bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transitioning to oral therapy compared to IV in Staphylococcus aureus bloodstream infections: a systematic review and meta-analysis
Authors: Salma Omme , Samee Mohammed Abdul , Mustafa Muhammad Saqlain , Haseeb Abdul , Ho Wing Lam , Chan Hin Ming , Pons Andrea Gómez , Shafique Muhammad Ashir , Ali Syed Muhammad Sinaan , Raheem Abdul , Fadlalla Ahmad Tagwa Kalool 
Published: December 2024

Background and Objective:

Staphylococcus aureus bloodstream infections pose a significant threat to public health and necessitate substantial healthcare resources. The optimal antimicrobial therapy for these infections remains a subject of debate. This systematic review and meta-analysis evaluated the efficacy and safety of early transition to oral antimicrobial therapy compared with continued intravenous (IV) therapy in patients with MRSA and MSSA bloodstream infections.

Method:
A PRISMA-guided systematic review and meta-analysis compared the early transition from intravenous to oral antibiotics with continued intravenous therapy in patients with S. aureus infections, utilizing relevant studies from the PubMed, Embase, Scopus, and Web of Science databases from August 2003 to June 2024.

Results:
This meta-analysis of 11 studies (N = 54–220, primarily male, age: mid-30s to early 70s) revealed a 71.6% higher risk of all-cause mortality for patients transitioned to early oral therapy than for those who continued IV therapy (RR: 1.716; 95% CI: 1.039–2.836; P = 0.035; I2 = 44%). Treatment failure, rehospitalization rates, adverse events, and hospital stay lengths did not differ significantly between groups.

Conclusion:
Early oral antimicrobial therapy for S. aureus bloodstream infections significantly reduces mortality compared to prolonged intravenous treatment, without increasing the incidence of adverse events or the risk of rehospitalization, suggesting its safety and efficacy as an alternative therapeutic approach; however, further randomized controlled trials are necessary to corroborate these findings.
The niosomal nelarabine as a promising nano combination for retinoblastoma treatment: an in vitro study—experimental research
Authors: Tohidian Mobina , Esmaeil Nafiseh , Soleimani Mitra , Khanehzad Maryam , Naderi Majd Amir H. , Zarinfard Giti 
Published: December 2024

Introduction:
Retinoblastoma (RB), the most commonly occurring intraocular malignancy among children globally, represents 3% of childhood cancers. In the current study, the authors aim to evaluate the effectiveness of a new formulation of nelarabine (niosomal nelarabine) on RB cancer cells.

Methods:
Field emission scanning electron microscopy (FE-SEM) and dynamic light scattering (DLS) characterized the physical properties of nelarabine nanoparticles. After cultivation of the Y79 cell line, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test was performed to determine IC50 of niosomal nelarabine (Nio-Nelarobine) and also the cytotoxicity of Nio-Nelarobine and doxorubicin against Y79 cell line was investigated. The level of apoptosis was assessed by flow cytometry in selected groups. Also, the PTEN/AKT/FOXO1 gene expression level was measured using qRT-PCR.

Results:
Y79 cell lines were treated with Nio-Nelarobine and doxorubicin. The treatment resulted in a dose-dependent inhibition of Y79 cell viability. However, Nio-Nelarobine showed a higher inhibitory activity with a diameter of about 167 nm. Both Nio-Nelarobine and doxorubicin induced apoptosis in cells, but Nio-Nelarobine treatment resulted in a higher number of apoptotic cells than doxorubicin treatment. The qRT-PCR results showed that the treatment with Nio-Nelarobine and doxorubicin led to an increase in the expression of PTEN and FOXO1 genes, while decreasing the expression of the AKT gene. Furthermore, the statistical significance of these results was higher in the Nio-Nelarobine group than in the doxorubicin group.

