bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of new generation triptans – frovatriptan and almotriptan – on hemodynamic parameters in intact male and female rats
Authors: Saracheva Kremena , Hrischev Petar , Vasileva Liliya , Topolov Mariyan , Nikolova Julia , Getova Damianka 
Published: January 2020

Abstract
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. We used a non-invasive “tail-cuff” method to measure the arterial blood pressure. Female and male Wistar rats were treated separately with high and low dosages of frovatriptan and almotriptan. Male and female rats showed reduction in all hemodynamic parameters, but only male rats showed an increase in the heart rate. In general, we could say that both almotriptan and frovatriptan potentiate cardiovascular safety.
Cavitation Erosion Resistance Influence of Material Properties
Authors: Zakrzewska D. E. , Krella A. K. 
Published: January 2020

Abstract
The cavitation erosion is the phenomena that causes degradation of fluid flow machinery components due to repetitive implosion of cavitation bubbles adjacent to the solid surface. Cavitation erosion is a complex phenomenon, which includes not only hydrodynamic factors of liquid, but also properties of erodible material e.g. microstructure, hardness or Young modulus. In order to reduce the negative impact of erosion on machine components, there are many methods to increase cavitation erosion resistance. The paper discusses the correlations between structural and mechanical properties and the resistance to cavitation erosion (CER) of pure materials, their alloys and coatings. Methods to increase CER have also been described - using heat / thermo-chemical treatment and application of coatings by various methods.
Chronopharmacology of high blood pressure—a critical review of clinical evidence
Authors: Potucek P. , Klimas J. 
Published: January 2020

Abstract
Physiological functions of cardiovascular system (CVS) are exhibiting circadian patterns regulated by complex system of endogenous factors. Preserving this rhythmicity is important for its normal function, whereas disturbing the synchronization with natural day–night cycle can increase the risk of cardiovascular damage. Cardiovascular pathophysiology also follows cyclic variation; time susceptibility and period with maximum risk associated with elevated blood pressure (BP) can be predicted. Given this rhythmic nature, significant changes in efficacy between morning and evening administration of the drug may occur; appropriate timing of pharmacological intervention in therapy of hypertension may affect the efficacy of the treatment.
Molecular docking study of L-Asparaginase I from Vibrio campbellii in the treatment of acute lymphoblastic leukemia (ALL)
Authors: Mohideen Abdul Khader Sultan 
Published: January 2020

Abstract
The potential use of asparaginases has gained tremendous significance in the treatment of acute lymphoblastic leukemia (ALL). Earlier studies suggest L-asparaginases (L-ASP) extracted from Escherichia coli and Erwinia aroideae regulates L-asparagine (L-Asn) from the circulating blood. Prolonged exposure to these enzymes may lead to hypersensitivity reactions. So, it is important to find novel asparaginases with anti-cancer properties. The three-dimensional structure of L-ASP I from Vibrio campbellii was determined by homology modeling using EasyModeller v.4.0. The structure was validated with quality indexing tools and was deposited in Protein Model DataBase. Molecular docking was performed between L-ASP I and ligand substrate L-Asn to study enzyme-substrate interactions. Qualitative and quantitative analysis of L-ASP I enzyme was found to be reliable and stable with a significant protein quality factor (LG score: 7.129). The enzyme is a dimer, belongs to α/β class of proteins. The active sites comprises of N-glycosylation site and a catalytic triad (T14-S117-D92). The binding energy of the docked complex was calculated to be -7.45 kcal/mol. The amino acid T14 identified as a primary nucleophile essential for catalytic reaction. The enzyme L-ASP I of V. campbellii provides a detailed view of structure and functional aspects with ligand substrate L-Asn. This in silico investigation has explicitly demonstrated for the first time that cytosolic L-ASP Type I of V. campbellii to have a catalytic triad which was attributed only to periplasmic L-ASP Type II. Thus, L-ASP I can serve as anti-leukemic agent in the treatment, management and control of ALL.
Foreign Trade Liberalisation and Economic Growth: The Case of the Republic of Srpska
Authors: Popović Goran , Erić Ognjen , Popović Srđa 
Published: January 2020

