bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Topical Toman Fish (Channa micropeltes) Extract on Macrophages and Lymphocytes in Diabetes Mellitus Wound Healing
Authors: Carabelly A N , Firdaus I W A K , Nurmardina P C , Putri D A , Apriasari M L 
Published: November 2019

AbstractOral administration of Toman fish extract is proven to accelerate wound healing in rat model of Diabetes Mellitus. Toman fish extract contains albumin which may elevate antioxidant level and reduce inflammation. These changes will later enhance cell proliferation and inflammatory cell activity in wound healing process. This study was aimed to determine the topical application effect of 20% toman fish extract on macrophages and lymphocytes in Diabetes Mellitus wound healing. It was an experimental research using post-test only with control group design. This study was performed on 36 diabetic male wistar rats which was comprised of negative control group without given any treatment, 20% Toman fish extract ointment group and 10% Haruan fish (Channa striata) extract ointment group. Rats were sacrificed on day 4, 8, and 14 to investigate wounded area with biopsy technique which later obtained histological preparation using Haematoxylin-Eosin staining. The preparation was then observed using microscope to count macrophages and lymphocytes number. One-Way ANOVA test demonstrated a significant difference in macrophage number on day 4 (p=0.002), day 8 (p=0.000), day 14 (p=0.000). The result of the test also indicated a significant difference in lymphocyte number on day 4 (p=0.001), day 8 (p=0.001), and day 14 (p=0.001). Furthermore, Post Hoc LSD test resulted in a significant difference (p<0.05) of macrophage and lymphocyte in day four, eight, and fourteen among all treatment groups. Toman fish extract ointment at 20% concentration for topical application may raise the number of macrophage and lymphocyte than those of negative control and 10% haruan fish extract ointment on day 4 and 8 with gradual decrease on day 14.
The preventive effect of activated charcoal on HDL levels and aorta histopathological profiles in hypercholesterol rat models
Authors: Roosdiana A , Vidiastuti D , Herenda H 
Published: November 2019

Abstract
Hypercholesterolemia is a condition which the cholesterol levels in the blood exceeds the normal value. The use of hypercholesterolemia drugs or synthetic drugs in a long term will cause severe side effects. Therefore, it is important to explore an alternative preventive agent of hypercholesterolemia derived from natural materials, such as activated charcoal. The activated charcoal can absorb substances thousands times of its own weight and might be an effective and non-toxic material. The research aimed to determine the preventive effect of activated charcoal towards HDL level and aorta’s histopathology. This experiment used 24 male rats in randomized design that were divided into six groups: negative control (1); positive control (2), and four groups of treatments with activated charcoal doses of 2.250 mg/kg BW (3), 4.950 mg/kg BW (4), 6.750 mg/kg BW (5) 4.950 mg/kg BW (6), respectively, for 14 days. Simultaneously, all groups were received high cholesterol diet except group 1 and group 6. High Density Lipoprotein (HDL) level was measured by the spectrophotometry method and the data of HDL were analyzed using One-Way ANOVA and followed by the Tukey test (p<0.05), while aorta’s histopathology were analyzed descriptively. Therapeutic dose of 4.950 mg/kg BW (group 4) showed the best dose in increasing HDL levels by 42% compared to positive control. Activated charcoal reduced the inflammation cells and the defect of aorta’s histopathology. Based on the results, activated charcoal prevents the decreasing of HDL level and a defect of aorta’s histopathology.
Effect of fat supplementation containing high palmitic acid enriched with lecithin on quail performances
Authors: Syarif I , Hermana W , Retnani Y 
Published: November 2019

