bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOPAMINERGIC SYSTEM: STRESS, DEPRESSION AND CANCER (PART 2)
Authors: Bocharova O. A. , Bocharov E. V. , Kucheryanu V. G. , Karpova R. V. , Vershinskaya A. A. 
Published: December 2019

In today’s world, we are constantly exposed to stress. At the same time, if acute stress can have a positive effect on the body, constant stress usually harms health, leading to serious diseases, including cancer, which is considered to be age-related disease. It is also known that stress can significantly deteriorate the efficacy of chemotherapies and anti-tumour immune response, promote tumor growth and metastasis spreading. Meanwhile dopamin known to be antiaging and antistress agent is able to inhibit tumourgenesis. Therefore the role of Central neuronal processes involving the dopaminergic system in the mechanisms of malignant growth control is discussed in the present review.
NON-CANONICAL ACTIVITY OF RETINOIC ACID AS A POSSIBLE MECHANISM OF RETINOID RESISTANCE IN CANCER THERAPY
Authors: Enikeev A. D. , Komelkov A. V. , Akselrod M. E. , Tchevkina E. M. 
Published: December 2019

Retinoic acid (RA) is one of the most functionally active intracellular metabolites of vitamin A, regulating the key physiological processes, including the differentiation of cells, organs and tissues. RA is successfully applied in the treatment of acute promyelocytic leukemia. Drugs based on RA and other natural and synthetic retinoids are being actively developed for the treatment of other oncopathologies, including various solid tumors. However, the use of RA in the treatment of malignant tumors is restricted by the rapid acquisition of RA-resistance. The mechanisms of RA-resistance formation are still poorly understood, what could be explained apparently by the large number of genes directly or indirectly being regulated by RA at transcription level, including genes regulating the activity and metabolism of RA itself. The situation is further complicated by the relatively recently discovered non-genomic or non-canonical activity of RA, which consists in the non-transcriptional regulation of key protein kinases involved in tumor progression. The review is devoted to the analysis of published data on non-canonical activity of RA. The review provides a modern view on the main mechanisms implementing the canonical genomic activity of the RA, presents available information on the RA-dependent non-transcriptional regulation of ERK1 / 2, PI3K / AKT, p38MAPK and PKC protein kinases and possible mechanisms mediating this activity as well as potential significance of the RA-dependent activation of intracellular signaling pathways in the formation of RA-resistance and the malignant potential of transformed cells.
EXPERIMENTAL IMMUNOTHERAPY MODEL OF RETINOBLASTOMA
Authors: Ushakova T. L. , Dolgopolov I. S. , Sokolova Z. A. , Chkadua G. Z. , Titov N. S. , Bukreev Yu. M. , Serov Yu. A. , Gorovtsova O. V. , Buletov D. A. , Kozlov N. A. , Polyakov V. G. 
Published: December 2019

Introduction. The main reason for enucleation of the eye when attempting organ-preserving treatment are intraocular tumors that do not respond well to chemotherapy.Purpose. The aim of the study was to find new effective and safe organ-preserving methods of treatment of intraocular refractory and recurrent retinoblastoma (RB).Materials and methods. The study included female chinchilla rabbits. The cell line of human RB was intravitreally inserted into the right eye of each animal. The left eye was a control. After obtaining a stable intraocular growth of RB and prolongation of the growth of RB, human cytotoxic lymphocytes (CTL) were intravitreally injected into the affected and control eye K1 at a concentration of 1 × 106 in 0.1 ml suspension and K2 – 5 × 106 in 0.1 ml, respectively.Results. Histological examination of the removed right eyes in animals confirmed the presence of nodal growth of malignant small-cell tumor on the border of the vascular and retinal membranes (epicenter in the choroid) on the posterior wall of the eye. There was scant lymphoid infiltration, without signs of therapeutic pathomorphosis. In the removed animal»s left eyes there is a preservation of histological structures of the eyeball, without dystrophic changes in the cells of the retina and vascular membranes. In the area of limb unit microcap lymphohistiocytic infiltration (with no elements of the tumor). In the choroid single scattered lymphocytes.Conclusion. A short period of observation of the tumor did not allow conclusions about the effectiveness of CTL, but the concentrations of CTL used in the experiment did not lead to dystrophic changes in retinal cells and the choroid of the eye, which is an important factor in overcoming the toxicity of the proposed adoptive immunotherapy. At the next stage of the experiment, in our opinion, it is necessary to study in more detail the cytotoxic effect on healthy structures of the eye and the effectiveness of CTL in a larger number of affected rabbit eyes, using their different concentrations and multiplicity of administration.
LANDSLIDE SUSCEPTIBILITY ASSESSMENT AROUND BABADAĞ (DENİZLİ) TOWN USING LOGISTIC REGRESSION METHOD
Authors: ÇAN Tolga , TEKİN Senem 
Published: December 2019

