bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid adaptive synchronization protocol for nondeterministic perturbed fractional-order chaotic nonlinear systems
Authors: Lin Funing , Xue Guangming , Su Guangwang , Qin Bin 
Published: April 2020

AbstractIn this paper, we investigate hybrid adaptive synchronization issue for a class of perturbed fractional-order chaotic systems with nondeterministic nonlinear terms. On the basis of fractional-order extended version of Lyapunov stability criterion, a novel fuzzy adaptive synchronization control protocol coupled with backstepping-based method is constructed, ensuring that the synchronization errors converge to a sufficiently small region of the origin. In order to avert the occurrence of “explosion of complexity”, we take advantage of a fuzzy logic system to estimate the unknown systematic term approximately in every backstepping step. Finally, some numerical simulations are given to exemplify the effectiveness of the proposed approach.
Novel method for reduction of virus load in blood plasma by sonication
Authors: Pförringer D. , Braun K. F. , Mühlhofer H. , Schneider J. , Stemberger A. , Seifried E. , Pohlscheidt E. , Seidel M. , Edenharter G. , Duscher D. , Burgkart R. , Obermeier A. 
Published: April 2020

Abstract
Background
Aim of the present study is the evaluation of ultrasound as a physical method for virus inactivation in human plasma products prior to transfusion. Our study is focused on achieving a high level of virus inactivation simultaneously leaving blood products unaltered, measured by the level of degradation of coagulation factors, especially in third world countries where virus contamination of blood products poses a major problem. Virus inactivation plays an important role, especially in the light of newly discovered or unknown viruses, which cannot be safely excluded via prior testing.

Methods
Taking into account the necessary protection of the relevant coagulation activity for plasma, the basis for a sterile virus inactivation under shielding gas insufflation was developed for future practical use. Influence of frequency and power density in the range of soft and hard cavitation on the inactivation of transfusion-relevant model viruses for Hepatitis-(BVDV = bovine diarrhea virus), for Herpes-(SFV = Semliki Forest virus, PRV = pseudorabies virus) and Parvovirus B19 (PPV = porcine parvovirus) were examined. Coagulation activity was examined via standard time parameters to minimize reduction of functionality of coagulation proteins. A fragmentation of coagulation proteins via ultrasound was ruled out via gel electrophoresis. The resulting virus titer was examined using end point titration.

Results
Through CO2 shielding gas insufflation—to avoid radical emergence effects—the coagulation activity was less affected and the time window for virus inactivation substantially widened. In case of the non-lipidated model virus (AdV-luc = luciferase expressing adenoviral vector), the complete destruction of the virus capsid through hard cavitation was proven via scanning electron microscopy (SEM). This can be traced back to microjets and shockwaves occurring in hard cavitation. The degree of inactivation seems to depend on size and compactness of the type of viruses. Using our pre-tested and subsequently chosen process parameters with the exception of the small PPV, all model viruses were successfully inactivated and reduced by up to log 3 factor. For a broad clinical usage, protection of the coagulation activities may require further optimization.

Conclusions
Building upon the information gained, an optimum inactivation can be reached via raising of power density up to 1200 W and simultaneous lowering of frequency down to 27 kHz. In addition, the combination of the two physical methods UV treatment and ultrasound may yield optimum results without the need of substance removal after the procedure.
Biological links between traumatic brain injury and Parkinson’s disease
Authors: Delic Vedad , Beck Kevin D. , Pang Kevin C. H. , Citron Bruce A. 
Published: April 2020

AbstractParkinson’s Disease (PD) is a progressive neurodegenerative disorder with no cure. Clinical presentation is characterized by postural instability, resting tremors, and gait problems that result from progressive loss of A9 dopaminergic neurons in the substantia nigra pars compacta. Traumatic brain injury (TBI) has been implicated as a risk factor for several neurodegenerative diseases, but the strongest evidence is linked to development of PD. Mild TBI (mTBI), is the most common and is defined by minimal, if any, loss of consciousness and the absence of significant observable damage to the brain tissue. mTBI is responsible for a 56% higher risk of developing PD in U.S. Veterans and the risk increases with severity of injury. While the mounting evidence from human studies suggests a link between TBI and PD, fundamental questions as to whether TBI nucleates PD pathology or accelerates PD pathology in vulnerable populations remains unanswered. Several promising lines of research point to inflammation, metabolic dysregulation, and protein accumulation as potential mechanisms through which TBI can initiate or accelerate PD. Amyloid precursor protein (APP), alpha synuclein (α-syn), hyper-phosphorylated Tau, and TAR DNA-binding protein 43 (TDP-43), are some of the most frequently reported proteins upregulated following a TBI and are also closely linked to PD. Recently, upregulation of Leucine Rich Repeat Kinase 2 (LRRK2), has been found in the brain of mice following a TBI. Subset of Rab proteins were identified as biological substrates of LRRK2, a protein also extensively linked to late onset PD. Inhibition of LRRK2 was found to be neuroprotective in PD and TBI models. The goal of this review is to survey current literature concerning the mechanistic overlap between TBI and PD with a particular focus on inflammation, metabolic dysregulation, and aforementioned proteins. This review will also cover the application of rodent TBI models to further our understanding of the relationship between TBI and PD.
Long-term survival after repeated resection for lung metastasis originating from pancreatic cancer: a case report
Authors: Uesato Yasunori , Tamashiro Koichi , Takatsuki Mitsuhisa 
Published: April 2020

