bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of reduction hepatectomy and postoperative multidisciplinary therapy for 30 unresectable advanced hepatocellular carcinomas
Authors: Asahi Yoh , Kamiyama Toshiya , Kakisaka Tatsuhiko , Orimo Tatsuya , Shimada Shingo , Nagatsu Akihisa , Sakamoto Yuzuru , Kamachi Hirofumi , Taketomi Akinobu 
Published: December 2020

Abstract
Background

The role of volume reduction hepatectomy in the treatment of unresectable advanced hepatocellular carcinoma remains unclear. This study aimed to examine the outcomes of combination treatment with reduction hepatectomy and multidisciplinary postoperative treatment for unresectable advanced hepatocellular carcinoma.
Methods

Thirty cases of unresectable advanced hepatocellular carcinoma, in which reduction hepatectomy was performed between 2000 and 2018 at the Department of Gastroenterological Surgery I, were divided into POCR(+) and POCR(-) groups, depending on whether postoperative complete remission (POCR) of the evaluable lesions was achieved through postoperative treatment. The cases in the POCR(-) group were subdivided into POCR(-)TKI(+) and POCR(-)TKI(-) groups, depending on whether tyrosine kinase inhibitors (TKIs) were administered postoperatively.
Results

The 5-year overall survival rate and mean survival time (MST) after reduction hepatectomy were 15.7% and 28.40 months, respectively, for all cases; 37.5% and 56.55 months, respectively, in the POCR(+) group; and 6.3% and 14.84 months, respectively, in the POCR(-) group (p = 0.0041). Tumor size, vascular invasion, and the number of tumors in the remnant liver after the reduction hepatectomy were also found to be related to survival outcomes. The number of tumors in the remnant liver was the only factor that differed significantly between the POCR(+) group and POCR(-) group, and POCR was achieved significantly more frequently when ≤ 3 tumors remained in the remnant liver (p = 0.0025). The MST was 33.52 months in the POCR(-)TKI(+) group, which was superior to the MST of 10.74 months seen in the POCR(-)TKI(-) group (p = 0.0473).
Conclusions

Reduction hepatectomy and multidisciplinary postoperative treatment for unresectable advanced hepatocellular carcinoma resulted in a 5-year overall survival rate of 15.70% and an MST of 28.40 months. The treatment strategy was effective when POCR was achieved via multidisciplinary postoperative therapy. To achieve POCR, reduction hepatectomy should aim to ensure that ≤ 3 tumors remain in the remnant liver. Even in cases in which POCR is not achieved, combined treatment with reduction hepatectomy and multidisciplinary therapy can improve survival outcomes when TKIs are administered.
Identification of molecular markers associated with the progression and prognosis of lung adenocarcinoma:a bioinformatic study
Authors: Du Kexin , Wang Xioahan 
Published: December 2020

Abstract
Objective: For the identification of genes of prognostic significance related to tumor microenvironment (TME) in lung adenocarcinoma.Methods and Materials: Transcriptome data and clinical data of lung adenocarcinoma originated from the Cancer Genome Atlas (TCGA) database. Immune scores and stromal scores were calculated by “Estimation of Stromal and Immune cells in Malignant Tumors using Expression data” algorithm. Based on these calculated scores, the samples were classified as high and low score groups. The average score of respective gene in different groups was calculated. A heat map was created to screen out genes exhibiting differential expressions. The interaction of up-regulated differentially expressed genes (DEGs) and down-regulated DEGs was harvested from a Venn diagram and then covered in the overlapping genes. The core genes influencing prognosis of lung adenocarcinoma were screened out by function enrichment analysis, protein-protein interaction network analysis and Kaplan-Meier (K-M) method on the overlapping genes.Results: A total of 515 samples of lung adenocarcinoma were harvested from TCGA database. As revealed from the results, a high immune score was related to a high survival rate, while the matrix did not show significant relationships to survival rate. A total of 775 DEGs and 367 overlapping genes were harvested. The functions of these overlapping genes were tightly correlated with DEGs and immune response and were noticeably improved in cytokine-cytokine receptor interaction and chemokine signaling pathway. Eight genes, namely, CCR5, CCR2, CCL14, GNRH2, PKHD1L1, MS4A1, FCER2 and FDCSP, were correlated with prognosis of lung adenocarcinoma.Conclusion: The genes and pathways affecting prognosis of lung adenocarcinoma were screened out, which offer ideas for subsequent study on lung adenocarcinoma.
Alterations of the Gut Microbiome and Metabolome in Patients with Proliferative Diabetic Retinopathy
Authors: Yao Ke , Ye Panpan , Zhang Xueyou , Xu Yufeng , Xu Jia , Song Xiaoxiao 
Published: December 2020

