bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of financial constraints on the growth of family and nonfamily firms in Turkey
Authors: Ergün Bahadır , Doruk Ömer Tuğsal 
Published: July 2020

AbstractThis study examined whether family-owned firms have advantages for accessing external financial sources for growth. Especially in developing countries with imperfect markets, firms can face difficulties accessing external financing sources; however, family-owned firms might have some advantages in this regard over nonfamily firms. Unlike previous studies, this study considered that, in the Turkish context, nonfamily firms are financially constrained while family firms are not. To examine this hypothesis, we used the generalized method of moments (GMM) approach to analyze panel data from 2006 to 2017. The findings showed that financing constraints were a significant obstacle to growth for nonfamily-owned manufacturing firms while the effect was not present for family firms since they are controlled by large, well-established family groups. These results elucidate the relationship between corporate ownership and growth among Turkish firms, especially those with strong links to large family-owned corporations. The results also revealed that reputation and network may facilitate easier access to external financing sources, especially when considering the “Big Six” family ties of firms.
Potential of phytopathogenic fungal isolates as a biocontrol agent against some weeds
Authors: Mohammed Youssef M. M. , Badawy Mohamed E. I. 
Published: July 2020

AbstractBioherbicides afford satisfactory approach to overcome weed problem. Selection of new bioherbicides from phytopathogenic microbiota is essential for modern agricultural management, especially mycoherbicides. Thus, in the present investigation, 4 phytopathogenic fungi including Alternaria alternata YMM1, A. tenuissima YMM3, Chaetomium globosum YMM2, and Nigrospora oryzae YMM4 were isolated from infected leaves with chlorotic rings of Rumex dentatus and Sonchus oleraceus as common weeds in Egypt. These fungi were identified based on morphology and sequence analysis of ITS1-5.8SrDNA-ITS2 of rRNA genes. Mycoherbicidal metabolites were produced using submerged cultures in potato dextrose broth. Their bioherbicidal activities were evaluated using seed germination and leaf disk puncture assays. It was found that the most promising fungal strain against major tested weeds was N. oryzae YMM4. Thus, phytopathogenic microbiota are considered a great resource for the construction of a new bioherbicide for managing weeds.
Short-term follow-up of embolization of hip synovitis
Authors: Correa Mateus Picada , Puton Renan Camargo , Saleh Jaber Nashat , Noel Rafael Stevan , da Silva Luis Henrique Penteado , de Castro Daniela Medeiros , de Mello Bajesrki Julio Cesar 
Published: July 2020

Abstract
Background
Osteoarthritis (OA) is the most frequent joint disease, affecting 10% of men and 18% of women older than 60 years worldwide. Traditionally, treatment is based in pain management with joint replacement of end-stage disease. In this setting, transcatheter embolization has emerged as an alternative in reduction of pain in patients with OA.

Case presentation
A 77 years-old female presenting with two previous deep vein thrombosis and 10 years of hip pain. Magnetic resonance demonstrated a focal area of enhanced pericapsular signal near the superolateral margin of the acetabulum. Embolization of branches of the ascending branch of the lateral femoral circumflex artery was performed, with decrease of the pain and improvement in the image and her walking ability in a four-month follow-up.

Conclusion
This case report have shown that embolization of hip synovitis is feasible with early clinical success, in tune with the findings of genicular and shoulder embolization. Studies with more patients and long-term results are necessary to corroborate this finding.

Level of evidence
4
Acute suppurative thyroiditis with transient hyperthyroidism in thalassemia child: an uncommon association in a common disease—a rare case report
Authors: Sahoo Swaranjika , Biswal Basudev , Mohapatra Anuspandana , Sarangi Rachita 
Published: July 2020

Abstract
Background
Thyroid infection is rare in paediatric age group in anatomically normal thyroid gland. However, acute suppurative thyroiditis (AST) is common in high-risk cases like thyroglossal duct remnant and thyroglossal pyriform sinus fistula. This may be associated with variable thyroid dysfunctions. Though transient hyperthyroidism is reported in some cases, its association was not documented in thalassemia child.

