bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on safe driving behavior of transportation vehicles based on vehicle network data mining
Authors: Sun Yuefang , Bi Yu , Han Yang , Xie Dongxue , Li Ruishan 
Published: October 2019

AbstractIn recent years, with the rapid development of China's economy and the growth of people's travel demand, road transport industry has developed rapidly. However, at the same time, the traffic safety problems caused by the accelerated growth of transport vehicles are becoming more and more serious. Driver's driving behavior is closely related to traffic safety. With the help of data mining technology, we can make full use of the system data collected by road transportation industry to identify the bad driving behavior of transport vehicles and get seven secondary indicators of traffic safety evaluation indicators: overspeed, accelerated, decelerated, fatigue driving, idle preheating, overspeed idling, and flameout taxiing. According to the indicators, the occurrence times and duration are further subdivided into 14 three‐level indicators. Then, by using the analytic hierarchy process, through the construction of comparison judgment matrix and consistency checking, the corresponding weight of each evaluation index is determined with the help of the entropy method, and the formation safety of transport vehicles is evaluated. The results show that drivers with more fatigue driving, acceleration, and deceleration have higher driving risk. Transportation enterprises and relevant departments need to focus on their monitoring. The combination of data mining, data analysis algorithm, and traffic safety field in machine learning provides a demonstration for the study of safe driving behavior of transport vehicles in China and has a guiding significance for the supervision and training of drivers' driving behavior and reducing road safety risks.
Privacy issues of android application permissions: A literature review
Authors: Shrivastava Gulshan , Kumar Prabhat , Gupta Deepak , Rodrigues Joel J. P. C. 
Published: October 2019

AbstractAndroid is an application platform for mobile devices. It comprises of the operating system, software framework, and core programs. This platform uses permissions to hide precious information about the user from untrusted apps. However, to install an application, device feature uses permissions that are granted by the user. User has the ability to analyze permissions and abort the setup if the permissions are unfriendly or unrestrained. Android permission analysis schemes show a significant role to fight against these undesirable behaviors of untrusted android apps in the aspect of security and privacy. This survey attempts to deal with the android application permissions that are related security and privacy challenges. It includes various research articles published in computers and security, digital investigation, decision support systems, systems and software security, and information forensics journals in the last 10 years. The survey is based on the following considerations: research issues motivated by the scheme, the methodology used, ability of result analysis conducted, and android features considered for performance evaluation.
Metabolic and vascular risk factors are associated with reduced cerebral blood flow and poorer midlife memory performance
Authors: MacIntosh Bradley J. , Shirzadi Zahra , Atwi Sarah , Detre John A. , Dolui Sudipto , Bryan Robert Nick , Launer Lenore J. , Swardfager Walter 
Published: October 2019

AbstractMidlife metabolic and vascular risk factors (MVRFs) predict cognitive decline and dementia; however, these risk factors tend to overlap, and the mechanisms underlying their effects on cognitive performance are not well understood. This cross‐sectional study investigates the contributions of MVRFs to regional cerebral blood flow (CBF) and verbal learning & memory among middle‐aged adults. We used partial least squares (PLS) analysis to create latent risk factor profiles and examine their associations to CBF in 93 regions of interest among 451 participants (age 50.3 ± 3.5 years) of the Coronary Artery Risk Development in Young Adults. This multivariate analysis revealed regional CBF was lower in relation to obesity (higher body mass index and waist circumference), dysregulated glucose homeostasis (higher fasting glucose, oral glucose tolerance, and higher fasting insulin), and adverse fasting lipid profile (lower high‐density lipoprotein cholesterol and higher triglycerides). In a sensitivity analysis, we found that significant associations between MVRFs and CBF were prominent in the hypertension‐medicated subgroup. In a mediation model, the PLS‐based MVRFs profile was associated with memory performance (rey auditory verbal learning test); however, CBF was not a significant mediator of this association. The results describe an adverse midlife metabolic profile that might set the stage for incipient dementia and contribute to widespread changes in CBF.
N‐Silylation of Amines Mediated by Et3SiH/KOtBu
Authors: Palumbo Fabrizio , Rohrbach Simon , Tuttle Tell , Murphy John A. 
Published: October 2019

