bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychotropic Drugs and Outcome in Patients Receiving Anticoagulant Therapy for Venous Thromboembolism
Authors: Marchena Pablo Javier , Tzoran Inna , Brenner Benjamin , Martín Mar , Malý Radovan , Bura-Riviere Alessandra , Valle Reina , Hernández-Blasco Luis , López-Sáez Juan Bosco , Monreal Manuel ,   RIETE Investigators
Published: April 2020

Abstract
Background The influence (if any) of the use of psychotropic drugs on outcome in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated.
Methods We used data from the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the risk for VTE recurrences, major bleeding, or death during the course of anticoagulant therapy, according to the use of psychotropics at baseline.
Results Among 49,007 patients with VTE enrolled from February 2009 to September 2019, total 5,230 (11%) were using psychotropics at baseline: antidepressants 3,273 (6.7%), antipsychotics 1,588 (3.2%), and anticholinesterases 369 (0.7%). During the course of anticoagulation, 1,259 patients developed VTE recurrences, 1,231 bled, and 3,988 died (fatal pulmonary embolism 269 and fatal bleeding 187). On multivariable analysis, patients using psychotropics at baseline had a similar risk for VTE recurrences (adjusted hazard ratio [HR]: 0.81; 95% confidence interval [CI]: 0.58–1.12), a nonsignificantly higher risk for major bleeding (adjusted HR: 1.15; 95% CI: 0.97–1.35), and a higher risk for intracranial bleeding (adjusted HR: 1.83; 95% CI: 1.32–2.53) or death (adjusted HR: 1.44; 95% CI: 1.32–1.57) compared with those not using psychotropics. When separately analyzed, the highest risk for intracranial bleeding was found in patients using antidepressants (adjusted HR: 1.60; 95% CI: 1.08–2.37) or antipsychotics (adjusted HR: 2.02; 95% CI: 1.17–3.49) but not in those on anticholinesterases (adjusted HR: 1.69; 95% CI: 0.62–4.60).
Conclusion During the course anticoagulation for VTE, patients using psychotropics at baseline were at increased risk for intracranial bleeding.
N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation
Authors: Hearn James I. , Green Taryn N. , Chopra Martin , Nursalim Yohanes N. S. , Ladvanszky Leandro , Knowlton Nicholas , Blenkiron Cherie , Poulsen Raewyn C. , Singleton Dean C. , Bohlander Stefan K. , Kalev-Zylinska Maggie L. 
Published: April 2020

AbstractThe release of calcium ions (Ca2+) from the endoplasmic reticulum (ER) and related store-operated calcium entry (SOCE) regulate maturation of normal megakaryocytes. The N-methyl-D-aspartate (NMDA) receptor (NMDAR) provides an additional mechanism for Ca2+ influx in megakaryocytic cells, but its role remains unclear. We created a model of NMDAR hypofunction in Meg-01 cells using CRISPR-Cas9 mediated knockout of the GRIN1 gene, which encodes an obligate, GluN1 subunit of the NMDAR. We found that compared with unmodified Meg-01 cells, Meg-01-GRIN1
−/− cells underwent atypical differentiation biased toward erythropoiesis, associated with increased basal ER stress and cell death. Resting cytoplasmic Ca2+ levels were higher in Meg-01-GRIN1
−/− cells, but ER Ca2+ release and SOCE were lower after activation. Lysosome-related organelles accumulated including immature dense granules that may have contributed an alternative source of intracellular Ca2+. Microarray analysis revealed that Meg-01-GRIN1
−/− cells had deregulated expression of transcripts involved in Ca2+ metabolism, together with a shift in the pattern of hematopoietic transcription factors toward erythropoiesis. In keeping with the observed pro-cell death phenotype induced by GRIN1 deletion, memantine (NMDAR inhibitor) increased cytotoxic effects of cytarabine in unmodified Meg-01 cells. In conclusion, NMDARs comprise an integral component of the Ca2+ regulatory network in Meg-01 cells that help balance ER stress and megakaryocytic-erythroid differentiation. We also provide the first evidence that megakaryocytic NMDARs regulate biogenesis of lysosome-related organelles, including dense granules. Our results argue that intracellular Ca2+ homeostasis may be more important for normal megakaryocytic and erythroid differentiation than currently recognized; thus, modulation may offer therapeutic opportunities.
Optimizing Postoperative Pain Control in Autologous Breast Reconstruction: A Systematic Review
Authors: Knackstedt Rebecca , Oliver Jeremie D. , Gatherwright James 
Published: April 2020

