bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR‐424: A novel potential therapeutic target and prognostic factor in malignancies
Authors: Dastmalchi Narges , Baradaran Behzad , Banan Khojasteh Seyed Mahdi , Hosseinpourfeizi Mohammadali , Safaralizadeh Reza 
Published: December 2020

AbstractmicroRNAs are endogenous, noncoding RNAs. Showing both tumor‐suppressive and oncogenic characteristics, miRNAs can regulate important processes in malignancies. This review aimed at highlighting the recent studies on the contribution of miR‐424 to the modulation of carcinogenesis and exploring its probable clinical effectiveness in the diagnosis and therapy of malignancies. The data were extracted from all papers published from 2013 until 2020. Mature miR‐424 leads to the degradation of its target transcripts or the suppression of translation via binding to the molecular targets. miR‐424 is involved in modulating p53, PI3K/Akt, Wnt, and other molecular pathways, thereby regulating cellular growth, apoptosis, differentiation, chemoresistance, and cancer immunity. miR‐424 was introduced as a tumor‐suppressive miR in numerous types of cancers while as an oncogene in several cancers. Regarding the cancer dependent role of miR‐424, it may be a prognostic and diagnostic biomarker and a potential candidate for the treatment of cancers.
Stromal‐derived miR‐486‐5p promotes metastasis of non‐small‐cell lung cancer cells by targeting the CADM1/tight junctions axis in vascular endothelial cells
Authors: Sun Bing , Han Yu , Shi Minhua 
Published: December 2020

AbstractSerum microRNA has been demonstrated as a noninvasive predictor for the progression of non‐small‐cell lung cancer (NSCLC). The role of microRNA‐486‐5p (miR‐486‐5p) in NSCLC seems to be paradoxical. On the one hand, elevated expression of miR‐486‐5p in serum is associated with unfavorable survival; on the other hand, miR‐486‐5p was notably reduced in NSCLC tissues and acted as a tumor‐suppressor to inhibit NSCLC metastasis. The expression of miR‐486‐5p was analyzed in serum and tissue samples and their relationship was explored. The miR‐486‐5p‐expressing cells were isolated by fluorescent‐activated cell sorting. The downstream target of miR‐486‐5p was identified by bioinformatics prediction and experimental confirmation. Functional studies of miR‐486‐5p on NSCLC metastasis were determined by endothelial permeability assay and trans‐endothelial invasion assay. We found that the expression of miR‐486‐5p was remarkably increased in serum, while dramatically downregulated in tumor tissues of NSCLC. However, the level of miR‐486‐5p in serum was positively correlated with that in tumor tissues. Next, we identified CD31+ vascular endothelial cells in the lung stroma as miR‐486‐5p‐expressing cells. According to bioinformatics prediction, quantitative real‐time reverse transcription PCR, luciferase reporter assay, and western blot, miR‐486‐5p directly targeted the cell adhesion molecule 1/tight junctions axis in vascular endothelial cells. In addition, endothelial permeability assay and trans‐endothelial invasion assay confirmed that miR‐486‐5p promoted NSCLC metastasis. Highly elevated expression of miR‐486‐5p in CD31+ vascular endothelial cells increased vascular permeability and promoted NSCLC metastasis. In conclusion, stromal‐derived miR‐486‐5p is responsible for the paradoxical effect of miR‐486‐5p in serum and tumor tissue.
Differential expression of circular RNAs in bone marrow‐derived exosomes from essential thrombocythemia patients
Authors: Wang Qiang , Yu Guopan , He Han , Zheng Zhongxin , Li Xuan , Lin Ren , Xu Dan 
Published: December 2020

