bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Lethal Intoxication by Ingestion of 50 Castor Beans: Serial Measurement of Ricinine in Blood, Plasma and Urine
Authors: Lefever Stefanie , Geerts Inge , Vermeulen Edith , Vermeersch Pieter , De Rydt Frederic , Dobbels Laurens , Gillis Marc , Croes Kathleen 
Published: September 2020

Abstract
A 30-year-old woman presented to the emergency department 2 days after ingestion of 50 castor beans. Her symptoms on admission were vomiting, diarrhea, abdominal cramps, agitation and anxiety. Initial laboratory tests showed a slightly elevated C-reactive protein and mild liver and kidney dysfunction. The patient was transferred to the medium care unit of our hospital where she was observed for possible organ failure. During the next days, the kidney function improved and liver function started to recover. Four days after admission, the patient was transferred to the psychiatric ward. Urine, serum, plasma and whole-blood samples were analyzed for ricinine using a quantitative LC–MS-MS method. Initial values on admission (serum and urine) were very high in comparison with previously reported cases. Based on these values, the patient was monitored closely in the following days. The patient made a full recovery, and during the course of hospitalization, concentrations of ricinine in plasma/serum, blood and urine gradually declined. The presence of ricinine in a patient’s blood or plasma is a proof of castor bean and, hence, ricin exposure. However, based on this case and previously reported cases in literature, we can conclude that no clear correlation can be established between ricinine blood, plasma or urine levels and the severity of the intoxication. Clinicians should be aware of the potential danger of a ricin intoxication, and patients should be monitored closely for several days due to the unpredictable outcome of the intoxication.
Optimal Retirement Policies with Present-Biased Agents
Authors: Yu Pei Cheng 
Published: September 2020

Abstract
This paper incorporates quasi–hyperbolic discounting into a Mirrlees taxation model to study the design of retirement policies for present-biased agents. I show that the government can improve the screening of productivity by exploiting time inconsistency. This is done by providing commitment to sophisticated agents and taking advantage of the incorrect beliefs of naïve agents. This can be achieved even if the degrees of present bias and sophistication are private information. I also demonstrate how the government can implement the optimal mechanism using retirement savings accounts and social security benefits.
Test Case Prioritization—ANT Algorithm With Faults Severity
Authors: Vescan Andreea , Pintea Camelia-M , Pop Petrică C 
Published: September 2020

AbstractRegression testing is applied whenever a code changes, ensuring that the modifications fixed the fault and no other faults are introduced. Due to a large number of test cases to be run, test case prioritization is one of the strategies that allows to run the test cases with the highest fault rate first. The aim of the paper is to present an optimized test case prioritization method inspired by ant colony optimization, test case prioritization–ANT. The criteria used by the optimization algorithm are the number of faults not covered yet by the selected test cases and the sum of severity of the faults. The cost, i.e. time execution, for test cases is considered in the computation of the pheromone deposited on the graph’s edges. The average percentage of fault detected metric, as best selection criterion, is used to uncover maximum faults with the highest severity, and reducing the regression testing time. Several experiments are considered, detailed and discussed, comparing various algorithm parameter’s alternatives. A benchmark project is also used to validate the proposed approach. The obtained results are encouraging, being a cornerstone for new perspectives to be considered.
Temperature as a constraint on the timing and duration of African elephant foraging trips
Authors: Rozen-Rechels David , Valls-Fox Hugo , Mabika Cheryl Tinashe , Chamaillé-Jammes Simon 
Published: September 2020

Abstract
In arid and semiarid environments, water is a key resource that is limited in availability. During the dry season, perennial water sources such as water pans often are far apart and shape the daily movement routines of large herbivores. In hot environments, endotherms face a lethal risk of overheating that can be buffered by evaporative cooling. Behavioral adjustments are an alternative way to reduce thermal constraints on the organism. The trade-off between foraging and reaching water pans has been studied widely in arid environments; however, few studies have looked into how ambient temperature shapes individual trips between two visits to water. In this study, we tracked during the dry season the movement of eight GPS-collared African elephants (Loxodonta africana) cows from different herds in Hwange National Park, Zimbabwe. This species, the largest extant terrestrial animal, is particularly sensitive to heat due to its body size and the absence of sweat glands. We show that most foraging trips depart from water at nightfall, lowering the average temperature experienced during walking. This pattern is conserved across isolated elephant populations in African savannas. We also observed that higher temperatures at the beginning of the trip lead to shorter trips. We conclude that elephants adjust the timing of foraging trips to reduce the thermal constraints, arguing that further considerations of the thermal landscape of endotherms are important to understand their ecology.
Primary tracheal schwannoma resected in a Turner syndrome patient: a case report
Authors: Chávez-Fernández D A , Zúñiga-Garza E , López-Saucedo R A 
Published: September 2020

