bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the vulnerability of a partly covered karst feature in Veszprém, Hungary
Authors: Trájer Attila J. , Mlinárik Lilla , Hammer Tamás , Földényi Rita , Somlai János , Bede-Fazekas Ákos 
Published: April 2020

AbstractKarst aquifers represent the most important renewable sources of drinking water. Because anthropogenic influences threaten the integrity of karst aquifers, it is important to determine the soil erosion and karst denudation rates. In order to study the complex signs of degradation processes of the karst, a paleodoline (paleo-polje) was selected near to the county seat Veszprém, Hungary. It was found that gamma radiation measurements can be a useful tool to detect the level of soil erosion since the low gamma radiation indicates the surface proximity of the carbonate bedrock. The level of gamma radiation also predicts the potential agricultural usability of a site. Both the patterns of contamination and the erosion attack zone are strongly defined by the relief. The gullies and the deepest parts of the karstic landscape are the traps of organic materials and pollutants. The amounts of 40K and its decay products originate from the covering sediment and negatively correlate with the soil depth. In the case of covered karsts, the measuring of the concentration of radionuclides and field gamma-ray dose measurement together can characterize the general horizontal and vertical trends of soil erosion, the potential land use, and the vegetation.
Merging the arts and sciences for collaborative sustainability action: a methodological framework
Authors: Trott Carlie D. , Even Trevor L. , Frame Susan M. 
Published: April 2020

AbstractThis manuscript explores the possibilities and challenges of art–science integration in facilitating collaborative sustainability action in local settings. To date, much sustainability education is prescriptive, rather than participatory, and most integrated art–science programming aims for content learning, rather than societal change. What this means is that learners are more often taught “what is” than invited to imagine “what if?” In order to envision and enact sustainable alternatives, there is a need for methods that allow community members, especially young people, to critically engage with the present, imagine a better future, and collaboratively act for sustainability today. This manuscript introduces a methodological framework that integrates the arts and sciences to facilitate: (1) transdisciplinary learning, focusing on local sustainability challenges; (2) participatory process, bringing experience-based knowledge into conversation with research-based knowledge; and (3) collaborative sustainability action, inviting community members to envision and enact sustainable alternatives where they live. The transformative potential of this framework is examined through international case studies from countries representing the richest and poorest in the Western hemisphere: a multi-site research study and after-school program for climate change education and action in collaboration with children in the Western US; and a multi-cycle research study and community arts center course for environmental photography and youth-led water advocacy in Southern Haiti. Despite many shared characteristics, case studies diverge in important ways relative to the sustainability challenges they sought to address, the specific context in which activities took place, and the manner in which art–science integration was practiced. Across cases, however, art–science integration facilitated participants’ learning, connection, and action for sustainability. Framed by the shared aims of transdisciplinary approaches, this manuscript discusses methodological hurdles and practical lessons learned in art–science integration across settings as well as the transformative capacity of alternative pedagogical and research practices in building a sustainable future.
Analysing trade-offs and synergies between SDGs for urban development, food security and poverty alleviation in rapidly changing peri-urban areas: a tool to support inclusive urban planning
Authors: Dolley Jonathan , Marshall Fiona , Butcher Bradley , Reffin Jeremy , Robinson James Alexander , Eray Baris , Quadrianto Novi 
Published: April 2020

