bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women academics in tourism: A cross‐gender study in Turkey
Authors: Aksatan Manolya , Gunlu Ebru , Kozak Metin 
Published: May 2020

AbstractThis study aims to accomplish three objectives: (a) to reveal the reasons why women academics prefer tourism academia; (b) to examine the experiences and perceptions of gender (in)equality of women academics; (c) to determine the cultural, social and family‐based variables affecting the careers of women academics. The study is based on three steps by the application of triangulation method including interviews and focus groups. Study findings suggest that the academia is an attractive environment for women to escape from the industry despite the former brings several problems in taking steps for maintaining their career‐based responsibilities.
Estimating the tourism‐induced province‐specific environmental Kuznets curve: Evidence from panel analyses of Chinese provinces
Authors: Chan Ying Tung , Wong Yat Fung 
Published: May 2020

AbstractThis article estimates province‐specific tourism‐induced environmental Kuznets curve (EKC) in China by using both standard panel data regression and a panel vector error correction model. We validate the EKC hypothesis in the long run but not in the short run, and show that tourism development reduces per capita CO2 inventory. We add to previous research by allowing for heterogeneous impacts of tourism development on CO2 level. Incorporating these heterogeneity effects changes the estimated turning point for EKC significantly. Additionally, it is found that all provinces are still on the increasing part of the EKC, contrasting the existing results.
Whole exome sequencing identifies clinically relevant mutational signatures in resected hepatocellular carcinoma
Authors: Chan Jason Y. , Lim Abner H. , Boot Arnoud , Lee Elizabeth , Ng Cedric C.‐Y. , Lee Jing Y. , Rajasegaran Vikneswari , Liu Wei , Goh Shane , Hong Jing H. , Xu Xiaoying , Bharwani Lavina D. , Chan Chung Y. , Chung Alexander Y. F. , Cheow Peng C. , Tan Chee‐Kiat , Ho Choon K. , Liau Kui H. , Woon Winston W. L. , Low Jee K. , Chopra Akhil , Lopes Gilberto , Rozen Steven G. , Teh Bin T. , Chang Alex Y.‐C. 
Published: May 2020

AbstractBackground & AimsMost patients develop recurrent disease despite curative surgery for hepatocellular carcinoma (HCC). No standard adjuvant therapy is available and molecular predictors of outcome are poorly understood.MethodsWe conducted a multicentre pilot study on patients with localized HCC following surgical resection. Patients received up to 6 months of oral gefitinib as adjuvant therapy. Clinical end points included recurrence‐free survival (RFS) and overall survival (OS), and exploratory analyses were conducted from whole exome sequencing data.ResultsA total of 65 patients were screened for the study, of which 40 were eligible. The median age was 63 years (range, 44‐80). Most patients (80%) were positive for hepatitis B or C. With a median follow‐up of 4.5 years, the median RFS was 24 months. Median OS was not reached. High Child‐Pugh score and advanced T‐stage (3‐4) were independent predictors for both OS and RFS. Mutational signatures for exposure to aristolochic acid (AA), as characterized by a majority of T:A > A:T mutations, were observed in 18 cases (55%). HCC without AA mutagenesis was associated with early recurrences or death within 2 years of surgery (P = .037). HCC with high T > A mutations was associated with better OS (HR 0.29, 95% CI 0.09‐0.90, P = .033). Conversely, HCC with high C > T mutations was associated with worse OS (HR 4.55, 95% CI 1.20‐17.31, P = .026).ConclusionsMutational signatures may carry prognostic significance in HCC following curative resection. Patient outcomes with gefitinib as adjuvant therapy after resection for HCC were modest, highlighting the need for urgent research in this area of unmet clinical need. ClinicalTrials.gov number, NCT00282100.
Polyvinyl Alcohol–Supported AuAgNCs‐CDs Film as a Selective Sensor for Gas Hydrogen Sulfide Detection in Air
Authors: Zhang Chun‐Xia , Li Hong‐Wei , Wu Yuqing 
Published: May 2020

