bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Recognition of Facial Emotion in Patients With Parkinson Disease Under Dopamine Therapy
Authors: Palmeri Rosanna , Buono Viviana Lo , Bonanno Lilla , Allone Cettina , Drago Nancy , Sorbera Chiara , Cimino Vincenzo , di Lorenzo Giuseppe , Bramanti Alessia , Marino Silvia 
Published: October 2019

Introduction: Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms. The impaired ability to recognize facial emotion expressions represents an important nonmotor symptom. The aim of this study is to investigate the ability in recognizing facial emotion expressions in patients with PD under dopamine replacement therapy. Methods: Thirty medicated patients with PD and 15 healthy controls (HC) were enrolled. All participants performed the Ekman 60-Faces test for emotional recognition. All patients underwent a neuropsychological evaluation for global cognitive functioning, depression, and anxiety. Results: Patients with PD were impaired in recognizing emotions. Significant differences between PD and HC were found in Ekman 60-Faces test scores ( P < .001), and in Ekman 60-Faces test subscales, in particular, sadness, fear, disgust, anger, and surprise ( P < .001). Conclusions: The nigrostriatal dopaminergic depletion seems to determine emotional information processing dysfunction. This relevant nonmotor symptom could have consequences in daily living reducing interactions and social behavioral competence.
Factor Xa inhibitors for preventing recurrent thrombosis in patients with antiphospholipid syndrome: a longitudinal cohort study
Authors: Sato T , Nakamura H , Fujieda Y , Ohnishi N , Abe N , Kono M , Kato M , Oku K , Bohgaki T , Amengual O , Yasuda S , Atsumi T 
Published: October 2019

Objective The objective of this study was to clarify the efficacy and safety of factor Xa inhibitors for antiphospholipid syndrome patients in real world utilization. Methods This is a retrospective cohort study comprised of all consecutive patients with antiphospholipid syndrome in our department over a period of 28 years. Patients treated with factor Xa inhibitors were extracted from the cohort. As a control group, patients treated with warfarin were selected from the same cohort with matched age, gender, coexistence of systemic lupus erythematosus, and the presence of antiplatelet therapy, after which we used a propensity score for each of the risk factors as an additional covariate in multivariate Cox proportional hazard regression. The primary endpoint was set as thrombotic and hemorrhagic event-free survival for five years. Results Among 206 patients with antiphospholipid syndrome, 18 had a history of anti-Xa therapy (five rivaroxaban, 12 edoxaban, one apixaban). Fourteen out of 18 patients on anti-Xa therapy had switched to factor Xa inhibitors from warfarin. Event-free survival was significantly shorter during anti-Xa therapy than that during warfarin therapy (hazard ratio: 12.1, 95% confidence interval: 1.73–248, p = 0.01) ( Figure 1(a) ). Similarly, event-free survival in patients treated with factor Xa inhibitors was significantly shorter compared with controls (hazard ratio: 4.62, 95% confidence interval: 1.54–13.6, p = 0.0075). In the multivariate Cox proportional hazard model, event-free survival in patients with anti-Xa therapy remained significantly shorter (hazard ratio: 11.9, 95% confidence interval: 2.93–56.0, p = 0.0005). Conclusions Factor Xa inhibitors may not be recommended for antiphospholipid syndrome.
Risk factors of infection-associated mortality in children with lupus nephritis in under-resourced areas
Authors: Rianthavorn P , Prurapark P 
Published: October 2019

