bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of modified electroconvulsive therapy for the refractory depression in older patients
Authors: Jiang Xue , Xie Qin , Liu Lian-Zhong , Zhong Bao-Liang , Si Liang , Fan Fang 
Published: December 2019

Abstract
Background: To explore the clinical efficacy and safety of modified electroconvulsive therapy (MECT) in the treatment of elderly patients with refractory depression. Methods : A total of 43 older patients (18 male and 25 female) with refractory depression were enrolled in our study from March 2014 to February 2015, with the average age of 65±4.8 years old. Modified electroconvulsive therapy (MECT) was performed in these patients after physical examinations and anesthesia procedures. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to assess the efficacy of MECT, and Wechsler Memory Scale (WMS) and mini mental state examination (MMSE) were used to evaluate the memory ability and cognitive function. The preoperative, intraoperative and postoperative care were conducted in patients accompanied by physical diseases. Results: The rate of efficacy was calculated as 67.44% after 4 weeks of MECT treatment. Our results showed HAMA and HAMD scores after 2 weeks of MECT treatment were significantly lower than that before treatment (P<0.05), and the differences were more significant after 4 weeks of MECT treatment (P<0.01). Compared with before treatment, the scores of memory quotient and immediate memory of WMS decreased significantly after 1 week of treatment (P<0.05). However, these events were not be presented with the progress of treatment, except for after 2 weeks of treatment. Our results demonstrated that compared with before treatment, the scores of MMSE significantly increased significantly after 4 weeks of treatment (P<0.05). There were no serious adverse events in all patients, including cardiovascular and cerebrovascular events. Among them, 7 patients had transient blood pressure rise and slight headache, which were relieved spontaneously after resting. Conclusion: MECT is an effective, well tolerated and safe method for the treatment of older patients with refractory depression, which is temporary and reversible for cognitive impairment. MECT can be recommended for the treatment of these patients after conducting effective risk control of comorbid somatic diseases.
Retrospective analysis of thyroid function in drug-free patients with bipolar disorder in China
Authors: Yang Bin , Li Yan Zhong , Wang Qi , Guo Xin Sheng , Zhao Ying , Jiang Feng , Zhang Xiang Yang , Zhang Rui Ling 
Published: December 2019

Abstract
Background Bipolar disorder is a common mental illness with serious consequences. Clinical studies have found that thyroid function may have an impact on patients with bipolar disorder, but there are few relevant studies in China. So this study explores the characteristics of thyroid function in patients with bipolar disorder in China.Methods Using retrospective cohort study and a cross-sectional study, thyroid function tests were performed in inpatients from September 2015 to January 2018 in the Second Affiliated Hospital of Xinxiang Medical University, who were diagnosed with bipolar disorder and were not treated with medications for at least three months before hospitalization.Results We found that the triiodothyronine (T3) and free triiodothyronine (FT3) levels were significantly higher in bipolar mania than in bipolar depression (P < 0.01). The thyroid stimulating hormone (TSH) levels were significantly lower in male than female patients, while the FT3, free thyroxine (FT4) levels were higher in male than female patients (P < 0.01). Patients were divided into two groups: those who used lithium and those who did not. Both groups had a tendency of hypothyroidism after treatment. In addition, the T3 and FT3 levels were significantly higher in manic than in depressive status in those patients who had a transition between mania and depression in 28 patients compared with previous hospitalization (P < 0.05).Conclusion Patients with bipolar disorder may develop thyroid dysfunction at different stages and in male/female sexes.
Emotional repression in patients with chronic inflammatory rheumatism
Authors: Grondin Karine , Lalanne Cécile , Rouanet Stéphanie , Rabin Thibault , Salomon Sarah , Dervaux Alain , Fardellone Patrice , Goeb Vincent 
Published: December 2019

Abstract
Background: This preliminary study was undertaken to assess and compare the psychological profiles of patients with chronic inflammatory rheumatisms (CIRs), rheumatoid arthritis (RA) or spondyloarthritis (SpA), to try to identify a particular emotional profile compared to patients without CIRs. Emotional repression, i.e., a tendency to inhibit the expression of negative feelings and/or unpleasant thoughts, has been the most studied. Methods: This monocenter observational pilot study included patients followed in a university rheumatology department who underwent systematic assessment of different psychological parameters by an experienced psychiatrist. The clinical and biological characteristics of their rheumatisms were collected. Comparisons were performed used Chi 2 or Fisher’s exact tests. Results: Fifty-nine patients were assessed: 47 with CIRs (27 RA and 20 SpA) and 12 non-CIR controls (nine osteoarthritis, and one each viral disease, osteoporosis or osteomalacia). The rates of severe emotional repression, and the rates of severe early life events, were higher in the group of CIR patients than in the control group (respectively P = 0.02, P = 0.02). In contrast, the rates of severe psychological and somatic complaints were significantly higher than in the control group (respectively, P <0.01 and P =0.01). Conclusion: Our results confirm the importance of emotional repression in coping with various traumatic life events which contribute to the etiology and/or evolution of CIRs. They suggest that these patients would probably benefit from psychotherapy in addition to medical management of their CIRs.
The post- noise exposed condition of the normal hearing workers with tinnitus and hyperacusis developed by the chronic occupational noise exposure
Authors: Bae EunBit 
Published: December 2019

