bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Use of Covariance‐Based Structural Equation Modelling with Reflective Measurement in Organizational and Management Research: A Review and Recommendations for Best Practice
Authors: Zhang Mary F. , Dawson Jeremy F. , Kline Rex B. 
Published: June 2020

AbstractCovariance‐based structural equation modelling (CB‐SEM) with reflective measurement has been a popular data analysis tool in organizational and management research. Extensive studies and guidelines have been published on what constitutes its best practice. What is much less known is the extent to which CB‐SEM users in organizational and management research comprehend and adhere to the standards and principles behind this advanced analytical technique. In this study, we first devised an evaluation scheme to assess the quality of CB‐SEM performed in a study, and then utilized this scheme to examine 144 CB‐SEM studies published in 12 top organizational and management journals between 2011 and 2016. The evaluation of the published studies revealed a pressing need for more systematic and standardized approaches to planning, conducting and reporting CB‐SEM studies. We discussed the implication of the findings for future work.
Single‐fraction stereotactic ablative body radiotherapy for sternal metastases in oligometastatic breast cancer: Technique and single institution experience
Authors: Li Michelle P , Kelly Dianne , Tan Jennifer , Siva Shankar , Kron Tomas , David Steven 
Published: June 2020

AbstractIntroductionDue to size and close proximity to skin, the sternum is a complicated target for stereotactic ablative body radiotherapy (SABR). This is a retrospective case series of single‐fraction SABR to sternal metastasis in patients with oligometastatic breast cancer.MethodsBetween June 2014 and June 2018, ten breast cancer patients received 20 Gy in 1 fraction to a solitary sternal metastasis. Eligible patients had Eastern Cooperative Oncology Group performance status of 0–2, oligometastatic disease (defined as 1–5 metastases) and a controlled primary site. Patients were treated with 3‐dimensional conformal radiotherapy, each patient case comprising of> 6 coplanar beams and 2–6 non‐coplanar beams. Local control, pain response and adverse events were retrospectively reviewed.ResultsThe median planned target volumes were 84.75cc (range, 14.4–197.8cc). The median conformity index was 1.29 (range, 1.2–1.49). At a median follow‐up of 32 months, nine patients achieved in‐field control. Two patients had triple negative disease, one of them developed marginal recurrence, and the other had in‐field recurrence. Seven patients had sternal pain prior to SABR, and within 3 months after SABR treatment, the pain improved (n = 3) or resolved (n = 2). Four patients developed acute grade 1 and 2 skin reactions, and two patients had late grade 1 skin reactions. There were no grade 3 or 4 toxicities.ConclusionOur case series demonstrates safety of SABR with associated disease control and analgesic benefit in selected patients with oligometastatic breast cancer. The marginal recurrence observed in this cohort suggests wider margins could be beneficial to account for microscopic disease.
A virtue ethics critique of ethical dimensions of behavioral economics
Authors: Koehn Daryl 
Published: June 2020

AbstractBehavioral economics is the latest trendy form of economics. Increasingly theorists are advocating using behavioral economics to do normative ethics or claiming that the behavioralists’ findings render normative claims otiose. I argue in this paper that we should be extremely wary when it comes to accepting any such normative pronouncements. I argue that behavioral economics: (a) minimizes and/or misunderstands the role that character and architectonic life goals play in accounting for the why of ethical behavior, (b) fundamentally misconceives human practical rationality, (c) often unduly narrows the range of human action and choice, (d) misleadingly assumes that options are merely given to us rather than generated by us in accordance with our character, (e) is parasitic upon normative ethics, (f) results in an unhelpful ad hoc approach to ethical thinking, which is unlikely to prove all that useful and may even dangerously mislead ordinary agents or those who operate corporate compliance programs and who seek to improve corporate cultures, and (g) ignores the key role played in ethical behavior by meso‐ and macro‐factors.
The loss or absence of minimal residual disease of <0·1% at any time after two cycles of consolidation chemotherapy in CBFB–MYH11‐positive acute myeloid leukaemia indicates poor prognosis
Authors: Duan Wenbing , Liu Xiaohong , Jia Jinsong , Wang Jing , Gong Lizhong , Jiang Qian , Zhao Ting , Wang Yu , Zhang Xiaohui , Xu Lanping , Zhao Xiaosu , Qin Yazhen , Shi Hongxia , Chang Yingjun , Huang Xiaojun , Jiang Hao 
Published: June 2020

