bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetically controlled growing rods in the treatment of early onset scoliosis
Authors: Abdelaal Ahmed , Munigangaiah Sudarshan , Trivedi Jayesh , Davidson Neil 
Published: November 2020

Aims Magnetically controlled growing rods (MCGR) have been gaining popularity in the management of early-onset scoliosis (EOS) over the past decade. We present our experience with the first 44 MCGR consecutive cases treated at our institution. Methods This is a retrospective review of consecutive cases of MCGR performed in our institution between 2012 and 2018. This cohort consisted of 44 children (25 females and 19 males), with a mean age of 7.9 years (3.7 to 13.6). There were 41 primary cases and three revisions from other rod systems. The majority (38 children) had dual rods. The group represents a mixed aetiology including idiopathic (20), neuromuscular (13), syndromic (9), and congenital (2). The mean follow-up was 4.1 years, with a minimum of two years. Nine children graduated to definitive fusion. We evaluated radiological parameters of deformity correction (Cobb angle), and spinal growth (T1-T12 and T1-S1 heights), as well as complications during the course of treatment. Results The mean Cobb angles pre-operatively, postoperatively, and at last follow-up were 70° (53 to 103), 35° (15 to 71) and 39° (15 to 65) respectively (p < 0.001). Further, there was a mean of 14° (-6 to 27) of additional Cobb angle correction upon graduation from MCGR to definitive fusion. Both T1-T12 and T1-S1 showed significant increase in heights of 27 mm and 45 mm respectively at last follow-up (p < 0.001). Ten children (23%) developed 18 complications requiring 21 unplanned operations. Independent risk factors for developing a complication were single rod constructs and previous revision surgery. Conclusion MCGR has the benefit of avoiding multiple surgeries, and is an effective tool in treatment of early-onset scoliosis. It also maintains the flexibility of the spine, allowing further correction at the time of definitive fusion. Cite this article: Bone Joint Open 2020;1-7:405–414.
PINE: Photonic Integrated Networked Energy efficient datacenters (ENLITENED Program) [Invited]
Authors: Glick Madeleine , Abrams Nathan C. , Cheng Qixiang , Teh Min Yee , Hung Yu-Han , Jimenez Oscar , Liu Songtao , Okawachi Yoshitomo , Meng Xiang , Johansson Leif , Ghobadi Manya , Dennison Larry , Michelogiannakis George , Shalf John , Liu Alan , Bowers John , Gaeta Alex , Lipson Michal , Bergman Keren 
Published: November 2020

We review the motivation, goals, and achievements of the Photonic Integrated Networked Energy efficient datacenter (PINE) project, which is part of the Advanced Research Projects Agency–Energy (ARPA-E) ENergy-efficient Light-wave Integrated Technology Enabling Networks that Enhance Dataprocessing (ENLITENED) program. The PINE program leverages the unique features of photonic technologies to enable alternative mega-datacenters and high-performance computing (HPC) system architectures that deliver more substantial energy efficiency improvements than can be achieved through link energy efficiency alone. In phase 1 of the program, the PINE system architecture demonstrated an average factor of2.2×improvement in transactions/joule across a diverse set of HPC and datacenter applications. In phase 2, PINE will demonstrate an aggressive 1.0 pJ/bit total link budget with high-bandwidth-density dense wavelength-division multiplexing (DWDM) links to enable additional2.5×or more efficiency gains through deep resource disaggregation.
3 kW high OSNR 1030 nm single-mode monolithic fiber amplifier with a 180 pm linewidth
Authors: Chu Qiuhui , Shu Qiang , Liu Yu , Tao Rumao , Yan Donglin , Lin Honghuan , Wang Jianjun , Jing Feng 
Published: November 2020

In this Letter, the amplified spontaneous emission (ASE) effect of a 1030 nm fiber laser is studied theoretically and, based on the theoretical results, a 3 kW high optical signal-to-noise ratio (OSNR) 1030 nm fiber amplifier with a 180 pm linewidth and near-diffraction-limited beam quality is achieved. A theoretical model, which takes simulate ASE light falling in the range of Raman light as the Raman seed, has been used to optimize the power scaling capability of 1030 nm fiber amplifiers. It shows that the SRS effect seeded by the ASE is the main limiting factor for the fiber amplifiers operating at 1030 nm, and

