bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follicular fluid steroid profile in sows: relationship to follicle size and oocyte quality†
Authors: Costermans N G J , Soede N M , van Tricht F , Blokland M , Kemp B , Keijer J , Teerds K J 
Published: December 2019

AbstractIdentification of reliable characteristics of follicle quality and developmental competence has been pursued in numerous studies, but with inconsistent outcomes. Here, we aimed to identify these characteristics by analysis of the follicular fluid (FF) steroid profile in relation to cumulus-oocyte complex (COC) morphology and follicle size, followed by molecular substantiation. Multiparous sows at weaning were used to facilitate analysis at the start of the follicular phase of the oestrus cycle. Sows with a higher average follicle size (≥5 mm vs. &lt; 5 mm) had a higher follicular fluid β-estradiol concentration, but did not differ in other measured steroids. Sows with high compared to low percentage high-quality COCs (&lt;70% vs. ≥70% high-quality) had follicular fluid with a higher concentration of β-estradiol, 19-norandrostenedione, progesterone, and α-testosterone, while the concentration of cortisol was lower. Transcriptome analysis of granulosa cells of healthy follicles of sows with a high percentage high-quality COCs showed higher abundance of transcripts involved in ovarian steroidogenesis (e.g., CYP19A2 and 3, POR, VEGFA) and growth (IGF1) and differential abundance of transcripts involved in granulosa cell apoptosis (e.g., GADD45A, INHBB). Differences in aromatase transcript abundance (CYP19A1, 2 and 3) were confirmed at the protein level. In addition, sows with a high percentage high-quality COCs lost less weight during lactation and had higher plasma IGF1 concentration at weaning, which may have affected COC quality. To the best of our knowledge, this study is also the first to report the relation between FF steroid profile and COC quality.
Condylar changes in patients with idiopathic condylar resorption: retrospective 2-year follow-up CBCT-based case–control study
Authors: Exposto Cristina R , Stoustrup Peter , Kristensen Kasper D , Dalstra Michel , Pedersen Thomas K 
Published: December 2019

SummaryObjectivesTo compare condylar development and changes in condylar radiological appearance in patients with idiopathic condylar resorption (ICR) to a healthy, age- and gender matched, control group.Materials and methodsThis case-control study included 16 ICR patients [mean age: 15years, 9 months; standard deviation (SD): 4 years) and 16 controls (mean age: 16 years, 8 months; SD: 4 years, 7 months), with diagnostic (T0) and 2-year follow-up (T1) CBCT examinations. Condylar changes were evaluated through changes in condylar neck angle (CNA), and the transversal, vertical and anteroposterior displacement of five condylar points between T0 and T1. The magnitude and direction of condylar changes were evaluated using vector analyses. A qualitative radiological evaluation of the TMJ was performed based on healthy, erosive and repaired morphological appearance. Linear and angular measurements were assessed using ANOVA and a Tukey post-hoc test, and vectors were tested using an independent-sample 2-tailed t-test. Fisher’s exact test was used for the qualitative evaluation.ResultsAt T0, ICR patients exhibited decreased condylar height, smaller condylar width and posteriorly inclined CNA compared with the control group (P &lt; 0.05). During observation, condylar vertical growth was smaller in the ICR group than in the control group (P &lt; 0.05). Vector analysis showed an upward direction of vertical displacement for all condylar points in the control group; the ICR group showed a downward direction (P &lt; 0.003). The radiological appearance of 75% of the ICR condyles and 94% of the control condyles did not change during the 2-year follow-up period.ConclusionsICR condyles displayed reduced vertical development compared with control condyles. The radiological appearance remained unchanged for most joints. Observed changes in radiological appearance did not always follow a progressive model of degenerative joint disease.
Low and elevated B-type natriuretic peptide levels are associated with increased mortality in patients with preserved ejection fraction undergoing transcatheter aortic valve replacement: an analysis of the PARTNER II trial and registry
Authors: Chen Shmuel , Redfors Bjorn , O’Neill Brian P , Clavel Marie-Annick , Pibarot Philippe , Elmariah Sammy , Nazif Tamim , Crowley Aaron , Ben-Yehuda Ori , Finn Matthew T , Alu Maria C , Vahl Torsten P , Kodali Susheel , Leon Martin B , Lindman Brian R 
Published: December 2019

Abstract

Aims
B-type natriuretic peptide (BNP) is a cardiac neurohormone that is secreted in response to ventricular volume expansion and pressure overload. There are conflicting data regarding the association between BNP levels and outcomes after transcatheter aortic valve replacement (TAVR). We therefore sought to assess the association between baseline BNP and adverse outcomes in patients with symptomatic, severe aortic stenosis (AS), and left ventricular ejection fraction (LVEF) ≥50%, undergoing TAVR in the PARTNER 2 Trial and Registry.

