bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the mechanism of narrow paced QRS duration during left bundle branch area pacing? A case report
Authors: Hayashi Yusuke , Shimeno Kenji , Nakatsuji Kenichi , Naruko Takahiko 
Published: August 2020

Abstract

Background
Although left bundle branch area pacing (LBBAP) can capture the His-Purkinje conduction system and create a narrower paced QRS duration, its mechanism has not been investigated. In this case report, ventricular activation patterns were evaluated using three-dimensional electroanatomical mapping during LBBAP and right ventricular septal pacing (RVSP).

Case summary
An 81-year-old woman with sick sinus syndrome received LBBAP, followed 4 months later with atrial fibrillation ablation. We compared ventricular activation patterns during RVSP and LBBAP using a three-dimensional electro-anatomical mapping system. Paced QRS durations during RVSP and LBBAP were 163 ms and 115 ms, respectively. The activation pattern and the total left ventricular (LV) activation time were similar during RVSP and LBBAP (86 and 73 ms, respectively), despite the conduction system capture during LBBAP. The stimulus interval to the latest LV activation point during RVSP was 117 ms, and transseptal conduction time was 31 ms (117 − 86 ms).

Discussion
Although LBBAP could capture the His-Purkinje conduction system, neither ventricular activation patterns nor total activation time changed dramatically. The mechanism of narrower paced QRS duration during LBBAP compared to that during RVSP can be attributable to passing over the slow transseptal conduction.
Hepatic dysfunction induced by intestinal dysbacteriosis mainly manifests as immunologic abnormity in mice
Authors: Luo Xia , Xu Bo , Xiong Tianqin , Su Yulin , liu Chang , Ye Yuanmei , Ou Mingming , Zhou Lian 
Published: August 2020

ABSTRACT
Currently, the potential role of the alterations occurring in the liver immune system and intestinal flora in liver injury remains unknown. Our study aimed to explore the impacts of intestinal microbial barrier damage induced by ceftriaxone on liver immunity. We developed the BALB/c mice model by administering ceftriaxone. The intestinal microbial barrier damage was observed by 16S rRNA, and the pathological changes of intestines and livers were detected by H&E or transmission electron microscope. The activation of immunocytes were tested by Flow Cytometry; the expression of LPS, ALT, AST, IL-6 and TNF-α were detected by Limulus Test or ELISA. Compared to the control, the intestinal microbes significantly decreased in ceftriaxone group. Additionally, the weight of cecum contents increased, the intestinal wall became thinner and the villus in the small intestine and cecum were damaged. The expression of LPS and the ratio of liver lymphocytes were significantly increased. H&E results indicated the structures of liver arose the pathologic changes. Meanwhile, the content of serum ALT, AST, IL-6 and TNF-α increased. Collectively, our study indicates that the damages of gut microbial barrier induced by ceftriaxone prompted activation of immunocytes and release of inflammatory cytokines, which may lead to chronic inflammation in liver.
A detailed picture of a protein–carbohydrate hydrogen-bonding network revealed by NMR and MD simulations
Authors: Nestor Gustav , Ruda Alessandro , Anderson Taigh , Oscarson Stefan , Widmalm Göran , Gronenborn Angela M 
Published: August 2020

AbstractCyanovirin-N (CV-N) is a cyanobacterial lectin with antiviral activity towards HIV and several other viruses. Here, we identify mannoside hydroxyl protons that are hydrogen bonded to the protein backbone of the CV-N domain B binding site, using NMR spectroscopy. For the two carbohydrate ligands Manα(1→2)ManαOMe and Manα(1→2) Manα(1→6)ManαOMe five hydroxyl protons are involved in hydrogen-bonding networks. Comparison with previous crystallographic results revealed that four of these hydroxyl protons donate hydrogen bonds to protein backbone carbonyl oxygens in solution and in the crystal. Hydrogen bonds were not detected between the side chains of Glu41 and Arg76 with sugar hydroxyls, as previously proposed for CV-N binding of mannosides. Molecular dynamics simulations of the CV-N/Manα(1→2)Manα(1→6)ManαOMe complex confirmed the NMR-determined hydrogen-bonding network. Detailed characterization of CV-N/mannoside complexes provides a better understanding of lectin-carbohydrate interactions and opens up to the use of CV-N and similar lectins as antiviral agents.
Size-based theory for fisheries advice
Authors: Andersen K H 
Published: August 2020

