bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cataract and glaucoma combined surgery: XEN® gel stent versus nonpenetrating deep sclerectomy, a pilot study
Authors: Theillac Vincent , Blumen-Ohana Esther , Akesbi Jad , Hamard Pascale , Sellam Alexandre , Brasnu Emmanuelle , Baudouin Christophe , Labbe Antoine , Nordmann Jean-Philippe 
Published: June 2020

Abstract
Background
To compare the efficacy of phacoemulsification (PKE) combined with nonpenetrating deep sclerectomy (NPDS) with mitomycin C (MMC) versus XEN® gel stent with MMC.

Methods
In this nonrandomized, retrospective, comparative, single-center pilot study, 105 consecutive eyes of 75 patients with uncontrolled primary open-angle glaucoma (POAG) and cataract who underwent PKE combined with either XEN implantation (n = 47) or NPDS (n = 58) between May 2013 and November 2018 were included. The primary outcome was complete success at 9 months, which was defined as intraocular pressure (IOP) ≤18, 15 or 12 mmHg without treatment; qualified success was IOP ≤18, 15 or 12 mmHg with antiglaucoma medications. Secondary outcome measures included the number of antiglaucoma medications, visual acuity (VA), and postoperative adverse events.

Results
Using the 18 mmHg threshold, complete or qualified success was achieved in 69.6 and 89.1% in the PKE + XEN group, and 63.8 and 89.7% in the PKE + NPDS group (p = .54 and p = .93), respectively, at 9 months. The mean IOP decreased from 20.8 ± 6.8 mmHg to 16.2 ± 2.8 mmHg in the PKE + XEN group (p < .001, 18.9% mean drop), and from 21.5 ± 8.9 mmHg to 14.9 ± 3.9 mmHg in the PKE + NPDS group (p < .001, 25.6% mean drop). Best-corrected VA significantly improved (p < .001) in both groups. The mean number of antiglaucoma medications was significantly reduced from 2.66 ± 1.1 to 0.49 ± 1.0 in the PKE + XEN group (p < .001) and from 2.93 ± 0.9 to 0.69 ± 1.2 in the PKE + NPDS group (p < .001).

Conclusions
The XEN stent combined with PKE seemed to be as effective and safe as PKE + NPDS at 9 months in this pilot study.
Association between combinations of nutritional status and quality of life and food purchasing motives among the elderly in South Korea
Authors: Kim Doyeon , Lim Hyunjung 
Published: June 2020

Abstract
Background
In the elderly, nutritional status and quality of life (QOL) could potentially affect food purchasing behaviors. We examined the association between combinations of nutritional status and QOL and food purchasing motives among the elderly.

Methods
A total of 143 community-dwelling elderly were recruited in Seoul, South Korea. Nutritional status and QOL were assessed and participants were divided into four groups according to those combinations. Binary logistic regression analysis was used to examine the odds of food purchasing motives according to combinations of nutritional status and QOL.

Results
As a result of comparing the scores (mean ± SD) of the overall important factors for food purchasing, health related factors such as Nutrition quality and Preventive of treatment effect were the highest score (4.4 ± 0.8), followed by Price (4.1 ± 0.9), Ease of purchase (3.8 ± 0.9), Ease of chewing (3.7 ± 0.9), and Taste (3.6 ± 0.9). Participants with a low nutritional status and low QOL had more eating-related problems (77.8%) including chewing difficulty (48.9%) and constipation (17.8%) than those with a high nutritional status and high QOL (P < 0.05). Participants who were in high nutritional status and low QOL were more likely to be motivated by Ease of chewing (OR: 6.72; 95% CI: 1.44–31.37; P < 0.05), while those who were in low nutritional status and high QOL were less motivated by Taste (OR: 0.28; 95% CI: 0.08–0.94; P < 0.05) compared to those who were in high nutritional status and high QOL.

