bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food-Borne Exposure of Juvenile Rainbow Trout (Oncorhynchus mykiss) to Benzotriazole Ultraviolet Stabilizers Alone and in Mixture Induces Specific Transcriptional Changes
Authors: Giraudo Maeva , Colson Tash-Lynn L. , De Silva Amila O. , Lu Zhe , Gagnon Pierre , Brown Lorraine , Houde Magali 
Published: January 2020

Abstract
Benzotriazole ultraviolet-stabilizers (BZT-UVs) are commonly used as additives to protect from light-induced degradation in a variety of consumer goods. Despite their widespread presence in aquatic ecosystems, information on the effects of these compounds remains largely unknown. The objectives of the present study were to evaluate the chronic effects of 2 BZT-UVs alone and in a mixture, 2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol (UV-234) and 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV-328), in juvenile rainbow trout (Oncorhynchus mykiss) chronically exposed (for 28 d) through the diet. Chemical analyses of livers from exposed trout suggested liver accumulation and potential metabolism of the 2 compounds. Hepatic RNA-sequencing analyses revealed specific effects of each compound on gene transcription profiles; UV-234 affected mainly genes involved in cellular metabolism, whereas UV-328 induced the transcription of ribosomal proteins and downregulated genes involved in immune responses. Both compounds regulated iron homeostasis genes in an opposite manner. The mixture of both BZT-UVs did not produce significant evidence of additive or synergistic effects. Environ Toxicol Chem 2020;39:852–862. © 2020 Her Majesty the Queen in Right of Canada. Environmental Toxicology and Chemistry © 2020 SETAC
Abstract
Benzotriazole ultraviolet (UV) stabilizers UV-234 and UV-328 induce transcriptional changes in juvenile rainbow trout exposed chronically through the diet, mainly affecting genes involved in iron homeostasis. ALB1 = serum albumin; AMBP = α-1-microglobulin; Fe = iron; HPX = hemopexin; TRF = transferrin.
Generation and Electron‐Transfer Reactivity of the Long‐Lived Photoexcited State of a Manganese(IV)‐Oxo‐Scandium Nitrate Complex
Authors: Sharma Namita , Lee Yong‐Min , Nam Wonwoo , Fukuzumi Shunichi 
Published: January 2020

AbstractPhotoexcitation of a manganese(IV)‐oxo‐scandium nitrate complex ([(Bn‐TPEN)MnIV(O)]2+−Sc(NO3)3) in a solvent mixture of trifluoroethanol and acetonitrile (v/v=1 : 1) resulted in generation of the long‐lived photoexcited state, which is detected by nanosecond laser transient absorption measurements. The transient absorption maximum (λmax) of the 2E excited state of [(Bn‐TPEN)MnIV(O)]2+−Sc(NO3)3 is observed at 620 nm with lifetimes of 7.1 μs. The λmax value is blue‐shifted and the lifetime becomes longer as compared with the previously reported values of λmax (640 nm) and lifetime (6.4 μs) of the 2E excited state of the 1 : 2 complex between [(Bn‐TPEN)MnIV(O)]2+ and Sc(OTf)3 ([(Bn‐TPEN)MnIV(O)]2+−(Sc(OTf)3)2). The electron‐transfer reactivity of the 2E excited states of [(Bn‐TPEN)MnIV(O)]2+−Sc(NO3)3 was similar to that of [(Bn‐TPEN)MnIV(O)]2+−(Sc(OTf)3)2. The long lifetime and the high reactivity of the 2E excited state of [(Bn‐TPEN)MnIV(O)]2+−Sc(NO3)3 provide an excellent photooxidant for oxidation of compounds, which would otherwise be impossible to be oxidized.
Establishment of thromboelastography reference intervals by indirect method and relevant factor analyses
Authors: Cheng Daye , Li Xiaoying , Zhao Shuo , Hao Yiwen 
Published: January 2020

