bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faith-Based Lifestyle Intervention Program Reduces Metabolic Syndrome in a High-risk Population
Authors: Davis Ronda Rose , Hwang Hyo-Jeong , Reid Easton A. , Chung Joo Youn , Scott Andrea Leah , Powell-Stoddart Helen , Jung Tae-Hwan , Han Kyoung-Sik 
Published: July 2020

Abstract
Introduction: The aim of this study was to investigate the effects of a two-week lifestyle intervention on risk factors contributing to metabolic syndrome that incorporated a natural environment with spiritual motivation, plant-based nutrition, personalized physical activity, and health education.Methods: The demographic population included forty-two middle-aged and aged participants of African-American or Afro-Caribbean/Other Afro-descent, considered “high-risk” according to clinical cardiometabolic risk indicators.Results: Based on the stratified analysis, 59.5% and 40.5% were of African-American and Afro-Caribbean/Other Afro-descent respectively, with a mean age of 59.23 ± 11.24 years. The paired t-test indicated that plasma concentrations of glucose (P = 0.043) and triglyceride (P = 0.002) post-intervention reduced compared to pre-intervention baselines. In female participants, blood HDL cholesterol concentrations significantly (P < 0.0001) increased compared to pre-intervention values.Conclusion: This research suggests that the Fit 4 You Retreat lifestyle intervention program significantly reduced cardiometabolic vulnerability in this high-risk middle-aged and aged population.
Psychometric properties of Nurses Professional Values Scale-Revised: An Iranian version
Authors: Hosseini Fahimeh Alsadat , zarshenas ladan , Parvan Kobra , Bagherian Samaneh , Thomson Brian 
Published: July 2020

Abstract
Background

Professional values are the basis of development of professional identity and commitment. Evaluation of professional values provides critical information regarding effective strategies for their integration in professional performance and clinical learning. The present study aimed to determine the psychometric properties of Nurses Professional Values Scale-Revised (NPVS-R) in Iranian population.
Methods

This methodological study was conducted on 439 students in the last semester of nursing selected from Iran’s universities using stratified single-stage cluster sampling. After back translation, its face, content, and construct validity were assessed. Its reliability was also evaluated by determining Cronbach’s alpha using internal consistency method. All analyses were performed using the SPSS statistical software, version 19.
Results

Considering face validity, all items’ impact scores were above 1.5. Regarding content validity, CVR and CVI of all components were > 0.6 and = 1, respectively. After exploratory factor analysis, the number of items was reduced to 25 and five factors explained 52.26% of the total variance. Moreover, the reliability coefficient was 0.53–0.83 for the factors and 0.91 for the whole scale.
Conclusions

The Persian version of NPVS-R had acceptable validity and reliability in Iranian context. Yet, further studies have to be conducted on this instrument with different cultural backgrounds.
Association of NT-proBNP and Subsequent Major Adverse Cardiovascular and Cerebral Events in Patients with Successful PCI for ACS and Normal LVEF
Authors: Wang Jia-Li , Zhao Shu-Mei , Chen Hui , Guo Chun-Yan , Zhao Xue-Qiao , Li Hong-Wei 
Published: July 2020

Abstract
Background: Does N-Terminal pro-brain natriuretic peptide (NT-proBNP) predict subsequent major adverse cardiovascular and cerebral event (MACCE) in patients received successful percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and had normal left ventricular ejection fraction (LVEF)? Methods: 3986 ACS patients were divided into 4 groups based on the quartile (Q) values of peak NT-proBNP measured during hospitalization. All patients were followed for MACCE, a composite of all-cause death, non-fatal myocardial infarction (MI) or stroke, and heart failure requiring hospitalization (HFRH), during a median of 35 months. The incidence of MACCE was compared among Q1-Q4. Receiver operation characteristic curves (ROC) were generated to compare the area under the curve (AUC) for MACCE, cardiovascular (CV) death and HFRH by adding NT-proBNP to the TIMI (thrombolysis in myocardial infarction) risk score.Results: The incidences of MACCE (5.6%, 9.1%, 13.0%, 20.1%, P <0.001), all-cause death (1.0%, 2.5%, 4.1%, 8.4%, P <0.001), non-fatal MI (2.0%,3.4%,4.8%,6.2%, P <0.001) and HFRH (1.5%, 2.3%, 4.1%, 5.9%, P <0.001) were significantly increased from Q1 to Q4, but, not stroke (1.4%, 1.4%, 1.3%, 2.1%, P =0.438). Each median level (337pg/ml) increase in NT-proBNP was significantly and independently associated with increased risk of MACCE (HR 1.02, 95%CI, 1.01-1.03; P <0.001). Compared with TIMI (thrombolysis in myocardial infarction) risk score alone, TIMI+NT-proBNP showed improved AUCs: CV death (0.76 vs. 0.72, P =0.0008), and HFRH (0.68 vs. 0.66, P =0.0017), MACCE (0.70 vs. 0.69, P =0.0012), respectively. Conclusion: NT-proBNP was significantly and independently associated with increased risk of subsequent MACCE in 3 years in ACS patients who received successful PCI and had normal LVEF, and improved the prognosis of major adverse events in addition to the TIMI risk score.
Tumor-To-tumor Metastasis: Prostatic Cancer Metastasizing to Malignant Solitary Fibrous Tumor of The Lung
Authors: Lian Yuane , Yang Yinghong , Feng Changyin , Kang Deyong 
Published: July 2020

