bluuebunny/crossref_metadata_2025_split huggingface dataset:
New general relativistic contributions to Mercury’s orbital elements and their measurability
Authors: Iorio Lorenzo 
Published: April 2020

AbstractWe numerically and analytically work out the first-order post-Newtonian (1pN) orbital effects induced on the semimajor axis a, the eccentricity e, the inclination I, the longitude of the ascending node $$\Omega $$Ω, the longitude of perihelion $$\varpi $$ϖ, and the mean longitude at epoch $$\epsilon $$ϵ of a test particle orbiting its primary, assumed static and spherically symmetric, by a distant massive third body X. For Mercury, the rates of change of the linear trends found are $$\dot{I}_\mathrm {1pN}^\mathrm {X} = -4.3\,\mathrm {microarcseconds\,per\,century}\,\left( \upmu \mathrm {as\,cty}^{-1}\right) $$I˙1pNX=-4.3microarcsecondspercenturyμascty-1, $${\dot{\Omega }}_\mathrm {1pN}^\mathrm {X} = 18.2\,\upmu \mathrm {as\,cty}^{-1}$$Ω˙1pNX=18.2μascty-1, $${\dot{\varpi }}_\mathrm {1pN}^\mathrm {X} = 30.4\,\upmu \mathrm {as\,cty}^{-1}$$ϖ˙1pNX=30.4μascty-1, $${\dot{\epsilon }}_\mathrm {1pN}^\mathrm {X} = 271.4\,\upmu \mathrm {as\,cty}^{-1}$$ϵ˙1pNX=271.4μascty-1, respectively. Such values, which are due to the added actions of the other planets from Venus to Saturn, are essentially at the same level of, or larger by one order of magnitude than, the latest formal errors in the Hermean orbital precessions calculated with the EPM2017 ephemerides. The perihelion precession $${\dot{\varpi }}_\mathrm {1pN}^\mathrm {X}$$ϖ˙1pNX turns out to be smaller than some values recently appeared in the literature in view of a possible measurement with the ongoing BepiColombo mission. Linear combinations of the supplementary advances of the Keplerian orbital elements for several planets, if determined experimentally by the astronomers, could be set up in order to disentangle the 1pN N-body effects of interest from the competing larger precessions like those due to the Sun’s quadrupole moment $$J_2$$J2 and angular momentum $$\varvec{S}$$S.
Phase I Study of TAK-659, an Investigational, Dual SYK/FLT3 Inhibitor, in Patients with B-Cell Lymphoma
Authors: Gordon Leo I. , Kaplan Jason B. , Popat Rakesh , Burris Howard A. , Ferrari Silvia , Madan Sumit , Patel Manish R. , Gritti Giuseppe , El-Sharkawi Dima , Chau Ian , Radford John A. , Pérez de Oteyza Jaime , Zinzani Pier Luigi , Iyer Swaminathan , Townsend William , Karmali Reem , Miao Harry , Proscurshim Igor , Wang Shining , Wu Yujun , Stumpo Kate , Shou Yaping , Carpio Cecilia , Bosch Francesc 
Published: April 2020

Abstract

Purpose:
TAK-659 is an investigational, dual SYK/FLT3 inhibitor with preclinical activity in B-cell malignancy models. This first-in-human, dose-escalation/expansion study aimed to determine the safety, tolerability, MTD/recommended phase II dose (RP2D), and preliminary efficacy of TAK-659 in relapsed/refractory solid tumors and B-cell lymphomas.

Patients and Methods:
Patients received continuous, once-daily oral TAK-659, 60–120 mg in 28-day cycles, until disease progression or unacceptable toxicity. The study applied an accelerated dose-escalation design to determine the MTD and RP2D. In the expansion phase, patients with lymphoma were enrolled in five disease cohorts at the MTD.

