bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined magnetic and gravity measurements probe the deep zonal flows of the gas giants
Authors: Galanti E , Kaspi Y 
Published: November 2020

ABSTRACT
During the past few years, both the Cassini mission at Saturn and the Juno mission at Jupiter provided measurements with unprecedented accuracy of the gravity and magnetic fields of the two gas giants. Using the gravity measurements, it was found that the strong zonal flows observed at the cloud level of the gas giants are likely to extend thousands of kilometres deep into the planetary interior. However, the gravity measurements alone, which are by definition an integrative measure of mass, cannot constrain with high certainty the exact vertical structure of the flow. Taking into account the recent Cassini magnetic field measurements of Saturn, and past secular variations of Jupiter’s magnetic field, we obtain an additional physical constraint on the vertical decay profile of the observed zonal flows on these planets. Our combined gravity–magnetic analysis reveals that the cloud-level winds on Saturn (Jupiter) extend with very little decay, i.e. barotropically, down to a depth of around 7000 km (2000 km) and then decay rapidly in the semiconducting region, so that within the next 1000 km (600 km) their value reduces to about 1 per cent of that at the cloud level. These results indicate that there is no significant mechanism acting to decay the flow in the outer neutral region, and that the interaction with the magnetic field in the semiconducting region might play a central role in the decay of the flows.
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway
Authors: Wang Yingying , Li Nianyu , Zeng Zhengyan , Tang Li , Zhao Shuhua , Zhou Fang , Zhou Liping , Xia Wei , Zhu Changhong , Rao Meng 
Published: November 2020

Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic and ovarian oxidative stress (OS) imbalance is a pivotal feature of PCOS. Humanin, a mitochondria-derived peptide, has been reported to function as an antioxidant in cardiomyocytes, pancreatic beta cells and other cells, but how this function is regulated remains unclear. In this study, we investigated whether humanin expression differs in the granulosa cells (GCs) of PCOS patients versus controls, and whether humanin alleviates OS in PCOS ovaries. Sixteen PCOS patients and 28 age- and BMI-matched controls undergoing IVF were recruited, and their serum, follicular fluid and GCs were collected for humanin analysis. Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism. Humanin expression was significantly down-regulated in the ovaries of PCOS patients relative to those of non-PCOS patients. Exogenous humanin supplementation significantly attenuated body weight gain, ovarian morphological abnormalities, endocrinological disorders and ovarian and systemic OS in PCOS rat models. Our study further demonstrated that this attenuation effect was involved in the modulation of the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor-erythroid 2-related factor 2 (Nrf2) signalling pathway. In summary, this study reported for the first time that decreased expression of humanin in the GCs was associated with oxidative imbalance in PCOS. Humanin alleviates OS in ovarian GCs of PCOS patients via modulation of the Keap1/Nrf2 signalling pathway.
NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV
Authors: Zhao Bailin , Naila Tasmin , Lieber Michael R , Tomkinson Alan E 
Published: November 2020

AbstractAs nucleotidyl transferases, formation of a covalent enzyme-adenylate intermediate is a common first step of all DNA ligases. While it has been shown that eukaryotic DNA ligases utilize ATP as the adenylation donor, it was recently reported that human DNA ligase IV can also utilize NAD+ and, to a lesser extent ADP-ribose, as the source of the adenylate group and that NAD+, unlike ATP, enhances ligation by supporting multiple catalytic cycles. Since this unexpected finding has significant implications for our understanding of the mechanisms and regulation of DNA double strand break repair, we attempted to confirm that NAD+ and ADP-ribose can be used as co-factors by human DNA ligase IV. Here, we provide evidence that NAD+ does not enhance ligation by pre-adenylated DNA ligase IV, indicating that this co-factor is not utilized for re-adenylation and subsequent cycles of ligation. Moreover, we find that ligation by de-adenylated DNA ligase IV is dependent upon ATP not NAD+ or ADP-ribose. Thus, we conclude that human DNA ligase IV cannot use either NAD+ or ADP-ribose as adenylation donor for ligation.
The Impact of Including Cessation Resource Information on Health Warnings on Standardized Tobacco Packaging on Awareness and Use: A Longitudinal Online Survey in the United Kingdom
Authors: Moodie Crawford , Best Catherine , Critchlow Nathan , Stead Martine , McNeill Ann , Hitchman Sara 
Published: November 2020

Abstract

Introduction
Since May 2017, all cigarettes and roll-your-own (RYO) tobacco in the United Kingdom must be sold in standardized packs with pictorial warnings displaying, for the first time, a stop-smoking website.

