bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional and cooking quality improvement of brown rice noodles prepared with extruded rice bran
Authors: Wu Na‐Na , Ma Zhan‐Qian , Li Huan‐Huan , Tian Xiao‐Hong , Fang Yong , Tan Bin 
Published: November 2020

AbstractBackground and objectivesWholegrain foods have gained great attention due to their benefits on health. However, the texture, taste, and cooking quality of wholegrain foods are not good because of the bran in wholegrain. The objectives of this study were to improve the quality of brown rice noodles with rice bran that was treated by extrusion cooking. In this study, brown rice noodles with extruded rice bran (BRN‐ERB) were prepared to improve their quality compared to white rice noodles (WRN) and brown rice noodles with un‐extruded rice bran (BRN).FindingsThe total phenolic, flavonoid, anthocyanin, and dietary fiber contents in BRN‐ERB were 44.87 mg GAE, 36.15 mg RE, 0.11 mg Cy‐3‐O‐G, and 4.48 g per 100 g, respectively, significantly higher than those in BRN and WRN. The BRN‐ERB had the highest antioxidant activities of DPPH, ABTS, and T‐AOC, the highest resistant starch content, and the lowest starch hydrolysis rate among the three types of rice noodles. Seven phenolics, six flavonoids, and three anthocyanins were individually detected in these rice noodles, and BRN‐ERB exhibited higher contents of protocatechuic acid, p‐coumaric acid, ferulic acid, and daidzein than BRN and WRN did. The cooking and textural qualities of BRN‐ERB were improved with lower optimum cooking time and cooking loss, and higher hardness, tensile strength, and elasticity compared to BRN.ConclusionsThe brown rice noodles with extruded rice bran had higher contents of nutritional components than brown rice noodles with un‐extruded rice bran and white rice noodles, and better cooking and textural properties than brown rice noodles with un‐extruded rice bran.Significance and noveltyThe results provided the evidences that brown rice noodles prepared with extruded rice bran might become functional foods from the sources of staple rice products.
Adenoid cystic carcinoma of buccal mucosa: A report of two rare cases and review of literature
Authors: Karimi Abbas , Parhiz Alireza , Eslamiamirabadi Negin , Moradzadeh Khiavi Monir , Derakhshan Samira 
Published: November 2020

AbstractIn the oral cavity, adenoid cystic carcinomas of the buccal mucosa are extremely rare. Minor salivary grand adenoid cystic carcinoma should receive aggressive treatment to achieve negative surgical margins to inhibit recurrence.
Faggot cells in therapy‐related acute myeloid leukemia with inv(16)
Authors: Vega González de Viñaspre Ana , De Miguel Sánchez Carlos , Robles De Castro Diego , Roldán Galiacho Verónica , Mendizabal Abad Arantza , Guinea De Castro José María 
Published: November 2020

AbstractFaggot cells are an uncommon finding in nonacute promyelocytic leukemia, even rarer when observed in mature granulocytic cells. Inv(16) should be dismissed when pre‐eosinophilic granulation and faggot neutrophils are observed.
Without a silhouette
Authors: Sazumi Yosuke , Tokumasu Kazuki , Hagiya Hideharu , Otsuka Fumio 
Published: November 2020

AbstractPrimary effusion lymphoma (PEL) is a kind of malignant lymphoma that develops without a tumor mass. A fluid smear is of no use for the diagnosis of miscellaneous condition. Repeated cell‐block smear with immunostaining is useful for the diagnosis of PEL.
Ectopic parathyroid gland within carotid sheath
Authors: Poh Benjamin Ruimin , Nagadia Rahul Harshad , Tay Gerald Ci‐An 
Published: November 2020

AbstractDuring operative exploration of the neck for parathyroid surgery, the surgeon should always consider possible ectopic locations of the glands and have a reasonable surgical strategy for locating these ectopic glands.
Upper gastrointestinal ischemia as a rare complication of paroxysmal nocturnal hemoglobinuria
Authors: Ueno Masayuki , Shimodate Yuichi , Okada Kazuya , Takaya Ryosuke , Yamamoto Hiroshi , Mizuno Motowo 
Published: November 2020

