bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil carbon fluxes and balances of crop rotations under long-term no-till
Authors: Rigon João Paulo Gonsiorkiewicz , Calonego Juliano Carlos 
Published: September 2020

Abstract
Background
A field study with the same crop rotations was conducted to test the hypothesis that the soil Carbon fluxes and balances could vary according to the crop species and also mitigate carbon dioxide (CO2) emission. This study aimed to assess the CO2 emission from crop rotations according to C and N inputs from crop residue, the influences on soil organic carbon (SOC) and total soil nitrogen (TN) stocks, identifying the soybean production systems with positive C balance. Triticale (x Triticosecale) or sunflower (Helianthus annuus) are grown in the fall/winter; sunn hemp (Crotalaria juncea), forage sorghum (Sorghum bicolor), pearl millet (Pennisetum glaucum), or fallow are the spring treatments, and soybean as a main crop in summer.

Results
We found that high C inputs from crop residues modify the C dynamics in crop rotations by reducing the C output (CO2) and increasing C sequestration in the soil. In general, the higher SOC, C stocks, and TN in soil surface were due to higher C and N inputs from sunn hemp or forage sorghum crop residues in spring. These crops also produced lower accumulated CO2 emissions and, when rotating with triticale in the fall-winter season resulted in a positive C balance, making these soybean crop rotations more efficient.

Conclusion
Our study suggests the ideal crop species choice in a rotation can mitigate the CO2 emissions by increasing C and N input from crop residues and consequently SOC and C stocks. In particular, crop rotation comprises an important tool to achieve a positive C balance, mitigate CO2 emissions and provide an additional ecosystem service to soybean cultivation option.
NAUTICA: classifying transcription factor interactions by positional and protein-protein interaction information
Authors: Perna Stefano , Pinoli Pietro , Ceri Stefano , Wong Limsoon 
Published: September 2020

Abstract
Background
Inferring the mechanisms that drive transcriptional regulation is of great interest to biologists. Generally, methods that predict physical interactions between transcription factors (TFs) based on positional information of their binding sites (e.g. chromatin immunoprecipitation followed by sequencing (ChIP-Seq) experiments) cannot distinguish between different kinds of interaction at the same binding spots, such as co-operation and competition.

Results
In this work, we present the Network-Augmented Transcriptional Interaction and Coregulation Analyser (NAUTICA), which employs information from protein-protein interaction (PPI) networks to assign TF-TF interaction candidates to one of three classes: competition, co-operation and non-interactions. NAUTICA filters available PPI network edges and fits a prediction model based on the number of shared partners in the PPI network between two candidate interactors.

Conclusions
NAUTICA improves on existing positional information-based TF-TF interaction prediction results, demonstrating how PPI information can improve the quality of TF interaction prediction. NAUTICA predictions - both co-operations and competitions - are supported by literature investigation, providing evidence on its capability of providing novel interactions of both kinds.

Reviewers
This article was reviewed by Zoltán Hegedüs and Endre Barta.
Predictive significance of arachidonate 15-lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps
Authors: Liang Zhuoping , Yan Bing , Liu Chang , Tan Ruyu , Wang Chengshuo , Zhang Luo 
Published: September 2020

Abstract
Background
Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) exhibits a poorer outcome compared with non-eosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP), so it is significant to identify effective markers to differentiate ECRSwNP in guiding the treatment strategies of these patients. Although arachidonate 15-lipoxygenase (ALOX15) is positioned as a marker of eosinophilic inflammation, its study in differentiating ECRSwNP has not been reported. The aim of this study is to assess the potential of ALOX15 in distinguishing and predicting ECRSwNP.

Methods
Forty-eight patients with chronic rhinosinusitis with nasal polyps (CRSwNP), including 30 ECRSwNP and 18 nonECRSwNP patients, were enrolled. ALOX15 mRNA level was determined in polyps by real-time polymerase chain reaction (RT-PCR). The patients’ baseline characteristics were evaluated and analyzed for correlations with ALOX15. Receiver operating characteristic (ROC) curve was used to assess the predictive significance of the potential predictors for ECRSwNP.

