bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human versus artificial intelligence: evaluating ChatGPT’s performance in conducting published systematic reviews with meta-analysis in chronic pain research
Authors: Purewal Anam , Fautsch Kalli , Klasova Johana , Hussain Nasir , D'Souza Ryan S 
Published: February 2025

IntroductionArtificial intelligence (AI), particularly large-language models like Chat Generative Pre-Trained Transformer (ChatGPT), has demonstrated potential in streamlining research methodologies. Systematic reviews and meta-analyses, often considered the pinnacle of evidence-based medicine, are inherently time-intensive and demand meticulous planning, rigorous data extraction, thorough analysis, and careful synthesis. Despite promising applications of AI, its utility in conducting systematic reviews with meta-analysis remains unclear. This study evaluated ChatGPT’s accuracy in conducting key tasks of a systematic review with meta-analysis.MethodsThis validation study used data from a published meta-analysis on emotional functioning after spinal cord stimulation. ChatGPT-4o performed title/abstract screening, full-text study selection, and data pooling for this systematic review with meta-analysis. Comparisons were made against human-executed steps, which were considered the gold standard. Outcomes of interest included accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for screening and full-text review tasks. We also assessed for discrepancies in pooled effect estimates and forest plot generation.ResultsFor title and abstract screening, ChatGPT achieved an accuracy of 70.4%, sensitivity of 54.9%, and specificity of 80.1%. In the full-text screening phase, accuracy was 68.4%, sensitivity 75.6%, and specificity 66.8%. ChatGPT successfully pooled data for five forest plots, achieving 100% accuracy in calculating pooled mean differences, 95% CIs, and heterogeneity estimates (I2score and tau-squared values) for most outcomes, with minor discrepancies in tau-squared values (range 0.01–0.05). Forest plots showed no significant discrepancies.ConclusionChatGPT demonstrates modest to moderate accuracy in screening and study selection tasks, but performs well in data pooling and meta-analytic calculations. These findings underscore the potential of AI to augment systematic review methodologies, while also emphasizing the need for human oversight to ensure accuracy and integrity in research workflows.
Self-expanding foam injected into the peritoneal space improves survival in a model of complex pelvic fracture and retroperitoneal exsanguination
Authors: Pham Quynh P , Hwabejire John O , Elsharkawy Ahmed E , Eid Ahmed I , Duggan Michael J , Gelsinger Shawn , Fornaciari Michael , Sharma Upma , King David R 
Published: February 2025

BackgroundMortality for patients with pelvic fracture with hemorrhagic shock ranges from 21% to 57%. ResQFoam administered intra-abdominally has previously been shown to provide a survival benefit in large-animal models of abdominal exsanguination. It also significantly decreased mortality in models of retroperitoneal hemorrhage with complex pelvic fracture when deployed in the preperitoneal space. We hypothesized that percutaneously administered ResQFoam into the abdominal cavity could decrease mortality in exsanguinating pelvic hemorrhage.MethodsUsing non-coagulopathic Yorkshire swine, the injury model consisted of a unilateral, closed-cavity retroperitoneal vascular hemorrhage (with intraperitoneal communication) combined with a complex pelvic fracture. After the injury, animals received fluid resuscitation alone (control, n=14), fluid resuscitation with ResQFoam deployed in the preperitoneal pelvic space (n=10), or fluid resuscitation with ResQFoam deployed intra-abdominally (n=10). Hemodynamic monitoring was continued for 3 hours or until death.ResultsIntra-abdominal and preperitoneal use of ResQFoam provided a similar significant survival benefit compared with controls. The median survival times for the intra-abdominal and preperitoneal ResQFoam groups were 87 and 124 min, respectively, compared with 17 min for the control group (p=0.008 and 0.002, respectively). The survival rate at 3 hours was 40% for both ResQFoam groups compared with 0% in controls (p=0.020). There was no significant difference in the median survival time or overall survival curves between the two ResQFoam groups (p=0.734 and p=0.975, respectively). Both ResQFoam groups stabilized mean arterial pressure and significantly reduced hemorrhage rate. The average hemorrhage rate in control animals was 4.9±4.6 g/kg/min compared with 0.6±0.6 g/kg/min and 0.5±0.5 g/kg/min in the intra-abdominal (p=0.008) and preperitoneal (p=0.002) ResQFoam groups, respectively.ConclusionsSimilar survival benefit and hemorrhage control were achieved with ResQFoam in the treatment of exsanguinating pelvic hemorrhage with complex pelvic fracture whether it was administered preperitoneally or intra-abdominally. Thus, ResQFoam can be administered intra-abdominally to treat either abdominal or pelvic hemorrhage.Level of evidenceNot applicable (animal study).
AUTOMATED GENERATION OF TEST TRAJECTORIES FOR EMBEDDED FLIGHT CONTROL SYSTEMS
Authors: CUKIC BOJAN , TAYLOR BRIAN J. , SINGH HARSHINDER 
Published: July 2002

