bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of PI3K/Akt/NF-kB Signaling Mediates Swedish Snus Induced Proliferation and Apoptosis Evasion in the Rat Forestomach: Modulation by Blueberry
Authors: Ranjani Singaraj , Kowshik Jaganathan , Sophia Josephraj , Nivetha Ramesh , Baba Abdul B. , Veeravarmal Veeran , Joksić Gordana , Rutqvist Lars E. , Nilsson Robert , Nagini Siddavaram 
Published: November 2019

Background and Objective:
The present study was undertaken to ascertain whether the modulatory
effects of blueberries on cell proliferation induced by Swedish snus in the rat forestomach epithelium is mediated
via abrogation of the PI3K/Akt/NFκB signaling axis that regulates cell fate decision.

Methods:
The transcript and protein expression of genes involved in cell cycle progression and apoptosis, as
well as canonical PI3K/Akt/NF-κB signaling pathways, were analyzed by qRT-PCR, immunoblotting and
ELISA. Expression profiling of noncoding RNAs (ncRNAs) that influence PI3K/Akt/NF-κB signaling was
undertaken. TUNEL assay was performed using flow cytometry.

Results:
Administration of snus induced basal cell hyperplasia in the rat forestomach with increased cell proliferation
and inhibition of apoptosis. This was associated with the activation of PI3K/Akt/NFκB signaling. Coadministration
of blueberries significantly suppressed snus-induced hyperplasia. Analysis of the molecular mechanisms
revealed that blueberries suppress the phosphorylation of Akt, NF-κB and IKKβ, prevent nuclear translocation
of NF-κB and modulate the expression of microRNAs that influence PI3K/Akt/NF-κB signaling.

Conclusion:
Taken together, the results of the current study provide compelling evidence that blueberries exert
significant protective effects against snus-induced soft tissue changes in the rat forestomach epithelium mediated
by inhibiting key molecular players in the PI3K/Akt/NF-κB signaling axis. Long-term studies on the impact
of snus exposure on various cellular processes, signaling pathways, and the interplay between genetic and epigenetic
mechanisms are however warranted. The results of this investigation may contribute to the development
of protection against soft tissue changes induced by smokeless tobacco in the human oral cavity.
Recent Patents Concerning the use of Nanotechnology-based Delivery Systems as Skin Penetration Enhancers
Authors: Medeiros-Neves Bruna , Nemitz Marina Cardoso , Silveira Fachel Flávia Nathiely , Teixeira Helder Ferreira 
Published: November 2019

:
Nanotechnology-based delivery systems have been considered a promising approach for
topical application, considering their characteristics of penetration into/across the skin. The present
review aimed to evaluate the recent international scenario of patents concerning the use of nanotechnology-
based delivery systems as skin penetration enhancers. A survey of recent patent documents was
conducted by using the Espacenet patent database including the terms “skin” in the title and “promot*
or enhanc* and penetrat* or absorp* or permeat*” and “nano*” with the truncation symbol (*) in the
abstract of documents. A total of 110 patents were published from 2008 to 2018, with 94 technologies
being considered. The results demonstrated an increase in innovations concerning nanotechnologybased
delivery systems as skin penetration enhancers in recent years. Most patent applicants are from
China (60.6%) and Korea (21.3%), and companies (68%) were the most prominent owners. The majority
of patent applications (76%) were intended for cosmetic purposes; the types of products and nanostructures
were also investigated. Overall results demonstrated the increased interest around the world
in patenting products involving skin permeation promotion and nanotechnology for pharmaceutical
and, mainly, for cosmetics purposes.
Graduates’ perception on the importance of special job market in state vocational high schools in Langsa City
Authors: Fatahillah Al , Triyono Mochamad Bruri 
Published: November 2019