Abstract
Background: Noise pollution has been called an invisible killer. It has been a critical issue for the people working in the noisy environments especially in industry and education. This study was conducted to evaluate the differences of neuronal activity between groups, an experimental group is profession in occupational noise environments and a control group is who did not, and all of the subjects had tinnitus or hyperacusis. We used the electroencephalography data from 17 patients. The two experimental subjects were a tinnitus patient and a hyperacusis patient. The fifteen control subjects were seven tinnitus and eight hyperacusis patients and all of the subjects had normal hearing.Results: We compared the brain activity for three states among the groups: after noise-induced state and no sound exposure state for the two experimental subjects, and no sound exposure state for the control group. The activity of the auditory cortex in the experimental group after noise exposure were significantly increased in gamma (p = 0.002) and decreased in delta and theta band. In other brain areas, the rates of the delta, theta, beta 1~3 and gamma for the control group were higher than the experimental subjects for both with or without noise exposure states.Conclusions: Through this study, it was suggested that the professions of tinnitus and hyperacusis with normal hearing in occupational noise environment could be maintain their pathological states by abnormal hyper-activation of the primary and secondary auditory cortex alone.
Identification, evolution and alternative splicing profile analysis of Serine/Arginine-Rich Protein Splicing Factors (SR Proteins) in poplar, Arabidopsis, grape, and papaya
Authors: Wang Hao , Yan Hanwei , He Ting , Wang Yamei , Wang Ruijia , Xiang Yan 
Published: December 2019

Abstract
Alternative splicing (AS) regulates gene expression and produces proteome diversity. Serine/Arginine-Rich Protein Splicing Factors (SR Proteins) are important splicing factors that play significant roles in spliceosome assembly and splicing regulation, and play roles in regulating plant stress. In this report, we analyzed 30 SR genes in Populus trichocarpa, 18 genes in Arabidopsis thaliana, 14 genes in Vitis vinifera and 9 genes in Carica papaya. The SR proteins contained RRM and RS conserved domains, and based on different structural domain organization were divided into six subfamilies (SR, SC, SCL, RS, RSZ and RS2Z). Gene duplication analysis revealed 94 paralogs and 408 orthologs in the four species, and the SR genes had undergone strong purifying selection. A number of stress-related cis-elements (ABRE, LTR, MBS, TC-rich repeats cis-acting element) were identified in the promoters of the SR genes. Microarray and RNA-seq data showed that SR genes expression in different tissues of the four species responded differently to abiotic stress. Poplar, Arabidopsis and grape SR genes had many splice isoforms. Moreover, 26 of 30 poplar SR genes had intron retention (IR) events, and the relative IR rates of 27 intron sites in the poplar SR genes changed significantly under cold, heat, drought and salt stress conditions. This study provides valuable resources for the gene structure, function, and evolution of poplar SR proteins.
New Classification for Bifurcated Mandibular Neural Canal
Authors: Yang Hao , Wu Yue , Hong Pengyu , Hu Yanjia , Tang Zhangui , Li Kun 
Published: December 2019

Abstract
Background: To analyze the occurrence rate of bifurcated neural canal (BMC) by cone beam CT(CBCT) and summarise a new classification for further clinical work and academic communication. Method: Randomly collected the CBCT images of 350 patients. Firstly, we analysed and summarized the BMCs into four types. Second, we did statistics about occurrence. Then we have measured three kinds of distance of Type I and Type II. At last, we compared the advantages and disadvantages about different classifications. Results: Among these 350 patients, we found 110 people with BMC which indicated the occurrence rate of BMC was 31.43%. The most common type was Type I, especially Type I B , and the least was Type III. Vertical distance between the apex of the second molar, the third molar and mandibular canal are 4.36±2.51 mm and 2.45±2.23 mm. Distance from the apex of two molars to the bifurcated spot are 15.87±6.82mm and 9.32±5.37mm. And the distance between the apex and retromolar foramen in Type I are 22.19±5.97mm and 15.82±4.68mm. Conclusion: Comparing with former typing theory, we summarized a new classification which is simpler and more convenient, which should attach scholars’ attention to BMC during clinical work.
Research on Performance Incentive Mechanism of General Practitioners under the Consideration of Reputation Effect
Authors: zhi-qiang Ma , Bin-xin Zhu 
Published: December 2019

