bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Impact of Oral Health on Geriatric Syndromes and Clinical Outcomes in Community-dwelling Older Adults
Authors: Lim Jihye , Park Hyungchul , Lee Heayon , Lee Eunju , Lee Danbi , Jung Hee-Won , Jang Il-Young 
Published: December 2020

Abstract
BackgroundOral health is essential for daily living and plays a pivotal role in overall health conditions and well-being. This study evaluated the impact of self-reported oral health on geriatric conditions, institutionalization, and mortality. MethodsThis study analyzed the population of the Aging Study of Pyeongchang Rural Area that had undergone geriatric assessments between 2016 and 2017. The oral health status of the participants was determined using three items from the General Oral Health Assessment Index, and the participants were classified into three groups according to the total sum of the scores as good (3), fair (4–7), or poor (8-15). The outcomes were the incidence of geriatric syndromes at 2 years and the composite outcome of mortality and institutionalization.ResultsAmong the 1189 participants, 44.1% were women, and the mean age of the study population was 75.0 years. Good, fair, and poor oral health were observed in 597 (50.2%), 406 (34.1%), and 186 (15.6%) individuals, respectively. Worsening oral health status was associated with the incidences of various geriatric syndromes at follow-up, and these associations were attenuated after adjusting for baseline demographic and geriatric parameters. Similarly, the significant association between baseline oral health status and the incidence of the composite outcome was attenuated after adjusting for demographic and geriatric parameters. ConclusionsOral health affected the geriatric health conditions in this prospective, longitudinal cohort of community-dwelling older adults. The correlations and interactions of oral health status with other functional parameters may deserve consideration as a geriatric domain.
Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis: Spanish RA-ILD cohort
Authors: Cano-Jiménez Esteban , Rodríguez Tomás Vázquez , Martín-Robles Irene , Villegas Diego Castillo , García Javier Juan , de Miguel Elena Bollo , Robles-Pérez Alejandro , Galván Marta Ferrer , Roibas Cecilia Mouronte , Lara Susana Herrera , Bermudo Guadalupe , Moyano Marta García , Portal José Antonio Rodríguez , Torres Jacobo Sellarés , Molina-Molina María 
Published: December 2020

Abstract
Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. Methods: A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD between 2013 and 2018. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. Results: 106 patients were included. The mean age was 70.2±19.8 years and 51.9% of the patients presented UIP pattern. In the multivariate Cox analysis the age (HR 1.33, 95% CI 1.09-1.62, p=0.0045), the DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p=0.0246), and the final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p=0.0465) were independent predictor variables of mortality, as well as the GAP index (HR 4.65, 95% CI 1.59 - 13.54, p=0.0051) and the CPI index (HR 1.12, 95% CI 1.03 - 1.22, p=0.0092). Also highlight that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Conclusions: This is the first study where it is objectified that the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF.
Randomized, Double-Blind, Four-Arm Pilot Study on the Effects of BRAND'­­­­­­S Chicken Essence and FlexC-II® on Joint, Bone, and Muscle Functions
Authors: Chen Chun-Chieh , Chang Shih-Sheng , Chang Chih-Hsiang , Hu Chih-Chien , Nakao Yoshihiro , Yong Shan May , Mandy Yen Ling Ow , Shih Hsin-Nung 
Published: December 2020

