bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in the Management of Cluster Headache
Authors: Villar-Martínez María Dolores , Puledda Francesca , Goadsby Peter J. 
Published: November 2020

Abstract
Purpose of review
Among the spectrum of pain conditions, cluster headache represents one of the most severe. Targeted therapies for cluster headache are evolving thus improving the available therapeutic armamentarium. A better understanding of the currently available therapies, as well as new and emerging options, may aide physicians to manage affected sufferers better by evolving treatment guidance.

Recent findings
While classic first-line medications are useful in some patients with cluster headache, they are often accompanied by significant side effects that limit their use. Recently, novel treatments with better tolerability and decreased medication interactions have proven to be effective. A remarkable example of this is the blockage of the calcitonin gene-related peptide pathway with monoclonal antibodies, which may be a key element in the future treatment of cluster headache. The sphenopalatine ganglion and vagus nerve perform a critical role in the regulation of pain and the trigeminal autonomic reflex. Neuromodulation therapies targeting these structures have shown excellent tolerability and few significant adverse events, constituting a promising form of treatment. Finally, several potential therapeutic targets are examined in this review, such as small molecule CGRP receptor antagonists, known as gepants, and serotonin receptor 5-HT1F receptor agonists: ditans.

Summary
In summary, a deepening of the understanding of cluster headache mechanisms in recent years has driven the evolution of sophisticated therapeutic approaches that could allow a new era in the treatment of this difficult condition.
Hippocampal Sector–Specific Metabolic Profiles Reflect Endogenous Strategy for Ischemia-Reperfusion Insult Resistance
Authors: Krupska Olga , Kowalczyk Tomasz , Beręsewicz-Haller Małgorzata , Samczuk Paulina , Pietrowska Karolina , Zabłocki Krzysztof , Kretowski Adam , Ciborowski Michal , Zabłocka Barbara 
Published: November 2020

AbstractThe gerbil is a well-known model for studying cerebral ischemia. The CA1 of the hippocampus is vulnerable to 5 min of ischemia, while the CA2–4 and dentate gyrus (DG) are resistant to it. Short-lasting ischemia, a model of transient ischemic attacks in men, results in CA1 neuron death within 2–4 days of reperfusion. Untargeted metabolomics, using LC-QTOF-MS, was used to enrich the knowledge about intrinsic vulnerability and resistance of hippocampal regions and their early post-ischemic response (IR). In total, 30 significant metabolites were detected. In controls, taurine was significantly lower and guanosine monophosphate was higher in CA1, as compared to that in CA2–4,DG. LysoPG and LysoPE were more abundant in CA1, while LysoPI 18:0 was detected only in CA2–4,DG. After IR, a substantial decrease in the citric acid level in CA1, an accumulation of pipecolic acid in both regions, and opposite changes in the amount of PE and LysoPE were observed. The following metabolic pathways were identified as being differentially active in control CA1 vs. CA2–4,DG: metabolism of taurine and hypotaurine, glycerophospholipid, and purine. These results may indicate that a regulation of cell volume, altered structure of cell membranes, and energy metabolism differentiate hippocampal regions. Early post-ischemia, spatial differences in the metabolism of aminoacyl-tRNA biosynthesis, and amino acids and their metabolites with a predominance of those which upkeep their well-being in CA2–4,DG are shown. Presented results are consistent with genetic, morphological, and functional data, which may be useful in further study on endogenous mechanisms of neuroprotection and search for new targets for therapeutic interventions.
The Uncertainty Paradox: Molar Mass of Enriched Versus Natural Silicon Used in the XRCD Method
Authors: Pramann Axel , Vogl Jochen , Rienitz Olaf 
Published: November 2020

