bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Safety and Therapeutic Effect Analysis of Intraoperative Intraperitoneal Chemotherapy with Lobaplatin for Hepato-Biliary-Pancreatic Cancer
Authors: Chen Gang , Chen Hao , Zhang Qifan , Zhang Siyun , Li Huanyu , Tan Qing , Zhou Jie , Zhu Bili , Wang Kai 
Published: April 2020

Abstract
Background

To examine the safeness and efficacy of intraoperative intraperitoneal perfusion chemotherapy with lobaplatin on hepato-biliary-pancreatic cancer.
Methods

Clinical data were retrospectively collected from a total of 66 patients with HBP cancer undertaken surgeries. They were divided into two groups: the study (lobaplatin) group (33 patients) and the control group (33 patients). The disease-free survival rate, postoperative complications, and chemotherapy side effects (bone marrow, liver, and kidney toxicity) were analyzed to examine the safeness and efficacy of intraoperative intraperitoneal chemotherapy with lobaplatin.
Results

In the study group, two patients had a postoperative subphrenic infection and increased peritoneal effusion, one patient had postoperative leukopenia and thrombocytopenia, while the control group had postoperative abnormal coagulation function in 1 patient, and gastrointestinal bleeding in 1 patient, no significant difference in postoperative complication was observed between the two groups. There was no significant difference in the liver and kidney function between the two groups after surgery (p > 0.05). A total of 26 patients in the two groups had recurrence or metastasis within one year after surgery, including eight patients in the study group and 18 patients in the control group. The recurrence rate of hepatocellular cancer in the lobaplatin group and control was 21.14% and 60%, respectively (P = 0.012 < 0.05). But there was no significant difference in the disease-free survival function analysis (P = 0.127 > 0.05).
Conclusions

Intraperitoneal perfusion chemotherapy with lobaplatin is a safe and effective treatment in the process of radical resection of hepato-biliary-pancreatic tumors, which has therapeutic potential in reducing postoperative tumor recurrence and metastasis.
The effect of extracellular matrix on myogenic induction of adipose mesenchymal stem cells
Authors: Fei Wenyong , xie bin , Liu Ying , Liu Mingsheng , Wang Xuanqi , Zhang Yao , Cao Shichao , Wang Jingcheng , Yan Lianqi , Pei Ming 
Published: April 2020

Abstract
Bankground: As one of the hot cells in the field of regenerative medicine, adipose mesenchymal stem cells(ADSCs) have been proved to have the ability of myoblast differentiation, but the disadvantage is that the efficiency of myoblast differentiation is not very high.Extracellular matrix(ECM), as a mixture of cytokines and proteins secreted by cells, is the substance secreted by cells. It has the advantages of non-toxic and harmless, and can provide the necessary material and environmental basis for cell growth and development.This study was to explore whether the myogenic differentiation potential of ADSCs cultured in ECM was improved.Method: ADSCs were extracted from subcutaneous fat of male SD rats at the age of 3 months and weight 250g. The third generation cellular of ADSCs were prepared for ECM，and the ECM was contained in the culture bottle for amplify the ADSCs. Myogenic induction was performed by 5-azacytidine using the same generation of ADSCs cultured with ECM and non-ECM.Result: ECM can significantly increase the rate of cell proliferation (P<0.05).Immunofluorescence detected the expression of β-actin, Myod and Desmin in cells ,and showed no significant difference in the expression of β-actin between groups (P>0.05). However, there were significant differences in Myod and Desmin between groups (P<0.001).RT-PCR showed that the mRNA expressions of myosin heavy chain(MHC), troponin, Myogein and Myf5 were significantly different among groups (P<0.001).Conclusion: ECM culture of ADSCs can improve its growth rate and myogenic differentiation potential.
Application of Electrospinning to SiC Fiber Synthesis
Authors: Hu Shao-Hwa , Dai Hang , Wu Li-Chun , Ai Ya-Zhao 
Published: April 2020

