bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bounded Geometry and p-Harmonic Functions Under Uniformization and Hyperbolization
Authors: Björn Anders , Björn Jana , Shanmugalingam Nageswari 
Published: July 2020

AbstractThe uniformization and hyperbolization transformations formulated by Bonk et al. in“Uniformizing Gromov Hyperbolic Spaces”, Astérisque, vol 270 (2001), dealt with geometric properties of metric spaces. In this paper we consider metric measure spaces and construct a parallel transformation of measures under the uniformization and hyperbolization procedures. We show that if a locally compact roughly starlike Gromov hyperbolic space is equipped with a measure that is uniformly locally doubling and supports a uniformly localp-Poincaré inequality, then the transformed measure is globally doubling and supports a globalp-Poincaré inequality on the corresponding uniformized space. In the opposite direction, we show that such global properties on bounded locally compact uniform spaces yield similar uniformly local properties for the transformed measures on the corresponding hyperbolized spaces. We use the above results on uniformization of measures to characterize when a Gromov hyperbolic space, equipped with a uniformly locally doubling measure supporting a uniformly localp-Poincaré inequality, carries nonconstant globally definedp-harmonic functions with finitep-energy. We also study some geometric properties of Gromov hyperbolic and uniform spaces. While the Cartesian product of two Gromov hyperbolic spaces need not be Gromov hyperbolic, we construct an indirect product of such spaces that does result in a Gromov hyperbolic space. This is done by first showing that the Cartesian product of two bounded uniform domains is a uniform domain.
Awake breast cancer surgery: strategy in the beginning of COVID-19 emergency
Authors: Vanni Gianluca , Pellicciaro Marco , Materazzo Marco , Dauri Mario , D’angelillo Rolando Maria , Buonomo Chiara , De Majo Adriano , Pistolese Chiara , Portarena Ilaria , Mauriello Alessandro , Servadei Francesca , Giacobbi Erica , Chiaravalloti Agostino , Buonomo Oreste Claudio 
Published: July 2020

Abstract
Introduction
COVID-19 is a declared worldwide pandemic. In our country, due to shortage of hospitals and beds in intensive care unit, oncological and breast cancer (BC) resources are temporarily shifted to COVID-19 patients. In addition, risk of cross-infections should be considered in these frail patients. To accomplish more surgical procedures and to reduce the length of hospital stay (LOS), fast track awake BC surgery should be implemented. The aim of the study is to estimate the effects of surgical shift in our facility during the early COVID-19 outbreak.

Materials and methods
From 30th January 2020 to 30th of March 2020, 86 consecutive patients were retrospectively enrolled and divided into pre-COVID-19-BC and COVID-19-BC. Clinical parameters and anamnestic data were collected and analyzed. Surgical procedures, relative complications and type of anaesthesia were reported. The effect on surgical time (ST), operative room time (ORT) and length of stay (LOS) were described and examined.

Results
No statistical difference was found in complications rate, clinical data and surgical procedures (p > 0.05). Awake breast conservative surgery (BCS) was the most frequent procedure in COVID-19-BC (p = 0.006). A statistically significant decrease in ORT and LOS was reported in COVID-19-BC (p = 0.040 and p = 0.0015 respectively), while comparable time resulted for ST (p = 0.976). Mean ORT and LOS reduction were 20.79 min and 0.57 hospital bed days.

Conclusion
In the “COVID-19 era”, fast track awake breast surgery provides a reduction of ORT, LOS and potentially surgical treatment for a wider number of oncological patients.
Environment and human subsistence in Northern France at the Late Glacial to early Holocene transition
Authors: Drucker Dorothée G. , Bridault Anne , Ducrocq Thierry , Baumann Chris , Valentin Frédérique 
Published: July 2020

