bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data centers as the backbone of smart cities: principal considerations for the study of facility costs and benefits
Authors: Lam Patrick T.I. , Lai Daniel , Leung Chi-Kin , Yang Wenjing 
Published: October 2020

Purpose
As smart cities flourish amidst rapid urbanization and information and communication technology development, the demand for building more and more data centers is rising. This paper aims to examine the principal issues and considerations of data center facilities from the cost and benefit dimensions, with an aim to illustrate the approaches for maximizing the net benefits and remain “green.”

Design/methodology/approach
A comprehensive literature review informs the costs and benefits of data center facilities, and through a case study of a developer in Hong Kong, the significance of real estate costs is demonstrated.

Findings
Major corporations, establishments and governments need data centers as a mission critical facility to enable countless electronic transactions to take place any minute of the day. Their functional importance ranges from health, transport, payment, etc., all the way to entertainment activities. Some enterprises own them, whilst others use data center services on a co-location basis, in which case data centers are regarded as an investment asset. Real estate costs affect their success to a great extent, as in the case of a metropolitan where land cost forms a substantial part of the overall development cost for data centers.

Research limitations/implications
As the financial information of data center projects are highly sensitive due to the competitive status of the industry, a full set of numerical data is not available. Instead, the principles for a typical framework are established.

Originality/value
Data centers are very energy intensive, and their construction is usually fast tracked costing much to build, not to mention the high-value equipment contents housed therein. Their site locations need careful selection due to stability and security concerns. As an essential business continuity tool, the return on investment is a complex consideration, but certainly the potential loss caused by any disruption would be a huge amount. The life cycle cost and benefit considerations are revealed for this type of mission-critical facilities. Externalities are expounded, with emphasis on sustainable issues. The impact of land shortage for data center development is also demonstrated through the case of Hong Kong.
Optimal design of the slip–texture on a journal-bearing surface
Authors: Jin Jian , Chen Xiaochao , Fu Yiyang , Chang Yinhui 
Published: October 2020

Purpose
This work aims to explore the combined effects of boundary slip and texturing on hydrodynamic journal bearings and identifies optimized slip and texture patterns to improve the performance of journal bearings.

Design/methodology/approach
The quadratic programming technique is used to study the influence of boundary slip on the lubrication performance of a two-dimensional journal bearing. A numerical model is used to analyze the effect of the cylindrical texture shape on the characteristics of journal bearings. It is concluded that the combination of slip and texture can be an effective approach to improve the performance of hydrodynamic journal bearings.

Findings
The results show that there is an interfacial shear stress (perfect slip surface) and that the role of the slip regime is to reduce friction. Numerical analyses indicate that the location and size of the slip and texture zone have a large effect on journal bearings. A comparison of the distribution forms of various texture–slip combinations indicates that the full texture–slip combination can prominently reduce the load-carrying capacity and that the “forward-slip backward-texture” configuration can considerably improve the performance of journal bearings.

Originality/value
The combined effects of boundary slip and texture on hydrodynamic journal bearings are meticulously examined. The patterns of the slip and texture are optimized, which can substantially improve the journal bearing performance.
Outcomes of a nutrition service provided by dietitians at a major multi‐cultural competition event: An observational study
Authors: Pelly Fiona E. , Wright Hattie H. 
Published: October 2020

