bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly stretchable sensing array for independent detection of pressure and strain exploiting structural and resistive control
Authors: Matsuda Ryosuke , Mizuguchi Satoru , Nakamura Fumika , Endo Takuma , Isoda Yutaka , Inamori Go , Ota Hiroki 
Published: July 2020

AbstractStretchable physical sensors are crucial for the development of advanced electrical systems, particularly wearable devices and soft robotics. Currently available stretchable sensors that detect both pressure and strain are based on piezoelectric, piezoresistive, or piezocapacitive effects. The range of pressure sensing is 1–800 kPa with large deformations being within the range of deformations of parts of the human body, such as elbows and knees. However, these devices cannot easily allow simultaneous and independent detection of pressure and strain with sensor arrays at large tensions (> 50%) because strain affects the pressure signal. In this study, we propose a monolithic silicone-based array of pressure and strain sensors that can simultaneously and independently detect the in-plane biaxial tensile deformation and pressure. To realize these functionalities, the deformation of the device structure was optimized using a hetero-silicone substrate made of two types of silicone with different hardness characteristics and porous silicone bodies. In addition, the resistances of the sensors were controlled by adjusting a mixture based on carbon nanoparticles to improve the sensitivity and independence between the pressure and strain sensors. These concepts demonstrate the potential of this approach and its compatibility with the current architectures of stretchable physical sensors.
Analysis of regional economic development based on land use and land cover change information derived from Landsat imagery
Authors: Chen Chao , He Xinyue , Liu Zhisong , Sun Weiwei , Dong Heng , Chu Yanli 
Published: July 2020

AbstractThe monitoring of economic activities is of great significance for understanding regional economic development level and policymaking. As the carrier of economic activities, land resource is an indispensable production factor of economic development, and economic growth leads to increased demand for land as well as changes in land utilization form. As an important means of earth observation, remote-sensing technology can obtain the information of land use and land cover change (LUCC) related to economic activities. This study proposes a method for analysing regional economic situations based on remote-sensing technology, from which LUCC information extraction, sensitivity factor selection, model construction and accuracy evaluation were implemented. This approach was validated with experiments in Zhoushan City, China. The results show that the economic statistical index is most sensitive to the construction land area, and the average correlation coefficient between the actual data and the predicted data is 0.949, and the average of mean relative error is 14.21%. Therefore, this paper suggests that LUCC could be utilised as an explanatory indicator for estimating economic development at the regional level, and the potential applications of remotely-sensed image in economic activity monitoring are worth pursuing.
Cationic amphiphilic alternating copolymers with tunable morphology
Authors: Zhang Jingling , Yu Xiaoxi , Zheng Bingqian , Shen Jiachun , Bhatia Surita R. , Sampson Nicole S. 
Published: July 2020

A series of ionic amphiphilic alternating copolymers were characterized via SAXS, TEM and DLS to understand how factors such as covalent structure, and solvent environment affect self-assembly.
Loss of Mef2D function enhances TLR induced IL-10 production in macrophages
Authors: Pattison Michael J. , Naik Rangeetha Jayaprakash , Reyskens Kathleen M.S.E. , Arthur J. Simon C. 
Published: July 2020

