bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KEBERLANJUTAN ADOPSI KAPAS TRANSGENIK DI SULAWESI SELATAN
Authors: Wahyudi Agus , Taher Syahrial , Watt Rahmi 
Published: July 2020

<p>Adopsi Kapas transgenik yang diinlroduksi secara terbatas sejak tahun 2000 di tujuh kabupaten di Sulawesi Selatan perlu dicvaluasi kebcrlanjutannya Penelitian ini bertujuan untuk menganalisis faktor - faktor yang mempengaruhi peluang keberlanjutan petani dalam mengadopsi kapas transgenik di daerah introduksi yaitu tujuh kabupaten di Provinsi Sulawesi Selatan. Kerangka penelitian yang digunakan adalah peluang keberlanjutan adopsi dipengaruhi oleh karaktcr subyek, karaktcr inovasi, dan lingkungan fisik dan sosial. Dengan kriteria sebaran dan luas kapas transgenik, pola sebaran curah hujan, dan waktu panen maka daerah yang terpilih adalah Kabupaten Bantaeng, Takalar, Gowa, dan Bulukumba, dan penelitian dilaksanakan pada bulan Agustus-September 2002. Metode pengambilan contoh petani digunakan metode acak sederhana, karena homogenitas Icarakter yang diinginkan relatif tinggi. Metode analisis data yang digunakan adalah analisis regresi berganda yang pendugaannya dengan metode maximum likelihood. Hasil analisis menunjukkan bahwa lebih dai 50% petani berpeluang untuk bcrhenti mengadopsi. Hal ini antara lain disebabkan ketidakmampuan petani untuk menanggung resiko usahatani kapas transgenik yang tinggi, sedang pendapatan yang diharapkan kurang stabil. Selain itu adopsi berpeluang besar akan berlanjut di daerah yang iklimnya sesuai dan kompatible dengan musim dan pola tanam yang ada.</p><p>Kata kunci: Kapas transgenic, adopsi, keberlanjutan, resiko usahatani, pendapatan</p><p> </p><p><strong>ABSTRACT</strong></p><p><strong>Analysis of sustainability of transgenic cotton adoption in South Sulawesi</strong></p><p>The adoption of transgenic conon that has been introduced since 2000 in seven regencies of South Sulawesi need to be evaluated further. The objective of the study was to analyze factors which influenced the adoption of transgenic cotton by the farmers in the introduction area. The research frame used is sustainability of adoption depend on characteistics of subjects and innovation and physical and social environment. Citeia used to determine research area were distribution and coverage of transgenic conon farms, distibution pattern of rainfall, and time of harvest. The area chosen were Regency of Bantaeng, Takalar, Gowa, and Bulukumba. The sampling method used was simple random sampling, since the population was relatively homogen. The results of the analysis indicated that more than SO % of the farmers had a chance to stop adopting the transgenic conon. Il happened because the farmers were uncapablc to take the isk of transgenic coton farming which was very high, while the income rom this farming was not stable. However, the adoption of transgenic cotton is potential in the area where the climate is suitable and compatible with the seasons and existing farming system.</p><p>Key words: Transgenic coton, adoption, sustainability, farm risk, income</p>
A DINÂMICA FLUVIAL DO RIO ACRE: UMA ANÁLISE AMBIENTAL DO TRECHO URBANO DA CIDADE DE RIO BRANCO-AC
Authors: Bonfanti Dhuliani Cristina , Lima Frank Thieny Brito de , Ferreira Luiz Carlos Aragão , Santos Waldemir Lima dos 
Published: July 2020

Estudos que abordam a dinâmica fluvial em bacias hidrográficas são considerados de extrema importância por discutir seu funcionamento natural ou alterado por ações antrópicas. O objetivo desse estudo foi analisar a dinâmica Geofluvial da área urbana do rio Acre. Para alcançar este propósito, o estudo foi baseado nas técnicas de Christoffoletti (1980) e da pesquisa de campo que ocorreu no mês de dezembro de 2017. Através destas medidas foi possível observar os aspectos físicos, ambientais e sociais que estão ocorrendo as margens do rio Acre. Neste sentido, foi possível compreender que o rio Acre é um rio capaz e competente, que tem os seus processos alterados pela presença da urbanização em suas margens.
BRASIGUAIOS E SUA INFLUÊNCIA POLÍTICA E ECONÔMICA NO PARAGUAI: RACISMO E NACIONALISMO NO MERCOSUL DO SÉCULO XXI
Authors: Carneiro Filho Camilo Pereira , Santos Jéssica Alves dos , Vanderlei Maria Luiza Nogueira 
Published: July 2020

