bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retinal vessel oxygen saturation in patients with unilateral internal carotid artery stenosis: a pilot study
Authors: Zhang Wenbo , Li Liangliang , Zou Da , Ren Qiushi , Zhang Yadi , Kang Lei , Gu Xiaopeng , Wu Hailong , Zhang Shijie , Zhu Ruilin , Zhang Yanzhen , Yang Liu 
Published: June 2020

AbstractPurposeTo investigate the retinal vessel oxygen saturation in patients with internal carotid artery stenosis (ICAS).MethodsThis is a cross‐sectional study. Sixteen patients with unilateral moderate or worse ICAS (≥50%) and no fundus diseases were included in the study. Sixteen gender‐ and age‐matched healthy subjects were selected as controls. The mean oxygen saturation and vessel diameters of the retinal arterioles and venules were obtained using a dual‐wavelength spectrophotometric retinal oximeter.ResultsIn the eye of the stenotic side, the retinal vessel oxygen saturation was 100.14 ± 10.27% in the arterioles and 56.50 ± 10.79% in the venules, and the arteriovenous (A‐V) difference was 43.63 ± 7.71%. In the eye of the contralateral side, the oxygen saturation was 96.55 ± 7.50% in the arterioles and 57.42 ± 9.84% in the venules, and the A‐V difference was 39.39 ± 6.33%. In healthy subjects, the oxygen saturation was 93.22 ± 5.98% in the arterioles and 56.57 ± 7.05% in the venules, and the A‐V difference was 36.65 ± 7.33%. The arteriolar oxygen saturation in the stenotic side was higher than that in the contralateral side (p = 0.025) and that in the healthy subjects (p = 0.027), and the A‐V difference in the stenotic side was significantly higher than that in the contralateral side (p = 0.009) and that in the healthy subjects (p = 0.013). The diameters of the arterioles in the stenotic side were smaller than those in the healthy subjects (p = 0.030).ConclusionsPatients with ICAS had decreased retinal arteriole diameters and increased retinal vessel oxygen saturation in the arterioles and A‐V differences, suggesting the presence of microcirculation disorder and hyperoxia in the retina.
Explaining Leader Well‐Being in the Workplace from Leaders’ Identity, Reputation, and Charisma
Authors: Hirschfeld Robert R. , Bernerth Jeremy B. , Walker H. Jack 
Published: June 2020

Informed by evolutionary leadership theory, the current study investigates two forms of leader well‐being in the workplace as explained by leaders’ self‐perceived identity (i.e., self‐ratings of dark personality), follower‐judged reputation (i.e., subordinate‐ratings of leaders' dark personality), and attributed charisma. Results, based on data from 386 followers matched with 268 leaders, linked both a Dark Triad identity and a Dark Triad reputation to less perceived social worth and job satisfaction among leaders. Additional results found leader charisma surpassed a Dark Triad identity and reputation as an explanatory factor, a finding we attribute to the salience and observability of charisma to followers. Lastly, our results also indicate a leader identity × charisma interaction. The pattern of moderation suggests followers respond to leader charisma in ways that encourage a leader and thereby buffer the otherwise inimical consequences of a Dark Triad identity. Overall, our research suggests that leaders’ subjective quality of work life is shaped by an interplay between internal propensity and acclaim from followers in the form of attributed charisma. Implications for organizations and evolutionary leadership theory are discussed.
Tumor microenvironment in gastric cancers
Authors: Oya Yukiko , Hayakawa Yoku , Koike Kazuhiko 
Published: June 2020

