bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Fractional CO2 Laser for the Treatment of Genitourinary Syndrome of Menopause: A Prospective Multicenter Cohort Study
Authors: Li Jingran , Li Huan , Zhou Yanfei , Xie Meiqing , Miao Yali , Wang Luwen , Zhao Yan , Ying Ting , Hu Yan , Chen Yu , Chen Yaxiao , Sun Xiuli , Wang Jianliu 
Published: November 2020

Background and ObjectivesGenitourinary syndrome of menopause (GSM) is a common condition affecting of most postmenopausal women, which greatly impacks the quality of life,and need to treat. This prospective multicenter cohort study aimed to compare the efficacy and safety of the fractional carbon dioxide (CO2) laser with that of topical estrogen for vaginal treatment and relieving symptoms of genitourinary syndrome of menopause (GSM).Study Design/Materials and MethodsThis study included 162 postmenopausal patients who received vaginal laser or topical Estriol cream therapy between January 2017 and May 2019 at eight study centers in China. The degree of GSM‐related symptoms (vaginal burning, dryness, and dyspareunia) was evaluated using the Vaginal Health Index score (VHIS) and Visual Analog Scale (VAS) at baseline, 1, 3, 6, and 12 months posttreatment. The primary endpoint was the improvement in vaginal burning, dryness, and dyspareunia at 6 months after treatment. Multivariate logistic regression was used to compare the rate of improvement in the two groups.ResultsAt baseline, the laser and control groups showed no significant difference in the mean age, time after menopause, and the VHIS (all P > 0.05). In the laser group, compared with baseline, significant differences were seen in the VHIS after the first or second treatment session and at 1, 3, 6, and 12 months posttreatment (P < 0.01). In the control group, compared with baseline, the VHIS showed significant differences after 1, 3, and 6 months of treatment (P < 0.05). However, there was no significant difference after 3 and 6 months of follow‐up between the two groups (P > 0.05). The VHIS scores were significantly higher after 1 month (16.63 ± 2.79 vs. 15.57 ± 2.43) and 12 months (15.72 ± 2.59 vs. 12.12 ± 4.08) of treatment in both the groups (P < 0.05). At 6 months after treatment, both groups showed improvement in vaginal burning, vaginal dryness, and dyspareunia (P > 0.05). The VAS findings at 6 months posttreatment were significantly different when compared with the pretreatment findings (P < 0.001). There were no significant adverse effects in the two groups.ConclusionsFractional CO2 laser vaginal treatment could be a safe and effective option for treating symptoms of GSM, including vaginal burning, dryness, and dyspareunia. The improvement in symptoms was comparable with that seen with topical estrogen therapy and lasted for at least 6–12 months posttreatment. Lasers Surg. Med. © 2020 Wiley Periodicals LLC
Interfacial Fabrication of CNTs/PVDF Bilayer Actuator with Fast Responses to the Light and Organic Solvent Vapor Stimuli
Authors: Zhang Gui , Yan Luke , Ji Lingtong , Liu Chaohui , Zhang Lei , Zhang Wei , Nie Yujing , Xiao Peng , Chen Tao 
Published: November 2020

AbstractA multiple stimuli‐responsive actuator with an ability of rapid and sensitive responding is highly desirable for the development of biomimetic actuation applications. Herein, a bilayer actuator with fast and sensitive responses to acetone vapor and light stimuli is reported based on polyvinylidene fluoride (PVDF) membrane with a hierarchical porosity and macroscopic carbon nanotubes (CNTs) assembled film. The CNTs film with uniform and tunable thickness is prepared by a macroscopic interfacial assembly strategy and transferred integrally onto the PVDF membrane. Under the infrared light, this CNTs/PVDF bilayer actuator can bend rapidly within 1 s and generate large stress. Moreover, for the acetone vapor stimuli, the actuator bends within 0.19 s and also reverses in 1.24 s to the initial state, showing sensitive and fast responses to acetone stimuli, as well as outstanding stability and repeatability.
Gene expression responses to Zika virus infection in peripheral blood mononuclear cells from pregnant and non‐pregnant women
Authors: Lim Shen Jean , Seyfang Andreas , Dutra Samia , Kane Bradley , Groer Maureen 
Published: November 2020

