bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Gods Become Bureaucrats
Authors: Cole Richard 
Published: April 2020

AbstractEven gods are not always above bureaucracy. Societies very different from each other have entertained the idea that the heavens might be arranged much like an earthly bureaucracy, or that mythological beings might exercise their power in a way that makes them resembles bureaucrats. The best-known case is the Chinese “celestial bureaucracy,” but the idea is also found in (to take nearly random examples) Ancient Near Eastern cosmology, the Hebrew Bible, Late Antiquity, and modern popular culture. The primary sources discussed in this essay pertain to an area of history where bureaucracy was historically underdeveloped, namely medieval Scandinavia. Beginning with the Glavendrup runestone from the 900s, I examine a way of thinking about divine power that seems blissfully bureaucracy-free. Moving forwards in time to Adam of Bremen’s description of the temple at Uppsala (1040s–1070s), I find traces of a tentative, half-formed bureaucracy in the fading embers of Scandinavian paganism. In the 1220s, well into the Christian era, I find Snorri Sturluson concocting a version of Old Norse myth which proposes a novel resolution between the non-bureaucratic origins of his mythological corpus and the burgeoning bureacratization of High Medieval Norway. Although my focus is on medieval Scandinavia, transhistorical comparisons are frequently drawn with mythological bureaucrats from other times and places. In closing, I synthesise this comparative material with historical and anthropological theories of the relationship between bureaucracy and the divine.
Trichotillomania—psychopathological correlates and associations with health-related quality of life in a large sample
Authors: Bezerra Andre P. , Machado Myrela O. , Maes Michel , Marazziti Donatella , Nunes-Neto Paulo R. , Solmi Marco , Firth Joseph , Husain M. Ishrat , Brunoni Andre R. , Kurdyak Paul , Smith Lee , Alavi Afsaneh , Piguet Vincent , Carvalho André F. 
Published: April 2020

AbstractBackgroundRelatively few studies have assessed the prevalence, correlates, and independent impact on quality of life (QoL) of trichotillomania (TTM) in large samples.MethodsConsecutive participants (N = 7639) were recruited from a cross-sectional web-based study. Sociodemographic data were collected and several validated self-reported mental health measures were completed (Minnesota Impulsive Disorders Interview, Hypomania checklist, Fagerström Test for Nicotine Dependence, Alcohol Use Disorders Identification Test, Early Trauma Inventory Self Report–Short Form, and the Symptom Checklist-90–Revised Inventory). Health-related QoL was assessed with the World Health Organization QoL abbreviated scale (WHOQOL-Bref). Multivariable models adjusted associations to potential confounders.ResultsThe sample was predominantly composed of young females (71.3%; mean age: 27.2 ± 7.9 years). The prevalence of probable TTM was 1.4% (95% confidence intervals [CI]: 1.2-1.7), and was more common among females. Participants with probable TTM had a greater likelihood of having co-occurring probable depression (adjusted odds ratio [ORadj] = 1.744; 95% CI: 1.187-2.560), tobacco (ORadj = 2.250; 95% CI: 1.191-4.250), and alcohol (ORadj = 1.751; 95% CI: 1.169-2.621) use disorders. Probable TTM was also independently associated with suicidal ideation (ORadj = 1.917; 95% CI: 1.224-3.003) and exposure to childhood sexual abuse (ORadj = 1.221; 95% CI: 1.098-1.358). In addition, a positive screen for TTM had more impaired physical and mental QoL.ConclusionsTTM was associated with a positive screen for several psychiatric comorbidities as well as impaired physical and psychological QoL. Efforts towards the recognition and treatment of TTM across psycho-dermatology services are warranted.
IAPT and the internet: the current and future role of therapist-guided internet interventions within routine care settings
Authors: Thew Graham R. 
Published: April 2020

Abstract
Compared with the traditional face-to-face format, therapist-guided internet interventions offer a different approach to supporting clients in learning skills to manage and overcome mental health difficulties. Such interventions are already in use within IAPT (Improving Access to Psychological Therapies) and other routine care settings, but given their potential to deliver treatment more efficiently and therefore increase availability and access to evidence-based interventions, their use is likely to increase significantly over the coming years. This article outlines what is meant by therapist-guided internet interventions and why an online format is thought to be advantageous for clients, therapists, services, and communities more broadly. It reviews the current evidence in the context of common therapist beliefs about internet-based treatment. It aims to identify gaps where further research is required, particularly in relation to the broader implementation of these treatments in IAPT and other routine clinical services. Specifically, it emphasises the importance of choosing the right programmes, providing adequate therapist training in their use, and considering practical and organisational issues, all of which are likely to determine the success of implementation efforts.

