bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions
Authors: Ortega Miguel A. , Fraile-Martinez Oscar , García-Montero Cielo , Diaz-Pedrero Raul , Lopez-Gonzalez Laura , Monserrat Jorge , Barrena-Blázquez Silvestra , Alvarez-Mon Miguel Angel , Lahera Guillermo , Alvarez-Mon Melchor 
Published: December 2024

AbstractMood disorders include a set of psychiatric manifestations of increasing prevalence in our society, being mainly represented by major depressive disorder (MDD) and bipolar disorder (BD). The etiopathogenesis of mood disorders is extremely complex, with a wide spectrum of biological, psychological, and sociocultural factors being responsible for their appearance and development. In this sense, immune system dysfunction represents a key mechanism in the onset and pathophysiology of mood disorders, worsening mainly the central nervous system (neuroinflammation) and the periphery of the body (systemic inflammation). However, these alterations cannot be understood separately, but as part of a complex picture in which different factors and systems interact with each other. Psychoneuroimmunoendocrinology (PNIE) is the area responsible for studying the relationship between these elements and the impact of mind–body integration, placing the immune system as part of a whole. Thus, the dysfunction of the immune system is capable of influencing and activating different mechanisms that promote disruption of the psyche, damage to the nervous system, alterations to the endocrine and metabolic systems, and disruption of the microbiota and intestinal ecosystem, as well as of other organs and, in turn, all these mechanisms are responsible for inducing and enhancing the immune dysfunction. Similarly, the clinical approach to these patients is usually multidisciplinary, and the therapeutic arsenal includes different pharmacological (for example, antidepressants, antipsychotics, and lithium) and non-pharmacological (i.e., psychotherapy, lifestyle, and electroconvulsive therapy) treatments. These interventions also modulate the immune system and other elements of the PNIE in these patients, which may be interesting to understand the therapeutic success or failure of these approaches. In this sense, this review aims to delve into the relationship between immune dysfunction and mood disorders and their integration in the complex context of PNIE. Likewise, an attempt will be made to explore the effects on the immune system of different strategies available in the clinical approach to these patients, in order to identify the mechanisms described and their possible uses as biomarkers.
Land use land cover (LULC) analysis in Nigeria: a systematic review of data, methods, and platforms with future prospects
Authors: Alegbeleye Okikiola Michael , Rotimi Yetunde Oladepe , Shomide Patricia , Oyediran Abiodun , Ogundipe Oluwadamilola , Akintunde-Alo Abiodun 
Published: December 2024

AbstractUnderstanding land use and land cover (LULC) classification is critical for addressing environmental and human needs, particularly in developing countries. Nigeria is a developing country experiencing rapid population growth and economic development leading to increased LULC changes. While many studies have been done on LULC changes, there is a need for a comprehensive review of existing knowledge and limitations of LULC analyses in Nigeria. Hence, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method, this review paper presents a systematic review of LULC analyses in Nigeria by examining the adopted remote sensing data, pre-classified global and regional LULC maps, and classification and validation methods. This paper draws attention to the significant growth in LULC studies and highlights a need for awareness and access to existing and readily available LULC data. This review provides a broad overview of LULC data, classification methods, focus, scale, and constraints associated with LULC analysis in Nigeria. Also, it provides probable solutions to the challenges and GEE-based LULC classification scripts. There is a need to create and prioritize a national LULC data repository to ensure sustainable land monitoring and management in Nigeria. This will facilitate the spatial and temporal assessment of LULC at different scales and regions. High-resolution imagery and advanced classification methods such as deep learning need to be adopted to ensure accurate land cover analysis at different scales. Also, increased awareness programs, collaboration, and capacity-building initiatives will be beneficial to addressing current and emerging challenges related to LULC studies in Nigeria.
Enabling per-file data recovery from ransomware attacks via file system forensics and flash translation layer data extraction
Authors: Dafoe Josh , Chen Niusen , Chen Bo , Wang Zhenlin 
Published: December 2024

