bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correction of severe valgus osteoarthritis by total knee arthroplasty is associated with increased postoperative ankle symptoms
Authors: Graef Frank , Hommel Hagen , Falk Roman , Tsitsilonis Serafeim , Zahn Robert Karl , Perka Carsten 
Published: August 2020

Abstract
Purpose
The aim of this study was to assess the mid-term clinical outcome of the ankle joint after total knee arthroplasty (TKA) in high-grade valgus osteoarthritis.

Methods
In this case–control study, n = 36 patients with a preoperative mechanical tibiofemoral angle (mTFA) ≥ 15° who underwent TKA between December 2002 and December 2012 were included. The control group (mTFA < 15°) of n = 60 patients was created using case matching. Radiological [mechanical tibiofemoral angle (mTFA) and ankle joint orientation to the ground (G-AJLO)] and clinical parameters [Foot Function Index (FFI), Knee Society Score, Forgotten Joint Score, and Range of Motion (ROM)] were analysed. The mean follow-up time was 59 months (IQR [56, 62]).

Results
The degree of correcting the mTFA by TKA significantly correlated with the postoperative FFI (R = 0.95, p < 0.05), although the knee and ankle joint lines were corrected to neutral orientations. A cut-off value of 16.5° [AUC 0.912 (0.85–0.975 95% CI), sensitivity = 0.8, specificity = 0.895] was calculated, above which the odds ratio (OR) for developing ankle symptoms increased vastly [OR 34.0 (9.10–127.02 95% CI)]. ROM restrictions of the subtalar joint displayed a strong significant correlation with the FFI (R = 0.74, p < 0.05), demonstrating that decreased ROM of the subtalar joint was associated with aggravated outcomes of the ankle joint.

Conclusions
In this study, higher degrees of leg axis correction in TKA were associated with increased postoperative ankle symptoms. When TKA is performed in excessive valgus knee osteoarthritis, surgeons should be aware that this might trigger the onset or progression of ankle symptoms, particularly in cases of a stiff subtalar joint.

Level of evidence
III.
Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019
Authors: Gustafson Emma , Debruyne Christophe , De Troyer Olga , Rogiers Vera , Vinken Mathieu , Vanhaecke Tamara 
Published: August 2020

AbstractA focal point in the safety evaluation of cosmetic ingredients includes oral repeated dose toxicity testing, which is intended to address the most complex human endpoints. Seven years after the full implementation of the animal testing ban for cosmetic ingredients in the EU, there are still no alternative methods available capable of fully replacing oral repeated dose toxicity testing. Until this issue is resolved, the development of new cosmetic ingredients remains seriously hampered. The present paper describes a thorough screening of the oral repeated dose toxicity data included in safety evaluation reports of cosmetic ingredients addressed in the Annexes of the Cosmetics Regulation (EC) No 1223/2009, issued by the Scientific Committee on Consumer Safety between 2009 and 2019. The liver and the haematological system were identified as the potentially most frequently affected organs upon oral administration of cosmetic ingredients to animals. Evaluation of altered biochemical, morphological, and histopathological parameters related to hepatotoxicity indicated that the most recurrent events are liver weight changes, elevated liver enzymes, and alterations in serum cholesterol and bilirubin levels. Combined listing of affected parameters associated with steatosis and cholestasis indicated the possible occurrence of cholestasis, provoked by a limited number of cosmetic ingredients. The most frequently affected parameters related to the haematological system were indicative of anaemia. An in-depth analysis allowed characterisation of both regenerative and non-regenerative anaemia, pointing to direct and indirect haematotoxicity, respectively. The results presented in this study call for prioritisation of research targeted towards the development of new approach methodologies fit for animal-free repeated dose toxicity evaluation of cosmetic ingredients.
Efficient algorithms for solving the p-Laplacian in polynomial time
Authors: Loisel Sébastien 
Published: August 2020

AbstractThe p-Laplacian is a nonlinear partial differential equation, parametrized by $$p \in [1,\infty ]$$

p
∈
[
1
,
∞
]

. We provide new numerical algorithms, based on the barrier method, for solving the p-Laplacian numerically in $$O(\sqrt{n}\log n)$$

O
(

n

log
n
)

Newton iterations for all $$p \in [1,\infty ]$$

p
∈
[
1
,
∞
]