AbstractThe tumor microenvironment favors the growth and expansion of cancer cells. Many cell types are involved in the tumor microenvironment such as inflammatory cells, fibroblasts, nerves, and vascular endothelial cells. These stromal cells contribute to tumor growth by releasing various molecules to either directly activate the growth signaling in cancer cells or remodel surrounding areas. This review introduces recent advances in findings on the interactions within the tumor microenvironment such as in cancer‐associated fibroblasts (CAFs), immune cells, and endothelial cells, in particular those established in mouse gastric cancer models. In mice, myofibroblasts in the gastric stroma secrete R‐spondin and support normal gastric stem cells. Most CAFs promote tumor growth in a paracrine manner, but CAF population appears to be heterogeneous in terms of their function and origin, and include both tumor‐promoting and tumor‐restraining populations. Among immune cell populations, tumor‐associated macrophages, including M1 and M2 macrophages, and myeloid‐derived suppressor cells (MDSCs), are reported to directly or indirectly promote gastric tumorigenesis by secreting soluble factors or modulating immune responses. Endothelial cells or blood vessels not only fuel tumors with nutrients, but also interact with cancer stem cells and immune cells by secreting chemokines or cytokines, and act as a cancer niche. Understanding these interactions within the tumor microenvironment would contribute to unraveling new therapeutic targets.
Buschke‐Ollendorff syndrome with LEMD3 germline stopgain mutation p.R678* presenting as multiple subcutaneous nodules with mucin deposition
Authors: Xu Zhijun , Yang Chao , Xue Ruzeng 
Published: June 2020

AbstractBuschke‐Ollendorff syndrome (BOS; OMIM 166700) is a rare autosomal dominant disorder characterized by the existence of connective tissue nevus and/or osteopoikilosis. The skin lesions usually present as firm, yellow, or flesh‐colored papules and nodules, which may coalesce into plaques and increase in size and number over time. We present a case of a 26‐year‐old male with multiple subcutaneous nodules on the waist and thigh for more than 20 years. Being deeply seated, his skin lesions were not visible and could only be appreciated by palpation. Accordingly, pathology showed an increase in thick, crossed, or paralleled, elastic fibers arranged between the collagen bundles in the lower part of the reticular dermis and the subcutaneous fat with mucin deposition. Heterozygous point mutation in exon 8 of the LEMD3 gene was detected, which confirmed the diagnosis of BOS. The deeply situated nature of skin lesions noted in our case has not been reported in the literature of BOS. Our case thus expands the clinical and pathological features of the disease.
Comprehensive data integration—Toward a more personalized assessment of diastolic function
Authors: Loncaric Filip , Cikes Maja , Sitges Marta , Bijnens Bart 
Published: June 2020

AbstractBackground and aimThe main challenge of assessing diastolic function is the balance between clinical utility, in the sense of usability and time‐efficiency, and overall applicability, in the sense of precision for the patient under investigation. In this review, we aim to explore the challenges of integrating data in the assessment of diastolic function and discuss the perspectives of a more comprehensive data integration approach.MethodsReview of traditional and novel approaches regarding data integration in the assessment of diastolic function.ResultsComprehensive data integration can lead to improved understanding of disease phenotypes and better relation of these phenotypes to underlying pathophysiological processes—which may help affirm diagnostic reasoning, guide treatment options, and reduce limitations related to previously unaddressed confounders. The optimal assessment of diastolic function should ideally integrate all relevant clinical information with all available structural and functional whole cardiac cycle echocardiographic data—envisioning a personalized approach to patient care, a high‐reaching future goal in medicine.ConclusionComplete data integration seems to be a long‐lasting goal, the way forward in diastology, and machine learning seems to be one of the tools suited for the challenge. With perpetual evidence that traditional approaches to complex problems may not the optimal solution, there is room for a steady and cautious, and inherently very exciting paradigm shift toward novel diagnostic tools and workflows to reach a more personalized, comprehensive, and integrated assessment of cardiac function.
Role of vitamin D in oxidative stress modulation in end‐stage renal disease patients: A double‐blind randomized clinical trial
Authors: Malekmakan Leila , Karimi Zeinab , Mansourian Afshin , Pakfetrat Maryam , Roozbeh Jamshid , Rahimi Jaberi Khojaste 
Published: June 2020

