bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase in Population Exposure Due to Dry and Wet Extremes in India Under a Warming Climate
Authors: Kumar Rohini , Mishra Vimal 
Published: November 2020

AbstractDry and wet extremes affect agricultural production, infrastructure, and socioeconomic well‐being of about 1.4 billion people in India. Despite the profound implications of dry and wet extremes, their changes in the observed and projected climate in India are not well quantified. Here, using the observations from multiple sources, we show that the area affected by dry extremes during the monsoon season (June–September) and water‐year (June–May) has significantly increased (~1% per decade; p value < 0.05) over the last six decades (1951–2015) in India. On the other hand, the area affected by wet extremes does not exhibit any significant trend over the same time period. Dry and wet extremes in the monsoon season are corroborated with the positive phase and negative phase of the sea surface temperature (SST) anomalies in the tropical Pacific Ocean (Niño 3.4 region). Global climate models (GCMs) project an increase of more than 25–30% (±3–6%) in the combined area affected by the dry and wet extremes in India by the end of the 21st century. The frequency of both dry and wet extreme years is also projected to increase in the majority of India (>80%) under a warmer world if the global mean temperature rises above 1.5°C (or 2°C) from a preindustrial level. Moreover, the population exposed to the dry and wet extremes is likely to increase threefold under the projected 2°C warmer world. Therefore, limiting global mean temperature rise below 2°C can substantially reduce the area and population exposure due to dry and wet extremes in India.
Projected Changes in Compound Flood Hazard From Riverine and Coastal Floods in Northwestern Europe
Authors: Ganguli Poulomi , Paprotny Dominik , Hasan Mehedi , Güntner Andreas , Merz Bruno 
Published: November 2020

AbstractCompound flooding in coastal regions, that is, the simultaneous or successive occurrence of high sea levels and high river flows, is expected to increase in a warmer world. To date, however, there is no robust evidence on projected changes in compound flooding for northwestern Europe. We combine projected storm surges and river floods with probabilistic, localized relative sea‐level rise (SLR) scenarios to assess the future compound flood hazard over northwestern coastal Europe in the high (RCP8.5) emission scenario. We use high‐resolution, dynamically downscaled regional climate models (RCM) to drive a storm surge model and a hydrological model, and analyze the joint occurrence of high coastal water levels and associated river peaks in a multivariate copula‐based approach. The RCM‐forced multimodel mean reasonably represents the observed spatial pattern of the dependence strength between annual maxima surge and peak river discharge, although substantial discrepancies exist between observed and simulated dependence strength. All models overestimate the dependence strength, possibly due to limitations in model parameterizations. This bias affects compound flood hazard estimates and requires further investigation. While our results suggest decreasing compound flood hazard over the majority of sites by 2050s (2040–2069) compared to the reference period (1985–2005), an increase in projected compound flood hazard is limited to around 34% of the sites. Further, we show the substantial role of SLR, a driver of compound floods, which has frequently been neglected. Our findings highlight the need to be aware of the limitations of the current generation of Earth system models in simulating coastal compound floods.
Data‐Driven Super‐Parameterization Using Deep Learning: Experimentation With Multiscale Lorenz 96 Systems and Transfer Learning
Authors: Chattopadhyay Ashesh , Subel Adam , Hassanzadeh Pedram 
Published: November 2020

