bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naphthalimide Dyes with Orthogonal Functional Groups for “Click” Chemistry: Attachment to Solid Supports and Applications in Drug Allergy Diagnosis
Authors: Ruiz‐Sanchez Antonio J. , Collado Daniel , Mayorga Cristobalina , Torres Maria J. , Perez‐Inestrosa Ezequiel 
Published: March 2020

AbstractThe preparation and characterization of new functional materials for sensing have an important role in clinical diagnosis. Monitoring the surface functionalization of functional material is crucial because the final sensing properties are affected by how the (bio)molecules are immobilized on the surface of solid supports. Here, a new approach for the preparation of functional materials for biomedical diagnosis was developed. This method employs a fluorescent dye comprising 4‐amino‐1,8‐naphthalimide with two orthogonal functional groups suitable for click chemistry. The orthogonal reactivity of these groups allows the sequential functionalization of the fluorophore, firstly with (bio)molecules, and then binding of the (bio)molecule‐naphthalimide macrostructure onto the surface of a solid support. The fluorescent properties confirm the immobilization of the (bio)molecule on the surface of the solid support, without requiring other indirect methods to verify the immobilization. These functional materials were tested successfully with sera of patients, thus proving their potential application for allergic drug diagnosis.
Chlamydia trachomatis in the gingival sulcus and pharynx in patients of Northeast Mexico
Authors: Coronado‐Cerda Erika E. , Ancer‐Rodríguez Jesus , Montemayor‐Martínez Raul , Canabal‐Hermida Fabrizio , Gallegos‐Avila Guadalupe , De la Garza‐Ramos Myriam A. 
Published: March 2020

AbstractBackgroundThe oral microenvironment provides the conditions for the establishment of microorganisms not usually considered residents of the normal oral microbiota. Sexually transmitted microorganisms such as Chlamydia trachomatis can adhere to any mucosal surface and ascend to reach appropriate locations to survive and develop symptomatic infections.Materials and methodsTo determine the presence of C. trachomatis, direct immunofluorescence of this microorganism was carried out in 76 randomly selected patients attending a periodontal clinic during a period of 1 year. Samples from the gingival sulcus and the pharynx were collected for detection of C. trachomatis. Patients who attended the periodontal clinic were divided into two groups: those without periodontitis and those with periodontitis. For the purpose of performing other statistical analyses, all patients were also divided by gender and age.ResultsFrom the total of 76 patients, in the group without periodontitis, 61% were positive for C. trachomatis in the gingival sulcus and 63.4% in the pharynx; in the periodontitis group, 45.7% were positive in the sulcus and 40% in the pharynx. When we compared patients by gender or age, no statistical difference was found.ConclusionsThe prevalence of C. trachomatis in this group was 53.9% in the gingival sulcus and pharynx of the studied patients.
Characterization of post‐haustorial resistance to sunflower broomrape
Authors: Martín‐Sanz Alberto , Pérez‐Vich Begoña , Rueda Sandra , Fernández‐Martínez José M. , Velasco Leonardo 
Published: March 2020

AbstractThe development of durable resistance to broomrape (Orobanche cumana Wallr.) in sunflower (Helianthus annuus L.) requires detailed characterization of the genetic and physiological bases of resistance. The objective of the present study was to map the resistance gene accurately, and to characterize the mechanism of resistance to broomrape observed in a sunflower inbred line (PHSC1102). PHSC1102, which was consistently resistant against race F and race G populations of broomrape, was crossed with PHSC1201, which was susceptible to races F and G. A mapping population of 150 F2 genotypes was phenotyped by evaluating F2:3 families for resistance to broomrape races FGV and GTK. The use of single nucleotide polymorphism (SNP) markers mapped the OrSII gene to Linkage Group 4 (LG4) of the sunflower genome. Mini‐rhizotron and histological studies of the resistant line revealed that the attachment of broomrape to host roots was similar in both the resistant and susceptible lines and that the resistance was observed at a late stage (i.e., after tubercle development). Interestingly, the resistance of the PHSC1102 line was associated with the production of phenolic compounds, which were hypothesized to restrict the parasite's growth. This research provides novel and valuable information about the host–parasite interactions between sunflower and broomrape.
Exploring the QTL–allele constitution of main stem node number and its differentiation among maturity groups in a Northeast China soybean population
Authors: Fu Mengmeng , Wang Yanping , Ren Haixiang , Du Weiguang , Yang Xingyong , Wang Deliang , Cheng Yanxi , Zhao Jinming , Gai Junyi 
Published: March 2020