AbstractThe X-ray crystal density method uses silicon spheres highly enriched in 28Si as a primary method for the dissemination of the SI base unit kilogram yielding smallest possible uncertainties associated with the mass m within a few parts in 10−8. This study compares different available and newly developed analytical methods and their results for the determination of the molar mass M of silicon highly enriched in 28Si (Me) and of silicon (Mx) with an almost natural isotopic distribution. While for Me relative uncertainties urel(Me) in the lower 10−9 range are obtained routinely, it was not possible to fall below a value of urel(Mx) < 4 × 10−6 in the case of natural silicon, which is approximately three orders of magnitude larger. The application of the state-of-the-art isotope ratio mass spectrometry accompanied with sophisticated thoroughly investigated methods suggests an intrinsic cause for the large uncertainty associated with the molar mass of natural silicon compared to the enriched material.
Aquatic plant, Ipomoea aquatica, as a potential low-cost adsorbent for the effective removal of toxic methyl violet 2B dye
Authors: Kua Tze Ling , Kooh Muhammad Raziq Rahimi , Dahri Muhammad Khairud , Zaidi Nur Afiqah Hazirah Mohamad , Lu YieChen , Lim Linda Biaw Leng 
Published: November 2020

AbstractIpomoea aquatica (IA) was investigated for its potential as a low-cost adsorbent to remove toxic methyl violet 2B (MV2B) dye in aqueous solutions. Optimising parameters such as the effects of contact time, medium pH and ionic strength (using NaCl, NaNO3, KCl and KNO3) were investigated. The results indicated that 150 min were sufficient for the adsorption to reach an equilibrium state and no adjustment of pH medium was necessary. Batch adsorption experiments such as adsorption isotherm, thermodynamics and kinetics were investigated and the experimental isotherm data were fitted to six isotherm models, namely Langmuir, Freundlich, Temkin, Dubinin-Radushkevich, Redlich-Peterson and Sips, with the latter being the best-fit isotherm model showing maximum adsorption capacity (qmax) of 267.9 mg g−1. Thermodynamics studies indicated adsorption of MV2B to be exothermic in nature, occurring spontaneously. The kinetics was best described by the pseudo-second-order model. Regeneration of IA pointed to its reusability, maintaining high adsorption capacity even up until Cycle 5 when treated with acid (HCl) and base (NaOH). Functional groups such as hydroxyl and amine groups which could be involved in the adsorption of MV2B were determined using FTIR spectroscopy, and the point of zero charge of IA was found to be at pH 6.81.
Preliminary investigation of the hydrocarbon generation potential from the post-rift Abbas shale Formation (Pliocene) in the Tihamah Basin, south-eastern Yemeni Red Sea
Authors: Hakimi Mohammed Hail , Gharib Abbas F. , Abidin Nor Syazwani Z. , Yahya Madyan M. A. 
Published: November 2020

AbstractPliocene shales included in the post-rift Abbas Formation were recovered from an exploratory well (Kathib-01) in the Tihamah Basin and geochemically analyzed. A preliminary evaluation of the organic facies of the Abbas shales and their petroleum generation potential was conducted based on basic organic geochemical results. Most Abbas shale samples had total organic carbon (TOC) contents < 1% and a fair source potential, while the remaining samples, with TOC contents > 1%, had a relatively good potential. Overall, the Rock–Eval hydrogen index values of the shales analyzed were between 96 and 234 mg of hydrocarbon per gram of TOC (mg HC/g TOC), indicating two dominant organic facies: types III and II/III kerogen, which indicate the presence of mainly gas- and oil-prone source rocks. We conclude that the Pliocene Abbas shales in the Tihamah Basin are still in a very early-mature stage (with respect to the oil window) and, hence, have not generated petroleum yet.
The mutation profile of differentiated thyroid cancer coexisting with undifferentiated anaplastic cancer resembles that of anaplastic thyroid cancer but not that of archetypal differentiated thyroid cancer
Authors: Mika Justyna , Łabaj Wojciech , Chekan Mykola , Abramowicz Agata , Pietrowska Monika , Polański Andrzej , Widłak Piotr 
Published: November 2020

