bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA Let-7i Is a Promising Serum Biomarker for Post-stroke Cognitive Impairment and Alleviated OGD-Induced Cell Damage in vitro by Regulating Bcl-2
Authors: Wang Zhan-Qiang , Li Kuo , Huang Jie , Huo Tian-Tian , Lv Pei-Yuan 
Published: March 2020

BackgroundThe mechanism of post-stroke cognitive impairment (PSCI) has not been explained. We aimed to investigate whether miR-let-7i participates in the PSCI and illuminates its underlying role in oxygen–glucose deprivation (OGD)-induced cell apoptosis.MethodsBlood samples from 36 subjects with PSCI and 38 with post-stroke cognitive normality (Non-PSCI) were collected to evaluate the differential expression of miR-let-7 family members, using qRT-PCT analysis. Spearman correlation was performed to estimate the correlation between the miR-1et-7i level and Montreal Cognitive Assessment (MoCA) score. Treatment of SH-SY5Y cells with OGD was used to induce cell apoptosis in vitro. Effects of miR-let-7i on OGD-induced cell apoptosis was estimated after transfection. The target gene of miR-let-7i was analyzed by dual luciferase reporter gene assay.ResultsThe expression of miR-let-7i was up-regulated in PSCI patients compared with Non-PSCI (p &lt; 0.001) and negatively correlated with MoCA score (r = −0.643, p &lt; 0.001). When exposed to OGD, SH-SY5Y cells showed significant apoptosis accompanied by miR-let-7i up-regulation. In OGD-treated cells, miR-let-7i up-regulation was accompanied by cell apoptosis, while down-regulation showed the opposite effect. Luciferase reporter assay showed that Bcl-2 was a target gene of miR-let-7i. Western blot showed that miR-let-7i up-regulation promoted Bcl-2 expression, while qRT-PCR showed that miR-let-7i had no effect on Bcl-2 expression.ConclusionmiR-let-7i was overexpressed in PSCI patients and it could be used as a diagnostic biomarker for PSCI. We illuminated the potential mechanism that miR-let-7i alleviated OGD-induced cell damage by targeting Bcl-2 at the post-transcriptional level.
KUALITAS PELAYANAN PUBLIK DI KANTOR DINAS KEPENDUDUKAN DAN CATATAN SIPIL KABUPATEN GORONTALO
Authors: Abdussamad Juriko 
Published: March 2020

ABSTRAK
Penelitin ini bertujuan untuk mengetahui gambaran secara deskriptif mengenai Pelayanan Publik dan Kualitas Pelayanan Publik di Kantor Dinas Kependudukan dan Catatan Sipil Kabupaten Gorontalo. Penelitian menunjukkan bahwa Kualitas Pelayanan Publik di Kantor Dinas Kependudukan dan Catatan Sipil Kabupaten Gorontalo masih belum baik, hal ini dapat dilihat melalui beberapa hal, seperti halnya upaya peningkatan profesionalisme aparatur yang masih kurang, melaksanakan pelayanan yang belum tepat waktu. Temuan dari penelitian menunjukkan ada dalam beberapa hal yang menyebabkan pelayanan yang masih kurang baik dari sisi profesionalisme aparatur dan ketepatan waktu dalam kerja. Kesemua hal ini perlu untuk diperbaiki dengan memperhatikan sisi kualifikasi aparatur dalam memberikan pelayanan. Baik dalam hal Reliability (Kehandalan), Responsivenees (Daya tanggap), dan Assurance (Jaminan). Faktor-faktor pendukung seperti Motivasi kerja dan Kerja sama. Faktor-faktor penghambat seperti Sumber Daya Manusia (SDM), Sarana dan Prasarana.
Kata Kunci: Pelayanan Publik, Kualitas, Public Services, Quality
EVALUASI PROGRAM PEMBELAJARAN MATEMATIKA DENGAN PENDEKATAN KIRKPATRICK
Authors: Damanik Rabukit 
Published: March 2020

