bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with Covid-19 pneumonia
Authors: De Biasi Sara , Meschiari Marianna , Gibellini Lara , Bellinazzi Caterina , Borella Rebecca , Fidanza Lucia , Tartaro Domenico Lo , Mattioli Marco , Paolini Annamaria , Menozzi Marianna , Milić Jovana , Franceschi Giacomo , Fantini Riccardo , Tonelli Roberto , Sita Marco , Sarti Mario , Clini Enrico , Girardis Massimo , Guaraldi Giovanni , Mussini Cristina , Cossarizza Andrea 
Published: April 2020

Abstract
We have deeply investigated T cell compartment, plasma cytokines and cells producing cytokines in patients affected by Covid-19. At admission, patients were lymphopenic; in all of them SARS-CoV-2 was detected in a nasopharyngeal swab specimen by real-time RT-PCR, and pneumonia was subsequently confirmed by X-rays.Detailed 18-parameter flow cytometry was performed in 21 patients and 13 controls. Coupling polychromatic cytometry with unsupervised data analysis, we found that patients show an increased amount of CD4+ T lymphocytes that were activated, exhausted, stem memory or Treg. Similar results concerning activation and exhaustion were found in the CD8+ T cell compartment, within which the differences were even greater.Measuring plasma level of 31 cytokines linked to inflammation revealed that Covid-19 showed a dramatic increase of several molecules, such as TH1 and TH2 cytokines, chemokines, galectins, pro- and anti-inflammatory mediators, confirming the importance of a massive immune activation causing the cytokine storm. Then, intracellular staining detecting the simultaneous production of different cytokines after a para-physiologic stimulus given by anti-CD3/CD28 mAbs revealed not only a high capacity to produce a variety of molecules, including TNF-a, IFN-g and IL-2, but also a significant skewing of CD4+ T cells towards the TH17 phenotype.A therapeutic approach now exists based on the administration of drugs that block IL-6 pathway, and is now consistently improving the course of the disease. IL-17 is crucial in recruiting and activating neutrophils, cells that can migrate to the lung and are heavily involved in the pathogenesis of Covid-19. We show here that a significant skewing of activated T cells towards TH17 functional phenotype exists in Covid-19 patients. Thus, we suggest that blocking IL-17 pathway by already available biological drugs that are used to treat different pathologies could be a novel, additional strategy to improve the health of patients infected by SARS-CoV-2.
Bioelectrochemically-assisted nitrogen removal in osmotic membrane bioreactor
Authors: Wu You , Cai Yun , Lu Yu-Xiang , Zhang Li-Min , Yang Xiao-Li , Song Hai-Liang , Yang Yu-Li 
Published: April 2020

AbstractNitrogen removal in osmosis membrane bioreactor (OMBR) is important to its applications but remains a challenge. In this study, a bioelectrochemically-assisted (BEA) operation was integrated into the feed side of OMBRs to enhance nitrogen removal, and sodium acetate was served as a draw solute and supplementary carbon source for the growth of denitrifying bacteria due to reversed-solute. The effects of operation mode and influent ammonium (NH4+) concentration were systematically examined. Compared to a conventional OMBR, the integrated BEA-OMBR achieved higher total nitrogen removal efficiency of 98.13%, and chemical oxygen demand removal efficiency of 95.83% with the influent NH4+-N concentration of 39 mg L−1. The sequencing analyses revealed that ammonia-oxidizing bacteria (0–0.04%), nitrite-oxidizing bacteria (0–0.16%), and denitrifying bacteria (1.98–8.65%) were in abundance of the microbial community in the feed/anode side of integrated BEA-OMBR, and thus BEA operation increased the diversity of the microbial community in OMBR. Future research will focus on improving nitrogen removal from a high ammonium strength wastewater by looping anolyte effluent to the cathode. These findings have demonstrated that BEA operation can be an effective approach to improve nitrogen removal in OMBRs toward sustainable wastewater treatment.
Componentes de cambio y economía regional: El sector manufacturero en el estado de Baja California y en el municipio de Mexicali (1985-1988)
Authors: Sánchez Soler Ma. Dolores , Ortega Villa Guadalupe , Montoya Sánchez Edna E. 
Published: April 2020