Abstract
We report a case of primary tracheal schwannoma in a 31-year-old woman. She had a previous history of follicular thyroid carcinoma treated surgically and Turner syndrome. In a follow-up computed tomography scan, we found a partially obstructing intraluminal tracheal tumor, which was confirmed by bronchoscopy. The patient was treated by surgical resection and primary tracheal anastomosis. The tumor was 14 mm in diameter, with an intact capsule. Histologic analysis revealed a Schwann cell origin tumor.
The sound of silence: Breathing analysis for finding traces of trauma and depression in oral history archives
Authors: Salah Almila Akdag , Salah Albert Ali , Kaya Heysem , Doyran Metehan , Kavcar Evrim 
Published: September 2020

AbstractMany people experience a traumatic event during their lifetime. In some extraordinary situations, such as natural disasters, war, massacres, terrorism, or mass migration, the traumatic event is shared by a community and the effects go beyond those directly affected. Today, thanks to recorded interviews and testimonials, many archives and collections exist that are open to researchers of trauma studies, holocaust studies, and historians, among others. These archives act as vital testimonials for oral history, politics, and human rights. As such, they are usually either transcribed or meticulously indexed. In this work, we propose to look at the nonverbal signals emitted by victims of various traumatic events when they describe the trauma and we seek to render these for novel representations without taking into account the explicit verbal content. Our preliminary paralinguistic analysis on a manually annotated collection of testimonials from different archives, as well as on a corpus prepared for depression and post-traumatic stress disorder detection indicates a tentative connection between breathing and emotional states of speakers, which opens up new possibilities of exploring oral history archives.
Sub-Chandrasekhar-mass detonations are in tension with the observed t0−MNi56 relation of type Ia supernovae
Authors: Kushnir Doron , Wygoda Nahliel , Sharon Amir 
Published: September 2020

ABSTRACT
Type Ia supernovae (SNe Ia) are likely the thermonuclear explosions of carbon–oxygen (CO) white-dwarf (WD) stars, but their progenitor systems remain elusive. Recent studies have suggested that a propagating detonation within a thin helium shell surrounding a sub-Chandrasekhar mass CO core can subsequently trigger a detonation within the core (the double-detonation model, DDM). The outcome of this explosion is similar to a central ignition of a sub-Chandrasekhar mass CO WD (SCD). While SCD is consistent with some observational properties of SNe Ia, several computational challenges prohibit a robust comparison to the observations. We focus on the observed t0−MNi56 relation, where t0 (the γ-rays’ escape time from the ejecta) is positively correlated with MNi56 (the synthesized 56Ni mass). We apply our recently developed numerical scheme to calculate SCD and show that the calculated t0−MNi56 relation, which does not require radiation transfer calculations, converges to an accuracy of a few per cent. We find a clear tension between our calculations and the observed t0−MNi56 relation. SCD predicts an anticorrelation between t0 and MNi56, with $t_0\approx 30\, \textrm{d}$ for luminous ($M_\text{Ni56}\gtrsim 0.5\, \mathrm{ M}_{\odot }$) SNe Ia, while the observed t0 is in the range of $35\!-\!45\, \textrm{d}$. We show that this tension is larger than the uncertainty of the results, and that it exists in all previous studies of the problem. Our results hint that more complicated models are required, but we argue that DDM is unlikely to resolve the tension with the observations.
A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination
Authors: Garg Angad , Shuman Stewart , Schwer Beate 
Published: September 2020

