bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge management system design method with joint application design (JAD) adoption
Authors: Sensuse Dana Indra , Rochman Hadiyan Nur , Al Hakim Shidiq , Winarni Winarni 
Published: February 2020

Purpose
This study proposes to adopt joint application design (JAD) in the requirement gathering process on developing a knowledge management system (KMS) using Fernandez methodology. It is proposed that Fernandez methodology produces only a list of KMS features and the requirement of the feature is still unclear. This study aims to produce KMS that meets the needs and expectations of users based on features of Fernandez's methodology.

Design/methodology/approach
This study was conducted using a combination methodology that combines Fernandez methodology to identify the feature needs of the organization and JAD to identify user requirements of KMS. The system prototype is evaluated by measuring user satisfaction using the Post Study System Usability Questionnaire.

Findings
The results of this study indicate that with the adoption of JAD it is possible to get the requirement in accordance with the expectations of the user. In addition, this study also shows that the level of user satisfaction with the prototype developed with the requirement is high at 84% of the maximum score.

Research limitations/implications
This study was used only in the education context, especially teaching assistant problems at the Faculty of Computer Science, University of Indonesia. For this reason, further research is needed for different contexts so that the implementation of this combination of methods can be generalized more broadly.

Practical implications
This paper provides practical implications for the development of KMS by identifying user requirements using JAD.

Originality/value
This paper provides a combination method to generate KMS that meets user requirements.
Role of BP230 autoantibodies in bullous pemphigoid
Authors: Shih Yen-chi , Wang Bo , Yuan Huijie , Zheng Jie , Pan Meng 
Published: February 2020

AbstractBullous pemphigoid (BP) is an autoimmune disease associated with subepidermal blistering due to autoantibodies directed against BP180 and BP230. BP180 is currently considered as the major pathogenic autoantigen. However, previous clinical findings suggested that anti‐BP230 autoantibodies alone can cause skin lesions in animal models and many BP patients. The characteristics of BP230 and the pathogenic roles of anti‐BP230 antibodies have been proposed. First, at the molecular level, BP230 mediates the attachment of keratin intermediate filaments to the hemidesmosomal plaque and interacts with other constituents of hemidesmosomes. Second, the presence of BP230 autoantibodies may correlate with specific clinical features of BP. The immunoglobulin (Ig)G autoantibodies from BP patients react mainly against the C‐terminus of BP230, while the IgE autoantibodies are still inconclusive. Third, in vivo, autoantibodies against BP230 involved in the disease may not only induce the inflammatory response but also impair the structural stability of hemidesmosomes. This article reviews recently published work about the role of BP230 and its antibodies, including IgG and IgE, aiming to find clues of its clinical association and lay the foundation for the research on the pathogenicity of antibodies against BP230.
LncRNA XLOC_003810 modulates thymic Th17/Treg balance in myasthenia gravis with thymoma
Authors: Niu Li , Jiang Jun , Yin Ying , Hu Bo 
Published: February 2020

AbstractImbalance of T helper 17 (Th17)/regulatory T (Treg) cells is involved in the pathogenesis of myasthenia gravis with thymoma (MG‐T). Long non‐coding RNAs (lncRNAs) are implicated in the regulation of Th17/Treg balance. This study was designed to explore the role of XLOC_003810, a novel lncRNA, in regulating the Th17/Treg balance in MG‐T. The thymic CD4+ T cells were isolated from control subjects and MG‐T patients. The Th17/Treg balance was evaluated by determining proportions of Th17 and Treg cells and expression of Th17‐ and Treg‐ associated molecules. Lentivirus‐mediated silencing and overexpression of XLOC_003810 in CD4+ T cells were performed. The results showed that XLOC_003810 expression was higher in MG‐T thymic CD4+ T cells than that in the control group. Furthermore, the ratio of Th17/Treg cells, proportion of Th17 cells and levels of Th17‐associated molecules were significantly increased, whereas the proportion of Treg cells and levels of Treg‐associated molecules were decreased in MG‐T thymic CD4+ T cells. Importantly, the Th17/Treg imbalance in MG‐T thymic CD4+ T cells was aggravated by XLOC_003810 overexpression, whereas it was attenuated by XLOC_003810 silencing. Collectively, XLOC_003810 modulates thymic Th17/Treg balance in MG‐T patients, providing the scientific basis for the clinical targeted therapy of MG‐T.
Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair
Authors: Marchetti Bianca , Tirolo Cataldo , L'Episcopo Francesca , Caniglia Salvatore , Testa Nunzio , Smith Jayden A. , Pluchino Stefano , Serapide Maria F. 
Published: February 2020

