bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identities behind some congruences for r-Bell and derangement polynomials
Authors: Serafin Grzegorz 
Published: October 2020

AbstractWe derive new congruences bounding r-Bell and derangement polynomials, which generalize the existing ones, while the presented approach is significantly simpler and, at the same time, more informative. Namely, we provide precise identities that imply the congruences and explain somehow their nature.
Development of emotion regulation across the first two years of college
Authors: Park Crystal L. , Williams Michelle K. , Hernandez Paul R. , Agocha V. Bede , Lee Sharon Y. , Carney Lauren M. , Loomis David 
Published: October 2020

ABSTRACTIntroductionEmotion regulation is thought to develop substantially from late adolescence into early adulthood; further, the rate of development purportedly varies based on personal and contextual characteristics. However, little research has explicitly documented this maturation in young adulthood or identified its determinants. We aimed to (1) characterize how adaptive (positive reappraisal, emotional social support‐seeking) and maladaptive (suppression, substance use coping) emotion regulation strategies changed over time and (2) predict change in each strategy based on baseline personal, social, and motivational characteristics.MethodsWe followed a sample of 1578 students entering university in the northeastern United States across their first two years, assessing them four times.ResultsAs expected, social support‐seeking increased and suppression decreased. However, contrary to expectations, cognitive reappraisal declined over time while substance use coping increased. Women generally used more adaptive emotion regulation strategies than did men; social engagement and connection and eudaimonic well‐being were generally predictive of using more adaptive coping over time.ConclusionsOverall, students did not consistently demonstrate maturation to more adaptive emotion regulation and in fact exhibited decrements over the first two years of college. Students’ baseline characteristics accounted for substantial degrees of change in emotion regulation. These findings suggest potentially fruitful directions for interventions to assist college students in developing more adaptive emotion regulation skills.
Development of a fire detection and suppression system for a smart air cargo container
Authors: Zhang Q. , Wang Y.C. , Soutis C. , Gresil M. 
Published: October 2020

ABSTRACTThis study investigates and proposes a fire detection and suppression system for a smart air cargo container. A series of smoke spread and fire evolution numerical models are executed to assess the performance of container-based fire detection in various fire scenarios. This is to identify the worst case and optimise the location and threshold setting of fire detection sensors, achieving the shortest detection time. It is found that the fire detection threshold (reduction in light transmission = 12%/ft) for a container-based system can be set at three times the standard activation threshold for a cargo-based fire detection system, which can reduce the number of false alarms by three orders of magnitude. Moreover, effectiveness analysis of passive fire protection for the glass fibre-reinforced polymer-made smart container indicates an allowable leakage size of 0.01m2. The risk of internal overpressure has been found to be negligible for the leakage size required by aircraft pressure equalisation.
Toward a Corporate Duty for Lead Companies to Respect Human Rights in Their Global Value Chains?
Authors: Bright Claire , Marx Axel , Pineau Nina , Wouters Jan 
Published: October 2020

AbstractThe corporate responsibility to respect human rights was formally introduced in 2011 with the unanimous endorsement of the UN Guiding Principles on Business and Human Rights (UNGPs) by the UN Human Rights Council. It is grounded in social expectations and forms part of the companies' “social license to operate.” This paper argues that this responsibility is progressively turning into a legal duty for lead companies to respect human rights in those types of value chains which are characterized by a high level of control by a lead company over its business partners. Our argument rests on two recent legal developments. Firstly, the article analyzes the judicialization of the corporate responsibility to respect in the case law on parent company liability in various jurisdictions, which, we argue, is highly likely to have some implications in relation to certain types of value chains so as to trigger the liability of lead companies for the human rights harms arising out of the activities of entities over which they exercise sufficient control. Secondly, the article delves into the legislative developments which increasingly require lead companies to exercise due diligence so as to prevent and address adverse human rights impacts in their own activities and global value chains.
A Patient-Inspired Quality Improvement Initiative for Pituitary Adenoma Care
Authors: Druce Irena , Doyle Mary-Anne , Arnaout Amel , Liu Dora , AlKherayf Fahad , Agbi Charles , Keely Erin , Malcolm Janine 
Published: October 2020

