bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of local consolidative therapy in Osimertinib-treated non-small cell lung cancer with oligo-residual disease
Authors: Zeng Ya , Ni JianJiao , Yu Fan , Zhou Yue , Zhao Yang , Li Shuyan , Guo Tiantian , Chu Li , Yang Xi , Chu Xiao , Cai XuWei , ZHU Zhengfei 
Published: August 2020

Abstract
Background: There was no study investigating real-world utilization and outcome of LCT in Osimertinib-treated NSCLC with oligo-residual disease. This study was to analyze the clinical value of local consolidative therapy (LCT) in Osimertinib-treated non-small cell lung cancer (NSCLC) patients with oligo-residual disease. Methods: Patients receiving standard Osimertinib treatment and developing oligo-residual disease (ﬁve or fewer residual metastatic lesions) were retrospectively reviewed. Local therapies performed to the oligo-residual tumor lesions or primary lung site before Osimertinib treatment failure were considered as LCT. Results: Of 108 patients recruited, first-line and second-line Osimertinib were administered in 25 and 83 patients, respectively, while LCT was performed in 14 patients. With a median follow-up of 43.6 months, 69 patients developed progressive disease. LCT significantly improved progression-free survival (PFS) (NR vs 12.8 months, p=0.01) and was independently associated with prolonged PFS (HR=0.29, 95%CI 0.12 to 0.68, p=0.004). Patients receiving LCT had a numerically longer overall survival (OS) (85.8 vs 77.1 months, p=0.58) and after adjusting for potentially confounding factors, LCT was associated with a non-significantly prolonged OS (HR=0.37, 95%CI 0.12-1.16, p=0.089). Pattern of failure analyses indicated that progressive disease developed at the originally existed oligo-residual lesions in 76.2% of the 63 patients who didn’t receive LCT and had Osimertinib treatment failure. Of note, 7 (70%) of the 10 patients who had oligo-residual cranial disease but didn’t receive LCT, developed more than five progressive lesions in the brain, which were no longer suitable for stereotactic radiosurgery. Conclusion: Among Osimertinib-treated NSCLC patients having oligo-residual lesions, LCT could improve local control and significantly increase PFS, which need to be verified by further investigations.
Type 2 diabetes and COPD: treatment in the right healthcare setting? An observational study.
Authors: Willink Rimke P , Vos Rimke C , Akker Ingrid Looijmans-van den , Hart Huberta E 
Published: August 2020

Abstract
Background Type 2 diabetes (T2DM) and COPD are chronic conditions, for which patients need lifelong healthcare. The aim of the study is to examine in which healthcare setting patients with T2DM and COPD receive care, and if they are allocated to the correct setting.Method T2DM and COPD patients from five primary care centres were included. Data concerning treatment setting, patient- and clinical characteristics were extracted from electronic medical records. The profile of patients treated in primary care was compared with that of those treated in secondary care. For patients treated in secondary care we evaluated whether treatment allocation was according to guidelines and if back-referral to primary care could take place.Results Of the T2DM and COPD patients 7.6% and 29.6% were treated in secondary care of which 72.7% and 31.4% according to the guideline. T2DM patients treated in primary care were older (63 versus 57 years, p = 0.001), had a shorter diabetes duration (8 versus 11 years, p < 0.001) and lower HbA1c (53.0 versus 63.5 mmmol/l, p < 0.001) than those treated in secondary care. Those with COPD treated in primary care used less inhalation medication (75.2 versus 90.1%, p < 0.001) and had better spirometry results (67.39 versus 57.53 FEV1%pred, p < 0.001).Conclusion The majority of the patients with T2DM and COPD were treated in primary care correctly. Patients treated in primary care on average had a better health condition compared to those in secondary care. The majority of the T2DM patients and the minority of COPD patients were treated correctly in secondary care.
Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
Authors: Butti Zoe , Giacomotto Jean , Patten Kessen (Shunmoogum) 
Published: August 2020

