bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constricted migration is associated with stable 3D genome structure differences in cancer cell
Authors: Golloshi Rosela , Playter Christopher , Freeman Trevor F. , Das Priyojit , Raines Thomas Isaac , Garretson Joshua H. , Thurston Delaney , McCord Rachel Patton 
Published: November 2019

AbstractTo spread from a localized tumor, metastatic cancer cells must squeeze through constrictions that cause major nuclear deformations. Since chromosome structure affects nucleus stiffness, gene regulation and DNA repair, here we investigate the relationship between 3D genome structure and constricted migration in cancer cells. Using melanoma (A375) cells, we identify phenotypic differences in cells that have undergone multiple rounds of constricted migration. These cells display a stably higher migration efficiency, elongated morphology, and differences in the distribution of Lamin A/C and heterochromatin. Hi-C experiments reveal differences in chromosome spatial compartmentalization specific to cells that have passed through constrictions and related alterations in expression of genes associated with migration and metastasis. Certain features of the 3D genome structure changes, such as a loss of B compartment interaction strength, are consistently observed after constricted migration in clonal populations of A375 cells and in MDA-MB-231 breast cancer cells. Our observations suggest that consistent types of chromosome structure changes are induced or selected by passage through constrictions and that these may epigenetically encode stable differences in gene expression and cellular migration phenotype.
Strangers in a seemingly open-to-all website: the gender bias in Wikipedia
Authors: Lir Shlomit Aharoni 
Published: November 2019

Purpose
Throughout the years, many scholarly answers were given to the question regarding the gender bias in Wikipedia. However, the research literature seldom explores how different barriers are interconnected and rarely focuses on what prevents women who initially declared their interest from eventually participating in the website. The purpose of this paper is to deal with this lacuna and explore the gender bias in Wikipedia through examining how the different barriers are interlinked in a manner that deters women and prevents them from editing in the website.

Design/methodology/approach
Based on action research with a mixed evaluation method and two rounds of interviews, the research followed the steps of 27 Israeli women activists who participated in editing workshops.

Findings
The findings show that having the will to edit and the knowledge of how to edit are necessary but insufficient conditions for women to participate in Wikipedia. The finding reveals two categories: pre-editing barriers of negative reputation, lack of recognition, anonymity and fear of being erased; and post-editing barriers of experiences of rejection, alienation, lack of time and profit and ownership of knowledge. The research suggests a “Vicious Circle” model, displaying how the five layers of negative reputation, anonymity, fear, alienation and rejection – enhance each other, in a manner that deters women from contributing to the website.

Practical implications
In order for more women to join Wikipedia, the research offers the implantation of a “Virtuous Circle” that consists of nonymity, connection to social media, inclusionist policy, soft deletion and red-flagging harassments.

Originality/value
Throughout the years, many answers were given to the question regarding the gender bias in Wikipedia. However, research literature seldom explores how different barriers are interconnected and rarely focuses on what prevents women who initially declared their interest and who attended editing workshops from eventually participating in the website. The current research has taken upon itself to deal with this lacuna and explores the power-relations in Wikipedia through three questions: first, why an educational intervention did not increase participation? Second, how the different barriers described by research group members are interconnected and enhance each other in a manner that prevents women from editing on the website? and third how can the gap be narrowed?
An investigation of the relationship between lean and well-being based on the job demands-resources model
Authors: Beraldin Andrea Roberto , Danese Pamela , Romano Pietro 
Published: November 2019