AbstractNortheast China (NEC) is a major soybean [Glycine max (L.) Merr.] production region in China, where the germplasm of American soybeans are mainly from. The main stem node number (MSN) is a trait related to plant type and yield potential. With the soybeans expanded to higher latitudes in NEC, earlier maturity groups (MG 0, MG 00, and MG 000) formed based on MG I + MG II (MG I+II), and correspondingly the MSN decreased. To explore the MSN quantitative trait locus (QTL)–allele constitution, 306 accessions from NEC were studied using the restricted two‐stage multilocus genome‐wide association study (RTM‐GWAS) procedure. In total, 76 MSN QTLs and 183 alleles were identified, with their genetic contribution about 0.04–9.83% per locus for a total of 65.63% for all loci. With the MSN reduction from MG I+II to MG 0, MG 00, and MG 000 (17.89 to 13.11), the changed alleles accounted for 28.42% of all alleles (6.56% for new allele emergence plus 21.86% for old allele exclusion), whereas the major part of the alleles were those inherited from MG I+II (71.58%). Thus in the evolution of MSN in the NEC soybean population, inheritance is the first genetic motivation, exclusion and selection (positive allele exclusion, 65.00%) is the second, emergence and mutation (negative allele emergence, 95.67%) is the third, and recombination among retained alleles is the fourth. A potential of 2–5 MSN improvement keeping the MG earliness was predicted, and 49 candidate genes were identified.
Family × environment interaction for sugarcane yield and its components in South Africa
Authors: Mbuma Ntombokulunga W. , Zhou Marvellous M. , van der Merwe Rouxlene 
Published: March 2020

AbstractIn sugarcane (Saccharum spp. hybrids) breeding, knowledge of progeny performance and adaptability increases crossing and selection efficiency. Family evaluation across environments uses progeny data to determine family genetic values and family × environment interactions. The objectives were to determine family × environment breeding parameters, family values across locations, and contribution of yield components to cane yield of families in different environments. Data were collected from the plant, first ratoon, and second ratoon crops of 44 families made from 18 female and 18 male parents and planted in the Midlands (24 mo harvest), coastal (12–18 mo), and irrigated (12 mo) environments. Cane yield was estimated from stalk number, stalk height, and stalk diameter, measured from the first 20 plants per family plot. Significant (P < .01) family variance for cane yield traits indicated genetic variability among the families. Significant (P < .01) family × location variance for cane yield, stalk number, and diameter indicated that the magnitude of genetic variability among families was influenced by location. The nonsignificant (P > .05) family × crop year and family × location × crop year variances indicated similar genetic variability across crop years. Therefore, testing families in multiple locations was more important than across crop years. Best linear unbiased predictor estimates showed that families TT1051, UU0332, and UU0312 had significantly higher cane yield across locations and, therefore, were broadly adapted. VV0701 (irrigated), VV0390 (Midlands), and UU0198 (Midlands) produced greater cane yield and showed location‐specific adaptability. The irrigated, coastal, and Midlands populations showed higher specific adaptability for cane yield and stalk height.
Multitrait differential response in a diverse potato panel under contrasting water regimes
Authors: Tagliotti Martin E. , Bedogni María C. , Cendoya María G. , Ortego Jaime , Huarte Marcelo A. 
Published: March 2020

AbstractWater stress is the most significant environmental stress in agriculture worldwide. Potato (Solanum tuberosum L.) is a drought‐susceptible crop. Water stress tolerance is a complex trait of increasing importance in potato. The objective of this work was to evaluate the differential response strategies associated with water stress tolerance in a highly diverse potato panel. Multienvironment trials were assessed, both in field and in glasshouse with contrasting water regimes. The yield, dry matter, and frying ability were measured in the field assays, whereas proline concentration (PrC), relative water content (RWC), and water consumption (WC) were measured in the glasshouse assays. A mixed linear model and ANOVA were performed. The best linear unbiased predictors (BLUPs) of every genotype for each measured variable were estimated. Pearson correlation coefficient (r) and principal component analysis (PCA) assessed the association among traits. The genotypes were ranked by their BLUPs values. The high diversity potato panel showed variability both in the response to water stress and within each water regime. In general, Solanum tuberosum spp. andigena genotypes were associated with the lowest PrC and higher yield, WC, and RWC. By using BLUPs, a panel of genotypes with good performance under water deficit was defined. This paper provides knowledge useful to design breeding strategies to water stress tolerance and new physiological research lines. The utilization of the elite genotypes identified in this study as progenitors constitute a starting point for breeding programs oriented to develop water‐stress‐tolerant varieties.
A Family of Water‐Immiscible, Dipolar Aprotic, Diamide Solvents from Succinic Acid
Authors: Byrne Fergal P. , Nussbaumer Clara M. , Savin Elise J. , Milescu Roxana A. , McElroy Con R. , Clark James H. , van Vugt‐Lussenburg Barbara M. A. , van der Burg Bart , Meima Marie Y. , Buist Harrie E. , Kroese E. Dinant , Hunt Andrew J. , Farmer Thomas J. 
Published: March 2020

