bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue Plasminogen Activator Levels and Risk of Breast Cancer in a Case–Cohort Study on Italian Women: Results from the Moli-sani Study
Authors: Costanzo Simona , Parisi Roberta , De Curtis Amalia , Gamba Sara , Russo Laura , Persichillo Mariarosaria , Panzera Teresa , Marchetti Marina , Cerletti Chiara , de Gaetano Giovanni , Falanga Anna , Donati Maria Benedetta , Iacoviello Licia ,   on behalf of the Moli-sani Investigators
Published: October 2020

AbstractBackground Elevated levels of key enzymes of the fibrinolytic system, such as tissue plasminogen activator (tPA), are reported as predictors of poor outcome in cancer patients. Limited information is available about their potential predictive value for breast cancer (BC) risk in the general population.Aim We examined the association of tPA levels with BC risk in a case–cohort study including women from the prospective Moli-sani cohort.Methods A sample of 710 women (mean age: 54.6 ± 12.1 years) was selected as a subcohort and compared with 84 BC cases, in a median follow-up of 4.2 years. Incident cases of BC were validated through medical records. tPA plasma levels were measured using an enzyme-linked immunosorbent assay kit. Hazard ratio (HR) and 95% confidence interval (CI), adjusted for relevant covariates, were estimated by a Cox regression model using the Prentice method.Results Compared with the lowest quartile (<4.9 ng/mL), women in the highest quartile of tPA (>11.2 ng/mL) had increased risk of BC (HRIVvsI: 2.20, 95% CI: 1.13–4.28) after adjusted for age, smoking, education, menopause, and residence. Further adjustment for biochemical markers did not modify this association. The risk of BC increased by 34% for each increase in 1 standard deviation of log-transformed tPA levels (p = 0.046). Elevated levels of tPA were associated mainly with estrogen-receptor-positive BC (2.08, 95% CI: 1.18–3.66).Conclusion Higher levels of tPA, reported to predict cardiovascular risk, are a potential biomarker for BC risk, supporting the hypothesis of a “common soil” linking the pathogenic mechanisms of hormone-dependent tumors and cardiovascular disease.
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
Authors: Yang Peng-bo , Hou Pei-pei , Liu Fu-yuan , Hong Wen-bin , Chen Hang-zi , Sun Xiao-yu , Li Peng , Zhang Yi , Ju Cui-yu , Luo Li-juan , Wu Sheng-fu , Zhou Jia-xin , Wang Zhi-jing , He Jian-ping , Li Li , Zhao Tong-Jin , Deng Xianming , Lin Tianwei , Wu Qiao 
Published: October 2020

Significance
It is still a great challenge to identify novel therapeutic strategies for breast cancer, especially for those with treatment resistance. It was demonstrated here that nuclear receptor Nur77 was an effective drug target for breast cancer and compound Csn-B was clinically relevant by binding to Nur77 to prevent peroxisome proliferator-activated receptor-γ (PPARγ) targeting by steric hindrance, thereby inhibiting fatty acid uptake in cells and mouse models. Clinical sample analysis further supported the opposing roles of Nur77 and PPARγ in the patient prognosis of breast cancer. This study not only reveals a inhibitory function of Nur77 on fatty acid uptake for impeding tumor growth, but also identifies Csn-B as an effective therapeutic lead compound for breast cancer.
Macropinocytosis-mediated membrane recycling drives neural crest migration by delivering F-actin to the lamellipodium
Authors: Li Yuwei , Gonzalez Walter G. , Andreev Andrey , Tang Weiyi , Gandhi Shashank , Cunha Alexandre , Prober David , Lois Carlos , Bronner Marianne E. 
Published: October 2020

Significance
Membrane and cytoskeletal dynamics are critical to cell motility. Extensively studied in cell culture, their roles in cell movement in vivo are less understood, especially in higher vertebrates. We use dynamic imaging to visualize membrane and cytoskeletal behavior in migrating neural crest cells in living tissue. We found that forward movement of individual neural crest cells is accompanied by circular membrane flow, from anterior-to-posterior apically and posterior-to-anterior basally, coupled with internalization of lipid vesicles via macropinocytosis in the soma. Macropinosomes become wrapped with actin, then undergo anterograde translocation via microtubules toward the lamellipodium, resulting in its expansion. We elucidate how actin dynamics and membrane flow are interacted to drive forward locomotion of individual cells.
P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition
Authors: Vázquez-Rosa Edwin , Shin Min-Kyoo , Dhar Matasha , Chaubey Kalyani , Cintrón-Pérez Coral J. , Tang Xinmiao , Liao Xudong , Miller Emiko , Koh Yeojung , Barker Sarah , Franke Kathryn , Crosby Danyel R. , Schroeder Rachel , Emery Josie , Yin Terry C. , Fujioka Hisashi , Reynolds James D. , Harper Matthew M. , Jain Mukesh K. , Pieper Andrew A. 
Published: October 2020

