bluuebunny/crossref_metadata_2025_split huggingface dataset:
The strong bridge between African librarians and international partnerships
Authors: Musoke Maria G.N. 
Published: December 2020

AbstractThe paper highlights the experience of working with Shane Godbolt when she was a practising Medical librarian, her mentorship to younger librarians/information professionals, her personal and professional support to African librarians and the role she played as the Director of Partnerships in Health Information (Phi). These activities led to successful collaboration between Phi and African librarians. Indeed Shane widened the networks and opened up opportunities for many.
Severe glomerular C3 deposition indicates severe renal lesions and a poor prognosis in patients with immunoglobulin A nephropathy
Authors: Wu Jianliang , Hu Zhizhi , Wang Yuxi , Hu Danni , Yang Qian , Li Yueqiang , Dai Wei , Zhu Fengming , Yang Juan , Wang Meng , Zhu Han , Liu Liu , He Xiaofeng , Han Min , Yao Ying , Pei Guangchang , Zeng Rui , Xu Gang 
Published: December 2020

AimsGlomerular complement 3 (C3) deposition is often observed in renal biopsies of patients with IgA nephropathy (IgAN); however, the relationship between the intensity of C3 deposition and the long‐term prognosis of IgAN has rarely been reported. In this retrospective study, we aimed to evaluate the prognostic value of glomerular C3 deposition for IgAN progression.Methods and resultsFrom June 2009 to June 2010, a total of 136 adult patients with IgAN were enrolled in the study. According to the intensity of glomerular C3 deposition, patients were divided into a glomerular C3high group (34 patients) and a glomerular C3low group (102 patients). The levels of clinical parameters, glomerular immune complexes, histopathological features, and serum cytokines of the two groups were compared. On the basis of an average of 105 months of follow‐up, the predictive value of glomerular C3 deposition for IgAN progression was also investigated. Patients in the C3high group had more severe glomerular IgA, IgG, IgM, and complement factor H deposition, a higher percentage of mesangial hypercellularity (M1), and higher levels of segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T2), and crescents (C2) than those in the C3low group. Renal biopsies in the C3high group showed higher densities of interstitial inflammatory cells and higher levels of serum interferon‐γ than those in the C3low group. Multivariate Cox regression analysis revealed that a higher intensity of glomerular C3 deposition remained as an independent predictor of serum creatinine doubling and end‐stage renal disease.ConclusionsA high intensity of glomerular C3 deposition is associated with the severity of renal lesions, and predicts long‐term poor renal survival for IgAN patients.
The effect of protease inhibitor‐based dual antiretroviral regimens on CD4/CD8 ratio during the first year of therapy in ART‐naïve patients with HIV‐infection
Authors: Figueroa MI , Camiro‐Zuñiga A , Belaunzaran‐Zamudio PF , Sierra Madero J , Andrade Villanueva J , Arribas JR , Lama JR , Cecchini DM , Lopardo G , Crabtree‐Ramírez B , Gun A , Patterson P , Fink VI , Sued OG , Cahn P 
Published: December 2020

ObjectivesTo assess the effect of protease inhibitor (PI)‐based dual therapy on CD4/CD8 ratio during the first year of therapy in antiretroviral therapy (ART)‐naïve patients using data from randomized controlled clinical trials.MethodsWe pooled data from the GARDEL and ANDES studies, both randomized controlled clinical trials that recruited ART‐naïve people living with HIV and randomly assigned them to receive PI‐based dual therapy (DT) or triple therapy (TT) aiming to compare viral efficacy. We compared median CD4/CD8 ratios and the proportion of patients with CD4/CD8 ratio > 1 at 48 weeks after ART initiation in both treatment arms using the Mann–Whitney U‐test and the χ2 test. We performed subgroup analysis for patients > 50 years old, with baseline CD4 counts ≤ 200 cells/μL, viral load > 100 000 HIV RNA copies/mL, and ritonavir‐boosted lopinavir‐based therapy.ResultsWe analysed data from 571 patients: 292 on DT and 279 on TT. No differences were observed in CD4/CD8 ratio (0.632 vs. 0.617, P = 0.729) or in the proportion of patients with CD4/CD8 ratio > 1 (17.9% vs. 19.3%, P = 0.678) 48 weeks after ART initiation. Subgroup analysis showed no further differences.ConclusionThe impact of PI‐based DT regimens on the CD4/CD8 ratio during the first year of treatment for ART‐naïve patients is similar to that of TT.
Clinical and onychoscopic characteristics of subungual glomus tumor: a cross‐sectional study
Authors: Grover Chander , Jayasree Puravoor , Kaliyadan Feroze 
Published: December 2020

