bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastroenterologist-Lead Management of Iron Deficiency Anemia in Inflammatory Bowel Disease Is Effective, Safe, and May Increase Quality of Life
Authors: Coe Christopher L , Meyers Matthew H , Beaulieu Dawn B , Scoville Elizabeth , Schwartz David A , Horst Sara N , Dalal Robin L 
Published: June 2020

AbstractBackgroundThe effectiveness and safety of gastroenterologist (GI)-lead treatment of iron deficiency anemia (IDA) in inflammatory bowel disease (IBD) have not been well-studied.MethodsA retrospective chart review of patients with IBD, IDA, and evidence of treatment with iron at a tertiary IBD center was conducted.ResultsIn 351 patients, hemoglobin and quality of life scores increased significantly after treatment with iron. Twelve of 341 patients treated with intravenous iron had an adverse effect. Twenty-seven patients required a hematology referral.ConclusionGIs should consider treating patients with IBD and IDA with intravenous iron as it is safe and effective.
COVID-19 Pandemic: Which IBD Patients Need to Be Scoped—Who Gets Scoped Now, Who Can Wait, and how to Resume to Normal
Authors: Ng Siew C , Mak Joyce Wing Yan , Hitz Lara , Chowers Yehuda , Bernstein Charles N , Silverberg Mark S 
Published: June 2020

Abstract
Endoscopy is an essential component in the management of inflammatory bowel disease [IBD]. There is a risk of SARS-CoV-2 transmission during endoscopic procedures. The International Organization for the study of IBD [IOIBD] has developed 11 position statements, based on an online survey, that focus on how to prioritise endoscopies in IBD patients during the COVID-19 pandemic, alternative modes for disease monitoring, and ways to triage the high number of postponed endoscopies after the pandemic. We propose to pre-screen patients for suspected or confirmed COVID-19 and test for SARS-CoV-2 before endoscopy if available. High priority endoscopies during pandemic include acute gastrointestinal bleed, acute severe ulcerative colitis, new IBD diagnosis, cholangitis in primary sclerosing cholangitis, and partial bowel obstruction. Alternative modes of monitoring using clinical symptoms, serum inflammatory markers, and faecal calprotectin should be considered during the pandemic. Prioritising access to endoscopy in the post-pandemic period should be guided by control of COVID-19 in the local community and availability of manpower and personal protective equipment. Endoscopy should be considered within 3 months after the pandemic for patients with a past history of dysplasia and endoscopic resection for dysplastic lesion. Endoscopy should be considered 3–6 months after the pandemic for assessment of postoperative recurrence or new biologic initiation. Endoscopy can be postponed until after 6 months of pandemic for routine IBD surveillance and assessment of mucosal healing.
P1425Complication rate and incidence of esophageal injury after minimally invasive convergent procedure for treatment of atrial fibrillation
Authors: Prolic Kalinsek T , Gersak B , Jan M 
Published: June 2020

Abstract

Funding Acknowledgements
None

Introduction
Convergent procedure is a minimally invasive surgical approach for treatment of atrial fibrillation (AF) combining epicardial and endocardial radiofrequency (RF) ablation. However, there is conflicting data regarding the rate of major complications after convergent treatment of AF. Apart from common complications the esophageal injury incidence after convergent procedure is not well documented.

Purpose
Our aim was to assess major complication occurrence after convergent procedure with additional emphasis on the incidence of esophageal injury.

Methods
One hundred forty-seven consecutive patients (113 male, mean age 59 ± 9 years, BMI 29 ± 5 kg/m2) with persistent (122, 83%) and paroxysmal (25, 17%) AF were treated with convergent procedure that included epicardial RF ablation with coagulation devices (12 lesions, each for 90 s, with 30 W power), combined with endocardial RF catheter ablation for pulmonary vein isolation. The approach for epicardial ablation was diaphragmatic pericardial window through subxiphoid incision. Infusion of cooled saline into the pericardial space during epicardial ablations and monitoring of esophageal temperature with temperature probe were additional precautions to avoid esophageal overheating. All patients had endoscopy of the esophagus at least 2 days after the procedure to assess for presence of esophageal injury. Adverse events resulting in additional intervention or causing long-term disability were defined as major complication.

