bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of resveratrol in enrichment of neural progenitor-like cells induction of human stem cells from apical papilla
Authors: Songsaad Anupong , Gonmanee Thanasup , Ruangsawasdi Nisarat , Phruksaniyom Chareerut , Thonabulsombat Charoensri 
Published: December 2020

Abstract
Introduction: Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach of neurodegenerative disease. Human stem cells from apical papilla (hSCAPs) are derived from migratory neural crest stem cells, and exhibit a potential of neuronal differentiation. However, their neuronal differentiation is low and unpredictable. Resveratrol has been described as a sirtuin 1 (SIRT1) activator which plays an important role in enhancing neuronal differentiation. In this study, we investigate the potential of resveratrol as an enhancer on neuronal differentiation through NPCs induction of hSCAPs.Methods: Stem cells were isolated from human apical papilla, and characterized as MSCs. The cellular toxicity of resveratrol treatment to the characterized hSCAPs was investigated by MTT assay. The non-cellular toxicity concentrations of resveratrol were assessed with various pre-treatment times to select the optimal condition that highly expressed the neural progenitor gene, NES. Consequently, the optimal condition of resveratrol pre-treatment was synergistically performed with a neuronal induction medium to trigger neuronal differentiation. The differentiated cells were visualized, the genes profiling was quantified, and the percentage of neuronal differentiation was calculated. Moreover, the intracellular calcium oscillation was demonstrated. Results: The cellular toxicity of resveratrol was not observed for up to 50 µM for 12 hours. Interestingly, hSCAPs pre-treated with 10 µM resveratrol for 12 hours (RSV-hSCAPs) significantly expressed NES, which is determined as the optimal condition. Under neuronal induction, both of hSCAPs and RSV-hSCAPs were differentiated (d-hSCAPs, and RSV-d-hSCAPs) as they exhibited neuronal-like appearances with Nissl substance staining. The highest expression of NES, and SOX1 was observed in RSV-d-hSCAPs. Additionally, the percentage of neuronal differentiation of RSV-d-hSCAPs was significantly higher than d-hSCAPs for 4 times. Importantly, the neuronal-like cells exhibited slightly increasing pattern of calcium intensity.Conclusion: This study demonstrated that pre-treatment of resveratrol strongly induces neural progenitor marker gene expression which synergistically enhances neural progenitor-like cells’ induction with neuronal induction medium.
Unplanned hospital readmission after surgical treatment for thoracic spinal stenosis: incidence and causative factors
Authors: Wang Hui , Wang Longjie , Sun Zhuoran , Jiang Shuai , Li Weishi 
Published: December 2020

Abstract
Background To assess the incidence and causative factors of unplanned hospital readmission within 90 days after surgical treatment of thoracic spinal stenosis (TSS).Methods Hospital administrative database was queried to identify patients who underwent surgical treatment of TSS from July 2010 through December 2017. All unplanned readmissions within 90 days of discharge were reviewed for causes and the rate of unplanned readmissions was calculated. Patients of unplanned readmission were matched 1:3 to a control cohort without readmission.Results Twenty-one patients (incidence of 1.7% in 1239 patients) presented unplanned hospital readmission within a 90-day period and enrolled as the study group, 63 non-readmission patients (a proportion of 1: 3) were randomly selected as the control group. Causes of readmission include pseudomeningocele (8 patients; 38%), CSF leakage combined with poor incision healing (6 patients; 29%), wound dehiscence (2 patient; 9%), surgical site infection (2 patients; 9%), spinal epidural hematoma (1 patient; 5%), inadequate original surgical decompression (2 patients; 9%). Mean duration from re-admission to the first surgery was 39.6±28.2 days, most of the patients readmitted at the first 40 days (66.7%, 14/21 patients). When compared to the non-readmitted patients, diagnosis of OPLL+OFL, circumferential decompression, dural injury, long hospital stay were more to be seen in readmitted patients.Conclusions The incidence of 90-day unplanned readmission after surgical treatment for TSS is 1.7%, CSF leakage and pseudomeningocele were the most common causes of readmission, the peak period of readmission occurred from 10 to 40 days after surgery, patients should be closely followed up within this period.
A phylogenetic framework for the North American bumblebee species of the subgenus Bombus sensu stricto (Bombus affinis, B. franklini, B. moderatus, B. occidentalis &amp; B. terricola) based on mitochondrial DNA markers. (Hymenoptera: Apidae: Bombus).
Authors: Bertsch Andreas , Hrabé de Angelis Martin , Przemeck Gerhard K. H. 
Published: December 2020

