bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Two-Temperature, Rotation, Initial Stressed Magnetic Field on Rayleigh Wave in Half-Plane
Authors: Sharma Heena , Kumari Sangeeta 
Published: February 2020

Abstract
In the present paper, we consider the governing equation for generalized thermoelastic media under the effect of magnetic fleld, rotation, initial stress, and two-temperature parameter for Rayleigh wave in half-space. The secular equation of Rayleigh wave is also deduced using surface wave solution, which also satisfy the radiation condition for thermally insulated/isothermal surface. The velocity and amplitude attenuation factor of Rayleigh wave is also computed for a particular material. The effect of two-temperature, rotation, and initial stress parameters on velocity of propagation and amplitude attenuation factor is shown graphically.
Asymmetric Conduction in an Infinite Functionally Graded Cylinder: Two-Dimensional Exact Analytical Solution Under General Boundary Conditions
Authors: Delouei Amin Amiri , Emamian Amin , Karimnejad Sajjad , Sajjadi Hasan , Jing Dengwei 
Published: February 2020

Abstract
This paper focuses on using an analytical method to obtain an exact solution for a long cylindrical vessel made of functionally graded materials (FGMs). Heat conduction equations are assumed to be in both radial and circumferential directions. The conduction coefficients are considered as different power-law functions of the radius. The general linear boundary conditions are adopted to make the solution applicable to the full range of problems. The obtained solution is successfully validated. Through solving illustrative test examples, the effects of material constants and boundary conditions on temperature distribution are studied. The obtained formulation can be utilized for tailoring of FGM based on the actual sophisticated thermal boundary conditions in the production process. The current analytical findings can help to manage the temperature distribution in FGMs which is an essential parameter in controlling the thermal stresses.
Brain Computer Interface Classifiers for Semi-Autonomous Wheelchair Using Fuzzy Logic Optimization
Authors: Nandikolla Vidya K. , Van Leeuwen Travis 
Published: February 2020

Abstract
A brain–computer interface (BCI)-based controller bridges the gap between smart wheelchairs and physically impaired persons with severe conditions. This paper presents the design of a hybrid BCI controller with six classifiers using an electroencephalogram (EEG) headset to detect hand motor imagery (MI) and jaw electromyography (EMG) signals. A BCI controller and semi-autonomous system is developed to control a smart wheelchair in conjunction with its semi-autonomous capabilities. For data acquisition, an openvibe system and a commercial grade EEG headset are used. A multiple common spatial pattern (CSP) filter and Linear discriminant analysis (LDA) classifier system is used to process and classify the user's brain activity. To convert the classifier data into a signal that is compatible with the semi-autonomous wheelchair system, a fuzzy logic controller (FLC) is integrated in LabVIEW. Subjects are trained to use the BCI system and the classifier profiles are optimized for each user and the results are analyzed for this study. The openvibe “Replay” script and recorded training data are used to evaluate the performance of the controller scheme. For each subject, positive, negative, and false-positive executions are recorded. During the initial testing phase, the positive rates for subjects were strong, but false-positive rates were too high to be used. Therefore, the design is iterated by changing the rules of the FLC and configuration of the LabVIEW script. The configuration with the best positive rates for turn executions is chosen where the average positive rate for turning is 0.68 for subject 1 and 0.64 for subject 2.
Accuracy of Functional Movement Screen Deep Squat Scoring and the Influence of Optimized Scoring Criteria: A 3-Dimensional Kinematic Approach
Authors: Scibek Eric P. , Moran Matthew F. , Edmond Susan L. 
Published: February 2020

