bluuebunny/crossref_metadata_2025_split huggingface dataset:
Space use and habitat selection of an invasive mesopredator and sympatric, native apex predator
Authors: Wysong Michael L. , Hradsky Bronwyn A. , Iacona Gwenllian D. , Valentine Leonie E. , Morris Keith , Ritchie Euan G. 
Published: May 2020

Abstract
Background
Where mesopredators co-exist with dominant apex predators, an understanding of the factors that influence their habitat and space use can provide insights that help guide wildlife conservation and pest management actions. A predator’s habitat use is defined by its home range, which is influenced by its selection or avoidance of habitat features and intra- and inter-specific interactions within the landscape. These are driven by both innate and learned behaviour, operating at different spatial scales. We examined the seasonal home ranges and habitat selection of actively-managed populations of a native apex predator (dingo Canis dingo) and invasive mesopredator (feral cat Felis catus) in semi-arid Western Australia to better understanding their sympatric landscape use, potential interactions, and to help guide their management.

Methods
We used kernel density estimates to characterise the seasonal space use of dingoes and feral cats, investigate inter- and intra-species variation in their home range extent and composition, and examine second-order habitat selection for each predator. Further, we used discrete choice modelling and step selection functions to examine the difference in third-order habitat selection across several habitat features.

Results
The seasonal home ranges of dingoes were on average 19.5 times larger than feral cats. Feral cat seasonal home ranges typically included a larger proportion of grasslands than expected relative to availability in the study site, indicating second-order habitat selection for grasslands. In their fine-scale movements (third-order habitat selection), both predators selected for roads, hydrological features (seasonal intermittent streams, seasonal lakes and wetlands), and high vegetation cover. Dingoes also selected strongly for open woodlands, whereas feral cats used open woodlands and grasslands in proportion to availability.

Management recommendations
Based on these results, and in order to avoid unintended negative ecological consequences (e.g. mesopredator release) that may stem from non-selective predator management, we recommend that feral cat control focuses on techniques such as trapping and shooting that are specific to feral cats in areas where they overlap with apex predators (dingoes), and more general techniques such as poison baiting where they are segregated.
Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage–related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial
Authors: Sadan Ofer , Singbartl Kai , Kraft Jacqueline , Plancher Joao McONeil , Greven Alexander C. M. , Kandiah Prem , Pimentel Cederic , Hall C. L. , Papangelou Alexander , Asbury William H. , Hanfelt John J. , Samuels Owen 
Published: May 2020

Abstract
Background
Recent reports have demonstrated that among patients with subarachnoid hemorrhage (SAH) treated with hypertonic NaCl, resultant hyperchloremia has been associated with the development of acute kidney injury (AKI). We report a trial comparing the effect of two hypertonic solutions with different chloride contents on the resultant serum chloride concentrations in SAH patients, with a primary outcome aimed at limiting chloride elevation.

Methods
A low ChloridE hyperTonic solution for brain Edema (ACETatE) trial is a single-center, double-blinded, double-dummy, randomized pilot trial comparing bolus infusions of 23.4% NaCl and 16.4% NaCl/Na-acetate for the treatment of cerebral edema in patients with SAH. Randomization occurred when patients developed hyperchloremia (serum Cl− ≥ 109 mmol/L) and required hyperosmolar treatment.

Results
We enrolled 59 patients, of which 32 developed hyperchloremia and required hyperosmolar treatment. 15 patients were randomized to the 23.4% NaCl group, and 17 patients were randomized to the 16.4% NaCl/Na-acetate group. Although serum chloride levels increased similarly in both groups, the NaCl/Acetate group showed a significantly lower Cl− load at the end of the study period (978mEq vs. 2,464mEq, p < 0.01). Secondary outcome analysis revealed a reduced rate of AKI in the Na-acetate group (53.3% in the NaCl group vs. 11.8% in the Na-acetate group, p = 0.01). Both solutions had similar effects on ICP reduction, but NaCl/Acetate treatment had a more prominent effect on immediate post-infusion Na+ concentrations (increase of 2.2 ± 2.8 vs. 1.4 ± 2.6, (p < 0.01)). Proximal tubule renal biomarkers differed in concentration between the two groups.

