bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy, Safety and Adherence to Treatment when New Anticoagulants Taking in Over 75 Years Old Patients with Atrial Fibrillation
Authors: Turov A. N. , Panfilov S. V. , Tschiglinzeva О. V. 
Published: March 2020

Aim. To study the efficacy, safety, and adherence to therapy with new oral anticoagulants in patients older than 75 years with atrial fibrillation.Material and methods. Patients (n=431) over 75 years old (82.7±3.4 years) with various types of atrial fibrillation/flutter (AF) were included in a nonrandomized observational study of new oral anticoagulants (NOAC) in real clinical practice. A history of cardiac surgery was in 27.6% of patients. All patients had >3 risk factors for ischemic stroke (CHA2DS2-VASс 4.81±0.4 points) and >1 risk factor for bleeding (HAS-BLED 3.01±0.2 points). The duration of the observation study was from 12 to 42 (26.9±4.9) months. Dabigatran was taken in 38.5% (n=166) of patients, rivaroxaban – in 41.3% (n=178), apixaban – in 20.2% (n=87) of patients.Results. The incidence of new cases of myocardial infarction was 0.8% per year, surgical revascularization – 0.9% per year, cardiovascular death – 0.8% per year. The frequency of ischemic stroke was 1.1% per year, transient ischemic attacks – 0.4% per year, all thromboembolic episodes – 1.77% per year. The incidence of intracranial hemorrhage was 0.2% per year, of minor bleeding – 4.4% per year, of the combined cardiac point (the total frequency of all strokes, major bleeding, myocardial infarction, mortality from cardiovascular causes, revascularization procedures) – 4.2% per year. Significant differences in the frequency of endpoints depending on the drug of NOAC taken by patients were not found. Violations of the regimen and doses were more often observed with twice daily intake (63.9% for dabigatran and 59.8% for apixaban) than with a single dosage regimen per day (45.5% for rivaroxaban). The leading causes of non-adherence to NOAC therapy in patients over 75 years of age included skipping the next scheduled dose (43.6%) and changing the frequency of the drug taking (16.9%). For NOAC with a double dose per day, dabigatran and apixaban, the frequency of administration was violated in 27.7% and 28.7%, respectively, and with a single dose per day, rivaroxaban – in 1.1%.Conclusion. Therapy with NOAC in patients older than 75 years with AF is effective and safe. There were no statistically significant differences in the incidence of thromboembolic or hemorrhagic events during three NOACs treatment in patients with AF older than 75 years. The incidence of non-adherence was less
The mutational spectrum of Hunter syndrome reveals correlation between biochemical and clinical profiles in Tunisian patients
Authors: chkioua latifa , Grissa Oussama , Leban Nadia , Gribaa Moez , Boudabous Hela , Turkia Hadhami Ben , Ferchichi Salima , Tebib Neji , Laradi Sandrine 
Published: March 2020

Abstract

Background:Mucopolysaccharidosis type II (MPS II) or Hunter syndrome is an X-linked recessive lysosomal storage disorder resulting from deficient activity of iduronate 2-sulfatase (IDS) and the progressive lysosomal accumulation of sulfated glycosaminoglycans (GAGs).Methods:A diagnosis of MPS II or Hunter syndrome was performed based on the following approach after a clinical and paraclinical suspicion. Two biochemical and molecular tests were carried out separately and according to the availability of the biological material.Results:All patients in this cohort presented the most common MPS II clinical features. Electrophoresis of GAGs on a cellulose acetate plate in the presence of a high concentration of heparane sulfate showed an abnormal dermatan sulfate band in the patients compared with that in a control case. Furthermore, leukocyte IDS activity ranged from 0.00 to 0.75 nmol/h/mg of leukocyte protein in patients.Five previously reported mutations were identified in this study patients: one splice site mutation, c.240+1G>A; two missense mutations, p.R88P and p.G94D; a large deletion of exon 1 to exon 7; and one nonsense mutation, p.Q396*. In addition, two novel alterations were identified in the MPS II patients: one frame shift mutation, p.D450Nfs*95 and one nonsense mutation, p.Q204*. Additionally, five knownIDSpolymorphisms were identified in the patients: c.419-16 delT, c.641C>T (p.T214M), c.438 C>T (p.T146T), c.709-87G>A, and c.1006+38T>C.Conclusions:The high level of urine GAGs and the deficiency of iduronate 2-sulfatase activity was associated with the phenotype expression of Hunter syndrome. Molecular testing was useful for the patients’ phenotypic classification and the detection of carriers.
Tumor Necrosis Factor-α, Caspase-9 and Heat Shock Protein 70 Expressions with Leukemia Inhibitory Factor in Hydrosalpinx
Authors: Syam Hanom Husni , Djuwantono Tono , Effendi Jusuf S. , Idjradinata Ponpon S. , Madjid Tita H. , Permadi Wiryawan , Septiani Leri 
Published: March 2020