Abstract
Silicon carbide (SiC) possesses unique properties and is widely applied in household and military uses. This study explored the manufacturing process of SiC fibers. In the experiment, polycarbosilane (PCS) was dissolved in a mixed solvent of C8H10 and dimethylformamide (DMF) to form a solution, and electrospinning was employed to synthesize PCS fibers. PCS fibers underwent a curing process and a 2-h calcination at 1200°C in N2 atmosphere to convert PCS fibers into β-SiC fibers. The solute recruitment, solvent mixing ratio, and voltage in the experiment were defined as process parameters through which to examine the influence each parameter had on electrospinning. The PCS fibers were discovered to exhibit the most even size under the following condition: PCS recruitment of 1.0 g/ml, DMF constituting 30% of the solvent volume, voltage of 25 kV, spraying speed of 1.0 ml/h, and spinning distance of 15 cm. Under electron microscopy, the diameter of each PCS fiber was determined to be 1.0 μm, and the diameter of each β-SiC fiber was 0.8 μm.
Loop Based Design and Classification of Planar Scissor Linkages
Authors: Kiper Gökhan , Korkmaz Koray , Gür Şebnem , Müjde  , Maden Feray , Akgün Yenal , Karagöz Cevahir 
Published: April 2020

Abstract
Scissor linkages have been used for several applications since ancient Greeks and Romans. In addition to simple scissor linkages with straight rods, linkages with angulated elements were introduced in the last decades. In the related literature, two methods seem to be used to design scissor linkages, one of which is based on scissor elements, and the other is based on assembling loops. This study presents a systematic classification of scissor linkages as assemblies of rhombus, kite, dart, parallelogram and anti-parallelogram loops using frieze patterns and long-short diagonal connections. After the loops are multiplied along a curve as a pattern, the linkages are obtained by selection of proper common link sections for adjacent loops. The resulting linkages are analyzed for their motion and they are classified as realizing scaling deployable, angular deployable or transformable motion. Some of the linkages obtained are novel. Totally 10 scalable deployable, 1 angular deployable and 8 transformable scissor linkages are listed. Designers in architecture and engineering can use this list of linkages as a library of scissor linkage topologies.
Evaluation of temporal drought variation and projection in a tropical river basin of Kerala
Authors: Jincy Rose M. A. , Chithra N. R. 
Published: April 2020

Abstract
Temperature is an indispensable parameter of climate that triggers evapotranspiration and has vital importance in aggravating drought severity. This paper analyses the existence and persistence of drought conditions which are said to prevail in a tropical river basin which was once perennial. Past observed data and future climate projections of precipitation and temperature were used for this purpose. The assessment and projection of this study employ the Standardized Precipitation Evapotranspiration Index (SPEI) compared with that of the Standardized Precipitation Index (SPI). The results indicate the existence of drought in the past and the drought conditions that may persist in the future according to RCP 4.5 and 8.5 scenarios. The past drought years identified in the study were compared with the drought declared years in the state and were found to be matching. The evaluation of the future scenarios unveils the occurrence of drought in the basin ranging from mild to extreme conditions. It has been noted that the number of moderate and severe drought months has increased based on SPEI compared to SPI, indicating the importance of temperature in drought studies. The study can be considered as a plausible scientific remark helpful in risk management and application decisions.
Configuración económica de Baja California
Authors: García Montaño Jorge 
Published: April 2020

Este estudio tiene como finalidad realizar una comparación entre la economía de Baja California con la del resto del país, tomando en cuenta los cambios que han sufrido las actividades económicas del estado.También se plantea que Baja California, por su situación geográfica, desarrolla un modelo de crecimiento diferente al resto del país, haciendo hincapié en los factores que se encuentran relacionados con la economía internacional
Biomarkers of Acromegaly and Growth Hormone Action
Authors: Maffezzoni Filippo , Porcelli Teresa , Delbarba Andrea , Pezzaioli Letizia , Cappelli Carlo , Ferlin Alberto 
Published: April 2020

:
Biological markers (biomarkers) play a key role in drug development, regulatory approval
and clinical care of patients and are linked to clinical and surrogate outcomes.

:
Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to
important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers
for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth
factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly,
both GH and IGF-I are established biomarkers of disease activity.

:
However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their
role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore,
new biological markers for acromegaly and GH replacement therapy are strongly needed.

