bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of BSA imprinting mechanism by fluorescence anchoring and host–guest interactions
Authors: Ding Sirui , Wu Jianfeng , Huang Zhen , Chang Sen , Zhang Baoliang 
Published: December 2024

AbstractFor protein imprinting, template molecule anchoring and imprinting site recognition are very important processes. Herein, we have proposed for the first time to use photo‐switchable host–guest interactions between α‐cyclodextrin (α‐CD)‐modified bovine serum albumin (BSA) and azobenzene coated organic covalent framework (COF) to immobilize and elute proteins. A novel surface labeled polymer microspheres (COF‐MIPs) were constructed, which could reduce the mass transfer resistance and accelerate the adsorption process, resulting in the adsorption equilibrium reaching 60 min and the saturated adsorption amount of 563.86 mg/g. Additionally, using guest molecules (azobenzene) to label the imprinted sites allows the correlation of the relationship between the fluorescence intensity and the protein adsorption process. The fluorescence analyses show that the material exhibits excellent adsorption specificity, with imprinting factors greater than 4. This work extended the application of the host–guest interaction between cyclodextrin and azobenzene and provides a new approach for developing protein‐imprinting materials.
Thermal degradation of tertiary amine for CO2 capture: Structure–activity relationships and density functional theory calculations
Authors: Luo Tong , Liu Qi , Xiao Min , Gao Hongxia , Sema Teerawat , Liang Zhiwu 
Published: December 2024

AbstractAqueous amine solution is a promising absorbent for CO2 capture, yet irreversible reaction, that is, degradation can happen for amine and leads to performance decrease and many operating difficulties. Despite numerous research on reaction between amine and CO2 for absorption, the reaction of amine degradation is not fully understood, especially for tertiary amine which is a vital component in constructing high‐performance CO2 absorbent. Considering the variety of tertiary amines, this article studied the thermal stability of five tertiary amine solutions at different temperatures to mimic the regeneration condition. The density functional theory (DFT) calculation was applied to reveal the degradation mechanism. The alkylation reaction that triggered the degradation of tertiary amine was deemed as the limiting step. Then the molecular simulation method was extended to 12 tertiary amines, aiming to further illustrate the influence of molecular structure on the alkylation reaction. These results provide basic data and theoretical guidance for developing the anti‐degradation CO2 absorbent.
SENP1 promotes deacetylation of isocitrate dehydrogenase 2 to inhibit ferroptosis of breast cancer via enhancing SIRT3 stability
Authors: Chen Yaomin , Chen Bin , Hong Yun , Chen Liang , Zheng Shusen 
Published: December 2024

AbstractBreast cancer, one of the most prevalent malignant tumors in women worldwide, is characterized by a poor prognosis and high susceptibility to recurrence and metastasis. Ferroptosis, a lipid peroxide–dependent programed cell death pathway, holds significant potential for breast cancer treatment. Therefore, investigating the regulatory targets and associated mechanisms of ferroptosis is crucial. In this study, we conducted proteomic screening and identified isocitrate dehydrogenase 2 (IDH2) as an important player in breast cancer progression. Our findings were further supported by CCK‐8 assays, transwell experiments, and scratch assays, which demonstrated that the elevated expression of IDH2 promotes breast cancer progression. Through both in vitro and in vivo experiments along with the erastin treatment, we discovered that increased expression of IDH2 confers resistance to ferroptosis in breast cancer cells. By employing Western blot analysis, Co‐IP techniques, and immunofluorescence staining methods, we elucidated the upstream molecular mechanism involving SENP1‐mediated SIRT3 de‐SUMOylatase, which enhances IDH2 enzyme activity through deacetylation, thereby regulating cell ferroptosis. In conclusion, our study highlights the role of the SENP1‐SIRT3 axis in modulating ferroptosis via IDH2 in breast cancer cells, providing valuable insights for developing targeted therapies aimed at enhancing ferroptosis for improved management of breast cancer.
Ancient gene introgression promotes biodiversity of Nymphaea nouchali in Hainan under environmental changes
Authors: Sun Weiyue , Shu Jiangping , Huang Zhicong , He Zuxia , Liu Baodong , Liu Yingrui , Tian Daike , Wu Lei , He Song , Zheng Xilong , Yan Yuehong 
Published: December 2024

