bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlling the Chirping of Chorus Waves via Magnetic Field Inhomogeneity
Authors: Wu Yifan , Tao Xin , Zonca Fulvio , Chen Liu , Wang Shui 
Published: May 2020

AbstractWhistler mode chorus waves are coherent electromagnetic emissions in planetary magnetospheres, characterized by rising‐tone or falling‐tone chirping elements. Understanding the cause of different chirping directions and their properties is an important step in resolving the long‐standing problem of nonlinear chorus generation. We report here, for the first time, particle‐in‐cell simulations of bidirectional chirping of whistler waves in a uniform magnetic field and falling‐tone‐only chirping in an inhomogeneous field. Combined with previous simulations of rising‐tone‐only emissions, we demonstrate that the background magnetic field inhomogeneity is not required for chirping of chorus, but it plays a key role in determining the chirping direction. The findings of the present work also unveil the critical role of the dipole geometry of Earth's magnetic field in causing the statistical predominance of rising‐tone chorus and the oblique propagation of falling‐tone chorus.
Impact of Coronavirus Outbreak on NO2 Pollution Assessed Using TROPOMI and OMI Observations
Authors: Bauwens M. , Compernolle S. , Stavrakou T. , Müller J.‐F. , van Gent J. , Eskes H. , Levelt P. F. , van der A R. , Veefkind J. P. , Vlietinck J. , Yu H. , Zehner C. 
Published: May 2020

AbstractSpaceborne NO2 column observations from two high‐resolution instruments, Tropospheric Monitoring Instrument (TROPOMI) on board Sentinel‐5 Precursor and Ozone Monitoring Instrument (OMI) on Aura, reveal unprecedented NO2 decreases over China, South Korea, western Europe, and the United States as a result of public health measures enforced to contain the coronavirus disease outbreak (Covid‐19) in January–April 2020. The average NO2 column drop over all Chinese cities amounts to −40% relative to the same period in 2019 and reaches up to a factor of ~2 at heavily hit cities, for example, Wuhan, Jinan, while the decreases in western Europe and the United States are also significant (−20% to −38%). In contrast with this, although Iran is also strongly affected by the disease, the observations do not show evidence of lower emissions, reflecting more limited health measures.
LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption
Authors: Zhang Ruilin , Li Junhui , Li Gongchen , Jin Fujun , Wang Zuolin , Yue Rui , Wang Yibin , Wang Xiaogang , Sun Yao 
Published: May 2020

AbstractActivation of osteoclasts during orthodontic tooth treatment is a prerequisite for alveolar bone resorption and tooth movement. However, the key regulatory molecules involved in osteoclastogenesis during this process remain unclear. Long noncoding RNAs (lncRNAs) are a newly identified class of functional RNAs that regulate cellular processes, such as gene expression and translation regulation. Recently, lncRNAs have been reported to be involved in osteogenesis and bone formation. However, as the most abundant noncoding RNAs in vivo, the potential regulatory role of lncRNAs in osteoclast formation and bone resorption urgently needs to be clarified. We recently found that the lncRNA Nron (long noncoding RNA repressor of the nuclear factor of activated T cells) is highly expressed in osteoclast precursors. Nron is downregulated during osteoclastogenesis and bone ageing. To further determine whether Nron regulates osteoclast activity during orthodontic treatment, osteoclastic Nron transgenic (Nron cTG) and osteoclastic knockout (Nron CKO) mouse models were generated. When Nron was overexpressed, the orthodontic tooth movement rate was reduced. In addition, the number of osteoclasts decreased, and the activity of osteoclasts was inhibited. Mechanistically, Nron controlled the maturation of osteoclasts by regulating NFATc1 nuclear translocation. In contrast, by deleting Nron specifically in osteoclasts, tooth movement speed increased in Nron CKO mice. These results indicate that lncRNAs could be potential targets to regulate osteoclastogenesis and orthodontic tooth movement speed in the clinic in the future.
Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque
Authors: Tang Boyu , Gong Tao , Cui Yujia , Wang Lingyun , He Chao , Lu Miao , Chen Jiamin , Jing Meiling , Zhang Anqi , Li Yuqing 
Published: May 2020