Context: The deep squat (DS) test is a component of the functional movement screen, which is used to assess the quality of fundamental movement patterns; however, the accuracy of the DS has not been studied. The DS is a complex, total body movement pattern with evaluation required at several points along the kinematic chain. Objective: To assess the accuracy of DS scoring by an athletic trainer, physical therapist, and exercise science professional via a comparative analysis with kinematic data (KD) and to identify scoring criteria that would improve agreement between raters and KD scores. Design: Cross-sectional study. Setting: Motion analysis laboratory. Participants: A rater from each of 3 movement science disciplines rated the DS of 23 male college athletes (20.3 [1.2] y; 70.5 [3.5] kg). Interventions: Subjects were outfitted with reflective markers and asked to perform the DS. The DS performance was scored by 3 raters and kinematic analysis. Subsequently, the optimal set of criteria that minimized the difference between mode rater score and KD was determined via a Nelder–Mead simplex optimization routine. Main Outcome Measures: Intraclass correlation coefficients (ICCs) were calculated using SPSS (version 23; IBM, Armonk, NY) to determine tester agreement with the KD score and between the mode score and KD score. Results: Agreement was poor for the athletic trainer (ICC = .387), physical therapist (ICC = .298), exercise science professional (ICC = .378), and raters’ DS scores when compared with the KD. Agreement was poor for the mode score when compared with KD prior to optimization and good following optimization (ICC = .830), thereby allowing identification of specific scoring errors. Conclusions: Agreement for DS scores is poor when compared with KD; however, it may be improved with optimization of DS scoring criteria.
Effects of Self-Massage Using a Foam Roller on Ankle Range of Motion and Gastrocnemius Fascicle Length and Muscle Hardness: A Pilot Study
Authors: Yoshimura Akane , Schleip Robert , Hirose Norikazu 
Published: February 2020

Context: Several studies have reported that self-massage using a foam roller (FR) increased joint range of motion (ROM) immediately. However, the mechanism of increasing ROM by the FR intervention has not been elucidated. Objective: To clarify the mechanism by investigating properties and morphological changes of muscles targeted by the FR intervention. Design: An interventional study. Setting: An athletic training laboratory. Participants: Ten male college volunteers with no injuries in their lower limbs (mean [SD]: age 23.8 [3.2] y, height 173.2 [4.9] cm, weight 69.5 [8.6] kg). Intervention: The FR intervention on the right plantar flexors for 3 minutes. Main Outcome Measures: Maximum ankle ROM, muscle hardness, and fascicle length of the gastrocnemius muscle at the neutral (0°), maximum dorsiflexion, and maximum plantar flexion positions. All measurements were conducted before (PRE) and after (POST) the FR intervention. Results: Dorsiflexion ROM increased significantly at POST (PRE: 13.6° [8.0°], POST: 16.6° [8.4°]; P < .001), although plantar flexion ROM did not change significantly between PRE and POST (PRE: 40.0° [6.1°], POST: 41.1° [4.9°]). There was no significant difference in muscle hardness and fascicle length between PRE and POST in any of the angles. Conclusions: Dorsiflexion ROM increased significantly by the FR intervention in the present study; however, muscle hardness and fascicle length did not change. FR may affect not only the muscle but also the fascia, tendon, and muscle-tendon unit. The FR protocol of the present study can be applied in clinical situations, because it was found to be effective to increase ROM.
Along-strike variations in sediment provenance within the Nanaimo basin reveal mechanisms of forearc basin sediment influx events
Authors: Coutts Daniel S. , Matthews William A. , Englert Rebecca G. , Brooks Morgan D. , Boivin Marie-Pier , Hubbard Stephen M. 
Published: February 2020

AbstractThe along-strike variability in sediment provenance within the Nanaimo basin is important for understanding the tectonic evolution of North America’s Late Cretaceous Pacific margin, providing context for paleogeographic reconstructions. Here, we provide 35 point-counted sandstone samples and 22 new detrital zircon samples from the Nanaimo basin. These new detrital zircon samples compose a portion of a basin-wide data set (N = 49, n = 10,942) that is leveraged to discern spatio-temporal changes in sediment provenance. Provenance data demonstrates that the majority of Nanaimo basin strata were sourced from regions within and east of the Coast Mountains Batholith, while only the southernmost Nanaimo basin, exposed in the San Juan Islands, was supplied sediment from the North Cascade thrust system. Additionally, near-identical age modes and synchronous changes in detrital zircon facies are used to hypothesize a correlation between the Nanaimo Group and the protolith of the Swakane Gneiss. These observations, along with previously identified events in the Cordillera, are used to define two basin-wide events that affected the Nanaimo basin: the first at 84 Ma and the second at 72 Ma. The first event is correlated to the onset of Kula-Farallon spreading, which affected basin subsidence, introduced Proterozoic detrital zircon to the central and southern Nanaimo basin, and uplifted the North Cascade thrust system. The second basin-wide event, which is speculated to have been driven by increased rates of subduction and obliquity, resulted in localized high-flux events in the arc, increased exhumation of the Cascade Crystalline Core, underplating of the Swakane Gneiss, and coarse-grained sedimentation across the basin. The data presented here provides added context for the evolution of the basin and provides insight into the protracted geodynamics of forearc basins undergoing oblique subduction.
Lifestyle and sociodemographic risk factors for gastroschisis: a systematic review and meta-analysis
Authors: Baldacci Silvia , Santoro Michele , Coi Alessio , Mezzasalma Lorena , Bianchi Fabrizio , Pierini Anna 
Published: February 2020