AbstractTo make weather and climate models computationally affordable, small‐scale processes are usually represented in terms of the large‐scale, explicitly resolved processes using physics‐based/semi‐empirical parameterization schemes. Another approach, computationally more demanding but often more accurate, is super‐parameterization (SP). SP involves integrating the equations of small‐scale processes on high‐resolution grids embedded within the low‐resolution grid of large‐scale processes. Recently, studies have used machine learning (ML) to develop data‐driven parameterization (DD‐P) schemes. Here, we propose a new approach, data‐driven SP (DD‐SP), in which the equations of the small‐scale processes are integrated data‐drivenly (thus inexpensively) using ML methods such as recurrent neural networks. Employing multiscale Lorenz 96 systems as the testbed, we compare the cost and accuracy (in terms of both short‐term prediction and long‐term statistics) of parameterized low‐resolution (PLR) SP, DD‐P, and DD‐SP models. We show that with the same computational cost, DD‐SP substantially outperforms PLR and is more accurate than DD‐P, particularly when scale separation is lacking. DD‐SP is much cheaper than SP, yet its accuracy is the same in reproducing long‐term statistics (climate prediction) and often comparable in short‐term forecasting (weather prediction). We also investigate generalization: when models trained on data from one system are applied to a more chaotic system, we find that models often do not generalize, particularly when short‐term prediction accuracies are examined. However, we show that transfer learning, which involves re‐training the data‐driven model with a small amount of data from the new system, significantly improves generalization. Potential applications of DD‐SP and transfer learning in climate/weather modeling are discussed.
Petrochronology of Wadi Tayin Metamorphic Sole Metasediment, With Implications for the Thermal and Tectonic Evolution of the Samail Ophiolite (Oman/UAE)
Authors: Garber Joshua M. , Rioux Matthew , Kylander‐Clark Andrew R. C. , Hacker Bradley R. , Vervoort Jeffrey D. , Searle Michael P. 
Published: November 2020

AbstractOphiolite metamorphic soles preserve important records of ophiolite emplacement, but there have been few detailed investigations into their non‐mafic portions. We present new thermobarometric and petrochronologic data from a metasediment and mafic restite in the upper Wadi Tayin sole exposure in the Samail (Oman‐UAE) Ophiolite. Thermodynamic modeling suggests metasedimentary garnet nucleation at ~4 kb, ~550°C and final growth at 7.5 ± 1.2 kbar, 665 ± 32°C, occurring by 93.0 ± 0.5 Ma (Lu‐Hf isochron). Zircon U‐Pb dates of 106.9 ± 2.3 (detrital) and 98.7 ± 1.7 to 94.1 ± 1.6 Ma (metamorphic) bracket the initiation of metamorphism, and monazite U‐Pb dates from ~97–89 Ma suggest a lengthy period of growth or recrystallization. A mafic titanite U‐Pb age of 92.2 ± 1.8 Ma records the earliest possible juxtaposition of high‐ and lower‐grade sole rocks. These and other data suggest that (i) the Wadi Tayin sole preserves an inverted metamorphic, metasomatic, and age gradient,(ii) metasediment metamorphism occurred during, or soon after, crystallization of the overlying ophiolite (≤96.5 Ma); and (iii) sole metasediments define a thermal gradient continuous with hotter, higher‐P amphibolites. Some of these data conflict with existing models for sole formation, and we propose several hypotheses to explain them. Cooling of the sole below Ar closure by ~92 Ma suggests that strain rapidly partitioned away from the sole, leading to large‐scale, thin‐skinned thrust emplacement of the ophiolite >100 km across the continental margin and the late, cool underthrusting of the continental margin.
Comparison of Groundwater Storage Changes From GRACE Satellites With Monitoring and Modeling of Major U.S. Aquifers
Authors: Rateb Ashraf , Scanlon Bridget R. , Pool Donald R. , Sun Alexander , Zhang Zizhan , Chen Jianli , Clark Brian , Faunt Claudia C. , Haugh Connor J. , Hill Mary , Hobza Christopher , McGuire Virginia L. , Reitz Meredith , Müller Schmied Hannes , Sutanudjaja Edwin H. , Swenson Sean , Wiese David , Xia Youlong , Zell Wesley 
Published: November 2020

