bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mineralization events in the Xiaokele porphyry Cu (–Mo) deposit, NE China: Evidence from zircon U–Pb and K‐feldspar Ar–Ar geochronology and petrochemistry
Authors: Sun Yonggang , Li Bile , Sun Fengyue , Ding Qingfeng , Wang Baiyi , Li Yujin , Wang Kun 
Published: March 2020

AbstractThe Great Xing'an Range (GXR), Northeast (NE) China, is a major polymetallic metallogenic belt in the eastern segment of the Central Asian Orogenic Belt. The newly discovered Xiaokele porphyry Cu (–Mo) deposit lies in the northern GXR. Field geological and geochronological studies have revealed two mineralization events in this deposit: early porphyry‐type Cu (–Mo) mineralization, and later vein‐type Cu mineralization. Previous geochronological studies yielded an age of ca. 147 Ma for the early Cu (–Mo) mineralization. Our 40Ar/39Ar dating yielded 40Ar/39Ar plateau ages of 124.8 ± 0.4 to 124.3 ± 0.4 Ma on K‐feldspar in altered Cu‐mineralized diorite porphyrite dikes that represent the overprinting vein‐type Cu mineralization, consistent with zircon U–Pb ages of the diorite porphyrite (126.4 ± 0.5 to 125.0 ± 0.5 Ma). The Cr and Ni contents and Mg# of the Xiaokele diorite porphyrites are high. The diorite porphyrites at Xiaokele are enriched in light rare‐earth elements (REEs), and large‐ion lithophile elements (e.g., Rb, Ba, and K), are depleted in heavy REEs and high‐field‐strength elements (e.g., Nb, Ta, and Ti), and have weak negative εHf(t) values (+0.29 to +5.27) with two‐stage model ages (TDM2) of 1,164–845 Ma. Given the regional tectonic setting in Early Cretaceous, the ore‐bearing diorite porphyrites were likely formed in an extensional environment related to lithospheric delamination and asthenospheric upwelling induced by subduction of the Paleo‐Pacific Plate. These tectonic events caused large‐scale magmatic activity, ore mineralization, and lithospheric thinning in NE China.
Gastrocnemius Medialis and Vastus Lateralis in vivo muscle‐tendon behavior during running at increasing speeds
Authors: Monte Andrea , Baltzopoulos Vasilios , Maganaris Constantinos N. , Zamparo Paola 
Published: March 2020

This study combines in vivo ultrasound measurements of the Vastus Lateralis (VL) and Gastrocnemius Medialis (GM) muscles with electromyographic, kinematic, and kinetic measurements during treadmill running at different speeds (10, 13, and 16 km/h) to better understand the role of muscle and tendon behavior in two functionally different muscle‐tendon units. In addition, the force‐length and force‐velocity relationships of VL and GM were experimentally assessed by combining dynamometry and EMG data with ultrasound measurements. With increasing running speed, the operating length of the fascicles in the stance phase shifted toward smaller lengths in the GM (P < .05; moving down the ascending limb of the F‐L relationship) and longer lengths in the VL (P < .05; moving down the descending limb) at all speeds; however, both muscles contracted close to their optimal length L0, where isometric force is maximal. Whereas the length of VL SEE did not change as a function of speed, GM SEE lengthened and shortened more at higher speeds. With increasing running speed, the contribution of elastic strain energy to the positive power generated by the MTU increased more for GM (from 0.75 to 1.56 W/kg) than for VL (from 0.62 to 1.02 W/kg). Notwithstanding these differences, these results indicate that, at increasing running speeds, both the VL and GM muscles produce high forces at low contraction velocities, and that the primary function of both muscle‐tendon units is to enhance the storage and recovery of elastic strain energy.
Performance Evaluation of Alternating Current Square Waveform Submerged Arc Welding as a Candidate for Fabrication of Thick Welds in 2.25Cr-1Mo Heat-Resistant Steel
Authors: Mohanty Uttam Kumar , Abe Yohei , Fujimoto Takahiro , Nakatani Mitsuyoshi , Kitagawa Akikazu , Tanaka Manabu , Suga Tetsuo , Sharma Abhay 
Published: March 2020

