bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Analysis of Fresh Cheese Prepared Using Wrightia tinctoria Proteases
Authors: Rajagopalan Anusha , Sukumaran Bindhu O. 
Published: February 2020

Background:
Aqueous leaf extract of Wrightia tinctoria has been in use for artisanal
cheese preparation in diverse parts of India. Scientific validation behind the milk clotting potential of
W. tinctoria stem proteases purified through three-phase partitioning (TPP) has been attempted.
However, its contribution to cheese quality standards has not been tried yet.

Objective:
To evaluate the suitability of three-phase partitioned W. tinctoria (WT) stem proteases in
fresh cheese making.

Methods:
Fresh cheese was prepared using W. tinctoria TPP proteases and its characteristics were
compared with that of commercial plant milk coagulant, Enzeco® (CEz) and rennin (CRn). Yield, organoleptic
and textural properties, total fat, protein and moisture content of all cheese were determined
according to FSSAI standards. Toxicity of the TPP proteases was assessed on the shrimp
model (Artemia salina egg and Litopenaeus vannamei post-larval shrimps).

Results:
TPP proteases were found to be non-toxic and safe for human consumption with no change
in egg hatchability and survival of the shrimps in comparison to that of control. Cheese analysis results
indicated perceptible resemblance in nutritional characteristics of WT cheese with control
cheese. Yield, textural properties and organoleptic acceptance of WT cheese resembled more closely
with that of CEz cheese.

Conclusion:
Observation from the study paves the way for the acceptance of W. tinctoria proteases
as a suitable vegetable rennet for fresh cheese making.
Fatty Acid Profile and In Vitro Anticancer Activity of Two Marine Sponge- Associated Bacteria
Authors: Tommonaro Giuseppina , El-Hagrassi Ali M. , Fayad Walid , Iodice Carmine , Shaker Kamel H. , EL-Hady Faten K. Abd 
Published: February 2020

Background:
Colorectal cancer represents one of the prominent causes of mortality worldwide
in men and women. The objective of this study was to search for new potential anticancer compounds,
both in prevention and treatment of colorectal cancer. The anticancer potential of marine bacterial
extracts against Human colorectal carcinoma cell line (HCT116) was evaluated as well as the partial
identification of bioactive metabolites.

Methods:
All bacterial extracts were tested for their cytotoxicity against HCT116 cell line by means of
MTT assay. The highly cytotoxic dichloromethane extracts of marine sponge-associated bacteria Vibrio
sp. and Bacillus sp. were analyzed by GC-MS.

Results:
Two fractions, Vib3 and Bac3, exhibited a very interesting cytotoxicity against human colorectal
carcinoma (HCT116) cell line, with a percentage of cytotoxicity of 96.04 % and 29.48 %, respectively.

Discussion:
The GC-MS analysis revealed the presence of two major fatty acids, palmitic and oleic
acids, in Vib3 fraction and fatty acid esters and phenolic compounds in Bac3 fraction.

Conclusion:
Based on previous literature, it may be hypothesized that the anticancer activity of
bacterial extracts could be, at least partially, to the fatty acids fraction.
The Association between HbA1c Levels, Olfactory Memory and Cognition in Normal, Pre-Diabetic and Diabetic Persons
Authors: Yulug Burak , Saatci Ozlem , Işıklar Aysun , Hanoglu Lutfu , Kilic Ulkan , Ozansoy Mehmet , Cankaya Seyda , Cankaya Baris , Kilic Ertugrul 
Published: February 2020

Background and Aim:Recent data have shown that olfactory dysfunction is strongly related to Alzheimer’s Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an early indicator of future cognitive in prediabetes.Methods:We have applied to a group of normal (n=15), prediabetic (n=16) and type 2 diabetic outpatients (n=15) olfactory testing, 1.5-T MRI scanner and detailed cognitive evaluation including the standard Mini-Mental State Examination (MMSE) form, Short Blessed Test (SBT), Letter Fluency Test (LFT) and the category fluency test with animal, Fruit and Vegetable Naming (CFT).Results:We have shown that Odour Threshold (OT), Discrimination (OD), and Identification (OI) scores and most cognitive test results were significantly different in the prediabetes and diabetes group compared to those in the control group. OD and OT were significantly different between the prediabetes and diabetes group, although the cognitive test results were only significantly different in the prediabetes and diabetes group compared to those in the control group. In evaluating the association between OI, OT, OD scores and specific cognitive tests, we have found, that impaired olfactory identification was the only parameter that correlated significantly with the SBT both in the pre-diabetes and diabetes group. Although spot glucose values were only correlated with OT, HbA1c levels were correlated with OT, OD, and OI, as well as results of the letter fluency test suggesting that HbA1c levels rather than the spot glucose values play a critical role in specific cognitive dysfunction.Conclusion:To the best of our knowledge, this is the first prospective study to demonstrate a strong association between olfactory dysfunction and specific memory impairment in a population with prediabetes and diabetes suggesting that impaired olfactory identification might play an important role as a specific predictor of memory decline.
Design of a Management Algorithm for Energy Trading in Microgrids
Authors: Verginadis Dimosthenis , Karlis Athanasios 
Published: February 2020

