bluuebunny/crossref_metadata_2025_split huggingface dataset:
Division-by-q dichotomization for interval uncertainty reduction by cutting off equal parts from the left and right based on expert judgments under short-termed observations
Authors: Romanuke Vadim 
Published: July 2020

Abstract
A problem of reducing interval uncertainty is considered by an approach of cutting off equal parts from the left and right. The interval contains admissible values of an observed object’s parameter. The object’s parameter cannot be measured directly or deductively computed, so it is estimated by expert judgments. Terms of observations are short, and the object’s statistical data are poor. Thus an algorithm of flexibly reducing interval uncertainty is designed via adjusting the parameter by expert procedures and allowing to control cutting off. While the parameter is adjusted forward, the interval becomes progressively narrowed after every next expert procedure. The narrowing is performed via division-by-q dichotomization cutting off the q
−1-th parts from the left and right. If the current parameter’s value falls outside of the interval, forward adjustment is canceled. Then backward adjustment is executed, where one of the endpoints is moved backwards. Adjustment is not executed when the current parameter’s value enclosed within the interval is simultaneously too close to both left and right endpoints. If the value is “trapped” like that for a definite number of times in succession, the early stop fires.
The Effect of Co-Administration of Inactivated Vaccines Against Bovine Respiratory Disease and Neonatal Calf Diarrhoea
Authors: Makoschey B. , Vertenten G. , Reddick D. 
Published: July 2020

Abstract
A pilot study was performed to evaluate the safety and serological responses after co-administration of two multivalent inactivated vaccines to pregnant cattle. One vaccine was directed against bovine respiratory disease (BRD) and contained antigens of bovine respiratory syncytial virus (BRSV), parainfluenza 3 virus (PI3) and Mannheimia haemolytica (Mh). The second vaccine targeted neonatal calf diarrhoea (NCD) and was composed of inactivated antigens of bovine rotavirus (BRV), bovine coronavirus (BCV) and E. coli. The use of these combinations have been used more and more by veterinary practitioners as there exist some clear evidence that both vaccines improves the passive protection via the colostrum for the relevant pathogens. However, up until now, no safety or efficacy data has been available concerning such co-administrations. The safety of both vaccines and the serological responses to the BRD vaccine has been evaluated when used at the same time, but without mixing and compared to the responses to the administration of each vaccine independently. There was no evidence of any negative effect on calving or calf health in any of the vaccinated animals. The antibody levels against BRSV and Mh in the sera of the calves from cows vaccinated with both vaccines were not significantly different from the levels in the sera of calves vaccinated with the BRD vaccine alone. The results from this pilot study demonstrated that the co-administration of the two multivalent inactivated vaccines had no detrimental effect on the safety or serological responses to the BRD vaccine compared to the independent use of the vaccines.
Gauss and the Mathematical Background to Standardisation
Authors: Ferreirós José 
Published: July 2020

Abstract
Our aim is to explore the links between standardisation, the quantifying spirit, and the discipline mathematics. To do so, we consider the work of Gauss, renowned as a pure mathematician, but professionally an astronomer, and one heavily engaged with all kinds of measuring and precision initiatives. He contributed to the mathematical correction of data with the method of least squares; to observations of high precision in his geodetic work; to the introduction of absolute measures in his collaborations with Weber on terrestrial magnetism; and to the rationalisation of weights and measures in the state of Hannover. Ultimately, the question is to what extent such precision and standardisation activities may have been rooted in the mathematical way of thinking. Mathematics in our tradition has had a strong contemplative bias (theory, theorein in Greek means to contemplate), but it’s a fact that mathematics has always had a non-eliminable technical side.
Co-occurrence of Cell Lines, Basal Media and Supplementation in the Biomedical Research Literature
Authors: Cox Jessica , McBeath Darin , Harper Corey , Daniel Ron 
Published: July 2020

Abstract

Purpose
The use of in vitro cell culture and experimentation is a cornerstone of biomedical research, however, more attention has recently been given to the potential consequences of using such artificial basal medias and undefined supplements. As a first step towards better understanding and measuring the impact these systems have on experimental results, we use text mining to capture typical research practices and trends around cell culture.

