bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient method to investigate the equivalent series resistance of a capacitor in low frequency range
Authors: Zhang Hanlu , Huang Qiongdan , Wang Honggang , Shi Xinke 
Published: January 2020

The equivalent series resistance (ESR) is an important parameter for determining the quality of a capacitor. In general, the value of the ESR can be obtained only at a single frequency point during mass production testing, because obtaining the whole ESR curve by means of scanning the frequency range is time consuming. We present a novel method to investigate how the ESR varies with frequency during batch testing. We use the multi‐frequency synthesis excitation waveform to obtain the ESR at multiple frequency points. This allows the entire ESR curve to be obtained during one measurement period, thus greatly improving the measurement speed. The mathematical principle, the circuit realisation and the signal processing algorithm are discussed. Furthermore, a principle verification test is conducted, and the ESR values at seven frequency points are synchronously measured. The obtained results are consistent with those acquired from a standard LCR meter, and the entire measurement is completed within 10 ms, which confirms that our method is efficient and suitable for measurements in the mass production testing.
22q11.2 Microduplications: Two Clinical Reports Compared with Similar Cases from the Literature
Authors: Oyetunji Aderonke , Butler Merlin G. 
Published: January 2020

AbstractWe present two male subjects (6 and 14 years old) with mild dysmorphism, intellectual disability, and/or autism spectrum disorder with chromosome 22q11.2 microduplications of different sizes. We then compared the clinical and genetic findings with similar cases from the literature sharing the same 22q11.2 duplications. These rare duplications in our subjects were identified by high-resolution chromosomal microarray analysis and flanked by low copy repeats in the 22q11.2 region, specifically LCR22A, LCR22B, and LCR22D. The typical 22q11.2 defect generally involves a deletion at breakpoints LCR22A and LCR22D causing DiGeorge or velo-cardio-facial syndrome and not duplications of varying sizes as seen in our male subjects.
The Role of Interventional Radiology in the Management of Pancreatic Pathologies
Authors: Salahia Ghali , Chin Sook Cheng , Zealley Ian , White Richard D. 
Published: January 2020

AbstractPancreatic pathologies are varied and wide-ranging, and a multidisciplinary approach is essential for effective diagnosis and management. We describe image-guided percutaneous (nonendoscopic) interventions in the management of pancreatic disease, with emphasis on inflammatory and neoplastic pancreatic pathologies and on the transplanted pancreas. Image-guided treatments for the complications of pancreatitis include percutaneous interventions on simple and complex peripancreatic collections, pseudocysts, and fistulas. Vascular interventions predominantly focus on the treatment of pseudoaneurysms, hemorrhagic pseudocysts, and arteriovenous malformations. Emerging ablative techniques for pancreatic cancer are promising and include percutaneous radiofrequency ablation, microwave ablation, irreversible electroporation, and electrochemotherapy. Image-guided interventions on the transplanted pancreas commonly include percutaneous biopsy and drainage in addition to endovascular treatments of vascular complications.
Experimental research regarding the tribological properties of a hydraulic oil
Authors: Haragâş S , Pop D , Cristea F , Buiga O 
Published: January 2020

Abstract
This paper presents the results of the interesting experimental research regarding the influence of the additives over a hydraulic oil i.e. HFE46 (produced by ChemTrend [10]). In this vein, were used two types of additives (resulting two variants of oils denoted as sample C and D respectively) and was carried out a gravimetric determination (using the Timken test) analysing the hydraulic oils lubricating proprieties. Also, measurements regarding the vibrations in the tribotechnical system-TTS were conducted.
Preliminary results on nano-diamond and nano-graphite testing as additive for an engine lubrication oil
Authors: Moldovanu D , Molea A , Barabás I 
Published: January 2020

