bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing electronic decision-support tools to strengthen healthcare network data-driven decision-making
Authors: Rios-Zertuche Diego , Gonzalez-Marmol Alvaro , Millán-Velasco Francisco , Schwarzbauer Karla , Tristao Ignez 
Published: June 2020

Abstract
Background
Ministries of health in low- and middle-income countries often lack timely quality data for data-driven decision making in healthcare networks. We describe the design and implementation of decision-support electronic tools by the Ministry of Health of the State of Chiapas, in Mexico, as part of Salud Mesoamerica Initiative.

Methods
Three electronic decision-support tools were designed through an iterative process focused on streamlined implementation: 1) to collect and report health facility data at health facilities; 2) to compile and analyze data at health district and central level; and, 3) to support stratified sampling of health facilities. Data was collected for five composite indicators measuring availability of equipment, medicines, and supplies for maternal and child health. Quality Assurance Teams collected data, evaluated results and supported quality improvement. Data was also analyzed at the central level and health districts for decision-making.

Results
Data from 300 health facilities in four health districts was collected and analyzed (November 2014—June 2015). The first wave revealed gaps on availability of equipment and supplies in more than half of health facilities. Electronic tools provided the ministry of health officers new ways to visualize data, identify patterns and make hypothesis on root-causes. Between the first and second measurement, the number of missing items decreased, and actions performed by quality improvement teams became more proactive. In the final measurement, 89.7—100% of all health facilities achieved all the required items for each indicator.

Conclusions
Our experience could help guide others seeking to implement electronic decision-support tools in low- and middle-income countries. Electronic decision-support tools supported data-driven decision-making by identifying gaps on heatmaps and graphs at the health facility, subdistrict, district or state level. Through a rapid improvement process, the Ministry of Health met targets of externally verified indicators. Using available information technology resources facilitated prompt implementation and adoption of technology.
Cigarette smoking and schizophrenia: Mendelian randomisation study
Authors: Chen Jianhua , Chen Ruirui , Xiang Siying , Li Ningning , Gao Chengwen , Wu Chuanhong , Zhang Qian , Zhao Yalin , Liao Yanhui , Stewart Robert , Xu Yifeng , Shi Yongyong , Li Zhiqiang 
Published: June 2020

BackgroundThe link between schizophrenia and cigarette smoking has been well established through observational studies. However, the cause–effect relationship remains unclear.AimsWe conducted Mendelian randomisation analyses to assess any causal relationship between genetic variants related to four smoking-related traits and the risk of schizophrenia.MethodWe performed a two-sample Mendelian randomisation using summary statistics from genome-wide association studies (GWAS) of smoking-related traits and schizophrenia (7711 cases, 18 327 controls) in East Asian populations. Single nucleotide polymorphisms (SNPs) correlated with smoking behaviours (smoking initiation, smoking cessation, age at smoking initiation and quantity of smoking) were investigated in relation to schizophrenia using the inverse-variance weighted (IVW) method. Further sensitivity analyses, including Mendelian randomisation-Egger (MR-Egger), weighted median estimates and leave-one-out analysis, were used to test the consistency of the results.ResultsThe associated SNPs for the four smoking behaviours were not significantly associated with schizophrenia status. Pleiotropy did not inappropriately affect the results.ConclusionsCigarette smoking is a complex behaviour in people with schizophrenia. Understanding factors underlying the observed association remains important; however, our findings do not support a causal role of smoking in influencing risk of schizophrenia.
Are charity galas still relevant? An examination of generational differences in attitudes towards gala fundraising events
Authors: Fairbairn Fiona 
Published: June 2020

Prompted by the scandal in 2018 concerning sexist behaviour at the Presidents Club’s charity gala in London in the UK and by the emerging literature within the field of philanthropy that finds generational differences in donor motivation and behaviour, this study examines whether the charity gala continues to be a relevant method of fundraising.
Taking a mixed-methods research approach, using surveys and interviews, the study captures the views and attitudes of 108 affluent donors and 53 fundraisers in the UK. Aside from a few minor differences, the study finds that donors across generations share similar attitudes towards galas, concluding that this fundraising method is still relevant, providing the charities have willing supporters with appropriate social networks.
The findings, of interest to scholars and practitioners alike, address a gap in empirical evidence regarding donor attitudes towards a specific type of fundraising as well as contributing to the broader discussion as to why people engage with philanthropy.
Efectos del estrés hídrico en crecimiento y desarrollo fisiológico de <i>Gliricidia sepium</i> (Jacq.) Kunth ex Walp.
Authors: Valverde Otárola Juan Carlos , Arias Dagoberto 
Published: June 2020

