bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high mitotic score in breast cancer after neoadjuvant chemotherapy is predictive of outcome and associated with a distinct morphology
Authors: Arispe Angulo Karen R , Jawa Zeeshan , Visotcky Alexis , Majidi Shadie S , Chitambar Christopher R , Jorns Julie M 
Published: December 2019

AimsNeoadjuvant chemotherapy (NAC) is frequently used for the treatment of breast cancer. We sought to analyse the clinical, morphological and immunohistochemical features of tumours from patients who did not achieve pathological complete response following NAC.Methods and resultsWe identified stage I–III post‐NAC breast cancers from surgical resections (2000–2016) with evaluable residual invasive carcinoma [ypT1a(m) or greater and ≥15% tumour cellularity]. One hundred and forty‐three tumours from 142 patients were included. On univariable analysis, a high (score 3) post‐NAC mitotic score (as compared with 1 or 2) was significantly associated with invasive ductal carcinoma (IDC) subtype (P = 0.023), high grade, pushing borders with zones of necrosis, hormone receptor and triple‐negative status, lack of hormonal therapy, higher cellularity (P < 0.001), and a higher percentage of tumour‐infiltrating lymphocytes (P = 0.016). Multivariable analysis showed a high post‐NAC mitotic score to be significantly associated with recurrence, distant metastasis, and shortened survival (hazard ratios of 5.73, 4.49, and 3.68, respectively). High post‐NAC mitotic score tumours (n = 32) were IDC and had a high Ki67 proliferation index (median, 55%). Of these, 24 (75%) had pushing borders with zones of necrosis; 19 (79.2%) of these had necrosis on preoperative imaging, and 24 (75%), 15 (46.9%) and four (12.5%) lacked androgen receptor, GATA‐3 and cytokeratin 18 expression, respectively.ConclusionsHigh post‐NAC mitotic score breast cancers cause high morbidity and mortality, frequently have pushing borders and zones of necrosis, and may show loss of common ‘breast cancer markers’. Our findings support that necrosis in pretreatment studies and post‐NAC mitotic score should be routinely reported, as they offer significant additional prognostic information to guide management.
Chemsex drugs on the rise: a longitudinal analysis of the Swiss HIV Cohort Study from 2007 to 2017
Authors: Hampel B , Kusejko K , Kouyos RD , Böni J , Flepp M , Stöckle M , Conen A , Béguelin C , Künzler‐Heule P , Nicca D , Schmidt AJ , Nguyen H , Delaloye J , Rougemont M , Bernasconi E , Rauch A , Günthard HF , Braun DL , Fehr J ,   for the Swiss HIV Cohort Study group
Published: December 2019

ObjectivesChemsex refers to the use of sex‐enhancing drugs among men who have sex with men (MSM) in combination with specific sexual and social behaviours. Longitudinal data on this development and the associated health risks are scarce.MethodsData on all recreational drugs reported in the Swiss HIV Cohort Study (SHCS) from 2007 to 2017 were collected. Drug use was analysed longitudinally for all drug classes. In addition, potential associations between patient characteristics and the consumption of methamphetamine, γ‐hydroxybutric acid/γ‐butyrolactone (GHB/GBL), 3,4‐methylenedioxymethamphetamine (MDMA/XTC), cocaine and amphetamine were analysed.ResultsWe analysed 166 167 follow‐up entries for 12 527 SHCS participants, including 7101 free text field entries containing information about recreational drugs other than cannabis, cocaine and heroin. Overall, we observed a stable percentage (9.0%) of recreational drug use (excluding cannabis, amyl nitrite and prescription drugs). For MSM, however, there was an increase in overall drug use from 8.8% in 2007 to 13.8% in 2017, with particularly large increases for methamphetamine (from 0.2 to 2.4%; P < 0.001) and GHB/GBL (from 1.0 to 3.4%; P < 0.001). The use of each of the potentially sex‐enhancing drugs methamphetamine, GHB/GBL, cocaine, XTC/MDMA and amphetamine was significantly associated with condomless sex with nonsteady partners, and higher prevalences of depression, syphilis and hepatitis C.ConclusionsThe significant increase in the use of chemsex drugs among MSM in the SHCS and the strong association with coinfections and depression highlights the need for harm reduction programmes tailored to MSM. According to our results, improving knowledge about recreational drugs is important for all health care professionals working with people living with HIV.
Geochemistry, zircon U–PB ages and HF isotopes of the Muong Luan granitoid pluton, Northwest Vietnam and its petrogenetic significance
Authors: Hieu Pham T. , Anh Nong T. Q. , Minh Pham , Thuy Nguyen T. B. 
Published: December 2019