Abstract
BackgroundKnee osteoarthritis (OA) is a leading cause of disability among elderly individuals. Medical and surgical treatments are expensive and have side eﬀects. The current study aimed to investigate the efficacy and safety of FlexC-II®, a type II collagen hydrolysate, and BRAND'S Essence of Chicken with FlexC-II® (BEC-FlexC-II®) on joint, muscle, and bone functions among elderly adults with OA.MethodsPatients (n = 160) with grade 1–3 knee OA based on the Kellgren–Lawrence classification system, joint pain for ≥3 months, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score of >6 were considered eligible in this study. The participants were randomized into four groups (BEC-FlexC-II®, FlexC-II®, glucosamine hydrochloride [HCl], and placebo) and were instructed to perform resistance training for 24 weeks. The outcomes included WOMAC score, visual analogue scale (VAS) score, hand grip strength, fat-free mass (FFM), bone mass, and 36-Item Short-form Survey score. ResultsThe WOMAC scores of all groups improved after 24 weeks. However, the results did not significantly differ. Meanwhile, there was a remarkable difference in the VAS score between groups (P = 0.039). The FlexC-II® group had a greater reduction in pain than the placebo group (mean ± standard error: −1.3 ± 0.45, P = 0.021). In the FlexC-II® group, the VAS score significantly reduced by 0.9 ± 1.89 (P = 0.034) after 14 days. In the adjusted analyses, the BEC-FlexC-II® group had a significantly higher FFM than the glucosamine HCl (P = 0.02) and placebo (P = 0.017) groups and hand grip strength than the glucosamine HCl group (P = 0.002). Further, on the basis of a subgroup analysis, participants with poor training compliance in the BEC-FlexC-II® group had a significantly higher left hip bone mass than those in the placebo (P = 0.01) and glucosamine HCl (P = 0.049) groups.ConclusionsFlexC-II® relieves OA-associated pain within 14 days, and BEC-FlexC-II® increases muscle mass and strength after 24 weeks. Thus, BEC-Flex-CII® is a promising novel, holistic supplement that can improve mobility by promoting joint, muscle, and bone functions among elderly individuals. However, full-scale studies should be conducted in the future to validate these findings.Trial registrationThis clinical trial was retrospectively registered in ClinicalTrials.gov with the ID NCT04483024 on July 20, 2020. URL: https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0008FK4&selectaction=Edit&uid=U0004BM2&ts=2&cx=-5y1oh4
Analysis of the Space and Time Distribution of Syphilis in Brazil: Cases of Acquired Syphilis from 2010-2018 and Congenital and Syphilis in Pregnant Women from 2001-2017
Authors: Silva Ângelo Antônio Oliveira , Leony Leonardo Maia , Souza Wayner Vieira de , Freitas Natália Erdens Maron de , Daltro Ramona Tavares , Santos Emily Ferreira dos , Vasconcelos Larissa de Carvalho Medrado , Grassi Maria Fernanda Rios , Regis-Silva Carlos Gustavo , Santos Fred Luciano Neves 
Published: December 2020

Abstract
Background. In Brazil, the notification of acquired syphilis (AS), congenital syphilis (CS) and syphilis in pregnant women (SiP) is compulsory. Notification data provided by the Ministry of Health (MoH) in combination with the mapping of vulnerable geographic areas is essential to forecasting possible outbreaks and more effectively combating infection through monitoring. We aim evaluated the space and time distribution of reported cases of CS and SiP in Brazil (2001 to 2017), as well as an estimation of cases of AS (2010 to 2018). Methods. A retrospective ecological study was carried out using secondary surveillance data obtained from the Brazilian National Notifiable Diseases Information System (SINAN) database, considering all reported cases of CS and SiP between 2002 to 2017, as well as MoH epidemiological bulletin data regarding cases of AS between 2010 to 2018. Epidemiological characteristics and time trends were analyzed using joinpoint regression models and spatial distribution (three-year moving averages), considering microregions or states/macroregions as units of analysis. Results. A total of 188,630 (5.4/100,000) CS, 235,895 SiP (6.3/100,000) and 479,731 cases of AS (27.4/100,000) were reported during the periods studied. The epidemiological profile of Brazil indicates most reported CS cases occurred among ‘mixed-race’ newborns who were diagnosed within seven days after birth and whose mothers had received prenatal care. Regarding SiP, most cases were among women who self-reported ‘mixed-race’, were aged 20–39 years, had up to eight years of formal education and were diagnosed with primary or latent syphilis. Overall, rates of AS rose around 400% from 2010 to 2018. Nearly all microregions reported at least one case of CS and SiP. From 2012 to 2016, CS cases increased significantly in almost all Brazilian states, most notably in the South, Southeast, and Central-West macroregions, from 2001–2018 and the relative risk of SiP increased around 4,000%. Conclusions. Considering the epidemiological scenario of the infection in Brazil, it is necessary to enhance preventive, control and eradication measures.
Use of insecticide treated nets among women in Ghana: a multilevel modelling of the 2016 malaria indicator survey
Authors: Dadzie Louis Kobina , Blay Alfred , Afari Francis Obeng , Seidu Abdul-Aziz , Ahinkorah Bright Opoku 
Published: December 2020

