bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the effects of exercise prescribed based on health-related fitness assessment among different somatotypes
Authors: Kathirgamam Vijayakumar , Ambike Mandar , Bokan Raju , Bharambe Vaishaly , Prasad Arun 
Published: April 2020

Introduction: Human body types (somatotypes) are classified into ectomorph, mesomorph, and endomorph. The ectomorphs are physically weak and usually tall. Mesomorphs were characterized as muscular, thick skinned with good upright posture. Endomorphs characterized as fat, heavy, and usually short.
Methods: This study is an interventional study, in which a total number of 45 healthy male volunteers between the age group of 22 and 28 years were observed. Written consent was obtained from the patients after a detailed explanation of the study. Exercises were prescribed and executed based on the American College of Sports Medicine (ACSM) guidelines for exercise testing and prescription. Body composition, cardiorespiratory endurance, muscular strength, muscular endurance, and flexibility were assessed.
Results: The statistical analyses were done using the SPSS software version 16 executed at a 95% confidence interval. Mean and standard deviations were calculated by descriptive statistics. A paired t-test was done to find the effectiveness of the intervention. The level of significance in all tests was set to p < 0.05. Positive changes were observed in health-related fitness among the three groups.
Conclusion: This study reports about finding the somatotypes, and exercising based on that will provide the best results in health-related fitness components designed by the ACSM.
Probabilistic Seismic Hazard Assessment Using Legacy Data in Georgia
Authors: Onur Tuna , Gok Rengin , Godoladze Tea , Gunia Irakli , Boichenko Giorgi , Buzaladze Albert , Tumanova Nino , Dzmanashvili Manana , Sukhishvili Lasha , Javakishvili Zurab , Cowgill Eric , Bondár István , Yetirmishli Gurban 
Published: April 2020

AbstractThe Caucasus has a documented history of cataloging earthquakes stretching back to the beginning of the Christian era. Instrumental seismic observation in the Caucasus began in 1899, when the first seismograph was installed in Tbilisi, Georgia. During the Soviet era (1921–1991 in Georgia), the number of seismic stations increased in the region, providing better network coverage and a valuable dataset for seismic research. Data from many thousands of earthquakes recorded by this regional network was stored on paper in seismic bulletins. As part of the project outlined in this article, we pulled together and digitized all available paper bulletins from Georgia and neighboring countries. This allowed significant Limprovements in location accuracy and recalculation of more robust moment magnitudes for earthquakes in this region. It also paved the way for future collaboration and data exchange among the countries in the Caucasus.The resulting earthquake catalog with the new locations and magnitudes was used to conduct a probabilistic seismic hazard assessment to support a major update to the building code in Georgia to align it with the European codes. This article outlines the improvements made to the earthquake catalog in Georgia using legacy data and the new hazard assessment based on this improved dataset.
Detección precoz de lesiones intraepiteliales del cuello uterino en mujeres de Caldas-Colombia mediante la técnica de espectroscopia de impedancia eléctrica
Authors: Olarte-Echeverri Germán , Aristizábal-Botero William , Gallego-Sánchez Paula Andrea , Rojas-Díaz Jerónimo , Botero Beatriz Eugenia , Osorio Gloria Fátima 
Published: April 2020

Objetivo: evaluar la precisión diagnóstica de la espectroscopia de impedancia eléctrica para la detección de lesiones intraepiteliales del cuello uterino.Metodología: estudio de validez diagnóstica ensamblado sobre un estudio de corte transversal. Se evaluaron 285 pacientes de las cuales se seleccionaron 118 no menopáusicas que presentaron citología anormal, sin biopsias o tratamientos previos del cuello uterino. Fueron obtenidas curvas de magnitud de resistividad (Ω-m) contra frecuencia (kHz) las cuales permiten diferenciar tipos de tejidos y grados de lesión y las curvas de operación característica del receptor (COR).Resultados: de los parámetros obtenidos se encontró que la resistividad del líquido extracelular R es la que mejor discrimina entre epitelios escamosos sanos y aquellos afectados por lesiones tipo NIC 1 y NIC 2 - 3. El valor promedio de R para tejido escamoso sano fue de 24,31 Ω-m, desviación estándar 11,26, coeficiente de variación 46,3%; para tejidos con lesiones tipo NIC 1 el valor promedio fue de 9,76 Ω-m, desviación estándar 6,52, coeficiente de variación 66,8%; y para tejidos con lesiones tipo NIC 2 - 3, el valor promedio fue 6,12 Ω-m, desviación estándar 4,32, coeficiente de variación 70,6%. También fueron obtenidas curvas de magnitud de resistividad (Ω-m) contra frecuencia (kHz), las cuales permiten diferenciar tipos de tejidos y grados de lesión. La precisión de esta técnica diagnóstica fue medida utilizando curvas de operación característica del receptor (COR) con las cuales se diferencia el tejido escamoso normal y NIC 1 con sensibilidad del 79,3% y especificidad del 79,1%. Entre epitelio escamoso normal y NIC 2 - 3 con sensibilidad del 88,4% y especificidad del 87,1%. Entre NIC 1 y NIC 2 - 3 con sensibilidad y especificidad de 63,8 y 63,6% respectivamente.
Cáncer de cuello uterino: experiencia durante un período de seis años en un hospital universitario colombiano
Authors: García-Soto Germán , Pachón-Rincón Juan de Jesús , Meneses-Cubides Ronald Smith , Zuleta-Tobón John Jairo 
Published: April 2020

