bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the degrees of distortion in simulated human bite marks
Authors: Dama Neha , Forgie Andrew , Mânica Scheila , Revie Gavin 
Published: November 2019

Abstract
The properties of the skin and the posture of the body during photographic recording are factors that cause distortion in the bite mark injury. This study aimed to explore the degree of distortion between a ‘touch mark’ (method 1) and a ‘bite mark’ (method 2) on the left upper arm at three different positions (arm relaxed; arm flexed in two different positions). A pair of dental casts with biting edges coated in ink was used to create a mark in 30 subjects (6 ♂, 24 ♀) aged 20–50 years old. Photographs were taken using a Nikon DX digital camera (D5000). The mesiodistal widths and angle of rotations of both upper right central incisor and lower right central incisor and the inter-canine distances were analysed and compared with the true measurements using Adobe Photoshop CC 2017. Statistical analysis was carried out using SPSS Statistics 22 applying a 2 (mark type) × 3 (position) repeated measures ANOVA. For all measures studied, there was a statistically significant difference between mark types and positions. In the case of bite marks, a great degree of distortion was detected, and this increased further when changing the position of the arm. The findings demonstrated that skin properties and posture influence distortion. This could lead to inaccurate measurements and misleading pattern interpretation of bite mark injuries.
Cause of death and significant disease found at autopsy
Authors: Friberg Niklas , Ljungberg Oscar , Berglund Erik , Berglund David , Ljungberg Richard , Alafuzoff Irina , Englund Elisabet 
Published: November 2019

Abstract
The use of clinical autopsy has been in decline for many years throughout healthcare systems of developed countries despite studies showing substantial discrepancies between autopsy results and pre-mortal clinical diagnoses. We conducted a study to evaluate over time the use and results of clinical autopsies in Sweden. We reviewed the autopsy reports and autopsy referrals of 2410 adult (age > 17) deceased patients referred to two University hospitals in Sweden during two plus two years, a decade apart. There was a decline in the number of autopsies performed over time, however, mainly in one of the two hospitals. The proportion of autopsy referrals from the emergency department increased from 9 to 16%, while the proportion of referrals from regular hospital wards was almost halved. The autopsies revealed a high prevalence of cardiovascular disease, with myocardial infarction and cerebrovascular lesion found in 40% and 19% of all cases, respectively. In a large proportion of cases (> 30%), significant findings of disease were not anticipated before autopsy, as judged from the referral document and additional data obtained in some but not all cases. In accordance with previous research, our study confirms a declining rate of autopsy even at tertiary, academic hospitals and points out factors possibly involved in the decline.
Long-term quality of life after surgery of head and neck cancer with microvascular reconstruction: a prospective study with 4.9-years follow-up
Authors: Kainulainen Satu , Koivusalo A. M. , Roine R. P. , Wilkman T. , Sintonen H. , Törnwall J. , Thorén H. , Lassus P. 
Published: November 2019

AbstractPurposeThe aim of this study was to evaluate the long-term health-related quality of life (HRQoL) of head and neck cancer patients with microvascular surgery. Surgical treatment causes great changes in patient HRQoL. Studies focusing on long-term HRQoL after microvascular reconstruction for head and neck cancer patients are scarce.MethodsWe conducted a prospective study of 93 patients with head and neck cancer and microvascular reconstruction in Helsinki University Hospital Finland. HRQoL was measured using the 15D instrument at baseline and after a mean 4.9-years follow up. Results were compared with those of an age-standardized general population.ResultsOf the 93 patients, 61 (66%) were alive after follow-up; of these, 42 (69%) answered the follow-up questionnaire. The median time between surgery and HRQoL assessment was 4.9 years (range 3.7–7.8 years). The mean 15D score of all patients (n = 42) at the 4.9-years follow up was statistically significantly (p = 0.010) and clinically importantly lower than at baseline. The dimensions of “speech” and “usual activities” were significantly impaired at the end of follow up. There was a significant difference at the 4.9-years follow-up in the mean 15D score between patients and the general population (p = 0.014). After follow up, patients were significantly (p < 0.05) worse off on the dimensions of “speech,” “eating,” and “usual activities.”ConclusionsLong-term HRQoL was significantly reduced in the whole patient cohort. Speech and usual activities were the most affected dimensions in head and neck cancer patients with microvascular reconstruction at the end of the 4.9-years follow up.
Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch—a randomized clinical controlled trial
Authors: Matys Jacek , Jaszczak Elżbieta , Flieger Rafał , Kostrzewska-Kaminiarz Katarzyna , Grzech-Leśniak Kinga , Dominiak Marzena 
Published: November 2019

