bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catheter-related bloodstream infections in palliative care patients receiving parenteral nutrition by medical home care
Authors: Schedin Anna , Goodrose-Flores Charlotte , Bonn Stephanie , Björkhem-Bergman Linda 
Published: September 2020

BackgroundCatheter-related bloodstream infections (CRBSIs) constitute a major complication associated with the use of central venous lines (CVL). The aim of this study was to investigate the incidence proportion and risk factors of CRSBI in palliative care patients with CVL receiving home parenteral nutrition (HPN).MethodsMedical records from patients admitted to a medical home care unit in stockholm, Sweden, during 2017 were reviewed (n=1022) and 454 palliative care patients with a CVL were identified. Data on CRBSI cases, HPN exposure time, type of parenteral nutrition (PN), age, diagnosis and type of CVL were collected.ResultsTwenty-nine of 143 patients receiving HPN through a CVL were diagnosed with a CRBSI (20%). Nine of 311 patients with CVL without exposure for HPN developed CRBSI (3%). The risk of a CRBSI was significantly higher in patients receiving HPN compared with those not receiving HPN, OR 8.5 (95% CI 4.0 to 18.7). For those receiving HPN six to seven times a week the risk was even higher, OR 13 (95% CI 5.1 to 30.3). The highest incidence proportion of CRBSI (31%) was found in a home care team where patients had been trained to disconnect themselves from the PN drip. Sex, cancer versus non-cancer, type of CVL or protein content in the PN, did not differ between patients that developed CRBSI versus those that did not develop the outcome.ConclusionHPN entails a high risk of CRBSI. A high frequency of PN and incautious handling of the disconnection of the drip, seem to be the most important risk factors.
Prior ingestion of a ketone monoester supplement reduces postprandial glycemic responses in young healthy-weight individuals
Authors: Greaves Grant , Xiang Richard , Rafiei Hossein , Malas Adeeb , Little Jonathan P. 
Published: September 2020

The main objective of this study was to determine whether acute ingestion of a ketone monoester (KME) supplement impacted mixed-meal tolerance test (MMTT) glucose area under the curve (AUC). Nineteen healthy young volunteers (10 males/9 females; age, 24.7 ± 4.9 years; body mass index, 22.7 ± 2.4 kg/m2) participated in a double-blind, placebo-controlled crossover study. Following overnight fasting (≥10 h), participants consumed 0.45 mL/kg of a KME supplement or taste-matched placebo followed by an MMTT 15 min later. Blood samples were collected every 15–30 min over 2.5 h. KME supplementation acutely raised β-hydroxybutyrate AUC (590%, P < 0.0001, d = 2.4) and resulted in decreases in blood glucose AUC (−9.4%, P = 0.03, d = 0.56) and nonesterified fatty acid (NEFA) AUC (−27.3%, P = 0.023, d = 0.68) compared with placebo. No differences were found for plasma insulin AUC (P = 0.70) or gastric emptying estimated by co-ingested acetaminophen AUC (P = 0.96) between ketone and placebo. Overall, results indicate that KME supplementation attenuates postprandial glycemic and NEFA responses when taken 15 min prior to a mixed meal in young healthy individuals. Future studies are warranted to investigate whether KME supplementation may benefit individuals with impaired glycemic control. Novelty: Acute ketone monoester supplementation 15 min prior to a mixed meal decreased postprandial glucose and NEFA levels without significantly impacting postprandial insulin or estimates of gastric emptying. Glucose- and NEFA-lowering effects of ketone monoester supplementation are apparently not mediated by changes in insulin release or gastric emptying.
Combining neutrino experimental light-curves for pointing to the next galactic core-collapse supernova
Authors: Coleiro A. , Molla M. Colomer , Dornic D. , Lincetto M. , Kulikovskiy V. 
Published: September 2020