, where n is the number of grid points. We confirm our estimates with numerical experiments.
Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation
Authors: Arponen Milja , Brockmann Eeva-Christine , Kiviranta Riku , Lamminmäki Urpo , Ivaska Kaisa K. 
Published: August 2020

AbstractOsteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Uncarboxylated osteocalcin (ucOC) may participate in the regulation of glucose metabolism, thus measurement of ucOC could be useful in evaluating interactions between bone and glucose metabolism. We developed recombinant antibodies and immunoassay to specifically detect ucOC in human blood samples. ucOC-specific recombinant antibodies were selected from an antibody library by phage display. Four candidates were characterized, and one (Fab-AP13) was used to set up an immunoassay with a pre-existing MAb. Plasma ucOC levels were measured in subjects with normal fasting blood glucose (≤ 6 mmol/l,N = 46) or with hyperglycemia (≥ 7 mmol/l,N = 29). Further, we analyzed ucOC in age- and gender-matched patients with diagnosed type 2 diabetes (T2D,N = 49). Antibodies recognized ucOC without cross-reaction to carboxylated osteocalcin. Antibodies had unique binding sites at the carboxylation region, with Glu17 included in all epitopes. Immunoassay was set up and characterized. Immunoassay detected ucOC in serum and plasma, with on average 1.6-fold higher levels in plasma. ucOC concentrations were significantly lower in subjects with hyperglycemia (median 0.58 ng/ml,p = 0.008) or with T2D diagnosis (0.68 ng/ml,p = 0.015) than in subjects with normal blood glucose (1.01 ng/ml). ucOC negatively correlated with fasting plasma glucose in subjects without T2D (r = − 0.24,p = 0.035) but not in T2D patients (p = 0.41). Our immunoassay, based on the novel recombinant antibody, allows for specific and sensitive detection of ucOC in human circulation. Correlation between ucOC and plasma glucose suggests interactions between osteocalcin and glucose metabolism in humans.
Mustafin varieties, moduli spaces and tropical geometry
Authors: Hahn Marvin Anas , Li Binglin 
Published: August 2020

AbstractMustafin varieties are flat degenerations of projective spaces, induced by a set of lattices in a vector space over a non-archimedean field. They were introduced by Mustafin (Math USSR-Sbornik 34(2):187, 1978) in the 70s in order to generalise Mumford’s groundbreaking work on the unformisation of curves to higher dimension. These varieties have a rich combinatorial structure as can be seen in pioneering work of Cartwright et al. (Selecta Math 17(4):757–793, 2011). In this paper, we introduce a new approach to Mustafin varieties in terms of images of rational maps, which were studied in Li (IMRN, 2017). Applying tropical intersection theory and tropical convex hull computations, we use this method to give a new combinatorial description of the irreducible components of the special fibers of Mustafin varieties. Finally, we outline a first application of our results in limit linear series theory.
Sentinel lymph node detection in oral cancer: a within-patient comparison between [99mTc]Tc-tilmanocept and [99mTc]Tc-nanocolloid
Authors: den Toom Inne J. , Mahieu Rutger , van Rooij Rob , van Es Robert J. J. , Hobbelink Monique G. G. , Krijger Gerard C. , Tijink Bernard M. , de Keizer Bart , de Bree Remco 
Published: August 2020

Abstract
Purpose
Sentinel lymph node (SLN) biopsy has proven to reliably stage the clinically negative neck in early-stage oral squamous cell carcinoma (OSCC). [99mTc]Tc-tilmanocept may be of benefit in OSCC with complex lymphatic drainage patterns and close spatial relation to SLNs.

Methods
A prospective within-patient evaluation study was designed to compare [99mTc]Tc-tilmanocept with [99mTc]Tc-nanocolloid for SLN detection. A total of 20 patients with early-stage OSCC were included, who underwent lymphoscintigraphy with both tracers. Both lymphoscintigraphic images of each patient were evaluated for SLN detection and radiotracer distribution at 2–4 h post-injection.

