bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imbalance in the duality of criminal activity and its proving
Authors: Afanasyev A. Yu. 
Published: December 2024

Objective: to verify and confirm (or refute) the hypothesis about the mismatch between the means of proof and the means of criminal activity in terms of strength and diversity, which causes imbalance in the dualism of criminal activity and its proving. Methods: in solving the research problem, we used, first of all, dualistic and hypothetical-deductive methods, as well as methods of functional systems, comparison and other general scientific methods. Results: criminal activity and its proving show the dualism of two complex functional systems, which are opposite, not reducible to each other, equal, but not equipollent. The lack of equipollency is manifested in the inconsistency of the means of proof with the means of criminal activity in terms of strength and diversity. On the one hand, the available means of proof are outdated and limited; on the other hand, they are used ineffectively when forming evidentiary systems of different levels. This leads to imbalance in the dualistic system. This is confirmed by systemic problems of reality – critically low disclosure rate, violation of the rights and freedoms of participants in criminal proceedings, low level of compensation for damages from crimes, protracted procedures of multi-volume criminal cases, etc. Scientific novelty: for the first time, the activity of proving is presented as a complex functional system, which together with criminal activity forms a dualism. In this dualistic system, an imbalance is found, consisting in the non-equipollent relationship between the two functional systems, where the means of proving are inferior to the means of criminal activity both in strength and in diversity. In this regard, the article attempts to reveal the mechanism of proving in order to determine how the two sides in the dualistic system can be balanced. Practical significance: the provisions laid down in the study can in the future act as a methodological basis for improving the means of proving and increasing the effectiveness of forming evidentiary systems of different levels.
Dual panic theory: new Insight into moral panics
Authors: Adams O. L. , Behl J. 
Published: December 2024

Objective: to comprehensively analyze the moral panic concept, developed in the works by S. Cohen, and to elaborate, on its basis, a new concept – the dual panic theory. Methods: dialectical approach to cognition of social phenomena, allowing to analyze them in historical development and functioning in the context of the totality of objective and subjective factors, which predetermined the following research methods: formal-logical, sociological. Results: Moral panics have been broadly discussed in the public discourse since S. Cohen’s (1972) seminal text on the topic. Despite copious research, we believe that the theory is in need of expansion due to the increased complexity of societal interactions. Through the lens of an increasingly polarizing American culture, we believe the original concept of moralpanics is overly simplified and no longer encompasses the intricacies of American society. Using the story of the McCloskey family’s 2020 interactions with Black Lives Matter protestors and Goode and Ben-Yehuda’s (1994) definitional criteria, we propose a new, expanded theory of moral panics – Dual Panic Theory. Scientific novelty: based on the analysis of the existing approaches to the moral panic concept, the paper offers and elaborates a new concept – the dual panic theory. It suggests that an event can happen that causes a competing panic by two opposing sides of an issue. Different from a culture war, dual panics are genuine panics about an action rather than a reaction to oppositional outrage from a competing interest group. Goode and Ben-Yehuda argue that researching moral panic cannot be complete without an examination of all societal levels, from elites to grassroots, and the full spectrum from ideology and morality at one end to crass status and material interests at the other. As society has evolved, so too must the theoretical explanations of societal reactions, moral panic or otherwise. Practical significance: the main provisions and conclusions of the article can be used in scientific, pedagogical and law enforcement activities when considering the issues related to the moral panic concept.
Long-term clinical outcomes with an average of 6 years follow-up in dRTA patients treated with ADV7103 an oral twice-daily fixed and prolonged-release combination of potassium bicarbonate and potassium citrate (Sibnayal®).
Authors: Bertholet-Thomas Aurelia , de-mul Aurelie , Roussey-Kesler Gwenaëlle , Podracka Ludmila , Novo Robert , Nobili Francois , Knebelmann Bertrand , Harambat Jerome , Golubovic Emilija , Boyer Olivia , Maio Massimo Di , Caillez Mathilde , Baudouin Veronique , Chidler Laure , Leblanc Veronique , Bacchetta Justine 
Published: December 2024