AbstractSilylation of primary and secondary amines is reported, using triethylsilane as the silylating reagent in the presence of potassium tert‐butoxide (KOtBu). The reaction proceeds well in the presence of 0.2 equiv. of KOtBu. In competition experiments, aniline is selectively silylated over aliphatic amines. Computational studies support a catalytic mechanism which is initiated by KOtBu interacting with the silane to form KH and silylated amine. The KH then takes over the role of base in the propagation of the cyclic mechanism and deprotonates the amine. This reacts with R3SiH to afford the product R3SiNR′R′′ and regenerate KH.
Observed trends and relationships between ENSO and standardized hydrometeorological drought indices in central Chile
Authors: Oertel Melanie , Meza Francisco Javier , Gironás Jorge 
Published: October 2019

AbstractDroughts are natural phenomena that severely affect socio economic and ecological systems. In Chile, population and economic activities are highly concentrated in its central region (i.e. between latitudes 29°S and 40°S), which periodically suffers from severe droughts affecting agriculture, hydropower, and mining. Understanding the dynamics of droughts and large‐scale atmospheric processes that influence the occurrence of dry spells is essential for forecasting and efficient early detection of drought events. Central Chile's climate is marked by a significant El Niño Southern Oscillation (ENSO) influence that might help to better characterize droughts as well as to identify the effects of ENSO on the spatial and temporal characteristics of meteorological and hydrological droughts in the region. We analysed the behaviour of the Standardized Precipitation Evapotranspiration Index (SPEI) and Standardized Streamflow Index (SSI) time series for 6‐month accumulation periods over the austral winter and summer seasons. Multiple linear regression (MLR) and Generalized Linear Models (GLM) showed a significant ENSO influence on dry events for SPEI‐6 and SSI‐6 during winter and summer. We found that the magnitude of correlation between ENSO and SPEI‐6 has changed over the last decades becoming weaker in winter periods and increasing in spring summer periods. Increasing trends in meteorological and hydrological drought events were also identified, along all latitudes, with significant trends during winter in the southern latitudes, and during summer in the semi‐arid and Mediterranean zones. These results indicate that drought mitigation actions and policies are necessary to overcome their adverse effects. Given the monthly persistence of ENSO and its relationship to drought indices, there are opportunities for drought monitoring and seasonal forecasting that could become part of national drought management systems.
A distributed analysis of lateral inflows in an Alaskan Arctic watershed underlain by continuous permafrost
Authors: King Tyler V. , Neilson Bethany T. , Overbeck Levi D. , Kane Douglas L. 
Published: October 2019

AbstractLateral inflows control the spatial distribution of river discharge, and understanding their patterns is fundamental for accurately modelling instream flows and travel time distributions necessary for evaluating impacts of climate change on aquatic habitat suitability, river energy budgets, and fate of dissolved organic carbon. Yet, little is known about the spatial distribution of lateral inflows in Arctic rivers given the lack of gauging stations. With a network of stream gauging and meteorological stations within the Kuparuk River watershed in northern Alaska, we estimated precipitation and lateral inflows for nine subcatchments from 1 July to 4 August,2013, 2014, and 2015. Total precipitation, lateral inflows, runoff ratios (area‐normalized lateral inflow divided by precipitation), percent contribution to total basin discharge, and lateral inflow per river kilometre were estimated for each watershed for relatively dry, moderate, or wet summers. The results show substantial variability between years and subcatchments. Total basin lateral inflow depths ranged 24‐fold in response to a threefold change in rainfall between dry and wet years, whereas within‐basin lateral inflows varied fivefold from the coastal plain to the foothills. General spatial trends in lateral inflows were consistent with previous studies and mean summer precipitation patterns. However, the spatially distributed nature of these estimates revealed that reaches in the vicinity of a spring‐fed surficial ice feature do not follow general spatial trends and that the coastal plain, which is typically considered to produce minimal runoff, showed potential to contribute to total river discharge. These findings are used to provide a spatially distributed understanding of lateral inflows and identify watershed characteristics that influence hydrologic responses.
Midazolam inhibits proliferation and accelerates apoptosis of hepatocellular carcinoma cells by elevating microRNA‐124‐3p and suppressing PIM‐1
Authors: Qi Yanyan , Yao Xiangyan , Du Xianhui 
Published: October 2019

