bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Cardiometabolic Disease Markers by Type I Interferon Inhibition in Systemic Lupus Erythematosus
Authors: Casey Kerry A. , Smith Michael A. , Sinibaldi Dominic , Seto Nickie L. , Playford Martin P. , Wang Xinghao , Carlucci Philip M. , Wang Liangwei , Illei Gabor , Yu Binbing , Wang Shiliang , Remaley Alan T. , Mehta Nehal N. , Kaplan Mariana J. , White Wendy I. 
Published: September 2020

ObjectiveNeutrophil dysregulation and the type I interferon (IFN) axis have been proposed to contribute to premature cardiovascular disease, a leading cause of mortality in patients with systemic lupus erythematosus (SLE). In the present study, we evaluated the ability of anifrolumab, a type I IFN receptor–blocking antibody, to reduce neutrophil extracellular trap (NET) formation and modulate cardiometabolic disease markers in comparison to placebo.MethodsStudy subjects comprised patients with moderate‐to‐severe SLE who were enrolled in phase IIb of the MUSE trial (A Phase II, Randomized Study to Evaluate the Efficacy and Safety of MEDI‐546 in Subjects with Systemic Lupus Erythematosus), with healthy individuals as controls. Blood samples were collected from SLE patients (n = 305) and healthy controls (n = 10–20) before the initiation of treatment (baseline) and from SLE patients after they had been treated with 300 mg of anifrolumab (n = 99) or placebo (n = 102). Baseline IFN gene signature test status was determined, and the IFN gene signature (21‐gene panel) was monitored over time. Serum proteins were measured by multiplex immunoassay or ultrasensitive Simoa assay. NET complexes, cholesterol efflux capacity (CEC), and glycoprotein acetylation (GlycA) and other lipid parameters were assessed in plasma.ResultsFormation of NET complexes and levels of tumor necrosis factor (TNF) and interleukin‐10 (IL‐10) were correlated with extent of type I IFN pathway activity. NET complexes and IL‐10 levels were up‐regulated in SLE patients compared to healthy controls (P < 0.008). The cardiometabolic disease markers CEC and GlycA were also found to be dysregulated in patients with SLE (P < 0.001 versus healthy controls). Type I IFN receptor inhibition with anifrolumab significantly reduced NET complexes and GlycA and improved CEC compared to baseline (P < 0.05) whereas no improvements were seen with placebo. Levels of TNF and IL‐10 were reduced with anifrolumab compared to placebo (P < 0.05).ConclusionThese data support a key role for type I IFNs in modulating factors contributing to SLE vasculopathy and suggest that inhibition of this pathway could decrease cardiovascular risk in individuals with SLE.
Instandsetzung von gefugten Betonflächen mit einer dünnen Schicht aus Carbonbeton
Authors: Farwig Kristina , Neumann Julia , Schneider Robert , Breitenbücher Rolf , Curbach Manfred 
Published: September 2020

AbstractEin typisches Anwendungsfeld für gefugte Betonflächen sind Betonfahrbahnen. Diese sind hohen Beanspruchungen aus dem Verkehrsaufkommen und extremen Witterungsbedingungen ausgesetzt. Um wilde Risse aus daraus entstehenden Zwangsspannungen zu verhindern, werden in der Regel Querscheinfugen eingebracht. Diese stellen jedoch zugleich eine Schwachstelle im Beton dar, sodass eine kontinuierliche Instandhaltung und Wartung notwendig werden. Eine ökologisch und ökonomisch sinnvolle Alternative zur Erneuerung der gesamten Betondecke ist die Sanierung der Betonfahrbahn mithilfe einer fugenlosen und zugleich dünnen Deckschicht aus Carbonbeton. Eine Trennung des Verbunds zwischen Alt‐ und Carbonbeton im Bereich der Querscheinfuge gewährleistet die Verteilung entstehender Risse und die Reduzierung der Einzelrissbreiten durch multiple Rissbildung. Flüssigkeiten können so weniger tief in den Beton eindringen und schaden weder dem Altbeton noch der korrosionsresistenten Carbonbewehrung.
Nesting and fate of transplanted stem cells in hypoxic/ischemic injured tissues: The role ofHIF1α/sirtuins and downstream molecular interactions
Authors: Barzegari Abolfazl , Omidi Yadollah , Gueguen Virginie , Meddahi‐Pellé Anne , Letourneur Didier , Pavon‐Djavid Graciela 
Published: September 2020

