bluuebunny/crossref_metadata_2025_split huggingface dataset:
40th Annual David W Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2019 Annual Meeting
Authors: Braddock Stephen R. , Lipinski Robert J. , Carey John C. 
Published: March 2020

AbstractThe 40th Annual David W. Smith Workshop on Malformations and Morphogenesis occurred August 23rd ‐28th, 2019 at the Snowbird Resort in Snowbird, Utah. The Workshop, which honors the legacy of David W. Smith, brought together clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis from around the world. In addition to mechanisms of morphogenesis and delineation of new syndromes, the Workshop highlighted five themes: deformations, disruptions and fetal dysmorphology; orofacial clefting; central nervous system malformations; ciliopathies; and X‐linked intellectual disabilities. This Conference Report includes the abstracts presented at the 2019 Workshop.
Haploinsufficiency of the basic helix–loop–helix transcription factorHAND2causes congenital heart defects
Authors: Cohen Ana S. A. , Simotas Christopher , Webb Bryn D. , Shi Huanzhi , Khan Wahab A. , Edelmann Lisa , Scott Stuart A. , Singh Ram 
Published: March 2020

AbstractCongenital heart defects (CHDs) are caused by a disruption in heart morphogenesis, which is dependent, in part, on a network of transcription factors (TFs) that regulate myocardial development. Heterozygous sequence variants in the basic helix–loop–helix TF gene heart and neural crest derivatives expressed 2 (HAND2)have been reported among some patients with CHDs; however,HAND2has not yet been established as a Mendelian disease gene. We report a 31‐month‐old male with unicommissural unicuspid aortic valve, moderate aortic stenosis, and mild pulmonic stenosis. Chromosome analysis revealed a normal 46,XY karyotype, and a CHD sequencing panel was negative for pathogenic variants inNKX2.5,GATA4,TBX5, andCHD7. However, chromosomal microarray (CMA) testing identified a heterozygous 546.0‐kb deletion on chromosome 4q34.1 (174364195_174910239[GRCh37/hg19]) that included exons 1 and 2 ofSCRG1,HAND2, andHAND2‐AS1. Familial CMA testing determined that the deletion was paternally inherited, which supported a likely pathogenic classification as the proband's father had previously undergone surgery for Tetralogy of Fallot. The family history was also notable for a paternal uncle who had previously died from complications related to an unknown heart defect. Taken together, this first report of aHAND2andHAND2‐AS1deletion in a family with CHDs strongly supports haploinsufficiency ofHAND2as an autosomal dominant cause of CHD.
Visible Light and Molecular Iodine‐Mediated Diastereoselective Intermolecular Lactonization of Styrenes with Carbonyls
Authors: Oe Karin , Goto Mayuki , Maejima Saki , Yamaguchi Eiji , Itoh Akichika 
Published: March 2020

Abstractγ‐Lactones and their derivatives show diverse biological activities, and lactone skeletons are found in various naturally occurring products, pharmaceuticals, and agrochemicals. Although there are hundreds of methodologies for synthesizing γ‐lactone, the methods that are straightforward, environmentally friendly, and stereoselective are almost unknown. In this study, the molecular iodine/visible light‐mediated highly cis‐diastereoselective lactonization reaction of styrenes with Meldrum's acid was achieved. The developed reaction proceeded with the formation of a C−C bond at the olefin's β‐position and a C−O bond at its α‐position via a single‐step reaction with high diastereoselectivity and moderate‐to‐good yield.
Titanium Doping to Enhance Thermoelectric Performance of 19‐Electron VCoSb Half‐Heusler Compounds with Vanadium Vacancies
Authors: Li Shan , Bai Fengxian , Wang Ruifang , Chen Chen , Li Xiaofang , Cao Feng , Yu Bo , Sui Jiehe , Liu Xingjun , Ren Zhifeng , Zhang Qian 
Published: March 2020

