bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA)
Authors: Brugnoli Federica , Grassilli Silvia , Cardinale Vincenzo , Carpino Guido , Gaudio Eugenio , Alvaro Domenico , Capitani Silvano , Bertagnolo Valeria 
Published: November 2020

AbstractAll-trans retinoic acid (ATRA) promotes the development and the function of insulin producing cells and induces partial differentiation of pancreatic tumor cells. A number of evidences clearly indicate that the ATRA mediated signaling may have a substantial role in therapeutic approaches based on restoration of functional β-cells. Among the proteins up-regulated by ATRA, Vav1 is involved in maturation and function of haematopoietic cells and is essential for retinoids induced differentiation of tumor promyelocytes. The presence of Vav1 in solid tissues, including pancreas, is considered ectopic and no role in the differentiation of human epithelial cells has so far been described. We demonstrated here that Vav1 sustains the maturation to β-cells of the normal precursors human Biliary Tree Stem/progenitor Cells (hBTSCs) induced by a differentiation medium containing ATRA and that, in the mature normal pancreas, insulin-producing cells express variable levels of Vav1. Using pancreatic ductal adenocarcinoma (PDAC)-derived cells, we also revealed that the ATRA induced up-modulation of Vav1 is essential for the retinoid-induced trans-differentiation of neoplastic cells into insulin producing cells. The results of this study identify Vav1 as crucial molecule in ATRA induced maturation of insulin producing cells and suggest this protein as a marker for new strategies ended to restore functional β-cells.
Effects of Different Extraction Solvents on Oil Extracted from Jatropha Seeds and the Potential of Seed Residues as a Heat Provider
Authors: Keneni Yadessa Gonfa , Bahiru Legesse Adane , Marchetti Jorge Mario 
Published: November 2020

AbstractThe present study focuses on the determination of oil contents of thirteen different jatropha seed collections from Ethiopia. The oil was extracted with a Soxhlet extractor using n-hexane which was selected out of four different solvents: diethyl ether, ethanol, n-heptane, and n-hexane. Cotton and thimble were used as filter for the extractions. Some properties of the oil of Chali seed collection and a sample of mixed oils (a mixture of equal volume of oils from thirteen different seed collections) were determined. The energy contents of selected de-oiled jatropha seed residues were also estimated. In the extraction with cotton and thimble, the largest percentage of oil yield was obtained from Dana seed (48.29%) and Chali seed (45.79) collections, respectively. The acid value (1.32 mg KOH/g) and percentage of free fatty acids (%FFA) (0.66%) of Chali seed oil were lower than the acid value (2.12 mg KOH/g) and %FFA (1.06%) of the mixed oil, and thus, the former oil is more suitable for alkaline-catalyzed biodiesel production. The iodine values of both Chali seed oil (116.02 g/100 g) and mixed oil (109.24 g/100 g) did not exceed the maximum standard for biodiesel according to the European EN 14214 specification, and the oils could be used for biodiesel production. The gross calorific values of de-oiled jatropha seed residues after oil extraction were found to range from 18.57 to 24.03 MJ/kg, and with the average value of 19.64 MJ/kg. Thus, the de-oiled seed residues can be used as the source of heat.
Sea, sickness and cautionary tales: a multi-isotope study from a post-mediaeval hospital at the city-port of Gibraltar (AD 1462–1704)
Authors: Lightfoot Emma , Pomeroy Emma , Grant Jennifer , O’Connell Tamsin C. , le Roux Petrus , Zakrzewski Sonia , Inskip Sarah , Benady Sam , Finlayson Clive , Finlayson Geraldine , Lane Kevin 
Published: November 2020

