bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyketide Cyclizations for the Synthesis of Polyaromatics
Authors: Fäseke Vincent C. , Raps Felix C. , Sparr Christof 
Published: December 2019

AbstractThe folding and cyclization of poly‐β‐carbonyl chains controlled by the intricate enzymatic polyketide synthase machinery results in a remarkable diversity of aromatic natural products. Synthetic methods that allow for the preparation of highly reactive polyketide chains while governing their folding in ensuing cyclizations likewise lead to versatile divergent preparations of aromatic scaffolds valuable for numerous applications. Although biomimetic polyketide cyclizations have repeatedly been applied in the total synthesis of polyphenol natural products, their utility for the preparation of the broad range of polyaromatic architectures has yet to reach its full potential. This Minireview highlights some of the virtues of applying polyketide logic to the retrosynthetic analysis of polycyclic aromatic scaffolds, the increasing accessibility of precursors, and the potential of small‐molecule catalysts for controlling polyketide cyclizations to provide polyaromatic scaffolds.
A Factorial Design Approach for Hydrothermal Synthesis of Phase‐Pure AgInO2: A Parametric Optimization Study
Authors: Beatriceveena T. V. , Sree Rama Murthy A. , Murugesan S. , Prabhu E. , Gnanasekar K. I. 
Published: December 2019

AbstractOwing to a wide range of industrial applications and fundamental importance, delafossite compounds have gathered tremendous interest in research community. In this study, the formation of hexagonal nanoplates of AgInO2 mainly dominated by (00l) facets with no metallic Ag impurity, reported using a facile hydrothermal route at 180 °C using KOH as mineralizer by adopting a factorial design approach. Rietveld analysis of the powder XRD pattern and SAED confirms the rhombohedral system of AgInO2. FE‐SEM image shows a uniform hexagonal plate‐like morphology with an average width of about 300 nm and thickness of 70 nm. XPS and EDX analysis confirm potassium ion free AgInO2. A specific surface area of about 48.5 m2 g−1 is arrived from N2 adsorption studies. Temperature‐dependent AC impedance measurements revealed an activation energy of 0.24 eV/f.u. Further, TG‐DTA studies found that the compound is stable in air up to 595 °C.
Energietransfervermittelte intermolekulare Carboiminylierung von Alkenen durch den “Persistent Radical Effect”
Authors: Patra Tuhin , Bellotti Peter , Strieth‐Kalthoff Felix , Glorius Frank 
Published: December 2019

AbstractEine intermolekulare vicinale Zwei‐Komponenten‐Carboiminylierung von Alkenen wurde durch Energietransferkatalyse erreicht. Oximester von Alkylcarbonsäuren werden als bifunktionelle Reagenzien zur Erzeugung von Alkyl‐ und Iminylradikalen verwendet. Die Addition des Alkylradikals an ein Alken erzeugt dabei ein transientes Radikal, das anschließend selektive Radikal‐Radikal‐Kupplung mit dem persistenten Iminylradikal eingeht. Durch anschließende Hydrolyse des Imins ermöglicht diese Methode direkten Zugang zu primären aliphatischen Aminen sowie α‐Aminosäuren.
On the Products of Cholesterol Autoxidation in Phospholipid Bilayers and the Formation of Secosterols Derived Therefrom
Authors: Schaefer Emily L. , Zopyrus Nadia , Zielinski Zosia A. M. , Facey Glenn A. , Pratt Derek A. 
Published: December 2019

AbstractIn homogenous solution, cholesterol autoxidation leads to a mixture of epimers of 5 primary products, whose concentrations vary in the presence/absence of antioxidants, such as vitamin E. Two of the products (5α‐OOH and 6β‐OOH) undergo Hock fragmentation to yield electrophilic secosterols implicated in disease. Herein, we show that the product distribution is similar in phospholipid bilayers, in that the 7‐OOHs are the major products, but the presence/absence of vitamin E has no effect on the distribution. Cholesterol 7α‐OOH, but not 7β‐OOH, undergoes Hock fragmentation to yield a mixture of unprecedented A‐ring cleavage products and 6,7‐epoxides. When subjected to typical derivatization conditions, 7α‐OOH yields products with essentially indistinguishable chromatographic and spectroscopic features from the previously identified secosterols, casting further doubt on their controversial origin from endogenous O3.
Electrospinning of circumferentially aligned polymer nanofibers floating on rotating water collector
Authors: Li Shichen , Lee Bong‐Kee 
Published: December 2019