Automated generation of test cases is a prerequisite for fast testing. Whereas the research in automated test data generation addressed the creation of individual test points, test trajectory generation has attracted limited attention. In simple terms, a test trajectory is defined as a series of data points, with each (possibly multidimensional) point relying upon the value(s) of previous point(s). Many embedded systems use data trajectories as inputs, including closed-loop process controllers, robotic manipulators, nuclear monitoring systems, and flight control systems. For these systems, testers can either handcraft test trajectories, use input trajectories from older versions of the system or, perhaps, collect test data in a high fidelity system simulator. While these are valid approaches, they are expensive and time-consuming, especially if the assessment goals require many tests. We developed a framework for expanding a small, conventionally developed set of test trajectories into a large set suitable, for example, for system safety assurance. Statistical regression is the core of this framework. The regression analysis builds a relationship between controllable independent variables and closely correlated dependent variables, which represent test trajectories. By perturbing the independent variables, new test trajectories are generated automatically. Our approach has been applied in the safety assessment of a fault tolerant flight control system. Linear regression, multiple linear regression, and autoregressive techniques are compared. The performance metrics include the speed of test generation and the percentage of "acceptable" trajectories, measured by the domain specific reasonableness checks.
sTeam
Authors: Hampel Thorsten , Keil-Slawik Reinhard 
Published: July 2002

Learning is a socially embedded design process. But most of todays hypermedia systems fail to properly support the design-related and the social aspects of learning. Authoring and Web-publishing systems aim to support the authors design processes. Consequently, the activities of learners are confined to selecting and reading. Based on some fundamental reflections on the role of technology in learning processes, we conclude that top priority must be given to the construction of infrastructures that support cooperative learning processes if we are to properly harness the technologys potential.
We present a learner-centered, wholly Web-based approach for structuring information in teams (sTeam). In sTeam the key concept is virtual space. It draws cooperation and communication together, while at the same time embodying the common external memory of a (virtual) learning group. Hence, the focus is not on interactive systems for individual access of knowledge bases, but on the cooperative management and structuring of distributed knowledge bases.
Genetic Diversity in Hominoid Primates
Authors: Ruvolo M. 
Published: July 2002

Humans are only one of the species produced by the hominoid evolutionary radiation. Common and pygmy chimpanzees (our closest relatives), gorillas, orangutans, and the lesser apes also belong to this group. In humans, patterns of genetic variation are becoming increasingly better characterized by modern molecular methods. Understanding human variation in an evolutionary context, however, requires comparison of human patterns with those of other hominoids, to reveal features shared among hominoids and those unique to humans. Genetic variation among chimpanzees, gorillas, and orangutans is beginning to be characterized, so that comparisons are now possible. From genetic data, several different kinds of information can be reconstructed, including the evolutionary relatedness of subspecies and populations, time estimates for evolutionary divergences, past population dynamics, extent of gene flow over geographical landscapes, and group social structure. Knowledge of hominoid genetic variation is also relevant to applied fields such as primate conservation and medicine.
MINIMALLY INVASIVE SURGERY
Authors: Vierra, M.D Mark 
Published: July 2002

