bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДІАГНОСТИКА ТАКСАН-ІНДУКОВАНОЇ ПЕРИФЕРИЧНОЇ НЕЙРОПАТІЇ У ОНКОЛОГІЧНИХ ХВОРИХ
Authors: Голотюк І. С. , Крижанівська А. Є. , Голотюк В. В. , Андріїв А. В. , Голотюк С. І. 
Published: October 2020

Резюме. На даний час немає стандартизованого підходу до клінічної оцінки хіміотерапевтично-індукованої нейропатії. Однак існує консенсус у тому, що діагностика хіміотерапевтично-індукованої периферичної нейропатії повинна включати в себе як об’єктивні ознаки неврологічних розладів, так і оцінку симптомів з точки зору пацієнта. Причиною саме такого підходу є розбіжності у результатах клінічного обстеження та самооцінкою пацієнтами важкості свого стану. Зазвичай дані клінічного обстеження пацієнтів недооцінюють важкість побічних реакцій під час хіміотерапії. Діагностика хіміотерапевтично-індукованої периферичної нейропатії включає в себе опитувальники, оціночні шкали та об’єктивні методи дослідження нейрофізіологічних змін периферичної нервової системи, такі як електроміографія та кількісне сенсорне тестування. Оціночна шкала повинна володіти широким спектром показників, до яких входять клінічні симптоми, об’єктивні ознаки втрати чутливості та нейрофізіологічні параметри. Не менш актуальним є анкетування із самооцінкою свого стану пацієнтами в рамках клінічного дослідження. Включення оцінок, отриманих безпосередньо від пацієнтів, дозволяє провести більш комплексне та детальне вивчення хіміотерапевтично-індукованої периферичної нейропатії, удосконалює розуміння впливу симптомів нейропатії на пацієнтів та покращує узгодженість даних об’єктивного обстеження із результатами оцінки фукціональних змін.
Хіміотерапевтично-індуковану периферичну нейропатію необхідно диференціювати із нейропатіями іншого генезу, зокрема діабетичною та паранеопластичною нейропатіями. Запорукою своєчасної диференціальної діагностики є ретельне обстеження пацієнтів до початку хіміотерапії нейротоксичними препаратами з метою виявлення передіснуючої нейропатії.
РЕЗУЛЬТАТИ ЛІКУВАННЯ ГІПЕРЕСТЕЗІЇ ЗУБІВ ІЗ КОМБІНОВАННИМ ВИКОРИСТАННЯМ НИЗЬКОІНТЕНСИВНОГО ЛАЗЕРНОГО ВИПРОМІНЮВАННЯ ТА АПІПРОДУКТІВ
Authors: Демидова П. І. , Рябоконь Є. М. 
Published: October 2020

Резюме. Однією з причин виникнення гіперестезії зубів є наявність у пацієнтів різних ступенів розвитку генералізованого пародонтиту. Для отримання довготривалих результатів у зниженні показників гіперестезії зубів, необхідно оптимізувати наявні методи лікування.
Метою дослідження було оцінити ефективність лікування гіперестезії зубів у хворих на генералізований пародонтит хронічного перебігу із використанням низькоінтенсивного лазерного випромінювання та апіпродуктів.
104 хворих на генералізований пародонтит хронічного перебігу та гіперестезією зубів було розділено на 4 групи відповідно до отриманого методу лікування. Ступінь вираженості чутливості гіперестезії зубів оцінювали за шкалою Schiff. У 1 групі використовували лак на основі фториду натрію, у 2 –настойку прополісу, в 3 – низькоінтенсивне лазерне випромінювання з довжиною хвилі 810 нм, у 4 групі лікування проводилося за допомогою комбінованого використання настойки прополісу та низькоінтенсивного лазерного випромінювання з довжиною хвилі 810 нм. Отримані значення показників за шкалою Schiff оцінювали до лікування, одразу після лікування, через тиждень, 1 місяць, 3 місяці, пів року та рік після лікування. Статистичну достовірність результатів оцінювали у IBM SPSS Statistics, V. 25.0 (Armonk, NY: IBM Corp.).
Лікування було ефективним одразу після його отримання в кожній з груп, про що свідчить значне зниження середніх значень показників за шкалою Schiff; через рік найнижчі значення були отримані у четвертій групі. Результати порівняння між групами є статично значущими (р <0,05).
Аналіз отриманих результатів показників оцінки ефективності запропонованого методу лікування гіперестезії зубів свідчить про високу клінічну стійкість та довготривалість отриманого ефекту.
ДОСВІД НАДАННЯ ХІРУРГІЧНОЇ ДОПОМОГИ ХВОРИМ З РОЗРИВОМ АНЕВРИЗМ ІНФРАРЕНАЛЬНОГО ВІДДІЛУ АОРТИ
Authors: Десятерик В. І. , Давиденко О. В. , Слободянюк В. А. , Желізняк В. Г. , Прокуда О. М. 
Published: October 2020

