bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Material Strength on Ductile Failure of Steel in Pressure Vessel Design
Authors: Baghous N. , Barsoum I. 
Published: August 2020

Abstract
Pressure vessels and their components are commonly designed with the ASME Boiler and Pressure Vessel Codes. One of the requirements when pursuing the design by analysis route is to design these equipment against ductile local failure criterion provided in the codes. However, the ductile local failure criterion in the ASME codes only accounts for the stress triaxiality (T) as a stress state measure. Recent work has shown that ductile failure highly depends on the stress state characterized by both T and the Lode parameter L, which is related to the third deviatoric stress invariant. In this study, the effect of stress state characterized by both T and L is investigated for six different steel grades with different material strength levels. To establish the ductile failure loci for the six steel grades with respect to T and L, experiments were conducted on two different specimen geometries. The L parameter is controlled by the specimen configuration, where the round notched bar specimen corresponds to axisymmetric tensile conditions (L = −1) and the flat notched specimen corresponds to plane strain loading conditions (L = 0), whereas T is controlled by introducing a notch at the center of the specimens. A Lode sensitivity parameter (LS) is defined based on the experimental results and revealed that the steel grades with ultimate strength higher than a certain threshold value (450 MPa) exhibit sensitivity to the Lode parameter. The Lode sensitivity was quantified, and the results showed that the LS increases with increase in the ultimate strength of the steel grade. The results were incorporated to enhance the original ASME local failure criterion by accounting for T, L, and LS to accurately assess ductile failure in high-strength steels. The application of the enhanced failure locus in a design analysis of a pressure vessel made of a high-strength steel grade is demonstrated, which showed that the original ASME criterion, as compared to the enhanced criterion in this study, is not capable of predicting ductile failure and hence rendering a rather nonconservative design. It is concluded that the enhanced local failure criterion is recommended to be used for the design of pressure vessels and their components made of steel grades with an ultimate strength higher than the threshold value.
Could Relative Movement Between the Adductor Muscles and the Skin Invalidate Surface Electromyography Measurement?
Authors: Elsais Walaa M. , Preece Stephen J. , Jones Richard K. , Herrington Lee 
Published: August 2020

The superficial hip adductor muscles are situated in close proximity to each other. Therefore, relative movement between the overlying skin and the muscle belly could lead to a shift in the position of surface electromyography (EMG) electrodes and contamination of EMG signals with activity from neighboring muscles. The aim of this study was to explore whether hip movements or isometric contraction could lead to relative movement between the overlying skin and 3 adductor muscles: adductor magnus, adductor longus, and adductor gracilis. The authors also sought to investigate isometric torque–EMG relationships for the 3 adductor muscles. Ultrasound measurement showed that EMG electrodes maintained a position which was at least 5 mm within the muscle boundary across a range of hip flexion–extension angles and across different contraction levels. The authors also observed a linear relationship between torque and EMG amplitude. This is the first study to use ultrasound to track the relative motion between skin and muscle and provides new insight into electrode positioning. The findings provide confidence that ultrasound-based positioning of EMG electrodes can be used to derive meaningful information on output from the adductor muscles and constitute a step toward recognized guidelines for surface EMG measurement of the adductors.
Potential Mechanisms of the Alexander Technique: Toward a Comprehensive Neurophysiological Model
Authors: Cacciatore Timothy W. , Johnson Patrick M. , Cohen Rajal G. 
Published: August 2020

The Alexander technique (AT) has been practiced for over 125 years. Despite evidence of its clinical utility, a clear explanation of how AT works is lacking, as the foundational science needed to test the underlying ideas has only recently become available. The authors propose that the core changes brought about by Alexander training are improvements in the adaptivity and distribution of postural tone, along with changes in body schema, and that these changes underlie many of the reported benefits. They suggest that AT alters tone and body schema via spatial attention and executive processes, which in turn affect low-level motor elements. To engage these pathways, AT strategically engages attention, intention, and inhibition, along with haptic communication. The uniqueness of the approach comes from the way these elements are woven together. Evidence for the contribution of these elements is discussed, drawing on direct studies of AT and other relevant modern scientific literature.
Mesoproterozoic–Early Cretaceous provenance and paleogeographic evolution of the Northern Rocky Mountains: Insights from the detrital zircon record of the Bridger Range, Montana, USA
Authors: Ronemus Chance B. , Orme Devon A. , Campbell Saré , Black Sophie R. , Cook John 
Published: August 2020

