bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absolute B cell counts in blood predict long-term response in follicular lymphoma patients treated with rituximab without chemotherapy
Authors: Junlén Henna-Riikka , Lockmer Sandra , Kimby Eva , Wahlin Björn Engelbrekt 
Published: August 2020

AbstractRituximab monotherapy is widely used for follicular lymphoma. However, there are no established predictors for response or response duration. We analyzed the long-term prognostic relevance of pre-treatment absolute blood counts of lymphocytes with subsets and monocytes in 265 follicular lymphoma patients, uniformly treated with rituximab without chemotherapy, in two Nordic Lymphoma Group trials. There were 265 previously untreated, stage II–IV follicular lymphoma patients with a median follow-up of over 10 years. Absolute B cell counts ≥ median (0.09 × 109/L) were an independent predictor for shorter time to next treatment or death (multivariable analysis P = 0.010). In univariate analysis, absolute monocyte counts ≥ median (0.5 × 109/L) did not correlate with time to next treatment or death, but with inferior overall survival (P = 0.034). Absolute T cell or T cell subset counts were not predictive for outcome. High absolute B cell counts, possibly reflecting circulating lymphoma cells, have an unfavorable impact on time to next treatment or death in patients treated with rituximab without chemotherapy.
Robust post-disaster route restoration
Authors: Caunhye Aakil M. , Aydin Nazli Yonca , Duzgun H. Sebnem 
Published: August 2020

AbstractRoute restoration is considered to be a task of foremost priority in disaster relief. In this paper, we propose a robust optimization approach for post-disaster route restoration under uncertain restoration times. We present a novel decision rule based on restoration time ordering that yields optimal restoration sequencing and propose conditions for complexity reduction in the model and prove probability bounds on the satisfaction of these conditions. We implement our models in a realistic study of the 2015 Gorkha earthquake in Nepal.
A framework for facial age progression and regression using exemplar face templates
Authors: Elmahmudi Ali , Ugail Hassan 
Published: August 2020

AbstractTechniques for facial age progression and regression have many applications and a myriad of challenges. As such, automatic aged or de-aged face generation has become an important subject of study in recent times. Over the past decade or so, researchers have been working on developing face processing mechanisms to tackle the challenge of generating realistic aged faces for applications related to smart systems. In this paper, we propose a novel approach to try and address this problem. We use template faces based on the formulation of an average face of a given ethnicity and for a given age. Thus, given a face image, the target aged image for that face is generated by applying it to the relevant template face image. The resulting image is controlled by two parameters corresponding to the texture and the shape of the face. To validate our approach, we compute the similarity between aged images and the corresponding ground truth via face recognition. To do this, we have utilised a pre-trained convolutional neural network based on the VGG-face model for feature extraction, and we then use well-known classifiers to compare the features. We have utilised two datasets, namely the FEI and the Morph II, to test, verify and validate our approach. Our experimental results do suggest that the proposed approach achieves accuracy, efficiency and possess flexibility when it comes to facial age progression or regression.
Die Einstellung von Patienten in geriatrischer Rehabilitation zu Pflegeheimen
Authors: Schwind Natalie , Jahn Georg 
Published: August 2020

Zusammenfassung
Hintergrund
Mit Erreichen des höheren Lebensalters nehmen unterstützende Wohnformen eine immer wichtigere Rolle ein. Eingeschränkte Selbstständigkeit kann dazu führen, dass ein Umzug in ein Pflegeheim unabdingbar ist. Die Einstellung zu Pflegeheimen ist von großer Bedeutung sowohl für die Vorbereitung auf diesen Fall als auch für die psychische Reaktion auf sein Eintreten, wurde allerdings bisher kaum näher beforscht.

Ziel der Arbeit (Fragestellung)
Das Ziel dieser Untersuchung ist herauszufinden, wie Pflegeheime von älteren Menschen je nach ihrem subjektiven Kontrollerleben, ihrem Informationsstand und ihren Erfahrungen bewertet werden.

Material und Methoden
Zu Einstellungen gegenüber Pflegeheimen wurden insgesamt 150 geriatrische Rehabilitationspatienten mit einer ersten Fragebogenversion (n = 64) oder einer revidierten Fassung (n = 86) befragt.

