bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility preservation in Hong Kong Chinese society: awareness, knowledge and acceptance
Authors: YEUNG Suet Ying , Ng Elaine Yee Lee , LAO Terence Tzu Hsi , Li Tin Chiu , CHUNG Jacqueline Pui Wah 
Published: April 2020

AbstractBackgroundFertility preservation for both medical and non-medical reasons are gaining increasing attention world-wide. This study aimed to evaluate the awareness, knowledge and acceptance on fertility preservation in Hong Kong Chinese.MethodsThis was a cross-sectional study carried out between June 2016 to March 2017. A self-administered questionnaire was distributed by convenience sampling.ResultsForty two percent of subjects returned the questionnaire (n = 296/697). Among them, only 54.3% were aware of any means of fertility preservation. Tertiary educated individuals are more aware than less educated individuals (73.6% versus 46.6%,p < 0.001). The most commonly known method is oocyte cryopreservation (94.3%). Most of the respondents (80%) were interested to know about fertility preservation, 84.1% considered fertility preservation counselling necessary and 83.3% would consider undergoing fertility preservation if a treatment has a high chance of causing infertility despite the possibility of delay in cancer treatment. Up to 93.9% agreed to set up a dedicated referral centre with government funding and 73.4% agreed that fertility preservation for medical indication should be provided as a government funded service. In terms of fertility preservation for non-medical reason, 65.5 and 70.4% agreed that fertility preservation should be offered to single men and women without partner respectively, while only 53.3 and 50% agreed that fertility preservation is acceptable for delay in childbearing for career development in female and male respectively.ConclusionThere was a low awareness but positive attitude towards fertility preservation among Hong Kong Chinese. Acceptance towards medically indicated fertility preservation is high while a considerable number also accepts it for non-medical reasons. Educational campaigns are required to arouse awareness of fertility preservation to prevent individuals being deprived of the option due to lack of knowledge. Dedicated referral centre with established efficient patient referral pathways and financial support should be provided to improve the provision and uptake of fertility preservation service to enhance the reproductive potential and life options of women.
Evaluation of efficacy and safety of DPP-4 inhibitors for Chinese elderly patients with type 2 diabetes mellitus
Authors: Yu Dong-Ni , Qiu Lei , Ning Shang-Yong , Guo Li-Xin 
Published: April 2020

Abstract
Background
The safety of hypoglycemic drugs should be paid more attention to in elderly patients with type 2 diabetes mellitus due to their concomitant diseases, physiological decline of liver and kidney function and cognitive decline. The aim of this study was to evaluate the efficacy and safety of DPP-4 inhibitors in elderly patients with type 2 diabetes mellitus.

Methods
From January 2010 to November 2018, 300 patients with type 2 diabetes mellitus who were over 60 years old were enrolled in the outpatient clinic of Geriatric Medical Center. Their medication records and follow-up medical records were used for retrospective analysis. The duration of treatment with DPP-4 inhibitors was more than 3 months. The changes of fasting blood glucose (GLU), glycosylated hemoglobin (HbA1C), body weight, body mass index (BMI) and liver and kidney function were compared before and after treatment.

Results
The average age of 300 patients (212 males and 88 females) was 73.7 ± 9.1 years old, BMI was 26.5 ± 2.8 kg/m2 and the duration of diabetes was 10.7 ± 8.2 years. The results of retrospective analysis showed that HbA1C decreased by 0.27% after treatment (P < 0.001). In the group of DPP-4 inhibitors used for less than 12 months, there was no difference in liver transaminase (ALT and AST) between before and after treatment, whereas in the group of DPP-4 inhibitors used formore than 12 months, liver transaminase decreased statistically compared with after treatment (P < 0.001). The incidence of fatty liver in elderly diabetic patients decreased after using DPP-4 inhibitors. There was no significant change in serum creatinine level and creatinine clearance rate in elderly patients with type 2 diabetes mellitus after treatment of DPP-4 inhibitor. In addition, the body weight and BMI of the patients decreased significantly (P < 0.001). No hypoglycemic reaction and gastrointestinal discomfort were found in the medical records.

Conclusion
After DPP-4 inhibitors were used in elderly patients with type 2 diabetes mellitus, the elevated glycosylated hemoglobin could be controlled with improved safety of liver and kidney, and might have the effect of weight loss.
Temporomandibular joint disc plication with MITEK mini anchors: surgical outcome of 65 consecutive joint cases using a minimally invasive approach
Authors: Lee Bu-Kyu , Hong Jun Hee 
Published: April 2020

Abstract
Background
The purpose of this study is to introduce our modified disc plication technique using MITEK mini anchors and to evaluate the clinical outcome for patients with internal derangement (ID) of the temporomandibular joint (TMJ).

