bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual regulation of Li+ migration of Li6.4La3Zr1.4M0.6O12 (M = Sb, Ta, Nb) by bottleneck size and bond length of M−O
Authors: Xiang Xing , Chen Fei , Yang Wenyun , Yang Jinbo , Ma Xiaobai , Chen Dongfeng , Su Kai , Shen Qiang , Zhang Lianmeng 
Published: November 2019

AbstractBottleneck size is the minimum Li+ migration channel of Li7La3Zr2O12 (LLZO) and it greatly influences the Li+ conductivity. Doping different elements on the Zr site of LLZO can adjust the bottleneck size and improve the Li+ conductivity. However, the regulation mechanism is not clear. In this work, Li6.4La3Zr1.4M0.6O12 (M = Sb, Ta, Nb) has been prepared and the bottleneck size has been adjusted by doping different pentavalent ions. The results manifest that the cell parameter and bottleneck size decrease with the rise of the radius of doped pentavalent ions. This is because larger pentavalent ion leads to larger bond length of M–O, and weaker covalent component between M5+ and O2‐, corresponding, the formal charge on the M5+ become larger, and the bond length of La–O slightly decreases due to the coulomb repulsion between La3+ and M5+ increase. While, the activation energy drop firstly and then rise with the rise of bottleneck size because of the migration of Li+ not only relate to the size of the migration channel but also to the strength of M–O covalent bonding. The bottleneck size and bond length of M–O synergistically affect the migration of Li+.
Systematic screening identifies a 2‐gene signature as a high‐potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma
Authors: Hu Qinsheng , Zhou Shijie , Hu Xuefeng , Zhang Hua , Huang Shishu , Wang Yunbing 
Published: November 2019

AbstractThe Cancer Genome Atlas (TCGA) Research Network confirmed that undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) share a high level of genomic similarities and fall into a single spectrum of tumour. However, no molecular prognostic biomarkers have been identified in UPS/MFS. In this study, by extracting data from TCGA‐Sarcoma (SARC), we explored relapse‐related genes, their prognostic value and possible mechanisms of the dysregulations. After systematic screening, ITGA10 and PPP2R2B were included to construct a 2‐gene signature. The 2‐gene signature had an AUC value of 0.83 and had an independent prognostic value in relapse‐free survival (RFS) (HR: 2.966, 95%CI: 1.995‐4.410 P < .001), and disease‐specific survival (DSS) (HR: 2.283, 95%CI: 1.358‐3.835, P = .002), as a continuous variable. Gene‐level copy number alterations (CNAs) were irrelevant to their dysregulation. Two CpG sites (cg15585341 and cg04126335) around the promoter of ITGA10 showed strong negative correlations with ITGA10 expression (Pearson's r < −0.6). Transcript preference was observed in PPP2R2B expression. The methylation of some CpG sites in two gene body regions showed at least moderate positive correlations (Pearson's r > .4) with PPP2R2B expression. Besides, the 2‐gene signature showed a moderate negative correlation with CD4 + T cell infiltration. High‐level CD4 + T cell infiltration and neutrophil infiltration were associated with significantly better RFS. Based on these findings, we infer that the 2‐gene signature might be a potential prognostic marker in patients with UPS/MFS. Considering the potential benefits of immunotherapy for UPS/MFS patients, it is imperative to explore the predictive value of this signature in immunotherapeutic responses in the future.
Nominal GDP Targeting with Heterogeneous Labor Supply
Authors: BULLARD JAMES , SINGH AARTI 
Published: November 2019

AbstractWe study nominal gross domestic product (GDP) targeting as optimal monetary policy in a model with a credit market friction following Azariadis et al. (2018), henceforth ABSS. We extend the ABSS framework to allow for heterogeneous labor supply. We show that nominal GDP targeting continues to characterize optimal monetary policy in this setting. We also analyze the incomplete markets equilibrium that exists when the monetary policymaker pursues a suboptimal policy, and show how an extension to more general preferences can limit the ability of the policymaker to provide full insurance to households in this setting.
The zinc finger proteins ZC3H20 and ZC3H21 stabilise mRNAs encoding membrane proteins and mitochondrial proteins in insect‐form Trypanosoma brucei
Authors: Liu Bin , Kamanyi Marucha Kevin , Clayton Christine 
Published: November 2019