AbstractThe oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from the dental plaque of a healthy human population. Broth microdilution minimum inhibitory concentrations (MICs) revealed that all the isolates were nonsusceptible to oxacillin and penicillin G. Most of them were also resistant to trimethoprim (65.7%) and erythromycin (54.3%). The resistance to multiple antibiotics was found to be largely due to the acquisition of plasmid-borne genes. The mecA and dfrA genes were found in all the isolates, mostly dfrG (80%), aacA-aphD (20%), aadD (28.6%), aphA3 (22.9%), msrA (5.7%), and the ermC gene (14.3%). Classical mutational mechanisms found in these isolates were mainly efflux pumps such as qacA (31.4%), qacC (25.7%), tetK (17.1%), and norA (8.6%). Multilocus sequence type analysis revealed that sequence type 59 (ST59) strains comprised 71.43% of the typed isolates, and the eBURST algorithm clustered STs into the clonal complex 2-II(CC2-II). The staphyloccoccal cassette chromosome mec (SCCmec) type results showed that 25 (71.43%) were assigned to type IV. Moreover, 88.66% of the isolates were found to harbor six or more biofilm-associated genes. The aap, atlE, embp, sdrF, and IS256 genes were detected in all 35 isolates. This research demonstrates that biofilm-positive multiple-antibiotic-resistant ST59-SCCmec IV S. epidermidis strains exist in the dental plaque of healthy people and may be a potential risk for the transmission of antibiotic resistance.
Abstract representations of events arise from mental errors in learning and memory
Authors: Lynn Christopher W. , Kahn Ari E. , Nyema Nathaniel , Bassett Danielle S. 
Published: May 2020

AbstractHumans are adept at uncovering abstract associations in the world around them, yet the underlying mechanisms remain poorly understood. Intuitively, learning the higher-order structure of statistical relationships should involve complex mental processes. Here we propose an alternative perspective: that higher-order associations instead arise from natural errors in learning and memory. Using the free energy principle, which bridges information theory and Bayesian inference, we derive a maximum entropy model of people’s internal representations of the transitions between stimuli. Importantly, our model (i) affords a concise analytic form, (ii) qualitatively explains the effects of transition network structure on human expectations, and (iii) quantitatively predicts human reaction times in probabilistic sequential motor tasks. Together, these results suggest that mental errors influence our abstract representations of the world in significant and predictable ways, with direct implications for the study and design of optimally learnable information sources.
Epitaxial bulk acoustic wave resonators as highly coherent multi-phonon sources for quantum acoustodynamics
Authors: Gokhale Vikrant J. , Downey Brian P. , Katzer D. Scott , Nepal Neeraj , Lang Andrew C. , Stroud Rhonda M. , Meyer David J. 
Published: May 2020

AbstractSolid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. However, scattering from defects, grain boundaries, and interfacial/surface roughness in the composite transducer severely limits the phonon relaxation time in sputter-deposited devices. Here, we grow an epitaxial-HBAR, consisting of a metallic NbN bottom electrode and a piezoelectric GaN film on a SiC substrate. The acoustic impedance-matched epi-HBAR has a power injection efficiency >99% from transducer to phonon cavity. The smooth interfaces and low defect density reduce phonon losses, yielding (f × Q) and phonon lifetimes up to 1.36 × 1017 Hz and 500 µs respectively. The GaN/NbN/SiC epi-HBAR is an electrically actuated, multi-mode phonon source that can be directly interfaced with NbN-based superconducting qubits or SiC-based spin qubits.
Atomic-like charge qubit in a carbon nanotube enabling electric and magnetic field nano-sensing
Authors: Khivrich I. , Ilani S. 
Published: May 2020

AbstractQuantum sensing techniques have been successful in pushing the sensitivity limits in numerous fields, and hold promise for scanning probes that study nano-scale devices and materials. However, forming a nano-scale qubit that is simple and robust enough to be placed on a scanning tip, and sensitive enough to detect various physical observables, is still a great challenge. Here, we demonstrate, in a carbon nanotube, an implementation of a charge qubit that achieves these requirements. Our qubit’s basis states are formed from the natural electronic wavefunctions in a single quantum dot. Different magnetic moments and charge distributions of these wavefunctions make it sensitive to magnetic and electric fields, while difference in their electrical transport allows a simple transport-based readout mechanism. We demonstrate electric field sensitivity better than that of a single electron transistor, and DC magnetic field sensitivity comparable to that of NV centers. Due to its simplicity, this qubit can be fabricated using conventional techniques. These features make this atomic-like qubit a powerful tool, enabling a variety of imaging experiments.
Nucleation-controlled growth of superior lead-free perovskite Cs3Bi2I9 single-crystals for high-performance X-ray detection
Authors: Zhang Yunxia , Liu Yucheng , Xu Zhuo , Ye Haochen , Yang Zhou , You Jiaxue , Liu Ming , He Yihui , Kanatzidis Mercouri G. , Liu Shengzhong 
Published: May 2020

