bluuebunny/crossref_metadata_2025_split huggingface dataset:
De Falla's Hungarian Success: A háromszögletű kalap (1928)
Authors: Giménez-Rodríguez Francisco J. 
Published: December 2019

Abstract
In this study, I examine a hitherto completely unknown subject: the Hungarian reception of Manuel de Falla's ballet pantomime, El sombrero de tres picos (The three-cornered hat). As I point out, the story of the piece began well before Falla composed his music: Alarcón's novel was published in a Hungarian translation just two decades after the Spanish original. In the first decades of the twentieth century, the Budapest Opera House (Magyar Állami Operaház) and Municipal Theatre (Városi Színház) developed intensive opera, theatre, and ballet seasons, in association with the main European capitals during the first decades of the twentieth century. De Falla's ballet was premiered in Budapest in 1927 by Diaghilev's Russian Ballet, in the Municipal Theatre under the Hungarian title A háromszögletű kalap. The piece had such success that it had to be repeated three times. What is more, a Hungarian production was premiered in the Budapest Opera House one year later and this production continued until 1963, delivering a total of 75 performances. The sources (among others the handwritten performing scores) of this latter production preserved in the National Széchényi Library and in the Archives of the Hungarian State Opera House reveal an intense work of choreographic adaptation, along with careful design of staging, costumes, lightning, and scenery effects, all accomplished by great international personalities to make this very Spanish ballet understandable to the Magyar audience. Falla's work also found a significant support in the press, highlighting both the plot's universality and the expressiveness of his music, which had made it a Hungarian success.
PERILAKU LESBIAN DALAM NORMATIVITAS HADIS
Authors: Miski Miski 
Published: December 2019

This article aims to explore the ḥadîth thematically on the act of lesbianism in the normative roots. The methods used are operationally by generating ḥadîths that are related to the topic, making typology, defining the primary ḥadîth, takhrîj, and analyzing it in textual and contextual perspective. This article finds that some ḥadîth which are talking straightly on lesbianism are narrated by al-Ṭabrânî. It suggests that the act of lesbianism is a sinful deeds that are similar to the act of sexual intercourse (zinâ). In the wide analysis, it can be noted that Islam does not give space for making it legal for the doers of lesbianism. It is not only because the act of lesbianism has been considered as deviation from the nature of human sexual orientation, but also because it certainly contradicts to the basic legal of human relation. Otherwise, there are ample of ḥ adîth giving instruction to prevent people from such action, that is by not to open and look at other human genitals (‘awrat), not to have body contact that arouse sexual desire, and to emerge awarness of sexual identity and sexs by not to follow the deeds or dressing the opposite gender clothes.
An Open-Label, Single-Arm, Two-Stage, Multicenter, Phase II Study to Evaluate the Efficacy of TLC388 and Genomic Analysis for Poorly Differentiated Neuroendocrine Carcinomas
Authors: Chen Ming-Huang , Chou Wen-Chi , Hsiao Chin-Fu , Jiang Shih Sheng , Tsai Hui-Jen , Liu Yi-Chang , Hsu Chiun , Shan Yan-Shen , Hung Yi-Ping , Hsich Chia-Hsun , Chiu Chao-Hua , Liu Ta-Chih , Cho Shih-Feng , Liu Tsang-Wu , Chao Yee 
Published: December 2019

Abstract

Background
The discovery of effective therapeutic options for treating metastatic poorly differentiated neuroendocrine carcinoma (NEC) after prior platinum-based chemotherapy remains elusive. This study analyzed the efficacy of TLC388 (Lipotecan) Hydrochloride, a novel camptothecin analog, for pretreated patients with metastatic NEC.

Methods
This single-arm, two-stage, phase II clinical trial was conducted at four community and academic centers in Taiwan. Patients aged 20 years or older with confirmed metastatic NEC and who had received prior systemic therapy with etoposide plus cisplatin were enrolled between July 2015 and May 2018. Patients received 40 mg/m2 of TLC388 intravenously on days 1, 8, and 15 of a 28-day cycle until disease progression or unacceptable toxic effects. Gene mutations were analyzed by next-generation sequencing.