AbstractThromboelastography (TEG) as a global coagulation test has been continuously developed for many decades in either research or clinical practice. The versatility of TEG test leads to difficulty in standardization and result interpretation. Reference intervals (RIs) of TEG may be one of the most controversial factors that influence its wide applications. RIs establishment with the traditional method is time‐consuming and laborious as well as beyond general laboratory capability. Indirect method using stored data and with statistical calculation and small cost is emerging as an alternative approach for RIs determination. Gender, age, or both affect RIs and must be taken into account before RIs estimation. The present study retrospectively collected a total of 930 TEG results as subjects and established RIs with indirect method for Kaolin‐activated TEG, including the parameters of R, K, αAngle, MA, and CI. Furthermore, gender, age, and gender‐dependent age subsets analyses were performed to determine their effects on RIs of TEG. In this study, we found that TEG parameters showed more hypercoagulability in female than male, most of the measured TEG variables were significantly associated with aging, but only in male statistical significance was found among different age stratification and 60‐year‐old could be considered as cutting point to differentiate coagulation ability in male. In addition, RIs of TEG were estimated by indirect method suitably and verified to be valid in our study. Finally, the RIs of TEG by indirect method were basically significantly different to the RIs recommended by manufacturer, but the consistent percentage is relatively high in the most of measured parameters. In conclusion, it is suggestive that the indirect method for RIs establishment is feasible, but relevant factors, such as gender and age, specifically gender‐dependent age effect, should be considered before RIs determinations.
Does sense of threat in civilians during an armed conflict predict subsequent depression symptoms?
Authors: Goral Aviva , Greene Talya , Gelkopf Marc 
Published: January 2020

AbstractObjectiveWe aimed to assess whether peritraumatic threat experienced during a period of armed conflict predicted subsequent depression symptoms.MethodNinety‐six Israeli civilians provided real‐time reports of exposure to rocket warning sirens and subjective sense of threat, twice daily for 30 days, during the 2014 Israel–Gaza conflict. Depression symptoms were reported 2 months after the conflict. Mixed‐effects models were used to estimate peritraumatic threat levels and peritraumatic threat reactivity (within‐person elevations in threat following siren exposure). These were then assessed as predictors of depression symptoms at 2 months in an adjusted regression model.ResultsIndividual peritraumatic threat level, but not peritraumatic threat reactivity, was a significant predictor of 2 months depression symptoms, even after controlling for baseline depression symptoms.ConclusionsThe findings imply that in situations of ongoing exposure, screening for perceived levels of peritraumatic threat might be useful in identifying those at risk for developing subsequent depression symptoms.
SOX2‐induced upregulation of lncRNA LINC01561 promotes non‐small‐cell lung carcinoma progression by sponging miR‐760 to modulate SHCBP1 expression
Authors: Gao Wei , Qi Chao‐Qun , Feng Mao‐Guo , Yang Peng , Liu Li , Sun Shu‐Hong 
Published: January 2020

AbstractLong noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumorigenesis. lncRNA LINC01561 (LINC01561) is a newly identified tumor‐related lncRNA and its dysregulation has been demonstrated in several tumors. However, whether LINC01561 is involved in the progression of non‐small‐cell lung carcinoma (NSCLC) and its underlying mechanisms remain unknown. In this study, we first provided evidence that LINC01561 expressions were distinctly upregulated in NSCLC tissues and cell lines. Combining with bioinformatics assays and mechanism experiments, our group demonstrated that LINC01561 was activated by SOX2 in NSCLC. Clinical research revealed that upregulation of LINC01561 was related to poorer clinicopathologic features and shorter survival time. Functionally, suppression of LINC01561 exhibited tumor‐suppressive functions through impairing cell proliferation, migration, and invasion as well as inducing apoptosis. Moreover, we verified that LINC01561 could directly bind to miR‐760, isolating miR‐760 from its target gene SHC SH2 domain‐binding protein 1 (SHCBP1). We also found that SHCBP1 was lowly expressed in NSCLC and served as a tumor promoter. A functional study indicated that LINC01561 regulated SHCBP1 expression by competitively binding to miR‐760. In summary, our findings indicated that SOX2‐induced overexpression of LINC01561 promoted the proliferation and metastasis by acting as a competing endogenous RNA to modulate SHCBP1 by sponging miR‐760.
Molecular structure, expression, and functional role of Clec11a in skeletal biology and cancers
Authors: Wang Miao , Guo Jianmin , Zhang Lingli , Kuek Vincent , Xu Jiake , Zou Jun 
Published: January 2020