Significance
Chronic neurodegeneration, a major cause of the long-term disabilities that afflict survivors of traumatic brain injury (TBI), is linked to an increased risk for late-life neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, vascular dementia, and chronic traumatic encephalopathy. Here, we report on the restoration of blood–brain barrier (BBB) structure and function by P7C3-A20 when administered 12 mo after TBI. This pharmacotherapy was associated with cessation of chronic neurodegeneration and recovery of normal cognitive function, benefits that persisted long after treatment cessation. Pharmacologic renewal of BBB integrity may thus provide a new treatment option for patients who have suffered a remote TBI, or other neurological conditions associated with BBB deterioration.
“Maleducados/Ill-mannered”during the #A28 political campaign on Twitter
Authors: Bou-Franch Patricia 
Published: October 2020

AbstractThis paper approaches the study of conflict through an examination of Spanish metapragmatic labels and comments of impoliteness on Twitter. The aim is twofold. It first aims to confirm the attributed importance of the labelmaleducado/ill-mannered in the specific context of Twitter and of digital discourse more generally, on quantitative and comparative grounds; then, it investigates this label, and the metapragmatic comments where it occurred, in a contextualized corpus of tweets compiled during the political campaign of Spain’s General Elections of April 28, 2019. The study draws from fivead hoccorpora specifically compiled from Twitter, and a general corpus of Spanish digital discourse provided by Sketch Engine. The analysis adopts a corpus-based metapragmatic approach, which combines quantitative and qualitative methods. Findings revealed thatmaleducadowas the most frequent metapragmatic label under scrutiny in the Twitter corpora and motivated the subsequent study of lay conceptualizations of this term.
Modulational instability in a one-dimensional spin–orbit coupled Bose–Bose mixture
Authors: Singh Dheerendra , Parit Mithilesh K , Raju Thokala Soloman , Panigrahi Prasanta K 
Published: October 2020

Abstract
We establish the condition of modulational instability (MI) in one-dimensional effective one-component self-bound quantum droplets and Bose–Bose (BB) mixture, coupled through spin–orbit and Rabi couplings. For the self-bound quantum droplets of effective one-component BB mixture, MI occurs for the atom density:

P
<

g

3
/
2

δ
g

2

m

2

π

2

ℏ

2

, where δg = g + g
12 with g indicate intra-atomic and g
12 inter-atomic interaction strengths. The MI growth rate of BB mixture in the presence of spin–orbit and Rabi couplings shows distinct signatures of the couplings, in the form of multiple domains of instability. In particular, we demonstrate the explicit difference in MI, between the effective one-component self-bound quantum droplets and BB mixture.
Design and control of a novel rotary shape memory alloy actuator for two degree of freedom underwater vectored thruster
Authors: Li YuTian , Liu Kai , Zhou XueFeng , Yuan Bin 
Published: October 2020

Abstract
Underwater vectored propulsion thruster is normally actuated by a step motor or a hydraulic system. The traditional actuators show an inherent shortcoming in energy consumption per volume, low space utilization and structure complexity. Shape memory alloy (SMA) based actuator is considered as a strong competitor to the traditional one, however high torque output and long movement distance to acquire high control accuracy and wide operating range still remain a big challenge. In this work, we developed an SMA-based underwater vectored thruster consisting of two motion rings and their rotary SMA actuators. Two SMA wires combined with supplementary rotation parts are utilized to drive the rotation of each motion ring. The rotary SMA actuator outputs torque that can change the angular position of underwater thruster, and the maximum angle and the response speed can be reached 38° and 1.6° s−1. The experimental results verify the feasibility of applying the rotary actuator to underwater device. Modeling the SMA rotary actuator system helps understanding the rotary process of underwater vectored thruster. Based on the system model, a control scheme integrated with an anti-windup Proportion Integral Differential (PID) controller is proposed. Its performance is compared with that of the integrating angle feedback without an anti-windup block through the simulation method. With the proposed anti-windup PID controller, the results show that the overshoot can be eliminated and the steady error is decreased to 0.01% and 0.9% at 10° and 25° respectively, reflecting that the anti-windup PID controller significantly improves the system controlling performance.
A bioelectric neural interface towards intuitive prosthetic control for amputees
Authors: Nguyen Anh Tuan , Xu Jian , Jiang Ming , Luu Diu Khue , Wu Tong , Tam Wing-kin , Zhao Wenfeng , Drealan Markus W , Overstreet Cynthia K , Zhao Qi , Cheng Jonathan , Keefer Edward W , Yang Zhi 
Published: October 2020

