bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxychloroquine-Induced Stevens-Johnson Syndrome in COVID-19: A rare Case Report
Authors: Davoodi Lotfollah , Jafarpour Hamed , Kazeminejad Armaghan , Soleymani Eissa , Akbari Zahra , Razavi Alireza 
Published: May 2020

Abstract
Background: The international outbreak of respiratory illness termed coronavirus disease 2019 (COVID-19) began in December 2019 that has affected more than 0.8 million individuals. To date, there are no specific therapeutic agents for coronavirus infections. One of the drugs that have an effective role in improving the condition of patients with COVID-19 is hydroxychloroquine (HCQ). This drug is not a definitive treatment for this disease and has a supportive role. Like all medications, HCQ has side effects and may occur in COVID-19 patients. Stevens-Johnson syndrome caused by HCQ is very rare.Case presentation: A 42-year-old woman, presented with fever and dry cough in the past two days to her family physician. Lab tests revealed elevated lactate dehydrogenase (LDH, 648 units/liter (U/L)), C-reactive protein level (CRP, 52 milligrams/Liter (mg/L), normal: <10 mg/L), aspartate aminotransferase (AST, 59 U/L, normal: 10-40 U/L), thrombocytopenia, and leukopenia. Mild bilateral patchy ground-glass opacity was seen in lung CT-Scan. Due to COVID-19 pandemic and clinical findings, the nasopharyngeal swab test was done and SARS-CoV-2 nucleic acid was detected by RT-PCR. HCQ 200 mg twice daily was started. After two days, the patient presented with a pruritic erythematous maculopapular rash and ﬂat atypical targets that started from the distal of upper extremities and rapidly, involved the entire body, and torn blisters which were only be seen as ulcers on orolabial area. The Nikolsky sign was positive. Due to the likelihood of a drug reaction, HCQ was discontinued, and COVID-19 treatment was changed to lopinavir/ritonavir (LPV/RTV) 400 mg twice daily. Finally, she was discharged after five days with nonpruritic scalded skin on the distal of upper extremities. Conclusions: It is worth noting that although HCQ appears to be safe and has mild side effects, however, the boundary between therapeutic and toxic doses is narrow and severe disorders of their use can life-threatening. One of the side effects of HCQ is SJS caused by the drug, and given the worldwide pandemic of COVID-19 and the increasing need for this drug, we need to be careful about its use in order to control and manage the side effects of this drug.
Association between ibuprofen exposure and severe COVID-19 infection: a nationwide register-based study
Authors: Kragholm Kristian , Gerds Thomas A. , Fosbøl Emil , Andersen Mikkel Porsborg , Phelps Matthew , Butt Jawad H. , Østergaard Lauge , Gislason Gunnar , Schou Morten , Køber Lars , Torp-Pedersen Christian 
Published: May 2020

Abstract
Background: Initially, the World Health Organization (WHO) and national health boards issued a warning against NSAID use in corona virus disease 2019 (COVID-19) patients and recommended that paracetamol or acetaminophen instead should be administered. However, later and current WHO and European Medicine Agency recommendations do not call for avoidance of ibuprofen in COVID-19 patients. Given the current uncertainty of drug safety for NSAID use in patients with COVID-19, we performed a nationwide register-based study on the association of recent ibuprofen exposure and COVID-19 severity.Methods: Using national administrative databases, we identified COVID-19 patients in Denmark between end of February 2020 and April 2, 2020. Patients <30 years of age and heart failure, for whom ibuprofen is not recommended, were excluded. Ibuprofen exposure was defined using the Danish National Prescription Registry, where we had information until January 31, 2020. Endpoint was a composite of severe COVID-19 diagnosis with acute respiratory syndrome, intensive care unit admission or death. Results: Among 1,872 patients, 46 (2.5%) were exposed to ibuprofen prior to COVID-19 infection. Patients with recent ibuprofen exposure tended to be older and more likely to have hypertension, diabetes, myocardial infarction, chronic obstructive pulmonary disease, and cancer, though all insignificant (P>0.05). When adjusting for these covariates, odds ratio was 1.57 [95% CI 0.72-3.38], with 12 ibuprofen-exposed patients meeting the endpoint (26.1% [95% CI 13.4-38.8%]) versus 272 unexposed patients (14.9% [95% CI 13.4-16.4%]), P=0.15. Conclusion: The association between ibuprofen and severe COVID-19 was insignificant, although with a trend towards increased disease severity risk.
ANALISIS PREDIKSI FINANCIAL DISTRESS DENGAN METODE SPRINGATE (S-SCORE) PADA PT GARUDA INDONESIA TBK
Authors: Fitriani Marisa , Huda Nurul 
Published: May 2020

