bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Content validity, construct validity and magnitude of change for the eight-item HAKIR questionnaire - a patient reported outcome in the Swedish national healthcare quality registry for hand surgery.
Authors: Carlsson Ingela K , Ekstrand Elisabeth , Åström Mikael , Stihl Kerstin , Arner Marianne 
Published: December 2019

Abstract
Background The Swedish National Healthcare Quality registry for hand surgery, called HAKIR, includes collection of patient-reported outcome measures (PROMs) for all operations performed at the specialist departments of hand surgery. A prerequisite for PROMs is that the collection of data is based on psychometrically sound outcome instruments. This study therefore aims to evaluate content and construct validity, floor and ceiling effects, data completeness and magnitude of change over time for the eight-item HAKIR questionnaire.Methods Content validity was investigated by patients, an expert group and literature review. Construct validity was investigated through predefined hypotheses and correlation statistics between single-item questions and QuickDASH. Floor and ceiling effect and data completeness was analysed on 13197 preoperative, 10702 three months and 9986 twelve months postoperative questionnaires. Changes in scores for single-items between pre- and 3 and 12 months follow-up for elective hand-related diagnosis and between 3 and 12 months for acute injuries was quantified by effect size calculations.Results The HAKIR Questionnaire (HQ-8) included items concerning pain on load, pain on motion without load, pain at rest, stiffness, weakness, numbness, cold sensitivity and ability to perform daily activities. Correlation coefficients between single-items and total QuickDASH score at pre, 3 and 12 months follow-up ranged from 0.44-0.79. No ceiling effect but a floor effect in the total group was seen in all items at all follow-ups. Percentage of missing item responses was < 2.6% except for the cold sensitivity question. The magnitude of change for individual items varied between small to large effects size in elective hand-related diagnosis. For acute injuries a small effect size was seen between 3 and 12 months follow-up.Conclusions This study provides evidence of content and construct validity of the HQ-8 including lack of ceiling effect, expected floor effect, good data completeness and ability to detect changes in scores over time. Associations between single-items and QuickDASH indicate that HQ-8 measures unique disability aspects important in hand surgery. Further studies are needed to evaluate test-retest reliability, responsiveness including clinically important change of the HQ-8 questions in subgroups of hand-related diagnoses.
Supraspinatus and deltoid muscle fiber diversity in rotator cuff tear conditions
Authors: Ravn Morten Kjaer , Ostergaard Trine Ivarsen , Schroeder Henrik Daa , Nyengaard Jens Randel , Lambertsen Kate Lykke , Frich Lars Henrik 
Published: December 2019

Abstract
Background: Rotator cuff (RC) tears are associated with RC muscle atrophy and changes in composition that are crucial to the prognosis of RC repair. The aim of this study was to characterize muscle fiber composition in the supraspinatus (SS) muscle under tear conditions. Methods: Muscle biopsies were obtained from 21 patients undergoing surgery for RC tendon tear. Biopsies were obtained from the musculotendinous junction of the SS muscle and control biopsies were harvested from the deltoid muscle (DT). Biopsies were immunohistochemically processed for detection of type 1 (slow type) and type 2 (fast type) fibers and analyzed using unbiased, stereological principles. We counted the total numbers of type 1 and 2 muscle fibers/mm 2 and fiber diameter was used to estimate muscle fiber atrophy and hypertrophy. Results: We found significantly more type 2 cells/mm 2 in the SS compared to the DT (p<0.01). In addition, we found a significantly higher fraction of type 1 fibers than type 2 fibers in the DT (p<0.01), whereas both fiber types were equally present in the SS. The diameters of SS cells were generally smaller than those of DT cells. Atrophy of especially SS type 2 fibers was also demonstrated. Fiber atrophy was more pronounced in men than women. Discussion: The changes in the composition of SS muscle cell types suggest a shift from type 1 to type 2 muscle fibers and atrophy of both type 1 and 2 fibers. This composition indicates loss of endurance and rapid fatigue of the SS muscle under RC tear conditions.
WITHDRAWN: Early Patellofemoral Function of Unilateral TKA with Medial Pivot Prostheses is Superior than with Conventional Posterior-Stabilized Prostheses
Authors: Wang Zhen , Zhang Yuqing , Ding Changrong , Cai Xiaoyu , Gao Liang , Wang Yingzhen , Xu Hao 
Published: December 2019

