bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADCs, as Novel Revolutionary Weapons for Providing a Step Forward in Targeted Therapy of Malignancies
Authors: Amani Nooshafarin , Dorkoosh Farid Abedin , Mobedi Hamid 
Published: November 2019

:Antibody drug conjugates (ADCs), as potent pharmaceutical trojan horses for cancer treatment, provide superior efficacy and specific targeting along with low risk of adverse reactions compared to traditional chemotherapeutics. In fact, the development of these agents combines the selective targeting capability of monoclonal antibody (mAb) with high cytotoxicity of chemotherapeutics for controlling the neoplastic mass growth. Different ADCs (more than 60 ADCs) in preclinical and clinical trials were introduced in this novel pharmaceutical field. Various design-based factors must be taken into account for improving the functionality of ADC technology, including selection of appropriate target antigen and high binding affinity of fragment (miniaturized ADCs) or full mAbs (preferentially use of humanized or fully human antibodies compared to murine and chimeric ones), use of bispecific antibodies for dual targeting effect, linker engineering and conjugation method efficacy to obtain more controlled drug to antibody ratio (DAR). Challenging issues affecting therapeutic efficacy and safety of ADCs, including bystander effect, on- and off-target toxicities, multi drug resistance (MDR) are also addressed. 4 FDA-approved ADCs in the market, including ADCETRIS ®, MYLOTARG®, BESPONSA ®, KADCYLA®. The goal of the current review is to evaluate the key parameters affecting ADCs development.
Atomic Force Microscopy: The Characterisation of Amyloid Protein Structure in Pathology
Authors: Visser Maria J.E. , Pretorius Etheresia 
Published: November 2019

:
Proteins are versatile macromolecules that perform a variety of functions and participate in
virtually all cellular processes. The functionality of a protein greatly depends on its structure and alterations
may result in the development of diseases. Most well-known of these are protein misfolding disorders,
which include Alzheimer’s and Parkinson’s diseases as well as type 2 diabetes mellitus, where
soluble proteins transition into insoluble amyloid fibrils. Atomic Force Microscopy (AFM) is capable of
providing a topographical map of the protein and/or its aggregates, as well as probing the nanomechanical
properties of a sample. Moreover, AFM requires relatively simple sample preparation, which presents
the possibility of combining this technique with other research modalities, such as confocal laser
scanning microscopy, Raman spectroscopy and stimulated emission depletion microscopy. In this review,
the basic principles of AFM are discussed, followed by a brief overview of how it has been applied
in biological research. Finally, we focus specifically on its use as a characterisation method to
study protein structure at the nanoscale in pathophysiological conditions, considering both molecules
implicated in disease pathogenesis and the plasma protein fibrinogen. In conclusion, AFM is a userfriendly
tool that supplies multi-parametric data, rendering it a most valuable technique.
Dickkopf-1 and β-catenin as Biomarkers for Early Diagnosis of Hepatocellular Carcinoma
Authors: Mohamed Amal A. , Ghanem Hala M. , Kamal Maha M. , Ahmed Rehab , Madkour Naglaa K. , Abdou Dina , Talima Soha M. , Hawash Nehad , Abd-Elsalam Sherief 
Published: November 2019

Background &Aims:
The clinical value of alpha-fetoprotein (AFP) as a marker to
detect early hepatocellular carcinoma (HCC) has been questioned owing to its low sensitivity and
specificity. The purpose of this work was to investigate whether serum Wnt/β-catenin and DKK1
levels in chronic hepatitis C patients could be used as early predictors for the risk of HCC
development.

Methods:
The study was conducted on 37 healthy controls, and 150 CHC patients were divided
into three groups: CHC, liver cirrhosis (LC), and HCC patients. AFP, AFP-L3, β-catenin, and
DKK-1 were assayed by ELISA.

Results:
Both β-catenin and DKK1 levels significantly increased (p < 0.001) in the HCC group in
comparison to LC and CHC groups. The first cut-off value for DKK-1 was 253 pg/ml with 88%
sensitivity and 86% specificity. The second was 301.5 pg/ml with 82 percent sensitivity and
100% specificity. The β-catenin cut-off value was 7.35 ng/ml with 80% sensitivity and 74%
specificity. A positive correlation was observed between DKK-1 and β-catenin (r=0.491), DKK-1
and tumor size (r =0.616), and β-catenin and tumor size (r =0.472).

