bluuebunny/crossref_metadata_2025_split huggingface dataset:
Device‐Measured Physical Activity, Sedentary Behaviour and Risk of Chronic Kidney Diseases Across Levels of Grip Strength
Authors: He Yu , Wang Jing , Zhang Weijie , Chen Xinru , Wu Qiqi , Li Yuxuan , Ou Yiliang , Liu Yaping , Feng Hongliang , Zhang Jihui , Ai Sizhi , Liang Yannis Yan , Ning Yuping , Zhang Jun 
Published: February 2025

ABSTRACTBackgroundThe study aimed to investigate whether the associations of accelerometer‐measured physical activity (PA) and sedentary behaviour (SB) with incident chronic kidney disease (CKD) vary based on different levels of hand grip strength, identifying the modifying role of grip strength in these associations.MethodsThe study included 87 487 adults from the UK Biobank. PA and SB were quantified using accelerometers over 7‐day period, while grip strength was assessed using a hand dynamometer. CKD events were ascertained through hospital records or death registries.ResultsParticipants had a mean age of 62.3 years, with 57.2% (50 062) identifying as female and 97% as White. Over a median follow‐up of 7.0 years, the total incidence rate of CKD was 4.7 per 1000 person‐years. Participants who performed higher volumes of PA were more likely to be younger; have better control of body weight, blood glucose and blood pressure; and have fewer major comorbidities (p < 0.001). Total PA, moderate‐to‐vigorous intensity PA (MVPA), and light intensity PA (LPA), were inversely associated with CKD risk in a dose–response manner (all poverall < 0.050). In contrast, SB was associated with a higher risk of CKD (poverall < 0.001). Hand grip strength significantly modified the relationship between PA, SB, and CKD risk (pinteraction < 0.10). The associations of total PA (HR, 0.70; 95% CI, 0.59–0.84), MVPA (HR, 0.75; 95% CI, 0.65–0.88), LPA (HR, 0.81; 95% CI, 0.69–0.94), and SB (HR, 1.43; 95% CI, 1.21–1.69) with CKD risk were more remarkable among individuals with lower hand grip strength. Of note, physical inactivity ranked higher in relative strength for predicting CKD than hypertension, diabetes, and obesity.ConclusionsHand grip strength could significantly modify the associations of accelerometer‐measured PA and SB with the risk of CKD. Regardless of intensity, PA consistently correlates with reduced risk of CKD, while SB is associated with increased risk, especially among individuals with lower grip strength. Notably, physical inactivity was found to be as predictive of CKD as traditional risk factors, highlighting the importance of promoting PA, especially among those with lower grip strength.
Impacts of the Pacific Decadal Oscillation and El Nino‐Southern Oscillation on Regional Precipitation Concentration
Authors: Kang Yinhong , Ni Tiefeng , He Shuai , Cao Zihua , Wu Guixiong , Tong Jianghao , Ye Zhaokai 
Published: February 2025

ABSTRACTExploring the regional precipitation concentration index (PCI) provides profound insights into the distribution patterns of rainfall within a specific area. This study utilised daily precipitation data from Sichuan Province to investigate the spatiotemporal variations of PCI on annual and seasonal scales, as well as its potential relationships with the Pacific Decadal Oscillation (PDO) and El Niño‐Southern Oscillation (ENSO). A modified Mann‐Kendall test was employed to identify significant trends in the PCI. Furthermore, this study examined the relationships between the daily concentration index (CID) and the monthly concentration index (CIM), along with their spatiotemporal characteristics. The remote potential relationships between PCI and ENSO/PDO were analysed using cross wavelet transform and correlation test. The results indicate that: (1) A significant positive correlation exists between CID and CIM in the central Sichuan basin (CB) region, while this correlation is not significant in other regions. (2) There is a non‐significant decreasing trend in precipitation concentration across Sichuan Province, primarily observed in spring. (3) The spatial and temporal distribution of PCI in Sichuan Province becomes increasingly variable and irregular with decreasing longitude and increasing elevation. (4) The negative impact of ENSO and PDO on annual PCI and autumn PCI significantly diminish from east to west. In summer, the potential negative impact of PDO on Seasonal precipitation concentration index (SPCI) significantly decreases from north to south. This study provides key information to reveal the variations and potential influences of meteorological and hydrological processes in Sichuan Province.
Oropharyngeal Cancer and the HPV Vaccine: Analysis of Social Media Content
Authors: Matthews Makayla R. , Abdulbaki Hasan , Ryan William R. , Hackman Trevor G. , Farzal Zainab 
Published: February 2025