AbstractA common hallmark of age‐dependent neurodegenerative diseases is an impairment of adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β‐catenin (WβC) signalling is a vital pathway for dopaminergic (DAergic) neurogenesis and an essential signalling system during embryonic development and aging, the most critical risk factor for Parkinson's disease (PD). To date, there is no known cause or cure for PD. Here we focus on the potential to reawaken the impaired neurogenic niches to rejuvenate and repair the aged PD brain. Specifically, we highlight WβC‐signalling in the plasticity of the subventricular zone (SVZ), the largest germinal region in the mature brain innervated by nigrostriatal DAergic terminals, and the mesencephalic aqueduct‐periventricular region (Aq‐PVR) Wnt‐sensitive niche, which is in proximity to the SNpc and harbors neural stem progenitor cells (NSCs) with DAergic potential. The hallmark of the WβC pathway is the cytosolic accumulation of β‐catenin, which enters the nucleus and associates with T cell factor/lymphoid enhancer binding factor (TCF/LEF) transcription factors, leading to the transcription of Wnt target genes. Here, we underscore the dynamic interplay between DAergic innervation and astroglial‐derived factors regulating WβC‐dependent transcription of key genes orchestrating NSC proliferation, survival, migration and differentiation. Aging, inflammation and oxidative stress synergize with neurotoxin exposure in “turning off” the WβC neurogenic switch via down‐regulation of the nuclear factor erythroid‐2‐related factor 2/Wnt‐regulated signalosome, a key player in the maintenance of antioxidant self‐defense mechanisms and NSC homeostasis. Harnessing WβC‐signalling in the aged PD brain can thus restore neurogenesis, rejuvenate the microenvironment, and promote neurorescue and regeneration.
A Survey of Recent Evidence on Boards of Directors and CEO Incentives
Authors: Masulis Ronald W. 
Published: February 2020

AbstractThis article surveys the recent literature on boards of directors and the interplay between director incentives and CEO incentives. The primary focus is on how the incentives and other characteristics of directors, boards, and CEOs interact to affect firm performance. The article reviews the recent evidence documenting a causal relationship between board independence and measures of firm performance. It also discusses the major limitations of the current measure of director independence. Finally, the article highlights how board independence provides strong incentives for CEOs to create firm value and examines the recent evidence on what other director characteristics improve board effectiveness.
Bankers on the Board and CEO Turnover
Authors: Kang Min Jung , Kim Andy (Y. Han) , Chang Jeung‐Yoon 
Published: February 2020

AbstractThe governance literature finds that independent directors from lending banks (commercial bank directors or CBDs) bring both financial expertise and conflict of interest between shareholders and debt holders. We examine how the presence of CBDs affects the implicit incentive of CEO turnover. Using BoardEx and DealScan data, we hypothesize and find that CBDs make the CEO turnover more sensitive to both performance and risk. Post‐CEO turnover analysis reveals that firm performance improves and risk decreases in the presence of CBDs.
Process measure aimed at reducing time to haemorrhage control: outcomes associated with Code Crimson activation in exsanguinating truncal trauma
Authors: Tovmassian David , Hameed Ahmer M. , Ly Jessie , Pathmanathan Nimalan , Devadas Michael , Gomez David , Hsu Jeremy M. 
Published: February 2020

