bluuebunny/crossref_metadata_2025_split huggingface dataset:
Happiness as a driver of entrepreneurial initiative and innovation capital
Authors: Usai Antonio , Orlando Beatrice , Mazzoleni Alberto 
Published: July 2020

PurposeThis study aims to extend the knowledge in the domain of intellectual capital and entrepreneurship by investigating whether happiness may have a positive influence on entrepreneurial initiative and intellectual property or not.Design/methodology/approachThe used large-scale dataset for 2018 is drawn from the Eurostat. It includes information on individual happiness, sustainability, start-ups, creativity, intellectual property and quality of life, grouped by European countries. Hypotheses are tested through using the linear regression method.FindingsThe findings confirm that happiness, along with creativity, fosters both entrepreneurial initiative and intellectual property.Research limitations/implicationsFuture studies should test the model by extending the analysis to different world regions and by considering further variables, such as country culture.Practical implicationsThe study suggests that policy makers have to focus on improving life conditions and sustainability as a means to foster local economies and communities.Originality/valueThis cutting-edge study is unique in its genus, because the prior literature never focused on these topics jointly. At an academic level, it ties happiness to creativity and to “the entrepreneurial spirit”, thus opening up to a new and vast domain of researches.
Integrated sustainable supply chain management and firm performance in the Indian textile industry
Authors: Shahi Shashi K. , Shiva Atul , Dia Mohamed 
Published: July 2020

PurposeThis research study explores the adoption of integrated sustainable SCM practices in the textile industry in India and its impact on the firm's business performance.Design/methodology/approachThe analysis was carried out using the partial least squares structural equation modeling using SmartPLS 3.3.2.FindingsIt was found that the demand-side sustainability initiatives of the large firms and the internal sustainability practices of the small firms directly impacted their business performance. It was also found that the suppliers' sustainability initiatives had a direct and positive impact on the internal sustainability of the firm, which in turn had a direct and positive impact on the demand-side sustainability in the Indian textile industry.Originality/valueThe findings emphasize the distinctive role of each dimension of the integrated sustainable SCM on the firm performance in the Indian textile industry.
Modulation of bleomycin‐induced oxidative stress and pulmonary fibrosis by N‐acetylcysteine in rats via AMPK/SIRT1/NF‐κβ
Authors: Mansour Heba H. , Omran Mervat M. , Hasan Hesham F. , El kiki Shereen M. 
Published: July 2020

AbstractThe efficacy of bleomycin (BLM) as an antineoplastic drug is limited to the development of dose and time‐dependent pulmonary fibrosis. This study was intended to investigate the effect of N‐acetylcysteine (NAC) on BLM‐induced pulmonary fibrosis in rats. Twenty rats were randomly divided to the following four groups: Group one served as control; group two received BLM (15 mg/kg, intraperitoneal (ip)) for five consecutive days; group three received NAC (200 mg/kg, ip) for five consecutive days; and group four received NAC 1 hour before BLM for 5 days. The expression of connective tissue growth factor (CTGF), platelet‐derived growth factor (PDGF), silent information regulator l (SIRT1), AMP‐activated protein kinase (AMPK) were determined by qRT‐PCR in lung tissues. The changes in transforming growth factor‐beta1 (TGF‐β1), tumour necrosis factor‐α (TNF‐α), interleukin‐β1 (IL‐β1) and nuclear factor kappa‐β (NF‐κβ) in serum were measured by ELISA. The tissue antioxidant status was determined biochemically. BLM administration caused pulmonary fibrosis as evidenced by increased levels of inflammatory mediators (TGF‐β1, TNF‐α, IL‐β1 and NF‐κβ) in serum (P < .05), elevated lipid peroxidation and nitric oxide and depleted endogenous antioxidants in lung tissue (P < .05). The expression levels of SIRT1 and AMPK were significantly decreased (P < .05), while the expression levels of CTGF and PDGF were increased significantly in the BLM group as compared to the control group (P < .05). These alterations were normalized by NAC intervention. NAC markedly attenuated the lung histopathological changes and reduced collagen deposition. These results suggest that NAC exerted an ameliorative effect against BLM‐induced oxidative damage and pulmonary fibrosis via SIRT1/ AMPK/ NF‐κβ pathways.
Dual transcriptomics and proteomics analyses of the early stage of interaction between Caballeronia mineralivoransPML1(12) and mineral
Authors: Uroz Stéphane , Picard Laura , Turpault Marie‐Pierre , Auer Lucas , Armengaud Jean , Oger Phil 
Published: July 2020

