bluuebunny/crossref_metadata_2025_split huggingface dataset:
VEGFR2 signaling drives meningeal vascular regeneration upon head injury
Authors: Koh Bong Ihn , Lee Hyuek Jong , Kwak Pil Ae , Yang Myung Jin , Kim Ju-Hee , Kim Hyung-Seok , Koh Gou Young , Kim Injune 
Published: July 2020

AbstractUpon severe head injury (HI), blood vessels of the meninges and brain parenchyma are inevitably damaged. While limited vascular regeneration of the injured brain has been studied extensively, our understanding of meningeal vascular regeneration following head injury is quite limited. Here, we identify key pathways governing meningeal vascular regeneration following HI. Rapid and complete vascular regeneration in the meninges is predominantly driven by VEGFR2 signaling. Substantial increase of VEGFR2 is observed in both human patients and mouse models of HI, and endothelial cell-specific deletion of Vegfr2 in the latter inhibits meningeal vascular regeneration. We further identify the facilitating, stabilizing and arresting roles of Tie2, PDGFRβ and Dll4 signaling, respectively, in meningeal vascular regeneration. Prolonged inhibition of this angiogenic process following HI compromises immunological and stromal integrity of the injured meninges. These findings establish a molecular framework for meningeal vascular regeneration after HI, and may guide development of wound healing therapeutics.
Anthropogenic climate change has driven over 5 million km2 of drylands towards desertification
Authors: Burrell A. L. , Evans J. P. , De Kauwe M. G. 
Published: July 2020

AbstractDrylands cover 41% of the earth’s land surface and include 45% of the world’s agricultural land. These regions are among the most vulnerable ecosystems to anthropogenic climate and land use change and are under threat of desertification. Understanding the roles of anthropogenic climate change, which includes the CO2 fertilization effect, and land use in driving desertification is essential for effective policy responses but remains poorly quantified with methodological differences resulting in large variations in attribution. Here, we perform the first observation-based attribution study of desertification that accounts for climate change, climate variability, CO2 fertilization as well as both the gradual and rapid ecosystem changes caused by land use. We found that, between 1982 and 2015, 6% of the world’s drylands underwent desertification driven by unsustainable land use practices compounded by anthropogenic climate change. Despite an average global greening, anthropogenic climate change has degraded 12.6% (5.43 million km2) of drylands, contributing to desertification and affecting 213 million people, 93% of who live in developing economies.
Extreme environmental conditions reduce coral reef fish biodiversity and productivity
Authors: Brandl Simon J. , Johansen Jacob L. , Casey Jordan M. , Tornabene Luke , Morais Renato A. , Burt John A. 
Published: July 2020

AbstractTropical ectotherms are hypothesized to be vulnerable to environmental changes, but cascading effects of organismal tolerances on the assembly and functioning of reef fish communities are largely unknown. Here, we examine differences in organismal traits, assemblage structure, and productivity of cryptobenthic reef fishes between the world’s hottest, most extreme coral reefs in the southern Arabian Gulf and the nearby, but more environmentally benign, Gulf of Oman. We show that assemblages in the Arabian Gulf are half as diverse and less than 25% as abundant as in the Gulf of Oman, despite comparable benthic composition and live coral cover. This pattern appears to be driven by energetic deficiencies caused by responses to environmental extremes and distinct prey resource availability rather than absolute thermal tolerances. As a consequence, production, transfer, and replenishment of biomass through cryptobenthic fish assemblages is greatly reduced on Earth’s hottest coral reefs. Extreme environmental conditions, as predicted for the end of the 21st century, could thus disrupt the community structure and productivity of a critical functional group, independent of live coral loss.
Occupational exposures and genetic susceptibility to occupational exposures are related to sickness absence in the Lifelines cohort study
Authors: Faruque Md. Omar , De Jong Kim , Vonk Judith M. , Kromhout Hans , Vermeulen Roel , Bültmann Ute , Boezen H. Marike 
Published: July 2020

