bluuebunny/crossref_metadata_2025_split huggingface dataset:
Going Deep into Synaptic Vesicle Machinery Genes and Migraine Susceptibility – A Case‐Control Association Study
Authors: Quintas Marlene , Neto João Luís , Sequeiros Jorge , Sousa Alda , Pereira‐Monteiro José , Lemos Carolina , Alonso Isabel 
Published: September 2020

ObjectiveA number of observations, including among our study population, have implicated variants in the syntaxin‐1A, a component of the synaptic vesicles, in migraine susceptibility. Therefore, we hypothesize that variants in other components of the vesicle machinery are involved in migraine.BackgroundMigraine is a common and complex neurologic disorder that affects approximately 15‐18% of the general population. The exact cause of migraine is unknown; however, genetic studies have made possible substantial progress toward the identification of underlying molecular pathways. Neurotransmitters have been for long considered to have a key role in migraine pathophysiology; so we investigated common variants in genes involved in the synaptic vesicle machinery and their impact in migraine susceptibility.MethodsWe performed a case‐control study comprising 188 unrelated patients with headache and 286 healthy controls in a population from the north of Portugal. Benefiting from the presence of linkage disequilibrium, we selected and genotyped 119 tagging single‐nucleotide polymorphisms in 18 genes.ResultsWe found significant associations between single‐nucleotide variants and migraine in 7 genes, SYN1, SYN2, SNAP25, VAMP2, STXBP1, STXBP5, and UNC13A, either conferring an increased risk or protection of migraine. Due to SYN1 X‐chromosomal location, we performed the statistical analysis separated by gender and, in the female group, the C allele of rs5906435 increased the risk for migraine susceptibility (P = .021; OR = 1.69; 95% CI: 1.21‐2.34). In contrast, the TT genotype of the same variant emerged as a potential protective factor (P = .003; OR = 0.45; 95% CI: 0.27‐0.74). The SYN2 analysis supported the rs3773364's G allele (P = .014) as a risk factor for migraine, and although not statistically significant after correction, the AG genotype (P = .006; OR = 1.86; 95% CI: 1.20‐2.90) reinforced the allelic findings. Additionally, we found the SNAP25‐rs363039's CT genotype (P = .001; OR = 2.14; 95% CI: 1.36‐3.34), the STXBP5‐rs1765028's T allele (P = .041; OR = 1.46; 95% CI: 1.13‐1.90), and the UNC13B‐rs7851161's TT genotype (P = .001; OR = 2.14; 95% CI: 1.36‐3.34) as statistically significant risk factors for migraine liability. VAMP2‐rs1150's G allele revealed a risk association to migraine, not statistically significant after correction (P = .068). Additionally, we found haplotypes in SYN1, SYN2, STXBP1, and UNC13B to be associated with migraine.ConclusionsOverall, this study provides a new insight into migraine liability, identifying possible starting points for functional studies.
Intravenous Chlorpromazine as Potentially Useful Treatment for Chronic Headache Disorders
Authors: Ruiz Yanzi Maria A. , Goicochea Maria T. , Yorio Florencia , Alessandro Lucas , Farez Mauricio F. , Marrodan Mariano 
Published: September 2020

ObjectiveThe aim of this study was to describe a group of patients with chronic headache disorders (CH) and medication overuse headache (MOH) treated with intravenous chlorpromazine (IVC). We hypothesized that IVC is an effective and safe addition to well‐known treatment strategies for CH and MOH management.IntroductionUp to 4% of the general population could experience CH. Most cases occur in women, in association with MOH. To date, evidence to support different treatment strategies is lacking. Although IVC is frequently used in the emergency room (ER), documentation on its use as supportive treatment for CH and for withdrawal management of MOH is poor.MethodsA retrospective cohort of patients hospitalized to receive treatment for CH in a specialized neurological center in Argentina was analyzed.ResultsA total of 35 CH patients were included. Of the 35 patients, 33 (94%) patients also presented MOH. Patients reported only minor side effects to IVC administration (mainly drowsiness and symptomatic hypotension). Three months after inpatient treatment, the number of ER visits made by these patients decreased from an average of 2.8 in the 3 months prior to hospitalization to 0.7 after it (72%, P = .009). Headache frequency decreased in 20/34 (59%) patients during the same time period. Pain levels had dropped from a mean of 8 points at admission (in the scale of 1‐10) to 2 points at discharge. In the first 3 months of follow‐up, the average number of days per month in which patients experienced headache decreased from 28.9 to 15.4 days (53.3%, P < .0001).ConclusionIn this particular group of inpatients, there were no significant safety issues with IVC administration and the study might suggest that the efficacy of IVC as an add‐on treatment for CH and MOH.
Case of hepatitis B virus reactivation after ibrutinib therapy in which the patient remained negative for hepatitis B surface antigens throughout the clinical course
Authors: Tsuruya Kota , Anzai Kazuya , Shioyama Shunsuke , Ito Ayano , Arase Yoshitaka , Hirose Shunji , Tanaka Yasuhito , Suzuki Hidekazu , Kagawa Tatehiro 
Published: September 2020

