bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overlapping volumes in re-irradiation for head and neck cancer—an important factor for patient selection
Authors: Embring Anna , Onjukka Eva , Mercke Claes , Lax Ingmar , Berglund Anders , Bornedal Sara , Wennberg Berit , Friesland Signe 
Published: April 2020

Abstract
Background: There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the re-irradiated volume that might better predict the risk of serious side-effects from treatment.Methods: Fifty-four consecutive patients re-irradiated for HNC cancer were retrospectively analysed. CT images were deformably registered and the dose distributions accumulated after conversion to EQD2. Patients with a cumulative dose of ≥100 Gy in the overlapping volume (V100) were included in the study. Survival data and radiation-related acute and late toxicities were recorded.Results: The overall survival of all included patients at 2 and 5 years was 42.6% and 27.3% respectively and the progression free survival at 2 and 5 years was 32.5% and 28.5% respectively. The overall rate of any event of severe (grade ≥3) acute and late toxicity was 26% and 51%, respectively. We found that severe acute toxicity was more common in patients who had a larger overlapping volume (V100 >mean) where 43% of the patients experienced grade ≥3 acute toxicity, compared to the patients with smaller overlapping volumes (V100 <mean) where only 11% had severe toxicity (p = 0.02). The seemingly high rates of late toxicity in the present study could be due to the use of a more strict definition of re-irradiation. In previous studies also patients with low dose overlap are included and our results imply that there is a risk that previous studies might have overestimated the risk-benefit ratio in re-irradiation of HNC.Conclusions: Our study describes the outcome of a patient material where a more strict definition of the re-irradiated volume is used. With this definition, which could better describe the volume of highest risk for serious complications, we found that larger such overlapping volumes result in an increase in severe acute side-effects. A clear definition of re-irradiation and re-irradiation volumes is of utmost importance for future studies of HNC to make results from different studies comparable.
Geospatial Data Processing Characteristics for Environmental Monitoring Tasks
Authors: BUTENKO Olga , HORELIK Stanislav , ZYNYUK Oleh 
Published: April 2020

Abstract
This paper explores the specifics of working with geospatial data when making decisions about the current environmental status of objects based on Earth space monitoring data. The expediency of sharing statistical data, Earth remote sensing data, and contact measurements is displayed. An analysis of the specifics of this approach to solving the problems of complex processing of multi-temporal a priori data obtained by various shooting equipment was carried out. The existing methods for combining such data are analyzed and possible options for reducing temporary resources and reducing requirements for information resources when working with large volumes of information are considered. It is appropriate to use the method of hierarchical partitioning of multi-temporal image data or images of the analyzed areas obtained at the same time, but from different satellites taking into account the specifics of the shooting equipment and subject to their correspondence to the given a priori geospatial information. One of the criteria for hierarchical partitioning is the identification of areas of greatest correspondence with a priori data with their geographical reference in satellite imagery to reduce the localization time of the corresponding zones throughout the analyzed image array. The economic application effect of this method is substantiated by reducing the computational complexity of costly pattern matching processes, as well as performance improvement of change determination algorithms in topological and geometric characteristics of these objects. An algorithm is shown for detecting changes in heterogeneity in images based on the result of overlay operations with time-differentiated satellite imagery. To confirm the adequacy of the proposed method, the results of its practical implementation are shown on the Ukraine-Poland border area. A comparative analysis of the obtained results with real data is carried out.
Updated Understanding of the Degenerative Disc Diseases - Causes Versus Effects - Treatments, Studies and Hypothesis
Authors: Muresanu Cristian , Somasundaram Siva G. , Neganova Margarita E. , Bovina Elena V. , Vissarionov Sergey V. , Ofodile Okom N.F.C. , Fisenko Vladimir P. , Bragin Valentin , Minyaeva Nina N. , Chubarev Vladimir N. , Klochkov Sergey G. , Tarasov Vadim V. , Mikhaleva Liudmila M. , Kirkland Cecil E. , Aliev Gjumrakch 
Published: April 2020

