bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuroquinazolinones from Natural Furochromones (Visnagenone and Khellinone)
Authors: Abu-Hashem Ameen A. , Hussein Hoda A.R. , Aly Ahmed S. 
Published: April 2020

Background:Previous and recent scientific research has shown that triazolopyrimidine and furochromones have a wide range of pharmacological activities for the treatment of numerous diseases, including anticancer, antiviral, anti-depressant, anti-microbial, anti-inflammatory, and analgesic activities.Objective:Preparation of new drugs derived from a natural furochromones as (1-hydrazinyl or methylthio),-furopyrimidoquinazolinone, 1, 2, 4-triazolopyrimidofuroquinazolin-5-one, and quinazoline- pyrimidofuro- quinazoline-8, 10-dione and the study of their biological activity as antimicrobial agents.Method:A series of novel N’-furopyrimidoquinazoline-hydrazide; 1, 2, 4-triazolopyrimidofuroquinazolin- 5-one; furopyrimidoquinazolin-3-one and quinazoline-pyrimidofuroquinazoline-8, 10- dione derivatives were synthesized from substituted (methylthio)-furopyrimidoquinazolinone (3ab) and 1-hydrazinyl-furopyrimido- quinazolinone (4a-b) as the starting material.Results:All compounds were synthesized in good yields (71-95%) in a gradually efficient system under mild condition and some of the procedures were used such as microwave oven. The new compounds have been confirmed by means of different spectroscopic methods such as IR, 1D and 2D -NMR techniques and mass spectrum. The in vitro antimicrobial activities were evaluated for the prepared compounds using many types of bacteria (Gram-positive and Gram-negative) and fungi.Conclusion:1, 2, 4-triazolopyrimidofuroquinazolin-5-one derivatives (10a-f, 8a-b, 7a-b and 6a-d) showed the most efficient antimicrobial activities compared with the cefotaxime sodium and nystatin as standard drugs.
The Nexus Between Government Revenue and Economic Growth in Nigeria
Authors: Joseph Fineboy Ikechi , Omodero Cordelia Onyinyechi 
Published: April 2020

Abstract
The aim of the study is to examine the relationship between government revenues and the economic growth of Nigeria. The study employs exploratory and ex-post facto research designs while using secondary form of data spanning from 1981 to 2018 collected from the Federal Inland Revenue Services (FIRS), National Bureau of Statistics and CBN statistical bulletin. The relationship is tested by using Ordinary Least Squares (OLS) regression technique. The result reveals that federally received revenue and Value Added Tax (VAT) have a moderate positive relationship with the economic growth. The study provides evidence that there is a need for the government to formulate relevant revenue policies that will boost government income in order to have more favourable implication on the economy.
‘Vex the devil’: Scripture, God-talk and holiness at Villa Road
Authors: Smith Jennifer H. 
Published: April 2020

Abstract
This article gives a critical account of the engagement with Scripture among a group of women and men from the Villa Road Methodist Church, Handsworth, Birmingham, UK. It presents research done in community during 2004/05 for the unpublished thesis, ‘Mary in the Kitchen, Martha in the Pew: Patterns of Holiness in a Methodist Church’ (MPhil., Birmingham, 2006), updated to include critical engagement with contemporary scholarship in Black British theology, womanist and feminist theology, holiness teaching and hermeneutics, and congregational studies. Working from ethnographic research, the article considers three clusters of emphasis, or creative tensions, in the use of Scripture: gender and God, thanksgiving/resistance in response to evil, and displacement/home-coming. The article argues that these themes specially concern the negotiation of identity and relationship between self, God, Scripture and context.
Numerical Simulation of Heat Transfer Behavior of Dissimilar AA5052-AA6061 Plates in Fiction Stir Welding: An Experimental Validation
Authors: Vishwanath M. M. , Lakshamanaswamy N. , Ramesh G. K. 
Published: April 2020

