bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second allogeneic hematopoietic stem cell transplantation in patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation
Authors: Choi Yunsuk , Choi Eun‐Ji , Lee Jung‐Hee , Lee Kyoo‐Hyung , Jo Jae‐Cheol , Park Han‐Seung , Lee Yoo Jin , Seol Miee , Lee Young‐Shin , Kang Young‐Ah , Jeon Mijin , Lee Je‐Hwan 
Published: December 2020

AbstractThe prognosis of patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) is dismal. We aimed to evaluate the outcomes and prognostic factors of the second HSCT (HSCT2) in acute leukemia patients relapsed after the first HSCT (HSCT1). We analyzed 80 patients who received HSCT2 for relapsed acute leukemia in two Korean institutes. All but four patients received HSCT2 from a donor other than matched sibling donor: an unrelated donor (URD) in 30 and a familial haploidentical donor (FHD) in 46. Forty‐four patients (55.0%) were in complete remission (CR) or CR with incomplete count recovery (CRi) at HSCT2, and the median time from HSCT1 to relapse was 9 months. The 2‐year overall survival (OS) and event‐free survival (EFS) were 21.0% and 17.5%, respectively. The outcomes were similar between URD and FHD. Multivariate analysis demonstrated that disease status (active disease vs. CR/CRi) at HSCT2 and remission duration after HSCT1 were independent prognostic factors for OS and EFS after HSCT2. HSCT2 from URD or FHD was feasible in patients with acute leukemia relapsed after allogeneic HSCT. Also, our study confirmed two critical prognostic factors; disease status at HSCT2 and remission duration after HSCT1.
HFS‐LightGBM: A machine learning model based on hybrid feature selection for classifying ICU patient readmissions
Authors: Qiu Yan , Ding Shuai , Yao Ningguang , Gu Dongxiao , Li Xiaojian 
Published: December 2020

AbstractCompared to patients readmitted to general wards, readmitted patients in the intensive care unit (ICU) are exposed to higher mortality rates and prolonged hospital stays. Moreover, the readmission of ICU patients brings pressing challenges for ICU management. Most models are devoted to identifying the risk factors and developing classification models that can predict whether ICU patients will be readmitted. Though these models are prominent, they do not provide estimates for the frequency of readmissions. This paper establishes a prediction model, hybrid feature selection‐LightGBM (HFS‐LightGBM), to evaluate the probability and frequency of ICU patient readmissions empirically. In terms of feature selection, a hybrid feature selection (HFS) algorithm for LightGBM combines the filter and wrapper methods. Pearson's correlation coefficient is employed in the filter procedure. Then we adopt the targeted LightGBM classifier along with the recursive feature elimination and cross‐validated (RFECV) to produce the optimal feature subset. Additionally, the hyperparameters of the HFS‐LightGBM are optimized. The HFS‐LightGBM is employed on the real‐world ICU dataset containing 1722 patients' electronic health records. This model outperforms the current prevailing readmission models. The identified frequency can assist doctors in making specific interventions for patients to reduce the ICU readmission rate.
Family Conflicts and Technology Use: The Voices of Grandmothers
Authors: Ivan Loredana , Nimrod Galit 
Published: December 2020

ObjectiveOur aim was to understand family conflicts, specifically those involving grandmothers, related to use of new communication technologies.BackgroundResearch shows that tension between family members in intergenerational contexts arises in relation to technology. This is especially common when attitudes toward technology differ among family members. Differing opinions around technology use create gaps in skills and perceived competence. Grandparents' voices about the challenges of perpetual connectivity in family settings are absent in the research on technology domestication and mediation.MethodTo fill this gap, semistructured group interviews were conducted with women in Canada, Colombia, Israel, Italy, Peru, Romania, and Spain. All women were aged 65 years and older, had grandchildren, and used information and communication technology (ICT).ResultsGrandmothers experienced conflicts when interacting with grandchildren due to ginability to recognize online threats. Asking for help in managing different applications could be a source of family conflicts. Embarrassment and unease is reduced when grandmothers call grandchildren for help, rather than receive assistance from their adult children. Conflictual moments also emerged around the use of ICT at family dinners or other gatherings, with grandmothers showing more tolerance in this context for grandchildren than for their adult children.ConclusionFamily conflicts over technology use may differ when involving adult children versus grandchildren.ImplicationsThe voices of grandmothers express the importance of permanent and affordable opportunities for people to receive assistance in technology use outside of family contexts.
Heparin locks with low and high concentration in haemodialysis patients: A systematic review and meta‐analysis
Authors: Tan Jiajia , Ning Tingting , Zhang Wenting , Qian Zhuru , Jiang Xuqin , Sun Ling , Wu Bin 
Published: December 2020