AbstractThe Late Glacial and early Holocene (ca. 15,000–6,000 cal BP) witnessed major changes in the environmental conditions which led to the establishment of temperate vegetation and animal species, thereby offering new subsistence opportunities to the population of hunter-gatherers. Measurements of the relative abundances in 13C and 15N were applied to large herbivores from northern France to document the change in their habitat. During the early Holocene, red deer show a decrease in δ13C values most likely reflecting the effect of a dense canopy and an increase in δ15N values probably linked to the increased soil activity of soils in foraged territories. Aurochs and roe deer δ13C values also revealed a more densely forested habitat at the end of the Preboreal, while the δ13C values of the wild boar indicate dependence on fruits and underground tubers that were not affected by the canopy effect. Three human individuals from Val-de-Reuil and La Chaussée-Tirancourt dated to the Preboreal period provided relatively high δ15N values when compared with the local fauna and other early Mesolithic humans, which might have resulted from the consumption of freshwater resources especially at Val-de-Reuil. The δ34S values appear to depend more on the geographical location of the individual, as demonstrated by the difference among wild boar δ34S values between sites, rather than related to the protein source of the diet, namely, terrestrial versus aquatic. Our results confirm the influence of the forest ecosystem on the environment and diet of the considered early Mesolithic human of northern France, while the possible contribution of the aquatic ecosystem still needs to be documented.
Machine learning prediction of susceptibility to visceral fat associated diseases
Authors: Aldraimli M. , Soria D. , Parkinson J. , Thomas E. L. , Bell J. D. , Dwek M. V. , Chaussalet T. J. 
Published: July 2020

AbstractClassifying subjects into risk categories is a common challenge in medical research. Machine Learning (ML) methods are widely used in the areas of risk prediction and classification. The primary objective of such algorithms is to use several features to predict dichotomous responses (e.g., healthy/at risk). Similar to statistical inference modelling, ML modelling is subject to the problem of class imbalance and is affected by the majority class, increasing the false-negative rate. In this study, we built and evaluated thirty-six ML models to classify approximately 4300 female and 4100 male participants from the UK Biobank into three categorical risk statuses based on discretised visceral adipose tissue (VAT) measurements from magnetic resonance imaging. We also examined the effect of sampling techniques on the models when dealing with class imbalance. The sampling techniques used had a significant impact on the classification and resulted in an improvement in risk status prediction by facilitating an increase in the information contained within each variable. Based on domain expert criteria the best three classification models for the female and male cohort visceral fat prediction were identified. The Area Under Receiver Operator Characteristic curve of the models tested (with external data) was 0.78 to 0.89 for females and 0.75 to 0.86 for males. These encouraging results will be used to guide further development of models to enable prediction of VAT value. This will be useful to identify individuals with excess VAT volume who are at risk of developing metabolic disease ensuring relevant lifestyle interventions can be appropriately targeted.
COVID-19 what have we learned? The rise of social machines and connected devices in pandemic management following the concepts of predictive, preventive and personalized medicine
Authors: Radanliev Petar , De Roure David , Walton Rob , Van Kleek Max , Montalvo Rafael Mantilla , Santos Omar , Maddox La’Treall , Cannady Stacy 
Published: July 2020

Abstract
Objectives
Review, compare and critically assess digital technology responses to the COVID-19 pandemic around the world. The specific point of interest in this research is on predictive, preventive and personalized interoperable digital healthcare solutions. This point is supported by failures from the past, where the separate design of digital health solutions has led to lack of interoperability. Hence, this review paper investigates the integration of predictive, preventive and personalized interoperable digital healthcare systems. The second point of interest is the use of new mass surveillance technologies to feed personal data from health professionals to governments, without any comprehensive studies that determine if such new technologies and data policies would address the pandemic crisis.

Method
This is a review paper. Two approaches were used: A comprehensive bibliographic review with R statistical methods of the COVID-19 pandemic in PubMed literature and Web of Science Core Collection, supported with Google Scholar search. In addition, a case study review of emerging new approaches in different regions, using medical literature, academic literature, news articles and other reliable data sources.

Results
Most countries’ digital responses involve big data analytics, integration of national health insurance databases, tracing travel history from individual’s location databases, code scanning and individual’s online reporting. Public responses of mistrust about privacy data misuse differ across countries, depending on the chosen public communication strategy. We propose predictive, preventive and personalized solutions for pandemic management, based on social machines and connected devices.