AbstractTransitional peri-urban contexts are frontiers for sustainable development where land-use change involves negotiation and contestation between diverse interest groups. Multiple, complex trade-offs between outcomes emerge which have both negative and positive impacts on progress towards achieving Sustainable Development Goals (SDGs). These trade-offs are often overlooked in policy and planning processes which depend on top-down expert perspectives and rely on course grain aggregate data which does not reflect complex peri-urban dynamics or the rapid pace of change. Tools are required to address this gap, integrate data from diverse perspectives and inform more inclusive planning processes. In this paper, we draw on a reinterpretation of empirical data concerned with land-use change and multiple dimensions of food security from the city of Wuhan in China to illustrate some of the complex trade-offs between SDG goals that tend to be overlooked with current planning approaches. We then describe the development of an interactive web-based tool that implements deep learning methods for fine-grained land-use classification of high-resolution remote sensing imagery and integrates this with a flexible method for rapid trade-off analysis of land-use change scenarios. The development and potential use of the tool are illustrated using data from the Wuhan case study example. This tool has the potential to support participatory planning processes by providing a platform for multiple stakeholders to explore the implications of planning decisions and land-use policies. Used alongside other planning, engagement and ecosystem service mapping tools it can help to reveal invisible trade-offs and foreground the perspectives of diverse stakeholders. This is vital for building approaches which recognise how trade-offs between the achievement of SDGs can be influenced by development interventions.
MicroRNA Let-7b-5p Induces Electroacupuncture Tolerance by Downregulating the MKP-1 Gene in Rats Subjected to CFA-induced Inflammatory Nociception
Authors: Zhang Qiulin , Abouelfetouh Mahmoud M. , Chen Shuhuai , Li Meng , Ding Mingxing , Ding Yi 
Published: April 2020

AbstractElectroacupuncture (EA) treatment has proved to significantly decrease nociception in inflammatory nociception model by suppressing the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK). However, repeated EA treatment results in gradual attenuation of its analgesic effects, which was defined as “EA tolerance.” Recent studies have shown that let-7b-5p microRNA (miRNA) contributes to the EA tolerance. The present study aimed to explore the function of let-7b-5p in p38MAPK pathway and the development of EA tolerance in the inflammatory nociception. Dual luciferase reporter gene experiments were used in cortical neurons to determine the target gene locus of let-7b-5p. The threshold of nociception was assessed by tail flick latency (TFL) and paw withdrawal threshold (PWT). Western blots were used to measure the expression of mitogen-activated protein kinase phosphatase 1 (MKP-1) and phosphorylation level of p38MAPK after intracerebroventricular (ICV) injections of let-7b-5p agomir, antagomir, and controls. In vitro dual luciferase experiments demonstrated that the MKP-1-3′ untranslated region (UTR) is a target of let-7b-5p. In vivo experiment, rat with repeated EA treatment exhibits gradual decrease in TFL and PWT, which showed formation of EA tolerance. This trend was delayed after IVC injection of let-7b-5p antagomir and facilitated after IVC injection of let-7b-5p agomir. The protein levels of MKP-1 in the EA+let-7b-5p antagomir group were significantly higher than in the EA + let-7b-5p agomir group. However, P-p38MAPK in the EA+let-7b-5p antagomir group was significantly lower than in the EA+let-7b-5p agomir group. By upregulating the p38MAPK pathway through the inactivation of the MKP-1 gene, let-7b-5p contributes to EA tolerance in complete Freund’s adjuvant (CFA)-induced inflammatory nociception rats. Our work revealed the mechanism of EA tolerance and indicated that let-7b-5p could be targeted to improve the long-term effects of EA.
Care Leaver aus Pflegefamilien
Authors: Ehlke Carolin 
Published: April 2020

ZusammenfassungSeit fast zehn Jahren wird auch in Deutschland intensiver zum Thema „Leaving Care“ und „Care Leaver“ geforscht. Trotz dessen haben sich bislang nur sehr wenige Studien mit dem Übergang von jungen Menschen aus Pflegefamilien ins Erwachsenenleben beschäftigt. Zudem wurden nur selten Care Leaver selbst zu ihren Übergangserfahrungen befragt. Daher ist das Wissen darum, wie junge Menschen aus Pflegefamilien den Prozess des Leaving Care aus ihrer Sicht erleben, noch rar. Die Studie „Care Leaver aus Pflegefamilien“ der Autorin hat sich dieser Forschungslücken angenommen und u. a. untersucht, wie und von wem die jungen Menschen während des Übergangs unterstützt wurden. Im Fokus des Beitrags stehen somit soziale Beziehungen sowie die darin deutlich werdende Konstruktion von (familiären) Zugehörigkeiten. Zusammenfassend wird vorgeschlagen, unter dem Konzept eines „doing relationships“ viel stärker die unterschiedlichen Beziehungen von Care Leavern im Hilfe- bzw. Übergangsprozess in den Blick zu nehmen.
1H, 13C, and 15N Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein
Authors: Lang Andras , Kumar Amit , Jirschitzka Jan , Bordusa Frank , Ohlenschläger Oliver , Wiedemann Christoph 
Published: April 2020

