bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemetaan Objek Wisata Desa Pandanrejo Kota Batu Berbasis Geographic Information System (GIS)
Authors: Restu Wardani Nila , Maulana Malik Jamil Achmad 
Published: September 2020

Abstrak: Desa Pandanrejo merupakan desa wisata di Kecamatan Bumiaji Kota Wisata Batu. Tujuan penelitian yaitu memetakan sembilan objek wisata menggunakan aplikasi Arc. GIS 3.3. Pemetaan ini berguna untuk memberikan informasi kepada wisatawan tentang data spasial objek dan daya tarik wisata. Metode yang digunakan adalah survei dengan menetukan titik koordinat setiap objek wisata. Selanjutnya titik koordinat dijadikan input data pada aplikasi Arc.GIS 3.3. Pengumpulan data primer dilakukan dengan cara observasi langsung ke objek wisata. Pengumpulan data sekunder meliputi Citra Quickbird Desa Pandanrejo, serta Peta Rupa Bumi Indonesia (RBI). Analisis data dilakukan secara deskriptif. Berdasarkan hasil pemetaan objek wisata di Desa Pandanrejo, maka ada sembilan objek wisata diantaranya: enam objek wisata alam dan tiga objek wisata budaya. Kesembilan objek wisata ini tersebar di empat dusun. Masing-masing objek wisata memiliki daya tarik wisata tersendiri berupa keindahan alam dan keunikan budaya.
Abstract: Pandanrejo Village is a tourism village in Bumiaji District, Batu Tourism City. The purpose of this study is to map nine tourism destination using the Arc. GIS 3.3 application. This mapping is useful to provide information to tourists about the spatial data of tourism destination. The study used survey method by determining the coordinates of each tourism destination. Furthermore, the coordinates are used as input data in the Arc.GIS 3.3 application. Primary data collection by direct observation to tourism destination. Secondary data collection are the Quickbird Image of Pandanrejo Village, as well as the Rupa Bumi Indonesia(RBI) map. Data analysis was performed descriptively. Based on the results of the mapping of attractions in the village of Pandanrejo, there are nine tourism destination: six natural tourism destination and three cultural tourism destination. These nine attractions are scattered in four hamlets. The tourism destination has its own tourist of natural beauty and cultural uniqueness.
Influence of the distortion type on the image quality assessment when reducing its sizes
Authors: Asatryan D. G. , Harutyunyan M. E. , Golub Y. I. , Starovoitov V. V. 
Published: September 2020

In this paper, the influence of various types of distortion of an image on its quality while reducing its sizes, is investigated. To assess the image quality, it is proposed to use the method of comparison with the standard using a previously developed measure based on the proximity of the values of the parameters of the Weibull distribution, which describes the gradient field of the image. The well-known TID2013 image database was used as the material, which includes 3000 images distorted by 24 types of distorting algorithms with five levels. Each image of the base was reduced by 2, 4 and 8 times by the two most common methods and compared with the original image-original. The calculations were performed for five types of distortions implemented in the database. To make a decision on the acceptability of the applied quality measure, the calculated measure values were compared with the subjective quality ratings provided along with the documentation on the TID2013 database. The comparison was carried out using Spearman’s correlation coefficient. It is shown that the average values of correlations for all images at three types of distortions are very high, while for the other two they are unacceptably low. An attempt has been made to explain this situation by the properties of distorting algorithms that change the structural properties of the image to varying degrees.The possibility of comparing images of the same scene, but with different resolutions, is demonstrated.
Parental Communication On Sexual And Reproductive Health Issues To Their Adolescents And Affecting &nbsp;Factors At Asella Town, Ethiopia; A Community Based Cross Sectional Study
Authors: Bekele Daniel , Deksisa Abdi , Abera Wondu , Megersa Getu 
Published: September 2020

