bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic variation in fit note receipt and long-term conditions in south London
Authors: Dorrington Sarah , Carr Ewan , Stevelink Sharon A M , Dregan Alexandru , Whitney David , Durbaba Stevo , Ashworth Mark , Mykletun Arnstein , Broadbent Matthew , Madan Ira , Hatch Stephani , Hotopf Matthew 
Published: March 2020

ObjectivesIntroduced in the UK in 2010, the fit note was designed to address the problem of long-term sickness absence. We explored (1) associations between demographic variables and fit note receipt, ‘maybe fit’ use and long-term conditions, (2) whether individuals with long-term conditions receive more fit notes and are more likely to have the ‘maybe fit’ option selected and (3) whether long-term conditions explained associations between demographic variables and fit note receipt.MethodsData were extracted from Lambeth DataNet, a database containing electronic medical records of all 45 general practitioner (GP) practices within the borough of Lambeth. Individual-level anonymised data on GP consultations, prescriptions, Quality and Outcomes Framework diagnostic data and demographic information were analysed using survival analysis.ResultsIn a sample of 326 415 people, 41 502 (12.7%) received a fit note. We found substantial differences in fit note receipt by gender, age, ethnicity and area-level deprivation. Chronic pain (HR 3.7 (95% CI 3.3 to 4.0)) and depression (HR 3.4 (95% CI 3.3 to 3.6)) had the highest rates for first fit note receipt. ‘Maybe fit’ recommendations were used least often in patients with epilepsy and serious mental illness. The presence of long-term conditions did not explain associations between demographic variables and fit note use.ConclusionsFor the first time, we show the relationships between fit note use and long-term conditions using individual-level primary care data from south London. Further research is required in order to evaluate this relatively new policy and to understand the needs of the population it was designed to support.
The optimal level of windpower that could be regulated with Norway’s existing hydroreservoirs
Authors: Hirvijoki Eero 
Published: March 2020

AbstractThis study estimates the optimal level of wind-generated electricity production in Nordic countries’ market region given the existing hydroreservoirs of Norway to regulate the intermittency in wind-energy production and to meet the market demand. Using realized, scaled patterns for hourly wind production and electricity demand, we perform a series of numerical simulations and find a threshold value of approximately 90 TWh for annual wind production after which surplus and deficit in the production begin to accumulate significantly, weakening the utilization factor of wind installments. In light of the ambitious climate policies in the Nordic countries, and that the existing annual capacity of installed wind in the region is approximately 41 TWh, the Nordic governments should consider investing heavily in both national and international grid infrastructure to enable private sector to double the existing wind capacity in the market region.
Breakdown of the Linear Relationship between the Southern Hemisphere Hadley Cell Edge and Jet Latitude Changes in the Last Glacial Maximum
Authors: Kim Seo-Yeon , Son Seok-Woo 
Published: March 2020

AbstractA poleward displacement of the Hadley cell (HC) edge and the eddy-driven jet latitude has been observed in the Southern Hemisphere (SH) during the last few decades. This change is further projected to continue in the future, indicating coherent tropical and extratropical zonal-mean circulation changes from the present climate to a warm climate. Here we show that such a systematic change in the zonal-mean circulation change does not hold in a cold climate. By examining the Last Glacial Maximum (LGM), preindustrial (PI), and extended concentration pathway 4.5 (ECP4.5) scenarios archived for phase 3 of the Paleoclimate Modeling Intercomparison Project (PMIP3) and phase 5 of the Coupled Model Intercomparison Project (CMIP5), it is shown that while the annual-mean SH HC edge systematically shifts poleward from the LGM scenario to the PI scenario and then to the ECP4.5 scenario the annual-mean SH eddy-driven jet latitude does not. All models show a poleward jet shift from the PI scenario to the ECP4.5 scenario, but over one-half of the models exhibit no trend or even an equatorward jet shift from the LGM scenario to the PI scenario. This decoupling between the HC edge and jet latitude changes is most pronounced in SH winter when the Antarctic surface cooling in the LGM scenario is comparable to or larger than the tropical upper-tropospheric cooling. This result indicates that polar amplification could play a crucial role in driving the decoupling of the tropical and midlatitude zonal-mean circulation in the SH in a cold climate.
Interannual-to-Multidecadal Responses of Antarctic Ice Shelf–Ocean Interaction and Coastal Water Masses during the Twentieth Century and the Early Twenty-First Century to Dynamic and Thermodynamic Forcing
Authors: Kusahara Kazuya 
Published: March 2020

