bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erianthridin Induces Non-small Cell Lung Cancer Cell Apoptosis through the Suppression of Extracellular Signal-regulated Kinase Activity
Authors: Boonjing Sirima , Pothongsrisit Sutthaorn , Wattanathamsan Onsurang , Sritularak Boonchoo , Pongrakhananon Varisa 
Published: November 2020

AbstractDue to the high mortality of lung cancer, natural derivative compounds have been promoted as versatile sources for anticancer drug discovery. Erianthridin, a phenanthrene compound isolated from Dendrobium formosum, exhibits intriguing apoptosis-inducing effects in non-small cell lung cancer cells. Apoptotic nuclei staining assays showed that apoptotic cells with DNA fragmentation and apoptotic bodies were apparent, and an increase in annexin V-FITC-positive cells were found in cells treated with erianthridin. The apoptosis protein markers for cleaved caspase-3 and cleaved poly-ADP-ribose polymerase were significantly upregulated in response to erianthridin. A mechanistic investigation revealed that erianthridin was able to attenuate extracellular signal-regulated kinase activity and thereby mediate apoptosis through the modulation of Bcl-2 family protein levels. U0126, an extracellular signal-regulated kinase inhibitor, augmented the apoptosis-inducing effect of erianthridin; in contrast, overexpression of exogenous extracellular signal-regulated kinase substantially abrogated erianthridin activity. Furthermore, an in vitro 3D tumorigenesis assay showed that erianthridin was able to potentially suppress lung cancer cell proliferation. This study is the first to report a promising cytotoxic effect of erianthridin, which provides preclinical evidence for further research and development of this compound.
Plasmacytoma Masquerading as Meningioma
Authors: Erdem Münibe Büşra , Çakmak Pınar , Akyürek Nalan , Dogulu Fikret 
Published: November 2020

AbstractSolitary bone plasmacytoma is a rare disease in the skull. We present a 70-year-old patient who presented with a skull deformity due to the left parietooccipital tumor. Neurological examination found no deficit. The systemic scanning revealed no additional lesion. The surgery was planned, and the tumor was removed totally with the marginal bone around it. Histopathological examination confirmed solitary bone plasmacytoma. The patient is being followed-up without recurrence or progression to multiple myeloma. As the calvarial solitary bone plasmacytomas can be easily misdiagnosed preoperatively, the detailed examination of the CT features may be helpful for the planning and course of the surgery.
Clinical and Genetic Varieties of Gaucher Disease in Iraqi Children
Authors: Ibraheem Mohammad Fadhil , Ahmed Shaymaa Jamal 
Published: November 2020

AbstractGaucher disease (GD), which is due to a deficiency in the lysosomal enzyme β-glucocerebrosidase, is a rare genetic disorder. It is characterized by a wide variety of clinical manifestations and severity of symptoms, making it difficult to manage. A cross-sectional hospital-based genetic study was undertaken with 32 pediatric patients. We recruited 21 males and 11 females diagnosed with GD, with a male-to-female ratio of 1.91:1. The mean age of the study population was 8.79 ± 4.37 years with an age range from 8 months to 17 years. We included patients on clinical evaluation from 2011 to 2019. An enzyme assay test was used to measure β-glucosidase enzyme activity in leukocytes and the GBA gene study was performed by polymerase chain reaction technique. We found GD type 1 in 27 (84.37%) participants, GD type 3 in five (15.63%) participants, while none classified as GD type 2. The dominant mutation in GD 1 was N370S in 81.5%, of which two-thirds were homozygous. The second common mutation in this type of disease (L444P) was present in nine cases (40.9%), two of whom were homozygous (9.9%). Meanwhile, R463C was present in six cases (27.27%), of whom one was homozygous. In GD 3, the dominant mutation was L444P as seen in 80% of the patients followed by N370S and R463C in 20%. This study shows that the most common mutant allele in this study was N370S, followed by L444P. Further large-scale studies with more advanced designs are recommended to explore the sequences of GBA genes.
On the connection between bound and scattering states of finite square-well potentials: a unified approach
Authors: Morrison Ian , Ekey Robert , Biaggio Ivan , Mitchell Brandon 
Published: November 2020