Abstract
Background
Pancreatic cancer has a grave prognosis. Most patients with metastatic pancreatic cancer are inoperable, and case reports of resection of lung metastasis from pancreatic cancer are rare. This patient underwent resection of a lung metastasis twice after pancreaticoduodenectomy for pancreatic cancer.

Case presentation
A 75-year-old man with pancreaticoduodenectomy and adjuvant chemotherapy for pancreatic cancer was diagnosed with a lung metastasis 48 months after surgery. Histological findings after thoracoscopic partial resection of the right lung by video-assisted thoracic surgery confirmed the presence of a lung metastasis originating from the pancreatic cancer. The patient refused chemotherapy. A new lung metastasis was detected 84 months following the second surgery (132 months after the pancreaticoduodenectomy). After thoracoscopic partial resection of the left lung by video-assisted thoracic surgery, the histological findings once again confirmed a metastasis that originated from the pancreatic cancer. The patient refused chemotherapy and remained alive and relapse-free after the 10-month follow-up.

Conclusion
Detection and resection of an isolated lung metastasis originating from pancreatic cancer may improve prognosis. Careful follow-up may be warranted to identify patients who might benefit from aggressive local treatment of oligometastasic pancreatic cancer.
Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves’ Disease and Hashimoto’s Hypothyroidism
Authors: Zhang Qian-Yue , Liu Wei , Li Lu , Du Wen-Hua , Zuo Chun-Lin , Ye Xiao-Ping , Zhou Zheng , Yuan Fei-Fei , Ma Yu-Ru , Sun Feng , Yu Sha-Sha , Xie Hui-Jun , Zhang Chang-Run , Ying Ying-Xia , Yuan Guo-Yue , Gao Guan-Qi , Liang Jun , Zhao Shuang-Xia , Song Huai-Dong 
Published: April 2020

Abstract

Context
Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are the 2 main autoimmune thyroid diseases that have both similarities and differences. Determining the genetic basis that distinguishes HT from GD is key for a better understanding of the differences between these closely related diseases.

Objects
To identify the susceptibility genes for HT in the Chinese cohort and compare susceptibility genes between GD and HT.

Design
In the current study, 18 SNPs from 18 established GD risk loci were selected and then genotyped in 2682 patients with HT, 4980 patients with GD, and 3892 controls. The association analysis between HT and controls and heterogeneity analysis between HT and GD were performed on SPSS, with the logistic regression analysis adjusted for sex and age.

Results
We identified 11 susceptibility loci for HT in the Chinese Han population, with 4 loci, including the rs1265883 in SLAMF6 locus, rs1024161 in CTLA4, rs1521 in HLA-B, and rs5912838 in GPR174/ ITM2A at X chromosome, reaching genome-wide significance of 5 × 10–8. Five loci were reported to be associated with HT for the first time. We also identified 6 susceptibility loci with heterogeneity between GD and HT. Out of them, 4 loci were associated with GD but not with HT, including HLA-DPB1, CD40, TSHR, and TG; the association of HLA-B with GD was stronger than that with HT, but the association of SLAMF6 was reversed.

