bluuebunny/crossref_metadata_2025_split huggingface dataset:
YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin
Authors: Sun Ting , Mao Wenhao , Jiao Lin , Wan Junhu , Ming Liang 
Published: April 2020

Abstract
Background

Sorafenib is the standard first-line treatment for advanced hepatocellular carcinoma (HCC), but its use is hampered by the secondary drug resistance. Yes-associated protein (YAP) is the crucial downstream effector of the Hippo signaling pathway, which is crucial for liver tumorigenesis. However, the underlying mechanism regarding YAP and sorafenib resistance remains unclear.
Methods

Western blotting, flow cytometry, and CCK-8 assay were used to confirm the role of YAP in HCC sorafenib resistance. RT-PCR and western blotting were then performed to identify survivin as downstream of YAP, whereas rescue experiments were performed to confirm that YAP induces sorafenib resistance via survivin. Further, western blotting, flow cytometry, and an in vivo xenograft model were used to evaluate the function of verteporfin in combination with sorafenib in HCC.
Results

We found that sorafenib enhances YAP nuclear accumulation and activates YAP, which promotes sorafenib resistance by inhibiting apoptosis in HCC cells. Moreover, survivin acted as a downstream mediator of YAP to resist sorafenib-induced apoptosis. Pharmacological inhibition of YAP by verteporfin inhibited HCC cells proliferation and restored the sensitivity to sorafenib. Moreover, verteporfin in combination with sorafenib significantly suppressed HepG2 xenograft tumor growth.
Conclusions

Our study indicates that YAP promotes sorafenib resistance in HCC through upregulating survivin expression. Targeting YAP may be a potential therapeutic strategy to improve the antitumor effects of sorafenib in HCC.
RESPONSABILIDADE CIVIL DECORRENTE DO ABANDONO AFETIVO PARENTAL E SUA CONSEQUÊNCIAS À FILIAÇÃO
Authors: ANJOLETTO Joyce de Paula , BIANCO João Carlos 
Published: April 2020

Este estudo tem como objetivo inserir um debate sobre a eficácia do cabimento ou não da aplicação da responsabilidade civil no abandono afetivo, com ênfase às sérias consequências para com a filiação. A presente pesquisa propõe-se a apresentar os graves malefícios que o abandono afetivo possa vir a refletir na vida de crianças e adolescentes atingidos, trazendo concomitantemente, os respectivos aspectos favoráveis e contrários à introdução do instituto da responsabilidade civil como reparador dessas mazelas. Assim, por meio da exposição de estudos realizados a respeito do tema, mostra-se evidente a importância do afeto dentro do núcleo familiar, pois a sua ausência representa um desrespeito aos princípios e garantias constitucionais, porque apesar de inexistir legislação acerca do abandono afetivo, a proteção à integridade de crianças e adolescentes encontra-se amparada pela Constituição Federal e o Estatuto da Criança e do Adolescente responsáveis por assegurar direitos fundamentais que garantem seu desenvolvimento.
Review of Volodymyr Yavorivsky. The Chornobyl Madonna & Valeriy Shevchuk. Breath of Evil: Novellas Written by the Goatherd Ivan Shevchuk and Fashioned for Literary Use by His Great-Grandnephew.
Authors: Pavlyshyn Marko 
Published: April 2020

Review of:
Volodymyr Yavorivsky. The Chornobyl Madonna. Translated from the Ukrainian by Yuri Tkacz, Bayda Books, 2016. 192 pp. Paper.
Valeriy Shevchuk. Breath of Evil: Novellas Written by the Goatherd Ivan Shevchuk and Fashioned for Literary Use by His Great-Grandnephew. Translated from the Ukrainian by Yuri Tkacz, foreword by Marko R. Stech, Bayda Books, 2016. 246 pp. Paper.
The Therapeutic Potential and Usage Patterns of Cannabinoids in People with Spinal Cord Injuries: A Systematic Review
Authors: Nabata Kylie J. , Tse Emmanuel K. , Nightingale Tom E. , Lee Amanda H.X. , Eng Janice J. , Querée Matthew , Walter Matthias , Krassioukov Andrei V. 
Published: April 2020

Background:
People with spinal cord injuries (SCI) commonly experience pain and spasticity;
limitations of current treatments have generated interest in cannabis as a possible therapy.

