bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Comparison of Flow Boiling Heat Transfer in High Aspect Ratio Microchannels With Plain and Grooved Walls
Authors: Cheng Xiao , Wu Huiying 
Published: August 2020

Abstract
The dry-out easily occurs on high-aspect ratio microchannel sidewalls due to the decreasing of liquid film thickness. In this paper, the triangular microgrooves possessing the characteristic of evaporating meniscus were designed on the microchannel sidewalls. The heat sink consisted of 33 parallel microchannels, having a hydraulic diameter of 100 μm and an aspect ratio of 4. A platinum film heater and platinum resistance temperature detectors (RTDs) were integrated on the backside of the heat sink to realize uniform heating and precise temperature measurement, respectively. Flow boiling visualization experiments were carried out by high-speed camera in triangular groove-wall and plain-wall microchannels at mass fluxes of 148–490 kg/m2·s and inlet temperatures of 42 °C and 60 °C. The boiling curve, heat transfer coefficient (HTC), pressure drop, and two-phase flow boiling instability were systematically investigated to assess the flow boiling performances. Thin liquid film was observed in the triangular grooves during the dry-out process, compared to the dry-out in plain-wall microchannels. The oscillations of wall temperature, inlet temperature, and pressure drop were significantly suppressed in triangular groove-wall microchannels. Moreover, the earlier onset of nucleate boiling, improved heat flux, and HTC were realized in triangular groove-wall microchannels compared to plain-wall microchannels. Therefore, triangular groove design on the sidewalls is a promising solution to enhance boiling heat transfer and suppress flow boiling instabilities for high-aspect ratio microchannels.
Comparison of Ellipsoidal and Equivalent Torispherical Heads Under Internal Pressure: Buckling, Plastic Collapse and Design Rules
Authors: Zheng Jinyang , Yu Yehong , Chen Yehong , Li Keming , Zhang Zekun , Peng Wenzhu , Gu Chaohua , Xu Ping 
Published: August 2020

Abstract
Ellipsoidal and torispherical heads, whose geometric shapes are close, are usually used as end closures of internally pressurized vessels. In pressure vessel codes, for example, ASME BPVC Section VIII and EN13445-3, ellipsoidal heads are designed as torispherical heads using geometric equivalency approaches. However, the difference between ellipsoidal and equivalent torispherical heads has not been studied in detail. In this paper, we first investigate shape deviation between the two types of heads. Then we compare elastic–plastic behaviors between ellipsoidal and equivalent torispherical heads as well as their failure modes, i.e., buckling and plastic collapse (bursting). It is found that ellipsoidal heads have more buckling resistance than equivalent torispherical heads, indicating that the current design rules for buckling of ellipsoidal heads based on the geometric equivalency approaches result in uneconomical design. In addition, experimental and numerical results show that such heads experience geometric strengthening. The finite element (FE) method considering the effect of geometric strengthening provides a good prediction of plastic collapse pressure. However, the current design equation for bursting does not consider the effect of geometric strengthening, also leading to uneconomical design. Therefore, in order to avoid uneconomical design, we recommend that (1) with respect to buckling of ellipsoidal heads, a new design equation be proposed rather than implementing the geometric equivalency approaches, and (2) the current design equation for bursting be deleted, and a new design equation, considering the effect of geometric strengthening, be proposed for bursting of ellipsoidal and torispherical heads.
Transient Response of Linear Systems Under Integral Constraints
Authors: Salih Bilal , Das Tuhin 
Published: August 2020

Abstract
The requirement of satisfying an integral constraint imposed on a linear system's transient step-response is considered in this paper. The problem is first analyzed to determine the specific structure of a system's transfer function that helps satisfy such constraints. Analytical results are derived for a class of second-order systems with an additional zero. The results are extended to higher order transfer functions. Subsequently, a standard compensation consisting of a combination of feedforward and feedback actions is proposed to transform a given transfer function to the desired structure. Necessary and sufficient conditions to guarantee stability of the resulting closed-loop system are derived. Next, the problem of satisfying integral constraints in the presence of parametric uncertainty is addressed by augmenting adaptive estimation strategies to the feedforward and feedback compensation structure. Simulation results are provided for validation. The theory presented here is an abstraction from power management algorithms for hybrid power systems, such as a fuel cell hybridized with an ultracapacitor. Further work is ongoing to extend the theory to nonlinear systems.
Vertical Jump Testing in Rugby League: A Rationale for Calculating Take-Off Momentum
Authors: McMahon John J. , Lake Jason P. , Ripley Nicholas J. , Comfort Paul 
Published: August 2020