Abstract
An important amount of the fuel energy burned in an internal combustion engine is used to overcome the friction losses inside the engine. Developing advanced lubricants is one of the ways to improve the fuel efficiency and reducing the pollution caused by internal combustion engines. This paper presents tests done with 1% v/v nano-diamond and nano-graphite additives in engine oils, with bench tests on an air-cooled spark ignition engine (Honda GX 160) with a displacement of 118 cubic centimeters. Using the raw lubrication oil laboratory, tests were done to determine the viscosity, density and viscosity index using an Anton Paar SVM 3000 viscometer in comparison to the oil with nano-diamond and nano-graphite additives. The tests also revealed an average reduction in fuel consumption of 21% for the single cylinder engine in case of the oil with additives, for the entire speed range of the engine, showing a decrease of the fuel efficiency as the speed increases. The temperature of the exhaust manifold, outer side of the cylinder and the temperature of the oil pan were measured. By adding nano-diamond and nano-graphite additives to the lubricant oil, tests have revealed a reduction of the temperature of the exhaust manifold (with 11%), temperature on the outer side of the cylinder was reduced with 21% showing a clear friction reduction within the cylinder and piston-rings assembly. The temperature of the oil pan was reduced with 20%, showing a general reduction of the lubricating oil temperature which means a substantial reduction of the friction losses.
Technological and structural analysis of Al2O3 40TiO2 coating deposited on a shaft sleeve of hydraulic pump
Authors: Cîrlan Paleu C , Istrate B , Paleu V , Munteanu C 
Published: January 2020

Abstract
In the last decades, mechanical engineering applications have extensive use in many subdomains. Many researchers have used Al2O3 40TiO2 (AMDRY6250) type coatings that have a wide use of plasma jets, significantly improving their wear, corrosion resistance and heat shock properties. It is especially used for hydraulic components such as pumps, impellers, and blowers. The performance of Al2O3 40TiO2 layer is conditioned by a number of technological parameters of deposition, powder granulation and deposition incidence angle. In the present study, the authors will make sequential depositions of Al2O3 40TiO2 on the surface of a material coming from a hydraulic system. Microstructural analysis of optical microscopy, scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDAX) are performed both in the surface of the deposited material and in the section of the coated specimens, identifying the microstructure and the component phases. The authors highlighted the emergence of the “splat” type of formations that are specific to the ceramic coatings in the deposited layers and a good adhesion to the base material authorizing the use of this powder in the reconditioning of the hydraulic systems.
Friction and wear resistance of Al2O3 40TiO2 (AMDRY 6250) coating of a pump shaft sleeve bearing
Authors: Paleu V , Cîrlan Paleu C , Istrate B , Bhaumik S , Munteanu C 
Published: January 2020

Abstract
The equipment of wastewater treatment plants is continuously subjected to different kinds of wear, as corrosion, abrasion, cavitation, erosion etc. The most affected components are those of slurry pumps, the slurry producing intense abrasive wear. The service life of pumps (wear rings, sealing, bearings, impellers, and casings) can considerably be extended by proper coating. Before the implementation of a new coating in equipment, its friction and wear behaviour must be determined beside corrosion resistance. This paper presents the results of friction tests carried out on AMSLER machine. The tribological pair was composed by Al2O3 40TiO2 (AMDRY 6250) coating deposited on substrate of a pump shaft sleeve running against a rolling bearing steel disk in dry lubrication conditions. The experimental results are compared against those obtained for uncoated steel.
Delirium at the end of life
Authors: Agar Meera R 
Published: January 2020

Abstract
Delirium is highly prevalent in people with advanced life limiting illness(es), and current evidence can inform how we provide best delirium care in this setting. Whilst strategies to prevent and reverse delirium are the cornerstones of optimal care, the care for delirious patients who are approaching the end of life and their families pose specific challenges particularly if delirium is refractory flagging a grave prognosis. These include addressing additional supportive care needs, clinical decision-making about the degree of investigation and intervention, minimising distress from the symptoms of delirium itself and considering other concurrent problems contributing to agitation. A fine balance is needed to address other symptoms such as pain whilst minimizing psychoactive medication load. There is need for regular and clear information and communication about prognosis and goals of care. Witnessing a delirium episode in a loved one in close proximity to death requires consideration of the needs of the family into bereavement care.
Palliative care is person and family-centred care provided for a person with an active, progressive, advanced disease; who has little or no prospect of cure and who is expected to die, and for whom the primary treatment goal is to optimise quality of life. It is an approach which can be provided regardless of setting and diagnosis, and by both specialist palliative care teams and other health professionals.
PAX2 variant associated with bilateral kidney agenesis and broad intrafamilial disease variability
Authors: Rasmussen Maria , Nielsen Marlene Louise , Manak J Robert , Mogensen Helle , Lildballe Dorte L 
Published: January 2020