AbstractDuring the sixteenth to eighteenth centuries, Spanish ships sailed around the globe connecting Spain to its colonies. While documentary records offer rich details concerning life on board ship, archaeological information is essential to generating a full picture of the past. The cemetery at Old St Bernard’s Hospital, Gibraltar, provides an opportunity to study the skeletal remains of sailors. Following previous osteological research, carbon, nitrogen, oxygen and strontium isotope analyses were undertaken on thirty-three of these individuals. The results show that the, largely male, individuals had various different diets during life and came from several different places. Diets were largely based on C3food chains; some individuals consumed C3foods with low δ13C values; others consumed some marine foods, and a few individuals had a high trophic level diet, through the consumption of either freshwater resources or a high proportion of animal protein. The individuals spent their childhoods in several different places, although these homelands do not correlate simply with dietary variation. This variety in diets and homelands is consistent with our expectations for this hospital site given its location in a post-mediaeval entrepôt. The interpretation of these results are greatly helped by the available historical information and this has broader implications for the interpretation of isotope data elsewhere where the historical context of the site and the mobility patterns of the individuals are less well known.
Diversity in Shade and Light Leaf Morphology in Beech Populations of South Rodopi Mountains
Authors: Boutsios Stefanos , Vidalis Amaryllis , Adamidis George C. , Hatziskakis Seraphim , Varsamis Georgios , Tsiripidis Ioannis , Karanikola Paraskevi , Papageorgiou Aristotelis C. 
Published: November 2020

AbstractThe size and shape of tree leaves and their variation within the canopy are the result of both physiological plasticity and an overall adaptive strategy against unfavourable environmental conditions. In this study, diversity patterns at leaf morphological traits will be described within and among populations of trees with different phylogenetic background. Beech (Fagus sp.) is a widespread tree in Eurasia, represented by two species; F. sylvatica in Europe and F. orientalis in eastern Europe and Asia. Both species appear in the Rodopi mountains, in southeast Balkans. Five beech populations were sampled in the southern slopes of Rodopi along a west–east gradient representing an established transitional zone between the two beech species. The diversity of six leaf traits was examined in shade leaves and leaves exposed to direct irradiation. Significant differences appeared among populations and among the two shading classes. Western beech populations consisted of trees with smaller leaves and fewer veins and were morphologically closer to F. sylvatica, while eastern populations seemed to be closer to F. orientalis. Shade leaves were constantly larger and less round than light leaves, probably due to different light harvesting strategies. The differences between populations were larger for shade leaves than for light leaves and presented a clear east–west trend, consistent to the differentiation pattern provided by previous genetic studies in the same region. Our results indicate that shade leaves probably maintain their size and shape independent from light irradiation and therefore may better express genetic differences among populations.
Life above water: small-scale fisheries as a human experience
Authors: Jentoft Svein 
Published: November 2020

Abstract“Life under water” is UN Sustainable Development Goal No. 14, under which small-scale fisheries fall. Yet, most of what is happening in small-scale fisheries, and certainly those things that are interesting to social scientists, are taking place above water—on the water and by the water. Small-scale fishers make their living off the fish that swims in the ocean, but they do so with the lives they construct for themselves and with others on land. Therefore, small-scale fishers depend on their communities as much as they depend on the fish, their boats, and gear. It is as members of communities that fishers acquire the knowledge, energy, motivation, and meaning they need to carry out their work. For fisheries social scientists, the community is a unit of analysis. However, fisheries communities are not isolated from what is happening outside them. Consequently, social scientists focus on forces at higher scales. Still, I argue that it is important that they do not lose sight of local communities, because if they do they also lose the sight of small-scale fisheries.
Promoting austenite formation in laser welding of duplex stainless steel—impact of shielding gas and laser reheating
Authors: Baghdadchi Amir , Hosseini Vahid A. , Hurtig Kjell , Karlsson Leif 
Published: November 2020