Abstract
Mef2 transcription factors comprise a family of four different isoforms that regulate a number of processes including neuronal and muscle development. While roles for Mef2C and Mef2D have been described in B-cell development their role in immunity has not been extensively studied. In innate immune cells such as macrophages, TLRs drive the production of both pro- and anti-inflammatory cytokines. IL-10 is an important anti-inflammatory cytokine produced by macrophages and it establishes an autocrine feedback loop to inhibit pro-inflammatory cytokine production. We show here that macrophages from Mef2D knockout mice have elevated levels of IL-10 mRNA induction compared with wild-type cells following LPS stimulation. The secretion of IL-10 was also higher from Mef2D knockout macrophages and this correlated to a reduction in the secretion of TNF, IL-6 and IL-12p40. The use of an IL-10 neutralising antibody showed that this reduction in pro-inflammatory cytokine production in the Mef2D knockouts was IL-10 dependent. As the IL-10 promoter has previously been reported to contain a potential binding site for Mef2D, it is possible that the binding of other Mef2 isoforms in the absence of Mef2D may result in a higher activation of the IL-10 gene. Further studies with compound Mef2 isoforms would be required to address this. We also show that Mef2D is highly expressed in the thymus, but that loss of Mef2D does not affect thymic T-cell development or the production of IFNγ from CD8 T cells.
Features, Functionality, and Acceptability of Internet-Based Cognitive Behavioral Therapy for Tinnitus in the United States
Authors: Manchaiah Vinaya , Vlaescu George , Varadaraj Srinivas , Aronson Elizabeth Parks , Fagelson Marc A. , Munoz Maria F. , Andersson Gerhard , Beukes Eldré W. 
Published: July 2020

Objective
Although tinnitus is one of the most commonly reported symptoms in the general population, patients with bothersome tinnitus are challenged by issues related to accessibility of care and intervention options that lack strong evidence to support their use. Therefore, creative ways of delivering evidence-based interventions are necessary. Internet-based cognitive behavioral therapy (ICBT) demonstrates potential as a means of delivering this support but is not currently available in the United States. This article discusses the adaptation of an ICBT intervention, originally used in Sweden, Germany, and the United Kingdom, for delivery in the United States. The aim of this study was to (a) modify the web platform's features to suit a U.S. population, (b) adapt its functionality to comply with regulatory aspects, and (c) evaluate the credibility and acceptability of the ICBT intervention from the perspective of health care professionals and patients with bothersome tinnitus.

Materials/Method

Initially, the iTerapi ePlatform developed in Sweden was adopted for use in the United States. Functional adaptations followed to ensure that the platform's functional and security features complied with both institutional and governmental regulations and that it was suitable for a U.S. population. Following these adaptations, credibility and acceptance of the materials were evaluated by both health care professionals (
n
= 11) and patients with bothersome tinnitus (
n
= 8).

Results
Software safety and compliance regulatory assessments were met. Health care professionals and patients reported favorable acceptance and satisfaction ratings regarding the content, suitability, presentation, usability, and exercises provided in the ICBT platform. Modifications to the features and functionality of the platform were made according to user feedback.

Conclusions
Ensuring that the ePlatform employed the appropriate features and functionalities for the intended population was essential to developing the Internet-based interventions. The favorable user evaluations indicated that the intervention materials were appropriate for the tinnitus population in the United States.
Depression in Poststroke Aphasia
Authors: Laures-Gore Jacqueline S. , Dotson Vonetta M. , Belagaje Samir 
Published: July 2020

Purpose
The aim of this tutorial is to provide speech-language pathologists with foundational knowledge of poststroke depression comorbidly occurring with aphasia. Given the negative effect of depression on functional outcomes and mortality, it is crucial that speech-language pathologists possess this knowledge in order to better advocate for and treat their patients.

Method and Results
Three areas of complementary expertise (speech-language pathology, psychology, and neurology) collaborated on this tutorial to address the following areas: (a) provide terminology associated with depression and related mood disorders, (b) describe the potential underlying pathophysiology of depression in the general population, (c) provide an overview of our existing understanding of comorbid poststroke depression and aphasia, and (d) summarize current assessment methods and interventions for poststroke depression in adults with aphasia.

Conclusion
Given the compounding impact aphasia and depression have on rehabilitation outcomes, it is imperative that speech-language pathologists understand terminology, assessment, and treatment practices for depression.
Blockchain Enabled Online-Voting System
Authors: Shah Akhil , Sodhia Nishita , Saha Shruti , Banerjee Soumi , Chavan Madhuri 
Published: July 2020