Objectives:
We conducted this systematic review to: 1) examine usage patterns and reasons for cannabinoid
use, and 2) determine the treatment efficacy and safety of cannabinoid use in people with
SCI.

Methods:
PubMed, Embase, Web of Science and Cumulative Index to Nursing and Allied Health
Literature databases were queried for keywords related to SCI and cannabinoids.

Results:
7,232 studies were screened, and 34 were included in this systematic review. Though 26
studies addressed cannabinoid usage, only 8 investigated its therapeutic potential on outcomes such
as pain and spasticity. The most common method of use was smoking. Relief of pain, spasticity and
recreation were the most common reasons for use. A statistically significant reduction of pain and
spasticity was observed with cannabinoid use in 83% and 100% of experimental studies, respectively.
However, on examination of randomized control trials (RCTs) alone, effect sizes ranged from -
0.82 to 0.83 for pain and -0.95 to 0.09 for spasticity. Cannabinoid use was associated with fatigue
and cognitive deficits.

Conclusion:
Current evidence suggests that cannabinoids may reduce pain and spasticity in people
with SCI, but its effect magnitude and clinical significance are unclear. Existing information is lacking
on optimal dosage, method of use, composition and concentration of compounds. Long-term,
double-blind, RCTs, assessing a wider range of outcomes should be conducted to further understand
the effects of cannabinoid use in people with SCI.
Online Romance Scams: Relational Dynamics and Psychological Characteristics of the Victims and Scammers. A Scoping Review
Authors: Coluccia Anna , Pozza Andrea , Ferretti Fabio , Carabellese Fulvio , Masti Alessandra , Gualtieri Giacomo 
Published: April 2020

Background:
Digital communication technologies can overcome physical, social and psychological barriers in building romantic relationships. Online romance scams are a modern form of fraud that has spread in Western societies along with the development of social media and dating apps. Through a fictitious Internet profile, the scammer develops a romantic relationship with the victim for 6-8 months, building a deep emotional bond to extort economic resources in a manipulative dynamic. There are two notable features: on the one hand, the double trauma of losing money and a relationship, on the other, the victim's shame upon discovery of the scam, an aspect that might lead to underestimation of the number of cases.

Objectives:
This paper presents a scoping review of the quantitative and qualitative evidence on this issue, focusing on epidemiological aspects, relational dynamics, and the psychological characteristics of victims and scammers.

Methods:
A literature scoping review was conducted using electronic databases and descriptors. Studies were included if they had analyzed the phenomenon in any population or the relationship dynamics characterizing it through whatsoever typology of design. Scoping reviews are a form of knowledge synthesis, which incorporates a range of study designs and wide eligibility criteria to comprehensively summarize evidence with the aim of informing practice, programs, and policy and providing direction to future research priorities.

Results:
Twelve studies were included. Sixty-three percent of social media users and 3% of the general population report having been a victim at least once. Some psychological variables appear to be associated with the risk of being scammed, such as female gender, middle-age, higher levels of neuroticism, tendencies to the romantic idealization of affective relations, sensation seeking, impulsiveness and susceptibility to addiction. We analyse literature limitations and future directions.

Conclusion:
Since this emerging phenomenon is still largely unrecognized, understanding the psychological characteristics of victims and scammers will allow at-risk personality profiles to be identified and prevention/intervention strategies to be developed.
Mobile Applications for the Promotion and Support of Healthy Nutrition and Physical Activity Habits: A Systematic Review, Extraction of Features and Taxonomy Proposal
Authors: Villasana María Vanessa , Pires Ivan Miguel , Sá Juliana , Garcia Nuno M. , Zdravevski Eftim , Chorbev Ivan , Lameski Petre , Flórez-Revuelta Francisco 
Published: April 2020

