bluuebunny/crossref_metadata_2025_split huggingface dataset:
The possible attribution of abnormal lipid concentrations in Heart Failure: A comparative study.
Authors: Kumar Dr Rajendra , Kumar Dr Prodeep 
Published: September 2020

Objective : To find out the role of dyslipedemia as a contributing factor in heart failure cases and study comparatively with the Framingham study (meta analysis).
Methods : This was a cross- sectional study conducted in a tertiary care hospital. The study was approved by the ethics committee of the institute and consent was taken from each participant before enrolling in the study. A total of 100 cases with signs and symptoms of heart failure (Acute/Acute on Chronic and Chronic heart failure) were included in the study.
Background : The relationship of lipid concentrations to heart failure has been evaluated in a study derived from Framigham Heart study participants.
Contemplative Pedagogy in the College Classroom: Theory, Research, and Practice for Holistic Student Development
Authors: Faerm Steven 
Published: September 2020

experiencing emotional challenges. Students face an increasingly unstable and uncertain world due to rising political discord, terrorism, tensions between world powers, and more. Additional factors are further impacting college students’ emotional health. Research shows excessive engagement with digital technology –such as the high frequency of electronic messaging– negatively affects users’ sense of well-being. The extreme volumes of texts and tweets sent and received prevent people from feeling “unplugged” and present during any given situation; multitasking has become the normative behavior for professionals and students alike. Over time, these stresses weaken students’ cognitive, emotional, and physical health, and contribute to the record numbers of undergraduates seeking services for mental health issues.
In response, many U.S. colleges are adopting pedagogical techniques that target students’ mental health. Dubbed “Contemplative Pedagogy,” these simple yet highly effective methods aim to decrease stress levels, improve a sense of well-being, and increase “mindfulness” so that students feel more present in the classroom and beyond. By adopting these pedagogical methods, students’ emotional and cognitive development is strengthened. This paper aims to provide educators with an awareness of the rising emotional challenges experienced by college students today. This paper also provides educators with practical methods for incorporating contemplative pedagogy techniques into their classrooms for students’ academic and personal success.
Research on Highway Engineering Supervision and Project Management
Authors: Yang Wenyuan 
Published: September 2020

<p>As the main part of China's transportation, highway transportation has promoted China's economic development, and it has been concerned by the society for a long time. However, with the development of highway industry, the traffic volume and burden of highway are increasing day by day, and highway quality problems have appeared frequently, which undoubtedly poses a great threat to the economy and people's lives. Based on this, this paper mainly studies the engineering supervision and project management in highway engineering, and it provides corresponding suggestions.</p>
Study on the Application of Expressway Construction Based on Sponge City Concept
Authors: Chen Yuanzhi 
Published: September 2020

<p>Currently, in the active trial stage, sponge city concept has been applied in many low-impact development facilities on expressways in China, but many applications are not widely used. From four angles of pavement, slope, interchange and service area of expressway, this paper explains the adverse effects brought by rainwater, and then gives, and it carries out scene analysis combined with actual engineering projects with some feasible application schemes. Finally, the concept of sponge city at present is summarized, and it is considered that the optimal planning and design can be made only after establishing a reliable mathematical model and carrying out quantitative analysis.</p>
Research on the tourist traffic in protected areas in Romania
Authors: Anda Milin Ioana , Luliana Merce Ioana 
Published: September 2020

Ecotourism has been gaining popularity in recent times as more people are embracing the preservation of nature. Most countries are implementing laws to preserve natural habitats and other countries are practising a forestation in a bid to restore their lost nature. Romania is a country that is blessed with natural capital and is open to ecotourism. Over the years, Romania has been host to tourists from different countries, especially the European countries, who visit mostly to enjoy the eco tourist destinations of Romania. This research aimed to study the tourist traffic in protected areas in Romania and how they can be improved in order to generate further income for the Romanian tourism sector. This research made use of secondary data that were retrieved from the Association of Ecotourism Romania and the National Institute for Research and Development in Tourism. This research found out that most of the visitors to the Romanian tourist sites were the indigenes. However, tourists from different countries were more involved in ecotourism than the indigenes. At the end of this article, recommendations are made on how tourist traffic can be increased by the Romanian tourism department.

