bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Related Factors of Dyslipidemia among Adults Aged 35 to 79 years in Southwest China
Authors: Huang Chuan , Zhang Wen-Qiang , Tang Wei-Wei , Liu Ya , Liu Jian-Xiong , Xu Rong-Hua , Zhao Shui-Ping , Wang Tzung-Dau , Huang Xiao-Bo 
Published: January 2021

Abstract
This study aimed to investigate the prevalence of dyslipidemia and its related factors among adults aged 35 to 79 years in southwest China. From September 2013 to March 2014, a multi-stage, stratified sampling was conducted on 10221 people aged 35–79 years living in Chengdu and Chongqing by using the method of field questionnaire survey and measurement. The prevalence of high triglycerides (≥ 2.3 mmol/L), high total cholesterol (≥ 6.2 mmol/L), high low-density lipoprotein cholesterol (≥ 4.1 mmol/L), low high-density lipoprotein cholesterol (< 1.0 mmol/L), and dyslipidemia were 15.7%, 5.4%, 2.5%, 5.7%, and 27.4%, respectively. The prevalence of dyslipidemia was positively correlated with higher education level, monthly income over 2000 yuan, smoking, hypertension, diabetes, overweight and obesity, and central obesity, and negatively correlated with daily physical exercise. The prevalence of dyslipidemia in southwest China is lower than the national average level, but on the rise, with high triglycerides as the main type of dyslipidemia.
A Rise in Percentages of Circulating Lymphocyte Subsets Correlates With Acute Rejection in Liver Transplant Recipients
Authors: Pan Fei , Cao Shuang , Li Xian-Liang , Xu Wen-Li , Li Han , Jia Ya-nan , He Qiang , Zhu Jiqiao 
Published: January 2021

Abstract
Background: Little is known about the shift of circulating lymphocyte subsets following liver transplantation and thus, its relationship with acute rejection. Methods: Liver transplant recipients were enrolled to assess the effect of primary liver diseases, gender, age, and follow-up periods on the shift of circulating lymphocyte subsets. Moreover, patients with rejection were paired to assess the effect of the shift on rejection.Results: When compared with patients from the middle-term group (29-180 d) and the long-term group (>180 d), patients from the short-term group (< 29 d) had the lowest absolute counts of T cell subsets, NK cells and NK T cells, and the lowest percentages of T cell subsets, B cells, NK cells and NK T cells but the highest percentage of DC. However, other factors did not affect circulating lymphocyte subsets. Percentages of T cells, CD4+T cells, B cells and NK T cells were higher in patients with acute rejection while percentages of T cell subsets and NK cells decreased after anti-rejection treatment. The percentage of NK T cells was identified to be the only independent predictor for acute rejection. The predicted probability was calculated using binary logistic with the area under the curve of 0.89, which had a sensitivity of 70.6% and a specificity of 94.1% at a cut-off value of 0.69.Conclusions: Circulating lymphocyte subsets gained a global recovery over the post-transplant period, leading to a sharp rise in percentages of circulating lymphocyte subsets, which was in close relation to the occurrence of acute rejection.
A glycoside analog of mammalian oligomannose formulated with a TLR4-stimulating adjuvant elicits HIV-1 cross-reactive antibodies
Authors: Bruxelle Jean-Francois , Kirilenko Tess , Trattnig Nino , Yang Yiqiu , Cattin Matteo , Kosma Paul , Pantophlet Ralph 
Published: January 2021

Abstract
The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM197-conjugate of a previously reported oligomannose mimetic. Oligomannose-specific bnAbs that are less dependent on interactions with the HIV envelope protein sequence showed strong binding to the glycoconjugates, with affinities approximating those reported for their cognate epitope. The glycoconjugate is also recognized by germline precursors of oligomannose-specific bnAbs, albeit with the expected low avidity, supporting its potential as an immunogen. Immunization of human-antibody transgenic mice revealed that only a TLR4-stimulating adjuvant formulation evoked antibodies able to bind a panel of recombinant HIV trimers. These antibodies bound at relatively modest levels, likely explaining their inability to neutralize HIV infectivity. Nevertheless, these findings contribute further to understanding conditions for eliciting HIV-cross-reactive oligomannose-specific antibodies and inform on next steps for improving on the elicited response.
Associations between neighborhood violence during pregnancy and birth outcomes: Evidence from São Paulo’s Western Region Birth Cohort
Authors: Santos Angélica Carreira dos , Brentani Alexandra , Fink Günther 
Published: January 2021