AbstractThe 19‐electron VCoSb compounds are actually composites of an off‐stoichiometric half‐Heusler phase and impurities. Here the compositional adjustment is systematically studied in V1−xCoSb to obtain single‐phase V0.955CoSb. Hall measurements suggest that such a V vacancy, as well as Ti doping, can optimize the carrier concentration, which decreases from ≈11.3 × 1021 cm−3 for VCoSb to ≈6.3 × 1021 cm−3 for V0.755Ti0.2CoSb. Low sound velocity contributes to the intrinsically low lattice thermal conductivity for VCoSb‐based materials. The high Ti‐dopant content results in enhanced point‐defect scattering, which further decreases the lattice thermal conductivity. Finally, the optimized n‐type V0.855Ti0.1CoSb is found to reach a peak ZT of ≈0.7 at 973 K. The work demonstrates that the VCoSb‐based half‐Heuslers are promising thermoelectric materials.
Two‐Dimensional Perovskite Oxynitride K2LaTa2O6N with an H+/K+ Exchangeability in Aqueous Solution Forming a Stable Photocatalyst for Visible‐Light H2 Evolution
Authors: Oshima Takayoshi , Ichibha Tom , Oqmhula Kenji , Hibino Keisuke , Mogi Hiroto , Yamashita Shunsuke , Fujii Kotaro , Miseki Yugo , Hongo Kenta , Lu Daling , Maezono Ryo , Sayama Kazuhiro , Yashima Masatomo , Kimoto Koji , Kato Hideki , Kakihana Masato , Kageyama Hiroshi , Maeda Kazuhiko 
Published: March 2020

AbstractUndoped layered oxynitrides have not been considered as promising H2‐evolution photocatalysts because of the low chemical stability of oxynitrides in aqueous solution. Here, we demonstrate the synthesis of a new layered perovskite oxynitride, K2LaTa2O6N, as an exceptional example of a water‐tolerant photocatalyst for H2 evolution under visible light. The material underwent in‐situ H+/K+ exchange in aqueous solution while keeping its visible‐light‐absorption capability. Protonated K2LaTa2O6N, modified with an Ir cocatalyst, exhibited excellent catalytic activity toward H2 evolution in the presence of I− as an electron donor and under visible light; the activity was six times higher than Pt/ZrO2/TaON, one of the best‐performing oxynitride photocatalysts for H2 evolution. Overall water splitting was also achieved using the Ir‐loaded, protonated K2LaTa2O6N in combination with Cs‐modified Pt/WO3 as an O2 evolution photocatalyst in the presence of an I3−/I− shuttle redox couple.
Sulfonated Microporous Polymer Membranes with Fast and Selective Ion Transport for Electrochemical Energy Conversion and Storage
Authors: Zuo Peipei , Li Yuanyuan , Wang Anqi , Tan Rui , Liu Yahua , Liang Xian , Sheng Fangmeng , Tang Gonggen , Ge Liang , Wu Liang , Song Qilei , McKeown Neil B. , Yang Zhengjin , Xu Tongwen 
Published: March 2020

AbstractMembranes which allow fast and selective transport of protons and cations are required for a wide range of electrochemical energy conversion and storage devices, such as proton‐exchange membrane (PEM) fuel cells (PEMFCs) and redox flow batteries (RFBs). Herein we report a new approach to designing solution‐processable ion‐selective polymer membranes with both intrinsic microporosity and ion‐conductive functionality. Polymers are synthesized with rigid and contorted backbones, which incorporate hydrophobic fluorinated and hydrophilic sulfonic acid functional groups, to produce membranes with negatively charged subnanometer‐sized confined ionic channels. The ready transport of protons and cations through these membranes, and the high selectivity towards nanometer‐sized redox‐active molecules, enable efficient and stable operation of an aqueous alkaline quinone redox flow battery and a hydrogen PEM fuel cell.
Design of Turn‐On Near‐Infrared Fluorescent Probes for Highly Sensitive and Selective Monitoring of Biopolymers
Authors: Ducharme Gerard T. , LaCasse Zane , Sheth Tanya , Nesterova Irina V. , Nesterov Evgueni E. 
Published: March 2020

AbstractSimple, sensitive, and selective detection of specific biopolymers is critical in a broad range of biomedical and technological areas. We present a design of turn‐on near‐infrared (NIR) fluorescent probes with intrinsically high signal‐to‐background ratio. The fluorescent signal generation mechanism is based on the aggregation/de‐aggregation of phthalocyanine chromophores controlled by selective binding of small‐molecule “anchor” groups to a specific binding site of a target biopolymer. As a proof‐of‐concept, we demonstrate a design of a sensor for EGFR tyrosine kinase—an important target in cancer research. The universality of the fluorescent signal generation mechanism, as well as the dependence of the response selectivity on the choice of the small‐molecule “anchor” group, make it possible to use this approach to design reliable turn‐on NIR fluorescent sensors for detecting specific protein targets present in the low‐nanomolar concentration range.
Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging
Authors: Huang Jiaguo , Pu Kanyi 
Published: March 2020