Abstract
We discuss a general description of the solutions to the 1D time-independent Schrödinger equation that does not a priori distinguish between scattering states and bound states and emphasizes and reinforces their relationship and connection to each other. This manuscript also introduces the concept of transfer matrices, which it presents as a logical extension of the traditional approach to evaluating 1D potentials. Using the transfer matrix method and a finite step approximation allows for a simple and straight-forward numerical solution of arbitrary 1D potentials. It also separates the process of solving the Schrödinger equation from selecting physically relevant solutions, which is a critical skill in quantum mechanics and is at the core of physics problems in general.
Sliding down a rough curved hill
Authors: Ivchenko Vladimir 
Published: November 2020

Abstract
In this paper, we analyse the process of a particle sliding down an arbitrary curved hill in the presence of friction. We show that in this case, the kinetic friction force turns out to be effectively dependent on the speed. We find that the final speed for each concave (convex) profile should be less (greater) than that for the corresponding inclined plane. In the limit of extremely small final speed or profiles of the hill close to linear, the final speed does not depend on the shape of the trajectory even in the presence of kinetic friction. As an illustrative example, we perform the calculation of the final speed for a concave hill in the form of a quarter circle. We also derive the shape of the curved hill profile for which a body can slide down at a constant speed.
Kinetics of metastable N2(A3Σu

+
, v) molecules in high-pressure nonequilibrium plasmas
Authors: Jans E R , Raskar S , Yang X , Adamovich I V 
Published: November 2020

Abstract
Absolute, time-resolved populations of N2(A3Σu
+, v = 0–5) vibrational levels in high-pressure ns pulse discharge plasmas are measured by Tunable Diode Laser Absorption Spectroscopy (TDLAS). The diffuse plasma is generated by a repetitively pulsed, double dielectric barrier, ns discharge across a 10 mm gap in a plane-to-plane geometry, at pressures of up to 400 Torr. The results of TDLAS measurements in nitrogen and in H2–N2, O2–N2, and NO–N2 plasmas are compared with kinetic modeling predictions, identifying the mechanisms of N2(A3Σu
+) generation and decay during the discharge pulses and in the afterglow. Comparison with the modeling predictions indicates that electron impact dissociation of N2 from the ground electronic state significantly underpredicts the yield of N atoms. The present data suggest that N2 dissociation in the plasma also occurs during the energy pooling process in collisions of two N2(A3Σu
+) molecules. The results also show that high-pressure, high repetition rate, volume-scalable ns pulse discharges can be used for efficient generation of atomic species for plasma chemical and plasma catalysis syntheses. In an NO–N2 mixture, it is shown that the N2(A3Σu
+) decay is controlled by the rapid energy transfer to NO, resulting in its electronic excitation and UV emission (NO γ bands). The diagnostics used in the present work can be used for the accurate characterization of both high-pressure, low-temperature gas discharge plasmas and high-temperature nonequilibrium flows generated in pulsed facilities such as shock tubes and expansion tunnels.
Magnetorheological damper with multi-grooves on piston for damping force enhancement
Authors: Liu Gaoyu , Gao Fei , Liao Wei-Hsin 
Published: November 2020

Abstract
Due to low power consumption and fast response, magnetorheological (MR) dampers are widely used in various engineering applications. To enhance the performances, efforts have been made to increase the field dependent force with the same power consumption. However, the fluid viscous force is also increased significantly, which is undesirable in practical use. To tackle this problem, the focus of this paper is to design, simulate, and test an MR damper with multi-grooves (small multiple annular flow gaps) on piston for performance enhancement. First, the detailed design of the proposed MR damper is provided. Then, a coupled field model to describe the characteristics of MR fluid in different regions of MR damper is derived. Based on this model, multiphysics simulations are performed using COMSOL Multiphysics. Parametric analysis of the number and width of multi-grooves is also conducted. Experimental results of the two MR dampers without and with multi-grooves are given and compared with the simulation results. The advantages of MR damper with multi-grooves over the one without multi-grooves and the accuracy of the coupled field model are validated by experiments and simulations. This is the first time that the advantages of MR damper with multi-grooves are validated by experiments. Compared with MR damper without multi-grooves, MR damper with multi-grooves has larger damping force and controllable force range, as well as less increment of fluid viscous force while keeping the same increase of field dependent force. The performance of MR damper with multi-grooves could be further improved by increasing the number and decreasing the width of multi-grooves.
A new design of magnetic circuits in magnetorheological dampers for simple structure subjected to small stroke and low damping force
Authors: Lee Tae-Hoon , Kang Byung-Hyuk , Kim Gi-Woo , Choi Seung-Bok 
Published: November 2020

