bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Therapist Feedback on the Therapeutic Alliance and Alcohol Use Outcomes in the Outpatient Treatment of Alcohol Use Disorder
Authors: Maisto Stephen A. , Schlauch Robert C. , Connors Gerard J. , Dearing Ronda L. , O'Hern Kelly A. 
Published: February 2020

BackgroundIt is widely accepted that the therapeutic alliance (TA) is a mediator of psychotherapy effects, but evidence is sparse that the TA is an actual mechanism of behavior change. The purpose of this study was to provide the first systematic evidence regarding the TA as a mechanism of change in the treatment of alcohol use disorder (AUD).MethodsParticipants were 155 adult men and women presenting for individual outpatient treatment of AUD. Each was randomly assigned to 1 of 6 experienced therapists, who did or did not receive over 3 study phases postsession participant feedback on his/her ratings of the TA. All participants received a 12‐session version of cognitive behavioral therapy for AUD. Participants rated the TA by use of the California Psychotherapy Alliance Scale (CALPAS) and reported their daily alcohol consumption between sessions and for 1 year posttreatment by use of the timeline followback interview. Multilevel statistical models that partitioned within‐ and between‐participant effects and between‐therapist effects were run to test the effects of feedback condition on the alliance and alcohol use, and the effects of the alliance on alcohol use.ResultsThe study's main hypotheses that feedback causes an enhanced therapeutic alliance and that the alliance is associated with better alcohol use outcomes were not supported.ConclusionsSeveral methodological and substantive reasons for the pattern of findings are suggested, as well as directions for future research that would advance study of the TA as a mechanism of change in psychotherapy and in studying therapist effects on outcomes in general.
Perturbations in Mitochondrial Dynamics Are Closely Involved in the Progression of Alcoholic Liver Disease
Authors: Palma Elena , Riva Antonio , Moreno Christophe , Odena Gemma , Mudan Satvinder , Manyakin Nikolai , Miquel Rosa , Degré Delphine , Trepo Eric , Sancho‐Bru Pau , Altamirano Jose , Caballeria Juan , Zamalloa Ane , Menon Krishna , Heaton Nigel , Williams Roger , Bataller Ramon , Chokshi Shilpa 
Published: February 2020

BackgroundMitochondria play a fundamental role in the pathogenesis of alcoholic liver disease (ALD). The preservation of functional mitochondria during toxic alcohol insults is essential for cell survival and is maintained by key processes known as mitochondrial dynamics, including fragmentation and fusion, which are regulated by mitochondria‐shaping proteins (MSP). We have shown mitochondrial dynamics to be distorted by alcohol in cellular and animal models, but the effect in humans remains unknown.MethodsHepatic gene expression of the main MSP involved in the mitochondrial fusion and fragmentation pathways was evaluated in patients with alcoholic hepatitis (AH) by DNA microarray (n = 15) and Reverse Transcription Polymerase Chain Reaction (n = 32). The activation of dynamin‐1‐like protein (Drp1) was also investigated in mitochondria isolated from liver biopsies of ALD patients (n = 8). The effects of alcohol on mitochondrial dynamics and on MSP protein expression were studied in human precision‐cut liver slices (PCLS) exposed for 24 hours to increasing doses of ethanol (EtOH; 50 to 250 mM).ResultsA profound hyperactivation of the fragmentation pathway was observed in AH patients, with a significant increase in the expression of Drp1 and its adapters/receptors. The translocation of Drp1 to the mitochondria was also induced in patients with severe ALD and was affected in the PCLS with short‐term exposure to EtOH but only mildly. The fusion pathway was not altered in ALD, and this was confirmed in the PCLS model.ConclusionsThe present study reveals the role of mitochondrial dynamics in human ALD, confirming our previous observations in animal and cell culture models of ALD. Taken together, we show that alcohol has a significant impact on the fragmentation pathway, and we confirm Drp1 as a potential therapeutic target in severe ALD.
Dynamic cyclic and torsional fatigue resistance of TruNatomy compared with different nickel–titanium rotary instruments
Authors: Elnaghy Amr M. , Elsaka Shaymaa E. , Elshazli Alaa H. 
Published: February 2020