Königinnen der vier Taxa Bombus affinis, B. moderatus, B. occidentalis and B. terricola wurden an verschiedenen Orten quer durch Nordamerika gefangen. Zusätzlich wurden Männchen von B. franklini, B. occidentalis und B. terricola gesammelt. Mitochondriale Cytochrome Oxidase Untereinheit I (COI) von 25 Proben wurde sequenziert (Teilsequenzen 1005 bp Länge). Die Divergenz der Sequenzen zwischen den Taxa beträgt 30–50 Basen-Substitutionen und die Tamura-Nei Genetische Distanz 0.05–0.13, während innerhalb der Taxa die Divergenz nur 1 bis 2 Basen-Substitutionen beträgt und die Tamura-Nei Genetische Distanz 0.001–0.002. Da die COI Sequenzen keine Lücken aufweisen, können die einzelnen Nukleotide wie homologe Positionen verwendet werden. Jedes Taxon besitzt 8–20 eigene Substitutionen, die als dia­gnostische Positionen verwendet werden können, um das Taxon zu charakterisieren. Das Phylogramm zeigt drei klar getrennte Cluster: B. moderatus, konspezifisch mit der ostasiatischen B. albocinctus, das Artenpaar B. affinis – B. franklini locker verwandt mit der eurasiatischen B. lucorum, und das Artenpaar B. terricola – B. occidentalis ohne Beziehungen zu irgendwelchen Arten der Alten Welt.
Revision of the Baeoglena species of the West Palaearctic Region (Coleoptera: Staphylinidae: Aleocharinae)
Authors: Assing Volker 
Published: December 2020

The subgenus Baeoglena Thomson, 1867 of the speciose aleocharine genus Oxypoda Mannerheim, 1830 has been subject to considerable taxonomic confusion rendering a reliable identification of material from regions other than Central Europe and the Canary Islands virtually impossible. Based on a revision of abundant material from various major public and private collections, seven species are distributed in the West Palaearctic region exclusive of the Canary Islands. Two new species are described and illustrated: Oxypoda (Baeoglena) rectacia spec. nov. (East Mediterranean, from South Greece to the Middle East) and O. (B.) derecta spec. nov. (West Caucasus, Northeast Anatolia). Diagnoses and illustrations of the genitalia are provided for the remaining five species. The following synonymies are established: Oxypoda nova Bernhauer, 1902 = O. giachinoi Pace, 2001, syn. nov.; O. hispanica Fagel, 1958 and its replacement name O. inexpectata Fagel, 1965 are removed from synonymy with O. praecox Erichson, 1839 and synonymized with O. fusina Mulsant & Rey, 1875. Oxypoda recondita Kraatz, 1856 and O. dalmatina Bernhauer, 1905 are excluded from Baeoglena and moved to the subgenus Bessopora Thomson, 1859. Lectotypes are designated for Oxypoda nova Bernhauer, 1902, O. caucasica Bernhauer, 1902, and O. kuehnelti Scheerpeltz, 1963. An outline of the taxonomic history, a diagnosis of the subgenus, a checklist, and a key to species are provided. A zoogeographic analysis revealed some remarkably discontinuous distributions and parapatric distribution patterns which are plausibly explained only with interspecific competition among Baeoglena species. The distributions of the subgenus as a whole and of the individual species in the West Palaearctic region are mapped.

