bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal energy capture by pyroelectric effect
Authors: Cárdenas F , Rodríguez J 
Published: June 2020

Abstract
Taking advantage of the physical nature of the pyroelectric materials, in this investigation a characteristic of these materials known as the pyroelectric effect was studied and corroborated, which allows this type of materials are sensitive to infrared electromagnetic radiation, and whose response can be seen in the form of electric potential difference. In this way, in this document the theoretical basis of operation of this effect is presented, and in turn, the results of experiments carried out in laboratories of the University of Santo Tomás Bogotá D.C. The experiments were performed using the “PIR325” sensor, which is composed of two thin films of pyroelectric material. In the first instance, the response of the sensor to thermal electromagnetic radiation produced by the human body is obtained, in the second instance, the same experiment is repeated, However, on this occasion, a Fresnel lens is used to ensure the highest infrared electromagnetic energy collection. Finally, the capture of the signals obtained in each experiment is performed and the results are contrasted, where the theoretical basis of the pyroelectric effect is demonstrated, and in turn, the importance of using a Fresnel lens in applications to carry out this type of sensors.
Technological surveillance as element for the positioning of public universities
Authors: Moya F O , Villero S L , Perez F P 
Published: June 2020

Abstract
This research work is primarily aimed at Technological Surveillance as an Element for the Positioning of Public Universities. This research is characterized by being descriptive, non-experimental design of transectional-descriptive type. The population was made up of the National Open and Distance University and the University of La Guajira, the units of informants made up of the managers responsible for the technologies in the mentioned universities. For the data collection, a simple questionnaire composed of 57 items and constituted by the response alternatives was always, almost always, sometimes, never and almost never. In turn, for the validation of the data collection instrument, it was necessary to submit it to 5 an expert and to apply a reliability test through the Alpha Cronbach statistics formula, giving a result of 0.83 for the Technological Surveillance variable. An analysis of the results obtained in the research was carried out, the presence in public universities is reiterated, however, there is evidence of weakness in the activities for the positioning of the Technology Watch.
Student perception of the use of ICT on learning Morphophysiology
Authors: Quintana A 
Published: June 2020

Abstract
The possibility of working in Morphology using the Technologies of Information and Communication promoting an interactive process focused on the student, who does not leave dependence, sometimes excessive, of the teachers to achieve the objectives. The general objective was to determine the importance of the use of ICT in Morphophysiology learning. A cross-sectional descriptive study with a quantitative approach was carried out. The results of the application of a questionnaire that collected the information in several dimensions. A number of 90 people were surveyed, which accounts for 32% of the population of morphology and physiology basic science students of the Nursing, Surgical Instrumentation and Prehospital Care programs of the Rafael Núñez University Corporation of Cartagena, in the period between February and June 2018. The results show that the use of ICT to support Morphophysiology learning is very well received by students and favors the learning in health sciences. ICT are tools that validate and support the observation and experimentation in the laboratory simulation.
Building a prototype for functional analysis of the energy potential of the water flow in pipe ½ “using microturbines applied to Unidades Tecnológicas de Santander
Authors: Ascanio-Villabona J G , Sandoval-Rodriguez C L , Rincón-Quintero A D , Tarazona-Romero B E , Paez-Castro R E 
Published: June 2020

Abstract
The project aims to build a working prototype for analysis of potential energy of water flow in pipe ½ “by using micro tangential turbines with a loss running low, constituting a small-scale model for the study power generation thereof, setting parameters related to a hydraulic distribution system operation residential drinking water. Taking advantage of the electric power, a microturbine is obtained by decanting flow through it. The research methodology is descriptive quantitative approach, to develop the project initially performed a literature review, followed by identification of the electrical variables and characteristics of the prototype to generate a simulation of a real hydraulic circuit, it followed this comes the recognition and selection of the elements for retrofitting. Thus, as looking through prototype and analysis of the energy potential, generating an academic, social and environmental impact on the institution; since being pioneers in this type of project it is expected to generate the conceptual foundations in the community, enabling understanding of the use of this resource and future implementation. social and environmental in the institution; since being pioneers in this type of project it is expected to generate the conceptual foundations in the community, enabling understanding of the use of this resource and future implementation. social and environmental in the institution; since being pioneers in this type of project it is expected to generate the conceptual foundations in the community, enabling understanding of the use of this resource and future implementation.
Structural analysis of a food truck subjected to impact loads
Authors: Argüello Édison , Donoso Caterine , Arteaga Oscar , Chiluisa Kléber , Hernán Morales V , Aguirre Ronny P , Perez Kevin , Morales Klever D 
Published: June 2020

