bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression
Authors: Pegoraro Anna , Orioli Elisa , De Marchi Elena , Salvestrini Valentina , Milani Asia , Di Virgilio Francesco , Curti Antonio , Adinolfi Elena 
Published: October 2020

AbstractAcute myeloid leukemia (AML) is a common adult leukemia often arising from a preexistent myelodysplastic syndrome (MDS). High mortality rates of AML are caused by relapse and chemoresistance; therefore, we analyzed the role of P2X7 receptor (P2X7R) splice variants A and B in AML progression and response to chemotherapy. The expression of P2X7RA and P2X7RB was investigated in samples obtained from MDS and AML untreated subjects or AML patients in relapse or remission after chemotherapy. Both P2X7RA and P2X7RB were overexpressed in AML versus MDS suggesting a disease-promoting function. However, in relapsing patients, P2X7RA was downmodulated, while P2X7RB was upmodulated. Treatment with daunorubicin (DNR), one of the main chemotherapeutics for AML, upregulated P2X7RB expression while reducing P2X7RA mRNA in AML blasts. Interestingly, DNR administration also caused ATP release from AML blasts suggesting that, following chemotherapy, activation of the receptor isoforms via their agonist will be responsible for the differential survival of blasts overexpressing P2X7RA versus P2X7RB. Indeed, AML blasts expressing high levels of P2X7RA were more prone to cell death if exposed to DNR, while those overexpressing P2X7RB were more vital and even protected against DNR toxicity. These data were reproducible also in HEK-293 cells separately expressing P2X7RA and B. P2X7RA facilitation of DNR toxicity was in part due to increased uptake of the drug inside the cell that was lost upon P2X7RB expression. Finally, in an AML xenograft model administration of DNR or the P2X7R antagonist, AZ10606120 significantly reduced leukemic growth and coadministration of the drugs proved more efficacious than single treatment as it reduced both P2X7RA and P2X7RB levels and downmodulated c-myc oncogene. Taken together, our data suggest P2X7RA and P2X7RB as potential prognostic markers for AML and P2X7RB as a therapeutic target to overcome chemoresistance in AML relapsing patients.
Coronavirus and Homo Sapiens
Authors: Natarajan Pooja , Kanchi Muralidhar , Gunaseelan Vikneswaran , Sigamani Alben , Harmon James , Belani Kumar 
Published: October 2020

AbstractThe Spanish influenza pandemic of 1918 globally claimed death between 50 and 100 million lives. In India, it was referred to as “The Bombay Fever,” and accounted for a fifth of the global death toll at that time. The current outbreak of the novel coronavirus disease 2019 (COVID-19), a new human-infecting beta coronavirus, has demonstrated that the size of an organism does not reflect on its ability to affect almost an entire human population. COVID-19, first detected in December 2019 in Wuhan, China, that spread rapidly worldwide. In humans, this disease ranged from flu-like symptoms to severe acute hypoxic respiratory failure. By appearance, this virus closely related to two bat-derived severe acute respiratory syndrome (SARS) coronaviruses. Although bats were likely the original host, animals sold at the Huanan seafood market in Wuhan might have been the intermediate host that enabled the emergence of the virus in humans. Under the electron microscope, the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus grips its receptor tighter than the virus behind the SARS outbreak in 2003 to 2004. The viral particle docks onto the angiotensin-converting enzyme 2 (ACE2) receptor and initiates viral entry. This review discusses the various aspects of the SARS-CoV-2 virus, its structure, pathophysiology, mechanism of interaction with human cells, virulence factors, and drug involved in the treatment of the disease.
Influence of Body Temperature on Bispectral Index-Guided Anesthetic Management in Off-Pump Coronary Artery Bypass Grafting
Authors: Kanchi Muralidhar , Nair Priya , Manjunath Rudresh , Belani Kumar 
Published: October 2020

