bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: A Serial Follow‐Up Study by Computed Tomography‐Derived Fractional Flow Reserve
Authors: Yu Mengmeng , Dai Xu , Yu Lihua , Lu Zhigang , Shen Chengxing , Tao Xiaofeng , Zhang Jiayin 
Published: May 2020

Background
Whether statin treatment can improve hemodynamic status of coronary atherosclerotic plaque remains unknown. It is of clinical interest to explore the hemodynamic change of coronary lesions after statin treatment.

Methods and Results

Consecutive patients with intermediate pre‐test probability of coronary artery disease were prospectively enrolled and underwent baseline coronary computed tomography angiography (
CCTA
) as well as follow‐up
CCTA
. The primary end point was to determine the lesion‐specific change of △computed tomography‐derived fractional flow reserve (△
CT
‐
FFR
, defined as the change of
CT
‐
FFR
value across each lesion) after rosuvastatin treatment. The secondary end point was to compare the change of other plaque characteristics according to serial
CCTA
findings. 152 patients (mean age: 67.1±9.7 years, 100 men, mean follow‐up duration of 13.9±2.5 months) were finally included. In non‐calcified plaque subgroup, △
CT
‐
FFR
was significantly lower at follow‐up compared with baseline (0.051±0.010 versus 0.035±0.012,
P
=0.013). All other parameters were not found to be significantly different between baseline and follow‐up
CCTA
measurements. In calcified plaque and mixed plaque subgroups, all parameters showed no significant differences between baseline and follow‐up
CCTA
groups (
P
>0.05 for all). According to multivariate regression analysis, non‐calcified plaque was >2 times more likely than calcified plaque to observe the decrease of △
CT
‐
FFR
(adjusted hazard ratio: 2.05 [1.03–4.09],
P
=0.042).

Conclusions

In patients with mild to intermediate coronary stenosis, rosuvastatin treatment resulted in a reduction in lesion‐specific △
CT
‐
FFR
at mid‐term follow‐up. This hemodynamic improvement was mainly observed for non‐calcified lesions.
Tamar’s Desolation: a Visualization of Her Silent Presence Through Manchester by the Sea
Authors: Joo Samantha 
Published: May 2020

Abstract
Amnon brutally rapes his half-sister, Tamar, while Absalom, her full brother, is said to have silenced her. It is no wonder that she is desolated. However, commentators have provided two distinct interpretations in which she is either devastated by the rape or by the silencing. Since she is violated, she is disconsolate. Or in most feminist readings, Tamar is ravaged by the silencing after the event. While both readings are possible based on the different versions of the text, Tamar is never silenced. Instead, the reference to her desolation reflects the incarnation of the violation on her body; she expresses the event through her embattled body. This type of desolation is most visually demonstrated in the Academy Award winning screenplay, Manchester by the Sea, in which Lee Chandler, the main character embodies the unspeakable, the death of his three children. Both Lee and Tamar bear their stories in their silent presence.
Three Blind Vices?
Authors: Jones K.L. 
Published: May 2020

Abstract
Frequently Samson’s blindness is linked with newfound spiritual insight, with physical humiliation, and occasionally with instrumental talion. Few question the role of blindness in the text through other lenses or with knowledge of ancient theories of vision. Balancing this, I investigate Samson’s sight and blindness in the context of Judges 13-16, asking what his sensation and sensory impairment signified in the broader context of the Hebrew Bible (HB) and wider Ancient Near East (ANE).
Sexual association and cicadellid hosts of Dryinidae (Hymenoptera, Chrysidoidea): description of five new species from Brazil and a synopsis of the interaction with Gyponini (Hemiptera, Membracoidea)
Authors: Martins André Luis , Domahovski Alexandre Cruz , Rendón-Mera Diana Isabel 
Published: May 2020