▪ Abstract  With the widespread introduction of laparoscopic cholecystectomy in late 1989, the practice and expectations of general surgery were changed forever. The techniques of laparoscopy were not new—they had been adopted by gynecologists and orthopedic surgeons at least a decade before—but it was laparoscopic cholecystectomy that captured the attention of the surgical profession and the public and spawned the tremendous growth in what has come to be called minimally invasive surgery. Although this surgery has tremendous appeal, offering quicker recovery, less pain, and possibly greater safety, it presents new challenges in the areas of training, credentialing, and quality assessment and raises serious questions about the real benefits of new technology at a time when the political and economic sensitivity of these issues is greater than ever. In this chapter I limit myself to a discussion of laparoscopy in general surgery, with a focus on what we have learned from laparoscopic cholecystectomy and on what this knowledge suggests for the future of other laparoscopic general surgical procedures.
SULFUR TUFT AND TURKEY TAIL: Biosynthesis and Biodegradation of Organohalogens by Basidiomycetes
Authors: de Jong Ed , Field Jim A. 
Published: July 2002

▪ Abstract  Chlorinated aliphatic and aromatic compounds are generally considered to be undesirable xenobiotic pollutants. However, the higher fungi, Basidiomycetes, have a widespread capacity for organohalogen biosynthesis. Adsorbable organic halogens (AOX) and/or low-molecular-weight halogenated compounds are produced by Basidiomycetes of 68 genera from 20 different families. Most of the 81 halogenated metabolites identified from Basidiomycetes to date are chlorinated, although brominated and iodated metabolites have also been described. Two broad categories of Basidiomycete organohalogen metabolites are the halogenated aromatic compounds and the haloaliphatic compounds. Some of these organohalogen metabolites have demonstrable physiological roles as antibiotics and as metabolites involved in lignin degradation. Basidiomycetes produce large amounts of low-molecular-weight organohalogens or adsorbable organic halogens (AOX) when grown on lignocellulosic substrates. In our view, Basidiomycetes, as decomposers of forest litter, are a major source of natural organohalogens in terrestrial environments.Basidiomycetes are also potent degraders of a wide range of chlorinated pollutants, such as bleachery effluent from kraft mills and pentachlorophenol, polychlorinated dioxins, and polychlorinated biphenyls. The extracellular, lignin-degrading enzymes of the Basidiomycetes are involved in the oxidative degradation of chlorophenols and dioxin and can cause reductive dechlorination of halomethanes.There is no clear-cut separation between “polluters” and “clean-uppers” within the Basidiomycetes. Several genera, e.g. Bjerkandera, Hericium, Phlebia, and Trametes, produce significant amounts of chlorinated compounds but are also highly effective in metabolizing or biotransforming chlorinated pollutants.
MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM
Authors: Meyer Urs A. , Zanger Ulrich M. 
Published: July 2002

▪ Abstract  One of the major causes of interindividual variation of drug effects is genetic variation of drug metabolism. Genetic polymorphisms of drug-metabolizing enzymes give rise to distinct subgroups in the population that differ in their ability to perform certain drug biotransformation reactions. Polymorphisms are generated by mutations in the genes for these enzymes, which cause decreased, increased, or absent enzyme expression or activity by multiple molecular mechanisms. Moreover, the variant alleles exist in the population at relatively high frequency. Genetic polymorphisms have been described for most drug metabolizing enzymes. The molecular mechanisms of three polymorphisms are reviewed here. The acetylation polymorphism concerns the metabolism of a variety of arylamine and hydrazine drugs, as well as carcinogens by the cytosolic N-acetyltransferase NAT2. Seven mutations of the NAT2 gene that occur singly or in combination define numerous alleles associated with decreased function. The debrisoquine-sparteine polymorphism of drug oxidation affects the metabolism of more than 40 drugs. The poor metabolizer phenotype is caused by several “loss of function” alleles of the cytochrome P450 CYP2D6 gene. On the other hand, “ultrarapid” metabolizers are caused by duplication or amplification of an active CYP2D6 gene. Intermediate metabolizers are often heterozygotes or carry alleles with mutations that decrease enzyme activity only moderately. The mephenytoin polymorphism affects the metabolism of mephenytoin and several other drugs. Two mutant alleles of CYP2C19 have so far been identified to cause this polymorphism. These polymorphisms show recessive transmission of the poor or slow metabolizer phenotype, i.e. two mutant alleles define the genotype in these individuals. Simple DNA tests based on the primary mutations have been developed to predict the phenotype. Analysis of allele frequencies in different populations revealed major differences, thereby tracing the molecular history and evolution of these polymorphisms.
Anthropometric Indices and Metabolic Dysfunction–Associated Fatty Liver Disease in Males and Females Living With Severe Obesity
Authors: Lajeunesse-Trempe Fannie , Dugas Selena , Maltais-Payette Ina , Tremblay Ève-Julie , Piché Marie-Eve , K. Dimitriadis Georgios , Lafortune Annie , Marceau Simon , Biertho Laurent , Tchernof André 
Published: February 2025