Abstract
Background Perioperative hypothermia is not uncommon in surgical patients due to anesthetic-induced inhibition of thermoregulatory mechanisms and exposure of patients to cold environment in the operating rooms. Core temperature reduction up to 35°C is often seen in off-pump coronary artery bypass graft (OP-CABG) surgery. Anesthetic depth can be monitored by using bispectral (BIS) index. The present study was performed to evaluate the influence of mild hypothermia on the anesthetic depth using BIS monitoring and correlation of BIS with end-tidal anesthetic concentration at varying temperatures during OP-CABG.
Materials and Methods In a prospective observational study design in a tertiary care teaching hospital, patients who underwent elective OP-CABG under endotracheal general anesthesia, were included in the study. Standard technique of anesthesia was followed. BIS, nasopharyngeal temperature, and end-tidal anesthetic concentration of inhaled isoflurane was recorded every 10 minutes. The BIS was adjusted to between 45 and 50 during surgery.
Results There were 40 patients who underwent OP-CABG during the study period. The mean age was 51.2 ± 8.7 years, mean body mass index 29.8 ± 2.2, and mean left ventricular ejection fraction was 55.4 ± 4.2%. Anesthetic requirement as guided by BIS between 45 and 50 correlated linearly with core body temperature (r = 0.999; p < 0.001). The mean decrease in the body temperature at the end of 300 minutes was 2.2°C with a mean decrease in end-tidal anesthetic concentration of 0.29%. The reduction in end-tidal anesthetic concentration per degree decrease in temperature was 0.13%. None of the patients reported intraoperative recall.
Conclusion In this study, BIS monitoring was used to guide the delivery concentration of inhaled anesthetic using a targeted range of 45 to 50. BIS monitoring allowed the appropriate reduction of anesthetic dosing requirements in patients undergoing OP-CABG without risk of awareness. There was a significant reduction in anesthetic requirements associated with reduction of core temperature. The routine use of BIS is recommended in OP-CABG to titrate anesthetic requirement during occurrence of hypothermia and facilitate fast-track anesthesia in this patient population.
The local co-evolution of firms and governments in the Information Age
Authors: Lundan Sarianna , Cantwell John 
Published: October 2020

AbstractThe governance structures of the value-creating activities of MNEs have evolved towards more networked forms that are geographically highly concentrated and involve partnering with diverse actors. The experimentation that takes place within these corporate networks has a parallel on the government side, where subnational governments, and particularly cities as hubs of economic activity, have increased their profile and level of cooperative activity. We argue that engagement in these partnerships is an essential way in which firms and governments co-evolve and create the basis for sustainable economic growth in the Information Age. While the origins of this collaborative form of governance reside in the increasing knowledge intensity of value creation, its implications go far beyond MNE value creation and capture, extending to issues of global governance such as climate change and sustainable development goals. We examine the implications of this process of co-evolution both in terms of the costs of developing the requisite corporate capabilities as well as the legitimacy of these efforts as part of a deliberative democracy.
Combined Properties of Al/Ni Reactive Multilayer Films During High-Rate Heating Using a Pulse of Current
Authors: Wang Yao , Guo Fei , Zhou Qin , Jiang Hongchuan , Li Yong , Wang Liang 
Published: October 2020

Abstract
We use pulses of current to investigate the combined properties of Al/Ni multilayer films under high-rate heating by measuring current-voltage waveforms and the flyer velocity. Explosion occurs earlier in the Al/Ni multilayer foil than in the Al and Ni films, suggesting that the addition of Al/Ni affects the electrical exploding process, which is not controlled solely by resistance. The experiments indicates that the differences between the physical properties of the Al and Ni films is a factor to causing higher plasma electron temperature and absorb more electrical energy than the single Al or Ni film. The flyer velocity of the Al/Ni multilayer film is much lower than that of the Al film due to the high adiabatic index of Ni.
Study on Annealing Effect of Fe51.6Co34.4Hf7B6Cu1 Amorphous Alloy
Authors: Zhang Yanhui , Guo Jiaqi 
Published: October 2020

Abstract
Microwave absorbing materials have a wide range of applications in both military and civil areas. Fe-based amorphous alloys have superior soft magnetic properties, which possess high permeability and high saturation magnetization. The studies on Fe-based amorphous materials have a high theoretical and practical value. In this article, the effect of different temperatures treatments on Fe51.6Co34.4Hf7B6Cu1 amorphous alloy prepared by melt-spun technique is investigated. The traces of crystalline phase are precipitated from the treated sample. The volume percentages of crystalline phase are 2.1% and 7.4% in the annealed samples at 200 °C and 300 °C, respectively. The microwave absorption performance of the microcrystalline samples after isothermal heat treatment is better than the other.
Determination of Fe in Graphene by Inductively Coupled Plasma Optical Emission Spectrometer
Authors: Lu Yi , Gong Chen , Wu Lijun , Liu Hongchao , Guo Guojian 
Published: October 2020

