bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auf den Spuren Theodor Fontanes in Sachsen-Anhalt
Authors: Göring H.-D. 
Published: September 2020

ZusammenfassungTheodor Fontane hat die Region des heutigen Bundeslandes Sachsen-Anhalt in den Jahren 1840, 1848, 1868 und zwischen 1877 und 1884 mehrmals besucht. Zunächst war er kurzzeitig in einer Apotheke in Burg bei Magdeburg als Apothekergehilfe tätig, spätere Aufenthalte, v. a. im Harz, dienten der Erholung und schriftstellerischer Arbeit. Fontane wurde durch seine Aufenthalte in der Region zu einigen seiner Romane inspiriert. Historische Personen und Orte in Sachsen-Anhalt wurden zu Schauplätzen und realen Vorbildern für die Protagonisten seiner Romane „Vor dem Sturm“, „Cecile“, „Ellerklipp“, „Grete Minde“ und „Effi Briest“.
Idiopathic Hypoparathyroidism: Still a Diagnostic Conundrum –
A Tertiary Centre Experience
Authors: Jain Rujul , Singh S. K. , Agrawal N. K. 
Published: September 2020

AbstractIdiopathic hypoparathyroidism leads to hypocalcemia and hyperphosphatasemia and
usually has a genetic aetiology. The variable but often subtle signs and
symptoms usually lead to a misdiagnosis of hypoparathyroidism. Case records of
32 patients of idiopathic hypoparathyroidism admitted over a period of five
years were analysed. There was a lag period of 5.94 years from the onset of
symptoms to the diagnosis. Carpopedal spasm was the most common indication for
admission to the hospital. Trivial symptoms such as fatigue (84%) and
paresthesia (62.5%) were the most common reported symptoms. A sum of
46.5% of the patients were on antiepileptic drugs before the correct
diagnosis of hypoparathyroidism was made. This observation emphasized that
Calcium profile should be obtained in patients with history of paresthesia and
seizure to avoid the long delay in diagnosis of hypoparathyroidism.
Associations of the LPL S447X and Hind III Polymorphism with Type 2 Diabetes Mellitus Risk: A Meta-Analysis
Authors: Liu Na , Sang Yan , Chen Shengzhi , Liu Xiaoming 
Published: September 2020

AbstractThe present study was aimed to evaluate the association of lipoprotein lipase (LPL) gene (S447X and Hind III) polymorphisms and T2DM. Relevant studies were identified through systematic search PubMed, Cochrane Library, Embase, Wanfang, CNKI databases. A total of 22 studies (8 studies for LPL S447X and 14 studies for Hind III) were included. The results showed that the LPL S447X polymorphism was associated with the low risk of T2DM under dominant and allelic genetic models. Subgroup analysis by ethnicity showed that the LPL S447X polymorphism was associated with a decreased risk of T2DM in the Asian population (under dominant, heterozygous and allelic genetic models). In addition, we found that X allele carriers of S447X polymorphism is associated with low levels of TC, TG, and LDL. In subgroup analysis, Hind III polymorphism was associated with low risk of T2DM in Asian populations (under dominant, heterozygote, allele genetic models). Moreover, the carriers of H allele of Hind III have lower levels of TG, and higher levels of HDL-C. This meta-analysis demonstrated that 447X carriers and H allele in LPL gene associated with low risk of T2DM, which may due to in part to the change of serum level of TC, TG, LDL, and HDL.
Induction of Cell Cycle Arrest in MKN45 Cells after Schiff Base Oxovanadium Complex Treatment Using Changes in Gene Expression of CdC25 and P53
Authors: Mirjalili Sara , Dejamfekr Maedeh , Moshtaghian Abdolvahab , Salehi Mehdi , Behzad Mahdi , Khaleghian Ali 
Published: September 2020

