bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Turkish version of the ICIQ‐FLUTS, ICIQ‐FLUTS long‐form, ICIQ‐LUTS quality‐of‐life, and ICIQ‐FLUTS sexual functions
Authors: Gungor Uğurlucan Funda , Yasa Cenk , Yuksel Ozgor Bahar , Ayvacikli Goksen , Gunaydin Cansu , Balci Burcin K. , Yalcin Onay 
Published: February 2020

AbstractAimsTo enable the use of ICIQ‐FLUTS, ICIQ‐FLUTS‐long‐form (ICIQ‐FLUTS‐LF), ICIQ‐LUTS‐quality‐of‐life (ICIQ‐LUTSqol), and ICIQ‐FLUTS sexual functions (ICIQ‐FLUTSsex) in Turkish speaking women, questionnaires were translated into Turkish and validity, reliability, and sensitivity to change were evaluated in women suffering from urinary incontinence (UI).Materials and MethodsPermissions were obtained from ICIQ Advisory Board, English versions of the questionnaires were initially translated into Turkish, then back‐translated into English and translations were modified according to recommendations of ICIQ Advisory Board. Pilot testing was performed in 10 women. Validity (content/face validity and discriminant validity), reliability (test‐retest reliability and internal consistency), and sensitivity to change were evaluated.ResultsA total of 58 women with UI completed ICIQ‐FLUTS, ICIQ‐LUTSqol, and the ICIQ‐FLUTS‐LF, and 37 who were sexually active completed ICIQ‐FLUTSsex. All women completed same questionnaires 15 days later. More than 90% of women thought that the questions were clear, unequivocal, and comprehensive. Missing data were less than 1% indicating adequate content/face validity. Cronbach's α coefficients were .933 (ICIQ‐FLUTS), .979 (ICIQ‐LUTSqol), .865 (ICIQ‐FLUTS‐LF), and .863 (ICIQ‐FLUTSsex), representing adequate internal consistency. Kappa values and intraclass correlation coefficient for individual items were over 0.70, indicating adequate test‐retest reliability. A total of 52 healthy volunteers completed ICIQ‐FLUTS and ICIQ‐FLUTS‐LF, 30 completed ICIQ‐LUTSqol, and 30 sexually active healthy volunteers completed ICIQ‐FLUTSsex. All four questionnaires had good discriminant validity. Twenty‐eight women with UI were analyzed 3 months after treatment. There was significant improvement in four questionnaires in correlation with pre‐ and posttreatment bladder diary results showing good sensitivity to change.ConclusionTurkish versions of four ICIQ modules were shown valid and reliable and can be used in Turkish speaking women in the evaluation of UI.
Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability
Authors: Sheen Yi‐Shuan , Lin Ming‐Hsien , Tzeng Wen‐Chia , Chu Chia‐Yu 
Published: February 2020

AbstractEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) are used as a treatment for non‐small‐cell lung cancer. There have been some reports of EGFR‐TKIs being associated with vascular adverse events. We found that EGFR‐TKIs decreased the proliferation of HMEC‐1s (immortalized human dermal microvascular endothelial cells) and HMVECs (human dermal microvascular endothelial cells), and also inhibited the phosphorylation of EGFR and ERK. We examined the mRNA expression profile of erlotinib‐treated HMEC‐1s and identified IQ motif containing GTPase activating protein 1 (IQGAP1) as the most consistently up‐regulated transcript and protein. IQGAP1 was also overexpressed and co‐localized with endothelial cells in the lesional skin. Notably, increased IQGAP1 expression was associated with decreased transendothelial electrical resistance and increased vascular permeability in vitro. Erlotinib treatment enriched the staining of IQGAP1 and reduced the intensities of α‐catenin at the sites of cell–cell contact. In conclusion, erlotinib induces adherens junction dysfunction by modulating the expression of IQGAP1 in dermal endothelial cells. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A molecular electron density theory study of the Grignard reagent‐mediated regioselective direct synthesis of 1,5‐disubstituted‐1,2,3‐triazoles
Authors: Domingo Luis R. , Acharjee Nivedita 
Published: February 2020

