bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of time parameter proportionality ratios in large catchments: Case study of the Modder‐Riet River Catchment, South Africa
Authors: Allnutt Christopher E. , Gericke Ockert J. , Pietersen Jaco P. J. 
Published: July 2020

AbstractCatchment response time parameters, for example, the time of concentration (TC), lag time (TL), and time to peak (TP) are fundamental to event‐based design flood estimation in ungauged catchments. Hydrological literature often fails to clearly differentiate between the seven different time parameter definitions interchangeably used in practice and consequently, proportionality ratios are commonly applied. This article aims to investigate and establish the suitability of the currently recommended time parameter definitions and proportionality ratios for small catchments in larger sub‐catchments exceeding 50 km2 by using an automated hyetograph–hydrograph analysis tool. The time parameter estimates proved to be highly variable, but the average time parameter proportionality ratios proved to be less significant and in all the sub‐catchments, it was confirmed that the average proportionality ratios equal unity, that is, TC ≈ TL ≈ TP. Hence, the currently recommended TC:TL proportionality ratios of 1.417 and 1.667, are respectively not applicable at larger catchment levels. The establishment of unbiased empirical time parameter equations would remain an international challenge if the misinterpretation of the different time parameter definitions and use of incorrect time parameter proportionality ratios continue; hence, the results from this study, as well as others, should be considered for further investigation and/or implementation.
Impacts of urban drainage systems on stormwater hydrology: Rocky Branch Watershed, Columbia, South Carolina
Authors: Ress Logan D. , Hung Chen‐Ling J. , James L. Allan 
Published: July 2020

AbstractIncreases in impervious surfaces and land‐use changes associated with urbanization have long been the focus of urban hydrological research. However, studies and calculations that consider impervious surfaces alone do not encompass all factors that influence urban hydrologic response, as alternative urban structures may have a substantial effect on stormflow. This study examines several descriptors to improve estimations of hydrologic impacts of urbanization in small watersheds. Configurations of drainage densities that include storm sewers were computed for the highly urbanized Rocky Branch Watershed. Storm sewer configurations resulted in an approximate tripling of the drainage density. In addition, rainfall and stormflow data were analyzed to compare the hydrologic response of two subcatchments with varying percentages of impervious areas and drainage densities. The subcatchment with a higher percentage of impervious area produced significantly (p < .01) higher runoff volumes with an average runoff coefficient of 0.446, while the subcatchment with higher storm sewer densities displayed significantly shorter lag times of 9 min. In this case, the percentage of impervious area increased the volume of runoff but, storm sewer densities accelerated hydrologic responses, suggesting that hydrologically relevant metrics should be considered to accurate assess flood risk alternatives.
National Geriatric Network Rapidly Addresses Trainee Telehealth Needs in Response to COVID‐19
Authors: Nearing Kathryn A. , Lum Hillary D. , Dang Stuti , Powers Becky , McLaren Jaye , Gately Megan , Hung William , Moo Lauren 
Published: July 2020

BACKGROUND/OBJECTIVESCoronavirus disease 2019 (COVID‐19) has pushed many geriatric healthcare providers to attempt video visits for the first time. Although the Veterans Health Administration (VA) is a pioneer in telemedicine, rapid shifts to nearly exclusive use of telehealth for healthcare delivery and changes regarding trainee engagement in telehealth served as the impetus for rapidly assessing telehealth training needs.DESIGNNational needs assessment (online survey) of associated health trainees and medical fellows affiliated with Geriatric Research Education and Clinical Centers (GRECCs).SETTINGNational GRECC network ‐‐ 20 VA centers of excellence focused on supporting Veterans as they age. Each GRECC is affiliated with a school of medicine at a major university.PARTICIPANTSTrainees (n = 89) representing 12 disciplines.RESULTSTwo‐thirds of participants had received some telehealth training. However, most had never done a video‐to‐home visit, and, regardless of telehealth experience, they reported low confidence. Based on open‐ended questions exploring training needs, educational resources were rapidly developed and disseminated.INTERVENTIONWithin 1 week of the assessment, a nuts‐and‐bolts guide regarding remote access, technology requirements, video‐conferencing platforms, and managing emergencies was sent to the national network of GRECC associate directors for education for dissemination among discipline‐specific training directors at their sites. This resource was subsequently submitted to the national VA COVID Strong Practices SharePoint site. An interdisciplinary team of geriatric specialists with extensive video‐to‐home experience also organized a national webinar that peaked at just over 700 participants. GRECC Connect, a network of geriatric specialty teams funded to improve care access for rural older veterans using telehealth and associated health training programs at each GRECC facilitated rapid development and dissemination of both resources.CONCLUSIONWe quickly identified and responded to telehealth training needs of geriatrics trainees to optimize care for rural older adults as part of a rapid response to COVID‐19. Although the webinar and nuts‐and‐bolts resources were developed within the VA context, they have demonstrated high demand and broader applicability. Results should continue to inform curriculum development efforts to address telehealth training gaps within and outside the VA.
Head Repositioning during Neurointerventional Procedures to Optimize Biplanar Imaging
Authors: Dowlati Ehsan , Zhou Tianzan , Stewart Jeffrey , Felbaum Daniel R. , Liu Ai‐Hsi , Mai Jeffrey C. , Armonda Rocco A. 
Published: July 2020