ABSTRACTThis work outlines a novel electrospinning process using a rotating water collector. The circumferentially aligned nanofibers are successfully fabricated using this process. The movement and conductivity of the liquid collector are considered as the two prime factors to investigate the interaction between electrospun nanofibers and liquid surface. Through the theoretical analysis of the movement of liquid collector, it is confirmed that the liquid flow velocity demonstrates a tendency to decline from the center of the vortex to the edge of the container. Experimental results show that as the fluid flow velocity increases, the alignment of the nanofibers increases as well. In addition, it is discovered that the conductivity of the water collector demonstrates no significant effect on the alignment of nanofibers. However, the solution with higher conductivity can produce a nanofiber mat with smaller dimension. The present study confirms the versatility of the liquid collector and can be used to prepare nanofiber mats with complicated structures. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48759.
Incidental capture and mortality of sea turtles in the industrial double‐rig‐bottom trawl fishery in south‐eastern Brazil
Authors: Tagliolatto Alicia Bertoloto , Giffoni Bruno , Guimarães Suzana , Godfrey Matthew H. , Monteiro‐Neto Cassiano 
Published: December 2019

Abstract

Incidental capture by fisheries is one of the principal threats to sea turtles. This study analysed spatial and temporal patterns of sea turtle bycatch, and estimated the direct initial mortality rate of these animals, in the industrial double‐rig‐bottom trawl fishery in south‐eastern Brazil. This is also the first attempt to relate bycatch/at‐sea mortality in bottom trawling to stranded turtles found along the adjacent coast.
The fishery was monitored from October 2015 to April 2018 through data collected voluntarily by the captains of eight industrial double‐rig trawlers. Two hundred and one sea turtles were captured during 9362 tows (43,657.52 trawling hours), resulting in a catch per unit effort (CPUE) of 0.0025 ± 0.0032 turtles h−1 with a standard net of 30.5 m headrope, with no significant difference between the estimated CPUEs for licensed shrimp and demersal fish trawlers.
Caretta caretta (52.24%) and Lepidochelys olivacea (38.81%) were the most frequently captured species. According to Generalized Linear Models, C. caretta bycatch was significantly higher during winter, at lower latitudes (−24° to −23°) and higher longitudes (−42° to −40°), while the L. olivacea bycatch was significantly higher at higher latitudes (−23° to −21°). The direct initial mortality rate of sea turtles in the shrimp trawlers was 7.65 ± 3.85%. However, none of the dead individuals subsequently released with plastic tags (n = 10) were found stranded on the coast. Mortality was not significantly related to the depth or duration of the trawling.
The results of this study suggest the need for improvements to the current management of the bottom trawl fishery in Brazil, moving from a species‐based to a spatial and seasonal‐based approach. There is also a need to develop turtle excluder devices adapted to local fishing conditions.
Recent Developments in Lead‐Free Double Perovskites: Structure, Doping, and Applications
Authors: Dave Kashyap , Fang Mu Huai , Bao Zhen , Fu Hong Ting , Liu Ru Shi 
Published: December 2019

AbstractLead‐free perovskite structures have been recently attracting considerable attention because of their eco‐friendly nature and properties, such as their lead‐based structure. In this work, we reviewed the lead‐free double perovskite (LFDP) structure because of its unique electronic dimensions, chemical stability, and substitutional chemistry compared with other lead‐free structures. We highlighted the recent progress on crystal structure prediction, synthesis methods, metal dopants, and ligand passivation on LFDPs. LFDPs are useful for several applications, such as solar cells, light‐emitting diodes, degradation of photocatalytic dyes, sensors, and X‐ray detectors. This report provides a summary of recent progress as a reference for further research on lead‐free perovskite structures.
The Self‐Construal Scale: A Potential Tool for Predicting Subjective Well‐Being of Individuals With Autism Spectrum Disorder
Authors: Kaneko Sachie , Kato Takahiro A. , Makinodan Manabu , Komori Takashi , Ishida Rio , Kishimoto Naoko , Takahashi Masato , Yasuda Yuka , Hashimoto Ryota , Iwasaka Hidemi , Tanaka Ayumi , Uchida Yukiko , Kanba Shigenobu , Kishimoto Toshifumi 
Published: December 2019

