bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual and non‐visual properties of filters manipulating short‐wavelength light
Authors: Spitschan Manuel , Lazar Rafael , Cajochen Christian 
Published: November 2019

AbstractPurposeOptical filters and tints manipulating short‐wavelength light (sometimes called ‘blue‐blocking’ or ‘blue‐attenuating’ filters) are used in the management of a range of ocular, retinal, neurological and psychiatric disorders. In many cases, the only available quantification of the optical effects of a given optical filter is the spectral transmittance, which specifies the amount of light transmitted as a function of wavelength.MethodsWe propose a novel physiologically relevant and retinally referenced framework for quantifying the visual and non‐visual effects of these filters, incorporating the attenuation of luminance (luminous transmittance), the attenuation of melanopsin activation (melanopsin transmittance), the colour shift, and the reduction of the colour gamut (gamut reduction). Using these criteria, we examined a novel database of spectral transmittance functions of optical filters (n = 121) which were digitally extracted from a variety of sources.ResultsWe find a large diversity in the alteration of visual and non‐visual properties. The spectral transmittance properties of the examined filters vary widely, in terms of shapes and cut‐off wavelengths. All filters show relatively more melanopsin attenuation than luminance attenuation (lower melanopsin transmittance than luminous transmittance). Across the data set, we find that melanopsin transmittance and luminous transmittance are correlated.ConclusionsWe suggest that future studies and examinations of the physiological effects of optical filters quantify the visual and non‐visual effects of the filters beyond the spectral transmittance, which will eventually aid in developing a mechanistic understanding of how different filters affect physiology. We strongly discourage comparing the downstream effects of different filters on, e.g. sleep or circadian responses, without considering their effects on the retinal stimulus.
Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort
Authors: Bandoli Gretchen , Palmsten Kristin , Chambers Christina 
Published: November 2019

AbstractBackgroundPrevious studies of prenatal acetaminophen use have not addressed what indications and maternal co‐factors describe acetaminophen use.ObjectiveThe objective of this study was to describe these parameters in a well‐characterised, prospective birth cohort.MethodsData were drawn from the MotherToBaby study of pregnant women enrolled from 2004 to 2018. Daily acetaminophen diaries were calculated for all exposed women with complete dose and duration information. Descriptive statistics were used to assess maternal characteristics associated with acetaminophen use. Prevalence by 2‐year interval was described, and linear regression was used to test for trend. Indication of use and dose per indication were summarised.ResultsOf 2441 subjects, 1515 (62%) reported use of acetaminophen. Over the 15‐year period, there was a decline in use of 2.5% for each 2‐year period (test for trend = 0.001) with 58% reporting acetaminophen use in 2017‐2018. Among women with acetaminophen use in pregnancy (n = 1515), 58% reported <10 days of use, 13% reported 10‐19 days of use, 9% reported 20‐44 days of use, and 9% reported 45 or more days of use. Twelve per cent had undefined duration of use. Increasing duration of exposure was associated with tobacco use, obesity, self‐reported depression or anxiety, and antidepressant use. The most frequently reported indication was headache, however, indication varied by duration of use, with more women reporting use for sleep or pain/injury in the categories with the longest duration of use. Median dose per exposed day was highest among those reporting use for sleep, and higher doses were more frequently reported for arthritis, injury, and pain.ConclusionAcetaminophen is used by the majority of pregnant women, and some continue to use for many weeks in pregnancy. Given the heterogeneity in duration of use, indication, and dose, studies that estimate the risk of adverse outcomes associated with acetaminophen must carefully consider these factors.
Dietary protein requirements of fish – a meta‐analysis
Authors: Teles Aires Oliva , Couto Ana , Enes Paula , Peres Helena 
Published: November 2019