Keywords: Ecotourism, protected area, ecosystems, nature.
Impact of aggressive online digital marketing on sales in the Latin American and Caribbean regions
Authors: Pineida Felipe Oyarzo 
Published: September 2020

The aim of this research was to study how aggressive online digital marketing improves sales. The study was implemented across 27 countries, 15 countries in Latin America and 12 islands in the Caribbean regions, over a period of 2 years. Professional advertising images were shared monthly with 27 different distributors of a US textile company specialised in interior design. The showrooms were expected to promote their businesses via email and on Facebook, Pinterest, Instagram, WhatsApp, Twitter and through their own websites. Data were collected from the 27 participant firms with the help of interviews. The results of the study showed a strong connection between the use of professional digital advertisement and the growth of these businesses, while the showrooms that used little or no digital marketing strategies decreased or stayed low on profits. The study also showed that the quality and the content of the advertisement received by customers and how often they received it had an impact on their perception of the brand and the new products offered by the company. Data also showed that the most professional and attractive websites belonged to the most successful businesses. This research has also made recommendations to businesses and to future researchers at the end of the article.

Keywords: Corporate social responsibility, digital marketing, email, online marketing, social media.
LEGAL ASPECT OF ONLINE ARBITRATION IN EUROPEAN UNION AND CHINA
Authors: Sari Manja Indah 
Published: September 2020

<p>Indonesia is highly regarded as a country with the biggest e-commerce market in South-East Asia. This creates an urgency for the Indonesian government to offer an efficient and effective dispute resolution mechanism to settle dispute arising from e-commerce transaction. Online arbitration as an arbitration conducted online through means of internet and technology may provide solution to the disputes arising from e-commerce transactions. Thus, this article sets out the legal aspect of online arbitration in European Union and China as countries with the most developed online arbitration and largest market of e-commerce. The author will use normative research through comparative, statue approach and will be based on the regulations from primary and secondary resources.</p><p> This article compares six aspects of online arbitration in European Union and China, covering the arbiter, role of government, scope, procedure, enforcement, and factors affecting enforcement. The comparison may give further recommendation on the prospective of online arbitration in Indonesia.</p>
PERLINDUNGAN HUKUM DAN KEPASTIAN HUKUM TERHADAP ANAK ANGKAT YANG PROSES PENGANGKATANNYA MELALUI AKTA NOTARIS DI LUAR SISTEM PENGANGKATAN ANAK ANGKAT/ADOPSI YANG AKTANYA WAJIB DIBUAT DENGAN AKTA NOTARIS (STB.1917 NO 129)
Authors: Girsang Ruth Tria Enjelina 
Published: September 2020

Sumber Hukum Pengangkatan Anak di Indonesia adalah Staatsblad 1917 Nomor 129, di dalam Staatsblad 1917 nomor 129 dinyatakan bahwa pengangkatan anak melalui Notaris, kemudian setelah dikeluarkannya Peraturan Pemerintah Nomor 54 Tahun 2007 Tentang Pelaksanaan Pengangkatan Anak disebutkan bahwa pengangkatan anak menggunakan Putusan Pengadilan,terdapat penafsiran yang berbeda tentang kewenangan Notaris dalam membuat Akta Pengangkatan Anak. Masalah yang terjadi adalah Pengangkatan anak hanya dilakukan melalui Akta Notaris, tanpa dilanjutkan di Pengadilan. Berdasarkan tersebut penulis merumuskan masalah kewenangan Notaris dalam membuat Akta Pengangkatan Anak, Perlindungan Hukum dan Kepastian Hukum dari status akta pengangkatan anak yang dibuat oleh Notaris, dan apakah Akta tersebut sah atau tidak menurut Hukum. Hasil penelitian yang dilakukan penulis adalah Notaris mempunyai kewenangan dalam membuat Akta Pengangkatan Anak berdasarkan Staatsblad, namun setelah adanya Peraturan Pemerintah 54 tahun 2007 notaris memang tetap dibolehkan membuat Akta Pengangkatan Anak, namun akta tersebut hanya dapat dijadikan alat bukti untuk pengajuan di Pengadilan. Perlindungan Hukum preventif yang dilakukan adalah pengangkatan anak dilakukan dengan itikad baik dan melaksanakan sesuai dengan ketentuan yang berlaku, sedangkan Perlindungan Hukum Refresif mencegah adanya konflik terkait status akta yang dibuat sebelum adanya Peraturan Pemerintah 54 tahun 2007, akta tersebut tetap berlaku sepanjang tidak bertentangan dengan peraturan pemerintah tersebut. Akta Pengangkatan Anak yang dibuat oleh Notaris hanya sah sebagai perjanjian sesuai dengan ketentuan pasal 1320 KUHPerdata, namun akta tersebut tidak dapat memindahkan hak dan kewajiban orang tua kandung ke orang tua angkat, jika tidak dilakukan berdasarkan Putusan Pengadilan. Pengangkatan anak yang tidak dilakukan berdasarkan Putusan Pengadilan, dapat menyebabkan batal demi hukum.
The Effect of Herbicide Metribuzin on Environment and Human: A Systematic Review
Authors: Derouiche Samir  , Rezzag Mohcem Om Selma  , Serouti Asma  
Published: September 2020