Conclusions:
Nio-Nelarobine may be a functional therapeutic combination for RB treatment. Further experimental and preclinical investigations are necessary to verify this impact in greater detail.
Multicenter Randomised Controlled Trial of Single versus Double Venous Outflow Reconstruction in Right lobe Living Donor Liver Transplantation- Venous Outflow in Liver Transplantation (VOLT) Trial
Authors: Reddy Mettu Srinivas , Koneti Akshadhar J. , Chaudhary Abhideep , Rammohan Ashwin , Yelakanti Raghavendra Babu , Mallick Shweta , Patcha Rajanikanth , Singh Vipin Pal , Krishnan Satish Kumar , Kumar Niteen , Gopal Prasanna V. , Rela Mohamed , Sudhindran Surendran 
Published: December 2024

Objective:
To compare early patency and outcomes of single outflow (SOT) and double outflow (DOT) reconstruction in right lobe living donor liver transplantation (RtLDLT) in a multicenter open-labelled randomized controlled trial.

Summary Background Data:
Optimum graft venous outflow is a key factor in determining outcomes of RtLDLT. There is no data directly comparing SOT and DOT technique of graft outflow reconstruction.

Methods:
Adult patients undergoing RtLDLT needing anterior sector vein (ASV) reconstruction were enrolled. Prosthetic graft was used to create a neo-middle hepatic vein (neoMHV). Web-based permuted block randomization was used to allocate patients to SOT or DOT (1:1) prior to graft implantation. Primary endpoint was neoMHV patency upto 6 weeks. Secondary endpoints were post-operative morbidity and survival. Intention-to-treat and as-treated analyses are reported.

Results:
Five centers randomized 219 patients to SOT (n=110) or DOT (n=109). Both groups were similar in baseline characteristics. SOT had better neoMHV patency at 2 weeks (92.5% vs. 82.9%, P=0.032), 4 weeks (84% vs. 69%, P=0.011) but not at 6 weeks (69.5% vs. 59.2%,P=0.124). Cox- proportional hazards analysis revealed DOT (HR- 1.56 (95%ci=1.02,2.4); P=0.041) and use of Dacron graft (HR-2.83(95% ci=1.16,6.94), P=0.023) as independent risk factors for neoMHV thrombosis. SOT was associated with better in-hospital survival (97.3% vs. 90.8%; P=0.044) but similar one-year survival (89% vs. 85%, P=0.340). SOT was associated with improved survival in patients who developed early allograft dysfunction or needed re-operation.

Conclusions:
SOT has better early neoMHV patency than DOT and may be associated with better early survival.
Evaluating buyer performance through supplier satisfaction: a balanced scorecard and fuzzy logic approach
Authors: Meena Purushottam L , Tibrewala Rajen 
Published: December 2024

PurposeThis study develops and validates a comprehensive framework integrating the balanced scorecard (BSC) and fuzzy logic to evaluate supplier satisfaction in the Indian power sector.Design/methodology/approachA mixed-methods approach, including the literature review, expert consultations and a survey of 300 suppliers, was employed. The BSC categorized supplier satisfaction across financial, purchasing, coordination and corporate perspectives. Fuzzy set theory and fuzzy logic converted qualitative data into quantitative measures.FindingsKey areas for improvement across financial, purchasing, coordination and corporate perspectives were identified. The developed Supplier Satisfaction Index offers a nuanced tool for benchmarking and enhancing supplier relationships.Research limitations/implicationsWhile the study provides a comprehensive framework for evaluating supplier satisfaction, it is limited to the context of the Indian power sector. Future research could extend the application of this framework to different industries and geographical contexts to assess its generalizability.Practical implicationsThe findings offer actionable insights for practitioners to improve supplier satisfaction through targeted strategies in financial interactions, purchasing clarity, coordination efficiency and corporate practices. Implementing these strategies can enhance supplier relationships and overall supply chain performance.Originality/valueThis research extends the BSC’s applicability to external supplier relationships. It demonstrates robustness when integrated with fuzzy logic and offers a multidimensional approach to supplier satisfaction evaluation, addressing the inherent ambiguities and subjectivities in traditional assessments.
Exploring the evolution of ergonomic practices on construction sites in Nigeria
Authors: Ilesanmi Oluwadamilare Olamide , Moyanga Dorcas T. 
Published: December 2024

