bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous visual exploration during locomotion in patients with phobic postural vertigo
Authors: Penkava J. , Bardins S. , Brandt T. , Wuehr M. , Huppert D. 
Published: August 2020

Abstract
Background
Earlier studies on stance and gait with posturographic and EMG-recordings and automatic gait analysis in patients with phobic postural vertigo (PPV) or visual height intolerance (vHI) revealed similar patterns of body stiffening with muscle co-contraction and a slow, cautious gait. Visual exploration in vHI patients was characterized by a freezing of gaze-in-space when standing and reduced horizontal eye and head movements during locomotion.

Objective
Based on the findings in vHI patients, the current study was performed with a focus on visual control of locomotion in patients with PPV while walking along a crowded hospital hallway.

Methods
Twelve patients with PPV and eleven controls were recruited. Participants wore a mobile infrared video eye-tracking system that continuously measured eye-in-head movements in the horizontal and vertical planes and head orientation and motion in the yaw, pitch, and roll planes. Visual exploration behavior of participants was recorded at the individually preferred speed for a total walking distance of 200 m. Gaze-in-space directions were determined by combining eye-in-head and head-in-space orientation. Walking speeds were calculated based on the trial duration and the total distance traversed. Participants were asked to rate their feelings of discomfort during the walk on a 4-point numeric rating scale. The examiners rated the crowdedness of the hospital hallway on a 4-point numeric rating scale.

Results
The major results of visual exploration behavior in patients with PPV in comparison to healthy controls were: eye and head positions were directed more downward in the vertical plane towards the ground ahead with increased frequency of large amplitude vertical orientation movements towards the destination, the end of the ground straight ahead. The self-adjusted speed of locomotion was significantly lower in PPV. Particularly those patients that reported high levels of discomfort exhibited a specific visual exploration of their horizontal surroundings. The durations of fixating targets in the visual surroundings were significantly shorter as compared to controls.

Conclusion
Gaze control of locomotion in patients with PPV is characterized by a preferred deviation of gaze more downward and by horizontal explorations for suitable auxiliary means for potential postural support in order to prevent impending falls. These eye movements have shorter durations of fixation as compared to healthy controls and patients with vHI. Finally, the pathological alterations in eye–head coordination during locomotion correlate with a higher level of discomfort and anxiety about falling.
Muscle activity in asymmetric bench press among resistance-trained individuals
Authors: Saeterbakken Atle Hole , Solstad Tom Erik J. , Behm David G. , Stien Nicolay , Shaw Matthew Peter , Pedersen Helene , Andersen Vidar 
Published: August 2020

Abstract
Purpose
To determine the effects of asymmetric loads on muscle activity with the bench press.

Method
Seventeen resistance-trained men performed one familiarization session including testing one repetition maximum (1RM) and three 5 repetition maximum (RM) lifts; using symmetric loads, 5% asymmetric loads, and 10% asymmetric loads. The asymmetric loading (i.e., reduced load on one side) was calculated as 5% and 10% of the subject`s 1RM load. In the experimental session, the three conditions of 5RM were conducted with electromyographic activity from the pectoralis major, triceps brachii, biceps brachii, anterior deltoid, posterior deltoid, and external oblique on both sides of the body.

Results
On the loaded side, asymmetric loads reduced triceps brachii activation compared to symmetric loads, whereas the other muscles demonstrated similar muscle activity between the three conditions. On the de-loaded side, 10% asymmetry in loading resulted in lower pectoralis major, anterior deltoid, and biceps brachii activation compared to 5% asymmetric and symmetric loading. On the de-loaded side, only pectoralis major demonstrated lower muscle activation than symmetric loads. Furthermore, asymmetric loads increased external oblique activation on both sides compared to symmetric loads.

