bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation
Authors: Yang Fuchun , Sun Shaogang , Wang Chenran , Haas Michael , Yeo Syn , Guan Jun-Lin 
Published: April 2020

Abstract
Backgound
The mechanistic target of rapamycin complex 1 (mTORC1) is important in the development and progression of many cancers. Targeted cancer therapy using mTORC1 inhibitors is used for treatment of cancers; however, their clinical efficacies are still limited.

Methods
We recently created a new mouse model for human lymphangiosarcoma by deleting Tsc1 in endothelial cells and consequent hyper-activation of mTORC1. Using Tsc1iΔEC tumour cells from this mouse model, we assessed the efficacies of histone deacetylase (HDAC) inhibitors as anti-tumour agents for mTORC1-driven tumours.

Results
Unlike the cytostatic effect of mTORC1 inhibitors, HDAC inhibitors induced Tsc1iΔEC tumour cell death in vitro and their growth in vivo. Analysis of several HDAC inhibitors suggested stronger anti-tumour activity of class I HDAC inhibitor than class IIa or class IIb inhibitors, but these or pan HDAC inhibitor SAHA did not affect mTORC1 activation in these cells. Moreover, HDAC inhibitor-induced cell death required elevated autophagy, but was not affected by disrupting caspase-dependent apoptosis pathways. We also observed increased reactive oxygen species and endoplasmic reticulum stress in SAHA-treated tumour cells, suggesting their contribution to autophagic cell death, which were dependent on mTORC1 hyper-activation.

Conclusion
These studies suggest a potential new treatment strategy for mTORC1-driven cancers like lymphangiosarcoma through an alternative mechanism.
Pregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women: a registry-based study
Authors: Sköld Camilla , Bjørge Tone , Ekbom Anders , Engeland Anders , Gissler Mika , Grotmol Tom , Madanat-Harjuoja Laura , Ording Anne Gulbech , Trabert Britton , Tretli Steinar , Troisi Rebecca , Sørensen Henrik Toft , Glimelius Ingrid 
Published: April 2020

Abstract
Background
Non-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian cancer, their associations with SCSTs and GCTs remains unclear.

Methods
Using data from the medical birth registries from Denmark, Finland, Norway and Sweden, we compared all parous women with a diagnosis of SCSTs (n = 420) or GCTs (n = 345) 1970–2013 with up to 10 parous controls (SCSTs n = 4041; GCTs n = 2942) matched on the cases’ birth year and country. We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of associations between pregnancy-related factors and SCSTs and GCTs.

Results
The risk of SCSTs, but not GCTs, decreased with higher age at last birth [≥40 versus <25 years: OR 0.48 (95% CI 0.23–0.98)]. The risk of SCSTs (but not GCTs) also decreased with shorter time since last birth. Number of births, preterm birth, preeclampsia, and offspring size were not associated with risk of SCSTs or GCTs.

Conclusions
We found a decreased risk of SCSTs with higher age at last birth and shorter time since last birth. The risk of SCSTs (but not GCTs) may be influenced by the woman’s reproductive history.
Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery
Authors: Pal Pragya Paramita , Shaik Ameer Basha , Begum A. Sajeli 
Published: April 2020

AbstractA wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained
from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.
EFFECTIVENESS OF AN INFORMATION BOOKLET ON HOME REMEDIAL MEASURES FOR BREAST ENGORGEMENT
Authors: Eapen Sherin Sara , Philomena Fernandes 
Published: April 2020

