bluuebunny/crossref_metadata_2025_split huggingface dataset:
La industria farmacéutica india en el capitalismo contemporáneo
Authors: Sosa Jesús 
Published: April 2020

<p>Este ensayo perfila la historia reciente de la industria farmacéutica en India. Para ello se contextualiza e identifica la ruta delineada por este sector, de vital importancia para sus pobladores y del mundo entero, y su actuación dentro de la economía mundial, que mueve a la industria local a convertirse en un actor internacional relevante.</p><p>El análisis aporta algunos elementos determinantes que definen el curso de la industria farmacéutica en esa región. El propósito no es discutir si su desempeño fue o no acertado, sino identificar las particularidades principales de actuación de este sector en la economía local y mundial. Se sostiene que la hipótesis que explica el relativo éxito en la etapa reciente es la conjunción de una serie de factores. Entre otros destacan, la adquisición de habilidades para la producción de fármacos de las empresas locales; regulación mediante el otorgamiento de patentes sobre procesos para la corporación local; en un entorno de competencia transnacional las empresas autóctonas utilizan deformulación o ingeniería inversa, para producir, a bajos precios y alta calidad, medicamentos genéricos altamente rentables.</p><div><div><p> </p></div></div>
Allelopathic effect of leaf extracts of Punica granatum and Spiraea prunifolia against post-harvest rot of tomato and brinjal
Authors: Koka Jahangir Abdullah , Bhat Mohd Yaqub , Wani Abdul Hamid 
Published: April 2020

Antimycotic activities of different solvent extracts of Punica granatum L. and Spiraea prunifolia Siebold and Zucc. were carried out through agar well diffusion assay at three concentrations (25µl, 50µl and 75µl) against seven fungi causing rot diseases of tomato and brinjal. All the concentration of plant extracts showed antifungal activity against tested pathogenic fungi. Antimycotic activity increased with the increased concentrations of plant extracts. However, higher concentrations proved more effective than lower concentrations. It was revealed from the present study that the ethanolic extract of Punica granatum L. showed maximum antifungal activity against Rhizoctonia solani and Penicillium expansum and least inhibitory activity against Aspergillus niger. However, the aqueous extract of Punica granatum L. showed maximum antimycotic activity against Rhizoctonia solani and Alternaria alternata and least inhibitory effect against Penicillium expansum. It was further observed from the present study that the ethanolic extract of Spiraea prunifolia Siebold and Zucc. showed maximum antimycotic activity against Rhizoctonia solani and least inhibitory effect against Alternaria alternata. Whereas the aqueous extract of Spiraea prunifolia Siebold and Zucc showed maximum antifungal activity against Aspergillus niger and least inhibitory activity against Alternaria alternata.
Keywords: Plant extracts, Concentration, Antimycotic effectiveness, tomato and brinjal, fungal rot pathogens, Inhibition zone.
The Assessment of Mucoadhesivity of Natural Polymer Derived Form Plant Sources
Authors: Samanta Radheshyam , Bhaumik Asish , Nayak Amit Kumar 
Published: April 2020

The main aim and objective of my present research work was to determine the various important mucoadhesive parameters such as mucoadhesive force, force of adhesion and bonding strength etc. Mucoadhesive properties of natural polymers were evaluated by formulating gels using Carbopol 940 P as a gelling agent. Mucoadhesive parameters of the prepared Carbopol 940 P gels containing natural polymers were determined by ex vivo followed by modified physical balance using excised cock intestinal mucosa. From the recent experimental data it was displayed that the mucoadhesive strength, force of adhesion and bonding strength of gel containing low methoxy pectin (1 % w/v) was found higher than other tested gels. The gel containing Moringa oleifera gum (1 % w/v) exhibited less mucoadhesion than other tested gels. The order of mucoadhesion of these plant-derived polymers was found as: low methoxy pectin > jackfruit seed starch > cashew gum/okra gum gum > pumpkin pectin > linseed mucilage > sago starch > gum Arabic > xanthan gum > fenugreek seed mucilage/black palm seed polysaccharide > Moringa oleifera gum.
Keywords: Mucoadhesion, Mucoadhesive strength, gelling agent, intestinal mucosa, and plant derived polymers etc.
Formulation and In-Vitro Evaluation of Enteric Coated Tablet Incorporating Rabeprazole
Authors: Mehetre Gautam D. , Cheke Rameshwar S. , Shrikhande Vinayak N. 
Published: April 2020