Metribuzin is a synthetic organic compound used as a selective Triazinone herbicide, incorporated as a post-emergent soil applied herbicide to control weeds in wheat, potato, tomato and others. The aim of this study was to assess the impact of Metribuzin on the environment and human health. Human exposure to Metribuzin occurs through inhalation and ingestion, usually in agricultural settings. Farmers' occupational exposure to Metribuzin is highly variable and complex depending on the farm but Few studies have assessed the exposure of the population to this herbicide. Metribuzin can accumulate in soil and water and cause damage to flora and fauna. furthermore, Herbicides Metribuzin have a very variable toxicity, in the short term it can cause acute intoxication which can cause breathing and difficult drowsiness but the high exposures can cause stomach aches, fatigue and depression of the central nervous system, on the other hand in the long term and with strong exposure or other repeated it can cause modifications of the hepatic enzymes, disturbance in the kidneys, can affect the reproduction, the endocrine function and oxidant/antioxidant system imbalance. This study highlights on the undesirable effect of Metribuzin which allows to affirm their toxicity even at low doses, is not only following an occupational exposure, but also for the general population by their use of treated agricultural products by these pesticides, which poses a real public health problem. Accordingly, it is imperative that farmers avoid their use and replace them with biological fertilizers that are less harmful to human and animal health.
Burden of viral hepatitis caused by specific aetiologies in China, 1990-2016: findings from the GBD 2016
Authors: Li Man , Wang Zhuo-qun , Zhang Lu , Zheng Hao , Zhou Mai-geng , Liu Dian-wu 
Published: September 2020

Abstract
Purpose The aim of this study is to quantify the burden caused by viral hepatitis in China from 1990 to 2016. Methods: Data from the GBD 2016 study were extracted to calculate incidence, prevalence and disability-adjusted life years (DALYs). Trends in DALYs were assessed in 33 provinces/regions. Results: From 1990 to 2016, the total incidence of hepatitis decreased by 88.5%. However, the prevalence of hepatitis (counts in thousands), increased by 37.6% from 153,856 (95% UI: 136,047-172,319) in 1990 to 211,721 (95% UI: 179,776-240,981) in 2016, with age-standardized prevalence rates changing slightly. The number and age-standardized rates of prevalence increased by 35.9% and 1.6% for hepatitis B, respectively, and by 81.8% and 30.4% for hepatitis C. Guangxi, Guangdong and Hainan had the highest age-standardized prevalence rates (≥16,500 per 100,000). Tibet, Qinghai and Gansu had the highest age-standardized DALYs rates (≥40 per 100,000). The largest absolute number of DALYs was observed in the 15-49 year age group in 2016. The highest rate of DALYs occurred in males aged 50-69 years and in females aged ≧70 years. Conclusion: The incidence and DALYs of viral hepatitis decreased dramatically from 1990 to 2016. However, the prevalence still remains at a high level, which may result in heavy burdens in the future.
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Authors: Lampi Elina , Carlsson Fredrik , Sundvall Pär-Daniel , Torres Marcela Jaime , Ulleryd Peter , Åhrén Christina , Jacobsson Gunnar 
Published: September 2020

