bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the interactions of a Tb(III)–quercetin complex with serum albumins (HSA and BSA): spectroscopic and molecular docking studies
Authors: Shaghaghi Masoomeh , Rashtbari Samaneh , Vejdani Samira , Dehghan Gholamreza , Jouyban Abolghasem , Yekta Reza 
Published: December 2019

AbstractSerum albumins (human serum albumin (HSA) and bovine serum albumin (BSA), two main circulatory proteins), are globular and monomeric macromolecules in plasma that transport many drugs and compounds. In the present study, we investigated the interactions of the Tb(III)–quercetin (Tb–QUE) complex with HSA and BSA using common spectroscopic techniques and a molecular docking study. Fluorescence data revealed that the inherent fluorescence emission of HSA and BSA was markedly quenched by the Tb–QUE complex through a static quenching mechanism, confirming stable complex formation (a ground‐state association) between albumins and Tb–QUE. Binding and thermodynamic parameters were obtained from the fluorescence spectra and the related equations at different temperatures under biological conditions. The binding constants (Kb) were calculated to be 0.8547 × 103 M−1 for HSA and 0.1363 × 103 M−1 for BSA at 298 K. Also, the number of binding sites (n) of the HSA/BSA–Tb–QUE systems was obtained to be approximately 1. Thermodynamic data calculations along with molecular docking results indicated that electrostatic interactions have a main role in the binding process of the Tb–QUE complex with HSA/BSA. Furthermore, molecular docking outputs revealed that the Tb–QUE complex has high affinity to bind to subdomain IIA of HSA and BSA. Binding distances (r) between HSA–Tb–QUE and BSA–Tb–QUE systems were also calculated using the Forster (fluorescence resonance energy transfer) method. It is expected that this study will provide a pathway for designing new compounds with multiple beneficial effects on human health from the phenolic compounds family such as the Tb–QUE complex.
Deciphering binding mechanism between bovine serum albumin and new pyrazoline compound K4
Authors: Bozkurt Ebru , Gul Halise Inci 
Published: December 2019

AbstractThe binding mechanism of a new and possible drug candidate pyrazoline derivative compound K4 and bovine serum albumin (BSA) was investigated in buffer solution (pH 7.4) using ultraviolet–visible light absorption and steady‐state and synchronous fluorescence techniques. The fluorescence intensity of BSA was quenched in the presence of K4. The quenching process between BSA and K4 was examined at four different temperatures. Decrease of the quenching constants calculated using the Stern–Volmer equation and at increasing temperature suggested that the interaction BSA–K4 was realized through a static quenching mechanism. Synchronous fluorescence measurements suggested that K4 bounded to BSA at the tryptophan region. Fourier transform infrared spectroscopy results showed that there was no significant change in polarity around the tryptophan residue The forces responsible for the BSA–K4 interaction were examined using thermodynamic parameters. In this study, the calculated negative value of ΔG, the negative value of ΔH and the positive value of ΔS pointed to the interaction being through spontaneous and electrostatic interactions that were dominant for our cases. This study provides a very useful in vitro model to researchers by mimicking in vivo conditions to estimate interactions between a possible drug candidate or a drug and body proteins.
Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1‐Nrf2 signaling pathway
Authors: Wang Gaoyuan , Xie Xinxin , Yuan lingli , Qiu Jie , Duan Wenchao , Xu Bin , Chen Xiaoyu 
Published: December 2019

AbstractThe present study was designed to explore the biological role of resveratrol (RES) in rheumatoid arthritis (RA) and the underlying mechanism. The adjuvant‐induced arthritic rats were administered RES on the 12th day after model establishment, and then arthritis assessment, oxidative stress measurement, histological examination, and immunohistochemical staining were performed. The primary rat fibroblast‐like synoviocytes (FLS) were isolated and treated with RES in vitro and then cell proliferation and apoptosis assay were examined. Chromatin immunoprecipitation assay, luciferase reporter assay, intracellular reactive oxygen species (ROS) determination, western blot, and quantitative real time‐polymerase chain reaction (qRT‐PCR) were performed to investigate the mechanisms. RES administration decreased arthritis scores and serum levels of antioxidant enzymes, attenuated paw swelling, synovial hyperplasia, inflammatory cell infiltration, and cartilage degradation, as well as inhibited synoviocyte proliferation in synovial tissues. Further investigation indicated that RES inhibited ROS production and FLS proliferation through activating the silent information regulator 1 (SIRT1)/nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling pathway. NF‐κB was confirmed to negatively regulate miR‐29a‐3p and miR‐23a‐3p expression by directly binding to its promoter. Mechanistic analyses further revealed that Kelch‐like erythroid cell‐derived protein with CNC homology (ECH)‐associated protein 1 (Keap1), a negative regulator of Nrf2, was a downstream target of miR‐29a‐3p, while miR‐23a‐3p directly targeted cullin3 (cul3), a master regulator of ubiquitination and degradation of Nrf2. Together, the present study provided evidence that RES ameliorated RA through activation of Nrf2‐ARE signaling pathway via SIRT1/NF‐κB/miR‐29a‐3p/Keap1 and SIRT1/NF‐κB/miR‐23a‐3p/cul3 signaling pathway.
Distal nerve transfer for thenar palsy: A cadaveric study
Authors: Abou‐Al‐Shaar Hussam , Dorius Geoffrey T. , Morton David A. , Mahan Mark A. 
Published: December 2019

