bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Sr Modifier on Microstructure and Mechanical Properties of ZL102 Casting Suspension Clamp
Authors: Fan Baozhen , Mo Juan , Zhang Jinghua , Shen Hongbing , Liu Rui 
Published: July 2020

Abstract
In this thesis, the microstructure and mechanical properties of the suspension clamp made of ZL102 material modified with different amounts of Sr added are studied, and the grip strength and damage load of the suspension clamp as well as the tensile testing properties at room temperature, hardness and impact toughness of the material are tested. The results show that with the increase of Sr addition, α solid solution gradually changes into dendrite, while coarse strip eutectic silicon and bulk primary crystal silicon gradually change into granular and short-rod shapes. With the addition of Sr modifier, the tensile strength, elongation, expansion and impact toughness of ZL102 material increased significantly, and the hardness value decreased slightly but with a smaller range. The grip strength test of suspension clamp modified with different added amounts of Sr meets the standard requirements, and the damage load test of suspension clamp modified without Sr does not meet the requirements. When the added amount of Sr is 0.0250%, the type test index of suspension clamp is stable and dispersive.
Discussion on deformation monitoring method of asphalt concrete core wall of high earth-rock dam
Authors: Hai-bo Cui , Bao-xin Liu , Chen-liang Zhang , Yong-hui Wang , Xiang Ji 
Published: July 2020

Abstract
The deformation of asphalt concrete core wall of earth rock dam is an important monitoring item of safety management in the construction and operation period of the project. This paper summarizes the conventional monitoring methods and principles of the deformation of asphalt concrete core wall, analyzes the application scope and existing problems of the conventional monitoring methods, and introduces a new method and principle of the deformation monitoring of asphalt concrete core wall of high earth rock dam, which effectively solves the problems The problems of conventional monitoring methods are solved, and the three-dimensional deformation monitoring of asphalt concrete core wall is realized.
Study on the Cleaning Device of Cement Silo Wall
Authors: Zhao Honghua , Hu Zhitong , Zhao Jian , Gong Xuyin , Han Qifei , Lin Yifei 
Published: July 2020

Abstract
The traditional way of cleaning the cement storehouse wall is manual storage, which is very dangerous. The collapse of the accumulated material causes casualties. In view of the current needs of cleaning, this paper designs a kind of machine which is suitable for the cleaning of domestic cement warehouse. The machine has the advantages of light weight, assembling and being suitable for any diameter warehouse. In this paper, the design scheme and mechanical structure of the machine are studied, and the working principle of the device is introduced. Finally, the static analysis of the finite element software is used to check the key parts and verify the correctness of the design scheme.
Experimental Study and Numerical Simulation Analysis of Geosynthetics Reinforced Bond Performance
Authors: Nan Yang 
Published: July 2020

Abstract
In the laboratory, the test of bond performance of civil composite reinforcement is usually carried out by consolidation drainage triaxial shear test, which involves three aspects: the stress, strength and volume change of cohesive soil. From the experimental results, it is not difficult to find that if researcher want to increase the volume stability of the high-pressure compaction soil, researcher need to increase the way of reinforcement, but through the way of reinforcement, the shear swelling body of the soil will be reduced, while the shear shrinkage body of the soil will not be reduced or increased. The test pieces used in the experiment are reinforced specimen and plain soil specimen. The biggest difference between them is the axial strain. When the axial strain is low, the reinforced specimen is lower than the strength of plain soil specimen, and the plain soil specimen is slowly higher than the reinforced specimen, which requires the axial strain to increase to a certain extent, which also has the phenomenon that the reinforcement delays the soil strength, which also depends on the number of reinforcement layers and tension of the reinforcement materials. With the increase of modulus of elongation, the phenomenon of delay will be more obvious. In the experiment, the peak strength of the soil is controlled by changing the number of layers of reinforcement and the tensile modulus of reinforcement. The experiment shows that with the increase of the number of layers of reinforcement, the peak strength of the soil is increased in a certain range, but once the peak value is exceeded, the peak strength of the soil will not be greatly changed by changing the number of layers of reinforcement, except by changing the number of reinforcement layers, the residual strength of soil can be controlled by changing the reinforcement material of tensile modulus, so that the stress-strain characteristics of soil will be greatly changed.
An ambipolar transistor based on a monolayer WS2 using lithium ions injection
Authors: Wang Heshen , Liu Qiye , Feng Xuemeng , Zhang Zhan , Wang Kai , Liu Zhaojun , Dai Jun-Feng 
Published: July 2020