Abstract
Background: Parents’ communication on sexual and reproductive health issues with their adolescent plays a great role in preventing morbidity and mortality associated with sexual behavior. However lack of parent to adolescent communication was a serious problem in Ethiopia resulted in teenage pregnancy, unsafe abortions, sexually transmitted infections, school problems, and other sexual risk behaviors. Parents have high responsibility on cultivating their son and daughter regarding to sexual and reproductive health issues. Therefore, the aim of this study was to investigate the level of parent’s communication with their adolescents and affecting factors in Ethiopia. Methods: A community based cross- sectional survey was conducted on 347 randomly selected parents of 10–19 year old teenagers. A random sampling was used to sample the study participants. A pre-tested and structured questionnaire as used to collect data. A binary and multivariable logistic regression analysis was conducted for adjusted odds ratio (AOR) at 95% confidence interval (CI), variables at a P-value <0.05 were considered as significant association. Results: The study showed that, 23.1% of parents had communication on SRH issues with their adolescents. Factors computed for adjusted odds ratio [AOR], such as parents completed some form of education (being grades 9–12 [AOR= 2.42, 95% CI: 1.06-5.53]; diploma and above [AOR=4.78, 95% CI: 2.03-11.21]; having good knowledge [AOR =3.08, 95% CI: 1.89-5.39]; and being having positive attitudes [AOR 3.03, 95% CI: 1.37-6.70] were significantly affect the communication.Conclusion: This study revealed that a low proportion of parents’ communication on sexual and reproductive health issues with their adolescents and multidimensional factors appear to determine their discussion. Thus, promotion of parent to adolescent communication, parents training and addressing the importance of parent to young people communication to all parents along with health care providers was important.
Investigating the role of opiorphin genes in prostate cancer and the possible genetic mechanisms by which they modulate tumor growth and androgen-sensitivity.
Authors: Mukherjee Amarnath , Park Augene , Wang Li , Davies Kelvin Paul 
Published: September 2020

Abstract
Background The opiorphin family of genes (represented in humans by ProL1, hSMR3A and hSMR3B) encode peptides which act as potent neutral endopeptidase (NEP) inhibitors. Because modulated NEP activity is associated with cancer development it has been suggested that dysregulated opiorphin expression may be involved in oncogenesis and recent reports have associated upregulated opiorphin gene expression with breast and oropharyngeal cancer. These observations prompted the present studies to determine if opiorphin genes play a role in prostate cancer (PrCa).Methods Publicly available data bases were screened for evidence associating opiorphin gene expression with PrCa and the findings confirmed using PrCa tissue arrays. Androgen-insensitive (PC3) and -sensitive (LNCaP) PrCa cells were engineered to overexpress ProL1, referred to as LNCaP-ProL1+ and PC3-ProL1+, respectively. Xenografted tumor growth of ProL1-overexpressing and parental cell-lines were compared in male, castrated-male and female nude mice. Changes in global gene expression resulting from overexpression of ProL1 in these cell-lines was determined by RNA-Seq.Results Publicly available datasets supported an association between overexpression of opiorphin genes and PrCa, which was confirmed using tissue arrays. Xenografted tumors derived from PC3-ProL1+ had an initial growth advantage over parent cell-lines in male mice, although at later time points there was no difference. Xenografted tumors derived from LNCaP-ProL1+ were able to grow in castrated male mice (in contrast to the parent cell-lines), and had impaired growth in female mice. Global gene expression analysis demonstrated that overexpression of ProL1 causes modulated expression of genes involved in signaling, angiogenesis and steroid response pathways.Conclusions This is the first report associating upregulated opiorphin gene expression and PrCa. Xengrafted tumors derived from the androgen-sensitive LNCaP cell-line engineered to overexpress ProL1 exhibit a more androgen-insensitive phenotype. Previous reports demonstrate opiorphins act as master regulators of the hypoxic response in smooth muscle cells. RNAseq data not only supports a similar role for ProL1 in PrCa (regulating genes involved in angiogenesis), but in addition, regulating genes involved in steroid response. Therefore, opiorphins may play a role in PrCa development by activating pathways that overcome the hypoxic environment of the developing tumor and promote the development of androgen-insensitivity.
Resumption of the Treatment for Non-COVID-19 Gynecologic Patients after Lifting Lockdown: Experiences from Wuhan
Authors: Dong Weihong , Gao Rui , Cai Jing , Yang Shouhua , Guo Jianfeng , Zhao Jing , Wang Zehua , Cai liqiong 
Published: September 2020