SummaryMinerals and rocks represent essential reservoirs of nutritive elements for the long‐lasting functioning of forest ecosystems developed on nutrient‐poor soils. While the presence of effective mineral weathering bacteria was evidenced in the rhizosphere of different plants, the molecular mechanisms involved remain uncharacterized. To fill this gap, we combined transcriptomic, proteomics, geo‐chemical and physiological analyses to decipher the potential molecular mechanisms explaining the mineral weathering effectiveness of strain PML1(12) of Caballeronia mineralivorans. Considering the early‐stage of the interaction between mineral and bacteria, we identified the genes and proteins differentially expressed when: (i) the environment is depleted of certain essential nutrients (i.e., Mg and Fe), (ii) a mineral is added and (iii) the carbon source (i.e., glucose vs mannitol) differs. The integration of these data demonstrates that strain PML1(12) is capable of (i) mobilizing iron through the production of a non‐ribosomal peptide synthetase‐independent siderophore, (ii) inducing chemotaxis and motility in response to nutrient availability and (iii) strongly acidifying its environment in the presence of glucose using a suite of GMC oxidoreductases to weather mineral. These results provide new insights into the molecular mechanisms involved in mineral weathering and their regulation and highlight the complex sequence of events triggered by bacteria to weather minerals.
Neoliberalism and the punitive turn in Southeast Asia and beyond: implications for gender, sexuality, and graduated pluralism
Authors: Peletz Michael G. 
Published: July 2020

AbstractAnthropologists and other scholars have explored the elective affinities between neoliberal globalization and punitive turns in both legal and more expansive cultural‐political domains, particularly in Western settings such as the United States, the United Kingdom, and France. This article expands the discussion by engaging these affinities in late modern Southeast Asia, especially the Muslim‐majority nations of Malaysia and Indonesia. One goal of the article is to describe and analyse the constriction of pluralism with respect to gender and sexuality, a key feature of the surge in punitiveness in many societies in Southeast Asia and elsewhere. Others include elucidating similarities and differences between trends in Southeast Asia and the new punitiveness we have seen in the United States in recent decades, and highlighting some of the comparative and theoretical implications of my arguments.
Parents' experiences of care and support after stillbirth in rural and urban maternity facilities: a qualitative study in Kenya and Uganda
Authors: Mills TA , Ayebare E , Mukhwana R , Mweteise J , Nabisere A , Nendela A , Ndungu P , Okello M , Omoni G , Wakasiaka S , Wood R , Lavender T 
Published: July 2020

ObjectiveTo explore parents' lived experiences of care and support following stillbirth in urban and rural health facilities.DesignQualitative, interpretative, guided by Heideggerian phenomenology.SettingNairobi and Western Kenya, Kampala and Central Uganda.SampleA purposive sample of 75 women and 59 men who had experienced the stillbirth of their baby (≤1 year previously) and received care in the included facilities.MethodsIn‐depth interviews, analysed using Van Manen's reflexive approach.ResultsThree main themes were identified; parents described devastating impacts and profound responses to their baby's death. Interactions with health workers were a key influence, but poor communication, environmental barriers and unsupportive facility policies/practices meant that needs were often unmet. After discharge, women and partners sought support in communities to help them cope with the death of their baby but frequently encountered stigma engendering feelings of blame and increasing isolation.ConclusionsParents in Kenya and Uganda were not always treated with compassion and lacked the care or support they needed after the death of their baby. Health workers in Kenya and Uganda, in common with other settings, have a key role in supporting bereaved parents. There is an urgent need for context and culturally appropriate interventions to improve communication, health system and community support for African parents.Tweetable AbstractHealth‐system response and community support for parents after stillbirth in Kenya and Uganda are inadequate.
Adaptation May Reduce Climate Damage in Agriculture by Two Thirds
Authors: Huang Kaixing , Sim Nicholas 
Published: July 2020

AbstractAlthough climate change may severely impact agriculture, farmers can mitigate it by adapting. Using US data, we estimate the amount of potential loss in agricultural profits, due to climate change, that can be reduced by agricultural adaptation. We consider two panel frameworks that differ only in their fixed effects specifications, where this difference allows us to estimate the climate change impact on agricultural profits with or without adaptation. Comparing these estimates, we find that adaptation has the potential to offset about two‐thirds of the end‐of‐century loss in agricultural profits potentially resulting from climate change. We also find that the warmest region in the US (i.e. in the south) has the most to gain from adaptation.
The role of tumour biomarkers in choosing the appropriate positron emission tomography imaging in follow‐up of medullary thyroid cancer
Authors: Şahin Ertan , Elboğa Umut 
Published: July 2020