AbstractIntroductionOxidative stress is considered as important actor in uremia‐associated morbidity and mortality in hemodialysis (HD) patients. We aimed to evaluate the role of vitamin D supplementation on oxidative stress parameters in this group.MethodsThis double‐blind randomized clinical trial was conducted on HD patients who were randomly allocated into intervention (n = 40) or control groups (n = 38) for 10 weeks. Blood samples were taken before and at the end of the trial to measure serum 25‐hydroxyvitamin D (25(OH)D), malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD). Data were analyzed using SPSS, and P value <0.05 was considered to be statistically significant.FindingsOut of the 78 patients with a mean age of 44.7 ± 13.0 years, 55.1% were men. At the commencement of the study, there was no difference with respect to serum 25(OH)D levels in our groups (P = 0.575), but during the study it was significantly elevated in the intervention group (18.1 ± 9.1 vs. 31.7 ± 12.9, P < 0.0001). Serum antioxidative enzymes activity (GPx, CAT, and SOD) had significantly increased after vitamin D supplementation in the intervention group (P < 0.05). Furthermore, MDA levels was significantly reduced only in the intervention group (31.7 ± 18.0 vs. 24.7 ± 7.7, P = 0.018).DiscussionRegular consumption of vitamin D can increase the GPx, CAT, SOD, and reduce the MDA plasma levels in HD patients. Since no adverse effects of vitamin D supplementation was reported by the patients; hence, it can be prescribed for HD patients.
High genetic diversity despite drastic bottleneck in a critically endangered, long‐lived seabird, the Mascarene Petrel Pseudobulweria aterrima
Authors: Lopez Jade , Nikolic Natacha , Riethmuller Martin , Dubos Jérôme , Pinet Patrick , Souharce Patxi , Couzi François‐Xavier , Le Corre Matthieu , Jaeger Audrey , Humeau Laurence 
Published: June 2020

The Mascarene Petrel Pseudobulweria aterrima is a critically endangered seabird endemic to Reunion Island, with an extremely small population suffering several threats. Fifteen polymorphic microsatellite loci were isolated from this species to analyse genetic diversity, estimate contemporary effective population size, search for evidence of a population bottleneck and see whether results support the hypothesis that life history traits could preserve allelic diversity in small populations. Results from 22 individuals found grounded as a consequence of light pollution highlight a surprisingly high genetic diversity, an absence of inbreeding, a contemporary effective population size estimated at approximately 1211 individuals and a probable bottleneck around 10 000 generations ago. Additional studies on genetic diversity and structure from a larger number of samples are thus required to evaluate the evolutionary potential of this critically endangered species.
In vivo and in vitro antifungal effect of fungal chitosan nanocomposite edible coating against strawberry phytopathogenic fungi
Authors: Melo Natália Ferrão Castelo Branco , de Lima Marcos Antônio Barbosa , Stamford Tânia Lucia Montenegro , Galembeck André , Flores Miguel A.P. , de Campos Takaki Galba Maria , da Costa Medeiros José Alberto , Stamford‐Arnaud Thatiana Montenegro , Montenegro Stamford Thayza Christina 
Published: June 2020

SummaryThis study compared the effectiveness of fungal chitosan nanocomposite, chitosan gel and chitosan nanoparticles against strawberry phytopathogenic fungi (Botrytis cinerea; Rhizopus stolonifer and Aspergillus niger). Nanoparticles were prepared by ionic gelation method and characterised by dynamic light scattering and scanning electron microscopy. The influence of the edible coatings on fungal growth was analysed in vitro and in vivo The fungal chitosan nanoparticles presented an average size = 331.1 nm (±7.21) with a narrow size distribution (PDI = 0.377) and a zeta potential = +34 mV. The edible coating made by the nanocomposite exhibited important changes in fungal morphology, and the best control of the growth of the assayed fungal strains in artificially infected strawberries. Therefore, nanotechnology brought some benefits to the conventional chitosan gel edible coating, improving its antifungal activity and forming a new eco‐friendly coating.
China's Economy Is Not Overtaking America's
Authors: Beckley Michael 
Published: June 2020