AbstractAvoiding low austenite fractions and nitride formation are major challenges in laser welding of duplex stainless steels (DSS). The present research aims at investigating efficient means of promoting austenite formation during autogenous laser welding of DSS without sacrificing productivity. In this study, effects of shielding gas and laser reheating were investigated in welding of 1.5-mm-thick FDX 27 (UNS S82031) DSS. Four conditions were investigated: Ar-shielded welding, N2-shielded welding, Ar-shielded welding followed by Ar-shielded laser reheating, and N2-shielded welding followed by N2-shielded laser reheating. Optical microscopy, thermodynamic calculations, and Gleeble heat treatment were performed to study the evolution of microstructure and chemical composition. The austenite fraction was 22% for Ar-shielded and 39% for N2-shielded as-welded conditions. Interestingly, laser reheating did not significantly affect the austenite fraction for Ar shielding, while the austenite fraction increased to 57% for N2-shielding. The amount of nitrides was lower in N2-shielded samples compared to in Ar-shielded samples. The same trends were also observed in the heat-affected zone. The nitrogen content of weld metals, evaluated from calculated equilibrium phase diagrams and austenite fractions after Gleeble equilibrating heat treatments at 1100 °C, was 0.16% for N2-shielded and 0.11% for Ar-shielded welds, confirming the importance of nitrogen for promoting the austenite formation during welding and especially reheating. Finally, it is recommended that combining welding with pure nitrogen as shielding gas and a laser reheating pass can significantly improve austenite formation and reduce nitride formation in DSS laser welds.
Postheroische Perspektiven oder Die Signifikanz des Verkennens im Hildebrandslied
Authors: Petersen Christoph 
Published: November 2020

ZusammenfassungDer Beitrag stellt zum einen die These auf, dass das Hildebrandslied den erzählten Vater-Sohn-Kampf aus Hildebrands heroischer Exorbitanz ableitet, die im Figurendialog analytisch vorgeführt wird. Die darin zum Ausdruck kommende Reflexionsdistanz des Liedes zu seinem Gegenstand kann als postheroische Perspektive stricto sensu bezeichnet werden. Da diese Perspektive somit bereits in einem frühesten Zeugnis europäischer Heldenepik konstitutiv für die narrative Sinngebung ist, schlägt der Beitrag zum anderen vor, die postheroische Perspektive als ein heuristisches Instrument zu gebrauchen, mit dem nicht nur Erscheinungsweisen und Entwicklungen der europäischen Heldenepik neu beurteilt werden können, sondern auch das gesellschaftliche Relevanzpotenzial von ›Heldentum‹ bis heute im Rückbezug auf jene Heldenepik erklärt werden kann.
Should liberal government regulate male circumcision performed in the name of Jewish tradition?
Authors: Cohen-Almagor Raphael 
Published: November 2020

AbstractThe word "circumcision" comes from Latin circum (meaning "around") and cædere (meaning "to cut"). Cultural and religious justifications are employed to convince members of the community as well as outsiders that circumcision is reasonable and just. The purpose of the discussion is to suggest some cardinal changes to the practice of male circumcision in order to make it more humane and less painful to its subjects. Balancing between group rights and the rights of the child, it is essential to avoid unnecessary suffering. It is one of the liberal state’s obligations to protect the best interests of vulnerable third parties. The article opens with some preliminary data about male circumcision and then explains its importance in Judaism. It examines the medical reasons for male circumcision and the risks involved in the practice; subsequently, it discusses the critique of male circumcision. The article also highlights the points of agreement and disagreement between those supporting and opposing the ritual and insists that male circumcision should be performed by using anaesthesia. The final part of the article includes a proposal for humane male circumcision that considers religious sentiments and the rights of the child, aiming to strike a reasonable balance between competing interests. I hope the proposal will be debated in parliaments in the western world.
Suboptimal Outcome with Endovascular Thrombectomy: Will Acute Stroke Unit Help?
Authors: Trivedi Reva , Alcock Susan , Trivedi Anurag , Ghrooda Esseddeeg , McEachern James , Shankar Jai 
Published: November 2020

ABSTRACT:Endovascular thrombectomy (EVT) has revolutionized the care of patients with acute ischemic stroke. The efficacy of EVT is dependent on the optimal setup of a stroke system. Extrapolating the results of clinical trials to any individual stroke center should be done with caution. This is more important for centers with suboptimal stroke systems of care. The Canadian registry has helped highlight the suboptimal outcome post EVT in Manitoba. This could potentially be optimized with the addition of an acute stroke unit in the near future. Our study will serve as a baseline for future improvement in acute stroke care.
Post-nasal voicing in Japanese classifiers as exceptional triggering: implications for Indexed Constraint Theory
Authors: Burness Phillip , McMullin Kevin 
Published: November 2020