AbstractThe Bridger Range of southwest Montana, USA, preserves one of the most temporally extensive sedimentary sections in North America, with strata ranging from Mesoproterozoic to Cretaceous in age. This study presents new detrital zircon geochronologic data from eight samples collected across this mountain range. Multidimensional scaling and non-negative matrix factorization statistical analyses are used to quantitatively unmix potential sediment sources from these and 54 samples compiled from previous studies on regional correlative strata. We interpret these sources based on reference data from preserved strata with detrital zircon signatures likely representative of ancient sediment sources. We link these sources to their sinks along sediment dispersal pathways interpreted using available paleogeographic constraints. Our results show that Mesoproterozoic strata in southwest Montana contain detritus derived from the nearby craton exposed along the southern margin of the fault-bounded Helena Embayment. Middle Cambrian strata were dominated by the recycling of local sources eroded during the development of the Great Unconformity. In Devonian–Pennsylvanian time, provenance in southwest Montana shifted to more distal sources along the northeastern to southeastern margins of Laurentia, but more western basins received detritus from outboard sources along a tectonically complicated margin. By the Late Jurassic, provenance in the developing retroarc foreland basin system was dominated by Cordilleran magmatic arcs and fold-thrust belt sources to the west. Eastward propagation of the fold-thrust belt caused recycling of Paleozoic and Jurassic detritus into the foreland basin to dominate by the Early Cretaceous.
Ocean acidification during the early Toarcian extinction event: Evidence from boron isotopes in brachiopods
Authors: Müller Tamás , Jurikova Hana , Gutjahr Marcus , Tomašových Adam , Schlögl Jan , Liebetrau Volker , Duarte Luís v. , Milovský Rastislav , Suan Guillaume , Mattioli Emanuela , Pittet Bernard , Eisenhauer Anton 
Published: August 2020

Abstract
The loss of carbonate production during the Toarcian Oceanic Anoxic Event (T-OAE, ca. 183 Ma) is hypothesized to have been at least partly triggered by ocean acidification linked to magmatism from the Karoo-Ferrar large igneous province (southern Africa and Antarctica). However, the dynamics of acidification have never been directly quantified across the T-OAE. Here, we present the first record of temporal evolution of seawater pH spanning the late Pliensbachian and early Toarcian from the Lusitanian Basin (Portugal) reconstructed on the basis of boron isotopic composition (δ11B) of brachiopod shells. δ11B declines by ∼1‰ across the Pliensbachian-Toarcian boundary (Pl-To) and attains the lowest values (∼12.5‰) just prior to and within the T-OAE, followed by fluctuations and a moderately increasing trend afterwards. The decline in δ11B coincides with decreasing bulk CaCO3 content, in parallel with the two-phase decline in carbonate production observed at global scales and with changes in pCO2 derived from stomatal indices. Seawater pH had declined significantly already prior to the T-OAE, probably due to the repeated emissions of volcanogenic CO2. During the earliest phase of the T-OAE, pH increased for a short period, likely due to intensified continental weathering and organic carbon burial, resulting in atmospheric CO2 drawdown. Subsequently, pH dropped again, reaching the minimum in the middle of the T-OAE. The early Toarcian marine extinction and carbonate collapse were thus driven, in part, by ocean acidification, similar to other Phanerozoic events caused by major CO2 emissions and warming.
Precipitation and aridity constraints from paleolakes on early Mars
Authors: Stucky de Quay Gaia , Goudge Timothy A. , Fassett Caleb I. 
Published: August 2020

