bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blockade of the G-CSF Receptor Is Protective in a Mouse Model of Renal Ischemia–Reperfusion Injury
Authors: McRae Jennifer L. , Vikstrom Ingela B. , Bongoni Anjan K. , Salvaris Evelyn J. , Fisicaro Nella , Ng Milica , Alhamdoosh Monther , Baz Morelli Adriana , Cowan Peter J. , Pearse Martin J. 
Published: August 2020

AbstractIschemia–reperfusion injury (IRI) is a complex inflammatory process that detrimentally affects the function of transplanted organs. Neutrophils are important contributors to the pathogenesis of renal IRI. Signaling by G-CSF, a regulator of neutrophil development, trafficking, and function, plays a key role in several neutrophil-associated inflammatory disease models. In this study, we investigated whether targeting neutrophils with a neutralizing mAb to G-CSFR would reduce inflammation and protect against injury in a mouse model of warm renal IRI. Mice were treated with anti–G-CSFR 24 h prior to 22-min unilateral renal ischemia. Renal function and histology, complement activation, and expression of kidney injury markers, and inflammatory mediators were assessed 24 h after reperfusion. Treatment with anti–G-CSFR protected against renal IRI in a dose-dependent manner, significantly reducing serum creatinine and urea, tubular injury, neutrophil and macrophage infiltration, and complement activation (plasma C5a) and deposition (tissue C9). Renal expression of several proinflammatory genes (CXCL1/KC, CXCL2/MIP-2, MCP-1/CCL2, CXCR2, IL-6, ICAM-1, P-selectin, and C5aR) was suppressed by anti–G-CSFR, as was the level of circulating P-selectin and ICAM-1. Neutrophils in anti–G-CSFR–treated mice displayed lower levels of the chemokine receptor CXCR2, consistent with a reduced ability to traffic to inflammatory sites. Furthermore, whole transcriptome analysis using RNA sequencing showed that gene expression changes in IRI kidneys after anti–G-CSFR treatment were indistinguishable from sham-operated kidneys without IRI. Hence, anti–G-CSFR treatment prevented the development of IRI in the kidneys. Our results suggest G-CSFR blockade as a promising therapeutic approach to attenuate renal IRI.
Diplomasi Tingkat Tinggi: Sebuah Pemahaman Awal
Authors: Zulkarnain Zulkarnain 
Published: August 2020

<p><strong><em>Abstract</em></strong></p><p><em>Summit</em><em> diplomacy belongs to the head of state or head of government. It will happen when there are crucial problems faced by the countries concerned and directly touch the collective interests of two or more countries involved in the summit. </em><em>Summit or h</em><em>igh-level diplomacy is also a reflection of a quick response by the parties that tends to produce a weighted agenda, so high-level diplomacy is not a series of activities of heads of state or heads of government filled with imaging missions, but rather an important mission for the national interest. One of the most important things of high-level diplomacy is the "ideology" of high-level diplomacy itself, namely the preparation of strategies, coordination and implementation measures aimed at the achievement of targets and objectives. That way, </em><em>summit</em><em> diplomacy avoids the blowing winds that pass without meaningful impression to mankind.</em><em></em></p><p> </p><p><em>Key words : diplomacy, summit diplomacy, national interest</em></p>
ANALISIS DIPLOMASI INDONESIA – MALAYSIA DALAM MASALAH PERBATASAN
Authors: Sulaeman Achdijat 
Published: August 2020

<p><strong><em>Abstract</em></strong></p><p><em>The main function of diplomacy is to protect and promote national identity in this article will discuss the analysis of Indonesia and Malaysia diplomacy in border disputes, This will be examined by looking at the international relations which is then reviewed also the advantages and disadvantages seen in terms of policies and efforts made by the government for domestic and foreign purposes. Therefore, in this section the various studies of International Relations policy as well as activities of Indonesian society and Malaysia are the nation of one Malay family and the majority of the population are Muslim. Always between these two countries stumble stones like some cases of migrant workers, the loss of the two islands Sipadan Ligitan, the case on the Ambalat border, the Indonesian lndonesian tracking in Malaysia, the claiming of the Reog culture, the Batik, the Rasa Sayange song and a series of problems will become a common thread when dith retreats into the eyeglasses of the past.</em></p><p><em> </em></p><p><strong><em>Key Words :</em></strong><em> Diplomacy,Conflict, Negotiation, Mediation, Conciliation</em><strong></strong></p>
MENGUPAYAKAN KEMBALI EKSISTENSI IDEOLOGI PANCASILA
Authors: Efriza Efriza 
Published: August 2020