Key learning aims

(1)
To understand what therapist-guided internet interventions are and their potential advantages.

(2)
To understand the current evidence base for these interventions.

(3)
To learn where further research is needed with regard to both the interventions themselves, and to their broader implementation in IAPT.
European agricultural policy requires a stronger performance framework to achieve the Sustainable Development Goals
Authors: Scown Murray W. , Nicholas Kimberly A. 
Published: April 2020

Non-technical summary
Agriculture provides many benefits to people, such as producing food and creating jobs in rural areas, but it can also have negative impacts on the environment. We analysed existing monitoring indicators for the European Union's Common Agricultural Policy (CAP) to evaluate whether the CAP is effectively achieving multiple social and environmental goals. We found that the current CAP monitoring system is unable to balance many potentially competing goals because its indicators are biased towards a few objectives. We suggest the European Union and its Member States adopt a broader set of indicators covering clear targets when the policy is reformed after 2020.
On the Production of Ionospheric Irregularities Via Kelvin‐Helmholtz Instability Associated with Cusp Flow Channels
Authors: Spicher Andres , Deshpande Kshitija , Jin Yaqi , Oksavik Kjellmar , Zettergren Matthew D. , Clausen Lasse B. N. , Moen Jøran I. , Hairston Marc R. , Baddeley Lisa 
Published: April 2020

AbstractWe present a multi‐instrument multiscale study of a channel of enhanced, inhomogeneous flow in the cusp ionosphere occurring on November 30, 2014. We provide evidence that strong Global Navigation Satellite System (GNSS) phase scintillations indices (σϕ>0.5 rad) can arise from such events, indicating that they are important in the context of space weather impacts on technology. We compare in detail two‐dimensional maps of ionospheric density, velocity, and temperatures obtained by the European Incoherent Scatter Scientific Association Svalbard Radar with scintillation indices detected from a network of four GNSS receivers around Svalbard and examine the different sources of free energy for irregularity creation. We observe that the strongest phase scintillations occur on the poleward side of the flow channel in a region of sheared plasma motion and structured low‐energy particle precipitation. As inhomogeneous plasma flows are evident in our observations, we perform a quantitative, nonlinear analysis of the Kelvin–Helmholtz instability (KHI) and its impact on phase scintillations using numerical simulations from the first principles‐based Geospace Environment Model of Ion‐Neutral Interactions and Satellite‐beacon Ionospheric‐scintillation Global Model of the upper Atmosphere. Using representative values consistent with the radar data, we show that KHI can efficiently create density structures along with considerable scintillations and is thus likely to contribute significantly under similar conditions, which are frequent in the cusp.
Intergeneric Differences in Trophic Status of Scleractinian Corals From Weizhou Island, Northern South China Sea: Implication for Their Different Environmental Stress Tolerance
Authors: Xu Shendong , Yu Kefu , Zhang Zhinan , Chen Biao , Qin Zhenjun , Huang Xueyong , Jiang Wei , Wang Yixuan , Wang Yinghui 
Published: April 2020

