bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of the Mobile ‘Blood Pressure Management Application’ on Hypertension Self-Management Enhancement: A Randomised Controlled Trial
Authors: Bozorgi Ali , Hosseini Hamed , Eftekhar Hassan , Majdzadeh Reza , Yoonessi Ali , Ramezankhani Ali , Mansouri Mehdi , Ashoorkhani Mahnaz 
Published: October 2019

Abstract
Background : Self-management of blood pressure is of great significance given the increasing incidence of hypertension and associated disabilities. With the increased use of mobile health in medicine, the present study evaluated the effect of the self-management application on patient adherence to hypertension treatment.
Methods : This clinical trial was performed on 120 hypertensive patients who were provided with a mobile intervention for 8 weeks and followed-up to 24 th weeks. Data on the primary outcome (adherence to treatment) and secondary outcomes (adherence to the DASH diet, regular monitoring of blood pressure, and physical activity) were collected using a questionnaire and a mobile application, respectively. The inter-group change difference over time was analyzed using repeated measures ANOVA (General Linear Model).
Results : The treatment adherence score increased by an average of 5.9 (95%CI: 5.0-6.7) in the intervention group compared to the control group. Scores of adherence to the low-fat and low-salt diet plans were 1.7 (95%CI: 1.3-2.1) and 1.5 (95%CI: 1.2-1.9), respectively. Moreover, moderate physical activity increased to 100.0 minutes (95%CI: 61.7-138.3) per week in the intervention group.
Conclusion: The treatment and control of blood pressure require a multifaceted approach given its complexity and multifactorial nature. Considering the widespread use of smartphones , mhealth interventions can be effective in self-management and better patient adherence to treatments. Our results showed that this application can be used as a successful tool for hypertension self-management in patients attending public hospitals in developing countries.
Trial registration: This study was registered in the Iran Randomized Clinical Trial Center under the number IRCT2015111712211N2 on 1 January 2016.
Comparison of Soil‐Test Extractants for Potassium, Calcium, Magnesium, Sulfur, and Micronutrients in Idaho Soils
Authors: Rogers C. W. , Dari B. , Schroeder K. L. 
Published: October 2019

Core IdeasMultinutrient extractants were correlated to standard tests on alkaline calcareous soilsFor the tested nutrients Mehlich‐3 generally extracted greater and H3A less than the common tests used in the Western United StatesMehlich‐3 extracted large amounts of Ca when inorganic‐C as CaCO3was greater than 3.3 g kg−1resulting in poor correlation with the ammonium acetate testSoil fertility and nutrient management programs across Idaho and the western United States should consider the effective comparison of various extractants for nutrient analyses. Common extractants for K, Ca, Mg, S, and micronutrients (Zn, Cu, Mn, Fe, B, Na) vary (e.g., ammonium acetate [AA], Olsen, etc.). The desire to develop effective correlation equations among common tests in the region and those of multinutrient extractants used or proposed in other geographical regions (i.e., Mehlich‐3 [M‐3] and Haney, Haney, Hossner, Arnold [H3A]) has increased due to the interest in nutrient management planning and in relation to soil health measurements. To investigate these multinutrient tests, 46 primarily alkaline soils were sampled from the 0‐ to 30‐cm depth in agricultural fields in Idaho. Linear regressions between AA and Olsen K and both M‐3 and H3A resulted in a significant positive fit (R2= 0.69–0.90). Notable issues with increased Ca concentrations occurred in soils with large amounts of inorganic C. Removal of these samples improved the relationship between standard and multinutrient soil tests. Specific micronutrient regressions were problematic when both alkaline and acidic soils were analyzed but improved when separated. Mehlich‐3 and H3A extractants were generally well correlated, with the exceptions noted above, to common extractants used in western soils. Thus, this research provides specific correlation equations that could be used for comparison among tests as well as provides evidence of the potential suitability of multinutrient extractants in the region.
Linking water quality monitoring and climate-resilient water safety planning in two urban drinking water utilities in Ethiopia
Authors: van den Berg Harold , Rickert Bettina , Ibrahim Seada , Bekure Kasa , Gichile Hailu , Girma Seble , Azezew Altaseb , Belayneh Tadesse Zegeye , Tadesse Solomon , Teferi Zeleke , Abera Firehiwot , Girma Samson , Legesse Tesfaye , Truneh Daniel , Lynch Gretta , Janse Ingmar , de Roda Husman Ana Maria 
Published: October 2019