Abstract
PurposeThe purpose of this study was to provide a systematic evaluation of the patellofemoral joint design of Medial Pivot Prosthesis, which incorporates a variety of “Patella-friendly” design features, by comparing clinical and radiographic results with another prosthesis. MethodsEarly clinical and radiographic results of patients who underwent unilateral TKA with Medial Pivot Prosthesis (The study group, including 126 cases) and conventional Posterior-Stabilized Prosthesis (The control group) were retrospectively compared. Postoperative complications, including anterior knee pain, maltracking, patellar clunk or crepitus (PCC), were evaluated.ResultsThe postoperative Kujala score and its improvement from baseline in the study group (Group A) were significantly higher than those in the control group(Group B). The range of motion (ROM) in group A, including the improvement in ROM, was significantly inferior to group B. In the 90-degree Merchant view, the patellar tilt in group A was smaller than that in group B. Two cases of PCC and 3 cases of anterior knee pain were noted in group A, and 9 cases and 6 cases, respectively, were observed in group B. The incidence of PCC was significantly lower in group A. There were no significant between-group differences in the patella tilt angle at 30 or 60° or in the postoperative patellar translation at 30, 60 or 90°. No between-group difference in posterior condyles angle (PCA) was observed. The KSS scores and WOMAC scores between the two groups were similar.ConclusionThe medial pivot prosthesis could achieve satisfactory outcomes with superior patellofemoral performance attributed to its “patella-friendly” design characteristics compared to the conventional posterior-stabilized prosthesis.
Predictors of Duration of Injury-Related Disability Leave
Authors: Curtis William , Marmor Meir 
Published: December 2019

Abstract
Background: Medical leave due to workplace injury is common in the US workforce and creates significant financial drain on the economy. Although there are abundant data relating the duration of medical leave to specific injuries, there is a paucity of research correlating the duration of medical leave with a patient’s attributes or occupation. The primary objective of this study is to examine the influence of specific occupational and patient characteristics on the medical leave taken by employees. Methods: Using records accessed from a major academic institution of 2449 patients reporting medical leave, 547 patients met the inclusion criteria. Worker occupations were divided into three groups based on level of physical activity required for the job. Patient characteristics available for analysis included age, education level, sex, type of injury, and type of medical claim. The association between these factors and duration of disability leave was analyzed using bivariate and multivariable analysis as well Kaplan-Meier survival analysis.Results: Bivariate regression analysis showed that days off work were significantly correlated to physical requirement group (p= 0.0002), age (p=0.00357), injury type (p=0.002), insurance claim type (p=0.0001), injured body part (p=0.001), and level of education (p= 0.0005). On multivariable analysis, physical group, level of education, body part injured, and claim type remained statistically significant. Patient sex did not show significant correlation to days off work.Conclusions: Age, claim type, level of physical requirement, body part injured, and educational requirement are independent predictors of days lost from work following injury. Physicians should be aware of these factors when estimating length of disability leave to patients and their employers.
Sudden death of adults in Togo: Autopsy results of a series of 318 cases
Authors: Darre Tchin , Djiwa Toukilnan , Napo-Koura Gado 
Published: December 2019

Abstract
Objectives: The purpose of the study was to determine the circumstances of occurrence of these sudden deaths, risk factors, to identify the causes of sudden death in adults at autopsy. Results: A total of 318 sudden death cases were recorded. The sex ratio (M/F) was 1.8, and the mean age was 43 ± 0.36 years. Sudden deaths were the second most common reason for autopsies after traffic accidents. The place of death was home in 76.7% of cases and in hospitals in 23.3%. Obesity was noted in 59.4%, with an umbilical adipose panicle varying between 7 and 12 cm thick. Cardiovascular causes excluding cerebral involvement (n=173cases, 54.40%) followed by pulmonary causes (n=100 cases, 31.44%) were the most common cause of sudden death. The predominant cardiac pathology was infarction accounting for 32.07% of all causes of sudden death, and pulmonary embolism with 19.49% was the leading cause at the pulmonary level.
Effectiveness of Tolvaptan in the Treatment for Patients with Autosomal Dominant Polycystic Kidney Disease: A Meta-analysis
Authors: Xie Xuan , Cai Qian , Guo Xiao-Yuan , Bai Dong-Hai , Sheng Hai-Zhong , Wang Bao-Kui , Yan Kai , Lu An-Ming , Wang Xin-Ran 
Published: December 2019

Aim and Objective:
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a
common chronic kidney disease that leads to End-Stage Renal Disease (ESRD). The key target of
this therapy is to prevent the progression of kidney failure. Tolvaptan could slow kidney cyst
growth and are proven highly effective. The aims of this analysis are to perform a systematic
review, estimate and evaluate the efficacy and safety of tolvaptan in ADPKD patients.