AbstractWhen patients with PNH present with abdominal symptoms, thrombosis‐induced gastrointestinal injury should be considered; computed tomography and esophagogastroduodenoscopy may help make the diagnosis of this potentially serious complication.
Association of polycythemia vera with positive JAK2V617F mutation and myasthenia gravis: A report of two cases
Authors: Sasi Sreethish , Yassin Mohamed A. , Kamran Sadat , Mnatsakanyan Vazgen 
Published: November 2020

AbstractScreening for MG in patients with PV positive for JAK2V617F mutation can help in early diagnosis and treatment, resulting in a significant reduction in morbidity and mortality.
A weighted local steady‐state determination approach based on the globally optimal economic steady‐states
Authors: Liu Jianbang , Sun Haojie , Lu Yunsong , Hu Jingtao , Zou Tao 
Published: November 2020

AbstractSteady‐state incremental constraints of manipulated variables play a vital role in making given steady‐states satisfy physical limitations and avoiding drastic set‐point changes. Nevertheless, some research reveals that the steady‐state incremental constraints will make the given locally optimal economic steady‐states diverge from the globally optimal economic steady‐states. Therefore, a novel weighted local steady‐state determination approach based on the globally optimal economic steady‐states is presented in this paper. Firstly, the globally and locally optimal economic steady‐states are both evaluated through considering and not considering steady‐state incremental constraints. Then, the angle between them is evaluated and the closest local steady‐state from the globally optimal economic steady‐state is calculated. Subsequently, a new weighted local steady‐state is evaluated by combining the locally optimal economic steady‐state and the closest local steady‐state, in which the weighting coefficient is carefully tuned based on the above‐calculated angle. Finally, several simulations verify that the proposed method could effectively shorten the settling time of controlled systems and improve their economic performance.
Effects of high oil viscosity on oil‐gas downward flow in deviated pipes. Part 1: Experimental setup and flow pattern transitions
Authors: Soto‐Cortes Gabriel , Pereyra Eduardo , Sarica Cem , Rivera‐Trejo Fabian , Torres Carlos 
Published: November 2020

AbstractThis work provides new experimental data on high viscosity oil‐gas flow. A set of 170 downward flow experiments were carried out using a mixture of air and mineral oil (213 mPa · s, 50.8 mm internal diameter, 21.5 m long) for five different elevations: −45°, −60°, −70°, −80°, and −85°. Superficial liquid and gas velocities varied from 0.05 m/s to 0.7 m/s and 0.7 m/s to 7 m/s, respectively. Flow pattern transitions were identified and analyzed. The results helped to evaluate the effects of pipe inclination and liquid viscosity on the stratified‐annular transition, as well as the characterization of subclasses of annular flow pattern, named falling film, liquid slip, and wavy annular. Based on the experimental evidence, the study proposes a constant liquid‐fraction value as a transition between liquid slip and wavy annular flow patterns. A comparison of the present data with the flow pattern predictions of the available models were made. Results show disagreements, which justifies the need for a detailed study of the effects of viscosity and the inclination of the pipe in liquid‐gas downward flow mixtures.
Metal‐Free Catalyzed Cyclization of N‐Methoxybenzamides to Construct Quaternary Carbon‐Containing Isoindolinones
Authors: Zhang Lin‐Bao , Wang Zi‐Chen , Sun Sheng‐Zheng , Ni Shao‐Fei , Wen Li‐Rong , Li Ming 
Published: November 2020

Main observation and conclusionThrough the intramolecular cyclization of N‐methoxybenzamides, a simple and efficient method for constructing valuable isoindolinones under metal‐free conditions was developed. The reaction was featured by employing low‐cost catalyst, simple operation, 100% atomic economy and excellent regioselectivity. Moreover, a detailed computational study on the reaction system has been performed to clarify the mechanism. This protocol tolerated a variety of functional groups and provided a metal‐free protocol for the synthesis of chromane‐ or tetrahydroquinoline‐fused isoindolinones in good yields.
Tumor cell invasiveness in the initial stages of bladder cancer development ‐ A computational study
Authors: Carvalho Joao , Lopes Valeria , Travasso Rui 
Published: November 2020