ABSTRACTObjectiveHuman Papillomavirus (HPV) is a well‐documented cause of cervical, oropharyngeal, vaginal, vulvar, anal, and penile cancers, largely preventable with the HPV vaccine. We aim to characterize the most popular TikTok videos pertaining to HPV‐associated cancers and vaccination with a focus on oropharyngeal cancer.MethodsObservational study of public social media content. The top 200 TikTok videos that appeared when searching for #HPVvaccine and #Gardasil individually were included and analyzed on the basis of creator characteristics, viewer reach, content, and accessibility. Characteristics of each video were counted if mentioned or listed in the caption.ResultsForty‐four percent of videos originated from creators self‐identifying as health care professionals and had an average of 129,525 (SD: 59,997) views. 72.0% were pro‐vaccination, and 17.5% were specifically anti‐vaccination. Only 14.0% mentioned all six types of HPV‐related cancer (including oropharyngeal). Other mentions included HPV prevention (62.0%), transmission (31.0%), infection risk factors (12.0%), and vaccine side effects (23.0%), while only 7.5% specifically regarded vaccines as safe. 35.5% of creators identified the Gardasil vaccine as appropriate for both men and women.ConclusionsMedical professionals have a strong presence on TikTok and overwhelmingly support HPV vaccination for cancer prevention but miss the mark in associating high‐risk HPV with non‐cervical cancers, addressing vaccine safety, and clearly defining who is eligible for the HPV vaccine/Gardasil. Despite oropharyngeal cancer eclipsing cervical cancer as the most common HPV‐related malignancy, there is still a dearth of online patient education about this disease and the potential treatment/prevention measures available.
Long‐Term Efficacy and Safety of a Novel Monopolar Radiofrequency Device for Skin Tightening: A Prospective Randomized Controlled Study
Authors: Wang Zhongshuai , Li Li , Zhang Xiaofeng , Li Zhenzhen , Yan Yan 
Published: February 2025

ABSTRACTObjectivesTo evaluate the efficacy and safety of a novel monopolar RF device for skin tightening and rejuvenation treatment.MethodsForty participants were enrolled in the study. Subjects randomized to the treatment group received a single treatment with the novel RF device (YOUMAGIC), whereas the control group received regular RF treatment (Thermage CPT; Solta Medical). Digital photographs and Antera 3D photographs were taken at baseline, 1‐, 3‐, and 6‐month posttreatment. The depression volume of nasolabial folds (NLFs) in each visit was evaluated using the Antera 3D imaging program. The pain was evaluated by pain measurement scales immediately after treatment. Any procedure‐related side effects were documented and examined.ResultsPosttreatment results were compared with the baseline; statistically significant mean depression volume (MDV) changes of NLFs were found at 1, 3, and 6 months posttreatment. No significant MDV changes were found between the treatment and control groups. No severe adverse events were reported.ConclusionsOur study demonstrates that the novel monopolar RF device is clinically safe and effective for skin tightening in the lower face area, and is not inferior to the regular RF therapeutic device.
Quercetin‐Based Magnetic Porous Organic Polymers for Efficient Adsorption of Phenolic Pollutants
Authors: Zhu Qimeng , Nie Zewen , Yang Dongxin , Sun Lijun , Wang Liqiu , Gong Weitao 
Published: February 2025

AbstractPhenolic wastewater poses a significant threat to public health, highlighting the urgent need for the development of effective and efficient treatment methods. Porous organic polymers, renowned for their high structural stability, large surface area, and diverse physicochemical properties, have gained widespread application in adsorption‐based technologies. Therefore, the development of novel adsorbent materials remains a crucial area of scientific research. In this study, a novel porous organic polymer adsorbent is synthesized using quercetin, derived from biomass, as the key precursor. To facilitate efficient separation and reusability, magnetic Fe3O4@SiO₂ magnetic nano‐particle nanoparticles (MNPs) are integrated into the porous matrix. The resulting magnetic organic porous adsorbents exhibited outstanding adsorption capacity for phenolic contaminants, along with excellent recoverability and reusability. Additionally, the adsorption mechanism is systematically investigated and verified through a series of characterization techniques.
An Injectable PEG/Diacerein‐Based Anti‐Inflammatory Hydrogel for Promoting Cartilage Regeneration: An In Vivo Study
Authors: Mi Jing , Meng Linghui , Wang Yutian , Zhang Huanyu , Jin Jing , Huang Jianhao , Lu Jingwei , Ying Pu , Li Lan 
Published: February 2025