A população de cidadãos de origem brasileira no Paraguai, denominada de brasiguaios, possui uma identidade cultural diferente da paraguaia. Esta comunidade, que passou a ser cada vez mais numerosa naquele país a partir da década de 1970 era estimada, em 2015, em 332.042 indivíduos. Contingente formado a partir do projeto de Marcha al Este do presidente Alfredo Stroessner, que abriu terras até então cobertas pela Mata Atlântica localizada na fronteira do Paraguai com o Brasil para colonos brasileiros (a maioria de origem europeia, proveniente da região Sul do Brasil) que passariam a desenvolver a sojicultura e aplicar práticas oriundas da Revolução Verde. Passadas mais de quatro décadas, o contingente brasileiro no Paraguai impõe sua cultura, seu idioma e alguns de seus membros possuem grande influência política e econômica no país. A presença do contingente brasileiro resulta em momentos de tensão no quotidiano político e social paraguaio, sendo que o recente golpe de Estado sofrido pelo presidente Lugo em 2012 teve participação de membros da comunidade brasiguaia. Face ao exposto o presente trabalho tem o objetivo de aferir os impactos da presença brasiguaia no Paraguai e analisar se esta configura um risco à democracia neste país. Trata-se de uma pesquisa qualitativa, sob a ótica das Relações Internacionais, pautada em análise bibliográfica e enriquecida por cartografia produzida pelos autores.
Socio-demographic and clinical characteristics of diabetes mellitus in rural Rwanda: Time to contextualize the interventions? A cross-sectional study
Authors: Munganyinka Charlotte Bavuma , Musafiri Sanctus , Rutayisire Pierre-Claver , Ng’ang’a Loise M , McQuillan Ruth , Wild Sarah H. 
Published: July 2020

Abstract
Background: Existing prevention and treatment strategies target the classic types of diabetes yet this approach might not always be appropriate in settings such as rural Africa where atypical phenotypes exist. This study aims to assess the socio-demographic and clinical characteristics of people with diabetes in rural and urban Rwanda.

Methods: Across-sectional, clinic-based study was conducted in which individuals with diabetes mellitus were consecutively recruited from April 2015 to April 2016. Demographic and clinical data were collected from patient interviews, medical files and physical examinations. Chi-square tests and T-tests were used to compare proportions and means between rural and urban residents.
Results: A total of 472 participants were recruited (mean + SD age 40.2±19.1years), including 295 women and 315 rural residents. Compared to urban residents, rural residents had lower levels of education, were more likely to be employed in low-income work and to have limited access to running water and electricity. Diabetes was diagnosed at a younger age in rural residents (mean ± SD 32±18 vs 41±17 years; p < 0.001). Physical inactivity, family history of diabetes and obesity were significantly less prevalent in rural than in urban individuals (44% vs 66%, 14.9% vs 28.7% and 27.6% vs 54.1%, respectively; p < 0.001). The frequency of fruit and vegetable consumption was lower in rural than in urban participants. High waist circumference was more prevalent in urban than in rural women and men (75.3% vs 45.5% and 30% vs 6%, respectively; p< 0.001). History of childhood under-nutrition was more frequent in rural than in urban individuals (22.5% vs 6.4%; p< 0.001).

Conclusions : Characteristics of people with diabetes in rural Rwanda appear to differ from those of individuals with diabetes in urban settings, suggesting that sub-types of diabetes exist in Africa. Generic guidelines for diabetes prevention and management may not be appropriate in different populations.