<p align="center"><em>ABSTRACT</em></p><p><em>This paper attempts to analyze the development of thinking and also responds to efforts to re-establish the existence of Pancasila Ideology as a common ideology. The government's efforts also demonstrate the shared desire of nationalism, democracy, and the ideology of Pancasila together. Pancasila ideology's unconscious awareness is an attempt to foster a sense of nationalism.</em><em></em></p><p> </p><pre><em>Keywords: </em><em>Pancasila Ideology</em>, <em>Nationalism</em><em>, </em><em>Democracy,</em></pre>
PROPAGANDA: AHOK TIDAK PANTAS JADI GUBERNUR
Authors: Prakosa Adi 
Published: August 2020

<p>Independent press and objective news are the rules. But on the news "Chairman of DPW Gerindra DKI: Ahok Enggak Indonesia Banget", in news published by Republika.co.id on Wednesday, July 27, 2016 edition, normative things that are violated. This is the reason to review the discourse submitted by Republika on line. The research method uses discourse analysis of Fairlcloud model. The theory used as a reference is Critical Theory. The results show that the news reviewed represents Ahok inappropriate to be governor. There are propaganda techniques applied, namely the name calling, card staking, and testimonials.</p><p>Keywords: press, news, discourse analysis</p>
MAHATMA GANDHI DAN GERAKAN PEREMPUAN DI INDIA
Authors: Salim Kamaruddin 
Published: August 2020

<p><em>Ahimsa and Satyagraha were the culmination of Gandhi's struggle. Ahimsa and Satyagraha combine short-term goals with long-term perspectives, more importantly Satyagraha proves the correctness of his method to unite theory with ways of social movement abstinence from violence. Satyagraha proved the strength of the Gandhi method to penetrate the people even though in agrarian areas that were socially and politically underdeveloped, and methods for carrying out a collective approach and education of social movements for women. This is a strategy to instill discipline and active involvement of women in socio-political and economic movements in India. For Gandhi, the involvement of women was an honorable activity for them.</em></p><p><em> </em></p><p><em>Keywords: Ahimsa,</em><em> Satyagraha, and social movements for women</em></p>
PENGARUH DIKLAT DAN KOMITMEN ORGANISASI TERHADAP KOMPETENSI DAN IMPLIKASINYA KEPADA KINERJA PEGAWA BIRO KESEKRETARIATAN PIMPINAN DEWAN PERWAKILAN RAKYAT REPUBLIK INDONESIA TAHUN 2018
Authors: Guridno Aberar , Sinambela Lijan Poltak 
Published: August 2020

<p>This study aims to analyze the effect of training and organizational commitment variables on competencies and their implications for the performance of employees of the Secretariat General of the House of Representatives of the Republic of Indonesia in 2018. The data were collected from the distribution of questionnaires to 125 bureau employees as respondents. The research model developed consisted of 2 independent variables and 1 dependent variable and 1 also intermediary variable (intervention) with 7 hypotheses to be tested.</p><p>Tests are carried out using SEM (Structural Equation Modeling) through the Analysis of Moment Structures Program (AMOS V.22) with 125 respondents, namely employees of the Secretariat General of the DPR RI Secretariat.</p><p>The results of this study indicate that the training variable has a significant and positive effect on competence with a CR value of 5.830 &gt; 1.96 and probability values &lt; 0.05, organizational commitment variables do not have a positive and real effect on competencies with a CR value of -1.314 &lt; 1.96 and a probability value of 0.189 &gt; 0.05, the competency variable does not have a positive and significant effect on employee performance with CR value is -5.449 &lt; 1.96 and probability value is 0.000 &lt; 0.05, the training variable has a positive and real effect on employee performance with a CR value of 5.927 &gt; 1.96 and probability values &lt; 0.05, organizational commitment variables have a positive effect and real performance of employees with a CR value of 6.053 &gt; 1.96 and probability values &lt; 0.05, training and competency variables through competence do not have a positive and real effect on employee performance with CR &gt; 1.96 probability values &lt; 0.05 but regression coefficients indirect effects of -1.166 and organizational commitment variables through competency positive and real effect on employee performance with a value of CR &gt; 1.96 and a probability value of &lt; 0.05 and a regression coefficient of positive indirect effect of 0.218.</p><p> </p><p><strong>Keyword</strong> : Training, Organizational Commitment, Competencies, Employee Performance, Hous of Representatives</p>
Repeated absolute gravity measurements on a dense network at Campi Flegrei – a reliable tool for volcano monitoring
Authors: Berrino Giovanna , Ricciardi Giuseppe 
Published: August 2020