Background:
The scope of this paper is to study the energy trading in microgrids. Microgrids
are low voltage or medium voltage distribution networks, which consist of energy storage
systems, electric loads, e.g. electric vehicles and Renewable Energy Sources (RES).

Methods:
Legacy energy grids are being transformed by the introduction of small to medium sized
individual or cooperative, mostly RES invested energy producers and prosumers. Electric vehicles
penetrate the market and modern power grids integrate them as ancillary services providers when
there are peak domestic loads, as well as in order to balance grid voltage aiming to increase system
reliability, compensating for renewable energy sources’ intermittency and volatility in energy production.

Results:
An elaborate management algorithm is proposed in this paper, to balance demand and local
renewable energy sources microgrid supply.

Conclusion:
Finally, the results of simulations of different scenarios, including economic parameters
and proposals for future research are presented.
THE EFFECT OF LEVERAGE, BOARD OF DIRECTORS, AUDIT COMMITTEE AND COMPANY SIZE ON THE LEVEL OF HEALTH FINANCIAL PERFORMANCE
Authors: Utami Martiana Riawati , Priantinah Denies 
Published: February 2020

Abstract : The Effect Of Leverage, Board Of Directors, Audit Committee And Company Size On The Level Of Health Financial Performance. This research aims to analyze (1) the effect of Leverage on the Level of Health Financial Performance, (2) the effect of Board of Directors on the Level of Health Financial Performance, (3) the effect of Audit Committee on the Level of Health Financial Performance, (4) the effect of Company Size on the Level of Health Financial Performance, and (5) the effect of Leverage, Board of Directors, Audit Committee and Company Size simultaneously on the Level of Health Financial Performance. This research was a causal research. The population of this research are manufacturing companies listed in Indonesia Stock Exchange period 2014-2016. A purposive sampling method was used as a sampling method and 96 companies were selected as sample of research. The data analysis techniques were simple linear regression analysis and multiple linear regression analysis. The result of this research indicates that (1) Leverage has a positive effect on the Level of Health Financial Performance, (2) Board of Directors has a positive effect on the Level of Health Financial Performance, (3) Audit Committee has a positive effect on the Level of Health Financial Performance, (4) Company Size has a positive effect on the Level of Health Financial Performance, and (5) Leverage, Board of Directots, Audit Committee and Company Size simultaneously has a positive effect on the Level of Health Financial Performance. Keywords: Level of Health Financial Performance, Leverage, Board of Directors, Audit Committee, Company Size
Learning Latent Space Representations to Predict Patient Outcomes: Model Development and Validation
Authors: Rongali Subendhu , Rose Adam J , McManus David D , Bajracharya Adarsha S , Kapoor Alok , Granillo Edgard , Yu Hong 
Published: February 2020

Background
Scalable and accurate health outcome prediction using electronic health record (EHR) data has gained much attention in research recently. Previous machine learning models mostly ignore relations between different types of clinical data (ie, laboratory components, International Classification of Diseases codes, and medications).

Objective
This study aimed to model such relations and build predictive models using the EHR data from intensive care units. We developed innovative neural network models and compared them with the widely used logistic regression model and other state-of-the-art neural network models to predict the patient’s mortality using their longitudinal EHR data.

Methods
We built a set of neural network models that we collectively called as long short-term memory (LSTM) outcome prediction using comprehensive feature relations or in short, CLOUT. Our CLOUT models use a correlational neural network model to identify a latent space representation between different types of discrete clinical features during a patient’s encounter and integrate the latent representation into an LSTM-based predictive model framework. In addition, we designed an ablation experiment to identify risk factors from our CLOUT models. Using physicians’ input as the gold standard, we compared the risk factors identified by both CLOUT and logistic regression models.

