bluuebunny/crossref_metadata_2025_split huggingface dataset:
Density peaks clustering based on circular partition and grid similarity
Authors: Zhao Jia , Tang Jingjing , Fan Tanghuai , Li Chenming , Xu Lizhong 
Published: November 2019

SummaryIn density peaks clustering, its complexity for computing local density and relative distance of samples raises a scalability issue for processing large datasets. To address the issue, density peaks clustering based on circular partition and grid similarity has been proposed. The algorithm partitions the data space into circular grids, with each grid treated as a sample, for determining the number of clusters and searching for the density peaks; then, a new grid similarity is calculated to effectively assign unallocated grids. The proposed circular partition method effectively reduces the number of samples and the computational complexity. Extensive experiments have been conducted on several datasets with arbitrary shapes and scales, and the proposed method outperforms other density peaks clustering variants in terms of clustering accuracy and efficiency.
PROMIS: Global Analysis of PROtein‐Metabolite Interactions
Authors: Sokolowska Ewelina M. , Schlossarek Dennis , Luzarowski Marcin , Skirycz Aleksandra 
Published: November 2019

AbstractSmall molecules are not only intermediates of metabolism, but also play important roles in signaling and in controlling cellular metabolism, growth, and development. Although a few systematic studies have been conducted, the true extent of protein–small molecule interactions in biological systems remains unknown. PROtein–metabolite interactions using size separation (PROMIS) is a method for studying protein–small molecule interactions in a non‐targeted, proteome‐ and metabolome‐wide manner. This approach uses size‐exclusion chromatography followed by proteomics and metabolomics liquid chromatography–mass spectrometry analysis of the collected fractions. Assuming that small molecules bound to proteins would co‐fractionate together, we found numerous small molecules co‐eluting with proteins, strongly suggesting the formation of stable complexes. Using PROMIS, we identified known small molecule–protein complexes, such as between enzymes and cofactors, and also found novel interactions. © 2019 The Authors.Basic Protocol 1: Preparation of native cell lysate from plant materialSupport Protocol: Bradford assay to determine protein concentrationBasic Protocol 2: Separation of molecular complexes using size‐exclusion chromatographyBasic Protocol 3: Simultaneous extraction of proteins and metabolites using single‐step extraction protocolBasic Protocol 4: Metabolomics analysisBasic Protocol 5: Proteomics analysis
Tissue‐specific tumor microenvironments influence responses to immunotherapies
Authors: Oliver Amanda J , Davey Ashleigh S , Keam Simon P , Mardiana Sherly , Chan Jack D , von Scheidt Bianca , Beavis Paul A , House Imran G , Van Audernaerde Jonas RM , Darcy Phillip K , Kershaw Michael H , Slaney Clare Y 
Published: November 2019

AbstractObjectivesInvestigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenvironment (TME) as a limiting factor of therapeutic efficacy. A determinant of TME composition is the tumor location, and clinical data have revealed associations between certain metastatic sites and reduced responses. Preclinical models to study tissue‐specific TMEs have eliminated genetic heterogeneity, but have investigated models with limited clinical relevance.MethodsWe investigated the TMEs of tumors at clinically relevant sites of metastasis (liver and lungs) and their impact on αPD‐1/αCTLA4 and trimAb (αDR5, α4‐1BB, αCD40) therapy responses in the 67NR mouse breast cancer and Renca mouse kidney cancer models.ResultsTumors grown in the lungs were resistant to both therapies whereas the same tumor lines growing in the mammary fat pad (MFP), liver or subcutaneously could be completely eradicated, despite greater tumor burden. Assessment of tumor cells and drug delivery in 67NR lung or MFP tumors revealed no differences and prompted investigation into the immune TME. Lung tumors had a more immunosuppressive TME with increased myeloid‐derived suppressor cell infiltration, decreased T cell infiltration and activation, and decreased NK cell activation. Depletion of various immune cell subsets indicated an equivalent role for NK cells and CD8+ T cells in lung tumour control. Thus, targeting T cells with αPD‐1/αCTLA4 or trimAb was not sufficient to elicit a robust antitumor response in lung tumors.ConclusionTaken together, these data demonstrate that tissue‐specific TMEs influence immunotherapy responses and highlight the importance in defining tissue‐specific response patterns in patients.
The association between mothers’ and daughters’ positive affect is moderated by child cardiac vagal regulation
Authors: Rousseau Sofie , Kritzman Lior , Frenkel Tahl I. , Levit‐Binnun Nava , Golland Yulia 
Published: November 2019