Methods and results
A total of 1782 patients were included in the analysis, and BNP was evaluated both as a continuous log-transformed value and by a priori categories: low (&lt;50 pg/mL), normal (≥50 and &lt;100 pg/mL), moderately elevated (≥100 and &lt;400 pg/mL), or markedly elevated (≥400 pg/mL). Clinical outcomes from discharge to 2 years were compared between patients according to their baseline BNP level, using Kaplan–Meier event rates and multivariable Cox proportional hazards regression models. After adjustment, spline curves revealed a non-linear association between log-transformed BNP and all-cause and cardiovascular mortality in which both the lowest and highest values were associated with increased mortality. Two-year all-cause mortality rates for those with low (n = 86), normal (n = 202), moderately elevated (n = 885), and markedly elevated (n = 609) baseline BNP were 20.0%, 9.8%, 17.7%, and 26.1%, respectively. In adjusted models, compared to a normal baseline BNP, low [adjusted hazard ratio (HR) 2.6, 95% confidence interval (CI) 1.3–5.0, P-value 0.005], moderately elevated (adjusted HR 1.6, 95% CI 1.0–2.6, P-value 0.06), and markedly elevated (adjusted HR 2.1, 95% CI 1.3–3.5, P-value 0.003) BNP were associated with increased all-cause mortality, driven by cardiovascular mortality.

Conclusions
In a large cohort of patients with severe symptomatic AS and preserved LVEF undergoing TAVR, all-cause and cardiovascular mortality rates at 2 years were higher in patients with low and markedly elevated BNP levels.

Clinical Trial Registration
https://clinicaltrials.gov/ unique identifier #NCT01314313, #NCT02184442, #NCT03222128, and #NCT03222141.
Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome
Authors: Haider Ahmed , Bengs Susan , Luu Judy , Osto Elena , Siller-Matula Jolanta M , Muka Taulant , Gebhard Catherine 
Published: December 2019

Abstract
Although health disparities in women presenting with acute coronary syndrome (ACS) have received growing attention in recent years, clinical outcomes from ACS are still worse for women than for men. Women continue to experience higher patient and system delays and receive less aggressive invasive treatment and pharmacotherapies. Gender- and sex-specific variables that contribute to ACS vulnerability remain largely unknown. Notwithstanding the sex differences in baseline coronary anatomy and function, women and men are treated the same based on guidelines that were established from experimental and clinical trial data over-representing the male population. Importantly, younger women have a particularly unfavourable prognosis and a plethora of unanswered questions remains in this younger population. The present review summarizes contemporary evidence for gender and sex differences in vascular biology, clinical presentation, and outcomes of ACS. We further discuss potential mechanisms and non-traditional risk conditions modulating the course of disease in women and men, such as unrecognized psychosocial factors, sex-specific vascular and neural stress responses, and the potential impact of epigenetic modifications.
Influence of fault roughness on surface displacement: from numerical simulations to coseismic slip distributions
Authors: Bruhat Lucile , Klinger Yann , Vallage Amaury , Dunham Eric M 
Published: December 2019