El estrés hídrico es una reacción fisiológica de las plantas ante la disponibilidad limitada de agua. Este estudio valoró el efecto del estrés en plántulas de Gliricidia sepium cultivadas en condiciones de invernadero, utilizando plantas testigo y dos tipos de estrés (lineal y cíclico). El estrés generó reducciones en el crecimiento en altura del 30 % y de la lámina foliar del 40 %. Las plantas con estrés lineal mostraron a los 98 días un estrés severo con valores fisiológicos mínimos (fotosíntesis 4.51 µmol m-2.s-1, transpiración 6.56 µmol m-2.s-1, conductancia 48.6 µmol m-2.s-1); en cambio, las plantas con estrés cíclico si bien se expusieron a un estrés moderado, mostraron recuperación con valores fisiológicos finales estables (fotosíntesis 12.96 µmol m-2.s-1, transpiración 6.22 µmol m-2.s-1, conductancia 196.05 µmol m-.2s-1), con un retardo del crecimiento del 30 % con respecto a las plantas testigo, encontrando que en 42 días de estrés la condición es grave.
Evaluation of production conditions of tomato grafted with different tobacco rootstocks and determining nicotine content and quality of fruit
Authors: TUNÇAY ÇAĞATAY Seda , ÇALIK KOÇ Gülşah , REZAEİ Fereshteh , DARCANSOY İŞERI Özlem , ŞAHIN Feride İffet , HABERAL Mehmet 
Published: June 2020

This study aimed to investigate the effects of grafting tomato on different tobacco rootstocks on quality factors and nicotine content. The commercial variety (Solanum lycopersicum ‘H2274’) (BIOTECH) of the tomato was used as the scion plant, and six different tobacco (Nicotiana tabacum L.) rootstocks were used: Taşova, Tekel, Muş, Samsun, Dişbudak, Hasankeyf cultivars. Cleft grafting method was used in all plants. Yield of non-grafted and grafted plants grown in open-field conditions was calculated, and there was a significant increase in yield in grafted tomatoes compared to non-grafted tomatoes. There was significantly increased lycopene and β-carotene levels (mg kg-1), especially in ‘Tekel’, ‘Taşova’, ‘Samsun’, and ‘Hasankeyf’ tobacco grafts. There was a statistically significant difference between grafted and non-grafted plants according to 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical retention capacities and total phenol (TP) values. Evaluation of quality determinants including pH values, titratable acidity values (citric acid %), soluble solid content (SSC)(oBrix) , fruit size ratios, showed that tomatoes grafted with ‘Muş’ tobacco rootstock were of higher quality. There was no significant difference between grafted and non-grafted plants according to nicotine analysis of the tobacco-grafted tomatoes, and due to acceptable ranges of nicotin level on tobacco grafted tomato plants were considered to be suitable for consumption. It could be concluded that grafting practices have significantly positive effects on tomato yield and quality.
Overlapping but Distinct Sequences Play Roles in the Insulator and Promoter Activities of the Drosophila BEAF-Dependent scs’ Insulator
Authors: Maharjan Mukesh , McKowen J Keller , Hart Craig M 
Published: June 2020

Abstract
Chromatin domain insulators are thought to help partition the genome into genetic units called topologically associating domains (TADs). In Drosophila, TADs are often separated by inter-TAD regions containing active housekeeping genes and associated insulator binding proteins. This raises the question of whether insulator binding proteins are involved primarily in chromosomal TAD architecture or gene activation, or if these two activities are linked. The Boundary Element-Associated Factor of 32 kDa (BEAF-32, or BEAF for short) is usually found in inter-TADs. BEAF was discovered based on binding to the scs’ insulator, and is important for the insulator activity of scs’ and other BEAF binding sites. There are divergent promoters in scs’ with a BEAF binding site by each. Here, we dissect the scs’ insulator to identify DNA sequences important for insulator and promoter activity, focusing on the half of scs’ with a high affinity BEAF binding site. We find that the BEAF binding site is important for both insulator and promoter activity, as is another sequence we refer to as LS4. Aside from that, different sequences play roles in insulator and promoter activity. So while there is overlap and BEAF is important for both, insulator and promoter activity can be separated.
“PLACES OF MEMORY” TRANSFORMATION IN POST-SOVIET KYIV’S CULTURAL PLACES A CASE OF JANUARY UPRISING STREET
Authors: Prymachenko Yana 
Published: June 2020