AbstractZC3H20 and ZC3H21 are related trypanosome proteins with two C(x)8C(x)5C(x)3H zinc finger motifs. ZC3H20 is present at a low level in replicating mammalian‐infective bloodstream forms, but becomes more abundant when they undergo growth arrest at high density; ZC3H21 appears only in the procyclic form of the parasite, which infects Tsetse flies. Each protein binds to several hundred mRNAs, with overlapping but not identical specificities. Both increase expression of bound mRNAs, probably through recruitment of the MKT1‐PBP1 complex. At least 28 of the bound mRNAs decrease after depletion of ZC3H20, or of ZC3H20 and ZC3H21 together; their products include procyclic‐specific proteins of the plasma membrane and energy metabolism. Simultaneous depletion of ZC3H20 and ZC3H21 causes procyclic forms to shrink and stop growing; in addition to decreases in target mRNAs, there are other changes suggestive of loss of developmental regulation. The bloodstream‐form‐specific protein RBP10 controls ZC3H20 and ZC3H21 expression. Interestingly, some ZC3H20/21 target mRNAs also bind to and are repressed by RBP10, allowing for dynamic regulation as RBP10 decreases and ZC3H20 and ZC3H21 increase during differentiation.
Role of depressive symptoms in subjective memory complaint in older adults with mild cognitive impairment
Authors: Song Dan , Yu Doris S. F. , Li Polly W. C. , He Guijuan , Shen Cuizhen , Chen Guolin , Sun Qiuhua 
Published: November 2019

AbstractAimsTo explore the independent relationship between depressive symptoms and subjective memory complaint (SMC) amongst older adults with mild cognitive impairment (MCI) after adjusting for objective cognitive function and other important confounding factors.Backgroundsubjective memory complaint is a core symptom of MCI and is often the primary reason for older adults with MCI to seek for medical help. Improving subjective memory amongst older adults with MCI is important to enhance their quality of life and potentially delay further cognitive decline. Depressive symptoms, which are highly prevalent neuropsychiatric symptoms amongst older adults with MCI, may be one of the reasons that affect an individual's self‐perception of memory function. However, there is a dearth of studies to provide a thorough evaluation of the independent relationship between depressive symptoms and SMC amongst older adults with MCI.DesignA descriptive correlational study.MethodsA consecutive sample (N = 154) of adults aged over 60 years was recruited from a community healthcare centre between June and September 2016. MCI was detected using the Montreal Cognitive Assessment. Depressive symptoms and subjective memory were measured using the Geriatric Depression Scale and Memory Inventory for the Chinese, respectively. Hierarchical regression was performed to explore the relationship between SMC and depressive symptoms, with control over objective cognitive function, socio‐demographic and health‐related confounding factors.ResultsAfter controlling objective cognitive function and other confounding factors, SMC was independently associated with depressive symptoms (standardised β = 0.336, p < .001). This psychological status even explained for a greater variance (R2 = 8.8%) for SMC compared with objective cognitive function (R2 = 2.4%).Conclusionsubjective memory complaint was independently associated with depressive symptoms in older adults with MCI. Early detection and management of depressive symptoms are highly important amongst this clinical cohort.Implications for practiceEarly detection and prompt treatment of depressive symptoms is a highly prioritised care agenda in managing SMC in older adults with MCI.
The genetic architecture of vitiligo
Authors: Roberts Genevieve H. L. , Santorico Stephanie A. , Spritz Richard A. 
Published: November 2019

AbstractVitiligo is an autoimmune disease in which destruction of skin melanocytes results in patches of white skin and hair. Genome‐wide linkage studies and genome‐wide association studies in European ancestry cases identified over 50 vitiligo susceptibility loci, defining a model of melanocyte‐directed autoimmunity. Vitiligo heritability is exceedingly high, ~2/3 coming from common and ~1/3 from rare genomic variants; ~20% of vitiligo risk is environmental. Vitiligo genetic risk is polygenic, with greater additive risk in multiplex vitiligo families than simplex cases. Vitiligo age‐of‐onset is bimodal, also involving a major genetic component; a MHC enhancer haplotype confers extreme risk for vitiligo (OR 8.1) and early disease onset, increasing expression of HLA‐DQB1 mRNA and HLA‐DQ protein and thus perhaps facilitating presentation of triggering antigens. Vitiligo triggering also involves a major environmental component; dramatic delay in vitiligo age‐of‐onset, especially from 1973 to 2004, suggests that exposure or response to a key vitiligo environmental trigger diminished during this period. Together, these findings provide deep understanding of vitiligo pathogenesis and genetic architecture, suggesting that vitiligo represents a tractable model for investigating complex disease genetic architecture and predictive aspects of personalized medicine.
Plate-tectonic processes at ca. 2.0 Ga: Evidence from &gt;600 km of plate convergence
Authors: Yin An , Brandl Günther , Kröner Alfred 
Published: November 2019

