bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant Stress and Anticancer of Peptide Chelate Selenium Element in vitro
Authors: Li Xian , Wang Xianjue , Liu Gang , Xu Yanan , Wu Xinlin , Yi Ru , Jin Feng , Sa Chula , Su Xiulan 
Published: October 2020

Abstract
This contribution reports a facile synthesis of anticancer bioactive peptides (ACBP) - functionalized selenium particles (ACBP-S-Se) with enhanced anticancer activities and a detailed mechanistic evaluation of its regulation of oxidative stress in vitro. Structural and chemical characterizations were proved by ultraviolet absorption spectrum (UV), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Nuclear magnetic resonance carbon (13C NMR) and hydrogen spectra (H NMR), scanning electron microscope (SEM), energy dispersive X-ray spectrom (EDX) and inductively coupled plasma mass spectrometry (ICP-MS). The results show that ACBP are effectively sulfhydrylation modification with S-acetylmercaptosuccinic anhydride (SAMSA) via chemical absorption. After the polypeptide was modified by sulfhydrylation, there were many sulfhydryl groups on the molecule, and the sulfhydryl group was used as the binding site of Se. A panel of selected human cancer cell lines demonstrated high susceptibility toward ACBP-S-Se and displayed significantly reduced proliferative abilities. Finally, the results presented herein suggest bioactive peptide chelate selenium element effectively inhibited the proliferation of MKN-45 and MKN-74 cell in vitro, which in turns allowed the successful application of the ACBP-S-Se in highly complex human cell lines. The related the regulation of oxidative stress gene is CDKN1A, CCNB1, TXN and MAP3K5, while CDKN1A and TXN have ability to protecting cells to reduce oxidative stress and promoting cell growth arrest. Therefore, the great potential exhibited by ACBP-S-Se could make them an ideal candidate as a chemotherapeutic agent for human cancers, especially for gastric cancer.
Strong enhancement of electron-impact-ionization processes in hot dense plasma by transient spatial localization
Authors: Zeng Jiaolong , Liu Pengfei , Gao Cheng , Li Yongjun , Yuan Jianmin 
Published: October 2020

Abstract

The current standard atomic collision theory cannot explain recent experiments on electron-ion collisional ionization processes in hot dense plasma. We suggest that the use of (distorted) plane waves for incident and scattered electrons is not adequate to describe dissipation during the ionization event. Random collisions with free electrons and ions in plasma cause electron matter waves to lose their phase, which results in partial decoherence of incident and scattered electrons. Such a plasma-induced transient spatial localization of the continuum-electron states signiﬁcantly modiﬁes the wave functions of continuum electrons, resulting in a strong enhancement of electron-ion collisional ionization of ions in plasma compared with isolated ions. We develop a theoretical formulation to calculate the diﬀerential and integral cross sections by incorporating the eﬀects of plasma screening and transient spatial localization. The approach is then used to investigate electron-impact ionization of ions in solid-density magnesium plasma and gives results that are consistent with experiment. The correlation of continuum-electron energies is modiﬁed and the integral cross sections and rates increase considerably in hot dense plasma. For ionization of Mg9+ e+ 1s2 2s 2S → 1s2 1S + 2e, the ionization cross sections increase several-fold and the rates increase by one order of magnitude. Our ﬁndings shed new insight on collisional ionization and three-body recombination and should aid in investigations of the transport properties and nonequilibrium evolution of hot dense plasma.
Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology
Authors: Hamed Samira M. , Elkhatib Walid F. , Khairallah Ahmed S. , Noreddin Ayman M. 
Published: October 2020

Abstract
Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 60,703 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Clade GR was the most frequently identified followed by G and GH. Chronological analysis revealed expansion in SARS-CoV-2 clades with D614Gmutations indicating adaptation-driven evolution. Of them, clade GH showed a slight regression. GR, GH and L clades prevail in countries with higher deaths. GR clade showed higher prevalence among severe/deceased patients. Metadata analysis showed higher (p > 0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female and children patients. Furthermore, severe disease/death was more prevalent (p < 0.05) in elderly than in adults/children. These findings uniquely provide an evidence-based evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality.
Pharmacological treatment for patients with coronavirus disease 2019: systematic review of randomized controlled trials
Authors: Abu-Raya Bahaa , Mijovic Hana , Donken Robine , Cabrera Adriana , Kitchin Vanessa , Chow Rachael , Leishman Rose , Pan Christina , Paquette Vanessa , Roberts Ashley , Sadarangani Manish 
Published: October 2020

