bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical, hormonal and metabolic parameters in women with PCOS with different combined oral contraceptives (containing chlormadinone acetate versus drospirenone)
Authors: Podfigurna A. , Meczekalski B. , Petraglia F. , Luisi S. 
Published: October 2019

AbstractIntroductionPolycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5–10% of women of reproductive age. It is characterized by chronic anovulation leading to menstrual disorders, and increased infertility. The syndrome can also manifest as hirsutism and acne.Aim of the studyThe aim of the study was to compare, over a duration of 6 months, the effects of drospirenone (DRSP) versus chlormadinone acetate (CMA) containing oral contraceptives (OCs) on clinical, hormonal, and metabolic parameters in 120 PCOS women.Materials and methods120 women with the diagnosis of PCOS according to the Rotterdam 2003 criteria were recruited to the study. All patients were divided to two treatment groups of OCs, containing: 3 mg DRSP/30 mcg EE (ethinylestradiol) (60 patients) and 2 mg CMA/30 mcg EE (60 patients). Clinical parameters such as hirsutismus and acne were evaluated. Metabolic parameters such as serum insulin, glucose concentration, homeostatic model assessment of insulin resistance, body mass index, systolic and diastolic blood pressures were also measured. Among hormonal parameters, serum estradiol, luteinizing hormone, follicle-stimulating hormone, prolactin, testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone, and free thyroxine were measured.ResultsThe use of both DRSP- or CMA-containing OCs provided similar positive therapeutic effects with regard to clinical, metabolic, and hormonal parameters. Among clinical parameters, like hirsutismus, after 6 months of continuous OC treatment, a statistically significant improvement was observed in both groups: DRSP (p <  0.0001) and CMA OC treatment (p < 0.0001). In addition, significant improvement was showed according to acne lesions both after DRSP (p < 0.0001) and CMA treatments (p < 0.0001). Among glucose, insulin levels and HOMA-IR, there were statistically significant higher levels in both groups after DRSP (p < 0.0001,p < 0.0001,p < 0.05) and CMA OC treatment (p < 0.02,p < 0.0001,p < 0.0001). Hormonal parameters such as LH, FSH, prolactin, testosterone and DHEA-S were statistically significant lower in both groups after DRSP (p < 0.0001,p < 0.0001,p < 0.01,p < 0,002, andp < 0.0001) and CMA OC treatment (p < 0.0001,p < 0.0001,p < 0.04,p < 0.002, andp < 0.0001).ConclusionsFurther research, however, is needed not only to define optimal duration, and to clarify the effects of treatment on long-term metabolic outcomes, but also to explore different treatment options and possible combined therapies.
Community structure based on circular flow in a large-scale transaction network
Authors: Kichikawa Yuichi , Iyetomi Hiroshi , Iino Takashi , Inoue Hiroyasu 
Published: October 2019

Abstract
The objective of this study is to shed new light on the industrial flow structure embedded in microscopic supplier-buyer relations. We first construct directed networks from actual data from interfirm transaction relations in Japan; as one example, the dataset compiled by the Tokyo Shoko Research, Ltd. in 2016 contains five million links between one million firms. Then, we analyze the industrial flow structure of such a large-scale network with a special emphasis on its hierarchy and circularity. The Helmholtz-Hodge decomposition enables us to break down the flow on a directed network into two flow components: gradient flow and circular flow. The gradient flow between a pair of nodes is given by the difference of their potentials obtained by the Helmholtz-Hodge decomposition. The gradient flow runs from a node with higher potential to a node with lower potential; hence, the potential of a node shows its hierarchical position in a network. On the other hand, the circular flow component illuminates feedback loops built in a network. The potential values averaged over firms classified by the major industrial category describe hierarchical characteristics of sectors. The ordering of sectors according to the potential agrees well with the general idea of the supply chain. We also identify industrially integrated clusters of firms by applying a flow-based community detection method to the extracted circular flow network. We then find that each of the major communities is characterized by its main industry, forming a hierarchical supply chain with feedback loops by complementary industries such as transport and services.
Spectres of Nature in the Trail Building Assemblage
Authors: Cherrington Jim , Black Jack 
Published: October 2019