AbstractAimThere is no evidence‐based consensus on the optimal concentration for heparin locks; several randomized controlled trials (RCTs) have evaluated the concentration of heparin locks, yet the results remain inconsistent. We aimed to assess heparin locks with low and high concentration in haemodialysis patients.MethodsWe performed a systematic review and meta‐analysis of RCTs focusing on the concentration in heparin locks. Studies were identified by searching PUBMED, EMBASE, Science Direct, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI) and Wanfang databases (from inception to 15 March 2020). Summary risk ratios or mean differences with 95% confidence interval were calculated.ResultsA total of 370 patients with four RCTs were included. Heparin locks with 1000 U/ml could significantly reduce the activated partial thromboplastin time (APTT) compared with 5000 U/ml. No significant differences were seen in the occurrence of catheter‐related thrombosis, the length of catheter stay, the rates of bleeding and catheter occlusions between the two groups.ConclusionsLower concentrations in heparin lock are optimal for shortening APTT in haemodialysis patients; further studies are needed to elucidate the role of heparin concentration in the lock practice.
Genetic differentiation among populations of the blackfin goodea Goodea atripinnis (Cyprinodontiformes: Goodeidae): implications for its evolutionary history
Authors: Beltrán‐López Rosa Gabriela , Domínguez‐Domínguez Omar , Piller Kyle R. , Mejía‐Mojica Humberto , Mar‐Silva Adán Fernando , Doadrio Ignacio 
Published: December 2020

AbstractCentral Mexico is characterized by a complex topography that is the result of historic and contemporary tectonic and climatic factors. These events have influenced the evolutionary history of numerous freshwater fishes in the region. Nonetheless, recent studies have shown that life‐history traits and ecological characteristics of species may influence dispersal capabilities and the degree of genetic connectivity. Goodea (Cyprinodontiformes: Goodeidae) is one of the most widely distributed and environmentally tolerant genera of goodeids. In this study, the authors analysed variation in the mitochondrial cytochrome b gene to evaluate the phylogeographic relationships, genetic structure, genetic diversity and demographic history of Goodea from across its distribution range. They found low genetic differentiation and identified shared haplotypes among several regions. Geographic segregation was found in samples southwest and northeast of the Lower Lerma region, with some internal isolated groups showing phylogeographic differentiation and unique haplotypes. The AMOVA best explained genetic structure when grouped by haplogroups rather than when grouped by recognized biogeographic regions. Several regions showed null genetic diversity, raising the possibility of dispersal mediated by humans. Finally, Bayesian Skyline Plot analysis showed a population expansion for the Southwest haplogroup, except for the Armería population and sub‐group II of the Northeast haplogroup. All this suggests a recent colonization of Goodea atripinnis throughout some of the biogeographic regions currently inhabited by this species.
Transcriptome comparison of isotretinoin‐effective and isotretinoin‐ineffective severe acne vulgaris patients
Authors: Jiang Yuchen , Zhang Jie , Guo Hongen , Chen Qiaoping , Lai Wei , Zheng Yue 
Published: December 2020

