bluuebunny/crossref_metadata_2025_split huggingface dataset:
The brittle-to-ductile transition in cold-rolled tungsten sheets: the rate-limiting mechanism of plasticity controlling the BDT in ultrafine-grained tungsten
Authors: Bonnekoh Carsten , Reiser Jens , Hartmaier Alexander , Bonk Simon , Hoffmann Andreas , Rieth Michael 
Published: May 2020

AbstractConventionally produced tungsten (W) sheets are brittle at room temperature. In contrast to that, severe deformation by cold rolling transforms W into a material exhibiting room-temperature ductility with a brittle-to-ductile transition (BDT) temperature far below room temperature. For such ultrafine-grained (UFG) and dislocation-rich materials, the mechanism controlling the BDT is still the subject of ongoing debates. In order to identify the mechanism controlling the BDT in room-temperature ductile W sheets with UFG microstructure, we conducted campaigns of fracture toughness tests accompanied by a thermodynamic analysis deducing Arrhenius BDT activation energies. Here, we show that plastic deformation induced by rolling reduces the BDT temperature and also the BDT activation energy. A comparison of BDT activation energies with the trend of Gibbs energy of kink-pair formation revealed a strong correlation between both quantities. This demonstrates that out of the three basic processes, nucleation, glide, and annihilation, crack tip plasticity in UFG W is still controlled by the glide of dislocations. The glide is dictated by the mobility of the screw segments and therefore by the underlying process of kink-pair formation. Reflecting this result, a change of the rate-limiting mechanism for plasticity of UFG W seems unlikely, even at deformation temperatures well below room temperature. As a result, kink-pair formation controls the BDT in W over a wide range of microstructural length scales, from single crystals and coarse-grained specimens down to UFG microstructures.
Genome-wide identification of the ARF (auxin response factor) gene family in peach and their expression analysis
Authors: Diao Donghui , Hu Xiao , Guan Dan , Wang Wei , Yang Haiqing , Liu Yueping 
Published: May 2020

AbstractAuxin response factors (ARFs) are important transcription factors to relay auxin signaling. From the Genome Database for Rosaceae (GDR), we identified 17 peach ARF genes (PpARFs) encoding the proteins with three conserved domains. Their gene structure and functional domains were analyzed. Their transcriptional response to exogenous auxin treatment was tested and confirmed. We also expressed PpARF-GFP fusion reporters in tobacco leaves and observed their nuclear localization by fluorescence microscopy. It has been known that ARFs are widely involved in fruit development. We compared the expression pattern of all PpARFs in different tissues including the fruits at different developmental stages of two peach cultivars, “melting” and “stony hard”. We found eight PpARFs were more highly expressed in the “melting” peaches compared to “stony hard” peaches, while three PpARFs were more highly expressed in “stony hard” peaches. Among them, the expression difference of PpARF4, PpARF7 and PpARF12 was large, and their function in regulating fruit development and fruit quality was discussed. Our work provides a basis for further exploring the mechanisms underlying auxin regulated peach fruit ripening.
SNP marker development in Pinus sylvestris L. in stress-responsive genes characterized from Pinus cembra L. transcriptomes
Authors: Köbölkuti Zoltán A. , Tóth Endre Gy. , Jahn Daniela , Heinze Berthold , Höhn Mária 
Published: May 2020

AbstractMassively parallel sequencing of cDNA is an efficient route for generating sequence collections that represent expressed genes under different environmental control. The analysis of their sequence helps in developing molecular markers, such as SNPs, which represent a useful tool in detecting adaptive signals in populations. In this study novel PCR markers, based on stress responsive genes, were designed from the transcriptome of the haploxylon Swiss stone pine (Pinus cembra L.) and tested for SNPs in the diploxylon Scots pine (Pinus sylvestris L.). 84 primers were tested on P. sylvestris DNA samples originating from three different types of habitat. After sequencing and BLAST search of the amplified products, parts of 19 different candidate genes were analysed by considering the polymorphic sites, insertions/deletions as well as synonymous and non-synonymous SNPs. In a total of 3735 sites no indels, eight synonymous and 11 non-synonymous SNPs were found. By providing de novo molecular markers developed in P. cembra and tested for transferability in Scots pine, our results give support for the use of de novo markers targeting conserved regions across different pines. The SNPs detected may have important applications in further studies of adaptive genetic variation, providing tools to study relevant genes important in the long-term adaptation of pine species.
Evaluation of the Presence of Methane in Złoczew Lignite: Comparison with Other Lignite Deposits in Poland
Authors: Macuda Jan , Baran Paweł , Wagner Marian 
Published: May 2020