AbstractBackgroundMajor trauma activation is a process that mobilizes personnel and resources required to care for severely injured patients. Exsanguinating truncal trauma patients require an additional response beyond major trauma activation aimed at expediting haemorrhage control. To address this requirement, ‘Code Crimson’ (CC) activation was developed. Our aim was to examine the performance of CC activation as a process measure in the identification and management of patients with exsanguinating truncal trauma.MethodsRetrospective cohort study (2010–2015) of all adult patients who underwent operative intervention within 6 h of arrival for truncal trauma was performed. Patients were classified into: (i) major haemorrhage (assessment of blood consumption score ≥2, base deficit ≥5 and/or transfusion ≥5 U of red blood cells pre‐/intra‐operatively), or (ii) no major haemorrhage. We evaluated the proportion of patients with/without major haemorrhage in which a CC was activated as well as time to operating theatre across groups.ResultsA total of 210 patients were included with a median Injury Severity Score of 20 (interquartile range (IQR) 9–29) and overall mortality of 13%. Eighty‐nine patients were classified as major haemorrhage and 61 patients underwent CC activation. The majority of CC activations (92%) fulfilled major haemorrhage criteria (sensitivity 63%, specificity 96%). Time to theatre was lower in those with CC activation with median time of 23 min (IQR 15–39.5) versus non‐CC with median of 95 min (IQR 43–180, P < 0.001).ConclusionCC was primarily activated in patients with major haemorrhage and led to a decrease in time to theatre for patients with operative truncal trauma.
Feasibility and safety of two different surgical routes for the eradication of recto‐vaginal endometriosis with vaginal mucosa infiltration (Endo‐Vag‐r study)
Authors: Raimondo Diego , Turco Luigi C. , Cosentino Francesco , Mabrouk Mohamed , Mastronardi Manuela , Borghese Giulia , Giaquinto Ilaria , Vargiu Virginia , Fagotti Anna , Meriggiola Maria C. , Chiantera Vito , Scambia Giovanni , Seracchioli Renato 
Published: February 2020

AbstractIntroductionRecto‐vaginal endometriosis surgical management needing partial colpectomy is a surgically challenging condition and has been associated with a notable risk of major postoperative complications. In the present study we sought to compare feasibility and safety of total laparoscopic (TL) and vaginal‐assisted (VA) routes in women affected by symptomatic recto‐vaginal endometriosis with vaginal mucosa infiltration scheduled for minimally invasive surgery.Material and methodsMulti‐centric, retrospective cohort study on medical records of consecutive reproductive age women submitted to complete macroscopic eradication of symptomatic recto‐vaginal endometriosis with vaginal mucosa infiltration between March 2013 and November 2017. The two groups were compared in terms of preoperative data and surgical outcomes.Results84 women were included in the study (TL = 57 and VA = 27). The two groups were comparable in terms of preoperative, surgical and postoperative data. The major postoperative complications rate was 5.3% (3 of 57) in the TL group and 7.4% (2 of 27) in the VA group, without a significant difference. In the TL group we reported one case of bowel anastomosis dehiscence and two cases of pelvic abscess. In the VA group, one case of small bowel perforation after extensive adhesiolysis treated with ileal resection and one case of rectal sub‐occlusion after segmental resection and mechanical anastomosis were noticed.ConclusionsIn women affected by recto‐vaginal endometriosis with vaginal mucosal infiltration, perioperative outcomes do not seem to be influenced by the surgical route adopted.
Equitable access to ectogenesis for sexual and gender minorities
Authors: Kimberly Laura L. , Sutter Megan E. , Quinn Gwendolyn P. 
Published: February 2020

