bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of multidisciplinary team huddles on patient safety: a systematic review and proposed taxonomy
Authors: Franklin Brian J , Gandhi Tejal K , Bates David W , Huancahuari Nadia , Morris Charles A , Pearson Madelyn , Bass Michelle Beth , Goralnick Eric 
Published: April 2020

BackgroundDespite significant advances, patient safety remains a critical public health concern. Daily huddles—discussions to identify and respond to safety risks—have been credited with enhancing safety culture in operationally complex industries including aviation and nuclear power. More recently, huddles have been endorsed as a mechanism to improve patient safety in healthcare. This review synthesises the literature related to the impact of hospital-based safety huddles.MethodsWe conducted a systematic review of peer-reviewed literature related to scheduled, multidisciplinary, hospital-based safety huddles through December 2019. We screened for studies (1) in which huddles were the primary intervention being assessed and (2) that measured the huddle programme’s apparent impact using at least one quantitative metric.ResultsWe identified 1034 articles; 24 met our criteria for review, of which 19 reflected unit-based huddles and 5 reflected hospital-wide or multiunit huddles. Of the 24 included articles, uncontrolled pre–post comparison was the prevailing study design; we identified only two controlled studies. Among the 12 unit-based studies that provided complete measures of statistical significance for reported outcomes, 11 reported statistically significant improvement among some or all outcomes. The objectives of huddle programmes and the language used to describe them varied widely across the studies we reviewed.ConclusionWhile anecdotal accounts of successful huddle programmes abound and the evidence we reviewed appears favourable overall, high-quality peer-reviewed evidence regarding the effectiveness of hospital-based safety huddles, particularly at the hospital-wide level, is in its earliest stages. Additional rigorous research—especially focused on huddle programme design and implementation fidelity—would enhance the collective understanding of how huddles impact patient safety and other targeted outcomes. We propose a taxonomy and standardised reporting measures for future huddle-related studies to enhance comparability and evidence quality.
Ridesharing and motor vehicle crashes: a spatial ecological case-crossover study of trip-level data
Authors: Morrison Christopher N , Mehranbod Christina , Kwizera Muhire , Rundle Andrew G , Keyes Katherine M , Humphreys David K 
Published: April 2020

BackgroundRidesharing services (eg, Uber, Lyft) have facilitated over 11 billion trips worldwide since operations began in 2010, but the impacts of ridesharing on motor vehicle injury crashes are largely unknown.—MethodsThis spatial ecological case-cross over used highly spatially and temporally resolved trip-level rideshare data and incident-level injury crash data for New York City (NYC) for 2017 and 2018. The space-time units of analysis were NYC taxi zone polygons partitioned into hours. For each taxi zone-hour we calculated counts of rideshare trip origins and rideshare trip destinations. Case units were taxi zone-hours in which any motor vehicle injury crash occurred, and matched control units were the same taxi zone from 1 week before (−168 hours) and 1 week after (+168 hours) the case unit. Conditional logistic regression models estimated the odds of observing a crash (separated into all injury crashes, motorist injury crashes, pedestrian injury crashes, cyclist injury crashes) relative to rideshare trip counts. Models controlled for taxi trips and other theoretically relevant covariates (eg, precipitation, holidays).ResultsEach additional 100 rideshare trips originating within a taxi zone-hour was associated with 4.6% increased odds of observing any injury crash compared with the control taxi zone-hours (OR=1.046; 95% CI 1.032 to 1.060). Associations were detected for motorist injury and pedestrian injury crashes, but not cyclist injury crashes. Findings were substantively similar for analyses conducted using trip destinations as the exposure of interest.ConclusionsRidesharing contributes to increased injury burden due to motor vehicle crashes, particularly for motorist and pedestrian injury crashes at trip nodes.
Incidence, treatment and mortality of new-onset atrial fibrillation patients at the intensive care unit
Authors: Jacobs Maartje S , Loef Bert , Reidinga Auke C , Postma Maarten J , Van Hulst Marinus , Tieleman Robert G 
Published: April 2020