Ergebnisse
Mittels Polaritätsprofil konnte eine eher positive Einstellung zu Pflegeheimen beobachtet werden, jedoch wurden bei freiem Antwortformat überwiegend negative Assoziationen geäußert. Der Großteil der Probanden hat eine ängstliche Haltung zu einem Umzug in ein Pflegeheim. Stärkeres Kontrollerleben, ein besserer Informationsstand und positive Erfahrungen mit Pflegeheimen stehen mit einer positiven Haltung zum Umzug in ein Pflegeheim im Zusammenhang.

Diskussion
Mit Blick auf geäußerte Ängste, einen verbreitet geringen Informationsstand und die starke Abwehrhaltung einiger Befragter gilt es, die Betroffenen proaktiv zu informieren und stärker in die Entscheidungen für eine Wohnoption einzubinden. Neueste Entwicklungen zu aussagekräftigerer Qualitätsdarstellung der Pflegeheime können dabei unterstützen.
Combined low vitamin D and K status amplifies mortality risk: a prospective study
Authors: van Ballegooijen Adriana J. , Beulens Joline W. J. , Kieneker Lyanne M. , de Borst Martin H. , Gansevoort Ron T. , Kema Ido P. , Schurgers Leon J. , Vervloet Marc G. , Bakker Stephan J. L. 
Published: August 2020

Abstract
Objective
To explore the association of both plasma vitamin D and K concentrations with all-cause mortality, cardiovascular mortality, and cardiovascular events in the general population.

Methods
We studied 4742 participants of the Prevention of REnal and Vascular ENd-Stage Disease (PREVEND) Study. At baseline, vitamin D and K status was determined by measurement of 25-hydroxyvitamin D [25(OH)D] and dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), respectively. Patients were categorized into: 25(OH)D < 50 or ≥ 50 nmol/L and dp-ucMGP < 361 or ≥ 361 pmol/L with 25(OH)D > 75 nmol/L and dp-ucMGP < 361 pmol/L as reference. Cause of death was coded according to International Classification of Diseases 9&10 codes from the 2001-2003 examination until date of death/event or censoring date (January 1st, 2017).

Results
Mean age was 52.6 ± 11.9 years and 2513 (53%) were female. During a median of 14.2 year follow-up, 620 participants died of which 142 were due to cardiovascular causes. Combined low vitamin D and K status was present in 970 participants (20%) and was associated with a greater risk of all-cause mortality compared to high vitamin D and high vitamin K status group (n = 1424) after adjusting for potential confounders: hazard ratio 1.46 (95% confidence intervals 1.12–1.90). We observed similar trends, albeit non-significant for cardiovascular mortality, and cardiovascular events: 1.42 (0.79–2.55), 1.28 (0.93–1.77), respectively.

Conclusions
Combined low vitamin D and K status are associated with increased all-cause mortality risk and possibly with cardiovascular mortality and cardiovascular events compared with adequate vitamin D and K status. Future studies should investigate the effect of combined vitamin D and K supplementation on clinical outcomes.
Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide
Authors: Hassenberg Christoph , Clausen Florian , Hoffmann Grete , Studer Armido , Schürenkamp Jennifer 
Published: August 2020

Abstract(−)-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (−)-11-hydroxy-Δ-9-tetrahydrocannabinol ((−)-11-OH-Δ-9-THC), which is psychoactive, and to (−)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC-COOH), which is psychoinactive. It is glucuronidated during phase II metabolism. The biotransformation of (−)-Δ-9-tetrahydrocannabinol-glucuronide ((−)-Δ-9-THC-Glc) and (−)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol-glucuronide ((−)-Δ-9-THC-COOH-Glc) is well understood, which is mainly due to the availability of commercial reference standards. Since such a standardized reference is not yet available for (−)-11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide ((−)-11-OH-Δ-9-THC-Glc), its biotransformation is harder to study and the nature of the glucuronide bonding—alcoholic and/or phenolic—remains unclear. Consequently, the aim of this study was to investigate the biotransformation of (−)-11-OH-Δ-9-THC-Glc in vitro as well as in vivo and to identify the glucuronide by chemically synthesis of a reference standard. For in vitro analysis, pooled human S9 liver fraction was incubated with (−)-Δ-9-THC. Resulting metabolites were detected by high-performance liquid chromatography system coupled to a high-resolution mass spectrometer (HPLC-HRMS) with heated electrospray ionization (HESI) in positive and negative full scan mode. Five different chromatographic peaks of OH-Δ-9-THC-Glc have been detected in HESI positive and negative mode, respectively. The experiment set up according to Wen et al. indicates the two main metabolites being an alcoholic and a phenolic glucuronide metabolite. In vivo analysis of urine (n = 10) and serum (n = 10) samples from cannabis users confirmed these two main metabolites. Thus, OH-Δ-9-THC is glucuronidated at either the phenolic or the alcoholic hydroxy group. A double glucuronidation was not observed. The alcoholic (−)-11-OH-Δ-9-THC-Glc was successfully chemically synthesized and identified the main alcoholic glucuronide in vitro and in vivo. (−)-11-OH-Δ-9-THC-Glc is the first reference standard for direct identification and quantification. This enables future research to answer the question whether phenolic or alcoholic glucuronidation forms the predominant way of metabolism.
Progression of sleep disturbances in Parkinson’s disease: a 5-year longitudinal study
Authors: Xu Zheyu , Anderson Kirstie N. , Saffari Seyed Ehsan , Lawson Rachael A. , Chaudhuri K. Ray , Brooks David , Pavese Nicola 
Published: August 2020