AbstractThe nesting mechanisms and programming for the fate of implanted stem cells in the damaged tissue have been critical issues in designing and achieving cell therapies. The fracture site can induce senescence or apoptosis based on the surrounding harsh conditions, hypoxia, and oxidative stress (OS). Respiration deficiency, disruption in energy metabolism, and consequently OS induction change the biophysical, biochemical, and cellular components of the native tissue. Additionally, the homeostatic molecular players and cell signaling might be changed. Despite all aforementioned issues, in the native stem cell niche, physiological hypoxia is not toxic; rather, it is vitally required for homing, self‐renewal, and differentiation. Hence, the key macromolecular players involved in the support of stem cell survival and re‐adaptation to a new dysfunctional niche must be understood for managing the cell therapy outcome. Hypoxia‐inducible factor 1‐alpha is the master transcriptional regulator, involved in the cell response to hypoxia and the adaptation of stem cells to a new niche. This protein is regulated by interaction with sirtuins. Sirtuins are highly conserved NAD+‐dependent enzymes that monitor the cellular energy status and modulate gene transcription, genome stability, and energy metabolism in response to environmental signals to modulate the homing and fate of stem cells. Herein, new insights into the nesting of stem cells in hypoxic–ischemic injured tissues were provided and their programming in a new dysfunctional niche along with the involved complex macromolecular players were critically discussed.
Circulating miR‐155, let‐7c, miR‐21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer
Authors: Aksan Hulya , Kundaktepe Berrin Papila , Sayili Ugurcan , Velidedeoglu Mehmet , Simsek Gonul , Koksal Selcuk , Gelisgen Remise , Yaylim Ilhan , Uzun Hafize 
Published: September 2020

AbstractThis study investigates whether the circulating miR‐155, let‐7c, miR‐21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). Forty‐five patients with BC, 50 patients with IGM, and 48 healthy volunteers were included in the study. Serum miR‐21 expression was significantly higher in BC (fold change = 2.42) and IGM group (fold change = 1.33) compared to control (p < .001). Serum miR‐155 and let‐7c expression levels were significantly lower in both groups compared to the control group (p < .001). miR‐21 expression in BC was significantly higher than IGM (fold change = 1.976; p < .001). PTEN levels in BC were significantly higher than IGM (p < .001) and significantly lower than the control group (p < .001); the IGM group was significantly lower than the control group (p < .001). In addition to radiological data, serum miR‐21 and PTEN levels may be noninvasive biomarkers that can help differentiate IGM from BC. The results of the study will lead to future studies in the differential diagnosis of IGM and BC.
Dynamic co‐culture metabolic models reveal the fermentation dynamics, metabolic capacities and interplays of cheese starter cultures
Authors: Özcan Emrah , Seven Merve , Şirin Burcu , Çakır Tunahan , Nikerel Emrah , Teusink Bas , Toksoy Öner Ebru 
Published: September 2020

