bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative Assessment of Ventriculostomy-Related Hemorrhage: A Volume-Based Classification System to Predict New Neurological Symptoms
Authors: Roa Jorge A , Fakih Rami , Zanaty Mario , Pazour Avery , Howard Matthew A , Hasan David M , Samaniego Edgar A 
Published: October 2020

Abstract

BACKGROUND
Hemorrhage is one of the most feared complications following ventriculostomy placement. Current studies have assessed factors associated with increased risk of ventriculostomy-related hemorrhage (VRH). However, the clinical significance of VRH has not been determined.

OBJECTIVE
To correlate quantitative volumetric measurements of VRH with new neurological symptoms.

METHODS
A retrospective review of our institutional database of ventriculostomy patients during the last decade was performed. Patients’ demographics and procedural details such as indication, number of passes and position of the catheter were recorded. VRH volume was quantified on noncontrast head computed tomography using the Picture Archiving Communication System (Carestream Vue®, Rochester, New York) semi-automated livewire segmentation tool. Patients with new neurological symptoms within 48 h of VRH were considered symptomatic. Several clinical confounders were ruled out. Logistic regression analyses were performed. The best volumetric cut-offs in predicting symptomatic VRH were determined through receiver operating characteristic (ROC) curve analysis.

RESULTS
A total of 3090 patients underwent ventriculostomy procedures and 179 (∼6%) developed VRH. A total of 41 (1.06%) patients with VRH developed new neurological symptoms. Only 12 (0.39%) were attributable to a new VRH. Multivariable logistic regression showed that volume of the hemorrhage (OR 1.17, P = .006) is the only significant predictor of symptomatic VRH. ROC curve analysis demonstrated that VRH volume <1.10 cc has 91.7% sensitivity to rule out symptomatic VRH, whereas a volume >7.59 cc has 95.5% specificity to predict symptomatic VRH.

CONCLUSION
Approximately 6% of patients developed postprocedural VRH, but only 0.4% were symptomatic. VRH volumes <1 cc are extremely unlikely to become symptomatic, whereas volumes >7.5 cc may predict development of new neurological deficits.
Elemental abundances of M dwarfs based on high-resolution near-infrared spectra: Verification by binary systems
Authors: Ishikawa Hiroyuki Tako , Aoki Wako , Kotani Takayuki , Kuzuhara Masayuki , Omiya Masashi , Reiners Ansgar , Zechmeister Mathias 
Published: October 2020

ABSTRACT
M dwarfs are prominent targets of planet search projects, and their chemical composition is crucial to understanding the formation process or interior of orbiting exoplanets. However, measurements of elemental abundances of M dwarfs have been limited due to difficulties in the analysis of their optical spectra. We conducted a detailed chemical analysis of five M dwarfs (Teff ∼ 3200–3800 K), which form binary systems with G/K-type stars, by performing a line-by-line analysis based on high-resolution (R ∼ 80000) near-infrared (960–1710 nm) spectra obtained with CARMENES (Calar Alto high-Resolution search for M dwarfs with Exo-earths with Near-infrared and optical Échelle Spectrographs). We determined the chemical abundances of eight elements (Na, Mg, K, Ca, Ti, Cr, Mn, and Fe), which are in agreement with those of the primary stars within measurement errors (∼0.2 dex). Through the analysis process, we investigated the unique behavior of atomic lines in a cool atmosphere. Most atomic lines are sensitive to changes in the abundance of not only the corresponding elements but also other elements, especially dominant electron donors such as Na and Ca. The Ti i lines show a negative correlation with the overall metallicity at Teff &lt; 3400 K due to the consumption of neutral titanium by the formation of TiO molecules. These findings indicate that to estimate the overall metallicity or the abundance of any element correctly, we need to determine the abundances of other individual elements consistently.
Engineering sensitivity and specificity of AraC-based biosensors responsive to triacetic acid lactone and orsellinic acid
Authors: Wang Zhiqing , Doshi Aarti , Chowdhury Ratul , Wang Yixi , Maranas Costas D , Cirino Patrick C 
Published: October 2020