Results
During short-term follow-up (minimum of 5 months) major complication rate was 6.1%. Three patients had cardiac tamponade, 4 had abdominal bleeding, 1 had ischemic stroke and 1 had arterial pseudoaneurysm. Esophageal mucosal lesions were observed in 11 patients (7.5%) that did not result in major complication. All lesions were followed with additional endoscopies and resolved without any intervention.

Conclusions
Complication rate after minimally invasive convergent procedure for treatment of AF in our patient cohort is low. Prevention of esophageal overheating resulted in absence of major esophageal injury.
307Clinical outcomes of pacing induced cardiomyopathy in patients with preserved left ventricular systolic function and atrioventricular block
Authors: Dor O , Haim M , Barrett O , Novack V , Konstantino Y 
Published: June 2020

Abstract

Funding Acknowledgements
None

Background
Patients with preserved LVEF and atrioventricular block (AVB) who are anticipated for high-burden of right ventricular (RV) pacing possess a risk to develop pacing induced cardiomyopathy (PICM).

Aims
To evaluate the incidence and outcomes of RV-PICM in this patient"s population.

Methods
1013 patients with AVB underwent first time pacemaker (PM) implantation between 2002 and 2016. A total of 203 patients with normal LVEF were included. Follow-up echocardiography was examined for a decrease in LVEF &gt; 10%. Alternative causes for cardiomyopathy were excluded. Patient"s characteristics, mortality and hospitalizations for heart failure (HF) were compared between the PICM and non-PICM groups.

Results
51 patients (25%) developed PICM, with 22 patients (11%) showing LVEF &lt; 40%. During mean follow-up of 49.2 months, the risk of HF hospitalization or all-cause mortality was significantly higher in the PICM group (35.3% vs. 19.1%, p = 0.009). LVEDD was independently associated with PICM (HR = 1.10, 95% CI: 1.03-1.17, p = 0.01) and CAD was nearly associated with PICM (HR = 2.19, 95% CI: 0.98-4.90, p = 0.06).

Conclusions
The incidence of PICM in patients with normal LVEF and AVB is alarmingly high. PICM in patients with a previously normal LVEF is associated with unfavorable outcomes.
Table 1 Characteristics Cohort without PICM (152) n (%) Cohort with PICM (51) n(%) p Age mean ± SD 74.6 ± 10.5 71 ± 13 0.04 Gender (male) 80 (52.6) 29 (56.9) 0.6 Pacing modeDDDVDDVVI 108 (71.1) 38 (25) 6 (3.9) 34 (66.7) 15 (29.4) 2(3.9) 0.83 Hypertension 112 (73.7) 36 (70.6) 0.67 PVD 16 (10.5) 5 (8.9) 0.88 CAD 36 (23.7) 19 (37.3) 0.01 CVA / TIA 17 (11.2) 7 (13.7) 0.63 Atrial fibrillation / flutter 18 (11.8) 9 (17.6) 0.29 COPD 15 (9.9) 2 (3.9) 0.25 Diabetes Mellitus 56 (36.8) 27 (52.9) 0.04 Chronic Kidney Disease 27 (17.9) 14 (27.5) 0.14 Statins 65 (43) 30(60) 0.04 ACE inhibitors / ARBs 52 (34.4) 18 (36) 0.84 Beta Blockers 42 (28) 10 (20) 0.26 LVEDD mm 45.13 ± 5.53 48.46 ± 5.97 &lt;0.001 LVESD mm 25.68 ± 5.28 27.72 ± 4.67 0.02 Baseline characteristics
Abstract Figure. HF and Mortality outcomes
P1163Correction of septal flash excursion with his bundle pacing
Authors: Pujol-Lopez M , San Antonio R , Jimenez Arjona R , Guasch E , Doltra A , Sitges M , Roca-Luque I , Trotta O , Quinto L , Arbelo E , Alarcon F , Garre P , Mont L , Tolosana J M 
Published: June 2020