SUMMARYField studies have characterized natural faults as rough, non-planar surfaces at all scales. Fault roughness induces local stress perturbations during slip, which dramatically affect rupture behaviour, resulting in slip heterogeneity. However, the relation between fault roughness and slip heterogeneity remains a key knowledge gap between current numerical and field studies. In this study, we analyse numerical simulations of earthquake rupture to determine how roughness influences final slip. Using a rupture catalogue containing thousands of dynamic rupture simulations on band-limited self-similar fractal fault profiles with varying roughness and background shear stress levels, we quantify how fault roughness affects the spectral characteristics of the resulting slip distribution. We find that slip distributions become increasingly more self-affine, that is, containing more short wavelength fluctuations as compared to the self-similar fault profiles, as roughness increases. We also find that, at very short wavelengths (&lt;1 km), the fractal dimension of the slip distributions dramatically changes with increasing roughness, background shear stress, and rupture speed (sub-Rayleigh versus supershear). The existence of a critical wavelength around 1 km, under which more short wavelengths are either preserved or created, suggests the role of rupture process and dynamic effects, together with fault geometry, in controlling the final slip distributions. The same spectral analysis is performed on high-resolution coseismic surface slip distributions from a catalogue of real strike-slip earthquakes. Compared to numerical simulations, all earthquakes feature slip distributions that are much more self-affine than the slip distributions from numerical simulations. A different critical wavelength, here around 5–6 km, appears, potentially informing about a critical asperity length. While we show here that the relation between fault roughness and slip is much more complex than expected, this study is a first attempt at using statistical analyses of numerical simulations on rough faults to investigate observed coseismic slip distributions.
“Battling” for Legitimacy: Analyzing Performative Contests in the Gaza Flotilla Paradigmatic Case
Authors: Wajner Daniel F 
Published: December 2019

AbstractHow can we explain the dynamics of nonconventional struggles such as the Gaza flotilla case of May 2010? Most international relations scholars analyze international disputes using a “chess logic,” according to which the actors seek to outmaneuver their opponents on the battleground. However, an increasing number of clashes are guided by a “performance logic”: although the players interact with one another, their real targets are audiences. The present study aims to bridge this gap, proposing a phenomenological framework for analyzing this particular kind of performative contest over legitimation and delegitimation in contemporary conflicts. It expands upon the idea that current anarchical global politics increasingly lead contending actors to engage in “pure” legitimation struggles—“battles for legitimacy”—seeking to persuade international audiences that they deserve political support. After providing guidelines for the identification of these phenomena, this article presents a model for the methodical examination of their interactive dynamics based on three legitimation functions (appropriateness, consensus, empathy). This model is applied to the flotilla case by mapping the protagonists’ framing contests across “legitimation (battle)fields.” The findings of this study, which emphasize the strong interplay between normative, political, and emotional mechanisms for empowering (de)legitimation strategies, can contribute to expanding the research program concerning international legitimacy.
The Long-Term Effects of Long Terms – Compulsory Schooling Reforms in Sweden
Authors: Fischer Martin , Karlsson Martin , Nilsson Therese , Schwarz Nina 
Published: December 2019

AbstractWe evaluate the impact on earnings, pensions, and further labor market outcomes of two parallel educational reforms increasing instructional time in Swedish primary school. The reforms extended the annual term length and years of compulsory schooling by comparable amounts. We find striking differences in the effects of the two reforms: at 5% the returns to the term length extension were sizeable and benefited broad ranges of the population. The compulsory schooling extension had small (2%) albeit significant effects, which were possibly driven by an increase in post-compulsory schooling. Both reforms led to increased sorting into occupations with heavy reliance on basic skills and the term extension reduced the gender gap in employment and earnings.
Reversal of Resistance to the Larvicide Temephos in an Aedes aegypti (Diptera: Culicidae) Laboratory Strain From Cuba
Authors: Bisset Juan A , Rodríguez María M , Piedra Luis A , Cruz Modesto , Gutiérrez Gladys , Ruiz Armando 
Published: December 2019

AbstractThe objective of this investigation was to know whether the organophosphate temephos resistance developed in larvae from a laboratory strain of Aedes aegypti (Linnaeus, 1762) from Cuba could be reversed. The resistant laboratory strain of Ae. aegypti, named SAN-F6, was left without temephos selection pressure for 12 generations. The level of temephos resistance was determined using WHO bioassays and mechanisms of metabolic resistance were determined based on enzyme activity levels detected by biochemical assays. Bioassays and biochemical assays were conducted on the SAN-F6 parental strain and every three reversal generations (SANRevF3, SANRevF6, SANRevF9, and SANRevF12) without temephos selection pressure. After 19 yr of keeping the SAN-F6 strain under selection pressure with the LC90 of temephos, the resistance ratio (RR50) was 47.5×. Biochemical assays indicated that esterase and glutathione S-transferase are still responsible for temephos resistance in this strain, but not mixed-function oxidase. Experiments on resistance reversal showed that temephos susceptibility could be recovered as α esterase activity levels decreased. The SAN-F6 strain has provided an essential basis for studies of temephos resistance in Cuba. It was demonstrated that the resistance developed to the larvicide temephos in Ae. aegypti from this Cuban lab strain is a reversible phenomenon, which suggests that similar outcomes might be expected in field populations. As such, the use of temephos alternated with other larvicides recommended by WHO such as Bti or pyriproxyfen is recommended to maintain the effectiveness of temephos and to achieve more effective control of Ae. aegypti.
Immunosuppressant-induced late acute pancreatitis after laparoscopic sleeve gastrectomy: a case report and literature review
Authors: AlQahtani Awadh , Alali Mohammed N , Allehiani Safaa 
Published: December 2019