Results
Twenty-three patients with a median age of 61 (range, 44–73) years, 18 of whom were men (78%), were enrolled. Patients received a median of 2 (range, 0–6) treatment cycles. Among 20 evaluable patients, 3 patients exhibited stable disease and no patient experienced a complete or partial remission, resulting in a disease control rate of 15%. Median progression-free survival was 1.8 (95% confidence interval [CI], 0.4–15) months, and the median overall survival was 4.3 (95% CI, 1.7–15) months. The most common treatment-related hematologic adverse events at grade 3 or higher were leukopenia (22.7%), anemia (31.8%), and thrombocytopenia (18.2%). The most frequent mutated genes in 35 patients with NEC were ARSA, DPYD, HEXB, BRCA1, HPD, MYBPC3, BBS2, IL7R, HSD17B4, and PRODH.

Conclusion
TLC388 demonstrates limited antitumor activity in metastatic NEC. ClinicalTrials.gov identifier: NCT02457273.

Implications for Practice
Poorly differentiated neuroendocrine carcinomas (NECs) are rare and aggressive. Currently, effective therapeutic options for treating metastatic poorly differentiated NECs beyond platinum-based chemotherapy remain elusive. In this single-arm, multicenter, phase II study, 23 patients with NEC were enrolled and received TLC388 (Lipotecan) Hydrochloride, which is a novel camptothecin analog. The results demonstrated the disease control rate of 15%, the median progression-free survival of 1.8 (95% confidence interval [CI], 0.4–15) months, and the median overall survival of 4.3 (95% CI, 1.7–15) months. Most importantly, several novel genetic mutations and pathways were identified. These results offer the opportunity to develop future treatment strategies in this rare cancer.
Early Steroid Withdrawal in Deceased-Donor Kidney Transplant Recipients with Delayed Graft Function
Authors: Bae Sunjae , Garonzik Wang Jacqueline M. , Massie Allan B. , Jackson Kyle R. , McAdams-DeMarco Mara A. , Brennan Daniel C. , Lentine Krista L. , Coresh Josef , Segev Dorry L. 
Published: December 2019

Significance StatementEarly steroid withdrawal (ESW) is a maintenance immunosuppression strategy to avoid the sequelae of long-term steroid use in kidney transplant (KT) recipients. Recipients with delayed graft function (DGF) may have a suboptimal allograft milieu, which may alter the risk/benefit equation of ESW. In this nationwide study, the authors found use of ESW in recipients with DGF varied at United States transplant centers. The authors also identified differences in outcomes after ESW in patients with and without DGF. Among recipients with immediate graft function, ESW was associated with possible harms such as increased rejection and benefits such as decreased mortality. However, among recipients with DGF, ESW was associated only with possible harms, including increased acute rejection and graft failure. Recipients with DGF also saw no change mortality with ESW. Our findings suggest ESW is harmful in KT recipients with DGF.BackgroundEarly steroid withdrawal (ESW) is associated with acceptable outcomes in kidney transplant (KT) recipients. Recipients with delayed graft function (DGF), however, often have a suboptimal allograft milieu, which may alter the risk/benefit equation for ESW. This may contribute to varying practices across transplant centers.MethodsUsing the Scientific Registry of Transplant Recipients, we studied 110,019 adult deceased-donor KT recipients between 2005 and 2017. We characterized the association of DGF with the use of ESW versus continued steroid maintenance across KT centers, and quantified the association of ESW with acute rejection, graft failure, and mortality using multivariable logistic and Cox regression with DGF-ESW interaction terms.ResultsOverall 29.2% of KT recipients underwent ESW. Recipients with DGF had lower odds of ESW (aOR=0.600.670.75). The strength of this association varied across 261 KT centers, with center-specific aOR of <0.5 at 31 (11.9%) and >1.0 at 22 (8.4%) centers. ESW was associated with benefits and harms among recipients with immediate graft function (IGF), but only with harms among recipients with DGF. ESW was associated with increased acute rejection (aOR=1.091.161.23), slightly increased graft failure (aHR=1.011.061.12), but decreased mortality (aHR=0.860.890.93) among recipients with IGF. Among recipients with DGF, ESW was associated with a similar increase in rejection (aOR=1.12; 95% CI, 1.02 to 1.23), a more pronounced increase in graft failure (aHR=1.16; 95% CI, 1.08 to 1.26), and no improvement in mortality (aHR=1.00; 95% CI, 0.94 to 1.07). DGF-ESW interaction was statistically significant for graft failure (P=0.04) and mortality (P=0.003), but not for rejection (P=0.6).ConclusionsKT centers in the United States use ESW inconsistently in recipients with DGF. Our findings suggest ESW may lead to worse KT outcomes in recipients with DGF.
Territorialización del agronegocio en el Uruguay: una mirada desde la geografía agraria
Authors: Vazquez Sebastián , Ceroni Mauricio Bruno 
Published: December 2019

