bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annual incidence of cannabis-induced psychosis, other substance-induced psychoses and dually diagnosed schizophrenia and cannabis use disorder in Denmark from 1994 to 2016
Authors: Hjorthøj Carsten , Larsen Maria Oku , Starzer Marie Stefanie Kejser , Nordentoft Merete 
Published: December 2019

AbstractBackgroundWorldwide, cannabis is the most used illegal substance, and the use of cannabis has increased over the years. An increase in the level of tetrahydrocannabinol (THC) in cannabis has also been seen. It is currently unclear whether this has led to an increase in the incidence of cannabis-induced psychosis. We aimed to investigate (1) the development of incidence of cannabis-induced psychosis over time compared with other substance-induced psychoses and (2) the development of incident cases of cannabis-induced psychosis over time compared with dual diagnosis defined as schizophrenia and a cannabis use disorder.MethodData on psychiatric diagnoses were extracted from the Danish Psychiatric Central Research Register and summarized per year as both absolute incidence (number of cases) and incidence rates per 100 000 person years.ResultsThe incidence rate of cannabis-induced psychosis increased steadily from 2.8 per 100 000 person years in 2006 to 6.1 per 100 000 person years in 2016. There was a corresponding increase in dual diagnosis with schizophrenia and cannabis use disorder, but a decrease in alcohol-induced psychosis. The data showed no trend in the other substance-induced psychosis investigated in this thesis.ConclusionThe increase in cannabis-induced psychosis follows both the increase in the level of THC in cannabis, and the increase in cannabis use. The change in diagnostic practice does not appear to explain the increase in incidence of cannabis-induced psychosis.
Development and validation of the mental health professional culture inventory
Authors: Rapisarda F. , Corbière M. , Lesage A. D. , De Benedictis L. , Pelletier J. F. , Felx A. , Leblanc Y. , Vallarino M. , Miglioretti M. 
Published: December 2019

Abstract

Aims
No instrument has been developed to explicitly assess the professional culture of mental health workers interacting with severely mentally ill people in publicly or privately run mental health care services. Because of theoretical and methodological concerns, we designed a self-administered questionnaire to assess the professional culture of mental health services workers. The study aims to validate this tool, named the Mental Health Professional Culture Inventory (MHPCI). The MHPCI adopts the notion of ‘professional culture’ as a hybrid construct between the individual and the organisational level that could be directly associated with the professional practices of mental health workers.

Methods
The MHPCI takes into consideration a multidimensional definition of professional culture and a discrete number of psychometrically derived dimensions related to meaningful professional behaviour. The questionnaire was created and developed by a conjoint Italian-Canadian research team with the purpose of obtaining a fully cross-cultural questionnaire and was pretested in a pilot study. Subsequently, a validation survey was conducted in northern Italy and in Canada (Montreal area, Quebec). Data analysis was conducted in different steps designed to maximise the cross-cultural adaptation of the questionnaire through a recursive procedure consisting of performing a principal component analysis (PCA) on the Italian sample (N = 221) and then testing the resulting factorial model on the Canadian sample (N = 237). Reliability was also assessed with a test-retest design.

Results
Four dimensions emerged in the PCA and were verified in the confirmatory factor analysis: family involvement, users' sexuality, therapeutic framework and management of aggression risk. All the scales displayed good internal consistency and reliability.

Conclusions
This study suggests the MHPCI could be a valid and reliable instrument to measure the professional behaviour of mental health services workers. The content of the four scales is consistent with the literature on psychosocial rehabilitation, suggesting that the instrument could be used to evaluate staff behaviour regarding four crucial dimensions of mental health care.
Climate Forcing and Response to Greenhouse Gases, Aerosols, and Ozone in CESM1
Authors: Zhao Alcide , Stevenson David S. , Bollasina Massimo A. 
Published: December 2019

