bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radio emission during the formation of stellar clusters in M 33
Authors: Corbelli Edvige , Braine Jonathan , Tabatabaei Fatemeh S. 
Published: May 2020

Aims. We investigate thermal and nonthermal radio emission associated with the early formation and evolution phases of young stellar clusters (YSCs) selected by their mid-infrared (MIR) emission at 24 μm in M 33. We consider regions in their early formation period, which are compact and totally embedded in the molecular cloud, and in the more evolved and exposed phase.
Methods. Thanks to recent radio continuum surveys between 1.4 and 6.3 GHz we are able to find radio source counterparts to more than 300 star forming regions of M 33. We identify the thermal free–free component for YSCs and their associated molecular complexes using the Hα line emission.
Results. A cross-correlation of MIR and radio continuum is established from bright to very faint sources, with the MIR-to-radio emission ratio that shows a slow radial decline throughout the M 33 disk. We confirm the nature of candidate embedded sources by recovering the associated faint radio continuum luminosities. By selecting exposed YSCs with reliable Hα flux, we establish and discuss the tight relation between Hα and the total radio continuum at 5 GHz over four orders of magnitude. This holds for individual YSCs as well as for the giant molecular clouds hosting them, and allows us to calibrate the radio continuum–star formation rate relation at small scales. On average, about half of the radio emission at 5 GHz in YSCs is nonthermal with large scatter. For exposed but compact YSCs and their molecular clouds, the nonthermal radio continuum fraction increases with source brightness, while for large HII regions the nonthermal fraction is lower and shows no clear trend. This has been found for YSCs with and without identified supernova remnants and underlines the possible role of massive stars in triggering particle acceleration through winds and shocks: these particles diffuse throughout the native molecular cloud prior to cloud dispersal.
ACC-AHA Diagnostic Criteria for Hypertension in Pregnancy Identifies Patients at Intermediate Risk of Adverse Outcomes
Authors: Darwin Kristin C. , Federspiel Jerome J. , Schuh Brittany L. , Baschat Ahmet A. , Vaught Arthur J. 
Published: May 2020

Objective The aim of the study is to compare maternal and neonatal outcomes among patients who are normotensive, hypertensive by Stage I American College of Cardiology-American Heart Association (ACC-AHA) criteria, and hypertensive by American College of Obstetricians and Gynecologists (ACOG) criteria.
Study Design Secondary analysis of a prospective first trimester cohort study between 2007 and 2010 at three institutions in Baltimore, MD, was conducted. Blood pressure at 11 to 14 weeks' gestation was classified as (1) normotensive (systolic blood pressure [SBP] <130 mm Hg and diastolic blood pressure [DBP] <80 mm Hg); (2) hypertensive by Stage I ACC-AHA criteria (SBP 130–139 mm Hg or DBP 80–89 mm Hg); or (3) hypertensive by ACOG criteria (SBP ≥140 mm Hg or DBP ≥90 mm Hg). Primary outcomes included preeclampsia, small for gestational age (SGA) neonate, and preterm birth.
Results Among 3,422 women enrolled, 2,976 with delivery data from singleton pregnancies of nonanomalous fetuses were included. In total, 20.2% met hypertension criteria (Stage I ACC-AHA n = 254, 8.5%; ACOG n = 347, 11.7%). The Stage I ACC-AHA group's risk for developing preeclampsia was threefold higher than the normotensive group (adjusted relative risk [aRR] 3.70, 95% confidence interval [CI] 2.40–5.70). The Stage I ACC-AHA group had lower preeclampsia risk than the ACOG group but the difference was not significant (aRR 0.87, 95% CI 0.55–1.37). The Stage I ACC-AHA group was more likely than the normotensive group to deliver preterm (aRR 1.44, 95% CI 1.02–2.01) and deliver an SGA neonate (aRR 1.51, 95% CI 1.07–2.12). The Stage I ACC-AHA group was less likely to deliver preterm compared with the ACOG group (aRR 0.65, 95% CI 0.45–0.93), but differences in SGA were not significant (aRR 1.31, 95% CI 0.84–2.03).
Conclusion Pregnant patients with Stage I ACC-AHA hypertension in the first trimester had higher rates of preeclampsia, preterm birth, and SGA neonates compared with normotensive women. Adverse maternal and neonatal outcomes were numerically lower in the Stage I ACC-AHA group compared with the ACOG group, but these comparisons only reached statistical significance for preterm birth. Optimal pregnancy management for first trimester Stage I ACC-AHA hypertension requires active study.
Key Points
Interleukin-6 as a Biomarker of Early-Onset Neonatal Sepsis
Authors: Cortés José S. , Losada Paula X. , Fernández Laura X. , Beltrán Emilce , DeLaura Isabel , Narváez Carlos F. , Fonseca-Becerra Carlos Eduardo 
Published: May 2020