Abstract
The effect of ozone, diode laser irradiation, and presence of teeth crowding/spacing on pain perception in orthodontic patient was tested. Overall, 76 patients [55 women and 21 men; age 35.1(6.4) years] who met the inclusion criteria participated in the study. Immediately after fixed orthodontic appliance placement, the patients were exposed to a pain relief treatment (one single session) using either 635-nm diode laser (SmartM, Lasotronix, Warsaw, Poland) or ozone therapy (OzoneDTA, Apoza, New Taipei City, Taiwan) by placing the handpieces in the area of each teeth apex and interdental papillae, from the maxillary right first molar to the maxillary left first molar. Subjects were divided into three groups: control group (G1, n = 26), ozone (G2, n = 26, exposed to ozone therapy, generator probe type 3, working time per point 5 s, 23 points, application time 1 min and 55 s), and laser group (G3, n = 25, exposed to continuous mode diode laser, 400 mW, handpiece diameter 8 mm, spot area 0.5024 cm2, power density per second 1.59 W/cm2, dose 2 J per point, time: 5 s per point, 23 points, total energy per session 46 J, application time 1 min and 55 s). The level of teeth crowding was assessed using the Lundstrom indicator. The patients received a questionnaire for pain assessment (the Numeric Rating Scale, NRS-11, grade level 0–10) and recorded at 7 time points (1 h, 6 h, and 1, 2, 3, 4, and 5 days ) after the fixed orthodontic appliance placement. The mean pain values for the diode laser, ozone, and control group were 3.6 (1.31) (95% CI, 2.95–4.25), 5.25 (3.37) (95% CI, 3.52–6.98), and 5.75 (2.40) (95% CI, 4.69–6.81), respectively. We observed lower pain values in the diode laser group compared to the control group (p = 0.0237). The use of ozone in this study did not result in significant pain reduction in comparison to control (p = 0.8040) and laser groups (p = 0.1029). There were no differences in pain perception between patients with crowded teeth and non-crowded teeth in each group (G1, p = 0.66, G2, p = 0.86, G3, p = 0.24). The use of 635-nm diode laser led to decreased pain perception; however, ozone and presence of teeth crowding/spacing did not affect the pain perception in orthodontic patients during the first 5 days after the fixed orthodontic appliance placement.
Do food donation tax credits for farmers address food loss/waste and food insecurity? A case study from Ontario
Authors: Kinach Lesia , Parizeau Kate , Fraser Evan D. G. 
Published: November 2019

Abstract
To increase donations of nutritious food, Ontario introduced a tax credit for farmers who donate agricultural products to food banks in 2013. This research seeks to investigate the role of Ontario’s Food Donation Tax Credit for Farmers in addressing both food loss and waste (FLW) and food insecurity through a case study of fresh produce rescue in Windsor-Essex, Ontario. This research also documents the challenges associated with rescuing fresh produce from farms, as well as alternatives to donating. Interviews with food banks, producers and key informants revealed that perceptions of the tax credit, and the credit’s ability to address FLW and food insecurity, contrasted greatly with the initial perceptions of the policymakers who created the tax credit. In particular, the legislators did not anticipate the logistical challenges associated with incentivizing this type of donation, nor the limitations of a donation-based intervention to provide food insecure Ontarians with access to fresh, nutritious food.
Addressing Application Latency Requirements through Edge Scheduling
Authors: Aral Atakan , Brandic Ivona , Uriarte Rafael Brundo , De Nicola Rocco , Scoca Vincenzo 
Published: November 2019