Conclusions
There were differences in food purchasing motives such as Ease of chewing or Taste according to combinations of nutritional status and QOL. These data are important in demonstrating differing motives for food choice across nutritional status and QOL, and also provide indications of which care service and food development may be needed in promoting health for the elderly in South Korea.
3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway
Authors: Zhu Peiyao , Yu Huayun , Zhou Kun , Bai Yu , Qi Ruiqun , Zhang Shuguang 
Published: June 2020

AbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumors in the world. Aryl hydrocarbon receptor (AHR) has been reported to promote tumor metastasis and epithelial-mesenchymal transition (EMT) is a vital process of conferring cancer cells capabilities of migration and invasion. However, the mechanism by which modulation of AHR can inhibit tumor metastasis remains unknown. Thus, we aim to investigate the underlying mechanism regarding reversing EMT process of ESCC through modulation of AHR.MethodsWe used AHR selective modulator 3,3′-diindolylmethane (DIM) to treat ESCC cell lines TE1 and KYSE150 so as to examine alterations of migration and invasion by wound healing and Transwell assay. Western blotting (WB) and qPCR were performed to detect relative genes and proteins changes regarding EMT process. Cell transfection was utilized for confirming pathways involved in DIM-induced reversal of EMT and in vivo assay was conducted for verification of the underlying mechanism. Co-IP assay was conducted for detecting protein-protein interactions.ResultsAHR was overexpressed in ESCC and modulation of AHR by DIM could inhibit migration and invasion as well as downregulate mesenchymal cell markers β-Catenin, Vimentin and Slug and upregulate epithelial cell marker Claudin-1. Meanwhile, synergically overexpression of AHR, RhoA and ROCK1 correlated with poor clinical outcomes. DIM could inhibit COX2/PGE2pathway by targeting AHR, and COX2 selective inhibitor Celecoxib could suppress EMT and metastasis. Results of PGE2treatment were opposite to that of Celecoxib. Meanwhile, blockade of RhoA/ROCK1 pathway also exerted prohibitive effects on EMT and metastasis. WB results showed COX2/PGE2pathway could be regulated by RhoA/ROCK1 pathway and DIM could inhibit RhoA/ROCK1 pathway through modulation of AHR. In vivo assay verified the results in vitro. Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2pathway which was connected by NF-κB.ConclusionsIn brief, modulation of AHR by DIM can reverse EMT process and inhibit metastasis of ESCC through repressing RhoA/ROCK1-mediated COX2/PGE2pathway.
Identification of the blood perfusion rate for laser-induced thermotherapy in the liver
Authors: Andres Matthias , Blauth Sebastian , Leithäuser Christian , Siedow Norbert 
Published: June 2020

AbstractUsing PDE-constrained optimization we introduce a parameter identification approach which can identify the blood perfusion rate from MR thermometry data obtained during the treatment with laser-induced thermotherapy (LITT). The blood perfusion rate, i.e., the cooling effect induced by blood vessels, can be identified during the first stage of the treatment. This information can then be used by a simulation to monitor and predict the ongoing treatment. The approach is tested with synthetic measurements with and without artificial noise as input data.
Velocity-independent and low-complexity method for 1D DOA estimation using an arbitrary cross-linear array
Authors: Ning Gengxin , Jing Guangyu , Li Xiaopeng , Zhao Xuejin 
Published: June 2020

AbstractThis paper focuses on a low-complexity one-dimensional (1D) direction-of-arrival (DOA) algorithm with an arbitrary cross-linear array. This algorithm is highly accurate without the performance error usually caused by the uncertainty factor of the wave velocity in the underwater environment. The geometric relationship between two crossed linear arrays is employed to derive the expression of DOA estimation with the finding that this algorithm is capable of excluding the wave velocity variable in the DOA estimation expression. A method without parameter pairing is also proposed to reduce the complexity of this algorithm. Additionally, the influence of wave velocity is analyzed in terms of RMSEc and the Cramer-Rao bound (CRB) for 1D DOA with the arbitrary cross-linear array is established. The simulation results demonstrate that the proposed algorithm can achieve better performance than the traditional algorithm under the condition of an inaccurate estimate of wave velocity. Compared with the velocity-independent DOA algorithm, it exhibits the feature of low complexity.
A semi-supervised convolutional neural network based on subspace representation for image classification
Authors: Gatto Bernardo B. , Souza Lincon S. , dos Santos Eulanda M. , Fukui Kazuhiro , S. Júnior Waldir S. , dos Santos Kenny V. 
Published: June 2020