AbstractBackgroundOral isotretinoin is the first‐line treatment of severe nodular acne. However, patients presenting ineffective or poor effective to oral isotretinoin are still a clinical problem, and its molecular genetic mechanisms remain unclear.AimsTo compare the transcriptome profiles of isotretinoin‐effective and isotretinoin‐ineffective severe acne vulgaris patients and analyze the potential physiological roles to better understand the mechanisms of isotretinoin efficacy differences.Patients/MethodsPeripheral blood of 43 patients with severe acne was collected before treatment. After 8‐week isotretinoin, patients presented effective and ineffective to isotretinoin treatment were selected and their pretreatment peripheral blood was analyzed. High‐throughput sequencing was used to detect gene expression profiles. Gene Ontology and KEGG were used to perform functional annotation and pathway enrichment analysis.ResultsTen acne patients (3 male and 7 female, age 31 ± 9.2) presented effectiveness by oral isotretinoin and 10 acne patients (4 male and 6 female, age 28 ± 7.7) presented ineffectiveness were included. Comparison of gene profiles of isotretinoin‐effective and isotretinoin‐ineffective patients revealed 2779 differentially expressed genes: 2723 upregulated and 56 downregulated. Differentially expressed genes were enriched in RNA degradation pathway, autophagy pathway, protein ubiquitination pathway, protein processing in endoplasmic reticulum pathway, T‐cell receptor signaling pathway, spliceosome pathway, mRNA surveillance pathway, cell cycle pathway, long‐term potentiation pathway, and FoxO signaling pathway.ConclusionTranscriptome expression differences not only participated in the acne pathogenesis, but also influenced the isotretinoin therapeutic effects. These findings might provide some evidence for exploring individualized therapy for acne patients.
Healthcare professionals' competence in stroke care pathways: A mixed‐methods systematic review
Authors: Jarva Erika , Mikkonen Kristina , Tuomikoski Anna‐Maria , Kääriäinen Maria , Meriläinen Merja , Karsikas Eevi , Koivunen Kirsi , Jounila‐Ilola Päivi , Oikarinen Anne 
Published: December 2020

AbstractBackgroundThe challenges of caring for stroke patients are growing due to population ageing and improved survival rates. Healthcare professionals' competence development in stroke care is a necessity to ensure high‐quality patient care.ObjectivesTo identify and describe the competence areas of healthcare professionals working in the stroke patient care pathway and factors influencing these competences.DesignA mixed‐methods systematic review.MethodsThe review was conducted according to the JBI guidelines and registered in the PROSPERO database (CRD42020204062). PRISMA checklist guided the review process. Relevant original studies were identified by searching four databases—CINAHL (EBSCO), PubMed, Scopus and Medic. After researcher consensus was reached, 32 studies were selected for inclusion and subjected to content analysis and data tabulation.ResultsCompetence in care processes, clinical competence, competence in using self‐management strategies, interaction skills, skills in acknowledging family and competence in integrating the available evidence base into patient care were identified as key competence areas. Organisation of services, specialisation in stroke care, continuous development and education, family and carer and training in oral care and cognitive rehabilitation were identified as factors that influence healthcare professionals' competence.ConclusionsDiverse clinical and interaction competencies are needed throughout the stroke care pathway, and various factors affect healthcare professionals' competence. Further research on healthcare professionals' stroke care competence will be needed to respond to changing healthcare demand.Relevance to clinical practiceWe recommend organisational support and formulation of stroke care patient guidelines in line with healthcare competence requirements. Focus should be added for nursing professions in developing interactive communication competence since nurses spend the majority of the time providing individual patient care. Also, organisations should integrate continuing training in specialised stroke care for healthcare professionals' competence development.
Impact of menstrual cycle phase and oral contraceptives on sleep and overnight memory consolidation
Authors: Plamberger Christina Paula , Van Wijk Helen Elisabeth , Kerschbaum Hubert , Pletzer Belinda Angela , Gruber Georg , Oberascher Karin , Dresler Martin , Hahn Michael Andreas , Hoedlmoser Kerstin 
Published: December 2020

