bluuebunny/crossref_metadata_2025_split huggingface dataset:
How BIM systems affect maintaining IBS building
Authors: Ismail Zul-Atfi 
Published: March 2020

Purpose
The purpose of this paper is to discuss the system approaches and their application for managing IBS building in the context of Malaysian maintenance practice. Currently, the maintenance management method has affected the efficiency of the complex and high-rise industrialised building system (IBS) building maintenance management in Malaysia. Many issues such as poor service delivery, limited budgets, less competent staff and defect repetition emerged because of the usage of conventional method applications (paper-based form). The data revealed that the practice of maintenance management for complex and high-rise IBS buildings needs to be digitalised.

Design/methodology/approach
This qualitative research was carried out by conducting literature review and semi-structured interviews. Eight major maintenance organisations were selected based on a conventional method of practice in managing maintenance for complex and high-rise IBS buildings. The computerised system was developed using a data flow diagram and coding. Subsequently, the prototype system was tested.

Findings
By having this prototype system, the defect diagnosis and decision-making process become easier, faster and cost-effective in facilitating the maintenance assessment, defect diagnosis and control in relation to IBS building structure components.

Originality/value
In conclusion, the prototype system may improve the effectiveness of maintenance management practices for IBS building structure components in reducing defect design risks such as design calculation error to provide high-quality IBS building structure components for a safe and healthy environment.
Post-occupancy evaluation of University of Uyo buildings
Authors: Ikediashi Dubem , Udo Godfrey , Ofoegbu Maureen 
Published: March 2020

PurposeThis study aims to evaluate the performance of buildings in the University of Uyo using the post-occupancy evaluation (POE) technique.Design/methodology/approachA quantitative questionnaire survey is adopted in which 333 copies of a validated questionnaire are administered to academic, administrative and maintenance staff and some students who occupy four buildings used for the survey. However, 124 valid responses are received giving a response rate of 37per cent. Data collected are analysed using descriptive and inferential statistical tools while the Kruskal Wallis chi-square (χ2) test is used to analyse hypotheses postulated for the study.FindingsFindings reveal that the General Administration (GA) building has high ratings in five technical performance criteria of ambient level of sound in offices, the integrity of materials used for walls, and correctness of stair risers, threads in the building quality of lighting and quantity of lighting. Findings on the functional performance of GA building show that cleaning, friendliness, parking space, landscaping and indoor climate are the top five rated. Findings also reveal that lack of awareness about POE is a top-rated barrier, followed by a lack of orientation of stakeholders and a lack of adequately trained staff.Originality/valueThe study contributes to the body of knowledge on POE, particularly in universities by conducting an empirical evaluation of both technical and functional performance of the University of Uyo buildings. Besides, it establishes a set of factors that significantly hinder the implementation of POEs in universities. From a practice perspective, it provides valid feedback on which universities can build upon to improve conditions of their facilities and ultimately bolster the conducive environment for teaching and learning.
Training, productivity and performance: lessons from a chilean retailer
Authors: Rexworthy Jane 
Published: March 2020

Purpose
A project to improve productivity in one of the largest retail firms in Latin America demonstrates how a tailor-made training intervention can improve workers’ performance and how — and by how much — investing in soft-skills can lead to productivity gains.

Design/methodology/approach
Individual-level longitudinal information gathered from the firm.

Findings
The training intervention was shown to have a positive and significant effect on both store-level sales and transactions per worker. This result was confirmed by a cost/benefit analysis. This provides clear evidence that productivity can be boosted with a high quality, well-designed and optimally-delivered training programme targeted to increase socio-emotional skills. This assertion has been corroborated by an empirical analysis of the project carried out by specialists from the Inter-American Development Bank and the Department of Economics, University of Maryland.