Abstract
Fiction Stir welding (FSW) a unique type of metal joining process in solid state, where the heat generation takes place due to the friction action between the rotating tool and the work piece. It is generally used to join all series of Aluminum alloys with good strength and other metallic alloys finds difficult to weld through regular fusion welding techniques. The metal joining takes place in the solid state as the metal to be welded reaches about 80% to 90% of its melting temperature. The joining of metals in friction stir welding does not require any filler metals all classes of Aluminium alloys can be joined and in some desirable cases dissimilar metal compositions and Aluminiun metals composites can be joined satisfactorily. Joining of dissimilar metals has become a trend in the industries like aerospace, automotive chemical etc. as the helps in reducing the cost incurred by eliminating the costly materials. In the present study an experimental investigations are made to study the heat transfer behavior by determining the temperature distribution in AA5052-AA6061 plates during the Friction Stir welding. A three dimensional transient analysis is made by using ANSYS finite element analysis software. Thermocouples are placed at the suitable locations and the same point the temperature readings were taken from the simulation results. The experimental data is compared with the numerically simulated results. The numerical simulations results obtained are in better agreement with the experimental data obtained.
Implementation of Thoharoh in early childhood through Telling Story in Babadan Village
Authors: Rahmawati Lilis 
Published: April 2020

Thoharoh became the basis of a practice of worship, as it became the condition of worship. So it is necessary to be taught since early childhood is good and correct. Since early childhood is the Golden Age. This research aims to discuss the implementation of education in Thoharoh in early childhood in Babadan village. Using a descriptive method is a clear picture of delivering, presenting, and concluding data. Population retrieval and samples from the research object as a tool to obtain data from an issue that is also required by the authors. As for digging data, the methods used are documentation methods, interviews, polls and to know the type of data using qualitative data. His study was done very impressively through various fun games, demonstrations and Thoharoh festivals. The results showed that Thoharoh could be implemented early on through a pleasant method. With the hope that parents participate in this religious education so that the child can practice it optimally.
Addressing the Unmet Needs of Measuring Vascular Ageing in Clinical Practice—European COoperation in Science and Technology Action VascAgeNet
Authors: Climie Rachel Emma , Mayer Christopher Clemens , Bruno Rosa Maria , Hametner Bernhard 
Published: April 2020

AbstractCardiovascular Disease (CVD) is the leading cause of morbidity and mortality worldwide, regardless of gender, ethnicity or income. Evidence that vascular age, as opposed to chronological age, is better related to the prognosis of CVD is convincing. Despite recent technological advances for the measurement of vascular ageing, unmet needs remain which currently limit the assessment of vascular ageing in routine clinical practice. These unmet needs include: (1) lack of easy-to-use, affordable techniques/devices, (2) insufficient validation in clinical settings, (3) fragmentation of expertise in few research laboratories globally, and (4) lack of investigator/research driven intervention studies and head-to-head comparisons between different measurement techniques. This paper summarises how a recently awarded European COoperation in Science and Technology (COST) Action on Vascular Ageing (VascAgeNet) will address these unmet needs. The broad aim of the COST Action VascAgeNet is to establish a network which will work to refine, harmonize and promote the use of vascular ageing biomarkers, in order to improve clinical practice and to reduce the burden of CVD globally.
Effect of Urbanization on Land use Land Cover in Gombe Metropolis
Authors: Mbaya L.A. , Abu G. O. , Caiaphas Makadi Yila , Umar D.M. 
Published: April 2020

This study examined the integration of Remote Sensing and Geographic Information System (RS/GIS) for analyzing land use and land cover dynamics in Gombe Metropolitan, the Gombe State capital for the period 1976 to 2016. Land sat (TM) images of 1976, 1996and 2016 were used. The study employed supervised digital image classification method using Erdas Imagine 9.2 and Arc GIS 10.5 software and classified the land use into undisturbed vegetation, sparse vegetation, Settlements, Farmlands, Rock outcrops, Bare surfaces. The images were analyzed via georeferencing, image enhancement, image resampling and classification. The results obtained show an increasing settlements (from 0.36% - 4.01%) and farmlands (from 24.8% - 51.2%), over a decreasing of other LULC classes (bare surfaces, undisturbed and sparse vegetation, and rocky outcrops) for the time period of 1976 to 2016. These results could help city planners and policy makers to attain and sustain future urban development. It is therefore recommended that encouragement should be given to people to build towards the outskirts, like New mile 3 and Tumfure, etc through the provision of incentives and forces of attraction that is available at the city center in these areas to avoid the problem of overcrowdings.
Ease and Level of use of Smartphone for Learning Amongst Pre-Service Teachers Colleges of Education in North-West, Nigeria
Authors: Abubakar Ismaila Abdullahi , Kadage Tukur Abdullahi , Amoson Gambari Isiaka 
Published: April 2020