BackgroundGastroschisis is strongly associated with young maternal age. This association suggests the need for further investigations on non-genetic risk factors. Identifying these risk factors is a public health priority in order to develop prevention strategies aimed at reducing the prevalence and health consequences in offspring.ObjectiveTo systematically assess and quantitatively synthesise the available epidemiological studies to evaluate the association between non-genetic risk factors and gastroschisis.MethodsLiterature from PubMed, EMBASE and Scopus was searched for the period 1990–2018. Epidemiological studies reporting risk estimates between lifestyle and sociodemographic risk factors and gastroschisis were included. Two pairs of reviewers independently extracted information on study characteristics following Preferred Reporting Items for Systematic Reviews and Meta-Analyses and MOOSE (Meta-analysis Of Oservational Studies in Epidemiology) guidelines. Relative risk (RR) estimates were calculated across the studies and meta-analysis was performed using random-effects model.ResultsWe identified 58 studies. Meta-analyses were conducted on 29 studies. Maternal smoking (RR 1.56, 95% CI 1.40 to 1.74), illicit drug use (RR 2.14, 95% CI 1.48 to 3.07) and alcohol consumption (RR 1.40, 95% CI 1.13 to 1.70) were associated with an increased risk of gastroschisis. A decreased risk among black mothers compared with non-Hispanic white mothers (RR 0.49, 95% CI 0.38 to 0.63) was found. For Hispanic mothers no association was observed.ConclusionsExposure to smoking, illicit drugs and alcohol during pregnancy is associated with an increased risk of gastroschisis. A significantly decreased risk for black mothers was observed. Further epidemiological studies to assess the potential role of other environmental factors are strongly recommended.PROSPERO registration numberCRD42018104284.
Clinical characteristics of infective endocarditis in patients with antineutrophil cytoplasmic antibody or antiphospholipid antibody: a retrospective study in Shanghai
Authors: Zhou Zhuochao , Ye Junna , Teng Jialin , Liu Honglei , Cheng Xiaobing , Sun Yue , Su Yutong , Chi Huihui , Wang Fan , Yang Chengde , Jin Wei 
Published: February 2020

ObjectiveThis study aimed to characterise rheumatic manifestations and autoantibodies in 432 patients diagnosed with infective endocarditis (IE) in Shanghai.Design, setting and participantsA retrospective study was conducted in Ruijin Hospital from 1997 to 2017. The clinical and laboratory characteristics of a total of 432 patients were analysed. In addition, the differences between patients with positive and negative antineutrophil cytoplasmic antibodies (ANCA) and antiphospholipid (aPL) antibodies as well as the survival rates of these patients were compared.ResultsA total of 432 patients, including 278 male patients and 154 female patients, were included. The mean age of the patients was 46±16 years. A total of 346 patients (80%) had cardiac surgery, and 55 patients (13%) died in the hospital. Among the IE patients, 104 were tested for either ANCA or aPL and were analysed in different groups. Twenty-one (24%) positive ANCA patients were proteinase 3-ANCA positive. Compared with the ANCA-negative group, patients with positive ANCA had higher IgM (p=0.048), lower haemoglobin (p=0.001) and a higher likelihood of arthritis (p=0.003). Twenty-one (40%) aPL-positive patients had a higher erythrocyte sedimentation rate than was found in the aPL-negative group (p=0.003). In addition, the survival rate of the ANCA-positive IE patients was lower (p=0.032) than that of the ANCA-negative group, while there was no difference between patients with or without aPL antibodies (p=0.728).ConclusionThis study supports the claim that rheumatic manifestations and autoantibodies are frequently present in patients with IE and might lead to early misdiagnosis. Physicians should pay more attention to the measurement of autoantibodies in these patients.
Patient data-sharing for immigration enforcement: a qualitative study of healthcare providers in England
Authors: Papageorgiou Vasiliki , Wharton-Smith Alexandra , Campos-Matos Ines , Ward Helen 
Published: February 2020

