bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of insecticide resistance in Aedes aegypti: meta‐analyses of surveys in Latin America and the Caribbean
Authors: Guedes Raul Narciso C , Beins Kaley , Navarro Costa Dennis , Coelho Giovanini E , Bezerra Haroldo Sérgio da S 
Published: January 2020

AbstractBACKGROUNDThe re‐emergence of worldwide concern with arthropod‐borne viruses (arboviruses) draws increasing attention to their mosquito vectors, particularly Aedes aegypti, whose control heavily rely on insecticide use. As a consequence, insecticide resistance is frequent, but the general patterns of occurrence, cross‐resistance and prevailing mechanisms remain unrecognized in some areas such as the Neotropical region. Thus, we sought here to recognize the general trends and patterns of insecticide resistance in Latin America and the Caribbean. A systematic literature review (2008–2018) aimed the data‐gathering for the region and meta‐analyses to address the stated knowledge gap.RESULTSA high incidence of insecticide resistance prevails in the mosquito populations of the region. Dichlorodiphenyltrichloroethane (DDT), temephos and deltamethrin were the main insecticides evaluated and the meta‐analyses indicate a high frequency of DDT‐resistant populations (86.7 ± 0.1%), followed by temephos (75.7 ± 0.1%) and deltamethrin (33.0 ± 0.1%). No evidence of cross‐resistance was detected among these three insecticides, and the V1016I knockdown (KDR) site mutation does not explain the patterns of deltamethrin resistance in the region.CONCLUSIONResistance to DDT, temephos and deltamethrin is serious and widespread, and there is no cross‐resistance among them. Altered target site sensitivity is not the main pyrethroid resistance mechanism, which is likely due to a mix of mechanisms. Therefore, the replacement of deltamethrin and particularly temephos in the region by alternative insecticides is an important resistance management recommendation, but should be done with compounds out of the cross‐resistance spectrum for these populations and insecticides. Nonetheless, the non‐recognition of the prevalent resistance mechanisms in the region makes this suggestion more difficult to apply and invites more broad‐scale studies of resistance mechanisms to fill this knowledge gap and improve the resistance management recommendations. © 2020 Society of Chemical Industry
Comparing the lens displacement profile data by using the sequential approach for selecting alternative suppliers
Authors: Lin Chen‐ju , Chuang Yuan‐chung 
Published: January 2020

AbstractThe lens module is a critical part of the camera module. The quality of the lens module significantly influences the auto‐focus and image stability functions of the camera module. A new approach that uses sequential tests is proposed to select the alternative suppliers that provide the qualified parts as the current supplier under the linear profile data. Having several qualified alternative suppliers can reduce the dependency on one supplier, improve bargaining power, and reduce capacity risk. The lens displacement that has a linear relationship with current is the quality characteristic for evaluating the lens module suppliers. To select the qualified alternative suppliers, the proposed sequential approach tests the profile difference between the current supplier and the investigated suppliers. The simulation results show that the power of the sequential approach is higher than the simultaneous confidence bands method in differentiating profiles. Last, the proposed approach is effectively applied to select the qualified alternative lens module suppliers for the camera module manufacturer. Procuring the lens module from the selected suppliers can maintain production quality and flexibility for the camera module manufacturer in practice.
1,4‐Disubstituted‐1,2,3‐triazole GABA Analogues: Synthesis, In Vitro Evaluation, Quantum QSAR and Molecular Docking against Pseudomonas fluorescens GABA‐AT
Authors: Díaz‐Peralta Lucero , Razo‐Hernández Rodrigo Said , Pastor Nina , Santiago Ángel , Guevara‐Salazar Juan Alberto , Fernández‐Zertuche Mario 
Published: January 2020

