bluuebunny/crossref_metadata_2025_split huggingface dataset:
A BMI-category distribution pattern of intrinsic and treatment-related prognostic factors in endometrial cancer
Authors: Kurosu Hiroyuki , Todo Yukiharu , Yamada Ryutaro , Minowa Kaoru , Tsuruta Tomohiko , Minobe Shinichiro , Kato Hidenori 
Published: December 2020

Abstract

Objective
In patients with endometrial cancer, obesity is associated with favorable prognostic characteristics but not with prolonged survival. The aim of this study was to elucidate the reason for this clinical paradox.

Methods
We retrospectively reviewed 1173 patients with endometrial cancer. Patients were divided into a non-obese group [body mass index (BMI) &lt; 30 kg/m2], class I obesity group (BMI 30–35 kg/m2) and class II obesity group (BMI ≥ 35 kg/m2). The relationship between clinicopathological factors and disease-specific survival (DSS) was analyzed by Cox regression analysis. To correct for three-time significance testing, we used the Bonferroni method, giving the level of probability at which findings were considered significant as P &lt; 0.0167.

Results
Three disease-intrinsic variables—older age, advanced stage and high-risk histology—and three treatment-related variables—no hysterectomy, no lymphadenectomy and no chemotherapy—were independently associated with poor DSS. DSS was similar among the three groups of patients even though the proportion of patients with plural pretreatment-related unfavorable risk factors significantly decreased with increment of BMI category (40.1 vs. 27.5 vs. 17.6%, P = 0.0003). The proportion of patients with plural treatment-related unfavorable prognostic factors significantly increased with increment of BMI category (21.3 vs. 26.7 vs. 39.3%, P = 0.0072).

Conclusions
Poor-quality surgical staging in obese women may result in worse than expected survival outcomes.
Deliberation and Deliberative Organizational Routines in Frontline Decision-Making
Authors: Møller Anne Mette 
Published: December 2020

AbstractDeliberation is a widely recognized but understudied aspect of frontline decision-making. This study contributes to theory development by exploring deliberative practices in frontline organizations and their implications for decision-making. Drawing on a multi-sited ethnographic study in three Danish child welfare agencies, the analysis clarifies the multiple purposes of deliberation in everyday practice and shows how deliberation is enabled and structured by formalized and informal deliberative organizational routines. Findings show that deliberation may influence individual decision-making or amount to collective decision-making. Depending on how deliberative organizational routines are enacted, deliberation may serve to enhance professional judgment, ensure appropriate justification for decisions, and alleviate uncertainty and emotional strain. Yet, while deliberation represents a productive form of collective coping, deliberative routines may also obscure transparency and reify dysfunctional group dynamics. A conceptual framework is developed to support further research into the purposes, practices, and implications of deliberation across diverse street-level contexts.
Bronchoalveolar lavage fluid IMMY Sona Aspergillus lateral-flow assay for the diagnosis of invasive pulmonary aspergillosis: a prospective, real life evaluation
Authors: Arkell P , Mahboobani S , Wilson R , Fatania N , Coleman M , Borman A M , Johnson E M , Armstrong-James D P H , Abdolrasouli A 
Published: December 2020

Abstract

Prompt and reliable diagnosis of invasive pulmonary aspergillosis (IPA) is essential for early initiation of antifungal therapy. We evaluated bronchoalveolar lavage (BAL) fluid IMMY Sona Aspergillus lateral-flow assay (IMMY LFA) in 92 individuals with suspected pulmonary infection. Sensitivity and specificity (vs. host factor but no IPA) of BAL IMMY LFA for diagnosis of IPA in individuals with any European Organisation for Research and Treatment of Cancer-defied “host factor” were 67% and 85%, respectively. Performance appeared better in individuals with renal transplantation (100%, 100%), compared to those with hematological malignancy and/or allogenic stem cell transplantation (70%, 78%). We found BAL IMMY LFA to be a convenient and useful addition to our diagnostic armory for IPA.