AbstractIt is crucial to reduce uncertainties in our understanding of the climate impacts of short‐lived climate forcers, in the context that their emissions/concentrations are anticipated to decrease significantly in the coming decades worldwide. Using the Community Earth System Model (CESM1), we performed time‐slice experiments to investigate the effective radiative forcing (ERF) and climate respons to 1970–2010 changes in well‐mixed greenhouse gases (GHGs), anthropogenic aerosols, and tropospheric and stratospheric ozone. Once the present‐day climate has fully responded to 1970–2010 changes in all forcings, both the global mean temperature and precipitation responses are twice as large as the transient ones, with wet regions getting wetter and dry regions drier. The temperature response per unit ERF for short‐lived species varies considerably across many factors including forcing agents and the magnitudes and locations of emission changes. This suggests that the ERF should be used carefully to interpret the climate impacts of short‐lived climate forcers. Changes in both the mean and the probability distribution of global mean daily precipitation are driven mainly by GHG increases. However, changes in the frequency distributions of regional mean daily precipitation are more strongly influenced by changes in aerosols, rather than GHGs. This is particularly true over Asia and Europe where aerosol changes have significant impacts on the frequency of heavy‐to‐extreme precipitation. Our results may help guide more reliable near‐future climate projections and allow us to manage climate risks more effectively.
Seasonal evolution of active layer thaw depth and hillslope‐stream connectivity in a permafrost watershed
Authors: Chiasson‐Poirier G. , Franssen J. , Lafrenière M. J. , Fortier D. , Lamoureux S. F. 
Published: December 2019

AbstractTo advance our understanding of permafrost hillslope drainage dynamics and its influence on streamflow hydrochemistry, we instrumented a hillslope‐stream sequence located in the headwaters of the Niaqunguk River watershed, Nunavut, Canada (63°N, 68°W). We combined high spatial resolution field measurements of water and frost tables across the hillslope, with semiweekly measurements of groundwater and streamflow chemistry to track the evolution of streamflow chemistry during active layer thaw. Interestingly, localized differential thaw patterns emerged under near saturation conditions across the instrumented hillslope, the result of a low‐frequency high‐magnitude summer rainfall event. Hillslope structure and uneven active layer thaw created two distinct fill‐and‐spill domains. A subsurface domain defined by frost table microtopography and a surface domain defined by surface topography. We observed a seasonal shift in streamflow chemistry with an increased influence of water flowing through the underlying mineral soils as the active layer thawed. As thaw progressed streamflow chemistry began to match that of the riparian groundwater, which was a mixture of hillslope surface and subsurface water. Hillslope‐stream surface connections were sporadic and occurred when rainfall and saturation conditions across the lower portion of the hillslope were sufficient for water to spill out of midslope surface depressions and across a saturated riparian zone and into the stream. This research shows how hillslope structure and thaw processes influence hillslope‐stream connectivity in permafrost terrain.
Evaluation of a national lung cancer symptom awareness campaign in Wales
Authors: McCutchan Grace , Smits Stephanie , Ironmonger Lucy , Slyne Ciarán , Boughey Amanda , Moffat Jodie , Thomas Rebecca , Huws Dyfed Wyn , Brain Kate 
Published: December 2019

Abstract
Background
Lung cancer is the leading cause of cancer mortality in Wales. We conducted a before- and after- study to evaluate the impact of a four-week mass-media campaign on awareness, presentation behaviour and lung cancer outcomes.

Methods
Population-representative samples were surveyed for cough symptom recall/recognition and worry about wasting doctors’ time pre-campaign (June 2016; n = 1001) and post-campaign (September 2016; n = 1013). GP cough symptom visits, urgent suspected cancer (USC) referrals, GP-ordered radiology, new lung cancer diagnoses and stage at diagnosis were compared using routine data during the campaign (July–August 2016) and corresponding control (July–August 2015) periods.

Results
Increased cough symptom recall (p < 0.001), recognition (p < 0.001) and decreased worry (p < 0.001) were observed. GP visits for cough increased by 29% in the target 50+ age-group during the campaign (p < 0.001) and GP-ordered chest X-rays increased by 23% (p < 0.001). There was no statistically significant change in USC referrals (p = 0.82), new (p = 0.70) or early stage (p = 0.27) diagnoses, or in routes to diagnosis.

