bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Biological Applications of Naphthalimide Benzothiazole As DNA-Targeted Anticancer Agents
Authors: Li Xiaolian , Chen Xuehui 
Published: February 2020

Cancer is a major extensive health problem which is the second leading cause of mortality in developed countries and most frightening disease in humans. DNA, as the carriers of genetic information of the living body, is not only the basis of biological growth, development, reproduction and other important life activities, but also closely related with tumor, viral infection and genetic diseases. The DNA is becoming one of the most promising biological targets of developing antitumor agents to constrain tumor cell growth.
The structure of precursor 1,8-naphthalimide was used as parent compound, and the triazole pharmacophore and benzothiazole was linked to naphthalene at 4 site by Click reaction. Based on this, we synthesized a series of novel “non-fused” naphthalimide derivatives first. Their structures were proved by TOF MS and 1HNMR. Then we used UV-vis spectra, Fluorescence spectra, CD spectra and viscosity assay to discuss their action modes on DNA. Finally we employed MTT assay to further evaluate their antitumor activities.
The UV-vis spectra, fluorescence spectra, CD spectra and viscosity assay showed that the compounds could intercalate into DNA. The changes of UV-Vis spectra and enhancement of fluorescence intensity proved that the compounds could intercalate into the DNA effectively. CD spectra results indicated that M3 could turn the conformation of DNA from B to A-like, M4 could change the B-DNA to C-DNA, and M5, M6 stabilized the B-DNA. According to the bioactivities assays, the compounds exhibited efficient toxicity against tumor cells in vitro, in particular M3 and M4, whose IC50 values against MCF-7 cells and Hela cells were 0.35μM, 0.12 μM and 0.66 μM, 0.19 μM, respectively. Moreover, both of them had better selectivity against MCF-7 cells and Hela cells than 7721 cells. When two nitrogen atoms of the side chain of the compounds separated by two carbon atoms, it showed significant inhibitory activity, such as M1, whose IC50 values against MCF-7 cells, Hela cells and 7721 cells were 2.33 μM, 0.35 μM and 0.49 μM, respectively.Fig. 1 CD spectra of naphthalimide derivatives
Introducing various flexible side chains amine has great impact on biological activities of naphthalimide derivatives. It has vast importance to expand and develop new and efficient antitumor drugs of naphthalimide. It’s an effective way to improve the efficacy of antitumor activity by introducing the structure of triazole and benzothiazole to naphthalimide in the para position.

Acknowledgements

We are grateful to the National Natural Science Foundation of China (21576043), supported by “the Fundamental Research Funds for the Central Universities”.

Figure 1
(Invited) Imperceptible Graphene Based Electronic Tattoo Sensors
Authors: Kabiri Ameri Shideh , Lu Nanshu , Akinwande Deji 
Published: February 2020

During last decade, there have been advances in wearables with applications in mobile healthcare, athletic, assistive technology, human machine interface and internet of things. However, current wearable sensors and systems have at least one or more of the following drawbacks: they are bulky, expensive, distractive, unsuitable for long term measurement or prone to motion artifact.
We present ultrathin graphene based electronic tattoo (GET) sensors with the overall thickness of less than 500 nm. Presented e-tattoo sensors can be laminated on skin like as temporary tattoo and form conformal contact to microscopic texture of the skin. GET is a set of dry sensors with electrode-skin interface impedance comparable to wet gel electrodes that are gold standard in medical applications. Low electrode-skin interface impedance of these e-tattoo sensors results in high signal to noise ratio and high sensing quality. Due to low areal mass density of GET, it attaches to skin without any adhesive or tape, just by Van der Waals force. Presented e-tattoos are both optically and mechanically imperceptible, therefore, they are desirable for applications in prominent areas of appearance such as face. We present the successful demonstration of GET applications for electrocardiography (EEG), electroencephalography (EEG), electromyography (EMG), electrooculography (EOG), skin temperature sensing, skin hydration sensing and human robot interface.
Experimental Study on Calendaristic Degradation and Self-Discharge of 3.4 Ah Lithium-Sulfur Pouch Cells
Authors: Knap Vaclav , Stroe Daniel Ioan 
Published: February 2020