Abstract
Background: The best treatment for COVID-19 is not known, with numerous agents under investigation. We determined the outcomes of patients with COVID-19 treated with different pharmacological agents. Methods: In this systematic review, we searched Ovid MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials for studies published between 1stJanuary and 12thAugust, 2020. We included randomized controlled trials (RCTs) of patients with COVID-19 treated with any pharmacological agent and compared with a different pharmacological agent, placebo or standard of care. Results: From 6346 citations, 19 studies were included, with an overall low risk of bias. Two RCTs evaluated the use of remdesivir in laboratory-confirmed moderate-to-severe COVID-19. One study found that 10 days of remdesivir was associated with shortened recovery time. Neither found reduction in mortality. One RCT found no association of lopinavir/ritonavir with time to clinical improvement, or mortality benefit. Two RCTs of hydrochloroquine in patients with mild, early disease demonstrated no reduction in disease severity, hospitalization rate, death or viral load. Two RCTs observed no association of hydrochloroquine in hospitalized patients with mild-to-moderate disease with virological clearance, improvement in symptoms, need for respiratory support or death. One RCT showed that the use of steroids was associated with improved survival in patients with moderate-to-severe disease, especially those requiring respiratory support. Conclusions: There is evidence for the benefit of steroids in patients with moderate-to-severe disease. Remdesivir might shorten recovery time in patients hospitalized with moderate-to-severe disease. There is currently no evidence to support the use of lopinavir/ritonavir or hydrochloroquine.Study’s Registration: PROSPERO CRD42020184433.
Testing the effect of new biopesticides on soilborne pathogens of vegetable diseases using DNA markers
Authors: Pavlovskaya N. E. , Gagarina I. N. , Gavrilova A. Yu. , Borodin D. B. 
Published: October 2020

In protected ground, vegetables are exposed to various pests and pathogens of viral, bacterial or fungal diseases. Growing vegetables indoors requires the elimination of all chemical treatments and control over pathogens and pests. In this regard, the application of sensitive methods based on molecular markers in the diagnostics of pathogens is highly relevant. In this work, polymerase chain reaction was used to identify the most common diseases of tomato (Xanthomonas euvesicatoria), cucumber (Ascochyta cucumis) and potato (Clavibacter michiganensis subsp. Sepedonicus) plants. It was established that early diagnosis of vegetable diseases using polymerase chain reaction allows rapid detection of trace amounts of pathogenic microorganisms thus facilitating selection of effective fungicidal preparations. The creation of biological protection for vegetable crops is relevant considering their nutritional importance. New biological methods for protecting vegetables in greenhouses were tested. Thus, the fungicidal effect of the authors’ patented preparation developed for pre-sowing treatment of vegetable seeds in protected ground on the pathogens of tomato black bacterial spot (Xanthomonas euvesicatoria) and cucumber stem hypertrophy (Ascochyta cucumis) was confirmed. Another preparation patented as a means of pre-sowing treatment of pea seeds demonstrated fungicidal action against the development of Phytophthora infectants on potato plants. It was observed that these preparations are effective at concentrations of 10-4 % for soaking seeds and double treatment of plants during the flowering period.
KOMPARASI MOTIVASI BELAJAR SISWA MATERI PERUBAHAN LINGKUNGAN DAN DAUR ULANG LIMBAH MELALUI METODE EVERYONE IS TEACHER HERE DAN GUIDED NOTE TAKING
Authors: Nur Safitri Uli , Khoiri Nur , Hariz Anif Rizqianti 
Published: October 2020

