bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal snow cover indicators in coastal Greenland from in situ observations, a climate model, and reanalysis
Authors: van der Schot Jorrit , Abermann Jakob , Silva Tiago , Rasmussen Kerstin , Winkler Michael , Langley Kirsty , Schöner Wolfgang 
Published: December 2024

Abstract. Seasonal snow cover has important climatic and ecological implications for the ice-free regions of coastal Greenland. Here we present, for the first time, a dataset of quality-controlled snow depth measurements from nine locations in coastal Greenland with varying periods between 1997 and 2021. Using a simple modelling approach (Δsnow), we estimate snow water equivalent values solely based on the daily time series of snow depth. Snow pit measurements from two locations enable us to evaluate the Δsnow model. As there are very little in situ data available for Greenland, we then test the performance of the regional atmospheric climate model (RACMO2.3p2, 5.5 km spatial resolution) and reanalysis product (CARRA, 2.5 km spatial resolution) at the nine locations with snow observations. Using the combined information from all three data sources, we study spatio-temporal characteristics of the seasonal snow cover in coastal Greenland using the example of six ecologically relevant snow indicators (maximum snow water equivalent, melt onset, melt duration, snow cover duration, snow cover onset, and snow cover end date). In particular, we evaluate the ability of RACMO2.3p2 and CARRA to simulate these snow indicators at the nine different locations, perform a time series analysis of the indicators, and assess their spatial variability. The different locations have considerable spatial and temporal variability in snow cover characteristics, and seasonal maximum snow water equivalent (amount of liquid water stored in the snowpack) values range from less than 50 kg m−2 to greater than 600 kg m−2. The correlation coefficients between maximum snow water equivalent output from Δsnow and CARRA and RACMO are 0.73 and 0.48, respectively. Correlation coefficients are highest for maximum snow water equivalent and snow cover duration, and model and reanalysis output underestimate snow cover onset. We find little evidence of statistically significant (p<0.05) trends at varied periods between 1997 and 2021 except for the earlier onset of snowmelt in Zackenberg (−8 d per decade, p=0.02, based upon RACMO output). While we stress the need for context-specific validation, this study suggests that in most cases snow depth or snow water equivalent output from CARRA can describe spatial and temporal characteristics of seasonal snow cover, particularly changes in melt onset and snow cover end date.
Integrating the Relationship Between Exponents of the Utility Function and the Proportion of the Substitution and Income Effects of the Slutsky Equation into the Microeconomics Literature
Authors: Azim Parvez , Gondal Shabbir Ahmad , Amin Azka 
Published: December 2024

The primary purpose of this paper is to explore the relationship between exponents of a linearly homogeneous (Cobb-Douglass type ) utility function and magnitude of the substitution effect (SE) and income effect (IE) in both the Slutsky and Hicks approaches. It is explored that when the price of a good with a larger exponent in the utility function increases the income effect is greater than the substitution effect, and the converse holds when the price of a good with a relatively smaller exponent increase. When exponents of both goods in the utility function are of the same magnitude, the income and substitution effects are equal irrespective of whether the price of the good or good changes. This concept has not been explored before and thus, it should be included in Microeconomics literature. It has also been shown that for a given utility function the ratios of the utility elasticities of the goods equal the ratio of the income and substitution effects. Also, the Marshallian demand curve is more price elastic than the Slutsky demand curve which is more elastic than the Hicks demand curve.
sistema Tukuypaq. Aportes de la medicina tradicional para el abordaje integral de epidemias o pandemias
Authors: Peredo Albornoz Gabriel , Prado Mendoza Carlos 
Published: December 2024