Objective The aim of this study is to determine the utility of C reactive protein (CRP) and interleukin (IL)-6 in the diagnosis of neonatal sepsis (NS) in a neonatal intensive care unit (NICU) in the south of Colombia.
Study Design A nonmatched case–control study was conducted. Convenience sampling was performed. Data were obtained from clinical records. IL-6 levels were determined using enzyme-linked immunosorbent assay. Receiver operator characteristic (ROC) curve analysis and Youden's index were used to determine the optimal cutoffs for CRP and IL-6 levels in diagnosing NS, early-onset NS (EONS), and late-onset NS (LONS).
Results Data from 31 cases and 62 controls were included. History of chorioamnionitis (infinite odds ratio [OR] [3.07-infinity]), and the presence of meconium-stained amniotic fluid during birth (OR: 9.04 [1.35–112]) were identified as risk factors for NS. Differences in CRP (p < 0.0001) and IL-6 (p < 0.0485) levels were also found, more significantly for LONS and EONS patients, respectively. In the diagnosis of LONS using CRP levels, the area under the ROC curve (AUC) was 0.8371 (p < 0.0001). The optimal cutoff was 0.53 mg/dL. For EONS diagnosis using IL-6, the AUC was 0.6869 (p = 0.0315) and the optimal cutoff was 17.75 pg/mL.
Conclusion Differences between CRP and IL-6 levels were found between control and NS groups. Furthermore, CRP showed greater potential diagnostic utility in the LONS group, whereas IL-6 showed greater potential utility in the EONS group.
Key Points
Hemorrhage Risk Assessment on Admission: Utility for Prediction of Maternal Morbidity
Authors: Ahmadzia Homa K. , Phillips Jaclyn M. , Kleiman Rose , Gimovsky Alexis C. , Bathgate Susan , Luban Naomi L.C. , Amdur Richard L. 
Published: May 2020

Objective Hemorrhage is a major cause of maternal morbidity and mortality prompting creation of innovative risk assessment tools to identify patients at highest risk. We aimed to investigate the association of hemorrhage risk assessment with maternal morbidity and to evaluate maternal outcomes after implementation of the risk assessment across hospital sites.
Study Design We conducted a retrospective cohort analysis of a multicenter database including women admitted to labor and delivery from January 2015 to June 2018. The Association of Women's Health, Obstetric and Neonatal Nurses risk assessment tool was used to categorize patients as low, medium, or high risk for hemorrhage. Multivariate logistic regression was used to describe the association between hemorrhage risk score and markers of maternal morbidity and evaluate maternal outcomes before and after standardized implementations of the risk assessment tool.
Results In this study, 14,861 women were categorized as low risk (26%), 26,080 (46%) moderate risk, and 15,730 (28%) high risk (N = 56,671 births). For women with high-risk scores, the relative risk (RR) ratio compared with low-risk women was 4.9 (RR: 95% confidence interval [CI]: 3.2–7.4) for blood transfusion and 5.2 (RR: 95% CI: 4.6–5.9) for estimated blood loss (EBL) ≥ 1,000 mL. For the second objective, 110,633 women were available for pre- and postimplementation analyses (39,027 and 71,606, respectively). A 20% reduction in rates of blood transfusion (0.5–0.4%, p = 0.02) and EBL ≥ 1,000 mL (6.3–5.9%, p = 0.014) was observed between pre- and postimplementations of the admission hemorrhage risk assessment tool.
Conclusion Women who were deemed high risk for hemorrhage using a hemorrhage risk assessment tool had five times higher risk for blood transfusion and EBL ≥ 1,000 mL compared with low-risk women. Given the low incidence of the outcomes explored, the hemorrhage risk assessment works moderately well to identify patients at risk for peripartum morbidity.
Key Points
Early Gut Microbiota Changes in Preterm Infants with Bronchopulmonary Dysplasia: A Pilot Case–Control Study
Authors: Chen Shan-Ming , Lin Ching-Pin , Jan Ming-Shiou 
Published: May 2020

