bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building back better education systems: equity and COVID-19
Authors: Chapman Christopher , Bell Irene 
Published: October 2020

PurposeThe purpose of this article is to explore the relationship between the COVID-19 pandemic and the potential to use this challenging global context as an opportunity to build back better and more equitable educations systems.Design/methodology/approachThe approach taken involves drawing on the emerging literature to explore the relationship between COVID-19 and educational equity.FindingsThe analysis undertaken involves the presentation of a typology framed by the quality of educational offer and the opportunity for engagement in the offer accompanied by four reflective questions for further consideration.Originality/valueThe analysis presented here underpins the presentation of a heuristic typology designed to stimulate exploration and discussion relating to building back better, more equitable education systems after the COVID-19 pandemic.
Labors of love: service employees on customer participation
Authors: Choi Laee , Lawry Charles A. 
Published: October 2020

PurposeVery few studies have considered how customer participation (CP) influences service employees' well-being. CP may lead employees to engage in emotional labor strategies (surface/deep acting), which can elevate their job stress. Whereas surface acting involves falsifying emotions, deep acting involves empathizing with others. Therefore, the current article examines how these emotional labor strategies arise from CP and create job stress.Design/methodology/approachStudy 1 is an online survey of service employees' wellbeing during CP (n = 509). Study 2 compares service employees' responses within hedonic and utilitarian service settings through a scenario-based experiment (n = 440). PROCESS was used to analyze the data in both studies.FindingsFirst, study 1 supports that perceived CP increases job stress. Secondly, surface acting mediates the link between CP and job stress, but deep acting does not. Thereafter, Study 2 shows that the link between CP and job stress decreases as employee-customer identification (ECI) increases only during surface acting. Additionally, the impact of surface acting on job stress during CP is greater for hedonic services than utilitarian services, but there is no significant difference for deep acting.Originality/valueThis article contributes an original perspective by comparing models of service employees' responses to CP and job stress in hedonic versus utilitarian settings. Moreover, the intervening effects of ECI and emotional labor strategies on job stress, as demonstrated through these employee-facing models, offer added value to the CRM and co-creation literature.
Are you talkin' to me?: the role of culture in crisis management sensemaking
Authors: Sherman W. Scott , Roberto Katherine J. 
Published: October 2020

PurposeThis paper considers the role of culture in crisis management narratives. The importance of sensemaking and sense-giving to crisis management is expanded by exploring how understanding organization culture may affect the plausibility of sense-giving narratives in crises.Design/methodology/approachThe crisis management, sensemaking, sense-giving and organizational culture literature studies are briefly reviewed. The paper then explores how plausibility may be dependent on organizational culture and how different cultures may create different dependencies. Propositions are developed and the potential organizational interventions based on these propositions in the action research tradition are offered, as they are potential practical and research implications.FindingsOrganizational cultures as shared sensemaking mechanisms provide leaders with the framework for constructing crisis management messages. A plausible message must resonate within the shared cultural experiences of members to shape and direct behaviors during a crisis while maintaining necessary flexibility to evolve as the crisis progresses.Research limitations/implicationsPotential avenues of future research include empirically testing the effects of cultural alignment on crisis management messaging employing action research or other methods, how strength of culture affects the process and the malleability of plausibility.Practical implicationsPractical implications include an organization's understanding of how culture affects not only the messages sent but also how employees might receive the sense-giving narratives. The paper also highlights the importance of flexibility in sense-giving narratives to allow evolution of the message as the crisis changes. Additional practical implications are provided.Originality/valueThis manuscript considers the role of culture in crisis management sense-giving narratives, a topic that has received little research attention. The manuscript argues that aligning the narrative within the organization's shared cultural understanding will increase employee acceptance and adherence to the message. The paper further discusses the importance of flexibility in the sense-giving narratives as the crisis changes.
Design-based learning to enhance absorptive capacity for open innovation: the case of 3D Tune-In
Authors: Simeone Luca , Secundo Giustina , Messeni Petruzzelli Antonio , Schiuma Giovanni 
Published: October 2020