AbstractGRACE satellite data are widely used to estimate groundwater storage (GWS) changes in aquifers globally; however, comparisons with GW monitoring and modeling data are limited. Here we compared GWS changes from GRACE over 15 yr (2002–2017) in 14 major U.S. aquifers with groundwater‐level (GWL) monitoring data in ~23,000 wells and with regional and global hydrologic and land surface models. Results show declining GWS trends from GRACE data in the six southwestern and south‐central U.S. aquifers, totaling −90 km3 over 15 yr, related to long‐term (5–15 yr) droughts, and exceeding Lake Mead volume by ~2.5×. GWS trends in most remaining aquifers were stable or slightly rising. GRACE‐derived GWS changes agree with GWL monitoring data in most aquifers (correlation coefficients, R = 0.52–0.95), showing that GRACE satellites capture groundwater (GW) dynamics. Regional GW models (eight models) generally show similar or greater GWS trends than those from GRACE. Large discrepancies in the Mississippi Embayment aquifer, with modeled GWS decline approximately four times that of GRACE, may reflect uncertainties in model storage parameters, stream capture, pumpage, and/or recharge rates. Global hydrologic models (2003–2014), which include GW pumping, generally overestimate GRACE GWS depletion (total: approximately −172 to −186 km3) in heavily exploited aquifers in southwestern and south‐central U.S. by ~2.4× (GRACE: −74 km3), underscoring needed modeling improvements relative to anthropogenic impacts. Global land surface models tend to track GRACE GWS dynamics better than global hydrologic models. Intercomparing remote sensing, monitoring, and modeling data underscores the importance of considering all data sources to constrain GWS uncertainties.
Climate and Landscape Controls of Regional Patterns of Flow Duration Curves Across the Continental United States: Statistical Approach
Authors: Ghotbi Saba , Wang Dingbao , Singh Arvind , Mayo Talea , Sivapalan Murugesu 
Published: November 2020

AbstractThe flow duration curve (FDC) is a hydrologically meaningful representation of the statistical distribution of daily streamflows. The complexity of processes contributing to the FDC introduces challenges for the direct exploration of physical controls on FDC. In this paper, the controls of climate and catchment characteristics on FDC are explored using a stochastic framework that enables construction of the FDC from three components of streamflow: fast and slow flow (during wet days) and slow flow during dry days. The FDC during wet days (FDCw) is computed as the statistical sum of the fast flow duration curve (FFDC) and the slow flow duration curve (SFDCw), considering their dependency. FDC is modeled as the mixture distribution of FDCw and the slow flow duration curve during dry days (SFDCd), by considering the fraction of wet days (δ) for perennial streams and both δ and the fraction of days of zero streamflow for ephemeral streams. The Kappa distribution is employed to fit the FFDC, SFDCw, and SFDCd for 300 catchments from Model Parameter Estimation Experiment (MOPEX) across the United States. Results show that the 0–20th percentile of FDC is controlled by FFDC and SFDCw, the 90–100th percentile of FDC is controlled by SFDCd, and the 20–90th percentile of FDC is controlled by three components. The relationships between estimated Kappa distribution parameters and climate and catchment characteristics reveal that the aridity index, the coefficient of variation of daily precipitation, timing of precipitation, time interval between storms, snow, topographic slope, and slope of recession slope curve are dominant controlling factors.
Zinner syndrome and infertility─a literature review based on a clinical case
Authors: Hofmann Aybike , Vauth Franziska , Roesch Wolfgang H. 
Published: November 2020

AbstractZinner syndrome (ZS) is a rare congenital malformation associated with seminal vesicle cysts, ejaculatory duct obstruction, and ipsilateral renal agenesis. The main treatment focus so far has been on symptomatic patients. Therefore, surgery has been reserved for these patients, and surgical treatment is mainly aimed at pain relief. ZS seems to be frequently associated with infertility, but diagnosing is challenging, particularly during adolescence. This literature review of ZS and infertility is based on the medical report of one adolescent patient.
Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars
Authors: Patel Zarana S. , Brunstetter Tyson J. , Tarver William J. , Whitmire Alexandra M. , Zwart Sara R. , Smith Scott M. , Huff Janice L. 
Published: November 2020

AbstractNASA’s plans for space exploration include a return to the Moon to stay—boots back on the lunar surface with an orbital outpost. This station will be a launch point for voyages to destinations further away in our solar system, including journeys to the red planet Mars. To ensure success of these missions, health and performance risks associated with the unique hazards of spaceflight must be adequately controlled. These hazards—space radiation, altered gravity fields, isolation and confinement, closed environments, and distance from Earth—are linked with over 30 human health risks as documented by NASA’s Human Research Program. The programmatic goal is to develop the tools and technologies to adequately mitigate, control, or accept these risks. The risks ranked as “red” have the highest priority based on both the likelihood of occurrence and the severity of their impact on human health, performance in mission, and long-term quality of life. These include: (1) space radiation health effects of cancer, cardiovascular disease, and cognitive decrements (2) Spaceflight-Associated Neuro-ocular Syndrome (3) behavioral health and performance decrements, and (4) inadequate food and nutrition. Evaluation of the hazards and risks in terms of the space exposome—the total sum of spaceflight and lifetime exposures and how they relate to genetics and determine the whole-body outcome—will provide a comprehensive picture of risk profiles for individual astronauts. In this review, we provide a primer on these “red” risks for the research community. The aim is to inform the development of studies and projects with high potential for generating both new knowledge and technologies to assist with mitigating multisystem risks to crew health during exploratory missions.
Loss of sympathetic innervation to islets of Langerhans in canine diabetes and pancreatitis is not associated with insulitis
Authors: Gilor Chen , Pires Jully , Greathouse Rachel , Horn Rebecca , Huising Mark O. , Marks Stanley L. , Murphy Brian , Kol Amir 
Published: November 2020