Abstract
Background: Low birth weight and prematurity remain leading causes of infant mortality and morbidity globally. Although extensive literature has highlighted the importance of socioenvironmental characteristics for birth outcomes, the role of indirect violence on health remains fairly understudied.Methods: Using geocoded birth records from the ongoing Western Region Birth Cohort (Região Oeste Coorte – ROC-Cohort) of infants born between 2012-2014 and geocoded crime reports, we assessed the associations between exposure to violent crimes during pregnancy within a 1-km radius of the mother’s residence and low birth weight, preterm delivery, and being born small-for-gestational-age. Violent crime exposure was categorized into quintiles. Multivariate logistic regressions were used to examine the associations between violence exposure and birth outcomes. Models were adjusted for sex, maternal age and education, socioeconomic status, and risk factors such as hypertension, diabetes, smoking, and drinking during pregnancy.Results: Among the 5,268 infants included, the average crime exposure during the first two trimesters of pregnancy ranged from 0.44 violent crimes in the least exposed quintile to 12.74 crimes in the most exposed. Compared to children with the lowest violence exposure, children in the highest exposure quintile had higher odds of being born small-for-gestational-age (1.41[1.06-1.89]), preterm (1.35[1.01-1.80]), and low birth weight (1.42[1.03-1.98]). While socioeconomic status and maternal education were positively associated with lower violence exposure, no associations were found between these characteristics and birth outcomes.Conclusions: Higher exposure to violent crimes in the close vicinity of pregnant women’s residence is associated with substantial increases in the odds of adverse birth outcomes. Policies to improve neighborhood safety can potentially contribute not only to the short-term wellbeing of populations but may also have large social, economic, and health benefits in the long term.
Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocular Hypertension Treatment - A Phase II Controlled Study
Authors: Rubião Francine , Araújo Alan Cezar Faria , Sancio João Bernardo , Nogueira Bárbara Silva , Franca Juçara Ribeiro , Nogueira José Carlos , Ferreira Anderson José , Faraco André Augusto Gomes , Foureaux Giselle , Cronemberger Sebastião 
Published: January 2021

Introduction:
The most common treatment for Primary Open-Angle Glaucoma (POAG)
is the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve
patient adherence by achieving prolonged therapeutic drug concentrations in ocular target tissues
while limiting systemic exposure. The purpose of this study is to compare the efficacy and
safety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and Ocular Hypertension
(OH).

Methods:
We include OH and POAG patients aged between 40 and 75 years-old. Both OH and
POAG patients had intraocular pressure (IOP) greater than 21 and ≤30 mmHg at 9:00 am without
glaucoma medication and normal biomicroscopy. Five normal patients with IOP≤14 mmHg constitute
the control group. A chitosan-based insert of bimatoprost was placed at the upper conjunctival
fornix of the right eye. In the left eye, patients used one drop of LumiganTM daily at 10:00 pm.
For statistical analysis, a two-way analysis of variance (ANOVA), Student t-test, and paired t-test
is used.

Results:
Sixteen POAG and 13 OH patients with a mean age of 61 years were assessed. In both
eyes, IOP reduction was similar during three weeks of follow-up (19.5±2.2 mmHg and 16.9±3.1
mmHg), insert, and eye drop, respectively; P=0.165). The percentage of IOP reduction in the third
week was 30% for insert and 35% for eye drops (P=0.165). No intolerance or discomfort with the
insert was reported. Among the research participants, 58% preferred the use of the insert while
25% preferred eye drops, and 17% reported no preference.

