bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osseous lesions in the distal extremities of dogs with strangulating hair mats
Authors: Watson Elizabeth , Niestat Laura 
Published: November 2020

AbstractStrangulating hair mats in dogs are characterized as soft tissue injury secondary to chronically matted hair, which can encircle the extremities and constrict lymphatic tissue and local vasculature. As the tissue swells, the hair constriction tightens and may result in tissue necrosis and osseous changes secondary to ischemic necrosis. The objectives of this retrospective case series were to describe the radiographic characteristics of persistent hair mat strangulation in dogs, to identify clinical features that would distinguish between dogs with soft tissue lesions only and dogs with osseous changes and to describe the clinical outcome in these dogs. All dogs with clinically identified strangulating hair matting had radiographically identified soft tissues defects and over half of the limbs evaluated had osseous lesions including focal periostitis, bone remodeling, bone atrophy, lysis of bone, and occasionally subluxation of joints. Chronically matted hair and strangulating hair mats in dogs are recognized by veterinarians as a medical finding in animal neglect. The osseous features of strangulating hair mats have not been described in the veterinary medical literature. This study describes the clinical features and radiographic characteristics of strangulating hair mats.
Failure Modes of a Laminated Composite With Complaint Interlayers
Authors: O’Masta M. R. , Deshpande V. S. 
Published: November 2020

Abstract
Composites comprising a high-volume fraction of stiff reinforcements within a compliant matrix are commonly found in natural materials. The disparate properties of the constituent materials endow resilience to the composite, and here we report an investigation into some of the mechanisms at play. We report experiments and simulations of a prototype laminated composite system comprising silicon layers separated by polymer interlayers, where the only failure mechanism is the tensile fracture of the brittle silicon. Two failure modes are observed for such composites loaded in three-point bending: failure under the central roller in (i) the top ply (in contact with the roller) or (ii) the bottom ply (free surface). The former mode is benign with the beam retaining load carrying capacity, whereas the latter leads to catastrophic beam failure. Finite element (FE) simulations confirm this transition in failure mode and inform the development of a reduced order model. Good agreement is shown between measurements, FE simulations, and reduced order predictions, capturing the effects of material and geometric properties on the flexural rigidity, first ply failure mode, and failure load. A failure mechanism map for this system is reported that can be used to inform the design of such laminated composites.
Geometric Accuracy Prediction and Improvement for Additive Manufacturing Using Triangular Mesh Shape Data
Authors: Decker Nathan , Lyu Mingdong , Wang Yuanxiang , Huang Qiang 
Published: November 2020

Abstract
One major impediment to wider adoption of additive manufacturing (AM) is the presence of larger-than-expected shape deviations between an actual print and the intended design. Since large shape deviations/deformations lead to costly scrap and rework, effective learning from previous prints is critical to improve build accuracy of new products for cost reduction. However, products to be built often differ from the past, posing a significant challenge to achieving learning efficacy. The fundamental issue is how to learn a predictive model from a small set of training shapes to predict the accuracy of a new object. Recently an emerging body of work has attempted to generate parametric models through statistical learning to predict and compensate for shape deviations in AM. However, generating such models for 3D freeform shapes currently requires extensive human intervention. This work takes a completely different path by establishing a random forest model through learning from a small training set. One novelty of this approach is to extract features from training shapes/products represented by triangular meshes, as opposed to point cloud forms. This facilitates fast generation of predictive models for 3D freeform shapes with little human intervention in model specification. A real case study for a fused deposition modeling (FDM) process is conducted to validate model predictions. A practical compensation procedure based on the learned random forest model is also tested for a new part. The overall shape deviation is reduced by 44%, which shows a promising prospect for improving AM print accuracy.
Effect of Turbulence on the Wavefront of an Ultrahigh Intensity Laser Beam
Authors: Bellec Morgane , Girard Alain , Balarac Guillaume , Bieder Ulrich , Millet François , Luchier Nicolas 
Published: November 2020