This study “ease and level of use of smartphone for learning amongst pre-service teachers colleges of education in North-West, Nigeria” was guided by two objectives, two research questions. The researchers used descriptive survey research design in the study. The researchers used mixed method (quantitative and qualitative) for data collection. The population of the study was 113,030. Random sampling technique was employed to select the sample. The total population of the sample is 32,300. The entire sample that was chosen is 371 for quantitative which is in line with Raosoft sample size and 6 for qualitative. The instruments used for data collection were adopted questionnaire prediction of user acceptance and adoption of smartphone for learning with technology acceptance model questionnaire (PUAASLTAMQ) by Sek, et al, (2010) and data-blank. The frequency and percentage were employed to analyze the respondents’ demographic information. To answer research question one (1), descriptive statistics (frequencies and percentages) were used. To answer research question two t-test was used. The summary of the major findings indicated that smartphone is very easy to use for learning by the pre-service teachers in Colleges of Education in North-West, Nigeria and male pre-service teachers in Colleges of Education in North-West, Nigeria use smartphone for learning more than their female counterpart. The research shows that smartphone may be accepted as instructional tool in future, because the mode of smartphone operation is not difficult.
Pemisahan Campuran Asam Lemak Dengan Metode Kromatografi Kolom Menggunakan Fasa Diam Berbahan Dasar Abu Sekam Padi
Authors: Widiastuti Endang 
Published: April 2020

Indonesia sebagai negara agraris mempunyai banyak jenis tumbuhan penghasil minyak nabati yang mengandung asam lemak jenuh dan tidak jenuh. Asam lemak tersebut dimanfaatkan oleh industri makanan dan obat-obatan. Asam-asam lemak yang masih berupa campuran perlu dipisahkan, salah satunya dengan metoda kromatografi ion perak. Prinsip dari metode ini adalah berdasarkan perbedaan afinitas antara asam lemak dengan fasa diam dan fasa gerak. Salah satu faktor yang menentukan tingkat keberhasilan proses pemisahan pada kromatografi adalah fasa diam. Pada penelitian ini, fasa diam diperoleh dengan memanfaatkan silika yang terkandung dalam abu sekam padi. Silika yang diperoleh berbentuk sol yang kemudian dimodifikasi dengan AgNO3 menggunakan senyawa pendukung yang divariasikan jenisnya yaitu amino propil trimetoksisilan (APTS) dan kitosan. Kedua jenis silika yang dimodifikasi kemudian dianalisis kadar ion Ag yang terikat secara titrasi potensiometri, Selanjutnya silika tersebut digunakan sebagai fasa diam pada kolom kromatografi padat-cair, untuk memisahkan campuran asam oleat, asam palmitat dan asam stearat yang telah dimetilasi. Eluen yang digunakan pada pemisahan adalah campuran kloroform- metanol atau benzene-metanol yang komposisinya divariasikan antara 100:0 hingga 90:10. Hasil pemisahan dari kolom tersebut dianalisis menggunakan kromatografi gas (GC). Dari penelitian ini, ion Ag yang terikat pada silika-kitosan adalah 87% sedangkan silika-APTS adalah 89% karena perbedaannya tidak signifikan maka sebagai fasa diam pada kolom kromatografi digunakan silika kitosan. Berdasarkan hasil analisis secara SEM dan EDS, silika tersebut mengandung SiO2 69% dan Ag2O 18%. Hasil pemisahan dari kolom kromatografi menunjukan bahwa campuran metil oleat dan metil palmitat dapat dielusi dengan pelarut kloroform – methanol, sedangkan campuran metil palmitat dan metil stearat dielusi dengan pelarut benzena-metanol. Kedua jenis eleun tersebut mempunyai perbandingan komposisi yang sama yaitu 97:3.
Evaluasi Deteksi Berbasis PCR untuk Bakteri Bifidobacterium longum dalam Sampel Feses Bayi dari Kota Manado
Authors: Kolondam Beivy Jonathan 
Published: April 2020