Abstract
Unsafe drinking water is a recognized health threat in Ethiopia, and climate change, rapid population growth, urbanization and agricultural practices put intense pressure on availability and quality of water. Climate change-related health problems due to floods and waterborne diseases are increasing. With increasing insight into impacts of climate change and urbanization on water availability and quality and of required adaptations, a shift towards climate-resilient water safety planning was introduced into an Ethiopian strategy and guidance document to guarantee safe drinking water. Climate-resilient water safety planning was implemented in the urban water supplies of Addis Ababa and Adama, providing drinking water to 5 million and 500,000 people, respectively. Based on the risks identified with climate-resilient water safety planning, water quality monitoring can be optimized by prioritizing parameters and events which pose a higher risk for contaminating the drinking water. Water quality monitoring was improved at both drinking water utilities and at the Public Health Institute to provide relevant data used as input for climate-resilient water safety planning. By continuously linking water quality monitoring and climate-resilient water safety planning, utilization of information was optimized, and both approaches benefit from linking these activities.
Degradation study of tris(2-butoxyethyl) phosphate with TiO2 immobilized on aluminum meshes employing artificial neural networks
Authors: Aquino Ramon Vinícius Santos de , Barbosa Ada Azevedo , Carvalho Rafaela Ferreira de , Silva Marina Gomes , Nascimento Júnior Welenilton José do , Silva Túlio Diego da , Silva Josivan Pedro , Rossiter Sá da Rocha Otidene 
Published: October 2019

Abstract
This work presents the study of tris(2-butoxyethyl) phosphate advanced oxidation in TiO2-containing systems. Titania was immobilized on aluminum surfaces from recyclable materials and the results were compared with the suspension system. The initial concentration of photocatalyst and the oxidizing agent was optimized in a 23 experimental design and a kinetic study of the reactions was performed in the selected conditions. The experimental data were fitted to the pseudo-first-order model (rate constants estimated at 0.0129 ± 0.0009 and 0.0079 ± 0.0006 min−1 for the systems with TiO2 in suspension and immobilized, respectively). Artificial neural networks were also employed to model the experimental data and they presented correlation coefficients superior to 0.98 in all the training operations. After five cycles of degradation, the TiO2–aluminum meshes exhibited a very low decrease in photocatalytic activity (inferior to 2%). Acute phytotoxicity assays demonstrated that the byproducts of the oxidation of TBEP molecules are less toxic than the raw samples regarding lettuce seeds. For both TiO2 systems, COD decreased considerably as a consequence of the degradation. The immobilized TiO2 system achieved similar degradation rates when compared with the suspension system.
An Overview of Prospective Drugs for Type 1 and Type 2 Diabetes
Authors: Wu Ping , Liu Zhenyu , Jiang Xiaohong , Fang Hao 
Published: October 2019

Aims:The aim of this study is to provide an overview of several emerging anti-diabetic molecules.Background:Diabetes is a complex metabolic disorder involving the dysregulation of glucose homeostasis at various levels. Insulin, which is produced by β-pancreatic cells, is a chief regulator of glucose metabolism, regulating its consumption within cells, which leads to energy generation or storage as glycogen. Abnormally low insulin secretion from β-cells, insulin insensitivity, and insulin tolerance lead to higher plasma glucose levels, resulting in metabolic complications. The last century has witnessed extraordinary efforts by the scientific community to develop anti-diabetic drugs, and these efforts have resulted in the discovery of exogenous insulin and various classes of oral anti-diabetic drugs.Objective:Despite these exhaustive anti-diabetic pharmaceutical and therapeutic efforts, long-term glycemic control, hypoglycemic crisis, safety issues, large-scale economic burden and side effects remain the core problems.Method:The last decade has witnessed the development of various new classes of anti-diabetic drugs with different pharmacokinetic and pharmacodynamic profiles. Details of their FDA approvals and advantages/disadvantages are summarized in this review.Results:The salient features of insulin degludec, sodium-glucose co-transporter 2 inhibitors, glucokinase activators, fibroblast growth factor 21 receptor agonists, and GLP-1 agonists are discussed.Conclusion :In the future, these new anti-diabetic drugs may have broad clinical applicability. Additional multicenter clinical studies on these new drugs should be conducted.
Strategies Targeting Soluble β-Amyloid Oligomers and their Application to Early Diagnosis of Alzheimer’s Disease
Authors: Zeng Fantian , Li Yuyan , Xu Yungen , Yang Jian , Liu Zhengshi , Li Xiaofang , Ren Longfei 
Published: October 2019

