bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA-935 mediates the regulatory effect of lncRNA KCNQ1OT1 on tumor progression of breast cancer
Authors: Zhang Chunjie , Gong Cuixue , Li Jianzhao , Tang Jiaying 
Published: April 2020

Abstract
Background The biological function of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have received increasing attention in the pathogenesis of various malignancies. This study aimed to evaluate the functional role and clinical significance of the KCNQ1OT1/miR-935 axis in breast cancer (BCa) progression. Methods Expression of KCNQ1OT1 and miR-935 was estimated using quantitative real-time PCR (qRT-PCR). The interaction between KCNQ1OT1 and miR-935 was confirmed by luciferase reporter assay. BCa cell proliferation, migration and invasion were evaluated using CCK-8 and Transwell assays. The clinical significance of the KCNQ1OT1/miR-935 axis in BCa diagnosis was examined by ROC analysis. Results The expression of KCNQ1OT1 was significantly elevated, but the miR-935 expression was decreased in BCa cells (all P < 0.01). KCNQ1OT1 could directly bind to miR-935, leading to the decreased miR-935 expression in BCa cells (P < 0.001). The overexpression of miR-935 could inhibit BCa cell proliferation, migration and invasion, and remarkably reversed the regulatory effect of KCNQ1OT1 on BCa cell biological processes (all P < 0.05). Serum KCNQ1OT1 levels were negatively correlated with miR-935 levels in BCa patients. The aberrant expression of KCNQ1OT1 and miR-935 had relatively high diagnostic accuracy for the screening of BCa patients. Conclusion In conclusion, miR-935 expression is downregulated in BCa cells, which can be inhibited by KCNQ1OT1 and mediates the promoting effect of KCNQ1OT1 on BCa tumor progression in vivo. Serum reduced expression of miR-935 may serve as a diagnostic biomarker of BCa, and the KCNQ1OT1/miR-935 axis provides potential therapeutic targets for BCa treatment.
A Case Study on the Impact of Building Envelope on Energy Efficiency in High-Rise Residential Buildings
Authors: AYDIN Dinçer , MIHLAYANLAR Esma 
Published: April 2020

Abstract
The building envelope, the most important element in the energy consumption of a building, gains more importance due to the large amount of the surface area of building’s façade in high-rise buildings. The energy consumption of these buildings is increasing depending on their high transparency ratio as a result of decrease in the thermal resistance of the façade. The aim of this study is to show the importance of building envelope design in energy efficiency of high-rise residential buildings and to analyze the effect of the building envelope design on energy consumption. Turkey’s highest residential building from 2010 to 2017 was selected for the case building. DesignBuilder program with the EnergyPlus simulation engine was used for energy analysis of the building. The energy consumption results were compared with the other study data in the literature. As a consequence of the simulation conducted according to the existing façade of the building, 25% of the energy is used for heating and 14% for cooling in total energy consumption. It has been found that the building envelope designed with double-layered air corridor can offer the maximum level of residential comfort to the occupants. This study shows that the building façade with air corridor also reduces energy consumption by 30% compared to the same sized buildings.
Application of Potassium Ferrate(VI) in the Treatment of Selected Water and Wastewater Pollutants – Short Review
Authors: KLIŚ Simona , BARBUSIŃSKI Krzysztof , THOMAS Maciej , MOCHNACKA Anna 
Published: April 2020

Abstract
The paper presents the application of potassium ferrate(VI) (K2FeO4 ) for the removal of selected pollutants from water and wastewater. The research results on the degradation of endocrine disrupting compounds (EDCs), decomposition of surfactants (SPCs), personal care products (PCPs), pharmaceuticals and their metabolites have been reviewed. Due to K2FeO4 strong oxidizing and coagulating properties, high stability, non–toxic by–products and non–selectivity it is sometimes called “environmentally friendly oxidant”. Due to this reasons K2FeO4 can be a multi–purpose water and wastewater treatment chemical and an alternative to advanced oxidation processes (AOPs).
A Review on Reliability Modeling of Manufacturing Systems Considering the Production Quality and Equipment Reliability
Authors: Li Kewu , Yang Jun , Huang Shuo 
Published: April 2020

Background:
Nowadays, the manufacturing industry is much more fiercely competitive
and global than ever before. For sustainable increases in market share and profitability, manufacturers
are aiming to improve the quality of products and maintain the reliability of manufacturing systems.