Introduction Treatment of lupus nephritis class III, IV and V with immunosuppressive therapy increases patient survival but poses a risk of infection-related mortality. This study was conducted to evaluate risk factors for fatal infection in children with lupus nephritis in under-resourced areas. Methods Medical records of patients, who were admitted to a tertiary-care university-based hospital from January 2002 to July 2018 with the diagnosis of systemic lupus erythematosus, were reviewed. Only patients aged less than 18 years with lupus nephritis and documented infection were included in the study. The primary outcome was infection-associated mortality. The logistic regression model was used to identify independent variables associated with fatal infection. Predicted probabilities of infection-related mortality adjusted for factors significant in multivariate analysis were calculated using marginal effects at representative values. Results Infection-related deaths occurred in 27 of 179 patients (15.1%). Hospital-acquired infections occurred in 72 of 375 episodes of hospital admissions (19.2%) and 13 hospital-acquired infections (18.1%) resulted in fatal infection. Invasive fungal infections were the leading cause of death (44.4%) and pulmonary infections were the predominant site (55.5%). Haemoglobin levels and glomerular filtration rates were significantly lower in deceased versus surviving patients. Percentages of patients with hospital-acquired infections, invasive fungal infections and pulmonary infections were significantly higher in deceased than surviving patients. Urine protein, the neutrophil-to-lymphocyte ratio, cumulative methylprednisolone dose and daily prednisolone dose were significantly higher in deceased than surviving patients. In multivariate analysis, a neutrophil-to-lymphocyte ratio more than 20, invasive fungal infections and high daily prednisolone dose were independently predictive of fatal infection with adjusted odds ratio of 3.02 (95% confidence interval 1.02–8.97, p = 0.04), 15.08 (95% confidence interval 4.72–48.24, p < 0.001) and 1.03 (95% confidence interval 1.01–1.06, p = 0.04), respectively. A high daily prednisolone dose intensified the impact of invasive fungal infections and high neutrophil-to-lymphocyte ratio on predicted probability of infection-associated mortality. Conclusions Prevention of invasive fungal infections and minimization of daily prednisolone should be emphasized in routine clinical practice of children with lupus nephritis in under-resourced areas to achieve better survival. Children with lupus nephritis and a high neutrophil-to-lymphocyte ratio should be under cautious surveillance for infection.
Secondary acute angle closure attack as an initial presentation of a novel type of systemic lupus erythematosus
Authors: Sun H -S , Kong X -Y , Bai Y -Y , Li M , Hu N -W 
Published: October 2019

Background We report a rare case of secondary acute angle closure attack because of lupus choroidopathy and accompanying polyserositis, as an initial presentation of a novel type of systemic lupus erythematosus in a 44-year-old woman. Case presentation The patient complained of eyelid oedema and chemosis with bilateral severe loss of visual acuity. Systemic lupus erythematosus was diagnosed based on malar rash, polyserositis, proteinuria and positive antibody titers for antinuclear antibodies, anti-DNA, antinucleosome antibodies and ribosomal RNP. Subsequently, secondary bilateral acute angle closure caused by choroidal effusions with lupus choroidopathy was diagnosed. A month after steroid and immunosuppressive drug therapy, the patient’s intraocular pressure and visual acuity returned to normal. During the subsequent year, the secondary acute angle closure did not recur and polyserositis remained under control. Conclusions Bilateral, secondary acute angle closure attack due to SLE choroidopathy can be an initial presentation of SLE, which is often accompanied by polyserositis. Prompt and aggressive high doses of steroids and immunosuppressive therapy are strongly recommended.
Small and Medium Enterprises Export by Indian Regions: Uncovering the Role of Spatial Factors
Authors: Husain Tareef 
Published: October 2019

The present study uncovers the critical regional factors essentially responsible for inter-state small and medium enterprises (SMEs) export differences. In this context, this study is useful from the perspective of regional/local policy implications, as it is focused on critical regional determinants of SMEs’ export. Based on a wide range of interconnected theories, this study designs an analytical framework comprising a set of regional factors, which are proposed to have a significant impact on export capabilities of local SMEs. The empirical results indeed confirm the relation significantly. States with larger and productive SMEs are more successful in export activities. Likewise, Indian states may enhance their SMEs’ export by focusing on regional factors such as market, skill and power generation capacity. JEL Classification: F12, F14, R12
Olanzapine as a rescue antiemetic in hematopoietic stem cell transplant
Authors: Monson Taylor , Greer Devon , Kreikemeier Emily , Liewer Susanne 
Published: October 2019