AbstractAimThe nutrition service available for athletes competing at major events varies significantly and is dependent on advocacy for dietetic inclusion. The aim of this study was to describe the outcomes of a nutrition service designed and led by dietitians at a major international competition: the 2017 Taipei Universiade.MethodsAthletes (university students aged 17‐25 years) and officials that used the service were invited to participate. Occasions of service were recorded using standard pro formas and dietary analysis of consultations was conducted using Foodworks.ResultsThe scope of the service included 242 enquiries, 884 weight checks, 25 skinfold measures and 37 consultations. A significantly higher proportion of females asked about food allergy/intolerance (26.2% vs 12.5%, P = .039) than males. Most athletes who sought a nutrition consultation had not received previous nutrition support (86.5%) and wanted performance‐related meal plans and advice (81.1%). On average, their diets were adequate in micronutrients with the exception of calcium, and low in serves of vegetables and dairy products. The majority of athletes (72.9%) seeking a consultation reported that they did not follow a specific diet for their sport. Sports supplements, performance enhancers and vitamin‐mineral supplements use was 45.9% (n = 17), 13.5% (n = 5) and 13.5% (n = 5), respectively. Most athletes were of a high international calibre, however, reported low confidence in their nutrition knowledge and did not consistently apply knowledge to practice.ConclusionThis demonstrates a need for nutrition services by dietitians at this and similar events to improve the dietary intake of young adult athletes.
Vole activity surveys predict damage to cover‐cropped soybean plants
Authors: Prieur Abby‐Gayle A. , Swihart Robert K. 
Published: October 2020

AbstractAcross the Midwestern United States, farmers have increasingly used winter cover crops in corn–soybean rotations to improve soil health. Although this practice has many benefits, it also can provide habitat for potential pest species, such as voles (Microtus pennsylvanicus and M. ochrogaster). Voles have been reported by farmers to damage soybean plants in fields which had recently been cover cropped, but little has been done to quantify levels of damage related to their abundance. We evaluated the relationship between vole sign and soybean plant damage to help farmers manage this unintended consequence of using cover crops. We counted the frequency of vole sign along transects in cover‐cropped fields. In addition to vole sign, we considered influence of cover‐crop density, distance to field edge, and presence of artificial raptor perches when fitting negative binomial generalised linear mixed models to predict amount of soybean plant damage. An additive model including all explanatory variables and factors best explained variation in vole damage. Number of burrow entrances, presence of raptor perches, and cover‐crop density were positively associated with soybean plant damage. Burrow entrances were most strongly associated with damage. Farmers can use frequency of burrow entrances to predict relative amounts of damage likely to be incurred; conditions in a field should be considered when deciding to manage for reduced vole populations before planting soybeans.
Reducing preventable harm to residents in aged care: A systems approach
Authors: Hibbert Peter D. , Clay‐Williams Robyn , Westbrook Johanna , Reed Richard L. , Georgiou Andrew , Wiles Louise K. , Molloy Charlotte J. , Braithwaite Jeffrey 
Published: October 2020

AbstractResidents in Australian aged care facilities can suffer serious preventable harm from incidents (‘adverse events’ (AEs)). An inadequate response to AEs by aged care facilities can compound distress to residents and their families/carers. Facilities have an obligation to respond to and investigate AEs involving residents, learn from them, and take action to reduce the chance of them reoccurring . Residential aged care facilities have a duty to create a culture where staff, residents and families/carers feel comfortable reporting AEs or complaints; there is adequate time and resources to manage AEs and complaints; and feedback is provided to staff, residents and their families/carers on the results of investigations into AEs/complaints. The Aged Care Quality and Safety Commission's role should encompass additional governance functions such as sharing results and lessons learnt from AEs, complaints and investigations across Australia, assuring the quality of investigations conducted by facilities, and undertaking national system‐wide investigations.
Parents' perspectives, information needs and healthcare preferences when consulting for their children with bronchiolitis: A qualitative study
Authors: Piché‐Renaud Pierre‐Philippe , Thibault Louis‐Philippe , Essouri Sandrine , Chainey Annik , Thériault Corinne , Bernier Gabrielle , Gaucher Nathalie 
Published: October 2020