Conclusion:
DKK-1 and β-catenin may serve as predictors for the progression of CHC and LC
into HCC.
Different Medical Image Registration Techniques: A Comparative Analysis
Authors: Karthick Suyambu , Maniraj S. 
Published: November 2019

Background:
Image registration provides major role in real world applications and classic
digital image processing. Image registration is carried out for more than one image and this image
was captured from a different location, different sensors, different time and different viewpoints.

Discussion:
This paper deals with the comparative analysis of various registration techniques and
here six registration techniques depending upon intensity, phase correlation, image feature, area,
control points and mutual information are compared. Comparative analysis for different methodologies
shows the advantages of one method over the other methods. The foremost objective of this
paper is to deliver a complete reference source for the scholars interested in registration, irrespective
of specific application extents.

Conclusion:
Finally performance analyses are evaluated for the medical datasets and comparison is
graphically shown with the MATLAB simulation tool.
Chiral Separation of Oxomemazine Enantiomers by HPLC Technique and Enantiomeric Separation Mechanism via Docking Studies
Authors: Raikar Prachi , Gurupadayya Bannimath , Mandal Subhankar P. , Reddy Maruthi , Prabhakar Prabitha 
Published: November 2019

Background:
A normal phase- High Performance Liquid Chromatographic (HPLC) method
was developed for the enantioseparation of Oxomemazine.

Methods:
Separation of enantiomers was attained on Amylose Tris (5-chloro-2-methylphenylcarbamate)
using n-hexane: Iso-propyl Alcohol (IPA): Diethylamine (DEA) (60: 40: 0.1) as the
mobile phase and the peaks were observed at 227nm using PDA detector. The run time of the analysis
was set to 30 min.

Results:
Linearity was found in the range 10-50 μgmL-1. The enantiomers were separated at retention
times 16.87 min and 21.37 min.

Conclusion:
The developed method was validated as per the ICH guidelines, thus proving the method
to be selective, precise and showing linear response of Oxomemazine peak areas. Additionally, the
method of chiral separation was being understood by docking simulation study. The method was appropriate
for analysis of Oxomemazine in the pure form and its formulation.
Sleep and Sleep Disorders in Tourette Syndrome: What is Known and What is Still Unknown
Authors: Oksenberg Arie 
Published: November 2019

Background:Most of the patients with Tourette Syndrome (TS) present additional comorbidities. Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are the most common. Sleep Disorder has been suggested also as common comorbidity.Objective:To review the literature on sleep characteristics and sleep disorder in patients with Tourette Syndrome (TS), with emphasis on the contribution of specific co-morbidities to the severity of impaired sleep and life quality of the patients.Results:In general, sleep problems are not frequent at the age when tics appear which are estimated to affect about 10 % of these children. In severe cases, tics appear in all sleep stages. In a large study, the prevalence of sleep problems was 17.8% but was 12 % in “TS-only” (9.4% in children and 7.5 in adults) compared to 22% in children and 18% in adults with TS+ADHD. Unfortunately, in most of the studies, the characteristics of these “sleep problems” are not defined. In spite of the scarcity of data, the two main sleep disorders in TS patients are insomnia and parasomnias. Although much more data is needed, many TS subjects are sleep deprived (which exacerbate the tics) and may suffer from excessive daytime sleepiness, which negatively affects normal functioning.Conclusions:Although the literature is not conclusive, children and adolescents with TS appear to suffer more from sleep disturbances and sleep disorders than age-matched controls. Not all patients have tics during sleep, but in severe cases, tics may appear in all sleep stages. It is clear that when patients present both TS and ADHD, (a very common condition), the sleep difficulties are related mainly to ADHD. Much more research is warranted in all aspects of sleep and sleep disorders in TS.
Design, Synthesis and Evaluation of Novel Substituted (5-methyl-1H-pyrazol-3-yl)- 1,3,4-oxadiazole as Potent Androgen Receptor Antagonist
Authors: Andavar Sasikumar , Vaithilingam Mohanasrinivasan , Selvaraj Divakar , Kumaran Ajeeshkumar A. , Devanathan Krishnaswamy 
Published: November 2019

Background:
Androgen Receptor (AR) is one of the highly explored targets for the treatment of
prostate cancer. The emergence of point mutation in the Ligand Binding Domain (LBD) of AR has resulted in
the development of resistance against AR antagonist. The point mutation T877A, W741L and F876L confer
resistance to flutamide, bicalutamide and enzalutamide respectively. There is no AR antagonist in the present
clinical set up without resistance. Hence, our aim in this study is to design a novel molecule to overcome the
resistance caused by point mutation.