Conclusions
Our pilot trial showed the feasibility and safety of replacing 23.4% NaCl infusions with 16.4% NaCl/Na-acetate infusions to treat cerebral edema in patients with SAH. The degree of hyperchloremia was similar in the two groups. 16.4% NaCl/Na-acetate infusions led to lower Cl− load and AKI rates than 23.4% NaCl infusions. Further multi-center studies are needed to corroborate these results.

Trial registration
clinicaltrials.gov # NCT03204955, registered on 6/28/2017
Nanosheet composed of gold nanoparticle/graphene/epoxy resin based on ultrasonic fabrication for flexible dopamine biosensor using surface-enhanced Raman spectroscopy
Authors: Hussein Mahmoud A. , El-Said Waleed A. , Abu-Zied Bahaa M. , Choi Jeong-Woo 
Published: May 2020

AbstractConstruction of a fast, easy and sensitive neurotransmitters-based sensor could provide a promising way for the diagnosis of neurological diseases, leading to the discovery of more effective treatment methods. The current work is directed to develop for the first time a flexible Surface-Enhanced Raman Spectroscopy (SERS) based neurotransmitters sensor by using the ultrasonic-assisted fabrication of a new set of epoxy resin (EPR) nanocomposites based on graphene nanosheets (GNS) using the casting technique. The perspicuous epoxy resin was reinforced by the variable loading of GNS giving the general formula GNS/EPR1–5. The designed products have been fabricated in situ while the perspicuous epoxy resin was formed. The expected nanocomposites have been fabricated using 3%, 5%, 10%, 15% and 20% GNS loading was applied for such fabrication process. The chemical, physical and morphological properties of the prepared nanocomposites were investigated by using Fourier transforms infrared spectroscopy, X-ray diffraction, Thermogravimetric analysis, Differential Thermal gravimetry, and field emission scanning electron microscopy methods. The GNS/EPR1–5 nanocomposites were decorated with a layer of gold nanoparticles (Au NPs/GNS/EPR) to create surface-enhanced Raman scattering hot points. The wettability of the Au NPs/GNS/EPR was investigated in comparison with the different nanocomposites and the bare epoxy. Au NPs/GNS/EPR was used as a SERS-active surface for detecting different concentrations of dopamine with a limit of detection of 3.3 µM. Our sensor showed the capability to detect low concentrations of dopamine either in a buffer system or in human serum as a real sample.
A case of reactive lymphoid hyperplasia of the liver in a patient with autoimmune hepatitis
Authors: Kanno Hiroki , Sakai Hisamune , Hisaka Toru , Kojima Satoki , Midorikawa Ryuta , Fukutomi Shogo , Nomura Yoriko , Goto Yuichi , Sato Toshihiro , Yoshitomi Munehiro , Kawahara Ryuichi , Okuda Koji 
Published: May 2020

AbstractBackgroundReactive lymphoid hyperplasia (RLH) of the liver is a benign disorder. It is usually observed in the skin, orbit, thyroid, lung, breast, or gastrointestinal tract, but rarely in the liver. Since the first report of RLH of the liver in 1981, only 75 cases have been described in the past literature. Herein, we report a case of RLH of the liver in a patient with autoimmune hepatitis (AIH), which was misdiagnosed as hepatocellular carcinoma (HCC) preoperatively and resected laparoscopically.Case presentationA 43-year-old Japanese woman with autoimmune hepatitis was followed up for 5 years. During her medical checkup, a hypoechoic nodule in segment 6 of the liver was detected. The nodule had been gradually increasing in size for 4 years. Abdominal ultrasound (US) revealed a round, hypoechoic nodule, 12 mm in diameter. Contrast-enhanced computed tomography (CT) demonstrated that the nodule was slightly enhanced in the arterial dominant phase, followed by perinodular enhancement in the portal and late phases. A magnetic resonance imaging (MRI) scan showed low signal intensity on the T1-weighted image (T1WI) and slightly high signal intensity on the T2-weighted image (T2WI). The findings of the Gd-EOB-DTPA-enhanced MRI were similar to those of contrast-enhanced CT. Tumor markers were all within the normal range. The preoperative diagnosis was HCC and a laparoscopic right posterior sectionectomy was performed. Pathological examination revealed that the nodular lesion was infiltrated by small lymphocytes and plasma cells, and germinal centers were present. Immunohistochemistry was positive for B celland T cell markers, indicating polyclonality.The final diagnosis was RLH of the liver.ConclusionsThe pathogenesis of RLH of the liver remains unknown, and a definitive diagnosis based on imaging findings is extremely difficult. If a small, solitary nodule is found in female patients with AIH, the possibility of RLH of the liver should be considered.
Signs, meanings and practices of people living with human t-cell lymphotropic virus type 1 or tropical spastic myelopathy
Authors: Santana Genildes Oliveira , Libório Ana Mary , Galvão Ana Verena , Pondé Milena Pereira , Sá Katia Nunes 
Published: May 2020