AbstractAs the technology for ectogenesis continues to advance, the ethical implications of such developments should be thoroughly and proactively explored. The possibility of full ectogenesis remains hypothetical at present, and myriad concerns regarding the safety and efficacy of the technology must be evaluated and addressed, while pressing moral considerations should be fully deliberated. However, it is conceivable that the technology may become sufficiently well established in the future and that eventually full ectogenesis might be deemed ethically acceptable as a reproductive alternative to gestation within a human womb under certain circumstances. If the safety and efficacy of full ectogenesis are established, if ethical dilemmas are sufficiently well addressed, and if the technology is offered as a reproductive option to cisgender heterosexual individuals or couples desiring to become parents, there is a moral obligation grounded in social justice to ensure that full ectogenesis be made available to individuals or couples identifying as members of sexual‐ or gender‐minority groups who likewise seek to pursue parenthood. We examine the history of access to current family‐building options, including assisted reproductive technology, surrogacy and adoption, for these populations and conclude that in the absence of robust empirical evidence suggesting an increased risk of harm to children of individuals and couples who identify as members of sexual‐ or gender‐minority groups, equitable access to ectogenesis as a pathway to parenthood for sexual and gender minorities must be assured as a matter of reproductive justice.
Planting Seeds for Social Dialogue: An Institutional Work Perspective
Authors: Gansemans Annelien , Louche Céline , D'Haese Marijke 
Published: February 2020

AbstractHow to get workplace social dialogue started at the bottom of Global Value Chains remains a difficult question. Drawing from institutional work literature, we investigate how local unions, supplier and buyer worked together to start the process of social dialogue in the anti‐union context of pineapple plantations in Costa Rica. The process unfolds along four phases each involving specific sets of institutional work. The study highlights the evolving brokerage role of the international buyer and the importance of balancing compliance and commitment approaches to build the foundation for workplace social dialogue.
The role of psychosocial factors and treatment need in dental service use and oral health among adults in Norway
Authors: Jönsson Birgitta , Holde Gro Eirin , Baker Sarah R. 
Published: February 2020

AbstractObjectivesThis study aimed to explore whether population characteristics were associated with the use of dental services, individual's personal oral health practices, dental caries and oral health‐related impacts using the revised Andersen's behavioural model as the theoretical framework.MethodsThis cross‐sectional study included participants from a Norwegian general population (N = 1840; 20‐79 years) included in the Tromstannen—Oral Health in Northern Norway (TOHNN) study. The variables included in the model were social structure (income, education, urbanization), sense of coherence (SOC), enabling resources (difficulties accessing the dentist, declined treatment, dental anxiety), treatment need, use of dental services, toothbrushing frequency, sugary soda drink consumption, decayed teeth and oral health‐related impacts (OHIP‐14). Structural equation modelling was used to test the direct and indirect effects within Andersen's behavioural model of access and health outcomes.ResultsAndersen's behavioural model fit the data well and explained a large part of the variance in use of dental services (58%), oral health‐related impacts (48%) and, to a lesser extent, decayed teeth (12%). More social structures and a stronger SOC was associated with more enabling resources, which in turn, was associated with more use of dental services. Social structures were not directly associated with use of dental services or decayed teeth but were predictive of oral health‐related impacts. A stronger SOC was associated with more frequent toothbrushing, less soda drink consumptions, fewer decayed teeth and less oral health‐related impacts. Self‐perceived need did not predict dental attendance but was associated with decayed teeth. A less frequent use of dental services, less frequent toothbrushing and more frequent sugary soda drink consumption were associated with more decayed teeth. Decayed teeth were not associated with oral health‐related impacts.ConclusionThe findings suggests that, in addition to focusing on reducing socioeconomic inequalities in relation to oral health in the Norwegian population, it is also important to consider how people perceive their own resources (eg financial, psychological, social) as well as their access to dental care in order to support regular dental attendance and potentially, in turn, enhance oral health.
Evaluation of green and sustainable building project based on extension matter‐element theory in smart city application
Authors: Li Ming , Xu Kang , Huang Sheng 
Published: February 2020

