bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale of perspective directions of standardization of medical care of the population of Ukraine at the turn of 2020
Authors: Diachuk D.D. , Zyukov O.L. , Lishchyshyna O.M. 
Published: November 2020

Abstract. The state of standardization of healthcare services to the population of Ukraine has to be critically analyzed and compared with the basic European recommendations on methodology. Since the standardization of healthcare services usually takes place under complex national conditions and is a component of the quality management system, we aimed to determine whether the methodology for standardizing healthcare services in Ukraine is consistent with the methods used in countries with strong economies. Aim: to determine whether the implementation and development of the methodology for standardizing healthcare services to the population of Ukraine corresponds to the approaches in the European Union, and to substantiate promising directions for improving the standardization of healthcare services to the population of Ukraine at the turn of 2020.
Materials and methods. A historical analysis of the normative documents that currently define the methodology of standardization of healthcare services in Ukraine and their comparative analysis with the EU acquis in health care have been carried out.
Results and discussion. Since the main responsibility for improving the quality of healthcare services belongs to government institutions, the common documents of the European Union on this issue are recommendative in nature. At the same time, a comparative analysis made it possible to identify the main achievements and gaps in the methodological support of standardization in the healthcare sector in Ukraine, to substantiate the directions for improving the standardization of healthcare services to the population of Ukraine at the turn of 2020.
Conclusion. At the beginning of 2020, the methodology for standardizing healthcare services in Ukraine partially corresponds to the approaches typical of the European Union. At the present stage, improving the quality of healthcare services in Ukraine requires strengthening the accountability of government agencies, improving the procedure for implementing and updating health standards in accordance with existing data, establishing a connection between the quality criteria of healthcare services, the drug formulary and the list of available equipment based on a single evidence base and a single conceptual and terminological thesaurus, monitoring the compliance with standards and tariffs for medical (pharmaceutical) services through pilot implementation, monitoring of clinical indicators. The progress in these areas is possible providing that the methodology of evidence-based medicine is followed, with the broad involvement of healthcare professionals and healthcare service receivers.
RISK OF EMOTIONAL BURNOUT SYNDROME IN STUDENTS IN TERMS OF PUBLIC HEALTH
Authors: Palamar B. I. , Gruzieva T. S. , Palamar S. P. , Tukaev S. V. , Rudichenko V. M. , Misai A. B. 
Published: November 2020

Summary. One of the phenomena of personal deformation is emotional burnout (EB). Emotional burnout syndrome (EBS) can occur during studying in institution (university) and become an obstacle in its process. EBS affects up to 40% (students) of young people studying. Components of learning: social comparison and evaluation, dissatisfaction with the process and the result of learning, feelings of injustice in the assessment of knowledge, unjustified hopes, difficulties in communication are factors of emotional burnout.
Aim. To determine the presence and influence of negative factors on the possibility of emotional burnout in students of higher educational institutions.
Materials and methods. A one-step (transverse) study was conducted. Social networks popular among students – Telegram, Instagram – were chosen to distribute the questionnaire. In particular, the survey form was sent in such chats as NMU, KT-18, LNTU students, conversations of students of NMU named after O.O. Bogomolets, National University “Lviv Polytechnic” and Borys Hrinchenko Kyiv University.
Results and discussion. When analyzing the data according to the specialization of the higher educational institution and the year of study, attention is drawn to the increase in the percentage of students studying medicine, dentistry, pharmacy according to the years of study who force themselves to work (learn subjects) despite fatigue. These are the students of second grade – 8.33%, third – 23.86%, and fifth one 25%. The number of such students studying philology tends to decrease from 100% in the third study year to 25% in the fourth one. The number of third-year students who try to study despite fatigue, in the field of economics, philology and management and marketing is greater than among students who study in the field of medicine, dentistry and pharmacy. 33.3%, 100%, 28.5% against 23.8%, respectively.
Conclusions. Based on the results obtained, it can be concluded that with each study year, the percentage of students who feel depressed due to learning difficulties, who feel tired and unwilling to study in senior grades, is growing. It was also detected that in senior grades among students who experience chronic fatigue, the use of psychoactive substances is highly spread. Among the surveyed students, there is a high percentage of probable risk of development of the syndrome of emotional burnout (SEB). It is specified that the percentage of probable risk of SEB increases with each year of study. It was found that medical students tend to feel chronic fatigue and the need for additional motivation to study earlier than other students. Computer science students were the least likely to develop emotional burnout.
Features of revascularization of the lower extremity in patients with diabetic foot
Authors: Shapovalov D. , Hupalo Y. , Shaprynskyi V. , Shamray-Sas A. , Kutsin A. , Gurianov V. 
Published: November 2020

