bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Characterization of Inland Water Reservoirs Using ICESat‐2 Altimetry and Climate Reanalysis
Authors: Ryan Jonathan C. , Smith Laurence C. , Cooley Sarah W. , Pitcher Lincoln H. , Pavelsky Tamlin M. 
Published: August 2020

AbstractAccurate, transparent knowledge of global reservoir levels is a prerequisite for effective management of water resources. However, no complete database exists because gauge data are not globally available and the current generation of satellite radar altimeters resolves only the world's largest reservoirs. Here, we investigate water level changes in global reservoirs using ICESat‐2, National Aeronautics and Space Administration (NASA)'s new satellite laser altimetry mission. In just the first 12 months of the mission, we find that ICESat‐2 accurately (±14.1 cm) retrieved water level changes for 3,712 global reservoirs having surface areas ranging from <1 to >10,000 km2. From this new global data set, we identify distinct regional patterns in reservoir level change that can be attributed to both water availability and management strategy. Our findings demonstrate that ICESat‐2 will form a crucial component of any global reservoir level inventory and enable new insight into how reservoir management responds to climatic variability and increasing human demand.
Seismic Stereometry Reveals Preparatory Behavior and Source Kinematics of Intermediate‐Size Earthquakes
Authors: Mordret A. , Brenguier F. , Causse M. , Boué P. , Voisin C. , Dumont I. , Vernon F. L. , Ampuero J. P. 
Published: August 2020

AbstractAlthough moderate‐size earthquakes are poorly studied by lack of near‐fault observations, they can provide key information about larger damaging earthquakes. Here we propose a new approach, inspired by double‐difference relocation, that uses high‐coherency waveforms recorded at neighboring sensors, to study the preparation phase and dynamics of moderate‐size earthquakes. We validate this technique by analyzing the 2016, Mw5.2 Borrego Springs earthquake in Southern California and find consistent rupture velocities of 2 km/s highlighting two main rupture asperities. The analysis of the 2019, Ml5.2 Le Teil earthquake in France reveals slow nucleation at depth that migrates to the surface and propagates northward with a velocity of ∼2.8 km/s, highlighting two main rupture events also imaged by InSAR. By providing unprecedented resolution in our observation of the rupture dynamics, this approach will be useful in better understanding the preparation phase and rupture of both tectonic and induced earthquakes.
Applying Satellite Observations of Tropical Cyclone Internal Structures to Rapid Intensification Forecast With Machine Learning
Authors: Su Hui , Wu Longtao , Jiang Jonathan H. , Pai Raksha , Liu Alex , Zhai Albert J. , Tavallali Peyman , DeMaria Mark 
Published: August 2020

AbstractTropical cyclone (TC) intensity change is controlled by both environmental conditions and internal storm processes. We show that TC 24‐hr subsequent intensity change (DV24) is linearly correlated with the departures in satellite observations of inner‐core precipitation, ice water content, and outflow temperature from respective threshold values corresponding to neutral TCs of nearly constant intensity. The threshold values vary linearly with TC intensity. Using machine learning with the inner‐core precipitation and the predictors currently employed at the National Hurricane Center (NHC) for probabilistic rapid intensification (RI) forecast guidance, our model outperforms the NHC operational RI consensus in terms of the Peirce Skill Score for RI in the Atlantic basin during 2009–2014 by 37%, 12%, and 138% for DV24 ≥ 25, 30, and 35 kt, respectively. Our probability of detection is 40%, 60%, and 200% higher than the operational RI consensus, while the false alarm ratio is only 4%, 7%, and 6% higher.
Investigation of Electron Distribution Functions Associated With Whistler Waves at Dipolarization Fronts in the Earth's Magnetotail: MMS Observations
Authors: Grigorenko E. E. , Malykhin A. Y. , Shklyar D. R. , Fadanelli S. , Lavraud B. , Panov E. V. , Avanov L. , Giles B. , Le Contel O. 
Published: August 2020