AbstractOptical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650–900 nm, conventional optical imaging often has a poor signal‐to‐background ratio and shallow penetration depth, which limits its ability in deep‐tissue in vivo imaging. Second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near‐infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep‐tissue imaging are also discussed.
Investigation of improved dielectric and thermal properties of ternary nanocomposite PMMA/MXene/ZnO fabricated by in‐situ bulk polymerization
Authors: Ul Haq Yasir , Murtaza Imran , Mazhar Sadaf , Ahmad Naeem , Qarni Awais A. , Ul Haq Zeeshan , Khan Shahid A. , Iqbal Mahmood 
Published: March 2020

AbstractElectric power system applications demand for high‐temperature dielectric materials. The improved performance of polymer nanocomposites requires improvement in their thermal conductivity & stability, dielectric stability and processing technique. However, they often lose their dielectric properties with a rise in temperature. Here, we offer a solution by incorporating electrically conducting material (MXene) and semiconducting inorganic nanoparticles (ZnO NPs) into an insulating PMMA polymer matrix to maintain high dielectric constant, both at the room and high temperature. Therefore, to achieve desirable thermal and dielectric properties is the main objective of the present study based on the homogeneous distribution of the nanofillers by in‐situ bulk polymerization assisted by strong sonication in the corresponding polymer. The introduction of MXene and ZnO NPs into the PMMA not only acquires a substantial increment in the dielectric constant, to attain a value 437, with minimum energy loss of 0.36 at 25 Hz, but also improves the thermal conductivity of PMMA up to 14 times by causing the reduction of thermal resistance, which is actually responsible for the poor thermal conductivity of amorphous pure PMMA polymer. More importantly, hybrid PMMA/4:2 wt% MXene:ZnO nanocomposite leads to an excellent thermal stability. Moreover, further characterization of the synthesized nanocomposites by FTIR, SEM and XRD leads to the evaluation of strong interaction of ternary components with PMMA matrix.
Cover Image, Volume 14, Issue 2
Authors: Zhang Jingzhi , Cai Di , Qin Yanlin , Liu Dehua , Zhao Xuebing 
Published: March 2020

The cover image is based on the Review Article High value‐added monomer chemicals and functional bio‐based materials derived from polymeric components of lignocellulose by organosolv fractionation by Xuebing Zhao et al., https://doi.org/10.1002/bbb.2057.
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A sensitive liquid chromatography–tandem mass spectrometry method for quantitative bioanalysis of fingolimod in human blood: Application to pharmacokinetic study
Authors: Gopinath R. , Narenderan S. T. , Kumar M. , Babu B. 
Published: March 2020

AbstractA simple and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the determination of fingolimod in human blood. The analyte and internal standard fingolimod‐d4 were extracted from 300 μl of human blood using protein precipitation coupled with solid‐phase extraction method. The chromatographic separation was achieved with a Kinetex biphenyl column (100 × 4.6 mm, 2.6 μm) under isocratic conditions at the flow rate of 0.8 ml/min and column temperature was maintained at 45°C. The detection of analyte and internal standard was carried out by tandem mass spectrometry, operated in positive ion and multiple reaction monitoring acquisition mode. The method was fully validated for its selectivity, precision, accuracy, linearity, stability, detection and quantification limit. The extraction recovery of fingolimod in human blood ranged from 98.39 to 99.54%. The developed method was linear over the concentration range of 5–2500 pg/ml with a detection limit of 1 pg/ml. The developed method was validated and successfully applied for pharmacokinetic study after oral administration of fingolimod capsules.
The role of metamemory on cognitive complaints in cancer patients
Authors: Giffard Bénédicte , Perrotin Audrey , Allain Philippe , Dayan Jacques , Eustache Francis , Grellard Jean‐Michel , Faveyrial Audrey , Joly Florence , Lange Marie 
Published: March 2020