ABSTRACT:Background:Pituitary adenomas (PAs) are common and often require complex multidisciplinary care with multiple specialists. This may result in a healthcare system that is challenging for patients to navigate. Audits of care at our institution revealed opportunities for improvement to better align care with patients’ needs.Methods:A quality improvement initiative that incorporated a patient advisory committee of patients who had received treatment for PA at our center and their family members were used to help identify opportunities for improvement. The patient-identified gaps in care included the need to coordinate and minimize appointments and the desire for better communication and education. Based on this information, changes were implemented to the pituitary program, including increasing access to the Multidisciplinary Clinic and developing a standardized and centralized triage process.Results:A pre- and post-intervention analysis consisting of retrospective chart reviews revealed that these changes had an impact on wait times for first assessment, and a significant shift in the location of this first visit – with a larger proportion of patients being seen in the Multidisciplinary Clinic after an intervention.Conclusions:We demonstrate that patient involvement, beyond individual patient–physician interactions, can lead to meaningful and observable changes, and can improve the quality of care for PA.
Freedom and Justice in Trade Governance
Authors: Goff Sarah C. 
Published: October 2020

AbstractTwo recent books consider the future of trade governance.Consent and Tradeproposes reforms to trade agreements so that states can consent more freely to their terms.On Trade Justicedefends reforms to the World Trade Organization, arguing that multilateralism is the foundation for a “new global deal” on trade. Each book describes trade's distinctive features and proposes a principle to regulate both trade and trade governance.Consent and Tradedefends a principle of respect for state consent in trade agreements.On Trade Justiceoffers a theory of trade justice that requires nonexploitation. Consent and nonexploitation are important principles for economic exchanges. However, trade governance and trade itself are different forms of cooperation, with different agents and different interests at stake. Consent and nonexploitation are less compelling as principles for trade governance than for trade itself. Both books understate the conflict between their principles for trade governance and liberal justice.
Norovirus and rotavirus in children hospitalised with diarrhoea after rotavirus vaccine introduction in Burkina Faso
Authors: Rönnelid Y. , Bonkoungou I. J. O. , Ouedraogo N. , Barro N. , Svensson L. , Nordgren J. 
Published: October 2020

Abstract
Several studies report norovirus as the new leading cause of severe gastroenteritis in children after the global introduction of rotavirus vaccines. Burkina Faso introduced general rotavirus vaccination with the oral pentavalent vaccine RotaTeq in November 2013 and quickly reached a vaccine coverage of >90%. This study describes detection rates, clinical profiles and the molecular epidemiology of norovirus and rotavirus infections in 146 children aged <5 years with severe acute gastroenteritis in Ouagadougou, consecutively enrolled from a hospital between January 2015 and December 2015. Virus detection was performed with an antigen test or real-time polymerase chain reaction (PCR) and genotyping was performed by nucleotide sequencing or multiplex PCR. Rotavirus was found in 14% and norovirus in 20% of faecal samples. Norovirus infection was significantly more associated with severe dehydration compared to rotavirus (P < 0.001). Among genotyped norovirus samples 48% (12/25) belonged to GII.4 which caused significantly more diarrhoeal episodes than non-GII.4 genotypes (P = 0.01). The most common rotavirus genotypes were G2P[4] (30%), G12P[6] (25%) and G12P[8] (20%). Fifty percent of the rotavirus positive children were infected with fully or partly heterotypic strains. In conclusion, this study found a higher proportion of norovirus causing more severe symptoms in children with diarrhoea in Burkina Faso after the introduction of rotavirus vaccination.
Distinguishing multicellular life on exoplanets by testing Earth as an exoplanet
Authors: Doughty Christopher E. , Abraham Andrew J. , Windsor James , Mommert Michael , Gowanlock Michael , Robinson Tyler , Trilling David E. 
Published: October 2020