Conclusions
Symptom awareness, presentation and GP-ordered chest X-rays increased during the campaign but did not translate into increased USC referrals or clinical outcomes changes. Short campaign duration and follow-up, and the small number of new lung cancer cases observed may have hampered detection effects.
SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma
Authors: Hou Yuchen , Wang Ziming , Huang Shanzhou , Sun Chengjun , Zhao Jingya , Shi Jiayu , Li Zhongqiu , Wang Zekang , He Xiaoshun , Tam Nga Lei , Wu Linwei 
Published: December 2019

AbstractSpindle and kinetochore-related complex subunit 3 (SKA3) is a component of the spindle and kinetochore-related complexes and is essential for accurate timing of late mitosis. However, the relationship between SKA3 and hepatocellular carcinoma (HCC) has not yet been fully elucidated. Gene expression omnibus (GEO) (GSE62232, GSE45436, GSE6764, and GSE36376) and The Cancer Atlas (TCGA) datasets were analyzed to identify differential expression genes. Cell proliferation ability was analyzed using Cell Counting Kit-8 (CCK8) assay and plate clone formation assay, while scratch wound healing assay and transwell assay were used to analyze cell invasion. The role of SKA3 in vivo was explored using subcutaneous xenotransplantation model and lung metastasis model. Bioinformatics analysis found that hepatocellular carcinoma patients with high levels of expression of SKA3 have a poor prognosis. Similarly, immunohistochemical staining of 236 samples of tumors also found higher SKA3 expression in them, than in adjacent normal liver tissues. Significant levels of inhibition of in vivo and in vitro tumor proliferation and invasion result from the downregulation of SKA3. Mechanistically, SKA3 was found to affect tumor progression through the cell cycle and P53 signaling pathway as shown by the gene enrichment analysis (GSEA). G2/M phase arrest and severe apoptosis was also found to result from SKA3 knockdown, as shown by the inhibition of CDK2/p53 phosphorylation together with downregulation of BAX/Bcl-2 expression in HCC cells. Overall, these findings uncover the role of SKA3 in regulating the apoptosis and proliferation of hepatocellular carcinoma cells. This study was able to uncover new information on the tumorigenesis mechanism in hepatocellular carcinoma.
SweHLA: the high confidence HLA typing bio-resource drawn from 1000 Swedish genomes
Authors: Nordin Jessika , Ameur Adam , Lindblad-Toh Kerstin , Gyllensten Ulf , Meadows Jennifer R. S. 
Published: December 2019

AbstractThere is a need to accurately call human leukocyte antigen (HLA) genes from existing short-read sequencing data, however there is no single solution that matches the gold standard of Sanger sequenced lab typing. Here we aimed to combine results from available software programs, minimizing the biases of applied algorithm and HLA reference. The result is a robust HLA population resource for the published 1000 Swedish genomes, and a framework for future HLA interrogation. HLA 2nd-field alleles were called using four imputation and inference methods for the classical eight genes (class I: HLA-A, HLA-B, HLA-C; class II: HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1). A high confidence population set (SweHLA) was determined using an n−1 concordance rule for class I (four software) and class II (three software) alleles. Results were compared across populations and individual programs benchmarked to SweHLA. Per gene, 875 to 988 of the 1000 samples were genotyped in SweHLA; 920 samples had at least seven loci called. While a small fraction of reference alleles were common to all software (class I = 1.9% and class II = 4.1%), this did not affect the overall call rate. Gene-level concordance was high compared to European populations (>0.83%), with COX and PGF the dominant SweHLA haplotypes. We noted that 15/18 discordant alleles (delta allele frequency >2) were previously reported as disease-associated. These differences could in part explain across-study genetic replication failures, reinforcing the need to use multiple software solutions. SweHLA demonstrates a way to use existing NGS data to generate a population resource agnostic to individual HLA software biases.
Electrical control of spins and giant g-factors in ring-like coupled quantum dots
Authors: Potts H. , Chen I.–J. , Tsintzis A. , Nilsson M. , Lehmann S. , Dick K. A. , Leijnse M. , Thelander C. 
Published: December 2019

