bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols
Authors: Egnell Christina , Ranta Susanna , Banerjee Joanna , Merker Andrea , Niinimäki Riitta , Lund Bendik , Mogensen Pernille Rudebeck , Jonsson Ólafur G. , Vaitkeviciene Goda , Lepik Kristi , Forslund Anders , Heyman Mats , Harila‐Saari Arja 
Published: September 2020

AbstractObjectivesHigh body mass index (BMI) is associated with poorer survival in childhood acute lymphoblastic leukemia (ALL), but the actual impact on the risk of relapse still needs to be clarified. We evaluated the impact of BMI at diagnosis on the risk of relapse in children with ALL treated according to Nordic Society of Paediatric Haematology and Oncology (NOPHO) protocols.MethodIn a multicenter study, we collected data on BMI at diagnosis and outcome of 2558 children aged 2.0‐17.9 years diagnosed between 1992 and 2016. Patients were divided into four groups according to International Obesity Task Force (IOTF) childhood BMI cut‐offs: underweight, <17; healthy weight, 17‐25; overweight, 25‐30; and obese, ≥30 kg/m2.ResultsIn Cox multivariate regression analyses, an increased risk of relapse was observed in children aged 10‐17.9 years with unhealthy BMI at diagnosis (underweight hazard ratio HR: 2.90 [95% confidence interval: 1.24‐6.78], P = .01; overweight, HR: 1.95 [1.11‐3.43], P = .02, and obese HR: 4.32 [95% 2.08‐8.97], P < .001), compared to children with healthy weight. BMI had no impact on relapse in children under 10 years of age.ConclusionHigh BMI, and especially obesity at diagnosis, is an independent adverse prognostic factor for relapse in older children with ALL.
Breaking down experience—Heidegger's methodological use of breakdown in Being and Time
Authors: Ward Katherine 
Published: September 2020

AbstractPhenomenologists draw on descriptions of experience to uncover the conditions that enable experience. However, a second‐order or distanced view of experience can distort it. In his analysis of the ready‐to‐hand, Heidegger utilizes experiences of breakdown to avoid this problem, but he does not provide a detailed account of why this methodology is effective. I use Heidegger's analysis of interpretation to reconstruct a detailed account of the breakdown methodology and show why it avoids the problem of “observation distortion.” Although Heidegger is only explicit about his use of this methodology in the analysis of the ready‐to‐hand, I show that analyses of breakdown experiences are implicit throughout Being and Time and have an important role in two key moments of the analysis of Dasein: Being‐with (publicness) and Dasein's structural whole (care).
Attended vs unattended systolic blood pressure measurement: A randomized comparison in patients with cardiovascular disease
Authors: Keeley Ellen C. , Villanueva Matthew , Chen Yiqing E. , Gong Yan , Handberg Eileen M. , Smith Steven M. , Pepine Carl J. , Cooper‐DeHoff Rhonda M. 
Published: September 2020

AbstractRecent clinical guidelines recommend lower blood pressure (BP) goals for most patients, and recent trends have favored use of automated unattended BP measurements in the office setting to minimize observer error and white‐coat effects. Patients attending a routinely scheduled CVD clinic visit were prospectively randomized to BP measured using an attended, followed by an unattended method, or vice versa, after a controlled rest period. All study BP measurements were obtained in triplicate using the automated Omron HEM‐907XL BP monitor, and averaged. The outcome was difference in SBP. Routinely measured clinic BP from the same visit was extracted from the medical record, and compared with attended and unattended BP. A total of 102 patients were randomized, and mean age was 63 years, 52% female and 75% Caucasian. Attended and unattended SBP was 125.4 ± 20.4 and 122.6 ± 21.0 mm Hg, mean ± SD, respectively. Routine clinic SBP was 130.6 ± 23.6 mm Hg. Attended SBP was 2.7 mm Hg higher than the unattended measurement (95% CI 1.3‐4.1; P = .0002). Routine clinic SBP was 5.2 mm Hg higher than attended SBP (95% CI 2.4‐8.0; P = .0003) and 8.0 mm Hg higher than unattended SBP (95% CI 5.4‐10.5; P < .0001). Attended measurement of BP is significantly higher than unattended measurement and the difference is physiologically meaningful, even in a CVD cohort with generally well‐controlled hypertension. Furthermore, routine clinic SBP substantially overestimates both attended and unattended automated SBP, with important implications for treatment decisions like dose and/or drug escalation.
The longitudinal association between externalizing behavior and frontoamygdalar resting‐state functional connectivity in late adolescence and young adulthood
Authors: Thijssen Sandra , Collins Paul F. , Weiss Hannah , Luciana Monica 
Published: September 2020

BackgroundExternalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala–anterior cingulate cortex (ACC) and amygdala–orbitofrontal cortex (OFC) resting‐state functional connectivity in a sample of 111 typically developing participants aged 11–23 at baseline.MethodsParticipants completed two‐to‐four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self‐Report questionnaire. Resting‐state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala–ACC/OFC functional connectivity was examined using linear mixed effect models in R.ResultsExternalizing behavior was associated with increased amygdala–ACC and amygdala–OFC resting‐state functional connectivity across adolescence and young adulthood. For amygdala–ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala–OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala–OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age‐by‐externalizing behavior interaction effect).ConclusionsHigher externalizing behavior is associated with increased resting‐state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control.
Assessment of spawning site fidelity in interior Fraser River Coho salmon Oncorhynchus kisutch using otolith microchemistry, in British Columbia, Canada
Authors: Turcotte Luc A. , Shrimpton J. Mark 
Published: September 2020

AbstractCoho Salmon Oncorhynchus kisutch show fidelity to natal spawning watersheds. Fine‐scale homing, however, within rivers is not well understood. Interior Fraser Coho (IFC) salmon eggs were incubated at known spawning locations in the Coldwater River, two main stem sites and one‐off channel pond site, providing otolith reference data for comparison to otolith signatures for returning adults using laser ablation inductively coupled plasma mass spectrometry. Elemental ratios for Ba:Ca and Sr:Ca in otoliths of juvenile O. kisutch differed significantly among the spawning locations examined. Juvenile otolith data were used to conduct a linear discriminant analysis to assess fine‐scale homing in adults. Juvenile data were all assigned to the location where they had been incubated, producing a robust data set used to compare adult otoliths and define natal locations based on elemental signatures in otoliths of adult spawners. Homing and straying were apparent at the reach level; 57.1% of adults returned to their natal spawning locations, while 42.9% strayed to other spawning sites within the Coldwater River. Straying to novel incubation sites at the reach scale demonstrated plasticity in homing within a watershed.
Socioeconomic Risk for Adolescent Cognitive Control and Emerging Risk‐Taking Behaviors
Authors: Brieant Alexis , Peviani Kristin M. , Lee Jacob E. , King‐Casas Brooks , Kim‐Spoon Jungmeen 
Published: September 2020

This study examined whether cognitive control mediated the association between socioeconomic status (SES; composite of income‐to‐needs ratio and parent education) and changes in risk‐taking behaviors. The sample included 167 dyads of adolescents (53% male; Mage = 14.07 years at Time 1) and their parents, assessed annually across 4 years. Parents reported socioeconomic variables at Time 1. Adolescents reported risk‐taking behaviors at Times 1 and 4, and completed a functional magnetic resonance imaging cognitive control task at Times 2 and 3. Lower SES was associated with lower behavioral (but not neural) cognitive control, which was associated with increases in risk‐taking behaviors. The findings suggest that elevated socioeconomic risk may compromise cognitive control which can cascade into maladaptive behaviors in adolescence.
Factors affecting woodland rodent growth
Authors: Brouard M. J. , Knowles S. C. L. , Dressen S. , Coulson T. , Malo A. F. 
Published: September 2020