Abstrak: Analisis Prediksi Financial Distress Dengan Metode Springate (S-Score) Pada PT Garuda Indonesia Tbk Penelitian ini bertujuan untuk mengetahui seberapa besarnya prediksi financial distress dan potensi kebangkrutan pada PT Garuda Indonesia Tbk. Jenis penelitian deskriptif kuantitatif. Populasi yang digunakan adalah laporan keuangan PT Garuda Indonesia Tbk yang diakses melalui website www.idx.co.id dalam bentuk laporan neraca (posisi keuangan) dan laba rugi selama delapan tahun terakhir yaitu tahun 2011-2018. Teknik sampling yang digunakan yaitu teknik purposive sampling dengan memperoleh sampel selama tujuh tahun terakhir yaitu tahun 2012-2018. Teknik analisis yang digunakan yaitu metode Sprigate Score (S-score) yang menggunakan empat rasio yaitu rasio modal kerja terhadap total aset (X1), rasio laba sebelum bunga dan pajak terhadap total aset (X2), rasio laba sebelum pajak terhadap total liabilitas (X3), dan rasio penjualan terdapap total aset (X4) serta menggunakan uji t-test one sample. Hasil penelitian ini diperoleh nilai thitung lebih kecil dari pada ttabel (-3.628<1.943). sehingga hipotesis Ho yang berbunyi yaitu: Sprigate Score (S-Score) pada PT Garuda Indonesia Tbk kurang dari 0.862 dari yang diharapkan diterima yang artinya bahwa PT Garuda Indonesia, Tbk dikategorikan dalam kondisi financial distress dan berpotensi mengalami kebangkrutan selama tujuh tahun terakhir yaitu dari tahun 2012-2018.Kata Kunci: Financial Distress, Kebangkrutan, Springate Score.
Modifications to Electronic Nicotine Delivery Systems: Content Analysis of YouTube Videos
Authors: Massey Zachary B , Li Yachao , Holli Jessica , Churchill Victoria , Yang Bo , Henderson Katherine , Ashley David L , Huang Jidong , Popova Lucy 
Published: May 2020

Background
As user modification can alter the addictiveness and toxicity of electronic nicotine delivery systems (ENDS), more research is needed to understand the types, motivations, risks, and information sources that lead to these product alterations. YouTube has been identified as a major platform where ENDS users obtain and share information about ENDS products and modifications. However, a comprehensive study of ENDS modification videos on YouTube is lacking.

Objective
This study aimed to analyze the content of YouTube videos depicting modifications of ENDS.

Methods
YouTube was searched in March 2019 to identify videos depicting ENDS modifications. Search terms were derived from interviews with ENDS users and current literature. We used 28 search phrases that combined the words vape and vaping with modification-related key terms (eg, custom build, modification, and dripping). The final sample included 168 videos.

Results
Videos were 1 to 108 min long (median 9.55). Presenters were largely male (117/168, 69.6%), white (94/168, 56.0%), and older than 25 years (94/168, 56.0%). Most videos gave how to instructions (148/168, 88.1%), but few offered warnings (30/168, 17.9%) or mentioned commercial alternatives to modifications they presented (16/168, 9.5%). The ENDS devices most often featured were drippers (63/168, 37.5%) and refillable tanks (37/168, 22.0%). The most often modified ENDS components were coils (82/168, 48.8%) and e-liquids (34/168, 20.2%), which included adding other substances, such as cannabis, to the e-liquids (6/168, 3.6%). Most videos portrayed ENDS modifications positively (106/168, 63.1% positive; 60/168, 35.7% neutral; and 2/168, 1.2% negative) and were either neutral or positive in their overall portrayal of ENDS devices (78/168, 46.4% positive; 89/168, 53.0% neutral; and 1/168, 0.6% negative).