AbstractThe study was conducted to evaluate the effectiveness of an information booklet on Home remedial measures for breast engorgement among postnatal mothers. An evaluative approach with one group Pre test Post test design was used for the study. 40 samples were selected using simple random sampling method. The present study was conducted in Justice K. S. Hegde Charitable hospital Mangalore. The collected data were analysed using descriptive and inferential statistics. A significant difference between Pre test and Post test knowledge was found (t=14.788,p<0.05). The study findings showed that the information booklet was highly effective in improving knowledge of the postnatal mothers by providing an information booklet on home remedial measures for breast engorgement. There was no significant association between the level of knowledge and demographic variables such as age, residing area, educational status, source of information, occupational status, parity.
USING MULTIPLE ASSESSORS TO EVALUATE CORE COMPETENCIES OF NURSING STUDENTS: A 360° EVALUATION APPROACH
Authors: R. Hemalatha , Shakuntala B S 
Published: April 2020

AbstractTraditional student evaluations have always been by the teaching faculty with less or no input from the nurses, patients, peers or even student's self. The objective of our study was to use 360 degree feedback in the evaluation of core competencies of final year nursing students and compare the ratings of RN, patients, peers and self rating of student. 374 final year students of selected nursing colleges in Bangalore and Tumkur were enrolled for the study. Patients, RN, peers and students themselves completed evaluator-specific evaluations in the first week of clinical period by using a validated 3 point rating scale of 40 items for both the peer and self and 21 and 20 items for the patients and RN respectively. Mean scores were tallied for each domain and for the total scale. Agreement between the raters was done using Pearson's correlation coefficient. A total of 1496 evaluations were completed for 374 samples. The mean item score ranged from 4.86 to 5.17 across all competency domains. The overall mean rating score for self, peer, client and RN was 43.7(SD 3.16), 43.6 (SD 2.34), 20.6 (SD 1.65) and 20.2 (SD 1.83) respectively. The self and peer ratings of the students were higher than the ratings of RN's and patients. None of the students were at the novice level. The Pearson's correlation coefficient between peer and self evaluation was statistically significant(r=0.28; p at 0.01 level). There was a weak but statistically significant positive relationship between peer and RN evaluation(r=0.11; p at 0.05 level). As different raters rated the students differently there was no significant relationship between self, patient, and RN ratings. This study finds potential value in the use of 360 degree evaluation of nursing students in both the hospital and community settings.
DENTAL CARIES AND FLUORIDE LEVELS IN WATER AND MILK IN 13-15 YEAR OLD ADOLESCENT POPULATION IN DAKSHINA KANNADA DISTRICT, INDIA
Authors: Hegde Mithra N. , Punja Ashwitha , Bhat Ganesh , Mahale Uday S. 
Published: April 2020

Abstract
Introduction
Dental caries is an infectious microbiological disease affecting all age groups. Fluoride slows down the progression of an existing carious lesion thus reducing the incidence of dental caries. World Health Organisation (WHO) recommends 0.5 to 1 ppm fluoride content in community water supply and milk fluoridation in case of non-feasibility of community water fluoridation. The aim of present study was to determine fluoride levels in water and milk in Dakshina Kannada District and to co-relate them with the DMFT scores in13-15 year old adolescent population.
Methodology
Water samples were collected from six different regions and sources from Dakshina Kannada District. Water samples were tested for fluoride content by ion specific electrode. A school dental survey was conducted to determine different brands of milk consumed by the children and their DMFT index. Milk samples were tested for fluoride levels by Ion Specific electrode using TSAB-II solution. DMFT scores were correlated with fluoride level of milk consumed by population. Interobesrver reliability by kappa statistics and association test with one way ANOVA was done.
Results
The range of fluoride levels in waters samples was 0.01 to 0.17 ppm and that of milk samples was 0.176 to 1.38 ppm. There was no much difference in fluoride levels of different milk sources. Hence association between DMFT and milk fluoride levels was not statistically significant (p=0.2).
Conclusion
Negligible amounts of Fluoride levels were found in water and milk. There is scope to conduct milk or water fluoridation programme in South Kannada District as a caries prevention method.
STUDY OF BIO-MEDICAL WASTE GENERATION AND MANAGEMENT IN VARIOUS HOSPITALS IN DAVANGERE CITY OF KARNATAKA, INDIA
Authors: Thirumala S. 
Published: April 2020