Conclusions
Asymmetric bench press loads reduced chest and shoulder muscle activity on the de-loaded side while maintaining the muscle activity for the loaded side. The authors recommend resistance-trained participants struggling with strength imbalances between sides, or activities require asymmetric force generation (i.e., alpine skiing or martial arts), to implement asymmetric training as a supplement to the traditional resistance training.
Preoperative identification of microvascular invasion in hepatocellular carcinoma by XGBoost and deep learning
Authors: Jiang Yi-Quan , Cao Su-E , Cao Shilei , Chen Jian-Ning , Wang Guo-Ying , Shi Wen-Qi , Deng Yi-Nan , Cheng Na , Ma Kai , Zeng Kai-Ning , Yan Xi-Jing , Yang Hao-Zhen , Huan Wen-Jing , Tang Wei-Min , Zheng Yefeng , Shao Chun-Kui , Wang Jin , Yang Yang , Chen Gui-Hua 
Published: August 2020

Abstract
Purpose
Microvascular invasion (MVI) is a valuable predictor of survival in hepatocellular carcinoma (HCC) patients. This study developed predictive models using eXtreme Gradient Boosting (XGBoost) and deep learning based on CT images to predict MVI preoperatively.

Methods
In total, 405 patients were included. A total of 7302 radiomic features and 17 radiological features were extracted by a radiomics feature extraction package and radiologists, respectively. We developed a XGBoost model based on radiomics features, radiological features and clinical variables and a three-dimensional convolutional neural network (3D-CNN) to predict MVI status. Next, we compared the efficacy of the two models.

Results
Of the 405 patients, 220 (54.3%) were MVI positive, and 185 (45.7%) were MVI negative. The areas under the receiver operating characteristic curves (AUROCs) of the Radiomics-Radiological-Clinical (RRC) Model and 3D-CNN Model in the training set were 0.952 (95% confidence interval (CI) 0.923–0.973) and 0.980 (95% CI 0.959–0.993), respectively (p = 0.14). The AUROCs of the RRC Model and 3D-CNN Model in the validation set were 0.887 (95% CI 0.797–0.947) and 0.906 (95% CI 0.821–0.960), respectively (p = 0.83). Based on the MVI status predicted by the RRC and 3D-CNN Models, the mean recurrence-free survival (RFS) was significantly better in the predicted MVI-negative group than that in the predicted MVI-positive group (RRC Model: 69.95 vs. 24.80 months, p < 0.001; 3D-CNN Model: 64.06 vs. 31.05 months, p = 0.027).

Conclusion
The RRC Model and 3D-CNN models showed considerable efficacy in identifying MVI preoperatively. These machine learning models may facilitate decision-making in HCC treatment but requires further validation.
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
Authors: Jakobsen Gunnhild , Engstrøm Morten , Hjermstad Marianne Jensen , Rosland Jan Henrik , Aass Nina , Albert Eva , Kaasa Stein , Fayers Peter , Klepstad Pål , Paulsen Ørnulf 
Published: August 2020

AbstractPurposeAlthough corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer.MethodsPatient-reported sleep was a predefined secondary outcome in a prospective, randomized, placebo-controlled, double-blind trial that evaluated the analgesic efficacy of corticosteroids in advanced cancer patients (18+), using opioids, and having pain ≥ 4 past 24 h (NRS 0–10). Patients were randomized to the methylprednisolone group with methylprednisolone 16 mg × 2/day or placebo for 7 days. The EORTC QLQ-C30 (0–100) and the Pittsburgh Sleep Quality Index questionnaire (PSQI) (0–21) were used to assess the impact of corticosteroids on sleep at baseline and at day 7.ResultsFifty patients were randomized of which 25 were analyzed in the intervention group and 22 in the control group. Mean age was 64 years, mean Karnofsky performance status was 67 (SD 13.3), 51% were female, and the mean oral daily morphine equivalent dose was 223 mg (SD 222.77). Mean QLQ-C30 sleep score at baseline was 29.0 (SD 36.7) in the methylprednisolone group and 24.2 (SD 27.6) in the placebo group. At day 7, there was no difference between the groups on QLQ-C30 sleep score (methylprednisolone 20.3 (SD 32.9); placebo 28.8 (SD 33.0),p = 0.173). PSQI showed similar results.ConclusionsMethylprednisolone 16 mg twice daily for 7 days had no impact on patient-reported sleep in this cohort of patients with advanced cancer.Trial registrationClinical trial information NCT00676936 (13.05.2008)
Does the crystal structure of vanadium nitrogenase contain a reaction intermediate? Evidence from quantum refinement
Authors: Cao Lili , Caldararu Octav , Ryde Ulf 
Published: August 2020