Abstract

Funding Acknowledgements
Grant from the Catalan Society of Cardiology

Background
His bundle pacing (HBP) directly stimulates the conduction system and could therefore correct asynchrony and evolve as a more physiological pacing approach. Septal flash (SF) is a fast contraction and relaxation of the septum occurring during the isovolumetric contraction period. It is a specific marker of cardiac dyssynchrony.

Purpose
Evaluate whether HBP corrects SF in patients with an indication for CRT or RV pacing.

Methods
A cohort of 20 consecutive patients undergoing HBP at our center was analyzed. HBP indications were: Group A (n = 3): left bundle branch block (LBBB) and left ventricular (LV) dysfunction (LV ejection fraction [LVEF] &lt; 35%); Group B (n = 14): LV dysfunction (LVEF &lt; 50%) and atrio-ventricular block requiring permanent pacing; Group C (ablate&pace, n = 3): atrio-ventricular node ablation due to rapid atrial fibrillation.
Patients in groups B and C had a RV backup lead implanted, in line with current recommendations. The presence of SF was analyzed in 2D-echocardiography at 15 days post-implant. SF excursion was quantified using M-mode in parasternal short and long axis views as the highest amplitude of the early inward motion. Baseline SF excursion was determined during intrinsic rhythm (group A) or RV pacing (groups B and C). For each patient, the pair of measurements (baseline, HBP) in the axis with the highest baseline SF was selected.

Results
Mean LVEFs were 21 ± 8%, 32 ± 6%, and 41 ± 18% for groups A, B and C, respectively. HBP shortened QRS duration by 42 ± 15 ms and 45 ± 23 ms in groups A (Baseline QRS - HBP QRS) and B + C (RV pacing QRS - HBP QRS), respectively. At baseline, all patients except 1 had SF (Fig. 1A). The mean SF excursion was 4.3 ± 1.9 mm, with SF excursion being larger in group A than in the RV-paced groups (6.3 ± 1.5 mm vs. 3.9 ± 1.8 mm for groups A and B + C, respectively, p = 0.04). HBP abolished SF in 3 patients (15%) and, on average, decreased SF excursion by 2.3 mm (95% CI 1.3-3.2), irrespective of pacing indication (Fig. 1B). The degree of SF excursion reduction after HBP significantly correlated with QRS shortening (r = 0.53, p = 0.024) (Fig 1C).

Conclusions
In conclusion, we show that HBP results in acute correction or decrease of SF, thereby improving LBBB- or RV-induced mechanical dyssynchrony.
Abstract Figure. Septal Flash and His pacing
917Appropriate shocks in WCD patients - Results from the Austrian WCD registry
Authors: Rohrer U , Manninger M , Odeneg T , Zweiker D , Moertl D , Keller H , Dirninger A , Stix G , Alber H , Steinwender C , Binder R , Stuehlinger M , Ebner C , Zirlik A , Scherr D 
Published: June 2020

Abstract

Background
The wearable cardioverter-defibrillator (WCD) is a temporary treatment option for patients at high risk for sudden cardiac death (SCD) and/or for patients in whom implantation of a cardioverter defibrillator (ICD) is temporarily not possible.

Purpose
To investigate incidence and predictors of appropriate WCD shocks.

Methods
We performed a retrospective analysis of all patients with appropriate shocks delivered by a WCD in the cohort of the Austrian WCD registry between 2010 and 2018. Within this dataset, we identified predictors within the baseline characteristics, the indication for the WCD and preceding alarms automatically recorded by the WCD.