Objective Bronchopulmonary dysplasia (BPD) is a complex chronic lung disease that primarily affects premature or critically ill infants. This pilot study investigated early changes in gut microbiota composition in BPD patients and explored the potential risk factors associated with these changes.Study Design Preterm infants admitted to our neonatal intensive care unit with a gestational age of 26 to 32 weeks were prospectively surveyed and eligible for stool collection on days 7 and 28 of postnatal age between February 2016 and June 2017. A 16S rRNA sequencing approach was applied to compare the gut microbiota composition between the BPD group and controls. Multiple linear regression analysis was used to identify the predictor variables.Results Eight subjects in the BPD group and 10 subjects in the preterm group were analyzed during the observation period. Actinobacteria, Proteobacteria, Bacteroidetes, and Firmicutes were the four dominant bacteria phyla of intestinal microflora. A significantly lower diversity of gut microbiota was observed in the BPD group compared with the preterm group on day 28 (number of observed operational taxonomic units, p = 0.034; abundance-based coverage estimator, p = 0.022; Shannon index, p = 0.028). Multiple linear regression analysis revealed that high Neonatal Therapeutic Intervention Scoring System score (≧19) at 24 hours was statistically significant in predicting the proportion of aerobic with facultative anaerobic bacteria on day 28 (p = 0.002).Conclusion Infants with BPD are prone to develop gut dysbiosis in early life. A higher severity of illness and treatment intensity may indicate a higher risk of disrupting an anaerobic environment in the gut during the first month of life.Key Points
Use of the RAM Cannula with Early Bubble Continuous Positive Airway Pressure Requires Higher Pressures: Clinical and In vitro Evaluations
Authors: Claassen Colleen C. , Strand Marya L. , Williams Howard L. , Hillman Noah H. 
Published: May 2020

Objective Early bubble continuous positive airway pressure (bCPAP) in the delivery room (DR) reduces early intubation, mechanical ventilation, and bronchopulmonary dysplasia. The RAM cannula, adopted for ease of patient care, is a high resistance nasal interface that, when used with bCPAP, only transmits a portion of set pressures and attenuates the bubble effects. This study aimed to review early bCPAP pressures and bCPAP failure with the RAM cannula interface over a 6-year period.
Study Design Retrospective, single-center study of infants delivered <1,250 g from 2013 to 2018 (n = 735) begun on bCPAP in the DR with the RAM cannula. In vitro testing of bCPAP pressure transmission was also performed for multiple nasal interfaces and nasal occlusion percentages.
Results The percentage of infants intubated in the DR decreased over time (59 to 42%), while the average bCPAP pressure increased from 5.3 to 6.8 cmH2O. A total of 355 infants (48%) were admitted to the neonatal intensive care unit (NICU) from the DR on BCPAP. The failure rate for bCPAP in NICU within 72 hours decreased from 45 to 24% as the maximum CPAP increased from 5.8 to 7.6 cmH2O. Pneumothorax rates did not change. CPAP pressure transmission decreased with all sizes of the RAM cannula.
Conclusion When utilizing the RAM cannula for bCPAP, higher CPAP levels were associated with decreases in DR intubations and CPAP failure within the first 72 hours. If clinicians choose to use the RAM cannula for bCPAP, they will need higher set pressures to achieve lung inflation and the beneficial oscillatory effect will be diminished.
Key Points
Mucins and Tight Junctions are Severely Altered in Necrotizing Enterocolitis Neonates
Authors: Liu Dong , Xu Yanzhen , Feng Jinxing , Yu Jialin , Huang Jinjie , Li Zhiguang 
Published: May 2020

