bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renewal Reward Perspective on Linear Switching Diffusion Systems in Models of Intracellular Transport
Authors: Ciocanel Maria-Veronica , Fricks John , Kramer Peter R. , McKinley Scott A. 
Published: September 2020

AbstractIn many biological systems, the movement of individual agents is characterized having multiple qualitatively distinct behaviors that arise from a variety of biophysical states. For example, in cells the movement of vesicles, organelles, and other intracellular cargo is affected by their binding to and unbinding from cytoskeletal filaments such as microtubules through molecular motor proteins. A typical goal of theoretical or numerical analysis of models of such systems is to investigate effective transport properties and their dependence on model parameters. While the effective velocity of particles undergoing switching diffusion dynamics is often easily characterized in terms of the long-time fraction of time that particles spend in each state, the calculation of the effective diffusivity is more complicated because it cannot be expressed simply in terms of a statistical average of the particle transport state at one moment of time. However, it is common that these systems are regenerative, in the sense that they can be decomposed into independent cycles marked by returns to a base state. Using decompositions of this kind, we calculate effective transport properties by computing the moments of the dynamics within each cycle and then applying renewal reward theory. This method provides a useful alternative large-time analysis to direct homogenization for linear advection–reaction–diffusion partial differential equation models. Moreover, it applies to a general class of semi-Markov processes and certain stochastic differential equations that arise in models of intracellular transport. Applications of the proposed renewal reward framework are illustrated for several case studies such as mRNA transport in developing oocytes and processive cargo movement by teams of molecular motor proteins.
Improvement of chemical initialization in the air quality forecast system in North Macedonia, based on WRF-Chem model
Authors: Spiridonov Vlado , Ancev Nenad , Jakimovski Boro , Velinov Goran 
Published: September 2020

AbstractUrban air quality is determined by a complex interaction of factors associated with anthropogenic emissions, atmospheric circulation, and geographic factors. Most of the urban-present pollution aerosols and trace gases are toxic to human health and responsible for damage of flora, fauna, and materials. The air quality prediction system based on state-of-the-art Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) has been configured and designed for North Macedonia. An extensive set of experiments have been performed with different model settings to forecast simultaneously the weather and air quality over the country. The initial results and the finding from other similar studies suggest that chemical initialization plays a significant role in a more accurate, both qualitative and quantitative forecast and assessment of urban air pollution. The main objective of the present research is to develop and test for a novel chemical initialization input in the air quality forecast system in North Macedonia. It is performed using ensemble technique in respect to treatment of the mobile emissions data using scaling factors. The WRF-Chem prediction has shown a high sensitivity to different scaling methods. While scaling of the overall mobile annual emissions tends to produce some discrepancies regarding the PM10 concentration level (overestimation during summer and underestimation during winter), an improved approach that utilizes scaling, in a wider range, only the mobile emissions originated from household heating offers the possibility of more detailed parameter fitting. The verification results indicate that the best accuracy across all scores for the winter months was achieved when scaling up the baseline pollutant input using a higher factor, while in the other seasons, the best results were achieved when scaling down the baseline pollutant emissions by a significant factor. Taking all into account, we can conclude that the seasonal variation in the pollutant input to the atmosphere is a significant factor in simulating the pollution in this region. Therefore, these seasonal variations must be taken into account when fitting the pollutant emission input to any model.
Chronic Hepatitis B and HIV Coinfection: a Continuing Challenge in the Era of Antiretroviral Therapy
Authors: Kim H. Nina 
Published: September 2020

AbstractPurpose of ReviewThe burden of chronic hepatitis B (HBV) remains disproportionately high among people living with HIV (PLWH) despite the advent of HBV vaccination and HBV-active antiretroviral therapy (ART). This review summarizes new insights and evolving issues in HIV-HBV coinfection.Recent FindingsHBV-HIV coinfection is still a leading cause of cirrhosis, hepatocellular carcinoma (HCC), and liver-related mortality more than a decade after the approval of tenofovir. While tenofovir-based ART has been shown to improve rates of HBV virologic suppression and halt fibrosis progression, the long-term benefits on the prevention of end-stage liver disease or HCC in HIV-HBV coinfection have yet to be convincingly demonstrated in PLWH. Missed opportunities for HBV vaccination persist despite evidence of ongoing risk for HBV infection in this population.SummaryEven as we work towards HBV elimination and functional cure, ongoing efforts should focus on optimizing risk stratification as well as uptake of HBV-active antiviral therapy and HBV immunization in this priority population.
Diversity within Protestant Transnationalism: Differences in the Scope and Reach of Pentecostal/Charismatic and Evangelical Missions
Authors: Bok Jared 
Published: September 2020

