bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Cytotoxic Properties of New Substituted Glycosides-Indole Conjugates as Apoptosis Inducers in Cancer Cells
Authors: Srour Aladdin M. , El-Bayaa Mohamed N. , Omran Mervat M. , Sharaky Marwa M. , El-Sayed Wael A. 
Published: September 2020

Background & Objective:
Glycosyl heterocycles, being as nucleoside analogs with modified glycon
and hybrid heterocycle motifs, are of considerable interest, and thus, the targeted compounds were synthesized
via a convenient and efficient approach.

Methods:
New indolyl-thiadiazolyl thioglycosides scaffolds were synthesized, starting with the reaction of
indole-3-carbaldehyde with 2-aminothiadiazole-5-thiole followed by glycosylation and deprotection. Likewise,
new molecular hybrids comprising indole, thiadiazole, triazole and glycosyl moieties were synthesized utilizing
click chemistry strategy. The cytotoxic activities of the newly synthesized compounds were studied on colon
carcinoma HCT116, breast carcinoma MCF-7, lung carcinoma A549 and hepatocellular carcinoma HepG2 cell
lines using Sulphorhodamine-B (SRB) assay.

Results:
The 1,3,4-thiadiazole thioglycoside and the 1,2,3-triazole N1-glycoside possessing xylose moiety, compounds
8 and 15 revealed the most potent bio-activity among the new chemical entities; therefore, they undertook
for further analysis of apoptosis.

Conclusion:
IC50s of Compound 8 were 38, 36, 33 and 158μg/ml, while they were 41, 44, 32 and 25μg/ml for
compound 15 on HepG2, MCF7, HCT116 and A549 cell lines, respectively; furthermore, the total apoptosis rate
(%) for control untreated cells were 9.63, 28.4, 25.4 (%), compounds 8 and 15 respectively, they produced a
significant increase in total and early apoptosis rate (%) compared to control (P=0.0001). At the same time, no
significant difference was detected in the late apoptosis rate (%), which means that both derivatives have the
potential to be developed into potent anticancer agents.
A Review on Ternary Bismuthate Nanoscale Materials
Authors: Pei Lizhai , Yu Chunhu , Xue Zeyang , Zhang Yong 
Published: September 2020

Background:
Bismuth-containing nanoscale materials exhibit great application potential in
catalysts, optical devices, electron devices, photo-electric devices and sensors owing to their good catalytic,
optical, electric, photoelectric and sensing performance. Special research interest has been devoted
to ternary bismuthate nanoscale materials due to their special layered structure, large specific surface
area, excellent optical, catalytic, electrical and electrochemical performance. Therefore, it is essential
to synthesize novel ternary bismuthate nanoscale materials for practical application.

Methods:
The article reviews the recent progress and patents on the ternary bismuthate nanoscale materials.
The recent progress and patents on the synthesis and application of the ternary bismuthate nanoscale
materials are discussed. The possible development direction of the ternary bismuthate nanoscale
materials for the synthesis and application is also analyzed.

Results:
The ternary bismuthate nanoscale materials including zinc bismuthate, copper bismuthate,
barium bismuthate, silver bismuthate, sodium bismuthate, lanthanum bismuthate nanoscale materials
can be synthesized by hydrothermal route, sol-gel route, solvothermal decomposition route and ionexchange
method. The ternary bismuthate nanoscale materials exhibit great application promising in
the fields of photocatalysts, sensors and batteries.

Conclusion:
Large-scale synthesis of ternary bismuthate nanoscale materials at low cost, doping and
combination using different nanoscale materials are important research directions for future research.
Challenges in the Correct Assessment of a Case of Aggressive Thyroid Carcinoma with Synchronous Breast Cancer: A Case Report and Review of the Literature of Essential Role of Radiopharmaceuticals
Authors: Piciu Andra , Mester Alexandru , Rusu George , Piciu Doina 
Published: September 2020

Conclusion:
Thyroid carcinoma represents a complex pathology that can still be considered a medical
challenge, despite having a better prognosis and life expectancy than most other neoplasms; also
the scenario of multiple malignancies involving thyroid cancer is nowadays a common reality.

Materials and Methods:
We reviewed the literature regarding the aggressive presentation of
synchronous thyroid and breast cancer. In the current paper, we report the case of a 59 years-old
woman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting
a natural history of both aggressive synchronous tumors. At the moment of hospitalization, the
diagnosis was breast carcinoma with multiple secondary lesions, suggestive of lung and bone metastases,
and nodular goiter.