Abstract
Interactions between dryinids and their hosts are poorly known in the Neotropical region, especially for the Brazilian fauna. This study aims to expand this incipient knowledge by describing a new species of Anteon Jurine and four new species of Gonatopus Ljungh reared from parasitized leafhoppers (Cicadellidae) collected in the state of Paraná, Southern Brazil. The new species, A. elianeae sp. nov., G. josei sp. nov., G. meloi sp. nov., G. pinhalensis sp. nov. and G. taquarensis sp. nov., are associated with leafhopper species of the subfamilies Iassinae (tribe Gyponini) and Deltocephalinae (tribes Deltocephalini and Pendarini). Both sexes of G. josei sp. nov. and G. taquarensis sp. nov. were associated and males are described, representing the first sexual association based on reared specimens from Brazil. We record for the first time species of Dryinidae parasitizing the leafhoppers species: Curtara concava, Gypona lita and Reticana lineatta (Gyponini), Graminella striatella (Deltocephalini) and Copidinomus vittulatus (Pendarini). All known records in the Neotropic of both Anteon and Gonatupus species associated with host are compiled, all known records of parasitoids of gyponines are reviewed, and the interactions with dryinids are discussed. Each new species is diagnosed and described, and illustrations of both dryinids and parasitized hosts are provided.
Facilitators and Barriers of Sleep in Young Adults With Type 1 Diabetes
Authors: Griggs Stephanie , Whittemore Robin , Redeker Nancy S. , Grey Margaret 
Published: May 2020

Purpose The purpose of this study was to explore the perceived facilitators and barriers for obtaining sufficient sleep in young adults with type 1 diabetes (T1D). Methods A qualitative descriptive approach was used to generate data. In-depth semi-structured interviews with 30 young adults with T1D (66.7% female, mean age = 22.1 years) were conducted. Interviews were transcribed verbatim and coded using NVivo. Results Young adults with T1D reported feeling challenged at bedtime and overnight by the demands of a complex disease management regimen. General and diabetes-specific barriers and facilitators to obtaining sufficient sleep were the overarching themes in the present study. Young adults perceived that electronic device use was a facilitator for relaxation before bed and a barrier to sleep by some participants. Delays in bedtime or disruptions in sleep were common diabetes-specific barriers. Conclusions When designing sleep-promoting interventions for young adults with T1D, researchers should consider diabetes-specific challenges and solutions in addition to those present in the general young adult population.
Quantitative T1 mapping of the substantia nigra using phase-sensitive inversion recovery sequence at 3.0-T: a healthy volunteer study
Authors: Fujiwara Yasuhiro , Hirai Tetsuyoshi , Ueda Tomohiro , Kumazoe Hiroyuki , Ito Shigeki 
Published: May 2020

Background Quantitative evaluation of degeneration of the substantia nigra (SN) is important for early, pre-symptomatic diagnosis of Parkinson’s disease (PD). Accordingly, a clinically feasible imaging and quantification technique are needed. Purpose To investigate the T1 value of the SN in healthy individuals from phase-sensitive inversion recovery (PSIR) images and to clarify its correlation with the SN characteristics on neuromelanin (NM) images to identify an imaging biomarker for early diagnosis of PD. Material and Methods T1-weighted and NM images of the SN from 32 healthy volunteers were obtained using PSIR and turbo spin-echo sequences. The contrast between the SN and cerebral peduncle (CP) and area of the SN were measured; the T1 values of the SN from PSIR images and relationships between the T1 value and age/SN area were evaluated. Results There was a significant negative correlation between age and the SN area obtained using PSIR imaging. The SN area on PSIR images (104.9 ± 20.9 mm2) was significantly larger than that on NM images (72.1 ± 14.9 mm2). There was a significant negative correlation between the SN area and the T1 value of the SN obtained from PSIR images. Conclusion In healthy adults, the area and T1 value of the SN measured on PSIR images were different from those obtained from NM images. This suggests that PSIR imaging may help in the assessment of SN degeneration.
Analysis of Risk Factors for Ramp Lesions Associated With Anterior Cruciate Ligament Injury
Authors: Kim Seong Hwan , Seo Hyun Je , Seo Dong Won , Kim Kang-Il , Lee Sang Hak 
Published: May 2020