Background: A growing number of studies have begun to emphasize differences between Pentecostals and Charismatics (P/Cs), on the one hand, and Evangelicals, on the other. Yet few of these studies have considered differences in transnational missions. Purpose: This study explores the extent to which P/C and Evangelical organizations vary in their transnational outreach, both in terms of what they do and where they operate. Methods: To examine these differences, I explore data on transnational American Protestant mission agencies using descriptions of trends over time and time series logistic regressions. Results: Although both P/Cs and Evangelicals tend to be concerned with otherworldly soteriological issues, I find that P/Cs are even more likely to engage in otherworldly types of activities that allow for the propagation and proliferation of the Gospel, especially with respect to evangelism and the publication and distribution of Christian literature. In addition, although both P/C and Evangelical agencies gravitate towards countries where the percentage of Protestants is low, P/C agencies are comparatively less active in countries with the lowest percentages. However, there is little evidence of differences between P/C and Evangelical agencies’ ministries when it comes to countries’ varying levels of development. Conclusions and Implications: The study concludes with several implications. First, although many differences may be more salient when distinguishing Evangelicals and P/Cs together from other Protestant traditions, there are sufficient important variations between the two former traditions to warrant treating them as analytically distinct, at least with respect to their organized transnational activism. Second, at the same time, non-findings in the study also suggest that differences between Evangelicals and P/Cs are not as pronounced at the organizational as compared to the individual level. Finally, the study reflects on the limitations of the data with recommendations for further research.
The Neglected Role of Risk Mitigation Perception in the Risk Governance of Underground Technologies—The Example of Induced Seismicity
Authors: Haemmerli Lisa , Stauffacher Michael 
Published: September 2020

AbstractSubsurface technologies, such as geothermal energy and carbon capture and storage, are options to help limit global warming. Subsurface technologies involve the risk of induced seismicity. The successful implementation of these technologies depends on the public perception of these risks. Risk governance frameworks propose assessing the level of public concern and designing adapted risk mitigation measures. We propose that concerns should not only be investigated with respect to the perceived risks but also with respect to the potential mitigation measures. We explore this by analyzing the perception of risk mitigation measures for different subsurface technologies. With an online survey (N = 808) in Switzerland we analyzed four technologies (in-between subject design) and four mitigation measures (within subject design). We found that risk mitigation measures are perceived differently, within and across technologies. Thus, public concerns about risk mitigation really matter. We suggest that future research should focus on how risk mitigation measures can be applied and communicated to realize the full potential of risk governance frameworks.
Neutral ceramidase is a marker for cognitive performance in rats and monkeys
Authors: Kalinichenko Liubov S. , Wang An-Li , Mühle Christiane , Abdel-Hafiz Laila , Gulbins Erich , Kornhuber Johannes , Oliveira André W. C. , Barros Marilia , Huston Joseph P. , Müller Christian P. 
Published: September 2020