AbstractUsing burst mode Magnetospheric Multiscale (MMS) observations in the plasma sheet (PS), we study the dynamics of electron anisotropy and its relation to quasi‐parallel narrowband whistler bursts in 37 dipolarization fronts (DFs) propagating in the Earth's magnetotail along with fast flows at −25 RE ≤ X ≤ −17 RE. The bursts were observed at the DFs and behind them in the dipolarizing flux bundle (DFB) region with frequencies fpeak ~ (0.1–0.6) fce ( fce is electron gyrofrequency) and durations approximately a few seconds. The majority of the whistler waves were associated with perpendicular electron temperature anisotropy TPER/TPAR > 1, and the value of this anisotropy decreased by the end of the bursts suggesting electron scattering by the waves. We found that the major contribution to the growth rate of whistler waves is made by resonant electrons with energies Wres ~ 1–5 keV and pitch angles αres ~ 40–75° and ~100–135°. In the majority of cases, the largest Wres was observed at the DF and immediately behind it, while in the DFB the Wres decreased. The sources of the majority of whistler bursts were not confined near the neutral plane but could be extended into the PS where the perpendicular anisotropy of the local electron distribution provided the positive growth rate of the whistler waves. We show that the observed whistler waves play a significant role in the dynamics of electron velocity distribution in DFs, leading to energy exchange between various parts of electron population and constraining temperature anisotropy of electron distribution.
The North Atlantic Current and its Volume and Freshwater Transports in the Subpolar North Atlantic, Time Period 1993–2016
Authors: Stendardo I. , Rhein M. , Steinfeldt R. 
Published: August 2020

AbstractThe North Atlantic Current (NAC) supplies the subpolar gyre with warm and saline water from the subtropics as part of the upper branch of the Atlantic Meridional Overturning Circulation (AMOC). In the context of climate changes, the North Atlantic Ocean is one of the key regions to investigate the variability of the overturning circulation in which salinity and freshwater variability are playing a central role. Through the gravest empirical mode (GEM) method, we reconstructed salinity and velocity fields in the same spatiotemporal resolution as the sea surface height (SSH) product. The time series of salinity, freshwater, and volume transport are characterized by strong interannual variability related to most of the recently developed subpolar gyre indices. The variability of the freshwater transport in the study area is as high or even higher than the freshwater fluxes from the Arctic Ocean and thus needs to be considered for the impact of freshwater on the subpolar North Atlantic. Our analysis also revealed that the NAC import into the subpolar gyre is not only occurring in the western Atlantic close to the western boundary current. One o the NAC branches that forms at the Mann Eddy contributes about 15% of the volume transport and 28% of the freshwater transport crossing from the western into the eastern Atlantic north of 45°N. This branch has not been subject to the strong lateral mixing with freshwater at the western boundary, and thus, the salinity of this NAC pathway is higher than the one at the western boundary.
Along‐Stream, Seasonal, and Interannual Variability of the North Icelandic Irminger Current and East Icelandic Current Around Iceland
Authors: Casanova‐Masjoan M. , Pérez‐Hernández M. D. , Pickart R. S. , Valdimarsson H. , Ólafsdóttir S. R. , Macrander A. , Grisolía‐Santos D. , Torres D. J. , Jónsson S. , Våge K. , Lin P. , Hernández‐Guerra A. 
Published: August 2020

AbstractData from repeat hydrographic surveys over the 25‐year period 1993 to 2017, together with satellite altimetry data, are used to quantify the temporal and spatial variability of the North Icelandic Irminger Current (NIIC), East Icelandic Current (EIC), and the water masses they advect around northern Iceland. We focus on the warm, salty Atlantic Water (AW) flowing northward through Denmark Strait and the cooler, fresher, denser Atlantic‐origin Overflow Water (AtOW) which has circulated cyclonically around the rim of the Nordic Seas before being advected to the Iceland slope via the EIC. The absolute geostrophic velocities reveal that approximately half of the NIIC recirculates just north of Denmark Strait, while the remaining half merges with the EIC to form a single current that extends to the northeast of Iceland, with no further loss in transport of either component. The AW percentage decreases by 75% over this distance, while the AtOW percentage is higher than that of the AW in the merged current. The NIIC and merged NIIC‐EIC are found to be baroclinically unstable, which causes the flow to become increasingly barotropic as it progresses around Iceland. A seasonal accounting of the water masses within the currents indicates that only in springtime is the NIIC dominated by AW inflow north of Denmark Strait. Overall, there is considerably more seasonal and along‐stream variability in the properties of the flow prior to the merging of the NIIC and EIC. Over the 25‐year time period, the NIIC became warmer, saltier, and increased in volume transport.
Inferring Distributed Snow Depth by Leveraging Snow Pattern Repeatability: Investigation Using 47 Lidar Observations in the Tuolumne Watershed, Sierra Nevada, California
Authors: Pflug J. M. , Lundquist J. D. 
Published: August 2020