Abstract
Background

Malaria is among the leading causes of morbidity and mortality particularly among women and children in sub-Saharan Africa and remains a public health challenge. Over the years, provision of insecticide mosquito nets (ITNs) for individuals and households have been on the forefront of various organizations. Focus has been on proportion of population with access to ITNs at the expense of usage proportion. This study examined the factors associated with the use of ITNs among women in Ghana.
Methods

This study used a cross-sectional data obtained from the 2016 Ghana Malaria Indicator Survey (GMIS). A sample of 4,267 women aged 15–49 who possessed at least one mosquito net was included in this study. Use of ITNs was the outcome variable. Descriptive statistics and multilevel binary logistic regression were employed. Results were provided in tables with a significance level set at P < 0.05.
Results

Out of the 4,267 total sample, more than half (55.9%) were users of ITNs. Women aged 15–24 were less likely (aOR = 0.680 Crl:0.576–0.803) to use ITNs compared to women aged 35 years and above. Women with no education were more likely (aOR = 1.282 Crl:1.047–1.570) to use ITNs compared to women with secondary or higher educational level. Poor women also had significantly higher odds (aOR = 2.005 Crl:1.612–2.495) of using ITNs than similar women who were rich. Women who lived in least disadvantaged communities had higher odds (aOR = 1.358 CrI:1.055–1.748) of using ITNs compared to women in most disadvantaged communities.
Conclusions

Low socio-economic status was a key predictor of ITN usage in Ghana. Having no education, being poor, living in rural areas, chances of getting malaria, coverage of malaria under NHIS and being least socio-economically disadvantaged increased the likelihood of using ITNs. Interventions aimed at improving socio-economic statuses are needed to increase ITN usage in Ghana.
High MEIS3 expression intimates poor prognosis for clinical stage II/III colorectal cancer patients
Authors: Jian Ma , Li Haitao , Wang Meihua , Chen Jian , Zhu Ming , Li Ang , Ling Yang 
Published: December 2020

Abstract
Background
The middle stages colorectal cancer (CRC) patients are severely differentiated, so suitable biomarkers are required to distinguish the cohort with high recurrence risk. We hypothesized that among the specimens retained after surgery, those from cohort who relapsed quickly after surgery may be more capable to find the high-risk markers.
Methods
A lable-free analysis was employed to identify candidate proteins markers in CRC tissues relapsed within three years since surgery. Combined with MEIS3 immunohistochemistry characteristic, we analyzed MEIS3 (myeloid ecotropic viral insertion site 3) expression level in clinical stages. Kaplan-Meier Analysis was adopted to analyze the correlation between gene expression and 5-year disease-free survival (DFS) of CRC patients. Finally, cell biology methods were employed to analyze molecular mechanism for tumor cell migration and metastasis.
Results
Through proteomics immunohistochemistry analysis, we identified protein MEIS3 are mainly located in growth front and other highly invasive areas in cancer. And its expression level is closely associated to the clinical stage of CRC. Furthermore, high MEIS3 expression in cancer tissues is closely related to the 5-year DFS expectations of CRC patients. The 5-year DFS of stage II patients with high MEIS3 expression was significantly lower than that of low MEIS3 expression (60.2% % vs 81.1% p < 0.01). The 5-year DFS III patients with high MEIS3 expression was also significantly lower than those of low MEIS3 expression (38.1% vs 56.7% p < 0.01). The analysis on SW480 cells showed that MEIS3 may promote migration and invasion of CRC cells by regulating the expression of LAMB1.
Conclusion
This study intimates that MEIS3 overexpression is associated to poor prognosis for stage II and III patients, and MEIS3 can promote the CRC cells invasion through regulating LAMB1 expression.
The Iron-Sulfur Scaffold Protein HCF101 Unveils The Complexity of Organellar Evolution in SAR, Haptista and Cryptista
Authors: Pyrih Jan , Žárský Vojtech , Fellow Jastin D. , Grosche Christopher , Wloga Dorota , Striepen Boris , Maier Uwe G. , Tachezy Jan 
Published: December 2020

