bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pro-neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease
Authors: Tönjes Anke , Hoffmann Annett , Kralisch Susan , Qureshi Abdul Rashid , Klöting Nora , Scholz Markus , Schleinitz Dorit , Bachmann Anette , Kratzsch Jürgen , Nowicki Marcin , Paeschke Sabine , Wirkner Kerstin , Enzenbach Cornelia , Baber Ronny , Beige Joachim , Anders Matthias , Bast Ingolf , Blüher Matthias , Kovacs Peter , Löffler Markus , Zhang Ming-Zhi , Harris Raymond C. , Stenvinkel Peter , Stumvoll Michael , Fasshauer Mathias , Ebert Thomas 
Published: June 2020

Background:
Patients with chronic kidney disease (CKD) have a high risk of premature cardiovascular diseases (CVD) and show increased mortality. Pro-neurotensin (Pro-NT) was associated with metabolic diseases and predicted incident CVD and mortality. However, Pro-NT regulation in CKD and its potential role linking CKD and mortality have not been investigated, so far.

Methods:
In a central lab, circulating Pro-NT was quantified in three independent cohorts comprising 4715 participants (cohort 1: patients with CKD; cohort 2: general population study; and cohort 3: non-diabetic population study). Urinary Pro-NT was assessed in part of the patients from cohort 1. In a 4th independent cohort, serum Pro-NT was further related to mortality in patients with advanced CKD. Tissue-specific Nts expression was further investigated in two mouse models of diabetic CKD and compared to non-diabetic control mice.

Results:
Pro-NT significantly increased with deteriorating renal function (P < 0.001). In meta-analysis of cohorts 1–3, Pro-NT was significantly and independently associated with estimated glomerular filtration rate (P ≤ 0.002). Patients in the middle/high Pro-NT tertiles at baseline had a higher all-cause mortality compared to the low Pro-NT tertile (Hazard ratio: 2.11, P = 0.046). Mice with severe diabetic CKD did not show increased Nts mRNA expression in different tissues compared to control animals.

Conclusions:
Circulating Pro-NT is associated with impaired renal function in independent cohorts comprising 4715 subjects and is related to all-cause mortality in patients with end-stage kidney disease. Our human and rodent data are in accordance with the hypotheses that Pro-NT is eliminated by the kidneys and could potentially contribute to increased mortality observed in patients with CKD.
Effect of sex and sex steroids on brown adipose tissue heat production in humans
Authors: Fuller-Jackson John-Paul , Dordevic Aimee L , Clarke Iain J , Henry Belinda A 
Published: June 2020

Objective:
Retrospective studies suggest that women have more active brown adipose tissue (BAT) than men, but little is known of the effect of fluctuating sex steroids across the menstrual cycle on thermogenesis in women.

Design:
To characterise the effects of sex and sex steroids on BAT activity we recruited healthy weight men (n = 14) and women at two stages of the menstrual cycle (luteal, n = 9; follicular, n = 11).

Methods:
Infrared thermography measured supraclavicular temperature to index BAT thermogenesis in response to both cold (immersion of one hand in water at 15°C) and meal (Ensure, 10 kcal/kg body weight) stimuli.

Results:
Adaptive BAT temperature responses were greater (P < 0.05) in women than men, irrespective of stage of menstrual cycle. Whereas during cold exposure, the increase in BAT temperature was abrogated (P < 0.05) in women during follicular phase compared to men and women during luteal phase. Plasma concentrations of progesterone, 17β-estradiol, testosterone and cortisol were measured. Regression analyses demonstrated that baseline BAT temperature was positively correlated (P < 0.05) with progesterone levels, but was inversely associated (P < 0.05) with cortisol concentration. Both cold- and meal-induced changes in BAT temperature mildly correlated (P = 0.07; P < 0.05) with 17β-estradiol levels, but not with testosterone concentrations.