Tujuan penelitian ini adalah untuk mengetahui: (1) makin tinggi penguasaan kompetensi pedagogik guru maka makin tinggi pula tingkat penguasaan reaksi siswa, belajar siswa, perilaku siswa, dan hasilnya; (2) makin tinggi penguasaan kompetensi profesional guru maka makin tinggi pula tingkat penguasaan reaksi siswa, belajar siswa, perilaku siswa, dan hasilnya. (3) makin tinggi penguasaan kompetensi pedagogik guru dan professional guru secara bersama-sama maka makin tinggi pula tingkat penguasaan reaksi siswa, belajar siswa, perilaku siswa, dan hasilnya. Metode penelitian ini adalah penelitian evaluasi dengan desain penelitian expost facto. Tujuan penelitian evaluasi adalah untuk mengukur efek program, yang dimaksudkan untuk memperbaiki program atau mengembangkan program yang akan datang, sebagai pranata untuk membuat keputusan yang akan datang tentang program tersebut. Populasi penelitian ini adalah guru dan siswa SMA Sub Rayon 3 Kota Medan, sebanyak 258 orang siswa dan 14 orang guru pada mata pelajaran matematika. Instrumen yang digunakan untuk mengumpulkan data ialah kuesioner skala Likert. Hasil penelitian ini menunjukkan bahwa: (1) makin tinggi penguasaan kompetensi pedagogic guru maka makin tinggi pula tingkat penguasaan reaksi siswa, belajar siswa, perilaku siswa, dan hasilnya; (2) bila ubahan kompetensi pedagogik dan kompetensi profesional dikendalikan maka tingkat penguasaan reaksi dan perilaku yang signifikan sedangkan belajar dan hasil tidak signifikan; dan (3) ubahan kanonis bebas (kompetensi pedagogic dan kompetensi professional berpengaruh terhadap reaksi (dengan muatan kanonis 0,99), terhadap belajar (dengan muatan kanonis 0,09), terhadap perilaku (dengan muatan kanonis 0,59), dan terhadap hasil (dengan muatan kanonis 0,19).
PENGARUH MODEL KOOPERATIF TIPE EXAMPLE NON EXAMPLE TERHADAP KEMAMPUAN MENULIS PUISI OLEH SISWA KELAS VIII MTs BINAUL IMAN KARANG SARI
Authors: Marini Netti , Lubis Fheti Wulandari 
Published: March 2020

Penelitian ini bertujuan untuk menjelaskan bagaimana pengaruh model pembelajaran kooperatif tipe example non example terhadap kemampuan menulis puisi siswa. Adapun teknik pengumpulan data pada penelitian ini berbentuk essay test dan teknik pengolahan data yang digunakan dalam penelitian ini adalah analisis korelasi pearson product moment.Hasil penelitian menunjukkan bahwa ada peningkatan nilai pada kemampuan menulis puisi saat dilaksanakannya pre-test dan post-tes. Nilai rata-rata yang diperoleh saat dilaksanakan pre-test kemampuan siswa dalam menulis puisi adalah 65,48 dan nilai rata-rata yang diperoleh saat dilaksanakan post-test kemampuan siswa dalam menulis puisi adalah 87,91. Diketahui dk =n-2 =60-2=58. Untuk penelitian taraf nyata yang dipakai adalah α = 0,5. Nilai determinasi adalah 36% dari perhitungan analisis korelasi diperoleh nilai koofisien korelasi (r) = 0,60 yang digolongkan pada tingkat korelasi sedang. Hasil korelasi tersebut dilanjutkan dengan uji “t” dan diperoleh hasil t hitung sebesar 5,70 sedangkan hasil t tabel sebesar 2,021, maka hipotesis alternatif (Ha) diterima dan hipotesis nol (Ho) ditolak. Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa ada pengaruh model kooperatif tipe example non example terhadap kemampuan menulis puisi siswa kelas VIII MTs Binaul Iman Karang Sari.
PENGARUH BIMBINGANKELOMPOK TERHADAP PERKEMBANGAN KONSEP DIRI POSITIF SISWA DI SMKS-PP SWASTA PUTRA JAYA STABAT KABUPATEN LANGKAT TAHUN PELAJARAN 2016/2017
Authors: MA Hadi Widodo 
Published: March 2020