AbstractBladder cancer is one of the most common types of cancer, being the sixth more frequent in men, and one with higher recurrence rates and overall treatment costs. We introduce an agent‐based computational model of the urothelium, adopting a Cellular Potts Model (CPM) approach to describe both a healthy urothelium and the development of bladder cancer. We focus on the identification of the conditions in which cancer cells cross, by mechanical means, the basement membrane and invade the bladder lamina propria. When within the urothelium the tumor grows in a very constrained environment. These tight conditions imply that the urothelium layer where the tumor initiates greatly determines tumor growth and invasiveness. Moreover, we demonstrate how specific mechanical properties of the cancer cells, as their stiffness or the adhesion to neighboring cells, heavily modulate the critical initial moments of tumor development. We propose that these characteristics should be considered as therapeutic targets to control tumor growth.
A novel algorithm to resolve lack of convergence and checkerboard instability in bone adaptation simulations using non‐local averaging
Authors: Calvo‐Gallego José Luis , Pivonka Peter , García‐Aznar José Manuel , Martínez‐Reina Javier 
Published: November 2020

AbstractCheckerboard is a typical instability in finite element (FE) simulations of bone adaptation and topology optimization in general. It consists in a patchwork pattern with elements of alternating stiffness, producing lack of convergence and instabilities in the predicted bone density. Averaging techniques have been proposed to solve this problem. One of the most acknowledged techniques (node based formulation) has severe drawbacks such as: high sensitivity to mesh density and type of element integration (full vs reduced) and, more importantly, oscillatory solutions also leading to lack of convergence. We propose a new solution consisting in a non‐local smoothing technique. It defines, as the mechanical stimulus governing bone adaptation in a certain integration point of the mesh, the average of the stimuli obtained in the neighbour integration points. That average is weighted with a decay function of the distance to the centre of the neighbourhood. The new technique has been shown to overcome all the referred problems and perform in a robust way. It was tested on a hollow cylinder, resembling the diaphysis of a long bone, subjected to bending or torsion. Checkerboard instability was eliminated and local convergence of bone adaptation was achieved rapidly, in contrast to the other averaging technique and to the model without control of checkerboard instability. The new algorithm was also tested with good results on the same geometry but in a model containing a void, which produces a stress concentration that usually leads to checkerboard instability, like in other applications such as simulations of bone‐implant interfaces.
Increasing comparability among coral bleaching experiments
Authors: Grottoli A. G. , Toonen R. J. , van Woesik R. , Vega Thurber R. , Warner M. E. , McLachlan R. H. , Price J. T. , Bahr K. D. , Baums I. B. , Castillo K. D. , Coffroth M. A. , Cunning R. , Dobson K. L. , Donahue M. J. , Hench J. L. , Iglesias‐Prieto R. , Kemp D. W. , Kenkel C. D. , Kline D. I. , Kuffner I. B. , Matthews J. L. , Mayfield A. B. , Padilla‐Gamiño J. L. , Palumbi S. , Voolstra C. R. , Weis V. M. , Wu H. C. 
Published: November 2020

AbstractCoral bleaching is the single largest global threat to coral reefs worldwide. Integrating the diverse body of work on coral bleaching is critical to understanding and combating this global problem. Yet investigating the drivers, patterns, and processes of coral bleaching poses a major challenge. A recent review of published experiments revealed a wide range of experimental variables used across studies. Such a wide range of approaches enhances discovery, but without full transparency in the experimental and analytical methods used, can also make comparisons among studies challenging. To increase comparability but not stifle innovation, we propose a common framework for coral bleaching experiments that includes consideration of coral provenance, experimental conditions, and husbandry. For example, reporting the number of genets used, collection site conditions, the experimental temperature offset(s) from the maximum monthly mean (MMM) of the collection site, experimental light conditions, flow, and the feeding regime will greatly facilitate comparability across studies. Similarly, quantifying common response variables of endosymbiont (Symbiodiniaceae) and holobiont phenotypes (i.e., color, chlorophyll, endosymbiont cell density, mortality, and skeletal growth) could further facilitate cross‐study comparisons. While no single bleaching experiment can provide the data necessary to determine global coral responses of all corals to current and future ocean warming, linking studies through a common framework as outlined here, would help increase comparability among experiments, facilitate synthetic insights into the causes and underlying mechanisms of coral bleaching, and reveal unique bleaching responses among genets, species, and regions. Such a collaborative framework that fosters transparency in methods used would strengthen comparisons among studies that can help inform coral reef management and facilitate conservation strategies to mitigate coral bleaching worldwide.
The curious case of IL‐33 in homeostasis and infection
Authors: Nadafi Reza , Arens Ramon 
Published: November 2020