AbstractDifferentiated thyroid cancer (DTC) has one of the lowest cancer mutational burdens, while anaplastic thyroid cancer (ATC) has a much higher mutation frequency. A fraction of ATC has an associated differentiated component, which suggests the coevolution of both cancers. Here, we aimed to compare mutation frequency in coexisting ATC and DTC diagnosed concurrently in the same thyroid gland (3 cases) as well as in archetypal DTC and ATC alone (5 cases each). Single-nucleotide variations (SNV) and copy number variations (CNV) were analyzed in each case based on the next-generation sequencing data. We found a similar extent of mutational events, both SNV and CNV, in undifferentiated and differentiated components of thyroid cancers coexisting in one patient. The magnitude of these mutations was comparable to the level of mutations observed in ATC alone; yet, it was much higher than in archetypal DTC. This suggested that, despite histopathological features of differentiated tumors, molecular characteristics of such cancers coexisting with ATC and archetypal DTC could be significantly different. Pairwise comparison of mutational profiles of coexisting cancers enabled assumption on the possible evolution of both components, which appeared distinct in 3 analyzed cases. This included independent development of ATC and DTC diagnosed concurrently in two lobes of the same thyroid, as well as the development of anaplastic and differentiated cancer from the common ancestor that putatively gained a key driver mutation (BRAFV600E or KRASQ61R), which was followed either by early or late molecular separation of both cancers.
Investigation on compatibility and thermal reliability of phase change materials for low-temperature thermal energy storage
Authors: Devanuri Jaya Krishna , Gaddala Uma Maheswararao , Kumar Vikas 
Published: November 2020

AbstractTwo of the important aspects for the successful utilization of phase change materials (PCMs) for thermal energy storage systems are compatibility with container materials and stability. Therefore, the present study is focused on testing the corrosion resistance and surface characteristics of metals in contact with PCMs and thermal behavior of PCMs with heating/cooling cycles. The PCM selection is made by targeting low temperature (<100 °C) heat storage applications. The PCMs considered are paraffin wax, sodium acetate tri-hydrate, lauric acid, myristic acid, palmitic acid, and stearic acid. The metal specimens tested are aluminum, copper, and stainless steel because of their wide usage in thermal equipment. The tests are performed by the method of immersion corrosion test, and ASTM G1 standards are followed. The experiments are carried out at 80 °C and room temperature (30 °C) for the duration of 10, 30, and 60 days. Pertaining to thermal stability 1500 melting/freezing cycles are performed. Investigation has been carried out in terms of corrosion rate, SEM analysis of metal specimens, appearance of PCMs, and variation of thermophysical properties at 0th, 1000th, and 1500th thermal cycles. The most affected area of corrosion, including the dimension of pits, is presented, and comparison is made. Based on the corrosion experiments, recommendations are made for the metal–PCM pairs. Pure sodium acetate trihydrate is observed to suffer from phase segregation and supercooling. After 1500 thermal cycles, the variation in melting and freezing point temperatures for rest of the five PCMs are in the range of − 1.63 to 1.57 °C and − 4.01 to 2.66 °C. Whereas, reduction in latent heat of melting and freezing are in the range of 17.6–28.95% and 15.2–26.78%.
Facultative-anaerobic microbial digestion of coal preparation waste and use of effluent solids to enhance plant growth in a sandy soil
Authors: Fallgren Paul H. , Chen Liang , Peng Min , Urynowicz Michael A. , Jin Song 
Published: November 2020

AbstractCoal preparation solid waste, which is a major environmental issue for coal-producing areas in China, may be microbiologically digested and transformed into a product suitable as a soil amendment to increase soil organic matter content and prevent and enhance plant/crop growth. Coal preparation waste collected from a coal sorting plant in Inner Mongolia, China was digested in bioreactors inoculated with microbial enrichments prepared from activated sludge and cow manure. The effluent solids from the coal preparation waste bioreactors were analyzed for their suitability as organic soil amendments, which complied with China standards. Plant growth tests were conducted in sandy soil from a semi-arid region in Colorado, which was amended with the effluent solids. Kentucky bluegrass (Poa pratensis L.) and chives (Allium schoenoprasum) were used as the representative plants for the growth tests, where results indicated substantially higher yields of Kentucky bluegrass and chives for the sandy soils amended with the effluent solids when compared to a commercial organic fertilizer. The number and average length of Kentucky bluegrass shoots were 10 and 5.1 times higher, respectively, in soils amended with the effluent solids. Similarly, the number and average length of chives shoots were 10 and 1.7 times higher, respectively, in soils amended with the effluent solids. Overall, the microbial digestion of coal preparation waste for application as an organic soil amendment is a viable alternative and beneficial use of coal preparation solid waste.
A physical model study of surrounding rock failure near a fault under the influence of footwall coal mining
Authors: Zhang Shukun , Lu Lu , Wang Ziming , Wang Shuda 
Published: November 2020