AbstractCartilage defects are common joint disorders that, if left untreated, may progress to severe degenerative joint conditions. Inflammatory response plays a critical role in the pathogenesis of cartilage damage. Hydrogels incorporating diacerein, an anti‐inflammatory drug used in clinical settings, can mitigate inflammation that impairs cartilage repair. It is hypothesized that the direct injection of a hydrogel scaffold combining diacerein and polydopamine into cartilage defect sites can enhance localized treatment, reduce surgical risks, and expedite recovery. Therefore, in this study, a hydrogel infused with diacerein is developed to investigate its efficacy for cartilage restoration. By crosslinking poly(ethylene glycol) diacrylate, four‐arm polyethylene glycol‐functionalized diacerein, hyaluronic acid, and polydopamine, an injectable hydrogel with superior properties is achieved. In vitro evaluations confirm the mechanical strength and biocompatibility of the hydrogel, and in vivo studies demonstrate its effectiveness in cartilage repair and anti‐inflammatory activity in a rat model. These findings indicate that hydrogels are promising materials for addressing cartilage defects and advancing tissue engineering and biological implantation strategies.
Linseed Oil Microencapsulation for Advanced Corrosion Protection Coatings: A Review
Authors: Che Zakaria Farasuraya , Kabeb Siti Maznah Binti , Bakar Nurul Huda Abu , Rahman Atif Ur 
Published: February 2025

AbstractCorrosion poses a persistent challenge in various industries, necessitating effective protective measures for metal structures. This review not only delves into the overall realm of microencapsulation in corrosion protection but also contributes a unique perspective by extensively examining recent advancements in the microencapsulation of linseed oil. Emphasizing a novel approach, the review introduces advancements in self‐healing features, diverse microencapsulation techniques, environmentally friendly shell materials, and the critical role of capsule size and distribution. The study addresses a noticeable gap in the existing literature, aiming to contribute unique insights and solutions to the challenges faced in the field of corrosion protection.
Comparative Study of Manganese and Cobalt Oxide Doped Zinc Oxide as Photocatalyst Nanomaterials
Authors: Sures Nisallini , Aridi Mohd Radzi , Aziz Nur Aimi Syaqilah , Thivagaran Rihashni , Norapandi Nurul Fatihah , Salim Nurjannah , Abu Bakar Nurul Huda 
Published: February 2025

AbstractThe research extensively explores the optical, structural, and morphological characteristics of zinc oxide (ZnO) doped with manganese and cobalt nanoparticles, with a specific focus on their impact on photocatalytic activity. ZnO, known for its cost‐effectiveness and high efficiency due to a broadband gap (≈3.37 eV), is widely studied as a semiconductor photocatalyst. However, ZnO's intrinsic limitation lies in its predominant photocatalytic activity under UV light irradiation. To address this, transition metal ions (Mn and Co) are introduced to the ZnO lattice to create new energy levels in the band gap. By optimizing the dosage of the Mn‐ZnO and Co‐ZnO photocatalyst, the work presents a noteworthy impact, contributing to a significant reduction in photodegradation time (≈30 min), demonstrating the enhanced efficiency of the photocatalytic process.
Efficient Methylene Blue Dye Degradation Using ZnO Nanoparticles Synthesized Using Abroma augusta Leaf Extract
Authors: Gupta Komal , Sharma Basudha , Garg Vijay , Ahmad Ikrar 
Published: February 2025

AbstractZinc oxide nanoparticles (ZnO NPs) are among the most advanced materials due to their ability to apply in versatile applications and have been formulated by several approaches, including green chemistry methods. Plant based green synthesis of ZnO NPs have gained tremendous attention because of their safe and non‐toxic nature. In this study, ZnO NPs have been produced using the leaf extract of Abroma augusta (also known as Ulatkambal) and have been utilized for photocatalytic degradation of Methylene blue Dye. The characterization of these NPs have been carried out using XRD, XPS, FESEM, and FTIR which shows the formation of ZnO NPs in the hexagonal wurtzite structure with the crystallite size of ≈11 nm. The FESEM images show the formation of nanoparticles in the size distribution of 2–22 nm and with the average particle of 12 nm. The optical study has been carried out using spectrophotometer and spectrofluorometer. The absorbance spectrum shows the peak at 354 nm and the band gap is calculated to be 3.5 eV. These NPs on excitation with 340 nm wavelength show two emission peaks at 374 and 442 nm. The synthesized AbA‐ZnO NPs show increased photocatalytic degradation efficiency for Methylene blue Dye (91%) as compared to ZnO synthsized in the absence of A. augusta leaf extract (42%). The present study attempts to show a novel greener protocol to improve the photodegradation process for different environmental pollutants.
Environmentally Friendly Processes for the Production of Silver Nanoparticles
Authors: Jain Nidhi , Dani Kartik , Chaskar Sahil , Noor I. M. , Yahya M. Z. A. , Koul Aditya , Khatkepatil Revannath 
Published: February 2025

