bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems
Authors: Wawrzczak-Bargieła Agnieszka , Ziółkowska Barbara , Piotrowska Anna , Starnowska-Sokół Joanna , Rojewska Ewelina , Mika Joanna , Przewłocka Barbara , Przewłocki Ryszard 
Published: February 2020

AbstractDisturbances in the function of the mesostriatal dopamine system may contribute to the development and maintenance of chronic pain, including its sensory and emotional/cognitive aspects. In the present study, we assessed the influence of chronic constriction injury (CCI) of the sciatic nerve on the expression of genes coding for dopamine and opioid receptors as well as opioid propeptides in the mouse mesostriatal system, particularly in the nucleus accumbens. We demonstrated bilateral increases in mRNA levels of the dopamine D1 and D2 receptors (the latter accompanied by elevated protein level), opioid propeptides proenkephalin and prodynorphin, as well as delta and kappa (but not mu) opioid receptors in the nucleus accumbens at 7 to 14 days after CCI. These results show that CCI-induced neuropathic pain is accompanied by a major transcriptional dysregulation of molecules involved in dopaminergic and opioidergic signaling in the striatum/nucleus accumbens. Possible functional consequences of these changes include opposite effects of upregulated enkephalin/delta opioid receptor signaling vs. dynorphin/kappa opioid receptor signaling, with the former most likely having an analgesic effect and the latter exacerbating pain and contributing to pain-related negative emotional states.
A brittleness evaluation method based on breaking energy theory for tight reservoir in Dagang Oilfield
Authors: Zhao Yudong , Gou Xiaoting 
Published: February 2020

AbstractThe tight reservoirs in Dagang Oilfield are deep in burial depth and complex in lithology, and the brittleness evaluation methods commonly used at home and abroad are not accurate enough to effectively guide the design of fracturing. As a result, the fracturing in the early days was low in success rate and not ideal in effect. In this study, from the perspective of breaking energy theory, based on a large number of core experiments, the factors affecting rock failure morphology have been analysed by using the breaking energy theory, and a brittleness evaluation method more suitable for the physical properties of tight reservoirs in Dagang Oilfield has been worked out. The results show that the main parameters affecting brittleness of tight reservoirs in Dagang Oilfield are Young’s modulus, dilatancy angle and peak strain. The correlation coefficient between the brittle index from the new method based on breaking energy theory and rock failure complexity increases to 0.789 compared with 0.329 of the brittle index from Rickman’s evaluation method. The new method solves the problem that previous brittleness index models at home and abroad are not suitable for tight reservoirs in Dagang Oilfield, and provides a theoretical basis for evaluating the fracability of tight reservoirs and improving fracturing effect in Dagang Oilfield.
The challenge of monoculturalism: what books are educators sharing with children and what messages do they send?
Authors: Adam Helen , Barratt-Pugh Caroline 
Published: February 2020

AbstractThe importance of recognising, valuing and respecting a child’s family, culture, language and values is increasingly articulated in educational policy. Diversity and inclusion are central themes of the guiding principles of early childhood education and care in Australia. Children’s literature can be a powerful tool for extending children’s knowledge and understandings of themselves and others who may be different culturally, socially or historically. However, evidence suggests many settings provide monocultural book collections which are counterproductive to principles of diversity. This paper reports on a larger study investigating factors and relationships influencing the use of children’s literature to support principles of cultural diversity in the kindergarten rooms of long day care centres. The study was conducted within an ontological perspective of constructivism and an epistemological perspective of interpretivism informed by sociocultural theory. A mixed methods approach was adopted and convergent design was employed to interpret significant relationships and their meanings. Twenty-four educators and 110 children from four long day care centres in Western Australia participated. Data were collected through semi-structured interviews, video-based observations, field notes, document analysis and a book audit. This study identified that current book collections in these four kindergarten rooms of long day care centres promote monocultural viewpoints and ‘othering’ of minority groups through limited access to books portraying inclusive and authentic cultural diversity. These findings have important social justice implications. The outcomes of this study have implications for educators, policy makers, early childhood organisations and those providing higher education and training for early childhood educators.
Knowledge, skills and beetles: respecting the privacy of private experiences in medical education
Authors: Veen Mario , Skelton John , De la Croix Anne 
Published: February 2020