Conclusions:
Baseline supraclavicular temperature is elevated in women during the luteal phase of the menstrual cycle, which correlated with elevated progesterone concentrations. Women exhibited greater thermogenic responses than men, irrespective of the state of the menstrual cycle, which was associated with plasma levels of 17β-estradiol. We conclude that sex steroids may regulate BAT thermogenesis in healthy adults.
Evaluación de la presencia de Adenocephalus pacificus en pescados de mayor consumo en el Perú en el periodo 2016-2017
Authors: Londoñe-Bailón Pablo , Céspedes-Chombo Roxana , Díaz Pereyra Katherine 
Published: June 2020

El presente estudio tuvo como objetivo evaluar la prevalencia, abundancia e intensidad media de plerocercoides (PLs) de Adenocephalus pacificus en pescados de mayor importancia comercial de la costa peruana. Se muestrearon 28 especies de pescados y se analizaron 12 017 especímenes. Se determinó la presencia de PLs de A. pacificus a partir de anchoveta (Engraulis ringens), lorna (Sciaena deliciosa), lisa (Mugil cephalus), caballa (Scomber japonicus), cabrilla (Paralabrax humeralis) y cabinza (Isacia conceptionis) con una prevalencia de 0.55, 24.96, 0.56, 1.79, 1.53 y 3.94%, respectivamente. Tres distintos tipos de escólex de PLs de A. pacificus fueron identificados como esférico, lanceolado y acorazonado, indistintamente del hospedero, zona y periodo de muestreo.
EVALUATION OF BLOOD PROCESSED BY CELL SAVER IN PEDIATRIC SCOLIOSIS
Authors: García Elena , Rey Pilar del , Martínez Ernesto 
Published: June 2020

Introduction:We study the hematological and microbiological characteristics from the autologous
blood processed through the intraoperative cell saver used in our centre (Orthopat®) during the
correction of pediatric scoliosis, which is known to be a potentially bleeding surgery.
Material and methods: Descriptive analysis of 31 patients undergoing pediatric scoliosis surgery. All
of them received blood processed by cell saver intraoperatively. The variables collected were:
demographic data, volume of the autogenous red blood cell (RBC) concentrate, blood count,
biochemistry, blood culture, preoperative and postoperative blood tests of the patients, incidence
of fever during reinfusion of RBC concentrate, postoperative surgical site infections and length of
hospital stay.
Results: Average volume obtained 288.06ml (sd 154.68). Hematocrit 70.38% (sd 10.03) in
accordance with cell-saver commercial data (75%). Of the blood samples obtained, 42.86% had
blood cultures that were positive for aerobes and 48.28% for anaerobes. The relation between
postoperative infections and contamination of blood concentrates was not statistically significant.
When comparing the pre-surgery and post-surgery analytical samples, statistically significant
differences (p <0.05) were found in the following: hemoglobin and hematocrit decreased in the
postoperative period, while coagulation parameters show a tendency to coagulopathy.
Conclusion: Our cell saver obtains RBC concentrates with a percentage of hematocrit in agreement
with available information. The reinfusion of them is safe from an infectious and biochemical point
of view, but its immunological implications are not clear. This surgery continues to result in a
significant loss of blood. Measures taken to avoid allogenic transfusions remain necessary and
should be enhanced.
Collusion or Critique?
Authors: Tully Tyler M. 
Published: June 2020

While a variety of sources explore the character of Mary Magdalene and her popularly conceived configurations throughout history (Maisch 1998; King 2003, 2006; Jean-Yves 2002; Mead 2005; Kiely 2010), little attention has been paid to her representation in the Gospel of Luke, specifically her scant exorcism and possession narratives. Drawing upon contemporary archaeological insights and historical and textual sources, this article reconstructs an image of Mary before exploring her presentation in the canonical and non-canonical accounts of the first two centuries CE. Working with similar methodologies pioneered by Stephen D. Moore (Moore 2004) and Virginia Burrus (Burrus 2009), in conversation with Mary L. Keller’s (Keller 2002, 2015) theoretical framework of spirit possession, this article investigates the possession and exorcism narratives of Mary Magdalene in Luke’s gospel from a postcolonial optic.
Oral Language Proficiency in Distance English-Language Learning
Authors: Marcum Jared , Kim Yanghee 
Published: June 2020