AbstractCircular RNAs (circRNA) are closely associated with the pathogenesis of various hematological diseases. However, little is known about the potential functions of circRNAs in essential thrombocythemia (ET) development. The circRNA profile alterations in the bone marrow of ET patients were mainly investigated in this study. The sizes of exosomes derived from human bone marrow tissues were validated by the nanoparticle tracking analysis (NTA) method. CD63 and TSG101 expressions in exosomes were analyzed by western blot analysis. The profiles and differential expression of circRNAs in bone‐derived exosomes were characterized by high‐throughput sequencing. Herein, circular structures and expression of circRNAs were verified by Sanger sequencing and real‐time polymerase chain reaction, respectively. The circRNA‐miRNA‐mRNA networks were predicted using the Cytoscape software. And we detected the effect of circ_0014614 on the transformation of K562 cells into megakaryocytes. Exosomes derived from the bone marrow of ET patients and healthy volunteers showed a diameter between 70 and 140 nm and expressed high CD63 and TSG101. Meanwhile, the circRNA profiles were significantly altered in bone marrow–derived exosomes from ET patients, among which circDAP3, circASXL1, and circRUNX1 were significantly downregulated in ET patients, thus conferring a new insight into the role of circRNAs in the pathogenesis of ET. Besides this, circRNA‐encoding genes and miRNA‐mRNA networks targeted by this three circRNA were involved in various biological processes and signaling pathways. And circ_0014614 could inhibit K562 cells' differentiation into megakaryocytes. The predictions of the potential function of these three differentially expressed circRNAs along with their interaction with specific miRNAs could provide a basis for circRNA‐based ET diagnosis and treatment.
Outcomes of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary stenosis: A systematic review and meta‐analysis
Authors: Khan Abdul Ahad , Murtaza Ghulam , Khalid Muhammad Faisal , White Christopher J. , Mamas Mamas A. , Mukherjee Debabrata , Jneid Hani , Shanmugasundaram Madhan , Nagarajarao Harsha S. , Paul Timir K. 
Published: December 2020

AbstractIntroductionThe optimal approach to deal with severe coronary artery calcification (CAC) during percutaneous coronary intervention (PCI) remains ill‐defined.MethodsWe conducted an electronic database search of all published studies comparing Orbital versus Rotational Atherectomy in patients undergoing PCI.ResultsEight observational studies were included in the analysis. Overall, there were no significant differences in Major‐adverse‐cardiac‐events/MACE (OR: 0.81, CI: 0.63–1.05, p = .11), myocardial‐infarction/MI (OR: 0.75, CI: 0.56–1.00, p = .05), all‐cause mortality (OR: 0.82, CI: 0.25–2.64, p = .73) or Target‐vessel‐revascularization/TVR (OR: 0.72, CI: 0.38–1.36, p = .31). However, OA was associated with lower long‐term MACE (1‐year), (OR: 0.66, CI: 0.44–0.99, p = .04), long‐term TVR (OR: 0.40, CI: 0.18–0.89, p = .03), and short‐term MI (in‐hospital and 30‐day) (OR: 0.64, CI: 0.44–0.94, p = .02). OA was associated with more coronary artery dissections (OR: 2.61, CI: 1.38–4.92, p = .003) and device‐related coronary perforations (OR: 2.79, CI: 1.08–7.19, p = .03). There were no differences in cardiac tamponade (OR: 1.78, CI: 0.37–8.69, p = .47). OA was noted to have significantly lower fluoroscopy time (MD: −3.96 min, CI: −7.67, −0.25; p = .04) compared to RA. No significant difference was noted in terms of contrast volume between the two groups (OR: −4.35 ml, CI: −14.52, 23.22; p = .65).ConclusionAlthough there was no difference in overall MACE, MI, all‐cause mortality and TVR, OA was associated with lower long‐term MACE and short‐term MI. OA is associated with lower fluoroscopy time but higher rates of coronary artery dissection and coronary perforation.
Antimonium crudum in pediatric skin conditions: A classical homeopathic case series
Authors: Mahesh Seema , Kozymenko Tamara , Kolomiiets Nataliia , Vithoulkas George 
Published: December 2020

AbstractHomeopathic Antimonium crudum may be useful in many pediatric skin conditions if prescribed on symptom similarity. It may especially be helpful in reducing the use of antibiotics and steroids in this age‐group if proven to be effective through larger scientific studies.
Recent Advances of Oxygen Carriers for Chemical Looping Reforming of Methane
Authors: Tian Ming , Wang Chaojie , Han Yujia , Wang Xiaodong 
Published: December 2020

AbstractThis review discussed recent advances of oxygen carriers (OCs) for chemical looping reforming (CLR) of CH4 which aims to generate high‐quality syngas, an important chemical intermediate for the synthesis of chemicals and fuels. We firstly introduced CLR and that combined with CO2 and H2O splitting as well as clarified their advantages over conventional reforming processes. Then we reviewed the latest advances of metal‐based OCs, composite OCs including perovskites and hexaaluminates, and catalytic OCs, namely oxygen‐containing materials with catalytically metal sites, during the past five years. Specific discussion focused on the influence of composition, surface, and bulk structure of these OCs on conversion, selectivity, and lattice oxygen reactivity to summarize design and optimization strategies of the tailored OCs. Finally, a brief summary and an outlook on some of the scientific challenges and suggestions for future investigations on the development of outstanding OCs for CLR of CH4 are given.
Multiplatform collaborative detection resource scheduling method using K‐means clustering algorithm and Hungarian algorithm
Authors: Ni Tianquan , Jiang Yi 
Published: December 2020

