bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous plasmacytosis in a dog (Canis familiaris)
Authors: Mourão de Moraes Renata , de Alencar Nayro Xavier , Maués Tábata , de Souza Kassia Maria , Xavier Márcia de Souza 
Published: December 2024

AbstractCutaneous plasmacytosis is rarely reported in veterinary medicine, but far more described in human medicine. Extramedullary plasmacytomas are plasma cell tumours without bone marrow involvement. This study aimed to report a case of a 7‐year‐old, mixed‐breed dog with a presumptive diagnosis of cutaneous plasmacytosis. At clinical examination, the dog presented 15 cutaneous nodules disseminated through the body. Cytopathological analysis revealed plasmacytoma in 13 out of 15 nodules. Thoracic radiography revealed radiopaque structures suggestive of pulmonary nodules, and abdominal ultrasonography indicated suspicion of a hepatic neoplastic process. The animal died during the diagnostic screening period, with a survival of 16 days from the initial consultation. Thus, further confirmatory tests such as histopathology and immunohistochemistry were not performed, and the pulmonary and hepatic lesions were not assessed. This report demonstrates the importance of cytopathology in the presumptive diagnosis of cutaneous plasmacytosis in a dog, considering the absence of other complementary examinations.
Serious Games Beyond Entertainment and Learning: An Evaluation Methodology for Assessing Awareness Raising, Empathy, and Social Change
Authors: Ntoa Stavroula , Ntagianta Anastasia , Flores Fernanda , Kolek Lukáš , Petrova Alexandra , Apostolakis Konstantinos C. , Stamou Stefania , Margetis George , Stephanidis Constantine 
Published: December 2024

AbstractSerious games have emerged as a powerful tool for achieving targeted outcomes beyond entertainment, such as learning or raising awareness about a topic. Considering their pervasiveness and wide adoption in the educational domain, traditional assessment approaches of these games have predominantly focused on their entertainment value and achievement of learning objectives. This paper proposes a comprehensive evaluation framework that goes beyond traditional dimensions to include aspects relevant to empathy raising and attitude change. The proposed framework has been validated through three user studies, assessing entertainment, historical awareness, empathy raising, and attitude change for three games, involving in total 98 high school students. Results from the studies are presented, as well as implications and lessons learned regarding the overall methodological approach, the evaluation instruments used, and the procedures followed.
Speed of the Downstream Turbulent Front in Pipe Flow
Authors: Song Baofang , Xu Duo 
Published: December 2024

AbstractThe mechanism that determines the propagation speed of the upstream turbulent front of pipe flow turbulence has been proposed recently in our earlier work. It states that the local flow speed at the most upstream tip of the front, where transition to turbulence takes place, determines the global propagation speed of the front. The key was shown to be determining the radial position of the transition point, which can be approximated by the radial position of low-speed streaks at the front tip. In this paper, we will verify whether or not this mechanism also applies to the downstream front. However, the transition is not through near wall streaks, but takes place near the pipe center at the downstream front tip. Through an energy budget analysis in the front region, we managed to determine the position of the transition point, and our results suggest that the mechanism indeed also applies to the downstream front.
On Low-Scalar Patches in Turbulent Wakes with and Without Free-Stream Turbulence
Authors: Kohan Khashayar F. , Buxton Oliver R. H. , Gaskin Susan J. 
Published: December 2024

AbstractHigh-resolution, time-resolved, simultaneous particle image velocimetry and planar laser-induced fluorescence are performed to study the characteristics of the low-scalar ‘holes’ in a planar wake exposed to various cases of background turbulence as parameterized by the turbulence intensity and length scale. Several metrics are employed to distinguish the engulfed holes from those generated internally. It is found that beyond a transition distance of 18 Kolmogorov microscales from the wake boundary, holes exhibit comparable behaviour to the wake core, suggesting their generation by local turbulence. It is further revealed that engulfment constitutes less than 1% of the total mass flux in the far-field, regardless of the strength of incoming turbulence intensity.
A Corpus-Based Study of the Externality of Emotions in Swahili and Japanese
Authors: Kahumburu Monica , Matsumoto Yo 
Published: December 2024

