bluuebunny/crossref_metadata_2025_split huggingface dataset:
A magnetar parallax
Authors: Ding H , Deller A T , Lower M E , Flynn C , Chatterjee S , Brisken W , Hurley-Walker N , Camilo F , Sarkissian J , Gupta V 
Published: August 2020

ABSTRACT
XTE J1810−197 (J1810) was the first magnetar identified to emit radio pulses, and has been extensively studied during a radio-bright phase in 2003–2008. It is estimated to be relatively nearby compared to other Galactic magnetars, and provides a useful prototype for the physics of high magnetic fields, magnetar velocities, and the plausible connection to extragalactic fast radio bursts. Upon the rebrightening of the magnetar at radio wavelengths in late 2018, we resumed an astrometric campaign on J1810 with the Very Long Baseline Array, and sampled 14 new positions of J1810 over 1.3 yr. The phase calibration for the new observations was performed with two-phase calibrators that are quasi-colinear on the sky with J1810, enabling substantial improvement of the resultant astrometric precision. Combining our new observations with two archival observations from 2006, we have refined the proper motion and reference position of the magnetar and have measured its annual geometric parallax, the first such measurement for a magnetar. The parallax of 0.40 ± 0.05 mas corresponds to a most probable distance $2.5^{\, +0.4}_{\, -0.3}$ kpc for J1810. Our new astrometric results confirm an unremarkable transverse peculiar velocity of ≈200 $\rm km~s^{-1}$ for J1810, which is only at the average level among the pulsar population. The magnetar proper motion vector points back to the central region of a supernova remnant (SNR) at a compatible distance at ≈70 kyr ago, but a direct association is disfavoured by the estimated SNR age of ∼3 kyr.
The impact of tidal disruption events on galactic habitability
Authors: Pacetti E , Balbi A , Lingam M , Tombesi F , Perlman E 
Published: August 2020

ABSTRACTTidal disruption events (TDEs) are characterized by the emission of a short burst of high-energy radiation. We analyse the cumulative impact of TDEs on galactic habitability using the Milky Way as a proxy. We show that X-rays and extreme ultraviolet radiation emitted during TDEs can cause hydrodynamic escape and instigate biological damage. By taking the appropriate variables into consideration, such as the efficiency of atmospheric escape and distance from the Galactic centre, we demonstrate that the impact of TDEs on galactic habitability is comparable to that of active galactic nuclei. In particular, we show that planets within distances of ∼0.1–1 kpc could lose Earth-like atmospheres over the age of the Earth, and that some of them might be subject to biological damage once every ≳ 104 yr. We conclude by highlighting potential ramifications of TDEs and argue that they should be factored into future analyses of inner galactic habitability.
Compressing combined probes: redshift weights for joint lensing and clustering analyses
Authors: Ruggeri Rossana , Blake Chris 
Published: August 2020

ABSTRACT
Combining different observational probes, such as galaxy clustering and weak lensing, is a promising technique for unveiling the physics of the Universe with upcoming dark energy experiments. Whilst this strategy significantly improves parameter constraints, decreasing the degeneracies of individual analyses and controlling the systematics, processing data from tens of millions of galaxies is not a trivial task. In this work, we derive and test a new compressed statistic for joint clustering and lensing data analysis, maximizing the scientific return and decreasing the computational cost. Our approach compresses the data by up-weighting the components most sensitive to the parameters of interest, with no loss of information, taking into account information from the cross-correlation between the two probes. We derive optimal redshift weights which may be applied to individual galaxies when testing a given statistic and cosmological model.
Two close binaries across the hydrogen-burning limit in the Praesepe open cluster
Authors: Lodieu N , del Burgo C , Manjavacas E , Zapatero Osorio M R , Alvarez C , Béjar V J S , Boudreault S , Lyke J , Rebolo R , Chinchilla P 
Published: August 2020