AbstractThe paper evaluates the performance of alternating current (AC) square waveform submerged arc welding (SAW) as a candidate technology for manufacturing thick welds for high-pressure vessels. A new mathematical formulation for calculating melting efficiency in square waveform arc welding is presented. The melting efficiency and the heat consumption are presented as a mathematical model of welding parameters, namely welding current, welding speed, current frequency, and electrode negativity (EN) ratio. The proposed approach is demonstrated through the welding of 2.25Cr-1Mo heat-resistant steel performed over a wide range of welding parameters. The investigation provides deeper insights into the interplay between process parameter, total heat consumption, and melting efficiency. The effect on flux consumption is also explained. The melting efficiency is inversely proportional to flux consumption. The welding heat does not necessarily promote the plate melting. Improper use of welding heat may lead to decreased melting efficiency and increased unwanted melting and consumption of welding flux. Compared to the conventional direct current (DC) power sources, the AC square waveform welding achieves almost the same order of melting efficiency with added advantages of better weld bead shape and flux consumption in a desirable range. The two additional parameters (frequency and EN ratio) of the AC square waveform power source provide more freedom to fine-tune the process and thereby efficiently use welding heat. The results of this investigation will be advantageous to the designers and fabricators of high-pressure vessels using AC square waveform welding.
Cryptococcus neoformansChemotyping by Quantitative Analysis of1H Nuclear Magnetic Resonance Spectra of Glucuronoxylomannans with a Computer-Simulated Artificial Neural Network
Authors: Cherniak Robert , Valafar Homayoun , Morris Laura C. , Valafar Faramarz 
Published: March 2020

ABSTRACTThe complete assignment of the proton chemical shifts obtained by nuclear magnetic resonance (NMR) spectroscopy of de-O-acetylated glucuronoxylomannans (GXMs) fromCryptococcus neoformanspermitted the high-resolution determination of the total structure of any GXM. Six structural motifs based on an α-(1→3)-mannotriose substituted with variable quantities of 2-O-β- and 4-O-β-xylopyranosyl and 2-O-β-glucopyranosyluronic acid were identified. The chemical shifts of only the anomeric protons of the mannosyl residues served as structure reporter groups (SRG) for the identification and quantitation of the six triads present in any GXM. The assigned protons for the mannosyl residues resonated at clearly distinguishable positions in the spectrum and supplied all the information essential for the assignment of the complete GXM structure. This technique for assigning structure is referred to as the SRG concept. The SRG concept was used to analyze the distribution of the six mannosyl triads of GXMs obtained from 106 isolates ofC. neoformans. The six mannosyl triads occurred singularly or in combination with one or more of the other triads. The identification and quantitation of the SRG were simplified by using a computer-simulated artificial neural network (ANN) to automatically analyze the SRG region of the one-dimensional proton NMR spectra. The occurrence and relative distribution of the six mannosyl triads were used to chemotypeC. neoformanson the basis of subtle variations in GXM structure determined by analysis of the SRG region of the proton NMR spectrum by the ANN. The data for the distribution of the six SRGs from GXMs of 106 isolates ofC. neoformansyielded eight chemotypes, Chem1 through Chem8.
Spatial variations of incoming sediments at the northeastern Japan arc and their implications for megathrust earthquakes
Authors: Fujie Gou , Kodaira Shuichi , Nakamura Yasuyuki , Morgan Jason P. , Dannowski Anke , Thorwart Martin , Grevemeyer Ingo , Miura Seiichi 
Published: March 2020

Abstract
The nature of incoming sediments is a key controlling factor for the occurrence of megathrust earthquakes in subduction zones. In the 2011 Mw 9 Tohoku earthquake (offshore Japan), smectite-rich clay minerals transported by the subducting oceanic plate played a critical role in the development of giant interplate coseismic slip near the trench. Recently, we conducted intensive controlled-source seismic surveys at the northwestern part of the Pacific plate to investigate the nature of the incoming oceanic plate. Our seismic reflection data reveal that the thickness of the sediment layer between the seafloor and the acoustic basement is a few hundred meters in most areas, but there are a few areas where the sediments appear to be extremely thin. Our wide-angle seismic data suggest that the acoustic basement in these thin-sediment areas is not the top of the oceanic crust, but instead a magmatic intrusion within the sediments associated with recent volcanic activity. This means that the lower part of the sediments, including the smectite-rich pelagic red-brown clay layer, has been heavily disturbed and thermally metamorphosed in these places. The giant coseismic slip of the 2011 Tohoku earthquake stopped in the vicinity of a thin-sediment area that is just beginning to subduct. Based on these observations, we propose that post-spreading volcanic activity on the oceanic plate prior to subduction is a factor that can shape the size and distribution of interplate earthquakes after subduction through its disturbance and thermal metamorphism of the local sediment layer.
Epidemiology of multimorbidity in conditions of extreme poverty: a population-based study of older adults in rural Burkina Faso
Authors: Odland Maria Lisa , Payne Collin , Witham Miles D , Siedner Mark J , Bärnighausen Till , Bountogo Mamadou , Coulibaly Boubacar , Geldsetzer Pascal , Harling Guy , Manne-Goehler Jennifer , Ouermi Lucienne , Sie Ali , Davies Justine I 
Published: March 2020

