bluuebunny/crossref_metadata_2025_split huggingface dataset:
Craft and Design in an Age of Climate Crisis
Authors: Luckman Susan , Andrew Jane 
Published: September 2020

AbstractA key tension at the heart of artisanal capitalism is the desire on the part of many makers to work ethically as well as generate an income, but does the world really need more ‘stuff’? Craft practice has long had as a central tenet a profound respect for materials and this sensibility continues to inform much craft practice today. So too do ideas of workmanship, of quality and building to last which also have rich and long traditions in craft practice and are all the more salient in the age of ‘fast fashion’, accelerating disposability and climate crisis. This chapter explores how makers are working to negotiate these tensions and possibly even become part of the solution not the problem.
Towards a New Paradigm of the Creative City or the Same Devil in Disguise? Culture-led Urban (Re)development and Sustainability
Authors: Lavanga Mariangela , Drosner Martina 
Published: September 2020

AbstractRecent attempts have been made by scholars and policy makers to include culture in the sustainability discourse. However, there is a general lack of empirical studies that provide enough insights to understand why culture matters for sustainability. By taking the case of De Ceuvel—a planned workplace for creative and social enterprises in a heavy polluted area in Amsterdam, this chapter aims at answering the question why do cultural and creative entrepreneurs engage in sustainability and in particular in a circular economy model.
Mobile Age: Co-creating Digital Public Services with and for Older Citizens
Authors: Jarke Juliane 
Published: September 2020

AbstractThis book describes and compares three co-creation projects that were conducted in two European cities as part of a larger EU-funded innovation project called Mobile Age. This chapter introduces Mobile Age and presents the project’s framework and methodology for co-creating digital public services. Part of the framework are seven streams of activity that need to be considered. These streams of activity are not sequential but run in parallel and inform each other: (1) governing and managing a co-creation process; (2) continuous recruitment and engagement of stakeholders; (3) co-creating a service concept; (4) working with (open) (government) data; (5) co-creating software; (6) evaluating the co-creation process and its results; and (7) exploiting and disseminating the co-created service. All three co-creation projects featured in this book are described along those streams of activity. In addition, for each project its specific problem focus, target audiences, value propositions and resources are provided.
Co-Creation in Practice III: Co-Creating Age-Friendly Routes (Zaragoza)
Authors: Jarke Juliane 
Published: September 2020

AbstractThis chapter reports on the third co-creation project described in this book. The project was managed by two departments of Zaragoza city council: the Department of Elderly Care and the Technical Office of Participation, Transparency and Open Government. Several activities aiming to improve the lives older citizens have been conducted by the city administration since Zaragoza joined the Global Network of Age-Friendly Cities and Communities. In a consultation process, older citizens had expressed a demand for safe and well-equipped outdoor spaces. Thus, the broad problem focus of this co-creation project was on the improvement of an age-friendly city infrastructure. The co-creation project covered six walks in three different districts. In each district, groups of six to eight older residents defined two relevant routes and collected information (problems and improvements) about them. The data was integrated in a collaborative digital map provided by the city’s Technical Office. The result of the project is an enhanced map service, which allows (older) citizens to report problems in the public (road) infrastructure and/or propose improvements. Their suggestions for improvements enter a list of citizen proposals for a participatory budgeting process.
Learning from Co-creation Practice
Authors: Jarke Juliane 
Published: September 2020

AbstractThis chapter reflects on the learnings from the three co-creation projects featured in this book and attends to the central research questions posed in the introduction. In sum, the chapter presents nine learning points. These cover very different aspects of co-creation ranging from the different roles local government, social care service providers, intermediaries and older citizens may assume, to the implications of embedding co-creation processes in existing service portfolios and strategic policies. The chapter furthermore reflects on different types of co-creation methods (e.g. cultural probes, data tables, data walks) and how they allow for meaningful participation and sharing of knowledge. Ultimately the chapter considers to what extent the openness of a co-creation process impacts on the sustainability of its results and the ways in which co-creation may contribute to joint socio-technical future-making.
Prediction of internal carotid artery aneurysm recurrence by pressure difference at the coil mass surface
Authors: Uno Takehiro , Misaki Kouichi , Nambu Iku , Yoshikawa Akifumi , Kamide Tomoya , Uchiyama Naoyuki , Nakada Mitsutoshi 
Published: September 2020