Abstract
The article focuses on the evaluation of impact loads to the structural design of a conventional food truck through static lateral collision tests with dynamic and static study based on several requirements and regulations of the international standard (ECER95) where force determine of impact generated laterally in a totally inelastic. The physical variables that interact in this phenomenon with the variation of mass, velocity and determine their real impact are analyzed with mathematical equations. The validation of the combined loads was developed by CAE software applying the LRFD method complying with Regulation No. 95 of the Economic Commission for Europe (UNECE) of the United Nations with a collision between the stationary conventional food truck and a vehicle, which impacts it at 50 km / h where the deformations under United Nations Regulations No. 95 and No. 66 are determined, guaranteeing the occupants survival.
Comparison of 3D printed trabecular structure with porous plasma spray: A method based on mapping the local modulus of elasticity
Authors: Cvrček Ladislav , Denk František , Čejka Zdeněk 
Published: June 2020

Abstract
The surface of orthopaedic bone implants is in most cases formed by porous plasma spray. The introduction of 3D printing into the production of implants has made it possible to replace plasma spray with a trabecular bone-like structure that can be fabricated by 3D printing. The principle is to create a suitable surface porosity for anchoring the implant in the bone and adapting the modulus of elasticity to the bone properties. The elastic behaviour of both the structures can be compared by means of a compression test, but it is not possible to compare the modulus of elasticity at the local sites. The aim of the work was to verify the possibility to use the nanoindentation method for the local testing of the modulus of elasticity. The selected method made it possible to map the so-called reduced modulus of elasticity at the precisely defined places. Specifically, the 3D printed trabecular structure of Ti6Al4V ELI was compared with titanium plasma spraying. The printed structure with a bulk porosity of 77% showed the local modulus of elasticity in the range of 57–97 GPa depending on the test site. In contrast, for the plasma spray with a volume porosity of 28%, the modulus of elasticity was around the average value of 54 GPa. At the same time, the microstructure and chemical composition were analysed at the critical points of the structure crossover or the transition from the bulk material to the trabecular structure. No change in the microstructure or chemical composition was observed. Both structures bring the modulus of elasticity closer to the bone modulus of elasticity, but 3D printing offers more possibilities to modify the elastic behaviour and the shape and pore size as well.
Effect of Sn content on the mechanical properties and corrosion behavior of Mg-3Al-xSn alloys
Authors: Yu Zhaochen , Huang Qianfei , Zhang Wentao , Luo Chao , Guan Hongyu , Chen Yang , Song Honggun , Hu Zhi , Luc Chassagne 
Published: June 2020

Abstract
The effect of Sn content on the mechanical properties and corrosion behavior of Mg-3Al-xSn alloys was investigated by SEM-EDXS, XRD, electrochemical measurements, and scanning Kelvin probe force microscopy (SKPFM). The results showed that when the Sn content was 1.4 wt%, Sn dissolved in the α-Mg matrix and then precipitated as an intermetallic compound (Mg2Sn). The combined results of mass loss, hydrogen evolution, and electrochemical measurements indicated that Mg-3Al-1Sn had a low corrosion rate. The SKPFM results showed that the Volta potential of Mg2Sn particles, Al-Mn, and β-Mg17Al12 phases were 100, 80, and 50 mV higher than the matrix, respectively. Therefore, the Mg2Sn phase that formed in Mg-3Al-xSn served as a local cathode due to its high potential, which accelerated microgalvanic corrosion along with the secondary local cathode (Al-Mn). The Sn solution strengthening and secondary phase strengthening (fine Mg2Sn particles) improved the mechanical properties of the Mg-3Al-xSn alloys.
matFR: a MATLAB toolbox for feature ranking
Authors: Zhang Zhicheng , Liang Xiaokun , Qin Wenjian , Yu Shaode , Xie Yaoqin 
Published: June 2020