PurposeThe purpose of this paper is to investigate how just-in-time (JIT)-related job demands, problem-solving job demands and soft lean practices (SLPs) jointly influence employee well-being in terms of work engagement and exhaustion.Design/methodology/approachBased on the job demands-resources model, lean-related job characteristics were classified as resources or demands, and a set of hypotheses was developed to test their effect on work engagement and exhaustion, including the potential interaction between job resources and demands. The hypotheses were tested using moderated hierarchical regression and structural equation modelling, based on data from 138 workers.FindingsSLPs act as job resources in a lean company, increasing work engagement and reducing exhaustion. Conversely, JIT-related job demands act as a hindrance, reducing work engagement and increasing exhaustion. However, SLPs can reduce the effect of JIT-related job demands on exhaustion, and JIT-related job demands may enhance the positive effects of SLPs on work engagement.Research limitations/implicationsThe study provides no conclusive evidence on the hypothesized role of problem-solving as a challenge job demand.Practical implicationsThe results can guide practitioners’ understanding of how to implement lean without harm to employee well-being.Originality/valueBy employing a well-grounded psychological model to test the link between lean and well-being, the study finds quantitative support for: the buffering effect of SLPs on exhaustion caused by JIT-related job demands, and for the role of JIT as a hindrance. These novel findings have no precedent in previous survey-based research. In addition, it reveals the importance of studying SLPs at an individual level, as what matters is the extent to which workers perceive SLPs as useful and supportive.
Collaboration for transition between TVET and university: a proposal
Authors: Naziz Arjuman 
Published: November 2019

PurposeDespite the growing emphasis on revitalizing the technical and vocational education and training (TVET) sector in Bangladesh, very little discussion has taken place on reforming the current inflexible transition pathways, from TVET to the universities. This paper aims to reflect critically on the existing literature on TVET, in the global and national context, and the experiences of students and TVET experts, to develop a model of collaboration between the polytechnic institutes and the universities in Bangladesh.Design/methodology/approachThis paper follows a qualitative strategy of enquiry, using a mix of critical reflection on literature on TVET and higher education and unstructured interviews with two TVET experts, four TVET students and four students from a public university. It draws on the theories of collaboration and uses exemplary cases to illustrate and support the line of reasoning.FindingsThis paper identifies that there is resource dependency between the polytechnic institutes and universities in Bangladesh, and their institutional environment necessitates them to form collaboration to ensure flexible transition pathway, from polytechnic institutes to universities; this paper proposes a model for such collaboration.Practical implicationsThis paper offers a guideline for forming collaboration among the relevant stakeholders.Social implicationsCollaboration between polytechnic institutes and universities in Bangladesh is likely to address the inequitable nature of TVET, by improving its social status and acceptance, as well as allowing higher income opportunity and greater mobility for the TVET graduates, coming especially from humble socio-economic backgrounds.Originality/valueThis paper contributes in the recent discussions on how collaboration among different stakeholders can contribute in achieving the sustainable development goals, with special emphasis on TVET.
Savings operations with random commencement and conclusion
Authors: Valls Martínez María del Carmen , Cruz Rambaud Salvador , Abad Segura Emilio 
Published: November 2019

Purpose
The progressive aging of the population is suggesting that public pension plans should be increasingly supplemented by private savings schemes. Accordingly, this supposes the appearance of a wide range of innovative savings products to meet the varying needs of savers and financial institutions. In practice, most contracted savings operations are nonrandom, that is to say, all amounts involved in the transaction are sure as well as their respective maturities. Consequently, the purpose of this paper is to propose a savings operation which includes the randomness derived from the contingencies which suppose the eventual but unpredictable death of the saver and a person designated by him to receive the final agreed amount.

Design/methodology/approach
The methodology used in this paper is financial mathematics where the risk has been introduced as an element which defines the main characteristics of this novel saving operation.

Findings
The proposed model extends the range of savings products by describing an actual innovation with new practical applications with respect to the traditional models of saving. In this paper, the authors have proposed a new type of saving based on the contingency derived from the life expectancy of the saver, by raising an operation in which the commencement and conclusion of the savings period are random. These savings operations represent, undoubtedly, a novelty from a financial point of view.