Abstract
Background: Diabetic retinopathy (DR) has been reported to associate with gut microbiota alterations in murine models and thus “gut-retina-axis” has been proposed. However, the role of gut microbiome and the associated metabolism in DR patients still need to be elucidated. Results: Fecal samples from 45 patients with proliferative DR (PDR) and 90 matched diabetic patients (1:2 according to age, sex and duration of diabetes) without DR (NDR) were subjected to 16S rRNA gene sequencing and untargeted metabolomics. Significantly lower bacterial diversity was observed in PDR group than that in NDR group. Differential gut bacterial composition was found, with significant depletion of 22 families (e.g., Coriobacteriaceae, Veillonellaceae and Streptococcaceae) and enrichment of 2 families (Burkholderiaceae and Burkholderiales_unclassified) in PDR group as compared to NDR group. There were significantly different fecal metabolic features, which were enriched in metabolic pathways such as arachidonic acid and microbial metabolism, between the two groups. Among 36 co-abundance metabolite clusters, 11 were positively/negatively contributed to PDR using logistic regression analysis. Fifteen gut microbial families were significantly correlated with the 11 metabolite clusters. Furthermore, a fecal metabolites-based classifier was constructed to distinguish PDR patients from NDR patients accurately.Conclusions: PDR is associated with reduced diversity and altered composition of gut microbiota and specific microbe-metabolite interplay. Our findings help to better understand the disease pathogenesis and provide novel diagnostic biomarkers and therapeutic targets for PDR.
Towards a Smart GIS Public Health Record System for the Capital Governorate, State of Kuwait
Authors: Aziz Mohamed Alkhuzamy , Al-Helal Huda Ibrahim 
Published: December 2020

Abstract
Health care services are considered the sign of a contemporary civilized society, reflecting its level of modernity. A study of the developmental stages and location variables of health care services can facilitate understanding location characteristics for a progressive perspective to achieve optimal standards of health care service. This study focuses on the 17 public health centers located within the districts of the Capital Governorate, State of Kuwait. The scientific methodology that is used in this study is based on a spatial and geo-statistical analysis of public health centers. The results of this applied analysis highlight the inadequacies of the current management system running public health facilities in the State of Kuwait. The study seeks to create a new system based on GIS technology dubbed “Public Health Record Information System”. The proposed system would not only rectify patient health record errors, but also improve the overall health management process.
A Label-Free Proteomic Strategy to Investigate the Intramuscular fat Proteomic Differences Between Biceps Femoris and Longissimus Dorsi in Inner Mongolian Cashmere Goats
Authors: Xie Yuchun , Liu Zhihong , Nai Rile , Guo Juntao , Su Xin , Zhao Cun , Zhang Chongyan , Qin Qing , Dai Dongliang , Wang Zhixin , Zhao Yanhong , Su Rui , Wang Zhiying , Wang Ruijun , Zhang Yanjun , Li Jinquan , Li Haijun 
Published: December 2020

