bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of primary internal limiting membrane peeling in cases with rhegmatogenous retinal detachment
Authors: Abdullah Mohamed Esmail , Moharram Hossam Eldeen Mohammad , Abdelhalim Ahmed Shawkat , Mourad Khaled Mohamed , Abdelkader Mohamed Farouk 
Published: May 2020

Abstract
Background
Epiretinal membranes (ERMs) have been reported after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Peeling of the internal limiting membrane (ILM) can prevent post-PPV ERM formation but has a potential negative impact on macular structure and function.

Purpose
To investigate the anatomical and functional outcomes of ILM peeling during PPV for primary RRD.

Methods
This was a prospective nonrandomized study that included 60 eyes of 60 patients with a primary macula-off RRD and less than grade C proliferative vitreoretinopathy (PVR). Eyes were allocated into 2 groups; Group A underwent PPV without ILM peeling and Group B had ILM peeling. At postoperative month 6, all patients underwent retinal imaging using spectral domain optical coherence tomography (OCT) and OCT angiography and macular function was assessed using multifocal electroretinogram (mfERG). Baseline characteristics and postoperative anatomical and visual outcomes were recorded and statistically analyzed.

Results
We enrolled 30 eyes of 30 patients in each group. In Group A, mean age was 44.6 years, while the mean age of Group B patients was 49.9 years. Postoperative LogMAR visual acuity was significantly better in Group A than in Group B (p < 0.001). ERMs were demonstrated on OCT in 13.3% of Group A and none of Group B patients (p = 0.04). Retinal dimples were found in 53.3% of Group B and none of Group A eyes (p < 0.001). OCTA showed a greater vessel density of the superficial capillary plexus (SCP) in Group A compared to Group B eyes (p = 0.046), while no difference was found regarding deep capillary vessel density (p = 0.7). Mean amplitude of mfERG P1 wave was significantly higher in Group A eyes than in Group B (p = 0.002). Both the SCP vessel density and P1 amplitude were positively correlated with visual acuity (p < 0.001).

Conclusion
This study suggests that ILM peeling prevents ERM development in eyes undergoing PPV for uncomplicated macula-off RRD, but potential damage to macular structure and function were found.
Trial registration Retrospectively registered on 09/24/2019 on ClinicalTrials.gov with an ID of NCT04139811.
Diagnostic accuracy of cardiac MRI, FDG-PET, and myocardial biopsy for the diagnosis of cardiac sarcoidosis: a protocol for a systematic review and meta-analysis
Authors: Roth Dominik , Kadoglou Nikolaos , Leeflang Mariska , Spijker Rene , Herkner Harald , Trivella Marialena 
Published: May 2020

AbstractBackgroundCS constitutes a rare but potentially underdiagnosed and fatal disease. Its diagnosis remains difficult owing to the infrequent and indistinguishable symptoms and the lack of formal diagnostic criteria dependent upon the diagnostic techniques used. Early diagnosis and treatment, however, may help to counter its poor prognosis.We aim to characterize and compare the diagnostic accuracy of cardiac MRI, FDG-PET and myocardial biopsy for the diagnosis of cardiac sarcoidosis and to advance and compare methods for complex diagnostic test accuracy reviews and meta-analysis.MethodsFollowing a systematic review on DTA studies on the aforementioned topic, a four-part approach to meta-analysis will be used: (1) direct comparison of index tests with clinical reference standard, (2) indirect comparison of index tests with clinical reference standard, (3) addition of an alternative test to that indirect comparison (4) and Bayesian meta-analysis using results of part 3 as informative prior for comparisons analogous to part 1 and 2.DiscussionThe most widely recognized diagnostic algorithm for cardiac sarcoidosis is considered out of date, as it precedes the introduction of imaging techniques in diagnostic pathways. These novel imaging techniques, like CMR and FDG-PET scan, have emerged as promising diagnostic tools which may fill the current diagnostic gap. Thus, a systematic review and evaluation of CS diagnosis are much needed. Such an attempt is anticipated to alter the current diagnostic guidelines for CS by shedding more light on the role of sophisticated imaging techniques on prompt CS therapy and follow-up.Trial registrationPROSPERO,CRD42019047126
Patients’ perspectives of endometriosis-related fatigue: qualitative interviews
Authors: DiBenedetti Dana , Soliman Ahmed M. , Gupta Catherine , Surrey Eric S. 
Published: May 2020