Abstract
Background: Tumor-to-tumor metastasis is an extremely rare but interesting phenomenon. Prostatic cancer metastasizing to malignant solitary fibrous tumor (SFT) of the lung has not been previously reported.Case Presentation: In this report, we describe the case of a 60-year-old man presenting a large solitary neoplasm in the left lung on computed tomography. Pathology after left lung wedge resection indicated two different cancerous cell components: SFT cells with malignant potential and prostatic cancer cells. The heterogeneous cells of prostatic origin were confirmed by using evidence from fine needle aspiration and pathology after radical prostatectomy.Conclusions: We report the first tumor-to-tumor metastasis of prostatic cancer to lung malignant SFT.
Comprehensive Analysis of Differentially Expressed Long Non-Coding RNA-mRNA in The Adenoma–Carcinoma Sequence of DNA Mismatch Repair Proficient Colon Cancer
Authors: Li Wenkun , Li Qian , Ge Jiang , Wang Yun , Li Nanshan , Lao Yueqiong , Wang Yadan , Liu Kuiliang , Guo Chunmei , Lin Wu , Jiang Guojun , Wei Nan , Wang Canghai , Liu Hong , Wu Jing 
Published: July 2020

Abstract
Background DNA mismatch repair proficient colon cancer (pMMR CC) is the most common subtype of sporadic CC. However, the role of long non-coding RNAs (lncRNAs) in pMMR CC carcinogenesis has not been fully elucidated. Methods In the present study, we conducted transcriptomic analysis of lncRNAs-mRNAs in five low-grade intraepithelial neoplasia (LGIN), five high-grade intraepithelial neoplasia (HGIN), four pMMR CC, and five normal control (NC) tissues. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway, and Co-Expression Network analyses were performed to elucidate the functions of lncRNAs and mRNAs as well as their interactions. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate five dysregulated lncRNAs in a large set of colon tissues. Receiver-operating characteristic (ROC) curves were employed to evaluate the performance of the candidate lncRNAs. Results A set of 5783 differentially expressed lncRNAs and 4483 differentially expressed mRNAs were detected among the LGIN, HGIN, pMMR CC, and NC samples. These differentially expressed lncRNAs and mRNAs were assigned to 275 significant GO terms and 179 significant KEGG enriched pathways. qRT-PCR confirmed that the expression of five selected lncRNAs (ENST00000521815, ENST00000603052, ENST00000609220, NR_026543, and ENST00000545920) were consistent with the microarray data. ROC analysis showed that four lncRNAs (ENST00000521815, ENST00000603052, ENST00000609220, and NR_026543) had larger area under the ROC curve (AUC) values than serum carcinoembryonic antigens, thereby distinguishing NC from pMMR CC. Conclusions Several lncRNAs play various roles in the adenoma–carcinoma sequence and may serve as potential biomarkers for the early diagnosis of pMMR CC.
Visual Outcome, Microbiological Profile and Antibiotic Sensitivity of Infectious Keratitis in a Tertiary Referral Center
Authors: Stanfield Kristina Moore , Huang Bo , Matherne Blake , Adah Osasu , McClung Daniel , Le Thuy , Ladner Morgan 
Published: July 2020

