bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in multiple intestinal neoplasia (Min) mice
Authors: Raposo Teresa P. , Alfahed Abdulaziz , Nateri Abdolrahman S. , Ilyas Mohammad 
Published: June 2020

SummaryApcMin/+ mice are regarded as a standard animal model of colorectal cancer (CRC). Tensin4 (TNS4 or Cten) is a putative oncogene conferring features of stemness and promoting motility. Our objective was to assess TNS4 expression in intestinal adenomas and determine whether TNS4 is upregulated by Wnt signalling. ApcMin/+ mice (n = 11) were sacrificed at approximately 120 days old at the onset of anaemia signs. Small intestines were harvested, and Swiss roll preparations were tested for TNS4 expression by immunohistochemistry (IHC). Individual polyps were also separately collected (n = 14) and tested for TNS4 mRNA expression and Kras mutation. The relationship between Wnt signalling and TNS4 expression was tested by Western blotting in the human CRC cell line HCT116 after inhibition of β‐catenin activity with MSAB or its increase by transfection with a Flag β‐catenin expression vector. Overall, 135/148 (91.2%) of the total intestinal polyps were positive for TNS4 expression by IHC, whilst adjacent normal areas were negative. RT‐qPCR analysis showed approximately 5‐fold upregulation of TNS4 mRNA in the polyps compared to adjacent normal tissue and no Kras mutations were detected. In HCT116, β‐catenin inhibition resulted in reduced TNS4 expression, and conversely, β‐catenin overexpression resulted in increased TNS4 expression. In conclusion, this is the first report linking aberrant Wnt signalling to upregulation of TNS4 both during initiation of intestinal adenomas in mice and in in vitro models. The exact contribution of TNS4 to adenoma development remains to be investigated, but the ApcMin/+ mouse represents a good model to study this.
Laboratory intercomparison for the evaluation of the delamination propensity of glass containers for pharmaceutical use
Authors: Guglielmi Massimo , Bessegato Nicola , Cerdan‐Diaz Juan , Choju Ken , Lisman Dave , Flynn Carol Rea , Guadagnino Emanuel , Meysner Amy , Pfeifer Joachim , Roehl Holger , Rupertus Volker , Scarpa Martina , Sun Huimin , Zhang Jingwei , Zuccato Daniele 
Published: June 2020

AbstractThis paper is the result of two round robin activities run by the Technical Committee TC12, Pharma Packaging, of the International Commission on Glass (ICG). It deals with the phenomenon of delamination, that is, the formation of lamellae or flakes in drug products due to specific and localized corrosion of glass vials, and it follows a first paper PDA J Pharm Sci Technol. 2018, 72, 553–565where a testing protocol for the evaluation of the delamination propensity was proposed. The results showed that the protocol gives information on the quality of vials with respect to the propensity to corrosion, but no direct correlation with delamination could be demonstrated, as no lamellae formation was observed.In response, further testing was carried out on five sets of vials with expected low delamination propensity, compared to a set of vials with high expected delamination propensity using both the proposed protocol and a more aggressive protocol. The objective was to observe lamellae at least in the high propensity vials to show a correlation to initial test protocols.The results show that there is a very good consistency between the results of the two testing protocols and therefore, with a good level of reliability, the degree of glass surface corrosion can be estimated by the testing protocol proposed by the Technical Committee. In some cases, the glass surface corrosion results may indicate an increased risk of delamination (depending on the individual interaction between the pharmaceutical solution and the inner vial surface).
Evaluation of DOAC Filter, a new device to remove direct oral anticoagulants from plasma samples
Authors: Sevenet Pierre‐Olivier , Cucini Virginie , Hervé Tristan , Depasse François , Carlo Audrey , Contant Geneviève , Mathieu Olivier 
Published: June 2020