Abstract
Background
Sleep disorders can occur in early Parkinson’s disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored.

Objective
To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia, and probable REM sleep behavior disorder (pRBD) in early PD.

Methods
Data were obtained from the Parkinson’s Progression Markers Initiative (PPMI). EDS, insomnia, and pRBD were defined using the Epworth Sleepiness Scale, MDS-UPDRS Part I sub-item 1.7, and RBD screening questionnaire.

Results
218 PD subjects and 102 controls completed 5 years of follow-up. At baseline, 69 (31.7%) PD subjects reported one type of sleep disturbance, 25 (11.5%) reported two types of sleep disturbances, and three (1.4%) reported all three types of sleep disturbances. At 5 years, the number of PD subjects reporting one, two, and three types of sleep disturbances was 85 (39.0%), 51 (23.4%), and 16 (7.3%), respectively. Only 41(18.8%) patients were taking sleep medications. The largest increase in frequency was seen in insomnia (44.5%), followed by EDS (32.1%) and pRBD (31.2%). Insomnia was the most common sleep problem at any time over the 5-year follow-up. The frequency of sleep disturbances in HCs remained stable.

Conclusions
There is a progressive increase in the frequency of sleep disturbances in PD, with the number of subjects reporting multiple sleep disturbances increasing over time. Relatively a few patients reported multiple sleep disturbances, suggesting that they can have different pathogenesis. A large number of patients were not treated for their sleep disturbances.
Management of patients with neuromuscular disorders at the time of the SARS-CoV-2 pandemic
Authors: Costamagna Gianluca , Abati Elena , Bresolin Nereo , Comi Giacomo Pietro , Corti Stefania 
Published: August 2020

AbstractThe novel Coronavirus disease-19 (COVID-19) pandemic has posed several challenges for neuromuscular disorder (NMD) patients. The risk of a severe course of SARS-CoV-2 infection is increased in all but the mildest forms of NMDs. High-risk conditions include reduced airway clearance due to oropharyngeal weakness and risk of worsening with fever, fasting or infection Isolation requirements may have an impact on treatment regimens administered in hospital settings, such as nusinersen, glucosidase alfa, intravenous immunoglobulin, and rituximab infusions. In addition, specific drugs for SARS-CoV2 infection under investigation impair neuromuscular function significantly; chloroquine and azithromycin are not recommended in myasthenia gravis without available ventilatory support and prolonged prone positioning may influence options for treatment. Other therapeutics may affect specific NMDs (metabolic, mitochondrial, myotonic diseases) and experimental approaches for Coronavirus disease 2019 may be offered “compassionately” only after consulting the patient’s NMD specialist. In parallel, the reorganization of hospital and outpatient services may change the management of non-infected NMD patients and their caregivers, favouring at-distance approaches. However, the literature on the validation of telehealth in this subgroup of patients is scant. Thus, as the first wave of the pandemic is progressing, clinicians and researchers should address these crucial open issues to ensure adequate caring for NMD patients. This manuscript summarizes available evidence so far and provides guidance for both general neurologists and NMD specialists dealing with NMD patients in the time of COVID-19.
Congenital diaphragmatic hernia—does the presence of a hernia sac improve outcome? A systematic review of published studies
Authors: Raitio Arimatias , Salim Adeline , Losty Paul D. 
Published: August 2020