AbstractThree dipolar aprotic solvents were designed to possess high dipolarity and low toxicity: N,N,N′,N′‐tetrabutylsuccindiamide (TBSA), N,N′‐diethyl‐N,N′‐dibutylsuccindiamide (EBSA), and N,N′‐dimethyl‐N,N′‐dibutylsuccindiamide (MBSA). They were synthesized catalytically by using a K60 silica catalyst in a solventless system. Their water immiscibility stands out as an unusual and useful property for dipolar aprotic solvents. They were tested in a model Heck reaction, metal–organic framework syntheses, and a selection of polymer solubility experiments in which their performances were found to be comparable to traditional solvents. Furthermore, MBSA was found to be suitable for the production of an industrially relevant membrane from polyethersulfone. An integrated approach involving in silico analysis based on available experimental information, prediction model outcomes and read across data, as well as a panel of in vitro reporter gene assays covering a broad range of toxicological endpoints was used to assess toxicity. These in silico and in vitro tests suggested no alarming indications of toxicity in the new solvents.
Electrochemical Evaluation of Pollutants in the Environment: Interaction Between the Metal Ions Zn(II) and Cu(II) with the Fungicide Thiram in Billings Dam
Authors: Alves Sá da Silva Vitor , da Silva Santos Aymara , Ferreira Tiago Luiz , Codognoto Lúcia , Agostini Valle Eliana Maíra 
Published: March 2020

AbstractPesticides are organic molecules used in the control of various pests in different crops. These molecules show functional groups that can interact with metal ions, forming new species with different properties. These new compounds have been attracting attention because they can become a new environmental problem. In this work the interaction of copper and zinc metal ions with Thiram pesticide was studied using electrochemical techniques. Studies in ultrapure water showed the formation of Zn−Thiram complex with reduction potential at −1.330 V; Cu−Thiram complex showed a cathodic peak at 0.020 V. Thiram causes a different effect on the two metal ions studied. It was observed that the ligand stabilizes more the Cu(II) than Zn(II). Both systems proved to be quasi‐reversible, controlled by the adsorption of the species on the electrode surface. The formation constants of the complexes were calculated to be 2.1×105 for Zn−Thiram and 1.5×1019 for Cu−Thiram. In the samples from Billings dam, the Zn‐complex showed reduction potential at −1.403 V; Cu‐complex exhibited a reduction peak at 0.012 V. Although there are interferers in river waters, the interaction of these metals with the pesticide showed high affinity, being possible to detect them in natural samples. The Cu(II) complex showed to be more stable in natural matrices when compared to the Zn(II) complex. The sensitivity for thiram electroanalytical determination decreases in the presence of Zn(II) and Cu(II).
Black raspberries suppress pancreatic cancer through modulation of NKp46+, CD8+, and CD11b+ immune cells
Authors: Pan Pan , Zhu Zheng , Oshima Kiyoko , Aldakkak Mohammed , Tsai Susan , Huang Yi‐Wen , Dong Wenjuan , Zhang Jianying , Lin Chien‐Wei , Wang Youwei , Yearsley Martha , Yu Jianhua , Wang Li‐Shu 
Published: March 2020

AbstractPancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a low survival rate (9%). Epidemiologic studies show that healthy dietary patterns enriched of fruits and vegetables lower the risk of PDAC. We previously showed that supplementing black raspberries (BRBs) to patients with colorectal cancer increased tumor‐infiltrating NK cells and their cytotoxicity. We aimed to determine whether BRBs combat PDAC by modulating cancer immunity. NOD.SCID mice lacking T and B cells were injected with human Panc‐1‐Luc cells orthotopically, and immunocompetent KrasLSL.G12D/+‐Trp53LSL.R172H/+‐Pdx‐1‐Cre mice were fed BRBs. Peripheral blood mononuclear cells (PBMCs) from PDAC patients were treated with butyrate, a microbial metabolite of BRBs. The absence of T and B cells did not dampen BRBs’ antitumor effects in the NOD.SCID mice. In the KrasLSL.G12D/+‐Trp53LSL.R172H/+‐Pdx‐1‐Cre mice, BRBs significantly prolonged survival (189 days vs. 154 days). In both models, BRBs decreased tumor‐infiltrating CD11b+ cells and the expression of IL‐1β, sEH, and Ki67. BRBs also increased tumor‐infiltrating NKp46+ cells and the expression of CD107a, a functional marker of cytolytic NK and CD8+ T cells. In KrasLSL.G12D/+‐Trp53LSL.R172H/+‐Pdx‐1‐Cre mice, tumor infiltration of CD8+ T cells was increased by BRBs. Further using the PBMCs from PDAC patients, we show that butyrate decreased the population of myeloid‐derived suppressor cells (MDSCs). Butyrate also reversed CD11b+ cell‐mediated suppression on CD8+ T cells. Interestingly, there is a negative association between MDSC changes and patients’ survival, suggesting that the more decrease in MDSC population induced by butyrate treatment, the longer the patient had survived. Our study suggests the immune‐modulating potentials of BRBs in PDAC.
Dietary polyphenols as antidiabetic agents: Advances and opportunities
Authors: Sun Chongde , Zhao Chao , Guven Esra Capanoglu , Paoli Paolo , Simal‐Gandara Jesus , Ramkumar Kunka Mohanram , Wang Shengpeng , Buleu Florina , Pah Ana , Turi Vladiana , Damian Georgiana , Dragan Simona , Tomas Merve , Khan Washim , Wang Mingfu , Delmas Dominique , Portillo Maria Puy , Dar Parsa , Chen Lei , Xiao Jianbo 
Published: March 2020

AbstractDietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on “polyphenols and diabetes” significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents. Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulin‐dependent approaches, for instance, protection of pancreatic islet β‐cell, reduction of β‐cell apoptosis, promotion of β‐cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the insulin‐independent approaches including inhibition of glucose absorption, inhibition of digestive enzymes, regulation of intestinal microbiota, modification of inflammation response, and inhibition of the formation of advanced glycation end products. Moreover, dietary polyphenols ameliorate diabetic complications, such as vascular dysfunction, nephropathy, retinopathy, neuropathy, cardiomyopathy, coronary diseases, renal failure, and so on. The structure–activity relationship of polyphenols as antidiabetic agents is still not clear. The individual flavonoid or isoflavone has no therapeutic effect on diabetic patients, although the clinical data are very limited. Resveratrol, curcumin, and anthocyanins showed antidiabetic activity in human study. How hyperglycemia influences the bioavailability and bioactivity of dietary polyphenols is not well understood. An understanding of how diabetes alters the bioavailability and bioactivity of dietary polyphenols will lead to an improvement in their benefits and clinical outcomes.
Uncertainty and the volatility forecasting power of option‐implied volatility
Authors: Jeon Byounghyun , Seo Sung Won , Kim Jun Sik 
Published: March 2020

AbstractThis study investigates the impact of uncertainty on the volatility forecasting power of option‐implied volatility. Option‐implied volatility is a powerful predictor of future volatility, particularly during periods of high uncertainty. This is consistent with option‐implied volatility being largely determined by volatility‐informed traders (rather than directional traders) when uncertainty is high. New volatility forecasting models that incorporate such interaction outperform benchmark models, both in‐ and out‐of‐sample. The new models also better predict future volatility during the 2008 global financial crisis, for which benchmark models perform poorly. The results are robust to alternative choices of benchmark models, loss functions, and estimation windows.
Responding to Covid‐19: How to Navigate a Public Health Emergency Legally and Ethically
Authors: Gostin Lawrence O. , Friedman Eric A. , Wetter Sarah A. 
Published: March 2020