AbstractThis study evaluated the dynamic cyclic and torsional fatigue resistance of recently introduced TruNatomy instruments (TRN) and compare with HyFlex CM (HFC), Vortex Blue (VB) and FlexMaster (FM) instruments. Size 20, 0.04 taper of TRN, HFC, VB and FM instruments was tested for dynamic cyclic and torsional fatigue resistance. Dynamic cyclic fatigue resistance was evaluated using an artificial canal with a radius of 5 mm and a 90° angle of curvature. The number of cycles to failure (NCF) was calculated. The dynamic torsional fatigue resistance was evaluated by holding a 5 mm of the tip of each instrument in a metal block with composite resin. Torsional fatigue resistance was recorded by counting the number of load applications before fracture for each instrument. The HFC instruments had greater fatigue resistance than VB, TRN and FM. FM had a higher resistance to torsional stress than TRN, HFC and VB instruments.
Evaluation of the attraction, lethal and sublethal effects of the faeces of ivermectin‐treated cattle on the dung beetle Digitonthophagus gazella (Coleoptera: Scarabaeidae)
Authors: Rodríguez‐Vivas Roger I , Basto‐Estrella Gertrudis S , Reyes‐Novelo Enrique , Arceo‐Moran Andreyna Arisbe , Arcila‐Fuentes William R , Ojeda‐Chi Melina M , Martínez‐M Imelda 
Published: February 2020

AbstractThe attraction of the Digitonthophagus gazella dung beetle to the excreta of cattle treated with ivermectin (IVM) at 1% under controlled and field conditions (Phase 1) as well as the lethal (mortality) and sublethal effects (fecundity, emergence, and dung removal) of the excreta of bovines treated with IVM‐1% and IVM‐3.15% were evaluated (Phase 2). In Phase 1, an olfactometer was used to evaluate the attraction/repellency in the laboratory and field‐controlled conditions using faeces of cattle recovered on 5, 14, 21 and 28 days posttreatment (DPT) from animals treated with IVM‐1% (0.2 mg/kg) and untreated animals. Under field conditions, pitfall traps baited with faeces from animals treated with IVM‐1% (5 DPT), and untreated animals were used to evaluate the attraction/repellency for D. gazella. In all three experiments, the faeces of treated cattle did not affect (P > 0.05) the attraction/repellency of D. gazella towards IVM‐1% (P > 0.05). In Phase 2, six cattle were used: (1) three treated with subcutaneous IVM‐1% 0.2 mg/kg and (2) three treated with subcutaneous IVM‐3.15% (0.63 mg/kg). The collection of faeces was at −1 (control), 5, 14, 21 and 28 DPT. Each bioassay consisted of a terrarium with a pair of sexually mature beetles, where they received 50 g of faeces for 10 days with 15 replicates per group. The bioassays consisted of nine groups: control, IVM‐1% at 5, 14, 21 and 28 DPT and IVM‐3.15% at 5, 14, 21 and 28 DPT. There were no lethal effects on adults of D. gazella when exposed to faeces treated with IVM‐1% and IVM‐3.15%; however, faeces collected at 5 DPT from cattle treated with IVM‐1% and IVM‐3.15% showed a significant reduction in the average number of brood masses produced and in the average number of imagoes emerged (P < 0.05). There were no differences in faeces removal between treatments. In conclusion, D. gazella does not discriminate between faeces of cattle treated with IVM and untreated, and there were no lethal effects seen; however, fertility was significantly reduced at 5 DPT.
A study on morphology and morphometric parameters on skull of the Bardhoka autochthonous sheep breed in Kosovo
Authors: Gündemir Ozan , Duro Sokol , Jashari Tefik , Kahvecioğlu Oya , Demircioğlu İsmail , Mehmeti Hajrip 
Published: February 2020