AbstractHybridization is common in the plant kingdom. Under the influence of global climate change, an increasing number of hybrid species have experienced significant shifts from the geographical distribution of their parents, making it more difficult to detect ancient gene flows. Nymphaea nouchali is a rare aquatic flower native to Hainan Province. Owing to habitat destruction and human interference, the natural range of N. nouchali has gradually reduced to the point of extinction. To explore how hybrid populations form using RAD‐seq with population genetic analysis, it is shown that there are heterozygous deletions and inbreeding in N. nouchali and a number of ancestral components in Nymphaea lotus, low of genetic differentiation, and little gene flow between N. nouchali and N. lotus, and ancient introgression between ancestors may have been more frequent than gene exchange after the origin of the species. Accordingly, the ancient N. nouchali genotypes were gradually infiltrated by N. lotus genes and their forms changed in Hainan. Potential distribution pattern analysis also predicted the possible distribution of N. lotus in Hainan. This lays a foundation for exploring the natural genetic mechanisms of Nymphaea species formation and evolution.
Bone dimensions relationship with gingival phenotype in smokers and nonsmokers using cone‐beam computed tomography
Authors: Barmar Shiva , Torkzadeh Azadeh , Ghaffari Roshanak , Farhad Shirin Zahra , Aryanezhad Seyed Sasan 
Published: December 2024

AbstractBackgroundThis study aimed to assess the relationship of maxillary alveolar bone thickness (BT) and height (BH) with gingival phenotype (GP) in smokers and nonsmokers using cone‐beam computed tomography (CBCT).MethodsThis cross‐sectional study was conducted on 60 participants. The participants underwent periodontal examination, and their GP was determined by placing a periodontal probe in the gingival sulcus at the midline and observing the transparency. The participants were then assigned to four groups (n = 15) based on their smoking status and GP: thin phenotype/smoker, thick phenotype/smoker, thin phenotype/nonsmoker, and thick phenotype/nonsmoker. BT and BH of the participants were measured in the sagittal plane on CBCT scans at the bone crest and at 2, 4, and 6 mm apical to the crest at the site of maxillary central and lateral incisors. Data were analyzed by two‐way ANOVA and LSD test (alpha = 0.05).ResultsThe distance between the cementoenamel junction (CEJ) of maxillary central and lateral incisors and alveolar bone crest in smokers was significantly greater than that in nonsmokers (p < 0.001). Smoking had no significant effect on alveolar BT at the crestal level or 2, 4, and 6 mm apical to the crest. BT at the crest and 2, 4, and 6 mm apical to the crest was significantly greater in thick, versus thin, GP (p < 0.001).ConclusionSmoking significantly increased the distance between the CEJ and alveolar crest at the site of central and lateral incisors but had no significant effect on BT.Plain Language SummaryThis study found that smoking significantly increased the distance between the cementoenamel junction and the alveolar bone crest in maxillary incisors but did not affect alveolar bone thickness, which was greater in individuals with a thick gingival phenotype compared to those with a thin gingival phenotype.
A Chinese Girl With LIG4 Syndrome and Hematopoietic Stem Cell Transplantation: A Rare Case Report and Review of the Literature
Authors: Jiang Chenjia , Wang Wenyang , Li Yazhou , Liu Xiwang , Zhu Zhirui 
Published: December 2024

ABSTRACTLIG4 syndrome is an exceptionally rare primary immune deficiency. It is an autosomal recessive genetic disease, falling within the spectrum of genetic disorders characterized by impaired DNA damage response mechanisms. Common clinical characteristics encompass microcephaly, growth retardation, developmental delays, facial deformities, variable immune deficiencies, pancytopenia, heightened susceptibility to malignant tumors, and significant clinical and cellular radiosensitivity. Hematopoietic stem cell transplantation (HSCT) is a curative treatment for LIG4 syndrome and may mitigate the long‐term risk of developing lymphoid malignancies by improving tumor surveillance.
Investigating Salt‐Finger Convection Under Time‐Dependent Gravity Modulation in Micropolar Liquids
Authors: Jayan Devika , Tom Clair , Arun Kumar N. 
Published: December 2024