AbstractEarly reports have suggested survival benefits associated with a hernia sac in congenital diaphragmatic hernia (CDH). However, these studies have included only small subsets of patients. This systematic review aimed to evaluate differences in outcomes of CDH newborns with and without a hernia sac. PubMed and Embase databases were searched using relevant key terms. Papers were independently reviewed by two authors with final selection approved by the senior author. Original search retrieved 537 papers; the final review included 8 studies (n = 837 patients). There were 168 CDH patients (20%) with a hernia sac with an overall survival of 93% vs 73% for CDH newborns without a sac (p < 0.001). Twenty-three percent of patients with a CDH sac required diaphragm patch repair vs 44% patients without a sac (p < 0.001). Pulmonary hypertension was manifested in 44% of CDH babies with a hernia sac vs 64% without a sac (p < 0.001). Three studies compared ECMO requirement: 15% with a hernia sac and 34% without sac, p < 0.001.Conclusion: This study shows significant survival benefits in newborns associated with presence of a CDH sac. This may be likely related to these infants having more favourable physiology with less severe pulmonary hypertension and/or smaller anatomical defects requiring primary closure only.

What is Known:• Early reports have suggested survival benefits associated with a hernia sac in CDH.• Previous studies have included only a small number of patients.

What is New:• A systematic review of published studies clearly shows that CDH newborns with a hernia sac have better overall survival outcomes and less severe pulmonary hypertension.• ECMO utilization and patch repair were also less often required in newborns with a hernia sac.
Trophic position, elemental ratios and nitrogen transfer in a planktonic host–parasite–consumer food chain including a fungal parasite
Authors: Sánchez Barranco Virginia , Van der Meer Marcel T. J. , Kagami Maiko , Van den Wyngaert Silke , Van de Waal Dedmer B. , Van Donk Ellen , Gsell Alena S. 
Published: August 2020

AbstractParasitism is arguably the most commonly occurring consumer strategy. However, only a few food web studies assess how well stable isotopes reflect the trophic position of parasitic consumers and results are variable. Even fewer studies have measured the nutrient transfer by parasitic consumers, hindering an assessment of their role in nutrient transfer through food webs. Here we used a food chain consisting of a diatom as host, a chytrid as its parasitic consumer and a rotifer as the predatory consumer of the chytrid, to assess the trophic position of all three food-chain components using their natural 13C and 15N isotope signatures, and to measure the nitrogen transfer from the host via the chytrid to the rotifer by tracing 15N of a labelled host up the food chain. Additionally, we measured the carbon to nitrogen (C:N) ratios of all food-chain components. Natural isotope abundance results showed no clear 15N enrichment in the chytrid or rotifer relative to the primary producer. However, estimates of nitrogen transfer indicated that about 14% of host nitrogen was transferred per day from host to chytrid during infection epidemics and that some of this nitrogen was also transferred onward to the rotifer. Moreover, C:N ratios decreased with trophic level, suggesting that the chytrid provided a high-quality food source to the rotifer. In conclusion, our results support the “mycoloop”. The mycooloop proposes that chytrid infections allow the transfer of nutrients bound in large, inedible phytoplankton to zooplankton through the production of edible transmission spores, thereby rerouting nutrients back into the food web.
Application of a novel self-assembling peptide to prevent hemorrhage after EMR, a feasibility and safety study
Authors: Soons Elsa , Turan Ayla , van Geenen Erwin , Siersema Peter 
Published: August 2020

Abstract
Background
A novel self-assembling peptide (SAP) can be applied to the post-endoscopic mucosal resection (EMR) defect to treat oozing bleedings. It has been suggested to stimulate early healing of damaged vessels. We hypothesized that SAP application could prevent delayed bleeding (DB) after EMR and performed a prospective cohort study to determine feasibility and safety.

Methods
A total of 48 consecutive patients who underwent EMR between June 2018 and August 2019 for large lesions in the esophagus, duodenum (> 1 cm) or colorectum (> 2 cm) were treated with adjuvant SAP application. Duration and ease of SAP application were measured, as well as DB outcome.

Results
The EMR defects of 48 patients were treated with SAP; 17 in the esophagus, 13 in the duodenum and 18 in the colorectum. SAP was easy to apply on the EMR defect with a median duration of 2.0 min. A dose of 3 cc was generally enough to cover a defect between 10 and 50 mm. An exploratory analysis of the prophylactic ability of SAP showed that 15.9% of patients (7/44) treated with SAP still had a DB, mostly in the duodenum (4/11). No adverse events related to gel exposure were reported.