In this study landslide susceptibility assessments
were evaluated using logistic regression method around the Babadağ town
extending to 1133 km2. Almost 300 slide type landslides
corresponding 44km2 were identified in the area. Some of the residential areas, agricultural
lands and lifeline systems has been severely damaged by landslides and more
than five hundreds dwellings were evacuated in the region. Among the landslide
conditioning factors; elevation, slope, plan and profile curvatures, proximity
to faults and rivers and geological maps have been prepared in Geographical
Information Systems environment with spatial resolution of 25 m The
performance of the susceptibility map when compared to the landslide inventory
revealed that high and very high susceptible zones correspond to 23 % of
the study area including 72.13% of the recorded landslides.
BENDING STRENGTH AND STRUCTURAL HEALING PROPERTIES OF CARBON/PP(POLYPROPYLENE)/EPOXY COMPOSITES
Authors: KAYA Gaye , ÇAM Pınar 
Published: December 2019

Bending strength and structural healing properties of
carbon/PP(Polypropylene)/epoxy hybrid composites are investigated. Carbon and
PP fibres are woven in a manual loom in which the carbon fibres provide high
strength while the PP fibres contribute with their high strain in
hybridization. Two different structural
healing processes are used. Effectiveness of the proposed healing processes is
evaluated by both mechanically and microscopically. The results showed that
bending strengths of healed composites incredibly decreased at both 0° and 90° directions.
Residual bending strengths of press-healed composites are higher than that of
oven-healed composites since the molten PP filled the gaps more influentially
under pressure.
Семиотический подход в биоэтике: от морального кодекса читателя к этике чистого листа
Authors: Попова Ольга Владимировна 
Published: December 2019

<p>Целью статьи является исследование возможностей использования эвристических ресурсов семиотики в современном биоэтическом дискурсе. Опираясь на идеи классиков семиотики Ч. С. Пирса, В. леди Уэлби, У. Эко автор обращает внимание на концепт знака как этически релевантного объекта. В процессе исследования демонстрируется необходимость поиска «семантических универсалий» (понятие У. Эко), которые должны были бы обеспечить универсальные соматические (телесные) права человека. По мнению автора, данные универсалии являются фундирующими для биоэтического дискурса и, в целом, являются необходимыми для перевода динамики науки «в интеллектуальное и моральное русло» (В. Уэлби).</p><p>На основе использования результатов исследований отечественных философов (Б. Г. Юдина, П. Д. Тищенко, И. В. Мелик-Гайказян и др.) артикулирован ряд проблем биоэтики, позволяющих оценить релевантность семантического подхода для формирования биоэтического знания. Показано, что языковые игры с именованием и манипулированием знаками, представляющие реализацию лингвистического модуса конструирования человека, зачастую направлены на осуществление тех или иных прагматических биомедицинских целей, которые соответствуют познавательным интенциям ученого, например, связанным с проведением успешного биомедицинского эксперимента. При переходе в рассуждениях о человеке от персонально ориентированного дискурса к дискурсам о «вещах», «артефактах», «объектах опыта» и т. д. дискурсивное пространство может использоваться как инструмент легитимации каких-либо действий по отношению к человеческому существу.</p><p>Сделан вывод о том, что среди существующих стратегий толкования человеческого существования (в контексте распространяющихся тенденций генетического и нейронаучного редукционизма) необходимо отстаивать нередукционистскую герменевтику человека и сопряженную с нею «этику чистого листа» (понятие О. В. Поповой).</p>
Why a multidisciplinary agenda for Southern Europe?
Authors: De Noronha Teresa , Vaz Eric 
Published: December 2019