AbstractBackgroundCeramides are lipid molecules determining cell integrity and intercellular signaling, and thus, involved in the pathogenesis of several psychiatric and neurodegenerative disorders. However, little is known about the role of particular enzymes of the ceramide metabolism in the mechanisms of normal behavioral plasticity. Here, we studied the contribution of neutral ceramidase (NC), one of the main enzymes mediating ceramide degradation, in the mechanisms of learning and memory in rats and non-human primates.MethodsNaïve Wistar rats and black tufted-ear marmosets (Callithrix penicillata) were tested in several tests for short- and long-term memory and then divided into groups with various memory performance. The activities of NC and acid ceramidase (AC) were measured in these animals. Additionally, anxiety and depression-like behavior and brain levels of monoamines were assessed in the rats.ResultsWe observed a predictive role of NC activity in the blood serum for superior performance of long-term object memory tasks in both species. A brain area analysis suggested that high NC activity in the ventral mesencephalon (VM) predicts better short-term memory performance in rats. High NC activity in the VM was also associated with worse long-term object memory, which might be mediated by an enhanced depression-like state and a monoaminergic imbalance.ConclusionsAltogether, these data suggest a role for NC in short- and long-term memory of various mammalian species. Serum activity of NC may possess a predictive role in the assessing the performance of certain types of memory.
Impact of the Major BCR-ABL1 Transcript Type on Clinical and Biological Parameters and Molecular Response in Patients With Chronic Myeloid Leukemia
Authors: Nachi Mourad , Kihel Ibtissem , Entasoltane Badra , Brahimi Mohamed , Yafour Nabil , Guella Djaoued , Abed Amine , Bekadja Mohamed A 
Published: September 2020

Aim:
In chronic myeloid leukemia (CML), the impact of MBCR-ABL1 major transcript type on disease phenotype and response to treatment still controversial to date. This work aims to study the influence of Mb3a2 and Mb2a2 transcripts on clinico-biological parameters and the molecular response in patients with chronic phase chronic myeloid leukemia (CP-CML) treated with Imatinib as frontline therapy.

Methods:
This is six years prospective study started in March 1 st, 2013. 67 patients with newly CP-CML were treated by Imatinib as frontline therapy. Clinical and biological characteristics disease were collected for all patients. Molecular typing was performed by multiplex RT-PCR and quantification of transcripts by real-time quantitative PCR (qRT-PCR). The cumulative incidence of deep molecular response (DMR) was estimated by the Kaplan-Meier method. The comparison was made using the parametric Log-Rank test. A value of P ≤ 0.05 is considered significant.

Results:
61% of patients expressed b3a2, 35.82% b2a2 and 2.98% expressed a rare transcript of type e19a2. At diagnosis, the b2a2 type had a higher level of expression than that of b3a2 (67.92 vs 53.79%; P = 0.03). This insignificant difference between the two transcript subgroups was also observed for rates below 1% at 6 months (54 vs 39; P = 0.26) and below 0.1% (54 vs 44 %; P = 0.50), (77 vs 50%; P = 0.09) and (81 vs 78 %; P = 0.52) at 12,18 and 24 months respectively. The two types of transcript had almost the same kinetics. Nevertheless, the absolute value of the BCR-ABL1/ABL ratio decrease was faster in the group of patients expressing b3a2, than in those expressing b2a2. At 18 months post IM therapy, patients with a b3a2 transcript have a trend of better MMR that those with b2a2 (77 vs 50%; P = 0.09). The DMR was not significantly different between two groups at 24 months (50 vs 32%; P = 0.20) and 36 months (75 vs 70%; P = 0.54) respectively. The cumulative probability of achieving MRD at 5 years was higher in patients with b3a2 type but not statistically significant; (85 vs. 68%; P = 0.17).

Conclusion:
Patients with b3a2 transcript may be associated with a better response to Imatinib therapy.
Toxigenic Clostridioides difficile colonization as a risk factor for development of C. difficile infection in solid-organ transplant patients
Authors: Keegan Jack , Buchan Blake W. , Ledeboer Nathan A. , Zhou Zhipeng , Hong Johnny C. , Graham Mary Beth , Munoz-Price L. Silvia 
Published: September 2020