AbstractC‐type lectin domain family 11 member A (Clec11a), also known as stem cell growth factor (SCGF), C‐type lectin superfamily member 3 (CLECSF3), or osteolectin was initially identified as a growth factor for hematopoietic progenitor cells. The human Clec11a gene encodes a polypeptide of 323 amino acids with characteristics of a secreted glycoprotein encompassing two integrin‐binding motifs, RGD (Arg‐Gly‐Asp) and LDT (Leu‐Asp‐Thr), a putative leucine zipper domain, and a functional C‐type lectin domain. It regulates hematopoietic differentiation and homeostasis and exhibits a protective effect against severe malarial anemia and lipotoxicity. Furthermore, Clec11a promotes the differentiation of mesenchymal progenitors into mature osteoblasts in vitro and plays an important role in the maintenance of adult skeleton age‐related bone loss and fracture repair. Receptor ligand binding results in activation of downstream signaling cascades including glycogen synthase kinase 3 (GSK3), β‐catenin, and Wnt, resulting in the expression of osteoblast‐related gene transcripts including Alp, Runx2, Lef1, and Axin2. In addition, Clec11a is also associated with the development of several cancers, including leukemia, multiple myeloma, and gastrointestinal tract tumors. To date, however, the mechanisms governing transcription regulation of the Clec11a gene are not known and remain to be uncovered. Understanding the function and mechanism of action of Clec11a will pave the way for the development of Clec11a as a novel therapeutic target for conditions such as cancer, anemia, and skeletal diseases.
Solution of mediated bioelectrocatalysis process related to the Michaelis‐Menten equation by sinc method
Authors: Nabati Mohammad , Jalalvand Mehdi , Daneh‐Dezfuli Alireza R. 
Published: January 2020

AbstractIn this study, sinc‐Galerkin and Sinc collocation methods coupled with double exponential transformation have been developed to obtain a numerical solution of nonlinear two‐point boundary value problem arising in steady state nonlinear reaction diffusion equation containing a nonlinear term related to Michaelis‐Menten of the enzymatic reaction. Application of these methods reduce the solution of the Michaelis‐Menten equation to the solution of nonlinear system of algebraic equations. The upper bound of the error was calculated. Two problems of this model, chosen from the literature, were considered and for several parameters, numerical solution was shown. Obtained numerical results and error of the methods show that these methods are very fast with high efficiency in convergence.
Drug burden index, polypharmacy and patient health outcomes in cognitively intact older residents of aged care facilities in Malaysia
Authors: Hasan S. S. , Chang S. H. , Thiruchelvam K. , Chong D. W. K. , Babar Z. U. 
Published: January 2020

AbstractBackgroundThe complexity of drug regimens among older people tend to increase over time, as multiple medications are required to treat a single condition.AimThis study examined the association of the drug burden index (DBI) and polypharmacy with patient health outcomes among cognitively intact older residents in aged care facilities (ACFs).MethodsA review of prescribed medications and related outcomes was conducted in a cross‐sectional sample of older adults (≥60 years), recruited from 11 ACFs in Peninsular Malaysia. Frailty and quality of life (QoL) were evaluated using the Groningen frailty indicator and ‘Older People's Quality of Life – 35’ questionnaire, respectively; patients’ exposure to anticholinergic and sedative medicines was quantified using the DBI; and the mental health of residents was evaluated using the Hospital Anxiety and Depression Scale.ResultsMore than two‐thirds of a sampled population received at least one anticholinergic or sedative medication and more than one‐quarter was exposed to polypharmacy. Exposure to DBI‐associated medications was noted in three of every four frail participants and was significantly correlated with frailty (r = 0.184, p = 0.023). The frail population had significantly increased risk of polypharmacy (odds ratio 6.07; 95% confidence interval 1.71–21.56; p = 0.005), but exposure to DBI‐associated medications was not significantly associated with overall QoL and activity of daily living measures.ConclusionPolypharmacy and anticholinergic and sedative burden were noticed in a substantial number of older adults in residential aged care facilities and were associated with frailty. Investing in the recruitment of pharmacists may benefit recognition of residential ACF quality of care, because pharmacy services (including pharmacists) are virtually non‐existent in Malaysian residential ACFs.
Preparative isolation and purification of 12 main antioxidants from the roots of Polygonum multiflorum Thunb. using high‐speed countercurrent chromatography and preparative HPLC guided by 1,1′‐diphenyl‐2‐picrylhydrazyl‐HPLC
Authors: Liu Minzhuo , Li Xujie , Liu Qi , Xie Siqi , Zhu Fawei , Chen Xiaoqing 
Published: January 2020