Abstract
Pathogenic variants in PAX2 have previously been associated with renal coloboma syndrome. Here we present a novel variant c.68T&gt;C associated with bilateral kidney agenesis, minimal change nephropathy, ureteropelvic junction obstruction, duplex kidney with hydronephrosis of upper pole system and bilateral kidney hypoplasia within the same family. Additionally, two family members were found to have optic nerve abnormalities further supporting the impact of the PAX2 variant. This is the first report of a PAX2 variant associated with bilateral kidney agenesis.
Non-extraction HPLC method for simultaneous measurement of dyphylline and doxofylline in serum
Authors: Tagliaro F , Dorizzi R , Frigerio A , Marigo M 
Published: January 2020

Abstract
A direct injection HPLC method for the simultaneous measurement of dyphylline and doxofylline in serum is reported. Chromatography is carried out with a "Pinkerton" internal surface reversed-phase column and phosphate buffer (0.1 mol/L, pH 6.8) as mobile phase. Absorbance at 275 nm is monitored. Only 10 microL of serum is required to detect less than 1 mg of each drug per liter in biological samples. The standard curve for the method is linear over the range 6-100 mg/L, and precision is acceptable for both drugs, with CVs of 2% and 1.5% for respective concentrations of 6.2 and 25 mg/L. None of the 76 drugs tested for interference affected the measurement of either drug. Four samples can be injected per hour. This method provides a fast, accurate way to monitor two interesting therapeutic agents used in chronic obstructive airway diseases.
Three commercial polyclonal immunoassays for cyclosporine in whole blood compared: 1. Results with patients' specimens
Authors: Strassman M J , Lensmeyer G L , Wiebe D A , Carlson I H 
Published: January 2020

Abstract
We assessed the performance of three commercially available polyclonal immunoassays for apparent cyclosporine in 120 whole-blood specimens collected from transplant recipients just before their next dose of cyclosporine (CsA). The assays were (a) Abbott's TDx fluorescent polarization immunoassay for CsA and its metabolites in whole blood; (b) the Sandoz radioimmunoassay (RIA); and (c) Incstar's Cyclo-Trac RIA. Mean respective CVs were 3.8%, 9.3%, and 24.3%. Analytical recovery was nearly 100% for concentrations up to 1000 micrograms/L for Incstar and up to 1500 micrograms/L for Abbott and Sandoz; linearity was compromised at greater concentrations. We also quantified the parent CsA concentrations by HPLC. Moreover, to follow day-to-day fluctuations in patients' "cyclosporine" concentrations with each method and to assess the impact these differences have on interpretation of the analytical results, we assayed serial specimens from six post-transplant patients. These showed significantly dissimilar, but parallel, results among the methods for any single sample. Occasionally, however, a result would not fit the established trend. Biases observed among the assays can be explained in part by the nonspecific antisera cross-reacting with CsA metabolites. Most important, we demonstrate that patients' results are not reliably interchangeable among the methods.
Revision of the oral glucose tolerance test: a pilot study
Authors: Schwartz J G , Phillips W T , Aghebat-Khairy B 
Published: January 2020

Abstract
Nausea and vomiting have been recurrent problems with the oral glucose tolerance tests (OGTT) used to diagnose diabetes. We believe the nausea is associated with delayed gastric emptying caused by the high osmolarity of the glucose solution. In our pilot study, both the "standard" 100-g glucose OGTT and our new modified (lower osmolar) glucose solution were evaluated. Considerably delayed gastric emptying (along with severe nausea) was consistently noted with the standard OGTT. No nausea and a much more rapid gastric emptying time were recorded when the modified glucose solution was administered. We were able to diagnose diabetes (by using Wilkerson's point system) when our modified OGTT was administered to type 2 diabetics. We plan to develop a more physiological, more reproducible, and better tolerated OGTT to diagnose diabetes more accurately in the general population.
Cerebrospinal fluid lipoperoxides quantified by liquid chromatography, and determination of reference values
Authors: Knight J A , McClellan L , Staheli J K 
Published: January 2020