AbstractCongenital Zika syndrome is caused by mother‐to‐fetus transmission of the Zika virus (ZIKV). Peripheral blood mononuclear cells (PBMCs) are permissive to ZIKV infection and may carry ZIKV to the placenta. To identify pregnancy‐related differences in PBMC responses against ZIKV infection, we compared gene expression profiles of ZIKV‐infected and non‐infected PBMCs cultured from pregnant and non‐pregnant women. ZIKV‐infected pregnant conditions generally overexpressed M1‐shifted pro‐inflammatory responses and underexpressed M2‐shifted anti‐inflammatory responses. Additionally, transcripts involved in osteoclast differentiation and cardiac myopathies were upregulated following ZIKV infection. Our results suggest potential roles of pregnancy‐induced immune dysregulation in shaping neonatal pathology associated with ZIKV infection.
Resting‐State Functional Connectivity Predicts STN DBS Clinical Response
Authors: Younce John R. , Campbell Meghan C. , Hershey Tamara , Tanenbaum Aaron B. , Milchenko Mikhail , Ushe Mwiza , Karimi Morvarid , Tabbal Samer D. , Kim Albert E. , Snyder Abraham Z. , Perlmutter Joel S. , Norris Scott A. 
Published: November 2020

ABSTRACTBackgroundDeep brain stimulation of the subthalamic nucleus is a widely used adjunctive therapy for motor symptoms of Parkinson's disease, but with variable motor response. Predicting motor response remains difficult, and novel approaches may improve surgical outcomes as well as the understanding of pathophysiological mechanisms. The objective of this study was to determine whether preoperative resting‐state functional connectivity MRI predicts motor response from deep brain stimulation of the subthalamic nucleus.MethodsWe collected preoperative resting‐state functional MRI from 70 participants undergoing subthalamic nucleus deep brain stimulation. For this cohort, we analyzed the strength of STN functional connectivity with seeds determined by stimulation‐induced (ON/OFF) 15O H2O PET regional cerebral blood flow differences in a partially overlapping group (n = 42). We correlated STN‐seed functional connectivity strength with postoperative motor outcomes and applied linear regression to predict motor outcomes.ResultsPreoperative functional connectivity between the left subthalamic nucleus and the ipsilateral internal globus pallidus correlated with postsurgical motor outcomes (r = −0.39, P = 0.0007), with stronger preoperative functional connectivity relating to greater improvement. Left pallidal‐subthalamic nucleus connectivity also predicted motor response to DBS after controlling for covariates.DiscussionPreoperative pallidal‐subthalamic nucleus resting‐state functional connectivity predicts motor benefit from deep brain stimulation, although this should be validated prospectively before clinical application. These observations suggest that integrity of pallidal‐subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation. © 2020 International Parkinson and Movement Disorder Society
An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease
Authors: Li Xiaolan , Zhang Zhi‐Hong , Zabed Hossain M. , Yun Junhua , Zhang Guoyan , Qi Xianghui 
Published: November 2020

AbstractInflammatory bowel disease (IBD) is complex, chronic, and relapsing gastrointestinal inflammatory disorders, which includes mainly two conditions, namely ulcerative colitis (UC) and Crohn's disease (CD). Development of IBD in any individual is closely related to his/her autoimmune regulation, gene‐microbiota interactions, and dietary factors. Dietary tryptophan (Trp) is an essential amino acid for intestinal mucosal cells, and it is associated with the intestinal inflammation, epithelial barrier, and energy homeostasis of the host. According to recent studies, Trp and its three major metabolic pathways, namely kynurenine (KYN) pathway, indole pathway, and 5‐hydroxytryptamine (5‐HT) pathway, have vital roles in the regulation of intestinal inflammation by acting directly or indirectly on the pro/anti‐inflammatory cytokines, functions of various immune cells, as well as the intestinal microbial composition and homeostasis. In this review, recent advances in Trp‐ and its metabolites‐associated intestinal inflammation are summarized. It further discusses the complex mechanisms and interrelationships of the three major metabolic pathways of Trp in regulating inflammation, which could elucidate the value of dietary Trp to be used as a nutrient for IBD patients.
Practical applications of brief screening questionnaires for autism spectrum disorder in a psychiatry outpatient setting
Authors: Kuru Yukiko , Nishiyama Takeshi , Sumi Satoshi , Suzuki Futoshi , Shiino Tomoko , Kimura Takuma , Hirai Kou , Kuroda Miho , Kamio Yoko , Kikuchi Shogo 
Published: November 2020