AbstractThe organic-inorganic hybrid lead halide perovskites have emerged as a series of star materials for solar cells, lasers and detectors. However, the issues raised by the toxic lead element and marginal stability due to the volatile organic components have severely limited their potential applications. In this work, we develop a nucleation-controlled solution method to grow large size high-quality Cs3Bi2I9 perovskite single crystals (PSCs). Using the technique, we harvest some centimeter-sized single crystals and achieved high device performance. We find that X-ray detectors based on PSCs exhibit high sensitivity of 1652.3 μC Gyair−1 cm−2 and very low detectable dose rate of 130 nGyair s−1, both desired in medical diagnostics. In addition, its outstanding thermal stability inspires us to develop a high temperature X-ray detector with stable response at up to 100 °C. Furthermore, PSCs exhibit high X-ray imaging capability thanks to its negligible signal drifting and extremely high stability.
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
Authors: Kim Jung-Min , Yang Yeon-Suk , Park Kwang Hwan , Ge Xianpeng , Xu Ren , Li Na , Song Minkyung , Chun Hyunho , Bok Seoyeon , Charles Julia F. , Filhol-Cochet Odile , Boldyreff Brigitte , Dinter Teresa , Yu Paul B. , Kon Ning , Gu Wei , Takarada Takeshi , Greenblatt Matthew B. , Shim Jae-Hyuck 
Published: May 2020

AbstractThe osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues. RUNX2 is essential for tuning this balance, but the mechanisms of posttranslational control of RUNX2 remain to be fully elucidated. Here, we identify that a CK2/HAUSP pathway is a key regulator of RUNX2 stability, as Casein kinase 2 (CK2) phosphorylates RUNX2, recruiting the deubiquitinase herpesvirus-associated ubiquitin-specific protease (HAUSP), which stabilizes RUNX2 by diverting it away from ubiquitin-dependent proteasomal degradation. This pathway is important for both the commitment of SSCs to osteoprogenitors and their subsequent maturation. This CK2/HAUSP/RUNX2 pathway is also necessary for HO, as its inhibition blocked HO in multiple models. Collectively, active deubiquitination of RUNX2 is required for bone formation and this CK2/HAUSP deubiquitination pathway offers therapeutic opportunities for disorders of inappropriate mineralization.
p85β regulates autophagic degradation of AXL to activate oncogenic signaling
Authors: Rao Ling , Mak Victor C. Y. , Zhou Yuan , Zhang Dong , Li Xinran , Fung Chloe C. Y. , Sharma Rakesh , Gu Chao , Lu Yiling , Tipoe George L. , Cheung Annie N. Y. , Mills Gordon B. , Cheung Lydia W. T. 
Published: May 2020

AbstractPIK3R2 encodes the p85β regulatory subunit of phosphatidylinositol 3-kinase and is frequently amplified in cancers. The signaling mechanism and therapeutic implication of p85β are poorly understood. Here we report that p85β upregulates the protein level of the receptor tyrosine kinase AXL to induce oncogenic signaling in ovarian cancer. p85β activates p110 activity and AKT-independent PDK1/SGK3 signaling to promote tumorigenic phenotypes, which are all abolished upon inhibition of AXL. At the molecular level, p85β alters the phosphorylation of TRIM2 (an E3 ligase) and optineurin (an autophagy receptor), which mediate the selective regulation of AXL by p85β, thereby disrupting the autophagic degradation of the AXL protein. Therapeutically, p85β expression renders ovarian cancer cells vulnerable to inhibitors of AXL, p110, or PDK1. Conversely, p85β-depleted cells are less sensitive to these inhibitors. Together, our findings provide a rationale for pharmacological blockade of the AXL signaling axis in PIK3R2-amplified ovarian cancer.
Evolution of cooperation on temporal networks
Authors: Li Aming , Zhou Lei , Su Qi , Cornelius Sean P. , Liu Yang-Yu , Wang Long , Levin Simon A. 
Published: May 2020

