bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Primary Tumor Surgery Prolongs the Medium Cancer Specific Survival in Metastatic Colorectal Cancer Patients with Initial Isolated Unresectable Lung Metastasis: A SEER-based Retrospective Study
Authors: Gao Yu , Xia Ling , Liu Qi , Dai Jing , Zhou Fuxiang , Liang Chen 
Published: December 2020

Abstract
Background: The efficiency of primary tumor surgery (PTS) to patients who are diagnosed as colorectal cancer (CRC) with initial isolated unresectable lung metastasis (URLM) is still on debates.Methods: 1580 patients are involved in this study eventually, data from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Chi-square (Χ2) test examines the categorical variables. Hazard ratio (HR) and 95% confidence interval (95% CI) are used as the estimation of risk for mortality in univariate and multivariate Cox regression. Propensity score match (PSM) simulates the random progress. Kaplan-Meier method outputs the medium cancer specific survival (mCSS) and delineates the survival curve.Results: After PSM, PTS prolongs the mCSS time in surgery group compared to no-surgery group (40 months vs. 14 months, HR=0.396, P<0.001), and raises the 3-year CSS rate (37% vs. 12%, P<0.001). Radiotherapy has further survival benefits in surgery group (49 months vs. 32 months, HR=0.434, P=0.001). Chemotherapy, radiotherapy, and no peritoneum metastasis have better mCSS (31 months, 33 months, 30months respectively). Multivariate Cox regression turns out that patients older than 75 (HR=1.869, P<0.001), with poor differentiation or undifferentiation pathological grade (HR=1.796, P<0.001), with peritoneum metastasis (HR=1.650, P<0.001) have higher risks of death, and PTS (HR=0.396, P<0.001), chemotherapy (HR=0.330, P<0.001) are favor prognostic factors in mCRC with URLM.Conclusion: This study affirms the effectiveness of primary tumor surgery in the colorectal cancer patients with initial isolated unresectable lung metastasis. More random clinical trials or real-world researches need to be implemented.
Different Patterns of Pneumothorax in Patients With Soft Tissue Tumors Treated With Pazopanib
Authors: Aiba Hisaki , Kimura Hiroaki , Yamada Satoshi , Okamoto Hideki , Hayashi Katsuhiro , Miwa Shinji , Kawaguchi Yohei , Saito Shiro , Sakai Takao , Tatematsu Tsutomu , Nakanisi Ryoichi , Murakami Hideki 
Published: December 2020

Abstract
Background: To investigate the patterns of pneumothorax in pazopanib treatment, focusing on the positional relationship between the visceral pleura and metastatic lung tumor. Methods: We examined 20 patients with advanced soft tissue tumor who developed lung metastases before pazopanib treatment during 2012–2019. Pneumothorax was classified into two types based on the location of the metastatic lesion around the visceral pleural area before pazopanib treatment: subpleural type, within 5 mm from the pleura; central type, > 5 mm from the pleura. We investigated the rates of pneumothorax and the risk factors. Results: Overall, 5 patients experienced pneumothorax (3 subpleural and 2 central type). Cavitation preceded pneumothorax in 80% of the patients and led to connection of the cavitated cyst of the metastatic lesion to the chest cavity in a shorter term in those with the subpleural type. Conversely, a more gradual increase in cavity and sudden cyst rupture were observed in the central type. The risk factors for pneumothorax were cavitation after the initiation of pazopanib and previous intervention before pazopanib including ablation or surgery. The locations of metastatic lesion were not risk factor for the occurrence of pneumothorax.Conclusion: Pneumothorax is an adverse event of pazopanib treatment. Therefore, attention must be paid to the predisposing factors such as the formation of cavitation after pazopanib initiation and previous interventions on the lungs. Moreover, as the subpleural pneumothorax tends to occur earlier than the central type, the different time course can be anticipated based on the positional relationships of the metastatic lesions to the visceral pleura.
Prognostic Factors in Patients with Advanced HER2-Positive Gastric Cancer Treated with Trastuzumab-Based Chemotherapy: A Cohort study
Authors: Marshall Shoko , Wakatsuki Takeru , Takahari Daisuke , Matsushima Tomohiro , Ishizuka Naoki , Nakayama Izuma , Osumi Hiroki , Ogura Mariko , Ichimura Takashi , Shinozaki Eiji , Chin Keisho , Yamaguchi Kensei 
Published: December 2020