Originality/value
The main added value of this paper is that these contingencies affect the periodic deposits in each period from the first to the last maturities of installments. Moreover, the different parameters of such random transactions are defined.
Dynamics of credit decision-making: a taxonomy and a typological matrix
Authors: Saliya Candauda Arachchige 
Published: November 2019

PurposeThe purpose of this paper is to broaden understanding as to how certain social/personal dynamics influence credit decisions in Sri Lanka, elucidating them through a taxonomy and a conceptual typological matrix.Design/methodology/approachThis research is an exploratory case study. The primary data collection methods are interviews and reconstruction of experiences. The data are complemented by documentary analysis and post-research events.FindingsThe research findings propose that credit officers and customers are influenced by six dynamics under three dimensions: the evaluation procedures (systematic/formal or heuristics); the relationship between customers and bank officers (personal or role relationship); and justification of credit (rational or irrational/situational). Based on the above results, a taxonomy of influential tactics and personality traits and a typological matrix are developed to classify credit decision-makers, who are labelled as BOSS, ROBOT, REBEL and BUDDY.Research limitations/implicationsThese case studies are from a private bank in Sri Lanka, hence it could affect the generalization of findings. Therefore, researchers are encouraged to investigate the plausibility of the findings in diverse cultural backgrounds.Practical implicationsCredit decision-makers and credit applicants could make use of these typological matrix and the taxonomy to understand each other and employ more influential approaches and appropriate influential techniques to make effective credit decisions. It also provides more insight into understanding the nature of credit-decisions and decision-makers and, provokes further research.Originality/valueTo the author’s best knowledge, this is the first study in Sri Lanka that considers certain influencing factors of credit decision-making and proposes a conceptual typology to understand those factors.
Topical administration of nanocarrier miRNA‐210 antisense ameliorates imiquimod‐induced psoriasis‐like dermatitis in mice
Authors: Feng Huan , Wu Ruifang , Zhang Suhan , Kong Yi , Liu Zixin , Wu Haijing , Wang Honglin , Su Yuwen , Zhao Ming , Lu Qianjin 
Published: November 2019

AbstractPsoriasis is a chronic, recurrent inflammatory autoimmune skin disease. Although its etiology and pathogenesis are complex and multifarious, it has been proved to be closely related to dysregulation of immune cell function as well as keratinocyte proliferation/differentiation. Our previous study demonstrated that miRNA‐210 (miR‐210) plays an important role in the formation of skin lesions and immune imbalance in psoriasis. Here, we developed a biomimetic reconstituted high‐density lipoprotein (rHDL) nanocarrier gel containing miR‐210 antisense (NG‐anti‐miR‐210) to investigate its effect on imiquimod (IMQ)‐induced psoriasis‐like dermatitis in mice. We found that topical treatment with NG‐anti‐miR‐210 significantly decreased the expression of miR‐210 in both the skin lesions and splenic CD4+ T cells from IMQ‐induced psoriasis‐like mouse models and ameliorated the dermatitis in terms of the erythema, scales, acanthosis and dermal inflammatory cell infiltration in IMQ‐induced mice. In addition, the proportion of T‐helper (Th)1 and Th17 cells in dermal and splenic cells of IMQ‐treated mice were decreased by application of NG‐anti‐miR‐210, accompanied by decreased interleukin‐17A and γ‐interferon mRNA levels. Therefore, our data demonstrate that topical inhibition of miR‐210 delivered by rHDL nanocarrier effectively alleviates the psoriasis‐like inflammation in mice and provides a potentially effective topical drug for psoriasis.
Challenges in estimating ancestral state reconstructions: the evolution of migration inSylviawarblers as a study case
Authors: PONTI Raquel , ARCONES Angel , VIEITES David R. 
Published: November 2019

AbstractOur current understanding of how species have evolved is mainly based on comparative phylogenetic methods, which use phylogenies to infer the evolution of traits. The development of ancestral state reconstruction (ASR) methods has provided the tools to reconstruct trait evolution, which are widely used in fields like evolutionary biology, macroecology and paleontology. As there are different elements involved in those analyses, with different levels of uncertainty (i.e. relating to branch length estimation, trait coding, statistical framework, taxon sampling or software), the various combinations of these elements likely have a strong impact on the reconstruction of the evolution of traits, potentially leading to opposite conclusions. To assess the impact of these different elements in ASR, we performed a set of analyses, including all possible combinations of such elements and using the evolution of migratory behavior inSylviawarblers as a case study, which was coded as a continuous or as a discrete character. Our results show that taxon sampling, character coding, tree shape, statistical framework and software all significantly affect ASR, both individually and in combination. Not all reconstructed tree nodes show discrepancies, but in the critical ones most pairwise comparisons between analyses lead to conflicting and unexpectedly antagonistic results (zero migrationvsfully migratory), thus challenging interpretations of trait evolution. We propose some possible solutions to partly inform decisions, involving the method selection and the incorporation of biological or fossil evidence regarding how traits evolve, but our results demand serious rethinking about how the research community currently uses ASR.
Offspring birthweight and placental weight in immigrant women from conflict‐zone countries; does length of residence in the host country matter? A population study in Norway
Authors: Eskild Anne , Sommerfelt Silje , Skau Irene , Grytten Jostein 
Published: November 2019