AbstractThe [3 + 2] cycloaddition (32CA) reaction of phenyl azide4with ethynylbenzene5in presence of ethyl magnesium bromide (EtMgBr) has been studied within the Molecular Electron Density Theory with the aim to rationalise the high‐yielding direct regioselective synthesis of 1,5‐disubstituted‐1,2,3‐triazoles. Topological analysis of the electron localisation function (ELF) of phenyl azide4indicates that it has azwitterionicstructure participating inzw‐type32CA reactions. Computed activation parameters along the two feasible reaction paths for this 32CA reaction makes the rationalisation of the experimental outcomes possible. Grignard reagent‐mediated processes have a polar character and complete regioselectivity, which is in line with the fast, clean, and high yielding reaction experimentally observed. The reaction follows aone‐stepmechanism involving a high asynchronous transition state structure. Topological analysis of the ELF and calculated quantum theory of atoms‐in‐molecule parameters indicate that formation of new C–N single bonds does not begin exactly at the corresponding transition state structure.
Tomato spotted wilt orthotospovirus influences the reproduction of its insect vector, western flower thrips, Frankliniella occidentalis, to facilitate transmission
Authors: Wan Yanran , Hussain Sabir , Merchant Austin , Xu Baoyun , Xie Wen , Wang Shaoli , Zhang Youjun , Zhou Xuguo , Wu Qingjun 
Published: February 2020

AbstractBACKGROUNDTomato spotted wilt orthotospovirus (TSWV), one of the most devastating viruses of ornamental plants and vegetable crops worldwide, is transmitted by the western flower thrips, Frankliniella occidentalis (Pergande), in a persistent‐propagative manner. How TSWV influences the reproduction of its vector to enhance transmission and whether infection with TSWV changes the mating behavior of F. occidentalis are not fully understood.RESULTSTSWV‐exposed thrips had a significantly longer developmental time than non‐exposed individuals. More importantly, increased developmental time was predominantly associated with adults, a stage critical for dispersal and virus transmission. In addition, TSWV‐exposed F. occidentalis produced substantially more progeny than did non‐exposed thrips. Interestingly, most of the increase in progeny came from an increase in males, a sex with a greater dispersal and virus transmission capability. Specifically, the female/male ratio of progeny shifted from 1.3–7.0/1 to 0.6–1.1/1. As for mating behavior, copulation time was significantly longer in TSWV‐exposed thrips. Finally, females tended to re‐mate less when exposed to the virus. Resistance to re‐mating may lead to reduced sperm availability in females, which translates to a larger number of male progeny under a haplodiploid system.CONCLUSIONThese combined results suggest that TSWV can influence the developmental time, mating behavior, fecundity, and offspring sex allocation of its vector F. occidentalis to facilitate virus transmission. As such, a monitoring program capable of the earlier detection of the virus in host plants and/or its insect vector, thrips, using double‐antibody sandwich enzyme‐linked immunosorbent assay (DAS‐ELISA), real time quantitative polymerase chain reaction (RT‐qPCR) or virus detection strips might be beneficial for long‐term, sustainable management. © 2020 Society of Chemical Industry
Impact of sample preparation methods for characterizing the geochemistry of soils and sediments by portable X‐ray fluorescence
Authors: Goff Kathleen , Schaetzl Randall J. , Chakraborty Somsubhra , Weindorf David C. , Kasmerchak Chase , Bettis E. Arthur 
Published: February 2020

AbstractWe examined the impact of three different sample preparation methods on bulk soil geochemistry data obtained from a hand‐held, portable X‐ray fluorescence (pXRF) spectrometer. We generated data from a soil core recovered from the surface, downward into unaltered loess, and into a buried soil at a site in eastern Iowa. Samples were scanned (i) directly from field‐moist soil cores; (ii) after drying, grinding, and being loosely massed in plastic cups; and (iii) as pressed‐powder pellets. Data derived using these methods were compared with data obtained from a standard benchtop X‐ray fluorescence (XRF) unit. Generally, the results indicated that data from pressed powder pellets often provide the best correlation to benchtop XRF data, although the results were sometimes element or compound specific. Calcium oxide, Fe2O3, and K2O generally provided the strongest correlations between pXRF‐ and XRF‐reported values; SiO2data were more problematic. Field‐moist pXRF scans generally underestimated element concentrations, but the correlations between pXRF and benchtop XRF measurements were greatly improved after applying pXRF‐derived calibration standards. In summary, although element/compound data provided by pXRF showed significant relationships to benchtop XRF data, the results are improved with proper sample preparation (i.e., drying, grinding, pressing) and usually by calibrating the pXRF data against known standards.
Influence of crack on the steel plate shear walls strengthened by diagonal stiffeners
Authors: Khaloo Alireza , Foroutani Maryam , Ghamari Ali 
Published: February 2020

