bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacogenetic effects of angiotensin-converting enzyme inhibitors over age-related urea and creatinine variations in patients with dementia due to Alzheimer disease
Authors: Oliveira Fabricio Ferreira de , Berretta Juliana Marília , Chen Elizabeth Suchi , Smith Marilia Cardoso , Bertolucci Paulo Henrique Ferreira 
Published: November 2019

Background:Renal function declines according to age and vascular risk factors, whereas few data are available regarding genetically-mediated effects of anti-hypertensives over renal function.Objective:To estimate urea and creatinine variations in dementia due to Alzheimer disease (AD) by way of a pharmacogenetic analysis of the anti-hypertensive effects of angiotensin-converting enzyme inhibitors (ACEis).Methods:Consecutive outpatients older than 60 years-old with AD and no history of kidney transplant or dialytic therapy were recruited for prospective correlations regarding variations in fasting blood levels of urea and creatinine in one year, considering ACE genotypes of rs1800764 and rs4291 and their respective haplotypes, and treatment with ACEis along with blood pressure variations.Results:For 190 patients, 152 had arterial hypertension, and 122 used ACEis. Minor allele frequencies were 0.492 for rs1800764-C and 0.337 for rs4291-T, both in Hardy-Weinberg equilibrium. There were no overall significant yearly variations in levels of urea and creatinine, but their concurrent variations were positively correlated (ρ <0.0001). Each A allele of rs4291 led to an yearly urea increase of 3.074 mg/dL, and an yearly creatinine increase of 0.044 mg/dL, while the use of ACEis was protective regarding creatinine variations. The use of ACEis was also protective for carriers of rs1800764-CT/rs4291-AA, while carriers of rs1800764-CT/rs4291-AT had steeper reductions in creatinine levels, particularly when they were treated with ACEis.Conclusions:Effects of ACEis over creatinine variations are genetically mediated and independent of blood pressure variations in older people with AD.
Coinfección de tuberculosis y candidiasis pulmonar en paciente previamente sana
Authors: Fontalvo Dilia Mildret , Jiménez Borré Gustavo , Gómez Camargo Doris , Chalavé Jiménez Neylor , Bellido Rodríguez Javier , Cuadrado Cano Bernarda , Navarro Gómez Shirley 
Published: November 2019

Antecedentes:La coexistencia entre los hongos patógenos y la tuberculosis pulmonar es una condición clínica que se produce generalmente en pacientes inmunosuprimidos, sin embargo, los pacientes inmunocompetentes puede tener esta condición con menor frecuencia.Objetivo:Presentamos el caso de un paciente inmunocompetente con diagnóstico de una coinfección de tuberculosis Mycobacterium tuberculosis y Candida albicans.Caso clínico:Paciente femenina de 22 años con cuadro abrupto de tos, fiebre y hemoptisis sin antecedentes de enfermedad.Hallazgos clínicos y métodos diagnósticos:Al examen respiratorio se halló disminución del murmullo vesicular en la región apical y estertores crepitantes basales en el pulmón izquierdo. Se realizó estudios microbiológicos de muestras tomadas por expectoración y por fibrobroncoscopia en el que se incluyó la tinción de Ziehl-Neelsen, cultivo para micobacteria y hongos en medio Agar Dextrosa Sabouraud y filamentización en suero obteniéndose positividad para Mycobacterium tuberculosis y Candida albicans.Tratamiento y resultado:Se le realizó manejo con antifímicos de primera categoría y antimicóticos con buena respuesta clínica.Relevancia clínica:La coinfección fúngica y tuberculosis pulmonar no es frecuente en pacientes inmunocompetentes, debe sospecharse en episodios abruptos de hemoptisis.
Immunocompetence in adults: more than HIV negative
Authors: Zea-Vera Andres Felipe 
Published: November 2019