Background Chemotherapy-induced nausea and vomiting occurs in up to 80% of patients undergoing chemotherapy treatment and is associated with a deterioration in quality of life. Olanzapine is an atypical antipsychotic antagonist blocking a variety of neurotransmitters in the nausea and vomiting pathophysiology. Objectives The primary objective of this study is to determine whether olanzapine is associated with improved breakthrough nausea and vomiting in patients undergoing hematopoietic stem cell transplant. Secondary outcomes include number of documented emesis episodes, an evaluation of patient oral intake, and number of rescue antiemetic agents administered after olanzapine initiation. Methods This is a retrospective cohort review examining the effects of olanzapine for the treatment of breakthrough nausea and vomiting following hematopoietic stem cell transplant. Patients undergoing autologous or allogeneic hematopoietic stem cell transplant between January 2014 and October 2017 were included. Results A total of 150 patients were included in the study. Olanzapine use was associated with a complete response in 30% of patients for breakthrough chemotherapy-induced nausea and vomiting (p < 0.0001). An improvement in nausea (p < 0.0001) and vomiting (p = 0.02) was also observed in patients. Olanzapine administration was associated with lower as needed antiemetic usage (p < 0.0001) as well as fewer emesis episodes (p < 0.0001) but had no effect on oral intake (p = 0.13). Conclusions Olanzapine was associated with significant improvements in breakthrough nausea and vomiting control while reducing the number of emesis episodes and required antiemetic doses in the hematopoietic stem cell transplant population. Olanzapine may be beneficial in optimizing antiemetic regimens for breakthrough chemotherapy-induced nausea and vomiting control in patients undergoing hematopoietic stem cell transplant.
The Relationship Between Cytokine Production, CSF2RA, and IL1R2 Expression in Mammary Adenocarcinoma, Tumor Histopathological Parameters, and Lymph Node Metastasis
Authors: Autenshlyus Alexander , Arkhipov Sergey , Mikhailova Elena , Marinkin Igor , Arkhipova Valentina , Varaksin Nikolay 
Published: October 2019

Objective: The aim of this study was to evaluate the relationship between cytokine production, GM-CSF receptor (CSF2RA), and IL-1 receptor (IL1R2) expression in mammary adenocarcinoma and their association with it histopathological parameters and lymph node metastasis. Methods: We analyzed tumor biopsy samples (cultured in vitro) from 50 women (aged 43-75) with invasive ductal mammary adenocarcinomas. Enzyme-linked immunosorbent assay method the concentrations of interleukin 2, interleukin 6, interleukin 8, interleukin 10, interleukin 17, interleukin 18, interleukin 1β, interleukin 1Ra, tumor necrosis factor α, interferon γ, granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor, and vascular endothelial growth factor A were determined in culture supernatants. The expression of CSF2RA and IL1R2 in tumor biopsy was evaluated by immunohistochemical method. Results: We showed that the “cytokine profile” of a tumor (the ability of tumor cells and its microenvironment to produce different cytokines) is very individual. It has been shown that the features of the cytokine profile of the mammary adenocarcinoma are important for the formation and realization of the metastatic potential of the mammary adenocarcinoma. We found correlations between some histopathological parameters of mammary adenocarcinoma and coefficients KGM-CSF/CSF2RA and KIL-1β/IL1R2, which are the ratios of concentrations of granulocyte macrophage colony-stimulating factor and interleukin -1β to expression of CSF2RA and IL1R2, respectively. KGM-CSF/CSF2RA positively correlated with highly differentiated cells, and KIL-1β/IL1R2 positively correlated with the number of mitoses, poorly differentiated cells, and a number of lymph nodes with metastases. KGM-CSF/CSF2RA positively correlated with the concentrations of interleukin 6, interleukin 8, interleukin 1Ra, and granulocyte colony-stimulating factor. KIL-1β/IL1R2 positively correlated with concentrations of interleukin 1β and interferon γ and negative correlated with the concentrations of vascular endothelial growth factor A and tumor necrosis factor α. It is shown that KIL-1β/IL1R2 can be considered as a prognostic indicator predicting the probability of mammary adenocarcinoma metastasis to regional lymph nodes. Conclusions: The ratios of granulocyte macrophage colony-stimulating factor and interleukin 1β cytokines, produced in tumor, to the expression of CSF2RA and IL1R2 depend on levels of interleukin 6, interleukin 8, tumor necrosis factor α, interferon γ, granulocyte colony-stimulating factor, and vascular endothelial growth factor A and are important factors affecting the progression and metastasis of the breast cancer.
More severe cold intolerance is associated with worse sensory function after peripheral nerve repair or decompression
Authors: Cesim Özge B. , Öksüz Çiğdem 
Published: October 2019

The aim of the study is to investigate the correlation between cold intolerance and sensory function after repair of nerve transection or decompression of peripheral neuropathy in the upper extremity. We included patients with abnormal cold sensitivity who had a score of 30 or more in the Cold Intolerance Symptom Severity Questionnaire. There were 30 individuals after surgery to repair nerve transection and 30 with compression neuropathy, aged between 18–65 years. We used the Cold Intolerance Symptom Severity Questionnaire to evaluate cold intolerance and the Rosen Score to evaluate sensory function. There was a significant negative correlation between cold intolerance and sensory function in both peripheral nerve transections and compression neuropathies. We conclude that greater cold intolerance is associated with worse sensory function in peripheral nerve injuries. Interventions for sensory function in cold intolerance treatment may reduce the severity of cold intolerance. Level of evidence: III
Long-term outcome after ischemic stroke in relation to comorbidity – An observational study from the Swedish Stroke Register (Riksstroke)
Authors: Sennfält Stefan , Pihlsgård Mats , Petersson Jesper , Norrving Bo , Ullberg Teresa 
Published: October 2019