AbstractIntroductionDirects oral anticoagulants (DOACs) can interfere with coagulation assays, especially in thrombophilia workup. To avoid these interferences, a new device, DOAC Filter, allows the removal of DOACs from citrated plasma. This study aims to confirm that DOAC Filter efficiently removes DOACs and to ascertain that coagulation assays are not impacted by filtration.MethodsDirects oral anticoagulants Filter (Diagnostica Stago, France) is a filtration cartridge in which DOAC molecules are trapped by noncovalent binding, while plasma is filtered through a solid phase. Normal pool plasma (NPP) spiked with DOACs up to 300 ng/mL, with dabigatran etexilate (n = 27), rivaroxaban (n = 35), apixaban (n = 33), and edoxaban (n = 27) or 120 ng/mL for betrixaban (n = 4), and 18 plasma's samples from DOAC‐treated patients were used to assess efficacy. The potential impact of DOAC Filter on coagulation assays was evaluated with NPP and plasma's samples from positive and negative lupus anticoagulant (LA) patients.ResultsDirects oral anticoagulants concentrations measured after filtration were below the limit of detection (LoD) of DOAC‐specific assays for all plasmas tested, except for one apixaban plasma sample, with postfiltration concentration slightly higher than anti‐Xa assay LoD (25.1 ng/mL). Coagulation assays results varied between −4 and +8% after filtration and between −6 and +8% for LA plasmas. Such limited variations are not expected to have any clinical impact.ConclusionDirects oral anticoagulants Filter efficiently removes DOACs from plasma and achieves concentrations below DOAC‐specific assays LoD, except in the case of one apixaban sample. The integrity of plasma is respected, and the cartridge seems not to impact LA diagnosis.
Oral non-steroidal anti-inflammatory drug use in recreational runners participating in Parkrun UK: Prevalence of use and awareness of risk
Authors: Rosenbloom Craig James , Morley Faye L , Ahmed Imran , Cox Anthony Richard 
Published: June 2020

Abstract

Objective
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in endurance running and by elite athletes. We examined the pattern of use of NSAIDs, the purpose of use and knowledge of the adverse effects of NSAID use in a population of recreational runners at Parkrun UK.

Methods
An online observational non-interventional cross-sectional survey of Parkrun UK participants being over the age of 18, on Parkrun UK’s mailing list, and residing in the UK.

Key Findings
Runners (n = 806) had a high use of NSAIDs in the past 12 months (87.8%). The average age of respondents was 48.39 years. There was a significant association between those taking an oral NSAID in the last twelve months and those with a sporting injury (χ2 = 10.89, df = 1, n = 797, P = 0.001). Ibuprofen was the most commonly used NSAID (81.1%). A third of runners had experienced an adverse drug reaction associated with NSAIDs, usually gastrointestinal. Half of runners used NSAIDs with no advice, and patient information leaflets were the most common source for those that had advice. Ninety-four per cent of runners would like more information on the harms and benefits of NSAIDs.

Conclusions
Some recreational runners have a high use of NSAIDs, which is chronic in nature and a potential health risk. Recreational runners want more information on the harms and benefits of NSAIDs. Race event organizers should provide evidence-based advice on the use of NSAIDs.
Improving and standardizing metabolic screening for people prescribed antipsychotic medication who are at risk of developing metabolic syndrome within the community mental health setting
Authors: Hackett Debbie , Fitzgerald Catriona 
Published: June 2020

AbstractAim and objective of the audit. The purpose of this audit was to identify the number of people prescribed antipsychotic medication who are at risk of developing metabolic syndrome in a community mental health service area with the aim of improving and standardising metabolic screening practices within this setting. Community mental health services are secondary care services in which individuals are referred from Primary Care (General Practitioners). The catchment area of this audit is within the South East Region of Ireland and offers adults community mental health services to a population of approximately 57 000. For the purpose of this audit we focused on one community mental health team within the service.
COVID‐19 pandemic in France: health emergency experiences from the field
Authors: Chamboredon P. , Roman C. , Colson S. 
Published: June 2020