Abstract
Ambipolar field-effect transistor (FET) devices based on two-dimensional (2D) materials have been attracted much attention due to potential applications in integrated circuits, flexible electronics and optical sensors. However, it is difficult to tune Fermi level between conduction and valence bands using a traditional SiO2 as dielectric layer. Here, we employed the lithium-ion conductive glass ceramic (LICGC) as the back-gate electrode in a monolayer WS2 FET. The effective accumulation and dissipation of Li+ ions in the interface induce a wide tune of Fermi level in the conducting channel by electron and hole doping, which show an ambipolar transport characteristics with threshold voltages at 0.9 V and −1.3 V, respectively. Our results provide an opportunity for fabricating ultra-thin ambipolar FET based on 2D materials.
Single-shot transverse coherence measurements with Young's double pinholes at FLASH2
Authors: Wodzinski T , Mehrjoo M , Ruiz-Lopez M , Keitel B , Kuhlmann M , Brachmanski M , Künzel S , Fajardo M , Plönjes E 
Published: July 2020

Abstract
We measured the transverse coherence at FLASH2, a variable gap undulator line at the FLASH free-electron laser user facility at DESY in Hamburg. We demonstrate, theoretically and experimentally, a revised version of Young’s double pinhole approach to perform single-shot, repeatable and non-invasive transverse coherence measurements. At beamline FL24 of FLASH2, the transverse coherence of pulses was systematically characterized at wavelengths of 8, 13.5 and 18 nm for different FEL source settings. We determine degrees of coherence of 57% to 87% in the vertical and horizontal direction, respectively. These measurements can facilitate the planning of novel, coherence-based experiments at the FLASH facility.
p53/E2F1/miR-25 axis regulates apoptosis induction in glioblastoma cells: a qualitative model
Authors: Silveira Daner A , Gupta Shantanu , Mombach José Carlos M 
Published: July 2020

Abstract
p53 is an anti-cancer protein for inducing cell cycle arrest and apoptosis. In glioblastoma multiform (GBM), p53 is able to induce apoptosis via inhibition of its negative regulator Mdm2. Experimental studies have shown that microRNA-25 (miR-25) can repress Mdm2 expression and, in turn, stabilizes p53 to induce the G1/S checkpoint in GBM cells. miR-25 expression is regulated by the cell cycle inducer molecule E2F1, which has been reported to induce apoptosis when overexpressed in GBM. However, the way p53, E2F1, and miR-25 coordinately regulate apoptosis induction in GBM is still obscure in the literature. In this study, we propose a logical model contemplating the regulatory influence of miR-25 and its regulator E2F1 on cell fate decision. Through in silico results for the wild-type case, we observed that miR-25 may stabilize p53 expression through Mdm2 inhibition inducing a G1/S checkpoint arrest or apoptosis in cells overexpressing E2F1. The predicted probabilities of our model are in good agreement with published experimental data. Moreover, we show that miR-25-induced p53 stabilization might contribute to apoptosis induction in GBM cells. These findings highlight some unrecognized mechanisms that may guide to alternative ideas for GBM therapeutic strategies.
In operando active learning of interatomic interaction during large-scale simulations
Authors: Hodapp M , Shapeev A 
Published: July 2020

Abstract
A well-known drawback of state-of-the-art machine-learning interatomic potentials is their poor ability to extrapolate beyond the training domain. For small-scale problems with tens to hundreds of atoms this can be solved by using active learning which is able to select atomic configurations on which a potential attempts extrapolation and add them to the ab initio-computed training set. In this sense an active learning algorithm can be viewed as an on-the-fly interpolation of an ab initio model. For large-scale problems, possibly involving tens of thousands of atoms, this is not feasible because one cannot afford even a single density functional theory (DFT) computation with such a large number of atoms.
This work marks a new milestone toward fully automatic ab initio-accurate large-scale atomistic simulations. We develop an active learning algorithm that identifies local subregions of the simulation region where the potential extrapolates. Then the algorithm constructs periodic configurations out of these local, non-periodic subregions, sufficiently small to be computable with plane-wave DFT codes, in order to obtain accurate ab initio energies. We benchmark our algorithm on the problem of screw dislocation motion in bcc tungsten and show that our algorithm reaches ab initio accuracy, down to typical magnitudes of numerical noise in DFT codes. We show that our algorithm reproduces material properties such as core structure, Peierls barrier, and Peierls stress. This unleashes new capabilities for computational materials science toward applications which have currently been out of scope if approached solely by ab initio methods.
Predicting radiation treatment planning evaluation parameter using artificial intelligence and machine learning
Authors: Ng Frederick , Jiang Runqing , Chow James C L 
Published: July 2020