Abstract
Acute pancreatitis (AP) is a serious life-threatening condition, especially in high-risk patients. Limited data exist regarding early and late complications of immunosuppressant drugs as a cause of pancreatitis, especially Tacrolimus and Mycophenolate Mofetil (MMF), after transplantation. We report a rare case of late AP secondary to immunosuppressants’ synergistic effect after 5 years of renal transplant in an obese patient on day 4 after laparoscopic sleeve gastrectomy (LSG). We present a 41-year-old Saudi obese male patient, known to have multiple comorbidities and a renal transplantation twice, was on multiple medications, including Prednisolone, MMF and Tacrolimus for 5 years. On day 4 post-LSG, he developed severe epigastric abdominal pain and was diagnosed to have AP as a late complication of immunosuppressants’ synergistic effect. LSG is a common safe procedure, but complications related to medical illnesses or medications can occur. Careful review and sufficient knowledge of early and late complications are required.
Discovery of a soft X-ray lag in the ultraluminous X-ray source NGC 1313 X-1
Authors: Kara E , Pinto C , Walton D J , Alston W N , Bachetti M , Barret D , Brightman M , Canizares C R , Earnshaw H P , Fabian A C , Fürst F , Kosec P , Middleton M J , Roberts T P , Soria R , Tao L , Webb N A 
Published: December 2019

ABSTRACT
Ultraluminous X-ray sources (ULXs) provide a unique opportunity to probe the geometry and energetics of super-Eddington accretion. The radiative processes involved in super-Eddington accretion are not well understood, and so studying correlated variability between different energy bands can provide insights into the causal connection between different emitting regions. We present a spectral-timing analysis of NGC 1313 X-1 from a recent XMM–Newton campaign. The spectra can be decomposed into two thermal-like components, the hotter of which may originate from the inner accretion disc, and the cooler from an optically thick outflow. We find correlated variability between hard (2–10 keV) and soft (0.3–2 keV) bands on kilosecond time-scales, and find a soft lag of ∼150 s. The covariance spectrum suggests that emission contributing to the lags is largely associated with the hotter of the two thermal-like components, likely originating from the inner accretion flow. This is only the third ULX to exhibit soft lags. The lags range over three orders of magnitude in amplitude, but all three are ∼5–20 per cent of the corresponding characteristic variability time-scales. If these soft lags can be understood in the context of a unified picture of ULXs, then lag time-scales may provide constraints on the density and extent of radiatively driven outflows.
A super-Earth and a mini-Neptune around Kepler-59
Authors: Saad-Olivera X , Martinez C F , Costa de Souza A , Roig F , Nesvorný D 
Published: December 2019

ABSTRACT
We characterize the radii and masses of the star and planets in the Kepler-59 system, as well as their orbital parameters. The star parameters are determined through a standard spectroscopic analysis, resulting in a mass of $1.359\pm 0.155\, \mathrm{M}_\odot$ and a radius of $1.367\pm 0.078\, \mathrm{R}_\odot$. The obtained planetary radii are $1.5\pm 0.1\, R_\oplus$ for the inner and $2.2\pm 0.1\, R_\oplus$ for the outer planet. The orbital parameters and the planetary masses are determined by the inversion of Transit Timing Variations (TTV) signals. We consider two different data sets: one provided by Holczer et al. (2016), with TTVs only for Kepler-59c, and the other provided by Rowe et al. (2015), with TTVs for both planets. The inversion method applies an algorithm of Bayesian inference (MultiNest) combined with an efficient N-body integrator (Swift). For each of the data set, we found two possible solutions, both having the same probability according to their corresponding Bayesian evidences. All four solutions appear to be indistinguishable within their 2-σ uncertainties. However, statistical analyses show that the solutions from Rowe et al. (2015) data set provide a better characterization. The first solution infers masses of $5.3_{-2.1}^{+4.0}~M_{\mathrm{\oplus }}$ and $4.6_{-2.0}^{+3.6}~M_{\mathrm{\oplus }}$ for the inner and outer planet, respectively, while the second solution gives masses of $3.0^{+0.8}_{-0.8}~M_{\mathrm{\oplus }}$ and $2.6^{+0.9}_{-0.8}~M_{\mathrm{\oplus }}$. These values point to a system with an inner super-Earth and an outer mini-Neptune. A dynamical study shows that the planets have almost co-planar orbits with small eccentricities (e &lt; 0.1), close to the 3:2 mean motion resonance. A stability analysis indicates that this configuration is stable over million years of evolution.
Discrimination of heavy elements originating from Pop III stars in z = 3 intergalactic medium
Authors: Kirihara Takanobu , Hasegawa Kenji , Umemura Masayuki , Mori Masao , Ishiyama Tomoaki 
Published: December 2019

