bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene signatures and prognostic values of m1A-related regulatory genes in hepatocellular carcinoma
Authors: Shi Qingmiao , Xue Chen , Yuan Xin , He Yuting , Yu Zujiang 
Published: September 2020

AbstractHepatocellular carcinoma (HCC) ranks fourth in cancer-related mortality worldwide. N1-methyladenosine (m1A), a methylation modification on RNA, is gaining attention for its role across diverse biological processes. However, m1A-related regulatory genes expression, its relationship with clinical prognosis, and its role in HCC remain unclear. In this study, we utilized The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) database to investigate alterations within 10 m1A-related regulatory genes and observed a high mutation frequency (23/363). Cox regression analysis and least absolute shrinkage and selection operator were used to explore the association between m1A-related regulatory genes expression and HCC patient survival and identified four regulators that were remarkably associated with HCC patient prognosis. Additionally, an independent cohort from International Cancer Genome Consortium was studied to validate our discoveries and found to be consistent with those in the TCGA dataset. In terms of mechanism, gene set enrichment analysis linked these four genes with various physiological roles in cell division, the MYC pathway, protein metabolism, and mitosis. Kyoto Encyclopedia of Genes and Genomes analysis revealed that PI3K/Akt signaling pathway had potential relevance to m1A-related regulatory genes in HCC. These findings indicate that m1A-related regulatory genes may play crucial roles in regulating HCC progression and be exploited for diagnostic and prognostic purposes.
Continuous preparation of antimony nanocrystals with near infrared photothermal property by pulsed laser ablation in liquids
Authors: Kou Juanrong , Wang Yongkai , Liu Xiaoyu , Zhang Xianju , Chen Gaoyu , Xu Xiangxing , Bao Jianchun , Yang Kaili , Yuwen Lihui 
Published: September 2020

AbstractAntimony nanocrystals (Sb NCs) are of interest in energy storage, catalysis and cancer therapy for its special physical, chemical and biomedical properties. However, methodology challenges still remain in preparation of colloidal Sb NCs, due to the restricted reaction solution systems, high temperature and time costing for common routes. Herein, size controllable colloidal Sb NCs were continuously prepared by pulsed laser ablation of Sb target in different solvents, owning to the metal nanodroplet explosive ejection and thermal evaporation mechanisms. These well dispersed and stable Sb NCs showed excellent photothermal property in the near-infrared-II window.
Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans
Authors: Lee Mi-Kyung , Son Ye-Eun , Park Hee-Soo , Alshannaq Ahmad , Han Kap-Hoon , Yu Jae-Hyuk 
Published: September 2020

AbstractMcrA is a key transcription factor that functions as a global repressor of fungal secondary metabolism in Aspergillus species. Here, we report that mcrA is one of the VosA-VelB target genes and McrA governs the cellular and metabolic development in Aspergillus nidulans. The deletion of mcrA resulted in a reduced number of conidia and decreased mRNA levels of brlA, the key asexual developmental activator. In addition, the absence of mcrA led to a loss of long-term viability of asexual spores (conidia), which is likely associated with the lack of conidial trehalose and increased β-(1,3)-glucan levels in conidia. In supporting its repressive role, the mcrA deletion mutant conidia contain more amounts of sterigmatocystin and an unknown metabolite than the wild type conidia. While overexpression of mcrA caused the fluffy-autolytic phenotype coupled with accelerated cell death, deletion of mcrA did not fully suppress the developmental defects caused by the lack of the regulator of G-protein signaling protein FlbA. On the contrary to the cellular development, sterigmatocystin production was restored in the ΔflbA ΔmcrA double mutant, and overexpression of mcrA completely blocked the production of sterigmatocystin. Overall, McrA plays a multiple role in governing growth, development, spore viability, and secondary metabolism in A. nidulans.
Information content best characterises the hemispheric selectivity of the inferior parietal lobe: a meta-analysis
Authors: Gray Oliver , Fry Lewis , Montaldi Daniela 
Published: September 2020