Patients and methods
We evaluated 65 joints in 46 patients, comprised 32 women and 14 men, who first visited the Asan Medical Center from December 2012 to December 2016. The age of the patients ranged from 14 to 79 years, with a mean age of 36.6 years. The patients presented with joint problems including pain, joint noise, and mouth opening limitation (MOL). Patients who met our inclusion criteria underwent unilateral or bilateral disc repositioning surgery with our minimally invasive disc plication technique using MITEK mini anchors and No. 2-0 Ethibond® braided polyester sutures. The variables taken into account in this study were the range of maximum mouth opening (MMO), painful symptoms (evaluated with the visual analog scale, VAS), and the type of noise (click, popping, crepitus) in the TMJ.

Results
Preoperative examination revealed painful symptoms in 50.7% (n = 35) of the operated joints (n = 69) and the presence of clicks in 56.5% (n = 39). Postoperative examination revealed that 4.3% (n = 3) of the operated joints had painful symptoms with lower intensity than that in the preoperative condition. Additionally, 17.4% (n = 12) had residual noise in the TMJ, among which two were clicking and the other 10 had mild crepitus. The intensity of the postoperative residual noise was significantly decreased in all cases compared to that in the preoperative condition. Among patients with MOL below 38 mm (n = 18), the mean MMO was 31.4 mm preoperatively and 44.2 mm at 6 months postoperatively, with a mean increase of 13.8 mm. A barely visible scar at the operation site was noted during the postoperative observation period, with no significant complications such as facial palsy or permanent occlusal disharmony.

Conclusion
Subjective symptoms in all patients improved following the surgery. TMJ disc plication using MITEK mini anchors with our minimally invasive approach may be a feasible and effective surgical option for treating TMJ ID patients who are not responsive to conservative treatment.
Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response
Authors: Hatzimanolis Alex , Stefanatou Pentagiotissa , Kattoulas Emmanouil , Ralli Irene , Dimitrakopoulos Stefanos , Foteli Stefania , Kosteletos Ioannis , Mantonakis Leonidas , Selakovic Mirjana , Soldatos Rigas-Filippos , Vlachos Ilias , Xenaki Lida-Alkisti , Smyrnis Nikolaos , Stefanis Nicholas C. 
Published: April 2020

AbstractBackground.Premorbid adjustment (PA) abnormalities in psychotic disorders are associated with an earlier age at onset (AAO) and unfavorable clinical outcomes, including treatment resistance. Prior family studies suggest that familial liability, likely reflecting increased genetic risk, and socioeconomic status (SES) contribute to premorbid maladjustment. However, their joint effect possibly indicating gene–environment interaction has not been evaluated.Methods.We examined whether family history of psychosis (FHP) and parental SES may predict PA and AAO in unrelated cases with first-episode psychosis (n= 108) and schizophrenia (n= 104). Premorbid academic and social functioning domains during childhood and early adolescence were retrospectively assessed. Regression analyses were performed to investigate main effects of FHP and parental SES, as well as their interaction. The relationships between PA, AAO, and response to antipsychotic medication were also explored.Results.Positive FHP associated with academic PA difficulties and importantly interacted with parental SES to moderate social PA during childhood (interactionp= 0.024). Positive FHP and parental SES did not predict differences in AAO. Nevertheless, an earlier AAO was observed among cases with worse social PA in childhood (β= −0.20;p= 0.005) and early adolescence (β= −0.19;p= 0.007). Further, confirming evidence emerged for an association between deficient childhood social PA and poor treatment response (p= 0.04).Conclusions.Familial risk for psychosis may interact with parental socioeconomic position influencing social PA in childhood. In addition, this study supports the link between social PA deviations, early psychosis onset, and treatment resistance, which highlights premorbid social functioning as a promising clinical indicator.
What gastroenterologists should know during COVID-19 Pandemic!
Authors: Kamani Lubna 
Published: April 2020