AbstractThe brain and acute leukemia cytoplasmic (BAALC; UniProt entry Q8WXS3) is a 180-residue-long human protein having six known isoforms. BAALC is expressed in either hematopoietic or neuroectodermal cells and its specific function is still to be revealed. However, as a presumably membrane-anchored protein at the cytoplasmic side it is speculated that BAALC exerts its function at the postsynaptic densities of certain neurons and might play a role in developing cytogenetically normal acute myeloid leukemia (CN-AML) when it is highly overexpressed by myeloid or lymphoid progenitor cells. In order to better understand the physiological role of BAALC and to provide the basis for a further molecular characterization of BAALC, we report here the 1H, 13C, and 15N resonance assignments for the backbone nuclei of its longest hematopoietic isoform (isoform 1). In addition, we present a 1HN and 15NH chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the 1H and 15N chemical shifts.
Microglia-Derived NLRP3 Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats
Authors: Hu Li , Zhang Shutian , Ooi Kokwin , Wu Xuehai , Wu Jiaxiang , Cai Jian , Sun Yinggang , Wang Jijiang , Zhu Danian , Chen Fuxue , Xia Chunmei 
Published: April 2020

AbstractIncreased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla (RVLM) have been implicated in stress-induced hypertension (SIH). Prorenin, a member of the brain renin-angiotensin system (RAS), can directly activate microglia. The present study aimed to investigate the effects of prorenin on microglial activation in the RVLM of SIH rats. Rats were subjected to intermittent electric foot-shocks plus noise, this stress was administered for 2 h twice daily for 15 consecutive days, and mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) were monitored. The results showed that MAP and RSNA were augmented, and this paralleled increased pro-inflammatory phenotype (M1) switching. Prorenin and its receptor (PRR) expression and the NLR family pyrin domain containing 3 (NLRP3) activation were increased in RVLM of SIH rats. In addition, PLX5622 (a microglial depletion agent), MCC950 (a NLRP3 inhibitor), and/or PRO20 (a (Pro)renin receptor antagonist) had antihypertensive effects in the rats. The NLRP3 expression in the RVLM was decreased in SIH rats treated with PLX5622. Mito-tracker staining showed translocation of NLRP3 from mitochondria to the cytoplasm in prorenin-stimulated microglia. Prorenin increased the ROS-triggering M1 phenotype-switching and NLRP3 activation, while MCC950 decreased the M1 polarization. In conclusion, upregulated prorenin in the RVLM may be involved in the pathogenesis of SIH, mediated by activation of the microglia-derived NLRP3 inflammasome. The link between prorenin and NLRP3 in microglia provides insights for the treatment of stress-related hypertension.
Hydrogen and Carbon Nanotubes from Pyrolysis-Catalysis of Waste Plastics: A Review
Authors: Williams Paul T. 
Published: April 2020

AbstractMore than 27 million tonnes of waste plastics are generated in Europe each year representing a considerable potential resource. There has been extensive research into the production of liquid fuels and aromatic chemicals from pyrolysis-catalysis of waste plastics. However, there is less work on the production of hydrogen from waste plastics via pyrolysis coupled with catalytic steam reforming. In this paper, the different reactor designs used for hydrogen production from waste plastics are considered and the influence of different catalysts and process parameters on the yield of hydrogen from different types of waste plastics are reviewed. Waste plastics have also been investigated as a source of hydrocarbons for the generation of carbon nanotubes via the chemical vapour deposition route. The influences on the yield and quality of carbon nanotubes derived from waste plastics are reviewed in relation to the reactor designs used for production, catalyst type used for carbon nanotube growth and the influence of operational parameters.
Graphic Abstract
Kinship Without Words
Authors: Layton Robert 
Published: April 2020