AbstractOur understanding of the inferior parietal lobe (IPL) remains challenged by inconsistencies between neuroimaging and neuropsychological perspectives. To date, others assume that hemispheric specialisation of the IPL is linked with the type of processing; attention processing in the right hemisphere; memory retrieval and semantic judgement in the left hemisphere. Here, we provide compelling evidence associating the type of information being processed with the recruitment of each hemisphere’s IPL. In a meta-analysis, we classify 121 previous fMRI reports of IPL activity arising from episodic memory retrieval, according to the type of information that characterises each fMRI contrast. We demonstrate that the left IPL is more consistently associated with retrieval of the semantic (95% of eligible contrasts) than perceptual aspects of memory (83%). In contrast, the right IPL is more consistently associated with the retrieval of perceptual (97%), than semantic aspects of memory (43%). This work revises assumptions of how the IPL contributes to healthy cognition and has major implications for IPL-related neuropsychological deficits.
Electronic decoupling of polyacenes from the underlying metal substrate by sp3 carbon atoms
Authors: Mohammed Mohammed S. G. , Colazzo Luciano , Robles Roberto , Dorel Ruth , Echavarren Antonio M. , Lorente Nicolás , de Oteyza Dimas G. 
Published: September 2020

AbstractOn-surface synthesis is becoming an increasingly popular approach to obtain new organic materials. In this context, metallic surfaces are the most commonly used substrates. However, their hybridization with the adsorbates often hinder a proper characterization of the molecule’s intrinsic electronic and magnetic properties. Here we report a route to electronically decouple molecules from their supporting substrates. In particular, we have used a Ag(001) substrate and hydrogenated heptacene molecules, in which the longest conjugated segment determining its frontier molecular orbitals amounts to five consecutive rings. The non-planarity that sp3 atoms impose on the carbon backbone results in electronically decoupled molecules, as demonstrated by scanning tunneling spectroscopy measurements. The charging resonances of the latter imply the presence of double tunneling barriers. We further explain the existing relation between the charging resonance energy and their contrast, as well as with the presence or absence of additional Kondo resonances.
Living optical random neural network with three dimensional tumor spheroids for cancer morphodynamics
Authors: Pierangeli D. , Palmieri V. , Marcucci G. , Moriconi C. , Perini G. , De Spirito M. , Papi M. , Conti C. 
Published: September 2020

AbstractOptical neural networks process information at the speed of light and are energetically efficient. Photonic artificial intelligence allows speech recognition, image classification, and Ising machines. Modern machine learning paradigms, as extreme learning machines, reveal that disordered and biological materials may realize optical neural networks with thousands of nodes trained only at the input and at the readout. May we use living matter for machine learning? Here, we employ living three-dimensional tumor brain models to demonstrate a random optical learning machine (ROM) for the investigation of glioblastoma. The tumor spheroid act as a computational reservoir. The ROM detects cancer morphodynamics by laser-induced hyperthermia, quantifies chemotherapy, and cell metabolism. The ROM is a sensitive noninvasive smart probe for cytotoxicity assay and enables real-time investigation of tumor dynamics. We hence design and demonstrate a novel bio-hardware for optical computing and the study of light/complex matter interaction.
A quantitative hydroclimatic context for the European Great Famine of 1315–1317
Authors: Baek Seung H. , Smerdon Jason E. , Dobrin George-Costin , Naimark Jacob G. , Cook Edward R. , Cook Benjamin I. , Seager Richard , Cane Mark A. , Scholz Serena R. 
Published: September 2020

AbstractThe European Great Famine of 1315–1317 triggered one of the worst population collapses in European history and ranks as the single worst European famine in mortality as a proportion of population. Historical records point to torrential rainfall, land saturation, crop failure, and prolonged flooding as important causes of the famine. Here we use the tree-ring based Old World Drought Atlas (OWDA) to show that the average of each growing season preceding the Great Famine years (1314–1316) was the fifth wettest over Europe from 1300 to 2012 C.E. The spatial and temporal characteristics of our OWDA-estimated anomalies are in excellent agreement with available historical accounts. We also characterize a mode of European hydroclimate variability that is associated with the Great Famine, which we term the “Great Famine mode.” This mode emerges as the leading mode of European hydroclimate variability from 1300–2012 and is strongly associated with extreme wet and dry events in Europe over the last millennium.
Neuromotor Control of Speech and Speechlike Tasks: Implications From Articulatory Gestures
Authors: Rong Panying 
Published: September 2020

