bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban environment and mental health: the NAMED project, protocol for a mixed-method study
Authors: Lauwers Laura , Trabelsi Sonia , Pelgrims Ingrid , Bastiaens Hilde , De Clercq Eva , Guilbert Ariane , Guyot Madeleine , Leone Michael , Nawrot Tim , Van Nieuwenhuyse An , Remmen Roy , Saenen Nelly , Thomas Isabelle , Keune Hans 
Published: February 2020

IntroductionMental health issues appear as a growing problem in modern societies and tend to be more frequent in big cities. Where increased evidence exists for positive links between nature and mental health, associations between urban environment characteristics and mental health are still not well understood. These associations are highly complex and require an interdisciplinary and integrated research approach to cover the broad range of mitigating factors. This article presents the study protocol of a project called Nature Impact on Mental Health Distribution that aims to generate a comprehensive understanding of associations between mental health and the urban residential environment.Methods and analysisFollowing a mixed-method approach, this project combines quantitative and qualitative research. In the quantitative part, we analyse among the Brussels urban population associations between the urban residential environment and mental health, taking respondents’ socioeconomic status and physical health into account. Mental health is determined by the mental health indicators in the national Health Interview Survey (HIS). The urban residential environment is described by subjective indicators for the participant’s dwelling and neighbourhood present in the HIS and objective indicators for buildings, network infrastructure and green environment developed for the purpose of this project. We assess the mediating role of physical activity, social life, noise and air pollution. In the qualitative part, we conduct walking interviews with Brussels residents to record their subjective well-being in association with their neighbourhood. In the validation part, results from these two approaches are triangulated and evaluated through interviews and focus groups with stakeholders of healthcare and urban planning sectors.Ethics and disseminationThe Privacy Commission of Belgium and ethical committee from University Hospital of Antwerp respectively approved quantitative database merging and qualitative interviewing. We will share project results with a wide audience including the scientific community, policy authorities and civil society through scientific and non-expert communication.
Tackling frailty at primary care: evaluation of the effectiveness of a multicomponent intervention through a randomised controlled trial: study protocol
Authors: Rivas-Ruiz Francisco , Machón Mónica , Mateo-Abad Maider , Contreras-Fernández Eugenio , Güell Carolina , Baro-Rodríguez Luis , Vrotsou Kalliopi , Quirós-López Raúl , Vergara Itziar 
Published: February 2020

IntroductionThis project focuses on how frailty is addressed in primary healthcare (PHC) and will evaluate the effectiveness of a multifactorial intervention (considering the appropriateness of the pharmaceutical prescription, the nutritional care provided and the exercise intervention) for persons with frailty, in terms of improving their functional capacity and reducing the incidence of adverse events related to frailty. The final evaluation will be made at 12 months’ follow-up.Methods and analysisPragmatic multicentre cluster randomised controlled clinical trial, single blind with two arms: multifactorial intervention in PHC versus usual follow-up. The randomisation unit is the patient list and the analysis unit is the patient. In addition, a cost-effectiveness study and a qualitative study will be carried out, the latter based on semistructured interviews and focus groups. Two hundred persons (100 per study branch) all aged ≥70 years, presenting frailty, but functionally independent and resident in the community, will be recruited. A baseline evaluation will be carried out prior to the intervention, with follow-up at 6 and 12 months. The main study variables considered will be functional capacity and incidence of adverse events; the secondary variables considered will be the patients’ sociodemographic characteristics, nutritional status, level of physical activity and drug consumption, together with data on comorbidity, cognitive and affective status and health-related quality of life. Data will be analysed according to the intention-to-treat principle using a 5% significance level.Ethics and disseminationThe study will at all times be conducted in strict accordance with the provisions of the Declaration of Helsinki and with the national legislation regulating patients’ autonomy. All patients recruited will be asked to provide written informed consent before taking part in the clinical trial. On completion of the study, the principal investigator expects to publish the results of this research in a peer-reviewed open access scientific journal.Trial registration numberISRCTN17143761.
Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial
Authors: Kiel Ida Almenning , Lionett Sofie , Parr Evelyn Bridget , Jones Helen , Røset Maria Aurora Hernandez , Salvesen Øyvind , Vanky Eszter , Moholdt Trine 
Published: February 2020

IntroductionPolycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and the leading cause of anovulatory infertility. Women with PCOS have a 15-fold higher prevalence of infertility, compared with women without PCOS, independent of body mass index (BMI). A healthy lifestyle is recommended to improve overall health and fertility in PCOS but there is limited evidence on the isolated effects of exercise, especially for reproductive outcomes. Previous findings indicate superior metabolic health benefits after vigorous compared with moderate-intensity exercise. Our primary aim is to determine the effect of high-intensity interval training (HIT) on menstrual frequency, as a proxy of reproductive function, in women with PCOS.Methods and analysisThe study is a two-centre, randomised, controlled trial with three parallel groups. Women (n=64) from Trondheim (Norway) and Melbourne (Australia) with PCOS according to the Rotterdam criteria will be randomly allocated (1:1:1) to high-volume HIT, low-volume HIT or a control group with no exercise after stratifying for BMI < or ≥ 27 kg/m2and study centre. Measurements for study end points will be undertaken at baseline, after a 16 week exercise intervention and at 12 months following baseline assessments. The primary outcome measure is menstruation frequency, measured as the number of self-reported menstrual bleedings divided by the number of expected menstrual bleedings during a 12-month period. Secondary outcome measurements include markers of cardiovascular, metabolic and reproductive health, as well as quality of life and adherence to and enjoyment of exercise.Ethics and disseminationThe Regional Committee Medical Research Ethics, Norway, and The Australian Catholic University Human Research Ethics Committee, Australia, have approved the trial protocol. This trial will provide new insight regarding the impact of exercise on fertility in PCOS. We expect this trial to contribute to new therapeutic exercise strategies as part of clinical care for women with PCOS.Trial registration numberClinical trial govNCT02419482.
Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
Authors: Dearing Marci Elizabeth , Bowles Susan , Isenor Jennifer , Kits Olga , Kouladjian O'Donnell Lisa , Neville Heather , Hilmer Sarah , Toombs Kent , Sirois Caroline , Hajizadeh Mohammad , Negus Aprill , Rockwood Kenneth , Reeve Emily 
Published: February 2020

IntroductionPolypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations.Methods and analysisThis study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Burden Index (DBI) Calculator) in four hospital sites in the Canadian province of Nova Scotia. The study aims to enrol 160 participants between the preintervention and intervention groups. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2013 checklist) was used to develop the protocol for this prospective interventional implementation study. A preintervention retrospective control cohort and a multiple case study analysis will also be used to assess the effect of intervention implementation. Statistical analysis will involve change in DBI scores and assessment of clinical outcomes, such as rehospitalisation and mortality using appropriate statistical tests including t-test, χ2, analysis of variance and unadjusted and adjusted regression methods.Ethics and disseminationEthics approval has been granted by the Nova Scotia Health Authority Research Ethics Board. The findings of this study will be published in peer-reviewed journals and presented at local, national and international conferences.Trial registration numberNCT03698487.
Sizing of ballistic arm protection for the VIRTUS body armour and load carriage system
Authors: Breeze Johno , Davis J I , Fryer R N , Lewis E A 
Published: February 2020