AbstractIn this study, we aim to investigate the skull of Bardhoka sheep, which is the native breed of Kosovo by utilising normal morphometric methods. Differences between male and female were also statistically analysed. Further, the parameters that can be used in gender discrimination were also analysed. The statistical analysis was based on a sample of 24 adult skulls of Bardhoka breed with 12 female and 12 male skulls. Altogether, 31 different measurements were taken morphologically and 7 different indices were applied. Except for the measurement's values of the orbit, measurement's values of length of the cheek tooth row and the measurement's values of height of the foramen magnum, all the measured values of males were higher than females. Nasal index, cranium index and skull index values were statistically significant between both genders. It is envisaged that the findings of this study will motivate and assist other comparative studies with other autochthonous sheep and goat breeds found in the Dukagjini region or in clinical veterinary practice and even in zooarchaeology.
Predictive value of P wave terminal force in lead V1 for atrial fibrillation: A meta‐analysis
Authors: Huang Zhuoshan , Zheng Zhenda , Wu Bingyuan , Tang Leile , Xie Xujing , Dong Ruimin , Luo Yanting , Li Suhua , Zhu Jieming , Liu Jinlai 
Published: February 2020

AbstractBackgroundSeveral studies have explored the association between P wave terminal force in lead V1 (PTFV1) and risk of atrial fibrillation (AF) occurrence, but the results were controversial. This meta‐analysis aimed to examine whether abnormal PTFV1 could predict AF occurrence.MethodsWe searched PubMed, Embase, and Cochrane Library databases for articles published before August 25, 2018. Pooled odds ratios (ORs) of AF occurrence were calculated using random‐effects models to explore the significance of PTFV1.ResultsA total of 12 studies examining 51,372 participants were included, with 9 studies analyzing PTFV1 as a categorical variable and 4 studies analyzing PTFV1 as a continuous variable. As a categorical variable, abnormal PTFV1 (>0.04 mm s) was significantly associated with AF occurrence with a pooled OR of 1.39 (95% confidence interval [CI] 1.08–1.79, p = .01). Subgroup analysis found that ORs of studies in hemodialysis patients (OR = 4.89, 95% CI 2.54–9.90, p < .001) and acute ischemic stroke patients (OR = 1.60, 95% CI 1.14–2.25, p = .007) were higher than general population (OR = 1.15, 95% CI 1.03–1.29, p = .01). Studies from Europe (OR = 1.05, 95% CI 0.91–1.20, p = .51) yielded lower OR of endpoints compared with Asia (OR = 1.89, 95% CI 1.38–2.60, p < .001) and United States (OR = 1.43, 95% CI 1.19–1.72, p < .001). As a continuous variable, PTFV1 was also significantly associated with AF occurrence with a polled OR per 1 standard deviation (SD) change of 1.27 (95% CI 1.02–1.59, p = .03).ConclusionsPTFV1 was significantly associated with the risk of AF and was considered to be a good predictor of AF occurrence in population with or without cardiovascular diseases.
Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs: A population‐based nested case–control study
Authors: Zhang Yumao , Souverein Patrick C. , Gardarsdottir Helga , van den Ham Hendrika A. , Maitland‐van der Zee Anke‐Hilse , de Boer Anthonius 
Published: February 2020