Nuestro objetivo principal es analizar la configuración de los territorios agrarios del agronegocio en el Uruguay para los sectores de la silvicultura, la agricultura de secano y la ganadería vacuna, desde una perspectiva de la geografía agraria. Para ello realizamos una profunda caracterización de las fases del capital, la producción y la circulación de cada uno de los sectores. Los procedimientos empleados fueron, análisis bibliográfico, recolección y sistematización de los datos agropecuarios, y producción de cartografía temática a escala país. Las fuentes de datos fueron principalmente las diversas dependencias del Ministerio de Ganadería Agricultura y Pesca (MGAP). Ello permitió identificar en el espacio agrario del Uruguay los principales procesos de territorialización del agronegocio, evidenciando, por un lado, que existe una clara concentración espacial de los sectores analizados, y por otro lado, una tendencia en la centralización productiva tanto en la fase productiva como circulatoria del capital, caracterizada por el dominio de capitales transnacionales, reconfigurando los procesos de territorialización históricos del espacio agrario uruguayo.
Kulle (Turnu) ve Niğbolu Kalelerinin Tamirat ve Tahkimi ile Bölgeye Yapılan Avusturya Taarruzları (XVIII. Yüzyılın Son Çeyreğinde)
Authors: FEDAKAR Cengiz 
Published: December 2019

Osmanlı Devleti’nin Avrupa’daki en önemli rakibi XVI. ve XVII. yüzyıllarda Habsburg İmparatorluğu iken XVIII. yüzyılda Rus faktörü kendini göstermiş, yüzyılın son çeyreğinde ise Çarlık Rusyası, Osmanlı’nın mücadele ettiği en büyük düşman hüviyetini almıştı. Osmanlı Devleti, hem Avusturya hem Rusya hudutlarında ve önemli
nehir boylarındaki (Tuna, Turla, Özi gibi) kaleleri, savaş öncesi tahkim ederek hazırlık yapmak durumundaydı. Tuna Nehri’nin iki yakasında yer alan ve nehirde geçiş
denetimini sağlayan Niğbolu ve Kulle kaleleri de XVIII. yüzyılın son çeyreğinde tamir ve tahkimden geçmiştir. Niğbolu Kalesi, Osma Nehri vasıtasıyla Bulgaristan içlerine kadar; Kulle Kalesi ise Alauta Nehri vasıtasıyla Eflak içlerine kadar nüfuz etmekte idiler. Bu yüzden 1774 Küçük Kaynarca Antlaşması sonrasında Niğbolu Kalesi ve özellikle Kulle Kalesi’nde tamirat ve tahkimata büyük önem verilmiştir. Söz konusu kaleler yaklaşık olarak XIX. yüzyılın son çeyreğine kadar fiilen Osmanlı idaresinde
kalmıştır.
Türkçede “Zamanüstülük”
Authors: HİRİK Seçil 
Published: December 2019

Mantık, matematik, felsefe ve dilbilim gibi pek çok disiplin içinde ele alınan ve sınırları sorgulanan zaman kavramı, varlıktan bağımsız akan bir süremdir. Somut
veriler üzerine temellenen dilbilim, zamanı hesaplanabilir olarak ele alma ihtiyacı hissetmektedir. Varlıktan bağımsız olan olgu, gerçek zaman kabul edilirken gerçek
zamanın dilsel formlarla sınırlanmış biçimi eylem zamanı ya da dil bilgisel zaman olarak incelenmiştir. Böylece konuşurun sözceleme anı yani konuşma anı, odak
noktası kabul edilerek eylem zamanı konuşma anına göre oranlanmış ve zamansal bölümlemelere gidilmiştir. Geleneksel dil bilgisinde yapılan geçmiş, şimdiki ve gelecek zaman ayrımının yanı sıra konuşma anına göre konumlandırıldığında eylem zamanı, konuşma anının öncesinde başlamış ve bitmiş, konuşma anının öncesinde başlamış ve konuşma anında devam eden, konuşma anında başlamış ve konuşma anı içinde bitmiş, konuşma anında başlamış ve sonrasında devam eden, konuşma anından sonra başlayacak olma durumuna göre beş dilime ayrılabilir. Bahsi geçen zamansal ulamlar, bir eylemin başlangıç ve bitişini dikkate alarak oluşturulmuştur. Ancak bunlarla beraber zaman çizgisinde gösterilemeyen, süreçle ilgili belirli bir konumu olmayan veya derin yapıda tüm zamanları kapsayan olay ve durumlar da konuşur tarafından dile yansıtılmaktadır. Bu çalışmada literatürde timeless olarak kullanılan ve Türkçede zamanüstü olarak ele alınacak kavram alanı üzerinden kuramsal alt yapı kurulmaya çalışılmıştır. Böylece Türkçede zamanüstülük belirten morfolojik ve leksik yapılar ortaya konulmuştur.
Spolia Use in Murad I Hüdavendigar Mosques in the Çanakkale Region
Authors: AKTUR Hilal 
Published: December 2019

