bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity and Reliability of the Portuguese-performance Assessment of Self-care Skills (P-PASS) for Portuguese Individuals With Disabilities
Authors: Ferreira Pedro L , Simões Ana Lúcia , Dourado Marília , Holm Margo B. , Rogers Joan C. 
Published: August 2020

Abstract
Background: Due to the increasing need to measure health outcomes and to ensure a more independent life, it is essential to validate instruments capable of assessing the functionality of activities of daily living. The Performance Assessment of Self-Care Skills (PASS), based on three assessment parameters (independence, safety and adequacy), allows health professionals to delineate their interventions more effectively according to the needs of each client. The purpose of this study was to create a Portuguese version of the PASS (P-PASS) and to measure the performance of people with disabilities. Methods. Linguistic validation was performed through the translation/back-translation procedure. Next, the scale to be completed by health professionals was submitted to a clinical review by a panel of experts. Subsequently, it was applied to 98 people with physical and/or cognitive disabilities. The data collected were then analyzed and the results evaluated in accordance with the three PASS parameters. The results were also analyzed in terms of age and gender. Results. To create the Portuguese version, one task was removed from the original PASS and seven tasks were combined or adapted. Task independence had the highest scores and adequacy the lowest. In terms of reliability, the P-PASS revealed almost perfect levels of agreement between observers, except for the adequacy parameter of the ‘bed mobility’ task that showed moderate agreement. In general, the original structure of the PASS was replicated in the Portuguese version. Men presented greater independence than women in the tasks of ‘bill paying by ATM’ and ‘changing TV command batteries.’ Participants under 60 years of age had the highest scores overall. Conclusions. The combination or adaptation of some items to be more culturally relevant is a valid procedure that has been used by other authors during the validation of PASS items. The results obtained by P-PASS showed comparable scores with the original PASS and with other translated/adapted versions. The P-PASS is a valid and reliable scale for the Portuguese population, enabling more effective measurement of health outcomes.
si-SNHG5-FOXF2 Inhibits TGF-β1-induced Fibrosis in Human Primary Endometrial Stromal Cells by Wnt/β-catenin Signaling Pathway
Authors: Liu Limin , Chen Guobin , Chen Taoliang , Shi Wenjuan , Hu Haiyan , Song Kaijing , Huang Ruichun , He Yuanli , Cai Huihua 
Published: August 2020

Abstract
Background: Intrauterine adhesions (IUAs) are manifestations of endometrial fibrosis characterized by inflammation and fibrinogen aggregation in the extracellular matrix (ECM). The available therapeutic interventions for IUA are insufficiently effective in the clinical setting for postoperative adhesion recurrence and infertility problems. In this study, we investigated si-SNHG5-FOXF2 can serve as a molecular mechanism for inhibition of IUA fibrosis ex vivo.Methods: FOXF2, TGF-β1 and collagens expression levels were measure by a Microarray sequencing analysis in three normal endometrium group and six IUA patients. We induced primary HESCs into MFs to develop an IUA cell model with various concentrations of TGF-β1 at various times. Downstream target genes for FOXF2 were screened by chromatin immunoprecipitation combined with whole- genome high-throughput sequencing (ChIP-seq). We investigated ECM formation, cell proliferation and Wnt/β-catenin signaling pathway-related proteins in primary HESCs with FOXF2 downregulation by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), western blotting (WB), immunohistochemistry (IHC), Flow cytometry, EdU and CCK8 assays. We identified lncRNA SNHG5 as the upstream regulatory gene of FOXF2 through RNA immunoprecipitation (RIP), RNA-pulldown and FISH. Finally, we examined FOXF2 expression, ECM formation, cell proliferation and Wnt/ β-catenin signaling pathway-related proteins in primary HESCs with FOXF2 downregulation.Results: FOXF2 was highly expressed in endometrium from patients with IUA. Treatment of primary HESCs with 10ng / ml TGF-β1 for 72 h was found to be most effective for developing an IUA cell model. FOXF2 regulated multiple downstream target genes including collagen, VIM and cyclin D2/DK4 by ChIP-seq and ChIP-PCR. FOXF2 downregulation inhibited TGF-β1-mediated primary HESC fibrosis including ECM formation, cell proliferation and Wnt/β-catenin signaling pathway-related proteins expressions. We identified lncRNA SNHG5 as an upstream gene that directly regulated FOXF2 by RIP-seq, qRT-PCR, WB and FISH. SNHG5 downregulation suppressed FOXF2 expression in the IUA cell model, resulting in synergistic repression of Wnt/β-catenin signaling pathway activation and thereby altering TGF-β1-mediated ECM aggregation in endometrial stromal cells ex vivo. Conclusions: Regulation of the Wnt/β-catenin signaling pathway and ECM formation by si-SNHG5-FOXF2 effectively inhibited the profibrotic effect of TGF-β1 on primary HESCs. It can provide a molecular basis for antagonizing TGF-β1-mediated fibrosis in primary HESCs.
Development of the Gait Outcomes Assessment List for Lower Limb Differences (GOAL-LD) Questionnaire: A Patient and Parent Reported Outcome Measure for Pediatric Lower-limb Deformity
Authors: Dermott Jennifer A , Wright Virginia , Salbach Nancy M , Narayanan Unni G 
Published: August 2020

