bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Combined Strength and Power Training on Physical Performance and Interlimb Asymmetries in Adolescent Female Soccer Players
Authors: Pardos-Mainer Elena , Casajús José Antonio , Bishop Chris , Gonzalo-Skok Oliver 
Published: August 2020

Purpose: To examine the effects of an 8-week combined strength and power training intervention on physical performance and interlimb asymmetries in adolescent female soccer players. Methods: Thirty-seven adolescent female soccer players (age 16.1 [1.1] y) were randomly assigned to a control group (n = 18) or experimental group (n = 19). The experimental group performed combined strength and power training twice a week, which consisted of strength and power exercises that trained the major muscles of the lower body and trunk musculature. Preintervention and postintervention tests included unilateral and bilateral horizontal and countermovement jump tests, a 40-m sprint test (10- and 30-m split times), a 10-m sprint with a 180° change-of-direction (COD) test, and a multiple-COD test (V-cut test). Asymmetries were also analyzed in the unilateral tests. Results: Significant group-by-time interaction of the improvement between pretest and posttest was observed for speed (effect size [ES]: −1.30 to −1.16) and COD tests (ES: −0.62 to −0.61) but not in jumping (ES: −0.09 to 0.28) and interlimb-asymmetry tests (ES: −0.13 to 0.57). Conclusions: The short-term in-season combined strength and power training program induced greater speed and COD performance improvements than soccer training alone in adolescent female soccer players.
The Relationships Between External and Internal Workloads During Basketball Training and Games
Authors: Fox Jordan L. , O’Grady Cody J. , Scanlan Aaron T. 
Published: August 2020

Purpose: To investigate the relationships between external and internal workloads using a comprehensive selection of variables during basketball training and games. Methods: Eight semiprofessional, male basketball players were monitored during training and games for an entire season. External workload was determined as PlayerLoad™: total and high-intensity accelerations, decelerations, changes of direction, and jumps and total low-intensity, medium-intensity, high-intensity, and overall inertial movement analysis events. Internal workload was determined using the summated-heart-rate zones and session rating of perceived exertion models. The relationships between external and internal workload variables were separately calculated for training and games using repeated-measures correlations with 95% confidence intervals. Results: PlayerLoad was more strongly related to summated-heart-rate zones (r = .88 ± .03, very large [training]; r = .69 ± .09, large [games]) and session rating of perceived exertion (r = .74 ± .06, very large [training]; r = .53 ± .12, large [games]) than other external workload variables (P < .05). Correlations between total and high-intensity accelerations, decelerations, changes of direction, and jumps and total low-intensity, medium-intensity, high-intensity, and overall inertial movement analysis events and internal workloads were stronger during training (r = .44–.88) than during games (r = .15–.69). Conclusions: PlayerLoad and summated-heart-rate zones possess the strongest dose–response relationship among a comprehensive selection of external and internal workload variables in basketball, particularly during training sessions compared with games. Basketball practitioners may therefore be able to best anticipate player responses when prescribing training drills using these variables for optimal workload management across the season.
Training Load and Performance Impairments in Professional Cyclists During COVID-19 Lockdown
Authors: Muriel Xabier , Courel-Ibáñez Javier , Cerezuela-Espejo Victor , Pallarés Jesús G. 
Published: August 2020