AbstractBackground:The association between Clostridioides difficile colonization and C. difficile infection (CDI) is unknown in solid-organ transplant (SOT) patients. We examined C. difficile colonization and healthcare-associated exposures as risk factors for development of CDI in SOT patients.Methods:The retrospective study cohort included all consecutive SOT patients with at least 1 screening test between May 2017 and April 2018. CDI was defined as the presence of diarrhea (without laxatives), a positive C. difficile clinical test, and the use of C. difficile-directed antimicrobial therapy as ordered by managing clinicians. In addition to demographic variables, exposures to antimicrobials, immunosuppressants, and gastric acid suppressants were evaluated from the time of first screening test to the time of CDI, death, or final discharge.Results:Of the 348 SOT patients included in our study, 33 (9.5%) were colonized with toxigenic C. difficile. In total, 11 patients (3.2%) developed CDI. Only C. difficile colonization (odds ratio [OR], 13.52; 95% CI, 3.46–52.83; P = .0002), age (OR, 1.09; CI, 1.02–1.17; P = .0135), and hospital days (OR, 1.05; 95% CI, 1.02–1.08; P = .0017) were independently associated with CDI.Conclusions:Although CDI was more frequent in C. difficile colonized SOT patients, the overall incidence of CDI was low in this cohort.
Health Diplomacy in Pandemical Times
Authors: Fazal Tanisha M. 
Published: September 2020

AbstractOne likely effect of the COVID-19 pandemic will be an increased focus on health diplomacy, a topic that has rarely been taken up by international relations scholars. After reviewing existing literature on health diplomacy, I argue for the utility of distinguishing states’ aims from their practices of health diplomacy in advancing our understanding of when states engage in health diplomacy with a bilateral, regional, or global scope. The recent history of twenty-first century infectious disease outbreaks suggests a possible move away from health diplomacy with global participation. COVID-19 provides numerous examples, from widespread criticism of the World Health Organization to increased bilateral health aid and the creation of a regional vaccine initiative. As pandemics become more frequent, however, more localized health diplomacy is likely to be less effective, given the necessity of global mitigation and containment.
The Predictive Power of the Dividend Risk Premium
Authors: Avino Davide E. , Stancu Andrei , Simen Chardin Wese 
Published: September 2020

AbstractWe show that the dividend growth rate implied by the options market is informative about i) the expected dividend growth rate and ii) the expected dividend risk premium. We model the expected dividend risk premium and explore its implications for the predictability of dividend growth and stock market returns. Correcting for the expected dividend risk premium strengthens the evidence for the predictability of dividend growth and stock market returns both in and out of sample. Economically, a market-timing investor who accounts for the time-varying expected dividend risk premium realizes an additional utility gain of 2.02% per year.
De rebus incertis: Stephen of Liège and the Divine Office
Authors: GRIER JAMES 
Published: September 2020

ABSTRACTMost standard musicological references attribute to Bishop Stephen of Liège (†920) the composition of three Offices: for the Holy Trinity, the feast of Saint Lambert (bishop of Liège in the early eighth century to whom the city's cathedral is dedicated) and the Invention of Saint Stephen the protomartyr. From statements by Richarius, Stephen's successor at Liège, and Folcuin of Lobbes (both from the tenth century), and the eleventh-century account of Anselm of Liège, along with the evidence in Brussels, Bibliothèque royale, MS 14650-59 (a tenth-century manuscript produced at Liège during Stephen's episcopate), I conclude that Stephen of Liège did have a hand in the Offices for Saint Lambert and the Holy Trinity. Although he may have composed chants for Saint Lambert, he more likely revised existing ones for the Trinity. No tenth- or eleventh-century testimony attests the attribution of the Office for the Invention of Saint Stephen to Bishop Stephen.
Diastolic dysfunction in patients with brucellosis despite the absence of infective endocarditis
Authors: Ece İbrahim , Epçaçan Serdar , Bayhan Gülsüm İclal , Türe Mehmet 
Published: September 2020