Background:
Alzheimer’s Disease (AD) is the most common neurodegenerative disorder,
and it is still incurable. Early diagnosis and intervention are crucial for delaying the onset and progression
of the disease. Mounting evidence indicates that the neurotoxic effects might be attributed to Soluble
β-Amyloid Oligomers (SAβO). The SAβO are believed to be neurotoxic peptides more predominant
than Aβ plaques in the early stage, and their key role in AD is self-evident. Unfortunately, identification
of SAβO proves to be difficult due to their heterogeneous and transient nature. In spite of many obstacles,
multiple techniques have recently been developed to target SAβO effectively. This review focuses
on the recent progress in the approaches towards SAβO detection in order to shed some light on the future
development of SAβO assays.

Methods :
Literatures were obtained from the following libraries: Web of Science, PubMed, EPO, SIPO,
USPTO. Articles were critically reviewed based on their titles, abstracts, and contents.

Results:
A total of 85 papers are referenced in the review. Results are divided into three categories
based on the types of detection methods: small molecule fluorescence probes, oligomer-specific antibodies
and electrochemical biosensors. Finally, the improvements and challenges of these approaches applied
in the early diagnosis of AD were discussed.

Conclusion:
This review article covers three kinds of strategies that could be translated into clinic practice
and lead to earlier diagnosis and therapeutic interventions of AD.
Chirality of Central Nervous System (CNS) Acting Drugs: A Formidable Therapeutic Hurdle Against CNS Diseases
Authors: Saganuwan Saganuwan Alhaji 
Published: October 2019

Background:Over fifty percent of drugs being used clinically are chiral and 90% of them are racemates. Unfortunately, they have both adverse and beneficial effects on body systems.Methods:Because of the erratic effects of chiral compounds on body functional systems, literature search was carried out with a view to identify CNS chiral drugs, their clinical advantages and disadvantages, unique physicochemical properties and structural modifications into safer drugs.Results:Findings have shown that majority of CNS and non-CNS acting drugs have chiral functional groups that may occur as either dextrorotatory (clockwise) or levorotatory (anticlockwise) or racemates which are inert. Sometimes, the enantiomers (optical isomers) could undergo keto-enol tautomerism, appearing in either acidic or basic or inert form. Chiral CNS acting drugs have agonistic and antagonistic effects, clinical advantages, disadvantages, and special clinical applications, possible modifications for better therapeutic effects and possible synthesis of more potent drugs from racemates. Clockwise chirality may be more effective and safer than the drugs with anticlockwise chirality. When chiral drugs are in racemate state they become inert and may be safer than when they are single. Also, diastereoisomers may be more dangerous than stereoisomers.Conclusion:Therefore, chiral compounds should be adequately studied in lab rodents and primates, and their mechanisms of actions should be comprehensively understood before being used in clinical setting. Since many of them are toxic, their use should be based on principle of individualized medicine. Their molecular weights, functional groups, metabolites, polymers and stereoisomers could be valuable tools for their modifications.
Guanine Content of MicroRNAs is Associated with their Tumor- Suppressive and Oncogenic Roles in Lung and Breast Cancers
Authors: Cohen Amit , Burgos-Aceves Mario Alberto , Smith Yoav 
Published: October 2019

Background:
microRNAs (miRNAs, miRs) are small noncoding RNAs that negatively
regulate gene expression at the post-transcriptional level and fine-tune gene functions. Global repression
of miRNAs expression in different types of human tumors, after exposure to cigarette smoke, or
to the hormone estrogen, have been shown to be associated with guanine (G) enrichment in the terminal
Loops (TLs) of their precursors.

Methods:
We integrated the G content of miRNA mature forms and precursor miRNA TLs with their
described function in the literature, using the PubMed database. Gene Ontology term analysis was
used to describe the pathways in which the G-enriched miRNA targets are involved.

