bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-Effectiveness and Budget Impact of Emicizumab Prophylaxis in Haemophilia A Patients with Inhibitors
Authors: Cortesi Paolo Angelo , Castaman Giancarlo , Trifirò Gianluca , Creazzola Simona Serao , Improta Giovanni , Mazzaglia Giampiero , Molinari Angelo Claudio , Mantovani Lorenzo Giovanni 
Published: December 2019

AbstractRecent evidence demonstrated that weekly prophylaxis with subcutaneous bispecific antibody (emicizumab) has shown higher efficacy in adolescent and adults patients affected by haemophilia A (HA) with inhibitor, compared with patients treated on demand or on prophylaxis with bypassing agents (BPAs). However, no economic evaluations assessing the value and sustainability of emicizumab prophylaxis have been performed in Europe. This study assessed the cost-effectiveness of emicizumab prophylaxis compared with BPA prophylaxis and its possible budget impact from the Italian National Health Service (NHS) perspective. A Markov model and a budget impact model were developed to estimate the cost-effectiveness and budget impact of emicizumab prophylaxis in HA patients with inhibitors. The model was populated using treatment efficacy from clinical trials and key clinical, cost and epidemiological data retrieved through an extensive literature review. Compared with BPAs prophylaxis, emicizumab prophylaxis was found to be more effective (0.94 quality adjusted life-years) and cost saving (–€19.4/–€24.4 million per patient lifetime) in a cohort of 4-year-old patients with HA and inhibitors who failed immune tolerance induction. In the probabilistic sensitivity analysis, emicizumab prophylaxis had always 100% probability of being cost-effective at any threshold. Further, the use of emicizumab prophylaxis was associated to an overall budget reduction of €45.4 million in the next 3 years. In conclusion, the clinically effective emicizumab prophylaxis can be considered a cost-saving treatment for HA with inhibitor patients. Furthermore, emicizumab treatment is also associated to a significant reduction of the health care budget, making this new treatment a sustainable and convenient health care option for Italian NHS.
Vestibular Migraine: Treatment and Prognosis
Authors: von Brevern Michael , Lempert Thomas 
Published: December 2019

AbstractTreatment of vestibular migraine currently lacks a firm scientific basis, as high quality randomized controlled trials are not available. Therefore, recommendations are largely borrowed from the migraine sphere. The first therapeutic step is explanation and reassurance. Many patients do not need pharmacological treatment, as attacks may be infrequent and tolerable. Acute attacks can be ameliorated in some patients with antiemetic drugs such as diphenhydramine, meclizine, and metoclopramide. Frequent attacks may warrant pharmacological prophylaxis with metoprolol, amitriptyline, topiramate, valproic acid, or flunarizine. Nonpharmacological measures including regular exercise, relaxation techniques, stress management, and biofeedback may be similarly effective and can be combined with a pharmacological approach. Limited data indicate that the prognosis appears to be less favorable for vestibular migraine than for migraine headaches.
Functional Outcome for Arthroscopic Treatment of Septic Arthritis of the Wrist
Authors: Chow Esther M. W. , Lau Jimmy K. Y. , Liyeung Lucci L. C. , Chau W. W. , Mak Michael C. K. , Tse W. L. , Ho P. C. 
Published: December 2019

Abstract
Background Septic arthritis is a potentially joint-destructing condition if not treated properly. Septic wrist accounts for ∼5% of all septic arthritis. Arthroscopic lavage is a well-documented treatment for septic arthritis of the knee, hip, or shoulder only. Previous studies on septic wrist were limited to case reports or retrospective studies focusing on open treatment, and functional outcome was seldom documented. Our study aims to evaluate the effectiveness of arthroscopic treatment and to investigate the functional outcome.
Materials and Methods Patients were retrospectively reviewed over a period of 10 years. Parameters including age, gender, history of prior injury, duration of symptoms, joint aspirates and intraoperative tissue culture, radiological and arthroscopic findings, antibiotics used, number of operations, and hospital stay were reviewed. Functional outcomes were evaluated with QuickDASH (disabilities of the arm, shoulder, and hand) score.
Results From 2007 to 2016, 14 patients (15 septic wrists) underwent arthroscopic surgery. One patient had bilateral involvement. The average age was 63.9 years and the average duration of symptoms was 6.08 days. Average follow-up time was 10 months. All except two patients (85.7%) responded to single arthroscopic treatment. Two required subsequent operations for concomitant tenosynovitis. There were no major complications. The most common isolated organism was Staphylococcus aureus. Only one case had severe joint erosion during follow-up. The average QuickDASH score was 19.7. Duration of symptoms 5 days or more before admission was associated with higher QuickDASH score (p = 0.04).
Conclusion Early arthroscopic treatment should be considered for all patients admitted for septic arthritis of the wrist if not contraindicated.
Level of Evidence This is a Level III, retrospective review.
Managing Preoperative Hemostasis in Patients with Inherited and Acquired Bleeding Disorders
Authors: Mensah Patrick Kyei , Pavord Sue 
Published: December 2019