Results:
Searching the literature in PUBMED with the terms “thyroid
carcinoma and synchronous breast carcinoma, we found 86 studies; introducing the term “aggressive,”
the result included 4 studies, among which, none showed to be relevant to the terms aggressive
and synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing
the term aggressive, the number of papers was 8, none including the literature on synchronous
aggressive metastatic thyroid and breast carcinoma. A majority of imaging diagnostic tools
were used in this particular medical case in order to ensure the best potential outcome. The final diagnosis
was papillary thyroid carcinoma with lung and unusual multiple bone metastases and
synchronous invasive ductal breast carcinoma with subcutaneous metastases.

Conclusion:
The case illustrates the challenges in the correct assessment of oncologic patients, despite the advances in
medical imaging and technologies and underlines the essential role of nuclear medicine procedures
in the diagnostic and therapy protocols.
Inflammaging of Female Reproductive System: A Molecular Landscape
Authors: Rodichkina Valeriia , Kvetnoy Igor , Polyakova Victoria , Arutjunyan Alexander , Nasyrov Ruslan , Ivanov Dmitry 
Published: September 2020

:
Aging is a complex biological process, a major aspect of which is the accumulation of
somatic changes throughout life. Cellular senescence is a condition in which cells undergo an irreversible
cell cycle arrest in response to various cellular stresses. Once the cells begin to senesce,
they become more resistant to any mutagens, including oncogenic factors. Inflammaging (inflammatory
aging) is an age-related, chronic, and systemic inflammatory condition realized by cells
with the Senescence-Associated Secretory Phenotype (SASP). These recently recognized senescent
phenotypes associated with aging have been reported to promote better wound healing, embryonic
development, as well as stimulation and extension of the tumor process. It is assumed that cellular
senescence contributes to the age-related decline of reproductive function due to the association of
senescent cells with aging and age-related diseases. Thus, SASPs have both positive and negative
effects, depending on the biological context. SASP cell accumulation in tissues contributes to an
age-related functional decline of the tissue and organ state. In this review, the term “cellular senescence”
is used to refer to the processes of cells irreversible growth inhibition during their viable
state, while the term “aging” is used to indicate the deterioration of tissues due to loss of function.
Late reproductive age is associated with infertility and possible complications of the onset and
maintenance of pregnancy. Senescent cells express pro-inflammatory cytokines, growth factors,
and matrix metalloproteinases and some other molecules collectively called the Senescence-Associated
Secretory Phenotype (SASP).
Dual Modulators of Selected Plant Secondary Metabolites Targeting COVID-19 Main Protease and Interleukin-2: An In-Silico Approach based Novel Hypothesis
Authors: Prabha Thangavelu , Kapoor Vijay K. , Selvamani Palanisamy , Latha Subbiah , Sivakumar Thangavel , Jubie Selvaraj 
Published: September 2020

Background:
Owing to the recent scenario on this ongoing Coronavirus pandemic outbreak
around the world, the present study has been undertaken.

Aim:
In this study, we adopted two strategies, i.e., via computational method, a search for the novel
plant secondary metabolites from the Indian Traditional Medicine to target and combat the enduring
novel 2019 CoVs main protease that causes pneumonia, followed by the effect of these selected secondary
metabolites on the host’s immune system for their immunomodulatory potential on Interleukin-2.

Methods:
A detailed literature review has been done to identify the assorted plant secondary metabolites
from the natural sources, which have been extensively used traditionally for their immunomodulatory
potential. Next, the resulting compounds have processed for the molecular docking study to predict
whether the compounds have the potency to fight against 2019- CoVs protein or it could have the tendency
to battle the cytokines, which are responsible for the immune response of the host, thereby preventing
the CoVs caused infection in humans. Furthermore, to explore molecular mechanics, the insilico
docking study with COVID-19 Mpro and Interleukin-2 has been performed.