AbstractThe importance of interleukin (IL)‐33 in promoting effective antiviral immune responses is evident, yet the critical cellular sources of IL‐33 in homeostasis and infection are largely unknown. In this issue of the European Journal of Immunology, Aparicio‐Domingo et al. [Eur. J. Immunol. 2021. 51: 76–90] explore the main source of IL‐33 expression in lymph nodes (LNs) and dissect its role in LN homeostasis and antiviral adaptive immune response. The authors reveal that fibroblastic reticular cells and lymphatic endothelial cells are both producing IL‐33 in steady‐state LNs. Remarkably, however, by using cell‐type specific deletion approaches, the authors demonstrate that exclusively fibroblastic reticular cells, and not lymphatic endothelial cells, are the critical cellular source for promoting antiviral CD8+ T‐cell responses upon infection. These findings provide an important insight into the role of specific LN stromal cell subsets as potent modulators of antiviral immunity.
Low‐Field High‐Resolution PFG‐NMR to Predict the Size Distribution of Inner Droplets in Double Emulsions
Authors: Khadem Behnam , Parrott Andrew , Nordon Alison , Sheibat‐Othman Nida 
Published: November 2020

AbstractIn double emulsions, the inner and outer droplet size distribution (DSD) determines the quality of the double emulsion and is therefore essential to be measured. Low‐field high‐resolution pulsed‐field gradient nuclear magnetic resonance is used to measure the inner DSD in water‐in‐oil‐in‐water double emulsions. The Gaussian phase distribution approach is employed with a mixture of two normal distributions to predict bimodal inner droplets. This approach allows the prediction of the swelling of inner droplet during storage of double emulsions, and thus to validate a phenomenological population balance model estimating inner droplet swelling. Only a fraction of the inner droplets are found to swell during storage, due to differences in the Laplace pressure, thus leading to the formation of a bimodal size distribution of the inner droplets.Practical Applications: This methodology is useful to predict the evolution of double emulsions during storage, in a wide range of applications, such as food and pharmaceutical products.
Ultra‐orthodoxy and selective voluntarism: How did the Orbán regime react to the first wave of the pandemic?
Authors: Ádám Zoltán 
Published: November 2020

AbstractViktor Orbán's regime in Hungary is a prime example of authoritarian populism in a relatively developed country that has been part of the European Union since 2004. The paper argues that in response to the pandemic, the Orbán government pursued a set of selectively voluntarist policies that have been informed by an ultra‐orthodox, state‐centered worldview that sought to minimize the regime's democratic accountability and to reduce the counter‐mobilization ability of the opposition. These policies had been associated with comparatively low infection and death rates in the first wave of the pandemic, hence enabling high approval ratings for the government despite generating considerable human and economic costs. In light of rising infection and death rates from September 2020, however, it is yet to be seen whether the COVID‐19 crisis, in balance, will reinforce or undermine popular support to the regime.
Clinical and genomic analysis of a large Chinese family with familial cortical myoclonic tremor with epilepsy and SAMD12 intronic repeat expansion
Authors: Zhou Yongxing , Sood Raman , Wang Qun , Carrington Blake , Park Morgan , Young Alice C. , Birnbaum Daniel , Liu Zhao , Ashizawa Tetsuo , Mullikin James C. , Koubeissi Mohamad Z. , Liu Paul 
Published: November 2020