Lithium-Sulfur (Li-S) batteries represent one of possible development pathways of Lithium based batteries, which are expected to provide benefits of high volumetric energy density, various safety features and low production cost 1. Already nowadays, one can find demonstrated applications, which heavily depend on unique attributes of Li-S batteries, e.g. high-altitude long-endurance unmanned aerial vehicles capable to endure for an extended periods of time in air (currently proofed for 14 day without landing) 2. However, wide commercialization of Li-S batteries is still hindered mainly by their limited performance and short lifetime 3.
Both, cycling and storage, influence the Li-S battery lifetime. The degradation is often assigned to the irreversible relocation of polysulfides, which results into the corrosion of lithium metal anode, degradation of sulfur cathode and surface passivation of both electrodes 4. These degradation aspects were studied and discussed in literature into a certain degree; however, as pointed out in Ref. 3, some observations are possible to be done only at commercial-size cells, instead at coin cells, which determines the further focus of this work on a larger format cells, specifically pouch cells. The Li-S pouch cells were previously studied for an effect of cycling degradation on sulfur cathodes 5 and lithium metal anodes 6. The current study brings an experimental investigation of a capacity fade and a self-discharge with a periodic one month checking for storage of Li-S cells at various conditions of state-of-charge and temperature. The methodology presented in Ref. 7 is used for evaluation of the battery performance during the degradation in terms of capacity, resistance, power capability and shuttle current.

M. Wild, L. O’Neill, T. Zhang, R. Purkayastha, G. Minton, M. Marinescu, and G. J. Offer, Energy Environ. Sci., 8, 3477–3494 (2015).

http://defence.airbus.com/portfolio/uav/zephyr/, accessed at 20th November 2017.

T. Cleaver, P. Kovacik, M. Marinescu, T. Zhang, and G. Offer, J. Electrochem. Soc., 165, A6029–A6033 (2018).

S.-H. Chung and A. Manthiram, ACS Energy Lett., 1056–1061 (2017).

S.-E. Cheon, S.-S. Choi, J.-S. Han, Y.-S. Choi, B.-H. Jung, and H. S. Lim, J. Electrochem. Soc., 151, A2067 (2004).

X. B. Cheng, C. Yan, J. Q. Huang, P. Li, L. Zhu, L. Zhao, Y. Zhang, W. Zhu, S. T. Yang, and Q. Zhang, Energy Storage Mater., 6, 18–25 (2017).

V. Knap, D. I. Stroe, R. Purkayastha, S. Walus, D. J. Auger, A. Fotouhi, and K. Propp, ECS Trans., 77, 479–490 (2017).

Figure 1
Cathode Nanostructuring and Separator Modification for High-Performance Lithium-Sulfur Batteries
Authors: Yu Xiaoyun , Zhou Guangmin , Cui Yi 
Published: February 2020

Battery technologies involving Li-S chemistry are promising approaches to realize inexpensive and high energy density storage for sustainable energy applications. However, current Li-S batteries still suffer from short life-time due to active material loss through the soluble polysulfide molecules shuttling between battery cathode and anode.[1] We present herein our recent advances in the understanding of the electrochemical reactions at Li-S battery cathode and addressing the shuttle effect by polysulfide trapping. Specifically, an in-operando characterization technique based on optical microscopy is developed to intuitively visualize the selective deposition of sulfur and Li2S in battery cathodes, and the critical roles of current collectors and additives, including different metals and semiconductors, are demonstrated. Accordingly, innovative cathode architectures are designed to control the oriented deposition and diffusion of sulfur-containing species. In particular, an ultrathin and compact blocking layer of 2D MoS2 and WS2 nanoflakes, with a thickness of ca. 15 nm, are deposited on separator through a solution based self-assembly method,[2] which effectively adsorb polysulfide molecules and thus suppress their diffusion to the battery anode. In addition, Li2S-metal composites and polymer-metal hybrid networks are fabricated as hosts for sulfur cathodes to enable rapid battery charge-discharge processes given the large active surface area and better control of charge (or discharge) product deposition.[3] Combining these two strategies, we report greatly enhanced specific capacity (over 1200 mAh g-1) and cyclability (over 500 cycles) for the nanostructured sulfur cathodes compared to the conventional carbon-sulfur based cathode, and the routes to further improving high-energy and long-life Li-S battery are discussed.
[1] Seh, Z. W.; Sun, Y.; Zhang, Q.; Cui, Y. Chem. Soc. Rev. 2016, 45, 5605.
[2] Yu, X.; Prévot, M. S.; Guijarro, N.; Sivula, K. Nat. Commun. 2015, 6, 7596.
[3] Zhou, G. M.; Sun, J.; Jin, Y.; Chen, W.; Zu, C. X.; Zhang, R. F.; Qiu, Y. C.; Zhao, J.; Zhuo, D.; Liu, Y. Y.; Tao, X. Y.; Liu, W.; Yan, K.; Lee, H. R.; Cui, Y. Adv.
Mater. 2017, 29, 1603366
Orthotellurate Cathode Frameworks for Potassium-Ion Battery
Authors: Masese Titus , Yoshii Kazuki , Okumura Toyoki , Senoh Hiroshi , Shikano Masahiro 
Published: February 2020