Key words: diabetes; risk factors; malnutrition; rural; Rwanda
Health Insurance Benefit Package in Iran: A Qualitative Policy Process Analysis
Authors: Mohamadi Efat , Takian Amirhossein , Olyaeemanesh Alireza , Rashidian Arash , Hassanzadeh Ali , Razavi Moaven , Ghazanfari Sadegh 
Published: July 2020

Abstract
Background : Insufficient transparency in prioritization of health services, multiple health insurance organizations with various and not-aligned policies, plus limited resources to provide comprehensive health coverage are among the challenges to design appropriate Health Insurance Benefit Package (HIBP) in Iran. This study aims to analyze Policy Process of Health Insurance Benefit Package in Iran. Method: Data were collected through semi-structured interviews with 25 experts, plus document analysis and observation, from February 2014 until October 2016. Using both deductive and inductive approaches, two independent researchers conducted data content analysis. We used MAXQDA.11 software for data management. Results: We identified 10 main themes, plus 81 sub-themes related to development and implementation of HIBP. These included: lack of transparent criteria for inclusion of services within HIBP, inadequate use of scientific evidence to determine the HIBP, lack of evaluation systems, and weak decision-making process. We propose 11 solutions and 25 policy options to improve the situation. Conclusion: The design and implementation of HIBP did not follow an evidence-based and logical algorithm in Iran. Rather, political and financial influences at the macro level determined the decisions. This is rooted in social, cultural, and economic norms in the country, whereby political and economic factors had the greatest impact on the implementation of HIBP.To define a cost-effective HIBP in Iran, it is pivotal to develop transparent and evidence-based guidelines about the processes and the stewardship of HIBP, which are in line with upstream policies and societal characteristics. In addition, the possible conflict of interests and its harms should be minimized in advance.
Maternal pre-pregnancy body mass index, gestational weight gain and breastfeeding outcomes
Authors: Martin Hayley , Thevenet-Morrison Kelly , Dozier Ann 
Published: July 2020

Abstract
Background: It is well established that mothers with above-normal pre-pregnancy BMI are at increased risk of breastfeeding cessation; however, the impact of pregnancy weight-gain (PWG) is less well-defined. Excess PWG may alter the hormonal preparation of breast tissue for lactation, increase the risk of complications that negatively impact breastfeeding (e.g. Cesarean-section, gestational diabetes), and may make effective latch more difficult to achieve. Methods: Our objective was to determine the impact of PWG and pre-pregnancy BMI on the risk of breastfeeding cessation utilizing the Institute of Medicine’s 2009 recommendations. Cox proportional hazards models were utilized to estimate the risk of cessation of exclusive breastfeeding, and cessation of any breastfeeding among women who initiated exclusive and any breastfeeding, respectively, in a cross sectional sample of survey respondents from a New York county (N=1207). PWG category was interacted with pre-pregnancy BMI (3 levels of pre-pregnancy BMI, 3 levels of PWG). Confounders of the relationship of interest were evaluated using directed acyclic graphs and bivariate analyses; variables not on the proposed causal pathway and associated with the exposure and outcome were included in multivariate models. Results: After adjustment, women of normal and obese pre-pregnancy BMI with greater-than-recommended PWG had 1.39 (1.03-1.86) and 1.48 (1.06-2.07) times the risk of any breastfeeding cessation within the first 3 months postpartum compared to women with normal pre-pregnancy BMI who gained within PWG recommendations. Overweight women with greater-than-recommended PWG were at increased risk of cessation, although not significantly (aHR[95% CI]: 1.29 [0.95 – 1.75]). No significant relationship was observed for exclusive breastfeeding cessation. Conclusions: Pre-pregnancy BMI and PWG may be modifiable risk factors for early breastfeeding cessation. Understanding the mechanism behind this risk should be ascertained by additional studies aimed at understanding the physiological, social, logistical (positioning) and other issues that may lead to early breastfeeding cessation.
Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients - A protocol for the prospective randomised controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study
Authors: Reinhold Simona , Yeginsoy Désirée , Hollinger Alexa , Todorov Atanas , Tintignac Lionel , Sinnreich Michael , Kiss Caroline , Gebhard Caroline Eva , Kovács Balázs , Gysi Bianca , Imwinkelried Lara , Siegemund Martin 
Published: July 2020