Despite accumulating evidence that culture shapes the symptoms of autism spectrum disorder (ASD), no studies have yet applied the Self‐Construal Scale to individuals with ASD. We compared the self‐construals (measured using the Self‐Construal Scale) of 31 high‐functioning Japanese individuals with ASD with those of 60 typically developing (TD) individuals. We also examined how the self‐construals of individuals with ASD related to their intelligence quotient, adverse childhood experiences, attention deficit hyperactivity disorder, ASD symptoms during adulthood and preschool years, and subjective well‐being. Individuals with ASD were more likely to display independent self‐construals than were TD individuals; unexpectedly, however, a substantial proportion of individuals with ASD (43.8%) displayed relatively interdependent self‐construals. Among individuals with ASD, self‐construals were significantly associated with ASD symptoms during preschool years, and with satisfaction of the need for autonomy and frustration of the need for relatedness. Evaluating self‐construals can help predict the subjective well‐being of high‐functioning individuals with ASD. Moreover, the Self‐Construal Scale may be useful for understanding the heterogeneous phenotypes of ASD, based on its association with autistic symptoms during preschool years, suggesting that the scale is a potential tool to develop efficient interventions for high‐functioning individuals with ASD. Autism Res 2020, 13: 947‐958. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryAutism Spectrum Disorders (ASD) are a group of disorders presenting a variety of symptoms and biological origins that can complicate choosing an intervention best suited for improving well‐being. Results indicate that a self‐construal scale could help understand individuals with high‐functioning ASD by independent and interdependent self‐construals that are associated with ASD symptoms during preschool years and adult subjective well‐being. Our findings suggest that this scale can help understand ASD and select appropriate interventions.
The Value of Survey‐Informed Communication Planning
Authors: Snyder Karen P. , Lamar Adriana P. , Campbell James 
Published: December 2019

Key TakeawaysSurvey research is a powerful tool to assess customers’ needs; using it effectively will depend on local conditions and your strategic plan.Early data collection can identify questions, concerns, or misperceptions and inform effective, targeted communication moving forward.Three water agency case studies offer approaches for community outreach to best inform communication planning.
Digital Twins: The Next Generation of Water Treatment Technology
Authors: Curl Jason M. , Nading Tyler , Hegger Kyle , Barhoumi Amer , Smoczynski Monika 
Published: December 2019

Key TakeawaysWater utilities are turning to “digital twins” to benefit their ongoing operations, improve planning, and enhance operator training.As facility “flight simulators,” digital twins allow utilities to quickly investigate many solutions without putting equipment, public health, or the environment at risk.Dynamic process simulations boost communication and collaboration, especially for teams with varied technical backgrounds.
Refinement of inducible gene deletion in embryos of pregnant mice
Authors: Savery Dawn , Maniou Eirini , Culshaw Lucy H. , Greene Nicholas D. E. , Copp Andrew J. , Galea Gabriel L. 
Published: December 2019

AbstractCreERT2‐mediated gene recombination is widely applied in developmental biology research. Activation of CreERT2 is typically achieved by injection of tamoxifen in an oily vehicle into the peritoneal cavity of mid‐gestation pregnant mice. This can be technically challenging and adversely impacts welfare. Here we characterize three refinements to this technique: Pipette feeding (not gavage) of tamoxifen, ex vivo CreERT2 activation in whole embryo culture and injection of cell‐permeable TAT‐Cre into Cre‐negative cultured embryos. We demonstrate that pipette feeding of tamoxifen solution to the mother on various days of gestation reliably activates embryonic CreERT2, illustrated here using β‐Actin
CreERT2, Sox2
CreERT2, T
CreERT2, and Nkx1.2
CreERT2. Pipette feeding of tamoxifen induces dose‐dependent recombination of Rosa26
mTmG reporters when administered at E8.5. Activation of two neuromesodermal progenitor‐targeting Cre drivers, T
CreERT2, and Nkx1.2
CreERT2, produces comparable neuroepithelial lineage tracing. Dose‐dependent CreERT2 activation can also be achieved by brief exposure to 4OH‐tamoxifen in whole embryo culture, allowing temporal control of gene deletion and eliminating the need to treat pregnant mice. Rosa26
mTmG reporter recombination can also be achieved regionally by injecting TAT‐Cre into embryonic tissues at the start of culture. This allows greater spatial control over Cre activation than can typically be achieved with endogenous CreERT2, for example by injecting TAT‐Cre on one side of the midline. We hope that our description and application of these techniques will stimulate refinement of experimental methods involving CreERT2 activation for gene deletion and lineage tracing studies. Improved temporal (ex vivo treatment) and spatial (TAT‐Cre injection) control of recombination will also allow previously intractable questions to be addressed.
Retracted: Protective impacts of circular RNA VMA21 on lipopolysaccharide‐engendered WI‐38 cells injury via mediating microRNA‐142‐3p
Authors: Yang Peili , Gao Ran , Zhou Wenwen , Han Anbang 
Published: December 2019