AbstractThe development of sustainable and robust methods for producing nanoparticles is a major turning point in the field of nanotechnology. Silver nanoparticles are important because of their features, which include improving the physical, chemical, and structural qualities vis‐a‐vis their bulk equivalent and the ensuing applications. The various applications of silver nanoparticles (Ag NPs) and their green manufacturing methods are covered in this review, bearing in mind the aforementioned points. This study also emphasized that how important it is to optimize synthesis factors like temperature, pH, and concentration in order to obtain the appropriate attributes for nanoparticles. Then, the possible uses of silver nanoparticles produced through green synthesis are explored. These uses included antimicrobial coatings, medication delivery systems, and environmental cleanup. It establishes the foundation for upcoming studies and advancements in the area of green nanotechnology, fostering a more sustainable future.
Nanoscale NMOS Device Model Analysis and its Characteristics
Authors: Singh Palvinder , Sachdeva Amit , Singh Shruti , Yahya M. Z. A. , Rahman Nor Mas Mira Abd , Pal Rishi 
Published: February 2025

AbstractA 90 nm NMOS MOSFET model is simulated using Silvaco Visual T‐CAD simulator. The materials used to simulate NMOS MOSFET are Al, Si, NpolySi, and SiO2. To overcome the problem of short circuits, lightly‐doped drain (LDD) implantation is applied in NMOS model. The analysis of the model is determined with T‐CAD simulator and obtained threshold voltage (Vth) 2.568 V, while keeping oxide thickness (Tox) 2.373 nm and gate length 0.09 µm. The obtained result is compared with standard ITRS road map and gets almost similar results.
Studying the Effect of AgNPs Derived from Ag‐Complex on Peroxidase Enzymes in Patients with Type2 Diabetes Caused by White Rabbits
Authors: Omar Hala Wathik , Ismail Yaseen Asra'a , Mohammed Mudher Y. 
Published: February 2025

AbstractThe state of oxidative stress concomitant with type 2 diabetes mellitus (DM) is recognized as a significant factor leading to impaired glycemic control. This study is designed to elucidate the clinical benefits of employing silver and palladium nanocompounds in addressing oxidative disturbances. The investigation encompasses twenty rabbits aged between 6 to 12 months, divided into four groups, each comprising five rabbits. The first group comprises healthy rabbits, serving as the control group. The second group consists of induced diabetic rabbits left untreated, also serving as a control group. The third and fourth groups encompass induced diabetic rabbits treated with silver nanocompounds at concentrations of 10 000 micrograms/mL and 20 000 µg mL−1, respectively, relative to body weight. A singular daily dose is administered for a duration of two weeks. The study's findings demonstrated the effects of silver nanocompounds in mitigating oxidative disturbances by reducing blood glucose levels and lowering anti‐thyroid peroxidase antibodies (anti‐TPO), glutathione peroxidase (GSH‐Px), and catalase (CAT) levels. These effects are dose‐dependent and significantly associated with an observable enhancement in glycemic control.
The Effect of the Resistin, Interleukin‐6 Macromolecules, and Tumor Necrosis Factor on Heart Disease
Authors: Hammad Muna Jumaah , Hussein Wasan Nazhan 
Published: February 2025

AbstractThis study includes measuring the concentrations of the variable's hormone ricistin, interleukin‐6 macromolecules, and tumor necrosis factor. A biochemical study is conducted on 100 blood serum samples, 70 samples of them for patients with cardiovascular diseases aged 25–70 years and 30 samples are collected for healthy people as a control group aged 25–70 years. Using enzyme linked immuno sorbent asaay (ELISA). A number of biochemical variables are measured in the blood serum of the groups in this study. Furthermore, the result of the study shows a high significant increase in the concentration of the hormone ricistin, interleukin‐6, and TNF at a probability level (0.01 ≥ p). These results in the blood of patients with cardiovascular diseases compared with the control group of healthy people.
Extraction Design of Flavonoids From Rosemary Plants for the Treatment of Acute Myocardial Infarction in Rats
Authors: Harem Suzan Jumaa , Hashim Shaker Asmaa 
Published: February 2025