AbstractSleep spindles benefit declarative memory consolidation and are considered to be a biological marker for general cognitive abilities. However, the impact of sexual hormones and hormonal oral contraceptives (OCs) on these relationships are less clear. Thus, we here investigated the influence of endogenous progesterone levels of naturally cycling women and women using OCs on nocturnal sleep and overnight memory consolidation. Nineteen healthy women using OCs (MAge = 21.4, SD = 2.1 years) were compared to 43 healthy women with a natural menstrual cycle (follicular phase: n = 16, MAge = 21.4, SD = 3.1 years; luteal phase: n = 27, MAge = 22.5, SD = 3.6 years). Sleep spindle density and salivary progesterone were measured during an adaptation and an experimental night. A word pair association task preceding the experimental night followed by two recalls (pre‐sleep and post‐sleep) was performed to test declarative memory performance. We found that memory performance improved overnight in all women. Interestingly, women using OCs (characterized by a low endogenous progesterone level but with very potent synthetic progestins) and naturally cycling women during the luteal phase (characterized by a high endogenous progesterone level) had a higher fast sleep spindle density compared to naturally cycling women during the follicular phase (characterized by a low endogenous progesterone level). Furthermore, we observed a positive correlation between endogenous progesterone level and fast spindle density in women during the luteal phase. Results suggest that the use of OCs and the menstrual cycle phase affects sleep spindles and therefore should be considered in further studies investigating sleep spindles and cognitive performance.
Preliminary assessment of large‐scale co‐culture of sandfish (Holothuria scabra) with the Babylon snail (Babylonia areolata) in earthen ponds and in raceways
Authors: Dobson Gregory T. , Duy Nguyen Dinh Quang , Southgate Paul C. 
Published: December 2020

AbstractHolothuria scabra (sandfish) and Babylonia areolata were trialed in two large‐scale co‐culture experiments. Experiment 1 assessed co‐culture in 4 × 400 m2 earthen ponds where Babylonia were cultured in a central pen at a density of 400 individuals/m2 with sandfish occupying the remaining pond space at 1.1 individuals/m2. Sandfish grew from 18.20 ± 6.67 g to 119.03 ± 17.74 g in 92 days and Babylonia (fed trash fish in both experiments) grew from 0.90 ± 0.38 g to 4.93 ± 1.44 g, but Babylonia growth was not increased in co‐culture compared to monoculture. Water and sediment quality varied between co‐culture and monoculture ponds. Neither showed clear improvement due to sandfish culture. Experiment 2 compared non‐segregated sandfish‐Babylonia co‐culture with Babylonia monoculture in 20 m2 concrete raceways. Sandfish were cultured at 2 individuals/m2 and Babylonia at 300 individuals/m2. Sandfish grew up to 1.91 g.day−1 with 100% survival. Babylonia weight gain was significantly greater in co‐culture raceways (3.35 ± 0.64 g over 61 days), which was double that of Babylonia in monoculture. Substrate total N was reduced by 20% in co‐culture compared with monoculture (p = .032). This provisional study of commercial scale sandfish‐Babylonia co‐culture demonstrates culture compatibility, providing a basis for further system development.
Retention, stability, iron bioavailability and sensory evaluation of extruded rice fortified with iron, folic acid and vitamin B12
Authors: Jyrwa Yvette Wilda , Palika Ravindranadh , Boddula Swetha , Boiroju Naveen Kumar , Madhari Radhika , Pullakhandam Raghu , Thingnganing Longvah 
Published: December 2020

AbstractFortification of rice with micronutrients using extrusion technology is considered a sustainable strategy to prevent nutritional deficiencies in general population. The objective of the present study is to assess the retention, stability and iron bioavailability from indigenously developed triple fortified rice (iron, folic acid and vitamin B12) during rinsing and different cooking methods. Further, we also assessed the acceptability of fortified rice in adult human volunteers. The retention of iron during rinsing with excess water was ≥90%, whereas folic acid and vitamin B12 levels were reduced by ~25% during rinsing. Watertight cooking of rice (in electric cooker or on flame) had no additional effect on the nutrient levels as compared with rinsed rice, implying their stability during cooking. However, cooking with excess water followed by decanting led to loss of 45% iron and ≥70% folic acid and vitamin B12. The dialyzable iron and ferritin synthesis in Caco‐2 cells was significantly (P < .01) higher from fortified rice compared with unfortified rice. In addition, inclusion of ascorbic acid significantly (P < .01) increased the iron bioavailability from the fortified rice. Triangle tests in adult human subjects revealed that there are no significant sensory differences among fortified and unfortified rice. Further, fortified rice consumption appears to bridge the gaps in dietary iron intake deficits in children and women of reproductive age. These results suggest that the iron‐, folic acid‐ and vitamin B12‐fortified rice has higher retention and stability of fortified nutrients and is acceptable for consumption in adult human volunteers.
Divergence and agreement on nutrient intake between the two food composition tables of Bangladesh
Authors: Ali Masum , Amin Md Ruhul 
Published: December 2020