Abstract
This paper assesses the impact of trade liberalisation on the economic growth of the Republic of Srpska (RS). The aim of the research is to prove the hypothesis that trade liberalisation and export orientation positively impact on GDP growth. RS has characteristically small and open economies. The degree and character of the connections between the observed variables was determined by means of regression analysis. Regression analysis indicates that there is a positive connection between the total trade and GDP growth. Further, there is a marked positive correlation between export and GDP, that is, export growth contributes to GDP growth. Foreign trade deficit stands in a negative correlation with GDP. Lastly, regression analysis points to the connection between the Republic of Srpska economic growth and openness of its economy. However, uncontrolled opening and exposure to foreign competitiveness can also bring about problems which in certain circumstances lead to long-term macroeconomic instability.
The In-Out Spatial Relation as Conceptualized and Verbalized by Danish Directional Adverbs and their Equivalents in Polish
Authors: Kacprzak Aleksander 
Published: January 2020

Abstract
The present paper aims to investigate and compare the conceptualization and verbalization of the in-out relation in Danish and Polish. The introductory paragraphs focus on the differences in the distribution of content in Polish and Danish employing Leonard Talmy’s typological classification of languages into verb-framed and satellite-framed, and provide information about Danish Directional Adverbs which are believed to be the key to understanding spatial relations in Danish. The analysis in the following paragraph reveals similarities and differences in the perception of the in-out relation through image schemas such as CONTAINER and CENTER-PERIPHERY. The analysis of the CENTER-PERIPHERY image schema in Danish reveals that there is often a presupposed reference point in situations where the directional adverb does not refer to the in-out relation denoted by the prepositional phrase, which leads to a description of the general structure of this image schema in the last part of the article.
The Early Miocene Bats (Chiroptera, Mammalia) from the Karstic Sites of Erkertshofen and Petersbuch 2 (Southern Germany)
Authors: Rosina Valentina V. , Rummel Michael 
Published: January 2020

Abstract
Fossil bats are described from the karstic deposits of the Erkertshofen 1, Erkertshofen 2 and Petersbuch 2 sites in eastern Bavaria, southern Germany (MN 4). Fossils are discussed with regard to taxonomic, stratigraphic and palaeoecologic significance. The rich fossil material represents at least 12 different bat species belonging to Megadermatidae, Rhinolophidae and Vespertilionidae. The syntopic appearance of four different rhinolophids is demonstrated for the first time for the Neogene bat assemblages of Europe. The remains of Rhinolophidae and Vespertilionidae are the most numerous, of which the proportion of typically early Miocene species Rhinolophus aff. lemanensis, R. dehmi, Hanakia agadjaniani and Miostrellus cf. petersbuchensis are significant. However, there are also remains of R. cf. delphinensis, M. cf. noctuloides, Plecotus cf. atavus and H. aff. antiquus, which are characteristic of the younger middle Miocene faunas of Central Europe. Analysis of the composition of the bat fauna has allowed biostratigraphic correlation of the studied faunas to be estimated at a number of other early Miocene localities in Europe.
The role of calprotectin in rheumatoid arthritis
Authors: Wang Qin , Chen Weiqian , Lin Jin 
Published: January 2020

Abstract
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by inflammatory cell infiltration, high levels of cytokines, and erosion of cartilage and bone in joints. Calprotectin (CLP), as a recently described member of S100 family proteins, is a heterodimeric complex of S100A8 and S100A9. Currently, plenty of studies have indicated significantly increased serum and synovial fluid levels of CLP in patients with RA. It was reported that CLP was related to cell differentiation, migration, apoptosis, and production of pro-inflammatory factors in RA. In addition, there are the positive relationships between serum, synovial CLP and traditional acute phase reactants, disease activity, ultrasound and radiographic progression of joints, and treatment response of RA. In this review, we mainly discuss the role of CLP in the pathogenesis of RA as well as its potential to estimate clinical disease progression of RA patients.
Research progress in acute hypertensive renal injury by “in vivo cryotechnique”
Authors: Sun Da , Wang Jiaojiao , Yao Li , Li Zilong , Ohno Shinichi 
Published: January 2020

