bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiopharmaceutical formulation and preliminary clinical dosimetry of [177Lu]Lu-DOTA-MGS5 for application in peptide receptor radionuclide therapy
Authors: Zavvar Taraneh Sadat , Hörmann Anton Amadeus , Konijnenberg Mark , Kraihammer Martin , Mair Christian , Kronthaler Ariane , Joosten Lieke , Laverman Peter , Gruber Leonhard , di Santo Gianpaolo , Decristoforo Clemens , Virgolini Irene , von Guggenberg Elisabeth 
Published: December 2024

Abstract

Purpose
Radiolabelled minigastrin (MG) analogues targeting the cholecystokinin-2 receptor (CCK2R) have proven to be a promising approach for peptide receptor radionuclide therapy (PRRT). In this study, we report on the radiopharmaceutical development and standardization of the preparation of [177Lu]Lu-DOTA-MGS5 using an automated synthesis module. Furthermore, we present the preclinical tests required to move forward towards a first therapeutic clinical trial as well as preliminary clinical dosimetry data.

Methods
Five individual batches of [177Lu]Lu-DOTA-MGS5 were synthesized and analysed according to predefined quality control specifications. Cell-based experiments and biodistribution studies were performed to evaluate the specific receptor binding and tumour uptake of the radiopharmaceutical formulation. A preclinical dosimetry study was carried out in tumour xenografted mice and a first dosimetry study was performed in a patient with small cell lung cancer.

Results
The automated cassette-based production of [177Lu]Lu-DOTA-MGS5 resulted in a product with high radiochemical purity of > 98% and high stability. The new radiopharmaceutical showed a favourable biodistribution profile in A431-CCK2R xenografted BALB/c nude mice. Pharmacokinetic data obtained in mice and dosimetry extrapolation demonstrated the feasibility of PRRT. In the preliminary patient-specific dosimetry study, a low risk of toxicity was shown and a mean absorbed dose of 12.5 ± 10.2 (1.2–28) Gy/GBq was calculated for delineable tumour lesions.

Conclusion
The radiopharmaceutical development and the preclinical/clinical results support the initiation of a first clinical trial to evaluate the therapeutic potential of [177Lu]Lu-DOTA-MGS5 in PRRT.
Unsolicited prizes in contests
Authors: Sela Aner 
Published: December 2024

AbstractWe study two identical contests in which players compete against each other in each contest. A player is awarded a prize if he wins one of the contests, and an additional prize if he wins both contests. We show that in the symmetric equilibrium of either simultaneous or sequential contests, each player’s expected payoff decreases with the value of the additional prize for winning both contests, implying that each player would prefer to be rewarded for winning only one of the contests but never for winning both. We then investigate another variant of two interdependent contests and show that, as in the previous models, additional prizes other than those for a single win may be unsolicited by the players.
A cosine similarity-based token subsampling method for vision transformer in cloud computing
Authors: Li Qi , Kaneko Hayata , Meng Lin 
Published: December 2024

Abstract
Deploying huge deep learning applications on resource-constrained edge devices is a challenging task. Cloud-based edge computing is a promising solution. Such as model partitioning, a portion of the deep learning model is deployed on the edge device; while, the remaining portion is executed by the cloud. Leveraging the computation power of edge devices, transmission latency is reduced, and bandwidth efficiency is increased. Recently, visual transformer models, supported by large datasets, have dominated in multiple vision tasks. However, model partitioning optimization methods for visual transformers are lacking. Therefore, the paper proposes a cosine similarity-based token subsampling method for visual transformer model partitioning to improve transmission efficiency. Tokens in the same class are subsampled and only the centroid tokens are uploaded. In the cloud, all tokens are reconstructed based on interpolation indexes. Three algorithm implementations are proposed and measured on PC, Jetson NANO and edge CPU Cortex-A53. The experimental results demonstrate that the recommended algorithm implementation can be executed with low-latency of 71.24 ms, and 35.65% transmitted data is reduced with an accuracy drop of 0.46%.
Effects of the COVID-19 pandemic on surgical treatment for thoracic malignant tumor cases in Japan: a national clinical database analysis
Authors: Shintani Yasushi , Yamamoto Hiroyuki , Sato Yukio , Inoue Masayoshi , Asakura Keisuke , Ito Hiroyuki , Uramoto Hidetaka , Okada Yoshinori , Sato Toshihiko , Fukui Mariko , Hoshikawa Yasushi , Chen-Yoshikawa Toyofumi Fengshi , Chida Masayuki , Ikeda Norihiko , Yoshino Ichiro 
Published: December 2024

Abstract

Objective
Surgical care has been significantly affected by the COVID-19 pandemic. This study was conducted to evaluate the effects of the pandemic on lung cancer and mediastinal tumor surgery.