Abstract
Background: Nbp35-like proteins (Nbp35, Cfd1, HCF101, Ind1, and AbpC) are P-loop NTPases that serve as components of iron-sulfur cluster (FeS) assembly machineries. In eukaryotes, Ind1 is present in mitochondria, and its function is associated with the assembly of FeS clusters in subunits of respiratory Complex I, Nbp35 and Cfd1 are the components of the cytosolic FeS assembly (CIA) pathway, and HCF101 is involved in FeS assembly of photosystem I in plastids of plants (chHCF101). The AbpC protein operates in Bacteria and Archaea. To date, the cellular distribution of these proteins is considered to be highly conserved with only a few exceptions. Results: We searched for the genes of all members of the Nbp35-like protein family and analyzed their targeting sequences. Nbp35 and Cfd1 were predicted to reside in the cytoplasm with some exceptions of Nbp35 localization to the mitochondria; Ind1was found in the mitochondria, and HCF101 was predicted to reside in plastids (chHCF101) of all photosynthetically active eukaryotes. Surprisingly, we found a second HCF101 paralog in all members of Cryptista, Haptista, and SAR that was predicted to predominantly target mitochondria (mHCF101), whereas Ind1 appeared to be absent in these organisms. We also identified a few exceptions, as apicomplexans possess mHCF101 predicted to localize in the cytosol and Nbp35 in the mitochondria. Our predictions were experimentally confirmed in selected representatives of Apicomplexa (Toxoplasma gondii), Stramenopila (Phaeodactylum tricornutum, Thalassiosira pseudonana), and Ciliophora (Tetrahymena thermophila) by tagging proteins with an transgenic reporter. Phylogenetic analysis suggested that chHCF101 and mHCF101 evolved from a common ancestral HCF101 independently of the Nbp35/Cfd1 and Ind1 proteins. Interestingly, phylogenetic analysis supports rather a lateral gene transfer of ancestral HCF101 from bacteria than its acquisition being associated with either α- proteobacterial or cyanobacterial endosymbionts. Conclusion: Our searches for Nbp35-like proteins across eukaryotic lineages revealed that SAR, Haptista, and Cryptista possess mitochondrial HCF-101. Because plastid localization of HCF101 was only known thus far, the discovery of its mitochondrial paralog explains confusion regarding the presence of HCF101 in organisms that possibly lost secondary plastids (e.g., ciliates, Cryptosporidium) or possess reduced nonphotosynthetic plastids (apicomplexans).
Tissue Immunofluorescence Confirmation of CNS Autoantibodies Identified by Immunoblot or Cell-Based Assay
Authors: Abelhosn Rania W. , Montana Laura , Rivera Jonnielyn G. , Haji-Sheikhi Farnoosh , Diao Joanne H. , Tran Harley H. , Levy Michael , Horner Anthony A. 
Published: December 2020

Abstract
Background: While many immunologic targets of autoimmune CNS disease have been identified, autoantibodies to each, are detected only rarely. Therefore, serum is often screened by immunofluorescence assay (IFA) with whole brain tissue before reflexing positive samples to more specific assays for confirmation and identification. The purpose of this study was to compare the sensitivity of immunofluorescence positive staining of whole brain tissue to immunoblot assays (IBAs) and cell-based immunofluorescence assays (CBAs) for the initial detection of autoantibodies associated with paraneoplastic syndrome (PNS) and other autoimmune diseases of the CNS.Methods: All comprehensive paraneoplastic neurological syndrome panel results released from our laboratory over a two-year period (2017-2019) were reviewed. This panel was specifically chosen for these retrospective analyses because of the comprehensive PNS panel’s design; a reflex testing algorithm is not used and a tissue IFAs, IBAs, and CBAs, are run in parallel and independently on all serum samples. Results: For autoantibodies to intracellular targets, tissue IFA results were positive for 47 of 56 (84%) samples that were positive by IBA. In contrast, for autoantibodies to membrane-imbedded antigenic targets, tissue IFA results were positive for only 5 of 14 (35.7%) samples that were positive by CBA.Conclusions: These retrospective analyses suggest that tissue IFAs of serum are more than twice as likely to confirm the presence of IBA identified autoantibodies to intracellular proteins than CBA identified autoantibodies to membrane imbedded protein targets. Moreover, these findings have important implications for the use of tissue IFA screening for the initial detection of CNS autoantibodies.
Factors That Affect Post-traumatic Growth in Korean Police Officers, by Age Group
Authors: Kim Myung-Gwan , Han Seungwoo 
Published: December 2020

