bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ALMA-PILS survey: first detection of the unsaturated 3-carbon molecules Propenal (C2H3CHO) and Propylene (C3H6) towards IRAS 16293–2422 B
Authors: Manigand S. , Coutens A. , Loison J.-C. , Wakelam V. , Calcutt H. , Müller H. S. P. , Jørgensen J. K. , Taquet V. , Wampfler S. F. , Bourke T. L. , Kulterer B. M. , van Dishoeck E. F. , Drozdovskaya M. N. , Ligterink N. F. W. 
Published: July 2020

Context.Complex organic molecules with three carbon atoms are found in the earliest stages of star formation. In particular, propenal (C2H3CHO) is a species of interest due to its implication in the formation of more complex species and even biotic molecules.Aims.This study aims to search for the presence of C2H3CHO and other three-carbon species such as propylene (C3H6) in the hot corino region of the low-mass protostellar binary IRAS 16293–2422 to understand their formation pathways.Methods.We use ALMA observations in Band 6 and 7 from various surveys to search for the presence of C3H6and C2H3CHO towards the protostar IRAS 16293–2422 B (IRAS 16293B). The identification of the species and the estimates of the column densities and excitation temperatures are carried out by modeling the observed spectrum under the assumption of local thermodynamical equilibrium.Results.We report the detection of both C3H6and C2H3CHO towards IRAS 16293B, however, no unblended lines were found towards the other component of the binary system, IRAS 16293A. We derive column density upper limits for C3H8, HCCCHO,n-C3H7OH,i-C3H7OH, C3O, and cis-HC(O)CHO towards IRAS 16293B. We then use a three-phase chemical model to simulate the formation of these species in a typical prestellar environment followed by its hydrodynamical collapse until the birth of the central protostar. Different formation paths, such as successive hydrogenation and radical-radical additions on grain surfaces, are tested and compared to the observational results in a number of different simulations, to assess which are the dominant formation mechanisms in the most embedded region of the protostar.Conclusions.The simulations reproduce the abundances within one order of magnitude from those observed towards IRAS 16293B, with the best agreement found for a rate of 10−12cm3s−1for the gas-phase reaction C3+ O → C2+ CO. Successive hydrogenations of C3, HC(O)CHO, and CH3OCHO on grain surfaces are a major and crucial formation route of complex organics molecules, whereas both successive hydrogenation pathways and radical-radical addition reactions contribute to the formation of C2H5CHO.
RAPTOR
Authors: Bronzwaer T. , Younsi Z. , Davelaar J. , Falcke H. 
Published: July 2020

Context. Accreting supermassive black holes are sources of polarized radiation that propagates through highly curved spacetime before reaching the observer. Accurate and efficient numerical schemes for polarized radiative transfer in curved spacetime are needed to help interpret observations of such polarized emission.
Aims. We aim to extend our publicly available radiative transfer code RAPTOR to include polarized radiative transfer, so that it can produce simulated polarized observations of accreting black holes. The RAPTOR code must remain compatible with arbitrary spacetimes and it must be efficient in operation, despite the added complexity of polarized radiative transfer.
Methods. We provide a brief review of various codes and methods for covariant polarized radiative transfer available in the literature and existing codes, and we present an efficient new scheme. For the spacetime propagation aspect of the computation, we developed a compact, Lorentz-invariant representation of a polarized ray. For the plasma-propagation aspect of the computation, we performed a formal analysis of the stiffness of the polarized radiative-transfer equation with respect to our explicit integrator. We also developed a hybrid integration scheme that switches to an implicit integrator in case of stiffness in order to solve the equation with optimal speed and accuracy for all possible values of the local optical/Faraday thickness of the plasma.
Results. We performed a comprehensive code verification by solving a number of well-known test problems using RAPTOR and comparing its output to exact solutions. We also demonstrate convergence with existing polarized radiative-transfer codes in the context of complex astrophysical problems, where we found that the integrated flux densities for all Stokes parameters converged to excellent agreement.
Conclusions. The RAPTOR code is capable of performing polarized radiative transfer in arbitrary, highly curved spacetimes. This capability is crucial for interpreting polarized observations of accreting black holes, which can yield information about the magnetic-field configuration in such accretion flows. The efficient formalism implemented in RAPTOR is computationally light and conceptually simple. The code is publicly available.
Übersicht über die bisher publizierten gastroenterologischen Empfehlungen der „Klug entscheiden“-Initiative
Authors: van Leeuwen Pia 
Published: July 2020