AbstractThe multi-messenger observation of the next galactic core-collapse supernova will shed light on the different physical processes involved in these energetic explosions. Good timing and pointing capabilities of neutrino detectors would help in the search for an electromagnetic or gravitational-wave counterparts. An approach for the determination of the arrival time delay of the neutrino signal at different experiments using a direct detected neutrino light-curve matching is discussed. A simplified supernova model and detector simulation are used for its application. The arrival time delay and its uncertainty between two neutrino detectors are estimated with chi-square and cross-correlation methods. The direct comparison of the detected light-curves offers the advantage to be model-independent. Millisecond time resolution on the arrival time delay at two different detectors is needed. Using the computed time delay between different combinations of currently operational and future detectors, a triangulation method is used to infer the supernova localisation in the sky. The combination of IceCube, Hyper-Kamiokande, JUNO and KM3NeT/ARCA provides a 90% confidence area of$$140\pm 20\,\hbox {deg}^2$$140±20deg2. These low-latency analysis methods can be implemented in the SNEWS alert system.
Structural, mechanical and thermodynamic properties study on Mg–Y alloys from first-principles calculations
Authors: Chen Yingying , Dou Xilong , Zhu Wenjie , Jiang Gang , Mao Aijie 
Published: September 2020

The structures with different compositions of the binary Mg–Y alloys have been predicted by first-principles calculations combined with an unbiased Crystal structure Analysis by Particle Swarm Optimization (CALYPSO) structure searching method. The two already known stoichiometries alloys of Mg1Y1 with Pm-[Formula: see text] symmetry and Mg3Y1 with Fm-[Formula: see text] are confirmed, and a new stoichiometry alloy of Mg1Y3 with [Formula: see text] symmetry is proposed. The dynamical and mechanical stabilities for the three alloys at different pressures are investigated by phonon spectra and mechanical stability criteria, respectively. Subsequently, the bulk modulus, shear modulus, Young’s modulus, the brittleness/ductile behavior, the elastic anisotropy as well as Vickers hardness for the three alloys at 0 GPa are discussed in detail. The results show that the Mg1Y1, Mg3Y1 and Mg1Y3 alloys improve the hardness and stiffness compared with pure Mg, and Mg1Y3 alloy is of the best ductility in the three alloys. Meanwhile, the three alloys exhibit anisotropic. Moreover, the thermodynamic properties, such as Debye temperature, heat capacity at constant volume, entropy and Helmholtz free energy for the three stable alloys, are predicted and discussed.
Integration of Manufacturing Information via Dynamic Information Model Aggregation
Authors: Schmied Sebastian , Grossmann Daniel , Mathias Selvine G. , Mueller Ralph Klaus 
Published: September 2020

An important part of the industry 4.0 concept is the horizontal and vertical integration of manufacturing systems. Information exchange in traditional production environments happens through interfaces that are connections between strictly defined senders and receivers. This limits the possibility for changing and extending the manufacturing system. A possible approach to enable the information exchange between all system entities uniformly are information models. Such models are semantic descriptions of the available data. The creation of these models needs to follow the manufacturing process, but also requires certain standardization to improve efficiency. Another challenge is the actual technical integration of the information into a common address space. This paper connects an approach for information modeling with a concept for dynamic aggregation. The approach is described with the help of a continuous example that uses OPC UA as a middleware technology.
A new flesh fly species of Oxysarcodexia Townsend from the Brazilian Atlantic Forest and redescription of Oxysarcodexia xon (Dodge, 1968)
Authors: Menezes Marco Antônio , Santos Josenilson Rodrigues dos , Mello-Patiu Cátia Antunes de 
Published: September 2020

A new Neotropical species of Oxysarcodexia Townsend (Diptera, Sarcophagidae) from Atlantic Forest of southeastern Brazil, Oxysarcodexia digitata sp. nov., is described and illustrated based on male and female specimens. This new species resembles O. fraterna Lopes, O. nitida Soares & Mello-Patiu, O. notata Soares & Mello-Patiu, O. vittata (Walker), and O. xon (Dodge), but can be distinguished based on differences in phallic elements. Additionally, the male of Oxysarcodexia xon (Dodge, 1968) is redescribed and illustrated, its female is described for the first time, and new records is presented.
Free Thiol β2-GPI (β-2-Glycoprotein-I) Provides a Link Between Inflammation and Oxidative Stress in Atherosclerotic Coronary Artery Disease
Authors: Weaver James C. , Ullah Inaam , Qi Miao , Giannakopoulos Bill , Rye Kerry Anne , Kockx Maaike , Kritharides Leonard , Krilis Steven A. 
Published: September 2020

Objective:
Atherosclerotic coronary artery disease is well recognised as an inflammatory disorder that is also influenced by oxidative stress. β2-GPI (β-2-glycoprotein-I) is a circulating plasma protein that undergoes post-translational modification and exists in free thiol as well as oxidized forms. The aim of this study was to assess the association between these 2 post-translational redox forms of β2-GPI and atherosclerotic coronary artery disease.