AbstractCanine diabetes mellitus (DM) affects 0.6% of the canine population and yet, its etiology is poorly understood. Most affected dogs are diagnosed as adults and are insulin-dependent. We compared pan-leukocyte and sympathetic innervation markers in pancreatic islets of adult dogs with spontaneous DM (sDM), spontaneous pancreatitis (sPanc), both (sDMPanc), toxin-induced DM (iDM) and controls. We found evidence of decreased islet sympathetic innervation but no significant infiltration of islets with leukocytes in all disease groups. We show that loss of sympathetic innervation is ongoing in canine DM and does not necessarily precede it. We further found selective loss of islet-associated beta cells in dogs with sDM and sDMPanc, suggesting that collateral damage from inflammation in the exocrine pancreas is not a likely cause of DM in these dogs. The cause of this selective loss of beta cells needs to be further elucidated but overall, our findings are not supportive of an autoimmune process as a cause of sDM in adult dogs. The loss of sympathetic innervation in sPanc in dogs that do not suffer from DM links the disease in the exocrine pancreas to a pathological process in the endocrine pancreas, suggesting pancreatitis might be a potential precursor to DM.
The influence of early life socialisation on cognition in the domestic pig (Sus scrofa domestica)
Authors: Weller Jennifer E. , Turner Simon P. , Futro Agnieszka , Donbavand Jo , Brims Mark , Arnott Gareth 
Published: November 2020

AbstractPreviously, the benefits of early-life socialisation on later-life social development have been reported in pigs. Here we investigated the effect of pre-weaning socialisation on the later-life cognitive ability of pigs using a range of techniques. Pre-weaning, 101 piglets had access to a neighbouring pen from ~ 15 days of age and interacted with non-littermates (socialised). An additional 89 piglets remained isolated within their home pen (controls). After weaning, 100 individuals were selected for a range of cognitive tests including a food reward T-maze test, reversal learning T-maze test, a social preference T-maze test, and a puzzle box test. Performance during the food reward test was not influenced by treatment. Treatment effected improvement over the course of the reversal learning test, with controls showing a significant decrease in trial duration after the first two trials. During the social preference test, socialised pigs spent significantly more time in the presence of larger stimulus pigs than controls and were quicker to leave the middle of the maze, suggesting improved social skills. Neither sex nor treatment was observed to influence pig’s ability to solve the puzzle box. Thus, overall, evidence from the social preference test suggests an effect of pre-weaning socialisation on aspects of social cognitive development.
Analysis of transcriptional modules during human fibroblast ageing
Authors: Lee Yaelim , Shivashankar G. V. 
Published: November 2020

AbstractFor systematic identification of transcription signatures of human cell aging, we carried out Weighted Gene Co-expression Network Analysis (WGCNA) with the RNA-sequencing data generated with young to old human dermal fibroblasts. By relating the modules to the donor's traits, we uncovered the natural aging- and premature aging disease-associated modules. The STRING functional association networks built with the core module memberships provided a systematic overview of genome-wide transcriptional changes upon aging. We validated the selected candidates via quantitative reverse transcription PCR (RT-qPCR) assay with young and aged human fibroblasts, and uncovered several genes involved in ECM, cell, and nuclear mechanics as a potential aging biomarker. Collectively, our study not only provides a snapshot of functional changes during human fibroblast aging but also presents potential aging markers that are relevant to cell mechanics.
Globe rupture: a single-center retrospective study of demographic patterns and outcomes
Authors: Choovuthayakorn Janejit , Chokesuwattanaskul Susama , Upaphong Phit , Supreeyathitikul Pongsant 
Published: November 2020