AbstractBackgroundHuman T-cell lymphotropic virus type 1 (HTLV-1) spreads silently in the world’s population and causes several syndromes. Among these, HTLV-1 associated myelopathy, also called tropical spastic paraparesis (HAM/TSP), affects the nervous system. It causes sensorimotor losses, spasticity, muscle weakness, voiding and sexual dysfunction, pain, and balance disorders. There is limited knowledge of the feelings, experiences, and coping mechanisms associated with this neglected disease. The objective of the present qualitative study was to investigate the signs, meanings, and practices of people with HAM/TSP, through narratives obtained from focus groups and individual semi-structured face-to-face interviews.ResultsThirty-eight individuals diagnosed with HAM/TSP participated in the study. The following categories and subcategories emerged from the participants: Signs—physical signs, symptoms, and discovery of the disease; Meanings—reaction to diagnosis and knowledge of disease, fears, and expectations; Practices—daily life, leisure, religious, and treatment activities.ConclusionsPeople with HAM/TSP suffer from symptoms that limit their social participation, and they are affected by complex and multidimensional feelings. This awareness can contribute to the implementation of public policies—focused on the real perspective of these patients—that provide more directed, empathic, and harmonious care for these individuals.
General-type proximal point algorithm for solving inclusion and fixed point problems with composite operators
Authors: Sow T. M. M. 
Published: May 2020

AbstractThe main purpose of this paper is to introduce a new general-type proximal point algorithm for finding a common element of the set of solutions of monotone inclusion problem, the set of minimizers of a convex function, and the set of solutions of fixed point problem with composite operators: the composition of quasi-nonexpansive and firmly nonexpansive mappings in real Hilbert spaces. We prove that the sequence xn which is generated by the proposed iterative algorithm converges strongly to a common element of the three sets above without commuting assumption on the mappings. Finally, applications of our theorems to find a common solution of some nonlinear problems, namely, composite minimization problems, convex optimization problems, and fixed point problems, are given to validate our new findings.
The prevalence of depression among Iranian infertile couples: an update systematic review and meta-analysis
Authors: Alimohamadi Yousef , Mehri Ahmad , Sepandi Mojtaba , Esmaeilzadeh Firooz , Rashti Roya 
Published: May 2020

Abstract
Background
Depression is a common mental disorder. Infertility can lead to depression. The current systematic review and meta-analysis were conducted to estimate the pooled prevalence of depression among Iranian infertile couples. Seven electronic databases (Google Scholar, MagIran, SID, Science Direct, PubMed, Scopus, Web of Science) were searched, up to August 2019, for relevant published studies. The pooled prevalence of depression also pooled mean of depression score was determined using a random-effects model with a 95% confidence interval (95% CI). All analyses performed using Stata ver11 (Stata Corporation, College Station, TX, USA). The 0.05 was considered a significant level.

The main body
Totally, 230 studies were retrieved and 31 studies included in the meta-analysis. The pooled prevalence of depression among infertile couples was about 35.3% (95 % CI 24.1–46.5), and the prevalence of depression among females and males was 48.7% (95% CI 24.0–73.3) and 9% (95% CI 0% to 23.7%), respectively.

Conclusions
Our findings suggest a high prevalence of depression in infertile couples. The results can highlight an important and growing mental disorder among infertile couples that may be overlooked.
Diffusion-weighted imaging in the evaluation of perianal fistula and abscess
Authors: Mohsen Laila Adel , Osman Nasr Mohamed 
Published: May 2020

Abstract
Background
Perianal fistulas are a common inflammatory condition of the anal canal and perianal tissue. The introduction of MRI in the evaluation of suspected perianal inflammation has greatly improved the surgical outcome of these patients as it allowed the direct visualization of anal sphincters, levator ani muscle, and the extent of the disease in relation to these vital structures. Diffusion-weighted imaging (DWI) has been under extensive research to evaluate whether it adds any value in the setting of perianal inflammation.
The aim of our study was to evaluate the visibility of perianal inflammation on DWI and evaluate the diffusion characteristics of perianal fistulas and abscesses and how accurately can DWI classify perianal disease.