Results
ALOX15 mRNA level was significantly higher in ECRSwNP patients than in nonECRSwNP patients (P < 0.001). ALOX15 mRNA was significantly correlated with tissue and blood eosinophil percentages (r = 0.565, P < 0.001 and r = 0.395, P = 0.006), olfaction scores (r = 0.400, P = 0.005), total visual analogue scale (VAS) symptom scores (r = 0.383, P = 0.007), ethmoid/maxillary sinus (E/M) ratio (r = 0.463, P = 0.001), and endoscopy scores (r = 0.409, P = 0.004). Logistic regression analysis showed ALOX15 mRNA level and percentage of blood eosinophils to be predictive factors for ECRSwNP (P = 0.004 and P = 0.036, respectively). ROC curve indicated ALOX15 to have high predictive accuracy for ECRSwNP (area under the curve (AUC) = 0.909), which was further improved by combination of ALOX15 with percentage of blood eosinophils (AUC = 0.933).

Conclusions
The relative ALOX15 mRNA level alone or in combination with blood eosinophils might be a reliable biomarker for predicting a diagnosis of ECRSwNP.
Synchronization and resilience in the Kuramoto white matter network model with adaptive state-dependent delays
Authors: Park Seong Hyun , Lefebvre Jérémie 
Published: September 2020

AbstractWhite matter pathways form a complex network of myelinated axons that regulate signal transmission in the nervous system and play a key role in behaviour and cognition. Recent evidence reveals that white matter networks are adaptive and that myelin remodels itself in an activity-dependent way, during both developmental stages and later on through behaviour and learning. As a result, axonal conduction delays continuously adjust in order to regulate the timing of neural signals propagating between different brain areas. This delay plasticity mechanism has yet to be integrated in computational neural models, where conduction delays are oftentimes constant or simply ignored. As a first approach to adaptive white matter remodeling, we modified the canonical Kuramoto model by enabling all connections with adaptive, phase-dependent delays. We analyzed the equilibria and stability of this system, and applied our results to two-oscillator and large-dimensional networks. Our joint mathematical and numerical analysis demonstrates that plastic delays act as a stabilizing mechanism promoting the network’s ability to maintain synchronous activity. Our work also shows that global synchronization is more resilient to perturbations and injury towards network architecture. Our results provide key insights about the analysis and potential significance of activity-dependent myelination in large-scale brain synchrony.
Immunoprecipitation and mass spectrometry define TET1 interactome during oligodendrocyte differentiation
Authors: Zhang Ming , Zhang Kaixiang , Wang Jian , Liu Yuming , Liu Guangxin , Jin Weilin , Wu Shengxi , Zhao Xianghui 
Published: September 2020

AbstractTen-eleven translocation (TET) proteins, encoding dioxygenase for DNA hydroxymethylation, are important players in nervous system development and disease. In addition to their proverbial enzymatic role, TET proteins also possess non-enzymatic activity and function in multiple protein–protein interaction networks, which remains largely unknown during oligodendrocyte differentiation. To identify partners of TET1 in the myelinating cells, we performed proteome-wide analysis using co-immunoprecipitation coupled to mass spectrometry (IP-MS) in purified oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes (mOLs), respectively. Following a stringent selection of MS data based on identification reliability and protein enrichment, we identified a core set of 1211 partners that specifically interact with TET1 within OPCs and OLs. Analysis of the biological process and pathways associated with TET1-interacting proteins indicates a significant enrichment of proteins involved in regulation of cellular protein localization, cofactor metabolic process and regulation of catabolic process, et al. We further validated TET1 interactions with selected partners. Overall, this comprehensive analysis of the endogenous TET1 interactome during oligodendrocyte differentiation suggest its novel mechanism in regulating oligodendrocyte homeostasis and provide comprehensive insight into the molecular pathways associated with TET1.
Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review
Authors: Sakr Yasser , Giovini Manuela , Leone Marc , Pizzilli Giacinto , Kortgen Andreas , Bauer Michael , Tonetti Tommaso , Duclos Gary , Zieleskiewicz Laurent , Buschbeck Samuel , Ranieri V. Marco , Antonucci Elio 
Published: September 2020

Abstract
Background
Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).