AbstractFisheries science and management is founded upon the Beverton–Holt theory of fish stock demography. The theory uses age as the structuring variable; however, there are several reasons to use body size as the structuring variable. Most of the processes that affect a fish are determined by its body size rather than its age: consumption, mortality, maturation, fecundity, fish gear selectivity, etc., and measurements of body size are easy, accurate, and abundant. Here, I review size-based theory of a fish stock and compare it to classic age-based theory. I show that size- and age-based demography are equivalent representations of demography. However, size-based theory is axiomatic, which leads to a deeper theory with two advantages: predictions need fewer parameters than age-based theory and the theory connects directly to life-history traits. The connection with traits makes size-based theory particularly useful for data-poor application and facilitates evolutionary calculations. I compare age- and size-based theories for fisheries impact and stock assessments and provide a perspective on the challenges and future of single-stock theory.
Banach-Valued Multilinear Singular Integrals with Modulation Invariance
Authors: Di Plinio Francesco , Li Kangwei , Martikainen Henri , Vuorinen Emil 
Published: August 2020

Abstract
We prove that the class of trilinear multiplier forms with singularity over a one-dimensional subspace, including the bilinear Hilbert transform, admits bounded $L^p$-extension to triples of intermediate $\operatorname{UMD}$ spaces. No other assumption, for instance of Rademacher maximal function type, is made on the triple of $\operatorname{UMD}$ spaces. Among the novelties in our analysis is an extension of the phase-space projection technique to the $\textrm{UMD}$-valued setting. This is then employed to obtain appropriate single-tree estimates by appealing to the $\textrm{UMD}$-valued bound for bilinear Calderón–Zygmund operators recently obtained by the same authors.
Key role of the motor protein Kinesin 13B in the activity of homeodomain-leucine zipper I transcription factors
Authors: Miguel Virginia Natali , Ribichich Karina Fabiana , Giacomelli Jorge Ignacio , Chan Raquel Lia 
Published: August 2020

Abstract
The sunflower (Helianthus annuus) homeodomain-leucine zipper I transcription factor HaHB11 conferred differential phenotypic features when it was expressed in Arabidopsis, alfalfa, and maize plants. Such differences were increased biomass, seed yield, and tolerance to flooding. To elucidate the molecular mechanisms leading to such traits and identify HaHB11-interacting proteins, a yeast two-hybrid screening of an Arabidopsis cDNA library was carried out using HaHB11 as bait. The sole protein identified with high confidence as interacting with HaHB11 was Kinesin 13B. The interaction was confirmed by bimolecular fluorescence complementation and by yeast two-hybrid assay. Kinesin 13B also interacted with AtHB7, the Arabidopsis closest ortholog of HaHB11. Histochemical analyses revealed an overlap between the expression patterns of the three genes in hypocotyls, apical meristems, young leaves, vascular tissue, axillary buds, cauline leaves, and cauline leaf nodes at different developmental stages. AtKinesin 13B mutants did not exhibit a differential phenotype when compared with controls; however, both HaHB11 and AtHB7 overexpressor plants lost, partially or totally, their differential phenotypic characteristics when crossed with such mutants. Altogether, the results indicated that Kinesin 13B is essential for the homeodomain-leucine zipper transcription factors I to exert their functions, probably via regulation of the intracellular distribution of these transcription factors by the motor protein.
Using Gaia DR2 to solve differential colour refraction and charge transfer efficiency issues
Authors: Lin F R , Peng Q Y , Zheng Z J 
Published: August 2020