Conclusion
Our findings suggested that the pathogenesis of HT and GD was different.
Pediatric Patient With Ulcerative Colitis-Associated Bronchiectasis
Authors: Russi Abigail , Gurbani Neepa , Rosen Michael J. , Mallon Daniel , LeBlanc Francis R. 
Published: April 2020

ABSTRACT
We report a unique case of ulcerative colitis-associated bronchiectasis in a pediatric patient 6 years after colectomy. The patient presented with a chronic cough and had a computed tomography demonstrating bronchiectasis. She was treated with sputum expectoration (airway clearance) via chest physiotherapy and pulse-dose steroids with a prolonged oral taper. Her initial response was excellent; however, she experienced a recurrence of symptoms with de-escalation of airway clearance. Pulmonary extraintestinal manifestations of inflammatory bowel disease are most often diagnosed later in life. Both the severity of this patient's presentation and her age are unique to this case.
Wahrheit unter dem Vergrößerungsglas. Vorstellungen von Subjekt und Technik in der Rechtsprechung zur Polygraphie
Authors: Fischer Larissa , Paul Bettina , Voigt Torsten H. 
Published: April 2020

Zusammenfassung
Lügendetektion erlebt an deutschen Gerichten eine Konjunktur, obwohl diese Praxis wissenschaftlich umstritten ist und in der höchstrichterlichen Rechtsprechung kritisch gesehen wird. Wir analysieren die deutsche Rechtsprechung und das juristische Schrifttum zwischen 1954 und 2017 und arbeiten darin eine doppelte Verschiebung heraus, die die fortwährende Aushandlung um die Legitimität der Testverfahren erklärt. Erstens verändert sich das Verständnis des Subjekts, welches Gegenstand des Testverfahrens ist. Zweitens wandelt sich die Bewertung der Wissenschaftlichkeit und die Rolle des Apparats sowie des Testverfahrens. Aus wissens- und techniksoziologischer Perspektive zeigen wir, wie das Verhältnis von Technik und Subjekt sowie Körper und Wissen in der Rechtsprechung zur Polygraphie konzeptualisiert wird. Damit leistet der Beitrag Einsichten über die Rolle wissenschaftlicher Expertise im Rechtssystem.
Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision
Authors: Salido Ezequiel M. , Ramamurthy Visvanathan 
Published: April 2020

Photoreceptor neurons are surrounded by an extracellular matrix, called the interphotoreceptor matrix (IPM). Activities crucial to vision occur within the IPM, including trafficking of nutrients and metabolites, retinal attachment, and interactions needed for normal outer segment phagocytosis. The IPM includes the following two unique proteoglycans: IPM proteoglycan 1 (IMPG1) and IMPG2. Patients with mutations in IMPG1/IMPG2 develop visual deficits with subretinal material accumulation, highlighting the critical role of the IPM in vision. To determine the role of these proteoglycans in retinal physiology and the pathologic mechanisms that lead to vision loss, we generated mouse models lacking IMPG1/IMPG2. In normal retina, IMPG1 and IMPG2 occupy distinct IPM compartments, represent the main source of chondroitin sulfate and are fundamental for the constitution of the cone-specific glycocalyx stained by the PNA (peanut agglutinin) lectin marker. No evident morphologic or functional deficits were found in mice lacking IMPG1. In the absence of IMPG2, IMPG1 abnormally accumulated at the subretinal space need, likely leading to the formation of subretinal lesions and reduced visual function. Interestingly, mice lacking both IMPG1 and IMPG2, regardless of sex, showed normal retinal structure and function, demonstrating that the aberrant IMPG1 distribution is the main cause of the visual alterations observed in the absence of IMPG2. In conclusion, our results show the dependence of secreted proteoglycans such as IMPG1 on the extracellular environment to properly integrate into the matrix, demonstrate the role of IMPG2 in shaping the IPM, and shed light on the potential mechanisms leading to the development of subretinal lesions and vision loss.SIGNIFICANCE STATEMENTThe photoreceptors are specialized neurons that drive phototransduction in the mammalian retina. These cells are organized and surrounded by an extracellular matrix, the interphotoreceptor matrix (IPM). Mutations in IPM proteoglycans are associated with blindness in humans. Our studies show that two specific proteoglycans of the IPM, IPM proteoglycan 1 (IMPG1) and IMPG2, form a dynamic structure with distinct localization and dependency. When IMPG2 is absent, IMPG1 cannot integrate into the IPM, leading to abnormal proteoglycan accumulation and visual deficits. This work adds a new layer of understanding to IPM physiology and describes the pathologic events following deficits in proteoglycans, providing novel possibilities for visual restoration in patients with IMPG-related pathologies.
Genomic Structure, Evolutionary Origins, and Reproductive Function of a Large Amplified Intrinsically Disordered Protein-Coding Gene on the X Chromosome (Laidx) in Mice
Authors: Arlt Martin F , Brogley Michele A , Stark-Dykema Evan R , Hu Yueh-Chiang , Mueller Jacob L 
Published: April 2020