AbstractCompounds containing heavy metals such as vanadium, nickel, and cobalt may be useful for the treatment of various diseases. Multiple studies have been carried out on the anticancer effects of vanadium-contained compounds on different cell types. This study aimed to evaluate the role of schiff base oxovanadium complex ([N,N'-bis(3-methoxy-salicylidene)-1,2-phenylenediamine]Vanadium(IV) Oxide Complex) on cell cycle arrest and different cell cycle phases in MKN45 cell of gastric cancer. Schiff base oxovanadium complex was used to assessthe amount of cytotoxicity via cell viability test. PI color and flow cytometry technique were applied to evaluate the effects of vanadium synthetic compounds on cell cycle phases; subsequently, we analyzed the change rates of gene expression in P53, GADD45, and CDC25 genes, which are involved in cell division phases. The findings indicated that the vital activities of time-dependent and concentration-dependent MKN45 cells with schiff base oxovanadium complex were significantly reduced; therefore, this complex is able to inhibit the migration of cancer cells and metastatic activities in a time-dependent mode. Cell cycle arrest was obtained after 48 h of treatment in phase G2/M at 1 microgram/milliliter (μg/ml) concentration. This is probably attributed to the increased gene expression of P53 and GADD45 genes and reduced gene expression of CDC25 gene. Compounds containing such heavy metals as vanadium decrease the growth, proliferation, and migration of MKN45 cells. They arrest cell cycle in phase G2/M via changing the controllers of cell division phases activated due to DNA damage.
Expedient Approach to the Synthesis of Betrixaban
Authors: Raji Reddy Chada , Sinare Sudam N. 
Published: September 2020

AbstractA new scalable route to synthesize the factor Xa (FXa) inhibitor betrixaban is disclosed. The product is obtained in a seven-step reaction sequence (in five stages using two one-pot reactions) starting from easily accessible 4-(N,N-dimethylcarbamimidoyl)benzoate. Effective isolation of intermediates, use of cost-effective amide formation and 2-methyltetrahydrofuran as an effective reaction solvent as well as for extraction in three of the stages, are key features. The strategy provides the desired product in 38% overall yield with high purity (>98%).
Outcome of Free Diced Cartilage Grafts in Rhinoplasty: A Systematic Review
Authors: Ledo Taynara Oliveira , Ramos Helena Hotz Arroyo , Buba Cibele Madsen , Webster Guilherme , de Lima Jr Jesse Teixeira , de Paiva Diógenes Lopes , Jurado José 
Published: September 2020

AbstractDiced cartilage grafts are used to increase and refine the nasal contour, providing easy molding and versatility when compared with block grafts. However, all grafts present the possibility of visibility, distortion, and absorption. The aim of this study is to evaluate, through a systematic review, the outcome of the use of the free diced graft cartilage in rhinoplasty. A systematic search of the literature was performed in the databases (PubMed, Lilacs, Scielo, Cochrane) with the terms “diced cartilage” and “rhinoplasty.” Studies were selected according to the inclusion and exclusion criteria and data extracted and grouped for analysis. Six eligible studies were included. In total, 4,044 patients underwent rhinoplasty with free diced cartilage graft, with 61 (1.51%) of them requiring reoperation. The main reasons were overcorrection and irregularities of the nasal dorsum. The infection rate was reported in three studies, with 2 (0.06%) of 3,252 patients presenting infection at the graft site. Two cases of displacement were treated with external molding, without reoperation. The graft resorption was reported in four articles, which described 22 (0.67%) cases of partial resorption in 3,288 patients. Therefore, the available evidence suggests that resorption of the graft and unfavorable outcomes are rare.
An Evaluation of the Learning Curve in Pulmonary Endarterectomy Using Propensity Score Matching
Authors: Miyahara Shunsuke , Schröder Tom A. , Wilkens Heinrike , Karliova Irem , Langer Frank , Kunihara Takashi , Schäfers Hans-Joachim 
Published: September 2020