Approach and Results:
Stable patients presenting for elective coronary angiography or CT coronary angiography were prospectively recruited. A separate group of patients after reperfused ST-segment–elevation myocardial infarction formed an acute coronary syndrome subgroup. All patients had collection of fasting serum and plasma for quantification of total and free thiol β2-GPI. Coronary artery disease extent was quantified by the Syntax and Gensini scores. A total of 552 patients with stable disease and 44 with acute coronary syndrome were recruited. While total β2-GPI was not associated with stable coronary artery disease, a higher free thiol β2-GPI was associated with its presence and extent. This finding remained significant after correcting for confounding variables, and free thiol β2-GPI was a better predictor of stable coronary artery disease than hs-CRP (high-sensitivity C-reactive protein). Paradoxically, there were lower levels of free thiol β2-GPI after ST-segment–elevation myocardial infarction.

Conclusions:
Free thiol β2-GPI is a predictor of coronary artery disease presence and extent in stable patients. Free thiol β2-GPI was a better predictor than high-sensitivity C-reactive protein.
Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells
Authors: Liu Oscar Hsin-Fu , Kiema Miika , Beter Mustafa , Ylä-Herttuala Seppo , Laakkonen Johanna P. , Kaikkonen Minna U. 
Published: September 2020

Objective:
Previous studies have demonstrated that the expression of several lysine (K)-specific demethylases (KDMs) is induced by hypoxia. Here, we sought to investigate the exact mechanisms underlying this regulation and its functional implications for endothelial cell function, such as angiogenesis.

Approach and Results:

We analyzed the expression changes of KDMs under hypoxia and modulation of HIF (hypoxia-inducible factor) expression using GRO-Seq and RNA-Seq in endothelial cells. We provide evidence that the majority of the KDMs are induced at the level of nascent transcription mediated by the action of HIF-1α and HIF-2α. Importantly, we show that transcriptional changes at the level of initiation represent the major mechanism of gene activation. To delineate the epigenetic effects of hypoxia and HIF activation in normoxia, we analyzed the genome-wide changes of H3K27me3 using chromosome immunoprecipitation-Seq. We discovered a redistribution of H3K27me3 at ≈2000 to 3000 transcriptionally active loci nearby genes implicated in angiogenesis. Among these, we demonstrate that vascular endothelial growth factor A (
VEGFA
) expression is partly induced by KDM4B- and KDM6B-mediated demethylation of nearby regions. Knockdown of KDM4B and KDM6B decreased cell proliferation, tube formation, and endothelial sprouting while affecting hundreds of genes associated with angiogenesis. These findings provide novel insights into the regulation of KDMs by hypoxia and the epigenetic regulation of VEGFA-mediated angiogenesis.

Conclusions:
Our study describes an additional level of epigenetic regulation where hypoxia induces redistribution of H3K27me3 around genes implicated in proliferation and angiogenesis. More specifically, we demonstrate that KDM4B and KDM6B play a key role in modulating the expression of the major angiogenic driver VEGFA.
Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells
Authors: Grim Joseph C. , Aguado Brian A. , Vogt Brandon J. , Batan Dilara , Andrichik Cassidy L. , Schroeder Megan E. , Gonzalez-Rodriguez Andrea , Yavitt F. Max , Weiss Robert M. , Anseth Kristi S. 
Published: September 2020

Objective:
Resident valvular interstitial cells (VICs) activate to myofibroblasts during aortic valve stenosis progression, which further promotes fibrosis or even differentiate into osteoblast-like cells that can lead to calcification of valve tissue. Inflammation is a hallmark of aortic valve stenosis, so we aimed to determine proinflammatory cytokines secreted from M1 macrophages that give rise to a transient VIC phenotype that leads to calcification of valve tissue.

Approach and Results:
We designed hydrogel biomaterials as valve extracellular matrix mimics enabling the culture of VICs in either their quiescent fibroblast or activated myofibroblast phenotype in response to the local matrix stiffness. When VIC fibroblasts and myofibroblasts were treated with conditioned media from THP-1-derived M1 macrophages, we observed robust reduction of αSMA (alpha smooth muscle actin) expression, reduced stress fiber formation, and increased proliferation, suggesting a potent antifibrotic effect. We further identified TNF (tumor necrosis factor)-α and IL (interleukin)-1β as 2 cytokines in M1 media that cause the observed antifibrotic effect. After 7 days of culture in M1 conditioned media, VICs began differentiating into osteoblast-like cells, as measured by increased expression of RUNX2 (runt-related transcription factor 2) and osteopontin. We also identified and validated IL-6 as a critical mediator of the observed pro-osteogenic effect.