Objective:
Therefore, to simultaneously optimize the quality and reliability for manufacturing systems
has become an important research topic in recent years.

Methods:
This study presents an overview of the methods for modeling manufacturing systems,
especially considering the system reliability and the product quality. And then, we review the optimization
methods for manufacturing system maintenance and production strategy.

Conclusion:
Finally, optimization methods and some challenges are summarized for future studies.
PENGARUH CITRA MEREK DAN KUALITAS PRODUK PADA KEPUASAN KONSUMEN DIMODERASI OLEH LOYALITAS (STUDY KASUS PADA LIPSTCIK WARDAH)
Authors: Maharani Oktavia Retno , Wijayanto Heri , Abrianto Tegoeh Hari 
Published: April 2020

Industri kosmetik di Indonesia mengalami perkembangan pesat, maka dari itu perusahaan berlomba-lomba untuk meningkatkan citra merek, dengan adanya citra merek yang bagus konsumen akan memberikan nilai lebih pada barang maupun jasa. Perusahaan dapat memberikan apa yang dituntut oleh konsumen seperti citra merek yang baik dan kualitas produk yang tinggi. Kualitas produk sangat mempengaruhi keberhasilan suatu usaha bisnis. Memuaskan konsumen adalah salah satu dari tujuan perusahan, karena jika konsumen tidak puas mereka akan membelanjakan uang mereka di tempat lain. Loyalitas konsumen juga menjadi salah satu faktor penting bagi suatu perusahaan untuk bisa bertahan dalam persaingan. Populasi dalam penelitian ini adalah konsumen Wardah di Kabupaten Ponorogo. Metode pengambilan sampel yang digunakan adalah metode probality sampling. Sampel dari penelitian ini adalah seluruh warga Kabupaten Ponorogo yang berjumlah 100 orang. Metode pengambilan data menggunakan kuesioner atau angket. Uji hipotesis menggunakn uji t. hasil penelitian menunjukkan: 1 Citra Merek lipstick Wardah berpengaruh pada Kepuasan Konsumen. 2 Kualitas Produk lipstick Wardah berpengaruh pada Kepuasan Konsumen. 3 Loyalitas memperlemah pengaruh antara Citra Merek lipstick Wardah terhadap Kepuasan Konsumen. 4 Loyalitas memperlemah pengaruh antara Kualitas Produk lipstick Wardah terhadap Kepuasan Konsumen. Kata Kunci: Citra Merek, Kualitas Produk, Kepuasan Konsumen, Loyalitas.
¿Libertad y/o planificacion? Releyendo a Karl Mannheim en su cincuentenario
Authors: Tirado Rozúa Juan Ramón 
Published: April 2020

RESUMENEl presente artículo trata de poner de manifiesto con motivo del cincuentenario de la muerte de K. Mannheim la actualdiad de su pensamiento del período anglosajón. Se analiza cómo los procesos históricos fruto del desarrollo desproporcionado de las capacidades humanas -moral e instrumental- han abocado en la sociedad masa. También se trata de poner de manifiesto el nuevo sentido de la libertad y la planificación en las sociedades altamente desarrolladas, así como las nuevas posibilidades de democratización que se abren en su seno, tomando como marco de referencia una "democracia militante" cuyo fundamento es la convicción básica de que el proceso democrático no es un mero procedimiento formal.PALABRAS CLAVEMANNHEIM-LIBERTAD-PLANIFICACIONABSTRACTOn the ocassion of the fiftieth anniversary of the death of K. Mannheim, this paper tries to highlight the presnet day validity of his ideas of the last period. i analyze how historic processed caused by disproportionate development of human capacities- both moral and instrumental- have led to a "mass society". I also try to point out the new sense that the concepts of freedom and planning acquire in highly developed societies and also the new posibilities of democratization that emerge in the heart of these, taking as a point of reference a militant democracy" whose foundation is the basic conviction that the democratic process is not a mere formal procedure. KEYWORDSMANNHEIM-FREEDOM-PLANNING
Structure, Adhesion Strength and Corrosion Resistance of Vacuum Arc Multi-Period NbN/Cu Coatings
Authors: Postelnyk Hanna Oleksandrivna , Sobol O.V. , Chocholaty O. , Zelenskaya G.I. 
Published: April 2020