Abstract
A magnetorheological (MR) damper is popularly applied for vibration control owing to its fast response and the easy controllability of the field-dependent damping force. However, most of the existing MR dampers developed so far possess design complexity and a high manufacturing cost due to complicated coil structures. To resolve these drawbacks of the existing MR dampers, a novel magnetic circuit positioned separately from the piston head of MR damper with a simple structure is proposed in this work. As a first step, a design configuration using the operating principle of the magnetic circuit is demonstrated, and subsequently, the magnetic analysis of MR damper is carried out through an analytical approach and the finite element method. In the magnetic analysis, the magnetic flux density is numerically calculated at various piston locations with different applied currents. After determining the principal design parameters of the proposed MR damper, experimental validation to demonstrate the concept of the new magnetic circuit is performed. The effect of the piston stroke length on the damping force is evaluated as a function of the current. In addition, it is discussed that the proposed MR damper can provide much higher control range of the damping force than conventional types of MR dampers in a low level of damping force.
Voltage response of three ionic polymer pressure sensors based on ion migration at different ambient humidities
Authors: Li Shiping , Liu Hu , Zhu Zicai , Sun Xiaofei , Tang Zhenhua , Guo Yan , Hu Qiao , Zhang Yong 
Published: November 2020

Abstract
Besides bending sensor, ionic polymer materials can work as pressure sensor based on ion migration and show more potential in engineering application. To explore a better ionic polymer material for pressure sensor, three typical ionic polymer materials, Nafion, poly(vinylidene fluoride)/ionic liquid (IL/PVDF) composite, thermoplastic polyurethane/ionic liquid (IL/TPU) composite, were selected to comparatively investigate the sensing properties under an applied pressure. Ionic polymer pressure sensors with circular truncated cone structure were developed by casting method. Their voltage responses were evaluated by a self-made test platform under a series of step force. The voltage sensitivity and the stability were obtained by performing the tests at different ambient humidity levels. The sensitivity of Nafion sensor was influenced by the ambient humidity heavily, which increased from 8.97 mV N−1 (28.17 mV MPa−1) to 31.11 mV N−1 (97.69 mV MPa−1) as the relative humidity (RH) increasing from 30% RH to 90% RH. In comparison, the voltage responses of IL/TPU sensor and IL/PVDF sensor were rarely influenced by the humidity because of the stability of IL, but strongly related to the content of IL. As the IL content increasing from 30 wt.% to 50 wt.%, the sensitivity of IL/TPU sensor increased from 5.65 mV N−1 (17.74 mV MPa−1) to 16.55 mV N−1 (51.97 mV MPa−1), that of IL/PVDF sensor increased from 14.12 mV N−1 (44.33 mV MPa−1) to 32.23 mV N−1 (101.20 mV MPa−1) monotonously. The underlying mechanisms were revealed based on water exchange in air and ion transport theory qualitatively. IL/PVDF sensor with 50 wt.% IL content shows the best sensing performance in air and is promising for practical application.
Magnetorheology of exotic magnetic mesostructures generated under triaxial unsteady magnetic fields
Authors: Terkel Matthew , de Vicente Juan 
Published: November 2020

Abstract
Traditionally, the rheological properties of magnetorheological (MR) fluids are investigated under uniaxial steady (DC) fields. These basic fields promote the aggregation of magnetically attractive particles into chain-like structures aligned in the field driven direction. In this manuscript we show how triaxial unsteady fields can generate a variety of exotic mesostructures and influence the rheological response of the MR fluids. We bridge understanding the rheological response to each unique particle structure through videomicroscopy, x-ray microtomography and rheometry tests. Small-amplitude oscillatory shear and steady shear tests lay out an unmistakable argument for MR enhancement with both elevated storage modulus and yield stress responses following a sequence of steady uniaxial and unsteady fields. We demonstrate that structures assembled through time-averaged particle interactions or typical dipole–dipole magnetostatic interactions, especially when columnar structures are strengthened through lateral chain coalescence, can boost rheological response.
Terahertz tunable optical dual-functional slow light reflector based on gold-graphene metamaterials
Authors: Xu Hui , Chen Zhiquan , He Zhihui , Nie Guozheng , Li Deqiong 
Published: November 2020