IntroductionSevere haemorrhage from the arm that is unresponsive to direct pressure necessitates the application of a tourniquet. Detachable arm protection, referred to as brassards, are used by the UK Armed Forces to protect the upper arm from fragmentation threats. However, the coverage they originally provided was based on limited medical evidence. Medical consensus has determined that the dimensions of arm protection should in future be related to how far up the arm a tourniquet can be applied.MethodCT scans of 120 male Armed Forces personnel were analysed to ascertain the vertical distances from acromion process to the point at which a tourniquet can applied, equating to the anterior axillary fold. These values were statistically compared with those derived from the 2007 UK Military anthropometric survey using a paired t-test. Additional distances were added to account for tourniquet width and slippage, with the total value compared with VIRTUS brassard length.ResultsNo significant difference (p<0.01) was found in mean acromion to axilla length (114 mm) compared with that found in the anthropometric survey confirming sample validity. The deltoid insertion lay 24 mm below the axillary fold for the 50th percentile value from CT. Essential arm coverage for the 99th percentile male in this study was calculated as 201 mm.ConclusionsBased on this research, a single new brassard for the VIRTUS body armour and load carriage system was recommended and manufactured based on the 99th percentile. This is over 30% shorter than the existing VIRTUS brassard, reducing the overall weight burden for the soldier and improving heat dispersion, integration and interoperability. The new brassard has been issued to Armed Forces personnel since October 2018. The reduced mass of ballistic protective material in conjunction with requiring only a single size of brassard has already saved the Ministry of Defence £20 000 in procurement costs.
Is there any association between dietary patterns, food security status and psychiatric disorders among Iranian earthquake victims?
Authors: Janmohammadi Parisa , Daneshzad Elnaz , Alipour Tanaz , Heshmati Javad , Eshaghi Hesam , Mirzaei Khadijeh 
Published: February 2020

BackgroundDiet changes through disasters may affect psychological health as well as general health. The present study aimed to find food security status—that is defined by having enough food for an active, healthy life—dietary patterns and their relationship with probable psychiatric disorders in earthquake survivors.MethodsThis cross-sectional study conducted on 350 women who survived in East Azarbaijan earthquake (At 4:53 am on 11 August 2012). Food frequency questionnaire, Depression, Anxiety and Stress Scale and food security questionnaire of the US Department of Agriculture were used to assess dietary patterns, psychological and food security status, respectively. P values were considered significant at <0.05.ResultsFour major dietary patterns were defined based on factor analysis. These four dietary patterns explained of 37.09% variation of food intakes. Ten per cent of the population was food secure. There was no significant association between tertiles of major dietary patterns and risk of all psychological disorders (p values>0.05).ConclusionThere was no statistically significant association between major dietary patterns and psychiatric disorders. Further well-designed studies need to find any significant association.
Surgical rehabilitation of terror-related open globe injuries in the Turkish Military: long-term results
Authors: Guven Soner 
Published: February 2020

IntroductionThe purpose of this study is to evaluate the factors affecting multiple surgeries, worse visual outcome, eye removal (ER) and vitrectomy requirement in terror-related open-globe injuries (OGI) in the Turkish Military. Secondary purpose is to specify surgery and injury characteristics of terror-related OGI.MethodsA total of 372 eyes of 251 patients with OGI that occurred during terroristic attacks between January 1996 and January 2016 were included in the study. A retrospective investigation of the preoperative variables associated with further surgeries, visual outcome, vitrectomy requirement and evisceration/enucleation was achieved.ResultsA total of 1118 separate operative sessions with a median of 2 (1–14) surgeries were performed to 372 eyes. Preoperative factors predicting follow-up surgery included visual acuity (VA) <20/200, lens injury, vitreous haemorrhage (VH), presence of vitreous prolapse. Baseline VA <20/200, initial retinal detachment and ruptured globe injury were the independent factors of worse visual result. Ruptured globe injury (p:0.000) and initial vitreous prolapse (p:0.001) were significantly linked to ER surgery. Patients required vitrectomy significantly tend to have VH (p:0.000) and zone 3 injury (p:0.000) compared with non-vitrectomy group. Single surgery cases tend to have significantly better baseline (p:0.000) and final VA (p:0.007) and shorter follow-up period (p:0.000) compared with multiple surgery group.ConclusionsTerror-related OGI necessitate remarkable surgical follow-up and multiple surgery sessions with a relatively higher evisceration/enucleation rate than other types of OGI. A comprehensive surgical approach with multiple surgery types is needed to treat terror-related OGI.
Resting heart rate and incident venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis
Authors: Awotoye Josephine , Fashanu Oluwaseun E , Lutsey Pamela L , Zhao Di , O'Neal Wesley T , Michos Erin D 
Published: February 2020