Abstract
Ultrahigh intensity lasers face thermal management issues that limit their repetition rates. The key challenge is to efficiently evacuate the heat deposited in the amplifier by the optical pumping without impacting the output laser beam quality. The amplifier can have a multislab geometry where the laser beam crosses successive amplifying slabs and the cooling channels that separate them. This work investigates numerically how a cryogenic cooling of the amplifier by turbulent channel flows may affect the wavefront of the laser beam. To this end, large eddy simulations (LESs) representative of the amplifier cooling are performed using TrioCFD, a code developed by the CEA. First, validation simulations are carried out for heated channel flows, allowing comparisons to direct numerical simulation (DNS) results from the literature. Then, LESs of an open turbulent channel flow cooling two slabs are conducted using conjugated heat transfer between the solid and the fluid. The phase distortions, mean and fluctuations, induced by the inhomogeneous and turbulent temperature field are computed directly from the LES. A moderate although non-negligible effect of the turbulence on the laser wavefront was found. This optical effect increases when the slab heating increases. A comparison to the Sutton model, widely used in aero-optic studies, was performed, and its applicability was found limited for this problem. For the first time, TrioCFD is used to address the question of the beam impact of the cooling of laser amplifiers, and it has proven to be a valuable tool for such application.
Numerical and Experimental Investigation on Nonlinear Cyclic Collapse Response of Ship Model in Regular Waves
Authors: Liu Weiqin , Huang Yu , Li Ye , Song Xuemin , Wei Fangyi , Wu Xiaoni 
Published: November 2020

Abstract
Large ocean waves with large wave height may destroy the ship’s structure, whereas it is difficult to predict the nonlinear dynamic strength in the large waves. In this study, we used a nonlinear simulation based on boundary element method (BEM)-finite element method (FEM) and a collapse experiment of ship model to study dynamic ultimate strength and dynamic course of collapse of ship structure, the collapse test was performed in regular tank wave. Besides, a simulation method for nonlinear dynamic ship strength was proposed to predict and compare the results of collapse test. A collapsed model consisting of a plastic hinge and two ship strips is designed. Subsequently, we performed the nonlinear simulation of the ultimate strength of ship model induced by tank wave. Wave loads were calculated following potential theory and BEM. Next, ship structural FEM model was modeled, the ship pressure was transferred to ship wet surface elements, and inertia force was exerted as well. Finally, the nonlinear dynamic strength calculation of ship model was performed in accordance with nonlinear FEM. A four-point-bending test adopted displacement controlling method was designed to obtain the hysteresis characteristic of the elastoplastic hinge. Hysteretic test and simulation analysis was performed to determine post-ultimate bending moment. Time-domain computational results including rotation angle history and vertical bending moment are close to collapse test results so that the two methods are verified. This study verifies that structural nonlinearities of ship structure induced by wave loads could be predicted.
Fabrication of Six Degrees-of-Freedom Hexflex Positioner With Integrated Strain Sensing Using Nonlithographically Based Microfabrication
Authors: Panas Robert M. , Culpepper Martin L. 
Published: November 2020

Abstract
A process flow is described for the low cost, flexible fabrication of metal micro-electromechanical systems (MEMS) with high performance integrated sensing. The process is capable of producing new designs in ≈1 week at an average unit cost of &lt;$1 k/device even at batch sizes of ≈1–10, with expected sensing performance limits of about 135 dB over a 10 kHz sensor bandwidth. This is a ≈20× reduction in cost, ≈25× reduction in time, and potentially &gt;30× increase in sensing dynamic range over comparable state-of-the-art compliant nanopositioners. The nonlithographically based microfabrication (NLBM) process is uniquely suited to create high performance nanopositioning architectures which are customizable to the positioning requirements of a range of nanoscale applications. These can significantly reduce the cost of nanomanufacturing research and development, as well as accelerate the development of new processes and the testing of fabrication process chains without excess capital investment. A six degrees-of-freedom (6DOF) flexural nanopositioner with integrated sensing for all 6DOF was fabricated using the newly developed process chain. The fabrication process was measured to have ≈30 μm alignment. Sensor arm, flexure, and trace widths of 150 μm, 150 μm, and 800 μm, respectively, were demonstrated. Process capabilities suggest lower bounds of 25 μm, 50 μm, and 100 μm, respectively. Dynamic range sensing of 52 dB was demonstrated for the nanopositioner over a 10 kHz sensor bandwidth. Improvements are proposed to approach sensor performance of about 135 dB over a 10 kHz sensor bandwidth.
Electrically Activated Reaction Synthesis of Ni-CNT/Al Hierarchical Composite Powders
Authors: Modi P. , Chauhan M. , Bundy V. , Morsi K. 
Published: November 2020