Abstract
Background: As a major raw-cashmere-producing province in China. Nearly 700,000 Aerbasi cashmere goats are fed per year, and the corresponding meat production is nearly 10,000 tons. However, there are no reports on the meat of this goat. To better understand the molecular variations underlying intramuscular fat (IMF) anabolism and catabolism in Inner Mongolian cashmere goats, the proteomic differences between the biceps femoris (BF) and longissimus dorsi (LD) were investigated by a label-free strategy. Then, the identified proteins were verified as being involved in IMF anabolism and catabolism by Western blot analysis.Results: The IMF content was significantly higher in the BF than in the LD, suggesting that IMF accumulated more in the BF or was metabolized more in the LD. We performed proteomic analysis of IMF anabolism and catabolism at the proteomic level, and 1209 proteins were identified in the BF (high-IMF) and LD (low-IMF) groups. Among them, 110 were differentially expressed proteins (DEPs), 81 of which were upregulated in the high-IMF group, while 29 were upregulated in the low-IMF group. Gene ontology (GO) classification showed that the 110 DEPs were functionally classified into 100 annotation clusters. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the 110 DEPs covered 34 KEGG pathways. Three pathways were related to IMF metabolism and deposition—fatty acid metabolism, fatty acid degradation and fatty acid elongation—and included 7 proteins.Conclusion: GO and KEGG analyses showed that differentially expressed HADHA, HADHB, ACSL1, ACADS, ACAT1 and ACAA2 in the mitochondria act via fatty acid metabolism, fatty acid degradation and fatty acid elongation to influence the metabolism and synthesis of long-, short- and medium-chain fatty acids and modulate IMF anabolism and catabolism. Protein-protein interaction (PPI) network analysis showed that IMF accumulation in different muscle tissues of Inner Mongolian cashmere goats was affected not only by 5 key enzymes and proteins involved in fatty acid synthesis and metabolism but also by five DEPs (SUCLG1, SUCLG2, CS, DLST, and ACO2) in the TCA cycle. Our results provide new insights into IMF deposition in goats and improve our understanding of the molecular mechanisms underlying IMF anabolism and catabolism.
Co-designing Research Methods Lesson Plans in the Interactive Research Methods Lab
Authors: Jorrín Abellán Ivan M. , Vasquez Anete , Gaines Rachel E. 
Published: December 2020

In this article we present a series of co-design sessions conducted throughout the 2019-2020 academic year, of which the aim was to plan and implement lessons on research methods for undergraduate and graduate students in the Interactive Research Methods Lab (IRML). The IRML is a brand new resource in the Bagwell College of Education (Kennesaw State University) that provides students with personalized instruction and practical experience in generating research designs, conceptual frameworks, and reviews of literature using Augmented Reality (AR) interactive contents. We followed the seven characteristic features of co-design as outlined by Roschelle et al. (2006) and structured sessions for co-design in accordance with Cober et al. (2015) and Barberá et al.’s (2017) proposed stages: a) Exploration, b) Envisioning, c) Operationalization, and d) Assessment and Reflection.
Successful implementation of the co-designed lessons and their integration with the IRML as a technological learning resource highlight the affordances of using a co-design approach to confront the inherent challenges in designing authentic and meaningful learning experiences when teaching research methods.
Synthesis of Some New Heterocyclic Azo Dyes Derived from 2-amino-3-cyano-4.6- diarylpyridines and Investigation of its Absorption Spectra and Stability using the DFT
Authors: Abdelrehim El-Sayed M. 
Published: December 2020

Introduction:
In continuation of our interest in 2-amino-3-cyano-4.6-diarylpyridines reactions in various
fields of organic chemistry which were previously used for the synthesis of many heterocyclic compounds
and where dyes generally have many applications especially when benzene or anthraquinone azo dyes are replaced
with heterocyclic azo dyes so new derivatives of heterocyclic azo dyes derived from 2-amino-3-cyano-
4.6-diarylpyridines were prepared.

Materials and Methods:
The IR spectra (KBr), NMR, elemental microanalyses and mass spectra, were performed
at different faculties of science in Egypt. Absorption spectra were recorded on Unicam SP 750 in DMF
and acetone using 1x 10-5 mol l-1 of dye concentration. Optimization was performed using density functional theory
(DFT) and time dependent-DFT by applying Becke’s three-parameter hybrid exchange functional with Lee–
Yang–Parr gradient-corrected correlation (B3LYP functional). The chemical reagents used in the synthesis were
purchased from Fluka, Sigma and Aldrich.

Result and Discussions:
The structure of the preparing Heterocyclic azo dyes is proven using spectroscopic tools
and elemental analysis, and investigation of its absorption spectra indicate the effect of both solvent and substituent
on absorption maximum. DFT calculations were performed on some of the selected dyes.

