bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rectal gonorrhoea and chlamydia among men who have sex with men in coastal Kenya
Authors: Ngetsa Caroline J. , Heymann Marc W. , Thiong'o Alex , Wahome Elizabeth , Mwambi John , Karani Clara , Menza Nelson C. , Mwashigadi Grace , Muturi Margaret W. , Graham Susan M. , Mugo Peter M. , Sanders Eduard J. 
Published: December 2019

Background: Men who have sex with men (MSM) have a higher prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections compared to the rest of the population, often remaining undiagnosed. In Kenya, prevalence of rectal CT and NG infection and NG antimicrobial sensitivity are poorly described. Methods: MSM who reported receptive anal intercourse (RAI) were recruited from an ongoing human immunodeficiency virus acquisition and treatment study in coastal Kenya in 2016-2017. Rectal swabs were collected at two time points 6 months apart to estimate prevalence and incidence of CT/NG infection using a molecular point-of-care assay. Participants positive for CT or NG were treated according to national guidelines. NG culture and antimicrobial susceptibility testing was performed. Participant and risk behaviour characteristics were collected and association with baseline CT/NG prevalence assessed by multivariable regression analysis. Results: Prevalence of CT/NG in 104 MSM was 21.2% (CT 13.5%, NG 9.6%, dual infection 1.9%) at baseline and 25.9% in 81 MSM at follow-up (CT 14.8%, NG 14.8%, dual infection 3.7%). CT/NG incidence was estimated at 53.0 (95% CI, 34.5-81.3) per 100 person-years. Most CT/NG positive participants were asymptomatic: 95.5% at baseline and 100% at follow-up. CT/NG infection was associated with being paid for sex [adjusted odds ratio (aOR)=6.2, 95% CI (1.7-22.9)] and being in formal employment [aOR=7.5, 95% CI (1.1-49.2)]. Six NG isolates were obtained at follow-up; all were susceptible to ceftriaxone and cefixime and all were resistant to penicillin, tetracycline and ciprofloxacin. Conclusions: There is a high prevalence and incidence of asymptomatic rectal CT and NG in MSM reporting RAI in coastal Kenya. MSM who were paid for sex or had formal employment were more likely to be infected with CT/NG suggesting increased risk behaviour during transactional sex. Antimicrobial susceptibility results suggest that current antibiotic choices in Kenya are appropriate for NG treatment.
Aplicación tópica de crema con nanopartículas con vitamina E para prevenir radiodermatitis en cáncer de mama: protocolo de ensayo clínico
Authors: Schmidt Fernanda Mateus Queiróz , González Carol V. Serna , Mattar Rodrigo Calixto , Lopes Luciana Biagini , Santos Marinilce Fagundes dos , de Gouveia Santos Vera L.C. 
Published: December 2019

Sinopsis: Objetivo: Poco se conoce sobre la eficacia de productos para la prevención de radiodermatitis, que afecta al 90–95% de las mujeres con cáncer de mama. El uso de antioxidantes es promisorio, sin embargo, poco estudiado. Los autores desarrollaron un protocolo de ensayo clínico para evaluar el efecto potencial de la aplicación de crema con nanopartículas con vitamina E para prevenir radiodermatitis aguda en mujeres con cáncer de mama. Método: El protocolo sugiere que 108 mujeres adultas con cáncer de mama, que estén recibiendo radioterapia, sean incluidas en este ensayo clínico, controlado, aleatorizado y triple ciego, en un hospital oncológico. Se prevé la distribución de pacientes en tres grupos de 36 personas: el grupo A recibirá una crema con nanopartículas lipídicas con vitamina E, el grupo B obtendrá una crema sin nanopartículas ni vitamina E, y el grupo C usará una crema con nanopartículas sin vitamina E. Los resultados primarios evaluarán la incidencia, el grado y el tiempo de surgimiento de la radiodermatitis. Los resultados secundarios se centrarán en la calidad de vida, los síntomas y la temperatura local. Las pacientes serán evaluadas tres veces por semana, desde el inicio de la radioterapia hasta dos semanas después de la última sesión. El presente proyecto fue aprobado por el comité de ética en investigación de las instituciones involucradas.
Supportive technology in collaborative research: proposing the STiCR framework
Authors: Kwasnicki RM , Cato LD , Geoghegan L , Stanley G , Pancholi J , Jain A , Gardiner MD 
Published: December 2019