Results:
Overall, 105 patients were enrolled [dose escalation, n = 36 (solid tumors, n = 19; lymphoma, n = 17); expansion, n = 69]. The MTD was 100 mg once daily. TAK-659 absorption was fast (Tmax ∼2 hours) with a long terminal half-life (∼37 hours). Exposure generally increased with dose (60–120 mg), with moderate variability. The most common treatment-related adverse events were generally asymptomatic and reversible elevations in clinical laboratory values. Among 43 response-evaluable patients with diffuse large B-cell lymphoma, 8 (19%) achieved a complete response (CR) with an overall response rate (ORR) of 28% [23% intent-to-treat (ITT)]. Responses were seen in both de novo and transformed disease and appeared independent of cell-of-origin classification. Among 9 response-evaluable patients with follicular lymphoma, 2 (22%) achieved CR with an ORR of 89% (57% ITT).

Conclusions:
TAK-659 has single-agent activity in patients with B-cell lymphoma. Further studies of the drug in combination, including an evaluation of the biologically optimal and safest long-term dose and schedule, are warranted.
ІДЕНТИФІКАЦІЯ БУДОВИ ПРОДУКТУ ВЗАЄМОДІЇ ВЕРАПАМІЛУ ГІДРОХЛОРИДУ З БРОМКРЕЗОЛОВИМ ЗЕЛЕНИМ
Authors: Sulyma M. I. , Ogurtsov V. V. , Zhuk Y. M. , Vasyuk S. O. , Khomyak S. V. 
Published: April 2020

Мета роботи. Виділення та ідентифікація продукту взаємодії верапамілу гідрохлориду з бромкрезоловим зеленим методами ІЧ-спектрофотометрії та 1H ЯMР спектроскопії.
Матеріали і методи. У дослідженні використано робочий стандартний зразок верапамілу гідрохлориду, бромкрезоловий зелений (БКЗ), взірці готових лікарських форм вітчизняного та зарубіжного виробництва.
Реагенти і розчинники: стандартний зразок верапамілу гідрохлориду, бромкрезоловий зелений, ацетон.
Аналітичне обладнання: Спектрофотометр Bruker Alpha (Bruker Optik GmbH, Ettlingen, Germany) з використанням приставки (повного внутрішнього відбиття) ATR (пряме уведення речовини), спектрофотометр Specord 200 (Німеччина) (190–1100 нм).
Результати й обговорення. Експериментально встановлено, що верапамілу гідрохлорид взаємодіє з бромкрезоловим зеленим у середовищі ацетону з утворенням йонного асоціату. ІЧ-спектр йонного асоціату відповідає сумі поглинань вихідних сполук із деякими відмінностями, що підтверджують його утворення. У йонному асоціаті в області 3600‒3400 см‒1 смуги фенольних –ОН проявляються з меншою інтенсивністю, що можна пояснити перетворенням БКЗ у хінонну структуру. У продукті також відсутні поглинання в області 2370см‒1 (R3N+Cl- у верапамілі гідрохлориді), що пояснюється утворенням йонного асоціату з БКЗ, а саме поглинання проявляється у вигляді уширеного сигналу в області 3200‒2000см‒1.
Висновки. У результаті проведених досліджень встановлено, що верапамілу гідрохлорид взаємодіє з бромкрезоловим зеленим у співвідношенні 1:1, виділено та встановлено будову забарвленого продукту взаємодії верапамілу гідрохлориду з бромкрезоловим зеленим. За допомогою методів ІЧ- спектроскопії та спектрометрії ядерного магнітного резонансу підтверджено, що продуктом взаємодії є йонний асоціат.
АСОРТИМЕНТ ЛІКАРСЬКИХ ПРЕПАРАТІВ ДЛЯ ЛІКУВАННЯ ОБСТРУКТИВНИХ ЗАХВОРЮВАНЬ ДИХАЛЬНИХ ШЛЯХІВ, ПРЕДСТАВЛЕНИЙ НА РИНКУ УКРАЇНИ
Authors: Stadnytska N. Ye. , Мylyanych A. O. , Maltyz I. S. , Fito I. V. , Fedoryshyn O. M. , Komar A. V. , Novikov V. P. 
Published: April 2020