AbstractThis chapter discusses cultural conceptualization of emotions. Specifically, we examine various ways in which emotions are metaphorically conceptualized as external entities such as an outer force or an entity coming into an experiencer (Kahumburu in Rev Cogn Linguist 14:416–441, 2016). Based on corpus data retrieved for five different Swahili and Japanese nouns of emotion, we show that in both languages, many emotions are depicted as externally originating. At the same time, these two languages differ in the way such expressions are adopted for particular emotions (e.g., anger can be conceptualized primarily as externally originating in Swahili and internally originating in Japanese). Moreover, the two languages differ in adopting different types of external entities (e.g., sadness is typically conceptualized as an entity moving into an experiencer in Swahili, but frequently as liquid surrounding an experiencer in Japanese). We further suggest some cultural/environmental backgrounds for the preferred use of certain types in Swahili and Japanese.
Golgi pH elevation due to loss of V-ATPase subunit V0a2 function correlates with tissue-specific glycosylation changes and globozoospermia
Authors: Kopp Johannes , Jahn Denise , Vogt Guido , Psoma Anthi , Ratto Edoardo , Morelle Willy , Stelzer Nina , Hausser Ingrid , Hoffmann Anne , de los Santos Miguel Rodriguez , Koch Leonard A. , Fischer-Zirnsak Björn , Thiel Christian , Palm Wilhelm , Meierhofer David , van den Bogaart Geert , Foulquier François , Meinhardt Andreas , Kornak Uwe 
Published: December 2024

AbstractLoss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used knock-out (Atp6v0a2−/−) and knock-in (Atp6v0a2RQ/RQ) mice harboring the R755Q missense mutation selectively abolishing V0a2-mediated proton transport to investigate the WSS pathomechanism. Homozygous mutants from both strains displayed a reduction of growth, dermis thickness, and elastic fiber formation compatible with WSS. A hitherto unrecognized male infertility due to globozoospermia was evident in both mouse lines with impaired Golgi-derived acrosome formation and abolished mucin-type O-glycosylation in spermatids. Atp6v0a2−/− mutants showed enhanced fucosylation and glycosaminoglycan modification, but reduced levels of glycanated decorin and sialylation in skin and/or fibroblasts, which were absent or milder in Atp6v0a2RQ/RQ. Atp6v0a2RQ/RQ mutants displayed more abnormal migration of cortical neurons, correlating with seizures and a reduced O-mannosylation of α-dystroglycan. While anterograde transport within the secretory pathway was similarly delayed in both mutants the brefeldin A-induced retrograde fusion of Golgi membranes with the endoplasmic reticulum was less impaired in Atp6v0a2RQ/RQ. Measurement of the pH in the trans Golgi compartment revealed a shift from 5.80 in wildtype to 6.52 in Atp6v0a2−/− and 6.25 in Atp6v0a2RQ/RQ. Our findings suggest that altered O-glycosylation is more relevant for the WSS pathomechanism than N-glycosylation and leads to a secondary dystroglycanopathy. Most phenotypic and cellular properties correlate with the different degrees of trans Golgi pH elevation in both mutants underlining the fundamental relevance of pH regulation in the secretory pathway.
Pharmacotherapeutic actions related to drug interaction alerts – a questionnaire study among Swedish hospital interns and residents in family medicine
Authors: Tukukino Carina , Parodi López Naldy , Lönnbro Johan , Wallerstedt Susanna M. , Svensson Staffan A. 
Published: December 2024

Abstract
Purpose
To explore how hospital interns and residents specialising in family medicine act on drug interaction alerts in a specific patient case, and on interaction alerts in general.

Methods
A 4-page questionnaire, including a fictional patient case (73-year-old woman; 10 drugs in the medication list triggering 11 drug interaction alerts) and questions regarding the use of interaction alerts in general, was distributed to interns and residents during educational sessions (November‒December 2023). The respondents were instructed to consider what actions they would take “a normal day at work” due to the risk of interactions between the patients’ drugs. In the general questions, the respondents were asked how often they access the detailed interaction information (from 1 = never to 5 = always) provided by the knowledge resource, in relation to the alert classification (D = clinically significant, should be avoided; C = clinically significant, can be handled by, e.g., dose adjustment).