AbstractThis work presents a shallow network based on subspaces with applications in image classification. Recently, shallow networks based on PCA filter banks have been employed to solve many computer vision-related problems including texture classification, face recognition, and scene understanding. These approaches are robust, with a straightforward implementation that enables fast prototyping of practical applications. However, these architectures employ either unsupervised or supervised learning. As a result, they may not achieve highly discriminative features in more complicated computer vision problems containing variations in camera motion, object’s appearance, pose, scale, and texture, due to drawbacks related to each learning paradigm. To cope with this disadvantage, we propose a semi-supervised shallow network equipped with both unsupervised and supervised filter banks, presenting representative and discriminative abilities. Besides, the introduced architecture is flexible, performing favorably on different applications whose amount of supervised data is an issue, making it an attractive choice in practice. The proposed network is evaluated on five datasets. The results show improvement in terms of prediction rate, comparing to current shallow networks.
The impact of vitamin D food fortification and health outcomes in children: a systematic review and meta-regression
Authors: Al Khalifah Reem , Alsheikh Rawan , Alnasser Yossef , Alsheikh Rana , Alhelali Nora , Naji Ammar , Al Backer Nouf 
Published: June 2020

AbstractObjectiveVitamin D (vitD) deficiency is a global childhood health problem. Food fortification is a promising strategy to curb vitD deficiency. We aimed to assess the effectiveness of utilizing vitD fortification in staple foods to improve 25hydroxyvitamin D (25(OH)D) concentration and to reduce the prevalence of vitD deficiency among healthy children.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the use of vitD fortified food products compared to no fortification among healthy children aged 1–18 years old. We searched Medline, Embase, Global Health, and Cochrane (CENTRAL) databases from database inception until May 2019. Independently, six reviewers in pairs screened titles and abstracts, assessed the full text for eligibility, and performed data extraction and quality assessment. The primary outcome is the impact of fortification on 25(OH)D concentration. The secondary outcomes included the impact of fortification on the prevalence of vitD deficiency, school performance, cognitive function, school absences, infection rate, hospital admission length, and compliance with fortified food product consumption.ResultsWe identified 2229 articles. After assessing eligibility, 20 RCTs met the inclusion criteria. The eligible RCTs assessed the fortification of milk, cereal, juice, bread, yogurt, and cheese compared with no fortification. All RCTs, except for three, had a low risk of bias. Food fortification improved 25(OH)D concentration by a mean difference (MD) of 15.51 nmol/L (95% confidence interval (CI) 6.28, 24.74;I2= 99%), which resulted in a mean increase of 3 nmol/l for every 100 IU of vitD, when adjusted for baseline 25(OH)D concentration and country latitude. Additionally, the prevalence of vitD deficiency decreased by a risk ratio of 0.53 (95% CI 0.41, 0.69;I2= 95%), and cognitive function improved by a MD of 1.22 intelligence quotient (IQ) points (95% CI 0.65, 1.79;I2= 0%). The overall evidence quality was high.ConclusionVitD food fortification is an effective way to improve 25(OH)D concentration, prevent vitD deficiency, and improve IQ levels.Systematic review registrationPROSPEROCRD42017057631
On a unified integral operator for φ-convex functions
Authors: Chel Kwun Young , Zahra Moquddsa , Farid Ghulam , Zainab Saira , Min Kang Shin 
Published: June 2020

AbstractIntegral operators have a very vital role in diverse fields of science and engineering. In this paper, we use φ-convex functions for unified integral operators to obtain their upper bounds and upper and lower bounds for symmetric φ-convex functions in the form of a Hadamard inequality. Also, for φ-convex functions, we obtain bounds of different known fractional and conformable fractional integrals. The results of this paper are applicable to convex functions.
Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States
Authors: Urfer Silvan R. , Kaeberlein Matt , Promislow Daniel E. L. , Creevy Kate E. 
Published: June 2020