Abstract
Background The leakage of hydrosalpinx fluid from the tube into the uterine cavity is likely to interfere with normal implantation. Hydrosalpinx fluids contain tumor necrosis factor-α (TNF-α), which induces caspase-9 signal transduction, leading to apoptosis. Endometrial cells inhibit apoptosis by synthesizing heat shock protein 70 (Hsp70). The TNF-α, caspase-9 and Hsp70 factors are closely related to apoptosis. In women with hydrosalpinx, the endometrial receptivity of embryonic implantation processes is low. Endometrial receptivity can be assessed by leukemia inhibitory factor (LIF). TNF-α, caspase-9 and Hsp70 expression plays an important role in endometrial receptivity disorders in women with hydrosalpinx.Materials and Methods These is an analytic observational, cross-sectional and categorical comparative study was conducted in 44 subjects with and without hydrosalpinx. The present study was performed in Dr. Hasan Sadikin Hospital, Grha Bunda-, Limijati-Maternity and Children Hospital (May-June 2017). Immunohistochemistry was performed with a cutoff based on the ROC. The Mann-Whitney analysis was performed on TNF-α, caspase-9, Hsp70 and LIF in both groups, whereas a correlation regression test was performed to observe the correlation among these protein.Results The present study used the histoscore as a tool to evaluate the expression of variable between study groups. The comparison of the histoscore for parameters between hydrosalpinx and non-hydrosalpinx subjects was TNF-α (12 vs 9; p<0,001), caspase-9 (12 vs 8,5; p<0,001), Hsp70 (6 vs 8; p<0,001), and LIF (9 vs 12; p<0,05), respectively.Conclusion The results showed a significant difference in TNF-α, caspase-9, Hsp70 and LIF (p <0.05) between hydrosalpinx and non-hydrosalpinx patients. Caspase-9 and Hsp70 are inter-connected and related to LIF as a marker in the endometrium receptivity by hydrosalpinx patients.
Th1/Th17 cytokine profiles are associated with disease severity and exacerbation frequency in COPD patients
Authors: Yu Yan , Zhao Lili , Xie Yu , Xu Yu , Jiao Weike , Wu Jianhui , Deng Xinyu , Fang Guiju , Xue Qing , Zheng Yali , Gao Zhancheng 
Published: March 2020

Abstract
Background T helper (Th) cell cytokine imbalances have been associated with the pathophysiology of chronic obstructive pulmonary disease (COPD), including the Th1/Th2 and Th17/Treg paradigms. Clarifying cytokine profiles during COPD acute exacerbation (AE) and their relationships with clinical manifestations would help in understanding the pathogenesis of disease and improve clinical management.Methods Patients admitted to the hospital with AEs of COPD from January 2017 to August 2017 were included in this study, and follow-up was conducted after discharge (every 30 days, for a total of 120 days). Sputum samples of patients at different time points (including at admission, discharge, and follow-up) were collected, and sputum cytokine profiling (12 cytokines in total) was performed using a Luminex assay. Clinical data of patients were collected by a unified electronic medical record form.Results A total of 87 patients with COPD were enrolled, aged 72 ± 8.5 years, among whom 1, 12, 32, and 42 cases exhibited GOLD stage I, II, III, and IV, respectively. According to the cytokine profiles at admission, patients were divided into three clusters by a k -means clustering algorithm, namely, Th1 high Th17 high (n=26), Th1 low Th17 low (n=56), and Th1 high Th17 low (n=5), which revealed distinct clinical characteristics. Patients with Th1 high Th17 low profile had a significantly longer length of non-invasive ventilation time and length of hospital stay than patients with Th1 high Th17 high profile (7 vs. 0 days, 22 vs. 11 days, respectively, p < 0.05), and had the highest AE frequency. Sputum levels of Th17 cytokines (IL-17A, IL-22, and IL-23) during AE were negatively correlated with AE frequency in the last 12 months ( r = -0.258, -0.289 and -0.216, respectively, p < 0.05). Moreover, decreased sputum IL-17A levels were independently associated with increased AE frequency, whith an OR (95% CI) of 0.975 (0.958 - 0.993) and a p = 0.006.Conclusion Th1/Th17 imbalance during AE is associated with the severity of COPD. Decreased Th17 cytokine expression is correlated with increased AE frequency. The Th1/Th17 balance may be a specific target for the therapeutic manipulation of COPD.Trial registration: ClinicalTrials.gov ID: NCT03236480.
Assessment the Quality of Services in Health Tourism using structural equation modeling (SEM) and confirmatory factor analysis (CFA): a case study in Mashhad, Iran
Authors: Hemmati Farhad , Mahmoudi Ghahraman , Dabbaghi Fatemeh 
Published: March 2020

