bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel mediation effect of consumption values and the moderation effect of innovativeness, in predicting the influence of identity on green purchasing behavior
Authors: Mutum Dilip S. , Ghazali Ezlika M. , Wei‐Pin Woon 
Published: December 2020

AbstractThis study investigates the mechanism by which proenvironmental self‐identity (PESI) predicts green purchasing behavior (GPB) through various dimensions of green consumption values, following the recently published modern‐mediation‐analysis guidelines. The model was examined via 1,186 validated survey responses from experienced green consumers. Data were analyzed using partial least squares structural equation modeling technique. Results demonstrate that the relationship between PESI and GPB is mediated by emotional, epistemic, social, and health values. The results, however, did not find support for mediation effects of conditional and functional values. In addition, consumer innovativeness was found to moderate the relationship between PESI and three out of five values (conditional, functional, and social values) examined. This study indicates that promoting the advantages of green products and strengthening PESI and consumption values are closely linked to GPBs. Additionally, peer referral appears to minimize the perceived risks associated with buying green products. Marketers of green products are encouraged to provide health‐related information such as calorie and nutritional content.
Decontamination of mycotoxigenic fungi on shelled corn using selective infrared heating technique
Authors: Wilson Shantae A. , Mohammadi Shad Zeinab , Oduola Abass A. , Zhou Zonghui , Jiang Hongrui , Carbonero Franck , Atungulu Griffiths G. 
Published: December 2020

AbstractBackground and objectivesMycotoxigenic fungi pose a severe threat to humans’ health and cause economic losses to crop growers. This study investigated the impact of selected wavelengths of infrared (IR), as a novel technique, followed by a tempering step to inactivate the fungi on shelled corn.FindingsAscomycota was found to be the most dominant phylum (95.6 and 93.2%, respectively) on corn treated with only IR and IR followed by a tempering. Among fungal genera, Aspergillus was the primary genus found on corn treated with only IR heat. However, a significant reduction in relative abundance of Aspergillus (22%) was obtained when corn with 16% moisture content (wet basis) was treated with the following set up: IR wavelength of 3.2 µm at product‐to‐emitter gap of 110 mm, and 60 s duration.ConclusionThe use of selected IR wavelengths is effective in inactivating mycotoxigenic fungi such as Aspergillus flavus. The further significant suppression of the mycotoxigenic fungi is feasible with incorporating a tempering step into the IR heat treatment.Significance and noveltyThe selected IR system is scalable for large scale industrial application, offering promises of reliable and rapid mycotoxigenic fungal inactivation on corn and other cereals.
Catheter‐related blood stream infection caused by Mycobacterium chelonae in a child with myeloid leukemia associated with Down syndrome
Authors: Fujikawa Tomoko , Uemura Suguru , Aoto Yuya , Nambu Yoshinori , Nagano China , Nakatani Naoko , Nino Nanako , Yamamoto Nobuyuki , Mori Takeshi , Nishimura Noriyuki , Iijima Kazumoto 
Published: December 2020

AbstractRapidly growing nontuberculous mycobacteria should be considered if GPRs gram‐positive rods are detected in blood cultures 2‐3 days after the blood sample collection.
Primary intraosseous osteolytic meningioma without an evidence of soft tissue invasion
Authors: Dolachee Ali Adnan , Hoz Samer S. , Lafta Ghazwan A. 
Published: December 2020

AbstractPrimary intraosseous osteolytic meningiomas are not common, and total surgical removal is the best treatment option if the location allows that; however, long‐term follow‐up is recommended since it may recur.
In Situ and Operando Techniques for Investigating Electron Transfer in Biological Systems
Authors: de Souza João C. P. , Macedo Lucyano J. A. , Hassan Ayaz , Sedenho Graziela C. , Modenez Iago A. , Crespilho Frank N. 
Published: December 2020

