bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model
Authors: Shimizu Kampei , Kataoka Hiroharu , Imai Hirohiko , Yamamoto Yuto , Yamada Tomohiro , Miyata Haruka , Koseki Hirokazu , Abekura Yu , Oka Mieko , Kushamae Mika , Ono Isao , Miyamoto Susumu , Nakamura Masanori , Aoki Tomohiro 
Published: November 2020

Abstract
Past studies have elucidated the crucial role of macrophage-mediated inflammation in the growth of intracranial aneurysms (IAs), but the contributions of hemodynamics are unclear. Considering the size of the arteries, we induced de novo aneurysms at the bifurcations created by end-to-side anastomoses with the bilateral common carotid arteries in rats. Sequential morphological data of induced aneurysms were acquired by magnetic resonance angiography. Computational fluid dynamics analyses and macrophage imaging by ferumoxytol were performed. Using this model, we found that de novo saccular aneurysms with a median size of 3.2 mm were induced in 20/45 (44%) of animals. These aneurysms mimicked human IAs both in morphology and pathology. We detected the focal growth of induced aneurysms between the 10th and 17th day after the anastomosis. The regional maps of hemodynamic parameters demonstrated the area exposed to low wall shear stress (WSS) and high oscillatory shear index (OSI) colocalized with the regions of growth. WSS values were significantly lower in the growing regions than in ones without growth. Macrophage imaging showed colocalization of macrophage infiltration with the growing regions. This experimental model demonstrates the potential contribution of low WSS and high OSI to the macrophage-mediated growth of saccular aneurysms.
Intersexual differences in leaf size and shape in dioecious Adriana tomentosa
Authors: Rabska Mariola , Warwick Nigel W M , Iszkuło Grzegorz , Gross Caroline L 
Published: November 2020

Abstract

Aims
Leaf size and shape as objects of natural selection can play adaptive roles, and can change with the age of leaves. They can differ between sexes in dioecious species, and in most cases, females have larger leaves. Previous studies showed that sexes of Adriana tomentosa differed in their leaf lobing. In this study, we investigated whether there were other differences between sexes in leaf size, shape and ecophysiology, and if those differences were connected with adaptations and reproductive roles in the sexes of A. tomentosa.

Methods
Physical and chemical features of young and old leaves originating from female and male A. tomentosa plants growing in two disjunct populations in eastern Australia were measured. We determined leaf area, perimeter length, serration, circularity, aspect ratio (AR), roundness and the ecophysiological factors: specific leaf area, dry matter content, leaf moisture, relative water content, δ 13C, δ 15N isotope compositions, carbon and nitrogen contents and C:N ratio. Leaf lobing, the degree of lamina damage and the content of photosynthetic pigments were also determined.

Important Findings
In both populations studied, the sex of plants significantly influenced almost all parameters connected with leaf morphology such as area, perimeter length, circularity, AR and roundness. Contrary to expectations, males from both populations had a greater leaf area that was independent of leaf age. Male leaves were more lobed with a longer perimeter, but they were less elongated and less serrated. Only small differences between female and male leaves were observed for the ecophysiological factors. The degree of leaf damage differed between sexes but also with population. Differences between sexes in leaf area and shape were not compensated by measured ecophysiological factors. However, leaf area may be compensated by other ecophysiological mechanisms related to leaf morphology, because females had greater leaf serration in comparison to males despite the smaller leaf area.
Lifting propositional proof compression algorithms to first-order logic
Authors: Gorzny Jan , Postan Ezequiel , Woltzenlogel Paleo Bruno 
Published: November 2020