Abstract
Background: To share our experiences of resumption of the treatment for gynecologic patients after lifting lockdown in a hotspot area of the Corona Virus Disease 2019 (COVID-19)pandemic.Methods: The triage process used to resume the medical activities for gynecologic patients at the Wuhan Union Hospital after a 76-day lockdown of the city is described and its effectiveness to avoid COVID-19 nosocomial transmission is shown.Results:The non-emergency patients are pre-triaged by contact history and body temperature at outpatient clinic and negative COVID-19 screening tests are required for an admissionin the buffering rooms at the gynecologic department. The buffering lasts for at least three days for symptom monitoring and a second round of COVID-19 tests before they can be transferred to the regular gynecologic wards. For patients who need emergency surgery, the first screening should be completed at the quarantine wards after the surgery, followed by buffering at the gynecologic department. We received 19298 outpatient visits, admitted 326 patients, and performed 223 operations in the first two months after the lockdown was lifted, and no single COVID-19 case occurred in the hospitalized patients while the proportion of potentially high-risk patients with cancer and severe anemia were increased in comparison with the same period in 2019 and the latest two months before the lockdown.Conclusions:We provide an effective triage system with buffering at two levels to guarantee safe and timely treatment fornon-COVID-19 gynecologic patients in a post-lockdown phase.
Signature based on immune-related LncRNA can predict overall survival of osteosarcoma patients
Authors: Li Longqing , Zhang Lianghao , Khader Manhas Adbul , Zhang Yan , Lu Xinchang , Zhang Yi , Liu Yongkui , Wen Jia , Liu Tao , Yuan Yaobo , Li Jiazhen 
Published: September 2020

Abstract
Background: Osteosarcoma is a malignant bone tumor common in children and adolescents. Metastatic status remains the most important guideline for classifying patients and making clinical decisions. Despite many efforts, newly diagnosed patients receive the same therapy that patients have received over the last 4 decades. With the development of high-throughput sequencing technology and the rise of immunotherapy, it is necessary to deeply explore the immune molecular mechanism of osteosarcoma. Methods: We obtained RNA-seq data and clinical information of osteosarcoma patients from TCGA database and TARGET database. With the help of co-expression analysis we identified immune-related lncRNA and then by means of univariate Cox regression analysis prognostic-related lncRNA was screened out. And also by using least absolute shrinkage and selection operator regression method a model based on immune-related lncRNA was constructed. The differences in overall survival, immune infiltration, immune checkpoint gene expression, and tumor microenvironmental immunity type between the two groups were evaluated. Results: We constructed a signature consisting of 13 lncRNA. Our results show that signatures can reliably predict the overall survival of patients with osteosarcoma and can bring net clinical benefits. Further more, the signatures can be used for further risk stratification of the metastasis patients. Patients in the low-risk group had higher immune cell infiltration and immune checkpoint gene expression. The results from gene set variation analysis show that patients in low-risk group are closely related to immune-related pathways when compared with patients in high-risk group. Finally, patients in the low-risk group are more likely to be classified as TMIT I and hence more likely to benefit from immunotherapy. Conclusion: Our signature may be a reliable marker for predicting the overall survival of patients with osteosarcoma. Keywords: Osteosarcoma, TCGA, LncRNA, Tumor immunology, Prognosis.
Evaluation of doxorubicin-eluting bead transcatheter arterial chemoembolization combined with endovascular brachytherapy for hepatocellular carcinoma with main portal vein tumor thrombus
Authors: Wu Zhiyuan , Gong Ju , Huang Wei , Wang Qingbing , Wang Ziyin , Liu Qin , Liu Jingjing , Gu Junwei , Ding Xiaoyi , Wang Zhongmin 
Published: September 2020