I read a case report about Tuberculosis and fungal co-infection in a previously healthy patient published in Colomb Med (Cali) by Fontalvo et al., and I would like to address some related comments. Frequently clinicians report adult cases of patients with opportunistic infections as disseminated tuberculosis and/or fungal infections in patients consider as immunocompetent based mainly in the absence of human immunodeficiency virus infection (HIV negative). Immunocompetence is more complex than absence of HIV infection and involves a normal capacity to develop an immune response following the exposure to an antigen or broadly a normal immune response, but usually immunocompetent is define as the opposite of immunodeficiency. In the report authors said “Our aim is to report the case of an immunocompetent patient diagnosed with Mycobacterium tuberculosis and Candida albicans co-infections” but my deliberation is Do we make in the clinical practice all the efforts to consider a patient as immunocompetent? Mycobacterial, fungal and other opportunistic infections force the clinician to rule out a large list of conditions associated with secondary immunodeficiency as infectious agents (HIV, Herpesvirus, HTLV), drugs (steroids, immunosuppressants, biologics, chemotherapy) , metabolic diseases (diabetes, renal failure, cirrhosis), malignancies (leukemia, lymphomas and solid tumors) and environmental conditions (radiation, heavy metals) but even adult patients can have late onset primary genetic immunodeficiency
¿Son las redes sociales virtuales un espacio de ciudadanía?
Authors: Vallejos Silva Natalia , Redon Pantoja Silvia , Angulo Rasco Félix 
Published: December 2019

El presente artículo, da cuenta de los resultados de un proyecto de investigación denominado: “El sentido de lo común, de las redes sociales a las redes virtuales en educación”. El objetivo de este proyecto es comprender qué tipo de ciudadanía se configura a partir de las relaciones que adolescentes entre los 12 y los 18 años mantienen en las redes sociales virtuales (Online Social Networks, OLSN). De esta problemática, surgen dos líneas teóricas que fundamentan este propósito. En primer lugar, el concepto de ciudadanía, comprendido como un espacio social de convivencia y político de pertenencia. En segundo lugar, la gran presencia y despliegue del mundo virtual en la vida de los sujetos, como otro espacio de relaciones que podría articular formas distintas de construcción de lo político y la ciudadanía. El enfoque metodológico ha integrado distintas técnicas cualitativas: entrevistas etnográficas, grupos focales y análisis de contenido en las redes virtuales (social networks). Este artículo sólo da cuenta de los resultados centrados en las entrevistas etnográficas semiestructuradas y en los grupos focales. Los resultados analíticos de los discursos han generado dos grandes categorías que se vinculan con: 1. La ausencia de ciudadanía como territorio de lo común en las redes sociales virtuales y 2. La diferencia como exclusión y la anulación del conflicto: lo político versus la política.
TEOLOGIA E PÓS-MODERNIDADE: APONTAMENTOS PARA UM DISCURSO TEOLÓGICO RELEVANTE
Authors: Lima Adriano Sousa , Martins Jaziel Guerreiro 
Published: December 2019

O artigo reflete sobre o tema “Teologia e pós-modernidade: apontamentos para o discurso teológico relevante”. Tendo como objetivo discutir se a teologia pode sobreviver como discurso, como logos e quais seriam as suas chances, bem como alguns dos caminhos que ela poderia trilhar, o artigo enfrenta questões fundamentais para o debate religioso, no sentido amplo, e teológico, no sentido específico. Trata-se da busca de respostas para indagações antigas, mas sempre relevantes: a religião cristã e a teologia são pertinentes na pós-modernidade? Quais seriam os novos desafios para a teologia nesse contexto? Quais seriam os rumos da teologia na época pós-moderna? Para responder tais questionamentos, os autores analisam a literatura mais relevante e atual sobre o tema, visando contribuir no âmbito acadêmico, eclesial e social. Ao final, os autores destacam que para sobreviver num tempo pós-moderno, é fundamental que a teologia se lance à tarefa de decifrar as implicações da pós-modernidade para ela e para a igreja. A teologia precisará ainda desconstruir os paradigmas modernos da interpretação do texto bíblico, a fim de responder com mais consistência os questionamentos teológicos da pós-modernidade. Assim, os autores concluem que a pós-modernidade não é um mal a ser combatido, mas um período a ser discernido e ao mesmo tempo, enriquecedor e propositivo para a experiência religiosa e para o discurso teológico relevante.Palavras-chave: Teologia; Pós-Modernidade; Religião; Experiência. THEOLOGY AND POSTMODERNITY: NOTES FOR A RELEVANT THEOLOGICAL DISCOURSEAbstractThe article adresses the topic “Theology and post-modernity: notes for a relevant theological discourse”. It discusses if Theology may thrive as a discourse, as a logos and what are its chances, such as some ways that Theology may walk. This present research deals religious debate fundamental issues in broader and strict senses. So, it is about the search for answers to ancient, but always relevant questions: are Christian religion and Theology pertinent in post-modernity? Which are the new challenges for Theology in this context? Which are the possible paths for Theology in contemporary times? In order to answer these interrogations, the text analyses the most relevant and current literature on the topic, aiming to contribute in academic, ecclesial, and social environments. Finally, so that it may survive in post-modernity, it is paramount for Theology to engage the task of deciphering the implications of postmodernity for Theology itself and for the Church. Theology will need to deconstruct modern paradigms of biblical interpretation, so that it may consistently respond to postmodern theological issues. This way, postmodernity is not and evil to fight against, but a period that has to be discerned with wisdom and responsibility. It is an enriching propositional time concerning to religious experience and relevant theological speech.Keywords: Theology; Postmodernity; Religion; Experience.
FUNDAMENTALISMO RELIGIOSO CRISTÃO E ISLÂMICO: TENDÊNCIAS SOCIOPOLÍTICAS
Authors: Costa Marcio Luis , Messias Alex Silva 
Published: December 2019

