bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights into the pathogenesis of Peyronie's disease: A narrative review
Authors: Krakhotkin Denis V. , Chernylovskyi Volodymyr A. , Mottrie Alexandre , Greco Francesco , Bugaev Ruslan A. 
Published: July 2020

AbstractPeyronie’s disease (PD) is a benign, progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea (TA) of the penis. This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathways, biochemical mechanisms, genetic factors responsible for fibrogenesis. A growing body of literature has shown that PD is a chronically impaired, localized, wound healing process within the TA and the Smith space. It is caused by the influence of different pathological stimuli, most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features, imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP), and suppressed antioxidant systems during chronic inflammation. Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor‐β1 signaling. The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators.
Supporting multi-point fan design with dimension reduction
Authors: Seshadri P. , Yuchi S. , Parks G.T. , Shahpar S. 
Published: July 2020

AbstractMotivated by the idea of turbomachinery active subspace performance maps, this paper studies dimension reduction in turbomachinery 3D CFD simulations. First, we show that these subspaces exist across different blades—under the same parametrisation—largely independent of their Mach number or Reynolds number. This is demonstrated via a numerical study on three different blades. Then, in an attempt to reduce the computational cost of identifying a suitable dimension reducing subspace, we examine statistical sufficient dimension reduction methods, including sliced inverse regression, sliced average variance estimation, principal Hessian directions and contour regression. Unsatisfied by these results, we evaluate a new idea based on polynomial variable projection—a non-linear least-squares problem. Our results using polynomial variable projection clearly demonstrate that one can accurately identify dimension reducing subspaces for turbomachinery functionals at a fraction of the cost associated with prior methods. We apply these subspaces to the problem of comparing design configurations across different flight points on a working line of a fan blade. We demonstrate how designs that offer a healthy compromise between performance at cruise and sea-level conditions can be easily found by visually inspecting their subspaces.
Material Suitability Testing for Nonmedical Grade Community Face Masks to Decrease Viral Transmission During a Pandemic
Authors: Varallyay Csanad , Li Ningcheng (Peter) , Case Brendan , Wolf Bryan 
Published: July 2020

AbstractObjectives:Cloth face covering has been recommended by the Centers for Disease Control and Prevention to decrease community viral transmission. This study aims to determine the filtration efficiency and airflow resistance of common household materials available for homemade mask production by comparing numbers of fabrics, various layers, and manipulation.Methods:Common household woven, knitted, and nonwoven fabrics were tested for filtration efficiency using a fit testing setup and airflow resistance with pressure gauge setup. Three different levels of layering (1, 2, and 4) were tested. Some fabric material was further tested after washing and drying. Filtration performance, the area under the fitted curve comparing airflow resistance and filtration efficiency, was calculated for each fabric material and compared.Results:Layering increased filtration efficiency and airflow resistance (P < 0.0001 and P < 0.01, respectively). Polyester felt demonstrated the highest filtration performance index (P < 0.0001), higher than all tested 100% cotton materials (all P < 0.05) as well as surgical masks (P < 0.05). Washing plus drying did not alter filtration performance significantly (P > 0.05).Conclusions:A filtration performance of common household fabrics were compared. Homemade mask designers and producers will have improved data to better balance effectiveness, availability, and comfort with the goal of decreasing community viral transmission.
Prone Positioning in Non-Intubated Patients With COVID-19 Outside of the Intensive Care Unit: More Evidence Needed
Authors: Ripoll-Gallardo Alba , Grillenzoni Luca , Bollon Jordy , della Corte Francesco , Barone-Adesi Francesco 
Published: July 2020

ABSTRACTThe coronavirus disease (COVID-19) pandemic has brought the Italian National Health System to its knees. The abnormally high influx of patients, together with the limited resources available, has forced clinicians to make unprecedented decisions and provide compassionate treatments for which little or no evidence is yet available. This is the case for the use of noninvasive positive pressure ventilation and continuous airway pressure ventilation, combined with prone position in patients with COVID-19 and acute respiratory distress syndrome treated outside of intensive care units. In our article, we comment on the evidence available, so far, and provide a brief summary of data collected at our health institution in Piedmont, Italy.
The Muddle of the ‘Westminster Model’: A Concept Stretched Beyond Repair
Authors: Russell Meg , Serban Ruxandra 
Published: July 2020