PurposeErgonomic practices significantly enhance productivity, reduce injuries and improve worker satisfaction in construction sites. However, a key issue in the Nigerian construction industry is the limited awareness and implementation of these practices. This study addresses this issue by raising awareness and driving ergonomic improvements to advance occupational health and safety standards.Design/methodology/approachA quantitative research method was employed, using close-ended questionnaires distributed to construction professionals, including architects, builders, engineers and quantity surveyors. The data collected were analyzed through statistical tools such as percentages, frequencies and mean scores. The Kruskal–Wallis H-test was used to determine significant differences in respondents’ opinions.FindingsThe study found that construction professionals have limited knowledge of ergonomic practices, and the implementation of these practices within the industry is minimal, raising concerns about occupational health and safety.Practical implicationsThis article provides a comprehensive roadmap for developing economies like Nigeria to improve the understanding of ergonomic practices among construction professionals. It also outlines how collaborative efforts among key stakeholders, including higher education institutions, government, policymakers, lawmakers, financial institutions and professional bodies, can enhance the awareness and implementation of these innovative practices.Originality/valueWhile extensive research has been conducted on ergonomic practices in developed countries, few studies have examined their awareness and implementation in developing nations, particularly Nigeria. This study addresses this gap from the perspective of construction professionals.
Artificial intelligence in agile human resource practices: systematic literature review and bibliometric analysis
Authors: Panda Gayatri , Aggarwal Shilpee , Kaswan Mahender Singh , Dhillon Kavisha 
Published: December 2024

Purpose
This study aims to review and synthesize existing research in the field. Additionally, this study identifies emerging themes and future research opportunities based on the discussions within these studies. This research also develops a model to integrate artificial intelligence with agile human resource (AHR) practices and strives to outline potential directions for future researchers.

Design/methodology/approach
This study adopted a systematic literature review (SLR) and bibliometric analysis followed by content analysis through bibliographic coupling to analyze the identified literature. The SCOPUS database was used in this study, using a search string of keywords to identify the relevant research literature. The initial extraction resulted in 151 articles after adopting a series of inclusion–exclusion criteria, which led to the final attainment of 73 articles to be included for further analysis and discussion.

Findings
This study through the extant literature identified five themes and foundations of artificial intelligence in AHR practices research and developed a model for future investigation by future researchers.

Originality/value
To the best of the authors’ knowledge, this study is one of a kind that explores artificial intelligence within AHR practices for improved employee and organizational well-being. Thus, developing a synthesized work provides a comprehensive picture of the research domain.
Network governance in healthcare systems: a systematic review of the network-level factors
Authors: Aalikhani Reza , Rasouli Mohammad Reza , Ghanbari Hossein , Fathian Mohammad , Ali ahmadi Alireza 
Published: December 2024

PurposeInterorganizational collaborations are crucial for delivering high-quality, integrated healthcare services. To maximize the benefits of these collaborative networks, effective governance structures and mechanisms must be in place. While previous studies have extensively examined organizational-level factors, such as partner capabilities and backgrounds, this study focuses on network-level factors, including collaboration structures and tie characteristics that shape effective network governance.Design/methodology/approachA systematic literature review (SLR) was conducted to identify and synthesize the key network-level factors influencing governance structures and mechanisms in healthcare networks.FindingsThe review identified 22 critical factors, categorized into three primary groups that impact network governance. These findings offer a robust foundation for developing context-sensitive governance models tailored to healthcare systems.Practical implicationsThis study provides valuable insights for healthcare practitioners, policymakers and researchers by highlighting key factors that can improve interorganizational collaboration within healthcare systems. The findings contribute to both theory and practice, with the potential to enhance healthcare service delivery and patient outcomes.Originality/valueThis study is the first to systematically identify and categorize the network-level factors that influence governance structures and mechanisms in healthcare networks, providing a comprehensive and novel contribution to the field.
Temporal changes in smoking prevalence among adolescents across 23 countries
Authors: Hong Seohyun , Son Yejun , Lee Myeongcheol , Park Jaeyu , Lee Hayeon , Lee Hyeri , Lee Hojae , Kim Hyejun , Dragioti Elena , Fond Guillaume , Boyer Laurent , López Sánchez Guillermo F. , Tully Mark A. , Rahmati Masoud , Woo Selin , Yon Dong Keon , Smith Lee 
Published: December 2024