As a low-cost alternative to lithium, potassium-ion battery (PIB) has recently attracted great attention. PIB can be a high-voltage contender considering the significantly negative potential of the K+/K redox couple, which is close to or even lower than Li depending on the solvent [1,2]. Nonetheless, the large ionic radius of potassium coupled with significant strain accompanying potassium (de)insertion, the number of potassium-based compounds (particularly, cathode materials) that can practically be utilized is limited.
Exploration of the broad class of orthotellurate frameworks based on K6TeO6 has led us to identify new cathode frameworks that can reversibly (de) insert potassium ions, not only at high voltage but also at decent capacities. Figure 1 shows a layered crystal structure of K2Ni2TeO6, a new cathode material synthesized via the conventional solid state method. The structure entails a honeycomb-like network of NiO6 octahedra (in purple) surrounding each TeO6 octahedon (in blue). Potassium atoms (in brown) occupy trigonal prismatic sites sharing faces with NiO6 or TeO6 octahedra.
During the meeting, we will highlight the synthesis, crystal structure and electrochemical performance of K2Ni2TeO6 as a new cathode material for PIB [3].

Reference
s
:

[1] Y. Marcus, Pure Appl. Chem., 57 (1985) 1129-1132.
[2] S. Komaba, T. Hasegawa, M. Dahbi and K. Kubota, J
.
Power Sources,
60 (2015) 172-175.
[3] T. Masese, K. Yoshii, T. Okumura, H. Senoh, M. Shikano, manuscript submitted.

Figure 1. Schematic presentation of K2Ni2TeO6 viewed along [110] direction. NiO6

tetrahedra (blue), TeO6 octahedra (purple), and K atoms (brown) are illustrated.

Figure 1
Preparation of Disordered Carbon Anode By Mechanical Method for Sodium Ion Battery
Authors: Lee Su Chan , Chung Kyung Yoon , Jun Seong Chan 
Published: February 2020

The application of energy storage device is sharply expanding its application area from small portable mobile devices to large-scale energy storage systems (ESS). The cost of energy storage device has become more important as the demand of large-scale device expands. The outstanding performance such as large energy density of lithium ion battery (LIB) makes itself a most powerful energy storage device. However, LIB has some growing concerns about cost due to its limited reserves of raw materials. For large-scale ESS, alternative energy storage system other than LIB with low price and moderate performance is required. There have been extensive studies on various types of energy storage devices meet these demands, and sodium ion battery (SIB) is one of the most promising candidate. Sodium ion, which is an alkaline metal, has similar characteristics with lithium ion even though it is earth abundant metal. Researchers have started the sodium ion battery study by focusing on these similarities and the main purpose of this study is to develop the post-LIB with low cost. The main difference between sodium and lithium ion is potential difference ((E0
Na/Na+=-2.71 V and E0
Li/Li+=-3.04 V) and ionic radius. Many materials have been studied for SIB electrode, but only a few materials achieve a certain level of performance even though those candidate materials show good lithium ion storage performance. The ionic radius difference between sodium and lithium ion is thought to be main cause of this phenomena. Especially in case of anode, the graphite was most powerful LIB anode material with low price and good performance but graphite has very low capacity with sodium ion. So there are many efforts to develop SIB anode to achieve similar performance level graphite of LIB. The main advantage of SIB is a low cost, therefore the research of SIB anode should be conducted with considering the price efficiency. To meet this point, the anode of SIB should be developed with carbon material, which has low price of raw material.
In this presentation, the fabrication of disordered carbon with mechanical method for SIB anode will be reported. The facile and cost-effective mechanical milling process can make high quality disordered carbon and it has good sodium ion storage performance. The sodium ion storage mechanism of mechanically milled disordered carbon also will be presented. The details will be discussed at the meeting.
Na-Ion Full Cell: Electrochemical Study Using Prussian Blue Cathode and Tin Sulphide (SnS) Anode with Additive-Free Ether-Based Electrolyte System
Authors: Dutta Prasit Kumar , Mitra Sagar 
Published: February 2020