Abstract
Proofs are a key feature of modern propositional and first-order theorem provers. Proofs generated by such tools serve as explanations for unsatisfiability of statements. However, these explanations are complicated by proofs which are not necessarily as concise as possible. There are a wide variety of compression techniques for propositional resolution proofs but fewer compression techniques for first-order resolution proofs generated by automated theorem provers. This paper describes an approach to compressing first-order logic proofs based on lifting proof compression ideas used in propositional logic to first-order logic. The first approach lifted from propositional logic delays resolution with unit clauses, which are clauses that have a single literal. The second approach is partial regularization, which removes an inference $\eta $ when it is redundant in the sense that its pivot literal already occurs as the pivot of another inference in every path from $\eta $ to the root of the proof. This paper describes the generalization of the algorithms LowerUnits and RecyclePivotsWithIntersection (Fontaine et al.. Compression of propositional resolution proofs via partial regularization. In Automated Deduction—CADE-23—23rd International Conference on Automated Deduction, Wroclaw, Poland, July 31–August 5, 2011, p. 237--251. Springer, 2011) from propositional logic to first-order logic. The generalized algorithms compresses resolution proofs containing resolution and factoring inferences with unification. An empirical evaluation of these approaches is included.
Generalized anisotropic κ-cookbook: 2D fitting of Ulysses electron data
Authors: Scherer K , Husidic E , Lazar M , Fichtner H 
Published: November 2020

ABSTRACT
Observations in space plasmas reveal particle velocity distributions out of thermal equilibrium, with anisotropies (e.g. parallel drifts and/or different temperatures, T∥ – parallel and T⊥ – perpendicular, with respect to the background magnetic field), and multiple quasi-thermal and suprathermal populations with different properties. The recently introduced (isotropic) κ-cookbook is generalized in this paper to cover all these cases of anisotropic and multicomponent distributions reported by the observations. We derive general analytical expressions for the velocity moments and show that the common (bi-)Maxwellian and (bi-)κ-distributions are obtained as limiting cases of the generalized anisotropic κ-cookbook (or recipes). Based on this generalization, a new two-dimensional fitting procedure is introduced, with an improved level of confidence compared to the 1D fitting methods widely used to quantify the main properties of the observed distributions. The non-linear least-squares fit is applied to electron data sets measured by the Ulysses spacecraft confirming the existence of three different populations, a quasi-thermal core and two suprathermal (halo and strahl) components. In general, the best overall fit is given by the sum of a Maxwellian distribution and two generalized κ-distributions.
Quenching and morphological evolution due to circumgalactic gas expulsion in a simulated galaxy with a controlled assembly history
Authors: Davies Jonathan J , Crain Robert A , Pontzen Andrew 
Published: November 2020

ABSTRACT
We examine the influence of dark matter halo assembly on the evolution of a simulated ∼L⋆ galaxy. Starting from a zoom-in simulation of a star-forming galaxy evolved with the EAGLE galaxy formation model, we use the genetic modification technique to create a pair of complementary assembly histories: one in which the halo assembles later than in the unmodified case, and one in which it assembles earlier. Delayed assembly leads to the galaxy exhibiting a greater present-day star formation rate than its unmodified counterpart, while in the accelerated case the galaxy quenches at z ≃ 1, and becomes spheroidal. We simulate each assembly history nine times, adopting different seeds for the random number generator used by EAGLE’s stochastic subgrid implementations of star formation and feedback. The systematic changes driven by differences in assembly history are significantly stronger than the random scatter induced by this stochasticity. The sensitivity of ∼L⋆ galaxy evolution to dark matter halo assembly follows from the close coupling of the growth histories of the central black hole (BH) and the halo, such that earlier assembly fosters the formation of a more massive BH, and more efficient expulsion of circumgalactic gas. In response to this expulsion, the circumgalactic medium reconfigures at a lower density, extending its cooling time and thus inhibiting the replenishment of the interstellar medium. Our results indicate that halo assembly history significantly influences the evolution of ∼L⋆ central galaxies, and that the expulsion of circumgalactic gas is a crucial step in quenching them.
A suppressor tRNA-mediated feedforward loop eliminates leaky gene expression in bacteria
Authors: Ho Joanne M L , Miller Corwin A , Parks Sydney E , Mattia Jacob R , Bennett Matthew R 
Published: November 2020