ABSTRACT
The Gaia DR2 catalogue released in 2018 gives information about more than one billion stars, including their extremely precise positions that are not affected by the atmosphere, as well as the magnitudes in the G, RP, and BP passbands. This information provides great potential for the improvement of the ground-based astrometry. Based on Gaia DR2, we present a convenient method to calibrate the differential colour refraction (DCR). This method only requires observations with dozens of stars taken through a selected filter. Applying this method to the reduction of observations captured through different filters by the 1- and 2.4-m telescopes at Yunnan Observatory, the results show that the mean of the residuals between observed and computed positions (O − C) after DCR correction is significantly reduced. For our observations taken through an N (null) filter, the median of the mean (O − C) for well-exposed stars (about 15 G-mag) decreases from 19 to 3 mas, thus achieving better accuracy, i.e. mean (O − C). Another issue correlated is a systematic error caused by the poor charge transfer efficiency (CTE) when a CCD frame is read out. This systematic error is significant for some of the observations captured by the 1-m telescope at Yunnan Observatory. Using a sigmoidal function to fit and correct the mean (O − C), a systematic error up to 30 mas can be eliminated.
Is water ice an efficient facilitator for dust coagulation?
Authors: Kimura Hiroshi , Wada Koji , Kobayashi Hiroshi , Senshu Hiroki , Hirai Takayuki , Yoshida Fumi , Kobayashi Masanori , Hong Peng K , Arai Tomoko , Ishibashi Ko , Yamada Manabu 
Published: August 2020

ABSTRACT
Beyond the snow line of protoplanetary discs and inside the dense core of molecular clouds, the temperature of gas is low enough for water vapour to condense into amorphous ices on the surface of pre-existing refractory dust particles. Recent numerical simulations and laboratory experiments suggest that condensation of the vapour promotes dust coagulation in such a cold region. However, in the numerical simulations, cohesion of refractory materials is often underestimated, while in the laboratory experiments, water vapour collides with surfaces at more frequent intervals compared to the real conditions. Therefore, to re-examine the role of water ice in dust coagulation, we carry out systematic investigation of available data on coagulation of water-ice particles by making full use of appropriate theories in contact mechanics and tribology. We find that the majority of experimental data are reasonably well explained by lubrication theories, owing to the presence of a quasi-liquid layer (QLL). Only exceptions are the results of dynamic collisions between particles at low temperatures, which are, instead, consistent with the JKR theory, because QLLs are too thin to dissipate their kinetic energies. By considering the vacuum conditions in protoplanetary discs and molecular clouds, the formation of amorphous water ice on the surface of refractory particles does not necessarily aid their collisional growth as currently expected. While crystallization of water ice around but outside the snow line eases coagulation of ice-coated particles, sublimation of water ice inside the snow line is deemed to facilitate coagulation of bare refractory particles.
Analytic properties of the electromagnetic field of binary compact stars and electromagnetic precursors to gravitational waves
Authors: Wada Tomoki , Shibata Masaru , Ioka Kunihito 
Published: August 2020

Abstract
We analytically study the properties of the electromagnetic field in the vacuum around close binary compact stars containing at least one neutron star. We show that the orbital motion of the neutron star induces high multipole modes of the electromagnetic field just before the merger. These modes are superimposed to form a spiral arm configuration, and its edge is found to be a likely site for magnetic reconnection. These modes also enhance the total Poynting flux from neutron star binaries by a factor of 2–4. We also indicate that the electric field induced by the orbital motion leads to a magnetosphere around binaries and estimate its plasma density, which has a different parameter dependence than the Goldreich–Julian density. With these properties, we discuss possible electromagnetic counterparts to gravitational wave events, and identify radio precursors, such as fast radio bursts, as the most promising observational targets.
Long non-coding RNA expression profiles in neutrophils revealed potential biomarker for prediction of renal involvement in SLE patients
Authors: Cai Bin , Cai Jingyi , Yin Zhihua , Jiang Xiaoyue , Yao Chao , Ma Jianyang , Xue Zhixin , Miao Ping , Xiao Qingqing , Cheng Yijun , Qin Jialin , Guo Qiang , Shen Nan , Ye Zhizhong , Qu Bo , Ding Huihua 
Published: August 2020

Abstract

Objective
The long non-coding RNA plays an important role in inflammation and autoimmune diseases. The aim of this study is to screen and identify abnormally expressed lncRNAs in peripheral blood neutrophils of SLE patients as novel biomarkers and to explore the relationship between lncRNAs levels and clinical features, disease activity and organ damage.