Purpose: The COVID-19 outbreak has challenged professional athletes’ training and competition routines in a way not seen before. This report aims to inform about the changes in training volume and intensity distribution and their effects on functional performance due to a 7-week home-confinement period in professional road cyclists from a Union Cycliste Internationale Pro Team. Methods: A total of 18 male professional cyclists (mean [SD] age = 24.9 [2.8] y, body mass = 66.5 [5.6] kg, maximal aerobic power = 449 [39] W; 6.8 [0.6] W/kg) were monitored during the 10 weeks before the lockdown (outdoor cycling) and the 7-week lockdown (indoor cycling turbo trainer). Data from the mean maximal power output (in watts per kilogram) produced during the best 5-minute and best 20-minute records and the training intensity distributions (weekly volumes at power-based training zones) were collected from WKO5 software. Results: Total training volume decreased 33.9% during the lockdown (P < .01). Weekly volumes by standardized zones (Z1 to Z6) declined between 25.8% and 52.2% (effect size from 0.83 to 1.57), except for Z2 (P = .38). There were large reductions in best 5-minute and best 20-minute performance (effect size > 1.36; P < .001) with losses between 1% and 19% in all the cyclists. Conclusions: Total indoor volumes of 12 hours per week, with 6 hours per week at low intensity (Z1 and Z2) and 2 hours per week at high intensity over the threshold (Z5 and Z6), were insufficient to maintain performance in elite road cyclists during the COVID-19 lockdown. Such performance declines should be considered to enable a safe and effective return to competition.
Antibiotic Consumption and Stewardship at a Hospital outside of an Early Coronavirus Disease 2019 Epicenter
Authors: Buehrle Deanna J. , Decker Brooke K. , Wagener Marilyn M. , Adalja Amesh , Singh Nina , McEllistrem Mary C. , Nguyen M. Hong , Clancy Cornelius J. 
Published: August 2020

There are scant data on the impact of coronavirus disease 2019 (COVID-19) on hospital antibiotic consumption, and no data from outside epicenters. At our nonepicenter hospital, antibiotic days of therapy (DOT) and bed days of care (BDOC) were reduced by 151.5/month and 285/month, respectively, for March to June 2020 compared to 2018–2019 (
P =
0.001 and
P <
0.001). DOT per 1,000 BDOC was increased (8.1/month;
P =
0.
Regulation of Sporangium Formation, Spore Dormancy, and Sporangium Dehiscence by a Hybrid Sensor Histidine Kinase inActinoplanes missouriensis: Relationship with the Global Transcriptional Regulator TcrA
Authors: Hashiguchi Yuichiro , Tezuka Takeaki , Mouri Yoshihiro , Konishi Kenji , Fujita Azusa , Hirata Aiko , Ohnishi Yasuo 
Published: August 2020

ABSTRACTThe rare actinomyceteActinoplanes missouriensisforms terminal sporangia containing a few hundred flagellated spores. In response to water, the sporangia open and release the spores into external environments. The orphan response regulator TcrA functions as a global transcriptional activator during sporangium formation and dehiscence. Here, we report the characterization of an orphan hybrid histidine kinase, HhkA. Sporangia of anhhkAdeletion mutant contained many distorted or ectopically germinated spores and scarcely opened to release the spores under sporangium dehiscence-inducing conditions. These phenotypic changes are quite similar to those observed in atcrAdeletion mutant. Comparative RNA sequencing analysis showed that genes controlled by HhkA mostly overlap TcrA-regulated genes. The direct interaction between HhkA and TcrA was suggested by a bacterial two-hybrid assay, but this was not conclusive. The phosphorylation of TcrA using acetyl phosphate as a phosphate donor markedly enhanced its affinity for the TcrA box sequences in the electrophoretic mobility shift assay. Taking these observations together with other results, we proposed that HhkA and TcrA compose a cognate two-component regulatory system, which controls the transcription of the genes involved in many aspects of morphological development, including sporangium formation, spore dormancy, and sporangium dehiscence inA. missouriensis.IMPORTANCEActinoplanes missouriensisgoes through complex morphological differentiation, including formation of flagellated spore-containing sporangia, sporangium dehiscence, swimming of zoospores, and germination of zoospores to filamentous growth. Although the orphan response regulator TcrA globally activates many genes required for sporangium formation, spore dormancy, and sporangium dehiscence, its partner histidine kinase remained unknown. Here, we analyzed the function of an orphan hybrid histidine kinase, HhkA, and proposed that HhkA constitutes a cognate two-component regulatory system with TcrA. That HhkA and TcrA homologues are highly conserved among the genusActinoplanesand several closely related rare actinomycetes indicates that this possible two-component regulatory system is employed for complex morphological development in sporangium- and/or zoospore-forming rare actinomycetes.
Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomised, non-inferiority clinical trial (OB12)
Authors: Sanz-Cuesta Teresa , Escortell-Mayor Esperanza , Cura-Gonzalez Isabel , Martin-Fernandez Jesus , Riesgo-Fuertes Rosario , Garrido-Elustondo Sofía , Mariño-Suárez Jose Enrique , Álvarez-Villalba Mar , Gómez-Gascón Tomás , González-García Inmaculada , González-Escobar Paloma , Vargas-Machuca Cabañero Concepción , Noguerol-Álvarez Mar , García de Blas-González Francisca , Baños-Morras Raquel , Díaz-Laso Concepción , Caballero-Ramírez Nuria , Herrero de-Dios Alicia , Fernández-García Rosa , Herrero-Hernández Jesús , Pose-García Belen , Sevillano-Palmero María Luisa , Mateo-Ruiz Carmen , Medina-Bustillo Beatriz , Aguilar-Jiménez Monica 
Published: August 2020

