bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Conditions and Procedure for the Admission of Children of Incarcerated Mothers to Mother-and-Baby Units at Prisons in Poland
Authors: Teleszewska Magdalena 
Published: February 2020

The admission of mother and child to the a mother-and-baby unit has a positive effect on both the development of the child as well as the social rehabilitation of the mother. Children in mother-and-baby units are provided the right conditions for development. The mother learns to fulfill her parental responsibilities. In addition, incarcerated women who are in prison with their children want to change for the better, in order to provide their children a better future.
Reticulated platelets – clinical application and future perspectives
Authors: Meintker Lisa , Krause Stefan W. 
Published: February 2020

Abstract
Reticulated platelets are immature platelets freshly released from the bone marrow into the circulation and contain vestigial amounts of ribonucleic acid. Thus, they can serve as an indicator for the activity of thrombopoiesis. Despite the current lack of a standardized reference method, two types of hematology analyzers have incorporated a fully automated measurement of reticulated platelets. The “immature platelet fraction” (IPF; Sysmex XE-/XN-series) has some clinical utility in the differential diagnosis of thrombocytopenia. This is less clear for “reticulated platelets” (retPLT; Abbott CELL-DYN Sapphire/Alinity HQ). The usefulness of these parameters in the prediction of platelet recovery after chemotherapy or stem cell transplantation and as a decision aid for platelet transfusions has not been unequivocally confirmed. Recent findings have shown an association of reticulated platelets with an adverse risk in patients with coronary artery disease and stroke as well as resistance to anti-platelet therapy. Furthermore, a role of reticulated platelets for the prediction of sepsis was indicated. However, validation in larger prospective trials is necessary to establish the clinical benefit of reticulated platelets in these conditions. This review gives an overview of the available analytical methods and summarizes the current knowledge regarding the clinical application of reticulated platelets.
Preparation of CaCO3nanoparticle/pulp fiber composites using ultrafine bubbles
Authors: Fuchise-Fukuoka Moe , Oishi Masatoshi , Goto Shisei , Isogai Akira 
Published: February 2020

AbstractIn this study, CaCO3nanoparticle/pulp fiber composites were prepared by formation of ultrafine bubbles of CO2gas in aqueous Ca(OH)2solution containing beaten or unbeaten pulp fibers. Scanning electron microscopy images of the fiber/CaCO3composites showed that primary CaCO3nanoparticles with average diameters of 50–80 nm densely formed on the pulp fiber surfaces. The average sizes and morphologies of the precipitated CaCO3nanoparticles can be controlled by controlling the CO2flow rate into the pulp slurry. From dynamic drainage analysis of the CaCO3/pulp slurries with high shear force, retention of the CaCO3nanoparticles on the pulp fiber mats was ∼10 % higher for the slurry formed by the ultrafine bubble method than for that formed by mixing precipitated CaCO3and pulp fiber. Therefore, precipitated CaCO3nanoparticles stably formed on the pulp fiber surfaces in the slurry by the ultrafine bubble method. Compared with reference handsheets, handsheets prepared with the CaCO3nanoparticle/pulp fiber composites had higher CaCO3contents and had consequently higher specific surface areas and surface smoothness values. In contrast, the tensile strength and elongation at break decreased because the sheet density decreased with increasing CaCO3content in the handsheets.
Controlling Risks in the Compounding Process of Individually Formulated Parenteral Nutrition: Use of the FMECA Method (Failure modes, effects, and Criticality Analysis)
Authors: Royer Mathilde , Libessart Maïté , Dubaele Jean-Marc , Tourneux Pierre , Marçon Fréderic 
Published: February 2020

AbstractParenteral nutrition (PN) in the neonatal intensive care unit (NICU) involves a succession of risky processes. The objective was to identify and prioritize the risks associated with PN in order to improve the quality of the pathway. A failure modes, effects, and criticality analysis (FMECA) was used to identify potential PN pathway failure modes. A multidisciplinary working group conducted a functional analysis of the processes, then listed the failure modes (FM). The FM criticality was assessed on a scale from 1 to 5 for occurrence (O), severity (S), and detection (D). The risk priority number (RPN), ranging from 1 to 125, was calculated. The FMECA identified 99 FM (prescription (n=28), preparation (n=48), and administration (n=23)). The median RPN was 12, with scores ranging from 3 to 48. 25 % of the scores had an RPN>21.75.Among them, 12 were associated with prescription FM, 5 were associated with FM related to preparation and 8 were associated with a FM linked to administration. It allowed us to prioritize areas of potential quality improvement for parenteral nutrition of the preterm infant. The results demonstrated the need for the presence of a clinical pharmacist in the NICU to ensure the quality of PN process.
Promoting ‘Positive Stories’ of Help and Rescue from the 1992-1995 War in Bosnia and Herzegovina. An Alternative to the Dichotomy of Guilt and Victimhood?
Authors: Moll Nicolas 
Published: February 2020