Methods
RNA-seq technology was used to screen differentially expressed lncRNAs in neutrophils from SLE patients and healthy donors. Based on the results of screening, candidate lncRNA levels in neutrophils of 88 SLE patients, 35 other connective disease controls, and 78 healthy controls were qualified by real-time quantitative polymerase chain reaction.

Results
LncRNA expression profiling revealed 360 up-regulated lncRNAs and 224 down-regulated lncRNAs in neutrophils of SLE patients when compared with healthy controls. qPCR assay validated that the expression of Lnc-FOSB-1:1 was significantly decreased in neutrophils of SLE patients when compared with other CTD patients or healthy controls. It correlated negatively with SLE Disease Activity Index 2000 (SLEDAI-2K) score (r = −0.541, P &lt; 0.001) and IFN scores (r = −0.337, P = 0.001). More importantly, decreased Lnc-FOSB-1:1 expression was associated with lupus nephritis. Lower baseline Lnc-FOSB-1:1 level was associated with higher risk of future renal involvement (within an average of 2.6 years) in patients without renal disease at baseline (P = 0.019).

Conclusion
LncRNA expression profile in neutrophils of SLE patients revealed differentially expressed lncRNAs. Validation study on Lnc-FOSB-1:1 suggest that it is a potential biomarker for prediction of near future renal involvement.
Return to College After a First Episode of Psychosis
Authors: Shinn Ann K , Cawkwell Philip B , Bolton Kirsten , Healy Brian C , Karmacharya Rakesh , Yip Agustin G , Öngür Dost , Pinder-Amaker Stephanie 
Published: August 2020

Abstract
A first episode of psychosis (FEP) can derail a patient’s educational goals, including attainment of a college education, and this can have lasting ramifications for socioeconomic and health outcomes. Despite this, few studies have examined return to college, which is an important index of real-world educational success after a FEP. In this study, we conducted a longitudinal medical record review of patients in a transdiagnostic outpatient FEP program and performed survival analysis, setting return to college as the endpoint, among the subset of patients whose college education was interrupted. We found that 82% (93/114) of college-enrolled FEP individuals experienced disruptions to their education after FEP, but that return to college also occurred in a substantial proportion (49/88, 56%) among those on leave who had follow-up data. In this sample, the median time to college return was 18 months. When separated by baseline diagnostic category, FEP patients with affective psychotic disorders (FEAP, n = 45) showed faster time to college return than those with primary psychotic disorders (FEPP, n = 43) (median 12 vs 24 mo; P = .024, unadjusted). When adjusted for having no more than 1 psychiatric hospitalization at intake and absence of cannabis use in the 6 months prior to intake (which were also significant predictors), differences by diagnostic category were more significant (hazard ratio 2.66, 95% CI 1.43–4.94, P = .002). Participation in education is an important outcome for stakeholders, and students with FEP can be successful in accomplishing this goal.
Rival views of economic competition
Authors: Ergen Timur , Kohl Sebastian 
Published: August 2020

Abstract
Competition is a constitutive feature of capitalist societies. Social conflicts over the introduction, abolition and regulation of market organization are saturated with implicit moral arguments concerning the desirability of competition. Yet, unlike private property, exchange relations and social inequalities, economic competition has rarely been the explicit core of moral debates over capitalism. Drawing on a broad variety of social science literature, this article reconstructs, maps and systematizes ethical arguments about economic competition in capitalist societies. We discuss six contradictory rival views of economic competition and illustrate their influence by providing historical examples of the respective views in action in political-economic debates. This article serves as a mapping groundwork for reviving the systematic ethical debate on economic competition. In addition, our map of rival views lends itself to use as a structuring tool in empirical research on the moral economy and ideational embeddedness of capitalist societies, markets and firms.
2021 Young Investigator Award Winner: Anatomic Gradients in the Microbiology of Spinal Fusion Surgical Site Infection and Resistance to Surgical Antimicrobial Prophylaxis
Authors: Long Dustin R. , Bryson-Cahn Chloe , Pergamit Ronald , Tavolaro Celeste , Saigal Rajiv , Chan Jeannie D. , Lynch John B. 
Published: August 2020

Study Design.
Retrospective hospital-registry study.

