bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultra‐narrow border display with a cover glass using liquid crystal displays with a polyimide substrate
Authors: Oka Shinichiro , Hyodo Yosuke , Jin Lu , Asozu Genki , Kaneda Hiromi , Mochizuki Kazuhide , Mochizuki Marina , Aoki Yoshiro , Asano Naoyuki 
Published: April 2020

AbstractPlastic liquid crystal displays (LCDs) termed sheet LCDs with transparent polyimide (PI) substrates were constructed. There is a lot of potential to expand the use of these LCDs in LCD applications. Herein, we investigated a structure for sheet LCDs such as high‐density main post spacers (PSs) and PI substrates with the aid of a barrier layer to control the residual stress and protect the liquid crystal from moisture.Drawing on this, we propose an ultra‐narrow border LCD that makes of the developed sheet LCDs. The most significant improvement is that the four borders of the LCD can be folded to wrap the backlight unit. This LCD was based on various new techniques, including the use of plastic substrates, processing of polarizer films, control of the neutral surface of a bending component based on the sealant width, and the use of a cover glass with a lens effect. We believe that these novel LCDs will be useful in numerous new applications.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer
Authors: Yao Fu‐Zhou , Kong De‐Gang 
Published: April 2020

AbstractGastric cancer (GC) is the fourth most common malignancy worldwide, with 80% mortality rate in over 70% countries. Recently, targeted therapy for GC has great clinical prospects, and it is still badly needed to find novel molecular targets to control the progression and development of GC. Kinesin family member 3B (KIF3B) is known as a microtubule motor kinesin and one of the most ubiquitously expressed KIFs. KIF3B participates in multiple cellular processes such as mitosis and spermatogenesis, and the possible role of KIF3B on tumor progression has been widely revealed. KIF3B affects the progression and metastasis of multiple types of tumors, such as pancreatic cancer, prostate cancer, and hepatocellular carcinoma; however, its potential impact on GC is still unknown. Herein, we explored the possible role of KIF3B on the progression of GC and noticed that KIF3B was high expression in tumor tissues from GC patients. KIF3B was also significantly correlated with clinical pathological characteristics such as tumor size (P = .014*) and recurrence (P = .044*). We further revealed that KIF3B depleted GC cells exhibited impaired proliferation capacity in vitro. Similarly, KIF3B depletion suppressed tumor growth of GC cells in mice. In conclusion, we identified KIF3B as a promising therapeutic target for the treatment of GC.
Drivers of a sudden mesoscale rainstorm in arid and semi‐arid regions at the edge of the western Pacific subtropical high
Authors: Liu Jing , Zhang Jinru , Liu Fan , Yang Lianmei 
Published: April 2020

AbstractAn extreme rainstorm occurred in southeastern Hami in Xinjiang, China, on July 31, 2018. The region experienced maximum accumulated precipitation of 110 mm over 12 h, causing a flood that killed 20 people and left eight missing. The present study uses multiple data sources in order to conduct an in‐depth analysis of this extreme rainfall event. Results show that the western Pacific subtropical high (WPSH) could directly impact the arid and semi‐arid areas under the certain circulation patters. During the heavy rainfall period, the 500 hPa WPSH was anomalously northerly; several mesoscale cloud clusters generated in front of the 700 hPa Hexi corridor jet stream and then merged and developed along the 500 hPa steering flow. The atmosphere was conditionally unstable over the region, and unstable convective energy was triggered by warm frontogenesis at the low Troposphere. Warm frontal frontogenesis was determined by the horizontal divergence and the tilt term during convective initiation, and deformation and tilt terms as convective cloud at matured. Additionally, the intensification of the 700 hPa Hexi corridor southeasterly jet and topographic uplifting were responsible for the long‐term persistence of the mesoscale convective system, which should be paid more attention by forecasters in the future forecasting of this region.
A microwave amplifier behavioral model capable of cascade simulation
Authors: Xie Chengcheng , Yu Gang , Zhang Ziheng , Wang Huanpeng , Li Youda , Wu Yunqiu , Guo Yunchuan , Xu Ruimin , Xu Yuehang 
Published: April 2020