Case presentation
We are reporting an 8-year-old male child with a history of fever, pain, and left neck swelling for 5 days. He was evaluated and empirically started intravenous antibiotics (ceftriaxone, cloxacillin, and amikacin) along with other supportive treatment for localized signs of thyroid infection. Ultrasonography of the neck revealed intercommunicating pockets of collections with internal echoes in the left thyroid lobe. CT neck was done and suggested that the left lobe of the thyroid gland was replaced by hypodense lesions of fluid attenuation without any congenital abnormality of the thyroid gland. His thyroid function tests were suggestive of biochemical hyperthyroidism. He was treated with intravenous antibiotics and ultrasonography-guided fine-needle aspiration of pus. His pus culture showed growth of methicillin resistant Staphylococcus aureus. He also had microcytic hypochromic anaemia which was evaluated and found to have thalassemia trait. His biochemical hyperthyroidism normalized after completion of 2 weeks of treatment and required no intervention.

Conclusion
Acute suppurative thyroiditis is an uncommon clinical condition in an anatomically normal thyroid gland which could be associated with thyroid dysfunction. Its association in a thalassemia child is also not documented in literature. Clinical evaluation and proper history taking and non-invasive thyroid imaging are the cornerstone for diagnosis. Antibiotics and pus drainage are the mainstay management. Associated biochemical hyperthyroidism is transient and resolves without any specific medication in asymptomatic cases.
Wound bed preparation: a case series using polyhexanide and betaine solution and gel—a UK perspective
Authors: Atkin Leanne , Stephenson John , Cooper Dawn M 
Published: July 2020

Objective: The burden of wound care within the NHS is estimated at a cost of £5.3 billion per year and is set to rise annually by 30%. This case series describes the results of using polyhexanide (PHMB) and betaine wound irrigation solution and gels (Prontosan, B.Braun Medical Ltd., UK) across the UK in hard-to-heal (also described as chronic) wounds up to 20 years' duration, with an observation period of greater than one month. Over half of the hard-to-heal wounds were healed and vast improvements to all other wounds were observed. Improvements to wound bed condition were reported as early as two days after commencing initial treatment, with decreases in malodour, exudate, slough and pain reported across the case series. In addition to wound bed improvements, a reduction in dressing change frequency of 55% was observed in hard-to-heal wounds under the new treatment regime.
Skin tear prevalence and incidence in the long-term care population: a prospective study
Authors: LeBlanc Kimberly , Woo Kevin Y , VanDenKerkhof Elizabeth , Woodbury M Gail 
Published: July 2020

Objective: The World Health Organization estimates that between 2015 and 2050 the proportion of the world's population over 60 years old will nearly double from 12% to 22%. An often overlooked byproduct of ageing is the skin changes associated with it, which heighten the risk of developing skin tears. Despite this presumed increased risk, the true impact of skin tears across age groups and care settings is poorly understood. The purpose of the present study was to establish the prevalence and incidence of skin tears in the Ontario long-term care population. Method: A prospective study design was used to explore the prevalence and incidence of skin tears. Individuals from four long-term care facilities in Ontario were followed over four weeks. The participants were examined for skin tears at the beginning of the study and at week four to determine whether skin tears had occurred and to record the skin tear type and location. Results: A total of 380 individuals, aged 65 years and over, took part. The study found a skin tear prevalence of 20.8% and an incidence of 18.9% within four weeks. These results provide much needed data on the burden of skin tears in the long-term care population. Conclusion: The present study is an important first step towards developing a prevention programme targeting individuals at risk for skin tears in long-term care.
Correlation between vitamin D levels and hard-to-heal wounds: a systematic review
Authors: Smith Karen , Hewlings Susan 
Published: July 2020

Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing. Method: PubMed and EBSCO databases were searched following PRISMA guidelines for primary research studies relating to pressure ulcers, diabetic ulcers or venous ulcers and vitamin D status. Results: A total of 10 studies, involving 2359 participants, met the inclusion criteria. There was a strong correlation between low levels of 25-hydroxyvitamin D and the presence of all three types of hard-to-heal wounds. Conclusion: Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is needed to understand the correlation between vitamin D and hard-to-heal wounds.
Use of a bacterial fluorescence imaging system to target wound debridement and accelerate healing: a pilot study
Authors: Cole Windy , Coe Stacey 
Published: July 2020