PurposeThis paper explores how learning processes supported by intensive use of design can favour absorptive capacity in open innovation contexts characterised by the interaction of a high number of diverse stakeholders.Design/methodology/approachThe paper combines the insights from theory with the empirical evidence gathered by adopting a case study approach.FindingsFindings provide evidence about the role of design-based learning to facilitate intra- and inter-organisational knowledge flows and to sustain absorptive capacity through processes of recognition, internalisation and adoption.Research limitations/implicationsThe study integrates currently distinct research streams focussing on (1) design research, particularly on how design can support knowledge processes and specific learning processes and (2) open innovation, particularly regarding how to enhance absorptive capacity in those contexts in which a high number of diverse stakeholders interact.Practical implicationsThis study can help companies, research institutions and other organisations leveraging open innovation to reflect on the potential of design-based learning processes and on how to deliberately facilitate such processes in their projects.Originality/valueThe original contribution provided by this study is to explore open innovation through some analytical categories elaborated in design research concerning materially grounded forms of design-based learning. In particular, the study investigates how design supports knowledge transfer, sharing, translation and creation.
Impact of wholesale price discrimination by the manufacturer on the profit of supply chain members
Authors: TM Rofin , Mahanty Biswajit 
Published: October 2020

PurposeThe purpose of this paper is to investigate the impact of wholesale price discrimination by a manufacturer in a retailer–e-tailer dual-channel supply chain for different product categories based on their online channel preference.Design/methodology/approachThis paper considers a dual-channel supply chain comprising of a retailer and an e-tailer engaged in competition. Game-theoretic models are developed to model the competition between the retailer and e-tailer and to derive their optimal price, optimal order quantity and optimal profit under (1) equal wholesale price strategy and (2) discriminatory wholesale price strategy. Further, a numerical example was employed to quantify the results and to capture the variation with respect to online channel preference of the product.FindingsIt is beneficial for the manufacturer to adopt a discriminatory wholesale price strategy for products having both high online channel preference and low online channel preference. However, equal wholesale price strategy is beneficial for the e-tailer and the retailer in the case of products having high online channel preference and in the case of products having low online channel preference, respectively.Practical implicationsThe study helps the manufacturers to maximize their profit by adopting the right wholesale price strategy considering the online channel preference of the product when the manufacturers are supplying to heterogeneous retailers.Originality/valueThere is scant literature on the wholesale price strategy of the manufacturer considering the heterogeneous downstream retailers. This paper contributes the literature by bridging this gap. In addition, the study establishes a link between the wholesale price strategy and online channel preference of the product.
Cucurbitacin IIb improved active chromatin‐induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells
Authors: Wu Dongke , Dong Dasheng , Bi Xiongjie , Liu Yuping , Ma Yunqing 
Published: October 2020

AbstractThe pathogenesis of systemic lupus erythematosus (SLE) is closely associated with aberrant immune system. Here, the aim of our study was to explore the regulation of cucurbitacin IIb (CuIIb) to Th17/Treg cells in SLE. Compared with normal mice, the percentage of Treg cells was downregulated in SLE mouse model, and Th17 was upregulated. Meantime, the production of Treg‐related transcription factor (foxp3) in SLE model mouse was reduced, and the production of Th17‐related transcription factor (RORγt) was increased. After treatment with CuIIb, the percentage of Treg cells in SLE mice was partly upregulated, and Th17 cells percentage was downregulated. The expression of foxp3 and RORγt in SLE mice were promoted and inhibited by CuIIb treatment, respectively. SLE‐induced kidney injury also was improved by CuIIb treatment. In vitro, we demonstrated again that CuIIb upregulated the percentage of Treg cells in lymphocytes from SLE mice, and downregulated the percentage of Th17 cells. Highly expressed IL‐6 and IL17, and lowly expressed IL‐10 and TGF‐β in lymphocytes from SLE mice were repressed and facilitated by CuIIb treatment, respectively. Overall, our data proved that CuIIb improved kidney injury in SLE mice through balancing the percentage of Th17 and Treg cells. Our data provided a reliable evidence to support the potential of CuIIb in SLE treatment.
Populists and Referendums in Europe: Dispelling the Myth
Authors: Gherghina Sergiu , Silagadze Nanuli 
Published: October 2020