AbstractMuch attention has been paid to ocean–cryosphere interactions over the Southern Ocean. Basal melting of Antarctic ice shelves has been reported to be the primary ablation process for the Antarctic ice sheets. Warm waters on the continental shelf, such as Circumpolar Deep Water (CDW) and Antarctic Surface Water (AASW), play a critical role in active ice shelf basal melting. However, the temporal evolution and mechanisms of the basal melting and warm water intrusions throughout the twentieth century and the early twenty-first century have not been rigorously examined and are not fully understood. Here, we conduct a numerical experiment of an ocean–sea ice–ice shelf model forced with a century-long atmospheric reanalysis for the period 1900–2010. To begin with, we provide an assessment of the atmospheric conditions by comparing with available observation and show biases in warming and stronger westerly trends. Taking into account the limitation, we examine the interannual-to-multidecadal variability in the Antarctic ice shelf basal melting and the role of coastal water masses. A series of numerical experiments demonstrate that wind stress changes over the Southern Ocean drive enhanced poleward heat transport by stronger subpolar gyres and reduce coastal sea ice and cold-water formations, both of which result in an increased ocean heat flux into Antarctic ice shelf cavities. Furthermore, an increase of sea ice–free days leads to enhanced regional AASW contribution to the basal melting. This study demonstrates that changes in Antarctic coastal water masses are key metrics for better understanding of the ocean–cryosphere interaction over the Southern Ocean.
Role of Biofilms in Post-Tympanostomy Tube Otorrhea
Authors: Marom Tal , Habashi Nadeem , Cohen Robert , Tamir Sharon Ovnat 
Published: March 2020

Objective: Nearly half of children who undergo tympanostomy tube (TT) insertion may experience otorrhea following surgery. We sought to review the evidence for the role of bacterial biofilms in post-tympanostomy tube otorrhea (PTTO) and the accumulated experience regarding the preventive measures for biofilm formation/adhesion on TTs. Methods: English literature search for relevant MeSH keywords was conducted in the following databases: MEDLINE (via PubMed), Ovid Medline, Google Scholar, and Clinical Evidence (BMJ Publishing) between January 1, 1995, and December 31, 2019. Subsequently, articles were reviewed and included if biofilm was evident in PTTO. Results: There is an increased evidence supporting the role of biofilms in PTTO. Studies on TT design and material suggest that nitinol and/or silicone TTs had a lower risk for PTTO and that biofilms appeared in specific areas, such as the perpendicular junction of the T-tubes and the round rims of the Paparella-type tubes. Biofilm-component DNAB-II protein family was present in half of children with PTTO, and targeting this protein may lead to biofilm collapse and serve as a potential strategy for PTTO treatment. Novel approaches for the prevention of biofilm-associated PTTO include changing the inherent tube composition; tube coating with antibiotics, polymers, plant extracts, or other biofilm-resistant materials; impregnation with antimicrobial compounds; and surface alterations by ion-bombardment or surface ionization, which are still under laboratory investigation. Conclusions: Currently, there is no type of TT on which bacteria will not adhere. The challenges of treating PTTO indicate the need for further research in optimization of TT design, composition, and coating.
Presentation and Outcomes of Elderly Patients Undergoing Head and Neck Surgeries: A National Perspective
Authors: Al‐Qurayshi Zaid , Sullivan Christopher Blake , Schwalje Adam , Walsh Jarrett , Bayon Rodrigo , Tufano Ralph , Kandil Emad 
Published: March 2020