The mosques built in Çanakkale and environs under the commission of Murad I Hüdavendigar or under his name during his reign are referred to as Hüdavendigar mosques. Of these structures, while Behramkale Hüdavendigar and Tuzla Hüdavendigar mosques have survived to the present day, Umurbey Hüdavendigar and Gelibolu Hüdavendigar mosques have undergone restorations, were rebuilt and thus have lost their original properties, with only their names remanining unchanged.
Gelibolu Hüdavendigar Mosque was completely rebuilt in the 19th century and Umurbey Hüdavendigar Mosque was similarly rebuilt in the 20th century. Archival
data and the spolia materials present in their current state were examined in an effort to obtain information regarding the spolia use in their original architecture.
The reused of materials (spolia), which was a common practice in Anatolia since Late Antiquity, came into prominence in Anatolian Seljuk and Beylik Era architecture, at
times functionally and at others as an element of primary decoration1. This article focuses on the explicit use of spolia in the Murad I Hüdavendigar period mosques in the Çanakkale region as an expression of political and religious identity and a sign of power beyond sheer architectural decoration.
O retrato reverso da donna: retrato satírico em metáforas de doce em Fênix Renascida / The Reverse Portrait of the Donna: Satirical Portrait in Candy Metaphors in Fênix Renascida
Authors: Moreira Marcello , Gonçalves José Fernando Sales 
Published: December 2019

Resumo: Este artigo propõe-se analisar um dos gêneros mais produtivos da poesia palaciana portuguesa dos séculos XVI e XVII, o retrato elogioso da donna, de fundo petrarquista, largamente praticado no Quinhentos por poetas como Luís de Camões, Pero de Andrade Caminha e Sá de Miranda, e, no século seguinte, pelos poetas cujas obras foram reunidas nas coletâneas de verso Fênix Renascida e Postilhão de Apolo. Demonstra-se a prática de “notação” do retrato elogioso, discutem-se os preceitos retóricos e poéticos que o regravam, sua utilidade como controle dos afetos cortesãos, e como o seu contrário, o retrato cômico, especificamente aquele construído à base de metáforas de doce, valendo-se dos mesmos lugares comuns de invenção, disposição e elocução do gênero, articula a imagem reversa da donna, transformando a illustratio ou evidentia (de forte apelo visual), própria do retrato de tipo alto, em “apetite”, “gustação”, “gula” e “satisfação sexual”.Palavras-chave: sátira; retrato poético; elogio da donna; ars laudandi; Fênix Renascida.Abstract: This article proposes to analyze one of the most productive poetry genres of Portuguese palace in the 16th and 17th Centuries – praise of a lady, fundamentally Petrarchan, largely practiced in the 1500s by poets such as Luís de Camões, Pero de Andrade Caminha, and Sá de Miranda, and in the following century, by poets whose works were reunited in the collections of verses Phoenix Reborn (Fênix Renascida) and Apollo’s Postilion (Postilhão de Apolo). The practice of “Notation” in the complimentary portrait is demonstrated, the rhetorical and poetic precepts that are rewritten are discussed, its usefulness as a control on courtier affections as well as how its opposite, the comedic portrait, specifically that one built upon sweet metaphors, using the same commonplaces of invention, arrangement and elocution of the genre, articulates the reverse image of a lady, transforming the illustration or evidentia (of strong visual appeal), typical of the higher type portrait, into “appetite”, “gustation”, “gluttony”, and “sexual satisfaction”.Keywords: satire; poetic portrait; praise of a donna; ars laudandi; Phoenix Reborn.
Production of doubled haplois in Brassica purpuraria
Authors: Kozar E. V. , Korottseva K. S. , Romanova O. V. , Chichvarina O. A. , Kan L. Yu. , Ahramenko V. A. , Domblides E. A. 
Published: December 2019