Aims and Methods
Data come from three waves of a longitudinal online survey with smokers and ex-smokers conducted pre- and post-standardized packaging, with Wave 1 (W1) in April–May 2016, Wave 2 (W2) in September–November 2017, and Wave 3 (W3) in May–July 2019. Only smokers are included in the analysis: W1 (N = 6233), W2 (N = 3629), and W3 (N = 2412). We explored any change in citing warnings on packs as a source of information about a stop-smoking website, and whether citing warnings as a source was associated with use of a stop-smoking website. As the warnings, and therefore the stop-smoking website, are larger on RYO packs than on cigarette packs due to the larger pack size, we explored differences in awareness of a stop-smoking website among exclusive cigarette smokers (W1 = 3142, W2 = 1884, W3 = 1247) and exclusive RYO smokers (W1 = 2046, W2 = 1119, W3 = 814).

Results
Among smokers recalling seeing information about a stop-smoking website, citing warnings as a source increased between waves (W1 = 14.0%, W2 = 24.2%, W3 = 25.1%) and was associated with having visited a stop-smoking website (odds ratio = 11.81, 95% confidence interval 8.47–16.46). Citing warnings as a source of a stop-smoking website increased among exclusive RYO smokers at each wave (W1 = 15.5%, W2 = 26.3%, W3 = 32.1%), while for exclusive cigarette smokers it only increased at W2 (W1 = 10.5%, W2 = 22.4%, W3 = 19.9%).

Conclusions
Warnings are an important source of cessation resource information. Making this information more prominent may help sustain awareness.

Implications
The findings support the inclusion of a stop-smoking website on warnings as awareness among smokers increased and citing warnings as a source of information about a stop-smoking website was associated with having visited a stop-smoking website. We also explored whether the stop-smoking website on warnings on RYO packs, which is larger than on cigarette packs as a function of the larger size of RYO packs, would have any impact on awareness of this information. That exclusive RYO smokers were more likely than exclusive cigarette smokers to notice a stop-smoking website on warnings suggests that this information should be more prominent.
Anti-tumour necrosis factor treatment for the prevention of ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2)
Authors: Cooray Samantha , Omyinmi Ebun , Hong Ying , Papadopoulou Charalampia , Harper Lorraine , Al-Abadi Eslam , Goel Ruchika , Dubey Shirish , Wood Mark , Jolles Stephen , Berg Stefan , Ekelund Maria , Armon Kate , Eleftheriou Despina , Brogan Paul A 
Published: November 2020

Abstract

Objective
To evaluate the impact of anti-Tumour Necrosis Factor-α (anti-TNF) treatment on the occurrence of vasculitic ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2).

Methods
A retrospective analysis of DADA2 patients referred from six centres to Great Ormond Street Hospital for Children was conducted. Ischaemic events, vasculitic disease activity, biochemical, immunological, and radiological features were compared, before and after anti-TNF treatment.

Results
A total of 31 patients with genetically confirmed DADA2 were included in the study. The median duration of active disease activity prior to anti-TNF treatment was 73 months (inter-quartile range [IQR] 27.5–133.5 months). Twenty seven/31 patients received anti-TNF treatment for a median of 32 months (IQR 12.0–71.5 months). The median event rate of central nervous system (CNS) and non-CNS ischemic events before anti-TNF treatment was 2.37 per 100 patient-months (IQR 1.25–3.63); compared with 0.00 per 100 patient-months (IQR 0.0–0.0) post-treatment (p&lt; 0.0001). Paediatric vasculitis activity score (PVAS) was also significantly reduced: median score of 20/63 (IQR 13.0–25.8/63) pre-treatment vs. 2/63 (IQR 0.0–3.8/63) following anti-TNF treatment (p&lt; 0.0001), with mild livedoid rash being the main persisting feature. Anti-TNF treatment was not effective for severe immunodeficiency or bone marrow failure, which required haematopoietic stem cell transplantation (HSCT).