Abstract
Background The goal of this study was to compare the clinical results of conventional transcatheter arterial chemoembolization (C-TACE) and doxorubicin-eluting bead transcatheter arterial chemoembolization (D-TACE) combined with endovascular stent implantation with an iodine-125 seed strand in hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombus (MPVTT).Methods This study was a prospective controlled study with follow-up dates spanning from Mar 2015 to Feb 2020. Patients with both HCC and MPVTT were randomly divided into two groups. Portal vein stents with iodine-125 seed strands were implanted first; then, C-TACE or D-TACE was administered to all patients. Objective response rates were assessed. The time to disease progression and survival rate were compared between the two groups.Results A total of 26 patients were enrolled, with 13 in each group. During follow-up, the portal stent patency times were 112.3±98.2 days in the C-TACE group and 101.7±90.4 days in the D-TACE group. The time to disease progression was 42 days in the C-TACE group and 120 days in the D-TACE group (p=0.03). The overall survival time from the first intervention procedure was 216 days in the C-TACE group and 239 days in the D-TACE group (p=0.047). The D-TACE group was superior to the C-TACE group in terms of progression-free survival (PFS) and overall survival (OS) times.Conclusion Endovascular implantation of a stent with an iodine-125 seed strand combined with TACE is safe and effective in HCC patients with MPVTT. Compared to C-TACE, D-TACE achieves more benefits regarding PFS and OS.Trial registration This study was a cohort study, no health-related interventions to evaluate the effects on health outcomes. This study wasn’t a clinical trial.
QTL Mapping of Novel Genomic Regions for Yield Related Traits in Doubled Haploid (DH) Population Derived from the Popular Rice Hybrid KRH-2
Authors: Kulkarni Swapnil Ravindra , Munuswamy Balachandran Sena , K Ulaganathan , Balakrishnan Divya , A.S. Hari Prasad , G Rekha , MBVN Kousik , Dasari Aleena , Kale Ravindra Ramarao , G Harika , M Anila , E Punniakoti , T Dilip , SK Hajira , K Pranathi , M Ayyappa Dass , Shaik Mastanbee , K Chaitra , Sinha Pragya , P Koteswara Rao , RM Sundaram 
Published: September 2020

Abstract
Background: Rice, being the principal food crop and major nutritional source for more than half of the global population, is also an important source of livelihood in many South and South-East Asian countries. Amidst diminishing natural resources and many biotic-abiotic stresses, increasing the yield of rice varieties remains a challenging task. Identification of novel and yield augmenting alleles from stable rice hybrids is crucial to facilitate their marker-assisted transfer into various genetic backgrounds. Results: Quantitative trait loci (QTL) mapping using a population of 125 doubled haploid (DH) lines developed from the cross IR58025A/KMR3R and 126 polymorphic SSR; EST-derived SSR markers led to the identification of 12 each of major-minor effect QTLs for yield related traits. Major effect QTLs were detected for traits namely days to fifty percent flowering, test (1,000) grain weight, plant height, panicle weight, panicle length, flag leaf width, flag leaf length, biomass and total grain yield/plant explaining the phenotypic variability in the range of 29.95%-56.75%. QTL hotspots were detected on chromosome 3 for the traits, panicle length and total grain yield/plant and on chromosome 6 for the traits, panicle length, flag leaf length and total grain yield/plant. Though many of these QTLs were noted to co-localize with the QTL regions reported in earlier studies, five novel and major effect QTLs for panicle length, biomass, flag leaf width, panicle weight, plant height and three novel minor effect QTLs for panicle weight and fertile grains per panicle, were identified in this study. Conclusions: Through this study, both major-minor effect novel QTLs for crucial yield related traits, viz., fertile grains per panicle, panicle length, panicle weight were identified. Further, the QTL hotspots identified on two different chromosomes for flag leaf length, panicle length and total grain yield/plant shall not only help in understanding the underlying genetic mechanisms of yield regulation but also would provide an insight into the genetic synchrony among the various yield related traits in contributing for yield heterosis. The identified QTL hotspots after their validation can be deployed in breeding programs targeted towards improvement of yield heterosis.
PD-L1 Expression Enhancement by Tumor-Associated Macrophages Derived Osteopontin Leads to Poor Non-Small Cell Lung Caner Prognosis
Authors: Li Yue , Liu Hai-lin , Yue Dong-sheng , Chen Chen , Li Chen-guang , Zhang Zhen-fa , Xu Sheng-qiang , Lu Hui-ping , Gu Tian-tian , Wang Chang-li 
Published: September 2020