Solutions
The proposed predictive, preventive and personalized solutions are based on the integration of IoT data, wearable device data, mobile apps data and individual data inputs from registered users, operating as a social machine with strong security and privacy protocols. We present solutions that would enable much greater speed in future responses. These solutions are enabled by the social aspect of human-computer interactions (social machines) and the increased connectivity of humans and devices (Internet of Things).

Conclusion
Inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping COVID-19 and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. We present a summary of predictive, preventive and personalized digital methods that could be deployed fast to help with the COVID-19 and future pandemics.
Harmonising, improving and using social and recreational data in National Forest Inventories across Europe
Authors: Atkinson Mark A. , Edwards David M. , Jensen Frank Søndergaard , van der Jagt Alexander P. N. , Ditchburn Ben R. , Sievänen Tuija , Gasparini Patrizia 
Published: July 2020

Abstract
Key message

National Forest Inventories (NFIs) hold promise for monitoring and valuing of non-productive forest functions, including social and recreational services. European countries use a range of methods to collect social and recreational information within their NFI methodologies. Data collected frequently included general and recreation-specific infrastructure, but innovative approaches are also used to monitor recreational use and social abuse.

Context
Social and recreational indicators are increasingly valued in efforts to measure the non-productive value of forests in Europe. National Forest Inventories (NFIs) can be used to estimate recreational and social usage of forest land at a national level and relate this use to other biophysical, spatial and topographical features. Nonetheless, there is little information concerning the extent.

Aims
The study aims to identify the coverage of social and recreational data present in European NFIs including the types of data recorded as part of the NFI methodologies across European countries. It also aims to examine contrasting methods used to record social and recreational data and present recommendations for ways forward for countries to integrate these into NFI practice.

Methods
A pan-European questionnaire was designed and distributed to 35 counties as part of the EU-funded project Distributed, Integrated and Harmonised Forest Information for Bioeconomy Outlooks (DIABOLO). The questionnaire probed countries on all social and recreational data that was included within NFIs. Qualitative response data was analysed and recoded to measure the extent of social and recreational data recoded in European NFIs both as a function of the number of variable categories per country and the number of countries recording particular variables.

Results
Thirty-one countries reported at least one social or recreational variable over 12 categories of data. The most frequently recorded variables included ownership, general transport infrastructure and recreation-specific infrastructure. Countries collecting data over many different categories included Switzerland, Great Britain, Czech Republic, Luxemburg and Denmark.

Conclusion
The study proposes a specific set of indicators, based upon countries with well-developed social and recreational data in their NFIs, which could be used by other countries, and report on the extent to which these are currently collected across Europe. It discusses results and makes a series of recommendations concerning priorities for the inclusion of social and recreational data in European NFIs.
A new approach to evaluate linear programming problem in pentagonal neutrosophic environment
Authors: Das Sapan Kumar , Chakraborty Avishek 
Published: July 2020

AbstractIn this paper, authors disclose a new concept of pentagonal neutrosophic (PN) approach to solve linear programming (LP) problem. To best of our insight, there is no approach for solving PNLP problem. For the first time, we take up the PNLP problem where the objectives, constraints are considered as pentagonal neutrosophic numbers (PNN). To deign our algorithm, we described the PN arithmetic operation laws and mathematical computation in PNN environment. This proposed method is based on ranking function and convert to its equivalent crisp LP (CrLP) problem. The obtained CrLP issue is presently being tackled by any LP method which is effectively accessible. To legitimize the proposed technique, some numerical tests are given to show the adequacy of the new model.
A Simple, Centrifugation-Free, Sperm-Sorting Device Eliminates the Risks of Centrifugation in the Swim-Up Method While Maintaining Functional Competence and DNA Integrity of Selected Spermatozoa
Authors: Meitei Huidrom Yaiphaba , Uppangala Shubhashree , Sharan Krishna , Chandraguthi Srinidhi Gururajarao , Radhakrishnan Arunkumar , Kalthur Guruprasad , Schlatt Stefan , Adiga Satish Kumar 
Published: July 2020