Conclusions:
Proinflammatory cytokines in M1 conditioned media inhibit myofibroblast activation in VICs (eg, TNF-α and IL-1β) and promote their osteogenic differentiation (eg, IL-6). Together, our work suggests inflammatory M1 macrophages may drive a myofibroblast-to-osteogenic intermediate VIC phenotype, which may mediate the switch from fibrosis to calcification during aortic valve stenosis progression.
Smoking Causes Fatal Subarachnoid Hemorrhage
Authors: Rautalin Ilari , Korja Miikka , Kaprio Jaakko 
Published: September 2020

Background and Purpose:
One of the largest twin studies to date suggested that subarachnoid hemorrhage (SAH) is mainly of nongenetic origin, but the causal effect of environmental factors on SAH is yet unknown. We hypothesized that if only one of the twins experience fatal SAH, they do not share the most important environmental risk factor for SAH, namely smoking. If true, such finding would suggest that smoking causes SAH.

Methods:
Through the nationwide cause-of-death register, we followed 16 282 same-sex twin pairs of Finnish origin from the older Finnish Twin Cohort between 1976 and 2018 and identified all participants who died from SAH. For the baseline, we collected risk factor information about smoking, hypertension, physical activity, body mass index, alcohol consumption, and education. We classified the pairs as monozygotic, dizygotic, or of unknown zygosity. We examined the within-pair risk factor differences in the pairs discordant for SAH, that is, where one twin died from SAH and the other did not. We computed both individual (whole cohort) and pairwise (discordant pair) hazard ratios and 95% CIs.

Results:
During the 869 469 person-years of follow-up, we identified 116 discordant and 2 concordant (both died from SAH) twin pairs for fatal SAH. Overall, 25 of the discordant twin pairs were monozygotic. For the whole cohort, smoking (occasional/current) was associated with increased risk of SAH death (hazard ratio, 3.33 [CI, 2.24–4.95]) as compared with nonsmokers (never/former). In the pairwise analyses for discordant twin pairs, we found that the twin who smoked had an increased risk of fatal SAH (hazard ratio, 6.33 [CI, 1.87–21.4]) as compared with the nonsmoking twin. The association remained consistent regardless of the twin pairs’ zygosity or sex.

Conclusions:
Our results provide strong evidence for a causal, rather than associative, role of smoking in SAH.
Skill and Potential Economic Value of Forecasts of Ice Accretion on Wind Turbines
Authors: Strauss Lukas , Serafin Stefano , Dorninger Manfred 
Published: September 2020

AbstractIn this paper, a verification study of the skill and potential economic value of forecasts of ice accretion on wind turbines is presented. The phase of active ice formation on turbine blades has been associated with the strongest wind power production losses in cold climates; however, skillful icing forecasts could permit taking protective measures using anti-icing systems. Coarse- and high-resolution forecasts for the range up to day 3 from global (IFS and GFS) and limited-area (WRF) models are coupled to the Makkonen icing model. Surface and upper-air observations and icing measurements at turbine hub height at two wind farms in central Europe are used for model verification over two winters. Two case studies contrasting a correct and an incorrect forecast highlight the difficulty of correctly predicting individual icing events. A meaningful assessment of model skill is possible only after bias correction of icing-related parameters and selection of model-dependent optimal thresholds for ice growth rate. The skill of bias-corrected forecasts of freezing and humid conditions is virtually identical for all models. Hourly forecasts of active ice accretion generally show limited skill; however, results strongly suggest the superiority of high-resolution WRF forecasts relative to other model variants. Predictions of the occurrence of icing within a period of 6 h are found to have substantially better accuracy. Probabilistic forecasts of icing that are based on gridpoint neighborhood ensembles show slightly higher potential economic value than forecasts that are based on individual gridpoint values, in particular at low cost-loss ratios, that is, when anti-icing measures are comparatively inexpensive.
Comparison of transradial coronary intervention for left main bifurcation disease using the new Braidin® slender 7 Fr sheath and a standard 6 Fr sheath
Authors: Xu Yingkai , Li Yingkai , Yu Jiancai , Wang Deguang , Zhao Qi , Cheng Yujing , Zhou Yujie 
Published: September 2020