Abstract
Background: The aim of this study was to identify factors that influence PTG in South Korean police officers, according to age group.Methods: Raw data were collected from September 26 to October 9, 2017 for 269 police officers who are employed at 10 police offices in Seoul. Multiple regression analysis was conducted on selected data by age group. Results: Post-traumatic growth (PTG) was affected significantly by age, marital status, monthly income, and police rank in pain perception and social support variables among general characteristics. Factors that affected PTG in the ‘20~29’ age group were resilience (B = 0.570) and pain perception (B = 0.243), but in the ‘30~39’ age group, only Pain perception (B = 0.249) was significant, and in the ‘over 50’ age group, social support (B = 0.448) and pain perception (B = 0.252) were significant.Conclusion: Development of mental health programs should consider the age group of the patients. Mental health care should also be continuous.
Can the Preoperative Prognostic Nutrition Index (PNI) Predict Surgical Site Infection Following Primary Total Knee Arthroplasty?
Authors: SHI JINGSHENG , YU JIE , DENG JINGDE , ZHENG CHAOJUN , ZHAO GUANGLEI , XIA JUN , WEI YIBIN , HUANG GANGYONG , WANG SIQUN , CHEN JIE 
Published: December 2020

Abstract
Background:Malnutrition is reported as one of the risk factors for surgical site infection (SSI). The prognostic nutritional index (PNI) is a simple method for nutritional evaluation. However, few studies have discussed the effectiveness of PNI as a nutritional assessment in predicting SSI after primary total knee arthroplasty (TKA). The aim of this study is to investigate the relationship between SSI and malnutrition as identified by the PNI scores following TKA. Methods: A retrospective analysis of 483 patients (SSI vs. non-SSI group: 19 vs. 464; follow-up period: at least 1 year) was performed to confirm the risk factors, including the PNI, associated with SSI after primary TKA using both univariate and multivariate analyses. Results: Postoperatively, nineteen patients (19/483, 3.9%) experienced SSI (deep vs. superficial SSI: 12 vs. 7), and periprosthetic joint infection was observed in all deep SSI cases. Univariate analysis showed that male sex, body weight, body mass index (BMI), diabetes mellitus, steroid usage, operative time and PNI differed between the SSI and non-SSI groups (P<0.05). Multivariate logistic regression analysis identified that the preoperative PNI (odds ratio [OR]: 0.859; 95% confidence interval [CI]: 0.762-0.969; cutoff [CV]: 49.27), operative time (OR: 1.005; 95% CI: 1.000-1.010; CV: 131.0 min), male sex (OR: 4.127; 95% CI: 1.165-14.615), diabetes mellitus (OR: 6.133; 95% CI: 2.067-18.193) and steroid usage (OR: 6.034; 95% CI: 1.521-23.935) were independently associated with SSI (P<0.05). Conclusions: A low preoperative PNI associated with malnutrition was demonstrated to be an independent risk factor for SSI following primary TKA. Patients with preoperative low PNI should be cautioned and provided with adequate nutritional intervention to reduce postoperative SSI.
Modelling the Transmission Dynamics of Severe Fever With Thrombocytopenia Syndrome in Jiangsu Province
Authors: Zhang Nan , Cheng Xiao-qing , Deng Bin , Rui Jia , Qiu Luxia , Zhao Zeyu , Lin Shengnan , Liu Xingchun , Xu Jingwen , Wang Yao , Yang Meng , Zhu Yuanzhao , Huang Jiefeng , Liu Chan , Liu Weikang , Luo Li , Li Zhuoyang , Li Peihua , Yang Tianlong , Li Zhi-feng , Liang Shu-yi , Wang Xiao-chen , Hu Jian-li , Chen Tianmu 
Published: December 2020

Abstract
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is regionally distributed in Asia with high fatality. Constructing the transmissibility model of SFTS could help provide clues for the intervention of disease control and fill the gap in the research of the SFTS model.Methods: Based on the Susceptible–Exposed–Infectious–Symptomatic–Recovered (SEIAR) model and combined with the epidemiological characteristics of SFTS in Jiangsu Province. An SFTS transmission dynamics model was built to evaluate the effect through cutting off the different transmission routes and taking different interventions, to offer clues for disease prevention and control, and filled the gap in research of the SFTS model. Results: For the transmission model of SFTS, the fitting effect of case data and model is great. Meanwhile, cutting off the transmission routes of the environment have the greatest effect on the prevention and control of SFTS, but isolation and shorten the course of the disease did not gain more effect.Conclusions: This study is determined that cutting off the transmission routes from the environment to humans had the greatest effect on SFTS prevention and control.