The purpose of this study was to determine the usefulness of calculating jump take-off momentum in rugby league (RL) by exploring its relationship with sprint momentum, due to the latter being an important attribute of this sport. Twenty-five male RL players performed 3 maximal-effort countermovement jumps on a force platform and 3 maximal effort 20-m sprints (with split times recorded). Jump take-off momentum and sprint momentum (between 0 and 5, 5 and 10, and 10 and 20 m) were calculated (mass multiplied by velocity) and their relationship determined. There was a very large positive relationship between both jump take-off and 0- to 5-m sprint momentum (r = .781, P < .001) and jump take-off and 5- to 10-m sprint momentum (r = .878, P < .001). There was a nearly perfect positive relationship between jump take-off and 10- to 20-m sprint momentum (r = .920, P < .001). Jump take-off and sprint momentum demonstrated good–excellent reliability and very large–nearly perfect associations (61%–85% common variance) in an RL cohort, enabling prediction equations to be created. Thus, it may be practically useful to calculate jump take-off momentum as part of routine countermovement jump testing of RL players and other collision-sport athletes to enable the indirect monitoring of sprint momentum.
Are the Current Cardiac Rehabilitation Programs Optimized to Improve Cardiorespiratory Fitness in Patients? A Meta-Analysis
Authors: Manresa-Rocamora Agustín , Sarabia José Manuel , Sánchez-Meca Julio , Oliveira José , Vera-Garcia Francisco Jose , Moya-Ramón Manuel 
Published: August 2020

Previous meta-analyses have shown that high-intensity interval training (HIIT) is more suitable than moderate continuous training (MCT) for improving peak oxygen uptake (VO2peak) in patients with coronary artery disease. However, none of these meta-analyses have tried to explain the heterogeneity of the empirical studies in optimizing cardiac rehabilitation programs. Therefore, our aims were (a) to estimate the effect of MCT and HIIT on VO2peak, and (b) to find the potential moderator variables. A search was conducted in PubMed, Scopus, and ScienceDirect. Out of the 3,110 references retrieved, 29 studies fulfilled the selection criteria to be included in our meta-analysis. The mean difference was used as the effect size index. Our results showed significant enhancements in VO2peak after cardiac rehabilitation based on MCT and HIIT (mean difference = 3.23; 95% confidence interval [2.81, 3.65] ml·kg−1·min−1 and mean difference = 4.61; 95% confidence interval [4.02, 5.19] ml·kg−1·min−1, respectively), with greater increases after HIIT (p < .001). Heterogeneity analyses reached statistical significance with moderate heterogeneity for MCT (p < .001; I2 = 67.0%), whereas no heterogeneity was found for the effect of HIIT (p = .220; I2 = 22.0%). Subgroup analyses showed significant between-group heterogeneity of the MCT-induced effect based on the training mode (p < .001; I2 = 90.4%), the risk of a new event (p = .010; I2 = 77.4%), the type of cardiovascular event (p = .009; I2 = 84.8%), the wait time to start cardiac rehabilitation (p = .010; I2 = 76.6%), and participant allocation (p = .002; I2 = 89.9%). Meta-regressions revealed that the percentages of patients undergoing a revascularization procedure (B = −0.022; p = .041) and cardiorespiratory fitness at baseline (B = −0.103; p = .025) were inversely related to the MCT-induced effect on the VO2peak.
Stress in the tropics? Impact of a latitudinal seawater δ18O gradient on Middle Jurassic temperature reconstructions at low latitudes
Authors: Alberti Matthias , Leshno Yael , Fürsich Franz T. , Edelman-Furstenberg Yael , Andersen Nils , Garbe-Schönberg Dieter 
Published: August 2020