Abstract
The aim of this study was to observe the effect of fat supplementation containing high palmitic acid enriched with lecithin on the performances of quail starter-grower phase. This study used a completely randomized design with 330 female day old quails Coturnix Coturnix Japonica randomized and entered into 5 treatments consisted of commercial feed (T0), T0 + 2.5% fat local + 6% lecithin from added fat (T1), T0 + 2.5% fat commercial + 6% lecithin from added fat (T2), T0 + 5% fat local + 6% lecithin from added fat (T3), T0 + 5% fat commercial + 6% lecithin from added fat (T4). The results showed that fat supplementation containing high palmitic acid enriched with lecithin was not significantly different (P<0.05) on body weight, daily body weight gain at the age of 36-42 days, feed consumption, feed conversion ratio, and mortality but daily body weight gain was significantly different (P<0.05) at the age of 8-35 days. Local fat supplementation containing high palmitic acid produced a higher income over feed cost than the control treatment and fat commercial treatment. Fat supplementation containing high palmitic acid enriched with lecithin did not interfere with quail health status as a whole.
Dihydroeponemycin inhibits ubiquitin proteasome system of Plasmodium falciparum in silico
Authors: Mardhiyyah K , Arif M H , Fitri L E , Winarsih S , Chandradikusuma D , Nurseta T 
Published: November 2019

Abstract
Drug resistance in malaria treatment becomes major problems all over the world. Finding a novel potent antimalarial candidate is mandatory. Previous study proved that secondary metabolite of Streptomyces hygroscopicus Hygroscopicus containing eponemycin analog significantly inhibits Ubiquitin Proteasome System (UPS) of Plasmodium in vivo. The aims of this study are to know toxicity profile of dihydroeponemycin and its potency as Ubiquitin Proteasome System inhibitor of Plasmodium falciparum. The methods of this study were ADMET SAR Toxicity (ACD/LABS), Protein Modelling (SWISS), and Molecular Docking (AUTODOCK VINA PYRX). The result of Absorption, Distribution, Metabolism, Excretion and Toxicity profiles (ADMET) of dihydroeponemycin was absorbed 83.5% via intestinal route. Dihydroeponemycin belonged to Category 4 of toxicity. E3 is a potential drug target because of its different structure to that of the human. The C-score (confidence score of the prediction) of the active side E3 was 0.06 and E2 was 0.45. Dihydroeponemycin had the ability to bind to E3 and E2 with an affinity score binding of -3.8 and -4.1. The more negative the affinity binding value the easier the compound binds to the target protein. Based on this in silico study, dihydroeponemycin has potential effect as antimalaria by inhibiting Ubiquitin Proteasome System of Plasmodium falciparum.
Genomic Profile of rIR and rIRR in Type 2 Diabetes Mellitus Rat Model toward Effect of Goat Milk CSN1S2 Protein
Authors: Tambunan S H , Meidinna H N , Rohmah R N , Fatchiyah F 
Published: November 2019

Abstract
Diabetes mellitus is metabolic disorder with hypergycemia condition. Diabetes meilitus is commonly divided into two types, type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). The research focus was to determine the effect of CSN1S2 protein from Etawah Crossbred goat milk on DNA sequence of rIR exon 17 and rIRR exon 2 in T2DM rat model. The experimental rats were divided into four main groups, namely control group, diabetes group, control with CSN1S2 protein treatment group, and diabetes with CSN1S2 protein treatment group. We used 375, 750 and 1500 mg/kg BW of goat milk CSN1S2 protein for the treatment. The DNA was extracted from the rat liver, then amplified with a spesific primer of rIR and rIRR genes. The results of the amplification will be sequenced by using ABI 3730xl DNA Sequencer. The CSN1S2 protein treatment in rIR gene exon 17 did not affect a specific DNA sequence alteration. The diabetic rats treated with 375, 750 and 1500 mg/kg BW of CSN1S2 protein had the nucleotide changed to normal (3950A→3950G). Therefore, the CSN1S2 protein may have the function in triggering the DNA repair system.
Anti-Inflammation Assay of Black Soybean Extract and Its Compounds on Lipopolysaccharide-Induced RAW 264.7 Cell
Authors: Widowati W , Prahastuti S , Ekayanti N L W , Munshy U Z , Kusuma H S W , Wibowo S H B , Amalia A , Widodo W S , Rizal R 
Published: November 2019