This study aims to determine the perceptions of graduates of state vocational high schools in Langsa City on the performance of Special Job Market in vocational high schools based on the aspects of (1) Special Job Market performance; (2) role of Special Job Market; (3) Special Job Market service; and (4) the success of the Special Job Market. This study is quantitative research employing a descriptive approach. The population of the research is 365 graduates tracked through the Special Job Market of four vocational schools in Langsa City in 2007/2008. From the population, 15% were taken for the samples of the study, so the number of respondents is 55 graduates. The result of the research shows that: (1) the percentage of Special Job Market performance aspect is 58.54% with “quite satisfied” criteria; (2) the percentage of role of Special Job Market aspect is 59.14% with “quite satisfied” criteria; (3) the percentage of Special Job Market service aspect is 51.02% with “quite satisfied” criteria; and (4) the percentage of the success of the Special Job Market aspect is 51.17% with “quite satisfied” criteria.
Identifying Needy Students for University-Industry Snapfeed Program
Authors: Abd Razak Norfadzilah , Hashim Rugayah , Mohd Aminuddin Zaidi , Ismail Zuraidah 
Published: November 2019

This paper aims to provide empirical evidence on the university students’ nutritional habits and peer pressure on food purchases. In addition, the motivations for the study were the media highlights on poverty among public university students that led to hunger. A survey was conducted with a sample size of 1,000 students; the response rate was 80%. The findings revealed the dietary patterns from money spent on food. Cross-tabulation between family income and the number of daily meals per day showed that students coming from a low-income background have satisfactory nutritional habits, but lack of money meant lesser meals or food insecurity. Hence, a snapfeed program for low-income student to assist with daily food intake was suggested. Keywords: Needy students; poverty; dietary habits; food insecurity eISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1900
Burnout and Coping Skills amongst Medical Officers: A study in a tertiary hospital in Malaysia
Authors: Ali Nur Faizah , Nasution Raduan Nor Jannah , Ismail Zaliha , Razali Salmi 
Published: November 2019

Burnout among doctors is hazardous, leading to stress which results in poor decision making and exposure to medical errors. This study aims to improve the knowledge gap of the issues of burnout and coping skills among medical officers. This study is a cross-sectional study involving 250 medical officers, using universal sampling. Of the total 250 participants, 63 (25.2%) were burnout. The presence of burnout was significantly associated with dysfunctional coping skills (t=-4.96; p <0.001). Burnout is prevalent among medical officers. It is vital to take actions that can promote good mental health in the form of coping skills and resilience training.Keywords: burnout; coping skills; doctors; medicaleISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1940
Sale and Leaseback Investment Concepts in Malaysian REIT Companies
Authors: Johaimi Ling Nur Lesya Firsya , Haffiz Aliasak Mohd Hasrol , Alauddin Kartina 
Published: November 2019

Sale and leaseback investment has been a growing trend among the Real Estate Investment Trust (REIT) Companies in Malaysia. This study is to determine the important elements in the concepts of the sale and leaseback transactions practiced by the REIT companies. The study uses the NVIVO software to analyze the data interviews with the REIT managers that adopt sale and leaseback investment transactions. With a response rate of 78%, results show there are three main elements namely location, type of lease, and rental. This study forms a useful guide to real estate managers in developing countries towards using the sale and leaseback as one of the alternative methods in property investment.Keywords: sale and leaseback; property investment; REITeISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1942
Expression of Political Friends AhokVoluntarism in Elections Jakarta 2017
Authors: Taqwa Iradhad 
Published: November 2019

Volunteer group is one of the associations of community's political articulation in the electoral moment. By campaigning independence, non-partisan in nature, and moving in a collective way are proven able to make the volunteer group as an alternative actor and significant political force in mobilizing support and voice. Volunteer group Teman Ahok (Friends of Ahok) is a movement that openly declared itself as the political volunteer with political aims as an additional element in the winning of candidate pair Basuki Tjahaya Purnama (BTP) and Djarot Saiful Hidayat in the 2017 Jakarta gubernatorial election. The appearance of Teman Ahok in the political arena of the 2017 Jakarta gubernatorial election is related to the BTP's populism figure. Quick changes in political escalation force Teman Ahok to change its position and political role. That fluctuation brings an important dynamic to the Teman Ahok journey. It is interesting to observe Teman Ahok activity in compile community participant and then aggregate it since it causes a public perception that is diametrically opposed at a time; supporting & not supporting. This writing will analyze the expression of Teman Ahok political voluntarism and will assess the significant benefit resulted in during the process of electoral democracy.
THE IMPLEMENTATION OF LEARNING STRATEGY THROUGH QUESTION STUDENT HAVE (QSH) AT VOCATIONAL SCHOOL IN BANDUNG REGENCY
Authors: Nurwahyudin Dindin Syarif , Maulana Agung 
Published: November 2019