AbstractGlobe rupture is one of the severe mechanisms of eye injury. This study aimed to describe an epidemiologic patterns and visual outcomes of the open globe injury from globe rupture at a tertiary referral centre. Medical records of 167 patients (173 eyes) were retrospectively reviewed. Overall, males were predominant (82%). Road traffic- (26.3%) and work- (23.4%) were the major contributors. However, falling was the main mechanism in the elderly aged over 60 years. At presentation, 91.4% of eyes had initial visual acuity (VA) of worse than 20/200. The mean (SD) VA in logarithm of the minimum angle of resolution (LogMAR) unit at final [1.8 (1.1)] was significantly improved from presenting VA [2.4 (0.6)] (p ˂ 0.001). Predictors for final VA of worse than 20/400 included poor initial VA, presence of relative afferent pupillary defect, and endophthalmitis. In conclusion, this study observed the peak incidence of globe rupture in young teen to early adult patients, with unique characteristics in each age group. Even with significant visual improvement following the treatments, profound visual loss was still a common consequence. Thus, the role of effective prevention along with a multidisciplinary team together with timely and prompt ophthalmic management should be emphasised.
Evaluation of coagulation parameters in patients with parathyroid adenoma
Authors: Alay Murat , Ercek Berrak Mermit , Sonmez Gulcin Miyase , Sakin Aysegul , Ucler Rifki , Yildiz Saliha 
Published: November 2020

AbstractParathyroid adenoma is responsible for 80–85% of cases of primary hyperparathyroidism. Increased fibrinogen levels in patients with adenoma may increase the risk of atherosclerosis and cardiovascular events. The aim of this study was to investigate the relationship between coagulation parameters and parathyroid adenoma. A prospective study included 28 female patients with parathyroid adenoma aged 40–88 years and 27 age-matched healthy controls. The coagulation parameters were assessed for each participant. The mean ages of the patient and control groups were 57.7 ± 10.9 and 53.3 ± 9.31 years, respectively. The mean level of protein S activity was 65.79 ± 13.78 in the patient group and 77.00 ± 15.72 in the control group, and the difference was statistically significant (p = 0.013). The mean fibrinogen levels of the patient and control groups were 338.78 ± 63.87 mg/dL and 304.30 ± 45.67 mg/dL, respectively, and a significant difference was found (p = 0.041). However, no significant difference was evident between the two groups with regard to the D-dimer (p = 0.238), aPTT (p = 0.645), INR (p = 0.406), protein C (p = 0.076), and AT-III (p = 0.180) levels. A positive correlation was observed between adenoma volume and fibrinogen in the patient group (r = 0.711, p = 0.001). The protein S levels were lower and the fibrinogen levels higher in the patients with parathyroid adenoma.
Impact of sound levels and patient-related factors on sleep of patients in the intensive care unit: a cross-sectional cohort study
Authors: Czempik Piotr F. , Jarosińska Agnieszka , Machlowska Krystyna , Pluta Michał P. 
Published: November 2020

AbstractSleep disruption is common in patients in the intensive care unit (ICU). The aim of the study was to measure sound levels during sleep-protected time in the ICU, determine sources of sound, assess the impact of sound levels and patient-related factors on duration and quality of patients' sleep. The study was performed between 2018 and 2019. A commercially available smartphone application was used to measure ambient sound levels. Sleep duration was measured using the Patient's Sleep Behaviour Observational Tool. Sleep quality was assessed using the Richards-Campbell Sleep Questionnaire (RCSQ). The study population comprised 18 (58%) men and 13 (42%) women. There were numerous sources of sound. The median duration of sleep was 5 (IQR 3.5–5.7) hours. The median score on the RCSQ was 49 (IQR 28–71) out of 100 points. Sound levels were negatively correlated with sleep duration. The cut-off peak sound level, above which sleep duration was shorter than mean sleep duration in the cohort, was 57.9 dB. Simple smartphone applications can be useful to estimate sound levels in the ICU. There are numerous sources of sound in the ICU. Individual units should identify and eliminate their own sources of sound. Sources of sound producing peak sound levels above 57.9 dB may lead to shorter sleep and should be eliminated from the ICU environment. The sound levels had no effect on sleep quality.