AbstractIn this cross-sectional study, we investigated the association between occupational exposures and sickness absence (SA), the mediating role of respiratory symptoms, and whether genetic susceptibility to SA upon occupational exposures exists. Logistic regression was used to examine associations and structural equation modelling was used for mediation analyses. Genetic susceptibility was investigated by including interactions between occupational exposures and 11 candidate single nucleotide polymorphisms (SNPs). Biological dust, mineral dust, and pesticides exposure were associated with a lower prevalence of any SA (OR (95% CI) = 0.72 (0.58–0.89), 0.88 (0.78–0.99), and 0.70 (0.55–0.89), respectively) while gases/fumes exposure was associated with a higher prevalence of long-term SA (1.46 (1.11–1.91)). Subjects exposed to solvents and metals had a higher prevalence of any (1.14 (1.03–1.26) and 1.68 (1.26–2.24)) and long-term SA (1.26 (1.08–1.46) and 1.75 (1.15–2.67)). Chronic cough and chronic phlegm mediated the association between high gases/fumes exposure and long-term SA. Two of 11 SNPs investigated had a positive interaction with exposure on SA and one SNP negatively interacted with exposure on SA. Exposure to metals and gases/fumes showed a clear dose–response relationship with a higher prevalence of long-term SA; contrary, exposure to pesticides and biological/mineral dust showed a protective effect on any SA. Respiratory symptoms mediated the association between occupational exposures and SA. Moreover, gene-by-exposure interactions exist.
Observation of gapped state in rare-earth monopnictide HoSb
Authors: Hosen M. Mofazzel , Dhakal Gyanendra , Wang Baokai , Poudel Narayan , Singh Bahadur , Dimitri Klauss , Kabir Firoza , Sims Christopher , Regmi Sabin , Neff William , Sarkar Anan Bari , Agarwal Amit , Murray Daniel , Weickert Franziska , Gofryk Krzysztof , Pavlosiuk Orest , Wiśniewski Piotr , Kaczorowski Dariusz , Bansil Arun , Neupane Madhab 
Published: July 2020

AbstractThe rare-earth monopnictide family is attracting an intense current interest driven by its unusual extreme magnetoresistance (XMR) property and the potential presence of topologically non-trivial surface states. The experimental observation of non-trivial surface states in this family of materials are not ubiquitous. Here, using high-resolution angle-resolved photoemission spectroscopy, magnetotransport, and parallel first-principles modeling, we examine the nature of electronic states in HoSb. Although we find the presence of bulk band gaps at the $$\Gamma$$
Γ
and X-symmetry points of the Brillouin zone, we do not find these gaps to exhibit band inversion so that HoSb does not host a Dirac semimetal state. Our magnetotransport measurements indicate that HoSb can be characterized as a correlated nearly-complete electron-hole-compensated semimetal. Our analysis reveals that the nearly perfect electron-hole compensation could drive the appearance of non-saturating XMR effect in HoSb.
A non-pharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome
Authors: Greco Carolina Magdalen , Garetto Stefano , Montellier Emilie , Liu Yu , Chen Siwei , Baldi Pierre , Sassone-Corsi Paolo , Lucci Jacopo 
Published: July 2020

AbstractMetabolic syndrome has increased at a worrisome level. Lifestyle changes are not sufficient to prevent and improve the adverse effects of obesity, thus novel interventions are necessary. The aim of this study was to investigate the use and metabolic outcomes of a non-pharmacological intervention in a high-fat diet (HFD) fed mouse model, capable of recapitulating key aspects of metabolic syndrome. We show that Policaptil Gel Retard has remarkable, beneficial effects on metabolic dysfunction caused by consumption of HFD. We describe the mechanism by which such effects are obtained, highlighting the fact that the amelioration of metabolic function observed upon Policaptil Gel Retard administration is profound and of systemic nature, despite being originated by sequestering, therefore non-pharmacological events elicited in the gut lumen.
Rapid counting and spectral sorting of live coral larvae using large-particle flow cytometry
Authors: Randall Carly J. , Speaks Justin E. , Lager Claire , Hagedorn Mary , Llewellyn Lyndon , Pulak Rock , Thompson Julia , Bay Line K. , Mead David , Heyward Andrew J. , Negri Andrew P. 
Published: July 2020