Abstract
Purpose
A previous study on computational fluid dynamics reported that a high pressure difference (PD) at the surface of a coil mass is a strong predictor of aneurysm recurrence after coil embolization. PD was calculated using a virtual post-coiling model (VM), created by manually cutting the aneurysm by the flat plane from an anatomic model created with pre-coil embolization data; however, its credibility has not been fully evaluated. This study aims to clarify whether PD values calculated using the post-coiling model, which reflects the actual coil plane, are a strong predictor of aneurysm recurrence.

Methods
Fifty internal carotid artery aneurysms treated with endovascular coil embolization were analyzed (7 recanalized, 43 stable). We created and subjected two post-coiling models, namely, VM and the real post-coiling model (RM), constructed from the post-coil embolization data. The relationship between PD and aneurysm recurrence was examined using these models. PD and its constituent three parameters were compared between VM and RM.

Results
PD values calculated using RM showed significantly higher aneurysm recurrence in recurrence group than stable group (p < 0.001), and multivariate analysis showed that PD in RM (p = 0.02; odds ratio, 36.24) was significantly associated with aneurysm recurrence. The receiver operating characteristic analysis revealed that PD values accurately predicted aneurysm recurrence (area under the curve, 0.977; cutoff value, 3.08; sensitivity, 100%; specificity, 97.7%). All four parameters showed a significant correlation with VM and RM (p < 0.001).

Conclusion
Use of PD to predict recurrence after coil embolization can be clinically relevant.
Hyperprogressive disease rarely occurs during checkpoint inhibitor treatment for advanced melanoma
Authors: Schuiveling M. , Tonk E. H. J. , Verheijden R. J. , Suijkerbuijk K. P. M. 
Published: September 2020

Abstract
Introduction
Hyperprogression, characterized by a rapid acceleration in tumor growth, is a novel pattern of progression recently described in patients treated with immune checkpoint inhibitors. This study aims to assess the incidence of hyperprogression in patients with advanced melanoma treated with checkpoint inhibitors.

Methods
Clinical and radiological findings of all advanced melanoma patients who started checkpoint inhibitors between January 2013 and March 2019 in a tertiary academic center in the Netherlands were analyzed. Change in tumor burden was calculated by assessing volumetric tumor growth using the criteria as defined by immune Response Evaluation Criteria in Solid Tumors version 1.1. Hyperprogression was defined as a time to treatment failure less than 2 months with doubling of tumor burden and a twofold increase in tumor growth rate during treatment. Possible hyperprogression was defined as the presence of the first two criteria in the absence of a pre-baseline scan.

Results
Out of 206 treatment episodes in 168 patients, 75 were evaluable for hyperprogression and 87 for possible hyperprogression. Hyperprogression was observed in one patient (1.3%) and possible hyperprogression was observed in one patient (1.1%).

Conclusion
Hyperprogression is rare in melanoma patients treated with immune checkpoint inhibitors. Our data question if hyperprogression really is a biological entity in metastatic melanoma.
Head-to-head comparison of multiple cardiovascular magnetic resonance techniques for the detection and quantification of intramyocardial haemorrhage in patients with ST-elevation myocardial infarction
Authors: Pavon Anna Giulia , Georgiopoulos Georgios , Vincenti Gabriella , Muller Olivier , Monney Pierre , Berchier Gregoire , Cirillo Chiara , Eeckhout Eric , Schwitter Juerg , Masci Pier Giorgio 
Published: September 2020

Abstract
Objectives
T2*-weighted (T2*w) is deemed as a reference standard for post-infarction intramyocardial haemorrhage (IMH). However, high proportion of T2* images is affected by off-resonance artefacts hampering image interpretation. Diagnostic accuracy and precision of alternative techniques for IMH diagnosis and quantification have been seldomly investigated.