Abstract
The Fe in graphene was determined by inductively coupled plasma optical emission spectroscopy. The effects of digestion temperature, digestion system, analyzing spectral line, RF power, peristaltic pump flow rate, and working gas flow rate on the measurement results were investigated respectively. The results show that the best digestion effect appear when the digestion temperature is 550 °C and the digestion system is 3ml hydrochloric acid combined with 1ml nitric acid. The most stable and reliable test results obtained when the analyzing spectral line is 259.941 nm, the RF power is 1400W, the peristaltic pump flow rate is 50r/min, the atomizing gas flow rate is 0.8L/min, and the auxiliary gas flow rate is 1.0L/min. The detection limit of the measurement result is 0.029mg/L, the relative standard deviation (n=6) is between 2.5% and 3.2%, and the recovery is between 96.3% and 108.2%.
Transient Bending Vibration of a Piezoelectric Semiconductor Nanofiber under a Harmonic Shear Force
Authors: Liang Yuxing 
Published: October 2020

Abstract
A harmonic shear end force induced the transient bending vibration is analyzed in a cantilevered n-type ZnO nanofiber. Based on the mechanical movement equation, continuity condition of current density and charge equation of electrostatics, the theoretical analysis is carried out by a one-dimensional model. The evolution of the deflection and perturbation of the electron concentration caused by the harmonic end force are calculated. Numerical results show that the vibration period of the piezoelectric semiconductor fiber is about twice that of the harmonic force, which referenced to design the nanosensors and nanogenerators.
Analysis of Potential and Electron Density Behaviour in Extremely Scaled Si and InGaAs MOSFETs Applying Monte Carlo Simulations
Authors: Islam Aynul , Aynul Anika Tasnim , Kalna Karol 
Published: October 2020

Abstract
Scaling of Silicon and InGaAs MOSFETs of a 25 nm gate length till shortest gate length of 5 nm, simulated this nano-device by Monte Carlo (MC) with quantum corrections. The transistors are scaled-down only in lateral dimensions in order to study electron transport approaching a ballistic limit along the scaled channel following experimental works. These MC simulations are able to give detailed insight into physical behaviour of electron velocity, electron density, and potential in relation to the drive current. We found that electron peak velocity increases during the scaling in Si MOSFETs till the 10 nm gate length and then dramatically declines due to a strong long-range Coulomb interaction among the source and the drain [16]. This effect is not observed in the equivalent InGaAs MOSFETs in which electron peak velocity exhibits double peak which steadily increases during the scaling [16]. However, the increasing of current in the equivalent InGaAs MOSFETs is moderate, by about 24 %, by comparing of current in the Si MOSFETs of 74 % delivered by 5 nm channel transistor.
Novel Responsive Controllable Solidification Plugging Agent to Overcome Lost Circulation Problems in Long Open Hole Intervals
Authors: Li Long , Yin Da , Hao Weiwei 
Published: October 2020

Abstract
A new type of responsive controllable solidification plugging agent (RCSP) for long open hole intervals was developed, and the sealing characteristics were evaluated. RCSP had the characteristics of rapid water loss, high filter-cake consistency and good residence capacity. The experimental results indicated that the maximum pressure-bearing capacities of plugged zones in 5 mm and 10 mm slotted templets are 16.6 MPa and 11 MPa, respectively. So RCSP is an effective plugging agent for strengthening wellbore stability. RCSP is appropriate for sealing wide range of fracture sizes. Using RCSP-based plugging mud to address lost circulation problems in troublesome thief zones is a very powerful and economical approach. In the future, RCSP might hold great promise to resolve lost circulation problems in multiple leakage zones in long open hole sections.
The Corrosion Behaviour of Amorphous Metal Fiber Compared With That of Stainless Steel Fiber
Authors: Wu Zhongwang , Jia Yuwei , Jin Zili , Ren Huiping , Ni Xiaojun 
Published: October 2020