Learning Math needs stages which is in line with mental development as well as cognitive aspect. The point of view in this implication through learning math is to encourage awareness, produce questions, able to oppose, able to predict, appreciate to the own valuable invention, encourage students to find out math stucture and design, and encourage to think critically. Moreover, students are encouraged to analize with their assumption with credible sources, find out whether the sources are credible or not, identify and evaluate, try to implement some strategies to make the correct decision based on available assessment. One of learning stages which is offered is active learning strategy. One of the application is QSH (Question Student Have) strategy. With this method, the achievement and improvement of Mathematical critical thinking of vocational school students. Furthermore, students can easily solve their problems in (a) simplifying square root, (b) deciding sinus, cosinus, and Tangen angles, and (c) phytagoras concept.
The Role of Problem Based Learning on Improving Students’ Mathematical Critical Thinking Ability and Self-Regulated Learning
Authors: Retnaningsih Musriana , Sugandi Asep Ikin 
Published: November 2019

This study is a pre test-post test experimental control group design having a goal to analyze the role of problem based learning on students’ mathematical critical thinking ability and self regulated learning. The study involved 60 eighth grade students of an MTs, a mathematical critical thinkng test, and a mathematical self regulated learning scale. The study found that on mathematical critical thinking ability, its gain, and on mathematical self regulated learning, students getting treatment with problem based learning approach attained better grade than that of students taught by conventional teaching. The first group students obtained at fairly good grades level, while the students taught by conventional teaching attained at medium grades level. The other findings, there was fairly good association between mathematical critical thinking ability and mathematical self regulated learning.
THE EFFORTS TO IMPROVE LEARNING OUTCOMES ON LINEAR EQUATION SYSTEMS THREE VARIABLES BY USING POWER POINT MEDIA
Authors: Afgani Niki Ari 
Published: November 2019

In Learning System of Three Variable Linear Equation System Mathematics class X of Integrated High School Ar-Risalah still many under KKM (KKM 60) especially in solving the problems. Therefore, it is necessary an effort to improve the learning outcomes of Mathematics is through the media power point. This study aims to determine the improvement of learning outcomes of students class X IPA of Integrated High School Ar-Risalah academic of year 2017/2018 in the problems solving on the subject of SPLTV through power point media. The subjects of the study were the students class X IPA of Integrated high school Ar-Risalah of 22 students, a Mathematics teacher and 4 observers. Data collected included student learning outcomes, teacher observation results, student observation results. This research is a Classroom Action Research conducted in three cycles. Each cycle includes are 4 (four) stages of planning, action implementation, observation (observation) and reflection. The average value of test results cycle II, 53.18 increased by 30.49 compared to the average value of the results of the test cycle I, namely 22.69. And the average value of the third cycle test results that is 70.80 increased by 17.62 compared to the average value of the second cycle test results. Based on the performance indicator, in conclusion, that the result of the study, the students of Integrated High School Ar-Risalah on SPLTV can be improved through power point media.
COMPARISON OF THE ABILITY OF MATHEMATICAL REASONING OF SMK STUDENTS USING A METACOGNITIVE SKILL APPROACH THROUGH ADVANCE ORGANIZER LEARNING MODELS WITH A SAINTIFIC APPROACH THROUGH DISCOVERY LEARNING
Authors: Rolina Rosalina , Aryani Sri , Taufiqurrohman Erik 
Published: November 2019