Abstract
Background
Endometriosis-related fatigue is common and negatively impacts multiple areas of many women’s lives, particularly in day-to-day activities, social activities, physical activities, mood and emotions, relationships with family or partners, and work or school. Multiple studies have documented fatigue as a significant symptom of endometriosis. Additional research is needed to better understand endometriosis-related fatigue and its impacts on patients.

Methods
This qualitative study consisted of individual in-person semistructured interviews conducted with 22 adult females reporting moderate to severe endometriosis-related pain. Women with self-reported, surgically confirmed endometriosis and moderate to severe endometriosis-related pain were recruited from qualitative research firms in two locations in the United States. Qualified subjects participated in semistructured interviews that lasted approximately 45 min each. Interviews were audio recorded and transcribed for qualitative analysis.

Results
All 22 participants reported experiencing fatigue related to their endometriosis. While the degree of severity of their endometriosis-related fatigue varied, 21 of the 22 participants stated that it was at least “somewhat bothersome.” Most participants noted an impact from endometriosis-related fatigue on day-to-day activities, social activities, physical activities, mood and emotions, relationships with family or partner, and work or school.

Conclusions
The data presented here indicate that endometriosis-related fatigue has a pervasive impact on the functioning of women living with this condition. Future studies should measure any changes in fatigue that may be associated with treatment for endometriosis.
Reference values for and interpretation of the Singapore Caregiver Quality of Life Scale: a quantile regression approach
Authors: Cheung Yin Bun , Neo Shirlyn H. S. , Yang Grace M. , Teo Irene , Lee Geok Ling , Qu Debra L. M. , Koh Audrey R. X. , Thumboo Julian , Wee Hwee Lin 
Published: May 2020

Abstract
Purpose
The Singapore Caregiver Quality of Life Scale (SCQOLS) was recently developed and validated in two languages - English and Chinese. The total and domain scores are scaled to range from 0 to 100. However, the scale is not at the interval-ratio level of measurement. To facilitate interpretation, we established the percentiles of the scale’s total and domain scores among family caregivers of patients with advanced cancers and demonstrate the effect size in terms of differences in relation to caregiver and patient characteristics.

Methods
Data were drawn from a cross-sectional survey of family caregivers of patients with stage III or IV solid cancers in Singapore. Quantile regression was used to estimate the percentiles in relation to caregiver and patient characteristics.

Results
Participants in adjacent categories of patient’s performance status and caregiver’s having other family members to share caregiving duties differed by 3 to 5 points in median quality of life total score and most domain scores (each Bonferroni-adjusted P, P[B], < 0.05). Ethnicity was associated with the Physical Well-being and Experience & Meaning domain scores (each P[B] < 0.05), with variable direction and magnitude. Education was associated with Mental Well-being and Financial Well-being (each P[B] < 0.05). Equations and examples for calculation of the percentiles are provided.

Conclusion
Percentiles and effect size estimates are provided to facilitate interpretation of the SCQOLS.
Succinate dehydrogenase SDH1–1 positively regulates cotton resistance to Verticillium dahliae through a salicylic acid pathway
Authors: ZHANG Xiangyue , FENG Zili , ZHAO Lihong , LIU Shichao , WEI Feng , SHI Yongqiang , FENG Hongjie , ZHU Heqin 
Published: May 2020

Abstract
Background
Verticillium wilt, caused by the soil-borne fungus of Verticillium dahliae Kleb., is one of the most devastating diseases of cotton. The complex mechanism underlying cotton resistance to Verticillium wilt remains uncharacterized. Identifying an endogenous resistance gene may be helpful to control this disease. Previous studies revealed that succinate dehydrogenase (SDH) is involved in reactive oxygen species (ROS)-induced stress signaling pathway that is likely to be triggered by salicylic acid (SA). Here, through the metabolomics and differential expression analyses in wilt-inoculated cotton (Gossypium hirsutum), we noticed that GhSDH1–1 gene in cotton may play an important role in the resistance to V. dahlia. Then we reported GhSDH1–1 gene and its functional analysis in relation to the resistance of cotton to V. dahliae.

