bluuebunny/crossref_metadata_2025_split huggingface dataset:
The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population
Authors: Gareton Albane , Tauziède-Espariat Arnault , Dangouloff-Ros Volodia , Roux Alexandre , Saffroy Raphaël , Castel David , Kergrohen Thomas , Fina Fréderic , Figarella-Branger Dominique , Pagès Mélanie , Bourdeaut Franck , Doz François , Puget Stéphanie , Dufour Christelle , Lechapt Emmanuèle , Chrétien Fabrice , Grill Jacques , Varlet Pascale 
Published: November 2019

Abstract
Pilocytic astrocytoma (PA) is the most common pediatric glioma, arising from a single driver MAPK pathway alteration. Classified as a grade I tumor according to the 2016 WHO classification, prognosis is excellent with a 10-year survival rate > 95% after surgery. However, rare cases present with anaplastic features, including an unexpected high mitotic/proliferative index, thus posing a diagnostic and therapeutic challenge. Based on small histomolecular series and case reports, such tumors arising at the time of diagnosis or recurrence have been designated by many names including pilocytic astrocytoma with anaplastic features (PAAF). Recent DNA methylation-profiling studies performed mainly on adult cases have revealed that PAAF exhibit a specific methylation signature, thus constituting a distinct methylation class from typical PA [methylation class anaplastic astrocytoma with piloid features—(MC-AAP)]. However, the diagnostic and prognostic significance of MC-AAP remains to be determined in children. We performed an integrative work on the largest pediatric cohort of PAAF, defined according to strict criteria: morphology compatible with the diagnosis of PA, with or without necrosis, ≥ 4 mitoses for 2.3 mm2, and MAPK pathway alteration. We subjected 31 tumors to clinical, imaging, morphological and molecular analyses, including DNA methylation profiling. We identified only one tumor belonging to the MC-AAP (3%), the others exhibiting a methylation profile typical for PA (77%), IDH-wild-type glioblastoma (7%), and diffuse leptomeningeal glioneuronal tumor (3%), while three cases (10%) did not match to a known DNA methylation class. No significant outcome differences were observed between PAAF with necrosis versus no necrosis (p = 0.07), or with 4–6 mitoses versus 7 or more mitoses (p = 0.857). Our findings argue that the diagnostic histomolecular criteria established for anaplasia in adult PA are not of diagnostic or prognostic value in a pediatric setting. Further extensive and comprehensive integrative studies are necessary to accurately define this exceptional entity in children.
Molecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma
Authors: Xu Jingkai , Huang He , Wang Shangshang , Chen Yanzhen , Yin Xueli , Zhang Xuejun , Zhang Yaohua 
Published: November 2019

Abstract
Cutaneous T cell lymphoma (CTCL) is a rare but potentially devastating primary cutaneous lymphoma. CTCL is characterized by localization of neoplastic T lymphocytes to the skin, with mycosis fungoides (MF) and its leukemic form, Sézary syndrome (SS) being the most common variants. Thymocyte selection-associated high-mobility group box (TOX) gene has been found to be highly expressed in MF and SS. It is reported that higher expression levels of TOX in patients will increase risks of disease progression and poor prognosis. However, the molecular events leading to these abnormalities have not been well understood. To better understand the molecular mechanism underlying TOX-mediated differentially expressed genes (DEGs) in CTCL, and to identify DEGs pathways triggered after knockdown of TOX gene in the CTCL cell line Hut78, we employed two shRNA-mediated lentiviruses to knock down TOX gene in the skin lymphoma cell line HuT78. RNA sequencing (RNAseq) analysis was applied to analyze DEGs, DEGs GO and their corresponding pathways. Knockdown of TOX can induce upregulation of 547 genes and downregulation of 649 genes, respectively. HOXC9 was the most significant downregulated gene. Most DEGs are enriched in malignancies and relate to the Wnt and mTOR signaling pathways, and therefore they can regulate cellular processes and induce different biological regulation. Transcriptome analysis of DEGs after knockdown of TOX in our study provides insights into the mechanism of TOX in CTCL and suggests candidate targets for therapy of CTCL.
Systematic review of matching techniques used in model-driven methodologies
Authors: Somogyi Ferenc Attila , Asztalos Mark 
Published: November 2019

