bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of segment 4 portal vein embolization added to right portal vein for right hepatic trisectionectomy: A retrospective propensity score‐matched study
Authors: Ito Jun , Komada Tomohiro , Suzuki Kojiro , Matsushima Masaya , Nakatochi Masahiro , Kobayashi Yumiko , Ebata Tomoki , Naganawa Shinji , Nagino Masato 
Published: February 2020

AbstractBackgroundAdding segment 4 (S4) portal vein embolization (PVE) to right PVE before right hepatic trisectionectomy is controversial. We retrospectively examined the effect of S4 PVE on segments 2 and 3 (S2 + 3) hypertrophy.MethodsWe reviewed patients with biliary carcinoma who underwent right PVE with (R3PVE) or without (R2PVE) S4 PVE using gelatin sponge particles and coils (2010‐2019). Propensity score matching balanced the cohort for baseline characteristics, including total liver volume and S2 + 3 volume before PVE. We compared the groups regarding the S2 + 3 volume changes after PVE.ResultsOf 178 enrolled patients, 38 underwent R3PVE for right hepatic trisectionectomy and 140 underwent R2PVE for right hepatectomy. Twenty‐eight patients from each group were respectively matched. The median absolute volume increase in (146 cm3 vs 70 cm3), hypertrophy rate of (52.4% vs 32.3%), and kinetic growth rate of (3.1%/wk vs 2.0%/wk) S2 + 3 were significantly higher in the R3PVE group than in the R2PVE group. In the pre‐matched cohort, the rate of posthepatectomy liver failure and postoperative hospital stay did not significantly differ between the patients who underwent right hepatic trisectionectomy and right hepatectomy.ConclusionR3PVE increased the S2 + 3 volume more effectively than R2PVE in patients with biliary carcinoma.
Separation of acteoside and linarin from Buddlejae Flos by high‐speed countercurrent chromatography and their anti‐inflammatory activities
Authors: Xie Guoyong , Yang Jie , Wei Xiaonan , Xu Qiuhong , Qin Minjian 
Published: February 2020

AbstractBuddleja officinalis Maxim., a deciduous, flowering shrub, is used as a traditional Chinese medicine; the bioactivity of B. officinalis is primarily due to flavonoids and phenylethanoid glycosides. In the study, acteoside and linarin were successfully isolated from B. officinalis by high‐speed countercurrent chromatography with a two‐phase solvent system composed of ethyl acetate: n‐butanol: water (5:0.8:5, v/v/v). The purities of acteoside and linarin were determined to be 97.3 and 98.2%, respectively, using one‐step high‐speed countercurrent chromatography separation. The chemical structures of the two compounds were identified by electrospray ionization‐mass spectrometry and nuclear magnetic resonance. After separation, the anti‐inflammatory effects of the two compounds were evaluated using lipopolysaccharide‐induced human umbilical vein endothelial cells. Acteoside and linarin inhibited the expression of nitric oxide, tumor necrosis factor α and interleukin 1β, which demonstrated that acteoside and linarin possessed anti‐inflammatory activity.
Question Mark Sign and Transvaginal Ultrasound Uterine Tenderness for the Diagnosis of Adenomyosis
Authors: Zannoni Letizia , Ambrosio Marco , Raimondo Diego , Arena Alessandro , Del Forno Simona , Borghese Giulia , Paradisi Roberto , Seracchioli Renato 
Published: February 2020

ObjectivesTo evaluate the diagnostic accuracy of the classic ultrasound (US) signs of adenomyosis, the question mark sign and transvaginal ultrasound (TVUS) uterine tenderness, in the diagnosis of adenomyosis.MethodsThis was a prospective study including 78 patients waiting for hysterectomy for uterine benign diseases and undergoing preoperative US examinations to evaluate all criteria for US diagnosis of adenomyosis as reported by the consensus statement of the Morphological Uterus Sonographic Assessment group. A US diagnosis of adenomyosis was made in the presence of 2 or more Morphological Uterus Sonographic Assessment features. Moreover, the question mark sign and TVUS uterine tenderness were evaluated. Ultrasound features were compared with the histologic examination, which was considered the reference standard for the diagnosis of adenomyosis. The Cohen κ coefficient was used to measure the accordance between US and histologic results. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of each US feature were calculated.ResultsThe prevalence of adenomyosis in the sample was 33.3%. The sensitivity, specificity, PPV, NPV, and accuracy of TVUS in the diagnosis of adenomyosis were 77%, 96%, 91%, 89%, and 90%, respectively. Myometrial heterogeneity was the most frequently encountered feature (100%) but showed low specificity (7%). The question mark sign and TVUS uterine tenderness showed sensitivity, specificity, PPV, NPV, and accuracy of 41%, 96%, 83%, 77%, and 69% and 69%, 65%, 66%, 81%, and 67%.ConclusionsThe question mark sign and TVUS uterine tenderness are useful tools for the diagnosis of adenomyosis.
Histopathological characteristics of surgical tissue from primary vs recurrent chronic rhinosinusitis with nasal polyposis patients
Authors: Donnell Nathaniel J. , Marino Michael J. , Zarka Matthew A. , Lal Devyani 
Published: February 2020