AbstractObjectiveRecently, the impact of microRNAs (miRNAs) has been identified in hepatocellular carcinoma (HCC), this study was designed to assess the effects of miR‐124‐3p and midazolam (MDZ) in HCC with the involvement of PIM‐1.MethodsHepG2 human HCC cells were selected for our study, which were treated with different concentrations of MDZ. The gain‐ and loss‐of‐function experiments were performed to elucidate the migration, invasion, proliferation, colony formation ability, cell cycle, and apoptosis of HepG2 cells upon treatment of MDZ, miR‐124‐3p mimics, or miR‐124‐3p inhibitor. The expression levels of miR‐124‐3p, PIM‐1, Bax, Bcl‐2, P21, and Ki‐67 in HepG2 cells were assessed by reverse transcription quantitative polymerase chain reaction and western blot analysis. Moreover, HepG2 cell growth in vivo was measured by subcutaneous tumorigenesis in nude mice, and the target relation between miR‐124‐3p and PIM‐1 was evaluated using dual luciferase reporter gene assay.ResultsWe have found that after treated with overexpression of miR‐124‐3p and MDZ, there exhibited elevated miR‐124‐3p, declined expression of PIM‐1, attenuated migration, invasion, proliferation and colony formation ability, and promoted apoptosis of HepG2 cells. Additionally, it could be observed that the tumor volume and weight were all reduced upon treatment of overexpression of miR‐124‐3p and MDZ. Meanwhile, the results in the HepG2 cells that treated with down‐regulated miR‐124‐3p were the opposite. Furthermore, PIM‐1 was found to be a target gene of miR‐124‐3p.ConclusionOur study found that MDZ could inhibit proliferation and accelerate apoptosis of HCC cells by elevation of miR‐124‐3p and suppressing PIM‐1, which may be an effective method in the treatment of HCC.
GATA1 mutations in red cell disorders
Authors: Ling Te , Crispino John D. 
Published: October 2019

AbstractGATA1 is an essential regulator of erythroid cell gene expression and maturation. In its absence, erythroid progenitors are arrested in differentiation and undergo apoptosis. Much has been learned about GATA1 function through animal models, which include genetic knockouts as well as ones with decreased levels of expression. However, even greater insights have come from the finding that a number of rare red cell disorders, including Diamond–Blackfan anemia, are associated with GATA1 mutations. These mutations affect the amino‐terminal zinc finger (N‐ZF) and the amino‐terminus of the protein, and in both cases can alter the DNA‐binding activity, which is primarily conferred by the third functional domain, the carboxyl‐terminal zinc finger (C‐ZF). Here we discuss the role of GATA1 in erythropoiesis with an emphasis on the mutations found in human patients with red cell disorders.
Human amniotic fluid stem cells attract osteoprogenitor cells in bone healing
Authors: Basile Mariangela , Marchegiani Francesco , Novak Sanja , Kalajzic Ivo , Di Pietro Roberta 
Published: October 2019

AbstractCurrent treatments of large bone defects are based on autologous or allogenic bone transplantation. Human amniotic fluid stem cells (hAFSCs) were evaluated for their potential in bone regenerative medicine. In this study, hAFSCs were transduced with lentiviral vector harboring red fluorescent protein to investigate their role in the regeneration of critical‐size bone defects in calvarial mouse model. To distinguish donor versus recipient cells, a transgenic mouse model carrying GFP fluorescent reporter was used as recipient to follow the fate of hAFSCs transplanted in vivo into Healos® scaffold. Our results showed that transduced hAFSCs can be tracked in vivo directly at the site of transplantation. The presence of GFP positive cells in the scaffold at 3 and 6 weeks after transplantation indicates that donor hAFSCs can recruit host cells during the repair process. These observations help clarify the role of hAFSCs in bone tissue repair.
miR‐188‐5p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer
Authors: Wang Mei , Zhang Huiling , Yang Fang , Qiu Rong , Zhao Xinxin , Gong Zheng , Yu Wanjun , Zhou Baocheng , Shen Bo , Zhu Wei 
Published: October 2019