Abstract
A hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD). Reduced levels of C9orf72 mRNA and protein have been found in ALS/FTD patients, but the role of this protein in disease pathogenesis is still poorly understood. Here, we report the generation and characterization of a stable C9orf72 loss-of-function (LOF) model in the zebrafish. We show that reduced C9orf72 function leads to motor defects, muscle atrophy, motor neuron loss and mortality in early larval and adult stages. Analysis of the structure and function of the neuromuscular junctions (NMJs) of the larvae, reveal a significant reduction in the number of presynaptic and postsynaptic structures and an impaired release of quantal synaptic vesicles at the NMJ. Strikingly, we demonstrate a downregulation of SV2a upon C9orf72-LOF and a reduced rate of synaptic vesicle cycling. Furthermore, we show a reduced number and size of Rab3a-postive synaptic puncta at NMJs. Altogether, these results reveal a key function for C9orf72 in the control of presynaptic vesicle trafficking and release at the zebrafish larval NMJ. Our study demonstrates a novel role for C9orf72 in ALS/FTD pathogenesis, where it regulates synaptic vesicle release and neuromuscular functions.
Efficient biogenesis of Au nanoparticles using extract of Mentha pulegium flower: Evaluation of catalytic reduction of nitroarenes and anti-human colon cancer properties in the in vitro condition
Authors: Bovandi Shabnam , Shahriari Maryam , Zangeneh Mohammad Mahdi 
Published: August 2020

Abstract
Background

With regards to applicative, facile, green chemical research, a bio-inspired approach is being reported for the synthesis of Au nanoparticles by using Mentha pulegium flower extract.
Methods

The phytochemical immobilized Au NPs were characterized by advanced physicochemical techniques like Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), and X-ray Diffraction (XRD) study. Thereafter, catalytic performance of those biomolecule functionalized Au NPs was investigated in the efficient reduction of nitroarenes over a range of substrates. To survey the anti-human colon cancer effects of gold nanoparticles, MTT assay was used on the common colon cancer cell lines i.e., colorectal adenocarcinoma (HT-29), colorectal carcinoma (HCT 116), ileocecal colorectal adenocarcinoma (HCT-8 [HRT-18]), and Burkitt's lymphoma (Ramos.2G6.4C10).
Results

The conversion was achieved in short reaction time with good to excellent yields in association with outstanding turnover frequency (TOF). In addition, the nanocomposite catalyst was easily recovered and recycled for 12 successive times without noticeable decrease in catalytic activity. Gold nanoparticles had high anti-colon cancer activities dose-dependently against HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10 cell lines. The best result of anti-colon cancer effects was seen in the case of the HCT 116 cell line.
Conclusions

It looks gold nanoparticles can be used for the treatment of several types of colon cancers in human.
Quantitative DCE-MRI: An Efficient Diagnostic Technique for Evaluating Early Micro-environment Permeability Changes in Ankylosing Spondylitis
Authors: Yang Hui , Jiang Ling , Li Jiang , Zheng Xiuzhu , Yao Qianqian , Li Changqin , Zhu Jianzhong , Qin Jian 
Published: August 2020