Motivasi belajar merupakan suatu dorongan yang berasal dari dalam diri sendiri maupun dari luar yang mempengaruhi peserta didik dalam kegiatan belajar. Permasalahan yang sering terjadi di kelas adalah kurangnya motivasi belajar siswa dan variasi metode pembelajaran yang dipakai oleh guru dalam proses pembelajaran biologi. Dalam setiap pembelajaran siswa terkadang tidak selalu semangat dalam belajar. Tujuan penelitian ini adalah Menjelaskan kriteria motivasi belajar siswa pada materi<em> </em>perubahan lingkungan dan daur ulang limbah menggunakan metode <em>everyone is teacher here </em>dan <em>guided note taking </em>dan<em> </em>Menganalisis perbedaan motivasi belajar siswa menggunakan metode <em>everyone is teacher here</em> dan <em>guided note taking</em> pada kelas X MAN 1 Semarang tahun pelajaran 2018/2019<em>. </em>Jenis penelitian yang digunakan adalah penelitian eksperimen dengan desain <em>quasi eksperimental</em>. Hasil skor motivasi belajar melalui metode <em>everyone is teacher here</em> yaitu 73,97 sedangkan melalui metode <em>guided note taking</em> sebesar 69,81. Sehingga dapat diketahui bahwa motivasi belajar siswa melalui metode <em>everyone is teacher here</em> lebih tinggi dibanding metode <em>guided note taking</em>. Berdasarkan analisis uji t diketahui t hitung sebesar 2.3315 dan t tabel 1,666. Sehingga dapat disimpulan Ha diterima karena thitung &gt; ttabel
PENGEMBANGAN FOUR-TIER MULTIPLE CHOICE DIAGNOSTIC TEST UNTUK MENDETEKSI PEMAHAMAN KONSEP KOGNITIF MATERI KATABOLISME PADA PESERTA DIDIK KELAS XII SMA / MA
Authors: Salamah Umi , Khasanah Nur , Hayati Nur 
Published: October 2020

Penelitian ini mengembangkan <em>Four-tier multiple choice diagnostic test</em> (tes diagnostik pilihan ganda empat tingkat) pada materi katabolisme. Penelitian ini bertujuan untuk mendeskripsikan karakteristik butir soal instumen tes diagnostik empat tingkat, dan mendeteksi pemahaman konsep kognitif yang dialami peserta didik pada materi katabolisme. Jenis penelitian ini adalah <em>Research and Development</em> <em>(R&amp;D)</em>. Subjek uji coba adalah peserta didik kelas XII IPA MAN 2 Semarang tahun ajaran 2018/2019. Metode pengambilan data yang digunakan adalah wawancara, tes, pengisian angket, dan dokumentasi. Tes diagnostik terdiri dari empat tingkat, yaitu tingkat pertama terdiri dari pertanyaan dengan satu kunci jawaban dan empat pengecoh, tingkat kedua terdiri dari tingkat keyakinan jawaban, tingkat ketiga terdiri dari pilihan alasan, dan tingkat keempat terdiri dari tingkat keyakinan alasan. Instrumen yang dihasilkan berupa kisi-kisi, petunjuk pengerjaan soal, soal tes, kunci jawaban, petunjuk pengisian lembar jawaban, lembar jawaban, pedoman penskoran, dan pedoman interpretasi hasil. Instrumen soal ini layak digunakan berdasarkan uji validasi oleh empat dosen yakni dua dosen ahli materi dan dua dosen ahli evaluasi. Instrumen yang dikembangkan sebanyak 40 butir soal. Hasil validasi menunjukkan 37 butir soal valid, dan 3 butir soal tidak valid dan semua reliabel. Reliabilitas butir soal yang dikembangkan masuk kategori tinggi yaitu sebesar 0,894. Produk akhir butir soal yang dihasilkan mempunyai jumlah 37 butir soal terdiri dari 4 butir soal mudah, 24 butir soal sedang, dan 9 butir soal susah. Butir soal yang dikembangkan juga memiliki daya beda dengan kategori 4 butir soal cukup baik dan 33 butir soal baik. sebanyak 18 indikator soal ditemukan mengalami miskonsepsi. Miskonsepsi tertinggi ditemukan pada konsep analisis peran enzim. Miskonsepsi terendah ditemukan pada konsep analisis peran ATP dan perubahan molekul saat transpor elektron dan fosforilasi oksidatif
Laparoscopic Repair of Near Complete Traumatic Duodenal Transaction in an Eight Years Old Child: A Case Report
Authors: Jan Iftikhar A. , Al Shehhi Muna Ahmed , Hassan Mokhtar Ali , Saqi Zahid Latif , Ahmad Syed Faheem 
Published: October 2020

Background:
Traumatic duodenal perforation is a serious injury and is a result of major trauma and insult to the body. The management is difficult due to
associated injuries and these children often need major resuscitation. The standard surgical treatment of traumatic duodenal perforation is
laparotomy and repair of duodenal perforation. In children, laparoscopic repair of duodenal perforation is reported in only a few cases.