A blockchain-enabled online-voting system is being proposed in this following paper. Blockchain technologies deliver an endless variety of applications that benefit from distributed economies. The proposed model is an android application that has enhanced security features which includes both authentication and authorization. Authentication is incorporated by using a unique identification key and authorization is done by using fingerprint. Voters are also being verified by One-time password. The security in this project is implemented by using a 128 bit AES encryption algorithm and SHA-256 along with blockchain. The vote is casted in the form of transaction, where a blockchain is created, which keeps track of tallies of votes. Through this atomicity and integrity are maintained. [4]
Index Terms—Voting System , Blockchain , SHA-256, Security, AES-128, Ballot
Screening for Occult Cancer in Patients with Venous Thromboembolism: Past, Present, and Future
Authors: van Es Nick , Ay Cihan , Jara-Palomares Luis 
Published: July 2020

AbstractA strong link between cancer and thrombosis has been well recognized. The occurrence of venous thromboembolism (VTE) can be the first clinical sign of an undiagnosed (i.e., occult) cancer. Cancer is more often diagnosed after unprovoked compared with provoked VTE events, with a reported risk in recent studies of around 5%. Extensive, imaging-based screening strategies to detect occult cancer after unprovoked VTE do not appear to have a clear clinical benefit compared with a more limited cancer screening. To identify patients with unprovoked VTE at high risk of occult cancer, risk factors have been explored and prediction models developed. Relevant risk factors for occult cancer include male sex, age, anemia, chronic lung disease, and thrombocytosis. Studies with preselection of patients based on risk assessment and evaluation of limited versus extensive screening strategies are currently ongoing. Also, novel and promising approaches for early detection of cancer in patients with unprovoked VTE by means of liquid biopsies, which include analysis of circulating tumor cells, cell-free tumor DNA, proteomics, or platelet mRNA sequencing, are currently under investigation. In this review, we provide an overview of the risk of cancer diagnosis after VTE, discuss the studies which investigated different screening strategies for occult cancer, summarize risk factors and risk scoring models for identification of patients at high risk of cancer diagnosis after VTE, and highlight ongoing research to optimize screening and identification of patients at risk of occult cancer, which will shape the future clinical practice.
Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment
Authors: Valerio Luca , Riva Nicoletta 
Published: July 2020

AbstractSeptic thrombophlebitis (STP) is a complex, cross-disciplinary clinical condition that combines a localized infection with a neighboring venous thrombosis. STP can occur at several possible anatomic sites, such as dural sinuses, jugular vein (Lemierre syndrome), portal vein (pylephlebitis), and pelvic veins. Its high mortality in the preantibiotic era improved considerably with the introduction of modern antibiotics. However, little evidence exists to date to guide its clinical management. The incidence of STP or its risk factors may be increasing, and its mortality may still be considerable. These trends would have far-reaching implications, especially in the setting of increasing resistance to antimicrobial agents. No clinical assessment tools exist to support patient screening or guide treatment in STP. Few interventional studies exist on the efficacy and safety of anticoagulation. Recommendations on its indications, duration, and the agents of choice are mostly based on evidence derived from small observational studies. While all forms of STP pose similar challenges, future research may benefit from the distinction between bacteria-associated, virus-associated, and mycosis-associated thrombophlebitis. Addressing these gaps in evidence would enhance our ability to diagnose this condition and treat patients effectively.
Colonoscopy-related adverse events and mortality in an Italian organized colorectal cancer screening program
Authors: Benazzato Luca , Zorzi Manuel , Antonelli Giulio , Guzzinati Stefano , Hassan Cesare , Fantin Alberto ,   and the Veneto Screening Endoscopists Working Group
Published: July 2020