Results
Experiments on the Medical Information Mart for Intensive Care-III dataset (selected patient population: 7537) show that CLOUT (area under the receiver operating characteristic curve=0.89) has surpassed logistic regression (0.82) and other baseline NN models (<0.86). In addition, physicians’ agreement with the CLOUT-derived risk factor rankings was statistically significantly higher than the agreement with the logistic regression model.

Conclusions
Our results support the applicability of CLOUT for real-world clinical use in identifying patients at high risk of mortality.
Teamwork and Safety Attitudes in Complex Aortic Surgery at a Dutch Hospital: Cross-Sectional Survey Study
Authors: Hilt Alexander D , Kaptein Ad A , Schalij Martin J , van Schaik Jan 
Published: February 2020

Background
Improving teamwork in surgery is a complex goal and difficult to achieve. Human factors questionnaires, such as the Safety Attitudes Questionnaire (SAQ), can help us understand medical teamwork and may assist in achieving this goal.

Objective
This paper aimed to assess local team and safety culture in a cardiovascular surgery setting to understand how purposeful teamwork improvements can be reached.

Methods
Two cardiovascular surgical teams performing complex aortic treatments were assessed: an endovascular-treatment team (ETT) and an open-treatment team (OTT). Both teams answered an online version of the SAQ Dutch Edition (SAQ-NL) consisting of 30 questions related to six different domains of safety: teamwork climate, safety climate, job satisfaction, stress recognition, perceptions of management, and working conditions. In addition, one open-ended question was posed to gain more insight into the completed questionnaires.

Results
The SAQ-NL was completed by all 23 ETT members and all 13 OTT members. Team composition was comparable for both teams: 57% and 62% males, respectively, and 48% and 54% physicians, respectively. All participants worked for 10 years or more in health care. SAQ-NL mean scores were comparable between both teams, with important differences found between the physicians and nonphysicians of the ETT. Nonphysicians were less positive about the safety climate, job satisfaction, and working climate domains than were the physicians (P<.05). Additional education on performed procedures, more conjoined team training, as well as a hybrid operating room were suggested by participants as important areas of improvement.

Conclusions
Nonphysicians of a local team performing complex endovascular aortic aneurysm surgery perceived safety climate, job satisfaction, and working conditions less positively than did physicians from the same team. Open-ended questions suggested that this is related to a lack of adequate conjoined training, lack of adequate education, and lack of an adequate operating room. With added open-ended questions, the SAQ-NL appears to be an assessment tool that allows for developing strategies that are instrumental in improving quality of care.
Gambaran Kadar Bilirubin Total pada Penderita Tuberkulosis Paru dengan Terapi Obat Anti Tuberkulosis (Oat) di Puskesmas Poasia Kota Kendari
Authors: Firdayanti Firdayanti 
Published: February 2020

Background: Treatment of tuberculosis by using anti-tuberculosis drugs (OAT) can be accepted in therapy, but has potential effectiveness such as side effects of hematologic reactions, namely anemia, agranulocytosis, eosinophilia and thrombocytopenia, and liver function. Hyperbilirubinemia is one of the side effects of using OAT which is often complained by patients.Objective: to determine the description of total bilirubin levels in tuberculosis patients with OAT therapy at the Poasia Health Center in Kendari CityMethod: This study was descriptive with bilirubin examination using the Jendrassik-Grof method by spectrophotometer. Total bilirubin examination was performed on 18 pulmonary tuberculosis patients who received OAT therapy at the Poasia Health Center in Kendari City.Results: The results of the study showed that from 18 samples examined, there were 10 samples with high bilirubin levels (hyperbilirubinemia) and 8 samples had normal bilirubin levels.Conclusion: Total bilirubin levels in patients with pulmonary tuberculosis with OAT therapy were found as many as 10 patients had high bilirubin levels (hyperbilirubinemia) and 8 patients had normal bilirubin levels. Keywords: Bilirubin, Hyperbilirubinemia, OAT, Therapy, Tuberculosis
Asupan Zat Besi, Asam Folat, dan Vitamin C pada Remaja Putri di Daerah Jatinangor
Authors: Azizah Dini Izmi 
Published: February 2020