Methods and results
Between April 2016 and May 2017, 50 ST-segment elevation myocardial infarction patients (66% male, 57 ± 17 years) and 15 healthy controls (60% male, 58 ± 13) were consecutively enrolled. Subjects underwent head-to-head comparison of single mid-infarct slice acquired on black-blood T2-weighted short-TI-inversion recovery (T2w-STIR), bright-blood T2prep-steady-state-free precession (T2prep-SSFP), and T2/T1 maps for IMH diagnosis and quantification against T2*w. All images were graded for quality (grade 1: very poor; grade 4: excellent) and diagnostic confidence (Likert scale, 1: very unsure and 5: highly confident). Reduced relaxation time/hypointense region (hypocore) embedded in infarct-related oedema on T2 map, T1 map, and T2w-STIR had the best overall diagnostic accuracy (per-subject: 91%, 86%, and 86%, respectively; per segment: 95%, 93%, and 93%, respectively). By mixed-effects analysis, image quality, and diagnostic confidence were higher for T2 map and T1 maps than T2*w (p < 0.05 for both scores). For IMH quantification, hypocore on T2 map and T1 map strongly correlated (Spearman’s r > 0.7, p < 0.001 for both) with IMH extent on T2*w and presented an overall excellent agreement on Bland-Altman analysis. By linear mixed model analysis, absolute hypocore size did not differ among T1-, T2 map, and T2*w. T2/T1 maps had the best intra- and inter-observer reproducibility among CMR techniques.

Conclusion
Hypocore on T2/T1 map is the best alternative technique to T2*w for diagnosing and quantifying IMH in post-STEMI patients.

Key Point
• Mapping techniques are the best alternatives for diagnosing post-infarction intramyocardial haemorrhage.
• Mapping techniques are valuable tools for imaging intramyocardial haemorrhage.
Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes
Authors: Zoppi Carlotta , Nocentini Alessio , Supuran Claudiu T. , Pratesi Alessandro , Messori Luigi 
Published: September 2020

Abstract
Native mass spectrometry is a potent technique to study and characterize biomacromolecules in their native state. Here, we have applied this method to explore the solution chemistry of human carbonic anhydrase I (hCA I) and its interactions with four different inhibitors, namely three sulfonamide inhibitors (AAZ, MZA, SLC-0111) and the dithiocarbamate derivative of morpholine (DTC). Through high-resolution ESI-Q-TOF measurements, the native state of hCA I and the binding of the above inhibitors were characterized in the molecular detail. Native mass spectrometry was also exploited to assess the direct competition in solution among the various inhibitors in relation to their affinity constants. Additional studies were conducted on the interaction of hCA I with the metallodrug auranofin, under various solution and instrumental conditions. Auranofin is a selective reagent for solvent-accessible free cysteine residues, and its reactivity was analyzed also in the presence of CA inhibitors. Overall, our investigation reveals that native mass spectrometry represents an excellent tool to characterize the solution behavior of carbonic anhydrase.

Graphic abstract
Effect of personality traits on the oral health-related quality of life in patients with oral lichen planus undergoing treatment
Authors: Gabriella Dvorak , Klemens Rappersberger , Xiao-hui Rausch-Fan , Corinna Bruckmann , Eva Hofmann 
Published: September 2020

Abstract
Objectives
The aim of this study was to evaluate the relationship between personality traits and perceived treatment success in oral lichen planus.

Material and methods
A total of 53 patients with diagnosed oral lichen planus were evaluated at the time of diagnosis and along the course of their treatment. The visual analogue scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the oral health-related quality of life (OHIP) and the clinical severity. In order to determine the personality trait, the NEO-FFI questionnaire was applied. Data were assessed with the statistical software Stata by a multiple linear regression.