AbstractA study of the deformation of the surrounding rock and coal pillars near a fault under the influence of mining is conducted on a physical model for the design of coal pillars to support and maintain the roofs of adjacent fault roadways. This research is based on the 15101 mining face in the Baiyangling Coal Mine, Shanxi, China, and uses simulation tests similar to digital speckle test technology to analyse the displacement, strain and vertical stress fields of surrounding rocks near faults to determine the influence of the coal pillar width. The results are as follows. The surrounding rock of the roadway roof fails to form a balance hinge for the massive rock mass. The vertical displacement, vertical strain and other deformation of the surrounding rock near the fault increase steeply as the coal pillar width decreases. The steep increase in deformation corresponds to a coal pillar width of 10 m. When the coal pillar width is 7.5 m, the pressure on the surrounding rock near the footwall of the fault suddenly increases, while the pressure on the hanging wall near the fault increases by only 0.35 MPa. The stress of the rock mass of the hanging wall is not completely shielded by the fault, and part of the load disturbance is still transmitted to the hanging wall via friction. The width of the fault coal pillars at the 15101 working face is determined to be 7.5 m, and the monitoring data verify the rationality of the fault coal pillars.
Electrified powertrains for wheel-driven non-road mobile machinery
Authors: Ratzinger Josef Markus , Buchberger Simon , Eichlseder Helmut 
Published: November 2020

AbstractAlready enacted carbon-dioxide (CO2) limiting legislations for passenger cars and heavy duty vehicles, drive motivations to consider electrification also in the sector of non-road mobile machinery. Up to now, only the emissions of the vehicles themselves have been restricted. However, to capture the overall situation, a more global assessment approach is necessary. The study described in this article applies a tank-to-wheel and an extended well-to-wheel approach based on simulations to compare three different powertrains: a battery electric drive, a parallel electric hybrid drive, and a series electric hybrid drive. The results show that electrification is not per se the better solution in terms of keeping CO2 emissions at a minimum, as battery electric powertrains are accountable for the lowest as well as the highest possible CO2 emissions of all powertrains compared. A battery electric machine is not economically competitive if its battery has to last a whole working day. Parallel hybrid systems do not achieve much of an advantage in terms of CO2 emissions. In this global assessment approach, the most promising propulsion system for wheel-driven-mobile-machinery appears to be the series hybrid system, which shows to offer up to 20% of CO2 saving potential compared to the current machine.
Reliability studies on reinforced concrete beam subjected to bending forces with natural stone as coarse aggregate
Authors: Kolo Daniel Ndakuta , Aguwa James Isiwu , Tsado Theophilus Yisa , Abdullahi Mohammed , Yusuf Abdulazeez , Oritola Sikiru Folahan 
Published: November 2020

AbstractThis paper presents the results of structural reliability analysis of a structural element (beam) in building using First-order reliability method (FORM) to ascertain the level of safety. The natural stone (NS) which is the by-product of Precambrian deposits of the Bida trough was used as coarse aggregate: unwashed and washed aggregates were used. A total of 80 concrete cubes of 150 mm × 150 mm × 150 mm were cast and used for this study, sensitivity analysis was conducted by varying the span, depth, effective depth, area of shear reinforcement and dead load of the beam in bending. The result of the sensitivity analysis revealed that the beam utilising unwashed and washed NS are both structurally safe at a span of 3000 mm with probabilities of failure of 9.20 × 10–5 and 2.06 × 10–8 and both safe at a depth of 600 mm with probabilities of failure of 4.19 × 10–4 and 2.602 × 10–4, respectively, in bending.
Temporal Changes in the Causes of the Observed Oxygen Decline in the St. Lawrence Estuary
Authors: Jutras M. , Dufour C. O. , Mucci A. , Cyr F. , Gilbert D. 
Published: November 2020