Nas últimas décadas se observa o retorno da religião sob forma de fundamentalismo religioso, utilizando a mídia e instrumentos de pressão política para fazer valer suas crenças, pois diante do receio ao questionamento, os fundamentalistas veem no “outro”, no diferente, uma ameaça a ser combatida e, em alguns casos, extirpada para preservar suas convicções. O presente estudo tem por objetivo discutir as tendências sócio-políticas do fundamentalismo religioso cristão. Para tanto, com método bibliográfico narrativo, visitamos alguns autores em nível nacional e internacional, que abordam as condições que fizeram emergir o fenômeno social do fundamentalismo religioso, sua estruturação e atuação, até suas demandas sócio-políticas. Os resultados apontam que quando se identifica e transfere qualquer responsabilidade pessoal e histórica para as forças externas, o “outro”, entendido como pessoa e/ou instituição, não podemos negar que esse processo alcança dimensões de problema social. Notamos algumas tendências como mudança de movimento religioso para ideologia acirrada, da postura de fiel para militância, do “ad intra” das religiões para demandas “ad extra”, dos altares e púlpitos para ocupações políticas.Palavras-chave: Fundamentalismo Religioso; Protestante; Católico. CHRISTIAN RELIGIOUS FUNDAMENTALISM: SOCIAL-POLITICS TENDENCIESAbstractIn the last decades the return of religion in religious fundamentalism form can be observed, using media and instruments of political pressure, because when facing the fear of questioning, fundamentalists see in the “other”, in the different, a threat to be stopped and, in some cases, extirpated top preserve their convictions. This study aims to discuss the social-politics tendencies of the Christian religious fundamentalism. For that, with the narrative bibliographic method, we visited some authors of national and international level, that approach the conditions that caused the emergence of the religious fundamentalism social phenomenon, its structure and role, until its social-politics demand. The results show that when any personal or historical responsibility is identified and transferred to external forces, the “other”, understood as person and/or institution, we cannot deny this process reaches dimensions of social problem. We notice some tendencies such as the change of the religious movement to fierce ideology, from the posture of faithful to militancy, from “ad intra” of religions to “ad extra” demands, from the altars and pulpits to political positions.Keywords: Religious Fundamentalism; Protestant; Catholic.
Role of Alexithymia in Predicting Self-Efficacy in Academic Students of a North Indian Institution: A Cross Sectional Study
Authors: Devanshu Chaudhary  , Anjali Meena  
Published: November 2019

INTRODUCTION: Alexithymia is a cognitive-affective style and a personality construct that is associated with various physical and psychological disorders. It refers to a personality trait associated with difficulties with identifying or describing feelings, mental imaging and fantasy, and external cognitive orientation
AIM: To access the problem of alexithymia among the Academic (Dental and Ayurvedic) students of an Institution in North India.
MATERIALS AND METHOD: A questionnaire based cross-sectional survey was carried out among the medical students of D.J. Group of Institutions, Modinagar, Ghaziabad district, Uttar Pradesh, India. Ethical approval was obtained from the Institutional Review Board, Modinagar and informed consent was obtained from all the study participants prior to the study.
RESULTS: The questionnaire based study was carried out among 252 medical students of D.J. Group of Institutions, Modinagar, Ghaziabad district, Uttar Pradesh, India. Out of which 113 students were of Ayurveda and 139 were dental students. The inter group comparison of respondents according to course of study in which majority of the Ayurveda students were having significant result for the alexithymia problem.
CONCLUSION: This study demonstrates that alexithymia plays significant role in decreasing self-efficacy in academic students. As alexithymia is high in college students and affects self-regulation, goal orientation, and academic function, we suggest that mental physicians routinely evaluate medical college students for alexithymia.
A Systematic Review on Sleep Related Disorders and Periodontal Disease
Authors: Rahul Kumar  , Rupali Kalsi  , Stuti Gupta  , Neetika Gupta  
Published: November 2019