>

3

k
W

output power with a high OSNR can be achieved by proper parameter designing of the fiber laser system. A 1030 nm monolithic narrow linewidth fiber amplifier, which delivers 3 kW output power with the OSNR being 37 dB and a 0.18 nm spectrum linewidth, has been demonstrated. At the maximum 3 kW output power, the SRS light peak is obviously higher than ASE light, which agrees with the theoretical predictions. Neither a stimulated Brillouin scattering effect nor a thermal-induced mode instability effect has been observed at ultimate power level, and the beam quality factor

M

2

is measured to be less than 1.2. To the best of our knowledge, this is the highest average power for a narrow linewidth single-channel fiber laser system reported so far operating at 1030 nm.
The genesis model of carbonate cementation in the tight oil reservoir: A case of Chang 6 oil layers of the Upper Triassic Yanchang Formation in the western Jiyuan area, Ordos Basin, China
Authors: Li Shutong , Li Shixiang , Zhou Xinping , Ma Xiaofeng , Guo Ruiliang , Zhang Jiaqiang , Chen Junlin 
Published: November 2020

Abstract
Carbonate cementation is one of the significant tightness factors in Chang 6 reservoir of the western Jiyuan (WJY) area. Based on the observation of core and thin sections, connecting-well profile analysis as well as carbon and oxygen isotope analysis, it is found that ferrocalcite is the main carbonate cements in the Chang 6 reservoir of the WJY area. The single sand body controls the development of carbonate cements macroscopically. Both carbonate cements and calcite veins hold similar diagenetic conditions: the dissolution of plagioclase is the main calcium source and the de-acidification of organic acids is the main carbon source. The diagenetic stage is identified as the mesogenetic A stage. The sedimentary environment is of low salinity. Accordingly, the development model of carbonate cementation in Chang 6 reservoir is summarized into three types: “eggshell pattern,” “cutting pattern,” and “favorable reservoir pattern.” The development degree of carbonate cementation affects the physical properties of reservoir.
Analysis of surface deformation and driving forces in Lanzhou
Authors: Wang Wenhui , He Yi , Zhang Lifeng , Chen Youdong , Qiu Lisha , Pu Hongyu 
Published: November 2020

AbstractSurface deformation has become an important factor affecting urban development. Lanzhou is an important location in the Belt and Road Initiative, an international development policy implemented by the Chinese government. Because of rapid urbanization in Lanzhou, surface deformation occurs easily. However, the spatial-temporal characteristics of surface deformation and the interaction of driving forces behind surface deformation in Lanzhou are unclear. This paper uses small baseline subset InSAR (SBAS-InSAR) technology to obtain the spatial-temporal characteristics of surface deformation in Lanzhou based on 32 Sentinel-1A data from March 2015 to January 2017. We further employ a geographical detector (geo-detector) to analyze the driving forces (single-factor effects and multifactor interactions) of surface deformation. The results show that the central urban area of Lanzhou was stable, while there was surface deformation around Nanhuan road, Dongfanghong Square, Jiuzhou, Country Garden, Dachaiping, Yujiaping, Lanzhou North Freight Yard, and Liuquan Town. The maximum deformation rate was −26.50 mm year−1, and the maximum rate of increase was 9.80 mm year−1. The influence factors of surface deformation in Lanzhou was a complex superposition relationship among various influencing factors, not a result of the single factor. The interaction between the built-up area and land cover types was the most important factor behind surface deformation in Lanzhou. This paper provides the reference data and scientific foundation for disaster prevention in Lanzhou.
Comparison between electrical resistivity tomography and tunnel seismic prediction 303 methods for detecting the water zone ahead of the tunnel face: A case study
Authors: Dastanboo Nima , Li Xiao-Qing , Gharibdoost Hamed 
Published: November 2020