AbstractInflammation response is related with various diseases. One of the useful therapeutic method to suppress inflammatory mediator synthesis is by application of compounds isolated from herbal medicine as treatment for inflammatory diseases. The aim of this study was to analyse the anti-inflammatory activity of black soybean extract (BSE), daidzein, and genistein troughin vitroanalysis of inflammatory mediators such as prostaglandin 2 (PGE2) and cytokines interleukin 1β (IL-1β), and tumor necrosis factor α (TNF-α). Safety of samples was determined by viability test using MTS (3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium). Concentration tested for viability assay were 40, 200, 1000 μg/mL for BSE, daidzein, and genistein. Anti-inflammation activity of samples was determined by ELISA quantification of PGE-2, TNF-α, and IL-1β in conditioned medium (CM) of supplemented pro-inflammatory activated RAW 264.7 cell. Inflammation on cells were induced by Lipopolysaccharide (LPS). BSE 1000 ug/ml, daidzein 1000 ug/ml, and genistein 1000 ug/ml treatments shows <80% cell viability average compared to control cell, indicating the treatments have cytotoxicity effect on RAW 264.7 cells. Hence, concentration used for treatments are 40 and 200 μg/mL for each sample. Genistein with concentration of 40 μg/ml treatment result shows highest anti-inflammatory activity which indicated from PGE-2, TNF-α, and IL-1β concentration. This study suggests that BSE, daidzein, and genistein with concentration of 40 and 200 μg/ml were safe to use for RAW 264.7 cell and genistein with concentration of 40 μg/ml have the best anti-inflammatory activity compared to daidzein and BSE.
Performance Analysis of Long Storage and Tidal Controlling Gate on the Flood of Kemuning River
Authors: Kustamar K , Susanawati L D , Nainggolan T H , Witjaksono A , Ajiza M 
Published: November 2019

Abstract
Kemuning river flood is caused by watershed (DAS) quality factor, river capacity, and tidal influence. Effort of controlling that has been done is by making reservoir in upper stream, river normalization in the urban area, and pump installation in the mouth of river. Yet those efforts are not significantly decreasing the frequency of flood. In this paper, it proposed the installation of controlling gate in the downstream of the pump location as a means of controlling, so the current can only move one direction to the downstream of the river. The gate design is planned according to the topography of the local riverbed and utilized it as a long storage. To know the effectiveness of the plan, the performance analysis of long storage and the gate on flood of Kemuning river is conducted. The result of analysis shows that the peak of maximum hydrograph discharge Q2; Q5; Q10; Q25; Q50, is (m3/second): 121.608; 192.720; 220.258; 241.605; 263.558. The combination of long storage and one direction gate cannot control the discharge of flood for two years, therefore to control flood it needs additional water reservoir and or flood pump.
Effect of particles size adsorbent of sugarcane bagasse and contact time on removal Pb(II) ions in wastewater by using vertical series column method
Authors: Umar H Z , Rahmahwati C A , Abubakar S , Samsul S 
Published: November 2019

Abstract
Amounts of heavy metals in wastewater can cause problems for living things and the environment. Handling efforts have been done with various methods. A relatively effective and efficient method is the adsorption. This study aims at removing Pb (II) in water using adsorbent of sugarcane bagasse with column system. The experimental design as a fixed variable consisted of 50 g of adsorbent, and 10 litres adsorbate volume, flow rate of 7 litres / minute. The independent variables consist of particle sizes with variations of 10; 20; 30 mesh and contact time with variation 0;5;10;15;20;30;60;90;120;150;180;210;240 minutes and the dependent variable of Pb(II) concentration (ppm). The results showed that the removal of Pb (II) was influenced by particle size factor of adsorbent and contact time. Universally the best removal power occurs on the size of 20 mesh adsorbent particles and with a contact time of 30 minutes. The fastest and highest removal percentage based on parameters of Pb(II) concentration for 10 mesh particles: 53.34% at contact time 180 minutes, 20 mesh particles: 54.84% at contact time 30 minutes, and 30 mesh particles: 65.67% at contact time 210 minutes.
Process of transformation dissemination radio broadcast content
Authors: Arief M 
Published: November 2019