Lay abstract
We evaluated a new test for diagnosing invasive pulmonary aspergillosis from bronchoscopy samples. We tested 92 people and found that it was 67% sensitive and 85% specific (compared to diagnosis according to a set of internationally recognised criteria). We found this test convenient and useful.
The fast radio burst dispersion measure distribution
Authors: Arcus W R , Macquart J-P , Sammons M W , James C W , Ekers R D 
Published: December 2020

ABSTRACT
We compare the dispersion measure (DM) statistics of FRBs detected by the ASKAP and Parkes radio telescopes. We jointly model their DM distributions, exploiting the fact that the telescopes have different survey fluence limits but likely sample the same underlying population. After accounting for the effects of instrumental temporal and spectral resolution of each sample, we find that a fit between the modelled and observed DM distribution, using identical population parameters, provides a good fit to both distributions. Assuming a one-to-one mapping between DM and redshift for an homogeneous intergalactic medium (IGM), we determine the best-fitting parameters of the population spectral index, $\hat{\alpha }$, and the power-law index of the burst energy distribution, $\hat{\gamma }$, for different redshift evolutionary models. Whilst the overall best-fitting model yields $\hat{\alpha }=2.2_{-1.0}^{+0.7}$ and $\hat{\gamma }=2.0_{-0.1}^{+0.3}$, for a strong redshift evolutionary model, when we admit the further constraint of α = 1.5 we favour the best fit $\hat{\gamma }=1.5 \pm 0.2$ and the case of no redshift evolution. Moreover, we find no evidence that the FRB population evolves faster than linearly with respect to the star formation rate over the DM (redshift) range for the sampled population.
Allosteric effects of SSB C-terminal tail on assembly ofE. coliRecOR proteins
Authors: Shinn Min Kyung , Kozlov Alexander G , Lohman Timothy M 
Published: December 2020

AbstractEscherichia coli RecO is a recombination mediator protein that functions in the RecF pathway of homologous recombination, in concert with RecR, and interacts with E. coli single stranded (ss) DNA binding (SSB) protein via the last 9 amino acids of the C-terminal tails (SSB-Ct). Structures of the E. coli RecR and RecOR complexes are unavailable; however, crystal structures from other organisms show differences in RecR oligomeric state and RecO stoichiometry. We report analytical ultracentrifugation studies of E. coli RecR assembly and its interaction with RecO for a range of solution conditions using both sedimentation velocity and equilibrium approaches. We find that RecR exists in a pH-dependent dimer-tetramer equilibrium that explains the different assembly states reported in previous studies. RecO binds with positive cooperativity to a RecR tetramer, forming both RecR4O and RecR4O2 complexes. We find no evidence of a stable RecO complex with RecR dimers. However, binding of RecO to SSB-Ct peptides elicits an allosteric effect, eliminating the positive cooperativity and shifting the equilibrium to favor a RecR4O complex. These studies suggest a mechanism for how SSB binding to RecO influences the distribution of RecOR complexes to facilitate loading of RecA onto SSB coated ssDNA to initiate homologous recombination.
Impaired Performance in Mental Rotation of Hands and Feet and Its Association with Social Cognition in Patients with Complex Regional Pain Syndrome
Authors: Lee Dasom , Choi Soo-Hee , Noh Eunchung , Lee Won Joon , Jang Joon Hwan , Moon Jee Youn , Kang Do-Hyung 
Published: December 2020

Abstract

Objectives.
So far, dysfunction in mental rotation has been assessed in relation to the left- or right-sided CRPS. Here we examined mental rotation in patients with upper or lower limb CRPS. Considering the potential role of socio-emotional functioning on the perception of body image, we further investigated the association between performance on mental rotation and socio-emotional characteristics.

Methods.
We examined the performance of 36 patients with upper or lower limb CRPS on the limb laterality recognition. Accuracy and response times for pictures of hands and feet at 4 rotation angles were evaluated. Socio-emotional functioning was measured by the Interpersonal Reactivity Scale and the Toronto Alexithymia Scale.

Results.
Patients with upper limb pain showed longer RTs to recognize the laterality of hands than feet (P = 0.002), whereas patients with lower limb pain showed longer RTs for feet than hands (P = 0.039). Exploratory correlation analyses revealed that RTs for feet were negatively correlated with the levels of empathic ability to take another’s perspective (P = 0.006) and positively correlated with the level of emotional difficulty in identifying feelings (P = 0.006).