AbstractPreviously, serum miR‐188‐5p is differentially expressed in breast cancer, but the diagnostic potential of circulating miR‐188‐5p as well as its regulatory mechanism in breast cancer remain uncertain. Herein, serum miR‐188‐5p was detected by real‐time polymerase chain reaction in patients with breast cancer, breast fibroadenoma, and healthy subjects. Circulating miR‐188‐5p was abnormally elevated in patients with breast cancer as compared with these other two groups, and was reduced in patients with breast cancer following surgical treatment. Increased serum miR‐188‐5p corresponded to lymph node metastasis status and TNM stages of breast cancer. A receiver operating characteristic curve analysis of the ability to circulate miR‐188‐5p to distinguish between patients with breast cancer and either noncancerous patients or patients with breast fibroadenoma yielded corresponding areas under the curve of 0.894 and 8.814. miR‐188‐5p was downregulated in the highly malignant cancer line MDA‐MB‐231 relative to the less malignant MCF‐7 cells. In vitro, functional analyses conducted via transfecting cells with mimics and inhibitors revealed miR‐188‐5p to suppress breast cancer cell proliferation and migration, which was mediated by its downstream target IL6ST. Comparison of intracellular and exosomal miR‐188‐5p levels indicated that miR‐188‐5p was selectively sorted into exosomes derived from MDA‐MB‐231 cells rather than those from MCF‐7 cells. However, exosomal miR‐188‐5p levels in the serum of patients with breast cancer were reduced compared to healthy controls and did not differ relative to patients with breast fibroadenoma. In summary, miR‐188‐5p acts in a tumor‐suppressive manner in breast cancer progression and may serve as a noninvasive early diagnostic biomarker and therapeutic target in breast cancer.
Hybrid electrospun porous fibers of poly(lactic acid) and nano ZIF‐8@C600 as effective degradable oil sorbents
Authors: Wang Yating , Li Xu , Dai Xiu , Zhan Yixing , Ding Xiaoqing , Wang Ming , Wang Xinglong 
Published: October 2019

AbstractBACKGROUNDWith the rapid industrial and urbanization development, a large amount of oily wastewater is generated from various sources. It is mutagenic and carcinogenic to human health and seriously affects the ecosystem. In this study PLA/ZIF‐8@C600 nanofibers were prepared for oil adsorption.RESULTSHybrid nanoparticles (ZIF‐8@C600) of carbon black C600 and zeolitic imidazolate framework‐8 (ZIF‐8) with high specific surface area and porous structure were prepared by co‐deposition and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FITR) spectroscopy, X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), Raman spectroscopy and contact angle measurement. Biodegradable composite nanofiber membranes of poly(lactic acid) (PLA) and ZIF‐8@C600 were manufactured by electrospinning. The SEM and contact angle results showed that the addition of ZIF‐8@C600 could adjust the diameter, porosity, pore size and hydrophobicity of the composite electrospun nanofibers. The PLA/ZIF‐8@C600 porous membranes had good oil sorption properties in oil–water mixture and emulsion. The oil adsorption capacity of the sample with 1 wt% ZIF‐8@C600 was improved by ∼72.59% compared with that of pure PLA (13.5 g g−1), which demonstrated that the PLA/ZIF‐8@C600 fibers were good candidates as oil sorbents. The adsorption kinetics of the membranes on paraffin liquid was in accordance with pseudo‐second‐order kinetics.CONCLUSIONThe addition of hybrid ZIF‐8@C600 improved the hydrophobic properties and oil adsorption capacity of PLA/ZIF‐8@C600 porous membranes. Because PLA is an environmentally friendly polymer, composite membranes based on it can avoid secondary pollution. Overall, these findings have good prospects for future treatment of oily wastewater. © 2019 Society of Chemical Industry
Critical review on microbial fuel cells for concomitant reduction of hexavalent chromium and bioelectricity generation
Authors: Aarthy Mayilvahanan , Rajesh Thangamani , Thirunavoukkarasu Manikkannan 
Published: October 2019