Objective: To determine specific features of peripheral arterial diseases in patients with diabetic foot that influence the choice of revascularization method.
Introduction. Peripheral arterial diseases in patients with diabetic foot (PAD/DF) have significant differences in pathogenesis, manifestations and course compared with peripheral arterial diseases (PAD). These differences cause creating classifications to access severity PAD/DF and PAD separately. But approaches to revascularizations in PAD/DF and PAD remain the same.
The choice of revascularization method taking into account the features can significantly improve its results.
Materials and methods. We analyzed results of 98 revascularizations of 77 lower extremities in 74 patients in the period from 2014 to 2019рр. Angioplasties were performed 72,3%, open operations – 21,4%, hybrid procedures 6,1%.
Results. Amputation-free survival during the year was 84,6%. Healing of trophic disorders during the year was 70,5%.
Conclusions. At the diagnostic stage, patients with PAD and PAD / DM should be separated for creating the optimal treatment plan and the choice of revascularization technique. Different approaches to the PAD/DF patients can improve the results of revascularizations.
Abbreviations and defititions
PAD (peripheral arterial diseases) - atherosclerotic occlusive diseases of the lower extremity arteries.
DF (diabetic foot) - infection, ulceration or destruction of tissues of the foot associated with neuropathy and/or peripheral artery disease in the lower extremity of a person with (a history of) diabetes mellitus.
PAD/DF - peripheral arterial diseases in persons with diabetes mellitus.
LICHEN SCLEROSUS OF THE VULVA IN PATIENTS WITH LIMITED SCLERODERMA
Authors: Tatarchuk T.F. , Protsenko T.V. , Dunaevskaya V.V. 
Published: November 2020

Modern literature information on the etiopathogenetic prevalence of lichen sclerosus has been presented by the authors; clinical manifestations and classification of the disease have been outlined; diagnosis and treatment issues have been discussed in the article. 3 clinical cases of genital lesions in the form of lichen sclerosus in patients with limited scleroderma have been described. In our opinion, lichen sclerosus is one of the forms of limited scleroderma.
Purpose. To investigate the conditions for the diagnosis and treatment of genital lesions in the form of lichen sclerosus in patients with limited scleroderma.
Methods. The first line of therapy for lichen sclerosus is the use of super-powerful topical glucocorticoids. Clobetasol propionate 0.05% is to be used for 3 months (1 month daily, then every other day for a month, then 2 times a week for a month). After 3 months of treatment, if a positive effect is declared, maintenance therapy is recommended once a week. Topical calcineurin inhibitors are recommended as a second-line therapy. Effective and safe excipients are emollients that moisturize the skin and mucous membranes, prevent transdermal fluid loss, and reduce subclinical inflammation. The possibility of using triamcinolone (1-2 mg) onto pathologically altered tissue in women with lichen sclerosus where there are hyperkeratotic sites resistant to GCS can be considered after exclusion of intraepithelial neoplasia or malignant transformation. The effectiveness of physiotherapeutic methods, such as low-intensity helium-neon laser radiation in the red or infrared range, treatment with sunlight and radiation generated by medical equipment, photodynamic therapy has been described.
Results. One of the important measures is the elimination of irritating factors, as well as careful care of the vulva and the treatment of secondary infection. It consists in adherence to a diet (exclusion of spicy, salty, sweet foods, caffeine-containing products, alcohol) and intimate hygiene rules (limitation / exclusion of soap-containing products, deodorants, synthetic underwear, pads, tampons). The underwear should not be very tight. In addition, patients should exclude mechanical irritation of the affected area, including shaving. With extreme manifestation of itching, it is recommended to prescribe desensitizing therapy and sedatives.
Conclusions. Clinical cases of practical interest in connection with the clinical manifestations of limited scleroderma on the skin and genitals have been considered. Frequent lesions of the genital organs in the form of a typical clinic of lichen sclerosus in women suffering from limited scleroderma, the similarity of their clinic, histological picture and pathogenesis have been noted. All this gives a reason to consider lichen sclerosus as a manifestation of limited scleroderma.
VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY IN RURAL MALES WITH ARTERIAL HYPERTENSION: THE POSSIBILITIES OF MODIFYING IN REAL CLINICAL SETTINGS
Authors: Nimtsovych T.I. , Mikhaliev К.О. , Kravchenko A.M. , Gurianov V.G. , Chursina T.Ya. , Mishcheniuk O.Yu. , Stanislavska S.S. 
Published: November 2020