Most scholars and pundits, along with the general public, believe that China is an economic juggernaut set to overtake America as the world's dominant power. But the conventional wisdom is wrong. The United States is several times wealthier than China; and since the global financial crisis over a decade ago, the absolute gap between the two nations has been growing by trillions of dollars each year. China's economy is big but inefficient. It produces high output at high costs. Chinese businesses suffer from chronically high production costs, and China's 1.4 billion people generate massive welfare and security burdens. The United States, by contrast, is big and efficient, producing high output at relatively low costs. American workers and businesses are seven times more productive than China's, on average; and with four times fewer people than China, the United States has much lower welfare and security costs.The conventional wisdom about China, besides being wrong, has dangerous policy implications. For starters, it creates the impression that the United States and China are locked in “Thucydides' trap” in which a rising power challenges the ruling hegemon, and the two slide into a major war. This misguided notion, widespread in both countries, is driving a spiral of hostility. Slowing this spiral requires both sides to take a clear‐eyed look at the real balance of power, which is now, and will likely remain, highly skewed in America's favor.A second danger is that an exaggerated sense of China's rise continues to fuel the current trade wars. The United States should aggressively punish unfair Chinese trade practices, but do so through a reformed WTO, regional free trade pacts, and targeted investment restrictions and economic decoupling—not with unilateral tariffs.A third danger is that exaggerated fear of China's rise and America's decline could cause the United States to back off from many of its foreign policy commitments, divesting all obligations to maintaining the global order save those linked to vital national interests. Advocates of an “America First” foreign policy are probably right that the United States could improve its relative position by ditching allies and international institutions and letting the world burn. But one of the benefits of unrivaled wealth and power is that the United States can afford to pursue absolute gains, sacrificing a bit of relative advantage to make the United States and the world better off overall. As the most secure and powerful country in history, the United States can and should do more than ceaselessly struggle for power.
Columbia Law School Roundtable on The Future Of Capitalism
Authors: Collier Paul , Mayer Colin , Schwartz Alan , Bresnahan Kristin , Pearlstein Steve 
Published: June 2020

In this discussion that took place at Columbia Law School's Millstein Center last October (and thus well before the appearance of the coronavirus), two distinguished English academics, a Pulitzer Prize‐winning journalist, and the executive chairman of a large American investment house discussed the role of corporations in addressing the crises that periodically beset the capitalist system.Sir Paul Collier opened with the comment that, although capitalism had shown itself to be the only effective system for mass human improvement in the past 10,000 years, it was now experiencing its “third serious derailment.” In each of the first two—the first in Northern England in the 1840s and the second during the Great Depression of the 1930s—capitalism was preserved in significant part by the “moral load‐bearing” performed by private companies and citizens. For capitalism to survive this third derailment, the public and private sectors must join forces to address what Collier to sees as the most formidable economic challenge: finding ways to transport urban jobs and capabilities to rural areas still reeling from two major blows—the first, a century ago to agriculture, and the second, for the past two or three decades, to large‐scale manufacturing.Collier's Oxford colleague Colin Mayer follows by calling on public companies to formulate and state a corporate social purpose that goes beyond maximizing their own long‐run shareholder values. And to encourage and support such a practice, Mayer urges the large universal owners that own large stakes in all the world's large listed companies not only to support and applaud such statements, but to find ways to ensure that companies are living up to them.Alan Schwartz, Executive Chairman of Guggenheim Partners, responds by noting that capitalism has been forced to make major adjustments throughout its history. And consistent with Collier's observations, Schwartz argues that the global economic order should have been preparing for the past 30 or 40 years for its biggest challenge: creating a global economy dynamic enough to provide jobs for some two or three billion new unskilled workers spawned by the globalization of the world economy. The American private sector, after having lost much of its efficiency and value in the 1970s, has since used continuous restructuring to produce enormous productivity gains and value. And although generally supportive of the thinking behind the Business Roundtable's recent statement, Schwartz deplores the confusion that continues to surround the message. Those corporate leaders now endorsing the pursuit of social goals are by no means asking their shareholders to accept below‐market returns on investment. In well‐run companies focused on long‐run efficiency and value, there is no inherent conflict between the interests of shareholders and the long‐run interests of other major stakeholders. In such companies, customers, employees, suppliers, and local communities all end up better served.
Sustainability at Walmart: Success over the Long Haul
Authors: Neebe Katherine 
Published: June 2020