AbstractThrough research that was conducted with mountain bike trail builders, this article explores the processes by which socio-natures or ‘emergent ecologies’ are formed through the assemblage of trail building, mountain bike riding and matter. In moving conversations about ‘Nature’ beyond essentialist readings and dualistic thinking, we consider how ecological sensibilities are reflected in the complex, lived realities of the trail building community. Specifically, we draw on Morton’s (2017) notion of the ‘symbiotic real’ to examine how participants connect with a range of objects and non-humans, revealing a ‘spectral’ existence in which they take pleasure in building material features that are only partially of their creation. Such ‘tuning’ to the symbiotic real was manifest in the ongoing battle that the trail builders maintained with water. This battle not only emphasized the fragility of their trail construction but also the temporal significance of the environments that these creations were rendered in/with. In conclusion, we argue that these findings present an ecological awareness that views nature as neither static, inert or fixed, but instead, as a temporal ‘nowness’, formed from the ambiguity of being in and with nature. Ecologically, this provides a unique form of orientation that re-establishes the ambiguity between humans and nature, without privileging the former. It is set against this ecological (un)awareness that we believe a re-orientation can be made to our understandings of leisure, the Anthropocene and the nature-culture dyad.
Empowering the Peer Group to Prevent School Bullying in Kosovo: Effectiveness of a Short and Ultra-Short Version of the ViSC Social Competence Program
Authors: Arënliu Aliriza , Strohmeier Dagmar , Konjufca Jon , Yanagida Takuya , Burger Christoph 
Published: October 2019

AbstractEvidence-based anti-bullying programs are predominantly implemented in high-income countries, although there is a clear need for bullying prevention also in low- and middle-income countries. The present study reports the effectiveness of a short and ultra-short version of the ViSC Social Competence Program that was implemented in nine Kosovar schools. The ViSC program aims to empower adolescents to recognize bullying and to intervene in bullying situations. A quasi-experimental longitudinal control group design was realized to examine the effectiveness of the two program versions regarding different forms of self-reported perpetration and victimization. The short program version was implemented in 10 classes (N= 282, 52% girls,Mage= 13.45), the ultra-short program version was implemented in 13 classes (N= 354, 46% girls,Mage= 13.28), and 23 classes (N= 613, 50% girls,Mage= 13.31) served as control group. Multilevel growth models revealed intervention effects in favor of the ultra-short version when compared to the control group regarding physical victimization. All other effects were not significant. To conclude, educational and social policies supporting the implementation of evidence-based anti-bullying programs need to be issued in low- and middle-income countries, as even ultra-short versions might be effective in contexts with limited available resources.
Religious Education in Germany in Light of Religious Diversity: Constitutional Requirements for Religious Education
Authors: Wittmer Fabius , Waldhoff Christian 
Published: October 2019

AbstractIn Article 7, paragraph 3, the German Constitution provides that religious education shall be a part of the curriculum of public school. This is one of the three approaches of dealing with religious education existing today. Originally, religious education as a regular subject at public schools in Germany was only offered by the two Christian Churches—Catholic and Protestant. As the number of Christians decreased and the number of Muslims increased, the demand for Islamic religious education at public schools grew. Therefore, the question arose whether the constitutional law concerning religion is capable of facing the new challenges of religious diversity. This Article tries to answer this question with regard to the introduction of Islamic religious education as a measure of adaptiveness. In the first step, the requirements of Article 7, paragraph 3 of the Constitution posed to religious education will be outlined in order to be able to examine in the second step whether Islamic religious education may be introduced at public schools as a regular subject. In this regard, the issue of the qualification of an umbrella association as a religious society and the constitutionality of the advisory board model will be discussed.
Dementia care-giving and employment: a mixed-studies review on a presumed conflict
Authors: Neubert Lydia , König Hans-Helmut , Mietzner Claudia , Brettschneider Christian 
Published: October 2019