Були представлені результати аналізу хірургічного лікування 22 пацієнтів з розривом аневризми черевного відділу аорти за період 2015-2019 роки. чоловіків - 15,жінок -7. Вік коливався 57-82 років, переважна більшість хворих-17(77%) в віці 59-65 років. За етіологічними чинниками частіше ( в 20 випадках) відмічено атеросклеротичне ураження аорти в співвідношенні з гіпертонічною хворобою, в 1 випадку в анамнезі мінно-вибухова травма в збройному конфлікті АТО, в другому операція на простаті та променева терапія 8 років потому. З моменту прояву перших симптомів захворювання до вступу в стаціонар пройшло від 4 до 96 годин. Всі хворі при надходженні до стаціонару були обстежені на УЗД , 9 хворим крім того виконано СКТ обстеження. Частіше нами виявлені мішкоподібні аневризми -16,веретеноподібні-6.Задовільний результат відзначений в 16 (69,5%) хворих цією патологією. Різноманітні ускладнення виникли в 7 (30,4%) хворих. Летальність склала 7 випадків (30,4%).
Remaining an Outsider. An Eighteenth-Century Diary of a Hungarian Nobleman
Authors: Csikós Gábor 
Published: October 2020

György Nagy was an eighteenth-century merchant and nobleman in the Jászság region, and his diary for the period 1759 to 1769 gives insights into his selfidentity. Even though it is not explicitly stated, the document is infused with a sense of being an outsider. This study attempts to find the bases of this sentiment using the methods of cultural psychology, and seeks to explore his particular responses to conflicts that arose in his life. Four factors can be identified which made the diary’s author an outcast: (i) Nagy came from outside the Jászság region; (ii) his university-level education and profession distinguished his lifestyle from that of the landed peasant majority; (iii) his identity as a member of lower nobility; (iv) the conjunction and combination of these circumstances all at once. It was Nagy’s ancestry which was the principal determinant his self-image and exercised the greatest influence over his decisions (loans, etc.).
Helen Southworth. Fresca. A Life in the Making. A Biographer’s Quest for a Forgotten Bloomsbury Polymath
Authors: Van Duijn Heleen 
Published: October 2020

The subject of Southworth’s book is Francesca (Fresca) Allinson (1902–1945), a puppeteer, choral conductor, writer and creator of folksongs, whose life was cut short by drowning. She grew up in a gifted and thoroughly non-conformist family. Her brother Adrian, a painter, studied at the Slade school. Her father worked as a doctor at his practice in London, obtaining and practising his own unorthodox convictions about hygiene and diet. As a radical pacifist Fresca helped provide alternative communities for conscientious objectors (COs). Her fictional autobiography A Childhood was published in 1937, by the Hogarth Press, the publishing house of Leonard and Virginia Woolf.
Joaquín Sánchez Macgrégor, Dialéctica de la unidad y la diferencia en un contexto latinoamericano, México, Plaza y Valdés/CCyDEL-UNAM, 2003, 100 pp. (Col. Democracia y Cultura)
Authors: Soley Tonatiuh 
Published: October 2020

Reseña del libro: Joaquín Sánchez Macgrégor, Dialéctica de la unidad y la diferenciaen un contexto latinoamericano, México, Plaza yValdés/CCyDEL-UNAM, 2003, 100 pp. (Col. Democracia y Cultura)
Homenaje a Leopoldo Zea, México, CCyDEL-FFyLCoordinación de Humanidades-UNAM, 2006, 270 pp.
Authors: Hurtado Guillermo 
Published: October 2020

Reseña del libro: Homenaje a Leopoldo Zea, México, CCyDEL-FFyLCoordinación de Humanidades-UNAM, 2006, 270 pp.
Hilda Naeseens, Una “visión continentalista” de la filosofía: José Gaos y Francisco Romero, México, UNAM, 2007, 186 pp.
Authors: Sánchez López Hugo Enrique 
Published: October 2020

Reseña del libro: Hilda Naeseens, Una “visión continentalista” de la filosofía:José Gaos y Francisco Romero, México, UNAM,2007, 186 pp.
Prevalence of Musculoskeletal Disorders in Gardeners.
Authors: Rushikesh Rajendra Mangale  , Dr. Smita Chandrakant Patil  , Dr. Chandrakant Babaso Patil  , Dr. Khushboo Trishant Chotai  
Published: October 2020