Abstract

Purpose: This study suggested a new method predicting the dose-volume parameter for radiation treatment planning evaluation using machine learning, and to evaluate the performance of different learning algorithms in the parameter prediction. Methods: Dose distribution index (DDI) for fifty prostate volumetric modulated arc therapy plans were calculated, and compared to results predicted by machine learning using algorithms, namely, linear regression, tree regression, support vector machine (SVM) and Gaussian process regression (GPR). Root mean square error (RMSE), prediction speed and training time were determined to evaluate the performance of each algorithm. Results: From the results, it is found that the square exponential GPR algorithm had the smallest RMSE, relatively high prediction speed and short training time of 0.0038, 4,100 observation/s and 0.18 s, respectively. All linear regression, SVM and GPR algorithms performed well according to their RMSE in the range of 0.0038–0.0193. However, RMSE of the medium and coarse tree regression algorithms were found larger than 0.03, showing that they are not suitable for predicting DDI in this study. Conclusion: Machine learning can be used to predict dose-volume parameter such as DDI in radiation treatment planning QA. Selection of a suitable machine learning algorithm is important to determine the parameter effectively.
What’s in a Name? That Which We Call Capital Controls
Authors: Ghosh Atish R , Kim Jun Il , Qureshi Mahvash S 
Published: July 2020

Abstract
This paper investigates why controls on capital inflows have a bad name by tracing how capital controls have been used and perceived since the laissez-faire era of the classical gold standard. While advanced economies often employed capital controls to tame inflows during the last century, we conjecture that several factors undermined their subsequent use—most notably, a “guilt by association” with controls on capital outflows, which have typically been employed by autocratic regimes or those with failed macroeconomic policies. We formalize the idea of a possible guilt by association between inflow controls and outflow controls in a signaling model and provide some empirics consistent with it.
The Politics behind the Veil
Authors: Aksoy Ozan , Gambetta Diego 
Published: July 2020

AbstractUsing a natural experiment, we find that in provinces where Turkey’s Islamic Justice and Development Party (AKP) just won the election in 2004, women, including those who are weakly religious or non-religious, now veil far more than in provinces in which AKP just lost, the more so the poorer they are. This effect, as we predict, does not occur for praying regularly which is more costly and harder to observe practice. We argue that veiling is higher in AKP provinces not only because of a generic aim to conform to the stricter mores fostered by the victorious party. We find that those who veil, particularly those in AKP provinces who are not pious, are more politically active than those who do not veil. This may be an indication that veiling could partly be a strategic response to policies, which favour those who are or appear pious. Our study suggests that observable religious practices may have their independent dynamics driven by the pursuit of instrumental goals. Our results also suggest that parties with a religious ideology have an advantage over their secular counterparts in solving the clientelistic information problem, for they can rely on religious symbols for screening and signalling.
Safety, efficacy, and reproducibility of cavotricuspid isthmus ablation guided by the ablation index: acute results of the FLAI study
Authors: Viola Graziana , Stabile Giuseppe , Bandino Stefano , Rossi Luca , Marrazzo Natale , Pecora Domenico , Bottoni Nicola , Solimene Francesco , Schillaci Vincenzo , Scaglione Marco , Ocello Salvatore , Baiocchi Claudia , Santoro Amato , Donzelli Stefano , De Ruvo Ermenegildo , Lavalle Carlo , Sanchez-Gomez Juan Miguel , Pastor Juan Fernandez Armenta , Grandio Pilar Cabanas , Ferraris Federico , Castro Antonio , Rebellato Luca , Marchese Procolo , Adao Luis , Primo Joao , Barra Sergio , Casu Gavino 
Published: July 2020

Abstract

Aims
Ablation index (AI) is a marker of lesion quality during catheter ablation that incorporates contact force, time, and power in a weighted formula. This index was originally developed for pulmonary vein isolation as well as other left atrial procedures. The aim of our study is to evaluate the feasibility and efficacy of the AI for the ablation of the cavotricuspid isthmus (CTI) in patients presenting with typical atrial flutter (AFL).