AbstractRapid urbanization and industrialization has led to the indiscriminate discharge of heavy metals into the environment. Hexavalent chromium (Cr(VI)), a lethal, carcinogenic and genotoxic heavy metal frequently found in industrial effluent, poses a serious threat to human health. On the other hand, there is a global energy crisis prevalent owing to the scarcity of resources and huge energy demand. An emerging innovative technology which utilizes the biocatalytic activity of microbes for electron production and offers a dual solution for simultaneous reduction of Cr(VI) and generation of bioelectricity is the microbial fuel cell (MFC). The success of the MFC depends on variables such as cell configuration, pH, electrode materials, effect of microbial communities and operational conditions. This review provides a critical insight on the developments in the field of MFCs with abiotic and biotic cathodes, integrated systems, plant‐ and soil‐based designs for treatment of Cr(VI)‐laden effluent and sustainable energy recovery. © 2019 Society of Chemical Industry
Incidence and predictors of total mortality in 267 adults presenting with mitochondrial diseases
Authors: Papadopoulos Constantinos , Wahbi Karim , Behin Anthony , Bougouin Wulfran , Stojkovic Tanya , Leonard‐Louis Sarah , Berber Nawal , Lombès Anne , Duboc Denis , Jardel Claude , Eymard Bruno , Laforêt Pascal 
Published: October 2019

AbstractAssessing long‐term mortality and identifying predictors of death in adults with mitochondrial diseases. We retrospectively included adult patients with genetically proven mitochondrial diseases referred to our centre between January 2000 and June 2016, and collected information relative to their genetic testing, clinical assessments, and vital status. We performed single and multiple variable analyses in search of predictors of total mortality, and calculated hazard ratios (HR) and 95% confidence intervals (CI). We included 267 patients (women 59%; median age 43.3 [31.3‐54.2] years), including 111 with mitochondrial DNA (mtDNA) single large‐scale deletions, 65 with m.3243A>G, 24 with m.8344A>G, 32 with other mtDNA point mutations, and 36 patients with nuclear genes mutations. Over a median follow‐up of 8.9 years (0.3 to 18.7), 61 patients (22.8%) died, at a median age of 50.7 (37.9‐51.9) years. Primary cause of death was cardiovascular disease in 16 patients (26.2%), respiratory in 11 (18.0%), and gastrointestinal in 5 (8.1%). By multiple variable analysis, diabetes (HR 2.75; 95% CI 1.46‐5.18), intraventricular cardiac conduction defects (HR 3.38; 95% CI 1.71‐6.76) and focal brain involvement (HR 2.39; 95% CI 1.25‐4.57) were independent predictors of death. Adult patients with mitochondrial diseases present high morbidity that can be independently predicted by the presence of diabetes, intraventricular cardiac conduction defects, and focal brain involvement.
Supercritical fluid chromatography coupled to mass spectrometry for lipidomics
Authors: Chollet Céline , Boutet‐Mercey Stéphanie , Laboureur Laurent , Rincon Carlos , Méjean Marie , Jouhet Juliette , Fenaille François , Colsch Benoit , Touboul David 
Published: October 2019

AbstractSupercritical fluid chromatography (SFC) has experienced a particular revival in recent years thanks to the development of robust and efficient commercial systems. Because of its physico‐chemical properties, supercritical carbon dioxide (CO2) mixed with cosolvents and additives is particularly suitable for SFC to allow the elution of compounds of different polarities and more particularly complex lipids. Hyphenation with mass spectrometry (MS) is increasingly described in the literature but still requires many further developments in order to be as user‐friendly as coupling with liquid chromatography. The basic concepts of SFC and MS hyphenation will be first considered. Then a representative example of method development in lipidomics will be introduced. In conclusion, the challenges and future needs in this field of research will be discussed.
QCMS2 as a new method for providing insight into peptide fragmentation: The influence of the side‐chain and inter–side‐chain interactions
Authors: Cautereels Julie , Van Hee Nils , Chatterjee Sneha , Van Alsenoy Christian , Lemière Filip , Blockhuys Frank 
Published: October 2019

AbstractThe identification of peptides and proteins from tandem mass spectra is a difficult task and multiple tools have been developed to aid this identification. We present a new method called quantum chemical mass spectrometry for materials science (QCMS2), which is based on quantum chemical calculations of bond orders, reaction, and transition‐state energies at the DFT/B3LYP/6‐311+G* level of theory. The method was used to describe the fragmentation pathways of five X‐His‐Ser tripeptides with X = Asn, Asp, Glu, Ser, and Trp, thereby focusing on the influence of the side chain and inter–side‐chain interactions on the fragmentation. The main features in the mass spectra of the five tripeptides were correctly reproduced, and a number of fragments were assigned to fragmentations involving the side chain and the influence of inter–side‐chain interactions. Product ion spectra were recorded to evaluate the capabilities and limitations of QCMS2 and a number of conventional tools.