bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Reading the Mind in the Eyes” in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study
Authors: Baltazar Matias , Geoffray Marie‐Maude , Chatham Christopher , Bouvard Manuel , Martinez Teruel Axelle , Monnet David , Scheid Isabelle , Murzi Eleonora , Couffin‐Cadiergues Sandrine , Umbricht Daniel , Murtagh Lorraine , Delorme Richard , Ly Le‐Moal Myriam , Leboyer Marion , Amestoy Anouck 
Published: September 2020

Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ > 70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD.Lay SummaryThe Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults.
Reduced Language Lateralization in Autism and the Broader Autism Phenotype as Assessed with Robust Individual‐Subjects Analyses
Authors: Jouravlev Olessia , Kell Alexander J.E. , Mineroff Zachary , Haskins Amanda J. , Ayyash Dima , Kanwisher Nancy , Fedorenko Evelina 
Published: September 2020

One of the few replicated functional brain differences between individuals with autism spectrum disorders (ASD) and neurotypical (NT) controls is reduced language lateralization. However, most prior reports relied on comparisons of group‐level activation maps or functional markers that had not been validated at the individual‐subject level, and/or used tasks that do not isolate language processing from other cognitive processes, complicating interpretation. Furthermore, few prior studies have examined functional responses in other brain networks, as needed to determine the spatial selectivity of the effect. Using functional magnetic resonance imaging (fMRI), we compared language lateralization between 28 adult ASD participants and carefully pairwise‐matched controls, with the language regions defined individually using a well‐validated language “localizer” task. Across two language comprehension paradigms, ASD participants showed less lateralized responses due to stronger right hemisphere activity. Furthermore, this effect did not stem from a ubiquitous reduction in lateralization of function across the brain: ASD participants did not differ from controls in the lateralization of two other large‐scale networks—the Theory of Mind network and the Multiple Demand network. Finally, in an exploratory study, we tested whether reduced language lateralization may also be present in NT individuals with high autism‐like traits. Indeed, autistic trait load in a large set of NT participants (n = 189) was associated with less lateralized language responses. These results suggest that reduced language lateralization is robustly associated with autism and, to some extent, with autism‐like traits in the general population, and this lateralization reduction appears to be restricted to the language system.Lay SummaryHow do brains of individuals with autism spectrum disorders (ASD) differ from those of neurotypical (NT) controls? One of the most consistently reported differences is the reduction of lateralization during language processing in individuals with ASD. However, most prior studies have used methods that made this finding difficult to interpret, and perhaps even artifactual. Using robust individual‐level markers of lateralization, we found that indeed, ASD individuals show reduced lateralization for language due to stronger right‐hemisphere activity. We further show that this reduction is not due to a general reduction of lateralization of function across the brain. Finally, we show that greater autistic trait load is associated with less lateralized language responses in the NT population. These results suggest that reduced language lateralization is robustly associated with autism and, to some extent, with autism‐like traits in the general population. Autism Res 2020, 13: 1746–1761. © 2020 International Society for Autism Research and Wiley Periodicals LLC
Prenatal diagnosis of Proteus syndrome: Diagnosis of an AKT1 mutation from amniocytes
Authors: Abell Katherine , Tolusso Leandra , Smith Nicki , Hopkin Robert , Vawter‐Lee Marissa , Habli Mounira , Riddle Stefanie , Calvo‐Garcia Maria A. , Guan Qiaoning , Bierbrauer Karin , Hwa Vivian , Saal Howard M. 
Published: September 2020

AbstractProteus syndrome is a mosaic genetic overgrowth disorder caused by a postzygotic, mosaic activating mutation in AKT1. Rare prenatal presentations include segmental tissue overgrowth, and skeletal and CNS anomalies. We present the first report of prenatally diagnosed and molecularly confirmed Proteus syndrome. Prenatal imaging identified megalencephaly, brain and eye malformations, focal soft tissue enlargement, and ambiguous genitalia. Exome sequencing performed on cultured amniocytes demonstrated an AKT1 pathogenic variant consistent with Proteus syndrome, and postnatal examination confirmed the diagnosis. Postnatal Sanger sequencing could not identify the AKT1 pathogenic variant. This case underscores the importance of prenatal exome sequencing on cultured amniocytes for mosaic overgrowth disorders, as well as provides additional information on the prenatal phenotype of Proteus syndrome, and highlights the impact of prenatal diagnosis on postnatal management.
A four‐gene signature associated with clinical features can better predict prognosis in prostate cancer
Authors: Yuan Penghui , Ling Le , Fan Qing , Gao Xintao , Sun Taotao , Miao Jianping , Yuan Xianglin , Liu Jihong , Liu Bo 
Published: September 2020

