bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory and Physical Characteristics of Pan Bread Fortified with Thermally Treated Split Yellow Pea (Pisum sativum L.) Flour
Authors: Fahmi Ronak , Ryland Donna , Sopiwnyk Elaine , Aliani Michel 
Published: November 2019

AbstractPulses, including peas, are a good source of protein, dietary fiber, folic acid, and iron and are reported to reduce the risk for cardiovascular disease and diabetes. However, pulse ingredients present a known challenge as they exhibit a grassy/beany off‐flavor. Heat treatment in some cases can decrease this off‐flavor. The objective of this study was to determine the effect of substitution of 20% split yellow pea (SYP) flour treated by Revtech thermal processing at 140 °C with 10% steam (RT10%) and without steam (RT0%) for wheat flour in bread on the sensory attributes, acceptability, nutrient composition, firmness, color, and pH. RT10% was more acceptable overall than bread with untreated pea flour (USYP) or RT0% as assessed by 110 consumers. Sensory attributes were defined and measured on 15‐cm line scales by an 11 member trained panel. Attributes associated with RT10% included wheaty, sweet, and yeast aromas and wheaty flavor, whereas attributes associated with USYP and RT0% were pea and nutty aroma and flavor. Although firmness and dryness were higher in RT10%, the acceptability of the bread texture was not affected. This sample contained significantly higher protein and lower carbohydrate than the wheat sample.Practical ApplicationRevtech (RT), a novel thermal process, when applied at 140 °C with steam to split yellow pea (SYP) flour successfully increased the acceptability of white pan bread fortified at 20% compared to bread fortified with RT 140 °C with no steam, and untreated SYP flours. This could be due to its association with wheaty aroma and flavor attributes rather than the pea aroma and flavor attributes of the other two breads.
Psychometric Evaluation of the Nursing Outcome “Pain: Adverse Psychological Response” in Patients With Chronic Pain
Authors: Bellido‐Vallejo José Carlos , Pancorbo‐Hidalgo Pedro Luis 
Published: November 2019

PURPOSETo culturally adapt into Spanish and validate the outcome “Pain: Adverse psychological response” (code 1306) in patients with chronic pain.METHODSA three‐stage study was conducted: (a) translation and cultural adaptation, (b) content validation, and (c) clinical validation.FINDINGSThe Spanish version of the outcome “Pain: Adverse psychological response” has high content validity ( 0.91). Fourteen indicators were organized into two factors. This version offers good reliability in both inter‐observer agreement (kappa = 0.72) and internal consistency (alpha = 0.89).CONCLUSIONSThe Spanish adaptation of “Pain: Adverse psychological response” is a reliable and valid instrument for the measurement of emotional aspects of chronic pain.IMPLICATIONS FOR NURSING PRACTICEThe Spanish adaptation of this outcome offers nurses a set of structured indicators to measure the adverse emotional impact of chronic pain.
Relational Peer Victimization Interacts With Depression Severity to Predict the Timing of Alcohol Use Initiation in Adolescent Girls
Authors: Woerner Jacqueline , Ye Feifei , Hipwell Alison E. , Chung Tammy , Sartor Carolyn E. 
Published: November 2019