AbstractCatastrophic cases of methane explosion during exploratory drilling within the Bełchatów ortholignite deposit have led to testing for methane in other Polish ortholignite mining areas, as well as in the Złoczew deposit, where it is planned to begin mining operations. Initial tests have shown Złoczew lignite to have the highest methane content among the Polish deposits so far studied, comparable with lignite from the Bełchatów deposit, with a methane capacity in excess of 2.5 dcm3/kg at a pressure of 10 bar. Based on the computed values of the Langmuir constant, a determination was made of the quantity of methane that can be desorbed from a pressure of 10 bar to 1 bar, as well as the residual methane content. For all of the tested samples, the residual methane content is between 30 and 50% of the sorption capacity at a pressure of 10 bar. The thermal sorption equations were used to compute values of the limiting isosteric heat of adsorption. Higher values of the heat of adsorption at zero surface capacity may indicate the presence of a small quantity of micro-pores. In the case of the samples with the highest sorption capacity, the limiting isosteric heats of adsorption are low, indicating a low proportion of micro-pores in the lignite. This was confirmed by tests of nitrogen adsorption at 77 K. The proportion of micro-pores in the studied lignites is 2–3%, while the dominant pore fraction is the meso-pores, which in lignite from the Złoczew and Bełchatów deposits account for 50–66% of total pores. It is concluded that the significant adsorption of methane in the ortholignite occurs chiefly in meso-pores because of compression of the gas under increased orogenic pressure. A link is made between the higher methane-bearing capacity of the ortholignite deposits and the degree of gelification of the huminite components, based on simple statistical correlations between the methane sorption capacity and the content of humic gelified maceral. The results concerning methane sorption in lignite from the Złoczew deposit have enabled a preliminary classification of the methane-bearing capacity of Polish ortholignite deposits, which may also be of significance for similar deposits in other countries.
A survey of the European Society of Clinical Pharmacy members’ research involvement, and associated enablers and barriers
Authors: Stewart Derek , Paudyal Vibhu , Cadogan Cathal , Hazen Ankie , Okuyan Betul , Lutters Monika , Henman Martin , Fialová Daniella 
Published: May 2020

AbstractBackground Building research capacity of European Society of Clinical Pharmacy (ESCP) members aligns to the organisation’s aim of advancing research. Objective To determine members’ aspirations and needs in research training and practice, and to explore ways in which ESCP could provide support. Setting ESCP’s international membership. Method Cross-sectional survey of members in 2018, followed by focus groups with samples of respondents attending an ESCP symposium. Survey items were: research activities; interests, experience and confidence; and Likert statements on research conduct. Principal component analysis (PCA) clustering of Likert statements from a previous study was used, with scores for each component calculated. Focus groups discussed barriers to research and how ESCP could provide support. Data analysis involved collating and comparing all themes. Main outcome measures Research interest, experience and confidence; attitudinal items; barriers to research; ESCP support. Results The response rate was 16.7% (83/499), with 89.2% (n = 74) involved in research and 79.5% (n = 66) publishing research in the preceding 2 years. While overwhelmingly positive, responses were more positive for research interest than experience or confidence. PCA component scores (support/opportunities, motivation/outcomes, and roles/characteristics) were positive. Thirteen members participated in focus groups, identifying barriers of: insufficient collaboration; lack of knowledge, skills, training; unsupportive environment; insufficient time; and limited resources. ESCP could support through mentorship, collaboration, education and funding. Conclusion Study participants were highly active, interested, experienced, confident and positive regarding research. There is an opportunity for ESCP to harness these activities and provide support in the form of mentoring, education and training, and facilitating collaboration.
Stem taper functions for Betula platyphylla in the Daxing’an Mountains, northeast China
Authors: Shahzad Muhammad Khurram , Hussain Amna , Burkhart Harold E. , Li Fengri , Jiang Lichun 
Published: May 2020