SummaryNo consensus has been reached on the relationship between CBFB‐MYH11 copies and prognosis. Of 1525 acute myeloid leukemia (AML) patients, 58 with CBFB‐MYH11‐positive AML (16/58 patients with c‐kit mutation) were retrospectively analyzed with a median follow‐up duration of 29.8 (range: 4.8–74.4) months. Of these, 25/58 (43.1%) patients underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT), 10 of whom had the c‐kit mutation. Of the 33 patients who did not undergo allo‐HSCT, recurrence in patients with CBFB‐MYH11/ABL level >0.1% at any time after two consolidation cycles was significantly higher than in patients with CBFB‐MYH11/ABL level <0.1% (61.9% vs. 0%, P = 0.001); further, the 3‐year relapse‐free survival (RFS; 31.4% vs. 100%, P = 0.004) and event‐free survival (EFS; 33.1% vs. 100%, P = 0.004) were significantly decreased in patients with CBFB‐MYH11/ABL level >0.1% at any time after two consolidation cycles. The 3‐year RFS and EFS rates were lower in patients who did not receive allo‐HSCT than in those who did (31.4% vs 84.6%, P = 0.000; 31.4% vs. 80.8%, P = 0.001). CBFB‐MYH11‐positive AML patients with CBFB‐MYH11/ABL level >0.1% at any time after two cycles of consolidation had poor prognoses, and allo‐HSCT could improve their survival.
The Disappearing “Advantage of Abstract Examples in Learning Math”
Authors: Trninic Dragan , Kapur Manu , Sinha Tanmay 
Published: June 2020

AbstractWhen teaching a novel mathematical concept, should we present learners with abstract or concrete examples? In this experiment, we conduct a critical replication and extension of a well‐known study that argued for the general advantage of abstract examples (Kaminski, Sloutsky, & Heckler, 2008a). We demonstrate that theoretically motivated yet minor modifications of the learning design put this argument in question. A key finding from this study is that participants who trained with improved concrete examples performed as well as, or better than, participants who trained with abstract examples. We argue that the previously reported “advantage of abstract examples” manifested not because abstract examples are advantageous in general, but because the concrete condition employed suboptimal examples.
Narco‐Fish: Global fisheries and drug trafficking
Authors: Belhabib Dyhia , Le Billon Philippe , Wrathall David J. 
Published: June 2020

AbstractThis study analyses drug trafficking associated with fisheries around the globe. Records of vessel interdiction carried out between 2010 and 2017 suggest that the global trade of illicit drugs relies increasingly on fishing vessels. Fishery‐based trafficking is growing. A key obstacle to understanding the scope of this problem is the limited data on activities that are intentionally obscured, such as drug trafficking. Using a Fermi estimation technique for determining unknown values from limited data, we analyse 292 known cases of fishing boats engaged in drug shipment between 2010 and 2017. Results suggest that drug shipment sizes per vessel are becoming smaller over time, even as the total flow of drugs is increasing. Counter‐drug enforcement intensifies this effect, suggesting that drug trafficking networks adapt to interdiction efforts making use of smaller vessels to lower the risk of seizure. The use of fishing vessels in drug trans‐shipment has tripled over the past 8 years to about 15% of the global retail value of illicit drugs. Small‐scale fishers are at risk of turning to drug trade as an economic buffer against poverty, especially in contexts of mounting competition over declining fish stocks or strict marine conservation. At the same time, illicit capital flowing from the narcotics trade into fisheries may be driving over‐capitalization of fisheries and unsustainable resource use, ultimately to the detriment of resource‐dependent coastal communities and marine ecosystems. Future research is needed to better understand whether and how small‐scale fishermen turn to drug trade to counter livelihood risks of various kinds.
Population density, microhabitat use, and size characteristics of Pseudothelphusa dugesi, a threatened species of freshwater crab from Mexico (Brachyura: Pseudothelphusidae)
Authors: Paniagua Domínguez Emmanuel Carlos , Arce Uribe Elsah , Viveros‐Guardado Diego Alfonso 
Published: June 2020