ABSTRACTBACKGROUND AND PURPOSEHead positioning is an important aspect for surgical planning in any cranial procedure. However, in neurointerventional cases, this is an afterthought due to advances in biplane imaging. We aim to present that the concept of head positioning may be applied to neurointerventional procedures to obtain optimal working projections to aide in the treatment of neurovascular pathology.METHODSThe operative log of the senior author was reviewed between 2016 and 2019. Seventeen patients were identified who required readjustment of head position to allow for ideal working projection during treatment. The reports and imaging of these patients were reviewed and categorized based on repositioning adjustments applied.RESULTSThree specific head adjustments were performed to obtain working projections using biplanar angiography: head flexed position, head extended position, or extended‐tilt positioning. All patients underwent endovascular coiling treatment for a variety of intracranial aneurysms.CONCLUSIONIn select cases, ideal views of vascular pathology can be difficult to obtain due to limitations of biplane rotation or patient‐specific anatomy. Simple maneuvers in head positioning can be done to achieve better working projections for optimized endovascular treatment.
The effect of botulinum toxin A on patients with persistent idiopathic dentoalveolar pain—A systematic review
Authors: Dawson Andreas , Dawson Jenny , Ernberg Malin 
Published: July 2020

AbstractBackgroundIt has been suggested that botulinum toxin A (BONT‐A) is a safe and effective treatment in relieving pain in patients with persistent idiopathic dentoalveolar pain (PIDP).ObjectivesThis study aimed to systematically evaluate all the available studies investigating the pain‐relieving effects of BONT‐A in patients with PIDP.MethodsA systematic search with specific search terms was made in PubMed, Web of Science and Scopus. Two authors screened titles and abstracts and selected eligible studies for inclusion in the systematic review. The quality of the studies was evaluated by the 12 items Quality Assessment Tool for Observational studies (Pre‐Post) Studies with No Control Group, and the level of evidence was assessed according to GRADE.ResultsThree observational studies of 3695 identified were included (445 overlapping studies; 3247 excluded studies). All studies were uncontrolled observational studies investigating the pain‐relieving effect of BONT‐A in patients with PIDP. The included studies had a fair quality (moderate risk of bias) and insufficient level of evidence. The pain reducing effect by BONT‐A injections was in average 50% or more in two studies, in one study 3 out of 4 patients became almost pain free.ConclusionsThis systematic review shows that presently the level of scientific evidence is insufficient to evaluate the pain‐relieving effect of BONT‐A injections in patients with PIDP. There are indications that BONT‐A injections could be a possible management option for patients with PIDP that seems to be safe and with few adverse events. There is a need for well‐designed placebo‐controlled, double‐blind RCTs.
Maryland dentists' perceptions and attitudes toward dental therapy
Authors: Davis Anna L. , Zare Hossein , McCleary Rachael , Kanwar Oshin , Tolbert Elliott , Gaskin Darrell J. 
Published: July 2020