AbstractProstate cancer (PCa) is one of the most deadly urinary tumors in men globally, and the 5‐year over survival is poor due to metastasis of tumor. It is significant to explore potential biomarkers for early diagnosis and personalized therapy of PCa. In the present study, we performed an integrated analysis based on multiple microarrays in the Gene Expression Omnibus (GEO) dataset and obtained differentially expressed genes (DEGs) between 510 PCa and 259 benign issues. The weighted correlation network analysis indicated that prognostic profile was the most relevant to DEGs. Then, univariate and multivariate COX regression analyses were conducted and four prognostic genes were obtained to establish a four‐gene prognostic model. And the predictive effect and expression profiles of the four genes were well validated in another GEO dataset, The Cancer Genome Atlas and the Human Protein Atlas datasets. Furthermore, combination of four‐gene model and clinical features was analyzed systematically to guide the prognosis of patients with PCa to a largest extent. In summary, our findings indicate that four genes had important prognostic significance in PCa and combination of four‐gene model and clinical features could achieve a better prediction to guide the prognosis of patients with PCa.
Advice seeking and loaning of money related to relapse in recovery homes
Authors: Jason Leonard A. , Guerrero Mayra , Salomon‐Amend Meghan , Lynch Gabrielle , Stevens Ed , Light John M. , Stoolmiller Mike 
Published: September 2020

AbstractRecovery homes help individuals who have completed substance use treatment programs re‐integrate back into the community. However, it is unclear what factors determine who will succeed in these settings and how these factors may be reinforced or undermined by the social interactions and social networks between residents living in the Oxford House recovery homes. In an effort to better understand these factors, the current study evaluated (a) the extent to which the density of social networks (i.e., friendship, willingness to loan money, and advice‐seeking relationships) is associated with social capital (i.e., sense of community, quality of life, hopefulness, self‐efficacy), and (b) whether the density of social networks predicts relapse over time. Among the findings, willingness to loan money was positively associated with all four individual‐level social capital variables, suggesting that availability of instrumental resources may be important to ongoing recovery. To test whether these house‐level social network factors then support recovery, a survival analysis was conducted, finding associations between relapse risk and the network densities over a 28‐month span. In particular, more dense advice‐seeking networks were associated with higher rates of relapse, suggesting that the advice‐seeking might represent a sign of organisational house problems, with many residents unsure of issues related to their recovery. In contrast, more dense loaning networks were associated with less relapse, so willingness to lend money could be measuring a willingness to help those in need. The implications of these findings are discussed.
Counterfeit luxury consumption: A review and research agenda
Authors: Khan Sameeullah , Fazili Asif Iqbal , Bashir Irfan 
Published: September 2020

AbstractThis article captures the present state of research on counterfeit luxury consumption by providing a critical review of the existing body of knowledge. The article proposes a novel conceptualization of counterfeit luxury consumption from a consumer perspective. Based on predetermined inclusion criteria, the paper provides a systematic review of the growing yet still fragmented scholarship on counterfeit luxury consumption. It provides a historical overview of the extant counterfeiting research, synthesizes the existing body of knowledge, and provides propositions for future research and practice. In our pursuit towards building a robust counterfeiting theory, this study identifies the key perspectives that seek to explain the consumption of counterfeit luxury brands through different lenses. The article reviews key theories and constructs, identifies inconsistencies in findings, and provides explanations towards a common understanding. To this pursuit, a synthesis of three counterfeiting research domains is presented; moreover, an integrated model, which captures their interrelationships, is proposed. Finally, the implications for theory and practice are spelled out. The resultant five key tenets are, therefore, proposed to guide the future of research in counterfeit luxury consumption.
Antibacterial Triketone‐Phloroglucinol‐Triketone Adducts fromMyrtus communis
Authors: Wu Yan , Liu Jiao‐Wen , Liu Chao , Huang Xiao‐Jun , Li Ni‐Ping , Ye Wen‐Cai , Wang Lei 
Published: September 2020

AbstractMyrtucyclitones A–C ((+)‐ and (−)‐1–3), three pairs of new triketone‐phloroglucinol‐triketone hybrids were isolated from the plantMyrtus communis. Their structures with absolute configurations were established by NMR analysis and chemical calculations. Myrtucyclitones B and C exhibited remarkable antibacterial effect.
Bioorthogonal Reactions in Animals
Authors: Porte Karine , Riberaud Maxime , Châtre Rémi , Audisio Davide , Papot Sébastien , Taran Frédéric 
Published: September 2020