SummaryIn spite of existing comprehensive studies on the behavior of steel plate shear wall (SPSW), some aspects of the SPSW have remained unknown, yet. One of the important aspects that is unknown is the crack effect on the SPSW behavior in linear and nonlinear zones. Some experimental studies have been reported that SPSWs were fractured due to crack propagation. Therefore, the crack effect on the behavior of SPSW should be accounted in considering of SPSW behavior. Although the effect of crack on the thin SPSW has been investigated to a limited extent numerically, stiffened SPSPW, especially diagonally stiffened SPSW, has not been studied. In doing so, in this paper, the effect of crack effect on the behavior of diagonally stiffened SPSWs is studied parametrically and numerically. Numerical results showed that stiffened walls exhibit better behavior in the presence of crack compared with SPSW in both elastic and inelastic zones. Because crack propagates in nonlinear zone, it has not effective on elastic behavior of diagonally stiffened SPSW. The effect of crack was also presented as mathematical equations to estimate load–displacement curve that are in agreement with the finite element results especially for wall thinker stiffeners.
Dark matter bound state formation via emission of a charged scalar
Authors: Oncala Ruben , Petraki Kalliopi 
Published: February 2020

Abstract
The formation of stable or meta-stable bound states can dramatically affect the phenomenology of dark matter (DM). Although the capture into bound states via emission of a vector is known to be significant, the capture via scalar emission suffers from cancellations that render it important only within narrow parameter space. While this is true for neutral scalar mediators, here we show that bound-state formation via emission of a charged scalar can be extremely significant. To this end, we consider DM charged under a dark U(1) force and coupled also to a light complex scalar that is charged under the same gauge symmetry. We compute the cross-sections for bound-state formation via emission of the charged scalar, and show that they can exceed those for capture via vector emission, as well as annihilation, by orders of magnitude. This holds even for very small values of the DM coupling to the charged scalar, and remains true in the limit of global symmetry. We then compute the DM thermal freeze-out, and find that the capture into meta-stable bound states via emission of a charged scalar can cause a late period of significant DM depletion. Our results include analytical expressions in the Coulomb limit, and are readily generalisable to non-Abelian interactions. We expect them to have implications for Higgs-portal scenarios of multi-TeV WIMP DM, as well as scenarios that feature dark Higgses or (darkly-)charged inert scalars, including models of self-interacting DM.
Geology, alteration and lithogeochemistry of the Paleoproterozoic Korpela VMS occurrence in Eastern Finland
Authors: Hokka Janne 
Published: February 2020

AbstractKorpela is a Cu-Zn-Au VMS occurrence hosted by bimodal, sub-alkaline, volcanic and volcaniclastic rocks. It is part of a Svecofennian supracrustal sequence 1.93–1.91 Ga in age. In this study, lithogeochemical evidence is used to assess the VMS-prospectivity in the Korpela area to serve regional-scale exploration and provide detailed information on chemostratigraphy and hydrothermal alteration within the Korpela succession. Korpela is understood to have been formed in an evolved arc rift, possibly in a continental back-arc environment. The felsic rocks of the sequence are FII-FIIIa, HFSE-enriched (A-type) rhyolites overlain and, locally cross-cut, by mafic rocks with MORB/BABB signatures and felsic synvolcanic porphyry dykes. In the vicinity of Korpela, tonalitic subvolcanic intrusions intrude the supracrustal rocks which share textures common with local shallow VMS-related intrusion complexes. The Korpela area comprises a volcanic succession where primary volcanic textures are completely destroyed by multiple deformation, metamorphism and alteration. Using detailed volcanic chemostratigraphy established from downhole geochemical profiles, 12 chemostratigraphic units and 21 chemical rock types could be identified ranging from basalt to rhyolite. Several metamorphic mineral assemblages were identified which were further classified into six alteration types, i.e. Mg-Fe-S, K-Al-Fe-(± S), K-Al-Mg-Fe-S, K, Si-K-Ca-(± S) and Ca-(± Na), using a combination of mineralogy and geochemistry. The chemostratigraphy and alteration studies help in understanding the volcanic stratigraphy and in recognising a potential VMS-related alteration.
Endovascular aneurysm closure during out of office hours is not related to complications or outcome
Authors: van Lieshout Jasper H. , Verbaan Dagmar , Fischer Igor , Mijderwijk Hendrik-Jan , van den Berg René , Vandertop W. Peter , Klijn Catharina J.M. , Steiger Hans J. , de Vries Joost , Bartels Ronald H.M.A. , Beseoglu Kerim , Boogaarts Hieronymus D. 
Published: February 2020

Abstract
Purpose
A possible disadvantage of endovascular occlusion outside work hours is that complex procedures might expose patients to additional risk when performed in a suboptimal setting. In this prospective cohort study, we evaluated whether treatment during out of office hours is a risk factor for per-procedural complications and clinical outcome.