Abstract
Recently, a crystal structure of V-nitrogenase was presented, showing that one of the µ2 sulphide ions in the active site (S2B) is replaced by a lighter atom, suggested to be NH or NH2, i.e. representing a reaction intermediate. Moreover, a sulphur atom is found 7 Å from the S2B site, suggested to represent a storage site for this ion when it is displaced. We have re-evaluated this structure with quantum refinement, i.e. standard crystallographic refinement in which the empirical restraints (employed to ensure that the final structure makes chemical sense) are replaced by more accurate quantum–mechanical calculations. This allows us to test various interpretations of the structure, employing quantum–mechanical calculations to predict the ideal structure and to use crystallographic measures like the real-space Z-score and electron-density difference maps to decide which structure fits the crystallographic raw data best. We show that the structure contains an OH−-bound state, rather than an N2-derived reaction intermediate. Moreover, the structure shows dual conformations in the active site with ~ 14% undissociated S2B ligand, but the storage site seems to be fully occupied, weakening the suggestion that it represents a storage site for the dissociated ligand.

Graphic abstract
George Frankl: an undervalued voice in the history of autism
Authors: Muratori Filippo , Calderoni Sara , Bizzari Valeria 
Published: August 2020

AbstractThis paper aims to propose that the psychiatrist George Frankl had more than a marginal role in the early history of autism. Frankl’s conception of autism as characterized by a lack of affective language has influenced both Asperger and Kanner. First, this proposal is historically supported; second it is corroborated by Frankl’s unpublished manuscript on Autism. We found that Frankl’s perspective about autism was, and still can be, considered innovative for multiple reasons. Specifically, Frankl proposed that autism could cover a spectrum of conditions; that it is a state of mind that is not necessarily abnormal; and that it is a neurobiological condition, which primarily needs to be understood by others. Finally, Frankl’s concepts of affective contact and affective language are reconsidered with reference to contemporary neuropsychology from which autism emerges not as a higher-order cognitive deficit, but as a result of an impairment of primordial ability to process low level sensory, motor and perceptual information gained through experiencing other persons.
Thinking digital libraries for preservation as digital cultural heritage: by R to R4 facet of FAIR principles
Authors: Barbuti Nicola 
Published: August 2020

AbstractThe Art. 2 of the UE Council conclusions of 21 May 2014 on cultural heritage as a strategic resource for a sustainable Europe (2014/C 183/08) states: “Cultural heritage consists of the resources inherited from the past in all forms and aspects—tangible, intangible and digital (born digital and digitized), including monuments, sites, landscapes, skills, practices, knowledge and expressions of human creativity, as well as collections conserved and managed by public and private bodies such as museums, libraries and archives”. Starting from this assumption, we have to rethink digital and digitization as social and cultural expressions of the contemporary age. We need to rethink digital libraries produced by digitization as cultural entities and no longer as mere dataset for enhancing fruition of cultural heritage, by defining clear and homogeneous criteria to validate and certify them as memory and sources of knowledge for future generations. By expanding R: Re-usable of the FAIR Guiding Principles for scientific data management and stewardship into R4: Re-usable, Relevant, Reliable and Resilient, this paper aims to propose a more reflective approach to creation of descriptive metadata for managing digital resource of cultural heritage, which can guarantee their long term preservation.
Family Reunification Decision-Making in Dutch Family Foster Care: A Dual Perspective Approach
Authors: Teunissen Mirte S. L. , Goemans Anouk , van Holen Frank , Vanderfaeillie Johan , Nefs Harold T. , Pijnenburg Huub M. , Damen Harm , Vedder Paul H. 
Published: August 2020

Abstract
Background
An important responsibility of the child welfare system, is taking decisions on the reunification of children with their birth parents after the children have lived in foster families. We currently lack evidence-based knowledge to guide the reunification decision-making process.

Objective
The present study uses concept mapping as an exploratory method, to identify themes that seem to be used by two groups of professionals in their judgement and decision making on reunification.

Method
First, we consulted 78 foster care workers and studied 172 legal cases to examine criteria important for reunification. Next, unique criteria were grouped and rated by 35 foster care workers and also by 12 family judges separately. The data was analysed with multidimensional scaling and cluster analysis which resulted in a concept map for each group of professionals.