Results
Mean age of patients was 37 ± 8.9 years old. The study included 30 fistulas and 15 abscesses. Seven patients had more than 1 fistula or fistula and abscess. Perianal abscesses were well visualized equally on DWI and T2W images and correctly classified by DWI, when compared to post-contrast images. Perianal fistulas without abscesses, on the other hand, had variable visibility scores. Although the visibility of these fistulas on DWI was generally less than T2W and combined DWI and T2W, yet this did not reach a significant level and it was not significantly different between positive and negative inflammatory groups. Combined DWI and T2W evaluation had the highest performance and accurately classified 97.8 % of perianal fistulas and abscesses, and only 1 case was misclassified (2.3%).

Conclusion
DWI had a good performance in the evaluation of perianal inflammatory disease. However, combined DWI and T2W evaluation had better performance which was not significantly different from combined T2W and post-contrast images.
PD-1 Blockade in Anaplastic Thyroid Carcinoma
Authors: Capdevila Jaume , Wirth Lori J. , Ernst Thomas , Ponce Aix Santiago , Lin Chia-Chi , Ramlau Rodryg , Butler Marcus O. , Delord Jean-Pierre , Gelderblom Hans , Ascierto Paolo A. , Fasolo Angelica , Führer Dagmar , Hütter-Krönke Marie Luise , Forde Patrick M. , Wrona Anna , Santoro Armando , Sadow Peter M. , Szpakowski Sebastian , Wu Hongqian , Bostel Geraldine , Faris Jason , Cameron Scott , Varga Andreea , Taylor Matthew 
Published: May 2020

PURPOSE Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always fatal and lacks effective systemic treatment options for patients with BRAF-wild type disease. As part of a phase I/II study in patients with advanced/metastatic solid tumors, patients with anaplastic thyroid carcinoma were treated with spartalizumab, a humanized monoclonal antibody against the programmed death-1 (PD-1) receptor. METHODS We enrolled patients with locally advanced and/or metastatic anaplastic thyroid carcinoma in a phase II cohort of the study. Patients received 400 mg spartalizumab intravenously, once every 4 weeks. The overall response rate was determined according to RECIST v1.1. RESULTS Forty-two patients were enrolled. Adverse events were consistent with those previously observed with PD-1 blockade. Most common treatment-related adverse events were diarrhea (12%), pruritus (12%), fatigue (7%), and pyrexia (7%). The overall response rate was 19%, including three patients with a complete response and five with a partial response. Most patients had baseline tumor biopsies positive for PD-L1 expression (n = 28/40 evaluable), and response rates were higher in PD-L1–positive (8/28; 29%) versus PD-L1–negative (0/12; 0%) patients. The highest rate of response was observed in the subset of patients with PD-L1 ≥ 50% (6/17; 35%). Responses were seen in both BRAF-nonmutant and BRAF-mutant patients and were durable, with a 1-year survival of 52.1% in the PD-L1–positive population. CONCLUSION To our knowledge, this is the first clinical trial to show responsiveness of anaplastic thyroid carcinoma to PD-1 blockade.
Routine Intraoperative Inhaled Milrinone and Iloprost Reduces Inotrope Use in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Pilot Study
Authors: Hu Xiaobo , Li Xiaoqiang , Boggett Stuart , Yang Yang , Chun-Ting Wang , Anstey James , Royse Alistair , Royse Colin 
Published: May 2020

BACKGROUND:
Catecholamine inotropes are frequently used after cardiopulmonary bypass (CPB) but may have undesirable effects. The aim was to identify whether the routine use of inhaled pulmonary vasodilators might reduce the requirement for inotrope drugs after cardiac surgery.