Taxonomic acts
Oxypoda rectacia spec. nov. – urn:lsid:zoobank.org:act:8E5A6F28-9AD3-474E-99F8-9CBA0F85C4DC Oxypoda derecta spec. nov. – urn:lsid:zoobank.org:act:4C73E05F-20F7-4697-A4BA-D9E030B28A27
A new Scopula from mid-Atlantic Ascension Island (Lepidoptera, Geometridae)
Authors: Karisch Timm , Kramp Katja 
Published: December 2020

The authors report the rediscovery of a Scopula species on Ascension Island. After comprehensive comparison work, it was found to be a species new for science. It is described here as Scopula ascensionis spec. nov. Information on the habitat, larva and pupa are given.

Taxonomic acts
Scopula ascensionis spec. nov. – urn:lsid:zoobank.org:pub:6CA2D311-B23A-4000-9A0A-B0D04EAC27C8
Q wie QVONDAM. Zu zwei Grabinschriften aus dem römischen Köln.
Authors: Kakoschke Andreas 
Published: December 2020

Zusammenfassung:In den römischen Grabinschriften CIL XIII 8356 und 8267b aus Köln muss entgegen der gängigen Meinung der Forschung der Buchstabe Q jeweils als q(uondam) gelesen werden,nicht als Q(uinti filia), <o(bitus)> oder <?>. Die Wendung wurde oftmals mit einem Q wiedergegeben und manchmal zwischen dem Gentiliz und dem Cognomen platziert. Nördlich der Alpen findet sich quondam vor allem in Pannonien. Abstract:In two stone inscriptions from Cologne (CIL XIII 8356 and 8267b) dating to the Romanperiod, one should read Q as q(uondam), instead of Q(uinti filia), <o(bitus)> or <?>. The letter was often written as Q and somtimes placed between the gentilnomen and the cognomen. North of the alps quondam is know especially in Pannonia.
Unbiased estimator modeling in unrelated dichotomous randomized response
Authors: Adediran Adetola Adedamola , Adebola Femi Barnabas , Ewemooje Olusegun Sunday 
Published: December 2020

Abstract
The unrelated design has been shown to improve the efficiency of a randomized response method and reduces respondents’ suspicion. In the light of this, the paper proposes a new Unrelated Randomized Response Model constructed by incorporating an unrelated question into the alternative unbiased estimator in the dichotomous randomized response model proposed by Ewemooje in 2019. An unbiased estimate and variance of the model are thus obtained. The variance of the proposed model decreases as the proportion of the sensitive attribute π_A and the unrelated attribute π_U increases, in contrast to the earlier Ewemooje model, whose variance increases as the proportion of the sensitive attribute increases. The relative efficiency of the proposed model over the earlier Ewemooje model decreases as π_U increases when 0.1≤π_A≤ 0.3 and increases as π_U increases when 0.35≤π_A≤ 0.45. Application of the proposed model also revealed its efficiency over the direct method in estimating the prevalence of examination malpractices among university students;the direct method gave an estimate of 19.0%, compared to the proposed method’s estimate of 23.0%. Hence, the proposed model is more efficient than the direct method and the earlier Ewemooje model as the proportion of people belonging to the sensitive attribute increases.
Flow management system for maximising business revenue and profitability
Authors: Zawada Piotr , Okrasa Włodzimierz , Warchalowski Jack 
Published: December 2020