Musculoskeletal disorders are a group of disorders that affect the musculoskeletal system involving the nerves, tendons and ligaments as well. Musculoskeletal disorders are emerging common health problems among workers due to intensive manual work. They include shoulder pain, tenosynovitis, carpal tunnel syndrome etc..Occupations with prolonged work hours and repetitive tasks are one of the main reasons for development of abnormal posture and micro injury to the muscles. Gardening is a profession where multiple positions are assumed that are required to be maintained over long periods of time eg squatting position or trunk bent position. Also, repetitive movements of the wrist and hand are used. Gardening is also a profession which has not been given much attention by the medical field and hence their postural and muscular abnormalities which are a result of labour intensive and cumbersome work are often overlooked. These problems can easily be dealt with if proper physiotherapy is done. Therefore, keeping in mind the workload of this target group. it is important to rule out the musculoskeletal abnormalities faced by them. So the present study was conducted with the aim to determine prevalence of musculoskeletal disorder among women gardeners. An observational study was conducted in 60 female gardeners at Krishna hospital Karad. Only women within the age group of 20-60 years were involved. As the outcome measure, visual analogue scale (VAS) was used to rate the intensity of pain or discomfort experienced by the gardeners. They were presented with a standard VAS and asked to mark their perceived amount of discomfort. Nordic pain questionnaire was also used to determine the sites of pain and also the duration of symptoms. The results of the study indicated that lower back pain was more prevalent in female gardeners of Krishna Hospital which is attributed to the nature of their work followed by neck problem 43.33%, knee problem 40%, wrist problem 31.66%, and shoulder problem 28.33%. Therefore it can be concluded that musculoskeletal disorders are prevalent in female gardeners with low bak pain being the most common.
Characterization of Purified Collagen from Marine Squid Uroteuthis Duvauceli
Authors: Jency George  , Dr. Manjusha W. A.  
Published: October 2020

Collagen is the essential and most abundant structural protein found in the animal kingdom, involving almost 25-30% of the entire body protein content. It is normally found in fibrous tissues, for example, skin, tendons, ligaments, skin, corneas, ligament, bones, veins, teeth, and so on. The skin of the squid is rich in collagen and is an excellent source of raw materials that can be used for the development of collagen products. As such, the use of Uroteuthis duvauceli skin is an alternative source of collagen may be an effective way to obtain high-value-added products. In this study, - the isolated Type 1 collagen was found in Uroteuthis duvauceli (skin and muscle ). Additionally, the characterization of the Type 1 collagen from Uroteuthis duvauceli (skin and muscle ) was examined through various techniques such as SEM, FTIR, XRD, TGA. The skin and muscle showed the typical SDS-PAGE pattern of type I collagen with two different α bands, α1 and α2 and also contains β and γ chains. The fibrillar structures of collagen samples were observed by SEM. FTIR investigation showed the existence of helical arrangements of the type 1 collagen from skin and muscle. UV spectrum of Type1 collagen from Uroteuthis duvauceli skin and muscle has a maximum absorption peak near 230 nm and a minor absorption peak near 280 nm. In XRD, type1 collagen from Uroteuthis duvauceli skin and muscle one wide peak was obtained following with characteristic diffraction peaks of collagen. The results showed that type 1 collagen from skin and muscle had slight differences in molecular weight, amino acid composition, morphological structures, and thermal stability. The present data on collagens from the marine squid, could help the future endeavors to unwind the therapeutically significant, more secure collagens from marine squid for their utilization in biomedical field.
Haematological Assessment of Methanolic Stem Extract of Cissus quadrangularisLinn. against Freund's Complete Adjuvant induced Female Albino Arthritic Rats
Authors: S. Shamina  , Anjana  , S. Suja  
Published: October 2020