AbstractIndexed constraints are often used in constraint-based phonological frameworks to account for exceptions to generalizations. A point of contention in the literature on constraint indexation revolves around indexed markedness constraints. While some researchers argue that only faithfulness constraints should be indexed, others argue that markedness constraints should be eligible for indexation as well. This article presents data from Japanese for which a complete synchronic analysis requires indexed markedness constraints but argues that such constraints are only necessary in cases where a phonological repair applies across a morpheme boundary. We then demonstrate that algorithms for learning grammars with indexed constraints can be augmented with a bias towards faithfulness indexation and discuss the advantages of incorporating such a bias, as well as its implications for the debate over the permissibility of indexed markedness constraints.
Bounds for twisted symmetric square L-functions via half-integral weight periods
Authors: Nelson Paul D. 
Published: November 2020

Abstract
We establish the first moment bound

$$\begin{align*}\sum_{\varphi} L(\varphi \otimes \varphi \otimes \Psi, \tfrac{1}{2}) \ll_\varepsilon p^{5/4+\varepsilon} \end{align*}$$

for triple product L-functions, where

$\Psi $

is a fixed Hecke–Maass form on

$\operatorname {\mathrm {SL}}_2(\mathbb {Z})$

and

$\varphi $

runs over the Hecke–Maass newforms on

$\Gamma _0(p)$

of bounded eigenvalue. The proof is via the theta correspondence and analysis of periods of half-integral weight modular forms. This estimate is not expected to be optimal, but the exponent

$5/4$

is the strongest obtained to date for a moment problem of this shape. We show that the expected upper bound follows if one assumes the Ramanujan conjecture in both the integral and half-integral weight cases.

Under the triple product formula, our result may be understood as a strong level aspect form of quantum ergodicity: for a large prime p, all but very few Hecke–Maass newforms on

$\Gamma _0(p) \backslash \mathbb {H}$

of bounded eigenvalue have very uniformly distributed mass after pushforward to

$\operatorname {\mathrm {SL}}_2(\mathbb {Z}) \backslash \mathbb {H}$

.

Our main result turns out to be closely related to estimates such as

$$\begin{align*}\sum_{|n| < p} L(\Psi \otimes \chi_{n p},\tfrac{1}{2}) \ll p, \end{align*}$$

where the sum is over those n for which

$n p$

is a fundamental discriminant and

$\chi _{n p}$

denotes the corresponding quadratic character. Such estimates improve upon bounds of Duke–Iwaniec.
The construction problem for Hodge numbers modulo an integer in positive characteristic
Authors: van Dobben de Bruyn Remy , Paulsen Matthias 
Published: November 2020

AbstractLetkbe an algebraically closed field of positive characteristic. For any integer$m\ge 2$, we show that the Hodge numbers of a smooth projectivek-variety can take on any combination of values modulom, subject only to Serre duality. In particular, there are no non-trivial polynomial relations between the Hodge numbers.
Information and resources important to the quality of life of people living with multiple sclerosis
Authors: Bishop Malachy , Rumrill Stuart , McDaniels Bradley , Li Jian , Fraser Robert , Rumrill Phillip D. , Bhattarai Muna , Park Mirang 
Published: November 2020

AbstractMultiple sclerosis (MS) is a chronic, typically progressive immune-mediated disease characterized by inflammation and demyelination in the central nervous system (CNS), and is associated with a wide range of neurological, physical, and psychosocial effects. For people living with MS, access to relevant, timely, and accessible health information and resources may contribute to effective illness management, psychosocial health, and quality of life (QOL). In this study, we sought to increase understanding of the specific types of information most wanted by people with MS, as well as the sources and effects of this information. Specifically, we surveyed 748 adults with MS about (a) the sources from which they obtain information about MS, (b) the type of information that is most important in terms of improving their QOL, and (c) specific topics about which they would like to have more information, services, or resources. Content analysis of the qualitative results demonstrated the diversity of information sources accessed by people with MS and the importance of providing information through different formats and media. The participants prioritized information related to new MS medications and treatments, physical and mental health and wellness, and local opportunities for support. Implications for practicing rehabilitation counselors are discussed.
“Glass half full: cautious optimism and the future of Black women political elites in America”
Authors: Brown Nadia E. , Allen Gershon Sarah 
Published: November 2020