Abstract. Since 1981, relative gravity measurements have routinely carried out at the Campi Flegrei caldera, a densely populated area. The gravity network also includes two absolute stations periodically measured with a laboratory absolute gravimeter, which does not permit field measurements. At the end of 2014, the Osservatorio Vesuviano, Section of Napoli of the Istituto Nazionale di Geofisica e Vulcanologia (INGV-OV), acquired a portable absolute gravimeter that allows field operations on outdoor sites. Therefore, in 2015 a dense absolute gravity network was established in Campi Flegrei. This will permit an advanced approach for volcano monitoring. The net consists of 36 stations, 34 of which located inside the caldera and placed upon or very close to gravity stations belonging to the relative network. Five surveys were carried out on June 2015, on February and November 2017, on October 2018 and on October 2019. The comparison with height changes suggests that significant Δg are partly due to the uplift occurred over the same time intervals and mostly to shallow processes associated to the dynamic of the local hydrothermal system. The comparison with the gradients observed during the last large uplift (1982–1984) and the following subsidence (1985–2003) confirms this observation. These results suggest that the present activity may be due to a transient or pulsating phenomenon as the alternating recharge/discharge of fluids in the surface hydrothermal system. Gravity changes detected by absolute measurements are in good agreement with those obtained by relative ones, and confirms the feasibility of this methodology for volcano monitoring. Finally, they also encourage replacing the relative networks with absolute ones, with all the consequent advantages.
Envisioning Indigenous Models for Social and Ecological Change in the Anthropocene
Authors: Fenelon James , Alford Jennifer 
Published: August 2020

Indigenous societies provide alternatives to hegemonic social institutions that global capitalism spread around the world, contributing to human caused environmental degradation called the Anthropocene, coterminous with the development of the modern world-system. In this work we describe Indigenous communities using ten social spheres, that balance human needs through ecological mindfulness, including spirituality, and then we model how these social spheres can be adapted to contemporary world-systems using a radical imaginary, building off Indigenous works by Fenelon (2015; 2016), social perspectives of Pellow (2017) and Norgaard (2019), and environmental geospatial sciences (Lui, Springer, and Wagner 2008; Jankowski 2009). We identify four social constructs from Indigenous peoples—(1) decision-making, (2) land tenure and resource management, (3) economic and (4) community—which we model for societies in world-systems through the ten imagined social spheres, to present foundations that empower communities to resist the coming climate change futures of the Anthropocene.
Se eu digo que emudeci, nada do que eu digo estou dizendo: aspectos do diálogo entre homem e Deus em "Floema", de Hilda Hist
Authors: Sippel Juliano 
Published: August 2020

Neste artigo analiso as categorias de tempo (SINHA; GÄRDENFORS, 2014) e aspecto (DAHL, 1985), nomeadamente aspectos do pretérito perfeito do indicativo (TRAVAGLIA, 2016; CAMPOS, 1997; CAMPOS, XAVIER, 1991) do presente do indicativo (TRAVAGLIA, 2016), do gerúndio e da perífrase estar + gerúndio (MENDES, 2005), no texto Floema de Hilda Hilst (2003). Nesse texto a autora desenvolve um diálogo entre um homem (Koyo) e um Deus (Haydum), que se materializa à sua frente. À medida que a narrativa avança, o que se observa é a representação da impossibilidade de se estabelecer comunicação direta entre Homem e divindade. Em meio a essa inviabilidade de conversa, ao analisar alguns eventos desse texto como categorias aspectuais (acabadas, não acabadas, cursivas, durativas, perfectivas, imperfectivas), procuro sistematizá-los em momentos específicos, na tentativa de encontrar uma organização textual/discursiva do confronto que ali se apresenta.
Mettre en oeuvre le consentement préalable, libre et éclairé (CPLE) en Eeyou Istchee
Authors: Bourgeois Sabrina , Rodon Thierry 
Published: August 2020

Le projet d’uranium Matoush de Ressources Strateco était promu par le gouvernement Charest, notamment dans le Plan Nord ; cependant, il n’était pas acceptable pour la communauté crie de Mistissini qui a obtenu l’appui du Grand Conseil des Cris d’Eeyou Istchee. Cet article documente la mobilisation de la norme du CPLE (Consentement préalable, libre et éclairé) par les Cris dans leur opposition au projet. Les auteurs montrent qu’en bloquant le projet Matoush, les Cris ont su créer un contexte politique favorable au respect de leur consentement sur la gestion des activités extractives, comme la politique minière crie l’indique clairement. Ils mettent ainsi en oeuvre le CPLE prévu par la Déclaration des Nations unies sur les droits des peuples autochtones et ce, même si le Canada ne l’a pas encore mise en oeuvre dans ses législations.
Redescription of the suspended aquatic Utricularia aurea Lour. (sect. Utricularia) and a new species U. adamsii for northern Australia
Authors: Jobson Richard W , Davies-Colley Taylor 
Published: August 2020