IntroductionMultimorbidity is a health issue of increasing importance worldwide, and is likely to become particularly problematic in low-income countries (LICs) as they undergo economic, demographic and epidemiological transitions. Knowledge of the burden and consequences of multimorbidity in LICs is needed to inform appropriate interventions.MethodsA cross-sectional household survey collected data on morbidities and frailty, disability, quality of life and physical performance on individuals aged over 40 years of age living in the Nouna Health and Demographic Surveillance System area in northwestern Burkina Faso. We defined multimorbidity as the occurrence of two or more conditions, and evaluated the prevalence of and whether this was concordant (conditions in the same morbidity domain of communicable, non-communicable diseases (NCDs) or mental health (MH)) or discordant (conditions in different morbidity domains) multimorbidity. Finally, we fitted multivariable regression models to determine associated factors and consequences of multimorbidity.ResultsMultimorbidity was present in 22.8 (95% CI, 21.4 to 24.2) of the study population; it was more common in females, those who are older, single, more educated, and wealthier. We found a similar prevalence of discordant 11.1 (95% CI, 10.1 to 12.2) and concordant multimorbidity 11.7 (95% CI, 10.6 to 12.8). After controlling for age, sex, marital status, education, and wealth, an increasing number of conditions was strongly associated with frailty, disability, low quality of life, and poor physical performance. We found no difference in the association between concordant and discordant multimorbidity and outcomes, however people who were multimorbid with NCDs alone had better outcomes than those with multimorbidity with NCDs and MH disorders or MH multimorbidity alone.ConclusionsMultimorbidity is prevalent in this poor, rural population and is associated with markers of decreased physical performance and quality of life. Preventative and management interventions are needed to ensure that health systems can deal with increasing multimorbidity and its downstream consequences.
Protocol for a randomised trial of an interprofessional team-delivered intervention to support surrogate decision-makers in ICUs
Authors: Lincoln Taylor , Shields Anne-Marie , Buddadhumaruk Praewpannarai , Chang Chung-Chou H , Pike Francis , Chen Hsiangyu , Brown Elke , Kozar Veronica , Pidro Caroline , Kahn Jeremy M , Darby Joseph M , Martin Susan , Angus Derek C , Arnold Robert M , White Douglas B 
Published: March 2020