Originality/value
The project is one of the first to be subject to a detailed analysis to provide evidence of the causal impact of training on direct productivity measures.
Negative memorable experience: North American and British Airbnb guests’ perspectives
Authors: Sthapit Erose , Björk Peter , Jiménez Barreto Jano 
Published: March 2020

PurposeThis paper aims to explore the components of a negative memorable Airbnb experience.Design/methodology/approachTwo studies of North American and British nationals were conducted online using an open-ended survey questionnaire with photo-elicitation via Amazon Mechanical Turk (MTurk). The grounded theory was used to analyse the collected data.FindingsThe findings of the current study are destination-specific and generalisation is limited. In addition, this study gathered data using an open-ended survey questionnaire with visual images (photo-elicitation technique) in MTurk. Moreover, the study participants were mainly Westerners.Research limitations/implicationsAirbnb could provide hosts with a service quality checklist to warrant quality assurance across listings. Hosts must be informed, guided and monitored so that service quality standards are fulfilled. In addition, hosts should be incentivised to write an honest and accurate description of their listing.Practical implicationsAirbnb can provide hosts with a service quality checklist to ensure standardisation and quality assurance across listings. Hosts must be informed, guided and monitored so that service quality standards are fulfilled. In addition, hosts might benefit from training or workshops on the role of hosting and service quality management.Originality/valueThis is one of the first studies to explore the components of a negative memorable experience in the context of Airbnb.
Enhancing hospitality and tourism graduate employability through the 2u2i program
Authors: Mohd Yusof Mohd Fadil , Wong Anthony , Ahmad Ghazali , Che Aziz Roslizawati , Hussain Kashif 
Published: March 2020

Purpose
The purpose of this paper is to present the concept of 2u2i – two years attachment with university and two years attachment with industry – a new learning mode introduced by the Ministry of Education as a strategy to enhance the employability of university undergraduate degree students in Malaysia.

Design/methodology/approach
The new mode of undergraduate degree program requires the university and industry to collaborate on the design of the curriculum and development of student training programs. Based on a series of qualitative discussions, the paper draws on the perspectives of university administrators and selected practitioners from the hospitality and tourism industry who are interested in developing 2u2i curriculum and working together to enhance the overall employability of university graduates. The paper explains the issues and challenges in implementing the 2u2i program at a local public university as a case study in Malaysia.

Findings
The 2u2i program provides a significant opportunity for industry to collaborate with the university in enhancing competencies and relevant skills among degree graduates so that they are able to excel in the workplace. Some of the issues and challenges involve bureaucratic procedures, time constraints in developing the program with industry, delay in approval procedures of the program and extra costs highlighted in managing the program with industry. Despite several challenges relating to the implementation of the program, it is important for industry to collaborate with universities in designing relevant curriculum to augment the employability skills of university graduates in Malaysia.

Originality/value
This paper explores different strategies for engaging with industry practitioners so that they are able to work closely with the university in crafting academic curricula in the hospitality and tourism field. This is important because it enhances university graduate employability via a relevant curriculum based on input from the industry.
Using the Nondonor Distribution to Improve Communication and Inform Decision Making for Low LRs from Minor Contributors in Mixed DNA Profiles
Authors: Schuerman Curt , Kalafut Tim , Buchanan Clint , Sutton Joel , Bright Jo‐Anne 
Published: March 2020

AbstractThe reporting of a likelihood ratio (LR) calculated from probabilistic genotyping software has become more popular since 2015 and has allowed for the use of more complex mixtures at court. The meaning of “inconclusive” LRs and how to communicate the significance of low LRs at court is now important. We present a method here using the distribution of LRs obtained from nondonors. The nondonor distribution is useful for examining calibration and discrimination for profiles that have produced LRs less than about 104. In this paper, a range of mixed DNA profiles of varying quantity were constructed and the LR distribution considering the minor contributor for a number of nondonors was compared to the expectation given a calibrated system. It is demonstrated that conditioning genotypes should be used where reasonable given the background information to decrease the rate of nondonor LRs above 1. In all 17 cases examined, the LR for the minor donor was higher than the nondonor LRs, and in 12 of the 17 cases, the 99.9 percentile of the nondonor distribution was lower when appropriate conditioning information was used. The output of the tool is a graph that can show the position of the LR for the person of interest set against the nondonor LR distribution. This may assist communication between scientists and the court.
Oligopolistic equilibrium and financial constraints
Authors: Beviá Carmen , Corchón Luis C. , Yasuda Yosuke 
Published: March 2020