AbstractThis pilot study was conducted to explore the benefits of using a centrifugation-free device based on the migration–sedimentation (MS) technique over centrifugation-based techniques in selecting competent spermatozoa, as compared with using split human semen samples. Ejaculates from 35 men undergoing semen analysis were split into four parts where one part was retained as the neat (NE) and the other three parts were subjected to sperm selection by using migration–sedimentation (MS), density gradient (DG) separation, and swim-up (SU) techniques. Sperm functional characteristics along with mitochondrial integrity, tyrosine phosphorylation, acrosome reaction, and ultrastructure were measured. The ability of selection techniques in reducing spontaneous and radiation-induced sperm DNA lesions was assessed by the TUNEL assay. In results, MS-selected spermatozoa had higher viability (P < 0.001), longevity in terms of total motility at the end of 6 and 18 h post-extraction (P < 0.001), and mitochondrial integrity (P < 0.001) compared with those selected by DG. Furthermore, spontaneous DNA lesions were significantly reduced in MS and SU fractions compared with NE (P < 0.001). Similarly, radiation-induced sperm DNA lesions were significantly lower in MS and SU fractions (P < 0.001) compared with DG. Ultrastructural analysis using scanning electron microscopy suggested a moderate, non-significant increase in the number of spermatozoa with normal head and mid-piece in MS fraction compared with other methods. In conclusion, the MS-based device offers a centrifugation-free, efficient, and reliable sperm selection method, making it suitable for partially equipped intra-uterine insemination (IUI) laboratories or office IUI programmes. Further research should focus on the safety and clinical usefulness of the device in assisted conception programmes in general and IUI in specific.
Clinicopathological Significance of Common Genetic Alterations in Patients With Acute Promyelocytic Leukemia
Authors: Nath Sukanta , Bhattacharyya Jina , Chandra Prem , Saxena Renu , Sazawal Sudha , Saikia Kandarpa Kumar 
Published: July 2020

Objective/Background:
Acute myeloid leukemia (AML) is one of the common forms of hematological malignancy and acute promyelocytic leukemia (APL) is a unique subtype of AML conferring favorable prognosis. We aimed to determine the prevalence and prognostic impact of Fms-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1) mutation, epidermal growth factor receptor (EGFR), and flow marker’s expression in patients with APL.

Methods:
In the present study, 165 de novo APL patients were molecularly characterized for promyelocytic leukemia (PML) breakpoint and additional genetic alterations. Reverse transcriptase polymerase chain reaction (PCR) and realtime PCR assays were used to detect genetic alterations.

Results:

PML/RARa was detected in 29/165 (17.5%) samples with breakpoint cluster region 1 (bcr1) in 17/29 (58.5%) and bcr3 in 12/29 (41.5%) samples. The prevalence of FLT3-ITD, NPM1, and EGFR were detected in 5/29 (17.5%), 11/29 (38%), and 5/29 (17.5%) patients, respectively. Patients expressing bcr-3 hybrid transcript had lower overall survival compared with bcr1 (p = .254). White blood cell (WBC) count was significantly higher in bcr3 in comparison with bcr1 patients (p = .002). Patients with positive EGFR expression (p = .042) and higher WBC (p = .002) were significantly associated with poor survival (p < .05).

Conclusions:
We documented the higher prevalence of bcr1 and confirmed that the association of FLT3-ITD significantly reduced the chances of survival in APL. The mortality rate of bcr3 was comparatively higher than that of bcr1. Higher WBC count and EGFR expression were significantly associated with poor survival.
Presidential Instability in Latin America: Why Institutionalized Parties Matter
Authors: Martínez Christopher A. 
Published: July 2020