Abstract
This study is motivated the development of broadcasting into a creative industry. Industries that produce ideas and ways of broadcasting of the content or information that can be consumed by the public. Packaging strategies and mechanisms broadcasting content requires creativity. This is commercialized broadcasting of creative industries. The mechanism of the presentation and delivery of content produced through the creative process that is the product of a creative industry broadcasting. Some radio in Bandung, to expand its range made a breakthrough in the use of Internet technology in the operation of the broadcast, including the use of social media in support the broadcast does. This paper is a qualitative study using case studies conducted by in-depth interviews, literature studies and observations. The validity of the research data triangulation technique was used to find out how the PRFM radio as one of the largest radio in Bandung, to broaden its reach has been doing ground breaking use of internet technology on its broadcast operations, the use of social media (Facebook) supporting broadcast. This research focuses on the transformation of the dissemination of current broadcast radio content using social media. With the presence of the new technology would allow the changes that need to be adapted to the culture and behaviour of the consumer.
Decision making system vocational high school election using promethee method
Authors: Agustina R , Dwanoko Y S , Susanto G , Kuswinardi W , Purwanto H L , Suprianto D 
Published: November 2019

Abstract
Vocational High School (SMK) is currently a good choice to continue Reviews their studies, programs offered by vocational schools are one of the factors of student interest, and this makes it difficult, for some parents to determine the right school for Reviews their children. Data and Information as a whole about Vocational Schools can be Obtained through the websites of each Vocational School but it is difficult, to compare them all together, because each has different achievements and advantages. Also, parents still do not know what factors are considered in choosing a vocational school and the tight competition in the world of education to determine the best for Reviews their children in accordance with Reviews their competence and parental conditions. The purpose of this study is to provide information and alternatives in the form of rankings in order to solve problems in the selection of Vocational High School so that it can help parents and the community to choose the right school for Reviews their children. The method used is Promethee as a model for making Recommendations for the selection of Vocational High School education places. The criteria used in the selection of high school vocational education places are location, facilities, number of achievements, school environment, and extracurricular activities. Results the recommendation system for selecting high school vocational education places using the Promethee method can provide information and provide alternatives to solve problems in the selection of secondary vocational schools.
Performance analysis of a standalone hybrid renewable electric generation system during fault condition
Authors: Pradipta A , Sunaryantiningsih I 
Published: November 2019

Abstract
There are several problems or disruptions to the hybrid system, including the availability of limited energy sources, transient conditions when some power plants or loads enter the system or out of the system and short circuit interruptions. The hybrid system used for testing includes photovoltaic system (PV), wind power generation system (WTGS), battery energy storage system (BESS) and load. The system is integrated on the DC bus. Testing for each interference condition is performed after the system is integrated. The parameters seen in this hybrid system performance analysis test are DC bus voltages and currents from each renewable plant. The results of this test will be used as data for hybrid system improvement in future research.
Development of technique to determine soil quality index for assessing soil condition
Authors: Rachman L M 
Published: November 2019

Abstract
An assessment of soil condition related to soil and soil use is still relies to soil type based on soil classification and land suitability class. Soil type and land suitability class cannot be used to evaluate soil condition/quality changes effectively. In many cases, soil type and land suitability class are remaining the same even there has been soil condition/quality change. Soil Quality Index (SQI) is the best solution to answer this circumstance. Two schemes proposed to determine SQI, i.e., Simple Scheme of SQI (SS-SQI) and Comprehensive Scheme of SQI (CS-SQI), both compose of few soil physical, soil chemical, and soil biology parameters with their own proportion then each soil properties are scored and finally summarized to get the total score. SS-SQI and CS-SQI consists of 13 and 20 soil properties, respectively. Field investigations supported by laboratorial analysis conducted at 48 locations in Banten Province, Indonesia. Results showed that average score of SS-SQI is similar or very close with average score of CS-SQI. The average SQI score is 4.486 and classified as slightly high. In the “numeral” form, SQI is easier, practical and much more sensitive used as a tool to monitor and evaluate change and dynamic of soil condition/quality.
New class of weak open sets via R*-interior and a decomposition of continuity
Authors: Manoharan R. , Prasanna Venkatesh L. 
Published: November 2019