AbstractThe Indosinian Orogeny plays a significant role in tectonic background and magmatic evolution in Indochina and surrounding regions. Being a part product of the Indosinian magmatism in northwest Vietnam during late Permian–middle Triassic period, Muong Luan granitoid pluton dominantly consists of granodiorite, less diorite and granite. This pluton is located in the Song Ma suture and assigned to the Dien Bien complex. Geochemically, the Muong Luan granitoid rocks are characterized by a wide range of SiO2 contents (59.9–75.1 wt%) and high K2O contents. They display typical features of I‐type granites. The presence of hornblende and no muscovite and cordierite in the rocks further supports for I‐type character of granitoids. The emplacement age of the Muong Luan pluton obtained by LA–ICP–MS U–Pb zircon is at 242–235 Ma, corresponding to Indosinian time. Zircon εHf values of –5.6 to –10.4, in combination with moderate Mg values of 34–45 suggested that the Muong Luan granitoid was derived from partial melting of mafic crustal source rocks, which are probably Paleoproterozoic in age as revealed by Hf model ages (TDM2 = 1624–1923 Ma).
Community supported agriculture membership: The benefits of spousal involvement
Authors: Birtalan Ilona Liliána , Neulinger Ágnes , Rácz József , Bárdos György 
Published: December 2019

AbstractFresh vegetables originating from alternative food networks (AFNs) are an increasingly popular choice all over the world. Being part of an AFN frequently redefines consumption and participation of family members in food‐related activities. Community Supported Agriculture (CSA) is a type of AFN, providing increased access to produce in a form of risk‐sharing model between farmers and consumers, which at the same time influences organization of household resources. Thus, not only the given member of a CSA, but also his/her spousal activities in household processes should be taken in account. It is clear that entering into CSA significantly affects lifestyles and frequently requires a great deal of adaptation, possibly leading to a crisis of whether to stay within the CSA or cease membership. The objective of this study was to reveal how spouses influence CSA membership. Using an explorative design, this study has identified three emerging patterns of spousal influence: coherent, integrative and neutral/antagonistic. The spousal influence on CSA membership may represent partner activities regarding food issues but also has an effect on food preparation and culinary choices at home. Our findings suggest that membership in CSA presents challenges and thus spousal support is crucial in the long term. As a consequence, spousal influence should be examined in relation to CSA participation. Inconveniences associated with CSA membership could be avoided by providing more information about the importance of spousal support.
Foreign Remittances and Regional Poverty: Evidence from Household Data
Authors: Imran Kashif , Devadason Evelyn S. , Kee Cheok Cheong 
Published: December 2019

AbstractThis study examines the association between foreign remittances and poverty (incidence and severity) in the Punjab province of Pakistan. Logit regression is used to deal with binary headcount ratio, while the instrumental variable approach is employed to avoid possible endogeneity. Household‐based data, covering more than 40,000 household units in Punjab, are used for the empirical estimations. After controlling for several variables, such as the number of dependents of households, age, gender, and education of the household head, the results indicate that foreign remittances’ inflow reduces the incidence and severity of poverty in all three regions of the Punjab province, North Punjab, South Punjab and Central Punjab. The South Punjab, however, is found to be poorer based on headcount poverty and severity of poverty as compared to the other two regions.
Natural history of dental caries: Baseline characteristics of the VicGen birth cohort study
Authors: Chattopadhyay Amit , Christian Bradley , Masood Mohd. , Calache Hanny , Carpenter Lauren , Gibbs Lisa , Gussy Mark 
Published: December 2019