Abstract
Previous stable oxygen isotope records of calcitic fossils (δ18Oshell) from Europe have been interpreted to reflect strong climatic perturbations throughout the Jurassic, but it is unknown whether they reflect global trends because data from other regions are sparse. Here, we use bivalve and brachiopod shells from western Asia and northern Africa to examine seawater temperatures at low latitudes as well as latitudinal temperature gradients in the Middle Jurassic. Our results include the first absolute temperature estimates for most of the study areas and this time interval. Furthermore, we acknowledge a latitudinal gradient in δ18O values of seawater (δ18Osea) that leads to more realistic temperature reconstructions of tropical water temperatures, which were underestimated by earlier methods. Following this approach, δ18Oshell values translate into average equatorial water temperatures during the Middle Jurassic several degrees higher than today (as high as 34–35 °C). Such high temperatures cause environmental stress, probably explaining previously documented low diversities of low-latitudinal ecosystems (e.g., coral reefs) during this time interval. A comparison with literature data raises doubts over whether previously published European temperature curves are truly representative of global patterns. Instead, they might reflect the complex paleogeography of European basins influenced by regional and/or short-term changes in δ18Osea values.
Late Miocene contourite channel system reveals intermittent overflow behavior
Authors: de Weger Wouter , Hernández-Molina F. Javier , Flecker Rachel , Sierro Francisco J. , Chiarella Domenico , Krijgsman Wout , Manar M. Amine 
Published: August 2020

Abstract
Paleoceanographic information from submarine overflows in the vicinity of oceanic gateways is of major importance for resolving the role of ocean circulation in modulating Earth’s climate. Earth system models are currently the favored way to study the impact of gateways on global-scale processes, but studies on overflow-related deposits are more suitable to understand the detailed changes. Such deposits, however, had not yet been documented in outcrop. Here, we present a unique late Miocene contourite channel system from the Rifian Corridor (Morocco) related to the initiation of Mediterranean Outflow Water (MOW). Two channel branches were identified consisting of three vertically stacked channelized sandstone units encased in muddy deposits. Both branches have different channel-fill characteristics. Our findings provide strong evidence for intermittent behavior of overflow controlled by tectonic processes and regional climatic change. These fluctuations in paleo-MOW intermittently influenced global ocean circulation.
Genetic associations of myopia severities and endophenotypes in children
Authors: Li Fen Fen , Lu Shi Yao , Tang Shu Min , Kam Ka Wai , Pancy O S Tam , Yip Wilson W K , Young Alvin L , Tham Clement C , Pang Chi Pui , Yam Jason C. , Chen Li Jia 
Published: August 2020

ObjectiveTo investigate the associations of multiple single-nucleotide polymorphisms (SNPs) with the severities and endophenotypes of myopia in children.MethodsA total of 3300 children aged 5–10 years were recruited: 137 moderate and high myopia (SE≤−3.0D), 670 mild myopia (−3.0D<SE≤−0.5D) and 2493 controls (SE>−0.5D). 13 SNPs in 13 genes/loci were selected for genotyping in all subjects using TaqMan assays. Associations between each SNP with myopia severities and ocular traits (spherical equivalent (SE), axial length (AL) and corneal radius (CR)) were analysed.ResultsWhen compared with controls, SNPs ZC3H11B rs4373767 (OR=1.15, p=0.038), BICC1 rs7084402 (OR=1.18, p=0.005) and GJD2 rs524952 (OR=1.14, p=0.025) showed nominal associations with overall myopia. ZC3H11B rs4373767 and BICC1 rs7084402 showed stronger associations with moderate and high myopia (rs4373767: OR=1.42, p=0.018; rs7084402: OR=1.33, p=0.025), while GJD2 rs524952 had a stronger association with mild myopia (OR=1.14, p=0.025). GJD2 rs524952 also showed a difference between emmetropia and hyperopia (p=0.018). In quantitative trait locus analysis, ZC3H11B rs4373767, KCNQ5 rs7744813 and GJD2 rs524952 were correlated with both myopic SE (β=−0.09, p=0.03; β=−0.12, p=0.007; β=−0.13, p=0.0006, respectively) and AL (β=0.07, p=0.002; β=0.09, p=0.0008; β=0.07, p=0.0003, respectively). SNTB1 rs7839488 was correlated with both AL (β=0.07, p=0.005) and CR (β=0.02, p=0.006). Moreover, ZC3H11B rs4373767-T (β=0.006; p=0.018), KCNQ5 rs7744813-A (β=0.007; p=0.015) and GJD2 rs524952-T (β=0.009; p=0.0006) were correlated with AL-CR ratio.Conclusions and RelevanceZC3H11B and BICC1 are genetic risk factors for moderate and high myopia, while ZC3H11B, KCNQ5, SNTB1 and GJD2 confer risk to excessive AL in children.
Examining the relationship between poverty and length of stay: a repeated cross-sectional study of paediatric hospitalisations in Chile
Authors: Borrescio-Higa Florencia , Santistevan Dominiquo 
Published: August 2020