The WHO has declared a Pandemic due to Novel Corona virus-19 (COVID-19). Patients usually have respiratory symptoms but gastrointestinal and hepatic dysfunction are not uncommon presentations and can lead to a delay in diagnosis and management. Virus shedding can continue even after the nasopharyngeal swab gets negative and could lead to faecal-oral transmission. The effects of COVID-19 on patients with decompensated liver disease is still not clear. Managing immunosuppressive drugs in liver transplant and inflammatory bowel disease is a major challenge without clear guidelines. Only emergency endoscopy is to be done with personal protection equipment. Chloroquine and Hydroxychloroquine has shown some beneficial effects and is being used off-label. Without effective treatment, it is imperative to take precautionary measures.
doi: https://doi.org/10.12669/pjms.36.COVID19-S4.2651
How to cite this:Kamani L. What gastroenterologists should know during COVID-19 Pandemic! Pak J Med Sci. 2020;36(COVID19-S4):COVID19-S124-S125. doi: https://doi.org/10.12669/pjms.36.COVID19-S4.2651
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Immediate Results of a Prolonged Course of Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Rectal Cancer: a Comparison of Classical and Hypofractional Regimes
Authors: Abdujapparov A. , Tkachev Sergey , Aliev V. , Romanov D. , Nazarenko A. , Barsukov Yu. , Borisova T. , Glebovskaya V. 
Published: April 2020

Purpose: To compare the effectiveness of the hypofractional and classical modes of radiation therapy in a neoadjuvant prolonged course of chemoradiotherapy for patients with locally advanced rectal cancer (LARC).
Material and methods: This work is based on a retrospective analysis of the database of patients with LARC, who from 2013 to 2017 underwent a prolonged course of neoadjuvant chemoradiotherapy with subsequent surgical intervention. Patients were divided into two groups: the first (main) group, 71 patients with LARC, who, as part of the neoadjuvant treatment, underwent a course of chemoradiotherapy (CRT) in the hypofractionation mode (4 Gy, 3 fractions per week, 32 Gy to regional lymph nodes pelvis and up to 40 Gy to the primary tumor) in combination with chemotherapy with capecitabine 1650 mg/m2 in two doses daily on weekdays. The second group (control group) included 79 patients with LARC, who underwent CRT in the classical fractionation regimen (2 Gy, 5 fractions per week, 44 Gy to regional pelvic lymph nodes and up to 50–58 Gy to the primary tumor) in combination with capecitabine chemotherapy 1650 mg/m2 in two doses on the days of radiation therapy.
Results: The average duration of a prolonged course of CRT in the main group was 22.56 (95 % CI from 21.94 to 23.18) calendar days, in the control group — 38.84 (95 % CI from 38.12 to 39.54), p = 0.0001. Pathological response of the III degree in the main group was recorded in 23 % of cases, and of the IV degree in 18 %, in the control group these indicators were 19 % and 15 %, respectively, p = 0.4. A decrease in the stage of the tumor process was recorded in 50 (70.4 %) cases in the main group and in 47 (59.5 %) cases in the control group, p = 0.16. No statistically significant differences were observed in the incidence and severity of cases of hematological and local toxicity.
Conclusion: The results of our study confirm that the use of a prolonged course of neoadjuvant chemoradiotherapy in hypofractionation mode does not worsen oncological results, does not increase the frequency and severity of early and late radiation injuries, but at the same time reduces the duration of the course of treatment by two weeks. The hypofractionation regimen can be considered as an alternative and not inferior to the classical regimen in the neoadjuvant course of CRT of patients with LARC.
Evaluation of the SPECT/CT Method in the Diagnosis of Ochronosis. Clinical Case
Authors: Ryzhkov A. , Krylov A. , Bludov A. , Kuzin A. , Kaspshik S. , Dolgushin M. 
Published: April 2020

Purpose: Is to demonstrate functional and structural changes in the musculoskeletal system of the patient with ochronosis using bone scan and hybrid imaging consisting of single-photon emission computed tomography (SPECT) and X-ray transmission computed tomography (CT) scan (SPECT/CT).
Material and methods: A clinical case report of patient with ochronosis, examined with bone scan and SPECT/CT.
Results: In this article we show a clinical case with the picture of mineral metabolism disorder and severe degenerative changes of musculoskeletal system in patient with ochronosis (a genetically determined disease), caused by metabolic disorders of homogentisic acid. We used hybrid SPECT/CT method for evaluation of this disease.
Conclusion: SPECT/CT method demonstrated structural and metabolic changes. This method allowed us to reveal the specific changes in cases of ochronosis, but also it shows the possibility of using radionuclide methods in solving non-standard situations, while this method has not previously been applied.
A helping hand
Authors: McLaughlin Amanda 
Published: April 2020