Abstract
Background Critically ill patients rapidly develop muscle wasting resulting in sarcopenia, long-term disability and higher mortality. Bolus nutrition (30-60 min period), while having a similar incidence of aspiration as continuous feeding, seems to provide metabolic benefits through increased muscle protein synthesis due to higher leucine peaks. To date, clinical evidence on achievement of nutritional goals and influence of bolus nutrition on skeletal muscle metabolism in ICU patients is lacking. The aim of the Pro BoNo study (Protein Bolus Nutrition) is to compare intermittent and continuous enteral feeding with a specific high-protein formula. We hypothesise that target quantity of protein is reached earlier (within 36 hours) by an intermittent feeding protocol with a favourable influence on muscle protein synthesis.Methods Pro BoNo is a prospective randomised controlled study aiming to compare the impact of intermittent and continuous enteral feeding on preventing muscle wasting in 60 critically ill patients recruited during the first 48 hours after ICU admission. The primary outcome measure is the time until the daily protein target (≥1.5 g protein/kg bodyweight/24h) is achieved. Secondary outcome measures include tolerance of enteral feeding and evolution of glucose, urea and IGF-1. Ultrasound and muscle biopsy of the quadriceps will be performed.Discussion The Basel Pro BoNo study aims to collect innovative data on the effect of intermittent enteral feeding of critically ill patients on muscle wasting.Trial registration ClinicalTrials.gov Identifier: NCT03587870, registered July 16, 2018. Swiss National Clinical Trial Portal identifier: SNCTP000003234, last updated July 24, 2019.
NPF: Network propagation for protein function prediction
Authors: zhao bihai , Zhang Zhihong , Jiang Meiping , Hu Sai , Luo Yingchun , Wang Lei 
Published: July 2020

Abstract
Background: The accurate annotation of protein functions is of great significance in elucidating the phenomena of life, treating disease and developing new medicines. Various methods have been developed to facilitate the prediction of these functions by combining protein interaction networks (PINs) with multi-omics data. However, it is still challenging to make full use of multiple biological to improve the performance of functions annotation.Results: We presented NPF (Network Propagation for Functions prediction), an integrative protein function predicting framework assisted by network propagation and functional module detection, for discovering interacting partners with similar functions to target proteins. NPF leverages knowledge of the protein interaction network architecture and multi-omics data, such as domain annotation and protein complex information, to augment protein-protein functional similarity in a propagation manner. We have verified the great potential of NPF for accurately inferring protein functions. According to the comprehensive evaluation of NPF, it delivered a better performance than other competing methods in terms of leave-one-out cross-validation and ten-fold cross validation.Conclusions: We demonstrated that network propagation, together with multi-omics data, can both discover more partners with similar function, and is unconstricted by the “small-world” feature of protein interaction networks. We conclude that the performance of function prediction depends greatly on whether we can extract and exploit proper functional information of similarity from protein correlations.
FOXM1 modulates docetaxel resistance in prostate cancer by regulating KIF20A
Authors: Yu Hongbo , Xu Zheng , wang weiwan , Zhang Weican , xu zhibin , zhu gangyi , zhang chenyang , lin jianzhong 
Published: July 2020

Abstract
Background：Resistance to docetaxel is an important factor which affects the prognosis in advanced prostate cancer (PCa). The precise mechanisms remain unclear. The transcription factor Forkhead box M1 (FOXM1), participating in cell cycle progress and cell proliferation, has been reported to affect the sensitivity of chemotherapy. The present study aims to explore the role of FOXM1 in docetaxel resistance of PCa and how FOXM1 is associated with kinesin family member 20 A (KIF20A), which has been demonstrated to promote the development of therapeutic resistance in some cancers. Methods: We monitored cell growth by MTT and colony formation assays , and cell apoptosis and cell cycle through flow cytometry. Wound-healing and transwell assays were performed to detect cell migration and invasion. The mRNA and protein expression of gene were analyzed by by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting, respectively. We determined the binding of FOXM1 on the KIF20A promoter by the ChIP assay. Tumorigenicity in nude mice was employed to assess tumorigenicity in vivo. Results: FOXM1 knockdown induced cell apoptosis and G2/M cell cycle arrest, and suppressed cell migration and invasion in docetaxel-resistant PCa cell lines (DU145-DR and VCaP-DR). The opposite trend was found in their parental cells with exogenous FOXM1 overexpression. Furthermore, thiostrepton, a specific inhibitor for FOXM1, significantly attenuated docetaxel resistance in vitro and in vivo. Additionally, we found that FOXM1 and KIF20A were consistently overexpressed and highly correlated in PCa cells and tissues. Further studies demonstrated that FOXM1 regulated the expression of KIF20A at the transcriptional level directly through a Forkhead response element (FHRE) in its promoter. Moreover, KIF20A overexpression could partially reverse the effects of FOXM1 depletion on cell proliferation, cell cycle proteins (cyclinA2, cyclinD1 and cyclinE1) and apoptosis protein (bcl-2 and PARP). Conclusions: our findings suggest that highly expressed FOXM1 may promote docetaxel resistance partly through the induction of KIF20A expression and provide insights into novel chemotherapeutic strategies for docetaxel resistance in PCa.
STUDY PROTOCOL The effect of a telerehabilitation virtual reality intervention on functional upper limb activities in people with multiple sclerosis: A study protocol for the TEAMS pilot randomized controlled trial
Authors: Kalron Alon , Achiron Anat , Pau Massimiliano , Cocco Eleonora 
Published: July 2020