ObjectiveTo measure poverty-based disparities in inpatient length of stay for paediatric hospitalisations. In particular, this paper examines the relationship between municipality level poverty rates and length of stay, accounting for individual level characteristics.DesignWe use patient discharge data to conduct a repeated cross-sectional study of the totality of paediatric hospitalisations in 15 regions of Chile, in the years 2011, 2013, 2015 and 2017.SettingAll hospital discharges in 15 regions of Chile.Participants1 033 222 discharges for children under the age of 15, between 2011 and 2017.Outcome measuresLength of stay (LOS); LOS by type of insurance and type of hospital; hospitalisation rates; municipality-level average LOS.ResultsWe find that municipality level poverty rates are a significant predictor of LOS, even after controlling for individual and area level characteristics, including type of insurance. Children from municipalities in the poorest quintile have a LOS that is 14% shorter as compared with children from municipalities in the richest quintile. This relationship is stronger for publicly insured children: the decrease in LOS associated with the same poverty change is of 22%.ConclusionsThis paper shows that there is an association between municipality-level poverty rates and length of stay for paediatric hospitalisations in Chile. For the vast majority of the sample, and after controlling for individual level characteristics, an increase in the municipality level poverty rate is associated with a decrease in the length of stay. Further, there is a non-linearity in the relationship, where at the highest poverty rates, poverty and LOS are positively associated. These findings are robust after controlling for type of hospital (public vs private), type of insurance (public vs private), type of diagnosis, as well as year and region fixed effects.
The Vitamin D in Pregnancy Study: a prospective prebirth cohort in southern Australia
Authors: Hyde Natalie K , Brennan-Olsen Sharon L , Wark John D , Hosking Sarah M , Vuillermin Peter J , Williams Lana J , Pasco Julie A 
Published: August 2020

PurposeThe Vitamin D in Pregnancy Study is a long-term ongoing cohort study. It was conceived to explore relationships between maternal vitamin D status in pregnancy and offspring growth and development, and has since diversified to include a wide range of physical and mental health exposures and outcomes.ParticipantsRecruitment was from the University Hospital Geelong (Barwon Health) antenatal clinic, Geelong, Victoria, Australia, between 2002 and 2004. 475 women were initially recruited, which resulted in 400 eligible mother–child pairs at birth.Findings to dateThe cohort has been followed up twice in pregnancy, at birth, and 1 year, 6 years and 11 years post birth. The study has reported an association between vitamin D in pregnancy and musculoskeletal health and body composition in the children.Future plansSubject to funding, there will be a prospective young adult follow-up. This profile aims to foster both cross-national and international collaborations with both existing and future data collection.
Web-based MINDfulness and Skills-based distress reduction in cancer (MINDS): study protocol for a multicentre observational healthcare study
Authors: Bäuerle Alexander , Teufel Martin , Schug Caterina , Skoda Eva-Maria , Beckmann Mingo , Schäffeler Norbert , Junne Florian , Erim Yesim , Zipfel Stephan , Graf Johanna 
Published: August 2020

IntroductionAlthough a high percentage of patients with cancer experience severe psychological distress, few of them receive psycho-oncological care, largely due to barriers on the side of patients and healthcare providers that pose great challenges to delivering such care. In response, low-threshold, self-guided eHealth interventions can enable patients with cancer to deal independently and effectively with disease-related challenges and distress. Mindfulness and Skills-Based Distress Reduction in Oncology Training, nicknamed Make It Training, is one such innovative, self-guided eHealth intervention. In our study, we propose to assess different characteristics of such patients in order to define target populations for Make It Training, evaluate the intervention in terms of its usability, feasibility and sustainability and gather longitudinal data concerning the intervention’s efficacy.Methods and analysisSelf-guided and web-based Make It Training consists of eight 30 min modules involving the use of techniques of mindfulness therapy, cognitive–behavioural therapy and acceptance and commitment therapy to be completed in a 4-month period. In our observational study, adult patients with cancer who possess adequate German language skills and provide their informed consent will be recruited at Essen, Erlangen and Tübingen University Hospitals at outpatient oncological institutions and via online channels. Patients will undergo a baseline online assessment (T0), an assessment directly after completing the intervention (T1) and assessments 3 and 6 months later (T2 and T3, respectively). With the results of those assessments, we will perform descriptive analyses of their sociodemographic and medical data, compare means and conduct regression analyses.Ethics and disseminationThe Ethics Committees of the University Hospitals Essen, Erlangen and Tübingen have approved the study (19-8643-BO, 27_19 B, 293/2018BO1). Results will be published in peer-reviewed journals and conference presentations.Trial registration numberDRKS00017119.
Association between plasma exosome neurogranin and brain structure in patients with Alzheimer’s disease: a protocol study
Authors: He MengFei , Sun Li , Cao Wenhui , Yin Changhao , Sun Wenqiang , Liu Ping , Tan Lin , Xu Zheng , Zhao Weina 
Published: August 2020