AbstractEmerging theoretical concepts for quantum technologies have driven a continuous search for structures where a quantum state, such as spin, can be manipulated efficiently. Central to many concepts is the ability to control a system by electric and magnetic fields, relying on strong spin-orbit interaction and a large g-factor. Here, we present a mechanism for spin and orbital manipulation using small electric and magnetic fields. By hybridizing specific quantum dot states at two points inside InAs nanowires, nearly perfect quantum rings form. Large and highly anisotropic effective g-factors are observed, explained by a strong orbital contribution. Importantly, we find that the orbital contributions can be efficiently quenched by simply detuning the individual quantum dot levels with an electric field. In this way, we demonstrate not only control of the effective g-factor from 80 to almost 0 for the same charge state, but also electrostatic change of the ground state spin.
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
Authors: Yu Jin-mei , Sun Wei , Wang Zhen-he , Liang Xiao , Hua Fang , Li Ke , Lv Xiao-xi , Zhang Xiao-wei , Liu Yu-ying , Yu Jiao-jiao , Liu Shan-shan , Shang Shuang , Wang Feng , Yang Zhao-na , Zhao Chen-xi , Hou Xue-ying , Li Ping-ping , Huang Bo , Cui Bing , Hu Zhuo-Wei 
Published: December 2019

AbstractThe existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and therapy resistance. Here we report that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progression. Elevated TRIB3 expression supports BCSCs by interacting with AKT to interfere with the FOXO1-AKT interaction and suppress FOXO1 phosphorylation, ubiquitination, and degradation by E3 ligases SKP2 and NEDD4L. The accumulated FOXO1 promotes transcriptional expression of SOX2, a transcriptional factor for cancer stemness, which in turn, activates FOXO1 transcription and forms a positive regulatory loop. Disturbing the TRIB3-AKT interaction suppresses BCSCs by accelerating FOXO1 degradation and reducing SOX2 expression in mouse models of breast cancer. Our study provides insights into breast cancer development and confers a potential therapeutic strategy against TRIB3-overexpressed breast cancer.
Robust edge photocurrent response on layered type II Weyl semimetal WTe2
Authors: Wang Qinsheng , Zheng Jingchuan , He Yuan , Cao Jin , Liu Xin , Wang Maoyuan , Ma Junchao , Lai Jiawei , Lu Hong , Jia Shuang , Yan Dayu , Shi Youguo , Duan Junxi , Han Junfeng , Xiao Wende , Chen Jian-Hao , Sun Kai , Yao Yugui , Sun Dong 
Published: December 2019

AbstractPhotosensing and energy harvesting based on exotic properties of quantum materials and new operation principles have great potential to break the fundamental performance limit of conventional photodetectors and solar cells. Weyl semimetals have demonstrated novel optoelectronic properties that promise potential applications in photodetection and energy harvesting arising from their gapless linear dispersion and Berry field enhanced nonlinear optical effect at the vicinity of Weyl nodes. In this work, we demonstrate robust photocurrent generation at the edge of Td-WTe2, a type-II Weyl semimetal, due to crystalline-symmetry breaking along certain crystal fracture directions and possibly enhanced by robust fermi-arc type surface states. This edge response is highly generic and arises universally in a wide class of quantum materials with similar crystal symmetries. The robust and generic edge current response provides a charge separation mechanism for photosensing and energy harvesting over broad wavelength range.
The Impact of Rate Formulations on Stochastic Molecular Motor Dynamics
Authors: Blackwell R. , Jung D. , Bukenberger M. , Smith A.-S. 
Published: December 2019

AbstractCells are complex structures which require considerable amounts of organization via transport of large intracellular cargo. While passive diffusion is often sufficiently fast for the transport of smaller cargo, active transport is necessary to organize large structures on the short timescales necessary for biological function. The main mechanism of this transport is by cargo attachment to motors which walk in a directed fashion along intracellular filaments. There are a number of models which seek to describe the motion of motors with attached cargo, from detailed microscopic to coarse phenomenological descriptions. We focus on the intermediate-detailed discrete stochastic hopping models, and explore how cargo transport changes depending on the number of motors, motor interaction, system constraints and rate formulations, which are derived from common thermodynamic assumptions. We find that, despite obeying the same detailed balance constraint, the choice of rate formulation considerably affects the characteristics of the overall motion of the system, with one rate formulation exhibiting novel behavior of loaded motor groups moving faster than a single unloaded motor.
Rapid identification of respiratory bacterial pathogens from bronchoalveolar lavage fluid in cattle by MALDI-TOF MS
Authors: Van Driessche Laura , Bokma Jade , Deprez Piet , Haesebrouck Freddy , Boyen Filip , Pardon Bart 
Published: December 2019