AbstractAimBronchiolitis is the leading cause of hospitalisation in infants, but parental experiences have not been well described. This study explored parents’ experiences and asked them how they wanted to receive information.MethodsA qualitative study was conducted in a tertiary paediatric hospital in Québec, Canada. It consisted of semi‐structured interviews with 15 parents of 13 children with bronchiolitis. The interview guide was constructed by a multidisciplinary team that included a parent. The interviews, which were transcribed verbatim, were conducted until no new themes emerged.ResultsWe interviewed eight mothers, three fathers and two couples for 22‐70 minutes: six were carried out in person during the bronchiolitis episode, and seven were phone interviews after a median interval time of 107 days. Parents were very worried about their child’s health and their lack of knowledge about bronchiolitis contributed to their anxiety. They found education resources informative, but expressed a strong need for support and reassurance from healthcare teams. The two groups provided similar feedback, regardless of when they were interviewed or whether their child was admitted.ConclusionAlthough bronchiolitis is common in infancy, parental knowledge was low. Standardised educational tools were useful, but insufficient to meet all their needs.
Application of the Health Action Process Approach to Social Distancing Behavior During COVID‐19
Authors: Hamilton Kyra , Smith Stephanie R. , Keech Jacob J. , Moyers Susette A. , Hagger Martin S. 
Published: October 2020

BackgroundThis study examined the social cognition determinants of social distancing behavior during the COVID‐19 pandemic in samples from Australia and the US guided by the health action process approach (HAPA).MethodsParticipants (Australia: N = 495, 50.1% women; US: N = 701, 48.9% women) completed HAPA social cognition constructs at an initial time‐point (T1), and one week later (T2) self‐reported their social distancing behavior.ResultsSingle‐indicator structural equation models that excluded and included past behavior exhibited adequate fit with the data. Intention and action control were significant predictors of social distancing behavior in both samples, and intention predicted action and coping planning in the US sample. Self‐efficacy and action control were significant predictors of intention in both samples, with attitudes predicting intention in the Australia sample and risk perceptions predicting intention in the US sample. Significant indirect effects of social cognition constructs through intentions were observed. Inclusion of past behavior attenuated model effects. Multigroup analysis revealed no differences in model fit across samples, suggesting that observed variations in the parameter estimates were relatively trivial.ConclusionResults indicate that social distancing is a function of motivational and volitional processes. This knowledge can be used to inform messaging regarding social distancing during COVID‐19 and in future pandemics.
Comprehensive genomic profiling for patients with chemotherapy‐naïve advanced cancer
Authors: Kondo Tomohiro , Matsubara Junichi , Quy Pham Nguyen , Fukuyama Keita , Nomura Motoo , Funakoshi Taro , Doi Keitaro , Sakamori Yuichi , Yoshioka Masahiro , Yokoyama Akira , Tamaoki Masashi , Kou Tadayuki , Hirohashi Kenshiro , Yamada Atsushi , Yamamoto Yoshihiro , Minamiguchi Sachiko , Nishigaki Masakazu , Yamada Takahiro , Kanai Masashi , Matsumoto Shigemi , Muto Manabu 
Published: October 2020

AbstractComprehensive genomic profiling (CGP) testing by next‐generation sequencing has been introduced into clinical practice as part of precision cancer medicine to select effective targeted therapies. However, whether CGP testing at the time of first‐line chemotherapy could be clinically useful is not clear. We conducted this single‐center, prospective, observational study to investigate the feasibility of CGP testing for chemotherapy‐naïve patients with stage III/IV gastrointestinal cancer, rare cancer, and cancer of unknown primary, using the FoundationOne®companion diagnostic (F1CDx) assay. The primary outcome was the detection rate of at least one actionable/druggable cancer genomic alteration. Actionable/druggable cancer genomic alterations were determined by the F1CDx report. An institutional molecular tumor board determined the molecular‐based recommended therapies. A total of 197 patients were enrolled from October 2018 to June 2019. CGP success rate was 76.6% (151 of 197 patients), and median turnaround time was 19 days (range: 10‐329 days). Actionable and druggable cancer genomic alterations were reported in 145 (73.6%) and 124 (62.9%) patients, respectively. The highest detection rate of druggable genomic alterations in gastrointestinal cancers was 80% in colorectal cancer (48 of 60 patients). Molecular‐based recommended therapies were determined in 46 patients (23.4%). CGP testing would be a useful tool for the identification of a potentially effective first‐line chemotherapy.
A mixed‐methods analysis of younger adults' perceptions of asthma, self‐management, and preventive care: "This isn't helping me none"
Authors: Mammen Jennifer R. , Turgeon Kelsey , Philibert Ashley , Schoonmaker Judith D. , Java James , Halterman Jill , Berliant Marc N. , Crowley Amber , Reznik Marina , Feldman Jonathan M. , Fortuna Robert J. , Arcoleo Kimberly 
Published: October 2020