ObjectiveVenous thromboembolism (VTE) is associated with significant morbidity and mortality. Resting heart rate (RHR), which may be modifiable through lifestyle changes, has been shown to be associated with cardiovascular disease risk and with inflammatory markers that have been predictive of VTE incidence.MethodsWe examined whether RHR is also associated with VTE incidence independent of these risk factors. We studied 6479 Multi-Ethnic Study of Atherosclerosis participants free from clinical VTE at baseline who had baseline RHR ascertained by 12-lead ECG. VTE events were recorded from hospital records and death certificates using International Classification of Diseases (ICD)-9 and ICD-10 codes. We categorised RHR as <60, 60–69, 70–79 and ≥80 bpm. We used Cox hazard models to determine the association of incident VTE by RHR.ResultsParticipants had mean (SD) age of 62 (10) years and RHR of 63 (10) bpm. RHR was cross-sectionally correlated with multiple inflammatory and coagulation factors. There were 236 VTE cases after a median follow-up of 14 years. Compared with those with RHR<60 bpm, the HR (95% CI) for incident VTE for RHR≥80 bpm was 2.08 (1.31 to 3.30), after adjusting for demographics, physical activity, smoking, diabetes and use of atrioventricular (AV)-nodal blockers, aspirin and anticoagulants, and remained significant after further adjustment for inflammatory markers (2.05 (1.29 to 3.26)). Results were similar after excluding those taking AV-nodal blocker medications. There was no effect modification of these associations by sex or age.ConclusionElevated RHR was positively associated with VTE incidence after a median of 14 years; this association was independent of several traditional VTE and inflammatory markers.
Costs of vaping: evidence from ITC Four Country Smoking and Vaping Survey
Authors: Cheng Kai-Wen , Shang Ce , Lee Hye Myung , Chaloupka Frank J , Fong Geoffrey T , Borland Ron , Heckman Bryan W , Hitchman Sara C , O'Connor Richard J , Levy David T , Cummings K. Michael 
Published: February 2020

Study objectivesTo compare the prices paid for nicotine vaping products (NVPs) and supplies among current NVP users to prices paid for cigarettes among current smokers.DataThe 2016 International Tobacco Control Four Country Vaping and Smoking Survey (4CV1). Key measures included: (1) self-reported prices paid for reusable NVPs (eg, rechargeable devices with cartridges and tank system devices with e-liquids) in the 3-month period prior to the survey among current NVP users, (2) prices paid for disposable NVPs, cartridges and e-liquids purchased in the last 30 days among current NVP users and (3) self-reported prices paid for cigarettes among current smokers.ResultsDisposable NVP price was higher than the price of a comparable unit for combustible cigarettes in England (EN), USA and Canada (CA). Prefilled cartridge price was higher than the price of a comparable unit of cigarettes in USA and CA, but lower in EN and Australia. E-liquid price was consistently lower than the price of a comparable unit of cigarettes across four countries. For start-up costs, price of a rechargeable device is approximately 3–5 times higher than a pack of cigarettes in four countries.ConclusionNVP prices were generally higher than prices of combustible cigarettes, especially the high upfront NVP devices. The high upfront costs of purchasing a reusable NVP may discourage some smokers from switching to vaping. However, the average lower costs of cartridges and e-liquids relative to a package of cigarettes make switching to a NVP an attractive alternative to smoking in the long term so long as smokers switch completely to vaping.
Application of autologous cortical bone grafts for femoral non‐union fractures in two dogs
Authors: Muroi Norihiro , Kanno Nobuo , Suzuki Shuji , Harada Yasuji , Hara Yasushi 
Published: February 2020