Rheumatoid arthritis is a chronic, inflammatory and autoimmune disorder. Rheumatoid arthritis is a joint destruction which occurs due to increased expression of cytokines and transcription factors. Cissus quadrangularis belongs to the Vitaceae family. The plant shows anti-osteoporotic, anti-inflammatory and anti-microbial properties. Soxhlet method was used for the extraction of the plant using methanol as a solvent. The anti-arthritic activity of methanolic extract of Cissus quadrangularis was evaluated by in vivo study. The present study assess the haematological parameters in female albino rats after the induction of Freund's Complete Adjuvant. Dexamethasone was used as the standard reference drug. The study showed varied changes in the haematology after the arthritic induction by 0.1 ml FCA which were analyzed before and afterthe treatment period. The inhibition of secondary inflammation in adjuvant arthritic rats by methanolic extract of Cissus quadrangularis was studied by haematological parameters. The total haemoglobin, total RBC, total WBC, ESR and RF values were assessed before initiation of the treatment and after for 28 days of the treatment. The results showed significant incline or decline in each parameter in the study period of 28 days. While their changes were rectified with the oral administration of methanolic extract of the plant at a dose of 250mg/kg. The methanolic extract boosted the levels of Hb, RBC and simultaneously reduced WBC, ESR levels along with the serological factor RF. The plant extract showed effective results in the haematological parameters, when compared to the standard reference drug Dexamethasone. The results from the study suggest that the plant has potential effect in curing arthritis.
Comparison of Flutter and Autogenic Drainage on Airway Clearance In Patients with Moderate Chronic Bronchitis.
Authors: Dr. Chandrakant B Patil  , Dr. Javid H Sagar  
Published: October 2020

Patients with COPD have large amount of secretions. Many conventional and advanced techniques are used to clear the respiratory secretions. Flutter device is a hand held device which works on principle of positive expiratory pressure to improve patient’s ability to eliminate excessive secretions. Autogenic drainage is a self-drainage technique used for controlled breathing and moving excessive secretions. There is paucity of literature about this newer techniques used for chest clearance in moderate chronic bronchitis, so the present study is conducted with aim to find the effect of autogenic drainage and flutter device for airway clearance in individuals with moderate chronic bronchitis. A Comparative study was conducted on 30 subjects selected as per inclusion and exclusion criteria and divided into 2 groups by convenient sampling method. Group A was treated with flutter device and Group B by autogenic drainage technique. The treatment duration was 30 minutes per session, 2 sessions per day, 5 days/week for 1 week. The outcome measures used was oxygen saturation, peak expiratory flow rate and rate of perceived exertion on Borg scale. At the end of 1 week, both groups showed improvement in pre post values within group but between group comparison we found statistically significant improvement in group A (Flutter device) than Group B (autogenic drainage). The SpO2 value showed appreciable significant improvement in group A than group B (p=0.0066). The rate of perceived exertion showed extremely significant improvement in group A than group B (p<0.0001). The peak expiratory flow rate showed statistically significant improvement in group A than group B (p=0.0004).The study concluded that though both the techniques is better for airway clearance in chronic bronchitis but flutter device is more effective than autogenic drainage.
In Silico Approaches to Study the Anti Cancer Potential of Bioactive Compounds of Apium leptophyllum Pers by Molecular Docking
Authors: M.Siva Ganesh  , Dr. J.Radhika  
Published: October 2020

The Indian traditional health care system has suggested the presence of bioactive compounds in herbs used for the treatment of cancer. Natural medicinal plants have been used as therapeutics since the Vedic era. In-Silico studies have demonstrated to be an important tool that facilitates the use of the structural diversity of the natural products and designing new drugs for various diseases. Isolation studies by GC-MS analysis revealed that the ethanolic seed extract of Apium leptophyllum Pers contain natural bioactive compounds such as Thymol, Alpha –Terpineol and 9,12- Octadecadienoyl chloride(Z-Z-). These three active compounds are found in higher concentration in the ethanolic extract of Apium leptophyllum Pers seeds. The isolated active compounds were subjected to docking studies using Glide module (Schrodinger). Research was performed to find out the potential molecular targets for these selected compounds. The effectiveness of In-silico approach was carried out by performing docking of known specific phenolic mono terpenoids such as Thymol inhibitors against their respective selected macromolecules of cancer cell receptor. The present study was carried out to identify potential inhibitors for Bruton’s tyrosine kinase and checkpoint kinase 2. The docking studies revealed that the some essential active compounds such as Thymol, Alpha -Terpineol, and 9, 12- Octadecadienoyl chloride(Z-Z-) isolated by GC-MS analysis have potent anticancer activity against cancer cell. The study will further pave the way in designing other potent drugs and drug analogs. The novel molecular entities have the potential as leads which certainly aid in designing anti-cancer molecules in short span of time.
Screening and Characterization of Biofilm Forming Food Pathogens and their Biocontrol
Authors: M Flory Shobana  , Roshna Wilson  , M P Ayyappa Das  , V Subha Priya  , K Vivekanandhan  , V Manon Mani  
Published: October 2020