La Estrategia de Medicina Tradicional de la Organización Mundial de la Salud busca apoyar a los estados en el desarrollo de políticas, iniciativas y planes de acción que fortalezcan el rol de la medicina tradicional y complementaria en la cobertura universal de salud, objetivo común que se traza en el llamado de la comunidad internacional por generar mecanismos de prevención ante eventuales pandemias o epidemias. Este tipo de estrategias conlleva retos y fronteras que plantean la exploración de enfoques integrales como One Health para el estudio de los vínculos materia-información-energía, mente-cuerpo-espíritu o comunidad humana-natural-sagrada, relaciones indispensables para comprender el proceso de salud-enfermedad desde la óptica compleja de la red de vida. En este marco, este trabajo ofrece una aproximación a la aplicación del Sistema Tukuypaq de armonización físico-espiritual, basada en el manejo integral de plantas maestras y prácticas rituales de diferentes culturas y tiempos, desde un abordaje transdisciplinario. De esta manera se evidencia las potencialidades de las sabidurías ancestrales para el campo de la medicina de la conservación respecto a la importancia de la adaptación-complementación-traslación de los principios que orientan el curanderismo con las prácticas médicas actuales ante eventuales pandemias o epidemias.
Denosumab combined with immunotherapy, radiotherapy, and granulocyte-macrophage colony-stimulating factor for the treatment of metastatic nasopharyngeal carcinoma: A case report
Authors: Chen Wei-Wu , Kong Yue-Hong , Zhang Li-Yuan 
Published: December 2024

BACKGROUND
Bone is a major site of metastasis in nasopharyngeal carcinoma (NPC). Recently, nuclear factor kappa-beta ligand (RANKL) inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption, as well as their potential to modulate immune functions and thereby enhance the efficacy of programmed cell death protein 1 (PD-1) inhibitor therapy.
CASE SUMMARY
We present a case of a patient with NPC who developed sternal stalk metastasis and multiple bone metastases with soft tissue invasion following radical chemoradiotherapy and targeted therapy. Prior to chemotherapy, the patient experienced severe bone marrow suppression and opted out of further chemotherapy sessions. However, the patient received combination therapy, including RANKL inhibitors (denosumab) alongside PD-1, radiotherapy, and granulocyte-macrophage colony-stimulating factor (PRaG) therapy (NCT05435768), and achieved 16 months of progression-free survival and more than 35 months of overall survival, without encountering any grade 2 or higher treatment-related adverse events.
CONCLUSION
Denosumab combined with PRaG therapy could be a new therapeutic approach for the second-line treatment in patients with bone metastases.
Individualized treatment guided by endoscopic ultrasound-guided fine-needle aspiration for adrenocortical oncocytoma: A case report
Authors: Chen Han , Jing Xue 
Published: December 2024

BACKGROUND
Adrenocortical oncocytoma is a rare, mostly benign, nonfunctional tumor that is typically detected incidentally. Its diagnosis is challenging because of the absence of distinctive imaging characteristics, necessitating pathological validation.
CASE SUMMARY
We present a case report of a 35-year-old woman with an adrenal mass located on the left side, where endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) was performed after comprehensive diagnostic assessment. Our results are consistent with those of previously documented cases regarding tumor demographics and anatomical location. Given the limited number of reports on this condition, long-term follow-up is crucial to enhance our understanding of its prognosis.
CONCLUSION
For patients with adrenocortical oncocytoma, EUS-FNA can enables collection of preoperative tissue specimens leading to suitable treatment strategies.
Mapping the landscape of gastric signet ring cell carcinoma: Overcoming hurdles and charting new paths for advancement
Authors: Wang Shu-Yuan , Wang Jing-Hang , Chen Run-Kai , Yuan Zhen , Cui Hao , Wei Bo , Cui Jian-Xin 
Published: December 2024

BACKGROUND
In recent years, the global prevalence of gastric cancer (GC) has witnessed a progressive decrease, accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma (GSRCC). As precision medicine concepts progress, GSRCC, a distinct sub-type of GC, has drawn considerable attention from researchers. However, there still persist some controversies regarding the associated research findings.
AIM
To summarize the current obstacles and potential future directions for research on GSRCC.
METHODS
To begin with, all literature related to GSRCC published from January 1, 2004 to December 31, 2023 was subjected to bibliometric analysis in this article. Additionally, this paper analyzed the research data using CiteSpace, GraphPad Prism v8.0.2, and VOSviewer, which was obtained from the Web of Science Core Collection database. The analysis results were visually represented.
RESULTS
This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC, including cited references, authors, journals, countries, institutions, and keywords. The popular keywords and clusters contain "prognosis", "survival", "expression", "histology", and "chemotherapy".
CONCLUSION
The prognosis, precise definition and classification, as well as chemoresistance of GSRCC, continue to be crucial areas of ongoing research, whose directions are closely tied to advancements in molecular biology research on GSRCC.
Overexpression pattern, function, and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma
Authors: Zhou Sheng-Sheng , Ye Yu-Ping , Chen Yi , Zeng Da-Tong , Zheng Guang-Cai , He Rong-Quan , Chi Bang-Teng , Wang Lei , Lin Qian , Su Qin-Yan , Dang Yi-Wu , Chen Gang , Wei Jia-Liang 
Published: December 2024