METHODS:
Retrospective cohort study of sequential patients undergoing cardiac surgery at the Royal Melbourne Hospital performed by a single surgeon and anesthesia care team, within 14 months before and after routine implementation of inhaled pulmonary vasodilators, August 2017. Milrinone 4 mg and iloprost 20 µg were inhaled using a vibrating mesh nebulizer (Aerogen) before initiation of CPB and at chest closure. Other aspects of clinical management were unaltered over the time period. Two investigators blinded to each other extracted data from electronic and written medical records. The primary outcome was any use of inotropes in the perioperative period; a Fisher exact test was used to analyze any differences between the 2 groups. Demographic data, hemodynamic data, and use of inotropes and vasopressors were collected from induction of anesthesia to 36 hours postoperative in the intensive care unit (ICU). Hospital and ICU length of stay, cost, and complications were collected.

RESULTS:
Any use of inotropes was significantly lower with inhaled pulmonary dilators (62.5% vs 86.8%, odds ratio [95% confidence interval {CI}], 0.253 (0.083–0.764); P = .011), including intraoperative inotrope use (37.5% vs 86.8%, odds ratio [95% CI], 0.091 (0.03–0.275); P < .001). ICU length of stay was significantly lower with inhaled pulmonary dilators (45 hours, interquartile range [IQR], 27–65 vs 50 hours, IQR, 45–74; P = .026). There were no significant differences among major postoperative complications or costs between groups.

CONCLUSIONS:
Routine use of inhaled milrinone 4 mg and iloprost 20 µg before and after CPB is associated with reduced postoperative inotrope use.
Once upon a dish: engineering multicellular systems
Authors: Haase Kristina , Freedman Benjamin S. 
Published: May 2020

ABSTRACT
In February 2020, the European Molecular Biology Laboratory (EMBL) and the Institute for Bioengineering of Catalonia (IBEC) joined forces to unite researchers from all over the globe to discuss emerging topics in ‘Engineering Multicellular Systems’. As we review here, key themes that arose throughout the meeting included the ethics of organoids in developmental biology, bottom-up versus top-down models, tissue organizing principles, and the future of improving these systems to better mimic the natural world.
Insect wing damage: causes, consequences and compensatory mechanisms
Authors: Rajabi Hamed , Dirks Jan-Henning , Gorb Stanislav N. 
Published: May 2020

ABSTRACT
The evolution of wings has played a key role in the success of insect species, allowing them to diversify to fill many niches. Insect wings are complex multifunctional structures, which not only have to withstand aerodynamic forces but also need to resist excessive stresses caused by accidental collisions. This Commentary provides a summary of the literature on damage-reducing morphological adaptations in wings, covering natural causes of wing collisions, their impact on the structural integrity of wings and associated consequences for both insect flight performance and life expectancy. Data from the literature and our own observations suggest that insects have evolved strategies that (i) reduce the likelihood of wing damage and (ii) allow them to cope with damage when it occurs: damage-related fractures are minimized because wings evolved to be damage tolerant and, in the case of wing damage, insects compensate for the reduced aerodynamic efficiency with dedicated changes in flight kinematics.
Motor Competence, Physical Activity, and Fitness across Early Childhood
Authors: KING-DOWLING SARA , PROUDFOOT NICOLE A. , CAIRNEY JOHN , TIMMONS BRIAN W. 
Published: May 2020

ABSTRACT

Objectives
To examine if the associations between motor competence and physical activity and musculoskeletal fitness change over time, whether motor competence is associated with longitudinal trajectories of physical activity and fitness, and mediating pathways among these constructs across early childhood.

Methods
Four hundred and eighteen children 3 to 5 yr of age (210 boys; age, 4.5 ± 1.0 yr) were recruited and completed three annual assessments as part of the Health Outcomes and Physical activity in Preschoolers study. Motor competence was assessed using the Bruininks–Oseretsky Test of Motor Proficiency Second Edition—Short Form. Musculoskeletal fitness (short-term muscle power) was evaluated using a modified 10-s Wingate protocol on a cycle ergometer. Physical activity was measured over 7 d using accelerometers.

Results
At baseline, the cross-sectional relationship between motor competence and vigorous physical activity was not significant; however, a significant, weak positive association emerged across time. Results from longitudinal mixed-effect models found motor competence to be a significant positive predictor of musculoskeletal fitness and vigorous physical activity and to be associated with steeper increases in physical activity across time. Motor competence was independently associated with musculoskeletal fitness and physical activity during this early childhood period.

Conclusions
Motor competence is an important independent predictor of physical activity and musculoskeletal fitness levels across early childhood. Motor competence may be an important target for early interventions to improve both physical activity and fitness in the early years.