bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Coronary Obstruction and Feasibility of Coronary Access After Repeat Transcatheter Aortic Valve Replacement With the Self-Expanding Evolut Valve
Authors: Forrestal Brian J. , Case Brian C. , Yerasi Charan , Shea Corey , Torguson Rebecca , Zhang Cheng , Ben-Dor Itsik , Deksissa Teshome , Ali Syed , Satler Lowell F. , Shults Christian , Weissman Gaby , Wang John C. , Khan Jaffar M. , Waksman Ron , Rogers Toby 
Published: December 2020

Background:
The supra-annular leaflet position and tall stent frame of the self-expanding Evolut PRO or Evolut PRO+ transcatheter heart valves (THVs) may cause coronary occlusion during transcatheter aortic valve replacement (TAVR)-in-TAVR and present challenges for future coronary access. We sought to evaluate the risk of TAVR-in-TAVR with Evolut PRO or Evolut PRO+ THVs and the feasibility of future coronary access.

Methods:
The CoreValve Evolut PRO Prospective Registry (EPROMPT; NCT03423459) prospectively enrolled patients with symptomatic severe aortic stenosis to undergo TAVR using a commercially available latest generation self-expanding THV at 2 centers in the United States. Computed tomography was performed 30 days after TAVR, which we used to simulate TAVR-in-TAVR with a second Evolut PRO or Evolut PRO+ THV and evaluate for risk of coronary obstruction and feasibility of future coronary access.

Results:
Eighty-one patients enrolled with interpretable computed tomography are reported herein. Computed tomography simulation predicted sinus of Valsalva sequestration and resultant coronary obstruction during future TAVR-in-TAVR in up to 23% of patients. Computed tomography simulation predicted that the position of the pinned THV leaflets would hinder future coronary access in up to 78% of patients after TAVR-in-TAVR.

Conclusions:
Further THV design improvements and leaflet modification strategies are needed to mitigate the risk of coronary obstruction during TAVR-in-TAVR with self-expanding THVs and to facilitate future coronary access.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT03423459.
Lipid Profiles and Heart Failure Risk
Authors: Wittenbecher Clemens , Eichelmann Fabian , Toledo Estefanía , Guasch-Ferré Marta , Ruiz-Canela Miguel , Li Jun , Arós Fernando , Lee Chih-Hao , Liang Liming , Salas-Salvadó Jordi , Clish Clary B. , Schulze Matthias B. , Martínez-González Miguel Ángel , Hu Frank B. 
Published: December 2020

Rationale:
Altered lipid metabolism has been implicated in heart failure (HF) development, but no prospective studies have examined comprehensive lipidomics data and subsequent risk of HF.

Objective:
We aimed to link single lipid metabolites and lipidomics networks to the risk of developing HF.

Methods and Results:
Discovery analyses were based on 216 targeted lipids in a case-control study (331 incident HF cases and 507 controls, matched by age, sex, and study center), nested within the PREDIMED (Prevención con Dieta Mediterránea) study. Associations of single lipids were examined in conditional logistic regression models. Furthermore, lipidomics networks were linked to HF risk in a multistep workflow, including machine learning–based identification of the HF-related network clusters, and regression-based discovery of the HF-related lipid patterns within these clusters. If available, significant findings were externally validated in a subsample of the EPIC-Potsdam cohort (2414 at-risk participants, including 87 incident HF cases). After confounder-adjustments, 2 lipids were significantly associated with HF risk in both cohorts: CER (ceramide) 16:0 (relative risk [RR] per SD in PREDIMED, 1.28 [95% CI, 1.13–1.47]) and phosphatidylcholine 32_0 (RR per SD in PREDIMED, 1.23 [95% CI, 1.08–1.41]). Additionally, lipid patterns in several network clusters were associated with HF risk in PREDIMED. Adjusted for standard risk factors, an internally cross-validated score based on the significant HF-related lipids that were identified in the network analysis in PREDIMED was associated with a higher HF risk (20 lipids, RR per SD, 2.33 [95% CI, 1.93%–2.81%). Moreover, a lipid score restricted to the externally available lipids was significantly associated with HF incidence in both cohorts (6 lipids, RRs per SD, 1.30 [95% CI, 1.14–1.47] in PREDIMED, and 1.46 [95% CI, 1.17–1.82] in EPIC-Potsdam).