Relevance.In recent years vegetable crop Brassica rapa ssp. chinensis var. purpuraria (synonyms: Brassica campestris L. var.purpurea Bailey; Brassica rapa L. ssp. chinensis var. purpurea) is gaining popularity as an object of genetic and molecular researches, and as an economically valuable vegetable plant due to the high content of biologically active compounds and distinctive economically valuable traits. Effective technology for development DH-plants to accelerate the breeding process for this culture has not been developed yet, so research in this area is relevant.Materials and methods. The study included two varieties from the collection of Vavilov AllRussian Research Institute of Plant Industry (VIR): No. 1301 (China) and No. 1357(Netherlands). Both protocols standard unmodified and with addition of silver nitrate (AgNO3) in the medium for embryogenesis induction were used in experiments for production of DH plants from isolated microspore in vitro. Direct chromosome counting in meristem cells and flow cytometry were used to determine the ploidy of regenerating plants.Results. As a result of the study embryogenesis in B. purpuraria culture can develop with the use of a standard protocol as well as with the addition of silver nitrate that showed a positive effect on the induction of embryogenesis. The yield of embryoids varied depending on the genotype of the individual plant within the variety accession. The highest yield of embryoids was 40 embryoids/petri dish. The main problem at the stage of regeneration is that about half of the regenerating plants occurred to be albinos and were not viable. We show a high degree of spontaneous chromosome doubling in regenerated plants (all analyzed plants were doubled haploids). In total 38 regenerated plants were obtained from accession No. 1301. It was shown that four DH-plants had self-incompatibility after self-pollination, but seed progeny from other plants was obtained. The created material was taken for genetics study and breeding work.
Comparative analysis of nitrate content in fruit and vegetable products by HPLC
Authors: Koptsev S. V. , Glazkov S. V. 
Published: December 2019

Relevance. The quality of food products in Russia and delivered to retail chains for mass consumption is currently one of the most important food safety priorities.Methods. The article contains the results of studies of nitrate content in fruit and vegetable products during 2018-2019 period, obtained from VNIITeK laboratory, comparisons were made with the permissible level of Maximum residue levels (MRL) for nitrate, which are set in Technical regulation TR TS 021/2011. Totally, 252 samples were studied, for the period from January 2018 to April 2018 inclusive 2019.Results. The nitrate content was determined by liquid chromatography. It was shown, that content of nitrate ions in fruit and vegetable products varies in a wide range, depending on the selected group, at the same time, the lowest level of nitrate is established in children 's fruit puree, the highest levels are found in tomato sauce.
Methodological aspects related to biological assessment of insectoacaricides on flower cultures of protected ground
Authors: Dolzhenko T. V. , Makarenko V. I. , Burkova L. A. 
Published: December 2019

Relevance. Analysis of the present range of pesticides that are used in flower orangeries showed critical shortage of allowed pesticides. Now there are no methods for registration testing of insecticides designed to protect flowers in greenhouses. Thus, the purpose of our research is to develop methodological approaches to assessment of abundance of major pests for flower cultures of protected ground and determination of biological effectiveness of new insectoacaricides.Methods. The following phytophages represent flower pests that are predominant in the protected ground: aphids: green peach – Myzus persicae Sulz., melon and cotton – Aphis gossypii Glov., greenhouse-potato – Aulacorthum solani Kalt., potato – Macrosiphum euphorbiae Thom., green rose – Macrosiphum rosae Linn.; whiteflies: greenhouse whitefly – Trialeurodes vaporariorum Wstw., silverleaf whitefly – Bemisia tabaci Genn.; thrips: tobacco – Thrips tabaci Lind., rose – Th. fuscipennis Hal., western flower – Frankliniella occidentalis Perg., heterophagous – F. intonsa Tryb., greenhouse – Heliothrips haemorrhoidalis Bouche; mites: red spider – Tetranychus urticae Koch.; red greenhouse – T. cinnabarinus BoisdResults. Researches related to assessment of abundance of major pests for flower cultures and choosing methods related to determination of biological effectiveness of insectoacaricides were performed in flower orangeries of Leningrad Region on hybrid tea roses Rosa L., chrysnatemums Chrysanthemum L., gerberas Gerbera G. As a result, the algorithm for performing tests related to study of new insectoacaricides on flower cultures in greenhouses is developed. Methodology instructions that we offer for assessment of abundance of major pests for flower cultures of protected ground and determination of biological effectiveness of new insectoacaricides are intended for ensuring the uniform methodological approach to performance of registration tests of modern means to fight against these pests and opportunity for analysis of tests in various agroclimatic areas and obtaining a reasonable general conclusion and findings related to pesticides taking into account international requirements.