A 71‐year‐old man was diagnosed with B‐cell chronic lymphocytic leukemia. He was negative for hepatitis B surface antigen (HBsAg), positive for antibodies against the hepatitis B surface and core, and negative for hepatitis B virus (HBV)‐DNA before starting chemotherapy. A total of 13 months after the initiation of ibrutinib (a Bruton's tyrosine kinase inhibitor), the patient's alanine aminotransferase levels suddenly increased to 427 U/L. As the level of serum HBV‐DNA increased to 5.2 logIU/mL, a diagnosis of HBV reactivation was made, whereas the patient remained negative for HBsAg. The patient's serum alanine aminotransferase levels normalized after the initiation of entecavir at a dose of 1 mg/day. However, it took >1 year to achieve an undetectable level of HBV‐DNA, even with an add‐on therapy of tenofovir disoproxil fumarate. Interestingly, the patient remained negative for HBsAg throughout the clinical course owing to triple HBsAg escape mutations: Q101K, M133L, and G145A.
Lessons learned from histological step‐sectioning of sentinel lymph nodes in penile cancer
Authors: Elversang Johanna , Grønkær Toft Birgitte , Predbjørn Krarup Kim , Jakobsen Jakob K 
Published: September 2020

AimsHistopathological examination of sentinel lymph nodes in penile cancer has varied during the first 10 years after introduction of the dynamic sentinel node (SLN) procedure in Denmark, and guidelines have been sparse. The aim of this study was to investigate the impact of rigorous step‐sectioning of sentinel lymph nodes in penile cancer and improve guidelines.Methods and resultsSeventy‐two penile squamous cell carcinoma patients undergoing SLN procedure at a single institution in 2000–2010 were included. The archived lymph node tissues already subjected to a standard pathological examination were retrieved and the initially negative lymph nodes were subjected to an extended step‐sectioning procedure. The results were compared to clinical patient outcome from a national database and subsequent pathology reports. The original histopathological examination had detected 26 SLN with metastasis, 21 macro metastases and five micro metastases. The additional step‐sectioning procedure of this study generated 4606 slides; seven SLN metastases, two macro metastases and five micro metastases, were detected. One of the macro metastases originated from a patient in which a clinical relapse had occurred in the same groin. None of the other metastases detected in this study showed ipsilateral relapse during follow‐up.ConclusionThe results underline the value of our current practice of step‐sectioning sentinel lymph nodes in penile cancer and the need for histopathological routines and guidelines. The Danish national guidelines on histopathological handling of sentinel lymph nodes have been adapted to detect any potential clinically relevant metastases.
Relationship between bioactive compounds and sensory properties of dark chocolate produced from Brazilian hybrid cocoa
Authors: das Virgens Ivia Araújo , Pires Tassia Cavalcante , de Santana Ligia Regina Radomille , Soares Sérgio Eduardo , Maciel Leonardo Fonseca , Ferreira Adriana Cristina Reis , Biasoto Aline Camarão Telles , Bispo Eliete da Silva 
Published: September 2020

