bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational morphogenesis of free‐form grid structures with Voronoi diagram
Authors: Su Yan , Wu Yue , Ji Wei , Sun Xiaoying 
Published: September 2020

AbstractFree‐form grid structures have developed increasingly with the development of computer‐aided design and advanced construction technology. However, the grid generation is still a difficulty for designing free‐form grid structures. The computational morphogenesis of free‐form grid structures with the Voronoi diagram is proposed to solve this difficulty. Voronoi diagram is introduced to form the irregular grid of structures. Morphologies of plane and curved surface Voronoi grid structure are formulated to realize parametric modeling of the structural grid. A comprehensive structural index is proposed for evaluating free‐form grid structures quantitatively from the aspects of both architectural and structural behaviors. Taking the seeds as optimization variables and the comprehensive structural index as optimization objective, the grid generation problem is transformed into an optimization problem. Numerical examples show that the proposed morphogenesis is feasible and effective for the grid generation of free‐form structures. The free‐form grid structures generated by the proposed method have not only appealing geometry but also good mechanical behavior. The consideration of the symmetry can accelerate the grid generation process. Different grid distributions can be realized with different supports.
The impact of temperature at depth on estimates of thermal habitat for short‐finned pilot whales
Authors: Adamczak Stephanie K. , McLellan William A. , Read Andrew J. , Wolfe Christopher L. P. , Thorne Lesley H. 
Published: September 2020

AbstractShort‐finned pilot whales (Globicephala macrorhynchus) experience dramatic changes in temperature during deep dives, but studies of pilot whale habitat use typically rely solely on surface temperature measurements. We quantified vertically integrated thermal habitat for short‐finned pilot whales using a novel metric, degree‐hours, developed using data from digital acoustic recording tags (DTAGs) deployed off Cape Hatteras along with interpolated temperature profiles at depth from the Met Office Hadley Centre EN4 oceanographic data set. We then compared estimates of thermal habitat calculated from surface waters with estimates of vertically integrated thermal habitat calculated using EN4 data collected along the eastern seaboard of the U.S. to understand how available thermal habitat is influenced by seasonal and spatial variability in water temperature. Estimates of vertically integrated thermal habitat were typically lower than estimates produced using surface temperatures, and the difference was greatest at intermediate latitudes and in warmer seasons, where and when there is a high degree of variability between surface and bottom temperatures. Our work highlights the importance of considering temperature at depth to accurately assess the thermal habitat of deep‐diving marine vertebrates, and presents a means of quantifying thermal habitat that will be useful for understanding the thermal ranges of these species.
Short‐ and long‐term effects of fire on stem hydraulics inPinus ponderosasaplings
Authors: Partelli‐Feltrin Raquel , Smith Alistair M.S. , Adams Henry D. , Kolden Crystal A. , Johnson Daniel M. 
Published: September 2020

AbstractUnderstanding tree physiological responses to fire is needed to accurately model post‐fire carbon processes and inform management decisions. Given trees can die immediately or at extended time periods after fire, we combined two experiments to assess the short‐ (one‐day) and long‐term (21‐months) fire effects onPinus ponderosasapling water transport. Native percentage loss of conductivity (nPLC), vulnerability to cavitation and xylem anatomy were assessed in unburned and burned saplings at lethal and non‐lethal fire intensities. Fire did not cause any impact onnPLC and xylem cell wall structure in either experiment. However, surviving saplings evaluated 21‐months post‐fire were more vulnerable to cavitation. Our anatomical analysis in the long‐term experiment showed that new xylem growth adjacent to fire scars had irregular‐shaped tracheids and many parenchyma cells. Given conduit cell wall deformation was not observed in the long‐term experiment, we suggest that the irregularity of newly grown xylem cells nearby fire wounds may be responsible for decreasing resistance to embolism in burned plants. Our findings suggest that hydraulic failure is not the main short‐term physiological driver of mortality forPinus ponderosasaplings. However, the decrease in embolism resistance in fire‐wounded saplings could contribute to sapling mortality in the years following fire.
Action spectrum of the redox state of the plastoquinone pool defines its function in plant acclimation
Authors: Mattila Heta , Khorobrykh Sergey , Hakala‐Yatkin Marja , Havurinne Vesa , Kuusisto Iiris , Antal Taras , Tyystjärvi Taina , Tyystjärvi Esa 
Published: September 2020