Conclusion
Anti-TNF treatment significantly reduced the incidence of ischaemic events and other vasculitic manifestations of DADA2, but was not effective for immunodeficiency or bone marrow failure.
CONDUCTION BAND-VALENCE BAND THEORY OF TL AND OSL: EMPHASIS ON DELOCALIZED TRANSITIONS AND EXPLANATION ON SOME UNUSUAL EFFECTS
Authors: Chen Reuven 
Published: November 2020

Abstract
We discuss some unusual thermoluminescence (TL) and optically stimulated luminescence effects. We focus on luminescence due to transitions of electrons or holes through the conduction or valence band, respectively. We deal with non-linear dose dependence and non-monotonic dose dependence and also dose-rate effects sometimes reported. Also, is discussed the sensitisation of a sample due to the combined effect of irradiation and annealing, occurring in quartz samples and other materials. Another effect presented is the occurrence of anomalously high activation energies and frequency factors and its possible theoretical interpretation. Also, are considered the effects of anomalous fading and anomalous stability. Yet another phenomenon is concentration quenching. Here, the intensity of emitted TL depends non-monotonically on the concentration of the impurity responsible for the emission. The explanations given to these phenomena are based on the numerical solutions of the relevant sets of differential equations as well as approximate analytical treatment.
Heterogeneity and Classification of Recent Onset Psychosis and Depression: A Multimodal Machine Learning Approach
Authors: Lalousis Paris Alexandros , Wood Stephen J , Schmaal Lianne , Chisholm Katharine , Griffiths Sian Lowri , Reniers Renate L E P , Bertolino Alessandro , Borgwardt Stefan , Brambilla Paolo , Kambeitz Joseph , Lencer Rebekka , Pantelis Christos , Ruhrmann Stephan , Salokangas Raimo K R , Schultze-Lutter Frauke , Bonivento Carolina , Dwyer Dominic , Ferro Adele , Haidl Theresa , Rosen Marlene , Schmidt Andre , Meisenzahl Eva , Koutsouleris Nikolaos , Upthegrove Rachel ,   PRONIA Consortium
Published: November 2020

Abstract
Diagnostic heterogeneity within and across psychotic and affective disorders challenges accurate treatment selection, particularly in the early stages. Delineation of shared and distinct illness features at the phenotypic and brain levels may inform the development of more precise differential diagnostic tools. We aimed to identify prototypes of depression and psychosis to investigate their heterogeneity, with common, comorbid transdiagnostic symptoms. Analyzing clinical/neurocognitive and grey matter volume (GMV) data from the PRONIA database, we generated prototypic models of recent-onset depression (ROD) vs. recent-onset psychosis (ROP) by training support-vector machines to separate patients with ROD from patients with ROP, who were selected for absent comorbid features (pure groups). Then, models were applied to patients with comorbidity, ie, ROP with depressive symptoms (ROP+D) and ROD participants with sub-threshold psychosis-like features (ROD+P), to measure their positions within the affective-psychotic continuum. All models were independently validated in a replication sample. Comorbid patients were positioned between pure groups, with ROP+D patients being more frequently classified as ROD compared to pure ROP patients (clinical/neurocognitive model: χ2 = 14.874; P &lt; .001; GMV model: χ2 = 4.933; P = .026). ROD+P patient classification did not differ from ROD (clinical/neurocognitive model: χ2 = 1.956; P = 0.162; GMV model: χ2 = 0.005; P = .943). Clinical/neurocognitive and neuroanatomical models demonstrated separability of prototypic depression from psychosis. The shift of comorbid patients toward the depression prototype, observed at the clinical and biological levels, suggests that psychosis with affective comorbidity aligns more strongly to depressive rather than psychotic disease processes. Future studies should assess how these quantitative measures of comorbidity predict outcomes and individual responses to stratified therapeutic interventions.
Detecting Phylogenetic Signal and Adaptation in Papionin Cranial Shape by Decomposing Variation at Different Spatial Scales
Authors: Grunstra Nicole D S , Bartsch Silvester J , Le Maître Anne , Mitteroecker Philipp 
Published: November 2020

