bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Metadata Describing Topographic Maps in a National Library
Authors: Kuzma Marta , Moscicka Albina 
Published: October 2020

Abstract
Nowadays, map users come from a diverse disciplines and use maps for different purposes, but they all are confronted with the same task: finding the maps they need. Searching systems, used by museums or archives collecting maps, rely on metadata. However, the scope and method of saving map data in metadata are not often connected with the way in which users search for maps and therefore they are often unable to find the maps necessary for their research. Moreover, the ways of describing maps in metadata are different in each institution, what hinders the interoperability and wide using of data. In this context, the key questions are: what scope of metadata can provide a proper description of maps and how to evaluate if metadata from concerned institution fulfill these needs and give user the chance to find necessary maps. Therefore, the aim of our research was to evaluate topographic maps metadata in the context of the possibility to evaluate their usability of specific users’ needs in the National Library of Poland (NLP. The area of interest are topographic maps because they are the most heavily used for research and other purposes. To assess metadata for the purposes of evaluating the usability of topographic maps, a two-stage procedure was used. It covers the evaluation of topographic maps metadata, followed by their assessment in terms of whether maps found on their basis might be useful in our research. The research was carried out on 35,092 topographic maps issued in the years 1608-2017, in scales ranging from 1:10,000 to 1:500,000 from the National Library of Poland. These maps mainly cover the current territories of Poland, Belarus, Germany, Ukraine, Czech Republic, Lithuania, and Russia. The conducted analysis of topographic maps in the National Library of Poland revealed that the collected data are very interesting and match the users’ needs.
Periodic injections of adipose-derived stem cell sheets attenuate osteoarthritis progression in an experimental rabbit model
Authors: Takagi Tomoharu , Kabata Tamon , Hayashi Katsuhiro , Fang Xiang , Kajino Yoshitomo , Inoue Daisuke , Ohmori Takaaki , Ueno Takuro , Yoshitani Junya , Ueoka Ken , Yamamuro Yuki , Tsuchiya Hiroyuki 
Published: October 2020

Abstract
Background: Subcutaneous adipose tissue represents an abundant source of multipotent adult stem cells named as Adipose-derived stem cells (ADSCs). With a cell sheet approach, ADSCs survive longer, and can be delivered in large quantities. We investigated whether intra-articular ADSC sheets attenuated osteoarthritis (OA) progression in a rabbit anterior cruciate ligament transection (ACLT) model.Methods: Fabricating medium containing ascorbate-2-phosphate was used to enhance collagen protein secretion by the ADSCs to make ADSC sheets. At 4 weeks after ACLT, autologous ADSC sheets were injected intra-articularly into the right knee (ADSC sheets group), and autologous cell death sheets treated by liquid nitrogen were injected into the left knee (control group). Subsequent injections were administered once weekly. Femoral condyles were compared macroscopically and histologically.Results: Macroscopically, OA progression was significantly milder in the ADSC sheets than in the control groups. Histologically, control knees showed obvious erosions in the medial and lateral condyles, while cartilage was retained predominantly in the ADSC sheets group. Immunohistochemically, MMP-1, MMP-13, ADAMTS-4 were less expressive in the ADSC sheets than in the control groups.Conclusions: Periodic ADSC sheets injections inhibited articular cartilage degeneration without inducing any adverse effects. A large quantity of autologous ADSCs delivered by cell sheets homed to the synovium and protected chondrocytes.
Risk areas for tuberculosis among children and their inequalities in a city from Southeast Brazil.
Authors: Alves Yan Mathias , Berra Thais Zamboni , Alves Luana Seles , de Assis Ivaneliza Simionato , Arcoverde Marcos Augusto Moraes , Ramos Antônio Carlos Vieira , Arroyo Luiz Henrique , Campoy Laura Terenciani , Bruce Alexandre Tadashi Inomata , Santos Felipe Lima dos , Souza Ludmilla Leidianne Limírio , Crispim Juliane de Almeida , Arcêncio Ricardo Alexandre 
Published: October 2020

Abstract
BACKGROUND

The objective of the study was to identify areas of risk for the appearance of tuberculosis in children and their association with social inequalities in a municipality in southeastern Brazil.