Results
A significant relationship between the two personality traits: “conscientiousness” and “extraversion” and a perceived improvement in oral lichen planus could be observed. The higher the “conscientiousness,” the better the perceived oral health-related quality of life. Furthermore, “extraversion” had a significant influence on the improvement in clinical severity index (P < 0.05).

Conclusions
Personality traits, especially conscientiousness and extraversion, have a significant impact on the perception of therapeutic intervention in oral lichen planus.

Clinical relevance
As personalized patient management is gaining importance and psychosocial factors play a significant role in mucosal diseases, the patient’s psychological profile should be considered in the oral lichen planus management.
Diffusion coefficients in nanoporous solids derived from membrane permeation measurements
Authors: Caro Juergen 
Published: September 2020

AbstractBased on the molecular understanding of the interplay of diffusion and adsorption, new membrane materials can be developed and the operational conditions of gas separation membranes can be optimized. Therefore, numerous diffusion and adsorption studies are conducted to optimize membrane materials. However, in an opposite way, transport or Fickian diffusion coefficientsDTcan be derived from membrane permeation studies with surprising accuracy. From measuring the gas transport through nanoporous supported thin-layer membranes or through mixed matrix membranes with nanoporous fillers in a polymer matrix, the transport diffusion coefficientsDTof gases in novel nanoporous materials such as zeolites, MOFs, COFs… can be estimated.
Effect of long term CPAP therapy on cardiac parameters assessed with cardiac MRI
Authors: Wuest W. , May M. S. , Wiesmueller M. , Uder M. , Schmid A. 
Published: September 2020

AbstractThe obstructive sleep apnoea syndrome (OSAS) is a disorder with a high prevalence and is associated with an elevated cardiovascular risk and increased morbidity and mortality. For longitudinal studies and functional analysis cardiac MRI is regarded as the gold standard. Aim of this study was to evaluate the long-term effect of continuous positive airway pressure (CPAP) therapy on cardiac functional parameters with cardiac Magnetic Resonance Imaging (cMRI). 54 patients with OSAS (mean apnea hypopnea index-AHI: 31) were prospectively enrolled in this study and cMRI was performed before and after 7 months of CPAP therapy. Data were acquired on a 1.5 T MRI and right and left ventricular cardiac function were analysed. CPAP treatment was considered compliant when used ≥ 4 h per night. 24-h blood pressure was measured at baseline and follow up. 33 patients could be assigned to the compliance group. Left ventricular stroke volume (LV SV) and right ventricular ejection fraction (RV EF) improved significantly with CPAP therapy (LV SV from 93 ± 19 to 99 ± 20 ml, p = 0.02; RV EF from 50 ± 6 to 52 ± 6%, p = 0.04). All other cardiac parameters did not change significantly while mean systolic and diastolic blood pressure improved significantly (p < 0.01). 21 patients were assigned to the non-compliance group and were considered as a control group. There were no relevant differences in cardiac parameters between baseline and follow up examination in these patients. CPAP therapy seems to improve LV SV, RV EF, systolic and diastolic blood pressure in OSAS patients, but reproducibility of our results need to be confirmed in a larger patient population.
Pandemic programming
Authors: Ralph Paul , Baltes Sebastian , Adisaputri Gianisa , Torkar Richard , Kovalenko Vladimir , Kalinowski Marcos , Novielli Nicole , Yoo Shin , Devroey Xavier , Tan Xin , Zhou Minghui , Turhan Burak , Hoda Rashina , Hata Hideaki , Robles Gregorio , Milani Fard Amin , Alkadhi Rana 
Published: September 2020

Abstract
Context
As a novel coronavirus swept the world in early 2020, thousands of software developers began working from home. Many did so on short notice, under difficult and stressful conditions.

Objective
This study investigates the effects of the pandemic on developers’ wellbeing and productivity.

Method
A questionnaire survey was created mainly from existing, validated scales and translated into 12 languages. The data was analyzed using non-parametric inferential statistics and structural equation modeling.