SummaryThis work evaluated the influence of bioactive compounds on the sensory profile and acceptability of dark chocolate produced from Brazilian hybrid cocoa. The results showed that higher contents of catechin, epicatechin, caffeine, total phenolic compounds and flavonoids contributed to higher intensity of bitterness, cocoa flavour, acid taste, and astringency, and negatively affected the acceptance of chocolate samples from the TSH1188, PH16, and CEPEC2002 varieties. Other varieties SR162 and BN34 showed lower contents of caffeine and phenolic compounds, and higher concentration of theobromine, revealed notes of sweet/caramel and fruity flavour, presented a higher acceptance. This research showed the great potential of the ‘Catongo’ (SR162) and BN34 hybrids from southern Bahia (Brazil) for the production of fine cocoa. The chemical and sensory evaluations may be a strategic tool to help cocoa producers in deciding which genetic varieties should be marketed as fine cocoa, adding value to the product and highlighting promising cocoa varieties.
Lactose‐free skim milk and prebiotics as carrier agents of Bifidobacterium BB‐12 microencapsulation: physicochemical properties, survival during storage and in vitro gastrointestinal condition behaviour
Authors: Dantas Adriana , Verruck Silvani , de Liz Gabriela Rodrigues , Hernandez Eduard , Prudencio Elane Schwinden 
Published: September 2020

SummaryBifidobacterium BB‐12 was microencapsulated by spray drying using lactose‐free milk, lactose‐free milk and inulin, and lactose‐free milk and oligofructose, resulting in powders 1, 2 and 3, respectively. The highest encapsulation yield (88.01%) and the highest bifidobacteria viability during 120 days of storage were noted for spray‐dried powder 2. Spray‐dried powders 1 and 3 show a higher tendency to yellow colour. After being submitted to in vitro‐simulated gastrointestinal conditions, the best probiotic survival rate result was found for spray‐dried powder 3 (87.59%). Therefore, spray‐dried powders containing prebiotics were the most appropriate combinations for microencapsulation of Bifidobacterium BB‐12 and maintenance of cell viability during storage and gastrointestinal system, showing great potential to be used in lactose‐free dairy products.
Psychometric properties of the ‘Self‐Management and Transition to Adulthood with Rx = Treatment Questionnaire’ in Chinese children and young people with chronic diseases
Authors: Ma Jiali , Yu Qinglin , Ding Wenwen , Zhang Taomei , Zhang Ying 
Published: September 2020

AbstractAimsThe aims of this work were to translate, culturally adapt and evaluate the reliability and validity of the Chinese version of the Self‐Management and Transition to Adulthood with Rx = Treatment Questionnaire.BackgroundChildren and young people with chronic diseases are expected to start self‐managing their diseases and have a smooth and coordinated transition from paediatric‐ to adult‐oriented care.DesignThis study involved the cultural adaptation of a questionnaire into Chinese and examined its factor structure.MethodsThis was a multicentre cross‐sectional study of children and young people/adolescents (8–18 years) who were diagnosed with chronic diseases in China from June 2016 to December 2018. Exploratory and confirmatory factor analyses were performed to analyse the questionnaire's validity.ResultsFour major factors were identified in the Chinese version of the questionnaire, and it had a good fit to the target population. The internal reliability was good. All factors were positively and strongly correlated with the total score. The t test revealed that the Medication Management score was not significantly different between two age groups (8–11 and 12–18 years), but the scores of the other factors and overall scale were lower in the 8–11 years age group.ConclusionThe Chinese version of the questionnaire has good reliability and validity in the Chinese context.
Incidence of influenza virus infections confirmed by serology in children and adult in a suburb community, northern China, 2018‐2019 influenza season
Authors: Xu Cuiling , Liu Ling , Ren Binzhi , Dong Libo , Zou Shumei , Huang Weijuan , Wei Hejiang , Cheng Yanhui , Tang Jing , Gao Rongbao , Feng Lizhong , Zhang Ruifu , Yuan Chaopu , Wang Dayan , Chen Jing 
Published: September 2020