Materials and Methods:
Randomized controlled trials of tolvaptan in ADPKD were identified in
PubMed, Ovid, Web of Science and the Cochrane Library electronic database. The changes
observed in kidney function, treatment efficiency and the incidence of adverse events between the
tolvaptan and placebo groups were compared. Data were analyzed by the RevMan software.

Results:
Eight trials, including 7 double-blinded randomised controlled trials and 1 quasi RCT
involving 1,536 patients were extracted. Significant differences in the annual rate of change in the
total kidney volume TKV at any stages of CKD (MD = -3.32, 95%CI =-4.57,-2.07, I2 =70%) and
the glomerular filtration rate (MD = 1.4, 95%CI = 0.83,1.97, I2 =0%) were observed between the
tolvaptan group and the placebo group. Subgroup analysis of patients in different CKD stages also
showed the same conclusion. There was an increase in the urine osmolality, and 24-hour urine
volume in patients receiving tolvaptan. Tolvaptan reduced the rate of serious hypertension and
kidney pain events in ADPKD patients. At higher doses, it increased the rate of adverse events
(liver injuries, thirst, pollakiuria, and nocturia). There was no significant risk of bias in the
included studies.

Conclusions:
Tolvaptan has a beneficial effect on ADPKD, but is associated with an increase in
adverse events at high doses when compared with the placebo. Further RCTs on tolvaptan may be
required to support this conclusion.
Identification of Anti-cancer Peptides Based on Multi-classifier System
Authors: Zhong Wanben , Zhong Bineng , Zhang Hongbo , Chen Ziyi , Chen Yan 
Published: December 2019

Aim and Objective:
Cancer is one of the deadliest diseases, taking the lives of millions
every year. Traditional methods of treating cancer are expensive and toxic to normal cells.
Fortunately, anti-cancer peptides (ACPs) can eliminate this side effect. However, the identification
and development of new anti

Materials and Methods:
In our study, a multi-classifier system was used, combined with multiple
machine learning models, to predict anti-cancer peptides. These individual learners are composed of
different feature information and algorithms, and form a multi-classifier system by voting.

Results and Conclusion:
The experiments show that the overall prediction rate of each individual
learner is above 80% and the overall accuracy of multi-classifier system for anti-cancer peptides
prediction can reach 95.93%, which is better than the existing prediction model.
Preparation and Characterization of β-glucosidase Films for Stabilization and Handling in Dry Configurations
Authors: Zhang Liguang , Shen Yanan , Lu Wenjing , Guo Lengqiu , Xiang Min , Zhang Dayong 
Published: December 2019

Background:
Although the stability of proteins is of significance to maintain protein function
for therapeutical applications, this remains a challenge. Herein, a general method of preserving
protein stability and function was developed using gelatin films.

Method:
Enzymes immobilized onto films composed of gelatin and Ethylene Glycol (EG) were developed
to study their ability to stabilize proteins. As a model functional protein, β-glucosidase was selected.
The tensile properties, microstructure, and crystallization behavior of the gelatin films were assessed.

Result:
Our results indicated that film configurations can preserve the activity of β-glucosidase under
rigorous conditions (75% relative humidity and 37°C for 47 days). In both control films and films containing
1.8 % β-glucosidase, tensile strength increased with increased EG content, whilst the elongation
at break increased initially, then decreased over time. The presence of β-glucosidase had a negligible
influence on tensile strength and elongation at break. Scanning electron-microscopy (SEM) revealed
that with increasing EG content or decreasing enzyme concentrations, a denser microstructure
was observed.

Conclusion:
In conclusion, the dry film is a promising candidate to maintain protein stabilization and
handling. The configuration is convenient and cheap, and thus applicable to protein storage and transportation
processes in the future.
Role of On-Time & Honest Customer Services in the Success of Small Construction Companies in Saudi Arabia
Authors: Bageis Abdulrahman , Alshehri Abdullah 
Published: December 2019