The influence of deposition modes on the phase-structural state, corrosion resistance, and adhesive strength of vacuum-arc multi-period NbN/Cu coatings is studied. It was found that in thin layers (about 8 nm, in a constant rotation mode), regardless of the change in the pressure of the nitrogen atmosphere, a metastable δ - NbN phase forms (cubic crystal lattice of the NaCl type). At a layer thickness of ~ 40 nm or more, a phase composition changes from the metastable δ - NbN to the equilibrium ε - NbN phase with a hexagonal crystal lattice. In the presence of the ε - NbN phase in the niobium nitride layers, the highest adhesive strength is achieved with a value of LС5 = 96.5 N. Corrosion resistance tests have shown that for all the studied samples the corrosion process has mainly an anodic reaction. The highest corrosion resistance was shown by coatings obtained at a pressure of 7·10-4 Torr, with the smallest bias potential of -50 V and the smallest layer thickness; with a thickness of such a coating of about 10 microns, its service life in the environment of the formation of chloride ions is about a year.
BACKGROUND OF THE TACTICAL DECISIONS IN CRIMINALISTS
Authors: Bululukov O. 
Published: April 2020

The main factors are considered, the appearance and existence of which is the information basis for the emergence of tactical decisions in criminalists. It is Noted that these issues in the forensic literature are considered fragmentarily.
Purpose. The purpose of this article is to identify and disclose the factors that influenced the occurrence of tactical decisions in criminalists.
When considering the history of tactical decisions in criminalists, analysis and synthesis methods were used.
The article focuses on the clarification of information sources (factors) that contributed to the emergence of a New concept in criminalists and criminalists tactics. It is Noted that these factors, in relation to the emergence of the concept of tactical decision in criminalists, are of a general and private Nature. These factors are divided into two groups that are associated: 1) with the emergence and development of decision theory; 2) with the emergence and development of criminalists tactics and its means. Interest in the study of decision-making problems was caused by the development of society, the increase in industrial production and the emergence of large enterprises. The Need to perform complex tasks contributed to the scientific search for ways to solve them. When considering the first group of factors, attention is focused on works related to the study of probability theory and mathematical statistics, as well as game theory. Particular attention is paid to the work of Y. Kozeletsky, “Psychological Theory of Decision Making”. The consideration of the second group of factors related to the development of criminalists tactics and its means was carried out by analyzing literary sources from the beginning of the 19th century. Particular attention is paid to the works of Y. I. Barshev and an analysis of their contents is made, regarding the tactics of investigative actions. The conclusions of the article focus on the fact that the development of criminalists tactics is carried out by developing New tools and improving existing ones. The article concludes about the decisive role of decision theory and criminalists tactics in the formation of the concept of tactical decision.
AUTOMATION OF RESEARCH AREA RECOGNITION UNDER WEAK- CONTRAST BORDERS ON A PICTURE OF TRANSPARENT OBJECTS
Authors: Rombovsky M. , Radchenko R. 
Published: April 2020