Background:Mobile applications can be used for the monitoring of lifestyles and physical activity. It can be installed in commodity mobile devices, which are currently used by different types of people in their daily activities worlwide .Objective:This paper reviews and categorizes the mobile applications related to diet, nutrition, health, physical activity and education, showing the analysis of 73 mobile applications available on Google Play Store with the extraction of the different features.Methods:The mobile applications were analyzed in relation to each proposed category and their features, starting with the definition of the search keywords used in the Google Play Store. Each mobile application was installed on a smartphone, and validated whether it was researched in scientific studies. Finally, all mobile applications and features were categorized.Results:These mobile applications were clustered into four groups, including diet and nutrition, health, physical activity and education. The features of mobile applications were also categorized into six groups, including diet, anthropometric parameters, social, physical activity, medical parameters and vital parameters. The most available features of the mobile applications are weight, height, age, gender, goals, calories needed calculation, diet diary, food database with calories, calories burned and calorie intake.Conclusion:With this review, it was concluded that most mobile applications available in the market are related to diet, and they are important for different types of people. A promising idea for future work is to evaluate the acceptance by young people of such mobile applications.
In Vitro Cytotoxicity Evaluation of Oxytetracycline Loaded Cockle Shell Derived Calcium Carbonate Aragonite Nanoparticles
Authors: Idris Sherifat B. , Arifah Abdul K. , Jesse Faez F.A. , Ramanoon Siti Z. , Basit Muhammad A. , Zakaria Mohammad Z.A.B. 
Published: April 2020

Background:
Evaluation of the toxic effects of nanoparticle-drug in vitro is an important
step in the design of new pharmaceutical formulations. Rapid results, reduced cost and easy handling
make cell culture models first line in initial toxicological assessment of nano-drug preparations.

Objective:
To evaluate the in vitro cytotoxicity of oxytetracycline loaded calcium carbonate aragonite
nanoparticle in normal mouse fibroblast (NIH3T3) cell line.

Methods:
NIH3T3 cells were exposed to varying concentrations (6.25-100 μg/mL) of calcium carbonate
aragonite nanoparticle (CS-CaCO3NP), oxytetracycline loaded calcium carbonate aragonite
nanoparticle (OTC-CS-CaCO3NP) and oxytetracycline (OTC) in 96 well plates for 24, 48 and 72
hours. Cell viability was determined by MTT and trypan blue assays.

Result:
Both assays showed that CS-CaCO3NP and OTC-CS-CaCO3NP had higher cell viability
values compared to OTC.

Conclusion:
Encapsulating OTC into CS-CaCO3NP reduced its cytotoxicity to NIH3T3 cells using
both MTT and trypan blue assay.
Associations of Electronic Device Use Before and After Sleep With Psychological Distress Among Chinese Adults in Hong Kong: Cross-Sectional Study
Authors: Lee Jung Jae , Wang Man Ping , Luk Tzu Tsun , Guo Ningyuan , Chan Sophia Siu-Chee , Lam Tai Hing 
Published: April 2020

Background
Hong Kong has a high rate of electronic device (e-device; computer, smartphone, and tablet) use. However, little is known about the associations of the duration of e-device use before and after sleep with psychological symptoms.

Objective
This study aimed to investigate the associations of the duration of e-device use before and after sleep with psychological distress.

Methods
A probability-based telephone survey was conducted on 3162 Hong Kong adults (54.6% female; mean age 47.4 years, SD 18.3 years) in 2016. Multivariate linear and Poisson regressions were used to calculate adjusted regression coefficients (aBs) and prevalence ratios (aPRs) of anxiety and depressive symptoms (measured by Patient Health Questionnaire-4) for the duration from waking to the first e-device use (≥61, 31-60, 6-30, and ≤5 minutes) and the duration of e-device use before sleeping (≤5, 6-30, 31-60, and ≥61 minutes).

Results
The first e-device use in ≤5 (vs ≥61) minutes after waking was associated with anxiety (aB 0.35, 95% CI 0.24-0.46; aPR 1.74, 95% CI 1.34-2.25) and depressive symptoms (aB 0.27, 95% CI 0.18-0.37; aPR 1.84, 95% CI 1.33-2.54). Using e-devices for ≥61 (vs ≤5) minutes before sleeping was also associated with anxiety (aB 0.17, 95% CI 0.04-0.31; aPR 1.32, 95% CI 1.01-1.73) and depressive symptoms (aB 0.17, 95% CI 0.05-0.28; aPR 1.47, 95% CI 1.07-2.02). E-device use both ≤5 minutes after waking and for ≥61 minutes before sleeping was strongly associated with anxiety (aB 0.68, 95% CI 0.47-0.90; aPR 2.64, 95% CI 1.90-3.67) and depressive symptoms (aB 0.55, 95% CI 0.36-0.74; aPR 2.56, 95% CI 1.69-3.88).