Abstract
Background: In the management of early inflammatory joint of ankylosing spondylitis (AS), there is a need for reliable noninvasive quantitative methods to closely monitor synovial inflammation to predict early diagnosis.Cognizant to this,studies geared on improving techniques for quantitative evaluation of micro-environment permeability of the joint space are necessary.Such improved techniques may provide tissue perfusion as important biological parameters and can further help in understanding the origin of early changes associated with AS.Aims:To prospectively evaluate the diagnostic performance and determine longitudinal relationships of early micro-environment active in the joint space of the sacroiliac joint (SIJ) with a rat model by using quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).Methods: Thirty wistar male rats were randomly assigned to the model (n= 15) or control (n = 15) group. All rats underwent DCE-MRI of SIJ region at fixed time points(12, 17 and 22 weeks),between September 2018 and October 2019. Differences in permeability parameters between the two groups at the same time point were compared by using an independent samples t test.Spearman correlations of DCE-MRI parameters with different time points in model group were analyzed.All statistical analyses were performed with software.Results: At 12 weeks,the Ktrans,Kep and Ve values in the model group were slightly lower than those in control group,but all the differences were not statistically significant (p>0.05).Compared with control group,the transfer constant (Ktrans)values increased significantly at 17 weeks and 22 weeks in model group,while the rate constant (Kep) and volume of extravascular extracellular space(Ve) significantly increased only at 22weeks(p<0.05).The Ktrans,Kep and Ve were positively correlated with increasing time points (r=0.94, P＜0.01 for Ktrans; r=0.93, P＜0.01 for Kep; and r= 0.89, P＜0.01 for Ve).Conclusions: Quantitative DCE-MRI parameters are valuable for evaluating the early longitudinal relationship of micro-environment permeability changes in the joint space of SIJ.
Liquid-crystalline chiral phase formation and structural transitions of dumbbell-shaped colloids
Authors: Yang Yang , Chen Guangdong , Pei Hanwen , Zhang Xuefei , Shi Wei , Liu Mingjie , Faul Charl , Yang Bai , Lu Zhongyuan , Liu Kun , Nie Zhihong 
Published: August 2020

Abstract
Colloidal liquid crystals (LCs) are an emerging class of soft materials that naturally combine the unique properties of both LC molecules and colloidal particles. Chiral LC blue phases are highly attractive in fast optical displays and electrooptical devices, but the formation of chiral structures from achiral colloidal particles is rare. Herein we demonstrate that achiral dumbbell-shaped colloids can assemble into a rich variety of characteristic LC phases, including nematic phases with lock structures, smectic phases, and particularly double-twisted chiral columnar phases. Phase diagrams from experiments and simulations show that the existence and stable regions of different LC phases are strongly dependent on the geometry of colloids. Furthermore, the LC phases can be dynamically tuned by external magnetic fields. This work paves a new route to the development of stimuli-responsive functional LC mesostructures for LC display and laser applications.
Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.
Authors: Malawsky Daniel Shiloh , Weir Seth , Ocasio Jennifer , Babcock Ben , Dismuke Taylor , Wilhelmsen Kirk , Gershon Timothy (R.) 
Published: August 2020

Abstract
Patients with medulloblastoma are typically treated with a narrow range of therapies, but may experience widely divergent outcomes; 80-90% become long-term survivors while 20% develop incurable recurrence. Transcriptomic profiling has identified four subgroups with different recurrence risks, but outcomes remain variable for individual patients within each subgroup. To gain new insight into why patients with similar-appearing tumors have variable outcomes, we examined how the timing of tumor initiation effects medulloblastomas triggered by a single, common driver mutation. We genetically-engineered mice to express an oncogenic Smo allele starting early in development in the broad lineage of neural stem cells, or later, in the more committed lineage of cerebellar granule neuron progenitors. Both groups developed medulloblastomas and no other tumors. We compared medulloblastoma progression, response to therapy, gene expression profile and cellular heterogeneity, determined by single cell transcriptomic analysis (scRNA-seq). The average transcriptomic profiles of the tumors were similar. However, stem cell-triggered medulloblastomas progressed faster, contained more OLIG2-expressing tumor stem cells, and consistently showed radioresistance. In contrast, progenitor-triggered MBs progressed slower, lost stem cell character over time and were radiosensitive. Progenitor-triggered medulloblastomas also contained more diverse stromal populations, including tumor-associated macrophages, indicating that the timing of oncogenesis affected the subsequent interactions between the tumor and microenvironment. Our findings show that developmental events in tumorigenesis may be impossible to infer from transcriptomic profile, but while remaining cryptic can nevertheless influence tumor composition and the outcome of therapy. Precise understanding of medulloblastoma pathogenesis and prognosis requires supplementing transcriptomic data with biomarkers of cellular heterogeneity.
Utility of Oxygen Insufflation Through Working Channel During Fiberoptic Intubation: a Prospective Randomized Controlled Study
Authors: Roh Go Un , Kang Joon Gwon , Han Jung Youn , Chang Chul Ho 
Published: August 2020