AbstractThis research article is to survey the practice of biomedical waste such as collection, storage, transportation and disposal along with the amount of generated biomedical waste in various hospitals in Davangere city, and create awareness among the staff and patient about biomedical wastes. The survey result on biomedical waste generation, disposal and methods adopted in various hospitals of Davangere city are discussed.
A STUDY ON THE EFFECT OF PLACENTAL CORD DRAINAGE ON THE DURATION OF THIRD STAGE OF LABOUR AMONG INTRANATAL WOMEN IN A SELECTED HOSPITAL AT MANGALORE
Authors: Joseph Taniya , Nayak Sabitha 
Published: April 2020

AbstractThe study was conducted to assess the effect of placental cord drainage on the duration of third stage of labour among intra natal women. The study design adopted was true experimental approach with two group post-test only research design. The base line clinical Proforma were used to collect the data from the womem in control and experimental group. Data obtained in these areas were analysed rd by descriptive and inferential statistics. The study finding also revealed that there is a significant difference between the duration of 3rd stage of labour among experimental group and control group. & there is no significant association between the duration of third stage of labour and selected demographic variables among experimental group and control group.
KAP STUDY OF FACTORS PROMOTING BREASTFEEDING IN NURSING MOTHERS AND PREGNANT WOMEN
Authors: Shetty Sharanya B. , K. Sudarshan Shetty 
Published: April 2020

Abstract
Background: Breastfeeding is known to be central in an infant's nutrition and growth worldwide. Fewer mothers offer breast milk in this crucial period due to various misconceptions and cultural beliefs. Our objective was to assess the knowledge, attitude and practice of breast feeding and identify misconceptions regarding breast feeding practices in suburban south Indian town.
Methodology: Observational study conducted in a tertiary teaching hospital of coastal south India. A total of 300 subjects including pregnant and nursing mothers attending the outpatient departments were recruited. Subjects were briefed orally, consent taken and a structured questionnaire administered by a single observer. Mothers who were unable to breast feed due to medical contraindications were excluded. The data was analysed using SPSS software. Univariate and binary regression analyses were performed for associations.
Results: Among the subjects 36% had primary education and 12% were graduates. Majority (61%) lived in a joint family. Only 52.3% of the subjects received advice on breastfeeding during antenatal visits, out of which only 19.3% had a breast examination. 58.7% knew that breastfeeding should be initiated within 1 hour of child birth but only 48% of the mothers who had delivered initiated breastfeeding within 1 hour. 71.6% of the mothers knew that exclusive breastfeeding should be practised for 6 months. On univariate analysis mothers with more than 1 child, vaginal delivery and an educated partner had awareness of breastfeeding and practiced healthy breastfeeding.
Conclusion: Our study emphasises the need to counsel mothers regarding breastfeeding practices early during antenatal visits and not postpone till after delivery, include the spouse for support, sensitise the health care giver and improve infrastructure for a successful breastfeeding initiation.
PREVALENCE OF CANDIDA ASSOCIATED DENTURE STOMATITIS (CADS) AND SPECIATION OF CANDIDA AMONG COMPLETE DENTURE WEARERS OF SOUTH WEST COASTAL REGION OF KARNATAKA
Authors: Bhat Vinaya , Sharma S.M. , Shetty Veena , Shastry C.S. , Rao Vaman , Shenoy Shilpa M. , Saha Santanu , Balaji Sriram 
Published: April 2020