AbstractObjectiveOur goal was to perform detailed clinical and genomic analysis of a large multigenerational Chinese family with 21 individuals showing symptoms of Familial Cortical Myoclonic Tremor with Epilepsy (FCMTE) that we have followed for over 20 years.MethodsPatients were subjected to clinical evaluation, routine EEG, and structural magnetic resonance imaging. Whole exome sequencing, repeat‐primed PCR, long‐range PCR, and PacBio sequencing were performed to characterize the disease‐causing mutation in this family.ResultsAll evaluated patients manifested adult‐onset seizures and presented with progressive myoclonic postural tremors starting after the third or fourth decade of life. Seizures typically diminished markedly in frequency with implementation of antiseizure medications but did not completely cease. The electroencephalogram of affected individuals showed generalized or multifocal spikes and slow wave complexes. An expansion of TTTTA motifs with addition of TTTCA motifs in intron 4 of SAMD12 was identified to segregate with the disease phenotype in this family. Furthermore, we found that the mutant allele is unstable and can undergo both contraction and expansion by changes in the number of repeat motifs each time it is passed to the next generation. The size of mutant allele varied from 5 to 5.5 kb with 549‐603 copies of TTTTA and 287‐343 copies of TTTCA repeat motifs in this family.SignificanceOur study provides a detailed description of clinical progression of FCMTE symptoms and its management with antiseizure medications. Our method of repeat analysis by PacBio sequencing of long‐range PCR products does not require high‐quality DNA and hence can be easily applied to other families to elucidate any correlation between the repeat size and phenotypic variables, such as, age of onset, and severity of symptoms.
Operation optimization of integrated energy systems based on heat storage characteristics of heating network
Authors: Pan Ersheng , Li Hui , Wang Zhidong , Peng Dong , Zhao Lang , Fan Lisha , Wang Yongli , Huang Feifei , Ma Yang , Liu Lin 
Published: November 2020

AbstractWith the development of multi‐energy technology, the electric‐heat integrated energy system has become an important research direction for multi‐energy joint supply. The dynamic characteristics and energy storage capacity of heat supply network provide potential for joint dispatching of electric heating energy system. Aiming at the problem of electric‐heat joint dispatching, this paper presents an operation optimization model of electric‐heat integrated energy system considering the virtual energy storage characteristics of heat supply network. Firstly, according to the characteristics of transmission delay and user temperature fuzzy, the virtual energy storage characteristics of heat supply network are studied, and a model of the dynamic transfer of energy in the heat system was built. Then, the operation optimization model of the electric‐heat integrated energy system is established to minimize the operation cost. In order to improve the robustness of scheduling optimization results, the Monte Carlo Simulation embedded Quantum Particle Swarm Optimization algorithm is proposed to solve the model. In order to prove the validity of the proposed model, this paper selects a park (a 36 node thermal system) in the northwest region of China as a simulation case. The results show that the operation optimization method considering the virtual energy storage of heat supply network will greatly enhance the complementary potential of the electric‐heat integrated energy system and reduce the operation cost of the system.
Synergistic flame retardancy of bis(1‐methoxy‐2,2,6,6‐tetramethylpiperidin‐4‐yl)sebacate and aluminium hypophosphite/melamine hydrobromide in PP
Authors: Qiu Yanyan , Sun Mingmei , Wu Hongzhi , Tang Min , Yan Bo , Tang Linsheng 
Published: November 2020

SummarySynergistic flame retardancy of bis(1‐methoxy‐2,2,6,6‐tetramethylpiperidin‐4‐yl)sebacate (NORSM) and aluminium hypophosphite (ALHP)/melamine hydrobromide (MHB) in polypropylene (PP) was studied by limiting oxygen index (LOI) determination, UL‐94 test and cone calorimetry test. The results reveal that NORSM, together with ALHP/MHB, has an exceptional synergistic flame retardant effect in PP. For the FR‐PP containing 1.0 wt% of ALHP and 1.5 wt% of MHB, combining NORSM in 0.30 wt% concentration can make its LOI increases from 19.0% to 26.3%, the flame retardant effectivity increases from 0.48 to 3.04, the synergistic effectivity is as high as 2.03, the UL‐94 rating is improved from none to V‐2, the fire performance index increases from 58.7 to 91.3, various heat release parameter values are reduced obviously. It is confirmed that NORSM plays the role of synergism with ALHP/MHB mainly through the following mechanisms: the active radicals such as methyl radicals, methoxy radicals, nitro radicals, and aminyl radicals produced by the pyrolysis of NORSM, together with PH3 and HBr, quench active free radical such as ·OH, so the chain reaction of combustion is interrupted and results in a more efficient flame retardant effect in gaseous phase.