Abstract
Background In the tumor microenvironment, programmed death ligand 1(PD-L1) is a key protein upregulated by tumor cells in immune escape. Tumor-associated macrophages (TAMs) play a major role in this immunosuppression. Osteopontin (OPN) is related to tumor metastasis and proliferation and immunosuppression. OPN is expressed not only by tumor cells, but also by TAMs. However, little is known of the relationship between OPN expressed by TAMs(TOPN) and PD-L1 in non-small cell lung cancer.MethodsTissue microarray was used to detect the expression of TOPN, TAMs and PD-L1 by multiple quantitative fluorescence staining in 509 NSCLC patients undergoing complete pulmonary resection. The correlations between TOPN, PD-L1 and clinicopathologic data were analyzed. And in vitro cell cocultures were further conducted to investigate the crosstalk between TOPN and Neoplastic PD-L1. The in vivo efficacy of TOPN was evaluated for PD-L1 expression in subcutaneous coculture mouse model of NSCLC.ResultsWe observed a positive association between the TOPN and PD-L1 expression in tumor tissues from 509 patients with NSCLC. In addition, survival analysis revealed that TOPN and PD-L1 were independent prognostic factors for overall survival(OS) and disease-free survival(DFS) of NSCLC patients. We further demonstrated that TOPN upregulated PD-L1 expression in NSCLC cells through NF-κB pathway in vitro. And the upregulation was inhibited by neutralization with anti-OPN antibody or NF-κB inhibitor after co-culture with macrophages. TOPN induced the PD-L1 expression in tumor-bearing mice, and promoted the tumor growth.ConclusionsTOPN/NF-κB axis plays a critical role in PD-L1 expression of NSCLC microenvironment. TOPN could be a potential therapeutic target for NSCLC.
Bone Resorption Induced by Titanium Implantation Through Activation of Osteoclast Formation via C3a
Authors: Liu Xiaohan , Li Siwen , Meng Yuan , Fan Yu , Shi Ce , Ren Feilong , Wu Lin , Wang Jinyan , Sun Hongchen 
Published: September 2020

Abstract
Titanium implantation is widely used for dental replacement with advantages of excellent mechanical strength, corrosion resistance, chemical stability and biocompatibility. Some patients, however, are subject to the failure of implantation due to bone resorption, which closely related to the inflammatory responses without clear mechanisms. In this study, first we found that there were inflammatory responses and increases of osteoclasts in the surrounding tissues near by the titanium implant. Further, data revealed that the C3 was increased in the serum and surrounding tissues near by the titanium implant, and activated by classical and alternative pathways. Next, we recognized that the C3a/C3aR, no C3b played an important role in stimulating secretions of pro-inflammatory cytokines of TNF-α and MMP9 via transcription factors NF-kB and NFATc1. This cascade of responses to titanium implant leaded the differentiation and proliferation of osteoclasts in vivo and in vitro, bone resorption of surrounding tissues of Ti implant. These suggest that the cleaved C3a fragment plays predominant roles in the activation of osteoclast. Therefore, the blocking C3a activation should provide potential to prevent bone resorption and prolong the survival of biomaterial implants.
Cancer Path in Switzerland: Making the Patient an Ally to Increase Health Outcomes and Quality of Life
Authors: Lomazzi Marta , Borisch Bettina 
Published: September 2020

Abstract
BackgroundPrevalence, complexity and costs of cancer care are increasing in Switzerland. Losses in efficiency, resources and inadequate attribution hamper health outcomes. This study investigated possibilities for improvement across the whole cancer path, with a special focus on patients-care provider communication and effective approaches to strengthening interprofessional collaboration.MethodsKey stakeholders were selected based on their expertise in different areas of the cancer path and were invited to take part in interviews. Subsequently, a DELPHI-like method was applied, followed by two focus groups.ResultsThere is a prominent need for collaboration and trans-sectoral action in cancer care, encompassing clinical disciplines, communication strategies and professional attitudes. The necessity and demand for collaboration meets a highly fragmented landscape of cancer in Switzerland with a hierarchical organization of medical care entities and competition. Conclusions Pressing developments are happening in the healthcare system given the rising prevalence of some cancers, the demographics of the Swiss population and the growing number of cancer survivors. More fundamental solutions should be developed and implemented to meet patients’ needs and improve health outcomes: Are care providers and patients assuming their responsibilities for change? Will economic interests and power games boycott this change? The article tries to respond.