Conclusion:
Structures of newly synthesized heterocyclic azo dyes were confirmed using elemental analysis, IR,
1H-NMR, 13C-NMR and mass spectral data. DFT theory was used in explaining the electronic properties of some
selected dyes, where the energy gap can help in understanding the reactivity behaviour and stability of these
compounds. Absorption spectra indicate the effect of both solvent and substituent on absorption maximum.
Numerical Investigation of Innovative Support Frame of Openings in the Segmental Tunnel Lining
Authors: Ebrahimi Sanaz , Hadei Mir Raouf , Rashiddel Alireza , Hajihassani Mohsen 
Published: December 2020

Introduction:
To supply safety in the tunnels, it is necessary to construct escape routes and emergency exits that are performed by locating cross passages.

Methods:
These passages connect two tunnels transversely and apply escape routes. Using temporary steel structures to supply the ring stability in practice and reinforced concrete frame to stabilize the ring permanently can be appropriate to form a solid frame that transfers the opened ring's load to the opening surroundings. In this paper, a 3D finite element simulation was performed to analyze the influence of opening construction in the segmental concrete lining and a temporary support system. Using the simulation, stress and deformation distribution of the steel frame, bolts, and segmental lining were obtained.

Results:
The results show that by increasing the number of bolts from 18 to 30, the induced stress in the steel frame and bolts decreased to 76 and 59 percent, respectively. In addition, the maximum displacement in the segmental lining and the maximum opening value of the joints decline to 62.7 and 75 percent, respectively.

Conclusion:
Finally, it can be concluded that the steel frame can be used as a temporary support system.
PEMBERDAYAAN KELOMPOK WANITA TANI SUMBER BOGA MENGOLAH LIDAH BUAYA MENJADI MINUMAN LIDAH BUAYA SEBAGAI SUMBER VITAMIN MINERAL PENUNJANG PERTUMBUHAN PERKEMBANGAN BALITA
Authors: Ngaisyah Dewi , Adiputra Andre Kussuma , Mindarsih Eko 
Published: December 2020

Dusun Tamanan telah memiliki kelompok usaha pembudidayaan lidah buaya. Pembudidayaan lidah buaya dikelola oleh KWT Sumber Boga. Hasil pembudidayaan lidah buaya menjadi potensi yang dapat dikembangkan menjadi makanan sumber vitamin dan mineral. Pertumbuhan dan perkembangan ditunjang dari konsumsi makanan yang tinggi konsentrasi vitamin dan mineral dari bahan alamiah. Masih dijumpai balita yang tidak terpenuhi zat gizi makro terlihat adanya defisiensi gizi mikro yang dialami balita. Defisiensi gizi mikro menyebabkan keterlambatan pertumbuhan dan perkembangan. Makanan sumber vitamin dan mineral banyak alternatif yang dapat dibudidayakan tumbuh subur dilahan pekarangan salah satunya adalah tanaman lidah buaya. Tanaman lidah buaya akan diolah menjadi produk minuman sebagai sumber vitamin dan mineral. Pemberdayaan dilakukan melalui kegiatan pelatihan dan pendampingan. Dampak kegiatan pemberdayaan melalui pengukuran terhadap pengetahuan dan konsumsi vitamin mineral mineral balita. Hasil Kegiatan pengabdian masyarakat ini dapat memberikan solusi dari permasalahan pengolahan lidah buaya dan permasalahan Kesehatan yang dihadapi Dusun Tamanan, Taman Martani, Sleman, Yogyakarta.
PENERAPAN HUKUM BERNOULLI PADA KONSEP PERANCANGAN GALERI PESAWAT TERBANG DAN KANTOR SEWA DI KEMAYORAN
Authors: Febrianto Willy Steven , Lianto Fermanto 
Published: December 2020