Design/methodology/approach
To measure the scale of in vitro cell culture use, we have analyzed a corpus of 94,695 research articles that appear in biomedical research journals published in ScienceDirect from 2000–2018. Central to our investigation is the observation that studies using cell culture describe conditions using the typical sentence structure of cell line, basal media, and supplemented compounds. Here we tag our corpus with a curated list of basal medias and the Cellosaurus ontology using the Aho-Corasick algorithm. We also processed the corpus with Stanford CoreNLP to find nouns that follow the basal media, in an attempt to identify supplements used.

Findings
Interestingly, we find that researchers frequently use DMEM even if a cell line's vendor recommends less concentrated media. We see long-tailed distributions for the usage of media and cell lines, with DMEM and RPMI dominating the media, and HEK293, HEK293T, and HeLa dominating cell lines used.

Research limitations
Our analysis was restricted to documents in ScienceDirect, and our text mining method achieved high recall but low precision and mandated manual inspection of many tokens.

Practical implications
Our findings document current cell culture practices in the biomedical research community, which can be used as a resource for future experimental design.

Originality/value
No other work has taken a text mining approach to surveying cell culture practices in biomedical research.
The Impact of Patents and R&D Cooperation on R&D Investments in a Differentiated Goods Industry
Authors: Karbowski Adam , Prokop Jacek 
Published: July 2020

Abstract
In this paper, we consider the impact of patents and R&D cooperation on R&D investments in the oligopolistic industry with differentiated products. Four types of firms’ conduct are investigated: R&D competition without patents, R&D competition with patent protection, R&D cooperation, and the full industry cooperation. The obtained results suggest that patents do not necessarily promote R&D investments due to the existence of so called tournament effects. R&D cooperation stimulates R&D investments, but R&D cooperation provides sufficient incentives to create a full industry cartel. Such a cartel works to the detriment of consumers. Our analysis led us to the conclusion that for a relatively low level of R&D spillovers, the policy-makers should promote R&D competition without patent protection among oligopolistic firms. For a relatively high level of R&D spillovers, R&D cooperation enhances innovation, but the regulator should monitor the market for probable collusion.
Genetic characterisation of African swine fever virus in outbreaks in Ha Nam province, Red River Delta Region of Vietnam, and activity of antimicrobial products against virus infection in contaminated feed
Authors: Tran Ha Thi Thanh , Truong Anh Duc , Ly Duc Viet , Vu Thi Hao , Hoang Van Tuan , Nguyen Thi Chinh , Chu Thi Nhu , Nguyen Thi Huyen , Pham Ngoc Thi , Nguyen Tinh , Yersin Andrew G. , Dang Hoang Vu 
Published: July 2020

Abstract

Introduction
African swine fever (ASF) was officially reported in Vietnam in February 2019 and spread across the whole country, affecting all 63 provinces and cities.

Material and Methods
In this study, ASF virus (ASFV) VN/Pig/HaNam/2019 (VN/Pig/HN/19) strain was isolated in primary porcine alveolar macrophage (PAM) cells from a sample originating from an outbreak farm in Vietnam’s Red River Delta region. The isolate was characterised using the haemadsorption (HAD) test, real-time PCR, and sequencing. The activity of antimicrobial feed products was evaluated via a contaminated ASFV feed assay.

Results
Phylogenetic analysis of the viral p72 and EP402R genes placed VN/Pig/HN/19 in genotype II and serogroup 8 and related it closely to Eastern European and Chinese strains. Infectious titres of the virus propagated in primary PAMs were 106 HAD50/ml. Our study reports the activity against ASFV VN/Pig/HN/19 strain of antimicrobial Sal CURB RM E Liquid, F2 Dry and K2 Liquid. Our feed assay findings suggest that the antimicrobial RM E Liquid has a strong effect against ASFV replication. These results suggest that among the Sal CURB products, the antimicrobial RM E Liquid may have the most potential as a mitigant feed additive for ASFV infection. Therefore, further studies on the use of antimicrobial Sal CURB RM E Liquid in vivo are required.