AbstractThe postoccupancy performance and operation management level of green building largely determines the overall sustainability level of green buildings. It is necessary to evaluate the degree of success of green buildings in the operation stage to ensure the implementation effect of the whole life cycle. However, the current green building evaluation system is incomplete, and the research on the degree of success evaluation of green buildings is very lacking. It is necessary to establish a scientific and effective evaluation index system to evaluate the degree of success of green buildings. This article applies the extension matter‐element theory and entropy method to evaluate the degree of success of green building projects, taking a green building project in Nanchang as an example, and seven experts were invited to score and evaluate the project's degree of success by calculating the relevance degree of each evaluation index. The results show that this green building's degree of success emerged as at level II, that is, the “generally successful” level, and each first‐level indicator, respectively, lay at level III, level II, level II, and level II. The case study proves that the evaluation method of green building determined in this article is scientific and reliable.
Use of a predictive colour model for managing the colour appearance of two‐colour woven fabrics
Authors: Dimitrovski Krste , Grmek Andreja , Gabrijelčič Tomc Helena 
Published: February 2020

AbstractThe aim of this study was to implement a two‐dimensional colour appearance model for prediction of the colour values of weft threads when the optical mixing of a two‐colour woven structure had to match the colour appearance of a single‐colour reference woven fabric. Five single‐colour woven fabrics were woven from five threads of similar hue. One of the samples was chosen as a reference, for which the colour appearance was the goal to be achieved in the two‐colour woven fabrics prepared with the other available warp threads and newly dyed weft threads. The colour values of dyed weft threads were predicted by a two‐dimensional colour appearance model. With dyed weft threads, managing the colour appearance of the two‐colour woven fabric was enabled to achieve the colour values of the reference. In the results, colour deviations between the predicted and measured colour values of weft threads revealed some limitations to the colour appearance model and performance of the dyeing process. After the production of the two‐colour woven fabric, the colour appearance matched the appearance of the reference, resulting in deviations of ΔECMC(2:1) = 1.2‐7.8. Moreover, the differences between theoretically predicted and measured colour values of the two‐colour woven fabric were evaluated as small, ranging from ΔECMC(2:1) = 1.5‐1.9. The results demonstrated the efficiency of implementing the colour appearance model and the dyeing process of weft threads as an approach to achieve the defined colour appearance of two‐colour woven fabrics, which with small colour deviations matches the colour of a single‐colour reference.
Scleromyxedema histopathologically mimicking hypercellular fibrous papules (angiofibomas): Case report of an unusual histopathological presentation
Authors: Kazlouskaya Viktoryia , Khan Neelam , Heilman Edward 
Published: February 2020

AbstractScleromyxedema (SMX) is an inflammatory condition of unknown etiology strongly associated with monoclonal gammopathy. Classical histopathology of SMX is characterized with the triad of diffuse mucin deposits, increased amount of collagen, and presence of stellate fibroblasts. Herein, we report an unusual histopathological variant of SMX in a 41‐year‐old female with lesions of the nose histopathologically mimicking cellular angiofibromas. The dome‐shaped papules were characterized by increased collagen bundles and fascicles of spindle cells. Widened vessels were seen at the periphery of the proliferation. Cells expressed CD68. Factor XIIIa was expressed only by dendritic cells. The mucin was highlighted with colloidal iron. In sum, we draw attention to this unusual variant of SMX, which should be suspected in a setting of multiple “angiofibromas/fibrous papules” on the face with presence of mucin.
Aortic valve cusp aneurysm as a result of blood culture‐negative infective endocarditis, interesting echocardiographic and surgical images
Authors: Hajsadeghi Shokoufeh , Pazoki Mahboubeh , Pakbaz Marziyeh , Zeraatian Sam , Zaeim Mohammad Amin 
Published: February 2020

AbstractCompared to mitral valve aneurysms, aortic valve (AV) aneurysm is a more rare and serious complication of infective endocarditis (IE). Early surgical intervention and valve replacement are required in order to prevent further complications such as embolization and rupture of aneurysm. We described a case of severe aortic regurgitation (AR) as a result of an aortic valve aneurysm in a patient with history of end‐stage renal disease (ESRD) in whom the hemodialysis catheter had not been changed for a year.