Objective: Optimal wound-bed preparation consists of regular debridement to remove devitalised tissues, reduce bacterial load, and to establish an environment that promotes healing. However, lack of diagnostic information at point-of-care limits effectiveness of debridement. Method: This observational case series investigated use of point-of-care fluorescence imaging to detect bacteria (loads >104CFU/g) and guide wound bed preparation. Lower extremity hard-to-heal wounds were imaged over a 12-week period for bacterial fluorescence and wound area. Results: A total of 11 wounds were included in the study. Bacterial fluorescence was present in 10 wounds and persisted, on average, for 3.7 weeks over the course of the study. The presence of red or cyan fluorescent signatures from bacteria correlated with an average increase in wound area of 6.5% per week, indicating stalled or delayed wound healing. Fluorescence imaging information assisted in determining the location and extent of wound debridement, and the selection of dressings and/or antimicrobials. Elimination of bacterial fluorescence signature with targeted debridement and other treatments correlated with an average reduction in wound area of 27.7% per week (p<0.05), indicative of a healing trajectory. Conclusion: These results demonstrate that use of fluorescence imaging as part of routine wound care enhances assessment and treatment selection, thus facilitating improved wound healing.
The impact of continuous electrical microcurrent on acute and hard-to-heal wounds: a systematic review
Authors: Ofstead Cori L , Buro Brandy L , Hopkins Krystina M , Eiland John E 
Published: July 2020

Background: Wound infections result in considerable morbidity, mortality and healthcare costs. Antibiotic resistance has complicated wound healing, and new, non-antibiotic-based treatment methods are being developed. Aims: To evaluate evidence on the safety, efficacy and real-world effectiveness of electroceutical devices (ECDs) that provide continuous electrical stimulation to wounds. Method: A systematic search was conducted to identify primary studies published between 2009 and 2019 that described therapeutic wound treatment using portable ECDs. Studies were included if the ECD delivered continuous electrical current directly to the wound area for the duration of treatment. Results: Of 171 citations identified in the search, 13 articles met the inclusion criteria and were analysed. Nine studies evaluated dressings embedded with zinc and silver particles that generated electricity electrochemically, and four evaluated electrode-based units with external batteries. ECDs were effective in healing complex, hard-to-heal wounds that had not responded to other treatments. Four studies showed that ECDs led to complete closure of wounds without complications, and in some cases healed wounds faster than standard of care (SOC). One study found that ECDs resulted in higher ratings by both patients and surgeons than SOC for the progression of wound healing and scar appearance. Additionally, three studies found ECD treatment was less expensive than SOC, due to patients requiring fewer dressing changes or nurse visits. Conclusion: ECDs appeared to be a safe, effective and cost-effective method for treating severe, complex and challenging wounds, including hard-to-heal wounds, surgical incisions and skin graft donor sites.
Actividad antimicrobiana de metabolitos secundarios de Aspergillus fumigatus sensu stricto sobre cepas clínicas de Staphylococcus aureus y Streptococcus pneumoniae
Authors: Sanchez-Perez Jorge A. , Béjar Castillo Vilma , Villanueva Cotrina Freddy , Guevara-Granados José M. 
Published: July 2020

Introducción. La resistencia a los antibióticos de bacterias Gram positivas es un grave problema de salud pública donde algunas medidas paliativas pueden encontrarse en los principios antimicrobianos de hongos filamentosos. Objetivo. Evaluar la actividad antimicrobiana de metabolitos secundarios de un aislamiento clínico de Aspergillus fumigatus sobre cepas clínicas de Staphylococcus aureus y Streptococcus pneumoniae. Métodos. La fermentación líquida de A. fumigatus se realizó en un caldo líquido sulfato, papa y dextrosa, utilizando acetato de etilo para la extracción de metabolitos. Mediante la metodología de disco difusión se evaluó la actividad antimicrobiana considerada como un halo mayor de 6 mm. Resultados. Se obtuvo una media de 24,02 ± 2,51 mm y 23,62 ± 4,68 mm de halo de inhibición sobre Staphylococcus aureus sensible y resistente oxacilina, respectivamente. Para Streptococcus pneumoniae sensibles y no sensibles a penicilina las medias fueron de 25,82 ± 4,05 mm y 26,5 ± 5,39 mm, respectivamente. Conclusiones. El extracto crudo de A. fumigatus posee metabolitos secundarios de naturaleza alcaloide y esteroles insaturados con actividad antimicrobiana.
Efecto de un programa de educación diabetológica en pacientes adultos de la consulta ambulatoria en un hospital nacional peruano
Authors: Paz-Ibarra José , Benites Regina 
Published: July 2020