AbstractPopulation structure is a key determinant in fostering cooperation among naturally self-interested individuals in microbial populations, social insect groups, and human societies. Traditional research has focused on static structures, and yet most real interactions are finite in duration and changing in time, forming a temporal network. This raises the question of whether cooperation can emerge and persist despite an intrinsically fragmented population structure. Here we develop a framework to study the evolution of cooperation on temporal networks. Surprisingly, we find that network temporality actually enhances the evolution of cooperation relative to comparable static networks, despite the fact that bursty interaction patterns generally impede cooperation. We resolve this tension by proposing a measure to quantify the amount of temporality in a network, revealing an intermediate level that maximally boosts cooperation. Our results open a new avenue for investigating the evolution of cooperation and other emergent behaviours in more realistic structured populations.
Backmapping triangulated surfaces to coarse-grained membrane models
Authors: Pezeshkian Weria , König Melanie , Wassenaar Tsjerk A. , Marrink Siewert J. 
Published: May 2020

AbstractMany biological processes involve large-scale changes in membrane shape. Computer simulations of these processes are challenging since they occur across a wide range of spatiotemporal scales that cannot be investigated in full by any single current simulation technique. A potential solution is to combine different levels of resolution through a multiscale scheme. Here, we present a multiscale algorithm that backmaps a continuum membrane model represented as a dynamically triangulated surface (DTS) to its corresponding molecular model based on the coarse-grained (CG) Martini force field. Thus, we can use DTS simulations to equilibrate slow large-scale membrane conformational changes and then explore the local properties at CG resolution. We demonstrate the power of our method by backmapping a vesicular bud induced by binding of Shiga toxin and by transforming the membranes of an entire mitochondrion to near-atomic resolution. Our approach opens the way to whole cell simulations at molecular detail.
Multilayer hazes over Saturn’s hexagon from Cassini ISS limb images
Authors: Sánchez-Lavega A. , García-Muñoz A. , del Río-Gaztelurrutia T. , Pérez-Hoyos S. , Sanz-Requena J. F. , Hueso R. , Guerlet S. , Peralta J. 
Published: May 2020

AbstractIn June 2015, Cassini high-resolution images of Saturn’s limb southwards of the planet’s hexagonal wave revealed a system of at least six stacked haze layers above the upper cloud deck. Here, we characterize those haze layers and discuss their nature. Vertical thickness of layers ranged from 7 to 18 km, and they extended in altitude ∼130 km, from pressure level 0.5 bar to 0.01 bar. Above them, a thin but extended aerosol layer reached altitude ∼340 km (0.4 mbar). Radiative transfer modeling of spectral reflectivity shows that haze properties are consistent with particles of diameter 0.07–1.4 μm and number density 100–500 cm−3. The nature of the hazes is compatible with their formation by condensation of hydrocarbon ices, including acetylene and benzene at higher altitudes. Their vertical distribution could be due to upward propagating gravity waves generated by dynamical forcing by the hexagon and its associated eastward jet.
Valence-programmable nanoparticle architectures
Authors: Sun Sha , Yang Shize , Xin Huolin L. , Nykypanchuk Dmytro , Liu Mingzhao , Zhang Honghu , Gang Oleg 
Published: May 2020

AbstractNanoparticle-based clusters permit the harvesting of collective and emergent properties, with applications ranging from optics and sensing to information processing and catalysis. However, existing approaches to create such architectures are typically system-specific, which limits designability and fabrication. Our work addresses this challenge by demonstrating that cluster architectures can be rationally formed using components with programmable valence. We realize cluster assemblies by employing a three-dimensional (3D) DNA meshframe with high spatial symmetry as a site-programmable scaffold, which can be prescribed with desired valence modes and affinity types. Thus, this meshframe serves as a versatile platform for coordination of nanoparticles into desired cluster architectures. Using the same underlying frame, we show the realization of a variety of preprogrammed designed valence modes, which allows for assembling 3D clusters with complex architectures. The structures of assembled 3D clusters are verified by electron microcopy imaging, cryo-EM tomography and in-situ X-ray scattering methods. We also find a close agreement between structural and optical properties of designed chiral architectures.
Bioorthogonal non-canonical amino acid tagging reveals translationally active subpopulations of the cystic fibrosis lung microbiota
Authors: Valentini Talia D. , Lucas Sarah K. , Binder Kelsey A. , Cameron Lydia C. , Motl Jason A. , Dunitz Jordan M. , Hunter Ryan C. 
Published: May 2020