The objective of the work is to try and assess the applicability and manufacturing possibilities to optimize an enteric coated tablet formulation containing Rabeprazole sodium as the drug aiming at the anti-acidity activity with desired drug release properties. Enteric coated tablet was chosen as dosage form being a cost-effective technology for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technological aims, analysis of critical factors influencing the manufacture was carried out. Reproducible manufacturing processes are required to achieve suitability and tablets uniformity to achieve the uniform properties of tablets, which could influence experimental parameters. Rabeprazole in core content of tablet is blended with HPMC (different grades), xanthan gum, PVPK30, mannitol, crosspovidone, Sodium starch glycolate, Colloidal silicon dioxide to formulate the product. Prepared formulation was tested for weight and content uniformity, physical characteristics, in vitro dissolution behaviour, acid resistance and accelerated stability studies. All studies performed resulted and revealed for assurance of such enteric coated tablet formulation for drug Rabeprazole with optimum characteristics, concluding it as a promising approach to enhance drug release characteristics.
Keywords: Rabeprazole, HPMC, enteric coated tablets, In Vitro evaluation.
How JRK’s 777 oil demolishes the dense, viscous herbal rich oils can be ineffective for psoriasis
Authors: Aruna V , Amruthavalli GV , Soundharya R , Gayathri R 
Published: April 2020

The present study deals with the importance of herbal particle size in the AYUSH oil preparations for psoriasis in order to achieve greater absorption and therapeutic value. More often the viscosity of the oil, deep colour and the density of herbal constituents are associated with superior therapeutic value. But our study has clearly demonstrated that the dermal absorbable herbal constituents (under 40 µm) was less than 10% in most of the Wrightia tinctoria based AYUSH oil preparations sold for the treatment of psoriasis in India whereas Dr. JRK’s 777 oil contain more than 60% of the herbal constituents below 40 µm size. Further the role of particle size besides dermal absorption; in the therapeutic value also established by oxygen species scavenging assay. Findings reveal that smaller the particles greater was the antioxidant effect and hence such herbal constituents not only would offer superior therapeutic effect but also protection to the oil from going rancid. Details are presented in the paper.
Keywords: AYUSH oils, Herbal oil, Psoriasis, dermal absorption, Wrightia tinctoria, rancid oil
Evaluation of the Effect of Hydroalcoholic Extracts of Cassia Occidentalis Leaves in Neutrophil Adhesion Test in Rats
Authors: Patel Dhaval M , Patel Advaita B , Trivedi Riddhi D , Parmar Viram J , Bangoriya Urvisha V 
Published: April 2020

Evaluation of the effect of hydroalcoholic extracts of Cassia occidentalis leaves in neutrophil adhesion test in Rats. The effect of oral administration of hydroalcoholic extract of Cassia occidentalis leaves on neutrophil has been studied and is compared with control group on rats. The differential leukocyte count (DLC) was performed by fixing the blood smears and staining with leucofine and percent neutrophils in each sample was determined. After the initial counts, blood samples were incubated with 80 mg/ml of nylon fibers for 10 min at 37ºC. Supplementation with hydroalcoholic extract of Cassia occidentalis leaves significantly decreased neutrophil adhesion. The results indicate that the leaf of Cassia occidentalis is endowed with protected neutrophil adhesion. These effects could conclude that Cassia occidentalis has an antiasthmatic property.
Keywords: Cassia occidentalis, Neutrophil adhesion, analysis of variance
A Comprehensive Review on Plant derived Natural products for Diabetes and its complication as nephropathyA study to assess the effectiveness of informative booklet regarding knowledge of breast cancer and breast self-examination among the 2nd year B.Sc nu
Authors: Mansuri Mustufa U. , Mansuri Farzana 
Published: April 2020

