bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of magnetic field in a weakly relativistic counterstreaming inhomogeneous e−/e+ plasmas
Authors: Kumar Sandeep , Kim Y. K. , Kang T. , Hur Min Sup , Chung Moses 
Published: July 2020

AbstractThe nonlinear evolution of electron Weibel instability in a symmetric, counterstream, unmagnetized electron–positron e−/e+ plasmas is studied by a 2D particle-in-cell (PIC) method. The magnetic field is produced and amplified by the Weibel instability, which extracts energy from the plasma anisotropy. A weakly relativistic drift velocity of 0.5c is considered for two counterstreaming e−/e+ plasma flows. Simulations show that in a homogeneous e−/e+ plasma distribution, the magnetic field amplifies exponentially in the linear regime and rapidly decays after saturation. However, in the case of inhomogeneous e−/e+ plasma distribution, the magnetic field re-amplifies at post-saturation. We also find that the amount of magnetic field amplification at post-saturation depends on the strength of the density inhomogeneity of the upstream plasma distribution. The temperature calculation shows that the finite thermal anisotropy exists in the case of an inhomogeneous plasma distribution which leads to the second-stage magnetic field amplification after the first saturation. Such density inhomogeneities are present in a variety of astrophysical sources: for example, in supernova remnants and gamma-ray bursts. Therefore, the present analysis is very useful in understanding these astrophysical sources, where anisotropic density fluctuations are very common in the downstream region of the relativistic shocks and the widely distributed magnetic field.
Futility in the paediatric cardiac ICU
Authors: Fundora Michael P. , Rodriguez Zahidee , Mahle William T. 
Published: July 2020

AbstractIntroduction:Studies have suggested 5–20% of paediatric ICU patients may receive care felt to be futile. No data exists on the prevalence and impact of futile care in the Paediatric Cardiac ICU. The aim is to determine the prevalence and economic impact of futile care.Materials and method:Retrospective cohort of patients with congenital cardiac disease 0–21 years old, with length of stay >30 days and died (2015–2018). Documentation of futility by the medical team was retrospectively and independently reviewed.Results:Of the 127 deaths during the study period, 51 (40%) had hospitalisation >30 days, 13 (25%) had received futile care and 26 (51%) withdrew life-sustaining treatment. Futile care comprised 0.69% of total patient days with no difference in charges from patients not receiving futile care. There was no difference in insurance, single motherhood, education, income, poverty, or unemployment in families continuing futile care or electing withdrawal of life-sustaining treatment. Black families were less likely than White families to elect for withdrawal (p = 0.01), and Hispanic families were more likely to continue futile care than non-Hispanics (p = 0.044).Conclusions:This is the first study to examine the impact of futile care and characteristics in the paediatric cardiac ICU. Black families were less likely to elect for withdrawal, while Hispanic families more likely to continue futile care. Futile care comprised 0.69% of bed days and little burden on resources. Cultural factors should be investigated to better support families through end-of-life decisions.
Prevalence and predictors of hypocalcaemia in severe acute malnutrition
Authors: Smilie Chabungbam , Shah Dheeraj , Batra Prerna , Ahmed Rafat S , Gupta Piyush 
Published: July 2020

AbstractObjective:To determine the prevalence and predictors of hypocalcaemia in under-five children (1–59 months) hospitalised with severe acute malnutrition (SAM).Design:A cross-sectional study was designed to determine the prevalence of hypocalcaemia among children hospitalised with SAM. Serum Ca and 25-hydroxycholecalciferol (25-(OH)D) were estimated. Hypocalcaemia was defined as serum Ca (albumin-adjusted) <2·12 mmol/l. To identify the clinical predictors of hypocalcaemia, a logistic regression model was constructed taking hypocalcaemia as a dependent variable, and sociodemographic and clinical variables as independent variables.Setting:A tertiary care hospital in Delhi, between November 2017 and April 2019.Participants:One-hundred and fifty children (1–59 months) hospitalised with SAM were enrolled.Results:Hypocalcaemia was documented in thirty-nine (26 %) children hospitalised with SAM, the prevalence being comparable between children aged <6 months (11/41, 26·8 %) and those between 6 and 59 months (28/109, 25·7 %) (P = 0·887). Vitamin D deficiency (serum 25-(OH)D <30 nmol/l) and clinical rickets were observed in ninety-eight (65·3 %) and sixty-three (42 %) children, respectively. Hypocalcaemia occurred more frequently in severely malnourished children with clinical rickets (OR 6·6, 95 % CI 2·54, 17·15, P < 0·001), abdominal distension (OR 4·5, 95 % CI 1·39, 14·54, P = 0·012) and sepsis (OR 2·6, 95 % CI 1·00, 6·57, P = 0·050).Conclusion:Rickets and hypocalcaemia are common in children with SAM. Routine supplementation of vitamin D should be considered for severely malnourished children. Ca may be empirically prescribed to severely malnourished children with clinical rickets, abdominal distension and/or sepsis.
2-LOCAL DERIVATIONS ON SEMISIMPLE BANACH ALGEBRAS WITH MINIMAL LEFT IDEALS
Authors: HUANG WENBO , LI JIANKUI 
Published: July 2020