AbstractIn model-driven methodologies, model matching is the process of finding a matching pair for every model element between two or more software models. Model matching is an important task as it is often used while differencing and merging models, which are key processes in version control systems. There are a number of different approaches to model matching, with most of them focusing on different goals, i.e., the accuracy of the matching process, or the generality of the algorithm. Moreover, there exist algorithms that use the textual representations of the models during the matching process. We present a systematic literature review that was carried out to obtain the state-of-the-art of model matching techniques. The search process was conducted based on a well-defined methodology. We have identified a total of 3274 non-duplicate studies, out of which 119 have been included as primary studies for this survey. We present the state-of-the-art of model matching, highlighting the differences between different matching techniques, mainly focusing on text-based and graph-based algorithms. Finally, the main open questions, challenges, and possible future directions in the field of model matching are discussed, also including topics like benchmarking, performance and scalability, and conflict handling.
Novel bacterial control agent tolprocarb enhances systemic acquired resistance in Arabidopsis and rice as a second mode of action
Authors: Hagiwara Hiroyuki , Ogura Rieko , Fukumoto Takeshi , Ohara Toshiaki , Tsuda Mikio , Hiratsuka Kazuyuki 
Published: November 2019

Abstract
The fungicide tolprocarb (TPC) is a melanin biosynthesis inhibitor, but it may also have another mode of action. Here in tests of TPC for inducing plant systemic acquired resistance (SAR), TPC induced promoter activity of the tobacco pathogenesis-related gene PR-1a in Arabidopsis thaliana and genes for PBZ1, β-1,3-glucanase, and chitinase 1 in the defense-related salicylic acid (SA) signaling pathway in rice, but not genes for the jasmonate signaling pathway. Probenazole (PBZ), a commercially used plant defense activator, induced genes in both signaling pathways. The antibacterial activity of TPC was equivalent to that of PBZ. Irrigation with 200 μM TPC prevented growth by Pseudomonas syringae pv. maculicola in A. thaliana, and 30 μM TPC inhibited Xanthomonas oryzae pv. oryzae growth in rice. The results of this study suggest that TPC functions not only as a melanin biosynthesis inhibitor but also as an SAR inducer and is applicable as a novel bacterial control agent that induces SAR activity in both A. thaliana and rice.
Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI
Authors: Ljimani Alexandra , Caroli Anna , Laustsen Christoffer , Francis Susan , Mendichovszky Iosif Alexandru , Bane Octavia , Nery Fabio , Sharma Kanishka , Pohlmann Andreas , Dekkers Ilona A. , Vallee Jean-Paul , Derlin Katja , Notohamiprodjo Mike , Lim Ruth P. , Palmucci Stefano , Serai Suraj D. , Periquito Joao , Wang Zhen Jane , Froeling Martijn , Thoeny Harriet C. , Prasad Pottumarthi , Schneider Moritz , Niendorf Thoralf , Pullens Pim , Sourbron Steven , Sigmund Eric E. 
Published: November 2019

Abstract

Objectives
Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.

Materials and methods
Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.

Results
Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65–74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.

Discussion
The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.
The Impact Performance of Woven-Fabric Thermoplastic and Thermoset Composites Subjected to High-Velocity Soft- and Hard-Impact Loading
Authors: Liu Jun , Liu Haibao , Kaboglu Cihan , Kong Xiangshao , Ding Yuzhe , Chai Hui , Blackman Bamber R. K. , Kinloch Anthony J. , Dear John P. 
Published: November 2019