Purpose Comorbidity in stroke is common, but comprehensive reports are sparse. We describe prevalence of comorbidity and the prognostic impact on mortality and functional outcome in a large national ischemic stroke cohort. Methods We used outcome data from a long-term follow-up survey conducted in 2016 by the Swedish Stroke Register (Riksstroke). Those included in the study were 11 775 pre-stroke functionally independent patients with first-ever ischemic stroke followed up at three months and 12 months (all patients), and three years (2013 cohort) or five years (2011 cohort). Pre-stroke comorbidity data for 16 chronic conditions were obtained from the Swedish National Patient Register, the Swedish Prescribed Drugs Register and the Riksstroke register. Individuals were grouped according to number of conditions: none (0), low (1), moderate (2–3) or high (≥4). Co-occurrence was analysed using hierarchical clustering, and multivariable analyses were used to estimate the prognostic significance of individual conditions. Results The proportion of patients without comorbidity was 24.8%; 31.8% had low comorbidity; 33.5% had moderate comorbidity and 9.9% had high comorbidity. At 12 months, the proportion of poor outcome (dead or dependent: mRS ≥3) was 24.8% (no comorbidity), 34.7% (low), 45.2% (moderate) and 59.4% (high). At five years, these proportions were 37.7%, 50.3%, 64.3%, and 81.7%, respectively. There was clustering of cardiovascular conditions and substantial negative effects of dementia, kidney, and heart failure. Conclusion Comorbidity is common and has a strong impact on mortality and functional outcome. Our results highlight the need for health systems to shift focus to a comprehensive approach in stroke care that includes multimorbidity as a key component.
Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets
Authors: Hoell Jessica I. , Ginzel Sebastian , Kuhlen Michaela , Kloetgen Andreas , Gombert Michael , Fischer Ute , Hein Daniel , Demir Salih , Stanulla Martin , Schrappe Martin , zur Stadt Udo , Bader Peter , Babor Florian , Schuster Friedhelm , Strahm Brigitte , Alten Julia , Moericke Anja , Escherich Gabriele , von Stackelberg Arend , Thiele Ralf , McHardy Alice C. , Peters Christina , Bornhauser Beat , Bourquin Jean-Pierre , Krause Stefan , Enczmann Juergen , Meyer Lüder Hinrich , Eckert Cornelia , Borkhardt Arndt , Meisel Roland 
Published: October 2019

Key Points
Pediatric ALL relapses after allogeneic stem cell transplantation display highly diverse, dynamic and patient-individual genetic lesions. Nine of 10 relapsing pediatric transplant recipients present with genetic alterations for which novel targeted therapies are available.
Role of the coagulation system in the pathogenesis of sickle cell disease
Authors: Nasimuzzaman Md , Malik Punam 
Published: October 2019

AbstractSickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and cumulative organ damage such as nephropathy, pulmonary hypertension, pathologic heart remodeling, and liver necrosis. Coagulation system activation, a conspicuous feature of SCD that causes chronic inflammation, is an important component of SCD pathophysiology. The key coagulation factor, thrombin (factor IIa [FIIa]), is both a central protease in hemostasis and thrombosis and a key modifier of inflammation. Pharmacologic or genetic reduction of circulating prothrombin in Berkeley sickle mice significantly improves survival, ameliorates vascular inflammation, and results in markedly reduced end-organ damage. Accordingly, factors both upstream and downstream of thrombin, such as the tissue factor–FX complex, fibrinogen, platelets, von Willebrand factor, FXII, high-molecular-weight kininogen, etc, also play important roles in SCD pathogenesis. In this review, we discuss the various aspects of coagulation system activation and their roles in the pathophysiology of SCD.
Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice
Authors: Shirai Toshiaki , Revenko Alexey S. , Tibbitts Justin , Ngo Anh T. P. , Mitrugno Annachiara , Healy Laura D. , Johnson Jennifer , Tucker Erik I. , Hinds Monica T. , Coussens Lisa M. , McCarty Owen J. T. , Monia Brett P. , Gruber András 
Published: October 2019