BACKGROUND
In recent years, many studies have shown that proteasome 26S subunit non-ATPase 6 (PSMD6) plays an important role in the occurrence and development of malignant tumours. Unfortunately, there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma (HCC).
AIM
To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC tissues.
METHODS
This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues, along with immunohistochemical scores from 383 HCC and adjacent tissues, to assess PSMD6 overexpression in HCC. Clustered regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell growth. Functional enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in HCC. Drug sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC cells.
RESULTS
The results of 41 external and two internal datasets showed that PSMD6 mRNA (SMD = 0.26, 95%CI: 0.09-0.42, P < 0.05) and protein (SMD = 2.85, 95%CI: 1.19-4.50, P < 0.05) were significantly overexpressed in HCC tissues. The integrated analysis results showed that PSMD6 had a significant overexpression pattern in HCC tissues (SMD = 0.40, 95%CI: 0.15-0.66, P < 0.05). PSMD6 knockout inhibited HCC cell growth (chronos scores < -1). Functional enrichment implicated ribosome biogenesis and RNA splicing. Significant enrichment of signalling pathways such as RNA degradation, ribosomes, and chemical carcinogenesis—reactive oxygen species. Drug sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323, sepantronium bromide, and GDC0810. Overexpressed PSMD6 effectively distinguished HCC tissues (AUC = 0.75, 95%CI: 0.71-0.79).
CONCLUSION
This study was the first to discover that PSMD6 was overexpressed in HCC tissues. PSMD6 is essential for the growth of HCC cells and may be involved in ribosome biogenesis and RNA splicing.
PERANCANGAN BUSANA READY-TO-WEAR DENGAN INSPIRASI ARSITEKTUR SUKIYA-ZUKURI MENGGUNAKAN TEKNIK INTERLOCKING MODULAR
Authors: Kuswinarti Kuswinarti , Rohmah Siti , Elriska Ripelian 
Published: December 2024

Pembuatan busana ready-to-wear dengan inspirasi dari gaya arsitektur sukiya-zukuri dapat diterapkan dengan menggunakan teknik interlocking modular. Teknik interlocking modular merupakan teknik penggabungan modul-modul kecil dengan melakukan pengulangan tanpa perekatan ataupun penjahitan. Teknik ini memiliki keunikan pada proses penggabungan modul-modul melalui mekanisme kuncian. Teknik interlocking modular menjadi salah satu teknik alternatif yang dapat digunakan pada bidang fesyen sehingga menampilkan desain permukaan dan kenampakan yang berbeda pada busana. Metodologi penelitian yang digunakan adalah studi pustaka, observasi, eksploratif dan pembuatan produk. Hasil produk dari penelitian ini berupa busana ready-to-wear yang terinspirasi arsitektur sukiya-zukuri dengan teknik interlocking modular untuk mendapatkan kenampakan yang berbeda melalui efek kuncian pada modul sehingga meningkatkan nilai estetika busana saat digunakan pada kegiatan sehari-hari ataupun menghadiri acara dengan tema khusus lainnya. Jenis kain yang digunakan pada reka bahan interlocking modular mempengaruhi kekuatan sambungan interlock pada modul. Jenis kain yang sesuai untuk reka bahan interlocking modular adalah kain dengan serat poliester–kapas yang memiliki kontruksi kain tenun anyaman polos dan penyempurnaan sueding dengan nama dagang kain suede.
Pemanfaatan Teknologi Blockchain untuk Meningkatkan Efisiensi dan Efektivitas Sistem Perpajakan: Tinjauan Literatur Sistematik
Authors: Hindayani Novia 
Published: December 2024