ObjectivesTo compare the effectiveness of oral versus intramuscular (IM) vitamin B12 (VB12) in patients aged ≥65 years with VB12 deficiency.DesignPragmatic, randomised, non-inferiority, multicentre trial in 22 primary healthcare centres in Madrid (Spain).Participants283 patients ≥65 years with VB12 deficiency were randomly assigned to oral (n=140) or IM (n=143) treatment arm.InterventionsThe IM arm received 1 mg VB12 on alternate days in weeks 1–2, 1 mg/week in weeks 3–8 and 1 mg/month in weeks 9–52. The oral arm received 1 mg/day in weeks 1–8 and 1 mg/week in weeks 9–52.Main outcomesSerum VB12 concentration normalisation (≥211 pg/mL) at 8, 26 and 52 weeks. Non-inferiority would be declared if the difference between arms is 10% or less. Secondary outcomes included symptoms, adverse events, adherence to treatment, quality of life, patient preferences and satisfaction.ResultsThe follow-up period (52 weeks) was completed by 229 patients (80.9%). At week 8, the percentage of patients in each arm who achieved normal B12 levels was well above 90%; the differences in this percentage between the oral and IM arm were −0.7% (133 out of 135 vs 129 out of 130; 95% CI: −3.2 to 1.8; p>0.999) by per-protocol (PPT) analysis and 4.8% (133 out of 140 vs 129 out of 143; 95% CI: −1.3 to 10.9; p=0.124) by intention-to-treat (ITT) analysis. At week 52, the percentage of patients who achieved normal B12 levels was 73.6% in the oral arm and 80.4% in the IM arm; these differences were −6.3% (103 out of 112 vs 115 out of 117; 95% CI: −11.9 to −0.1; p=0.025) and −6.8% (103 out of 140 vs 115 out of 143; 95% CI: −16.6 to 2.9; p=0.171), respectively. Factors affecting the success rate at week 52 were age, OR=0.95 (95% CI: 0.91 to 0.99) and having reached VB12 levels ≥281 pg/mL at week 8, OR=8.1 (95% CI: 2.4 to 27.3). Under a Bayesian framework, non-inferiority probabilities (Δ>−10%) at week 52 were 0.036 (PPT) and 0.060 (ITT). Quality of life and adverse effects were comparable across groups. 83.4% of patients preferred the oral route.ConclusionsOral administration was no less effective than IM administration at 8 weeks. Although differences were found between administration routes at week 52, the probability that the differences were below the non-inferiority threshold was very low.Trial registration numbersNCT 01476007; EUDRACT (2010-024129-20).
SAFety, Effectiveness of care and Resource use among Australian Hospitals (SAFER Hospitals): a protocol for a population-wide cohort study of outcomes of hospital care
Authors: Ranasinghe Isuru , Hossain Sadia , Ali Anna , Horton Dennis , Adams Robert JT , Aliprandi-Costa Bernadette , Bertilone Christina , Carneiro Gustavo , Gallagher Martin , Guthridge Steven , Kaambwa Billingsley , Kotwal Sradha , O'Callaghan Gerry , Scott Ian A , Visvanathan Renuka , Woodman Richard J 
Published: August 2020