AbstractObjectiveAlthough cancer patients frequently report cognitive disturbances, it is commonly asserted a lack of association between cognitive complaints and neuropsychological test performances. Our goal was to better understand the relationships between subjective and objective cognitive scores through a metamemory monitoring assessment.MethodsSixty cancer patients currently treated by chemotherapy and/or targeted therapy, and 30 healthy controls (HC) were included. Cognitive complaint was assessed by FACT‐cog, QAM and DEX questionnaires. One or more z‐scores ≤−1.65 among these three questionnaires defined the presence of cognitive complaints. Objective cognitive performances assessed episodic memory, processing speed and executive functions/working memory (ESR paradigm, TMT, Stroop, n‐back). Metamemory was assessed with a Judgment of Learning (JOL) task.ResultsPatients with cognitive complaints had significantly more depressive and anxiety symptoms (ps < .004), and lower performances on several cognitive tests (ps < .05) than both patients without complaints and HC. More specifically, analyses of the metamemory scores revealed that HC gave significantly more overestimations (“Yes” judgment and incorrect recall) than patients with cognitive complaints (p = .036). For these patients, JOL scores correlated positively with executive functioning (ps < .01).ConclusionMetamemory monitoring seems to be well‐preserved during cancer. What is more, patients make less overestimation than HC, and they do not underestimate their memory. An accurate self‐estimation of memory abilities in cancer patients, particularly those with mild cognitive deficits, may play an adaptive function. Our results suggest that the discrepancy frequently reported between cognitive complaints and objective cognitive scores may not be related to metamemory monitoring dysfunction.
Construction of integrated cloud computing platform for Japanese autonomous learning and examination
Authors: Sun Suping 
Published: March 2020

AbstractRegarding autonomous learning, Japan is no special case which characterizes the advancement of Japan's selection tests and school educational plan—especially since World War II—is a particularly focussed spotlight on names, dates, certainties, and figures as opposed to the verbal correspondence of ideas. However, for a couple of excellent establishments, both secondary schools and colleges strenuously stay away from test addresses that approach understudies to develop a composed reaction or even to peruse a section of a huge length. This disregard of the composed word would be inconceivable in social orders like China, Korea, and Vietnam, with their long custom of composing common administration assessments based on the Confucian classics. In this paper, Fuzzy reinforcement Oracle Database Algorithm has been used for changing the information on the board and organization. However, empowering the autonomous database is basic to our prosperity. the autonomous database learning subscription is an all‐computerized learning arrangement which is perfect for cloud directors, cloud engineers, and business experts, who need to get familiar with an autonomous database. This cloud learning subscription shows how the arrangement of a cloud based autonomous database cloud is appropriate for the remaining tasks at hand and a necessity. This is an extraordinary beginning stage for any individual who needs to find out about the main autonomous database in the market.
Expression profiles of miRNAs in giant cell tumor of bone showed miR‐187‐5p and miR‐1323 can regulate biological functions through inhibiting FRS2
Authors: Jin Yuanhan , Zhang Jing , Zhu Hao , Fan Gentao , Zhou Guangxin 
Published: March 2020

AbstractBackgroundGiant cell tumor of bone (GCTB) is considered to be a kind of borderline tumor, which has a tendency to recur and translocate. MicroRNAs are one type of small noncoding RNA, which can inhibit the translation of targeted mRNA through RNA‐induced silencing complex.MethodsMicroarray was conducted on three groups of tumor tissues and normal tissues from patients with GCTB, and results showed different expression profiles of miRNAs with Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes analysis. The functions of miR‐187‐5p and miR‐1323, which were highly expressed in GCTB, were examined by 5‐ethynyl‐2′‐deoxyuridine (EDU), transwell, and CCK8 assays. RNAhybrid et al. (RNA prediction softwares) predicted that the two microRNAs targeted fibroblast growth factor receptor substrate 2 (FRS2), which was verified by luciferase assay and rescue experiments.ResultsmiR‐187‐5p and miR‐1323 were highly expressed in tumor tissues. They can jointly regulate the biological functions of GCTB in vitro. Luciferase assay confirmed that the two microRNAs can bind to the 3′ untranslated regions (UTR) of mRNA of FRS2. And, rescue experiments verified the relationships between the two microRNAs and FRS2.ConclusionThere were some different‐expressed microRNAs between GCTB and normal tissues. miR‐187‐5p and miR‐1323 can regulate the biological functions of GCTB through influencing the expression of FRS2.
Sticking to common values: Neighbourhood social cohesion moderates the effect of value congruence on life satisfaction
Authors: Ponizovskiy Vladimir , Arant Regina , Larsen Mandi , Boehnke Klaus 
Published: March 2020

