bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of three 3D scanning techniques for paintings, as applied to Vermeer’s ‘Girl with a Pearl Earring’
Authors: Elkhuizen Willemijn S. , Callewaert Tom W. J. , Leonhardt Emilien , Vandivere Abbie , Song Yu , Pont Sylvia C. , Geraedts Jo M. P. , Dik Joris 
Published: November 2019

Abstract
A seventeenth-century canvas painting is usually comprised of varnish and (translucent) paint layers on a substrate. A viewer’s perception of a work of art can be affected by changes in and damages to these layers. Crack formation in the multi-layered stratigraphy of the painting is visible in the surface topology. Furthermore, the impact of mechanical abrasion, (photo)chemical processes and treatments can affect the topography of the surface and thereby its appearance. New technological advancements in non-invasive imaging allow for the documentation and visualisation of a painting’s 3D shape across larger segments or even the complete surface. In this manuscript we compare three 3D scanning techniques, which have been used to capture the surface topology of Girl with a Pearl Earring by Johannes Vermeer (c. 1665): a painting in the collection of the Mauritshuis, the Hague. These three techniques are: multi-scale optical coherence tomography, 3D scanning based on fringe-encoded stereo imaging (at two resolutions), and 3D digital microscopy. Additionally, scans were made of a reference target and compared to 3D data obtained with white-light confocal profilometry. The 3D data sets were aligned using a scale-invariant template matching algorithm, and compared on their ability to visualise topographical details of interest. Also the merits and limitations for the individual imaging techniques are discussed in-depth. We find that the 3D digital microscopy and the multi-scale optical coherence tomography offer the highest measurement accuracy and precision. However, the small field-of-view of these techniques, makes them relatively slow and thereby less viable solutions for capturing larger (areas of) paintings. For Girl with a Pearl Earring we find that the 3D data provides an unparalleled insight into the surface features of this painting, specifically related to ‘moating’ around impasto, the effects of paint consolidation in earlier restoration campaigns and aging, through visualisation of the crack pattern. Furthermore, the data sets provide a starting point for future documentation and monitoring of the surface topology changes over time. These scans were carried out as part of the research project ‘The Girl in the Spotlight’.
Temporal patterns of three sympatric pheasant species in the Nanling Mountains: N-mixture modeling applied to detect abundance
Authors: Zou Fasheng , Zhang Qiang , Zhang Min , Lee Myung-Bok , Wang Xincai , Gong Yuening , Yang Changteng 
Published: November 2019

Abstract

Background
The reliability of long-term population estimates is crucial for conservation and management purposes. Most previous studies assume that count indices are proportionally related to abundance; however, this assumption may not hold when detection varies spatially and temporally. We examined seasonal variations in abundance of three bird species (Cabot’s Tragopan Tragopan caboti, Silver Pheasant Lophura nycthemera, and White-necklaced Partridge Arborophila gingica) along an elevational gradient, using N-mixture models that take into account imperfect detection in our bird data.

Methods
Camera-trapping was used to monitor temporal activity patterns of these species at Guangdong Nanling National Nature Reserve from December 2013 to November 2017 (4 seasons per year). For abundance analysis (N-mixture modeling), we divided a year into 4 seasons, i.e. 3 months per season, and performed the analysis by season. Elevation was incorporated into the N-mixture model as a covariate that may affect abundance. We compared the N-mixture model with a null model (no covariate model) and selected the better model based on AIC values to make an inference.

Results
From 24 sampling sites, we obtained 6786 photographs of 8482 individuals of 44 bird species and 26 mammal species. Silver Pheasant was photographed much more frequently and showed higher temporal activity frequency than White-necklaced Partridge or Cabot’s Tragopan. Silver Pheasant was camera-captured most frequently in summer, and other two species in winters. All three species had two daytime activity peaks: between 6:00 a.m. and 10:00 a.m., and between 5:00 p.m. and 7:00 p.m., respectively. Our estimated abundance and detection probability from the N-mixture model were variable by season. In particular, all three species showed greater abundance in summer than in winter, and estimated abundance patterns of all three species were more similar with observed camera-trapping counts in summers. Moreover, in winter, elevation had a positive impact on abundance of Silver Pheasant and Cabot’s Tragopan, but not on White-necklaced Partridge.