Nowadays sodium-ion battery technology is becoming more popular among researcher as it has been considered as an alternative to lithium-ion batteries. As an alternative to the state-of-the-art lithium-ion battery technology, sodium-based research needs to come out with an easily adaptable option satisfying adequate energy density which can cover the dearth of the demand for lithium-ion batteries in near future. However, the current sodium technology is still lacking to reach enough energy requirement at the cheaper price point. Recent research trend has arrogated hard carbon anode as conventional graphite is still not an adequate performer for sodium. In addition, NVP has been chosen as one of the best options as cathode due to having higher energy density. Combining NVP and hard carbon, carbonate-based electrolyte with an additive (FEC) is conjunct to build a sodium-ion full cell.1 However, the overall cost of producing this system is still high compared to lithium technology.2 Hence, achieving an adequate energy density at low-cost is an open challenge for the current generation researchers.
In this work, we merge two systems: an alloy-based anode and high rate capable cathode in conjunction with an additive-free electrolyte. For the first time, a Na-ion full cell is fabricated combining SnS anode,3 Prussian blue (PB) cathode and NaClO4-TEGDME electrolyte.4 The electrodes were used without any carbonaceous coating. In addition, both the electrode materials were prepared using a rapid bulk synthesis pathway which benefits the time of material preparation, hence can easily be applied in large-scale production. The cathode works nearly 3 V vs. metallic sodium while the anode works mostly below 1.2 V (Fig. 1a). Hence, the overall combination produces an average of 1.8 V full cell (Fig. 1d). Capacity coming from the full cell is nearly 80 mAh g-1
PB (Fig 1c) which corresponds to 135 Wh Kg-1 for the gravimetric energy density. Fig. 1b demonstrates that a single coin cell is capable of powering a LED lamp.

Figure 1
Operando X-Ray Diffraction and EIS on NCA Battery Cathodes
Authors: Passarello Donata , Takacs Christopher J , Steinrueck Hans-Georg , Toney Michael F 
Published: February 2020

In recent decades, lithium-ion batteries (LIB) have revolutionized the portable electronics industry and the emerging market of electric vehicles (EVs) and hybrid electric vehicles (HEVs). Significant efforts have been devoted to fundamental and commercial research and development of layered oxide cathodes with small structural deformation upon lithium intercalation and de-intercalation. Towards this end, there is a need to couple modern electroanalytical techniques with advanced structural characterization methods.
Here I discuss current progress to complement electrochemical impedance spectroscopy (EIS) with in operando x-ray methods, focusing on correlating time-dependent measurements in order to add structural information to the electrochemical models. EIS is widely used as a measure of kinetics and interface properties in a wide variety of systems. In a battery system, correlating the impedance parameters to the cycling efficiency of the cell, helps predicting the likelihood of battery failures. While EIS is a very powerful analysis tool, the interpretation of the data is non-trivial, as they can`t be fit by a unique model. In this study, we investigate the structural behavior of LiNi0.80Co0.15Al0.05O2 (NCA) cathode material, of particular interest as it exhibits high structural stability. We aim to gain additional structural information from x-ray diffraction methods in order to unambiguity model the EIS data.
Expanded Biomass-Derived Hard Carbon with Ultra-Stable Performance for Sodium-Ion Batteries
Authors: Zhang Yingjie , Zhu Ziyi , Li Xue , Dong Peng 
Published: February 2020