This research is motivated by the low level of mathematical reasoning ability students. This study aims to determine the comparison of mathematical reasoning abilities students between those who learn using the metacognitive skills approach through advance organizer and the scientific approach through discovery learning. The method is an experimental method with a pretest-posttest control group design involving two groups and random sampling. At the beginning and end of learning, the two classes are given a test. The population in this study were State Vocational High School students in Cimahi, while the sample consisted of two randomly selected classes. Obtained class XI TEK A which was given a metacognitive skill approach through advanced organizer and class XI TOI A is given a scientific approach through discovery learning. The instrument used was a 5-item mathematical reasoning ability test description, then the data mathematical reasoning students were analyzed with descriptive and inferential statistics using the help of SPSS 21 software. Based on the results of the study, it was concluded that the improvement of students' mathematical reasoning using skills the metacognitive skills approach through advance organizer is better than students who use a scientific approach through discovery learning.
THE APPLICATION OF PROBLEM SOLVING APPROACH IN IMPROVING JUNIOR HIGH SCHOOL STUDENTS’ MATHEMATICAL COMMUNICATION AND DISPOSITION SKILL
Authors: Mulyasari Imas , Rohaeti Euis Eti , Sugandi Asep Ikin 
Published: November 2019

This article is derived from the research result entitled “The Application of Problem Solving Approach in Improving Junior High School Students’ Mathematical Communication and Disposition Skill”. The research is purposed to see and analyze if there are some improvements in mathematical communication and disposition skill achievement of the students who have been treated using problem solving approach compared to the students who are still treated using conventional approach. The population of the research is all students at a junior high school in Subang regency. Out of these students, 40 students of class VIII D were chosen randomly as the experiment class, and 41 students of class VIII C have also been randomly chosen as the control class. The data in this research have then been analyzed using parametric and non-parametric statistic. The result of this analysis has shown that the achievement of experiment class students’ mathematical communication and disposition skill is better than the achievement of the control class students. The experiment class students’ mathematical disposition is also better than those of the control class. Lastly, the result also shows that there is some kind of correlation between the mathematical communication and mathematical disposition on the level of medium.
THE CORRELATION BETWEEN SELF-REGULATED LEARNING TOWARD MATH WITH MATHEMATICAL-LOGICAL THINKING SKIL
Authors: FAJARIAH AZALINA NURUL , SETIYORINI SRI RAHAYU 
Published: November 2019

The present research aims to analyze the correlation between mathematics Self regulated learning and mathematical-logical thinking skills. The design of the research is survey correlation analysis as it is suitable to validate the relation of the two quantitative variables. To retrieve the data, 60 seventh grade students of two classrooms were sampled through cluster random sampling in SMP PGRI Pameungpeuk. The instruments employed to gather the intended data were logical-mathematical intelligence test consisting of 4 questions and self regulated learning scale consisting of 25 questions. Further, the data were analyzed in a quantitative manner modeled to logical-mathematical thinking skills data and self regulated learning scale using SPSS 20. The analysis revealed that students’ mathematical Self regulated learning significantly affects students’ logical-mathematical thinking skills.
Peningkatan Pengetahuan Pengusaha Gamelan Desa Tihingan Kabupaten Klungkung
Authors: Damayanti Ni Nyoman Sri Rahayu , P. Putra I Gst. B Ngr. , Pertama I Gde Agung Wira 
Published: November 2019

Gamelan Gunadi merupakan salah satu usaha yang bergerak di bidang pembuatan gamelan. Usaha yang terletak di Kabupaten Klungkung Kecamatan Tihingan, Propnsi Bali ini membuat berbagai macam jenis gamelan seperti gong, kecek, riyong, dan masih banyak yang lainnya. Mitra ini tidak hanya menerima pesanan gamelan, namun juga menerima pesanan perbaikan gamelan yang rusak. Terdapat beberapa kendala yang dihadapi mitra ketika melaksanakan operasional usahanya yaitu keterbatasan akan pengetahuan mengenai pencatatan keuangan serta keterbatasan dalam memasarkan usahanya. Hal tersebut yang mendorong penulis untuk melaksanakan pengabdian pada mitra ini. Terdapat beberapa kegiatan yang dilakukan untuk mengatasi kendala tersebut yaitu pelatihan penyusunan catatan keuangan cash on hand dan kas pada bank, serta melakukan penyuluhan strategi marketing yang efektif dan efisien serta mudah diimplementasikan oleh mitra. Kegiatan tersebut seluruhnya telah terlaksan. Setelah pelaksanaan penyuluhan, terdapat perubahan yang dirasakan oleh mitra yaitu mitra kini sudah bisa melakukan pencatatan keuangan sederhana sehingga yang bersangkutan mengetahui aliran kas usahanya baik yang cash on hand ataupun kas pada bank. Selain itu, mitra kini telah menguasai strategi pemasaran word of mouth yang diyakini mampu memperkenalkan usahanya serta mampu meningkatkan jumlah konsumen bagi usahanya. Kata Kunci: Gamelan, Catatan Keuangan, Word of Mouth.
Teknologi Pengolahan Pakan Amoniase Pada Sapi di Desa Nggorang, Kecamatan Komodo Manggarai Barat, NTT
Authors: Ndaong Nemay , Detha Annytha , Datta Frans Umbu , Foeh Nancy , Maranatha Grace 
Published: November 2019