AbstractObjectiveThe histopathological characteristics of primary vs recurrent nasal polyps in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have not been studied comprehensively. Identification of these features may be helpful for prognostication, postoperative management, and consideration of novel eosinophil‐targeting biologic therapy. This study investigates the histopathological differences in primary vs recurrent CRSwNP tissue.MethodsPatients undergoing endoscopic sinus surgery for CRSwNP were included if all 13 histopathological and mucin characteristics on a standardized report were available. Histopathology parameters were compared in surgical tissue and mucin from primary vs recurrent CRSwNP.ResultsComplete structured histopathology reports were available for 96 patients (39 primary polyps and 57 recurrent polyps). Compared to primary polyp tissue, recurrent CRSwNP mucin was significantly more likely to feature eosinophil aggregates (57.9% vs 35.9%; P = .047). Tissue eosinophilia (using a threshold >10 per high power field [HPF]) was not significantly different in primary and recurrent CRSwNP tissue. Other histopathologic parameters and clinical characteristics were similar.ConclusionEosinophil aggregates on histopathology are significantly more likely to be present in recurrent CRSwNP. In the limited series, tissue eosinophilia (>10 per HPF) was not significantly different in primary and recurrent CRSwNP. Therefore, in addition to the study of tissue eosinophilia levels, Rhinologic surgeons should also direct attention to CRSwNP mucin. Mucin eosinophilic aggregates are an independent marker of severe inflammation that is associated more likely with recurrent vs primary polyposis. Further study of this marker may help determine its role of choice of postoperative medical therapies, including anti‐eosinophilic biologics.Level of Evidence4
High‐Salt Diet‐Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet
Authors: Li Ya , Li Wen , Wang Xiao , Ding Chao , Liu Junze , Li Yan , Li Wenjuan , Sun Yundong 
Published: February 2020

ScopeA high‐salt diet is a cause of gastritis, but the associated mechanism remains unclear. Recent studies have shown that gastric flora is associated with a variety of stomach diseases, but it is not known whether gastric flora is involved in gastritis induced by a high‐salt diet.Methods and resultsGastritis is successfully induced in C57BL/6 mice fed a high‐salt diet (salt: 5% NaCl) for four weeks. Through 16S rRNA gene sequencing, the composition of the stomach microbiota of mice fed normal and high‐salt diets are compared, the results of which show that the high‐salt diet induces significant changes in the gastric flora. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) is used to predict the function of the microbiota in the stomach of mice, and the results indicate that a high‐salt diet leads to a decrease in the ability of the gastric microbiota to metabolize polysaccharides and vitamins. A buckwheat diet is used to treat gastritis. The results show gastritis induced by the high‐salt diet is significantly alleviated, and the dysbiosis in the stomach also improved.ConclusionBuckwheat diet may be one of the ways to prevent and treat gastritis caused by a high‐salt diet.
Recurrent attention network for false positive reduction in the detection of pulmonary nodules in thoracic CT scans
Authors: Farhangi M. Mehdi , Petrick Nicholas , Sahiner Berkman , Frigui Hichem , Amini Amir A. , Pezeshk Aria 
Published: February 2020