AbstractInherited and acquired bleeding disorders pose significant hemostatic challenges for surgery. Patients at particular risk of bleeding include those with inherited bleeding disorders such as hemophilia, von Willebrand disease, and platelet function defects; those on antiplatelet agents or anticoagulants; and those with acquired conditions such as immune thrombocytopenic purpura, liver disease, or renal impairment. Each has its own specific challenges and close collaboration between the anesthetic, surgical, and hematology teams is crucial. Optimizing surgical hemostasis for patients at risk involves attention to detail, with careful preoperative planning, meticulous surgical technique, prompt identification of complications and judicious use of hemostatic agents and blood components. This article gives an overview of the bleeding risks involved and therapeutic options to overcome them.
The Role of Platelets in Cancer-Related Bleeding Risk: A Systematic Review
Authors: Larsen Julie Brogaard , Hojbjerg Johanne Andersen , Hvas Anne-Mette 
Published: December 2019

AbstractCancer patients face an elevated risk of bleeding, and here platelets play a pivotal role. The association between platelet count and bleeding, as well as safe thresholds for prophylactic platelet transfusion, is described mainly in hematological malignancies, and knowledge is sparse for patients with solid tumors. Platelet function tests may further improve bleeding risk assessment in cancer patients. This study provides a systematic review of the available literature on associations between platelet count and/or function and bleeding in adult cancer patients. The review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. PubMed, Embase, and Web of Science were searched up to August 2019. The National Heart, Lung, and Blood Institute's tools were used for quality assessment. In total, 52 studies investigated associations between bleeding and platelet count (n = 40) or function (n = 12) in patients with hematological malignancy (n = 31), solid tumors (n = 11), or both (n = 10). The majority of included studies rated good (n = 23) or fair (n = 25). The association between platelet count and bleeding was most pronounced at platelet counts ≤ 10 × 109/L but was less evident for solid tumors. Overall, reduced platelet function was significantly associated with bleeding risk. Thus, the available evidence supports current guidelines for prophylactic platelet transfusions at platelet count ≤ 10 × 109/L in hematological cancer patients, whereas more evidence is needed in patients with solid tumors. Platelet function analysis may be valuable in assisting bleeding risk assessment in cancer patients but is sparsely investigated so far.
A Review on the Update of Combined Hepatocellular Cholangiocarcinoma
Authors: Komuta Mina , Yeh Matthew M. 
Published: December 2019

AbstractCombined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a primary liver tumor with neoplastic components of both hepatocytic and cholangiocytic differentiation. This unique neoplasm is gaining increasing recognition due to the intriguing pathology, tumor biology, and clinical behavior. It also poses challenges in diagnosis, treatment, and research, largely because of its histological and phenotypic diversity that lead to confusion in terminology and classification. There have been efforts attempting to unify the terminology of this neoplasm recently. Advances in investigation in various aspects have also been made. This review aims to update the terminology, classification, and clinical and pathological characteristics of cHCC-CCA.
Anisotropic turbulence of kinetic Alfvén waves and heating in solar corona
Authors: Dinesh Singh Hemam , Singh Jatav Bheem 
Published: December 2019