AbstractThere are hundreds of fish reared in aquaculture, but nutrient requirements of the different species are still scarcely studied. Dietary protein is usually one of the first nutrients to be evaluated when considering the nutritional requirements of a novel species for aquaculture. Data on dietary protein requirement are already available for a large number of species, and this study aims to review the available data, enhancing eventual differences due to species, feeding habits, fish size, rearing temperature and water salinity. Overall, dietary protein requirements in the different studies ranged between 24 and 70% of the diet, depending on species and life stanzas. Dietary protein requirements were directly related to fish trophic level and water salinity, and inversely related to rearing temperature. Dietary protein intake was linearly related to weight gain, while protein retention was not affected, averaging 187 g protein kg−1 weight gain. On average, fish require a protein intake of 624 g kg−1 weight gain and dietary protein retention efficiency is close to 32%.
The Hot Hand in Professional Darts
Authors: Ötting Marius , Langrock Roland , Deutscher Christian , Leos-Barajas Vianey 
Published: November 2019

SummaryWe investigate the hot hand hypothesis in professional darts in a nearly ideal setting with minimal to no interaction between players. Considering almost 1 year of tournament data, corresponding to 167492 dart throws in total, we use state space models to investigate serial dependence in throwing performance. In our models, a latent state process serves as a proxy for a player's underlying form, and we use auto-regressive processes to model how this process evolves over time. Our results regarding the persistence of the latent process indicate a weak hot hand effect, but the evidence is inconclusive.
Quantifying the HIV treatment cascade in a South African health sub‐district by gender: retrospective cohort study
Authors: Lurie Mark N. , Kirwa Kipruto , Callaway Julia , Cornell Morna , Boulle Andrew , Bengtson Angela M. , Smith Mariette , Leon Natalie , Colvin Christopher 
Published: November 2019

AbstractObjectivesTo quantify the HIV care cascade in a Cape Town sub‐district to understand rates of linkage to and engagement in HIV care.MethodsWe used routinely collected data to reconstruct the treatment cascade for 8382 infected individuals who tested HIV + in 2012/2013. We obtained data on patient gender, year of initial HIV‐positive test, age at testing and initial CD4 cell count and defined five stages of the HIV care cascade. We quantified attrition across cascade stages.ResultsTwo‐thirds of the sample (5646) were women. Men were older at time of first testing (36.5 vs. 31.3 years) and had more advanced HIV disease at diagnosis (298 vs. 404 CD4 cells/µL for women). The median duration of follow‐up was 818 days. Among women, 90.5% attended an initial HIV care visit, 54.6% became eligible for antiretroviral therapy under local guidelines during follow‐up, 49.3% initiated ART and 45.6% achieved a therapeutic response. Among men, 88.0% attended an initial HIV care visit, 67.4% became ART eligible during follow‐up, 48.0% initiated ART and 42.4% achieved a therapeutic response. Approximately 3% of women and 5% of men died during follow‐up.ConclusionsWe were able to reconstruct the HIV treatment cascade using routinely collected data. In this setting, rates of engagement in care differ by gender in key stages of the cascade, with men faring worse than women at each cascade point. This highlights the need for interventions aimed at encouraging earlier testing, linkage, ART initiation and retention among men.
Development of a mercury‐free ultraviolet high‐pressure plasma discharge for disinfection
Authors: Mayor‐Smith Ian , Templeton Michael R. 
Published: November 2019

AbstractUltraviolet (UV) disinfection is a critical and growing application for the disinfection of water. Current UV systems for disinfection applications are designed around the use of Low‐Pressure and High‐Pressure mercury‐based lamps. Increasing demand to reduce and ideally remove the use of mercury requires innovative adaptations and novel approaches to current technology. A potential alternative technology could be Light Emitting Diodes (LEDs), with current low efficiencies, high costs and low operating powers, a development gap for a high‐power mercury source has been identified. A mercury‐free tellurium‐based high‐pressure plasma was developed and assessed. Though relatively low efficiencies were measured compared to current mercury‐based technology rapid improvements are likely obtainable. Such an approach enables a novel adaptation to current technology utilising established: manufacturing facilities, approaches of UV system design and validation protocols. As a consequence, it offers the potential for a rapid low‐cost transition to mercury‐free UV disinfection where no alternative is currently available.
Ankle and Midfoot Power During Single-Limb Heel Rise in Healthy Adults
Authors: DiLiberto Frank E. , Nawoczenski Deborah A. 
Published: November 2019