AbstractThe ancient climate of Mars remains an enigma despite the abundance of in situ and remote-sensing data revealing hydrological activity in the past. The crux of this debate—informed by geomorphic studies, chemical alteration observations, and numerical climate models—is the amount, distribution, and nature of surface water and precipitation (i.e., rain vs. snow). Here, we combined measurements of 96 open- and closed-basin lakes with simple hydrological balances to constrain catchment-averaged precipitation, PT, integrated over a given runoff episode of indeterminate length during early Mars history. We included 13 systems containing both open- and closed-basin lakes, providing fully bounded precipitation estimates (coupled systems). We show that, on average, PT was ≳4 m and ≲159 m; however, local precipitation was spatially variable and consistent with a complex, planetwide climate. Aridity indexes of open-basin lakes indicate some regions may have been at least as humid as semiarid terrestrial environments. Our results offer widely distributed, quantitative hydro-climate constraints that can be used to test paleoclimate model scenarios, working toward bridging the gap between geological observations and climate theory for early Mars.
Service evaluation of laceration risk using trainer adrenaline auto-injectors
Authors: Pike Louise Charlotte , Tuthill David 
Published: August 2020

ObjectiveAnaphylaxis is a severe, potentially fatal allergic reaction best treated with intramuscular epinephrine via epinephrine auto-injectors (AAIs). Our published concerns over laceration injuries to young children associated with AAIs led to this service evaluation of the two administration methods: swing and jab (S&J) and place and press (P&P), to determine potential laceration risk.DesignA trainer EpiPen was used with facepaint placed in the needle indentation which would record the length of movement of the AAI. The two different methods ‘administered’ were alternated. Children were asked to move their leg to simulate a withdrawal reaction. Age, whether they moved, and length of paint mark were recorded.SettingOutpatients waiting area in Noah’s Ark Children’s Hospital, Cardiff.ParticipantsChildren aged 5–11 with no prior knowledge of AAI use.InterventionNo intervention was implemented.Results135 children (mean age 8 years; range 5–11 years) were asked to participate; measurements were taken from 100 children. 50 children moved for one or both methods. For those that moved, S&J mean paint length=8.3 mm (SD 17.4, 95% CI 3.4 to 13.3), P&P mean=3.5 mm (SD 11.0, 95% CI 0.4 to 6.6). Mean difference between methods was 4.8 mm (SD 10.1, 95% CI 1.9 to 7.7). Slightly more children moved for S&J (44) compared with 38 for P&P.ConclusionsS&J produces more movement and longer paint marks than P&P. The risk of laceration when administering an EpiPen to young children may be lower by using the more controlled P&P. We feel it is advisable to teach P&P instead in children below 11 years of age.
Aerobic performance among healthy (non-asthmatic) adults using beta2-agonists: a systematic review and meta-analysis of randomised controlled trials
Authors: Riiser Amund , Stensrud Trine , Stang Julie , Andersen Lars Bo 
Published: August 2020

ObjectiveTo examine the effect of beta2-agonists on aerobic performance in healthy, non-asthmatic study participants.DesignSystematic review and meta-analysis.Eligibility criteriaWe searched four databases (PubMed, Embase, SPORTDiscus and Web of Science) for randomised controlled trials published until December 2019. Studies examining the effect of beta2-agonists on maximal physical performance lasting longer than 1 min were included in the meta-analysis. Data are presented as standardised difference in mean (SDM) with 95% CI.ResultsThe present meta-analysis includes 47 studies. The studies comprise 607 participants in cross-over trials, including 99 participants in three-way cross-over trials and 27 participants in a four-way cross-over trial. Seventy-three participants were included in parallel trials. Beta2-agonists did not affect aerobic performance compared with placebo (SDM 0.051, 95% CI −0.020 to 0.122). The SDM for the included studies was not heterogeneous (I2=0%, p=0.893), and the effect was not related to type of beta2-agonist, dose, administration route, duration of treatment or performance level of participants. Beta2-agonists had no effect on time trial performance, time to exhaustion or maximal oxygen consumption (p<0.218).Conclusion/implicationThe present study shows that beta2-agonists do not affect aerobic performance in non-asthmatic subjects regardless of type, dose, administration route, duration of treatment or performance level of participants. The results of the present study should be of interest to WADA and to anyone who is interested in equal opportunities in competitive sports.Systematic review registrationPROSPERO CRD42018109223.
Changes in medication administration error rates associated with the introduction of electronic medication systems in hospitals: a multisite controlled before and after study
Authors: Westbrook Johanna I , Sunderland Neroli S , Woods Amanda , Raban Magdalena Z , Gates Peter , Li Ling 
Published: August 2020