BackgroundPeer victimization is consistently linked to adolescents’ alcohol use. However, the relative influence of relational and physical peer victimization on alcohol use, and timing of drinking initiation, is not well understood. In this study, we evaluate the impact of both relational and physical peer victimization on adolescent girls’ alcohol use initiation, and the extent to which depression severity moderates these associations.MethodsParticipants were 2,125 girls in the Pittsburgh Girls Study, a longitudinal community‐based study. Participants reported experiences of relational and physical peer victimization, depression severity, and alcohol use each year from ages 10 to 17. Cox proportional hazards (PH) regression analyses predicting the timing of first drink were conducted in 2 stages, testing for main effects of peer victimization in Model 1 and moderation by depression severity in Model 2.ResultsAnalyses were split at age 14 to adjust for PH violations. Model 1 results supported a main effect for relational (Hazards ratio [HR] = 1.83, CI: 1.46 to 2.28 ≤ age 13; HR = 1.23, CI: 1.05 to 1.45 ≥ age 14) but not physical victimization on timing of alcohol use onset (HR = 1.10, CI: 0.88 to 1.39). Model 2 results show that depression severity moderates the association between relational victimization and alcohol use initiation: the association between relational victimization and early alcohol use onset was stronger for lower depression severity (−1 SD HR = 2.38, CI: 1.68 to 3.39 ≤ age 13; −1 SD HR = 1.48, CI: 1.10 to 1.52 ≥ age 14).ConclusionsResults demonstrate that relational (and not physical) victimization predicts earlier drinking among adolescent girls. Relational peer victimization conferred greater risk for alcohol use initiation when depression severity was lower, whereas girls with high depression severity engaged in early alcohol use regardless of peer victimization. Results suggest that interventions focused on relational peer victimization may have spillover effects for delaying girls’ alcohol use initiation, particularly in early adolescence, when this association is most robust.
Prenatal Alcohol Exposure Alters Error Detection During Simple Arithmetic Processing: An Electroencephalography Study
Authors: Ben‐Shachar Mattan S. , Shmueli Michael , Jacobson Sandra W. , Meintjes Ernesta M. , Molteno Christopher D. , Jacobson Joseph L. , Berger Andrea 
Published: November 2019

BackgroundArithmetic is the domain of academic achievement most consistently related to prenatal alcohol exposure (PAE). Error detection, an important aspect of arithmetic processing, can be examined in a mathematical verification task. Electroencephalographic (EEG) studies using such tasks have shown bursts of synchronized theta‐band activity in response to errors. We assessed this activity for error detection in adolescents with PAE and typically developing (TD) matched controls. We predicted that the PAE group would show smaller theta bursts during error detection and weaker responses depending on the size of the error discrepancy.MethodsParticipants’ mothers were recruited during pregnancy and interviewed about their alcohol consumption using a timeline follow‐back interview. Participants were followed from infancy and diagnosed for fetal alcohol syndrome (FAS) or partial FAS (PFAS) by expert dysmorphologists. EEGs were recorded for 48 adolescents during a verification task, which required differentiation between correct/incorrect solutions to simple equations; incorrect solutions had small or large deviations from correct solutions.ResultsPerformance was good–excellent. The PAE group showed lower accuracy than the TD group: Accuracy was inversely related to diagnosis severity. The TD and heavily exposed (HE) nonsyndromal groups showed the expected differentiation in theta‐burst activity between correct/incorrect equations, but the FAS/PFAS groups did not. Degree of impairment in brain response to errors reflected severity of diagnosis: The HE group showed the same differentiation between correct/incorrect solutions as TD but failed to differentiate between levels of discrepancy; PFAS showed theta reactions only in response to large error discrepancies; and FAS did not respond to small or large discrepancies.ConclusionsArithmetical error–related theta activity is altered by PAE and can be used to distinguish between exposed and nonexposed individuals and within diagnostic groups, supporting the use of numerical and quantitative processing patterns to derive a neurocognitive profile that could facilitate diagnosis and treatment of fetal alcohol spectrum disorders.
Evaluation of selective outcome reporting and trial registration practices among addiction clinical trials
Authors: Vassar Matt , Roberts William , Cooper Craig M. , Wayant Cole , Bibens Michael 
Published: November 2019