Abstract
Amorphous metal fiber exhibits high corrosion resistance, excellent mechanical properties and is good material for reinforcing concrete matrix. To compare with the corrosion behaviour of amorphous metal fiber and stainless steel fiber, the corrosion resistance was investigated by electrochemical polarization in 0.5 M H2SO4, 0.1 M FeCl3 and 3.5 wt% NaCl solutions, respectively. The results show that amorphous metal fiber exhibits more superior corrosion resistance than that of stainless steel fiber. The amorphous metal fiber has excellent pitting corrosion resistance in 3.5 wt% NaCl solution, and the stainless steel fiber is susceptible to pitting corrosion. The amorphous metal fiber is spontaneously passivated in 0.1 M FeCl3 solutions, and the stainless steel fiber doesn’t form passivation.
Investigation on Impact Induced Damage in Boron Carbide with Simultaneous X-ray Imaging and Diffraction
Authors: Zhou Lijiang , Xu Songlin , Peng Weicai 
Published: October 2020

Abstract
The macro-scale mechanical behaviors of materials under impact can be dominated by the meso and micro-scale deformation mechanisms and cracking patterns. In combination with the X-ray imaging and diffraction techniques, impact tests are performed on boron carbide (B4C) ceramic bulks with two different porosities by a miniature split Hopkinson pressure bar (SHPB). After a transient quasi-elastic deformation process, catastrophic failure occurs in the high-porosity bulk, with a weak failure strength. Abundant tensile and shear cracks nucleate in the low porosity bulk, but cannot connect into a cracks network due to the high adhesive force, and finally the dissociative failure occurs with several main cracks penetrating. By analyzing the diffraction peak splitting phenomenon, the extent of shear deformation is quantitatively characterized to be 60-70% of the compression deformation. The damage extent is expressed by the voids volume induced by cracks. The macroscopic stress increment of B4C bulk under impact can be expressed by a function of the damage extent evolution.
Preparation and Parameters Measurement of Magnetic Fluid
Authors: Hao Ruican , Liu Huagang , Wang Shang 
Published: October 2020

Abstract
Magnetic fluid is a liquid nano-size magnetic material which has unique properties such as flowability, paramagnetism, and magnetic permeability. The composition of magnetic fluid was introduced. The preparation devices were collected and listed. The preparation of magnetic particles was made by chemical coprecipitation. The particles were coated with surfactant in the experiment. Then the coated particles were added in the base carrier fluid according to the procedure of preparation. Magnetic fluid was prepared by chemical coprecipitation. The parameters of magnetic fluid were measured for kinds of engineering applications. The magnetism of magnetic fluid is one of the most important parameters, which was measured and displayed. The saturated magnetism should be increased for more applications.
Effects of Temperature and Strain Rate on Mechanical Behaviour of Laser Rapid Forming Ti-6Al-4V Alloy
Authors: Xiang Wenli , Shu Xinzhu , Sun Kun 
Published: October 2020

Abstract
Using the electronic universal test machine, the high temperature split Hopkinson bar and the gleeble-1500 thermal simulator, the room temperature quasi-static compression experiment, room temperature dynamic compression experiment, high temperature dynamic compression experiment and the high temperature quasi-static compression experiment on corresponding cylindrical samples of Laser Rapid Forming Ti-6Al-4V(LRF TC4) titanium alloy have been conducted, respectively. And effects of the temperature and strain rate on mechanical behavior of LRF TC4 alloy have been investigated. It is showed that, whether quasi-static compression or high strain rate compression, the strength of LRF TC4 decreases and the plasticity increases at the high temperature. Under the high temperature quasi-static compression, LRF TC4 still has the strain strengthening effects at 400°C, the flow stress changes steadily in the stage of the plastic deformation at 500°C and the strength of LRF TC4 dropped drastically when the temperature goes beyond 500°C. Under the high temperature and high strain rate, the flow stress changes steadily in the plastic deformation stage due to dual function of both strain rate strengthening and temperature softening and adiabatic temperature rise within the sample reduced with the increase of the deforming temperature. Under the coupling function of high temperature and high strain rate, the effect of strain-rate strengthening is weaker than the effect of temperature softening.
Effect of Microstructure on the Johnson-Cook Constitutive Model Parameters of Ti-6Al-4V Alloy
Authors: Ren Yu , Ma Yuantong , Pan Qiyun 
Published: October 2020

