bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selbstverständnis der klassischen Naturheilverfahren
Authors: Stange Rainer 
Published: December 2019

SummaryDie klassischen Naturheilverfahren betrachten sich alsfester Bestandteil der Medizin: Sie werden im Medizinstudiumals prüfungsrelevantes Wissen angeführt undzusätzlich als ärztlicheWeiterbildung für die Zusatzbezeichnung „Naturheilverfahren“ angeboten. Es handeltsich um einetraditionsreiche, gut regulierte und erfolgreicheärztliche Spezialisierung. Vermutlich hält sie aucheiner kritischen Überprüfung stand, diese wird allerdingskaum angestrengt.Vor dem Hintergrundverschiedener, pragmatisch geprägterund nicht ausdiskutierter Begrifflichkeiten wieKomplementärmedizin lässt sich konstatieren: Naturheilverfahrenverstehen sich explizit durch dieTherapieauswahlkriterienwie beanspruchte Wirkmechanismen undnicht relational zu einer wieauch immer gewähntenMainstream-Medizin.
3D printing of fillable individual thyroid replicas based on nuclear medicine DICOM data used as phantoms for gamma probe calibration
Authors: Kühnel Christian , Seifert Philipp , Mulik Christina , Winkens Thomas , Freesmeyer Martin 
Published: December 2019

Abstract
Aim To proof the feasibility of manufacturing patient-indivdual (anthropomorphic) thyroid replicas from I-124 PET DICOM datasets by means of 3D printing. A possible field of application is the use of those phantoms for the calibration of gamma probes.
Methods After editing of the DICOM datasets using several software types and transferring into a dedicated stereolithography format, 10 fillable thyroid replicas (35–200 mL) made of polylactide acid were manufactured via 3D printing. All replicas were filled with a water-solution containing 3.5 MBq I-131 and applied to a standard neck phantom. Calibration factor measurements were carried out using a clinical gamma probe. Measurements were performed with three different tilts: + 15°, 0° and –15°. The influence of the replicas’ volume and the tilt was investigated.
Results Manufacturing of the replicas was successful in all cases. The time required for data processing was 13 ± 2 (median: 12, range: 9–25) min and 4–11 h for 3D printing (size-dependent). The printing process could be done overnight. Measured mean calibration factor for straight gamma probe positioning (0° tilt) was 31 965 ± 3360 (33 893, 25 470–34 253) cpm/MBq. A tilt of –15° resulted in lower calibration factors (–7.7 %), whereas a tilt of + 15° led to higher values (+ 9.5 %); p = 0.001. The calibration factors were highly inversely proportional correlated to the volume of the replicas (r = –0.91, p < 0.001).
Conclusion 3D printing of patient-individual (anthropomorphic) fillable thyroid replicas was feasable for a large range of volumes. The study demonstrates the influence of the volume as well as the tilt of the measured object for calibration factor measurements with gamma probes.
Panorama da infiltração para ombro doloroso entre especialistas em ombro
Authors: Lara Paulo Henrique Schmidt , Pereira Vitor Luis , Júnior Ronaldo Roncetti , Ribeiro Leandro Masini , Ejnisman Benno , Belangero Paulo Santoro 
Published: December 2019

Resumo
Objetivo Avaliar como especialistas de ombro têm utilizado a infiltração na sua prática diária.
Métodos Estudo tipo survey interseccional em tempo único, no qual especialistas em ombro e cotovelo responderam a um questionário sobre o uso de infiltrações no ombro doloroso.
Resultados A maior parte (45,9%) dos entrevistados possui experiência > 10 anos na área e realizaram até 10 infiltrações nos últimos 12 meses. As principais indicações para infiltração glenoumeral e subacromial são artrose glenoumeral e tendinopatia do manguito rotador, respectivamente. Os portais mais utilizados são o posterior (52,2%) para infiltração glenoumeral e o lateral (57,5%) na subacromial. A maioria (75,2%) dos entrevistados realiza a infiltração ambulatorialmente sem auxílio de métodos de imagem, e a droga mais utilizada é a combinação de corticoide e anestésico. A principal contraindicação citada é a presença de diabetes, e a complicação mais comum é a dor após a infiltração.
Conclusão Infiltrações subacromiais são indicadas especialmente para tratamento de tendinopatias do manguito e bursites, realizadas pelo portal lateral, em ambiente ambulatorial, com baixo índice de complicações em longo prazo. As infiltrações glenoumerais são indicadas especialmente para artrose glenoumeral, com combinação de corticoide e anestésico, realizadas, em sua maioria, ambulatorialmente.
O padrão da rotura do supraespinal afeta os resultados do reparo artroscópico?
Authors: Malavolta Eduardo Angeli , Andrade-Silva Fernando Brandão , Canhos André Lange , Assunção Jorge Henrique , Gracitelli Mauro Emilio Conforto , Ferreira Neto Arnaldo Amado 
Published: December 2019