Results
The GhSDH1–1 gene in cotton root was significantly up-regulated after V. dahlia inoculation, and its expression level peaked at 12 and 24 h post-infection. SA can also induce the up-regulation of GhSDH1–1. Additionally, the functional analysis showed that GhSDH1–1-silenced cotton was more susceptible to V. dahliae than the control because of the significant decrease in abundance of immune-related molecules and severe damage to the SA-signaling pathway. In Arabidopsis thaliana, high expression of GhSDH1–1 conferred high resistance to V. dahliae. Arabidopsis that overexpressed GhSDH1–1 had higher resistance to V. dahliae infection compared with the wild-type.

Conclusions
Our findings provide new insights into the role of GhSDH1–1; it positively regulates cotton resistance to Verticillium wilt. The regulatory mechanism of GhSDH1–1 is closely related to SA-related signaling pathway.
Does electricity consumption impacting financial development? Wavelet analysis
Authors: Matar Ali 
Published: May 2020

AbstractThe current study analyzes the time–frequency dependencies between financial development (FD) and electrical power consumption (EPC) in the Gulf Cooperation Council (GCC) Countries (Qatar, Saudi Arabia, Kuwait, the United Arab Emirates, Oman, and Bahrain) during the period 1980–2017. The practical examination is based on the wavelet squared coherence that allows assessing the co-movement between the selected variables of FD and EPC. The main objective of this study is to investigate the short- and long-term dependencies between FD for the GCC countries and EPC to provide helpful insights to policy makers, investors, and government to show them if FD is influenced by EPC in GCC countries. Most of previous related studies have employed co-integration, causality, and panel data techniques. However, this study will be the first study that uses the wavelet coherence analysis to examine the relationship between EPC and FD. The results show periodic changes in the model of the co-movements especially after 2008 for all countries at comparatively high frequencies. Besides, the results indicate strength of co-movement varies by country. Such as a high degree of co-movement between the electrical power consumption and financial development in United Arab Emirates, Kingdom of Saudi Arabia, and Qatar, while low co-movement with Kuwait and Bahrain. The result as well document a comprehensive change in electrical power consumption and financial development co-movement after 2008 at comparatively low frequencies especially in Kuwait, Oman, and Bahrain. The results of the current study provide prospective importance implications for policy makers in improving energy plans for GCC countries that redound to EPC depression policies whereas conserving financial development.
Enhancing the Quality of Hierarchic Relations in the National Cancer Institute Thesaurus to Enable Faceted Query of Cancer Registry Data
Authors: Cui Licong , Abeysinghe Rashmie , Zheng Fengbo , Tao Shiqiang , Zeng Ningzhou , Hands Isaac , Durbin Eric B. , Whiteman Lori , Remennik Lyubov , Sioutos Nicholas , Zhang Guo-Qiang 
Published: May 2020

PURPOSE To audit and improve the completeness of the hierarchic (or is-a) relations of the National Cancer Institute (NCI) Thesaurus to support its role as a faceted system for querying cancer registry data. METHODS We performed quality auditing of the 19.01d version of the NCI Thesaurus. Our hybrid auditing method consisted of three main steps: computing nonlattice subgraphs, constructing lexical features for concepts in each subgraph, and performing subsumption reasoning with each subgraph to automatically suggest potentially missing is-a relations. RESULTS A total of 9,512 nonlattice subgraphs were obtained. Our method identified 925 potentially missing is-a relations in 441 nonlattice subgraphs; 72 of 176 reviewed samples were confirmed as valid missing is-a relations and have been incorporated in the newer versions of the NCI Thesaurus. CONCLUSION Autosuggested changes resulting from our auditing method can improve the structural organization of the NCI Thesaurus in supporting its new role for faceted query.
Effects of a Communication Intervention Randomized Controlled Trial to Enable Goals-of-Care Discussions
Authors: Bickell Nina A. , Back Anthony L. , Adelson Kerin , Gonsky Jason P. , Egorova Natalia , Pintova Sofya , Lin Jenny J. , Kozuch Peter , Bagiella Emilia , Smith Cardinale B. 
Published: May 2020