PurposeThis study aimed to provide a preliminary examination of the articulatory control of speech and speechlike tasks based on a gestural framework and identify shared and task-specific articulatory factors in speech and speechlike tasks.MethodTen healthy participants performed two speechlike tasks (i.e., alternating motion rate [AMR] and sequential motion rate [SMR]) and three speech tasks (i.e., reading of “clever Kim called the cat clinic” at the regular, fast, and slow rates) that varied in phonological complexity and rate. Articulatory kinematics were recorded using an electromagnetic kinematic tracking system (Wave, Northern Digital Inc.). Based on the gestural framework for articulatory phonology, the gestures of tongue body and lips were derived from the kinematic data. These gestures were subjected to a fine-grained analysis, which extracted (a) four gestural features (i.e., range of magnitude [ROM], frequency [Freq], acceleration time, and maximum speed [maxSpd]) for the tongue body gesture; (b) three intergestural measures including the peak intergestural coherence (InterCOH), frequency at which the peak intergestural coherence occurs (Freq_InterCOH), and the mean absolute relative phase between the tongue body and lip gestures; and (c) three intragestural (i.e., interarticulator) measures including the peak intragestural coherence (IntraCOH), Freq_IntraCOH, and mean absolute relative phase between the tongue body and the jaw, which are the component articulators that underlie the tongue body gesture. In addition, the performance rate for each task was also derived. The effects of task and sex on all the articulatory and behavioral measures were examined using mixed-design analysis of variance followed by post hoc pairwise comparisons across tasks.ResultsTask had a significant effect on performance rate, ROM, Freq, maxSpd, InterCOH, Freq_InterCOH, IntraCOH, and Freq_IntraCOH. Compared to the speech tasks, the AMR task showed a decrease in ROM and increases in Freq, InterCOH, Freq_InterCOH, IntraCOH, and Freq_IntraCOH. The SMR task showed similar ROM, Freq, maxSpd, InterCOH, and IntraCOH as the fast and regular speech tasks.ConclusionsThe simple phonological structure and demand for rapid syllable rate for the AMR task may elicit a distinct articulatory control mechanism. Despite being a rapid nonsense syllable repetition task, the relatively complex phonological structure of the SMR task appeared to elicit a similar articulatory control mechanism as that of speech production. Based on these shared and task-specific articulatory features between speech and speechlike tasks, the clinical implications for articulatory assessment were discussed.
Clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma: two case reports and literature review
Authors: Feng Dalin , Wang Mingshuai , Zhang Xiaodong , Wang Jianwen 
Published: September 2020

Abstract
Background The objective of this study is to discuss clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma on the basis of 2 cases and to review recent literature, in order to present medical advances.
Methods A 29-year old male patient came to our hospital because of a huge tumour on the right kidney. Enhanced CT showed that the tumour was about 15.5*10.5 cm, and was considered to be malignant. Another case was a 38-year old female patient. She complained was found to have a right kidney tumour in a routine physical examination. Enhanced CT showed an early-stage tumour of about 4.3*3.7 cm on the lower pole of the right kidney. The male patient underwent open radical nephrectomy and the female patient underwent laparoscopic radical nephrectomy and extensive retroperitoneal lymph node dissection. The two patients underwent genetic testing and were diagnosed as having hereditary leiomyomatosis with renal cell carcinoma.
Results The postoperative pathology in both patients revealed type 2 papillary renal cell carcinoma but with different prognosis. The male patient suffered multiple metastasis 10 months post-operation. The metastatic tumour of the abdominal wall was resected to confirm recurrence and hereditary leiomyomatosis renal cell carcinoma was diagnosed by the genetic test. While the female patient had a specific family history and uterine leiomyomas, the genetic test helped us to identify hereditary leiomyomatosis renal cell carcinoma pre-operation. Because of the early diagnosis and timely treatment, the female patient was considered to have a good prognosis.
Conclusion Hereditary leiomyomatosis renal cell carcinoma is a rare hereditary disease resulting from FH gene mutation. There are currently no effective treatments.Our cases demonstrate that hereditary leiomyomatosis renal cell carcinoma is a very aggressive disease. Early screening and surveillance are recommended for patients with a family history or who are at risk of hereditary leiomyomatosis renal cell carcinoma. Surgical and palliative therapy still play an important role in clinical treatment.
Schritt für Schritt entlang der kinetischen Kette
Authors: Geerse Wouter K. 
Published: September 2020