AbstractAimThis study aimed to investigate temporal changes in smoking prevalence among adolescents aged 13–15 across 23 countries and to assess individual and country‐level factors influencing smoking behaviour.MethodsThis study used data from 168 286 young adolescents aged 13–15 years obtained from the Global School‐based Student Health, 2003–2021. Linear regression models and meta‐analyses were conducted to analyse the changes in current smoking prevalence among young adolescents.ResultsAmong the 23 countries, smoking prevalence decreased in six countries, including Argentina, Fiji, Jamaica, Samoa, Tonga and Uruguay, while it increased in four countries, namely Guyana, Morocco, Thailand and Vanuatu. The prevalence of smoking was higher among male adolescents at 15.5% (95% CI 13.8%–17.2%) compared to females at 8.0% (95% CI 6.7%–9.3%). Adolescents exposed to secondhand smoke had a prevalence of 16.3% (95% CI 14.5%–18.2%), significantly higher than 4.2% (95% CI 3.7–4.6) in those not exposed. Smoking prevalence was 16.5% (95% CI 14.8%–18.2%) among those with smoking parents or guardians, compared to 8.1% (95% CI 7.1%–9.1%) among those without.ConclusionThe findings highlight the need for tailored tobacco control measures to reduce adolescent smoking globally. Strengthening policy enforcement and addressing social determinants of smoking are critical to achieving further reductions.
Reasons for seeking internet‐delivered treatment for individuals with obsessive‐compulsive disorder
Authors: Melkonian Maral , McDonald Sarah , Karin Eyal , Titov Nickolai , Dear Blake F. , Wootton Bethany M. 
Published: December 2024

AbstractObjectivesPatients with obsessive‐compulsive disorder (OCD) face multiple barriers when accessing treatment and rarely receive best‐practice cognitive behaviour therapy (CBT) when they seek help. Remote treatments, such as internet‐delivered CBT (ICBT), enhance access to evidence‐based treatments. To date, no known studies have examined the reasons individuals seek remote treatment over traditional in‐person treatment for OCD. Thus, the aim of the current study was to examine the treatment histories of individuals who completed ICBT for OCD and their reasons for seeking ICBT.MethodsOne hundred and sixty‐six participants (Mage = 33.88; SD = 13.41, 71.7% female) were included in the study.ResultsAlmost three‐quarters of the sample had previously spoken to a health professional about their OCD symptoms. General practitioners were the most frequently consulted health professionals initially (41.7%), while psychologists were the most frequently consulted overall (81.7%). Supportive counselling (74.2%) and medication (72.5%) were the most common forms of treatment ever received. Of those who had received CBT for OCD, only 20.0% (12.5% of the overall sample) likely received best‐practice CBT. The most frequently endorsed reasons for seeking ICBT over in‐person treatment related to having no access to face‐to‐face treatment in the community (25.9%) and having found previous face‐to‐face treatment unhelpful (24.1%). Group differences in reasons for seeking ICBT over face‐to‐face treatment emerged based on geographical location, OCD severity and presence of comorbid depressive symptoms.ConclusionsEvidence‐based treatment for OCD is underutilized in the community highlighting the need to develop and disseminate evidence‐based remote treatments for OCD.
Youth experiences in gender–sexuality alliances predict academic engagement but not disaffection through social–emotional wellbeing
Authors: Poteat V. Paul , Calzo Jerel P. , Yoshikawa Hirokazu , Kellogg Daniel , Marx Robert A. , Richburg Abigail , Lipkin Arthur 
Published: December 2024

AbstractExperiences in gender–sexuality alliances (GSAs) could predict youth's academic engagement through improved social–emotional wellbeing (indicated by school belonging, hope, and positive and negative affect). This study utilized three waves of data, each spaced 2–3 months apart, among 627 youth (87% LGBQ+, 45% trans/nonbinary, 48% youth of color) ages 11–22 (Mage = 15.13) in 51 GSAs in the United States in 2021–2022. Greater peer responsiveness in the GSA predicted increased academic engagement through increased wellbeing overall and specifically through hope and decreased negative affect. Advisor responsiveness and GSA leadership correlated with wellbeing and academic engagement in bivariate analyses but were not predictive in the comprehensive model. GSA experiences were uncorrelated with academic disaffection. Findings suggest how GSAs promote youth's wellbeing and academic engagement.
Dual‐use research assessment in emerging medical biotechnology: An ethical perspective from China
Authors: Wang Xiaonan , Zhai Xiaomei 
Published: December 2024