AbstractWhen bioelectrochemistry meets other analytical techniques for in situ experiments, new possibilities for understanding the nature of charge‐transfer reactions are provided. Despite progress in recent years in analytical instrumentation, a number of key issues remains for bioelectrochemistry, in terms of the mechanistic description of the surface reactions involved in biomolecules’ electron transfer. The main challenges of these techniques are the concomitant detection of electron transfer and molecular alteration as well as the development of suitable bioelectrodes. This review discusses the most recent and emerging in situ and operando electrochemical methods used to study biological systems such as redox proteins, nucleic acids, small biomolecules, cells, and biomembranes, focusing on electrochemical methods coupled with spectroscopic, spectrometric, and microscopic techniques.
Forward osmosis for multi‐effect distillation brine treatment: Performance and concentration polarization evaluation
Authors: Yang Ye , Sun Yuzhu , Song Xingfu , Yu Jianguo 
Published: December 2020

AbstractThe discharge of reject brine from seawater desalination processes is a threat to marine ecosystems. This study investigated the feasibility of forward osmosis (FO) for the treatment of reject brine from multi‐effect distillation (MED) systems. The performances of two commercial FO membranes (ie, cellulose triacetate (CTA) and polyamide thin film composite (TFC) membranes) were compared. The effects of operating conditions, such as draw solution concentration, cross‐flow velocity, and temperature, on concentration polarization and consequently on the water flux, were quantitatively analyzed using a mathematical model. Results showed that the batch FO process could effectively reduce the volume of MED brine to 54.9% using 3 mol/L NaCl. As the draw solution concentration increased from 1‐5 mol/L, a significant increase in the initial water flux from 3.23‐17.88 L · m−2 · h−1 and from 3.55‐24.04 L · m−2 · h−1 was observed for the CTA and TFC membranes, respectively. However, the proportions of the effective osmotic pressure differences decreased from 20.7% to 11.9% and from 23.5% to 6.2% for the CTA and TFC membranes, respectively, indicating the concentration polarization (CP) was severe for high‐salinity brine treatment. The positive effects of increasing cross‐flow velocity on CP were limited. Moreover, the high temperature of the MED brine effectively mitigated the internal concentration polarization (ICP), thereby enhancing the water flux. Overall, this study provides valuable guidance for the application and optimization of FO in MED brine treatment.
Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity**
Authors: Huwaimel Bader I. , Bhakta Myla , Kulkarni Chaitanya A. , Milliken Alexander S. , Wang Feifei , Peng Aimin , Brookes Paul S. , Trippier Paul C. 
Published: December 2020

AbstractMitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role in mitochondrial metabolism. Known but low potency CII inhibitors are selectively cytotoxic to cancer cells including the benzothiadiazine‐based anti‐hypoglycemic diazoxide. Herein, we study the structure‐activity relationship of benzothiadiazine derivatives for CII inhibition and their effect on cancer cells for the first time. A 15‐fold increase in CII inhibition was achieved over diazoxide, albeit with micromolar IC50 values. Cytotoxicity evaluation of the novel derivatives resulted in the identification of compounds with much greater antineoplastic effect than diazoxide, the most potent of which possesses an IC50 of 2.93±0.07 μM in a cellular model of triple‐negative breast cancer, with high selectivity over nonmalignant cells and more than double the potency of the clinical agent 5‐fluorouracil. No correlation between cytotoxicity and CII inhibition was found, thus indicating an as‐yet‐undefined mechanism of action of this scaffold. The derivatives described herein represent valuable hit compounds for therapeutic discovery in triple‐negative breast cancer.
The efficacy and mechanisms of a guided self‐help intervention based on mindfulness in patients with breast cancer: A randomized controlled trial
Authors: Shao Di , Zhang Huihui , Cui Naixue , Sun Jiwei , Li Jie , Cao Fenglin 
Published: December 2020