AbstractBackground and AimsSelective outcome reporting occurs when trialists pre‐specify primary and secondary outcomes during trial planning but alter the definitions in the published report. Here, we investigate selective outcome reporting in published addiction randomized controlled trials (RCTs) and evaluate whether particular funding sources are associated with an increased likelihood of selective outcome reporting.DesignWe conducted a cross‐sectional study of published addiction clinical trials. A PubMed search was performed to identify RCTs in addiction journals from 2013 to 2017. Included studies used a randomized design to address one of the following topics: (1) drug, alcohol and tobacco addiction prevention, (2) stabilization following excessive use of a substance, (3) relapse prevention or (4) recovery maintenance.SettingSingle‐center, medical research institution.ParticipantsOur sample included 162 RCTs that were prospectively registered with a clearly defined primary outcome.MeasurementWe extracted the following items from addiction RCTs: journal, funding source, trial registry number (if included), sample size, dates of subject enrollment, whether primary and secondary outcomes were denoted, all published outcomes,P‐value for all outcomes and whether authors mentioned any deviations from the trial protocol as it related to RCT outcomes.FindingsIn total, 47 of 162 RCTs (29.0%) had at least one major discrepancy between the trial registry and published RCT. Overall, these 47 RCTs included 54 major discrepancies. The most common major discrepancy was demotion of a primary registered outcome (19/54, 35.2%). The majority of RCTs (132/162, 81.5%) were funded from public sources. Additionally, 166 RCTs were excluded from our sample because registration could not be confirmed.ConclusionsThere is evidence suggestive of selective outcome reporting in addiction randomized controlled trials (RCTs). The most common major discrepancies pertained to the primary outcome.
Prognostication accuracy of final destination in poststroke patients requiring transitional care
Authors: Iddagoda Mayura Thilanka , Inderjeeth Charles Anoopkumar , Chan Kien , Raymond Warren David 
Published: November 2019

AbstractObjectivesTransitional care program in Australia targets older patients in hospitals requiring ongoing slow‐stream restorative care prior to discharge. Poststroke patients often require extended care and are transferred to these facilities. Transitional care providers require a predicted discharge destination. The aim of this study was to assess the accuracy of this prediction.MethodologyThis study included all patients transferred to transitional care from a stroke rehabilitation unit over eight years. Information regarding the predicted final discharge destination was collected from medical records, and the actual discharge destination was obtained from the transitional care registry.ResultsFinal destination prediction was equivalent between medical and multidisciplinary teams (κ = 0.87). However, only 60% of the predictions were accurate. Subgroup analysis, as measured by the Modified Barthel Index, suggested that functional gain was a better predictor of final destination. Other characteristics, such as age, sex and type of stroke, did not demonstrate good correlation with the final destination.ConclusionFunctional improvement, that is the Modified Barthel Index, is the best predictor of final destination after transitional care.
Rapid response teams to support dementia care in Australian aged care homes: Review of the evidence
Authors: Westera Anita , Fildes David , Grootemaat Pam , Gordon Rob 
Published: November 2019

AbstractObjectivesTo identify attributes of rapid response services designed to support people with very severe and extreme responsive behaviours, otherwise known as behavioural and psychological symptoms of dementia, in aged care homes.MethodsA rapid evidence assessment was conducted to inform the evaluation of the Severe Behaviour Response Team (SBRT) service, including a targeted search of peer‐reviewed academic literature and an Internet‐based search of government, service provider, peak body and university websites.ResultsA number of localised rapid response services targeting people with similar clinical profiles were identified, but none operated on the scale of the SBRT. Five operational attributes in common were as follows: clearly defined parameters and processes; provision of clinical expertise and knowledge translation activities; person‐centred philosophy; relationship‐oriented approach to stakeholders; and generalisable and sustainable outcomes.ConclusionsThe five attributes provided a useful framework to guide the evaluation of the SBRT and clarify opportunities for continued service development.
Is androgen deprivation therapy for prostate cancer associated with cardiovascular disease? A meta‐analysis and systematic review
Authors: Liang Zhen , Zhu Jun , Chen Longlong , Xu Yawei , Yang Yongjiao , Hu Rui , Zhang Wei , Song Yuxuan , Lu Yi , Ou Ningjing , Liu Xiaoqiang 
Published: November 2019