Results
The questionnaire was completed by 55 interns and 69 residents (response rate: 98%). In the patient case, the respondents acted on a median of 4 (range: 0‒8) drugs, most often concerning repaglinide (in a D interaction alert with clopidogrel; 96% of the interns and 96% of the residents suggested action), and omeprazole (in three C interaction alerts with citalopram, clopidogrel, and levothyroxine, respectively; 71% and 83% suggested action). Among the respondents who answered the questions about how often (rated 4/5) they access more detailed information about interactions, 56 (59%) did so for D versus 29 (31%) for C alerts (P < 0.001).

Conclusion
Physicians act on drug interaction alerts selectively, and the alert classifications seem to guide how they are used.
On semidirect products of quantale enriched monoids
Authors: Borlido Célia 
Published: December 2024

Abstract
We consider monoids equipped with a compatible quantale valued relation, which we call quantale enriched monoids, and study semidirect products of such structures. It is well-known that semidirect products of monoids are closely related to Schreier split extensions which, in the setting of monoids, play the role of split extensions of groups. We will thus introduce certain split extensions of quantale enriched monoids, which generalize the classical Schreier split extensions of monoids, and investigate their connections with semidirect products. We then restrict our study to a class of quantale enriched monoids whose behavior mimics the fact that the preorder on a preordered group is completely determined by its cone of positive elements. Finally, we instantiate our results for preordered monoids and compare them with existing literature.
The three stages of polytrauma rehabilitation– a recommendation and a systematic literature review on behalf of SICOT
Authors: Klingebiel Felix Karl-Ludwig , Landre Vincent , Hasegawa Morgan , Kalbas Yannik , Hanschen Marc , Sawauchi Kenichi , Mohamed Sayid Omar , Zarti Mohammed , Zain-ur-Rehmann Mohammad , Aroojis Alaric , Rajasekaran Shanmuganathan , Pape Hans-Christoph , Pfeifer Roman ,   on behalf of SICOT Trauma & Rehabilitation Research Group, Das Sakti Prasad , Herard Patrick , Korobushkin Gleb , Pasquale Caterina , Yuen Denis 
Published: December 2024

Abstract

Purpose
Polytrauma presents a devastating event with great impact on the patient’s life. While we are taking great care of improving our treatment algorithms, the rehabilitation often takes place outside of our direct field of vision. Yet, adequate rehabilitation is crucial for the patients to regain their former lives. The aim of this study, on the behalf of SICOT Trauma & Rehabilitation Research Group, was to identify rehabilitation strategies and standards in existing scientific literature.

Methods
A systematic literature search of MEDLINE and Embase from 2000 to 2023 was conducted. Inclusion criteria was the description of polytrauma rehabilitation strategies in the acute, post-acute or long-term stage. Reported treatment aims, conducted therapies and challenges were extracted and stratified to either of the stages.

Results
A total of 5212 studies were identified and 6 reviews and one original study were included according to our criteria. Overall, no article of higher evidence on how to perform polytrauma rehabilitation could be identified. From the available literature, disciplines involved in the rehabilitation could be described such as major challenges along the rehabilitation process.

Conclusion
This study highlights the need for standardized polytrauma rehabilitation algorithms. Whereas we could identify important information about each rehabilitation stage, we did not encounter specific evidence for prioritization of different therapies or algorithms of treatment. Polytrauma rehabilitation needs to shift from eminence to evidence.
From surface roughness to crater formation in a 2D multi-scale simulation of ultrashort pulse laser ablation
Authors: Thomae N. , Stabroth M. , Vollmann J. , Döring M. , Redka D. , Huber H. P. , Schmidt M. 
Published: December 2024