AbstractBackgroundIn mainland China, seasonal influenza disease burden at community level is unknown. The incidence rate of influenza virus infections in the community is difficult to determine due to the lack of well‐defined catchment populations of influenza‐like illness surveillance sentinel hospitals.ObjectivesWe established a community‐based cohort to estimate incidence of seasonal influenza infections indicated by serology and protection conferred by antibody titers against influenza infections during 2018‐2019 influenza season in northern China.MethodsWe recruited participants in November 2018 and conducted follow‐up in May 2019 with collection of sera every survey. Seasonal influenza infections were indicated by a 4‐fold or greater increase of hemagglutination inhibition (HI) antibody between paired sera.ResultsTwo hundred and three children 5‐17 years of age and 413 adults 18‐59 years of age were followed up and provided paired sera. The overall incidence of seasonal influenza infection and incidence of A(H3N2) infection in children (31% and 17%, respectively) were significantly higher than those in adults (21% and 10%, respectively). The incidences of A(H1N1)pdm09 infection in children and adults were both about 10%, while the incidences of B/Victoria and/Yamagata infection in children and adults were from 2% to 4%. HI titers of 1:40 against A(H1N1)pdm09 and A(H3N2) viruses were associated with 63% and 75% protection against infections with the two subtypes, respectively.ConclusionsIn the community, we identified considerable incidence of seasonal influenza infections. A HI titer of 1:40 could be sufficient to provide 50% protection against influenza A virus infections indicated by serology.
Optimal pricing and production decisions of fashion apparel brands in a two‐stage sales setting
Authors: Shi Baoli , Xu Qi , Sun Zhongmiao 
Published: September 2020

AbstractClothing is a typical seasonal and fashionable product; it is very easy to cause inventory backlog problems. This paper addresses the determination of pricing and production of a fashion clothing brand under both presale and regular sales stages. More specifically, we analyze the effect of the fashion degree of clothing and price on the demand. Demand during different market periods (peak sales season, low sales season, and stable market) change with time. The static pricing decision of presale price is made at the presale stage, but the regular sales price under static and dynamic pricing decisions is compared. We build both static and dynamic pricing models, with the objective of finding a pricing and production strategy that maximizes total expected profit of the clothing brand under two‐stage sale. The influences of the fashion degree attenuation factor and the initial fashion degree on the brand's optimal pricing and revenue are analyzed. We show that when the market is in the off season or the market size is stable, the brand can benefit from the dynamic pricing policy. When the market is in peak sales season, the static price is better than the dynamic price strategy. No matter how the market size changes, in the regular sales stage, the optimal price of the brand always decreases with the fashion degree attenuation factor, and increases with the fashion degree sensitivity coefficient.
Embedding carbon dots in Eu3+‐doped metal‐organic framework for label‐free ratiometric fluorescence detection of Fe3+ ions
Authors: Guo Xiaoping , Pan Qiwen , Song Xiaoqian , Guo Qianyi , Zhou Shangxiong , Qiu Jianrong , Dong Guoping 
Published: September 2020

AbstractFluorescent detection is a new spectroscopic measurement for ions sensing due to the advantages of real‐time determination with high selectivity, accuracy, and low cost. However, chemosensors based on fluorescent detection are usually determined by absolute intensity from a monochromatic emission signal, which is easy to be fluctuated by the external environment, especially for Fe3+ detection in complex fluids. Herein, we rationally design a dual‐emission Eu3+: CDs@ZIF‐8 to construct a ratiometric fluorescent sensor with self‐calibrating ability for Fe3+ determination. High efficient carbon dots (CDs) are embedded in europium ions (Eu3+)‐doped MOF by simple stirring preparation at room temperature. The label‐free ratiometric fluorescent probe (ICDs@ZIF‐8/IEu) exhibits simultaneous blue and red emission under the same excitation at 365 nm. Remarkably, Eu3+: CDs@ZIF‐8 displays the superiority of high selectivity to Fe3+, which shows ratiometric fluorescence characteristics (I0/I) in a range of 0‐6 μmol\L with a low limit of detection (LOD) of 0.897 μmol\L. Besides, the CDs‐MOF nanocomposite holds good aqueous dispersibility and low cytotoxicity, which shows great potential applications in medical aid including biological detection and clinical diagnosis.
Magnetoelectric coupling in CoFe2O4‐Pb(Zr0.2Ti0.8)O3 coaxial nanofibers
Authors: Liu Nannan , Du Pengcheng , Zhou Peng , Tanguturi Ranganadha G. , Qi Yajun , Zhang Tianjin 
Published: September 2020