AbstractObjectivesTo learn dentists' perceptions, attitudes, and concerns about the problems of access to oral health care for low income and rural Marylanders and to ascertain whether the dentists believe dental therapy is a viable solution.MethodsWe conducted three focus group discussions of 27 dentists during August and September 2018 in three locations in urban and rural areas of Maryland.ResultsFocus group participants felt that problems with access to dental care for low income and rural Marylander were not due to a shortage of dental providers. They believed there are more than enough dentists in the state. Access problems in Maryland are due in large part to inadequate insurance coverage and low oral health literacy. With the exception of one participant, the dentists would not use dental therapists in their practices to expand access.ConclusionsMaryland dentists in our focus group strongly oppose the use of dental therapists to address the state's unmet oral health care needs. Any effort to expand the state's dental workforce using dental therapists must address Maryland dentists' concerns and opinions.
Treatment outcomes in hepatitis C virus genotype 1a infected patients with and without baseline NS5A resistance‐associated substitutions
Authors: Dietz Julia , Vermehren Johannes , Matschenz Katrin , Buggisch Peter , Klinker Hartwig , Schulze zur Wiesch Julian , Hinrichsen Holger , Peiffer Kai‐Henrik , Graf Christiana , Discher Thomas , Trauth Janina , Schattenberg Jörn M. , Piecha Felix , Mauss Stefan , Niederau Claus , Müller Tobias , Neumann‐Haefelin Christoph , Berg Christoph P. , Zeuzem Stefan , Sarrazin Christoph ,   European HCV Resistance Study Group
Published: July 2020

AbstractBackground & AimsThe presence of baseline resistance‐associated substitutions (RASs) reduced sustained virologic response (SVR) rates in chronic hepatitis C virus (HCV) genotype 1a infected patients treated with Elbasvir/Grazoprevir (EBR/GZR). This study aimed to evaluate the frequency of NS5A RASs and treatment outcomes in patients for whom EBR/GZR was intended.MethodsWe sequenced NS5A in 832 samples from German genotype1a‐infected DAA‐naïve patients population‐based, which were collected in the European Resistance Database. Treatment outcomes and clinical parameters were evaluated in 519 of such patients retrospectively.ResultsOverall, 6.5% of patients harboured EBR‐specific NS5A RASs at baseline, including Q30H/R (3.3%), L31M (1.8%), Y93H (1.6%) and other individual variants. Antiviral treatment, including EBR/GZR, was initiated in 88% of the patients. In the absence of RASs, the majority of patients received EBR/GZR for 12 weeks (57%) and the SVR rate was 97% compared to 99% SVR achieved using other DAA regimens (LDV/SOF ± RBV, G/P, PrOD + RBV, VEL/SOF). Various regimens were used in the presence of RASs and SVR rates were high following treatment with LDV/SOF (100%), G/P (83%), PrOD/RBV (100%), VEL/SOF (100%), SMV/SOF (100%) and EBR/GZR + RBV for 16 weeks (100%). However, two patients received EBR/GZR for 16 weeks without RBV and one relapsed.ConclusionsEBR/GZR treatment with or without RBV for 12 or 16 weeks according to a baseline RAS analysis was highly effective with ≥97% SVR in patients with genotype 1a. EBR/GZR without RBV should be avoided in patients with RASs. High SVR rates were also achieved using other 8‐ or 12‐week DAA regimens.
Breastfeeding promotion on Twitter: A social network and content analysis approach
Authors: Moukarzel Sara , Rehm Martin , Daly Alan J. 
Published: July 2020

AbstractThe importance of breastfeeding for maternal and infant health is well‐established, yet complex and intertwined sociocultural barriers contribute to suboptimal breastfeeding rates in most countries. Large‐scale campaigns for evidence dissemination and promotion through targeted interventions on social media may help overcome some of these barriers. To date, most breastfeeding research on social media only focuses on content analysis, and there remains limited knowledge about the social networks of online communities (who interacts with whom), influencers in the breastfeeding space and the diffusion of evidence‐based knowledge. This study, grounded in social network theory, aims to better understand the breastfeeding communication landscape on Twitter including determining the presence of a breastfeeding network, communities and key influencers. Further, we characterize influencer interactions, roles and the content being shared. The study revealed an overall breastfeeding social network of 3,798 unique individuals (users) and 3,972 tweets with commonly used hashtags (e.g., #breastfeeding and #normalizebreastfeeding). Around one third of users (n = 1,324, 34%) exchanged pornographic content (PC) that sexualized breastfeeding. The non‐PC network (n = 2,474 users) formed 144 unique communities, and content flowing within the network was disproportionately influenced by 59 key influencers. However, these influencers had mostly inward‐oriented interaction (% composition, E‐I index: 47% professionals, −0.18; 41% interested citizens, −0.67; 12% companies, −0.18), limiting opportunities for evidence‐based dissemination to the lay public. Although more tweets about peer‐reviewed research findings were sent compared with tweets about nonevidence‐based lay recommendations, our findings suggest that it is the lay public who often communicated findings, which may be overcome through a targeted social network‐based intervention.
Overexpression of RRM2 is related to poor prognosis in oral squamous cell carcinoma
Authors: Wang Shuo , Wang Xiao‐Long , Wu Zhi‐Zhong , Yang Qi‐Chao , Xiong Hong‐Gang , Xiao Yao , Li Hao , Sun Zhi‐Jun 
Published: July 2020