AbstractBackgroundSubungual glomus tumor is a relatively uncommon entity with varied clinical presentations which may lead to diagnostic delays. Onychoscopy can be used as an evaluation tool in routine evaluation of glomus tumors.Objectives and methodsWith an aim to characterize the onychoscopic features of subungual glomus tumors, we analyzed 15 cases presenting over 3 years, in this observational study. The clinical, onychoscopic, radiological, and operative findings in these patients were evaluated and correlated depending on the location and extent of the lesions.ResultsAll 15 patients (11 female and 4 male) had pain as the presenting symptom and fulfilled the classic triad of paroxysmal pain, cold sensitivity, and positive Love's pin test. Clinical nail plate findings included onycholysis, onychorrhexis with distal splitting, and onychoschizia, while nail bed and matrix findings included localized erythematous and bluish patches, longitudinal erythema, and altered lunula. Onychoscopy corroborated the clinical findings and revealed a more extensive area of involvement in five cases. Definitive onychoscopy findings included a localized structureless erythema interspersed with bluish and patchy whitish areas (five cases of nail bed and six nail matrix tumors) and a “candy‐cane appearance” (six cases, all large and lobulated nail matrix tumors). MRI reported the tumor in 13 cases, while two nail matrix tumors were missed. Transungual excision revealed tumors larger in size than predicted by MRI. The presence of candy‐cane appearance was consistent with lobulated matrix tumors.ConclusionOnychoscopy improves the intraoperative detection of location and extent of subungual glomus tumors. Nail bed and nail matrix glomus tumors can have distinctive onychoscopic features that may help in better surgical planning.
From Geneva to San José: The ILO standards and the Inter‐American System for the protection of human rights
Authors: DUHAIME Bernard , DÉCOSTE Éloïse 
Published: December 2020

AbstractThis article analyses how the Inter‐American System for the protection of human rights has used ILO standards as a reference on matters relating to freedom of association and the rights of indigenous peoples. Having established the limits to their use, the authors also analyse how these standards have influenced recent Inter‐American jurisprudence in relation to certain economic, social and cultural rights. They argue that such cross‐referencing is both desirable and useful, since it allows the Inter‐American bodies to base their arguments on the interpretation of specialized authorities, thereby reinforcing the credibility, normative legitimacy and universality of their decisions.
Examining the association between evidence‐based practice and the nurse‐patient therapeutic relationship in mental health units: A cross‐sectional study
Authors: Moreno‐Poyato Antonio R. , Casanova‐Garrigos Georgina , Roldán‐Merino Juan F. , Rodríguez‐Nogueira Óscar ,   MiRTCIME.CAT working group
Published: December 2020

AbstractAimsTo examine the relationship between the dimensions of evidence‐based practice and the therapeutic relationship and to predict the quality of the therapeutic relationship from these dimensions among nurses working in mental health units.DesignA cross‐sectional design.MethodsData were collected between February–April 2018 via an online form completed by nurses working at 18 mental health units. Multiple linear regressions were used to examine the relationship between the dimensions of evidence‐based practice and therapeutic relationship. Questionnaires were completed by 198 nurses.ResultsHigher levels of evidence‐based practice were a significant predictor of a higher‐quality therapeutic relationship (β: 2.276; 95% CI: 1.30–3.25). The evidence‐based practice factor which most influenced an improved therapeutic relationship was the nurses’ attitude (β: 2.047; 95% CI: 0.88–3.21). The therapeutic relationship dimension which was most conditioned by evidence‐based practice dimensions was agreement on tasks, which was most favourable with a better attitude (β: 0.625; 95% CI: 0.09–1.16) and greater knowledge and skills for evidence‐based practice (β: 0.500; 95% CI: 0.08–0.93).ConclusionIn mental health settings, the therapeutic nurse–patient relationship is positively enhanced by evidenced‐based practice and the nurse's level of experience, with a great influence on shared decision‐making.ImpactThis research sought to examine the relationship between the evidence‐based practice and the therapeutic relationship in mental health nursing. This study demonstrates that an improved attitude and knowledge of evidence‐based practices of mental health nurses increases shared decision‐making with patients, which is a basic requirement for person‐centred care. Because the therapeutic relationship is considered the backbone of nursing practice in mental health units, this research will have an impact on both mental health nurses and mental health unit managers.
Weight and gender bias in observer perceptions of organizational leadership: Effects of perceived leader prototypicality and unit performance
Authors: Merritt Stephanie M. , Lynch Ellen E. 
Published: December 2020