Abstract
Cerebrospinal fluid lipoperoxides, measured as the malondialdehyde-thiobarbituric acid (MDA-TBA) adduct, were quantified by adapting the plasma liquid-chromatographic method of Wong et al. (Clin Chem 1987;33:214-20) to cerebrospinal fluid. Reference values for spinal fluid specimens from 91 adults, ages 17 to 95 y, and 37 children, ages 8 d to 8 y, were determined. Their concentrations were not significantly different (P = 0.222), adults having a mean (and SD) of 0.11 (0.06) mumol and children 0.10 (0.04) mumol of MDA per liter. Their ranges were 0.02-0.26 and 0.04-0.21 mumol of MDA per liter, respectively. We found concentrations in cerebrospinal fluid to be increased in several central nervous system disorders, including seizures, cerebral infarction, alcoholic encephalopathy, and, perhaps, prematurity. The presence of other thiobarbituric acid-reactive substances in cerebrospinal fluid stresses the importance of using highly specific techniques when lipoperoxides are measured in body fluids.
Evidence for interaction of human anti-idiotypic antibodies with CA 125 determination in a patient after radioimmunodetection
Authors: Reinsberg J , Heydweiller A , Wagner U , Pfeil K , Oehr P , Krebs D 
Published: January 2020

Abstract
Very high concentrations of CA 125 have been found in some ovarian cancer patients after repeated radioimmunodetection with anti-CA 125 antibodies [OC125-F(ab')2]. In one patient we measured a CA 125 concentration of 135,000 kilo-arb. units/L, using an enzyme immunoassay involving OC125 antibodies. With an immunoradiometric assay involving use of two new anti-CA 125 antibodies (B43.13 and B27.1), the CA 125 concentration was 34 kilo-arb. units/L, indicating a discrepancy. The component responsible for the high result in the enzyme immunoassay could be purified by immunoaffinity chromatography on Protein A-Sepharose. Furthermore this component bound to anti-human IgG-Sepharose in the same manner as did the serum IgG fraction. Adsorption of human anti-mouse antibodies present in the serum did not decrease the CA-125-like material. Binding of whole OC125 antibodies to the purified CA-125-like material was inhibited completely in the presence of CA 125 antigen. We infer that the false-positive CA 125 activity is ascribable to a human IgG directed against an idiotope of the OC125 antibody, which was induced by repeated application of OC125 antibodies. To avoid falsely positive results in patients receiving OC125 antibodies, CA 125 should be measured by an assay in which other antibodies are used.
Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age
Authors: Sandkamp M , Funke H , Schulte H , Köhler E , Assmann G 
Published: January 2020

Abstract
We quantified lipoprotein(a) [Lp(a)] immunochemically in young (less than 46 y) male survivors of myocardial infarction and in age-matched controls recruited from participants of the Prospective Cardiovascular Münster (PROCAM) study. We further determined apolipoprotein E polymorphism and measured triglycerides, total cholesterol, high- and low-density lipoprotein cholesterol (HDL and LDL), and apolipoproteins AI, AII, and B in the serum of these subjects. Lp(a) concentrations in serum were not correlated with other well-recognized risk factors for early myocardial infarction such as apolipoproteins AI and B, LDL cholesterol, and HDL cholesterol. Apolipoprotein E polymorphism did not affect Lp(a) concentrations, but had a major influence on apolipoprotein B concentration. Lp(a) concentrations were not influenced by age. Our data suggest that (a) an increased concentration of Lp(a) constitutes an independent risk factor for early myocardial infarction and (b) the concentrations of Lp(a) and LDL cholesterol (apolipoprotein B) in serum are under separate metabolic control.
Calculated values for low-density lipoprotein cholesterol in the assessment of lipid abnormalities and coronary disease risk
Authors: McNamara J R , Cohn J S , Wilson P W , Schaefer E J 
Published: January 2020