Abstract
The present study investigates the fabrication of Ni3Al-carbon nanotube (CNT) nanocomposite using electrically activated reaction synthesis (EARS) and its effects on the mechanical properties of the nanocomposite. The effect of initial nickel (Ni) particle size and mechanical milling time of Ni-CNT/Al hierarchical composite powder on reaction characteristics, product microstructure and properties was investigated for the first time. An increase in mechanical milling time was found to result in a decline in ignition temperature and time to ignition for the two investigated initial nickel particle sizes (4–8 µm and 45–90 µm). The smaller initial nickel particle size and longer milling times had a major influence on the homogeneity, decreasing porosity, and increasing hardness of the reacted compacts.
Fabrication and Reliability Assessment of Cu Pillar Microbumps With Printed Polymer Cores
Authors: Qiu Xing , Lo Jeffery C. C. , Cheng Yuanjie , Ricky Lee S. W. , Tseng Yong Jhe , Chiu Peter 
Published: November 2020

Abstract
Cu pillar microbumps with polymer cores have been demonstrated to effectively reduce thermomechanical stress and improve joint reliability. Fabricating polymer cores by a printing approach was proposed to overcome the limitations in conventional fabrication process. Cylindrical polymer cores with diameter of 20 μm and height of 30 μm were successfully printed. Surface metallization was subsequently applied on the printed polymer cores and Cu pillar microbumps with printed polymer cores with diameter of 35 μm and height of 35 μm were eventually achieved. To study the reliability performance of the interconnect joints made of Cu pillar microbumps with printed polymer cores, flip-chip bonding technology was successfully introduced and the interconnect joints between a designed bismaleimide triazine (BT) substrate and a silicon chip were formed. The interconnect joints made of conventional Cu pillars with identical dimensions were prepared for comparison. The reliability performance of the joints was investigated under temperature cycling condition and drop condition, respectively. Printed polymer cores increased the characteristic life by 32% in a temperature cycling test (0–100 °C), while the drop test showed that printed polymer cores increased the characteristic life by four times due to the extra compliance provided by the printed polymer cores. It can be concluded that Cu pillar microbumps with printed polymer cores can effectively reduce stress and improve joint reliability.
Guide to interventional radiology in cats and dogs
Authors: Kent Andrew 
Published: November 2020

BackgroundInterventional radiology covers a group of procedures that are performed under imaging guidance, including fluoroscopy, endoscopy, ultrasound and computed tomography. The procedures are minimally invasive and tend to use percutaneous access or natural orifices to access the target area and deliver a treatment.Aim of the articleThis article provides a review of the currently performed interventional radiology procedures, including cardiorespiratory, urogenital, hepatobiliary/gastrointestinal and vascular techniques.
Cross-validation of four different survey methods used to estimate illicit cigarette consumption in Brazil
Authors: Szklo André Salem , Iglesias Roberto Magno , Stoklosa Michal , Figueiredo Valeska Carvalho , Welding Kevin , de Souza Junior Paulo Roberto Borges , Machado Alessandra Trindade , Martins Luis Felipe Leite , Nascimento Hannah , Drope Jeffrey 
Published: November 2020