Results & Discussion:
Among the six secondary metabolites selected, five compounds showed its possible
promising potency with COVID-19 and IL-2 proteins, which are compared with the standard drug
Remdesivir, one of the anti-viral drugs for treating and managing the present coronavirus condition and
an IL-2 inhibitor, which is the native IL-2 ligand protein (i.e., from PDB Id- 1PW6) itself. Besides,
based on the docking scores, the Curcumin (from Curcuma longa) showed the highest score towards
these two targets taken for this study. The identified compounds have a promising binding affinity with
the Mpro receptors, in the narrow range of binding energy for the protein PDB Id: 6LU7 and the score
range between -10.9102 to -19.8790 kcal/mol: when compared to the standard -21.8600 kcal/mol.
Whereas, the binding affinity with the Interleukin -2 receptor, for the protein PDB Id: 1PW6 the range
between -11.3899 to -17.1366 kcal/mol: when compared to that of standard -16.9554 kcal/mol.

Conclusion:
Our result findings demonstrate that the integrated Indian traditional herbal treatment
might be hopefully used for the viral respiratory infection due to either it may have acted directly on the
viral protein or through regulating the immune response, which could lead to the rapid drug discovery of
the drug leads with clinical potency towards the novel infectious disease, where there is no drug or vaccines
are available.
Efficacy of Sulfuryl Fluoride as a Fumigant against Aspergillus niger on Corn Seeds
Authors: Panjaitan Leny , Salbiah Salbiah , Hadi Ranta , Abdurakhman Abdurakhman , Ahad Mustopha 
Published: September 2020

The importation of corn seeds may inadvertently introduce seed-borne fungi like Aspergillus niger. One potential method to control this pathogen was fumigation with sulfuryl fluoride. The objectives of this applied research were to obtain effective concentration and exposure time of sulfuryl flouride as a fumigant to control seedborne fungi and to its physiological impact on corn seeds. Aspergillus niger was isolated from corn seed samples, grew it in potato dextrose agar, and used it for in vitro studies. Parameters observed were isolates’ growth inhibition. In vivo studies were conducted using corn seed samples infected by Aspergillus niger. Sulfuryl fluoride was applied at the concentration of 30, 40, 50, and 60 g/m3 and 24, 48, 72, and 96 hour of exposure time. Results showed that sulfuryl fluoride concentration of 40 g/m3 for 48 hours at 26-32°C is the only effective concentration against A. niger in vitro but all of the treatment did not significantly affect A. niger in vivo. Concentration of 30, 40, 50, 60 g/m3 for 24 hours does not affect the quality of the seed.
Survey of Rice Pests, Diseases and Natural Enemies on “Upsus” Program in Karawang District, West Java Province
Authors: Effendi Kurniawan , Munif Abdul , Winasa I Wayan 
Published: September 2020

"Upsus" (Special Efforts) Program is a program to increase crop production and productivity to support the acceleration of food self-sufficiency held by the government. The targets are to increase the planting index (IP) by 0.5 and productivity by 0.3 ton/ha/Harvested Dry Grain (HDG). Increased productivity has not been reached optimally. This research aimed to determine the number/types of the dominant pests and natural enemies, and pests and diseases attack rates in the wetland rice plantation "Upsus" Program in Karawang District. Direct observation was carried out on four stages of plant development, in the nursery stage (10–14 days after sowing) 200–300 m², seedlings stage (10–20 days after planting), vegetative stage (5–6 weeks after planting), and reproductive stage (1–2 weeks after flowering) respectively within an area of 2000 m². Twenty samples were observed in the nursery stage and 50 samples in the following stages. The dominant pests and diseases found were Nilaparvata lugens, Leptocarisa oratorius, Schirpophaga incertulas, Cnaphalocrocis medinalis, Scotinophara coarctata, Mythimna separata, bacterial leaf blight (Xanthomonas. oryzae pv. oryzae), blast (Pyricularia grisea) and narrow brown spot (Cercospora oryzae). The recorded dominant natural enemies were Cyrtorhinus sp., Paederus sp., Tetragnatha sp., and Pardosa pseudoannulata. S. incertulas showed the highest attack intensity and the highest disease severity was found in bacterial leaf blight. The largest population of dominant pests and natural enemies was found in the generative stage. The high application of pesticides affected the population of pests, natural enemies, and the level of pest and disease attacks.
Simulasi Docking Molekuler Senyawa Potensial Tanaman Justicia Gendarussa Burm.f. Sebagai Antidiabetes
Authors: Adelina Rosa 
Published: September 2020