Abstract
Purpose:Treatment of infectious keratitis is chosen by identification of infection source with associated antibiotic susceptibilities. Because culturing corneas may take days to weeks to result, the mainstay of treatment is empirical therapy with broad-spectrum antimicrobials that are started before culture results return. We aim to record the microbiological profiles with associated antibiotic susceptibility patterns isolated from corneal cultures in patients with infectious keratitis, as well as visual outcomes over a 5-year period.Methods:A retrospective analysis of medical records of patients who presented to UMMC from 1/1/2014 to 12/31/2018 with keratitis or corneal ulcer were included in this study based off diagnosis codes.Results:Of 563 corneal infections analyzed, 202 (35.9%) had positive cultures. The most frequently isolated organism was Coagulative negative Staphylococcus/Staphylococcus epidermidis, followed by Pseudomonas aeruginosa, and Staphylococcus aureus. Pseudomonas aeruginosa was isolated in 37.2% contact lens wearers. We found that 93.3% of gram-positive cultured bacteria were susceptible to vancomycin with no resistance, and 81.8% of gram-negative bacteria were highly susceptible to tobramycin with no resistance. Regardless of treatment, 19.8% of patients needed some type of additional procedure, with the most common procedures being corneal transplant & evisceration. Conclusion:CNS, Pseudomonas aeruginosa, and Staphylococcus aureus were the most common microbes causing infectious keratitis. Pseudomonas aeruginosa remains the most commonly identified organism in contact lens wears. The empirical treatment of vancomycin and tobramycin used at our institution remains an excellent treatment for these microbes.
The Serum Level of Vitamin D and Hypocalcemia in Thyroidectomy Candidate Patients Referred to a Tertiary Care Hospital in the North of Iran
Authors: Hemmati Hossein , Poursafar Mehdi , Farzin Mohaya , Motamed Behrang , Samidoost Pirooz , Rafiei Elahe , Bahush Soudabeh 
Published: July 2020

Abstract
Objective: Vitamin D plays a crucial role in calcium metabolism through the Parathyroid hormone (PTH) dependent process. The deficiency of this important nutrient may be associated with hypocalcemia after thyroidectomy. To evaluate the role of vitamin D in predicting hypocalcemia following total thyroidectomy.Results: sixty-two patients who underwent total thyroidectomy for benign or malignant thyroid disease were included in this prospective study. Preoperative vitamin D serum levels and PTH levels were determined. The results of our study showed In both groups with and without vitamin D deficiency, calcium levels decreased significantly (P = 0.01). In our study, it was found that there was no significant relationship between postoperative hypocalcemia and vitamin D deficiency. (P = 0.441). After reviewing the data and according to Spearman correlation statistical test, no significant relationship was observed between serum PTH and calcium after thyroidectomy (P = 0.340).Vitamin D deficiency is a risk factor of hypocalcemia after total thyroidectomy for benign goiter. Although post thyroidectomy hypocalcemia is multifactorial, vitamin D deficiency, particularly severe form, is significantly associated with the development of biochemical and clinical hypocalcemia vitamin D supplementation can prevent this unwanted complication in such patients.
Fluid Dynamics Simulation and Temperature Gradient Validation along a Greenhouse Temperature Gradient
Authors: Kim Sung Kyeom , Lee Hee Ju , Wi Seung Hwan , Lee Seong-Won , Seo ILHWAN 
Published: July 2020

Abstract
Background: Climate change is increasing the vulnerability of horticultural crop cultivation and production. It is urgent to study such extreme weather phenomena (heatwave, drought, etc.), and in particular, to evaluate crop productivity according to temperature change. For this purpose, the crop physiological response to temperature change in simulated weather conditions was studied. However, there is a limitation in artificial light wavelength, which requires experiments to be carried out in protected facilities or open fields. In this study, we simulated temperature differences with computational fluid dynamics (CFD) in tunnel-type greenhouses. They can create temperature gradients and improve the accuracy of CFD with vertically and horizontally measured temperature profiles. The growth and physiological response of Kimchi cabbage were examined and validated using a temperature gradient within a semi-closed plastic tunnel.Results: Correlation coefficients of measured heights were: 1.120, 0.597, and 0.459. Root mean square error was below 0.1025, which means the CFD simulation values were highly accurate. The error analysis showed that it was possible to accurately predict temperature gradients change within a semi-closed tunnel-type greenhouse using CFD techniques. CFD results showed an average error of 0.597°C compared to field monitoring results. The maximum temperature difference of GTG was 5.7°C, suggesting a well-controlled set point (6°C difference between outside conditions and inside conditions of GTG). In a cloudy day, the gradient temperature of GTG was well maintained by the set differential temperature (dT), which suggests that the set dT was not precisely and accurately performed in GTG of a sunny day. There was a significant difference in the growth, net photosynthetic rate, transpiration rate, and Ci concentration along with temperature differences in GTG. Conclusions: CFD can simulate temperature gradient distribution in a tunnel-type greenhouse and predict the temperature difference for equipment with different specifications. These facilities can be used in climate change-related studies, such as assessment of crop production area optimization, crop physiological response to temperature, vulnerability assessment of crop production under increasing temperatures, or extreme weather.
Improved Agrobacterium Tumefaciens-Mediated Transformation of Cucumber via Modified use of Antibiotics and Acetosyringone
Authors: Chai Li'ang , Du Changxia , Fan Huaifu , Liu Chen , Si Yuyang 
Published: July 2020