METHODS

Ecological study conducted in Ribeirão Preto, Brazil. To identify areas of spatial risk for tuberculosis in children, we used spatial scanning statistics. To analyze the association of cases of childhood tuberculosis with social vulnerability, we used the Social Vulnerability Index of São Paulo, and four explanatory statistical models were listed.

RESULTS

There were 96 cases of childhood tuberculosis, of which 90 were geocoded through a process of converting addresses to geographic coordinates. A risk area was identified in the municipality, where children under 15 years old have 3.14 times greater risk of contracting tuberculosis than those living outside this area. The variables identified as risk factors were: number of private and collective households, proportion of children aged 0 to 5 years in the population, proportion of households without per capita income, and the proportion of private households with monthly nominal incomes of up to one quarter of wage minimums. The variables identified as protection factors were the proportion of women under the age of 30 years responsible for the household under and women responsible for the household with an average income over BRL 2,344.

CONCLUSION

The study showed areas of risk for the occurrence of tuberculosis in children. The study is in line with the End TB Strategy and the 2030 Agenda, which aim to support strategic actions and, therefore, save the lives of children through the systematic, intensified, and comprehensive identification of children with tuberculosis respiratory symptoms in the community.
Differences between encoding and retrieval failure in mild cognitive impairment: results from quantitative electroencephalography and magnetic resonance volumetry
Authors: Han Su-Hyun , Pyun Jungmin , Yeo Soeun , Kang Dong Won , Jeong Ho Tae , Kang Seung Wan , Kim SangYun , Youn Young Chul 
Published: October 2020

Abstract
Background: The memory impairments in mild cognitive impairment (MCI) can be classified into encoding (EF) and retrieval (RF) failure, which can be affected by underlying pathomechanism. We explored the differences structurally and functionally.Methods: We compared quantitative electroencephalography (qEEG) power spectra and connectivity between 87 MCI patients with EF and 78 MCI with RF using iSyncBrain ™ (iMediSync, Inc., Korea) (https://isyncbrain.com/). Voxel-based morphometric analysis of the gray matter (GM) in the MCI groups and 71 cognitive normal controls were also done using the Computational Anatomy Toolbox 12 (http://www.neuro.uni-jena.de/cat/).Results: qEEG showed higher frontal theta and lower beta2 band power, and higher theta connectivity in the EF. There was no statistically significant difference in GM volume between the EF and RF. However, when compared to normal control, GM volume reductions due to EF in the left thalamus and bilateral hippocampi and reductions due to RF in the left thalamus, right superior frontal lobe, right superior temporal lobe, and right middle cingulum were observed ( p < 0.05, family-wise error correction).Conclusions: MCI differs functionally and structurally according to their specific memory impairments. The EF findings are structurally and functionally more consistent with the prodromal Alzheimer's disease stage than the RF findings. Since this study is a cross-sectional study, prospective follow-up studies are needed to investigate whether different types of memory impairments can predict the underlying pathology of amnestic MCI. Additionally, insufficient sample size may lead to ambiguous statistical findings in direct comparisons, a larger patient cohort could more robustly identify differences in GM volume reductions between the EF and the RF group.
A retrospective case series of Fournier’s gangrene: necrotizing fasciitis in perineum and perianal region
Authors: Zhang Nan , Yu Xin , Zhang Kai , Liu Tongjun 
Published: October 2020