Australia has seven species in Utricularia L. section Utricularia, with the habit for all members of either affixed or suspended aquatic. Of the six recognised Australian species, one is endemic, one is pantropical, three are also distributed across Asia or Papua New Guinea - with U. australis R.Br. extending into Europe, and one other, U. stellaris L.f. into Africa. We present a molecular phylogeny based on two plastid and the nuclear ITS sequences for members of the subgenus Utricularia representing U. aurea Lour. and closely allied species from across each of their distributions. The molecular phylogeny provides strong support for recognition of a new species Utricularia adamsii R.W.Jobson & Davies-Colley (Lentibulariaceae), here described as new member
of section Utricularia. This taxon was previously included within U. aurea, however, our molecular phylogeny and morphology supports a sister relationship with U. muelleri Kamienski. We provide a revised concept of
U. aurea, and a description of the new species. The morphological differences between U. adamsii, U. muelleri, U. aurea and closely related species are here discussed, and an identification key provided. Distributions and
habitat preferences of these taxa are discussed.
Assessment of the Anti-proliferative Effect and Preliminary Analysis of Cell Cycle Arrest and Pro-apoptotic Effects of Balanites aegyptiaca (L.) Delile on Colorectal Cancer Cells HCT-116 and HT-29
Authors: Sawadogo Wamtinga Richard , Luo Yun , Elkington Bethany , He Tong-Chuan , Wang Chong-Zhi , Yuan Chun-Su 
Published: August 2020

Balanites aegyptiaca (L.) Delile (Zygophyllaceae), is used in traditional medicine for the treatment of intestinal worms, wounds, and inflammatory diseases. The purpose of this study is to assess the anti-proliferative effect and to analyse the pro-apoptotic and cell cycle arrest activities of B. aegyptiaca root bark extract and fractions against colorectal cancer cells HCT-116 and HT-29. The cytotoxicity of the crude extract and fractions were evaluated by MTS assay. The most active fractionwas subjected to crystal violet assay, Hoechst staining, cell cycle arrest, and annexin V/PI assays on cancer cells to highlight its mechanisms of action. The ethyl acetate fraction demonstrated the most cytotoxic effect on HCT-116 and HT-29 with IC50 values ranging between 3 and 4 µg/mL. At 10 µg/mL in the cell cycle arrest assay, the fraction increased G1 phase by 3.83% on HCT-116 and by 8.6% on HT-29 whilst G2/M phase was decreased by 5.63% on HCT-116 and by 6.62% on HT-29. Moreover, apoptotic cells were increased by 11.4% on HCT-116. The results suggest a potential source of anticancer molecules against colorectal cancer for isolation from the ethyl acetate fraction.
Comparative Study of Anterior Chamber Angle and Depth Recorded with Pentacam and AS-OCT SD “Spectralis”
Authors: Pateras E. , Morogiannis N. 
Published: August 2020

Aims: To compare the anterior chamber angle values recorded by Pentacam and AS-OCT SD “Spectralis” (Heidelberg Engineering) and present the correlation between the two devices.
Sample and Study Design: A total of 50 patients were examined at the Private Ophthalmology Clinic O.M.M.A. Ophthalmological Institute. All participants volunteer to participate in this study where the data was kept anonymous. Patients aged 18-45 years without a pathological history were selected. All of them were emmetropes or with ametropia ranged ±0.75 D. There was no separation between hyperopic, myopic or emmetropic patients.
Place and Duration of Study: University of West Attica Dept Biomedical Science Course Optics & Optometry in collaboration with Private Ophthalmology Clinic O.M.M.A. during the period between January 2019 to October 2019.
Methodology: In this study, two basic structures of the eye are measured with the help of two devices of different principle of operation. Specifically, the study of the angle of the anterior chamber (ACA) as well as the depth of the chamber (ACD). The two devises are compared.
Results: The ACA for both devices had mean difference of -2,004° for the R.E. while the mean difference for L.E. was 1,986°. Pentacam arithmetic mean ACA (R.E.) was 37,638 ± 2,98° and AS-OCT “Spectralis” 35,766 ± 2,90° with Correlation coefficient 0,7063 (P<0,0001). Pentacam arithmetic mean ACA (L.E.) was 37,638 ± 2,98° and AS-OCT “Spectralis” 35,652 ± 2,79° with Correlation coefficient 0,7569 (P<0,0001). The ACD for both devices had mean difference of -0,3028 for the R.E. while the mean difference for L.E. was -0,2860. Pentacam arithmetic mean ACD (R.E.) was 3,5866 ± 0,20 and AS-OCT “Spectralis” 3,2838 ± 0,20 with Correlation coefficient 0,4201 (P=0,0024). Pentacam arithmetic mean ACD (L.E.) was 3,558 ± 0,21 and AS-OCT “Spectralis” 3,2720 ± 0,20 with Correlation coefficient 0,4023 (P=0,0038).
Conclusion: Values of ACA measured by Pentacam and AS-OCT “Spectralis” were similar within the sample population of normal eyes right and left (P<0,0001). ACD measured by Pentacam and AS-OCT “Spectralis” showed also similar results the sample population of normal eyes for the right eye (P=0,0024) and left (P=0,0038).
Measures against COVID‐19 concerning Summer Indoor Environment in Japan
Authors: Hayashi Motoya , Yanagi U , Azuma Kenichi , Kagi Naoki , Ogata Masayuki , Morimoto Shoichi , Hayama Hirofumi , Mori Taro , Kikuta Koki , Tanabe Shin‐ichi , Kurabuchi Takashi , Yamada Hiromi , Kobayashi Kenichi , Kim Hoon , Kaihara Noriko 
Published: August 2020