AbstractThe brachyuran crab Pseudothelphusa dugesi, or cangrejito barranqueño, is an endangered species endemic to Cuernavaca, Morelos, in central Mexico. Individuals of P. dugesi inhabit freshwater springs, which are affected by human actions through wastewater drainage, eutrophication, exploitation, and invasive predators such as rainbow trout (Oncorhynchus mykiss). In this study, we evaluated the population density, microhabitat use, and size characteristics of P. dugesi. Sampling was conducted in May, July, and December of 2018 and March of 2019, during the dry and rainy seasons in a natural protected area, the Barranca de Chapultepec. Population density was 0.082 crabs/m2, female density was 0.052 crabs/m2, and male density was 0.112 crabs/m2; ovigerous females were not observed. Males were more abundant than females; the female: male ratio was 1:2.14. Males and females had similar carapace widths and lengths, left and right chelae lengths, and mass. Individuals of P. dugesi were found mostly under or between rocks and under leaf litter. Individuals were more active at night. An understanding of the biology and population characteristics of P. dugesi will help conservationists to develop protective measures and a conservation strategy for this endangered Mexican freshwater crab species.
A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine
Authors: von Mentzer Bengt , Russo Andrew F , Zhang Zhongming , Kuburas Adisa , Killoran Patrick M , D’Aloisio Vera , Nizic Laura , Capel Vicky , Kendall David A , Coxon Christopher R , Hutcheon Gillian A 
Published: June 2020

Abstract

Objectives
To investigate the formulation of the peptide-based antagonist (34Pro,35Phe)CGRP27–37, of the human calcitonin gene-related peptide (CGRP) receptor as a potential nasally delivered migraine treatment.

Methods
Peptide sequences were prepared using automated methods and purified by preparative HPLC. Their structure and stability were determined by LC-MS. Antagonist potency was assessed by measuring CGRP-stimulated cAMP accumulation in SK-N-MC, cells and in CHO cells overexpressing the human CGRP receptor. In vivo activity was tested in plasma protein extravasation (PPE) studies using Evans blue dye accumulation. Peptide-containing chitosan microparticles were prepared by spray drying.

Key findings
(34Pro,35Phe)CGRP27–37 exhibited a 10-fold increased affinity compared to αCGRP27–37. Administration of (34Pro,35Phe)CGRP27–37 to mice led to a significant decrease in CGRP-induced PPE confirming antagonistic properties in vivo. There was no degradation of (34Pro,35Phe)CGRP27–37 and no loss of antagonist potency during formulation and release from chitosan microparticles.

Conclusions
(34Pro,35Phe)CGRP27–37 is a potent CGRP receptor antagonist both in vitro and in vivo, and it can be formulated as a dry powder with no loss of activity indicating its potential as a nasally formulated anti-migraine medicine.
Telethonin variants found in Brugada syndrome, J‐wave pattern ECG, and ARVC reduce peak Nav1.5 currents in HEK‐293 cells
Authors: Turker Isik , Makiyama Takeru , Ueyama Takeshi , Shimizu Akihiko , Yamakawa Masaru , Chen Peng‐Sheng , Vatta Matteo , Horie Minoru , Ai Tomohiko 
Published: June 2020