Objective.
To characterize the microbial epidemiology of surgical site infection (SSI) in spinal fusion surgery and the burden of resistance to standard surgical antibiotic prophylaxis.

Summary of Background Data.
SSI persists as a leading complication of spinal fusion surgery despite the growth of enhanced recovery programs and improvements in other measures of surgical quality. Improved understandings of SSI microbiology and common mechanisms of failure for current prevention strategies are required to inform the development of novel approaches to prevention relevant to modern surgical practice.

Methods.
Spinal fusion cases performed at a single referral center between January 2011 and June 2019 were reviewed and SSI cases meeting National Healthcare Safety Network criteria were identified. Using microbiologic and procedural data from each case, we analyzed the anatomic distribution of pathogens, their differential time to presentation, and correlation with methicillin-resistant Staphylococcus aureus screening results. Susceptibility of isolates cultured from each infection were compared with the spectrum of surgical antibiotic prophylaxis administered during the index procedure on a per-case basis. Susceptibility to alternate prophylactic agents was also modeled.

Results.
Among 6727 cases, 351 infections occurred within 90 days. An anatomic gradient in the microbiology of SSI was observed across the length of the back, transitioning from cutaneous (gram-positive) flora in the cervical spine to enteric (gram-negative/anaerobic) flora in the lumbosacral region (correlation coefficient 0.94, P < 0.001). The majority (57.5%) of infections were resistant to the prophylaxis administered during the procedure. Cephalosporin-resistant gram-negative infection was common at lumbosacral levels and undetected methicillin-resistance was common at cervical levels.

Conclusion.
Individualized infection prevention strategies tailored to operative level are needed in spine surgery. Endogenous wound contamination with enteric flora may be a common mechanism of infection in lumbosacral fusion. Novel approaches to prophylaxis and prevention should be prioritized in this population.

Level of Evidence: 3
INYBI: A New Tool for Self-Myofascial Release of the Suboccipital Muscles in Patients With Chronic Non-Specific Neck Pain
Authors: Pérez-Martínez Cristina , Gogorza-Arroitaonandia Kristobal , Heredia-Rizo Alberto Marcos , Salas-González Jesús , Oliva-Pascual-Vaca Ángel 
Published: August 2020

Study Design.
A randomized, single-blinded (the outcome assessor was unaware of participants’ allocation group) controlled clinical trial.

Objective.
To investigate the effects of myofascial release therapy (MRT) over the suboccipital muscles, compared with self-MRT using a novel device, the INYBI tool, on pain-related outcomes, active cervical mobility, and vertical mouth opening, in adults with chronic non-specific neck pain (NSNP).

Summary of Background Data.
MRT is used to manage chronic musculoskeletal pain conditions, with purported positive effects. The efficacy of self-MRT, compared with MRT, has been scarcely evaluated.

Methods.
Fifty-eight participants (mean age of 34.6 ± 4.7 yrs; range 21–40 yrs; 77.6% females, 22.4% males) with persistent NSNP agreed to participate, and were equally distributed into an INYBI (n = 29) or a control group (n = 29). Both groups underwent a single 5-minutes intervention session. For participants in the control group, MRT of the suboccipital muscles was performed using the suboccipital muscle inhibition technique, while those in the INYBI group underwent a self-MRT intervention using the INYBI device. Primary measurements were taken of pain intensity (visual analogue scale), local pressure pain sensitivity, as assessed with an algometer, and active cervical range-of-movement. Secondary outcomes included pain-free vertical mouth opening. Outcomes were collected at baseline, immediately after intervention and 45 minutes later.

Results.
The analysis of variance (ANOVAs) demonstrated no significant between-groups effect for any variable (all, P > 0.05). In the within-groups comparison, all participants significantly improved pain-related outcomes, and showed similar positive changes for mouth opening. Cervical range-of-movement- mainly increased after intervention for participants in the control group.

Conclusion.
Both, MRT and self-MRT using the INYBI, are equally effective to enhance self-reported pain intensity, and local pressure pain sensitivity in chronic NSNP patients. For cervical mobility, MRT appears to be slighlty superior, compared with the INYBI, to achieve improvements in this population.

Level of Evidence: 2