AbstractFission yeast phosphate homeostasis genes are repressed in phosphate-rich medium by transcription of upstream lncRNAs that interferes with activation of the flanking mRNA promoters. lncRNA control of PHO gene expression is influenced by the Thr4 phospho-site in the RNA polymerase II CTD and the 3′ processing/termination factors CPF and Rhn1, mutations of which result in hyper-repression of the PHO regulon. Here, we performed a forward genetic screen for mutations that de-repress Pho1 acid phosphatase expression in CTD-T4A cells. Sequencing of 18 independent STF (Suppressor of Threonine Four) isolates revealed, in every case, a mutation in the C-terminal pyrophosphatase domain of Asp1, a bifunctional inositol pyrophosphate (IPP) kinase/pyrophosphatase that interconverts 5-IP7 and 1,5-IP8. Focused characterization of two STF strains identified 51 coding genes coordinately upregulated vis-à-vis the parental T4A strain, including all three PHO regulon genes (pho1, pho84, tgp1). Whereas these STF alleles—asp1-386(Stop) and asp1-493(Stop)—were lethal in a wild-type CTD background, they were viable in combination with mutations in CPF and Rhn1, in which context Pho1 was also de-repressed. Our findings implicate Asp1 pyrophosphatase in constraining 1,5-IP8 or 1-IP7 synthesis by Asp1 kinase, without which 1-IPPs can accumulate to toxic levels that elicit precocious termination by CPF/Rhn1.
Congregations Serving Homeless Populations: Examining Predictive Factors and Policy Implications
Authors: Fisher Catherine C , Ortiz Larry , Alemi Qais , Malika Nipher M 
Published: September 2020

AbstractIn this study, authors analyzed data from the 2012 National Congregations Study (NCS) to explore what factors are predictive of a congregation’s engagement in programs serving people experiencing homelessness. Using a cross-sectional sample of 1,328 congregations derived from the third wave of the NCS, authors applied multivariate logistic regression to identify congregational characteristics associated with programming for homeless adults. Approximately one-fourth of all congregations in our sample reported some type of homeless programming. The authors’ final model indicates that 10 variables predict greater likelihood of congregations having programs serving the homeless, which include factors such as larger annual spending and lower percentage low-income congregants; recent formation of a nonprofit entity; collaboration with another organization; certain religious traditions; and the presence of other sponsored programs such as (a) services targeting a specific gender, (b) services helping sexual assault and domestic violence victims, and (c) services for older adults. Given the ongoing U.S. homelessness crisis, this study may help housing authorities and local continuums of care identify congregations for potential partnership to help achieve the Housing First policy priorities and meet specific homeless subpopulation needs.
Effects of Violence on Trauma among Immigrant Women from Central America
Authors: Vila Arlette , Pomeroy Elizabeth C 
Published: September 2020

Abstract
The purpose of the study was to explore the effects of violence on trauma among forced-immigrant women from the northern triangle of Central America (NTCA) resulting from direct and indirect violence in their country of origin and during the migratory journey through Mexico. In trauma theory the concept of compounding stressors is an important framework for understanding aspects of human development, especially among low-socioeconomic-status and oppressed populations. Authors hypothesized that violence would have an impact on trauma and conducted interviews with 108 women ages 18 to 65 from the NTCA who traveled by land across Mexico before entering the United States. A survey instrument captured demographic information and types of violence experienced in the home country and during the migratory journey. A standardized screening tool was used to measure trauma symptoms. A hierarchical regression model for trauma was entered in the following order: (a) demographics and (b) violence. Violence was found to be a significant predictor for trauma. Findings suggest that having experienced violence in the country of origin and through the migratory journey had a powerful role in predicting trauma symptoms among immigrant women from the NTCA.
A Comparison of Casting Versus Splinting for Nonoperative Treatment of Pediatric Phalangeal Neck Fractures
Authors: Liao Janice C.Y. , Huan Sarah K.W. , Tan Ruth E.S. , Lim Jin Xi , Chong Alphonsus K.S. , Das De Soumen 
Published: September 2020

Background:
Phalangeal neck fractures account for 13% of pediatric finger fractures. Al Qattan type I (undisplaced) fractures are treated nonoperatively. There is increasing evidence that Type 2 (displaced) fractures achieve remarkable fracture remodeling with nonoperative treatment and patients frequently make a full functional recovery. The options available for nonoperative management of these fractures are either a plaster cast or a removable splint. We hypothesized that there would be no significant difference in radiologic outcome in pediatric phalangeal neck fractures (Types I and II) treated with splint or cast immobilization.