AbstractThis article seeks to identify at what point in hominid evolution language would have become adaptive. It starts by recalling the distinction between kin-selected altruism and reciprocal altruism, noting that the former is characteristic of social insects while the latter is found among some species of social mammal. Reciprocal altruism depends on the exchange of information assuring partners of the other’s continued friendly intent, as in the iterated prisoner’s dilemma. The article focuses on species that practice “fission–fusion”: social behaviour, where the alternation between larger and smaller parties creates greater uncertainty as to individuals’ continued commitment to reciprocity. The greatest uncertainty arises in “atomistic” fission–fusion, where individuals leave and join foraging groups independently. Chimpanzees, bonobos, and human hunter–gatherers practice this type of social behaviour. There is less uncertainty where the smaller social unit is an extended family, as among vampire bats, chacma baboons, and savanna elephants. A comparison of the repertoire of calls and gestures among these species indicates that chimpanzees and bonobos have the largest repertoires. I then point out that, thanks to the higher proportion of meat in the diet, hunter–gatherers must live in far more dispersed communities than chimpanzees or bonobos, yet they practice more complex patterns of cooperation and reciprocity. This, I argue, created a social environment in which language became particularly adaptive.Homo heidelbergensisis identified as the key species in which language could have originated, during the transition between the Lower and Middle Paleolithic.
A review of recent advances in tribology
Authors: Meng Yonggang , Xu Jun , Jin Zhongmin , Prakash Braham , Hu Yuanzhong 
Published: April 2020

AbstractThe reach of tribology has expanded in diverse fields and tribology related research activities have seen immense growth during the last decade. This review takes stock of the recent advances in research pertaining to different aspects of tribology within the last 2 to 3 years. Different aspects of tribology that have been reviewed including lubrication, wear and surface engineering, biotribology, high temperature tribology, and computational tribology. This review attempts to highlight recent research and also presents future outlook pertaining to these aspects. It may however be noted that there are limitations of this review. One of the most important of these is that tribology being a highly multidisciplinary field, the research results are widely spread across various disciplines and there can be omissions because of this. Secondly, the topics dealt with in the field of tribology include only some of the salient topics (such as lubrication, wear, surface engineering, biotribology, high temperature tribology, and computational tribology) but there are many more aspects of tribology that have not been covered in this review. Despite these limitations it is hoped that such a review will bring the most recent salient research in focus and will be beneficial for the growing community of tribology researchers.
Datenbrillen am Arbeitsplatz
Authors: Holz A. , Herold R. , Friemert D. , Hartmann U. , Harth V. , Terschüren C. 
Published: April 2020

ZusammenfassungDer Artikel gibt eine Übersicht über den aktuellen Forschungsstand zum Einsatz von Datenbrillen an industriellen Arbeitsplätzen. Datenbrillen präsentieren Informationen und Instruktionen zu Tätigkeiten und Arbeitsschritten in einem in die Brille integrierten Display unmittelbar vor dem Auge. Laptops und mobile Handscanner, die in den Händen gehalten werden müssen, um Informationen zu lesen bzw. zu erfassen, sollen dadurch abgelöst werden. In der Branche der Warenlogistik und Kommissionierung besteht ein großes Interesse daran, die Beschäftigten mit Datenbrillen auszustatten, sodass sie beide Hände für die manuellen Kommissionierungstätigkeiten und den Transport in den Logistikzentren frei haben. Es stellt sich die Frage, welche veränderten Belastungen und Beanspruchungen die Positionierung des Displays mit den für die Tätigkeit benötigten Angaben als Text oder Grafik direkt vor dem Auge für die Beschäftigten bedeutet. Zum gegenwärtigen Zeitpunkt liegen überwiegend Ergebnisse aus Pilotstudien oder aus experimentellen Studien vor, bei denen Probanden an nachgebauten Laborarbeitsplätzen unter standardisierten Bedingungen Datenbrillen genutzt haben. Dieser Artikel ist das Ergebnis einer umfangreichen Literaturrecherche, fasst die bisherigen Ergebnisse zu möglichen Auswirkungen von Datenbrillen auf die Gesundheit der Augen zusammen und beinhaltet auch die Diskussion über psychische Belastungen und Beanspruchungen, die bei intensiver Nutzung von Datenbrillen auftreten können.
What to do when patients and physicians disagree? Qualitative research among physicians with different working experiences
Authors: van Bruchem-Visser Rozemarijn Lidewij , de Beaufort Inez Duconia , Mattace-Raso Francesco Umberto Salvatore , Kuipers Ernst Johan 
Published: April 2020