Conclusions.
This study is the first to report selectively impaired mental rotation of hands vs feet in patients with upper or lower limb CRPS. The findings suggest that impaired mental rotation derives from relative deficits in the representation of the affected limb. Correlations between impaired mental rotation and socio-emotional inability indicate that an altered body schema may be closely associated with impaired social cognitive aspects in CRPS patients.
The Loss of Capacity in Public Organizations: A Public Administration Challenge
Authors: Ansell Christopher K , Comfort Louise , Keller Ann , LaPorte Todd , Schulman Paul 
Published: December 2020

Abstract
Important challenges to the administrative, policy-making, and implementation capacities of public organizations have arisen in recent years. These challenges may arise from many quarters, including budget cuts, organizational reforms, and most ominously, political subterfuge. Although limits on capacity may be familiar to the public organizations that must cope with them, they are less well understood by outside observers. This analytical gap undermines our ability to appraise the policy and constitutional implications of capacity loss. To begin the process of deepening our knowledge of public sector organizational capacities, this essay calls for greater investment in understanding the organizational dynamics associated with capacity loss.
The CHY-Type Zinc Finger Protein FgChy1 Regulates Polarized Growth, Pathogenicity, and Microtubule Assembly in Fusarium graminearum
Authors: Cao Shulin , Li Wei , Li Chaohui , Wang Guanghui , Jiang Wenqiang , Sun Haiyan , Deng Yuanyu , Chen Huaigu 
Published: December 2020

Microtubules (MTs), as transport tracks, play important roles in hyphal-tip growth in filamentous fungi, but MT-associated proteins involved in polarized growth remain unknown. Here, we found that one novel zinc finger protein, FgChy1, is required for MT morphology and polarized growth in Fusarium graminearum. The Fgchy1 mutant presented curved and directionless growth of hyphae. Importantly, the conidia and germ tubes of the Fgchy1 mutant exhibited badly damaged and less-organized beta-tubulin cytoskeletons. Compared with the wild type, the Fgchy1 mutant lost the ability to maintain polarity and was also more sensitive to the anti-MT drugs carbendazim and nocodazole, likely due to the impaired MT cytoskeleton. Indeed, the hyphae of the wild type treated with nocodazole exhibited a morphology consistent with that of the Fgchy1 mutant. Interestingly, the disruption of FgChy1 resulted in the off-center localization of actin patches and the polarity-related polarisome protein FgSpa2 from the hyphal-tip axis. A similar defect in FgSpa2 localization was also observed in the nocodazole-treated wild-type strain. In addition, FgChy1 is also required for conidiogenesis, septation, sexual reproduction, pathogenicity, and deoxynivalenol production. Overall, this study provides the first demonstrations of the functions of the novel zinc finger protein FgChy1 in polarized growth, development, and virulence in filamentous fungi. [Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Complete Chromosome-Scale Genome Sequence Resource forSporisorium panici-leucophaei, the Causal Agent of Sourgrass Smut Disease
Authors: Crestana Gustavo Schiavone , Taniguti Lucas Mitsuo , dos Santos Clesivan Pereira , Benevenuto Juliana , Ceresini Paulo Cezar , Carvalho Giselle , Kitajima João Paulo , Monteiro-Vitorello Claudia Barros 
Published: December 2020

Here, we present the first complete chromosome-level genome assembly of the smut fungus strain Sporisorium panici-leucophaei SPL10A, the causal agent of the sourgrass (Digitaria insularis) smut disease. Combining Illumina paired-end and Nanopore long reads, we generated a final assembly composed of 23 chromosomes (22 nuclear and one mitochondrial) with 18,915,934 bp. Gene prediction accomplished using extrinsic evidence from the sugarcane smut fungus Sporisorium scitamineum originated a total of 6,402 protein-encoding genes. The secretome (388 proteins) and the effectorome repertoires (68 candidates) were also predicted, given their crucial roles in plant-pathogen interactions. The complete telomere-to-telomere chromosome sequences of this poorly studied fungus will provide a valuable resource for future comparative genomic studies among smuts to unravel their underlying pathogenicity mechanisms.[Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Positive Regulatory Domain I–binding Factor 1 Mediates Peripheral Nerve Injury–induced Nociception in Mice by Repressing Kv4.3 Channel Expression
Authors: Wang Cunjin , Pan Yuchen , Zhang Wenwen , Chen Ying , Li Chuhan , Zhao Fang , Behnisch Thomas 
Published: December 2020

Background
The transcriptional repressor positive regulatory domain I–binding factor 1 (PRDM1) is expressed in adult mouse dorsal root ganglion and regulates the formation and function of peripheral sensory neurons. The authors hypothesized that PRDM1 in the dorsal root ganglion may contribute to peripheral nerve injury–induced nociception regulation and that its mechanism may involve Kv4.3 channel transcriptional repression.