Abstract
Background: Cucumber (Cucumis sativus) is one of the most important vegetable crops in the world. As conventional breeding of cucumber is very challenging, genetic engineering is an alternative option to introduce important traits such as enhanced stress resistance and nutritional value. However, the efficiency of the transformation system depends on genotypes, transformation conditions, selection agents, etc. This study aims to speed up the process of Agrobacterium-mediated transformation of cucumber. ‘Xintaimici’, a very popular and typical north China-type cucumber variety, was transformed with Agrobacterium GV3101. The strain carried the pCAMBIA2300s plasmid, a double vector with the marker gene neomycin phosphotransferase II (npt II). Results: The research results indicated that cefotaxime sodium was suitable for inhibiting Agrobacterium in the screening and bud elongation stages. Timentin was best used during the rooting stage. Furthermore, 25 mg/L kanamycin was used in the early stage of screening and increased to 50 mg/L for further screening. At the bud elongation and rooting stages, 75 and 100 mg/L kanamycin was used, respectively, to improve the screening efficiency. To obtain the highest regeneration frequency of resistant buds, 50, 150, and 100 μM acetosyringone was added in the pre-culture medium, infection solution, and co-culture medium, respectively. To confirm the presence of the transgenes, DNA from npt II transgenic cucumber plants was analysed by polymerase chain reaction after transplanting resistant regenerated plants. Conclusions: We finally achieved an 8.1% conversion, which is among the highest values reported to date using the cucumber ‘Xintaimici’. Thus, an effective protocol for Agrobacterium tumefaciens-mediated genetic transformation of cucumber was optimized.
Determinants of Overall HIV/AIDS Knowledge Among Adolescent Girls and Young Women Aged 15–24 Years in Malawi
Authors: Mandiwa Chrispin , Namondwe Bernadetta , Munthali Mtondera 
Published: July 2020

Abstract
Background HIV epidemic remains a major public health issue in Malawi especially among adolescent girls and young women. Having accurate knowledge about HIV/AIDS is a key component of preventing the spread of HIV among adolescent girls and young women. Therefore, the aim of this study was to identify the determinants of overall HIV/AIDS knowledge among adolescent girls and young women in Malawi.Methods The study was based on cross-sectional data from the 2015-2016 Malawi Demographic and Health Survey. It involved 10132 adolescent girls and young women aged 15-24 years who reported to have ever heard of HIV/AIDS. The outcome variable was overall HIV/AIDS knowledge. Data were analysed by using descriptive statistics, cross-tabulation and multivariable logistic regression models. All the analyses were performed using complex sample analysis procedure of the Statistical Package for Social Sciences (SPSS version 22) to account for complex survey design.Results Of the total 10132 participants included in the study, 82.2% (n=8326) had high overall knowledge of HIV/AIDS. Around 25% of the participants did not know that using condoms consistently can reduce the risk of HIV and 23% of the participants believed that mosquitoes could transmit HIV. Several factors were significantly associated with women’s overall HIV/AIDS knowledge. Women who were aged 20–24 years (AOR=1.16; 95% CI=1.04–1.29), women from rich households (AOR = 1.22; 95% CI = 1.08–1.39),women who were working (AOR=1.29; 95% CI=1.16–1.44),women who were listening to radio at least once a week (AOR = 1.19; 95% CI = 1.05–1.35) and women who had secondary or higher education (AOR = 3.43; 95% CI = 2.67–4.42) were more likely to have high overall knowledge about HIV/AIDS compared to their counterparts.Conclusions The findings of this study suggest that some adolescent girls and young women in Malawi are lacking comprehensive HIV/AIDS knowledge. Lack of knowledge about HIV transmission and prevention methods among young women might pose a challenge to efforts to stop the spread of the HIV epidemic. To reduce the incidence of HIV, it is essential to design effective interventions that can increase HIV/AIDS knowledge among adolescent girls and young women in Malawi.
The Survival Rate and Its Predictors in HIV-Infected Patients of Kurdistan Province, Iran: A Retrospective Cohort Study
Authors: Darvishi Sonia , Rahmani Khaled , Seyfi Shirzad , Khazaei Salman , Homayonnezhad Sara , hamidi Omid 
Published: July 2020