Abstract
In this paper, some new class of sets R*I-S(X), R*I-P(X) and R*I-α(X) which are the collection of all ‘R*I-semi –open’, ‘R*I -pre-open’ and ‘R*I-α-open set’s are introduced and we analysed how the sets are related with them and examine the relationship the other similar collection of weak open sets in ideal and general topological spaces. Also we obtained an equivalent wayof representing continuous function interms of funcions which are defined using weak open sets in R*-topological spaces.
A Study on Soft s-closedsets, soft s-dense sets via Soft Ideals
Authors: Sebastian Lawrence J. , Manoharan R. 
Published: November 2019

Abstract
Thenotionofsoftsetsisintroducedasageneralmathematicaltool for dealing with uncertainty. In this work, we consider the concepts of soft closed set, soft dense setwere introducedinthesoftideal topologicalspace(SS(X)E, τ,
J
). Also, westudiedthe operations on this new soft s-closed and soft s-dense sets.
Mean Square Cordial Labeling on Star Related Graphs
Authors: Dhanalakshmi S , Parvathi N. 
Published: November 2019

Abstract
A Mean Square Cordial Labeling (MSCL) of a Graph G(V, E) with p vertices and q edges is a bijection from V to {0, 1} such that each edge uv is assigned the label

(

⌈

(
f

(
u
)

2

+
f

(
v
)

2

)
/
2

⌉

)

where ⌈x⌉ (ceil( x)) is the least integer greater than or equal to x with the condition that the number of vertices labeled with 0 and the number of vertices labeled with 1 differ by at most 1 and the number of edges labeled with 0 and the number of edges labeled 0 and the number of edges labeled with 1 differ by at most 1. In this paper it is analyzed that some star related graphs like Bistar graph B(k, k), Subdivision of a star graph S(Sk), Coconut tree CT(k, k), Merge graph Ck*Sk,, Graph PmΘ K1, n and Banana tree BT(k, k) admits mean square cordial labeling.
A solution approach to fully fuzzy linear fractional programming problems
Authors: Loganathan T. , Ganesan K. 
Published: November 2019

Abstract
In this paper, we propose a method of solving the fully fuzzy linear fractional programming problems, Express all the parameters and variables are triangular fuzzy numbers. Convert all the triangular fuzzy numbers in their parametric form, we convert the fractional programming problem in to a single objective linear programming problem in parametric form. We put new fuzzy arithmetic and fuzzy ranking, we obtain the optimal solution the given fully fuzzy linear fractional programming problem without converting to its equivalent crisp linear programming problem. A numerical example is provided to illustrate the efficiency of the proposed method.
An Approach For Solving Fuzzyassignment Problem Using Branch Andbound Technique
Authors: Mohanaselvi S. , Jayashree V. 
Published: November 2019

Abstract
This paper aims to obtain a minimum fuzzy assignment cost for a fuzzy assignment problem by using fuzzy branch and bound technique. Without transforming the fuzzy assignment problem into a corresponding crisp assignment problem a solution procedure to assign different resources to different activities is proposed to attain the fuzzy optimal cost. In this paper for comparing fuzzy numbers a ranking function in terms of parametric form is used. To showcase the proposed method an example is discussed and a comparison is made with a existing method.
Decision Makers Prference Solution for A Fuzzy Multi Objective Assignment Problem
Authors: Divya B. , Ganesan K. 
Published: November 2019

Abstract
In this paper we propose a novel approach for the solution of fuzzy multi objective assignment problem whose parameters are expressed as triangular fuzzy numbers. We apply arithmetic operations and ranking in the parametric form of triangular fuzzy numbers to solve fuzzy multi objective assignment problem without converting to classical form. The proposed method gives flexibility to the decision maker to his/her preferred fuzzy optimal solution. A numerical example is also given based on this novel method.