Abstract
Latency-sensitive and data-intensive applications, such as IoT or mobile services, are leveraged by Edge computing, which extends the cloud ecosystem with distributed computational resources in proximity to data providers and consumers. This brings significant benefits in terms of lower latency and higher bandwidth. However, by definition, edge computing has limited resources with respect to cloud counterparts; thus, there exists a trade-off between proximity to users and resource utilization. Moreover, service availability is a significant concern at the edge of the network, where extensive support systems as in cloud data centers are not usually present. To overcome these limitations, we propose a score-based edge service scheduling algorithm that evaluates network, compute, and reliability capabilities of edge nodes. The algorithm outputs the maximum scoring mapping between resources and services with regard to four critical aspects of service quality. Our simulation-based experiments on live video streaming services demonstrate significant improvements in both network delay and service time. Moreover, we compare edge computing with cloud computing and content delivery networks within the context of latency-sensitive and data-intensive applications. The results suggest that our edge-based scheduling algorithm is a viable solution for high service quality and responsiveness in deploying such applications.
Optimization along families of periodic and quasiperiodic orbits in dynamical systems with delay
Authors: Ahsan Zaid , Dankowicz Harry , Sieber Jan 
Published: November 2019

Abstract
This paper generalizes a previously conceived, continuation-based optimization technique for scalar objective functions on constraint manifolds to cases of periodic and quasiperiodic solutions of delay-differential equations. A Lagrange formalism is used to construct adjoint conditions that are linear and homogenous in the unknown Lagrange multipliers. As a consequence, it is shown how critical points on the constraint manifold can be found through several stages of continuation along a sequence of connected one-dimensional manifolds of solutions to increasing subsets of the necessary optimality conditions. Due to the presence of delayed and advanced arguments in the original and adjoint differential equations, care must be taken to determine the degree of smoothness of the Lagrange multipliers with respect to time. Such considerations naturally lead to a formulation in terms of multi-segment boundary-value problems (BVPs), including the possibility that the number of segments may change, or that their order may permute, during continuation. The methodology is illustrated using the software package coco on periodic orbits of both linear and nonlinear delay-differential equations, keeping in mind that closed-form solutions are not typically available even in the linear case. Finally, we demonstrate optimization on a family of quasiperiodic invariant tori in an example unfolding of a Hopf bifurcation with delay and parametric forcing. The quasiperiodic case is a further original contribution to the literature on optimization constrained by partial differential BVPs.
Another Look at the Hartman-Watson Distributions
Authors: Jakubowski Jacek , Wiśniewolski Maciej 
Published: November 2019

Abstract
The article deals with the Hartman-Watson distributions and presents a new approach to them by investigating a special function u. The function u is strictly related to the distribution of the exponential functional of Brownian motion appearing in the mathematical finance framework. The study of the latter leads to new explicit representations for the function u. One of them is through a new parabolic PDE. Integral relations of convolution type between Hartman-Watson distributions and modified Bessel functions are presented. It turns out that u can be represented as an integral convolution of itself and the modified Bessel function K0. Finally, excursion theory and a subordinator connected to the hyperbolic cosine of Brownian motion are involved in order to obtain yet another representation for u. Possible applications of the resulting explicit formulas are discussed, among others Monte Carlo evaluations of u.
Key methodological considerations for usability testing of electronic patient-reported outcome (ePRO) systems
Authors: Aiyegbusi Olalekan Lee 
Published: November 2019

Abstract

Introduction
Recent advances in information technology and improved access to the internet have led to a rapid increase in the adoption and ownership of electronic devices such as touch screen smartphones and tablet computers. This has also led to a renewed interest in the field of digital health also referred to as telehealth or electronic health (eHealth). There is now a drive to collect these PROs electronically using ePRO systems.

Method
However, the user interfaces of ePRO systems need to be adequately assessed to ensure they are not only fit for purpose but also acceptable to patients who are the end users. Usability testing is a technique that involves the testing of systems, products or websites with participants drawn from the target population. Usability testing can assist ePRO developers in the evaluation of ePRO user interface. The complexity of ePRO systems; stage of development; metrics to measure; and the use of scenarios, moderators and appropriate sample sizes are key methodological issues to consider when planning usability tests.