Este trabajo se realizó con dos propósitos: el primero es comparar los cambios manifestados en la estructura del empleo manufacturero durante el período de 1985-1988, en el municipio de Mexicali, en relación con el estado de Baja California y el país en su conjunto; para ello se hace uso de la técnica de cambio y participación (shift & share) utilizando la información de los censos económicos: El segundo, relacionado con el anterior, se refiere a la aplicación de las tres versiones de dicha técnica a fin de determinar cuál de éstas presenta mayores elementos para la descripción de los cambios observados. El trabajo muestra que la entidad presenta ventajas de localización en las actividades de manufactura de productos metálicos, maquinaria y equipos e instrumentos quirúrgicos y de precisión; mientras que en Mexicali se registran ventajas para las actividades de papel y productos de papel y productos minerales no metálicos, aun cuando no se reporta especialización.Finalmente, se concluye que el modelo síntesis, presentado por Bishop y Simpson, es el que aporta mayores elementos para la descripción.
Evaluation of School-based Educational Intervention to Improve Knowledge and Attitude of Adolescent Girls about Puberty Health
Authors: Khodakarami Batoul , Refaei Mansoureh , Faradmal Javad , Uraki Hakime 
Published: April 2020

Background:
Awareness of pubertal issues has a great influence on the ability of girls to
cope with cognitive, social and physical changes that occur during puberty.

Objective:
The aim of this study was the evaluation of a school-based educational intervention to
improve the knowledge and attitude of adolescent girls about puberty health.

Methods:
This randomized clinical trial (Registration number: IRCT 2013111715341N2) was conducted
in Hamadan during the period of 2014-2015. Four hundred forty-six (446) adolescent female
students were recruited randomly, using a multistage sampling method. Students were randomly
assigned to three (3) groups. Group 1(educating to students) and group 2(educating to mothers)
received two 90 minutes’ puberty health educational sessions by a midwife; group 3 did not receive
any intervention. Girls' knowledge and attitude about puberty health were assessed using a questionnaire
administered to each group before and after the intervention. SPSS 16 software was used
for analyzing data.

Results:
The three groups were similar in terms of demographic characteristics. There was no significant
difference in knowledge and attitude scores between the control group and two interventional
groups before the intervention. However, after the intervention, there was a significant difference
in the knowledge and attitude of the students in the two interventional groups compared with
the control group (p<0.001). The knowledge score was significantly higher in the students' group
that was taught by the midwife (p<0.001). The attitude score was significantly higher in the students'
group to whom their mothers taught (p<0.001).

Conclusion:
Mothers would better improve the attitude of adolescent girls toward puberty health if
they were properly informed and knew how to transfer this information to their daughters. It seems
the involvement of mothers in the educating process by a specialist such as a midwife will have a
much better impact on the attitude and awareness of girls about puberty health.
Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation
Authors: Vu Tran Khac , Thanh Nguyen Thi , Minh Nguyen Van , Linh Nguyen Huong , Thao Nguyen Thi Phương , Nguyen Trương Thuc Bao , Hien Doan Thi , Chinh Luu Van , Duc Ta Hong , Anh Lai Duc , Hai Pham-The 
Published: April 2020

Background:
The target-based approach to drug discovery currently attracts a great deal
of interest from medicinal chemists in anticancer drug discovery and development. Histone deacetylase
(HDAC) inhibitors represent an extensive class of targeted anti-cancer agents. Among the
most explored structure moieties, hydroxybenzamides and hydroxypropenamides have been demonstrated
to have potential HDAC inhibitory effects. Several compounds of these structural classes
have been approved for clinical uses to treat different types of cancer, such as vorinostat and belinostat.

Aims:
This study aims at developing novel HDAC inhibitors bearing conjugated quinazolinone scaffolds with potential
cytotoxicity against different cancer cell lines.

Methods:
A series of novel N-hydroxyheptanamides incorporating conjugated 6-hydroxy-2 methylquinazolin-
4(3H)-ones (15a-l) was designed, synthesized and evaluated for HDAC inhibitory
potency as well as cytotoxicity against three human cancer cell lines, including HepG-2, MCF-7
and SKLu-1. Molecular simulations were finally performed to gain more insight into the structureactivity
relationships.

Results:
It was found that among novel conjugated quinazolinone-based hydroxamic acids synthesized,
compounds 15a, 15c and 15f were the most potent, both in terms of HDAC inhibition and
cytotoxicity. Especially, compound 15f displayed up to nearly 4-fold more potent than SAHA
(vorinostat) in terms of cytotoxicity against MCF-7 cell line with IC50 value of 1.86 μM, and
HDAC inhibition with IC50 value of 6.36 μM. Docking experiments on HDAC2 isozyme showed
that these compounds bound to HDAC2 with binding affinities ranging from -10.08 to -14.93
kcal/mol compared to SAHA (-15.84 kcal/mol). It was also found in this research that most of the
target compounds seemed to be more cytotoxic toward SKLu-1than MCF-7 and HepG-2.