Since the process of southern Europe's integration in the European Union, the Mediterranean region has seen a more considerable gap between central and northern European countries and its southern European counterpart. Thus, in a European context of social cohesion, it becomes necessary to better understand Southern Europe, without escaping to the so required perception of the complexity of Mediterranean culture. As a significant player along history, Southern Europe established a platform of diversity and freedom consistently, bringing peace between different historic-cultural traditions. Moreover, the southern frontier of Europe to Africa and Asia has become a crucial determinant in the current times of change where ruptures in the political systems are also defining new patterns of regional migration. Meanwhile, the integration of Italy, Portugal, Spain, and Greece in the European Union reinforced an essential search for stability, altering to some extent the political and economic predispositions of these countries. This has been followed by somewhat rigid institutions, that remain, to a certain extent, an obstacle to sustainable development, and justify a broader assessment of the potential of policy and governance intervention. A Mediterranean region where a context of stagnation or increasing poverty and migration is leading most impoverished areas to a deleterious deprivation of human resources and capital. In such cases towards conflict, Southern European countries may represent a bridging alternative and an exemplar representation of democracy. A co-joint positive Mediterranean agenda is necessary, where migration patterns become a substantial factor in the future of all the frontier countries: Italy and Greece, Spain, and Portugal. This special issue collects recent insights in socio-economic developments in Mediterranean countries in order to further a future agenda for Southern Europe.
Birth order is associated with caries development in young children: a register-based cohort study
Authors: Julihn Annika , Soares Fernanda Cunha , Hammarfjord Ulrika , Hjern Anders , Dahllöf Göran 
Published: December 2019

Abstract
Background: Birth order has been shown to affect the health of the child; less is known, however, about how birth order affects caries development in children. Thus, the present study investigated the association between birth order and dental caries development in young children.

Methods: This retrospective registry-based cohort study included all children born in 2000–2003 who were residing in Stockholm County, Sweden, at age 3 years (n = 83,147). The study followed the cohort until subjects reached 7 years of age. Children with registry data on dental examinations and sociodemographic characteristics at ages 3- and 7 years constituted the final study cohort (n = 65,259). The outcome variable was “caries increment from age 3- to 7 years” (Δdeft > 0) and the key exposure, “birth order”, was divided into five groups. A forward stepwise logistic binary regression was done for the multivariate analysis with adjustments for sociodemographic factors.

Results: At age 3 years, 94% had no fillings or manifest caries lesions. During the study period, 22.5% (n = 14,711) developed dental caries. The final logistic regression analysis found a statistically significant positive association between birth order and caries increment. Further, excess risk increased with higher birth order; with the mother’s first-born child as reference, risk for the second-born child was OR 1.17, 95% CI=1.12–1.23; for the third-born child, OR 1.47, 95% CI=1.38–1.56; for the fourth-born child, OR 1.69, 95% CI=1.52–1.88; and for the fifth-born or higher birth-order child, OR 1.84, 95% CI=1.58–2.14.

Conclusions: These findings show that birth order influences caries development in siblings, suggesting that birth order can be regarded as a predictor for caries development in young children. This factor may be helpful in assessing caries risk in preschool children and should be considered in caries prevention work in young children with older siblings.
Remuneration systems of community health workers in India and promoted maternal health outcomes: a cross-sectional study
Authors: Koehn Hannah , Zheng Shenglin , Houser Robert F. , O’Hara Corey , Rogers Beatrice Lorge 
Published: December 2019