AimsTo assess the association between concurrent use of potential pharmacokinetic or pharmacodynamic interacting drugs and major bleeding among direct oral anticoagulant (DOAC) users.MethodsWe performed a case–control study nested in a cohort of new users of DOACs (dabigatran etexilate, apixaban or rivaroxaban). Data were obtained from the UK Clinical Practice Research Datalink linked to Hospital Episode Statistics (2008–2015). Cases were patients hospitalized having a primary diagnosis of major bleeding. Up to 4 controls were matched on age, sex, index date and region. Odds ratios (ORs) for the risk of major bleeding were assessed by conditional logistic regression analysis and adjusted for well‐known covariates for the risk of bleeding.ResultsWe identified 393 patients with a major bleeding from a total of 23 492 new users of DOACs and 1494 matched controls. Most subjects were users of rivaroxaban (58.8%) on the index date. The concurrent use of pharmacodynamic interacting drugs was associated with an increased risk of major bleeding (21.6% of cases vs 13.5% of controls, adjusted odds ratio [aOR] 1.92; 95% confidence interval [CI], 1.40–2.66). For the antiplatelet drugs the aOR was 2.01 (95% CI, 1.29–3.11) and for the selective serotonin reuptake inhibitors the aOR was 1.68 (95% CI, 1.10–2.59). We found no increased risk of major bleeding for concurrent use of pharmacokinetic interacting drugs vs DOACs alone (45.0 vs 51.2%; aOR: 0.77; 95% CI: 0.53–1.10).ConclusionAmong patients taking DOACs the concurrent use of antiplatelet drugs or selective serotonin reuptake inhibitors was associated with increased risk of major bleeding, while pharmacokinetic interacting drugs do not increase this risk.
Allogeneic stem cell transplantation in AML with t(6;9)(p23;q34);DEK‐NUP214 shows a favourable outcome when performed in first complete remission
Authors: Díaz‐Beyá Marina , Labopin Myriam , Maertens Johan , Alijurf Mahmoud , Passweg Jakob , Dietrich Beelen , Schouten Harry , Socié Gerard , Schaap Nicolaas , Schwerdtfeger Rainer , Volin Liisa , Michallet Mauricette , Polge Emmanuelle , Sierra Jorge , Mohty Mohamad , Esteve Jordi , Nagler Arnon ,   the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)
Published: February 2020

SummaryAcute myeloid leukaemia (AML) with t(6;9)(p23;q34) is a poor‐risk entity, commonly associated with FLT3‐ITD (internal tandem duplication). Allogeneic stem‐cell tranplantation (allo‐SCT) is recommended, although studies analysing the outcome of allo‐SCT in this setting are lacking. We selected 195 patients with t(6;9) AML, who received a first allo‐SCT between 2000 and 2016 from the EBMT (European Society for Blood and Marrow Transplantation) registry. Disease status at time of allo‐SCT was the strongest independent prognostic factor, with a two‐year leukaemia‐free survival and relapse incidence of 57% and 19% in patients in CR1 (first complete remission), 34% and 33% in CR2 (second complete remission), and 24% and 49% in patients not in remission, respectively (P < 0·001). This study, which represents the largest one available in t(6;9) AML, supports the recommendation to submit these patients to allo‐SCT in CR1.
Critical analysis of a multicentric experience with holmium laser enucleation of the prostate for benign prostatic hyperplasia: outcomes and complications of 10 years of routine clinical practice
Authors: Romero‐Otero Javier , García‐Gómez Borja , García‐González Lucía , García‐Rojo Esther , Abad‐López Pablo , Justo‐Quintas Juan , Duarte‐Ojeda José , Rodríguez‐Antolín Alfredo 
Published: February 2020