IntroductionAlthough shortcomings in clinician–family communication and decision making for incapacitated, critically ill patients are common, there are few rigorously tested interventions to improve outcomes. In this manuscript, we present our methodology for the Pairing Re-engineered Intensive Care Unit Teams with Nurse-Driven Emotional support and Relationship Building (PARTNER 2) trial, and discuss design challenges and their resolution.Methods and analysisThis is a pragmatic, stepped-wedge, cluster randomised controlled trial comparing the PARTNER 2 intervention to usual care among 690 incapacitated, critically ill patients and their surrogates in five ICUs in Pennsylvania. Eligible subjects will include critically ill patients at high risk of death and/or severe long-term functional impairment, their main surrogate decision-maker and their clinicians. The PARTNER intervention is delivered by the interprofessional ICU team and overseen by 4–6 nurses from each ICU. It involves: (1) advanced communication skills training for nurses to deliver support to surrogates throughout the ICU stay; (2) deploying a structured family support pathway; (3) enacting strategies to foster collaboration between ICU and palliative care services and (4) providing intensive implementation support to each ICU to incorporate the family support pathway into clinicians’ workflow. The primary outcome is surrogates’ ratings of the quality of communication during the ICU stay as assessed by telephone at 6-month follow-up. Prespecified secondary outcomes include surrogates’ scores on the Hospital Anxiety and Depression Scale, the Impact of Event Scale, the modified Patient Perception of Patient Centredness scale, the Decision Regret Scale, nurses’ scores on the Maslach Burnout Inventory, and length of stay during and costs of the index hospitalisation.We also discuss key methodological challenges, including determining the optimal level of randomisation, using existing staff to deploy the intervention and maximising long-term follow-up of participants.Ethics and disseminationWe obtained ethics approval through the University of Pittsburgh, Human Research Protection Office. The findings will be published in peer-reviewed journals.Trial registration numberNCT02445937
Accelerated partner therapy (APT) partner notification for people withChlamydia trachomatis: protocol for the Limiting Undetected Sexually Transmitted infections to RedUce Morbidity (LUSTRUM) APT cross-over cluster randomised controlled trial
Authors: Estcourt Claudia S , Howarth Alison R , Copas Andrew , Low Nicola , Mapp Fiona , Woode Owusu Melvina , Flowers Paul , Roberts Tracy , Mercer Catherine H , Wayal Sonali , Symonds Merle , Nandwani Rak , Saunders John , Johnson Anne M , Pothoulaki Maria , Althaus Christian , Pickering Karen , McKinnon Tamsin , Brice Susannah , Comer Alex , Tostevin Anna , Ogwulu Chidubem (Duby) , Vojt Gabriele , Cassell Jackie A 
Published: March 2020

IntroductionPartner notification (PN) is a process aiming to identify, test and treat the sex partners of people (index patients) with sexually transmitted infections (STIs). Accelerated partner therapy (APT) is a PN method whereby healthcare professionals assess sex partners, by telephone consultation, before giving the index patient antibiotics and STI self-sampling kits to deliver to their sex partner(s). The Limiting Undetected Sexually Transmitted infections to RedUce Morbidity programme aims to determine the effectiveness of APT in heterosexual women and men with chlamydia and determine whether APT could affectChlamydia trachomatistransmission at population level.Methods and analysisThis protocol describes a cross-over cluster randomised controlled trial of APT, offered as an additional PN method, compared with standard PN. The trial is accompanied by an economic evaluation, transmission dynamic modelling and a qualitative process evaluation involving patients, partners and healthcare professionals. Clusters are 17 sexual health clinics in areas of England and Scotland with contrasting patient demographics. We will recruit 5440 heterosexual women and men with chlamydia, aged ≥16 years.The primary outcome is the proportion of index patients testing positive forC. trachomatis12-16 weeks after the PN consultation. Secondary outcomes include: proportion of sex partners treated; cost effectiveness; model-predicted chlamydia prevalence; experiences of APT.The primary outcome analysis will be by intention-to-treat, fitting random effects logistic regression models that account for clustering of index patients within clinics and trial periods. The transmission dynamic model will be used to predict change in chlamydia prevalence following APT. The economic evaluation will use mathematical modelling outputs, taking a health service perspective. Qualitative data will be analysed using interpretative phenomenological analysis and framework analysis.Ethics and disseminationThis protocol received ethical approval from London—Chelsea Research Ethics Committee (18/LO/0773). Findings will be published with open access licences.Trial registration numberISRCTN15996256.
Assessing the European impact of alcohol misuse and illicit drug dependence research: clinical practice guidelines and evidence-base policy
Authors: Pallari Elena , Soukup Tayana , Kyriacou Andri , Lewison Grant 
Published: March 2020