ObjectiveTo cross-validate estimates of the size of the illicit cigarette trade based on the results of four different survey methods.MethodsIn 2018/2019, four non-industry-funded, large-scale studies were conducted in selected Brazilian cities: packs discarded in household garbage/PDG (1 city), packs littered in the streets/PLS (5 cities), a phone survey of tobacco users’ purchase behaviors/VIGITEL (5 cities), and a face-to-face household survey of tobacco users’ purchase behaviors/FTF-household (2 cities). The proportions of illicit cigarettes consumed were based on the price paid by smokers in their last purchase (VIGITEL or FTF-household) and/or direct observation of brand names and health warnings (PDG, PLS or FTF-household).ResultsBased on PLS, the share of packs that avoided taxation ranged from 30.4% (95% CI 25.6% to 35.7%) in Rio de Janeiro to 70.1% (95% CI 64.6% to 75.0%) in Campo Grande; and PDG conducted in Rio de Janeiro found an even lower proportion point estimate of illicit cigarette use (26.8%, 95% CI 25.1% to 28.6%). In FTF-household, the share of illicit cigarette consumption based on the self-reported price ranged from 29.1% (95% CI 22.4% to 35.7%) in Rio de Janeiro to 37.5% (95% CI 31.2% to 43.7%) in São Paulo, while estimates based on pack observation ranged from 29.9% (95% CI 23.3% to 36.5%) in Rio de Janeiro to 40.7% (95% CI 34.3% to 47.0%) in São Paulo. For all cities, VIGITEL presented the lowest levels of illicit consumption, and most illicit brands were produced in Paraguay.ConclusionsSmall differences in the estimated levels of illicit trade across methods were found, except for the phone survey. The cross-validation of estimates from independent studies is important to help effectively implement tobacco excise tax policy in Brazil and other low-income and middle-income countries.
Gravitational dynamics in the toy model of the Higgs-dark matter sector: the field theoretic perspective
Authors: Nakonieczna Anna , Nakonieczny Łukasz 
Published: November 2020

AbstractThe objective of the paper was to examine gravitational evolutions in the Higgs-dark matter sector toy model. The real part of the Higgs doublet was modelled by a neutral scalar. Two dark matter candidates introduced were the dark photon and a charged complex scalar. Non-minimal couplings of both scalars to gravity were included. The coupling channels between the ordinary and dark matter sectors were kinetic mixing between the electromagnetic and dark U(1) fields and the Higgs portal coupling among the scalars. The structures of emerging singular spacetimes were either of Schwarzschild or Reissner–Nordström types. The non-minimal scalar–gravity couplings led to an appearance of timelike portions of apparent horizons where they transform from spacelike to null. The features of dynamical black holes were described as functions of the model parameters. The black holes formed later and their radii and masses were smaller as the mass parameter of the complex scalar increased. The dependencies on the coupling of the Higgs field to gravity exhibited extrema, which were a maximum for the time of the black holes formation and minima in the cases of their radii and masses. A set of quantities associated with an observer moving with the evolving matter was proposed. The energy density, radial pressure and pressure anisotropy within dynamical spacetimes get bigger as the singularity is approached. The increase is more considerable in the Reissner–Nordström spacetimes. The apparent horizon local temperature changes monotonically in the minimally coupled case and non-monotonically when non-minimal scalar–gravity couplings are involved.
Effect of different welding energy on microstructure and toughness of HAZ of low carbon bainitic steel
Authors: Wang Hong , Yang Liang 
Published: November 2020

Low carbon bainitic steel (LCBS) with excellent combined properties is the first choice for materials of pipeline transiting geological disaster. However, welding will worsen its toughness. In this paper, three kinds of welding heat input were designed to study the relationship between the toughness and microstructure in the coarse grain zone of welding heat affect zone (CGHAZ) of LCBS. The evolution characteristics of the microstructure of LCBS and the CGHAZ, and impact fracture were investigated by optical microscopy (OM), scanning electron microscopy (SEM). The results indicated that microstructure of LCBS consists mainly of bainite ferrite (BF) and granular bainite (GB). Heat input for 22 kJ/cm, the original austenite grains become coarsening, the microstructure is a small amount of quasi polygonal ferrite (QF) and polygonal ferrite (PF), which exhibits low Charpy impact toughness. However, for heat input of 19 kJ/cm, the degree of grain coarsening is small and distribution of martensite-austenite (M-A) constituents is the chain. The statistics of image software show that with the increase of heat input (16–22 kJ/cm), the average grain size of original austenite is basically the same (25 um), which is mainly due to Nb solute drag restraint the growth of austenite grain.
CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia
Authors: Deer Evangeline , Reeve Kristin E. , Amaral Lorena , Vaka Venkata Ramana , Franks Michael , Campbell Nathan , Fitzgerald Sarah , Herrock Owen , Ibrahim Tarek , Cornelius Denise , LaMarca Babbette 
Published: November 2020