Although the midfoot is recognized to have an important role in the successful performance of a single-limb heel rise, healthy heel rise performance remains primarily characterized by ankle function. The purpose of this study was to examine the contribution of midfoot region power to single-limb heel rise in healthy adults. Participants (N = 12) performed 20 single-limb heel rises. An electromagnetic motion capture system and a force plate were used to record 3-segment foot motion and ground reaction forces. Inverse dynamic calculations were performed to obtain ankle and midfoot region powers. These data were evaluated with descriptive statistics. A correlation was performed to evaluate the contribution of midfoot region power to heel height, as heel height is a clinical measure of heel-rise performance. The midfoot contributed power during single-limb heel rise (peak positive power: 0.5 [0.2] W·kg−1). Furthermore, midfoot peak power accounted for 36% of the variance in heel height (P = .04). As energy generating internal mechanisms, such as muscle activity, are attributed to power generation, midfoot tissue loading and muscle performance should be considered during clinical and modeling applications of the heel-rise task.
Geologic controls on up-dip and along-strike propagation of slip during subduction zone earthquakes from a high-resolution seismic reflection survey across the northern limit of slip during the 2010 Mw 8.8 Maule earthquake, offshore Chile
Authors: Tréhu Anne M. , Hass Bridget , de Moor Alexander , Maksymowicz Andrei , Contreras-Reyes Eduardo , Vera Emilio , Tryon Michael D. 
Published: November 2019

AbstractA grid of closely spaced, high-resolution multichannel seismic (MCS) reflection profiles was acquired in May 2012 over the outer accretionary prism up dip from the patch of greatest slip during the 2010 Mw 8.8 Maule earthquake (offshore Chile) to complement a natural-source seismic experiment designed to monitor the post-earthquake response of the outer accretionary prism. We describe the MCS data and discuss the implications for the response of the accretionary prism during the earthquake and for the long-term evolution of the margin. The most notable observation from the seismic reflection survey is a rapid north-to-south shift over a short distance from nearly total frontal accretion of the trench sediments to nearly total underthrusting of undeformed trench sediments that occurs near the northern edge of slip in the 2010 earthquake. Integrating our structural observations with other geological and geophysical observations, we conclude that sediment subduction beneath a shallow décollement is associated with propagation of slip to the trench during great earthquakes in this region. The lack of resolvable compressive deformation in the trench sediment along this segment of the margin indicates that the plate boundary here is very weak, which allowed the outer prism to shift seaward during the earthquake, driven by large slip down dip. The abrupt shift from sediment subduction to frontal accretion indicates a stepdown in the plate boundary fault, similar to the stepovers that commonly arrest slip propagation in strike-slip faults. We do not detect any variation along strike in the thickness or reflective character of the trench sediments adjacent to the change in deformation front structure. This change, however, is correlated with variations in the morphology and structure of the accretionary prism that extend as far as 40 km landward of the deformation front. We speculate that forearc structural heterogeneity is the result of subduction of an anomalously shallow or rough portion of plate that interacted with and deformed the overlying plate and is now deeply buried. This study highlights need for three-dimensional structural images to understand the interaction between geology and slip during subduction zone earthquakes.
mHealth tool to improve community health agent performance for child development: study protocol for a cluster-randomised controlled trial in Peru
Authors: Westgard Christopher Michael , Rivadeneyra Natalia , Mechael Patricia 
Published: November 2019