Conclusions:
Bimatoprost-loaded inserts showed similar efficacy to daily bimatoprost eye drops
during three weeks of follow up, without major side effects. This might suggest a possible change
in the daily therapeutic regimen for the treatment of POAG and OH.
A Systematic Review of the MDMA Model to Address Social Impairment in Autism
Authors: Chaliha Devahuti , Mamo John C. , Albrecht Matthew , Lam Virginie , Takechi Ryu , Vaccarezza Mauro 
Published: January 2021

Background:
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by repetitive
behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, no gold-standard treatments exist
to alleviate the core socio-behavioural impairments of ASD. Meanwhile, the prosocial empathogen/entactogen 3,4-
methylene-dioxy-methamphetamine (MDMA) is known to enhance sociability and empathy in both humans and animal
models of psychological disorders.

Objective:
We review the evidence obtained from behavioural tests across the current literature, showing how MDMA can
induce prosocial effects in animals and humans, where controlled experiments were able to be performed.

Methods:
Six electronic databases were consulted. The search strategy was tailored to each database. Only Englishlanguage papers were reviewed. Behaviours not screened in this review may have affected the core ASD behaviours studied.
Molecular analogues of MDMA have not been investigated.

Results:
We find that the social impairments may potentially be alleviated by postnatal administration of MDMA producing
prosocial behaviours in mostly the animal model.

Conclusion:
MDMA and/or MDMA-like molecules appear to be an effective pharmacological treatment for the social
impairments of autism, at least in animal models. Notably, clinical trials based on MDMA use are now in progress.
Nevertheless, larger and more extended clinical studies are warranted to prove the assumption that MDMA and MDMA-like
molecules have a role in the management of the social impairments of autism.
A Mini Review on Surface-Enhanced Raman Scattering based Nanoclusters
for Sensing and Imaging Applications
Authors: Chokkareddy Rajasekhar , Kanchi Suvardhan , Inamuddin  
Published: January 2021

Background:
The invention of enhanced Raman scattering by adsorbing molecules on nanostructured metal
surfaces is a milestone in the development of spectroscopic and analytical techniques. Important experimental and
theoretical efforts were geared towards understanding the Surface Enhanced Raman Scattering effect (SERS) and evaluating
its significance in a wide range of fields in different types of ultrasensitive sensing applications.

Methods:
Metal nanoclusters have been widely studied due to their unique structure and individual properties, which place
them among single metal atoms and larger nanoparticles. In general, the nanoparticles with a size less than 2 nm is defined
as nanoclusters (NCs) and they possess distinct optical properties. In addition, the excited electrons from absorption bands
results in the emission of positive luminescence associated to the quantum size effect in which separate energy levels are
produced.

Results:
It is demonstrated that fluorescent based SERS investigations of metal nanoparticles have showed more
photostability, high compatibility, and good water solubility, has resulted in high sensitivity, better imaging and sensing
experience in the biomedical applications.

Conclusion:
In the present review, we report recent trends in the synthesis of metal nanoclusters and their applications in
biosensing and bio-imaging applications due some benefits including cost-effectiveness, easy synthesis routes and less
consumption of sample volumes. Outcomes of this study confirms that SERS based fluorescent nanoclusters could be one
of thrust research areas in biochemistry and biomedical engineering.
Nano-sheets of Graphene Oxide Enhance the Combined Effect of Hyperthermia and Radiation Treatment in Pancreatic Cancer Cell Lines
Authors: Haqiqian Mohammad H. , Sardari Dariush , Houshyari Mohammad , Moghadasali Reza 
Published: January 2021

Background:
Pancreatic cancer leaves little hope for survival among patients. This is due
to its cancerous cell resistance to radiation and chemicals.

Objective:
Synergistic effect between three modalities of pancreatic cancer treatment is investigated.
These are radiation therapy, hyperthermia and graphene oxide nanosheets. The aim is to overcome
resistance of pancreatic cancer cells against radiation therapy.

Methods:
Cancerous cell lines were treated by each one of three modalities separately. Other samples
were treated with various combinations of these modalities. Hyperthermia was accomplished by
placing cell lines for 15 min in 42°C. In the course of radiation therapy, the cancerous cells were
irradiated by 6 MV Linac for two cases of 2 Gy and 3 Gy. The cell line viability was readout by
MTT assay 24 hours and 48 hours after treatment.