Recently, due to the active development of computer technologies, in the field of science dealing with visual objects, there are problems of creating systems for automatic image recognition. This class of problems does not have a universal way of solving and this leads to the fact that, depending on the needs of a particular branch of science and engineering, the developers of such systems are forced to solve problems of a private nature.
The purpose of this work is to create a software product by the authors that would allow automatic recognition of the study area of objects having a weakly expressed boundary between the separation of object and background to further determine the values of the optical characteristics of transparent objects, as common features in identification trace evidence analysis the whole by parts.
One of the main problems of detecting the boundaries of the separation of objects in an image is the poor contrast of the transition region between adjacent areas of the divided space, which leads to the need for image processing to segment and correct the contrast. To develop an effective way to limit the recognition area and identify the boundaries of the studied object under the condition of low contrast between the light background and the space occupied by a transparent medium, which differs from the background in optical properties, there is a need to analyze existing image enhancement algorithms and their further practical implementation using mathematical software products of numerical analysis.
Thus, the paper reviews modern algorithms for image recognition methods and algorithms for changing image quality by segmentation and contrast correction. The proposed algorithms are implemented in a computer program developed by the authors of the Sumy Research Institute of the Ministry of Internal Affairs of Ukraine on the basis of the mathematical software MATLAB, which allows to carry out automatic comparative analysis of the studied samples on the basis of their digital images. The questions posed to the authors for further development of this topic are outlined.
FEATURES RESEARCH EXPERTISE IN CASES CONCERNING THE DETERMINATION OF THE AMOUNT OF THE ACTUAL EXPENDITURES OF THE PENSION FUND FOR THE PAYMENT AND DELIVERY OF OLD-AGE PENSIONS ASSIGNED ON PREFERENTIAL BASIS
Authors: Savchenko I. 
Published: April 2020

This article discusses the theoretical and practical aspects of the features of forensic-economic examinations related to documentary evidence of calculations of the actual costs of the Pension Fund for the payment and delivery of preferential pensions. One of the important issues related to the indicated studies is the validity of calculating the costs of reimbursing pension payments and including in this calculation surcharges, allowances and increases that are intended in accordance with the legislation of Ukraine and are paid from other sources than the funds of the Pension Fund.
The article analyzes the regulatory legal acts of Ukraine, which regulate the procedure for reimbursement by the Pension Fund body of the actual costs of payment and delivery of old-age pensions assigned on preferential terms. The categories that are entitled to the granting of old-age pensions on preferential terms are determined, the differences in the calculation of preferential length of service are indicated. including during the period of work in elected posts, during the passage of military service and study for a specialty that gives the right to a pension. It was clarified which of the costs incurred by the Pension Fund of Ukraine are not refundable and indicated the need to determine the monthly amount of the pension, which is refundable. It is noted that the calculation includes the actual expenses incurred by the territorial bodies of the Pension Fund for which these pensions were assigned.
The theoretical and practical aspects of conducting such forensic examinations presented in the article can be used in expert practice in order to optimize expert research.
Aportes de la Recreación en la Apropiación del Espacio Público
Authors: Cortés Astrid Bibiana Rodríguez 
Published: April 2020

El presente artículo busca visibilizar los aportes que hacen la recreación en la construcción de un espacio público accesible, integrador y placentero, siendo este base estructural de una buena calidad de vida. El uso del espacio público con actividades recreo-deportivas crea lazos físicos y simbólicos entre el espacio y las personas, además de fomentar el encuentro social, la participación ciudadana y el cuidado ambiental. Desde esta perspectiva se analiza la Ciclovía de la ciudad de Bogotá, un espacio público de recreación masivo que ha promovido la integración ciudadana y la convivencia social. Este espacio usa como mediación la actividad física y la recreación para incentivar la ciudadanía activa. Administrada por el Instituto Distrital de Recreación y Deporte, la Ciclovía, además de convertirse en baluarte de la capital colombiana, también ha sido ejemplo de “buenas prácticas”, su modelo se ha replicado en diversos lugares de América. Pese a que se ha logrado señalar los beneficios de los programas masivos de recreación y deporte en la calidad de vida de los bogotanos, la inversión económica en este campo sigue siendo insuficiente. Por tanto, es primordial generar indicadores sociales que sustenten la necesidad de una mayor inversión así como evidenciar aún más los aportes de este campo en la construcción de espacios públicos colectivos que interpelan la propuesta de ciudades atomizadas y ciudadanos atemorizados e individualistas.
Pendampingan Siswa SMP Dan SMA Dalam Memainkan Alat Musik Tradisional Sasando Daun Untuk Melestarikan Alat Musik Tradisional Etnik Nusa Tenggara Timur
Authors: Basri Muntasyir , Jutomo Lewi , Edon Caro David Hadel , Mayners Marline , Awaluddin Sri Prilmayanti 
Published: April 2020