AbstractIn this study, we have investigated the cheese starter culture as a microbial community through a question: can the metabolic behaviour of a co‐culture be explained by the characterized individual organism that constituted the co‐culture? To address this question, the dairy‐origin lactic acid bacteria Lactococcus lactis subsp. cremoris, Lactococcus lactis subsp. lactis, Streptococcus thermophilus and Leuconostoc mesenteroides, commonly used in cheese starter cultures, were grown in pure and four different co‐cultures. We used a dynamic metabolic modelling approach based on the integration of the genome‐scale metabolic networks of the involved organisms to simulate the co‐cultures. The strain‐specific kinetic parameters of dynamic models were estimated using the pure culture experiments and they were subsequently applied to co‐culture models. Biomass, carbon source, lactic acid and most of the amino acid concentration profiles simulated by the co‐culture models fit closely to the experimental results and the co‐culture models explained the mechanisms behind the dynamic microbial abundance. We then applied the co‐culture models to estimate further information on the co‐cultures that could not be obtained by the experimental method used. This includes estimation of the profile of various metabolites in the co‐culture medium such as flavour compounds produced and the individual organism level metabolic exchange flux profiles, which revealed the potential metabolic interactions between organisms in the co‐cultures.
Development and validation of prognostic nomogram in patients with nonmetastatic malignant melanoma: a SEER population‐based study
Authors: Xiao Yu , Peng Shanshan , Hu Youhong , Zhang Jie , Cao Xianwei 
Published: September 2020

AbstractBackgroundThe condition of tumor recurrence and overall death can be worried in the progress of nonmetastatic malignant melanoma (NMMM). Our goal was to construct and validate a prognostic nomogram from a large population database, which is vital for physicians to predict the 3‐ and 5‐year overall survival (OS) rates of patients with NMMM.MethodsAccording to the Surveillance, Epidemiology, and End Results (SEER) program, patients were collected and randomly assigned into the training and validation cohorts. Several independent risk factors were identified based on the methods of univariable and multivariable cox hazards regression and were incorporated to develop a nomogram. The concordance index (C‐index), the area under the receiver operating characteristics (AUC) curve and calibration plot were confirmed to assess predictive power of the nomogram. Decision curve analysis (DCA) was performed to measure nomogram for the clinical practice.ResultsA total of 66192 eligible patients, randomly assigned into 70% of training (n = 46 336) and 30% of validation cohorts (n = 19 856), were selected in this study. The selected independent factors were applied to develop a nomogram, and validated indexes indicated nomogram had a good discrimination ability. The C‐index for OS rates was 0.817 (95% CI: 0.811‐0.823) in training cohort and 0.817 (95% CI: 0.809‐0.825) in validation cohort, respectively. The AUCs of 3‐ and 5‐year OS rates were more than 0.79, and the calibration plots also showed a good power for the nomogram. DCA demonstrated that constructed nomogram can provide clinical net benefit.ConclusionWe constructed a novel nomogram that more accurately and comprehensively predict OS with nonmetastatic malignant melanoma patients, which is vital for clinician to improve individual treatment, make reasonable clinical decisions, and set appropriate follow‐up strategies.
Convalescent Plasma for the Treatment of Severe COVID‐19 Infection in Cancer Patients
Authors: Tremblay Douglas , Seah Carina , Schneider Thomas , Bhalla Sheena , Feld Jonathan , Naymagon Leonard , Wang Bo , Patel Vaibhav , Jun Tomi , Jandl Thomas , Rahman Farah , Liu Sean T. H. , Aberg Judith A. , Bouvier Nicole ,   The Mount Sinai Health System Convalescent Plasma Team
Published: September 2020