AbstractDespite the importance of organizational leaders, few studies have examined whether leaders are subject to stigma and biases based on amount of body fat. Specifically, we examine the extent to which external observers exhibit weight‐based biases against organizational leaders based on types of information that commonly appear in the media (e.g., a portrait and description of unit performance). Based on implicit leadership theory, we examine perceptions of leader prototypicality and ratings of leader effectiveness, as predicted by the interacting effects of leader body fat, leader gender, and the performance of the leader's work unit. Our sample consisted of 437 U.S. adults, recruited through Mturk, who evaluated fictitious leaders. Results suggested that leaders were, indeed, subject to statistically significant weight penalties in perceived leader effectiveness, which operated indirectly via decreased perceptions of leader prototypicality. These weight penalties were significantly increased for both man and woman leaders when unit performance was poor. In terms of credit/blame for unit performance, woman leaders with higher body fat received significantly more blame for unit failure, and less credit for unit success, than their counterparts with lower body fat. Overall, results suggest that external observers seem to exhibit weight‐based biases against leaders, particularly when other information can be used to justify negative evaluations.
Combining teacher‐Led and technology‐assisted instruction to improve phoneme blending to read words for elementary students with disabilities
Authors: Coleman Mari Beth , Fowler Kristen , Parater Alexandra Lee , Riley Marie Jackson , Park Yujeong , Moore Tara C. 
Published: December 2020

AbstractTechnology‐assisted instruction has potential for helping students improve their reading skills. In the current studies, PowerPoint software was used to supplement teacher‐led reading instruction for elementary‐aged students with disabilities who struggled with phoneme blending to read words. The effectiveness of the intervention was assessed using two multiple probe design studies across sets of words based on an onset‐rime (word family) strategy. In Study 1, teacher‐led instruction was paired with technology‐assisted instruction for all intervention sessions for three students in first and second grade. In Study 2, teacher‐led instruction occurred between baseline and technology‐assisted intervention sessions for three students in third and fourth grade. During the initial instruction sessions, participants recorded their own voices onto PowerPoint slides so that their technology‐assisted instruction included self‐modelling. Results of both studies indicated that technology‐assisted instruction can be effective for helping students learn how to blend phonemes to read words; however, performance varied and there were limitations in each study that should be addressed in future research. Relevant implications for classroom instruction are emphasized.
Association between real‐world home blood pressure measurement patterns and blood pressure variability among older individuals with hypertension: A community‐based blood pressure variability study
Authors: Lin Jia‐You , Kuo Kuan‐Liang , Kuo Yi‐Hsin , Wu Kun‐Pin , Chu Kuo‐Chung , Jiang Yan‐Chen , Chuang Yi‐Fang , Cheng Hao‐Min 
Published: December 2020

AbstractHome blood pressure (BP) monitoring is a useful tool for hypertension management. BP variability (BPV) has been associated with an increased risk of cardiovascular events. However, little is known about the correlation between BPV and different measurement patterns of long‐term home BP monitoring. This longitudinal cohort study aimed to assess the associations between dynamic BP measurement patterns and BPV. A total of 1128 participants (mean age, 77.4 ± 9.3 years; male, 51%) with 23 269 behavior measuring units were included. We used sliding window sampling to classify the home BP data with a regular 6‐month interval into units in a sliding manner until the data are not continuous. Three measurement patterns (stable frequent [SF], stable infrequent [SI], and unstable [US]) were assessed based on the home BP data obtained within the first 3 months of the study, and the data in the subsequent 3 months were used to assess the BPV of that unit. We used linear mixed‐effects model to assess the association between BP measurement patterns and BPV with adjustment for possible confounding factors including average BP. Average real variability and coefficient variability were used as measures of the BPV. No significant differences were observed in average BP between the SF, SI, and US patterns. However, BPV in the SF group was significantly lower than that in the US and SI groups (all p‐values < .05). The BPV in SI and US groups was not significantly different. A stable and frequent BP measuring pattern was independently associated with a lower BPV.
Long non‐coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up‐regulation by binding to microRNA‐21
Authors: Lin Liqiang , Liu Xiaoli , Lv Baotao 
Published: December 2020