AbstractFew novel or emerging infectious diseases have posed such vital ethical challenges so quickly and dramatically as the novel coronavirus SARS‐CoV‐2. The World Health Organization declared a public health emergency of international concern and recently classified Covid‐19 as a worldwide pandemic. As of this writing, the epidemic has not yet peaked in the United States, but community transmission is widespread. President Trump declared a national emergency as fifty governors declared state emergencies. In the coming weeks, hospitals will become overrun, stretched to their capacities. When the health system becomes stretched beyond capacity, how can we ethically allocate scarce health goods and services? How can we ensure that marginalized populations can access the care they need? What ethical duties do we owe to vulnerable people separated from their families and communities? And how do we ethically and legally balance public health with civil liberties?
Working Together to Lead the College to Bigger and Better Things: Exploring the Relationship Between Academic Deans and Senior Administrative Teams
Authors: Harris Nathan F. 
Published: March 2020

AbstractThis chapter examines an underexplored way in which deans enact their authority in Responsibility Center Budgeting (RCB)—mobilizing the expertise of administrators in their colleges to establish academic and budgetary priorities. The findings underscore the benefits of deans harnessing the expertise of their senior administrative teams to make sense of complex issues and problems.
Defining Mid‐Level Career Motivation and Primary Work Responsibilities in International Higher Education
Authors: Pal Patricia Ryan , McNaughtan Jon , García Hugo A. 
Published: March 2020

AbstractThis chapter uses the Job, Career, Calling conceptual framework to explore the career motivations of 119 mid‐level administrators in international higher education. Further, the primary job responsibilities of the mid‐level administrators are also examined to determine if work aligns with motivation. We find that international center directors often came to their roles through a sense of calling that was developed through prior international experiences and the desire to improve the student experience, cultural awareness, and internationalization of the institution and beyond.
“The Ones Who Move Things Along”: How Women Mid‐Level Managers Navigate Academic Landscapes
Authors: García Hugo A. , Nehls Kimberly , Florence Kimberly , Harwood Yvonne , McClain Tamara 
Published: March 2020

AbstractThis chapter uses feminist and empowerment theories as a framework to examine how women in mid‐level professional leadership perceive their level of influence and define leadership. Results indicate that empowerment behaviors are central when these women engage in opportunities to influence institutional decision‐making, in the ways they identify individuals with power and influence and use their positionality to “move things along.”
Oligometastatic head and neck cancer: Comprehensive review
Authors: Vengaloor Thomas Toms , Packianathan Satyaseelan , Bhanat Eldrin , Albert Ashley , Abraham Anu , Gordy Xiaoshan , Kanakamedala Madhava , Mehta Divyang , Vijayakumar Srinivasan 
Published: March 2020

AbstractThere are limited data available regarding the management of oligometastatic squamous cell carcinoma of the head and neck (SCCHN) patients, and no consensus guidelines are available. The objective is to review the available literature for the management of oligometastatic SCCHN. Articles were selected from English Medline literature between 1995 and 2018, searched by using the keywords: oligometastatic SCCHN/metastasectomy/stereotactic body radiation treatment (SBRT). With the available data, oligometastatic SCCHN patients appear to behave differently and tend to have a better prognosis than those with widespread metastases. Retrospective evidence suggests that the aggressive treatment of the primary disease and local treatment of the metastatic sites improves survival in oligometastatic SCCHN at diagnosis. The definitive treatment of the distant metastatic sites using metastasectomy or SBRT correlates with better survival in oligorecurrent patients. Oligometastatic SCCHN patients may have a better prognosis if treated aggressively.
The Suspended Sediment and Metals Load from the Mariana's Tailing Dam Failure to the Coastal Sea
Authors: Schettini Carlos AF , Hatje Vanessa 
Published: March 2020

Abstract
We present an assessment on the sediment flux caused by the tailing dam failure at Mariana, Minas Gerais Estate, Brazil. Field data of water level, water flow, and suspended sediment concentrations (SSCs) were obtained during the period from 21 November to 5 December 2015, when the muddy waters reached the coast. A rating curve of the coastal tidal signal was built, allowing a robust estimate of the flow at the mouth of the Doce River. Together with SSC data, early sediment delivered to the coastal sea was of 15 × 104 t, what may account for only 0.5% of the total material remobilized at the accident site. This accounted for &gt;25 000 t of Fe and between 1 and 4 t of other trace metals, such as Co, Ni, and Zn. Integr Environ Assess Manag 2020;16:661–668. © 2020 SETAC