BACKGROUND: Periodontitis has been implicated in many systemic diseases such as diabetes, cardiovascular diseases, hypertension, stroke, Obesity, Kidney disorders. Recent scientific evidence has revealed a relationship between sleep related breathing disorders (SRBDs) and periodontal diseases. There has been a recent scientific evidence on population based studies reflecting an association between periodontal diseases and OSA.
AIM: The tenet of the study was to find out interconnect between obstructive sleep apnea and periodontal disease.
METHODS: A systematic review of clinical trials assessing the relationship between OSA and periodontitis was carried out. An electronic search based on internet search sites (From 2000-2016) by PubMed, MEDLINE, SCOPUS, EMBASE, Google scholar, CINAHL, and Web of Science (WoS) were used. Studies which met the inclusion criteria were further analysed to find out the outcome of the study.
RESULTS: A total of 174 potentially qualifying studies were screened. Out of them 10 studies fulfilled the inclusion criteria which were further analysed. In our study 10 studies (2000-2016) from Jordan, Tokyo, Turkey, Saudi Arabia, India, USA, South Korea, Taiwan, Australia were shortlisted. Out of them 5 were cross sectional studies, 4 were case control, and 1 was meta-analysis. The sample size in the studies ranged from 66 to 30,120 adult falling in age range of 18 to 75. The indicators for OSA used were as positive Epsworth sleepiness scale (ESS), Berlin Questionnaire, STOP-bang questionnaire, Apnea-Hypopnea index, Polysomnography (PSG). And the indicators for periodontal disease were Plaque index (PI), Clinical attachment level (CAL), Pocket Probing Depth (PPD), Gingival Bleeding Index (GBI). Majority of studies showed positive correlation between OSA and periodontal disease.
CONCLUSION: Recent evidence and literature suggests that there exist a strong interconnect between OSA and periodontal disease. Dentist play a pivotal role in diagnosis and timely management of OSA cases so as to halt progression of sleep apnea and periodontitis.
Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds
Authors: Ray Sandipan , Lach Radoslaw , Heesom Kate J , Valekunja Utham K , Encheva Vesela , Snijders Ambrosius P , Reddy Akhilesh B 
Published: December 2019

Determining the exact targets and mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock-related disorders. Here, we have used phenotypic proteomic profiling (PPP) to systematically determine molecular targets of four circadian period–lengthening compounds in human cells. We demonstrate that the compounds cause similar changes in phosphorylation and activity of several proteins and kinases involved in vital pathways, including MAPK, NGF, B-cell receptor, AMP-activated protein kinases (AMPKs), and mTOR signaling. Kinome profiling further indicated inhibition of CKId, ERK1/2, CDK2/7, TNIK, and MST4 kinases as a common mechanism of action for these clock-modulating compounds. Pharmacological or genetic inhibition of several convergent kinases lengthened circadian period, establishing them as novel circadian targets. Finally, thermal stability profiling revealed binding of the compounds to clock regulatory kinases, signaling molecules, and ubiquitination proteins. Thus, phenotypic proteomic profiling defines novel clock effectors that could directly inform precise therapeutic targeting of the circadian system in humans.
TINJAUAN DEBIT PADA SUMUR AIR TANAH BERBASIS POMPA AIR TENAGA SURYA
Authors: Iqbal Muh. taufik , Kushari Kushari 
Published: December 2019