Abstract
We addressed when plate-tectonic processes first started on Earth by examining the ca. 2.0 Ga Limpopo orogenic belt in southern Africa. We show through palinspastic reconstruction that the Limpopo orogen originated from &gt;600 km of west-directed thrusting, and the thrust sheet was subsequently folded by north-south compression. The common 2.7–2.6 Ga felsic plutons in the Limpopo thrust sheet and the absence of an arc immediately predating the 2.0 Ga Limpopo thrusting require the Limpopo belt to be an intracontinental structure. The similar duration (∼40 m.y.), slip magnitude (&gt;600 km), slip rate (&gt;15 mm/yr), tectonic setting (intracontinental), and widespread anatexis to those of the Himalayan orogen lead us to propose the Limpopo belt to have developed by continent-continent collision. Specifically, the combined Zimbabwe-Kaapvaal craton (ZKC, named in this study) in the west (present coordinates) was subducting eastward below an outboard craton (OC), which carried an arc equivalent to the Gangdese batholith in southern Tibet prior to the India-Asia collision. The ZKC-OC collision at ca. 2.0 Ga triggered a westward jump in the plate convergence boundary, from the initial suture zone to the Limpopo thrust within the ZKC. Subsequent thrusting accommodated &gt;600 km of plate convergence, possibly driven by ridge push from the west side of the ZKC. As intracontinental plate convergence is a key modern plate-tectonic process, the development of the Limpopo belt implies that the operation of plate tectonics, at least at a local scale, was ongoing by ca. 2.0 Ga on Earth.
Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer
Authors: Hu Yue-Xin , Zheng Ming-Jun , Zhang Wen-Chao , Li Xiao , Gou Rui , Nie Xin , Liu Qing , Hao Ying-Ying , Liu Juan-Juan , Lin Bei 
Published: November 2019

Abstract
Aim
Cervical cancer is a common malignant carcinoma of the gynecological tract with high morbidity and mortality. Therefore, it is crucial to elucidate the pathogenesis, prevention, diagnosis and prognosis of cervical cancer by searching for the involved key genes.

Method
In this study, the alternative splicing (AS) events of 253 patients with cervical cancer were analyzed, and 41,766 AS events were detected in 9961 genes. Univariate analysis was performed to screen prognostic AS events. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was used to identify the pathways in which these AS events were involved.

Results
We found that exon skip (ES) is the main AS event in patients with cervical cancer. There was pronounced consistency between the genes involved in overall survival and those involved in recurrence. At the same time, we found that a gene may exhibit several different types of AS events, and these different AS events may be related to prognosis. Four characteristic genes, HSPA14, SDHAF2, CAMKK2 and TM9SF1, that can be used as prognostic markers for cervical cancer were selected. Conclusion: The importance of AS events in the development of cervical cancer and prediction of prognosis was revealed by a large amount of data at the whole genome level, which may provide a potential target for cervical cancer treatment. We also provide a new method for exploring the pathogenesis of cervical cancer to determine clinical treatment and prognosis more accurately.
ESR statement on new approaches to undergraduate teaching in Radiology
Authors:   European Society of Radiology (ESR)
Published: November 2019

AbstractMedical education is evolving and electronic learning (e-Learning) strategies have now become an essential asset in radiology education. Radiology education is a significant part of the undergraduate medical curriculum and the use of e-Learning in radiology teaching in medical schools is on the rise. If coupled with clinical decision support systems, e-Learning can be a practical way of teaching students clinical decision making, such as selecting the diagnostic imaging tests that are best suited in certain clinical scenarios.The innovative concept of flipped classroom learning encourages students to work independently and maximises the application of learnt contents in interactive classroom sessions.For integrated curricula with their student-centred, problem-based, and community-based design, an approach to systematically integrate radiology may be to define diagnostic reasoning as one of the core goals. Radiologists as teachers and scholars may understand themselves as experts in diagnostic reasoning and in mentoring how to make medical decisions.Computer programs simulating the routine work are available and can be used to teach the recognition of anatomical structures and pathological patterns, and also to teach ultrasonography and interventional radiology, maximising patient safety.
Growth hormone deficiency in adults. Introduction to the problem
Authors: Bengt-Ake Bengtsson М. 
Published: November 2019