Desa Nggorang, Kecamatan Komodo, Maggarai Barat merupakan daerah yang cukup ideal untuk pengembangan ternak dan pemanfaatan limbah pertanian karena didukung oleh beberapa faktor antara lain daya dukung wilayah tempat sumber air yang ada dapat memenuhi air masyarakat kebutuhan sepanjang tahun dan ketersediaan limbah pertanian jerami padi. Tujuan dari pelaksanaan pelatihan pemrosesan pakan amoniase adalah untuk memaksimalkan produktivitas peternakan sapi dengan memanfaatkan ketersediaan sumber daya alam sambil memberdayakan limbah pertanian jerami padi sebagai sumber pakan utama dengan memanfaatkan teknologi pemrosesan pakan. Oleh karena itu, pelatihan teknologi pengolahan pakan jerami telah menjadi limbah pertanian terbesar di Desa Nggorang. Berdasarkan hasil kegiatan yang ada, ada peningkatan pemahaman petani yang dicapai. Dengan demikian desa Nggorang diharapkan mampu meningkatkan kemandirian masyarakat desa melalui kelompok tani mitra yang mampu mengoptimalkan produktivitas ternak melalui kemandirian dan kecukupan pakan ternak di Desa Nggorang, Kecamatan Komodo, Manggarai Barat, NTT Kata Kunci: Agrowisata, Amoniase, Nggorang, Komodo
Potential direct secondary care cost benefits of HealthyWeightHub - Virtual Hospital 2.0 digital lifestyle intervention
Authors: Väätäinen Saku , Soini Erkki , Arvonen Sirpa , Suojanen Laura , Pietiläinen Kirsi 
Published: November 2019

HealthyWeighHub (HWH) is a 12-month coaching and education service designed to help patients with obesity make permanent life changes, launched and expanded gradually in Helsinki University Hospital (HUS) Healthvillage since 2016.
We examined the direct secondary care cost benefits of HWH, measured with potential capacity freed (PCF) compared to conventional group coaching (CGC). Costs included health care, patient co-payments and travelling expenses. First, we evaluated the PCF actualized in the first two years from 2016 to 2018 in the HUS Specific Catchment Area (HUS ERVA). Then, we predicted the PCF at Finnish national level, if HWH was implemented gradually over the five years from 2018 to 2022, aimed at treating 1 % of adults with obesity annually in 2022.
HWH’s actualized PCF was €2.69 million compared to CGC in the first two years in HUS ERVA. If the patients who received CGC had been treated with HWH instead, total PCF could have been €3.71 million. At Finnish national level, providing CGC to 1 % of adults with obesity was predicted to cost €28.0 million (€5.08 per capita) annually in 2022. With HWH predicted cost was €7.31 million (€1.33 per capita), meaning an annual PCF of €20.7 million (€3.75 per capita) in 2022 and cumulative five-year PCF of €57.5 million (€10.43 per capita). Compared to CGC, HWH is estimated to enable treatment of approximately 3.8-times more patients with obesity at the same cost.
HWH can be more affordable than CGC and a potentially efficient tool to combat the obesity epidemic. Future evaluations should examine HWH’s effectiveness and impact on the indirect costs associated with weight loss and long-term illness.