AbstractIn Bangladesh, two food composition tables (FCTs) were published over two consecutive years, in 2012 and in 2013. When different databases are used to calculate nutrient intakes, assessment of divergence and agreements is required. This study aimed to compare the differences in nutrient intakes, to assess the similarities in nutrient intakes between the two FCTs, and to explore the factors that cause the difference in nutrient intakes, if any. A total sample of 40 households was taken from the Household Income Expenditure Survey of 2010. Adult male equivalent (AME) units were used to estimate weighted average intake. Weighted k statistics were used to assess agreements between the two FCTs. Although median intake of energy and energy‐yielding nutrients (protein, fats, and carbohydrates) were found statistically significant between the two databases, the differences were not large enough to have practical significance. Excellent agreements were found in energy and carbohydrates with good for fats and fair for protein. However, statistically significant median percent differences were seen in beta carotene (441%), vitamin B6 (153%), and folate (129%), vitamin C (106%), zinc (101%), and iron (41%) intakes. For thiamin, iron, calcium, and phosphorous, more than 50% of the subjects were found in the same quintile, whereas nine out of 15 vitamins and minerals were misclassified into the opposite quintiles (≥10%). Fair agreements were found for most of the micronutrients. Variations in analytical methods and sources of nutrient information were the main contributing factors for actual differences. FCT data should be interpreted with caution, especially for micronutrients.
Relationships between land tenure insecurity, agrobiodiversity, and dietary diversity of women of reproductive age: Evidence from Acholi and Teso subregions of Uganda
Authors: Ekesa Beatrice , Ariong Richard M. , Kennedy Gina , Baganizi Mary , Dolan Ian 
Published: December 2020

AbstractLand tenure security is central to food security of rural agricultural‐dependent communities, but there is limited evidence linking the state of agrobiodiversity to perception of land tenure security and access to and quality of food eaten. This study explores this relationship using data captured from 1,279 households in Acholi and Teso subregions of Uganda, and the relationships are established using a study sample of 1,227 women of reproductive age (WRA). Sixteen percent of respondents perceived themselves to be land tenure insecure. Although approximately 275 species were reported available for food, household access to a variety of plant and animal species is limited to <10 species by 69% of the study population. Dietary diversity was also low, with 53% of women meeting minimum diet diversity. Evidence from estimation of a generalized Poisson regression reveals that dietary diversity of WRA is consistently, positively correlated with species diversity available for food and negative with land tenure insecurity. A unit increase in species diversity led to 18% increase in dietary diversity of WRAs. Land tenure insecurity was likely to reduce dietary diversity of WRAs by 26% (p < .05). Interventions with an aim to increase species diversity can deliver positive dividends for food and nutrition security. Land policy reforms and interventions that strengthen land tenure security for both men and women are likely to contribute positively to dietary diversity leading to improved food and nutrition security of vulnerable communities in rural areas.
Linkages of agroecosystems producing farmed seafood on food security, nutritional status and adolescent health in Bangladesh
Authors: de Roos Baukje , Roos Nanna , Ara Gulshan , Ahmed Tahmeed , Mamun Abdullah‐Al , Sneddon Alan A. , Murray Francis , Grieve Eleanor , Little David C. 
Published: December 2020

AbstractThis narrative review aims to provide an interdisciplinary perspective on actors that link global aquatic food production systems with fish consumption and nutritional status, with a special focus on adolescent girls in Bangladesh. The writing of this narrative perspective was undertaken within the framework of the Aquatic Food for Health and Nutrition (AQN) project that aimed to develop a metric for assessing the impacts on nutrition and health of agroecosystems producing farmed seafood. Previous studies evaluating links between agricultural ecosystems, aquaculture, food security and human health have systemically ignored the importance of diet and nutrition. Such studies have also ignored the importance of local communities, cultural norms and household composition and behaviours to identify vulnerable groups such as adolescent girls. This narrative review presents our current understanding of the relationships between aquaculture, fish production and consumption patterns, food security, optimal nutrition and health. It also highlights the importance of research into aquaculture food systems, linking aquatic food production systems with nutritional status, health and socioeconomic prosperity, which would help to develop more integrated and relevant food policies.