AbstractWe model a dynamic duopoly in which firms can potentially drive their rivals from the market. For some parameter values, the Cournot equilibrium outcome cannot be sustained in an infinitely repeated setting. In those cases, there is a Markov perfect equilibrium in mixed strategies in which one firm, eventually, will exit the market with probability one. Producer surplus in the maximum collusive outcome is greater under bankruptcy consideration, because the outcome that maximizes joint profits is skewed in favor of the more efficient firm. Consumer surplus and social welfare also increase in many cases, although those effects are generally ambiguous.
Factors related to rapid progression of non‐small cell lung cancer in Chinese patients treated using single‐agent immune checkpoint inhibitor treatment
Authors: Zhang Liang , Bai Lianwei , Liu Xianhong , Liu Ying , Li Shuang , Liu Jingjing , Zhang Shuang , Yang Changliang , Ren Xiubao , Cheng Ying 
Published: March 2020

AbstractBackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the treatment of non‐small cell lung cancer (NSCLC). While rapid progression (RP) has been proposed as a non‐negligible pattern of response to ICIs, its definition and related factors remain unclear. This study aimed to develop a clinical definition of RP and to identify related factors.MethodsWe retrospectively evaluated Chinese patients who had received an ICI as second‐line or later treatment for locally advanced or metastatic NSCLC at a single center. We defined RP as radiological progression at the first response assessment (<2 months after starting the ICI), as well as confirmation of progressive disease or cancer‐related death occurring at <3 months. The clinical outcomes were compared for patients with RP or non‐RP to identify prognostic factors.ResultsThe study evaluated 74 eligible patients with detailed records regarding their ICI therapy, including 25 patients (33.8%) who had experienced RP. Relative to patients with non‐RP, patients with RP had significantly shorter median progression‐free survival (1.7 months [95% CI: 1.4–2.0 months] vs. 6.3 months [95% CI 5.2–7.3 months], P < 0.001; hazard ratio: 0.14, 95% CI: 0.08–0.25) and significantly shorter median overall survival (8.2 months [95% CI 3.0–13.4 months] vs. 22.6 months [95% CI 17.0–28.1 months], P < 0.001; hazard ratio: 0.27, 95% CI: 0.15–0.49). Multivariate analysis revealed that RP was independently predicted by the presence of ≥3 metastatic sites (P = 0.039) and a neutrophil‐to‐lymphocyte ratio of ≥3 (P = 0.044).ConclusionsAmong NSCLC patients, RP was a common response to ICI monotherapy and was associated with dramatically reduced progression‐free and overall survival. Care is needed when selecting ICI monotherapy for these patients, especially if they have ≥3 metastatic sites or a neutrophil‐to‐lymphocyte ratio of ≥3.Key pointsSignificant findings of the study: Patients with rapid progression after immune checkpoint inhibitor monotherapy had poor survival outcomes. The number of metastatic sites and the neutrophil‐to‐lymphocyte ratio may independently predict treatment response in this setting.What this study adds: This is the first study to evaluate rapid progression after second‐line or later single‐agent immunotherapy in a Chinese population. Our findings may help establish effective immunotherapy strategies for NSCLC.
viewshed3d: An r package for quantifying 3D visibility using terrestrial lidar data
Authors: Lecigne Bastien , Eitel Jan U. H. , Rachlow Janet L. 
Published: March 2020

Abstract

Visual information affects animal behaviour and fitness in diverse ways, but a lack of suitable methods to quantify visibility in three‐dimensional (3D) environments limits applications of the concept of visibility in ecological research.

The viewshed3d r package is dedicated to quantifying the visual environment from a single location or from a cumulation of viewpoints based on 3D point clouds acquired with terrestrial laser scanning. We present the entire workflow required to prepare the data and perform the visibility analyses in viewshed3d.

This approach can help unlock the potential contributions of viewshed analyses to the emerging subdiscipline of ‘viewshed ecology’.
Adolescent nicotine induces depressive and anxiogenic effects through ERK 1‐2 and Akt‐GSK‐3 pathways and neuronal dysregulation in the nucleus accumbens
Authors: Hudson Roger , Green Matthew , Wright Daniel J. , Renard Justine , Jobson Christina E.L. , Jung Tony , Rushlow Walter , Laviolette Steven R. 
Published: March 2020