SUMMARYThe plastoquinone (PQ) pool mediates electron flow and regulates photoacclimation in plants. Here we report the action spectrum of the redox state of the PQ pool in Arabidopsis thaliana, showing that 470–500, 560 or 650–660 nm light favors Photosystem II (PSII) and reduces the PQ pool, whereas 420–440, 520 or 690 nm light favors Photosystem I (PSI) and oxidizes PQ. These data were used to construct a model predicting the redox state of PQ from the spectrum of any polychromatic light source. Moderate reduction of the PQ pool induced transition to light state 2, whereas state 1 required highly oxidized PQ. In low‐intensity PSI light, PQ was more oxidized than in darkness and became gradually reduced with light intensity, while weak PSII light strongly reduced PQ. Natural sunlight was found to favor PSI, which enables plants to use the redox state of the PQ pool as a measure of light intensity.
Coping Amongst Elite-Level Sports Coaches: A Systematic Review
Authors: Olsen Maja Gunhild , Haugan Jan Arvid , Hrozanova Maria , Moen Frode 
Published: September 2020

The current study presents a systematic review of six empirical research studies that have explored coping amongst elite-level sport coaches. The study was carried out employing Fletcher et al.’s meta-model of stress, emotions, and performance as a basis for the review. The present results clearly revealed that, despite being an important aspect of coaches’ functioning, coping is almost never researched in its full complexity, and scarce attention is given to cognitive appraisals and long-term outcomes. To our knowledge, current research has so far been limited to the perceived stressors and employed coping strategies. Compared with problem-focused coping, emotion-focused coping is less frequently reported. Emotion-focused coping also has some limitations regarding occurrence and diversity in reported strategies. The reasons for this are not well-known due to the lack of comprehensiveness in the research. Hence, researchers are encouraged to further investigate coping amongst elite-level coaches and to do so by treating it as a concept affected by appraisals and personal and situational characteristics that exist in the context of a larger stress process.
Asian paleomonsoon variation linked to “tripolar” environmental changes
Authors: Zhisheng* An , Weijian Zhou , Zeke* Zhang , Youbin Sun , Yanjun Cai , Li Li , Zhengguo Shi , Hong Chang , Hong Yan 
Published: September 2020

ABSTRACTGlobal warming and ice melting in the “tripolar” regions, namely, Antarctica, the Arctic, and the Tibetan Plateau, might lead to a reorganization of the global climate system. Understanding the dynamic links between the “tripolar” environments and the Earth climate system is crucial to improving our capability to project future climate variability. “Tripolar” changes have influenced the onset and evolution of the Asian paleomonsoon system through various atmospheric and/or oceanic mechanisms. Here, we summarize previously reported Asian paleomonsoon variations that can be linked to “tripolar” environmental changes, from tectonic to millennial time scales, and explore linkages between the “tripolar” regions and global climate changes.
Ocular surface biopsies of patients with xeroderma pigmentosum in the United Kingdom: a retrospective observational case series
Authors: Vekinis John , Morley Ana M Susana 
Published: September 2020

Background/AimsTo describe the results of all ocular surface biopsies performed on patients with xeroderma pigmentosum (XP) under the care of the UK Nationally Commissioned XP Service as well as the treatment of any subsequent ocular surface conditions diagnosed.MethodsRetrospective analysis of medical records. All patients with XP seen by the service from 2010 to 2019 were included and those with ocular surface biopsies were identified. Data was collected on demographics, complementation subgroup (A–G and V), biopsy details, histopathological analysis and subsequent management.ResultsOf 108 patients seen in our service, 17 underwent at least one ocular surface biopsy. 45 biopsy samples were available from 13 patients of which 65% were performed on patients from complementation subgroup C (XP-C). Biopsies were categorised as either non-mapping (clinically abnormal ocular surface tissue) or mapping (multiple sites including clinically normal tissue). 67 percent of non-mapping biopsies had a mass as their indication and 46% showed ocular surface squamous neoplasia. General non-dysplastic damage was seen in 67% of non-mapping biopsies and melanocytic changes were seen in 25% of non-mapping and 81% of mapping biopsies. 47 percent of biopsy outcomes required no additional treatment but, of those that did, 50% received mitomycin C.ConclusionsThis is the largest reported series of ocular surface biopsies in patients with XP. It identifies a background of ocular surface melanocytic, degenerative and inflammatory changes, with patients with XP-C showing the most severe effects. We highlight challenges faced in interpreting their histopathology and in planning subsequent treatments.
UK National Artificial Eye Questionnaire study: comparisons between cosmetic shell and artificial eye users. Part 1: demographics, comfort and satisfaction
Authors: Shapira Yinon , Worrell Emma , Ullrich Katja , Litwin Andre , Malhotra Raman 
Published: September 2020