Abstract
The present paper investigates the impact performance of woven-fabric carbon-fibre composites based upon both thermoplastic- and thermoset-matrix polymers under high-velocity impact loading by conducting gas-gun experiments at impact velocities of up to 100 m.s−1. The carbon-fibre reinforced-polymers (CFRPs) are impacted using soft- (i.e. gelatine) and hard- (i.e. aluminium-alloy) projectiles to simulate either a soft bird-strike or a hard foreign-body impact (e.g. runway debris), respectively, on typical composites employed in civil aircraft. The out-of-plane displacements of the impacted composite specimen are obtained by means of a three-dimensional Digital Image Correlation (DIC) system for the soft-projectile impact on the composites and the extent of damage is assessed both visually and by using portable C-scan equipment. The perforation resistance and energy absorbing capability of the composites are also studied by performing high-velocity impact experiments using the hard-projectile and the resulting extent and type of damage are identified. In addition, a Finite Element (FE) model is also developed to investigate the interaction between the projectile and the composite target.
The choice of institutions to solve cooperation problems: a survey of experimental research
Authors: Dannenberg Astrid , Gallier Carlo 
Published: November 2019

AbstractA growing experimental literature studies the endogenous choice of institutions to solve cooperation problems arising in prisoners’ dilemmas, public goods games, and common pool resource games. Participants in these experiments have the opportunity to influence the rules of the game before they play the game. In this paper, we review the experimental literature of the last 20 years on the choice of institutions and describe what has been learned about the quality and the determinants of institutional choice. Cooperative subjects and subjects with optimistic beliefs about others often vote in favor of the institution. Almost all institutions improve cooperation if they are implemented, but they are not always implemented by the players. Institutional costs, remaining free-riding incentives, and a lack of learning opportunities are identified as the most important barriers. Unresolved cooperation problems, like global climate change, are often characterized by these barriers. The experimental results also show that cooperation tends to be higher under endogenously chosen institutions than exogenously imposed institutions. However, a significant share of players fails to implement the institution and they often perform poorly, which is why we cannot conclude that letting people choose is better than enforcing institutions from outside.
Mortality patterns in long-term survivors of childhood or adolescent central nervous system tumour in Sweden
Authors: Huang Wuqing , Sundquist Jan , Sundquist Kristina , Ji Jianguang 
Published: November 2019

Abstract

Purpose
A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.

Methods
We identified 5-year survivors with childhood or adolescent CNS tumour before age 20 years through the Swedish Cancer Registry. Five controls were randomly matched for each patient to generate the reference group. We retrieved information about death via Cause of Death Register. We calculated the absolute excess risk (AER) of death and the hazard ratio (HR) of death using Cox proportional hazard model.

Results
Long-term survivors with CNS tumour suffered a significant higher risk of overall mortality (HR 6.56, 95% CI 5.71–7.53; AER 5.89, 95% CI 5.03–6.87). The mortality rate declined with the increasing survival time, but it was still higher even after 30 years of follow-up. Malignant neoplasms contributed mostly to late mortality with an AER of 3.75 (95% CI 2.95–4.75). Female survivors, survivors diagnosed at a younger age and survivors with medulloblastoma were particularly strongly associated with a higher risk of death.

Conclusions
Long-term survivors of childhood and adolescent CNS tumours are at a higher risk of late mortality, and the risk of death is affected by gender, age at diagnosis and types of CNS tumour.
Topographic characterization of canine teeth using atomic force microscopy images in nano-scale
Authors: Nezafat Negin Beryani , Ghoranneviss Mahmood , Elahi Seyed Mohammad , Shafiekhani Azizollah , Ghorannevis Zohreh , Solaymani Shahram 
Published: November 2019

Abstract
The purpose of the present study was to investigate a new method to evaluate micro topography and micro morphology of hard tissue of canine teeth using an atomic force microscope (AFM). For this aim, three extracted human canine teeth were applied. The unpolished surfaces were analyzed with AFM images with 15 µm × 5 µm area and their information obtained by power spectral density (PSD) method and fast Fourier transform algorithm. It was observed that PSD analyses extract suitable information about surface morphological variations so that by moving from enamel to cementum, the fractal dimension and surface complexity were increased.
Green waste composting under GORE(R) cover membrane at industrial scale: physico-chemical properties and spectroscopic assessment
Authors: Al-Alawi Mutaz , Szegi Tamas , El Fels Loubna , Hafidi Mohamed , Simon Barbara , Gulyas Miklos 
Published: November 2019