Conclusions
Our results demonstrate that the N-mixture model performed well in the estimation of temporal population abundance at local fixed permanent plots in mountain habitat in southern China, based on the modeling of repeated camera-trapping counts. The seasonal differences in abundance of the three endemic bird species and the strong effect of elevation on abundance of two species in winter were only indicative of variations in spatio-temporal distribution within species and between species. In identifying suitable habitat for endemic pheasants, the positive elevational effect also suggests that more attention should be paid to conservation of areas with higher elevation in the Nanling Mountains.
Prediction of nutritive sucking in preterm babies (<34 weeks) and preterm sucking readiness scale
Authors: Kumari Nisha , Jain Ashish , Ramji Siddarth 
Published: November 2019

Abstract

Objective
To determine predictors of nutritive-sucking in babies < 34 weeks and estimate the appropriate preterm sucking readiness (PTSR) score as an indicator of readiness of nutritive-sucking.

Methods
Prospective longitudinal observational study conducted in Neonatal unit of a referral hospital attached to Medical College. Forty-nine inborn babies of 28-34 weeks’ gestation and on full gavage feeds were enrolled.

Results
(a) Nutritive-sucking was achieved at a median age of 14 days (Range 7–50). (b) Low birth weight (LBW) (< 1531.1 ± 142.8) and lesser gestational age (GA) (< 32.8 ± 1) were poor predictors (p < 0.05) and have a significant independent negative association (Correlation birth weight (BW) - 0.0222, GA − 2.2177) with age at which established nutritive-sucking was achieved. (c) PTSR score of ≥9 had the best prediction for achievement of nutritive-sucking at 14-days of life, with a sensitivity of 92.3% and specificity of 100%.

Conclusion
PTSR score is a sensitive and specific tool to predict the readiness for nutritive-sucking in preterm babies < 34 weeks.
The effect of image quality on the reliability of OCT angiography measurements in patients with diabetes
Authors: Czakó Cecília , István Lilla , Ecsedy Mónika , Récsán Zsuzsa , Sándor Gábor , Benyó Fruzsina , Horváth Hajnalka , Papp András , Resch Miklós , Borbándy Ágnes , Nagy Zoltán Zsolt , Kovács Illés 
Published: November 2019

Abstract

Background
This study aimed to determine the relationship between image quality and measurement repeatability of optical coherence tomography angiography (OCTA) parameters in patients with non-proliferative diabetic retinopathy.

Methods
A total of 100 eyes of 50 patients were included in the study. Three OCTA images were obtained consecutively during one session of imaging in all patients using the RTVue AngioVue OCTA device. We applied the signal strength index (SSI) provided by the RTVue system to define scan quality. Superficial vessel density (VD) in the central 3 × 3 mm macular and in the perifoveal region, as well as foveal avascular zone (FAZ) area were evaluated by the AngioAnalytics software for each scan from three consecutive measurements, whereby measurement repeatability of the OCTA parameters were calculated. The effect of SSI value on OCTA parameters, as well as on measurement errors was assessed.

Results
Values of SSI ranged from 30 to 85 with an overall mean of 61.79 ± 10.38. Mean SSI values showed significant positive correlation with the mean retinal capillary vessel density values, but not with non-flow area. Repeatability of OCTA parameters was generally improved with higher SSI values. We calculated a mean correction factor of 0.22% (95% CI 0.20–0.24 µm; p < 0.001) for VD at the 3 × 3 mm macular scan, 0.23% (95% CI 0.21–0.26%; p < 0.001) for perifoveal VD and − 0.001 mm2 (95% CI − 0.001 to 0.002; p = 0.001) for the non-flow area for each unit increase in SSI for the comparison of images with different SSI values.