AbstractIn this work, we reported the fabrication and magnetoelectric coupling properties of the multiferroic CoFe2O4‐PbZr0.2Ti0.8O3 (CFO‐PZT) coaxial nanofibers synthesized by electrospinning technique. The coaxial structure of nanofibers was demonstrated by magnetic force microscope and transmission electron microscope. The multiferroic properties of coaxial nanofibers have been revealed by magnetic hysteresis loops and piezoresponse amplitude butterfly curves and phase hysteresis loops. The as‐prepared coaxial nanofibers show an effective piezoelectric coefficient d33 of 30 pm/V and a saturated magnetization of 12 emu/g. Their magnetoelectric response has been probed by means of the localized changes in magnetization after poling the domains of the composite system. A static, large converse magnetoelectric coupling coefficient of 1.2 × 10−8 s/m was obtained in a single CFO‐PZT nanofiber.
Influence of addition of nanosize barium cerate on the microstructure and properties of top‐seeded melt growth YBCO bulk superconductors
Authors: Diko Pavel , Pagáčová Renáta , Zmorayová Katarína , Kuchárová Veronika , Vojtková Liudmila , Antal Vitaliy , Kavečanský Viktor 
Published: September 2020

AbstractBarium cerate (BaCeO3) is one of the possible additions to bulk YBa2Cu3O7 single‐grain superconductors to suppress the growth of Y2BaCuO5 (Y211) particles. This paper investigates the synthesis of barium cerate powder and its use in YBa2Cu3O7 bulk superconductors. Crystalline barium cerate was synthesized by solid‐state reaction, by co‐precipitation of oxalates and by sol‐gel method. Final calcination was held in air or in vacuum. It is shown that the most efficient in refining Y211 is nanocrystalline barium cerate prepared by sol‐gel method calcined in vacuum. The effective refinement of Y211 particles occurred over the entire interval of nanocrystalline BaCeO3 addition from 0.38 to 1.90 wt%. The optimal concentration of nanosize barium cerate was determined, microstructure and superconducting properties were characterized. The effect of Y211 content on trapped field in YBCO bulks with addition of nanocrystalline barium cerate is shown.
Mother Knows Best: Pregnancy, Applied Ethics, and Epistemically Transformative Experiences
Authors: Woollard Fiona 
Published: September 2020

AbstractL.A. Paul argues that interesting issues for rational choice theory are raised by epistemically transformative experiences: experiences which provide access to knowledge that could not be known without the experience. Consideration of the epistemic effects of pregnancy has important implications for our understanding of epistemically transformative experiences and for debate about the ethics of abortion and applied ethics more generally. Pregnancy is epistemically transformative both in Paul’s narrow sense and in a wider sense: those who have not been pregnant face significant barriers to acquiring the knowledge made accessible through pregnancy. This knowledge is crucial for engaging with the ethics of abortion. The epistemically transformativeWIDE nature of pregnancy may require us to use new methods to try to partially grasp what pregnancy is like, such as, for example, significant engagement with narrative literature. Because pregnancy is also epistemically transformative in a narrow sense, we need to work out how to engage in ethical reasoning when relevant knowledge is not fully accessible to all. This argument has implications beyond the debate about abortion. Philosophers in many areas of applied ethics will need to work out how to respond appropriately to epistemically transformative experiences.
Microbiability of meat quality and carcass composition traits in swine
Authors: Khanal Piush , Maltecca Christian , Schwab Clint , Fix Justin , Tiezzi Francesco 
Published: September 2020

AbstractThe impact of gut microbiome composition was investigated at different stages of production (weaning, Mid‐test and Off‐test) on meat quality and carcass composition traits of 1,123 three‐way crossbred pigs. Data were analysed using linear mixed models which included the fixed effects of dam line, contemporary group and gender as well as the random effects of pen, animal and microbiome information at different stages. The contribution of the microbiome to all traits was prominent although it varied over time, increasing from weaning to Off‐test for most traits. Microbiability estimates of carcass composition traits were greater than that of meat quality traits. Among all of the traits analysed, belly weight (BEL) had a higher microbiability estimate (0.29 ± 0.04). Adding microbiome information did not affect the estimates of genomic heritability of meat quality traits but affected the estimates of carcass composition traits. Fat depth had a greater decrease (10%) in genomic heritability at Off‐test. High microbial correlations were found among different traits, particularly with traits related to fat deposition with a decrease in the genomic correlation up to 20% for loin weight and BEL. This suggested that genomic correlation was partially contributed by genetic similarity of microbiome composition. The results indicated that better understanding of microbial composition could aid the improvement of complex traits, particularly the carcass composition traits in swine by inclusion of microbiome information in the genetic evaluation process.