ObjectiveCritically ill patients admitted to the intensive care unit (ICU) often develop atrial fibrillation (AF), with an incidence of around 5%. Stroke prevention in AF is well described in clinical guidelines. The extent to which stroke prevention is prescribed to ICU patients with AF is unknown. We aimed to determine the incidence of new-onset AF and describe stroke prevention strategies initiated on the ICU of our teaching hospital. Also, we compared mortality in patients with new-onset AF to critically ill patients with previously diagnosed AF and patients without any AF.MethodsThis study was a retrospective cohort study including all admissions to the ICU of the Martini Hospital (Groningen, The Netherlands) in the period 2011 to 2016. Survival analyses were performed using these real-world data.ResultsIn total, 3334 patients were admitted to the ICU, of whom 213 patients (6.4%) developed new-onset AF. 583 patients (17.5%) had a previous AF diagnosis, the other patients were in sinus rhythm. In-hospital mortality and 1-year mortality after hospital discharge were significantly higher for new-onset AF patients compared with patients with no history of AF or previously diagnosed AF. At hospital discharge, only 56.3% of the new-onset AF-patients eligible for stroke prevention received an anticoagulant. Anticoagulation was not dependent on CHA2DS2-VASc score or other patient characteristics. An effect of anticoagulative status on mortality was not significant.ConclusionAF is associated with increased mortality in critically ill patients admitted to the ICU. More guidance is needed to optimise anticoagulant treatment in critically ill new-onset AF patients.
Log++ logging for a cloud-native world
Authors: Marron Mark 
Published: April 2020

Logging is a fundamental part of the software development and deployment lifecycle but logging support is often provided as an afterthought via limited library APIs or third-party modules. Given the critical nature of logging in modern cloud, mobile, and IoT development workflows, the unique needs of the APIs involved, and the opportunities for optimization using semantic knowledge, we argue logging should be included as a central part of the language and runtime designs. This paper presents a rethinking of the logger for modern cloud-native workflows.
Based on a set of design principles for modern logging we build a logging system, that supports near zero-cost for disabled log statements, low cost lazy-copying for enabled log statements, selective persistence of logging output, unified control of logging output across different libraries, and DevOps integration for use with modern cloud-based deployments. To evaluate these concepts we implemented the Log++ logger for Node.js hosted JavaScript applications.
Floralozone Ameliorated Atherosclerosis in Experimental Atherosclerotic Rats Involved with Sphingosine 1-Phosphate 1 Enhancement
Authors: Yang Yu-Ping , Zhu Mo-Li , Zhang He-Yun , Song Ping , Xu Jian , Li Peng , Yin Ya-Ling 
Published: April 2020

Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by the right carotid artery balloon injury and intraperitoneal injection of vitamin D3 in rats after 4 weeks high-fat diet. The results exhibited that Floralozone could ameliorate vascular injury and vasorelaxation of descending aortas and increase the superoxide dismutase activity and the expression of sphingosine 1-phosphate (S1P) 1 and reduce the intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, interleukin (IL)-1, IL-6 level, and the malondialdehyde activity in experimental atherosclerotic rats. However, Fingolimod, an S1P1 inhibitor, could reverse these Floralozone effects in experimental atherosclerotic rats. Our results indicated that Floralozone could inhibit the atherosclerotic plaque formation and improves arterial stenosis and reduces endothelial dysfunction in experimental atherosclerotic rats, which might be involved with S1P1 enhancement.
Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood
Authors: Peng Yue , Hai Miaomiao , Li Pengcheng , Chen Yongjie 
Published: April 2020

<b><i>Objective:</i></b> To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the ­Chinese adults. <b><i>Methods:</i></b> Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference &#x3e;90 cm in males or &#x3e;85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol &#x3c;1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study. <b><i>Results:</i></b> In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (<i>p</i> = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341–0.998 and 0.517–0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (<i>p</i> = 0.0140; OR 3.096; and OR, 95% CI 1.257–7.625). Famine exposure in early childhood was associated with the lower risk of MS (<i>p</i> = 0.0120; OR 0.633; and OR, 95% CI 0.443–0.904) in males. <b><i>Conclusions:</i></b> Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.
Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome
Authors: Pickard Sarah S. , Wong John B. , Bucholz Emily M. , Newburger Jane W. , Tworetzky Wayne , Lafranchi Terra , Benson Carol B. , Wilkins-Haug Louise E. , Porras Diego , Callahan Ryan , Friedman Kevin G. 
Published: April 2020

Background:
Fetal aortic valvuloplasty (FAV) may prevent progression of midgestation aortic stenosis to hypoplastic left heart syndrome. However, FAV has well-established risks, and its survival benefit remains unknown. Our primary aim was to determine whether FAV for midgestation aortic stenosis increases survival from fetal diagnosis to age 6 years.

Methods and Results:
We performed a retrospective analysis of 143 fetuses who underwent FAV from 2000 to 2017 and a secondary analysis of the Pediatric Heart Network Single Ventricle Reconstruction trial. Using these results, we developed a decision model to estimate probability of transplant-free survival from fetal diagnosis to age 6 years and postnatal restricted mean transplant-free survival time. FAV was technically successful in 84% of 143 fetuses with fetal demise in 8%. Biventricular circulation was achieved in 50% of 111 live-born infants with successful FAV but in only 16% of the 19 patients with unsuccessful FAV. The model projected overlapping probabilities of transplant-free survival to age 6 years at 75% (95% CI, 67%–82%) with FAV versus 72% (95% CI, 61%–82%) with expectant fetal management, resulting in a restricted mean transplant-free survival time benefit of 1.2 months. When limiting analyses to the improved FAV experience since 2009 to reflect current practice, (probability of technical success [94%], fetal demise [4%], and biventricular circulation [66%]), the model projected that FAV increased the probability of survival to age 6 years to 82% (95% CI, 73%–89%). Expectant management is favored if risk of fetal demise exceeded 12% or probability of biventricular circulation fell below 26%, but FAV remained favored over plausible recent range of technical success.