Abstract
Purpose
Impasses between patients, relatives and physicians occur frequently. With the growing attention for shared decision making, it is valuable to know how impasses arise. To understand the challenges experienced by physicians when their opinion on medical decisions differ from those of patients or relatives.

Methods
Fifteen physicians with different working experiences, from five medical specialties were interviewed using a narrative approach. Interviews were based on two patient stories provided by the physician. First of a patient (or relative) who did not want to adhere to a treatment the physician deemed necessary, and the second of a patient (or relative) who requested a treatment the physician felt was unnecessary. Data were analyzed using a bottom-up approach, with identification of five themes (autonomy of the patient, communication, emotions, circumstances and metaphors). Twenty subthemes were formed.

Results
693 references were made. Six major nodes were identified: frustration experienced by the physician, role of the relatives, agreement, cultural/religious aspects, comprehension by the patient of the situation and the existence of an established relationship between patient and physician.

Conclusions
Physicians felt uncomfortable when there was disagreement between themselves and patients or relatives. Frustration was felt when relatives spoke on behalf of the patient, while there was no evidence the desired decision was ever expressed by the patient. A disagreement with a patient was described as being less frustrating, when the patient was able to explain the reasons for making a decision. Differences in background, especially religious, were often mentioned as complicating communication.
Soup, Harmony, and Disagreement
Authors: WONG DAVID B. 
Published: April 2020

AbstractIs the ancient Confucian ideal of he 和, ‘harmony,’ a viable ideal in pluralistic societies composed of people and groups who subscribe to different ideals of the good and moral life? Is harmony compatible with accepting, even encouraging, difference and the freedom to think differently? I start with seminal characterizations of harmony in Confucian texts and then aim to chart ways harmony and freedom can be compatible and even mutually supportive while recognizing the constant possibility of conflict between them. I shall point out how the Confucian notion of harmony resonates with the Indian King Asoka's project of promoting religious pluralism. Along the way, I will make some comments of a ‘meta’ nature about the kind of interpretation I am offering of harmony in the Confucian texts and the use to which I am putting this interpretation by setting it in the context of societies that in important respects are quite different from the ones from which concepts of harmony originally emerged.
Who Supports Citizens Selected by Lot to be the Main Policymakers? A Study of French Citizens
Authors: Bedock Camille , Pilet Jean-Benoit 
Published: April 2020

AbstractDespite their multiplication over the last 15 years, studies on the support for assemblies composed of citizens selected by lot are rare and the few that exist analyse citizens’ attitudes towards such mini-publics as consultative bodies associated with traditional representative institutions. In this article, we examine support for citizens selected by lot as new policymakers who take the most important political decisions instead of political representatives. We contrast support for this radical democratic innovation with support for two other reforms that increase citizen participation: generic support for a greater involvement of citizens in policymaking, and specific support for citizen-initiated referendums. The goal is to understand whether the drivers of support for citizens selected by lot overlap or differ from the drivers of support for other forms of citizen participation. We rely upon data from the 2017 French Election Study.