AbstractIntroductionWe aimed to demonstrate the importance of serum calcitonin (Ct) and carcinoembryonic‐antigen (CEA) levels in the selection of appropriate positron emission tomography/computed tomography (PET/CT) modality in the follow‐up of operated patients with medullary thyroid cancer.MethodsFourteen operated patients (8 Female, 6 Male) with MTC underwent PET/CT imaging with somatostatin (68Ga‐DOTATATE) and glucose (18FDG) analogs due to elevated Ct or CEA at follow‐up. Ct and CEA levels and both PET/CT findings were compared based on both patients and lesions.ResultsPositive findings were found in 10 patients with 68Ga‐DOTATATE‐PET/CT and in 8 patients with 18FDG‐PET/CT, and sensitivity was found as 71.4% and 57.1% for both imaging methods, respectively (P > 0.05). Lesion could be detected with 68Ga‐DOTATATE‐PET/CT in 3 patients in whom lesion could not be detected with 18FDG‐PET/CT. In one patient, whereas no pathological lesion was with 68Ga‐DOTATATE‐PET/CT, lesion could be detected with 18FDG‐PET/CT in this patient. Of the total 67 lesions, 62 could be shown with 68Ga‐DOTATATE‐PET/CT, while 48 lesions could be detected with 18FDG‐PET/CT (P < 0.05). A statistically significant positive correlation was found between Ct level and the number of lesions detected on the 68Ga‐DOTATATE‐PET/CT, and similarly between CEA level and the number of lesions detected on the 18FDG‐PET/CT.ConclusionsIt was found that 68Ga‐DOTATATE‐PET/CT is superior over 18FDG‐PET/CT method in detection of recurrent disease in the follow‐up of MTC, and serum Ct and CEA levels are important biomarkers in the selection of appropriate PET/CT modality.
Comparing two airway management strategies for moderately sedated patients undergoing awake craniotomy: A single‐blinded randomized controlled trial
Authors: Deng Meng , Tu Meng‐Yun , Liu Yi‐Heng , Hu Xiao‐Bing , Zhang Tao , Wu Jin‐Song , Wang Ying‐Wei 
Published: July 2020

AbstractBackgroundIn the monitored anesthesia care (MAC) setting for awake craniotomy (AC), maintaining airway patency in sedated patients remains challenging. This randomized controlled trial aimed to compare the validity of the below‐epiglottis transnasal tube insertion (the tip of the tube placed between the epiglottis and vocal cords) and the nasopharyngeal airway (simulated by the above‐epiglottis transnasal tube with the tip of the tube placed between the epiglottis and the free edge of the soft palate) with respect to maintaining upper airway patency for moderately sedated patients undergoing AC.MethodsSixty patients scheduled for elective AC were randomized to receive below‐epiglottis (n = 30) or above‐epiglottis (n = 30) transnasal tube insertion before surgery. Moderate sedation was maintained in the pre‐ and post‐awake phases. The primary outcome was the upper airway obstruction (UAO) remission rate (relieved obstructions after tube insertion/the total number of obstructions before tube insertion).ResultsThe UAO remission rate was higher in the below‐epiglottis group [100% (12/12) vs 45% (5/11); P = .005]. The tidal volume values monitored through the tube were greater in the below‐epiglottis group during the pre‐awake phase (P < .001). End‐tidal carbon dioxide (EtCO2) monitored through the tube was higher in the below‐epiglottis group at bone flap removal (P < .001). During the awake phase, patients' ability to speak was not impeded. No patient had serious complications related to the tube.ConclusionThe below‐epiglottis tube insertion is a more effective method to maintain upper airway patency than the nasopharyngeal airway for moderately sedated patients undergoing AC.
The accuracy of periapical radiography and cone beam computed tomography in measuring periodontal ligament space: Ex vivo comparative micro‐CT study
Authors: Tayman M. Ayşe , Kamburoğlu Kıvanç , Öztürk Ebru , Küçük Özlem 
Published: July 2020