AbstractBackgroundThe privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, receives comparable medical care, and has excellent veterinary medical data available.Past studies of dog lifespan have used academic, corporate or insurance data. While independent primary care data exist for the UK, none have as of yet been published for the US. This study analyzed data from three independent primary care US veterinary hospitals and identified factors that influence lifespan and mortality in a cohort ofn = 20,970 privately owned dogs using Kaplan-Meier survival estimators and Cox Proportional Hazards modelling, including body size as a covariate.ResultsAs previously reported, body size was negatively correlated with lifespan. Gonadectomy was associated with a longer lifespan, with the effect being stronger in females than in males. This lifespan advantage was conserved in gonadectomized female dogs that lived to at least ages 5 and 8 years. We did not find significant differences in lifespan between purebred and mixed breed dogs; however, breeds with larger effective population sizes and/or lower inbreeding coefficients had median survival times 3–6 months longer than breeds with smaller effective population sizes or higher inbreeding coefficients, indicating that these measures of genetic diversity may be affecting breed lifespans. We also found that dog breeds belonging to the “Mountain” ancestral group had median survival times that were 3.5–4.6 years shorter than other purebred dog groups, which remained significant even when correcting for body size.ConclusionsOur findings show that it is possible to obtain and analyze data from independent veterinary clinics in the US, an approach that could be useful for studies of comparative epidemiology under theOne HealthandOne Welfareparadigms. We also show that the lifespan effects of gonadectomy are not identical between the sexes and should be investigated separately by sex in future analyses. More research is needed to further clarify the influence of age at gonadectomy, as well as the factors leading to the observed differences in lifespan in the “Mountain” ancestral group and in dog breeds of varying inbreeding coefficients and effective population sizes.
Multiclass EEG signal classification utilizing Rényi min-entropy-based feature selection from wavelet packet transformation
Authors: Rahman Md. Asadur , Khanam Farzana , Ahmad Mohiuddin , Uddin Mohammad Shorif 
Published: June 2020

AbstractThis paper proposes a novel feature selection method utilizing Rényi min-entropy-based algorithm for achieving a highly efficient brain–computer interface (BCI). Usually, wavelet packet transformation (WPT) is extensively used for feature extraction from electro-encephalogram (EEG) signals. For the case of multiple-class problem, classification accuracy solely depends on the effective feature selection from the WPT features. In conventional approaches, Shannon entropy and mutual information methods are often used to select the features. In this work, we have shown that our proposed Rényi min-entropy-based approach outperforms the conventional methods for multiple EEG signal classification. The dataset of BCI competition-IV (contains 4-class motor imagery EEG signal) is used for this experiment. The data are preprocessed and separated as the classes and used for the feature extraction using WPT. Then, for feature selection Shannon entropy, mutual information, and Rényi min-entropy methods are applied. With the selected features, four-class motor imagery EEG signals are classified using several machine learning algorithms. The results suggest that the proposed method is better than the conventional approaches for multiple-class BCI.
Impact of bone defect morphology on the outcome of reconstructive treatment of peri-implantitis
Authors: Aghazadeh Ahmad , Persson Rutger G. , Renvert Stefan 
Published: June 2020

AbstractObjectivesTo assess if (I) the alveolar bone defect configuration at dental implants diagnosed with peri-implantitis is related to clinical parameters at the time of surgical intervention and if (II) the outcome of surgical intervention of peri-implantitis is dependent on defect configuration at the time of treatment.Materials and methodsIn a prospective study, 45 individuals and 74 dental implants with ≥ 2 bone wall defects were treated with either an autogenous bone transplant or an exogenous bone augmentation material. Defect fill was assessed at 1 year.ResultsAt baseline, no significant study group differences were identified. Most study implants (70.7%,n= 53) had been placed in the maxilla. Few implants were placed in molar regions. The mesial and distal crestal width at surgery was greater at 4-wall defects than at 2-wall defects (p= 0.001). Probing depths were also greater at 4-wall defects than at 2-wall defects (p= 0.01). Defect fill was correlated to initial defect depth (p< 0.001). Defect fill at 4-wall defects was significant (p< 0.05).Conclusions(I) The buccal-lingual width of the alveolar bone crest was explanatory to defect configuration, (II) 4-wall defects demonstrated more defect fill, and (III) deeper defects resulted in more defect fill.
Factors associated with sugar-sweetened beverage consumption in adults with children in the home after a statewide health communications program
Authors: James Shirley A. , White Ashley H. , Paulson Sjonna Whitsitt , Beebe Laura A. 
Published: June 2020