The article deals with the transformation of “places of memory” in post-Soviet Kyiv’s cultural space based on the case of January Uprising Street. The main attention focuses on three events crucial for Ukrainian history in the twentieth century: the 1917–1921 Ukrainian Revolution, Holodomor and the Second World War. The author highlights the change in the ideological connotation and cultural representations of Soviet “places of memory” during almost thirty years of Ukrainian independence.
The former January Uprising Street, which today consists of two streets – Ivan Mazepa and Lavrska – would for a long period of time signify the key events of Soviet history: October Revolution Civil war and World War II. The Park of Eternal Glory and Memorial complex “Ukrainian State Museum of the History of the Great Patriotic War of 1941–1945” (now known as the National Museum of the history of Ukraine in the Second World War) built into the historical space pf the ancient Kyiv had to propagate the main Soviet historical event. After Ukraine gained independence the space along the former January Upraising Street has transformed greatly. The public space has been affected by the rediscovery of forgotten and erased events.
Fluks Co2 di Perairan Pesisir Timur Pulau Bintan, Propinsi Kepulauan Riau
Authors: R. Fachri Faridz , - Afdal , Sartimbul A. , Hidayati N. 
Published: June 2020

Proses pertukaran CO2 yang terjadi antara permukaan air laut dengan atmosfer merupakan aspek yang penting terhadap siklus karbon di samudera. Wilayah pesisir memiliki kontribusi besar dalam proses ini, karena kompleksnya interaksi yang terjadi antara atmosfer, daratan dan lautan. Proses penting dalam dinamika gas CO2 antara atmosfer dan air laut diawali dengan fungsi daya larut CO2 dan kecepatan transfer gas CO2 di permukaan laut atau disebut fluks CO2. Penelitian ini bertujuan untuk mengetahui fenomena fluks CO2 antara permukaan air laut dengan atmosfer di pesisir timur Pulau Bintan beserta komponen sink dan source-nya, serta mengetahui parameter yang paling dominan terhadap proses tersebut, meliputi parameter fisika-kimia oseanografi, serta parameter sistem CO2 pada kurun waktu 16-18 Maret 2013. Permodelan OCMIP digunakan untuk mengidentifikasi nilai pCO2 air laut dalam penentuan nilai fluks CO2. Hasil analisis menunjukkan secara kesuluruhan perairan pesisir timur Pulau Bintan berperan sebagai penyerap CO2 (sink) dengan rata-rata emisi CO2 dari atmosfer yang masuk ke wilayah permukaan laut sebesar -0,43mmolC/m2/hari. Analisis statistik Principal Component Analysis (PCA) menunjukkan parameter yangdominan terhadap perubahan nilai fluks CO2 adalah salinitas, konsentrasi Dissolved Inorganic Carbon (DIC), pCO2 air laut, serta nilai selisih tekanan parsial CO2 antara air laut dengan atmosfer (ΔpCO2). Kondisi fluks CO2 di pesisir timur Pulau Bintan lebih dipengaruhi oleh variasi musim dan dinamika oseanografi perairan Natuna serta Laut Cina Selatan dibandingkan dengan pengaruh dari daratan.
ALK-Rearranged Non-Small Cell Lung Cancer in 2020: Real-World Triumphs in an Era of Multigeneration ALK-Inhibitor Sequencing Informed by Drug Resistance Profiling
Authors: Itchins Malinda , Lau Brandon , Hudson Amanda L. , Westman Helen , Xia Cathy Yi , Hayes Sarah A. , Howell Viive M. , Rodriguez Michael , Cooper Wendy A. , Wei Heng , Buckland Michael , Li Bob T. , Li Mark , Rathi Vivek , Fox Stephen B. , Gill Anthony J. , Clarke Stephen J. , Boyer Michael J. , Pavlakis Nick 
Published: June 2020

Abstract

Since its discovery in 2007, we have seen the lives of patients diagnosed with advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancers (NSCLC) transform with the advent of molecular therapies with first-, second-, and third-generation ALK inhibitors now available in the clinic. Despite great gains in patient survival now measured in years and preserved quality of life with targeted therapies, drug resistance is unfortunately inevitably encountered in this rare and unique molecular subset of lung cancer, and patients will eventually succumb to the disease. As these patients are often young, fit, and never smokers, the clinical and scientific communities have aligned to expedite drug development and access. Drug resistance profiling and further strategies are being explored through clinical trials, including the evaluation of specific drug sequencing and combinations to overcome such resistance and promote patient longevity. The cases of this report focus on precision medicine and aim to portray the pertinent aspects to consider when treating ALK-rearranged NSCLC in 2020, an ever-shifting space. By way of case examples, this report offers valuable information to the treating clinician, including the evolution of systemic treatments and the management of oligo-progression and multisite drug resistance. With the maturation of real-world data, we are fortunate to be experiencing quality and length of life for patients with this disease surpassing prior expectations in advanced lung cancer.