Methods:
This is a retrospective study of patients aged 18 and below with phalangeal neck fractures treated nonoperatively from 2008 to 2017. Radiographs were compared at <1 week and >3 weeks after injury. Translation and angulation in coronal and sagittal planes were measured and compared using Student t tests. Baseline variables were compared using χ2 or Fisher exact tests.

Results:
There were 47 patients with phalangeal neck fractures treated nonoperatively during the study period. There were 9 type I and 38 type II fractures. The mean age was 10 years with 40 males and 7 females. Fractures occurred in 33 dominant and 14 nondominant hands and involved 29 proximal and 18 middle phalanges. Nineteen children were treated in casts and 28 with removable splints. The mean duration of follow-up was similar between the 2 groups. The most affected phalanx was the proximal phalanx of the small finger and the most common fracture pattern was type IIA. There was no significant difference in clinical and radiologic outcomes between children who were treated in casts and those treated in removable splints.

Conclusion:
There was no difference in the clinical and radiologic outcomes in pediatric phalangeal neck fractures treated with cast or splint immobilization. Splinting has the added benefits of increased comfort and hygiene and we routinely offer splinting as a viable alternative in the nonoperative treatment of Al Qattan type I and type II phalangeal fractures.

Type of Study/Level of Evidence:
Level III—therapeutic studies.
Intraoperative Neuromonitoring Use Patterns in Degenerative, Nondeformity Cervical Spine Surgery
Authors: Konopka Jeffrey A. , Grabel Zachary J. , Segal Dale N. , Rhee John M. 
Published: September 2020

Study Design:
A cross-sectional survey study.

Objective:
To determine the neuromonitoring (NM) usage patterns among cervical spine surgeons when performing degenerative, nondeformity cervical spine surgery.

Summary of Background Data:
Intraoperative NM is frequently used in spine surgery. Although there is literature to support the use of NM in deformity surgery, its utility in degenerative cervical spine surgery remains unclear.

Materials and Methods:
A survey was distributed to members of the Cervical Spine Research Society to assess practice patterns of NM use during degenerative cervical spine surgery. The survey consisted of 17 multiple choice questions. The first 3 questions focus on practice experience. The remaining 14 questions pertain to NM practice patterns in the setting of radiculopathy and myelopathy.

Results:
Significantly more surgeons routinely (>75% of the time) used NM for myelopathy versus radiculopathy (64% vs. 38%, P<0.001). Private practitioners were overall more likely to use NM than academicians (55% vs. 28%, P=0.007 for radiculopathy; 75% vs. 57%, P=0.09 for myelopathy). No significant difference in NM usage was found comparing neurosurgeons and orthopedic spine surgeons. The most commonly cited primary reasons for NM usage were prevention of positioning/hypotension-related neurological complications, and medicolegal protection.

Conclusions:
Routine NM use during degenerative cervical surgery is significantly more common in myelopathy and is thought to be of more value than in radiculopathy. However, the most common reasons for usage were to provide medicolegal cover and to mitigate neurological complications related to positioning/hypotension, rather than to protect against direct surgical events. These findings contrast the prevailing notion that NM is beneficial in reducing complications related to events occurring in the surgical site when performing spinal deformity correction. We believe that these data provide an important baseline for informing best practice guidelines and further study regarding appropriate NM use for degenerative, nondeformity, cervical spine surgery.
Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019–Induced Vasodilatory Shock: A Retrospective Matched Cohort Study
Authors: Leisman Daniel E. , Mastroianni Fiore , Fisler Grace , Shah Sareen , Hasan Zubair , Narasimhan Mangala , Taylor Matthew D. , Deutschman Clifford S. 
Published: September 2020

Objectives:
To assess the early physiologic response to angiotensin-II treatment in patients with coronavirus disease 2019–induced respiratory failure and distributive shock.

Design:
Retrospective consecutive-sample cohort study.

Setting:
Three medical ICUs in New York during the coronavirus disease 2019 outbreak.

Patients:
All patients were admitted to the ICU with respiratory failure and were receiving norepinephrine for distributive shock.

