bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple change in logistic procedure improves response rate to QOL assessment: a report from the Japan Children’s Cancer Group
Authors: Sato Iori , Soejima Takafumi , Ishida Yasushi , Maeda Miho , Koh Katsuyoshi , Kamibeppu Kiyoko 
Published: June 2020

Abstract
Background
Reducing non-completion of quality-of-life assessment in clinical trials is an important challenge in obtaining accurate data and unbiased interpretation of patients’ quality-of-life for each regimen. We evaluated the effect of changing our questionnaire distribution procedure in a multicenter phase II/III trial on the response rate to a quality-of-life questionnaire.

Methods
In the trial, we distributed 1767 questionnaires and 1045 were returned. We adopted a regression discontinuing design and estimated the change in response rate between pre-intervention (quality-of-life questionnaires were sent to each center soon after patient registration) and post-intervention (a set of tailored questionnaires was sent just before the first quality-of-life assessment).

Results
The post-intervention response rate was higher (odds ratio = 1.62) than the pre-intervention response rate.

Conclusions
A simple logistic intervention reduced the non-completion of QOL assessment in this case, suggesting that a simple change can contribute to improving clinical trial accomplishment.
Effects of storage periods and positioning during storage on hatchability and weight of the hatched chicks from different egg sizes
Authors: Ayeni Akinlolu Oluwafemi , Agbede Johnson Oluwasola , Igbasan Francis Adegbaye , Onibi Gbenga Emmanuel , Adegbenro Muyiwa 
Published: June 2020

Abstract
Background
This study evaluates the effects of storage periods (1, 4, 7, 10, and 13 days), egg size (small 60–64 g, medium 65–69 g, and large ≥ 70 g), and egg positioning with air cell facing either down or up during storage on hatchability percentages and day-old chick’s weight. One thousand and five hundred (1500) fertile eggs from Arbor acre broiler breed were purchased and arranged each according to egg sizes into five (5) different storage periods of 100 eggs per storage period. Each storage period was subdivided into 2 groups of 50 eggs each based on positioning during storage. A completely randomized design in 3 × 5 × 2 factorial arrangement was adopted. Stored eggs were incubated for hatch with recording of weights of the hatched chicks, and the hatchability rate was calculated.

Results
The results indicated eggs stored for a day and 4 days had maximum hatchability, but declined slightly as the storage period increased (92 to 78%). The eggs positioned down generally had better hatchability. However, medium-sized eggs had the highest hatchability percentage. On the other hand, large-sized eggs stored for longer period attained higher chick weight compared to medium- and small-sized eggs, but large-sized eggs positioned down gave a better chick weight. Generally, eggs stored with air cell down present superior chick weight.

Conclusion
Storage period and egg positioning during storage affect the subsequent egg hatchability and weight of the hatched chicks from different egg sizes. However, egg storage must not exceed 4 days for optimum hatchability and weight of the hatched chicks. In addition, storing of eggs with air cell down might also enhance the hatchability and weight of hatched chicks irrespective of the weight of the eggs.
The musculoskeletal impairment negatively impacts the quality of life of children and adolescents with psoriasis
Authors: Meneghetti Thaís Cugler , Padilha Thaís Mayumi Honda , Azevedo Valderílio Feijó , Cat Mônica Nunes Lima , Sarolli Bruna Maria Stofela , de Carvalho Vânia Oliveira 
Published: June 2020

AbstractBackgroundThe severity of nail disease, the presence of arthralgia and fatigue are predictors of development of psoriatic arthritis (PsA) in patients with psoriasis (Pso). In children, little is known about the musculoskeletal (MSK) impairment in patients with Pso and its effect on health-related quality of life (HRQoL).ObjectivesTo determine the frequencies of pain and MSK inflammation (i.e., arthritis, enthesitis, and sacroiliitis) among children and adolescents with Pso and its relationship to HRQoL and fatigue.MethodsPediatric patients with Pso underwent a rheumatologic physical examination to evaluate synovitis, enthesalgia, sacroiliac joint (SIJ) pain and tender points of fibromyalgia. The core set of domains recommended by the GRAPPA - OMERACT to be measured in PsA studies was assessed. Ultrasound (US) was performed in clinical cases of enthesitis, and magnetic resonance imaging (MRI) was performed in cases of SIJ pain.ResultsForty-three participants (10 ± 2.9 years old) were evaluated. Pain on palpation of the entheses was observed in 10 (23.2%) patients and pain on SIJ palpation was observed in 3 (7%). No patient presented with synovitis; one presented with enthesitis on US, but MRI did not confirm sacroiliitis in any case. Patients with MSK pain had greater skin disease severity (PASI 5.4 vs. 2,p <  0.01), worse fatigue, and lower HRQoL scores on all instruments used. The estimated risk of HRQoL impairment was eight times higher in the presence of MSK pain, which was an independent predictive factor. With a NAPSI greater than 30, the probability of pain was greater than 80%.ConclusionMSK pain is frequent among children with Pso, related to the severity of skin and nail disease, and negatively affects HRQoL. The typically used complementary exams might not detect the inflammatory process caused by Pso.
Engaging stakeholders in the adaptation of the Connect for Health pediatric weight management program for national implementation
Authors: Simione Meg , Frost Holly M. , Cournoyer Rachel , Mini Fernanda Neri , Cassidy Jackie , Craddock Cassie , Moreland Jennifer , Wallace Jessica , Metlay Joshua , Kistin Caroline J. , Sease Kerry , Hambidge Simon J. , Taveras Elsie M. 
Published: June 2020