Methods:
Here, we developed novel AR antagonist bearing (5-methyl-1H-pyrazol-3-yl)-1, 3,4-oxadiazole core
by rational drug design. The test molecules 8a-h were synthesized from the corresponding dihydrazide compounds
7a-h on treatment with phosphorous oxychloride on reflux conditions. The structure of the molecules
was confirmed from spectral data such as IR, 1H-NMR, HRMS and 13C-NMR. The synthesized compounds were
screened for cytotoxicity in prostate cancer cell lines LNCaP-FGC and PC3. The confirmation of AR mediated
activity of the test compounds was confirmed by gene expression study. The interaction of the best active
ligands with mutant AR was predicted and drug design was rationalized through docking studies.

Results:
The test compounds 8a-h were synthesized and the structures were conformed using suitable techniques
like IR, 1H-NMR, HRMS and 13C-NMR. Among the tested compounds, 8b and 8d showed potent antiproliferative
activity against mutant AR cell lines. Further, these compounds significantly decreased the gene
expression of prostate cancer biomarkers.

Conclusion:
In this study, we have identified a potential hit molecule for AR antagonism that could be further
developed to obtain a potent clinical candidate.
Response Surface Methodology Towards Optimization of Calotropis Procera Essential Oil Extraction by Using Supercritical CO2
Authors: Zaeri Hossein , Moghadas Bahareh Kamyab , Honarvar Bijan , Rad Ali Shokuhi 
Published: November 2019

Aim:In this research, we aim to investigation on the extraction of essential oil from Calotropis Procera with the family name of Asclepiadaceae, by supercritical carbon dioxide (CO2) solvent.Objective:The comparison of the yield and chemical profile of the extracts achieved by this method with those resulted by the conventional Hydro distillation method.Methods:The extraction experiments were carried out in a bench-scale SC-CO2unit. The effects of temperature, pressure, and extraction time on the oil yield are considered for investigation. The Response Surface Methodology (RSM) with Central Composite Design (CCD) was employed to optimize the process parameters of CO2supercritical extraction (SCE) of the Calotropis Procera. In this experimental design, the design was required 19 experiments with eight (23) factorial points and five replications of the center.Results:Results showed that the data were sufficiently fitted into the second-order polynomial model. The extraction conditions, including pressure, temperature, and extraction time, were studied between 150-200 bar, 40-50 ºC, and 50-100 min, respectively.Conclusion:The optimal conditions are achieved as the temperature of 47.19ºC, the pressure of 172.2 bar, and time of 86 minutes with the retrieval rate of 31.39%.
Exploring the Determinants of Mobile Health Adoption by Hospitals in China: Empirical Study
Authors: Ramdani Boumediene , Duan Binheng , Berrou Ilhem 
Published: November 2019

Background
Although mobile health (mHealth) has the potential to transform health care by delivering better outcomes at a much lower cost than traditional health care services, little is known about mHealth adoption by hospitals.

Objective
This study aims to explore the determinants of mHealth adoption by hospitals using the technology-organization-environment (TOE) framework.

Methods
We conducted an interviewer-administered survey with 87 managers in Chinese public hospitals and analyzed the data using logistic regression.

Results
The results of our survey indicate that perceived ease of use (β=.692; P<.002), system security (β=.473; P<.05), top management support (β=1.466; P<.002), hospital size (β=1.069; P<.004), and external pressure (β=.703; P<.005) are significantly related to hospitals’ adoption of mHealth. However, information technology infrastructure (β=.574; P<.02), system reliability (β=−1.291; P<.01), and government policy (β=2.010; P<.04) are significant but negatively related to hospitals’ adoption of mHealth.

Conclusions
We found that TOE model works in the context of mHealth adoption by hospitals. In addition to technological predictors, organizational and environmental predictors are critical for explaining mHealth adoption by Chinese hospitals.
Daily Patronage Politics: A Village Chief’s Route to Power
Authors: Cahyati Devy Dhian , Luter Lopo Yonatan Hans 
Published: November 2019

This article discusses the politics of patronage used by incumbents in contesting village chief elections. Through observations and interviews conducted before and after the 2018 village chief elections in Klangor Village, Galur District, Kulon Progo Regency, the researchers explored the strategies used by the incumbent to contest the election and seek re-election. At the village level, the politics of patronage function differently than at higher levels of government. The authors argue that incumbents do not only create patronage networks during elections, during which voters are provide money or other gifts; they create patronage networks during their everyday activities. Using the economic resources available to them, incumbents combine three approaches to patronage: benevolence politics, scare-off tactics, and money politics. In this article, the authors argue that the incumbent redefined money, transforming it from a means of conducting transactions into a means of appreciating and rewarding voters. By using this strategy, incumbents can guarantee supporters’ loyalty and receive their votes.
Cuidado perdido de enfermería. Estado del arte para la gestión de los servicios de salud
Authors: Zárate-Grajales R.A. , Mejías M. 
Published: November 2019