Case:
A repair of a near-complete duodenal transaction is not reported in the pediatric population. Herein, we report a case of an eight years old child
who had a road traffic accident, and sustained multiple injuries and duodenal perforation, as confirmed by radiological evaluation including CT
abdomen. The child was resuscitated, and later laparoscopy was performed, which showed gross bruising of the abdominal wall and a nearcomplete
transaction at the level of 3rd part of the duodenum.

Conclusion:
Laparoscopic repair of the duodenum was performed using interrupted polyglycolic sutures. The child had a smooth post-op recovery and was
discharged home in stable condition. At one-year follow-up, the child remained well and symptom-free. This case highlights the role of the safety
of laparoscopic surgery in abdominal trauma and duodenal perforations.
Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions
Authors: Panda Mrunmaya K. , Paul Manish , Singdevsachan Sameer K. , Tayung Kumananda , Das Swagat K. , Thatoi Hrudayanath 
Published: October 2020

Background:
Nowadays medicines derived from natural sources have drawn much attention as potential therapeutic agents in the suppression and treatment of cancer because of their low toxicity and fewer side effects.

Objective:
The present review aims to assess the currently available knowledge on the ethnomedicinal
uses and pharmacological activities of bioactive compounds obtained from medicinal mushrooms towards
cancer treatment.

Methods:
A literature search has been conducted for the collection of research papers from universally
accepted scientific databases. These research papers and published book chapters were scrutinized to
retrieve information on ethnomedicinal uses of mushrooms, different factors involved in cancer cell
proliferation, clinical and in silico pharmaceutical studies made for possible treatments of cancer using
mushroom derived compounds. Overall, 241 articles were retrieved and reviewed from the year 1970
to 2020, out of which 98 relevant articles were finally considered for the preparation of this review.

Results:
This review presents an update on the natural bioactive substances derived from medicinal
mushrooms and their role in inhibiting the factors responsible for cancer cell proliferation. Along with
it, the present review also provides information on the ethnomedicinal uses, solvents used for extraction
of anti-cancer metabolites, clinical trials, and in silico studies that were undertaken towards anticancer
drug development from medicinal mushrooms.

Conclusion:
The present review provides extensive knowledge on various anti-cancer substances obtained
from medicinal mushrooms, their biological actions, and in silico drug designing approaches,
which could form a basis for the development of natural anti-cancer therapeutics.
Enantioselective Analysis of Mexiletine Using Chromatographic
Techniques: A Review
Authors: Vashistha Vinod Kumar 
Published: October 2020

Background:
Mexiletine belongs to the β-amino-aryl-ether group of pharmaceutical and applied in the diagnosis of antiarrhythmics, allodynia, and myotonic disorders. In its chemical structure, it possesses a chiral center and practiced in the form of the racemic mixture. The production and accessibility of mexiletine have accompanied with a meaningful development in awareness of its pharmacologic actions. But in clinical arrhythmias and binding experiments on cardiac sodium channels, the (R)-enantiomer of mexiletine is more potent than the (S)-enantiomer. Also, (S)-enantiomer is further active in the diagnosis of allodynia than the (R)-enantiomer.

Methods:
During the last two decades, chromatographic techniques such as HPLC, and GC coupled with mass spectrometry or field ionization detector was used for the stereoselective analysis of MEX enantiomers.

Results:
The direct enantioresolution deal with the use of chiral stationary phases (CSPs) with or no pre-derivatization which depend on a chromophoric entity in the racemates whereas indirect HPLC process involved the use of chiral derivatization reagents (CDR) for the synthesis of diastereomeric derivatives of racemates. Different techniques have their strengths and weaknesses.

Conclusion:
Regulation of enantiomeric purity and estimation of particular enantiomers of drug molecules stays an essential topic for therapeutic, diagnostic, and regulatory uses and to promote a precise assessment of the hazards to human health by false enantiomers. This review aims to offer a systematic survey of the analytical methods (chromatography based) used in the enantioselective analysis of MEX developed in the last two decades (the year 2000 onwards).
Social Economic Condition of Coastal Communities and Development Strategy of Capture Fisheries Potentials in Buleleng Regency
Authors: Negara I Ketut Wija 
Published: October 2020