AbstractIntroductionSevere proximal median nerve palsies often result in irreversible thenar atrophy and thumb abduction function loss. Tendon transfer involves substantial limitations and challenges; but, distal nerve transfer may provide an alternative treatment. Our goal was to validate the anatomical suitability of two distal ulnar nerve branches for thenar muscle reanimation.Materials and MethodsWe assessed nerve transfer to the recurrent branch of median nerve (RMN) in 16 embalmed cadaveric hands. The ulnar motor branch to the flexor digiti minimi brevis (FDMBn) and the ulnar motor branch to the third lumbrical (3rdLn) were assessed for transfer. Coaptation success was measured by the overlap of the nerve donor with the RMN and correspondence of nerve diameters.ResultsThe mean transferable length and width of the RMN were 20.7 ± 4.5 and 1.0 ± 0.3 mm, respectively. We identified an average of three branches in the branching anatomy from the ulnar nerve to the hypothenar muscles. The maximal transferable lengths and widths of the FDMBn and the 3rdLn were 13.8 ± 4.4 and 0.5 ± 0.1 mm and 24.1 ± 6.4 and 0.4 ± 0.1 mm, respectively. The overlap with the RMN of the FDMBn and 3rdLn was 9.0 ± 3.6 (2.0–15.3) and 17.8 ± 6.0 (4.7–27.5) mm, respectively.ConclusionsThis anatomical study demonstrates the feasibility of distal nerve transfers between the ulnar and median nerves in the hand for reanimation of thenar muscles. Ulnar motor donors of the BrFDMBn and 3rdLn likely represent the least morbid donors with short distances for regeneration and a single coaptation repair.
Comparability of size measurements of the pancreas in magnetic resonance imaging and transabdominal ultrasound
Authors: Aghdassi Ali A. , Schauer Birgit , Duscha David , Ittermann Till , Pickartz Tilman , Budde Christoph , Simon Peter , Moskwa Patryk , Kromrey Marie L. , Bülow Robin , Völzke Henry , Kühn Jens , Lerch Markus M. 
Published: December 2019

AbstractIntroductionTransabdominal ultrasound (US) and magnetic resonance imaging (MRI) are commonly used for the examination of the pancreas in clinical routine. We therefore were interested in the concordance of these two imaging methods for the size measurement of the pancreas and how age, gender, and body mass index (BMI) affect the organ size.MethodsA total of 342 participants from the Study of Health in Pomerania underwent whole‐body MRI and transabdominal US on the same day, and the diameter of the pancreatic head, body, and tail were measured. The agreement between US and MRI measurements was assessed by Bland and Altman plots. Intraclass correlation coefficients were used to compare observers. A multivariable regression model was applied using the independent variables age, gender, and body mass index.ResultsCompared to MRI, abdominal US returned smaller values for each segment of the pancreas, with a high level of inconsistency between these two methods. The mean difference was 0.39, 0.18, and 0.54 cm for the head, body, and tail, respectively. A high interobserver variability was detected for US. Multivariable analysis showed that pancreatic size in all three segments increased with BMI in both genders whereas pancreatic head and tail size decreased with age, an effect more marked in women.ConclusionsAgreement of pancreatic size measurements is poor between US and MRI. These limitations should be considered when evaluating morphologic features for pathologic conditions or setting limits of normal size. Adjustments for BMI, gender, and age may also be warranted.
The sigmoidea ima artery: A player in colonic ischemia?
Authors: Landen Christoph , Dreu Manuel , Weiglein Andreas 
Published: December 2019