AbstractInformation on air‐conditioning and ventilation has been continuously disseminated in response to the Japanese Government's announcement of the need for appropriate ventilation measures against the new coronavirus disease (COVID‐19), and the issuing of an emergency presidential discourse by the presidents of Engineering Societies. In this paper, we add to the information the latest knowledge on the behavior of SARS‐CoV‐2 in air, describe its diffusion characteristics in the built environment, and summarize the effects of temperature and humidity on the virus. Then we recommend varying approaches of air‐conditioning control for facility type.
Fischer–Tropsch synthesis with ethene co‐feeding: Experimental evidence of the CO‐insertion mechanism at low temperature
Authors: Zhang Yusheng , Yao Yali , Chang Jianli , Lu Xiaojun , Liu Xinying , Hildebrandt Diane 
Published: August 2020

AbstractExperiments were performed at both normal and rather extreme Fischer–Tropsch Synthesis (FTS) operating conditions over a typical cobalt‐based catalyst, with the aim of exploring if aspects of the reaction mechanism could be elucidated. The results show that CO reacted when co‐feeding C2H4 with syngas, while CO did not react with H2 in absence of C2H4, under extremely low‐temperature conditions (140°C). The adsorbed CO and C2H4 may behave as monomers and initiators, respectively, and react with each other to form long chain hydrocarbons. It suggests that the CC bond coupling precedes the CO bond dissociation, which is consistent with the CO‐insertion mechanism. C3–6 product distribution with a feed of H2/CO/C2H4 at low temperature followed the same trends in terms of normal FTS product distribution. The observed FTS‐type chain growth reaction that occurs at abnormally low temperatures (140°C) when co‐feeding C2H4 may provide new insights into the chemistry of FTS.
Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease
Authors: Mengel David , Janelidze Shorena , Glynn Robert J. , Liu Wen , Hansson Oskar , Walsh Dominic M. 
Published: August 2020

ObjectiveThere is an urgent need for sensitive, widely available, blood‐based screening tests to identify presymptomatic individuals destined to develop Alzheimer's disease (AD). We investigated whether tau detected in plasma by our in‐house NT1 assay is specifically altered in AD, and when applied to patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) can serve to predict progression to AD dementia. The predictive value of NT1 versus tau measured using assays from Quanterix and Roche, and the specificity of NT1 for AD versus a nonspecific marker of neurodegeneration (neurofilament light [NfL]) were also examined.MethodsNT1 tau and NfL were measured in plasma from prospectively followed patients with SCD or MCI who remained cognitively stable, converted to AD dementia, or converted to non‐AD dementias, and in cognitively unimpaired participants. Tau was measured using Quanterix and Roche assays in baseline subjects with SCD and MCI.ResultsPlasma NT1 tau was specifically elevated in AD, but not in non‐AD dementia compared with controls, whereas NfL was increased in both AD and non‐AD dementias. Baseline specimens from individuals who had SCD or MCI revealed that NT1 tau, but not tau measured using Quanterix or Roche assays, is elevated in subjects who progress to AD dementia. As expected, baseline plasma NfL is elevated in those who progress to AD and non‐AD dementias.InterpretationPlasma NT1 tau is a specific marker of AD, which is elevated early in disease and may prove useful as a first round screen to identify individuals at risk of developing AD. ANN NEUROL 2020;88:878–892