Abstract

Background:
Distal renal tubular acidosis (dRTA) is a rare disease characterized by hyperchloremic metabolic acidosis affecting growth, bone and kidney health.
Methods:
The aim of B22CS study was to evaluate long-term safety and efficacy of ADV7103, a prolonged-release alkalizing formulation with twice daily dosing, in children and adults with dRTA.
Results:
A total of 30 patients with inherited dRTA (mean age:10.6±6.0 years) already treated with ADV7103 entered this long-term study (average of 6 years).
ADV7103 was well tolerated over the study duration. ADV7103 allowed a sustained control of metabolic acidosis as plasma bicarbonate level was 22.0±3.2 mmol/L at baseline versus 22.6±2.5 mmol/L at the End of Follow-up (EoF), p=NS.
From baseline to EoF, mean Z-score height significantly increased (-0.6±1.0 to -0.3±1.0, p=0.03), without significant change in weight and body mass index. Kidney function remained stable from baseline to EoF: estimated glomerular filtration rate =105±17 and 104±20 mL/min/1.73m2, respectively, p=NS.
Urinary ratios: Calcium/Creatinine (UCa/UCr), Citrate/Creatinine (UCi/UCr), Calcium/Citrate (UCa/UCi) were not significantly different between baseline and EoF (p=NS). Both percentages of patients with nephrocalcinosis and with nephrolithiasis remained stable between baseline and EoF (p=NS).
Mean lumbar bone mineral density Z-score significantly increased from baseline (-1.1±1.0) to EoF (-0.8±1.0), p=0.005, with significant improvement between baseline and EoF in pre- and post-pubertal patients (p=0.035 and p<0.001, respectively), whilst it was maintained in pubertal patients (p=NS).
Conclusion.
Long-term data support the good safety and efficacy profile of ADV7103 in the treatment of dRTA with adequate control of metabolic acidosis, stable kidney function and significant positive long-term clinical outcomes.
Influence of a preload on the fatigue behaviour of S355 and S700 cruciform joints
Authors: Guilmois Lauriane , Huther Isabel , Jubin Laurent , Lefebvre Fabien , Leray Vincent 
Published: December 2024

Abstract

Preload application techniques are often used to verify the structural integrity of mechanical systems. Generally, these procedures are performed after the fabrication but before the commissioning of such equipment, without any assessment of the preload impact on fatigue behaviour. These approaches are imposed by standards such as ASTM or DNV that define applicable preload conditions but neither technical justification nor quantification of the impacts are usually given. The aim of this study is to evaluate the effect of a preload for various levels of plastic strains on structural steel S355 or high-strength steel S700 cruciform joints. Fatigue tests were performed in tension (R = 0.1) without preload as reference and after two different levels of preload corresponding to, on one hand a local stress close to the weld toe equal to 1.25 times the yield stress and on the other hand a local stress equal to 1.56 times the yield stress. The fatigue results show an increase of the fatigue strength, depending on the configuration (load-bearing weld beads or load-bearing weld beads), between two and seven FAT classes for the highest level of preload.
Comprehensive Analysis of PIK3CA Mutations in Advanced Colorectal Cancer Using Circulating Tumor DNA Profiling
Authors: Milsap Allante , Tsai Jill , Jafry Baqir , Kim Alex , Kazmi Syed , Verma Nilesh 
Published: December 2024

Abstract

Mutations in PIK3CA are prevalent in advanced colorectal cancer (CRC) and are associated with advanced-stage disease and poor prognosis. However, the prognostic value of these mutations remains unclear. In order to better understand their role in CRC progression, we evaluated the genomic landscape of PIK3CA mutations (PIK3CAm) in advanced CRC using plasma-based ctDNA from ~17,000 samples (Guardant360 database). Mutation co-occurrence, MSI-H status, TMB scores, and exon-specific mutation frequencies were analyzed. Our study shows that the frequency of PIK3CAm (19.2%) and distribution of exons 9 and 20 are similar to those found previously in the literature. Our results demonstrate PIK3CAm having a low frequency of MSI-H co-occurrence, higher TMB scores, and increased co-occurring alterations with notable increased in APC, BRAF, EGFR, ERBB2and KRAS, which may suggest higher genomic instability. Our findings underscore the clinical significance of PIK3CAm in CRC and supports the development of tailored therapeutic strategies targeting this mutation.
Acceleration of the the MVS Workflow using Graphics Processors
Authors: Díaz-Cano Roberto , Folch Francesc , Quintana-Ortí Enrique S. , Alonso-Jordá Pedro 
Published: December 2024