Conclusions:
Our study identified and validated 2 lipid metabolites and several lipidomics patterns as potential novel biomarkers of HF risk. Lipid profiling may capture preclinical molecular alterations that predispose for incident HF.

Registration:

URL:
https://www.isrctn.com/ISRCTN35739639
; Unique identifier: ISRCTN35739639.
Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine
Authors: Melhem Nada Joe , Chajadine Mouna , Gomez Ingrid , Howangyin Kiave-Yune , Bouvet Marion , Knosp Camille , Sun Yanyi , Rouanet Marie , Laurans Ludivine , Cazorla Olivier , Lemitre Mathilde , Vilar José , Mallat Ziad , Tedgui Alain , Ait-Oufella Hafid , Hulot Jean-Sébastien , Callebert Jacques , Launay Jean-Marie , Fauconnier Jeremy , Silvestre Jean-Sébastien , Taleb Soraya 
Published: December 2020

Background:
Ischemic cardiovascular diseases, particularly acute myocardial infarction (MI), is one of the leading causes of mortality worldwide. Indoleamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of L-tryptophan metabolism, and emerges as an important regulator of many pathological conditions. We hypothesized that IDO could play a key role to locally regulate cardiac homeostasis after MI.

Methods:
Cardiac repair was analyzed in mice harboring specific endothelial or smooth muscle cells or cardiomyocyte or myeloid cell deficiency of IDO and challenged with acute myocardial infarction.

Results:
We show that kynurenine generation through IDO is markedly induced after MI in mice. Total genetic deletion or pharmacological inhibition of IDO limits cardiac injury and cardiac dysfunction after MI. Distinct loss of function of IDO in smooth muscle cells, inflammatory cells, or cardiomyocytes does not affect cardiac function and remodeling in infarcted mice. In sharp contrast, mice harboring endothelial cell–specific deletion of IDO show an improvement of cardiac function as well as cardiomyocyte contractility and reduction in adverse ventricular remodeling. In vivo kynurenine supplementation in IDO-deficient mice abrogates the protective effects of IDO deletion. Kynurenine precipitates cardiomyocyte apoptosis through reactive oxygen species production in an aryl hydrocarbon receptor–dependent mechanism.

Conclusions:
These data suggest that IDO could constitute a new therapeutic target during acute MI.
Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation
Authors: Pengo Martino F. , Faini Andrea , Grote Ludger , Ludka Ondrej , Joppa Pavol , Pataka Athanasia , Dogas Zoran , Mihaicuta Stefan , Hein Holger , Anttalainen Ulla , Ryan Silke , Lombardi Carolina , Parati Gianfranco ,   on behalf of the ESADA Working Group
Published: December 2020

Background and Purpose:
An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF.

Methods:

We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Sp
o
2
and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA
2
DS
2
-VASc score.

Results:

From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA
2
DS
2
-VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Sp
o
2
81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively,
P
<0.05).

Conclusions:
These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.
Severity of Nonalcoholic Fatty Liver Disease and Risk of Future Ischemic Stroke Events
Authors: Xu Jie , Dai Liye , Zhang Yijun , Wang Anxin , Li Hao , Wang Yilong , Meng Xia , Wu Shouling , Wang Yongjun 
Published: December 2020

Background and Purpose:
We assessed prospectively whether nonalcoholic fatty liver disease (NAFLD) and its severity predict future ischemic stroke (IS) events in a community-based cohort.

Methods:
From the Kailuan study, participants free of history of stroke, cancer, or myocardial infarction were enrolled after excluding alcohol abuse and other liver diseases. NAFLD was evaluated through ultrasonography. Participants with NAFLD were further stratified into mild, moderate, and severe groups. The outcome was the first occurrence of IS. The secondary outcomes included myocardial infarction and combined vascular events. We used Cox proportional hazards models to estimate hazard ratios and 95% CIs of incident IS according to presence and severity of NAFLD, adjusting for age, sex, physical activity, body mass index, smoker, history of hypertension, diabetes, hypercholesterolemia, lipid-lowering medication, HDL (high-density lipoprotein), triglyceride, hsCRP (high-sensitivity C-reactive protein), and fasting blood glucose.