Abstract
Background: It is essential to improve the quality of services to satisfy health tourists. Thus, the present study was conducted to determine the relationship between quality of health services and tourism in Mashhad.Methods: In this descriptive study, there were 120 subjects from the first population and 384 from the second. They completed a standard questionnaire with items related to demographic characteristics and tourism facilities in the five districts (north, south, east, west, and center) of Mashhad from 2017 to 2018. Data was analyzed using confirmatory factor analysis (CFA) and structural equation modeling (SEM). Spss21 and LISREL8.50 were used as the software. Results: t-test results showed that the factor loadings were more than 1.96, so there was a correlation between the quality of services provided and health tourism in Mashhad. Conclusion: According to the results, the importance of health tourism is so high that efforts for its development it in the region will lead to an all-comprehensive development. Hence, it is suggested that by strengthening the quality of services health tourism be improved in Mashhad.
Pre-clinical studies of honey-related synthetic peptides in malignancy control
Authors: Elawdan Khaled M.E , Elawdan Youssof K. , Eldrieny Ezzat A. , Samy Mohammed B. 
Published: March 2020

Abstract
Backgound: The challenge with malignancy control approaches, although of all traditional methods of treatment like surgery, chemotherapy, radiotherapy, immunotherapy etc. makes more stress upon the scientific community to look for a solution for this challenge even far from the traditional ways. Methods: A growth inhibitory assay was performed. Samples of peptide A and peptide F, 5 mg each, were dissolved in 500 μL Dulbecco’s Phosphate-Buffered Saline to prepare the stock solution, which was added into the wells directly. A 1% trifluoroacetic acid (TFA) solution was used as the control. (a) Cells were placed into a 96-well assay plate at a density of 5000 and 10000 cells/well for adherent and suspension cell lines, respectively, with a 50 μL complete cell culture medium. (b) Stock solutions (10 μL) of the compounds were added into the wells. (c) For data analysis, 10 μL 1% TFA solution was used as control. (d) Complete medium of 40 μL was added into the wells to reach a total volume of 100 μL. (e) The plate was incubated at 37℃ for 72 hours. (f) CellTiter-Glo assay mix solution (50 μL) was added to each well and mixed gently at room temperature for 10 minutes; subsequently, the luminescence was read using PHERAstar Plus (Molecular Devices). Results: Apparent inhibitory effects of those peptides were noticed in 17 of 18 tumour cell lines. Similar effects were noted in an in vivo study using the U87MG tumour mouse model. Conclusion: This study has introduced new synthetic peptides derived from honey proteins, which may help in cancer control through direct apoptotic action not limited to only a certain tumour cell line. Patent: WO/2014/040605A1, US/2015/0291663A1, and CN105283198A.
Evolution of CT Findings in Patients with COVID-19 Pneumonia
Authors: Liang Ting , C.Wu Carol , liu Zhe , Jin Chao , Zhao Huifang , Wang Yan , Wang Zekun , Li Fen , Zhou Jie , Cai Shubo , Liang Yukun , Zhou Heping , Wang Xibin , Ren Zhuanqin , Yang Jian 
Published: March 2020