The purpose of this study was to determine the socio-economic conditions of coastal communities and determine the strategy for developing fisheries potential in Buleleng Regency. This research was conducted in seven districts: Gerogak, Seririt, Banjar, Buleleng, Sawan, Kubutambahan, and Tejakula. The research method uses SWOT Analysis. The full age range of fishermen is dominated by the age of 41-50 and the education level of Elementary Schools (SD). In general the condition of the fleet and fishing gear is still classified as small-scale fishing, with an average amount of fishermen income of Rp 1,000,000-2,000,000 / month. The recommended development strategy is the SO strategy: (1) organizing marketing of fish catches by fishermen groups; (2) compile investment profile of the opportunities in capture fisheries business; (3) enhancing the role of fisheries scouts to assist fishing activities. The fishery potential in WPP 713 can be maximized through the cooperation of fishermen in the form of a Kelompok Usaha Bersama (KUB)
Music – Bodies – Machines
Authors: Rossiter Martine Louise 
Published: October 2020

This article provides an overview of the Music – Bodies – Machines: Fritz Kahn and Acousmatic Music project and accompanying suite of music – Der Industriepalast. The project is inspired by the work of infographics pioneer Fritz Kahn (1888-1968) who developed works such as Der Mensch als Industriepalast. There is a body of work examining Kahn’s work (Sappol, 2017; Von Debschitz, 2017; Doudova, Jacobs, et al.) that has revealed Kahn’s intent of making the human anatomy accessible to the non-specialised reader through visual metaphors; unlike the descriptive anatomical illustrations of the eighteenth and nineteenth centuries, which show how the human body looks, Kahn’s works visually explain how internal structures work using concepts, metaphors, and allusions.
This article explores some of the ways in which Kahn’s striking visual images have inspired the composition of five novel acousmatic works of music. The article starts with a survey of existing works making use of similar, extra-musical influences to examine how extra-musical influences such as infographics and painting may influence the formal design of acousmatic music. It goes on to consider how, exactly, the infographics of Fritz Kahn have been used within the project. In some cases, this guides the choice of particular materials (such as the sound of a beating heart to represent an image of a heart monitor), but in other cases, there is influence on phrasing, placement, and even the formal design of entire pieces.
Taken as a whole, the article seeks to explore the following questions; 1) What impact does the context of a particular image have on a composers’ response? 2) How do composers respond to visual stimuli in acousmatic music? What is their compositional process? 3) How do such parallels between the specific sonic and visual examples offer new interdisciplinary insight to artistic practices and research? 4) How do sound recording techniques inform acousmatic music and generate new creative processes that operate within the sphere of human-machine relations?
Factors Affecting Success of ERP (Enterprise Resource Planning) System Implementation
Authors: Erwanto Elyus Dwi , Zusi Hasmand 
Published: October 2020

This study aimed to determine the factors that influence the successful (critical successfactors) of ERP implementation in the company's client PT. Artsys Integrasi Solusindo. The data used are primary data using questionnaires from respondents. This research was conducted on 13 companies that have implemented ERP, with 80 respondents being used as samples. The sampling method in this study uses non-probability sampling with a quota sampling technique based on criteria. The analytical tool used in this study is regression analysis. The research hypothesis testing was completed using t-test, F-test and descriptive analysis. The results of this study indicate that Change Management, Project Management, Top Management Sponsorship, Realistic Scope Setting, and Adequate Budget are factors that influence the success of ERP implementation. While the factor of Education in an ERP project does not have a significant effect. But simultaneously, the six factors can explain the relation to the success of ERP implementation with the R-square value of 67.6%. With this research, it is expected that ERP consultants and implementers and the companies that are currently and will implement ERP to pay attention and prepare well the factors that determine the success of ERP implementation.
Effect of Liquidity, Profitability, and Sales Growth on Capital Structure (in Manufacturing Companies)
Authors: Marlina Marlina , Pinem Dahlia , Hidayat Nur Fatkhul 
Published: October 2020

Abstract - This research was conducted to examine the effect of liquidity, profitability and sales growth on capital structure. This research was conducted at manufacturing companies listed on the Indonesia Stock Exchange. The technique of determining the sample using purposive sampling method. Selection of samples from 165 manufacturing companies listed on the Indonesia Stock Exchange in 2016-2018 resulted in 33 companies being accepted. Data analysis was performed using Microsoft Excel 2013 and hypothesis testing in this research used Panel Data Regression Analysis with the E-Views 9.0 program and a significance level of 5%. The results of the test were obtained (1) the liquidity stated by CR has no significant effect on the capital structure. (2) profitability stated by ROE has a significant positive effect on capital structure, (3) sales growth stated by SG has no significant positive effect on capital structure. Keywords: liquidity, profitability, sales growth, capital structure