Results:
In single modality treatment it was shown that 24h after the treatment, the group treated by
RT 3 Gy had the highest cell killing result. Following up the result in 48h readout, hyperthermia and
3 Gy radiotherapy had similar results. In double modality treatment, for both 24h and 48h viability
readout, the group graphene-oxide plus 2 Gy radiotherapy showed cell survival amounting to 69%
and 43%, respectively being the lowest cell survival among all double combinations.

Conclusion:
In triple modality treatment, the cell viability for 24h showed no significant improvement
but in 48h, the hyperthermia plus Graphene-oxide and 3 Gy radiotherapy had very low cell
viability. Significant sensitizing effect for GO, when combined with radiation therapy, was observed.
Partial Fuzzy Quantifiers and their Computation
Authors: Novák Vilém , Burda Michal 
Published: January 2021

Background:In computer science, one often needs to deal with undefined values. For example, they naturally increase when a mistake such as the square root of a negative number or division by zero occurs. A similar problem occurs in the logical analysis of natural language. For example, the expression “Czech president in the 18th century” has no denotation because there was no Czech president before 1918. Such a situation in mathematics is characterized by partial functions, i.e., functions that may be undefined for specific arguments.Method:In this paper, we will extend the theory of intermediate quantifiers (i.e., expressions such as “most, almost all, many, a few,” etc.) to deal with partially defined fuzzy sets. First, we will extend algebraic operations that are used in fuzzy logic by the additional value “undefined.” Then we will introduce intermediate quantifiers using the former. The theory of intermediate quantifiers has been developed as a special theory of higher-order fuzzy logic.Results:In this paper, we introduce the quantifiers semantically and show how they can be computed. The latter is also demonstrated in three illustrative examples.Conclusion:The paper contributes to the development of fuzzy quantifier theory and its extension by undefined values and suggests methods for computation of truth values.
A New Cutset-type Kernelled Possibilistic C-means Clustering Segmentation
Algorithm Based on SLIC Super-pixels
Authors: Fan Jiulun , Yu Haiyan , Yan Yang , Gao Mengfei 
Published: January 2021

:
The kernelled possibilistic C-means clustering algorithm (KPCM) can effectively cluster hyper-sphere data
with noise and outliers by introducing the kernelled method to the possibilistic C-means clustering (PCM) algorithm.
However, the KPCM still suffers from the same coincident clustering problem as the PCM algorithm due to the lack of
between-class relationships. Therefore, this paper introduces the cut-set theory into the KPCM and modifies the
possibilistic memberships in the iterative process. Then a cutset-type kernelled possibilistic C-means clustering (CKPCM) algorithm is proposed to overcome the coincident clustering problem of the KPCM. Simultaneously a adaptive
method of estimating the cut-set threshold is also given by averaging inter-class distances. Additionally, a cutset-type
kernelled possibilistic C-means clustering segmentation algorithm based on the SLIC super-pixels (SS-C-KPCM) is also
proposed to improve the segmentation quality and efficiency of the color images. Several experimental results on artificial
data sets and image segmentation simulation results prove the excellent performance of the proposed algorithms in this
paper.
THE SHAPE OF ASSIKOâ€™ KANA (Hybrid Contract) ON MAKASSAR NATIVES : ETHNOMETHODOLOGY PERSPECTIVE
Authors: Syah Sultan - , Sukoharsono Eko Ganis , Saraswati Erwin - , - Roekhudin - 
Published: January 2021