AbstractA hyphenated strategy by off‐line coupling of 1,1′‐diphenyl‐2‐picrylhydrazyl‐high‐performance liquid chromatography, high‐speed countercurrent chromatography, and preparative high‐performance liquid chromatography was established to screen and separate antioxidants from ethyl acetate fraction of the roots of Polygonum multiflorum. Under the targeted guidance of 1,1′‐diphenyl‐2‐picrylhydrazyl‐high‐performance liquid chromatography experiment, 12 compounds were identified as potential antioxidants and readily isolated by high‐speed counter‐current chromatography and preparative high‐performance liquid chromatography. Ultraviolet spectroscopy, mass spectrometry, and 1H NMR spectroscopy were employed to identify their structures, which were assigned as gallic acid (1, 6.2 mg, 98.28%), catechin (2, 8.8 mg, 90.69%), epicatechin (3, 4.1 mg, 96.71%), polydatin (4, 5.3 mg, 94.91%), 2,3,5,4′‐tetrahydroxy stilbene‐2‐Ο‐β‐D‐glucoside (5, 20.2 mg, 95.23%), piceatannol (6, 5.3 mg, 96.85%), rutin (7, 5.4 mg, 97.92%), resveratrol (8, 5.2 mg, 96.94%), isorhapontigenin (9, 11.4 mg, 94.81%), hyperoside (10, 9.7 mg, 98.52%), rhein (11, 4.9 mg, 97.46%), and emodin (12, 8.2 mg, 95.74%). Notably, compounds 6 and 9 were isolated from Polygonum multiflorum for the first time. In addition, antioxidant activity of compounds 1–12 were evaluated, and compounds 1–8 and 10 exhibited stronger antioxidant activity than ascorbic acid (positive control). These results indicated that the proposed method is a highly efficient strategy to screen and isolate antioxidants from complex natural products.
Automated assessment of psychiatric disorders using speech: A systematic review
Authors: Low Daniel M. , Bentley Kate H. , Ghosh Satrajit S. 
Published: January 2020

AbstractObjectiveThere are many barriers to accessing mental health assessments including cost and stigma. Even when individuals receive professional care, assessments are intermittent and may be limited partly due to the episodic nature of psychiatric symptoms. Therefore, machine‐learning technology using speech samples obtained in the clinic or remotely could one day be a biomarker to improve diagnosis and treatment. To date, reviews have only focused on using acoustic features from speech to detect depression and schizophrenia. Here, we present the first systematic review of studies using speech for automated assessments across a broader range of psychiatric disorders.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines. We included studies from the last 10 years using speech to identify the presence or severity of disorders within the Diagnostic and Statistical Manual of Mental Disorders (DSM‐5). For each study, we describe sample size, clinical evaluation method, speech‐eliciting tasks, machine learning methodology, performance, and other relevant findings.Results1395 studies were screened of which 127 studies met the inclusion criteria. The majority of studies were on depression, schizophrenia, and bipolar disorder, and the remaining on post‐traumatic stress disorder, anxiety disorders, and eating disorders. 63% of studies built machine learning predictive models, and the remaining 37% performed null‐hypothesis testing only. We provide an online database with our search results and synthesize how acoustic features appear in each disorder.ConclusionSpeech processing technology could aid mental health assessments, but there are many obstacles to overcome, especially the need for comprehensive transdiagnostic and longitudinal studies. Given the diverse types of data sets, feature extraction, computational methodologies, and evaluation criteria, we provide guidelines for both acquiring data and building machine learning models with a focus on testing hypotheses, open science, reproducibility, and generalizability.Level of Evidence3a
Experimental study on the tribological behaviour of CeO2‐diesel blends on the injector body
Authors: Yin Bifeng , Kuang Xin , Xu Bo , Jia Hekun , Hua Xijun 
Published: January 2020