Abstract
Most for-profit organisations must constantly improve their business strategies and approaches to remain competitive. Many of them choose to embark on Lean or Six Sigma journeys with the intention of maximising productivity and increasing sales. Despite a significant progress in the development of the Big 3 Improvement Methodologies (Lean, Six Sigma, Theory of Constraints – TOC), many manufacturers are still involved in ineffective operations, resulting in longer-than-desired lead times, late deliveries, high inventories and considerable operational costs. All of these business errors seriously challenge the company’s competitiveness. The aim of the paper is to demonstrate the importance of effective analysis of maintaining the appropriate level of inventory in gaining a competitive advantage of the company using the company’s key resources in the competitive struggle on the market while conducting continuous reporting of reasons for not achieving the assumed business goals, and using the principles of the economy of bandwidth in order to maximize the profitability.
Analisis Faktor Penghambat TPACK Subdomain CK dan TPK pada Calon Guru Biologi UNNES
Authors: Uningal Rayi 
Published: December 2020

Abstract Tujuan dari penelitian ini adalah untuk menganalisis dan mendeskripsikan keterlaksanaan praktek mengajar terkait CK dan TPK pada calon guru Biologi UNNES serta mengetahui faktor penghambat kemampuan CK dan TPK sebagai bagian dari kemampuan TPACK pada calon guru Biologi UNNES. Desain penelitian ini adalah deskriptif kuantitatif. Penelitian ini menggunakan instrumen angket Content Representation oleh Loughran et al. Hasil dari penelitian menunjukkan bahwa calon guru biologi UNNES angkatan 2016 banyak memilih materi pada kelas X dan kelas XI karena menganggap merupakan materi yang masih awal, materi dasar dengan tingkat kesulitan yang tidak terlalu besar. Calon guru biologi UNNES lebih menekankan pada penguasaan fakta dan konsep biologi serta kurang terlatih merencanakan pembelajaran biologi yang sesuai dengan hakekat sains. Media pembelajaran yang digunakan berupa media PPT serta melakukan penayangan video dan gambar. Akan tetapi, pemanfaat internet sebagai media belajar oleh calon guru biologi UNNES hanya sebesar 23,50%. Calon guru biologi UNNES belum banyak memiliki pengalaman mengajar, sehingga merasa kurang percaya diri mengintegrasikan teknologi dalam pembelajaran. Kesimpulan dari penelitian ini yaitu calon guru biologi UNNES belum terbiasa untuk menggunakan Kata Kerja Operasional dalam pembuatan tujuan pembelajaran sehingga kurang mampu mengkomunikasikan tuntutan pembelajaran yang sesuai dengan hakekat sains dan kurangnya pengalaman dalam mengajar menyebabkan kurangnya kepercayaan diri dalam mengintegrasikan teknologi.Kata kunci: TPACK, CK, TPK
PENGARUH MODEL PEMBELAJARAN PROJECT BASED LEARNING TERHADAP KEMAMPUAN BERPIKIR KRITIS SISWA PADA MATERI ELEKTROKIMIA
Authors: Zahroh Fathimatuz 
Published: December 2020

Project Based Learning is a learning model that need collaboration from group member in each stage, so that students can develop their critical thinking skills. The aim of this study is to determine the effect of PjBL to students’ critical thinking skills on electrochemistry material. The research design used true experimental design with pretest-posttest control group design and sampling technique is cluster random sampling. The data collection techniques used pretest-posttest to understand 10 critical thinking indicators, observation sheet used to understand students’ project activities and questionnaire to know students’s responses. Data Analysis techniques that used in this study are average difference test, significant test, product moment correlation test, coefficient of determination test. Analysis of product moment correlation value is 0,67 for students’ critical thinking skill with significant test result is 7,10 indicate the significant effect of PjBL to students’ critical thingking skills on electrochemistry material. The effect of PjBL to students’ critical thinking skills pointed by coefficient of determination 44,89%. Based on the results of the study, it was conclude that PjBL had positive effects on students’ critical thinking skills on electrochemistry material.
Adsorpsi Ion Logam Kromium Heksavalen Cr (VI) Dalam Larutan Menggunakan Zeolit Berlapis Oksida Mangan (MnO2)
Authors: Nabiela Maula , Hidayah Malikhatul , Azizati Zidni 
Published: December 2020