AbstractCan multicellular life be distinguished from single cellular life on an exoplanet? We hypothesize that abundant upright photosynthetic multicellular life (trees) will cast shadows at high sun angles that will distinguish them from single cellular life and test this using Earth as an exoplanet. We first test the concept using unmanned aerial vehicles at a replica moon-landing site near Flagstaff, Arizona and show trees have both a distinctive reflectance signature (red edge) and geometric signature (shadows at high sun angles) that can distinguish them from replica moon craters. Next, we calculate reflectance signatures for Earth at several phase angles with POLDER (Polarization and Directionality of Earth's reflectance) satellite directional reflectance measurements and then reduce Earth to a single pixel. We compare Earth to other planetary bodies (Mars, the Moon, Venus and Uranus) and hypothesize that Earth's directional reflectance will be between strongly backscattering rocky bodies with no weathering (like Mars and the Moon) and cloudy bodies with more isotropic scattering (like Venus and Uranus). Our modelling results put Earth in line with strongly backscattering Mars, while our empirical results put Earth in line with more isotropic scattering Venus. We identify potential weaknesses in both the modelled and empirical results and suggest additional steps to determine whether this technique could distinguish upright multicellular life on exoplanets.
Earthquake Hazard Uncertainties Improved Using Precariously Balanced Rocks
Authors: Rood A. H. , Rood D. H. , Stirling M. W. , Madugo C. M. , Abrahamson N. A. , Wilcken K. M. , Gonzalez T. , Kottke A. , Whittaker A. C. , Page W. D. , Stafford P. J. 
Published: October 2020

AbstractProbabilistic seismic hazard analysis (PSHA) is the state‐of‐the‐art method to estimate ground motions exceeded by large, infrequent, and potentially damaging earthquakes; however, a fundamental problem is the lack of an accepted method for both quantitatively validating and refining the hazard estimates using empirical geological data. In this study, to reduce uncertainties in such hazard estimates, we present a new method that uses empirical data from precariously balanced rocks (PBRs) in coastal Central California. We calculate the probability of toppling of each PBR at defined ground‐motion levels and determine the age at which the PBRs obtained their current fragile geometries using a novel implementation of cosmogenic 10Be exposure dating. By eliminating the PSHA estimates inconsistent with at least a 5% probability of PBR survival, the mean ground‐motion estimate corresponding to the hazard level of 10−4 yr−1 (10,000 yr mean return period) is significantly reduced by 27%, and the range of estimated 5th–95th fractile ground motions is reduced by 49%. Such significant reductions in uncertainties make it possible to more reliably assess the safety and security of critical infrastructure in earthquake‐prone regions worldwide.
Thermal History of the Earth: On the Importance of Surface Processes and the Size of Tectonic Plates
Authors: Grigné C. , Combes M. 
Published: October 2020

AbstractGeochemical constraints on mantle temperature indicate a regular decrease by around 250 K since 3 Ga. However, models of Earth's cooling that rely on scaling laws for thermal convection without strong plates are facing a thermal runaway backwards in time, due to the power‐law dependence of heat loss on temperature. To explore the effect of surface dynamics on Earth's cooling rate, we build a two‐dimensional temperature‐dependent model of plate tectonics that relies on a force balance for each plate and on Earth‐like parameterized behaviors for the motion, creation, and disappearance of plate boundaries. While our model predicts the expected thermal runaway if plate boundaries are fixed, we obtain an average cooling rate consistent with geochemical estimates if the geometry of plate tectonics evolves through time. For a warmer mantle in the past, plates are faster but also larger (and less numerous) so that the average seafloor age and resulting heat flux always remain moderate. The predicted decrease in the number of plates backwards in time is in good agreement with recent plate reconstructions over the last 400 Myr. Our model also gives plate speed and subduction area flux consistent with these reconstructions. We finally compare the effect of parameters controlling mantle viscosity and individual plate speeds to the effect of localized surface processes, such as oceanization and subduction initiation. We infer that studies of Earth's thermal history should focus on surface processes as they appear to be key control parameters.
Tropical Cyclones Significantly Alleviate Mega‐Deltaic Erosion Induced by High Riverine Flow
Authors: Wang Jie , Dai Zhijun , Mei Xuefei , Fagherazzi Sergio 
Published: October 2020