AbstractSnow distribution is controlled by the interaction between local meteorology and static features like topography and vegetation. The resulting spatial pattern of snow in mountainous terrain is often repeatable and can be used to infer snowpack distribution at periods when observations are limited. This study uses a library of airborne lidar surveys (ALS) in California's Tuolumne watershed to analyze snow patterns at extents (1,650 km2), resolutions (25 m), and temporal scales (47 ALS observations over 7 years) unmatched by previous research. Distributed snow depth was inferred from snow depth observations covering a portion of the domain (< 4%) at a period near peak‐snowpack timing and snow distribution patterns from different years. Snow patterns from different years differed as a function of snow extents, variability, and interannual noise (r = 0.30 to 0.90). However, matching criteria like seasonal timing and snow extents were able to identify pairs of snow patterns with increased spatial agreement (median r > 0.84). Distributed snow depth inferred using a strip of observations (<4% coverage), and a well‐correlated snow pattern (r≥ 0.90) had a mean absolute error (MAE) of 0.22 m and snow volume error of −6%. Distributed snow depth inferred using patterns of reduced accuracy (r < 0.80) were often too homogeneous, thereby increasing MAE and decreasing the duration of the simulated snowmelt season. This work has applications in water management, where distributed snow depth observations in watersheds with interannual snow pattern repeatability could decrease the extent of observations necessary in future years.
Clinicopathological characterization of chronic lymphocytic leukemia with MYD88 mutations: L265P and non-L265P mutations are associated with different features
Authors: Shuai Wen , Lin Pei , Strati Paolo , Patel Keyur P. , Routbort Mark J. , Hu Shimin , Wei Peng , Khoury Joseph D. , You M. James , Loghavi Sanam , Tang Zhenya , Fang Hong , Thakral Beenu , Medeiros L. Jeffrey , Wang Wei 
Published: August 2020

AbstractMYD88 mutations in chronic lymphocytic leukemia (CLL) are not well characterized. Earlier reports yielded conflicting results in terms of clinicopathologic presentation and prognostic impact of MYD88 mutations in CLL patients. In addition, the morphological and immunophenotypic features of CLL cases carrying MYD88 mutations have not been explored. Finally, the clinical or biologic implications of the canonical L265P MYD88 mutation vs. mutations in other sites of MYD88 within the context of CLL are also unknown. In this study, a cohort of 1779 CLL patients underwent mutational analysis, and 56 (3.1%) cases were found to have MYD88 mutations, including 38 with L265P mutations (designated here as group A) and 18 with non-L265P mutations (group B). Cases with wild type MYD88 were included as controls. There was no morphological difference in cases with and without MYD88 mutations. Immunophenotypically, cases with mutated MYD88 (both groups A and B) more frequently had an atypical immunophenotype when compared to wild type cases. Group A patients were younger and were associated with variable favorable prognostic factors, including less elevated β2-microglobulin level, negative CD38 and ZAP70, higher frequency of mutated IGHV and isolated del(13q14.3), and lower frequency of del(11q22.3) and mutations of NOTCH1 and SF3B1. In contrast, group B patients were more similar to CLL patients with wild type MYD88. There was no difference in time to first treatment when comparing MYD88-mutated vs. wild type CLL patients before and after stratification according to IGHV mutation status. In summary, MYD88 mutations are uncommon in CLL and cases with L265P mutation have distinctive clinical, immunophenotypic, cytogenetic, and molecular features. There is no significant impact of MYD88 mutations on time to first treatment in CLL.
Two-color nanoscopy of organelles for extended times with HIDE probes
Authors: Chu Ling , Tyson Jonathan , Shaw Juliana E. , Rivera-Molina Felix , Koleske Anthony J. , Schepartz Alanna , Toomre Derek K. 
Published: August 2020