Abstract
Background: Approximately 60% of people with multiple sclerosis (PwMS) suffer from upper limb dysfunction. Our primary goal is to implement a single-blind, randomized control trial (RCT) designed to compare the effectiveness of an 8-week home-based telerehab virtual reality (VR) program with conventional therapy in PwMS with manual dexterity difficulties. Secondary aims include: a) evaluating the impact of the programs on quality of life after the intervention and a follow up 1 month later; and b) evaluating the impact of the programs on adherence and satisfaction. Methods: Twenty-four PwMS will be recruited to the study which will be conducted at two established MS centers: (1) The Regional Center for Diagnosis and Treatment of Multiple Sclerosis, Binaghi Hospital, Cagliari, Italy; (2) The Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Israel. Participants will complete a total of three assessments focusing on upper limb functions. Both groups will receive 16 training sessions focusing on functional upper limb activities. The home-based telerehab VR intervention will comprise a custom-made software program running on a private computer or laptop. PwMS will perform several activities of daily living (ADL) functions associated with self-care, dressing and meal preparation. Conventional therapy will focus on task-related upper-limb treatments while in a sitting position, indicative of the standard care in MS. Following 8-weeks of training, participants will complete a further outcome assessment. The same tests will be conducted 1 month (as a follow-up) after completion of the intervention. Discussion: The outcomes of this study have tremendous potential to improve the quality of evidence and informed decisions of functional upper limb activities in PwMS. If comparable results are found between the treatments in improving upper limb outcomes, this would suggest that PwMS can choose the program that best meets their personal needs, e.g., financial concerns, transportation or accessibility issues. Secondly, this information can be used by healthcare providers and medical professionals in developing upper limb exercise programs that will most likely succeed in PwMS. Trial registration: ClinicalTrials.gov NCT04032431. Registered on 19 July 2019.
Three-dimensional evaluation of mid-facial soft tissue changes after expansion using micro-implant-supported maxillary skeletal expander
Authors: Nguyen Hieu , Shin Jeong Won , Giap Hai-Van , Kim Ki Beom , Chae Hwa Sung , Kim Young Ho , Choi Hae Won 
Published: July 2020

Abstract
The authors have withdrawn this preprint due to author disagreement.
Revealing unique inscriptions of a Nazi collaborator in Doodencel 601 of the Oranjehotel
Authors: Wempe Joost , Brink Rick van den , Mooldijk Esmee , Feirabend Nienke , Wiersma Ruben , Sietsma Jilt , Dik Joris 
Published: July 2020

Abstract
During the Second World War the German occupants of the Netherlands made ample use of the Scheveningen prison near The Hague, popularly nicknamed the Oranjehotel. One former death cell in this infamous prison (Doodencel 601) has been preserved in its original condition, showing wartime inscriptions on the cell walls. Interestingly, a small section of the wall has been given an additional plaster layer, presumably covering inscriptions. Here, we report on the visualization of this enigmatic text, which so far had escaped the reach of historians. Our visualization methodology was threefold. First, we determined the cell-wall stratigraphy and its composition based on a sample cross-section. Second, we prepared a physical model wall, mimicking the layering of the original cell wall. Third, we tested a combination of raking light photography and infrared thermography on the model wall. Applying this methodology on the original wall revealed the inscriptions, including the author’s name Daniël de Blocq van Scheltinga, a prominent Nazi collaborator, as well as a calendar and an important date of his post-war trial in the fall of 1945. Our visualizations flawlessly dovetail with archival findings. Together, they offer an intimate view of an early post-war inmate of the Scheveningen prison, whose message was covered up once the cell was transformed into a war monument in 1946.