AbstractWe report the synthesis of a new series of γ‐aminobutyric acid (GABA) analogues where the nitrogen at the ɣ‐position is contained in a 1,4‐disubstituted‐1,2,3‐triazole ring system. The triazole ring system was assembled by the Cu(I)‐catalyzed alkyne‐azide 1,3‐dipolar cycloaddition (CuACC) protocol. We have identified two active compounds with 43 and 59 % inhibition respectively. A descriptive quantum QSAR study was carried out to correlate this activity with the structural changes in the GABA scaffold. The inhibitory activity of the compounds is related to the electronic properties of the triazole ring and substituents. The interaction with P. fluorescens GABA‐aminotransferase (GABA‐AT) was evaluated by molecular docking, using a homology model of the biological target. One compound showed the best interaction energy, the thiophene‐ substituted triazole 26 c, with a value that correlates well with the experimental inhibition results. The triazole ring is determinant for a proper orientation for interaction with the GABA‐AT enzyme. In addition, the molecular docking revealed the importance of a hydrophobic pocket near the PLP prosthetic group and how this pocket can be used to improve the inhibitory activity of GABA analogues. Human GABA‐AT molecular docking studies of these analogues showed their great potential as competitive inhibitors of this enzyme.
Synthesis and Properties of a Silicon‐Containing Arylacetylene Resin with 2,6‐Diphenoxypyridine Unit
Authors: Ma Manping , Li Chuan , Liu Xiaotian , Yuan Qiaolong , Huang Farong 
Published: January 2020

AbstractA novel silicon‐containing arylacetylene resin called poly(dimethylsilylene‐ethylene‐phenoxypyridyloxy‐phenylene‐ethylene) (PSPPY) was made from 2,6‐bis(4‐ethynyl‐phenoxy) pyridine and dimethyldichlorosilane by Grignard reactions. The structure and properties of the resin were characterized by 1H‐NMR, FT‐IR, GPC, XRD, DSC, TGA and universal testing machine. The resin has a wide processing window ranged from 35 °C to 155 °C. The cured resin shows excellent mechanical property, low dielectric property and high thermal stability. The flexural strength of the cured resin at room temperature reaches 58.7 MPa. The cured resin has dielectric constant 3.0–3.5, dielectric loss 0.008‐0.040 in the frequency of 10−1‐106 Hz, and low water uptake (0.8 %). The degradation temperature at 5 % weight loss and the residue at 800 °C of the cured resin arrive at 500 °C and 77.1 % in nitrogen atmosphere, respectively.
Bimetallic Pd‐Sn Nanocatalysts for Selective Synthesis of Amines and Imines in Water
Authors: Mukhi Priyabrata , Roy Sujit 
Published: January 2020

AbstractAided by our interest in green chemistry, we report the synthesis of a novel Pd‐Sn nano catalyst for C−N coupling reaction in water. The catalyst has been synthesized by a simple wet chemical reduction method and fully characterized by a library of physico‐chemical techniques such as Powder X‐Ray Diffraction (PXRD), High Resolution Transmission Electron Microscopy (HRTEM), X‐Ray Photo Electron Spectroscopy (XPS) and UV‐Vis spectroscopy, Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X‐Ray (EDX) spectroscopy, and Inductively Coupled Plasma Optical Emission Spectroscopy (ICP‐OES). The robust Pd‐Sn catalyst shows high catalytic efficiency for the oxidative coupling of benzylamines and tandem coupling between alcohol and amine in water as solvent to give rise to the corresponding secondary amines. However, in presence of oxygen both the reactions stop at the imine stage. As a result, we could guide the reaction to obtain selectively amine or imine. The high efficiency, recyclability and good substrate scope of this Pd‐Sn nanocatalyst is noteworthy. Preliminary mechanistic studies indicated that the reactions proceed via initial activation of N−H bond of amine
Effect of Hexadecylpyridinium Bromide (HDPB) on Morphology and Electrocatalytic Performance of Porous Palladium Nanoparticles
Authors: Cui Zelin , Bai Xuefeng , Liu Teng 
Published: January 2020

AbstractStructure‐controlled synthesis of palladium nanoparticles has long been a hot subject because of their remarkable catalytic performance. Herein, hexadecylpyridinium bromide (HDPB) was introduced as capping agent in the preparation of Pd nanoparticles (PdNPs) through a facile none‐seeded routine using Na2PdCl4 as precursor. The as‐prepared PdNPs was in the shape of flocculus and it had a highly porous feature with an average size of 53.1 nm. The morphology evolution along with time was investigated by transmission electron microscopy and a possible formation mechanism of PdNPs was proposed. Meanwhile, the structural changes of PdNPs along with the concentration of HDPB and temperature were also studied. The relationship between structure and electrocatalytic activity were discussed. The electrocatalytic performance of PdNPs was much superior than commercial Pd/C toward methanol electro‐oxidation in the alkaline medium. The optimum electrocatalytic activity (jf=19.4 mA cm−2) was obtained catalyzing by PdNPs synthesized when n(HDPB)/n(Pd2+)=0.6 : 1 at 50°C for 3 h.
Zinc‐Catalysed Multi‐Component Reactions: An Overview
Authors: Neetha Mohan , Rohit K. R. , Saranya Salim , Anilkumar Gopinathan 
Published: January 2020