AbstractObjectivesThis study was designed to examine the diagnostic performance of the social and communication disorders checklist (SCDC) and strength and difficulties questionnaire (SDQ) to detect autism spectrum conditions (ASC), along with the social responsiveness scale‐second edition (SRS‐2) as reference, in a psychiatry outpatient setting.MethodsWe translated the SCDC into Japanese since its Japanese version was unavailable. We examined its test‐retest reliability as well as the internal consistency reliability and diagnostic performance of the three questionnaires among 41 Japanese psychiatric outpatients, using the best‐estimate diagnosis of ASC based on the diagnostic interview for social and communication disorders, as a gold standard.ResultsThe test‐retest reliability was high for the SCDC. Although the internal consistency reliability was high for the SCDC and SRS‐2, that was low for the prosocial and peer problem subscales of the SDQ. The performance of the SCDC, SDQ, and SRS‐2 to detect ASC was moderate: the area under the ROC curve of 0.78, 0.78, and 0.84, respectively.ConclusionsAlthough questionnaires to detect ASC, including the three examined, generally have only moderate performance in this setting, these can be successfully applied to high‐risk populations such as psychiatry outpatients, when multi‐level rather than dichotomous likelihood ratios are used.
Motion sensor‐acquired reachable workspace correlates with patient‐reported upper extremity activities of daily living (ADL) function in facioscapulohumeral dystrophy
Authors: Hatch Maya N. , Kurillo Gregorij , Chan Vicky , Han Jay J. 
Published: November 2020

AbstractBackgroundThis study examines the correlation, and clinical meaningfulness, between reachable workspace outcome and reported activities of daily living (ADL) function of individuals with facioscapulohumeral dystrophy (FSHD).MethodsTwenty‐one FSHD subjects with various disease severity (clinical severity scores 1‐4) underwent reachable workspace evaluation and completed the Quality of Life in Neurological Disorders (NeuroQoL) upper extremity questionnaire. Spearman and receiver operator curve analyses were performed.ResultsModerate correlation was found between NeuroQoL scores and total (ρ = 0.7609; P < .01), and upper‐quadrants relative surface areas (RSAs) (ρ = 0.6969; P < .01). Five specific items (ie, shirt on, shirt off, use spoon, pull on pants, pick‐up clothes) demonstrated even higher correlations with total (ρ = 0.8397; P < .01) and above shoulder (ρ = 0.8082; P < .01) RSAs. A total RSA cuffoff value of 0.70 would achieve 100% sensitivity and 94% specificity (area under the curve = 0.975).ConclusionsReachable workspace values identify when individuals have difficulties performing ADLs at home. This information improves patient monitoring, and clinical decision making by enabling more timely recommendations for medications, assistive devices, or considerations for clinical trial enrollments.
Distillation of the material point method cell crossing error leading to a novel quadrature‐based C0 remedy
Authors: Wilson Peter , Wüchner Roland , Fernando Dilum 
Published: November 2020

AbstractThe material point method (MPM) is a hybrid particle‐mesh scheme conceptually placed between mesh‐based and mesh‐free methods, combining aspects of both and well suited to solving large deformation engineering problems involving history‐dependent material models. A unique drawback of the MPM is the cell crossing error whereby material points crossing grid cells suddenly produce spurious stress oscillations leading to significant errors. After distilling the necessary conditions required for the cell crossing error, a novel quadrature‐based C0 enhancement scheme is proposed. The partitioned quadrature material point method (PQMPM) effectively mitigates the cell crossing error while retaining the linear Lagrangian basis and Dirac density function of the original MPM, rendering it easily integrable into existing MPM codebases. One and two‐dimensional examples illustrate the elimination of the cell crossing error, improvement of solution accuracy (particularly reliable stress prediction), local application of the scheme across dynamically varying arbitrary spatial and temporal regions and the reasonable additional computational costs against increased accuracy. Contrasting existing enhanced MPM schemes, the PQMPM only incurs additional computational cost exactly when and where cell crossing errors would otherwise occur and minimally diffuses local effects.
Data‐driven solvers for strongly nonlinear material response
Authors: Galetzka Armin , Loukrezis Dimitrios , De Gersem Herbert 
Published: November 2020