Abstract
We previously described the design of triacetic acid lactone (TAL) biosensor ‘AraC-TAL1’, based on the AraC regulatory protein. Although useful as a tool to screen for enhanced TAL biosynthesis, this variant shows elevated background (leaky) expression, poor sensitivity and relaxed inducer specificity, including responsiveness to orsellinic acid (OA). More sensitive biosensors specific to either TAL or OA can aid in the study and engineering of polyketide synthases that produce these and similar compounds. In this work, we employed a TetA-based dual-selection to isolate new TAL-responsive AraC variants showing reduced background expression and improved TAL sensitivity. To improve TAL specificity, OA was included as a ‘decoy’ ligand during negative selection, resulting in the isolation of a TAL biosensor that is inhibited by OA. Finally, to engineer OA-specific AraC variants, the iterative protein redesign and optimization computational framework was employed, followed by 2 rounds of directed evolution, resulting in a biosensor with 24-fold improved OA/TAL specificity, relative to AraC-TAL1.
Desire to have children and preferences regarding to pre-pregnancy counselling in women with SLE
Authors: Blomjous Birgit S , Johanna I P de Vries , Zijlstra , Eveline , Cramer , Kyra , Voskuyl , Alexandre E , Bultink and Irene E M 
Published: October 2020

Abstract

Objectives
Pre-pregnancy counselling in women with systemic lupus erythematosus (SLE) is important in order to improve knowledge on the risks of pregnancy and to optimize pregnancy outcomes. Knowledge on the preferences of women with SLE regarding pre-pregnancy counselling have not yet been studied. In a closely monitored cohort of women with SLE we enquired about the present status of their wish to have children, and wish for and experiences with pre-pregnancy counselling.

Methods
A questionnaire developed by physicians in collaboration with two women with SLE was sent to all (n = 177) women participating in the Amsterdam SLE cohort. The questionnaire comprised 32 items, of which 15 focused on the above-mentioned three themes.

Results
A total of 124 women (70%) returned the questionnaire. The median disease duration was 13 years (interquartile range 9–19). Childlessness occurred in 51 women and 31% declared this was due to SLE [conscious decision (21%), stringent medical advice (6%), infertility due to medication (4%)]. Half of the women preferred the first pre-pregnancy counselling immediately after the SLE diagnosis (53%), together with their partner (69%). Information given by healthcare providers (81%) was preferred over information provided via brochures (35%) or the internet (26%). Pre-pregnancy face-to-face counselling from a rheumatologist and/or gynaecologist separately was preferred in 54%.

Conclusion
One-third of women attributed their childlessness to SLE-related reasons. Pre-pregnancy counselling was preferred shortly after the onset of the disease in a non-multidisciplinary setting. The results of this study underline the importance of timely pre-conceptional counselling by healthcare providers on fertility, risks and pregnancy outcomes in women with SLE.
EEG response to game-craving according to personal preference for games
Authors: Ha Jihyeon , Park Wanjoo , Park Sang In , Im Chang-Hwan , Kim Laehyun 
Published: October 2020

Abstract
Recently, the World Health Organization included ‘gaming disorder’ in its latest revision of the international classification of diseases (ICD-11). Despite extensive research on internet gaming disorder (IGD), few studies have addressed game-related stimuli eliciting craving, which plays an important role in addiction. Particularly, most previous studies did not consider personal preferences in games presented to subjects as stimuli. In this study, we compared neurophysiological responses elicited for favorite game (FG) videos and non-favorite game (NFG) videos. We aimed to demonstrate neurophysiological characteristics according to the game preference in the IGD group. We measured participants’ electroencephalogram (EEG) while they watched FG, NFG and neutral videos. For FG videos, the parieto-occipital theta power (TPPO) were significantly increased compared with those for NFG videos (P &lt; 0.05, paired t-test). TPPO also differed significantly between the healthy control and IGD groups only on FG videos controlling covariate (TPPO on neutral videos) (P &lt; 0.05, analysis of covariance [ANCOVA]). And TPPO was significantly correlated to self-reported craving score only on FG videos (r = 0.334, P &lt; 0.05). In the present study, we demonstrate that FG videos induce higher TPPO than that induced by NFG videos in the IGD group and TPPO is a reliable EEG feature associated with craving for gaming.
A systematic review of tailored mHealth interventions for physical activity promotion among adults
Authors: Davis Ashlee , Sweigart Ryan , Ellis Rebecca 
Published: October 2020