Key Points
This report focuses on the importance of genetic analysis of serial biopsies to capture the dynamic therapeutic vulnerabilities of a patient's tumor, providing a perspective on the complexity of ALK tyrosine kinase inhibitor (ALKi) treatment sequencing. These case examples contribute to the literature on ALK-rearranged and oncogene addicted non-small cell lung cancer (NSCLC), providing a framework for care in the clinic. In oligo-progressive disease, local ablative therapy and continuation of ALKi postprogression should be considered with potential for sustained disease control. ALK G1202R kinase domain mutations (KDM), highly prevalent at resistance to second-generation ALKi resistances, may emerge in non-EML4-ALK variant 3 cases and is sensitive to third-generation lorlatinib. When in compound with one or more ALK KDMs, resistance to lorlatinib is expected. In the case of rampantly progressive disease, rebiopsy and redefining biology in a timely manner may be informative.
FİNANSAL PİYASALARDA PAY SENEDİ MANİPÜLASYONU’NUN VERİ MADENCİLİĞİ YÖNTEMLERİ İLE TAHMİNİ: BORSA İSTANBUL ÖRNEĞİ
Authors: AKSOY Barış 
Published: June 2020

Bu
çalışmada Borsa İstanbul İmalat Sanayi sektöründe faaliyet gösteren 51 manipüle
edilmiş ve 51 manipüle edilmemiş toplam 102 işletmeye ait pay senedinin 3-9 ay
öncesinden piyasa manipülasyonuna maruz kalıp kalmama durumu tahmin edilmiştir.
İlgili şirketlerin mali tablo ve nitel verileri elde edilerek sınıflandırma
için Yapay Sinir Ağları (ANN) ile Sınıflandırma ve Regresyon Ağacı (CART) yöntemleri kullanılmıştır. Tüm veri
seti ile doğrulama yöntemi olarak sadece 10 katlı çapraz doğrulama yöntemi
kullanıldığında CART karar ağacı genel tahmin doğruluğu %100, ANN ise % 94,12 olarak
elde edilmiştir. Veri seti %70 eğitim ve %30 test verisi olarak ikiye
ayrıldıktan sonra 10 katlı çapraz doğrulama yapıldığında Yapay Sinir Ağlarının genel
tahmin doğruluğu %86,67 iken CART’ın tahmin doğruluğu %80,00 olarak
bulunmuştur. Veri seti %70 eğitim ve %30 test seti olarak ikiye ayrılarak 10
katlı çapraz doğrulama yöntemi kullanıldığında ANN modeli CART karar ağacı
modeline göre daha yüksek tahmin performansı göstermiştir.
ART AND COMMUNICATION AS A NOVEL EXPERIENCE IN MODERN CULTURE
Authors: THEOLOGOU KOSTAS , RAPTI YOULI , FETTNER PETER , PAPAIOANNOU YOULI 
Published: June 2020

In this paper we discuss the deadlocks of defining art in modern culture. The lack of criteria and modernism revisited are of crucial issue in this account. The theoretical mainframe of our approach is founded on the Frankfurt School thinkers (Max Horkheimer, Theodor Adorno, Walter Benjamin), and of course Jürgen Habermas. This theoretical apparatus also draws on contemporary accounts given by Sorbonne Professor Marc Jimenez and art critic John A. Walker.[1] The paper discusses whether fine art may survive, in what forms – and to what purpose – in an age of mass media and in conditions of rapid networked communication. The paper sets off from the critical role radical art plays in today’s divided yet global world and on the continuing debates between high art and low culture, but reflects on the interaction between art, media and technology.
To support our argument we suggest Body Art and other web/digital and technological applications in art, and the cyber-art currently being produced for the internet. The paper acknowledges the numerous interactions between art and culture in a postmodern pluralistic world, and draws from the vast range of contemporary works of art to illustrate and to criticize theoretical points. The true test of theory in aesthetics is their application to particular cases. When a theory shows limitations in such an application, we gain clues as to what theoretical adjustments or innovations are called for to accommodate today’s works.
The introductory part of the essay comprehensively surveys recent debates on works of art, mass culture and society, and their socio-philosophical significance. The main discussion refers to the work of Walter Benjamin and Jürgen Habermas, aptly commented on by Marc Jimenez;[2] after exploring the complex relationships between culture and art as it’s reflected in that work, the argument provides an account of the 1980s political turn in aesthetics and explicates the impact of new communication technologies in modern culture. The narration is enhanced by specific examples of works of art in the era of mass media, web and digital culture, and underlines both the styles’ pluralism and the variety of parameters affecting the interaction between art and mass media communication. Critical findings and suggestions for further research conclude the paper.