Methods and results
This prospective multicentre non-randomized study enrolled 412 consecutive patients with typical AFL undergoing AI-guided cavotricuspid isthmus ablation. The procedure was performed targeting an AI of 500 and an inter-lesion distance measurement of ≤6 mm. The primary endpoints were CTI ‘first-pass’ block and persistent block after a 20-min waiting time. Secondary endpoints included procedural and radiofrequency duration and fluoroscopic time. A total of 412 consecutive patients were enrolled in 31 centres (mean age 64.9 ± 9.8; 72.1% males and 27.7% with structural heart disease). The CTI bidirectional ‘first-pass’ block was reached in 355 patients (88.3%), whereas CTI block at the end of the waiting time was achieved in 405 patients (98.3%). Mean procedural, radiofrequency, and fluoroscopic time were 56.5 ± 28.1, 7.8 ± 4.8, and 1.9 ± 4.8 min, respectively. There were no major procedural complications. There was no significant inter-operator variability in the ability to achieve any of the primary endpoints.

Conclusion
AI-guided ablation with an inter-lesion distance ≤6 mm represents an effective, safe, and highly reproducible strategy to achieve bidirectional block in the treatment of typical AFL.
Effectiveness of clinical decision support systems and telemedicine on outcomes of depression: a cluster randomized trial in general practice
Authors: Balestrieri Matteo , Sisti Davide , Rocchi Marco , Rucci Paola , Simon Gregory , Araya Ricardo , de Girolamo Giovanni 
Published: July 2020

Abstract

Background
Computerized Clinical Decision Support Systems (CCDSS) are information technology tools, designed to improve clinical decision-making. Telemedicine is a health care service delivery using videoconferencing, telephone or messaging technologies.

Objectives
Our project aimed at testing the effectiveness of a composite CCDSS and telemedicine approach designed to treat depression in primary care.

Methods
This cluster randomized trial involved four GP clinics located in Northern Italy. Two clinics were assigned to the experimental protocol, and two served as controls. The study compared the telemedicine group (TG), in which GPs had access to a CCDSS platform, with the control group (CG) in which GPs provided treatment as usual (TAU). Patients scoring ≥11 on Patient Heath Questionnaire and ≥26 on the Inventory of Depressive Symptomatology-Self-Report were eligible for participation. Patients were also administered the World Health Organization Quality of Life-BREF to assess quality of life and Medical Interview Satisfaction Scale 21 to assess satisfaction with the medical interview.

Results
Overall, 2810 patients were screened and 66 in the experimental group and 32 in the CG passed the screening stages and met inclusion criteria. The percentage of remitters at 6 months was significantly higher in the TG than in the CG group (24.1% versus 3.1%, χ 2 = 6.6, P = 0.01). This difference remained significant after adjusting for baseline confounders. Physical and psychological quality of life improved significantly from baseline in both groups. Patients reported, on average, good satisfaction with the medical interview.

Conclusions
Our study showed that a combined CCDSS and telemedicine approach may be more effective than the TAU offered by GPs to patients with depression.

Trial registration
The trial was registered on https://clinicaltrials.gov/ on 5 October 2012 with identifier: NCT01701791. The first participant was enrolled on 5 May 2014 and the study was completed on May 2016.
Mutual environmental drivers of the community composition, functional attributes and co-occurrence patterns of bacterioplankton in the composite aquatic ecosystem of Taihu watershed in China
Authors: Liu Mingkun , Han Xue , Tong Jun , Zhu Huifeng , Bai Xiaohui 
Published: July 2020