Abstract
Mouse sex chromosomes are enriched for co-amplified gene families, present in tens to hundreds of copies. Co-amplification of Slx/Slxl1 on the X chromosome and Sly on the Y chromosome are involved in dose-dependent meiotic drive, however the role of other co-amplified genes remains poorly understood. Here we demonstrate that the co-amplified gene family on the X chromosome, Srsx, along with two additional partial gene annotations, is actually part of a larger transcription unit, which we name Laidx. Laidx is harbored in a 229 kb amplicon that represents the ancestral state as compared to a 525 kb Y-amplicon containing the rearranged Laidy. Laidx contains a 25,011 nucleotide open reading frame, predominantly expressed in round spermatids, predicted to encode an 871 kD protein. Laidx has orthologous copies with the rat and also the 825-MY diverged parasitic Chinese liver fluke, Clonorchis sinensis, the likely result of a horizontal gene transfer of rodent Laidx to an ancestor of the liver fluke. To assess the male reproductive functions of Laidx, we generated mice carrying a multi-megabase deletion of the Laidx-ampliconic region. Laidx-deficient male mice do not show detectable reproductive defects in fertility, fecundity, testis histology, and offspring sex ratio. We speculate that Laidx and Laidy represent a now inactive X vs. Y chromosome conflict that occurred in an ancestor of present day mice.
KARAKTERISTIK RANGKAIAN EKIVALEN DIODA BLEND ORGANIK P3OT : PCBM
Authors: Setya Winda 
Published: April 2020

Has conducted research diode characteristics equivalent circuit of the organic blend P3OT: PCBM. In this study, the blend of P3OT:PCBM was sandwiched between a transparent indium tin oxide (ITO) electrode and an Al backside contact. The current-voltage characteristic of the diode was measured under the dark and illumination. In order to determine the electrical parameters of the diode, we employed an equivalent circuit model developed originally for inorganic diode. As a result, the series resistance decreases while the reverse saturation current density increases by decreasing the thickness of P3OT:PCBM layer. This result may be useful for improving the performance of developing organic diode.
RANCANG BANGUN ALAT PRAKTIKUM GERBANG LOGIKA DASAR BERBASIS OP-AMP
Authors: Syahbani Abdul Karim 
Published: April 2020

Penggunaan teknologi sekarang ini semakin berkembang khususnya dalam elektronika. Dalam ilmu elektronika terdapat suatu komponen yang merupakan gabungan dari komponen elektronika lainnya, komponen tersebut adalah IC (Integrated Circuit). Di dalam IC terdapat suatu rangkaian logika yang disebut gerbang logika. Gerbang (gate) berfungsi untuk menggambarkan hubungan antara masukan dan keluaran. Perancangan alat ini bertujuan untuk mempermudah peserta didik untuk memahami konsep gerbang logika menggunakan alat elektronika yang bernama OP-AMP. Metode yang digunakan adalah dengan melakukan praktikum. Model praktikum yang digunakan adalah inkuiri dimana siswa dituntut untuk mengembangkan ide yang didapatkan dari pembelajaran di kelas. Hasilnya percobaan dapat disimpulkan bahwa gerbang logika dapat membuktikan fungsi dari tabel kebenaran gerbang logika masing-masing gerbang logika mempunyai cara kerja dan karakteristik yang berbeda-beda yaitu; Gerbang logika NOT merupakan pembalik yang berarti output yang dihasilkan merupakan kebalikan dari inputnya, Gerbang logika AND adalah gerbang logika yang memiliki 2 input atau lebih, Gerbang logika OR memiliki 2 atau lebih sinyal input, dan Gerbang logika NOR adalah inverter dari OR. Untuk menentukan gerbang logika sesuai dengan tabel kebenaran ditunjukan dengan nyala lampu pada alat tersebut jika 0 diwakili dengan keluaran lampu mati, sedangkan jika 1 diwakili dengan keluaran lampu hidup.
ANALISIS GERAK JATUH BEBAS DENGAN METODE VIDEO BASED LABORATORY (VBL) MENGGUNAKAN SOFTWARE TRACKER
Authors: Ristiawan Agung 
Published: April 2020