This study aims to determine how the factors that influence the successful implementation of blockchain in the tax system through a literature review of 14 samples of international journal articles from 2019-2024. The results of the study show that most publications increase in 2024, namely 4 articles. China and Indonesian is the most researched country. The factors that influence the successful implementation of blockchain in tax system are divided into 5 factors, namely belief & trust, government policy, infrastructure, human resource capabilities and ease of use. This research contributes to the development of knowledge about blockchain in tax systems worldwide. Researchers can investigate empirically the factors identified as confirmation of research, and further researchers can also expand their research area using other models. The findings are obtained from the review literature, so more in-depth testing is needed through the interview or questionnaire method.
Measuring the ‘between’ with team assessment: Going beyond an individual lens
Authors: Williams Corinne 
Published: December 2024

Key digested message

As assessments in organisations have historically mostly focused on the individual, the critical influence of team dynamics on organisational performance has been overlooked. A team, distinct from a group, achieves success through interdependent efforts towards a shared purpose. This makes trust, psychological safety, inclusion, and shared competence vital for high performance.
Assessing team level drivers of performance factors can pinpoint improvement areas and deliver higher commitment, motivation and positive organisation impact. One assessment specifically designed to do this is the Team Alignment Assessment (embedded in Produgie). A case study of a fintech leadership team demonstrates the effectiveness of this approach. This underscores the importance of integrating both individual and team-level assessments to foster personal and organisational success, ultimately enhancing overall performance.
Analysis of Monopoly Practices and Business Competition in the Limboto Traditional Market
Authors: Mardiana Andi , Jerita Nurlian , Pakaya Delviranti , Rahim Ziamudin G , Abay Rizky Firmansyah 
Published: December 2024

This study analyzes the practices of monopoly and business competition in the traditional market of Limboto, Gorontalo. The Limboto traditional market is a significant trade center in the region, involving various types of goods and services. The study aims to explore how monopoly practices and competition dynamics affect market conditions, commodity prices, and the welfare of both traders and consumers. The research methods include direct observation, interviews with market participants, and secondary data analysis. The findings indicate the presence of monopoly practices by several major traders that impact the prices and accessibility of goods in the market. Additionally, business competition in the Limboto traditional market exhibits unique characteristics, including informal collaboration among traders and the role and influence of the local market on competition. This research is expected to provide insights for policymakers and stakeholders in formulating strategies to enhance market efficiency and local economic welfare.

Keywords : Monopoly, Business Competition, Traditional Market
PEMBERIAN PERINTAH KERJA DALAM MASA CUTI BAGI PEKERJA, WAJIBKAH?
Authors: Sitohang Mawar 
Published: December 2024

One of the fundamental rights of workers/laborers at work is the right to leave which is granted by law, and its implementation needs to be guaranteed in the employment relationship between workers/laborers and employers. Workers taking leave means that workers are given the opportunity to take time off from work. However, it is not uncommon for employers to still ask workers to do work while on leave. This is a problem for workers, whether they should do their work or not? If work orders from superiors are not carried out, the consequences can be detrimental to workers. So how are workers' leave rights regulated according to labor law, and what steps must workers take if they receive a work order while on leave? This research will examine this problem using normative research that examines secondary data using a statutory approach. Based on the results of the research, it was found that work orders to employees while on leave constitute a violation of the work agreement and are detrimental to the worker so that it is an act of breaking the employer's promise to the worker.
A evolução na forma de disseminação das informações sobre HIV/AIDS entre adolescentes e jovens: uma revisão de escopo
Authors: Brito Vanessa Carla do Nascimento Gomes , Maximiano Luzia Cibele de Souza , Andrade Fernanda Belmiro de , Abrantes Rogéria Moreira de , Rojas Yenifer Lizeth Gañan , Costa Elanna Nayele de Freitas , Andrade Raíssa Martins de , Feijão Alexsandra Rodrigues 
Published: December 2024