AbstractThe term ‘Westminster model’, widely used in both the academic and practitioner literatures, is a familiar one. But detailed examination finds significant confusion about its meaning. This article follows Giovanni Sartori's advice for ‘reconstructing’ a social science term whose meaning may be unclear through review of its use in the recent literature. It finds that many authors in comparative politics use the term ‘Westminster model’ without definition, while those providing definitions associate it with a large (and sometimes conflicting) set of attributes, and a set of countries often not demonstrating those attributes. Some have sought to respect this diversity by proposing variants like ‘Washminster’ or ‘Eastminster’, while others suggest that the term should be seen as a loose ‘family resemblance’ concept. But on examination it no longer meets even the – relatively weak – requirements for family resemblance. To end the muddle, and the risk of flawed inferences and false generalization, comparative scholars should drop this term, and select cases based on more precise attributes instead.
ABSOLUTE CHRONOLOGY OF GOSAN-RI-TYPE POTTERY, THE OLDEST MANUFACTURED POTTERY IN KOREA
Authors: Kim Myung-Jin , Go Jae-Won , Bang Mun-Bae , Hong Wan , Lee Gi-Kil 
Published: July 2020

ABSTRACTGosan-ri-type pottery (GTP) is a unique plant-fiber-tempered pottery from Korea and has only been found in Early Neolithic sites on Jeju Island. In this study, we conducted radiocarbon (14C) dating for one GTP sample and 10 charcoal samples collected from archaeological structures in which GTP was found in 2012. The measurement conditions, the internal quality assurance test, and the reliability test indicate that each 14C date is very reliable. However, the 14C dates of the charcoal samples were more accurate than that of the GTP sample due to contamination from younger humic acids. From the summary of all 14C dates of charcoal samples using the KDE model, we finally conclude that GTP was manufactured and utilized throughout the period 9610–9490 cal BP (7670–7550 BC) with 95.4% confidence level. This age corroborates the inference that GTP is the oldest known Korean Neolithic pottery.
A RADIOCARBON DATING APPROACH TO THE DEPOSITION AND REMOVAL OF HUMAN BONE REMAINS IN MEGALITHIC MONUMENTS
Authors: Aranda Jiménez Gonzalo , Díaz-Zorita Bonilla Marta , Hamilton Derek , Milesi Lara , Sánchez Romero Margarita 
Published: July 2020

ABSTRACTThe formation of commingled human bone assemblages is a key aspect for better understanding funerary rituals. The megalithic cemetery of Panoría (Spain) provides an excellent opportunity to explore bone assemblage formation thanks to the recent excavation of an undisturbed burial. For this purpose, we have approached the differential skeletal representation found between bone and teeth at the site through radiocarbon (14C) dating and Bayesian modeling. The comparison between the series of 14C dates on bone (n=12) and teeth (n=14) stress three main aspects: (1) the dates of teeth show a long period of funerary use before the deposition of the human bone remains; (2) both kinds of samples appear to be chronologically sequenced; the end of the teeth 14C series matches with the beginning of human bone deposition; and (3) bone remains span a short period, not more than a few decades, which probably represents the last episode of intense mortuary activity. These differences suggest that teeth could be the evidence of skeletal depositions subsequently removed from the tomb. The deposition and removal of bone remains emerge as key aspects in the formation of the bone assemblage.
Association between unhealthy plant-based diets and the metabolic syndrome in adult men and women: a population-based study in South Korea
Authors: Kim Hyunju , Lee Kyueun , Rebholz Casey M. , Kim Jihye 
Published: July 2020