AbstractLet${\mathcal{A}}$be a semisimple Banach algebra with minimal left ideals and$\text{soc}({\mathcal{A}})$be the socle of${\mathcal{A}}$. We prove that if$\text{soc}({\mathcal{A}})$is an essential ideal of${\mathcal{A}}$, then every 2-local derivation on${\mathcal{A}}$is a derivation. As applications of this result, we can easily show that every 2-local derivation on some algebras, such as semisimple modular annihilator Banach algebras, strongly double triangle subspace lattice algebras and${\mathcal{J}}$-subspace lattice algebras, is a derivation.
‘Felt security’ as a means of facilitating imagery rescripting in psychosis: a clinical protocol and illustrative case study
Authors: Newman-Taylor Katherine 
Published: July 2020

Abstract
People with psychosis do not have routine access to trauma-focused cognitive behavioural therapy (CBT) interventions such as imagery rescripting (IR), partly due to clinical caution. This case study describes the use of a simple imagery task designed to engender ‘felt security’, as a means of facilitating IR with a woman struggling with distressing memory intrusions, linked to her voices and paranoia. We assessed the impact of the felt security task, which was used before IR to enable Kip to engage in reprocessing of her trauma memories, and again after IR so that she would leave sessions feeling safe. The brief imagery task was effective in improving felt security before IR sessions. Felt security then reduced during IR, when distressing material was recalled and reprocessed, and increased again when the task was repeated. It is not yet clear whether trauma-focused interventions such as IR need to be routinely adapted for people with psychosis. In the event that individuals express concerns about IR, if the person’s formulation indicates that high levels of arousal may trigger an exacerbation of voices, paranoia or risk, or where clinicians are otherwise concerned about interventions likely to increase emotional arousal in the short term, the felt security task may facilitate safe and effective reprocessing of trauma memories. This in turn may increase access to trauma-focused CBT for people with psychosis.

Key learning aims

(1)
To understand that people with psychosis need access to trauma-focused CBT.

(2)
To be familiar with a simple attachment-based imagery task designed to foster ‘felt security’.

(3)
To learn that this task may facilitate imagery rescripting in people with psychosis.
A novel approach of high-resolution UWB microwave imaging system based on an improved 3D back-projection method for early-stage breast cancer detection applications
Authors: Mehranpour M. , Jarchi S. , Ghorbani A. , Keshtkar A. 
Published: July 2020

AbstractIn this paper, a novel approach of high-accuracy calibration (HAC) method is employed to improve the resolution of tumor detection within a fibro-glandular breast model, and also an improved 3D back-projection approach to scan each focal point inside of the breast is presented. For these purposes, a simulated hemispherical setup of a multi-static array with a modified UWB bowtie antenna is applied around the breast. The superiority of the proposed HAC method is that all-time delays of multi-static channel paths are taken into account at preprocessing of reflected signals, and therefore the time location of tumor response can be estimated accurately in the late stage of recorded signals. As a result, stronger signals are obtained to detect the location of the tumor with higher spatial accuracy. By using the improved 3D back-projection method, a better approximation of transmission channel paths based on Fermat's principle is achieved. A realistic breast model is proposed with two cases of single and twin spherical tumors. Then, to validate the efficiency of the proposed HAC method to detect the time-dependent tumor location, several scenarios are studied in the mentioned model. Quantitative metrics of successfully reconstructed tumor (with a small radius of 7 mm) images prove the ability of the proposed imaging method for early-stage breast cancer detection.
The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude
Authors: Gonzaléz-Candia Alejandro , Candia Alejandro A. , Ebensperger Germán , Reyes Roberto V. , Llanos Aníbal J. , Herrera Emilio A. 
Published: July 2020