AbstractBackgroundEarly‐life dental caries is a major global health problem. Children's first dental visit is recommended at 2 years age. The VicGeneration (VicGen) oral health birth cohort study aims to understand the multifactorial nature of early childhood caries. This report describes the baseline characteristics of children in the VicGen study.MethodsWe merged data between the first (at birth) and fourth waves (18 month age) to assess dental caries among children (primary outcome) and other oral diseases (secondary outcomes) employing t tests, chi‐square tests, Fisher's exact tests, and Cochran‐Mantel‐Haenszel tests using IBM‐SPSS(v25).ResultsMost children lived in metros with two‐parent families. Most guardians were women graduated from high school. Twenty‐seven of 389 (6.94%) 18‐month‐old children experienced dental caries. More children living in rural areas (vs. urban) experienced caries. Females were more likely to experience caries (OR: 2.16). Several children had other oral health problems. In early life, children's oral examination was conducted by midwives, breastfeeding/lactation consultants, hospital nurses, speech pathologists, and breastfeeding clinic staff.ConclusionVicGen baseline characteristics show that almost 7% of the 18‐month‐old children experienced caries. There is a need to advance children's recommended first dental visit date and to train early‐life healthcare professionals about oral diseases.
Do current‐year forecasts deserve investors' exclusive attention among analyst estimates?
Authors: Huang Cheng‐tsu , Chang Chu‐hsuan , Lin Hsiou‐wei 
Published: December 2019

AbstractThis study demonstrates that in using security forecasts for equity valuation, it would be preferable to take into consideration of analyst multi‐year forecasts instead of exclusively employing current‐year earnings forecast because the latter forecast measure most typically incorporates non‐recurring and/or value‐irrelevant components of accounting earnings. In contrast, the same analyst's concurrent long‐term earnings estimates appear to be free from the influence of the non‐recurring earnings items. Namely, when a firm's long‐run profitability differs from current year earnings, long‐horizoned analyst forecasts add to identify the differences.
Communicative abilities in young children with a significant cognitive and motor developmental delay
Authors: Dhondt Ann , Van keer Ines , van der Putten Annette , Maes Bea 
Published: December 2019

AbstractBackgroundChildren with a significant cognitive and motor developmental delay are pre‐symbolic communicators. The primary aim of this study was to reveal the variability within the communicative functioning of this group of children in terms of communication level, the reasons to communicate and behavioural expressions.MethodsTwenty‐six children between 14 and 58 months with a significant cognitive and motor developmental delay were recruited. The Communication Matrix of Rowland (2011, Communication Disorders Quarterly, 32, 190) was used to integrate different sources of information on the children's communicative functioning.ResultsThese children primarily communicated at the level of pre‐intentional and intentional behaviour, aimed at refusing, obtaining and, to a lesser extent, social purposes.ConclusionsTo develop or adapt early intervention strategies, and to monitor progress in communicative development, an even more nuanced view on these children's communicative utterances in terms of frequency, duration, idiosyncrasy and context relatedness is needed.
Neotropical migratory and resident birds occurring in sympatry during winter have distinct haemosporidian parasite assemblages
Authors: Soares Leticia , Latta Steven C. , Ricklefs Robert E. 
Published: December 2019

AbstractAimWe compared the parasite assemblages of over‐wintering migratory birds and permanent residents on the wintering grounds. We determined whether parasite sharing between migratory and resident birds is influenced by host phylogenetic relatedness. We then inferred whether migratory birds transport haemosporidian parasite lineages between the breeding and wintering grounds.LocationSierra de Bahoruco National Park, Dominican Republic, Hispaniola.TaxaMigratory and resident birds (primarily Aves: Passeriformes) and their haemosporidian parasites (order Haemosporida, Plasmodium, Haemoproteus and Parahaemoproteus).MethodsWe used mist nets to capture birds in thorn scrub, broadleaf dry forests and pine forests during midwinter. We used molecular methods to recognize haemosporidian parasites in blood samples, and genotyped infections based on the nucleotide differences in a region of the parasite cytochrome b gene.Results and Main ConclusionWe identified 505 infections by 32 haemosporidian parasite lineages in 1,780 blood samples from 37 resident species, and in 901 blood samples from 14 overwintering migratory species, over five years at the same sites. Infection prevalence varied among migratory species from zero to 13%, whereas infection prevalence among resident species ranged up to 77%. Host relatedness did not predict parasite assemblage similarity. We discuss four hypotheses for the rarity of haemosporidian infections in migratory birds during winter, and for the infrequency of parasite sharing between migratory and resident birds: (a) relative abundance and host preferences of dipteran vectors lower parasite transmission to migratory birds; (b) parasite lineages adapted to infect endemic Caribbean hosts are unable to infect migratory species; (c) the physiology of migratory birds after migration and during winter reduces parasite survival; and (d) infected individuals suffer more pronounced mortality rates during migration. We highlight the link between host–parasite coevolution and the physiological adaptations associated with avian seasonal migration.
Long noncoding RNA ZFAS1 promotes tumorigenesis and metastasis in nasopharyngeal carcinoma by sponging miR‐892b to up‐regulate LPAR1 expression
Authors: Peng Jiaojiao , Liu Feng , Zheng Hong , Wu Qi , Liu Shixi 
Published: December 2019