AbstractResearch with coral embryos and larvae often requires laborious manual counting and sorting of individual specimens, usually via microscopy. Because many coral species spawn only once per year during a narrow temporal window, sample processing is a time-limiting step for research on the early life-history stages of corals. Flow cytometry, an automated technique for measuring and sorting particles, cells, and cell-clusters, is a potential solution to this bottleneck. Yet most flow cytometers do not accommodate live organisms of the size of most coral embryos (> 250 µm), and sample processing is often destructive. Here we tested the ability of a large-particle flow cytometer with a gentle pneumatic sorting mechanism to process and spectrally sort live and preservedMontipora capitatacoral embryos and larvae. Average survival rates of mechanically-sorted larvae were over 90% and were comparable to those achieved by careful hand-sorting. Preserved eggs and embryos remained intact throughout the sorting process and were successfully sorted based on real-time size and fluorescence detection. In-line bright-field microscopy images were captured for each sample object as it passed through the flow-cell, enabling the identification of early-stage embryos (2-cell to morula stage). Samples were counted and sorted at an average rate of 4 s larva−1and as high as 0.2 s larva−1for high-density samples. Results presented here suggest that large-particle flow cytometry has the potential to significantly increase efficiency and accuracy of data collection and sample processing during time-limited coral spawning events, facilitating larger-scale and higher-replication studies with an expanded number of species.
Battery-free fully integrated microfluidic light source for portable lab-on-a-chip applications
Authors: Storti Filippo , Bonfadini Silvio , Criante Luigino 
Published: July 2020

AbstractIntegrating a light source inside a Lab-on-a-Chip (LOC) platform has always been as challenging as much as an appealing task. Besides the manufacturing issues, one of the most limiting aspects is due to the need for an energy source to feed the light emission. A solution independent of external energy sources can be given by Chemiluminescence (CL): a well-known chemical phenomenon in which light emission is achieved because of a chemical reaction. Here we present the fabrication and the characterization of a chemiluminescent light source, fully integrated on a microfluidic platform by means of the direct writing technique known as Femtosecond Laser Micromachining. The key advantage is the possibility to insert within LOC devices light sources with complete placement freedom in 3D, wide flexibility of the emitting source geometry and no external feeding energy. The characterization is carried out by investigating the effect of confining a chemiluminescent rubrene-based reaction in small volumes and the inject pressures impact on the emission spectra. Moreover, exploiting microfluidics principles, it’s possible to move from the typical flash-type CL emission to a prolonged one (several hours). This allows to disengage bulky, external light sources, adding an extra step on the road to real device portability.
Nano-structured glaucoma drainage implant safely and significantly reduces intraocular pressure in rabbits via post-operative outflow modulation
Authors: Parikh Kunal S. , Josyula Aditya , Omiadze Revaz , Ahn Ju Young , Ha Youlim , Ensign Laura M. , Hanes Justin , Pitha Ian 
Published: July 2020

AbstractGlaucoma is a leading cause of irreversible vision loss predicted to affect more than 100 million people by 2040. Intraocular pressure (IOP) reduction prevents development of glaucoma and vision loss from glaucoma. Glaucoma surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wall of the eye (trabeculectomy) or a glaucoma drainage implant (GDI), but surgeries lose efficacy overtime, and the five-year failure rates for trabeculectomy and tube shunts are 25–45%. The majority of surgical failures occur due to fibrosis around the vent. Alternatively, surgical procedures can shunt aqueous humor too well, leading to hypotony. Electrospinning is an appealing manufacturing platform for GDIs, as it allows for incorporation of biocompatible polymers into nano- or micro-fibers that can be configured into devices of myriad combinations of dimensions and conformations. Here, small-lumen, nano-structured glaucoma shunts were manufactured with or without a degradable inner core designed to modulate aqueous humor outflow to provide immediate IOP reduction, prevent post-operative hypotony, and potentially offer significant, long-term IOP reduction. Nano-structured shunts were durable, leak-proof, and demonstrated biocompatibility and patency in rabbit eyes. Importantly, both designs prevented hypotony and significantly reduced IOP for 27 days in normotensive rabbits, demonstrating potential for clinical utility.
Proteomic analysis identifies plasma correlates of remote ischemic conditioning in the context of experimental traumatic brain injury
Authors: Saber Maha , Pathak Khyati V. , McGilvrey Marissa , Garcia-Mansfield Krystine , Harrison Jordan L. , Rowe Rachel K. , Lifshitz Jonathan , Pirrotte Patrick 
Published: July 2020