Abstract
Background: Prognostic factors for the survival of patients with advanced HER2-positive gastric cancer treated with trastuzumab-based chemotherapy remain controversial. The aim of this study was to reveal the clinical factors that predict prognosis in this patient population.Methods: We retrospectively reviewed the medical records of HER2-positive gastric cancer patients treated with trastuzumab-based chemotherapy in our institution. Clinical features and laboratory test results considered prognostic factors were re-examined. Overall survival (OS) was estimated using the Kaplan-Meier method, univariate analysis was performed with the log-rank test, and multivariate analysis using Cox’s proportional hazard regression model.Results: A total of 133 patients with advanced HER2-positive gastric cancer were enrolled. The median OS in this cohort was 18.7 months. Four prognostic factors: visceral metastasis (lung or liver), and levels of haemoglobin (Hb) (< 11.6 g/dL), lactate dehydrogenase (LDH) (> 222 mg/dL), and C-reactive protein (CRP) (> 0.14 mg/dl) were identified as independent prognostic factors. After classifying the patients in three groups according to their number of prognostic factors, namely low (0,1), moderate (2,3), and high (4) risk, OS curves were separated into three categories with median OS of 32.0, 18.7, and 10.1 months, respectively (p=0.00025). Compared to the low-risk group, hazard ratios for the moderate- and high-risk groups were 1.75 (95% CI: 1.05–2.93) and 3.49 (95% CI: 1.81–6.71), respectively.Conclusion: Visceral metastasis and abnormal Hb, LDH, and CRP test results were associated with unfavourable OS. These findings are helpful for the management of advanced HER2-positive gastric cancer treated with trastuzumab-based chemotherapy.
One Year of Procarbazine Lomustine and Vincristine is Poorly Tolerated in Low Grade Glioma: A Real World Experience in a National Neuro-Oncology Centre
Authors: Keogh Rachel , Aslam Razia , Hennessy Maeve , Coyne Zac , Hennessy Bryan , Breathnach Oscar , Grogan Liam , Morris Patrick 
Published: December 2020

Abstract
BackgroundFollowing optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG). However, one year of PCV is associated with significant toxicities. In the pivotal RTOG 9802 randomised control trial, approximately half of the patients discontinued treatment after six months. As patients on clinical trials may be fitter, we aimed to further explore the tolerability of PCV chemotherapy in routine clinical practice. MethodsWe conducted a retrospective study between 2014 and 2018 at a National Neuro-Oncology centre. Patients who had received PCV during this time period were included. The primary objective was to assess tolerability of treatment. Secondary objectives included evaluation of treatment delays, dose modifications and toxicities. ResultsOverall, 41 patients were included, 24 (58%) were male and 21 (51%) aged ≥ 40 years. Overall, 38 (93%) underwent surgical resection and all patients received adjuvant radiotherapy prior to chemotherapy. The median number of cycles completed was 3,2,4 for procarbazine, lomustine and vincristine respectively. Only 4 (10%) completed all six cycles of PCV without dose modifications. There was a universal decline in dose intensity as cycles of chemotherapy progressed. Dose intensity for cycle 1 versus cycle 6 respectively: procarbazine (98% versus 46%), lomustine (94% versus 48%) and vincristine (93% versus 50%). Haematological toxicities were common. Six (14%) patients experienced Grade III-IV thrombocytopaenia and 13 (31%) experienced Grade III-IV neutropaenia. Conclusion﻿Toxicities are frequently observed with the PCV regimen in clinical practice. It might be preferable to adjust doses from the start of chemotherapy to improve tolerability or consider alternative chemotherapy, particularly in older patients with LGG.
Research Priorities and Indicators for Lifestyle Programs to Address Cardiometabolic Conditions
Authors: Brauer Paula , Desroches Sophie , Dhaliwal Rupinder , Li Airu , Wang Yiran , Conklin Annalijn , Klein Doug , Drouin-Chartier Jean-Philippe , Robitaille Julie , Horne Justine , Ponta Monia , Burns Rachel , Harding Scott , Hosseini Zeinab 
Published: December 2020