Objetivo: describir las características sociodemográficas y de salud de las pacientes con cáncer invasor de cuello uterino atendidas en el Hospital Universitario San Vicente de Paúl (HUSVP) de Medellín, Colombia, durante el período 1997-2002.Población: toda la cohorte de pacientes con diagnóstico confirmado de cáncer invasor de cuello uterino durante el período 1997-2002 en el HUSVP. Diseño: cohorte retrospectiva.Resultados: se atendieron 735 pacientes provenientes de 11 departamentos de Colombia, principalmente de Antioquia, Chocó y Córdoba. El 20,6% de las pacientes no tenía ningún grado de escolaridad y la mayoría era de estratos bajos. El 24,5% de las pacientes nunca se realizó citología y solo el 20% de los casos se diagnosticó en estadio I. El comportamiento clínico de la enfermedad fue similar a lo descrito en la literatura.Conclusiones: en la cohorte de pacientes estudiada se evidenció un alto nivel de pobreza, bajos niveles de escolaridad, pobre cobertura de la citología cervicovaginal y un predominio notable de los estadiostardíos de la enfermedad. Aunque el HUSVP es un centro que atiende personas de bajos recursos, este panorama debe llamar la atención acerca de una enfermedad tan catastrófica que se puede y se debe prevenir.
Matematik Öğretmeni Adaylarının Mobil Öğrenme İle Desteklenen Öğrenme Ortamına Yönelik Görüşleri
Authors: KOPARAN Timur , KALELİ YILMAZ Gül 
Published: April 2020

Bu araştırma ile mobil öğrenme ortamı ve öğretmen adaylarının mobil öğrenme
ortamı hakkındaki görüşlerinin incelenmesi amaçlanmıştır. Bu amaçla
araştırmacılar tarafından bir mobil öğrenme ortamı oluşturulmuştur. Çalışma 2017-2018
akademik yılı bahar döneminde, Batı Karadeniz Bölgesi’nde bir devlet
üniversitesindeki 44 matematik öğretmeni adayı ile yürütülmüştür. Özel durum
çalışması yönteminin kullanıldığı araştırmada, görüş formu, mobil
öğrenme tutum ölçeği, Google Classroom paylaşımları veri toplama aracı olarak
kullanılmıştır. Mobil öğrenme ortamına yönelik görüşler nitel olarak analiz
edilmiştir. Tutum ölçeğinden
elde edilen veriler, maddelerin ortalaması ile birlikte sunulmuştur. Google
Classroom ortamındaki nesneler nitelik ve paylaşım açısından
değerlendirilmiştir. Öğretmen adayları, mobil öğrenme ortamının derse yönelik
olumlu tutumun geliştirilmesine, derse karşı motivasyonunun arttırılmasına, öğrenci-öğrenci
ve öğrenci-öğretmen iletişiminin kolaylaştırılmasına olumlu katkıda
bulunduğundan, yararlı ve motive edici olduğunu belirtmişlerdir. Sonuç olarak,
öğretmen adaylarının yaratılan mobil öğrenme ortamı hakkında olumlu görüşleri
olduğu tespit edilmiştir.
Outcomes after traffic injury: mental health comorbidity and relationship with pain interference
Authors: Pozzato Ilaria , Craig Ashley , Gopinath Bamini , Kifley Annette , Tran Yvonne , Jagnoor Jagnoor , Cameron Ian 
Published: April 2020