Resumo
Objetivo Avaliar a influência do padrão da rotura do supraespinal nas avaliações funcionais pré e pós-operatória.
Métodos Estudo de coorte retrospectivo, comparando pacientes com rotura do supraespinal em crescente versus em L ou U. Incluímos pacientes submetidos ao reparo artroscópico completo do supraespinal. Não incluímos pacientes com reparo dos tendões do subescapular ou infraespinal, aqueles submetidos a cirurgia aberta, ou aqueles nos quais foi obtido apenas o reparo parcial. As escalas clínicas utilizadas foram The American Shoulder and Elbow Surgeons Standardized Shoulder Assessment (ASES) e Modified-University of California at Los Angeles Shoulder Rating Scale (UCLA), aplicadas uma semana antes e 24 meses após o procedimento.
Resultados Analisamos 167 ombros (de 163 pacientes). No pré-operatório, a escala da ASES demonstrou ser significativamente superior no padrão em crescente (43,5 ± 17,6 versus 37,7 ± 13,8; p = 0,034). A escala da UCLA teve o mesmo padrão (15,2 ± 4,6 versus 13,5 ± 3,6; p = 0,028). No pós-operatório, entretanto, não ocorreu diferença significativa. De acordo com a escala da ASES, roturas em crescente tiveram 83,7 ± 18,7 pontos, e as roturas em L ou U, 82,9 ± 20,1 (p = 0,887). Respectivamente, os valores foram de 30,9 ± 4,9 e 30,5 ± 5,6 (p = 0,773) pela escala da UCLA.
Conclusão As roturas em crescente e em L ou U do supraespinal apresentam resultados funcionais pós-operatórios semelhantes. No pré-operatório, os resultados funcionais são superiores nas roturas em crescente.
Nível de evidência e patrocínio industrial associado a desfechos favoráveis nas publicações sobre terapia com plasma rico em plaquetas nas doenças osteomusculares
Authors: Nesello Pietro Felice Tomazini , Baroni Allan Cassio , Selistre Luciano da Silva 
Published: December 2019

ResumoO plasma rico em plaquetas é derivado da centrifugação do sangue total. Há um interesse crescente, na medicina esportiva e na comunidade atlética, no fornecimento de fatores de crescimento endógeno diretamente ao sítio da lesão, usando componentes sanguíneos autólogos, como o plasma rico em plaquetas. O objetivo deste estudo é avaliar a associação entre financiamento de pesquisa, conflito de interesses, nível de evidência e afiliação dos autores com a interpretação dos resultados em publicações sobre terapia com plasma rico em plaquetas nas doenças osteomusculares. Foi realizada uma revisão da literatura atual. O desfecho foi classificado como favorável ou desfavorável. A declaração de conflito de interesses e o tipo de financiamento foram extraídos de cada artigo. O financiamento foi qualificado em patrocínio industrial; não patrocinado pela indústria; ou não identificável. O nível de evidência foi categorizado de I a IV. Foram obtidos os resultados positivos mais altos com 134 estudos financiados pelo setor industrial, em comparação com estudos não financiados pela indústria (razão de probabilidades [RP]: 0,26; intervalo de confiança de 95% [95%IC]: 0,08–0,85; p < 0,05). Em comparação com o nível de evidência I, os níveis II e IV aumentam a probabilidade de resultado positivo em 12,42 vezes (p < 0,01) e 10,97 vezes (p < 0,01), respectivamente. Demonstrou-se que, proporcionalmente, estudos patrocinados pela indústria têm maior probabilidade de apresentar resultados positivos, bem como artigos com menor qualidade de evidência.
Brain Crosstalk with Other Organs in ICU Patient
Authors: Saran Sai , Gurjar Mohan 
Published: December 2019