Online learning environments are changing the landscape of education, with evidence supporting their efficacy (Means, Toyama, Murphy, Bakia, & Jones, 2009). However, research that focuses entirely on online distance English-language programs is sparse, especially in regards to oral proficiency. The purpose of this study is to investigate the efficacy of an online distance-learning program in helping students develop oral English-language proficiency as they prepare to attend a university in the United States. The curriculum for the distance-learning program was built upon Moore’s (1993) transactional distance theory, with an emphasis on interpersonal dialogue as a key tool in promoting oral proficiency. Students participated in synchronous and asynchronous interaction with fellow students, tutors, and their instructors. The American Council on the Teaching of Foreign Languages (ACTFL) computer-assisted Oral Proficiency Interview (OPIc) provided the pretest and posttest measures for this study. To supplement this data, course surveys provided information concerning student opinions of course activities. OPIc results showed that students made significant gains in their oral proficiency from pretest to posttest. In surveys, students rated interaction with other tutors and teachers as instrumental in assisting them with their language learning, but rated interaction with their peers as less helpful.
Free vibration of a 2D-FGSW beam based on a shear deformation theory
Authors: Ninh Vu Thi An , Anh Le Thi Ngoc , Kien Nguyen Dinh 
Published: June 2020

A two-dimensional functionally graded sandwich (2D-FGSW) beam model\break formed from three constituent materials is proposed and its free vibration is studied for the first time. The beam consists of three layers, a homogeneous core and two functionally graded skin layers with material properties varying in both the length and thickness directions by power gradation laws. Based on a third-order shear deformation theory, a beam element using the transverse shear rotation as an independent variable is formulated and employed in the study. The obtained numerical result reveals that the variation of the material properties in the length direction plays an important role on the natural frequencies and vibration modes of the beam. The effects of the material distribution and layer thickness ratio on the vibration characteristics are investigated in detail. The influence of the aspect ratio on the frequencies is also examined and discussed.
Malignant and premalignant lesions of the tongue, clinical and histopathological findings for their early detection. Study of two cases
Authors: Martinez-Martinez Adel , Diaz-Caballero Antonio , Quintero-Echenique Natalia 
Published: June 2020

Background: Squamous cell carcinoma affects subjects between the sixth and seventh decade of life. However, there are growing reports on the involvement of young adults.
Clinical Cases: Two male patients aged 40 and 55, with no history of tobacco consumption and occasional alcohol consumption. They presented an exophytic ulcer and a white plaque on the lateral border of the tongue, the first diagnosed as moderately differentiated squamous cell carcinoma without HPV DNA genotypes and the second as leukoplakia without dysplasia.
Conclusions: Risk factors commonly associated with potentially malign disorders and oral cancer, such as smoking and alcohol consumption, were not involved in the present cases. Therefore identify clinical, histopathological and molecular findings, allows the early detection of them, improving the prognosis of these patients.
Síndrome de Klippel Trenaunay Weber en el embarazo. Reporte de caso y revisión de literatura
Authors: Paniagua-Coahuila Carlos Arturo , Martínez-Martínez Crescencio , Arellano-Hernández José Luis , Alonso-Lozano Dulce Alejandra , Mendoza-Hernández Freddy , Mendieta Zerón Hugo 
Published: June 2020

Introducción: El síndrome de Klippel-Trenaunay (SKT) es un trastorno congénito que se caracteriza por la presencia de nevo cutáneo vascular, malformaciones venosas e hipertrofia de tejidos blandos y huesos que afectan una o más extremidades
Caso clínico: Una mujer de 20 años, primípara, diagnosticada con SKT desde la infancia, fue atendida a las 34 semanas de gestación con múltiples várices cervicales y vulvares y la presencia de un nevo vasculocutáneo en el miembro pélvico derecho; Se realizó angiorresonancia de contraste, donde se confirmaron múltiples malformaciones arteriovenosas a nivel de la extremidad pélvica derecha, comprometiendo la región inguinal, vulvar, femoral y discretamente el segmento uterino. El tratamiento con heparina de bajo peso molecular se inició hasta que se suspendió 24 horas antes de la programación de la cesárea a las 39,1 semanas de gestación.
Discusión: Se obtuvo un recién nacido sin complicaciones con sangrado transquirúrgico de 450 ml. Se fue a su casa 48 horas después de la cirugía sin evidencia de complicaciones y posterior seguimiento en una clínica ambulatoria de angiología y medicina crítica obstétrica.
Analysis of clinical manifestations and diagnosis of late-onset myasthenia gravis
Authors: Khalmurzina A. N. , Alekseeva T. M. , Lobzin S. V. , Rudenko D. I. , Kryuchkova V. V. 
Published: June 2020