AbstractThe knowledges of trophic status (i.e., autotrophy/heterotrophy) of corals are helpful for understanding the mechanisms driving their environmental stress tolerance and bleaching resilience. We conducted this study to elucidate the differences in trophic status among corals of different genera and then explore the implication of trophic status for their different environmental stress tolerance. In this study, 117 coral samples including five genera (i.e., relatively stress‐tolerant massive genera Porites, Favites, and Favia and relatively vulnerable plating genus Pavona and branching genus Acropora) were collected from Weizhou Island, northern South China Sea. The symbiotic zooxanthellae density, δ13C of host tissues (δ13Ch), and symbiotic zooxanthellae (δ13Cz) were measured. Besides, the difference in values between δ13Ch and δ13Cz (i.e., △h‐z 13C) was analyzed. Our results indicated that both zooxanthellae density and δ13Cz values of Porites, Favites, and Favia are higher than that of Pavona and Acropora and indicate that autotrophic photosynthesis intensity of symbiotic zooxanthellae of Porites, Favites, and Favia is higher than that of Pavona and Acropora. Besides, both δ13Ch and △h‐z 13C of Porites, Favites, and Favia are lower than that of Pavona and Acropora and indicate a higher contribution of heterotrophic predation to the coral host of Porites, Favites, and Favia. These comparisons suggest that trophic status of relatively stress‐tolerant Porites, Favites, and Favia is more plasticity than vulnerable Pavona and Acropora, which is conducive to maintain a positive energy budget. This is one of important factors leading to different environmental stress tolerance and bleaching resilience among corals of different genera.
An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy
Authors: Liu Conghui , Cao Yu , Cheng Yaru , Wang Dongdong , Xu Tailin , Su Lei , Zhang Xueji , Dong Haifeng 
Published: April 2020

AbstractThe therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage of oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H2O2) in chemodynamic therapy (CDT). Here, we report a H2O2/O2 self-supplying nanoagent, (MSNs@CaO2-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO2) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet oxygen and emits heat to melt the LA. The exposed CaO2 reacts with water to produce O2 and H2O2 for hypoxia-relieved ICG-mediated PDT and H2O2-supplying MSN-based CDT, acting as an open source strategy for ROS production. Additionally, the MSNs-induced glutathione depletion protects ROS from scavenging, termed reduce expenditure. This open source and reduce expenditure strategy is effective in inhibiting tumor growth both in vitro and in vivo, and significantly improves ROS generation efficiency from multi-level for ROS-involved cancer therapies.
Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity
Authors: Francelle Laetitia , Outeiro Tiago F. , Rappold Gudrun A. 
Published: April 2020

AbstractThe neuropathological hallmarks of Parkinson’s disease include preferential vulnerability of dopaminergic neurons of the substantia nigra pars compacta, and accumulation of intraneuronal protein inclusions known as Lewy bodies. These inclusions contain, among other proteins, aggregated alpha-synuclein and histone deacetylase 6 (HDAC6). In our study we found that selective inhibition of HDAC6 activity by Tubastatin A has protective effects in a rat model of Parkinson’s disease. We provide evidence that this protection may be due to the activation of chaperone-mediated autophagy through the up-regulation of key members of this pathway. Moreover, Tubastatin A significantly inhibited the expression of a toxic form of alpha-synuclein that is phosphorylated at serine position 129. Tubastatin A treatment also permitted to partially modulate neuroinflammation. Taken together, our study highlights the neuroprotective effects of Tubastatin A in a rat model of Parkinson’s disease and provides mechanistic insight in Tubastatin A-mediated protection against alpha-synuclein toxicity and substantia nigra degeneration. These findings are of potential therapeutic value in Parkinson’s disease and other synucleinopathies.
Pre-operative simulation using a three-dimensional printing model for surgical treatment of old and complex tibial plateau fractures
Authors: Shen Sheng , Wang PeiZhao , Li XiaoYong , Han Xu , Tan HongLue 
Published: April 2020