[1] Marc Jimenez, Qu’est-ce que l’esthétique, Paris: Gallimard, 1997; John A. Walker, Art in the Age of Mass Media, London: Pluto, 2001.
[2] Jimenez, Ibid.
Les exploitations d’élevage herbivore dans l’Union européenne
Authors: CHATELLIER V. , COLSON F. , FUENTES M. , VARD T. 
Published: June 2020

Pour mieux appréhender la diversité des exploitations européennes d’élevage herbivore et pour affiner l’analyse des effets différenciés de changements de la Politique agricole commune (PAC) sur les exploitations laitières, allaitantes et ovines, la Direction Générale de l’Agriculture de la Commission européenne (1) a souhaité que soit élaborée, sur la base des données du Réseau d’Information Comptable Agricole (RICA), une méthode de classification complémentaire à celle privilégiant les orientations technico-économiques (OTEX). Cette typologie intitulée GLS, pour Grazing Livestock System, conduit à répartir, de façon homogène entre les Etats membres, les 1,6 millions d’exploitations européennes détenant plus d’une Unité de Gros Bétail (UGB) herbivore en quatre types de production, neuf systèmes d’élevage et dix-huit systèmes techniques. L’analyse des caractéristiques des exploitations selon cette typologie permet de rendre compte de la complexité des combinaisons productives, de la très forte hétérogénéité de structures d’exploitation entre Etats membres (en termes notamment de dimension économique, de spécialisation et d’intensification), de la forte contribution des exploitations laitières à l’offre de viande et du poids déterminant des aides directes dans la formation du revenu des éleveurs.
(1) Cette étude n’engage que la responsabilité de ses auteurs.
Traçabilité individuelle des viandes bovines à l’aide de marqueurs génétiques
Authors: SANCRISTOBAL-GAUD M. , RENAND G. , AMIGUES Y. , BOSCHER M.Y. , LEVEZIEL H. , BIBE B. 
Published: June 2020

En réponse à la crise de confiance des consommateurs et leur régulière désaffection pour la viande bovine, et dans le cadre des efforts développés actuellement pour améliorer et sécuriser la traçabilité des bovins, nous avions pour objectif de proposer et de valider une méthode d’identification individuelle des viandes bovines à l’aide de marqueurs moléculaires de type microsatellite. Plusieurs prélèvements ont été effectués sur des jeunes bovins de domaines expérimentaux INRA, in vivo et post mortem. La détermination des génotypes aux 11 loci, puis la comparaison deux à deux de ces génotypes à l’aide d’une méthode statistique adéquate prenant en compte les particularités des microsatellites permet de recommander d’une part que le typage soit réalisé sur au moins huit marqueurs pour assurer une traçabilité parfaite, et d’autre part que des précautions indispensables soient prises concernant la qualité des prélèvements et la gestion des échantillons lors d’une mise en œuvre à grande échelle.
Impact of the Voluntary Safety Standard for Liquid Laundry Packets on Child Injuries Treated in US Hospital Emergency Departments, 2012−2018
Authors: Hanway Stephen J. , Rodgers Gregory B. 
Published: June 2020

Objectives. To evaluate the effect of the voluntary safety standard for liquid laundry packets on the rate of injury involving children younger than 5 years in the United States. Methods. Semiannual national estimates of child injuries involving liquid laundry packets treated in US hospital emergency departments were developed for the July 2012 through December 2018 study period. We used a negative binomial regression model to estimate the effect of the voluntary standard on the injury rate following the standard’s publication at the end of 2015. The analysis controlled for the rapid growth of laundry packet use during the study period. Results are presented as relative risks and percentage changes in the injury rate. Results. The voluntary standard was associated with a 49.4% to 61.6% reduction in the rate of child injury. Conclusions. The results suggest that the requirements of the voluntary standard have effectively reduced the rate of child injury involving liquid laundry packets and may have prevented 9200 to 23 000 emergency department–treated injuries during the study period.