Bifidobakteria merupakan mikroflora yang umum hidup dalam usus manusia sejak bayi. Peran Bifidobacterium longum yang positif sebagai salah satu bakteri yang menunjang kesehatan inangnya membuat bakteri ini menjadi objek studi yang menarik. Salah satu instrumen dalam penelitian adalah adalah metode deteksi bakteri B. longum yang berbasis PCR (Polymerase Chain Reaction) gen 16S rRNA. Dengan mempertimbangkan bahwa perancangan primer untuk deteksi ini sudah lebih dari 20 tahun, penelitian ini bertujuan mengevaluasi hasil deteksi melalui PCR terhadap B. longum dalam feses bayi. Akurasi hasil dilihat melalui sekuensing terhadap hasil PCR sampel yang terdeteksi positif. Dua sampel feses bayi di Manado yang diperiksa menunjukkan hasil positif dan produk PCR tersebut dilakukan sekuensing. Panjang DNA yang nyata dari hasil deteksi ini yaitu 829 bp dan bukan 831 bp. Sekuens DNA kedua sampel ini identik satu sama lain. Hasil BLAST (Basic Local Alignment Search Tool) mengonfirmasi kesamaan 100% (identik) dari kedua specimen dari Kota Manado dengan sekuens gen 16S rRNA specimen bakteri B. longum yang telah ada dalam GenBank.Kata-kata kunci: Bifidobacterium longum, Polymerase Chain Reaction, deteksi, feses, bayi. Evaluation of PCR-Based Detection for Bifidobacterium longum in Infant Fecal Samples from Manado City ABSTRACTBifidobacteria are common members of the gut microflora of humans since infant. The Bifidobacterium longum has positive roles and one of supportive bacteria to the host, which made interesting as a study object. One instrument in studying this bacterial species is the detection method based on PCR of 16S rRNA gene. In consideration of the design of primers for this detection method is already more than 20 years, this research aimed to evaluate the PCR-based detection of B. longum in infant feces. The accuracy of the method was evaluated from sequencing of DNA fragment from positive results. Two fecal samples in Manado City shown positive result were sent for sequencing. The actual length of DNA amplified by PCR was 829 bp, not 831 bp. The DNA sequence of both samples were identical to each other. The BLAST (Basic Local Alignment Search Tool) result confirmed the similarity of both samples from Manado with 16S rRNA gene sequence of B. longum specimens in GenBank.Keywords: Bifidobacterium longum, Polymerase Chain Reaction, detection, feces, infant.
STUDY THE ANTIBACTERIAL ACTIVITY OF AQUEOUS EXTRACTION OF ONION (Allium cepaL) AGAINST Staphylococcus aureus ISOLATED FROM OTITIS MEDIA.
Authors: &et al. Ibrahim 
Published: April 2020

This study was aimed to determine the antibacterial activity of onion (Allium cepaL.) aqueous extract against S. aureus bacteria isolated from patients with otitis media. Twenty swabs samples were taken from patients with otitis infection; these samples were cultured on different agar media .Results revealed that half of these isolates were related to S. aureus and the five of these isolates were subject to sensitivity test against several antibiotic groups. Most of isolates 100% were resistance to amoxicillin, chloramphenicol, cefoxitin and pencillin, and 60 % of were showed resistance to cefotaxtime and tetracycline, where as 20 % were resistance to Ciprofloxacin. Depending on the results of antibiotic sensitivity, the two isolates(S2,S5) were chosen for determining the minimum inhibitory concentration (MIC) test, S2 isolate showed high-level of resistance at (16 and 128 µg/ml) to chloraemphenicol, amoxicillin, ampicillin and Cefotaxime respectively, while S5 at concentration (32, 64 and 128 µg\ml) were resistance to amoxicillin, ampicillin, chloraemphenicol and cefotaxtime. The MIC of onion extract against S. aureus was determined at two incubation periods The results were indicated that after 24 hrs, MIC of extract at 64 µg/ml was affected in inhibit the growth of S2 isolate, While 32 µg/ml was inhibited the growth of S5 isolate.However, after 72 hrs, It was found that the MIC at 32, 64 and 128 µg/ml were more effective in inhibited the growth of S2 and S5 isolates.
PENGARUH LIKUIDITAS DAN PROFITABILITAS TERHADAP DIVIDEND PAYOUT RATIO
Authors: Lismana Heliani 
Published: April 2020