Two dogs with non‐union fractures and osteomyelitis in the femoral diaphysis were referred to the authors’ hospital. During surgery, the defects were reconstructed using autologous cortical bones harvested from the contralateral femoral diaphysis. Graft fixation was performed by a double‐plate technique in both cases. Autogenous cancellous bone was also grafted between the host bone and the graft in both cases. Antibiotics were administered for two to three weeks. In cases 1 and 2, no loosening of the implant or lameness was observed after 31 months and 10 months, respectively. Autologous cortical bone grafts are useful in reconstructing large‐sized bone defects of the femoral diaphysis associated with non‐union fracture and osteomyelitis.
Perinatal mortality in 23 beef herds in Orkney: incidence, risk factors and aetiology
Authors: Norquay Rhona , Orr Jayne , Norquay Bob , Ellis Kathryn Amanda , Mee John F , Reeves Aaron , Scholes Sandra , Geraghty Tim 
Published: February 2020

BackgroundPerinatal mortality in beef calves impacts on profitability and animal welfare, but the incidence and causes in UK herds are not well known.MethodsData from 11 herds were analysed to establish the risk factors for and incidence of perinatal mortality (full‐term calves born dead or died within 48 hours). To establish cause of death, 23 herds in total submitted dead calves for postmortem examination (nine herds submitted all calves, 14 herds submitted calves on an ad hoc basis) and the results were reviewed by a panel.ResultsThe incidence of perinatal mortality for all 1059 calvings was 5.1 per cent (range 1.6–12.4 per cent across herds; median 4 per cent). The incidence of stillbirth and neonatal mortality was 3.9 per cent (range 0–10.1 per cent) and 1.2 per cent (range 0–2.6 per cent), respectively. Sex of the calf, plurality and level of calving assistance were associated with significantly greater risk of perinatal loss. Parturition‐related deaths (n=20), intrauterine infections (n=13), congenital malformations (n=6) and postpartum infections (n=6) were among the diagnosis recorded from 54 calves investigated. Parturition‐related deaths and congenital malformations were recorded more commonly from herds submitting all losses than from those submitting on an ad hoc basis.ConclusionVariation in perinatal incidence across herds exists and many fail to reach the 2 per cent target. Some significant risk factors and common causes of death identified have the potential to decrease perinatal mortality rates through improved herd management.
Effects of dietary mulberry leaf powder on growth performance, blood metabolites, meat quality, and antioxidant enzyme-related gene expression of fattening Hu lambs
Authors: Ouyang Jialiang , Hou Qirui , Wang Mengzhi , Zhao Weiguo , Feng Dan , Pi Yu , Sun Xuezhao 
Published: February 2020

This study was conducted to investigate the effects of the mulberry [Morus alba var. multicaulis (Perrott.) Loud.] leaf powder (MLP) supplementation in dietary concentrates on growth performance, blood metabolites, meat quality, and antioxidant enzyme (AOE) gene expression in fattening Hu lambs. Forty approximately 3-mo-old Hu lambs (16.5 ± 0.6 kg) were randomly allocated to five groups and fed with concentrates containing 0%, 15%, 30%, 45%, or 60% MLP (control, T15, T30, T45, and T60, respectively). The results showed that 15%–30% MLP supplementation maintained growth and carcass performance, and the weight of total stomach, especially of rumen in T15 and T30, were higher than those of the control. Dietary MLP supplementation decreased serum aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, cholesterol, and triglyceride levels, but increased the high-density lipoprotein levels. Moreover, MLP supplementation improved the longissimus lumborum muscle color (redness), tenderness, and water-holding capacity. It was further observed that 15% MLP supplementation enhanced all AOE mRNA levels apart from that of EPHX1. In summary, dietary MLP supplementation could partially improve the blood metabolites, meat quality, and AOE mRNA levels in the liver of fattening Hu lamb, and the level of 15% supplementation was the most promising.