In medical education, we assess knowledge, skills, and a third category usually called values or attitudes. While knowledge and skills can be assessed, this third category consists of ‘beetles’, after the philosopher Wittgenstein’s beetle-in-a-box analogy. The analogy demonstrates that private experiences such as pain and hunger are inaccessible to the public, and that we cannot know whether we all experience them in the same way. In this paper, we claim that unlike knowledge and skills, private experiences of medical learners cannot be objectively measured, assessed, or directly accessed in any way. If we try to do this anyway, we risk reducing them to knowledge and skills—thereby making curriculum design choices based on what can be measured rather than what is valuable education, and rewarding zombie-like student behaviour rather than authentic development. We conclude that we should no longer use the model of representation to assess attitudes, emotions, empathy, and other beetles. This amounts to, first of all, shutting the door on objective assessment and investing in professional subjective assessment. Second, changing the way we define ‘fuzzy concepts’ in medical education, and stimulating conversations about ambiguous terms. Third, we should reframe the way we think of competences and realize only part of professional development lies within our control. Most importantly, we should stop attempting to measure the unmeasurable, as it might have negative consequences.
Therapeutic Drug Monitoring of Antifungal Drugs: Another Tool to Improve Patient Outcome?
Authors: Vena Antonio , Muñoz Patricia , Mateos Miriam , Guinea Jesus , Galar Alicia , Pea Federico , Alvarez-Uria Ana , Escribano Pilar , Bouza Emilio 
Published: February 2020

Abstract
Introduction
This study aimed to examine the relationship among adequate dose, serum concentration and clinical outcome in a non-selected group of hospitalized patients receiving antifungals.

Methods
Prospective cross-sectional study performed between March 2015 and June 2015. Dosage of antifungals was considered adequate according to the IDSA guidelines, whereas trough serum concentrations (determined with HPLC) were considered adequate as follows: fluconazole > 11 µg/ml, echinocandins > 1 µg/ml, voriconazole 1–5.5 µg/ml and posaconazole > 0.7 µg/ml.

Results
During the study period, 84 patients (65.4% male, 59.6 years) received antifungals for prophylaxis (40.4%), targeted (31.0%) and empirical therapy (28.6%). The most frequent drug was micafungin (28/84; 33.3%) followed by fluconazole (23/84; 27.4%), voriconazole (15/84; 17.9%), anidulafungin (8/84; 9.5%), posaconazole (7/84; 8.3%) and caspofungin (3/84; 3.6%). Considerable interindividual variability was observed for all antifungals with a large proportion of the patients (64.3%) not attaining adequate trough serum concentrations, despite receiving an adequate antifungal dose. Attaining the on-target serum antifungal level was significantly associated with a favorable clinical outcome (OR = 0.02; 95% CI 0.01–0.64; p = 0.03), whereas the administration of an adequate antifungal dosage was not.

Conclusions
With the standard antifungal dosage, a considerable proportion of patients have low drug concentrations, which are associated with poor clinical outcome.
Molten salt synthesis, formation mechanism, and oxidation behavior of nanocrystalline HfB2 powders
Authors: Liu Da , Fu Qiangang , Chu Yanhui 
Published: February 2020