AbstractVery little information exists on the growth rates of woodland rodents and the drivers of body size dynamics that are observed in British populations. In this study, we use mark–recapture data collected on two species living in sympatry, wood mice (Apodemus sylvaticus) and bank voles (Myodes glareolus). A third species of rodent, the yellow‐necked mouse (Apodemus flavicollis) was also caught occasionally. We found the density of this third species negatively impacted the growth rate of both wood mice and bank voles. No impact of conspecific population density on growth for either species was found. Previous studies have suggested high conspecific population density can impact growth for some individuals of the population, but our populations may have not reached the densities required to elucidate these effects during the study.
A hole in the nematosphere: tardigrades and rotifers dominate the cryoconite hole environment, whereas nematodes are missing
Authors: Zawierucha K. , Porazinska D. L. , Ficetola G. F. , Ambrosini R. , Baccolo G. , Buda J. , Ceballos J. L. , Devetter M. , Dial R. , Franzetti A. , Fuglewicz U. , Gielly L. , Łokas E. , Janko K. , Novotna Jaromerska T. , Kościński A. , Kozłowska A. , Ono M. , Parnikoza I. , Pittino F. , Poniecka E. , Sommers P. , Schmidt S. K. , Shain D. , Sikorska S. , Uetake J. , Takeuchi N. 
Published: September 2020

AbstractThe worldwide distribution of microinvertebrates on glaciers, the coldest biome, is poorly known. Owing to their tolerance to hostile conditions, small size and dispersal abilities, nematodes, tardigrades and rotifers are considered cosmopolitan and together inhabit various ecosystems. In this study, we investigated their global distribution in cryoconite holes – a type of freshwater reservoir forming directly in the glacial ice that creates biodiversity hotspots on glaciers. We analysed cryoconite samples (using classical microscopic observations and environmental DNA metabarcoding) from 42 glaciers located around the world (the Arctic, Subarctic, Scandinavia, the Alps, the Caucasus, Siberia, Central Asia, Africa, South America and Antarctica), as well as using literature data. Samples from Antarctic, Karakoram and the Alps were analysed using next‐generation sequencing (NGS) and classical observations under microscopes, while all other samples were analysed by microscope alone. Three general outcomes were found: (1) tardigrades and rotifers represented the most common invertebrates in cryoconite holes; (2) tardigrades and rotifers often coexisted together, with one or the other dominating, but the dominant taxon varied by region or by glacier; (3) nematodes – the most abundant, hyperdiverse and widespread metazoans on Earth, including in environments surrounding and seeding glacial surfaces – were consistently absent from cryoconite holes. Despite the general similarity of environmental conditions in cryoconite holes, the distribution of tardigrades and rotifers differed among glaciers, but not in any predictable way, suggesting that their distribution mostly depended on the random dispersal, extreme changes of supraglacial zone or competition. Although nematodes have been found in supraglacial habitats, cryoconite hole environments seem not to provide the necessary conditions for their growth and reproduction. Lack of physiological adaptations to permanently low temperatures (~0°C) and competition for different food resources in the cryoconite hole environment may explain the absence of nematodes in cryoconite holes.
The La Marca model revisited: Structuralist goodwin cycles with evolutionary supply side and balance of payments constraints
Authors: Spinola Danilo 
Published: September 2020