Abstract
Purpose: To develop a priority-based patient /parent reported outcome measure for children with lower-limb differences (LD) by adapting the Gait Outcomes Assessment List (GOAL) questionnaire. Methods: Guided by a conceptual framework of patient priorities, the GOAL questionnaire was iteratively modified and its sensibility evaluated by field-testing it on children with LD and their parents. Cognitive interviews were conducted with a subgroup of these children, and an e-survey administered to a multidisciplinary group of health care professionals with expertise in paediatric LD. Findings were integrated to create the final version of the GOAL-LD. Results: Twenty-five children, 20 parents, and 31 healthcare professionals evaluated the content and sensibility of the GOAL, with an emphasis on the relevance and importance of the items to patients’ health related quality of life (HRQL). This resulted in the retention of 26 of the original 50 items, elimination of 12, modification of 12, and addition of seven new items. The new 45-item GOAL-LD questionnaire was shown to be sensible and its content deemed important. Conclusion: The GOAL-LD questionnaire has a high level of face and content validity, and sensibility. It comprehensively captures the HRQL goals and outcomes that matter to children with LD and their parents. Following further psychometric evaluation, the GOAL-LD may serve as a much needed patient and parent reported outcome measure for this population.
Modified Silicone Stent in the Treatment of Bronchopleural Fistula: Clinical Observation of 17 Cases
Authors: Zeng Junli , Wu Xuemei , Chen Zhide , Zhang Meihua , Ke Mingyao 
Published: August 2020

Abstract
Objective: Bronchopleural fistula is a rare but life-threatening event with limited therapeutic options. Aim of our study is to investigate the efficacy and safety of the modified silicone stent in patients with bronchopleural fistula.Method: Between March 2016 and April 2020, we retrospectively collected 17 patients with bronchopleural fistula and who underwent bronchoscopic placement of the modified silicone sten. The Y-shaped stent was tailored and sutured manually. The initial success, clinical success, the cured rate and complications were recorded. Results: Placement of the modified silicone stent was successful in 16 patients on first attempt (initial success rate was 94.1%). The median follow-up time was 107(rang, 5-431) days. The amelioration of respiratory symptoms was reported in all patients. There were 14 patients with empyema, the daily drainage was significantly decreased in 11 patients over time, and the purulent fluid completely disappeared in six patients. The clinical success rate was 76.5%. There were seven stents was removed during follow-up, four (26.7%) removed for cured fistula, two for the severe proliferation of granulation tissue and one for the dislocation of stent. No severe adverse events of stent migration and suture dehiscence happened. There were three cases were lost to follow-up and seven patients succumbed. The cause of death included progression of primary malignance, the uncontrolled infection, myocardial infarction and left heart failure.Conclusion: The modified silicone stent may be an effective and safe option for bronchopleural fistula patients in whom the conventional therapy is inappropriate and contraindicated.
Triple Stapling Resection and J pouch anal Stapling Anastomosis for Ulcerative Colitis
Authors: Kawahara Hidejiro , Omura Nobuo , Akiba Tadashi 
Published: August 2020