AbstractIn system‐level design, microwave amplifier needs to be cascaded with other components. In this scenario, the input and output of amplifier model have cascade capability to sense the variation of source and load impedance, and thus can accurately predict the forward and reverse propagating waves. In this letter, the principle and an extraction flow for a simplified polynomial behavioral model are introduced, and the cascade capability of the model is verified by experimental source‐pull and load‐pull results. By simulations, a subcircuit with a low noise amplifier and a power amplifier, which are cascaded, is used to establish behavioral models using the proposed method. It shows that the proposed model results have good agreement with circuits using both continuous wave and modulated signal excitation. Finally, by measurements, the cascaded results of two amplifiers models are compared with the overall results. The results of output waves and magnitude/phase up to third harmonics are consistent with each other. These results verify that the proposed behavioral model has the capability of cascade simulation.
Bandwidth enhancement using a slot‐inverted F hybrid antenna for metal frame devices
Authors: Kim Jae Hee 
Published: April 2020

AbstractFor a wireless communication device surrounded by a metal frame, a slot antenna is required to ensure antenna performance. However, the closed slot antenna, which is blocked by metal on all sides, has a disadvantage of narrow bandwidth when the aperture size is small. In this study, a method for widening the bandwidth by integrating the closed slot antenna with an inverted F antenna is proposed herein. Using this method, the inverted F antenna is mounted on the slot antenna, and the feeding structure is set up to merge the resonance frequencies of the two antennas. The proposed antenna is fabricated and is measured to have a bandwidth of 450 MHz (2.3 to 2.75 GHz) at 2.4 GHz for S11 < −10 dB. The measured efficiency is over 75% in this frequency band. The proposed method is expected to be used to widen the bandwidth of antennas for metal‐framed devices with insufficient antenna mounting space.
A novel wideband planar Ku‐band array antenna for omnidirectional radar
Authors: Zhang Fuheng , Yang Guo‐Min 
Published: April 2020

AbstractThis aticle presents a new wideband omnidirectional array antenna that operates at Ku‐band. Each element of the array antenna consists of a modified planar bow‐tie dipoles radiator, a pair of parasitic strips, and a pair of directors. The parasitic strips and directors are designed to enhance the antenna omnidirectional radiating performance. All elements are combined through a double‐sided parallel strip‐line feeding network. A wideband semicircular balun is employed at the feeding port to broaden the impedance bandwidth. Finally, a 2 × 2 prototype is designed, fabricated, and measured. The measured results demonstrate that the proposed array antenna provides 47.3% (11.3‐18.4 GHz) relative impedance bandwidth with 4.1 dBi maximum gain, around 44.8° half‐power beamwidth at 15.0 GHz and less than 2.5 dB unroundness over the whole operating band in xoy plane.
Investigation of the thermoformability of various D‐Lactide content poly(lactic acid) films by ball burst test
Authors: Pölöskei Kornél , Csézi Gergely , Hajba Sándor , Tábi Tamás 
Published: April 2020

AbstractIn this article, we investigated the thermoformability of poly(lactic acid) (PLA) films with various D‐Lactide contents and therefore different crystallization properties, performing tensile and ball burst tests at various temperatures and testing rates. We found that the behavior of the PLA films tested above the glass transition temperature significantly differs due to the difference in D‐Lactide content, and thus crystallinity. During tensile testing, elevated temperatures and mechanical stress caused the crystallization temperature to decrease and thus highly induced crystallization. At the same time, as testing speed was increased, the ability of the polymer to crystallize decreased. In ball burst tests, the PLA films crystallized more than during tensile testing. We described the differences found between tensile testing and ball burst testing, which latter better represents the conditions of thermoforming through inducing biaxial deformation.
Preparation andoil–waterseparation evaluations of polypropylene/low‐melt‐point polyester composites reinforced by thermal bonding and one‐step solution immersion
Authors: Sun Fei , Li Ting‐Ting , Zhang Xiayun , Shiu Bing‐Chiuan , Zhang Yue , Lou Ching‐Wen , Lin Jia‐Horng 
Published: April 2020