Abstract
Indonesia has various natural compounds that are potential as antidiabetics but the mechanism of action was not yet known in detail, one of them is Justicia gendarussa. Justicia gendarussa is known as Gandarusa contains kaempferol and naringenin. In this study, the two compounds were simulated with glucokinase enzyme using a glibenclamide as a standard reference drug to determine their potential action as an antidiabetic. The research method was carried out using molecular docking computation simulation (in silico). The results showed the binding energy scores of glibenclamide, naringenin, and kaempferol to glucokinase enzymes are -22.0917; -22,1866; and -22,6328 kcal/mol, respectively. The hydrogen bonding plays in binding the enzyme. These results showed the binding energy score was not different significantly. Thus, naringenin and kaempferol had the same antidiabetic potential as glibenclamide.
Keywords: Justicia gendarussa, antidiabetes, molecular docking, naringenin, kaempferol
Abstrak
Berbagai senyawa alam Indonesia berpotensi sebagai antidiabetes namun belum diketahui mekanisme aksinya secara rinci, salah satu contohnya Justicia gendarussa Burm.f.. Tanaman Justicia gendarussa yang dikenal baik dengan nama Gandarusa, mengandung kaempferol dan naringenin. Pada penelitian ini, kedua senyawa disimulasikan terhadap enzim glukokinase menggunakan senyawa pembanding glibenklamid yang merupakan obat referensi untuk mengetahui potensinya sebagai antidiabetes. Metode penelitian dilakukan menggunakan simulasi komputasi docking molekuler (in silico). Hasil docking molekuler menunjukkan skor energi ikatan glibenklamid, naringenin dan kaempferol terhadap enzim glukokinase masing-masing sebesar -22,0917; -22,1866 ; dan -22,6328 kkal/mol. Ikatan yang berperan adalah ikatan hydrogen. Hasil penelitian menunjukkan nilai skor energi ikatan yang tidak berbeda signifikan. Dengan demikian naringenin dan kaempferol memiliki potensi sebagai antidiabetes yang sama dengan glibenklamid.
Kata kunci: Justicia gendarussa, antidiabetes, docking molekuler, naringenin, kaempfero
KLENTENG KWANG SING BIO DI KELURAHAN KARANGSARI, KECAMATAN TUBAN, KABUPATEN TUBAN, JAWA TIMUR (SEJARAH, STRUKTUR DAN FUNGSI SERTA POTENSINYA SEBAGAI SUMBER BELAJAR SEJARAH DI SMA)
Authors: Husna Thobi’atul 
Published: September 2020

Tujuan penelitian ini adalah untuk mengetahui (1)Sejarah berdirinya Klenteng Kwang Sing BioTuban (2) stuktur dan fungsi dari bangunan Klenteng Kwang Sing Bio,(3)aspek-aspek yang dapat digunakan dari bangunan Klenteng Kwang Sing Bio sebagai sumber belajar sejarah di SMA. Jenis penelitian ini menggunakan pendekatan kualitatif, dengan tahap-tahap: (1)lokasi penelitian di Klenteng Kwang Sing Bio di kelurahan karangsari, kecamatan Tuban, kabupaten Tuban,Jawa Timur (2)Metode penentuan informan menggunakan Purposive Sampling, dikembangkan dengan Snow Ball (3)Metode pengumpulan datamelalui observasi, wawancara, dan studi pustaka (4)validasi data menggunkan trianggulasi data dan trianggulasi metode),(5)analisis data menggunakan analisis interaksi. Hasil penelitian menunjukkan bahwa,(1)sejarah pendirian Klenteng kwang sing bio ini dimulai dari periode awal pada tahun 1742-1970 dan mengalami pengembangan bangunan dari periode tahun 1970 hingga-sekarang(2)Struktur klenteng Kwang Sing Bioterdiri dari beberapa bagian, yaitu bangunan utama, bangunan tengah, bangunan barat, dan bangunan belakang,klenteng Kwang Sing Bio memiiliki 5 fungsi yaitu fungsi religi, sosia, ekonomi, destinasi wisata dan pendidikan(3)Klenteng Kwang Sing Bio berpotensi sebagai sumber belajar sejarah di SMA di kelas X dan XI berdasarkan kurikulum 2013, adapun aspek-aspek yang dapat digunakan yaitu: aspek sejarah, aspek bangunan, dan aspek kerukunan antar umat beragama. Kata Kunci: klenteng, struktur, fungsi, sumber belajar
Mixed Finite Element Matrix for Plate Bending Analysis Using Weighted-Residual Integral and Weak Formulation
Authors: Ahmed Abdarrhim Mohammed , Barony Saleh Y. 
Published: September 2020