Abstract
Background To describe the clinical characteristics and management for Fournier’s gangrene. Experience summary and literature references are provided for future treatment improvement. Methods We retrospectively reviewed the cases diagnosed with Fournier’s gangrene in our department from June 2016 to June 2019. Clinical data, including manifestation, diagnosis, treatment and outcomes for Fournier’s gangrene were presented.Results There were 12 patients enrolled in this paper, with the average age of 60 years old. It showed a male predominance with male-to-female ratio of 6:1. The average of laboratory risk indicator for necrotizing fasciitis (LRINEC) score was 10.1. Diabetes mellitus was the main predisposing disease. 11 patients received emergency debridement and 1 patient died of sepsis on the 2nd day after admission. The mortality rate was 8.3%. 6 cases developed complications, including sepsis, pneumonia, renal and heart failure. Negative pressure wound therapy (NPWT) was applied in 10 cases, while the rest 1 received normal daily dressing changes because of fecal contamination. Flaps were utilized in 2 patients to cover the defect, including one with advancement flap and one with pudendal-thigh flap, while others received secondary suture, secondary healing, skin graft or combined management. No relapse was observed during the follow-up visits.Conclusions Fournier’s gangrene is a life-threatening infection that requires early diagnosis and surgery intervention. The predisposing disease, clinical manifestation and LRINEC score should be taken into comprehensive consideration, which is helpful for timely diagnosis. Moreover, further successful treatment depends on the aggressive debridement, broad-spectrum antibiotics therapy, wound management and closure choice.
Long-term Experience with Triheptanoin in 12 Austrian Patients with Long-chain Fatty Acid Oxidation Disorders
Authors: Zöggeler Thomas , Stock Katharina , Jörg-Streller Monika , Spenger Johannes , Konstantopoulou Vassiliki , Hufgard-Leitner Miriam , Scholl-Bürgi Sabine , Karall Daniela 
Published: October 2020

Abstract
BackgroundLong-chain fatty acid oxidation disorders (LC-FAOD) are a group of rare inborn errors of metabolism with autosomal recessive inheritance that may cause life-threatening events. Treatment with triheptanoin, a synthetic seven-carbon fatty acid triglyceride compound with an anaplerotic effect, seems beneficial, but clinical experience is limited. We report our long-term experience in an Austrian cohort of LC-FAOD patients.MethodsWe retrospectively assessed clinical outcome and total hospitalization days per year before and after start with triheptanoin by reviewing medical records of 12 Austrian LC-FAOD patientsResultsFor 12 Austrian LC-FAOD patients at three metabolic centers, triheptanoin was started shortly after birth in 3/12, and between 7.34 and 353.3 (median 44.5; mean 81.1) months of age in 9/12 patients. For 11 pediatric patients, mean duration of triheptanoin intake was 5.3 (median 3.9, range 1.2 to 15.7) years, 10/11 pediatric patients have an ongoing intake of triheptanoin. One patient quit therapy due to reported side effects. Total hospitalization days per year compared to before triheptanoin treatment decreased by 82.3% from 27.1 (range 11-65) days per year to 4.8 (range 0-13) days per year, and hospitalization days in the one year pre- compared to the one year post-triheptanoin decreased by 69.8% from 27.1 (range 4-75) days to 8.2 (range 0-25) days. All patients are in good clinical condition, show normal psychomotor development and no impairment in daily life activities.ConclusionIn this retrospective observational study in an Austrian LC-FAOD cohort, triheptanoin data show improvement in disease course. Triheptanoin appears to be a safe and beneficial treatment option in LC-FAOD. For further clarification, additional prospective randomized controlled trials are needed.
Fabrication and Performance of Atmospheric Plasma Sprayed Solid Oxide Fuel Cells with Liquid Antimony Anodes
Authors: Jiang Yidong , Mo Wenfei , Cao Tianyu , Shi Yixiang , Cai Ningsheng 
Published: October 2020

Abstract
A Solid oxide fuel cell (SOFC) with a liquid antimony anode (LAA) is a potential energy conversion technology for impurity-containing fuels. Atmospheric plasma spraying (APS) technology has become a promising LAA-SOFC preparation method because of its economy and convenience. In this paper, button SOFCs with different cathode materials and ratios of pore former were prepared by the APS method and measured at 750°C. The effect of the cathode structure on the electrochemical performance of the LAA-SOFCs was analyzed, and an optimized spraying method for LAA-SOFCs was developed. A tubular LAA-SOFC was prepared by the APS method based on the optimized spraying method and a peak power of 2.5 W was reached. The tubular cell was also measured at a constant current of 2 A for 20 hours and fed with a sulfur-containing fuel to demonstrate its impurity resistance and electrode stability.
Metabolomics analysis reveals Embden Meyerhof Parnas pathway activation and flavonoids accumulation during dormancy transition in tree peony
Authors: Zhang Tao , Yuan Yanchao , Zhan Yu , Cao Xinzhe , Liu Chunying , Zhang Yuxi , Gai Shupeng 
Published: October 2020