Abstract
Constitutive models are widely used to predict the mechanical behavior of materials. In this research, the Johnson-Cook (J-C) constitutive model parameters of Ti-6Al-4V (Ti64) alloy with different microstructural details were fitted based on the mechanical properties over a broad range of strain rates and temperatures. The results indicate that the microstructural details have a significant effect on the mechanical properties and the J-C model parameters of Ti64. The five material parameters (A, B, n, C, m) in J-C model of Ti64 exhibit completely different varying trends as a function of the equiaxed primary α-phase volume fraction and α-platelet thickness. These changes in J-C model parameters of Ti64 can be attributed to the effect of microstructural details on the dislocation nucleation and motion under different deformation conditions.
The Application of Grouting Sealing Material in the Treatment of Pavement Reflective Cracking
Authors: Liang Hao , Song Xiaojin , Jiang Feng , Wei Hui 
Published: October 2020

Abstract
Grouting sealing technique was applied for the treatment of pavement reflective cracking in HengDe expressway and the treatment effect which evaluated by the portable falling weight deflectometer was demonstrated in this paper. Analysis considers that grouting sealing technique could effectively improve the bearing capacity of the pavement where distress happened by reducing the deflections of the pavement up to 5%-25%.
Reliable Resistive Switching Behaviour of Ag/Ta2O5/Al2O3/p++-Si Memory Device
Authors: Tian Wei , Ilyas Nasir , Li Dongyang , Li Chunmei , Jiang Xiangdong , Li Wei 
Published: October 2020

Abstract
In this article, we demonstrate a resistive switching memory device based on a very simple bilayer structure of Ag/Ta2O5/Al2O3/p++-Si. As compared to a single-layer based device of Ag/Ta2O5/p++-Si, a uniform bistable resistive switching behaviour with on/off ratio over 104 demonstrates that the Ag/Ta2O5/Al2O3/p++-Si device could be a promising candidate for the memory device, in which the total resistance could also be adjusted by modifying the applied electric field. In the low voltage sweeping region, gradual increase and/or decrease in resistance can also be observed, indicating that an analog type of switching behaviour similar to the first demonstrated memristor device has also been observed in the newly made device. This study could open up new ways for the design of multi-functional devices which are promising for memory and neuromorphic computing applications.
Study on the Influence of the Migration of Heavy Metals in 50Cr15MoV Kitchen Knives
Authors: Chen Jiaxin , Chen Yuan , Lin Hehai 
Published: October 2020

Abstract
25 batches of 50Cr15MoV kitchen knives were analyzed by chemical composition analysis, surface roughness testing, corrosion resistance testing, metallographic examination, scanning electron microscopy. The results show that:(1) there is no linear relationship between the heavy metal migration of 50Cr15MoV kitchen knives and its corresponding element content, and there is no correlation between the heavy metal migration and the surface roughness; (2) The heavy metal migration of kitchen knives is significantly correlated with corrosion resistance, and the heavy metal migration is positively correlated with the corrosion points in statistics; (3) The heavy metal migration of the kitchen knives with the same material of 50Cr15MoV varies greatly, which is closely related to the microstructure of the kitchen knives. The morphology and distribution of carbide microstructure and the heat treatment process of products have great influence on the heavy metal migration of kitchen knives.
Memristive Behaviour of Ag-doped-HfO2 Thin Films Prepared by Magnetron Sputtering
Authors: Chen Pengyu , Ilyas Nasir , Li Chunmei , Li Dongyang , Jiang Xiangdong , Li Wei 
Published: October 2020

Abstract
The bipolar resistive switching is suitable for the applications of information storage, logical operation and neuromorphic computation. This paper reports the bipolar resistive switching behaviour in HfO2:Ag-based memristive device. Under DC sweeps, the Ag/HfO2:Ag/p++-Si device showed a uniform bipolar resistive switching feature with a resistance ratio of ~15. Moreover, in the low voltage sweeping region, the device showed analog resistive switching behaviour with gradual SET and gradual RESET characteristics. It is suggested that the formation/rupture of Ag-filament is crucial in the resistive switching, and the gradual changes in resistance might have resulted from the dissolution of Ag atoms from active Ag top electrode (TE) rather than only from local migration of Ag atoms inside the dielectric layer. This new memristor structure with the analog resistive switching is expected for the future application of memristor as a nonvolatile memory and neuromorphic computing.