ABSTRACTPurpose â€” The purpose of this research is to discuss the accounting shariâ€™a in assikkoâ€™ kana (hybrid contract) applied by Makassar natives by interpreting the existence of accounting in the trade activity area.Design/methodology/approach â€” In order to determine the existence of accounting, this research uses a qualitative method by using the ethnomethodology approach.Findings â€”Â The result reveals that accounting is the accountability process of economic, social, cultural, and religious aspects of the trade activities, which also can be found in the kalula[1] system. The research also finds that the trade actors are highly committed to trusting each other even though they incur losses. Thus this indicates that sociability becomes their priority. In addition, there is one more important factor so-called papalele (shareholders) whos contribute to the run of activities.Practical Implications â€” Â Banking, financial companies, and Islamic finance including capital owners can benefit from the preparation of assikkoâ€™ kana (hybrid contracts) so that the contracts made do not conflict with the prevailing Islamic ShariaOriginality/value â€” Â a hybrid contract form applied to the flying fish fishermen community (patorani) is the result of acculturation between local culture and Islamic law. What's interesting is that the majority of Islamic banking and financial products and services are hybrid contracts, but the source of funding is still sourced from local investors (papalele). This paper tries to make a reality in the patorani community in establishing Sharia parameters, about how to combine more than one contract in one transactionKeywords Accounting Shariâ€™a, Hybrid Contract, PatoraniPaper Type Research paperÂ
Approaches to Studying the Quality and Standard of Living in Russia
Authors: Arhipova Marina , Sirotin Vyacheslav 
Published: January 2021

The paper presents the major approaches to study the population’s standard of living. It describes current trends of the main indicators of various aspects of people’s lives, including the population’s quality of life, welfare, social issues, services available to the population, and environmental conditions. The favorable and negative trends in the development of a number of indicators under study have been identified. The authors have presented their methodology to develop an indicator of the population’s standard of living, which includes 40 specific indicators corresponding to various aspects of people’s standard of living.
The advantage of the proposed methodology is the possibility to take into account a wide range of indicators provided as part of official statistics, representing an objective picture of the people’s standard of living as well as the universal nature of the proposed indicator in terms of traceability of its measurements over time, which allows identifying the changes in the Russian regions and taking corrective actions in due time.
A ARTE DE APOSENTAR-SE: PROGRAMA DE PREPARAÇÃO PARA APOSENTADORIA COM POLICIAIS FEDERAIS
Authors: Penna Soares Dulce Helena , Novaes Luna Iúri , Bittencourt de Freitas Lima Marilaine 
Published: January 2021

RESUMO:O avanço da ciência e tecnologia tem levado a um progressivo aumento da longevidade e da expectativa de vida, proporcionando aos indivíduos usufruírem um tempo maior de suas existências como aposentados ainda gozando de boas condições físicas e mentais. Sendo assim, este artigo apresenta reflexões sobre o tema aposentadoria com base no relato do Programa Preparação para Aposentadoria (PPA), desenvolvido com Policiais Federais. O Programa foi realizado em três encontros, de oito horas cada, e caracterizou-se por abordar o assunto de forma vivencial, com a utilização de técnicas específicas para trabalhar temas como projetos de vida e reorientação profissional, considerando os diferentes aspectos que permeiam este momento de mudança (saúde, lazer, finanças, espiritualidade, família, etc). Constatou-se, tanto na teoria quanto na prática, que o processo de aposentadoria dos Policiais Federais envolve mudanças específicas que requerem reorganização familiar, afetiva e social, o que evidencia a importância do desenvolvimento de programas que trabalhem estes aspectos.PALAVRAS-CHAVE: Aposentadoria. Programa de Preparação para Aposentadoria. Policiais Federais. ABSTRACT:The advancement of science and technology has taken a progressive increase in longevity and life expectancy, letting people enjoy a longer period of their existence as a retiree still enjoying good physical and mental conditions. Therefore, this article presents reflections on the theme of retirement, based on the report of a Retirement Preparation Program (PPA) developed with Federal Policemen. This Program was conducted in three meetings, eight hours each one, and characterized by approaching the topic in an experiential way, using specific techniques to work themes such as life projects and professional reorientation considering the different aspects that permeate this time of change (health, leisure, finance, spirituality, family, etc.). It was found in theory and in practice that the retirement process of the Federal Policemen involves specific changes that require family, emotional and socialreorganization, which highlights the importance of developing programs to work these aspects. KEYWORDS: Retirement. Preparation Program for retirement. Federal Policemen.