Abstract
Background: Cardiometabolic conditions are a major and growing health burden in many countries. At least one-third of middle-aged adults with overweight and obesity develop various combinations of type 2 diabetes, hypertension, dyslipidemia, and other cardiometabolic conditions. Currently, all relevant clinical and community guidelines recommend lifestyle (e.g. diet and physical activity) interventions, yet current evidence suggests limited and variable uptake by either primary care or public health services. New implementation research in lifestyle interventions is needed in multiple jurisdictions. As part of this effort, some agreement within the research community on priorities and core measures and indicators across studies would improve comparability and drive progress. Members of a new volunteer network undertook a first Delphi process to determine initial consensus.Methods: Network members were invited by email to participate and completed two rounds of a modified Delphi process delivered through online questionnaire and teleconferences. Results were sent back to participants at the end of each round of the survey. High priority with consensus was defined as the median and 25-75%ile range within the 7 to 9 range on a 9-point scale. Results: Fifty-three people were invited and provided with a link to the first questionnaire. Twenty-five (47%) and 18 (34%) participants completed the round 1 and round 2 surveys, respectively. Of 22 possible research priorities, four were rated high priority with consensus, including: evaluating the efficacy and effectiveness of interventions in place, improving existing interventions for sustainability, and clinical and public health research to advance existing knowledge to develop new capacities. Of the 93 measures and indicators proposed, 15 achieved consensus with an additional nine measures having high medians, but greater variance.Conclusions: This first effort suggests a wide range of research priorities within the group, but also broad agreement on a few core implementation research priorities. There is currently limited agreement on core indicators/measures for implementation studies and additional work is needed. The results provide a starting point for further development of common measures for implementation research in lifestyle interventions for cardiometabolic conditions.
Aircraft Pipe Geometric Feature Modeling and Error Compensation Based on Assembly Constraints
Authors: Lan Yulong , Chen Songlin , Gao Wenxiang , Li Bangyi , Tang Mutian 
Published: December 2020

Abstract
An error compensation method based on the assembly constraints of aircraft pipe is proposed for solving the problem of frequent failures caused by high assembly stress in the actual assembly process. Firstly, the pipe assembly process’ geometric modeling is carried out using geometric modeling method, and a new modeling method based on axis vector is proposed. On this basis, the Rodrigues formula was used to establish a pipe space pose calculation model based on actual assembly conditions. Then, the assembly constraints are analyzed, and the key constraint features are identified based on the pipe assembly requirements. Subsequently, the pipe assembly scenarios under different constraint forms are analyzed, and the pipe error compensation methods under a single constraint and associated constraint are respectively proposed. Finally, a typical flaring pipe is selected for the test; the pipe assembly error compensation calculation and the pipe installation air tightness test are carried out respectively. The results show that the proposed method could effectively realize the theoretical space pose adjustment and the pipe parameter compensation, and the air tightness of the compensated pipe is better than that of the uncompensated one.
A Multi-Scale Bioinformatics Study on Novel Mechanism of Xintong Granule for Treating Coronary Heart Disease by Network Pharmacology and Molecular Docking Verification
Authors: Huang Zhihong , Guo Siyu , Fu Changgeng , Zhou Wei , Zhang Jingyuan , Liu Xinkui , Jia Shanshan , Wu Chao , Lu Shan , Li Bingbing , Wu Zhishan , Tan Yingying , Fan Xiaotian , Cheng Guoliang , Wu Jiarui 
Published: December 2020