AbstractMany researchers, journalists and politicians are inclined to connect populism and referendums. While in theory the two rest on similar principles, in practice this is not the case. This article shows that populist political elites make limited use of referendums compared both to their rhetoric and to non‐populists. Our findings indicate that the use of referendums is not a reflection of populist politics. They also illustrate how populists may initiate referendums strategically, and they win them quite often. The analysis draws on all sixty‐four national level referendums in Europe initiated by political elites between 2000 and 2019.
Line manager implementation and employee HR attributions mediating mechanisms in the HRM system—Organizational performance relationship: A multilevel and multipath study
Authors: Katou Anastasia A. , Budhwar Pawan S. , Patel Charmi 
Published: October 2020

AbstractDrawing on the attribution and social exchange theories, this study by proposing an integrated multilevel and multipath framework examines the impact of HRM content on organizational performance, through the serially mediating mechanisms of HR strength, line manager HR implementation, and employee HR attributions. Using a sample of 158 Greek private organizations and having data from senior managers, line managers, and employees, we conducted a multilevel path analyses via Mplus. We found that between organizations (a) HR strength fully mediates the relationship between HRM content and line manager HR implementation, (b) line manager HR implementation fully mediates the relationship between HR strength and employee HR attributions, and (c) employee HR attributions fully mediate the relationship between line manager HR implementation and organizational performance. Accordingly, this study advances prior knowledge by examining an integrated research pathways framework that has largely been investigated in isolation.
Risk factors for overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt creation in patients with liver cirrhosis
Authors: Tong Huan , Gan Can , Wei Bo , Wang Zhi Dong , Li Xiao Dan , Qian Shuai Jie , Huan Hui , Zhang Lin Hao , Yang Zhu , Chen Yi Long , Gu Yong Hong , Chen Liu Xiang , Yang Yu Hang , Wu Hao , Tang Cheng Wei 
Published: October 2020

ObjectiveThis study aimed to determine the risk factors and establish a risk score for post‐transjugular intrahepatic portosystemic shunt (TIPS) overt hepatic encephalopathy (OHE).MethodsAltogether 299 and 62 cirrhotic patients receiving TIPS from January 2015 to March 2018 were divided into the derivation and validation cohorts, respectively. The data of the derivation cohort were analyzed for risk factors of post‐TIPS OHE. A risk score was established from the derivation cohort and verified by the validation cohort.ResultsDuring a median follow‐up of 112.6 weeks, 52 (17.4%) patients in the derivation cohort experienced post‐TIPS OHE. Logistic regression showed that alcoholic cirrhosis (odds ratio [OR] 3.068, 95% confidence interval [CI] 1.423‐6.613, P = 0.004), stent diameter of 10 mm (OR 12.046 [95% CI 2.308‐62.862], P = 0.003), portal pressure gradient (PPG) decrement ≥60% (OR 3.548 [95% CI 1.741‐7.230], P < 0.001), model for end‐stage liver disease (MELD) score ≥10 (OR 2.695 [95% CI 1.203‐6.035], P = 0.016), blood ammonia (OR 1.009 [95% CI 1.000‐1.018], P = 0.043) and notable hydrothorax (OR 4.393 [95% CI 1.554‐12.415], P = 0.005) were associated with an increased risk of post‐TIPS OHE. The risk score reached a promising risk evaluation of post‐TIPS OHE when verified by the validation cohort (sensitivity 71.4%, specificity 70.7%, accuracy 71.0%).ConclusionsAlcoholic cirrhosis and notable hydrothorax are independent risk factors for post‐TIPS OHE in liver cirrhosis, together with the stent diameter of 10 mm, PPG decrement ≥60%, MELD score ≥10 and blood ammonia. The established risk score is reliable to identify high‐risk individuals of developing post‐TIPS OHE.
Endoscopic treatment of gastric antral vascular ectasia in real‐life settings: Argon plasma coagulation or endoscopic band ligation?
Authors: Fábián Anna , Bor Renáta , Szabó Ella , Kardos Viktor , Bálint Anita , Farkas Klaudia , Milassin Ágnes , Rutka Mariann , Szántó Kata , Molnár Tamás , Szűcs Mónika , Lőrinczy Katalin , Orbán‐Szilágyi Ákos , Gyökeres Tibor , Gyimesi György , Szepes Attila , Kovács Valéria , Rácz István , Szepes Zoltán 
Published: October 2020