Abstract
Background: Mental health symptoms, like depressive mood (DM) and post-traumatic stress (PTS), and pain interference (PI) with daily functioning often co-occur following traffic injury and their comorbidity can complicate recovery. This study aimed to map the course and overlapping trajectories of mental health symptoms, and associations with PI in a traffic injury population. Methods: In total, 2019 adults sustaining minor-to-moderate traffic injury were recruited within 28 days post-injury and assessed using phone interviews at 1, 6 and 12-months post-injury. Trajectories of DM, PTS and PI were established and relationships between DM, PTS and PI trajectories were explored using dual trajectory modelling. Bio-psychosocial predictors (e.g. pre-injury health, catastrophizing, acute distress, quality of life, social support) of mental health trajectories were investigated.Results: Up to five typical post-trauma trajectories were identified for DM, PTS and PI. Most people were in a resilient mental health trajectory (over 60%, DM or PTS), or in a chronic PI trajectory (almost 60%) 12 months post-injury. While recovery/resilient mental health trajectories were strongly interrelated (73.4% joint probability and >94% conditional probabilities), DM/PTS comorbidity in chronic trajectories was not straightforward, suggesting a possibly asymmetric relationship. That is, persistent DM was more likely associated with persistent PTS (90.4%), than vice versa (31.9%), with a 22.5% probability that persistent PTS was associated with none or milder depression (i.e. following a recovery/resilient DM trajectory). An asymmetrical relationship was also found between mental health and PI. The majority of those with persistent PI were likely to be in a recovery/resilient DM/PTS trajectory (almost 70%), but those in a non-resilient DM/PTS trajectory showed a high risk of persistent PI. Predictors of non-resilient mental health trajectories included poorer pre-injury health and social support, and shared factors like acute psychological distress and pain catastrophizing. Conclusions: Strong interrelations were confirmed between mental health symptoms and PI following traffic injury. However, persistent DM was more strongly linked to persistent PTS, than vice versa. Persistent PI was only linked with persistent DM/PTS in vulnerable subgroups. Early psychiatric/psychological interventions should target elevated psychological distress and negative appraisals in vulnerable individuals, to reduce long-term mental health morbidity/comorbidity and PI. Trial registration: ACTRN12613000889752.
Which interactions matter in economic evaluations? A systematic review and simulation study
Authors: Dakin Helen A , Gray Alastair 
Published: April 2020

Abstract

Background:We aimed to assess the magnitude of interactions in costs, quality-adjusted life-years (QALYs) and net benefits within a sample of published economic evaluations of factorial randomised controlled trials (RCTs), evaluate the impact that different analytical methods would have had on the results and compare the performance of different criteria for identifying which interactions should be taken into account.Methods:We conducted a systematic review of full economic evaluations conducted alongside factorial RCTs and reviewed the methods used in different studies, as well as the incidence, magnitude, statistical significance, and type of interactions observed within the trials. We developed the interaction-effect ratio as a measure of the magnitude of interactions relative to main effects. For those studies reporting sufficient data, we assessed whether changing the form of analysis to ignore or include interactions would have changed the conclusions. We evaluated how well different criteria for identifying which interactions should be taken into account in the analysis would perform in practice, using simulated data generated to match the summary statistics of the studies identified in the review.Results:Large interactions for economic endpoints occurred frequently within the 40 studies identified in the review, although interactions rarely changed the conclusions.Conclusions:Simulation work demonstrated that in analyses of factorial RCTs, taking account of all interactions or including interactions above a certain size (regardless of statistical significance) minimised the opportunity cost from adopting treatments that do not in fact have the highest true net benefit.
Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting
Authors: Arnao Valentina , Cinturino Antonio , Mastrilli Sergio , Buttà Carmelo , Maida Carlo , Tuttolomondo Antonino , Aridon Paolo , D'Amelio Marco 
Published: April 2020

Abstract
Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Methods Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311±239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson’s disease patients and healthy controls. Conclusions In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.
DiCoExpress: a tool to process multifactorial RNAseq experiments from quality controls to co-expression analysis through differential analysis based on contrasts inside GLM models.
Authors: Lambert Ilana , Roux Christine Paysant-Le , Colella Stefano , Martin-Magniette Marie-Laure 
Published: April 2020