AbstractIntroductionThe sigmoidea ima artery is defined as the lowest sigmoid artery, which forms the distal end of the marginal artery by linking with the superior rectal artery. It supplies the rectosigmoid junction, which is a critical area for ischemia. The aim of the present study was to delineate the area supplied by the inferior mesenteric artery with special consideration of the sigmoidea ima artery.Materials and MethodsThe inferior mesenteric artery was dissected from its origin to the bifurcation of the superior rectal artery in 30 cadavers (15 male, 15 female). Vessel length and distance to the promontory were measured for each branch.ResultsThere were two manifestations of the sigmoidea ima artery, irrespective of the branching pattern of the inferior mesenteric artery. It originated below the promontory in 25 cases (83.3%) and above it in three (10%). It did not derive from the superior rectal artery in two cases (6.7%). In these 16.7%, the marginal artery was absent near the rectosigmoid junction.ConclusionsWe suggest the terms “arteria sigmoidea ima pelvina” and “arteria sigmoidea ima abdominalis” for the two variants. The terms “arteria marginalis pelvina” and “arteria marginalis abdominalis” could be applied in clinical practice. An abdominal marginal artery could be considered a risk factor for colonic ischemia in colorectal resections and abdominal aortic aneurysm repair. Both variants should be considered when pre‐ and intra‐operative perfusion measurements are interpreted.
Patterns of distant metastases in 215 Merkel cell carcinoma patients: Implications for prognosis and surveillance
Authors: Lewis Christopher W. , Qazi Jamiluddin , Hippe Daniel S. , Lachance Kristina , Thomas Hannah , Cook Maclean M. , Juhlin Ilsa , Singh Neha , Thuesmunn Zoe , Takagishi Seesha R. , McEvoy Aubriana , Doolittle‐Amieva Coley , Bhatia Shailender , Paulson Kelly G. , O'Malley Ryan B. , Wang Carolyn L. , Nghiem Paul 
Published: December 2019

AbstractApproximately one‐third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location of the primary lesion is predictive of initial distant metastatic site, or if survival likelihood differs depending on the metastatic site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate and competing‐risk analyses were performed on a cohort of 215 MCC patients with distant metastases, 31% of whom had two or more initial sites of distant metastasis. At time of initial distant metastasis in the 215 patients, metastatic sites (n = 305) included non‐regional lymph nodes (present in 41% of patients), skin/body wall (25%), liver (23%), bone (21%), pancreas (8%), lung (7%), and brain (5%). Among the 194 patients who presented with MCC limited to local or regional sites (stage I‐III) but who ultimately developed distant metastases, distant progression occurred in 49% by 1 year and in 80% by 2 years following initial diagnosis. Primary MCC locations differed in how likely they were to metastasize to specific organs/sites (P < .001). For example, liver metastases were far more likely from a head/neck primary (43% of 58 patients) versus a lower limb primary (5% of 39 patients; P < .0001). Skin‐only distant metastasis was associated with lower MCC‐specific mortality as compared to metastases in multiple organs/sites (HR 2.7; P = .003), in the liver (HR 2.1; P = .05), or in distant lymph nodes (HR 2.0; P = .045). These data reflect outcomes before PD1‐pathway inhibitor availability, which may positively impact survival. In conclusion, primary MCC location is associated with a pattern of distant spread, which may assist in optimizing surveillance. Because it is linked to survival, the site of initial distant metastasis should be considered when assessing prognosis.
Ischemic stroke as the first presentation of takayasu’s arteritis in young male
Authors: Gouda Wesam , Alsaqabi Faisal , Alkadi Amjad , Amr Hanan Abd El‐Aziz , Moshrif Abdelhafeez , Mahdy Mohammed E. 
Published: December 2019

AbstractTakayasu's arteritis should be kept under the differential diagnosis of stroke in all young patients. Early, proper diagnosis and treatment are necessary to reduce any further progression, morbidity, and mortality rates of the disease.
Origin of the High CO Oxidation Activity on CeO2 Supported Pt Nanoparticles: Weaker Binding of CO or Facile Oxygen Transfer from the Support?
Authors: Lu Yubing , Thompson Coogan , Kunwar Deepak , Datye Abhaya K. , Karim Ayman M. 
Published: December 2019