Main text
We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6–8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.

Conclusion
Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The use of an intermediate therapeutic dose of low molecular weight (LMWH) or unfractionated heparin can be considered on an individual basis in patients with multiple risk factors for venous thromboembolism, including critically ill patients admitted to the ICU. Decisions about extending prophylaxis with LMWH after hospital discharge should be made after balancing the reduced risk of venous thromboembolism (VTE) with the risk of increased bleeding events and should be continued for 7–14 days after hospital discharge or in the pre-hospital phase in case of pre-existing or persisting VTE risk factors. Therapeutic anticoagulation is the cornerstone in the management of patients with PE. Selection of an appropriate agent and correct dosing requires consideration of underlying comorbidities.
Some new Simpson-type inequalities for generalized p-convex function on fractal sets with applications
Authors: Abdeljawad Thabet , Rashid Saima , Hammouch Zakia , İşcan İmdat , Chu Yu-Ming 
Published: September 2020

AbstractThe present article addresses the concept ofp-convex functions on fractal sets. We are able to prove a novel auxiliary result. In the application aspect, the fidelity of the local fractional is used to establish the generalization of Simpson-type inequalities for the class of functions whose local fractional derivatives in absolute values at certain powers arep-convex. The method we present is an alternative in showing the classical variants associated with generalizedp-convex functions. Some parts of our results cover the classical convex functions and classical harmonically convex functions. Some novel applications in random variables, cumulative distribution functions and generalized bivariate means are obtained to ensure the correctness of the present results. The present approach is efficient, reliable, and it can be used as an alternative to establishing new solutions for different types of fractals in computer graphics.
Generating functions for some families of the generalized Al-Salam–Carlitz q-polynomials
Authors: Srivastava Hari Mohan , Arjika Sama 
Published: September 2020

AbstractIn this paper, by making use of the familiarq-difference operators$D_{q}$Dqand$D_{q^{-1}}$Dq−1, we first introduce two homogeneousq-difference operators$\mathbb{T}(\mathbf{a},\mathbf{b},cD_{q})$T(a,b,cDq)and$\mathbb{E}(\mathbf{a},\mathbf{b}, cD_{q^{-1}})$E(a,b,cDq−1), which turn out to be suitable for dealing with the families of the generalized Al-Salam–Carlitzq-polynomials$\phi_{n}^{(\mathbf{a},\mathbf{b})}(x,y|q)$ϕn(a,b)(x,y|q)and$\psi_{n}^{(\mathbf{a},\mathbf{b})}(x,y|q)$ψn(a,b)(x,y|q). We then apply each of these two homogeneousq-difference operators in order to derive generating functions, Rogers type formulas, the extended Rogers type formulas, and the Srivastava–Agarwal type linear as well as bilinear generating functions involving each of these families of the generalized Al-Salam–Carlitzq-polynomials. We also show how the various results presented here are related to those in many earlier works on the topics which we study in this paper.
Effect of unintended pregnancy on skilled antenatal care uptake in Bangladesh: analysis of national survey data
Authors: Khan Md Nuruzzaman , Harris Melissa L. , Oldmeadow Christopher , Loxton Deborah 
Published: September 2020

Abstract
Background
Around 48% of all pregnancies in low- and middle-income countries are unintended. Unintended pregnancy may contribute to lower use of antenatal care (ANC); however, current research in the area is largely inconclusive due to the methodological approaches applied.

Methods
Responses from 4493 women extracted from the 2014 Bangladesh Demographic and Health Survey (BDHS) were used to assess the association between unintended pregnancy and subsequent uptake of at least one and at least four skilled ANC visits. For this, Bayesian multilevel logistic regression models with informative priors (representing a range of values within which the researcher is certain the true effect of the parameters included lies) were used, adjusting for other factors that affect ANC uptake. Informative priors were selected from the BDHS data collected in 2004, 2007, and 2011.