AimsTo compare the unique experiences related to artificial eye (AE) versus cosmetic shell (CS) wear.MethodsIn this observational, cross-sectional study, the National Artificial Eye Questionnaire (NAEQ) was employed nationwide within the National Health Service England. The proportions or mean values of the aetiology of sight or eye loss, demographics, length of prosthesis wear, reported adjustment time to the prosthesis, comfort, discharge and satisfaction of appearance were compared between AE and CS respondents.ResultsOverall, 951 respondents wore an AE, while 238 wore a CS. In both, trauma was the leading cause for the prosthesis (47.6% and 44.1%, respectively); however, these groups differed in the proportions of the other aetiologies (p<0.0001). AE respondents were generally older (p=0.002) and had longer overall prosthesis wear (p<0.0001) compared with CS respondents. The overall comfort score was similarly, relatively high in both AE and CS respondents (80.4±0.73 vs 81.41±1.45; p=0.51). The discharge-related patient satisfaction ranking was relatively low, in both groups, with a small trend towards worse discharge scores among AE wearers (59.41±0.76 vs 62.26±1.52, p=0.094). Self-reported length of time that has taken to adjust to wearing the prosthesis was not significantly different (p=0.17). Appearance of the eye (p=0.032) and motility of the prosthesis (p<0.0001) were ranked superior by CS respondents compared with AE.ConclusionsThis study characterises unique aspects of CS versus AE in a large national cohort. The results should provide reinforcement to the gain in popularity of CS.
Characteristics and outcomes of admitted patients infected with SARS-CoV-2 in Uganda
Authors: Kirenga Bruce , Muttamba Winters , Kayongo Alex , Nsereko Christopher , Siddharthan Trishul , Lusiba John , Mugenyi Levicatus , Byanyima Rosemary K , Worodria William , Nakwagala Fred , Nantanda Rebecca , Kimuli Ivan , Katagira Winceslaus , Bagaya Bernard Sentalo , Nasinghe Emmanuel , Aanyu-Tukamuhebwa Hellen , Amuge Beatrice , Sekibira Rogers , Buregyeya Esther , Kiwanuka Noah , Muwanga Moses , Kalungi Samuel , Joloba Moses Lutaakome , Kateete David Patrick , Byarugaba Baterana , Kamya Moses R , Mwebesa Henry , Bazeyo William 
Published: September 2020

RationaleDetailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited.ObjectiveWe determined the clinical characteristics and treatment outcomes of patients diagnosed with COVID-19 in Uganda.MeasurementsAs of the 16 May 2020, a total of 203 cases had been confirmed. We report on the first 56 patients; 29 received hydroxychloroquine (HCQ) and 27 did not. Endpoints included admission to intensive care, mechanical ventilation or death during hospitalisation.Main resultsThe median age was 34.2 years; 67.9% were male; and 14.6% were <18 years. Up 57.1% of the patients were asymptomatic. The most common symptoms were fever (21.4%), cough (19.6%), rhinorrhea (16.1%), headache (12.5%), muscle ache (7.1%) and fatigue (7.1%). Rates of comorbidities were 10.7% (pre-existing hypertension), 10.7% (diabetes) and 7.1% (HIV), Body Mass Index (BMI) of ≥30 36.6%. 37.0% had a blood pressure (BP) of >130/90 mm Hg, and 27.8% had BP of >140/90 mm Hg. Laboratory derangements were leucopenia (10.6%), lymphopenia (11.1%) and thrombocytopenia (26.3%). Abnormal chest X-ray was observed in 14.3%. No patients reached the primary endpoint. Time to clinical recovery was shorter among patients who received HCQ, but this difference did not reach statistical significance.ConclusionMost of the patients with COVID-19 presented with mild disease and exhibited a clinical trajectory not similar to other countries. Outcomes did not differ by HCQ treatment status in line with other concluded studies on the benefit of using HCQ in the treatment of COVID-19.
‘It is a different type of learning’. A survey-based study on how simulation educators see and construct observer roles
Authors: O’Regan Stephanie , Molloy Elizabeth , Watterson Leonie , Nestel Debra 
Published: September 2020