AimThis paper describes the situation regarding COVID‐19 emergency in France as of early May 2020, the main policies to fight this virus, and the roles and responsibilities of nurses regarding their work at this time, as well as the challenges facing the profession.BackgroundEurope continues to be affected by the COVID‐19 pandemic. At the time of writing France was the fourth country with the highest number of detected cases and cumulative deaths.Sources of evidenceWebsites of the World Health Organization, French Government, French Agency of Public Health, French National Council of Nurses and ClinicalTrials.gov database, as well as the experiences of the authors.DiscussionThe history of the development of the pandemic in France helps explain the establishment of the state of health emergency and containment of the population. Many decisions made had undesirable repercussions, particularly in terms of intra‐family violence, mental health disorders and the renunciation of care. Hospitals and primary care services, with significant investment by nurses, played a key role in the care of persons with and without COVID‐19.ConclusionFrance has suffered a very high toll in terms of COVID‐19 morbidity and mortality, and effects on its people, health systems and health professionals, including nurses.Implications for nursing practiceNurses are recognized for their social usefulness in France. However, it is important to consider the collateral effects of this crisis on nurses and nursing and to integrate the health emergency nursing skills established during the pandemic into the standard field of nursing competence.Implications for nursing policyThe nursing profession has expectations of a reflection on and revision of nursing skills as well as of its valorization in the French healthcare system, notably carried out by the French National Council Order of Nurses.
Large‐scale synthesis of hollow carbon fibers with ultra‐large diameter by thermally controlled pyrolysis
Authors: Yuan Ye , Xiong Yayuan , Li Jianjun , Yin Weilong , Peng Qingyu , Lu Haibao , Li Yibin , He Xiaodong 
Published: June 2020

AbstractHollow carbon fibers (HCF) with ultra‐large diameter have been synthesized and the versatility to convert them into the corresponding carbon‐based composites has been demonstrated. The hollow carbon fibers were fabricated by thermal controlled carbonization of electrospun polyacrylonitrile fibers. For the existence of inorganic silica shell during pyrolysis, heat release will be blocked at the boundary, driving the polyacrylonitrile precursor fiber to form hollow structure. The diameter of the as‐prepared hollow carbon fibers can exceed 150 nm. Sol‐gel‐derived Fe3O4 nanoparticles can grow on the outer‐surface and the inner‐surface of hollow carbon fibers. The microwave absorption performance of ternary HCF@Fe3O4@PPy composite is testified and the values of reflection loss exceeding −10 dB can be obtained in the frequency of 3.3‐11.3 GHz. The large diameter of hollow carbon fibers can have inner and outer interfaces in the corresponding composites, which make them great potential for a variety of applications in future.
Synroc technology: Perspectives and current status (Review)
Authors: Gregg Daniel J. , Farzana Rifat , Dayal Pranesh , Holmes Rohan , Triani Gerry 
Published: June 2020

AbstractDr Eric (Lou) Vance spent 32 years at the Australian Nuclear Science and Technology Organisation (ANSTO), where he was dedicated to the development of Synroc technology, a waste treatment solution for intractable nuclear wastes. The original form of Synroc, a multiphase ceramic wasteform based on stable and leach resistant titanate minerals, was invented by Australian scientists in the late 1970s. This formulation was directed toward the immobilization of PUREX wastes from the reprocessing of nuclear fuels. Synroc at ANSTO under the scientific leadership of Dr Vance since evolved beyond these original titanate ceramics into a waste treatment technology platform. This platform can be applied to produce glass, glass‐ceramic and ceramic wasteforms and offers distinct advantages in terms of waste loading and suppressing volatile losses. The platform therefore provides an opportunity to treat those waste streams that are problematic for glass matrices alone or existing vitrification process technologies. Such wastes include, for example, actinide‐bearing wastes, those that contain large proportions of refractory elements, those with significant fission product or corrosive volatile emissions and those wastes resulting from radiopharmaceutical production. The implementation of the latter will see the industrialization of Synroc technology via a first‐of‐a‐kind Synroc Waste Treatment Facility that is currently under construction at ANSTO. This paper will review Synroc technology, particularly noting the substantial and essential contributions from the late Dr Vance. The review will also provide some perspective on the development of the technology for nuclear waste immobilization and describe the significant recent advancements at ANSTO.
The effects of (di‐,tri‐valent)‐cation partitioning and intercalant anion‐type on the solubility of hydrotalcites
Authors: Prentice Dale P. , Gomez‐Zamorano Lauren , Balonis Magdalena , Erdemli Bartu , Ellison Kirk , Neithalath Narayanan , Simonetti Dante , Sant Gaurav 
Published: June 2020