AbstractBackgroundPatients with malignancy are particularly vulnerable to infection with Severe Acute Respiratory Disease‐Coronavirus‐2 (SARS‐CoV‐2) given their immunodeficiency secondary to their underlying disease and cancer‐directed therapy. We report a case series of patients with cancer who received convalescent plasma, an investigational therapy for severe Coronavirus Disease 2019 (COVID‐19).MethodsPatients with cancer were identified who received convalescent plasma. Enrolled patients had confirmed COVID‐19 with severe or life‐threatening disease and were transfused with convalescent plasma from donors with a SARS‐CoV‐2 anti‐spike antibody titer of ≥ 1:320 dilution. Oxygen requirements and clinical outcomes of interests were captured as well as laboratory parameters at baseline and 3 days after treatment.ResultsWe identified 24 patients with cancer, 14 of whom had a hematological malignancy, who were treated with convalescent plasma. Fifteen patients (62.5%) were on cancer‐directed treatment at the time of COVID‐19 infection. After a median of hospital duration of 9 days, 13 patients (54.2%) had been discharged home, 1 patient (4.2%) was still hospitalized, and 10 patients had died (41.7%). Non‐intubated patients, particularly those on nasal cannula alone, had favorable outcomes. Three mild febrile non‐hemolytic transfusion reactions were observed. C‐reactive protein significantly decreased after 3 days of treatment, while other laboratory parameters including ferritin and D‐dimer remained unchanged.ConclusionsConvalescent plasma may be a promising therapy in cancer patients with COVID‐19.
Differences and Correlations of Morphological Characteristics and Fatty Acid Profiles of Seeds of Toona sinensis
Authors: Su Shang , Wang Li‐Jin , Ni Jian‐Wei , Geng Yong‐Hang , Xu Xin‐Qiao 
Published: September 2020

AbstractToona sinensis (A.Juss.) M.Roem., a multi‐purpose tree of Meliaceae, is widely distributed and intensively cultivated in Asia, yet its high yielding, lipid‐rich seeds are rarely exploited. The present study systematically analyzed the differences and correlations of seed morphological characteristics and fatty acid (FA) profiles of 62 representative T. sinensis germplasms distributed across northern to southern China. T. sinensis seeds were rich in total FAs (TFA, 107.03–176.18 mg/g). Additionally, linoleic acid (54.69–100.59 mg/g), α‐linolenic acid (ALA, 22.47–45.02 mg/g), oleic acid (OA, 5.12–23.94 mg/g), palmitic acid (6.87–14.14 mg/g), stearic acid (SA, 3.13–6.57 mg/g) and elaidic acid (1.70–2.88 mg/g) were the major FAs measured by GC/MS analysis. Size (average width of 3.94±0.01 mm and length of 5.79±0.02 mm) and mass (average thousand‐seed weight of 10.52±0.17 g) were greater in T. sinensis seeds collected south than north of 30° latitude. These traits were also positively correlated with unsaturated FA content and negatively related to SA and saturated FA contents (P<0.05). Significant positive correlations were found between seed length and polyunsaturated FA (R2=0.370) and ALA levels (R2=0.296), as well as between thousand‐seed weight and monounsaturated FAs (R2=0.309) and OA levels (R2=0.297) (P<0.05). Seventeen T. sinensis germplasms gathered by cluster analysis as cluster IV were determined as desirable for oil processing due to their higher TFA and ALA contents and greater seed size and mass than others. Generally, the wider, heavier, and especially longer seeds of T. sinensis contain much higher levels of FAs, especially ALA, and are the more promising sources for breeding and the oil processing industry.
Management of cracked tooth using simvastatin as intracanal medicament
Authors: Fawzy Mohamed , Alhadainy Hatem A. , Salah‐Uddin Muhammad , Abdulrab Saleem 
Published: September 2020

AbstractCracked tooth syndrome is presented as pain associated with biting and sensitivity. Intracanal medication with simvastatin stimulates hard tissue formation at crack line, and the tooth was functioning on the follow‐ups.
Osteochondroma of the distal tibia in an 8‐year‐old child: Do we need to excise a benign tumor?
Authors: Galanis Nikiforos , Delniotis Ioannis , Noussios George , Katsourakis Anastasios , Kitridis Dimitrios , Leidinger Benedikt , Givissis Panagiotis 
Published: September 2020

AbstractOsteochondromas are benign tumors that can be responsible for angular deformities, limb‐length discrepancy, and impending fractures of the neighboring bones. The risk of future fractures and joint malalignment is an indication for surgical intervention.
Chemo‐Enzymatic Synthesis of S. mansoni O‐Glycans and Their Evaluation as Ligands for C‐Type Lectin Receptors MGL, DC‐SIGN, and DC‐SIGNR
Authors: Pham Julie , Hernandez Alvaro , Cioce Anna , Achilli Silvia , Goti Giulio , Vivès Corinne , Thepaut Michel , Bernardi Anna , Fieschi Franck , Reichardt Niels‐Christian 
Published: September 2020