Abstract
Objective Pulmonary endarterectomy (PEA) is the only causative, but demanding treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH). We analyzed our results with PEA to evaluate the learning curve.
Methods Consecutive 499 patients who underwent PEA between 1995 and 2014 were divided into two groups according to the temporal order: early cohort (n = 200, December 1995–March 2006), and late cohort (n = 299, March 2006–December 2014). We assessed perioperative outcomes after PEA as compared between the early and the late cohort also in propensity-score–matched cohorts.
Results Age at the surgery was older in the late cohort (p = 0.042). Preoperative mean pulmonary artery pressure (mPAP) was 46.8 ± 11.0 mm Hg in the early cohort and 43.5 ± 112.7 mm Hg in the late cohort (p = 0.0035). The in-hospital mortality in the early and late cohorts was 14.0% (28/200) and 4.7% (14/299), respectively (p = 0.00030). The duration of circulatory arrest (CA) became much shorter in the late cohort (42.0 ± 20.5 min in the early and 24.2 ± 11.6 min in the late cohort, respectively, p < .0001). In matched cohorts, the in-hospital mortality showed no significant difference (8.7% in the early cohort and 5.2% in the late cohort, < 0.0001). The CA duration, however, was still shorter in the late cohort (p <0.0001).
Conclusions Over time, older patients have been accepted for surgery, more patients were operated for lesser severity of CTEPH. Duration of CA and mortality decreased even beyond the first 200 patients, indicating a long learning curve.
A Multidisciplinary Management Framework for the Treatment of Benign Prostatic Hyperplasia with Focus on Homoeopathy: A Review
Authors: Karso Liyi 
Published: September 2020

Abstract
Background Benign prostatic hyperplasia (BPH) is a globally prevailing urological condition among ageing men. In India, a few epidemiological studies conducted on BPH patients suggest it as the most common pathological condition with an incidence of around 93.3%. Although non-malignant, the condition adversely impacts the quality of life (QoL) in a way similar to that of other non-communicable diseases like diabetes, hypertension and cardiovascular diseases.
Objective This article aims to review the comprehensive management of BPH with focus on homoeopathic treatment.
Methods PubMed, EMBASE, Google Scholar, AYUSH PORTAL and leading homoeopathic journals were searched for articles on BPH and its homoeopathic management.
Results The review offers a holistic framework for management of BPH that is inclusive of modifiable lifestyle factors alongside homoeopathic treatments. It further underscores that the condition may be cost-effectively managed through homoeopathy to bring about better QoL among people with BPH.
Conclusion Lifestyle optimisation and management of metabolic risk factors may reduce the progression of BPH. Homoeopathic medicines are not only useful in effective management of BPH but also cost-effective, safe and non-surgical. However, randomised controlled trials and double-blind studies can be further taken up in future for more precise authentication.
Iron Deficiency Anemia and Serum Hepcidin Level in Children with Typhoid Fever: A Case–Control Study
Authors: Mohamed Ghada , Aboelhassan Samir , Zaki Maysaa El Sayed , Wahba Yahya 
Published: September 2020

Abstract
Objective Typhoid fever is a common systemic bacterial infection in children with a complex interplay between serum hepcidin and iron. We investigated the relationship between iron deficiency anemia (IDA) and serum hepcidin level in children with acute typhoid fever.
Methods We conducted a preliminary case–control study in Mansoura University Children's Hospital, Egypt from April 2017 to May 2019 including 30 children aged 5 to 15 years with confirmed acute typhoid fever. We recruited 15 healthy nonanemic children, of comparable ages and sex as controls from the same hospital while attending for nonfebrile complaints. Typhoid fever cases were subdivided according to IDA existence into 16 cases with IDA and 14 non-IDA cases. We excluded all children having diseases which may affect serum iron and hepcidin levels, for example, liver, blood, gastrointestinal, and kidney diseases, and patients receiving drugs interfering with iron metabolism. All participants were subjected to complete blood count, serum ferritin, iron, hepcidin levels, and total iron-binding capacity (TIBC).
Results In non-IDA typhoid fever group, serum iron level was significantly low, while serum hepcidin level was significantly high when compared with controls (p < 0.001 and p = 0.02, respectively). In IDA typhoid fever group, no statistically significant difference existed as regards serum hepcidin level when compared with controls (p = 0.53). No significant correlations were detected between serum hepcidin levels and hemoglobin, serum iron, ferritin, and TIBC values in each group.
Conclusion Preexisting iron status could affect serum hepcidin level in patients with acute typhoid fever. Coexistence of IDA might oppose the up-regulatory effect of acute typhoid fever on serum hepcidin level.
Detrimental Results of COVID-19 Fear to Child Health
Authors: Yazici Mutlu Uysal , Akkaya Bilge , Torun Emine Gulsah , Azapagasi Ebru , Senel Saliha 
Published: September 2020