AbstractObjectivesRibonucleotide reductase M2 (RRM2) is a rate‐limiting enzyme involved in DNA repair and synthesis. This study aimed to investigate the expression level, clinicopathological significance, and prognostic value of RRM2 in oral squamous cell carcinoma (OSCC).Materials and methodsHuman OSCC tissue microarrays were used to detect the expression of RRM2, cancer stem cell (CSC) markers CD44 and aldehyde dehydrogenase 1 (ALDH1), and the epithelial–mesenchymal transition (EMT) marker Slug. The correlation of RRM2 expression with clinicopathological parameters was evaluated. The effects of RRM2 on cell proliferation, migration, and apoptosis were investigated.ResultsCompared with normal and dysplastic tissues, the expression of RRM2 in human primary OSCC was significantly increased, and its overexpression was correlated with advanced pathological grade. The overall survival rate of patients with high RRM2 expression was lower than that of patients with low RRM2 expression. The overexpression of RRM2 was significantly associated with OSCC recurrence, and its overexpression was correlated with the CSC markers CD44 and ALDH1 and the EMT marker Slug. The expression of RRM2 promotes the proliferation and migration of human OSCC cells and inhibits apoptosis.ConclusionRibonucleotide reductase M2 may be a novel target in the diagnosis, prognosis, and therapy of OSCC.
Percutaneous Vertebroplasty with Side‐Opening Cannula or Front‐Opening Cannula in the Treatment of Kummell Disease?
Authors: Wu Xi‐fa , Ping Yong , Zeng Xiang‐qin , Feng Yong , Wang Zhen , Li Tao , Wu Dong‐jin 
Published: July 2020

ObjectiveTo explore the effect of bone cement distribution, cement leakage, and clinical outcomes with side‐opening cannula for bone cement injection in percutaneous vertebroplasty (PVP) in treatment of Kummell disease.MethodsA prospective study of patients with Kummell disease undergoing PVP was conducted from April 2012 to September 2017. In total, 43 patients (11 males, 32 females) with Kummell disease who received bilateral PVP were included in the study. The patients were divided into front‐opening cannulas (FOC) group with front‐opening cannulas and side‐opening cannulas (SOC) group with side‐opening cannulas. All patients were followed up for 6 months. The patient general information such as gender, age, bone density, compression ratio, operative time, and location of fracture vertebrae were recorded. Visual analogue scale (VAS), Oswestry Disability Index (ODI), bone cement distribution, radiation exposure time, bone cement leakage rate and vertebral height, and kyphosis angle were measured and compared for two groups before surgery, 1 day and 6 months after surgery.ResultsA total of 43 patients were enrolled, including 11 males and 32 females, aged 61–84 years. The bone density (T value) was 2.5 ± 0.6 in FOC group and 2.4 ± 0.6 in SOC group (P > 0.05). The compression ratio and operative time were 36.1% ± 13.0%, 39.3 ± 7.9 min in FOC group and 35.2% ± 13.7%, 40.0 ± 10.7 min in SOC group (P > 0.05). There was no significance between FOC and SOC groups in the location of fracture vertebrae. All patients underwent at least 6 months of follow‐up. At 6 months postoperatively, the VAS and ODI were significantly higher in the FOC group (3.0 ± 0.8, 35.7% ± 2.1%) than in the SOC group (1.3 ± 0.4, 18.6% ± 2.4%) (P < 0.05). The cement leakage rate of the SOC group was 4.8%, which was lower than that of the FOC group (31.8%, P < 0.05), and the bone cement distribution ratio was higher than that of the FOC group (63.1% ± 7.9% vs 40.5% ± 8.6%, P < 0.05). At 6 months after operation, the height of the anterior and posterior vertebral bodies of the patients in the SOC group restored better than the FOC group (anterior SOC: FOC 5.1 ± 0.5 mm vs 4.5 ± 0.5 mm; posterior SOC: FOC 0.6 ± 0.1 mm vs 0.3 ± 0.1 mm, P < 0.05), and the kyphosis correction was more obvious than patients in FOC group (SOC: FOC 8.5° ± 1.4° vs 4.6° ± 0.8°, P < 0.05).ConclusionPercutaneous vertebroplasty with side‐opening cannula is safe and effective in avoiding bone cement leakage, improving bone cement distribution, and restoring vertebral height.
Differentiation between left bundle branch block (LBBB) preceded dilated cardiomyopathy and dilated cardiomyopathy preceded LBBB by cardiac magnetic resonance imaging
Authors: Wang Hui , He Yi , Du Xin , Yao Rui , Chang Sanshuai , Guo Fei , Bai Zhongle , Lv Qiang , Liu Xiaohui , Dong Jianzeng , Ma Changsheng 
Published: July 2020