AbstractRespiratory tract infections are a major health problem and indication for antimicrobial use in cattle and in humans. Currently, most antimicrobial treatments are initiated without microbiological results, holding the risk of inappropriate first intention treatment. The main reason for this empirical treatment is the long turnaround time between sampling and availability of identification and susceptibility results. Therefore the objective of the present study was to develop a rapid identification procedure for pathogenic respiratory bacteria in bronchoalveolar lavage fluid (BALf) samples from cattle by MALDI-TOF MS, omitting the cultivation step on agar plates to reduce the turnaround time between sampling and identification of pathogens. The effects of two different liquid growth media and various concentrations of bacitracin were determined to allow optimal growth of Pasteurellaceae and minimise contamination. The best procedure was validated on 100 clinical BALf samples from cattle with conventional bacterial culture as reference test. A correct identification was obtained in 73% of the samples, with 59.1% sensitivity (Se) (47.2–71.0%) and 100% specificity (Sp) (100–100%) after only 6 hours of incubation. For pure and dominant culture samples, the procedure was able to correctly identify 79.2% of the pathogens, with a sensitivity (Se) of 60.5% (45.0–76.1%) and specificity (Sp) of 100% (100–100%). In mixed culture samples, containing ≥2 clinically relevant pathogens, one pathogen could be correctly identified in 57% of the samples with 57.1% Se (38.8–75.5%) and 100% Sp (100–100%). In conclusion, MALDI-TOF MS is a promising tool for rapid pathogen identification in BALf. This new technique drastically reduces turnaround time and may be a valuable decision support tool to rationalize antimicrobial use.
Assessment of emotional predisposition in dogs using PANAS (Positive and Negative Activation Scale) and associated relationships in a sample of dogs from Brazil
Authors: Savalli Carine , Albuquerque Natalia , Vasconcellos Angélica S. , Ramos Daniela , de Mello Fernanda T. , Mills Daniel S. 
Published: December 2019

AbstractThe English version of the Positive and Negative Activation Scale (PANAS) is a useful tool for the assessment of dog temperament, helping to identify highly sensitive individuals that could be at risk of developing fears, phobias and anxiety problems, and potentially depressive states. This study evaluated the association between dogs’ and owners’ characteristics and dog temperament in Brazil. To accomplish this, we adapted and validated a Portuguese language version of PANAS for dogs. Data from 1744 owner-dog dyads were analysed and a two-factor structure similar to the original PANAS was revealed that met the requirements for validity and internal consistency. We found that dogs owned by women, neutered dogs and those who live in single-dog households show higher negative activation. Moreover, the older the owner, the less the negative activation for dogs that are bought. We also found that the older the dog, the less the positive activation, but this score is higher in dogs that sleep inside the house. Interestingly, mixed-breed dogs scored higher for both negative and positive emotional activation compared to purebreds. These findings alongside the particular profile of dogs in Brazil, including its large population of mixed-breed, emphasise the value of cross-cultural investigations in order to develop a full understanding of dog behaviour.
Growth estimates of Caribbean reef sponges on a shipwreck using 3D photogrammetry
Authors: Olinger Lauren K. , Scott Alexander R. , McMurray Steven E. , Pawlik Joseph R. 
Published: December 2019

AbstractThe growth rates and ages of many benthic marine organisms are poorly understood, complicating our understanding of ecosystem change. This is particularly true for sponges, which are morphologically diverse and lack indicators of annual growth. In this study, we used emerging technologies to measure volume, surface area, and approximate age of 16 sponge species on the Tibbetts shipwreck off Cayman Brac, Caribbean Sea. Photogrammetry was used to determine the volume of individual sponges on the wreck surface, and a time series of YouTube videos was amassed in order to approximate the greatest possible age of the sponges as 8.74 y. Applying the volume measurements to an existing growth equation for the Caribbean sponge Aiolochroia crassa yielded age estimates of 5.2–10.4 y for the largest individuals of the 16 species. Specific growth rates were then calculated for 7 species from the Tibbetts and 8 species from a second shipwreck (Spiegel Grove, Key Largo, FL). Subsequent growth forecasts from these 15 species corroborate a resource trade-off between growth and the production of chemical defenses. Shipwrecks and other anthropogenic structures can be an important source of demographic information for benthic organisms, provided that certain assumptions about their provenance and history can be met.