SummaryAccording to the different situation electromagnetic environment, the multiplatform collaborative detection task is planned under the condition of meeting the requirements of multiplatform performance constraints and detection and positioning accuracy. In this article, the 6‐tuples of multiple‐platform detection attributes is defined, and then a multiple‐platform cooperative detection resource scheduling algorithm is established, and a cooperate adaptive evaluation method is proposed for coordination among all the platforms. Calculate the cooperate value among all the platforms. According to the cooperate value, the platform is clustered into a set of the same amount of objects, and then the expected core equipment of each set will be solved. The K‐means‐clustering technology and Hungarian technology are used to calculate and solve the matrix of the collaborative revenue value of the expected core equipment for the detection target. The feasibility, high adaptability, and the best distribution relationship of the collaborative revenue value are obtained. A kind of resource represented by the expected core equipment is allocated to the corresponding target for work, and the resource scheduling is completed. Multiplatform cooperative electronic detection tasks will be completed effectively in real time, and identify the targets quickly and accurately. Finally, we could complete the countertask.
Oriented Nickel Nanonetworks and Their Submicron Fibres as a Basis for a Transparent Electrically Conductive Coating
Authors: Nizameev Irek R. , Nizameeva Guliya R. , Faizullin Rashid R. , Kadirov Marsil K. 
Published: December 2020

AbstractThe paper demonstrates a technique for applying an oriented nickel network to a glass surface. The method is based on the chemical reduction of nickel salt. The shaping and orientation of the resulting system are carried out using a micellar template of a surfactant and a magnetic field. Submicron nickel fibres are used to impart unity to the plurality of individual‐oriented nickel nanonetworks. The result is a single conductive coating on the surface of the glass, which has a transparency in the optical range. Investigations of the structure, chemical composition, morphology and electrical conductivity of the coating were performed.
Singlet‐Triplet Excited‐State Inversion in Heptazine and Related Molecules: Assessment of TD‐DFT and ab initio Methods
Authors: Ricci G. , San‐Fabián E. , Olivier Y. , Sancho‐García J. C. 
Published: December 2020

AbstractWe have investigated the origin of the S1‐T1 energy levels inversion for heptazine, and other N‐doped π‐conjugated hydrocarbons, leading thus to an unusually negative singlet‐triplet energy gap (
). Since this inversion might rely on substantial doubly‐excited configurations to the S1 and/or T1 wavefunctions, we have systematically applied multi‐configurational SA‐CASSCF and SC‐NEVPT2 methods, SCS‐corrected CC2 and ADC(2) approaches, and linear‐response TD‐DFT, to analyze if the latter method could also face this challenging issue. We have also extended the study to B‐doped π‐conjugated systems, to see the effect of chemical composition on the results. For all the systems studied, an intricate interplay between the singlet‐triplet exchange interaction, the influence of doubly‐excited configurations, and the impact of dynamic correlation effects, serves to explain the
values found for most of the compounds, which is not predicted by TD‐DFT.
Taphonomic experiments imply a possible link between the evolution of multicellularity and the fossilization potential of soft‐bodied organisms
Authors: Naimark Elena , Kirpotin Dmitry , Boeva Natalia , Gmoshinskiy Vladimir , Kalinina Maria , Lyupina Yulia , Markov Alexander , Nikitin Michail , Shokurov Alexander , Volkov Dmitry 
Published: December 2020