AbstractBackgroundAndrogen deprivation therapy (ADT) is widely being applied in men who suffered from prostate cancer. Whether androgen deprivation therapy (ADT) is associated with an increased risk of developing cardiovascular‐related disease is poorly defined.ObjectivesThe aim of the present meta‐analysis is to explore the relationship between ADT and the risk of cardiac events.Materials and methodsFor this systematic review and meta‐analysis, we searched databases from inception to April 2019 for randomized controlled trials (RCT) or observational studies that reported data on ADT administration and cardiac event incidence. The connection was evaluated through estimating relative risk ratio (RR) and 95% confidence intervals (CIs).ResultsA significantly increased acute myocardial infarction (AMI) was detected in the ADT group compared with the control group (RR = 1.19, 95% confidence interval (CI), 1.02‐1.39, P < .05). A significant difference between cardiovascular disease (CVD) and ADT was also observed, with summary RR = 1.25, 95% CI, 1.11‐1.40, P < .05. Furthermore, our study also suggested ADT was not related to increased incidence of sudden cardiac death (SCD) (RR = 1.13, 95% CI, 0.92‐1.38, P = .24); AMI and CVD were not connected with the duration of ADT (AMI: RR = 1.31; 95% CI, 0.66‐2.63, P = .44, for > 5 year group; CVD: RR = 1.12, 95% CI, 0.97‐1.30, P = .12, for > 5 year group). In addition, the RR for risk of CVD was 1.28 (95% CI, 1.01‐1.62, P < .05) for men with PCa on new hormonal agents.DiscussionVarious ADT modalities have different impact on cardiovascular disease risk in different level. Long‐term application of ADT is not associated with increased risk of AMI and CVD. Both abiraterone and enzalutamide could significantly increase the incidence of cardiac events in patients who suffered from prostate cancer. Cautions and periodic cardiovascular elevation are necessary for patients before the ADT starting.ConclusionsAndrogen deprivation therapy is associated with increased risk of AMI, CHD, in contrast, this association is not detected in SCD.
Mindfulness‐Based Interventions for University Students: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials
Authors: Dawson Anna F. , Brown William W. , Anderson Joanna , Datta Bella , Donald James N. , Hong Karen , Allan Sophie , Mole Tom B. , Jones Peter B. , Galante Julieta 
Published: November 2019

BackgroundUniversity students are expressing an increased need for mental health support. Mindfulness‐based interventions (MBIs) are being integrated into university stress‐reduction programmes globally. We conducted a comprehensive systematic review and meta‐analysis of randomised controlled trials (RCTs) assessing MBI effects on university students’ mental and physical health.MethodsWe searched nine databases, including grey literature and trial registries. Two independent reviewers extracted data following a prospective public protocol.ResultsFifty‐one RCTs were included. In comparison with passive controls, and when measured shortly after intervention completion, MBIs improve distress, anxiety, depression, well‐being, rumination, and mindfulness with small to moderate effect sizes, with no benefit found for blood pressure, sleep, life satisfaction, resilience, worry, and thought suppression. Evidence for self‐compassion is inconclusive. Effects last beyond three months for distress and mindfulness, with no data on other outcomes. Compared with active control groups, MBIs significantly improve distress and state anxiety, but not mindfulness, depression, well‐being, affect, trait anxiety, or emotion regulation. Results were robust to adjustment for multiple testing, but RCTs’ risk of bias is generally high. Moderator analyses did not find differential intervention effects according to intervention duration, delivery mode, or sub‐populations.ConclusionsMBIs may be helpful to students but higher‐quality research is needed.
Estimating individualized treatment regimes from crossover designs
Authors: Nguyen Crystal T. , Luckett Daniel J. , Kahkoska Anna R. , Shearrer Grace E. , Spruijt‐Metz Donna , Davis Jaimie N. , Kosorok Michael R. 
Published: November 2019