AbstractNonwoven fabrics have been fabricated for oil–water separation, but simplifying the manufacturing processes is still a challenge. In this work, a facile and easily scaled up approach based on thermal bonding and one‐step solution immersion has been successfully developed to prepare nonwoven fabrics with high separation efficiency and flux of oil. Here, polypropylene (PP) and low‐melt‐point polyester (LPET) fibers with a unique sheath–core structure are employed to form PP/LPET nonwoven fabrics. Thermal bonding by hot press and hydrophobic treatment with 1H,1H,2H,2H‐perfluorodecyl‐1‐thiol (PFDT) are used to manufacture oil–water separation nonwoven fabrics. Effects of the ratio of LPET fibers and the concentration of PFDT are discussed in terms of mechanical properties, morphology, surface chemical composition, water contact angle and performance of oil–water separation and flux of the nonwoven fabrics. The results show that the strength of the nonwoven fabrics gradually increases with increasing ratio of LPET fibers. After immersion in PFDT, the nonwoven fabrics show high hydrophobicity with a water contact angle of 143°. They can be used to separate oil–water mixtures. The separation efficiency is 97–99% and the oil flux is 62 364.92 L m−2h−1. This study provides a new prospect for simple introduction of a hydrophobic agent on a nonwoven fabric to achieve various functional oil–water separation materials. © 2020 Society of Chemical Industry
Overexpression of miR‐455‐5p affects retinol (vitamin A) absorption by downregulating STRA6 in a nitrofen‐induced CDH with lung hypoplasia rat model
Authors: Zheng Jintao , He Qiuming , Tang Huajian , Li Jiequan , Xu Huiyu , Mao Xiangming , Liu Guoqing 
Published: April 2020

AbstractLung hypoplasia is the main cause of congenital diaphragmatic hernia (CDH)‐associated death but pathogenesis remains unclear. MiR‐455‐5p is involved in lung hypoplasia. We hypothesized that nitrofen causes abnormal miR‐455‐5p expression during lung development and designed this study to determine the relationship between miR‐455‐5p, stimulated by retinoic acid 6 (STRA6), and retinol in a nitrofen‐induced CDH with lung hypoplasia rat model. Nitrofen or olive oil was administered to Sprague‐Dawley rats by gavage on day 9.5 of gestation, and the rats were divided into a nitrofen group and a control group (n = 6). The left lung of fetuses was dissected on day 15.5. The expression of miR‐455‐5p or STRA6 messenger RNA (mRNA) was determined by quantitative real‐time polymerase chain reaction. Average integrated optical density (IOD) of STRA6 protein was determined by immunofluorescence histochemistry. The average retinol level was detected by enzyme‐linked immunosorbent assay (n = 6 lungs, respectively). Compared with the control group, the nitrofen group exhibited significantly increased miR‐455‐5p expression levels (29.450 ± 9.253 vs 5.955 ± 2.330; P = .00045) and significantly decreased STRA6 mRNA levels (0.197 ± 0.097 vs 0.588 ± 0.184; P = .0047). In addition, the average IOD of the STRA6 protein was significantly lower in the nitrofen group (805.643 ± 291.182 vs 1616.391 ± 572.308, P = .015), and the average retinol level was significantly reduced (4.013 ± 0.195 vs 5.317 ± 0.337 µg/L, P = .000). In summary, the overexpression of miR‐455‐5p affected retinol absorption by downregulating STRA6 in the nitrofen‐induced CDH with lung hypoplasia rat model, and this downregulation may be one cause of CDH with lung hypoplasia.
Comparison of delivered distending pressures in the oropharynx in preterm infant on bubble CPAP and on three different nasal interfaces
Authors: Sharma Deepak , Murki Srinivas , Maram Shravani , Pratap Tejo , Kiran Sai , Venkateshwarlu Vardhelli , Dinesh Pawale , Kulkarni Dattatray , Kamineni Bhargavi , T. Anusha , Singh Gurmeet 
Published: April 2020