The reduced uterine perfusion pressure (RUPP) rat model and normal pregnant (NP) rat recipients of RUPP CD4+ T cells recapitulate many characteristics of preeclampsia such as hypertension and oxidative stress. We have shown an important hypertensive role for natural killer (NK) cells to cause mitochondrial dysfunction in RUPP rats; however, the role for RUPP CD4+ T cells to stimulate NK cells is unknown. Therefore, we hypothesized that RUPP-induced CD4+ T cells activate NK cells to cause mitochondrial dysfunction/reactive oxygen species (ROS) as mechanisms of hypertension during pregnancy. We tested our hypothesis by adoptive transfer of RUPP CD4+ T cells into NP rats or by inhibiting the activation of RUPP CD4+ T cells with Orencia (abatacept) and examining hypertension, NK cells, and mitochondrial function. RUPP was performed on gestation day (GD) 14, and splenic CD4+ T cells were isolated on GD 19 and injected into NP rats on GD 13. In a separate group of rats, Orencia was infused and the RUPP procedure was performed. Mean arterial pressure and placental and renal mitochondrial ROS increased in RUPP ( n = 7, P < 0.05) and NP + RUPP CD4+ T-cell recipients ( n = 13, P < 0.05) compared with control NP ( n = 7) and NP + NP CD4+ T-cell recipients ( n = 5) but was reduced with Orencia ( n = 13, P < 0.05). Placental and renal respiration was reduced in RUPP ( n = 6, P < 0.05) and NP + RUPP CD4+ T-cell recipients ( n = 6, state 3 P < 0.05) compared with NP ( n = 5) and NP + NP CD4+ T-cell recipients ( n = 5) but improved with Orencia ( n = 9, n = 8 P < 0.05). These data indicate that CD4+ T cells, independent of NK cells, cause mitochondrial dysfunction/ROS contributing to hypertension in response to placental ischemia during pregnancy.
Fats and Mets, KRAS-Driven Lipid Dysregulation Affects Metastatic Potential in Pancreatic Cancer
Authors: Man Jennifer , Pajic Marina , Joshua Anthony M. 
Published: November 2020

Abstract
In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of preloaded lipids on an invasive phenotype, the authors then establish that oncogenic KRAS mutation downregulates HSL, thereby facilitating lipid storage during steady state. Thereafter, a phenotypic switch to oxidative metabolism with lipid utilization to fuel invasion and metastasis occurs. Experimentally, blocking the KRAS–HSL axis results in fewer lipid droplets, as well as metabolic reprogramming of the invasive cell phenotype, effectively reducing invasive capacity of KRAS-mutant pancreatic cancer. Of note, HSL overexpression in tumor cells also inhibited invasion, due to depletion of lipid droplets and the stored lipids, which are essential during invasion. Collectively, these novel findings highlight the importance of energy metabolism and its dynamic regulation in the evolution of the metastatic capacity of pancreatic cancer.
See related article by Rozeveld et al., p. 4932
Premature Years of Life Lost Due to Cancer in the United States in 2017
Authors: Song Minkyo , Hildesheim Allan , Shiels Meredith S. 
Published: November 2020

Abstract

Background:
Burden of cancer mortality is often measured by death counts or mortality rates, but potential years of life lost (PYLL) and PYLL per death may be more useful to estimate the impact of cancer-related deaths occurring at younger ages.

Methods:
We used U.S. national death certificate data. A total of 45 categories of common cancers were grouped for cancer-specific calculations of PYLL and PYLL per death. PYLL was defined as the sum of the total years of life lost prior to age 75 years.

Results:
The largest number of PYLL in 2017 was due to deaths from cancers of the lung/bronchus (891,313; 20.8%), colon/rectum (409,538; 9.6%), and breast (400,643; 9.4%). Cancers with the highest PYLLs generally also caused the largest number of deaths and had the highest mortality rates, with the exception of prostate cancer (5.1% of deaths, 2.0% of PYLL). In contrast, PYLLs per death were greatest for deaths due to cancers of testis (mean = 34.0 years), bones/joints (26.4), and other endocrine sites including thymus (25.2).

Conclusions:
Although PYLLs generally reflect mortality rates, they more heavily weigh cancers that occur at younger ages. In contrast, PYLL per death, which is an average quantification of life years lost for individual patients with cancer, shows a different pattern.

Impact:
Mortality rates, PYLL, and PYLL per death are complementary measures of the burden of deaths due to cancer that should be considered in tandem to prioritize public health interventions focused on preventing premature mortality.