Results:
During a median of 10.34 years of follow-up, we documented 3490 incident stroke cases among 79 905 participants. NAFLD was found in 24 874 (31.18%) participants. Relative to participants without NAFLD at the baseline, those with NAFLD had a 16% higher risk (95% CI, 1.07–1.26) of developing ischemic stroke, after adjusted for confounding variables. The hazard ratios for patients with mild, moderate, and severe NAFLD were 1.15 (95% CI, 1.05–1.25), 1.19 (95% CI, 1.06–1.34), and 1.21 (95% CI, 1.08–1.50), respectively.

Conclusions:
The severity of NAFLD is associated with a higher risk of future ischemic stroke events.
SEEC: Photography at the Speed of Light
Authors: de Dios Rodríguez Enar , Klopfer Brannon B. , Haslinger Philipp , Juffmann Thomas 
Published: December 2020

Abstract
SEEC photography is a project at the intersection of art and science. It uses modern technology to record the motion of light, to see c, that is, the universal physical constant for the speed of light and the inspiration for the project name SEEC. In order to familiarize the general public with this physical phenomenon, SEEC records light moving across familiar objects, with visual scenes paying homage to iconic images from the history of photography. Exposure times shorter than 0.3 nanoseconds allow the authors to capture light (Greek: phos) in the process of writing (Greek: graphein) an image.
Sonifying Data: For the Art, for the Science and for What Lies Between
Authors: Ballora Mark 
Published: December 2020

Abstract
To explore intersections of art and science is to acknowledge that there are differing degrees of knowing, understanding and experience. This article describes three data sonification projects the author worked on using datasets from researchers. The sonifications were created to be used within scientifically informed musical performances by Grateful Dead percussionist Mickey Hart. The projects posed particular design challenges for the author as he sought to create “data art” that had “sonification integrity.”
Memory Machines: Infrastructural Performance as an Art Method
Authors: Bhowmik Samir , Parikka Jussi 
Published: December 2020

AbstractThrough the Memory Machines performance tour conducted in a public library, the authors analyze multisensory methods including immersive performance and walking tours as probes into cultural infrastructures. Combining discussions of media theory and artistic practice, including collaboration with the 00100 Ensemble, the authors present infrastructural performance as an art method for creative infrastructural research.
Crypto Art: A Decentralized View
Authors: Franceschet Massimo , Colavizza Giovanni , Smith T’ai , Finucane Blake , Ostachowski Martin Lukas , Scalet Sergio , Perkins Jonathan , Morgan James , Hernández Sebastián 
Published: December 2020

Abstract
Crypto art is limited-edition digital art, cryptographically registered with a token on a blockchain. Tokens represent a transparent, auditable origin and provenance for a piece of digital art. Blockchain technology allows tokens to be held and securely traded without the involvement of third parties. Crypto art draws its origins from conceptual art—sharing the immaterial and distributive nature of artworks, the tight blending of artworks with currency and the rejection of conventional art markets and institutions. The authors propose a collection of viewpoints on crypto art from different actors within the system: artists, collectors, gallerists, art historians and data scientists. A set of emerging themes and open challenges surfaces.
A Neural Network Looks at Leonardo’s(?) Salvator
Mundi
Authors: Frank Steven J. , Frank Andrea M. 
Published: December 2020

Abstract
The authors use convolutional neural networks (CNNs) to analyze authorship questions surrounding the works of Leonardo da Vinci—in particular, Salvator Mundi, the world’s most expensive painting and among the most controversial. Trained on the works of an artist under study and visually comparable works of other artists, the authors’ system can identify likely forgeries and shed light on attribution controversies. Leonardo’s few extant paintings test the limits of the system and require corroborative techniques of testing and analysis.
Is There a Place in Human Consciousness Where Surveillance Cannot Go?Noor: A Brain Opera
Authors: Pearlman Ellen 
Published: December 2020

AbstractNoor: A Brain Opera is the first fully interactive, immersive brainwave opera, in which a performer wearing a wireless EEG brainwave headset touches, gazes and walks around audience members in a 360° theater while a story is narrated. Her measured emotional states trigger videos, sound and a prerecorded libretto as her emotions are displayed as live time-colored bubbles. The opera rhetorically asks: “Is there a place in human consciousness where surveillance cannot go?” This article discusses the rationale and implementation of the brainwave opera.
Tracking the Loving Gaze
Authors: Stylianou-Lambert Theopisti , Panayides Omiros 
Published: December 2020