AbstractAccurate prediction of stem diameter is an important prerequisite of forest management. In this study, an appropriate stem taper function was developed for upper stem diameter estimation of white birch (Betula platyphylla Sukaczev) in ten sub-regions of the Daxing’an Mountains, northeast China. Three commonly used taper functions were assessed using a diameter and height dataset comprising 1344 trees. A first-order continuous-time error structure accounted for the inherent autocorrelation. The segmented model of Max and Burkhart (For Sci 22:283–289, 1976. 10.1093/forestscience/22.3.283) and the variable exponent taper function of Kozak (For Chron 80:507–515, 2004. 10.5558/tfc80507-4) described the data accurately. Owing to its lower multicollinearity, the Max and Burkhart (1976) model is recommended for diameter estimation at specific heights along the stem for the ten sub-regions. After comparison, the Max and Burkhart (1976) model was refitted using nonlinear mixed-effects techniques. Mixed-effects models would be used only when additional upper stem diameter measurements are available for calibration. Differences in region-specific taper functions were indicated by the method of the non-linear extra sum of squares. Therefore, the particular taper function should be adjusted accordingly for each sub-region in the Daxing’an Mountains.
Lessons from mouse models of Graves’ disease
Authors: Eckstein A. , Philipp S. , Goertz G. , Banga J. P. , Berchner-Pfannschmidt U. 
Published: May 2020

AbstractGraves’ disease (GD) is an autoimmune condition with the appearance of anti-TSH receptor (TSHR) autoantibodies in the serum. The consequence is the development of hyperthyroidism in most of the patients. In addition, in the most severe cases, patients can develop orbitopathy (GO), achropachy and dermopathy. The central role of the TSHR for the disease pathology has been well accepted. Therefore immunization against the TSHR is pivotal for the creation of in vivo models for the disease. However, TSHR is well preserved among the species and therefore the immune system is highly tolerant. Many differing attempts have been performed to break tolerance and to create a proper animal model in the last decades. The most successful have been achieved by introducing the human TSHR extracellular domain into the body, either by injection of plasmid or adenoviruses. Currently available models develop the whole spectrum of Graves’ disease—autoimmune thyroid disease and orbitopathy and are suitable to study disease pathogenesis and to perform treatment studies. In recent publications new immunomodulatory therapies have been assessed and also diseaseprevention by inducing tolerance using small cyclic peptides from the antigenic region of the extracellular subunit of the TSHR.
Curcumin Loaded in Niosomal Nanoparticles Improved the Anti-tumor Effects of Free Curcumin on Glioblastoma Stem-like Cells: an In Vitro Study
Authors: Sahab-Negah Sajad , Ariakia Fatemeh , Jalili-Nik Mohammad , Afshari Amir R. , Salehi Sahar , Samini Fariborz , Rajabzadeh Ghadir , Gorji Ali 
Published: May 2020

AbstractUsing a novel curcumin-loaded niosome nanoparticle (CM-NP), the present study was designed to evaluate the effect of curcumin on human glioblastoma stem-like cells (GSCs). CM-NP has a diameter of ~ 60 nm and a zeta potential of ~ − 35 mV with a constant physicochemical stability. The cytotoxic effects of free curcumin (CM) and CM-NP were investigated on GSCs obtained during the removal of a brain tumor. Both CM and CM-NP caused a dose-dependent decrease in cell proliferation and viability of GSCs. The IC50 values of CM and CM-NP on GSCs were 50 and 137 μg/ml after 24 h, respectively. CM-NP exerted significantly higher effects on GSC viability, apoptosis, cell cycle arrest, and the expression of Bax, a pro-apoptotic marker, compared with CM. In addition, the migration of GSCs was significantly impaired following the administration of CM-NP compared with CM. Furthermore, CM-NP significantly increased the values of reactive oxygen species and decreased the mRNA expressions of NF-κB and IL-6 of GSCs compared with CM. Our data also revealed that CM-NP could significantly reduce the invasiveness of GSCs compared with CM, possibly via MCP-1-mediated pathways. In addition, CM-NP exhibited a significantly greater inhibitory effect on colony formation of GSCs compared with CM. These data indicate that CM-NP exhibited stronger anti-tumor effects on GSCs than CM. Although further in vivo investigations are warranted, our results suggest that CM-NP could be an ideal carrier to deliver curcumin for potential therapeutic approaches into glioblastoma.
Per se eine multiprofessionelle Profession?!
Authors: Korth Anna , Lux Anna-Lena , Schröer Wolfgang , Wagner Leonie 
Published: May 2020