AbstractTo investigate the clinical efficacy of pre-operative simulation using a three-dimensional (3D) printing model for surgical treatment of old and complex tibial plateau fractures. Forty-two patients with old and complex tibial plateau fractures were retrospectively reviewed from January 2014 to January 2018, which were divided into a conventional planning group (n = 22) and a planning with 3D printing group (n = 20). In the planning with 3D printing group, preoperative equal-ratio fracture models prepared using the 3D printing technique were used to perform pre-operative simulation and guide the real surgical operation. In the conventional planning group, the operation was performed based on pre-operative computed tomography (CT) images. Surgery duration, blood loss and the number of fluoroscopy during operations were recorded. During follow-up, the quality of fracture reduction and complications were also recorded. Knee functions were evaluated using the hospital for special surgery (HSS) scoring system. The operation time, blood loss and the number of fluoroscopy during operation in the planning with 3D printing group were less than that in the conventional planning group (P < 0.01). All patients were followed up for mean of 24.38 ± 7.62 months. The rate of excellent fracture reduction in the planning with 3D printing group and conventional planning group was 75% and 45.45%, respectively (P = 0.05). The complication rate was 15% in the planning with 3D printing group and 31.82% in the conventional planning group. At the final follow-up evaluation, the mean HSS score was 86.05 ± 7.67 in the planning with 3D printing group and 79.09 ± 6.75 in the conventional planning group (P = 0.003). The rate of excellent results in the planning with 3D printing group was 70% and in the conventional planning group was 45.45% (P = 0.083). In conclusion, pre-operative simulation using a 3D printing model may be helpful for the treatment of old and complex tibial plateau fractures, which may be conducive to the pre-operative planning and to making the surgical procedure accurate and personalized. However, its clinical effectiveness need to be further assessed by a prospective randomized-controlled study.
Probing the structural evolution and electronic properties of divalent metal Be2Mgn clusters from small to medium-size
Authors: Zhang Feige , Zhang Hairong , Xin Wang , Chen Peng , Hu Yanfei , Zhang Xiaoyi , Zhao Yaru 
Published: April 2020

AbstractBimetallic clusters have aroused increased attention because of the ability to tune their own properties by changing size, shape, and doping. In present work, a structural search of the global minimum for divalent bimetal Be2Mgn (n = 1–20) clusters are performed by utilizing CALYPSO structural searching method with subsequent DFT optimization. We investigate the evolution of geometries, electronic properties, and nature of bonding from small to medium-sized clusters. It is found that the structural transition from hollow 3D structures to filled cage-like frameworks emerges at n = 10 for Be2Mgn clusters, which is obviously earlier than that of Mgn clusters. The Be atoms prefer the surface sites in small cluster size, then one Be atom tend to embed itself inside the magnesium motif. At the number of Mg larger than eighteen, two Be atoms have been completely encapsulated by caged magnesium frameworks. In all Be2Mgn clusters, the partial charge transfer from Mg to Be takes place. An increase in the occupations of the Be-2p and Mg-3p orbitals reveals the increasing metallic behavior of Be2Mgn clusters. The analysis of stability shows that the cluster stability can be enhanced by Be atoms doping and the Be2Mg8 cluster possesses robust stability across the cluster size range of n = 1–20. There is s-p hybridization between the Be and Mg atoms leading to stronger Be-Mg bonds in Be2Mg8 cluster. This finding is supported by the multi-center bonds and Mayer bond order analysis.
Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans
Authors: Son Sung-Hun , Son Ye-Eun , Cho He-Jin , Chen Wanping , Lee Mi-Kyung , Kim Lee-Han , Han Dong-Min , Park Hee-Soo 
Published: April 2020

AbstractThe homeobox domain-containing transcription factors play an important role in the growth, development, and secondary metabolism in fungi and other eukaryotes. In this study, we characterized the roles of the genes coding for homeobox-type proteins in the model organism Aspergillus nidulans. To examine their roles in A. nidulans, the deletion mutant strains for each gene coding for homeobox-type protein were generated, and their phenotypes were examined. Phenotypic analyses revealed that two homeobox proteins, HbxA and HbxB, were required for conidia production. Deletion of hbxA caused abnormal conidiophore production, decreased the number of conidia in both light and dark conditions, and decreased the size of cleistothecia structures. Overexpressing hbxA enhanced the production of asexual spores and formation of conidiophore under the liquid submerged conditions. The hbxB deletion mutant strains exhibited decreased asexual spore production but increased cleistothecia production. The absence of hbxB decreased the trehalose content in asexual spores and increased their sensitivity against thermal and oxidative stresses. The ΔhbxA strains produced more sterigmatocystin, which was decreased in the ΔhbxB strain. Overall, our results show that HbxA and HbxB play crucial roles in the differentiation and secondary metabolism of the fungus A. nidulans.
Periodic strip loaded reconfigurable half‐mode substrate integrated waveguide‐based leaky wave antennas
Authors: Singh M. , Ghosh B. 
Published: April 2020