Abstract

Objective. While prosthetic hands with independently actuated digits have become commercially available, state-of-the-art human-machine interfaces (HMI) only permit control over a limited set of grasp patterns, which does not enable amputees to experience sufficient improvement in their daily activities to make an active prosthesis useful. Approach. Here we present a technology platform combining fully-integrated bioelectronics, implantable intrafascicular microelectrodes and deep learning-based artificial intelligence (AI) to facilitate this missing bridge by tapping into the intricate motor control signals of peripheral nerves. The bioelectric neural interface includes an ultra-low-noise neural recording system to sense electroneurography (ENG) signals from microelectrode arrays implanted in the residual nerves, and AI models employing the recurrent neural network (RNN) architecture to decode the subject’s motor intention. Main results. A pilot human study has been carried out on a transradial amputee. We demonstrate that the information channel established by the proposed neural interface is sufficient to provide high accuracy control of a prosthetic hand up to 15 degrees of freedom (DOF). The interface is intuitive as it directly maps complex prosthesis movements to the patient’s true intention. Significance. Our study layouts the foundation towards not only a robust and dexterous control strategy for modern neuroprostheses at a near-natural level approaching that of the able hand, but also an intuitive conduit for connecting human minds and machines through the peripheral neural pathways.
Clinical trial: DExterous Hand Control Through Fascicular Targeting (DEFT). Identifier: NCT02994160.
Study on Preparation and Properties of Corrosion Resistant 3D Printing Magnesium Alloy Materials
Authors: Tian Jun 
Published: October 2020

Abstract
In this paper, the medical magnesium alloy melt containing Mg, Zn, Ca, Nd elements was prepared by liquid forming technology. Through atomization, the medical magnesium alloy powder material for 3D printing was obtained. The microstructure of the alloy was observed by SEM and XRD. The corrosion resistance of the alloy was tested by electrochemistry. The final results show that the 3D printing material of medical magnesium alloy has good structure uniformity and corrosion resistance can be effectively improved by adding Nd element.
Softening Behavior and Mechanism of Laser Rapid Forming Ti-6Al-4V Alloy Deformed at the High Temperature
Authors: Sun Kun , Xiang Wenli , Xu Yuan , Shu Xinzhu 
Published: October 2020

Abstract
Using the gleeble-1500 thermal simulator, the high temperature quasi-static compression experiment on cylindrical samples of Laser Rapid Forming Ti-6Al-4V(LRF TC4) titanium alloy have been conducted. Softening behaviour and mechanism of LRF TC4 alloy deformed at different high temperatures were investigated by means of optical microscope (OM) and transmission electron microscope (TEM). It shows that, the strength of LRF TC4 was observably reduced with the rise of the deforming temperature, showing stronger thermal softening effect and superplasticity ability. Microstructure analysis on the samples deformed at the temperature from 400°C to 900°C showed that the original acicular microstructure of LRF TC4 has two significant changes: Acicular microstructure bents at the temperature from 400°C to 600°C, while acicular microstructure bents drasticly, fragmented, spheroidized at the temperature from 700°C to 900°C. No matter bending, fragmentation, or spheroidizing of acicular microstructure, stress in the deformed sample is released. Therefore, these three factors and their superimposition action were the source of thermal softening of LRF TC4 deformed at the high temperature.
Study on Bearing Capacity Performance and Influence Factors of Phyllite Soil Blended with Red Clay
Authors: Zhao Xiushao , Fu Zhitao , Yang Qijing , Geng Daxin , Wang Zhiyao 
Published: October 2020