BackgroundMindfulness‐based interventions (MBIs) can alleviate psychological distress in patients with cancer. However, face‐to‐face MBIs may be inconvenient for patients. Therefore, guided self‐help interventions may be more accessible. The authors investigated the effects of a guided self‐help MBI for depression, anxiety, and sleep disorder symptoms in patients with breast cancer and explored the potential underlying mechanisms.MethodsOne hundred forty‐four postoperative patients with breast cancer were randomly assigned to an intervention group (6‐week guided self‐help MBI; n = 72) or a wait‐list control group (routine treatment; n = 72). Self‐reported depression, anxiety, sleep disorder symptoms, and rumination and worry as potential mediators were assessed at baseline and postintervention. Outcomes were then assessed at 1‐month and 3‐month follow‐up. The intervention's effects over time and the potential mediating effect were analyzed using generalized estimating equations. The trial was registered at the Chinese Clinical Registry (ChiCTR‐IOR‐16008073).ResultsSignificant improvements in depression and sleep disorder symptoms occurred in the intervention group compared with wait‐list controls, and the improvements were maintained at 1‐month and 3‐month follow‐up. Changes in rumination and worry mediated the intervention's effects on changes in depression and sleep disorder symptoms.ConclusionsA guided self‐help MBI reduced depressive and sleep disorder symptoms by mitigating rumination and worry in patients with breast cancer. These findings support benefits of this accessible psychological intervention in oncology and provide insight into possible mechanisms of action. The current research contributes to discovering effective and widely accessible means for people with physical health conditions and may remove barriers that otherwise would have precluded participation in face‐to‐face psychological interventions.
Validation of the caregiver Pediatric Patient‐Reported Outcomes Version of the Common Terminology Criteria for Adverse Events measure
Authors: Reeve Bryce B. , McFatrich Molly , Lin Li , Lucas Nicole R. , Mack Jennifer W. , Jacobs Shana S. , Withycombe Janice S. , Baker Justin N. , Freyer David R. , Hinds Pamela S. 
Published: December 2020

BackgroundDespite improvements in survival rates, cancer treatments have significant side effects that affect the quality of life of children and their families. When an ill child cannot self‐report symptoms (eg, he or she is too ill), caregiver (parent) reporting becomes critical. This study evaluates the validity and reliability of the caregiver‐reported Pediatric Patient‐Reported Outcomes version of the Common Terminology Criteria for Adverse Events (Ped‐PRO‐CTCAE [Caregiver]) measure.MethodsA diverse sample of caregivers with children receiving treatment at 9 oncology centers completed the Ped‐PRO‐CTCAE [Caregiver] measure, the Patient‐Reported Outcomes Measurement Information System® (PROMIS®) Parent Proxy measures, the Lansky Play‐Performance Scale (PPS), medication use questions, and Global Impressions of Change (GIC). Construct validity (including convergent, discriminant, and known groups validity and responsiveness over time) and reliability (stability) were examined.ResultsA majority of the 473 caregivers were female (85%), non‐Hispanic White (61%), and married (75%). Symptoms assessed with the Ped‐PRO‐CTCAE [Caregiver] and PROMIS Parent Proxy measures were strongly correlated (e.g., r for pain = 0.78; r for fatigue = 0.78; and r for depression = 0.83). Most of the Ped‐PRO‐CTCAE [Caregiver] item mean scores distinguished among PPS function levels and between children who did take medications for symptom control and children who did not. Changes in Ped‐PRO‐CTCAE [Caregiver] item mean scores were responsive to GIC over time. Test‐retest evaluation found moderate to high agreement (57.8%‐93.3%) over time.ConclusionsThis study found strong evidence for the convergent and discriminant validity, known groups validity, responsiveness, and stability of the Ped‐PRO‐CTCAE [Caregiver] measure in a large and diverse sample of caregivers. The caregiver perspective provides a valuable and unique insight into the experiences of children and adolescents undergoing cancer treatment.Lay Summary

Despite advances in cancer treatments, children and adolescents continue to suffer from treatment side effects, including pain, nausea, fatigue, and emotional distress, that can adversely affect quality of life for children and their families.

Although it is best for children to report how they are feeling, there are times when a child may be too young or too ill to self‐report.

This study provides critical evidence for a new type of questionnaire that allows the caregiver or parent to report accurately what the child is experiencing. This measure can be used to improve adverse event reporting and child cancer care.
Mathematical model of the auditory nerve response to stimulation by a micro‐machined cochlea
Authors: Yamazaki Hiroki , Tsuji Tetsuro , Doi Kentaro , Kawano Satoyuki 
Published: December 2020