Abstract
Arterial hypertension has a large prevalence in the general population and as a major hypertensive target organ, the involvement of kidney is usually hard to avoid and gradually develops into chronic kidney disease (CKD). Acute hypertension is defined as a blood pressure greater than 180/120, also known as hypertensive emergency (HE). In acute severe hypertension, the pathophysiology damage to the kidney tends to worsen on the basis of chronic damage, and accounts for more significant mortality. However, the mechanisms of renal injury induced by acute hypertension remain unclear. This review summarizes the clinical and histopathological features of hypertensive renal injury by using “in vivo cyrotechnique” and focusses on the interplay of distinct systemic signaling pathways, which drive glomerular podocyte injury. A thorough understanding of the cellular and molecular mechanisms of kidney damage and repair in hypertension will provide significant insight into the development of new research methods and therapeutic strategies for global CKD progression.
Pharmacokinetics and pharmacodynamics of anti-infective agents during continuous veno-venous hemofiltration in critically ill patients: Lessons learned from an ancillary study of the IVOIRE trial
Authors: Breilh Dominique , Honore Patrick M. , De Bels David , Roberts Jason A. , Gordien Jean Baptiste , Fleureau Catherine , Dewitte Antoine , Coquin Julien , Rozé Hadrien , Perez Paul , Attou Rachid , Redant Sebastien , Kugener Luc , Saux Marie-Claude , Spapen Herbert D. , Ouattara Alexandre , Joannes-Boyau Olivier 
Published: January 2020

Abstract

Background
Hemofiltration rate, changes in blood and ultrafiltration flow, and discrepancies between the prescribed and administered doses strongly influence pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents during continuous veno-venous hemofiltration (CVVH) in critically ill patients.

Methods
Ancillary data were from the prospective multicenter IVOIRE (hIgh VOlume in Intensive caRE) study. High volume (HV, 70 mL/kg/h) was at random compared with standard volume (SV, 35 mL/kg/h) CVVH in septic shock patients with acute kidney injury (AKI). PK/PD parameters for all antimicrobial agents used in each patient were studied during five days.

Results
Antimicrobial treatment met efficacy targets for both percentage of time above the minimal inhibitory concentration and inhibitory quotient. A significant correlation was observed between the ultrafiltration flow and total systemic clearance (Spearman test: P < 0.005) and between CVVH clearance and drug elimination half-life (Spearman test: P < 0.005). All agents were easily filtered. Mean sieving coefficient ranged from 38.7% to 96.7%. Mean elimination half-life of all agents was significantly shorter during HV-CVVH (from 1.29 to 28.54 h) than during SV-CVVH (from 1.51 to 33.85 h) (P < 0.05).

Conclusions
This study confirms that CVVH influences the PK/PD behavior of most antimicrobial agents. Antimicrobial elimination was directly correlated with convection rate. Current antimicrobial dose recommendations will expose patients to underdosing and increase the risk for treatment failure and development of resistance. Dose recommendations are proposed for some major antibiotic and antifungal treatments in patients receiving at least 25 mL/kg/h CVVH.
Walled-off peripancreatic fluid collections in Asian population: Paradigm shift from surgical and percutaneous to endoscopic drainage
Authors: Theerasuwipakorn Nonthikorn , Tasneem Abbas Ali , Kongkam Pradermchai , Angsuwatcharakon Phontep , Ridtitid Wiriyaporn , Navicharern Patpong , Kitisin Krit , Wangrattanapranee Peerapol , Rerknimitr Rungsun , Kullavanijaya Pinit 
Published: January 2020

Abstract

Background and Objectives
Drainage of symptomatic walled-off peripancreatic fluid collections (WPFCs) can be achieved by endoscopic, percutaneous, and surgical techniques. The aim of this study was to determine the current trends in management of WPFCs and the outcome of such modalities in Asian population.

Methods
In this retrospective analysis, all patients diagnosed with pancreatitis from 2013 to 2016 in King Chulalongkorn Memorial Hospital, Bangkok, Thailand, were analyzed. Relevant clinical data of all patients with peripancreatic fluid collections (PFCs) was reviewed. Clinical success was defined as improvement in symptoms after drainage.