Abstract
Tunable terahertz optical dual-functional slow light reflector based on gold-graphene metamaterials has been designed and the proposed structure can achieve a good optical reflection effect and slow light effect. The tunable function can be dynamically controlled by applying a voltage to the gold and it can achieve a good effect for selecting reflection band. In more detail, the gold in this device can enable us to dynamically tune the Fermi level of graphene, thus this device can achieve a good tunable effect. Compared with other structures, the graphene monolayer in this structure is simpler and forms a complete band distribution, laying a solid foundation for the subsequent implementation of the device. Through the derivation and analysis of the optical equivalent-cavity coupled mode theory, the theoretical fitting transmission and reflection of this device can be obtained, and they are in good agreement with the numerical results. Furthermore, the slow light effect of this device has been analyzed and it is found that this device has a better slow light performance. This investigation is expected to provide a theoretical basis for the realization of tunable slow light reflectors.
Irreversibility, heat and information flows induced by non-reciprocal interactions
Authors: Loos Sarah A M , Klapp Sabine H L 
Published: November 2020

Abstract
We study the thermodynamic properties induced by non-reciprocal interactions between stochastic degrees of freedom in time- and space-continuous systems. We show that, under fairly general conditions, non-reciprocal coupling alone implies a steady energy flow through the system, i.e., non-equilibrium. Projecting out the non-reciprocally coupled degrees of freedom renders non-Markovian, one-variable Langevin descriptions with complex types of memory, for which we find a generalized second law involving information flow. We demonstrate that non-reciprocal linear interactions can be used to engineer non-monotonic memory, which is typical for, e.g., time-delayed feedback control, and is automatically accompanied with a nonzero information flow through the system. Furthermore, already a single non-reciprocally coupled degree of freedom can extract energy from a single heat bath (at isothermal conditions), and can thus be viewed as a minimal version of a time-continuous, autonomous ‘Maxwell demon’. We also show that for appropriate parameter settings, the non-reciprocal system has characteristic features of active matter, such as a positive energy input on the level of the fluctuating trajectories without global particle transport.
Dynamic focusing of laser driven positron jets by self-generated fields
Authors: Kim J , Link A , Canning D , Fitzsimmons P , Fooks J A , Kerr S , Ma T , Manuel M J-E , Mariscal D , Wallace R , Williams G J , Willingale L , Beg F N , Chen H 
Published: November 2020

Abstract
Focusing effect of laser-driven positron jets by self-generated target sheath fields has been observed for the first time experimentally and the results are supported by the computational studies. In the experiment, OMEGA EP short-pulse (0.7 ps, 500 J) irradiates mm-size gold targets with a concave back surface and reference flat-surface targets. Both targets exhibited positrons with quasi-monoenergetic energy peaks while targets with concave curvature also showed increased number of positrons at the detector. The data is consistent with hybrid-PIC simulations confirming that the time-varying electric fields driven by electrons escaping from the target significantly change the trajectories of positrons. These simulations show a small radius of curvature on the rear side increases the relative focusing effect and the positrons to electrons ratio in the escaping plasma. For the smallest radius of curvature, positron jets that are up to 10 times denser can be achieved.
Spectroscopic properties of Δ baryons
Authors: Menapara Chandni , Shah Zalak , Kumar Rai Ajay 
Published: November 2020

Abstract
The resonance state of the

baryon, which exists in four isospin (

) states, has been studied using the hypercentral constituent quark model (hCQM) with a simple linear potential with added first order correction. The calculated data ranges for 1S-5S, 1P-5P, 1D-4D and 1F-2F are given, with possible spin-parity assignments for all the states. The magnetic moments have also been obtained for all four configurations. The

decay channel width has been calculated for a few states. The linear nature of the data has been verified through Regge trajectories.
Diffuseness effect and radial basis function network for optimizing α decay calculations *
Authors: Ma Na-Na , Bao Xiao-Jun , Zhang Hong-Fei 
Published: November 2020