Abstract
Surface roughness plays a critical role in ultrashort pulse laser ablation, particularly for industrial applications using burst mode operations, multi-pulse laser processing, and the generation of laser-induced periodic surface structures. Hence, we address the impact of surface roughness on the resulting laser ablation topography, comparing predictions from a simulation model to experimental results. We present a comprehensive multi-scale simulation framework that first employs finite-difference-time-domain simulations for calculating the surface fluence distribution on a rough surface measured by atomic-force-microscopy followed by the two-temperature model coupled with hydrodynamic/solid mechanics simulation for the initial material heating. Lastly, a computational fluid dynamics model for material relaxation and fluid flow is developed and employed. Final state results of aluminum and AISI 304 stainless steel simulations demonstrated alignment with established ablation models and crater dimension prediction. Notably, Al exhibited significant optical scattering effects due to initial surface roughness of 15 nm—being 70 times below the laser wavelength -leading to localized, selective ablation processes and substantially altered crater topography compared to idealized conditions. Contrary, AISI 304 with

$${R}_{\text{q}}$$

R
q

surface roughness of 2 nm showed no difference. Hence, we highlight the necessity of incorporating realistic, material-specific surface roughness values into large-scale ablation simulations. Furthermore, the induced local fluence variations demonstrated the inadequacy of neglecting lateral heat transport effects in this context.
Investigation of the temperature-dependent functioning of BiFeO3 as a ferroelectric material through X-ray diffraction analysis
Authors: Sayed Rana , Hassanien Ayat , Hashim Hany , Mabied Ahmed , Ramadan Ahmed , Soltan Soltan 
Published: December 2024

Abstract
In recent years, Bismuth Ferrite (BiFeO3, BFO) has emerged as a promising multiferroic material due to its high antiferromagnetic Néel temperature (TN ~ 623–643 K) and ferroelectric Curie temperature (TC ~ 1083–1103 K). These properties make BFO a strong candidate for exhibiting a magnetoelectric effect even at room temperature. Understanding the temperature-dependent ferroelectric behavior of BFO is crucial for optimizing its performance in applications where stable ferroelectric behavior at operational temperatures is essential for enhancing device efficiency, stability, and functionality. This study investigates the impact of temperature on the crystallographic characteristics (unit cell type, bond lengths, and dimensions) and ferroelectric performance of BFO. X-ray diffraction and electrical hysteresis measurements confirm the presence of a ferroelectric phase with a rhombohedral R3c structure, along with two phase transitions: the first around 600 K from ferroelectric to paraelectric, and the second near 1050 K from paraelectric back to ferroelectric.
Isothiocyanates induce autophagy and inhibit protein synthesis in primary cells via modulation of AMPK-mTORC1-S6K1 signaling pathway, and protect against mutant huntingtin aggregation
Authors: Brokowska Joanna , Herman-Antosiewicz Anna , Hać Aleksandra 
Published: December 2024

Abstract

Purpose
Autophagy is a degradation process whose activation underlies beneficial effects of caloric restriction. Isothiocyanates (ITCs) induce autophagy in cancer cells, however, their impact on primary cells remains insufficiently explored, particularly in non-epithelial cells. The aim of this study was to investigate whether ITCs induce autophagy in primary (non-immortalized) mesenchymal cells and if so, to determine the molecular mechanism underlying its activation and consequences on cell functioning.

Methods
Primary human dermal fibroblasts (HDFa) and prostate cancer cells (PC3) as well as two ITCs, sulforaphane and phenethyl isothiocyanate, were applied. Cell viability was measured by the MTT test, protein synthesis - by 3H-leucine incorporation, and protein level - by immunoblotting. A number of mutant huntingtin (mHtt) aggregates was assessed by fluorescence microscopy.

Results
Both ITCs efficiently induced autophagy in fibroblasts which coincided with suppression of mTORC1 – a negative autophagy regulator - and protein synthesis arrest. A dephosphorylation of mTORC1 substrate, S6K1, and ribosomal S6 protein was preceded by activation of AMPK, an inhibitor of mTORC1 and autophagy activator. A similar response was observed in phenethyl isothiocyanate-treated prostate cancer cells. We also showed that ITCs-induced autophagy and/or translation block do not affect cells viability and can protect cells against an accumulation of mHtt aggregates – a main cause of Huntington’s disease.