Methods
We included 471 endovascular-treated, consecutive aneurysmal subarachnoid hemorrhage patients (56.6 ± 13.1, 69% female), from two prospective observational databases which were retrospectively analyzed. Primary outcome was the occurrence of per-procedural complications. Secondary outcomes were good clinical outcome (modified ranking scale ≤ 2) and death at 6-month follow-up. We determined odds ratios (OR) with 95% confidence intervals (CI) by ordered polytomous logistic regression analysis and adjusted odds ratios (aOR) for age, World Federation of Neurosurgical Societies grade, and time to treatment.

Results
Most patients were treated during office hours (363/471; 77.1%). Treatment during out of office hours did not result in an increased risk of per-procedural complications (OR 0.85 (95% CI 0.53–1.37; p = 0.51). Patients treated during out of office hours displayed similar odds of good clinical outcome and death after 6 months (OR 1.14, 95% CI 0.68–1.97 and 1.16 95% CI 0.56–2.29, respectively) compared to patients treated during office hours.

Conclusion
In our study, endovascular coil embolization during out of office hours did not expose patients to an increased risk of procedural complications or affect functional outcome after 6 months.
Preoperative 18F-FDG PET/CT tumor markers outperform MRI-based markers for the prediction of lymph node metastases in primary endometrial cancer
Authors: Fasmer Kristine E. , Gulati Ankush , Dybvik Julie A. , Ytre-Hauge Sigmund , Salvesen Øyvind , Trovik Jone , Krakstad Camilla , Haldorsen Ingfrid S. 
Published: February 2020

Abstract
Objectives
To compare the diagnostic accuracy of preoperative 18F-FDG PET/CT and MRI tumor markers for prediction of lymph node metastases (LNM) and aggressive disease in endometrial cancer (EC).

Methods
Preoperative whole-body 18F-FDG PET/CT and pelvic MRI were performed in 215 consecutive patients with histologically confirmed EC. PET/CT-based tumor standardized uptake value (SUVmax and SUVmean), metabolic tumor volume (MTV), and PET-positive lymph nodes (LNs) (SUVmax > 2.5) were analyzed together with the MRI-based tumor volume (VMRI), mean apparent diffusion coefficient (ADCmean), and MRI-positive LN (maximum short-axis diameter ≥ 10 mm). Imaging parameters were explored in relation to surgicopathological stage and tumor grade. Receiver operating characteristic (ROC) curves were generated yielding optimal cutoff values for imaging parameters, and regression analyses were used to assess their diagnostic performance for prediction of LNM and progression-free survival.

Results
For prediction of LNM, MTV yielded the largest area under the ROC curve (AUC) (AUC = 0.80), whereas VMRI had lower AUC (AUC = 0.72) (p = 0.03). Furthermore, MTV > 27 ml yielded significantly higher specificity (74%, p < 0.001) and accuracy (75%, p < 0.001) and also higher odds ratio (12.2) for predicting LNM, compared with VMRI > 10 ml (58%, 62%, and 9.7, respectively). MTV > 27 ml also tended to yield higher sensitivity than PET-positive LN (81% vs 50%, p = 0.13). Both VMRI > 10 ml and MTV > 27 ml were significantly associated with reduced progression-free survival.

Conclusions
Tumor markers from 18F-FDG PET/CT outperform MRI markers for the prediction of LNM. MTV > 27 ml yields a high diagnostic performance for predicting aggressive disease and represents a promising supplement to conventional PET/CT reading in EC.