Introduction Achieving a standard of clinical research at the pinnacle of the evidence pyramid is historically expensive and logistically challenging. Research collaboratives have delivered high-impact prospective multicentre audits and clinical trials by using trainee networks with a range of enabling technology. This review outlines such use of technology in the UK and provides a framework of recommended technologies for future studies. Methods A review of the literature identified technology used in collaborative projects. Additional technologies were identified through web searches. Technologies were grouped into themes including access (networking and engagement), collaboration and event organisation. The technologies available to support each theme were studied further to outline relative benefits and limitations. Findings Thirty-three articles from trainee research collaboratives were identified. The most frequently documented technologies were social media applications, website platforms and research databases. The Supportive Technologies in Collaborative Research framework is proposed, providing a structure for using the technologies available to support multicentre collaboration. Such technologies are often overlooked in the literature by established and start-up collaborative project groups. If used correctly, they might help to overcome the physical, logistical and financial barriers of multicentre clinical trials.
Optimization study of metallic sub-wavelength gratings as the polarizer in infrared wavelengths
Authors: Yang Zongyao , Feng Bo , Lu Bingrui , Chen Yifang , Li Wenhao , Zhang Wei , Li Tao 
Published: December 2019

Despite the polarimetric detection in the infrared wavelengths of 8–10 µm being of great importance and broad applications, there has been limited addressing of the grating-based polarizers in this band. One of the main issues lies in the process incompatibility between the conventional nanofabrication technique and the II-VI materials such as HgCdTe, so that the direct integration of polarizers with sensors still remains a big challenge. This paper reports our recent work on optimizing the grating structures, materials, and nanofabrication processes for enhancing both the transmittance and the extinction ratio of polarizers on Si and/or ZnSe wafers, using numerical simulations for the grating design and electron beam lithography for the nanoscale pattern generation. By utilizing the finite-difference time-domain method, both the transmittance and the extinction ratio are maximized by optimizing the grating geometric dimensions and the duty cycle for two different grating materials of Al and Au for comparison. Based on the designed structures, nanofabrications of sub-wavelength gratings in both Al and Au are carried out, and the processes are compared for achieving high polarization performance. Optical characterizations of the fabricated polarizers demonstrate that both high transmittance and extinction ratio can be achieved in feasible parameters and the nano-process developed in this work.
Dual frequency comb assisted analog-to-digital conversion
Authors: Deakin Callum , Liu Zhixin 
Published: December 2019

Photonic analog to digital conversion offers promise to overcome the signal-to-noise ratio and sample rate trade-off in conventional analog to digital converters (ADCs), critical for modern digital communications and signal analysis. We propose using phase-stable dual frequency combs with a fixed frequency spacing offset to downconvert spectral slices of a broadband signal and enable high-resolution parallel digitization. To prove the concept of our proposed method, we demonstrate the detection of a 10 GHz subcarrier modulated (SCM) signal using 500 MHz bandwidth ADCs by optically converting the SCM signal to 10 1 GHz bandwidth signals that can be processed in parallel for full signal detection and reconstruction. Using sinusoidal-wave-based standard ADC testing, we demonstrate a spurious-free dynamic range of

>

45

d
B

and signal-to-noise-and-distortion of

>

20

d
B

, limited by the receiver front-end design.
Mode-locked and tunable fiber laser at the 3.5  µm band using frequency-shifted feedback
Authors: Henderson-Sapir Ori , Bawden Nathaniel , Majewski Matthew R. , Woodward Robert I. , Ottaway David J. , Jackson Stuart D. 
Published: December 2019

We report on a mid-infrared mode-locked fiber laser that uses an acousto-optic tunable filter to achieve frequency-shifted feedback pulse generation with frequency tuning over a 215 nm range. The laser operates on the 3.5 µm transition in erbium-doped zirconium fluoride-based fiber and utilizes the dual-wavelength pumping scheme. Stable, self-starting mode locking with a minimum pulse duration of 53 ps was measured using a two-photon absorption autocorrelator. The longest wavelength demonstrated was 3612 nm, and the maximum average powers achieved were 50 and 167 mW in fundamental and multi-pulse mode-locking regimes, respectively. To the best of our knowledge, this is the longest wavelength rare-earth-doped mode-locked fiber laser demonstrated. The broad tunability promises potential uses for environmental sensing applications.
Fe3O4 nanoparticles as a saturable absorber for a tunable Q-switched dysprosium laser around 3  μm
Authors: Yang Jian , Hu Jiyi , Luo Hongyu , Li Jianfeng , Liu Jishu , Li Xiaohui , Liu Yong 
Published: December 2019