IntroductionNeurogranin is known to be significantly elevated in patients with Alzheimer’s disease (AD) and may be an effective clinical predictor of cognitive decline and neurodegeneration. Amnestic mild cognitive impairment (aMCI) is an intermediate disease state between normal cognitive ageing and dementia, the latter of which can easily revert to AD. There remains significant uncertainty regarding the conversion of aMCI to AD, and therefore, elucidating such progression is paramount to the field of cognitive neuroscience. In this protocol study, we therefore aim to investigate the changes in plasma neurogranin in the early stage of AD and the mechanism thereof regarding the cognitive progression towards AD.Methods and analysisIn this study, patients with aMCI and AD patients (n=70 each) will be recruited at the memory clinic of the Department of Neurology of Hongqi Hospital affiliated with the Mudanjiang Medical University of China. Healthy older controls (n=70) will also be recruited from the community. All subjects will undergo neuroimaging and neuropsychological evaluations in addition to blood collection at the first year and the third year. We hope to identify a new biomarker of cognitive decline associated with AD and characterise its behaviour throughout the progression of aMCI to AD. This work will reveal novel targets for the therapeutic prevention, diagnosis and treatment of AD. The primary outcome measures will be (1) neuropsychological evaluation, including Mini-Mental State Examination, Montreal Cognitive Assessment, Clinical Dementia Rating scale, Shape Trail Test-A&B, Auditory Verbal Learning Test-HuaShan version; (2) microstructural alterations and hippocampal features from MRI scans; and (3) neurogranin levels in the neuronal-derived exosomes from peripheral blood samples.Ethics and disseminationThe ethics committee of the Hongqi Hospital affiliated with the Mudanjiang Medical University of China has approved this study protocol. The results will be published in peer-reviewed journals and presented at national or international scientific conferences.Trial registration numberChiCTR2000029055.
Impact of a novel community testing pathway for people with suspected COVID-19 in Wales: a cost-minimisation analysis
Authors: Currie Jonny , Adamson James , Bowden Bethan , Woolls Julie , Jones Rachel , Healy Brendan , Heyburn David , Shankar Ananda Giri , Howe Robin 
Published: August 2020

ObjectiveTo compare National Health Service (NHS) organisations’ testing pathways for patients with suspected COVID-19 in the community versus standard hospital testing practices.PerspectiveNHS commissioners and services.MethodsDuring the containment phase of the COVID-19 pandemic we developed a community model pathway for COVID-19 testing in Wales with testing teams undertaking swabbing for COVID-19 in individuals’ usual place of residence. We undertook a cost-minimisation analysis comparing the costs to the NHS in Wales of community testing for COVID-19 versus standard hospital testing practices and ambulance conveyancing. We analysed data from patients with suspected COVID-19 between January and February 2020 and applied assumptions of costs from national contractual and reference costs for ambulances, staffing and transportation with market costs at the time of publication.Results177 patients with suspected COVID-19 underwent community testing via local NHS organisations between January and February 2020 with a mean age of 46.1 (IQR 27.5–56.3). This was 92% of total patients who were tested for COVID-19 during this period. We estimate, compared with standard hospital testing practices, cash savings in improved productivity for the NHS of £24,539 during this time period, in addition to further non-monetised benefits for hospital and ambulance flow.ConclusionsCommunity testing for COVID-19 in Wales is now an established pathway and continues to bring benefits for patients, local healthcare organisations and the NHS. Further application of this model in other settings and to other infectious diseases may herald promising returns.