bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the mechanical properties of high-strength cement paste at elevated temperatures using metakaolin
Authors: Abdelmelek Nabil , Lubloy Eva 
Published: July 2020

AbstractThis paper presents a wide experimental study, in which it evaluates the performance of high-strength paste exposed to elevated temperatures up to 900 °C. Several factors have been investigated at the age of 90 days, i.e. metakaolin (MK) dosages, water to binder ratio (w/b) as well as elevated temperatures. Results proved that MK improves the relative residual compressive strength and relative residual bending strength showing a gain up to 52% and of 71% at 500 °C, respectively, compared to the pure cement paste in case of 0.3 w/b. The maximum use of MK is not more than 12%, and the optimum dosages were 9, 12, and 12% of MK replacements for 0.3, 0.35, and 0.4 w/b, respectively. The optimum dosage could change with changing w/b ratio and this up to the density of the microstructure which is controlled by the amount of w/b ratio and the packing effect of MK amount. In addition to the mechanical properties, the adoption of MK decreases the cracking of the specimens at elevated temperatures. SEM investigations show the positive physical morphology contribution of MK, specific surface area as well as its chemical composition for decreasing the Ca(OH)2effect. Different phases that formed during temperatures elevation are illustrated by TG analysis. Results showed the reason behind using MK on the cracking enhancement and mechanical properties improvement after high temperatures exposure. Meanwhile, the obtained optimum MK dosages at ambient temperature are not similar to that obtained at elevated temperatures.
A history of post-communist remembrance: from memory politics to the emergence of a field of anticommunism
Authors: Dujisin Zoltan 
Published: July 2020

AbstractThis article invites the view that the Europeanization of an antitotalitarian “collective memory” of communism reveals the emergence of a field of anticommunism. This transnational field is inextricably tied to the proliferation of state-sponsored and anticommunist memory institutes across Central and Eastern Europe (CEE), but cannot be treated as epiphenomenal to their propagation. The diffusion of bodies tasked with establishing the “true” history of communism reflects, first and foremost, a shift in the region’s approach to its past, one driven by the right’s frustration over an allegedly pervasive influence of former communist cliques. Memory institutes spread as the CEE right progressively perceives their emphasis on research and public education as a safer alternative to botched lustration processes. However, the field of anticommunism extends beyond diffusion by seeking to leverage the European Union institutional apparatus to generate previously unavailable forms of symbolic capital for anticommunist narratives. This results in an entirely different challenge, which requires reconciling of disparate ideological and national interests. In this article, I illustrate some of these nationally diverse, but internationally converging, trajectories of communist extrication from the vantage point of its main exponents: theanticommunist memory entrepreneurs, who are invariably found at the helm of memory institutes.Inhabiting the space around the political, historiographic, and Eurocratic fields, anticommunist entrepreneurs weave a complex web of alliances that ultimately help produce an autonomous field of anticommunism.
High expression levels of pyrimidine metabolic rate–limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets
Authors: Wang Haiwei , Wang Xinrui , Xu Liangpu , Zhang Ji , Cao Hua 
Published: July 2020

AbstractReprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of pyrimidine metabolism signaling pathway in lung adenocarcinoma (LUAD) is unclear. Using the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets, we found that the pyrimidine metabolism signaling pathway was significantly enriched in LUAD. Compared with normal lung tissues, the pyrimidine metabolic rate–limiting enzymes were highly expressed in lung tumor tissues. The high expression levels of pyrimidine metabolic–rate limiting enzymes were associated with unfavorable prognosis. However, purinergic receptors P2RX1, P2RX7, P2RY12, P2RY13, and P2RY14 were relatively downregulated in lung cancer tissues and were associated with favorable prognosis. Moreover, we found that hypo-DNA methylation, DNA amplification, and TP53 mutation were contributing to the high expression levels of pyrimidine metabolic rate–limiting enzymes in lung cancer cells. Furthermore, combined pyrimidine metabolic rate–limiting enzymes had significant prognostic effects in LUAD. Comprehensively, the pyrimidine metabolic rate–limiting enzymes were highly expressed in bladder cancer, breast cancer, colon cancer, liver cancer, and stomach cancer. And the high expression levels of pyrimidine metabolic rate–limiting enzymes were associated with unfavorable prognosis in liver cancer. Overall, our results suggested the mRNA levels of pyrimidine metabolic rate–limiting enzymes CAD, DTYMK, RRM1, RRM2, TK1, TYMS, UCK2, NR5C2, and TK2 were predictive of lung cancer as well as other cancers.
Regular endurance exercise of overloaded muscle of young and old male mice does not attenuate hypertrophy and improves fatigue resistance
Authors: Hendrickse Paul William , Krusnauskas Raulas , Hodson-Tole Emma , Venckunas Tomas , Degens Hans 
Published: July 2020