Abstract
In deep tunnels with hydro-geological conditions, it is paramount to investigate the geological structure of the region before excavating a tunnel; otherwise, unanticipated accidents may cause serious damage and delay the project. The purpose of this study is to investigate the geological properties ahead of a tunnel face using electrical resistivity tomography (ERT) and tunnel seismic prediction (TSP) methods. During construction of the Nosoud Tunnel located in western Iran, ERT and TSP 303 methods were employed to predict geological conditions ahead of the tunnel face. In this article, the results of applying these methods are discussed. In this case, we have compared the results of the ERT method with those of the TSP 303 method. This work utilizes seismic methods and electrical tomography as two geophysical techniques are able to detect rock properties ahead of a tunnel face. This study shows that although the results of these two methods are in good agreement with each other, the results of TSP 303 are more accurate and higher quality. Also, we believe that using another geophysical method, in addition to TSP 303, could be helpful in making decisions in support of excavation, especially in complicated geological conditions.
Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an Orexin Receptor-Modulated Manner
Authors: Bjorness Theresa E. , Greene Robert W. 
Published: November 2020

AbstractDrug addiction and withdrawal are characterized by sleep disruption, but the effects of sleep disruption on these states are not well characterized. Sleep deprivation (SD) immediately before the cocaine conditioning trials enhanced cocaine conditioned place preference (CPP) in a dose-dependent manner (3, 8 mg/kg but not 15 mg/kg) in mice. SD immediately before the postconditioning test also enhanced cocaine CPP preference in a dose-dependent manner (8 mg/kg, but not 3, 15 mg/kg). Exposure to orexin-receptor antagonism (1 mg/kg SB 334867, an orexin 1 receptor antagonist; OX1R) just before cocaine-conditioning trials or the postconditioning test attenuated SD-enhanced preference. This suggests a potential therapeutic role for the manipulation of the orexin system to mitigate drug seeking, especially in the context of sleep loss before drug exposure.
Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice
Authors: Qu Wenhui , Li Ling 
Published: November 2020

Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor exclusively expressed by microglia in the brain, modulates microglial immune homeostasis. Human genetic studies have shown that the loss-of-function mutations in TREM2 signaling are strongly associated with an elevated risk of age-related neurodegenerative diseases including Alzheimer's disease (AD). Numerous studies have investigated the impact of TREM2 deficiency in the pathogenic process of AD. However, the role of TREM2 in shaping neuronal and cognitive function during normal aging is underexplored. In the present study, we employed behavioral, electrophysiological, and biochemical approaches to assess cognitive and synaptic function in male and female young and aged TREM2-deficient (Trem2−/−) mice compared with age-matched, sex-matched, and genetic background-matched wild-type (WT) C57BL/6J controls. YoungTrem2−/− mice exhibited normal cognitive function and synaptic plasticity but had increased dendritic spine density compared with young WT. Unexpectedly, agedTrem2−/− mice showed superior cognitive performance compared with aged WT controls. Consistent with the behavioral data, agedTrem2−/− mice displayed significantly enhanced hippocampal long-term potentiation (LTP) and increased dendritic spine density and synaptic markers compared with aged WT mice. Taken together, these findings suggest that loss of TREM2 affects the neuronal structure and confers resilience to age-related synaptic and cognitive impairment during non-pathogenic aging.SIGNIFICANCE STATEMENTMicroglia are innate immune cells of the brain that orchestrates neurodevelopment, synaptic function, and immune response to environmental stimuli. Microglial triggering receptor expressed on myeloid cells 2 (TREM2) signaling plays pivotal roles in regulating these functions and loss of TREM2 signaling leads to increased risk of developing age-related neurologic disorders. However, the neurologic role of TREM2 in normal aging is poorly understood. The results of the present study unveil the positive impacts of TREM2 deficiency on cognitive and synaptic function during aging and suggest that TREM2 may exert detrimental effects on neuronal function. The possibility of age-related negative impacts from TREM2 is critically important since TREM2 has emerged as a major therapeutic target for Alzheimer's dementia.
Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence
Authors: Arthurton Lewis , Nahotko Dominik Antoni , Alonso Jana , Wendler Franz , Baena‐Lopez Luis Alberto 
Published: November 2020