Conclusions
This study identified several concerning trends in popular YouTube videos on ENDS modifications, including lack of warnings, the addition of marijuana derivatives to e-liquids, and the positive portrayal of ENDS devices and modifications. By identifying the types of modifications (coil and e-liquid being the most prevalent), this study sets an agenda for research on the effects of modifications.
The Stages of Drug Discovery and Development Process
Authors: Deore Amol B , Dhumane Jayprabha R , Wagh Rushikesh , Sonawane Rushikesh 
Published: May 2020

Drug discovery is a process which aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the process of drug development earlier to clinical trials. New drug development process must continue through several stages in order to make a medicine that is safe, effective, and has approved all regulatory requirements. One overall theme of our article is that the process is sufficiently long, complex, and expensive so that many biological targets must be considered for every new medicine ultimately approved for clinical use and new research tools may be needed to investigate each new target. From initial discovery to a marketable medicine is a long, challenging task. It takes about 12 - 15 years from discovery to the approved medicine and requires an investment of about US $1 billion. On an average, a million molecules screened but only a single is explored in late stage clinical trials and is finally made obtainable for patients. This article provides a brief outline of the processes of new drug discovery and development.
Considerações sobre o processo de gestão e controle de estoque de merenda escolar realizado em uma instituição de ensino da cidade de São Paulo
Authors: Gonçalves Luiz Claudio , Dos Santos Gabriela , De Lima Valter Paulo 
Published: May 2020

Um estoque bem gerido e organizado evita altos custos de manutenção e de falta de produtos. Com base nesses argumentos, esta investigação busca identificar quais são as atividades executadas no processo de gestão e controle de estoque de merenda escolar e, também, quais são as vantagens e desvantagens trazidas por ele para uma instituição de ensino situada na cidade de São Paulo. Como resultados obtidos na pesquisa, observa-se que a instituição faz uso de algumas técnicas e ferramentas descritas na pesquisa, visando auxiliam na melhoria do processo, diminuindo assim, o índice de faltas de produtos. Verificou-se também que, após a implantação do sistema informatizado SAESP, a instituição consegue maior e melhor autonomia para gerenciar o seu cardápio. No atual cenário competitivo, definir métodos efetivos de gestão e controle de estoque torna-se um grande diferencial para que as empresas possam ser competitivas e assim obterem o devido reconhecimento do mercado. Nesse cenário, tanto o gestor quanto sua equipe devem procurar reduzir custos, otimizar tempo e espaço, evitar desperdícios, executar a identificação e disposição adequada de produtos e controlar a sua rotatividade.
MicroRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia
Authors: Spinetti Gaia , Sangalli Elena , Tagliabue Elena , Maselli Davide , Colpani Ornella , Ferland-McCollough David , Carnelli Franco , Orlando Patrizia , Paccagnella Agostino , Furlan Anna , Stefani Piero Maria , Sambado Luisa , Sambataro Maria , Madeddu Paolo 
Published: May 2020

OBJECTIVE
In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34+ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker.

RESEARCH DESIGN AND METHODS
The association between CD34+ cell migration and cardiovascular mortality was reassessed at 6 years after revascularization. In a new series of T2D-CLI and control subjects, immuno-sorted bone marrow CD34+ cells were profiled for miRNA expression and assessed for apoptosis and angiogenesis activity. The differentially regulated miRNA-21 and its proapoptotic target, PDCD4, were titrated to verify their contribution in transferring damaging signals from CD34+ cells to endothelial cells.

RESULTS
Multivariable regression analysis confirmed that CD34+ cell migration forecasts long-term cardiovascular mortality. CD34+ cells from T2D-CLI patients were more apoptotic and less proangiogenic than those from control subjects and featured miRNA-21 downregulation, modulation of several long noncoding RNAs acting as miRNA-21 sponges, and upregulation of the miRNA-21 proapoptotic target PDCD4. Silencing miR-21 in control CD34+ cells phenocopied the T2D-CLI cell behavior. In coculture, T2D-CLI CD34+ cells imprinted naive endothelial cells, increasing apoptosis, reducing network formation, and modulating the TUG1 sponge/miRNA-21/PDCD4 axis. Silencing PDCD4 or scavenging reactive oxygen species protected endothelial cells from the negative influence of T2D-CLI CD34+ cells.