Latar Belakang: Masa remaja merupakan masa yang rentan terjadinya anemia dikarenakan cenderung mengalami kekurangan asupan gizi yang dibutuhkan oleh tubuh terutama zat besi, asam folat, dan vitamin C. Tujuan penelitian ini adalah untuk mengetahui rerata dan proporsi kecukupan asupan zat besi, asam folat, dan vitamin C pada remaja putri di Kecamatan Jatinangor.Metode: Metode penelitian deskriptif dengan pendekatan potong lintang pada remaja putri usia 10-19 tahun periode Juni-Agustus 2018. Data asupan gizi diperoleh melalui 3 day-food record dan dilakukan follow up melalui Whatsapp Group, kemudian dilakukan konversi ukuran makanan dari bentuk Ukuran Rumah Tangga menjadi gram melalui buku foto makanan. Setelah itu, dimasukkan kedalam aplikasi nutrisurvey untuk dihitung kandungan asupan gizi dan dirata-ratakan serta dibandingkan dengan Angka Kecukupan Gizi yang direkomendasikan oleh Permenkes.Hasil: Penelitian ini menunjukkan bahwa rerata asupan zat besi sebesar 10,67 mg/hari, dimana responden yang tidak memenuhi kecukupan zat besi sebesar 93,6% (88 orang). Rerata asupan asam folat sebesar 180,67 μg/hari, dimana sebagian besar responden tidak memenuhi kecukupan asam folat mencapai 94,7% (89 orang). Rerata asupan vitamin C pada penelitian ini sebesar 29,71 mg/hari dimana sebagian besar responden tidak memenuhi kecukupan vitamin C yaitu sebesar 67% (63 orang).Kesimpulan: Rerata asupan zat besi, asam folat, dan vitamin C remaja putri dibawah standar AKG dan tidak memenuhi AKG yang direkomendasikan. Hal ini dikarenakan jenis bahan makanan yang dikonsumsi remaja tidak bervariasi. Untuk memperbaiki asupan gizi dan status gizi remaja antara lain perlu upaya peningkatan pengetahuan gizi, salah satunya melalui pendidikan gizi.
Confección de un archivo digital de revistas femeninas de la década del ‘60 en Argentina
Authors: Schaufler María Laura 
Published: February 2020

Resumen
El artículo presenta un marco conceptual-metodológico y da cuenta de una experiencia de confección de un archivo digital de cultura de masas, específicamente de revistas de la década del ‘60. Estos materiales forman parte de la historia cultural y corren el riesgo de perderse si no se realiza un esfuerzo por recuperarlos. El trabajo se asienta en la experiencia de la Acción de Extensión de la Facultad de Ciencias de la Educación, Universidad Nacional de Entre Ríos: “Archivo Hemerográfico: Géneros y sexualidades en revistas de la década del ‘60 en Argentina”.
El texto apunta a repensar la vinculación entre historia cultural, investigación social, enseñanza y extensión, a partir del uso y la confección de archivos tras la experiencia de organización de un reservorio cultural y banco de conocimientos accesible, inexistente en las bibliotecas de la región. El trabajo tiene como antecedente la investigación doctoral “La construcción del erotismo en revistas femeninas de la década del ‘60 en Argentina” (SCHAUFLER, 2015) y sistematiza y extiende uno de sus resultados referido a la confección de un extenso corpus de artículos de revistas de la década referidos a tópicos como la feminidad, el feminismo, el amor, la sexualidad, la educación sexual, el deseo y el placer erótico, los cuerpos, cruciales para investigaciones contemporáneas en estudios culturales, comunicación y cultura y estudios de géneros.
Palabras clave: Revistas femeninas. Sesenta. Archivos.

Resumo
O artigo apresenta um arcabouço conceitual-metodológico e dá a experiência de fazer um arquivo digital de cultura de massa, especificamente de revistas dos anos 60. Estes materiais fazem parte da história cultural e correm o risco de se perderem se não se fizer um esforço para os recuperar. O trabalho assenta na experiência da Ação de Extensão da Faculdade de Ciências da Educação, Universidade Nacional de Entre Ríos: “Arquivo Hemerográfico: gêneros e sexualidades em revistas da década do ‘60 na Argentina”. O texto visa repensar a relação entre história cultural, pesquisa social, ensino e extensão, a partir do uso e da confecção de arquivos após a experiência de organização de um reservatório cultural e banco de conhecimentos acessível, inexistente nas bibliotecas da região. O trabalho tem como antecedente a pesquisa doutoral A construção do erotismo em revistas femininas da década do ‘60 na Argentina” (SCHAUFLER, 2015) e sistematiza e estende um dos seus resultados referente à confecção de um extenso corpus de artigos de revistas da década referidos a tópicos como a feminilidade, o feminismo, o amor, a sexualidade, a educação sexual, desejo e prazer erótico, corpos, cruciais para pesquisas contemporâneas em estudos culturais, comunicação e cultura e estudos de gênero.
Palavras chave: Revistas Femininas. Sessenta. Arquivos.
O Corpus Tycho Brahe: um corpus sintaticamente anotado do português histórico
Authors: Galves Charlotte 
Published: February 2020