Background:In this review we survey medical treatments and research strategies, and we discuss why they have failed to cure degenerative disc diseases or even slow down the degenerative process.Objective:We seek to stimulate discussion with respect to changing the medical paradigm associated with treatments and research applied to degenerative disc diseases.Method Proposal:We summarize a Biological Transformation therapy for curing chronic inflammations and degenerative disc diseases, as was previously described in the book Biological Transformations controlled by the Mind Volume 1.Preliminary Studies:A single-patient case study is presented that documents complete recovery from an advanced lumbar bilateral discopathy and long-term hypertrophic chronic rhinitis by application of the method proposed.Conclusion:Biological transformations controlled by the mind can be applied by men and women in order to improve their quality of life and cure degenerative disc diseases and chronic inflammations illnesses.
Increased Heat Shock Protein Expression Decreases Inflammation in Skeletal Muscle During and after Frostbite Injury
Authors: Liskutin Tomas , Batey Jason , Li Ruojia , Schweigert Colin , Mestril Ruben 
Published: April 2020

Background:
Frostbite injury results in serious skeletal muscle damage. The
inflammatory response due to frostbite causes local muscle degeneration. Previous
studies have shown that heat shock proteins (hsps) can protect against inflammation. In
addition, our previous studies showed that increased expression of hsp70 is able to
protect skeletal muscle against cryolesion.

Methods:
Therefore, our aim was to determine if the induction of the heat shock
proteins are able to minimize inflammation and protect skeletal muscle against frostbite
injury.

Results:
In the present study, we used the hsp90 inhibitor, 17-dimethylaminoethylamino-
17-demethoxygeldanamycin (17-DMAG), which was administered within 30
minutes following frostbite injury. Rat hind-limb muscles injected with 17-DMAG
following frostbite injury exhibited less inflammatory cell infiltration as compared to
control rat hind-limb muscles. In agreement with this observation, it has been observed
that increased hsp expression resulted in decreased inflammatory cytokine expression.
Additionally, we found that the administration of 17-DMAG after frostbite injury can
preserve muscle tissue structure as well as function.

Conclusion:
It has been concluded that compounds such as 17-DMAG that induce the
heat shock proteins are able to preserve skeletal muscle function and structure if
injected within 30 minutes after frostbite injury. Our studies provide the basis for the
development of a potential therapeutic strategy to treat the injury caused by frostbite.
Identification of High-Order Single-Nucleotide Polymorphism Barcodes in Breast Cancer Using a Hybrid Taguchi-Genetic Algorithm: Case-Control Study
Authors: Chuang Li-Yeh , Yang Cheng-San , Yang Huai-Shuo , Yang Cheng-Hong 
Published: April 2020

Background
Breast cancer has a major disease burden in the female population, and it is a highly genome-associated human disease. However, in genetic studies of complex diseases, modern geneticists face challenges in detecting interactions among loci.

Objective
This study aimed to investigate whether variations of single-nucleotide polymorphisms (SNPs) are associated with histopathological tumor characteristics in breast cancer patients.

Methods
A hybrid Taguchi-genetic algorithm (HTGA) was proposed to identify the high-order SNP barcodes in a breast cancer case-control study. A Taguchi method was used to enhance a genetic algorithm (GA) for identifying high-order SNP barcodes. The Taguchi method was integrated into the GA after the crossover operations in order to optimize the generated offspring systematically for enhancing the GA search ability.

Results
The proposed HTGA effectively converged to a promising region within the problem space and provided excellent SNP barcode identification. Regression analysis was used to validate the association between breast cancer and the identified high-order SNP barcodes. The maximum OR was less than 1 (range 0.870-0.755) for two- to seven-order SNP barcodes.

Conclusions
We systematically evaluated the interaction effects of 26 SNPs within growth factor–related genes for breast carcinogenesis pathways. The HTGA could successfully identify relevant high-order SNP barcodes by evaluating the differences between cases and controls. The validation results showed that the HTGA can provide better fitness values as compared with other methods for the identification of high-order SNP barcodes using breast cancer case-control data sets.
Synchronization and Scientific Miracle of Chapters and Verses Numbers of The Quran
Authors: Pamil Jon , Munir Akmal , Vebrianto Rian 
Published: April 2020