AbstractIntroductionExtensive research has supported the importance of children's positive affect in fostering prosperous psychosocial adjustment. Children's positive affect is believed to be significantly shaped by their environment in general and their caregivers’ positive affect in particular. The current study investigates the role of child cardiac vagal regulation, a psychophysiological marker for social engagement, in shaping the association between maternal positive affect and child positive affect.MethodsMothers and daughters (ndyads = 28) participated in two experimental conditions. In the non‐interactive condition, they separately drew a picture without interacting. In the cooperative condition, they drew a picture together. We measured child respiratory sinus arrhythmia (RSA), a widely used indicator of cardiac vagal regulation, during both conditions. We also coded maternal and child positive affect during the cooperative condition.ResultsMaternal positive affect was related to child positive affect, but only for children with medium‐to‐high tonic levels of RSA and RSA increases from non‐interaction to interaction.DiscussionResults suggest that child RSA plays a significant role in positive emotion socialization, by making children more susceptible to the emotional cues of their caregivers. Hence, child RSA should be taken into account in preventive and therapeutic efforts regarding child positive affect socialization.
In‐hospital ventricular arrhythmia in heart failure patients: 7 year follow‐up of the multi‐centric HEARTS registry
Authors: Alenazy Basel , Tharkar Shabana , Kashour Tarek , Alhabib Khalid Faiz , Alfaleh Hussam , Hersi Ahmad 
Published: November 2019

AbstractAimsThe aim of this study was to determine the incidence, predictors, and short‐term and long‐term outcomes associated with in‐hospital sustained ventricular tachycardia (VT) and ventricular fibrillation (VF) collectively termed ventricular arrhythmia (VA) in the heart failure (HF) patients.Methods and resultsThe HEart function Assessment Registry Trial in Saudi Arabia (HEARTS registry) is a prospective national registry of patients with chronic HF from18 tertiary care hospitals across Saudi Arabia. Diagnosis of HF was in accordance with American Heart Association/European Society of Cardiology definition criteria. The registry had enrolled 2610 HF patients during the 14 month recruitment period between October 2009 and December 2010. Occurrence of in‐hospital cardiac events, prognosis, and outcome were monitored during the 7 year follow‐up period. The incidence of in‐hospital VA in HF was 4.2%. VA was more common among men, and mean age was lesser than non‐VA patients (58.5 ± 16: 61.5 ± 15 years; P = 0.042). Smoking and family history of cardiomyopathy were significant risk factors of VA. Previous history of arrhythmia, ST elevated myocardial infarction, infections, and hypotension remained significant predictors of in‐hospital VA associated with three to seven times more risk. Patients with VA had higher rates of in‐hospital events like recurrent HF, haemodialysis, shock, sepsis, major bleeding, intra‐aortic balloon pump, and stroke compared with those without VA, all being highly significant (P < 0.001). After adjustment for age, gender, and co‐morbidities, in‐hospital VA increased the risk of cardiogenic shock by 24 times, dialysis and major bleeding by 10 times, and recurrent congestive HF and pacing by five times. Survival analysis showed that all‐cause mortality was significantly higher in the VA patients (P < 0.001). Presence of VA increased in‐hospital and 1 month mortality to 23 and 17 times, respectively.ConclusionsLower mean age of VA complicated HF patients is a matter of concern in the Saudi population. HF associated with VA increased in‐hospital events and all‐cause mortality indicating poor prognosis and survival. These findings enable risk stratification and reflect on the importance of early recognition of the clinical markers and predictors of VA prompting immediate management.
Helicene Bis(pyrazol‐1‐yl)pyridine Ligands for Luminescent Transition‐Metal Complexes
Authors: Abhervé Alexandre , Martin Kévin , Hauser Andreas , Avarvari Narcis 
Published: November 2019

AbstractInvited for the cover of this issue is Narcis Avarvari from the University of Angers, France. The cover image shows one of the helicene‐based ligands that has been designed and coordinated to transition metal ions for the preparation of luminescent complexes.
Food safety governance in China: From supervision to coregulation
Authors: Liu Zhe , Mutukumira Anthony N. , Chen Hongjun 
Published: November 2019