Abstract
The purpose of this systematic review was to critically examine the effectiveness of tailored mHealth interventions for promoting physical activity (PA) in adult populations. Cochrane Library Central Register of Controlled Trials, Medline, SportDiscus, PubMed, PsycINFO, and ProQuest databases were searched systematically in June 2019. Studies were eligible if they were experimentally designed studies, included adult populations (18+ years), and consisted of a tailored intervention that was delivered via a mobile device (i.e., cell phone, tablet). The primary outcome was change in PA. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Sixteen articles were reviewed. Ten studies reported significant positive outcomes for the intervention groups compared to the controls. Three studies reported significant improvements in PA for the tailored intervention arms compared to the non-tailored treatment arms. Four of six studies that reported no between group differences used SMS to deliver tailored materials. Differences on tailoring dimension, PA outcomes, and measurement tools were not identified between studies. Tailored mHealth interventions appear to be promising for promoting PA among adults. Most interventions used multiple intervention components. Additional research is needed to identify best practices and to make programs scalable.
A systematic review of physical activity and quality of life and well-being
Authors: Marquez David X , Aguiñaga Susan , Vásquez Priscilla M , Conroy David E , Erickson Kirk I , Hillman Charles , Stillman Chelsea M , Ballard Rachel M , Sheppard Bonny Bloodgood , Petruzzello Steven J , King Abby C , Powell Kenneth E 
Published: October 2020

Abstract
Maintaining or improving quality of life (QoL) and well-being is a universal goal across the lifespan. Being physically active has been suggested as one way to enhance QoL and well-being. In this systematic review, conducted in part for the 2018 U.S. Health and Human Services Physical Activity Guidelines for Americans Scientific Advisory Committee Report, we examined the relationship between physical activity (PA) and QoL and well-being experienced by the general population across the lifespan and by persons with psychiatric and neurologic conditions. Systematic reviews, meta-analyses, and pooled analyses from 2006 to 2018 were used for the evidence base. Strong evidence (predominantly from randomized controlled trials [RCTs]) demonstrated that, for adults aged 18–65 years and older adults (primarily 65 years and older), PA improves QoL and well-being when compared with minimal or no-treatment controls. Moderate evidence indicated that PA improves QoL and well-being in individuals with schizophrenia and Parkinson’s disease, and limited evidence indicated that PA improves QoL and well-being for youth and for adults with major clinical depression or bipolar disorder. Insufficient evidence existed for individuals with dementia because of a small number of studies with mixed results. Future high-quality research designs should include RCTs involving longer interventions testing different modes and intensities of PA in diverse populations of healthy people and individuals with cognitive (e.g., dementia) and mental health conditions (e.g., schizophrenia) to precisely characterize the effects of different forms of PA on aspects of QoL and well-being.
Photoperiod-dependent transcriptional modifications in key metabolic pathways in Coffea arabica
Authors: Djerrab Doâa , Bertrand Benoît , Breitler Jean-Christophe , Léran Sophie , Dechamp Eveline , Campa Claudine , Barrachina Célia , Conejero Geneviève , Etienne Hervé , Sulpice Ronan 
Published: October 2020

Abstract
Photoperiod length induces in temperate plants major changes in growth rates, morphology and metabolism with, for example, modifications in the partitioning of photosynthates to avoid starvation at the end of long nights. However, this has never been studied for a tropical perennial species adapted to grow in a natural photoperiod close to 12 h/12 h all year long.
We grew Coffea arabica L., an understorey perennial evergreen tropical species in its natural 12 h/12 h and in a short 8 h/16 h photoperiod, and we investigated its responses at the physiological, metabolic and transcriptomic levels. The expression pattern of rhythmic genes, including core clock genes, was affected by changes in photoperiod. Overall, we identified 2859 rhythmic genes, of which 89% were also rhythmic in Arabidopsis thaliana L. Under short-days, plant growth was reduced, and leaves were thinner with lower chlorophyll content. In addition, secondary metabolism was also affected with chlorogenic acid and epicatechin levels decreasing, and in agreement, the genes involved in lignin synthesis were overexpressed and those involved in the flavanol pathway were underexpressed.
Our results show that the 8 h/16 h photoperiod induces drastic changes in morphology, metabolites and gene expression, and the responses for gene expression are similar to those observed in the temperate annual A. thaliana species.
Short photoperiod induces drastic changes in gene expression, metabolites and leaf structure, some of these responses being similar to those observed in A. thaliana.
Differential determinants of growth rates in subtropical evergreen and deciduous juvenile trees: carbon gain, hydraulics and nutrient-use efficiencies
Authors: Qi Jin-Hua , Fan Ze-Xin , Fu Pei-Li , Zhang Yong-Jiang , Sterck Frank 
Published: October 2020