AbstractMany persons with dementia live at home and are cared for by their relatives. If the relatives are still employed, this can lead to higher burden and losses in their work-life. The interplay between informal care-giving and working is complex. Different studies have explored this issue, but the results have not been yet synthesised. In this mixed-studies review, we elucidate the underlying complexity. Our objective is to identify the factors related to care-giving that influence employment, and to describe their impact on dementia care-givers’ employment. We performed a literature search of primary studies using four databases and one meta-database, and retrieved English- and German-language articles. We used the Mixed Methods Appraisal Tool to assess their methodological quality. Evidence identified was synthesised by a parallel-results convergent synthesis design. We included 55 qualitative, quantitative and mixed-method studies published up to January 2018. The emerging model identified factors linked to the care recipient with dementia, the informal care-giver and the care-giving context. The impacts of these factors on care-givers’ employment are mostly negative (e.g. stopped/reduced work, decreased job performance). Nevertheless, the results provide encouraging insights as working can counterbalance care-giving strain, and managing both roles can enhance care-givers’ wellbeing. Practical efforts should focus on enabling informal care-givers to better manage the balance between care-giving and work responsibilities.
Disulphide-less crotamine is effective for formation of DNA–peptide complex but is unable to improve bovine embryo transfection
Authors: Freitas Vicente J.F. , Campelo Iana S. , Silva Mirelly M.A.S. , Cavalcanti Camila M. , Teixeira Dárcio I.A. , Camargo Luiz S.A. , Melo Luciana M. , Rádis-Baptista Gandhi 
Published: October 2019

SummaryThis study aimed to investigate the ability of disulphide-less crotamine (dLCr) to complex DNA and to evaluate whether the DNA–dLCr complex is capable of improving transfection in bovine embryos. Three experiments were performed to: (i) evaluate the formation and stability of the DNA–dLCr complex; (ii) assess the dLCr embryotoxicity by exposure of bovine embryos to dLCr; and (iii) assess the efficiency of bovine embryo transfection after microinjection of the DNA–dLCr complex or green fluorescent protein (GFP) plasmid alone (control). DNA complexation by dLCr after 30 min of incubation at 1:100 and 1:50 proportions presented higher efficiency (P < 0.05) than the two controls: native crotamine (NCr) 1:10 and lipofectamine. There was no difference between DNA–dLCr 1:25 and the controls. The DNA–dLCr complexation was evaluated at different proportions and times. In all, at least half of maximum complexation was achieved within the initial 30 min. No embryotoxicity of dLCr was verified after exposure of in vitro fertilized embryos to different concentrations of the peptide. The effectiveness of dLCr to improve exogenous gene expression was evaluated by microinjection of the DNA–dLCr complex into in vitro fertilized zygotes, followed by verification of both embryo development and GFP expression. From embryos microinjected with DNA only, 4.6% and 2.8% expressed the GFP transgene at day 5 and day 7, respectively. The DNA–dLCr complex did not increase the number of GFP-positive embryos. In conclusion, dLCr forms a complex with DNA and its application in in vitro culture is possible. However, the dLCr peptide sequence should be redesigned to improve GFP expression.
Full-spectral fitting techniques to characterise the stellar content of ultra diffuse galaxies
Authors: Ruiz-Lara Tomás , Beasley M. A. , Gallart C. , Falcón-Barroso J. , Battaglia G. , Bernard E. , Brook C. , Di Cintio A. , Florido E. , Martín-Navarro I. , Monelli M. , Pérez I. , Pinna F. , Román J. , Sánchez-Blázquez P. , Trujillo I. , Vazdekis A. 
Published: October 2019

AbstractUnderstanding the peculiar properties of Ultra Diffuse Galaxies (UDGs) via spectroscopic analysis is a challenging task that is now becoming feasible. The advent of 10m-class telescopes and high sensitivity instruments is enabling the gathering of high quality spectra even for the faintest systems. In addition, advances in the modelling of stellar populations, stellar libraries, and full-spectral fitting codes are allowing the recovery of the stellar content shaping those spectra with unprecedented reliability. In this contribution we report on the extensive tests we have carried out using the inversion code STECKMAP. The similarities between the Star Formation Histories (SFH) recovered from STECKMAP (applied to high-quality spectra) and deep Colour-Magnitude diagrams fitting (resolved stars) in two Local Group dwarf galaxies (LMC and LeoA) are remarkable, demonstrating the impressive performance of STECKMAP. We exploit the capabilities of STECKMAP and perform one of the most complete and reliable characterisations of the stellar component of UDGs to date using deep spectroscopic data. We measure radial and rotation velocities, SFHs and mean population parameters, such as ages and metallicities, for a sample of five UDG candidates in the Coma cluster. From the radial velocities, we confirm the Coma membership of these galaxies. We find that their rotation properties, if detected at all, are compatible with dwarf-like galaxies. The SFHs of the UDG are dominated by old (∼ 7 Gyr), metal-poor ([M/H] ∼ -1.1) and alpha-enhanced ([Mg/Fe]∼ 0.4) populations followed by a smooth or episodic decline which halted ∼ 2 Gyr ago, possibly a sign of cluster-induced quenching. We find no obvious correlation between individual SFH shapes and any UDG morphological properties. The recovered stellar properties for UDGs are similar to those found for DDO 44, a local UDG analogue resolved into stars. We conclude that the UDGs in our sample are extended dwarfs whose properties are likely the outcome of both internal processes, such as bursty SFHs and/or high-spin haloes, as well as environmental effects within the Coma cluster.
Molecular Composition of Local Dwarf Galaxies: Astrochemistry in Low-metallicity Environments
Authors: Nishimura Yuri , Shimonishi Takashi , Watanabe Yoshimasa , Sakai Nami , Aikawa Yuri , Kawamura Akiko , Kohno Kotaro , Yamamoto Satoshi 
Published: October 2019