ObjectiveTo assess the perioperative outcomes of holmium laser enucleation of the prostate (HoLEP) in real‐life practice and investigate the factors influencing the safety and effectiveness of the technique.Patients and MethodsCritical analysis of patients with benign prostate hyperplasia (BPH) treated with HoLEP over 10 years of routine practice in three hospitals. Analysed variables included: preoperative characteristics (prostate size, active antiplatelet/anticoagulant therapy, blood parameters. prostate‐specific antigen (PSA) level, maximum urinary flow rate [Qmax], and International Prostate Symptom Score [IPSS]), intraoperative variables (operation time, concomitant removal of bladder calculi, and complications), early postoperative outcomes (change in blood parameters, catheterisation time, and hospital stay), and 12‐month follow‐up outcomes (change in IPSS, PSA level, and Qmax).ResultsThe analysis included 963 patients, aged 48–91 years, with a mean (range) prostate size of 91 (35–247) mL. The mean (sd) operation time was 77 (29) min, and the hospital stay and catheterisation time were 4 (2) and 1.3 (2) days, respectively. In all, 56 patients (5.6%) required concomitant removal of bladder calculi and 36 (3.7%) were converted to open prostatectomy or transurethral resection of the prostate due to intraoperative complications. Patients had a significant decrease in haemoglobin and haematocrit, but no differences were seen between patients with and without anticoagulant/antiplatelet therapy and those with prostates ≥ and <100 mL. The concomitant removal of bladder calculi and having a prostate ≥100 mL resulted in a longer operation time, but did not influence the safety and effectiveness outcomes.ConclusionsHoLEP is suitable for real‐life patients with BPH, irrespective of the presence of active treatment with anticoagulant/antiplatelet, bladder lithiasis or a prostate ≥100 mL.
Comparing the Social Attitudes of Young Adult Evangelicals in Canada and the United States: Differences in Subcultural Boundaries among Evangelical School Graduates
Authors: Reimer Sam , Sikkink David 
Published: February 2020

AbstractIn this study, we examine social trust and the social attitudes of young adult evangelicals in the United States and Canada to better understand how national context shapes these attitudes. While some differences are predictable in light of national cultural differences, other differences between Canadian evangelical school graduates and American evangelical school graduates do not mirror national differences in the larger population of public school graduates. Here we suggest that differences are better understood by the ways evangelicals draw selectively from their cultural (and religious subcultural) repertoires to create unique boundaries. In general, we find lower levels of social trust and more restrictive subcultural boundaries in the United States.
SANTAMARINE: Mechanistic studies on multiple diseases
Authors: Jalal Sajid , Ahmad Bashir , Zhang Ting , Guo Lianying , Huang Lin 
Published: February 2020

AbstractMedicinal plants are vital sources of modern and traditional Chinese medicines. Sesquiterpene lactones (SLs) consist of a large group of plant secondary metabolites and belong to C15 terpenoid group. SLs have shown various biological activities including antitumor and anti‐inflammatory activities. Santamarine (STM), C15H20O3, is a kind of sesquiterpene lactone, whose molecular weight is 248.322 g/mol. Santamarine has been isolated from several plants species and has shown eminent biological activities, such as anticancer activity and anti‐inflammatory activity. In this mini‐review, we summarize the studies on the effects and the mechanisms of STM, and explore the avenues of application.
Comparative QSAR model generation using pyrazole derivatives for screening Janus kinase‐1 inhibitors
Authors: Sarithamol Suvarna , Pushpa Vadakkethil Lalithabhai , Divya Vasanthakumari , Manoj Kanthimathi Bahuleyan 
Published: February 2020