Abstract
Objective: This study aimed to understand the prognostic factors that influence the progress and death in human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS) patients in developing countries. This study conducted in the Kurdistan Province, Iran from September 1988 to April 2020. Interest outcomes were time-estimated: (1) from HIV to AIDS and (2) from AIDS to death. The Cox proportional-hazard model also was used in order to consider the effects of different factors on survival rate.Results: A total number of 591 HIV-infected patients were assessed and the results showed that 1-year, 5-year, and 10-year probability of disease progression from HIV diagnosis to AIDS was 96%, 92%, and 88%, and that of death was 69%, 47%, and 27%, respectively. Cox’s multivariate analysis result's showed the following factors were significantly related to AIDS progression: the first CD4 count under 500, using ART, and history of drug use with hazard ratio of 1.93, 4.53, and 0.76, respectively. The mortality was significantly associated with unemployment, using ART with HR of 3.4, and 0.07, respectively. Unemployed AIDS-patients are also more likely to die; this, which need more attention in Iran.
Evaluating Treatment Patterns of Gastrointestinal Stromal Tumors in the Elderly and Predicting Outcomes by a Validated Model: A Population-based Study
Authors: Zhao Si , Zhu Hanlong , Zhang Xiuhua 
Published: July 2020

Abstract
Background: Data on the management and outcome of gastrointestinal stromal tumors (GISTs) in elderlypatients are scant due to their poor representation in clinical trials. Methods:In total, 1379 elderly patients (≥65 years) histologically confirmed GIST between2010 and 2016 were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database.Results: As a result,surgery alone was the predominant treatment used in both age groups. Patients aged ≥75 years who underwent surgery alone had a median survival of 69 months, chemotherapy alone 51 months, surgery plus chemotherapy 60 months, and no therapy 51 months. While among patients aged 65-74 years, the median OS was not reached (NR), 49, 83, and NR, separately. Besides, C-indexes for the OS nomogram in the training set and validation set were0.771 and 0.761, respectively. Of importance, the predictive model displayed a comparable result to the 8th American Joint Committee on Cancer TNM staging system (p＜0.05), demonstrating improved model discrimination. Conclusions: For elderly patients with GISTs, surgery alone or surgery plus chemotherapy seemed feasible and effective, conferring potential survival benefits even in very elderly patients. Moreover, this simple-to-use nomogram may assist clinicians in treatment decision-making and effectively predict 3- and 5-year survival.
Proposing a new strategy of combining machine learning with controlling cross-transmission of multi-drug resistant organisms of ICU
Authors: zou qian , Kaihong Fei , Mei Kang , Xianchen Li , Mengyuan Ding , Miaomiao Geng , Yanhong Zhu 
Published: July 2020

Abstract
Background

Multi-drug resistant organisms (MDROs) has become a global threat to public health. MDROs are normally transmitted from patients to patients via the hands of healthcare workers (HCWs). The key management of MDROs is control dissemination as sooner as possible.
Method:

We established a predictive rule based simply on experiences, and according to the result of this predictive rule we take a series of precautions of a general intensive care unit (ICU) from January 1, 2018, to December 31, 2019, only in one ward experimentally. In this study, we aim to assess the efficiency of the routine care practice which include pre-discrimination by the predictive rule and sequent precautions by doing difference comparisons.
Results

After comparing two wards in the hospital expenses and length of ICU stay, there are no statistical differences. Precautions contribute to the association between room number and status of MDROs infection/ colonization(p = 0.033), and infection/colonization rate of MDROs is different statistically between two wards(p = 0.006).
Conclusion

the routine care practice had controlled the cross-transmission of MDROs in some extent. Future, studies can engage in updating the predictive model based on big data and referred to experts’ experiences and adopt more efficient precautions for strengthening the transmission efficiency.