AbstractUnderstanding solar coronal heating has been one of the unresolved problems in solar physics in spite of the many theories that have been developed to explain it. Past observational studies suggested that kinetic Alfvén waves (KAWs) may be responsible for solar coronal heating by accelerating the charged particles in solar plasma. In this paper, we investigated the transient dynamics of KAWs with modified background density due to ponderomotive force and Joule heating. A numerical simulation based on pseudo-spectral method was applied to study the evolution of KAW magnetic coherent structures and generation of magnetic turbulence. Using different initial conditions in simulations, the dependence of KAW dynamics on the nature of inhomogeneous solar plasma was thoroughly investigated. The saturated magnetic power spectra follow Kolmogorov scaling ofk−5/3in the inertial range, then followed by steep anisotropic scaling in the dissipation range. The KAW has anisotropy ofk∥∝k⊥0.53,k∥∝k⊥0.50,k∥∝k⊥0.83andk∥∝k⊥0.30depending on the kind of initial conditions of inhomogeneity. The power spectra of magnetic field fluctuations showing the spectral anisotropy in wavenumber space indicate that the nonlinear interactions may be redistributing the energy anisotropically among higher modes of the wavenumber. Therefore, anisotropic turbulence can be considered as one of the candidates responsible for the particle energization and heating of the solar plasmas.
Soil chemical properties and corn productivity as affected by application of different types of fertilizer and planting method in acid sulfate soil
Authors: Hanifa H , Utami S N H , Wulandari C , Yusuf W A 
Published: December 2019

Abstract
Acid sulfate soil is use as an alternative in optimizing suboptimal land to achieve corn self-sufficiency. Balanced fertilization plays an important role in efforts to improve corn yields. This study aimed to determine the effect of planting methods and optimal dose of fertilization. This research was carried out in potential acid sulfate soils with B type overflow. This study was arranged in factorial Randomized Complete Block Design (RCBD) consist of 2 factors. The first factor was the planting method consist of Zigzag, Legowo and Conventional planting methods. The second factor was the fertilizer types comprising NPK phonska 450 kg ha−1 + urea 300 kg ha−1 + SP36 300 kg ha−1, NPK mutiara 450 kg ha−1 + urea 300 kg ha−1 + SP36 300 kg ha−1, Urea 450 kg ha−1 + SP36 300 kg ha−1 + KCl 300 kg ha−1, and NPK phonska 300 kg ha−1 + SP36 300 kg ha−1. The results showed that the application of different types of fertilizer and planting methods could improve pH in all treatments from very acidic to acidic. pH, EC, and Eh of acid sulfate soils at 70 and 100 days after planting (dap) were not affected by the interaction between different types of fertilizer and planting methods. Total N content in Zigzag planting method was significantly lower compared to in Conventional planting methods. Meanwhile, available P increased to very high. The Exchangeable K content was only increased in the fertilizer treatment with the addition of KCl reaching a value of 0.42 cmol + kg−1 at 30 dap. Zigzag planting method significantly increased corn yield to 31% higher than in Legowo planting method and 16% higher than in the Conventional planting method. The application of fertilizer with a mixture of KCl significantly increased corn yield to 26.25%. Therefore, the Zigzag planting method and fertilizer with KCl mixture are recommended for corn cultivation in acid sulfate soils.
Effects of NPK and mycorrhizae on the growth, P uptake of soybean, and soil chemist in peatland, Pelalawan, Riau
Authors: Sasongko S R , Utami S N H , Purwanto B H 
Published: December 2019

Abstract
Peatlands have great potential if they are used as agricultural lands. However, more attention is necessary for the management of water, soil pH, and the provision of nutrients. This research was conducted to determine the growth and P uptake of soybean plants on peatland as affected by fertilizer treatment and mycorrhizae application in soybean plants. The study was conducted in the peatland of Pelalawan Village, Pelalawan District, Pelalawan Regency, Riau using soybean plants cultivar Anjasmoro. The research was arranged in a complete randomized complete block design consisting of two factors. The first factor was fertilizer treated, comprising N1 (no fertilizer), N2 (150 kg ha−1 compound NPK fertilizer), and N3 (300 kg ha−1 compound NPK fertilizer). Meanwhile, the second factor was application of mycorrhizae comprising M1 (without mycorrhizae) and M2 (with mycorrhizae). Each treatment combination consisted of three replications. The data were analyzed with analysis of variance at a 5% confidence level and tested using DMRT test. The results showed that combination of mycorrhizae and NPK 300 kg ha−1 gave the best effect from other treatement on the growth, P uptake of soybean and the soil chemist.
Improved black soybean performances grown on selected highly weathered soils by using bio-nano-ortho silicic acid
Authors: Goenadi D H , Santi L P , Dariah A , Barus Y , Kalbuadi D N 
Published: December 2019