AbstractThe food control and regulatory system in China is beset by several challenges. While firms have to reduce their costs in pursuit of benefits, customers are increasingly focusing on safety and quality of food products. Although the Chinese government has developed more stringent regulatory measures, food safety incidents still occur, including abuse of food additives, adulterated products as well as contamination by pathogenic microorganisms, pesticides, veterinary drug residues, and heavy metals, and use of substandard materials. A national food safety strategy has been proposed to assure food safety from “farm to table.” This paper begins with the analysis of current food regulatory systems and then discusses cogovernance of food safety management in China. We explore the practice in the city of Shenzhen where government intervention has strengthened food control, thereby creating an opportunity to form a coregulatory system. The review highlights that the current food safety regulatory system of multi‐agency structure can inevitably lead to insufficient incentives for business entities. Due to asymmetric information, lack of regulatory resources, and consumer advocacy, coregulation has been developed and is increasingly being promoted as an important instrument of food regulation.
Double dissociation of learned approach–avoidance conflict processing and spatial pattern separation along the dorsoventral axis of the dentate gyrus
Authors: Yeates Dylan C. M. , Ussling Alicia , Lee Andy C. H. , Ito Rutsuko 
Published: November 2019

AbstractThe ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach–avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approach–avoidance conflict behavior by the CA3 and CA1 subfields, with inhibition of ventral CA3 increasing approach toward conflicting stimuli and inhibition of the ventral CA1 potentiating avoidance. Here, we sought to extend these findings by investigating the role of the dentate gyrus (DG), the input region of the HPC, in learned approach–avoidance conflict processing in rats. Animals were first trained to acquire three different visuotactile cue‐outcome associations in separate arms of a Y‐maze (appetitive, aversive, and neutral). Postacquisition, they were administered a “conflict test,” in which they were presented with a choice between exploring an arm in which the appetitive and aversive cues were concurrently presented (conflict stimulus), and another arm containing the neutral stimulus. GABAR‐mediated inactivation of the ventral DG, but not dorsal DG, potentiated approach behavior toward the conflict stimulus, similar to the effects of ventral CA3 inactivation. In contrast, dorsal DG, but not ventral DG, inactivation was found to impair performance on a metric spatial discrimination task, which is commonly used as a test of pattern separation. The findings of this study demonstrate a robust double dissociation between the ventral and dorsal aspects of the DG, in line with previous reports of functional differences along the longitudinal axis of the HPC.
Should accountants care about blockchain?
Authors: Fuller Stephen H. , Markelevich Ariel 
Published: November 2019

AbstractThe use of blockchain technology has increased tremendously over the last decade. Blockchain continues to evolve and new features and capabilities are developed continuously. Although the use of the technology started in cryptocurrency (specifically, Bitcoin), it has expanded to other areas that can benefit from a shared, secure, ledger. This article investigates the potential impact of blockchain technology on the accounting profession. This article analyzes data security and privacy considerations, technology, adoption, and implementation considerations, and some considerations that relate specifically to accounting and auditing. We find that the unique needs of an accounting information system may not be a good match for blockchain as it currently exists. While we explain that blockchain may deliver many benefits, particularly in the areas of data reliability and the financial statement audit, we identify several factors, which raise significant questions about whether blockchain will ever be significantly integrated in the accounting function. Chief among those concerns is the scalability of the technology at an acceptable cost. While significant investment has and will be made for further development of blockchain business applications, it is our assessment that proponents of blockchain integration in accounting have not yet made the economic case for it. We also have significant concerns about whether blockchain technology can adequately address risks associated with data security and privacy. Addressing all these issues will be a minimum requirement for gaining widespread acceptance by firms and their accountants.
Novel missense alteration in LRP4 gene underlies Cenani–Lenz syndactyly syndrome in a consanguineous family
Authors: Alrayes Nuha , Aziz Abdul , Ullah Farman , Ishfaq Muhammad , Jelani Musharraf , Wali Abdul 
Published: November 2019