AbstractCircRNA derived from vacuolar ATPase assembly factor (circVMA21) is a newly‐researched circRNA, which is reported to adjust the degeneration of intervertebral disc. But, function of circVMA21 in infantile pneumonia is yet to be explored. The research surveyed the role of circVMA21 in lipopolysaccharide (LPS)‐caused WI‐38 cell inflammatory injury. LPS (10 μg/ml, 12 hr) was exploited to arouse WI‐38 cell inflammatory injury. Subsequently, the mediatory impacts of microRNA (miR)‐142‐3p and circVMA21 in LPS‐evoked cell injury were detected after transfection with the inhibited or overexpressed vectors. In above processes, cell behaviors of cell viability, apoptosis, and pro‐inflammatory factors were monitored. NF‐κB and JNK pathways were elucidated to showcase the feasible molecular mechanisms. Results displayed that LPS engendered WI‐38 cell inflammatory injury was alleviated as well as activated NF‐κB and JNK pathways was interdicted by miR‐142‐3p suppression. Importantly, restrained miR‐142‐3p expression was discovered in WI‐38 cells after overexpressing circVMA21. Moreover, overexpressed circVMA21 exerted the similar functions as miR‐142‐3p suppression in LPS‐triggered WI‐38 cell injury. But, the influence was clearly reversed by miR‐142‐3p overexpression. Hindered NF‐κB and JNK pathways caused by overexpressed circVMA21 was also crippled by miR‐142‐3p overexpression. The research discolsed that circVMA21 protected WI‐38 cells to resist LPS‐triggered inflammatory injury via miR‐142‐3p‐NF‐κB/JNK axis.
EBV status has prognostic implication among young patients with angioimmunoblastic T‐cell lymphoma
Authors: Eladl Ahmed E. , Shimada Kazuyuki , Suzuki Yuka , Takahara Taishi , Kato Seiichi , Kohno Kei , Elsayed Ahmed Ali , Wu Chun‐Chieh , Tokunaga Takashi , Kinoshita Tomohiro , Sakata‐Yanagimoto Mamiko , Nakamura Shigeo , Satou Akira 
Published: December 2019

AbstractEpstein‐Barr virus (EBV)‐positive B cells have been detected in 66%‐86% of patients with angioimmunoblastic T‐cell lymphoma (AITL). However, it remains controversial whether EBV status has an impact on the survival of patients with AITL. In this study, we aimed to reevaluate the impact of EBV on the clinicopathological characteristics of AITL. In particular, we focused on the impact of EBV in younger patients with AITL. In total, 270 cases of AITL were studied. Epstein‐Barr virus‐positive B cells were detected in 191 (71%) cases (EBER+ group). Among the patients who received anthracycline‐based therapy, the EBER status did not affect the overall survival (OS) or progression‐free survival (PFS). In the younger group of AITL (≤60 years), PFS was significantly worse in the EBER− group compared to the EBER+ group (P = .0013). Furthermore, the multivariate analysis identified EBER‐negative status, thrombocytopenia, and elevated serum IgA level as significant adverse prognostic factors for PFS (P < .001, P < .001, and P = .002). Based on these findings, we constructed new prognostic model for the younger group, based on three adverse factors. We classified the patients into two risk groups: low risk (no or 1 adverse factor) and high risk (2 or 3 adverse factors). This new model for younger patients with AITL showed that both OS and PFS were significantly related to the level of risk (P < .0001). In summary, this study showed that, among younger patients with AITL, an EBER+ status significantly improved prognosis compared to an EBER− status. Our new prognostic model should be applicable to younger patients with AITL.
The Development Process: from SAHA to Hydroxamate HDAC Inhibitors with Branched CAP Region and Linear Linker
Authors: Yang Feifei , Zhao Na , Hu Yunjie , Jiang Cheng‐Shi , Zhang Hua 
Published: December 2019

AbstractHistone deacetylases (HDACs) belong to a group of epigenetic regulatory enzymes that participate in modulating the acetylation level of histone lysine residues as well as non‐histone proteins, and they play a key role in the regulation of gene expression. HDACs are potential anticancer drug targets highly expressed in various kinds of cancer cells. So far, five small molecules targeting HDACs have been approved for the therapy of cancer, and over 20 inhibitors of HDACs are under different phases of clinical trials. Among them, hydroxamate‐based HDAC inhibitors (HDACis) represent a well‐investigated series of chemical entities. The current review covers the recent progress in the discovery process, form SAHA to hydroxamate HDAC inhibitors with branched CAP region and linear linker. At the same time, the pharmacological and structure‐activity relationship (SAR) studies of the specific derivatives from SAHA and the HDACis with branched CAP region and linear linker are also introduced.
A look inside stent deployment in hemodialysis patients
Authors: Saad Marwan , Abbott J. Dawn 
Published: December 2019