ABSTRACTThis paper investigates how gravity modulation affects salt‐finger convection in a micropolar liquid layer confined between two parallel, infinitely long plates separated by a thin gap. The system is heated and has solute added from above. The study uses linear stability analysis to examine when and how salt‐finger convection, driven by the salt‐finger process, begins. To analyze this, the partial differential equations governing the system are solved numerically using normal mode analysis. The Venezian approach is applied to find the critical Rayleigh number and the solutal Rayleigh number, which are key to understanding the onset of convection. Also, the paper explores how different micropolar fluid parameters—such as the coupling parameter, micropolar heat conduction parameter, couple stress parameter, and inertia parameter—affect the system when gravity modulation is present. It is found that gravity modulation can either stabilize or destabilize convection, depending on its frequency. At very high frequencies (approaching infinity), the effect of gravity modulation becomes minimal, having little impact on the convection process. The paper also examines the relationship between the critical Rayleigh number and the solutal Rayleigh number, which are related to heat and solute concentration, respectively.
Profitability and Bank De‐Branching in the Digital Age: Evidence From Russian Regions
Authors: Zimin Evgenii , Semenova Maria 
Published: December 2024

ABSTRACTThis study examines the relationship between bank de‐branching and profitability in Russian regions depending on the region's internet infrastructure development and financial digital literacy. Using data from 84 Russian regions from 2010 to 2020 and panel data analysis techniques, we test whether the adequacy of internet infrastructure for online banking and financial digital literacy are positively related to bank de‐branching and whether they add to bank de‐branching efficiency in terms of bank profitability. We show that a higher degree of the region's internet infrastructure development and higher levels of financial digital literacy are positively related to bank de‐branching. We observe that banks closing their branches in regions exhibiting higher levels of internet development and financial digital literacy gain more profit from de‐branching. This study adds to the literature by being the first to examine whether financial digital literacy and the development of internet technologies enhance the positive effect of bank de‐branching on bank profitability.
At the Cybersecurity Frontier: Key Strategies and Persistent Challenges for Business Leaders
Authors: Balzano Marco , Marzi Giacomo 
Published: December 2024

ABSTRACTThis study disentangles the cybersecurity landscape, highlighting its strategic role in contemporary digital environments. Aligned with modern holistic management approaches, it uncovers key insights and strategic imperatives by distilling core lessons and identifying ongoing challenges in the field. We emphasize significant contributions to understanding enduring lessons and addressing unresolved challenges in cybersecurity literature. The findings underscore the relevance of adopting a strategic approach to cybersecurity, one that balances technological solutions with human behavior, training, and awareness. Additionally, the study examines the evolving nature of cyber threats, the impact of legal and regulatory frameworks, and ethical dilemmas, emphasizing the need for continuous adaptation and proactive management in the face of increasingly sophisticated digital risks.
The Impact of Board Structure, IT Governance, and Fintech on Green Finance and Sustainability: An Integrated Model
Authors: Almaqtari Faozi A. , Rehman Sheena , Nigam Sadichha , Khan Mohsin 
Published: December 2024