Abstract
Background: Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in reducing antibiotic prescription rates. This study investigates whether two specific interventions directed toward healthcare centers, an informational visit and a self-evaluation meeting, played a role in observed reduction in rates of antibiotic prescriptions in primary healthcare. Methods: The study was a retrospective, observational, empirical analysis exploiting the variation in the timing of the interventions and considering past prescriptions through use of estimations from dynamic panel data models. Primary healthcare data from 2011 to 2014 were examined. Data were from public and private primary healthcare centers in western Sweden. The key variables were prescription of antibiotics and indicator variables for the two interventions. Results: The first intervention, an educational information intervention, decreased the number of prescriptions among public healthcare centers, but this effect was only temporary. We found no proof that the second intervention, a self-evaluation meeting at the healthcare center, had an impact on the reduction of prescriptions. Conclusions: Single educational interventions aimed at influencing rates of antibiotic prescriptions have limited impact. A multifaceted approach is needed in efforts to reduce the use of antibiotics in primary health care.
Exploring contraception myths and misconceptions among young men and women in Kwale County, Kenya
Authors: Mwaisaka Jefferson , Gonsalves Lianne , Thiongo Mary , Waithaka Michael , Sidha Hellen , Agwanda Alfred , Mukiira Carol , Gichangi Peter 
Published: September 2020

Abstract
Background
Myths and misconceptions around modern contraceptives have been associated with low contraceptive uptake in sub-Saharan Africa and Kenya in particular. Addressing persistent contraceptive knowledge gaps can make a significant contribution towards improved contraceptive uptake among young women. This qualitative study therefore sought to explore and understand young people’s knowledge of modern contraception and to identify their key concerns regarding these methods.

Methods
We used focus group discussions (FGD) with vignette and writing activities to explore key myths and misconceptions around the use of contraceptives. Six FGDs (three for young men and three for young women) were conducted with a total of 28 young women and 30 young men from Kwale County, Kenya. We included 10 discussants aged 18-24 per FGD, one FGD had 8 participants. Predefined codes reflecting the discussion guides and emerging issues in the FGDs were used to develop the thematic coding framework. Our analysis followed a pattern of association on the key preset themes focusing on myths and misconceptions around contraceptive use.

Results
Results are presented under three key themes: awareness of contraception, myths and misconceptions around contraception, and males’ contraceptive narratives. Both men and women participants reported basic awareness of contraceptives. A mixture of biological and social misconceptions were discussed and included perceptions that modern contraception: jeopardized future fertility, prolonged menstrual bleeding, could result in problems conceiving or birth defects, made women promiscuous, was ‘un-African’, and would deny couples their sexual freedom. Compared to female respondents, young men appeared to be strong believers of the perceived socio-cultural effects of contraceptives.

Conclusions
This study revealed the presence of a mixture of biological and social myths and misconceptions around contraception, with young men also strongly adhering to these misconceptions. The low level of contraceptive knowledge, particularly on contraceptive fears as revealed by the study demonstrate critical gaps in sexual and reproductive health (SRH) knowledge among young people. Improved SRH literacy to address contraceptives’ fears through appropriate and gender specific interventions to reach out to young men and women with factual SRH information may therefore contribute to increased uptake of SRH services including modern contraceptive methods.
What makes advocacy work? Stakeholders’ voices and insights from prioritisation of Maternal and Child Health programme in Nigeria
Authors: Uzochukwu Benjamin , Onyedinma Chioma , Okeke Chinyere , Onwujekwe Obinna , Manzano Ana , Ebenso Bassey , Etiaba Enyi , Ezumah Nkoli , Mirzoev Tolib 
Published: September 2020