Background: Breast cancer is the most common type of cancer in women and the second leading cause of cancer related death, next the lung cancer. If eight women live to the age of 85 year at list one of them will develop breast cancer in her life time. Two thirds of women diagnosed with breast cancer are over the age of 50 year. It is estimated that only 25%-30% of women perform breast self examination proficiently and regularly each month. Breast cancer is a common cause of cancer morbidity and mortality in women.
Aims and objective: To assess the knowledge of 2nd year B.sc nursing students in Government College of nursing, Siddhpur. To determine the effectiveness of informative booklet among 2nd year b.sc nursing students in government college of nursing, Siddhpur. To find association between pre-test knowledge and post-test knowledge.
Material and Methods: In the present study the investigator selected quasi-experimental research approach, single group pre-test and post-test design was used.35 students of 2nd year B.Sc. Nursing students of government college of Nursing, Siddhpur(Gujarat) selected by using purposive sampling technique. A structured questionnaire was used.
Results: findings revealed that highest percentages (82.86%) were in the age group of 19- 20 year, and (11.43%) of them were in the age group of 20-21 years, (94.28%) were in the religions of Hindu and (2.86%) in the religions of Muslim and Christian. (100%) were had Higher Secondary education. (91.43%) were taking Vegetarian Diet and (8.57%) were taking mixed diet. (62.86%) are from Joint Family and (37.14%) are from Nuclear Family. Study findings revealed that The knowledge score of the sample show marked increase as seen in the post-test score of the experimental group, which indicate that the informative booklet is effective in increasing the knowledge of the sample regarding breast cancer and breast self examination.
Keywords: Study, Assess, Effectiveness, Informative, Adolescent Girl, Knowledge, Breast Cancer, Breast Self Examination.
Development and Validation of Spectrophotometric Method for the Estimation of Enoxaparin sodium in marketed formulation
Authors: Sahu Sandeep , Lariya Narendra Kumar 
Published: April 2020

Simple, cost effective, precise and accurate UV-Spectrophotometric method for estimation of Enoxaparin sodium was developed and validated as per ICH guidelines. This Method involves solving of calibration curve based on measurement of absorbance wavelengths 234nm in 0.1 N HCl. The method obeys the Beer’s law in the concentration ranges 100-500µg/ml. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. % Recovery for both the drugs were in the range of 99.288 99.632% indicating excellent accuracy with percentage RSD Values less than 2. The method was precise, with a relative standard deviation of less than 2% for all tha validation parameters. Thus, method can be used for routine monitoring of drugs in industry for the assay of bulk drugs and commercials.
Keywords: UV-Spectrophotometric, Enoxaparin sodium, Validation, ICH guidelines
Comparación agronómica entre tipos de pepino (Cucumis sativus)
Authors: Cruz-Coronado Jose Aníbal , Monge-Pérez José Eladio , Loría-Coto Michelle 
Published: April 2020

Introducción: El pepino es un cultivo hortícola importante en Costa Rica. Objetivo: El objetivo del estudio fue evaluar el rendimiento y la calidad de tres tipos de pepino (largo, mediano y pequeño), cultivados bajo invernadero en condiciones hidropónicas en la Estación Experimental Agrícola Fabio Baudrit Moreno, en Alajuela, Costa Rica. Métodos: El cultivo se manejó con fertirrigación, en sustrato de fibra de coco, y con poda a un tallo por planta. Resultados: El pepino pequeño inició cosecha a los 26 días después del trasplante (ddt), mientras que los tipos mediano y largo lo hicieron entre los 28 y 30 ddt. Los datos muestran una amplia variabilidad entre los tipos de pepino en cuanto a: longitud (11,89 – 31,74 cm), diámetro (43,15 – 50,37 mm) y peso del fruto (143,07 – 488,19 g); número de frutos (22,81 – 90,14) y rendimiento por planta (8656,32 – 12911,67 g); rendimiento por área (22,48 – 33,54 kg/m2); y porcentaje de sólidos solubles totales (3,03 – 3,22 °Brix). El mayor número total de frutos por planta (90,14) se obtuvo con el pepino pequeño, mientras que el menor número total de frutos por planta (22,81) y los frutos con el mayor peso (488,19 g) se obtuvieron con el pepino largo. El mayor rendimiento total (33,54 kg/m2), comercial (27,10 kg/m2) y de primera calidad (16,41 kg/m2) se obtuvo con el pepino pequeño. Conclusiones: Desde un punto de vista económico, se considera que el pepino pequeño es el más recomendable bajo las condiciones en que se desarrolló el ensayo, aunque está pendiente de evaluación su aceptación por parte del consumidor en Costa Rica.
PENGARUH SUBSTITUSI GONDORUKEM PADA ASPAL PENETRASI 60/70 DENGAN MENGGUNAKAN AGREGAT HALUS SABANG TERHADAP STABILITAS MARSHALL
Authors: Azka Cut Nawalul , M. Saleh Sofyan , Sugiarto Sugiarto 
Published: April 2020