Abstract
Background: Airway management is a part of routine anesthetic procedures; however, serious complications, including hypoxia and death, are known to occur in cases of difficult airways. Therefore, alternative techniques such as fiberoptic bronchoscope-assisted intubation (FOBI) should be considered, although this method requires more time and offers a limited visual field than does intubation with a direct laryngoscope. Oxygen insufflation through the working channel during FOBI could minimize the risk of desaturation and improve the visual field. Therefore, the aim of this prospective randomized controlled study was to evaluate the utility and safety of oxygen insufflation through the working channel during FOBI. Methods: Thirty-six patients were randomly allocated to an N group (no oxygen insufflation) or an O group (oxygen insufflation). After preoxygenation, FOBI was performed with (O group) or without (N group) oxygen insufflation. The primary outcome was the velocity of decrease in the partial pressure of oxygen during FOBI (VPaO2), while secondary outcomes included the success rate for FOBI, time to intubation, visual field during FOBI, findings of arterial blood gas analysis, and occurrence of FOBI-related complications. Results: We found that VPaO2 was significantly greater in the N group than in the O group (1.01 ± 0.39 vs. 0.42 ± 0.42; p < 0.001), while the visual field was similar between groups. There were no significant intergroup differences in the secondary outcomes. Conclusions: These findings suggest that oxygen insufflation through the working channel during FOBI aids in extending the apneic window during the procedure.Trial registration: ClinicalTrials.gov, NCT02625194, registered at December 9, 2015
Social Emotional Development in the Chinese Children with Cerebral Palsy Aged at 1 to 3 Years and the Associated Risk Factors: A Cross-sectional Study
Authors: Wu You , Tang Jianyong , Chen Yanni , Huang Yanxia 
Published: August 2020

Abstract
Background: With cerebral palsy children's psychological behavior problems loom large, it gradually be taken seriously. This research aimed to analyze the social emotional disorders of the Chinese children with cerebral palsy aged at 1~3 years, and further screen out the independent risk factors that affect their social emotional development.Methods: A total of 300 Chinese children with cerebral palsy aged 1~3 years-old(192 males, 108 females) and their parents took part in this cross-sectional survey, in which the Chinese Version of Infant Toddler Social-Emotional Assessment (CITSEA), the Bayley Scales of Infant Development (BSID) and the Gross Motor Function Measure (GMFM-88) were for children while the Coping Style Questionnaire, the Hospital Anxiety and Depression Scale ( HADS) were for parents. The independent risk factors related to social emotional disorders were screened out using a multivariate logistic or linear regression analysis.Results: The scores of the externalizing and competency domains for the children with cerebral palsy in different age groups were lower than those for healthy children of the same age and gender (p<0.05). For the boys with cerebral palsy, aged at 12~17 and 18~23 months, the scores of the internalizing and dysregulation domains were significantly lower than the norm (p<0.01). The effect of perinatal factors on the externalizing and competency domains is more significant than that on other domains, while the coping style of the parents significantly affected the positive detection rate of dysregulation domain (p=0.001). Conclusions: This study found that the parental emotional state, the education level, the parenting style and the perinatal factors are closely related to social emotional problems in the Chinese children with cerebral palsy.
Triphenylphosphine-catalyzed Alkylative Iododecarboxylation with Lithium Iodide under Visible Light
Authors: Fu Min-Chen , Wang Jia-Xin , Shang Rui 
Published: August 2020