AbstractThis article aims to explicate the role of social cohesion in the relationship between adherence to common values and life satisfaction. Shared values are often assumed to be a constitutive element of social cohesion and are used in measurement of the concept. However, sociopsychological theory of values sees social cohesion rather as a moderator of the link between value congruence and life satisfaction, not as a constituent of value congruence. Based on a representative survey of the city of Bremen, Germany (N = 2605), we predict life satisfaction from person‐group value congruence and neighbourhood social cohesion. We find no relationship between value congruence and social cohesion, but a significant positive moderating effect of social cohesion on the relationship between value congruence and life satisfaction. The findings suggest that sticking to common values does not increase social cohesion, but that positive effects of value congruence are more pronounced in high‐cohesion neighbourhoods.
Design and Synthesis of Novel Arylisoxazole‐Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease
Authors: Saeedi Mina , Rastegari Arezoo , Hariri Roshanak , Mirfazli Seyedeh Sara , Mahdavi Mohammad , Edraki Najmeh , Firuzi Omidreza , Akbarzadeh Tahmineh 
Published: March 2020

AbstractA novel series of hybrid arylisoxazole‐chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5‐(3‐nitrophenyl)‐N‐{4‐[(2‐oxo‐2H‐1‐benzopyran‐7‐yl)oxy]phenyl}‐1,2‐oxazole‐3‐carboxamide depicted the most acetylcholinesterase (AChE) inhibitory activity (IC50=1.23 μm) and 5‐(3‐chlorophenyl)‐N‐{4‐[(2‐oxo‐2H‐1‐benzopyran‐7‐yl)oxy]phenyl}‐1,2‐oxazole‐3‐carboxamide was found to be the most potent butyrylcholinesterase (BChE) inhibitor (IC50=9.71 μm). 5‐(3‐Nitrophenyl)‐N‐{4‐[(2‐oxo‐2H‐1‐benzopyran‐7‐yl)oxy]phenyl}‐1,2‐oxazole‐3‐carboxamide was further investigated for its BACE1 inhibitory activity as well as neuroprotectivity and metal chelating ability as important factors involved in onset and progress of Alzheimer's disease. It could inhibit BACE1 by 48.46 % at 50 μm. It also showed 6.4 % protection at 25 μm and satisfactory chelating ability toward Zn2+, Fe2+, and Cu2+ ions. Docking studies of 5‐(3‐nitrophenyl)‐N‐{4‐[(2‐oxo‐2H‐1‐benzopyran‐7‐yl)oxy]phenyl}‐1,2‐oxazole‐3‐carboxamide and 5‐(3‐chlorophenyl)‐N‐{4‐[(2‐oxo‐2H‐1‐benzopyran‐7‐yl)oxy]phenyl}‐1,2‐oxazole‐3‐carboxamide confirmed desired interactions with those amino acid residues of the AChE and BChE, respectively.
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway
Authors: Zhu Liying , Dai Longguang , Yang Nenghong , Liu Mi , Ma Shuang , Li Chengcheng , Shen Jie , Lin Tao , Wang Dan , Pan Wei , Li Xing 
Published: March 2020

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most frequent cause of cancer‐related death. The IRX5 transcription factor plays a different role in multiple cancers and contributes to the development of many tumours. However, little is known about the molecular mechanisms of IRX5 in HCC. In this study, we found that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the expression of cyclin D1 and knockdown of IRX5 suppressed tumorigenicity in vivo. Furthermore, knockdown of IRX5 increased p53 and Bax expression and decreased Bcl‐2 expression. Thus, IRX5 suppressed apoptosis in HCC cells by inhibiting the p53 signalling pathway, indicating its role as a treatment target for HCC.Significance of the studyOur study demonstrated that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the expression of cyclin D1, and knockdown of IRX5 suppressed tumorigenicity in vivo. Furthermore, knockdown of IRX5 increased p53 and Bax expression and decreased Bcl‐2 expression. IRX5 suppressed apoptosis in HCC cells by inhibiting the p53 signalling pathway, indicating its role as a treatment target for HCC.