AbstractSynthetic hydrotalcites were produced by a co‐precipitation method. The hydrotalcites are represented by the general formula [MII(1‐x)MIII(x)(OH)2][An−]x/n·zH2O, where MII is a divalent cation (eg, Mg2+or Ca2+), MIII is a trivalent cation (eg, Al3+) and An− is the interlayer anion. Herein, MII = Mg, and MIII = Al such that [Mg/Al] = [2, 3] (atomic units) and An−, represents intercalant species including: OH−, SO42− and CO32− anions. The thermochemical data of each compound including their solubility constants (Kso), density and molar volume were quantified at T = 25 ± 0.5°C, and P = 1 bar. The solubilities of the synthetic hydrotalcites, irrespective of their divalent‐trivalent cation partitioning ratio, scaled as CO32− < SO42− < OH−; in order of decreasing solubility. The type of anion, very slightly, affected the solubility with less than ±1 log unit of variation for [Mg/Al] = 2, and ±2 log units of variation for [Mg/Al] = 3. The solubilities of these phases were strongly correlated with that of gibbsite (Al(OH)3); such that activity of the [AlO2−] species was solubility determining with increasing pH. The tabulated thermodynamic data were used to construct solid‐solution models for phases encompassing both cation distribution ratios and to calculate stable phase equilibria relevant to alkali‐activated slag (AAS) systems for diverse activator compositions.
B‐site‐doped BiFeO3‐based piezoceramics with enhanced ferro/piezoelectric properties and good temperature stability
Authors: Shi Yunjing , Yan Fei , He Xia , Huang Kaiwei , Shen Bo , Zhai Jiwei 
Published: June 2020

AbstractHere, B‐site doped 0.725BiFe0.98M0.02O3‐0.275BaTiO3 (M = Fe, Sc, Ga, and Al) + 0.8 mol% MnO2 (abbreviated as BF, BS, BG, and BA) (BFM‐BT) ceramics were designed and prepared to modulate octahedral distortions. According to bond‐valence calculations based on XRD Rietveld refinement data, B‐site doped BFM‐BT ceramics tended to have a higher distortion as the radius of the doping ion decreases, and obtained a great improvement of ferroelectric and piezoelectric performances. B‐site‐doped BFM‐BT ceramics significantly inhibited the formation of impurities, leading to better ferroelectric and piezoelectric performances. The BFM‐BT ceramics exhibited high Curie temperature of 519‐530℃ and good temperature stability for piezoelectric performances. The d33 values of BF, BS, and BA ceramics remained the room temperature value ranging from room temperature to 470℃. Meanwhile the content of impure phases, oxygen vacancies and valence of Fe3+ to Fe2+ decreased with the decreasing radii of B‐site doping ions.
Enhanced ferroelectric and ferromagnetic properties of BiFeO3‐PbTiO3 multiferroic solid solutions with Ba substitutions
Authors: Peng Rui , Jian Jie , Xu Zhoushang , Chen Yixuan , Chen Jianguo , Cheng Jinrong 
Published: June 2020

AbstractDense 0.6(Bi0.9La0.1)(Ga0.05Fe0.95)O3‐0.4(Pb1‐xBax)TiO3 (BLGF‐PBT, x = 0, 0.1, 0.2, 0.3, and 0.4) ceramics with different Ba contents were prepared by the solid‐state reaction method, and effects of Ba contents on the structure and multiferroic properties were investigated. X‐ray diffraction results indicate that the Ba‐modified BLGF‐PBT ceramics exhibit single perovskite structure without detectable secondary phases, and a transition from tetragonal phase to rhombohedral one takes place with the increase of Ba content. The piezoelectric constant d33, remanent polarization Pr, and remanent magnetization Mr are improved by the Ba substitution simultaneously. Values of Pr, Mr, and d33 of BLGF‐PBT ceramics for the composition of x = 0.3 with the coexistence of tetragonal and rhombohedral phases are 20 μC/cm2, 0.05 emu/g, and 256 pC/N, respectively, much higher than those without Ba modification. The significantly improved d33 and Mr indicate that BLGF‐PBT ceramics with Ba modification provide alternative materials for multifunctional devices.
Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro
Authors: Zhang Jie , Ding Changling , Zhang Shuping , Xu Yangyang 
Published: June 2020