AbstractNo studies have investigated the associations between established plant-based diet indices and the metabolic syndrome (MetS). We evaluated the associations between an overall plant-based diet index (PDI), healthy PDI (hPDI), unhealthy PDI (uPDI) and the MetS in a nationally representative sample using data from 14 450 Korean adults (≥19 years) in the Korea National Health and Nutrition Examination Survey 2012–2016. Dietary intakes were assessed by a semi-quantitative FFQ. In the PDI, all plant foods received positive scores. In the hPDI, only healthy plant foods received positive scores. In the uPDI, only unhealthy plant foods received positive scores. All indices reverse scored animal food intake. Multivariable logistic regression models were used to examine the associations between three PDI and the MetS by sex, adjusting for potential risk factors. A total of 23·3 % of Korean adults had the MetS. In the overall study population, individuals in the highest quintile of uPDI had greater odds (OR 1·54, 95 % CI 1·28, 1·86, Ptrend < 0·001) of the MetS than those in the lowest quintile. Higher uPDI score was associated with higher odds of hypertriacylglycerolaemia in men and abdominal obesity, high fasting glucose and hypertriacylglycerolaemia in women. No significant associations were observed between PDI, hPDI and the MetS. Greater adherence to unhealthy plant-based diets was associated with greater odds of the MetS and its components suggesting the importance of the quality of plant-based diet in South Korean adults. Sex differences may be considered when recommending plant-based diets for the prevention and management of metabolic diseases.
Nocturnal whey protein ingestion impairs post-prandial glucose tolerance at breakfast
Authors: Smith Eleanor S. , Adama Emmanuel , Clayton Keeley , Holbrey James , Palubiski Gabriel , Smith Harry A. , Gonzalez Javier T. , Betts James A. 
Published: July 2020

AbstractPoor post-prandial glucose control is a risk factor for multiple health conditions. The second-meal effect refers to the progressively improved glycaemic control with repeated feedings, an effect which is achievable with protein ingestion at the initial eating occasion. The most pronounced glycaemic response each day therefore typically occurs following breakfast, so the present study investigated whether ingesting protein during the night could improve glucose control at the first meal of the day. In a randomised crossover design, fifteen adults (seven males, eight females; age, 22 (sd3) years; BMI, 24·0 (sd2·8) kg/m2; fasting blood glucose, 4·9 (sd0·5) mmol/l) woke at 04.00 (sd1) hours to ingest 300 ml water with or without 63 g whey protein. Participants then completed a mixed-macronutrient meal tolerance test (1 g carbohydrate/kg body mass, 2356 (sd435) kJ), 5 h 39 min following the nocturnal feeding. Nocturnal protein ingestion increased the glycaemic response (incremental AUC) to breakfast by 43·5 (sd55·5) mmol × 120 min/l (P= 0·009,d= 0·94). Consistent with this effect, individual peak blood glucose concentrations were 0·6 (sd1·0) mmol/l higher following breakfast when protein had been ingested (P= 0·049,d= 0·50). Immediately prior to breakfast, rates of lipid oxidation were 0·02 (sd0·03) g/min higher (P= 0·045) in the protein condition, followed by an elevated post-prandial energy expenditure (0·38 (sd0·50) kJ/min,P= 0·018). Post-prandial appetite and energy intake were similar between conditions. The present study reveals a paradoxical second-meal phenomenon whereby nocturnal whey protein feeding impaired subsequent glucose tolerance, whilst increasing post-prandial energy expenditure.
A Distinctive Culture? The Sources of Public Support for Immigration in Canada, 1980–2019
Authors: Banting Keith , Soroka Stuart 
Published: July 2020

AbstractCanada has often been seen as immune from the powerful backlash against globalization and immigration that has driven political shifts elsewhere. This article challenges this belief, at least in part, by tracing the evolution of public attitudes toward immigration and analyzing the factors that have shaped the trajectory for over three decades. Drawing on nearly forty years of Environics Focus Canada surveys, combined with annual data on macro-economics and immigration flows, findings here suggest that Canadians’ tolerance toward immigration responds to immigration flows and is heavily influenced by macro-economic conditions.
Pharmacotherapy failure and progression to botulinum toxin injection in vestibular migraine
Authors: Liu Y F , Macias D , Donaldson L , Dornhoffer J R , Rizk H G 
Published: July 2020