IntroductionDespite global concerns about the safety and quality of health care, population-wide studies of hospital outcomes are uncommon. The SAFety, Effectiveness of care and Resource use among Australian Hospitals (SAFER Hospitals) study seeks to estimate the incidence of serious adverse events, mortality, unplanned rehospitalisations and direct costs following hospital encounters using nationwide data, and to assess the variation and trends in these outcomes.Methods and analysisSAFER Hospitals is a cohort study with retrospective and prospective components. The retrospective component uses data from 2012 to 2018 on all hospitalised patients age ≥18 years included in each State and Territories’ Admitted Patient Collections. These routinely collected datasets record every hospital encounter from all public and most private hospitals using a standardised set of variables including patient demographics, primary and secondary diagnoses, procedures and patient status at discharge. The study outcomes are deaths, adverse events, readmissions and emergency care visits. Hospitalisation data will be linked to subsequent hospitalisations and each region’s Emergency Department Data Collections and Death Registries to assess readmissions, emergency care encounters and deaths after discharge. Direct hospital costs associated with adverse outcomes will be estimated using data from the National Cost Data Collection. Variation in these outcomes among hospitals will be assessed adjusting for differences in hospitals’ case-mix. The prospective component of the study will evaluate the temporal change in outcomes every 4 years from 2019 until 2030.Ethics and disseminationHuman Research Ethics Committees of the respective Australian states and territories provided ethical approval to conduct this study. A waiver of informed consent was granted for the use of de-identified patient data. Study findings will be disseminated via presentations at conferences and publications in peer-reviewed journals.
High-resolution spatiotemporal measurement of air and environmental noise pollution in Sub-Saharan African cities: Pathways to Equitable Health Cities Study protocol for Accra, Ghana
Authors: Clark Sierra N , Alli Abosede S , Brauer Michael , Ezzati Majid , Baumgartner Jill , Toledano Mireille B , Hughes Allison F , Nimo James , Bedford Moses Josephine , Terkpertey Solomon , Vallarino Jose , Agyei-Mensah Samuel , Agyemang Ernest , Nathvani Ricky , Muller Emily , Bennett James , Wang Jiayuan , Beddows Andrew , Kelly Frank , Barratt Benjamin , Beevers Sean , Arku Raphael E 
Published: August 2020

IntroductionAir and noise pollution are emerging environmental health hazards in African cities, with potentially complex spatial and temporal patterns. Limited local data are a barrier to the formulation and evaluation of policies to reduce air and noise pollution.Methods and analysisWe designed a year-long measurement campaign to characterise air and noise pollution and their sources at high-resolution within the Greater Accra Metropolitan Area (GAMA), Ghana. Our design uses a combination of fixed (year-long, n=10) and rotating (week-long, n =~130) sites, selected to represent a range of land uses and source influences (eg, background, road traffic, commercial, industrial and residential areas, and various neighbourhood socioeconomic classes). We will collect data on fine particulate matter (PM2.5), nitrogen oxides (NOx), weather variables, sound (noise level and audio) along with street-level time-lapse images. We deploy low-cost, low-power, lightweight monitoring devices that are robust, socially unobtrusive, and able to function in Sub-Saharan African (SSA) climate. We will use state-of-the-art methods, including spatial statistics, deep/machine learning, and processed-based emissions modelling, to capture highly resolved temporal and spatial variations in pollution levels across the GAMA and to identify their potential sources. This protocol can serve as a prototype for other SSA cities.Ethics and disseminationThis environmental study was deemed exempt from full ethics review at Imperial College London and the University of Massachusetts Amherst; it was approved by the University of Ghana Ethics Committee (ECH 149/18-19). This protocol is designed to be implementable in SSA cities to map environmental pollution to inform urban planning decisions to reduce health harming exposures to air and noise pollution. It will be disseminated through local stakeholder engagement (public and private sectors), peer-reviewed publications, contribution to policy documents, media, and conference presentations.
Comparing two dry needling interventions for plantar heel pain: a randomised controlled trial
Authors: Al-Boloushi Zaid , Gómez-Trullén Eva Maria , Arian Mohammad , Fernández Daniel , Herrero Pablo , Bellosta-López Pablo 
Published: August 2020