We demonstrate for the first time to our knowledge the use of

Fe

3

O

4

nanoparticles for

Q

-switching a tunable mid-infrared (Mid-IR)

Dy

3
+

-doped ZBLAN fiber laser around 3 μm. The

Q

-switcher was fabricated by depositing the prepared

Fe

3

O

4

nanoparticles solution onto an Au mirror. Its nonlinear optical response was characterized using a mode locked

Ho

3
+

/

Pr

3
+

-codoped ZBLAN fiber laser at 2.87 μm, and showed a modulation depth of 11.9% as well as a saturation intensity of

1.44

MW
/

cm

2

. Inserting the device into a tunable

Dy

3
+

-doped ZBLAN fiber laser, stable

Q

-switched pulses within the tunable range of 2812.4–3031.6 nm were obtained. When tuning the wavelength to 2931.2 nm, a maximum

Q

-switching output power of 111.0 mW was achieved with a repetition rate of 123.0 kHz and a pulse width of 1.25 μs. The corresponding pulse energy was 0.90 μJ. This demonstration suggests that

Fe

3

O

4

nanoparticles are a promising broadband saturable absorption material for mid-infrared operation.
Los estudios reglados de comunicación en las universidades del ranking de Shangai. Propuestas para una epistemología de las ciencias de la comunicación
Authors: Marzal-Felici Javier , Soler-Campillo Maria , Rodríguez-Serrano Aaron 
Published: December 2019

El presente artículo propone una reflexión crítica sobre el estatuto y naturaleza de los estudios de comunicación en el contexto académico español. En primer lugar, se examina la situación de los estudios de comunicación, que las autoridades académicas españolas han establecido unívocamente en la rama de “ciencias sociales y jurídicas”, más concretamente en el ámbito de las ciencias sociales. En segundo lugar, se aborda el estudio de la ubicación de los estudios de comunicación en las primeras 40 universidades del ranking de Shangai. Para ello, se han estudiado los planes de estudio (grado y postgrado) y la disposición estructural de sus facultades tanto en el campo de la comunicación audiovisual como del periodismo. Los resultados demuestran que, frente a lo que comúnmente se da por sentado, nuestras titulaciones se suelen encontrar mucho más cerca de centros vinculados explícitamente con las “humanidades”. Del mismo modo, mostramos cómo el número de universidades que apuestan por la comunicación es notablemente alto (80% del núcleo del ránking). Finalmente, se debate la posibilidad de definir una nueva epistemología de las ciencias de la comunicación, que asuma su carácter interdisciplinar, esto es, como espacio disciplinar en el que concurren saberes humanísticos y de las ciencias sociales.
Survival outcomes of low-risk and intermediate-risk stage IB1 cervical cancer patients
Authors: Vanichtantikul Asama , Tantbirojn Patou , Manchana Tarinee 
Published: December 2019

Abstract

Background
Survival for patients with early stage cervical cancer without any high-risk factors treated with radical hysterectomy is excellent. However, there are few data on the survival outcomes for low-risk and intermediate-risk early stage cervical cancer patients.

Objective
To determine survival outcomes and prognostic factors of low-risk and intermediate-risk stage IB1 cervical cancer patients.

Methods
Stage IB1 cervical cancer patients with radical hysterectomy and pelvic lymphadenectomy were retrospectively reviewed. Patients with positive pelvic nodes, parametrial involvement, and positive margin who are classified as high-risk patients were excluded. Patients with squamous cell carcinoma or grade 1–2 adenocarcinoma, tumor size less than 2 cm, no lymphovascular space invasion (LVSI), and depth of stromal invasion (DSI) less than 10 mm were defined as low-risk patients. Survival was evaluated using the Kaplan–Meier method and compared by the log-rank test. Multivariate analysis was performed using Cox proportional-hazards regression.