AbstractObjectiveTo compare the level of continuous positive airway pressure (CPAP) delivered by three different CPAP delivery interfaces (RAM cannula system, Hudson prongs, and nasal mask) in preterm neonates with respiratory distress.MethodsPreterm neonates with gestation between 28 weeks and 34 weeks and birth weight more than or equal to 1000 g and requiring nasal CPAP for respiratory distress were eligible for the study. During the study period, consecutive infants requiring CPAP were started on Hudson prongs or RAM cannula or nasal mask in that order. We measured the mean oropharyngeal pressure, which approximates the applied CPAP level. Oropharyngeal pressures in the recruited neonates were measured between 24 and 48 hours of postnatal age, when stable and in sleep or quiet awake state. Comparison of the delivered oropharyngeal pressures when on three different nasal interfaces at the same set flow rate and at set CPAP of 5 cm or 6 cm of H2O was the primary outcome.ResultsData was analyzed from 30 neonates in each group. We found that measured oropharyngeal pressures were less than set CPAP level in all three studied interfaces. Maximum drop in oropharyngeal pressure was observed with use of RAM cannula with measured oropharyngeal pressures being 1.1 and 1.2 cm H2O less than set CPAP of 5 and 6 cm H2O respectively. Pharyngeal pressure best correlated to set CPAP level with the use of nasal mask.ConclusionNone of the nasal interfaces delivered oropharyngeal pressure equivalent to the set CPAP. However, nasal mask delivered oropharyngeal pressure best matched to the set CPAP.
Deep Proteomic Insights into the Individual Short‐Term Pellicle Formation on Enamel—An In Situ Pilot Study
Authors: Trautmann Simone , Künzel Nicolas , Fecher‐Trost Claudia , Barghash Ahmad , Schalkowsky Pascal , Dudek Johanna , Delius Judith , Helms Volkhard , Hannig Matthias 
Published: April 2020

PurposeDental pellicle formation starts instantaneously after oral hygiene due to the adsorption of salivary proteins to all orally exposed surfaces. The pellicle acts as a physiological mediator, protects the tooth surface from mechanical damages and reduces acid‐induced enamel demineralization. The aim of this pilot study is to identify and characterize individual proteomic profiles of the initial pellicle formed on dental enamel and to compare the profiles with the corresponding saliva to analyze specific adsorption patterns occurring during pellicle formation.Experimental DesignThe 3‐min pellicle of five subjects formed in situ on bovine enamel is eluted chemically and analyzed separately by nano‐mass spectrometry. The analysis of the corresponding saliva is conducted in parallel.ResultsUp to 498 pellicle proteins and up to 1032 salivary proteins are identified on an individual level. Comparison of the salivary and pellicle protein profiles demonstrates the pellicle formation to be highly individual. Nineteen proteins are significantly enriched in the 3‐min pellicle of all subjects and 22 proteins are significantly depleted indicating that pellicle formation relies on selective adsorption.Conclusions and Clinical RelevanceThe short‐term enamel pellicle is composed of several hundreds of adsorbed salivary proteins and reveals a highly individual proteomic profile.
On the dual linear periodic time‐delay system: Spectrum and Lyapunov matrices, with application to analysis and balancing
Authors: Michiels Wim , Gomez Marco A. 
Published: April 2020

SummaryWe present novel theoretical concepts for linear time‐periodic systems with multiple delays, which are closely related to the spectral properties and Lyapunov matrices. At the basis of the main results is the associated dual system, constructed by transposition of the systems matrices and affine transformations of their arguments. We introduce, for the first time, the concepts of the norm and the dual Lyapunov matrix of periodic systems with delays. We show that the primal and dual system have the same norm, characterized by primal and dual delay Lyapunov equations, which extend the well‐known results for time‐invariant systems with delays, and periodic systems without delays. Having at hand the pair of primal‐dual Lyapunov matrices, along with some energy interpretations, allow us to generalize the concept of position balancing and explore its potential for model reduction. The obtained results are illustrated by several examples, including the delayed Mathieu equation.
Design, Synthesis and Antimicrobial Evaluation of 1,3,4‐Oxadiazole/1,2,4‐Triazole‐Substituted Thiophenes
Authors: Singla Nishu , Singh Gagandeep , Bhatia Rohit , Kumar Anoop , Kaur Rupinder , Kaur Satvinder 
Published: April 2020