AbstractMulti‐component reactions (MCRs) have gathered much attention recently due to their superior efficiency, exceptional selectivity and simplicity. Synthesis of various compounds with maximum efficiency and almost zero by‐products are their major highlights. Zinc is an easily accessible, economically feasible and environmentally viable catalyst. This first review in this topic focuses on the developments in zinc‐catalysed multi‐component reactions and covers literature up to 2019.
Morphological Influence of TiO2 Nanostructures on Charge Transfer and Tetracycline Degradation Under LED Light
Authors: Moshoeu Dimakatso E. , Sanni Saheed O. , Oseghe Ekemena O. , Msagati Titus A. M. , Mamba Bhekie B. , Ofomaja Augustine E. 
Published: January 2020

AbstractIn this study, TiO2 nanostructured materials (nanotube (T‐NT), nanofiber (T‐NF) and nanosphere (T‐NS)) were prepared via the hydrothermal method, characterized, and comparatively tested for surface OH density, charge mobility and in the photocatalytic degradation of tetracycline (TC). Results from the N2 sorption experiment and the pore size distribution shows that the materials are mesoporous with good Brunauer–Emmett–Teller (BET) surface area ranging from 127–274 m2/g and pore volume. T‐NF exhibited the best photocatalytic performance having a rate constant 0.0025 Lmg−1 min−1, which is 1.6, 5 and 6.3 times higher than T‐NT, T‐NS, and amorphous TiO2 (T‐AM) respectively. The outstanding performance of T‐NF over the other materials is due to its relatively low charge transfer, higher crystallinity, and higher surface OH density which reacts with h+ to form OH•.
Design and Synthesis of a Class of Compounds That Inhibit the Growth of Fungi Which Cause Invasive Infections
Authors: Nakada‐Motokawa Nana , Miyazaki Taiga , Mizuta Satoshi , Tanaka Yoshimasa , Hirayama Tatsuro , Takazono Takahiro , Saijo Tomomi , Yamamoto Kazuko , Imamura Yoshifumi , Izumikawa Koichi , Yanagihara Katsunori , Makimura Koichi , Takeda Kohsuke , Kohno Shigeru , Mukae Hiroshi 
Published: January 2020

AbstractInvasive fungal infections are growing causes of morbidity and mortality in immunocompromised patients. However, only one antifungal drug class has been developed in the last 30 years, extremely limiting current therapeutic options. To address unmet medical needs, we performed high‐throughput screening of 9600 chemical compounds and identified an aminohydrazone derivative as a novel and potent antifungal compound. We then designed and synthesized a series of aminohydrazone derivatives, and demonstrated that 1‐[(E)‐[4‐(3′,4′‐dichlorobenxyloxy)phenyl methylidene]amino]‐guanidine had the most potent inhibitory activity and exhibited a broad spectrum of antifungal activities against Candida species (including multidrug resistant C. auris), Aspergillus species, Cryptococcus neoformans, and Rhizopus oryzae. Against C. albicans, the leading cause of Candida infections, the compound had fungicidal activity for planktonic cells at 8 μg mL−1 (25 μM) and anti‐biofilm activity at 34 μg mL−1 (100 μM). This study provides new insights for the development of a new drug class for the treatment of invasive fungal infections which are often refractory to conventional therapies.
Highly Efficient Catalysts for Conversion of CO2 into Cyclic Carbonates Based on the Ternary Layered ZIF‐8/P4VP/Au Hybrids
Authors: Fu Congcong , Zhang Yue , Ma Yehui , He Jiahui , Ge Kai , Li Zhenxing , Ye Jin , Zhou Xuejian , Wang Shuang , Yang Kai , Yang Yongfang 
Published: January 2020

AbstractThe P4VP with the molecular weight of 12 K and the molecular weight distribution of 1.2 was synthesized via reversible addition‐fragmentation chain transfer polymerization. Then it was added to the system for the preparation of ZIF‐8 as a surfactant. A special two‐dimensional (2D) sheet was produced because P4VP could promote the lateral growth of ZIF‐8. Additionally, the pyridine group from P4VP chains could complex Au3+ followed by in‐situ reduction under UV light to form the 2D ZIF‐8/P4VP/Au ternary hybrids. The ternary layered ZIF‐8/P4VP/Au hybrids exhibited a good yield for epoxy carbonate of 71 % and the high time‐space yield of 3.22 h−1 in the reaction of carbon dioxide with propylene oxide, which was much higher than 0.425 h−1 of the conventional homogeneous catalyst KI. Besides, the ternary layered ZIF‐8/P4VP/Au showed good stability, the catalytic performance was unchanged after three cycles.
Blueberry‐Peel‐Derived Porous Carbon for High‐Performance Supercapacitors: The Effect of N‐Doping and Activation
Authors: Zhong Yuan , Li Qin , Liu Rui 
Published: January 2020