AbstractNanocrystalline HfB2 powders were successfully synthesized by molten salt synthesis technique at 1373 K using B and HfO2 as precursors within KCl/NaCl molten salts. The results showed that the as-synthesized powders exhibited an irregular polyhedral morphology with the average particle size of 155 nm and possessed a single-crystalline structure. From a fundamental aspect, we demonstrated the molten-salt assisted formation mechanism that the molten salts could accelerate the diffusion rate of the reactants and improve the chemical reaction rate of the reactants in the system to induce the synthesis of the high-purity nanocrystalline powders. Thermogravimetric analysis showed that the oxidation of the as-synthesized HfB2 powders at 773–1073 K in air was the weight gain process and the corresponding oxidation behavior followed parabolic kinetics governed by the diffusion of oxygen in the oxide layer.
Mn-Co-Ni-O thin films prepared by sputtering with alloy target
Authors: Li Ruifeng , Fu Qiuyun , Zou Xiaohua , Zheng Zhiping , Luo Wei , Yan Liang 
Published: February 2020

AbstractThe thin film of heat-sensitive materials has been widely concerned with the current trend of miniaturization and integration of sensors. In this work, Mn1.56Co0.96Ni0.48O4 (MCNO) thin films were prepared on SiO2/Si substrates by sputtering with Mn–Co–Ni alloy target and then annealing in air at different temperatures (650–900 °C). The X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM) analysis indicated that the main crystalline phase of MCNO thin films was spinel crystal structure; the surface of the thin films was very dense and uniform. The electrical properties of the thin films were studied in the temperature range of–5–50 °C. The MCNO thin film with a low room temperature resistance R25 of 71.1 kΩ and a high thermosensitive constant B value of 3305 K was obtained at 750 °C. X-ray photoelectron spectroscopy (XPS) analysis showed that the concentration of Mn3+ and Mn4+ cations in MCNO thin films is the highest when annealing temperature is 750 °C. The complex impedance analysis revealed internal conduction mechanism of the MCNO thin film and the resistance of the thin film was dominated by grain boundary resistance.
Electrical properties and luminescence properties of 0.96(K0.48Na0.52)(Nb0.95Sb0.05)–0.04Bi0.5(Na0.82K0.18)0.5ZrO3-xSm lead-free ceramics
Authors: Li Wei , Hao Jigong , Li Wei , Du Juan , Fu Peng , Sun Wenzhi , Chen Chong , Xu Zhijun , Chu Ruiqing 
Published: February 2020

AbstractIn this paper, Sm-doped 0.96(K0.48Na0.52)(Nb0.95Sb0.05)–0.04Bi0.5(Na0.82K0.18)0.5ZrO3(abbreviated as KNSN–0.04BNKZ) lead-free piezoelectric ceramics were prepared by conventional solid-state sintering method and the effects of Sm2O3on the phase structure, microstructure, electrical and luminescent properties of KNSN–0.04BNKZ potteries were studied. Results revealed that a single solid solution phase with pseudo-cubic perovskite structure was formed between KNSN–0.04BNKZ and Sm2O3. Existence of weak dielectric/ferroelectric properties with a diffuse dielectric anomaly and slimP–Ehysteresis loops of the Sm-doped KNSN–0.04BNKZ demonstrated the ferroelectric relaxor behavior of the KNNS–0.04BNKZ–xSm ceramics. Accordingly, the temperature stability and fatigue behavior of the modified ceramics were significantly improved. It was found that the KNSN–0.04BNKZ ceramics with 0.002 mol Sm addition exhibited nearly temperature independent properties and fatigue-free behavior. Moreover, Sm-modified KNSN–0.04BNKZ exhibits a bright photoluminescence with a strong orange emission under visible light irradiation. As a material with both electrical and luminescent properties, it has good application prospect in future optoelectronic components by integrating its luminescent and electrical properties.
The impact of food-related behaviours and emotional functioning on body mass index in an adult sample
Authors: Czepczor-Bernat Kamila , Brytek-Matera Anna 
Published: February 2020

Abstract
Purpose
The aim of this study was to evaluate the impact of food-related behaviours (emotional eating, snacking) and emotional functioning (negative emotions, stress, emotional dysregulation) on body mass index in an adult sample. Direct and indirect relationships of the above-mentioned variables were examined.