Abstract
BackgroundIn China, General practitioners (GPs) have a weaker reputation than specialists, which leads to their low professional identity. Therefore, GPs’ reputation is a bottleneck restricting their participation in skills training and the realization of the service value of community health centre. Because the GPs’ reputation accumulation can only rely on the improvement of personal skills ,it is necessary to combine the improvement of medical skills to the future economic interests of the GPs, and establishing an effective dynamic reputation incentive mechanism. The purpose of this paper is to explore the dynamic reputation incentive mechanism for GPs, and analyze its performance. MethodsIn this paper, a dynamic incentive model of the GPs in two stages under the effect of explicit and implicit reputation is established and solved by using game theory and agent-principal theory. ResultsThe explicit reputation affects GPs’ determined incomes mainly through fixed awards, and the medical effort input in Stage 1 decreases with the performance award in Stage 2 under the reputation mechanism; the increase of the implicit reputation coefficient can improve the medical performance output, the performance award level and the total value of medical service value, and the explicit reputation correction factor plays the opposite role; when the implicit reputation coefficient and explicit reputation correct factor meet certain conditions, the implementation of reputation incentive can lead to the Pareto effect of GPs’ medical effort and performance awards.Conclusion(1) explicit reputation mainly affects GPs’ deterministic income in Stage 2 by changing the fixed benefits; (2) the medical efforts in the Stage 1 depend on the unit performance incentive coefficient in both stages, and show a certain ratchet effect; (3) implicit reputation can help to improve the level of medical efforts at each stage; (4) the reputation uncertainty will reduce the level of medical efforts and unit performance incentive at each stage; (5) when the explicit reputation correction coefficient is lower than a certain threshold, the implement of reputation incentive can realize the Pareto effect of medical efforts.
Clinicopathological and prognostic involvements of MCT1, MCT4 and IL7R in esophageal squamous cell carcinoma
Authors: Zheng Shutao , Liu Qing , Tan Doudou , Shen Tongxue , Zhang Xiao , Han Xiujuan , Lu Xiaomei 
Published: December 2019

Abstract
BackgroundMCTs, short for monocarboxylate transporters, especially MCT1 and MCT4, have been widely touched upon in a variety of immune and cancer cells; however, they have been rarely described in esophageal squamous cell carcinoma (ESCC). IL7R, receptor of interleukin 7, has been shown to operate in several cancers; though, the clinicopathological implication of IL7R expression in ESCC remains less known. MethodsHerein, to understand the clinicopathological involvements of MCT1, MCT4 and IL7R expression in ESCC, immunohistochemistry was performed with ESCC tissue microarray comprising 86 paired ESCC and its matched normal control dots. Subsequently, statistical analyses ensued. ResultsIt was shown that concomitant expression of MCT1, MCT4 and IL7R prevailed in the stromal compartment of ESCC tissues relative to the epithelial. Moreover, up-regulated MCT1 and MCT4 were markedly associated with tumor size; while IL7R was displayed to closely correlate with lymph node metastases and clinical stage. Elevated MCT1, MCT4 and IL7R were strikingly associated with adverse outcome of ESCC. ConclusionsTogether, the data we presented here indicate that MCT1/4 and IL7R were heavily involved in the oncogenesis of ESCC.
Understanding the structure and function of microbial community in acid mine drainage system of Malanjkhand Copper Project, India
Authors: Gupta Abhishek , Dutta Avishek , Sarkar Jayeeta , Panigrahi Mruganka Kumar , Sar Pinaki 
Published: December 2019