AbstractOur aim was to measure PDL space width using periapical radiography, CBCT and micro‐CT. Dry human mandibular bones (n = 36) consisting of 59 molar and 36 premolar teeth were used. Four image sets were obtained as follows: (i) photostimulable phosphor plate (PSP), periapical radiography, (ii) CBCT 0.075 mm voxel size, (iii) CBCT 0.2 mm voxel size and (iv) micro‐CT 0.06 mm voxel size. Micro‐CT images were considered as the gold standard. Four observers measured the PDL space widths twice. Intra‐ and interclass correlation coefficients (ICC) were calculated. Spearman’s rho correlation was assessed. PDL space widths ranged between 0.16 and 0.28 mm. There was good reliability within and between observers (P < 0.01). There was no significant relationship between micro‐CT and periapical imaging. (P > 0.05). Best observer performance was obtained from CBCT 0.075 mm voxel size images followed by CBCT 0.2 mm voxel size images.
Impact of Ethiopia's productive safety net program on manure use by rural households: Evidence from Tigrai, Northern Ethiopia
Authors: Araya Girmay Berhe 
Published: July 2020

AbstractAlthough development intervention programs can have far‐reaching impacts beyond their stated objective, there have been few careful studies on associated but unintended outcomes of such programs. This study assesses the impact of membership in the public works component of Ethiopia's productive safety net program (PSNP) on whether households use manure and the amount of it they use. This is done using the double‐hurdle method based on survey data of 2015 on 11 agro‐climatically diverse districts of the Tigrai region in Northern Ethiopia. Results show that PSNP member households are not different from their nonmember counterparts in terms of manure use. This may indicate that PSNP is helping member households catch up with nonmember households in terms of manure use, even though they have smaller livestock ownership. This might indicate that PSNP member households are becoming more aware of the benefits of using manure, and hence are using available manure more efficiently. Therefore, this could be taken as one additional positive contribution of the PSNP in Ethiopia's endeavor to improve food security of poor rural farm households by increasing their productivity.
Spatial and temporal overlap of caracal and serval in Serengeti National Park, Tanzania
Authors: Mwampeta Stanslaus B. , Magige Flora J. , Belant Jerrold L. 
Published: July 2020

AbstractUnderstanding activity and habitat use are important for identifying mechanisms facilitating species co‐occurrence. We studied habitat use and activity patterns of caracals (Caracal caracal) and servals (Leptailurus serval), primarily nocturnal, mid‐sized felids that prey extensively on small mammals and co‐occur in portions of sub‐Saharan Africa. Spatial and temporal patterns of segregation were investigated in a 1,085‐km2 area of Serengeti National Park, Tanzania from 2010–2012. We used occupancy analysis to quantify habitat use and kernel density estimators and Mardia–Watson–Wheleer tests to analyse activity patterns. We found evidence for habitat divergence but high temporal overlap between species. Servals selected for grassland and avoided shrubland and wooded grassland. In contrast, the findings showed that caracals avoided grassland and woodland–shrubland; however, 73% of caracals were detected in wooded grassland. Overall, caracals and servals co‐occurred independently, Species Interaction Factor, (phi = 1). This indicates that differential use of habitats in part facilitated coexistence of caracals and servals. Proper management of the declining grasslands including other habitats are recommended to facilitate continued coexistence. Additional studies, including feeding ecology, would be important to further understand mechanisms facilitating coexistence between caracals and servals.
SARS‐CoV‐2, COVID‐19, skin and immunology – What do we know so far?
Authors: Novak Natalijia , Peng Wenming , Naegeli Mirjam C. , Galvan Christina , Kolm‐Djamei Isabel , Brüggen Charlotte , Cabanillas Beatriz , Schmid‐Grendelmeier Peter , Catala Alba 
Published: July 2020

AbstractThe pandemic condition coronavirus disease (COVID‐19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can take asymptomatic, mild, moderate, and severe courses. COVID‐19 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatigue, and diarrhea and can end up in interstitial pneumonia and severe respiratory failure. Reports about the manifestation of various skin lesions and lesions of the vascular system in some subgroups of SARS‐CoV‐2‐positive patients as such features outside the respiratory sphere, are rapidly emerging. Vesicular, urticarial, and maculopapular eruptions and livedo, necrosis, and other vasculitis forms have been reported most frequently in association with SARS‐CoV‐2 infection. In order to update information gained, we provide a systematic overview of the skin lesions described in COVID‐19 patients, discuss potential causative factors, and describe differential diagnostic evaluations. Moreover, we summarize current knowledge about immunologic, clinical, and histologic features of virus‐ and drug‐induced lesions of the skin and changes to the vascular system in order to transfer this knowledge to potential mechanisms induced by SARS‐CoV‐2.
Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation
Authors: Li Kun , Sun Peibei , Wang Yayan , Gao Tian , Zheng Dongwang , Liu Ajuan , Ni Ya 
Published: July 2020