In this Letter, a reconfigurable half‐mode substrate integrated waveguide (HMSIW)‐based leaky‐wave antenna (LWA) configuration with its edge loaded with the periodic strips is investigated. A good impedance matching is obtained using the loaded configuration. A microstrip line with a tapered‐line transition is used to feed the proposed antenna structure. Beam scanning of 24°–66° in the frequency band 9.07–11.04 GHz is achieved with the maximum gain of 14.58 dBi at the frequency 10.07 GHz with a corresponding beam direction of 48°. Thereafter, the edge of the strips is loaded in the middle with variable capacitors connected through narrow stubs to scan the beam at a fixed frequency. The variation in reflection and transmission coefficients, beam angle and antenna gain with variation in the capacitor value for the loaded configuration is investigated.
Responding to COVID-19: The UW Medicine Information Technology Services Experience
Authors: Grange Elisha S. , Neil Eric J. , Stoffel Michelle , Singh Angad P. , Tseng Ethan , Resco-Summers Kelly , Fellner B. Jane , Lynch John B. , Mathias Patrick C. , Mauritz-Miller Kristal , Sutton Paul R. , Leu Michael G. 
Published: April 2020

Abstract
Background UW Medicine was one of the first health systems to encounter and treat COVID-19 patients in the United States, starting in late February 2020.
Objective Here we describe the rapid rollout of capabilities by UW Medicine Information Technology Services (ITS) to support our clinical response to the COVID-19 pandemic and provide recommendations for health systems to urgently consider, as they plan their own response to this and potentially other future pandemics.
Methods Our recommendations include establishing a hospital incident command structure that includes tight integration with IT, creating automated dashboards for incident command, optimizing emergency communication to staff and patients, and preparing human resources, security, other policies, and equipment to support the transition of all nonessential staff to telework.We describe how UW Medicine quickly expanded telemedicine capabilities to include most primary care providers and increasing numbers of specialty providers. We look at how we managed expedited change control processes to quickly update electronic health records (EHR) with new COVID-19 laboratory and clinical workflows. We also examine the integration of new technology such as tele–intensive care (ICU) equipment and improved integration with teleconferencing software into our EHR. To support the rapid preparation for COVID-19 at other health systems, we include samples of the UW Medicine's COVID-19 order set, COVID-19 documentation template, dashboard metric categories, and a list of the top 10 things your health care IT organization can do now to prepare.
Conclusion The COVID-19 response requires new and expedited ways of approaching ITS support to clinical needs. UW Medicine ITS leadership hope that by quickly sharing our nimble response to clinical and operational requests, we can help other systems prepare to respond to this public health emergency.
The Impact of Access to Addiction Specialist on Attitudes, Beliefs and Hospital-Based Opioid Use Disorder Related Care: A Survey of Hospitalist Physicians
Authors: Calcaterra Susan L. , Binswanger Ingrid A. , Edelman E. Jennifer , McNair Bryan K. , Wakeman Sarah E. , O'Connor Patrick G. 
Published: April 2020

Background Hospitalizations for complications related to opioid use disorder (OUD) are increasing. Hospitalists care for most hospitalized patients in the United States, yet little is known about their attitudes, beliefs, and clinical practices regarding OUD-related care. Methods We distributed an online survey to hospitalists in the United States to measure how access to addiction specialists affected attitudes and beliefs regarding hospital-based OUD care, OUD screening practices, naloxone prescribing, and buprenorphine initiation. Results Among 262 respondents, 67.9% ( n = 178) reported having access to addiction specialists. While 84.5% ( n = 221) reported often or always caring for patients with OUD, 48.2% ( n = 126) rarely or never screened for OUD, 57.1% ( n = 149) rarely or never prescribed or recommended naloxone as harm reduction, and 88.9% ( n = 233) rarely or never initiated buprenorphine. In multivariable analyses, compared to hospitalists without access to addiction specialists, hospitalist with access to addiction specialists were more likely to feel supported to screen and refer patients to treatment (aOR = 4.4, 95% CI 2.1 − 9.1; ρ < 0.001), to be aware of local treatment resources (aOR = 3.4, 95% CI 1.8 − 6.3; ρ < 0.001), and refer patients to treatment (aOR = 3.0, 95% CI 1.7 − 5.6; ρ < 0.001). Conclusions Many hospitalists do not provide life-saving treatment to patients with OUD. Access to addiction specialists may increase provision of OUD-related care by hospitalists.