Conclusion
The findings from usability testing may facilitate the improvement of ePRO systems making them more usable and acceptable to end users. This may in turn improve the adoption of ePRO systems post-implementation. This article highlights the key methodological issues to consider and address when planning usability testing of ePRO systems.
D-dimer testing, with gender-specific cutoff levels, is of value to assess the individual risk of venous thromboembolic recurrence in non-elderly patients of both genders: a post hoc analysis of the DULCIS study
Authors:   for the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators, Palareti Gualtiero , Legnani Cristina , Antonucci Emilia , Cosmi Benilde , Poli Daniela , Testa Sophie , Tosetto Alberto , Ageno Walter , Falanga Anna , Ferrini Piera Maria , Pengo Vittorio , Prandoni Paolo 
Published: November 2019

Abstract
Male patients, especially the young, are at a higher risk of recurrent venous thromboembolism (RVTE) than females. Recent scientific reports show the use of D-dimer does not help predict RVTE risk in males. In the present report, we reviewed the data obtained in the DULCIS study (main report published in Blood 2014), focusing on D-dimer results recorded in non-elderly patients of both genders included in the study, and their relationship with RVTE events occurring during follow-up. Using specifically designed cutoff values for positive/negative interpretation, serial D-dimer measurements (performed during warfarin treatment and up to 3 months after discontinuation of anticoagulation) in 475 patients (males 57.3%) aged ≤ 65 years were obtained. D-dimer resulted positive in 46.3% and 30.5% of males and females, respectively (p = 0.001). Following management procedure, anticoagulation was stopped in 53.7% of males and 69.5% of females, who had persistently negative D-dimer results. The rate of subsequent recurrent events was 1.7% (95% CI 0.5–4.5%) and 0.4% (95% CI 0–2.5%) patient-years in males and females, respectively, with upper limits of confidence intervals always below the level of risk considered acceptable by international scientific societies for stopping anticoagulation (< 5%). In conclusion, using sensitive quantitative assays with specifically designed cutoff values and serial measurements during and after discontinuation of anticoagulation, D-dimer testing is useful to predict the risk of RVTE and is of help in deciding the duration of anticoagulation in both male and female adult patients aged up to 65 years.
Die heterosexuelle Familie als Norm
Authors: Nay Yv E. 
Published: November 2019

ZusammenfassungDieser Beitrag thematisiert am Beispiel der Schweiz, wie im Rahmen der politischen Forderungen nach rechtlicher Anerkennung queerer Familien einerseits eine Erweiterung der rechtlichen Auffassung von Familie erfolgt, während gleichzeitig andererseits die heterosexuelle Familie als die Norm bestärkt wird. Er formuliert Überlegungen, was diese politischen Prozesse für die Arbeit von Kinder- und Jugendschutzbehörden bedeuten, die die rechtlichen Neuerungen rund um Regenbogenfamilien umsetzen müssen.
Unexpected intercalation-dominated potassium storage in WS2 as a potassium-ion battery anode
Authors: Wu Yuhan , Xu Yang , Li Yueliang , Lyu Pengbo , Wen Jin , Zhang Chenglin , Zhou Min , Fang Yaoguo , Zhao Huaping , Kaiser Ute , Lei Yong 
Published: November 2019

Abstract
Unexpected intercalation-dominated process is observed during K+ insertion in WS2 in a voltage range of 0.01–3.0 V. This is different from the previously reported two-dimensional (2D) transition metal dichalcogenides that undergo a conversion reaction in a low voltage range when used as anodes in potassium-ion batteries. Charge/discharge processes in the K and Na cells are studied in parallel to demonstrate the different ion storage mechanisms. The Na+ storage proceeds through intercalation and conversion reactions while the K+ storage is governed by an intercalation reaction. Owing to the reversible K+ intercalation in the van der Waals gaps, the WS2 anode exhibits a low decay rate of 0.07% per cycle, delivering a capacity of 103 mAh·g-1 after 100 cycles at 100 mA·g-1. It maintains 57% capacity at 800 mA·g-1 and shows stable cyclability up to 400 cycles at 500 mA·g-1. Kinetics study proves the facilitation of K+ transport is derived from the intercalation-dominated mechanism. Furthermore, the mechanism is verified by the density functional theory (DFT) calculations, showing that the progressive expansion of the interlayer space can account for the observed results.
The relevance of AMP-activated protein kinase in insulin-secreting β cells: a potential target for improving β cell function?
Authors: Szkudelski Tomasz , Szkudelska Katarzyna 
Published: November 2019