:
The aim of this paper is to review and summarize the current state in the field pointing out new
potential biomarkers for acromegaly and GH use/abuse.
Proteomic Investigations to Assess the Impact of Salinity on Vigna radiata L. Genotypes
Authors: Alharby Hesham F. , Hakeem Khalid Rehman 
Published: April 2020

Background:
In our previous study, six cultivars of Mungo (Vigna radiata) were exposed
to 100-250 mM NaCl and studied for changes in growth and biomass. Among them,
AEM-96 cultivar of the Mung bean [Vigna radiata (L.) Wilczek cv.] was found to tolerate NaCl
stress at 250 mM.

Objective:
The soluble proteome of salt-tolerant mungo cultivar (AEM-96) was compared to the
proteome of control mungo to investigate the possible mechanism of salinity tolerance.

Methods:
Gel-based two-dimensional gel electrophoresis was employed for comparative proteomics.
PDQuest-based image analysis of 2D SDS-PAGE was performed. Scatter plots were prepared
and total spots were analyzed for 2-fold changes in abundance of protein spot intensities in
control and treated gels.

Results:
In total 517 protein spots were detected; 36 with high significance. Among these 36 spots,
2-fold expression change was analyzed in 27 protein spots. Seven protein spots were upregulated,
eight spots were down-regulated, 3 spots were newly induced and 9 spots were silenced, while 9
protein spots did not change their 2-fold abundance under salinity. Protein spots (9 in total) which
were 2-fold upregulated and newly induced were excised from the respective gels. The spots were
tryptically digested and run on LC-MS/MS for generating peptides and performing a comparative
fingerprinting of the proteins. The peptide signal data was loaded on the Mascot (Swissprot)
database to retrieve protein IDs. Proteins with the best score were selected, namely isomers of oxygen-
evolving enhancer protein 1 (S1-S3), RuBisCO (S4), oxygen-evolving enhancer protein 2
(S5), Heat shock protein 70 isomers (S6-S7), RuBisCO activase (S8), rubber elongation factor (S9)
and pathogen-related protein 10 (S10).

Conclusion:
The identified proteins were found to play important roles in photosynthesis, stress response
and plant growth.
Multi-level Parallelization of Genotype Imputation on Supercomputers
Authors: Zhang Weiwen , Wang Long , Aye Theint Theint , Samsudin Juniarto , Zhu Yongqing 
Published: April 2020

Background:
Genotype imputation as a service is developed to enable researchers to estimate
genotypes on haplotyped data without performing whole genome sequencing. However, genotype
imputation is computation intensive and thus it remains a challenge to satisfy the high performance
requirement of genome wide association study (GWAS).

Objective:
In this paper, we propose a high performance computing solution for genotype imputation
on supercomputers to enhance its execution performance.

Method:
We design and implement a multi-level parallelization that includes job level, process level
and thread level parallelization, enabled by job scheduling management, message passing interface
(MPI) and OpenMP, respectively. It involves job distribution, chunk partition and execution,
parallelized iteration for imputation and data concatenation. Due to the design of multi-level
parallelization, we can exploit the multi-machine/multi-core architecture to improve the performance
of genotype imputation.

Results:
Experiment results show that our proposed method can outperform the Hadoop-based
implementation of genotype imputation. Moreover, we conduct the experiments on supercomputers to
evaluate the performance of the proposed method. The evaluation shows that it can significantly
shorten the execution time, thus improving the performance for genotype imputation.

Conclusion:
The proposed multi-level parallelization, when deployed as an imputation as a service,
will facilitate bioinformatics researchers in Singapore to conduct genotype imputation and enhance
the association study.
Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms
Authors: Hussein Abdelaziz M. , Eid Elsayed A. , Bin-Jaliah Ismaeel , Taha Medhat , Lashin Lashin S. 
Published: April 2020

Background and Aims:
In the current work, we studied the effects of exercise and stevia
rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible
underlying mechanisms.

Methods:
: Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal
control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c)
DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts:
type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum
blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative
stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression
of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues
were measured.

Results:
T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and
LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2
and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05).
On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied
parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05).

Conclusion:
Both exercise and methanolic stevia R extracts showed cardioprotective effects against
DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these
lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density
and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.
Risk Control Study Based on the Digital Recording Technology Industry Investment Projects in “Internet +”
Authors: Yan Zhou 
Published: April 2020

Background:
The reform and innovation of recording technology have resulted in recording
becoming an exciting, developing project. Against the background of Internet +, traditional
analogue technology has developed into digital recording technology, playing an important role in
various fields. Venture capital in digital recording technology projects has also attracted attention
from all circles.