BackgroundDespite alcohol and illicit drug dependence being one of the most common diagnoses in Europe, there is heterogeneity of research evidence used in policy and practice.ObjectiveWe sought to (1) evaluate European research outputs on alcohol misuse and drug addiction in 2002–2018 in the Web of Science, (2) compare these with their burden of disease and (3) determine their impact in several ways.MethodsA bibliometric research was undertaken including an assessment of the citation counts, the influence of research on members of national health advisory committees, and their contribution to the evidence base of clinical practice guidelines (CPGs).FindingsThere were 3201 analysed references cited in 28 CPGs across 11 European Countries on alcohol misuse and illicit drug abuse. Research conducted in the USA dominated both sets of CPGs, while many European countries were overcited relative to their research presence. The illicit drug research appeared to be adequate relative to the evidence of harm in Europe. However, alcohol misuse research appeared grossly inadequate to the harm it causes by a factor of 20.ConclusionsThe volume of research on illicit drug addiction is commensurate to the European burden, whereas alcohol misuse is far below what is needed to curb a significant source of harm.Clinical implicationsThe research asymmetries call for attention to the causes of the problem. Development of research-based solutions to a serious social harm is needed, including minimum pricing and collaborative work to harmonise efforts on disease management and treatment practices across European countries.
Estimating the burden of road traffic crashes in Uganda using police and health sector data sources
Authors: Muni Kennedy Maring , Ningwa Albert , Osuret Jimmy , Zziwa Esther Bayiga , Namatovu Stellah , Biribawa Claire , Nakafeero Mary , Mutto Milton , Guwatudde David , Kyamanywa Patrick , Kobusingye Olive 
Published: March 2020

BackgroundIn many low-income countries, estimates of road injury burden are derived from police reports, and may not represent the complete picture of the burden in these countries. As a result, WHO and the Global Burden of Diseases, Injuries and Risk Factors Project often use complex models to generate country-specific estimates. Although such estimates inform prevention targets, they may be limited by the incompleteness of the data and the assumptions used in the models. In this cross-sectional study, we provide an alternative approach to estimating road traffic injury burden for Uganda for the year 2016 using data from multiple data sources (the police, health facilities and mortuaries).MethodsA digitised data collection tool was used to extract crash and injury information from files in 32 police stations, 31 health facilities and 4 mortuaries in Uganda. We estimated crash and injury burden using weights generated as inverse of the product of the probabilities of selection of police regions and stations.ResultsWe estimated that 25 729 crashes occurred on Ugandan roads in 2016, involving 59 077 individuals with 7558 fatalities. This is more than twice the number of fatalities reported by the police for 2016 (3502) but lower than the estimate from the 2018 Global Status Report (12 036). Pedestrians accounted for the greatest proportion of the fatalities 2455 (32.5%), followed by motorcyclists 1357 (18%).ConclusionsUsing both police and health sector data gives more robust estimates for the road traffic burden in Uganda than using either source alone.
Supervised pulmonary tele-rehabilitation versus pulmonary rehabilitation in severe COPD: a randomised multicentre trial
Authors: Hansen Henrik , Bieler Theresa , Beyer Nina , Kallemose Thomas , Wilcke Jon Torgny , Østergaard Lisbeth Marie , Frost Andeassen Helle , Martinez Gerd , Lavesen Marie , Frølich Anne , Godtfredsen Nina Skavlan 
Published: March 2020

RationalePulmonary rehabilitation (PR) is an effective, key standard treatment for people with COPD. Nevertheless, low participant uptake, insufficient attendance and high drop-out rates are reported. Investigation is warranted of the benefits achieved through alternative approaches, such as pulmonary tele-rehabilitation (PTR).ObjectiveTo investigate whether PTR is superior to conventional PR on 6 min walk distance (6MWD) and secondarily on respiratory symptoms, quality of life, physical activity and lower limb muscle function in patients with COPD and FEV1<50% eligible for routine hospital-based, outpatient PR.MethodsIn this single-blinded, multicentre, superiority randomised controlled trial, patients were assigned 1:1 to 10 weeks of groups-based PTR (60 min, three times weekly) or conventional PR (90 min, two times weekly). Assessments were performed by blinded assessors at baseline, end of intervention and at 22 weeks’ follow-up from baseline. The primary analysis was based on the intention-to-treat principle.Measurements and main resultsThe primary outcome was change in 6MWD from baseline to 10 weeks; 134 participants (74 females, mean±SD age 68±9 years, FEV133%±9% predicted, 6MWD 327±103 metres) were included and randomised. The analysis showed no between-group differences for changes in 6MWD after intervention (9.2 metres (95% CI: −6.6 to 24.9)) or at 22 weeks’ follow-up (−5.3 metres (95% CI: −28.9 to 18.3)). More participants completed the PTR intervention (n=57) than conventional PR (n=43) (χ2test p<0.01).ConclusionPTR was not superior to conventional PR on the 6MWD and we found no differences between groups. As more participants completed PTR, supervised PTR would be relevant to compare with conventional PR in a non-inferiority design.Trial registration numberClinicalTrials.gov (NCT02667171), 28 January 2016.