Conclusions
Our study demonstrates the threat of ASFV and emphasises the need to control and eradicate it in Vietnam by multiple measures.
European Formalism and Empiriocriticism: Formalism within the International Empiriocritical Movement
Authors: Tchougounnikov Serge 
Published: July 2020

Abstract
This paper argues that Russian Formalism is to be considered a constitutive part of the international empiriocritical movement—Ernst Mach (1838—1916) and Richard Avenarius’s (1843—1896). The conceptual parallelism between Empiriocriticism and Formalism is striking indeed. Thus, the cornerstones of the empiriocritical approach—the concept of series [Reihe] and the concept of elements [Elemente], understood as sensations [Empfindungen]—are plainly recognizable within formalist theories: the notion of ‘series’ (for example, the notion of ‘literary series’ or ‘poetic series’, leading to the famous concept of ‘literariness’, literaturnost’) and the very formalist idea of a necessarily perceptible character of aesthetic form are only two, most famous, examples of this astonishing affinity. Here are some of the most striking convergences between Empiriocriticism and Formalism: the relativity of any knowledge; continuity between knowledge and perception; the pragmatic dominant; the leitmotif of ‘the Unsalvageable Ego’. Besides, the paper seeks to situate Russian Formalism within European Aesthetic German-speaking Formalism. This kind of formalism formulates some basic oppositions correlated to different types of forming being associated with specific means and specific formal devices to affect them. In this context, particular morphological features result in producing particular feelings conceived in the spatial or syntactic perspective. From its German-speaking analogue, Russian Formalism has inherited this relational and spatial definition of feelings and, largely speaking, of emotionality within art. Indeed, both formalisms treat emotion as a ‘non-subjective’, ‘kinetic’, ‘syntactic’ phenomenon located on the surface of aesthetic objects.
Regional Development of Rural Tourism: The Case of the Gorska Hrvatska Region
Authors: Baković Nina 
Published: July 2020

Abstract
An approach to sustainable tourism through clusters is considered an appropriate strategy in less-developed rural areas of tourist-oriented countries, such as Croatia. This paper clarifies the key challenges of the development of tourism clusters in the region of Gorska Hrvatska and provides new data for an approach to sustainable rural tourism development. Using available secondary data from governmental bodies, non-governmental organizations, protected areas of Gorska Hrvatska, and primary data of the Lika Destination Cluster, the paper explores the key challenges of developing a cluster of tourism and selective forms of tourism. Most tourism clusters in Croatia have remained in the first phase of development for years, even though this approach has failed to to achieve significant results. The key benefits of networking and branding in rural areas are identified and defined, but these potentials are still largely underutilized. The objective of this study is to provide practical recommendations to the Croatian tourism industry on how to learn from the suggested best practices and how to implement them effectively. For that purpose, the case of sustainable tourism located in the Gorska Hrvatska region, called the Lika Destination Cluster is analyzed.
An automated nD model creation on BIM models
Authors: Vycital Miroslav , Jarský Cenek 
Published: July 2020