AbstractNitrogen‐doped (N‐doped) activated porous carbon has been successfully prepared, using blueberry peel (BP) as a carbon source and melamine as a nitrogen source through a simple and effective carbonization and activation process. The obtained ABP‐1.5‐700 (ABP‐x‐y, ABP: blueberry peel derived activated porous carbon; x: BP/melamine mass ratio; y: carbonization temperature), with a nitrogen doping content of 8.29 at % presented a maximum specific capacitance of 324.3 F g−1 at a current density of 1 A g−1 in 6 M potassium hydroxide (KOH) aqueous electrolyte. It also showed an excellent cycle stability about 99.9% retention after 20000 charge‐discharge cycles. The assembled ABP‐1.5‐700‐based symmetric capacitor displayed the value of the specific capacitance was 75 F g−1 at 1 A g−1 with a maximum energy density of 13.78 Wh kg−1 and a power density of 661.25 W kg−1 (0‐1.15 V) in 6 M KOH electrolyte solution. The results showed that the porous carbon derived from blueberry peel presented a good potential for high performance supercapacitors.
Formation of N,S‐Containing Polycycles via Base Promoted Dimerization of N‐Phenacyl and N‐Benzylbenzothiazolium Bromides
Authors: Ding Bang‐Dong , Sun Jing , Jiang Wang , Jin Gong , Yan Chao‐Guo 
Published: January 2020

AbstractThe triethylamine promoted dimerization of N‐phenacylbenzothiazolium bromides in ethanol resulted in a mixture of N,O,S‐containing six fused‐cyclic compounds and N,S‐containing five fused‐cyclic compounds in moderate yields. On the other hand, the base promoted dimerization of N‐benzylbenzothiazolium bromides selectively afforded 2,3‐bis(4‐methylbenzyl)‐2,3‐dihydro‐2,2′‐bibenzo[d]thiazoles or 3,3′‐bis(4‐methoxybenzyl)‐2,2′‐spirobi[benzo[d]thiazoles] depending on the electronic effect of the substituents on the benzyl group. The plausible formation mechanisms of the various annulation products were rationally proposed.
More habitual physical activity is linked to the use of specific, more adaptive cognitive reappraisal strategies in dealing with stressful events
Authors: Perchtold‐Stefan Corinna M. , Fink Andreas , Rominger Christian , Weiss Elisabeth M. , Papousek Ilona 
Published: January 2020

AbstractPhysical activity may improve stress resilience and well‐being. However, specific links to individuals' coping abilities with stressful events are sparse. This study tested whether individuals reporting more physical activity in daily life showed a higher capacity for cognitive reappraisal in dealing with potential stressors. Ninety‐eight participants reported their regular physical activity in the Freiburger Questionnaire on Physical Activity and completed a maximum performance test of their inventiveness in generating reappraisals for situations depicting real‐life stressors. The latter provides scores for overall cognitive reappraisal capacity (quantity of ideas) and preference for specific cognitive reappraisal strategies (quality of ideas; positive reinterpretation; problem‐oriented, de‐emphasizing reappraisals). Additionally, participants' anxious and depressive dispositions and general creative abilities were assessed. Results showed no association between time spent on physical activities per week and total quantity of generated reappraisal ideas. However, a higher degree of physical activity was specifically linked to a greater relative preference for the reappraisal strategy of positive reinterpretation. Opposite associations emerged for the strategy of de‐emphasizing reappraisals. The findings support the notion of more adaptive cognitive reappraisal use in more physically active individuals and may advance research on interrelationships between physical activity and cognitive and affective functions implicated in stress management.
Circadian Rhythm of Lipid Metabolism in Health and Disease
Authors: Zhang Zhihui , Xin Haoran , Li Min‐Dian 
Published: January 2020