Background:The construction companies need to maintain their success levels to survive in the competitive business environment. The concept of just-in-time plays a significant role to reduce the costs and fulfill the needs of valued customers.Objective:The study aims to evaluate the role of honest customer services that are provided to the construction companies in Saudi Arabia.Methods:The study has used a case study approach to analyze the role of on-time and honest customer services in the success of small construction companies. Interviews were conducted to gather details and characteristics of the associated company. It mainly focused on the interactions and behaviors of participants, rather than calculations.Results:The results have provided a great understanding of the success of construction companies based on success factors. The organizational culture, delayed schedule, required quantity, and just-in-time purchasing are amongst the exceptional and highly effective factors on just-in-time delivery and customer experience. Moreover, organizing and planning were considered to be important factors contributing to company success.Conclusion:There is a strong association between the delivery of honest customer services and the success of construction companies in Saudi Arabia.
Lipid Profile of Pig Tissues Contrasting in Meat Production
Authors: Bekenev Vitaly A. , Arishin Anatoly A. , Mager Sergei N. , Bolshakova Izolda V. , Tretyakova Natalia L. , Kashtanova Elena V. , Polonskaya Yana V. 
Published: December 2019

Background:
Studies were carried out on two breeds of pigs - Pietrain (P), and Kemerovo
(K), contrasting in composition of carcasses, and their hybrids.

Objective:
The purpose of this work was to establish the characteristics of the composition of lipids
of intramuscular fat (IMF), back fat and serum, organoleptic qualities in animals of these breeds.

Methods:
Animals of 10 individuals in each group were fed on a standard feed and slaughtered with
a live weight of 95-100 kg. The quality of carcasses, the biochemical characteristics of blood, the
composition of fatty acids and cholesterol in meat and fat, and blood lipid peroxidation were determined.

Results:
Thickness on the Back Fat (BF) at the level of 6-7 thoracic vertebrae with a live weight of
100 kg was 35.8 ± 1.65 mm in pigs of breed K, in hybrids - 27.6 ± 1.06, and in breed P - 19, 6 ± 1.43
mm. IMF in pigs of breed K was almost 4.5 times greater than that of breed P. IMF K breed contained
2 times less cholesterol than in P (2.34 vs. 4.68%). In the IMF, K was 2 times less polyunsaturated
fatty acids (PUFA), than P, 7.82 and 15.22%, linoleic acid, 6.74% and 12.42%, respectively
(p <0.005). The organoleptic properties of meat and salted back fat were significantly higher in
breed K (P = 0.05).

Conclusion:
The data obtained allow us to establish priorities in the use of products of specific
breeds of pigs, depending on medical requirements.
Analisis level makroskopis, mikroskopis dan simbolik mahasiswa dalam memahami elektrokimia
Authors: Sukmawati Wati 
Published: December 2019

Penelitian ini bertujuan untuk mengetahui tingkat pemahaman mahasiswa dilihat dari aspek makroskopis, mikroskopis dan simbolik dalam memahami konsep. Fenomena pembelajaran kimia yang ditemukan hampir selalu terfokus pada tingkat makroskopik berupa rumus dan angka, sedangkan tingkat yang sering luput dari pengematan adalah tingkat mikroskopik dan simbolik seperti penyajian diagram dan proses reaksi kimia.Salah satu sifat dari ilmu kimia adalah cenderung bersifat abstrak dan kompleks, seperti proses terjadinya reaksi elektrolisis dimana terjadi pergerakan partikel yang tidak dapat diamati oleh mata sehingga sering terjadi miskonsepsi dalam memahami konsep kimia. Penelitian ini dilakukan pada mahasiswa semester satu sebanyak 40 orang di prodi Farmasi Universitas Muhammadiyah Prof. DR. Hamka. Sampel penelitian ini diambil secara purposive random sampling dengan kuisioner. Berdasarkan hasil penelitian diperoleh hasil pemahaman mahasiswa pada konsep elektrokimia dilihat dari level makroskopis sebesar 72,75% kategori baik, level mikroskopis sebesar 66,25% kategori baik dan simbolik adalah 70% kategori baik. Sehingga dapat disimpulkan bahwa pembelajaran dengan aspek makroskopis, mikroskopis, simbolik dapat menanamkan konsep secara utuh. AbstractThis research aims to find out the students’ comprehension from the macroscopic, microscopic, and symbolic aspects of the concept. The phenomenon of chemistry learning that is found almost focused on the macroscopic level in the form of formulas and numbers, while the level that often missed in some observation is microscopic and symbolic levels; such as diagramming and chemical reaction processes. One of the characteristics of chemistry tends to be abstract and complex, as the process of electrolysis reaction in which the particle movement can’t be observed so that misconceptions often occur in understanding chemical concepts. This research was conducted on 40 first-semester students in the Department of Pharmacy, University of Muhammadiyah Prof. DR. Hamka. The research sample was taken by purposive random sampling with a questionnaire. Based on the result, the students’ comprehension of the electrochemistry concept have 72,75% good category in macroscopic level, 66,25% good category in microscopic level, and 70% good category in symbolic. So, it can be concluded that learning with macroscopic, microscopic, and symbolic could fulfill the concept perfectly.
Análise dos indicadores de ciência, tecnologia e inovação no âmbito da Fundação Oswaldo Cruz (Fiocruz)
Authors: Ohayon Pierre , Rosenberg Gerson 
Published: December 2019