AbstractAsthma is a multitargeted disease. IL‐4‐JAK‐STAT signaling pathway is a promising route for the effective control of the disease. JAK inhibition by small molecules could effectively block the IL‐4 signaling pathway. It was established that JAK1 is responsive toward IL‐4‐mediated signaling process. In the present study, three‐dimensional QSAR analyses on a set of pyrazole derivatives against JAK1 and JAK2 enzyme inhibition had been executed. Molecular docking studies were conducted with the target JAK1 using the pyrazole derivative compounds and found out potential intermolecular interactions operating among them. The binding energy of all the derivative compounds with the target JAK1 has calculated and found out their affinity toward the target system. These models have predicted the JAK1 inhibitory activity of some five JAK1 active drugs and 50 structurally similar compounds. These models can, thus, suggestively be recommended for virtual screening of JAK1‐selective candidates as a lead for immunomodulatory diseases like asthma.
Clinical and pathological characterization of FLNC‐related myofibrillar myopathy caused by founder variant c.8129G>A in Hong Kong Chinese
Authors: Lee Han‐Chih Hencher , Wong Shun , Sheng Bun , Pan Nin‐Yuan Keith , Leung Ying‐Kit Frank , Lau Kwok‐Kwong Dominic , Cheng Yue Sandy , Ho Luen‐Cheung , Li Richard , Lee Chi‐Nam , Tsoi Tak‐Hong , Cheung Yuk‐Fai Nelson , Fu Yat‐Pang Michael , Kan Nim‐Chi Amanda , Chu Yim‐Pui , Au Wing‐Chi Lisa , Yeung Hon‐Ming Jonas , Li Siu‐Hung , Cheung Chi‐Fung Mark , Tong Hok‐Fung , Hung Ling‐Yin Esther , Chan Tina Yee‐Ching , Li Chi Terence , Tong Tsz‐Yan Tammy , Tong Tin‐Wing Candy , Leung Ho‐Ying Cory , Lee Ka‐Ho , Yeung Sung‐Yan Sue , Lee Sau‐Yin Blanka , Lau Tze‐Chin Gene , Lam Ching‐Wan , Mak Chloe Miu , Chan Albert Yan‐Wo 
Published: February 2020

AbstractFLNC‐related myofibrillar myopathy could manifest as autosomal dominant late‐onset slowly progressive proximal muscle weakness; involvements of cardiac and/or respiratory functions are common. We describe 34 patients in nine families of FLNC‐related myofibrillar myopathy in Hong Kong ethnic Chinese diagnosed over the last 12 years, in whom the same pathogenic variant c.8129G>A (p.Trp2710*) was detected. Twenty‐six patients were symptomatic when diagnosed; four patients died of pneumonia and/or respiratory failure. Abnormal amorphous material or granulofilamentous masses were detected in half of the cases, with mitochondrial abnormalities noted in two‐thirds. We also show by haplotype analysis the founder effect associated with this Hong Kong variant, which might have occurred 42 to 71 generations ago or around Tang and Song dynasties, and underlain a higher incidence of myofibrillar myopathy among Hong Kong Chinese. The late‐onset nature and slowly progressive course of the highly penetrant condition could have significant impact on the family members, and an early diagnosis could benefit the whole family. Considering another neighboring founder variant in FLNC in German patients, we advocate development of specific therapies such as chaperone‐based or antisense oligonucleotide strategies for this particular type of myopathy.
Comparison of in‐situ bone ring technique and tent‐pole technique for horizontally deficient alveolar ridge in the anterior maxilla
Authors: Yuan Shuai , Mu Zhixiang , Huang Yuanding , Bai Shi , Xu Peng , Chen Tao 
Published: February 2020

AbstractBackgroundLimited studies focused on the bone profile maintenance at the alveolar ridge crest applying horizontal bone augmentation.PurposeA novel approach named as “in‐situ bone ring technique” was introduced to be compared with tent‐pole technique to evaluate their horizontal bone gain, resorption, and postoperative perception.Materials and methodsA total of 30 patients were included in this retrospective cohort study. All patients required horizontal bone augmentation at anterior site. Accordingly, quantitative and qualitative analyses were conduct radiographically and histologically between in‐situ bone ring (ring group) and tent‐pole technique (tent group). Moreover, the visual analog scale (VAS) was introduced to assess the patients' perception toward both treatments.ResultsCone‐beam computed tomography results showed great significant difference regarding horizontal bone width at 0 mm and 3 mm from alveolar ridge crest between two groups (P < .05). On the basis of histological outcomes, delightful bony fusion was shown 6‐month postoperatively in ring group. The VAS ratings for pain and swelling reflected similar results between two groups.ConclusionsIn‐situ bone ring technique evidently increased and maintained horizontal bone mass at the alveolar ridge crest compared to tent‐pole technique, which might be favorable for implant rehabilitation in anterior area. Meanwhile, no further discomfort was caused according to VAS scoring between two groups.