Abstract
Background: In 2017, we reported laparoscopic total proctocolectomy with J pouch anal anastomosis, which was created at the dentate line by our original procedure using staplers, Triple Stapling Resection and J pouch Anal Stapling Anastomosis (TSRJASA), for ulcerative colitis (UC) patients. UC patients have undergone TSRJASA since it was introduced in our institution. However, the feasibility and usefulness of TSRJASA for UC patients has not been elucidated.Methods: From January 2014 to December 2018, fourteen patients with ulcerative colitis, including three cases of concomitant cancer, who underwent TSRJASA were enrolled in this study. Anal manometry was performed using the Pock Monitor GMMS-100 system (STAR MEDICAL, INC., Tokyo, Japan) one year and two years after surgery. Maximum resting pressure, maximum squeeze pressure, and the length of the high-pressure zone were measured. Fecal incontinence was evaluated using the Wexner incontinence questionnaire.Results: J pouch anal anastomosis was created at the dentate line in all patients. In a manometric examination two years after surgery, maximum resting pressure was 75.3 (54-88) mmHg, maximum squeeze pressure was 125.0 (90-160) mmHg, and the length of the high-pressure zone was 39.6 (35-42) mm. Wexner score was 2.8 (1-4).Conclusion: TSRJASA seems to be a useful procedure for UC patients given its acceptable defecation function.
D-dimers at hospital admission for COVID-19 are associated with in hospital mortality independently of venous thromboembolism: Insight from a French multicenter cohort study
Authors: Chocron Richard , Duceau Baptiste , Gendron Nicolas , Ezzouhairi Nacim , Khider Lina , Trimaille Antonin , Goudot Guillaume , Weizman Orianne , Alsac Jean Marc , Pommier Thibault , Bory Olivier , Cellier Joffrey , Philippe Aurélien , Geneste Laura , Abdallah Iannis Ben , Panagides Vassili , Batti Salma El , Marsou Wassima , Juvin Philippe , Deney Antoine , Messas Emmanuel , Attou Sabir , Planquette Benjamin , Mika Delphine , Gaussem Pascale , Fauvel Charles , Diehl Jean-Luc , Pezel Theo , Mirault Tristan , Sutter Willy , Sanchez Olivier , Bonnet Guillaume , Cohen Ariel , Smadja David M. 
Published: August 2020

Abstract
Background: Coronavirus disease 2019 (COVID-19) has been associated with coagulation disorders, in particular high levels of D-dimers, and increased frequency of venous thromboembolism (VTE). We explore the association between D-dimers at admission and in-hospital mortality in hospitalized COVID-19 patients with or without symptomatic VTE.Methods: From February 26 to April 20, 2020, D-dimer level at admission and outcomes of patients hospitalized for COVID-19 in medical wards (in-hospital mortality or VTE) were retrospectively analyzed in a multicenter study in 24 French hospitals.Results: Among 2878 patients enrolled in the study, 1154 (40.9%) patients had D-dimer measurement at admission. A receiver operating characteristic (ROC) curve analysis identified D-dimer level above 1128 ng/mL as the optimum cutoff value to predict in-hospital mortality (Area Under the Curve of 64.9% (95% CI 0.60–0.69) with a sensitivity of 71.1% (95% CI 0.62–0.78) and a specificity of 55.6% (95% CI 0.52–0.58) that not differ in the subgroup of patients with VTE during hospitalization. Among 609 (52.8%) patients with D-dimers level < 1128 ng/mL at admission, only 35 (5.7%) deaths occurred during hospitalization. After adjustment, in a cox proportional hazard and logistic regression models, D-dimers above 1128 ng/mL at admission were also associated to a worth prognosis with a OR of 3.07 (95% CI 2.05–4.69, p < 0.001) and an unadjusted hazard ratio of 2.11 (95%CI 1.31–3.4, p < 0.01).Conclusions: D-dimer level over 1128 ng/mL is a relevant predictive factor for in-hospital mortality in COVID-19 hospitalized patients in medical ward, regardless the occurrence of VTE during hospitalization.
A Comprehensive Analysis of Protein Data Bank reveals Low Desolvation Penalty in π-Cation System
Authors: Yang Jing-Fang , Wang Meng-Yao , Wang Di , Li Jing-Yi , Hao Ge-Fei , Li Qing X. , Yang Guang-Fu 
Published: August 2020