AbstractRansomware attacks are increasingly prevalent in recent years. Crypto-ransomware corrupts files on an infected device and demands a ransom to recover them. In computing devices using flash memory storage (e.g., SSD, MicroSD, etc.), existing designs recover the compromised data by extracting the entire raw flash memory image, restoring the entire external storage to a good prior state. This is feasible through taking advantage of the out-of-place updates feature implemented in the flash translation layer (FTL). However, due to the lack of “file” semantics in the FTL, such a solution does not allow a fine-grained data recovery in terms of files. Considering the file-centric nature of ransomware attacks, recovering the entire disk is mostly unnecessary. In particular, the user may just wish a speedy recovery of certain critical files after a ransomware attack. In this work, we have designed $$\textsf{FFRecovery}$$
FFRecovery
, a new ransomware defense strategy that can support fine-grained per file data recovery after the ransomware attack. Our key idea is that, to restore a file corrupted by the ransomware, we (1) restore its file system metadata via file system forensics, and (2) extract its file data via raw data extraction from the FTL, and (3) assemble the corresponding file system metadata and the file data. Another essential aspect of $$\textsf{FFRecovery}$$
FFRecovery
is that we add a garbage collection delay and freeze mechanism into the FTL so that no raw data will be lost prior to the recovery and, additionally, the raw data needed for the recovery can be always located. A prototype of $$\textsf{FFRecovery}$$
FFRecovery
has been developed and our experiments using real-world ransomware samples demonstrate the effectiveness of $$\textsf{FFRecovery}$$
FFRecovery
. We also demonstrate that $$\textsf{FFRecovery}$$
FFRecovery
has negligible storage cost and performance impact.
Mesenteric Visceral Lipectomy Improves Glucose Tolerance in Patients With Type 2 Diabetes: A Pilot Study
Authors: Baskoy Gozde , Peterson Richard M , Kempenich Jason , Triplitt Curtis , Brown Marissa , Clarke Geoffrey D , Cersosimo Eugenio , Andrew Mark S , Lavrynenko Olga , Chavez-Velazquez Alberto O , Hansis-Diarte Andrea , Salehi Marzieh , DeFronzo Ralph A 
Published: December 2024

Abstract

Context
Increased mesenteric visceral fat is associated with the metabolic syndrome, insulin resistance, and type 2 diabetes.

Methods
Using targeted cell separation and extraction technology (TC-SET), we examined the effect of removal of intra-abdominal fat, specifically small bowel mesenteric fat, on glycemic control and insulin sensitivity in 7 individuals with obesity and poorly controlled type 2 diabetes (T2D) (glycated hemoglobin [HbA1c] = 8.9% ± 0.2%; fasting plasma glucose [FPG] = 211 ± 12 mg/dL).

Results
At month 6, both HbA1c and FPG significantly declined to 7.7% (P = .01) and 140 mg/dL (P &lt; .01). At month 12, both the FPG (172 mg/dL, P = .02) and HbA1c (8.1%, P = .10) tended to increase. Time in range (continuous glucose monitoring) increased from 22% to 74% (month 6, P &lt; .001) and 50% (month 12, P &lt; .05). Suppression of endogenous (hepatic) glucose production increased from 29% to 45% (P &lt; .05) and to 43% (P &lt; .01) at months 6 and 12, respectively; whole-body (muscle) insulin-mediated glucose disposal did not change significantly at months 6 and 12. Body weight (106.8 to 103.3 kg) and percent body fat (33.3 to 31.6%) both decreased slightly (P &lt; .05) at month 12. Hepatic fat content (hydrogen-1 magnetic resonance spectroscopy) decreased significantly (23.9 ± 3.7 to 19.1 ± 3.4%, P &lt; .005) at month 12. Insulin secretion and disposition index during oral glucose tolerance testing increased more than 2-fold at month 6 (both P &lt; .05), and these improvements persisted at 12 months.

Conclusion
Mesenteric visceral lipectomy (MVL) shows potential as a novel, minimally invasive approach to improve glycemic control in patients with suboptimally controlled T2D, but further controlled studies are needed to confirm these findings and better understand the potential benefits of MVL.
Potential Utility of Circulating MicroRNA-483 as a Biomarker for IGF-II–Associated Non–Islet Cell Tumor Hypoglycemia
Authors: Okazaki-Hada Mikiko , Nagao Mototsugu , Asai Akira , Okada-Iwabu Miki , Hizuka Naomi , Eliasson Lena , Sugihara Hitoshi , Fukuda Izumi , Iwabu Masato 
Published: December 2024

Abstract

Context
In most cases of non–islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2, has been suggested to be coexpressed with IGF-II.

Objective
The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a biomarker for diagnosis and therapeutic outcome of NICTH.