Objective:
This paper aims to, by sorting out literature on venture capital, analyze the measurement
method of project investment risk, and then, after analyzing the risk factors existing in the investment
of digital recording technology under the “Internet +”, propose measures to control these risk
factors. At the same time, taking CY company as an example, the investment risk prevention strategy
of digital recording technology project is applied to the risk investment evaluation practice of CY
company.

Methods:
This paper reviews and comments the literature on venture capital, and sorts out the evaluation
methods of project investment risk. After studying the project investment risk of digital recording
technology, this paper finds out the preventive strategies to deal with these risks, and applies
them to risk investment evaluation of CY. This paper proposes investment suggestions based
on various factors, and makes an overall evaluation of the value of digital recording technology project,
which hopefully will act as a reference for venture capital institutions when investing in digital
recording technology in the future.

Results:
The countermeasures against investment risks in digital recording technology projects are:
1. Identification of countermeasures against investment risks in digital recording technology projects.
2. Encouragement and promotion of joint-stock cooperation and reduction of operational risks
3. Establishment and improvement of financial risk control.

Conclusion:
Digital technology, which is continuously improving, has penetrated recording technology.
With mindful awareness of investment risks and careful investment in recording technology
projects, digital technology can improve living standards while making the flexibility and form of
recording work more artistic and enabling recording technology to reach new heights.
Water-Zeolite Interfaces for Controlling Reaction Routes in Fischer- Tropsch Synthesis of Alternative Fuels
Authors: Mordkovich Vladimir Z. , Sineva Lilia V. 
Published: April 2020

Background:
The Fischer-Tropsch Synthesis (FTS) remains an important process for motor
fuel production from CO and H2. The composition of the FTS products (hydrocarbon mixtures) depends
on the properties of a catalyst and on the process conditions.

Summary:
The introduction of zeolites into catalytic systems can alter the molecular weight distribution
paving the way to tailor-made fuels, as was revealed by recent research results produced in the laboratories
worldwide. The AlO4 and SiO4 tetrahedrons, which constitute the zeolites, are able to transfer
electrons and ions in a way, which makes water-zeolite interfaces capable of initiating active carbonium
ions. It was shown in a number of works that the water-zeolite interface plays a key role in diverting
the FTS from the classical route.

Conclusion:
This review gives a critical analysis of literature data on the role of water-zeolite interfaces
on FTS cobalt catalysts and on the interactions of hydrophobic and hydrophilic zeolites with water.
Research on Position / Velocity Synergistic Control of Electro Hydraulic Servo System
Authors: Gao Bingwei , Ye Yongtai 
Published: April 2020

Background:
In some applications, the requirements of electro-hydraulic servo system
are not only precise positioning, but also the speediness capability at which the actuator is operated.

Objective:
In order to enable the system to achieve rapid start and stop during the work process,
reduce the vibration and impact caused by the change of the velocity, at the same time improve the
positioning accuracy, and further strengthen the stability and the work efficiency of the system, it
is necessary to perform the synergistic control between the position and the velocity of the electrohydraulic
servo system.

Methods:
In order to achieve synergistic control between the position and the velocity, a control
method of velocity feed-forward and position feedback is adopted. That is, based on the position
control, the speed feed-forward is added to the outer loop as compensation. The position control
adopts the PID controller, and the velocity control adopts the adaptive fuzzy neural network controller.
At the same time, the position and velocity sensors are used for feedback, and the deviation signals
between the position and the velocity obtained by superimposing the feedback are used as the
final input of the control object, thereby controlling the whole system.

Results:
The control effect of the designed position / velocity synergistic controller is verified by
simulation and experiment. The results show that the designed controller can effectively reduce the
vibration and impact caused by the change of the velocity, and greatly improve the response velocity
and the position accuracy of the system.

Conclusion:
The proposed method provides technical support for multi-objective synergistic control
of the electro-hydraulic servo system, completes the requirements of multi-task operation, improves
the positioning accuracy and response velocity of the electro-hydraulic servo system, and realizes the
synergy between the position and the velocity. In this article, various patents have been discussed.