Abstract
Background
Connect for Health is an evidence-based weight management program with clinical- and family-facing components for delivery in pediatric primary care for families of children ages 2 to 12 years. We used the Consolidated Framework for Implementation Research (CFIR) to guide formative work prior to national implementation. The purpose of this study was to describe the process and results of stakeholder engagement and program adaptation.

Methods
We used mixed qualitative and quantitative methods to iteratively adapt and optimize the program by assessing needs and perspectives of clinicians and parents, as well as contextual barriers, facilitators, and organizational readiness for the uptake of the proposed program tools and implementation strategies. We conducted interviews with primary care clinicians from four health care organizations in Boston, MA; Denver, CO; and Greenville, SC, and used principles of immersion-crystallization for qualitative analyses. We also conducted surveys of parents of children with a body mass index ≥ 85th percentile.

Results
We reached thematic saturation after 52 clinician interviews. Emergent themes representing the CFIR domains of intervention characteristics, outer and inner setting, and process included (1) importance of evidence-based clinical decision support tools that integrate into the workflow and do not extend visit time, (2) developing resources that respond to family’s needs, (3) using multimodal delivery options for family resources, (4) addressing childhood obesity while balancing competing demands, (5) emphasizing patient care rather than documentation and establishing sustainability plans, and (6) offering multiple training methods that incorporate performance feedback. Of the parents surveyed (n = 400), approximately 50% were Spanish-speaking and over 75% reported an annual income < $50,000. Parents affirmed the importance of addressing weight management during well-child visits, being provided with referrals and resources, and offering multiple methods for resource delivery. Decisions about program modifications were made at the program and healthcare-system level and based on stakeholder engagement findings. Modifications included cultural, geographic, and target audience adaptations, as well as varied resource delivery options.

Conclusions
To ensure the fit between the Connect for Health program and national implementation settings, adaptations were systematically made through engagement of clinician and parent stakeholders to support adoption, sustainability, and health outcomes.

Trial registration
NCT04042493
Role of circulating miRNA-17-3P as a potential diagnostic biomarker for sporadic colon cancer in Egyptian cohort
Authors: Aziz Mohamed Ahmed Abdel , Ahmed Ezzat Ali , Elbanna Amany Ahmed , Halim Reham Abdel , Afifi Khloud Salahuddin , Nouh Hanan Hosny 
Published: June 2020

Abstract
Background
Cancer colon is one of the leading causes of death and MiRNAs are incorporated in biological pathways that affect tumorigenesis as proved by multiple studies. The present study aimed to investigate whether miR-17-3p is elevated in the plasma free samples of colon cancer patients in correlation with other tumor markers (CEA, CA19.9).

Results
MiRNA 17-3P plasma free sample levels were significantly elevated in the plasma free samples of colon cancer patients compared with healthy controls (P < 0.001); on the other hand, serum levels of CA19.9 were significantly higher in colon cancer patients compared to healthy controls while serum levels of CEA were found to be of no statistical significance.

Conclusion
The detection miRNA-17-3p may be considered of clinical value for the detection of colon cancer; also, CA19.9 detection was found to significantly increase the sensitivity and specificity of a colon cancer diagnosis.
Urachal abscess in a child with single kidney and multiple anomalous vertebrae—a case report and literature review
Authors: Abou Chaar Mohamad K. , Al-Shamaileh Tamador , Saleem Mohammad M. 
Published: June 2020

Abstract
Background
Urachal anomalies (UAs) are rare in children; the most encountered are urachal cysts, urachal sinus, and urachal diverticulum. Other associated anomalies have been reported to include renal and abdominal wall defects. No skeletal anomalies have been reported to date.