AbstractPurposeGreen waste (GW) composting is of increasing importance to the waste management industry in addition being a useful agricultural product that is rich in nutrient and organic matter (OM). The combination of aerated static windrow with GORE(R) cover membrane and an air-floor aeration system is a relatively new industrial-scale composting technology that has not been previously explored. Therefore, the aim of this research study was to evaluate the effectiveness of composting GW using this new technology.MethodsThe composting process was monitored through changes in the physico-chemical properties,E4/6, and fourier transform infrared (FTIR) spectra.ResultsDisinfection requirements were met by holding composting temperature steady in the thermophilic range for 24 days. The technology greatly improved composting conditions, and final compost product in terms of temperature, pH, electrical conductivity (EC),C/Nratio, OM degradation, nitrogen transformation, humification, and cation exchange capacity (CEC). The FTIR spectra revealed that there was enrichment of aromatic compounds and reduction in aliphatic structures and easily assimilated peptide components by microorganisms, indicating the humification degree increased, the final compost stabilized, and confirming the efficiency of composting. Consequently, the new technology produced a mature compost in only 30 days compared with the standard period of 90–270 days for traditional composting.ConclusionNotably, the new technology may be a sustainable alternative for GW management that converts waste into compost and could be beneficial for agricultural uses.
Environmental Regulation in the Pulp and Paper Industry: Impacts and Challenges
Authors: Söderholm Patrik , Bergquist Ann-Kristin , Söderholm Kristina 
Published: November 2019

AbstractPurpose of ReviewIn this article, we review existing research addressing how environmental regulations have influenced the pulp and paper industry. These regulations appear in different forms and designs and address air and water pollution as well as climate change. The paper devotes particular attention to how various regulations have affected sustainable technological change and the prospects for inducing deep emission reductions without jeopardizing industrial competitiveness and future investments.Recent FindingsExperiences from key pulp and paper regions, not least the Nordic countries, suggest that gradually tightening performance standards have contributed to radical reductions in emissions, e.g., chlorine compounds and biological oxygen demanding agents, and without imposing excessive compliance costs. This outcome can largely be attributed to how the regulations have been designed—and implemented—in practice, as well as to the presence of efficient and legitimate institutions. Long-term emission reduction targets, in combination with extended compliance periods and trustful firm-regulator relationships, contributed to radical technological innovation and permitted radical emission reductions without excessive compliance costs. The development of alternative bleaching technologies is an apt example. In contrast, the impact of carbon pricing schemes, including the EU emissions trading scheme, on carbon dioxide emissions reductions and related technological change in the pulp and paper industry has however been modest. Self-regulation, certification, and community pressure have exerted relatively modest influences on the environmental performance of the industry.SummaryImportant avenues for future research are identified. These include the following: (a) comparative research on how policy mixes in various countries have influenced environmental compliance and innovation; processes; (b) future studies of environmental regulations, their design and implementation, in emerging pulp and paper producing countries, not least China; and (c) research on how environmental regulations can affect ongoing restructurings in the industry towards a broader palette of products in biorefineries.
Tuning Metallic Co0.85Se Quantum Dots/Carbon Hollow Polyhedrons with Tertiary Hierarchical Structure for High-Performance Potassium Ion Batteries
Authors: Liu Zhiwei , Han Kun , Li Ping , Wang Wei , He Donglin , Tan Qiwei , Wang Leying , Li Yang , Qin Mingli , Qu Xuanhui 
Published: November 2019