AbstractBackgroundDilated cardiomyopathy (DCM) may be a result of or the cause of left bundle branch block (LBBB) in patients with DCM and LBBB. It is almost impossible from the history alone to know which came first in clinical work.MethodsPatients with LBBB and DCM who had cardiac magnetic resonance (CMR) examination were analyzed. Occurrence sequence of DCM and LBBB was determined by chart reviewing. Diastolic lateral/septal wall thickness ratio (DLSWTR) and lateral wall thickening (LWT) were compared between patients with different time sequences. Response to CRT was analyzed according to medical history and CMR manifestation.ResultsSixty‐three patients were divided into two groups by cluster analysis. DLSWTR and LWT were significantly higher in group 1 (preserved lateral wall thickness and function), compared to those in group 2 (reduced lateral wall thickness and function) (1.06 ± 0.13 vs. 0.8 ± 0.12, 34.57 ± 11.48% vs. 11.18 ± 5.56%, respectively, both P < .001). Occurrence sequence was clear in 14 patients and further analyzed. In group 1, seven patients were clearly having no evidence of DCM when LBBB was first diagnosed (defined as LBBB‐precede‐DCM) and in group 2, seven patients did not have LBBB when DCM was diagnosed (defined as DCM‐precede‐LBBB). Among 10 patients who received CRT therapy, all seven patients in group 1 responded well whereas none of three patients in group 2 responded well.ConclusionsOccurrence sequence of DCM and LBBB can be discriminated by CMR. Preserved lateral wall morphology and function in CMR suggested LBBB preceded to DCM. Such features may be predictors of good response to CRT.
The Compassionate Kitbag: A creative and integrative approach to compassion‐focused therapy
Authors: Lucre Katherine , Clapton Neil 
Published: July 2020

PurposeThis paper outlines the concept of the ‘Compassionate Kitbag’, a novel multi‐sensory‐based means of helping draw together the various elements of compassionate mind training and processes within compassion‐focused therapy (CFT), to help clients cultivate and facilitate their capacities for compassion. Building on the work of Lucre and Corten (2013,Psychology and Psychotherapy: Theory, Research and Practice, 86, 387), this is the first published work exploring this concept and the theoretical underpinnings, with a specific focus on how this can be used to support people with attachment and relational trauma.MethodsA narrative review of the literature on multi‐sensory stimulation in facilitating people's capacities for compassion was conducted, coupled with a review of the literature of the use of non‐human and transitional objects as explained by attachment theory and the broader scientific research underpinning the CFT model.ResultsClinical examples of how to use the Compassionate Kitbag to help stimulate compassionate therapeutic processes demonstrate the benefits of and how to begin utilizing this approach in compassion‐focused work with clients with complex needs.ConclusionsThe Compassionate Kitbag's potential therapeutic value lies in offering multifarious creative and tangible means of accessing compassion to a wide range of individuals whom are typically fearful of, blocked, and/or resistant to compassion. Further research into the wider application of the concept of the Compassionate Kitbag is needed.Practitioner pointsMany patients with ruptured and/or traumatized early attachment relationships can find more traditional talking therapies difficult to access.Compassion‐focused therapy (CFT) can offer an evolutionary‐based understanding of interpersonal difficulties which can be helpful for such patients.Creatively harnessing and utilizing multi‐sensory and non‐linguistic social signals in CFT is key to exercising the care‐giving and care‐receiving social mentalities that facilitate compassionate flow.There is considerable evidence to support the use of a multi‐sensory component to the therapeutic work to help patients cultivate and facilitate their capacities for compassion.The Compassionate Kitbag can be a way of supporting patients to create concrete representations of compassion in the context of the compassionate mind training component of the therapeutic work. Some of these objects can become transitional objects which can aid the therapeutic work.