Conclusions
The influence of image quality on OCTA metrics should be considered for image comparisons during follow-up to avoid misinterpretation of small changes in OCTA parameters in patients with diabetes.
Subgingival microbial profile of women with breast cancer: a cross-sectional study
Authors: Bernhard Vivian Rodrigues , Faveri Marcelo , Santos Marciel Silva , Gomes Maria da Conceição Machado , Batitucci Roberta Grasseli , Tanaka Caio Junji , Feres Magda , Feitosa Alfredo 
Published: November 2019

Abstract

Background
Some prospective studies have observed associations between periodontal disease and breast cancer. Therefore, the aim of the present study was to investigate the composition of the subgingival biofilm of women diagnosed with breast cancer, who also presented with chronic periodontitis.

Methods
All subjects underwent clinical and microbiological assessment. Subgingival biofilm samples were taken from at least three sites of 44 women who had breast cancer. The mean levels and proportions of 40 bacterial species were determined by checkerboard DNA-DNA hybridization. Spearman correlation was used to assess possible associations between the mean levels of bacterial species and clinical conditions.

Results
The five species found at the highest levels were Prevotella nigrescens, Actinomyces gerencseriae, Neisseria mucosa, Porphyromonas gingivalis and Tannerella forsythia. The species detected in the lowest counts were Propionibacterium acnes, Streptococcus constellatus, Streptococcus intermedius, Eubacterium saburreum and Streptococcus anginosus. No significant association between levels and proportion of bacterial species and clinical parameters were found.

Conclusion
In conclusion, the results of the present study found no direct association between the subgingival microbiota and breast cancer and an indirect pathway should be addressed in further studies.

Trial registration
Retrospectively registered.
Evaluation of the physical health of adolescent in-patients in generic and secure services: retrospective case-note review
Authors: Carney Rebekah , Imran Shermin , Law Heather , Folstad Siri , Parker Sophie 
Published: November 2019

Aims and methodTo assess physical health needs of adolescent in-patients by routine monitoring. A retrospective analysis of case notes was conducted on a 6-month intake to generic and secure adolescent mental health units in Greater Manchester, UK.ResultsFifty individuals were admitted (52% female, average age 15.84 years). Diagnoses varied and 66% were prescribed medications before admission. All had a physical health assessment, which identified various physical health risk factors. Average body mass index was 25.99 (range 15.8–44), and increased during in-patient treatment for 84% of individuals who had their body mass recorded more than once. A total of 28% of individuals smoked. Lipids and prolactin levels were elevated across the sample.Clinical implicationsThis evaluation strengthens the argument to optimise physical healthcare for adolescent in-patients and develop physical health interventions, particularly given that we observed elevated lipids and prolactin. Physical health and well-being may not be prioritised when assessing and managing young peoples' mental health, despite their increased vulnerability for comorbid conditions.
Well-being and mental health interventions for Indigenous people in prison: systematic review
Authors: Perdacher Elke , Kavanagh David , Sheffield Jeanie 
Published: November 2019

BackgroundIndigenous people are overrepresented in prison populations of colonised justice systems, and Indigenous prisoners in these countries are at a particularly high risk of poor mental health and well-being. There is an acute need to ensure the access of these groups to culturally appropriate, evidence-based interventions.AimsTo conduct a systematic review, evaluating quantitative and qualitative evaluations of mental health and well-being interventions designed for Indigenous people in custody.MethodA search of relevant peer-reviewed journal articles to August 2019 was conducted. The focus was on colonised countries under a Western model of justice and health, including Canada, Australia, New Zealand and the USA. The review utilised Scopus, Web of Science, PubMed, PsycNET, EBSCO, Proquest Criminal Justice Database and Informit.ResultsOf the 9283 articles initially found, only three quantitative and two qualitative evaluations of mental health or well-being interventions for Indigenous people in custody were identified. None were randomised controlled trials. Culturally based interventions appeared to have high acceptability and potential for increased recovery from trauma, reduced alcohol-related problems and lower reoffending. However, no studies quantitatively assessed mental health or well-being outcomes.ConclusionsAs yet there is no high-quality evidence on the impact on mental health and well-being from interventions specifically for Indigenous prisoners, although existing studies suggest programme features that may maximise acceptability and impact. There is a moral, social and practical imperative to build a strong evidence base on this topic.
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study
Authors: Marabelle Aurelien , Le Dung T. , Ascierto Paolo A. , Di Giacomo Anna Maria , De Jesus-Acosta Ana , Delord Jean-Pierre , Geva Ravit , Gottfried Maya , Penel Nicolas , Hansen Aaron R. , Piha-Paul Sarina A. , Doi Toshihiko , Gao Bo , Chung Hyun Cheol , Lopez-Martin Jose , Bang Yung-Jue , Frommer Ronnie Shapira , Shah Manisha , Ghori Razi , Joe Andrew K. , Pruitt Scott K. , Diaz Jr Luis A. 
Published: November 2019