AbstractThis work presents a data‐driven magnetostatic finite‐element solver that is specifically well suited to cope with strongly nonlinear material responses. The data‐driven computing framework is essentially a multiobjective optimization procedure matching the material operation points as closely as possible to given material data while obeying Maxwell's equations. Here, the framework is extended with heterogeneous (local) weighting factors—one per finite element—equilibrating the goal function locally according to the material behavior. This modification allows the data‐driven solver to cope with unbalanced measurement data sets, that is, data sets suffering from unbalanced space filling. This occurs particularly in the case of strongly nonlinear materials, which constitute problematic cases that hinder the efficiency and accuracy of standard data‐driven solvers with a homogeneous (global) weighting factor. The local weighting factors are embedded in the distance‐minimizing data‐driven algorithm used for noiseless data, likewise for the maximum entropy data‐driven algorithm used for noisy data. Numerical experiments based on a quadrupole magnet model with a soft magnetic material show that the proposed modification results in major improvements in terms of solution accuracy and solver efficiency. For the case of noiseless data, local weighting factors improve the convergence of the data‐driven solver by orders of magnitude. When noisy data are considered, the convergence rate of the data‐driven solver is doubled.
Exploring educational engagement for parents with math anxiety
Authors: Kiss Allyson J. , Vukovic Rose 
Published: November 2020

AbstractLittle is known about how math anxiety in parents may relate to engagement in their children's education (i.e., parent involvement, parent educational expectations) or children's math outcomes (i.e., child math achievement and child math anxiety). The current exploratory study examined these relations between parents and their fifth grade children. The results indicate that parents with any reported math anxiety engaged in statistically less home–school conferencing, home‐based involvement, and held lower educational expectations. Parent educational expectations mediated the relation between parent math anxiety and both child math anxiety and child achievement. These results suggest that parent math anxiety can unintentionally influence how parents engage in behaviors that matter to schools. Furthermore, educational expectations may be a more important intervention target than parent math anxiety to support parents in their educational engagement. Our findings have implications for researchers and school‐based practitioners interested in better understanding how to support all parents with math anxiety.
Spectroscopic characterization for new model from Schiff base and its complexes
Authors: Jirjees Vian Yamin , Al‐Hamdani Abbas Ali Salih , Wannas Noor Mohamed , A. R Farqad , Dib Adnan , Al Zoubi Wail 
Published: November 2020

AbstractNew complexes have been prepared from the new ligand [2,2′‐(5,5‐dimethylcyclohexane‐1,3‐diylidene)bis(azan‐1‐yl‐1‐ylidene)dibenzoic acid] derived from 5,5‐dimethylcyclohexane‐1,3‐dione and 2‐aminobenzoic acid. Accordingly, its mono and binuclear Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) complexes were prepared. The prepared components have been characterized by various spectroscopic techniques and elemental analysis. The thermal stability of the ligand and its complexes were performed by TGA. It was found that all the complexes have excellent thermal stability and do not contain water molecules within their structure, but the ligand has little stability. Additionally, theoretical chemical calculation was performed of both electronic structure and spectroscopic properties of prepared Schiff base and its complexes. Moreover, the consequences predicted that the structure will be played a critical role in biological, liquid–liquid extraction, active transport applications.
Recent Advances in Renal Clearable Inorganic Nanoparticles for Cancer Diagnosis
Authors: Yin Ruiqi , Zhang Xiaochen , Ge Jianxian , Wen Ling , Chen Lei , Zeng Jianfeng , Li Zhen , Gao Mingyuan 
Published: November 2020