AbstractCulture-independent studies of cystic fibrosis lung microbiota have provided few mechanistic insights into the polymicrobial basis of disease. Deciphering the specific contributions of individual taxa to CF pathogenesis requires comprehensive understanding of their ecophysiology at the site of infection. We hypothesize that only a subset of CF microbiota are translationally active and that these activities vary between subjects. Here, we apply bioorthogonal non-canonical amino acid tagging (BONCAT) to visualize and quantify bacterial translational activity in expectorated sputum. We report that the percentage of BONCAT-labeled (i.e. active) bacterial cells varies substantially between subjects (6-56%). We use fluorescence-activated cell sorting (FACS) and genomic sequencing to assign taxonomy to BONCAT-labeled cells. While many abundant taxa are indeed active, most bacterial species detected by conventional molecular profiling show a mixed population of both BONCAT-labeled and unlabeled cells, suggesting heterogeneous growth rates in sputum. Differentiating translationally active subpopulations adds to our evolving understanding of CF lung disease and may help guide antibiotic therapies targeting bacteria most likely to be susceptible.
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
Authors: Kim Nayoung , Kim Hong Kwan , Lee Kyungjong , Hong Yourae , Cho Jong Ho , Choi Jung Won , Lee Jung-Il , Suh Yeon-Lim , Ku Bo Mi , Eum Hye Hyeon , Choi Soyean , Choi Yoon-La , Joung Je-Gun , Park Woong-Yang , Jung Hyun Ae , Sun Jong-Mu , Lee Se-Hoon , Ahn Jin Seok , Park Keunchil , Ahn Myung-Ju , Lee Hae-Ock 
Published: May 2020

AbstractAdvanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most prevalent histological lung cancer type diagnosed at stage IV in over 40% of all cases. From 208,506 cells populating the normal tissues or early to metastatic stage cancer in 44 patients, we identify a cancer cell subtype deviating from the normal differentiation trajectory and dominating the metastatic stage. In all stages, the stromal and immune cell dynamics reveal ontological and functional changes that create a pro-tumoral and immunosuppressive microenvironment. Normal resident myeloid cell populations are gradually replaced with monocyte-derived macrophages and dendritic cells, along with T-cell exhaustion. This extensive single-cell analysis enhances our understanding of molecular and cellular dynamics in metastatic lung cancer and reveals potential diagnostic and therapeutic targets in cancer-microenvironment interactions.
A limbic circuitry involved in emotional stress-induced grooming
Authors: Mu Ming-Dao , Geng Hong-Yan , Rong Kang-Lin , Peng Rong-Chao , Wang Shu-Ting , Geng Lin-Ting , Qian Zhong-Ming , Yung Wing-Ho , Ke Ya 
Published: May 2020

AbstractProlonged exposure to negative stressors could be harmful if a subject cannot respond appropriately. Strategies evolved to respond to stress, including repetitive displacement behaviours, are important in maintaining behavioural homoeostasis. In rodents, self-grooming is a frequently observed repetitive behaviour believed to contribute to post-stress de-arousal with adaptive value. Here we identified a rat limbic di-synaptic circuit that regulates stress-induced self-grooming with positive affective valence. This circuit links hippocampal ventral subiculum to ventral lateral septum (LSv) and then lateral hypothalamus tuberal nucleus. Optogenetic activation of this circuit triggers delayed but robust excessive grooming with patterns closely resembling those evoked by emotional stress. Consistently, the neural activity of LSv reaches a peak before emotional stress-induced grooming while inhibition of this circuit significantly suppresses grooming triggered by emotional stress. Our results uncover a previously unknown limbic circuitry involved in regulating stress-induced self-grooming and pinpoint a critical role of LSv in this ethologically important behaviour.