AbstractIt has been observed that there is an inverse relationship between fiber size and oxidative capacity due to oxygen, ADP, and ATP diffusion limitations. We aimed to see if regular endurance exercise alongside a hypertrophic stimulus would lead to compromised adaptations to both, particularly in older animals. Here we investigated the effects of combining overload with regular endurance exercise in young (12 months) and old (26 months) male mice. The plantaris muscles of these mice were overloaded through denervation of synergists to induce hypertrophy and the mice ran on a treadmill for 30 min per day for 6 weeks. The hypertrophic response to overload was not blunted by endurance exercise, and the increase in fatigue resistance with endurance exercise was not reduced by overload. Old mice demonstrated less hypertrophy than young mice, which was associated with impaired angiogenesis and a reduction in specific tension. The data of this study suggest that combining endurance exercise and overload induces the benefits of both types of exercise without compromising adaptations to either. Additionally, the attenuated hypertrophic response to overload in old animals may be due to a diminished capacity for capillary growth.
Using Social Life Cycle Assessment to analyze the contribution of products to the Sustainable Development Goals: a case study in the textile sector
Authors: Herrera Almanza Ana María , Corona Blanca 
Published: July 2020

Abstract
Purpose
Evaluation and monitoring systems are perceived as an effective tool to understand and improve the contribution of business activities to the accomplishment of the Sustainable Development Goals (SDGs). However, there is currently a lack of guidance and support on assessing the influence that the life cycle of products and services has on the SDGs. This article presents a case study where Social Life Cycle Assessment (S-LCA) is applied to understand the social performance of a textile product and its potential contribution to the SDGs.

Methods
In this study, the link between the S-LCA methodology and the SDG framework was made at the indicator level, through a new classification of S-LCA indicators. This classification was aimed at indicating the positive or negative contribution of products or services into the SDGs. The method was tested with the case study of a man’s shirt whose supply chain takes place across five countries, from the cotton farming in China to the retailing in The Netherlands. The social performance of the shirt’s life cycle was analyzed through a social hotspot assessment (using PSILCA database) and a site-specific assessment following the UNEP/SETAC S-LCA guidelines. Primary data was collected for 6 different suppliers regarding 51 social indicators and four stakeholder categories (workers, local communities, value chain actors, and society).

Results and discussion
The social hotspot assessment indicated high social risks on indicators related to the following SDGs: health and well-being, affordable and clean energy, decent work, and responsible production and consumption. These risks were mainly located in Bangladesh (shirt manufacturing) and Malaysia (fabric manufacturing). The site-specific assessment indicated different results than the social risk assessment, showing worse social performance in the spinning stage (located in China). Negative scores were obtained for every supplier in at least four indicators, including working hours, safe and healthy living conditions, and access to immaterial resources.

Conclusions
The results indicated negative social performance of the supply chain in most of the SDGs and identified points of improvement for the final retailer. The linkage of the S-LCA framework with the SDGs presented methodological challenges, mainly related to the different scope of the SDG indicators and the S-LCA indicators.
CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature
Authors: Siriwardena B. S. M. S. , Speight Paul M. , Franklin Christopher D. , Abdelkarim Rasha , Khurram Syed Ali , Hunter Keith D. 
Published: July 2020

AbstractThe first detailed description of calcifying epithelial odontogenic tumor (CEOT) are ascribed to Jens Pindborg, but this tumor was described some years previously. Subsequently, CEOT was included in the 1971 WHO classification of odontogenic tumors and a since then number of variants have been described, which have added confusion to the diagnostic criteria. We aimed to survey the literature on the variants of CEOT, in parallel with a review of our single institution experience of CEOTs. Cases identified were collated, including available clinical, radiological and histological information and then reviewed, taking into account changes in the understanding and classifications of odontogenic tumors since initial diagnosis. We identified 26 cases from 1975 to 2017 for which histological material was available. Of these, only 13 (50%) showed the “classic” histological appearance, whilst two cases were identified as recognized variants. In 11 cases, other diagnoses or a differential diagnosis were preferred, with no agreed diagnosis in four of these. The proliferation fraction (Ki67) in the 10 cases tested was 2.1% ± 0.18. These findings illustrate the diagnostic challenges in this group of tumors and highlight the gaps in knowledge. Techniques, such as EWSR1 gene cytogenetic analysis, may be helpful in cases with clear cells. However, in other areas of controversy, including the non-calcifying and Langerhans cell rich variants, further investigation, perhaps utilizing sequencing technologies may be needed to refine the classification. Owing to the relative rarity of these lesions it would be beneficial if future work could be pursued as an international collaboration.
Intellectually Humble, but Prejudiced People. A Paradox of Intellectual Virtue
Authors: Colombo Matteo , Strangmann Kevin , Houkes Lieke , Kostadinova Zhasmina , Brandt Mark J. 
Published: July 2020