Amanda McLaughlin considers the importance of oral health care in nursing and residential care homes Aim The reader should be able to understand the importance of introducing and maintaining effective oral health care in nursing and residential care home and nursing home settings. Objectives To have an overview of UK statistics. To understand the implications of poor oral health on overall wellbeing To understand ways in which teams can improve the oral health of the elderly.
Resumos da 2ª Mostra de Doutoramento em Psicologia
Authors: FPCE Universidade Coimbra 
Published: April 2020

A 2ª Mostra de Doutoramento em Psicologia consistiu numa sessão de posters, em que as/os doutorandas/os em Psicologia na FPCE-UC apresentaram e discutiram as investigações que estão a fazer no âmbito dos seus trabalhos de doutoramento. Todas/os doutorandas/os em Psicologia na FPCE-UC foram convidadas/os a participar, independentemente da fase em que se encontrava o desenvolvimento das suas teses e os resumos submetidos foram sujeitos a um processo de avaliação pela Comissão Científica.
Esta Mostra fez-se na continuidade da 1ª Mostra de Doutoramento em Psicologia/PsihD que se realizou em 2017 (a 6 de Novembro), com uma Comissão Organizadora composta exclusivamente por estudantes de doutoramento em Psicologia na FPCE-UC. O programa inicial da 1ª Mostra de Doutoramento em Psicologia/PsihD incluía uma Conferência e uma tertúlia sobre o Doutoramento em Psicologia. A Direcção da FPCE-UC não só deu o apoio logístico e financeiro à 1ª Mostra de Doutoramento em Psicologia/PsihD como decidiu incluí-la no Dia da Faculdade, que assinalava o 37º aniversário da FPCE-UC e dos 40 anos do curso Superior de Psicologia na Universidade de Coimbra. Assim, a Conferência do Dia da Faculdade, em 2017, Can Psychology Save Democracy (Prof. Fathali Moghaddam, Georgetown University) foi também a Conferência da 1ª Mostra de Doutoramento em Psicologia/PsihD. As/os doutorandas/os que apresentaram posters nessa Mostra foram convidados a submeter os respectivos resumos para publicação na Psychologica. Após um novo processo de revisão, esses resumos foram publicados no volume 62, número 1, da Psychologica.
Mantendo a estrutura do ano anterior, a 2ª edição da Mostra de Doutoramento em Psicologia, inseriu-se no PsihDay, que decorreu a 31 de Outubro de 2018, um dia dedicado ao doutoramento em Psicologia na FPCE-UC, no âmbito das comemorações do 38º aniversário da FPCE-UC, e que incluiu a Conferência do Prof. Mathias Reitzle (Universidade de Jena Friedrich Schiller) Some Notes on Developmental Processes Versus Longitudinal Prediction e a Tertúlia Percursos de Doutoramento: Obstáculos e/ou Oportunidades? Tal como no ano anterior, a Comissão Organizadora foi composta exclusivamente por estudantes de doutoramento em Psicologia. Os resumos aqui publicados foram alvo de um novo processo de revisão por dois editores da Psychologica. Nem todos os trabalhos apresentados puderam fazer parte desta publicação por diferentes razões, designadamente, porque os seus autores entretanto submeteram já as suas investigações completas para publicação. A todas/os as/os que participaram na 2ª Mostra de Doutoramento em Psicologia, deixamos aqui expressos os nossos agradecimentos.
COMISSÃO CIENTÍFICA ǁ Coordenador do Doutoramento em Psicologia, (Joaquim Pires Valentim) e membros da Comissão de Coordenação do Doutoramento em Psicologia (Maria Cristina Canavarro, Maria Paula Paixão, Maria Salomé Pinho, Teresa Rebelo e Bruno Cecílio de Sousa)
COMISSÃO ORGANIZADORA ǁ Ana Laura Mendes, Ana Rita Martins, Diogo Carreiras, Francisca Duarte, Joana Simões, Julieta Azevedo e Maria João Martins.
Lições sobre a Pandemia da COVID-19 e a Informação Científica
Authors: Barbosa Allan Claudius Queiroz 
Published: April 2020

Este artigo sugere aspectos associados à produção científica associados à pandemia de saúde causada pelo COVID-19, sendo esta uma das dimensões engajada no esforço e compromisso de pesquisadores com a ciência e o conhecimento, manancial confiável e seguro em momentos de turbulência e fortes divergências.
Encaminhamento de estudantes com deficiência aos serviços de Educação Especial em Manaus: quais os critérios?
Authors: Galvani Márcia Duarte , Vinente Samuel 
Published: April 2020