AbstractIn this essay, we place Black women's electoral challenges and opportunities in context. We situate this year of “Black Women Candidates” as an anomaly, but one that has been a long in the making. We also point to the appeal of Black women lawmakers among voters to mirror Alberder Gillespie's claims in this epigraph. We note that Black women have long been the backbone of the Democratic Party and are willing to use their clout for their own political means. Furthermore, given the unique ways that Black women represent their constituents, an influx of Black women into governing bodies may have a substantial, lasting impact on policy-making. We conclude with insights from our own research and that of other scholars on Black women to demonstrate future avenues of scholarly research.
Petri nets based on Lawvere theories
Authors: Master Jade 
Published: November 2020

AbstractWe give a definition of Q-net, a generalization of Petri nets based on a Lawvere theory Q, for which many existing variants of Petri nets are a special case. This definition is functorial with respect to change in Lawvere theory, and we exploit this to explore the relationships between different kinds of Q-nets. To justify our definition of Q-net, we construct a family of adjunctions for each Lawvere theory explicating the way in which Q-nets present free models of Q in Cat. This gives a functorial description of the operational semantics for an arbitrary category of Q-nets. We show how this can be used to construct the semantics for Petri nets, pre-nets, integer nets, and elementary net systems.
Diagnosing functional neurological disorder: seeing the whole picture
Authors: Lidstone Sarah C. , Nassif Walid , Juncos Jorge , Factor Stewart A. , Lang Anthony E. 
Published: November 2020

AbstractFunctional neurological disorder (FND) is a complex neuropsychiatric syndrome with many phenotypes that are commonly encountered in clinical practice. Despite the heterogeneity of FND, the rate of misidentification is consistently low. For the more common motor subtypes, there are clear positive clinical, electrophysiological, and rarely imaging criteria that can establish the diagnosis in the traditional sense. For nonmotor subtypes, the characterization may be less clear. Here, we argue that the current diagnostic criteria are not reflective of the current shared neuropsychiatric understanding of FND, and, as a result, provide an incomplete picture of the diagnosis. We propose a three-step diagnostic triad for FND, in which the traditional neurological diagnosis is only the first element. Other steps include psychiatric/psychological formulation, integration, and follow-up. We advocate that this diagnostic approach should be the shared responsibility of neurology and mental health professionals. Finally, a research agenda is proposed to address the missing factors in the field.
Development of a group-based diabetes education model for migrants with type 2 diabetes, living in Sweden
Authors: Hadziabdic Emina , Pettersson Sara , Marklund Helén , Hjelm Katarina 
Published: November 2020

Abstract

Aim:
To develop a diabetes education model based on individual beliefs, knowledge and risk awareness, aimed at migrants with type 2 diabetes, living in Sweden.

Background:
Type 2 diabetes is rapidly increasing globally, particularly affecting migrants living in developed countries. There is ongoing debate about what kind of teaching method gives the best result, but few studies have evaluated different methods for teaching migrants. Previous studies lack a theoretical base and do not proceed from the individuals’ own beliefs about health and illness, underpinned by their knowledge, guiding their health-related behaviour.

Methods:
A diabetes education model was developed to increase knowledge about diabetes and to influence self-care among migrants with type 2 diabetes. The model was based on literature review, on results from a previous study investigating knowledge about diabetes, on experience from studies of beliefs about health and illness, and on collaboration between researchers in diabetes care and migration and health and staff working in a multi-professional diabetes team.

Findings:
This is a culturally appropriate diabetes education model proceeding from individual beliefs about health and illness and knowledge, conducted in focus-group discussions in five sessions, led by a diabetes specialist nurse in collaboration with a multi-professional team, and completed within three months. The focus groups should include 4–5 persons and last for about 90 min, in the presence of an interpreter. A thematic interview guide should be used, with broad open-ended questions and descriptions of critical situations/health problems. Discussions of individual beliefs based on knowledge are encouraged. When needed, healthcare staff present at the session answer questions, add information and ensure that basic principles for diabetes care are covered. The diabetes education model is tailored to both individual and cultural aspects and can improve knowledge about type 2 diabetes, among migrants and thus increase self-care behaviour and improve health.