Objective This study investigates the expression levels of mucin 1 (MUC1), MUC2, occludin, and zonula occludens-1 (ZO-1) in necrotizing enterocolitis (NEC).Study Design Intestinal specimens of surgical patients suffering from NEC (the NEC group) and intestinal specimens of patients with congenital intestinal atresia (the control group) were collected. Immunohistochemical changes in MUC1, MUC2, occludin, and ZO-1 were compared between the two groups.Results Our study showed a significant decrease in the expression levels of MUC1 (p = 0.004), MUC2 (p = 0.001), occludin (p = 0.004), and ZO-1 (p = 0.013) in neonates suffering from NEC as compared with the control group.Conclusion Mucins and tight junctions are severely altered in NEC neonates. This finding might provide clues for rupture of the intestinal barrier. Further research is needed to investigate the gene expression as well as the exact mechanisms behind these changes. This will help us better understand the role of the intestinal barrier in NEC.Key Points
Ongoing Supplementation of Probiotics to Cesarean-Born Neonates during the First Month of Life may Impact the Gut Microbial
Authors: Yang Wenqing , Tian Liang , Luo Jiao , Yu Jialin 
Published: May 2020

Objective The delivery mode is considered to be a significant influencing factor in the early gut microbiota composition, which is associated with the long-term health of the host. In this study, we tried to explore the effects of probiotics on the intestinal microbiota of C-section neonates.
Study Design Twenty-six Chinese neonates were enrolled in this study. The neonates were divided into four groups: VD (natural delivery neonates, n = 3), CD (cesarean-born neonates, n = 9), CDL (cesarean-born neonates supplemented with probiotic at a lower dosage, n = 7), and CDH (cesarean-born neonates supplemented with probiotic at a higher dosage, n = 7). Fecal samples were collected on the 3rd, 7th, and 28th day since birth. The V3–V4 region of the 16S ribosomal ribonucleic acid gene was sequenced by next-generation sequencing technology.
Results The α-diversity of the intestinal microbiota of cesarean delivery neonates was significantly lower than that of the naturally delivered neonates on the 28th day (p = 0.005). After supplementation with probiotics for 28 days, the α-diversity and the β-diversity of the gut flora in the cesarean-born infants (CDL28 and CDH28) was similar to that in the vaginally delivery infants. Meanwhile, the abundances of Lactobacillus and Bifidobacterium were significantly increased since the 3rd day of probiotic supplementation. Besides, the sustained supplementation of probiotics to neonates would help improve the abundance of the operational taxonomic units in several different Clusters of Orthologous Groups of proteins.
Conclusion This study showed that probiotics supplementation to cesarean-born neonates since birth might impact the diversity and function of gut microbiota.
Key Points
Comparative Study on Bone Mineral Densitometry in People Living with HIV with or without Highly Active Antiretroviral Therapy
Authors: Das Tutan , Devi Bhagyabati , Reema Ningthoukhongjam , Singh Thangjam Gautam 
Published: May 2020

Abstract
Introduction Human immunodeficiency virus (HIV) is a disease that affects millions of people globally and affects almost all the body systems including bone metabolism. Derangement of bone mineral density (BMD) in HIV patients is well established in international literature but least studied in India. Therefore, this study aims to determine the association between BMD change and HIV infection with or without antiretroviral therapy (ART) and compare the different regimens of ART.
Materials and Methods The cross-sectional study was conducted at the Department of Medicine and ART Center of Regional Institute of Medical Sciences, Imphal, India. A total of 50 HIV patients were screened by a central dual-energy X-ray absorptiometry (DEXA) examination for measuring BMD. Correlation of BMD with a CD4 count, and different ART regimens were also studied.
Results In our study, majority of the patients (29 [58%]) had low BMD. Of the 29 patients, 18 (36%) had osteopenia and 11 (22%) had osteoporosis. Of the ART naïve patients, 81.8% have reduced BMD. Among different ART regimens, tenofovir-based regimes were mostly associated with low BMD (52.4%). A statistically significant association between low CD4 count and low BMD was found.
Conclusion Our study concluded that HIV infection is associated with bone loss and low BMD in people living with HIV (PLHIV) irrespective of its treatment with ART. PLHIV are at a greater risk of bone loss secondary to decreased BMD. Among the ART regimens, tenofovir-based regimens are mostly associated with low BMD. Therefore, all HIV patients should be screened by DEXA scan for BMD status, and timely intervention should be started.
Informing the government or fostering public debate?
Authors: Sun Yu , Graham Todd , Broersma Marcel 
Published: May 2020