AbstractDue to their interactions with C‐type lectin receptors (CLRs), glycans from the helminth Schistosoma mansoni represent promising leads for treatment of autoimmune diseases, allergies or cancer. We chemo‐enzymatically synthesized nine O‐glycans based on the two predominant O‐glycan cores observed in the infectious stages of schistosomiasis, the mucin core 2 and the S. mansoni core. The O‐glycans were fucosylated next to a selection of N‐glycans directly on a microarray slide using a recombinant fucosyltransferase and GDP‐fucose or GDP‐6‐azidofucose as donor. Binding assays with fluorescently labelled human CLRs DC‐SIGN, DC‐SIGNR and MGL revealed the novel O‐glycan O8 as the best ligand for MGL from our panel. Significant binding to DC‐SIGN was also found for azido‐fucosylated glycans. Contrasting binding specificities were observed between the monovalent carbohydrate recognition domain (CRD) and the tetravalent extracellular domain (ECD) of DC‐SIGNR.
Utilization of CO2 Feedstock for Organic Synthesis by Visible‐Light Photoredox Catalysis
Authors: Pradhan Suman , Roy Sourav , Sahoo Basudev , Chatterjee Indranil 
Published: September 2020

AbstractCO2 is a highly abundant, green, and sustainable carbon feedstock. Despite its kinetic inertness and thermodynamic stability, the development of various catalytic techniques has enabled the conversion of CO2 to value‐added products such as carboxylic acids, amino acids, and heterocyclic compounds, where visible‐light photocatalysis has emerged to be an efficient promoter of these processes. This Minireview covers the progress in the areas of CO2 incorporation onto organic matters based on the combined venture of renewable resources of CO2 and light energy with significant emphasis on the last three years’ developments.
Directing Group‐Promoted Inert C−O Bond Activation Using Versatile Boronic Acid as a Coupling Agent
Authors: Ambre Ram , Wang Ting‐Hsuan , Xian Anmei , Chen Yu‐Shiuan , Liang Yu‐Fu , Jurca Titel , Zhao Lili , Ong Tiow‐Gan 
Published: September 2020

AbstractA simple Ni(cod)2 and carbene mediated strategy facilitates the efficient catalytic cross‐coupling of methoxyarenes with a variety of organoboron reagents. Directing groups facilitate the activation of inert C−O bonds in under‐utilized aryl methyl ethers enabling their adaptation for C−C cross‐coupling reactions as less toxic surrogates to the ubiquitous haloarenes. The method reported enables C−C cross‐coupling with readily available and economical arylboronic acid reagents, which is unprecedented, and compares well with other organoboron reagents with similarly high reactivity. Extension to directing group assisted chemo‐selective C−O bond cleavage, and further application towards the synthesis of novel bifunctionalized biaryls is reported. Key to the success of this protocol is the use of directing groups proximal to the reaction center to facilitate the activation of the inert C−OMe bond.
Schneller zum Digitalen Zwilling
Authors:   Codewerk GmbH, Karsruhe
Published: September 2020

AbstractPlattformen für das Industrial Internet of Things gibt es inzwischen mehrere ‐ doch brauchbare, schnell einführbare Lösungen in Form von Apps mit direktem Praxisnutzen, noch eher wenige. Eine davon stellen nun die Entwickler von Codewerk vor: Den Visual Hierarchy Modeler.
Hochflexibel filtern
Authors: Süß Wolfgang 
Published: September 2020