AbstractThis paper aims to evaluate the impact of different qualities of nano‐cerium dioxide (CeO2) as the diesel additives on the friction and wear performance of the fuel injection system. Two different qualities of nano‐CeO2 were selected to prepare stably dispersed CeO2‐diesel blends. Their effects on the tribological behaviour of the injector body were studied on the RTEC friction tester. The results showed that the friction and wear properties of diesel blend with 10 ppm of CeO2 (whether CeO2‐1 or CeO2‐2) were all improved compared with pure diesel. With the increase of CeO2 addition (>10 ppm), the friction coefficient, wear width, and maximum wear depth of the wear scar increased. Compared with the blocky CeO2, adding spherical CeO2 into diesel had better friction and wear properties. Adding 10 ppm of CeO2 to diesel has no negative impact on the friction and wear performance of the injector body, especially the spherical CeO2.
Geodesic orbit and naturally reductive nilmanifolds associated with graphs
Authors: Nikolayevsky Y. 
Published: January 2020

AbstractWe study Riemannian nilmanifolds associated with graphs. We prove that such a nilmanifold is geodesic orbit if and only if it is naturally reductive if and only if its defining graph is the disjoint union of complete graphs and the left‐invariant metric is generated by a certain naturally defined inner product.
A critical role for Akt1 signaling in acute pancreatitis progression†
Authors: Sarker Rim SJ , Steiger Katja 
Published: January 2020

AbstractAcute pancreatitis (AP) is an inflammatory disease of the pancreas that causes significant morbidity and mortality worldwide. Unfortunately, there is no specific treatment available to date. Several studies have previously shown that inhibitors of the PI3K/Akt axis downregulate the degree of inflammation in animal models of AP. However, studies on in vivo side‐effects of such inhibitors are still lacking. In a recent issue of The Journal of Pathology, Chen, Malagola et al investigated if inhibition of Akt signaling plays a negative role in the regenerative phase of AP. They showed that treating AP mice with an Akt inhibitor (MK2206) impaired acinar regeneration and increased the development of acinar‐to‐ductal metaplasia. This is the first study to highlight the negative impact of an Akt inhibitor on cellular regeneration while simultaneously inhibiting inflammation in AP. The authors also suggested combining Akt activators to recover pancreatic regeneration. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Maternal low body mass index is a risk factor for fetal ductal constriction following indomethacin use among women undergoing fetal repair of spina bifida
Authors: Nassr Ahmed A. , Furtun Betul Y. , Sanz Cortes Magdalena , Erfani Hadi , Whitehead William E. , Donado Mayel Y. , Olutoye Olutoyin , Velez Mario P. , Espinoza Jimmy , Belfort Michael A. , Shamshirsaz Alireza A. 
Published: January 2020

AbstractObjectivesThe objectives were to determine the prevalence of and to identify risk factors associated with constriction of the fetal ductus arteriosus (DA) following perioperative indomethacin use for fetal myelomeningocele (MMC) repair.Study designA retrospective chart review study included 100 consecutive fetuses who underwent fetal MMC repair between 2011 and 2018. All patients had fetal echocardiography (FE) on postoperative day (POD)#1 and 2 to detect constriction of the DA. All patients received indomethacin for tocolysis using a standardized protocol. Multivariate regression analysis was carried out to identify the predictors for fetal ductal constriction.ResultsEighty patients met our study eligibility criteria. Median gestational age at time of surgery was 25 (24‐25) weeks. Constriction of the DA was detected in 14 fetuses (17.5%). In five fetuses, this was observed on POD# 1, in seven on POD# 2, and in two on both days. The only independent risk factor for predicting DA constriction was maternal body mass index (BMI) <25 kg/m2 (P = .002).ConclusionIndomethacin therapy following fetal MMC surgery requires careful daily FE surveillance. The association of DA constriction and low BMI suggests that BMI‐based dosing of indomethacin may be recommended for perioperative tocolysis in fetal MMC surgery.