El cuidado perdido de enfermería es un fenómeno recientemente explorado que afecta la seguridad de los pacientes, la calidad de la atención y cuestiona la actuación de los profesionales de enfermería.
Objetivo: Conocer el Estado del Arte del tema Cuidado perdido en Enfermería a partir de artículos publicados durante el periodo marzo 2012- marzo 2018.
Metodología: Se realizó una investigación documental a través del sistema de búsqueda PUBMED, con las siguientes palabras clave: missed nursing care, misscare AND care nurse. Se seleccionaron 47 artículos de investigación en idioma inglés y español. Posterior al análisis de contenido de los artículos, los resultados se agruparon en categorías.
Resultados: Se identificaron las siguientes categorías: país donde se realizó la investigación, unidades de atención, tipo de estudio, muestra estudiada, instrumento empleado, marco conceptual, así como los elementos, razones y predictores del cuidado perdido.
Conclusiones: El estudio del fenómeno puede ser un insumo para la toma de decisiones en políticas de salud y en el diseño de estrategias e intervenciones que contribuyan a la mejora del cuidado en las instituciones de salud. La revisión del fenómeno y el análisis permitirán a los interesados en el tema, profundizar en el cuidado perdido e identificar la fundamentación teórica, los elementos conceptuales y los resultados encontrados, los cuales serán aportes para la toma de decisiones en los procesos de mejora, la docencia, el cuidado y la investigación.
QSTE420TM Çeliğinin TIG Kaynak Yöntemiyle Kaynak Edilmesinde İlave Metal Tel Çapının Metalurjik ve Mekanik Özelliklere Etkisinin Belirlenmesi
Authors: HARMAN Mustafa , ADA Hakan , ÇETİNKAYA Cemil 
Published: November 2019

Bu
çalışmada; savunma sanayi, otomotiv sanayi, petrol iletim hatları gibi
sektörlerde yaygın olarak kullanılan ince taneli ve mikro alaşımlı yapıya sahip
QSTE 420TM kalitesindeki çelik sac plaka malzeme, Tungsten Inert Gaz Kaynağı
yönteminde 1,6 mm ve 2,0 mm çapında ilave metal tel kullanılarak ayrı ayrı
birleştirilmiştir. Farklı çaplardaki dolgu tellerine farklı ısı girdileri
uygulanmıştır. Böylece kaynak bölgesi (ana malzeme, ısının tesiri altındaki
bölge ve kaynak metali) üzerinde meydana
gelen mekanik ve metalürjik değişiklikler, çekme, eğme, çentik - darbe, sertlik
testleri ve makrografik, mikrografik muayeneler yapılarak incelenmiştir. Gerçekleştirilen
testler sonucunda; 1,6 mm ilave telin, kaynaklı birleştirmenin kendinden
beklenen mekanik ve metalürjik özellikleri sağladığı gözlenmiştir. % 44 daha
yüksek ısı girdisinin uygulandığı 2,0 mm ilave tel ile yapılan kaynaklı
birleştirmelere ait çekme testlerinde ise kaynak metalinden kopma
gerçekleşmiştir. Bu sonuçlarla QSTE420TM gibi malzemelerde yüksek ısı
girdisinin mekanik ve metalurjik özelliklere olan olumsuz etkileri de
incelenmiştir.
PERILAKU PEDAGANG DAN KONSEP BAI’I MABRUR DALAM FIQIH MUAMALAH
Authors: Muzan Amrul 
Published: November 2019