IntroductionCultivating child health and development creates long-term impact on the well-being of the individual and society. The Amazon of Peru has high levels of many risk factors that are associated with poor child development. The use of ‘community health agents’ (CHAs) has been shown to be a potential solution to improve child development outcomes. Additionally, mobile information and communication technology (ICT) can potentially increase the performance and impact of CHAs. However, there is a knowledge gap in how mobile ICT can be deployed to improve child development in low resource settings.Methods and analysisThe current study will evaluate the implementation and impact of a tablet-based application that intends to improve the performance of CHAs, thus improving the child-rearing practices of caregivers and ultimately child health and development indicators. The CHAs will use the app during their home visits to record child health indicators and present information, images and videos to teach key health messages. The impact will be evaluated through an experimental cluster randomised controlled trial. The clusters will be assigned to the intervention or control group based on a covariate-constrained randomisation method. The impact on child development scores, anaemia and chronic malnutrition will be assessed with an analysis of covariance. The secondary outcomes include knowledge of healthy child-rearing practices by caregivers, performance of CHAs and use of health services. The process evaluation will report on implementation outcomes. The study will be implemented in the Amazon region of Peru with children under 4. The results of the study will provide evidence on the potential of a mHealth tool to improve child health and development indicators in the region.Ethics and disseminationThe study received approval from National Hospital ‘San Bartolome’ Institutional Ethics Committee on 8 November 2018 (IRB Approval #15463–18) and will be disseminated via peer-reviewed publications.Trial registration numberISRCTN43591826.
Contribution of serum lipids as effect modifiers to a relationship between mean arterial pressure and coronary heart disease in Chinese rural population: the Henan Rural Cohort Study
Authors: Zhang Xia , Li Yuqian , Wang Yanhua , Hu Kai , Tu Runqi , Zhang Haiqing , Tian Zhongyan , Qiao Dou , Zhang Gongyuan , Wang Chongjian 
Published: November 2019

ObjectivesThe aim of this study was to evaluate the relationship between mean arterial pressure (MAP) and coronary heart disease (CHD) in Chinese rural population. In addition, we hypothesised that this relationship might be mediated by some degree of serum lipids.DesignThis is a cross-sectional study.SettingThe participants were from the Henan Rural Cohort Study, initiated in five rural areas (Tongxu county of Kaifeng city, Yima county of Sanmenxia city, Suiping county of Zhumadian city, Xinxiang county of Xinxiang city and Yuzhou county of Xuchang city) in Henan Province, China, during July 2015 and September 2017.ParticipantsThe study included 39 020 subjects aged 18–79 years as current research population.Outcome measuresSystolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using an electronic sphygmomanometer. MAP was calculated by one-third SBP plus two-thirds DBP. The study used restricted cubic splines and logistic regression models to evaluate the ORs and 95% CIs. Mediation analysis using bootstrap was performed to examine the contribution of serum lipids to MAP-related CHD.ResultsThe adjusted OR (95% CI) for the highest MAP quartile with the risk of CHD was 1.45 (1.24 to 1.69) compared with the lowest quartile. Simultaneously, each 1-SD increment in MAP was significantly associated with a 12% increased risk of CHD. A linear dose–response relationship between MAP and CHD was found (p value for non-linear=0.1169) in the fully adjusted model. We further reported that 36.07% of proportion explained risk of CHD was mediated through serum lipids.ConclusionsIncreased MAP was a significant marker of CHD in Chinese rural population. Meanwhile, the relationship was mediated by some degree of serum lipids, and triglyceride was the strongest mediator.Trial registration numberHenan Rural Cohort study has been registered at Chinese Clinical Trial Register (ChiCTR-OOC-15006699) and the stage it relates to is Post-results.
Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study
Authors: Liu Xiaoxuan , Kale Aditya Uday , Capewell Nicholas , Talbot Nicholas , Ahmed Sumiya , Keane Pearse A , Mollan Susan , Belli Antonio , Blanch Richard J , Veenith Tonny , Denniston Alastair K 
Published: November 2019