Purpose: to establish the possibilities of modifying blood pressure visit-to-visit variability (VVV) in rural males with arterial hypertension (HTN) by the use of antihypertensive therapy (AHT), considering also the correction of dyslipidemia and certain lifestyle aspects, as well as the changes in compliance with pharmacotherapy (CP).
Material and methods. The prospective study enrolled 160 rural males with uncomplicated primary HTN (mean age 50 ± 6 years). Seventy three (45,6 %) patients were overweight; 85 (53,1 %) patients were active smokers. An alcohol consumption ≥1 time per week was pointed out by 77 (48,1 %) males. VVV (of systolic (SBP) and diastolic blood pressure (DBP)) was assessed by means of standard deviation (SD) and coefficient of variation (CV). We prescribed a fixed perindopril/amlodipine (P/A) combination, with indapamide (IND) addition as required. With the aim dyslipidemia correction, we prescribed atorvastatin (daily doses 10-40 mg). Optimal CP was pointed out by 37 (23,1 %) patients.
Results. At 1yFU, all enrolled patients achieved SBP/DBP targets (<140/90 mm Hg), and strict SBP/DBP targets (<130/80 мм Hg) were achieved in 159 (99,4 %) cases. More than 90 % of patients achieved the following prespecified «target» BP VVV levels: SD (SBP) <4,8 mm Hg; CV (SBP) <3,9 %; SD (DBP) <3,7 mm Hg; CV (DBP) <5,1 %. Aimed to predict SD (SBP) reduce >9,7 mm Hg probability at 1yFU, we built the 6-factors logistic regression model: 1) improvement and maintenance of optimal CP (by MGLS) (β = 1,27; р<0,001); 2) body mass index reduce >1,3 kg/m2 (β = 0,57; p=0,035); 3) alcohol consumption modifying (0,72; p=0,007); 4) optimal compliance with atorvastatin daily doses 30-40 mg (1,25; p<0,001); 5) smoking status modifying (0,43; р=0,097); 6) SBP reduce >46,7 mm Hg (0,47; р=0,098). The probability of status «reduction of SD (SBP) >9,7 mm Hg at 1yFU» increase was associated with the higher sum of predictors` β-coefficients.
Conclusions. In rural HTN males, at 1yFU, the AHT (based on P/A, with IND addition as required) favored the significant blood pressure VVV reduction in the vast majority of cases. The SBP VVV reduction was determined to be additively affected by the modifying of certain factors, as well as by achievement and maintenance of maximum CP.
Decentralized navigation model for multiagent cooperative robotic systems
Authors: Jiménez Andrés C. , García-Díaz Vicente , Bolaños Sandro 
Published: November 2020

On November 20, 2018 at 11 am, Andrés Camilo Jiménez Alvarez defended his Ph.D. thesis entitled Decentralized navigation model for multiagent cooperative robotic systems at the Distrital University Francisco José de Caldas. Andrés Camilo Jiménez Alvarez presented his dissertation in a public open event held in the “Wise Caldas Auditory”, and was able to expose and defend all his research, it was approved by the committee. The thesis was supervised by his advisors, Vicente García-Díaz and Sandro Javier Bolaños, together with the thesis committee, Rubén Gonzáles Crespo, Oscar Fernando Avilés and Roberto Ferro Escobar. All the cited people were present at the event.
Home packed food for nursery children in United Arab Emirates provides suboptimal quality
Authors: Garemo Malin , Elamin Amal , Gardner Andrew 
Published: November 2020