AbstractRemote ischemic conditioning (RIC), transient restriction and recirculation of blood flow to a limb after traumatic brain injury (TBI), can modify levels of pathology-associated circulating protein. This study sought to identify TBI-induced molecular alterations in plasma and whether RIC would modulate protein and metabolite levels at 24 h after diffuse TBI. Adult male C57BL/6 mice received diffuse TBI by midline fluid percussion or were sham-injured. Mice were assigned to treatment groups 1 h after recovery of righting reflex: sham, TBI, sham RIC, TBI RIC. Nine plasma metabolites were significantly lower post-TBI (six amino acids, two acylcarnitines, one carnosine). RIC intervention returned metabolites to sham levels. Using proteomics analysis, twenty-four putative protein markers for TBI and RIC were identified. After application of Benjamini–Hochberg correction, actin, alpha 1, skeletal muscle (ACTA1) was found to be significantly increased in TBI compared to both sham groups and TBI RIC. Thus, identified metabolites and proteins provide potential biomarkers for TBI and therapeutic RIC in order to monitor disease progression and therapeutic efficacy.
Scalable lateral heterojunction by chemical doping of 2D TMD thin films
Authors: Chamlagain Bhim , Withanage Sajeevi S. , Johnston Ammon C. , Khondaker Saiful I. 
Published: July 2020

AbstractScalable heterojunctions based on two-dimensional transitional metal dichalcogenides are of great importance for their applications in the next generation of electronic and optoelectronic devices. However, reliable techniques for the fabrication of such heterojunctions are still at its infancy. Here we demonstrate a simple technique for the scalable fabrication of lateral heterojunctions via selective chemical doping of TMD thin films. We demonstrate that the resistance of large area MoS2 and MoSe2 thin film, prepared via low pressure chalcogenation of molybdenum film, decreases by up to two orders of magnitude upon doping using benzyl viologen (BV) molecule. X-ray photoelectron spectroscopy (XPS) measurements confirms n-doping of the films by BV molecules. Since thin films of MoS2 and MoSe2 are typically more resistive than their exfoliated and co-evaporation based CVD counterparts, the decrease in resistance by BV doping represents a significant step in the utilization of these samples in electronic devices. Using selective BV doping, we simultaneously fabricated many lateral heterojunctions in 1 cm2 MoS2 and 1 cm2 MoSe2 films. The electrical transport measurements performed across the heterojunctions exhibit current rectification behavior due to a band offset created between the doped and undoped regions of the material. Almost 84% of the fabricated devices showed rectification behavior demonstrating the scalability of this technique.
A Novel Endosurgical Prosthesis to Treat Thoracoabdominal Aortic Aneurysm in Complex Anatomy or Emergency Settings
Authors: Saitto Guglielmo , Scafuri Antonio , Kuci Saimir , Ibrahimi Alfred , Zeitani Jacob 
Published: July 2020

Abstract
Background Despite improvements in operative techniques, open thoracoabdominal aortic aneurysm (TAAA) repair is complex and characterized by high mortality and morbidity rate. Less invasive techniques have been developed since 2005 for the treatment of TAAA. Unfortunately, many of these devices require custom fabrication, resulting in delay of many weeks until treatment can be delivered but crucial in critical emergency cases. We present a novel hybrid endovascular and surgical prosthesis, which was tested on five pigs, with the aim of reducing the barrier issues of endovascular therapy in such particular cases.
Methods The principal characteristic of the proposed hybrid endovascular prosthesis is to combine a proximal and distal stented zones and, in between, a classical surgical blood tied Dacron prosthesis. The device was tested in five pigs where feasibility of implantation and acute postoperative outcomes were evaluated, including bleeding, bowel ischemia, renal function, and peripheral blood perfusion.
Results In all cases, following laparotomy, the endoprosthesis was successfully implanted under fluoroscopy and the surgical prosthesis zone could be easily detected by the radio-opaque markers. No major bleeding or cardiac events occurred throughout preparation and implantation. One hour after prosthesis implantation and surgical anastomoses of all vessels were completed, normal urine output was registered, and no acidosis was detected.
Conclusions This novel graft has shown ease of endoprosthesis and visceral vessels implantation without the need of thoracotomy or extracorporeal circulation and may be useful in an emergency setting or high risk and complex anatomy TAAA unsuitable for traditional endovascular aneurysm repair, or to avoid an excess waiting time for a “custom made” prosthesis. The great adaptability of this “hybrid” prosthesis in complex anatomy for the majority of TAAA could be important in high-risk patients and in some difficult situations, such as a high risk of imminent rupture.
Time-Enhancement Curve of Four-Dimensional Computed Tomography Predicts Aneurysm Enlargement with Type-II Endoleak after Endovascular Aneurysm Repair
Authors: Nishihara Yunosuke , Mitsui Kota , Azama Shinya , Okamoto Daisuke , Sato Manabu , Naito Kozo , Aibe Hitoshi 
Published: July 2020