Abstract
Potassium-ion batteries (KIBs) are a potential candidate to lithium-ion batteries (LIBs) but possess unsatisfactory capacity and rate properties. Herein, the metallic cobalt selenide quantum dots (Co0.85Se-QDs) encapsulated in mesoporous carbon matrix were designed via a direct hydrothermal method. Specifically, the cobalt selenide/carbon composite (Co0.85Se-QDs/C) possesses tertiary hierarchical structure, which is the primary quantum dots, the secondary petals flake, and the tertiary hollow micropolyhedron framework. Co0.85Se-QDs are homogenously embedded into the carbon petals flake, which constitute the hollow polyhedral framework. This unique structure can take the advantages of both nanoscale and microscale features: Co0.85Se-QDs can expand in a multidimensional and ductile carbon matrix and reduce the K-intercalation stress in particle dimensions; the micropetals can restrain the agglomeration of active materials and promote the transportation of potassium ion and electron. In addition, the hollow carbon framework buffers volume expansion, maintains the structural integrity, and increases the electronic conductivity. Benefiting from this tertiary hierarchical structure, outstanding K-storage performance (402 mAh g−1 after 100 cycles at 50 mA g−1) is obtained when Co0.85Se-QDs/C is used as KIBs anode. More importantly, the selenization process in this work is newly reported and can be generally extended to prepare other quantum dots encapsulated in edge-limited frameworks for excellent energy storage.
DEATH AND THE MODERN EMPIRE: THE 1918–19 INFLUENZA EPIDEMIC IN INDIA
Authors: Arnold David 
Published: November 2019

ABSTRACTIn India the 1918–19 influenza pandemic cost at least twelve million lives, more than in any other country; it caused widespread suffering and disrupted the economy and infrastructure. Yet, despite this, and in contrast to the growing literature on recovering the ‘forgotten’ pandemic in other countries, remarkably little was recorded about the epidemic in India at the time or has appeared in the subsequent historiography. An absence of visual evidence is indicative of a more general paucity of contemporary material and first-hand testimony. In seeking to explain this absence, it is argued that, while India was exposed to influenza as a global event and to the effects of its involvement in the Great War, the influenza episode needs to be more fully understood in terms of local conditions. The impact of the disease was overshadowed by the prior encounter with bubonic plague, by military recruitment and the war, and by food shortages and price rises that pushed India to the brink of famine. Subsumed within a dominant narrative of political unrest and economic discontent, the epidemic found scant expression in official documentation, public debate and/or even private correspondence.
Universality of Lower Hybrid Waves at Earth's Magnetopause
Authors: Graham D. B. , Khotyaintsev Yu. V. , Norgren C. , Vaivads A. , André M. , Drake J. F. , Egedal J. , Zhou M. , Le Contel O. , Webster J. M. , Lavraud B. , Kacem I. , Génot V. , Jacquey C. , Rager A. C. , Gershman D. J. , Burch J. L. , Ergun R. E. 
Published: November 2019

AbstractWaves around the lower hybrid frequency are frequently observed at Earth's magnetopause and readily reach very large amplitudes. Determining the properties of lower hybrid waves is crucial because they are thought to contribute to electron and ion heating, cross‐field particle diffusion, anomalous resistivity, and energy transfer between electrons and ions. All these processes could play an important role in magnetic reconnection at the magnetopause and the evolution of the boundary layer. In this paper, the properties of lower hybrid waves at Earth's magnetopause are investigated using the Magnetospheric Multiscale mission. For the first time, the properties of the waves are investigated using fields and direct particle measurements. The highest‐resolution electron moments resolve the velocity and density fluctuations of lower hybrid waves, confirming that electrons remain approximately frozen in at lower hybrid wave frequencies. Using fields and particle moments, the dispersion relation is constructed and the wave‐normal angle is estimated to be close to 90° to the background magnetic field. The waves are shown to have a finite parallel wave vector, suggesting that they can interact with parallel propagating electrons. The observed wave properties are shown to agree with theoretical predictions, the previously used single‐spacecraft method, and four‐spacecraft timing analyses. These results show that single‐spacecraft methods can accurately determine lower hybrid wave properties.