Key pointsAntisense oligonucleotide targeting of hepatic THPO gene expression reduces platelet count within the hemostatic range in mice and baboons. THPO gene silencing suppresses spontaneous metastatic mammary gland carcinoma progression in transgenic MMTV-PyMT mice.
Association between the HLA-DRB1*03:01-DQB1*02:01 haplotype and PF4/heparin antibodies
Authors: Zhang Ray , Duffy Brian F. , Lange Vinzenz , Eby Charles S. , Liu Chang 
Published: October 2019

Key Points
HLA-DRB1*03:01-DQB1*02:01 haplotype patients develop higher anti–platelet factor 4/heparin (PF4/H) levels following IV heparin exposure. HLA-restricted antigen presentation may play a role in the formation of anti-PF4/H antibodies.
Similar outcomes of alemtuzumab-based hematopoietic cell transplantation for SAA patients older or younger than 50 years
Authors: Sheth Vipul Sharad , Potter Victoria , Gandhi Shreyans A. , Kulasekararaj Austin Gladston , de Lavallade Hugues , Muus Petra , Pagliuca Antonio , Rice Carmel F. M. , Mehra Varun , Grimaldi Francesco , Inam Shafqat , Barber Linda D. , Mufti Ghulam J. , Marsh Judith C. 
Published: October 2019

Key Points
GRFS is similar between older and younger patients using FCC conditioning but comorbidities impact on outcome of SAA HSCT. Immunomodulatory B lymphocytes potentially contribute to control of alloreactivity and low GVHD after FCC HSCT.
Five-year outcomes of the S1106 study of R-hyper-CVAD vs R-bendamustine in transplant-eligible patients with mantle cell lymphoma
Authors: Kamdar Manali , Li Hongli , Chen Robert W. , Rimsza Lisa M. , Leblanc Michael L. , Fenske Timothy S. , Shea Thomas C. , Barr Paul M. , Phillips Tycel J. , Leonard John P. , Kahl Brad S. , Friedberg Jonathan W. , Smith Sonali M. 
Published: October 2019

Key Points
Five-year follow-up of S1106 demonstrates similar efficacy, MRD negativity, and 5-year survival with RH or RB, but RH was more toxic than RB. RB showed excellent efficacy and survival and less toxicity compared with a cytarabine-based regimen in transplant-eligible MCL patients.
Safety of allogeneic hematopoietic cell transplant in adults after CD19-targeted CAR T-cell therapy
Authors: Shadman Mazyar , Gauthier Jordan , Hay Kevin A. , Voutsinas Jenna M. , Milano Filippo , Li Ang , Hirayama Alexandre V. , Sorror Mohamed L. , Cherian Sindhu , Chen Xueyan , Cassaday Ryan D. , Till Brian G. , Gopal Ajay K. , Sandmaier Brenda M. , Maloney David G. , Turtle Cameron J. 
Published: October 2019

Key Points
The toxicity of allo-HCT in patients with prior CAR-T therapy was not higher than what is expected in these high-risk patients. In ALL patients, there seems to be a benefit from earlier utilization of allo-HCT after CAR-T therapy.
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia
Authors: Bejanyan Nelli , Kim Soyoung , Hebert Kyle M. , Kekre Natasha , Abdel-Azim Hisham , Ahmed Ibrahim , Aljurf Mahmoud , Badawy Sherif M. , Beitinjaneh Amer , Boelens Jaap Jan , Diaz Miguel Angel , Dvorak Christopher C. , Gadalla Shahinaz , Gajewski James , Gale Robert Peter , Ganguly Siddhartha , Gennery Andrew R. , George Biju , Gergis Usama , Gómez-Almaguer David , Vicent Marta Gonzalez , Hashem Hasan , Kamble Rammurti T. , Kasow Kimberly A. , Lazarus Hillard M. , Mathews Vikram , Orchard Paul J. , Pulsipher Michael , Ringden Olle , Schultz Kirk , Teira Pierre , Woolfrey Ann E. , Saldaña Blachy Dávila , Savani Bipin , Winiarski Jacek , Yared Jean , Weisdorf Daniel J. , Antin Joseph H. , Eapen Mary 
Published: October 2019

Key PointsFlu/Cy/ATG and Cy/ATG regimens offer the best survival for matched-sibling BMT. Transplantation in patients aged ≥30 years is associated with higher mortality after matched-sibling and unrelated donor BMT.