Results
Around 64% of women in Bangladesh who had at least one pregnancy within 3 years prior to the survey (that ended in a live birth) received ANC at least once, and of these around 32% used ANC at least four times. Mistimed (aOR, 0.73, 95% Cred I, 0.66–0.81) and unwanted (aOR, 0.69, 95% Cred I, 0.64–0.75) pregnancy were associated with reduced odds of attending the recommended minimum of four skilled ANC visits compared with wanted pregnancy. These likelihoods were even lower for at least one skilled ANC visit among women with a mistimed (aOR, 0.59, 95% Cred I, 0.53–0.65) or an unwanted pregnancy (aOR, 0.67, 95% Cred I, 0.61–0.74) than women with a wanted pregnancy.

Conclusions
In Bangladesh, more than one-quarter of women who report an unintended pregnancy at conception and do not terminate the pregnancy are at high risk of not using ANC. It is important for policies to include women with unintended pregnancy in mainstream healthcare services. This will increase the use of ANC and reduce associated adverse consequences.
Purification of high purity docosahexaenoic acid from Schizochytrium sp. SH103 using preparative-scale HPLC
Authors: Oh Chi-Eun , Kim Gap-Jin , Park Seung-Jin , Choi Seunghoon , Park Min-Joo , Lee O-Mi , Seo Jeong-Woo , Son Hong-Joo 
Published: September 2020

AbstractHigh purity polyunsaturated fatty acids (> 95%) are essential for the synthesis of specialized pro-resolving lipid mediators (SPMs), such as protectins, resolvins, and maresins, which are used for clinical application. To date, high purity (> 95%) eicosapentaenoic acid (EPA; C20:5n3) and docosahexaenoic acid (DHA; C22:6n3) have been produced through various manufacturing steps using fish oil. In this study, we optimized preparative high performance liquid chromatography (HPLC) process to purify high-purity DHA ethyl ester (DHAee; > 98%) from oleaginous microalgae Shizochytrium sp. SH103 containing at least 34% DHA content. The purity and yield of DHA were determined by reverse phase chromatography with changing the mobile phase velocity, loading amount, and mobile phase composition. On a semi-preparative scale, optimal DHA separation in isocratic elution was obtained with a mobile phase velocity of 0.5 mL/min, a loading amount of 10 mg/mL, and mobile phase composition of methanol/water (96:4, v/v), wherein the purity of DHA was 98.5%. This separation was scaled up to a preparative column, resulting in 99.0% DHA fraction with a yield of 79.8%. This result suggests that a large amount of high purity DHA can be produced from microalgae when scaling up a preparative column to an industrial column.
Containment of COVID-19 in Ethiopia and implications for tuberculosis care and research
Authors: Mohammed Hussen , Oljira Lemessa , Roba Kedir Teji , Yimer Getnet , Fekadu Abebaw , Manyazewal Tsegahun 
Published: September 2020

Abstract
Background
The coronavirus disease 2019 (COVID-19) has emerged as a global health and economic security threat with staggering cumulative incidence worldwide. Given the severity of projections, hospitals across the globe are creating additional critical care surge capacity and limiting patient routine access to care for other diseases like tuberculosis (TB). The outbreak fuels panic in sub-Saharan Africa where the healthcare system is fragile in withstanding the disease. Here, we looked over the COVID-19 containment measures in Ethiopia in context from reliable sources and put forth recommendations that leverage the health system response to COVID-19 and TB.

Main text
Ethiopia shares a major proportion of the global burden of infectious diseases, while the patterns of COVID-19 are still at an earlier stage of the epidemiology curve. The Ethiopian government exerted tremendous efforts to curb the disease. It limited public gatherings, ordered school closures, directed high-risk civil servants to work from home, and closed borders. It suspended flights to 120 countries and restricted mass transports. It declared a five-month national state of emergency and granted a pardon for 20 402 prisoners. It officially postponed parliamentary and presidential elections. It launched the ‘PM Abiy-Jack Ma initiative’, which supports African countries with COVID-19 diagnostics and infection prevention and control commodities. It expanded its COVID-19 testing capacity to 38 countrywide laboratories. Many institutions are made available to provide clinical care and quarantine. However, the outbreak still has the potential for greater loss of life in Ethiopia if the community is unable to shape the regular behavioral and sociocultural norms that would facilitate the spread of the disease. The government needs to keep cautious that irregular migrants would fuel the disease. A robust testing capacity is needed to figure out the actual status of the disease. The pandemic has reduced TB care and research activities significantly and these need due attention.