AbstractWe report a novel mathematical model of an artificial auditory system consisting of a micro‐machined cochlea and the auditory nerve response it evokes. The modeled micro‐machined cochlea is one previously realized experimentally by mimicking functions of the cochlea [Shintaku et al, Sens. Actuat. 158 (2010) 183–192; Inaoka et al, Proc. Natl. Acad. Sci. USA 108 (2011) 18390–18395]. First, from the viewpoint of mechanical engineering, the frequency characteristics of a model device were experimentally investigated to develop an artificial basilar membrane based on a spring–mass–damper system. In addition, a nonlinear feedback controller mimicking the function of the outer hair cells was incorporated in this experimental system. That is, the developed device reproduces the proportional relationship between the oscillation amplitude of the basilar membrane and the cube root of the sound pressure observed in the mammalian auditory system, which is what enables it to have a wide dynamic range, and the characteristics of the control performance were evaluated numerically and experimentally. Furthermore, the stimulation of the auditory nerve by the micro‐machined cochlea was investigated using the present mathematical model, and the simulation results were compared with our previous experimental results from animal testing [Shintaku et al, J. Biomech. Sci. Eng. 8 (2013) 198–208]. The simulation results were found to be in reasonably good agreement with those from the previous animal test; namely, there exists a threshold at which the excitation of the nerve starts and a saturation value for the firing rate under a large input. The proposed numerical model was able to qualitatively reproduce the results of the animal test with the micro‐machined cochlea and is thus expected to guide the evaluation of micro‐machined cochleae for future animal experiments.
Detection and Sorting of Extracellular Vesicles and Viruses Using nanoFACS
Authors: Morales‐Kastresana Aizea , Welsh Joshua A. , Jones Jennifer C. 
Published: December 2020

AbstractExtracellular vesicles (EVs) are sub‐micron‐sized membranous spheres secreted by cells. EVs play a functional role as intercellular communicators and are associated with a number of diseases. Research into EVs is an area of growing interest due their many potential uses as therapeutic agents, as diagnostic and theranostic biomarkers, and as regulators of cellular biology. Flow cytometry is a popular method for enumerating and phenotyping EVs, even though the majority of EVs are below the detection sensitivity of most commercially available flow cytometers. Here, we present optimized protocols for EV labeling that increase the signal‐to‐noise ratio of EVs by removing residual antibody. Protocols for alignment of high‐resolution jet‐in‐air flow cytometers are also provided. Published 2020. U.S. Government.Basic Protocol 1: Bulk EV staining with CFSE protein binding dyeBasic Protocol 2: Antigen‐specific staining of EV markers with fluorochrome‐conjugated antibodiesBasic Protocol 3: Astrios EQ instrument setup and sample acquisitionBasic Protocol 4: Counting particles and EVs on Astrios EQ with spike‐in reference beads
Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2
Authors: Bachmann Fabio , Duthaler Urs , Meyer zu Schwabedissen Henriette E. , Puchkov Maxim , Huwyler Jörg , Haschke Manuel , Krähenbühl Stephan 
Published: December 2020

Metamizole is an analgesic and antipyretic drug used intensively in certain countries. Previous studies have shown that metamizole induces cytochrome (CYP) 2B6 and possibly CYP3A4. So far, it is unknown whether metamizole induces additional CYPs and by which mechanism. Therefore, we assessed the activity of 6 different CYPs in 12 healthy male subjects before and after treatment with 3 g of metamizole per day for 1 week using a phenotyping cocktail approach. In addition, we investigated whether metamizole induces CYPs by an interaction with the constitutive androstane receptor (CAR) or the pregnane X receptor (PXR) in HepaRG cells. In the clinical study, we confirmed a moderate induction of CYP2B6 (decrease in the efavirenz area under the plasma concentration time curve (AUC) by 79%) and 3A4 (decrease in the midazolam AUC by 68%) by metamizole. In addition, metamizole weakly induced CYP2C9 (decrease in the flurbiprofen AUC by 22%) and moderately CYP2C19 (decrease in the omeprazole AUC by 66%) but did not alter CYP2D6 activity. In addition, metamizole weakly inhibited CYP1A2 activity (1.79‐fold increase in the caffeine AUC). We confirmed these results in HepaRG cells, where 4‐MAA, the principal metabolite of metamizole, induced the mRNA expression of CYP2B6, 2C9, 2C19, and 3A4. In HepaRG cells with a stable knockout of PXR or CAR, we could demonstrate that CYP induction by 4‐MAA depends on CAR and not on PXR. In conclusion, metamizole is a broad CYP inducer by an interaction with CAR and an inhibitor of CYP1A2. Regarding the widespread use of metamizole, these findings are of substantial clinical relevance.
Remote Control of Near Infrared Emission with Lanthanide Complexes
Authors: Norel Lucie , Galangau Olivier , Al Sabea Hassan , Rigaut Stéphane 
Published: December 2020