Methods
Sera from 145 cases of suspected NICTH, and postoperative sera from 25 surgical cases of confirmed NICTH were subjected to Western blot analysis and enzyme-linked immunosorbent assay for IGF-II and quantitative polymerase chain reaction analysis for miR-483-5p and -3p. Tissue miR-483 expression levels were compared between resected solitary fibrous tumors (SFTs) and their surrounding margins from 11 surgical cases.

Results
NICTH was confirmed in 100 out of 145 cases based on the detection of big IGF-II in their sera. Receiver operating characteristic curve analysis revealed that serum miR-483-5p had a better diagnostic ability for NICTH than serum IGF-II or the classical diagnostic marker the IGF-II to IGF-I ratio. Notably, serum miR-483-5p levels decreased significantly with the disappearance of big IGF-II after surgical tumor resection. Tissue miRNA-483-5p and -3p expression levels were significantly higher in resected SFT tissues than in their surgical margins.

Conclusion
Circulating miR-483-5p, derived from IGF-II-producing tumors, appears to be a more reliable biomarker for diagnosis and therapeutic outcome of NICTH than IGF-II or the IGF-II to IGF-I ratio. These findings highlight the clinical utility of miR-483-5p in the management of NICTH.
Multiple Endocrine Neoplasia Type 1 With Adrenal Cortical Adrenocortical Carcinoma: A 25-Year Follow-Up and Family Report
Authors: Yang Mei , Li Sha , Zhong Xiao Wei 
Published: December 2024

Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant genetic disorder characterized by neoplasia of the parathyroid, pancreatic islets, and anterior pituitary. In this report, we present a family case in which the proband was diagnosed with prolactinoma 25 years ago. During the current hospitalization, the patient was diagnosed with insulinoma, primary hyperparathyroidism, and adrenocortical carcinoma. The final diagnosis was MEN1, confirmed by identifying a heterozygous mutation in the MEN1 gene through genetic testing. The proband's son also tested positive for the same MEN1 gene mutation, although he exhibited no clinical symptoms. MEN1 associated with adrenocortical carcinoma is exceptionally rare, carries a high malignancy risk, and has a poor prognosis. Genetic testing for the MEN1 gene is crucial for accurate diagnosis, while family screening is beneficial for early detection, timely treatment, and improving patient outcomes.
Clinical Decision-Making and Process Complications During Anticipated Difficult Airway Management for Elective Surgery
Authors: Yang Isabelle T. , Tung Avery , Flores Kelsey S. , Berenhaut Kenneth S. , Choi Jungbin A. , Bryan Yvon F. 
Published: December 2024

BACKGROUND:
Difficult airway management (DAM) is a challenging aspect of anesthetic care. Although nearly all DAM episodes result in successful intubation, complications are common and clinical decision-making may be complex. In adults with anticipated DAM scheduled for nonemergent surgery, we prospectively observed clinical decisions made during DAM such as awake/sedated versus anesthetized, choice of initial and subsequent devices, case cancellation/postponement, conversions between awake and anesthetized approaches, and process complications such as multiple intubation/supraglottic airway (SGA) insertion attempts, difficult bag-mask ventilation (BMV), hypoxemia, and cardiovascular destabilization.

METHODS:
From 2009 to 2014, we prospectively observed 1295 episodes of anticipated DAM in a convenience sample of 1245 adults scheduled for nonemergent surgery. Trained observers recorded airway management decisions and process complications during DAM. We described clinical decisions made during DAM and outcomes including number of attempts, need for BMV, hypoxemia, and cardiovascular destabilization.

RESULTS:
No cases were canceled/postponed for airway management failure and all intubations were eventually successful. Of the 1295 episodes of airway management in our study cohort, 166 (13%) were intubated awake. Patients intubated awake had more difficult airway indicators than those intubated anesthetized, their first-pass success rate was 49%, 30% required ≥3 attempts, 4% required a device change, 50% experienced hypoxemia, and 29% experienced cardiovascular destabilization. Among the 1129 patients intubated while anesthetized, first-pass success rate was 64% and 20% required ≥3 attempts, 11% required a device change, hypoxemia occurred in 30%, and cardiovascular destabilization in 20%. One patient (0.08%) was converted from an anesthetized to an awake approach. Patients with a failed anesthetized intubation attempt and difficult BMV between attempts were at high risk for multiple attempts (67%) and hypoxemia (100%).