Growth hormone deficiency (GH) for a long time was recognized only in childhood. Compelling evidence has been obtained showing that HR replacement therapy effectively stimulates growth and, in many cases, achieves normal end-points of physical development. More recently, it was shown that the most effective in this regard was the appointment of regular evening injections of the drug, which mimic the physiological secretion of GH during sleep. Despite the fact that the acceleration of linear growth is the most objective criterion for the effectiveness of therapy for GH, it is known that GH has a significant effect on body structure, causing a decrease in fat mass and an increase in muscle mass.
Until recently, GH was not considered an important hormonal regulator in adults, and therefore, there was no study of GH deficiency and treatment of children with GH deficiency when they reached adulthood, as well as patients with hypopituitarism who became ill in adulthood. However, in 1989, as a result of two double-blind trials using placebo in the control group, the effectiveness of GH replacement therapy in adults with an abnormally low level of GH, up to a severe degree of GH deficiency, was revealed. Further studies showed the presence of violations of both physical and mental status in adults in whom GH deficiency develops as a result of the tumor process in the pituitary gland or its therapy. Most of these disorders, but not all, can be corrected as a result of GH replacement therapy, which confirms the significant effect of GH throughout life.
Increasing potato equivalent yield increases returns to investment under potato-legume intercropping systems
Authors: Gitari Harun I , Nyawade Shadrack O , Kamau Solomon , K Gachene Charles K. , Karanja Nancy N , Schulte-Geldermann Elmar 
Published: November 2019

Abstract
In order to enhance sustainable intensification of potato-based cropping systems, especially in sub-Saharan Africa (SSA), there is a need to investigate the economic viability of investing in this lucrative venture. This study evaluated the economic returns under legume intercropping systems using value/cost ratio (VCR) and benefit/cost ratio (BCR) under treatments comprising of potato intercropped with dolichos (Lablab purpureus L.) (P-D), climbing bean (Phaseolus vulgaris L.) (P-B) and garden pea (Pisum sativum L.) (P-G), and a potato pure stand control (P-S). Across the seasons, tuber yield was not significantly (p < 0.05) affected by intercropping with P-D, whereas under P-B and P-G, it decreased by 19% and 16%, respectively compared to P-S. P-G, P-B and P-D recorded 6, 7 and 12% higher potato equivalent yield (PEY) relative to P-S. P-D was the most profitable intercropping system with VCR of 35 and BCR of 5.1 as compared to values recorded in P-S of 31 and 5, respectively. Regression of VCR against PEY resulted in a stronger coefficient (0.98) compared to that of BCR against PEY (0.82) implying that VCR is a simple tool that could be adopted for economic returns to investment studies such as potato-legume inter-cropping systems.
An Activating Mutation in ERK Causes Hyperplastic Tumors in ascribbleMutant Tissue inDrosophila
Authors: Kushnir Tatyana , Bar-Cohen Shaked , Mooshayef Navit , Lange Rotem , Bar-Sinai Allan , Rozen Helit , Salzberg Adi , Engelberg David , Paroush Ze’ev 
Published: November 2019

AbstractExcessive RTK signaling, often caused by activating mutations in Ras, Raf and/or MEK, occurs in most human tumors. Intriguingly, confirmed cancer-driver mutations in the downstream effector kinase, ERK, have not been reported. To test if...Receptor tyrosine kinase signaling plays prominent roles in tumorigenesis, and activating oncogenic point mutations in the core pathway components Ras, Raf, or MEK are prevalent in many types of cancer. Intriguingly, however, analogous oncogenic mutations in the downstream effector kinase ERK have not been described or validated in vivo. To determine if a point mutation could render ERK intrinsically active and oncogenic, we have assayed in Drosophila the effects of a mutation that confers constitutive activity upon a yeast ERK ortholog and has also been identified in a few human tumors. Our analyses indicate that a fly ERK ortholog harboring this mutation alone (RolledR80S), and more so in conjunction with the known sevenmaker mutation (RolledR80S+D334N), suppresses multiple phenotypes caused by loss of Ras-Raf-MEK pathway activity, consistent with an intrinsic activity that is independent of upstream signaling. Moreover, expression of RolledR80S and RolledR80S+D334N induces tissue overgrowth in an established Drosophila cancer model. Our findings thus demonstrate that activating mutations can bestow ERK with pro-proliferative, tumorigenic capabilities and suggest that Drosophila represents an effective experimental system for determining the oncogenicity of ERK mutants and their response to therapy.
Tata laksana Pasien Gravida 29–30 Minggu dengan Gagal Napas ec. Hypokalemic Periodic Paralysis yang Diperberat dengan Community Acquired Pneumonia
Authors: Gunadi Mariko , Suwarman Suwarman , Kestriani S Nurita Dian 
Published: November 2019