Abstract

Summary
Nowadays, it is feasible to collect massive features for quantitative representation and precision medicine, and thus, automatic ranking to figure out the most informative and discriminative ones becomes increasingly important. To address this issue, 42 feature ranking (FR) methods are integrated to form a MATLAB toolbox (matFR). The methods apply mutual information, statistical analysis, structure clustering and other principles to estimate the relative importance of features in specific measure spaces. Specifically, these methods are summarized, and an example shows how to apply a FR method to sort mammographic breast lesion features. The toolbox is easy to use and flexible to integrate additional methods. Importantly, it provides a tool to compare, investigate and interpret the features selected for various applications.

Availability and implementation
The toolbox is freely available at http://github.com/NicoYuCN/matFR. A tutorial and an example with a dataset are provided.
Fear and Uncertainty: The Surrogacy Triad’s Experience of Social Workers’ Role Ambiguity
Authors: Walker Ruth , van Zyl Liezl 
Published: June 2020

Abstract
In New Zealand, as in the UK, the surrogate is the legal mother of the child until parentage is transferred by the court to the intended parents. Social workers are responsible for assessing the intended parents’ suitability to parent and scrutinising the arrangement. However, courts almost invariably transfer parentage, regardless of their recommendations, with the result that social workers experience a significant amount of role ambiguity. We conducted semi-structured interviews with surrogates and intended parents about their experience of surrogacy in New Zealand, focussing on the changes they would like to see in the regulatory framework, particularly with regards to legal parentage and the involvement of social workers in assessing intending parents’ suitability to parent. Thematic analysis of interview transcripts showed that role ambiguity and role conflict experienced by social workers have their corollary in the experience of intended parents and surrogates, where it manifests as either fear that the adoption could be declined or uncertainty about the purpose of the social worker’s involvement. Although participants recommended that their role be eliminated—along with the adoption process itself—we argue that there is a valuable role for social workers at the beginning of the process.
Tactile direction discrimination in humans after stroke
Authors: Lundblad Linda C , Olausson Håkan , Wasling Pontus , Jood Katarina , Wysocka Anna , Hamilton J Paul , McIntyre Sarah , Backlund Wasling Helena 
Published: June 2020

Abstract
Sensing movements across the skin surface is a complex task for the tactile sensory system, relying on sophisticated cortical processing. Functional MRI has shown that judgements of the direction of tactile stimuli moving across the skin are processed in distributed cortical areas in healthy humans. To further study which brain areas are important for tactile direction discrimination, we performed a lesion study, examining a group of patients with first-time stroke. We measured tactile direction discrimination in 44 patients, bilaterally on the dorsum of the hands and feet, within 2 weeks (acute), and again in 28 patients 3 months after stroke. The 3-month follow-up also included a structural MRI scan for lesion delineation. Fifty-nine healthy participants were examined for normative direction discrimination values. We found abnormal tactile direction discrimination in 29/44 patients in the acute phase, and in 21/28 3 months after stroke. Lesions that included the opercular parietal area 1 of the secondary somatosensory cortex, the dorsolateral prefrontal cortex or the insular cortex were always associated with abnormal tactile direction discrimination, consistent with previous functional MRI results. Abnormal tactile direction discrimination was also present with lesions including white matter and subcortical regions. We have thus delineated cortical, subcortical and white matter areas important for tactile direction discrimination function. The findings also suggest that tactile dysfunction is common following stroke.
Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function
Authors: Wei Pei , Zhong Chenjian , Yang Xiaolan , Shu Futing , Xiao Shichu , Gong Teng , Luo Pengfei , Li Li , Chen Zhaohong , Zheng Yongjun , Xia Zhaofan 
Published: June 2020