AbstractThis research is aimed at investigating the causes of volatility that affect middle‐income countries by studying the La Marca model. Drawing from the open‐economy Goodwin tradition, this model demonstrates that economic activity, income distribution and accumulation of foreign assets dynamically interact, resulting in a pattern of dampened cycles. The study consists in analyzing the characteristics of the model by initially imposing: (I) a constant real exchange rate; (II) a constant net external asset to capital ratio, which is in line with the balance of payments dominance theory and (III) a fixed income distribution. We then (IV) expand the original model by adding an evolutionary supply‐side in which productivity is at the center of the economic dynamic through international technology transfer and the Kaldor‐Verdoorn effect. The results show that (1) the model always converges. (2) The restrictions (I) and (II) remove the cyclical component of the model, which highlights a central difference between La Marca and the original Goodwin model. (3) Fixed income distribution leads to a monotonic trajectory that reduces oscillations. (4) The inclusion of productivity dynamics generates new sources of volatility in the relationship between productivity, capacity utilization and net external assets and is in line with the structuralist argument of structural fragility.
Efficacy of omalizumab treatment for pediatric chronic spontaneous urticaria: A multi‐center retrospective case series
Authors: Ari Anne , Levy Yael , Segal Nirit , Maoz‐Segal Ramit , Benor Shira , Broides Arnon , Horev Amir , Epstein‐Rigbi Na'ama , Agmon‐Levin Nancy , Marcus Nufar 
Published: September 2020

AbstractBackgroundChronic urticaria is defined by the presence of itchy wheals, sometimes accompanied by angioedema, lasting for at least 6 weeks. In children, most cases occur without an eliciting factor and are defined as chronic spontaneous urticaria (CSU). CSU affects up to 0.75% of children with a negative impact on quality of life and school performance. CSU is treated in adults with second‐generation antihistamines, increased up to four times normal doses for second‐line treatment. Omalizumab (a monoclonal antibody to IgE) may be recommended as third‐line therapy. A similar protocol is used in children, yet little is known of its efficacy and safety.ObjectivesTo summarize our multi‐center experience in treating children with recalcitrant CSU with omalizumab.MethodsA retrospective multi‐center case series conducted in 5 tertiary care centers in Israel. Patients included were children <18 years old diagnosed with recalcitrant CSU who were treated with omalizumab. Patients were followed up throughout the duration of omalizumab therapy/symptom remission. Patients' electronic medical records were used to gather data.ResultsNineteen participants (11 F; 8 M) presented with CSU between ages 6 and 16.9 years. Sixteen (84%) responded to omalizumab, including children <12 years old, although two became non‐responsive after 6‐12 months of therapy. Another three patients (16%) were resistant to treatment, achieving remission through fourth‐line (Cyclosporine A) or other therapies.ConclusionChildren with recalcitrant CSU, even those <12 years old, respond well to standard‐dose, third‐line omalizumab therapy at rates similar to adults. Yet, some cases may become non‐responsive with ongoing treatment.
Living at Extractive Sites: Invisible Harm and Green Victimization in the Oil Fields*
Authors: Opsal Tara , Luzbetak Austin , O'Connor Shelley Tara 
Published: September 2020

AbstractOil and natural gas activity has grown dramatically over the last decade around the United States because, in part, of increased use of unconventional technologies like hydraulic fracturing. Social scientists have examined the broad array of impacts of this growth to communities disproportionately impacted by activity. This paper contributes to that work by using survey and qualitative interviews to examine the experiences of Coloradans with harm created by oil and gas activity when they live adjacent to production or extraction sites. Using a green criminological and critical criminological framing, our findings illuminate that Coloradans in these samples experienced persistent and patterned harm from oil and gas activity to which they lived proximate. Additionally—paralleling criminological literature on street crime—our findings indicate that official state records on harm prevalence is likely inaccurate and that, instead, a “dark figure” of harm exists. This results because of underreporting of harm by those who experience it which occurs in part, at least for those in our sample, because of a lack of trust or sense of fairness in the regulatory process.
Elimination of pretransfusion RhD typing at Mackay Memorial Hospital, Taiwan—30‐year experience (1988–2017)
Authors: Lin Marie 
Published: September 2020