AbstractCrosstalk between various organs exists in the human body. This can be part of physiological reflexes such as cardiac reflexes that protect the organs during stressful stimuli or can be part of pathological conditions where an insult to an organ releases cytokines that cause distant effects on other organs. In critically ill patients, these crosstalks are independent of pre-existing common risk factors or the presence of new risk exposure during the treatment. Crosstalk can manifest in series or parallel. The human brain, being a control center of the human body, does crosstalk with almost every organ in the body. In this narrative review, crosstalk of the brain with various organs and systems such as the heart, lungs, liver, kidneys, gut, muscle, bone, skin, adipose tissue, and immune system is being discussed along with clinical manifestations and management. Future research might help to target these pathological processes in preventing progression of single-organ dysfunction to multi-organ failures in critically ill patients.
Effect of Testosterone on Proliferation Markers and Apoptosis in Breasts of Ovariectomized Rats
Authors: Oliveira Jussara Celi Conceição , Steiner Marcelo Luis , Theodoro Thérèse Rachell , Mader Ana Maria Amaral Antonio , Petri Giuliana , Abreu Luiz Carlos , Pinhal Maria Aparecida da Silva , Fernandes César Eduardo , Pompei Luciano Melo 
Published: December 2019

Abstract
Objective To investigate the action of testosterone (T), isolated or associated with estradiol benzoate (EB), on the proliferation markers and apoptosis of breasts of ovariectomized rats.
Methods A total of 48 castrated female Wistar rats were divided into 6 groups, and each of them were submitted to one of the following treatments for 5 weeks: 1) control; 2) EB 50 mcg/day  + T 50 mcg/day; 3) T 50mcg/day; 4) EB 50 mcg + T 300 mcg/day; 5) T 300 mcg/day; and 6) EB 50 mcg/day. After the treatment, the mammary tissue was submitted to a histological analysis and immunoexpression evaluation of proliferation markers (proliferating cell nuclear antigen, PCNA) and apoptosis (caspase-3).
Results There was a statistically significant difference among the groups regarding microcalcifications and secretory activity, with higher prevalence in the groups treated with EB. There was no difference among the groups regarding atrophy, but a higher prevalence of atrophy was found in the groups that received T versus those that received EB + T. There was a difference among the groups regarding the PCNA (p = 0.028), with higher expression in the group submitted to EB + T 300 mcg/day. Regarding caspase-3, there was no difference among the groups; however, in the group submitted to EB + T 300 mcg/day, the expression was higher than in the isolated T group.
Conclusion Isolated T did not have a proliferative effect on the mammary tissue, contrary to EB. Testosterone in combination with EB may or may not decrease the proliferation, depending on the dose of T.
Resultados da artroplastia total de disco cervical com acompanhamento mínimo de 10 anos
Authors: Lobo João Pedro Ferraz Montenegro , Linhares Daniela Vilas Boas Rosa , Lopes José Miguel Monteiro , Rodrigues Pedro Cacho , Pinto Rui Peixoto , Neves Nuno Silva Morais 
Published: December 2019

Resumo
Objetivo No presente estudo, apresentamos os resultados com um acompanhamento mínimo de 10 anos da artroplastia total do disco cervical (ATDC) em um nível.
Métodos Estudo retrospectivo de pacientes submetidos a ATDC em um nível. Os resultados clínicos incluíram o índice de incapacidade relacionada ao pescoço (IIRP) e a escala visual analógica (EVA) no período pré-operatório, um ano pós-operatório e um mínimo de 10 anos de acompanhamento. Os parâmetros radiográficos incluíram a mobilidade cervical, lordose segmentar, ângulo C2-C7, ossificação heterotópica (OH), degeneração facetária e articular (DFA) e doença do segmento adjacente (DSA).
Resultados Identificados 22 pacientes, 16 mulheres e 6 homens com média de idade de 39,7 anos (26–51 anos), dos quais 15 tiveram um acompanhamento mínimo de 10 anos. Foi verificada melhoria estatisticamente significativa do IIRP e EVA (p < 0,001) entre pré-operatório e pós-operatório. (1 ano ou > 10 anos). Ao final de 10 anos, OH foi observada em 59% dos casos. A mobilidade do implante foi preservada em 80% dos pacientes. Houve evidência radiológica de DSA em 6 pacientes (40%). Não houve correlação entre os parâmetros clínicos avaliados e a presença de DSA ou as diferentes classes de OH.
Conclusão Melhoria clínica em todos os parâmetros avaliados, que persiste ao longo do tempo. A maioria dos implantes manteve a mobilidade, como já demonstrado em estudos anteriores com acompanhamentos mais curtos. Numa percentagem significativa, a DSA estava presente, questionando o conceito da tecnologia de preservação de movimento. No entanto, sem nenhuma intervenção cirúrgica por esse motivo, uma vez que não houve correlação com piores resultados clínicos.
Use of Augmented Reality in Reconstructive Microsurgery: A Systematic Review and Development of the Augmented Reality Microsurgery Score
Authors: Al Omran Yasser , Abdall-Razak Ali , Sohrabi Catrin , Borg Tiffanie-Marie , Nadama Hayat , Ghassemi Nader , Oo Khine , Ghanem Ali M. 
Published: December 2019