Introduction. Myasthenia gravis is one of the most common autoimmune neuromuscular diseases, the peak incidence is in the age of 20–40 years. However, studies show that throughout the world in recent decades there has been an increase in the prevalence and incidence of myasthenia gravis among older people.Purpose of the study – to evaluate the clinical manifestations and diagnostic features of myasthenia gravis in patients with an onset of diseases in the elderly.Materials and methods. The retrospective, non-interventional study included 315 patients over 18 years old with a reliable (3 out of 4 criteria) and an undoubted (4 out of 4 criteria) diagnosis of myasthenia gravis, the duration of the disease for up to 5 years, undergoing inpatient treatment from 2001 to 2017 years. The severity of the clinical manifestations of myasthenia gravis was assessed using the Myasthenia Gravis Foundation of America scale. We were taken into account the information about the first symptoms, duration of the period from the onset of the disease to the verification of the diagnosis, results of the examinations, the presence of concomitant diseases and treatment methods.Results. The most common symptom of myasthenia gravis in the group of patients with debut disease aged 60 years and older was ptosis (p <0.001). The crises and pathology of the thymus were less common in elderly patients (p <0.0001). The concentration of antibodies to acetylcholine receptors was the same (p = 0.05) among all patients. The level of antibodies to titin was increased in patients with lateonset (p = 0.0014). The presence of bronchopulmonary pathology made worse the course of myasthenia gravis in elderly people (p = 0.01), while cardiovascular and cerebrovascular diseases, as well as diabetes mellitus, did not occur (p >0.005). At the first examination in the group of elderly patients among the incorrectly diagnoses prevailed: stroke or decompensation of chronic cerebral ischemia (p = 0.0002). With a comparable duration and severity of myasthenia gravis in different age groups, the combination of anticholinesterase drugs, glucocorticosteroids and azathioprine (p = 0.01) at a lower daily dose (100 mg) was more often used for the treatment of elderly patients compared with young and middle-aged groups (150 mg) (p = 0.03).Conclusion. Diagnosis of myasthenia gravis in elderly patients presents the greatest difficulties, and symptoms of manifestation during initial treatment are often regarded as a manifestation of vascular pathology. Despite the presence of concomitant diseases characteristic of this age group, myasthenia gravis does not differ in the severity of the course. To achieve remission and compensation of symptoms, elderly patients do not need large doses of symptomatic and pathogenetic drugs.
Knowledge and awareness among nursing students regarding the COVID-19: a cross sectional study
Authors: Joshi K. P. , Madhura Leena , Jamadar Deepak 
Published: June 2020

Background: The health care providers are at the front line of the outbreak response of current pandemic of COVID-19 and exposed to hazards that put them at risk of infection. Rapid spread of the COVID-19 pandemic has become a major cause of concern for the healthcare profession in all over the world. All health care professional must stay aware of the latest information on the COVID-19 outbreak. This research paper deals with the knowledge and awareness about COVID-19 among nursing students.Methods: By non-probability snowball sampling method the sample size was 407. Predesigned and pretested questionnaire was used in this study. Questions were related to knowledge and awareness about current COVID-19. The participant was directed to complete the self-report survey by online. The data was tabulated and analysed statistically. MS-Excel and Statistical Package for Social Sciences version 22.0 used for all statistical analysis.Results: A total of 407 nursing students participated in this study. Over all 75.58±3.21 participants showed good knowledge and awareness about COVID-19. Around 87.47% respondents were aware about high risk age group for COVID-19. 83.54% participants were aware about concept of hand hygiene and 83.37% were well aware of PPE for suspected or confirmed COVID-19 cases.Conclusions: The study participants showed adequate basic knowledge and awareness of COVID-19. There is a strong need to implement periodic educational interventions and training programs on infection control practices and other updates of COVID-19 across all healthcare professions including nursing students.
Effect of barbecue role and Gufoni maneuvers on quality of life in patients with horizontal semicircular canal benign paroxysmal positional vertigo
Authors: Sharma Kumar Gourav , Gupta Ashok Kumar 
Published: June 2020