Penelitian ini dilaksankan di SMKS Swasta PP Putra Jaya Stabat tahun pelajaran 2016/2017. Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh bimbingan kelompok terhadap konsep diri positif siswa di SMKS Swasta Putra Jaya Stabat.Sampel yang digunakan berjumlah 32 siswa kelas XI yang terbagi menjadi dua kelompok yang masing-masing terdiri dari 16 siswa. Hasil penelitian menunjukkan bahwa ada perbedaan konsep diri sebelum dan sesudah diberikan bimbingan kelompok pada siswa SMKS Swasta PP Putra Jaya Stabat yang ditunjukkan dengan hasil nilai t hitung lebih besar dari t tabel (2,798 > 2,131) pada signifikansi 5%, Dengan demikian hipotesis yang terdapat pengaruh antara bimbingan kelompok terhadap perkembangan konsep diri positif siswa di SMKS Swasta Putra Jaya Stabat diterima. Jadi dapat disimpulkan bahwa hasil postest eksperimen lebih besar daripada postest kontrol. Semakin sering dan aktif dalam melakukan bimbingan kelompok maka semakin meningkat konsep diri positif siswa.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE SNOWBALL TROWING DALAM MENINGKATKAN HASIL BELAJAR GEOGRAFI PADA MATERI SEBARAN FLORA DAN FAUNA DI INDONESIA KELAS XI IPS-2 SMA NEGERI 5 BINJAI TAHUN PELAJARAN 2014/2015
Authors: Suryati Suryati Suryati 
Published: March 2020

Tujuan yang akan dicapai dalam Penelitian Tindakan Kelas ini adalah: “Untuk mengetahui pengaruh penerapan model pembelajaran kooperatif tipe Snowball Trowing dalam meningkatkan hasil belajar geografi pada materi sebaran flora dan fauna di Indonesia kelas XI IPS-2 SMA Negeri 5 Binjai Semeter I Tahun Pelajaran 2014/2015. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Prosedur tindakan kelas (PTK) merupakan penelitian dengan menggunakan proses pengkajian melalui system berdaur (siklus) dari berbagai kegiatan pembelajaran. Siklus yang dimaksud melalui tahap perencanaan, tindakan, observasi, dan refleksi. Untuk penelitian ini direncanakan sampai 2 siklus. Berdasarkan hasil diskusi dengan pengawas maka pembelajaran yang dilaksanakan sudah menunjukkan kemajuan. Hal ini ditunjukkan dengan adanya keberhasilan siswa yang dapat menguasai pelajaran Geografi pada materi persebaran flora fauna di indonesia dimana hasil yang diperoleh adalah 87,5% tuntas dalam pembelajaran lebih dari 75% yaitu 87,5% pada siklus II. Disamping itu juga terdapat kemajuan dalam hal prestasi belajar dimana nilai siswa dari pra siklus ke siklus I, dan dari siklus ke Siklus II. Kata Kunci: model pembelajaran kooperatif tipe snowball trowing, hasil belajar geografi, sebaran flora dan fauna
DETERMINANT OF HUMAN DEVELOPMENT INDEX IN SOUTHEAST ASIA
Authors: Handalani Radite Teguh 
Published: March 2020