AbstractIntellectual humility has attracted attention in both philosophy and psychology. Philosophers have clarified the nature of intellectual humility as an epistemic virtue; and psychologists have developed scales for measuring people’s intellectual humility. Much less attention has been paid to the potential effects of intellectual humility on people’s negative attitudes and to its relationship with prejudice-based epistemic vices. Here we fill these gaps by focusing on the relationship between intellectual humility and prejudice. To clarify this relationship, we conducted four empirical studies. The results of these studies show three things. First, people are systematically prejudiced towards members of groups perceived as dissimilar. Second, intellectual humility weakens the association between perceived dissimilarity and prejudice. Third, more intellectual humility is associated withmoreprejudice overall. We show that this apparently paradoxical pattern of results is consistent with the idea that it is both psychologically and rationally plausible that one person is at the same time intellectually humble, epistemically virtuous and strongly prejudiced.
Interpretative Pros Hen Pluralism: from Computer-Mediated Colonization to a Pluralistic Intercultural Digital Ethics
Authors: Ess Charles Melvin 
Published: July 2020

AbstractIntercultural Digital Ethics (IDE) faces the central challenge of how to develop aglobalIDE that can endorse and defend some set of (quasi-) universal ethical norms, principles, frameworks, etc.alongsidesustaining local, culturally variable identities, traditions, practices, norms, and so on. I explicate interpretivepros hen(focal or “towards one”) ethical pluralism (EP(ph)) emerging in the late 1990s and into the twenty-first century in response to this general problem and its correlates, including conflicts generated by “computer-mediated colonization” that imposed homogenous values, communication styles, and so on upon “target” peoples and cultures via ICTs as embedding these values in their verydesign. I contrast different kinds of ethical pluralisms as structural apparatus for understanding whatdifferencesmay mean and allow for, as these emerged in the 1990s forwards with EP(ph). As interwoven withphronēsis, a form of reflective judgment and virtue, EP(ph) more radically preserves irreducible differences and so fosters positive engagements across deep cultural differences. I show how EP(ph) emerged in the context of empirical research on “Cultural Attitudes towards Technology and Communication” (CATaC) beginning in 1998, and then in specific applications within Internet Research Ethics (IRE) beginning in 2000. I summarize its main characteristics and trace how it has further been taken up in ICE, IRE, Intercultural Information Ethics, and virtue ethics more broadly. I respond to important criticisms and objections, arguing that EP(ph) thus stands as an important component for a contemporary IDE that seeks an ethicalcosmopolitanismin place of computer-mediated colonization.
Network-inference-based prediction of the COVID-19 epidemic outbreak in the Chinese province Hubei
Authors: Prasse Bastian , Achterberg Massimo A. , Ma Long , Van Mieghem Piet 
Published: July 2020

AbstractAt the moment of writing, the future evolution of the COVID-19 epidemic is unclear. Predictions of the further course of the epidemic are decisive to deploy targeted disease control measures. We consider a network-based model to describe the COVID-19 epidemic in the Hubei province. The network is composed of the cities in Hubei and their interactions (e.g., traffic flow). However, the precise interactions between cities is unknown and must be inferred from observing the epidemic. We propose the Network-Inference-Based Prediction Algorithm (NIPA) to forecast the future prevalence of the COVID-19 epidemic in every city. Our results indicate that NIPA is beneficial for an accurate forecast of the epidemic outbreak.
Balanced Semi-Latin Rectangles: Properties, Existence and Constructions for Block Size Two
Authors: Uto N. P. , Bailey R. A. 
Published: July 2020

AbstractThere exists a set of designs which form a subclass of semi-Latin rectangles. These designs, besides being semi-Latin rectangles, exhibit an additional property of balance, where no two distinct pairs of symbols (treatments) differ in their concurrences, that is, each pair of distinct treatments concurs a constant number of times in the design. Such a design exists for a limited set of parameter combinations. We designate it a balanced semi-Latin rectangle and give some properties and necessary conditions for its existence. Furthermore, algorithms for constructing the design for experimental situations where there are two treatments in each row–column intersection (block) are also given.
End-stage renal disease reduces the expression of drug-metabolizing cytochrome P450s
Authors: Déri Máté Tamás , Kiss Ádám Ferenc , Tóth Katalin , Paulik József , Sárváry Enikő , Kóbori László , Monostory Katalin 
Published: July 2020

Abstract
Background
End-stage renal disease is an irreversible status of kidney dysfunction that reduces both renal and non-renal drug clearance. Accumulation of uremic toxins seems to modify the activities of drug-metabolizing cytochrome P450 (CYP) enzymes. The aim of the present work was to refine gene expression analysis for efficient and accurate quantification of CYP mRNAs in patients’ leukocytes.