Methods
The total sample comprised 298 adults. All participants completed the Difficulties in Emotion Regulation Scale, the Positive and Negative Affect Schedule, the Feeling of Stress Questionnaire and the Three-Factor Eating Questionnaire.

Results
Our findings showed that food-related behaviours and emotional functioning are related to body mass index in adults. In addition, emotional dysregulation and negative emotions did not have direct impact on snacking. Moreover, snacking did not have a direct impact on body mass index. However, snacking had an indirect effect on body mass index (through emotional eating). The other relationships were significant and consistent with the hypothesised positive direction.

Conclusion
We found significant relationships among (almost all) food-related behaviours, emotional functioning and body mass index in adults. However, future research on pathways from negative emotions/emotional dysregulation to snacking and from snacking to BMI should be conducted.

Level of evidence
Level V, descriptive study.
Atmospheric disturbance on the gas explosion in closed fire zone
Authors: Duan Yulong , Wang Shuo , Wang Wenhe , Zheng Kai 
Published: February 2020

AbstractIn order to avoid serious safety accidents caused by closed fire zone, based on the continuous monitoring of atmospheric pressure at different monitoring points in multiple mines, the atmospheric pressure fluctuation model and the air leakage model were established and analyzed. The change law with time of oxygen concentration and gas concentration in the fire zone were obtained due to atmospheric disturbances under the influence of different pressure difference, volume and size of fire area, wind resistance, gas emission, sealing moments, etc. so as to evaluate the explosion risk of a closed fire zone. Research showed that the mine atmosphere fluctuates with the atmosphere of ground, and the pressure difference between the inner and outer sides of the enclosed fire zone is affected by the periodic fluctuation of atmosphere, which has about 16-h cosine fluctuation and approximate 8-h fixed value. Compared with the fire zone with poor sealing quality, good sealing fire zone has better resistance to atmospheric disturbance. The reduction of oxygen concentration in the inner side of a well-sealed fire zone mainly depends on the dilution of methane, which is more likely to accumulate and rise rapidly. And the fire zone with poor sealing quality is easy to be interfered. The inner oxygen concentration and gas concentration are easily affected by the absolute gas emission and the air leakage in the fire zone. Fire zone with small wind resistance and small volume is especially obvious. At the initial stage of the closed fire zone it's very possible to happen explosion. The time duration of explosion danger varies under different conditions, and the atmospheric disturbance may lead to repeated explosions in some cases. It's suggested to take some methods to avoid explosions according to the real-time situation, closure time, oxygen concentration and gas concentration of fire zone.
CO2 and SO2 emission characteristics of the whole process industry chain of coal processing and utilization in China
Authors: Zhu Tao , Wang Ruonan , Yi Nengjing , Niu Wenfeng , Wang Lifeng , Xue Zeyu 
Published: February 2020

AbstractThe total coal consumption in China is on the rise. The characteristics of CO2 and SO2 emissions in the whole process of coal processing and utilization in China are worthy of study. Based on the five links of the whole process of coal production and utilization, including coal production, raw coal processing, logistics and transportation, conversion and utilization and resource utilization, this paper summarized and analyzed the energy consumption and pollutant emission sources of these five links, combined with the US Environmental Protection Agency’s AP-42 method and IPCC method, to calculate total pollutant discharge and emission factors, where the emission factors were corrected by conversion efficiency. At the same time, uncertainty analysis is performed about CO2 and SO2 emissions. The results showed that CO2 emissions were 3.657 billion tons, and emission reductions were 61 million tons, and SO2 emissions were 4,844,500 tons, and emission reductions were 10.3595 million tons in 2015.
Rationalitätsforderungen als konstitutive Normen
Authors: Zahn Jonas 
Published: February 2020