Interventions:
The treatment groups were patients who received greater than or equal to 1 hour of angiotensin-II treatment. Time-zero was the time of angiotensin-II initiation. Controls were identified using a 2:1 hierarchical process that matched for 1) date and unit of admission; 2) specific organ support modalities; 3) age; 4) chronic lung, cardiovascular, and kidney disease; and 5) sex. Time-zero in the control group was 21 hours post vasopressor initiation, the mean duration of vasopressor therapy prior to angiotensin-II initiation in the treated group.

Measurements and Main Results:
Main outcomes were trajectories of vasopressor requirements (in norepinephrine-equivalent dose) and mean arterial pressure. Additionally assessed trajectories were respiratory (Pao
2/Fio
2, Paco
2), metabolic (pH, creatinine), and coagulation (d-dimer) dysfunction indices after time-zero. We also recorded adverse events and clinical outcomes. Trajectories were analyzed using mixed-effects models for immediate (first 6 hr), early (48 hr), and sustained (7 d) responses. Twenty-nine patients (n = 10 treated, n = 19 control) were identified. Despite matching, angiotensin-II–treated patients had markedly greater vasopressor requirements (mean: 0.489 vs 0.097 µg/kg/min), oxygenation impairment, and acidosis at time-zero. Nonetheless, angiotensin-II treatment was associated with an immediate and sustained reduction in norepinephrine-equivalent dose (6 hr model: β = –0.036 µg/kg/min/hr; 95% CI: –0.054 to –0.018 µg/kg/min/hr, p
interaction=0.0002) (7 d model: β = –0.04 µg/kg/min/d, 95% CI: –0.05 to –0.03 µg/kg/min/d; p
interaction = 0.0002). Compared with controls, angiotensin-II–treated patients had significantly faster improvement in mean arterial pressure, hypercapnia, acidosis, baseline-corrected creatinine, and d-dimer. Three thrombotic events occurred, all in control patients.

Conclusions:
Angiotensin-II treatment for coronavirus disease 2019–induced distributive shock was associated with rapid improvement in multiple physiologic indices. Angiotensin-II in coronavirus disease 2019–induced shock warrants further study.
Complications of Monochorionic Diamniotic Twins: Stepwise Approach for Early Identification, Differential Diagnosis, and Clinical Management
Authors: Micheletti Talita , Eixarch Elisenda , Bennasar Mar , Martinez Josep María , Gratacos Eduard 
Published: September 2020

Abstract
One in three monochorionic twins may develop complications during pregnancy. Monochorionic twins, especially monochorionic diamniotic (MCDA), present specific problems caused by the presence of interfetal placental anastomoses. The first critical step in the management of MCDA twins is identification in the first trimester. Secondly, close follow-up every 2 weeks is mandatory to allow early diagnosis and timely treatment of twin-twin transfusion syndrome. Other potentially severe complications include selective fetal growth restriction, twin anemia polycythemia syndrome or single fetal death. Thirdly, a correct differential diagnosis is critical to establish the best therapy. This may represent a clinical challenge since MCDA twin complications often overlap. A simple diagnostic algorithm may be of great help to establish the right diagnosis and management option. In this review we summarize the main steps for the clinical follow-up, differential diagnosis, and targeted management of MCDA twins complications.
Paraneoplastic Conjunctival Acanthosis Nigricans: A Case Report
Authors: Huang Natalie , Yin Han Y. , Swan Robert 
Published: September 2020

Purpose:
To report a patient who presented with red eye and diffuse palpebral conjunctival thickening and papillary growth bilaterally.

Methods:
A 63-year-old woman with a medical history of stage IV adenocarcinoma of the lung with metastasis to the bone, the lung, and the lymph nodes presented with redness and irritation of both eyes for 3 months. The patient has been treated with topical corticosteroids for 3 weeks with no relief of symptoms.

Results:
Clinical examination and pathology report of conjunctival biopsy confirmed the diagnosis of conjunctival acanthosis nigricans.

Conclusions:
Conjunctival acanthosis nigricans is a rare paraneoplastic condition that resembles papilloma and can present a challenge in diagnosis. When acanthosis nigricans occurs after the diagnosis of malignancy, it can be an indicator of progression of the underlying condition. The diagnosis of conjunctival acanthosis nigricans in a patient with no history of cancer should prompt clinicians for further malignancy workup.