Abstract
Background
In 2016, Oklahoma launched “Shape Your Future – Rethink Your Drink” (SYF/RYD), an obesity prevention health communication program targeting parents and caregivers of children. The aims of this study are to compare sugar-sweetened beverage (SSB) consumption before and after the program and to report factors associated with SSB consumption, knowledge, and attitudes.

Methods
This repeated cross-sectional study involved 2656 Oklahoma adults with ≥ one child under 18 years in the home. Weighted prevalence estimates were calculated and the relationship between SSB consumption and covariates of interest were examined using logistic regression techniques appropriate for survey data.

Results
Following the SYF/RYD program, SSB consumption decreased 18.6% (p = 0.0232) and heavy SSB consumption, ≥ three SSB per day, decreased 42.9% (p = 0.0083). Factors associated with SSB consumption, 1 year after the launch of SYF/RYD included high school education or less (AOR = 1.33 with 95% CI = 1.02, 1.73), fair or poor health status (AOR = 2.02 with 95% CI = 1.47, 2.78), drinking less than eight cups of water daily (AOR = 1.77 with 95% CI = 1.39, 2.25), inability to afford healthy foods (AOR = 1.33 with 95% CI = 1.06, 1.67), and self-identifying as American Indian/Alaska Native (AOR = 1.59 with 95% CI = 1.10, 2.29).

Conclusions
Health communication campaigns, such as SYF/RYD, are an evidence-based strategy for health behavior change and likely contributed to the declines observed in SSB consumption. Important differences in SSB consumption by population subgroups persist and have implications for future message development.
The “PPI Hawker”: an innovative method for patient and public involvement (PPI) in health research
Authors: Luna Puerta L. , Smith H. E. 
Published: June 2020

Abstract
Background
Patient and Public Involvement (PPI) in health research entails doing research ‘with’ the public. Successful PPI requires a diversity of patients’ perspectives and experiences. In Singapore, including the public’s voice in research is still in its infancy and different ways of involving the public have to be explored.
Our aims were to describe a PPI initiative that enables members of the public to share their ideas and opinions about health research, and to assess the feasibility, accessibility and utility of the initiative.

Methods
Building on the concept of the PPI Café used in the west we designed a “PPI Hawker” for Singapore. Here Hawker Centres rather than cafes are used frequently for eating and socialising, providing a one-stop destination for a wide section of society. The PPI facilitators approached people sitting at tables and joined them to discuss questions of relevance to a local research study. Observations and reflexive field notes were used to evaluate the “PPI Hawker’s” feasibility, acceptability and utility in the Singaporean community.

Results
In three “PPI Hawkers” we approached 96 people and 72 (75%) engaged in discussions about the design of a population-based research study. The majority (75%) of participants willingly discussed all of the questions posed to them by the researchers, indicating the feasibility of PPI. The PPI participants came from the three major ethnic groups in Singapore and appeared to be broad in age, suggesting “PPI Hawkers” are easily accessible. Both participants and researchers recognised the utility of the “PPI Hawker”, reflecting on people’s willingness to talk about the research issues, engaging in informative conversations and posing relevant questions.

Conclusion
The “PPI Hawkers” succeeded in engaging the public in conversations about a local population-based study. The public brought to the researchers’ attention a variety of previously unheard perspectives about the research. Each event fostered connectivity between professionals and the public, generating among researchers a more positive perception of the power of public involvement.
“PPI Hawkers” provide an opportunity for co-informed conduct of research studies with diverse members of the public. They create a focus within a community setting for researchers to engage with the public. The resources needed (costs and preparatory time) are relatively few. Not only do “PPI Hawkers” have potential in Singapore, but also for the rest of Asia.