Results
Of the total 636 patients with pancreatitis, 72 (11.3%) had WPFCs, of which 55 (8.6%) and 17 (2.7%) had pancreatic pseudocyst (PP) and walled-off necrosis (WON), respectively. The commonest etiologies of WPFCs were alcohol (38.9%) and biliary stone (29.2%). Post-procedure and pancreatic tumor related pancreatitis was found in 8.3% and 6.9% patients, respectively. PP was more common in chronic (27.8%) than acute (5.5%) pancreatitis. Of the 72 patients with WPFCs, 31 (43.1%) had local complications. Supportive, endoscopic, percutaneous, and surgical drainage were employed in 58.3%, 27.8%, 8.3%, and 5.6% with success rates being 100%, 100%, 50%, and 100%, respectively. Complications that developed after percutaneous drainage included bleeding at procedure site (n = 1), infection of PFC (n = 1), and pancreatic duct leakage (n = 1).

Conclusion
Over the past few years, endoscopic drainage has become the most common route of drainage of WPFCs followed by percutaneous and surgical routes. The success rate of endoscopic route is better than percutaneous and comparable to surgical modality.
An analysis of flooding coverage using remote sensing within the context of risk assessment
Authors: Solovey Tatiana 
Published: January 2020

Abstract
Results of research of the identification of flooding as a result of groundwater table fluctuations on the example of the valley of the River Vistula, with the use of multi-spectral Sentinel-2 images from the years 2017–2018 are presented. An analysis of indexes of water use, calculated on the basis of green, red and shortwave infrared (SWIR) bands, for extraction of water objects and flooded areas was carried out. Based on the analyses conducted, a mapping method was developed, using three water indexes (MNDWI Modified Normalised Difference Water Index, NDTI Normalised Difference Index and NDPI Normalised Difference Pond Index). Results show that the 10 metre false colour composite RNDTIGNDPIBMNDWI obtained significantly improved submerged extractions more than did individual water indexes. Moreover, the 10-m-images of MNDWI and NDPI, obtained by the sharpening High Pass Filter (HPF), may represent more detailed spatial information on floods than the 20-m-MNDWI and NDPI, obtained from original images.
Possibilities of safe yield increase in the Wydrzany well field (Uznam Island, Poland) by surface water from a drainage system
Authors: Hoc Ryszard , Sadurski Andrzej , Wiśniowski Zenon 
Published: January 2020

Abstract
In parallel with intensified development of the Polish part of Uznam Island, there is an increase in the demand for drinking water in this area. This island ranks among areas with low water resources, which at the present time are allocated. In order to create the prospect of increased groundwater resources, a concept has been developed that allows for the recovery of part of the freshwater from drainage systems which discharge into the waters of Szczecin Lagoon or the River Świna. The present article discusses the secondary use of water from drainage systems for supply of the Wydrzany resource area. The notion of using water from the White Bridge pumping station was considered the most promising. The catchment area of the polder is 880 ha, 280 ha of which are located on Polish territory. The White Bridge pumping station transfers water from the polder, which it leads to the Peat Channel which, in turn, drains water gravitationally into Szczecin Lagoon. Here, results of simulations aimed at the use of drainage water to improve upon groundwater resources in the “Wydrzany” intake are discussed. On the basis of these simulations of artificial water supply to the intake, an increase of available resources by up to 50 per cent may be expected.
In-Situ and Laboratory Investigation on Leaching and Effects of Early Curing of Shotcrete
Authors: Sjölander Andreas , Ansell Anders 
Published: January 2020