AbstractBackgroundSyndactyly is a clinical feature of split‐hand foot malformation (SHFM), ectodermal‐dysplasia‐syndactyly (EDSS1) and Cenani–Lenz syndactyly syndromes (CLSS). In EDSS1, only cutaneous syndactyly is observed, with sparse hair, abnormal nails and dentition. In SHFM, bony syndactyly may vary from hypoplasia of one phalanx to aplasia of central digits, extending to complete fusion of all fingers and toes in CLSS. Several genes have been assigned to these syndromes. Performing a single step molecular diagnostics becomes a challenge when a phenotype has overlaps with several syndromes or when some of the clinical features are not fully expressed in patients.MethodsWhole exome sequencing (WES) analysis on one sample derived from a consanguineous family was performed. A causative variant in WES data was prioritized via standard bioinformatics tools. The selected variant was Sanger sequenced in all the available family members for autosomal recessive segregation.ResultsA novel missense variant (c.1151A>G; p.Tyr384Cys) was identified in the LRP4 gene. Sanger validation confirmed that all affected individuals were homozygous and the obligate carriers were heterozygous for this variant. The variant is neither reported in 1000 human genomes, nor in 60 706 exomes databases, and is predicted as “pathogenic” by SIFT, Polyphen‐2 and MutationTaster software.ConclusionsThe present study broadens the pathogenic spectrum of the LRP4 gene in syndactyly syndromes. WES is a powerful tool for genetic analysis in research and can be readily used as a first‐line diagnostic test in syndactyly and related phenotypes.
Epidemiologic features of children with Epstein‐Barr virus associated diseases in Hangzhou, China
Authors: Shi Jianrong , Ma Wangqian , Li Wei 
Published: November 2019

AbstractEpstein‐Barr virus (EBV) infection is the causative agent of multiple diseases. EBV DNA in blood is a useful diagnostic marker of primary EBV infection and reactivation. This study aimed to provide epidemiological information on children with EBV‐associated diseases identified by positive EBV DNA in Hangzhou, a city in East China. All children admitted to the Children's Hospital of Zhejiang University School of Medicine from 2010 to 2015 with suspected EBV‐related diseases and serum EBV DNA tested by quantitative real‐time polymerase chain reaction were included. Of the 10 470 children, 1205 were determined to have positive EBV DNA, and the positive rate was 11.5%. 15.8% (973 of 6162) of the illnesses of patients aged 1 to 7 years were caused by EBV as compared to that of 6.6% (179 of 2708) of children older than 7 years (P < .01) and 3.3% (53 of 1600) of of that of infants <1 year of age (P < .01). Among positive EBV DNA patients, 80.7% of EBV infections occurred in children at the age stage of 1 to 7 years. IM was the most common EBV‐related disease, accounting for 75.7% of 581 hospitalized patients. Children aged 1 to 3 years were the age group most commonly hospitalized with EBV‐IM (32.7% of the cohort) and EBV‐hemophagocytic lymphohistiocytosis (HLH) (52.6%), while EBV‐lymphoma was more common in children over 9‐year old (58.3% of the cohort). The serum EBV‐DNA load was much higher in patients with EBV‐HLH than in patients with IM (P < .05). This is a large sample study, which revealed the epidemiological characteristics of children with EBV‐associated diseases, including age, monthly and disease distribution.
Climatology of aerosol optical depth over Eastern Europe based on 19 years (2000–2018) MODIS TERRA data
Authors: Filonchyk Mikalai , Hurynovich Volha , Yan Haowen , Zhou Liang , Gusev Andrei 
Published: November 2019