BACKGROUND: Early childhood nutrition is associated with health outcomes later in life, hence developing health promoting habits from an early age is imperative. OBJECTIVE: The aim of this study was to assess the nutritional adequacy of home-packed food brought to the nurseries by attending children. METHODS: In a cross sectional study conducted in 7 nurseries in Abu Dhabi, United Arab Emirates 315 food-boxes were assessed through detailed food observations at the nurseries prior to mealtimes. The food content was evaluated using the Alberta Guidelines for nursery food, Canada. RESULTS: Most food boxes contained refined grains (77.5%), fruits (74.6%), sweet/full fat dairy products (77.5%), discretionary-calorie-food-items (70.6%). Emirati children were offered sweetened drinks significantly more ( p < 0.001). Non-dairy protein sources, vegetables, low-fat-natural-dairy products were offered to 45.4%, 44.1% and 3.9% of children, respectively. Overall, 70.2% of the food-boxes contained not-recommended food and 63.1% of the children were served a very poor food combination. CONCLUSIONS: Despite frequent inclusion of recommended food, many food boxes were nutritionally inadequate due to their low content of whole grains, low-fat dairy products, vegetables and animal proteins and high content of sweet food and drinks. The inadequate dietary patterns necessitate developing nutrition guidelines for nurseries in Abu Dhabi.
Health and nutrition literacy in adults: Links with lifestyle factors and obesity
Authors: Michou Maria , Panagiotakos Demosthenes B. , Lionis Christos , Costarelli Vassiliki 
Published: November 2020

BACKGROUND: Low Health Literacy (HL) and Nutrition Literacy (NL) are associated with serious negative health outcomes. OBJECTIVES: The aim of this study was to investigate certain lifestyle factors and obesity, in relation to HL and NL. METHODS: This cross-sectional study was conducted in the urban area of the Attica region, in Greece. The sample consisted of 1281 individuals, aged ≥18 years. HL, NL sociodemographic characteristics and lifestyle factors (physical activity, smoking status, alcohol consumption,) were assessed. Mann-Whitney U, the Kruskall Wallis, Pearson chi-square tests and multiple linear regression models were used. RESULTS: Linear regression analysis has shown that smoking, alcohol consumption and physical activity, were associated with HL levels (–1.573 points for ex-smokers in comparison to smokers, p = 0.035, –1.349 points for alcohol consumers in comparison to non-consumers, p = 0.006 and 1.544 points for physically active individuals to non-active, p = 0.001). With respect to NL levels, it was also not associated with any of these factors. Obesity was not associated with HL and NL levels. CONCLUSIONS: Certain lifestyle factors, including physical activity, are predicting factors of HL levels, in Greek adults. The results contribute to the understanding of the relationship between lifestyle factors and HL and should be taken into account when HL policies are designed.
Pemberdayaan Teman Sebaya Dalam Meningkatkan Pengetahuan Gizi Remaja Kelebihan Berat Badan
Authors: Wahyuningsih Retno 
Published: November 2020

Background : Being overweight in adolescents needs to be addressed early so as not to become a health problem in the future. Adolescents who are obese can be treated with peer education. Methods : Quasi-experimental, randomized pre-post control group on 39 high school students aged 14-18 years were divided into two groups: 1) a treatment group with peer nutrition counseling, 2 control groups with classical counseling. Results : Research that differentiates the knowledge before and after peer counseling (treatment group) with a significance of 0.000 (p <0.05), and the control group (classical counseling) with a significance of 0.001 (p <0.05). Conclusion : Peer counseling can increase knowledge.
Editorial
Authors: Chakraborty Rhyddhi 
Published: November 2020

Public health system always requires an advanced level of awareness and a comprehensive policy. However, as is often the case, expectations and actualities do not match. In order to understand the situation, planning and other related initiatives, and to assess the adequacy in terms of the expectations borne out of experiences, the papers in this volume detailed the issues and the need of ethics in formulating the policies and contributing in the vision of the development of the country.
In order to have a comprehensive ethical policy and planning, a concern for the initiatives and development deep down in the policy formation is required. Despite the fact that there is need of ethics in such formulation, the need is yet to be acknowledged in the relevant policy documents. The five papers in the volume emphasise such need.
Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils
Authors: Lee Jungnam , Lu Yuanqing , Oshins Regina , West Jesse , Moneypenny Craig G. , Han Kyudong , Brantly Mark L. 
Published: November 2020