Abstract
During the construction of a rock tunnel in Stockholm, several sections with leaching shotcrete (sprayed concrete) were found one year after the spraying was completed. An investigation was therefore conducted, and its results are presented in this paper. The amount of leaching after such a short time indicated that a one-sided water pressure existed in combination with a permeable shotcrete. The reason for the water pressure was likely a partly unsuccessful grouting that created sections with leaking water. The permeable shotcrete could be a combined result of insufficient curing and the use of accelerators, and the effect of in-situ curing was therefore investigated. A total of six slabs were sprayed and cured under different conditions in the tunnel. Test results according to standards indicated that curing has no significant effect on the development of mechanical strength or water penetration through the shotcrete. However, this is believed to be a result of the test method rather than the non-existing effect of curing. Lastly, some modifications to the test standard were proposed for future studies of in-situ curing.
Effect on Radon Exhalation Rate Due to Cracks in Concrete
Authors: Döse Magnus , Silfwerbrand Johan 
Published: January 2020

Abstract
The second largest cause of lung cancer in the World is related to radon (222Rn) and its progenies in our environment. Building materials, such as concrete, contribute to the production of radon gas through the natural decay of 238U from its constituents. The Swedish Cement and Concrete Research Institute (CBI), part of RISE (Research Institute of Sweden AB), has examined the effects of cracks in concrete on two different concrete recipes where an Ordinary Portland Cement, OPC-CEM-I concrete (REF) and an OPC concrete including a hydrophobic additive (ADD) were addressed. Two concrete prisms from each concrete recipe were examined. The radon exhalation rate was measured in the pristine state and after concrete cracks had been induced into the concrete prisms. Measurements were performed with an ATMOS 33 ionizing pulsation chamber. The results indicate a strong influence of cracks on the radon exhalation rate. An increase in radon exhalation rate was calculated for every test prism. The increase in radon exhalation rate varied between 80 and 260 %. The crack apertures may play a significant role on the exhalation rate. The concrete prisms with the largest apertures (ADD) also generated the highest radon exhalation rates. The results imply that there could be a substantial variation in the exhalation rate, due to numerous factors, but nonetheless, the results should, raise the awareness of the impact cracks in concrete structures, may have on the final exhalation rate of radon. The exhalation rate of the recipe with an additive (ADD) also showed a lower exhalation rate than for the reference recipe (REF), when compared in a pristine state. This was in part expected. However, the effect of induced cracks and its aperture, seemingly trumps the effect that an additive may play on the radon exhalation rate, when cracks are induced.
The hypothesis is in part verified in view of the results of the prism for the ordinary Portland recipe (REF-prisms), were an increase of approximately 100 % would be expected due to the total surface increase. The results also indicate this. The major increase in the radon exhalation rate of the ordinary Portland recipe including an additive, implies however other factors, such as minor internal cracks, that may substantially contribute to the final exhalation rate.
Emil Cioran – with Marin Sorescu
Authors: Stuparu Ada 
Published: January 2020

Abstract
Marin Sorescu”s trips to Paris meant, each time, meeting Emil Cioran. The spiritual closeness between the two so different personalities develops over the years, as prooved by the numerous notes in the diaries of the Romanian poet. Despite the political restrictions of the regime, Marin Sorescu promotes Emil Cioran’s work in Romania, in the magazines of the time and in volumes. About his appreciation is written also in the correspondence between the two of them, we publish here some unique texts kept in the archive of Sorescu family.
Hermeneutical Perspectives In Matei Vişniec’s Poetical Discourse
Authors: Popa Savu 
Published: January 2020

Abstract
In Matei Vişniec’s literature, there is a gap between poetry and theater, which consists primarily on the ability of creating, in both species mentioned, areas or dramatic situations by using a parabolic or symbolic dimension of images. Matei Vişniec wrote poems that follow closely to the plays he wrote, which both his poems and plays including the same ingredients: the presence of characters, narrative situations, symbols, irony, and life seen as a complex spectacle. By using fantasy, the poet tends to transfer reality in a symbolic gap between the surface image and the depth image. Therefore, we will discuss two crucial aspects that involve the semnification of the theatrical dimension of look, by analysing a couple of important example of poems from his books and by consulting some critical point of views. In his poetry, we will find an interesting perspective of the so called the overturned look, which involves the relation of approaching and distancing between the surface image and the depth image. The first meaning of this dimension is to reveal a daily spectacle of life by presenting his apparently ordinary situations and people. In this case, the concept of mask will be discussed and its relation between essence and appearance. The second meaning involves the aspects that underline the loneliness and anxiety in the modern times.