ABSTRACT
We investigate the distribution of metals in the cosmological volume at $z$ ∼ 3, in particular, provided by massive Population III (Pop III) stars using a cosmological N-body simulation in which a model of Pop III star formation is implemented. Owing to the simulation, we can choose minihaloes where Pop III star formation occurs at $z$ &gt; 10 and obtain the spatial distribution of the metals at lower redshifts. To evaluate the amount of heavy elements provided by Pop III stars, we consider metal yield of pair-instability or core-collapse supernovae (SNe) explosions of massive stars. By comparing our results to the Illustris-1 simulation, we find that heavy elements provided by Pop III stars often dominate those from galaxies in low-density regions. The median value of the volume averaged metallicity is $Z\sim 10^{-4.5 - -2} \, \mathrm{Z}_{\odot }$ at the regions. Spectroscopic observations with the next generation telescopes are expected to detect the metals imprinted on quasar spectra.
Filaments and striations: anisotropies in observed, supersonic, highly magnetized turbulent clouds
Authors: Beattie James R , Federrath Christoph 
Published: December 2019

ABSTRACTStars form in highly magnetized, supersonic turbulent molecular clouds. Many of the tools and models that we use to carry out star formation studies rely upon the assumption of cloud isotropy. However, structures like high-density filaments in the presence of magnetic fields and magnetosonic striations introduce anisotropies into the cloud. In this study, we use the two-dimensional power spectrum to perform a systematic analysis of the anisotropies in the column density for a range of Alfvén Mach numbers ($\operatorname{\mathcal {M}_{\text{A}}}=0.1{\!-\!10}$) and turbulent Mach numbers ($\operatorname{\mathcal {M}}=2{\!-\!20}$), with 20 high-resolution, three-dimensional turbulent magnetohydrodynamic simulations. We find that for cases with a strong magnetic guide field, corresponding to $\operatorname{\mathcal {M}_{\text{A}}}\lt 1$, and $\operatorname{\mathcal {M}}\lesssim 4$, the anisotropy in the column density is dominated by thin striations aligned with the magnetic field, while for $\operatorname{\mathcal {M}}\gtrsim 4$ the anisotropy is significantly changed by high-density filaments that form perpendicular to the magnetic guide field. Indeed, the strength of the magnetic field controls the degree of anisotropy and whether or not any anisotropy is present, but it is the turbulent motions controlled by $\operatorname{\mathcal {M}}$ that determine which kind of anisotropy dominates the morphology of a cloud.
Disentangling cataclysmic variables in Gaia’s HR diagram
Authors: Abril Javier , Schmidtobreick Linda , Ederoclite Alessandro , López-Sanjuan Carlos 
Published: December 2019

ABSTRACT
Cataclysmic variables (CVs) are interacting binaries consisting of at least three components that control their colour and magnitude. Using Gaia, we here investigate the influence of the physical properties of these binaries on their position in the Hertzsprung–Russell (HR) diagram. The CVs are on average located between the main sequence and the white dwarf regime, the maximum density being at GBP − GRP ∼ 0.56 and Gabs ∼ 10.15. We find a trend of the orbital period with colour and absolute brightness: with decreasing period, the CVs become bluer and fainter. We also identify the location of the various CV subtypes in the HR diagram and discuss the possible location of detached CVs, going through the orbital period gap.