A adolescência é uma fase caracterizada por mudanças biopsicossociais, e por ser um período de maior vulnerabilidade, especialmente em relação a exposição às infecções sexualmente transmissíveis, como a aids, cuja a prevenção exige educação em saúde efetiva e direcionada ao público jovem, a qual se dá mediante diversas formas de disseminação de informações, tais maneiras acompanharam as mudanças da revolução industrial. Assim, o objetivo do estudo é mapear na literatura a evolução na forma de disseminação das informações sobre HIV/Aids entre adolescentes e jovens. Trata-se de uma revisão de escopo, em que a coleta de dados se deu no mês de maio a junho de 2024 em três bases eletrônicas. O levantamento bibliográfico resultou em 29 estudos que compuseram a amostra final. Em sua maioria dos anos de 2010 - 2019, sendo possível categorizar três principais formas de transmissão de informações, a saber: os meios audiovisuais, escritos e interpessoais. Dessa forma, conclui-se que, embora a televisão e os canais interpessoais, como familiares e círculos de amizade, continuem sendo as fontes predominantes, as plataformas digitais estão se destacando como recursos influentes, alinhando-se ao progresso tecnológico e aos hábitos das novas gerações.
Uso de óleos essenciais no alívio dos sintomas da dismenorreia
Authors: Santos Crislaine Bispo dos , Machado Marina Ferreira , Santos Antenor Aguiar , Santos Renata Cristina Schmidt 
Published: December 2024

Dismenorreia é a dor pélvica que surge no primeiro dia do período menstrual, acomete muitas mulheres e pode afetar suas relações interpessoais, sua esfera social e até mesmo interferir em seu estilo de vida. As Práticas Integrativas e Complementares (PIC) podem colaborar para o alívio da dismenorreia primária. Verificar se a massagem com os óleos essenciais de Lavandula angustifólia e Pelargonium graveolens alivia a dismenorreia primária. Tratou- se de um ensaio clínico randomizado simples cego com 17 participantes que receberam esclarecimentos sobre a pesquisa e assinaram um Termo de Consentimento Livre e Esclarecido (TCLE). As participantes foram divididas de forma aleatória por meio de sorteio simples em dois grupos: o primeiro grupo recebeu massagem de 15 minutos na região abdominal com óleo de amêndoa e o segundo grupo recebeu massagem de 15 minutos na região abdominal com óleo essencial de Lavandula angustifólia (lavanda) (3%) e Pelargonium graveolens (gerânio) (2%) diluídos no óleo de amêndoa. Após o procedimento, as participantes foram avaliadas quanto a presença de dor utilizando a escala visual analógica (EVA) em dois momentos: imediatamente após o término do procedimento e 30 minutos após o procedimento. Em relação à intensidade da dor (EVA), ambos os grupos apresentaram redução significativa da dor logo após a aplicação e depois de 30 minutos do seu término em relação ao momento anterior ao procedimento. A comparação entre os grupos não mostrou diferença significativa na intensidade da dor. Conclusão: A massagem abdominal com óleo vegetal de amêndoas enriquecido ou não com óleo essencial de lavanda e gerânio é uma excelente terapia complementar para o alívio da cólica menstrual
Effect of CoO loading on electrochemical properties of activated carbon from sugarcane bagasse
Authors: Siburian Kyfti Yolanda , Nasti Al Nadine De , Sidauruk Enjeli Rotama , Oktaviano Haryo Satriya , Mitan Nona Merry M. , Efiyanti Lisna , Saputra Nur Adi , Amanah Nur Layli , Nugroho Agung 
Published: December 2024

Activated carbon is synthesized from sugarcane bagasse through a pre-carbonization process in a muffle furnace at 400 °C, followed by carbonization and activation using the pyrolysis method at 800 °C. In the activation process, pre-carbonized SB is activated using 0.1 M NaOH. The activated carbon is then impregnated with cobalt oxide (CoO) using a hydrothermal method at 110 °C to improve its electrochemical performance. After impreg­nation, the presence of CoO is confirmed by X-ray diffraction patterns. Scanning electron microscopy suggests that the samples' morphology shows pore structures. Electrochemical properties are measured by cyclic voltammetry and galvanostatic charging-discharging techniques using a three-electrode system with 1 M Na2SO4 as an electrolyte. It is found that the specific capacitance of activated carbon from SB is 89.53 F/g, while after impreg­nation with CoO, it increases to 102.04 F/g at the same current density of 0.05 A/g.