Abstract
Background: Acid mine drainage (AMD) is a worldwide environmental menace with its multifaceted extreme nature, yet, it harbors diverse microorganisms with novel lineages and provides new insights into evolution, adaptation and metabolism. With tight coupling between biological and geochemical processes, AMD microbes play crucial roles in biogeochemical cycles and in constant focus for microbial ecology research through quantitative, genome and metagenome based analysis. This study on microbiome of AMD from Malanjkhand copper mine sheds new light of the general assumptions on microbiome emphasizing the roles of local geochemistry in community assemblages and functions using the samples from an unexplored mine.Results: Malanjkhand AMD samples showed a regime of acidic pH with elevated levels of iron, sulfate and heavy metals. 16S rRNA gene amplicon and metagenome sequencing revealed that environmental pH controlled the species abundance, richness and assemblages. Extreme acidic niches were predominated by chemolithotrophic iron- and sulphur- oxidizing taxa (Leptospirillium, Acidithiobacillus, Ferrithrix, Ferrimicrobium, and Metallibacterium) capable of pyrite dissolution. In contrast, the moderately acidic niches were flourished with heterotrophic populations (Sphingomonas, Nitrosomonas, Gemmatimonas, Meiothermus, Novosphingobium, Polaromonas, Desulfurispora, Desulfomonile) involved in diverse carbon and nitrogen metabolism, sulfate and metal reduction. Relative abundance of taxa, co-occurrence, ANOSIM, and PERMANOVA revealed strength of the selective pressure in habitat-specific microbial guilds. Results indicated that individual species’ ability to withstand and flourish under the extreme low pH environment was an important driver for community association, while metabolic interdependencies could be the major factor controlling species interaction within relatively higher pH habitats. Gene abundance in the metagenomes suggested that sulfur/iron oxidizing, carbon fixing, denitrifying, and stress tolerant microbial populations were predominated in both the samples. Metagenome analysis further revealed that only a small set of sulfate/metal reducing populations was abundant in higher pH samples, indicating their potential in natural attenuation of AMD.Conclusion: Our study provided a deeper understanding about the composition and function of microbial communities within AMD highlighting the roles of local geochemistry in regulating species abundance, distribution, and interrelations. Genomic potential of AMD microbiome in withstanding the extremities and role in biogeochemical cycles, affecting metabolism as well as fate of major hazardous constituents was elucidated.
Yeme- İçme Kültürü Mekânları: Pekmezlik/ Pekmez Damı, Antalya Çukurköy Örneği
Authors: Akkaya Ayşe Kübra , Şimşek Tolacı Seda 
Published: December 2019

Birçok farklı kültürel unsura sahip olan
Anadolu’da, yeme içme kültürünün önemli bir ürünü olan pekmez, yapım geleneği
ve bu kültüre ait alanlar/mekânlar, özgün yönleri ile nitelikli olup
değerlendirilmelidirler. Değişken ve dinamik bir kavram olan kültür içerisinde,
bu unsurun mevcut durumunun belirlenmesi için gerçekleştirilmesi gereken öncelikli
basamaklar mevcuttur. Bunlar; gerekli bilgilerin toplanması, tespitlerin
yapılması ve belgelendirme işlemidir. Görsel analiz yöntemi, krokilendirme ve
fotoğraf çekimi ile belgeleme çalışması desteklenmiş, yerel halk ile sözlü
görüşmeler yapılmıştır. Çalışma hedefi
doğrultusunda, bütüncül bir koruma anlayışı ile pekmez yapım geleneği, somut ve
somut olmayan kültürel miras kapsamında ele alınmıştır. Antalya/Çukurköy
yerleşiminde kırsal mimari özellik taşıyan pekmez damları/işlikleri tespit
edilerek, farklı mimari özellikleri kapsamında değerlendirilmiştir. Tespit
edilen 15 adet yapıya dair elde edilen çeşitli veriler, belgelemenin
gerekliliklerine göre; kroki çizimleri, fotoğraflar, tabloların ve tespit
fişlerinin hazırlanması, karşılaştırmalar, vb. farklı şekillerde aktarılmıştır.
ÇOBAN BAYRAMI: SUDAN KOYUN GEÇİRME (DENİZLİ-ÇAL-AŞAĞISEYİT)
Authors: Koyuncu Okca Ayşegül 
Published: December 2019

Çobanlar koyun ve keçi yetiştiriciliğinde
önemli bir yere sahiptir. Sürüyü, yıl boyunca yaylada otlatacak olan kişinin;
sadık, işinin ehli olması istenir. Bir koyun sürüsünün sağlıklı, verimli ve
sahibine yüksek kazanç getirmesinde çoban doğrudan sorumludur. Çok çeşitli halk
eğlenceleri bulunan Türk kültüründe özellikle çobanların ve hayvanların aktif
olarak yer aldığı, doğadaki değişimleri bolluk ve berekete çevirmek için bazı
törenler ile kutlamalar yapılmıştır. Eğlence temelli olarak düzenlenen
etkinliklerde bir oyun aracı olarak yer alan hayvanlar insanlar ile olan
bağlarını da sergilerler. Bu
çalışmada Denizli-Çal-Aşağıseyit’de düzenlenen çoban bayramı olan sudan koyun
geçirme etkinliği detaylı bir şekilde açıklanarak Türk kültüründeki yeri ve
önemine dikkat çekilmiştir. Çalışmanın gerçekleşmesi için yöntem anlayışı ışığında
amaca ulaşmada gerekli araçlar olan literatür taraması, yerinde gözlem,
derinlemesine mülakat ve alan araştırması teknikleri kullanılmıştır. Sudan
koyun geçirme etkinliğinin her aşaması fotoğraflar ile belgelenerek çalışmayı
destekleyici şekilde metin kısmına eklenmiştir.
Somut Olmayan Kültürel Miras Perspektifinden Analar, Tanrıçalar ve Anadolu
Authors: Kafkas Metin Erkan 
Published: December 2019