AimTo explore healthcare providers’ perceptions and experiences of the implications of a patient data-sharing agreement between National Health Service (NHS) Digital and the Home Office on access to NHS services and quality of care received by migrant patients in England.DesignA qualitative study using semi-structured interviews, thematic analysis and constant-comparison approach.ParticipantsEleven healthcare providers and one non-clinical volunteer working in community or hospital-based settings who had experience of migrants accessing NHS England services. Interviews were carried out in 2018.SettingEngland.ResultsAwareness and understanding of the patient data-sharing agreement varied among participants, who associated this with a perceived lack of transparency by the government. Participants provided insight into how they thought the data-sharing agreement was negatively influencing migrants’ health-seeking behaviour, their relationship with clinicians and the safety and quality of their care. They referred to the policy as a challenge to their core ethical principles, explicitly patient confidentiality and trust, which varied depending on their clinical specialty.ConclusionsA perceived lack of transparency during the policy development process can result in suspicion or mistrust towards government among the health workforce, patients and public, which is underpinned by a notion of power or control. The patient data-sharing agreement was considered a threat to some of the core principles of the NHS and its implementation as adversely affecting healthcare access and patient safety. Future policy development should involve a range of stakeholders including civil society, healthcare professionals and ethicists, and include more meaningful assessments of the impact on healthcare and public health.
Effectiveness and harms of high-flow nasal oxygen (HFNO) for acute respiratory failure: a systematic review protocol
Authors: Baldomero Arianne K , Melzer Anne , Greer Nancy , Majeski Brittany N , Macdonald Roderick , Wilt Timothy J 
Published: February 2020

IntroductionHigh-flow nasal oxygen (HFNO) use in adults hospitalised with acute respiratory failure (ARF) is increasing. However, evidence to support widespread use of HFNO compared with non-invasive ventilation (NIV) and conventional oxygen therapy (COT) is unclear. This protocol describes the methods for a systematic evidence review regarding the comparative effectiveness and harms of HFNO compared with NIV or COT for the management of ARF in hospitalised adult patients.Methods and analysisWe will search MEDLINE, Embase, CINAHL and Cochrane Library for randomised-controlled trials (RCTs) of adult patients hospitalised with ARF or who developed ARF while hospitalised. ARF will be defined as SpO2<90%, PaO2:FiO2ratio ≤300, PaO2≤60 mm Hg, or PaCO2≥45 mm Hg. The intervention is HFNO (humidified oxygen, flow rate ≥20 L/min) compared separately to NIV or COT. The critical outcomes are: all-cause mortality, hospital-acquired pneumonia, intubation/reintubation (days of intubation), intensive care unit admission/transfers, patient comfort and hospital length of stay. The important outcomes are: delirium, 30-day hospital readmissions, barotrauma, compromised nutrition (enteral or parenteral nutrition), gastric dysfunction, functional independence at discharge and skin breakdown or pressure ulcers. We will calculate risk ratios and Peto ORs (for rare events) and corresponding 95% CIs for categorical outcomes. Mean and standardised mean difference will be calculated for continuous outcomes. Where possible and appropriate, meta-analysis will be performed for each outcome.ConclusionThis systematic review will provide a comprehensive evaluation of the evidence regarding the comparative effectiveness and harms of HFNO compared with NIV or COT for the management of ARF in hospitalised adult patients to inform clinical practice and to identify research gaps in the management of ARF in hospitalised adults. The results will inform the work of the American College of Physicians-Clinical Guidelines Committee in their development of a clinical guideline related to use of HFNO in adult patients with ARF.Ethics and disseminationNo ethical approval will be needed because we will be using data from previously published studies in which informed consent was obtained by the primary investigators. We will publish our results in a peer-reviewed journal.PROSPERO registration numberCRD42019146691
Individual factors associated with baseball pitching performance: scoping review
Authors: Mercier Marie-Andrée , Tremblay Mathieu , Daneau Catherine , Descarreaux Martin 
Published: February 2020