Abstract

Computer Vision (CV) leverages artificial intelligence to analyse digital images, offering insights for a wide range of different applications. While CV software often relies on open source libraries such as OpenCV, it is probably more common for this software to use custom codes. Creating particular solutions stems from the very nature of the specific CV problems being addressed but, despite these particularities, there are common links at the core that are either not addressed by generic CV libraries or require significant customisation for specific applications. Understanding the nature of real problems faced by a digital image analysis use case can contribute as much as solving a generic CV problem, and this is the aim of this paper.
This article addresses the problem of migrating to CUDA a part of MVS, a complex CV workflow utilised in a real-world, industrial use case. The primary challenge lies in minimising the overhead due to data transfers between the host and GPU (graphics processing unit), or even within the device’s memory itself. While the speed-up achieved may not rival that of other applications more suitable to GPU architecture (in particular, massively data parallel applications), the algorithms and data distribution proposed in this study effectively offload a substantial portion of the workflow to the GPU in the context of low (integer) arithmetic intensity and real-time constraints. This frees the CPU to handle other workflow components and increases the capability to incorporate more cameras, significantly boosting productivity and economic performance.
Rational inattention as a transdiagnostic marker of mental disorders
Authors: Houser Troy 
Published: December 2024

Abstract

People tend to choose immediate payouts over larger payouts to be made in the future. This is called temporal discounting. Substantial research has indicated that steeper temporal discounting is associated with reduced self-control and various mental disorders, making it a plausible transdiagnostic marker of mental disorders. Recently, a novel theoretical framework and accompanying computational model has called into question the interpretation of temporal discounting as lack of self-control. Instead, this new framework suggests that temporal discounting is a function of uncertainty in cognitive representations of the future. This is an important distinction with regard to temporal discounting’s transdiagnostic standing because it means that reduced allocation of cognitive resources to representing future reward (rational inattention) is the transdiagnostic marker of mental disorders and not solely a lack of self-control. To test this possibility, here we compare the model of rational inattention to the classical hyperbolic model of intertemporal choice. We additionally evaluate the ability of rational inattention to predict a suite of psychopathological symptoms. We find that rational inattention does capture intertemporal choice better than the traditional model and that it correlates with dimensions of psychopathology. This work can inform cognitive-behavioral interventions of various mental disorders, as well as guide future research on intertemporal decision-making.
Psychological Responses to Acute Exercise in Patients With Stress-induced Exhaustion Disorder: a Cross-over Randomized Trial
Authors: Kling Jenny , Asplund Robert Persson , Ekblom Örjan , Blom Victoria 
Published: December 2024