Abstract
Background Pain management approaches in autologous breast reconstruction have become a topic of great interest in the era of enhanced recovery after surgery protocols, as well as the opioid epidemic. The management of postoperative pain is of critical importance for women undergoing breast reconstruction; however, these protocols have yet to be synthesized and compared in the primary literature. Herein, we present a systematic review of approaches to provide optimal pain control while minimizing narcotic use and its associated potential negative sequelae in autologous breast reconstruction.
Methods A comprehensive systematic review of the published literature was conducted using Ovid Medline/PubMed database without timeframe limitations, in compliance with the guidelines outlined in the Preferred Reporting Items for Systematic reviews and Meta-Analyses. Inclusion criteria were selected for studies reporting objective outcomes of pain modulation in autologous breast reconstruction. Articles for inclusion were stratified based on intervention.
Results A total of 101 articles were identified on initial search query. After full-text review and final screening of all articles and review of included studies’ references, 28 studies met the inclusion criteria and were analyzed.
Conclusion There continues to be a substantial need for evidence-based guidelines in the plastic surgery literature. Mitigating postoperative pain can improve health-related quality of life, reduce health care resource utilization and costs, and minimize perioperative opiate use. Given the increasing popularity of and access to autologous approaches to breast reconstruction, we hope this area of study continues to be a top priority for plastic surgeons to allow for optimized postoperative care.
Flaxseed and Its Components in Treatment of Hyperlipidemia and Cardiovascular Disease
Authors: Prasad Kailash , Khan Amal S. , Shoker Muhammad 
Published: April 2020

AbstractThis paper describes the effects of flaxseed and its components (flax oil, secoisolariciresinoldiglucoside[SDG], flax lignan complex [FLC], and flax fibers] on serum lipids (total cholesterol [TC], low-density lipoprotein-cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides [TG]) in animals and humans. Ordinary flaxseed reduces TG, TC, LDL-C, and TC/HDL-C levels in a dose-dependent manner in animals. In humans, it reduces serum lipids in hypercholesterolemicpatients but has no effects in normocholesterolemicpatients. Flax oil has variable effects on serum lipids in normo- and hypercholesterolemic animals. Flax oil treatment, with a dosage containing greater than 25 g/day of α-linolenic acid, reduces serum lipids in humans. Although FLC reduces serum lipids and raises serum HDL-C in animals, its effects on serum lipids in humans are small and variable. Flax fibers exert small effects on serum lipids in humans. Crop Development Centre (CDC)-flaxseed, which contains low concentrations of α-linolenic acid, has significant lipid lowering effects in animals. Pure SDG has potent hypolipidemic effects and raises HDL-C. In conclusion, flaxseed and pure SDG have significant lipid-lowering effects in animals and humans, while other components of flaxseed have small and variable effects.
The complexity of human computation via a concrete model with an application to passwords
Authors: Blum Manuel , Vempala Santosh 
Published: April 2020

SignificanceThis work presents a concrete, mathematically precise model of what humans can compute in their heads. It thereby provides a method to probe the limits of human computation (can humans generate numbers that look random to a powerful computer?) as well as to design efficient humanly computable mental algorithms for everyday tasks, such as generating passwords and making real-time decisions.
Exploring the longitudinal development of grammatical complexity in the disciplinary writing of L2-English university
students
Authors: Biber Douglas , Reppen Randi , Staples Shelley , Egbert Jesse 
Published: April 2020