PURPOSE: Patients with advanced cancer often have a poor understanding of cancer incurability, which correlates with more aggressive treatment near the end of life (EOL). We sought to determine whether training oncologists to elicit patient values for goals-of-care (GoC) discussions will increase and improve these discussions. We explored its impact on use of aggressive care at EOL. METHODS: We enrolled and used block randomization to assign 92% of solid tumor oncologists to 2-hour communication skills training and four coaching sessions. We surveyed 265 patient with newly diagnosed advanced cancer with < 2-year life expectancy at baseline and 6 months. We assessed prevalence and quality of GoC communication, change in communication skills, and use of aggressive care in the last month of life. RESULTS: Intervention (INT) oncologists’ (n = 11) skill to elicit patient values increased (27%-55%), while usual care (UC) oncologists’ (n = 11) skill did not (9%-0%; P = .01). Forty-eight percent (n = 74) INT v 51% (n = 56) UC patients reported a GoC discussion ( P = .61). There was no difference in the prevalence or quality of GoC communication between groups (global odds ratio, 0.84; 95% CI, 0.57 to 1.23). Within 6 months, there was no difference in deaths (18 INT v 16 UC; P = .51), mean hospitalizations (0.47 INT v 0.42 UC; P = .63), intensive care unit admissions (5% INT v 9% UC; P = .65), or chemotherapy (26% INT v 16% UC; P = .39). CONCLUSION: Use of a coaching model focused on teaching oncologists to elicit patient values improved that skill but did not increase prevalence or quality of GoC discussions among patients with advanced cancer. There was no impact on high care utilization at EOL.
Extracomunitario?
Authors: Keen Catherine 
Published: May 2020

AbstractThis essay uses Bruno Latour’s model of diplomacy from An Inquiry into the Modes of Existence (AIME), alongside the networks/worknets of actor-network theory, to discuss how the medieval Italian writers Brunetto Latini and Dante Alighieri explore experiences of political exile in their vernacular writings. It examines how the two authors reflect on the pluralities of language and community that connect them to readerships both at home and in exile, focusing especially on Brunetto’s Rettorica and Dante’s Convivio. The essay investigates Brunetto’s rhetorical doctrine and Dante’s models of vernacular knowledge sharing by drawing on AIME’s notion of the diplomat, whose measured speech helps “renegotiate the new frontiers of self and other.” It is especially concerned with the modes of engagement Latour labels as the beings of politics [POL], law [LAW], and fiction [FIC].
Sound and Vision
Authors: Campbell Emma 
Published: May 2020

AbstractAs moralized works of natural history that are simultaneously scientific and religious, medieval bestiaries combine the modes Bruno Latour terms reference [REF] and religion [REL]. Bestiaries challenge the dualisms Latour identifies as central features of Modern thinking: they foreground the mediated nature of the world, they ground their descriptions in textual traditions and religious doctrine rather than direct observation, and they represent nature as articulate rather than mute. Latour’s modes help us understand the multimodal nature of bestiaries in ways that refuse the Modern preconceptions that often determine the reception of these texts today. Bestiaries in turn expose certain Modern biases that persist in Latour’s modes of existence, most notably in the crossing of the referential and religious modes [REF•REL]. This essay explores the larger implications of this problem by focusing on the operations of the religious mode [REL] in medieval bestiaries—a mode that includes reference [REF] but does not cross with it as a separate mode. Latour’s dismantling of the Modern opposition between world and words invites a reassessment of how we conceptualize the agency of language in the modes of existence.
Bruno Latour and the Loving Assumptions of [REL]
Authors: Bernau Anke 
Published: May 2020