AbstractThe Quran is the Holy book that is a revelation from God to guide humanity. The Quran has many chapters and verses concerning sciences. This study aimed to explore the content of the Quran using exegesis and all of its components as the main tools to comprehend the Quran. This was a qualitative historic-factual study based on the notion of Tommy Dazwir Paja Putra regarding the scientific miracle of chapters and verses numbers of the Quran. The results show that the numbers of the chapters and verses regarding humans (the prophets and their followers, devout persons, and the ungodly) or things in nature indicate of object location or the object properties. In conclusion, the Quran has scientific signs related to the various branch of sciences such as geography, astronomy, biology, chemistry, archeology, history, paleontology, and other sciences. AbstrakAl-Qur’an adalah kitab suci yang diturunkan Allah swt sebagai pedoman hidup umat manusia. Salah satu kandungan al-Qur’an adalah berkaitan tentang ilmu pengetahuan. Tujuan dari penelitian ini adalah untuk menggali kandungan-kandungan al-Qur’an yang menjadi pedoman kehidupan. Oleh karenanya, ilmu tafsir dengan segala perangkatnya merupakan ilmu utama untuk dapat memahami kandungan al-Qur’an. Jenis penelitian ini adalah kualitatif yang bersifat historis-faktual, terhadap pemikiran tokoh Tommy Dazwir Paja Putra tentang kemukjizatan ilmiah nomor urut surat dan ayat al-Qur’an. Dari hasil penelitian disimpulkan bahwa al-Qur’an manakala berbicara tentang objek-objek di alam seperti objek manusia (para Nabi dan kaumnya, orang-orang shaleh dan orang-orang durhaka), maupun benda-benda di alam, maka ternyata nomor ayat dan nomor surat tersebut sebahagian memberi petunjuk tentang lokasi objek dan sebahagian lagi memberi petunjuk tentang sifat-sifat objek. Sehingga dapat disimpulkan bahwa al-Qur’an mengandung isyarat ilmiah yang terkait dengan banyak cabang ilmu seperti geografi, astronomi, biologi, kimia, arkeologi, sejarah palentologi dan sebagainya. Kata Kunci: Al-Qur’an, Nomor Ayat, Nomor Surat, Kemukjizatan ilmiah.
Ciencia y racionalidad para el futuro del ser humano
Authors: Agazzi Evandro 
Published: April 2020

RESUMENLa idea del progreso de la humanidad se ha basado, en los últimos dos siglos, en el progreso científico-técnico. Por otra parte, se ha considerado a la ciencia como el paradigma de la racionalidad. Las consecuencias negativas producidas por el progreso científico-técnico están provocando un rechazo radical, en diversas capas sociales, de la ciencia y de la racionalidad; y la idea de progreso se ha invertido en la añoranza del pasado. Superando esta imagen neopositivista de la ciencia, el trabajo intenta recuperar para el futuro del ser humano tanto la racionalidad, como la ciencia y la posibilidad del progreso. La racionalidad debe fundarse en valores positivos para el futuro de la humanidad. Por su parte, el progreso debe ser entendido como una tarea por hacer en cada momento, como el compromiso en la realización de aquellos ideales, utilizando la ciencia y la técnica como sus instrumentos más valiosos. PALABRAS CLAVEPROGRESO-CIENCIA-TECNICA-VALORESABSTRACTOver the last two centuries, the idea of human progress has relied upon scientific-technological progress. Meanwhile, science has been considered the paradigm of rationality. however, the negative consequences of scientific-technological progres are causing a radical rejection, at differents social levels, of science and racionality; and the idea of prgress has become a longing for the past. Going beyond this neopositivist image of science, the paper tries to recover rationality, science and the possibility of progress for the future of humanity. Rationality should be based on positive values evisaged to advace it. Progress should be conceived as an open, permanent task using science and technology as its most valued instruments. KEYWORDSPROGRESS- SCIENCE-TECHNOLOGY-VALUES
Reflexión y revelación, los dos elementos del discurrir filosófico. (Una aproximación al pensamiento de María Zambrano)
Authors: Ortega Muñoz Juan Fernando 
Published: April 2020

RESUMENMaría Zambrano intenta superar el racionalismo a partir de la razón poética, síntesis de la intuición intelectual, que llama “revelación”, y de la razón discursiva.PALABRAS CLAVESRAZON POETICA – INTUICION – REFLEXION – RACIONALISMO ABSTRACTMaría Zambrano tries to go beyond rationalism from the “poetic reason”, a synthesis of the intelectual intuition, which she calls “revelation”, and the discursive reason.KEYWORDSPOETIC REASON – INTUITION – REFLECTION – RATIONALISM
Impactos da urbanização e das alterações climáticas no sistema de drenagem do Recife-PE (Impacts of urbanization and climate change in the drainage system of Recife-PE)
Authors: Silva Junior Marcos Antonio Barbosa da , Silva Simone Rosa da 
Published: April 2020