AbstractPublic discourses about wars and mass violence are often dominated by questions of guilt and victimhood as well as a focus on the figures of ‘perpetrators’ and ‘victims’. This can also be observed concerning the public remembrance of the 1992-1995 conflict in Bosnia-Herzegovina. However, attempts were made here to promote the memory of another war-related figure: that of the rescuer who helped people ‘from the other side’. The author analyses these attempts at remembrance in Bosnia-Herzegovina, and places them within the context of global efforts to publicly acknowledge rescuers, in particular the ‘Righteous Among the Nations’.
The New Independent Orthodox Church in Ukraine
Authors: Mykhaleyko Andriy 
Published: February 2020

AbstractIn January 2019, the Ukrainian Orthodoxy received what is known as the tomos from the Ecumenical Patriarchate of Constantinople, which established the independent Orthodox Church in Ukraine. The granting of autocephaly to the Orthodox Christians of Ukraine caused a deep crisis in the Orthodoxy and a conflict between Constantinople and Moscow. The Russian Orthodox Church (ROC) condemned the Ecumenical Patriarch’s action and accused the Patriarchate of Constantinople of encroaching on the ‘canonical territory’ of the ROC. The author examines the foundations of this formation of a new Orthodox Church, the religious and political factors influencing the process of its establishment, and the reaction of the Russian Orthodox Church leadership and Russian politicians. He also reflects on the consequences for relations within Orthodoxy, for ecumenical dialogue, and for contacts between Ukraine and Russia.
In vitro antioxidant, anti-inflammatory and anti-cancer activities of methanolic extract of Asparagus horridus grows in North Cyprus Kuzey Kıbrıs da yetişen Asparagus horridus metanolik ekstraktının in-vitro antioksidan, anti-enflamatuar ve anti-kanser aktivitesi
Authors: Altundag Ergul Mutlu , Gençalp Duygu , Özbilenler Cahit , Toprak Kübra , Kerküklü Namık 
Published: February 2020

Abstract

Background

Asparagus horridus is an edible plant known as “Ayrelli” in North Cyprus. The scientific literature has not yet submitted a report about the antioxidant, anti-inflammatory and anti-cancer activities of A. horridus plant from North Cyprus until now. The purpose of the research was to determine the antioxidant, anti-inflammatory and anti-cancer activities of A. horridus.

Materials and methods
Soxhlet extraction of A. horridus was performed using methanol. Antioxidant activity was determined by DPPH, TFC, FRAP and TPC assays. Protein-denaturation assay was performed to determine the anti-inflammatory effect. The anti-cancer effects of the extract on HepG2 and B-CPAP cell lines were determined with MTT assay.

Results
Antioxidant activity for A. horridus extract was determined by DPPH (50%), TFC (266.26 μg QUE/mg extract), FRAP (1.27 μg FeSO4/mg extract) and TPC (167.613 μg GAE/mg extract) assays at 25 mg/mL. Inhibition of protein-denaturation activity was found as 29.42% at 25 mg/mL. After 24 h of the extract treatment, cell proliferation of HepG2 and B-CPAP cancer cells were inhibited at IC50 values 63.24 μg/mL and 101.24 μg/mL, respectively.