AbstractUnbeständige Märkte, häufigere Produktwechsel: In der feinchemischen und pharmazeutischen Industrie steigt der Bedarf an flexiblen Anlagen. Modular aufgebaute Produktionssysteme ermöglichen kürzere Markteinführungszeiten und beschleunigte Engineering‐PhasUnbeständige Märkte, häufigere Produktwechsel: In der feinchemischen und pharmazeutischen Industrie steigt der Bedarf an flexiblen Anlagen. Modular aufgebaute Produktionssysteme ermöglichen kürzere Markteinführungszeiten und beschleunigte Engineering‐Phasen. Für die Fest‐Flüssig‐Trennung hat BHS‐Sonthofen nun ein neues Anlagenkonzept umgesetzt. Das Ergebnis: eine modulare Versuchsanlage inklusive Druckdrehfilter.
Aufbereitung ist alles
Authors: Gerl Stefan 
Published: September 2020

AbstractBei der Verhüttung von Erzen fallen Stäube an, die noch geringe Mengen an Metallen enthalten. In der Vergangenheit wurden die Stäube in oberirdischen Lagern deponiert. Lange Zeit war es – auch wegen relativ niedriger Metallpreise – wirtschaftlich nicht interessant, Metalle aus diesen Abfallstoffen zurückzugewinnen. In vielen Ländern erlauben neue gesetzliche Vorgaben zukünftig keine oberirdische Deponierung mehr. In Verbindung mit den heute deutlich höheren Metallpreisen stellt eine Verwertung der fortlaufend anfallenden aber auch der deponierten Stäube eine wirtschaftlich interessante Alternative zur Deponierung unter Tage dar. Die Dispergier‐ und Trocknungstechnik von EIRICH ermöglicht eine wirtschaftliche Aufbereitung.
Development and Assembly of a Flow Cell for Single‐Pass Continuous Electroorganic Synthesis Using Laser‐Cut Components
Authors: Jud Wolfgang , Kappe C. Oliver , Cantillo David 
Published: September 2020

AbstractFlow electrolysis cells are essential for the scale up of synthetic organic electrochemistry. We have developed a simple and inexpensive parallel plate flow cell that can be easily assembled using a stack of laser‐cut Mylar foils, which act as gaskets, insulating material, interelectrode gap and flow channel. The ease with which the laser‐cutting pattern can be customized has enabled the development of interelectrode separators with mixing geometries, which improve the mass transfer and thus the current efficiency. The performance of the flow electrolysis cell has been evaluated using the anodic decarboxylative methoxylation of diphenylacetic acid as model transformation. Very high conversions and selectivities have been achieved with single‐pass processing, with nearly quantitative current efficiency in some cases.
Exploring consumer participation in environment management: Findings from two‐staged structural equation modelling‐artificial neural network approach
Authors: Najmi Arsalan , Kanapathy Kanagi , Aziz Azmin A. 
Published: September 2020

AbstractA manufacturer's extended producer responsibility for environment management cannot be fulfilled without the participation of end consumers. Therefore, the present study aims to explore the role of consumers in recycling programs of end of life mobile phones. Based on the theory of planned behavior, hypotheses were developed for which data was collected from 746 respondents and a two staged structural equation modelling‐artificial neural network was applied. Both techniques generated similar results which provides validation of the hypothesized relationships. Based on the findings, results are discussed and accordingly policy implications are recommended.
Diversification of the Renewable Furanic Platform via 5‐(Chloromethyl)furfural‐Based Carbon Nucleophiles
Authors: Miao Haoqian , Shevchenko Nikolay , Otsuki Andrew L. , Mascal Mark 
Published: September 2020

AbstractBiobased 5‐(chloromethyl)furoate and 5‐methylfuroate esters can be deprotonated to function as furylogous lithium enolates, and the former can also undergo zinc insertion to access Reformatsky‐type chemistry. Carbon nucleophilicity represents hitherto little‐explored reactivity in these key carbohydrate‐derived platform molecules, expanding their synthetic utility and potentially opening up new sustainable product markets (e. g., in epoxy resins or biobased dyes).