Abstract
Background: This study assessed the association of remuneration systems of paid-for-performance Accredited Social Health Activists (ASHAs) and salaried Anganwadi workers (AWWs) on seven maternal health outcomes in four states in India: Andhra Pradesh (AP), Chhattisgarh, Odisha (Orissa), and Uttar Pradesh (UP). Methods: The cross-sectional study surveyed mothers of children aged 6-23 months. A total of 3,455 mothers were selected via multistage cluster sampling. The seven health outcomes related to the community health worker (CHW) visits were: institutional delivery, complete immunization, exclusive breastfeeding for six months, timely introduction of complementary feeding, continued breastfeeding during child’s illness, handwashing, and awareness of Nutrition and Health Days (NHDs). Results: The results varied by state. Mothers who received ASHA visits were significantly less likely to have an institutional delivery, timely introduction of complementary feeding, awareness of Nutrition and Health Days (NHDs), proper handwashing, and exclusive breastfeeding for the first six months in at least one of the four states. Conversely, AWW’s home visits were positively predictive of the following health outcomes in certain states: complete immunization for index child, continued breastfeeding during the child’s illness, handwashing, and awareness of NHDs. Conclusions: ASHAs’ home visits were not more strongly associated with health outcomes for which they were paid than outcomes for which they were unpaid. AWWs’ home visits were positively associated with awareness of NHDs, and associations varied for other recommended health behaviors. Further research could elucidate the causes for successes and failures of CHW programs in different states of India.
Impact of Hemodialysis and Post-Dialysis Period on Granular Activity Levels
Authors: Larkin John W , Han Maggie , Han Hao , Guedes Murilo H , Gonçalves Priscila Bezerra , Poli-de-Figueiredo Carlos Eduardo , Cuvello-Neto Américo Lourenço , Barra Ana Beatriz L , de Moraes Thyago Proença , Usvyat Len A , Kotanko Peter , Canziani Maria Eugenia F , Raimann Jochen G , Pecoits-Filho Roberto 
Published: December 2019

Abstract
Background Physical activity (PA) is typically lower on hemodialysis (HD) days. Albeit intradialytic inactivity is expected, it is unknown whether recovery after HD contributes to low PA. We investigated the impact of HD and post-HD period on granular PA relative to HD timing.Methods We used baseline data from the HDFIT trial conducted from August 2016 to October 2017. Accelerometry measured PA over one week in patients who received thrice-weekly high-flux HD (vintage 3 to 24 months), were clinically stable, and had no ambulatory limitations. PA was assessed on HD days (0 to ≤24 hours after start HD), first non-HD days (>24 to ≤48 hours after start HD) and second non-HD day (>48 to ≤72 hours after start HD). PA was recorded in blocks/slices: 4 hours during HD, 0 to ≤2 hours post-HD (30 minute slices), and >2 to ≤20 hours post-HD (4.5 hour slices). Blocks/slices of PA were captured at concurrent/parallel times on first/second non-HD days compared to HD days.Results Among 195 patients (mean age 53±15 years, 71% male), step counts per 24-hours were 3919±2899 on HD days, 5308±3131 on first non-HD days (p<0.001), and 4926±3413 on second non-HD days (p=0.032). During concurrent/parallel times to HD on first and second non-HD days, patients took 1308 and 1128 more steps (both p<0.001). Patients took 276 more steps and had highest rates of steps/hour 2-hours post-HD versus same times on first non-HD days (all p<0.05). Consistent findings were observed on second non-HD days.Conclusions PA was higher within 2-hours of HD versus same times on non-HD days. Lower PA on HD days was attributable to intradialytic inactivity. The established PA profiles are of importance to the design and development of exercise programs that aim to increase activity during and between HD treatments.
Luteal blood flow as a predictive factor for methotrexate treatment outcome in women with unruptured tubal pregnancy
Authors: Wang Li , Pei Meili , Yang Ting , Zhao Juan , Yang Xiaofeng 
Published: December 2019