ZusammenfassungIm Themenschwerpunkt wird die Auffassung vertreten, dass Soziale Arbeit in ihrem fachlichen Ansatz insbesondere auf Multiprofessionalität ausgelegt ist. Vor diesem Hintergrund soll daher der wesentlichen Frage nachgegangen werden, wie Multiprofessionalität in der sozialarbeiterischen Praxis konkret hergestellt wird. Hierfür werden mögliche Ausgestaltungsformen multiprofessionellen Handelns beispielhaft an vier ausgewählten Handlungsfeldern der Sozialen Arbeit illustriert.
Fine-tuning front-line therapy in chronic lymphocytic leukemia
Authors: Bohn Jan-Paul , Wolf Dominik 
Published: May 2020

SummaryA deeper understanding of disease biology and the advent of targeted drugs have implemented chemotherapy-free treatment options in chronic lymphocytic leukemia (CLL). With consistently superior outcome data and good tolerability, the Bruton’s kinase inhibitor ibrutinib as well as the B‑cell lymphoma 2 inhibitor venetoclax +/− CD20 antibody have recently been licensed for first-line treatment independently of TP53 status and are currently recommended as therapy of choice in most patient subgroups according to international management guidelines. Survival curves, however, have not reached a plateau and relapse due to acquired resistance or drug intolerance remain major hurdles in CLL treatment. Clinical trials currently focus on the most promising combinations and sequences of highly effective targeted drugs aimed at avoiding drug resistance by further enhancing eradication of minimal residual disease and optimizing drug tolerability. This brief review provides an update on the recently presented clinical trial data in first-line CLL at ASH 2019 and discusses clinically relevant obstacles to overcome.
Die SPD im Spagat zwischen Regierungsverantwortung und Überzeugung – Migration im parlamentarischen Parteienwettbewerb
Authors: Atzpodien Dana Siobhan 
Published: May 2020

ZusammenfassungDer vorliegende Beitrag analysiert die flüchtlings- und migrationspolitischen Reden des Deutschen Bundestags während der 18. Legislaturperiode und zeigt mithilfe des quantitativen Textanalyseinstruments Wordfish sowie einer umfangreichen qualitativen Validierung die Dynamiken des parlamentarischen Parteienwettbewerbs während der europäischen Flüchtlingskrise. Das dynamische Feld der Flüchtlings- und Migrationspolitik stellt die Parteien und insbesondere die Sozialdemokratische Partei Deutschlands (SPD) vor dem Hintergrund des liberalen Dilemmas sowie durch wechselnde Themenbetonung und daraus folgende Wettbewerbslogiken unter Druck. Die Position der SPD variierte im sonst stabilen parlamentarischen Wettbewerb deutlich, da sich die Partei in einem Spagat zwischen ihrer formalen Regierungsverantwortung und ihrer ideologischen Positionierung befand.
Impacts of farmer field schools in the human, social, natural and financial domain: a qualitative review
Authors: van den Berg Henk , Phillips Suzanne , Dicke Marcel , Fredrix Marjon 
Published: May 2020