Results
There were 82 (42.3%) low-risk patients and 112 (57.7%) intermediate-risk patients. More patients in intermediate risk received adjuvant treatment (3.6% and 14.3%, P = 0.07). Three (3.6%) low-risk patients and 18 (16.1%) intermediate-risk patients had recurrent disease (P = 0.004). At median follow-up of 86 months, 1.2% of low-risk patients and 8.9% of intermediate-risk had cancer-related deaths (P = 0.02). Low-risk patients had significantly better 5-year disease-free survival (98.2% vs 91.1%, P = 0.01) and estimated 5-year overall survival (98.5% vs 91.1%, P = 0.01). DSI more than 10 mm and presence of LVSI were significantly associated with recurrence. However, LVSI was an independent prognostic factor.

Conclusion
Stage IB1 cervical cancer patients had excellent survival. Low-risk patients had significantly better survival. Presence of LVSI was an independent prognostic factor.
Changes in protein patterns of Staphylococcus aureus and Escherichia coli by silver nanoparticles capped with poly (4-styrenesulfonic acid-co-maleic acid) polymer
Authors: Tamiyakul Hathaichanok , Roytrakul Sittiruk , Jaresitthikunchai Janthima , Phaonakrop Narumon , Tanasupawat Somboon , Warisnoicharoen Warangkana 
Published: December 2019

Abstract

Background
While silver nanoparticles (AgNPs) are increasingly attractive as an antibacterial agent in many applications, the effect of AgNPs on bacterial protein profiles, especially AgNPs stabilized by polymeric molecules, is not well understood.

Objectives
To investigate the changes in bacterial protein patterns by AgNPs capped with poly (4-styrenesulfonic acid-co-maleic acid) (AgNPs-PSSMA) polymer toward Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922.

Methods
The growth of bacteria after incubated with AgNPs-PSSMA for different time intervals was determined by optical density at 600 nm. Their protein patterns were observed using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and the proteomic analysis of extracted proteins was determined by liquid chromatography-tandem mass spectrometry (LC–MS/MS).

Results
AgNPs-PSSMA was able to inhibit the growth of both S. aureus and E. coli cells. The treated bacterial cells expressed more proteins than the untreated cells as seen from SDS-PAGE study. Nanosilver (NS) caused the upregulation of metabolic gene, waaA, in S. aureus cells. For E. coli cells, the upregulated proteins were metabolic genes (srlB, fliE, murD) and other genes dealt with DNA replication (dinG), DNA–RNA transcription (yrdD), RNA– protein translation (rplD), molecular transport (sapF), and signal transduction (tdcF).

Conclusions
The antibacterial effect of AgNPs-PSSMA may arise by changing the bacterial proteins and thus interfering with the normal cell function.
The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review
Authors: Rachmawati Sesty , Prihhastuti-Puspitasari Hanni , Zairina Elida 
Published: December 2019

Abstract

Background
The Chronic Disease Management Program or Program Pengelolaan Penyakit Kronis (Prolanis) is a program initiated by the Social Insurance Administration Organization or Badan Penyelenggara Jaminan Social (BPJS) in Indonesia. Prolanis aim to provide a proactive healthcare service approach for patients with chronic diseases particularly those with diabetes mellitus and hypertension. Prolanis also aims to achieve the optimal quality of life in patients with chronic disease through effective and efficient healthcare services including cost. All primary healthcare centers and a few of the private clinics in Indonesia have implemented Prolanis, however, the impact of the program has not been reviewed. This review aimed to see the implementation of Prolanis in healthcare facilities in Indonesia.

Methods
A literature review was conducted by searching articles through Google Scholar and PubMed databases up to August 2019. The following keywords or terms were used: Prolanis, BPJS indexed with terms related to blood pressure or hypertension in Indonesia. The references, citations and similar articles from the identified articles were used to identify additional sources.

Results
Twenty-four articles were identified through the first search using the key terms although only eight articles met the inclusion criteria. This review showed that the implementation of Prolanis in the healthcare facilities in Indonesia was varied in terms of the activities and services provided. The healthcare professional involved in the implementation of Prolanis were also varied. There were some barriers faced by the healthcare facilities including the availability of funding, the healthcare facilities and infrastructures, the unavailability of standard operating orocedures (SOPs) as well as the limitation of human resources involved in Prolanis.