AbstractThe increasing level of antimicrobial resistance in pathogenic bacteria, together with the lack of new potential drug scaffolds in the pipeline, make the problem of infectious diseases a major public health concern. Thus, in this context, a novel series of 1,3,4‐oxadiazole‐substituted thiophenes (4 a–m) and 1,2,4‐triazole (6 a–m) substituted thiophene derivatives were synthesized. Characterization of all the synthesized derivatives was done by various spectroscopic techniques such as 1H NMR, 13C NMR spectroscopy and mass spectrometry, and evaluated for antimicrobial activity against various pathological strains using broth dilution and disc diffusion method. In particular, compound 6 e and 4 e exhibited significant inhibitory potential with MIC ranging from 2–7 μg mL−1 against S. aureus, B. subtilis, P. aeruginosa and E. coli. Additionally, compound 6 e was found to be highly potent against methicillin resistant S. aureus (MRSA; MIC=2 μg mL−1). Molecular docking studies were also performed to confer the possible mode of action and association studies indicate the binding of potent active compound with DHFR enzyme (Ka=2.10×103 M−1). Further, the mechanism of action has also been explored by atomic force microscopy (AFM), which reveals the bacterial cell wall deformity and cell wall rupturing that may lead to bacteria cell death. Additionally, in silico ADME prediction study suggested the drug like properties of active compounds.
The Role of Delocalization Energy on Superhalogen Property: The Electron Affinity of , , and (X=O, S, and Se)
Authors: Farrokhpour Hossein , Yousefvand Mostafa , Hadadzadeh Hassan , Jouypazadeh Hamidreza 
Published: April 2020

AbstractThe electron affinities (EAs) of manganese compounds including
,
and
(X=O, S, and Se; n=0 to 6) species were calculated. The calculated EAs of neutral species are positive, while the EA values of anions remain negative. The increase of the EA value among the number of X atoms for the neutral species was observed so that
(EA=+5.04 eV),
(EA=+4.61 eV), and
(EA=+6.58 eV) all revealed superhalogen property. To interpret the variation of EA with n and number of X atoms, the change in the partial charges of atoms, the electrostatic surface potential (ESP) of species, the strength of Mn−X bonds, the delocalization energy, and the energy components of electronic energy of species were examined. The positive EA of some neutral species is attributed to the increase of delocalization energy due to the added electron. In contrast, for some species, the decrease of delocalization energy is observed despite having a positive EA. For these species, the decomposition of electronic energies provides a reasonable interpretation of the positive EA value.
It takes more than two to tango: mechanosignaling of the endothelial surface
Authors: Fels Benedikt , Kusche-Vihrog Kristina 
Published: April 2020

AbstractThe endothelial surface is a highly flexible signaling hub which is able to sense the hemodynamic forces of the streaming blood. The subsequent mechanosignaling is basically mediated by specific structures, like the endothelial glycocalyx building the top surface layer of endothelial cells as well as mechanosensitive ion channels within the endothelial plasma membrane. The mechanical properties of the endothelial cell surface are characterized by the dynamics of cytoskeletal proteins and play a key role in the process of signal transmission from the outside (lumen of the blood vessel) to the interior of the cell. Thus, the cell mechanics directly interact with the function of mechanosensitive structures and ion channels. To precisely maintain the vascular tone, a coordinated functional interdependency between endothelial cells and vascular smooth muscle cells is necessary. This is given by the fact that mechanosensitive ion channels are expressed in both cell types and that signals are transmitted via autocrine/paracrine mechanisms from layer to layer. Thus, the outer layer of the endothelial cells can be seen as important functional mechanosensitive and reactive cellular compartment. This review aims to describe the known mechanosensitive structures of the vessel building a bridge between the important role of physiological mechanosignaling and the proper vascular function. Since mutations and dysfunction of mechanosensitive proteins are linked to vascular pathologies such as hypertension, they play a potent role in the field of channelopathies and mechanomedicine.