Background: The incidence of meniscocapsular junction tears of the medial meniscus posterior horn, known as ramp lesions, is reported to be 9.3% to 23.9%. However, these lesions are not consistently diagnosed with routine arthroscopic exploration and magnetic resonance imaging (MRI). Purpose: To determine risk factors associated with ramp lesions in anterior cruciate ligament–injured knees. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 275 patients undergoing anterior cruciate ligament reconstruction between June 2011 and March 2019 were included in this study. Exclusion criteria were revisions, fracture histories, and multiple-ligament injuries other than medial collateral ligament injury. Patients were divided into 2 groups, those with and without ramp lesions according to arthroscopic diagnosis. Binary logistic regression was used to analyze risk factors: age, sex, body mass index, time from injury to surgery (<3 or ≥3 months), mechanism of injury (contact/noncontact), Segond fracture, side-to-side laxity, location of bone contusion, medial and lateral tibial/meniscal slope, and mechanical axis angle. Receiver operating characteristic curves and area under the curve were evaluated. A prediction model was developed by multivariable regression with generalized estimating equations. Results: Overall, 95 patients (34.5%) were confirmed as having a ramp lesion. The sensitivity of MRI for ramp lesions was 85.3%, and specificity was 78.3%. Significant risk factors for ramp lesion were as follows: posterior medial tibial plateau bone contusion on MRI (odds ratio [OR], 4.201; 95% CI, 2.081-8.482; P < .001), ≥3 months from injury (OR, 4.818; 95% CI, 2.158-10.757; P < .001), varus knee >3° (OR, 2.339; 95% CI, 1.048-5.217; P = .038), steeper medial tibial slope (OR, 1.289; 95% CI, 1.002-1.66; P = .049) and meniscal slope (OR, 1.464; 95% CI, 1.137-1.884; P = .003), and gradual lateral tibial slope (OR, 0.775; 95% CI, 0.657-0.914; P = .002). The area under the curve for the prediction model developed by logistic regression was 0.779 (sensitivity, 75.8%; specificity, 71.7%; P < .001) for ramp lesions. Conclusion: Care should be taken with patients who have significant risk factors for ramp lesions, including bone contusion at the posterior medial tibial plateau, chronic injury, steeper medial tibial and meniscal slope, gradual lateral tibial slope, and varus knee >3°.
Inflammatory Response of Articular Cartilage to Femoroacetabular Impingement in the Hip
Authors: Haneda Masahiko , Rai Muhammad Farooq , O’Keefe Regis J. , Brophy Robert H. , Clohisy John C. , Pascual-Garrido Cecilia 
Published: May 2020

Background: Femoroacetabular impingement (FAI) has been proposed as an etiologic factor in up to 50% of hips with osteoarthritis (OA). Inflammation is thought to be one of the main initiators of OA, yet little is known about the origin of intra-articular inflammation in FAI hips. Hypothesis: Articular cartilage from the impingement zone of patients with FAI has high levels of inflammation, reflecting initial inflammatory process in the hip. Study Design: Controlled laboratory study. Methods: Head-neck cartilage samples were obtained from patients with cam FAI (cam FAI, early FAI; n = 15), advanced OA secondary to cam FAI (FAI OA, late FAI; n = 15), and advanced OA secondary to developmental dysplasia of the hip (DDH OA, no impingement; n = 15). Cartilage procured from young adult donors (n = 7) served as control. Safranin O–stained sections were assessed for cartilage abnormality. Tissue viability was detected by TUNEL assay. Immunostaining of interleukin 1β (IL-1β), catabolic markers (matrix metalloproteinase 13 [MMP-13], a disintegrin and metalloproteinase with thrombospondin motif 4 [ADAMTS-4], aggrecan antibody to C-terminal neoepitope [NITEGE]), and an anabolic marker (type II collagen [COL2]) was performed to evaluate molecular inflammation and metabolic activity. The average percentage of immunopositive cells from the total cell count was calculated. Kruskal-Wallis test followed by Steel-Dwass post hoc test was used for multiple comparisons. Results: Microscopic osteoarthritic changes were more prevalent in cartilage of cam FAI and FAI OA groups compared with DDH OA and control groups. Cartilage in cam FAI and FAI OA groups, versus the DDH group, had higher expression of inflammatory molecules IL-1β (69.7% ± 18.1% and 72.5% ± 13.2% vs 32.7% ± 14.4%, respectively), MMP-13 (79.6% ± 12.6% and 71.4% ± 18.8% vs 38. 5% ± 13.3%), ADAMTS-4 (83.9% ± 12.2% and 82.6% ± 12.5% vs 45.7% ± 15.5%), and COL2 (93.6% ± 3.9% and 92.5% ± 5.8% vs 53.3% ± 21.0%) ( P < .001). Expression of NITEGE was similar among groups (cam FAI, 89.7% ± 7.7%; FAI OA, 95.7% ± 4.7%; DDH OA, 93.9% ± 5.2%; P = .0742). The control group had minimal expression of inflammatory markers. Inflammatory markers were expressed in all cartilage zones of early and late FAI but only in the superficial zone of the no impingement group. Conclusion: Cartilage from the impingement zone in FAI is associated with a high expression of inflammatory markers, extending throughout all cartilage zones. Clinical Relevance: Inflammation associated with FAI likely has a deleterious effect on joint homeostasis. Further clinical and translational studies are warranted to assess whether and how surgical treatment of FAI reduces molecular inflammation.
Indo-Nepal Trade and Investment: An Analysis
Authors: Taneja Nisha , Prakash Shravani , Bimal Samridhi , Garg Sakshi , Roy Riya 
Published: May 2020