AbstractThe drastic decline in sediment discharge experienced by large rivers in recent years might trigger erosion thus increasing the vulnerability of their extensive deltas. However, scarce information is available on the erosion patterns in mega‐deltas and associated physical drivers. Here a series of bathymetries in the South Passage, Changjiang Delta, were analyzed to identify morphodynamic variations during high riverine flow and tropical cyclones (TCs). Results indicate that high river flow during flood season triggers large‐scale net erosion along the inner estuary, generating elongated erosion‐deposition patches. Erosion magnitude gradually weakens moving seaward with few localized bottom variations in the offshore area. TCs transport sediment landward and are accompanied by an overall weak erosion, with a less organized spatial pattern of erosion‐deposition. TCs can therefore significantly alleviate erosion, reducing the sediment loss induced by riverine flows by over 50%. These results highlight the role of TCs on the sediment dynamics of mega‐deltas.
Modeling Evidence of QBO‐MJO Connection: A Case Study
Authors: Back Seung‐Yoon , Han Ji‐Young , Son Seok‐Woo 
Published: October 2020

AbstractThe boreal winter Madden‐Julian Oscillation (MJO) is modulated by the Quasi‐Biennial Oscillation (QBO). The MJO becomes relatively strong during the easterly QBO (EQBO) winters but weak during the westerly QBO (WQBO) winters. To better understand their relationship, a set of WRF model experiments is conducted with varying lateral boundary conditions. The MJO event in December 2007, during EQBO winter, is chosen as a reference case. The control experiment qualitatively reproduces the observed MJO. When the lateral boundary conditions are switched with those of WQBO or strong WQBO winters, the MJO becomes weak over the Maritime Continent. All eight ensemble members exhibit enhanced outgoing longwave radiation and reduced precipitation from EQBO to WQBO, and to strong WQBO conditions, although the magnitude of changes is smaller than observations. This result, one of the first mesoscale modeling evidences of the QBO‐MJO connection, suggests that the MJO is at least partly modulated by the QBO.
Multiple‐Stroke Positive Cloud‐to‐Ground Lightning Observed by the FALMA in Winter Thunderstorms in Japan
Authors: Wu Ting , Wang Daohong , Takagi Nobuyuki 
Published: October 2020

AbstractMultiple‐stroke (MS) positive cloud‐to‐ground (+CG) lightning flashes are rarely reported, especially those with high‐quality location information. In this study, we report 47 MS +CG flashes observed in winter thunderstorms in Japan with a 14‐site fast antenna lightning mapping array (FALMA). MS +CG flashes account for 18% of +CG flashes. The mean multiplicity of all +CG flashes is 1.24, and the maximum multiplicity is 5. Interstroke intervals have a very large range from 1.0 to 1,320.6 ms with the geometric mean of 64.4 ms. In three flashes, interstroke intervals smaller than 2 ms are observed, and corresponding positive strokes are inferred to be produced by two branches of the same positive leader. Horizontal distances between sequential positive strokes range from 1.1 to 37.3 km with the geometric mean of 9.7 km. No subsequent strokes struck at the same location as a previous stroke. Distances between sequential strokes are generally much larger than distances between first strokes and lightning initiation locations. Subsequent stroke peak amplitudes are on average 0.45 of first stroke peak amplitudes. In 39 flashes (83%), the first stroke is stronger than the largest subsequent stroke in the same flash. Subsequent stroke amplitudes are weakly correlated with the time difference from the previous stroke. Origination mechanisms of positive leaders initiating first and subsequent positive strokes are discussed. It is very likely that positive leaders for most subsequent strokes originate from in‐cloud negative leader channels, but origination mechanisms for positive leaders initiating first strokes are more varied.
P11 deficiency increases stress reactivity along with HPA axis and autonomic hyperresponsiveness
Authors: Sousa Vasco C. , Mantas Ioannis , Stroth Nikolas , Hager Torben , Pereira Marcela , Jiang Haitang , Jabre Sandra , Paslawski Wojciech , Stiedl Oliver , Svenningsson Per 
Published: October 2020