Conclusion:
The resesrch results suggest that some hydroxamic acids could emerge for further
evaluation and the results are well served as basics for further design of more potent HDAC inhibitors
and antitumor agents.
Objective Characterization of Activity, Sleep, and Circadian Rhythm Patterns Using a Wrist-Worn Actigraphy Sensor: Insights Into Posttraumatic Stress Disorder
Authors: Tsanas Athanasios , Woodward Elizabeth , Ehlers Anke 
Published: April 2020

Background
Wearables have been gaining increasing momentum and have enormous potential to provide insights into daily life behaviors and longitudinal health monitoring. However, to date, there is still a lack of principled algorithmic framework to facilitate the analysis of actigraphy and objectively characterize day-by-day data patterns, particularly in cohorts with sleep problems.

Objective
This study aimed to propose a principled algorithmic framework for the assessment of activity, sleep, and circadian rhythm patterns in people with posttraumatic stress disorder (PTSD), a mental disorder with long-lasting distressing symptoms such as intrusive memories, avoidance behaviors, and sleep disturbance. In clinical practice, these symptoms are typically assessed using retrospective self-reports that are prone to recall bias. The aim of this study was to develop objective measures from patients’ everyday lives, which could potentially considerably enhance the understanding of symptoms, behaviors, and treatment effects.

Methods
Using a wrist-worn sensor, we recorded actigraphy, light, and temperature data over 7 consecutive days from three groups: 42 people diagnosed with PTSD, 43 traumatized controls, and 30 nontraumatized controls. The participants also completed a daily sleep diary over 7 days and the standardized Pittsburgh Sleep Quality Index questionnaire. We developed a novel approach to automatically determine sleep onset and offset, which can also capture awakenings that are crucial for assessing sleep quality. Moreover, we introduced a new intuitive methodology facilitating actigraphy exploration and characterize day-by-day data across 49 activity, sleep, and circadian rhythm patterns.

Results
We demonstrate that the new sleep detection algorithm closely matches the sleep onset and offset against the participants' sleep diaries consistently outperforming an existing open-access widely used approach. Participants with PTSD exhibited considerably more fragmented sleep patterns (as indicated by greater nocturnal activity, including awakenings) and greater intraday variability compared with traumatized and nontraumatized control groups, showing statistically significant (P<.05) and strong associations (|R|>0.3).

Conclusions
This study lays the foundation for objective assessment of activity, sleep, and circadian rhythm patterns using passively collected data from a wrist-worn sensor, facilitating large community studies to monitor longitudinally healthy and pathological cohorts under free-living conditions. These findings may be useful in clinical PTSD assessment and could inform therapy and monitoring of treatment effects.
Assessing the Credibility and Authenticity of Social Media Content for Applications in Health Communication: Scoping Review
Authors: Jenkins Eva L , Ilicic Jasmina , Barklamb Amy M , McCaffrey Tracy A 
Published: April 2020

BackgroundNutrition science is currently facing issues regarding the public’s perception of its credibility, with social media (SM) influencers increasingly becoming a key source for nutrition-related information with high engagement rates. Source credibility and, to an extent, authenticity have been widely studied in marketing and communications but have not yet been considered in the context of nutrition or health communication. Thus, an investigation into the factors that impact perceived source and message credibility and authenticity is of interest to inform health communication on SM.ObjectiveThis study aims to explore the factors that impact message and source credibility (which includes trustworthiness and expertise) or authenticity judgments on SM platforms to better inform nutrition science SM communication best practices.MethodsA total of 6 databases across a variety of disciplines were searched in March 2019. The inclusion criteria were experimental studies, studies focusing on microblogs, studies focusing on healthy adult populations, and studies focusing on either source credibility or authenticity. Exclusion criteria were studies involving participants aged under 18 years and clinical populations, gray literature, blogs, WeChat conversations, web-based reviews, non-English papers, and studies not involving participants’ perceptions.ResultsOverall, 22 eligible papers were included, giving a total of 25 research studies. Among these studies, Facebook and Twitter were the most common SM platforms investigated. The most effective communication style differed depending on the SM platform. Factors reported to impact credibility included language used online, expertise heuristics, and bandwagon heuristics. No papers were found that assessed authenticity.ConclusionsCredibility and authenticity are important concepts studied extensively in the marketing and communications disciplines; however, further research is required in a health context. Instagram is a less-researched platform in comparison with Facebook and Twitter.
Pemeliharaan Preventif Alat Elektromedik di Puskesmas Kecamatan Kebayoran Lama
Authors: Handayani Indah Nursyamsi 
Published: April 2020