Este trabalho discute a vulnerabilidade do sistema de drenagem urbana da cidade do Recife sob o aspecto urbanístico e climático (precipitações intensas e oscilações de maré). Realizou-se uma pesquisa bibliográfica, apresentando um diagnóstico expedito sobre as peculiaridades da drenagem urbana da cidade, discutindo as intervenções estruturais realizadas no sistema e as medidas implementadas para o enfrentamento das mudanças climáticas. Verificou-se que as ações e medidas que propiciem uma melhor adaptação para a adequação do sistema de drenagem na região, diante da influência das alterações climáticas, ainda são muito tímidas. De uma maneira geral, conclui-se pela necessária gestão integrada do saneamento, a efetiva aplicação das medidas não estruturais, e a utilização combinada de técnicas compensatórias e estruturais que vise à sustentabilidade do sistema, considerando também, os efeitos das alterações climáticas. A B S T R A C T This paper discusses the vulnerability of urban drainage system of the city of Recife considering the urban and climate aspect (intense rainfall and tide oscillations). It presents an expeditious diagnosis on the urban drainage peculiarities of the city, discussing the structural interventions carried out in the system and the measures implemented for coping with climate change, considering the aspect of the urban drainage. It was verified that the actions and measures that allow a better adaptation to the adequacy of the drainage system in the region, given the influence of climate change, are still very timid. It is concluded, in general, in favor of the necessary integrated management of sanitation, the effective implementation of non-structural measures, and the combined use of compensatory and structural techniques aiming at the sustainability of the system, considering the effects of climate change as well. Keywords: Urban planning; climate change; urban drainage.
Faktor-faktor yang Mempengaruhi Budgetary Slack pada Dinas Pengelolaan Keuangan dan Aset Daerah di Propinsi Jawa Barat
Authors: Panjaitan Farida Betniwati , Margaret Rosiana , Carolina Yenni 
Published: April 2020

Anggaran sebagai alat manajemen untuk mengontrol operasional suatu organisasi adalah faktor yang penting untuk mencapai tujuan organisasi tersebut. Dalam organisasi di pemerintahan, anggaran juga digunakan sebagai alat untuk mengukur kemampuan pemerintah dalam mengelola dana keuangan yang digunakan untuk melayani kepentingan umum. Walaupun begitu, pada prakteknya, pengukuran kinerja menggunakan anggaran sebagai tolok ukur seringkali meleset karena adanya kesenjangan dalam anggaran. Berdasarkan fakta ini, maka penelitian ini bertujuan untuk menentukan dampak budget participation dan budget emphasis terhadap budgetary slack. Metode yang digunakan dalam penelitian ini adalah metode analisa deskriptif dengan pendekatan berupa survey. Tipe data yang digunakan berupa data primer. Data dikumpulkan dengan mengirimkan kuesioner pada responden. Empat puluh sembilan buah kuesioner dibagikan pada kepala bagian, kepala sub bagian, dan kepala seksi beserta seluruh staffnya yang terlibat dalam pembuatan anggaran di Dinas Pengelolaan Keuangan dan Aset Daerah Propinsi Jawa Barat. Analisa data dilakukan menggunakan metode Structural Equation Model-Partial Least Square (SEM-PLS) dengan aplikasi program Smart-PLS 3.0. Metode SEM-PLS dipilih dengan pertimbangan bahwa metode ini dapat menganalisa data dalam jumlah yang kecil. Hasil penelitian menunjukkan bahwa budget participation dan budget emphasis memiliki pengaruh yang signifikan terhadap budgetary slack.
Kata kunci: budget participation, budget emphasis, budgetary slack.
Evasão em cursos técnicos a distância: uma investigação no Programa Profuncionário
Authors: Passos Marize Lyra Silva , Barbosa Mariana Biancucci Apolinário , Lacerda Luciane Ferreira 
Published: April 2020