To optimize the planting of rice plants, groundwater is used as a source of water so that the water needs for agricultural land can be met. Groundwater, which is a source of water, is known to contribute greatly to agricultural production, especially in the dry season. The long-term goal of this research is to increase groundwater discharge using a water pump as a controller of water distribution, alternative energy in the form of solar energy is used to drive the pump engine. During this time the pump is driven by an oil-fueled engine (BBM) which produces CO2 emissions into the air. The use of non-fuel alternative energy is expected to help reduce CO2 emissions so far. The research method begins with a survey and field survey conducted by the groundwater irrigation network in the Pare-Pare district. then search along ground waterways and mark using GPS. Measuring discharge and analyzing the performance of solar water pumps. To optimize the planting of rice plants, groundwater is used as a source of water so that the water needs for agricultural land can be met. Groundwater, which is a source of water, is known to contribute greatly to agricultural production, especially in the dry season. The long-term goal of this research is to increase groundwater discharge using a water pump as a controller of water distribution, alternative energy in the form of solar energy is used to drive the pump engine. During this time the pump is driven by an oil-fueled engine (BBM) which produces CO2 emissions into the air. The use of non-fuel alternative energy is expected to help reduce CO2 emissions so far. The research method begins with a survey and field survey conducted by the groundwater irrigation network in the Pare-Pare district. then search along ground waterways and mark using GPS. Measuring discharge and analyzing the performance of solar water pumps.
PERBEDAAN PENGARUH PEMBERIAN ANGKAK DALAM PEMBUATAN SOSIS AYAM TERHADAP SIFAT FISIK DAN ORLAB
Authors: Sudjatinah Sudjatinah , Wibowo C. Hari 
Published: November 2019

<p>Sosis daging ayam adalah bahan pangan yang berasal dari potongan kecil daging ayam yang digiling dan diberi bumbu. Bahan sosis yang digunakan adalah daging ayam, karena daging merupakan <em>white meat</em> jadi terlihat pucat jika diolah menjadi sosis berbeda dengan sosis daging sapi, oleh karena itu dilakukan penambahan pewarna alami yang aman dikonsumsi yaitu angkak. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan pengaruh konsentrasi angkak sebagai pewarna alami terhadap sifat fisik dan orlab sosis daging ayam.</p><p>Metode yang digunakan dalam penelitian ini adalah metode <em>experimental laboratories</em>. Faktor perlakuan yang diterapkan adalah tanpa penambahan angkak (0 %) dan penambahan angkak 1,5 %. Variabel yang diamati yaitu sifat fisik (kadar air, cooking loss), kekenyalan dan orlab. Data yang diperoleh dianalisis menggunakan <em>t test</em>. Hasil penelitian yang telah dilakukan menunjukkan bahwa perlakuan penambahan angkak dengan konsentrasi yang berbeda dalam pembuatan sosis daging ayam afkir (sebagai pewarna alami) berpengaruh nyata (p&lt;0,05) terhadap rata-rata cooking loss tetapi tidak berbeda pada rata-rata kadar air dan kekenyalan. Penambahan angkak dengan konsentrasi 1,5% pada pengolahan sosis daging ayam (sebagai pewarna alami) menghasilkan karakteristik mutu sosis daging ayam yang lebih baik dengan syarat mutu sosis daging ayam dibandingkan tanpa penambahan angkak. </p>
RASPBERRY PI DENGAN MODUL KAMERA DAN MOTION SENSOR SEBAGAI SOLUSI CCTV LAB FTIK UNIV. SEMARANG
Authors: Pramono Basworo Ardi , Hendrawan Aria , Daru April Firman 
Published: November 2019

<p>Pengawasan tempat/ruangan dalam pekerjaan merupakan hal penting, dimana dengan adanya CCTV pemantau kita bisa melihat kondisi suatu tempat dengan bantuan kamera pemantau (CCTV). Selama ini untuk perekaman CCTV mengunakan DVR (Digital Video Recording) dimana perangkat ini cenderung mahal dan belum menjangkau semua kalangan. Terlebih lagi jika CCTV merekam secara terus menerus 24 jam sehari selama 1 bulan, tentu harus menyediakan kapasitas ruang harddisk yang besar.</p><p>Ruang Lab FTIK menjadi objek penelitian dimana mengunakan perangkat raspberry pi dengan modul kamera dan sensor motion detection dimana perangkat PC Mini Raspberry Pi hanya akan merekam kondisi ruangan hanya pada saat terdeteksi suatu gerakan pada ruang Lab FTIK. Raspberry pi sendiri adalah sebuah komputer mini, sistem operasi Raspberry bisa bermacam-macam, salah satunya adalah Linux Debian yang telah dipaket minikan. Dengan itu diharapkan mampu mengurangi beban media penyimpanan. Penggunaan Raspberry Pi dalam hal pengawasan/monitoring tempat atau ruangan memerlukan biaya yang murah dan efektif dalam pendayagunaan.</p>