Abstract
Background: Xintong Granule (XTG) is a Chinese patent medicine composed of 13 Chinese herbs, which is widely used in the treatment of coronary heart disease (CHD). However, there are few studies on it, and its potential pharmacological mechanism needs to be further elucidated.Methods: In this study, network pharmacology was employed to construct the drug-compounds-targets-pathways molecular regulatory network of the treatment of CHD to explore the effective compounds of XTG and its underlying pharmacological mechanism. First, we established the related ingredients and potential targets of these ingredients databases by Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and A Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM). Next, the CHD targets were obtained in DigSee, OMIM, DisGeNET, TTD, GeneCards and GenCLiP3 database. Then, protein-protein interaction (PPI) analysis, GO and KEGG pathway enrichment analysis were carried out and the core targets were filtered by topology. Moreover, molecular docking was performed to assess the binding potential of hub targets and key compounds.Results: The result reflected that 178 components of XTG and 669 putative therapeutic targets were screened out. After a systematic and comprehensive analysis, we identified 9 hub targets (TNF, MAPK1, STAT3, IL6, AKT1, INS, EGFR, EGF, TP53) primarily participated in the comprehensive therapeutic effect related to blood circulation, vascular regulation, cell membrane region, compound binding, receptor activity, signal transduction, AGE-RAGE signaling pathway in diabetic complications, JAK-STAT signaling pathway, PI3K-AKT signaling pathway and MAPK signaling pathway.Conclusion: The results of this study tentatively clarified the potential targets and signaling pathways of XTG against CHD, which may benefit to the development of clinical experimental research and application.
Dynamic 68Ga-DOTATATE PET/MRI&nbsp;in the Diagnosis and Management of Intracranial Meningiomas
Authors: Ivanidze Jana , Roytman Michelle , Skafida Myrto , Kim Sean , Glynn Shannon , Osborne Joseph R. , Pannullo Susan C. , Lin Eaton , Karakatsanis Nicolas A 
Published: December 2020

Abstract
Background: While MRI is the gold standard for meningioma diagnosis and treatment planning, it poses limitations in differentiating residual/recurrent disease from post-treatment-change. 68Ga-DOTATATE PET/MR of 50 min with standardized uptake value (SUV) analysis has demonstrated clinical utility in patients with meningioma. However, SUV is considered semi-quantitative with limited reproducibility depending on several variable parameters not accounted for in its definition. Dynamic PET acquisitions enable parametric imaging accounting for post-injection time to improve quantification. Our purpose was to assess feasibility and clinical utility of dynamic 68Ga-DOTATATE PET/MR with multi-parametric SUV and Patlak analysis in the diagnosis and management of intracranial meningioma. Results: 19 subjects with meningioma underwent dynamic 68Ga-DOTATATE PET/MR. Time-activity curves were generated in 84 volumes of interest (53 meningioma, 9 post-treatment-change, 22 cranial blood pool reference in superior sagittal sinus, SSS). Region-specific net binding rate constant Ki was determined using the standard and generalized Patlak (sPatlak and gPatlak) methods with a population-based reference input function. Absolute and relative mean and maximum SUVs were extracted from the 50 minutes (SUV50) and the last 10 minutes (SUV10) of acquisition. Spearman correlation, Mann-Whitney, and Wilcoxon tests were performed. In meningioma, absolute and relative maximum SUV50 demonstrated a strong, significant, positive correlation with sPatlak Ki (r = 0.82, p < 0.0001 and r = 0.85, p < 0.0001, respectively). Similar results were found in post-treatment-change regions (r = 0.88, p = 0.007 and r = 0.83, p = 0.015, respectively). Mean SUV50 demonstrated similar correlations with sPatlak Ki in both subgroups. No significant differences were observed between sPatlak and gPatlak Ki correlations with SUV. All SUV and Ki metrics were significantly higher in meningioma versus post-treatment-change regions. SUV50 and SUV10 metrics for each sub-cohort were not significantly different. No lesions were reclassified based on SUV10 or Ki compared to SUV50. Conclusions: Multi-parametric SUV and Patlak Ki analysis with 68Ga-DOTATATE PET/MR is feasible and can differentiate meningioma from post-treatment-change. Ki may improve quantification of postoperative residual/ recurrent meningioma. SUV10 and SUV50 yielded comparable quantification suggesting feasibility for shorter PET scans.Trial Registration Number (ClinicalTrials.gov ID): NCT04081701, Registration Date: September 9, 2019
National Survey Regarding the Timing of Endoscopic Procedures during the Covid-19 Pandemic
Authors: Marroquín-Reyes José Daniel , Zepeda-Gómez Sergio , Tepox-Padrón Alejandra , Quintanar-Martínez Mariana , Trujillo-Benavides Omar Edel , Téllez-Avila Félix I. 
Published: December 2020