Abstract
Phyllite soil has low bearing capacity and can not meet the mechanical properties of subgrade, so it is proposed to use special soil (red clay) to reinforce and improve phyllite soil. The shear strength indexes of unsaturated and saturated mixed soil were obtained by shear strength tests, and the ultimate bearing capacity calculation model was established based on shear strength indexes and plate load test. The calculation results show that the reduction of the ultimate bearing capacity can exceed 50% after saturation. According to the detection indexes of foundation coefficient (K
30) and the requirement of medium and long-term bearing capacity in the subgrade code, the minimum blending ratio of red clay in different filling layers of subgrade was obtained through comparison, which can provide a basis for improving special soil with special soil.
Synthesis and Characterization of Phthalocyanine Polymer Towards Nonlinear Optical Applications
Authors: Wang Jihua , Duan Qian 
Published: October 2020

Abstract
In the present study, linear poly(methyl methacrylate161-co-phthalonitrile1.5) (P(MMA161-co-CPMA1.5)) polymer was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. Then the P(MMA161-co-CPMA1.5) polymer followed by macrocyclization reaction to form poly(methyl methacrylate167-co-zinc phthalocyanine1.1) (P(MMA167-co-ZnPc1.1)) polymer. The P(MMA167-co-ZnPc1.1) polymer was characterized by fourier transform infrared, nuclear magnetic resonance, ultraviolet-visible absorption. The nonlinear optical properties of the P(MMA167-co-ZnPc1.1) polymer were investigated by using the Z-scan technique at 532 nm with 7 ns laser pulses. The results revealed that the P(MMA167-co-ZnPc1.1) polymer exhibited excellent reverse saturable absorption (RSA) performance.
Preparation and Properties of Oriented Silicon Steel Insulation Coating with Repair Function
Authors: Huang Zhenxin , Wu Lin , Liu Ying , Hu Ya , Zhang Rui , He Yuxin , Chen Jintao , Wang Ke , Yang Xiaoyu 
Published: October 2020

Abstract
In order to improve the comprehensive performance of oriented silicon steel insulation coatings and repair surface defects, an insulating coating for oriented silicon steels with repair function was prepared. The repair function was investigated by a simulation experiment. Adhesion and magnetic characteristics were measured. Corrosion resistance was tested by neutral salt spray test. The structure of the insulating coating was characterized by infrared spectroscopy. Results exhibit that the coating has good performance and long service life. The surface is smooth, bright and even, the adhesion is A and the coating is able to embellish the defects of crystal exposing on the matrix layer. There is no corrosion occurred after 24h salt spray test; the magnetic induction intensity B800 is 1.81T, which meets the technical requirements of domestic steel mill products.
Early-age Shrinkage-induced Cracking Prevention of Cast-in-place Concrete of Subway Station under Marine Environmental Conditions
Authors: Liu Quanwei , Zhang Jian , Xu Wen , Wang Yujiang , Wang Hongbo , Wen Quan 
Published: October 2020

Abstract
Early-age cracking and leakage phenomena has became a serious problem for cast-in-place concrete of underground station in marine environment, in the present work, an anti-cracking admixture (HME-V) with temperature rise inhibition and micro-expansion properties were adopted to mitigate shrinkage cracking risk. Results indicated that the usage of HME-V exhibits larger expansion behavior not only at temperature rise period but also at temperature fall period, leading to the compensation of real-time shrinkages in concrete. Meanwhile, the early adiabatic temperature rise rate can be significantly reduced with no influence on final value. As a result, the temperature peak value and average cooling rate of the field concrete were decreased by 21.0% and 24.2% respectively. In addition, the usage of HME-V displays considerable impact on early-age compressive strength and but made no difference to the later ones. As no visible cracks and water leakage were observed in the sidewall structure, this work may prove a feasible approach to prevent early-age shrinkage crack of cast-in-place concrete used for underground station.
Effect of Steel Fiber on Fluidity and Compressive Strength of Ultra-high Performance Concrete
Authors: Wang Yanan , Yu Genshe , Wang Jue , Liu Yonghui 
Published: October 2020

Abstract
The influence of steel fiber content on concrete fluidity and compressive strength was studied through the slump, expansion and compressive strength tests of ultra-high performance concrete specimens with different steel fiber content. The results show that the fluidity of concrete decreases obviously with the increase of steel fiber content, but this situation can be improved by adjusting the amount of water-reducing agent. With the increase of steel fiber content, concrete compressive strength increases obviously, but the higher the steel fiber content is, the better. When it exceeds a certain value, concrete compressive strength begins to decline.
Elastic Solution of Stress Boundary Problem for Orthotropic Materials
Authors: Jia Purong , Suo Yongyong , Jia Cheng 
Published: October 2020