Abstract
Tracking the Loving Gaze is a futile attempt to follow, map and capture the way cherished personal photographs are viewed. The authors asked 30 survey subjects to use an eye tracker while looking at a preselected photograph that held a special meaning for them. The raw visual data from this process—heat maps, focus maps and scan paths—became the foundation of a body of work that includes darkroom prints, short videos and a limited-edition artist book. Apart from exploring the invisible viewing processes of personal photography, this article introduces the concepts of the detached and the invested viewer as well as the corresponding concepts of the cold and the loving gaze.
The Missing Female Homunculus
Authors: Wright Haven , Foerder Preston 
Published: December 2020

Abstract
The somatosensory homunculus shows an exaggerated human figure that illustrates the proportion of the brain devoted to the sense of touch in each part of the body. Originally based on Wilder Penfield’s brain mapping, it has been presented as a drawing of a human figure along the somatosensory cortex, an independent human figure and a sculpted figure. Until recently, these homunculi have been male due to the lack of information on the female somatosensory cortex. A few female homunculi have been drawn. Based on more current brain research, the authors present, to their knowledge, the first sculpted 3D female somatosensory homunculus.
The Lexical Impact of Hebrew in the Judeo-Italian of Medieval and Renaissance Siddur Translations
Authors: Ryzhik Michael 
Published: December 2020

Abstract
General traits of the Hebrew components of Judeo-Italian Siddur translations are analyzed. The most interesting cases are those where the same Hebrew component is used differently in different contexts: (1) the same Hebrew word remains untranslated in the title and is translated by the Romance lexical unit in the text of the prayer (שבת/sabbeto; כהן/sacerdote); (2) the same Hebrew word in the divine (mystic) sense remains untranslated, while in the secular sense it is translated as the Italian word (צבאות/osti); (3) one Hebrew component lexical unit translates another Hebrew word (אִשִּׁים > קרבנות ;נשך > רבית ;חולק < טענה); (4) one form of the Hebrew word is translated by another form of the same word (עולמות > עולמים). The two latter categories are especially instructive in studying the Hebrew component of spoken and written Judeo-Italian.
Reply to “Comments on ‘How Much Does the Upward Advection of the Supergradient Component of Boundary Layer Wind Contribute to Tropical Cyclone Intensification and Maximum Intensity?’”
Authors: Li Yuanlong , Wang Yuqing , Lin Yanluan 
Published: December 2020

AbstractThis is a reply to the comments by Smith et al. (2020, hereafter SGM20) on the work of Li et al. (2020, hereafter LWL20) recently published in the Journal of the Atmospheric Sciences. All the comments and concerns by SGM20 have been well addressed or clarified. We think that most of the comments by SGM20 are not in line with the intention of LWL20 and provide one-sided and thus little scientifically meaningful arguments. Regarding the comment on the adequacy of the methodology adopted in LWL20, we believe that the design of the thought (sensitivity) experiment is adequate to address the scientific issue under debate and helps quantify the contribution by the upward advection of the supergradient component of boundary layer wind to tropical cyclone intensification, which is shown to be very marginal. Note that we are open to accept any alternative, better methods to be used to further address this scientific issue.
Survey of patient perception of pre-analytical requirements for blood testing in the UK and RoI
Authors: Hepburn S , Jankute M , Cornes MP , Rios N Rico , Stretton A , Costelloe SJ 
Published: December 2020