Abstract
The objectives of the study were to determine the potential use of bio-nano-ortho silicic acid (OSA) originated from locally mineral enriched with silica-solubilizing microbes to improve yield, reduce chemical fertilizer dosage, and increase water use efficiency (WUE) of black soybean grown on selected highly weathered soils. The first-year (2017) study was conducted at Majalengka and Natar area and arranged in a random block design (RBD) with three replicates, using a Detam-1 variety. Treatments of NPK fertilizers were 0, 50, 75, and 100% of standard recommended dosages in combination with 0, 2, 4, and 6 L bio-nano OSA Ha−1. In general, application of 4 L bio-nano OSA Ha−1 saved 32% NPK fertilizer dosage and improved growth and yield of Detam-1. The second year (2018) trials consisted of no fertilization (P0), farmer standard NPK fertilization (P1), P1 + organic matter (P2), 4 L bio-nano OSA Ha−1 + NPK (P1), 50% (P3); and 75% (P4) respectively, arranged in a RBD with three replicates at three regions, i.e. Majalengka (Alfisols), Natar (Ultisols), and Indramayu (Alfisols). The results confirmed that the application of bio-nano OSA at 4 L Ha−1 improved nutrient use and WUE as well as yield of Detam-1 on all three soils studied.
Total microbes and soil respiration on land without applications and with the application of oil palm empty fruit bunches in different depths
Authors: Sakiah  
Published: December 2019

Abstract
Oil palm empty fruit bunches as a by-product of palm oil fresh fruit bunches processing are generally applied in oil palm plantation areas. This research aim was to determine the effect of oil palm empty fruit bunches application on total microbes and soil respiration. This research used a factorial randomized block design. Factor I is the sampling area, consisting of areas without application and area with the application of oil palm empty fruit bunches (OPEFB). Factor II is the depth of soil sampling, consisting of a depth of 0-10 cm, depth of 10-20 cm, depth of 20-30 cm and depth of 30-40 cm. The total microbes in the area with OPEFB application were 33.373 × 106 CFU ml−1 with soil respiration of 2.257 mg CO2 day−1. On land without OPEFB application, total microbes were 16.64 × 106 CFU ml−1 with soil respiration of 12.20 mg CO2 day−1. On differences in the depth of soil sampling, the highest total microbes were found at a depth of 10-20 cm i.e. 33.998 × 106 with soil respiration of 19.14 mg CO2 day−1. The application of oil palm empty fruit bunches had a positive contribution to increase total microbes and respiration in the soil.
The impact of ridge direction and latex on the yield of potato (Solanum tuberosum l.) in typic hapludands, Pengalengan, West Java
Authors: Siswanto S Y , Achmad T P , Sule M I S 
Published: December 2019

Abstract
The objective of this experiment was to find out the effect of ridge direction and latex soil conditioner on potatoes yields on Typic Hapludands from Pangalengan. The experiment was conducted in Pangalengan, with elevation 1,600 meters above sea level and 30% of slope steepness. The experiment used a split plot design with 12 treatments and three replications. The main plot ridge direction consists of: in line with slope direction, in line with contour, and diagonal. The sub plot was latex concentration level as follow: 0%, 0.6%, 1.2% and 1.8%. The result of the experiment showed that there was no interaction effect between ridge direction and latex soil conditioner. The independent effect of latex just influenced potatoes yields. Potatoes yield of latex 0%, 0.6%,1.2% and 1.8% was 72.97 kg was 74.47 kg, 75.14 kg and 76.48 kg, respectively.
A chronosequence study of soil properties and microclimate in the reclamation area of Batu Hijau Mine, West Sumbawa
Authors: Iskandar  , Suryaningtyas D T , Baskoro D P T , Budi S W , Gozali I , Maswahenu M 
Published: December 2019

Abstract
The objective of this study was to characterize soil physical and chemical properties, development of soil and microclimate condition according to the time sequence of revegetation. Sampling and observation were conducted in revegetation areas aged 2 to 8 years old and in the natural forest for comparison. Disturbed soil samples were taken from three depths while undisturbed soil samples were taken from two depths. Light intensity, air temperature, humidity and soil temperature were measured for microclimate analysis. The results showed that the soil had clay loam and loam texture with relatively high density and low permeability. Natural forest soil had lower density and higher permeability. Low soil fertility was indicated by low organic-C, total-N, available P and exchangeable K. Exchangeable-Ca and -Mg and cation exchange capacity of the soil in revegetation area were higher than in the natural forest soil. Only the content of organic-C and total-N in the first 5 cm layer of the soil increased along with the increasing revegetation age, while other parameters of soil properties showed no differences. Falcataria moluccana, Anthocephalus cadamba and Melochia umbelata were the dominant vegetation found in sapling, pole and tree. Light intensity, air temperature and soil temperature tended to decrease, while humidity increased with the increasing age of revegetation.
Composite Image with a Geographic Information System Approach
Authors: Kelik Nugroho Arief , Permadi Ipung 
Published: December 2019