Microorganisms grow as a complex aggregation on a solid substrate to form a biofilm. This film serves as a defensive tool for various pathogenic microorganisms at different stress conditions. A well developed biofilm forms a complex diverse structure of dormant and active bacterial colonies with their enzymes and its excretory products. The main features of biofilm forming bacteria are their ability for surface attachment, high population density and extracellular polymeric substances. Biofilm has positive effects on biotechnology but it is extremely harmful in industry and medicine. Numerous chronic infections are caused by bacterial biofilm. Besides, biofilm also causes various infections of biomaterial used in medicine such as intravascular urethral catheters, orthopedic devices, contact lenses, heart valves and vocal cord prosthesis. Biomaterials used in medicine such as intravascular urethral catheters, orthopedic devices, contact lenses, heart valves and vocal cord prosthesis also gets infected by biofilm. The proposed work was carried out to study the biofilm-forming ability of bacteria from different food items. These bacteria were isolated and tested for biofilm-forming ability using Congo red and microtiter plate assay. All strong biofilm producers were tested for antibiotic sensitivity. Enzyme profiling and molecular characterization were done. Morphological and biochemical characterization of isolates was also carried out.
Aktivitas Antidiabetes Ekstrak Air-Etanol, n-Heksan, dan Etil Asetat Uwi Banggai (Dioscorea alata L.) Dengan Metode Induksi Aloksan Pada Mencit Jantan (Mus musculus)
Authors: Khaerati Khildah , Amini Delina , Ihwan  
Published: October 2020

Hyperglycemia is a condition of increased blood glucose levels caused by insufficient insulin enzymes produced to control blood sugar levels in the body. This study aimed to determine the activity of ethanol-water, nhexane, and ethyl acetate extracts of Dioscorea alata L. in reducing blood glucose levels in hyperglycemia modeled mice that were given intraperitoneal alloxan induction. 25 white rats were divided into 5 groups of test animals. Each group consists of 5 mice. The first group was given 0.5% sodium carboxymethylcellulose solution as a placebo, the second group was given 0.65 mg/kg BW glibenclamide as a positive comparison group, the third group was given the suspension of ethanol-water extract, the fourth group was given n-hexane extract, and the fifth group was given ethyl acetate extract at a dose of 140 mg/kg BW. The test preparation was orally given within 14 days of testing. The test was measured as the initial blood glucose levels of mice after alloxan induction and after giving the test preparation suspension. The results of the qualitative analysis illustrate that the water-ethanol extract can reduce blood glucose levels by 31.39%, n-hexane extract by 51.11%, and ethyl acetate extract by 50.77%. The results of quantitative analysis using One Way ANOVA method showed that the water-ethanol, n-hexane, and ethyl acetate extracts significantly decreased the blood glucose levels of mice. The best antidiabetic activity was ethyl acetate extract with a decrease in rat blood glucose levels by 169 mg/kg BW.
PENGARUH PEMBERIAN RASIO RUMPUT ODOT (Pennisetum purpureum cv. Matt) DAN KALIANDRA (Calliandra calothyrsus) PADA SAAT KEMARAU TERHADAP TINGKAT STRES DOMBA DI BPPTDK MARGAWATI GARUT
Authors: Nazhari Salsabilla 
Published: October 2020

Penelitian bertujuan untuk mengetahui pengaruh pemberian rasio rumput Odot (Pennisetum purpureum cv. Mott) dan Kaliandra (Calliandra calothyrsus) pada saat kemarau terhadap tingkat stres Domba Garut. Penelitian ini dilaksanakan di BPPTDK Margawati Garut dan Analisis darah di Multitest Lab, Bandung pada tanggal 2 Januari 2020 sampai 16 Januari 2020. yang Objek dalam penelitian ini adalah 25 ekor Domba Garut dengan bobot badan 20-40 kg yang diambil secara acak. Metode yang digunakan dalam penelitian ini ialah eksperimental dengan Rancangan Acak Lengkap (RAL) dengan lima perlakuan yang diulang sebanyak lima kali. Perlakuan berupa P0= Tanpa perlakuan, P1= 100% Rumput Gajah, P2= 75% Rumput Gajah + 25% Calliandra calothyrsus, P3= 50% Rumput Gajah + 50% Calliandra calothyrsus, dan P4= 25% Rumput Gajah + 75% Calliandra calothyrsus. Data analisis dengan uji sidik ragam. Hasil penelitian menunjukkan bahwa pemberian rasio Rrumput Oodot dan Kka liandra berpengaruh tidak nyata (P> 0,05) jumlah neutrofil, jumlah limfosit, maupun rasio neutrophil dan limfosit pada Domba Garut, namun ternyata domba-domba di BPPTDK Margawati Garut mengalami rendahnya jumlah neutrofil (neutropenia).