PurposeMultiview two‐dimensional (2D) convolutional neural networks (CNNs) and three‐dimensional (3D) CNNs have been successfully used for analyzing volumetric data in many state‐of‐the‐art medical imaging applications. We propose an alternative modular framework that analyzes volumetric data with an approach that is analogous to radiologists’ interpretation, and apply the framework to reduce false positives that are generated in computer‐aided detection (CADe) systems for pulmonary nodules in thoracic computed tomography (CT) scans.MethodsIn our approach, a deep network consisting of 2D CNNs first processes slices individually. The features extracted in this stage are then passed to a recurrent neural network (RNN), thereby modeling consecutive slices as a sequence of temporal data and capturing the contextual information across all three dimensions in the volume of interest. Outputs of the RNN layer are weighed before the final fully connected layer, enabling the network to scale the importance of different slices within a volume of interest in an end‐to‐end training framework.ResultsWe validated the proposed architecture on the false positive reduction track of the lung nodule analysis (LUNA) challenge for pulmonary nodule detection in chest CT scans, and obtained competitive results compared to 3D CNNs. Our results show that the proposed approach can encode the 3D information in volumetric data effectively by achieving a sensitivity >0.8 with just 1/8 false positives per scan.ConclusionsOur experimental results demonstrate the effectiveness of temporal analysis of volumetric images for the application of false positive reduction in chest CT scans and show that state‐of‐the‐art 2D architectures from the literature can be directly applied to analyzing volumetric medical data. As newer and better 2D architectures are being developed at a much faster rate compared to 3D architectures, our approach makes it easy to obtain state‐of‐the‐art performance on volumetric data using new 2D architectures.
Soziodemografische und erwerbsbezogene Merkmale in der NAKO Gesundheitsstudie
Authors: Dragano Nico , Reuter Marvin , Greiser Karin Halina , Becher Heiko , Zeeb Hajo , Mikolajczyk Rafael , Kluttig Alexander , Leitzmann Michael , Fischer Beate , Jöckel Karl-Heinz , Emmel Carina , Krause Gérard , Castell Stefanie , Damms-Machado Antje , Obi Nadia , Schikowski Tamara , Kuss Oliver , Hoffmann Wolfgang , Schipf Sabine , Pischon Tobias , Jaeschke Lina , Krist Lilian , Keil Thomas , Lieb Wolfgang , Holleczek Bernd , Brenner Hermann , Wirkner Kerstin , Loeffler Markus , Michels Karin B. , Franzke Claus-Werner , Peters Annette , Linseisen Jakob , Berger Klaus , Legath Nicole , Ahrens Wolfgang , Lampert Thomas , Schmidt Börge 
Published: February 2020

ZusammenfassungHintergrundIn epidemiologischen Studien ist die standardisierte Erfassung soziodemografischer Merkmale von hoher Bedeutung, da Variablen wie Geschlecht, Alter, Bildung oder Erwerbsstatus wichtige Einflussfaktoren auf Gesundheitschancen und Krankheitsrisiken darstellen. In der NAKO Gesundheitsstudie werden zentrale Faktoren aus diesem Themenbereich berücksichtigt.Ziel der ArbeitDer Beitrag gibt einen Überblick über den wissenschaftlichen Hintergrund und die konkrete Erhebung soziodemografischer Angaben in der NAKO. Zudem werden die Verteilung einzelner Merkmale sowie Zusammenhänge mit gesundheitsassoziierten Maßen exemplarisch vorgestellt.Material und MethodenAnhand der Daten zur Halbzeit der Basiserhebung (n = 101.724) wurde die Verteilung soziodemografischer Merkmale dargestellt und Zusammenhänge mit beispielhaft ausgewählten Gesundheitsindikatoren (Body-Mass-Index, selbst berichtete Gesundheit) analysiert, um die Validität der Messung soziodemografischer Angaben zu beurteilen.ErgebnisseDas mittlere Alter der Teilnehmenden lag bei 52,0 Jahren (SD = 12,4). 53,6 % der Teilnehmenden waren Frauen, 54,3 % hatten einen hohen Bildungsabschluss, 60,1 % waren verheiratet zusammenlebend, 72,0 % erwerbstätig und 3,4 % erwerbslos. Bekannte Zusammenhänge zwischen Soziodemografie und Gesundheit konnten reproduziert werden. So waren niedrige Bildung, hohes Alter und Erwerbslosigkeit mit einer erhöhten Häufigkeit von Adipositas und schlechter selbst berichteter Gesundheit assoziiert.DiskussionDie NAKO Gesundheitsstudie erhebt viele soziodemografische Merkmale. In Kombination mit der Fülle an Gesundheitsdaten und dem Längsschnittdesign ergeben sich so neue Möglichkeiten für die gesundheitswissenschaftliche und sozialepidemiologische Forschung in Deutschland.
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study
Authors: Suero Molina Eric , Stögbauer Louise , Jeibmann Astrid , Warneke Nils , Stummer Walter 
Published: February 2020