Results
The questionnaire received 2225 usable responses from 53 countries. Factor analysis supported the validity of the scales and the structural model achieved a good fit (CFI = 0.961, RMSEA = 0.051, SRMR = 0.067). Confirmatory results include: (1) the pandemic has had a negative effect on developers’ wellbeing and productivity; (2) productivity and wellbeing are closely related; (3) disaster preparedness, fear related to the pandemic and home office ergonomics all affect wellbeing or productivity. Exploratory analysis suggests that: (1) women, parents and people with disabilities may be disproportionately affected; (2) different people need different kinds of support.

Conclusions
To improve employee productivity, software companies should focus on maximizing employee wellbeing and improving the ergonomics of employees’ home offices. Women, parents and disabled persons may require extra support.
Should Google Scholar be used for benchmarking against the professoriate in education?
Authors: Merga Margaret K. , Mat Roni Sayidi , Mason Shannon 
Published: September 2020

AbstractIn the neoliberal environment of contemporary academia, an individual’s research rankings and outputs can shape their career security and progression. When applying for ongoing employment and promotional opportunities, academics may benchmark their performance against that of superior colleagues to demonstrate their performance in relation to their discipline. The H-index and citation rates are commonly used to quantify the value of an academic’s work, and they can be used comparatively for benchmarking purposes. The focus of this paper is to critically consider if Google Scholar be used for benchmarking against the professoriate in education, by weighting up issues of data reliability and participation. The Google Scholar profiles of full professors at top ranked universities in Australia, the United Kingdom and the United States of America are analysed to explore how widespread Google Scholar use is in the education professoriate. Quartiles of impact are established in relation to H-index, with exploration of how gender is distributed across these quartiles. Limitations of using Google Scholar data are highlighted through a taxonomy of quality confounders, and the utility of Google Scholar as a legitimate tool for benchmarking against the professoriate in education is strongly challenged. As metrics continue to rise in their importance for academics’ job security and promotional prospects, reliance on metrics of dubious quality and uneven participation must be questioned.
Assessing the impact of land use and land cover dynamics on water quality of Dal Lake, NW Himalaya, India
Authors: Rather Ishtiyaq Ahmad , Dar Abdul Qayoom 
Published: September 2020

AbstractA dynamic process like land use, if anthropogenically unsustainable, adversely affects the well-being of the land system. Worldwide, water bodies are facing imminent threat due to unsustainable anthropogenic activities. Water quality and ecology are the two characteristics of water bodies, if not preserved, shall have a direct consequence on the well-being of the human systems. Hence it is essential to understand the causes and consequences of the deteriorating water body systems. The condition is particularly grim in Himalayan water body ecosystems, where unplanned and unchecked urbanization has threatened their very existence. In the present study, the dynamics of land use/land cover (LULC) and its impact on the water quality of Dal Lake in Kashmir Himalaya, India has been assessed. We carried out a detailed study wherein changing LULC is analyzed against the deteriorating trophic status of the Dal Lake using time-series of satellite imagery of the lake’s catchment and its water quality data. Results indicated that the water quality of Dal Lake has remarkably deteriorated due to increased nutrient and sediment loads from the catchment, attributed to significant anthropogenic activities in the catchment. Due to unprecedented LULC changes in the catchment, the forest class shows a significantly negative change since the last four decades (1980–2018), corroborating with the ongoing deterioration of physicochemical characteristics of the lake. The analysis shows an increase in all the agents of eutrophication, such as NO3–N, TP, and COD, from 1990 to 2018. The decrease in forest, agriculture, and floating gardens was observed to show a significant negative correlation with the increase in the decadal average values of the COD, NO3–N, and TP for the same corresponding period. Similarly, a positive correlation was found between the increase in built-up, aquatic vegetation, bare surfaces, and these water quality parameters, establishing a strong relationship between the deteriorating condition of the lake and changing LULC. Our findings indicate that changing LULC of the lake’s catchment is one of the critical factors that has significantly contributed toward the deteriorating ecology and water quality of the Dal Lake. This study shall contribute toward the development of the robust conservation strategy in order to save this urban lake from its untimely death.