Penatalaksanaan sakit kritis pada wanita hamil memiliki karakteristik yang unik karena perubahan fisiologi selama kehamilan dan janin yang berkembang dalam uterus yang mendapat implikasi yang signifikan. Pada kasus ini, seorang perempuan 27 tahun yang sedang hamil gemeli usia kehamilan 29–30 minggu datang ke Instalasi Gawat Darurat (IGD) Rumah Sakit Dr. Hasan Sadikin Bandung dengan keluhan utama kelemahan keempat anggota gerak. Hasil pemeriksaan laboratorium didapatkan kadar kalium sangat rendah dan didiagnosis dengan hypokalemic periodic paralysis. Pasien mengalami gagal napas sehingga dilakukan intubasi dan diberikan bantuan ventilasi mekanik, kemudian dirawat di Intensive Care Unit (ICU). Gagal napas disertai penyulit community acquired pneumonia. Tata laksana ventilasi mekanik pada wanita hamil di ICU bersifat suportif dengan teknik sama seperti pada pasien tidak hamil, namun memiliki target khusus yang berbeda. Monitoring fetal heart rate (FHR) dapat mencerminkan kesejahteraan janin dan kondisi ibu. Tujuan penulisan laporan kasus ini adalah mengetahui pentingnya target pemberian ventilasi mekanik dan melakukan monitoring FHR pada pasien hamil di ICU. Management of Respiratory Failure Due to Hypokalemic Periodic Paralysis Complicated with Community Acquired Pneumonia in 29–30 Weeks of GestationManagement of critically ill pregnant women in Intensive Care Unit (ICU) has unique characteristics due to the physiological changes during pregnancy and the presence of growing fetus in the uterine which may present significant implications. This study presented a case of a 27 years old woman with 29–30 weeks of gestation of twin pregnancy who came to Emergency Room (ER) with the chief complaint of weakness in both lower and upper extremities. Laboratory investigations showed a very low potassium level and the patient was diagnosed with hypokalemic periodic paralysis. Patient then experienced respiratory failure at the ER, intubated, and mechanically ventilated and was sent to the ICU. Community-acquired pneumonia was complicating the respiratory failure. Basically, mechanical ventilation management for pregnant patient in ICU is supportive in nature and uses the same techniques employed for the non-pregnant patient. However, the goals are different as it is important to monitor fetal heart rate (FHR) in pregnant woman as this does not only reflect the fetal well-being but also the maternal condition. This case report is intended to show the importance of mechanical ventilation goal and FHR monitoring in pregnant patients in ICU.
Holocene Rupture History of the Central Teton Fault at Leigh Lake, Grand Teton National Park, Wyoming
Authors: Zellman Mark S. , DuRoss Christopher B. , Thackray Glenn D. , Personius Stephen F. , Reitman Nadine G. , Mahan Shannon A. , Brossy Cooper C. 
Published: November 2019

ABSTRACTProminent scarps on Pinedale glacial surfaces along the eastern base of the Teton Range confirm latest Pleistocene to Holocene surface-faulting earthquakes on the Teton fault, but the timing of these events is only broadly constrained by a single previous paleoseismic study. We excavated two trenches at the Leigh Lake site near the center of the Teton fault to address open questions about earthquake timing and rupture length. Structural and stratigraphic evidence indicates two surface-faulting earthquakes at the site that postdate deglacial sediments dated by radiocarbon and optically stimulated luminescence to ∼10–11  ka. Earthquake LL2 occurred at ∼10.0  ka (9.7–10.4 ka; 95% confidence range) and LL1 at ∼5.9  ka (4.8–7.1 ka; 95%). LL2 predates an earthquake at ∼8  ka identified in the previous paleoseismic investigation at Granite Canyon. LL1 corresponds to the most recent Granite Canyon earthquake at ∼4.7–7.9  ka (95% confidence range). Our results are consistent with the previously documented long-elapsed time since the most recent Teton fault rupture and expand the fault’s earthquake history into the early Holocene.