<p>Sumber utama pencemaran air dapat berasal dari limbah domestik, industri, pertanian maupun limbah radioaktif yang mengandung berbagai logam beracun dan non-biodegradable seperti Cr, Cu, Pb, Mn, Hg, Cd dll yang dapat terakumulasi dalam organisme hidup dan menyebabkan berbagai macam gangguan penyakit. Ion kromium heksavalen menjadi karsinogen golongan 1 yang diklasifikasikan dengan mekanisme kompleks multipel yang menjadi pemicu perkembangan kanker, Peningkatan tingkat stres oksidatif, kerusakan kromosom, dan pembentukan adduksi DNA. Salah satu metode yang dapat digunakan untuk menyisihkan logam berat seperti Cr adalah menggunakan metode adsorpsi melalui zeolit berlapis oksida mangan. Berdasarkan penelitian yang dilakukan kapasitas adsorpsi terbaik MOCZ pada penyerapan ion logam Cr<sup>6+</sup> diperoleh pada pH 2 dengan waktu kontak 60 menit dengan nilai q<sub>e</sub> = 0,72756 mg/g mengikuti persamaan pseudo orde dua. Secara keseluruhan MOCZ cukup baik dalam mengadsorp ion logam Cr.</p>
Water quality status of groundwater and municipal water supply (tap water) from Bagmati river basin in Kathmandu valley, Nepal
Authors: Bhandari Pabitra , Banjara Megha Raj , Singh Anjana , Kandel Samikshya , Rawal Deepa Shree , Pant Bhoj Raj 
Published: December 2020

Abstract
Poor waste management in the Kathmandu valley has deteriorated the water quality of surface and groundwater sources. The objective of this study was to assess the status of water quality (WQ) in drinking water sources of groundwater and municipal supply (tap water) from the Bagmati river basin in Kathmandu valley. A total of 52 water samples from deep tube-well, tube-well, dug-well, and tap water were collected and analyzed for physical, chemical, and microbiological parameters using standard methods. The results revealed that chloride, total hardness (TH), copper, nitrate, sulfate, and turbidity were within the recommendations of the National Drinking Water Quality Standard (NDWQS). Total coliform (TC) bacteria in 84.6% of the samples exceeded drinking water guidelines. Similarly, the isolates of different enteric bacteria, namely Escherichia coli (21.5%), Citrobacter spp. (20.9%), Klebsiella spp. (19.8%), Proteus spp. (13.9%), Enterobacter spp. (8.72%), Salmonella spp. (5.8%), Shigella spp. (5.2%), and Pseudomonas (4.1%) were identified in the samples collected from the respective sources. Out of the 52 water samples, 7.7% of samples had fecal contamination of somatic coliphage. The groundwater and municipal water supply in the study area are not safe for drinking purposes. Treatment of water is required before its use for household applications.
Developing modules for local storage and handling of cache memory defects information in a processor with non-volatile memory
Authors: Tsoy M. O. , Alfonso D. M. 
Published: December 2020

Problem statement. Due to the downsizing of technological process in microprocessor manufacturing, the number of possible manufacturing defects in the microprocessor chip increases, some types of which can only appear during the main operation of the microprocessor. The hardware implementation of the module for storing and processing information on cache memory defects of the processor with non-volatile memory is considered to neutralize such defects and, as a result, increase the number of usable microprocessors.Objective. Research of various implementation options for such a module, identification of related problems and methods for their solution, synthesis of the described implementation options using computer-aided engineering (CAD) and comparison of the obtained characteristics.Results. The implementation that occupies the smallest area on the chip, intended for implementation in the Elbrus-12C microprocessor under development, was found based on the synthesis results analysis.Practical implications. The paper describes the issues and the way of their solution, taking into account modern requirements for development to increase the number of usable processors.
O potencial de experiência aurática em fotografias em preto e branco
Authors: Boroski Marcia 
Published: December 2020