This community service aims to empower junior and senior high school students to improve their knowledge, abilities and skills in playing NTT ethnic traditional musical instruments as an effort to preserve local culture, especially traditional musical instruments. Implementation methods are designed based on community empowerment methods including identification of schools and target participants, preparation of training tools and materials, provision of materials, introduction of sasando daun traditional musical instruments, recognition of tone and sound, training and use of playing sasando daun traditional musical instruments and monitoring and evaluation and sustainability. This activity is carried out on St. Catholic Catholic Middle School students Familia and Kupang Superior Generation Christian High School, each 20 students. The results of the activity showed that as many as 40 participants were able to play the Sasando Daun traditional musical instrument skillfully, skillfully and well. It is expected that with the presence of 40 students the students will be able to direct and motivate other students to play the traditional Sasando Daun musical instrument so as to be able to preserve the NTT ethnic culture, especially maintaining the ability to play this instrument. For the continuation of the activities of all these students will be included in the appearance of the traditional Sasando Daun musical instrument play in various events in Kupang and outside Kupang and formed the Sasando Traditional Music Art Unit.
ANALISIS PERSEPSI KUALITAS, KEPUASAN PELANGGAN DAN REPUTASI PERUSAHAAN TERHADAP MINAT ULANG MENGGUNAKAN JASA TRANSPORTASI
Authors: Wolok Tineke 
Published: April 2020

The concept of customer satisfaction is important for marketing managers where customer satisfaction can encourage repeat purchases. Consumer satisfaction is an important asset for the company because it can be used as an indicator of the company's quality and income in the future. The population of this study was 137 passengers a month. Determination of the number of samples in this study using a statistical approach, the sample size in the study amounted to 58 respondents. the results of the analysis and discussion above, the conclusions that can be drawn in this study are as follows: (1) Simultaneous problems between the influence of perceived quality, customer satisfaction and company reputation simultaneously have a significant effect on re-interest in using Gorontalo Tour & Travel transportation services. The partial problem between the influence of perceived quality, customer satisfaction and company reputation has a significant effect on re-interest in using Gorontalo Tour & Travel transportation services.
Keywords: Quality Perception, Customer Perception, Company Problems, Retention using Transportation
When Does the Onset of Multiple Stellar Populations in Star Clusters Occur? III. No Evidence of Significant Chemical Variations in Main-sequence Stars of NGC 419
Authors: Li Chengyuan , Wang Yue , Tang Baitian , Milone Antonino P. , Yang Yujiao , Ji Xin 
Published: April 2020

Abstract
Recent studies have revealed that the onset age for the presence of multiple stellar populations (MPs) in star clusters seems to correspond to the disappearance of the extended main-sequence turnoff in young clusters, a pattern associated with stellar rotations. A speculative suggestion is that MPs might be caused by the magnetic brake, a stellar evolutionary effect linked to rotation. In this work, we use the young massive cluster NGC 419 as a testbed. We examined if its magnetically baked MS stars would exhibit MPs. Using the deep ultraviolet and visible images observed through the Hubble Space Telescope, combined with a specific color index that is sensitive to the nitrogen (N) abundance, we examined if its late G- and K-type MS stars are affected by N variation. Our analysis reports that the morphology of its GK-type MS is most likely a simple stellar population, and only a negligible probability, which indicates a N variation up to 0.4 dex is present. We therefore conclude that there is no significant N variation among its GK-type MS stars. The absence of a significant chemical variation among the late-type MS stars indicates that MPs might not be a specific pattern of magnetically braked stars.