Conclusion
Our study showed that ITCs induce autophagy and inhibit protein synthesis in both primary mesenchymal and cancer cells via modulation of the AMPK-mTORC1-S6K1 pathway. Moreover, it suggests that ITCs might have a potential in developing therapeutics for Huntington’s disease.
TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury
Authors: Hartmannsberger Beate , Ben-Kraiem Adel , Kramer Sofia , Guidolin Carolina , Kazerani Ida , Doppler Kathrin , Thomas Dominique , Gurke Robert , Sisignano Marco , Kalelkar Pranav P. , García Andrés J. , Monje Paula V. , Sammeth Michael , Nusrat Asma , Brack Alexander , Krug Susanne M. , Sommer Claudia , Rittner Heike L. 
Published: December 2024

AbstractNerve injury causes neuropathic pain and multilevel nerve barrier disruption. Nerve barriers consist of perineurial, endothelial and myelin barriers. So far, it is unclear whether resealing nerve barriers fosters pain resolution and recovery. To this end, we analysed the nerve barrier property portfolio, pain behaviour battery and lipidomics for precursors of specialized pro-resolving meditators (SPMs) and their receptors in chronic constriction injury of the rat sciatic nerve to identify targets for pain resolution by resealing the selected nerve barriers. Of the three nerve barriers—perineurium, capillaries and myelin—only capillary tightness specifically against larger molecules, such as fibrinogen, recuperated with pain resolution. Fibrinogen immunoreactivity was elevated in rats not only at the time of neuropathic pain but also in nerve biopsies from patients with (but not without) painful polyneuropathy, indicating that sealing of the vascular barrier might be a novel approach in pain treatment. Hydroxyeicosatetraenoic acid (15R-HETE), a precursor of aspirin-triggered lipoxin A4, was specifically upregulated at the beginning of pain resolution. Repeated local application of resolvin D1-laden nanoparticles or Fpr2 agonists sex-independently resulted in accelerated pain resolution and fibrinogen removal. Clearing macrophages (Cd206) were boosted and fibrinolytic pathways (Plat) were induced, while inflammation (Tnfα) and inflammasomes (Nlrp3) were unaffected by this treatment. Blocking TAM receptors (Tyro3, Axl and Mer) and tyrosine kinase receptors linking haemostasis and inflammation completely inhibited all the effects. In summary, nanoparticles can be used as transporters for fleeting lipids, such as SPMs, and therefore expand the array of possible therapeutic agents. Thus, the Fpr2–Cd206–TAM receptor axis may be a suitable target for strengthening the capillary barrier, removing endoneurial fibrinogen and boosting pain resolution in patients with chronic neuropathic pain.
Outcome of pelvic ring injuries
Authors: Gänsslen Axel , Lindahl Jan , Krappinger Dietmar , Lindtner Richard A. , Staresinic Mario 
Published: December 2024

AbstractOutcome evaluation is of major importance to provide data to analyze the value of the chosen treatment concept. Despite an increasing effort of analyzing outcome after treatment of different pelvic ring injuries, a mixture of different outcome parameters is in use. The Majeed score is most frequently used for mid- to long-term evaluation and the quality of life is analyzed using the SF-36 score. The lack in nearly all studies is that different treatment concepts are used, and only selected evaluation parameters are reported. Until today, no well-accepted standardized measurement instruments are available to analyze the clinical and radiological results after pelvic ring injuries. Overall, stability-based long-term sequelae can be expected with increasing complaints from stable type A injuries to completely unstable type C injuries. Beside a fracture-type specific treatment, concomitant injuries of other injury regions and associated local pelvic injuries (complex pelvic trauma) seem to additionally influence the results. Results of treatment of specific fracture types are sparse as a wide range of different injury types and different treatment concepts are analyzed within these analyses. A sufficient pelvic outcome instrument which addresses relevant pelvic outcome parameters is still missing. Thus, future evaluation of long-term results after pelvic ring. injuries should include prospective, multicenter outcome studies with comparable parameters.