ObjectivesTo examine clinical profile and outcomes of elderly patients (65‐90 years) undergoing head and neck surgeries in the United States.Study DesignA retrospective cross‐sectional analysis.SettingThe Nationwide Readmissions Database, 2010 to 2015.Subjects and MethodsAdult (≥18 years) patients who underwent head and neck surgeries. Analysis included χ2 test and logistic analysis.ResultsA total of 113,602 and 32,580 patients <65 and ≥65 years old, respectively, were included. Patients ≥65 years old were more likely to have multiple comorbidities (62.8% vs 32.6%, P <. 001) and to present with head and neck cancer (19.8% vs 11.4%, P <. 001). The most common comorbidity was diabetes (21.0%). The most common cancer types by site were mouth (29.12%), thyroid (28.08%), and nonmelanoma skin cancer (13.22%). The percentage of geriatric patients who underwent head and neck surgeries increased from 21.8% in 2010 to 25.0% in 2015 (P <. 001). A total of 5450 (16.85%) patients developed postoperative complications, and the most common complications were pulmonary related (10.55%), bleeding (6.96%), acute renal failure (6.01%), and infection (3.97%). Blood transfusion was required in 3.53% of the patients. Readmission prevalence was 0.32%, and mortality risk was twice as likely (odds ratio, 2.05; 95% confidence interval, 1.77‐2.38; P <. 001). Independent risk factors of mortality were older age, multiple comorbidities, type of surgery, blood transfusion, and tracheostomy (P <. 05, each).ConclusionElderly patients currently represent 25% of patients admitted for head and neck surgery. This population should be provided with a different level of care due to a higher risk of complications and mortality.
The Effects of Steroids on Survival of Mouse and Human Tympanic Membrane Fibroblasts
Authors: Karnani David N. , Dirain Carolyn O. , Antonelli Patrick J. 
Published: March 2020

ObjectiveTympanic membrane (TM) fibroblast cytotoxicity of quinolone ear drops is enhanced by dexamethasone and fluocinolone. Hydrocortisone has not been evaluated. We aimed to assess the effects of these 3 steroids on mouse and human TM fibroblast survival.Study DesignIn vitro.SettingAcademic laboratory.Subjects and MethodsMouse and human TM fibroblasts were exposed to hydrocortisone, dexamethasone, or fluocinolone at concentrations in commercial ear drops (1%, 0.1%, or 0.025%, respectively) and at steroid potency equivalents (1%, 0.033%, or 0.0033%, respectively), or dilute ethanol (control), twice within 24 hours or 4 times within 48 hours for 2 hours each time. Cells were observed with phase‐contrast microscopy until the cytotoxicity assay was performed.ResultsMouse and human TM fibroblasts treated with any of the steroids had lower survival after 24 and 48 hours compared to control (all P <. 0001). After 24 hours, viability of mouse fibroblasts treated with the steroids was not different (P >. 05), while treatment with hydrocortisone decreased human TM fibroblast viability (P <. 0001). After 48 hours, at concentrations found in ear drops and at equivalent steroid potency, dexamethasone and fluocinolone had similar survival in mouse and human fibroblasts (all P >. 05), but hydrocortisone had lower survival in both mouse (P =. 02 and P <. 0001) and human (P <. 0001) fibroblasts. Phase‐contrast images mirrored the cytotoxicity findings.ConclusionSteroids found in commercial ear drops reduce survival of mouse and human TM fibroblasts. Hydrocortisone appears to be more cytotoxic than the more potent steroids, dexamethasone and fluocinolone. These findings should be considered when assessing clinical outcomes of ototopical preparations.
Onasemnogene Abeparvovec-xioi: Gene Therapy for Spinal Muscular Atrophy
Authors: Stevens Debra , Claborn Melanie K. , Gildon Brooke L. , Kessler Tiffany L. , Walker Cheri 
Published: March 2020

Objective: To review the efficacy and safety of onasemnogene abeparvovec-xioi (Zolgensma) in the treatment of spinal muscular atrophy (SMA). Data Sources: An English-language literature search of PubMed, MEDLINE, and Ovid (1946 to December 2019) was completed using the terms onasemnogene, AVXS-101, and spinal muscular atrophy. Manufacturer prescribing information, article bibliographies, and data from ClinicalTrials.gov were incorporated in the reviewed data. Study Selection/Data Extraction: All studies registered on ClinicalTrials.gov were incorporated in the reviewed data. Data Synthesis: Onasemnogene is the first agent for SMA utilizing gene therapy to directly provide survival motor neuron 1 ( SMN1) gene to produce SMN protein. Four publications of 1 clinical trial, 1 comparison study of treatment effects, and 1 combination therapy case series have been published. Relevance to Patient Care and Clinical Practice: Onasemnogene is a one time dose approved by the Food and Drug Administration for SMA patients <2 years old who possess mutations in both copies of the SMN1 gene. Conclusion: Onasemnogene appears to be an efficacious therapy for younger pediatric patients with SMA type 1. Concerns include drug cost and potential liver toxicity. Long-term benefits and risks have not been determined.
Primary Arthrodesis for Diabetic Ankle Fractures
Authors: Grote Caleb W. , Tucker William , Stumpff Kelly , Birt Mitchell C. , Horton Greg A. 
Published: March 2020