Abstract
The present paper employs a corpus-based approach to track the longitudinal language development of university
students. Compared to many other longitudinal studies, the present study tracks development over a relatively long period of time
(two years) for a relatively large group of students (N = 22). However, the most important difference from
previous research is that the study explores the linguistic characteristics of disciplinary writing, across levels of education
and academic disciplines, investigating the writing tasks required for disciplinary content courses over two years of university
education. We focus on grammatical complexity features associated with the hypothesized stages of development proposed in Biber et al. (2011). Methodologically, the study proposes research designs and
statistical approaches that permit investigation of longitudinal development in an unbalanced corpus of natural texts. And
linguistically, the results generally support the hypothesized stages of development, documenting a decline in the use of
dependent clause complexity features and an increase in the use of phrasal complexity features. As such, the study adds to the
growing body of research that emphasizes the importance of phrasal complexity in the development of academic writing.
Internet memes as multilayered re-contextualization vehicles in lay-political online
discourse
Authors: Kirner-Ludwig Monika 
Published: April 2020

Abstract
It is well established that the internet meme has come to represent a highly creative discursive device used to
“facilitate the […] communication of one’s own political beliefs, attitudes and orientations” (Ross and Rivers 2017: 1). Although internet memes and political internet memes in particular have been addressed to
many communicative situations such as participatory culture (e.g., Jenkins 2006; Shifman 2014; Theocharis 2015), one aspect
that has not been paid enough attention to concerns the forms in which users refer to individual political figures and events in
political memes. This being said, the present paper focuses on referring strategies (see Kirner-Ludwig and Zimmermann 2015; Kirner-Ludwig 2020) as employed in
political internet memes on Reddit, including direct and indirect quotes, citations and allusions. A specific focus is going to be
on such political internet memes that employ pop cultural and telecinematic reference points and recontextualize them from their
original into new target contexts (see Bublitz 2015; Gruber 2019). As shall be shown, practices such as combining constructed speech elements into
recontextualized elements in political internet memes create multiple intertextual references that may enhance visibility,
saliency and, thus, the ‘lifetime’ of a political meme.
Fe dopants and surface adatoms versus nontrivial topology of single-crystalline Bi2Se3
Authors: Chrobak M , Maćkosz K , Jurczyszyn M , Dobrzański M , Nowak K , Ślęzak T , Zając M , Sikora M , Rams M , Eelbo T , Stępień J , Waśniowska M , Mathon O , Yakhou-Harris F , Merkel D G , Miotkowski I , Kąkol Z , Kozłowski A , Przybylski M , Tarnawski Z 
Published: April 2020

Abstract
Both preserved gapless states and gapping of Dirac states due to broken time reversal symmetry in bismuth chalcogenide topological insulators with surface and bulk magnetic impurities have been observed and reported in the literature. In order to shed more light on the mechanism of such effects we have performed comprehensive element selective study of the impact of Fe impurity position in the Bi2Se3 lattice on its magnetism. The iron atoms were imbedded in the structure (volume dopants) or deposited on the surface (adatoms) and they revealed striking phenomena. Volume doping preserves non-trivial topology of Bi1.98Fe0.02Se3. Fe atoms not only substitute Bi, but also locate in van der Waals gap. The former are magnetically isotropic, while the latter reveal large magnetic moment (4.5 μ
B) with perpendicular anisotropy if located near the surface. Majority of Fe adatoms on the surface of Bi2Se3 exhibit weaker moment (3.5 μ
B) with in-plane anisotropy, as expected for non-interacting species. Negligible interaction between surface electronic states and magnetic adatoms is confirmed by identical vibration spectra of Fe deposited on TI surface of Bi2Se3 and non-TI surface of Bi2S3. The data gathered show how indispensable is the knowledge of the magnetic impurity distribution for applications of bismuth chalcogenide systems.
About the foundation of the Kubo generalized cumulants theory: a revisited and corrected approach
Authors: Bianucci Marco , Bologna Mauro 
Published: April 2020