Methods
Changes in the number of surgical procedures for lung cancer and mediastinal tumors were analyzed using the National Clinical Database of Japan. Patient characteristics, including disease stage and histological type, from 2019 to 2022 were evaluated using annual datasets.

Results
Comparisons with 2019 showed that the number of patients who underwent surgery for primary lung cancer or a mediastinal tumor decreased in 2020 and then remained stable. There were no clinically significant changes in the trend over the four-year period regarding the number of patients for each clinical and pathological stage of lung cancer. Regarding mediastinal tumors, there was no significant difference in tumor size between years. There was a slight change in the selection of surgical indication during the second quarter of 2020, although its impact on annual trends in the stage distribution for lung cancer and primary disease for mediastinal tumors was minimal.

Conclusions
Analyses of lung cancer and mediastinal tumor surgery cases in Japan during the COVID-19 pandemic showed no significant disease profile changes related to treatment delay.
In vitro bonding strength of denture teeth to denture base in CAD/CAM-milled, 3D-printed and conventional manufacturing processes
Authors: Löscher Marcel , Hahnel Sebastian , Lang Reinhold , Rosentritt Martin 
Published: December 2024

Abstract

Objectives
To investigate the survival rates and fracture resistance of dentures made from different teeth (milled, 3D-printed, fabricated), bases (milled, 3D-printed, pressed) and bonding combinations.

Materials and methods
Specimens (11 groups, n = 8 per group) were fabricated from combinations with a denture tooth (anterior tooth 21) and a denture base material. The groups consisted of combinations of teeth (6x), denture base materials (5x) and adhesive bonding options (4x). The teeth were printed, milled or prefabricated. The denture base was produced conventionally or was milled or 3D-printed. Two dentures were milled from one industrially produced block. The dentures were subjected to thermal and mechanical loading (TCML) and subsequent fracture test. Statistics: ANOVA, Bonferroni-test, Kaplan-Meier survival, Pearson correlation; α = 0.05.

Results
Mean loading cycles varied between 221,869 (8), 367,610 (11), 513,616 (6) 875,371 (3) and 9,000,030 (4). ANOVA revealed significant (p ≤ 0.001) different surviving cycles. Log Rank test showed significantly (p < 0.001) different loading cycles. Fracture force after TCML varied between 129.8 +/- 97.1 N (3) and 780.8 +/- 62.5 N (9). ANOVA comparison revealed significant (p < 0.001) different fracture loadings between the individual systems. Correlation was found between fracture force and loading cycles (0.587, p < 0.001).

Conclusions
Different survival rates and fracture forces were found for dentures made of different teeth (milled, 3D-printed, prefabricated), bases (milled, 3D-printed, pressed) and bonding combinations. Milled, pressed and prefabricated systems provided longer survival and fracture force than the other tested systems.

Clinical relevance
Optimal tooth-base combinations can help to produce a denture that is stable and resistant during clinical application.
Myotonic dystrophies: an update on clinical features, molecular mechanisms, management, and gene therapy
Authors: Rimoldi Martina , Lucchiari Sabrina , Pagliarani Serena , Meola Giovanni , Comi Giacomo Pietro , Abati Elena 
Published: December 2024