AbstractObjectiveIn this study, we explored the NPC‐specific expression of ZFAS1 and the mechanism of ZFAS1‐mediated growth, aggressiveness and tumorigenesis in NPC.MethodsThe expression profile of lncRNAs was detected in NPC tissues and matching para‐carcinoma tissues using microarray analysis. LncRNA‐miRNA and miRNA‐mRNA interaction networks were constructed using the miRcode v11 and TargetScanHuman v7.2 web server and then validated using dual‐luciferase assay. Western blot and RT‐qPCR were performed to detect protein and RNA expression. The effects of ZFAS1, miR‐892b and LPAR1 dysregulation on the proliferative, migratory and invasive abilities of NPC cells were observed using colony formation, cell counting kit‐8 (CCK‐8) and transwell assays in vitro. In vivo, a xenograft nude mouse model was established to detect the impact of ZFAS1 dysregulation on the tumorigenicity of NPC cells.ResultsThe expression of multiple lncRNAs, of which ZFAS1 was up‐regulated, was dysregulated in NPC tissues. ZFAS1 directly targeted miR‐892b, and miR‐892b negatively regulated the expression of downstream LPAR1. The proliferation, migration and invasion of NPC cells could be largely enhanced by the downregulation of miR‐892b as well as the up‐regulation of ZFAS1 and LPAR1, while the overexpression of miR‐892b and the downregulation of ZFAS1 and LPAR1 decreased these abilities. In nude mice, the growth of tumour xenografts formed by HONE1 cells was significantly suppressed when ZFAS1 was silenced.ConclusionThe study demonstrated that lncRNA ZFAS1 may act as a promoter of tumorigenesis and metastasis in nasopharyngeal carcinoma, by up‐regulating the expression of LPAR1 in a miR‐892b‐dependent manner.
Failure mode and effects analysis for proactive healthcare risk evaluation: A systematic literature review
Authors: Liu Hu‐Chen , Zhang Li‐Jun , Ping Ye‐Jia , Wang Liang 
Published: December 2019

AbstractRationale, aims, and objectivesFailure mode and effects analysis (FMEA) is a valuable reliability management tool that can preemptively identify the potential failures of a system and assess their causes and effects, thereby preventing them from occurring. The use of FMEA in the healthcare setting has become increasingly popular over the last decade, being applied to a multitude of different areas. The objective of this study is to review comprehensively the literature regarding the application of FMEA for healthcare risk analysis.MethodsAn extensive search was carried out in the scholarly databases of Scopus and PubMed, and we only chose the academic articles which used the FMEA technique to solve healthcare risk analysis problems. Furthermore, a bibliometric analysis was performed based on the number of citations, publication year, appeared journals, authors, and country of origin.ResultsA total of 158 journal papers published over the period of 1998 to 2018 were extracted and reviewed. These publications were classified into four categories (ie, healthcare process, hospital management, hospital informatization, and medical equipment and production) according to the healthcare issues to be solved, and analyzed regarding the application fields and the utilized FMEA methods.ConclusionFMEA has high practicality for healthcare quality improvement and error reduction and has been prevalently employed to improve healthcare processes in hospitals. This research supports academics and practitioners in effectively adopting the FMEA tool to proactively reduce healthcare risks and increase patient safety, and provides an insight into its state‐of‐the‐art.
Performance assessment of medical diagnostic laboratories: A network DEA approach
Authors: Ghafari Someh Niloufar , Pishvaee Mir Saman , Sadjadi Seyed Jafar , Soltani Roya 
Published: December 2019