AbstractThe advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications. In particular, these tools have made it possible to achieve what is considered to be the holy grail of many researchers involved in chemical biology: to perform unnatural chemical reactions within living organisms. In this minireview, we present an update of bioorthogonal reactions that have been carried out in animals for various applications. We outline the advances made in the understanding of fundamental biological processes, and the development of innovative imaging and therapeutic strategies using bioorthogonal chemistry.
The final nail in the coffin for immediate catheterization for refractory cardiac arrest with ongoing chest compressions
Authors: Mercado Nestor , Blankenship James C. 
Published: September 2020

Key Points
In a cohort of 219 patients with out of hospital cardiac arrest, survival correlated with age, initial shockable rhythm, recovery of spontaneous circulation (ROSC) before starting catheterization, and initial pH.
Mortality was 98% in patients who underwent catheterization before ROSC.
Early studies of emergency extra‐corporeal membrane oxygenation life support combined with hypothermia, and coronary intervention, suggest this “hyper‐invasive” strategy may offer significant improvement in outcomes compared to conventional strategies employed in this study.
Gender disparities in high‐risk angioplasty: Still room for improvement
Authors: Belardi Jorge A. , Lamelas Pablo M. 
Published: September 2020

Key Points
The use of complex medical interventions is frequently underutilized in females.
Female patients undergoing high‐risk angioplasty with ventricular support represent a higher risk subgroup but experienced similar clinical events.
Although promising, these findings still suggest room for improvement in gender disparities related to advanced medical interventions utilization.
Metastatic angiosarcoma of unknown primary site misdiagnosed as tuberculosis
Authors: Issakwisa Mwakyula , Mwakyusa Ngwilo , Torres Liset , Ngatunga Cecilia , Chaula Baraka , Maro Haika , Mboma Lazaro , Nguma Irene , Nqwata Lamla , Mujwahuzi Leodegard 
Published: September 2020

AbstractTuberculosis in endemic areas is likely to be overdiagnosed in patients with atypical clinical and imaging findings mimicking tuberculosis, as in our case of angiosarcoma. Detailed history, physical examination, imaging, and histopathology avert diagnosis of tumors as tuberculosis in resource‐limited settings, where countless diseases have common clinical and imaging presentations.
Pyrene‐Terminated Tin Sulfide Clusters: Optical Properties and Deposition on a Metal Surface
Authors: Geringer Eugenie , Gerhard Marina , Koch M. , Krug Claudio K. , Gottfried J. Michael , Dehnen Stefanie 
Published: September 2020

AbstractHerein, we present the synthesis of two pyrene‐functionalized clusters, [(RpyrSn)4S6]⋅2 CH2Cl2 (4) and [(RpyrSn)4Sn2S10]⋅n CH2Cl2 (n=4, 5 a; n=2, 5 b; Rpyr=CMe2CH2C(Me)N‐NC(H)C16H9), both of which form in reactions of the organotin sulfide cluster [(RNSn)4S6] (C; RN=CMe2CH2C(Me)N‐NH2) with the well‐known fluorescent dye 1‐pyrenecarboxaldehyde (B). In contrast, reactions using an organotin sulfide cluster with another core structure, [(RNSn)3S4Cl] (A), leads to formation of small molecular fragments, [(RpyrCl2Sn)2S] (1), (pyren‐1‐ylmethylene)hydrazine (2), and 1,2‐bis(pyren‐1‐ylmethylene)hydrazine (3). Besides synthesis and structures of the new compounds, we report the influence of the inorganic core on the optical properties of the dye, which was analyzed exemplarily for compound 5 a via absorption and fluorescence spectroscopy. This cluster was also used for exploring the potential of such non‐volatile clusters for deposition on a metal surface under vacuum conditions.
Development of latent fingerprints on different surface materials by candle soot coating
Authors: Jonas Albert , Oetken Marco 
Published: September 2020

AbstractDie Möglichkeit latente Fingerabdrücke mithilfe von Kerzenrußabscheidung zu visualisieren, wird mit Blick auf die Schule vorgestellt. Das Verfahren ermöglicht Fingerabdrücke auf verschiedenen Oberflächen (Glas, Keramik, Metall, Papier) schnell und gefahrlos zu entwickeln, wobei die entwickelten Positivabdrücke sehr kontrastreich sind. Die Grundlage der Methode liegt in der unterschiedlich starken Adhäsion von Rußpartikeln auf den Rückständen des Fingerabdrucks und dem Spurenträgermaterial. Im Kontext der Forensik bildet der Versuch einen motivierenden Einstieg in die Thematik um Van‐der‐Waals‐Wechselwirkungen.
Risk stratification and clinical outcome in the atypia of undetermined significance category in the Milan System for Reporting Salivary Gland Cytopathology
Authors: Wangsiricharoen Sintawat , Maleki Zahra 
Published: September 2020