Introduction: Metabolic dysfunction–associated fatty liver disease (MAFLD) is highly prevalent among people living with severe obesity (body mass index [BMI] ≥ 35 kg/m2). However, it remains unknown how sex and adipose tissue distribution are related to MAFLD onset and progression into metabolic dysfunction–associated steatohepatitis (MASH) or advanced stages of fibrosis.Methodology: We retrospectively studied patients with severe obesity who were eligible for bariatric surgery. Demographic characteristics, biomarkers, and cardiometabolic comorbidities were reported. Anthropometric indices such as BMI, waist circumference (WC), waist‐to‐hip ratio (WHR), waist‐to‐height ratio (WHtR), neck circumference (NC), lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index (BAI), abdominal volume index (AVI), and body roundness index (BRI) were measured or calculated. MAFLD, MASH, and stages of fibrosis (F1‐F4) were established from perioperative liver biopsies. Standardized univariate and multivariate logistic regression analyses were used to examine the association between demographic variables, anthropometric indices, cardiometabolic conditions, and the risk of MASH or severe fibrosis (F2‐F4).Results: A total of 2091 participants with severe obesity were included in the analyses; BMI 47.9 ± 7.3 kg/m2, age 46.2 ± 11.2 years, and 68.4% females. Overall, MAFLD prevalence was 79.5%, with 44.5% having MASH and 24.4% having severe fibrosis (Stage 2 or higher). No anthropometric indices of adiposity were associated with MASH or fibrosis severity. In this population, female sex was a risk factor for severe fibrosis (OR: 1.27, 95% CI 1.01–1.59, p < 0.05).Conclusions: MAFLD and MASH are highly prevalent in individuals living with severe obesity, but no anthropometric indices or laboratory tests are good predictors of MAFLD or MASH in this population. When MAFLD is diagnosed, our results suggest that females with severe obesity might be at higher risk of advanced stages of fibrosis.
Public Policy, Private Preferences, and the Japanese Trade Pattern
Authors: Noland Marcus 
Published: July 2002

Abstract
As nontariff forms of trade protection proliferate it has become more difficult to analyze the impact of trade policy on trade flows. In a number of well-known papers researchers have attempted to infer the impact of trade policy indirectly by ascribing to trade policy the differences between actual and predicted trade flows. Much of the work has been applied to analysis of Japanese trade policy, and the conclusions of these studies have differed widely. Some previous research has also ascribed a role to the keiretsu, or networks of affiliated firms, in explaining Japan's apparently distinctive trade performance.
This paper presents a model that integrates data on factor endowments, observable protection in traditional and nontraditional forms, and the keiretsu. It extends existing research in two principal ways. First, alternative cross-national models of comparative advantage are nested to permit the identification of critical modeling assumptions underlying the divergent conclusions of the previous studies. Second, the results of the indirect method are externally validated by confronting these inferences with data on trade policy and the keiretsu. The results indicate that trade policy and the keiretsu have an important impact on Japanese trade performance.
Functional Anatomical Correlates of Controlled and Automatic Processing
Authors: Jansma Johan Martijn , Ramsey Nick F. , Slagter Heleen A. , Kahn Rene S. 
Published: July 2002