AbstractPatients suffering from mood disorders and anxiety commonly exhibit hypothalamic–pituitary–adrenocortical (HPA) axis and autonomic hyperresponsiveness. A wealth of data using preclinical animal models and human patient samples indicate that p11 deficiency is implicated in depression-like phenotypes. In the present study, we used p11-deficient (p11KO) mice to study potential roles of p11 in stress responsiveness. We measured stress response using behavioral, endocrine, and physiological readouts across early postnatal and adult life. Our data show that p11KO pups respond more strongly to maternal separation than wild-type pups, even though their mothers show no deficits in maternal behavior. Adult p11KO mice display hyperactivity of the HPA axis, which is paralleled by depression- and anxiety-like behaviors. p11 was found to be highly enriched in vasopressinergic cells of the paraventricular nucleus and regulates HPA hyperactivity in a V1B receptor-dependent manner. Moreover, p11KO mice display sympathetic–adrenal–medullary (SAM) axis hyperactivity, with elevated adrenal norepinephrine and epinephrine levels. Using conditional p11KO mice, we demonstrate that this SAM hyperactivity is partially regulated by the loss of p11 in serotonergic neurons of the raphe nuclei. Telemetric electrocardiogram measurements show delayed heart rate recovery in p11KO mice in response to novelty exposure and during expression of fear following auditory trace fear conditioning. Furthermore, p11KO mice have elevated basal heart rate in fear conditioning tests indicating increased autonomic responsiveness. This set of experiments provide strong and versatile evidence that p11 deficiency leads to HPA and SAM axes hyperresponsiveness along with increased stress reactivity.
Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning
Authors: Chang Miao , Womer Fay Y. , Gong Xiaohong , Chen Xi , Tang Lili , Feng Ruiqi , Dong Shuai , Duan Jia , Chen Yifan , Zhang Ran , Wang Yang , Ren Sihua , Wang Yi , Kang Jujiao , Yin Zhiyang , Wei Yange , Wei Shengnan , Jiang Xiaowei , Xu Ke , Cao Bo , Zhang Yanbo , Zhang Weixiong , Tang Yanqing , Zhang Xizhe , Wang Fei 
Published: October 2020

AbstractConverging evidence increasingly implicates shared etiologic and pathophysiological characteristics among major psychiatric disorders (MPDs), such as schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Examining the neurobiology of the psychotic-affective spectrum may greatly advance biological determination of psychiatric diagnosis, which is critical for the development of more effective treatments. In this study, ensemble clustering was developed to identify subtypes within a trans-diagnostic sample of MPDs. Whole brain amplitude of low-frequency fluctuations (ALFF) was used to extract the low-dimensional features for clustering in a total of 944 participants: 581 psychiatric patients (193 with SZ, 171 with BD, and 217 with MDD) and 363 healthy controls (HC). We identified two subtypes with differentiating patterns of functional imbalance between frontal and posterior brain regions, as compared to HC: (1) Archetypal MPDs (60% of MPDs) had increased frontal and decreased posterior ALFF, and decreased cortical thickness and white matter integrity in multiple brain regions that were associated with increased polygenic risk scores and enriched risk gene expression in brain tissues; (2) Atypical MPDs (40% of MPDs) had decreased frontal and increased posterior ALFF with no associated alterations in validity measures. Medicated Archetypal MPDs had lower symptom severity than their unmedicated counterparts; whereas medicated and unmedicated Atypical MPDs had no differences in symptom scores. Our findings suggest that frontal versus posterior functional imbalance as measured by ALFF is a novel putative trans-diagnostic biomarker differentiating subtypes of MPDs that could have implications for precision medicine.
Involvement of CsWRKY70 in salicylic acid-induced citrus fruit resistance against Penicillium digitatum
Authors: Deng Bing , Wang Wenjun , Ruan Changqing , Deng Lili , Yao Shixiang , Zeng Kaifang 
Published: October 2020

AbstractPenicillium digitatum causes serious losses in postharvest citrus fruit. Exogenous salicylic acid (SA) can induce fruit resistance against various pathogens, but the mechanism remains unclear. Herein, a transcriptome-based approach was used to investigate the underlying mechanism of SA-induced citrus fruit resistance against P. digitatum. We found that CsWRKY70 and genes related to methyl salicylate (MeSA) biosynthesis (salicylate carboxymethyltransferase, SAMT) were induced by exogenous SA. Moreover, significant MeSA accumulation was detected in the SA-treated citrus fruit. The potential involvement of CsWRKY70 in regulating CsSAMT expression in citrus fruit was studied. Subcellular localization, dual luciferase, and electrophoretic mobility shift assays and an analysis of transient expression in fruit peel revealed that the nucleus‐localized transcriptional activator CsWRKY70 can activate the CsSAMT promoter by recognizing the W-box element. Taken together, the findings from this study offer new insights into the transcriptional regulatory mechanism of exogenous SA-induced disease resistance in Citrus sinensis fruit.