AbstractThe reliability of evolutionary reconstructions based on the fossil record critically depends on our knowledge of the factors affecting the fossilization of soft‐bodied organisms. Despite considerable research effort, these factors are still poorly understood. In order to elucidate the main prerequisites for the preservation of soft‐bodied organisms, we conducted long‐term (1–5 years) taphonomic experiments with the model crustacean Artemia salina buried in five different sediments. The subsequent analysis of the carcasses and sediments revealed that, in our experimental settings, better preservation was associated with the fast deposition of aluminum and silicon on organic tissues. Other elements such as calcium, magnesium, and iron, which can also accumulate quickly on the carcasses, appear to be much less efficient in preventing decay. Next, we asked if the carcasses of uni‐ and multicellular organisms differ in their ability to accumulate aluminum ions on their surface. The experiments with the flagellate Euglena gracilis and the sponge Spongilla lacustris showed that aluminum ions are more readily deposited onto a multicellular body. This was further confirmed by the experiments with uni‐ and multicellular stages of the social ameba Dictyostelium discoideum. The results lead us to speculate that the evolution of cell adhesion molecules, which provide efficient cell–cell and cell–substrate binding, probably can explain the rich fossil record of soft‐bodied animals, the comparatively poor fossil record of nonskeletal unicellular eukaryotes, and the explosive emergence of the Cambrian diversity of soft‐bodied fossils.
Stereoisomeric Control in [RuCl2(PTA)2(2L)] Complexes (2L=2py or bpy): From Theoretical Calculations to a 2+2 Metallacycle of Pyridylporphyrins
Authors: Vidal Alessio , Battistin Federica , Milani Barbara , Balducci Gabriele , Alessio Enzo 
Published: December 2020

AbstractTreatment of the Ru(II) precursor cis,cis,trans‐[RuCl2(dmso‐S)2(PTA)2] (1, PTA=1,3,5‐triaza‐7‐phosphaadamantane) with 2,2′‐bipyridine (bpy) in refluxing ethanol selectively affords cis,cis‐[Ru(bpy)Cl2(PTA)2] (2), whereas with pyridine (py), under the same conditions, it gives trans,cis,cis‐[RuCl2(PTA)2(py)2] (6). The slightly less stable stereoisomer of 2, cis,trans‐[Ru(bpy)Cl2(PTA)2] (3), is obtained selectively through a different synthetic route. Isomers 2 and 3 are thermally stable, but cleanly equilibrate upon irradiation of an aqueous solution of either one with blue light. Intrigued by the stereoisomeric outcome in the preparations of this homogeneous set of complexes, we also investigated 2, 3, and 6 (and the mono‐pyridine complex trans,mer‐[RuCl2(py)(PTA)3] (7)) through a topological analysis of the electron density map using the quantum theory of atoms in molecules (QTAIM). The wealth of acquired experimental and calculated data allow us to discuss the stereochemical preferences of the [RuCl2(PTA)2(2 L)] complexes (2 L=bpy or 2py) in terms of electronic and steric contributions. The results of this speculative study on model complexes are transferable to similar systems. As an example, our findings from the reactivity of 1 towards pyridine allowed us to prepare the 2+2 pyridylporphyrin metallacycle trans,cis,cis‐[RuCl2(PTA)2(4′‐cisDPyP)]2 (10, 4′‐cisDPyP=5,10‐(4′‐pyridyl)‐15,20‐(phenyl)‐porphyrin), whose X‐ray molecular structure is also reported.
Design of heat storage networks for repeatable batch processes
Authors: Anastasovski Aleksandar 
Published: December 2020

AbstractHeat integration of repeatable batches with heat storage is a complex problem. This article suggests a new approach in the determination of possible heat storage for repeatable batch processes. This approach is based on the TRANSSHIPMENT method. The surplus heat and cold from streams and stream segments are added to the already designed heat exchanger networks for each time slice. These streams or stream segments from other time slices are supposed to match with streams or stream segments in a particular time slice. The heat content together with the changed supply and target temperatures of streams, and the minimal temperature difference for heat exchange are the main parameters used in the suggested method. The proposed technique creates a heat exchanger network between streams and potential heat storage at different times. The solution is a secondary network of heat storage units. The benefit in design of the solution is heat recovery for 11.51 kW per cycle of the analyzed case study. The annual heat recovery by cooling and heating separately is 4488.1 kW. As a result of suggested solution, the waste heat is minimized for approximately 13.5%.
Effects of aqueous ozone treatment on microbial growth, quality, and pesticide residue of fresh‐cut cabbage
Authors: Liu Chenghui , Chen Chen , Jiang Aili , Zhang Yanhui , Zhao Qiqi , Hu Wenzhong 
Published: December 2020

