White-light endoscopy versus magnifying narrow-band imaging for diagnosis of the histological subtype of gastric cancer
Authors: Kanesaka Takashi , Uedo Noriya , Doyama Hisashi , Yoshida Naohiro , Nagahama Takashi , Otsu Kensei , Uchita Kunihisa , Kojima Koji , Ueo Tetsuya , Takahashi Haruhiko , Ueyama Hiroya , Akazawa Yoichi , Shimokawa Toshio , Yao Kenshi 
Published: September 2020

ABSTRACTObjectiveDistinguishing undifferentiated-type (diffuse-type) from differentiated-type (intestinal-type) cancer is crucial for determining the indication of endoscopic resection for gastric cancer. This study aimed to evaluate on-site diagnostic performance of conventional white-light endoscopy (WLE) and magnifying narrow-band imaging (M-NBI) in determining the subtype of gastric cancer.DesignWe conducted a multicenter prospective single-arm trial. Patients who planned to undergo treatment for histologically proven cT1 gastric cancer were recruited from six tertiary care institutions. The primary and key secondary endpoints were diagnostic accuracy and specificity, respectively. The diagnostic algorithm of WLE was based on lesion color. The M-NBI algorithm was based on the microsurface and microvascular patterns.ResultsA total of 208 patients were enrolled. After protocol endoscopy, 167 gastric cancers were included in the analysis. The accuracy, sensitivity, specificity, and positive likelihood ratio of WLE for undifferentiated-type cancer were 80% (95% CI 73%–86%), 69% (53%–82%), 84% (77%–90%), and 4.4 (2.8–7.0), respectively. Those of M-NBI were 82% (75%–88%), 53% (38%–68%), 93% (87%–97%), and 7.2 (3.6–14.4), respectively. There was no significant difference in accuracy between WLE and M-NBI (p=0.755), but specificity was significantly higher with M-NBI than with WLE (p=0.041). Those of M-NBI combined with WLE were 81% (74%–87%), 38% (24%–54%), 97% (92%–99%), and 11.5 (4.1–32.4), respectively.ConclusionM-NBI is more specific than WLE in distinguishing undifferentiated-type from differentiated-type gastric cancer and M-NBI combined with WLE is highly reliable (positive likelihood ratio >10).Trial registration numberUMIN000032151.Significance of this studyWhat is already known on this subject?➢Distinguishing gastric cancer from non-cancer using endoscopy has already been validated.➢However, distinguishing undifferentiated-type (diffuse-type) from differentiated-type (intestinal-type) cancer is also crucial for determining the indication of endoscopic resection for gastric cancer.➢Several studies have proposed the characteristic findings of the subtype of gastric cancer in white-light endoscopy and magnifying narrow-band imaging.What are the new findings?➢Magnifying narrow-band imaging was more specific than white-light endoscopy in distinguishing undifferentiated-type gastric cancer from differentiated-type gastric cancer.➢The positive likelihood ratio of these combined modalities for undifferentiated-type cancer was highly reliable (>10).➢The present study verified the diagnostic characteristics and potential for clinical use of these two modalities.How might it impact on clinical practice in the foreseeable future?➢This study’s results, which included the positive likelihood ratio, suggest that optical biopsy may be introduced into the decision making of endoscopic treatment for gastric cancer.➢If optical biopsy based on these results is applied, the risk of surgical overtreatment is estimated to be low, leading to practical decision making.