ZusamMenfassungDieses Kapitel zeigt eine Übersicht über alle im Rahmen der Initiative „Klug entscheiden“ bisher publizierten gastroenterologischen Klug entscheiden-Empfehlungen.
Rekanalisierung durch Sondierung mit Oggel-Sonden-Implantation bei erworbener Tränenwegsstenose
Authors: Baier Markus Arthur , Mikielewicz Marek , Lang Gerhard K. , Kampmeier Jürgen 
Published: July 2020

ZusammenfassungHintergrund Die Rekanalisierung und bikanalikuläre Schienung der Tränenwege mit Silikonschlauch stellt bei erworbenen Tränenwegsstenosen eine Therapieoption dar, nach der häufig Restenosierungen beobachtet werden. Ziel war die Analyse des Therapieerfolges der Oggel-Sonden-Implantation nach Tränenwegsspülung und -sondierung, Erfassung weiterer Beschwerdemerkmale sowie ein Literaturvergleich.Patienten/Material und Methodik Die retrospektive Datenerhebung erfolgte mithilfe von Patientenakten sowie Fragebogen an Patienten und deren behandelnde Augenfachärzte, in denen die subjektive Beschwerdefreiheit sowie weitere Beschwerdemerkmale zu 3 Zeitpunkten nach Oggel-Sonden-Explantation eruiert wurden: unmittelbar, nach 1 Monat und 1 Jahr. Eingeschlossen wurden 82 durchgeführte Eingriffe an der Augenklinik des Universitätsklinikums Ulm zwischen 2006 und 2015. Der Einfluss von Risikofaktoren auf den Therapieerfolg wurde statistisch mittels logistischer Regressionsanalyse und Mann-Whitney-U-Test bestimmt. Ein Untergruppenvergleich wurde mit dem Pearson-Chi-Quadrat-Test und dem Exakten Fisher-Test auf signifikante Unterschiede sowie mit einer Kaplan-Meier-Analyse determiniert.Ergebnisse Direkt nach Oggel-Sonden-Explantation lag die Beschwerdefreiheit bei 80,8%, nach 1 Monat sank sie auf 61,6% und nach 1 Jahr betrug sie 42,5% im Patientenkollektiv (n = 82). Es zeigten sich keine signifikanten Unterschiede bez. Stenoselokalisation, Patientenalter oder Geschlecht. Ebenso konnte kein signifikanter Einfluss des Patientenalters, der präoperativen Beschwerdedauer sowie von Risikofaktoren, die für Tränenwegsstenosen prädisponieren, nachgewiesen werden. Eine Kaplan-Meier-Analyse lieferte für den Zeitraum eines Jahres eine Wahrscheinlichkeit der Beschwerdefreiheit von 52,2% für das Patientenkollektiv sowie eine mittlere Dauer der Beschwerdefreiheit von 34,2 Wochen.Schlussfolgerung Die Ergebnisse ermöglichen eine prognostische Einschätzung des Therapieerfolges bei fehlenden signifikanten Unterschieden in den Untergruppen. Der Therapieerfolg nach Oggel-Sonden-Implantation lag im unteren Drittel vergleichbarer Studien. Die Ergebnisse des zeitlich progredient abnehmenden Therapieerfolges bestätigen die Beobachtungen anderer Studien. Der Literaturvergleich gestaltete sich methodisch erschwert aufgrund abweichender Studienmerkmale, für zukünftige Studien wäre eine Vereinheitlichung sinnvoll.
Heimweh – eine systematische Übersicht zum Vorkommen und den Folgen eines Phänomens von aktueller Relevanz
Authors: Beschoner Petra , Sosic-Vasic Zrinka , Jerg-Bretzke Lucia 
Published: July 2020