AbstractLong non‐coding RNAs (lncRNAs) have been highlighted as attractive markers for diagnosis and prognosis as well as new therapeutic targets in multiple cancers, including nasopharyngeal carcinoma (NPC). Here, we attempted to investigate the underlying regulatory role of the lncRNA maternally expressed gene 3 (MEG3) in NPC development. As determined by RT‐qPCR, MEG3 expression was down‐regulated in NPC cells. Online RNA crosstalk analysis predicted the binding of miR‐21 to MEG3 and PTEN, respectively. MEG3 was validated to bind to miR‐21 while PTEN was identified as a target of miR‐21 by dual‐luciferase reporter gene assay. Exogenous transfection was done to change the levels of MEG3, miR‐21 and PTEN in HK‐1 cells to investigate their effects on the autophagy and apoptosis of NPC cells. The results suggested that MEG3 overexpression in HK‐1 cells up‐regulated PTEN and down‐regulated miR‐21, by which MEG3 further inhibited autophagy and apoptosis ability of NPC cells. The tumour formation ability was tested after injecting the HK‐1 cells into nude, mice and tumour growth was monitored. Consistently, MEG3 overexpression inhibited the tumour formation in vivo. Collectively, MEG3 promotes the autophagy and apoptosis of NPC cells via enhancing PTEN expression by binding to miR‐21.
Sustained expression of MCP‐1 induced low wall shear stress loading in conjunction with turbulent flow on endothelial cells of intracranial aneurysm
Authors: Chu Cheng , Xu Gang , Li Xiaocong , Duan Zuowei , Tao Lihong , Cai Hongxia , Yang Ming , Zhang Xinjiang , Chen Bin , Zheng Yanyu , Shi Hongcan , Li Xiaoyu 
Published: December 2020

AbstractShear stress was reported to regulate the expression of AC007362, but its underlying mechanisms remain to be explored. In this study, to isolate endothelial cells of blood vessels, unruptured and ruptured intracranial aneurysm (IA) tissues were collected from IA patients. Subsequently, quantitative real‐time PCR (qRT‐PCR), Western blot and luciferase assay were performed to investigate the relationships between AC007362, miRNAs‐493 and monocyte chemoattractant protein‐1 (MCP‐1) in human umbilical vein endothelial cells (HUVECs) exposed to shear stress. Reduced representation bisulphite sequencing (RRBS) was performed to assess the level of DNA methylation in AC007362 promoter. Accordingly, AC007362 and MCP‐1 were significantly up‐regulated while miR‐493 was significantly down‐regulated in HUVECs exposed to shear stress. AC007362 could suppress the miR‐493 expression and elevate the MCP‐1 expression, and miR‐493 was shown to respectively target AC007362 and MCP‐1. Moreover, shear stress in HUVECs led to the down‐regulated DNA methyltransferase 1 (DNMT1), as well as the decreased DNA methylation level of AC007362 promoter. Similar results were also observed in ruptured IA tissues when compared with unruptured IA tissues. In conclusion, this study presented a deep insight into the operation of the regulatory network of AC007362, miR‐493 and MCP‐1 upon shear stress. Under shear stress, the expression of AC007362 was enhanced by the inhibited promoter DNA methylation, while the expression of MCP‐1 was enhanced by sponging the expression of miR‐493.
Serum proteomic analysis of novel predictive serum proteins for neurological prognosis following cardiac arrest
Authors: Gu Shuang‐shuang , Li Jin , Jiang Min , Zhou Yi , Yang Bing , Xie Kehui , Jiang Yun‐fei , Jiang Xin‐rui , He Fei , Wang Jun 
Published: December 2020