Conclusion
These results have shown that the methanol extract of A. horridus grows in North Cyprus has antioxidant, anti-inflammatory and anti-cancer activities.
Utilization of 1-phenylimidazo[1,5-a]quinoline as partner in 1,4-dipolar cycloaddition reactions
Authors: Jaber Areej M. , Zahra Jalal A. , El-Abadelah Mustafa M. , Sabri Salim S. , Khanfar Monther A. , Voelter Wolfgang 
Published: February 2020

Abstract
A Selected set of 2-(quinolin-2-yl)-1,3-oxazepino[7,6-b]indoles 4a–d and dihydroacenaphtho[1,2-f][1,3]oxazepine 5 have been prepared via 1,4-dipolar cycloaddition reaction involving 1-phenylimidazo[1,5-a]quinoline, dimethyl acetylenedicarboxylate, and N-(substituted)isatins or acenaphthoquinone. Structures of the new heterocycles 4a–d and 5 are supported by NMR and HRMS spectral data, and confirmed by single-crystal X-ray crystallography for 4c and 5.
The Impact of Thwarted Belonging on Tolerance of Abusive Behaviors in a Romantic Relationship
Authors: Trujillo Alejandro , Claypool Heather M. 
Published: February 2020

Introduction: This work examined the role of thwarted belonging in directing reactions to intimate partner violence (IPV). We tested two competing hypotheses. First, we offered the Insensitivity Hypothesis, which argued that excluded (compared to control) participants would indicate they were comfortable and willing to remain in an abusive relationship longer, an effect likely mediated by reduced relational needs. Second, we offered the Hypersensitivity Hypothesis, which argued that excluded (compared to control) participants would indicate they were uncomfortable and willing to leave an abusive relationship earlier, an effect likely mediated by activation of hostile cognitions. Methods: To test these, female participants underwent an exclusion or non-exclusion experience, completed measures of the hypothesized mediators, and then read a vignette describing a heterosexual romantic relationship that slowly turned more abusive. Participants took the perspective of the female victim and indicated when they would feel uncomfortable in the relationship and leave the relationship. Results: Results partially supported the Insensitivity Hypothesis, as exclusion (relative to control) lowered relational needs, and lowered relational needs predicted later desires to exit the relationship (no significant effects emerged for discomfort onset). Discussion: Implications of these findings for the belonging and IPV literatures are discussed.
Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain
Authors: Tewari Damini , Cook Andrew D. , Lee Ming-Chin , Christensen Anne D. , Croxford Andrew , Becher Burkhard , Poole Daniel , Rajasekhar Pradeep , Bunnett Nigel , Smith Julia E. , Hamilton John A. , McMahon Stephen B. 
Published: February 2020

The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent years. Whereas the role played by cytokines as neuronal mediators is no longer contested, the mechanisms by which cytokines modulate pain processing remain to be elucidated. In this study, we have analyzed the involvement of granulocyte-macrophage colony stimulating factor (GM-CSF) in nociceptor activation in male and female mice. Previous studies have suggested GM-CSF might directly activate neurons. However, here we established the absence of a functional GM-CSF receptor in murine nociceptors, and suggest an indirect mechanism of action, via immune cells. We report that GM-CSF applied directly to magnetically purified nociceptors does not induce any transcriptional changes in nociceptive genes. In contrast, conditioned medium from GM-CSF-treated murine macrophages was able to drive nociceptor transcription. We also found that conditioned medium from nociceptors treated with the well established pain mediator, nerve growth factor, could also modify macrophage gene transcription, providing further evidence for a bidirectional crosstalk.SIGNIFICANCE STATEMENTThe interaction of the immune system and the nervous system is known to play an important role in the development and maintenance of chronic pain disorders. Elucidating the mechanisms of these interactions is an important step toward understanding, and therefore treating, chronic pain disorders. This study provides evidence for a two-way crosstalk between macrophages and nociceptors in the peripheral nervous system, which may contribute to the sensitization of nociceptors by cytokines in pain development.
Direct Activation of Primary Motor Cortex during Subthalamic But Not Pallidal Deep Brain Stimulation
Authors: Johnson Luke A. , Wang Jing , Nebeck Shane D. , Zhang Jianyu , Johnson Matthew D. , Vitek Jerrold L. 
Published: February 2020