Abstract
Growth rate varies across plant species and represents an important ecological strategy for competition, resource-use and fitness. However, empirical studies often show a low predictability of functional traits to tree growth. We measured stem diameter and height growth rates (DGRs and HGRs) of 96 juvenile trees (2–5 m tall) of eight evergreen and eight deciduous broadleaf tree species over three consecutive years in a subtropical forest in south-western China. We examined the relationships between tree growth rates and 20 leaf/stem traits that are associated with carbon gain, stem hydraulics and nutrient-use efficiency, as well as the difference between evergreen and deciduous trees. We found that cross-species variations of stem DGR/HGR can be predicted by leaf photosynthetic capacity, leaf mass per area, xylem-theoretical-specific hydraulic conductivity, wood density (WD) and photosynthetic-nutrient-use efficiencies. Higher leaf carbon assimilation and lower leaf/stem constructing costs facilitate deciduous species to be more resource acquisitive and consequently faster growth within a relatively shorter growing season, whereas evergreen species exhibit more conservative strategies and thus slower growth. Furthermore, stem growth rates of evergreen species showed were more dependence on leaf carbon gains, whereas stem hydraulic efficiency was more important for deciduous tree growth. Our results suggest that physiological traits (photosynthesis, hydraulics and nutrient-use efficiency) can predict tree diameter and height growth of subtropical tree species. The differential resource acquisition and use strategies and their associations with tree growth between evergreen and deciduous trees provide insights into explaining the coexistence of evergreen and deciduous tree species in subtropical forests.
Sap flow, xylem anatomy and photosynthetic variables of threePerseaspecies in response to laurel wilt
Authors: Castillo-Argaez Raiza , Vazquez Aime , Konkol Joshua L , Vargas Ana I , Ploetz Randy C , Etxeberria Edgardo , Schaffer Bruce 
Published: October 2020

AbstractLaurel wilt, a lethal vascular wilt disease caused by the fungus Raffaelea lauricola, affects several tree species in the Lauraceae, including three Persea species. The susceptibility to laurel wilt of two forest tree species native to the southern USA, Persea borbonia and Persea palustris, [(Raf.) Sarg.] and avocado, Persea americana (Mill.) cv Waldin, was examined and related to tree physiology and xylem anatomy. Net CO2 assimilation (A), stomatal conductance (gs), leaf chlorophyll index (LCI), leaf chlorophyll fluorescence (Fv/Fm), xylem sap flow, theoretical stem hydraulic conductivity (Kh) and xylem vessel anatomy were assessed in trees of each species that were inoculated with R. lauricola and in control trees. Laurel wilt caused a reduction in A, gs, LCI, Fv/Fm and blockage of xylem vessels by tyloses formation that negatively impacted Kh and sap flow in all Persea species. However, disease susceptibility as indicated by canopy wilting and sapwood discoloration was less pronounced in P. americana cv Waldin than in the two forest species. Xylem vessel diameter was significantly smaller in P. borbonia and P. palustris than in P. americana cv Waldin. Differences in laurel wilt susceptibility among species appear to be influenced by physiological and anatomical tree responses.
Global immunoglobulin supply: steaming towards the iceberg?
Authors: Prevot Johan , Jolles Stephen 
Published: October 2020

Purpose of review
This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific areas of growth in immunoglobulin use are identified alongside novel therapies, which may reduce demand for some immunoglobulin indications.

Recent findings
There has been a 6--8% annual growth in immunoglobulin use. Secondary immunodeficiency alongside improved recognition and diagnosis primary immunodeficiency disorders are drivers whereas the novel neonatal Fc receptor inhibitors (FcRni) may reduce demand for some immunomodulatory indications.