ABSTRAK
Penelitian ini bertujuan menganalisis indeks pembangunan manusia yang bersifat multidimensional dan kompleks, mencakup aspek ekonomi, aspek tata kelola pemerintahan dan aspek demografi yang diwakili oleh 13 variabel independen di 10 negara di Asia Tenggara. Namun, upaya tersebut seringkali terkendala oleh ketidaklengkapan data dan keandalan data. Berbeda dengan beberapa penelitian terdahulu yang lebih memfokuskan aspek pembangunan manusia pada variabel pembentuk human development index seperti angka harapan hidup, angka melek huruf dan literasi serta angka rerata akses lamanya menempuh pendidikan atau variabel-variabel independen aspek ekonomi. Penelitian ini memasukan aspek tata kelola pemerintahan dan aspek kependudukan yang diharapkan dapat melengkapi spektrum dan kajian terhadap aspek pembangunan manusia. Metode yang digunakan dalam penelitian ini menggunakan analisis regresi data panel (pooled least squares) dan serangkaian pengujian untuk menghasilkan spesifikasi model dan estimator terbaik. Dalam penelitian yang menggunakan tingkat keyakinan sebesar 95% pada p-value pada nilai α=0,05 ditemukan bahwa dari 13 variabel hanya terdapat 5 (lima) variabel yang berpengaruh signifikan terhadap peningkatan indeks pembangunan manusia.

Kata kunci: Indeks pembangunan manusia, tata kelola pemerintahan, demografi

ABSTRACT
This study aims to analyze the human development index that is multidimensional and complex which includes economic, governance and demographic aspects represented by 13 independent variables in 10 countries of Southeast Asia. However, these efforts are often constrained by incomplete data and data reliability. Unlike some previous studies which focused more on the variables forming the human development index, such as life expectancy, literacy rates and the average number of years of education or independent variables of economic aspects. This research includes aspects of governance and population aspects that are expected to complement the spectrum and study of aspects of human development. The method used in this study uses pooled least squares. In research that uses a 95% confidence level, it was found that from 13 variables there are only five variables that significantly influence increasing human development index.

Keywords: human development index, governance, demografi
Gravity-dominated Collisions: A Model for the Largest Remnant Masses with Treatment for “Hit and Run” and Density Stratification
Authors: Gabriel Travis S. J. , Jackson Alan P. , Asphaug Erik , Reufer Andreas , Jutzi Martin , Benz Willy 
Published: March 2020

Abstract
We develop empirical relationships for the accretion and erosion of colliding gravity-dominated bodies of various compositions under conditions expected in late-stage solar system formation. These are fast, easily coded relationships based on a large database of smoothed particle hydrodynamics (SPH) simulations of collisions between bodies of different compositions, including those that are water rich. The accuracy of these relations is also comparable to the deviations of results between different SPH codes and initial thermal/rotational conditions. We illustrate the paucity of disruptive collisions between major bodies, as compared to collisions between less massive planetesimals in late-stage planet formation, and thus focus on more probable, low-velocity collisions, though our relations remain relevant to disruptive collisions as well. We also pay particular attention to the transition zone between merging collisions and those where the impactor does not merge with the target, but continues downrange, a “hit-and-run” collision. We find that hit-and-run collisions likely occur more often in density-stratified bodies and across a wider range of impact angles than suggested by the most commonly used analytic approximation. We also identify a possible transitional zone in gravity-dominated collisions where larger bodies may undergo more disruptive collisions when the impact velocity exceeds the sound speed, though understanding this transition warrants further study. Our results are contrary to the commonly assumed invariance of total mass (scale), density structure, and material composition on the largest remnants of giant impacts. We provide an algorithm for adopting our model into N-body planet formation simulations, so that the mass of growing planets and debris can be tracked.
The Proper Motion of Sagittarius A*. III. The Case for a Supermassive Black Hole
Authors: Reid M. J. , Brunthaler A. 
Published: March 2020

Abstract
We report measurements with the Very Long Baseline Array of the proper motion of Sgr A* relative to two extragalactic radio sources spanning 18 yr. The apparent motion of Sgr A* is −6.411 ± 0.008 mas yr−1 along the Galactic plane and −0.219 ± 0.007 mas yr−1 toward the North Galactic Pole. This apparent motion can almost entirely be attributed to the effects of the Sun’s orbit about the Galactic center. Removing these effects yields residuals of −0.58 ± 2.23 km s−1 in the direction of Galactic rotation and −0.85 ± 0.75 km s−1 toward the North Galactic Pole. A maximum-likelihood analysis of the motion, both in the Galactic plane and perpendicular to it, expected for a massive object within the Galactic center stellar cluster indicates that the radiative source, Sgr A*, contains more than about 25% of the gravitational mass of 4 × 106