AbstractObjectiveGiven the lack of evidence on patients with medically refractory vestibular migraine, this study aimed to identify factors associated with pharmacotherapy failure and progression to botulinum toxin injection in vestibular migraine.MethodsA retrospective cohort study was conducted on definite vestibular migraine patients from September 2015 to July 2019 who completed the Dizziness Handicap Inventory at least six weeks apart..ResultsThe study comprised 47 patients (mean age = 50.2 ± 15.8 years), with a mean follow-up time of 6.0 ± 6.0 months. The mean pre-treatment Dizziness Handicap Inventory score was 57.5 ± 23.5, with a mean reduction of 17.3 ± 25.2 (p < 0.001) at last follow up. Oscillopsia (r = 0.458, p = 0.007), failure of first medication (r = 0.518, p = 0.001) and pre-treatment Dizziness Handicap Inventory question 15 (an emotional domain question) score (r = 0.364, p = 0.019) were the only variables significantly correlated with progression to botulinum toxin injection.ConclusionMotion hypersensitivity, failure of first medication, and fear of social stigmatisation suggest a decreased treatment response. These symptoms may require more aggressive treatment at an earlier stage.
Targeting binge eating in bulimia nervosa and binge eating disorder using inhibitory control training and implementation intentions: a feasibility trial
Authors: Chami Rayane , Cardi Valentina , Lawrence Natalia , MacDonald Pamela , Rowlands Katie , Hodsoll John , Treasure Janet 
Published: July 2020

AbstractBackgroundThis trial examined the feasibility, acceptability, and effect sizes of clinical outcomes of an intervention that combines inhibitory control training (ICT) and implementation intentions (if-then planning) to target binge eating and eating disorder psychopathology.MethodsSeventy-eight adult participants with bulimia nervosa or binge eating disorder were randomly allocated to receive food-specific, or general, ICT and if-then planning for 4 weeks.ResultsRecruitment and retention rates at 4 weeks (97.5% and 79.5%, respectively) met the pre-set cut-offs. The pre-set adherence to the intervention was met for the ICT sessions (84.6%), but not for if-then planning (53.4%). Binge eating frequency and eating disorder psychopathology decreased in both intervention groups at post-intervention (4 weeks) and follow-up (8 weeks), with moderate to large effect sizes. There was a tendency for greater reductions in binge eating frequency and eating disorders psychopathology (i.e. larger effect sizes) in the food-specific intervention group. Across both groups, ICT and if-then planning were associated with small-to-moderate reductions in high energy-dense food valuation (post-intervention), food approach (post-intervention and follow-up), anxiety (follow-up), and depression (follow-up). Participants indicated that both interventions were acceptable.ConclusionsThe study findings reveal that combined ICT and if-then planning is associated with reductions in binge eating frequency and eating disorder psychopathology and that the feasibility of ICT is promising, while improvements to if-then planning condition may be needed.
Borderline personality disorder: stress reactivity or stress generation? A prospective dimensional study
Authors: Allen Timothy A. , Dombrovski Alexandre Y. , Soloff Paul H. , Hallquist Michael N. 
Published: July 2020