Zusammenfassung
Einleitung Heimweh ist ein Phänomen vieler Kulturen. Die internationale Forschung beschäftigt sich mit diesem Thema, nicht so in Deutschland. Ziel dieser Arbeit ist, das Phänomen Heimweh dem Leser aus wissenschaftlicher und psychiatrischer Sicht näherzubringen, Evidenz zu vermitteln und ein Bewusstsein für die Aktualität zu schaffen.
Methodik Systematische Literaturrecherche in den Datenbanken „Psyndex“, „Pubmed“ und „google scholar“.
Ergebnisse Die Angaben zur Häufigkeit schwanken in unterschiedlichen Populationen von 20–90 %, was v. a. an uneinheitlichen Definitionen von Heimweh und den unterschiedlichen Messinstrumenten liegt. Die klinischen Folgen reichen von Schlafstörungen über Depressivität bis hin zu sozialen Auffälligkeiten.
Schlussfolgerung Migrationsbewegungen, steigende Prävalenz psychischer Erkrankungen und aus Heimweh resultierende Beeinträchtigungen machen deutlich, wie wichtig ein modernes Verständnis von Heimweh ist.
The S2-Alar-Iliac Screw for Pelvic Trauma
Authors: Hartensuer Rene , Grüneweller Niklas , Lodde Moritz Friedrich , Evers Julia , Riesenbeck Oliver , Raschke Michael 
Published: July 2020

AbstractPercutaneous sacro-iliac screw osteosynthesis is considered to be standard of care for most posterior pelvic ring fractures. However, special situations require alternative strategies for sufficient stabilization. In these cases, stabilization can often be achieved using posterior instrumentation e.g. using SIPS-screws (spina-iliaca-posterior-superior screws). However, this often leads to implant-related aggravation of the sometimes already critical soft tissue conditions after pelvic trauma. S2-Ala-Ilium screws (S2AI screws) are a suitable alternative. The starting point lies medial of the posterior superior iliac spine below the iliac level. It is almost in line with a potential spinal instrumentation and therefore usually causes fewer soft tissue problems. Although this technique has been widely used in spinal surgery in recent years, its use in orthopaedic traumatology is largely unknown. The possibilities but also the limitations of this technique for the treatment
of injuries to the pelvis are illustrated by this retrospective case series.
Fragility Fractures of the Pelvic Ring – Does the Evidence of Oedema Lead us to More Surgeries?
Authors: Lang Patricia , Sterneder Manuel , Riesner Hans-Joachim , Hackenbroch Carsten , Friemert Benedikt , Palm Hans-Georg 
Published: July 2020

Abstract
Introduction The choice of therapy for fragility fractures of the pelvis (FFP) is largely determined by the diagnosed fracture morphology. It is now unclear whether the change in diagnostic options – sensitive detection of fracture oedema in the sacrum using MRI and dual-energy computed tomography (DECT) – has an impact on the therapeutic consequences. The aim of this retrospective study was therefore to evaluate the change in the diagnostics used and the resulting therapy regimen in our patient population.
Materials and Methods We performed a monocentric-retrospective analysis of 196 patients with a fragility fracture of the pelvis in our clinic (national TraumaZentrum® DGU and SAV approval) in the period from 2008 to 2017. We examined changes in epidemiology, diagnostics/classification and therapy of the pelvic ring fractures treated by us.
Results The diagnostic procedures used are subject to a clear change towards oedema detection using MRI and DECT. The graduation has changed towards more severe forms of fracture after FFP. There is now also an increasing proportion of patients treated by surgery (2008 – 2009: 5.3% vs. 2015 – 2017: 60.3%).
Conclusion We were able to show that the introduction of sensitive diagnostic procedures coincided with a higher classification of the fractures. It is also noteworthy that the increase in operations is not only due to a higher degree of classification; also in relative terms, more patients are operated on within type FFP II.
Flipped Ophthalmology Classroom: A Better Way to Teach Medical Students
Authors: Diel Ryan J. , Avdic Armin , Kemp Pavlina S. 
Published: July 2020

Abstract
Objective While medical education has generally progressed, advancements in ophthalmic education have been minimal. The flipped classroom technique is a research-supported approach to adult learning that encourages active participation. The effectiveness of widely implementing the flipped classroom modality in ophthalmology had not been studied. The purpose of this study was to evaluate a flipped classroom, primary care-focused curriculum for medical students in their ophthalmology clerkship.
Methods The ophthalmology clerkship curriculum was changed from a traditional, diagnosis-focused, lecture-based system to a chief complaint-based, flipped classroom structure. The study was performed over a 3-year period from 2016 (full traditional lecture-based system) to 2018 (full flipped classroom structure). Medical students' evaluations of the clerkship, recorded lecture viewership, and exam scores were retrospectively reviewed. Cohorts from study years 2016 and 2018 were used to assess knowledge acquisition and the attitudes of learners after implementing a flipped classroom structure.
Results The primary care-focused, flipped classroom received a higher clerkship rating than the diagnosis-based traditional classroom (mean 4.18 vs. 3.82, respectively, p = 0.008). Students of the flipped classroom modality found the teaching sessions more valuable, experienced more direct interaction with faculty and residents, regarded the faculty and residents as excellent teachers, and received feedback that helped them assess their individual skills and progress. These improvements were made without changing test performance while only modestly increasing hours spent studying.
Conclusion A chief complaint-based, flipped classroom approach to the basic ophthalmology clerkship increased student satisfaction, without changing the amount of knowledge gained. This resulted in more valuable and effective learning experiences for medical students.
Is There a Role of Meniscal Morphology in the Risk of Noncontact Anterior Cruciate Ligament Rupture? A Case–Control Study
Authors: Unal Melih , Kose Ozkan , Aktan Cemil , Gumussuyu Gurkan , May Hasan , Kati Yusuf Alper 
Published: July 2020