Os tomadores de decisão reconhecem que é necessário não só dispor de uma base de dados confiável e efetiva sobre ciência, tecnologia e inovação (CT&I), como também dispor de um modelo de indicadores capaz de dar conta da difícil tarefa de bem avaliar a aplicação dos recursos públicos. O estudo objetivou a formulação de indicadores de CT&I, de forma a contemplar a abordagem holística de uma instituição de pesquisa na área da saúde, a Fundação Oswaldo Cruz (Fiocruz). Levantaram-se os indicadores encontrados principalmente nos relatórios de gestão da Fiocruz, confrontando-os com o modelo conceitual. Como resultado dessa análise comparativa, verificou-se a presença de indicadores com algumas limitações e a falta de indicadores relevantes. Apontaram-se outros indicadores visando a cobrir todas as dimensões e subdimensões do modelo proposto. Sugeriram-se recomendações para que o modelo esteja consistente com as políticas do Ministério da Saúde do Brasil.Palavras-chave: ciência e tecnologia, inovação, indicador, avaliação de programas, administração pública
Comitês de governança de tecnologia da informação na administração pública federal brasileira: fatores críticos de sucesso
Authors: Cunha Marcelo Silva , Neto João Souza 
Published: December 2019

Nos últimos anos, na esfera pública federal brasileira, os órgãos de controle externo e interno vêm enfatizando e estimulando a adoção de estruturas de governança de tecnologia da informação (GTI) junto a toda administração pública federal (APF). O presente trabalho identificou, avaliou (com a participação de especialistas em GTI na APF), e classificou os fatores críticos de sucesso (FCS) para a atuação dos comitês de GTI da APF em dois níveis: estratégico e diretivo. Partiu-se de uma lista universal com quarenta FCS, extraída da literatura especializada, e promoveu-se a avaliação desses por meio do método Delphi. No decorrer das rodadas Delphi, novos FCS foram incluídos pelos especialistas na lista original. Ao final da pesquisa, obteve-se uma lista ordenada por importância relativa de dez FCS para os comitês estratégicos de GTI na APF e doze FCS para os comitês diretivos de GTI na APF.Palavras-chave: administração pública, governança de TI, governança corporativa, tecnologia da informação
Perspektif Riba dan Studi Kontemporer-Nya dengan Pendekatan Tafsir Al Quran dan Hadits
Authors: Parisi Salman Al , Hermawan Iwan , Kurniawan Marta , Habibullah Ibnu Saud 
Published: December 2019

<p><em>Paper ini membahas urgensi dan tahapan pelarangan riba dalam perspektif Islam. Studi ini menggunakan kajian pustaka terkait riba dengan pendekatan tafsir Quran dan Hadits. Secara umum, riba terdiri atas 2 kelompok bagian yaitu riba berdasarkan transaksi hutang piutang (riba qardh dan riba jahiliyyah) serta riba berdasarkan transaksi jual beli barang ribawi (riba fadhl dan riba nasi’ah). Berdasarkan Al- Quran, tahapan larangan riba terdiri atas 4 tahap, yaitu Q.S. Ar-Ruum: 39, Q.S. An-Nisa: 160-161, Q.S. Ali Imran: 130 dan tahap terakhir Q.S. Al-Baqarah: 275-281. Adapun salah satu hadits terkait riba yang diriwayatkan oleh Al-Hakim dari Ibnu Mas’ud bahwa Nabi saw bersabda “Riba itu mempunyai 73 pintu (tingkatan); yang paling rendah (dosanya) sama dengan seseorang yang melakukan zina dengan ibunya”. Maka tidak ada pembenaran dalam mengambil riba, sebagaimana Rasulullah saw menekankan dalam amanat terakhirnya pada tanggal 9 Dzulhijjah tahun 10 Hijriah, “Ingatlah bahwa kamu akan menghadap Tuhanmu dan Dia pasti akan menghitung amalanmu.</em></p><p><em> </em></p><p>Kata Kunci: Riba, Larangan Riba Dalam Al-Quran dan Hadits, Studi Kontemporer</p>