Conclusions
Ethiopia took several steps to detect, manage, and control COVID-19. More efforts are needed to increase testing capacity and bring about behavioral changes in the community. The country needs to put in place alternative options to mitigate interruptions of essential healthcare services and scientific researches of significant impact.
Frictional properties of anorthite (feldspar): implications for the lower boundary of the seismogenic zone
Authors: Masuda Koji 
Published: September 2020

AbstractEarthquake magnitude is closely related to the depth extent of the seismogenic zone, and higher magnitude earthquakes occur where the seismogenic zone is thicker. The frictional properties of the dominant mineral constituents of the crust, such as feldspar-group minerals, control the depth extent of the seismogenic zone. Here, the velocity dependence of the steady-state friction of anorthite, the calcic endmember of the feldspar mineral series, was measured at temperatures from 20 to 600 °C, pore pressures of 0 (“dry”) and 50 MPa (“wet”), and an effective pressure of 150 MPa. The results support previous findings that the frictional properties of feldspar play a dominant role in limiting the depth extent of the seismogenic zone. This evidence suggests that brittle deformation of anorthite may be responsible for brittle fault movements in the brittle–plastic transition zone.
Effect of 0.2% peracetic acid disinfection on the horizontal dimension of implant framework indexed with two autopolymerized acrylic resins
Authors: da Fonseca Emanuely Ronconi , Santana Paula Pereira , Xible Anuar Antonio , Curtis Donald A. , Kano Stefania Carvalho 
Published: September 2020

Abstract

Background
To minimize misfit between prosthesis and implant, the welding of the implant fixed partial denture (IFPD) framework is recommended and autopolymerized acrylic resin (AR) is the material of choice for the indexing process. As for any prosthetic device that comes into contact with saliva and blood in the oral cavity, IFPD indexed with AR must be disinfected before sending to the laboratory. However, disinfection procedures are often neglected for fear of shrinkage or distortion caused by a dimensional change of the acrylic resin. Peracetic acid is a high-level disinfectant agent at low concentrations and immersion time, with no reported toxic residues, and it is not inactivated in the presence of organic matter when compared to other disinfectants. This study aimed to evaluate the influence of 0.2% peracetic acid disinfectant solution after different storage media and times on the horizontal dimension of IFPD frameworks indexed with AR.

Material and methods
IFPD frameworks were indexed with two AR: group 1 Duralay and group 2 Pattern Resin LS. Each group was further divided into five subgroups according to disinfection procedure and storage medium: no disinfection and dry storage, no disinfection and water storage, 0.2% peracetic acid disinfection and water storage, 0.2% peracetic acid disinfection and peracetic acid storage, and 0.2% peracetic acid disinfection and dry storage. The horizontal dimension of the specimens and an average was established for analysis. Measurements were performed at four different storage times (hours): T0, T24, T48, T168.

Results
No statistical differences were found when T0 was compared to T168 for Pattern resin groups submitted to disinfection and storage in water (group 2b, p = 1.000) or peracetic acid solution (group 2c, p = 0.352). For Duralay groups, the use of peracetic acid solution did not affect the horizontal dimension of the specimens when T0 was compared to T168 only with water as a storage medium (group 1b, p = 1.000). Additionally, T0 did not differ from T24 for groups 1c (p = 0.553), 2b (p = 1.000), 2d (p = 0.234), and 2e (p = 1.000) and from T48 for groups 1d (p = 0.118) and 2b (p = 1.000).

Conclusion
Within the studied conditions, the use of 0.2% peracetic acid can be safely used as a disinfectant solution regarding dimensional stability of AR-indexed IFPD until 7 days of storage. Horizontal discrepancies are dependent on acrylic resin type, time, and medium of storage.