At the core of Walmart's corporate purpose is the principle of “shared value.” The company views its mission as increasing the value of its business by helping to address important social needs. And in this article, Walmart's Senior Director of ESG discusses how the company applies the lens of shared value to three of its most significant ESG priorities: (1) economic opportunity for Walmart associates; (2) the sustainability of its supply chains, with an emphasis on the safety and livelihoods of workers; and (3) climate change, including the reduction of plastic waste.What's more, the company sees itself playing a role in transforming society through its own business practices. In reflecting on her decades of work in sustainability, the author emphasizes the value of and potential for greater stakeholder engagement and alliances of corporations with NGOs (like the World Wildlife and Environmental Defense Funds) that aim to help both lower‐income people and the environment at the same time. But the author's vision is even more ambitious: “In upholding and seeking to maximize its principle of shared value, Walmart aims not only to run a highly efficient all‐channel retail business, but to help bring about large‐scale and lasting improvements to all the social ecosystems whose functioning is part of and critical to that business.”
‘Queer’ Objects: The Art Practice as a Tool for Shared Sensory Understanding
Authors: Boulet Suzanne 
Published: June 2020

AbstractThis article is structured around three art objects I created and presented during the iJADE Conference in 2019. Through the description and manipulation of these tactile objects, which are designed in a way that allows for ease of interaction, we arrive at the concepts of familiarity and strangeness, attraction and repulsion that underpin encounters with the art object, the other and the environment. In this article we will rediscover the sense of touch as our singular access to the environment and a means of perceiving closeness. We will also examine experiments with students in an effort to understand how the art object can be significant through its affective value, and explore the concept of private and public boundaries in search of a suitable atmosphere for intimate encounters. Finally, we will ask how the art object functions as a tool that allows our distinct sensitivities to meet through a shared sensory experience, the answer to which may be found in the notions of ritual and games, in order to come to a definition of the ‘ethics of contact’.
Emotional design of multimedia learning using background images with motivational cues
Authors: Chung Sungwon , Cheon Jongpil 
Published: June 2020

AbstractEmotional design for multimedia learning can be implemented primarily using aesthetic design elements (e.g., color, shape and layout); however, we still have limited understanding on emotional design using content features visually depicting motivational cues. This study examines how valence and arousal of emotional learning content, generated by background images, in multimedia learning influenced learners' retention of factual knowledge and cognitive load, using a 2 (valence: positive, negative) × 2 (arousal: moderately low, moderately high) between‐subjects experiment. The results showed significant interaction effects, implying the positive effects of using moderately low arousing negative images on both recognition and cued‐recall test scores. Both scores were significantly lower when moderately high arousing negative images were used; however, they did not differ with increasing arousal of positive images. The emotional content did not influence germane and extraneous loads. Our findings emphasize the need for considering optimal levels of valence and arousal in emotional design.
Peroxisome proliferator‐activated receptor gamma‐ligand‐binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration
Authors: Shoaito Hussein , Chauveau Sabine , Gosseaume Camille , Bourguet William , Vigouroux Corinne , Vatier Camille , Pienkowski Catherine , Fournier Thierry , Degrelle Séverine A. 
Published: June 2020

AbstractThe transcription factor peroxisome proliferator‐activated receptor gamma (PPARG) is essential for placental development, and alterations in its expression and/or activity are associated with human placental pathologies such as pre‐eclampsia or IUGR. However, the molecular regulation of PPARG in cytotrophoblast differentiation and in the underlying mesenchyme remains poorly understood. Our main goal was to study the impact of mutations in the ligand‐binding domain (LBD) of the PPARG gene on cytotrophoblast fusion (PPARGE352Q) and on fibroblast cell migration (PPARGR262G/PPARGL319X). Our results showed that, compared to cells with reconstituted PPARGWT, transfection with PPARGE352Q led to significantly lower PPARG activity and lower restoration of trophoblast fusion. Likewise, compared to PPARGWT fibroblasts, PPARGR262G/PPARGL319X fibroblasts demonstrated significantly inhibited cell migration. In conclusion, we report that single missense or nonsense mutations in the LBD of PPARG significantly inhibit cell fusion and migration processes.