AbstractBackgroundTelethonin (TCAP) is a Z‐disk protein that maintains cytoskeletal integrity and various signaling pathways in cardiomyocytes. TCAP is shown to modulate α‐subunit of the human cardiac sodium channel (hNav1.5) by direct interactions. Several TCAP variants are found in cardiomyopathies. We sought to investigate whether TCAP variants are associated with arrhythmia syndromes.MethodsMutational analyses for TCAP were performed in 303 Japanese patients with Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, and J‐wave pattern ECG. Using patch‐clamp techniques, electrophysiological characteristics of hNav1.5 were studied in HEK‐293 cells stably expressing hNav1.5 and transiently transfected with wild‐type (WT) or variant TCAP.ResultsWe identified two TCAP variants, c.145G>A:p.E49K and c.458G>A:p.R153H, in four individuals. p.E49K was found in two patients with ARVC or BrS. p.R153H was found in two patients with BrS or J‐wave pattern ECG. No patient had variant hNav1.5. Patch‐clamp experiments demonstrated that peak sodium currents were significantly reduced in cells expressing p.R153H and p.E49K compared with WT‐TCAP (66%, p.R153H; 72%, p.E49K). Voltage dependency of peak IV curve was rightward‐shifted by 5 mV in cells expressing p.E49K compared with WT‐TCAP. Voltage dependency of activation was not leftward‐shifted by p.R153H, while voltage dependency of steady‐state inactivation was leftward‐shifted by p.E49K.ConclusionsWe found two TCAP variants in the patients with BrS, J‐wave pattern ECG, and ARVC that can cause loss‐of‐function of the hNav1.5 in heterologous expression systems. Our observation suggests that these variants might impair INa and be associated with the patients’ electrophysiological phenotypes. Further studies linking our experimental data to clinical phenotypes are warranted.
Supervisory Control and Distributed Optimization of Building Energy Systems
Authors: Jiang Zhanhong , Chinde Venkatesh , Kohl Adam , Kelkar Atul G. , Sarkar Soumik 
Published: June 2020

Abstract
Energy consumption in commercial buildings is significantly affected by the performance of heating, ventilation, and air-conditioning (HVAC) systems, which are traditionally operated using centralized controllers. HVAC control requires adjusting multiple setpoints such as chilled water temperatures and supply air temperature (SAT). Supervisory control framework in a distributed setting enables optimal HVAC operation and provides scalable solutions for optimizing energy across several scales from homes to regional areas. This paper proposes a distributed optimization framework for achieving energy efficiency in large-scale building energy systems. It is highly desirable to have building management systems that are scalable, robust, flexible, and are low cost. For addressing the scalability and flexibility, a modular problem formulation is established that decouples the distributed optimization level from local thermal zone modeling level. We leverage a recently developed generalized gossip algorithm for robust distributed optimization. The supervisory controller aims at minimizing the energy input considering occupant comfort. For validating the proposed scheme, a numerical case study based on a physical testbed in the Iowa Energy Center is presented. We show that the distributed optimization methodology outperforms the typical baseline strategy, which is a rule-based controller to set a constant supply air temperature. This paper also incorporates a software architecture based on the volttron platform, developed by the Pacific Northwest National Laboratory (PNNL), for practical implementation of the proposed framework via the BACnet system. The experimental results show that the supervisory control framework proposed in this paper can save energy by approximately 11%.
Stress–Strain Relationship of Polycaprolactone in Liquid Nitrogen for Finite Element Simulation of Cryogenic Micropunching Process
Authors: Sagar Amrit , Nehme Christopher , Saigal Anil , James Thomas P. 
Published: June 2020