The Conventional Finite Element Method for the analysis of plate bending based on a the principle of stationarity of total potential energy which is well known as Stiffness Formulation , using a variety of conformal and no-conformal elements was widely applicable in early of numerical solutions for such problems , later in order to improve the efficiency of such solutions , a more general and flexible formulation called Mixed Formulation based on variational principles which can be regarded as an extension of the Stiffness principle become important alternative. The explicit stiffness matrix for plate bending was given in the most if it`s not in all literatures so the reader can easy follow the solving procedure for such problems and verifying any published results , however such like-matrix (Augmented Matrix) in case of mixed formulation not given , at least for simple elements in the literatures as well as concerned researches . This quietly leads to some difficulties concerning the verification as well as understanding the published results. The main objective of this paper is to introduce this matrix in abbreviated size followed by a applicability through a some detailed examples for some bending models. The derived matrix will be helpful subject of research work in addition to , reveals a very good feeling with understanding and verification the published results in plus to comparing with the analytical solutions of different plate bending problems as the reader can do that.
The Assessment of the suitability of reconfigurable design through simulation and decision trees
Authors: Ramirez  Guzman Ricardo Irving , Chew Hernández Mario Luis , Viveros Rosas Mtro. Leopoldo , Figueroa Ricardo Rodríguez 
Published: September 2020

Positioning of the equipment of a manufacturing company is done foreseeing that it will remain fixed for a long time. This is because changes in the plant layout are thought to be costly, as they involve redesigning equipment support services, developing new foundations, using heavy machinery to move equipment, and causing non-productive time at the plant. However, the increased competition due to globalization, lead us to consider the alternative of making modifications to the layout more frequently to improve productivity. Changing the position of the equipment can be facilitated by specifying smaller mobile process equipment or by anticipating the availability of services at different points in the workshop and the existence of cranes or other means of transportation. These forecasts, logically, result in a greater investment in elements that, at least initially, do not generate any profit.
This work shows the evaluation of the feasibility of modifying the positions of the equipment when there are variations in the probability distribution in production speeds. This evaluation is carried out using decision trees and process simulation. The case study addressed consists of a generic production line with serial workstations. Jobs arrive at the first computer and join their product on hold if space is available, otherwise the job is lost. In the same way, the product on hold of the other teams are limited in size, and when a product on hold is full, the team behind stops until there is space available. Due to the use, the speeds of the equipment are changing with respect to the ones they had when new: the process times are increasing and / or becoming more variable. To improve productivity under the new process speeds, the space between the equipment can be modified, however, during this change, production must be suspended.
This work shows how, by simulating processes and decision trees, it is possible to determine the ranges of values ​​of the suspension time and the cost of transport for which it is convenient to make changes in the spacing of the equipment.
Indoor Air Pollution and the Risk of Cardiovascular Disease
Authors: Al-Shammari Waffa Aswaq 
Published: September 2020

Objective: To measure an association between factors related to indoor air pollution and CVD in the Hail population of Saudi Arabia.
Methodology: A case control study was conducted in King Khalid hospitals. Convenience and random sampling techniques were used to recruit cases and controls. Structured Questionnaire was used to collect data from 302 CVD cases and 300 controls. Data analysis was carried out using SPSS 24.0 statistical software.
Results: The bivariate analysis showed significant association between (i) socio-demographic characteristics (ii) air quality and occupation related variables (iii) ventilation and cooking related factors and (iv) exposure of different types of smoke, and CVD (p<0.001). The independent risk factors of CVD by Multivariate logistic regression analysis with adjusted odds ratios of variables are: age groups (25-50 & >50 years) (2.95&22.84); education level (uneducated & primary) (4.39&2.64); cigarette smoking (1.89); shisha smoking (2.12), exposed to cigarette smoke (2.50); burning scented wood (3.09), burning of mosquito repellent (2.18) and kitchen type (2.83) (p<0.001).
Conclusions: This study shows various sources of air pollutants are associated with CVD. The composition of indoor and outdoor air is same in Hail city but amount of contaminants is high in indoor environments. Future studies longitudinal studies are required to confirm the findings of this study.