PURPOSE Genomes of tumors that are deficient in DNA mismatch repair (dMMR) have high microsatellite instability (MSI-H) and harbor hundreds to thousands of somatic mutations that encode potential neoantigens. Such tumors are therefore likely to be immunogenic, triggering upregulation of immune checkpoint proteins. Pembrolizumab, an anti‒programmed death-1 monoclonal antibody, has antitumor activity against MSI-H/dMMR cancer. We report data from the phase II KEYNOTE-158 study of pembrolizumab in patients with previously treated, advanced noncolorectal MSI-H/dMMR cancer. PATIENTS AND METHODS Eligible patients with histologically/cytologically confirmed MSI-H/dMMR advanced noncolorectal cancer who experienced failure with prior therapy received pembrolizumab 200 mg once every 3 weeks for 2 years or until disease progression, unacceptable toxicity, or patient withdrawal. Radiologic imaging was performed every 9 weeks for the first year of therapy and every 12 weeks thereafter. The primary end point was objective response rate per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, as assessed by independent central radiologic review. RESULTS Among 233 enrolled patients, 27 tumor types were represented, with endometrial, gastric, cholangiocarcinoma, and pancreatic cancers being the most common. Median follow up was 13.4 months. Objective response rate was 34.3% (95% CI, 28.3% to 40.8%). Median progression-free survival was 4.1 months (95% CI, 2.4 to 4.9 months) and median overall survival was 23.5 months (95% CI, 13.5 months to not reached). Treatment-related adverse events occurred in 151 patients (64.8%). Thirty-four patients (14.6%) had grade 3 to 5 treatment-related adverse events. Grade 5 pneumonia occurred in one patient; there were no other treatment-related fatal adverse events. CONCLUSION Our study demonstrates the clinical benefit of anti–programmed death-1 therapy with pembrolizumab among patients with previously treated unresectable or metastatic MSI-H/dMMR noncolorectal cancer. Toxicity was consistent with previous experience of pembrolizumab monotherapy.
A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children
Authors: Göpel Eric , Rockstroh Denise , Pfäffle Heike , Schlicke Marina , Pozza Susanne Bechtold-Dalla , Gannagé-Yared Marie-Hélène , Gucev Zoran , Mohn Angelika , Harmel Eva-Maria , Volkmann Julia , Weihrauch-Blüher Susann , Gausche Ruth , Bogatsch Holger , Beger Christoph , Klammt Jürgen , Pfäffle Roland 
Published: November 2019

AbstractContextIGF1 receptor mutations (IGF1RM) are rare; however, patients exhibit pronounced growth retardation without catch-up. Although several case reports exist, a comprehensive statistical analysis investigating growth profile and benefit of recombinant human growth hormone (rhGH) treatment is still missing.Objective and methodsHere, we compared IGF1RM carriers (n = 23) retrospectively regarding birth parameters, growth response to rhGH therapy, near final height, and glucose/insulin homeostasis to treated children born small for gestational age (SGA) (n = 34). Additionally, health profiles of adult IGF1RM carriers were surveyed by a questionnaire.ResultsIGF1RM carriers were significantly smaller at rhGH initiation and had a diminished first-year response compared to SGA children (Δ height standard deviation score: 0.29 vs. 0.65), resulting in a lower growth response under therapy. Interestingly, the number of poor therapy responders was three times higher for IGF1RM carriers than for SGA patients (53 % vs. 17 %). However, most IGF1RM good responders showed catch-up growth to the levels of SGA patients. Moreover, we observed no differences in homeostasis model assessment of insulin resistance before treatment, but during treatment insulin resistance was significantly increased in IGF1RM carriers compared to SGA children. Analyses in adult mutation carriers indicated no increased occurrence of comorbidities later in life compared to SGA controls.ConclusionIn summary, IGF1RM carriers showed a more pronounced growth retardation and lower response to rhGH therapy compared to non-mutation carriers, with high individual variability. Therefore, a critical reevaluation of success should be performed periodically. In adulthood, we could not observe a significant influence of IGF1RM on metabolism and health of carriers.
“Our Sense of Purpose”: Speculative Fiction and Systems Reading
Authors: Allan Angela S. 
Published: November 2019