AbstractA denture wearer is highly prone to develop Candida associated denture stomatitis (CADS), due to the conversion of the normal oral commensal Candida spp. into a pathogen under favorable conditions. Immuno-compromised status, trauma from the prosthesis, other systemic conditions and improper maintenance of the dentures by the patient are few of the causative agents which turn the oral balance into an unhealthy and unsuitable foundation for the wearing of the prosthesis. Prevalence of denture stomatitis caused by the fungi Candida has been identified worldwide and has been reported to be around 65 to 70% of the denture wearers. The main species that causes infection has been Candida albicans, however, recently, there is a shift to non-Candida albicans-Candida (NCAC).This cross-sectional survey was undertaken to find the prevalence of denture stomatitis and the causative species in the south westcoastal region of Karnataka.
A PILOT STUDY ON KNOWLEDGE & PRACTICE REGARDING PREVENTION OF OCCUPATIONAL HAZARDS AND ATTITUDE TOWARDS UTILISATION OF SAFETY MEASURES AMONG FISHERMEN WORKING AT A SELECTED HA. B.R
Authors: Rodrigues Devina E. , Kiran Udaya 
Published: April 2020

AbstractA pilot study was conducted to assess the knowledge, practice on occupational hazards and attitude towards utilization of safety measures among fishermen at Malpe fishing harbor from 5-8-2012 to19-8-2012.The descriptive survey study was conducted among 40 fishermen. Convenient sampling technique was used in selection of sample. The data was collected by face to face interview using structured knowledge questionnaire with 30 items on knowledge on occupational hazards, 3 point scale to elicit the self reported practices in prevention of occupational hazards and by 5 point likert scale to determine the attitude towards utilization of safety measures. The overall knowledge indicated that 55% of the subjects had inadequate knowledge and rest had adequate knowledge related to work related hazards. In the area of psycho-social the subjects had adequate knowledge (63%, SD 1.05); the least possession of knowledge was in the area of safety devices (47.5%). Fishermen had moderately adequate practices (55.29%) and area wise practice score had revealed that subjects had poor practices concerning personal protective devices. Attitude found to be moderate among fishermen (95%).There was significant relationship between knowledge and practice score(r= 0.366, df= 38, P= 0.304) as well as practice and attitude scores(r = 0.370) at 0.05 level of significance. Found no correlation between knowledge and attitude scores. The study highlights the need to inspire the fishermen to improve their safety at work place and develop positive attitude about utilization of safety devices.
FACIAL ARTERY ON FACE - A STUDY ON SOUTH INDIAN CADAVERS AND SPECIMENS
Authors: Quadros Lydia S. , Babu Arathy , D'souza Antony Sylvan 
Published: April 2020

Abstract
Context: Facial artery is usually the main artery supplying the face. It gives three named branches on the face, the inferior labial, the superior labial and the lateral nasal and continues as the angular artery. Face is also supplied by the transverse facial artery and the arteries accompanying the cutaneous nerves.
Aim: In the present study, variations of facial artery on face were observed.
Settings & design: Department of Anatomy, Kasturba Medical College, Manipal.
Material & method: The present study was performed on 38 males and 12 females' formalin-fixed hemi-faces. Diameter of facial artery was noted at two specific points using a fine microcaliper.
Results: The variations were divided into 3 categories. Out of 38 male hemi-faces, 100% right and 78% left hemi-faces belonged to type I category; 22% left hemi-faces belonged to Type III category. Out of 12 female hemi-faces, 80% right and 80% left hemi-faces belonged to Type I category, 18% left hemi-faces belonged to Type II category and 20% right and 2% left hemi-faces belonged to Type III category. Premasseteric branch was observed in 4 hemi-faces; a duplex with a prominent lateral angular branch was observed in 4 hemi-faces and anenlarged transverse facial artery was seen in 2 hemi-faces. The diameter of facial artery at its origin and at the antero-inferior angle of masseter muscle was larger in males.
Conclusion: This study shows that the variations in the branches and the diameter of the facial artery were relatively larger in males when compared to females.
HEALTH SEEKING BEHAVIOR OF RURAL ADULTS
Authors: Dominic Rose Ann , N. Shashidhara Y. , Nayak Malathi G. 
Published: April 2020