Abstract
Cation-π interactions widely exist between ligand-protein interfaces, attracting much attention in molecular recognition in recent years. Interactions named cation-π and π-cation (cationic vs arene small molecular ligands) shall be separately considered in drug and pesticide design process. The two interactions involved in ligands and protein pockets may differ in energy features and therefore offers significant inspiration for drug and pesticide design. However, an in-depth study on differences between cation-π and π-cation systems from an energy perspective is still lacking. In this study, we calculated and compared cation-π and π-cation systems in terms of physicochemical properties of ligand/protein and solvation effect. It seems that the desolvation penalty of the cation-π systems was relatively higher than the π-cation pairs, even though these interactions both can improve the ligand activity. This is the reason for evolution converged on π-cation interactions in the cation-π-mediated proteins. The π-cation interaction facilitating the inhalation of ligand to the pocket may provide a new sight for the molecular design of pharmaceuticals and pesticides.
Multidimensional Item Response Theory to Assess Psychological Properties of GHQ-12 in School Children Parents
Authors: Haem Elham , Doostfatemeh Marziyeh 
Published: August 2020

Abstract
Background: Multidimensional item response theory (MIRT) model provides an ideal foundation to assess psychological properties of a questionnaire designed with multidimensional structure. This study aims to present the first use of MIRT models to investigate psychological properties of GHQ-12. Methods: A total of 1104 school children parents completed the Persian version of GHQ-12 questionnaire. A MIRT model was applied to model observed scores for each GHQ-12 item as a function of the subject’s latent traits while taking into account the correlation between dimensions of the questionnaire. The goodness of fit indices were reported and items fit were assessed. Individual items were described in detail through item characteristic curves and the amount of information carried by different items were presented using information curves. Results: The MIRT analysis of the 12 item GHQ successfully demonstrated two factor structure corresponding to psychological distress and social dysfunction. The model showed all items were fitted adequately. Items varied in their discrimination ranged from 0.86 to 2.35 and 1.18 to 2.41 for psychological distress and social dysfunction, respectively. Moreover, item 8 and item 2 provided the least information in psychological distress and social dysfunction dimensions, respectively. Conclusions: The developed framework to evaluate psychological properties of GHQ-12 can be a suitable alternative to traditional approaches and also unidimensional IRT models which its use have been restricted due to multidimensional structure of the questionnaire.
Predicting Quality of Life and Mental Health During the First Year After Trauma Using Radial Basis Function Neural Network&nbsp;
Authors: Sehat Zahra , Fakharian Esmaeil , Sehat Mojtaba , Omidi Abdollah 
Published: August 2020

Abstract
Background: This study aimed to investigate the quality of life (QOL) and mental health (MH) post-trauma in the population over 15 years. Methods: A cross-sectional population-based study, the cluster sampling method was used and 3880 people were interviewed randomly selected individuals between over 15 years in each household in the city of Kashan. Data were analyzed using chi-square, t-test. After data collection, a radial basis function neural network (RBFNN) architecture is exploited to predict the QOL category and MH status after traumatic injuries. Results :The rate of trauma was 70.64 (62.60-78.70) in 1000 annually, and 77.73% were male. 38.3% of people with trauma have suspected of having mental disorder and 53.3% of people with injury were in good condition of QOL. The risk of suspected MH disorders in people with trauma during the last year was 1.2(0.96-1.61), and the risk of bad QOL was 2.6(1.8-3.7). The obtained results reveal that the RBFNN model can predict the QOL category and MH status with a high level of accuracy (maximum 1% predicting error). Conclusion :This study reveals several parameters associated with the MH and QOL after trauma. This parameter can be used in prediction outcomes and used to evaluate the care of people with injury. It can also be concluded that the RBFNN predictor can be used for predicting the QOL category and MH status with reasonable authenticity, efficiency, and accuracy.
Age-Specific Crisis Awareness Survey for Coronavirus Disease 2019 (COVID-19): How Much Do You Think You Should Pay for Hypothetical Prophylactic Vaccine and Therapeutic Drug for COVID-19?
Authors: Kawahara Takashi , Yao Masahiro , Uemura Hiroji 
Published: August 2020