BackgroundSimulation is reported as an appropriate replacement for a significant number of clinical hours in pregraduate programmes. To increase access for learners, educators have looked to understanding and improving learning in observer roles. Studies report equivalent learning outcomes and less stress in observer roles. However, reports on the prevalence, use and perceived value of observer roles from the educator’s perspective are lacking.MethodsAn exploratory survey for Australian and New Zealand (ANZ) simulation educators based on literature findings was developed and piloted with a small sample (n=10) of like subjects for language, clarity, skip logic and completion time. The final survey comprised 36 questions. Quantitative data were analysed using Pearson’s chi-squared test, Welch’s ANOVA and exploratory factor analysis. Select qualitative data were analysed using content analysis and summarised with frequency counts and categorisation.ResultsTwo hundred and sixty-seven surveys were completed, with 221 meeting criteria for analysis. The observer role is widely used in ANZ and most learners experience both hands-on and observer roles. The location of observers is dependent upon several factors including facility design, learner immersion, scenario design and observer involvement. Verbal briefings and/or other guides are provided to 89% of observers to direct their focus and 98% participate in the debrief. Educators value observer roles but tend to believe the best learning is hands-on.ConclusionsThe learning in observer roles is less valued by educators than hands-on roles. Focused observation provides opportunities for noticing and attributing meaning, an essential skill for clinical practice. Learning spaces require consideration of scenario design and learning objectives. Scenario design should include objectives for observer roles and incorporate the observer into all phases of simulation. Attention to these areas will help promote the value of the different type of learning available in observer roles.
Handheld electronic device use in patient care: the emergency department patient perspective—a cross-sectional survey
Authors: Tilbury Nicholas , Johnson Graham D , Rusk Zoe , Byrne Carol , Shergill Maleasha , Churchman Adam , Tabner Andrew 
Published: September 2020

BackgroundStaff use of smartphones and tablets in the healthcare setting is increasingly prevalent, but little is known about whether this use is acceptable to patients. Staff are concerned that the use of handheld electronic devices (HEDs) may be negatively misconstrued by patients. The HED can be a valuable tool, offering the emergency clinician access to a wealth of resources; it is therefore vital that patient views are addressed during their widespread adoption into clinical practice.MethodsPatients, or those accompanying them, within the ED of the Royal Derby Hospital between April and June 2017 were asked to complete a survey consisting of 22 questions. Data collection took place to include all times of day and every day of the week. Every eligible individual within the department during a data collection period was approached.ResultsA total of 438 respondents successfully completed the survey with a response rate of 92%. Only 2% of those who observed staff using HEDs during their ED visit thought that they were being used for non-clinical purposes. 339 (78%) agreed that staff should be allowed to use HEDs in the workplace. Concerns expressed by respondents included devices being used for non-clinical purposes and data security. The main suggestion by respondents was that the purpose of the HEDs should be explained to patients to avoid misinterpretation.ConclusionOur survey shows that the majority of survey respondents felt that clinical staff should be allowed to use HEDs in the workplace and that many of the concerns raised could be addressed with adequate patient information and clear governance.
RASA1 phenotype overlaps with hereditary haemorrhagic telangiectasia: two case reports
Authors: El Hajjam Mostafa , Mekki Ahmed , Palmyre Aurelien , Eyries Melanie , Soubrier Florent , Bourgault Villada Isabelle , Ozanne Augustin , Carlier Robert Yves , Chinet Thierry 
Published: September 2020