Background: Treatment of ankle fractures in patients with diabetes is associated with increased complication rates. Ankle arthrodesis is considered a salvage procedure after failed ankle fracture fixation, yet primary ankle arthrodesis has been proposed as a treatment option for patients with significant diabetes-related complications. To date, the characteristics of patients who undergo primary ankle arthrodesis and the associated outcomes have not been described. Methods: A retrospective review was performed of 13 patients with diabetes who underwent primary arthrodesis for traumatic ankle fracture. Patient demographics were characterized in addition to their diabetes complications, Adelaide Fracture in the Diabetic Ankle (AFDA) score, and fracture type. Outcomes assessed included reoperation rates, infection rates, wound complications, nonunion/malunion, amputation, and development of Charcot arthropathy postoperatively. Results: Patients who underwent primary arthrodesis had high rates of diabetes complications, average AFDA scores of 6.4, and high rates of severe injuries, including 38.5% open fractures and 69.2% fracture dislocations. The overall complication rate for primary arthrodesis of ankle fractures in diabetes patients was more than 75% in this cohort. Complications included a 38.5% reoperation rate, 38.5% infection rate, 53.8% wound complication rate, and 23.1% amputation rate. Despite a high nonunion rate at the attempted fusion sites, 89.9% of fractures healed and patients had a stable extremity. Conclusion: This review is the first to characterize the epidemiology and complications of diabetes patients undergoing primary ankle arthrodesis for ankle fractures. In this cohort, patients with multiple diabetic complications and severe injuries underwent primary arthrodesis, which led to an overall high complication rate. Further research is needed to determine the appropriate treatment option for these high-risk patients, and tibiotalocalcaneal stabilization without arthrodesis may be beneficial. Level of Evidence: Level IV, retrospective case series.
The effects of daily fasting hours on shaping gut microbiota in mice
Authors: Li Linghao , Su Yuxin , Li Fanglin , Wang Yueying , Ma Zhongren , Li Zhuo , Su Junhong 
Published: March 2020

Abstract
Background
It has recently been reported that intermittent fasting shapes the gut microbiota to benefit health, but this effect may be influenced to the exact fasting protocols. The purpose of this study was to assess the effects of different daily fasting hours on shaping the gut microbiota in mice. Healthy C57BL/6 J male mice were subjected to 12, 16 or 20 h fasting per day for 1 month, and then fed ad libitum for an extended month. Gut microbiota was analyzed by 16S rRNA gene-based sequencing and food intake was recorded as well.

Results
We found that cumulative food intake was not changed in the group with 12 h daily fasting, but significantly decreased in the 16 and 20 h fasting groups. The composition of gut microbiota was altered by all these types of intermittent fasting. At genus level, 16 h fasting led to increased level of Akkermansia and decreased level of Alistipes, but these effects disappeared after the cessation of fasting. No taxonomic differences were identified in the other two groups.

Conclusions
These data indicated that intermittent fasting shapes gut microbiota in healthy mice, and the length of daily fasting interval may influence the outcome of intermittent fasting.
Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs
Authors: Yun Sumin , Kim Woosuk , Kang Min Soo , Kim Tae Hyeong , Kim Yoonhwan , Ahn Jin-Ok , Choi Jung Hoon , Hwang In Koo , Chung Jin-Young 
Published: March 2020

Abstract
Background
Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.

Results
To assess the possibility of creating a reversible sensory neuropathy model using dogs, 150 mg/kg of PDX was injected subcutaneously into dogs for 7 days and body weight measurements, postural reaction assessments, and electrophysiological recordings were obtained. In addition, the morphology of dorsal root ganglia (DRG) and changes in glial fibrillary acidic protein (GFAP) immunoreactive satellite glial cells and ionized calcium-binding adapter molecule 1 (Iba-1) immunoreactive microglia/macrophages were assessed at 1 day, 1 week, and 4 weeks after the last PDX treatment. During the administration period, body weight and proprioceptive losses occurred. One day after the last PDX treatment, electrophysiological recordings showed the absence of the H-reflex in the treated dogs. These phenomena persisted over the four post-treatment weeks, with the exception of body weight which recovered to the pre-treatment level. Staining (CV and HE) results revealed significant losses of large-sized neurons in the DRG at 1 day and 1 week after PDX treatment cessation, but the losses were recovered at 4 weeks post-treatment. The Iba-1 and GFAP immunohistochemistry results showed pronounced increases in reactive microglia/macrophage and satellite glial cell at 1 day and 1 week, respectively, after the last PDX treatment, and thereafter, immunoreactivity decreased with increasing time after PDX treatment.