AbstractPt clusters supported on CeO2 are highly active for low temperature CO oxidation. The enhanced reactivity could be caused by weakening of the CO binding on Pt, allowing adsorbed oxygen to more effectively compete for sites. An alternative explanation is that interfacial sites allow adsorbed CO on Pt to react with lattice oxygen in the ceria. Here we explore the origins of enhanced CO oxidation reactivity on Pt/CeO2 using in‐situ/operando infrared and x‐ray spectroscopies, microcalorimetry, and reaction kinetics. We show that CO adsorbs strongly (∼110–120 kJ/mol) on Pt clusters (∼1.5 nm) and Pt is almost fully covered by CO during reaction, indicating that the high activity can be related to reactive interfacial O* species. Using in‐situ infrared spectroscopy we show that when the reaction mixture of CO and O2 stops flowing over the catalyst, the adsorbed CO on Pt is lost since it reacts with interfacial O*, but if this O* is depleted, the CO band does not disappear. The role of CeO2 is not to alter the binding of CO, but rather to enhance the reactivity of the interfacial metal‐support lattice oxygens. The reaction mechanism involving the interfacial Pt−CeO2 sites (two‐site mechanism) is further confirmed by kinetic measurements which show near zero order dependence on CO and O2 partial pressures.
Green Synthesis of Pyridyl Conjugated Microporous Polymers as Precursors for Porous Carbon Microspheres for Efficient Electrochemical Energy Storage
Authors: He Yan , Cheng Zhonghua , Zuo Hongyu , Yan Chunna , Liao Yaozu 
Published: December 2019

AbstractEfficient materials for electrochemical energy storage have received much attention. Herein we report a green metal‐free route to synthesize pyridyl conjugated microporous polymers (PCMPs) as precursors for nitrogen‐doped porous carbon microspheres (NCMs) with high surface areas up to 1232 m2 g−1 via a simple carbonization method. The resulting NCMs as supercapacitor electrodes exhibit high specific capacitance of 324 F g−1 at a current density of 0.1 A g−1, and high rate ability (182 F g−1 at 10 A g−1), and excellent cyclability (remained >97 % of initial capacitance at 2 A g−1 after 10000 cycles). This work also presents that molecular engineering of PCMP precursor, pyrolysis temperature and charge/discharge cycling allow the electrochemical energy storage properties of the NCMs to be controlled.
Efficient and Divergent Synthesis of Medium‐Sized Lactams through Zinc‐Catalyzed Oxidative Cyclization of Indoly Ynamides†
Authors: Li Hang‐Hao , Ye Si‐Han , Chen Yang‐Bo , Luo Wen‐Feng , Qian Peng‐Cheng , Ye Long‐Wu 
Published: December 2019

Summary of main observation and conclusionAn efficient zinc‐catalyzed oxidative cyclization of readily available indoly ynamides has been developed, enabling rapid and practical access to a diverse array of valuable medium‐sized lactams in mostly good to excellent yields with wide substrate scope. In addition, such an asymmetric synthesis has also been explored by employing the chiral substrate.
Effects of exergaming in postmenopausal women with high cardiovascular risk: A randomized controlled trial
Authors: Jo Eun‐Ah , Wu Shan‐Shan , Han Hyung‐Rae , Park Jung‐Jun , Park Saejong , Cho Kyoung‐Im 
Published: December 2019

AbstractObjectiveRecently, exergames have been used an exercise modality as aerobic fitness activities. However, evidence of its effectiveness on cardiovascular (CV)‐related risk factors remain unclear.HypothesisWe evaluate the effects of exergaming on CV‐related risk factors compared with traditional aerobic exercise in high CV risk patients.MethodsSixty‐five postmenopausal women with high CV risk were randomized among exergame (n = 22), treadmill (n = 22), and control (n = 21) groups. The exergame group was engaged in the running‐based exergame using Exer Heart and the treadmill group walked or jogged on a treadmill. Cardiorespiratory fitness, flow‐mediated dilation, endothelial progenitor cells (EPCs), epicardial fat thickness, metabolic parameters, and anthropometric parameters were measured in patients before and 12 weeks after the training.ResultsExergaming significantly improved VO2 peak (P < .001; different from control, P < .05), flow‐mediated dilation (P < .001; different from control, P < .05), EPCs (CD34/CD117+, P < .01). Treadmill exercise was effective at improving VO2 peak (P < .01; different from control, P < .05), flow‐mediated dilation (P < .05), EPCs (CD34/CD117+, P < .01; different from control P < .05). Epicardial fat thickness decreased after both exercise programs (exergame, P < .01; treadmill, P < .01; no different from control).ConclusionExergaming showed similar effects to traditional aerobic exercise in improving cardiorespiratory fitness and endothelial function in postmenopausal women with high CV risk. These findings suggest that the exergames may serve as an alternative to conventional aerobic exercises for prevention and treatment in high CV risk patients.
Differences in surgical resection rate and risk of malignancy in thyroid cytopathology practice between Western and Asian countries: A systematic review and meta‐analysis
Authors: Vuong Huy Gia , Ngo Hanh Thi Tuyet , Bychkov Andrey , Jung Chan Kwon , Vu Trang Huyen , Lu Kim Bach , Kakudo Kennichi , Kondo Tetsuo 
Published: December 2019