Conclusions
SAP application after EMR was found to be feasible and safe, and did not delay the procedure; however, DB was still relatively common. Future comparative studies are needed to evaluate whether SAP is able to reduce DB after EMR, particularly for lesions with an increased bleeding risk, such as in the duodenum.
Kyphotic deformity of the lumbar spine due to a monostotic fibrous dysplasia of the second lumbar vertebra: a case report and its surgical management
Authors: Stocsits Anna , Lener Sara , Girod Pierre Pascal , Abramovič Anto , Thomé Claudius , Hartmann Sebastian 
Published: August 2020

AbstractMonostotic fibrous dysplasia (MFD) of the lumbar spine represents an exceedingly rare lesion. A 26-year-old patient presented with a progressive osteolytic lesion of the vertebral body L2 and the diagnosis of MFD. A minimally invasive left-sided eXtreme Lateral Interbody Fusion (XLIF) approach with resection of the vertebral body L2 with placement of a mesh cage was performed. No complications were observed perioperatively and the symptoms rapidly improved. Minimally invasive piecemeal resection with a combined dorsolateral approach showed a favorable clinical and radiological outcome and seems to be a safe and reliable technique for MFD.
The Effect of Phantom Stimulation and Pseudomonophasic Pulse Shapes on Pitch Perception by Cochlear Implant Listeners
Authors: Lamping Wiebke , Deeks John M. , Marozeau Jeremy , Carlyon Robert P. 
Published: August 2020

AbstractIt has been suggested that a specialized high-temporal-acuity brainstem pathway can be activated by stimulating more apically in the cochlea than is achieved by cochlear implants (CIs) when programmed with contemporary clinical settings. We performed multiple experiments to test the effect on pitch perception of phantom stimulation and asymmetric current pulses, both supposedly stimulating beyond the most apical electrode of a CI. The two stimulus types were generated using a bipolar electrode pair, composed of the most apical electrode of the array and a neighboring, more basal electrode. Experiment 1 used a pitch-ranking procedure where neural excitation was shifted apically or basally using so-called phantom stimulation. No benefit of apical phantom stimulation was found on the highest rate up to which pitch ranks increased (upper limit), nor on the slopes of the pitch-ranking function above 300 pulses per second (pps). Experiment 2 used the same procedure to study the effects of apical pseudomonophasic pulses, where the locus of excitation was manipulated by changing stimulus polarity. A benefit of apical stimulation was obtained for the slopes above 300 pps. Experiment 3 used an adaptive rate discrimination procedure and found a small but significant benefit of both types of apical stimulation. Overall, the results show some benefit for apical stimulation on temporal pitch processing at high pulse rates but reveal that the effect is smaller and more variable across listeners than suggested by previous research. The results also provide some indication that the benefit of apical stimulation may decline over time since implantation.
Transitional justice and authoritarian backsliding
Authors: Nalepa Monika 
Published: August 2020

AbstractCan a lack of transitional justice contribute to democratic backsliding? This paper uses the case of Poland to argue that selective enforcement of transitional justice can be linked to democratic erosion. In doing so, the paper adjudicates between two theories of democratic backsliding. The first, advanced by Milan Svolik, argues that elite polarization drives erosion: when political candidates are ideologically far apart, citizens who strongly prefer one over the other may turn a blind eye to antidemocratic transgressions by their preferred candidate to prevent the competing candidate from winning. The second theory, presented by Nalepa, Vanberg, and Ciopris (NVC), describes an equilibrium where voters are uncertain whether the candidate they are dealing with is a closet autocrat or an ideological incumbent, but reelect him into office regardless. This theory posits that a closet autocrat is reelected into office because his first period actions are identical to those of an ideological incumbent. I argue that judiciary reforms in Poland reflect exactly the kind of incumbent actions that are consistent both with the actions of an ideological incumbent and with the actions of a closet autocrat. Using survey data from Poland, I find evidence of elite polarization, offering support for the first theory, but also find ample evidence of polarization in the electorate and of a belief structure supportive of the equilibrium from NVC. I present Hungary’s experience with transitional justice and the rule of law as a shadow case to illustrate similar dynamics to those taking place in Poland.