Abstract
Background: The knowledge of health seeking behavior is pivotal for prevention, treatment, management of disease and promotion of health. Proper understanding of those health seeking behaviors could reduce delay to diagnosis, improve treatment compliance and improve health promotion strategies in a variety of contexts.
Objectives: to assess the health seeking behavior among rural adults towards private and public health care facilities in case of selected health problems, to find the association between health seeking behavior and selected demographic variables.
Materials and Methods: A descriptive survey was done among 260 rural adults by using self administered rating scale questionnaire. Descriptive and inferential statistics were used for the analysis.
Results: Among the 260 samples 28.8% were having positive health seeking behavior towards government health care facilities. Majority of the sample i.e. 71.2% were having negative health seeking behavior towards government health care facilities. There is a significant association between health seeking behavior and demographic variables such as age, education and family income.
Conclusion: Majority of the sample prefers to use private health care facilities during the period of their illness. Awareness to be given to the community people regarding availability of public health care facilities.
IN VIVO ANALYSIS OF LIPID PEROXIDATION AND TOTAL ANTIOXIDANT STATUS IN SUBJECTS TREATED WITH STAINLESS STEEL ORTHODONTIC APPLIANCES
Authors: Quadras Dilip Daniel , Nayak U.S. Krishna , N. Suchetha Kumari , Pujari Prashant , R. Vijay , Dethose Ajay 
Published: April 2020

Abstract
Introduction: Nickel is a strong immunologic sensitizer, although nickel sensitivity has been reported to be lower in subjects who have received orthodontic treatment; perhaps they develop immunological tolerance over the long period of treatment. Hence the present aim of the work was to determine the levels of lipid peroxidation and total antioxidant status in Serum and Saliva in subjects treated with stainless steel Orthodontic appliances.
Methods and Materials: The study group included 25 participants and Samples were taken in different time intervals: Time interval 1- Collection of samples before the appliances fixed, Time interval 2- Collection of sample after one week of fixed appliances, Time interval 3- Collection of sample after three months of fixed appliances each from the Orthodontic Department of A. B.Shetty Memorial institute of dental science.Lipid peroxidation (Malondialdehyde) level is estimated using Thiobarbituric acid (TBA) method. Total antioxidant level was estimated using Phosphomolybdenum method.
Conclusion: Total antioxidant and Malondialdehyde levels are increased in case of Females compared to Males in serum whereas in case of Saliva Total antioxidant level is increased in Time interval 2 and 3 in Males compared to Females.
A STUDY TO ASSESS THE TFFECTIVENESS OF PLANNED TEACHING PROGRAMME (PTP) ON POLYCYSTIC OVARIAN SYNDROME (PCOS) AMONG ADOLESCENT GIRLS IN SELECTED HIGH SCHOOLS AT MANGALORE
Authors: D'Souza Pramila 
Published: April 2020

AbstractA study was done to assess the effectiveness of planned teaching programme (PTP) on polycystic ovarian syndrome (PCOS) among adolescent girls in selected high schools at Mangalore. The main objectives of the study were1. To assess the pre-test level of knowledge regarding PCOS among adolescent girls in Selected high schools at Mangalore.2. To evaluate the effectiveness of Planned Teaching Programme on knowledge regarding Polycystic Ovarian Syndrome among adolescent girls in selected high schools at Mangalore.3. To find the association between the pre-test knowledge score of adolescent girls and selected variables.An evaluatory approach with pre-experimental one group pre-test post-test design was used for the study. The subjects were 100 adolescent girls selected by convenience sampling technique. PTP was administered after the assessment of pre-intervention knowledge on PCOS. Post intervention knowledge was assessed on the 7th day of the administration of PTP through the same structured knowledge questionnaire. The results of this study in general showed, the significant difference between the mean pre-test and posttest knowledge score (t99=7.02, p<0.05).The significant difference was found in between all the areas. There was no association between the pre-test knowledge score and selected demographic variables. Hence it can be concluded that PTP was effective in gaining knowledge of adolescent girls on PCOS. which was evident in post-test knowledge score.