As a new generation of high performance integrated energy storage battery system, the key factor in the development and application of sodium-ion batteries (SIBs) are the high-performance electrode materials. As a kind of hard carbon, the biomass-derived carbon has attracted much attention from experts and scholars due to the characteristics of rich-resource, low-cost and simple preparation process. It also can maintain the natural properties of biomass precursors, which contribute to the improvement of electrochemical performance. In the present work, cherry petals were used as precursors to prepare a hard carbon (CP) by a facile preparation. When it was used as an anode material for SIBs, CP exhibits high storage capacity with a high initial reversible capacity (310.2 mAh g-1), outstanding cyclic stability (the capacity retention rate was 99.3% after 100 cycles at 20 mA g-1) (Figure 1), favorable rate capability (146.5 mAh g-1, even at a very high current density of 500 mA g-1) and a high initial coulomb efficiency of 67.3%. In particular, approximate 45% of the capacity from CP is contributed by sodiation below 0.1 V (vs. Na+/Na). This low potential plateau makes CP energetically favorable as an anode material. The excellent electrochemical properties of CP can be attributed to its "open" lamellar structure-associated the nanoscale mesoporous, the presence of nitrogen/oxygen functional groups on the surface, and expanded interlayer distance (~0.44 nm) (Figure 2).

Figure captions

Figure 1. Cycling performance of CP (at 20 mA g-1).
Figure 2. (a) HRTEM and SAED images of CP; (b) Contrast profiles along the arrows indicate interlayer distance of CP.

References

[1] Qiu S, Xiao L, Sushko M L, Han K S, Shao Y, Yan M, et al. Manipulating adsorption-insertion mechanisms in nanostructured carbon materials for high-efficiency sodium ion storage. Adv. Energy Mater. 2017; 7: 1700403.
[2] Liu, P, Li, Y, Hu, Y. S, Li, H, Chen, L, Huang, X. A waste biomass derived hard carbon as a high-performance anode material for sodium-ion batteries. Journal of Materials Chemistry A 2016; 4: 13046-13052.

Figure 1
Lithiation Effect of the Poly(Acrylic Acid) Binders on the Silicon Anode of Lithium-Ion Batteries
Authors: Hu Bin , Jiang Sisi , Zhang Jingjing , Zhang Zhengcheng , Zhang Lu 
Published: February 2020

The exploration for the next generation of anode materials in the lithium-ion batteries is a vital subject in the past few years due to the huge demand of high capacity batteries. Silicon (Si) stands out as a promising anode material due to its high theoretical specific capacity (4200 mAh/g), enviroment friendliness and low costs. However, Si nanoparticles (NPs) experience severe volume changes up to 300 % during the lithiation/delithiation process, which leads to dramatic particle degradation and thus capacity loss. Novel polymeric binders with enhanced mechanical properties have been identified as one effective approach to alleviate this issue, and some examples include carboxymethyl cellulose (CMC), alginate, and poly(acrylic acid) (PAA), etc. By using those binders, cell performance has been greatly improved as compared to the conventional polyvinylidene fluoride (PVDF) binder. Among those candidates, PAA outperforms others possibly due to its superior mechanical properties. In this report we have attempted to investigate the lithiation effect of the PAA binders. Lithiating PAA binders could benefit the electrode laminate processing as well as cycling performance. A commercially available PAA sample with a characterized Mn of 147 kDa was used in this study. By titrating with LiOH solution, we controlled the pH of 10 wt% PAA solutions as well as the lithiation ratio (Table 1). Those binder solutions were used to fabricate silicon/ graphite composite electrodes that composed of 10 % PAA, 73 % Hitachi MagE, 15 % Si NPs (NanoAmour, 70-130 nm), and 2 % Timcal C45. Half-cell cycling results (Figure 1) indicated that different lithiation of PAA binders has dramatic impact on their corresponding cycling performance. Lower lithiation tends to afford higher initial specific capacities and better capacity retentions. Actually, the best performer is PAA binder with no lithiation at all. This result is a little contradicting to previous study but we reason that our lithiation agent, LiOH, may have side reasons with silicon particles, as evidenced by the dramatic decrease of the silicon capacity. Full cell cycling as well as further characterization of electrode surface is ongoing.
Table 1. The calculated mol% of LiOH (to AA monomer) and the resulting pH values of the final PAA solutions.

LiOH %
0
25
50
75
85
90
91
92.5
95
100

pH
2.08
4.22
4.84
5.49
5.97
6.97
10.03
11.96
12.28
12.59

Figure 1. Specific discharge capacity and Coulombic efficiency of PAA binders with different pH values.

Figure 1