AbstractTo investigate molecular composition of low-metallicity environments, we conducted spectral line survey observations in the 3 mm band toward three dwarf galaxies, the Large Magellanic Cloud, IC 10, and NGC 6822 with the Mopra 22 m, the Nobeyama 45 m and the IRAM 30 m, respectively. The rotational transitions of CCH, HCN, HCO+, HNC, CS, SO, 13CO, and 12CO were detected in all three galaxies. We found that the spectral intensity patterns are similar to one another regardless of star formation activities. Compared with Solar-metallicity environments, the molecular compositions of dwarf galaxies are characterized by (1) deficient nitrogen-bearing molecules and (2) enhanced CCH and suppressed CH3OH. These are interpreted (1) as a direct consequence of the lower elemental abundance of nitrogen, and (2) as a consequence of extended photon dominated regions in cloud peripheries due to the lower abundance of dust grains, respectively.
The Future of Dwarf Galaxy Research: What Telescopes Will Discover
Authors: Haynes Martha P. 
Published: October 2019

AbstractDwarf galaxies make ideal laboratories to test galaxy evolution paradigms and cosmological models. Detailed studies of dwarfs across the spectrum allow us to gauge the efficacy of astrophysical processes at play in the lowest mass halos such as gas accretion, feedback, turbulence and chemical enrichment. Future observational studies will deliver unprecedented insights on the orbits of dwarf companions around the Milky Way, on their star formation histories and on the 3-D internal motions of their stars. Over large volumes, we will assess the impact of local environment on baryon cycling and star formation laws, leading to a full picture of the evolution of dwarfs across cosmic time. In combination, future discoveries promise to trace the history of assembly within the Local Group and beyond, probe how stars form under pristine conditions, and test models of structure formation on small scales.
Origin and Transformation of Light Hydrocarbons Ascending at an Active Pockmark on Vestnesa Ridge, Arctic Ocean
Authors: Pape T. , Bünz S. , Hong W.‐L. , Torres M. E. , Riedel M. , Panieri G. , Lepland A. , Hsu C.‐W. , Wintersteller P. , Wallmann K. , Schmidt C. , Yao H. , Bohrmann G. 
Published: October 2019

AbstractWe report on the geochemistry of hydrocarbons and pore waters down to 62.5 mbsf, collected by drilling with the MARUM‐MeBo70 and by gravity coring at the Lunde pockmark in the Vestnesa Ridge. Our data document the origin and transformations of volatiles feeding gas emissions previously documented in this region. Gas hydrates are present where a fracture network beneath the pockmark focusses migration of thermogenic hydrocarbons characterized by their C1/C2+ and stable isotopic compositions (δ2H‐CH4, δ13C‐CH4). Measured geothermal gradients (~80 °C/km) and known formation temperatures (>70 °C) suggest that those hydrocarbons are formed at depths >800 mbsf. A combined analytical/modeling approach, including concentration and isotopic mass balances, reveals that pockmark sediments experience diffuse migration of thermogenic hydrocarbons. However, at sites without channeled flow this appears to be limited to depths >~50 mbsf. At all sites we document a contribution of microbial methanogenesis to the overall carbon cycle that includes a component of secondary carbonate reduction—that is, reduction of dissolved inorganic carbon generated by anaerobic oxidation of methane in the uppermost methanogenic zone. Anaerobic oxidation of methane and carbonate reduction rates are spatially variable within the pockmark and are highest at high‐flux sites. These reactions are revealed by 13C depletions of dissolved inorganic carbon at the sulfate‐methane interface at all sites. However, 13C depletions of CH4 are only observed at the low methane flux sites because changes in the isotopic composition of the overall methane pool are masked at high‐flux sites. 13C depletions of total organic carbon suggest that at seeps sites, methane‐derived carbon is incorporated into de novo synthesized biomass.
Relating Precipitating Ice Radiative Effects to Surface Energy Balance and Temperature Biases Over the Tibetan Plateau in Winter
Authors: Lee Wei‐Liang , Li Jui‐Lin Frank , Xu Kuan‐Man , Suhas Ettamal , Jiang Jonathan H. , Wang Yi‐Hui , Stephens Graeme , Fetzer Eric , Yu Jia‐Yuh 
Published: October 2019