AbstractThe field of precision medicine aims to tailor treatment based on patient‐specific factors in a reproducible way. To this end, estimating an optimal individualized treatment regime (ITR) that recommends treatment decisions based on patient characteristics to maximize the mean of a prespecified outcome is of particular interest. Several methods have been proposed for estimating an optimal ITR from clinical trial data in the parallel group setting where each subject is randomized to a single intervention. However, little work has been done in the area of estimating the optimal ITR from crossover study designs. Such designs naturally lend themselves to precision medicine since they allow for observing the response to multiple treatments for each patient. In this paper, we introduce a method for estimating the optimal ITR using data from a 2 × 2 crossover study with or without carryover effects. The proposed method is similar to policy search methods such as outcome weighted learning; however, we take advantage of the crossover design by using the difference in responses under each treatment as the observed reward. We establish Fisher and global consistency, present numerical experiments, and analyze data from a feeding trial to demonstrate the improved performance of the proposed method compared to standard methods for a parallel study design.
Monetary policy under a multiple‐tool environment
Authors: Varlik Serdar , Berument M. Hakan 
Published: November 2019

AbstractSince the 2008 global financial crisis, central banks have been using a new set of policy tools in addition to conventional tools (such as short‐term interest rates) to conduct monetary policy. This paper employs a methodology that captures 25 of these tools with a limited number of factors for Turkey. Due to a set of factors such as the high volatility of inflation, market‐friendly financial architecture and its size, Turkey provides a unique environment to capture these factors and their effects on economic performance. The three factors identified here can be categorized as interest rate, central bank foreign exchange position and liquidity. The empirical evidence reveals that these three factors affect all the economic‐state variables considered in the paper in different directions and magnitudes.
Clinical relevance of St. John's wort drug interactions revisited
Authors: Nicolussi Simon , Drewe Jürgen , Butterweck Veronika , Meyer zu Schwabedissen Henriette E. 
Published: November 2019

The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine with anti‐depressant effects, interacting with other drugs, altering their bioavailability and efficacy, were published about 20 years ago. In 2000, a pharmacokinetic interaction between SJW and cyclosporine caused acute rejection in two heart transplant patients. Since then, subsequent research has shown that SJW altered the pharmacokinetics of drugs such as digoxin, tacrolimus, indinavir, warfarin, alprazolam, simvastatin, or oral contraceptives. These interactions were caused by pregnane‐X‐receptor (PXR) activation. Preparations of SJW are potent activators of PXR and hence inducers of cytochrome P450 enzymes (most importantly CYP3A4) and P‐glycoprotein. The degree of CYP3A4 induction correlates significantly with the hyperforin content in the preparation. Twenty years after the first occurrence of clinically relevant pharmacokinetic drug interactions with SJW, this review revisits the current knowledge of the mechanisms of action and on how pharmacokinetic drug interactions with SJW could be avoided.Linked ArticlesThis article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
Assessment of vertical ridge augmentation and marginal bone loss using autogenous onlay vs inlay grafting techniques with simultaneous implant placement in the anterior maxillary esthetic zone: A randomized clinical trial
Authors: El Zahwy Mohamed , Taha Said Abd allah K. , Mounir Ragia , Mounir Mohamed 
Published: November 2019

AbstractBackgroundBony reconstruction and dental rehabilitation of patients with posttraumatic anterior maxillary alveolar defects is a very complicated procedure. The aim of this study is the assessment of vertical ridge augmentation using autogenous onlay vs inlay bone grafting techniques in the anterior maxilla.Materials and MethodsSixteen patients (40 implants) with vertically deficient anterior maxillary alveolar ridges were equally allocated into two groups; Autogenous block bone graft was harvested from the chin with simultaneous implant placement was done either onlay (control) or inlay (study). Radiographic assessment was performed preoperatively, 1 week and 6 months postoperatively. Assessment included measurements of linear changes in the vertical height on cross sectional cuts of cone beam computed tomography (CBCT) using special software. Finally, the amount of vertical gain and marginal bone loss in each group was compared to that of the other.ResultsWound healing was uneventful for all cases except three cases of the onlay group showed wound breakdown and graft loss. The mean vertical bone gain in the control group was −0.02 mm while in the study was 3.34 mm. While the mean of the crestal bone loss of the control group was 4.77 mm and that of the study group was 1.65 mm.ConclusionThe final vertical bone gain was statistically significant in the study group, so the inlay bone grafting technique with immediate implant placement could be used successfully for vertical alveolar ridge augmentation in the esthetic zone.