Methods
Nociception was induced in C57BL/6 mice by applying chronic constriction injury, complete Freund’s adjuvant, or capsaicin plantar injection. Nociceptive response was evaluated by mechanical allodynia, thermal hyperalgesia, cold hyperalgesia, or gait analysis. The role of PRDM1 was evaluated by injection of Prdm1 knockdown and overexpression adeno-associated viruses. The interaction of PRDM1 at the Kv4.3 (Kcnd3) promoter was evaluated by chromatin immunoprecipitation assay. Excitability of dorsal root ganglion neurons was evaluated by whole cell patch clamp recordings, and calcium signaling in spinal dorsal horn neurons was evaluated by in vivo two-photon imaging.

Results
Peripheral nerve injury increased PRDM1 expression in the dorsal root ganglion, which reduced the activity of the Kv4.3 promoter and repressed Kv4.3 channel expression (injured vs. uninjured; all P < 0.001). Knockdown of PRDM1 rescued Kv4.3 expression, reduced the high excitability of injured dorsal root ganglion neurons, and alleviated peripheral nerve injury–induced nociception (short hairpin RNA vs. Scram; all P < 0.05). In contrast, PRDM1 overexpression in naive mouse dorsal root ganglion neurons diminished Kv4.3 channel expression and induced hyperalgesia (PRDM1 overexpression vs. control, mean ± SD; n = 13; all P < 0.0001) as evaluated by mechanical allodynia (0.6 ± 0.3 vs. 1.2 ± 0.2 g), thermal hyperalgesia (5.2 ± 1.3 vs. 9.8 ± 1.7 s), and cold hyperalgesia (3.4 ± 0.5 vs. 5.3 ± 0.6 s). Finally, PRDM1 downregulation in naive mice reduced the calcium signaling response of spinal dorsal horn neurons to thermal stimulation.

Conclusions
PRDM1 contributes to peripheral nerve injury–induced nociception by repressing Kv4.3 channel expression in injured dorsal root ganglion neurons.

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A Novel “Eccentric” Therapeutic Approach for Individuals Recovering From COVID-19
Authors: Gurovich Alvaro N. , Tiwari Sangeeta , Kehl Stephanie , Umucu Emre , Peñailillo Luis 
Published: December 2020

ABSTRACT
Since its appearance in December 2019, COVID-19 has sparked an unprecedented global health care and economic crisis with a fallout predicted to last well into the foreseeable future. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible of COVID-19. The detrimental effects of COVID-19 in the human body have 2 major sources: (1) the infection per se and (2) prolonged bed rest time, which might include hospitalization and even intensive care unit admittance. In addition, the COVID-19 pandemic has altered the mental health status of both healthy and COVID-19 ill persons. It is expected that millions of people will recover from COVID-19; however, their physical and mental health status during recovery might take longer than expected due to the massive inflammation, profound muscle waste, and several unknown consequences, especially in the cardiorespiratory system. Under this perspective, eccentric exercise training might raise as a therapeutic alternative to efficiently improve the physical and mental health status of patients recovering from COVID-19, as previously reported in patients with cancer and chronic pulmonary disease. The purpose of the present clinical perspective is to describe how an eccentric exercise training program might expedite physical and mental recovery in individuals recovering from COVID-19 based on SARS-CoV-2 pathophysiology and evidence-based eccentric exercise training in clinical populations.
Autism Spectrum Disorder Parent Report for Outcome Monitoring: A Preliminary Report of Development and Clinical Utility
Authors: Levin April R. , Baumer Nicole , Amaral Joseph , Sargado Sabrina , Pawlowski Katherine , Chiujdea Madeline , Schmitt Rachel , Weissman Laura , Chan Eugenia , Sideridis Georgios , Bridgemohan Carolyn 
Published: December 2020

ABSTRACT:

Objective:
Children with autism spectrum disorder (ASD) face challenges across many functional domains. A tool that gathers relevant clinical information before visits, emphasizing symptoms that are likely to change over development and inform clinical interventions, could improve health care quality, allowing for more patient-centered and efficient care. This study evaluated the clinical utility and preliminary psychometrics of the ASD Parent Report for Outcome Monitoring (ASD-PROM), a web-based measure assessing competence in core features of ASD, along with the breadth of concerns and comorbidities that frequently co-occur with ASD.

Methods:
An interdisciplinary team drafted the ASD-PROM and made iterative revisions based on parent feedback. Parents of 62 children completed the ASD-PROM before their autism-specialty clinical visit, 53 completed the ASD-PROM twice, and 48 completed the Vineland Adaptive Behavior Scales, Second Edition (Vineland-II) concurrently. Parents (n = 25) and clinicians (n = 13) completed postvisit surveys to assess utility (phase 1). The ASD-PROM was then released for general clinical use (phase 2).