Abstract
Background Blood flow in the corpus luteum is associated with luteal function. However, the impact of luteal blood flow on the Methotrexate(MTX) treatment in women with unruptured tubal pregnancy has not been reported. The aim of the present study was to observe the impact of luteal blood flow on therapeutic effect of MTX in women with unruptured tubal pregnancy.Methods A prospective study recruited 129 women with unruptured tubal pregnancy in the First Affiliated Hospital of Xi’an Jiaotong University from September 2016 to June 2018. One hundred and fifteen participants were treated successfully with MTX, and women were divided into 2 groups according to the luteal blood flow, included poor luteal blood flow group and rich luteal blood flow group. The therapeutic effect were compared between the two groups.Results Women in rich luteal blood flow group had a significantly higher serum β-human chorionic gonadotropin(β-hCG) level 4 days,1 week and 2 weeks after MTX treatment compared with women in poor luteal blood flow group( P <0.05).The average diameter of ectopic mass 1 week,2 weeks and 3 weeks after MTX treatment in women with rich luteal blood flow were significantly bigger( P <0.05),and the time of serum β-hCG clearance and ectopic mass disappearance were significantly longer compared with women in poor luteal blood flow group( P <0.05).Conclusions Luteal blood flow might be as a predictive factor for MTX treatment outcome in women with unruptured tubal pregnancy, and those with rich luteal blood flow needed longer recovery time.
Antimicrobial and Antibiofilm Potency of Green Silver Nanoparticles Synthesized by Aqueous Garlic Extract Against Microbes Causing Otitis Media
Authors: Mustafa Eman A. , Hashem Abd El Gawad , Elhifnawi Hala N. , Nada Hanady G. , Khattab Rania A. 
Published: December 2019

Abstract
Aim of study: Otitis media (OM) is highly prevalent worldwide and is the main cause of hearing loss in developing countries. Resistant microorganisms and biofilm formation have become a major health and economic problem. The aim of this study was to establish an eco-friendly method for synthesis of silver nanoparticles using aqueous garlic extract and sunlight. Moreover, detect its potential to inhibit otitis media microbes.Methods: Basically, highly resistant and biofilm forming otitis media pathogenic isolates were determined by Kirby-Bauer disc diffusion method and their biofilm production qualitatively was tested. Then, compared their susceptibility to tetracyclin 30µg (for bacteria) and nystatin 100 µg (for fungi) alone and with different concentrations of green synthesized silver nanoparticles (AgNPs), as well as, their biofilm production. AgNPs were prepared by easy, fast, non-toxic, economically eco-friendly way, using the direct sunlight irradiation on aqueous garlic extract. Their characterization by UV- visible spectral analysis, TEM, DLS, XRD and FTIR were studied. Results: Two multidrug resistant bacterial isolates; Pseudomonas aeruginosa and Bacillus cereus were detected as biofilm producers with black colonies on congo-red agar and three resistant fungal isolates to nystatin; Penicillium chrysogenum, Aspergillus niger and Aspergillus flavus were tested against green synthesized AgNPs. Highly significant (p-value<0.001) antimicrobial and antibiofilm activity of biosynthesized AgNPs against tested pathogens were illustrated in this study. TEM images for Pseudomonas aeruginosa and Aspergillus flavus after treated with AgNPs, were exhibited shrinkage in the cytoplasmic materials, rupture of cell walls, precipitation of AgNPs particles inside the cells and biofilm was mostly disseminated.Conclusion: aqueous garlic extract that used to stabilize the AgNPs may be ideal natural candidates for future studies exploring their safely use in biomedical applications especially against the repeated infections caused by multi drug resistant (MDR) and biofilm forming microbials as in otitis media.
Antiphospholipid syndrome may induce non-thrombus internal jugular vein stenosis - Two cases report and literature review
Authors: Si-ying Song , Gary Rajah , Yu-chuan Ding , Xun-ming Ji , Meng Ran 
Published: December 2019

Abstract
Background: Antiphospholipid syndrome (APS) is associated with artery or venous thrombosis. However, non-thrombus venous stenosis is rarely reported.Case presentation: This study described two young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literatures on this issue, including clinical features, diagnosis and treatment.Conclusions: IJVS is a rather rare complication of APS. This is first report of non-thrombus venous stenosis resulted from aPL mediated vessel wall damage. High titer of aPL could induce stenosis without thrombosis formation due to long-term standardized anticoagulation. Follow-up of autoantibodies are necessary to be done dynamically. Treatment for patients with IJVS of autoimmune etiology should be concomitant use of anticoagulants and steroids.