AbstractBackground:Brucellosis is an important systemic infectious disease, especially in developing countries. Every organ and system of the human body can be affected; however, cardiovascular complications of brucellosis are rare.Aim:To assess cardiac functions in patients with acute brucellosis without overt cardiac involvement and to answer the following question: Is there any cardiac dysfunction despite the absence of endocarditis in these patients?Methods:This cross-sectional study included 67 children with brucellosis and 40 healthy children. We performed a detailed echocardiographic examination in individuals at the beginning of the treatment. Patients with infective endocarditis were excluded from the study.Results:Echocardiography revealed no difference of ejection fraction, mitral and tricuspid annular plane systolic excursion, pulsed-wave Doppler-derived early diastolic peak velocity (E)/late diastolic peak velocity (A) ratios in mitral and tricuspid valves between the two groups. The deceleration time of early mitral inflow was longer in patients with brucellosis. Early diastolic peak velocity of the mitral and tricuspid annuluses obtained by tissue Doppler imaging (Ea) was significantly lower in children with brucellosis. The peak velocity obtained by tissue Doppler imaging during late diastole (Aa), Ea and Ea/Aa ratios in the interventricular septum, left ventricle posterior wall and right ventricle free wall was lower in patients with brucellosis than in the control group. The E/Ea ratio, isovolumic relaxation time, right ventricle and left ventricle myocardial performance indices were higher in patients with brucellosis.Conclusion:Patients with acute brucellosis may have diastolic dysfunction without overt cardiac involvement and infective endocarditis.
vLex Justis: the Alternative Just Got Better
Authors: Gerami Masoud , Hawes Aidan 
Published: September 2020

AbstractMasoud Gerami, Managing Director of vLex Justis, and Aidan Hawes, Head of Commercial Development, discuss the development and launch of the new vLex Justis platform. They describe the process of making decisions behind the content and features available on the platform, and how these will be continually enhanced in the future. They also discuss the global circumstances the platform was launched within and share their goal of meeting customer needs in a future which will bring new ways of working.
Effects of herbicide management practices on the weed density and richness in dicamba-resistant cropping systems in Indiana
Authors: Hodgskiss Connor L. , Legleiter Travis R. , Young Bryan G. , Johnson William G. 
Published: September 2020

AbstractThe addition of dicamba as a weed control option in soybean [Glycine max (L.) Merr.] is a valuable tool. However, this technology must be utilized with other herbicide sites of action (SOAs) to reduce selection pressure on weed communities and ensure its prolonged usefulness. A long-term trial was conducted for 7 yr in Indiana to evaluate weed community densities and species richness with four levels of dicamba selection pressure in a corn (Zea mays L.)–soybean rotation. Monocot densities and richness increased over time in the dicamba-reliant treatment. Dicot densities in the dicamba-reliant treatment declined over time, but dicot richness increased. The soil weed seedbank was affected by the varying herbicide strategies. The dicamba-reliant strategy had greater than 43% higher total weed density than all other treatments, primarily due to having a monocot density that was at least 71% higher than the other treatments. The fully diversified strategy with eight SOAs and residual herbicides used every year had the lowest total weed species richness in the soil seedbank, which supported the in-field observations.
Sliding Crack Model for Nonlinearity and Hysteresis in the Triaxial Stress‐Strain Curve of Rock, and Application to Antigorite Deformation
Authors: David Emmanuel C. , Brantut Nicolas , Hirth Greg 
Published: September 2020

AbstractUnder triaxial deviatoric loading at stresses below failure, rocks generally exhibit nonlinearity and hysteresis in the stress‐strain curve. In 1965, Walsh first explained this behavior in terms of frictional sliding along the faces of closed microcracks. The hypothesis is that crack sliding is the dominant mode of rock inelasticity at moderate compressive stresses for certain rock types. Here we extend the model of David et al. (2012, https://doi.org/10.1016/j.ijrmms.2012.02.001) to include (i) the effect of the confining stress; (ii) multiple load‐unload cycles; (iii) calculation of the dissipated strain energy upon unload‐reload; (iv) either frictional or cohesive behavior; and (v) either aligned or randomly oriented cracks. Closed‐form expressions are obtained for the effective Young's modulus during loading, unloading, and reloading, as functions of the mineral's Young's modulus, the crack density, the crack friction coefficient and cohesion for the frictional and cohesive sliding models, respectively, and the crack orientation in the case of aligned cracks. The dissipated energy per cycle is quadratic and linear in stress for the frictional and cohesive models, respectively. Both models provide a good fit to a cyclic loading data set on polycrystalline antigorite, based on a compilation of literature and newly acquired data, at various pressures and temperatures. At high pressure, with increasing temperature, the model results reveal a decrease in friction coefficient and a transition from a frictionally to a cohesively controlled behavior. New measurements of fracture toughness and tensile strength provide quantitative support that inelastic behavior in antigorite is predominantly caused by shear crack sliding and propagation without dilatancy.