Conclusions
The implementation of Prolanis in Indonesia has not been optimized, as there were some barriers during its implementation in the healthcare facilities.
What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature
Authors: Dunger David , Darendeliler Feyza , Kandemir Nurgun , Harris Mark , Rabbani Ali , Kappelgaard Anne-Marie 
Published: December 2019

Abstract

Background
An increasing body of evidence supports the view that both an adverse intrauterine milieu and rapid postnatal weight gain in children born small for gestational age (SGA) contribute towards the risk for the development of chronic diseases in adult life.

Content
The aim of this review was to identify and summarize the published evidence on metabolic and cardiovascular risk, as well as risk of impaired cardiac function, intellectual capacity, quality of life, pubertal development and bone strength among children born SGA. The review will then address whether growth hormone (GH) therapy, commonly prescribed to reduce the height deficit in children born SGA who do not catch up in height, increases or decreases these risks over time.

Summary
Overall, there are limited data in support of a modest beneficial effect of GH therapy on the adverse metabolic and cardiovascular risk observed in short children born SGA. Evidence to support a positive effect of GH on bone strength and psychosocial outcomes is less convincing.

Outlook
Further evaluation into the clinical relevance of any potential long-term benefits of GH therapy on metabolic and cardiovascular endpoints is warranted.
Maternal characteristics and pregnancy outcomes of women with chronic hypertension: a population-based study
Authors: Maducolil Mariam K. , Al-Obaidly Sawsan , Olukade Tawa , Salama Husam , AlQubaisi Mai , Al Rifai Hilal 
Published: December 2019

Abstract

Background
We aimed to study the maternal characteristics and obstetric and neonatal outcomes in pregnant mothers with chronic hypertension (CHTN) compared to non-CHTN.

Methods
The study was a population-based cohort study, and a PEARL-Peristat Study (PPS) for the year of 2017. There were 20,210 total births including 19,762 singleton and 448 multiple births. We excluded multiple gestations from the analysis as they differ in fetal growth, duration of gestation and have a higher rate of obstetric and neonatal complications. We compared the maternal characteristics of mothers with pre-existing HTN with non-hypertensive mothers and studied the obstetric and neonatal outcomes including cesarean section, stillbirths, prematurity, macrosomia and postpartum hemorrhage (PPH).

Results
We identified 223 births of mothers with essential HTN. The overall prevalence of CHTN in our population was 1.1% (223/20,210). In regard to maternal characteristics, women with CHTN were at or above 35 years of age at the time of delivery 58.9% compared to non-CHTN women 18.7%, P-value <0.001. Pre-existing diabetes was found more in women with CHTN 15.1% compared to non-CHTN women 1.9%, P-value <0.001; while obesity was found in 64% of women with CHTN compared to 32.5% in non-CHTN women, P-value <0.001. Preterm birth was noted in 26% compared to 8% in CHTN compared to non-CHTN women, respectively, P-value <0.001. The rate of stillbirth was similar between the two groups, 0.9% compared to 0.6% in CHTN compared to non-CHTN women, respectively, P-value 0.369.

Conclusion
Hypertensive mothers have multiple other comorbidities. When compared to the general population, they are older, parous, diabetic and obese with an increased risk of preterm birth and cesarean deliveries. Lifestyle modification, extensive pre-conceptional counseling and multidisciplinary antenatal care are required for such a high-risk group.
High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism
Authors: Descloux Adrien , Müller Marcel , Navikas Vytautas , Markwirth Andreas , van den Eynde Robin , Lukes Tomas , Hübner Wolfgang , Lasser Theo , Radenovic Aleksandra , Dedecker Peter , Huser Thomas 
Published: December 2019

Abstract
Super-resolution structured illumination microscopy (SR-SIM) can be conducted at video-rate acquisition speeds when combined with high-speed spatial light modulators and sCMOS cameras, rendering it particularly suitable for live-cell imaging. If, however, three-dimensional (3D) information is desired, the sequential acquisition of vertical image stacks employed by current setups significantly slows down the acquisition process. In this work, we present a multiplane approach to SR-SIM that overcomes this slowdown via the simultaneous acquisition of multiple object planes, employing a recently introduced multiplane image splitting prism combined with high-speed SIM illumination. This strategy requires only the introduction of a single optical element and the addition of a second camera to acquire a laterally highly resolved 3D image stack. We demonstrate the performance of multiplane SIM by applying this instrument to imaging the dynamics of mitochondria in living COS-7 cells.