Abstract
Objectives To delineate the evolution of CT findings in patients with mild COVID-19 pneumonia outside of Wuhan.Methods CT images and medical records of 88 patients with confirmed mild COVID-19 pneumonia outside of Wuhan, a baseline and at least one follow-up CT were retrospectively reviewed. CT features including lobar distribution and presence of ground glass opacities (GGO), consolidation, and linear opacities, were analyzed on per patient basis during each of five time intervals spanning the three weeks after disease onset. Total severity scores were calculated.Results 85.2 % of patients had travel history to Wuhan or known contact with infected individuals. The most common symptoms were fever (84.1%) and cough (56.8%). The baseline CT was obtained on average 5 days from symptom onset. Four patients (4.5%) had negative initial CT. Significant differences were found among the time intervals in the proportion of pulmonary lesions that are 1) pure GGO, 2) mixed attenuation, 3) mixed attenuation with linear opacities, 4) consolidation with linear opacities, and 5) pure consolidation. The majority of patients had involvement of ≥ 3 lobes. Bilateral involvement was more prevalent than unilateral involvement. The proportions of patients observed to have pure GGO or GGO and consolidation decreased over time while proportion of patients with GGO and linear opacities increased. Total severity score showed an increasing trend in the first two weeks. Conclusions While bilateral GGO are predominant features, CT findings changed during different time intervals in the three weeks after symptom onset in patients with COVID-19.
Parameter optimization and mechanism research of enhanced coagulation treatment for Yuquan River water
Authors: Sun Qianshu , Zhao Shuang , Yan Yubo , Jia Wenlin , Yang Weihua 
Published: March 2020

Abstract
As one of the drinking water sources for Xuzhou city, Yuquan River has been polluted seriously in recent years. In this paper, enhanced coagulation technology was selected and various parameters (coagulant species, dosage, solution pH and coagulant aid species) were optimized for Yuquan River water treatment. Turbidity and UV254 removal rate were calculated to assess coagulation efficiencies, and meanwhile floc generation kinetics, zeta potential and scanning electron microscope (SEM) spectra were measured to study the coagulation mechanism. Results indicated that the coagulation effect of polyaluminium chloride (PAC) on Yuquan River water was better than that of aluminium sulphate (AS), and its optimal dosage was 20 mg/L. Flocs produced by PAC also exhibited larger size and faster growth velocity than those of AS. Moreover, the applicable initial pH range for Yuquan River was 6.0–9.0, and the optimal coagulation efficiency was observed at pH 7.0. When PAC or AS was selected as coagulant, the application of sodium alginate (SA) could improve turbidity and UV254 removal due to its adsorption bridging role. In addition, coagulation efficiency could be enhanced in an AS coagulation system when polyacrylamide (PAM) was dosed as coagulant aid.
Application of Moringa oleifera Lam. fractionated proteins for inactivation of Escherichia coli from water
Authors: Silveira Fabiane Masala R. , Baptista Aline Takaoka A. , Dutra Tatiane V. , de Abreu Filho Benício Alves , Gomes Raquel G. , Bergamasco Rosângela 
Published: March 2020

Abstract
Chemical products traditionally used in the disinfection of water bodies often pose human health risks. For this reason, studies on natural coagulants such as Moringa oleifera Lam. represent an alternative for the inactivation of pathogenic microorganisms, among which is Escherichia coli. This study evaluated the effect of different concentrations of coagulants obtained from Moringa seed extracts and their protein fractions in the inactivation of E. coli during the coagulation/flocculation process. The coagulants studied were the aqueous extract, saline extract and protein fractions albumin and globulin, highlighting that the protein fractions were more effective on inactivating E. coli. The protein fraction globulin at a concentration of 10.0 mg L−1 showed bactericidal effects against E. coli within 18 min, whereas the albumin showed a bacteriostatic effect within 48 min because it isolated colonies in the sediment sample.
Study on demulsification and deoiling for O/W emulsion by microbubble pretreated resin
Authors: Wang Xiaoping , Liu Wei , Liu Xueqian , Luo Jihang 
Published: March 2020

AbstractThe microbubble pretreated resin was used for demulsification and deoiling of the simulated O/W emulsion. The demulsification and deoiling performance and the influencing factors were investigated systematically. Experimental results indicate that the microbubble pretreated resin reaches a 97% oil removal within 80 min; on the contrary, oil removals are 90% and 85% for NaOH solution soaked and un-pretreated resins respectively. After five repeated runs, the oil removal of microbubble pretreated resin can be maintained at over 70%. The demulsification mechanism was revealed by comparing zeta potential, surface tension, contact angle of the emulsion in treatment, and the characterization results of the resin before and after use. Three possible pathways of demulsification were concluded and the ranking contributions can be shown below. Pathway 1: Competitive trapping of surfactant. The cationic groups of the resin combine with the anionic groups of the surfactant and drag them away from the oil particle surface. Pathway 2: Distribution equilibrium of surfactant. Free surfactants in the emulsion are captured by resin and reduce the concentration of uncombined surfactant. This results in surfactants on the oil particle partly detaching from the oil surface to maintain the adsorption-desorption equilibrium of the surfactant. Pathway 3: Adsorption coalescence.
Preparation of sludge-based hydrochar at different temperatures and adsorption of BPA
Authors: Chen Liyuan , Li Dapeng , Huang Yong , Zhu Wenjuan , Ding Yuqin , Guo Chaoran 
Published: March 2020