AbstractBackgroundYoung adults (ages 18‐44) have increased emergency department use for asthma and poor adherence to medications. The objective of this mixed‐methods study was to understand experiences with and approaches to managing asthma, of which little is known in this age group.MethodsSurveys (Asthma Control Questionnaire, Asthma Quality of Life Questionnaire) and 1:1 semi‐structured interviews were used to explore experiences with asthma, symptoms, self‐management behaviours, and relationship to asthma control and quality of life. Qualitative data were analysed using content analysis techniques. Descriptive statistics and bivariate correlations were used to examine distributive characteristics and associations between variables.ResultsForty urban adults participated (mean age 32.7 ± 6.2, 1σ). Coughing was reported nearly 46% more often than wheezing, with 42.5% (17/40) coughing until the point of vomiting most days. Most participants delayed using medication for symptoms due to misperceptions about inhalers. Higher symptom frequency and worse asthma control were associated with greater use of non‐pharmacologic symptom management strategies (r = 0.645, P < .001; r = 0.360, P = .022, respectively). Five themes were identified regarding young adults experiences with asthma: (1) having asthma means being limited and missing out on life; (2) health care for asthma is burdensome, and other things are more important; (3) there is not enough personal benefit in medical interactions to make preventive care worthwhile; (4) there are insufficient support and education about asthma for adults; and (5) people normalize chronic symptoms over time and find ways of coping that fit with their lifestyle.Conclusions and Clinical RelevanceYoung adults may tolerate symptoms without using quick‐relief medication or seeking preventive care. Increasing engagement with preventive services will require decreasing perceived burdens and increasing the personal benefits of care. Evaluating for non‐pharmacologic approaches to managing symptoms and asthma‐related coughing may identify uncontrolled asthma. Enhanced training for clinicians in patient‐centric asthma care may be needed.
Reference value of perimeter‐derived diameter assessed by three‐dimensional transesophageal echocardiography in left atrial appendage occluder size selection
Authors: Kong Dehong , Jiang Yingying , Zhang Xiaochun , Jin Qinchun , Dong Lili , Zhou Daxin , Shu Xianhong , Pan Cuizhen 
Published: October 2020