AbstractThis article reads Michael Crichton's Jurassic Park (1990) and Chang-rae Lee's On Such a Full Sea (2014) as works of speculative fiction that engage with the scientific concept of “the system” that emerged during the latter half of the twentieth century. It tracks this history, showing how ecologists and engineers generated their own speculative fictions of possible dystopian futures—environmental collapse, depletion of resources, and overpopulation—through models of dynamic systems. In turn, works of speculative fiction also began to borrow these models for understanding their own relationship to the world around them. This article argues that Jurassic Park and On Such a Full Sea reject the possibility of representing reality as a way to understand what a novel is. While speculative fiction primarily has been read as a popular vehicle for political critique, this article suggests how genre fiction can also generate new forms of literary critique and systems of reading.
Baseline and Exercise Predictors of V˙O2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF
Authors: KARLSEN TRINE , VIDEM VIBEKE , HALLE MARTIN , ELLINGSEN ØYVIND , STØYLEN ASBJØRN , DALEN HÅVARD , DELAGARDELLE CHARLES , LARSEN ALF INGE , HOLE TORSTEIN , MEZZANI ALESSANDRO , VAN CRAENENBROECK EMELINE M. , BECKERS PAUL , PRESSLER AXEL , CHRISTLE JEFFREY W. , WINZER EPHRAIM B. , MANGNER NORMAN , WOITEK FELIX J. , HÖLLRIEGEL ROBERT , SNOER MARTIN , FEIEREISEN PATRICK , VALBORGLAND TORSTEIN , LINKE AXEL , PRESCOTT EVA 
Published: November 2019

ABSTRACT

Purpose
This study aimed to investigate baseline, exercise testing, and exercise training–mediated predictors of change in peak oxygen uptake (V˙O2peak) from baseline to 12-wk follow-up (ΔV˙O2peak) in a post hoc analysis from the SMARTEX Heart Failure trial.

Methods
We studied 215 patients with heart failure with left ventricular ejection fraction (LVEF) ≤35%, and New York Heart Association (NYHA) classes II–III who were randomized to either supervised high-intensity interval training with exercise target intensity of 90%–95% of peak heart rate (HRpeak) or supervised moderate continuous training (MCT) with target intensity of 60%–70% of HRpeak, or who received a recommendation of regular exercise on their own. Predictors of ΔV˙O2peak were assessed in two models: a logistic regression model comparing highest and lowest tertiles (baseline parameters) and a multivariate linear regression model (test/training/clinical parameters).

Results
The change in V˙O2peak in response to the interventions (ΔV˙O2peak) varied substantially, from −8.50 to +11.30 mL·kg−1·min−1. Baseline NYHA (class II gave higher odds vs III; odds ratio (OR), 7.1 (2.0–24.9); P = 0.002), LVEF (OR per percent, 1.1 (1.0–1.2); P = 0.005), and age (OR per 10 yr, 0.5 (0.3–0.8); P = 0.003) were associated with ΔV˙O2peak.
In the multivariate linear regression, 34% of the variability in ΔV˙O2peak was explained by the increase in exercise training workload, ΔHRpeak between baseline and 12-wk posttesting, age, and ever having smoked.

Conclusion
Exercise training response (ΔV˙O2peak) correlated negatively with age, LVEF, and NYHA class. The ability to increase workload during the training period and increased ΔHRpeak between baseline and the 12-wk test were associated with a positive outcome.