Abstract
Background
The BLUE 400 filter system (Carl Zeiss Meditec, Oberkochen, Germany) has provided visualization of 5-ALA-induced fluorescence-guided surgery for more than 20 years. Nevertheless, constraints, e.g., limited background discrimination during hemostasis, obstruct fluency of surgery. A novel filter with improved background visualization was developed, requiring validation regarding fluorescence discrimination. The aim of this article is to determine diagnostic accuracy and perception of protoporphyrin IX (PpIX) discrimination of a novel filter system with higher background illumination (BLUE 400 AR) compared with the gold standard, BLUE 400.

Methods
A surgical microscope equipped with both BLUE 400 and BLUE 400 AR was used. Comparisons were performed on a biological basis and on the visual perception of margins. High-resolution images were compared during and after surgery by senior neurosurgeons. In a predefined biopsy algorithm, four biopsies per patient at tumor margins of PpIX fluorescence and adjacent brain were acquired using BLUE 400 AR only from regions intended for resection and assessed for cell count and density.

Results
Thirty-two patients with malignant gliomas were included in this study. BLUE 400 AR markedly enhanced the brightness of the surgical field, allowing superior discrimination of brain anatomy. A total of 128 biopsies from fluorescence margins were collected. Positive predictive value (PPV) was 98.44% (95% CI, 90.06–99.77%) for malignant glioma. Residual median cell density in non-fluorescent tissue was 13% (IQR 13 to 31). Perception of the location of fluorescent margins on HD images was equivalent for both filter combinations.

Conclusions
BLUE 400 AR demonstrated superior background compared with conventional BLUE 400 in malignant glioma surgery but comparable fluorescence margins and PPV. Therefore, BLUE 400 AR can be considered safe and effective in supporting malignant glioma surgery.
Impact of inertia and channel angles on flow distribution in microfluidic junctions
Authors: Blonski S. , Zaremba D. , Jachimek M. , Jakiela S. , Wacławczyk T. , Korczyk P. M. 
Published: February 2020

AbstractIn the present paper, we provide evidence of the vital impact of inertia on the flow in microfluidic networks, which is disclosed by the appearance of nonlinear velocity–pressure coupling. The experiments and numerical analysis of microfluidic junctions within the range of moderate Reynolds number (1 < Re < 250) revealed that inertial effects are of high relevance when Re > 10. Thus, our results estimate the applicability limit of the linear relationship between the flow rate and pressure drop in channels, commonly described by the so-called hydraulic resistance. Herein, we show that neglecting the nonlinear in their nature inertial effects can make such linear resistance-based approximation mistaken for the network operating beyond Re < 10. In the course of our research, we investigated the distribution of flows in connections of three channels in two flow modes. In the splitting mode, the flow from a common channel divides between two outputs, while in the merging mode, streams from two channels join together in a common duct. We tested a wide range of junction geometries characterized by parameters such as: (1) the angle between bifurcating channels (45°, 90°, 135° and 180°); (2) angle of the common channel relative to bifurcating channels (varied within the available range); (3) ratio of lengths of bifurcating channels (up to 8). The research revealed that the inertial effects strongly depend on angles between the channels. Additionally, we observed substantial differences between the distributions of flows in the splitting and merging modes in the same geometries, which reflects the non-reversibility of the motion of an inertial fluid. The promising aspect of our research is that for some combinations of both lengths and angles of the channels, the inertial contributions balance each other in such a way that the equations recover their linear character. In such an optimal configuration, the dependence on Reynolds number can be effectively mitigated.
The Support Interval
Authors: Wagenmakers Eric-Jan , Gronau Quentin F. , Dablander Fabian , Etz Alexander 
Published: February 2020