ObjectiveThe efficacy of argon plasma coagulation (APC) on gastric antral vascular ectasia (GAVE) may be impaired over time and depends greatly on the application settings. Endoscopic band ligation (EBL) may be an alternative, but study on its efficacy is limited. This study aimed to evaluate and compare the clinical efficacy of APC and EBL in treating GAVE.MethodsChanges in the need for blood transfusion, number of treatment sessions and hospitalizations were retrospectively assessed in 63 transfusion‐dependent patients with GAVE (mean age: 67.1 y, 54.0% female) treated with either APC or EBL (45 and 18 patients, respectively) in four tertiary endoscopic centers.ResultsBoth methods substantially increased hemoglobin levels and decreased patients' need for a transfusion (22.0 ± 4.0 g/L and −5.62 ± 2.30 units of packed red blood cells [RBC] with APC, and 27.4 ± 6.1 g/L and −4.79 ± 2.46 units of packed RBC with EBL), without a significant statistical difference between the methods. However, fewer EBL sessions were required both for the cessation of need for a transfusion compared with those for the resolution of GAVE lesions (0.90 ± 0.10 vs 1.69 ± 0.31, P = 0.028).ConclusionsBoth APC and EBL are effective in GAVE treatment. EBL may be superior in terms of number of treatment sessions, but not in its influence on hemoglobin level and need for transfusion. Further prospective studies with large, homogeneous sample size and standardized APC settings are needed.
The strategy and efficacy of prophylaxis against hepatitis B virus recurrence after liver transplantation for HBV‐related diseases in the era of potent nucleos(t)ide analogues: A meta‐analysis
Authors: Li Ming Shu , Hou Zhou Hua , Yao Guo Zhu , Tan De Ming 
Published: October 2020

ObjectivesThis meta‐analysis aimed to evaluate the clinical outcome of liver transplant (LT) recipients under potent nucleoside or nucleotide analogue (NA)‐based regimens and investigate different prophylactic schemes.MethodsWe followed PRISMA statement to conduct this study. Two reviewers independently searched relevant literature via PubMed, Embase, Ovid MEDLINE, Web of Science and Insightmeme. Studies were included if they evaluated hepatitis B virus (HBV) recurrence under potent NA‐based regimens in patients who received HBV‐related LT. Primary and secondary outcomes were HBV recurrence, hepatocellular carcinoma (HCC) recurrence, all‐cause and HBV recurrence‐related mortality. Incidences with 95% confidence intervals were calculated and assessed by fixed and random effects models. Subgroup analyses were used to examine the impact of different treatment strategies.ResultsAltogether 25 studies (N = 2327) were included, with a pooled HBV recurrence rate of 1.01% (95% CI 0.53%‐1.59%). HBV viremia or hepatitis D virus superinfection did not influence HBV recurrence significantly (P = 0.23 and 0.71, respectively). The recurrence rate under an indefinite combination of potent NA and hepatitis B immunoglobulin (HBIG) was lower than that under potent NA monotherapy (P = 0.000) and similar to that under NA plus a finite course of HBIG (P = 0.48). The pooled HCC recurrence rate was 5.34% (95% CI 0.78%‐12.48%). HBV recurrence‐related mortality and all‐cause mortality were 0% and 6.95% (95% CI 4.30%‐10.08%), respectively.ConclusionsPotent NA‐based regimens provide satisfactory HBV antiviral prophylaxis and improve long‐term outcomes for LT recipients. A finite combination of potent NA and HBIG is an alternative to life‐long dual therapy.
Spotlight on microRNAs in allergy and asthma
Authors: Weidner Julie , Bartel Sabine , Kılıç Ayse , Zissler Ulrich M. , Renz Harald , Schwarze Jürgen , Schmidt‐Weber Carsten B. , Maes Tania , Rebane Ana , Krauss‐Etschmann Susanne , Rådinger Madeleine 
Published: October 2020