Abstract

Background
Understanding acute psychological responses to physical exercise is important since they likely influence the initiation and maintenance of this behavior. Given its effectiveness in reducing symptoms in various psychological disorders, physical exercise should be further explored in Exhaustion Disorder (ED; ICD-10-SE: F43.8A), a condition characterized by persistent exhaustion following long-term psychosocial stress. Currently, no studies are available on the psychological effects of acute exercise in ED patients.
Aims
This study aims to (1) investigate the psychological responses to acute exercise in ED patients compared to healthy controls and (2) determine if these responses differ between low and moderate exercise intensities.
Methods
We conducted a two-armed cross-over trial in two groups: ED patients (n = 30) and healthy controls (n = 30). On two separate occasions, participants completed a 22-minute exercise at low or moderate intensity on a cycle ergometer, in randomized order. The main outcome was perceived fatigue, and secondary outcomes were feelings of energy, anxiety, stress, perceived exertion, and perceived psychological discomfort, all measured before, during, and up to 24 hours after exercise. Effects of the exercise conditions were assessed with repeated measures analysis of variance.
Results
ED patients reported higher exertion and psychological discomfort before and during exercise, higher fatigue, anxiety, and stress but lower energy throughout the trial compared to the controls. ED patients experienced more reduced fatigue and stress after both intensities (p < 0.05), and a more elevated energy after moderate-intensity exercise compared to controls (p < 0.05). No interactions between groups were found for anxiety over time. No differences were observed between pre-exercise and 6 hours or 24 hours post-exercise in any variables. The only intensity effect (p < 0.05) in the ED patients was a more pronounced energy decline 30 minutes after moderate-intensity exercise.
Conclusions
A 22-minute exercise was perceived as more strenuous by patients with exhaustion disorder and generated greater improvements in feelings of fatigue, energy, and stress compared to healthy individuals, without delayed negative changes. These findings can inform intervention design and guide clinical practice.
Trial registration
The study was retrospectively registered on 05/30/2024 at Clinical Trials.gov, with trial registration number 2022-04943-01.
Effect of antihypertensive drugs on mortality and readmission in new-onset hypertension patients with acute exacerbations of chronic obstructive pulmonary disease in hospitals: A multicenter retrospective observational cohort study
Authors: Wang Yi , Chen Jia-Hao , Lin Jian-Cheng , Sun Jia-Yan , Di Yin , Guo Qiang 
Published: December 2024

Abstract

Background: COPD is the third leading cause of death worldwide, and is often complicated by exacerbations, infections, and cardiovascular complications, which frequently result in poor patient prognosis.
METHODS: Patients were categorized into a good prognosis group and a poor prognosis group on the basis of their 28-day survival events and readmission status. Propensity score matching (PSM) was used to eliminate the interference of confounding factors between groups on clinical outcomes. Univariate and multivariate regression analyses were performed on both matched and unmatched cohorts to assess the impact of various factors on mortality.
RESULTS: Multivariate analysis of the unmatched cohort revealed that the use of DCCBs (HR = 2.006, 95% CI 1.202-3.350, P = 0.008) and elevated C-reactive protein levels (HR = 1.004, 95% CI 1.001-1.008, P = 0.013) were independent risk factors for hospital readmission within one year. Conversely, β-blocker use (HR = 0.230, 95% CI 0.068-0.772, P = 0.017) was a protective factor. In the PSM cohort, univariate analysis revealed that DCCB use (HR = 1.760, 95% CI 1.042-2.972, P = 0.034), FEV1% pred ≤ 40.10% (HR = 2.347, 95% CI 1.278-4.310, P = 0.006), and CRP ≥ 11.59 mg/L (HR = 2.084, 95% CI 1.242-3.497, P = 0.005) were independent risk factors for readmission within one year, wheras β-blocker use (HR = 0.227, 95% CI 0.067-0.765, P = 0.017) was a protective factor. Patients not treated with DCCBs had better prognoses than did those treated with DCCBs. Beta-blocker users had a lower readmission rate, although beta-blockers did not significantly affect the 28-day survival rate.
CONCLUSIONS: The use of DCCBs, FEV1% pred ≤ 40.10%, and elevated CRP levels were independent risk factors for readmission within one year for moderate to severe AECOPD patients with new-onset hypertension. Conversely, β-blockers were protective against readmission in this patient group.
Risk of recurrence in surgically treated Middle-ear Cholesteatomas - A retrospective cohort study
Authors: Jacobsen Line Voss , Rasmussen Simon Mylius , Schousboe Lars Peter 
Published: December 2024

Abstract

Cholesteatomas are benign tumors in the temporal bone which can damage surrounding structures through inflammatory, osteolytic activity. Surgery is the only curative treatment, but there is potential for recurrence. This study aimed to investigate the risk of recurrence after surgically treated middle-ear cholesteatoma in order to evaluate the need for post-operative follow-up. Medical records of patients with the diagnosis middle-ear cholesteatoma were thoroughly and systematically reviewed to gather information about surgery until recurrence, death or end of follow-up. Data was analysed by performing a time-to-event analysis and descriptive statistics. We found that among 267 included patients, 20% had recurrent disease. Stratified by age, 18% of the adults and 36% of the children experienced recurrence, with 78% of adults and 39% of children experiencing recurrence beyond the recommended follow-up time of 2 and 5 years, respectively. Children had a significantly higher risk of recurrence compared to adults. The majority of patients with recurrence were treated with mastoidectomy. In conclusion, the recurrence rate after cholesteatoma surgery is 20%, in accordance with previous findings. A prolonged, age-stratified and more systematic follow-up is suggested considering the high risk of recurrence in children compared to adults.
Assessing the Quality of Mortality Data in Zunyi, China: A Comparative Study of Garbage Coding Before and After Intervention
Authors: Zhang Bo , tang haibo , Wei Deqin , Long Tao , Huang Yuanmou , wang Jian , Zhang Yi , Shi Xiuquan , Tian Dalin , Guo Hailei , Cao Jiayan 
Published: December 2024