Results: Baseline
Within 879 registered in the Austrian WCD registry, 31 patients (3,5%) received appropriate WCD shocks due to ventricular tachycardia (VT) or ventricular fibrillation (VF). Compared to the total cohort, shocked patients were elder (mean age 67 ± 14 vs. 60 ± 14 years, p = 0,001) and the percentage of female patients was lower (11% vs. 21%, p = 0,262). The mean baseline LVEF at prescription was 33 ± 15% in the population with appropriate shocks compared to 32 ± 14% in the all-over cohort (p = ns).
In the Austrian WCD population, 378/879 patients had a WCD due to secondary prevention. Within this cohort 5,6% (21/378) had shocks for VT/VF again, compared to 10/501 (2%) shocked patients in the primary prevention cohort. 31/879 (3.5%) patients received 57 appropriate shocks, the per patient shock rate was 2 [1;5]. These shocks were induced by 25 ventricular tachycardia and 26 times ventricular fibrillation.
The octagenarians with 11% (7/34) shocked patients, showed a significant higher likelihood to receive shocks (p = 0,008) as well as the cohort of secondary preventive prescribed WCD-patients (p = 0,007). There were more shocks in patients, when prescribed with a WCD due to ICD associated infections (p = 0,001), when used as a bridge to ICD (p = 0,042) and in patients with ongoing risk stratification (p = 0,009).
Looking through the automatically recorded alarms preceding a WCD shock, shocked patients experienced significantly more often non sustained VTs (p &lt; 0,0005) and sustained VTs that were haemodynamically tolerated and did not require a treatment (p &lt; 0,0005).

Conclusion
The WCD is effective in preventing SCD and an important risk stratification tool. We identified advanced age, patients with either already confirmed indication for ICD implantation (either temporary contraindication for implantation or temporary explantation) or risk stratification of an unclear cardiomyopathy, the cohort of secondary prevention and preceding nsVTs and stable VTs as predictors for appropriate WCD therapies.
P1402Isolation of pulmonary veins with duty-cycled circular multi-polar catheter: randomized controlled clinical trial
Authors: De Sousa J , Cortez-Dias N , Carpinteiro L , Silva G , Nunes Ferreira A , Silverio Antonio P , Bernardes A , Barreiros C , Ribeiro J , Sobral S , Pinto F 
Published: June 2020

Abstract

Introduction
Pulmonary vein isolation (PVI) is the central element in the ablation of atrial fibrillation (AF), and can be obtained with different ablation modalities. The duty-cycled circular multi-pole catheter PVAC® (Medtronic) allows linear application of radiofrequency energy, with the production of circumferential lesions. Conceptually, it can make ablation simpler and faster in patients with favorable anatomy.

Objectives
To evaluate the safety and efficacy of ablation with a PVAC® catheter and to compare it with the conventional technique point-by-point (PbP) with irrigated catheter.

Methods
Clinical trial with single-blinded patients with AF refractory to antiarrhythmic therapy, randomized (1: 1) for ablation with PVAC® or PbP. The ablation strategy consisted of PVI, complemented with ablation of the cavo-tricuspid isthmus in patients with history of concomitant flutter. Monitoring was performed with a 7-day event loop recorder at 3, 6 and 12 months and annually from the 2nd year. Success was defined by AF-free survival or any maintained supraventricular tachycardia (duration &gt; 30seconds).

Results
354 patients (67.5% males, 58 ± 12 years, PbP: 175, PVAC: 179) were included, of which 59.1% had paroxysmal, 26.2% short-standing persistent and 14.7% had long-standing persistent AF. Baseline characteristics were similar between groups. Among patients treated with PVAC, 93.1% of the pulmonary veins were isolated (620/666), similar to the 98.3% immediate success of the PbP group (697/709). Although the complication rate was similar in both groups (PVAC: 4.9% vs. PbP: 7.8%; P = NS), the risk of hemopericardium was lower with PVAC (0% vs. 4.6%; P = 0.013). Two patients treated with PVAC developed stroke (1.13% vs. 0%; P = NS). The duration of the procedure was lower among the patients treated with PVAC [136 (100-180) vs. 230 (188-270) min; P &lt;0.001], with no difference in fluoroscopy time [24.4 (14.5-36.8) vs. 27.1 (17.0-45.0) min]. The success rate after 1st ablation at 36 months was 68%, with no differences between groups. The success rate after multiple ablations increased to 85.8%, with no differences between groups.