Case presentation
We present a case of a 20-month-old female patient, who presented to our emergency department with a fever of 2 weeks duration associated with colicky abdominal pain, a tender abdomen, and an infraumbilical mass. The suspicion of urachal sinus abscess was confirmed by ultrasound. The patient was also found to have a single left kidney and multiple vertebral segmental anomalies on a full-body computed tomography scan. The patient underwent open surgical excision of the urachal abscess without complications on follow-up.

Conclusion
Urachal abscess is rare in children. Associated anomalies include renal and abdominal wall defects. To our knowledge and based on our meticulous search through the literature, this is the first case to report a combination of renal and skeletal findings in a child. Whenever a urachal remnant is found in a patient, a radiological investigation should be made to rule out associated anomalies.
The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility
Authors: Dhillon-Smith Rima K , Tobias Aurelio , Smith Paul P , Middleton Lee J , Sunner Kirandeep K , Baker Krystyna , Farrell-Carver Samantha , Bender-Atik Ruth , Agrawal Rina , Bhatia Kalsang , Chu Justin J , Edi-Osagie Edmond , Ewies Ayman , Ghobara Tarek , Gupta Pratima , Jurkovic Davor , Khalaf Yacoub , Mulbagal Khashia , Nunes Natalie , Overton Caroline , Quenby Siobhan , Rai Raj , Raine-Fenning Nick , Robinson Lynne , Ross Jackie , Sizer Andrew , Small Rachel , Underwood Martyn , Kilby Mark D , Daniels Jane , Thangaratinam Shakila , Chan Shiao , Boelaert Kristien , Coomarasamy Arri 
Published: June 2020

Abstract

Objective
To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.

Design
Observational cohort study.

Setting
A total of 49 hospitals across the United Kingdom between 2011 and 2016.

Participants
Women aged 16 to 41years with history of miscarriage or subfertility trying for a pregnancy.

Methods
Prevalences and 95% confidence intervals (CIs) were estimated using the binomial exact method. Multivariate logistic regression analyses were conducted to identify risk factors for thyroid disease.

Intervention
None.

Main Outcome Measure
Rates of thyroid dysfunction.

Results
Thyroid function and thyroid peroxidase antibody (TPOAb) data were available for 19213 and 19237 women, respectively. The prevalence of abnormal thyroid function was 4.8% (95% CI, 4.5-5.1); euthyroidism was defined as levels of thyroid-stimulating hormone (TSH) of 0.44 to 4.50 mIU/L and free thyroxine (fT4) of 10 to 21 pmol/L. Overt hypothyroidism (TSH &gt; 4.50 mIU/L, fT4 &lt; 10 pmol/L) was present in 0.2% of women (95% CI, 0.1-0.3) and overt hyperthyroidism (TSH &lt; 0.44 mIU/L, fT4 &gt; 21 pmol/L) was present in 0.3% (95% CI, 0.2-0.3). The prevalence of subclinical hypothyroidism (SCH) using an upper TSH concentration of 4.50 mIU/L was 2.4% (95% CI, 2.1-2.6). Lowering the upper TSH to 2.50 mIU/L resulted in higher rates of SCH, 19.9% (95% CI, 19.3-20.5). Multiple regression analyses showed increased odds of SCH (TSH &gt; 4.50 mIU/L) with body mass index (BMI) ≥ 35.0 kg/m2 (adjusted odds ratio [aOR] 1.71; 95% CI, 1.13-2.57; P = 0.01) and Asian ethnicity (aOR 1.76; 95% CI, 1.31-2.37; P &lt; 0.001), and increased odds of SCH (TSH ≥ 2.50 mIU/L) with subfertility (aOR 1.16; 95% CI, 1.04-1.29; P = 0.008). TPOAb positivity was prevalent in 9.5% of women (95% CI, 9.1-9.9).