Abstract
Background: Bud dormancy is a sophisticated strategy which plants evolve to survive in tough environments. Endodormancy is a key obstacle for anti-season culture of tree peony, and sufficient chilling exposure is an effective method to promote dormancy release in perennial plants including tree peony. However, the mechanism of dormancy release is still poorly understood, and there are few systematic studies on the metabolomics during chilling induced dormancy transition.Results: The tree peony buds were treated with artificial chilling, and the metabolmics analysis was employed at five time points after 0-4ºC treatment for 0, 7, 14, 21 and 28 d, respectively. A total of 535 metabolites were obtained and devided into 11 groups including flavonoids, amino acid and its derivatives, lipids, organic acids and its derivates, nucleotide and its derivates, alkaloids, hydroxycinnamoyl derivatives, carbohydrates and alcohols, phytohormones, coumarins and vitamins. Totally, 118 differential metabolites (VIP≥1, P<0.05) during chilling treatment process were detected, and their KEGG pathways involved in several metabolic pathways related to dormancy. Sucrose was the most abundant carbohydrate in peony bud. Starch was degradation and Embden Meyerhof Parnas (EMP) activity were increased during the dormancy release process, according to the variations of sugar contents, related enzyme activities and key genes expression. Flavonoids synthesis and accumulation were also promoted by prolonged chilling. Moreover, the variations of phytohormones (salicylic acid, jasmonic acid, abscisic acid, and indole-3-acetic acid) indicated they played different roles in dormancy transition.Conclusion: Our study suggested that starch degradation, EMP activation, and flavonoids accumulation were crucial and associated with bud dormancy transition in tree peony.
Adoption of water harvesting technologies among agro-pastoralists in semi-arid rangelands of South Eastern Kenya
Authors: Lutta Alphayo , Wasonga Oliver Vivian , Nyangito Moses , Sudan Falendra Kumar , Robinson Lance 
Published: October 2020

Abstract
Background: The arid and semi-arid lands experience inherently unpredictable rainfall and frequent droughts, which are exacerbated by climate change. This consequently leads to deterioration of land resources, and eventually forage and water shortages that negatively impact livestock productivity. In Kenya, development and governments agencies have been supporting on farm adaptation strategies such as water harvesting conservation structures to cope with climate hazards that affect agricultural production and food security in agro-pastoral and pastoral systems. The various water harvesting structures that have been promoted include Zai pits for growing crops and trees, water pans and shallow wells for livestock and domestic use, as well as irrigation. However, the impact of such interventions with regard to improvement of range productivity and therefore welfare of agro-pastoral and pastoral communities has not been felt owing to low adoption rate by households. Results: This study determined social, economic and institutional factors influencing the adoption of water harvesting technologies by households in pastoral areas of Tana river County of Kenya. The data was collected through household survey, focus group discussions and key informant interviews. The results show that access to extension services and training, level of monthly income, main source of livelihood, land tenure, membership in social groups and availability of active farm labor significantly influenced the adoption of water harvesting structures. Conclusion: Pastoralists therefore need to be mobilized and trained on how to construct and use water harvesting structures and sensitized on the potential socioeconomic benefits of adopting them. Key words: Drylands, Water harvesting, Adaptive strategies, Pastoralism
Ovarian Cancer Cells Direct Monocyte Differentiation Through A Non-Canonical Pathway
Authors: Fogg Kaitlin C. , Miller Andrew E. , Li Ying , Flanigan Will , Walker Alyssa , O’Shea Andrea , Kendziorski Christina , Kreeger Pamela 
Published: October 2020