Abstrak - Dividen merupakan salah satu tujuan investor untuk menanamkan modalnya. Untuk adanya pengembalian dividen tersebut dapat dilihat dari seberapa baik likuiditas dan profitabilitas yang dicapai oleh perusahaan. Semakin baik likuiditas dan profitabilitas perusahaan maka akan semakin memungkinkan perusahaan membayarkan dividen kepada para pemegang saham. Penelitian ini bertujuan untuk menguji bagaimana pengaruh likuiditas dan profitabilitas terhadap dividend payout ratio (DPR). Variabel likuiditas diukur dengan menggunakan Loan to Deposit Ratio (LDR), Profitabilitas diukur dengan menggunakan Return on Asset (ROA), dan pembayaran dividen menggunakan Dividend Payout Ratio (DPR). Dalam penelitian ini populasi yang digunakan sebanyak 55 perusahaan sektor perbankan yang terdaftar di Bursa Efek Indonesia periode 2013-2017. Pemilihan sampel penelitian menggunakan metode purposive sampling sehingga didapatkan 8 perusahaan sektor perbankan yang memenuhi kriteria. Pengujian hipotesis menggunakan analisis regresi linier berganda untuk mengetahui pengaruh antar variabel dengan menggunakan bantuan SPSS. Dari hasil pengujian statistik tersebut menunjukan bahwa menunjukkan bahwa likuiditas berpengaruh terhadap dividend payout ratio. Sedangkan profitabilitas tidak berpengaruh terhadap dividend payout ratio.

Abstract - Dividends are one of the objectives of investors to invest their capital. For representatives of dividends that can be seen from the liquidity and profitability obtained by the company. The better the company's liquidity and profitability, the more it will be possible for companies to pay dividends to shareholders. This study discusses how to increase liquidity and profitability on dividend payout ratio (DPR). Liquidity variables ismeasured using a Loan to Deposit Ratio (LDR), profitability is measure using Return on Assets (ROA), and dividend payments using Dividend Payout Ratio (DPR). In this study the population used was 55 banking companies listed on the Indonesia Stock Exchange in the period 2013-2017. The research sample selection uses a purposive sampling method obtained by 8 banking sector companies that meet the criteria. Hypothesis testing uses multiple linear regression to determine the influence between variables by using SPSS. Statistical test result show that based on regression testing, liquidity has effect to dividend payments. While profitability does not affect dividend payout ratios.
IRAK-M Regulates Monocyte Trafficking to the Lungs in Response to Bleomycin Challenge
Authors: Reader Brenda F. , Sethuraman Shruthi , Hay Bryan R. , Thomas Becket Rose Viguna , Karpurapu Manjula , Chung Sangwoon , Lee Yong Gyu , Christman John W. , Ballinger Megan N. 
Published: April 2020

Abstract
Idiopathic pulmonary fibrosis is a deadly disease characterized by excessive extracellular matrix deposition in the lungs, resulting in decreased pulmonary function. Although epithelial cells and fibroblasts have long been the focus of idiopathic pulmonary fibrosis research, the role of various subpopulations of macrophages in promoting a fibrotic response is an emerging target. Healthy lungs are composed of two macrophage populations, tissue-resident alveolar macrophages and interstitial macrophages, which help to maintain homeostasis. After injury, tissue-resident alveolar macrophages are depleted, and monocytes from the bone marrow (BM) traffic to the lungs along a CCL2/CCR2 axis and differentiate into monocyte-derived alveolar macrophages (Mo-AMs), which is a cell population implicated in murine models of pulmonary fibrosis. In this study, we sought to determine how IL-1R–associated kinase-M (IRAK-M), a negative regulator of TLR signaling, modulates monocyte trafficking into the lungs in response to bleomycin. Our data indicate that after bleomycin challenge, mice lacking IRAK-M have decreased monocyte trafficking and reduced Mo-AMs in their lungs. Although IRAK-M expression did not regulate differences in chemokines, cytokines, or adhesion molecules associated with monocyte recruitment, IRAK-M was necessary for CCR2 upregulation following bleomycin challenge. This finding prompted us to develop a competitive BM chimera model, which demonstrated that expression of BM-derived IRAK-M was necessary for monocyte trafficking into the lung and for subsequent enhanced collagen deposition. These data indicate that IRAK-M regulates monocyte trafficking by increasing the expression of CCR2, resulting in enhanced monocyte translocation into the lung, Mo-AM differentiation, and development of pulmonary fibrosis.