AbstractChronic hypoxia during gestation induces greater occurrence of perinatal complications such as intrauterine growth restriction, fetal hypoxia, newborn asphyxia, and respiratory distress, among others. This condition may also cause a failure in the transition of the fetal to neonatal circulation, inducing pulmonary arterial hypertension of the neonate (PAHN), a syndrome that involves pulmonary vascular dysfunction, increased vasoconstrictor tone and pathological remodeling. As this syndrome has a relatively low prevalence in lowlands (~7 per 1000 live births) and very little is known about its prevalence and clinical evolution in highlands (above 2500 meters), our understanding is very limited. Therefore, studies on appropriate animal models have been crucial to comprehend the mechanisms underlying this pathology. Considering the strengths and weaknesses of any animal model of human disease is fundamental to achieve an effective and meaningful translation to clinical practice. The sheep model has been used to study the normal and abnormal cardiovascular development of the fetus and the neonate for almost a century. The aim of this review is to highlight the advances in our knowledge on the programming of cardiopulmonary function with the use of high-altitude newborn sheep as a translational model of PAHN.
The Dual Isotopic Composition of Nitrate in the Gulf of Mexico and Florida Straits
Authors: Howe Samantha , Miranda Carlos , Hayes Christopher T. , Letscher Robert T. , Knapp Angela N. 
Published: July 2020

AbstractThe Gulf of Mexico receives considerable riverine nutrient inputs that contribute to eutrophication of northern shelf waters. However, it is unclear whether a significant fraction of these riverine nutrients delivered to the Gulf of Mexico are subsequently exported from the Gulf, potentially influencing the chemistry of the North Atlantic. Here, we report the first dual isotopic composition (“δ15N” and “δ18O”) measurements of nitrate (NO3−) from three profiles collected in different years in the Gulf of Mexico, as well as a new profile from the Florida Straits. We compare these new measurements with prior measurements from the North and South Atlantic, as well as with the magnitude of riverine and other nitrogen fluxes to the Gulf of Mexico. We find that in the upper thermocline, NO3− δ15N measurements from the Gulf of Mexico are intermediate between prior measurements in the Sargasso Sea (lower in NO3− δ15N), and those from the South Atlantic (higher in NO3− δ15N), but are indistinguishable from Florida Straits and Sargasso Sea profiles on deeper isopycnal surfaces. There is little evidence for riverine NO3− influencing the isotopic composition of NO3− exported from the Gulf of Mexico, which, based on its δ15N, would be expected to raise the δ15N of shallow NO3−. Lesser nitrogen fluxes are too small to significantly influence the isotopic composition of water column NO3− in the Gulf of Mexico. These results are consistent with recent modeling work suggesting that the majority of riverine nutrients are retained in the nearshore region.
The Impact of Wettability and Surface Roughness on Fluid Displacement and Capillary Trapping in 2‐D and 3‐D Porous Media: 2. Combined Effect of Wettability, Surface Roughness, and Pore Space Structure on Trapping Efficiency in Sand Packs and Micromodels
Authors: Zulfiqar Bilal , Vogel Hannes , Ding Yi , Golmohammadi Saeed , Küchler Matthias , Reuter Danny , Geistlinger Helmut 
Published: July 2020