Results
The injection site’s remaining radioactivity was significantly lower for [99mTc]Tc-tilmanocept (29.9%), compared with [99mTc]Tc-nanocolloid (60.9%; p < 0.001). Radioactive uptake in SLNs was significantly lower for [99mTc]Tc-tilmanocept (1.95%) compared with [99mTc]Tc-nanocolloid (3.16%; p = 0.010). No significant difference was seen in SLN to injection site ratio in radioactivity between [99mTc]Tc-tilmanocept (0.066) and [99mTc]Tc-nanocolloid (0.054; p = 0.232). A median of 3.0 and 2.5 SLNs were identified with [99mTc]Tc-tilmanocept and [99mTc]Tc-nanocolloid, respectively (p = 0.297). Radioactive uptake in higher echelon nodes was not significantly different between [99mTc]Tc-tilmanocept (0.57%) and [99mTc]Tc-nanocolloid (0.86%) (p = 0.052). A median of 2.0 and 2.5 higher echelon nodes was identified with [99mTc]Tc-tilmanocept and [99mTc]Tc-nanocolloid, respectively (p = 0.083).

Conclusion
[99mTc]Tc-tilmanocept had a higher injection site clearance, but at the same time a lower uptake in the SLN, resulting in an SLN to injection site ratio, which was not significantly different from [99mTc]Tc-nanocolloid. The relatively low-radioactive uptake in SLNs of [99mTc]Tc-tilmanocept may limit intraoperative detection of SLNs, but can be overcome by a higher injection dose.
Involvement of radiologists in oncologic multidisciplinary team meetings: an international survey by the European Society of Oncologic Imaging
Authors: Neri Emanuele , Gabelloni Michela , Bäuerle Tobias , Beets-Tan Regina , Caruso Damiano , D’Anastasi Melvin , Dinkel Julien , Fournier Laure S , Gourtsoyianni Sofia , Hoffmann Ralf-Thorsten , Mayerhöfer Marius Erik , Regge Daniele , Schlemmer Heinz Peter , Laghi Andrea 
Published: August 2020

Abstract
Objectives
Multidisciplinary tumour boards (MTBs) play an increasingly important role in managing cancer patients from diagnosis to treatment. However, many problems arise around the organisation of MTBs, both in terms of organisation-administration and time management. In this context, the European Society of Oncologic Imaging (ESOI) conducted a survey among its members, aimed at assessing the quality and amount of involvement of radiologists in MTBs, their role in it and related issues.

Methods
All members were invited to fill in a questionnaire consisting of 15 questions with both open and multiple-choice answers. Simple descriptive analyses and graphs were performed.

Results
A total of 292 ESOI members in full standing for the year 2018 joined the survey. Most respondents (89%) declared to attend MT-Bs, but only 114 respondents (43.9%) review over 70% of exams prior to MTB meetings, mainly due to lack of time due to a busy schedule for imaging and reporting (46.6%). Perceived benefits (i.e. surgical and histological feedback (86.9%), improved knowledge of cancer treatment (82.7%) and better interaction between radiologists and referring clinicians for discussing rare cases (56.9%)) and issues (i.e. attending MTB meetings during regular working hours (71.9%) and lack of accreditation with continuing medical education (CME) (85%)) are reported.

Conclusions
Despite the value and benefits of radiologists’ participation in MTBs, issues like improper preparation due to a busy schedule and no counterpart in CME accreditation require efforts to improve the role of radiologists for a better patient care.

Key Points
• Most radiologists attend multidisciplinary tumour boards, but less than half of them review images in advance, mostly due to time constraints.
• Feedback about radiological diagnoses, improved knowledge of cancer treatment and interaction with referring clinicians are perceived as major benefits.
• Concerns were expressed about scheduling multidisciplinary tumour boards during regular working hours and lack of accreditation with continuing medical education.
Insulitis and lymphoid structures in the islets of Langerhans of a 66-year-old patient with long-standing type 1 diabetes
Authors: Smeets Silke , Staels Willem , Stangé Geert , Gillard Pieter , De Leu Nico , in’t Veld Peter 
Published: August 2020

AbstractInsulitis is a characteristic inflammatory lesion consisting of immune cell infiltrates around and within the pancreatic islets of patients with recent-onset type 1 diabetes (T1D). The infiltration is typically mild, both in terms of the number of infiltrating cells and the number of islets affected. Here, we present an unusual histopathological case study of a 66-year-old female patient with long-standing T1D, insulitis, and islet-associated lymphoid tissue. Most islets in the head of the pancreas of this patient were insulin-deficient, whereas the islets in the tail appeared normal. Insulitis was present in 0.84% of the insulin-containing islets and three islets had large lymphocytic infiltrates resembling tertiary lymphoid structures (TLS). Of note, this is the first description of potential TLS in the endocrine pancreas of a patient with T1D. Their association with a marked residual beta cell mass is of interest and may hint at new insights into disease progression and regulation of autoimmunity.
Clinical outcomes following periodontal surgery and root surface decontamination by erythritol-based air polishing. A randomized, controlled, clinical pilot study
Authors: Cosgarea Raluca , Jepsen Søren , Fimmers Rolf , Bodea Aura , Eick Sigrun , Sculean Anton 
Published: August 2020

Abstract
Aim
To evaluate the outcomes following surgical periodontal treatment and root surface decontamination by means of air polishing using an erythritol powder or conventional mechanical root debridement.