Kata mabrûr lebih familiar di Indonesia digunakan pada kata haji, padahal kata ini juga digunakan secara luas untuk kata yang lainnya, seperti kepada orang tua, dalam berjanji, juga dalam transaksi jual beli. Kata ini dalam hadits menggunakan kata bai’i mabrûr. Jual beli adalah kegiatan mutlak yang tidak bisa dihindarkan oleh manusia. Jual beli berkaitan dengan usaha memenuhi kebutuhan, baik pribadi, keluarga, dan lainnya. Jual beli juga berkaitan dengan usaha untuk memperoleh keuntungan. Usaha memenuhi kebutuhan dan usaha untuk memperoleh keuntungan ini dapat membuat manusia menjadi lupa diri dan tidak memperhatikan aturan, apalagi jika pelakunya adalah orang yang tidak berilmu dan memiliki nafsu yang tidak baik.Tulisan ini memuat secara komprehensif konsep jual beli mabrûr yang memperhatikan setiap sisi kebaikan dalam setiap dimensi sebuah transaksi jual beli. Transaksi jual beli dengan niat dan tujuan yang baik, produk barang dan jasa baik, proses, hasil serta dampak yang baik secara menyeluruh. Hal ini untuk menghilangkan kebiasaan buruk di masyarakat yang mengutamakan mencari keuntungan dengan mengabaikan aspek hukum dan etika dalam transaksi jual beli.
Results of bench tests of hydraulic dynamometer of type CFT-9.0 manufactured by Fuchino Co Ltd
Authors: Mikhailov V. E. , Kolpakov S. P. , Khomenok L. A. 
Published: November 2019

Topical issues of creating test benches for power drive units are considered. The results of testing a hydraulic dynamometer with the aim of clarifying its characteristics are presented. When creating test benches, it is important to choose the right power damping system with its accurate measurement. For these purposes hydraulic dynamometers (HD) are used. The domestic industry has not yet mass-produced them, experimental development is underway. In this regard, it seems appropriate to use imported diesel engines, for example, Japanese-made, of type CFT-9.0 manufactured by Fuchino Co Ltd. This equipment has a commercial preference over other foreign manufacturers. This article discusses the principle of HD operation, its design features, the identified shortcomings and ways to address them, the results of tests of the gas engine on a special bench of JSC «NPO CKTI».The tests carried out made it possible to verify the operability of the acquired HD, to determine the dependence of the HD power on the rotation frequency, the dependence of the cooling water flow rate on the HD power and the dependence of the HD power on the steam flow rate to the steam turbine drive.The results obtained indicate that the HD of type CFT-9.0 manufactured by «Fuchino Co Ltd» can be recommended as a hydrodynamic power absorber with its high-precision measurement in a wide range of rotation speed, modes and power consumption up to 8.5 MW.
Detection of Deterioration of Three-phase Induction Motor using Vibration Signals
Authors: Glowacz Adam , Glowacz Witold , Kozik Jarosław , Piech Krzysztof , Gutten Miroslav , Caesarendra Wahyu , Liu Hui , Brumercik Frantisek , Irfan Muhammad , Faizal Khan Z. 
Published: November 2019

Abstract
Nowadays detection of deterioration of electrical motors is an important topic of research. Vibration signals often carry diagnostic information of a motor. The authors proposed a setup for the analysis of vibration signals of three-phase induction motors. In this paper rotor fault diagnostic techniques of a three-phase induction motor (TPIM) were presented. The presented techniques used vibration signals and signal processing methods. The authors analyzed the recognition rate of vibration signal readings for 3 states of the TPIM: healthy TPIM, TPIM with 1 broken bar, and TPIM with 2 broken bars. In this paper the authors described a method of the feature extraction of vibration signals Method of Selection of Amplitudes of Frequencies – MSAF-12. Feature vectors were obtained using FFT, MSAF-12, and mean of vector sum. Three methods of classification were used: Nearest Neighbor (NN), Linear Discriminant Analysis (LDA), and Linear Support Vector Machine (LSVM). The obtained results of analyzed classifiers were in the range of 97.61 % – 100 %.
Characterization of Surface Micro-Roughness by Off-Specular Measurements of Polarized Optical Scattering
Authors: Liu Cheng-Yang , Chang Li-Jen 
Published: November 2019

Abstract
The characterization of surface micro-roughness is investigated by using off-specular measurements of polarized optical scattering. In the measurement system, the detection angles of optical scattering are defined by the vertical and level scattering angles. The rotating mechanism of angles is controlled by stepper motors. Waveplate and polarizer are used to adjust light polarization and detection. We conduct the optical scattering measurements by using four standard metal sheets of surface roughness. The nominal values (Ra) of standard micro-roughness are 1.6 μm, 0.8 μm, 0.4 μm, and 0.1 μm, respectively. Samples with different surface roughness are evaluated with the utilization of laser sources at three incident wavelengths. These polarized images are analyzed using a computer program to obtain the distribution of light intensity. The results show great correlation between the metal surface roughness and polarization states. This measurement system can be used to quickly and accurately distinguish between different surfaces and properties.