CONCLUSIONS
Migration of CD34+ cells predicts long-term cardiovascular mortality in T2D-CLI patients. An altered paracrine signaling conveys antiangiogenic and proapoptotic features from CD34+ cells to the endothelium. This damaging interaction may increase the risk for life-threatening complications.
Oral hygiene status students of Faculty of Dentistry Universitas Padjadjaran batch 2007 and 2011
Authors: Arista Stevi Mega , Wardani Riana , Suwargiani Anne Agustina 
Published: May 2020

Introduction: Oral hygiene could be influenced by four factors, there are enviromental, behavior, health service, and hereditery factors. The mayor factors are enviromental and behavior factors. Behavior factors influenced by the level of education a person which affect to the status of individual oral hygiene. The aim of this research was to describe oral hygiene status on students at Faculty of Dentistry, Universitas Padjadjaran class of 2007 with class of 2011. Methods: This type of research was descriptive research using the survey method were obtained through clinical examination. The sampel were collected by way of proportional sampling and samples were 142 students. Results: Oral hygiene index of students of Faculty of Dentistry, Universitas Padjadjaran class of 2007 to be 0,62. The result of this research indicated that the oral hygiene index of students of Faculty of Dentistry, Universitas Padjadjaran class of 2011 to be 1,19. Conclusion: Oral Hygiene status of students of Faculty of Dentistry Universitas Padjadjaran class of 2007 were in the good category and the Oral Hygiene Index of students of Faculty of Dentistry Universitas Padjadjaran class of 2011 were in the medium category.
Correlation between dental anxiety and salivary pH prior to the tooth extraction
Authors: Stefani Stacia , Tjahajawati Sri 
Published: May 2020

Introduction: Dental anxiety can be one of inhibiting faktor in dental care that must be immediately detected and handled by dentists. Dental anxiety can cause physiological changes such as reduced salivary secretion that can cause reduced salivary pH. The aim for this study is to find correlation between dental anxiety and salivary pH, so that salivary pH can be one of indicator of dental axiety. Methods: This descriptive analytic study used consecutive sampling technique and was analyzed by Rank Spearman correlation test. Dental anxiety and salivary pH was measured in 53 respondents before tooth extraction using Corah’s Dental Anxiety Scale and pH paper. Results: The results from this study show that respondents with dental anxiety have lower average salivary pH. Statistic calculation using Rank Spearman correlation test with α =5%, shows cofficient correlation rs =0.438 with t = 3.479 and ta/2(n-2) = 2.008. Conclusion: The conclusion from this study shows that there is a correlation between dental anxiety and salivary pH before tooth extraction.
Comparison of intercanine width in between Angle class II division 1 and division 2 malocclusions
Authors: Putri Bebby , Malik Isnaniyah , Zenab N R Yuliawati 
Published: May 2020

Introduction: Dental arch width measurement is needed to determine diagnoses and orthodontic treatment planning of Angle Class II Division 1 and Class II Division 2 malocclusions that have narrow maxillary dental arch generally. Dental arch width in this study was measured by maxillary and mandibular intercanine width. This study aimed to compare the differences of intercanine width between Angle Class II division 1 and Class II division 2 malocclusions. Methods: Descriptive comparative research with total samples of 67 study models, consisted of 34 Class II division 1 cases and 33 Class II division 2 cases. The minimum age of the samples chosen was 13 years old with no history of orthodontic treatment. A non probability consecutive sampling technique was used. Results: Study results showed the avarage maxillary and mandibular intercanine width of Class II Division 1 were 33,99 mm and 26,33 mm. Average maxillary and mandibular intercanine width of Class II Division 2 were 34,77 mm and 25,37 mm. Conclusions: T-test analysis showed no statistical significant differences in the intercanine width between Angle Class II Division 1 and Class II Division 2 malocclusions.
EXPERIMENTAL INVESTIGATION ON DRYING OF BLANCHED BITTER GOURD SLICES IN A TRIPLE PASS SOLAR DRYER
Authors: Kesavan S. , Arjunan T.V. , Vijayan S. 
Published: May 2020