AbstractThis article focuses on a popular form of civic practice in China: casual political talk that occurs in online spaces that are not ostensibly political. We investigate how Chinese citizens engage in politics through a comparative analysis of everyday talk on health issues across three popular online discussion forums: a government-orientated forum (Qiangguo Luntan), a commercial-lifestyle forum (Tieba), and a commercial-topical forum focused on parental advice (Yaolan). Our findings show that conventional deliberation directly involving conflictual and resistant attitude against state authorities is not prominently embraced by Chinese citizens in everyday online settings. However, communal and less confrontational forms of discourse are important for the proto-political talk to turn political, thus serving as prerequisite conditions for the emergence of an online public sphere. We argue that to explain how the public sphere emerges in everyday (non-political) spaces in China, it is essential to take communal discursive forms into account.
Development of augmented reality in the basic physics practicum module
Authors: Firmansyah J , Suhandi A , Setiawan A , Permanasari A 
Published: May 2020

Abstract
This research aims to design and develop a media lab in the form of Augmented Reality applications that are used in basic physics lab module. AR applications work with a tracking system and the reconstruction of the 2D marker contained in the experimental module to display 3D video animation. The method used in this research is the development of software includes the stages of collecting and analyzing the needs, do the design and manufacturing applications, validation and testing by the user, and revision. Results of the assessment by the AR application validator media and materials are respectively 80% and 85% in the predicate is valid and may be used after minor revisions. The results of trials by students as the user indicates that the 2D marker on lab module was initially less obvious and less sensitive at the time of scanning. However, after the revision of the 2D marker on lab module, 2D AR marker was sufficiently clear and sensitive at the time of scanning so that AR can help the general practical implementation and the AR content to support the practical implementation. The results showed that the development of AR applications had been successfully carried out and the AR application can function well with the scan time 1-1.5 second at a distance of 10-20 cm and successfully used in the experimental module at an angle of <900, with the result that, AR applications in basic physics practicum module as the media are supporting practicum implementation
Identification of the ability to solve the problem of contextual physics possessed by prospective physics teachers related to basic physics content
Authors: Ma’ruf M , Setiawan A , Suhandi A , Siahaan P 
Published: May 2020

Abstract
This study aims to get an idea of the ability to solve the problem of contextual physics possessed by prospective physics teachers. The research method used is quantitative descriptive. The research subjects were 30 prospective physics teachers (27 women and 3 men) at one of the private universities in South Sulawesi Province. The instrument used for data collection is a test of the ability to solve contextual physics problems consisting of 10 items in the form of essays and problem-solving worksheets with 5 items. The use of problem-solving worksheets that include the stages of solving physical problems namely describing the problem, physical concepts, analyzing the relationship between related physical variables, representing applicable mathematics, constraints according to the problem, execution, and the results of logistical evaluation of problem-solving. The results of the study show that: 1) most students of prospective physics teachers who are the subjects of research have problem-solving abilities in the low category, 2) there is no gender bias in the ability to solve contextual physical problems. The low ability to solve the contextual problem of physics is thought to be closely related to the basic physics lecture process which is held less train the ability to solve the contextual problems.
Development of guided inquiry learning tools combined with advance organizer to increase students’ understanding of physics concept
Authors: Kusdiastuti M , Gunawan G , Harjono A , Nisyah M , Herayanti L 
Published: May 2020

Abstract
The combination of guided inquiry learning models combined with advanced organizers is needed to facilitate students who have diverse initial abilities so that they can participate in inquiry activities well. The purpose of this study is to produce a physics learning device in a guided inquiry model that is combined with an advance organizer, who has valid, practical, and effective criteria in improving students understanding of the physics concept. The learning tools testing phase was carried out in class X in one of the high schools in the Mataram, using one group pre-test post-test design. Observation and concept understanding tests do data collection. The results of the study show that: Learning tools developed are valid; The practicality of learning tools was tested through the implementation of physics learning by the guided inquiry model combined with advance organizer, and the effectiveness of the learning tools can increase student understanding of physics concepts. These results indicate that the learning device developed has valid, practical, and effective criteria to increase student’ understanding of the physics concept.