AbstractLong‐term tobacco dependence typically develops during adolescence and neurodevelopmental nicotine exposure is associated with affective disturbances that manifest as a variety of neuropsychiatric comorbidities in clinical and preclinical studies, including mood and anxiety‐related disorders. The nucleus accumbens shell (NASh) is critically involved in regulating emotional processing, and both molecular and neuronal disturbances in this structure are associated with mood and anxiety‐related pathologies. In the present study, we used a rodent model of adolescent neurodevelopmental nicotine exposure to examine the expression of several molecular biomarkers associated with mood/anxiety‐related phenotypes. We report that nicotine exposure during adolescence (but not adulthood) induces profound upregulation of the ERK 1‐2 and Akt‐GSK‐3 signalling pathways directly within the NASh, as well as downregulation of local D1R expression that persists into adulthood. These adaptations were accompanied by decreases in τ, α, β, and γ‐band oscillatory states, hyperactive medium spiny neuron activity with depressed bursting rates, and anxiety and depressive‐like behavioural abnormalities. Pharmacologically targeting these molecular and neuronal adaptations revealed that selective inhibition of local ERK 1‐2 and Akt‐GSK‐3 signalling cascades rescued nicotine‐induced high‐γ‐band oscillatory signatures and phasic bursting rates in the NASh, suggesting that they are involved in mediating adolescent nicotine‐induced depressive and anxiety‐like neuropathological trajectories.
Extended ex vivo normothermic perfusion for preservation of vascularized composite allografts
Authors: Fahradyan Vahe , Said Sayf Al‐deen , Ordenana Carlos , Dalla Pozza Edoardo , Frautschi Russell , Duraes Eliana F. R. , Madajka‐Niemeyer Maria , Papay Frank A. , Rampazzo Antonio , Bassiri Gharb Bahar 
Published: March 2020

AbstractIschemia and reperfusion injury remains a significant limiting factor for the successful revascularization of amputated extremities. Ex vivo normothermic perfusion is a novel approach to prolong the viability of the amputated limbs by maintaining physiologic cellular metabolism. This study aimed to evaluate the outcomes of extended ex vivo normothermic limb perfusion (EVNLP) in preserving the viability of amputated limbs for over 24 hours. A total of 10 porcine forelimbs underwent EVNLP. Limbs were perfused using an oxygenated colloid solution at 38°C containing washed RBCs. Five forelimbs (Group A) were perfused for 12 hours and the following 5 (Group B) until the vascular resistance increased. Contralateral forelimbs in each group were preserved at 4°C as a cold storage control group. Limb viability was compared between the 2 groups through assessment of muscle contractility, compartment pressure, tissue oxygen saturation, indocyanine green (ICG) angiography and thermography. EVNLP was performed for 12 hours in group A and up to 44 hours (24‐44 hours) in group B. The final weight increase (−1.28 ± 8.59% vs. 7.28 ± 15.05%, P = .548) and compartment pressure (16.50 ± 8.60 vs. 24.00 ± 9.10) (P = .151) were not significantly different between the two groups. Final myoglobin and CK mean values in group A and B were: 875.0 ± 325.8 ng/mL (A) versus 1133.8 ± 537.7 ng/mL (B) (P = .056) and 53 344.0 ± 16 603.0 U/L versus 64 333.3 ± 32 481.8 U/L (P = .286). Tissue oxygen saturation was stable until the end in both groups. Infra‐red thermography and ICG‐angiography detected variations of peripheral limb perfusion. Our results suggest that extended normothermic preservation of amputated limbs is feasible and that the outcomes of prolonged EVNLP (>24 hours) are not significantly different from short EVNLP (12 hours).
Endemic Burkitt lymphoma – an aggressive childhood cancer linked to Plasmodium falciparum exposure, but not to exposure to other malaria parasites
Authors: Quintana Maria del Pilar , Smith‐Togobo Cecilia , Moormann Ann , Hviid Lars 
Published: March 2020