AbstractPerforming multi-color nanoscopy for extended times is challenging due to the rapid photobleaching rate of most fluorophores. Here we describe a new fluorophore (Yale-595) and a bio-orthogonal labeling strategy that enables two-color super-resolution (STED) and 3D confocal imaging of two organelles simultaneously for extended times using high-density environmentally sensitive (HIDE) probes. Because HIDE probes are small, cell-permeant molecules, they can visualize dual organelle dynamics in hard-to-transfect cell lines by super-resolution for over an order of magnitude longer than with tagged proteins. The extended time domain possible using these tools reveals dynamic nanoscale targeting between different organelles.
Bimodal diel pattern in peatland ecosystem respiration rebuts uniform temperature response
Authors: Järveoja Järvi , Nilsson Mats B. , Crill Patrick M. , Peichl Matthias 
Published: August 2020

AbstractAccurate projections of climate change impacts on the vast carbon stores of northern peatlands require detailed knowledge of ecosystem respiration (ER) and its heterotrophic (Rh) and autotrophic (Ra) components. Currently, however, standard flux measurement techniques, i.e. eddy covariance and manual chambers, generate empirical ER data during only night- or daytime, respectively, which are extrapolated to the daily scale based on the paradigm that assumes a uniform diel temperature response. Here, using continuous autochamber measurements, we demonstrate a distinct bimodal pattern in diel peatland ER which contrasts the unimodal pattern inherent to the classical assumption. This feature results from divergent temperature dependencies of day- and nighttime ER due to varying contributions from Rh and Ra. We further find that disregarding these bimodal dynamics causes significant bias in ER estimates across multiple temporal scales. This calls for improved process-based understanding of ER to advance our ability to simulate peatland carbon cycle-climate feedbacks.
The geography of COVID-19 spread in Italy and implications for the relaxation of confinement measures
Authors: Bertuzzo Enrico , Mari Lorenzo , Pasetto Damiano , Miccoli Stefano , Casagrandi Renato , Gatto Marino , Rinaldo Andrea 
Published: August 2020

AbstractThe pressing need to restart socioeconomic activities locked-down to control the spread of SARS-CoV-2 in Italy must be coupled with effective methodologies to selectively relax containment measures. Here we employ a spatially explicit model, properly attentive to the role of inapparent infections, capable of: estimating the expected unfolding of the outbreak under continuous lockdown (baseline trajectory); assessing deviations from the baseline, should lockdown relaxations result in increased disease transmission; calculating the isolation effort required to prevent a resurgence of the outbreak. A 40% increase in effective transmission would yield a rebound of infections. A control effort capable of isolating daily ~5.5% of the exposed and highly infectious individuals proves necessary to maintain the epidemic curve onto the decreasing baseline trajectory. We finally provide an ex-post assessment based on the epidemiological data that became available after the initial analysis and estimate the actual disease transmission that occurred after weakening the lockdown.
CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates
Authors: Shishido Hideki , Yoon Jae Seok , Yang Zhongying , Skach William R. 
Published: August 2020

AbstractProtein misfolding causes a wide spectrum of human disease, and therapies that target misfolding are transforming the clinical care of cystic fibrosis. Despite this success, however, very little is known about how disease-causing mutations affect the de novo folding landscape. Here we show that inherited, disease-causing mutations located within the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) have distinct effects on nascent polypeptides. Two of these mutations (A455E and L558S) delay compaction of the nascent NBD1 during a critical window of synthesis. The observed folding defect is highly dependent on nascent chain length as well as its attachment to the ribosome. Moreover, restoration of the NBD1 cotranslational folding defect by second site suppressor mutations also partially restores folding of full-length CFTR. These findings demonstrate that nascent folding intermediates can play an important role in disease pathogenesis and thus provide potential targets for pharmacological correction.
Quantifying net loss of global mangrove carbon stocks from 20 years of land cover change
Authors: Richards Daniel R. , Thompson Benjamin S. , Wijedasa Lahiru 
Published: August 2020

AbstractMangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments have been made into restoration programmes. Here we estimate net changes in the global mangrove carbon stock due to land cover change between 1996 and 2016, using data on mangrove deforestation and forestation, and proportional changes in carbon stock during processes of mangrove loss and gain. The global mangrove carbon stock declined by 158.4 Mt (95% CI = −156.8–525.9 Mt); a reduction of 1.8% of the stock present in 1996. Efforts to conserve and restore mangroves appear to have had some success, and - along with natural forestation - have contributed to relatively low net losses of mangrove carbon stocks over two decades.
Improved feasibility of astronaut short-radius artificial gravity through a 50-day incremental, personalized, vestibular acclimation protocol
Authors: Bretl Kathrine N. , Clark Torin K. 
Published: August 2020

AbstractThe “Coriolis” cross-coupled (CC) illusion has historically limited the tolerability of utilizing fast-spin rate, short-radius centrifugation for in-flight artificial gravity. Previous research confirms that humans acclimate to the CC illusion over 10 daily sessions, though the efficacy of additional training is unknown. We investigated human acclimation to the CC illusion over up to 50 daily sessions of personalized, incremental training. During each 25-min session, subjects spun in yaw and performed roll head tilts approximately every 30 s, reporting the presence or absence of the illusion while rating motion sickness every 5 min. Illusion intensity was modulated by altering spin rate based upon subject response, such that the administered stimulus remained near each individual’s instantaneous illusion threshold. Every subject (n = 11) continued to acclimate linearly to the CC illusion during the investigation. Subjects acclimated at an average rate of 1.17 RPM per session (95% CI: 0.63–1.71 RPM per session), with the average tolerable spin rate increasing from 1.4 to 26.2 RPM, corresponding to a reduction in required centrifuge radius from 456.6 to 1.3 m (to produce loading of 1 g at the feet). Subjects reported no more than slight motion sickness throughout their training (mean: 0.92/20, 95% CI: 0.35–1.49/20). We applied survival analysis to determine the probability of individuals reaching various spin rates over a number of training days, providing a tolerability trade parameter for centrifuge design. Results indicate that acclimation to a given, operationally relevant spin rate may be feasible for all subjects if given a sufficient training duration.
Analysis of leaf morphology, secondary metabolites and proteins related to the resistance to Tetranychus cinnabarinus in cassava (Manihot esculenta Crantz)
Authors: Yang Yanni , Luo Xinglu , Wei Wanling , Fan Zhupeng , Huang Tangwei , Pan Xiaolu 
Published: August 2020

AbstractConstitutive resistance of plant can be divided into physical and chemical barriers. Cassava (Manihot esculenta Crantz) is susceptible to mites, especially Tetranychus cinnabarinus. Although significant differences in the resistance to T. cinnabarinus are observed in different cassava cultivars, limited research has been done on the mechanism accounting for the resistance. The aim of this study was to explore the mechanism of resistance to T. cinnabarinus by comparing morphology, secondary metabolites and proteins in different cassava cultivars. The anatomical structure of leaves showed that the cassava cultivar Xinxuan 048 (XX048), which showed a stronger resistance to T. cinnabarinus in both greenhouse testing and three years field evaluation tests (2016–2018), had thicker palisade tissue, spongy tissue, lower epidermis and leaf midrib tissue compared to cultivar Guire 4 (GR4). Greenhouse evaluation demonstrated that originally these cultivars were different, leading to differences in constitutive levels of metabolites. The proteomic analysis of protected leaves in XX048 and GR4 revealed that up-regulated differentially expressed proteins (DEPs) were highly enriched in secondary metabolic pathways, especially in the biosynthesis of flavonoids. This study not only provides a comprehensive data set for overall proteomic changes of leaves in resistant and susceptible cassava, but also sheds light on the morphological characteristics of cassava-mite interaction, secondary metabolite defense responses, and molecular breeding of mite-resistant cassava for effective pest control.