Abstract
In pursuit of research to create a synthetic tissue scaffold by a micropunching process, material properties of polycaprolactone (PCL) in liquid nitrogen were determined experimentally and used for finite element modeling of cryogenic micropunching process. Specimens were prepared using injection molding and tested under compression to determine the stress–strain relationship of PCL below its glass transition temperature. Cryogenic conditions were maintained by keeping the PCL specimens submerged in liquid nitrogen throughout the loading cycle. Specimens of two different aspect ratios were used for testing. Yield strength, strength coefficient, and strain hardening exponent were determined for different specimen aspect ratios and extrapolated for the case with zero diameter to length ratio. Material properties were also determined at room temperature and compared against results available in the literature. Results demonstrate that PCL behaves in a brittle manner at cryogenic temperatures with more than ten times increase in Young's modulus from its value at room temperature. The results were used to predict punching forces for the design of microscale hole punching dies and for validation of a microscale hole punching model that was created with a commercially available finite element software package, deform 3D. The three parameters, yield strength, strength coefficient, and strain hardening exponent, used in Ludwik's equation to model flow stress of PCL in deform 3D were determined to be 94.8 MPa, 210 MPa, and 0.54, respectively. The predicted peak punching force from finite element simulations matched with experimentally determined punching force results.
A Case Study on Designing a Passive Feeding-Assistive Orthosis for Arthrogryposis
Authors: Castro Miguel Nobre , Rahman Tariq , Nicholson Kristen Faith , Rasmussen John , Bai Shaoping , Andersen Michael Skipper 
Published: June 2020

Abstract
Passive arm-assistive devices play an important role in the rehabilitation of patients with neuromuscular disorders or injuries by overcoming their motor deficit. Routine human activities such as feeding are not possible without the aid provided by one of these devices or by a caregiver. In this study, a body-powered assistive device was designed for feeding purposes using a compact spherical scissors mechanism and zero-free-length (ZFL) springs (rubber bands) to leverage the patient's residual biceps and healthy triceps function. This partially balanced and lightweight orthosis was also projected to accommodate the spring attachment points closer to the elbow joint center. The performance of the prototype was evaluated on a young adult with bilateral amyoplasia of the biceps due to arthrogryposis who could not initially reach the superior anterior aspect of the close-to-torso region of the reachable three-dimensional (3D) workspace (RWS). That was accomplished by measuring the anatomical RWS of the patient before and while wearing the device. The results show that the patient, with the assistance provided by the device, was able to attain positions in the frontal close-to-torso region of the body that included reaching her mouth, thus enabling independent feeding.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits
Authors: Di Giovannantonio Matteo , Harris Benjamin HL , Zhang Ping , Kitchen-Smith Isaac , Xiong Lingyun , Sahgal Natasha , Stracquadanio Giovanni , Wallace Marsha , Blagden Sarah , Lord Simon , Harris David , Harris Adrian H.L. , Buffa Francesca M. , Bond Gareth L. 
Published: June 2020

BackgroundHeight and other anthropometric measures are consistently found to associate with differential cancer risk. However, both genetic and mechanistic insights into these epidemiological associations are notably lacking. Conversely, inherited genetic variants in tumour suppressors and oncogenes increase cancer risk, but little is known about their influence on anthropometric traits.MethodsBy integrating inherited and somatic cancer genetic data from the Genome-Wide Association Study Catalog, expression Quantitative Trait Loci databases and the Cancer Gene Census, we identify SNPs that associate with different cancer types and differential gene expression in at least one tissue type, and explore the potential pleiotropic associations of these SNPs with anthropometric traits through SNP-wise association in a cohort of 500,000 individuals.ResultsWe identify three regulatory SNPs for three important cancer genes, FANCA, MAP3K1 and TP53 that associate with both anthropometric traits and cancer risk. Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region (3'-UTR) of TP53 and both increased risk for developing non-melanomatous skin cancer (OR=1.36 (95% 1.31 to 1.41), adjusted p=7.62E−63), brain malignancy (OR=3.12 (2.22 to 4.37), adjusted p=1.43E−12) and increased standing height (adjusted p=2.18E−24, beta=0.073±0.007), lean body mass (adjusted p=8.34E−37, beta=0.073±0.005) and basal metabolic rate (adjusted p=1.13E−31, beta=0.076±0.006), thus offering a novel genetic link between these anthropometric traits and cancer risk.ConclusionOur results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.