AbstractMyotonic dystrophies (DM) encompass a group of complex genetic disorders characterized by progressive muscle weakness with myotonia and multisystemic involvement. The aim of our paper is to synthesize key findings and advancements in the understanding of DM, and to underline the multidisciplinary approach to DM, emphasizing the importance of genetic counseling, comprehensive clinical care, and symptom management. We discuss the genetic basis of DM, emphasizing the role of repeat expansions in disease pathogenesis, as well as cellular and animal models utilized for studying DM mechanisms and testing potential therapies. Diagnostic challenges, such as determining the size of disease expansions and assessing mosaicism, are elucidated alongside emerging genetic testing methods. Therapeutic strategies, mainly for DM1, are also explored, encompassing small molecules, nucleic acid-based therapies (NATs), and genome/transcriptome engineering. The challenges of such a therapeutic delivery and immunogenic response and the importance of innovative strategies, including viral vectors and AAV serotypes, are highlighted within the text. While no curative treatments have been approved, supportive and palliative care remains essential, with a focus on addressing multisystemic complications and maintaining functional independence. Continued exploration of these therapeutic advancements offers hope for comprehensive disease management and potentially curative therapies for DM1 and related disorders.
Proton beam and carbon ion radiotherapy in skull base chordoma: a systematic review, meta-analysis and meta-regression with trial sequential analysis
Authors: Rodrigues Amanda Cyntia Lima Fonseca , Tos Salem M. , Shaaban Ahmed , Mantziaris Georgios , Trifiletti Daniel M. , Sheehan Jason 
Published: December 2024

AbstractChordomas are rare, locally aggressive tumors that have a high rate of recurrence, especially at the skull base. This systematic review and meta-analysis aimed to analyze the efficacy and safety of proton beam therapy (PBT) and carbon ion radiotherapy (CIRT) for skull base chordoma. We conducted a systematic search of MEDLINE, EMBASE, CENTRAL, Web of Science, and Ovid up to November 26, 2023, following the PRISMA statement. Studies involving more than 10 patients with skull base chordoma treated with PBT or CIRT were included. The outcomes analyzed were local control, overall survival, progression-free survival, and toxicities. Meta-analysis was performed using the Mantel–Haenszel method and the inverse variance method. Fourteen studies met the inclusion criteria, encompassing 1,145 patients (671 treated with PBT and 474 with CIRT). No significant difference was found between PBT and CIRT for 5-year local control (LC) and overall survival (OS). The only timepoint with a difference in local control was at 3 years, when PBT showed an advantage in local control (90% vs. 83% for CIRT; p = 0.05) and progression-free survival was similar (94% for PBT vs. 83% for CIRT; p = 0.09). Sensitivity analysis and meta-regression revealed no significant influence of predefined parameters on outcomes. Publication bias was suggested by asymmetrical funnel plots. Both PBT and CIRT are effective treatments for skull base chordoma, with comparable long-term efficacy. This meta-analysis underscores the need for individualized treatment approaches and further research to refine these therapies in clinical practice.
GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function
Authors: Torrens-Mas Margalida , Navas-Enamorado Cayetano , Galmes-Panades Aina , Masmiquel Luis , Sanchez-Polo Andrés , Capo Xavier , Gonzalez-Freire Marta 
Published: December 2024

Abstract
Growth differentiation factor 15 (GDF-15) has emerged as a significant biomarker of aging, linked to various physiological and pathological processes. This study investigates circulating GDF-15 levels in a cohort of healthy individuals from the Balearic Islands, exploring its associations with biological age markers, including multiple DNA methylation (DNAm) clocks, physical performance, and other age-related biomarkers. Seventy-two participants were assessed for general health, body composition, and physical function, with GDF-15 levels quantified using ELISA. Our results indicate that GDF-15 levels significantly increase with age, particularly in individuals over 60. Strong positive correlations were observed between GDF-15 levels and DNAm GrimAge, DNAm PhenoAge, Hannum, and Zhang clocks, suggesting that GDF-15 could serve as a proxy for epigenetic aging. Additionally, GDF-15 levels were linked to markers of impaired glycemic control, systemic inflammation, and physical decline, including decreased lung function and grip strength, especially in men. These findings highlight the use of GDF-15 as a biomarker for aging and age-related functional decline. Given that GDF-15 is easier to measure than DNA methylation, it has the potential to be more readily implemented in clinical settings for broader health assessment and management.
Using temperature coefficients to support resonance assignment of intrinsically disordered proteins
Authors: Putko Paulina , Romero Javier Agustin , Pantoja Christian F. , Zweckstetter Markus , Kazimierczuk Krzysztof , Zawadzka-Kazimierczuk Anna 
Published: December 2024