Мета роботи. Провести аналіз асортименту лікарських препаратів для лікування обструктивних захворювань дихальних шляхів (код АТС R03) на сучасному фармацевтичному ринку України та визначити доцільність розробки нових препаратів на підставі маркетингового дослідження.
Матеріали і методи. У роботі використано статистичний і графічний методи.
Результати й обговорення. У результаті проведених маркетингових досліджень та аналізу асортименту лікарських препаратів із кодом АТС R03, зареєстрованих на території України, можна зазначити таке: найбільше лікарських засобів представлено у вигляді порошку для інгаляцій; більшість асортименту (76,1 %) досліджених препаратів складають монопрепарати; частка асортименту препаратів, виготовлених на фармацевтичних підприємствах України складає 21 %; найбільше препаратів виготовляють вітчизняні фірми-виробники ТОВ «Юрія-Фарм» та ТОВ «Мультіспрей».
Висновки. Аналіз ринку фармацевтичних препаратів України показав, що частка вітчизняних засобів є невеликою (21%). Асортимент лікарських форм потребує розширення, зокрема, варто звернути увагу на найменш численні форми: суспензії для розпилення та інгаляцій, розчини для інфузій та гранули.
ДОСЛІДЖЕННЯ ЗІ СТВОРЕННЯ МʼЯКОГО ЛІКАРСЬКОГО ЗАСОБУ З СУХИМ ЕКСТРАКТОМ ШОЛОМНИЦІ БАЙКАЛЬСЬКОЇ
Authors: Slipchenko G. D. , Ruban O. A. 
Published: April 2020

Мета роботи. Провести дослідження з розробки емульгелю з сухим екстрактом шоломниці байкальської, обрати оптимальний гелеутворювач, емульгатор та визначити вміст олійної фази. Вивчити реологічні показники.
Матеріали та методи. Структурно-механічні (реологічні) властивості гелевих основ і зразків вивчали за допомогою ротаційного віскозиметра «Реотест-2» (Німеччина) з коаксіальними циліндрами. Вибір вмісту олійної фази проводили за допомогою методу оптичної мікроскопії. Ступінь дисперсності та визначення лінійних розмірів частинок емульгелю проводили за допомогою електронного мікроскопа «ConusAcademy» із вбудованою фотокамерою. Для вивчення реопараметрів розрахували показники механічної стабільності.
Результати й обговорення. У результаті проведених досліджень до складу емульгелю обрано раціональний гелеутворювач – карбопол Ultrez 10 NF, обрано концентрацію емульгатора Prolipid 141TM та визначено вміст олійної фази. Проведено дослідження реологічних властивостей та механічної стабільності запропонованого складу емульгелю.
Висновки. Як гелеутворювач обрано Ultrez 10 NF (1,5 %), як олійну фазу – олію кукурудзяну (20 %), як емульгатор – Prolipid 141TM (3 %). Доведено, що отриманий емульгель є структурованою системою з пластичним типом течії.
Contribuição dos processos magmáticos e tectono-metamórficos na gênese dos minérios sulfetados de Ni-Cu de Mangabal I e Mangabal II, Goiás, Brasil
Authors: Silva Bruno Venancio da , Lima Filipe Goulart , Assis Rafael Rodrigues , Zanardo Antenor , Godoy Daniel Françoso de 
Published: April 2020