O aumento da oferta de cursos a distância no Brasil é evidente, e com ela as alta taxas de evasão discente que preocupam as instituições de ensino, pois resulta em ociosidade de profissionais, de materiais e de espaço físico. Considerando a apresentação de poucos estudos sobre o tema este trabalho tem o objetivo de ajudar o entendimento deste fenômeno, apresentando uma pesquisa sobre o fenômeno em uma Instituição Pública de Ensino Técnico e Tecnológico no Brasil. A identificação das causas do fenômeno foram baseada nas causa internas e externas ao contexto do curso, propostas por Bittencourt e Mercado (2014). Esta foi uma pesquisa survey de abordagem qualitativa, que utilizou como instrumento de coleta de dados um questionário online enviado para 172 alunos evadidos. A partir da análise dos dados constatou-se que as causas internas foram as que mais motivaram a evasão destes alunos. E os principais itens apontados foram: Orientação da coordenação do curso, Ambiente Virtual de Aprendizagem utilizado pelo curso, os Encontros presenciais, Falta de tempo para estudar, Possuir curso de graduação e Influência familiar. É importante que estratégias de combate à evasão sejam adotadas pela instituição a fim de minimizar o desperdício de recursos públicos.
‘Sovereign Democracy’ and the Politics of Ideology in Putin’s Russia
Authors: Kortukov Dima 
Published: April 2020

Abstract
The concept of sovereign democracy dominated the political discourse in Russia in 2006–8 but lost much of its significance since. In this article, I argue that sovereign democracy is best understood as the response of Russia’s authorities to the threats of democratization, following Eurasian color revolutions. I distinguish between three conceptually distinct aspects of sovereign democracy: (1) a social contract (2) a legitimation discourse; and (3) a counter-revolutionary praxis. These dimensions allow us to understand what functions sovereign democracy fulfilled within the framework of Russia’s authoritarian regime and why it lost its prominence over time.
Quimioterapia y Dermatitis en adultos. Reporte de un caso
Authors: Álava Cedeño María Susana Auxiliadora , Herrera Álava José Carlos , Montesdeoca Chancay Andrea Lissette , Junco Loor Bryan Steeven , Linzan Cedeño Ericka Johanna 
Published: April 2020

Introducción: Las afecciones cutáneas post-quimioterapia, se deben principalmente a los componentes de los tratamientos para el cáncer, la mayor parte del tiempo estas afecciones son denominadas como efecto secundario a la terapia. La dermatitis, es una afección cutánea que se presenta por distintos factores ,el tratamiento utilizado en las dermatitis en pacientes post-quimioterapia, debe comprender varios mecanismos, debido a que esta es una dermatitis reaccional, sin embargo, los emolientes son el tratamiento de primera línea.
Objetivo: Describir un caso clínico de un paciente que padece dermatitis a consecuencia de quimioterapia.
Material y métodos: Se realizó un estudio descriptivo, retrospectivo, presentación de caso clínico sobre de dermatitis post quimioterapia.
Resultados: Se trata de un paciente femenino, que presenta afección en el cuero cabelludo, brazo y codo, lesiones múltiples, de aspecto escamosas, que demanda prurito y ardor, su diagnóstico fue realizado por dermatoscopia y examen físico dermatológico, se estableció un plan terapéutico de urea al 10% crema, Momed crema y Ketocon shampoo, actualmente se encuentra con control y seguimiento.
Conclusiones: La dermatitis post-quimioterapia, se presenta en el 95% de los pacientes con cáncer sometidos a quimioterapia, donde las manifestaciones cutáneas más comunes con la xerosis, eritema, prurito, escama, costra; la alopecia es efecto secundario que también afecta a la gran mayoría de pacientes. el tratamiento de elección en estos pacientes es urea al 10%, mometasona, y shampoo con ketoconazol.
Environmental Literacy Analysis of Junior High School Students in Pekanbaru
Authors: Indri Safitri Wulan , Suryawati Evi , Yustina Yustina 
Published: April 2020

This study aims to determine the environmental literacy profile of junior high school students in Pekanbaru, Indonesia. This study used a survey method with sampling technique by cluster random sampling. The survey was conducted by performing a Test Question and a Middle School Environment Literacy Survey (MSELS) to 372 students. The parameters of this study consisted of ecological knowledge, cognitive skills, attitudes and behavior. The data analysis technique was in the form of descriptive analysis using the average score of achievement of each parameter. The results of this study indicate that the environmental literacy of junior high school students in the Pekanbaru obtained an average value of 61 (with range of 100). The achievement of environmental literacy parameters for ecological knowledge, cognitive skills, attitudes and behaviors amounted to 48, 29, 73 and 71, respectively. Environmental literacy of junior high school students in Pekanbaru is included in the medium category where knowledge and attitudes contribute to environmental literacy.