Key Points
• Metabolic tumor volume (MTV) outperforms other 18F-FDG PET/CT and MRI markers for preoperative prediction of lymph node metastases (LNM) in endometrial cancer patients.
• Using cutoff values for tumor volume for prediction of LNM, MTV > 27 ml yielded higher specificity and accuracy than VMRI> 10 ml.
• MTV represents a promising supplement to conventional PET/CT reading for predicting aggressive disease in EC.
Repeated implementation with overlapping generations of agents
Authors: Āzacis Helmuts 
Published: February 2020

AbstractWe study repeated implementation in a model with overlapping generations of agents. A social choice function selects an alternative in each period as a function of preferences of those agents who are alive in that period. When the agents’ preferences do not change during their lifetime, we show that any social choice function satisfying a mild unanimity condition is repeatedly implementable in subgame perfect equilibrium if there are at least three agents and they live sufficiently long. When the agents’ preferences change every period, we show that only efficient social choice functions can be repeatedly implementable if the agents live sufficiently long.
Ki67 as a prognostic factor of craniopharyngioma’s recurrence in paediatric population
Authors: Moszczyńska Elżbieta , Prokop-Piotrkowska Monika , Bogusz-Wójcik Agnieszka , Grajkowska Wiesława , Szymańska Sylwia , Szalecki Mieczysław 
Published: February 2020

AbstractPurposeCraniopharyngioma is one of the most frequent benign tumours of the central nervous system in the paediatric population. Although it is a benign tumour according to the WHO classification, it significantly deteriorates the patient’s quality of life. The aim of this study is to assess if proliferation index Ki67 can be a useful marker of the risk of craniopharyngioma’s recurrence.MethodsExpression of Ki67 was examined in 85 specimens of primary craniopharyngioma and in 11 specimens of the recurring tumour. In all the cases, adamantinomatous type of craniopharyngioma was diagnosed. Values of Ki67 expression were compared between patients with and without recurrence, between patients with progression and relapse and between primary and recurrent tumours.ResultsNo statistically significant differences were found between proliferation index Ki67 values in tumours with recurrence and without (median values 2.5% and 3%, respectively,p = 0.69). The median value of proliferation index Ki67 in progression group was 1% and in the relapse group 4%; no statistical significance between those groups was found (p = 0.067). The median value of proliferation index Ki67 in primary tumours was 3% (0–20%) and in recurrent tumours it was 5% (0–14%). Despite the lack of statistical significance (p = 0.61), a tendency towards higher values of Ki67 in recurring tumours in comparison with primary tumours was shown.ConclusionsProliferation index Ki67 is not a reliable prognostic factor of craniopharyngioma’s recurrence.
Efficacy of screening using annual fecal immunochemical test alone versus combined with one-time colonoscopy in reducing colorectal cancer mortality: the Akita Japan population-based colonoscopy screening trial (Akita pop-colon trial)
Authors: Saito Hiroshi , Kudo Shin-ei , Takahashi Noriaki , Yamamoto Seiichiro , Kodama Kenta , Nagata Koichi , Mizota Yuri , Ishida Fumio , Ohashi Yasuo 
Published: February 2020

Abstract
Purpose
Screening programs using fecal occult blood testing help reduce mortality from colorectal cancer (CRC). Colonoscopy and colonoscopy combined with fecal occult blood testing are considered alternatives with higher sensitivity than fecal tests; however, to our knowledge, randomized controlled trials (RCTs) providing such evidence have not been reported. Therefore, this study aimed to compare screening using the fecal immunochemical test (FIT) combined with colonoscopy and FIT alone to evaluate the efficacy of colonoscopy screening in reducing CRC mortality.

Methods
This multicenter, prospective, randomized, controlled study included average-risk individuals for CRC living in the study areas and aged 40–74 years. The exclusion criteria were history of CRC, hereditary non-polyposis CRC, familial adenomatous polyposis, inflammatory bowel diseases, history of cancer other than CRC within the past 5 years, and not expected to survive from comorbid illness. The intervention group underwent one-time colonoscopy and annual FIT, while the control group underwent annual FIT. The primary endpoint was mortality from CRC, while the secondary endpoints were cumulative incidence of invasive CRC, advanced CRC (invasion into the muscle layer or deeper), invasive cancer and screening sensitivities and specificities of invasive CRC, whole CRC, advanced neoplasia, and prevalence of adverse events. The intervention and control groups comprised 4876 and 4875 participants, respectively.

Conclusion
This explanatory RCT evaluated the efficacy of colonoscopy screening by valid statistical inference based on randomization. Data on adverse events from this kind of screening are necessary when considering implementation of future screening programs.

Trial registration
UMIN Clinical Trials Registry, number UMIN000001980.