Kegiatan pengabdian kepada masyarakat oleh Jurusan Teknik Elektromedik Poltekkes Kemenkes Jakarta II Tahun 2019 di wilayah Puskesmas Kecamatan Kebayoran Lama bekerjasama dengan Ikatan Elektromedis Indonesia dan PT. Medcalindo, dilaksanakan dalam rangka peningkatan pengetahuan tentang kegiatan pemeliharaan rutin yang merupakan bagian dari pemeliharaan preventif kepada operator atau pengguna alat. Metode yang digunakan dalam kegiatan ini dengan metode ceramah, diskusi dan tanya jawab. Kegiatan ini dihadiri oleh 43 peserta yang terdiri dari petugas pelayanan kesehatan di wilayah Puskesmas Kecamatan Kebayoran Lama sebanyak 28 orang, Dosen dan tenaga pengajar Teknik Elektromedik sebanyak 5 orang, mahasiswa jurusan Teknik Elektromedik sebanyak 2 orang, anggota DPC IKATEMI Jakarta Selatan sebanyak 5 orang dan Perwakilan PT. Medcalindo sebanyak 3 orang. Kegiatan PKM telah berjalan dengan baik dan memberikan manfaat berupa peningkatan pengetahuan dan pemahaman pemeliharaan alat elektromedik, manfaat lain yang diberikan yaitu kalibrasi dan pemeliharaan terhadap 25 peralatan elektromedik di wilayah Puskesmas Kecamatan Kebayoran Lama secara cuma-cuma.
O PROCESSO DE IMPLANTAÇÃO DA INTELIGÊNCIA COMPETITIVA EM UMA EMPRESA DE FACILITIES SERVICES
Authors: Domenes Priscila Michel , Urdan André Torres 
Published: April 2020

A inteligência competitiva é uma forma dinâmica em que as empresas buscam informações do mercado em que atuam e de seus concorrentes para um melhor posicionamento competitivo e estratégico. Esta atividade, que nem sempre é praticada formalmente dentro de uma empresa, pode ser implementada em diversas situações, como por conta de uma crise econômica financeira ou devido à drástica redução de seu faturamento, resultado da perda de clientes ou da não captação de novos. Baseado neste cenário, esta pesquisa tem o objetivo de compreender como foi o processo de implantação da inteligência competitiva em uma empresa de facilities services brasileira. Para isso, foi utilizado um estudo de caso único com três fontes de evidências, possibilitando a triangulação dos dados coletados. Como resultado, foi possível verificar as etapas deste processo, suas implicações na rotina administrativa e como novas informações e conhecimentos são utilizados nos direcionamentos da empresa.
Características da Produção Científica Brasileira sobre Cooperativas de Crédito no período entre 2006 e 2018
Authors: Santos Ramon Rodrigues dos , Santos Joséte Florêncio dos 
Published: April 2020

Este artigo buscou identificar os elementos que descrevem o perfil das publicações científicas sobre cooperativas de crédito nos principais periódicos nacionais e internacionais, realizando uma análise bibliométrica na Scopus no período de 2006 a 2018, contemplando os termos “cooperativas de crédito”, “credit cooperatives” e “credit unions”. Os principais resultados mostram que a produção científica brasileira indexada na Scopus ainda é incipiente, com 24 trabalhos publicados, cujo ano de 2017 concentrou aproximados 20,8% desta produção (5). Em maioria, os artigos são classificados na área “Negócios, Gestão e Contabilidade” e são predominantemente produzidos por autores da UFV e da UFMG. Em complemento, identificou-se que a rede de autores é isolada, não havendo cooperação entre os clusters.
Catatan Pembuka: Vox Populi Kembali Menyapa
Authors: Karim Syahrir 
Published: April 2020

Assalamualaikum Wr. Wb.Jurnal Vox Populi merupakan jurnal berkala yang diterbitkan oleh Program Studi Ilmu Politik, Fakultas Ushuluddin, Filsafat dan Ilmu Politik, Universitas Islam Negeri Alauddin Makassar. Sejatinya jurnal ini terbit dua kali dalam setahun, yakni: Juni dan Desember. Namun karena beberapa kendala sehingga Vox Populi hanya terbit satu kali sejak 2010 dalam versi cetak, setelah itu vakum. Saat ini, Vox Populi dirasa perlu menerbitkan kembali karya-karya hasil penelitian yang khusus menerbitkan karya ilmiah mahasiswa yang dianggap penting untuk diketahui publik secara luas. Olehnya itu, dengan ucapan rasa syukur kepada Allah Swt. Vox Populi dapat kembali menyapa pembaca secara online.
Polarisasi Dukungan Politik Muslimat dan Fatayat Nahdatul Ulama Pada Pilkada Serentak Tahun 2015 di Kabupaten Luwu Utara
Authors: Zainal Ahmad Aufa , Zainal Nur Aliyah , Syam Febrianto 
Published: April 2020