ObjectivesTo compare the effectiveness of dry needling (DN) versus percutaneous needle electrolysis (PNE) for improving the level of pain, function and quality of life (QoL) of patients suffering from plantar heel pain (PHP) provoked by myofascial trigger points.DesignA prospective, parallel-group, randomised controlled trial with blinded outcome assessment.SettingA single treatment facility in the State of Kuwait.Participants118 participants were screened for eligibility. Of these, 102 participants were enrolled (30 men (49.5±8.9 years) and 72 women (48.1±8.8 years)) and 68 of them completed the trial.InterventionsTwo parallel groups, one study arm received DN and a stretching protocol whereas the other arm received percutaneous needling electrolysis with a stretching protocol.Primary and secondary outcome measuresThe primary outcome measure was the Foot Pain domain of the Foot Health Status Questionnaire, with 13 questions related to foot health-related domains. Secondary outcome measures included the 0–10 numerical rating scale pain visual analogue scale (VAS) scores, performed before and after each treatment session. In addition, QoL was measured using the EuroQoL-5 dimensions. All measurements were taken at baseline, at 4, 8, 12, 26 and 52 weeks.ResultsFoot Pain domain improved at all time points for DN group (p<0.001; 29.7 (17.8 to 41.5)) and percutaneous needling electrolysis group (p<0.001; 32.7 (18.3 to 47.0)), without significant differences between groups. Pain VAS scores decreased at all time points for both DN (p<0.001; −2.6 (−4.0 to −1.2)) and percutaneous needling electrolysis group (p<0.001; −3.0 (−4.5 to −1.6)). QoL improved at 4 weeks for both DN (p<0.01; 0.15 (0.5 to 0.25)) and percutaneous needling electrolysis group (p<0.01; 0.09 (0.01 to 0.17)) and at 8 and 52 weeks for the PNE group (p<0.01; 0.10 (0.02 to 0.18)), with significant differences between groups for the QoL at 52 weeks (p<0.05; 0.10 (0.01 to 0.18)). There were two small haematomas in the PNE group and one in the DN group. No serious adverse events were reported.ConclusionsBoth PNE and DN were effective for PHP management, reducing mean and maximum pain since the first treatment session, with long lasting effects (52 weeks) and significant differences between groups in the case of QoL at 52 weeks in favour of the PNE group.Trial registration numberNCT03236779.
Multimorbidity and patient-reported diagnostic errors in the primary care setting: multicentre cross-sectional study in Japan
Authors: Aoki Takuya , Watanuki Satoshi 
Published: August 2020

ObjectivesThere is lack of evidence for the association between multimorbidity and diagnostic errors. Information on diagnostic errors from patients’ perspectives is crucial to improve the diagnostic process. In this study, we aimed to investigate patient-reported diagnostic errors and to examine the relationship between multimorbidity and patient-reported diagnostic errors in the primary care setting.DesignMulticentre cross-sectional study.SettingA primary care practice-based research network in Japan (25 primary care facilities).ParticipantsAdult outpatients filled out a standardised questionnaire.Primary outcome measurePatient-reported diagnostic errors.ResultsData collected from 1474 primary care outpatients were analysed. The number of participants who reported diagnostic errors was 57 (3.9%). Most of the missed diagnoses were common conditions in primary care, such as cancer, dermatitis and hypertension. After adjustment for possible confounders and clustering within facilities, multimorbidity was positively associated with patient-reported diagnostic errors (adjusted OR=1.83, 95% CI 1.01 to 3.31). The results of the sensitivity analysis were consistent with those of the primary analysis.ConclusionsThe present study showed a lower proportion of patients reporting experiences of diagnostic errors in primary care than those reported in previous studies in other countries. However, patients with multimorbidity are more likely to report diagnostic errors in primary care; thus, further research is necessary to improve the diagnostic process for patients with multimorbidity.