ObjectiveThis study aims to evaluate the feasibility of retinal imaging in critical care using a novel mobile optical coherence tomography (OCT) device. The Heidelberg SPECTRALIS FLEX module (Heidelberg Engineering, Heidelberg, Germany) is an OCT unit with a boom arm, enabling ocular OCT assessment in less mobile patients.DesignWe undertook an evaluation of the feasibility of using the SPECTRALIS FLEX for undertaking ocular OCT images in unconscious and critically ill patients.SettingThis study was conducted in the critical care unit of a large tertiary referral unit in the United Kingdom.Participants13 systemically unwell patients admitted to the critical care unit were purposively sampled to enable evaluation in patients with a range of clinical states.Outcome measuresThe primary outcome was the feasibility of acquiring clinically interpretable OCT scans on a consecutive series of patients. The standardised scanning protocol included macula-focused OCT, OCT optic nerve head (ONH), OCT angiography (OCTA) of the macula and ONH OCTA.ResultsOCT images from 13 patients were attempted. The success rates of each scan type are 84% for OCT macula, 76% for OCT ONH, 56% for OCTA macula and 36% for OCTA ONH. The overall mean success rate of scans per patient was 64% (95% CI 46% to 81%). Clinicians reported clinical value in 100% scans which were successfully obtained, including both ruling in and ruling out relevant ocular complications such as corneal thinning, macular oedema and optic disc swelling. The most common causes of failure to achieve clinically interpretable scans were inadequately sustained OCT alignment in delirious patients and a compromised ocular surface due to corneal exposure.ConclusionsThis prospective evaluation indicates the feasibility and potential clinical value of the SPECTRALIS FLEX OCT system on the critical care unit. Portable OCT systems have the potential to bring instrument-based ophthalmic assessment to critically ill patients, enabling detection and micron-level monitoring of ocular complications.
Usefulness of applying research reporting guidelines as Writing Aid software: a crossover randomised controlled trial
Authors: Hawwash Dana , Sharp Melissa K , Argaw Alemayehu , Kolsteren Patrick , Lachat Carl 
Published: November 2019

ObjectivesTo assess the intention of using a Writing Aid software, which integrates four research reporting guidelines (Consolidated Standards of Reporting Trials, Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Strengthening the Reporting of Observational Studies in Epidemiology and STrengthening the Reporting of Observational Studies in Epidemiology-nutritional epidemiology) and their Elaboration & Explanation (E&E) documents during the write-up of research in Microsoft Word compared with current practices.DesignTwo-arms crossover randomised controlled trial with no blinding and no washout period.SettingFace-to-face or online sessions.Participants54 (28 in arm 1 and 26 in arm 2) doctoral and postdoctoral researchers.InterventionsReporting guidelines and their E&E document were randomly administered as Writing Aid or as Word documents in a single 30 min to 1 hour session, with a short break before crossing over to the other study intervention.Primary and secondary outcomesUsing the Technology Acceptance Model, we assessed the primary outcome: the difference in the mean of intention of use; and secondary outcomes: the difference in mean perceived ease of use and perceived usefulness. The three outcomes were measured using questions with a 7-point Likert-scale. Secondary analysis using structural equation modelling (SEM) was applied to explore the relationships between the outcomes.ResultsNo significant difference in reported intention of use (mean difference and 95% CI 0.25 (–0.05 to 0.55), p=0.10), and perceived usefulness (mean difference and 95% CI 0.19 (–0.04 to 0.41), p=0.10). The Writing Aid performed significantly better than the word document on researchers’ perceived ease of use (mean difference and 95% CI 0.59 (0.29 to 0.89), p<0.001). In the SEM analysis, participants’ intention of using the tools was indirectly affected by perceived ease of use (beta 0.53 p=0.002).ConclusionsDespite no significant difference in the intention of use between the tools, administering reporting guidelines as Writing Aid is perceived as easier to use, offering a possibility to further explore its applicability to enhance reporting adherence.