AbstractA novel strategy is reported for the synthesis of glutathione (GSH)‐protected bimetallic nanoclusters, Au‐AgNCs@GSH, and its fabrication with polyvinyl alcohol (PVA) into a film sensor for H2S gas detection. Meanwhile, carbon dots (CDs) synthesized from polyethyleneimine (PEI) are introduced as an internal standard to correct the photobleaching of Au‐AgNCs@GSH and uniformity of film. The joining of it greatly improves the chemical and structural stability of the composite film via multi cross‐linking between PEI, PVA, and GSH. The PVA‐AuAgNCs‐CDs film exhibits an emission‐quenching response to H2S gas at atmosphere, which is highly repeatable, fast, sensitive, and can distinguish H2S from other poisonous gases. Finally, the in‐depth mechanism investigations reveal that the quenching response is attributed to decomposition of Au‐AgNCs@GSH and the formation of Au2S and Ag2S in the composite film. As a sensor, the PVA‐supported film combines the functions of fluorescent metal nanoclusters and polymer CDs, providing a portable device for the rapid detection of H2S gas in air.
A Polydiacetylene‐Based Colorimetric Sensor as an Active Use‐By Date for Plant‐Based Milk Alternatives
Authors: Weston Max , Kuchel Rhiannon P. , Chandrawati Rona 
Published: May 2020

AbstractExisting date marking tools, such as use‐by and sell‐by dates, fail to inform decision‐making throughout food distribution because they do not adapt to storage conditions such as temperature. Polymer‐based sensors can be incorporated into food packaging to provide an indication of food quality in real time, which can greatly reduce waste. This work identifies free fatty acid (FFA) as a marker for the quality of plant‐based milk and demonstrates the first detection tool for the freshness of almond milk using phospholipid‐doped polydiacetylene (PDA) vesicles. The sensor discriminates between triglycerides and FFA by a visible color change and can therefore be used to track fat metabolism during food spoilage. The interaction between FFA and PDA is investigated by electron microscopy and dynamic‐light‐scattering studies. PDA vesicles are then fabricated in agarose and used to discriminate between fresh and spoiled almond milk. Upon exposure of the PDA/agarose sensor to spoiled almond milk, a visible blue‐to‐red color change is induced in the film, which is correlated with FFA concentration in the samples. Incorporation of this technology into food packaging can be used to indicate food quality in real time, surpassing the efficacy of current date marking tools to reduce food waste.
Changes in Regional Cerebral Perfusion Over Time in Idiopathic REM Sleep Behavior Disorder
Authors: Baril Andrée‐Ann , Gagnon Jean‐François , Pelletier Amélie , Soucy Jean‐Paul , Gosselin Nadia , Postuma Ronald B. , Montplaisir Jacques 
Published: May 2020

AbstractBackgroundIdiopathic rapid eye movement sleep behavior disorder is associated with increased risk of neurodegeneration, but the temporal evolution of regional perfusion, a marker of cerebral activity, has not been characterized. The objective of the current study was to study longitudinal regional perfusion in patients with idiopathic rapid eye movement sleep behavior disorder.MethodsThirty‐seven patients and 23 controls underwent high‐resolution single‐photon emission computed tomography. After 17 months on average, scans were repeated for idiopathic rapid eye movement sleep behavior disorder patients. We compared regional cerebral blood flow between groups and over time.ResultsAt baseline, patients showed lower relative regional perfusion in the anterior frontal and lateral parietotemporal cortex compared with controls. However, over time, patients showed an increase in relative regional perfusion in the anterior frontal, lateral parietal, and occipitotemporal cortex, reverting toward normal control levels.ConclusionsPatients with idiopathic rapid eye movement sleep behavior disorder showed significant areas of relative regional hypoperfusion, which disappeared over time to finally return to average levels, suggesting possible developing compensation in areas affected by neurodegeneration. © 2020 International Parkinson and Movement Disorder Society
Stable multiwavelength semiconductor optical amplifier‐based fiber laser using a 2‐mode interferometer
Authors: Ahmad Harith , Azmy Nur Fatini , Aidit Siti Nabila , Zulkifli Mohd Zamani 
Published: May 2020

AbstractA multiwavelength semiconductor optical amplifier (SOA) fiber laser based on all‐fiber two‐mode interferometer (TMI) structure is demonstrated. The TMI generates in a comb‐like spectrum with a 1‐nm wavelength spacing and extinction ratio of 5.7 dB. By incorporating a TMI in the laser cavity, stable multiwavelength operation is obtained with 30 output channels from 1570.8 to 1600.8 nm with peak powers of at least 10 dB from the highest peak. The output comb spectrum and the overall stability of the multiwavelength are also enhanced with by inducing the four‐wave‐mixing effect in the cavity. The multiwavelength SOA fiber laser shows high operational stability with peak power fluctuations exceeding 1 dB observed only at the 1st, 23rd, 26th, and 30th peaks, which are at the ends of the multiwavelength spectrum.
Modeling Larval American Shad Recruitment in a Large River
Authors: Marschall Elizabeth A. , Glover David C. , Mather Martha E. , Parrish Donna L. 
Published: May 2020