Material and methods
Thirty systemically healthy patients (44.38 ± 8.2 years old, 11 smokers, 19 women) diagnosed with periodontitis stages III–IV were included. Each patient, with one single-rooted tooth, with one probing pocket depth (PD) ≥ 6 mm associated with horizontal bone loss, was treated by means of simplified papilla preservation flap (SPPF) and randomized to either test treatment (careful removal of the calculus with the tip of a blade, air polishing of the root surfaces with erythritol) or to the control group (scaling and root planing with hand curettes, ultrasonic instruments). PD, clinical attachment (CAL), bone sounding (BS), and radiographic bone level (BL) were evaluated at baseline and 12 months postsurgically.

Results
Twenty-seven patients completed the 12-month follow-up (test: n = 14, control: n = 13). In both groups, statistically significant improvements were obtained (p < 0.05, mean CAL gain/PD reduction: test, 2.50 ± 1.60 mm/3.00 ± 0.96 mm; control, 2.85 ± 1.21 mm/3.38 ± 1.12 mm). No statistically significant differences were observed between the groups for any of the investigated parameters (p < 0.05).

Conclusion
Within their limits, the present results indicate that the use of air polishing with an erythritol powder during periodontal surgery may represent a valuable minimally invasive adjunct following calculus removal by means of hand and ultrasonic instruments or a valuable alternative to these, for root surfaces without calculus.

Clinical relevance
The use of air polishing with an erythritol powder during periodontal surgery appears to represent a valuable minimally invasive adjunct following calculus removal by means of hand and ultrasonic instruments or a valuable alternative to these, for root surfaces without calculus.
Cation exchange behavior during the redox switching of poly (3,4-ethylenedioxythiophene) films
Authors: Gruia Violeta-Tincuţa , Ispas Adriana , Efimov Igor , Bund Andreas 
Published: August 2020

AbstractPoly (3,4-ethylenedioxythiophene), PEDOT, films were synthesized at room temperature by potentiodynamic and potentiostatic step deposition in aqueous solutions containing EDOT monomer and LiClO4. In some solutions, the effect of small amounts of sodium dodecylsulfate, SDS, on the polymerization rate of EDOT and on the stiffness of the obtained PEDOT film was studied. The obtained PEDOT films were transferred in aqueous solutions containing cations with different molar mass, such as H+, Li+, Na+, K+, and Cs+. The apparent molar masses of the exchanged species during potentiodynamic experiments were determined by in situ microgravimetry. These measurements underlined the importance of the electrolyte chosen for electropolymerization process. It is known that SDS anions can be trapped inside the polymer layer during electropolymerization, providing them with a cation exchange behavior. However, even if the PEDOT films were deposited from an electrolyte without SDS, they still acted as cation exchangers.
Familial writer’s cramp: a clinical clue for inherited coenzyme Q10 deficiency
Authors: Amprosi Matthias , Zech Michael , Steiger Ruth , Nachbauer Wolfgang , Eigentler Andreas , Gizewski Elke R. , Guger Michael , Indelicato Elisabetta , Boesch Sylvia 
Published: August 2020

AbstractThe spectrum of coenzyme Q10 (CoQ10) deficiency syndromes comprises a variety of disorders, including a form of autosomal recessive cerebellar ataxia (ARCA2) caused by mutations in the AarF domain–containing kinase 3 gene (ADCK3). Due to the potential response to CoQ10 supplementation, a timely diagnosis is crucial. Herein, we describe two siblings with a novel homozygous ADCK3 variant and an unusual presentation consisting of isolated writer’s cramp with adult-onset. Cerebellar ataxia developed later in the disease course and remained stable during the follow-up. This report highlights that ARCA2 should be considered in the differential diagnosis of familial writer’s cramp.
Families of toric chemical reaction networks
Authors: Adamer Michael F. , Helmer Martin 
Published: August 2020