Results
Both foster care workers and family judges suggested the following themes in the reunification decision-making process: (a) birth parents’ functioning and parenting abilities, (b) birth parents’ acceptance of support, and (c) the child’s functioning, developmental needs and wishes. Besides parallel themes, both foster care workers and family judges also seem to consider unique themes.

Conclusions
The suggested similarities and differences between the two groups of professionals possibly reflect different professional frameworks. The foster care workers’ considerations seem to have an orientation towards permanency planning while the family judges’ considerations seem to be linked to the legal framework. Gaining insight in the perspective of different groups of professionals involved in the process of reunification, is a small but important step towards reaching consensus through discussion in order to achieve the optimal implementation of the decisions considered in the best interest of children’s future.
The role of advanced end-use technologies in long-term climate change mitigation: the interlinkage between primary bioenergy and energy end-use
Authors: Tsutsui Junichi , Yamamoto Hiromi , Sakamoto Shogo , Sugiyama Masahiro 
Published: August 2020

AbstractThe role of advanced end-use technologies has been investigated in multiple series of scenarios using an integrated assessment model BET-GLUE, which comprises an energy-economic module (BET) and a bioenergy-land-use module (GLUE). The scenarios consider different technology assumptions on the availability of bioenergy with carbon capture and storage (BECCS) and end-use efficiencies featuring electrification under a wide range of carbon price trajectories, which start at 1–690 USD/tCO2 in 2030, increase at 4.5%/year, and level off in 2100. This scenario design allows close examination of energy, economic, and environmental implications of different levels of policy stringency and carbon budgets. While improving end-use efficiencies consistently decrease policy costs for a wide range of carbon budgets, the value of BECCS availability in terms of cost reduction is crucial only in a limited range toward lower budgets. Constraints on BECCS, including those indirectly imposed by the limited bioenergy supply, also tend to narrow the lower range of attainable budget levels, indicating technological and economic challenges, although they may have an impact on reducing the total budget including land-use emissions. Overall, the advanced end-use efficiency has a significant effect on the required level of policy stringency for a given climate goal, so that it can compensate for the biomass constraints.
STRA-MI-VT (STereotactic RadioAblation by Multimodal Imaging for Ventricular Tachycardia): rationale and design of an Italian experimental prospective study
Authors: Carbucicchio C. , Jereczek-Fossa B. A. , Andreini D. , Catto V. , Piperno G. , Conte E. , Cattani F. , Rondi E. , Vigorito S. , Piccolo C. , Bonomi A. , Gorini A. , Pepa M. , Mushtaq S. , Fassini G. , Moltrasio M. , Tundo F. , Marvaso G. , Veglia F. , Orecchia R. , Tremoli E. , Tondo C. 
Published: August 2020

Abstract
Background
Ventricular tachycardia (VT) is a life-threatening condition, which usually implies the need of an implantable cardioverter defibrillator in combination with antiarrhythmic drugs and catheter ablation. Stereotactic body radiotherapy (SBRT) represents a common form of therapy in oncology, which has emerged as a well-tolerated and promising alternative option for the treatment of refractory VT in patients with structural heart disease.

Objective
In the STRA-MI-VT trial, we will investigate as primary endpoints safety and efficacy of SBRT for the treatment of recurrent VT in patients not eligible for catheter ablation. Secondary aim will be to evaluate SBRT effects on global mortality, changes in heart function, and in the quality of life during follow-up.

Methods
This is a spontaneous, prospective, experimental (phase Ib/II), open-label study (NCT04066517); 15 patients with structural heart disease and intractable VT will be enrolled within a 2-year period. Advanced multimodal cardiac imaging preceding chest CT-simulation will serve to elaborate the treatment plan on different linear accelerators with target and organs-at-risk definition. SBRT will consist in a single radioablation session of 25 Gy. Follow-up will last up to 12 months.