Alpha 1 antitrypsin deficiency (AATD) is an autosomal co-dominant disorder characterized by a low level of circulating AAT, which significantly reduces protection for the lower airways against proteolytic burden caused by neutrophils. Neutrophils, which are terminally differentiated innate immune cells and play a critical role to clear pathogens, accumulate excessively in the lung of AATD individuals. The neutrophil burden in AATD individuals increases the risk for early-onset destructive lung diseases by producing neutrophil products such as reactive oxygen radicals and various proteases. The level of AAT in AATD individuals is not sufficient to inhibit the activity of neutrophil chemotactic factors such as CXCL-8 and LTB4, which could lead to alveolar neutrophil accumulation in AATD individuals. However, as neutrophils have a short lifespan, and apoptotic neutrophils are rapidly cleared by alveolar macrophages that outnumber the apoptotic neutrophils in the pulmonary alveolus, the increased chemotaxis activity does not fully explain the persistent neutrophil accumulation and the resulting chronic inflammation in AATD individuals. Here, we propose that the ability of alveolar macrophages to clear apoptotic neutrophils is impaired in AATD individuals and it could be the main driver to cause neutrophil accumulation in their lung. This study demonstrates that Z-AAT variant significantly increases the expression of pro-inflammatory cytokines including CXCL-8, CXCL1, LTB4, and TNFα in LPS-treated macrophages. These cytokines play a central role in neutrophil recruitment to the lung and in clearance of apoptotic neutrophils by macrophages. Our result shows that LPS treatment significantly reduces the efferocytosis ability of macrophages with the Z-AAT allele by inducing TNFα expression. We incubated monocyte-derived macrophages (MDMs) with apoptotic neutrophils and found that after 3 h of co-incubation, the expression level of CXCL-8 is reduced in M-MDMs but increased in Z-MDMs. This result shows that the expression of inflammatory cytokines could be increased by impaired efferocytosis. It indicates that the efferocytosis ability of macrophages plays an important role in regulating cytokine expression and resolving inflammation. Findings from this study would help us better understand the multifaceted effect of AAT on regulating neutrophil balance in the lung and the underlying mechanisms.
Establishing Live-Cell Single-Molecule Localization Microscopy Imaging and Single-Particle Tracking in the Archaeon Haloferax volcanii
Authors: Turkowyd Bartosz , Schreiber Sandra , Wörtz Julia , Segal Ella Shtifman , Mevarech Moshe , Duggin Iain G. , Marchfelder Anita , Endesfelder Ulrike 
Published: November 2020

In recent years, fluorescence microscopy techniques for the localization and tracking of single molecules in living cells have become well-established and are indispensable tools for the investigation of cellular biology and in vivo biochemistry of many bacterial and eukaryotic organisms. Nevertheless, these techniques are still not established for imaging archaea. Their establishment as a standard tool for the study of archaea will be a decisive milestone for the exploration of this branch of life and its unique biology. Here, we have developed a reliable protocol for the study of the archaeon Haloferax volcanii. We have generated an autofluorescence-free H. volcanii strain, evaluated several fluorescent proteins for their suitability to serve as single-molecule fluorescence markers and codon-optimized them to work under optimal H. volcanii cultivation conditions. We found that two of them, Dendra2Hfx and PAmCherry1Hfx, provide state-of-the-art single-molecule imaging. Our strategy is quantitative and allows dual-color imaging of two targets in the same field of view (FOV) as well as DNA co-staining. We present the first single-molecule localization microscopy (SMLM) images of the subcellular organization and dynamics of two crucial intracellular proteins in living H. volcanii cells, FtsZ1, which shows complex structures in the cell division ring, and RNA polymerase, which localizes around the periphery of the cellular DNA.This work should provide incentive to develop SMLM strategies for other archaeal organisms in the near future.