Conclusion
The multipolar PVAC catheter can represent an added value in AF ablation, making the procedure simpler and faster, ensuring similar efficacy to the conventional technique and with a lower risk of cardiac tamponade. The present trial suggests the need for clinically manifested stroke risk surveillance, which may be increased with this technique.
Abstract Figure.
P1469Micra pacemaker implant at septal site induces a smaller increase on qrs duration than traditional pacemaker: a single center experience
Authors: Zucchelli G , Parollo M , Barletta V , Di Cori A , Della Tommasina V , Mazzocchetti L , Viani S , Giannotti Santoro M , De Lucia R , Segreti L , Cellamaro T , Paperini L , Soldati E , Bongiorni M G 
Published: June 2020

Abstract

BACKGROUND
Leadless pacemakers have been introduced into the clinical practice as a breakthrough technology that could tackle most of the major sources of complication of traditional pacemakers (PM). The excellent safety profile and optimal electrical performance of Micra have been already largely described, nevertheless the impact on QRS duration has not been investigated so far. We aimed to compare changes in QRS duration after septal Micra implant in comparison to patients who received transvenous right ventricular leads in the same position.

METHODS
We enrolled all patients who underwent Micra implantation (group 1) at our Center from April 2017 to March 2019. A septal placement was attempted in all cases. Duration of spontaneous and paced QRS and their difference (delta QRS) were measured using a polygraph. To provide a comparison group, we analyzed the QRS duration in a matched group of patients (group 2) who received a traditional single chamber pacing system with a transvenously implanted lead at septal position in the same period. Confounding variables that were used to provide the control group were age, sex, left ventricle ejection fraction, and rhythm at implant. High pacing threshold was defined as ≥1.0 V at pulse duration of 0.24 ms.

RESULTS
Twenty-eight consecutive patients (mean age 78 ± 3 years; 71.43% males) who underwent successful Micra implant were enrolled. A septal position was achieved in all cases with a single device delivery in 17/28 patients (60.7%). Mean pacing threshold at implant was 0.56 ± 0.34V/0.24 ms with only 3/28 patients (10.7%) presenting a high pacing threshold. No significant differences in demographic, clinical characteristics and ventricular pacing site were observed between groups. QRS duration was slightly longer in group 1 compared to group 2 before implant (median 123 ms (IQR 104-146.5 ms) vs median 116 ms (IQR 90-125 ms); p = 0.09). Nevertheless, there was a significantly lower delta QRS after implant in Micra compared to the traditional pacing group (15.82 ± 31.77 ms vs 35.82 ± 22.13 ms, p = 0.008).

CONCLUSION
Right ventricular stimulation induces ventricular dyssynchrony, which is correlated with the amount of QRS enlargement after pacing. Micra implant, in a non-apical position, produces significantly smaller changes on the QRS duration in comparison with transvenous lead implanted at the same site, although larger studies are necessary to confirm these results.
P1134Cardiac pacemakers and transient electromagnetic interferences during radiotherapy courses: a multicentre, real-time, in-vitro evaluation
Authors: Di Girolamo E , Appignani M , Marini M , De Filippo P , Leidi C , Di Girolamo F , Delana A , Barbareschi A , Andreoli S , Genovesi D , Falco M D 
Published: June 2020

Abstract

Funding Acknowledgements
None

Background
The effects of high dose oncologic radiotherapy (RT) on cardiac pacemakers (PMs), at even less than 6 MV power, are unpredictable, depending on multiple factors. Normal PM function may be impaired during direct exposure, due to electromagnetic interferences (EMIs). Potentially life-threatening malfunctions may occur, expecially in PM-dependent patients, and both manufacturers and guidelines discourage direct exposure.