Basically, aggregate is the one of pavement capacity. The determining of fine aggregate Sabang has low quality because the value absorption is 4.45% greater than 3%. The purpose of this research is to identify the effect of gum rosin substitution on asphalt penetration 60/70 with fine aggregate sabang for Marshall characteristics.The trial method is Marshall method by using dry process. Based on the research results the value of optimum bitumen is 5.87%. from the research result it can be concluded that if the greater value of aggregate then the weight from those type of aggregate is smaller so the weight of the type of maximum mixture become small, whereas the smaller value of aggregate porosity then the weight of the type from those aggregate is larger so that the weight of the maximum type mixture became much larger. The percentage aggregate variation (AHS 50%:AHI 50%), (AHS 75%:AHI 25%), and (AHS 100%:AHI 0%). The results showed the value stability is lower, when percentage of fine aggregate sabang more excessively. The best value stability is 50% of fine aggregate sabang and 50% and aggregate from Aceh Besar. The utilizing of value percent fine aggregate sabang that excess is poor in quality, because binding strength not efectif. One way anova show the value of density, VIM, VMA, VFA, Stability Flow and Marshall shows is F count is larger than the value F table and the value of sig. smaller than the value of , it’s means Ho is rejected and Ha is accepted, meaning is influential.
ANALISA SKALA PRIORITAS PROYEK PEMBANGUNAN JALAN DI KABUPATEN ACEH JAYA
Authors: Fuadi Rahmad , Isya Muhammad , Anggraini Renni 
Published: April 2020

The limited funding of the Aceh Jaya regency government for development, including the construction of road infrastructure and the way in which road construction projects are still inaccurate and the process of budgeting unproportional work package by the Aceh Jaya regency government itself has not been able to fully meet the needs of road development in Aceh Jaya. Therefore, the need for priority scale that can be used as the basis of consideration in the process of development of road infrastructure development program. The purpose of this study is to determine the priority order of several road infrastructure development projects in Aceh Jaya regency by selecting or considering the appropriate criteria and according to development condition in Aceh Jaya regency using Multi Criteria Analysis (MCA) method. The weight of each criterion was calculated based on an assessment of the importance between the criteria obtained by interviewing stakeholders in Aceh Jaya regency government, while the alternative road performance score was obtained by analyzing and calculating the scale of the assessment quantitatively against each criterion based on secondary data obtained from related offices. Selected criteria are accessibility, environmental aspect, area development aspect, social aspect and development cost. Social aspect criteria get the highest weight of 0.279, it can be interpreted that social aspect is the main consideration in determining priority of road development in Aceh Jaya regency, because social aspect see influence of economic growth and social welfare of society from development of road infrastructure. Based on the consideration of these criteria, the order of priority scale of road construction project in Aceh Jaya regency, where road in Calang city, Krueng Sabee sub-district is the first priority with score value 6,72.
PENGARUH PENGGUNAAN AGREGAT HALUS JAMUR UJUNG PADA CAMPURAN LASTON AC-WC
Authors: Fahmi Ardian , M. Saleh Sofyan , Isya Muhammad 
Published: April 2020

The good quality of road surface layers are strongly influenced by the materials used such as the aggregate composition, asphalt, and filler. Fine Aggregate from Jamur Ujung is a local aggregate that can be found in Bener Meriah District. It has not been utilized maximally due to its porosity and high aggregate absorption. This research is conducted to see improvement of the characteristics that can be done to the asphalt mixture using the fine aggregate from Jamur Ujung. It is expected that this aggregate is feasible to be used as an asphalt mixture material in accordance to the specifications set by Bina Marga. This research was conducted by producing test objects (specimen) to determine the optimum asphalt content using standard aggregate from Lepung Baleuh, Kuta Cot Glie, Aceh Besar District, then the test object with combination of standard fine aggregate mixture with fine aggregate of Jamur Ujung with the variation percentage respectively by 25%, 50%, 75% and 100% at 5.35%, 5.87% and 6.35% asphalt content in the mixture of AC-WC. The results of this study show the mixture that meets specifications that represent all Marshall characteristics is a mixture with substitution of 50% fine aggregate of Jamur Ujung at 5.87% asphalt content with a stability value of 1355.90 Kg. Results of this research also show that fine aggregate of Jamur Ujung can be used as road construction project especially for asphalt concrete work (AC-WC).
ANALISIS PERKERASAN LENTUR DI ATAS TANAH EKSPANSIF
Authors: Mukhlis Mukhlis , Yunus Yuhanis , M. Saleh Sofyan 
Published: April 2020