There is increasing evidence showing that clinicians employ different management strategies in their use of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). In this meta‐analysis, we investigated the differences in diagnosis frequency, resection rate (RR), and risk of malignancy (ROM) between Western (ie, American and European) and Asian cytopathology practices. We searched PubMed and Web of Science from January 2010 to January 2019. Proportion and 95% CIs were calculated using a random‐effect model. We used independent sample t tests to compare frequencies, RR, and ROM between Western and Asian practices. We analyzed a total of 38 studies with 145,066 fine‐needle aspirations. Compared with Asian practice, Western series had a significantly lower ROM in most of TBSRTC categories, whereas the RR was not statistically different. Focusing on indeterminate nodules, the RR in Western series was significantly higher (51.3% vs 37.6%; P = .048), whereas the ROM was significantly lower (25.4% vs 41.9%; P = .002) compared with those in Asian series. The addition of Asian cohorts increased ROM for most of diagnostic categories compared with the original TBSRTC. In conclusion, this study demonstrates a difference in Western and Asian thyroid cytology practice, especially regarding the indeterminate categories. Lower RR and higher ROM suggest that Asian clinicians adopt a more conservative approach, whereas immediate diagnostic surgery is favored in Western practice for indeterminate nodules. The addition of Asian series into a meta‐analysis of TBSRTC altered ROM for several categories, which should be considered in future revisions of TBSRTC.
A multiscale subvoxel perfusion model to estimate diffusive capillary wall conductivity in multiple sclerosis lesions from perfusion MRI data
Authors: Koch Timo , Flemisch Bernd , Helmig Rainer , Wiest Roland , Obrist Dominik 
Published: December 2019

AbstractWe propose a new mathematical model to learn capillary leakage coefficients from dynamic susceptibility contrast MRI data. To this end, we derive an embedded mixed‐dimension flow and transport model for brain tissue perfusion on a subvoxel scale. This model is used to obtain the contrast agent concentration distribution in a single MRI voxel during a perfusion MRI sequence. We further present a magnetic resonance signal model for the considered sequence including a model for local susceptibility effects. This allows modeling MR signal‐time curves that can be compared with clinical MRI data. The proposed model can be used as a forward model in the inverse modeling problem of inferring model parameters such as the diffusive capillary wall conductivity. Acute multiple sclerosis lesions are associated with a breach in the integrity of the blood‐brain barrier. Applying the model to perfusion MR data of a patient with acute multiple sclerosis lesions, we conclude that diffusive capillary wall conductivity is a good indicator for characterizing activity of lesions, even if other patient‐specific model parameters are not well‐known.
Finite element generation of sibilants /s/ and /z/ using random distributions of Kirchhoff vortices
Authors: Pont Arnau , Guasch Oriol , Arnela Marc 
Published: December 2019

AbstractThe numerical simulation of sibilant sounds in three‐dimensional realistic vocal tracts constitutes a challenging problem because it involves a wide range of turbulent flow scales. Rotating eddies generate acoustic waves whose wavelengths are inversely proportional to the flow local Mach number. If that is low, very fine meshes are required to capture the flow dynamics. In standard hybrid computational aeroacoustics (CAA), where the incompressible Navier‐Stokes equations are first solved to get a source term that is secondly input into an acoustic wave equation, this implies resorting to supercomputer facilities. As a consequence, only very short time intervals of the sibilant can be produced, which may be enough for its spectral characterization but insufficient to synthesize, for instance, an audio file from it or a syllable sound. In this work, we propose to substitute the aeroacoustic source term obtained from the computational fluid dynamics (CFD) in the first step of hybrid CAA, by a random distribution of Kirchhoff's spinning vortices, located in the region between the upper incisors and the lower lip. In this way, one only needs to solve a linear wave equation to generate a sibilant, and therefore avoids the costly large‐scale computations. We show that our proposal can recover the outcomes of hybrid CAA simulations in average, and that it can be applied to generate sibilants /s/ and /z/. Modeling and implementation details of the Kirchhoff vortex distribution in a stabilized finite element code are discussed in the paper, as well as the outcomes of the simulations.