<p class="abstract"><strong>Background:</strong> Benign paroxysmal positional vertigo (BPPV) is the most common cause in patients with vertigo. Horizontal semi-circular canal BPPV (HSCBPPV) is up to 20% of BPPV. Quality of life (QoL) is significantly impaired by vertigo. Aim of present research was to study the effect and compare barbecue role and Gufoni maneuvers on QoL in patients with HSCBPPV.</p><p class="abstract"><strong>Methods:</strong> 60 individuals with unilateral HSCBPPV were selected. 2 groups barbecue role and Gufoni were formed and 30 individuals were selected in each group randomly. Vestibular activities and participation (VAP) and positional test were administered before and after barbecue role and Gufoni maneuvers to fulfill the aim. </p><p class="abstract"><strong>Results:</strong> VAP scale results revealed significant difference between pre and post treatment score in both groups, suggestive of positive effect on quality of life in patients with HSCBPPV. Improvements in VAP score between both groups were compared and significant difference was observed. Positional test post treatment revealed that 83.33% and 70% patients improved in barbecue role and Gufoni respectively.</p><p class="abstract"><strong>Conclusions:</strong> Barbecue role found to be better than Gufoni in treatment of unilateral HSCBPPV.</p>
HUBUNGAN SMARTPHONE ADDICTION DAN SELF-EFFICACY DENGAN PRESTASI AKADEMIK PADA REMAJA
Authors: Agesti Linda Pradani , Fitryasari Rizki , Armini NK Alit , Yusuf Ah 
Published: June 2020

ABSTRAKPendahuluan: Remaja memiliki ketertarikan yang lebih besar terhadap penggunaan smartphone, hal ini membuat remaja lebih rentan mengalami smartphone addiction. Prestasi akademik di Indonesia masih tergolong rendah hal ini dipengaruhi oleh beberapa faktor yaitu faktor internal contohnya self-efficacy dan faktor eksternal adalah penggunaan smartphone. Tujuan penelitian ini menganalisis hubungan smartphone addiction dan self-efficacy dengan prestasi akademik berdasarkan teori Bandura.Metode: Jumlah sampel adalah 219 siswa dengan menggunakan cluster sampling. Variabel independen adalah smartphone addiction dan self-efficacy. Variabel dependen adalah prestasi akademik. Data dikumpulkan menggunaakan kuesioner dan analisis dengan uji Spearman α < 0,05.Hasil: Smartphone addiction dapat menurunkan self-efficacy (p = 0,009) arah korelasi negatif (r = -0,177). Smartphone addiction juga dapat menurunkan prestasi akademik (p=0,046) arah korelasi negatif (r = -0,135). Self-efficacy tidak memiliki hubungan dengan prestasi akademik (p = 0,262).Kesimpulan: Smartphone addiction dapat membuat remaja mengalami resah apabila tidak menggunakan smartphone, sedangkan self-efficacy dapat dipengaruhi oleh perilaku cemas dan resah. Perawat perlu melakukan pendidikan kesehatan terhadap orangtua maupun siswa terkait kecanduan smartphone dan hubungannya dengan self-efficacy dan prestasi akademik siswa.ABSTRACTIntroduction: Adolescents have a greater interest in smartphone use, this makes teens more vulnerable to experiencing smartphone addiction. Academic achievement in Indonesia is still relatively low, this is influenced by several factors, internal factor like self-efficacy and the external factor includes are smartphone use. The purpose of this study was to analyze the relationship between smartphone addiction and self-efficacy with academic achievement based on Bandura's theory.Method: The number of samples was 219 students by using cluster sampling. The independent variable is smartphone addiction and self-efficacy. The dependent variable is academic achievement. Data were collected using questionnaires and analysis with the Spearman test α <0.05.Result: Smartphone addiction can reduce self-efficacy (p = 0,009) direction of correlation negative (r = -0,177). Smartphone addiction can also reduce academic achievement (p = 0.046) direction of correlation negative (r = -0.135). Self-efficacy has no relationship with academic achievement (p = 0.262).Conclusion: Smartphone addiction can make teenagers experience restlessness when not using a smartphone, while self-efficacy can be influenced by anxious and restless behavior. Nurses need to do health education for parents and students related to smartphone addiction and its relationship with student self-efficacy and academic achievement.