Este artigo apresenta a metodologia de trabalho de construção e uso do Corpus Sintaticamente Anotado do Português Histórico Tycho Brahe. Descreve a ferramenta de edição eletrônica eDictor, bem como o sistema de etiquetagem de palavras e de anotação sintática aplicado aos textos. Exemplifica o funcionamento e uso da linguagem de busca Corpus Search, que procura construções em arquivos sintaticamente anotados, a partir de perguntas de pesquisa. Mostra os avanços da pesquisa sobre a história do português europeu permitidos pela grande quantidade de dados anotados disponíveis no Corpus Tycho Brahe para o período dos séculos 16 a 19. Na conclusão, evoca-se a extensão do trabalho ao português brasileiro, a favor da convergência entre a metodologia proposta e o trabalho intensivo de edição de documentos históricos de diversas procedências socio-culturais e geográficas.
Palavras-chave: Corpus Tycho Brahe. Anotação sintática. História do português. Português brasileiro.

Resumen
Este artículo presenta la metodología de trabajo de construcción y uso del Corpus Sintácticamente Anotado del Português Histórico Tycho Brahe. Describe la herramienta de edición electrónica eDictor, así como el sistema de etiquetado de palabras y anotación sintáctica aplicada a los textos. Ejemplifica el funcionamiento y el uso del lenguaje de búsqueda Corpus Search, que busca construcciones en archivos sintácticamente anotados, a partir de preguntas de investigación. Muestra los avances de la investigación sobre la historia del portugués europeo permitidos por la gran cantidad de datos anotados disponibles en el Corpus Tycho Brahe para el período comprendido entre los siglos XVI y XIX. En la conclusión, se evoca la extensión del trabajo al portugués brasileño, a favor de la convergencia entre la metodología propuesta y el intenso trabajo de edición de documentos históricos de diversas procedencias socioculturales y geográficas.
Palabras clave: Corpus Tycho Brahe. Anotación sintáctica. Historia del portugués. Portugués brasileño.
Alcances y desafíos de un proyecto de divulgación
Authors: Fernández Sandra , Ferragutti Guillermo , Yunis Micaela 
Published: February 2020

Resumen
El presente trabajo se propone presentar los alcances y desafíos que implicó la construcción, diseño y difusión del Archivo Visual de la Sociabilidad Santafesina (1920-1960), proyecto de divulgación elegido y subsidiado desde 2014 por la Secretaría de Estado de Ciencia y Tecnología de la Provincia de Santa Fe en vinculación con Investigaciones Socio-históricas Regionales (ISHIR-CONICET/UNR). La originalidad de la propuesta radicó en la puesta en valor de fotografías, cedidas temporalmente por ciudadanos de la provincia, en las que se representaran las distintas manifestaciones de la sociabilidad formal e informal, su reproducción digital y su almacenamiento en un soporte online de acceso abierto, libre y gratuito.
Palabras clave: Archivo visual. Fotografía. Sociabilidad. Santa Fe. Acceso Abierto.
Resumo
O presente trabalho tem como objetivo apresentar o escopo e desafíos envolvidos na construção, projeto e divulgação do Arquivo Visual da Sociabilidade Santafesina (1920-1960), projeto de divulgação escolhido e subsidiado, desde 2014, pela Secretaria Estadual de Ciência e Tecnologia da Província de Santa Fe. Santa Fe, vinculada à Investigações Sócio-históricas Regionais (ISHIR-CONICET/UNR). A originalidade da proposta reside na valorização de fotografias, cedidas temporariamente por cidadãos da província, nas quais estão representadas as diferentes manifestações da sociabilidade formal e informal, sua reprodução digital e armazenamento em um suporte on line de Open Access, livre e gratuito.
Palavras chave: Arquivo visual. Fotografia. Sociabilidade. Santa Fe. Open Access.