those with a history of typical FD manifestations.
Ankle distraction arthroplasty for the treatment of severe ankle arthritis
Authors: Liu Xiao-Ning , Chang Fei , Zhang Han-Yang , Zhong Zhuan , Xue Pan , Huang Bing-Zhe 
Published: September 2020

Abstract

Rationale:
Widely applied in the treatment of severe ankle arthritis (AA), ankle distraction arthroplasty (ADA) can avoid not only the ankle range of motion loss but also ankle fusion. However, the clinical outcomes of ADA for severe AA are poorly understood. This study aims to present our clinical outcomes of severe AA treated by ADA.

Patient concerns:
A 53-year-old man suffered right ankle sprain 10 years ago, endured right ankle pain and limited movement for 6 years.

Diagnosis:
The patient was diagnosed as severe AA.

Interventions:
He received ankle distraction arthroplasty. No adjuvant procedures were performed. The visual analog scale (VAS), the American Orthopaedic Foot and Ankle Society (AOFAS) score, the short-form (SF)-36 physical component summary (PCS) score and ankle activity score (AAS) were recorded to access the clinical outcomes pre- and postoperatively. Moreover, ankle joint space distance was evaluated on weight-bearing radiographs.

Outcomes:
The patient derived effective pain relief and restored a satisfactory range of movement. There was a 13-month follow-up period after frame removal. The AOFAS score improved from 56 preoperatively to 71 postoperatively. The VAS score decreased from 6 prior to surgery to 1 after surgery. The SF-36 PCS was 47.2 and 71.8 pre- and postoperative, respectively. The AAS scores were improved from 3.4 preoperatively to 7.3 postoperatively.

Lessons:
ADA is reliable to achieve pain relief, functional recovery, and serve AA resolution. Besides, it is an alternative to ankle arthrodesis or total ankle arthroplasty in selected patients with severe AA.
Goodpasture syndrome manifesting as nephrotic-range proteinuria with anti-glomerular basement membrane antibody seronegativity
Authors: Zhong ZhengXia , Tan JiaXing , Tang Yi , Li ZhengFu , Qin Wei 
Published: September 2020

Abstract

Rationale:
The Goodpasture syndrome is an extremely rare disease, with renal and pulmonary manifestations, and is mediated by anti-glomerular basement membrane (anti-GBM) antibodies. Renal pathological changes are mainly characterized by glomerular crescent formation and linear immunofluorescent staining for immunoglobulin G on the GBM. There are few reports on the atypical course of the syndrome involving serum-negative anti-GBM antibodies. Therefore, we present a case of Goodpasture syndrome that presented with nephrotic-range proteinuria and was seronegative for anti-GBM antibodies.

Patient concerns:
A 38-year-old Chinese man presented with a lung lesion that was discovered by physical examination a month prior to presentation. The chief concern was occasional hemoptysis without fever, cough, chest pain, and edema.

Diagnoses:
Laboratory testing revealed that the urinary protein level and urine erythrocyte count were 7.4 g/24 hours and 144/high-power field (HPF), respectively. Serological testing for anti-GBM antibodies was negative. Chest computed tomography revealed multiple exudative lesions in both lungs, indicating alveolar infiltration and hemorrhage. Electronic bronchoscopy and pathological examination of the alveolar lavage fluid indicated no abnormalities. However, kidney biopsy suggested cellular crescent formation and segmental necrosis of the globuli, with linear IgG and complement C3 deposition on the GBM. These findings were consistent with the diagnosis of anti-GBM antibody nephritis.

Interventions:
The patient underwent 7 sessions of double filtration plasmapheresis. He was also administered with intravenous methylprednisolone and cyclophosphamide. After renal function stabilization, he was discharged under an immunosuppressive regimen comprising of glucocorticoids and cyclophosphamides.

Outcomes:
Three months later, follow-up examination revealed that the 24-hour urine protein had increased to 13 g. Furthermore, the urine erythrocyte count was 243/HPF. After a 6-month follow-up, the patient achieved partial remission, with a proteinuria level of 3.9 g/24 hours and a urine erythrocyte count of 187/HPF.

Lessons:
This extremely rare case of Goodpasture syndrome manifested with seronegativity for anti-GBM antibodies and nephrotic-range proteinuria. Our findings emphasize the importance of renal biopsy for the clinical diagnosis of atypical cases. Furthermore, because renal involvement achieved only partial remission despite therapy, early detection and active treatment of the Goodpasture syndrome is necessary to improve the prognosis of patients.