Abstract
Background Post-colonoscopy adverse events are a key quality indicator in population-based colorectal cancer screening programs, and affect safety and costs. This study aimed to assess colonoscopy-related adverse events and mortality in a screening setting.
Methods We retrieved data from patients undergoing colonoscopy within a screening program (fecal immunochemical test every 2 years, 50–69-year-olds, or post-polypectomy surveillance) in Italy between 2002 and 2014, to assess the rate of post-colonoscopy adverse events and mortality. Any admission within 30 days of screening colonoscopy was reviewed to capture possible events. Mortality registries were also matched with endoscopy databases to investigate 30-day post-colonoscopy mortality. Association of each outcome with patient-/procedure-related variables was assessed using multivariable analysis.
Results Overall, 117 881 screening colonoscopies (66 584, 56.5 %, with polypectomy) were included. Overall, 497 (0.42 %) post-colonoscopy adverse events occurred: 281 (0.24 %) bleedings (3.69‰/0.68‰, operative/diagnostic procedures) and 65 (0.06 %) perforations (0.75‰/0.29‰, respectively). At multivariable analysis, bleeding was associated with polyp size (≥ 20 mm: odds ratio [OR] 16.29, 95 % confidence interval [CI] 9.38–28.29), proximal location (OR 1.46, 95 %CI 1.14–1.87), and histology severity (high risk adenoma: OR 5.6, 95 %CI 2.43–12.91), while perforation was associated with endoscopic resection (OR 2.91, 95 %CI 1.62–5.22), polyp size (OR 4.34, 95 %CI 1.46–12.92), and proximal location (OR 1.94, 95 %CI 1.12–3.37). Post-colonoscopy mortality occurred in 15 /117 881 cases (1.27/10 000 colonoscopies).
Conclusions In an organized screening program, post-colonoscopy adverse events were rare but not negligible. The most frequent event was post-polypectomy bleeding, especially after resection of large (≥ 20 mm) and proximal lesions.
Diurnal Variation and Nursing Perspectives in Analgesic and Sedation Medication Administration to Mechanically Ventilated Children in a Single Pediatric ICU
Authors: Loberger Jeremy M. , Rockwell Nicholas , Daniel Laura , Aban Inmaculada B. , Prabhakaran Priya 
Published: July 2020

AbstractThe primary objective of this study was to determine whether there was diurnal variation in the amount of analgesic and sedation medication administered to mechanically ventilated children in a single pediatric intensive care unit (PICU). The secondary objective was to evaluate nursing attitudes and practices regarding administration of these medications. This was a prospective, longitudinal cohort study of mechanically ventilated patients admitted to a single PICU. There were 46 mechanical ventilation courses included (305 paired day–night shifts). There was no significant diurnal variation found in the amount of analgesics and sedatives administered to mechanically ventilated patients. However, the reasons for administration differed between day and night shifts.
Chronic Obstructive Pulmonary Disease and Lung Transplantation
Authors: Greer Mark , Welte Tobias 
Published: July 2020

AbstractLung transplantation (LTx) has been a viable option for patients with end-stage chronic obstructive pulmonary disease (COPD), with more than 20,000 procedures performed worldwide. Survival after LTx lags behind most other forms of solid-organ transplantation, with median survival for COPD recipients being a sobering 6.0 years. Given the limited supply of suitable donor organs, not all patients with end-stage COPD are candidates for LTx. We discuss appropriate criteria for accepting patients for LTx, as well as contraindications and exclusionary criteria. In the first year post-LTx, infection and graft failure are the leading causes of death. Beyond this chronic graft rejection—currently referred to as chronic lung allograft dysfunction—represents the leading cause of death at all time points, with infection and over time malignancy also limiting survival. Referral of COPD patients to a lung transplant center should be considered in the presence of progressing disease despite maximal medical therapy. As a rule of thumb, a forced expiratory volume in 1 second < 25% predicted in the absence of exacerbation, hypoxia (PaO2 < 60 mm Hg/8 kPa), and/or hypercapnia (PaCO2 > 50 mm Hg/6.6 kPa) and satisfactory general clinical condition should be considered the basic prerequisites for timely referral. We also discuss salient issues post-LTx and factors that impact posttransplant survival and morbidity such as infections, malignancy, renal insufficiency, and complications associated with long-term immunosuppression.
An Electronic Medical Record-Derived Individualized Performance Metric to Measure Risk-Adjusted Adherence with Perioperative Prophylactic Bundles for Health Care Disparity Research and Implementation Science
Authors: Andreae Michael H. , Maman Stephan R. , Behnam Abrahm J. 
Published: July 2020