Results:
On a Likert scale (1 = very poorly, 10 = very well), parents found that ASD-PROM items described their child's abilities well (median = 8.0; interquartile range [IQR]: 7.0–9.5) and had a positive effect on care (median = 8.0; IQR: 7.0–10.0). Clinicians found the ASD-PROM effective in assessing parent-reported patient abilities (median = 9.0, IQR: 7.0–9.0) and felt the ASD-PROM helped make their care more patient-centered and efficient (both median = 8.0, IQR: 6.0–9.0). Two-week test-retest reliability was acceptable (0.95). ASD-PROM scores correlated positively with scores from similar domains on the Vineland-II (Pearson r 0.30–0.50, medium to large effects).

Conclusion:
The ASD-PROM is a freely available tool to gather information on developmental and behavioral functioning in children with ASD before autism-specialty clinical visits. Clinical utility and preliminary psychometrics are promising, although limitations (including a low response rate during clinical use and a need for additional in-depth assessments and potential resulting modifications to the tool) remain to be addressed. Ultimately, the ASD-PROM may help promote patient-centered and efficient care for children across a wide range of ages and developmental levels.
Associations Between Participation in After-School Activities, Attention-Deficit/Hyperactivity Disorder Severity, and School Functioning
Authors: Lax Yonit , Brown Suzette N. , Silver Michael , Brown Nicole M. 
Published: December 2020

ABSTRACT:

Objective:
To examine the association between after-school activity (ASA) participation, attention-deficit/hyperactivity disorder (ADHD) severity, and school functioning among children with ADHD.

Methods:
A cross-sectional study was conducted using data from the 2016 National Survey of Children's Health on ADHD severity, ASAs and 2 domains of school functioning among children with ADHD: missed days from school and calls home from school.

Results:
Of 4,049 children with ADHD (weighted N = 5,010,662), 71.8% participated in at least 1 ASA. In multivariable regression analyses, ASA participation was associated with lower odds of moderate-to-severe ADHD [adjusted odds ratio (aOR): 0.62, 95% confidence interval (CI), 0.46–0.85] and lower odds of missed school days (aOR 0.55, 95% CI, 0.41–0.74). We did not find significant associations with calls home from school (aOR 0.79, 95% CI, 0.59–1.07).

Conclusion:
After-school activity participation is associated with decreased ADHD severity and reduced school absenteeism. Efforts to optimize ADHD outcomes should consider engaging children and adolescents in ASAs.
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats
Authors: Miotto Danyelle S. , Duchatsch Francine , Macedo Anderson G. , Ruiz Thalles F.R. , Vicentini Carlos A. , Amaral Sandra L. 
Published: December 2020

Abstract:
Sympathetic activity, arteriolar structure, and angiogenesis are important mechanisms modulating hypertension and this study aimed to analyze the effects of perindopril treatment, associated or not with exercise training, on the mechanisms that control blood pressure (BP) in hypertensive rats. Spontaneously hypertensive rats (SHR) were allocated into 4 groups: 1/sedentary (S); 2/perindopril (P, 3.0 mg/kg/d); 3/trained (T); and 4/trained + perindopril (TP). Wistar rats were used as normotensive sedentary control group. SHR were assigned to undergo a treadmill training (T) or were kept sedentary. Heart rate, BP, sympathetic activity to the vessels (LF-SBP), and skeletal muscle and myocardial morphometric analyses were performed. BP was significantly lower after all 3 strategies, compared with S and was accompanied by lower LF-SBP (−76%, −53%, and −44%, for P, T, and TP, respectively). Arteriolar vessel wall cross-sectional area was lower after treatments (−56%, −52%, and −56%, for P, T, and TP, respectively), and only TP presented higher arteriolar lumen area. Capillary rarefaction was present in soleus muscle and myocardium in S group and both trained groups presented higher vessel density, although perindopril attenuated this increase in soleus muscle. Although myocyte diameter was not different between groups, myocardial collagen deposition area, higher in S group, was lower after 3 strategies. In conclusion, we may suggest that perindopril could be an option for the hypertensive people who practice exercise and need a specific pharmacological treatment to reach a better BP control, mainly because training-induced angiogenesis is an important response to facilitate blood flow perfusion and oxygen uptake and perindopril did not attenuate this response.