Along with the times, the Kemayoran area changed its function to become an office area, so that the history of Kemayoran is increasingly eroded. However, we cannot refuse the current of the times, especially the Kemayoran area, which has the potential to become a Central Business District (CBD). After searching the data by conducting interviews and surveys in the Kemayoran area and reviewing the literature, the urban acupuncture theory is used to answer the phenomenon that occurs, namely an aircraft history gallery and the additional function of the rental office will be used as an educational tourist spot where people can see various collections of aircraft from the Dutch, Japanese and Indonesian colonial times, and to fulfill Kemayoran's function as a CBD area. This building has a design concept taken from Bernoulli's law which is the movement of air as it passes through the wings of an aircraft and has a theme of aerospace. This gallery and rental office will be supported by programs such as movie showrooms, libraries, airplane exhibition rooms with a scale of 1:1, and workshops. With this building, it is hoped that the history of Kemayoran can be widely known by all circles and become a means of education, especially for the younger generation. Keywords: Airplane; Bernoulli; Gallery; Rental Office; Urban AcupunctureABSTRAKSeiring perkembangan zaman, daerah Kemayoran berubah fungsi menjadi daerah perkantoran, sehingga sejarah Kemayoran semakin lama semakin tergerus. Namun, kita tidak dapat menolak arus perkembangan zaman, terlebih daerah Kemayoran yang memiliki potensi menjadi daerah Central Business District (CBD). Setelah melakukan pencarian data dengan melakukan wawancara dan survei di kawasan Kemayoran serta mengkaji literatur, maka digunakan teori urban acupuncture untuk menjawab fenomena yang terjadi, yaitu sebuah galeri sejarah pesawat terbang dan fungsi tambahan kantor sewa akan dijadikan sebuah tempat wisata edukasi dimana orang-orang dapat melihat berbagai koleksi pesawat dari zaman penjajahan Belanda, Jepang, dan saat Indonesia merdeka, serta untuk memenuhi fungsi Kemayoran sebagai daerah CBD. Bangunan ini memiliki konsep perancangan yang diambil dari hukum Bernoulli yakni pergerakan udara saat melewati sayap pesawat dan memiliki tema kedirgantaraan. Galeri dan kantor sewa ini akan didukung dengan progam seperti ruang pertunjukan film, perpustakaan, ruang eksibisi pesawat dengan skala 1:1, dan workshop. Dengan adanya bangunan ini, diharapkan sejarah Kemayoran dapat dikenal luas oleh semua kalangan dan menjadi sarana edukasi khususnya bagi generasi muda.
The Reality of Medicine Use in the Department of Tropical Diseases at E hospital from 10/2019 to 3/2020
Authors: Thi Xuan Bui , Thi Thu Hoai Bui , Thi Lan Huong Le 
Published: December 2020

This paper analyzes the use of medicines in the Department of Tropical Diseases at E Hospital. The analysis shows that 100% of the medical records were completely and clearly filled out with the patient’s name, age, gender, address and clear information about the medicines, their concentrations and routes of administration. However, there were some deficiencies in administrative procedures, such as 7.75% of the medical records abbreviated the main diagnosis, 94.75% of them did not prescribe medicines according to their routes of administration. The average number of medicines per person per day was 5.04 and the average treatment time was 5.85 days. Notably, the percentage of the medical records with prescription of injectable medicines was remarkably high (98.75%).
Keywords
Medicine use, Department of Tropical Diseases, E hospital.
References
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Konteks Kemunculan Kata-Kata Baru Bahasa Indonesia dan Bahasa Jepang dalam Situasi Wabah Covid-19
Authors: Takao Urano 
Published: December 2020

Sejak awal tahun 2020, virus corona bentuk baru/covid-19 telah menyebar di seluruh dunia. Hal ini mengakibatkan ancaman besar terhadap masyarakat di seluruh dunia. Ancaman wabah covid-19 telah mengubah gaya hidup manusia seiring merebaknya penyakit menular ini, hingga begitu berdampak terhadap perekonomian dunia. Bersamaan dengan situasi covid-19 yang belum pernah dialami, muncul berbagai kata baru dan mengakar pada masyarakat dalam kehidupan sehari-hari. Oleh karena itu, dalam artikel ini, peneliti ingin mengeksplorasi arti dan konsep kata-kata baru tersebut sambil membandingkannya dalam bahasa Indonesia dan bahasa Jepang serta mengkaji bagaimana kata-kata baru tersebut lahir dan tersebar. Situasi covid-19 merupakan fenomena yang terus berlanjut. Ada kemungkinan situasi akan terus berubah antara waktu penulisan artikel ini dengan situasi waktu ke depan. Oleh karena itu, peneliti berharap meskipun artikel ini masih dalam proses penelitian, semoga dapat berlanjut pada pendalaman penelitian berikutnya.
Kata kunci: covid-19; kata baru bahasa Indonesia; kata baru bahasa Jepang; sosiolinguistik