ABSTRACTThe purpose of this study is to investigate the association between board structure, IT governance strategies, innovation, Financial Technologies, green finance, and sustainability performance in Indian banks. The research utilizes a survey of 210 participants drawn from Indian banks. To estimate the results, the study used descriptive statistics and structural equation modeling. The results reveal that a well‐board structure is associated with higher levels of innovation, while the link between board strategic focus and innovation was found to be weak. The findings also indicate that good IT governance leads to good FinTech practices. Further, the results indicate that IT governance and green finance projects are not well aligned. Moreover, the results show that sustainability performance does not appear to be significantly influenced by either green business activities or green investment projects, possibly because green initiatives often have long‐term effects and may not provide noticeable returns over the short run. Therefore, banks need to enhance the integration of innovation, IT governance, and FinTech into board strategies to include more focused green initiatives and projects. The research contributes to academia and practice by integrating various theoretical and practical perspectives, focusing on the intersection of board structures, IT governance strategies, innovation decisions, Fintech integration, green business project execution, and sustainability performance within corporate governance. The findings could shape regulatory frameworks and environmental and social policy debates, enhancing sustainable performance and providing empirical information from real‐world perspectives.
Interpenetrating Network Strategy for Highly Effective Toughening of Epoxy Resin Using Cellulose Microgels
Authors: Li Bingbing , Liao Liqiong , Shi Zhiping , Li Kai , Li Xiang 
Published: December 2024

AbstractEpoxy resin (EP) is widely used in coatings, adhesives, and molding materials. EP's high crosslinking density provides a strong modulus but also leads to reduced elongation at break and lower toughness. In this study, bacterial cellulose microgel (BC‐M) is employed to toughen EP through in situ polymerization, to form an interpenetrating network with EP. Bacterial cellulose nanofibers (BC‐CNF) and ethylated bacterial cellulose microgels (EM) are used as controls to highlight the advantages of the 3D network in enhancing polymer toughness. BC‐M demonstrates the most effective toughening performance for EP. At a filler content of 0.3 wt.%, BC‐M/EP nanocomposites exhibite significant improvements in mechanical properties, including a fracture strength of 107.8 MPa, strain of 3.53%, Young's modulus of 3.09 GPa, and toughness of 1.98 kJ m−3. Compared to EP, these values represent enhancements of 40%, 9.5%, 27.3%, and 58.4%, respectively. Comparisons with BC‐CNF/EP and EM/EP nanocomposites clearly demonstrate that BC‐M provided superior toughening effects. The exceptional toughening capability of BC‐M is attributed to its 3D network structure, which effectively dissipates applied energy, and its strong interfacial interaction with the epoxy matrix through covalent bonding.
How Women and Men with Parkinson's Disease Approach Decision‐Making for Deep Brain Stimulation Surgery
Authors: Fullard Michelle E. , Dafoe Ashley , Shelton Erika , Kern Drew S. , Matlock Dan D. , Morris Megan A. 
Published: December 2024

ABSTRACTBackgroundWomen make up only 23% to 30% of recipients for deep brain stimulation (DBS) surgery for Parkinson's disease (PD), a discrepancy that is not accounted for by differences in disease incidence. One of the many factors that may contribute to this gap includes gender differences in decision‐making.ObjectiveThe aim was to explore how women and men approach the decision for DBS in terms of informational needs, weighing risks and benefits, and decision‐making.MethodsSemistructured interviews were conducted with 33 participants with PD who had undergone DBS evaluation within the past 3 years. Data were analyzed using content analysis.ResultsSixteen women and 17 men participated in interviews. We identified 4 key themes. First, information sources were similar between women and men, and they valued hearing personal experiences. Second, the motivations for DBS surgery were often very personal. Third, the decision‐making process occurred over time, sometimes years. Fourth, although many expressed fear of brain surgery, trust in the surgeon helped many overcome this fear. Women overall had less support than men during decision‐making and after surgery. Women also placed greater value on talking to other women who had undergone DBS, although they had a hard time finding these women. Men, on the contrary, were less often worried about support and valued numerical information when weighing risks and benefits.ConclusionWe found gender differences in information needs, support, motivating factors, and how patients weighed risks and benefits. These differences can be used to inform educational tools and counseling for DBS.
Approximation Algorithm for the Minimum Interval Partial Multi‐Cover Problem
Authors: Ran Yingli , Jin Jianhong , Zhang Zhao 
Published: December 2024