AbstractAstaxanthin (ATX), which is the most abundant flavonoid in propolis, has previously shown neuroprotective properties against cerebral ischaemia‐induced apoptosis. However, the mechanisms by which ATX mediates its therapeutic effects are unclear. At present, we explored the underlying mechanisms involved in the protective effects of ATX via the phosphoinositide 3‐kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3β)/nuclear factor erythroid 2‐related factor 2 (Nrf2) signalling pathway in SH‐SY5Y cells. The PI3K/Akt inhibitor LY294002 and GSK3β inhibitor LiCl were employed in this study. Pre‐treatment with ATX for 24 hours significantly decreased the oxygen and glucose deprivation (OGD)‐induced viability loss, reduced the proportion of apoptosis and regulated OGD‐mediated reactive oxygen species (ROS) production. Furthermore, ATX suppressed OGD‐caused mitochondrial membrane potential and decomposition of caspase‐3 to cleaved caspase‐3, and heightened the B‐cell lymphoma 2 (Bcl‐2)/Bax ratio. PI3K/Akt/GSK3β/Nrf2 signalling pathway activation in SH‐SY5Y cells was verified by Western blot. ATX and LiCl treatment raised the protein levels of p‐Akt, p‐GSK3β, nucleus Nrf2 and haeme oxygenase 1 (HO‐1). However, these protein expression levels decreased by treatment of LY294002. The above in vitro data indicate that ATX can confer neuroprotection against OGD‐induced apoptosis via the PI3K/Akt/GSK3β/Nrf2 signalling pathway.
Serological diversity in Flavobacterium psychrophilum: A critical update using isolates retrieved from Chilean salmon farms
Authors: Avendaño‐Herrera Ruben , Tapia‐Cammas Diana , Duchaud Eric , Irgang Rute 
Published: June 2020

AbstractChile is currently the second largest producer of farmed salmon worldwide, but Flavobacterium psychrophilum, as one of the most detrimental pathogens, is responsible for major losses during the freshwater culturing step in salmonid fish farms. An antigenic study conducted 10 years ago reported four serological groups using 20 F. psychrophilum Chilean strains. To reduce disease outbreaks and to develop vaccine candidates, antigenic knowledge needs to be regularly updated using a significant number of additional recent F. psychrophilum isolates. The present study aimed at investigating the serological diversity of 118 F. psychrophilum isolates collected between 2006 and 2018 from farmed Atlantic salmon (Salmo salar), rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch). The current study supports an expansion of the known antigenic groups in Chile from 4 to 14. However, the use of the slide‐agglutination technique for serotyping is costly, is labour‐intensive and requires significant technical expertise. Addressing these points, the mPCR‐based procedure was a very useful tool for serotyping the collected Chilean F. psychrophilum isolates. This technique revealed the presence of diverse mPCR serotypes (i.e. types 0, 1, 2 and 4). Therefore, mPCR should be employed to select the bacterial strain(s) for vaccine development and to conduct follow‐up, selective breeding or epidemiological surveillance in Chilean fish farms. Given the presented findings, changes to Chilean fish‐farming practices are vital for ensuring the continued productivity and well‐being of farmed salmonids.
Wastewater treatment system optimization with an industrial symbiosis model: A case study of a Chinese eco‐industrial park
Authors: Hu Wanqiu , Tian Jinping , Li Xing , Chen Lujun 
Published: June 2020

AbstractIn Chinese industrial parks, the centralized wastewater treatment plant (CWWTP) is an essential shared infrastructure to further purify the in‐plant pretreated industrial wastewater. Most of the contaminants, such as organic matter, are removed by in‐plant wastewater treatment to guarantee the safety and efficiency of the CWWTP. Carbon source shortages are common in the denitrification process in CWWTPs, and such issues are generally solved by adding external carbon sources, such as glucose. Some biodegradable organics that are abundant in industrial wastewater, such as food production wastewater, can be utilized as the external carbon sources for denitrification. This study proposed an industrial symbiosis‐based model to optimize the wastewater treatment system in industrial parks by reusing organic matter in food wastewaters as the external carbon source for advanced treatment processes in CWWTPs. A case study of a Chinese eco‐industrial park is investigated to verify the technical and economic feasibility of the model. The case study indicates that the overall cost‐savings potential of the model is approximately 6.55 million Chinese Yuan (CNY) per year, accounting for approximately 20% of the annual operating cost of the CWWTP. Additionally, the mitigation potential of greenhouse gas (GHG) emissions is 5977 t CO2‐eq per year, accounting for 1.7% of the GHG emissions of the original model. Furthermore, potential barriers to implementing the IS model and the relevant policy implications are discussed.