AbstractBackgroundThe aim of this study was to investigate the utility of perimeter‐derived diameter (PDD) measured by three‐dimensional (3D) transesophageal echocardiography (TEE) in predicting the size of left atrial appendage (LAA) occluder.Methods and resultsLeft atrial appendage landing zone diameter (LZD) was measured by two‐dimensional (2D) TEE, 3DTEE, and digital subtraction angiography (DSA) as LZD‐2Dmax, LZD‐2Dmean, LZD‐3Dmax, LZD‐3Dmean, LZD‐PDD, LZD‐DSAmax, respectively, before and during transcatheter LAA closure with Watchman devices in 100 patients. A difference of one or more device size intervals between the predicted size and the size actually implanted was defined as mismatching. Seventy‐eight patients were followed up by TEE to obtain occluder compression ratio. The correlation between LZD and the final implanted occluder size was 0.559, 0.641, 0.754, 0.760, 0.782, and 0.848 for LZD‐2Dmax, LZD‐2Dmean, LZD‐3Dmax, LZD‐3Dmean, LZD‐PDD and LZD‐DSAmax, respectively (P < .001). Matching ratio between the size predicted by retrospective measurements of LZD and the device size actually implanted was 65%, 57%, 66%, 63%, 70%, and 83% for LZD‐2Dmax, LZD‐2Dmean, LZD‐3Dmax, LZD‐3Dmean, LZD‐PDD and LZD‐DSAmax, respectively. There was no significant difference in LZD value, matching ratio, and compression ratio between the patients with eccentric and noneccentric LAA landing zone (P > .05). Compression ratio of the mismatching subjects was higher than that in the matching subjects when evaluated by LZD‐2Dmean, LZD‐3Dmean, and LZD‐PDD (P < .05).ConclusionsLanding zone diameter derived from LAA perimeter measured by preprocedure 3DTEE showed reference value for LAA occluder size selection, providing superior correlation and matching ratio with the final implanted size and indicating the adjustment of oversizing.
Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons
Authors: Schraut Karla‐Gerlinde , Kalnytska Oleksandra , Lamp Daniel , Jastroch Martin , Eder Matthias , Hausch Felix , Gassen Nils C. , Moore Sarah , Nagaraj Nagarjuna , Lopez Juan P. , Chen Alon , Schmidt Mathias V. 
Published: October 2020

AbstractMajor depressive disorder (MDD) is one of the most severe global health problems with millions of people affected, however, the mechanisms underlying this disorder is still poorly understood. Genome‐wide association studies have highlighted a link between the neutral amino acid transporter SLC6A15 and MDD. Additionally, a number of preclinical studies support the function of this transporter in modulating levels of brain neurotransmitters, stress system regulation and behavioural phenotypes related to MDD. However, the molecular and functional mechanisms involved in this interaction are still unresolved. Therefore, to investigate the effects of the SLC6A15 transporter, we used hippocampal tissue from Slc6a15‐KO and wild‐type mice, together with several in‐vitro assays in primary hippocampal neurons. Utilizing a proteomics approach we identified differentially regulated proteins that formed a regulatory network and pathway analysis indicated significantly affected cellular domains, including metabolic, mitochondrial and structural functions. Furthermore, we observed reduced release probability at glutamatergic synapses, increased mitochondrial function, higher GSH/GSSG redox ratio and an improved neurite outgrowth in primary neurons lacking SLC6A15. In summary, we hypothesize that by controlling the intracellular concentrations of neutral amino acids, SLC6A15 affects mitochondrial activity, which could lead to alterations in neuronal structure and activity. These data provide further indication that a pharmacological or genetic reduction of SLC6A15 activity may indeed be a promising approach for antidepressant therapy.
Coordination of social behaviors by the bed nucleus of the stria terminalis
Authors: Flanigan Meghan E. , Kash Thomas L. 
Published: October 2020

AbstractThe bed nucleus of the stria terminalis (BNST) is a sexually dimorphic, neuropeptide‐rich node of the extended amygdala that has been implicated in responses to stress, drugs of abuse, and natural rewards. Its function is dysregulated in neuropsychiatric disorders that are characterized by stress‐ or drug‐induced alterations in mood, arousal, motivation, and social behavior. However, compared to the BNST’s role in mood, arousal, and motivation, its role in social behavior has remained relatively understudied. Moreover, the precise cell types and circuits underlying the BNST’s role in social behavior have only recently begun to be explored using modern neuroscience techniques. Here, we systematically review the existing literature investigating the neurobiological substrates within the BNST that contribute to the coordination of various sex‐dependent and sex‐independent social behavioral repertoires, focusing largely on pharmacological and circuit‐based behavioral studies in rodents. We suggest that the BNST coordinates social behavior by promoting appropriate assessment of social contexts to select relevant behavioral outputs and that disruption of socially relevant BNST systems by stress and drugs of abuse may be an important factor in the development of social dysfunction in neuropsychiatric disorders.