AbstractThe Farmer Field School (FFS) is a widely used method seeking to educate farmers to adapt agricultural decisions to diverse and variable field conditions. Out of 218 screened studies, 65 were selected to review the impact of the FFS. An analytical framework was developed with effects (outputs, outcomes and impacts) arranged according to the human, social, natural and financial domains. Impacts on non-participants of the FFS were addressed as peripheral effects. The FFS demonstrated its potential to enhance human, social, natural and financial capital of rural communities. Human capital was built in the form of critical thinking, innovation, confidence, and quality of life. Effects on social capital included mutual trust, bonding, collective action, networking, and emancipation. Natural capital was enhanced through improvements in field practices, food production, agricultural diversification, and food security. Financial capital was enhanced through increased income and profits, savings and loans schemes, with a potential to reduce poverty. The available body of evidence was unbalanced across the capital domains, providing high coverage of the natural domain but low coverage of the human, social and financial domains. In-depth case studies are needed to elucidate the interactions between livelihood assets, and the influences of the policy, institutional and external environment, in order to adjust FFS interventions aiming to optimize their impacts. Considering the positive effects the FFS can have on rural livelihoods, the FFS has potential to contribute to achieving the Sustainable Development Goals. However, quality assurance of the FFS and a balanced evaluation across the capital domains require attention.
Son Preference and Fertility Decisions: Evidence From Spatiotemporal Variation in Korea
Authors: Kim Seik , Lee Sam-Ho 
Published: May 2020

Abstract
Using Korean data, this study investigates whether son-favoring ideas or the preference for sons affect fertility decisions. Son-favoring fertility behavior in Korea is of interest because the sex ratio at birth has recovered to a natural level after having been very skewed. To isolate the effects of the preference for sons from the effects of the surrounding environment, we compare the fertility behavior of individuals living in the same region but who were born in different regions or years. Exploiting the male-female gap in educational achievement at the parents’ time and place of birth as exogenous variation in the 2000 Census Korea 2% sample, we find that the strength of son preference formed at an early age is associated with the strength of son-favoring fertility behavior as adults. Our results indicate that parents are more likely to have a third child if they happen to have only daughters as their first two children. More importantly, this tendency is stronger if parents were born in a spatiotemporal region with more skewed gender gap in educational investment. These findings are robust against various alternative specifications, including endogenous migration issues.
Living Arrangements and Supplemental Income Programs for Older Adults in Mexico
Authors: Aguila Emma , Park Jung Ho , Vega Alma 
Published: May 2020

AbstractLiving arrangements often reflect important quality-of-life indicators for elderly adults. In particular, increased income can prompt changes in household living arrangements for elderly adults. Using a differences-in-differences approach, we examine whether a supplemental income program in Mexico for adults aged 70 and older influenced household size and composition. We compare outcomes at baseline and at six-month follow-up for elderly adults in the treatment group with those in the control group that did not participate in the program. We find that household size increased by 3% in the treatment group relative to the control group. We also find a statistically significant increase in the number of girls aged 6–11 in the household, likely the granddaughters or great-granddaughters of program recipients. Increases in household size were greatest for adults aged 70–79, couples, households receiving two or more supplemental incomes, and households in the top income tercile. Household size did not increase for households of adults aged 80 and older, singles, households with only one supplemental income recipient, and households not in the top income tercile. These results suggest that when older adults have more income, they use part of this income to house their grandchildren.
Words matter: Translanguaging in medical communication skills training
Authors: Ortega Pilar , Prada Josh 
Published: May 2020

Medical communication across languages is gaining attention as the multilingual character of local, regional, and national populations across the world continues to grow. Effectively communicating with patients involves not only learning medical terminology, but also understanding the community’s linguistic practices, and gaining the ability to explain health concepts in patient-centered language. Language concordance between physicians and patients improves patient outcomes, but methods to teach communication skills for physicians are usually limited to the majority or official language. For example, in U.S. medical schools increased demand for physician skills in other languages, such as Spanish, has resulted in renewed academic discourse about best practices in teaching practical communication skills for physicians. In language education, translanguaging is an approach that integrates and validates multilingual individuals’ real use of language, which often includes non-standard words, regionalisms, and mixed influences from multiple languages, such as Spanglish or Chinglish. Efforts to improve medical language concordance by teaching a second language to medical students would benefit from an understanding of patient-centered communication strategies, such as is supported by translanguaging. Teaching effective communication skills to physicians should evolve and engage with the fluid linguistic attributes of culturally and linguistically diverse patient populations. In this eye opener, we first introduce the translanguaging perspective as an approach that can increase attention to patient-centered communication, which often includes spontaneous practices that transcend the traditional boundaries of named languages, and then present examples of how translanguaging can be implemented in medical education in order to sustainably enhance equity-minded patient-accessible medical communication.