ZusammenfassungKann ein lang zurückliegendes Sprunggelenktrauma zu rezidivierenden Rückenschmerzen führen? Das Fallbeispiel zeigt: Zumindest kann es einen Einfluss haben, denn erst das Einbeziehen der Sprunggelenkregion in die Therapie macht das Beach-Volleyballspiel wieder zum Vergnügen für die 28-jährige Patientin.
Eine seltene Ursache einer eosinophilen Lungenerkrankung
Authors: Stolpe C. , Tannapfel A. 
Published: September 2020

ZusammenfassungEin 47-jähriger Patient mit langjährig bekanntem Asthma bronchiale, chronischer Rhinosinusitis und langjähriger Epilepsie stellte sich aufgrund von progredienter Dyspnoe und Abgeschlagenheit in der pneumologischen Praxis vor. In einer thorakalen Röntgenaufnahme und einer nachfolgend durchgeführten thorakalen Computertomografie zeigten sich multiple pulmonale Rundherde.Eine Bronchoskopie mit bronchoalveolärer Lavage und transbronchialer Biopsie erbrachte den Befund einer eosinophilen Bronchitis und Alveolitis ohne Nachweis maligner Zellen. Nach Einleitung einer immunsuppressiven Therapie mit oralem Prednisolon und Umstellung der antikonvulsiven Therapie von Valproinsäure auf Levetiracetam besserten sich Dyspnoe und Belastbarkeit des Patienten binnen weniger Monate, einhergehend mit einem Regress der pulmonalen Rundherde und der peripheren Eosinophilie.Eine pulmonale Eosinophilie erfordert eine gründliche differenzialdiagnostische Aufarbeitung. Bei diesem Patienten ist am ehesten von einer eosinophilen Granulomatose mit Polyangiitis auszugehen. In der Literatur finden sich aber auch Fallberichte zu Valproinsäure-induzierten eosinophilen Lungenerkrankungen, sodass auch hier eine Assoziation denkbar ist.
Insights Into the Controversial Aspects of Adiponectin in
Cardiometabolic Disorders
Authors: Francischetti Emilio Antonio , Dezonne Rômulo Sperduto , Pereira Cláudia Maria , de Moraes Martins Cyro José , Celoria Bruno Miguel Jorge , de Oliveira Patrícia Aguiar Cardoso , de Abreu Virgínia Genelhu 
Published: September 2020

AbstractIn 2016, the World Health Organization estimated that more than 1.9 billion
adults were overweight or obese. This impressive number shows that weight excess
is pandemic. Overweight and obesity are closely associated with a high risk of
comorbidities, such as insulin resistance and its most important outcomes,
including metabolic syndrome, type 2 diabetes mellitus, and cardiovascular
disease. Adiponectin has emerged as a salutary adipocytokine, with
insulin-sensitizing, anti-inflammatory, and cardiovascular protective
properties. However, under metabolically unfavorable conditions, visceral
adipose tissue-derived inflammatory cytokines might reduce the transcription of
the adiponectin gene and consequently its circulating levels. Low circulating
levels of adiponectin are negatively associated with various conditions, such as
insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and
cardiovascular disease. In contrast, several recent clinical trials and
meta-analyses have reported high circulating adiponectin levels positively
associated with cardiovascular mortality and all-cause mortality. These results
are biologically intriguing and counterintuitive, and came to be termed
“the adiponectin paradox”. Adiponectin paradox is frequently
associated with adiponectin resistance, a concept related with the
downregulation of adiponectin receptors in insulin-resistant states. We review
this contradiction between the apparent role of adiponectin as a health promoter
and the recent evidence from Mendelian randomization studies indicating that
circulating adiponectin levels are an unexpected predictor of increased
morbidity and mortality rates in several clinical conditions. We also critically
review the therapeutic perspective of synthetic peptide adiponectin receptors
agonist that has been postulated as a promising alternative for the treatment of
metabolic syndrome and type 2 diabetes mellitus.
Arthroscopic Assisted Reconstruction of LT-Ligament: A Description of a New Technique
Authors: Haugstvedt Jan Ragnar , Rigó István Zoltán 
Published: September 2020