AbstractThis study investigates the spatial–temporal evolution of aerosols, their optical properties (aerosol optical depth [AOD] and ångström exponent [AE]) and the trend over a period of 19 years in the Eastern European countries. The data used for the study are from moderate‐resolution imaging spectroradiometer (MODIS) Terra Collection 6.1 aerosol products with the use of Dark Target algorithm for the period from 2000 to 2018. The satellite‐based AOD products were validated against the AERONET AOD measurements in four stations, located in different regions. The results demonstrate high coherence in the setting of high values of correlation (R = 0.8–0.9) and low values of root‐mean‐square error (RMSE [0.066–0.130]) and mean absolute error (MAE [0.048–0.067]). However, of the total amount of data from AERONET stations, only 68.9% of available data fall within expected error (EE) over land. Generally, all countries recorded a low AOD (83.2% less than 0.2) and high AE (82.5% higher than 1). Mean AOD and AE values varied from 0.17 ± 0.12 and 1.31 ± 0.27 (Russia) to 0.24 ± 0.14 and 1.31 ± 0.33 (Czech Republic). There was a gradual decrease in aerosol load in all countries, the highest tendencies of AOD reduction are observed in Czech Republic, Bulgaria, Slovakia and Hungary (by −0.0028, −0.0027, −0.0026 and −0.0025 per year), while the lowest tendencies of reduction are observed in Russia and Moldova (by −0.001 and −0.0006 per year). Seasonal averaged AOD values have maximum values in summer and minimum values in winter. We studied predominant aerosol types, which are based on AOD and AE interrelation, the results showed the predominance of clean continental and mixed aerosols over all countries of the region.
Green Synthesis, Characterization, and Properties of Acyl Lysine, Serine, Threonine, and Methionine Derived from Three Types of Natural Oils
Authors: Wang Nan , Yao Kaixin , Wang Yuzhao , Ti Jinhu , Tan Jiajing , Liu Changyao , Zhang Guiju , Wang Ce , Xu Baocai 
Published: November 2019

AbstractThe development of environmentally benign products has been the subject of growing interest in the field of surfactant chemistry. Acyl amino acid surfactants bearing lysine, serine, threonine, and methionine residues were synthesized using natural oils extracted from coconut, palm kernel, and soybean as acyl donors. The chemical structures were confirmed by high‐performance liquid chromatography (HPLC/MS) and infrared (IR) spectra. Their surface activities, ion‐specific effects, detergency, and foam properties were studied systematically. The critical micelle concentration (CMC) values depend significantly on amino acid and oil types and follow the orders: (i) Lys > Thr ≈ Ser > Met and (ii) Coconut ≈ Palm kernel > Soybean oil. Interestingly, the ion‐specific effects showing that the γCMC value decreases with increasing counterion size and hydrophobicity were observed, and the results were consistent with the famous Hofmeister series. The detergency ability of acyl amino acid surfactants is better than multiple traditional surfactants in distilled water. Although the detergency ability of our products for oil‐soiled swatches decreased significantly in hard water, this problem was solved by the C‐Lys‐Na/AES mixed system showing excellent synergistic effects. Excellent foamability and foam stability were achieved for acyl threonine and serine bearing hydroxyl groups on their headgroups, suggesting that the packing of these surfactants at the air–water interface was assisted by hydrogen bonding.
Flexible thin‐film transistors application of amorphous tin oxide‐based semiconductors
Authors: Liu Xianzhe , Ning Honglong , Zhang Xu , Deng Yuxi , Guo Dong , Wang Yiping , Wang Xiaofeng , Yuan Weijian , Yao Rihui , Peng Junbiao 
Published: November 2019

AbstractThe structural, optical, and electrical properties of Si‐doped SnO2 (STO) films were investigated in terms of their potential applications for flexible electronic devices. All STO films were amorphous with an optical transmittance of ~90%. The optical band gap was widened as the Si content increased. The Hall mobility and carrier density were improved in the SnO2 with 1 wt% Si film, which was attributed to the formation of donor states. Si (1 wt%) doped SnO2 thin‐film transistor exhibited a good device performance and good stability with a saturation mobility of 6.38 cm2/Vs, a large Ion/Ioff of 1.44 × 107, and a SS value of 0.77 V/decade. The device mobility of a‐STO TFTs at different bending radius maintained still at a high level. These results suggest that a‐STO thin films are promising for fabricating flexible TFTs.
Tourists' emotional changes and eWOM behavior on social media and integrated tourism websites
Authors: Zhou Simin , Yan Qiang , Yan Mengling , Shen Chuwen 
Published: November 2019

AbstractElectronic word of mouth (eWOM) has become increasingly important for the tourism industry. However, existing studies tend to overlook tourists' eWOM sharing behavior, especially on different platforms. This paper aims to explore the antecedents of distinct eWOM behaviors on social media platforms and integrated tourism websites. Thirty tourists with rich travel experience were invited to attend in‐depth interviews. Tourists' emotions, eWOM motivations, and platform features were explored by coding. Based on dramaturgical theory and task–technology fit theory, we discovered the ways that platform features fit with tourists' eWOM motivations, which provide important implications for destination and platform management.