AbstractIn past 10 years, microRNAs (miRNAs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases and their potential as biomarkers in liquid biopsies. They act as master post‐transcriptional regulators that control most cellular processes. As one miRNA can target several mRNAs, often within the same pathway, dysregulated expression of miRNAs may alter particular cellular responses and contribute, or lead, to the development of various diseases. In this review, we give an overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma. Specifically, we discuss how individual miRNAs function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses. In addition, we review insights obtained from experiments with murine models of allergic airway and skin inflammation and offer an overview of studies focusing on miRNA discovery using profiling techniques and bioinformatic modeling of the network effect of multiple miRNAs. In conclusion, we highlight the importance of research into miRNA function in allergy and asthma to improve our knowledge of the molecular mechanisms involved in the pathogenesis of this heterogeneous group of diseases.
Centralized standards and local taxation in municipal waste management
Authors: Di Liddo Giuseppe , Vinella Annalisa 
Published: October 2020

AbstractIn the EU, standards for municipal waste sorting and recycling are established by the European central institutions, being mostly based on the available estimates of recyclable materials. In a simple model of co‐production in municipal waste management with local taxation, we assess that central bodies enjoy more discretion and can set more ambitious targets in jurisdictions with stronger environmental preferences and/or lower expenditure needs. Incentives to engage in waste sorting and recycling are found to be less powerful with citizens who are less sensitive to the environmental preservation, and all the more when the public input has a high cost. This points to the conclusion that standards should be differentiated across jurisdictions, with due consideration of the local preferences and costs of waste management.
Methyl Palmitate—A suitable adjuvant for Sorafenib therapy to reduce in vivo toxicity and to enhance anti‐cancer effects on hepatocellular carcinoma cells
Authors: Breeta Raja David Isac Evangeline , Grace Viswanathan Mariammal Berlin , Wilson Devarajan David 
Published: October 2020

AbstractThis study focused on evaluating the potency of Methyl Palmitate in reducing in vivo toxicity with enhancement of anti‐cancer effects of Sorafenib. In vitro anti‐cancer effects on human Hep‐G2 cell line were analysed by MTT, Trypan blue, clonogenic, wound scratch migration and TUNEL assays. An in vivo study for anti‐angiogenesis effect, toxicity and teratogenicity was analysed in Zebrafish embryos. The combination of Sorafenib (4.5 µmol/L) with Methyl Palmitate (3 mmol/L) significantly enhanced anti‐cancer effects on Hep‐G2 cell line by increasing cytotoxicity (P ≤ .05 in MTT assay; P ≤ .01 in Trypan blue assay), apoptosis (P ≤ .05) and decreasing the metastatic migration (P ≤ .01) than Sorafenib alone treatment. A prominent inhibition of angiogenesis in vivo was observed for combination treatment. At 5 dpf, only <20% toxicity was observed for 3 mmol/L Methyl palmitate while it was 65.75% for Sorafenib treatment which implies that it is a safer dose for in vivo treatments. A highly significant (P ≤ .001) reduction (43.20%) in toxicity was observed in combination treatment. Thus, the Sorafenib‐Methyl Palmitate combination showed a promising treatment effect with significantly reduced in vivo toxicity when compared with Sorafenib alone treatment, and hence the Methyl Palmitate may serve as a good adjuvant for Sorafenib therapy.