Introducción. La diabetes tipo 2 es un problema de salud pública cuyo manejo es muy complejo, reconociéndose múltiples problemas y limitaciones para un adecuado control de la enfermedad. Objetivo. Determinar el efecto de un programa educativo añadido al tratamiento habitual, en el control de los pacientes con diabetes tipo 2 de la consulta especializada ambulatoria en un hospital nacional peruano. Métodos. Se realizó un estudio longitudinal analítico de tres meses de seguimiento, cincuenta pacientes consecutivos con diabetes tipo 2 no controlada que se atendían en la consulta ambulatoria del servicio de endocrinología aceptaron participar voluntariamente en las 4 sesiones grupales (5-8 participantes, 1sesión/semana). Se aseguró la disponibilidad de la medicación antidiabética, así como el mantenimiento de las dosis farmacológicas prescritas desde tres meses antes de la intervención y durante el periodo de seguimiento. Se determinaron los cambios en los niveles de HbA1c, glicemia en ayunas y perfil lipídico, antes y 3 meses después de la intervención. Resultados. Del total de pacientes que aceptaron participar, 41 completaron todas las sesiones y sus resultados fueron analizados. La cuarta parte eran varones. Luego de los tres meses de la intervención educativa, la HbA1c disminuyó -1,7%, la glicemia en ayunas -59mg/dL y el colesterol LDL -23mg/Dl, siendo los cambios significativos en los grupos de mayores de 45 años y con más de 5 años de diagnóstico. Conclusiones. El programa de educación diabetológica, añadido al manejo habitual, tuvo un efecto beneficioso temprano en el control de los pacientes con diabetes tipo 2 en un hospital nacional peruano.
Gestante con COVID 19 moderado y proceso de atención en el recién nacido
Authors: Ayala Ricardo , Miranda Loayda , Solís Tania , Valencia Norma , Cieza Liliana , Amado José 
Published: July 2020

La pandemia causada por COVID–19 (Coronavirus Disease 2019), viene produciendo un numero exponencial de infectados y muertes en diversos países del mundo, poniendo a prueba el sistema de salud de las mayores potencias mundiales y también en países como en Perú. Numerosos reportes ponen en evidencia la susceptibilidad de aquellos pacientes con comorbilidades y algún grado de compromiso inmunológico. Asimismo, en varios países del mundo ha generado preocupación la población de mujeres gestantes que debido a sus cambios fisiológicos e inmunología alterada sugieren un mayor impacto en el binomio madre - hijo.
Evolución de la pandemia COVID19 en las regiones andinas del Perú
Authors: Tello-Ayllón Carlos Alberto 
Published: July 2020

La pandemia COVID19 en el Perú, según el Comunicado N°79 del Ministerio de Salud de fecha 27 de abril del año 2020, reportó 28 699 casos y 782 fallecidos, siendo las regiones de Lima, Lambayeque, Loreto y Piura, las que presentaron una mayor dificultad de manejo de esta enfermedad. Sin embargo, esto no sucede en las regiones andinas del sur de nuestro país, en el cual las cifras señalan un porcentaje alto de personas asintomáticas o que han evolucionado de manera favorable a la enfermedad. El ejemplo más resaltante es Puno en donde, según los comunicados del Ministerio de Salud, desde su primer caso identificado el 7 de abril del 2020 ha mantenido un crecimiento exponencial en su tasa de contagios; sin embargo, todos sus casos fueron asintomáticos. En el Cusco, la Sala de Situación COVID-19 de la Dirección Regional de Salud reportó que existieron 195 casos confirmados y solo 3 personas hospitalizadas en sala COVID y 1 en UCI COVID, registrando 4 fallecidos, de los cuales 3 fueron de nacionalidad extranjera. En Ayacucho, se tiene referencia que todas las personas afectadas por COVID19 se encuentran estables o con una evolución favorable de esta enfermedad. Existe evidencia que en otras regiones como el Tibet en China y en Bolivia, que tienen similares características geográficas, también existió una evolución favorable de la pandemia.
Neumonía por COVID-19 y uso de tocilizumab
Authors: Cáceres-Bernaola Ursula , Becerra-Núñez Claudia , Mendívil-Tuchía de Tai Sabina , Ravelo-Hernández Jorge 
Published: July 2020