Abstract
A radial basis function network (RBFN) approach is adopted for the first time to optimize the calculation of

decay half-life in the generalized liquid drop model (GLDM), while concurrently incorporating the surface diffuseness effect. The calculations presented herein agree closely with the experimental half-lives for 68 superheavy nuclei (SHN), achieving a remarkable reduction of 40% in the root-mean-square (rms) deviations of half-lives. Furthermore, using the RBFN method, the half-lives for four SHN isotopes, 252-288Rf, 272-310Fl, 286-316119, and 292-318120, are predicted using the improved GLDM with the diffuseness correction and the decay energies from WS4 and FRDM as inputs. Therefore, we conclude that the diffuseness effect should be embodied in the proximity energy. Moreover, increased application of neural network methods in nuclear reaction studies is encouraged.
Commissioning of the CALIFA Barrel Calorimeter of the R3B Experiment at FAIR
Authors: Cabanelas P , Alvarez-Pol H , Boillos J M , Casarejos E , Cederkall J , Cortina D , Feijoo M , Galaviz D , Galiana E , Gernhäuser R , Golubev P , González D , Hartig A-L , Heinz A , Johansson H , Klenze P , Knyazev A , Kröll T , Nacher E , Park J , Perea A , Ponnath L , Rhee H-B , Rodríguez-Sánchez J L , Suerder C , Tengblad O , Teubig P 
Published: November 2020

Abstract
CALIFA is the high efficiency and energy resolution calorimeter for the R3B experiment at FAIR, intended for detecting high energy charged particles and γ-rays in inverse kinematics direct reactions. It surrounds the reaction target in a segmented configuration of Barrel and Forward End-Cap pieces. The CALIFA Barrel consists of 1952 detection units made of CsI(Tl) long-shaped scintillator crystals, and it is being commissioned during the Phase0 experiments at FAIR. The first setup for the CALIFA Barrel commissioning is presented here. Results of detector performance with γ-rays are obtained, and show that the system fulfills the design requirements.
Mesons at finite chemical potential and the Silver-Blaze property of QCD
Authors: Gunkel Pascal J , Fischer Christian S , Isserstedt Philipp 
Published: November 2020

Abstract
We summarize our results for light (pseudo-)scalar mesons at finite chemical potential and vanishing temperature. We extract the meson bound state wave functions, masses, and decay constants up to the first-order phase transition from the homogeneous Bethe-Salpeter equation and confirm the validity of the Silver-Blaze property. For this purpose, we solve a coupled set of truncated Dyson-Schwinger equations for the quark and gluon propagators of QCD in Landau gauge.
Charmonium Decays at BESIII
Authors: Küßner Meike 
Published: November 2020

Abstract
Although the charmonium spectrum seems to be well understood and was a role model on how theory and experiment worked hand in hand, the charmonium spectrum still rises questions. For states as hc
, χXcJ and ηC(2S), the majority of decay channels is still unknown. Since the charmonium states occur in the transition region of perturbative and non-perturbative QCD, theoretical predictions suffer from large uncertainties. Experimental challenges arise from limited statistics due to the production processes of non vector states. The BESIII collaboration studies extensively the charmonium spectrum and the decay behavior of charmonium states to shed light on the various questions. In this article recent results on charmonium decays studied by BESIII will be presented.
Exploration of the phase diagram and the thermodynamic properties of QCD at finite temperature and chemical potential with the PNJL effective model
Authors: Motta Mario , Alberico Wanda Maria , Beraudo Andrea , Costa Pedro , Stiele Rainer 
Published: November 2020

Abstract
The QCD transition from a hadronic to a quark-gluon plasma phase is a cross-over at vanishing/small baryo-chemical potential, while at higher chemical potentials it is argued that it becomes of first order, ending with a critical end-point. The present goal is the determination of the critical line and, possibly, the recognition of the critical endpoint. For this purpose, the effective model (Nambu-Jona-Lasinio model with Polyakov Loop) with 2+1 flavours is used. In Mean Field Approximation it is possible to obtain all thermodynamic quantities (pressure, entropy, energy and quark density) and their fluctuations, in particular, the generalized quark-number susceptibilities. We use the net baryon-number fluctuations and net-strangeness fluctuations to identify the critical line and the order of the phase transition in the chemical potential-temperature plane.