Abstract
More than fifty years ago, in a couple of seminal works (Kubo 1962 J. Phys. Soc. Japan
17 1100–20; Kubo 1963 J. Math. Phys. 4 174–83) Kubo introduced the important idea of generalized cumulants, extending to stochastic operators this concept implicitly introduced by Laplace in 1810. Kubo’s idea has been applied in several branches of physics, where the result of the average process is a Lioville operator or an effective time evolution operator for the density matrix of spin systems or the reduced density matrix for boson-fermions etc. Despite this success, the theoretical developments in these Kubo works pose problems that were highlighted many years ago by Fox and van Kampen and never solved. These weaknesses and errors, in particular concerning the factorization property of exponentials of cumulants and the explicit expressions that give generalized cumulants in terms of generalized moments and vice-versa, caused some perplexity (and confusion) about the possible application of this procedure, limiting its use, in practice. In the present paper, we give a sound ground to the approach to cumulant operators, working in a general framework that shows the potentiality of the old Kubo idea, today not yet fully exploited. It results that, for the same moment operators, different definitions of generalized cumulants can be adopted. A general Kubo–Meeron closed-form formula giving cumulant operators in terms of moment operators cannot be obtained, but the reverse one, cumulants in terms of operators, is given and, noticeably, formally it does not depend on the specific nature of the moments, but just on the definition of the generalized cumulants.
Quantifying the uncertainty introduced by internal climate variability in projections of Canadian crop production
Authors: Qian Budong , Jing Qi , Smith Ward , Grant Brian , Cannon Alex J , Zhang Xuebin 
Published: April 2020

Abstract
Internal climate variability (ICV) is one of the major sources of uncertainty in climate projections, yet it is seldom quantified for projections of crop production. Our study focuses on quantifying the uncertainty due to ICV in projections of crop productions in Canada. We utilize climate scenarios from two large ensembles (LEs, CanESM2-LE and CanRCM4-LE with 25 members each) as inputs to the crop models in the Decision Support System for Agrotechnology Transfer. We simulate crop yields for canola, maize and spring wheat under the future climates of four global warming levels. The coefficient of variation (CV) of the projected crop production across the LE members is used to quantify the uncertainty related to ICV and this is compared with the CVs generated using the 20 GCMs in the Coupled Model Intercomparison Project Phase 5 (CMIP5). Crop production in Canada could increase with global warming, e.g. spring wheat production could increase by up to 21% at the warming level of 3.0 °C. The projections often produce larger uncertainty associated with the GCMs than from ICV at all warming levels above 2.0 °C. The results from an asymptotic test for the equality of CVs show a significant difference in CVs of projections of canola production between CanESM2-LE/CanRCM4-LE and CMIP5 for the warming level of 3.0 °C. However, the test results do not indicate a significant difference among the ensembles at all four warming levels for maize and spring wheat. The uncertainty due to ICV is often comparable to that associated with GCMs at the warming level of 1.5 °C, e.g. a CV of 6.0 and 6.4% for CanESM2-LE and CanRCM4-LE and 6.6% for CMIP5 in the projections of spring wheat production. We conclude there is a need to account for uncertainty related to ICV in projections of Canadian crop production, especially at lower warming levels.
Stationary state degeneracy of open quantum systems with non-abelian symmetries
Authors: Zhang Zh , Tindall J , Mur-Petit J , Jaksch D , Buča B 
Published: April 2020

Abstract
We study the null space degeneracy of open quantum systems with multiple non-abelian, strong symmetries. By decomposing the Hilbert space representation of these symmetries into an irreducible representation involving the direct sum of multiple, commuting, invariant subspaces we derive a tight lower bound for the stationary state degeneracy. We apply these results within the context of open quantum many-body systems, presenting three illustrative examples: a fully-connected quantum network, the XXX Heisenberg model and the Hubbard model. We find that the derived bound, which scales at least cubically in the system size the SU(2) symmetric cases, is often saturated. Moreover, our work provides a theory for the systematic block-decomposition of a Liouvillian with non-abelian symmetries, reducing the computational difficulty involved in diagonalising these objects and exposing a natural, physical structure to the steady states—which we observe in our examples.
Neural networks and kernel ridge regression for excited states dynamics of CH2NH 2+ : From single-state to multi-state representations and multi-property machine learning models
Authors: Westermayr Julia , Faber Felix A , Christensen Anders S , von Lilienfeld O Anatole , Marquetand Philipp 
Published: April 2020