Summary
There is a significant geographical imbalance in global supply of plasma with 65% collected in the United States. This results in a dependency of other countries on United States supply and argues for both more plasma supply and greater regionally balanced plasma collection. In addition, progress towards a transparent, regulated and well tolerated framework for the coexistence of unpaid and compensated plasma donations is needed as unpaid donation will not be sufficient. These discussions should be informed by the needs of patients for this life-saving therapy, the care of donors and the safety of plasma and PDMPs.
Open Reduction and Primary Subtalar Arthrodesis for Acute Intra-articular Displaced Calcaneal Fractures
Authors: Schipper Oliver N. , Cohen Bruce E. , Davis William H. , Ellington John Kent , Jones Carroll P. 
Published: October 2020

Objective:
To evaluate the rate of subtalar arthrodesis based on a computed tomography (CT) scan after open reduction and primary subtalar arthrodesis for acute, displaced, intra-articular calcaneal fractures.

Design:
Retrospective chart review.

Setting:
Single tertiary care practice.

Patients:
A retrospective chart review was performed to identify patients who sustained an acute, displaced, intra-articular calcaneal fracture and underwent open reduction and primary subtalar arthrodesis. Thirty-five patients participated in the study.

Intervention:
Each patient included in the study was treated with open reduction and primary subtalar arthrodesis.

Main Outcome Measures:
All patients were evaluated with CT for arthrodesis of the posterior facet of the subtalar joint, which was quantitated. Other outcome measures included radiographic parameters, the Veterans RAND Item Health Survey, and the Foot and Ankle Ability Measure.

Results:
The median patient age was 47.8 years (range 21.5–79.5 years). The median patient follow-up was 34.4 months (range 4.6–104.1 months). The Sanders classification was as follows: 3% (1/35) type II, 40% (14/35) type III, and 57% (20/35) type IV. Based on a CT scan, primary subtalar union occurred in 94.3% (33/35) of patients.

Conclusions:
Open reduction and primary subtalar arthrodesis for acute, displaced, intra-articular calcaneus fractures has a high rate of union and good pain and function outcomes. It should be strongly considered for patients with significant cartilage injury and comminution of the posterior facet.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
The Efficacy of Lumbar Hybrid Fusion for the Prevention of Adjacent Segment Disease
Authors: Cho Hyun-Jae , Ko Young San , Won Young Il , Lee Chang-Hyun , Yang Seung Heon , Kim Chi Heon , Chung Chun Kee 
Published: October 2020

Study Design:
A systematic literature review and meta-analysis

Objective:
The aim of this study is to compare hybrid constructs with traditional fusion-only constructs for the incidence of adjacent segment degeneration (ASDeg) and clinical outcomes in patients with degenerative lumbar diseases.

Summary of Background Data:
Spinal fusion is a standard surgery for various pathologies of the lumbar spine, which results in changes to the biomechanics of the spine, potentially leading to ASDeg. Although ASDeg can occur slowly as a natural course, early-onset ASDeg is regarded to be related to fusion surgery.

Materials and Methods:
A systematic search was conducted to identify studies that match the purpose. Included studies were compared using the incidence of ASDeg, Oswestry Disability Index, Visual Analog Score, and perioperative outcomes. We calculated the Peto odds ratio and mean difference (MD) for the continuous variables, respectively. In the hybrid group, subgroup analysis was also performed among devices.

Results:
Among 10 papers involving 767 patients, 372 patients underwent hybrid fusion and 395 patients underwent fusion-only. ASDeg occurred in 10.2% in the hybrid and 21.5% in the fusion-only group [Peto odds ratio, 0.39; 95% confidence interval (CI), 0.23–0.64]. The MD for Visual Analog Score were 0.45 (95% CI, 0.05–0.85) between 2 groups, which was statistically significant but was too small to have clinical significance. The MD for Oswestry Disability Index was 0.93 (95% CI, −1.016 to 2.872), which was not statistically different between 2 groups. The hybrid is superior for 18 minutes (95% CI, 5.78–30.72) shorter than typical surgery.

Conclusions:
Hybrid lumbar surgery decreased the incidence of early-onset ASDeg for about 2 years of follow-up. Among the hybrid constructs, the interspinous devices group accomplished favorable results with a lower risk. Adjacent segment disease was not as statistically significant as ASDeg, but adjacent segment disease may show a substantial difference for >2-year follow-up.