Abstract
This study sought a new way to utilize sludge as a low cost and efficient adsorbent. Preparation of sludge adsorbent by hydrothermal carbonization was done at different temperatures (160–250 °C). Various characterization techniques were used in this study including elemental analysis, Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). The adsorption performance of the organic matter was analyzed by adsorption experiments with the endocrine disruptor bisphenol A (BPA). Results showed that as the hydrothermal temperature increased, the solid yield of hydrochar decreased from 84.73% to 55.19%, and the maximum specific surface area was 11.9 m2/g. Elemental analysis showed that the hydrochar contains more aromatic carbon than the raw sludge. It was found using the FT-IR and XPS that the hydrochar retains a large amount of oxygen-containing functional groups on the surface after hydrothermal treatment. Hydrochar can be used as an organic-pollutant adsorbent in water; it has a good adsorption effect on BPA and the removal rate can reach 96%. The adsorbed hydrochar can be hydrothermally retreated and returned to the sewage treatment plant for reuse.
MRI Radiomics Classification and Prediction in Alzheimer’s Disease and Mild Cognitive Impairment: A Review
Authors: Feng Qi , Ding Zhongxiang 
Published: March 2020

Background:
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that
threatens the health of the elderly. Mild Cognitive Impairment (MCI) is considered to be the prodromal
stage of AD. To date, AD or MCI diagnosis is established after irreversible brain structure alterations.
Therefore, the development of new biomarkers is crucial to the early detection and treatment of this
disease. At present, there exist some research studies showing that radiomics analysis can be a good
diagnosis and classification method in AD and MCI.

Objective:
An extensive review of the literature was carried out to explore the application of radiomics
analysis in the diagnosis and classification among AD patients, MCI patients, and Normal Controls
(NCs).

Results:
Thirty completed MRI radiomics studies were finally selected for inclusion. The process of
radiomics analysis usually includes the acquisition of image data, Region of Interest (ROI) segmentation,
feature extracting, feature selection, and classification or prediction. From those radiomics methods,
texture analysis occupied a large part. In addition, the extracted features include histogram, shapebased
features, texture-based features, wavelet features, Gray Level Co-Occurrence Matrix (GLCM),
and Run-Length Matrix (RLM).

Conclusion:
Although radiomics analysis is already applied to AD and MCI diagnosis and classification,
there still is a long way to go from these computer-aided diagnostic methods to the clinical application.
Maternal Outcomes of Hysterectomy and Conservative Surgery in Placenta Accreta
Authors: Lubis Muara Panusunan , Yaznil Muhammad Rizki , Barus Melvin N.G. , Asroel Edwin Martin , Faustine Michelle 
Published: March 2020

Background:
Abnormal invasive placentation or placenta accreta spectrum (PAS) has
been an emerging disease in developing countries where cesarean sections are routinely performed.
Here we report our own data to contribute to the variety of techniques for reducing morbidity and
mortality in placenta accreta cases across the world.

Objective:
This study aims to analyze maternal outcomes, associated risk factors, and our surgery
technique in placenta accreta patients treated at Haji Adam Malik Hospital, Indonesia.

Methods:
We conducted a retrospective study in a tertiary hospital in North Sumatra, with a total of
70 patients suspected to have placenta accreta between January 2017 and June 2019. We compared
age, gestational age, previous cesarean section, history of antepartum bleeding, placenta accreta
index score, and intraoperative data, including the type of anesthesia, estimated blood loss, the need
for transfusion, duration of surgery, complication, and management of the patient.

Results:
From 70 suspected cases of placenta accreta, 52 (74.2%) patients were diagnosed with
placenta accreta and 18 (25.7%) were diagnosed with placenta previa (non-accreta) during surgery.
Of the 52 placenta accreta patients, hysterectomy was performed in 42 and the other 10 were treated
with conservative surgical procedures. Morbidities such as bladder injury (5.8%; 3/42) and iliac
vein injury (4.8%; 2/42) were reported during hysterectomy. There were two (4.8%) mortalities
reported.

Conclusion:
PAS is an emerging disease with high mortality and morbidity rates, which requires
comprehensive management including referral to a multidisciplinary care team for diagnosis and
management.