AbstractThe purpose of this study was to identify the anatomical risk factors and determine the role of meniscal morphology in noncontact anterior cruciate ligament (ACL) rupture. A total of 126 patients (63 with noncontact ACL rupture and 63 age- and sex-matched controls) with intact menisci were included in this retrospective case–control study. On knee magnetic resonance imaging (MRI), meniscal morphometry (anterior, corpus, and posterior heights and widths of each meniscus), tibial slope (medial and lateral separately), notch width index, roof inclination angle, anteromedial bony ridge, tibial eminence area, and Q-angle measurements were assessed. The data were analyzed using multiple regression analyses to identify independent risk factors associated with ACL rupture. Using a univariate analysis, medial and lateral menisci anterior horn heights (p < 0.001; p < 0.003), medial and lateral menisci posterior horn heights (p < 0.001; p < 0.001), lateral meniscus corpus width (p < 0.004), and notch width index (p < 0.001) were significantly higher in the control group. Lateral tibial slope (p < 0.001) and anteromedial bony ridge thickness (p < 0.001) were significantly higher in the ACL rupture group. Multivariate analysis revealed that decreased medial meniscus posterior horn height (odds ratio [OR]: 0.242; p < 0.001), increased lateral meniscus corpus width (OR: 2.118; p < 0.002), increased lateral tibial slope (OR: 1.95; p < 0.001), and decreased notch width index (OR: 0.071; p = 0.046) were independent risk factors for ACL rupture. Notch stenosis, increased lateral tibial slope, decreased medial meniscus posterior horn height, and increased lateral meniscus corpus width are independent anatomical risk factors for ACL rupture. Meniscal morphological variations also play a role in ACL injury. This is a Level III, retrospective case–control study.
Coronary Bifurcation Lesion–Management
Authors: Jyotsna Maddury 
Published: July 2020

AbstractCoronary bifurcation lesion management is challenging even in this modern era of drug-eluting stents (DES). A debate always exists as to what mode of treatment is better–one-stent or two-stent strategy. As in hospital and major adverse cardiac events (MACE) are more in the follow-up, what improvements in management strategy are required in relation to bifurcation lesions? We have more questions than answers for this type of lesion. In this article, we try to analyze these issues.
The Neurocritical Care Society of India (NCSI) and the Indian Society of Neuroanaesthesiology and Critical Care (ISNACC) Joint Position Statement and Advisory on the Practice of Neurocritical Care during the COVID-19 Pandemic
Authors: Vanamoorthy Ponniah , Singh Gyaninder P. , Bidkar Prasanna U. , Mitra Ranadhir , Sriganesh Kamath , Chavali Siddharth , Muthuchellapan Radhakrishnan , Keshavan Venkatesh H. , Anand Saurabh , Goyal Keshav , Yadav Rahul , Rath Girija P. , Srivastava Shashi 
Published: July 2020