This paper involves with the experimental performance study of a triple pass solar flat plate collector integrated withÂ thermal energy storage medium for drying of blanched bitter gourd slices. The experimental setup consists of a blower, triple pass flat plate collector and a drying chamber. The experimets were carried out in the meterological conditions of Coimbatore, Tamil Nadu, India. The mass flow rate of air through the system was set as 0.06 kgs-1. From the results, it could be comprehended that, (i) triple pass arrangement of air improves the performance of flat plate collector (ii) thermal energy storage medium played an important role in consistent outlet air temperature and the thermal efficiency (iii) triple pass solar dryer took 5 hours to reach the final moisture content of bitter gourd (9% on wet basis) which is 29 % and 37.5% faster than without thermal storage and open sun drying system. It could be concluded that triple pass solar air collector performs better than without thermal storage and open sun drying.
EXPERIMENTAL STUDY ON MECHANICAL AND DURABILITY PROPERTIES OF HIGH PERFORMANCE CONCRETE REPLACING COARSE AGGREGATE BY FERRO SLAG AGGREGATES
Authors: Soundararajan M. , Kumar K.Nirmal 
Published: May 2020

The main objective of this research is to find out alternative materials for concrete to meet the demands of coarse aggregate for the upcoming years, to provide adequate strength at minimum cost, to make the eco-friendly structures.Â Use of ferro slag a waste industrial by-product of iron and steel production provides great opportunity to utilize it as an alternative to normally available aggregates (coarse). In this research, ferro slag is used and M60 grade concrete ofÂ W/C ratio 0.28 was used respectively for the replacement of 0 to 100% coarse aggregate by ferro slag aggregate for find out the optimum ratio of steel slag. In this study, a mix ratio of 1: 1.2: 2.4 is used in conventional mix. Initial optimization ofÂ ferro slag aggregate for replacing the natural coarse aggregate was find with 7and 28 days strength. Test on compressive strength and non-destructive test at 7 and 28 days were conducted. It was concluded that possible optimum replacement of slag material was found to be 40%. Split Tensile Strength and Flexural Strength and durability characteristics were carried out for conventional and optimum concrete mix to study the properties of concrete with ferro slag.
The Computation of Residual and Regional Anomaly of Gravity Method Data By Polynomial Filter Using Microsoft Excel
Authors: Muhajirin Muhajirin , Ismail Nazli , Bukhari Bukhari 
Published: May 2020

Eksplorasi metode gravitasi umumnya dilakukan untuk mencari objek di bawah permukaan yang dangkal sehingga perlu dilakukan pemisahan anomali residual dan regional dari anomali Bouguer lengkap. Perhitungan anomali residual biasanya menggunakan software khusus untuk pengolahan data geofisika yang berlisensi atau algoritma dengan bahasa pemrograman, sedangkan program Microsoft Excel pada PC dan notebook biasa digunakan untuk perhitungan polinomial pada pengolahan data statistik. Penelitian ini memperkenalkan cara menghitung anomali residual menggunakan Microsoft Excel dengan filter polinomial. Hasil validasi yang menggunakan model sintetik menunjukkan bahwa perhitungan tersebut dapat diaplikasikan pada data metode gravitasi. Aplikasi pada data lapangan diperoleh bahwa anomali residual berfrekuensi tinggi, sedangkan anomali regional berfrekuensi rendah. Nilai anomali regional dipengaruhi oleh trendline anomali Bouguer lengkap dalam domain jarak. Hasil ini relatif sama dengan hasil perhitungan software lainnya. Gravity method exploration was generally conducted to seek the object in shallow underground so that required residual and regional anomaly separation of complete Bouguer anomaly. The residual anomaly separation was usually used by the special softwares for geophysics that require licency or algorithm by programming language, however the program of Microsoft Excel in the PC or notebook was usually applied to compute the polynomial filter for statistic data analysis. This research introduces how to compute residual anomaly using Microsoft Excel through polynomial filter. The validation result of sintetic model shows that the computation using Microsoft Excel can be applied to gravity method data. The application of field data was obtained that residual anomaly has high frecuency, whereas residual anomaly has low frecuency. The value of regional anomaly was influenced by trendline of complete Bouguer anomaly in distance domain. This result relatively equals to the result of other softwares. Keywords: gravity method, residual anomaly, regional anomaly, polynomial filter, Microsoft Excel