Abstract
Background Augmented reality (AR) uses a set of technologies that overlays digital information into the real world, giving the user access to both digital and real-world environments in congruity. AR may be specifically fruitful in reconstructive microsurgery due to the dynamic nature of surgeries performed and the small structures encountered in these operations. The aim of this study was to conduct a high-quality preferred reporting items for systematic reviews and meta-analyses (PRISMA) and assessment of multiple systematic reviews 2 (AMSTAR 2) compliant systematic review evaluating the use of AR in reconstructive microsurgery.
Methods A systematic literature search of Medline, EMBASE, and Web of Science databases was performed using appropriate search terms to identify all applications of AR in reconstructive microsurgery from inception to December 2018. Articles that did not meet the objectives of the study were excluded. A qualitative synthesis was performed of those articles that met the inclusion criteria.
Results A total of 686 articles were identified from title and abstract review. Five studies met the inclusion criteria. Three of the studies used head-mounted displays, one study used a display monitor, and one study demonstrated AR using spatial navigation technology. The augmented reality microsurgery score was developed and applied to each of the AR technologies and scores ranged from 8 to 12.
Conclusion Although higher quality studies reviewing the use of AR in reconstructive microsurgery is needed, the feasibility of AR in reconstructive microsurgery has been demonstrated across different subspecialties of plastic surgery. AR applications, that are reproducible, user-friendly, and have clear benefit to the surgeon and patient, have the greatest potential utility. Further research is required to validate its use and overcome the barriers to its implementation.
Homogenization of Kirchhoff plates with oscillating edges and point supports
Authors: Nazarov S. A. 
Published: December 2019

Abstract
We study deformations of a long (narrow after rescaling) Kirchhoff plate with periodic (rapidly oscillating) boundary. We deduce a limiting system of two ordinary differential equations of orders 4 and 2 which describe the deflection and torsion of a two-dimensional plate in the leading order. We also consider point supports (Sobolev conditions) whose configuration influences the result of homogenizing the biharmonic equation by decreasing the size of the limiting system of differential equations or completely eliminating it. The boundary-layer phenomenon near the end faces of the plate is studied for various ways of fastening as well as for angular junctions of two long plates, possibly by point clamps (Sobolev conjugation conditions). We discuss full asymptotic series for solutions of static problems and the spectral problems of plate oscillations.
Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected
Authors: Liu Cailing , Miyajima Taiga , Melangath Geetha , Miyai Takashi , Vasanth Shivakumar , Deshpande Neha , Kumar Varun , Ong Tone Stephan , Gupta Reena , Zhu Shan , Vojnovic Dijana , Chen Yuming , Rogan Eleanor G. , Mondal Bodhiswatta , Zahid Muhammad , Jurkunas Ula V. 
Published: December 2019

Significance
FECD is a genetic and female-predominant disorder which is the leading cause of corneal transplantation worldwide. There are no pharmacologic treatments for FECD; thus, there is a significant unmet need to improve the understanding of female prevalence in FECD pathogenesis. Herein, we reveal a physiologically relevant mechanism of UVA light causing DNA damage and inducing FECD, where greater DNA damage correlates with more severe FECD phenotype in females. Importantly, the sex-dependent effect of UVA is driven by the activation of CYP1B1, an enzyme which converts estrogen into metabolites that cause DNA damage. This study demonstrates an in vivo FECD model based on CE susceptibility to oxidative stress; furthermore, an antioxidant, NAC, restores UVA-induced changes, providing a potential therapeutic target.
The role of Ulama (Islamic religious leaders) in countering anti-vaccination rhetoric in Indonesia
Authors: Arief N. Nurlaela , Karlinah Siti 
Published: December 2019