AbstractA frequentist confidence interval can be constructed by inverting a hypothesis test, such that the interval contains only parameter values that would not have been rejected by the test. We show how a similar definition can be employed to construct a Bayesian support interval. Consistent with Carnap’s theory of corroboration, the support interval contains only parameter values that receive at least some minimum amount of support from the data. The support interval is not subject to Lindley’s paradox and provides an evidence-based perspective on inference that differs from the belief-based perspective that forms the basis of the standard Bayesian credible interval.
Associations between Ethnic Minority Status and Popularity in Adolescence: the role of Ethnic Classroom Composition and Aggression
Authors: Stevens Gonneke W. J. M. , Veldkamp Carolien , Harakeh Zeena , Laninga-Wijnen Lydia 
Published: February 2020

AbstractAlthough there are theoretical reasons to expect an association between ethnic minority status and popularity, research on this topic is scarce. Therefore, this association was investigated including the moderating role of the ethnic classroom composition and the mediating role of aggression. Data from the longitudinal Dutch SNARE (Social Network Analysis of Risk behavior in Early adolescence) project were used among first-year students (comparable to 5th grade) (N = 1134, Nclassrooms = 51, M = 12.5 years, 137 non-Western ethnic minority students). Popularity and aggression were assessed with peer nominations. Multi-level Structural Equation Models showed that ethnic minority status was indirectly associated with higher popularity, through higher aggression. Moreover, with increasing numbers of ethnic minority students in the classroom, popularity levels of both ethnic majority and ethnic minority students decreased. Only when differences in aggression between ethnic minority and majority students were included in the analyses, while the ethnic classroom composition was not included, lower popularity levels were found for ethnic minority than ethnic majority students. Scientific and practical implications of this study were addressed in the discussion.
University vs. Research Institute? The Dual Pillars of German Science Production, 1950–2010
Authors: Dusdal Jennifer , Powell Justin J. W. , Baker David P. , Fu Yuan Chih , Shamekhi Yahya , Stock Manfred 
Published: February 2020

AbstractThe world’s third largest producer of scientific research, Germany, is the origin of the research university and the independent, extra-university research institute. Its dual-pillar research policy differentiates these organizational forms functionally: universities specialize in advanced research-based teaching; institutes specialize intensely on research. Over the past decades this policy affected each sector differently: while universities suffered a lingering “legitimation crisis,” institutes enjoyed deepening “favored sponsorship”—financial and reputational advantages. Universities led the nation’s reestablishment of scientific prominence among the highly competitive European and global science systems after WWII. But sectoral analysis of contributions to science, technology, engineering, mathematics, and medical and health journal publications (1950–2010) finds that Germany’s small to medium-sized independent research institutes have made significant, growing contributions, particularly in publishing in higher impact journals proportionally more than their size. Simultaneously—despite dual-pillar policy implications—the university sector continues to be absolutely and relatively successful; not eclipsed by the institutes. Universities have consistently produced two-thirds of the nation’s publications in the highest quality journals since at least 1980 and have increased publications at a logarithmic rate; higher than the international mean. Indeed, they led Germany into the global mega-science style of production. Contrary to assumed benefits of functional differentiation, our results indicate that relative to their size, each sector has produced approximately similar publication records. While institutes have succeeded, the larger university sector, despite much less funding growth, has remained fundamental to German science production. Considering these findings, we discuss the future utility of the dual-pillar policy.
Transplanting institutional innovation: comparing the success of NGOs and missionary Protestantism in sub-Saharan Africa
Authors: Burchardt Marian , Swidler Ann 
Published: February 2020

AbstractViewing missionary Protestantism and non-governmental organizations (NGOs) as carriers of transnational institutional innovation, this article compares their successes and failures at creating self-sustaining institutions in distant societies. Missionary Protestantism and NGOs are similar in that they attempt to establish formal organizations outside kinship, lineage, and ethnic forms of solidarity. Focusing on institutions as ways to create collective capacities that organize social life, we trace the route whereby Protestant missionaries established congregational religion in Africa and identify social practices that made this enterprise successful but are comparatively absent in current NGO attempts to transform organizational life. Largely ignored by sociologists interested in institutional transformation, the history of congregational religion offers valuable sociological lessons about the conditions for radical institutional innovation. Its success was rooted first, in colonial missionaries’ ability to enforce new ways of life on small exemplary communities; second, in local adaptations (African prophetic movements, Pentecostalism) that deepened and widened the social reach of congregational principles; and third in the incentives Protestantism created for propagating the congregational form.