AbstractRationale, aims, and objectivesThe main purpose of this paper is to measure the efficiency and ranking of medical diagnostic laboratories by applying a network data envelopment analysis (NDEA).MethodsIn this study, each medical diagnostic laboratory is considered as a decision‐making unit (DMU), and an NDEA model is utilized to calculate the efficiency of each medical diagnostic laboratory. Therefore, we design a series of four‐stage system composed of three main laboratory processes (the pretest process, the test process, and the posttest process). We also consider sustainability criteria in order to cover social, economic, and environmental problems of health care organizations.ResultsThe results show that three of the 22 considered laboratories are efficient. Therefore, the NDEA approach can lead to performance scores and ultimately real ranking. Also, the average efficiency scores show that the decrease of the reception unit's efficiency results in a decrease of the efficiency of each laboratory. Therefore, the laboratories can increase the number of patients. Along with the intermediate values of the reception unit and the sampling unit, the efficiency of the reception unit increases, which results in an increase for the overall efficiency of each laboratory.ConclusionThe proposed model can appropriately help the administrators and managers to identify inefficient units in their laboratory and ultimately improve the laboratory performance.
Abscisic acid dynamics, signaling, and functions in plants
Authors: Chen Kong , Li Guo‐Jun , Bressan Ray A. , Song Chun‐Peng , Zhu Jian‐Kang , Zhao Yang 
Published: December 2019

AbstractAbscisic acid (ABA) is an important phytohormone regulating plant growth, development, and stress responses. It has an essential role in multiple physiological processes of plants, such as stomatal closure, cuticular wax accumulation, leaf senescence, bud dormancy, seed germination, osmotic regulation, and growth inhibition among many others. Abscisic acid controls downstream responses to abiotic and biotic environmental changes through both transcriptional and posttranscriptional mechanisms. During the past 20 years, ABA biosynthesis and many of its signaling pathways have been well characterized. Here we review the dynamics of ABA metabolic pools and signaling that affects many of its physiological functions.
Debt and Financial Vulnerability on the Verge of Retirement
Authors: LUSARDI ANNAMARIA , MITCHELL OLIVIA S. , OGGERO NOEMI 
Published: December 2019

AbstractWe analyze older individuals’ debt and financial vulnerability using data from the Health and Retirement Study (HRS) and the National Financial Capability Study (NFCS). In the HRS, we compare three groups of people age 56–61 in 1992, 2004, and 2010, to assess cross‐cohort changes in debt over time. Two waves of the NFCS (2012 and 2015) provide additional insights into debt management and older individuals’ capacity to shield themselves against shocks. We conclude that recent cohorts hold more debt and face more financial insecurity than in the past. This will render them particularly vulnerable to forecasted interest rate increases.
Observing and Shaping the Market: The Dilemma of Central Banks
Authors: BAERISWYL ROMAIN , CORNAND CAMILLE , ZILIOTTO BRUNO 
Published: December 2019

AbstractWhile the central bank observes market activity to assess economic fundamentals, it shapes the market outcome through the conduct of monetary policy. A dilemma arises from this dual role because the more the central bank shapes the market, the more it influences the informational content of market outcomes. This paper analyzes how accounting for the endogeneity of information affects optimal monetary policy. By reducing the accuracy of central bank information, endogenous information calls for a higher degree of opacity, weakens accommodation policy to shocks, and broadens the range of parameters for which taking a signaling action is detrimental to welfare.
Problems for the plantations: Challenges for large‐scale land concessions in Laos and Cambodia
Authors: Baird Ian G. 
Published: December 2019

AbstractLarge‐scale plantation land concessions are causing an array of serious social and environmental impacts in Southeast Asia as well as in other parts of the world. This paper, however, is focused on the many challenges and limitations that plantation developers face in southern Laos and northeastern Cambodia. These include price and market constraints, activism linked to villagers and others actors, management and financial difficulties, environmental and technical limitations, and limited government support. Investor responses to these challenges and limitations have varied. Some investors still hope that their plantations will succeed, while others have variously attempted to cut their losses and withdraw from failing investments. In particular, this paper considers how problems associated with plantation development often emerge due to fluctuating crop prices as well as poor planning that partially stems from investors adopting a “resource frontier” mindset.