Conclusions:
Our model suggests that FAV provides a modest, medium-term survival benefit over expectant fetal management. Appropriate patient selection and low risk of fetal demise with FAV are critical factors for obtaining a survival benefit.
Comparative Study of Various Methods for Trace SF6 Measurement Using GC-µECD: Demonstration of Lab-Pressure-Based Drift Correction by Preconcentrator
Authors: Lee Jeongsoon , Kim Gahae , Lee Haeyoung , Moon Dongmin , Lee Jin-bok , Lim Jeong Sik 
Published: April 2020

AbstractThis study presents a high-precision method, using a preconcentrator–gas chromatograph with microelectron capture detector (GC-μECD), to measure SF6 at ambient levels. Carboxen 1000 was used as an adsorbent for the preconcentrator and exhibited a high adsorption efficiency for N2O and SF6 and low adsorption efficiency for O2. This enabled the selective removal of atmospheric O2 from analytes and improved repeatability of the SF6 peak that followed the O2 peak, in a separation column of activated alumina F1. In addition, the increased sensitivity resulting from preconcentrated SF6 improved the signal-to-noise ratio. This led to better analytical precision in comparison with other measurement methods including the conventional and forecut–backflush (FCBF) methods. The precision-to-drift ratios of the conventional, FCBF, and preconcentration methods were 0.11, 0.10, and 0.03, respectively. Analytical precision of the preconcentration method was 0.08% for 10 consecutive injections; this was the best among the three methods. The long-term drift of the SF6 response was inversely proportional to the laboratory pressure. Based on this finding, room pressure can be used to correct for ECD signal drift, with an uncertainty of 0.14% over a 48-h period, using the preconcentration method. Another advantage of the preconcentration method was the excellent linearity of the SF6 response to a wide range of concentrations, including its ambient concentration.
Plasma viscosity: Evaluation of a new measuring method using microfluidic chip technology (microVisc™) for clinical use and determination of a new reference range
Authors: Jørgensen Louise H , Møller Vivi S , Revsholm Jesper 
Published: April 2020

Background Plasma viscosity is an important biomarker both in diagnostics and treatment monitoring of plasma cell dyscrasias and other disorders with hyperviscosity syndrome as a clinical manifestation. Here, we investigate the performance of a new microfluidic-based viscometer for clinical use, establish a new reference range to be used with this instrument and determine the importance of sampling temperature. Methods The microVisc™ viscometer was evaluated for within-run and between-run imprecision and bias using standardized reference material (Paragon controls) and Seronorm™ control material. The reference range was established for the adult population using EDTA-plasma from 120 healthy blood donors. Sampling temperature was investigated by drawing and transporting blood at room temperature and 37°C and comparing the viscosity between the two sampling methods. Results The microfluidic-based viscometer performed well, and imprecision was comparable to ReoRox® G2 free oscillation rheometer. A new reference range for the adult Danish population was established as 1.2–1.5 mPa s at 37°C. Furthermore, sampling temperature at room temperature and 37°C was investigated, and there was no difference in results obtained. Conclusions MicroVisc™ is suitable for measuring plasma viscosity in a clinical setting and results can be evaluated using the established reference range. Blood sampling for viscosity analysis can be performed as a standard procedure at room temperature.
The Orientation and Mobility Specialist and Braille: Point–Counter Point Arguments for and Against the Need for the Knowledge of Braille
Authors: Penrod William M. , Griffin-Shirley Nora , Hollinger Kevin , Burgin Ximena , Smolka Samantha , Okungu Phoebe A. , Steinle Kyle J. , Obiero Nereah A. 
Published: April 2020