AbstractThis research entails a comprehensive assessment involving the measurement of prolyl glycosidase levels and calcium concentrations within a cohort of rats, which are subjected to induce myocardial infarction through subperitoneal injection of physiological solutions following an 18‐h fasting period. The experimental rats are meticulously partitioned into five distinct groups to facilitate comparative analysis. The initial group serves as the healthy control, providing a baseline reference, while the fifth group is administered the pharmaceutical agent simvastatin. The intermediary groups are administered varying concentrations of flavonoids, specifically extracted from the rosemary plant utilizing advanced high‐performance liquid chromatography (HPLC) technology. This study's design is carefully constructed to discern the impact of these interventions on prolyl glycosidase levels and calcium concentrations in the context of induced myocardial infarction. The administered substances, particularly simvastatin and the varied concentrations of rosemary‐derived flavonoids, are strategically chosen to elucidate their potential influences on the measured biochemical parameters. The utilization of advanced HPLC technology for the extraction of flavonoids from rosemary ensures precise and controlled administration of these compounds to the experimental groups. This research design allows for a nuanced exploration of the effects of simvastatin and rosemary‐derived flavonoids on prolyl glycosidase levels and calcium concentrations in the context of induced myocardial infarction. The delineation of the impact of these interventions on the measured biochemical markers contributes to a deeper understanding of potential therapeutic implications, paving the way for further investigations and potentially innovative interventions in cardiovascular health.
Eco‐Friendly Synthesis and Characterization of Iron Oxide (α‐Fe2O3) Nanoparticles Using Macromolecules from Pomegranate Peel Extract
Authors: Hasoon Rabah N. , Abd Ahmed Najem , Majeed Abdulwahhab H. 
Published: February 2025

AbstractDue to environmentally benign process and a large research area, the green synthesis of metal oxide nanoparticles using plant extracts is a possible replacement for conventional physicochemical synthesis methods. In the present investigation, ferric nitrate (Fe(NO3)3.9H2O) and pomegranate peel extract are used to prepare iron oxide nanoparticles (α‐Fe2O3 NPs). These prepared particles are then examined using FTIR spectroscopy, energy‐dispersive X‐ray (EDX), and scanning electron microscopy (SEM). The results of FTIR reveal distinct peaks in the (450–550 cm−1) range, which are ascribed to the vibration of Fe–O in Fe2O3. Prior to this, SEM data demonstrated the shape of iron oxide particles, which has dimensions between 22 and 43 nm and are round and irregular in size.
Molecular Docking Studies of Novel Benzimidazole Macromolecules
Authors: Alheety Nuaman F. , Aldahham Bilal J. M. , Raouafi Noureddine , Mohammed Ahmed M. , Alheety Mustafa A. , Besbes Rafaâ 
Published: February 2025

AbstractBiologically active benzimidazole derivatives are successfully prepared. The produced compound 2‐hydrazinobenzimidazole (N1) and 5‐methoxy‐2‐hydrazinobenzimidazole (N2) have been synthesized via reacting aqueous hydrazine with 2‐mercaptobenzimidazole (MBI) and 5‐methoxy‐2‐mercaptobenzimidazole (MMBI), respectively. These two compounds are used to prepare the compounds N3–N11. The synthesized compounds are characterized by physical and spectroscopic techniques. Molecular docking of synthesized compounds indicates that compound N5, N10, and N11 have good antitumor properties. Furthermore, the theoretical studies prove that all the synthetic compounds in the study showed good lipophilicity, with a range of 0.132–3.739.
Benzimidazole Macromolecules from 2‐Mercaptobenzimidazole: Synthesis, Characterization, and Molecular Docking Studies
Authors: Alheety Nuaman F. , Mssdf Abdulrahman Khalid , Alheety Ahmed J. M. , Aldahham Bilal J M , Raouafi Noureddine , Alheety Mustafa A. , Besbes Rafaâ 
Published: February 2025

AbstractThe research involves the preparation of 2–hydrazinobenzoimidazole (N1) from the reaction of the compound 2‐tetrabenzoimidazole with aqueous hydrazine. A number of hydrazones (N2, N3) are prepared by the reaction of the compound (N1) with benzaldehyde derivatives. Thiazolidinone (N4) is also prepared by cyclization of the hydrazone compound (N3) using thioglycolic acid. As for the compound (N5), it is obtained from the reaction of the compound 2‐mercaptobenzimidazole with ethyl chloroacetate in the presence of alcoholic potassium hydroxide. The newly synthesized compounds show a very good interaction through the docking score compared to co‐crystalline ligand of each protein and in the same time the docking score is better than approved antibiotic in some cases. Furthermore, the study concluded that the compound N2 displayed the best and safest docking specifications out of all the compounds.