AbstractCaspase malfunction in stem cells often precedes the appearance and progression of multiple types of cancer, including human colorectal cancer. However, the caspase‐dependent regulation of intestinal stem cell properties remains poorly understood. Here, we demonstrate that Dronc, the Drosophila ortholog of caspase‐9/2 in mammals, limits the number of intestinal progenitor cells and their entry into the enterocyte differentiation programme. Strikingly, these unexpected roles for Dronc are non‐apoptotic and have been uncovered under experimental conditions without epithelial replenishment. Supporting the non‐apoptotic nature of these functions, we show that they require the enzymatic activity of Dronc, but are largely independent of the apoptotic pathway. Alternatively, our genetic and functional data suggest that they are linked to the caspase‐mediated regulation of Notch signalling. Our findings provide novel insights into the non‐apoptotic, caspase‐dependent modulation of stem cell properties that could improve our understanding of the origin of intestinal malignancies.
Artificial Neural Network and Support Vector Regression Applied in Quantitative Structure-property Relationship Modelling of Solubility of Solid Solutes in Supercritical CO2
Authors: Moussaoui Mohammed , Laidi Maamar , Hanini Salah , Hentabli Mohamed 
Published: November 2020

In this study, the solubility of 145 solid solutes in supercritical CO&lt;sub&gt;2&lt;/sub&gt; (scCO&lt;sub&gt;2&lt;/sub&gt;) was correlated using computational intelligence techniques based on Quantitative Structure-Property Relationship (QSPR) models. A database of 3637 solubility values has been collected from previously published papers. Dragon software was used to calculate molecular descriptors of 145 solid systems. The genetic algorithm (GA) was implemented to optimise the subset of the significantly contributed descriptors. The overall average absolute relative deviation MAARD of about 1.345 % between experimental and calculated values by support vector regress SVR-QSPR model was obtained to predict the solubility of 145 solid solutes in supercritical CO&lt;sub&gt;2&lt;/sub&gt;, which is better than that obtained using ANN-QSPR model of 2.772 %. The results show that the developed SVR-QSPR model is more accurate and can be used as an alternative powerful modelling tool for QSAR studies of the solubility of solid solutes in supercritical carbon dioxide (scCO&lt;sub&gt;2&lt;/sub&gt;). The accuracy of the proposed model was evaluated using statistical analysis by comparing the results with other models reported in the literature.
Chronic atrophic gastritis: an update on diagnosis
Authors: Botezatu Adriana , Bodrug Nicolae 
Published: November 2020

Background and aim. Atrophic gastritis is a precancerous gastric lesion, therefore its early detection is a priority in preventing gastric cancer. The aim of the present paper is to develop a narrative synthesis of the present knowledge on diagnostic methods of chronic atrophic gastritis.
Methods. A literature search was carried out on main databases: PubMed, Hinari, SpringerLink and Scopus (Elsevier) for the period 2000-2020. The searched keywords were: chronic atrophic gastritis, intestinal metaplasia and dysplasia + diagnosis. Inclusion criteria were focused on the articles about the invasive and non-invasive diagnosis of chronic atrophic gastritis and of precancerous gastric lesions, intestinal metaplasia and dysplasia; exclusion criteria were articles published before 2000 and those that did not include the proposed theme.
Results. The search returned 575 papers addressing the topic of precancerous lesions. From these, 60 articles were qualified representative for the materials published on the topic of this synthesis article, being those that met the inclusion criteria. The data emphasize the need to use upper digestive endoscopy with biopsies for the diagnosis of chronic atrophic gastritis. However serological diagnosis is available as alternative mainly recommended in follow up.
Conclusions. There are two main methodological approaches for the evaluation of chronic atrophic gastritis as a precancerous gastric lesions: invasive examination, which requires histological analysis of biopsy samples taken during upper digestive endoscopy, being the "gold standard" for diagnosis, and non-invasive serological examination using markers of gastric function.
Pediatrician Electronic Health Record Time Use for Outpatient Encounters
Authors: Overhage J. Marc , Johnson Kevin B. 
Published: November 2020