Abstract
Ligand-inducible genetic systems are the mainstay of synthetic biology, allowing gene expression to be controlled by the presence of a small molecule. However, ‘leaky’ gene expression in the absence of inducer remains a persistent problem. We developed a leak dampener tool that drastically reduces the leak of inducible genetic systems while retaining signal in Escherichia coli. Our system relies on a coherent feedforward loop featuring a suppressor tRNA that enables conditional readthrough of silent non-sense mutations in a regulated gene, and this approach can be applied to any ligand-inducible transcription factor. We demonstrate proof-of-principle of our system with the lactate biosensor LldR and the arabinose biosensor AraC, which displayed a 70-fold and 630-fold change in output after induction of a fluorescence reporter, respectively, without any background subtraction. Application of the tool to an arabinose-inducible mutagenesis plasmid led to a 540-fold change in its output after induction, with leak decreasing to the level of background mutagenesis. This study provides a modular tool for reducing leak and improving the fold-induction within genetic circuits, demonstrated here using two types of biosensors relevant to cancer detection and genetic engineering.
Basic mechanisms and kinetics of pause-interspersed transcript elongation
Authors: Qian Jin , Dunlap David , Finzi Laura 
Published: November 2020

Abstract
RNA polymerase pausing during elongation is an important mechanism in the regulation of gene expression. Pausing along DNA templates is thought to be induced by distinct signals encoded in the nucleic acid sequence and halt elongation complexes to allow time for necessary co-transcriptional events. Pausing signals have been classified as those producing short-lived elemental, long-lived backtracked, or hairpin-stabilized pauses. In recent years, structural microbiology and single-molecule studies have significantly advanced our understanding of the paused states, but the dynamics of these states are still uncertain, although several models have been proposed to explain the experimentally observed pausing behaviors. This review summarizes present knowledge about the paused states, discusses key discrepancies among the kinetic models and their basic assumptions, and highlights the importance and challenges in constructing theoretical models that may further our biochemical understanding of transcriptional pausing.
The Zap-X Radiosurgical System in the Treatment of Intracranial Tumors: A Technical Case Report
Authors: Pan Longsheng , Qu Baolin , Bai Jingmin , Huang Lichao , Wang Jinyuan , Wang Chengcheng , Dai Xiangkun , Weidlich Georg , Adler John R 
Published: November 2020

Abstract

BACKGROUND AND IMPORTANCE
The Zap-X system (Zap Surgical Systems Inc, San Carlos, California) is a radically new surgical robot designed for brain and head and neck radiosurgery. It represents the first new dedicated brain stereotactic radiosurgery platform in almost half a century optimizing the goals of safety, speed, and accuracy. The Zap-X system was used in a required Chinese National Medical Products Administration clinical study. In early January 2020, 2 patients were treated with the Zap-X robot prior to a national COVID-19 lockdown. Both were closely followed via clinical exam and magnetic resonance imaging (MRI) imaging. Prospectively collected data were used to generate this report.

CLINICAL PRESENTATION
Two female patients, each harboring either a trigeminal schwannoma or petroclival meningioma, were treated with the Zap-X robot. Respective tumor volumes were 2.60 and 4.02 cm3. A radiation dose of 13 Gy was prescribed to the 50% isodose line. At 8 mo of follow-up, preoperative symptoms were either resolved or stable and MRI imaging demonstrated a 31% and 56% reduction in lesion volume, respectively. In both patients, symptoms improved, and tumor volumes decreased, whereas no major complication was observed.

CONCLUSION
Given only 2 patients and short-term follow-up, any conclusions about the safety and efficacy of the Zap-X radiosurgery robot are preliminary. However, in the absence of any other published outcomes to date, this small case series may be of interest to many radiosurgical specialists.
Comparison of treatment retention and response to secukinumab versus tumour necrosis factor inhibitors in psoriatic arthritis
Authors: Lindström Ulf , Glintborg Bente , Di Giuseppe Daniela , Schjødt Jørgensen Tanja , Gudbjornsson Bjorn , Lederballe Grøn Kathrine , Aarrestad Provan Sella , Michelsen Brigitte , Lund Hetland Merete , Wallman Johan K , Nordström Dan , Trokovic Nina , Love Thorvardur Jon , Krogh Niels Steen , Askling Johan , Jacobsson Lennart T H , Kristensen Lars Erik 
Published: November 2020

Abstract

Objectives
To compare treatment retention and response to secukinumab vs adalimumab, including the other four TNF inhibitors (TNFi) as comparators, in PsA.