Conclusions
E-device use immediately (≤5 minutes) after waking and use for a long duration (≥61 minutes) before sleeping were associated with anxiety and depressive symptoms among Chinese adults in Hong Kong.
Menstrual Cycle Length and Patterns in a Global Cohort of Women Using a Mobile Phone App: Retrospective Cohort Study
Authors: Grieger Jessica A , Norman Robert J 
Published: April 2020

Background
There is increasing information characterizing menstrual cycle length in women, but less information is available on the potential differences across lifestyle variables.

Objective
This study aimed to describe differences in menstrual cycle length, variability, and menstrual phase across women of different ages and BMI among a global cohort of Flo app users. We have also reported on demographic and lifestyle characteristics across median cycle lengths.

Methods
The analysis was run based on the aggregated anonymized dataset from a menstrual cycle tracker and ovulation calendar that covers all phases of the reproductive cycle. Self-reported information is documented, including demographics, menstrual flow and cycle length, ovulation information, and reproductive health and diseases. Data from women aged ≥18 years and who had logged at least three cycles (ie, 2 completed cycles and 1 current cycle) in the Flo app were included (1,579,819 women).

Results
Of the 1.5 million users, approximately half (638,683/1,579,819, 40.42%) were aged between 18 and 24 years. Just over half of those reporting BMIs were in the normal range (18.5-24.9 kg/m2; 202,420/356,598, 56.76%) and one-third were overweight or obese (>25 kg/m2; 120,983/356,598, 33.93%). A total of 16.32% (257,889/1,579,819) of women had a 28-day median cycle length. There was a higher percentage of women aged ≥40 years who had a 27-day median cycle length than those aged between 18 and 24 years (22,294/120,612, 18.48% vs 60,870/637,601, 9.55%), but a lower percentage with a 29-day median cycle length (10,572/120,612, 8.77% vs 79,626/637,601, 12.49%). There were a higher number of cycles with short luteal phases in younger women, whereas women aged ≥40 years had a higher number of cycles with longer luteal phases. Median menstrual cycle length and the length of the follicular and luteal phases were not remarkably different with increasing BMI, except for the heaviest women at a BMI of ≥50 kg/m2.

Conclusions
On a global scale, we have provided extensive evidence on the characteristics of women and their menstrual cycle length and patterns across different age and BMI groups. This information is necessary to support updates of current clinical guidelines around menstrual cycle length and patterns for clinical use in fertility programs.
The Impact of Video-Mediated Communication on Closed Wound Assessments in Postoperative Consultations: Conversation Analytical Study
Authors: Stommel Wyke J P , van Goor Harry , Stommel Martijn W J 
Published: April 2020

Background
Research on the use of video-mediated technology for medical consultations is increasing rapidly. Most research in this area is based on questionnaires and focuses on long-term conditions. The few studies that have focused on physical examinations in video consultations indicated that it poses challenges for the participants. The specific activity of wound assessment through video in postsurgery consultations has not yet been studied. Furthermore, a comparative analysis of face-to-face and video settings on the moment-to-moment organization of such an activity is original.

Objective
The aim of this study was to examine the impact of video technology on the procedure of postsurgery wound assessment and its limits.

Methods
We recorded 22 postoperative video consultations and 17 postoperative face-to-face consultations. The primary purpose of the consultation was to inform the patient about the final pathology results of the resected specimen, and the secondary purpose was to check on the patient’s recovery, including an assessment of the closed wound. The recordings were transcribed in detail and analyzed using methods of conversation analysis.