Conclusions
The results suggest that PDX-induced neuropathy is reversible in dogs; thus, dogs can be considered a good experimental model for research on neuropathy.
Mechanism of nutrition activity of a microgranule fertilizer fortified with proteins
Authors: Olbrycht Maksymilian , Kołodziej Michał , Bochenek Roman , Przywara Mateusz , Balawejder Maciej , Matłok Natalia , Antos Piotr , Piątkowski Wojciech , Antos Dorota 
Published: March 2020

Abstract
Background
A microgranule fertilizer was designed for localized fertilization of soil with controlled release of nutrients. The microgranule matrix was fortified with proteins, which were obtained from food industry byproducts or waste, i.e., whey protein from milk serum, soy protein from soy isolate and egg white protein from chicken egg white powder. The mechanism of the protein decomposition and migration of micro and macromolecule compounds through two different model soil systems was investigated. The potential of the protein fortified fertilizer for localized fertilization of the potted maize seeds was evaluated.

Results
The study revealed that proteins slowly diffused through soil with simultaneous degradation, which was accompanied with release of ammonia ions. The highest concentration of proteins and degradation products was found in a close vicinity of the microgranule. The microgranules were used as a local fertilizer for maize seeds in the pot experiments. The experiments confirmed statistically significant improvement in root density of maize plant compared to control group.

Conclusions
Byproducts or waste of food industry, such as the milk serum and soy can be used as a source of proteins that degrade in soil without a pretreatment. The degradation is accompanied with formation of ammonium ions, which can be utilized by plants as a nitrogen source. The fertilizer microgranule should be placed in a close vicinity to the plant seed, since the maximum of the protein concentration and ammonia ions is reached at a very close distance from the microgranule.
Chinese ASCVD risk equations rather than pooled cohort equations are better to identify macro- and microcirculation abnormalities
Authors: Li Qiaowei , Lin Fan , Gao Zhonghai , Huang Feng , Zhu Pengli 
Published: March 2020

Abstract
Background
We hypothesized that discriminating the early subclinical organ damage would serve as a great opportunity for prevention against atherosclerotic cardiovascular disease (ASCVD). Brachial-ankle pulse wave velocity (baPWV), low retinal vascular fractal dimension, and albuminuria are surrogates of subclinical vascular changes.

Methods
The aim of this study was to use Pooled Cohort Equations (PCE) and ASCVD risk equations derived from “Prediction for ASCVD Risk in China project (CHINA-PAR)” to observe the prevalence of macro- and microcirculation abnormalities. A total of 2166 subjects were involved. Characteristics were investigated using questionnaire and physical examinations. We calculated the urine albumin to creatinine ratio (UACR). The baPWV was measured using a fully automatic arteriosclerosis detector. The retinal vascular fractal dimension was measured by a semiautomated computer-based program. The 10-year ASCVD risk was estimated using the PCE and CHINA-PAR model.

Results
The cut-off values for the elevated baPWV were 2.82 and 2.92% in the PCE model and CHINA-PAR model, respectively, with nearly 85% sensitivity and an average specificity of 74%. For low retinal fractal dimension, at the cut-off point of 3.8%, we acquired an acceptable sensitivity of 66.27–68.24% and specificity of 62.57–67.45%. All the C-statistics presented a significant improvement from the PCE model to the CHINA-PAR model (P < 0.05). For all categories—net reclassification improvement (NRI) values were significant and clearly varied (0.329, 0.183, and 0.104, respectively) depending on the cut-off set at 3%.

Conclusion
Our study demonstrated that the CHINA-PAR equations rather than PCE could provide better identification of macro- and microcirculation abnormalities. A lower cut-off point for the subclinical vascular changes may be selected in a population from southeast China.