Objectives To compare the effectiveness and safety of the Braidin® slender 7 Fr sheath with a standard 6 Fr sheath for treating left main bifurcation disease. Methods From January 2017 to March 2019, 277 patients with left main bifurcation disease who underwent the transradial approach for percutaneous coronary intervention were divided into the slender 7 Fr sheath group (Braidin® slender 7 Fr sheath, n = 154) and standard 6 Fr sheath group (n = 123). Pathological features, surgical effect, and complications were evaluated. Results The rate of using the classic crush technique was significantly higher in the slender 7 Fr sheath group than in the standard 6 Fr sheath group. The slender 7 Fr sheath group had a significantly shorter operation time than the standard 6 Fr sheath group. There were no significant differences in the radial artery occlusion rate after surgery and at 1 month of follow-up between the groups. Multivariate logistic regression analysis showed that 6 Fr and Braidin slender 7 Fr sheaths did not predict radial artery occlusion. Conclusion The Braidin slender 7 Fr sheath has a superior operative process and similar safety for the radial artery as that of the standard 6 Fr sheath for treating left main bifurcation disease.
Long-Term Inhalative Sedation in Children With Pulmonary Diseases
Authors: Meyburg Jochen , Frommhold David , Motsch Johann , Kuss Navina 
Published: September 2020

Objectives: To describe safety and feasibility of long-term inhalative sedation (LTIS) in children with severe respiratory diseases compared to patients with normal lung function with respect to recent studies that showed beneficial effects in adult patients with acute respiratory distress syndrome (ARDS). Design: Single-center retrospective study. Setting: 12-bed pediatric intensive care unit (PICU) in a tertiary-care academic medical center in Germany. Patients: All patients treated in our PICU with LTIS using the AnaConDa® device between July 2011 and July 2019. Measurements and Main Results: Thirty-seven courses of LTIS in 29 patients were analyzed. LTIS was feasible in both groups, but concomitant intravenous sedatives could be reduced more rapidly in children with lung diseases. Cardiocirculatory depression requiring vasopressors was observed in all patients. However, severe side effects only rarely occured. Conclusions: In this largest cohort of children treated with LTIS reported so far, LTIS was feasible even in children with severely impaired lung function. From our data, a prospective trial on the use of LTIS in children with ARDS seems justified. However, a thorough monitoring of cardiocirculatory side effects is mandatory.
A novel microRNA-based signature predicts prognosis among nasopharyngeal cancer patients
Authors: Wang Tianyu , Wu Jian , Wu Yun , Cheng Yin , Deng Yue , Liao Jianchun , Liu Huanhai , Peng Hu 
Published: September 2020

Nasopharyngeal cancer is one of the most common malignant tumors in the head and neck. Identification of promising miRNA biomarkers might benefit a lot to the detection of nasopharyngeal carcinoma. miRNA expression profile and clinical information were obtained from two microarray profiling data sets from the Gene Expression Omnibus (GEO) database. miRNA signature model was constructed via univariate Cox survival analysis, multivariate Cox survival analysis, and least absolute shrinkage and selection operator Cox regression analysis. Kaplan–Meier curve, area under the curve (AUC), decision curve analysis, Box plot, and nomogram were used to evaluate the prognosis of the model to patients. 67 up-regulated and 93 down-regulated miRNAs were identified from GEO microarray data sets ( P < 0.05). A three-miRNA signature (has-miR-142-3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients ( P  < 0.001). The AUCs for the signature were 0.74, 0.7 for the training set and external validation set. The AUC of disease free survival and distant metastasis-free survival were also high. The model has better clinical independence and has better clinical prediction effect when combined with clinical characteristics ( P < 0.0001). Compared with the published models, our model had a higher AUC. Our results revealed that a three-miRNA signature was a potential novel prognostic biomarker for nasopharyngeal carcinoma. Impact statement Nasopharyngeal cancer is one of the most common malignant tumors in the head and neck. Identification of promising miRNA biomarkers might benefit a lot to the detection of nasopharyngeal carcinoma. A three-miRNA signature (has-miR-142-3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients. The model has better clinical independence and has better clinical prediction effect when combined with clinical characteristics. Our results revealed that a three-miRNA signature was a potential novel prognostic biomarker for nasopharyngeal carcinoma.