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an effective treatment for parkinsonian motor signs. Though its therapeutic mechanisms remain unclear, it has been suggested that antidromic activation of the primary motor cortex (M1) plays a significant role in mediating its therapeutic effects. This study tested the hypothesis that antidromic activation of M1 is a prominent feature underlying the therapeutic effect of STN and GPi DBS. Single-unit activity in M1 was recorded using high-density microelectrode arrays in two parkinsonian nonhuman primates each implanted with DBS leads targeting the STN and GPi. Stimulation in each DBS target had similar therapeutic effects, however, antidromic activation of M1 was only observed during STN DBS. Although both animals undergoing STN DBS had similar beneficial effects, the proportion of antidromic-classified cells in each differed, 30 versus 6%. Over 4 h of continuous STN DBS, antidromic activation became less robust, whereas therapeutic benefits were maintained. Although antidromic activation waned over time, synchronization of spontaneous spiking in M1 was significantly reduced throughout the 4 h. Although we cannot discount the potential therapeutic role of antidromic M1 activation at least in the acute phase of STN DBS, the difference in observed antidromic activation between animals, and target sites, raise questions about its hypothesized role as the primary mechanism underlying the therapeutic effect of DBS. These results lend further support that reductions in synchronization at the level of M1 are an important factor in the therapeutic effects of DBS.SIGNIFICANCE STATEMENTRecently there has been great interest and debate regarding the potential role of motor cortical activation in the therapeutic mechanisms of deep brain stimulation (DBS) for Parkinson's disease. In this study we used chronically implanted high density microelectrode arrays in primary motor cortex (M1) to record neuronal population responses in parkinsonian nonhuman primates during subthalamic nucleus (STN) DBS and globus pallidus internus (GPi) DBS. Our results suggest a contribution of antidromic activation of M1 during STN DBS in disrupting synchronization in cortical neuronal populations; however, diminishing antidromic activity over time, and differences in observed antidromic activation between animals and target sites with antidromic activation not observed during GPi DBS, raise questions about its role as the primary mechanism underlying the therapeutic effect of DBS.
Barreras para acceder a los servicios de rehabilitación de la baja visión: Una revisión de tema
Authors: Oviedo María Del Pilar 
Published: February 2020

Objetivo: Analizar las barreras reportadas en la literatura para el acceso a los servicios de rehabilitación de la baja visión.Materiales y métodos: Se realizó una revisión narrativa a partir de literatura científica publicada en el período 2008 a 2019 y vinculada en las bases de datos Pubmed, Scielo, Ebsco y Science Direct.Resultados: Las barreras reportadas por los prestadores de servicios de salud están relacionadas con la falta de conocimientos en baja visión y el escaso número de profesionales que se dedican a la atención así como la invisibilizacion de la misma en los planes de atención ocular. Las barreras manifestadas por las personas están relacionadas con la falta de información y conocimiento sobre los servicios de baja visión, dificultades para el desplazamiento/transporte y el temor a los estereotipos.Conclusiones: Las barreras para acceder a los servicios de rehabilitación son complejas, y algunas pueden abordarse más fácilmente que otras. Un aspecto clave para disminuir las barreras puede ser la mejora de la formación del recurso humano y la generación de canales de comunicación entre los profesionales y las personas. El estigma asociado a la discapacidad visual es un elemento que parece ser crucial y que debe abordarse.
Genetic Networks Underlying Natural Variation in Basal and Induced Activity Levels inDrosophila melanogaster
Authors: Watanabe Louis P , Gordon Cameron , Momeni Mina Y , Riddle Nicole C 
Published: February 2020

AbstractExercise is recommended by health professionals across the globe as part of a healthy lifestyle to prevent and/or treat the consequences of obesity. While overall, the health benefits of exercise and an active lifestyle are well understood, very little is known about how genetics impacts an individual’s inclination for and response to exercise. To address this knowledge gap, we investigated the genetic architecture underlying natural variation in activity levels in the model system Drosophila melanogaster. Activity levels were assayed in the Drosophila Genetics Reference Panel fly strains at baseline and in response to a gentle exercise treatment using the Rotational Exercise Quantification System. We found significant, sex-dependent variation in both activity measures and identified over 100 genes that contribute to basal and induced exercise activity levels. This gene set was enriched for genes with functions in the central nervous system and in neuromuscular junctions and included several candidate genes with known activity phenotypes such as flightlessness or uncoordinated movement. Interestingly, there were also several chromatin proteins among the candidate genes, two of which were validated and shown to impact activity levels. Thus, the study described here reveals the complex genetic architecture controlling basal and exercise-induced activity levels in D. melanogaster and provides a resource for exercise biologists.
Prediction of The Number of Ship Passengers in The Port of Makassar using ARIMAX Method in The Presence of Calender Variation
Authors: Farih Laili Nahlul , Fauziah Irma , Wijaya Madona Yunita 
Published: February 2020