Abstract
Background: During the COVID-19 pandemic, several questions have arisen about which endoscopic procedures (EPs) must be performed and which ones can be postponed. The aim of this study was to conduct a nationwide survey regarding the appropriate timing of EPs during the COVID-19 pandemic. Methods: This prospective study was performed through a nationwide electronic survey. The survey consisted of 15 questions divided into three sections. The first evaluated the agreement for EPs classified as “time sensitive” and “not time sensitive”. Two other sections assessed “high-priority” and “low-priority” scenarios. Agreement was considered when >75% of respondents answered a question in the same direction. Results: The response rate was 27.2% (214/784). Among the respondents, agreement for the need to perform EP in <72 hours was only reached for variceal bleeding (93.4%). Dysphagia with alarm symptoms was the scenario in which the highest percentage of physicians (95.9%) agreed that an EP needed to be performed within a month. Less than 30% of endoscopists would perform an EP within the first 72 hours for patients with mild cholangitis, non-variceal upper gastrointestinal bleeding without hemodynamic instability, or severe anaemia without overt bleeding. In time-sensitive clinical scenarios suggestive of benign disease, none of the scenarios reached agreement in any sense. Among the time-sensitive clinical scenarios suggestive of malignancy, >90% of the surveyed respondents considered that EP could not be postponed for >8 weeks. Conclusions: There was no consensus among endoscopists about the timing of EPs in patients with pathologies considered time sensitive or in those with high-priority pathologies. Agreement was only reached in five (17%) of the evaluated clinical scenarios.
Communication patterns in the doctor–patient relationship: evaluating determinants associated with low paternalism in Mexico.
Authors: Lazcano-Ponce Eduardo , Angeles-Llerenas Angelica , Rodríguez-Valentín Rocío , Salvador-Carulla Luis , Domínguez-Esponda Rosalinda , Astudillo-García Claudia Iveth , de León Eduardo Madrigal , Katz Gregorio 
Published: December 2020

Abstract
Background: Paternalism/overprotection limits communication between healthcare professionals and patients and does not promote shared therapeutic decision-making. In the global north, communication patterns have been regulated to promote autonomy, whereas in the global south, they reflect the physician’s personal choices. The goal of this work was contribute to knowledge of the communication patterns used in clinical practice in Mexico and to identify the determinants that favour a doctor-patient relationship characterized by low paternalism/autonomy.Methods: A self-report study of communication patterns within a sample of 761 mental healthcare professionals in Central and Western Mexico was conducted. Multiple ordinal logistic regression models were performed to analyse paternalism and associated factors. Results: A high prevalence (68.7% [95% CI 60.0-70.5]) of paternalism was observed among mental healthcare professionals in Mexico. The main determinants of low paternalism/autonomy were medical specialty (OR 1.67 [95% CI 1.16-2.40]) and gender, with female physicians more likely to explicitly share diagnoses and therapeutic strategies with patients and their families (OR 1.57 [95% CI 1.11-2.22]). A pattern of highly explicit communication was strongly associated with low paternalism/autonomy (OR 12.13 [95% CI 7.71-19.05]). Finally, a modifying effect of age strata on the association between communication pattern or specialty and low paternalism/autonomy was observed.Conclusions: Among mental healthcare professionals in Mexico, an elevated paternalism prevailed. Gender, specialty, and a pattern of open communication were closely associated with low paternalism/autonomy. Strengthening the competencies of health professionals and promoting explicit communication could contribute to the transition towards more autonomist communication in clinical practice in Mexico. The ethical implications will need to be resolved in the near future.