India and Nepal have traditionally shared a unique relationship of friendship and economic cooperation. The relationship is characterised by an open and people-friendly border and is built on shared historical, cultural, linguistic and ethnic links between people residing in India and Nepal. With Nepal being a priority under India ‘Neighborhood First’ policy, strengthening the economic relationship holds immense significance and potential for both the countries. While the political relations between India and Nepal have been extensively studied, there is not much literature that explores the economic relationship between the two nations. This is an important issue to study, as India is Nepal’s largest export market, the biggest source of its imports, the top investor of foreign capital stock and among the largest donors of foreign aid. India also provides Nepal transit facility through its territory to access seaports for trading with the rest of the world. Given this, the main objective of this article is to suggest policy measures, which can increase bilateral trade and investment between India and Nepal. The article analyses the bilateral trade patterns and estimates the maximum additional trade potential. A wide range of issues of importance pertaining to bilateral trade, including tariffs, levy of an agricultural reform fee, under utilisation of the tariff rate quota, non-tariff measures, issues related to Rules of Origin (ROO) and physical barriers to cross-border movement of goods are discussed. The trends and changing sectoral composition of India’s investment in Nepal and barriers and opportunities for Indian investment in Nepal are also analysed. The article concludes by charting a way forward for bolstering economic cooperation between the two countries by listing down recommendations for enhancing trade, addressing non-tariff barriers, upgrading infrastructure to improve connectivity and enhancing Indian FDI in Nepal. JEL Classification: F10, F13, F15, F50, F53, P45
Bees Out of the Pandora’s Box: Economic Consequences of National Register in Assam
Authors: Sengupta Atanu , De Sanjoy 
Published: May 2020

In India, at present, there is a lot of hue and cry for and against the National Register of Citizens (NRC) in Assam. All the arguments are however based on false perception of migration and its ill or well effects on the economy. The latest 2011 Census does not provide the migration tables in detail. Hence, we had no other option but to use the Census 2001 data to understand the nature and trend of migration in Assam. Our analysis suggests that the recent uproar over illegal migrants from neighboring country in Assam is more of a myth than reality and does not hold much economic justification. Firstly, official data suggests that the flow of internal migration in various districts of Assam is miniscule. Moreover, it is showing a declining trend over the last few decades. The historical international migration that took place in Assam was due to mainly ‘push’ factor and no such ‘push’ factors have been in sight in the last few decades. Secondly and more importantly, migration of any form (though waning in Assam) adds to the prosperity and well-being of the state. JEL: J61, J6, Q56
Detection, localization, and characterization of vision-threatening features of microaneurysms using optical coherence tomography angiography in diabetic maculopathy
Authors: Khatri Anadi , Pradhan Eli , KC Bal Kumar , Kharel Muna , Rijal Roshija Khanal , Timalsena Satish , Gurung Jeena , Gautam Sudhir , KC Ashma 
Published: May 2020