ABSTRACTGiven a set of points on a line, a set of intervals along the line and an integer , each point is associated with a covering requirement , the goal of the minimum interval partial multi‐cover (MinIPMC) problem is to select the minimum number of intervals to fully cover at least points, where a point is fully covered if it belongs to at least selected intervals. This paper presents a 2‐approximation algorithm for the MinIPMC problem.
The World Intellectual Property Organization Treaty on genetic resources and traditional knowledge: Implications for plant science
Authors: Jefferson David J. 
Published: December 2024

Societal Impact StatementThe recently adopted World Intellectual Property Organization Treaty on Intellectual Property, Genetic Resources and Associated Traditional Knowledge (“WIPO Treaty”) is the latest in a series of international legal frameworks designed to strike an appropriate balance between access to genetic and knowledge resources, and their utilization. This opinion piece argues that although the WIPO Treaty is an important milestone in international lawmaking related to the protection of Indigenous peoples' knowledge and resources, it is unlikely to significantly alter extant scientific practices. Therefore, more work will still need to be done to ensure equity in the development of plant‐based innovations.SummaryConcerns about the sourcing of materials and information used in plant breeding and related scientific fields have been widespread for decades. Generally, these preoccupations are rooted in historical and ongoing inequalities, particularly the fact that the benefits resulting from scientific and commercial exploitation of genetic resources and associated traditional knowledge are rarely shared with the people and communities from which they originate. Since the early 1990s, multiple international treaties and national laws have been designed to address concerns over the misappropriation of genetic resources and traditional knowledge, creating a complex web of legal obligations that scientists and research administrators need to navigate. Most recently, in May 2024 the members of the World Intellectual Property Organization adopted a Treaty on Intellectual Property, Genetic Resources and Associated Traditional Knowledge (“WIPO Treaty”, 2024). This opinion piece focuses on the new WIPO Treaty and examines its likely impact on plant breeding and other scientific fields that rely on plant genetic resources. Ultimately, the article argues that the WIPO Treaty is unlikely to add significant impediments to the work of scientists beyond the requirements already imposed under the Convention on Biological Diversity (“CBD”) and its Nagoya Protocol. However, the WIPO Treaty likely will result in the introduction of new administrative requirements for patent filing in many jurisdictions, which may create additional burdens for research administrators, such as personnel in university technology transfer offices.
Characteristics and projected changes in maximum daily precipitation across the globe
Authors: Uchale Nishant N. , Singh Bhupendra Bahadur 
Published: December 2024

AbstractResearch indicates a notable rise in extreme precipitation events across the globe in association with a warmed climate. A considerable chunk of such assessments focuses either on global land areas or specific regions, and these have often been reported on an annual basis. However, it is crucial to note that significant monthly variations occur in the precipitation regimes, especially during seasonal transitions. This research evaluates the statistical characteristics of extreme precipitation globally in observations and Coupled Model Intercomparison Project Phase 6 model projections. Our assessment focuses on maximum daily precipitation on an annual, seasonal, and monthly scale globally for both historical and future climate in the 21st century. The historical assessment is conducted based on the 1980–2014 period, whereas the future climate is sectioned into near future (2040–2060) and far future (2070–2090) focusing on two emission scenarios: SSP245 and SSP585. Monthly assessments of maximum daily precipitation indicate an expansion in the probability density curve's width starting from the boreal winter season going into the peak‐to‐late summer season both in observations and model simulations. Transitioning between unimodal and bimodal distributions in density curves indicates the appearance of one more class of grid points that receive higher precipitation; for example, over the land. Despite large inter‐model spread, future projections assessed based on multimodel mean reveal a substantial rise in maximum daily precipitation in a warmer climate. The reported increase in the intensity of maximum daily precipitation compared with historical climate outweighs the decrease by at least a factor of 1.2 in both scenarios, which is, further, more prominent in SSP585. A large decrease and increase in the intensity of extremes indicates that it may become more variable and intense in future. Additionally, land regions, particularly along the intertropical convergence zone and global monsoon domains, are expected to exhibit more pronounced intensification in future, whereas the decline is mostly confined to tropical–subtropical oceanic regions.