Abstract
The resonance assignment of large intrinsically disordered proteins (IDPs) is difficult due to the low dispersion of chemical shifts (CSs). Luckily, CSs are often specific for certain residue types, which makes the task easier. Our recent work showed that the CS-based spin-system classification can be improved by applying a linear discriminant analysis (LDA). In this paper, we extend a set of classification parameters by adding temperature coefficients (TCs), i.e., rates of change of chemical shifts with temperature. As demonstrated previously by other groups, the TCs in IDPs depend on a residue type, although the relation is often too complex to be predicted theoretically. Thus, we propose an approach based on experimental data; CSs and TCs values of residues assigned using conventional methods serve as a training set for LDA, which then classifies the remaining resonances. The method is demonstrated on a large fragment (1-239) of highly disordered protein Tau. We noticed that adding TCs to sets of chemical shifts significantly improves the recognition efficiency. For example, it allows distinguishing between lysine and glutamic acid, as well as valine and isoleucine residues based on

$${{\text {H}}^{\text {N}}}$$

H

N

, N,

$${{\text {C}}_\alpha }$$

C
α

and C

$$^{\prime }$$

′

data. Moreover, adding TCs to CSs of

$${{\text {H}}^{\text {N}}}$$

H

N

, N,

$${{\text {C}}_\alpha }$$

C
α

, and C

$$^{\prime }$$

′

is more beneficial than adding

$${{\text {C}}_\beta }$$

C
β

CSs. Our program for LDA analysis is available at https://github.com/gugumatz/LDA-Temp-Coeff.
On Geometric-type Approximations with Applications
Authors: Daly Fraser , Lefèvre Claude 
Published: December 2024

AbstractWe explore two aspects of geometric approximation via a coupling approach to Stein’s method. Firstly, we refine precision and increase scope for applications by convoluting the approximating geometric distribution with a simple translation selected based on the problem at hand. Secondly, we give applications to several stochastic processes, including the approximation of Poisson processes with random time horizons and Markov chain hitting times. Particular attention is given to geometric approximation of random sums, for which explicit bounds are established. These are applied to give simple approximations, including error bounds, for the infinite-horizon ruin probability in the compound binomial risk process.
Is sustainable entrepreneurship profitable? ESG disclosure and the financial performance of SMEs
Authors: Momtaz Paul P. , Parra Isabel M. 
Published: December 2024

AbstractSustainability practices have a positive effect on the financial performance of SMEs. We extract ESG-related information for a sample of Spanish SMEs over the period 2012–2022 using tools provided by the Internet Archive to estimate a staggered difference-in-differences model of how the release of new ESG-related information impacts the financial performance of SMEs. ESG-related information can be delivered as an endogenous signal or as an exogenous certification. We show that both types of ESG-related information have a positive effect on SMEs’ financial performance and that both are informational substitutes. We also show that institutional change in the form of the 2015 Paris Agreement on Climate Change moderated the sustainability–performance relation. Specifically, post-Paris, the value-creating impact of exogenous ESG certification increased, while endogenous ESG signals without external certification became ineffective or detrimental. Finally, in line with CSR-as-insurance theory, we show that SMEs with higher performance variability benefit more from sustainability orientation.
Bis(glycinium) oxalate: effect of deuteration, single crystal neutron diffraction and Raman spectroscopic studies
Authors: Chitra R. , Choudhury R. R. , Abraham Geogy J. 
Published: December 2024