Results :
Herein, we show an association between the relative G enrichment of precursor miRNAs’
TLs and their tendency to act as tumor suppressor miRs in human lung and breast cancers. Another
association was observed between the high G content of the miRNAs 5-mature forms and their tendency
to act as oncomiRs.

Conclusion:
: The results support previous findings showing that the G sequence content is an important
feature determining miRNA expression and function, and opens the way for future cancer investigations
in this direction.
The effect of guided inquiry learning methods on learning outcomes in terms of learning motivation of fourth grade students the theme of my ideals
Authors: Hasanah Nikmatun 
Published: October 2019

Abstrak: This study aims to describe the effect of guided inquiry learning methods on learning outcomes in terms of learning motivation of fourth grade students on the theme of my dreams. This research is a quasi-experimental study with the design of a non-equivalent control group. The population in this study was all of the fourth grade of SDN Jember Lor 02 in the 2018/2019 school year which consisted of two classes namely IVA and IVB. The experimental class and control class samples were determined by drawing, so the experimental classes IVA and IVB control classes were obtained. Data was collected using tests and questionnaires. The validity of the test instruments and questionnaires was obtained by using the product moment correlation formula, while the reliability test was obtained using the Cronbach Alpha formula assisted by SPSS version 16. Data were analyzed using Analysis of Variance (ANOVA) type two way analysis of variance with a significance level of 5%. The results showed that: 1) there was a positive and significant influence of the use of guided inquiry learning methods on student learning outcomes of high motivation groups, and 2) there was a positive and significant effect of the use of guided inquiry learning methods on low motivation group student learning outcomes. Pengaruh metode pembelajaran inkuiri terbimbing terhadap hasil belajar ditinjau dari motivasi belajar siswa kelas iv tema cita-citakuAbstrak: Penelitian ini bertujuan untuk mendeskripsikan pengaruh metode pembelajaran inkuiri terbimbing terhadap hasil belajar ditinjau dari motivasi belajar siswa kelas IV dengan tema cita-citaku. Penelitian ini merupakan penelitian quasi experiment dengan desain non-equivalent control group. Populasi dalam penelitian ini adalah seluruh kelas IV SDN Jember Lor 02 pada tahun pelajaran 2018/2019 yang terdiri dari dua kelas yaitu kelas IVA dan IVB. Sampel kelas eksperimen dan kelas kontrol ditentukan melalui pengundian, sehingga diperoleh kelas eksperimen IVA dan kelas kontrol IVB. Data dikumpulkan menggunakan tes dan angket. Validitas instrumen tes dan angket diperoleh dengan menggunakan rumus korelasi product moment, sedangkan uji reliabilitasnya diperoleh dengan menggunakan rumus Alpha Cronbach berbantuan SPSS versi 16. Data dianalisis menggunakan uji ANOVA (Analysis of Varians) jenis two way analysis of varians dengan taraf signifikansi 5%. Hasil penelitian menunjukkan bahwa: 1) terdapat pengaruh positif dan signifikan penggunaan metode pembelajaran inkuiri terbimbing terhadap hasil belajar siswa kelompok motivasi tinggi, dan 2) terdapat pengaruh positif dan signifikan penggunaan metode pembelajaran inkuiri terbimbing terhadap hasil belajar siswa kelompok motivasi rendah.
A Patient Decision Aid App for Patients With Chronic Kidney Disease: Questionnaire Study
Authors: Therkildsen Signe Bülow , Hansen Linda Houlind , Jensen Laura Emilie Dinesen , Finderup Jeanette 
Published: October 2019

Background
The Dialysis Guide (DG) is a patient decision aid (PDA) available as an app and developed for mobile phones for patients with chronic kidney disease facing the decision about dialysis modality.

Objective
The aim of this study was to uncover the applicability of the DG as a PDA.

Methods
The respondents completed a questionnaire before and after using the DG. The respondents' decisional conflicts were examined using the Decisional Conflict Scale, and the usability of the app was examined using the System Usability Scale (SUS). The change in decisional conflict was determined with a paired t test.

Results
A total of 22 respondents participated and their mean age was 65.05 years; 20 out of 22 (90%) had attended a patient school for kidney disease, and 13 out of 22 (59%) had participated in a conversation about dialysis choice with a health professional. After using the DG, the respondents' decisional conflicts were reduced, though the reduction was not statistically significant (P=.49). The mean SUS score was 66.82 (SD 14.54), corresponding to low usability.