Abstract
Low-density lipoprotein (LDL) cholesterol concentrations are most commonly estimated by the formula LDL cholesterol = total cholesterol - [triglycerides (TG)/5 + high-density lipoprotein cholesterol], although alternative factors such as TG/6 have also been used. Using standardized, automated, enzymatic lipid assays, we analyzed 4797 plasma samples from normal and dyslipidemic adults, to compare LDL cholesterol concentrations obtained after ultracentrifugation with those calculated by several such methods (i.e., TG/4-TG/8). or TG concentrations less than or equal to 0.50 g/L, TG/4 agreed best with the direct assay; for TG of 0.51-2.00 g/L, TG/4.5 was best; and for TG of 2.01-4.00 g/L, TG/5 was best. Differences in estimated values were generally small, however. At TG greater than 4.00 g/L, none of the factors tested allowed a reliable estimate of LDL cholesterol. When TG were less than or equal to 4.00 g/L, 86% of estimated LDL cholesterol values were properly classified according to National Cholesterol Education Program cutpoints when the factor TG/5 was used. We conclude that a convenient direct method for measuring LDL cholesterol is needed but, until one is available, use of the factor TG/5 will assure that most individuals with TG less than or equal to 4.00 g/L, as measured in a standardized laboratory, can be reasonably well classified for risk of coronary artery disease.
Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum
Authors: Meulenberg P M , Hofman J A 
Published: January 2020

Abstract
We measured cortisol and cortisone in plasma--both total and free--and in saliva during the course of pregnancy and postpartum. Antepartum and postpartum concentrations and morning and afternoon concentrations of both steroids were compared. The mean concentrations of cortisol and cortisone increased towards term and were significantly greater at the end of pregnancy than postpartum, except for free cortisol in plasma in the afternoon. The daily rhythm of both steroids was maintained throughout pregnancy and postpartum. The correlations between salivary and plasma free concentrations of cortisol and cortisone as well as of the sum of cortisol + cortisone were highly significant. The mean concentrations of cortisone in saliva accurately reflected both total and free concentrations in plasma. For cortisol, however, the change of the concentrations in saliva, was somewhat different from that in plasma. Moreover, the mass ratio of plasma free cortisol to salivary cortisol was about 2, whereas for cortisone the ratio was only about 0.5, probably owing to the conversion of cortisol to cortisone by 11 beta-hydroxysteroid dehydrogenase in the salivary gland. Furthermore, the passage of cortisol and cortisone from plasma to saliva should not be regarded as simple diffusion, because in the first half of pregnancy the sum of the concentrations of cortisol + cortisone in saliva significantly exceeded the sum of their free concentrations in plasma.
Quantification of chloride in sweat with the Cystic Fibrosis Indicator System
Authors: Warwick W J , Hansen L G , Werness M E 
Published: January 2020

Abstract
We examined the relation between chloride concentration and the area of complexed chloride of Medtronic's Cystic Fibrosis Indicator System, using a high-resolution x-y coordinated digitizer to measure the circumference of the chloride precipitation ring. These digitized points were entered directly into an IBM PC computer, where the area of the chloride precipitation was calculated with use of a repetitive rectangular estimation program. Using these data, we determined the relationship between the area of chloride precipitation and the chloride concentration of the standard NaCl solutions. When the area of the ring of chloride precipitation in the system's patch is measured immediately after the sweat test is completed, the concentration of chloride in the sweat can be calculated with a reproducibility equal to that of the Gibson-Cooke sweat test.
Automated quantification of creatine kinase MB isoenzyme in serum by radial partition immunoassay, with use of the Stratus analyzer
Authors: Chapelle J P , el Allaf M 
Published: January 2020

Abstract
We evaluated the analytical and clinical performances of a new radial partition immunoassay for measuring the mass concentration of creatine kinase (CK)-MB in serum. All pipetting, washes, incubations and data reduction were performed in 8 min by the Stratus (Dade) fluorometric analyzer. Within-assay and between-assay CVs were respectively 5.5% and 8.4% at 21 micrograms/L, and 4.2% and 3.4% at 48 micrograms/L. Assaying serial dilutions of serum samples with high CK-MB concentrations demonstrated excellent linearity. Results of the Stratus technique correlated well (n = 115, r = 0.98) with those of the Tandem-E CKMB II assay. There was no interference from hemolysis, bilirubin, rheumatoid factor, or added CK-MM (up to 3500 U/L); consequently, CK-MB can be determined in undiluted serum, even in the presence of high total CK activity. The mean CK-MB concentration in 105 blood donors was 1.9 (SD 1.3) micrograms/L. For seven myocardial infarction patients who received prompt fibrinolytic therapy, the mean CK-MB concentration was 4.5 (SD 1.8) micrograms/L at admission, and maximum concentrations, 119 (SD 94) micrograms/L, were recorded 16 h later. CK-MB returned to concentrations less than 10 micrograms/L within 72 h.