AbstractEarly prognostication of neurological outcome in comatose patients after cardiac arrest (CA) is vital for clinicians when assessing the survival time of sufferers and formulating appropriate treatment strategies to avoid the withdrawal of life‐sustaining treatment (WLST) from patients. However, there is still a lack of sensitive and specific serum biomarkers for early and accurate identification of these patients. Using an isobaric tag for relative and absolute quantitation (iTRAQ)‐based proteomic approach, we discovered 55 differentially expressed proteins, with 39 up‐regulated secreted serum proteins and 16 down‐regulated secreted serum proteins between three comatose CA survivors with good versus poor neurological recovery. Then, four proteins were selected and were validated via an enzyme‐linked immunosorbent assay (ELISA) approach in a larger‐scale sample containing 32 good neurological outcome patients and 46 poor neurological outcome patients, and it was confirmed that serum angiotensinogen (AGT) and alpha‐1‐antitrypsin (SERPINA1) were associated with neurological function and prognosis in CA survivors. A prognostic risk score was developed and calculated using a linear and logistic regression model based on a combination of AGT, SERPINA1 and neuron‐specific enolase (NSE) with an area under the curve of 0.865 (P < .001), and the prognostic risk score was positively correlated with the CPC value (R = 0.708, P < .001). We propose that the results of the risk score assessment not only reveal changes in biomarkers during neurological recovery but also assist in enhancing current therapeutic strategies for comatose CA survivors.
Hepatic stellate cells specific liposomes with the Toll‐like receptor 4 shRNA attenuates liver fibrosis
Authors: Zhang Yuwei , Li Yang , Mu Tong , Tong Nanwei , Cheng Ping 
Published: December 2020

AbstractThe hepatic stellate cells (HSCs) play a significant role in the onset of liver fibrosis, which can be treated by the inhibition and reversal of HSC activation. The RNA interference‐mediated TLR4 gene silencing might be a potential therapeutic approach for liver fibrosis. The crucial challenge in this method is the absence of an efficient delivery system for the RNAi introduction in the target cells. HSCs have an enhanced capacity of vitamin A intake as they contain retinoic acid receptors (RARs). In the current study, we developed cationic liposomes modified with vitamin A to improve the specificity of delivery vehicles for HSCs. The outcome of this study revealed that the VitA‐coupled cationic liposomes delivered the TLR4 shRNA to aHSCs more efficiently, as compared to the uncoupled cationic liposomes, both in the in vitro and in vivo conditions. Besides, as evident from the outcome of this study, the TLR4 gene silencing inhibited the HSCs activation and attenuated the liver fibrosis via the NF‐κB transcriptional inactivation, pro‐inflammatory cytokines secretion and reactive oxygen species (ROS) synthesis. Thus, the VitA‐coupled liposomes encapsulated with the TLR4‐shRNA might prove as an efficient therapeutic agent for liver fibrosis.
Incidence of occupational contact dermatitis in healthcare workers: a systematic review
Authors: Larese Filon F. , Pesce M. , Paulo M.S. , Loney T. , Modenese A. , John S.M. , Kezic S. , Macan J. 
Published: December 2020

AbstractHealthcare workers (HCWs) can be considered at an increased risk of developing occupational contact dermatitis (OCD) due to repetitive hand washing with soaps and disinfectants and extended use of gloves for many hours during the day. The aim of this study was to summarize the incidence of OCD in HCWs. We searched the databases PubMed/MEDLINE (1980‐present), EMBASE (1980‐present) and Cochrane Library (1992‐present) through May 2020 using the search term ‘incidence of contact dermatitis in HCWs' according to Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines. Overall, 16 studies (six cohorts; 10 register‐based) with follow‐up periods between 1987 and 2013 fulfilled the inclusion criteria. The incidence of OCD reported in studies using registers of occupational diseases ranged from 0.6 to 6.7 per 10 000 person‐years. The cohort studies reported incidence from 15.9 to 780.0 per 10 000 person‐years; the incidence was higher in studies which included apprentice nurses. A higher incidence was also observed amongst dental practitioners, particularly dental technicians and nurses, compared to other HCWs. Studies reporting incidence data are very scarce and results differed by study design, type of contact dermatitis and investigated HCWs. Our study highlighted the dearth of high‐quality data on the incidence of OCD and the possible underestimation of disease burden. Prospective cohort studies with harmonized designs, especially exposure assessment and outcome ascertainment, are required to provide more accurate, valid and recent estimates of the incidence of OCD. A high incidence amongst specific occupational groups suggests the need to undertake intervention studies with a focus on prevention, particularly during pandemics such as COVID‐19.