Conclusions
The prevalence of undiagnosed overt thyroid disease is low. SCH and TPOAb are common, particularly in women with higher BMI or of Asian ethnicity. A TSH cutoff of 2.50 mIU/L to define SCH results in a significant proportion of women potentially requiring levothyroxine treatment.
Effects of Land versus Water Walking Interventions on Vascular Function in Older Adults
Authors: HAYNES ANDREW , NAYLOR LOUISE H. , SPENCE ANGELA L. , ROBEY ELISA , COX KAY L. , MASLEN BARBARA A. , LAUTENSCHLAGER NICOLA T. , CARTER HOWARD H. , AINSLIE PHILIP N. , GREEN DANIEL J. 
Published: June 2020

ABSTRACT

Purpose
Endothelial dysfunction is an early and integral atherogenic event. Interventions that improve endothelial function also reduce cardiovascular risk. Due largely to the direct hemodynamic effects of repetitive exercise on the artery wall, exercise training has shown to enhance endothelial function. Land walking (LW) and water walking (WW) induce distinct hemodynamic responses, so the comparison of their effects provides an approach to study shear stress effects on endothelial function. We hypothesized that LW and WW training would have different effects on peripheral artery endothelial function.

Methods
Fifty-one sedentary, older (age = 61.9 ± 6.6 yr, 23.5% male) individuals were randomized into one of three groups: control (n = 16), or one of two exercise groups consisting of 3 × 50 min supervised and individually tailored walking sessions per week for 24 consecutive weeks, performed either on LW (n = 17) or on WW (n = 18). Brachial artery endothelial function (flow-mediated dilation) and smooth muscle cell function (glyceryl trinitrate administration) were tested in all participants before (week 0) and after (week 24) the intervention.

Results
Differences were apparent in flow-mediated dilation change between the LW group (week 0, 5.39% ± 0.71%, to week 24, 7.77% ± 0.78%; P = 0.009) and the control group (week 0, 5.87% ± 0.73%, to week 24, 5.78% ± 0.78%). No differences in artery dilation response were found after glyceryl trinitrate administration (all P > 0.05).

Conclusion
This study suggests that 6-month center-based LW may be superior to WW in terms of improvement in arterial endothelial function in older sedentary individuals.
Correlation of ultrasound placental diameter & thickness with gestational age
Authors: Njeze Ngozi R. , Ogbochukwu Joseph O. , Chinawa Josephat M. 
Published: June 2020

Background & Objectives: Estimation of fetal maturity is common in obstetric practice especially when the women do not keep accurate menstrual records. An accurate establishment of expected date of delivery is fundamental to the management of both high risk and normal pregnancies. The objective of this study was to determine the placental diameter (PD), placental thickness (PT) and to establish a correlation between PD, PT and gestational age.
Methods: This is an observational cross-sectional study that examines by means of ultrasonography the correlation between placental diameter and thickness with gestational age in Enugu, South East, Nigeria.
Results: A total of 400 healthy subjects were recruited in 3rd trimester of pregnancy having fulfilled the inclusion criteria. PD and PT in this study did not correlate with parity. There is a linear increase of gestational age and placental thickness and diameter. These increases heighten between 38th week gestation and 40 weeks’ gestation. 205.0±1.4, 43.00±0.0 to 215.0±1.4, 46.00±2.8 respectively.
Conclusion: Placental thickness and Placental diameter can be used to predict gestational age. It is therefore advised to use PT & PD in ultrasound obstetric assessment especially when Last menstrual period (LMP) is not clear.
doi: https://doi.org/10.12669/pjms.36.5.1938
How to cite this:Njeze NR, Ogbochukwu JO, Chinawa JM. Correlation of ultrasound placental diameter & thickness with gestational age. Pak J Med Sci. 2020;36(5):1058-1062. doi: https://doi.org/10.12669/pjms.36.5.1938
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Gynandromorphy in Eulaema atleticana Nemésio (Apidae, Euglossini)
Authors: Silveira Maxwell Souza , Peixoto Maria Helena Pereira , Martins Celso Feitosa , Zanella Fernando César Vieira 
Published: June 2020