Methods
All patients with PsA starting secukinumab or a TNFi in 2015–2018 were identified in the biologic registers of the Nordic countries. Data on comorbidities were linked from national registers. One-year treatment retention and hazard ratios (HRs) for treatment discontinuation were calculated. The proportion achieving a 6 month 28-joint Disease Activity Index for Psoriatic Arthritis (DAPSA28) remission was determined together with odds ratios (ORs) for remission (logistic regression). Both HRs and ORs were calculated with adalimumab as the reference and adjusted for baseline characteristics and concurrent comorbidities. All analyses were stratified by the line of biologic treatment (first, second, third+).

Results
We identified 6143 patients contributing 8307 treatment courses (secukinumab, 1227; adalimumab, 1367). Secukinumab was rarely used as the first biologic, otherwise baseline characteristics were similar. No clinically significant differences in treatment retention or response rates were observed for secukinumab vs adalimumab. The adjusted HRs for discontinuation per the first, second and third line of treatment were 0.98 (95% CI 0.68, 1.41), 0.94 (0.70, 1.26) and 1.07 (0.84, 1.36), respectively. The ORs for DAPSA28 remission in the first, second and third line of treatment were 0.62 (95% CI 0.30, 1.28), 0.85 (0.41, 1.78) and 0.74 (0.36, 1.51), respectively. In the subset of patients previously failing a TNFi due to ineffectiveness, the results were similar.

Conclusion
No significant differences in treatment retention or response were observed between secukinumab and adalimumab, regardless of the line of treatment. This suggests that even in patients who have failed a TNFi, choosing either another TNFi or secukinumab may be equally effective.
Effect of adalimumab on axial manifestations in Japanese patients with psoriatic arthritis: a 24 week prospective, observational study
Authors: Makino Takamitsu , Ihn Hironobu , Nakagawa Motoo , Urano Misugi , Okuyama Ryuhei , Katoh Norito , Tateishi Chiharu , Masuda Koji , Ogawa Eisaku , Nishida Emi , Nishimoto Shohei , Muramoto Kenzo , Tsuruta Daisuke , Morita Akimichi 
Published: November 2020

Abstract

Objectives
PsA is characterized by enthesitis, synovitis and osseous involvement in the peripheral and axial joints. Few studies have examined axial involvement in PsA using imaging techniques. Here we examined axial involvement in PsA patients using MRI. In addition, we determined the efficacy of 24 week adalimumab treatment in improving the MRI findings of spondylitis and sacroiliitis.

Methods
This was a prospective, open-label, single-arm study in patients with PsA. Adalimumab was administered to patients for a total of 24 weeks. MRI examinations were conducted at baseline and at week 24 of adalimumab treatment.

Results
Thirty-seven patients with PsA were included in this study. Spondylitis was observed in at least one site of the positive scan in 91% (n = 31) of patients with PsA. The number of arthritic sites in the cervical, thoracic and lumbar regions of the spine was 48, 67 and 53, respectively. All patients had MRI-determined sacroiliitis of grade ≥1 severity while 28 patients (82%) had grade ≥2 sacroiliitis in at least one sacroiliac region. Sacroiliac arthritis was statistically more severe on the right side than on the left side (P &lt; 0.05). In 34 patients with PsA, the thoracic spine was the most common site of spondylitis. In addition, 24 week adalimumab treatment led to an improvement in the mean number of spondylitis sites and the mean grade of sacroiliitis.

Conclusion
Treatment with adalimumab for 24 weeks resulted in improvement in spondylitis and sacroiliitis.
Rare immunofluorescence patterns of autoantibodies on HEp-2 cells defined by ICAP identify different autoimmune diseases in the absence of associated specificities: a Spanish multicentre study
Authors: Irure-Ventura Juan , Rodríguez Carmen , Vergara-Prieto Esther , Vargas Maria Luisa , Quirant Bibiana , Jurado Aurora , Fernández-Pereira Luis , Martínez-Cáceres Eva , San José Miriam , López-Hoyos Marcos ,   the GEAI and EASI groups
Published: November 2020

Abstract

Objectives
ANA are the most extensively used test for the diagnosis of systemic autoimmune diseases. However, testing by indirect immunofluorescence assays (IIFAs) on HEp-2 cells, the gold standard test, is time-consuming and needs expertise. Thus there is a trend to replace it with other automated solid-phase assays directed against specific ANA. Nonetheless, the Hep-2 cell is an autoantigen array and ANA have been classified into 29 types, some of them with no clear association with a specificity to be detected. It is especially in these uncommon patterns where no clinical relationship is found and no antigenic specificity is detected. Here we retrospectively collected clinical data from patients with confirmed uncommon HEp-2 IIFA patterns to search for an associated clinical condition.