AbstractThe outbreak of coronavirus disease 2019 (COVID-19) and its consequences have led to fear and anxiety among individuals worldwide. The risk of coronavirus transmission frightens people more than any other health problem they face. Parents have concerns about being infected with COVID-19 and delay accessing hospitals even in an emergency which can be very detrimental to child health. Here, in this article, we would like to present eight patients delayed in admission to the hospital to draw attention to the harmful consequences of COVID-19 fear in the community. Although anxiety and fear are encouraging to take necessary precautions, exaggeration of these emotions may cause greater health problems.
Simultaneous Use of Two Different Tools to Assess Compliance with Antiepileptic Drugs: Experience in A Community-Based Study
Authors: Singh Paramjit , Gupta Kanchan , Singh Gagandeep , Kaushal Sandeep 
Published: September 2020

Abstract

Objective Antiepileptic drug (AED) therapy remains the primary form of treatment for epilepsy, noncompliance to which can result in breakthrough seizure, emergency department visits, fractures, head injuries, and increased mortality. Various tools like self-report measures, pill-counts, medication refills, and frequency of seizures can assess compliance with varying extent. Thus, assessment of compliance with AEDs is crucial to be studied.

Materials and Methods Compliance was assessed using pill-count and Morisky medication adherence scale (MMAS) during home visits. A pill-count (pills dispensed–pills remaining)/(pills to be consumed between two visits) value of 0.85 to ≤1.15 was recorded as appropriate compliance. Underdose (<0.85) and overdose (>1.15) was labeled as noncompliance. Score of 1 was given to each positive answer in MMAS. Score of ≥1 was labeled as noncompliance.
Statistical analysis: Relationship of demographic factors between compliant and noncompliant patients was analyzed using Chi-square test (SPSS version 21.0, IBM). Rest of the data was analyzed with the help of descriptive statistics using Microsoft Excel. p< 0.05 was considered statistically significant.

Results Out of 105 patients, 54 patients were noncompliant with both pill-count and MMAS. 10 patients were noncompliant with pill-count only, while 10 were noncompliant with MMAS.

Conclusion Both tools complement each other when used in combination, as use of a single tool was not able to completely detect compliance.
Acquisition of null objects in Mandarin Chinese by heritage speakers
Authors: Chou Chao-Ting Tim , Chen Tsung-Ying , Pires Acrisio 
Published: September 2020

AbstractThe acquisition of the grammatical knowledge related to inflectional morphology and syntax-pragmatics interface have both been shown to be challenging for heritage speakers (e.g.,Montrul et al. 2008;Polinsky 2006,2008;Sorace et al. 2009;Montrul 2009;Benmamoun et al. 2013a;Laleko & Polinsky 2016). In these previous work on heritage language acquisition, the acquisition of inflectional morphology (e.g. either agreement morphology or topic marking) is also a relevant acquisition task associated with the syntax-discourse phenomena under investigation. In this paper we focus on the acquisition of discourse-conditioned structures by heritage speakers when inflectional morphology is not part of the learning task. Specifically, we report results of a picture-verification experiment focusing on English-dominant heritage Chinese speakers’ grammatical knowledge of null objects. As a topic-prominent language lacking verbal tense/agreement morphology, the licensing and identification of null arguments in Chinese has nothing to do with agreement morphology. In addition, unlike other topic-prominent pro-drop languages, Chinese has no inflectional morphology associated with grammatical subjects/objects and topic phrases. Without the interference of co-occurring inflectional morphology, we found that there is no significant difference between heritage Chinese speakers and the monolingual baseline in their acceptance of null objects in contextually appropriate contexts. The results of our study cast doubt on the thesis that heritage speakers are unable to acquire discourse-related knowledge (cf.Sorace & Serratrice 2009;Laleko 2010;Laleko & Polinsky 2016) and supportYuan’s (2010)claim that interface categories should not be considered holistically.
Narratives as discursive practices in interviews
Authors: Perrino Sabina 
Published: September 2020