Abstract
Background: The Nigerian government introduced and implemented a health programme to improve maternal and child health (MCH) called Subsidy Reinvestment and Empowerment programme for MCH (SURE-P/MCH). It ran from 2012 and ended abruptly in 2015 and was followed by increased advocacy for sustaining the MCH (antenatal, delivery, postnatal and immunization) services as a policy priority. Advocacy is important in allowing social voice, facilitating prioritization, and bringing different forces/actors together. Therefore, the study set out to understand how advocacy works - through understanding what effective advocacy implementation processes comprise and what mechanisms are triggered by which contexts to produce the intended outcomes. Methods: The study used a Realist Evaluation design through a mixed quantitative and qualitative methods case study approach. The programme theory (PT) was developed from three substantive social theories (power politics, media influence communication theory, and the three-streams theory of agenda-setting), data and programme design documentation, and subsequently tested. We report information from 22 key informant interviews including national and State policy and law makers, policy implementers, CSOs, Development partners, NGOs, health professional groups, and media practitioners and review of relevant documents on advocacy events post-SURE-P. Results: Key advocacy organizations and individuals including health professional groups, the media, civil society organizations, powerful individuals, and policymakers were involved in advocacy activities. The nature of their engagement included organizing workshops, symposiums, town hall meetings, individual meetings, press conferences, demonstrations, and engagements with media. Effective advocacy mechanism involved alliance brokering to increase influence, the media supporting and engaging in advocacy, and the use of champions, influencers, and spouses (Leadership and Elite Gendered Power Dynamics). The key contextual influences which determined the effectiveness of advocacy measures for MCH included the political cycle, availability of evidence on the issue, networking with powerful and interested champions, and alliance building in advocacy. All these enhanced the entrenchment of MCH on the political and financial agenda at the State and Federal levels. Conclusions: Our result suggest that advocacy can be a useful tool to bring together different forces by allowing expression of voices and ensuring accountability of different actors including policymakers. In the context of poor health outcomes, interest from policymakers and politicians in MCH, combined with advocacy from key policy actors armed with evidence, can improve prioritization and sustained implementation of MCH services.
Bone morphogenetic protein (BMP) receptor inhibitor JL5 synergizes with Ym155 to induce Apoptosis-Inducing Factor (AIF) caspase independent cell death
Authors: Mondal Arindam , NeMoyer Rachel , Langenfeld Elaine , Glover Danea , Scott Michael , Lairson Lauren , Zloza Andrew , Augeri David , Gilleran John , Peng Youyi , Roberge Jacques , Langenfeld John E. 
Published: September 2020

Abstract
Background: Bone morphogenetic protein (BMP) is an evolutionarily conserved morphogen that is reactivated in lung carcinomas. BMP receptor inhibitors promote cell death of lung carcinomas by mechanisms not fully elucidated. The studies here reveal novel mechanisms by which the “survivin” inhibitor Ym155 in combination with the BMP receptor inhibitor JL5 synergistically induces death of lung cancer cells.Methods: This study examines the mechanism by which Ym155 in combination with JL5 downregulates BMP signaling and induces cell death of non-small cell lung carcinoma (NSCLC) cell lines. Validation experiments were performed on five passage 0 primary NSCLC cell lines.Results: We found that Ym155, which is reported to be a survivin inhibitor, potently inhibits BMP signaling by causing BMPR2 mislocalization into the cytoplasm and its decreased expression. The combination of Ym155 and the BMP receptor inhibitor JL5 synergistically causes the downregulation of BMP Smad-1/5 dependent and independent signaling and the induction of cell death of lung cancer cell lines and primary lung tumors. Cell death involves the nuclear translocation of apoptosis inducing factor (AIF) from the mitochondria to the nucleus. This causes DNA double stranded breaks independent of caspase activation, which occur only when JL5 and Ym155 are used in combination. Knockdown of BMPR2 together with Ym155 also induced AIF localization to the nucleus.Conclusions: These studies suggest that inhibition of BMPR2 together with Ym155 can induce AIF caspase-independent cell death. AIF caspase-independent cell is an evolutionarily conserved cell death pathway that has never been targeted to induce cell death in cancer cells. These studies provide mechanistic insight of how to target AIF caspase-independent cell death using BMP inhibitors.