AbstractIntroductionWe aimed to estimate differences in offspring birthweight and placental weight between Norwegian women and immigrants in Norway from countries with armed conflicts. We also studied whether length of residence in Norway was associated with offspring birthweight and placental weight.Material and methodsWe included in our study all singleton births in Norway at gestational week 28 or beyond during the years 1999‐2014, to mothers who were born in Somalia, Afghanistan, Iraq (total immigrants n = 18 817), or Norway (n = 668 439). Data were obtained from The Medical Birth Registry of Norway and the Central Person Registry of Norway. We estimated the differences between Norwegian and immigrant women in mean offspring birthweight and mean placental weight by applying linear regression analyses. Adjustments were made for maternal age, parity, year of delivery, gestational age at delivery, preeclampsia, and diabetes.ResultsThe immigrant women had 206 g (95% CI 199 to 213 g) lower mean offspring birthweight and 16 g (95% CI 14 to 18 g) lower mean placental weight than Norwegian women. Immigrant women with ≥5 years of residence in Norway had higher offspring birthweight (40 g) and higher placental weight (17 g) than immigrant women with <5 years of residence.ConclusionsImmigrant mothers from Somalia, Afghanistan, and Iraq gave birth to infants and placentas with lower weight than Norwegian women. However, the difference between Norwegian women and immigrant women was reduced by length of residence in Norway.
Corporate environmental performance and financing decisions
Authors: Benlemlih Mohammed , Cai Li 
Published: November 2019

AbstractWe investigate the financing strategies of environmentally responsible firms to understand how they set target capital structures and make incremental financing decisions. Literature shows that firms with better environmental performance have lower risk and better access to financing. However, it is not obvious how these firms choose to finance their investments. Using an extensive data set of U.S. firms, we find that firms with superior environmental performance have significantly lower debt ratios and use mostly short‐term debt for temporary financing needs. In doing so, environmentally responsible firms are able to achieve more tax savings and experience lower costs of financial distress. Our results provide new empirical facts about environmental performance and financing decisions, and they help explain the observed relationship between environmental performance and economic performance.
Plasma and tumoral glypican‐3 levels are correlated in patients with hepatitis C virus‐related hepatocellular carcinoma
Authors: Shimizu Yasuhiro , Mizuno Shoichi , Fujinami Norihiro , Suzuki Toshihiro , Saito Keigo , Konishi Masaru , Takahashi Shinichiro , Gotohda Naoto , Tada Toshifumi , Toyoda Hidenori , Kumada Takashi , Miura Masahiro , Suto Kouzou , Yamaji Taiki , Matsuda Takahisa , Endo Itaru , Nakatsura Tetsuya 
Published: November 2019