AbstractMolecular luminescent switches form a unique and fascinating class of compounds whose luminescence response can be toggled with chemical or physical stimuli. Switchable near‐infrared (NIR) emitters are of major interest since they are compatible with in vivo imaging and have potential for advanced materials such as security tags. Of particular interest are the NIR emitting lanthanides, which feature narrow, sharp and intense emission lines originating from the f–f Laporte forbidden transitions. Although, these “fingerprints” are in general rather insensitive to surrounding media, they can be manipulated thanks to a proper engineering of the complex first or second coordination spheres. The resulting switching systems may thus find usefulness in various application fields. In this review, we selected representative examples of switchable lanthanide NIR emitters based on the most relevant stimuli, such as chemical, environmental, thermal, electrochemical and photochemical inputs.
Modified H2V3O8 to Enhance the Electrochemical Performance for Li‐ion Insertion: The Influence of Prelithiation and Mo‐Substitution
Authors: Söllinger Daniela , Karl Michael , Redhammer Günther J. , Schoiber Jürgen , Werner Valérie , Zickler Gregor A. , Pokrant Simone 
Published: December 2020

AbstractNanostructured H2V3O8 is a promising high‐capacity cathode material, suitable not only for Li+ but also for Na+, Mg2+, and Zn2+ insertion. However, the full theoretical capacity for Li+ insertion has not been demonstrated experimentally so far. In addition, improvement of cycling stability is desirable. Modifications like substitution or prelithiation are possibilities to enhance the electrochemical performance of electrode materials. Here, for the first time, the substitution of vanadium sites in H2V3O8 with molybdenum was achieved while preserving the nanostructure by combining a soft chemical synthesis approach with a hydrothermal process. The obtained Mo‐substituted vanadate nanofibers were further modified by prelithiation. While pristine H2V3O8 showed an initial capacity of 223 mAh g−1 and a retention of 79 % over 30 cycles, combining Mo substitution and prelithiation led to a superior initial capacity of 312 mAh g−1 and a capacity retention of 94 % after 30 cycles.
Catalytic Enhancement of Inductively Heated Fe3O4 Nanoparticles by Removal of Surface Ligands
Authors: Moura Natalia S. , Bajgiran Khashayar R. , Roman Cameron L. , Daemen Luke , Cheng Yongqiang , Lawrence Jimmy , Melvin Adam T. , Dooley Kerry M. , Dorman James A. 
Published: December 2020

AbstractHeat management in catalysis is limited by each material's heat transfer efficiencies, resulting in energy losses despite current thermal engineering strategies. In contrast, induction heating of magnetic nanoparticles (NPs) generates heat at the surface of the catalyst where the reaction occurs, reducing waste heat via dissipation. However, the synthesis of magnetic NPs with optimal heat generation requires interfacial ligands, such as oleic acid, which act as heat sinks. Surface treatments using tetramethylammonium hydroxide (TMAOH) or pyridine are used to remove these ligands before applications in hydrophilic media. In this study, Fe3O4 NPs are surface treated to study the effect of induction heating on the catalytic oxidation of 1‐octanol. Whereas TMAOH was unsuccessful in removing oleic acid, pyridine treatment resulted in a roughly 2.5‐fold increase in heat generation and product yield. Therefore, efficient surfactant removal has profound implications in induction heating catalysis by increasing the heat transfer and available surface sites.
Toward whole tissue imaging of axolotl regeneration
Authors: Masselink Wouter , Tanaka Elly M. 
Published: December 2020

AbstractThe axolotl is a highly regenerative organism and has been studied in laboratories for over 150 years. Despite a long‐standing fascination with regeneration in general and axolotl specifically, we are still scratching the surface trying to visualize and understand the complex cellular behavior that underlies axolotl regeneration. In this review, we will discuss the progress that has been made in visualizing these processes focusing on four major aspects: cell labeling approaches, the removal of pigmentation, reductionist approaches to perform live cell imaging, and finally recent developments applying tissue clearing strategies to visualize the processes that underly regeneration. We also provide several suggestions that the community could consider exploring, notably the generation of novel alleles that further reduce pigmentation as well as improvements in tissue clearing strategies.