BackgroundElectronic medication systems (EMS) have been highly effective in reducing prescribing errors, but little research has investigated their effects on medication administration errors (MAEs).ObjectiveTo assess changes in MAE rates and types associated with EMS implementation.MethodsThis was a controlled before and after study (three intervention and three control wards) at two adult teaching hospitals. Intervention wards used an EMS with no bar-coding. Independent, trained observers shadowed nurses and recorded medications administered and compliance with 10 safety procedures. Observational data were compared against medication charts to identify errors (eg, wrong dose). Potential error severity was classified on a 5-point scale, with those scoring ≥3 identified as serious. Changes in MAE rates preintervention and postintervention by study group, accounting for differences at baseline, were calculated.Results7451 administrations were observed (4176 pre-EMS and 3275 post-EMS). At baseline, 30.2% of administrations contained ≥1 MAE, with wrong intravenous rate, timing, volume and dose the most frequent. Post-EMS, MAEs decreased on intervention wards relative to control wards by 4.2 errors per 100 administrations (95% CI 0.2 to 8.3; p=0.04). Wrong timing errors alone decreased by 3.4 per 100 administrations (95% CI 0.01 to 6.7; p<0.05). EMS use was associated with an absolute decline in potentially serious MAEs by 2.4% (95% CI 0.8 to 3.9; p=0.003), a 56% reduction in the proportion of potentially serious MAEs. At baseline, 74.1% of administrations were non-compliant with ≥1 of 10 procedures and this rate did not significantly improve post-EMS.ConclusionsImplementation of EMS was associated with a modest, but significant, reduction in overall MAE rate, but halved the proportion of MAEs rated as potentially serious.
‘Sometimes you are forced to play God…’: a qualitative study of healthcare worker experiences of using continuous positive airway pressure in newborn care in Kenya
Authors: Nabwera Helen M , Wright Jemma L , Patil Manasi , Dickinson Fiona , Godia Pamela , Maua Judith , Sammy Mercy K , Naimoi Bridget C , Warfa Osman H , Dewez Juan Emmanuel , Murila Florence , Manu Alexander , Smith Helen , Mathai Matthews 
Published: August 2020

​ObjectiveTo explore the experiences of using continuous positive airway pressure (CPAP) in newborn care among healthcare workers in Kenya, and to identify factors that would promote successful scale-up.​Design and settingA qualitative study using key informant interviews and focus group discussions, based at secondary and tertiary level hospitals in Kenya.​ParticipantsHealthcare workers in the newborn units providing CPAP.​Primary and secondary outcome measureFacilitators and barriers of CPAP use in newborn care in Kenya.​Results16 key informant interviews and 15 focus group discussions were conducted across 19 hospitals from September 2017 to February 2018. Main barriers reported were: (1) inadequate infrastructure to support the effective delivery of CPAP, (2) shortage of skilled staff rendering it difficult for the available staff to initiate or monitor infants on CPAP and (3) inadequate knowledge and training of staff that inhibited the safe care of infants on CPAP. Key facilitators reported were positive patient outcomes after CPAP use that increased staff confidence and partnership with caregivers in the management of newborns on CPAP. Healthcare workers in private/mission hospitals had more positive experiences of using CPAP in newborn care as the relevant support and infrastructure were available.​ConclusionCPAP use in newborn care is valued by healthcare workers in Kenya. However, we identified key challenges that threaten its safe use and sustainability. Further scale-up of CPAP in newborn care should ensure that staff members have ready access to optimal training on CPAP and that there are enough resources and infrastructure to support its use.EthicsThis study was approved through the appropriate ethics committees in Kenya and the UK (see in text) with written informed consent for each participant.
Health programmes and services addressing the prevention and management of infectious diseases in persons who inject drugs in Canada: a systematic integrative review protocol
Authors: Alvarez Elizabeth , Joshi Siddharth , Lokker Cynthia , Wang Annie , Pavalagantharajah Sureka , Qiu Yun , Sidhu Hargun , Mbuagbaw Lawrence , Qutob Majdi , Henedi Alia , Levine Mitchell , Lennox Robin , Tarride Jean-Eric , Kalina Dale 
Published: August 2020