AbstractBackgroundHeat shock protein 90 (Hsp90) signaling pathways participate in protein phosphorylation during sperm capacitation. However, the underlying mechanism is largely unknown.ObjectiveThe aim of this study was to explore the interaction between Hsp90 and its co‐chaperone protein, cell division cycle protein Cdc37 (Cdc37), in human spermatozoa.Materials and methodsWe examined the effects of H‐89 (a protein kinase A [PKA] inhibitor) and Go6983 (a protein kinase C [PKC] inhibitor) on the phosphorylation of serine, threonine, and tyrosine residues in Hsp90; the effect of 17‐allylamino‐17‐demethoxygeldanamycin (17‐AAG, Hsp90 inhibitor) on Y416‐Src phosphorylation; and the effects of 17‐AAG and geldanamycin on threonine phosphorylation during human sperm capacitation.ResultsHsp90 co‐localized and interacted with Cdc37. During human sperm capacitation, Hsp90 phosphorylation at serine, threonine, and tyrosine residues was inhibited by H‐89 and Go6983. In addition, phosphorylation of residue Y416 in the tyrosine kinase Src (its active site) was inhibited by 17‐AAG, and the threonine phosphorylation levels of some proteins were decreased by 17‐AAG and geldanamycin.Discussion and conclusionTaken together, our data showed that the interaction of Hsp90 with Cdc37 regulates total protein threonine phosphorylation and Src phosphorylation via its serine, threonine, and tyrosine phosphorylation, which are controlled by PKA and PKC during human sperm capacitation. The results of this study help understand the mechanism underlying Hsp90 regulation of sperm function.
Letter: moderate levels of serum hepatitis B virus DNA alone are not associated with increased risk of hepatocellular carcinoma in chronic hepatitis B patients. Authors' reply
Authors: Kim Gi‐Ae , Lim Young‐Suk 
Published: July 2020

LINKED CONTENTThis article is linked to Kim et al and Kumar and Mishra papers. To view these articles, visit
https://doi.org/10.1111/apt.15725 and https://doi.org/10.1111/apt.15829.
Randomised clinical trial: oesophageal radiofrequency energy delivery versus sham for PPI‐refractory heartburn
Authors: Zerbib Frank , Sacher‐Huvelin Sylvie , Coron Emmanuel , Coffin Benoit , Melchior Chloé , Ponchon Thierry , Cholet Franck , Chabrun Edouard , Vavasseur Fabienne , Gorbatchef Caroline , Zalar Alberto , Mion François , Robaszkiewicz Michel , Le Rhun Marc , Leroy Maxime , Paul Galmiche Jean , Bruley des Varannes Stanislas 
Published: July 2020

SummaryBackgroundOesophageal radiofrequency reduces use of proton pump inhibitors (PPIs) in patients with gastro‐oesophageal reflux disease responding to PPIs.AimTo determine the efficacy of oesophageal radiofrequency in patients with PPI‐refractory heartburn.MethodsA randomised, double‐blind, sham‐controlled multicentre study was designed to assess the efficacy of oesophageal radiofrequency in PPI non‐responding patients with heartburn. Patients had moderate‐to‐severe heartburn defined by at least 3 occurrences a week, and not improved by continuous PPI treatment. The primary endpoint was clinical success at week 24, defined by intake of less than 7 PPI doses over the 2 preceding weeks and adequate symptom control determined by the patient.ResultsSixty two patients were randomised, 29 to the oesophageal radiofrequency group and 33 to the sham group. Intention‐to‐treat analysis showed that 1/29 (3.4%) and 5/33 (15.1%) achieved the primary endpoint in the oesophageal radiofrequency and sham groups, respectively (NS). There was no significant difference between oesophageal radiofrequency and sham regarding the number of days without heartburn, days with PPI consumption in the last 2 weeks, and patients not taking PPIs. No pH‐impedance parameter was associated with clinical response. The occurrence of adverse events was similar in both groups.ConclusionThis sham‐controlled, randomised study did not demonstrate any efficacy of oesophageal radiofrequency for the treatment of PPI‐refractory heartburn regarding symptom relief or consumption of PPIs. ClinicalTrials.gov NCT01682265.