Studi ini mengkaji tentang polarisasi dukungan politik dan bentuk dukungan politik Muslimat dan Fatayat kepada Indah Putri Indriani-Thahar Rum pada Pilkada Serentak 2015 di Kabupaten Luwu Utara. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan menggunakan metode deskriptif, dengan informan yang meliputi elit Muslimat dan Fatayat Luwu Utara beserta anggota yang ditentukan dengan menggunakan teknik sampling porposive. Adapun teori yang digunakan adalah teori gender, teori partisipasi politik dan teori pilihan rasional (rational choise). Penelitian ini menunjukkan bahwa terdapat polarisasi dukungan politik yang diberikan kepada Indah Putri Indriani-Thahar Rum oleh Muslimat dan Fatayat. Secara umum dipermukaan dukungan politik yang diberikan kedua organisasi tersebut hanyalah semu sebab terdapat kepentingan politik yang berbeda antara keduanya. Muslimat secara tegas memberikan dukungan politik sedangkan Fatayat hanya nampak dipermukaan saja sebab ada kekhawatiran yang dirasakan yakni berkaitan dengan citra dan netralitas para pengurus dan anggota dari Fatayat itu sendiri.
Implementasi Media “Bosang” Untuk Mengasah Kecerdasan Logika Matematika Anak Usia Dini
Authors: Kristiana Dian 
Published: April 2020

AbstrakPenelitian ini bertujuan untuk mengetahui dampak implementasi media “bosang” dalam mengasah kecerdasan logika matematika. Penelitian ini merupakan pendekatan deskriptif kualitatif. Subyek dari penelitian ini adalah siswa kelompok B BA Aisyiyah Ronowijayan Ponorogo. Untuk mendapatkan data yang valid dalam peneliti ini menggunakan teknik pengumpulan data berupa observasi langsung, wawancara, dan dokumentasi. Teknik analisis data menggunakan model Miles & Huberman dimana terdapat tiga komponen utama yang harus benar-benar dipahami yaitu reduksi data (reduction data),penyajian data (display data),dan verifikasi/kesimpulan.Hasil penelitian implementasi media bosang untuk mengasah kecerdasan logika matematika di BA Ronowijayan Ponorogo dilakukan dalam tiga pertemuan dengan menggunakan 3 macam media bosang. Pada pertemuan pertama menggunakan media bosang transportasi. Pertemuan kedua menggunakan media bosang logika dan pertemuan terakhir menggunakan media lantai atau puzle karpet. Melalui implementasi media bosang ini, dari 15 indikator kecerdasan logika matematika yang ada sudah bisa diterapkan ada 13 indikator yaitu mengidentifikasi warna benda – benda di sekitarnya, memasangkan gambar benda dengan fungsi/kegunaannya, mengidentifikasi arah, memberi perhatian terhadap sesuatu disekitarnya, pemahaman konsep objek yang telah ditetapkan, pemahaman konsep persahabatan, menjelaskan waktu dalam rentang seminggu, merencanakan masa depan, membedakan bentuk, mengurutkan benda berdasarkan ukuran, warna, jenis permukaan dengan pola tertentu. Menghitung angka satuan, mengidentifikasi bentuk-bentuk geometri dalam satu benda serta menentukan ukuran benda yang ada disekitarnya.
Wireless Sensor Networks: Towards Resilience Against Weather-Based Disruptions
Authors: Skirelis Julius , Patlins Antons , Kunicina Nadezhda , Romanovs Andrejs , Zabasta Anatolijs 
Published: April 2020

Abstract
The article discusses vulnerability of wireless sensors networks to weather-based disruptions considering the opinions of different experts published in a range of scientific materials. The introduction provides a brief overview of wireless signals in real world conditions focusing on how weather affects signals (rain, fog and clouds, snow, hail, lightning, wind, bodies of water, trees and physical obstruction). Information about the effects of weather on wireless sensor networks using Free Space Optical / Radio Frequency (FSO/RF) communication is then provided. Finally, the impact of weather conditions on MANET routing protocols is considered theoretically, and experimental simulations are performed by comparing the sustainability of different protocols to different weather conditions. After analysis of experiment results, ideas on how to decrease vulnerability of wireless networks to weather-based disruptions are discussed.