Abstract
Climate change is altering the spatial and temporal patterns of temperature and discharge in rivers, which is expected to have implications for the life stages of anadromous fish using those rivers. We developed an individual-based model to track American Shad Alosa sapidissima offspring within a coarse template of spatially and temporally variable habitat conditions defined by a combination of temperature, river velocity, and prey availability models. We simulated spawning at each river kilometer along a 142-km reach of the Connecticut River on each day (April 1–August 31) to understand how spawning date and location drive larval recruitment differentially across years and decades (1993–2002 and 2007–2016). For both temperature and flow, interannual variation was large in comparison to interdecadal differences. Variation in simulated recruitment was best explained by a combination of season-specific spawning temperature and location along the course of the river. The greatest potential recruitment occurred during years in which June temperatures were relatively high. In years when June and July were warmer than average, maximum recruitment resulted from spawning taking place at the upstream portion of the modeled reach. Model scenarios (stationary or passive-drift larvae; and dams or no dams) had predictable effects. We assumed that the pools above dams had negative impacts on eggs and yolk-sac larvae that may have been deposited there. Allowing eggs and larvae to drift passively with the current reduced spatial differences in recruitment success among spawning sites relative to stationary eggs and larvae. Our results demonstrate the importance of spatiotemporal environmental heterogeneity for producing positive recruitment over the long term. In addition, our results suggest the importance of successful passage of spawners to historical spawning sites in the Connecticut River upstream of Vernon Dam, especially as conditions shift with climate change.
Accreditation of nursing clinical services: Development of an appraisal tool
Authors: Poortaghi Sarieh , Salsali Mahvash , Ebadi Abbas , Pourgholamamiji Nima 
Published: May 2020

AbstractAimThis study aimed to determine comprehensive and applicable indicators for assessing the quality of nursing clinical services.DesignMethodological research.MethodsThe checklist was designed in three phases (conceptualization, item generation and item reduction). In the first phase, a qualitative study using conventional content analysis was performed to clarify the concept of accreditation of clinical nursing services. In the second phase, using the views of experts was obtained in phase 1 and then by a review of the literature, related items were extracted, and item pool was formed. In the last phase, validity and reliability of the checklist were examined.ResultBased on three phases (Conceptualization, Item Generation and Item Reduction), the accreditation indicators of clinical nursing services were extracted in three dimensions including structure, process and outcome at two levels of organizational (including structural and outcome indicators) and individual performance appraisal (process indicators) in 19 main categories.
An analytical micromechanics‐based multiscale model for the analysis of functionally graded nanocomposites
Authors: Ghanbari Jaafar , Rashidi Zahra 
Published: May 2020

AbstractAn analytical multiscale model is presented in this article for the analysis of functionally graded nanocomposites. The multiscale scheme is composed of a microscale problem whose solution provides the constitutive model for the macroscale problem. For nanoparticle‐reinforced composites, the microscale problem consists of three phases, namely the nanoparticle, the matrix, and an interphase layer between the matrix and the nanoparticle. An analytical micromechanical model based on Green's function is employed to solve the triple‐phase microscale problem. The homogenized properties of the FG nanocomposite are determined by the micromechanical problem and used in the macroscale level, at every macroscopic material point in which the constitutive model is required. As an example, a nanocomposite beam under bending is considered as the macroscale problem which is investigated by classical, first‐order, and third‐order shear deformation theories. The results obtained from the presented method are compared with the relevant data for similar problems using various higher‐order elasticity theories. By comparing the results of higher‐order theories and those obtained by the presented multiscale method, the internal length parameter of the higher‐order theories is correlated to the volume fraction of the interphase layer between the nanoparticle and the matrix.
Effectiveness of nurse‐led group CBT for hot flushes and night sweats in women with breast cancer: Results of the MENOS4 randomised controlled trial
Authors: Fenlon Deborah , Maishman Tom , Day Laura , Nuttall Jacqueline , May Carl , Ellis Mary , Raftery James , Turner Lesley , Fields Jo , Griffiths Gareth , Hunter Myra S. 
Published: May 2020

AbstractObjectiveTroublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep and quality of life. Cognitive behavioural therapy (CBT) is known to be effective for the alleviation of HFNS. However, it is not known if it can effectively be delivered by specialist nurses. We investigated whether group CBT, delivered by breast care nurses (BCNs), can reduce the impact of HFNS.MethodsWe recruited women with primary breast cancer following primary treatment with seven or more HFNS/week (including 4/10 or above on the HFNS problem rating scale), from six UK hospitals to an open, randomised, phase 3 effectiveness trial. Participants were randomised to Group CBT or usual care (UC). The primary endpoint was HFNS problem rating at 26 weeks after randomisation. Secondary outcomes included sleep, depression, anxiety and quality of life.ResultsBetween 2017 and 2018, 130 participants were recruited (CBT:63, control:67). We found a 46% (6.9‐3.7) reduction in the mean HFNS problem rating score from randomisation to 26 weeks in the CBT arm and a 15% (6.5‐5.5) reduction in the UC arm (adjusted mean difference −1.96, CI −3.68 to −0.23, P = .039). Secondary outcomes, including frequency of HFNS, sleep, anxiety and depression all improved significantly.ConclusionOur results suggest that specialist nurses can be trained to deliver CBT effectively to alleviate troublesome menopausal hot flushes in women following breast cancer in the NHS setting.
Minimal detectable change and reliability of the star excursion balance test in patients with lateral ankle sprain
Authors: Pierobon Andrés , Raguzzi Ignacio , Soliño Santiago , Salzberg Sandra , Vuoto Tomás , Gilgado Daniela , Perez Calvo Eliana 
Published: May 2020

AbstractOBJECTIVELateral ankle sprain (LAS) is one of the most prevalent musculoskeletal injuries in the general population and athletes. Dynamic postural control deficits and somatosensory alterations are common signs after an episode of LAS. It is important to detect these deficits to prevent a recurrent sprain and the development of chronic ankle instability. The Star Excursion Balance Test (SEBT) is a tool used to assess dynamic postural control in patients with LAS. SEBT test–retest reliability has been evaluated in several populations. However, no data on patients with LAS are available and we do not know the minimal detectable change (MDC). The primary objective of our study was to obtain the MDC for normalized reach distances of the eight SEBT directions in patients with LAS. The secondary objective was to determine test–retest reliability.METHODSCross‐sectional study. Thirty‐one patients (between 18 and 40 years old) diagnosed with a Grade I or II LAS. Participants were evaluated by two raters at two time‐points separated by an interval of 24–72 hrs. In each assessment, four practice trials were allowed, then three test trials were performed in a randomized order. Normalized reaching distances were analyzed.RESULTSFrom the initial 31 patients, two were eliminated, so 29 patients were considered for the final analysis. The MDC values obtained were 6.73–13.36%, and the medial and posteromedial directions showed the lowest and highest values, respectively. A statistically significant increase was found in lateral direction between T0 and T1. Intraclass correlation coefficients ranged from 0.72 to 0.93.CONCLUSIONThe SEBT is an accurate and reliable tool to assess dynamic postural control in patients with LAS.
Synthetic Advancement of Neuraminidase Inhibitor “Tamiflu”
Authors: Limbani Bhagirath , Bera Smritilekha , Mondal Dhananjoy 
Published: May 2020

AbstractTamiflu (oseltamivir phosphate), clinically working antiviral chiral drug, is most effective against the infectious disease caused by both influenza A and B. It is also the last resort drug for the treatment of N1H1 virus infection at a high cost with minimal global availability. The current industrial method uses natural (‐)‐shikimic acid obtained from Chinese star anise and coffee beans, hence the limited natural resource and scarcity restricted the Tamiflu production. While most of the synthetic methods reported were composed of natural chiral pools and relatively low‐cost reagents, however, the industrial process is fundamentally limited to the use of hazardous azide or tedious purification methods. In case of an influenza outbreak, producing the Tamiflu according to its demand may be difficult. This document detailed the synthetic progress of chemistry over the last two decades emphasizing the starting materials, hazards of reagents, time needed, number of steps, and overall yields etc. for the interest in academia as well as industrial research.
Mechanism of Action of the Antimicrobial Peptide Caerin1.1
Authors: Houri Aamd J. , Mechler Adam 
Published: May 2020