ABSTRACTThis study aimed to determine the environmental and ecological factors influencing the planktonic prokaryotic community profiles in the composite ecosystem comprising Taihu Lake, Taipu River and Jinze Reservoir in the Taihu Watershed in China. A total of 42 water samples were intermittently collected from different sites in 6 months across four seasons. Physicochemical characteristics of the ecosystem, bacterioplankton diversity and composition, the presence of co-occurrence patterns, and environmental predictors of ecological modules in the bacterioplankton network were determined. The central species played a more important role in regulating the structure and function of the bacterioplankton community and in responding to environmental contamination than the entire community. The relative abundance of the phylum Proteobacteria and the class Betaproteobacteria varied significantly between months and locations, which were identified as core functional taxa. A non-random co-occurrence pattern and function-driven modular structure were observed in the bacterioplankton co-occurrence network. Dissolved oxygen and ammonium nitrogen were the major and mutual environmental predictors of the bacterioplankton community composition, functional attributes and relative abundance of ecological modules. The results improve our understanding of the impact of anthropogenic contamination on bacterioplankton diversity and biogeochemical cycles and the formulation of strategies for bioremediation of the Taihu Watershed.
Immune responses of meningococcal B outer membrane vesicles in middle-aged mice
Authors: Trzewikoswki de Lima Gabriela , Rodrigues Thais Sousa , Portilho Amanda Izeli , Correa Victor Araujo , Gaspar Emanuelle Baldo , De Gaspari Elizabeth 
Published: July 2020

ABSTRACTThe elderly are more likely to die when infected with Neisseria meningitidis. Aging is associated with immune system dysfunctions that impair responses to vaccines and infections. Therefore, immunization of middle-aged individuals could be beneficial. This study aims to evaluate the immunogenicity of N. meningitidis B outer membrane vesicles (OMVs) complexed to two different adjuvants. Middle-aged BALB/c and A/Sn mice were immunized and subsequent immune response was assessed by ELISA, immunoblotting and ELISpot. IgG levels were similar between the animals immunized with OMVs complexed to adjuvants. A total of 235 days after the last immunization only A/Sn mice presented higher IgG levels than those observed in the baseline, especially the group immunized with OMVs and aluminum hydroxide. The predominant IgG subclasses were IgG2a and IgG2b. Immunization with the three-dose regimen generated IgG antibodies that recognized a variety of antigens present in the homologous and heterologous meningococcal OMVs evaluated. There was an increase in the frequency of antigen-specific IFN-γ secreting splenocytes, after in vitro stimulation, in mice immunized with OMVs and adjuvants compared to the control group, almost 1 year after the last immunization. Both adjuvants showed similar performance. Immunization of middle-aged mice has generated a robust immune response and it appears to be advantageous.
Two Lineages of Pseudomonas aeruginosa Filamentous Phages: Structural Uniformity over Integration Preferences
Authors: Fiedoruk Krzysztof , Zakrzewska Magdalena , Daniluk Tamara , Piktel Ewelina , Chmielewska Sylwia , Bucki Robert 
Published: July 2020

AbstractPseudomonas aeruginosa filamentous (Pf) bacteriophages are important factors contributing to the pathogenicity of this opportunistic bacterium, including biofilm formation and suppression of bacterial phagocytosis by macrophages. In addition, the capacity of Pf phages to form liquid crystal structures and their high negative charge density makes them potent sequesters of cationic antibacterial agents, such as aminoglycoside antibiotics or host antimicrobial peptides. Therefore, Pf phages have been proposed as a potential biomarker for risk of antibiotic resistance development. The majority of studies describing biological functions of Pf viruses have been performed with only three of them: Pf1, Pf4, and Pf5. However, our analysis revealed that Pf phages exist as two evolutionary lineages (I and II), characterized by substantially different structural/morphogenesis properties, despite sharing the same integration sites in the host chromosomes. All aforementioned model Pf phages are members of the lineage I. Hence, it is reasonable to speculate that their interactions with P. aeruginosa and impact on its pathogenicity may be not completely extrapolated to the lineage II members. Furthermore, in order to organize the present numerical nomenclature of Pf phages, we propose a more informative approach based on the insertion sites, that is, Pf-tRNA-Gly, -Met, -Sec, -tmRNA, and -DR (direct repeats), which are fully compatible with one of five types of tyrosine integrases/recombinases XerC/D carried by these viruses. Finally, we discuss possible evolutionary mechanisms behind this division and consequences from the perspective of virus–virus, virus–bacterium, and virus–human interactions.