Este artigo tem como objetivo discutir a partir de quais formas a fotografia em preto e branco (p&b) tem o potencial de proporcionar experiência aurática e, para tanto, fazemos uma discussão teórica sobre os conceitos de fotografia em p&b (FLUSSER, 2018; AUGUSTO; TOUTAIN, 2016; HEDGECOE, 2013), experiência estética (CAETANO, 2013; SANTOS, 2010), efeitos de sentido e de presença (GUMBRECHT, 2010) e experiência aurática (BENJAMIN, 1994, 2014; DIDI-HUBERMAN, 2010), além de propor uma aplicação do debate teórico em fotografias em p&b finalistas do prêmio World Press Photo, as quais consideramos representativas do potencial de experiência aurática. Como resultados, percebemos que a vocação do p&b para expressão do volume e o aprofundamento do espaço contribuem para o seu potencial de experiência aurática.DOI: 10.21882/ruc.v8i15.845 Recebido em: 15/10/2020 Aceito em: 23/11/2020
Maria Immacolata Vassallo de Lopes: os sentidos do popular
Authors: Teixeira Filho Clóvis 
Published: December 2020

Nesta entrevista, a autora faz um breve percurso a partir de sua formação e suas vivências, passando pelos temas relacionados à pesquisa em Comunicação e finaliza com os estudos sobre telenovela. Ainda que o roteiro pareça conhecido para quem acompanha a sua obra, emergem temas transversais como a tecnicidade, as mudanças do consumo midiático e da recepção e até sugestões para futuras pesquisas. Um relato propositivo e instigante aos pesquisadores da Comunicação. DOI: 10.21882/ruc.v8i15.848 Recebido em: 30/10/2020 Aceito em: 30/10/2020
Some characteristics of patients with myelodysplastic syndrome
Authors: Lipilkin P. V. , Shatokhin Yu. V. , Matsuga A. A. 
Published: December 2020

Objective: epidemiological analysis of myelodysplastic syndrome, based on the available retrospective data.Materials and methods: a retrospective analysis of the medical history data of 115 patients (61 men and 54 women) with a diagnosis of myelodysplastic syndrome who received treatment in the hematology department of the «City Hospital № 7 of the city of Rostov-on-Don» in the period from 2010 to 2019.Results: the most likely comorbidities were cardiovascular diseases, which are the main cause of sudden death, and endocrine diseases, which together influence the outcome of myelodysplastic syndrome.Conclusions: there are no individual risk assessment algorithms that could determine the goal setting of therapy in patients with myelodysplastic syndrome, whose life expectancy depends more on the course of concomitant diseases.
The influence of individual genetic polymorphisms on postmenopausal osteoporosis treatment effectiveness
Authors: Reznichenko N. A. , Simrok V. V. , Adunts A. G. 
Published: December 2020

Objective: study of associations between VDR gene rs1544410 and rs10735810 polymorphisms, MCM6 gene rs4988235, CALCR gene rs1801197 one and ibandronate efficacy in women with postmenopausal osteoporosis.Materials and methods: 117 women with postmenopausal osteoporosis were examined for 12 months in the dynamics of treatment with ibandronate. Evaluation of therapy effectiveness was based on indicators of increase in bone mineral density in L1-L4 lumbar vertebrae, as well as left and right femurs.Results: An association of GG genotype of VDR gene rs1544410 polymorphism with low growth rates of mineral density of L1-L4 lumbar vertebrae (3,41 ± 0,60 % versus 5,51 ± 0,78 % in other women; р = 0,036) was established. The effect of other studied polymorphisms (rs10735810 of VDR gene, rs4988235 of MCM6 gene, rs1801197 of CALCR gene) on treatment effectiveness was not found.Conclusion: it is advisable to use obtained results when developing personalized regimens for antiresorptive therapy for women with postmenopausal osteoporosis.