AbstractAMP-activated protein kinase (AMPK) is present in different kinds of metabolically active cells. AMPK is an important intracellular energy sensor and plays a relevant role in whole-body energy homeostasis. AMPK is activated, among others, in response to glucose deprivation, caloric restriction and increased physical activity. Upon activation, AMPK affects metabolic pathways leading to increased formation of ATP and simultaneously reducing ATP-consuming processes. AMPK is also expressed in pancreatic β cells and is largely regulated by glucose, which is the main physiological stimulator of insulin secretion. Results of in vitro studies clearly show that glucose-induced insulin release is associated with a concomitant inhibition of AMPK in β cells. However, pharmacological activation of AMPK significantly potentiates the insulin-secretory response of β cells to glucose and to some other stimuli. This effect is primarily due to increased intracellular calcium concentrations. AMPK is also involved in the regulation of gene expression and may protect β cells against glucolipotoxic conditions. It was shown that in pancreatic islets of humans with type 2 diabetes, AMPK is downregulated. Moreover, studies with animal models demonstrated impaired link between glucose and AMPK activity in pancreatic islet cells. These data suggest that AMPK may be a target for compounds improving the functionality of β cells. However, more studies are required to better elucidate the relevance of AMPK in the (patho)physiology of the insulin-secreting cells.
Habitat-specific effects of interstitial space between stream substrate particles on the colonization of aquatic organisms
Authors: Natsumeda Takaharu , Iguchi Kei’ichiro 
Published: November 2019

AbstractWe examined the effects of interstitial space between stream substrate particles on the colonization of aquatic organisms using three types of substrates (gravel, a cobble, and a cobble on gravel) in a riffle and pool of a temperate stream. Significantly greater abundance, wet weight, diversity (H′), taxonomic richness, and evenness of aquatic organisms were found in the riffle than in the pool, and the interstitial space substrate (i.e., a cobble on gravel) had significantly greater abundance, wet weight, and taxonomic richness of aquatic organisms than did the cobble substrate. Of the 13 families observed in the experiments, larval net-spinning caddisfly (Hydropsychidae) dominated the riffle in terms of the abundance and wet weight; chironomid larvae dominated both the riffle and the pool in terms of abundance. Simple main effect tests indicated significant effects of substrate on the abundance and wet weight of larval caddisfly in the riffle, and post hoc tests on substrate in each habitat indicated that the abundance and wet weight of larval caddisfly on interstitial space substrate were significantly greater than those on cobble substrate in the riffle. Our results suggest the importance of interstitial space between stream substrates in riffles to ensure higher colonization rates of aquatic organisms such as larval net-spinning caddisflies characterized as filter feeders.
Women fishers in Norway: few, but significant
Authors: Gerrard Siri , Kleiber Danika 
Published: November 2019

AbstractProfessional fishing and fisheries quota systems can affect women and men differently, yet gender analysis of quota systems is rare. In this article, we use a feminist framing and a mixed methods approach to examine the long-term gendered effects of the introduction of the 1990 quota system in Norway. Using statistics from the National Fishery Registry and the Directorate of Fisheries, we found that the number of women and men registered as fishers has declined since 1990 (an overall decline of 59%). Over this period, men have consistently outnumbered women among registered fishers (2.7–3.2% women), among boat owners (2.23% women in 2017) and particularly among owners of larger boats (> 11 m), which can have multiple quotas (0.35% women in 2017). However, changes in the age and geographic location among women fishers reflect changes to fisheries overall, as well as highlighting the gender-blind entry barriers that disproportionately impact women. In addition, contextualising statistical data with participant interviews conducted in North Norway, especially in Finnmark, enables us to examine more closely why the gender gap remains. This mixed method approach also identifies changes women and men working in fisheries have undergone, while also addressing women fishers’ political efforts to improve gender equity in Norwegian fisheries. Our study contributes to a more nuanced understanding of Norwegian coastal fishing, and particularly women’s small but significant presence.