Abstract

Background
Diabetic wounds are one of the most common and serious complications of diabetes mellitus, characterized by the dysfunction of wound-healing-related cells in quantity and quality. Our previous studies revealed that human amniotic epithelial cells (hAECs) could promote diabetic wound healing by paracrine action. Interestingly, numerous studies demonstrated that exosomes derived from stem cells are the critical paracrine vehicles for stem cell therapy. However, whether exosomes derived from hAECs (hAECs-Exos) mediate the effects of hAECs on diabetic wound healing remains unclear. This study aimed to investigate the biological effects of hAECs-Exos on diabetic wound healing and preliminarily elucidate the underlying mechanism.

Methods
hAECs-Exos were isolated by ultracentrifugation and identified by transmission electron microscopy, dynamic light scattering and flow cytometry. A series of in vitro functional analyses were performed to assess the regulatory effects of hAECs-Exos on human fibroblasts (HFBs) and human umbilical vein endothelial cells (HUVECs) in a high-glycemic microenvironment. High-throughput sequencing and bioinformatics analyses were conducted to speculate the related mechanisms of actions of hAECs-Exos on HFBs and HUVECs. Subsequently, the role of the candidate signaling pathway of hAECs-Exos in regulating the function of HUVECs and HFBs, as well as in diabetic wound healing, was assessed.

Results
hAECs-Exos presented a cup- or sphere-shaped morphology with a mean diameter of 105.89 ± 10.36 nm, were positive for CD63 and TSG101 and could be internalized by HFBs and HUVECs. After that, hAECs-Exos not only significantly promoted the proliferation and migration of HFBs, but also facilitated the angiogenic activity of HUVECs in vitro. High-throughput sequencing revealed enriched miRNAs of hAECs-Exos involved in wound healing. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses have shown that the target genes of the top 15 miRNAs were highly enriched in the PI3K-AKT pathway. Further functional studies demonstrated that the PI3K-AKT-mTOR pathway was necessary for the induced biological effects of hAECs-Exos on HFBs and HUVECs, as well as on wound healing, in diabetic mice.

Conclusions
Our findings demonstrated that hAECs-Exos represent a promising, novel strategy for diabetic wound healing by promoting angiogenesis and fibroblast function via activation of the PI3K-AKT-mTOR pathway.
Interplay between estrogen and Stat3/NF-κB-driven immunomodulation in lung cancer
Authors: Deng Shanshan , Ramos-Castaneda Marco , Velasco Walter V , Clowers Michael J , Gutierrez Berenice A , Noble Oscar , Dong Yiping , Zarghooni Melody , Alvarado Lucero , Caetano Mauricio S , Yang Shuanying , Ostrin Edwin J , Behrens Carmen , Wistuba Ignacio I , Stabile Laura P , Kadara Humam , Watowich Stephanie S , Moghaddam Seyed Javad 
Published: June 2020