AbstractHumans are prone to tell stories when they interact with each other. Knowing how many stories we tell in a day could be a difficult endeavor, especially because what counts as “a story” varies across disciplines and cultures. Narratives have always been primary modes in human communication and engagement across cultures, however, and have been used as key analytical tools across numerous disciplines in the social sciences and beyond. While defining narratives has been a daunting task in narratological studies, it is important to appreciate that narratives have also been studied for their pragmatic effects in the here-and-now of speech participants’ interactions and across various spatiotemporal configurations. Through an analysis of a set of narrative practices that I collected in Senegal (West Africa) and in Northern Italy in interview settings, I demonstrate that narratives are also performative interactional events in which their sociocultural surrounding is always fluid and can influence the story in unpredictable ways as it unfolds in interaction.
Síandhocin the history of Catalan
Authors: Pujol i Campeny Afra 
Published: September 2020

AbstractOld Catalan presents two affirmative particles competing for the same function between the 13th and the 17th centuries:síandhoc. This article explores their syntax and the factors that contributed to the rise of the former and the disappearance of the latter and accounts for their distribution in the written record. Traditionally, it was believed thathocwas the only positive sentential proform active in the language until the 15th century. However,síhad already been grammaticalised as such by the 13th century, its new function being obscured in the written record by the pervasive use of the official koine established by the Crown of Aragon’sCancelleriain learned prose. Nevertheless, in documents closer to speech,símakes a much earlier appearance and shows great vitality before the 15th century, the last century whenhocwas still hegemonic before finally disappearing as a consequence of external and internal factors.
Quantum effects across dynamical horizons
Authors: Giavoni Cecilia , Schneider Marc 
Published: September 2020

Abstract
We present a generalization of the Hawking effect for dynamical trapping horizons by calculating the tunneling rate in the Hamilton–Jacobi formalism. It turns out that all horizons classified by Hayward are subjected to thermal quantum effects. While the Hawking effect for future outer and past inner trapping horizons is given as a particle emission, we show that the Hawking effect for future inner and past outer trapping horizons translates to an absorption. The universality of the treatment allows a natural transfer to the static case.
Quasi-normal mode of a regular Schwarzschild black hole
Authors: Villani Mattia 
Published: September 2020

Abstract
Some quantum gravity theories, like loop quantum gravity, predict that quantum mechanical effects will avoid the formation of a singularity inside a black hole. From the general relativity point of view, this means that the metric will differ from the ones of Schwarzschild or Kerr at least inside the event horizon. If the metric is not that of Schwarzschild or Kerr, the potential of the Regge–Wheeler equation is modified, therefore it is possible to peek inside a black hole using the quasi-normal modes to find out if there is indeed a singularity. We address this problem for a regular Schwartzchild black hole using an effective metric first introduced by Hayward.
Josephson AC effect induced by weak gravitational field
Authors: Ummarino Giovanni Alberto , Gallerati Antonio 
Published: September 2020

Abstract
In this paper we examine the possibility of a Josephson AC effect between two superconductors induced by the Earth’s gravitational field, making use of the gravito-Maxwell formalism. The theoretical framework exploits the symmetry between the weak field expansion of the gravitational field and the standard Maxwell formulation, combined with the Josephson junction physics. We also suggest a suitable experimental setup, analysing also the related possible difficulties in measurements.
Impact dynamics for gravity-driven motion of a particle
Authors: Villegas Cesar E P , Rojas Wudmir Y , Bravo Carlos , Rocha Alexandre R 
Published: September 2020

Abstract
Introductory mechanics courses use the bouncing ball model to familiarize students with the principles of binary inelastic collisions. Nonetheless, in undergraduate courses, the modeling of binary systems typically disregards the time of contact and the effects of gravity, which yields to a constant coefficient of restitution (COR) and, as a consequence, prevents students from elucidating the real dependence of COR with impact speed. In this work, we proposed a simple experimental setup to investigate the impact dynamics of a spring-mass body that bounces on a rigid plate as well as a theoretical framework that captures the velocity dependence of the COR for low-impact speeds. Our analytical expression for the COR highlights the role-played by gravity, impact speed and collision time on the collision dynamics. Our results suggest that the inclusion of gravity force allows an adequate estimation of the critical impact speed and maximum deformation distance, crucial parameters to differentiate between repulsive and attractive interaction regimes. Our experimental setup enables the clarification of several key concepts of mechanics while it is easy to be performed in most undergraduate laboratories.