The purpose of this study is to determine the magnitude of the gravitational acceleration in free fall motion analyzed by the Tracker and determine the magnitude of the acceleration of free-falling objects depending on the magnitude of the force affecting the object by varying the distance the object is dropped. Retrieval of data in this study through experiments in Catur Tunggal, Yogyakarta. The subject of this research is the large acceleration of free-falling body motion. In the free fall motion variations in the height of falling objects by 40, 50, 60, 70, 80, 90, and 100 cm for the same mass of objects that is 353 grams. The data needed is the position of the load on the free fall through Tracker analysis conducted on the recorded video. To find out the magnitude of the velocity and the magnitude of the frictional force acting on free fall motion an analysis is performed using a predetermined equation. The effective time in this study is two months. Based on the Tracker analysis, a velocity graph of linear time is obtained, from the graph the acceleration of free falling objects obtained by the equation obtained in the linear graph is Y = mt + b, where m is the gradient of the linear graph showing the acceleration obtained by analyzing Tracker is the same as gravitational acceleration in theory and for free fall motion of objects obtained an average acceleration of (9,63 ± 0,33) m/s2.
Pengembangan Modul Elektronik Fisika Berbasis Konstruktivisme untuk Kelas X SMA
Authors: Maiyena Sri , Imamora Marjoni 
Published: April 2020

Abstractlimitations on the hard module and the lack of availability of technology-based learning media led to a lack of student motivation in learning physics. As a result, it is necessary to develop a constructivism-based electronic physics module. The objective of this research is to know the validity of constructivism-based electronic physics module for 1st student in Senior high school. This research is research and development research. Feasibility tests of the electronic module are carried out through the validation. Validation was carried out by three validators. Based on validation, it showed that constructivism-based electronic physics module that was developed is very valid with a percentage of 89.08%.AbstrakKeterbatasan pada modul cetak serta kurangnya ketersediaan media pembelajaran yang berbasis teknologi menyebabkan kurangnya motivasi siswa dalam mempelajari fisika. Untuk itu perlu dikembangkan sebuah Modul Elektronik fisika berbasis konstruktivisme. Penelitian ini bertujuan untuk menghasilkan Modul Elektronik Fisika yang valid untuk siswa Kelas X SMA. Penelitian ini adalah penelitian pengembangan (research development) dengan menggunakan model 4-D. Pada tahap develop dilakukan pengembangan modul dengan divalidasi oleh 3 orang validator. Berdasarkan hasil validasi terhadap modul elektronik fisika berbasis konstruktivisme yang dikembangkan adalah sangat valid dengan persentase 89,08%.
Effect of Perioperative Antibacterial Prophylaxis Using Eye Drops with Fluoroquinolones on Conjunctival Microflora in Patients before and after Phacoemulsification
Authors: Pirogov Yu. I. , Oblovatskayа E. S. , Shustrova T. A. , Khrоmova Е. S. 
Published: April 2020

Purpose. to evaluate the efficacy of perioperative antibacterial prophylaxis using eye drops with fluoroquinolones with the evaluation of conjunctival microflora structure with its antibiotic resistance.Patients and Methods. The study was carried out using the results of one preoperative and four times postoperative swabs taken from the conjunctival cavity in 50 patients (52 eyes) aged 49 to 91 undergoing phacoemulsification. All the strains were undergoing the 16 antibacterial drugs-panel susceptibility testing including the most common ophthalmic dosage form in the Russian Federation. The antibacterial drugs instillations were used during the postoperative period: levofloxacin in group 1 (30 eyes) and moxifloxacin in group 2 (22 eyes).Results. The structure of conjunctival microflora in the two groups was similar prior to phacoemulsification. In 32 cases (61.5 %) bacterial growth was obtained preoperatively. Among them S. epidermidis strains were detected in 68.8 %, S. aureus strains were detected in 31.2 %. During the use of postoperative antibiotic prophylaxis, the number of positive swabs was constantly decreasing. In 1 hour a qualitative change in the microflora structure was observed. The number of S. aureus strains reduced. The number of S. epidermidis strains increased to 80 %. And previously undetected Corynebacterium spp. strains were found. In 1 day the conjunctival microflora was represented only by S. epidermidis. In 1 week all the swabs were sterile. In 1 month after phacoemulsification, positive swabs were obtained in 7.7 % (mainly S. epidermidis) only in group 1, where levofloxacin instillations were used as the postoperative antibiotic prophylaxis (р < 0,05). Moxifloxacin, gatifloxacin and antiseptic drugs showed the highest in vitro activity against selected strains.Conclusion. The strains of coagulase-negative staphylococcus S. epidermidis prevailed in conjunctival microflora structure. During the use of postoperative antibiotic prophylaxis, the number of positive swabs is progressively reduced to zero by the 7th day in both groups. A more persistent permanent effect of moxifloxacin, maintaining for 1 month after the operation was found in comparing two patients’ groups received fluoroquinolone eye drops to prevent infection after phacoemulsification.