Abstract
K-ras mutant lung adenocarcinoma (LUAD) is the most common type of lung cancer, displays abysmal prognosis and is tightly linked to tumor-promoting inflammation, which is increasingly recognized as a target for therapeutic intervention. We have recently shown a gender-specific role for epithelial Stat3 signaling in the pathogenesis of K-ras mutant LUAD. The absence of epithelial Stat3 in male K-ras mutant mice (LR/Stat3Δ/Δ mice) promoted tumorigenesis and induced a nuclear factor-kappaB (NF-κB)-driven pro-tumor immune response while reducing tumorigenesis and enhancing anti-tumor immunity in female counterparts. In the present study, we manipulated estrogen and NF-κB signaling to study the mechanisms underlying this intriguing gender-disparity. In LR/Stat3Δ/Δ females, estrogen deprivation by bilateral oophorectomy resulted in higher tumor burden, an induction of NF-κB-driven immunosuppressive response, and reduced anti-tumor cytotoxicity, whereas estrogen replacement reversed these changes. On the other hand, exogenous estrogen in males successfully inhibited tumorigenesis, attenuated NF-κB-driven immunosuppression and boosted anti-tumor immunity. Mechanistically, genetic targeting of epithelial NF-κB activity resulted in reduced tumorigenesis and enhanced the anti-tumor immune response in LR/Stat3Δ/Δ males, but not females. Our data suggest that estrogen exerts a context-specific anti-tumor effect through inhibiting NF-κB-driven tumor-promoting inflammation and provide insights into developing novel personalized therapeutic strategies for K-ras mutant LUAD.
What methods are being used to create an evidence base on the use of laboratory tests to monitor long-term conditions in primary care? A scoping review
Authors: Elwenspoek Martha M C , Scott Lauren J , Alsop Katharine , Patel Rita , Watson Jessica C , Mann Ed , Whiting Penny 
Published: June 2020

AbstractBackgroundStudies have shown unwarranted variation in test ordering among GP practices and regions, which may lead to patient harm and increased health care costs. There is currently no robust evidence base to inform guidelines on monitoring long-term conditions.ObjectivesTo map the extent and nature of research that provides evidence on the use of laboratory tests to monitor long-term conditions in primary care, and to identify gaps in existing research.MethodsWe performed a scoping review—a relatively new approach for mapping research evidence across broad topics—using data abstraction forms and charting data according to a scoping framework. We searched CINAHL, EMBASE and MEDLINE to April 2019. We included studies that aimed to optimize the use of laboratory tests and determine costs, patient harm or variation related to testing in a primary care population with long-term conditions.ResultsNinety-four studies were included. Forty percent aimed to describe variation in test ordering and 36% to investigate test performance. Renal function tests (35%), HbA1c (23%) and lipids (17%) were the most studied laboratory tests. Most studies applied a cohort design using routinely collected health care data (49%). We found gaps in research on strategies to optimize test use to improve patient outcomes, optimal testing intervals and patient harms caused by over-testing.ConclusionsFuture research needs to address these gaps in evidence. High-level evidence is missing, i.e. randomized controlled trials comparing one monitoring strategy to another or quasi-experimental designs such as interrupted time series analysis if trials are not feasible.
Structure-based identification of small molecules against influenza A virus endonuclease: an in silico and in vitro approach
Authors: K. Sai Disha , Puranik Rashmi , N. Sudheesh , K. Kavitha , Fathima Fajeelath , K. R. Anu , Joseph Alex , J. Anitha , Arunkumar G , Mudgal Piya Paul 
Published: June 2020

ABSTRACT
Influenza viruses are known to cause acute respiratory illness, sometimes leading to high mortality rates. Though there are approved influenza antivirals available, their efficacy has reduced over time, due to the drug resistance crisis. There is a perpetual need for newer and better drugs. Drug screening based on the interaction dynamics with different viral target proteins has been a preferred approach in the antiviral drug discovery process. In this study, the FDA approved drug database was virtually screened with the help of Schrödinger software, to select small molecules exhibiting best interactions with the influenza A virus endonuclease protein. A detailed cytotoxicity profiling was carried out for the two selected compounds, cefepime and dolutegravir, followed by in vitro anti-influenza screening using plaque reduction assay. Cefepime showed no cytotoxicity up to 200 μM, while dolutegravir was non-toxic up to 100 μM in Madin–Darby canine kidney cells. The compounds did not show any reduction in viral plaque numbers indicating no anti-influenza activity. An inefficiency in the translation of the molecular interactions into antiviral activity does not necessarily mean that the molecules were inactive. Nevertheless, testing the molecules for endonuclease inhibition per se can be considered a worthwhile approach.