ABSTRACT
We present Keck I/OSIRIS and Keck II/NIRC2 adaptive optics imaging of two member candidates of the Praesepe stellar cluster (d  =  186.18 ± 0.11 pc; 590–790 Myr), UGCS J08451066+2148171 (L1.5 ± 0.5) and UGCS J08301935+2003293 (no spectroscopic classification). We resolved UGCS J08451066+2148171 into a binary system in the near-infrared, with a K-band wavelength flux ratio of 0.89 ± 0.04 and a projected separation of 60.3 ± 1.3 mas (11.2 ± 0.7 au; 1σ). We also resolved UGCS J08301935+2003293 into a binary system with a flux ratio of 0.46 ± 0.03 and a separation of 62.5 ± 0.9 mas. Assuming zero eccentricity, we estimate minimum orbital periods of ∼100 yr for both systems. According to theoretical evolutionary models, we derive masses in the range of 0.074–0.078 and 0.072–0.076 M⊙ for the primary and secondary of UGCS J08451066+2148171 for an age of 700 ± 100 Myr. In the case of UGCS J08301935+2003293, the primary is a low-mass star at the stellar/substellar boundary (0.070–0.078 M⊙), while the companion candidate might be a brown dwarf (0.051–0.065 M⊙). These are the first two binaries composed of L dwarfs in Praesepe. They are benchmark systems to derive the location of the substellar limit at the age and metallicity of Praesepe, determine the age of the cluster based on the lithium depletion boundary test, derive dynamical masses, and improve low-mass stellar and substellar evolutionary models at a well-known age and metallicity.
7 Understanding Regional Site Transfer: Perceptions of Health Care Professionals
Authors: Bele Sumedh , Bailey J A Michelle , Randhawa Alam 
Published: August 2020

Abstract

Background
Alberta Health Services identified that tertiary sites are often in overcapacity (admitted patients exceeding inpatient beds) while regional sites have low occupancy in their pediatric inpatient units. Hospital overcapacity may have negative effects on the care received by patients, such as increased risk of infection, less time spent with each patient and increased stress on the hospital staff (Keegan, 2010). In addition, rural families face several barriers to access to health care including traveling long distances to access the sub-specialty care present in urban tertiary centers. Previous studies conducted by our team found that transfers back to regional sites are not common. Increasing transfers of pediatric patients from tertiary to regional sites with care supported by the tertiary site could aid in addressing tertiary overcapacity and enable patients and families to receive care closer to home.

Objectives
This qualitative study sought to understand tertiary site health care professionals’ perceptions of tertiary to regional inpatient transfer.

Design/Methods
Four semi-structured focus groups were held with health care professionals. Focus groups included a mixed group of staff physicians, residents, nurses and managers. Common themes of discussion included the current transfer process, understanding of regional site resources and ways to increase patient transfer. A qualitative data analysis software, NVivo 11, was used to code, organize, and manage the data to facilitate data interpretations and generate themes regarding the current patient transfer process.

Results
The main barriers of pediatric transfer to rural sites include a lack of standardized transfer guidelines, limited understanding of rural regional site resources and mistrust between medical teams that prohibit patient transfer. The most likely pediatric patients that could be transferred back to rural sites include clearly diagnosed, single body system patients. Participants who had previous experience working in regional sites were more comfortable with transfer to regional sites. Transfer to regional sites could be increased by improving communication between medical teams and correcting misinformation about regional inpatient pediatric sites.

Conclusion
There is a historical practice of concentrating resources at tertiary care sites. However, there are a lack of shared guidelines for transfer as well as well as limited knowledge of regional site capabilities. Health care professionals across the entire continuum of patient care recognize the need to find solutions that would aid in transfer.
21 Communicating Sensitive Information - An Exploration of Parental Perspectives on Prognostication of High Risk Infants
Authors: Fong Emily 
Published: August 2020

Abstract

Background
Preterm infants are at high risk of experiencing a range of impairments that may contribute to long-term challenges such as neurocognitive deficits. Physicians are often expected to give an outlook on future developmental outcomes of high risk infants, often before sufficient time has elapsed to observe whether that particular child will demonstrate neurologic recovery from the initial injury. Clinicians often struggle with communicating this information, especially a poor prognosis because of the worry about how these conversations affect families and their future expectations of the child.

Objectives
Our aim was to capture parents’ retrospective perception of how their infant’s prognosis was communicated to them during their NICU stay.

Design/Methods
Semi-structured interviews were conducted over the phone with parents of former preterm infants with a birthweight below 1500 grams or parents of term infants who have sustained HIE requiring cooling. Parents were invited to participate when their child was between 12-36 months old at the time of the interview, so that parents would be able to have a sense of their child’s development and possible impairments. The data was analyzed thematically, with particular focus around the discourse of communication and prognostication.

Results
Twenty-three interviews were conducted, 20 with the biological mother, 2 with both biological parents, and 1 with the biological father. The average length of the interviews was 30 minutes. The main themes that recurred in the interviews include parental loss of control, needing to prepare for the unexpected, the value of shared decision making between the health care practitioners and parents, recognition and conveyance of uncertainty by the physician, and the importance of celebrating the present. Above all, a recurring theme mentioned by the majority of interviewees was the power of hope. While wanting to receive transparent and honest updates, parents felt strongly that giving them realistic hope was of utmost importance.