Abstract

BACKGROUND: Accurate mortality data are crucial for understanding mortality patterns, informing public health strategies, and evaluating national health programs. In 2022 and 2023, the Centers for Disease Control and Prevention in Zunyi, China, provided specialized training to staff responsible for cause-of-death surveillance.
METHODS: This study evaluated the quality of cause-of-death data reported by healthcare organizations in Zunyi city before and after the intervention, with a focus on the classification and extent of garbage codes. By comparing the distributions of various causes of death and their changes over the two years, we analyzed the differences and distribution patterns of garbage codes. The study participants were grouped by age and sex.
RESULTS: The cause-of-death data from Zunyi demonstrated good completeness over the two-year period. The proportion of definite causes of death increased significantly from 87.5% to 94.8%, whereas the proportion of unusable causes decreased notably, from 7.32% to 2.87%. Similarly, the proportion of garbage codes relative to total deaths decreased from 12.60% to 5.20%, with significant reductions in categories 3 and 5. The major garbage codes in both years exhibited a positively skewed distribution, which was primarily associated with aging and cardiovascular diseases. The proportion of garbage codes decreased across both the male and the female groups over the age of 65.
CONCLUSION: This study offers a cost-effective approach to improve the quality of cause-of-death data through a junk code-based assessment method. By implementing these measures, the accuracy and utility of cause-of-death data can be greatly enhanced.
Transcatheter arterial infusion chemotherapy combined with lipiodol chemoembolization for advanced gastric fundus and cardia cancer with obstruction
Authors: Zhou Gang , Ma Yaozhen , Ma Yishu , Ding Xiaolong , Liu Tao , He Wei , Jin Shuiling , Li Chunxia , Yin Meipan , Wu Gang 
Published: December 2024

Abstract

Purpose
Gastric fundus and cardia cancer are increasingly common, diagnosed at a late stage, often with severe obstruction, and have a poor prognosis. Transcatheter arterial lipiodol chemoembolization (TACE) is rarely used for gastric cancer. This single-center retrospective study aimed to analyze the efficacy and safety of transcatheter arterial infusion chemotherapy (TAI) combined with TACE in advanced gastric fundus and cardia cancer with obstruction and compare it to bland embolization (BE).
Materials and Methods
The clinical efficacy of TAI-TACE was evaluated through technical and clinical success rates, obstruction relief, tumor response, overall survival (OS), and postoperative adverse events. TAI-TACE and TAI-BE efficacies were compared.
Results
The study included 53 patients (age 70.0 ± 11.1 years, 38 males). Thirty-two patients underwent TAI-TACE, and 21 underwent TAI-BE. The cohort’s technical success rate was 100%. The pre- and post-intervention median Stooler grades were 4 and 2 in the TAI-TACE group and 3 and 3 in the TAI-BE group, respectively. Compared to the TAI-BE group, the TAI-TACE group had a higher clinical success rate (78.1%, 25/32 vs. 42.9%, 9/21; P = 0.009), a better objective response rate (53.1% vs. 38.1%; P = 0.016), and a longer median OS (13.0; 95% confidence interval (CI), 3.2–22.8 vs. 10.0; 95% CI, 8.5–11.5; P = 0.039) months. All adverse events were grade 1.
Conclusion
The TAI-TACE interventional therapy scheme was safe and effective, achieving rapid tumor shrinkage, obstructive symptom alleviation, improved quality of life, and a significantly better overall effect than TAI-BE.