Background A patient survey developed by the Pre-Analytical Phase Special Interest Group of the Association for Clinical Biochemistry and Laboratory Medicine (ACB-PA-SIG) was conducted during November and December 2019. The survey aimed to determine the quality of information provided to patients in preparation for their blood test(s). In addition, the ACB-PA-SIG provide a number of recommendations, which, if adopted, may yield higher quality test results and improve patient management. Methods The survey was distributed at phlebotomy suites in two Hospitals: Ipswich Hospital (United Kingdom [UK]), and Cork University Hospital (Republic of Ireland [RoI]). Results Overall, 235 survey responses were received from the two sites. A total of 103 respondents received no information about preparing for their blood test and 92 had been told they did not need to fast. None of the patients surveyed had been instructed to fast for 12 h. Twenty-two patients had been told to avoid certain foods, drinks or medication, 14 were told to avoid strenuous activity and 41 respondents had been informed of the need to avoid alcohol/smoking prior to their blood test. Overall, only approximately 78 felt well informed about the blood taking process. Conclusions Based on the results of this survey, the ACB-PA-SIG conclude that: (1) clinicians should provide clear written information to patients regarding pre-analytical requirements; and (2) effective communication between laboratories and General Practitioners is required to disseminate information. In this paper, the ACB-PA-SIG provide a list of pre-analytical recommendations to standardize and improve practice across the UK and RoI.
Home-based exercise monitored with telehealth is feasible and acceptable compared to centre-based exercise in Parkinson’s disease: A randomised pilot study
Authors: Flynn Allyson , Preston Elisabeth , Dennis Sarah , Canning Colleen G , Allen Natalie E 
Published: December 2020

Objectives: To investigate the feasibility and acceptability of a home-based exercise program monitored using telehealth for people with Parkinson’s disease. Design: Pilot randomised control trial. Setting: University physiotherapy clinic, participants’ homes. Participants: Forty people with mild to moderate Parkinson’s disease, mean age 72 (6.9). Intervention: In Block 1 (5 weeks) all participants completed predominantly centre-based exercise plus a self-management program. Participants were then randomised to continue the centre-based exercise ( n = 20) or to a home-based program with telehealth ( n = 20) for Block 2 (5 weeks). The exercises targeted balance and gait. Outcomes: The primary outcomes were the feasibility and acceptability of the intervention. Secondary outcomes were balance, gait speed and freezing of gait. Results: Adherence was high in Block 1 (93%), and Block 2 (centre-based group = 93%, home-based group = 84%). In Block 2, the physiotherapist spent 6.4 hours providing telehealth to the home-based group (mean 10 (4) minutes per participant) and 32.5 hours delivering the centre-based exercise classes (98 minutes per participant). Participants reported that exercise was helpful, they could follow the home program and they would recommend exercising at home or in a group. However, exercising at home was less satisfying and there was a mixed response to the acceptability of the self-management program. There was no difference between groups in any of the secondary outcome measures (preferred walking speed mean difference −0.04 (95% CI: −0.12 to 0.05). Conclusion: Home-based exercise monitored using telehealth for people with Parkinson’s disease is feasible and acceptable.
Sex-specific sensitivity to methamphetamine-induced schizophrenia-relevant behaviours in neuregulin 1 type III overexpressing mice
Authors: Chesworth Rose , Rosa-Porto Rossana , Yao Sofia , Karl Tim 
Published: December 2020

Background: Gene–environment interactions contribute to schizophrenia aetiology. Neuregulin 1 is a well-established genetic risk factor for schizophrenia, and elevated expression of type III neuregulin 1 mRNA in the dorsolateral prefrontal cortex is observed in patients with a core risk haplotype. A mouse model of type III Nrg1 overexpression ( Nrg1 III tg) possesses face and construct validity for schizophrenia; however, the sensitivity of these transgenic mice to environmental risk factors relevant to schizophrenia is unknown. Aims: To determine sensitivity of Nrg1 III tg mice to the psychostimulant methamphetamine (METH) in schizophrenia and addiction-relevant behavioural tests. Methods: We examined behavioural responses of adult male and female Nrg1 III tg mice METH (1–3 mg/kg) in schizophrenia-relevant paradigms (drug-induced locomotion, sensorimotor gating) and drug reward (conditioned place preference). Results: Male Nrg1 III tg mice were less sensitive to METH-induced stereotypies, yet showed a greater negative impact of METH on prepulse inhibition compared with wild type-like males. In contrast, female Nrg1 III tg mice were less sensitive to METH-induced locomotion than wild type-like females, while sensorimotor gating was similarly impaired by METH between the genotypes. There were no genotype differences for METH reward, or anxiety-like and exploratory behaviours. Conclusions: These results indicate that overexpression of Nrg1 type III modulates schizophrenia-relevant behaviours, and may help to explain increased sensitivity to the psychoactive effects of METH in patients with schizophrenia.