The segmented road of Bireuen-Takengon has often damaged in apart of its pavement structure due to the area of flexible pavement structure taken place upon an expansive soil that leads to depreciation caused by the influence of changes in the water level. The aim of this research method was to analyze the characteristics of the base soil underlying the pavement and to analyze the flexible pavement structure in the widening of the road. The observed area was Sta.70+175 s/d Sta.74+925 which taken place in Bener Meriah regency, sub-district of Timang Gajah. The results of USCS clarification show that the road of basal soil is included in the MH and OH with a PI value of 25.42%, LL 64.25% with a potential level of development and activity belonging to the medium-high category and also having mineral types of Illite. From the analysis of KENPAVE software, the design of flexible pavement structures is based on data planning that has a maximum stress and deflection value, on the base soil, of 0.1814 kg/cm2 and 0.0585 cm respectively. Moreover, based on Job mix data the maximum value of stress and deflection is 0.2444 kg/cm2 and 0.0585 cm respectively in which both of two stress and deflections are within the allowable limit; which both of two stress and deflections are within the allowable limit; 7.8 kg/cm2 and 2.5 cm. The evaluation results of both data are feasible to be used as an improved design on the pavement as the pressure generated by the weight of the road pavement structure is 1.949 kg/cm2, while the swell pressure that occurs on subgrade is 1.805 kg/cm2. Hence, The flexible pavement structure on the road segment is still able to reduce the swell potential on expansive soil.
PENGARUH MANUVER KENDARAAN PARKIR DI BADAN JALAN TERHADAP DERAJAT KEJENUHAN PADA JALAN TEUKU UMAR KOTA BANDA ACEH
Authors: Yusmadi Yusmadi , Sugiarto Sugiarto , Anggraini Renni 
Published: April 2020

Teuku Umar Street has very high activities as an access service, but there are also on-street parking facilities. On-street parking facilities cause traffic congestion on teuku umar road area, especially in public service areas such as Seutui Market, Harapan Bunda Hospital, Suzuya Mall and Canai Mamak. This is caused by the influence of vehicle maneuvers when entering and exiting from parking facility location, and this phenomenon often occurs during rush hour and the volume of vehicles is very dense. Based on these problems, a study was conducted to determine the effect of vehicle maneuvers when exiting and entering of parking facility on the traffic of degree of saturation and relation model between volume, speed and density using 3 models i.e. Greenshields, Greenberg and Underwood. Based on the analysis results, the Greenberg Model is the best model with the highest determination of the three variables of speed-density-volume. The model is chosen based on the greatest value of determination approaching one rate. The capacity of Teuku Umar Street Directions Gunongan-Sp.Tiga is 2970 pcu/hour, and after the on-street parking activity, the capacity decreased by 2079 pcu/hour (30%). For the way to Gunongan, the capacity is 2970 pcu/hour, after parking activities the capacity drops 2524 pcu/hour (15%). The value of saturation degree in the segment is no parking facility towards Gunongan to Sp. Tiga is 0.31 and there is parking obtained 0.43. Sp. Tiga-Gunongan street direction has the value of surfeit level on the segment no parking facility at 0.37 and there is parking obtained at 0.44. The alternative improvements to increase capacity is by providing special parking facilities and limiting vehicles in and out, so that the surfeit level will decrease.
ANALISIS PERMODELAN SUB DAS PADA DAERAH ALIRAN SUNGAI KRUENG PASE KABUPATEN ACEH UTARA
Authors: Rahmawati Rahmawati , Fatimah Eldina , Masimin Masimin 
Published: April 2020

Watershed management can be started by evaluation how the response of watershed hydraulic toward rainfall and become run off that will flow downstream. Transformation of rain into flow is a method used to find out effect of land use change and its parameter toward flow hydrograph. Watershed Kr. Pase is one of most rapid reduction of forest area. Land use change occurred in this watershed affecting discharge amount of run off which required further calculation. This calculation using the rational method by calculating rainfall intensity parameter (I),watershed area (A), and flow coefficient (C) in watershed. Data of land use provide in this study are on year 2007, 2013, and 2017 which will examine watershed Kr. Pase into subwatershed model, whereas from map analysis obtained three subwatersheds. After some calculation off run off discharge at watershed Kr. Pase, than it is use sub-watershed with longest concertration time (tc).