IntroductionInjection drug use (IDU) and intravenous drug use (IVDU) are of concern to the people using drugs, their families and health systems. One of the complications of IDU/IVDU is the risk of infection. Clinical experience has shown that persons who inject drugs (PWID) are hospitalised and re-hospitalised frequently. In Canada there are sparse data about the reasons for which PWID are admitted to hospital and their health trajectories, especially for infectious diseases. There are special concerns regarding PWID with infections who leave the hospital against medical advice and those who leave with a peripherally inserted central catheter line in place for administration of long-term antibiotics or other therapies. Improving our understanding of current programmes and services addressing the prevention and management of infectious diseases and their complications in PWID could lead to focused interventions to enhance care in this population.Methods and analysisAn integrative systematic review allows for inclusion of a variety of methodologies to understand a health issue from different viewpoints. PubMed, CINAHL, Web of Science Databases and websites of the Public Health Agency of Canada, Canadian Institute for Substance Use Research, and Canadian Centre on Substance Use and Addiction will be searched using terms for infectious diseases, drug use and geography (Canada) and limited to the last 10 years (2009–2019). The Quality Appraisal Tool in Studies with Diverse Designs will be used to appraise the quality of identified studies and documents. Quantitative, qualitative or mixed methods data synthesis will be used as needed.Ethics and disseminationThis study is a secondary analysis of publicly available documents; therefore, no ethics approval is required. This information will inform a research agenda to further investigate interventions that aim to address these issues.PROSPERO registration numberCRD42020142947.
Impact of incremental versus conventional initiation of haemodialysis on residual kidney function: study protocol for a multicentre feasibility randomised controlled trial
Authors: Kaja Kamal Raja Mohammed , Farrington Ken , Wellsted David , Sridharan Sivakumar , Alchi Bassam , Burton James , Davenport Andrew , Vilar Enric 
Published: August 2020

IntroductionPreserving residual kidney function (RKF) may be beneficial to patients on haemodialysis (HD) and it has been proposed that commencing dialysis incrementally rather than three times a week may preserve RKF. In Incremental HD, target dose includes a contribution from RKF, which is added to HD dose, allowing individualisation of the HD prescription. We will conduct a feasibility randomised controlled trial (RCT) comparing incremental HD and conventional three times weekly treatments in incident HD patients. The study is designed also to provide pilot data to allow determination of effect size to power a definitive study.Methods and analysisAfter screening to ensure native renal urea clearance >3 mL/min/1.73 m2, the study will randomise 54 patients within 3 months of HD initiation to conventional in-centre thrice weekly dialysis or incremental in-centre HD commencing 2 days a week. Subjects will be followed up for 12 months. The study will be carried out across four UK renal centres.The primary outcome is to evaluate the feasibility of conducting a definitive RCT and to estimate the difference in rate of decline of RKF between the two groups at 6 and 12 months time points. Secondary outcomes will include the impact of dialysis intensity on vascular access events, major adverse cardiac events and survival. Impact of dialysis intensity on patient-reported outcomes measures, cognition and frailty will be assessed using EQ-5D-5L, PHQ-9, Illness Intrusiveness Rating Score, Montreal Cognitive assessment and Clinical Frailty Score. Safety outcomes include hospitalisation, fluid overload episodes, hyperkalaemia events and vascular access events.This study will inform the design of a definitive study, adequately powered to determine whether RKF is better preserved after incremental HD initiation compared with conventional initiation.Ethics and disseminationEthics approval has been granted by Cambridge South Research Ethics Committee, United Kingdom(REC17/EE/0311). Results will be disseminated via peer-reviewed publication.Trial registration numberNCT03418181