O presente estudo objetivou analisar os critérios no encaminhamento de estudantes com deficiência aos serviços de Educação Especial em Manaus. Trata-se de um estudo descritivo, com utilização das técnicas de entrevista e pesquisa documental. Utilizou-se como instrumento roteiros semistruturados de entrevista a quatro professores (P1, P2, P3 e P4) e um representante da Gerência de Educação Especial (P5). A pesquisa documental foi realizada na legislação municipal publicada entre 1991 e 2017. Os resultados apontam que o encaminhamento desses estudantes aos serviços de Educação Especial é realizado mediante avaliação multidisciplinar de profissionais do Complexo Municipal de Educação Especial, focalizando-se mais em uma abordagem médico-clínica que na perspectiva pedagógica e dos direitos humanos. Os critérios de identificação, avaliação e encaminhamento dos estudantes com deficiência precisam ser delineados, considerando as especificidades dos alunos e a questão do direito educacional na oferta desses serviços.
Matemática do mundo da vida: abordagem metodológica nos anos iniciais do Ensino Fundamental da Educação de Jovens e Adultos
Authors: Costa Célia Souza da , Cordeiro Gisele do Rocio , Bentes Liana da Costa Ferreira 
Published: April 2020

A Educação de Jovens e Adultos é uma modalidade de ensino carregada de especificidades, pois o público atendido é diversificado, jovem, adulto e trabalhador geralmente marcados por percalços que dificultaram acesso à educação na idade ideal. Este artigo tem como objetivo discutir como uma abordagem metodológica diferenciada a partir do mundo da vida pode fazer a diferença no ensino da matemática para os estudantes da EJA. Realizou-se uma pesquisa bibliográfica com abordagem qualitativa considerando as contribuições de autores como Januario (2012, 2014 e 2017), Souza (2012), Sampaio (2009), Basegio e Borges (2013) e Hirye et al. (2016), entre outros, procurando enfatizar a importância de uma abordagem metodológica na Educação de Jovens e Adultos, no ensino da Matemática. Concluiu-se que há a necessidade de uma abordagem metodológica diferenciada, no qual o docente poderá adequar a metodologia de acordo com o perfil do alunado e com os saberes prévios, o conhecimento do mundo da vida.
AKTIVITAS ANTIOKSIDAN, KADAR PATI RESISTEN, DAN ORGANOLEPTIK ES KRIM PISANG BATU (Musa Balbisiana Colla) SEBAGAI MAKANAN FUNGSIONAL UNTUK PENCEGAHAN PENYAKIT KANKER KOLOREKTAL
Authors: Ahsin Almuthya , Wijayanti Hartanti Sandi , Afifah Diana Nur 
Published: April 2020

Latar Belakang: Kanker kolorektal dapat disebabkan karena berlebihnya produksi radikal bebas atau kurangnya antioksidan dalam tubuh. Kandungan pati resisten dan aktivitas antioksidan pada pisang batu dapat memberikan pencegahan penyakit kanker kolorektal.Tujuan: Penelitian ini bertujuan untuk menganalisis kandungan aktivitas antioksidan, kadar pati resisten dan organoleptik es krim pisang batu sebagai makanan fungsional untuk pencegahan penyakit kanker kolorektal. Metode: Penelitian eksperimental acak lengkap dua faktor meliputi kadar tepung pisang batu, yaitu 12% dan 17% serta variasi cara penambahan, yaitu pada saat pemasakan dan pendinginan. Analisis aktivitas antioksidan menggunakan metode DPPH dan kadar pati resisten menggunakan metode Kim et al. Analisis statistik aktivitas antioksidan dan kadar pati resisten menggunakan uji one way Anova, Kruskall-Wallis dan tukey. Analisis organoleptik menggunakan uji Kruskall-Wallis dan mann withney. Hasil:. Aktivitas antioksidan tertinggi didapatkan pada es krim dengan penambahan tepung pisang batu 17% dan yang ditambahkan ketika pendinginan. Kadar pati resisten tidak menunjukkan beda secara statistik, walaupun didapatkan kadar pati resisten lebih tinggi yang ditambahkan ketika pemasakan. Terdapat perbedaan signifikan pada uji organoleptik aroma dan rasa dengan yang paling disukai es krim dengan kadar 12% untuk aroma dan es krim dengan cara penambahan saat pendinginan untuk rasa.Simpulan: Terjadi peningkatan aktivitas antioksidan seiring banyaknya tepung pisang batu yang digunakan dan ditambahkan ketika proses pendinginan. Produk terbaik yang direkomendasikan adalah es krim yang diberikan tepung pisang batu dengan kadar 17% dan ditambahkan saat pendinginan.