Conclusions
We test the hypothesis that SBRT reduces the VT burden in a safe and effective way, leading to an improvement in quality of life and survival. If the results will be favorable, radioablation will turn into a potential alternative option for selected patients with an indication to VT ablation, based on the opportunity to treat ventricular arrhythmogenic substrates in a convenient and less-invasive manner.
Effect of carboxymethyl cellulose on the flow behavior of lithium-ion battery anode slurries and the electrical as well as mechanical properties of corresponding dry layers
Authors: Gordon Ronald , Orias Raquel , Willenbacher Norbert 
Published: August 2020

AbstractWe present a holistic view on the role of polymeric binders in waterborne LiB anodes, including preparation and processing of wet slurries as well as microstructure, electrical conductivity and mechanical integrity of dry electrode layers. We focus on carboxymethyl cellulose (CMC), with respect to technical application the influence of soft, nano-particulate styrene–butadiene rubber (SBR) as secondary binder is also addressed. We discuss the influence of CMC concentration, molecular weight (Mw) and degree of substitution (DS) on flow behavior of anode slurries. Rheological data are not only relevant for processing, here we use them to characterize the adsorption of CMC on active material particles and dispersion of these particles in the slurry at technically relevant concentrations. The fraction of CMC adsorbed onto graphite particles increases with increasingMwand decreasing DS. Electrical conductivity increases withMw, i.e. with decreasing free polymer deteriorating conductive carbon black pathways. CMC does not contribute to the adhesion of electrode layers, irrespective ofMwor DS, technically feasible adhesion is inferred by SBR. Cohesive strength of anode layers, determined here for the first time under well-defined mechanical load, increases with increasingMwand decreasing DS, i.e. with increasing fraction of adsorbed CMC and corresponding improved particle dispersion. Strong cohesion and high electrical conductivity are correlated to an alignment of graphite particles as revealed by electron microscopy, presumably enabled by higher particle mobility in well-dispersed slurries. Accordingly, targeted choice of CMC is a valuable means to control processing, electrical conductivity and mechanical strength of LiB electrodes.
A nonlinear viscoelastic–viscoplastic model for adhesives
Authors: Chen Yi , Smith Lloyd V. 
Published: August 2020

AbstractWe consider the nonlinear viscoelastic–viscoplastic behavior of adhesives. We develop a one-dimensional nonlinear model by combining Schapery’s nonlinear single integral model and Perzyna’s viscoplastic model. The viscoplastic strain was solved iteratively using the von Mises yield criterion and nonlinear kinematic hardening. The combined viscoelastic–viscoplastic model was solved using Newton’s iteration and implemented into a finite element model. The model was calibrated using creep-recovery data from bulk adhesives and verified from the cyclic behavior of the bulk adhesives. The finite element model results agreed with experimental creep and cyclic responses, including recoverable and permanent strain after load removal. Although the contribution of the viscoplastic strain was small, both viscoplastic and viscoelastic components of strain response were required to describe the adhesive creep and cyclic response.
Carbon Nanosheets Synthesis in a Gliding Arc Reactor: On the Reaction Routes and Process Parameters
Authors: Ma Xintong , Li Sirui , Chaudhary Rohit , Hessel Volker , Gallucci Fausto 
Published: August 2020

AbstractNon-thermal plasma is a promising technology for high purity nanomaterial synthesis in a fast, flexible and controllable process. Gliding arc discharge, as one of the most efficient non-thermal plasmas, has been widely used in gas treatment but rarely studied for the nanomaterial synthesis. In this study, a comparison study for carbon nanosheets synthesis including toluene dissociation and graphite exfoliation was investigated in a 2D gliding arc reactor at atmospheric pressure. The effects of gas flow rate, precursor concentration and power input on the structures of carbon nanosheets produced through the two synthesis routes were explored and compared. Amorphous carbon nanosheets were produced in both approaches with a few crystalline structures formation in the case of toluene dissociation. The thickness of carbon nanosheets synthesized from graphite exfoliation was less than 3 nm, which was thinner and more uniform than that from toluene dissociation. The flow rate of carrier gas has direct influence on the morphology of carbon nanomaterials in the case of toluene dissociation. Carbon spheres were also produced along with nanosheets when the flow rate decreased from 2 to 0.5 L/min. However, in the case of graphite exfoliation, only carbon nanosheets were observed regardless of the change in flow rate of the carrier gas. The generated chemical species and plasma gas temperatures were measured and estimated for the mechanism study, respectively.