Burkitt lymphoma (BL) is an aggressive non‐Hodgkin lymphoma. The prevalence of BL is ten‐fold higher in areas with stable transmission of Plasmodium falciparum malaria, where it is the most common childhood cancer, and is referred to as endemic BL (eBL). In addition to its association with exposure to P. falciparum infection, eBL is strongly associated with Epstein–Barr virus (EBV) infection (>90%). This is in contrast to BL as it occurs outside P. falciparum‐endemic areas (sporadic BL), where only a minority of the tumours are EBV‐positive. Although the striking geographical overlap in the distribution of eBL and P. falciparum was noted shortly after the first detailed description of eBL in 1958, the molecular details of the interaction between malaria and eBL remain unresolved. It is furthermore unexplained why exposure to P. falciparum appears to be essentially a prerequisite to the development of eBL, whereas other types of malaria parasites that infect humans have no impact. In this brief review, we summarize how malaria exposure may precipitate the malignant transformation of a B‐cell clone that leads to eBL, and propose an explanation for why P. falciparum uniquely has this capacity.
Adult height in patients with childhood‐onset inflammatory bowel disease: a nationwide population‐based cohort study
Authors: Mouratidou Natalia , Malmborg Petter , Sachs Michael C. , Askling Johan , Ekbom Anders , Neovius Martin , Smedby Karin E. , Sävendahl Lars , Ludvigsson Jonas F. , Olén Ola 
Published: March 2020

SummaryBackgroundGrowth retardation is well described in childhood‐onset inflammatory bowel disease (IBD).AimsTo study if childhood‐onset IBD is associated with reduced final adult height.MethodsWe identified 4201 individuals diagnosed with childhood‐onset IBD 1990‐2014 (Crohn's disease: n = 1640; ulcerative colitis: n = 2201 and IBD‐unclassified = 360) in the Swedish National Patient Register.ResultsPatients with IBD attained a lower adult height compared to reference individuals (adjusted mean height difference [AMHD] −0.9 cm [95% CI −1.1 to −0.7]) and to their healthy siblings (AMHD −0.8 cm [−1.0 to −0.6]). Patients with Crohn’s disease (CD) were slightly shorter than patients with ulcerative colitis (UC; −1.3 cm vs −0.6 cm). Lower adult height was more often seen in patients with pre‐pubertal disease onset (AMHD −1.6 cm [−2.0 to −1.2]), and in patients with a more severe disease course (AMHD −1.9 cm, [−2.4 to −1.4]). Some 5.0% of CD and 4.3% of UC patients were classified as growth retarded vs 2.5% of matched reference individuals (OR 2.42 [95% CI 1.85‐3.17] and 1.74 [1.36‐2.22] respectively).ConclusionPatients with childhood‐onset IBD on average attain a slightly lower adult height than their healthy peers. Adult height was more reduced in patients with pre‐pubertal onset of disease and in those with a more severe disease course.
Modelling NAFLD disease burden in four Asian regions—2019‐2030
Authors: Estes Chris , Chan Henry L. Y. , Chien Rong N. , Chuang Wan‐Long , Fung James , Goh George Boon-Bee , Hu Tsung H. , Huang Jee‐Fu , Jang Byoung K. , Jun Dae W. , Kao Jia H. , Lee Jin‐Woo , Lin Han‐Chieh , Razavi‐Shearer Kathryn , Seto Wai‐Kay , Wong Grace L. ‐H. , Wong Vincent W. ‐S. , Razavi Homie 
Published: March 2020

SummaryBackgroundNon‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) account for an increasing proportion of liver disease in the Asia‐Pacific region. Many areas in the region are experiencing epidemics of metabolic syndrome among rapidly ageing populations.AimsTo estimate using modelling the growth in NAFLD populations, including cases with significant fibrosis that are most likely to experience advanced liver disease and related mortality.MethodsA disease progression model was used to summarise and project fibrosis progression among the NAFLD populations of Hong Kong, Singapore, South Korea and Taiwan. For each area, changes in the adult prevalence of obesity was used to extrapolate long‐term trends in NAFLD incidence.ResultsIn the areas studied, prevalent NAFLD cases were projected to increase 6%‐20% during 2019‐2030, while prevalent NASH cases increase 20%‐35%. Incident cases of hepatocellular carcinoma are projected to increase by 65%‐85%, while incident decompensated cirrhosis cases increase 65%‐100% by 2030. Likewise, NAFLD‐related mortality is projected to increase between 65% and 100% from 2019 to 2030. NAFLD disease burden is expected to increase alongside rising trends in metabolic syndrome and obesity among populations in the region. This leads to more cases of advanced liver disease and associated mortality.ConclusionsPreventing the growth of diabetic and obese populations will be a key factor in reducing ongoing increases in NAFLD‐related disease burden in the Asia‐Pacific region.