AbstractEmerging medical biotechnology, with its dual‐use nature, presents both unprecedented opportunities and challenges for human society. As we benefit from technological innovation, it is crucial for Chinese academics and policymakers to effectively identify and address potential risks. However, the current framework for evaluating dual‐use research faces multiple challenges, including difficulties in identifying dual‐use issues, a lack of consideration for broader impacts in assessments, and a lack of consensus on balancing benefits and risks. Furthermore, inadequacies in the review mechanism, such as uneven progress among institutions, insufficient review capabilities, and lacking specialized knowledge among assessment personnel, hamper the effectiveness of evaluation efforts. This article aims to explore these challenges and propose practical recommendations for strengthening the evaluation and governance mechanisms of dual‐use research. By effectively mitigating the risks associated with dual‐use research, it facilitates the promotion of responsible scientific progress in emerging medical biotechnologies in China and internationally.
Opportunity to Leverage Tactics Used by Skilled Fishers to Address Persistent Bycatch Challenges
Authors: Roberson Leslie A. , Brown Christopher J. , Klein Carissa J. , Game Edward T. , Wilcox Chris 
Published: December 2024

ABSTRACTEffective management of shark bycatch is urgently needed to reverse widespread population declines, especially in longline fisheries that are estimated to be responsible for half of global shark catch. Management of shark catch typically focuses on the safe release of landed sharks, with limited attention to reducing the initial catch. Where controls on fishing effort or catch do exist, management frameworks tend to treat fishing fleets as homogeneous units. The underlying assumption is that fishers have similar abilities to catch target species and avoid bycatch. We test this assumption by analysing variability in shark bycatch rates among individual vessels in an industrial tuna longline fleet operating in the Western Pacific. Controlling for factors such as geographic location, time of day and gear depth, we find that individual vessels drive highly variable bycatch rates of blue (Prionace glauca) and silky sharks (Carcharhinus falciformis) – two shark species with the highest global catch volumes. Additionally, we found that the operating company can influence fisher performance. As countries and regional organisations increasingly adopt shark conservation plans and make international conservation commitments, it is crucial to identify viable new strategies that do not unduly burden the industry or penalise good actors. Tailoring management actions to individual fishers and companies – holding high‐bycatch fishers accountable and incentivising low‐bycatch fishers to continuously improve – presents a crucial opportunity to address the overfishing of sharks and other global bycatch challenges.
Getting Scarce and Lure Shy: Impacts of Recreational Fishing on Coastal Northern Pike (Esox lucius) Abundance, Size Structure and Vulnerability to Angling
Authors: Roser Phillip , Radinger Johannes , Feldhege Fritz , Braun Marlon , Arlinghaus Robert 
Published: December 2024

ABSTRACTControlled experiments have shown that northern pike (Esox lucius) is able to develop lure avoidance, but whether such patterns exist in the wild is unknown. We assessed the impact of recreational fishing on a natural population of pike in the southern Baltic Sea, from samples of three pairs of partially protected areas (pMPA) and nearby unprotected sites. Pike were 2–4 times more abundant inside pMPAs than outside in sites open to fishing. The mean size of pike was not greater in pMPAs, but protected sites hosted more exceptionally large fish than sites open to fishing. Pike in sites with reduced recreational fishing effort were more aggressive to artificial lures. About one‐third of the catch rate differences among pMPAs and open sites could be attributed to lure shyness. Collectively, our work shows that recreational fisheries exploitation of coastal pike reduced abundance, truncated the size structure of the largest individuals, and contributed to fisheries‐induced timidity through reduced reactivity to lures.
The same, but different: The interactive effect of attributes of judges on judicial decision making and sentencing outcomes
Authors: Gansen Sarah 
Published: December 2024

AbstractIn this article, I consider whether certain attributes of a judge and, most importantly, the interaction effects of these characteristics affect the way judges decide cases and can explain disparities in sentencing outcomes. Using a supervised machine learning technique, the analysis uncovers some important effects not previously discussed in the extant literature. The results suggest that judges appointed by Republican Governors are most likely to give harsher sentences for all crimes but especially for felony and violent offences. Concerning crimes involving a high level of moral turpitude, judges get harsher as they age and men much more so than women.