Conclusion
Although clinicians often feel pressured to deliver answers, parents found it helpful when clinicians acknowledged and explained the uncertainty that surrounds prognostication. While healthcare providers may feel the need to prepare parents for the worst, the importance of balancing this information with hope and positivity is what families remember and value years after the prognosis was given.
26 Not What Clinicians Thought: Decisional Regret in Parents of Extremely Preterm Children
Authors: Thivierge Emilie , Duquette Laurie-Anne , Mai-Vo Thuy-An , Fortin Aurélie , Jaworski Magdalena , Bourque Claude Julie , Pearce Rebecca , Luu Thuy Mai , Janvier Annie 
Published: August 2020

Abstract

Background
Preterm birth is associated with higher risk of death and severe neurodevelopmental impairment. There is an increased risk in extremely preterm infants, raising questions among ethicists and clinicians as to whether providing active care to infants born at the lower extreme is worth the outcomes, and if these outcomes are a source of decisional regrets for parents.

Objectives
Explore decisional regrets in parents of extremely preterm children.

Design/Methods
We consecutively recruited all parents of infants born &lt;29 weeks’ gestational age, aged between 18 months corrected age and 7 years, and seen for neonatal follow-up at a single tertiary center over a one-year period. We asked the following question: “Knowing what you know now, is there anything you would have done differently?” Answers were analyzed independently by two reviewers using qualitative methodology, and discrepancies were resolved by a third reviewer. Mixed methods were used to examine the frequency of each theme and associate parental answers to demographic and clinical factors.

Results
Responses were obtained from 249 parents (98% participation rate). The following main themes emerged: (1) Nothing – I did what I could or was told to do: 53%; (2) Regrets about self-care: 31%; “I would listen to the nurses’ advice to sleep more” (3) Guilt related to the impression preterm labor could have been prevented by them or the medical team: 19%; “I would have pushed for better care and monitoring during pregnancy. I felt as though I wasn’t listened to when I thought I was in labour when sure enough I was” (4) Regrets about parental role in decision-making: 15%; “I would speak up more at the beginning of the hospitalisation”. None of the parents reported on regretting any life-and-death decisions they made at birth and in the neonatal unit.

Conclusion
In our cohort, more than half of parents of surviving preterm infants did not have any regrets associated to their NICU experience. However, lessons can be learned to improve parental support, self-care and solutions to improve their role as parents. Unlike what can be stated using “opinion-based medicine”, limiting or forgoing intensive care is not a solution to eliminate decisional regrets in parents.
34 Newborn Jaundice Screening Nomogram for Universal Screening in Saskatchewan
Authors: Baerg Krista , Smith-Fehr Julie , Lee Chel 
Published: August 2020

Abstract

Background
Transcutaneous (TcB) meters support clinical decision making at point-of-care, reduces nurses’ time to screen, decreases the frequency of painful blood draws and minimizes health care costs. Best practice for TcB screening is unknown and international guidelines vary. Meter bias may result in over- or underestimation of TSB in a Canadian population. The Canadian Paediatric Society suggests screening between 24 and by 72 hours of age and reducing total serum bilirubin (TSB) action thresholds by the 95th confidence interval of the meter. To support point-of-care decision making, a tertiary center and community follow-up program uses universal screening and follow-up protocols. ​

Objectives
The aim of this analysis is to develop a locally validated TcB nomogram with action thresholds based on age and risk for clinical use at point-of-care. ​

Design/Methods
This prospective cross-sectional study includes newborns ≥35 weeks gestation &lt;14 days old requiring TSB sampling in hospital or community and 13 JM-105 meters. Participants are included if TcB reading ranges from 1-340µmol/L (0.1-20.0 mg/dL) and TSB is collected within 1 hour of TcB measurement. TSB samples are analyzed using Roche™ Bilirubin Total Gen.3. To measure how close the TcB reading is to TSB, the difference is found by subtracting TSB from mean TcB. Lin’s Concordance statistics are calculated for each meter. Using a 2-dimentional 95th Confidence Interval ellipse, we select 13 JM-105 meters with similar accuracy and precision for use by the universal screening program. Using a quadratic model we fit a line based on the lower 95th predictive interval of the grouped meter data collected from 13 meters to Canadian Paediatric Society low, medium and high risk TSB thresholds for intensive phototherapy. ​

Results
The study population includes 498 newborns that received 620 visits and 705 meter readings with thirteen JM-105 with mean birth weight 3.38 kilograms (SD=0.51) with thirteen JM-105. Along with the clinical screening protocol, nomograms for newborns 35-37 weeks gestation (high and medium risk thresholds) and 38+ weeks gestation medium and low risk thresholds) are presented. Newborns with TcB that plots in a potential treatment range will receive a TSB to determine if intensive phototherapy is required.