Key Points
In this observational study, optical coherence tomography (OCT) after percutaneous coronary intervention (PCI) showed higher rates of abnormal findings in hemodialysis compared with nonhemodialysis patients.
In this high‐risk population, the utilization of intracoronary imaging as well as appropriate lesion preparation should be adopted to optimize PCI results.
With the high resolution of OCT, identification of abnormal findings after PCI, such as small edge dissections, is common. Further research is encouraged to evaluate clinical outcomes associated with treating minor abnormal findings on OCT after PCI.
Outcomes of transfemoral balloon expandable transcatheter aortic valve implantation: Comparison of two subsequent valve generations
Authors: Schymik Gerhard , Wendler Olaf , Hengstenberg Christian , Ohlmann Patrick , Gilard Martine , Digne Franck , Souteyrand Geraud , Letocart Vincent , van Belle Eric , Bramlage Peter , Tarantini Giuseppe ,   SOURCE 3 and SOURCE XT Investigators
Published: December 2019

AbstractBackgroundThe SAPIEN 3 (S3) addresses several limitations of the SAPIEN XT (SXT) for the performance of transfemoral (TF‐) balloon expandable transcatheter aortic valve implantation (TAVI).ObjectivesWe aimed to determine whether their altered features translate into improved outcomes in a real‐world TF‐TAVI patient population.MethodsData for 3,314 patients were extracted from the European registries SOURCE‐XT and SOURCE‐3. Patients were propensity‐score (PS) matched (n= 1,169/group).ResultsIn the PS matched comparison, device success was higher in the S3 (99.2%) compared to the SXT group (98.2%;p= .04). S3 patients experienced a lower rate of procedural death (0.7 vs. 2.6%;p= .0004), moderate/severe paravalvular leakage (PVL; 1.4 vs. 5.5%;p < .0001), and procedure‐related stroke (1.2 vs. 2.4%;p= .04) while higher rates of mean aortic valve gradients ≥20 mmHg, and new permanent pacemaker implantations were seen. At 30 days a lower rate of all‐cause mortality was seen (2.1% vs. 4.3%;p= .003), which was preserved after 1 year (10.7% vs. 14.9%;p= .002). A Cox regression predicting 1‐year mortality resulted in a hazard ratio of 0.684 in favor of S3 (p= .0026). The same was true of stroke (2.8% vs. 5.7%;p= .0007), and moderate/severe PVL (2.7 vs. 7.3%;p= .0002) at 1 year. The rate of new pacemaker implantations (13.6% vs. 9.5%;p= .001) and NYHA III/IV (12.8 vs. 8.6%;p= .004) was higher with the S3.ConclusionsThe improved features of the S3 appear to translate into improved survival and reduced rates of adverse complications, with the exception of a higher rate of new pacemaker implantations.
Synergetic Catalysis for One‐pot Bis‐alkoxycarbonylation of Terminal Alkynes over Pd/Xantphos−Al(OTf)3 Bi‐functional Catalytic System
Authors: Guo Wen‐Di , Liu Lei , Yang Shu‐Qing , Chen Xiao‐Chao , Lu Yong , VO‐Thanh Giang , Liu Ye 
Published: December 2019

AbstractTandem bis‐alkoxycarbonylation of alkynes allows for the preparation of 2‐substituted succinates from alkynes and nucleophile alcohol via two successive alkoxycarbonylation with advantages of 100 % atomic economy and simplified one‐pot operation. Herein, the one‐pot tandem bis‐alkoxycarbonylation of alkynes was accomplished over the bi‐functional catalytic system containing Xantphos‐modified Pd‐complex and Lewis super‐acid of Al(OTf)3. It was found that, via the synergetic catalysis, the involved Xantphos‐modified Pd‐complex was responsible for the activation of CO and the alkynes through coordination to Pd‐center while Al(OTf)3 was in charge of the activation of the alcohol to facilitate the formation of [Pd−H]+ active species. The in situ high‐pressure FT‐IR analysis, coupled with 1H/13C NMR spectral characterizations, confirmed that the introduced Al(OTf)3 with intensive oxophilicity (via acid‐base pair interaction) was able to activate nucleophilic MeOH to be a reliable proton‐donor (i. e. hydride‐source) to warrant the formation and stability of [Pd−H]+ species upon the oxidation of Pd0 by H+ (Pd0+H+→[PdII−H]+). Over the developed bi‐functional catalytic system, the yields of the target diesters were obtained in the range of 36∼86 % in this sequence with the wide substrate scope.