Methods
We compared six liquid–liquid extraction reagents for RNA isolation and five reverse transcriptase kits for RNA-to-cDNA conversion, and developed quantitative polymerase chain reaction methods for duplex measurements of CYP target genes and the reference gene. The expression of CYP1A2, CYP2C9, CYP2C19 and CYP3A4 in patients with end-stage kidney disease (N = 105) and in organ donors with healthy kidney function (N = 110) was compared.

Results
Regarding the RNA yield and purity, TRIzol, Trizolate and TRI reagents were equal; however, TRI reagent was the most advantageous in terms of financial cost. Reverse transcription using Maxima First Strand cDNA Synthesis kit appeared to be the most efficient with the widest range for quantification of the target transcript. The refined method with the detection of various CYPs and the reference gene in duplex PCR efficiently quantified even the low-level CYP expression. In leukocytes of patients with end-stage renal disease, all four CYPs were expressed at significantly lower level than in organ donors with normal kidney function (p < 0.0001).

Conclusions
Reduced CYP expression was a direct evidence of transcriptional down-regulation of CYP genes in patients with impaired kidney function.
Predicting Regulatory Product Approvals Using a Proposed Quantitative Version of FDA’s Benefit–Risk Framework to Calculate Net-Benefit Score and Benefit–Risk Ratio
Authors: Sun Stephen , Heske Suzanne , Mercadel Melanie , Wimmer Jean 
Published: July 2020

Abstract
Background
Approval of regulated medical products in the USA is based upon a rigorous review of the benefits and risks as performed by the US Food and Drug Administration (FDA) staff of scientists and is summarized in a descriptive and qualitative format called the FDA’s Benefit–Risk Framework (BRF). This present method highlights the key factors in regulatory decision-making, but does not clearly define the reason for its final approval.

Method
This study proposes a quantitative version of FDA’s BRF to calculate a Net-Benefit Score and a Benefit–Risk Ratio as a method to define a single-value summary of the tradeoffs between benefits and risks and allow comparisons among other products. In this retrospective review of five years of new molecular entities and new biologic (N = 185 products) regulatory decision-making, this proposed scoring system codifies and quantitates the information about a product’s benefits, risks, and risk management information in a format that may predict why regulated medical products are approved in the USA.

Results
Simple calculation of codified benefits, risks, and risk mitigations with numerical limits is proposed to provide a repeatable process and transparency for documenting the net-benefit of regulatory product approval.

Conclusion
Use of a strict process of collecting, codifying, and analyzing public information to determine a Net-Benefit score and a Benefit–Risk Ratio is possible to anticipate regulatory product approval.
Monitoring evolution of melt ponds on first-year and multiyear sea ice in the Canadian Arctic Archipelago with optical satellite data
Authors: Li Qing , Zhou Chunxia , Zheng Lei , Liu Tingting , Yang Xiaotong 
Published: July 2020

AbstractThe evolution of melt ponds on Arctic sea ice in summer is one of the main factors that affect sea-ice albedo and hence the polar climate system. Due to the different spectral properties of open water, melt pond and sea ice, the melt pond fraction (MPF) can be retrieved using a fully constrained least-squares algorithm, which shows a high accuracy with root mean square error ~0.06 based on the validation experiment using WorldView-2 image. In this study, the evolution of ponds on first-year and multiyear ice in the Canadian Arctic Archipelago was compared based on Sentinel-2 and Landsat 8 images. The relationships of pond coverage with air temperature and albedo were analysed. The results show that the pond coverage on first-year ice changed dramatically with seasonal maximum of 54%, whereas that on multiyear ice changed relatively flat with only 30% during the entire melting period. During the stage of pond formation, the ponds expanded rapidly when the temperature increased to over 0°C for three consecutive days. Sea-ice albedo shows a significantly negative correlation (R= −1) with the MPF in melt season and increases gradually with the refreezing of ponds and sea ice.
Hawkish Partisans: How Political Parties Shape Nationalist Conflicts in China and Japan
Authors: Incerti Trevor , Mattingly Daniel , Rosenbluth Frances , Tanaka Seiki , Yue Jiahua 
Published: July 2020

AbstractIt is well known that regime types affect international conflicts. This article explores political parties as a mechanism through which they do so. Political parties operate in fundamentally different ways in democracies vs. non-democracies, which has consequences for foreign policy. Core supporters of a party in a democracy, if they are hawkish, may be more successful at demanding hawkish behavior from their party representatives than would be their counterparts in an autocracy. The study draws on evidence from paired experiments in democratic Japan and non-democratic China to show that supporters of the ruling party in Japan punish their leaders for discouraging nationalist protests, while ruling party insiders in China are less likely to do so. Under some circumstances, then, non-democratic regimes may be better able to rein in peace-threatening displays of nationalism.