AbstractOxygen concentrations in the deep waters of the Lower St. Lawrence Estuary have decreased by 50% over the past century. The drivers of this decrease are investigated by applying an extended Optimum Multiparameter analysis to a time series of physical and biogeochemical observations of the St. Lawrence Estuarine System in the 1970s and from late 1990s to 2018. This method reconstructs the relative contributions of the two major water masses feeding the system, the Labrador Current Waters (LCW) and the North Atlantic Central Waters (NACW), as well as oxygen utilization, and accounts for diapycnal mixing. The causes of the oxygen decline varied over the last 5 decades. Between the 1970s and late 1990s, the decrease was mainly driven by biogeochemical changes through an increase in microbial oxygen utilization in the St. Lawrence Estuary in response to warmer temperatures and eutrophication and lower oxygen concentrations in LCW and NACW. Between 2008 and 2018, the decrease was mainly driven by circulation changes in the western North Atlantic associated with a reduced inflow of high‐oxygenated LCW to the deep waters of the system in favor of low‐oxygenated NACW, reaching a historical minimum in 2016. The LCW:NACW ratio is strongly correlated with the volume transport of the Scotian shelf‐break current, an extension of the Labrador Current. These results highlight the primary role of the Labrador Current in determining the oxygen concentration and other water properties of the St. Lawrence Estuarine System and on the western North Atlantic continental shelf and slope.
Attenuation of Ocean Surface Waves in Pancake and Frazil Sea Ice Along the Coast of the Chukchi Sea
Authors: Hošeková Lucia , Malila Mika P. , Rogers W. Erick , Roach Lettie A. , Eidam Emily , Rainville Luc , Kumar Nirnimesh , Thomson Jim 
Published: November 2020

AbstractAlaskan Arctic coastlines are protected seasonally from ocean waves by the presence of coastal and shorefast sea ice. This study presents field observations collected during the autumn 2019 freeze up near Icy Cape, a coastal headland in the Chukchi Sea of the Western Arctic. The evolution of the coupled air‐ice‐ocean‐wave system during a 4‐day wave event was monitored using drifting wave buoys, a cross‐shore mooring array, and ship‐based measurements. The incident wavefield with peak period of 2.5 s was attenuated by coastal pancake and frazil sea ice, reducing significant wave height by 40% over less than 5 km of cross‐shelf distance spanning water depths from 13 to 30 m. Spectral attenuation coefficients are evaluated with respect to wave and ice conditions and the proximity to the ice edge. Attenuation rates are found to be three times higher within 500 m of the ice edge, relative to values farther in the ice cover. Attenuation coefficients are in the range of 〈2.3, 2.7〉x10‐3 m−1, and follow a power‐law dependence on frequency.
Seasonal Stages of Chlorophyll‐a Vertical Distribution and Its Relation to the Light Conditions in the Black Sea From Bio‐Argo Measurements
Authors: Kubryakov A. A. , Mikaelyan A. S. , Stanichny S. V. , Kubryakova E. A. 
Published: November 2020

AbstractThe year‐to‐year seasonal variability of the vertical distribution of concentration of chlorophyll‐a (Chla) in the Black Sea, its relation to light (photosynthetically available irradiance [PAR]), and mixing conditions were studied based on the 6‐year (2014–2019) measurements of Bio‐Argo floats. Variations in PAR caused by changes in incoming solar radiation and light attenuation determine the position of the deep chlorophyll maximum (DCM). During all seasons, the DCM was located between isolume of daily integrated PAR of 0.080 and 10.0 mole photons m−2 d−1. Analysis of Bio‐Argo data allowed to distinguish seven different stages of Chla seasonal variability. In February, the minimum of Chla in the entire water column was often observed in areas with a deep mixed layer (Stage 1), followed by the March early spring peak, occupying both the mixed layer and the seasonal thermocline (Stage 2). In April–May, Chla decreased throughout the 0–40 m layer, which was accompanied by the maximum in light penetration and an increase in Chla in the deepest layers (Stage 3). In summer, two deep peaks of Chla were distinguished: the first, a thin and shallow peak in June, and the second, a large and deeper peak in August (Stage 4 and 5). The August peak was followed by the deepest seasonal minimum of Chla in September–October, coincided with the autumn rise of the zooplankton biomass (Stage 6). Autumn–winter convection in November–January led to the third seasonal peak of Chla (Stage 7). The study discusses the role of various abiotic and biotic factors in the formation of each of these stages.