AbstractBackgroundIndividuals diagnosed with borderline personality disorder (BPD) often describe their lives as stressful and unpredictable. However, it is unclear whether the adversity faced by those with BPD is a product of stress reactivity or stress generation. Here, we examined the dynamic, prospective associations between BPD and stressful life events over 3 years. Given the heterogeneity present in BPD, we sought to understand which empirically derived dimensions of this heterogeneous disorder explain stress reactivity v. stress generation.MethodsParticipants included 355 individuals diagnosed with BPD and followed longitudinally at three annual assessments. Auto-regressive cross-lagged panel models were used to examine prospective associations between stressful life events and three latent dimensions implicated in BPD: negative affect, disinhibition, and antagonism.ResultsAntagonism and disinhibition, but not negative affect, prospectively predicted dependent stressful life events (events the individual may have some role in). Evidence for decompensation under stress was more tenuous, with independent stressful life events (those presumably outside the individual's control) predicting increases in negative affect.ConclusionsOur longitudinal study of a well-characterized clinical sample found more evidence for stress generation than for stress-induced decompensation in BPD. Stress generation in BPD is driven by externalizing dimensions: antagonism and disinhibition. These results highlight the utility of empirically derived dimensions for parsing heterogeneity present in BPD, leading to improvements in diagnostic evaluation, clinical prediction, and individualized approaches to treatment planning.
Exploring the identification, validation, and categorization of the cost and benefits of criminal justice in mental health: the PECUNIA project
Authors: Janssen Luca M. M. , Pokhilenko Irina , Evers Silvia M. A. A. , Paulus Aggie T. G. , Simon Judit , König Hans-Helmut , Brodszky Valentin , Salvador-Carulla Luis , Park A-La , Hollingworth W. , Drost Ruben M. W. A. ,   on behalf of the PECUNIA group
Published: July 2020

BackgroundMental health disorders and their treatments produce significant costs and benefits in both healthcare and non-healthcare sectors. The latter are often referred to as intersectoral costs and benefits (ICBs). Little is known about healthcare-related ICBs in the criminal justice sector and how to include these in health economics research.ObjectivesThe triple aim of this study is (i) to identify healthcare-related ICBs in the criminal justice sector, (ii) to validate the list of healthcare-related ICBs in the criminal justice sector on a European level by sector-specific experts, and (iii) to classify the identified ICBs.MethodsA scientific literature search in PubMed and an additional grey literature search, carried out in six European countries, were used to retrieve ICBs. In order to validate the international applicability of the ICBs, a survey was conducted with an international group of experts from the criminal justice sector. The list of criminal justice ICBs was categorized according to the PECUNIA conceptual framework.ResultsThe full-text analysis of forty-five peer-reviewed journal articles and eleven grey literature sources resulted in a draft list of items. Input from the expert survey resulted in a final list of fourteen unique criminal justice ICBs, categorized according to the care atom.ConclusionThis study laid further foundations for the inclusion of important societal costs of mental health-related interventions within the criminal justice sector. More research is needed to facilitate the further and increased inclusion of ICBs in health economics research.
How permanent were farms in the manorial system? Changes of farm occupancy in the nineteenth-century Russian Baltic Provinces of Estland and Livland
Authors: Lust Kersti 
Published: July 2020

AbstractThis article addresses how long tenant farmers in the Russian Baltic Provinces of Estland and Livland managed to occupy the farms and whether they transferred them within the family in the early phase of agricultural transformation (1841–1889). It contributes to the long-standing debate over the relative power of manorial lords and tenants in the (East Elbian) manorial system. Looking at individual-level data on the changes in tenantship on more than 1,000 farmsteads across 5 parishes, the article demonstrates the relative instability of tenant holdings and lack of independence in land transfers on noble manors.
Reversible privatisation. Conflict, bricolage, and the sale of common lands in the Spanish province of Navarre, 1808–1860
Authors: Lana-Berasain José-Miguel 
Published: July 2020

AbstractThe privatisation of communal assets tends to be presented as an irreversible linear movement that was driven from above. Based on a case study (Navarre, nineteenth century), this article seeks to give greater prominence to local players and their response to changing circumstances. The process thus appears less linear and compact by revealing certain anomalies, such as the reversibility of certain sales or the alienation of partial ownership rights that were compatible with the preservation of rights of use in favour of local councils and households, as an example of institutional bricolage. Against a backdrop of war and municipal bankruptcy, the privatisation of collective lands between 1808 and 1860 followed various paths, each one benefitting different social classes. Borrowers, outside investors and wealthy individuals accumulated large estates, but there was also a chance for peasants and local people to become property owners. The recovery of part of these lands on the back of social conflicts from 1884 onwards confirms that privatisation was not a fait accompli.