Results
The way that an assessment of the wound is established in video consultations differs from the procedure in face-to-face consultations. In the consultation room, wound assessments overwhelmingly (n=15/17) involve wound showings in the context of surgeons reporting their observations formatted with evidentials (“looks neat”) and subsequently assessing what these observations imply or what could be concluded from them. In contrast, wound assessments in video consultations do not tend to involve showing the wound (n=3/22) and, given the technological restrictions, do not involve palpation. Rather, the surgeon invites the patient to assess the wound, which opens up a sequence of patient and physician assessments where diagnostic criteria such as redness or swollenness are made explicit. In contrast to observations in regular consultations, these assessments are characterized by epistemic markers of uncertainty (“I think,” “sounds...good”) and evidentials are absent. Even in cases of a potential wound problem, the surgeon may rely on questioning the patient rather than requesting a showing.

Conclusions
The impact of video technology on postoperative consultations is that a conclusive wound assessment is arrived at in a different way when compared to face-to-face consultations. In video consultations, physicians enquire and patients provide their own observations, which serve as the basis for the assessment. This means that, in video consultations, patients have a fundamentally different role. These talking-based assessments are effective unless, in cases of a potential problem, patient answers seem insufficient and a showing might be beneficial.
Study on performance of progressing cavity pumps (PCPs) in different fit modes
Authors: ZHENG Lei , WU Xiaodong , ZHAO Ruidong , LI Huachang , LIU Mengyun 
Published: April 2020

The performance of progressing cavity pumps（PCPs）is significantly different in different fit modes between the stators and rotors，such as interference fit for conventional PCPs with rubber stators and clearance fit for novel all metal PCPs. In order to study the influence of fit modes on PCP performance, a novel concept of fit parameter is introduced to quantitatively describe the fit condition. Based on working principles of PCPs, comprehensive studies are carried out on pump performance in different fit modes, including volumetric characteristics, power consumption and work efficiency. The results show that the theoretical pump rate slightly decreases with the increase of the fit parameter. Though there is obvious friction inside the pump and the interference has a great impact on power consumption, the PCP in interference fit is able to achieve high volumetric efficiency (&gt;80%). Though there is inevitable leakage and the clearance has a significant influence on flow rate, the PCP in clearance fit can reach high mechanical efficiency (&gt;90%). The novel all metal PCP in clearance fit has enormous potential for development owing to its good overall performance.
Utilization of Marble and Boron Waste in Brick Products
Authors: EVCİN Atilla , ERSOY Bahri , ÇİFTÇİ Hakan 
Published: April 2020

In
this study, usability of marble and boron wastes as alternative raw materials
in the production of bricks was investigated. They were used in different
ratios to prepare samples. Marble waste
in concentrations of 5, 10, 15 and 20 wt% were added to the boron waste. Afyon
brick clay was used as a binder in 10 wt%. Specimens were shaped by hydraulic
press and fired at temperatures from 850 to 1050 °C for 4 hours. The crystalline structure and
morphologies of the samples are characterized by X-ray powder diffractometer
(XRD) and scanning electron microscopy (SEM), respectively. Flexural strengths
of samples were measured. The reasonable mechanical properties have been
obtained from the brick sample containing 5 wt% marble waste, 85 wt% boron
waste and 10 wt% clay sintered at 1050 °C for 4 hours.
Оценка Индекса Инклюзивного Развития на Основе Нейросетевой Модели REL-PCANet
Authors: Ирматов Анвар Адхамович , Ирматова Эльнура Анваровна 
Published: April 2020

В 2018 году на Всемирном экономическом форуме в Давосе была представлена новая метрика экономической эффективности стран под названием Индекс инклюзивного развития (IDI), состоящий из 12 показателей. Новая метрика подразумевает, что странам может потребоваться проведение структурных реформ для улучшения как экономического роста, так и эффективности социальной инклюзивности. Именно поэтому важно, чтобы метод расчета IDI имел сильную статистическую и математическую основу для точности и прозрачности результатов и их дальнейшего использования в общественных целях.В данной работе мы предлагаем новый подход к оценке IDI — нейросетевую модель REL-PCANet, которая основана на принципах RELARM и RankNet и объединяет элементы PCA, методы, применяемые в распознавании изображений и механизмах обучения ранжированию. Кроме того, мы определяем новый подход к оценке матрицы целевых вероятностей TRnet для отражения динамических изменений в инклюзивном развитии стран. Эмпирическое исследование показало, что REL-PCANet обеспечивает надежные оценки и результаты ранжирования, что позволяет рекомендовать ее для использования в практической деятельности.