AbstractThe construction technology (CONTEC) method was originally developed for automated CONTEC planning and project management based on the data in the form of a budget or bill of quantities. This article outlines a new approach in an automated creation of the discrete nD building information modeling (BIM) models by using data from the BIM model and their processing by existing CONTEC method through the CONTEC software. This article outlines the discrete modeling approach on BIM models as one of the applicable approaches for nD modeling. It also defines the methodology of interlinking BIM model data and CONTEC software through the classification of items. The interlink enables automation in the production of discrete nD BIM model data, such as schedule (4D) including work distribution end resource planning, budget (5D)—based on integrated pricing system, but also nD data such as health and safety risks (6D) plans (H&S Risk register), quality plans, and quality assurance checklists (7D) including their monitoring and environmental plans (8D). The methodology of the direct application of the selected classification system, as well as means of data transfer and conditions of data transferability, is described. The method was tested on the case study of an office building project, and acquired data were compared to actual construction time and costs. The case study proves the application of the CONTEC method as a usable method in the BIM model environment, enabling the creation of not only 4D, 5D models but also nD discrete models up to 8D models in the perception of the construction management process. In comparison with the existing BIM classification systems, further development of the method will enable full automated discrete nD model creation in the BIM model environment.
The effect of an interdisciplinary Greek traditional dance programme on Middle School students’ goal orientation and anxiety
Authors: Filippou Filippos , Rokka Stella , Pitsi Athina , Koupani Aikaterini , Masadis Grigoris , Karagiannidou Veroniki , Samara Eleni , Varsami Dimitra , Filippou Dafni-Anastasia 
Published: July 2020

Abstract
The aim of the study was to investigate the effect of an interdisciplinary program of Greek folk dance, with topics from history and geography on Middle School students’ goal orientation and anxiety level. The sample consisted of 260 students (134 boys & 126 girls). The experimental group (n=144) followed the interdisciplinary four-week program (two lessons per week) while the control group (n=126) followed the corresponding typical physical education program. For the data collection, the questionnaire used was the “Goal orientation” by Papaioannou, Milosis, Kosmidou, and Tsiggilis (2002) and the Greek version (Kakkos & Zervas, 1996) of “Competitive State Anxiety Inventory-2” (Martens et al., 1990). The students filled in the questionnaires before and after their participating in each program. Descriptive statistics, reliability analysis, and Repeated Measures ANOVA were used. Results showed that a. Cronbach’s alpha was satisfactory. b. Τhe experimental group decreased significantly the levels of “ego-strengthening” and “ego-protection”, and on the contrary significantly increase the “personal development”, and “social acceptance”. c. Experimental group’s boys and girls decreased their “ego-strengthening” and “ego-protection”, and enhanced their “personal development” and “social acceptance” more than their control group peers. d. The experimental group decreased the levels of somatic and cognitive anxieties and increased significantly their self-confidence. e. male students increased their self-confidence more than female students. These findings support the view that an interdisciplinary program of traditional Greek dance with issues from history and geography enable us to reduce the rates of ego-strengthening, ego-protection, somatic and cognitive anxiety while simultaneously increases students’ personal development, social acceptance, and self-confidence
Long-term toxicity and survival outcomes after stereotactic ablative radiotherapy for patients with centrally located thoracic tumors
Authors: Atalar Banu , Mustafayev Teuta Zoto , Sio Terence T. , Sahin Bilgehan , Gungor Gorkem , Aydın Gokhan , Yapici Bulent , Ozyar Enis 
Published: July 2020

Abstract

Background
Stereotactic ablative radiotherapy (SABR) is effective for thoracic cancer and metastases; however, adverse effects are greater for central tumors. We evaluated factors affecting outcomes and toxicities after SABR for patients with primary lung and oligometastatic tumors.

Patients and methods
We retrospectively identified consecutive patients with centrally located lung tumors that were treated at our hospital from 2009-2016. The effects of patient, disease, and treatment-related parameters on local control (LC), overall survival (OS), and toxicity-free survival (TFS) were evaluated with multivariate analyses.