Abstract
Geographic information systems are used for spatial data processing. Data processing results from the system can be used as a tool to determine the condition of an area. By using several components one of which is coloring in geographical conditions in the region. The process of combining several colors to form a composite image that can show the clarity of the object. The results obtained from this study reveal the clarity of objects in the Banyumas Regency region by using levels in the band composition in spatial imagery
Hydrothermal synthesis of single-crystal Cr-doped SrTiO3 for efficient visible-light responsive photocatalytic hydrogen evolution
Authors: Jiang Daixun , Sun Xun , Wu Xilu , Shi Liang , Du Fanglin 
Published: December 2019

Abstract
Visible-light-driven Cr-doped SrTiO3 nanocubes were successfully synthesized by hydrothermal method in alkaline KOH conditions. X-ray diffraction spectroscopy (XRD), Raman spectra, x-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were used to characterize the samples, and the Cr-doped SrTiO3 possess cubic morphology with about 30–50 nm in size, and single-crystal feature. In addition, the Cr-doped SrTiO3 extended light-harvesting properties to visible-light region which was testified by UV–vis absorption spectra, and excellent charge transfer and separation efficiency were approved by photo fluorescence spectra (PL), electrochemical impedance spectroscopy (EIS) and photocurrent response measurements. Among the synthesized photocatalysts, SrTiO3 nanocubes doped with 2% Cr by molar ratio exhibits the highest photocatalytic activity, achieving 11.66 μmol of H2 evolution during 5 h visible-light irradiation. This study provides a facile and effective way to enhance the performance of SrTiO3-based photocatalysts.
Impact of ECAP on wear performance of Al–Mn magnesium alloy
Authors: K R Gopi , H Shivananda Nayaka 
Published: December 2019

Abstract
The current study examines the wear performance of deformed AM90 magnesium alloy using pin-on-disc wear test apparatus under varying load of 30 and 40 N with the sliding distance of 2500 m and 5000 m at constant sliding speed of 3 m s−1. The samples were processed through equal channel angular pressing were subjected to microstructural, wear studies and are characterized by optical and scanning electron microscopy. Vickers microhardness was carried out to evaluate the relation between the wear behavior of homogenized and ECAP processed samples. Increment in number of ECAP passes increased the grain refinement as observed in the microstructure with reduction in grain size from ∼70 μm (homogenized sample) to ∼4 μm (ECAP 4 pass sample). Increase in wear resistance and hardness were observed for processed samples and the worn faces are analyzed by scanning electron microscopy and energy-dispersive x-ray spectrometer. The worn surfaces revealed the occurrence of wear debris, delamination, ploughing in the direction of sliding and the predominant wear mechanism was considered to be the combination of oxidation and abrasive wear.
Effect of laser fluence on structural and optical properties of CuxS films grown by pulsed laser deposition at different wavelengths
Authors: Rodríguez-Hernández P E , Quiñones-Galván J G , Meléndez-Lira M , Santos-Cruz J , Contreras-Puente G , de Moure-Flores F 
Published: December 2019

Abstract
CuxS thin films were grown onto soda-lime glass substrates by pulsed laser deposition at two different wavelengths: 1064 and 532 nm. X-ray diffraction, Raman and UV–vis spectroscopies were used to characterize the CuxS films. Results are presented as a function of laser fluence. XRD patterns indicate that covellite and chalcocite phases were obtained. Raman spectra showed that chalcocite is the predominant phase in the crystalline samples. Optical band gap values are between 2.29 and 2.74 eV for ablation with 1064 nm wavelength; meanwhile, for 532 nm band gap values varied from 2.24 to 2.66 eV; which are in the range of expected values for CuxS films. At 1064 nm and 4.4 J cm−2 sample presented the highest optical absorbance in the visible range, which corresponds to the highest thickness. These are the best growth parameters for CuxS films in order to be used as absorber films for solar cells applications.