Abstract
BACKGROUND: The spread of coronavirus disease 2019 (COVID-19) has been a worldwide phenomenon with 2,063,161 people infected and 136,938 deaths globally as of April 16, 2020. This study conducted a chronological survey of crisis awareness regarding COVID-19 within different age groups.METHODS: An internet-based survey was performed of healthy Japanese adults to investigate the value of a hypothetical prophylactic vaccine and therapeutic drug for COVID-19 in each age group. The survey was conducted on Friday of each week commencing from February 14, 2020 to April 10, 2020. At certain times or events such as when the government released major announcements or when there was a rapid increase in the number of infected individuals, a similar survey was conducted on an additional 1,200 individuals per week.RESULTS: A total of 12 surveys, including weekly surveys spanning over 9 weeks, were conducted, and a total of 19,113 samples from 12,254 individuals were obtained. The mean price for a hypothetical prophylactic vaccine was 2876.3 JPY (26.9 USD) at the first survey and was significantly increased to 3357.4 JPY (31.4 USD) for the most recent survey (p < 0.0001). CONCLUSIONS: Though the percentage of those who will not pay were higher in young age group than in elderly age group, the percentage of those who will pay more than standard costs of influenza vaccine or treatment drugs were same between each aging group.
Adolescent-Caregiver Relationships and Mental Health Outcomes Among Adolescents Living with HIV: A Prospective Cohort Study in South Africa
Authors: Shenderovich Yulia , Boyes Mark , Esposti Michelle Degli , Casale Marisa , Toska Elona , Roberts Kathryn J. , Cluver Lucie 
Published: August 2020

Abstract
Background Mental health problems may impact adherence to anti-retroviral treatment, retention in care, and consequently the survival of adolescents living with HIV. The adolescent-caregiver relationship is an important potential source of resilience. However, there is a lack of longitudinal research in sub-Saharan Africa on which aspects of adolescent-caregiver relationships can promote mental health among adolescents living with HIV. We draw on a prospective longitudinal cohort study undertaken in South Africa to address this question.Methods The study traced adolescents aged 10-19 initiated on antiretroviral treatment in government health facilities (n = 53) within a health district of the Eastern Cape province. The adolescents completed standardised questionnaires during three data collection waves between 2014 and 2018. We used within-between multilevel regressions to examine the links between three aspects of adolescent-caregiver relationships (caregiver supervision, positive caregiving, and adolescent-caregiver communication) and adolescent mental health (depression symptoms and anxiety symptoms), controlling for potential confounders (age, sex, rural/urban residence, mode of infection, household resources), n=926 adolescents. Results Improvements in caregiver supervision were associated with reductions in anxiety (0.98, 95% CI 0.97-0.99, p=0.0002) but not depression symptoms (0.99, 95% CI 0.98-1.00, p=.151), while changes in positive caregiving were not associated with changes in mental health symptoms reported by adolescents. Improvements in adolescent-caregiver communication over time were associated with reductions in both depression (IRR=0.94, 95% CI 0.92-0.97, p<.0001) and anxiety (0.91, 95% CI 0.89-0.94, p<.0001) symptoms reported by adolescents. Conclusions Findings highlight open and supportive adolescent-caregiver communication and good caregiver supervision as potential factors for guarding against mental health problems among adolescents living with HIV in South Africa. Several evidence-informed parenting programmes aim to improve adolescent-caregiver communication and caregiver supervision, and their effect on depression and anxiety among adolescents living with HIV should be rigorously tested in sub-Saharan Africa. How to improve communication in other settings, such as schools and clinics, and provide communication support for caregivers, adolescents, and service providers through these existing services should also be considered.