deduced from stellar orbits. The intrinsic size of Sgr A* is comparable to its Schwarzschild radius, and the implied mass density of

pc−3 is very close to that expected for a black hole, providing overwhelming evidence that it is indeed a supermassive black hole. Finally, “intermediate mass” black holes more massive than ≈3 × 104

between approximately 0.003 and 0.1 pc from Sgr A* are excluded.
Properties of Trans-fast Magnetosonic Jets in Black Hole Magnetospheres
Authors: Pu Hung-Yi , Takahashi Masaaki 
Published: March 2020

Abstract
Traveling across several orders of magnitude in distance, relativistic jets from strong gravity regions to asymptotic flat spacetime regions are believed to consist of several general relativistic magnetohydrodynamic (GRMHD) processes. We present a semianalytical approach for modeling the global structures of a trans-fast magnetosonic relativistic jet, which should be ejected from a plasma source near a black hole in a funnel region enclosed by dense accreting flow and a disk corona around the black hole. Our model consistently includes the inflow and outflow part of the GRMHD solution along the magnetic field lines penetrating the black hole horizon. After the rotational energy of the black hole is extracted electromagnetically by the negative energy GRMHD inflow, the huge electromagnetic energy flux propagates from the inflow to the outflow region across the plasma source, and in the outflow region, the electromagnetic energy converts to the fluid kinetic energy. Eventually, the accelerated outflow must exceed the fast magnetosonic wave speed. We apply the semianalytical trans-fast magnetosonic flow model to the black hole magnetosphere for both parabolic and split-monopole magnetic field configurations and discuss the general flow properties, that is, jet acceleration, jet magnetization, and the locations of some characteristic surfaces of the black hole magnetosphere. We have confirmed that, at large distances, the GRMHD jet solutions are in good agreement with the previously known trans-fast special relativistic magnetohydrodynamic jet properties, as expected. The flexibility of the model provides a prompt and heuristic way to approximate the global GRMHD trans-fast magnetosonic jet properties.
Making a Supermassive Star by Stellar Bombardment
Authors: Tagawa Hiromichi , Haiman Zoltan , Kocsis Bence 
Published: March 2020

Abstract
Approximately 200 supermassive black holes (SMBHs) have been discovered within the first ∼gigayear after the Big Bang. One pathway for the formation of SMBHs is through the collapse of supermassive stars (SMSs). A possible obstacle to this scenario is that the collapsing gas fragments and forms a cluster of main-sequence stars. Here, we raise the possibility that stellar collisions may be sufficiently frequent and energetic to inhibit the contraction of the massive protostar, avoiding strong UV radiation driven outflows, and allowing it to continue growing into an SMS. We investigate this scenario with semianalytic models incorporating star formation; gas accretion; dynamical friction from stars and gas; stellar collisions; and gas ejection. We find that when the collapsing gas fragments at a density of ≲3 × 1010 cm−3, the central protostar contracts due to infrequent stellar mergers, and in turn photoevaporates the remaining collapsing gas, resulting in the formation of a ≲104
M
⊙ object. On the other hand, when the collapsing gas fragments at higher densities (expected for a metal-poor cloud with Z ≲ 10−5
Z
⊙ with suppressed H2 abundance) the central protostar avoids contraction and keeps growing via frequent stellar mergers, reaching masses as high as ∼105–106
M
⊙. We conclude that frequent stellar mergers represent a possible pathway to form massive BHs in the early universe.
A Toy Model for the Electromagnetic Output of Neutron-star Merger Prompt Collapse to a Black Hole: Magnetized Neutron-star Collisions
Authors: Nathanail Antonios 
Published: March 2020