AbstractThe COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) has rapidly spread across the world including India. Management of patients complicated with neurological illness requiring neurocritical care is challenging during this time. Patients with neurological disease may develop COVID-19 infection or there could be independent neurological manifestations of COVID-19. Critically ill neurological patients are more vulnerable to contracting SARS-CoV-2 infection. Also, neurological patients with comorbidities and multisystem involvement are at increased risk of adverse outcomes. Though SARS-CoV-2 predominantly affects the pulmonary system, it can complicate the assessment and management of neurological patients. With increasing COVID-19 numbers, the hospitalizations of both non-COVID and COVID-19 neurological patients will bring significant strain on the hospital and neurocritical care facilities. Streamlining work pattern, understanding the pathophysiology of COVID-19 and its impact on neurological function, establishing general and specific neurocritical care management strategies, ensuring protection and well-being of health care providers, and implementing effective infection control policies are key elements of efficient neurocritical care management during this pandemic. This joint position statement and advisory on the practice of neurocritical care during the COVID-19 pandemic by the Neurocritical Care Society of India and the Indian Society of Neuroanaesthesiology and Critical Care has been developed to guide clinicians providing care to the critically ill neurological patients in the neurocritical care unit during the current pandemic. As the situation from this novel disease is rapidly evolving, readers must constantly update themselves with newly emerging evidence to provide the best possible care to the critically ill neurological patients.
Mesenchymal stromal cell‐derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia‐induced lung injury
Authors: Willis Gareth R. , Fernandez‐Gonzalez Angeles , Reis Monica , Yeung Vincent , Liu Xianlan , Ericsson Maria , Andrews Nick A. , Mitsialis S. Alex , Kourembanas Stella 
Published: July 2020

ABSTRACTEarly administration of mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (MEx) has shown considerable promise in experimental models of bronchopulmonary dysplasia (BPD). However, the ability of MEx to reverse the long‐term pulmonary complications associated with established BPD remains unknown. In this study, MEx were isolated from media conditioned by human Wharton's Jelly‐derived MSC cultures. Newborn mice (FVB strain) were exposed to hyperoxia (HYRX (75% O2)) before returning to room air at postnatal day 14 (PN14). Following prolonged HYRX‐exposure, animals received a single MEx dose at PN18 or serial MEx treatments at PN18‐39 (“late” intervention). This group was compared to animals that received an early single MEx dose at PN4 (“early” intervention). Animals were harvested at PN28 or 60 for assessment of pulmonary parameters. We found that early and late MEx interventions effectively ameliorated core features of HYRX‐induced neonatal lung injury, improving alveolar simplification, pulmonary fibrosis, vascular remodelling and blood vessel loss. Exercise capacity testing and assessment of pulmonary hypertension (PH) showed functional improvements following both early and late MEx interventions. In conclusion, delivery of MEx following prolonged HYRX‐exposure improves core features of experimental BPD, restoring lung architecture, decreasing pulmonary fibrosis and vascular muscularization, ameliorating PH and improving exercise capacity. Taken together, delivery of MEx may not only be effective in the immediate neonatal period to prevent the development of BPD but may provide beneficial effects for the management and potentially the reversal of cardiorespiratory complications in infants and children with established BPD.
Characterisation of Au surface properties relevant for UV photoemission-based charge control for space inertial sensors
Authors: Olatunde Taiwo , Apple Stephen , Inchauspé Henri , Parry Samantha , Letson Benjamin , Wass Peter J , Mueller Guido , Conklin John W 
Published: July 2020

Abstract
Precision space inertial sensors used for satellite geodesy missions, tests of fundamental physics, and gravitational wave observation utilise UV photoemission to control the electric potential of free-falling test masses with respect to their surrounding electrode housings. Successful generation of photoelectrons requires UV light energies greater than the work function of the illuminated surface. To ensure bi-polar test mass charge control (positive and negative charge rates), the quantum yields of the test mass and electrode housing surfaces must be well-balanced. LISA Pathfinder used mercury vapour lamps at 254 nm to discharge the gold coated test mass by likely relying on contaminants to lower the work function of gold from its nominal value of 5.2 eV. The LISA gravitational wave mission plans to use UV light emitting diodes (LEDs) instead of mercury vapour lamps. These UV LEDs have a lower mass, higher power efficiency, and produce light at wavelengths below 240 nm. In this paper, we measure the quantum yields of several Au-coated surfaces over a range of UV wavelengths and environmental conditions, varying temperature, vacuum pressure, and measuring over long periods of time. We use these data to draw conclusions and make recommendations for the development and handling of precision space inertial sensors for LISA and for other missions in the future.
Comprehensive model and performance optimization of phase-only spatial light modulators
Authors: A Pushkina A , I Costa-Filho J , Maltese G , I Lvovsky A 
Published: July 2020

Abstract
Several spurious effects are known to degrade the performance of phase-only spatial light modulators. We introduce a comprehensive model that takes into account the major ones: curvature of the back panel, pixel crosstalk and the internal Fabry–Perot cavity. To estimate the model parameters with high accuracy, we generate blazed grating patterns and acquire the intensity response curves of the first and second diffraction orders. The quantitative model is used to generate compensating holograms, which can produce optical modes with high fidelity.