CONCLUSIONS:
Airway management was successful in all patients and the incidence of process complications was higher than in routine airway management. Despite a high risk of DAM, 87% of patients were intubated anesthetized and conversions between awake and anesthetized approaches were rare. That patients intubated awake had more difficult airway indicators implies that clinicians reserve awake intubation for particularly difficult airways. The high incidence of multiple attempts, hypoxemia, and cardiovascular destabilization in patients intubated awake suggests that awake airway management remains challenging. We found no clear pattern in device choices after a first failed attempt. Patients with a first failed anesthetized intubation attempt and difficult BMV were at particularly high risk for hypoxemia.
The Association of Fructose Metabolism With Anesthesia/Surgery-Induced Lactate Production
Authors: Zhang Lei , Liu Jianhui , Miao Zhengjie , Zhou Ren , Wang Hao , Li Xiang , Liu Jiehui , Zhang Jingya , Yan Jia , Xie Zhongcong , Jiang Hong 
Published: December 2024

BACKGROUND:
In elderly individuals, excessive lactate levels in the brain may be associated with the development of cognitive impairment after surgery, including delayed neurocognitive recovery (dNCR). Since the origin of this increased lactate is unknown, here we assessed associations between metabolic pathways and postoperative dNCR.

METHODS:
This study included 43 patients (≥60 years old) who had surgery under general anesthesia. We also used a mouse model in which 20-month-old mice were exposed to sevoflurane to induce postoperative dNCR, while control mice were exposed to 40% oxygen. Mice in the control group and anesthesia/surgery group were injected with fructose or glucose intracerebroventricularly, or fructose metabolism inhibitor intraperitoneally. Barnes maze test and Y maze were used to measure cognitive function in mice. Metabolomics was used to measure metabolites in the serum of patients and the brains of mice after anesthesia/surgery. Isotope labeling and metabolic flux were used to analyze flow and distribution of specific metabolites in metabolic pathways.

RESULTS:
Among 43 patients, 17 developed dNCR. Metabolomics showed significantly decreased postoperative serum fructose 1-phosphate levels in dNCR compared to nondNCR patients (mean difference [×104] = –0.164 ± 0.070; P = .024). Similar results were found in the brains of mice (mean difference = –1.669 ± 0.555; *P = .014). Isotope labeling and metabolic flux experiments in mice showed fructose but not glucose entered glycolysis, increasing lactate levels in the brain after anesthesia/surgery (P < .05). Administration of intraperitoneal fructose inhibitors to mice effectively inhibited increased lactate levels in the brain (mean difference =96.0 ± 4.36, P = .0237) and cognitive dysfunction after anesthesia/surgery (mean difference =69.0 ± 3.94, P = .0237). In a small subsample, we also found anesthesia/surgery increased interleukin-6 (IL-6) levels in the brains of mice (mean difference =88.3 ± 3.44, P = .0237) and that IL-6 may function upstream in fructose activation.

CONCLUSIONS:
These results suggest that anesthesia/surgery activates fructose metabolism, producing excessive lactate in the brain that is associated with postoperative cognitive impairment. Fructose metabolism is thus a potential therapeutic target for dNCR.
Residual force enhancement is not altered while force depression is amplified at the cellular level in old age
Authors: Njai Binta S. , Hinks Avery , Patterson Makenna A. , Power Geoffrey A. 
Published: December 2024

ABSTRACT
Residual force enhancement (rFE) and residual force depression (rFD) are history-dependent properties of muscle which refer to increased and decreased isometric force following a lengthening or shortening contraction, respectively. The history dependence of force is greater in older than in younger human adults when assessed at the joint level. However, it is unclear whether this amplification of the history dependence of force in old age is owing to cellular mechanisms or is a consequence of age-related remodelling of muscle architecture. Single muscle fibres from the psoas major of old and young F344BN rats were dissected and chemically permeabilized. Single muscle fibres were mounted between a force transducer and length controller, then maximally activated (pCa 4.5). To assess rFD, fibres were actively shortened from 3.1 to 2.5 µm at both a slow (0.15 Lo s−1) and fast (0.6 Lo s−1) speed, with a fixed-end isometric reference contraction at 2.5 µm. To assess rFE, fibres were activated and stretched at 0.3 Lo s−1 from a sarcomere length of 2.2 to 2.5 µm, and 2.7 to 3.0 µm, and compared with fixed-end isometric reference contractions at 2.5 and 3.0 µm, respectively. Isometric force (2.5 µm) was ∼19% lower in muscle fibres from old as compared with young rats (P&lt;0.001). Upon normalizing to fibre cross-sectional area, there was no age-related difference in specific force (P&gt;0.05). rFD was ∼33% greater in muscle fibres from old as compared with young rats (P&lt;0.05), while rFE did not differ between groups (P&gt;0.05). rFD is amplified in old age at the cellular level, while rFE appears to be unchanged; thus, previously reported age-related modification of rFE occurs upstream from the cellular level.
NARRATIVAS IORUBÁS NA ESCOLA
Authors: Moreira Daniele , Lima Vilela Carolina 
Published: December 2024