Conclusion
To support point-of-care decision making, a tertiary center and community follow-up program uses universal screening and follow-up protocols. TcB nomograms with action thresholds based on age and risk support point-of-care decision making.
41 Fostering Hope: The Comprehensive Accessible care for Infants with Neonatal abstinence (CAIN) Study
Authors: Clarke Denise , Hicks Matt , Foss Karen , Lifeso Natasha 
Published: August 2020

Abstract

Introduction/Background
Neonatal Abstinence Syndrome (NAS) occurs in newborns exposed to drugs in-utero. In Canada, maternal opiate use in pregnancy has been steadily rising resulting in as many as 1850 babies born with NAS per year. Management of babies born with NAS requires supportive, interdisciplinary care. Depending on the severity of NAS, babies may be cared for with non-pharmacological interventions or some may need to be admitted to the Neonatal Intensive Care Unit for extended hospital stays to receive medication and management of ongoing complex health care needs. Hospital and community health care providers have expressed concerns around the continuity of care for these babies in their stay in hospital and their transition to home.

Objectives
This study examined the experiences of hospital and community-based health care providers and families regarding the management of babies with NAS. The driving force behind our inquiry related to our interest in streamlining care for these babies in highly complex health and social systems.

Design/Methods
In total, 47 interdisciplinary participants were interviewed over a four-month period with individuals from Women’s and Child Health, Community, and family members. Interviewed transcripts were reviewed over several months and were completed in December 2019 using an inductive thematic analysis which culminated in the identification of an overarching theme linked with primary themes. ​

Results
The study identified existing gaps in the management of these patients, determined how to improve communication between hospital and community networks, and provided a better understanding of the attitudes, perceptions and experiences of hospital and community personnel. The overarching theme identified was hope, with the primary themes being: system, mental health, mother/baby, judgement, and knowledge (see Figure 1). Several gaps identified in the system included fear, stigma, and language. Certain solutions proposed for improvement included focused care in a rooming in model for the mother and baby dyad, supporting mothers’ well-being, involving mothers and families, and supporting care providers in a family centered care model. In Figure 1, green lines indicate themes that are linked with and support hope, and red lines indicate themes that are barriers to hope.

Conclusion
This research demonstrates that programs and interventions implemented when working with mothers and babies with NAS must foster hope in mothers, families, and in the extended care provider team.
60 Precision Medicine in Developmental Pediatrics: Image-based Classification of Children with Autism Spectrum Disorder using Deep Learning
Authors: MacEachern Sarah , Rajashekar Deepthi , Mouches Pauline , Rowe Nathan , Mckenna Emily , Yeom Kristen , Forkert Nils Daniel 
Published: August 2020

Abstract

Introduction/Background
Autism spectrum disorder (ASD) is a neurodevelopmental disorder resulting in challenges with social communication, sensory differences, and repetitive and restricted patterns of behavior. ASD affects approximately 1 in 66 children in North America, with boys being affected four times more frequently than girls. Currently, diagnosis is made primarily based on clinical features and no robust biomarker for ASD diagnosis has been identified. Potential image-based biomarkers to aid ASD diagnosis may include structural properties of deep gray matter regions in the brain.

Objectives
The primary objective of this work was to investigate if children with ASD show micro- and macrostructural alterations in deep gray matter structures compared to neurotypical children, and if these biomarkers can be used for an automatic ASD classification using deep learning.

Design/Methods
Quantitative apparent diffusion coefficient (ADC) magnetic resonance imaging data was obtained from 23 boys with ASD ages 0.8 – 19.6 years (mean 7.6 years) and 39 neurotypical boys ages 0.3 – 17.75 years (mean 7.6 years). An atlas-based method was used for volumetric analysis and extraction of median ADC values for each subject within the cerebral cortex, hippocampus, thalamus, caudate, putamen, globus pallidus, amygdala, and nucleus accumbens. The extracted quantitative regional volumetric and median ADC values were then used for the development and evaluation of an automatic classification method using an artificial neural network.

Results
The classification model was evaluated using 10-fold cross validation resulting in an overall accuracy of 76%, which is considerably better than chance level (62%). Specifically, 33 neurotypical boys were correctly classified, whereas 6 neurotypical boys were incorrectly classified. For the ASD group, 14 boys were correctly classified, while 9 boys were incorrectly classified. This translates to a precision of 70% for the children with ASD and 79% for neurotypical boys.

Conclusion
To the best of our knowledge, this is the first method to classify children with ASD using micro- and macrostructural properties of deep gray matter structures in the brain. The first results of the proposed deep learning method to identify children with ASD using image-based biomarkers are promising and could serve as the platform to create a more accurate and robust deep learning model for clinical application.