Purpose
To evaluate transient EMI-related PM malfunctions during direct exposure to doses up to 10 Gy during radiotherapy course, 17 wireless-telemetry-enabled PMs with sufficient residual battery charge for the purpose of the study (at least 4 months to elective replacement indicator, E.R.I.) were evaluated in three different centres.

Methods
All PMs underwent baseline interrogation. Single chamber devices were programmed in the VVI/40 mode while dual or triple chamber devices were programmed in the DDD/40 mode. To avoid the "run-away" phenomenon during exposure rate-adaptive function was disabled. A centering computed tomography was performed to build the corresponding treatment plan and the PMs were blinded randomized to receive either 2, 5 or 10 Gy exposure by a 6 MV linear accelerator in a homemade water phantom (600 Um/min). The effective dose received by the PMs was randomly assessed by an in-vivo dosimetry. During RT course, the devices were observed in a real-time session using manufacturer specific equipment, and PM function (pacing and sensing, programmed parameters) was recorder by a video camera in the bunker throughout the entire radiation exposure.

Results
During RT course, 13 PMs (76.5%) recorded not clinically relevant minor transient EMIs, and no atrial and/or ventricular oversensing nor base-rate-pacing inhibition were observed. Only 4 PMs (23.5%) reported neither transient malfunction nor minor EMIs, withstanding direct radiation exposure. Transient EMI-related malfunctions were observed regardless of either 2, 5 or 10 Gy exposure.

Conclusions
Minor, not clinically relevant EMI-related interferences were observed in most of the PMs during direct exposure. Nevertheless, to avoid potentially life-threatening PM malfunctions, magnet application on the PM pocket site or reprogramming are still suggested in PM-dependent (high risk) patients ongoing even low energy RT exposure.
P1419Persistent atrial fibrillation terminates during ablation more often using dispersion mapping than with fractionated electrogram mapping
Authors: Zaman J , Agarwal S 
Published: June 2020

Abstract

Introduction
Persistent AF termination rates have increased since the advent of AF driver mapping, with a recent meta-analysis (Baykaner Circ AE 2018) of over 3200 patients showing improved 12 month freedom from AF/AT. However, recent randomised clinical trials have cast doubt on the efficacy of complex fractionated atrial electrograms (CFAE) based mapping strategies. We
set out to study a consecutive single centre series pre-and post- use of spatio-temporal dispersion (STD) to identify termination rates between the two approaches.

Methods
We recruited consecutive patients over 18 months at a single high volume tertiary centre undergoing first redo ablation for persistent AF. Patients were all
mapped using Pentarray to mark areas of substrate using the spatio-temporal dispersion (STD) method (Seitz JACC 2017).
Ablation was performed by a single operator using catheters to standardise equipment and workflow, to enable true
comparison of mapping and ablation results in a consecutive series.

Results
In total 38 patients were studied at redo ablation for persistent AF (age 69, 87% male, LA diameter 4.5cm). Termination of persistent
AF to SR (30%) or AT (70%) was obtained in 30/38 (79%) of the group with STD based substrate ablation vs. 1/38 (3%) in patients mapped
with CFAE targeting using identical equipment and operator (p &lt; 0.001). Procedure time was no different between STD and CFAE based
approaches (263 vs. 248 mins, p = ns). Figure shows STD patterns (red arrows) on Pentarray in a 67 year old man anterior to left inferior
pulmonary vein (A), where ablation terminated AF to sinus rhythm. At 12 month follow up, 30/38 (79%) patients were in sinus rhythm with no AF detected on ECG or continuous monitoring.

Conclusions
In this single centre series of persistent AF ablations, the use of STD mapping increased rates of termination compared to a fractionation based mapping strategy alone, without increasing overall procedure time. Clinical outcome data suggest this translates into better 12 month clinical outcomes, and motivate prospective randomised trials to definitively study this technique.
Abstract Figure.