Introduction: Few academic discussions are more contentious in the field of orientation and mobility than the notion of whether or not O&M specialists need to know braille. To help answer this question, we developed a survey. Methods: An online survey instrument was distributed through O&M electronic discussion groups. The survey included a demographic section, a section concerning the use of braille for instructional purposes, questions about the importance of braille in the training and certification of O&M specialists, the level of knowledge of braille required, and whether or not respondents considered braille an essential job function. Results: Most participants ( n = 108) believed or strongly believed that braille should be a separate course in personnel preparation programs and should be required for O&M personnel preparation programs accredited by the Association for Education and Rehabilitation of the Blind and Visually Impaired (AER). Slightly less than half (42%) of respondents believed or strongly believed that braille should be required for Academy for Certification of Vision Rehabilitation and Education Professionals (ACVREP) certification in O&M ( n = 80; 22 respondents were undecided). Discussion: The field of visual impairment (i.e., blindness or low vision) needs to examine closely the amount of time, number of personnel required, and financial cost of pursuing braille as a competency for O&M specialists. Personnel costs may include additional resources to assist ACVREP in changing its requirements to include braille and the revision of the examination to reflect this new requirement, universities in hiring faculty to develop new programs of study to include coursework involving braille, and AER’s Higher Education Accreditation Commission in changing the AER University Review Accreditation Curricular Standards: Orientation and Mobility Specialists. Implications for practitioners: This study provided a snapshot of what a group ( N = 189) of vision professionals believe regarding the importance of braille in O&M—141 of that group were certified in O&M; the remainder identified themselves as having multiple certifications. Further research is needed, especially including more representation of rehabilitation professionals, to obtain more input concerning this controversial topic.
Methylphenidate treatment increases hippocampal BDNF levels but does not improve memory deficits in hypoxic-ischemic rats
Authors: Miguel Patrícia Maidana , Deniz Bruna Ferrary , Confortim Heloísa Deola , de Almeida Wellington , Bronauth Loise Peres , Vieira Milene Cardoso , Bertoldi Karine , Siqueira Ionara Rodrigues , Silveira Patrícia Pelufo , Pereira Lenir Orlandi 
Published: April 2020

Background: Methylphenidate (MPH) is a stimulant drug mainly prescribed to treat cognitive impairments in attention-deficit/hyperactivity disorder (ADHD). We demonstrated that neonatal hypoxia-ischemia (HI) induced attentional deficits in rats and MPH administration reversed these deficits. However, MPH effects on memory deficits after the HI procedure have not been evaluated yet. Aims: We aimed to analyze learning and memory performance of young hypoxic-ischemic rats after MPH administration and associate their performance with brain-derived neurotrophic factor (BDNF) levels in the prefrontal cortex and hippocampus. Methods: Male Wistar rats were divided into four groups ( n=11–13/group): control saline (CTS), control MPH (CTMPH), HI saline (HIS) and HIMPH. The HI procedure was conducted at post-natal day (PND) 7 and memory tasks between PND 30 and 45. MPH administration (2.5 mg/kg, i.p.) occurred 30 min prior to each behavioral session and daily, for 15 days, for the BDNF assay ( n=5–7/group). Results: As expected, hypoxic-ischemic animals demonstrated learning and memory deficits in the novel-object recognition (NOR) and Morris water maze (MWM) tasks. However, MPH treatment did not improve learning and memory deficits of these animals in the MWM—and even disrupted the animals’ performance in the NOR task. Increased BDNF levels were found in the hippocampus of HIMPH animals, which seem to have been insufficient to improve memory deficits observed in this group. Conclusions: The MPH treatment was not able to improve memory deficits resulting from the HI procedure considering a dose of 2.5 mg/kg. Further studies investigating different MPH doses would be necessary to determine a dose–response relationship in this model.
Automatic orbital computed tomography coordinating method and quantitative error evaluation based on signed distance field
Authors: Zhai Guangtao , Yin Ziqing , Li Lunhao , Song Xuefei , Zhou Yixiong 
Published: April 2020

Background Orbital computed tomography (CT) is commonly used for the diagnosis and digital evaluation of orbital diseases. Yet, this approach requires longer scanning time, increased radiation exposure, and, especially, difficult patient positioning that can affect judgment and data processing. According to high-quality research on orbital imaging, computer-assisted surgery, and artificial intelligent diagnostic development, the correction of a coordinate system is a necessary procedure. Nevertheless, existing manual calibration methods are challenging to reproduce and there is no objective evaluation system for errors. Purpose To establish a method for automatic calibration of orbital CT images and implementation of quantitative error evaluation. Material and Methods A standard three-dimensional (3D) orbit model was manually adjusted, and optimized orbital models were reconstructed based on the initial registration of the skull-bound directed bounding box and the registration of the mutual information method. The calibration error was calculated based on the signed distance field. Seventeen cases of orbital CT were quantitatively evaluated. Results A new method for automatic calibration and quantitative error evaluation for orbital CT was established. The calibrated model error with ±2 mm accounted for 81.61% ± 6.91% of the total models, and the error of ±1 mm accounted for 53.49% ± 7.07% of the total models. Conclusion This convenient tool for orbital CT automatic calibration may promote the related quantitative research based on orbital CT. The automated operation and small error are beneficial to the popularization and application of the tool, and the quantitative evaluation facilitates other coordinate systems.