AbstractPedro P. Kuczynski (Peru 2018) and Evo Morales (Bolivia 2019) are the most recent cases in a long list of Latin American presidents who have been forced out of office. We seek to contribute to understanding why some presidents fail to fulfil their terms by analysing the role of an actor overlooked by the extant literature on presidential failures: political parties. We hypothesize a non-linear relation between party institutionalization and the risk of presidential failure. That is, when parties are weakly or highly institutionalized, the hazard of presidential failure is lower than when parties are moderately institutionalized. We test this and other hypotheses with a survival analysis of 157 Latin American administrations (1979–2018). We also qualitatively explore how the occurrence (or non-occurrence) of certain events affects the risk of failure in three countries with different levels of party institutionalization. We find that party institutionalization – as well as legislative support, anti-government demonstrations, presidential scandals and economic growth – significantly affects the risk of presidential failure.
Posttraumatic stress symptomatology and abnormal neural responding during emotion regulation under cognitive demands: mediating effects of personality
Authors: Sun Michael , Marquardt Craig A. , Disner Seth G. , Burton Philip C. , Davenport Nicholas D. , Lissek Shmuel , Sponheim Scott R. 
Published: July 2020

AbstractPosttraumatic stress disorder (PTSD) is often complicated by the after-effects of mild traumatic brain injury (mTBI). The mixture of brain conditions results in abnormal affective and cognitive functioning, as well as maladaptive behavior. To better understand how brain activity explains cognitive and emotional processes in these conditions, we used an emotional N-back task and functional magnetic resonance imaging (fMRI) to study neural responses in US military veterans after deployments to Iraq and Afghanistan. Additionally, we sought to examine whether hierarchical dimensional models of maladaptive personality could account for the relationship between combat-related brain conditions and fMRI responses under cognitive and affective challenge. FMRI data, measures of PTSD symptomatology (PTSS), blast-induced mTBI (bmTBI) severity, and maladaptive personality (MMPI-2-RF) were gathered from 93 veterans. Brain regions central to emotion regulation were selected for analysis, and consisted of bilateral amygdala, bilateral dorsolateral prefrontal (dlPFC), and ventromedial prefrontal/subgenual anterior cingulate (vmPFC-sgACC). Cognitive load increased activity in dlPFC and reduced activity in emotional responding brain regions. However, individuals with greater PTSS showed blunted deactivations in bilateral amygdala and vmPFC-sgACC, and weaker responses in right dlPFC. Additionally, we found that elevated emotional/internalizing dysfunction (EID), specifically low positive emotionality (RC2), accounted for PTSS-related changes in bilateral amygdala under increased cognitive load. Findings suggest that PTSS might result in amygdala and vmPFC-sgACC activity resistant to moderation by cognitive demands, reflecting emotion dysregulation despite a need to marshal cognitive resources. Anhedonia may be an important target for interventions that improve the affective and cognitive functioning of individuals with PTSD.
THE VIEW FROM OLYMPUS: THE MUSES’ SONG IN THEHOMERIC HYMN TO APOLLO
Authors: Spelman Henry L. 
Published: July 2020

Apollo travels from Pytho to Olympus, and the other gods greet his arrival (186–93):ἔνθεν δὲ πρὸϲ Ὄλυμπον ἀπὸ χθονὸϲ ὥϲ τε νόημαεἶϲι Διὸϲ πρὸϲ δῶμα θεῶν μεθ’ ὁμήγυριν ἄλλων⋅αὐτίκα δ’ ἀθανάτοιϲι μέλει κίθαριϲ καὶ ἀοιδή.Μοῦϲαι μέν θ’ ἅμα πᾶϲαι ἀμειβόμεναι ὀπὶ καλῇὑμνεῦϲίν ῥα θεῶν δῶρ’ ἄμβροτα ἠδ’ ἀνθρώπωντλημοϲύναϲ, ὅϲ’ ἔχοντεϲ ὑπ’ ἀθανάτοιϲι θεοῖϲιζώουϲ’ ἀφραδέεϲ καὶ ἀμήχανοι, οὐδὲ δύνανταιεὑρέμεναι θανάτοιό τ’ ἄκοϲ καὶ γήραοϲ ἄλκαρ.From there he goes quick as a thought from the earth to Olympus, to the house of Zeus, in order to join the gathering of the other gods. Immediately the immortals concern themselves with lyre music and song. All the Muses together, responding with their beautiful voice, hymn the divine gifts of the gods and the endurance of men, all that they have from the immortal gods and yet live ignorant and helpless, unable to find a remedy for death and a defence against old age.