AbstractThe influence of aqueous ozone (1.4 mg/L) treatment for 1, 5, and 10 min on the microbial growth and quality attributes of fresh‐cut cabbage during storage at 4°C for 12 days was evaluated. The pesticide residue removal effect of aqueous ozone treatment for 5 min was also determined. The results show that the growth rates of aerobic bacteria, coliforms, and yeasts were significantly inhibited (p < .05) by aqueous ozone treatment during storage; treatment for 10 min showed the greatest inactivation of bacteria, coliforms, and molds. Aqueous ozone stimulated initial respiratory metabolism compared with that of the control. Aqueous ozone treatments reduced ethylene production and improved the overall quality of fresh‐cut cabbage. In addition, the effect of aqueous ozone treatment for 5 min on the removal of trichlorfon, chlorpyrifos, methomyl, dichlorvos, and omethoate from fresh‐cut cabbage was greater (p < .05) than that of the control. These results indicate that aqueous ozone treatment for 5 min could be an economic and effective method to remove pesticide residues and enhance the storability of fresh‐cut cabbage.
Geophysical assessment of Verteba Cave Eneolithic site, Ukraine
Authors: Bondar Kseniia M. , Sokhatskyi Mykhailo P. , Chernov Anatolii , Popko Yaroslav , Petrokushyn Oleh , Baryshnikova Mariia , Khomenko Ruslan , Boyko Myroslav 
Published: December 2020

AbstractThe set of geophysical methods employed above ground and inside Verteba Cave Eneolithic Trypillian Culture Site (Ukraine) includes magnetic survey, electrical resistivity tomography (ERT), and ground‐penetrating radar (GPR). The above‐ground geophysical study was aimed at the recognition of lateral and vertical distribution of sulfate karst landforms and archaeological targets. In‐cave measurements were made to prospect archaeological remains in loose infill and unknown voids. The round and oval‐shaped magnetic anomalies with dimensions of 10–25 m and maximum intensity of 15–20 nT are caused by old refilled collapse dolines that were discovered over the cave. The magnetic survey proved the absence of Trypillian culture houses on the surface and the presence of buried archaeological objects in the cave. 2D ERT imaging revealed the vertical structure of karstic collapse dolines, the thickness of the sedimentary layer over gypsum, as well as loamy cave infill. ERT was capable of detecting the void in gypsum by resistivity enhancement up to several thousand ohm‐meters. The underground GPR survey of cave walls provided information about possible vertical air−gypsum and loam−gypsum interfaces within the gypsum layer. The prospective areas for future archaeological excavations and the possible location of undiscovered cavities were outlined on the basis of geophysical results.
Distribution pattern of the brackish Apocorophium lacustre (Vanhoffen, 1911) (Amphipoda: Corophiidae) and the structure of the amphipod assemblages in the upper Oder River catchment
Authors: Krodkiewska Mariola , Rewicz Tomasz , Cebulska Klaudia , Koczorowska Adrianna , Konopacka Alicja 
Published: December 2020

Abstract
Apocorophium lacustre (Vanhoffen, 1911), which is a native brackish amphipod species of the North Atlantic and Baltic coasts, was recorded in the upper Oder River for the first time in 2017. Before that, only alien amphipod species had been found in this area. The aims of the study were to describe the distribution pattern of A. lacustre in the upper Oder River catchment, to investigate the composition and structure of the amphipod assemblages against the background of the habitat conditions and to provide a genetic identification of the species using DNA barcodes. In total, 16 sites were studied. A. lacustre was recorded in 14 of them. It was not found at one site in the Oder River and at one location in the lower Klodnica River. A. lacustre outnumbered the other amphipods in the Oder, in the mouth section of the Klodnica and at one site in the Gliwice Canal. The alien species Gammarus tigrinus (Sexton, 1939) was dominant in the amphipod communities at the southernmost site in the Oder River, in the Klodnica Canal, and at most sites along the Gliwice Canal. In the Klodnica River, another alien species, Dikerogammarus villosus (Sovinsky, 1894), was dominant in the amphipod fauna at two sites. Though the density of A. lacustre was high in the Oder River, it was much lower in both the canals and the Klodnica River. In our study, the depth and river velocity both contributed to the distribution of this species.
Using Culturally Relevant Pedagogy to Influence Literacy Achievement for Middle School Black Male Students
Authors: Walker Shontoria , Hutchison Laveria 
Published: December 2020

AbstractThis paper describes how the literacy achievement of low socioeconomic status 17 Black male middle school students in one classroom was influenced by culturally responsive teaching. The study employed a concurrent transformative mixed‐methods approach. Quantitative data consisted of pretest and posttest reading scores from the computer adaptive interim assessment, Measurement of Academic Progress during the 2017–2018 academic school year. Qualitative data included the teacher’s journal of reflective field notes. The findings suggested that pedagogy that mirrors students’ cultural values, beliefs, and lifestyles empowered students in ways that yielded improved literacy achievement for this group. This study added further support for the use of such pedagogy with Black male students as well as other potentially vulnerable populations.