A gynandromorph specimen of Eulaema atleticana Nemésio, the first registered in Eulaema, is described. The E. atleticana gynandromorph was captured using an eucalyptol scent trap, in the Mata do Buraquinho Reserve, an Atlantic Forest fragment. The study site has 550 ha and is located in the urban area of the Municipality of João Pessoa, State of Paraíba, Northeast Brazil. The specimen presents antero-posterior and bilateral asymmetry. The head presents only male morphological characteristics. The mesosoma is composed by male and female structures, with male fore and middle legs. The right hind tibia shows a mosaic of male and female characters, with rudiments of the tibial organ and a corbicula. The metasoma presents only female characters.
Gynandromorfia em Eulaema atleticana Nemésio (Apidae, Euglossini)
Resumo. É descrito um espécime ginandromorfo de Eulaema atleticana Nemésio. O primeiro registrado em Eulaema. O espécime foi coletado em armadilha de cheiro, na reserva da Mata do Buraquinho, um fragmento de Mata Atlântica, localizado no perímetro urbano da cidade de João Pessoa, Paraíba, Nordeste, Brasil. O espécime apresenta assimetria bilateral e anteroposterior. A cabeça possui apenas caracteres de macho. O mesossoma é composto por caracteres de macho e fêmea, com as pernas anteriores e medianas apresentando caracteres de macho. Nas pernas posteriores, a tíbia direita apresenta um mosaico de caracteres masculinos e femininos com rudimentos do órgão tibial e da corbícula. Todas as características do metassoma são de fêmea.
Sinopse dos Phasmatodea (Insecta) Descritos para o Brasil
Authors: Araujo Fernanda Figueiredo de , Garraffoni André Rinaldo Senna 
Published: June 2020

A sistemática é a ciência que descreve, nomeia, classifica e determina as relações entre os seres vivos. Atualmente ela enfrenta alguns problemas como a falta de especialistas em alguns grupos e regiões pouco amostradas. Os fasmídeos ainda são pouco estudados no Brasil e não existe registro de especialistas na ordem, causando dessa forma, diversas dificuldades na identificação dos espécimes do táxon. Contudo, apesar desse baixo conhecimento é possível notar vários problemas taxonômicos e pouca literatura disponível. Com isso, este trabalho tem como objetivo reconhecer e listar as espécies de Phasmatodea originalmente descritos para o Brasil, além de tecer alguns comentários sobre o histórico taxonômico do grupo no país.
Synopsis of Phasmatodea (Insecta) Described from Brazil
Abstract. Systematics involves description, naming of taxa, classification and phylogenetics determination of evolutionary relationships among the living. The decline in taxonomists available and the lack of taxonomic expertise lead to the so-called taxonomical impediments. The diversity and distribution of the phasmids in Brazil is still little known as any taxonomist is available in the country. However, although this poor knowledge in the Brazilian phasmids, it is possible to observe many taxonomical problems, very few literatures available. Thus, in this paper we listed all species originally described from Brazil and pointed out some notes about the taxonomic history of the phasmids from Brazil.
Novas Plantas Hospedeiras para o Percevejo Fitófago Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae)
Authors: Pires Evaldo Martins , Ruffato Solenir , Manica Clovis Luiz Moraes , Soares Marcus Alvarenga , Lacerda Mabio Chrisley 
Published: June 2020

Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae) é um percevejo fitófago que pode ser encontrado em diversas culturas agrícolas devido à oferta de alimento e condições favoráveis ao seu desenvolvimento. O objetivo desta pesquisa foi registrar a ocorrência de L. zonatus em plantas de Malpighia emarginata Sessé & Moc (Malpighiaceae), Morus nigra Linnaeus (Moraceae), Mangifera indica Linnaeus (Anacardiaceae) no município de Sinop, Mato Grosso, Brasil. Recomenda-se a inclusão de L. zonatus em monitoramentos visando o Manejo Integrado de Pragas (MIP) nestas plantas.
New Host Plants for Phytophagous Bug Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae)
Abstract. Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae) is a phytophagous bug that can be found in several crops due to availability of food and favorable conditions for the development. The aim of this research was to record the occurrence of L. zonatus colonizing plants of Malpighia emarginata Sessé & Moc (Malpighiaceae), Morus nigra Linnaeus (Moraceae), Mangifera indica Linnaeus (Anacardiaceae) in Municipality of Sinop, Mato Grosso, Brazil. L. zonatus should be included in monitoring for the Integrated Pest Management (IPM) in these plants.
Interfirm Exchange and Innovation in Platform Ecosystems: Evidence from Apple’s Worldwide Developers Conference
Authors: Foerderer Jens 
Published: June 2020

Platform firms’ success depends on complementary innovation. This paper studies the relation between opportunities for interfirm exchange and complementary innovation. An empirical study of a sample of app developer firms attending Apple’s 2016 Worldwide Developers Conference suggests three findings. First, the opportunity to exchange stimulated innovation in the form of major app updates that received positive consumer feedback. Second, the effects were more pronounced for older and larger firms, potentially because these firms have more experience and resources to leverage exchanges and safeguard against knowledge spillovers. Third, part of the effects may be attributed to learning and collaborations.This paper was accepted by Anandhi Bharadwaj, information systems.