Abstract
Background Injuries of the lunotrirquetral ligament (LT lig) could be part of an extensive carpal injury and are then often treated at the time of the injury. However, when an injury of the LT ligament occurs alone, the injury is often missed. Treatment of this injury has traditionally been by open surgery, such as reattachment of the LT ligament, ligament reconstruction, or arthrodesis of the LT joint. These procedures needed a large exposure to the carpus running the risk of damaging the external ligaments, the nerves important for proprioception, and the capsule with the potential of scarring and adhesions.
Materials and Methods We describe a novel arthroscopic assisted technique for reconstruction of the LT ligament. Using this less invasive technique, there is a possible advantage of lesser scarring and faster mobilization.
Results We have performed this technique in two patients with more than 30 months follow-up. They both have great improvement of the functional scores.
Conclusion The novel arthroscopic assisted technique for LT lig reconstruction is a technically demanding procedure; however, this obtains good clinical results with more than 30 months follow-up due to less exposure of the carpus.
Level of Evidence This is a Level IV, case series study.
Investigating the Level of Knowledge of the Community about Oral and Dental Health
Authors: Birant Sinem , Koruyucu Mine , Ozcan Hazal , Ilisulu Ceren , Kasimoglu Yelda , Ustun Nilufer , Kocaaydin Simin , Bektas Dilara , Usta Gulsevim , Akay Tekin Cansu , Bekiroglu Nural , Seymen Figen 
Published: September 2020

Abstract
Objectives This study aimed to determine the knowledge and approaches of the participants about oral and dental health.
Materials and Methods This was a questionnaire-based cross-sectional survey. Participants’ demographic characteristics, tooth brushing habits, selection of toothpaste, and reasons for visiting the dentist were examined in this study. Participants’ knowledge levels of fluoride and their attitudes toward the most common fluoride applications among preventive treatments were also evaluated. Data entry and analyses were performed using SPSS statistical software. Descriptive and inferential statistics and chi-square test were used for analyzes.
Results A total of 2,744 voluntary participants including 1,938 (70.6%) females and 806 (29.4%) males responded; 1,391 (50.7%) participants know the contents of their toothpaste; 1,680 (61.2%) participants point out that fluoride is effective in preventing dental caries. Female participants reported a statistically significant difference in their knowledge of what is fluoride when compared with male participants (p = 0.0001). The knowledge level of participants who had higher levels of education were statistically significantly different when compared with the participants who had lower education levels about fluoride and fluoride applications (p = 0.0001).
Conclusions The results of this study indicate that participants’ attitudes toward oral health and dental care need to be improved.
National population mapping from sparse survey data: A hierarchical Bayesian modeling framework to account for uncertainty
Authors: Leasure Douglas R. , Jochem Warren C. , Weber Eric M. , Seaman Vincent , Tatem Andrew J. 
Published: September 2020

Significance
High-resolution population estimates are essential for government planning, development projects, and public health campaigns, but countries where this information is most needed are often where recent national census data are least available. We present a modeling framework that combines recent neighborhood-scale microcensus surveys with national-scale data from satellite images and digital maps to estimate population sizes for every 100-m grid square nationally. We present a case study from Nigeria where population estimates with national coverage were produced using household survey data from 1,141 locations. This work represents a significant step toward achieving high-resolution population estimates with national coverage from sparse population data while providing reliable estimates of uncertainty at any spatial scale.
Emergence of anomalous dynamics in soft matter probed at the European XFEL
Authors: Lehmkühler Felix , Dallari Francesco , Jain Avni , Sikorski Marcin , Möller Johannes , Frenzel Lara , Lokteva Irina , Mills Grant , Walther Michael , Sinn Harald , Schulz Florian , Dartsch Michael , Markmann Verena , Bean Richard , Kim Yoonhee , Vagovic Patrik , Madsen Anders , Mancuso Adrian P. , Grübel Gerhard 
Published: September 2020

Significance
The European XFEL is a hard X-ray Free-Electron Laser (FEL) with pulse repetition rates in the megahertz regime. Thus, sample dynamics in the microsecond and submicrosecond regime can be accessed by means of X-ray photon correlation spectroscopy (XPCS). Application of XPCS at FEL sources has been challenged because of the intrinsic fluctuations of FELs and the radiation-induced sample heating and damage. In this work we demonstrate the unprecedented stability of the European XFEL and show the feasibility of microsecond XPCS on a model system. Nonlinear heating on microsecond timescales is observed reaching superheated water states that persist up to 100 μs. Our data indicate a violation of the Stokes–Einstein relation for nanoparticle diffusion at short times.