AbstractThe circadian temporal organization of cellular functions segregates chemically incompatible processes into different times of the day. It is emerging that the molecular temporal organization of lipid metabolism throughout the day is crucial for physiological fitness, the dysfunction of which contributes to current epidemic metabolic diseases related to lipids. Here, current conceptual frameworks of the circadian clock system and knowledge of the circadian rhythm of lipid metabolism in different metabolic tissues and organs in health and disease are summarized. Recent advances in dietary and chemical approaches to modulate the circadian rhythm of lipids and the implications to treating human diseases are also reviewed.
Rational Microstructure Design on Metal–Organic Framework Composites for Better Electrochemical Performances: Design Principle, Synthetic Strategy, and Promotion Mechanism
Authors: Li Zhaoqiang , Ge Xiaoli , Li Caixia , Dong Shihua , Tang Rui , Wang Chengxiang , Zhang Zhiwei , Yin Longwei 
Published: January 2020

AbstractMetal–organic frameworks (MOFs) simultaneously containing metal ions and organic ligands have recently shown great potential for application in energy storage and conversion fields due to their controllable conversion into carbon materials or various metal species, which often exhibit superior electrochemical performance as electrode materials for energy storage and conversion. Nevertheless, the electrochemical energy storage performance of MOF derivatives can still be further enhanced through building composites with other functional materials. It is of great significance in developing new strategies of fabricating MOF composites to achieve electrode materials with improved charge transfer and electrochemical redox reaction kinetics. In this review, the novel design and strategies of MOF composites with various functional components are focused on, including carbon‐based materials (carbon nanotubes, graphene, etc.), metal oxides, 3D conductive substrates, polymeric materials, and the second MOFs and metal salts, especially their derivatives for energy storage and conversion fields. The key factors for controllable synthesis of various MOF composites and electrochemical performance enhancement mechanisms are discussed in detail. It is expected that this review will provide new inspiration for the development of MOF derivatives for energy storage and conversion.
A mobile data offloading framework based on a combination of blockchain and virtual voting
Authors: Hassija Vikas , Saxena Vikas , Chamola Vinay 
Published: January 2020

SummaryThe emergence of mobile cloud computing enables mobile users to offload computation tasks to other resource‐rich mobile devices to reduce energy consumption and enhance performance. A direct peer‐to‐peer connection among mobile devices to offload computation tasks can be a highly promising solution to provide a fast mechanism, especially for deadline‐sensitive offloading tasks. The generic blockchain‐based system might fail in such a scenario due to it being a heavyweight mechanism requiring high power consumption in the mining process. To address these issues, in this article, we propose a directed acyclic graph‐enabled mobile offloading (DAGMO) algorithm. DAGMO model is empowered by traditional blockchain features and provides additional advantages to overcome the fundamental limitations of generic blockchain. A game‐theoretic approach is used to model the interactions between mobile devices. The numerical analysis proves the proposed model to enhance the overall welfare of the participating nodes in terms of computation cost and time.
The changing water cycle: Freshwater in the Congo
Authors: Inogwabini Bila‐Isia 
Published: January 2020

AbstractClimate change in Africa is manifesting itself in the distribution and quantities of freshwater which are becoming serious security issues. Central Africa, particularly the Democratic Republic of Congo (DRC), with its abundant water, is caught in the middle of strategies to curb future effects of droughts, water scarcity and flooding across Africa. This article reviewed the current status of water and related biodiversity in DRC using a political economy, biological data and available social knowledge. Freshwaters hold the potentials to significantly contribute to the economy of DRC. However, fish stocks in some stretches of the Congo River are fished at intensities that exceed their productivity potential; water depths are decreasing in some others. Sources of the freshwaters of the Congo Basin cross borders of many countries but proper transboundary management plans to support cross‐border sustainable management of freshwaters are lacking. Stakeholders do not own freshwater sustainable management plans; growing populations and the drying up of large portions of Africa make that freshwater of the Congo, rather than being a uniting factor of the region, instead a security threat that Congo River Basin countries need to care about immediately. Caution should prevail in ways in which the freshwaters of the Congo Basin are exploited. Particularly, lack of in‐depth ecological knowledge about the biology and the mechanics of the Congo Basin's freshwaters call for careful scrutiny of the idea to export the freshwaters of Congo to refill the Lake Chad Basin as suggested by some politicians, since this could lead to an unprecedented ecological cataclysm.This article is categorized under:
Water and Life > Conservation, Management, and Awareness
Science of Water > Water Extremes
Engineering Water > Planning Water