Results
Among 65 consecutive patients identified with 70 centrally located tumors, 20 tumors (28%) were reirradiated. Median (range) total dose for all tumors was 55 (30–60) Gy in 5 (3–10) fractions. Radiographic complete response was obtained in 43 lesions (61%). None of the analyzed factors were correlated with complete response. After a median follow-up of 57 (95% CI, 48–65) months, 10 tumors (14%) relapsed and 37 patients (57%) died; the actuarial 2- and 5-year OS rates were 52% and 28%, respectively. Median OS was significantly lower in patients with grade 3 or higher toxicity vs. lower toxicity (5 vs. 39 months; P < 0.001). Among 17 severe toxicities, 5 were grade 5, and 3 of them were reirradiated to the same field. Grade 3 to 5 TFS was lower with vs. without reirradiation (2-year TFS, 63% vs. 96%; P = 0.02).

Conclusions
Our study showed that modern SABR is effective for central lung tumors, and toxicities are acceptable. SABR for reirradiated central lung lesions and possibly for lesions abutting the tracheobronchial tree may result in higher risk of serious toxicities.
Breast cancer risk based on adapted IBIS prediction model in Slovenian women aged 40–49 years - could it be better?
Authors: Oblak Tjasa , Zadnik Vesna , Krajc Mateja , Lokar Katarina , Zgajnar Janez 
Published: July 2020

Abstract

Background
The aim of the study was to assess the proportion of women that would be classified as at above-average risk of breast cancer based on the 10 year-risk prediction of the Slovenian breast cancer incidence rate (S-IBIS) program in two presumably above-average breast cancer risk populations in age group 40-49 years: (i) women referred for any reason to diagnostic breast centres and (ii) women who were diagnosed with breast cancer aged 40–49 years. Breast cancer is the commonest female cancer in Slovenia, with an incidence rate below European average. The Tyrer-Cuzick breast cancer risk assessment algorithm was recently adapted to S-IBIS. In Slovenia a tailored mammographic screening for women at above average risk in age group 40–49 years is considered in the future. S-IBIS is a possible tool to select population at above-average risk of breast cancer for tailored screening.

Patients and methods
In 357 healthy women aged 40–49 years referred for any reason to diagnostic breast centres and in 367 female breast cancer patients aged 40–49 years at time of diagnosis 10-years breast cancer risk was calculated using the S-IBIS software. The proportion of women classified as above-average risk of breast cancer was calculated for each subgroup of the study population.

Results
48.7% of women in the Breast centre group and 39.2% of patients in the breast cancer group had above-average 10-year breast cancer risk. Positive family history of breast cancer was more prevalent in the Breast centre group (p < 0.05).

Conclusions
Inclusion of additional risk factors into the S-IBIS is warranted in the populations with breast cancer incidence below European average to reliably stratify women into breast cancer risk groups.
Medication use and polypharmacy in patients referred to a tertiary gastroenterology practice
Authors: Chris-Olaiya Abimbola , Palmer William , Stancampiano Fernando , Lacy Brian , Heckman Michael , Chirila Razvan , Nikpour Naveed , Mcleod Ethan , Ryan Taylor , Maillis Alex , Vargas Emily , Bouras Ernest 
Published: July 2020

Abstract

Introduction. Commonly prescribed medications are associated with various gastrointestinal (GI) side effects but few data are available on prescription medication use and polypharmacy in a gastroenterology outpatient practice. We aimed to examine the prevalence of polypharmacy, defined as the simultaneous use of 5 or more medications.

Methods. A descriptive correlational study of consecutive outpatient consultations in 988 patients referred to a tertiary gastroenterology practice. Main outcome measurements were frequency of prescription medication use and polypharmacy.

Results. The most common GI symptoms were abdominal pain (72%), nausea (57%), and constipation (53%). The frequency of polypharmacy was 10%. Eighty percent of patients took at least one medication and 60% took two or more. The most frequently used medication classes were proton pump inhibitors (43%), followed by benzodiazepines (30%), selective serotonin-reuptake or norepinephrine-reuptake inhibitors (28%), non-steroidal anti-inflammatory drugs (27%), and opioids (21%).

Conclusion. There was a higher use of prescription medicine including antidepressants, and a lower frequency of polypharmacy in our study cohort compared to the general population. The use of medications may have contributed to the symptoms leading to our study’s population GI consultation.