BACKGROUND:The time providers spend using their electronic health records (EHRs) delivering care and its potential impact on patient care are of concern for the health care system. In studies to date, researchers have focused on providers who primarily care for adults. Scant information exists for pediatricians. Given this gap, it is important to quantify EHR activity for this group.METHODS:We studied pediatricians practicing in US-based ambulatory practices using the Cerner Millennium EHR by extracting data from software log files in the Lights On Network for the calendar year 2018 and summarizing the time spent on each of 13 clinically-focused EHR functions according to clinical specialty.RESULTS:Our data included &gt;20 million encounters by almost 30 thousand physicians from 417 health systems. Pediatric physicians spent an average of 16 minutes per encounter using their EHR. Chart review (31%), documentation (31%), and ordering (13%) functions accounted for most of the time. The distribution of time spent by providers using their EHR is highly variable within subspecialty but is similar across specialties. Because of data limitations, we were unable to examine geographic or health system–specific variation.CONCLUSIONS:Pediatricians, like physicians who care for adults, spend a large portion of their day using their EHR. Additionally, although chart review and documentation accounted for 62% of the activity, as in previously published studies, in our study, we found that chart review accounted for half of that time. Wide variation suggests opportunities to optimize both the processes of entering information and searching for patient data within the EHR.
Haemagglutination activity of lectins from extracts of some Vietnam marine sponges
Authors: Hung Le Dinh , Thanh Trung Dinh 
Published: November 2020

Aqueous extracts from 16 species of Vietnam marine sponges were examined for haemagglutination activity using native and enzyme-treated different animal and human erythrocytes. Among these, extracts from 14 species were found to have haemagglutinination activities toward at least one type of erythrocyte tested meaning that 87.5% of the surveyed marine sponge species possess haemagglutination activity. Strong activity was detected in extracts from marine sponge species Acanthella cavernosa, Axinyssa sp., Cinachyrella sp., 01NT.2.4, 3.5, 3.10, 3.11 and 3.18 with enzyme-treated various animal and human erythrocytes. In a haemagglutination–inhibition test with various monosaccharides and glycoproteins, haemagglutination activity of the extract from A. cavernosa had no affinity for any of the monosaccharides, but inhibited by porcine stomach mucin and fetuin, whereas activities of the extract from Cinachyrella sp. were strongly inhibited by monosaccharides, such as D-galactose and N-acetyl-D-galatosamine, but not with glycoproteins. The activity of Stylissa flexibilis extract was inhibited by D-galactose, porcine stomach mucin, fetuin and their asialo derivatives, suggesting the presence of lectin specific for O-glycans of this species. The activities of four sponge extracts from A. cavernosa, S. flexibilis, Axinyssa sp. and Cinachyrella sp. were stable over a wide range of pH and temperature. Haemagglutination activities of A. cavernosa, Axinyssa sp. and Cinachyrella sp. extracts were independent of the presence of divalent cations, except for the haemagglutination activity of extract from S. flexibilis, which was dependent on the presence of divalent cations. The results suggest that Vietnam marine sponges may be good sources of useful lectins for biochemical and biomedical applications.
A Fictitious States: past and present
Authors: Novoseltsev Alexey Yu. , Stepanyugin Konstantin V. 
Published: November 2020

The article discusses the concept of a fictitious state, which can be defined as an international legal fiction that is created or consciously supported by real actors in international relations to legitimize illegal actions, such as annexation, evasion of obligations, seizing the assets of other states, creating a buffer zone, etc.
The main feature of a fictitious state is the absence of real sovereignty in the presence of only external attributes of the state. The authors believe that fictitious states are a facet of neocolonialism. Although the number of states in the world has increased from 70 to 197 since 1945, this figure has no relation to the self-determination of peoples.
The authors conclude that at present there are no legal requirements for the legal capacity of subjects of international law. Condemnation or recognition of fictitious states, as before, is determined solely by the interests of foreign policy. The authors propose to continue work on strengthening the sovereignty of the Russian Federation at the level of national legislation.