AbstractCaerin1.1 is a 25‐residue antimicrobial peptide secreted by the tree frog Litoria splendida. It is classified as an α‐helical cationic membrane disrupting peptide, with a good activity against Gram positive bacteria. Given its length, it is believed that caerin1.1 acts via transmembrane pore formation. However, the exact mechanism of its action is unknown. Here the interactions of caerin1.1 with biomimetic membranes were studied to establish the molecular mechanism of action. The activity of the peptide against different model membranes was determined by dye leakage experiments. Caerin1.1 showed weak activity against neat dimyristoyl phosphatidylcholine (DMPC) membrane and minimal activity against negatively charged or cholesterol containing membrane mixtures. Circular dichroism spectroscopy revealed that the peptide exhibited only 8‐16% helicity even in the DMPC membrane, yet quartz crystal microbalance fingerprinting suggested that the peptide was able to penetrate the membrane in each case. The results suggest that caerin1.1 is a membrane penetrating peptide but not a membrane disruptor, only causing incidental dye leakage while diffusing across the membrane. Consistently the main mode of action of caerin1.1 is likely exerted through an intracellular target.
Fluorescent pH‐Responsive Mesoporous Silica Nanoparticles with Core‐Shell Feature as a Traceable Delivery Carrier for Ibuprofen
Authors: Wei Tingting , Sheng Mengdi , Liu Chang , Sun Jihong , Wu Xia , Bai Shiyang 
Published: May 2020

AbstractThe fluorescent pH‐responsive mesoporous silica nanoparticles (P@BMMs) were prepared, in which, the (2‐[3‐(triethoxysilyl) propyl]‐1H‐Benz [de]isoquinoline‐1, 3(2H)‐dione) ‐ poly(acrylic acid) (PID‐PAA) shell was covalently anchored onto the vinyl‐modified surface of the bimodal mesoporous materials (BMMs) core via one‐step or two‐step process. Their structural features were analyzed by XRD, SEM, TEM, TG, and SAXS, and the results showed that P@BMMs possessed typical fractal features from structural irregularity to surface roughness. Ibuprofen as a model drug was loaded into the mesopore channels of BMMs cores, particularly, the drug‐releasing performances from P@BMMs carriers were pH‐dependent. Meanwhile, the photoluminescent emission spectra and the fluorescent decay profiles presented that the hybrid P@BMMs with strong fluorescent intensity at 395 nm and 450 nm and longer decay lifetimes (such as 3.53 and 18.86 ns for P@BMMs‐I‐10) is a promising drug carrier, which can be used in potential applications for controlled drug delivery.
A Naked Eye and Turn‐On Fluorescence Detection of Zn2+ Ion by Imidazole‐Quinoline‐Based Fluorophore and Its Application in Live‐Cell Imaging
Authors: Gavash Harsha Kannikanti , Madhu Chakali , Puvvada Nagaprasad , Ramachandra Rao Baggi Tulsidas , Jayathirtha Rao Vaidya , Reddy Chereddy Narendra 
Published: May 2020

AbstractA novel quinoline‐imidazole hybrid conjugate chromophore, 2‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)‐4‐phenylquinoline (DIPQ), is designed, synthesized, characterized using NMR, ESI‐MS and ESI‐HRMS analyses and explored for its ability in detecting a range of biologically relevant cations. Among the various metal ions, DIPQ responds selectively to the addition of Zn2+ with a change in color from colorless to pale yellow along with characteristic green fluorescence at 564 nm. Zn2+ induced absorption and fluorescence changes of DIPQ are not affected by other commonly coexistent metal ions and anions. DIPQ‐Zn2+ binding interactions are thoroughly studied using NMR and MALDI‐MS analyses. DIPQ is capable to detect Zn2+ even at the nano‐molar levels with a limit of detection (LOD) and limit of quantification (LOQ) of 2.7×10−8 M and 8.1×10−8 M, respectively. Sample matrices have trivial impact on the Zn2+ detection ability of DIPQ. The quantitative results obtained from the DIPQ method are comparable with the ICP‐OES method. Moreover, DIPQ has a wide pH range of operation, exhibited good cell permeability and low toxicity for biological applications. Furthermore, DIPQ is suitable to detect Zn2+ ions present in biological tissues.