Abstract
Behavioral studies have shown that consistent practice of a cognitive task can increase the speed of performance and reduce variability of responses and error rate, reflecting a shift from controlled to automatic processing. This study examines how the shift from controlled to automatic processing changes brain activity. A verbal Sternberg task was used with continuously changing targets (novel task, NT) and with constant, practiced targets (practiced task, PT). NT and PT were presented in a blocked design and contrasted to a choice reaction time (RT) control task (CT) to isolate working memory (WM)-related activity. The three-dimensional (3-D) PRESTO functional magnetic resonance imaging (fMRI) sequence was used to measure hemodynamic responses. Behavioral data revealed that task processing became automated after practice, as responses were faster, less variable, and more accurate. This was accompanied specifically by a decrease in activation in regions related to WM (bilateral but predominantly left dorsolateral prefrontal cortex (DLPFC), right superior frontal cortex (SFC), and right frontopolar area) and the supplementary motor area. Results showed no evidence for a shift of foci of activity within or across regions of the brain. The findings have theoretical implications for understanding the functional anatomical substrates of automatic and controlled processing, indicating that these types of information processing have the same functional anatomical substrate, but differ in efficiency. In addition, there are practical implications for interpreting activity as a measure for task performance, such as in patient studies. Whereas reduced activity can reflect poor performance if a task is not sensitive to practice effects, it can reflect good performance if a task is sensitive to practice effects.
Striatal Contribution to Cognition: Working Memory and Executive Function in Parkinson's Disease before and after Unilateral Posteroventral Pallidotomy
Authors: Jahanshahi M. , Rowe J. , Saleem T. , Brown R. G. , Limousin-Dowsey P. , Rothwell J. C. , Thomas D. G. T. , Quinn N. P. 
Published: July 2002

Abstract
The basal ganglia are intimately connected to the frontal cortex via five fronto-striatal circuits. While the role of the frontal cortex in cognition has been extensively studied, the contribution of the basal ganglia to cognition has remained less clear. In Parkinson's disease, posteroventral pallidotomy (PVP) involves surgical lesioning of the internal section of the globus pallidus (GPi, the final output pathway from the basal ganglia) to relieve the motor symptoms of the disorder. PVP in Parkinson's disease provides a unique opportunity to investigate the impact of disruption of striatal outflow to the frontal cortex on cognition. We assessed executive function and working memory after withdrawal of medication in 13 patients with Parkinson's disease before and 3 months after unilateral PVP compared to 12 age-and IQ-matched normals assessed twice with an interval of 3 months. The tests used were: Wisconsin Card Sorting (WCST), Self-Ordered Random Number Sequences, Missing Digit Test, Paced Visual Serial Addition Test (PVSAT), and Visual Conditional Associative Learning Test (VCALT). After PVP, the patients performed significantly better on the Self-Ordered Random Number Sequences and the WCST, an improvement that was also observed in the normals across the two assessment and is therefore likely to reflect practice effects. Relative to the normals, the patients showed significant differential change following PVP on the Missing Digit Test and PVSAT, on which they performed worse after compared to before surgery, while the controls performed better on the second assessment. For the patients, performance on the VCALT also indicated deterioration after PVP, but the changes approached significance. The side of PVP had no effect on the results. The pattern of change observed 3 months after PVP was maintained at 15-month follow-up. The results suggest that striatal outflow to the frontal cortex may be essential for those aspects of executive function that showed deterioration after PVP. &
The Mixing Triangle: Correlation and Graphical Decision Support for LCA‐based Comparisons
Authors: Hofstetter Patrick , Braunschweig Arthur , Mettier Thomas , Müller‐Wenk Ruedi , Tietje Olaf 
Published: July 2002

SummaryRecent developments within life‐cycle impact assessment (LCIA) allow direct modeling of changes to predefined safeguard subjects that represent the environment to be protected. These changes are often expressed in a few damage indicators and calculated for each product alternative to be compared. This article analyzes the correlation among damage indicators within one specific LCIA methodology, assesses the implications of such correlation for the use of weighting methods, and proposes a method for graphically displaying choices with respect to weighting.