BackgroundAtypia of undetermined significance (AUS) is a category of the Milan System for Reporting Salivary Gland Cytopathology that refers to salivary gland fine‐needle aspiration (FNA) specimens that cannot be definitively diagnosed as neoplastic or nonneoplastic.MethodsThe AUS FNA samples were selected from a large academic institution from 2008 through 2018. The AUS cases were divided into 6 subgroups. The risk of malignancy (ROM), risk of neoplasm (RON), and clinical outcomes for each subgroup were evaluated.ResultsA total of 123 cases were found (76 males and 47 females with a mean age of 62 years [range, 6‐94 years]). The parotid gland was the most common FNA site (103 cases), followed by the submandibular gland (9 cases). The overall RON and ROM were 63% and 47%, respectively. Among the subgroups, salivary gland lymph nodes or lymphoid lesions was the most common diagnosis (42%), whereas mucinous cystic lesions with no or a scant epithelial component was the least common (2%). The specimens with preparation artifacts category had the highest RON and ROM (100% for both), whereas the reactive and reparative atypia indefinite for a neoplasm category had the lowest RON and ROM (7% for both). The salivary gland lymph nodes or lymphoid lesions indefinite for a lymphoproliferative disorder category had the second highest RON and ROM at 77% and 74%, respectively.ConclusionsThe overall RON and ROM for the AUS category were 63% and 47%, respectively. The RON and ROM varied among the different AUS subgroups, being highest in the specimens with preparation artifacts category and lowest in the reactive and reparative atypia category, thereby demonstrating the importance of subgrouping in the AUS specimens.
Sympathetic innervation of inguinal white adipose tissue in the mouse
Authors: Huesing Clara , Qualls‐Creekmore Emily , Lee Nathan , François Marie , Torres Hayden , Zhang Rui , Burk David H. , Yu Sangho , Morrison Christopher D. , Berthoud Hans‐Rudolf , Neuhuber Winfried , Münzberg Heike 
Published: September 2020

AbstractAdipose tissue plays an important role in metabolic homeostasis and its prominent role as endocrine organ is now well recognized. Adipose tissue is controlled via the sympathetic nervous system (SNS). New viral, molecular‐genetic tools will soon allow a more detailed study of adipose tissue innervation in metabolic function, yet, the precise anatomical extent of preganglionic and postganglionic inputs to the inguinal white adipose tissue (iWAT) is limited. Furthermore, several viral, molecular‐genetic tools will require the use of cre/loxP mouse models, while the available studies on sympathetic iWAT innervation were established in larger species. In this study, we generated a detailed map for the sympathetic innervation of iWAT in male and female mice. We adapted iDISCO tissue clearing to process large, whole‐body specimens for an unprecedented view of the natural abdominal SNS. Combined with pseudorabies virus retrograde tracing from the iWAT, we defined the preganglionic and postganglionic sympathetic input to iWAT. We used fluorescence‐guided anatomical dissections of sympathetic nerves in reporter mice to further clarify that postganglionic axons connect to iWAT via lateral cutaneous rami (dorsolumbar iWAT portion) and the lumbar plexus (inguinal iWAT portion). Importantly, these rami carry axons that branch to iWAT, as well as axons that travel further to innervate the skin and vasculature, and their functional impact will require consideration in denervation studies. Our study may serve as a comprehensive map for future experiments that employ virally driven neuromodulation techniques to predict anatomy‐based viral labeling.
Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet
Authors: Gueneau de Mussy Pierre , Sidharta Patricia N. , Wuerzner Gregoire , Maillard Marc P. , Guérard Nicolas , Iglarz Marc , Flamion Bruno , Dingemanse Jasper , Burnier Michel 
Published: September 2020

Aprocitentan is a novel, oral, dual endothelin receptor antagonist (ERA) in development in difficult‐to‐control hypertension. As fluid retention and edema are concerns with ERAs, we investigated whether aprocitentan causes weight gain in healthy subjects on a high sodium diet and explored potential mechanisms if occurring. This double‐blind, randomized, placebo‐controlled, crossover study enrolled 28 subjects. Three doses of aprocitentan (10, 25, or 50 mg/day for 9 days) were compared with placebo. Increases in body weight were observed with aprocitentan (placebo‐corrected mean weight gains [90% confidence interval]) of 0.43 [0.05–0.80], 0.77 [0.03–1.51], and 0.83 [0.33–1.32] kg at 10 mg, 25 mg, and 50 mg, respectively. Decreases in hemoglobin and uric acid were observed. Plasma volume increased at most by 5.5% without dose‐response relationship. Urinary sodium excretion decreased at 10 mg and 25 mg but not at 50 mg. Therefore, aprocitentan produced moderate weight increases in healthy subjects on high sodium diet, without obvious sodium retention.