AbstractA comprehensive understanding of the combined effects of surface roughness and wettability on the dynamics of the trapping process is lacking. This can be primarily attributed to the contradictory experimental and numerical results regarding the impact of wettability on the capillary trapping efficiency. The discrepancy is presumably caused by the surface roughness of the inner pore‐solid interface. Herein, we present a comparative μ‐CT study of the static fluid‐fluid pattern in porous media with smooth (glass beads) and rough surfaces (natural sands). For the first time, a global optimization method was applied to map the characteristic geometrical and morphological properties of natural sands to 2‐D micromodels that exhibit different degrees of surface roughness. A realistic wetting model that describes the apparent contact angle of the rough surface as a function surface morphology and the intrinsic contact angle was also proposed. The dynamics of the trapping processes were studied via visualization micromodel experiments. Our results revealed that sand and glass beads displayed opposite trends in terms of the contact angle dependence between 5° and 115°. Sand depicted a nonmonotonous functional contact angle dependency, that is, a transition from maximal trapping to no trapping, followed by an increase to medium trapping. In contrast, glass beads showed a sharp transition from no trapping to maximal trapping. Since both porous media exhibit similar morphological properties (similar Minkowski functions: porosity, surface density, mean curvature density, Euler number density), we deduce that this difference in behavior is caused by the difference in surface roughness that allows complete wetting and hence precursor thick‐film flow for natural sands. Experimental results on micromodels verified this hypothesis.
Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells
Authors: Caillot M. , Bourgeais J. , Dakik H. , Costé É. , Mazure N. M. , Lelièvre É. , Coqueret O. , Hérault O. , Mazurier F. , Sola B. 
Published: July 2020

AbstractCancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role of cyclin D1 in promoting this effect in a cyclin-dependent kinase (CDK)4/6-independent manner in multiple myeloma (MM) cells. We show that the cyclin D1 oncoprotein targets hexokinase 2 (HK2), a major glycolysis regulator, through two original molecular mechanisms in the cytoplasmic and nuclear compartments. In the cytoplasm, cyclin D1 binds HK2 at the outer mitochondrial membrane, and in the nucleus, it binds hypoxia-inducible factor-1α (HIF1α), which regulates HK2 gene transcription. We also show that high levels of HK2 expression are correlated with shorter event-free survival (EFS) and overall survival (OS) in MM patients. HK2 may therefore be considered as a possible target for antimyeloma therapy.
Understanding rat emotional responses to CO2
Authors: Améndola Lucía , Weary Daniel. M. 
Published: July 2020

AbstractThe aim of this review is to summarize evidence regarding rat emotional experiences during carbon dioxide (CO2) exposure. The studies reviewed show that CO2exposure is aversive to rats, and that rats respond to CO2exposure with active and passive defense behaviors. Plasma corticosterone and bradycardia increased in rats exposed to CO2. As with anxiogenic drugs, responses to CO2are counteracted by the administration of anxiolytics, SRIs, and SSRI’s. Human studies reviewed indicate that, when inhaling CO2, humans experience feelings of anxiety fear and panic, and that administration of benzodiazepines, serotonin precursors, and SSRIs ameliorate these feelings. In vivo and in vitro rat studies reviewed show that brain regions, ion channels, and neurotransmitters involved in negative emotional responses are activated by hypercapnia and acidosis associated with CO2exposure. On the basis of the behavioral, physiological, and neurobiological evidence reviewed, we conclude that CO2elicits negative emotions in rats.
Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance
Authors: Sun Jie , Yan Wei , Zhang Xing-Nan , Lin Xiao , Li Hui , Gong Yi-Miao , Zhu Xi-Mei , Zheng Yong-Bo , Guo Xiang-Yang , Ma Yun-Dong , Liu Zeng-Yi , Liu Lin , Gao Jia-Hong , Vitiello Michael V. , Chang Su-Hua , Liu Xiao-Guang , Lu Lin 
Published: July 2020

AbstractChronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interplay between sleep disturbance and chronic pain is likely to lead to better treatment. In this study, we combined 1206 participants with phenotype data, resting-state functional magnetic resonance imaging (rfMRI) data and genotype data from the Human Connectome Project and two large sample size genome-wide association studies (GWASs) summary data from published studies to identify the genetic and neural bases for the association between pain and sleep disturbance. Pittsburgh sleep quality index (PSQI) score was used for sleep disturbance, pain intensity was measured by Pain Intensity Survey. The result showed chronic pain was significantly correlated with sleep disturbance (r = 0.171, p-value < 0.001). Their genetic correlation was rg = 0.598 using linkage disequilibrium (LD) score regression analysis. Polygenic score (PGS) association analysis showed PGS of chronic pain was significantly associated with sleep and vice versa. Nine shared functional connectivity (FCs) were identified involving prefrontal cortex, temporal cortex, precentral/postcentral cortex, anterior cingulate cortex, fusiform gyrus and hippocampus. All these FCs mediated the effect of sleep disturbance on pain and seven FCs mediated the effect of pain on sleep disturbance. The chronic pain PGS was positively associated with the FC between middle temporal gyrus and hippocampus, which further mediated the effect of chronic pain PGS on PSQI score. Mendelian randomization analysis implied a possible causal relationship from chronic pain to sleep disturbance was stronger than that of sleep disturbance to chronic pain. The results provided genetic and neural evidence for the association between pain and sleep disturbance, which may inform future treatment approaches for comorbid chronic pain states and sleep disturbance.
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma
Authors: Zheng Shengnai , Wan Li , Ge Dawei , Jiang Fan , Qian Zhanyang , Tang Jian , Yang Jin , Yao Yilun , Yan Junwei , Zhao Lei , Li Haijun , Yang Lei 
Published: July 2020

AbstractOsteosarcoma (OS) is one of the most common primary bone malignancies and accounts for 3.4% of pediatric tumors. Its 5-year survival is as low as about 20%. Differentially expressed lncRNAs in OS profiling were searched in the downloaded profile of GSE12865. As a result, LINC00266-1 was detected to be upregulated in both GSE12865 and OS tissues we collected. SMAD2 was the downstream target binding to promoter sites of LINC00266-1, displaying a positive regulatory interaction. Knockdown of LINC00266-1 suppressed the proliferative and metastatic abilities, and promoted the apoptosis in OS cells. Besides, knockdown of LINC00266-1 significantly alleviated the growth of OS in vivo. MiR-548c-3p was the sponge miRNA of LINC00266-1, which was able to reverse the regulatory effects of LINC00266-1 on OS cell phenotypes. Moreover, miR-548c-3p bound to the 3′-UTR of SMAD2 and thus downregulated SMAD2. Overexpression of SMAD2 partially reversed the regulatory effects of LINC00266-1 on OS cell phenotypes. Finally, we have identified that LINC00266-1/miR-548c-3p/SMAD2 feedback loop was responsible for stimulating the development of OS.
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions
Authors: Deseke Malte , Prinz Immo 
Published: July 2020

AbstractT lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs are triggered by specific peptides presented in the context of MHC was elucidated some time ago. In contrast, the mechanisms that underlie antigen recognition by γδ TCRs are still baffling the scientific community. It is clear that activation of γδ TCRs does not necessarily depend on MHC antigen presentation. To date, diverse and largely host-cell-derived molecules have been identified as cognate antigens for the γδ TCR. However, for most γδ TCRs, the activating ligand is still unknown and many open questions with regard to physiological relevance and generalizable concepts remain. Especially the question of how γδ T cells can distinguish homeostatic from stress conditions via their TCR remains largely unresolved. Recent discoveries in the field might have paved the way towards a better understanding of antigen recognition by the γδ TCR and have made it conceivable to revise the current knowledge and contextualize the new findings.
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
Authors: Toubal Amine , Kiaf Badr , Beaudoin Lucie , Cagninacci Lucie , Rhimi Moez , Fruchet Blandine , da Silva Jennifer , Corbett Alexandra J. , Simoni Yannick , Lantz Olivier , Rossjohn Jamie , McCluskey James , Lesnik Philippe , Maguin Emmanuelle , Lehuen Agnès 
Published: July 2020

AbstractObesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis is a consequence as well as a driver of obesity and diabetes. Mucosal-associated invariant T cells (MAIT) are innate-like T cells expressing a semi-invariant T cell receptor restricted to the non-classical MHC class I molecule MR1 presenting bacterial ligands. Here we show that during obesity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance and impaired glucose and lipid metabolism. MAIT cells act in adipose tissue by inducing M1 macrophage polarization in an MR1-dependent manner and in the gut by inducing microbiota dysbiosis and loss of gut integrity. Both MAIT cell-induced tissue alterations contribute to metabolic dysfunction. Treatment with MAIT cell inhibitory ligand demonstrates its potential as a strategy against inflammation, dysbiosis and metabolic disorders.