Os complexos estratiformes Mangabal I e Mangabal II fazem parte de um conjunto de intrusões máfico-ultramáficas sinorogênicas, brasilianas, que ocorrem na região central do Brasil. Neste trabalho, são apresentados novos dados petrográficos e de microscopia eletrônica de varredura dos sulfetos de Ni-Cu de ambos os complexos. Em um litotipo com textura cumulática preservada, ocorrem as associações pirrotita-pentlandita e pirrotita-pentlandita-calcopirita na forma de glóbulos de sulfetos intercumulus. A pirrotita apresenta conteúdos de ferro entre 64,9 e 65,5%, a pentlandita apresenta conteúdos de níquel entre 14,6 e 25,3% e a calcopirita apresenta conteúdos de cobre entre 29,1 e 31,5%. Nos litotipos intensamente transformados pelo metamorfismo e que não preservam textura ígnea, ocorrem as associações pirrotita-pentlandita, pirrotita-pentlandita-calcopirita e pirrotita-pentlandita-calcopirita-pirita, todas associadas a concentrações variadas de rutilo. Essas associações apresentam pirrotita com conteúdos de ferro entre 59,1 e 62,1%, pentlandita com conteúdos de níquel entre 15 e 40% e calcopirita com conteúdos de cobre entre 32,9 e 36,6%. A associação pentlandita-pirita, bem como vênulas compostas de pirita ou calcopirita, constituem fases de substituição e remobilização dos sulfetos preexistentes. Baseando-se na mineralogia, na textura e nos conteúdos de metais base, observa-se que as associações de sulfetos encontradas nos litotipos intensamente transformados pelo metamorfismo são semelhantes em ambos os complexos e diferem das associações encontradas no litotipo que preserva textura ígnea. Dessa forma, sugere-se que os processos tectono-metamórficos atribuídos ao Ciclo Brasiliano ocasionaram remobilizações e mudanças químicas nos sulfetos de Ni-Cu dos complexos Mangabal I e Mangabal II.
Oxygen Exposure During Cardiopulmonary Resuscitation Is Associated With Cerebral Oxidative Injury in a Randomized, Blinded, Controlled, Preclinical Trial
Authors: Marquez Alexandra M. , Morgan Ryan W. , Ko Tiffany , Landis William P. , Hefti Marco M. , Mavroudis Constantine D. , McManus Meagan J. , Karlsson Michael , Starr Jonathan , Roberts Anna L. , Lin Yuxi , Nadkarni Vinay , Licht Daniel J. , Berg Robert A. , Sutton Robert M. , Kilbaugh Todd J. 
Published: April 2020

Background

Hyperoxia during cardiopulmonary resuscitation (CPR) may lead to oxidative injury from mitochondrial‐derived reactive oxygen species, despite guidelines recommending 1.0 inspired oxygen during
CPR
. We hypothesized exposure to 1.0 inspired oxygen during
CPR
would result in cerebral hyperoxia, higher mitochondrial‐derived reactive oxygen species, increased oxidative injury, and similar survival compared with those exposed to 21% oxygen.

Methods and Results

Four‐week‐old piglets (n=25) underwent asphyxial cardiac arrest followed by randomization and blinding to
CPR
with 0.21 (n=10) or 1.0 inspired oxygen (n=10) through 10 minutes post return of spontaneous circulation. Sham was n=5. Survivors received 4 hours of protocolized postarrest care, whereupon brain was obtained for mitochondrial analysis and neuropathology. Groups were compared using Kruskal‐Wallis test, Wilcoxon rank‐sum test, and generalized estimating equations regression models. Both 1.0 and 0.21 groups were similar in systemic hemodynamics and cerebral blood flow, as well as survival (8/10). The 1.0 animals had relative cerebral hyperoxia during
CPR
and immediately following return of spontaneous circulation (brain tissue oxygen tension, 85% [interquartile range, 72%–120%] baseline in 0.21 animals versus 697% [interquartile range, 515%–721%] baseline in 1.0 animals;
P
=0.001 at 10 minutes postarrest). Cerebral mitochondrial reactive oxygen species production was higher in animals treated with 1.0 compared with 0.21 (
P
<0.03). Exposure to 1.0 oxygen led to increased cerebral oxidative injury to proteins and lipids, as evidenced by significantly higher protein carbonyls and 4‐hydroxynoneals compared with 0.21 (
P
<0.05) and sham (
P
<0.001).

Conclusions

Exposure to 1.0 inspired oxygen during
CPR
caused cerebral hyperoxia during resuscitation, and resultant increased mitochondrial‐derived reactive oxygen species and oxidative injury following cardiac arrest.
The Iconostasis and Darśan in Orthodox Christianity and Mahāyāna Buddhism
Authors: Shin Junhyoung Michael 
Published: April 2020

Abstract
This essay discusses how Orthodox Christianity and Mahāyāna Buddhism understood the acts of both seeing and being seen by the divine, and how such ideas affected the making and use of icons in these two religious traditions. I focus on the visual culture of the Byzantine and Russian Orthodox churches between the eleventh and fifteenth centuries, and that of the East Asian Pure Land and Esoteric schools between the ninth and fourteenth centuries, respectively. I interpret the function of the iconostasis as an enduring remnant of the Jewish veil used to obstruct God’s vision. Here, Jacques Lacan’s concepts of the gaze and the screen provide a thought-provoking rationale. In turn, I investigate the mandala and icon in Japanese Esoteric Buddhism, in which both seeing and being seen by the divine were deemed spiritual blessings granted by the divine being. This thematic comparison brings to light the less discussed aspects of Christian and Buddhist visual experiences.
The Question of Justice in the Novel of Consciousness
Authors: Vander Weele Michael 
Published: April 2020