Background We report two cases of RASA1-related capillary malformation-arteriovenous malformation (CM-AVM1) syndrome mimicking hereditary haemorrhagic telangiectasia (HHT).Methods and results A 28-year-old man, previously embolised for cerebral arteriovenous malformations (AVMs), presented with epistaxis and typical nasal telangiectasias of HHT. CT scan revealed a large portocaval shunt. The second patient was a 9-year-old girl presenting with cyanosis and several mucocutaneous telangiectasias, similar to those observed in typical cases of HHT. CT scan revealed a huge and complex pulmonary AVM of the right lower lobe and a hepatic AVM within the left lobe. HHT diagnosis was considered possible according to the Curaçao criteria for the two patients, with at least two criteria for each. Genetic tests did not find any mutation in the three classic genes (Endoglin, Activin receptor-like kinase 1 or Mothers against decapentaplegic homolog 4), but identified in both cases an RASA1 mutation, known to cause CM-AVM1 syndrome.Conclusions Pulmonary AVM and portocaval shunt, usually encountered in HHT, have not yet been described in the CM-AVM1 syndrome. RASA1 screening may be considered in case of HHT suspicion, particularly when mutations are not found in the usually affected genes.
Minimally invasive surgiscopic evacuation of intracerebral hemorrhage
Authors: Troiani Zachary , Ascanio Luis C , Yaeger Kurt A , Ali Muhammad , Kellner Christopher Paul 
Published: September 2020

Intracerebral hemorrhage (ICH) is a devastating form of stroke associated with a 40% mortality rate at 30 days and a 75% functional dependence rate at 6 months. The role of surgery to treat ICH remains controversial. Preclinical studies suggest minimally invasive clot evacuation following ICH may benefit patients by mitigating primary and secondary brain injury.1 2 In this video, we report the operative technique used in minimally invasive surgicsopic evacuation following ICH (video 1). We demonstrate our presurgical approach using preoperative volumetric imaging loaded onto a stereotactic guidance system. Evacuation of intraparenchymal and intraventricular components of a hemorrhage are shown under direct surgiscopic vision using the Aurora System (Integra LifeSciences, Princeton, NJ, USA). Hemostasis is achieved when actively bleeding vessels are directly cauterized and irrigation of the clot cavity yields no fresh blood. Pre- and postevacuation radiographic differences illustrate the mitigation of clot burden in an elderly patient.Video 1
Indian medical graduates in New Zealand: does anyone win?
Authors: Kumar Rishi 
Published: September 2020

ABSTRACTMedical migration has become a global phenomenon, partly led by easier air travel, economic factors and the expansion of medical technology. New Zealand has gradually evolved from being ‘bicultural’ to a multicultural, multitextured society. The movement of the Indian people, particularly Indian physicians, will be the focus of this paper. In the last three decades, migration eligibility in New Zealand has changed from countries of origin or ability to speak English, to profession and skills. Despite struggling with its own issues, New Zealand has proven to be a preferred destination for Indian medical graduates (IMGs). India is widely recognised as the largest ‘donor country’ for doctors, many of whom go on to establish themselves as leaders and prominent figures in their field. This migration involves three parties: India as a donor country, New Zealand as a recipient country and IMGs as the drivers of this process. Factors behind this growing phenomenon are examined and recommendations are made so that all three parties can benefit from it.
Does thermal plasticity affect susceptibility to capture in fish? Insights from a simulated trap and trawl fishery
Authors: Hollins J. , Koeck B. , Crespel A. , Bailey D.M. , Killen S.S. 
Published: September 2020

In fishes, physiological and behavioural traits can correlate with vulnerability to capture with fishing gears, highlighting the capacity of fisheries selection to drive phenotypic change in exploited populations. There remains a paucity of information regarding how different fishing gears may select on phenotypic traits and how relationships between individual traits and capture vulnerability change across environmental gradients. By simulating the capture process in a trawl and trap using wild minnows (Phoxinus phoxinus) acclimated to different temperatures, we investigated how contrasting fishing gears select on behavioural and physiological traits and how this selection is modulated by temperature. Despite similar risk of capture in each gear, selection differed between traps and trawls. Fish exhibiting low spontaneous activity were at greater capture risk in the trawl across all temperatures, while traps showed no selection except at 24 °C. No relationships between physiological traits and capture vulnerability were found, except between swim performance and trap capture vulnerability at 24 °C. This study demonstrates that fisheries selection on individual traits is likely context-specific, depending on both fishing gear type and environment.