Abstract
The elastic solution of common stress boundary problem is discussed for the plate with orthotropic materials. Essential equations are introduced on the basis of linear elastic mechanics and complex variable method. The complex variable functions including the material parameters are analyzed for solving the partial derivation equation and to meet the needs of the stress boundary conditions. By constructing new stress functions, the mechanic analysis of the orthotropic plate is carried out, and also the stress boundary problem is resolved. The general expressions of the stress fields are determined finally.
Study on Energy-Storing Building Materials Made of Paraffin/Montmorillonite Composites
Authors: Zhou Dunbai , Ji Fenglong 
Published: October 2020

Abstract
Phase change materials (PCM) are promising in the application for reducing building energy consumptions and increasing thermal comfort. However, PCM have not been used as building materials extensively. A major technical hindrance for the applications of PCM in building materials is the packaging of PCM. The strategies for the packaging of PCM in building materials reported in the previous studies were mostly unsatisfactory because of the disadvantages such as complex proccesses, high cost or poor packing effectiveness, etc. This study presented a novel simple and low-cost way to make energy-saving building materials with PCM. In this study, a composite containing PCM was developed with montmorillonite (MMT) and paraffin via a simple and low-cost route. Through the selection of appropriate raw materials and with the vigorously mixing using a high-shear mixer, the PCM/MMT composites were prepared simply. The thermal properties of the PCM/MMT composites were investigated by differential scanning calorimetry (DSC). Based on the thermal properties and packing effectiveness the weight ratio of PCM: MMT = 5:4 was determined as the appropriate composition of the PCM/MMT composites. As compared with the PCM composites made of organically modified MMT, the PCM/MMT composites prepared in this study exhibited higher compression strength. The thermal conductive performance of the wallboards made of the PCM/MMT composites and the ordinary wallboards was simulated through numerical simulation. The experimental systems were also set up for testing the energy-saving characteristic of the building materials containing the PCM/MMT composites under both laboratorial conditions and natural outdoor conditions The numerical simulation as well as the experimental results indicated that the wallboard made of the PCM/MMT composite could effectively reduce the temperature fluctuation and would be favorable for keeping room in a comfortable temperature range. Hence the PCM/MMT composites might be promising for developing high-performance thermal regulating building materials with low-cost.
Review on Inorganic Materials Modified Sulfonated Poly(ether ether ketone)Membranes—Used as Proton Exchange Membranes
Authors: Gao Xiaomin 
Published: October 2020

Abstract
As proton conductor and fuel separator, the proton exchange membranes (PEMs) are important electrolyte for the proton exchange membrane fuel cell (PEMFC). The Nafion membranes, used as traditional PEMs, are limited by some disadvantages, so the sulfonated poly(ether ether ketone) (SPEEK) with good comprehensive properties is expected to replace the Nafion. In this paper, the SPEEK composite membranes modified by inorganic materials are summarized. The results show that the SiO2, CNTs and some other inorganic materials are prospective candidates for high-performance SPEEK membranes.
Dynamic Impact Damage of Oil and Gas Pipelines
Authors: Nie Hailiang , Ma Weifeng , Sha Shengyi , Ren Junjie , Wang Ke , Cao Jun , Dang Wei 
Published: October 2020

Abstract
Dynamic impact damage is one of the main causes of Oil and Gas pipeline failure, but there is no systematic research method and achievement on pipeline dynamic impact damage at present. As the weak link of pipeline, girth weld is the most important research object in practical engineering application, so it is urgent to study the damage behaviour of pipeline girth weld under dynamic impact load. This paper reviews the experimental technology of split Hopkinson Pressure Bar in the field of dynamic impact mechanics, the theoretical knowledge of stress wave propagation theory, dynamic mechanics and damage mechanics, as well as the finite element simulation analysis method, explains the application of theory and technology in practical engineering, introduces the research status of mechanical behaviour of pipeline girth weld under dynamic impact load, and looks forward to the theoretical and technical trend of dynamic impact mechanics of pipeline girth weld. It lays a foundation for the dynamic impact safety evaluation and the establishment of protection system of pipeline girth weld.