Abstract
Background Health care disparity persists despite vigorous countermeasures. Clinician performance is paramount for equitable care processes and outcomes. However, precise and valid individual performance measures remain elusive.
Objectives We sought to develop a generalizable, rigorous, risk-adjusted metric for individual clinician performance (MIP) derived directly from the electronic medical record (EMR) to provide visual, personalized feedback.
Methods We conceptualized MIP as risk responsiveness, i.e., administering an increasing number of interventions contingent on patient risk. We embedded MIP in a hierarchical statistical model, reflecting contemporary nested health care delivery. We tested MIP by investigating the adherence with prophylactic bundles to reduce the risk of postoperative nausea and vomiting (PONV), retrieving PONV risk factors and prophylactic antiemetic interventions from the EMR. We explored the impact of social determinants of health on MIP.
Results We extracted data from the EMR on 25,980 elective anesthesia cases performed at Penn State Milton S. Hershey Medical Center between June 3, 2018 and March 31, 2019. Limiting the data by anesthesia Current Procedural Terminology code and to complete cases with PONV risk and antiemetic interventions, we evaluated the performance of 83 anesthesia clinicians on 2,211 anesthesia cases. Our metric demonstrated considerable variance between clinicians in the adherence to risk-adjusted utilization of antiemetic interventions. Risk seemed to drive utilization only in few clinicians. We demonstrated the impact of social determinants of health on MIP, illustrating its utility for health science and disparity research.
Conclusion The strength of our novel measure of individual clinician performance is its generalizability, as well as its intuitive graphical representation of risk-adjusted individual performance. However, accuracy, precision and validity, stability over time, sensitivity to system perturbations, and acceptance among clinicians remain to be evaluated.
Mixed phase transition from hypernuclear matter to deconfined quark matter fulfilling mass-radius constraints of neutron stars
Authors: Shahrbaf M , Blaschke D , Khanmohamadi S 
Published: July 2020

Abstract
A recent solution of the hyperon puzzle by a first order phase transition to color superconducting quark matter is revisited in order to replace the Maxwell construction by an interpolation method which describes a mixed phase. To do this, we apply for the first time the finite-range polynomial interpolation method for constructing a transition between hadronic and quark matter phases to the situation that is characterized in the literature as the reconfinement problem. For the description of the hadronic phase the lowest order constrained variational method is used while for the quark phase the nonlocal Nambu–Jona–Lasinio model with constant and with density-dependent parameters is employed. Applying the replacement interpolation method to both quark matter models results in a hybrid equation of state that allows a coexistence of nuclear matter, hypernuclear matter and quark matter in a mixed phase between the pure hadronic and quark phases which can also be realized in the structure of the corresponding hybrid star sequences. The predicted hybrid stars fulfill the constraints on the mass-radius relation for neutron stars obtained from recent observations.
Algorithm for automatic detection and measurement of Vickers indentation hardness using image processing
Authors: Domínguez-Nicolas S M , Herrera-May A L , García-González L , Zamora-Peredo L , Hernández-Torres J , Martínez-Castillo J , Morales-González E A , Cerón-Álvarez C A , Escobar-Pérez A 
Published: July 2020

Abstract
In this paper, we present a novel algorithm for the automatic detection and measurement of Vickers indentation hardness, using image processing. This algorithm uses image segmentation via binarization, automatically evaluating the mean and extreme gray values by means of standard histogram equalization so as to determine the optimal binarization threshold from each input image. We use a morphological filter and region growing to identify the indentation footprint. Our algorithm determines the four indentation vertices required to calculate diagonal lengths and Vickers hardness number. This algorithm is applied to 230 indentation images of steel-316 and hafnium nitride specimens, obtained using a micro hardness machine. The proposed algorithm can measure the Vickers hardness number of specimens using their indentation images. The algorithm results have a relative error of less than 3% with respect to those obtained through a conventional manual procedure. This algorithm can be used for indentation images with low contrast and irregular indentation edges.