Conclusions
The DG did not significantly reduce decisional conflict, though the results indicate that it helped the respondents decide on dialysis modality. Attending a patient school and having a conversation about dialysis modality choice with a health professional is assumed to have had an impact on the decisional conflict before using the DG. The usability of the DG was not found to be sufficient, which might be caused by the respondents’ average age. Thus, the applicability of the DG cannot be definitively determined.
Effect of Brief Biofeedback via a Smartphone App on Stress Recovery: Randomized Experimental Study
Authors: Hunter John F , Olah Meryl S , Williams Allison L , Parks Acacia C , Pressman Sarah D 
Published: October 2019

Background
Smartphones are often vilified for negatively influencing well-being and contributing to stress. However, these devices may, in fact, be useful in times of stress and, in particular, aid in stress recovery. Mobile apps that deliver evidence-based techniques for stress reduction, such as heart rate variability biofeedback (HRVB) training, hold promise as convenient, accessible, and effective stress-reducing tools. Numerous mobile health apps that may potentially aid in stress recovery are available, but very few have demonstrated that they can influence health-related physiological stress parameters (eg, salivary biomarkers of stress). The ability to recover swiftly from stress and reduce physiological arousal is particularly important for long-term health, and thus, it is imperative that evidence is provided to demonstrate the effectiveness of stress-reducing mobile health apps in this context.

Objective
The purpose of this research was to investigate the physiological and psychological effects of using a smartphone app for HRVB training following a stressful experience. The efficacy of the gamified Breather component of the Happify mobile health app was examined in an experimental setting.

Methods
In this study, participants (N=140) underwent a laboratory stressor and were randomly assigned to recover in one of three ways: with no phone present, with a phone present, with the HRBV game. Those in the no phone condition had no access to their phone. Those in the phone present condition had their phone but did not use it. Those in the HRVB game condition used the serious game Breather on the Happify app. Stress recovery was assessed via repeated measures of salivary alpha amylase, cortisol, and self-reported acute stress (on a 1-100 scale).

Results
Participants in the HRVB game condition had significantly lower levels of salivary alpha amylase during recovery than participants in the other conditions (F2,133=3.78, P=.03). There were no significant differences among the conditions during recovery for salivary cortisol levels or self-reported stress.

Conclusions
These results show that engaging in a brief HRVB training session on a smartphone reduces levels of salivary alpha amylase following a stressful experience, providing preliminary evidence for the effectiveness of Breather in improving physiological stress recovery. Given the known ties between stress recovery and future well-being, this study provides a possible mechanism by which gamified biofeedback apps may lead to better health.
ANTI-ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF PIPER BETLE LEAF ON EXPERIMENTAL ANIMALS
Authors: URMISTHA SARKAR  , ANKIT SAHA  , MRITYUNJOY MAJUMDAR  
Published: October 2019

Objective: The main objective of this study is to establish the anti-ulcer activity of hydroalcoholic extract of Piper betle leaf on experimental animals based on previously existing aspects such as antioxidant, antihistaminic, and antimicrobial properties of P. betle leaf.
Methods: The leaves were collected, shed dried, and extracted by the Soxhlet apparatus using 70% ethanol. The anti-ulcer activity of the extract was evaluated in albino Wistar rats employing pyloric ligation and stress-induced antiulcer models. Ranitidine was served as a standard drug in both the models. The significance of activity was assessed using a one-way analysis of variance followed by Dunnett’s post-parametric test.
Results: In the pyloric ligation model, the untreated control has shown 4.3 mEq/l of acidity, whereas the ranitidine-treated standard group shown 2 mEq/l and P. betle has shown 2.5 mEq/l acidity, respectively. In the stress-induced antiulcer model, the activity was more prominent, in the untreated control, there was 26 number of sores present, whereas the standard group showed only one number of ulcer sore, and in the P. betle treated group, there was four number of ulcer sores present.
Conclusion: In the present study, P. betle exhibited potent antiulcer potential while compared with the untreated control and the activity is comparable with standard ranitidine. From the above findings, it can correlate the use of betel leaf as a digesting or gastroprotective agent.