AbstractIndonesia is an archipelago with the largest Muslim population in the world. Every year, Indonesian people have a tradition of meeting relatives in other areas or take a vacation on Eid al-Fitr. People use different modes of transport to travel such as air, water, and land transport. Port plays a role in supporting water transportation because it is a knot of inter-regional relations. The celebration of Eid al-Fitr moves forward by about 11 days every year. The purpose of this thesis is to make an estimate of the total departure of ship passengers in the main port of Makassar using the ARIMAX method with the effects of calendar variations. The ARIMAX method is a method that can be used when there are exogenous variables, where in this case the exogenous variable is in the form of variable dummy wich is Eid holidays. These forecasting results show that the ARIMAX method has a relatively small accuracy with the MAPE value of .Keywords: water transportation; calendar variations effects; Eid Al-Fitr. AbstrakIndonesia merupakan negara kepulauan dengan mayoritas muslim terbesar didunia. Setiap tahun masyarakat Indonesia memiliki tradisi bertemu sanak saudara di daerah lain ataupun berlibur pada hari raya Idul Fitri. Jalur transportasi yang digunakan yaitu melalui darat, udara dan laut. Pelabuhan memiliki peran yang sangat penting dalam mendukung transportasi laut karena menjadi titik simpul hubungan antar daerah. Perayaan hari raya Idul Fitri dalam setiap tahun mengalami pergeseran 11 hari. Tujuan penulisan skripsi ini adalah untuk membuat prakiraan total keberangkatan penumpang kapal di Pelabuhan Utama Makassar menggunakan metode ARIMAX dengan efek variasi kalender. Metode ARIMAX merupakan metode yang dapat digunakan ketika data tersebut menggunakan variable eksogen, dimana dalam kasus ini variable eksogennya berupa variable dummy libur hari raya idul fitri. Hasil peramalan ini menunjukan bahwa metode ARIMAX memiliki tingkat akurasi yang lebih baik dibandingkan ARIMA musiman dengan nilai MAPE sebesar 14,08%.Kata Kunci: transportasi air; efek variasi kalender, Hari Raya Idul Fitri.
PROKSİMAL HİPOSPADİASLI VE CİDDİ KORDİLİ ÇOCUKLARIN İKİ AŞAMALI AMELİYAT SONUÇLARININ HİPOSPADİAS OBJEKTİVE PENİL SKORLAMA (HOPS) İLE DEĞERLENDİRİLMESİ
Authors: BICAKCI Unal , ISSI Yaşar , YAĞIZ Beytullah , DEMİREL Berat Dilek 
Published: February 2020

AbstractPurposeSurgical
management for the severe proximal hypospadias remains controversial and it
might be challenging. In this study,we evaluated the surgical outcome of
patients with proximal hypospadias managed by two staged repair with dorsal
prepucial flaps.Patients and MethodsForty
one boys with proximal hypospadias are enrolled between
January 2006 and September 2016. The location of the urethral meatus was at the penoscrotal junction
(PSH), at the scrotum (SH) or at the perineum (PRH). First stage; chordee was
released and the prepucial flaps were constructed. Second stage; urethroplasty
was performed according to Thiersch-Duplay principle. We
assessed postoperative complication rates and utilized Hypospadias Objective
Penile Evaluation (HOPE) scoring to evaluate the cosmetic outcome.ResultsThere
are a total of 41 boys (31 PSH(%76), 3 SH(%7)
and 7 PRH(%17). The mean age at first operation
was 15±5,3 months. The
mean interval between the stages of the surgical procedures was
10.1±4.,9months.Sixteen patients had various enzyme deficiency or
dysgenesis. In two patients, diverticulum is developed after the repair.
stenosis has encountered in 10 patients
and fistula in 5. Two patients had dehiscence at glanular level. Relation did not demonstrated
between the severity of hypospadias and development of fistula,
stricture and diverticulum (p&gt;0,05). HOPE scores; 9,4 for the position of the meatus, 5,8
for shape of the meatus, 7,2 for shape of the glans penis, 9,3 for penile
torsion and 9,8 penile curvature. Conclusion

Incorporating
the dorsal prepucial skin flaps in
staged procedures has both satisfactory cosmetic and functional success
rates.