Abstract
Background: Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are correlated with poor HGSOC survival rates, and AAMs increase the attachment and spread of HGSOC cells in vitro. However, the mechanism by which monocytes in the HGSOC tumor microenvironment are differentiated and polarized to AAMs remains unknown. Methods: Using an in vitro co-culture device, we cultured naïve, primary human monocytes with a panel of five HGSOC cell lines over the course of seven days. An empirical Bayesian statistical method, EBSeq, was used to couple RNA-seq with observed monocyte-derived cell phenotype to explore which HGSOC-derived soluble factors supported differentiation to CD68+ macrophages and subsequent polarization towards CD163+ AAMs. Pathways of interest were interrogated using small molecule inhibitors, neutralizing antibodies, and CRISPR knockout cell lines.Results: HGSOC cell lines displayed a wide range of abilities to generate AAMs from naïve monocytes. Much of this variation appeared to result from differential ability to generate CD68+ macrophages, as most CD68+ cells were also CD163+. Differences in tumor cell potential to generate macrophages was not due to a MCSF-dependent mechanism, nor variance in established pro-AAM factors. TGFa was implicated as a potential signaling molecule produced by tumor cells that could induce macrophage differentiation, which was validated using a CRISPR knockout of TGFA in the OVCAR5 cell line.Conclusions: HGSOC production of TGFa drives monocytes to differentiate into macrophages, representing a central arm of the mechanism by which AAMs are generated in the tumor microenvironment.
Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD
Authors: Cacciamani Federica , Sambati Luisa , Houot Marion , Habert Marie-Odile , Dubois Bruno , Epelbaum Stephane 
Published: October 2020

Abstract
Background: Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer's disease (AD). Recent studies showed that ACD can also be reduced in the early stages.Methods: We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution, and the association between longitudinal changes in ACD and in cognitive score.Results: 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD, and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores’ evolution, and no association between longitudinal changes in ACD and in cognitive scores. Conclusions: ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterised. Trial registration: The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42
Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species&nbsp;Anopheles gambiae&nbsp;s.s. and&nbsp;Anopheles&nbsp;coluzzii
Authors: AKPODIETE NWAMAKA OLUCHUKWU , TRIPET FREDERIC 
Published: October 2020

Abstract
Background The sibling species of the malaria mosquito, Anopheles gambiae s.s and Anopheles coluzzii co-exist in many parts of West Africa and are thought to have recently diverged through a process of ecological speciation with gene flow. Divergent larval ecological adaptations, resulting in Genotype × Environment interactions have been proposed as important drivers of speciation in these species. In West Africa, An. coluzzii tends to be associated with permanent man-made larval habitats such as irrigated rice fields which are typically more eutrophic and mineral and ammonia-rich than the temporary rain pools exploited by An. gambiae s.s. Methods To highlight G×E interactions at the larval stage and their possible role in ecological speciation of these species, we first investigated the effect of exposure to ammonium hydroxide and water mineralisation on larval developmental success. Mosquito larvae were exposed to two water sources and increasing ammonia concentrations in small containers until adult emergence. In a second experiment, larval developmental success was compared across 2 contrasted microcosms to highlight G × E interactions under conditions like those found in the natural environment. Results The first experiment revealed significant G × E interactions in developmental success and phenotypic quality for both species in response to increasing ammonia concentrations and water mineralisation. The An. coluzzii strain outperformed the An. gambiae s.s. strain under limited conditions that were closer to more eutrophic habitats. The second experiment revealed divergent crisscrossing reaction norms in the developmental success of the sibling species in the two contrasted larval environments. As expected, An. coluzzii had higher emergence rates in the rice paddy environment with emerging adults of superior phenotypic quality compared to An. gambiae s.s, and vice versa in the rain puddle environment. Conclusions Evidence for such G x E interactions lends support to the hypothesis that divergent larval adaptations to the environmental conditions found in man-made habitats such as rice-fields in An. coluzzii may have been an important driver of its ecological speciation.