AbstractWe study families of chemical reaction networks whose positive steady states are toric, and therefore can be parameterized by monomials. Families are constructed algorithmically from a core network; we show that if a family member is multistationary, then so are all subsequent networks in the family. Further, we address the questions of model selection and experimental design for families by investigating the algebraic dependencies of the chemical concentrations using matroids. Given a family with toric steady states and a constant number of conservation relations, we construct a matroid that encodes important information regarding the steady state behaviour of the entire family. Among other things, this gives necessary conditions for the distinguishability of families of reaction networks with respect to a data set of measured chemical concentrations. We illustrate our results using multi-site phosphorylation networks.
Modeling and Simulation of Microstructure Evolution for Additive Manufacturing of Metals: A Critical Review
Authors: Körner Carolin , Markl Matthias , Koepf Johannes A. 
Published: August 2020

Abstract
Beam-based additive manufacturing (AM) of metallic components is characterized by extreme process conditions. The component forms in a line-by-line and layer-by-layer process over many hours. Locally, the microstructure evolves by rapid and directional solidification. Modeling and simulation is important to generate a better understanding of the resultant microstructure. Based on this knowledge, the AM process strategy can be adapted to adjust specific microstructures and in this way different mechanical properties. In this review, we explain the basic concepts behind different modeling approaches applied to simulate AM microstructure evolution of metals. After a critical discussion on the range of applicability and the predictive power of each model, we finally identify future tasks.
Senecio scapioides (Compositae: Senecioneae: Senecioniinae): a new species from the Departamento de Boyacá, in Andean Colombia
Authors: Aguilar-Cano José , Hind D. J. Nicholas 
Published: August 2020

SummaryRoutine use of the virtual herbarium of the collections in COL (Instituto de Ciencias Naturales de la Universidad Nacional de Colombia) revealed the presence of an as yet undescribed species of Senecio amongst the material of Senecio adglacialis and S. leucanthemoides. Following subsequent herbarium studies and fieldwork, Senecio scapioides (Compositae: Senecioneae: Senecioniinae), from the Departamento de Boyacá, in Andean Colombia, was recognised and is described and illustrated; it is compared with S. adglacialis and S. leucanthemoides. Notes on its distribution and habitat, conservation status, phenology, and etymology are also provided, and the distribution of the three species mapped.
Evaluation of an alkali-polymer flooding technique for enhanced oil recovery in Trinidad and Tobago
Authors: Medica Kyle , Maharaj Rean , Alexander David , Soroush Mohammad 
Published: August 2020

AbstractTrinidad and Tobago (TT) is seeking to develop more economical methods of enhanced oil recovery to arrest the decline in crude oil production and to meet the current and future energy demand. The utilization of alkaline-polymer flooding to enhance oil recovery in TT requires key studies to be conducted to obtain critical information of the flooding system (soil type, additive type, pH, adsorption characteristics and rheological (flow) characteristics). Understanding the role of, interplay and optimizing of these variables will provide key input data for the required simulations to produce near realistic projections of the required EOR efficiencies. The parameters of various wells in TT were compared to the screening criteria for alkali-polymer flooding, and the EOR 4 well was found to be suitable and thus selected for evaluation. Laboratory adsorption studies showed that the 1000 ppm xanthan gum flooding solution containing 0.25% NaOH exhibited the lowest absorption capacity for the gravel packed sand and exhibited the lowest viscosity at all the tested shear rates. The lowest adsorption was 2.27 × 10−7 lbmole/ft3 which occurred with the 1000 ppm xanthan gum polymer containing 0.25% NaOH, and the evidence showed that the polymer was adsorbed on the other side of the faults, indicating that it has moved further and closer to the producing well. Implementation of an alkali polymer flooding resulted in an incremental increase in the recovery factors (~ 3%) compared to polymer flooding; however, a change in the oil recovery as a function of the alkaline concentration was not observed. The simulated economic analysis clearly shows that all the analysed EOR scenarios resulted in economically feasible outcomes of net present value (NPV), Internal Rate of Return (IRR) and payback period for oil price variations between $35 and $60 USD per barrel of oil. A comparison of the individual strategies shows that the alkali-polymer flood system utilizing 0.25% sodium hydroxide with 1000 ppm xanthan gum is the best option in terms of cumulative production, recovery factor, NPV, IRR and time to payback.