AbstractExcited-state dynamics simulations are a powerful tool to investigate photo-induced reactions of molecules and materials and provide complementary information to experiments. Since the applicability of these simulation techniques is limited by the costs of the underlying electronic structure calculations, we develop and assess different machine learning models for this task. The machine learning models are trained onab initiocalculations for excited electronic states, using the methylenimmonium cation (CH2NH2+) as a model system. Two distinct strategies for modeling excited state properties are tested in this work. The first strategy is to treat each state separately in a kernel ridge regression model and all states together in a multiclass neural network. The second strategy is to instead encode the state as input into the model, which is tested with both models. Numerical evidence suggests that using the state as input yields the best performance. An important goal for excited-state machine learning models is their use in dynamics simulations, which needs not only state-specific information but also couplings, i.e. properties involving pairs of states. Accordingly, we investigate how well machine learning models can predict the couplings. Furthermore, we explore how combining all properties in a single neural network affects the accuracy. Finally, machine learning predicted energies, forces, and couplings are used to carry out excited-state dynamics simulations. Results demonstrate the scopes and possibilities of machine learning to model excited-state properties.
Data-Driven Development of an Institutional “Gross-Only” Policy for the Examination of Select Surgical Pathology Specimens
Authors: Arispe Angulo Karen R , Farooq Ayesha , Samra Hasan , Weldemichael Wegahta , Anderson Jennifer , Jorns Julie M 
Published: April 2020

AbstractObjectivesTo determine diagnostic, workflow, and economic implications of instituting a gross-only policy at our institution.MethodsRetrospective (2017) key word searches were performed to identify “gross-only” cases for which microscopic evaluation could potentially be omitted, but was performed, and those who underwent gross evaluation per surgeon request. Cases were evaluated for type(s), part(s), block volume, turnaround time, demographics, and diagnosis. Laboratory costs and reimbursement were evaluated.ResultsIn total, 448 potential gross-only cases with 472 specimens consisted of atherosclerotic plaques (33.5%), bariatric stomach/bowel (32.6%), hernia (15.7%), heart valves (12.7%), and other (5.9%). Four (2.6%) bariatric surgery cases had Helicobacter pylori infection; these were the only cases with “significant” histologic findings. Cost analysis revealed that converting all potential gross-only specimens to gross only would result in overall losses based on average reimbursements, most influenced by bariatric specimens (Current Procedural Terminology code 88307), comprising 65.2% of estimated loss.ConclusionsEstablishing a gross-only policy should be guided by established recommendations but institutionally individualized and data driven. It was reasonable for us to establish a gross-only policy for most evaluated specimens, while excluding bariatric stomach specimens in which microscopic pathology could be missed, given the lack of H pylori screening at our institution.
Phigaro: high-throughput prophage sequence annotation
Authors: Starikova Elizaveta V , Tikhonova Polina O , Prianichnikov Nikita A , Rands Chris M , Zdobnov Evgeny M , Ilina Elena N , Govorun Vadim M 
Published: April 2020

Abstract

Summary
Phigaro is a standalone command-line application that is able to detect prophage regions taking raw genome and metagenome assemblies as an input. It also produces dynamic annotated ‘prophage genome maps’ and marks possible transposon insertion spots inside prophages. It is applicable for mining prophage regions from large metagenomic datasets.

Availability and implementation
Source code for Phigaro is freely available for download at https://github.com/bobeobibo/phigaro along with test data. The code is written in Python.

Supplementary information
Supplementary data are available at Bioinformatics online.
Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice†
Authors: Miao Xiaosu , Sun Tieqi , Barletta Holly , Mager Jesse , Cui Wei 
Published: April 2020

Abstract
Retinoblastoma-binding protein 4 (RBBP4) (also known as chromatin-remodeling factor RBAP48) is an evolutionarily conserved protein that has been involved in various biological processes. Although a variety of functions have been attributed to RBBP4 in vitro, mammalian RBBP4 has not been studied in vivo. Here we report that RBBP4 is essential during early mouse embryo development. Although Rbbp4 mutant embryos exhibit normal morphology at E3.5 blastocyst stage, they cannot be recovered at E7.5 early post-gastrulation stage, suggesting an implantation failure. Outgrowth (OG) assays reveal that mutant blastocysts cannot hatch from the zona or can hatch but then arrest without further development. We find that while there is no change in proliferation or levels of reactive oxygen species, both apoptosis and histone acetylation are significantly increased in mutant blastocysts. Analysis of lineage specification reveals that while the trophoblast is properly specified, both epiblast and primitive endoderm lineages are compromised with severe reductions in cell number and/or specification. In summary, these findings demonstrate the essential role of RBBP4 during early mammalian embryogenesis.