Özİnsanlık tarihi uygarlık seviyesine MÖ
10.000-8000 yıl önce yerleşik düzene geçerek ulaşmıştır. En eski ve en ileri
düzeyde olan yerleşimlerden Çayönü, Çatalhöyük, Hacılar, Norşuntepe ve Köşk
Höyük bölgelerinde 7000-8000 yıl önce yapılmış, ibadet nesnesi olarak kullanılan
heykelcikler mevcuttur. Bu heykelcikler, binlerce yıl sonrasının insanlarının
ellerinde bulunmakta, bugün hala “Tanrı
Ana” heykellerinden bahsetmekteyiz. Somut olmayan Kültürel Mirasımız
Perspektifinden Anadolu’ya bakıldığında benzersiz bir coğrafyanın, kültürel
hazinenin mirasçıları olarak bu topraklarda yaşamaya devam etmekteyiz.
Anadolu’da Tanrı Ana heykelcikleri boyutları ve soyutlama düzeyleri bakımından
günümüz ürünleri kadar çağdaş bir estetik yansıtmakta, fakat Tanrı Ana, Bereket
Ana ya da Ana Tanrıça kavramlarının anlamları maalesef yeterli kadar
bilinmemekte, bu kavramlara hak ettiği değer verilmemektedir.Anahtar Kelimeler:
“Ana Tanrıça”, “Tanrı Ana”, “Bereket Ana”,
Anadolu Abstract

Human history has reached the level of
civilization 10.000- 8000 years ago by settling. Some of the oldest and most
advanced settlements in Çayönü, Çatalhöyük, Hacılar, Norşuntepe and Köşk Höyük
have statues that were built 7000-8000 years ago and used as worship objects.
These statuettes are in the hands of people after thousands of years and today
we are still talking about “Ana Tanrı” statues. From the perspective of our
intangible cultural heritage we continue to live in Anatolia as the heirs of a unique
geography and cultural treasure. “Tanrı Ana” figurines in Anatolia reflect a
contemporary aesthetic in terms of their dimensions and abstraction levels as a
contemporary products but unfortunately the meanings of “Tanrı Ana”, “Bereket
Ana” or “Ana Tanrıça” are not known enough and they are not given the value
they deserve.
Isparta Evlenme Adetleri
Authors: Çeliker Deniz , Genç Mustafa 
Published: December 2019

Kültürümüzde evlenme, sadece kız ve erkek için
değil aynı zamanda iki tarafın aileleri içinde yeni akrabalık bağlarının
kurulduğu kutlu bir süreçtir. Genel olarak her yörede kız isteme, söz, nişan ve
düğün törenlerinin sıralaması aynıdır. Ancak, törenlerin gün sayısı, hangi
günler yapılacağı, bu günlerde yapılan işler ve günlere verilen isimler, bu
süreçte yerine getirilen adetler, yapılan ikramlar, çeyiz ve ağırlık olarak
verilen eşyalar, giyim-kuşam, sözlü kültür unsurları, törenlerin yapıldığı
toplumun kültürüne göre şekillenerek bugüne gelmiştir. Geleneksel evlenme ritüelleri
hangi yörede olursa olsun meşakkatli ve bir o kadar biricik kutlamalardır.
Birçok yörede modern zamanın getirdiği teknolojik kolaylıklar, moda vb.
unsurlar ile geleneksel evlenme ritüelleri değişime uğramış hatta bazı yerlerde
unutulmaya yüz tutmuştur. Ancak Isparta; ilçeleri, köy ve kasabaları ile
evlenme adetlerinin geçmişten bugüne devam ettirmeye çalışan bir ilimizdir. Bu çalışmada Isparta ili evlenme adetleri;
kız isteme, söz, nişan ve düğün süreçleri ilçelerdeki farklı uygulamalarıyla
tanıtılmaya çalışılmıştır.