ZusammenfassungIn der zeitgenössischen metaethischen Literatur gibt es eine gängige Unterscheidung zwischen zwei Arten von Sollen: dem Sollen substanzieller normativer Gründe und dem Sollen struktureller Forderungen oder Prinzipien der Rationalität (I.). Diese Unterscheidung zwischen Gründesollen und rationalem Sollen führt zur Frage, wie beide zusammenhängen. Eine weit verbreitete Theorie behauptet, dass die Normativität des rationalen Sollens durch die Normativität des Gründesollens zu erklären ist (II.). Ich argumentiere dafür, dass keine Variante dieser Theorie des Primats normativer Gründe in der Lage ist, die Normativität des rationalen Sollens befriedigend zu erklären (III.). Aus meiner Kritik leite ich zwei Adäquatheitsbedingungen ab, die eine Theorie der Normativität der Rationalität einholen muss. Im letzten Teil skizziere ich eine alternative Theorie, deren grundlegender Gedanke ist, dass Rationalitätsforderungen als konstitutive Normen vernünftiger Aktivität zu verstehen sind. Wie ich zeigen werde, verspricht sie beide Adäquatheitsbedingungen einzuholen (IV.).
New methods of geothermal potential assessment in the Pannonian basin
Authors: Nádor Annamária , Sebess-Zilahi László , Rotár-Szalkai Ágnes , Gulyás Ágnes , Markovic Tamara 
Published: February 2020

AbstractThe Pannonian basin in Central Europe is well known for its rich geothermal resources. Although geothermal energy has been utilised, mainly for direct use purposes, for a long time, there are still a lot of untapped resources. This paper presents novel methods for outlining and assessing the theoretical and technical potential of partly still unknown geothermal reservoirs, based on a case study from the Dráva basin, one of the sub-basins of the Pannonian basin along the Hungarian–Croatian border. The presented methods include reservoir delineation based on combining geological bounding surfaces of the Upper Pannonian basin-fill units with a set of isotherms deriving from a conductive geothermal model. The geothermal potential of each identified reservoir was calculated by a Monte Carlo method, which was considered as being represented by the heat content of the fluids stored in the effective pore space (‘moveable fluid’). The results underline the great untapped geothermal potential of the Dráva basin, especially that of the reservoir storing thermal water of 50–75°C, which has the largest volume and the greatest stored heat content.
Maternal dietary patterns during pregnancy derived by reduced-rank regression and birth weight in the Chinese population
Authors: Liu Danmeng , Cheng Yue , Mi Baibing , Zeng Lingxia , Qu Pengfei , Li Shanshan , Zhang Ruo , Qi Qi , Wu Chenlu , Gao Xiangyu , Liu Yezhou , Dang Shaonong , Yan Hong 
Published: February 2020

AbstractFew studies have investigated the association between maternal dietary patterns (DP) during pregnancy, derived from reduced-rank regression (RRR), and fetal growth. This study aims to identify DP during pregnancy associated with macro- and micronutrient intakes, using the RRR method, and to examine their relationship with birth weight (BW). We used data of 7194 women from a large-scale cross-sectional survey in Northwest China. Dietary protein, carbohydrate, haem Fe density and the ratio of PUFA and MUFA:SFA were used as the intermediate variables in the RRR model to extract DP. Generalised estimating equation models were applied to evaluate the associations between DP and BW and related outcomes (including BW z-score, low birth weight (LBW) and small for gestational age (SGA)). Four DP during pregnancy were identified. Socio-demographically disadvantaged pregnant women were more likely to have lower BW and lower adherence to DP1 (high legumes, soyabean products, vegetables and animal-source foods, with relative low wheat and oils). Women with medium and high adherence to DP1 had significantly increased BW (medium 28·6 (95 % CI 7·1, 50·1); high 25·2 (95 % CI 2·7, 47·6)) and BW z-score and had significantly reduced risks of LBW and SGA. The associations were stronger among women with babies <3100 g. There is no association between other DP and outcomes. Higher adherence to the DP that was high in legumes, soyabean products, vegetables and animal-source foods was associated with improved BW in the Chinese pregnant women, particularly among those with disadvantageous socio-demographic conditions.