BackgroundBall velocity, accuracy and game statistics represent three methods used to measure pitching performance. However, individual determinants of pitching performance are more elusive.ObjectivesThe aims of this study were to classify the performance factors associated with baseball pitchers, to identify the methods used to quantify their abilities through all features of the game and to document relationships between performance factors and indicators.DesignScoping review.Data sourcesElectronic searches of MEDLINE, Academic Search Complete, CINAHL, SportDiscus, PubMed, PsycINFO, Cochrane and of grey literature were undertaken from inception to January 2019.Eligibility criteria for selecting studiesCross-sectional studies that investigated the relationship between performance indicators and individual performance factors in healthy baseball pitchers were selected.ResultsThirty-four cross-sectional studies investigating individual potential factors of pitching performance met the inclusion criteria. The primary performance factors investigated were kinematic, kinetic, timing outcomes, personal characteristics, physical tests and range of motion. Shoulder horizontal adduction (SHA), upper torso forward flexion, maximal shoulder external rotation, upper torso rotation angle, upper torso lateral flexion, lead knee flexion (LKF) and forward trunk tilt (FTT) were identified as key kinematic features associated with increased ball velocity. Shoulder proximal force and peak elbow proximal forces were associated with greater ball velocity. Individual performances in jumping tests and body weight (BW) are also associated with pitching performance.Summary/conclusionBased on studies presenting low and moderate risk of bias, we conclude that BW, age and kinematics, such as FTT, LKF, SHA and lateral trunk tilt, are associated with pitching performance.
Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer
Authors: Zhang Mingjie , Huang Lifeng , Ding Guoping , Huang Huilian , Cao Guoliang , Sun Xu , Lou Neng , Wei Qiang , Shen Tao , Xu Xiaodong , Cao Liping , Yan Qiang 
Published: February 2020

BackgroundPancreatic cancer (PC) is a common malignancy of the digestive system and is characterized by poor prognosis and early metastasis. Tumor immune escape plays an important role in PC progression. Programmed death 1 (PD1) blockade therapy is a promising treatment for patients with PC, but is yet to achieve significant clinical effects so far. Interferon gamma (IFN-γ) is a soluble dimeric cytokine that is closely associated with tumor immune surveillance and cytotoxicity. IFN-γ suppresses a variety of tumor-derived cytokines in PC, such as CXCL8. In the present study, we investigated the therapeutic efficacy of combined anti-PD1 and IFN-γ treatment in PC.MethodsBxPC-3 and Panc-1 human PC cell lines were used to construct a murine PC model. Blood samples (n=44) and surgical resection specimens (n=36) from human patients with PC were also collected. χ2test, two-tailed unpaired t-test or Kaplan-Meier survival analysis was used to calculate p values.ResultsPD1/PD-L1 signaling was overexpressed in PC tumor-bearing mice. Anti-PD1 prevented tumor growth if initiated early after tumor inoculation; however, delayed anti-PD1 treatment showed limited benefit. Murine PC model had a preferential expansion of CXCR2+CD68+macrophages, and these cells showed an immunosuppressive nature (M2 polarization). PC tumors overexpressed CXCL8 and tumor-derived CXCL8 deficiency prohibited the trafficking of CXCR2+CD68+macrophages. IFN-γ suppressed the expression of tumor-derived CXCL8, and combined with IFN-γ treatment, delayed anti-PD1 treatment showed significant antitumor effects. Thus, we conclude that murine CXCR2+CD68+macrophages traffic to PC tumors by tumor-derived CXCL8 and mediate local immunosuppression, which limits the efficacy of PD1 blockade therapy. IFN-γ suppresses tumor-derived CXCL8 and inhibits the tumor trafficking of CXCR2+CD68+macrophages by blocking the CXCL8–CXCR2 axis to enhance anti-PD1 efficacy. Human PC also produces high levels of CXCL8. Patients with PC present elevated CXCR2 expression on peripheral and tumor-infiltrating CD68+macrophages, which are associated with advanced tumor stage and poor prognosis.ConclusionOur findings suggest that IFN-γ is a translatable, therapeutic option to improve the efficacy of PD1 blockade therapy by preventing trafficking of CXCR2+CD68+macrophages via blocking the CXCL8–CXCR2 axis.