Abstract
Marilynne Robinson’s achievement in the third novel of the Iowa trilogy can be seen more clearly if measured against Erich Auerbach’s ambivalence about the novel of consciousness. Using Auerbach’s final chapter of Mimesis, on Virginia Woolf, as the horizon for Robinson’s work clarifies two points: Robinson’s work should be viewed within a novel-of-consciousness tradition that is as much European as American; and Robinson’s religious interests turn that tradition toward a more anthropological concern with the complexity of consciousness framed by the concern for justice. While Nicholas Damas’s recent essay in The Atlantic, “The New Fiction of Solitude” (April 2016), claimed that much new fiction “imagines teaching us how to be separate” and Walter Benjamin already wrote at mid-century that “the ability to exchange experiences” disappeared sometime after World War I, in Lila it is as if Marilynne Robinson set out to show both the difficulty and the possibilities of such exchange.
Strongly Coupled Data Assimilation Using Leading Averaged Coupled Covariance (LACC). Part III: Assimilation of Real World Reanalysis
Authors: Sun Jingzhe , Liu Zhengyu , Lu Feiyu , Zhang Weimin , Zhang Shaoqing 
Published: April 2020

Abstract
Recent studies proposed leading averaged coupled covariance (LACC) as an effective strongly coupled data assimilation (SCDA) method to improve the coupled state estimation over weakly coupled data assimilation (WCDA) in a coupled general circulation model (CGCM). This SCDA method, however, has been previously evaluated only in the perfect model scenario. Here, as a further step toward evaluating LACC for real world data assimilation, LACC is evaluated for the assimilation of reanalysis data in a CGCM. Several criteria are used to evaluate LACC against the benchmark WCDA. It is shown that despite significant model bias, LACC can improve the coupled state estimation over WCDA. Compared to WCDA, LACC increases the globally averaged anomaly correlation coefficients (ACCs) of sea surface temperature (SST) by 0.036 and atmosphere temperature at the bottom level (Ts) by 0.058. However, there also exist regions where WCDA outperforms LACC. Although the reduction in the anomaly root-mean-square error (RMSE) is not as consistently clear as the increase in ACC, LACC can largely correct the biased model climatology.
Systemic lupus erythematosus–associated diffuse alveolar hemorrhage: a single-center, matched case–control study in China
Authors: Sun Yiduo , Zhou Cong , Zhao Jiuliang , Wang Qian , Xu Dong , Zhang Shangzhu , Shen Min , Hou Yong , Tian Xinping , Li Mengtao , Zeng Xiaofeng 
Published: April 2020

Background This study described clinical characteristics and outcome in systemic lupus erythematosus (SLE) patients with diffuse alveolar hemorrhage (DAH), and investigated risk factors and prognostic factors for DAH. Methods We conducted a retrospective nested case–control analysis in a single-center cohort. We enrolled 94 SLE patients with DAH. For each case of DAH, two age-, sex-, and SLE courses–matched controls were randomly selected from our cohort. All patients were enrolled between 2004 and 2019 and were followed until death, end of registration with the physician’s practice, or end of January 2019. We estimated the risk factors for DAH and prognostic factors for mortality using multivariate analysis. Results We included 4744 patients diagnosed with SLE, with 94 cases of DAH, for an incidence rate of 2.0%. DAH may occur in any stage of SLE but mostly in the early phase of disease course. Lupus nephritis (LN) was the most common concomitant involvement at DAH diagnosis. By multivariate analysis, LN, anti-SSA positivity, thrombocytopenia and elevated C-reactive protein (CRP) were significantly associated with DAH in SLE patients. All-cause mortality was increased in SLE with DAH compared with SLE without DAH (adjusted hazard ratio 6.0, 95% confidence interval 2.8–13.0, p < 0.0001). Intravenous cyclophosphamide (CTX) showed an increased tendency for better survival in DAH after adjusting for Systemic Lupus Erythematosus Disease Activity Index 2000, acute kidney injury and mechanical ventilation. Conclusions LN, anti-SSA positivity, thrombocytopenia and elevated CRP were independent risk factors of DAH in lupus patients. Due to a high early death rate of DAH and little long-term damage, DAH patients may benefit from early diagnosis and intensive treatment, and CTX-based therapy can be a preferential choice.
Vitamin D Treatment Attenuates Heart Apoptosis After Coronary Artery Bypass Surgery: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Authors: Tasdighi Erfan , Hekmat Manouchehr , Beheshti Mahmoud , Baghaei Ramin , Mirhosseini Seyed Mohsen , Torbati Peyman , Pourmotahari Fatemeh , Foroughi Mahnoosh 
Published: April 2020