Introduction Diabetic maculopathy is a leading retinal cause of blindness. This study was conducted using optical coherence tomography angiography and noninvasive imaging modalities. Microaneurysms were evaluated for location, flow, and adjacent retinal tissue changes to establish knowledge of possible vision-threatening features. Methodology: This is a hospital-based, cross-sectional observational study. Eighteen patients with diabetic maculopathy were included in the study. Fundus photo, red-free filter image, infrared images with shadowgrams, optical coherence tomography cross sections, and optical coherence tomography angiography were analyzed. Mean, standard deviation, odds ratio, and 95% confidence interval were used for statistical analysis, and p-value of <0.05 was considered statistically significant where applicable. Results A total of 64 microaneurysms were evaluated. Forty-six (71.8%) microaneurysms were identifiable in all imaging modalities. In total, 53 (82.8%) were high-flow microaneurysms and 11 (17.2%) were low-flow microaneurysms. Thirty-eight of the high-flow microaneurysms (71.6% of the high-flow microaneurysms) were found in the deep capillary plexus, while only 15 (28.4% of the high-flow microaneurysms) were found in the superficial capillary plexus. Twenty-seven (71%) of the high-flow microaneurysms in deep capillary plexus were present in the areas of retinal thickening (odds ratio: 4.5, 95% confidence interval: 1.26–16.0, p = 0.02). A total of 11 microaneurysms were classified as low-flow microaneurysms and identified using fundus photo, red-free filter image, infrared images with shadowgrams, and optical coherence tomography—cross sections. They had a tendency to be present in the areas of decreased capillary plexus density (odds ratio: 25.6, 95% confidence interval: 5.09–128.7, p = 0.001). Conclusion Noninvasive imaging modalities combined with optical coherence tomography angiography can provide valuable information regarding microaneurysms. Certain features such as location and flow may help in predicting impending macular edema or ischemia.
Risk Factors for Cardiovascular Events in Patients on Antidementia Medications
Authors: He Meiqi , Stevenson James M. , Zhang Yuting , Hernandez Inmaculada 
Published: May 2020

Objective: To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications. Methods: Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events. Results: Incidence rate of at least 1 cardiovascular event was 25.1%. Fifty-five factors were identified from the 10 381 candidate variables by the combined model with a c-statistic of 67% and an accuracy of 75%. Factors associated with increased risk of cardiovascular events include history of heart rhythm disorders, alteration of consciousness (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.14-1.36), and usage of β-blockers (OR: 1.19; 95% CI: 1.13-1.27). Conclusions: Clinicians should consider the increased risk of cardiovascular events in patients with AD with heart rhythm disorders and on β-blockers.
Valuing relationships: The impact of a sensory program on the interactions of adolescents with severe-to-profound intellectual disabilities
Authors: Yuile Lauren Emily , Smidt Andy , Quinlan Sinead 
Published: May 2020

Background: People with severe-to-profound intellectual disabilities often lack meaningful interactions with others. Communication partners need to be skilled in identifying and responding to often-subtle behaviours. One method of facilitating interaction is the use of sensory-based stimuli. Method: This study measured the impact of sensory-based stimuli paired with behaviour chain interruptions for three participants in an alternating treatment design using a novel intervention, SensEngage. Measurements included behaviours previously identified as indicating person engagement, self-engagement, happiness as well as participants’ use of potential communicative acts (PCAs). Results: The results showed increased person engagement and happiness in the SensEngage condition compared to the non-sensory condition for all three participants. An increased use of PCAs and decrease in self-engagement were observed for two participants. Conclusions: SensEngage appears to positively impact person engagement, happiness, PCAs and self-engagement for people with severe-to-profound intellectual disabilities.
Elbow flexion strength and contractile activity after partial ulnar nerve or intercostal nerve transfers for brachial plexus injuries
Authors: Chia Dawn Sinn Yii , Doi Kazuteru , Hattori Yasunori , Sakamoto Sotetsu 
Published: May 2020

We compared the outcomes of 23 partial ulnar nerve and 15 intercostal nerve transfers for elbow flexion reconstruction in patients with C56 or C567 brachial plexus injuries using manual muscle power, dynamometric measurements of elbow flexion strength and electromyography. The range of elbow flexion and muscle strength recovery to Grade 3 or 4 were comparable between the two groups. The patients with C567 injuries had significantly stronger eccentric contraction after the partial ulnar nerve transfer than after the intercostal nerve transfer ( p < 0.05). Electromyography of individual muscles demonstrated that the patients with partial ulnar nerve transfers were unable to voluntarily isolate biceps contraction and recruited forearm flexors and extensors. The patients after partial ulnar nerve transfer had significantly more activity of the forearm muscles during concentric elbow flexion than after intercostal nerve transfers ( p < 0.05). We conclude that partial ulnar nerve transfers were superior to intercostal nerve transfers when assessed quantitatively with the dynamometer to evaluate elbow flexion, although simultaneous recruitment of forearm muscles may have contributed to the increased elbow flexion strength in the patients with the partial ulnar nerve transfer. Level of evidence: III