Se presenta el caso de un paciente varón de 44 años, personal de salud con hipertensión arterial, que tuvo contacto con pacientes con neumonía por COVID-19. Presentó compromiso pulmonar severo de rápida progresión clínico-radiológica, recibió tratamiento según la evidencia en el momento de su admisión y un antagonista del receptor de interleucina 6 (tocilizumab) como uso compasivo, obteniendo una respuesta clínica favorable.
Factores asociados a calidad de sueño en conductores informales de buses interprovinciales a gran altitud geográfica en Perú
Authors: Huamán Olarte Ramón Julio , Mujica Alban Elydia C. 
Published: July 2020

Objetivo. Determinar factores asociados a calidad de sueño (CS) en conductores informales de transporte interprovincial en la carretera central Lima-Huancayo durante el primer trimestre del 2018. Métodos. Estudio transversal. Se obtuvo datos sociodemográficos y ocupacionales. Se aplicó el Índice de Calidad de Sueño de Pittsburgh (ICSP). Se obtuvo la prevalencia y factores asociados a CS. Resultados. Participaron 162 conductores. La edad promedio fue 42 ± 10,2 años, 55,6% tenía grado de instrucción técnico, 42% eran casados, 55,6% presentaba dos a tres hijos, 54,9% tenía sobrepeso y 32,1% obesidad. La media del tiempo de experiencia laboral fue 17 ± 6,8 años. El ICSP promedio fue 8,1 ± 3. El 89,6 % presentaba alta frecuencia de CS alterada con grados variables. La edad (p = 0,03) fue el factor asociado a CS alterada. Conclusión. Existe una alta prevalencia de CS alterada en conductores informales. La edad constituyó el principal factor asociado a CS.
Densidad de la masa ósea y marcadores bioquímicos del metabolismo óseo: estudio transversal en adultos residentes de Lima Metropolitana, Perú
Authors: Garmendia-Lorena Fausto , Pando-Álvarez Rosa , Ruiz-Franco Oscar , Salas-Pérez Marcia , Chuquihuara-Rodríguez Ángela , Hidalgo-García Arquímedes , Hernández-Alegre Martín , Ronceros-Medrano Gerardo , Larrabure-Torrealva Gloria , Fuentes-Rivera José , Yactayo-Silva Diana , Orellana-Cortez Alex , Pichardo-Rodríguez Rafael 
Published: July 2020

Objetivos. Determinar y correlacionar la densidad mineral ósea (DMO) y los marcadores bioquímicos del metabolismo óseo de adultos de 30 a 40 años de Lima, Perú, en el año 2018. Métodos. Estudio descriptivo, transversal, realizado a 84 mujeres y 53 varones, de 30 a 40 años de edad, residentes en Lima, Perú, sin manifestaciones ni tratamiento de enfermedades metabólicas óseas primarias ni secundarias. Se registró información del estado actual, antecedentes personales fisiológicos, patológicos, familiares y examen clínico. Se midió la DMO por absorciometría dual de rayos X en columna, cadera y antebrazo; en sangre, parathormona, osteocalcina, 25-hidroxi-vitamina-D, hormona luteinizante, estradiol en las mujeres, testosterona en los varones, calcio sérico, fósforo sérico, fosfatasa alcalina, proteínas totales y fracciones, creatinina; en orina N-telopéptido de enlaces de colágeno tipo I, calcio y fósforo, por métodos convencionales. Resultados. La DMO se efectuó a 62 mujeres y 40 varones; 2 mujeres y 1 varón tuvieron osteoporosis, y 3 mujeres y 2 varones osteopenia, retirados para la evaluación estadística; 58 mujeres y 35 varones tuvieron una DMO normal. Los varones tuvieron mayor DMO y concentraciones mayores de calcio, fosfatasa alcalina y creatinina; 14 mujeres y 2 varones tuvieron cifras bajas de 25-OH-vitaminaD. Hubo correlación positiva entre DMO y el IMC. Conclusiones. La DMO normal de personas de 30 a 40 años de Lima fue lineal y hubo una relación positiva con el IMC; hubo osteoporosis en 2 mujeres y 1 varón, osteopenia en 3 mujeres y 2 varones, cifras bajas de 25-hidroxi-vitamina-D en 16 personas.