No presente artigo, apresentamos o recorte de uma pesquisa maior, cujo objetivo é inserir o uso de narrativas iorubás no currículo de diferentes disciplinas escolares, em uma escola da rede municipal do Rio de Janeiro. Estabelecendo um diálogo entre as práticas docentes e os conceitos de decolonialidade, de Catherine Walsh, e da Pedagogia das Encruzilhadas, de Luiz Rufino, buscamos colaborar para intersecções possíveis entre as tradições escolares e a valorização da diversidade cultural, de forma atenta ao que Azoilda Trindade apresentou como valores civilizatórios afro-brasileiros. Neste artigo, especificamente, descreveremos uma das práticas docentes propostas, que parte de uma abordagem dialógica entre o Itã, que narra a origem dos rios de Obá e de Oxum, Orixás femininas relacionadas às águas, com o conteúdo curricular Revolução Industrial, sugerindo uma análise histórica das suas consequências e das questões ligadas às Ciências da Natureza. Esperamos reforçar a hipótese de que as narrativas da cultura iorubá corroboram para uma pedagogia decolonial e para uma educação comprometida com as relações étnico-raciais, defendendo a abordagem dos saberes ancestrais como um contraponto à visão eurocêntrica do significado de progresso, ressaltando a existência de perspectivas outras de entendimento do mundo, que não apenas a da colonialidade.
Atuação de enfermeiros no teste do coraçãozinho
Authors: Silva Jéssyca Tallyne Dantas de Oliveira , Sobral Priscylla Helena Alencar Falcão , Sousa Hendi Fernandes de , Carvalho Isabella Joyce Silva de Almeida , Oliveira Clara Gabriela Silva de , Lins Larissa Gomes da Silva 
Published: December 2024

Objetivo: analizar la actuación de enfermeros en la realización de la prueba del corazoncito en un hospital de referencia materno-infantil en la mesorregión de São Francisco Pernambucano, Brasil. Método: estudio descriptivo, exploratorio, con enfoque cualitativo, realizado entre septiembre y noviembre de 2022, con 13 enfermeros, mediante aplicación de un cuestionario y entrevistas semiestructuradas, además de la consulta de 229 historiales clínicos, utilizando un instrumento semiestructurado. Los datos fueron almacenados en Microsoft® Office Excel® analizados cuantitativamente con el software R y cualitativamente con el software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires. El Comité de Ética en Investigación aprobó el protocolo de investigación. Resultados: los enfermeros tenían conocimiento teórico sobre la prueba, pero, en la práctica, adoptaron conductas diferentes al protocolo para el tamizaje. Conclusión: se identificaron debilidades en la actuación de los enfermeros relacionadas con el cumplimiento adecuado del protocolo para el tamizaje, el registro de la prueba y los criterios de elegibilidad para la prueba del corazoncito.
Fabrication of a Hollow Non-detachable Cheek Plumper by an Innovative Technique for an Edentulous Patient: Case Report
Authors: Kanojia Ekta Mukesh , Borle Anjali , Sathe Seema , Khubchandani Sheetal 
Published: December 2024

Facial aesthetics are important in both social and professional settings. The replacement of missing teeth should never be the exclusive goal of prosthetic rehabilitation for a patients who has lost all of their teeth. Age-related changes to the face, particularly sagging cheeks, are a worry for total denture patients with high aesthetic demands. Hence, this article outlines a straightforward, rational, reasonably priced, and non-invasive technique for creating a non-detachable cheek plumper for individuals without teeth. Also, the dual-purpose prosthesis not only restores facial aesthetics, but also replaces missing teeth. CPD/Clinical Relevance: A technique for creating a non-detachable cheek plumper for individuals without teeth is described.