Methods
We conducted an observational retrospective study including 608 patients with organ-specific and non-organ-specific autoimmune diseases (OSADs and NOSADs, respectively) with a confirmed rare pattern of ANA detected by IIFA on HEp-2 cells in the routine practice of the Spanish European Autoantibodies Standardization Initiative laboratories. Inclusion criteria are the existence of a minimum follow-up of 2 years and the availability of clinical data.

Results
Nuclear patterns were more frequent in SLE (P = 0.001) and SS (P = 0.001), whereas the cytoplasmic ones were significantly higher in SSc (P = 0.022) and inflammatory myositis (P = 0.016). Mitotic patterns did not show any preferences for a specific disease and 62.7% of them corresponded to the nuclear mitotic apparatus pattern (AC-26). The most frequent NOSADs in patients with the AC-26 pattern were SLE (28.6%), SS (11.9%) and RA (11.9%). The cytoplasmic HEp-2 IIFA patterns were equally distributed in both groups of patients. In the OSAD patients there was no predominant pattern, except for AC-6 in primary biliary cholangitis due to Sp-100 antibodies (P &lt; 0.001).

Conclusion
Detection of infrequent ANA might be a unique finding with no disease-associated specificities and could lead to the suspicion of an autoimmune disease.
Syndemics & syndemogenesis in COVID-19 and rheumatic and musculoskeletal diseases: old challenges, new era
Authors: Nikiphorou Elena , Alpizar-Rodriguez Deshire , Gastelum-Strozzi Alfonso , Buch Maya , Peláez-Ballestas Ingris 
Published: November 2020

Abstract
People with rheumatic and musculoskeletal diseases (RMDs) are facing several challenges during the COVID-19 pandemic, such as poor access to regular health services and drug shortages, particularly in developing countries. COVID-19 represents a syndemic, synergistic condition that interacts with and exacerbates pre-existing diseases such as RMDs, other co-morbidities and social conditions. The emerging evidence on both biological and non-biological factors implicated in worse outcomes in people with RMDs affected by the COVID-19 pandemic, whether infected by the virus or not, calls for the need to use more novel and holistic frameworks for studying disease. In this context, the use of a syndemic framework becomes particularly relevant. We appeal for a focus on the identification of barriers and facilitators to optimal care of RMDs in the context of the COVID-19 pandemic, in order to tackle both the pandemic itself and the health inequities inherent to it.
A systematic review of implicit attitudes and their neural correlates in eating behaviour
Authors: Gallucci Alessia , Del Mauro Lilia , Pisoni Alberto , Lauro Leonor J Romero , Mattavelli Giulia 
Published: November 2020

AbstractAn increasing number of studies suggest that implicit attitudes towards food and body shape predict eating behaviour and characterize patients with eating disorders (EDs). However, literature has not been previously analysed; thus, differences between patients with EDs and healthy controls and the level of automaticity of the processes involved in implicit attitudes are still matters of debate. The present systematic review aimed to synthesize current evidence from papers investigating implicit attitudes towards food and body in healthy and ED populations. PubMed, EMBASE (Ovid), PsycINFO, Web of Science and Scopus were systematically screened and 183 studies using different indirect paradigms were included in the qualitative analysis. The majority of studies reported negative attitudes towards overweight/obese body images in healthy and ED samples and weight bias as a diffuse stereotypical evaluation. Implicit food attitudes are consistently reported as valid predictors of eating behaviour. Few studies on the neurobiological correlates showed neurostimulation effects on implicit attitudes, but how the brain automatically processes implicit evaluations remains an open area of research. In conclusion, implicit attitudes are relevant measures of eating behaviour in healthy and clinical settings, although evidence about their neural correlates is limited.