AbstractPhylogenetic reconstruction based on morphometric data is hampered by homoplasies. For example, many similarities in cranial form between primate taxa more strongly reflect ecological similarities rather than phylogenetic relatedness. However, the way in which the different cranial bones constitute cranial form is, if at all, of less functional relevance and thus largely hidden from selection. We propose that these “constructional details” are better indicators of phylogenetic history than any large-scale shape feature or raw form variable. Within a geometric morphometric context, we show how to analyze the relative extent of bones independently of differences in overall shape. We also show how to decompose total shape variation into small-scale and large-scale shape variation. We apply both methods to the midsagittal cranial morphology of papionin monkeys, which are well known for the discrepancy between morphological similarities and phylogenetic relationships. We study phylogenetic signal and functional adaptation using a molecular phylogeny and contextual data on feeding ecology and locomotor behavior. As expected, total cranial shape, bone outline shape, and large-scale shape features were only weakly associated with phylogenetic distance. But the relative bone contributions and small-scale shape features were both highly correlated with phylogenetic distances. By contrast, the association with ecological and behavioral variables was strongest for the outline shape and large-scale shape features. Studies of morphological adaptation and phylogenetic history thus profit from a decomposition of shape variation into different spatial scales. [Adaptation; canalization; cranial shape; geometric morphometrics; papionini; partial warps; phylogeny.]
Multiple extensive Madurella mycetomatis eumycetoma lesions: a case report and review of the literature
Authors: Zaid Dania M , Bakheet Osama E , Ahmed Eiman Siddig , Abdalati Fatima , Mhmoud Najwa A , Mohamed El Samani Wadaa , Bakhiet Sahar Mubarak , Siddig Emmanuel Edwar , Fahal Ahmed Hassan 
Published: November 2020

Abstract
In this communication, we report on the first-ever patient presenting with 17 lesions of Madurella mycetomatis eumycetoma in different parts of the body. The reported patient is a 15-y-old female who presented to the Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan, in 2017 with recurrent back and anterior abdominal wall eumycetoma lesions. They were surgically excised, and during the course of follow-up, she developed 15 other eumycetoma lesions, scattered mostly on her upper and lower limbs and gluteal region. The diagnosis of Madurella mycetomatis was confirmed by molecular identification of grains and culture, histopathological examination and ultrasound examination. The cause and the explanation of such a presentation in puzzling; it is not due to multiple subcutaneous implantations because of the lack of history of relevant local trauma. Lymphatic spread is unlikely as the distribution of the lesions is not in line with this. Haematogenous spread is a possible explanation. This rare presentation of eumycetoma poses a great challenge for diagnosis and management.
Extensive perineal Actinomadura pelletieri actinomycetoma-induced urethral stricture: a rare complication
Authors: Bakheet Osama Elhadi , Hassan Muawia Ahmed , Fahal Ahmed Hassan 
Published: November 2020

Abstract
Mycetoma is a neglected tropical disease that causes tremendous suffering and misery to affected patients. In Sudanese rural communities, many patients hide their lesions, especially those located in the perineal, scrotal, inguinal and genital regions, and they regard them as sources of social stigma. We report the case of a 45-year-old male from northern Kordofan State, Sudan, who presented with multiple discharging sinuses in the perineal region. Clinical diagnosis was actinomycetoma and fine-needle aspiration cytology was consistent with Actinomadura pelletieri, confirmed by culture and biochemical analysis. To our knowledge, this is the first case of A. pelletieri with urethral complications and subsequent implications for management.
Biomarkers in the prediction of multimorbidity: scoping review
Authors: Spencer EA , Ford GA , Chan MS , Perera R , Heneghan CJ 
Published: November 2020