Abstract
Indonesia has been facing a serious threat from fake news and hate speech which is wildly disseminated through
social media. As the largest Muslim-majority country in the world, health issues and their link to religion are one of the most
discussed topics on social media in this country. The aim of this study is to introduce a strategy to counterbalance fake news on
vaccine issues. This research employed a mixed-method approach that used content of analysis data obtained from social media
monitoring. In addition, semi-structured interviews were conducted with 15 participants from various sectors related to vaccine
issues. Monitoring of six female Facebook users in anti-vaccine groups revealed that the top five topics discussed in Indonesia
were halal certification, conspiracy, adverse effects, adjuvants, and vaccine substitution. This research
recommends a communication strategy to counterbalance fake news on the vaccine, employing both medical professionals and trusted,
influential members of the religious community to educate the public. They should have a strong background in medical issues and
understand Islamic perspectives. The involvement of Ulama (Islamic religious leaders) is important and needed to
explain that vaccines do not violate religious law.
Two types of aa3-nominals in Cantonese
Authors: Sio Joanna Ut-Seong , Tang Sze-Wing 
Published: December 2019

Abstract
This paper provides an overview of the grammatical properties of the Cantonese aa3, a nominal
element that only attaches itself to [+human] nouns. We provide evidence to show that there are in fact two types of
aa3-nominals. Their syntactic and semantic properties correlate with the number of syllables they consist of.
There is a two-way split between disyllabic aa3-nominals and multisyllabic aa3-nominals.
Aa3 in disyllabic aa3-nominals should be treated as a prosodic template filler while
aa3 in multisyllabic aa3-nominals occupies a syntactic position in the referential layer of
the Chinese nominal.
Optical Activity Effect on Planar Chiral Metamaterials
Authors: Partini Juliasih , Widiatmono Restu 
Published: December 2019

Abstract
Metamaterial is an artificial material which has a negative refractive index. Both of permitivitty and permeability have a negative value to possess negative refraction. The breakthrough of metamaterial development was present as the invention of planar chiral metamaterials. This research was focussed on the development of a new design of planar chiral metamaterial with different depth. The developed metamaterial design was analyzed by chirality analysis in relation to the optical activity characteristics.
The planar chiral metamaterial development was following a design, a structure examination, and a fabrication process using a focused ion beam system. Chirality characterization were measured using a femtosecond Ti:Sapphire pumped terahertz emission spectroscopy system. THz signal was occurred due to the optical rectification process as a result of an intense femtosecond laser pulses radiation on planar chiral metamaterial sample. The samples were capable to generate a THz emission over a frequency range of 0 − 2.24 THz, while the THz signal was measured as ∼5 ps. The effect of optical activity was able to rotate the polarization plane on a frequency range of 0 – 1.4 THz for both of the clockwise and the counter-clockwise samples. The maximum polarization plane rotation were +13° and −18° at a frequency 1.35 THz. It can be concluded that the new design planar chiral metamaterial with different depth has been successfully obtained with its elliptic polarized THz emission characteristic.
Student’s Problem Solving Skills in Collaborative Inquiry Learning Supplemented by Formative E-Assessment : Case of Static Fluids
Authors: Siringo Ringo Ernila , Kusairi Sentot , Latifah Eny , Tumanggor Awal M R 
Published: December 2019

Abstract
This research aims to analyze the development of the static fluid problem-solving skills of high school students in collaborative inquiry supplemented by formative e-assessment. This research used a mixed-method approach with the research design of an embedded experimental design model involving 34 students of class XI MIPA in SMA Negeri 4 Malang. The Data on the problem-solving skills were obtained through pretest and posttest using three problem-solving questions in the form of descriptions and supplemented by interviews. The calculation results of N-gain score showed the improvement of student’s problem solving skills for a moderate category and the calculation result of Cohen’s d-effect size in for strong effect category, as many as 79% of the students are categorized as experts. The expert students have good skills in the useful description indicator followed sequentially on the indicator of physics approach, specific application of physics, mathematical procedures, and logical proggression. Meanwhile, the novice students are only capable on the indicator of useful description and physics approach. Students’ skill to solve problems still need to be trained intensively using contectual problems in daily life.