AbstractIn An Inquiry into the Modes of Existence, which addresses itself to the profound challenge of how to “compose” a common world in the Anthropocene, Bruno Latour proposes that the mode of religion [REL] offers a model for all the others—that of reprise. Emerging from the practice of biblical exegesis, reprise refers to an open-ended process of meaning making opposed to the rigid certainties of fundamentalism. [REL] also contributes a concept of radical transformation through love (“conversion”). For Latour, two events from the Virgin Mary’s life—the Annunciation and the Assumption—illustrate reprise and conversion, both of which are necessary in coming to terms with monogeism, the knowledge that there is only one world. This essay examines Latour’s proposed relationship between reprise and conversion through a consideration of late medieval Marian devotion. Focusing on vernacular accounts of Mary’s Assumption, it argues that reprise leads to violent as well as loving conversions; indeed, violence can proceed in the name of love. The essay concludes that composition, reprise, and conversion come together in ways that trouble late medieval accounts of the Assumption, the mode of religion, and life in the Anthropocene.
Binocular Vision
Authors: Guynn Noah D. 
Published: May 2020

Abstract
This essay deploys Bruno Latour’s An Inquiry into the Modes of Existence and Bert States’s Great Reckonings in Little Rooms to analyze the pyrotechnics used in mystery plays to symbolize supernatural truths. On the one hand, these effects cultivated aesthetic immersion, allowing audiences to perceive stage illusions as real. On the other hand, they drew attention to their own artfulness, inviting spectators to marvel at human achievement and contemplate the possibility of misfire. This paradox encapsulates the theological ambiguities of medieval religious theater, which asked spectators to suspend disbelief in the name of conversion even as they maintained skepticism about sacred simulacra. Latour’s metaphysics allows us to see how mystery plays deployed multiple modes of existence, each of which mediated the others but could not reduce or explain them. States’s theater phenomenology shows us how mystery plays used self-given realities like flame to shuttle between human and nonhuman standpoints. If Latour rejects phenomenology for its refusal to consider the agency of the nonhuman, States’s focus on reality as resistance offers an implicit retort. I propose a rapprochement by showing that theater phenomenologists and medieval effects masters are both willing to embrace the ontological work of nonhuman actants.
VAPYRIN-like is required for development of the moss Physcomitrella patens
Authors: Rathgeb Ursina , Chen Min , Buron Flavien , Feddermann Nadja , Schorderet Martine , Raisin Axelle , Häberli Gabrielle-Yasymi , Marc-Martin Sophie , Keller Jean , Delaux Pierre-Marc , Schaefer Didier G. , Reinhardt Didier 
Published: May 2020

ABSTRACT
The VAPYRIN (VPY) gene in Medicago truncatula and Petunia hybrida is required for arbuscular mycorrhizal (AM) symbiosis. The moss Physcomitrella patens has a close homolog (VPY-like, VPYL), although it does not form AM. Here, we explore the phylogeny of VPY and VPYL in land plants, and study the expression and developmental function of VPYL in P. patens. We show that VPYL is expressed primarily in the protonema, the early filamentous stage of moss development, and later in rhizoids arising from the leafy gametophores and in adult phyllids. Knockout mutants have specific phenotypes in branching of the protonema and in cell division of the leaves (phyllids) in gametophores. The mutants are responsive to auxin and strigolactone, which are involved in regulation of protonemal branching, indicating that hormonal signaling in the mutants is not affected in hormonal signaling. Taken together, these results suggest that VPYL exerts negative regulation of protonemal branching and cell division in phyllids. We discuss VPY and VPYL phylogeny and function in land plants in the context of AM symbiosis in angiosperms and development in the moss.
Sonic hedgehog specifies flight feather positional information in avian wings
Authors: Busby Lara , Aceituno Cristina , McQueen Caitlin , Rich Constance A. , Ros Maria A. , Towers Matthew 
Published: May 2020

ABSTRACT
Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional information required for the formation of adult flight feathers in a defined spatial and temporal sequence that reflects their different identities. We also reveal that Shh signalling is interpreted into specific patterns of Sim1 and Zic transcription factor expression, providing evidence of a putative gene regulatory network operating in flight feather patterning. Our data suggest that flight feather specification involved the co-option of the pre-existing digit patterning mechanism and therefore uncovers an embryonic process that played a fundamental step in the evolution of avian flight.