AbstractBackgroundMultimorbidity presents an increasing challenge in the global ageing population. Predicting its development is necessary to help design and deliver effective healthcare.ObjectiveThis scoping review aimed to collate and present the body of published evidence on biomarkers and multimorbidity, identifying what work has been done and what gaps remain.MethodsWe searched the electronic databases MEDLINE, Register of Controlled Trials (Cochrane CENTRAL), CINAHL, PsycINFO, EMBASE, Scopus, Web of Science and TRIP database up until 11 August 2020 and hand-searched the reference lists of included articles.ResultsWe found 34 relevant studies including 12 reporting prospective data and 22 reporting cross-sectional data. These encompassed 14 studies on serum biomarkers, 2 on molecular biomarkers, 7 on physiological biomarkers, 8 on body size biomarkers and 3 on brain function biomarkers. Most studies were undertaken in European or North American populations. There was a broadly consistent finding that obesity was associated with increased multimorbidity. Other results were more varied, reflecting the diverse range of biomarkers investigated, and lack of standardisation of multimorbidity outcome definitions.Longitudinal studies have been set up that are maturing and further evidence can be expected over time.ConclusionThere has been limited research on biomarkers to predict the development of multimorbidity, with minimal investigation of putative biomarkers identified in basic research. High quality research studies in this area are needed to progress the development of targeted interventions to prevent or delay the onset of multimorbidity.
Are we ready for COVID-19’s Golden Passport? Insights from a Global Physician Survey
Authors: Doraiswamy P. Murali , Chilukuri Mohan , Linares Alexandra R. , Bramstedt Katrina A. 
Published: November 2020

ABSTRACTIntroductionCOVID-19 immunity passports could protect the right to free movement, but critics worry about insufficient evidence, privacy, fraud, and discrimination. We aimed to characterize the global physician community’s opinion regarding immunity passports.MethodsCross sectional, random stratified sample of physicians registered with Sermo, a global networking platform open to verified and licensed physicians. The survey aimed to sample 1,000 physicians divided among the USA, EU and rest of the world. The survey question on immunology asked physicians to offer their insights into whether we know enough about COVID-19 immunity and its duration to offer immunity passports at the present time.ResultsThe survey was completed by 1004 physicians (67 specialties, 40 countries, 49% frontline specialties) with a mean (SD) age of 49.14 (12) years. Overall, 52% answered NO, 17% were UNCERTAIN, and 31% answered YES (P <0.05). EU physicians were more likely to sayYES but even among them it did not exceed 35% approval. US physicians (60%) were more likely to say NO.ConclusionOur findings suggest a current lack of support among physicians for immunity passports. It is hoped that ongoing research and vaccine trials will provide further clarity.
Current methods integrating variant functional annotation scores have limited capacity to improve the power of genome-wide association studies
Authors: Gao Jianhui , Espin-Garcia Osvaldo , Paterson Andrew D. , Sun Lei 
Published: November 2020

AbstractFunctional annotations have the potential to increase the power of genome-wide association studies (GWAS) by prioritizing variants according to their biological function. Focusing on variant-specific annotation meta-scores including CADD (Kircher et al., 2014) and Eigen (Ionita-laza et al., 2016), we broadly examined GWAS summary statistics of 1,132 traits from the UK Biobank (Sudlow et al., 2015) using the weighted p-value approach (Genovese et al., 2006) and stratified false discovery control (sFDR) method (Sun et al., 2006). These 1,132 traits were rated by Benjamin Neale’s lab from the Broad Institute as having medium to high confidence for their heritability estimates.Averaged across the 1,132 UK Biobank traits, sFDR was more robust to uninformative meta-scores, but the weighted p-value method identified more variants using CADD or Eigen, based on performance measures that included type I error control, recall, precision, and relative efficiency. Our application results were consistent with those from an extensive simulation study using three different designs, including leveraging the real genetic data combined with simulated genomic data and vice versa.We also considered the recent FINDOR method (Kichaev et al., 2019), which leverages a set of individual 75 functional annotations into GWAS. An earlier application of FINDOR to 27 traits selected from the z7 category (SNP-heritability p-value < 1.27 × 10−12by Nealelab) detected 13%-20% additional genome-wide significant loci as compared to the standard annotation-free GWAS, which we confirmed. Moreover, across all 438 traits in the z7 category, 46,631 out 59,764 (80%) significant loci discovered are common across the three data-integration methods.However, across all the 1,132 UK Biobank traits examined, the median [Q1,Q3] of the total numbers of new, genome-wide significant independent loci were 0 [0, 3] by FINDOR, 0 [0, 2] by weighted p-value, and 0 [0, 0] by sFDR. Notably, 162 traits (89%) in the nonsig trait category (SNP-heritability p-value > 0.05, “likely reflecting limited statistical power rather than a true lack of heritability” by Nealelab) had no new discoveries after data-integration by any of the three methods. Our findings suggest that more informative scores or new data integration methods are warranted to further improve the power of GWAS by leveraging the variant functional annotations.