AbstractThe crystal structure of bis(glycinium) oxalate (BGO) is stabilized by a very strong O–H..O hydrogen bond apart from N–H…O and C-H…O hydrogen bonds. To probe the effect of deuteration on these hydrogen bonds, fully deuterated (FDBGO), C-deuterated(CDBGO), and N-deuterated bis(glycinium) oxalate (NDBGO) crystals were grown. Single crystal neutron diffraction and Raman spectroscopic studies were carried out. It was found from neutron diffraction studies that the O…O distance of the O–H…O hydrogen bond reduced on deuteration showing an inverse Ubbelohde effect. The neutron diffraction and Raman spectroscopic studies also revealed partial deuteration. The DSC studies showed no phase transition. Variation of the melting point amongst the four crystals was in a very small range from 151 to 158 °C.
Dichromate Contaminated Water Treatment using Novel Crystal Violet Azo Dye- Sulphonated Poly(Glycidyl methacrylate) Nano-Composite Adsorbent
Authors: Tamer Tamer M. , Khalifa Randa E. , Abou-Krisha Mortaga M. , Omer Ahmed M. , Alhamzani Abdulrahman G. , Youssef Mohamed E. , Yousef Tarek A. , Salem Mostafa E. , Mohy-Eldin Mohamed S. 
Published: December 2024

Abstract
In this study, the Cr(VI) metal ions have been removed from dichromate-contaminated water using a novel Azo Dye-Sulphonated Poly (glycidyl methacrylate) nano-composite adsorbent for the first time. Crystal violet Azo dye model (CV) has been immobilized onto nano-sulfonated Poly (glycidyl methacrylate) particles (SPGMA) through the adsorption process to obtain the novel crystal violet Azo Dye-Sulphonated Poly (glycidyl methacrylate) nano-composite adsorbent (CV-SPGMA). The effect of the adsorption conditions on the removal process of Cr (VI) metal ions such as dichromate concentration, adsorption time, temperature, pH, adsorbent dose, and finally agitation speed on the Cr(VI) metal ions removal was studied. The Cr(VI) metal ions removal process has been characterized using isotherms, kinetics, and thermodynamics models. The developed novel CV-SPGMA nano-composite adsorbent chemical structure and morphology were characterized using characterization tools such as FTIR, TGA, and SEM-EDAX analyses before and after the adsorption process. The developmentof the novel CV-SPGMA nano-composite adsorbent for the removal of Cr(VI) ions from dichromate-contaminated waters under mild adsorption conditions opens a new field of multiuse of the same adsorbent in the removal of more than one contaminant.
The Norwegian version of the Personal Feelings Questionnaire-2: clinical utility and psychometric properties
Authors: Vigfusdottir Johanna , Høidal Reidun , Breivik Edvard , Jonsbu Egil , Dale Karl Yngvar , Mork Erlend 
Published: December 2024

Abstract
Shame and guilt are universal emotions meant to elicit socially approved behaviors and inhibit antisocial behavior. Excessive feelings of shame and guilt—shame especially—are linked to various destructive behaviors, difficulties in emotion regulation, maladaptive personality traits, psychological difficulties, and negative impacts on treatment outcomes. These make it especially important to have a valid instrument to evaluate the mechanisms related to these emotions. No validated self-report instrument measuring generalized shame and guilt was available in Norwegian. The Personal Feelings Questionnaire (PFQ-2) is designed to measure the level of generalized shame and guilt. This project’s aim was to translate the PFQ-2 into Norwegian and evaluate the clinical utility and psychometric properties of a Norwegian version of the PFQ-2. Data were collected from students at a local university college in Norway (N = 320, age: M = 25.4, SD = 8) and patients at a local outpatient psychiatric hospital (N = 53, age: M = 31.4, SD = 10.43). To be able to evaluate the factor structure of the Norwegian version of the PFQ-2, the dataset was divided in two by random selection with a 50/50 split. First an Exploratory factor analysis (EFA) was conducted on one half of the sample (N = 180) and then a Confirmatory factor analysis (CFA) on the other half (N = 193). According to the EFA the factor structure was similar to the original factor structure, with the exception of one item (item 6). Confirmatory factor analysis showed a good goodness of fit for the two factors measuring shame and guilt. The internal consistency was high in both subscales (shame, α = 0.818, and guilt, α = 0.834). The instrument showed further adequate construct validity, where the clinical sample experienced greater shame than the community sample (M = 17, SD = 6.887 vs. M = 13, SD = 5.311) and stronger guilt (M = 18, SD = 5.248 vs. M = 14, SD = 15.210). The subscales correlated with other constructs, as expected. The PFQ-2—with the suggested adjustment of moving one item (item 6) from the shame scale to the guilt scale—can be used to evaluate the levels of feelings of shame and guilt among adults in Norway.