AbstractGlypican‐3 (GPC3) is a cancer antigen expressed in approximately 80% of hepatocellular carcinomas (HCC) and is secreted into the blood. To confirm the effectiveness of GPC3 as a biomarker in HCC, we analyzed the relationship between GPC3 expression levels in cancer cells and in blood in 56 patients with HCC. Preoperative plasma GPC3 levels were determined with an immunoassay, and expression of GPC3 in resected tumors was analyzed by immunohistochemical staining. Median plasma GPC3 level in all HCC cases was 4.6 pg/mL, and tended to be higher in patients with hepatitis C virus (HCV)‐related HCC (HCV group) (9.9 pg/mL) than in patients with hepatitis B virus (HBV)‐related HCC (HBV group) (2.6 pg/mL) or in those without virus infection (None group) (3.0 pg/mL), suggesting that the virus type most likely influences GPC3 secretion. Median percentage of GPC3+ cells in tumors was also higher in the HCV (26.2%) and HBV (11.1%) groups than in the None group (4.2%). In the HCV group, there was a positive correlation between the two parameters (r = 0.66, P < .01). Moreover, receiver operating characteristic analysis predicted >10% GPC3+ cells in a tumor if the cut‐off value was 6.8 pg/mL (sensitivity 80%, specificity 100%; area under the curve 0.875, 95% confidence interval 0.726‐1) in the HCV group. Plasma concentration of GPC3 could be a predictive marker of tumoral GPC3 expression in patients with HCV‐related HCC, suggesting a useful biomarker for immunotherapies targeting GPC3, although larger‐scale validations are needed.
Earthworms in Brazilian no‐tillage agriculture: Current status and future challenges
Authors: Demetrio Wilian C. , Ribeiro Ricardo H. , Nadolny Herlon , Bartz Marie L.C. , Brown George G. 
Published: November 2019

AbstractNo‐tillage (NT) agriculture represents a great advance in soil conservation in tropical and subtropical zones, occupying more than 32 million ha in Brazil in 2017. No‐tillage systems can promote earthworm populations, which can improve soil physical and chemical properties, thus enhancing the benefits of NT for soil conservation and ecosystem services. Furthermore, earthworms can be used as indicators of the quality of NT systems. Here, we summarize the studies that evaluated earthworm populations in NT systems between 1986 and 2016 in Brazil, highlighting important gaps in knowledge. The studies were highly skewed geographically, with most data from southern and south‐eastern Brazil, and had very little information from the two states with the greatest NT area (Mato Grosso and Rio Grande do Sul) which together represent 43% of Brazilʼs NT area. Abundance values ranged from 0 to 660 ind. m−2, with a mean of 91 ± 129 ind. m−2(±SD), and at least 33 species were identified in NT systems. However, 73% of sites were considered to have poor and moderate soil quality based on their earthworm populations, raising concern regarding soil quality levels in Brazilian NT systems. Climate, soil and management conditions are important drivers of earthworm populations in Brazilian NT systems and future earthworm surveys in NT systems should provide ample data on these attributes, as well as on earthworm species, in order to improve their use as soil quality bioindicators.HighlightsMean earthworm abundance in Brazilian NT is 91 ± 129 ind. m−2(range 0–660 ind. m−2)33 species were identified in NT, most endogeic and epi‐endogeic (0 anecics, 1 epigeic)Around 75% of NT sites sampled in Brazil had moderate to poor earthworm populationsSoil management practices need improvement in many NT systems to increase earthworm populations
An experimental study of creep‐ratchetting behavior of rolled AZ31B magnesium alloy at room temperature
Authors: Meng Li , Chen Wufan , Feng Miaolin 
Published: November 2019

AbstractTo study the interaction effect of creep and ratchetting for rolled AZ31B magnesium alloy at room temperature, a series of stress‐controlled tests were designed. In the tests, four loading types with different mean stresses were considered, and dwell loading was applied to explore the creep effect on the ratchetting. The test results indicated that the sequence of ratchetting and creep loading is crucial for the strain evolution. The amount of twinning/detwinning increased as the mean stress decreased, leading to an exhaustion of nonbasal slip during ratchetting, and then suppressed the creep ductility. However, the creep sequence exerted little influence on the strain shift of ratchetting while large amount of twinning/detwinning was involved.
International capital market and repeated tax competition
Authors: Kasamatsu Satoshi , Ogawa Hikaru 
Published: November 2019

AbstractWe propose an infinitely repeated game of tax competition with an endogenous capital supply. Our results show that the larger the capital supply elasticity to interest rates, the easier it is for interregional tax coordination within a country to be achieved. The capital supply elasticity is lower when countries are less integrated into the international capital market, and vice versa. Thus, our finding suggests that the regions in the country with a lower (higher) degree of integration in the global market are less (more) likely to achieve tax coordination.