Abstract
Objective We investigated the hemodynamic features of Type-II endoleaks after endovascular aneurysm repair (EVAR) using four-dimensional (4D) computed tomography (CT) to identify patients with aneurysm enlargement.
Methods During a 13-month period (January 2017–January 2018) at our institution, we performed 4D-CT examinations in 13 patients after EVAR because of suspected Type-II endoleaks. Three patients were excluded from the study because of other endoleaks or absence of detectable endoleaks. The ramaining 10 patients were divided into two groups: enlargement group (n = 4), in which the aneurysm volume increased, and stable group (n = 6), in which the aneurysm remained stable or shrank. A CT scanner and three-dimensional workstation were used. All images were obtained using a consistent protocol (22 phase scans using the test bolus tracking method). We analyzed the hemodynamics of the endoleak cavity (EC) relative to those of the aorta and evaluated the time-enhancement curves (TECs) using measurement protocols. The strengths of correlations between these factors in the two groups were analyzed statistically.
Results TECs in the enlargement group showed a more gradual curve, and the upslope, the gradient of TEC in the ascending phase and the upslope index were significantly more gradual than those in the stable group (p = 0.0247, 0.0243). The EC washout and the EC washout index were also more gradual than in the stable group's (p = 0.019, 0.019). The enhancement duration was longer in the former than in the latter (80%, p = 0.0195; 70%, p = 0.0159; 60%, p = 0.0159). The CT number in the equilibrium phase was larger in the enlargement group than in the stable group (p = 0.019).
Conclusion The 4D-CT is useful for predicting aneurysm enlargement with Type-II endoleaks after EVAR.
Lymphatic Anatomy and Physiology
Authors: Goswami Abhishek K. , Khaja Minhaj S. , Downing Trevor , Kokabi Nima , Saad Wael E. , Majdalany Bill S. 
Published: July 2020

AbstractLymphatics have long been overshadowed by the remainder of the circulatory system. Historically, lymphatics were difficult to study because of their small and indistinct vessels, colorless fluid contents, and limited effective interventions. However, the past several decades have brought increased funding, advanced imaging technologies, and novel interventional techniques to the field. Understanding the history of lymphatic anatomy and physiology is vital to further realize the role lymphatics play in most major disease pathologies and innovate interventional solutions for them.
A Diffuse Leptomeningeal Glioneural Tumor Case Producing Hydrocephalus and Polyradiculopathy
Authors: Picarelli Helder , Nepomuceno Thales Bhering , Ribeiro Renan Ribeiro , Yamaki Vitor Nagai , Figueiredo Eberval Gadelha 
Published: July 2020

AbstractThe present report describes the case of a male 17-year-old patient who progressively developed a hydrocephalus and polyradiculopathy due to involvement of central nervous system (CNS) by a diffuse leptomeningeal glioneuronal tumor (DLGNT). The tumor had partial remission in response to the treatment with radiotherapy plus procarbazine, lomustine, and vincristine (PCV) chemotherapy, and the patient had improvement in function and pain levels. The current knowledge about DLGNT, including its clinical manifestations, imaging findings, histological characteristics, and treatment are revised and discussed in the present paper.
Adult Nasoethmoidal Encephalocele Corrected by Supraorbitary Approach: Case Report and Review
Authors: Teixeira Francisco Fernando Dacier , Aprígio Raysa Moreira , de Moraes Dionei Freitas , Góes Mário José , Chaddad-Neto Feres , Caramanti Ricardo Lourenço 
Published: July 2020

AbstractEncephalocele is a protrusion of the central nervous system elements through a defect in the dura mater and in the cranium. The prevalence of encephalocele ranges from 0.08 to 0.5 per 1,000 births. The posterior encephaloceles are more common in North America and Europe, while frontal defect is frequently found in Asia. The present paper describes a 26-year-old male patient presenting with cerebrospinal fluid leak and meningitis symptoms. He was diagnosed with congenital nasoethmoidal encephalocele and treated surgically using a supraorbital approach without complications.