Abstract
Photoactivation of an electron donor–acceptor encounter complex in an organic solvent cage, a phenomenon that has been described in Mulliken theory, has been known for decades, but it has not been employed as a photoactivation step in the design of photocatalysis for organic synthesis until recent years. We report herein an iododecarboxylation reaction that applies this concept for photoactivation by using a catalyst to facilitate electron transfer and to suppress back electron transfer in the photoexcited state. Under irradiation of 456 nm blue light-emitting diodes, PPh3 catalyzes the iododecarboxylation of aliphatic carboxylic acid-derived N-(acyloxy)phthalimide with lithium iodide as iodine source. The reaction delivers primary, secondary, and bridgehead tertiary alkyl iodides in acetone solvent, and the alkyl iodide products were easily used to generate C–N, C–O, C–F, and C–S bonds to allow various decarboxylative transformations without using transition-metal or organic dye-based photocatalysts. This protocol is applicable to redox-active esters derived from various natural products and pharmaceuticals.
Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study
Authors: Cui Ming , Liu Jing-Kai , Zheng Bang , Liu Qiao-Fei , Zhang Lu , Zhang Li , Guo Jun-Chao , Dai Meng-Hua , Zhang Tai-Ping , Liao Quan 
Published: August 2020

Abstract
Background: The clinical outcomes of distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) patients have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. Methods: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effect model was used to compare dynamic hematological changes between different groups. Results: In total, 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups. Conclusions: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.
Circulating and Local Nuclear Expression of Survivin and Fibulin-3 Genes in Discriminating Benign From Malignant Respiratory Diseases: Correlation Analysis
Authors: Hassan Mohammed H. , Abuhamdah Sawsan , Abdel-Bary Mohamed , Wahman Mohammed , Abd-Elhamid Tarek Hamdy , Beshay Morris , Mosallam Karam , Elsadek Bakheet E.M. 
Published: August 2020

Abstract
Background: Survivin is a common member of the inhibitors of the apoptosis protein (IAP) family and promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein with a potential for tumor suppression or propagation. The aim of this study was to validate the expression levels of survivin and fibulin-3 in benign and malignant respiratory diseases.Methods: This case-control study included 219 patients categorized into 5 groups. Group A included 63 patients with lung cancer, group B included 63 patients with various benign lung diseases, group D included 45 patients with malignant pleural mesothelioma (MPM) and group E included 48 patients with various benign pleural diseases. Group C included 60 healthy individuals (control group). Serum survivin and fibulin-3 levels were measured using ELISA assay kits, while their nuclear expression in the lung and pleura was assessed using western blot analysis. Data entry and data analysis are done using SPSS version 19. The Medcalc Program was used to calculate sensitivity, specificity and positive and negative predictive values with calculation of the AUC (95% CI). Results: The overall results showed significantly higher survivin serum levels with significantly lower fibulin-3 levels among group A when compared with both patients in group B and the controls (p<0.001 for all). There were statistically significant higher serum levels of survivin and fibulin-3 among group D when compared with both patients in group E and the controls (p<0.001 for all). These findings were consistent with nuclear survivin and fibulin-3 expression levels. Fibulin-3 was more valid than survivin in discriminating lung cancer from MPM (p˂0.05). Conclusions: Survivin and fibulin-3 could be helpful diagnostic markers for lung and pleural cancers. Fibulin-3 was more specific in differentiating lung cancer from MPM.Trial registration: ClinicalTrials.gov Identifier: NCT04413292: https://clinicaltrials.gov/ct2/show/NCT04413292, retrospectively registered.
Drought Assessment of Eastern Satara District of Maharashtra Using Rainfall Anomaly Index
Authors: Waghmare Prakash T , Panhalkar Sachin S , Pawar Somanath D 
Published: August 2020

Abstract
Drought is universally acknowledged as a phenomenon associated with scarcity of water. Proper assessment of rainfall is an essential need to reduce the intensity of drought. Present work aims study the space-time variation in the rainfall of the eastern part of the Satara district of Maharashtra using the Rainfall Anomaly Index (RAI). Daily precipitation data of sixteen meteorological stations were used for the period between 1979 and 2013. RAI was calculated and plotted in spatial distribution maps. The overall investigation reveals that the eastern and southern part of the study area is prone to dry condition. The present investigation is useful to delineate potential sites of drought and through this study risk of future drought conditions can be curtailed.