Background: Vitamin D plays an important role in immune system and in the regulation of inflammatory cytokines. Coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB) is associated with an extensive inflammatory response. The aim of this study is to examine the effect of vitamin D treatment on the apoptosis and inflammatory changes developed after CABG. Methods: This trial was conducted on 70 patients undergoing CABG with CPB. Patients were randomly administered either in placebo or in the group of orally consuming 150 000 IU vitamin D daily for 3 consecutive days before surgery. The right atrium sample was taken to assess caspases 2, 3, and 7 activity using immunohistochemistry method. The serum level of interleukin-10 (IL-10) and insulin-like growth factor 1 (IGF-1) were compared at intervals. Results: The average number of positive cells for caspases 2 and 3 were less in vitamin D group ( P = .006 and P < .001, respectively). There was an increase in serum levels of IL-10 after 3 days from vitamin D treatment before surgery (vitamin D group = 4.4 ± 4.9 ng/mL and control group = 1 ± 0.5 ng/mL, P = .001). After operation, IL-10 increased in both groups, higher level in vitamin D group ( P < .001). The comparison of serum IGF-1 showed significant difference after 3 days ( P = .006) and remained higher in vitamin D group after CPB ( P < .001). Conclusions: These findings suggest the apoptosis rate after CPB can be reduced by vitamin D. Vitamin D treatment may improve the inflammatory status before and after surgery. Further studies are needed to confirm the antiapoptotic property of vitamin D and clinical implication.
Effects of diabetes duration and HgA1C level on corneal endothelial morphology
Authors: Çolak Salih , Kazanci Burcu , Ozçelik Soba Dilek , Ozdamar Erol Yasemin , Yilmazbas Pelin 
Published: April 2020

Objective: The aim of this study is to investigate the effects of the HbA1c level and the duration of diabetes mellitus on the corneal endothelium morphology and to compare between healthy individuals and diabetes mellitus patients with non-proliferative diabetic retinopathy and proliferative diabetic retinopathy. Material and methods: Ninety patients who applied to the Health Sciences University Ulucanlar Eye Training and Research Hospital between January 2016 and January 2017 were included in this prospective randomized study. In the study, 45 diabetes mellitus patients and 45 healthy individuals were evaluated. The diabetes patients were compared in terms of HbA1c level, diabetes mellitus duration, corneal endothelial cell density, coefficient of variation, standard deviation, and hexagonality with healthy control group. Results: A statistically significant difference was found in the endothelial cell densitometer, coefficient of variation, and standard deviation measurements between the diabetes mellitus patients and the control (healthy) group. But, there was no statistically significant difference between 6A (hexagonality) and central corneal thickness measurements. There was a negative correlation between HbA1c levels and diabetes mellitus times and endothelial cell densitometer values in the patients with diabetes mellitus diagnosis and standard deviation values in the positive direction. There was a statistically significant difference between diabetes mellitus patients with the diagnosis of non-proliferative diabetic retinopathy and proliferative diabetic retinopathy in the endothelial cell densitometer and standard deviation values. But there was not any statistically significant difference between coefficient of variation, 6A, and central corneal thickness values. Conclusion: The endothelial cell densitometer in diabetes mellitus patients with retinopathy is lower than that in healthy individuals. There is a negative correlation between retinopathy severity and corneal endothelial cell density. Diabetes affects negatively not only vascular tissues but also avascular cornea.