AbstractThe rapid growth of inorganic nanoparticles provides numerous opportunities for cancer diagnosis. Due to their adjustable and diverse characteristics that are strongly dependent on the size, morphology, charge, and the nature of surface coatings, they are widely used in the field of oncology. However, inorganic nanomaterials are usually difficult to degrade and excrete within a short time, resulting in long‐term in vivo retention and potential toxicity, which significantly hinders their translation into clinical practice. Therefore, the development of renal clearable inorganic nanomaterials that can excrete out of body within desired timeframe is of great significance to promote their clinical bioapplications. Herein, the recent advances in renal clearable inorganic nanoparticles for tumor diagnosis are focused on, and the factors affecting the renal clearance efficiency, with a view to understand the underlying metabolism mechanism and the relevant bioapplications, are discussed.
Self‐Assembly of Soft Cellulose Nanospheres into Colloidal Gel Layers with Enhanced Protein Adsorption Capability for Next‐Generation Immunoassays
Authors: Solin Katariina , Beaumont Marco , Rosenfeldt Sabine , Orelma Hannes , Borghei Maryam , Bacher Markus , Opietnik Martina , Rojas Orlando J. 
Published: November 2020

AbstractSoft cationic core/shell cellulose nanospheres can deform and interpenetrate allowing their self‐assembly into densely packed colloidal nanogel layers. Taking advantage of their water‐swelling capacity and molecular accessibility, the nanogels are proposed as a new and promising type of coating material to immobilize bioactive molecules on thin films and paper. The specific and nonspecific interactions between the cellulosic nanogel and human immunoglobulin G as well as bovine serum albumin (BSA) are investigated. Confocal microscopy, electroacoustic microgravimetry, and surface plasmon resonance are used to access information about the adsorption behavior and viscoelastic properties of self‐assembled nanogels. A significant BSA adsorption capacity on nanogel layers (17 mg m−2) is measured, 300% higher compared to typical polymer coatings. This high protein affinity further confirms the promise of the introduced colloidal gel layer, in increasing sensitivity and advancing a new generation of substrates for a variety of applications, including immunoassays, as demonstrated in this work.
Analysis of underivatized alditols in traditional Chinese medicines by liquid chromatography–tandem mass spectrometry based on ligand exchange chromatography
Authors: Wong Yiu‐Tung , Or Mei‐Sze , Lau Hoi‐Ho , Wong Sau‐Chun , Fung Wai‐Hong 
Published: November 2020

AbstractAlditols are potential chemical markers in traditional Chinese medicine for quality control purpose. For example, mannitol is one of the major compounds in Cordyceps sinensis. Galactitol is the proposed marker compound of formulated oral traditional Chinese medicine liquid “Fufangfufangteng Heji.” Development of a highly selective analytical method for unambiguous identification of selected alditols is of prime importance to assure the quality of these valued and precious traditional Chinese medicines. In this study, a liquid chromatography–tandem mass spectrometry method based on ligand exchange chromatography was developed to analyze and identify underivatized alditols such as galactitol, mannitol and sorbitol in different traditional Chinese medicines. The limits of detection of these alditols ranged from 0.7 to 1.4 mg/kg. The limits of quantification of these alditols ranged from 2.3 to 4.6 mg/kg. The method has been applied in the detection of alditols in various samples such as Cordyceps sinensis, Cordyceps militaris, and concentrated granule of Radix Celastrus orbiculatus. The results indicated that several underivatized alditols could be identified rapidly and unambiguously by liquid chromatography–tandem mass spectrometry on ligand exchange chromatography column.
Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially Pregelatinized Starches
Authors: Svačinová Petra , Mužíková Jitka , Ondrejček Pavel 
Published: November 2020

AbstractModified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study aims to evaluate and compare two partially pregelatinized starches, namely, Starch 1500 and Lycatab C, from the perspectives of compressibility, compactability, and lubricant sensitivity. Compressibility is evaluated by means of the compression energy profile and a stress relaxation test. Compactability is evaluated by means of the tablets tensile strength, and lubricant sensitivity is characterized by the lubricant sensitivity ratio (LSR) values. The lubricants employed are magnesium stearate and sodium stearyl fumarate at concentrations of 0.5% and 1%, respectively. In the case of the mixtures with 1% magnesium stearate, the influence of the mixing time is also evaluated. Starch 1500 shows better compressibility than Lycatab C due to its lower precompression and total energy values. On the opposite, the plasticity is higher for Lycatab C. This material has also better compactability, yields stronger tablets, but has higher lubricant sensitivity than Starch 1500. Different compressibility and compactability are found for Lycatab C and Starch 1500 and therefore, they cannot be easily interchanged in tablet manufacture.