Key Points

Surface temperature bias is primarily determined by biases of surface radiative fluxes
Underestimated ice water path in models is related to radiation deficiency and cold bias over the Tibetan Plateau in winter
Precipitating ice radiative effects are responsible for some reduction of biases in surface radiative fluxes and temperature
Path Independence of Carbon Budgets When Meeting a Stringent Global Mean Temperature Target After an Overshoot
Authors: Tokarska Katarzyna B. , Zickfeld Kirsten , Rogelj Joeri 
Published: October 2019

AbstractEmission pathways that are consistent with meeting the Paris Agreement goal of holding global mean temperature rise well below 2 °C often assume a temperature overshoot. In such overshoot scenarios, a given temperature limit is first exceeded and later returned to, under the assumption of large‐scale deliberate carbon dioxide removal from the atmosphere. Here we show that although such strategy might result in a reversal of global mean temperature, the carbon cycle exhibits path dependence. After an overshoot, more carbon is stored in the ocean and less on land compared to a scenario with the same cumulative CO2 emissions but no overshoot. The near‐path independence of surface air temperature arises despite the path dependence in the carbon cycle, as it is offset by path dependence in the thermal response of the ocean. Such behavior has important implications for carbon budgets (i.e. the total amount of CO2 emissions consistent with holding warming to a given level), which do not differ much among scenarios that entail different levels of overshoot. Therefore, the concept of a carbon budget remains robust for scenarios with low levels of overshoot (up to 300 Pg C overshoot considered here) but should be used with caution for higher levels of overshoot, particularly for limiting the environmental change in dimensions other than global mean temperature rise.
Interplay of Subduction Tectonics, Sedimentation, and Carbon Cycling
Authors: Riedinger N. , Torres M.E. , Screaton E. , Solomon E.A. , Kutterolf S. , Schindlbeck‐Belo J. , Formolo M.J. , Lyons T.W. , Vannucchi P. 
Published: October 2019

AbstractDistinct differences were observed in geochemical signatures in sediments from two sites drilled in the upper plate of the Costa Rica margin during Integrated Ocean Drilling Program (IODP) Expedition 334. The upper 80 m at Site U1379, located on the outer shelf, shows pore water non‐steady state conditions characteristic of a declining methane flux. These contrast with analyses of the upper sediment layers at the middle slope site (U1378) that reflect steady state conditions. Distinct carbonate‐rich horizons up to 11 meters thick were recovered between 63 and 310 meters below seafloor at Site U1379 but were not found at Site U1378. The carbonates and dissolved inorganic carbon from Site U1379 have a depleted carbon stable isotope signal (up to −25‰) that indicates anaerobic methane oxidation. This inference is further supported by distinct δ34S‐pyrite and magnetic susceptibility records that reveal fluctuations of the sulfate‐methane transition in response to methane flux variations. Tectonic reconstructions of this margin document a marked subsidence event after arrival of the Cocos Ridge, 2.2 ± 0.2 million years ago (Ma), followed by increased sedimentation rates and uplift. As the seafloor at Site U1379 rose from ~2,000 m to the present water depth of ~126 m, the site moved out of the gas hydrate stability zone at ~1.1 Ma, triggering upward methane advection, methane oxidation, and the onset of massive carbonate formation. Younger carbonate occurrences and the non‐steady state pore water profiles at Site U1379 reflect continued episodic venting likely modulated by changes in the underlying methane reservoir.