Abstract
We present a systematic study of magnetized neutron star head-on collisions. We investigate the resulting magnetic field geometries as the two neutron stars merge. Furthermore, we analyze the luminosity produced in these collisions and monitor the evolution of the magnetic fields from the time of merger until the subsequent production of a black hole. At the time of black hole formation, the luminosity peaks and rings down following the decay of the electromagnetic fields. A comparison is presented for three different cases: one where the initial magnetic field in both neutron stars is aligned, one where they are anti-aligned, and one where they initially have unequal magnetic field strength. We identify regions and set limits so that pair creation and magnetic reconnection would occur in this scenario and further discuss limits and differences in the radiated energy. This study should be regarded as a toy model of the case where the remnant of a binary neutron star merger undergoes a prompt collapse to a black hole with a negligible surrounding disk. We note that the generated electromagnetic pulses resemble the fast radio burst phenomenology. We consider implications of the high-mass mergers leading to a fast prompt collapse to a black hole and the expected flux to be observed at a distance similar to the binary neutron star gravitational wave detection GW190425.
Stellar-mass Measurements in A133 with Magellan/IMACS
Authors: Starikova S. , Vikhlinin A. , Kravtsov A. , Kraft R. , Connor T. , Mulchaey J. S. , Nagai D. 
Published: March 2020

Abstract
We present the analysis of deep optical imaging of the galaxy cluster A133 with the IMACS instrument on Magellan. Our multi-band photometry enables stellar-mass measurements in the cluster member galaxies down to a mass limit of

(≈0.1 of the Large Magellanic Cloud stellar mass). We observe a clear difference in the spatial distribution of large and dwarf galaxies within the cluster. Modeling these galaxy populations separately, we can confidently track the distribution of stellar mass locked in the galaxies to the cluster’s virial radius. The extended envelope of the cluster’s brightest galaxy can be tracked to ∼200 kpc. The central galaxy contributes ∼1/3 of the total cluster stellar mass within the radius

.
La régulation du travail des chauffeurs de VTC : disruption et résistance par la voie du droit
Authors: Carelli Rodrigo , Kesselman Donna 
Published: March 2020

Le bouleversement de la régulation du travail, par le recours à une main-d’œuvre sans lien d’emploi direct avec l’entreprise, se trouve au cœur du modèle d’affaires du capitalisme de plateforme. Partout, la nature de la relation entre les plateformes de VTC et les chauffeurs est contestée et se trouve au cœur des conflits juridiques et administratifs. Partout, le pouvoir judicaire joue un rôle clé dans la qualification de la nature de la prestation du service comme celle du « prestataire du service », à savoir, le chauffeur.
Effectiveness of a Leadership Development Course for Chief Residents: A Longitudinal Evaluation
Authors: Mustafa Sultana , Stoller James K. , Bierer S. Beth , Farver Carol F. 
Published: March 2020

ABSTRACT

Background
Nonclinical skills (eg, self-regulation, team leadership, conflict resolution) are essential for success as a chief resident (CR). The literature on programs teaching these skills reports few if any effectiveness outcomes.

Objective
We reported the outcomes of a leadership course for CRs using participants' self-reported outcomes and assessments from their program directors (PDs).

Methods
A 2-day curriculum focused on emotional intelligence competencies, including self-awareness, self-management, social awareness, and relationship management. We used a logic model to align 2017–2018 curriculum with targeted outcomes. Questionnaires before and after the course assessed short-term and intermediate outcomes for the participants and PD interviews evaluated observed changes in CRs' performance attributable to the course.

Results
A total of 74 residents participated in the course, and 65% and 59% responded to the post-course and follow-up questionnaires, respectively. Over 95% of respondents indicated developing leadership knowledge and skills and connecting with new CRs in the post-course questionnaire. During follow-up, CRs reported applying concepts learned during chief residency, using tools to address conflict, engaging in quality and patient safety projects, and continuing to interact with other participants. The relationships between reported outcomes and participants' gender/prior leadership training were not significant (P &gt; .05), with small to medium effect sizes (0.01–0.32). All 14 PDs offered positive appraisal of the CRs, but we could not specifically attribute this growth to the course.

Conclusions
Participation in this CR leadership development course was associated with enhancement and application of leadership competencies in immediate and intermediate time frames.