Abstract
Background RNAseq is nowadays the method of choice for transcriptome analysis. In the last decades, a high number of statistical methods, and associated bioinformatics tools, for RNAseq analysis were developed. More recently, statistical studies realised neutral comparison studies using benchmark datasets, shedding light on the most appropriate approaches for RNAseq data analysis. Results DiCoExpress is a script-based tool implemented in R that includes methods chosen based on their performance in neutral comparisons studies. DiCoExpress uses pre-existing R packages including FactoMineR, edgeR and coseq , to perform quality control, differential, and co-expression analysis of RNAseq data. Users can perform the full analysis, providing a mapped read expression data file and a file containing the information on the experimental design. Following the quality control step, the user can move on to the differential expression analysis performed using generalized linear models thanks to the automated contrast writing function. A co-expression analysis is implemented using the coseq package. Lists of differentially expressed genes and identified co-expression clusters are automatically analyzed for enrichment of annotations provided by the user . We used DiCoExpress to analyze a publicly available RNAseq dataset on the transcriptional response of Bra ssica napus L. to silicon treatment in plant roots and mature leaves . This dataset, including two biological factors and three replicates for each condition, allowed us to demonstrate in a tutorial all the features of DiCoExpress. Conclusions DiCoExpress is an R script-based tool allowing users to perform a full RNAseq analysis from quality controls to co-expression analysis through differential analysis based on contrasts inside generalized linear models . DiCoExpress focuses on the statistical modelling of gene expression according to the experimental design and facilitates the data analysis leading the biological interpretation of the results.
Fecundity disorders in older women: declines in follicular development and endometrial receptivity
Authors: Wang Li , Lv Shulan , Mao Wenjun , Bai E , Yang Xiaofeng 
Published: April 2020

Abstract
Background : Little research is available on follicular development and endometrial receptivity in older women. This study aimed to assess follicular development and endometrial receptivity, and to evaluate ultrasonic parameters in predicting endometrial receptivity during the implantation window in older women. Methods: For this prospective case-control study, 224 older women and 215 young women were recruited. The follicular development and endometrial thickness were monitored by transvaginal ultrasound. During the implantation window, the pulsatility index (PI) and resistance index (RI) of the uterine arteries and subendometrial region, endometrial volume, vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were calculated between the two groups. The ultrasonic parameters were used to assess endometrial receptivity in older women. Results: The serum anti-Mullerian hormone (AMH) concentration and antral follicle count (AFC) were significantly lower in older women than in young women. The average diameter of the dominant follicle on days 14, 16, and 18 of the menstrual cycle were significantly smaller, and the subendometrial region RI on days 12, 14, 16, and 18 of the menstrual cycle were significantly higher in older women than in young women. The normal ovulation rate was significantly lower in older women than in young women. The subendometrial region RI was significantly higher, and the endometrial VI, FI, and VFI were significantly lower in older women compared with young women. The biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate of older women were significantly lower than in young women. The best ultrasonic parameter for predicting endometrial receptivity during the implantation window in older women was VI (AUC =0.889, sensitivity 92.6% and specificity 85.4%). Conclusions: Older women present decreased serum AMH concentrations and AFC, defined as indicators of ovarian reserve function. Older women are characterized by decreased follicular development and endometrial receptivity, which may lead to fecundity disorders.
FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1
Authors: Shi Weidong , Feng Lanyun , Dong Shu , Ning Zhouyu , Hua Yongqiang , Liu Luming , Chen Zhen , Meng Zhiqiang 
Published: April 2020

Abstract
BACKGROUND: Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, the mechanisms underlying the regulation of HSP90AA1 are poorly understood.METHODS: Transcriptome RNA-sequencing data of Liver hepatocellular carcinoma (LIHC) samples were used to detect the mRNA expression of FBXL6. Immunoprecipitation/Mass Spectrum (IP/MS) method was used to identify the interacting proteins of FBXL6. The co-immunoprecipitation assay was used to determine the interaction between FBXL6 and HSP90AA1. The in vivo ubiquitination assay was performed to determine the regulation of HSP90AA1 by FBXL6. Luciferase reporter and chromatin immunoprecipitation assays were used to determine the transcriptional regulation of FBXL6 by c-MYC. Cell counting and colony formation assays were implemented to detect the biological effects of FBXL6 on the growth of HCC cells in vitro. The effect of FBXL6 on HCC tumor growth in vivo was studied in a tumor xenograft model in mice. RESULTS: Here, we identified the orphan F-box protein FBXL6, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the ubiquitin ligase for HSP90AA1. FBXL6 promoted K63-dependent ubiquitination of HSP90AA1 to stabilize it. Through analysis of TCGA dataset, we found that FBXL6 was significantly increased in liver cancer tissues and positively correlated with c-MYC pathway. FBXL6 accumulation in liver cancers causes the stabilization and activation of c-MYC by preventing HSP90AA1 degradation. Activated c-MYC, which in turn directly bound to the promoter region of FBXL6 to induce its mRNA expression.CONCLUSION: Collectively, our data revealed an unknown FBXL6-HSP90AA1-c-MYC axis which might contribute to the oncogenesis of liver cancer, and we propose that inhibition of FBXL6 might represent an effective therapeutic strategy for liver cancer treatment.