BackgroundThe frequency of the RhD negative (D‐) phenotype among the population of Taiwan is only 0·34% and so anti‐D is a relatively rare antibody. Routine pretransfusion D typing of patients at Mackay Memorial Hospital (MMH) was discontinued in 1988, and this report is a look back and retrospective evaluation over 30‐years (1988–2017).Study Design and MethodsThe incidence of anti‐D among patients at MMH during the periods 1984–1988 (when D typing was performed) and 1988–2017 (when D typing was not performed) was reviewed. Also, the incidence of anti‐D among both MMH patients and voluntary blood donors at the Taiwan Blood Foundation was compared. The importance of anti‐‘Mia’ in Taiwan is also discussed.ResultsThe incidence of anti‐D relative to other Rh antibodies among MMH patients when D typing was performed and D typing not performed has remained relatively unchanged (5%). The frequencies of anti‐D and anti‐‘Mia’ among 38 537 patients who were transfused at MMH during 2008–2017 were found to be 0·06% and 2·6%, respectively. During the same period, among 3 510 131 blood donors at Taiwan Blood Foundation, the frequencies of anti‐D and anti‐‘Mia’ were 0·004% and 0·2%, respectively.ConclusionThe elimination of D typing of patients at MMH has proven to have been a correct and logical decision. D‐ patients, if they do not carry anti‐D, can thus be safely transfused with D+ red cells.
Children’s Worth School: Psychological Well-Being of High School Students in Padang
Authors: Afnibar Afnibar , Amalia Amalia , Nasrul Dyla Fajhriani , Rahmi Aulia 
Published: September 2020

This study aimed to reveal the condition of a child-friendly school as seen from the psychological well-being students in school. Lately there have been various harassment incidents that have befallen students and their own culprit; this is allegedly related to their discomfort at school. Interviews and observations were employed in this study. The participants which were the public high school students were recruited and determined by snowball sampling. The results showed that, generally, students experienced problems; first, psychological well-being was disrupted due to the following reasons: (1) learning environment which included incomplete classroom and extracurricular activities facilities; (2) teachers’ attribute which included attitudes toward students, show less affection, appreciation and sometimes like to force the will; and (3) inadequate teaching and learning aspects which included poor lesson plans and dense of teaching and learning material. Second, psychological well-being felt by students generally in schools is related to: (1) the atmosphere in the classroom: friendly and not grumpy teachers, fun teachers in explaining the lesson; (2) understanding and easygoing friends who are comfortable to communicate with, and (3) the atmosphere outside the classroom, friendly waiters in the canteen and a comfortable and quiet library.
Problemas a la salud que provoca la exposición al polvo de harina
Authors: Pimienta Cortes Angelica Sumaya , Ramírez Oliveros Erika Patricia , De la Caridad Montero Ricardo 
Published: September 2020

Las diversas enfermedades producidas por material particulado, en especial aquellas que se generan como resultado de la exposición al polvo de harina; muy común en los panaderos y que es un factor del desarrollo del “asma del panadero”.
En el artículo se describen los efectos generados por las panaderías hacia los panaderos debido a la exposición del polvo de harina, generándoles posibles enfermedades respiratorias, reacciones alérgicas al sistema respiratorio y síndromes respectivos; como medidas de prevención se recomienda la utilización de sistemas de extracción del polvo de harina que permiten minimizar las enfermedades respiratorias, en especial el asma ocupacional
BANYUWANGI: KOTA FESTIVAL MENUJU DESTINASI WISATA INDONESIA DAN DUNIA
Authors: Purwowibowo Purwowibowo 
Published: September 2020

Abstract
Tourism has become a leading sectors of Banyuwangi Regency to realize the social welfare of the whole communities. This can be seen from the program that was launched by this district to become a major program and important tourist destination in Indonesia, not only for local tourists but also foreign tourists. In fact, the last 5 years the Banyuwangi Regency has made a program that is believed to be an effort to boost tourism activities on a massive scale. The program is a festival, which are a program designed and implemented by all local government officials and supported by the all communities. In 2019, the number of festivals held was 99 activities, one of which is the phenomenal festival that is the 'Gandrung Sewu Festival'. With so many festivals, Banyuwangi and then that city was called and becomes the 'City of Festivals'.
Keywords: Banyuwangi, Tourism, Social Welfare, Festival City, Gandrung Sewu