bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of bromodomain-containing 4 in nasopharyngeal carcinoma: Clinicopathology, prognosis, immunity, and regulatory networks
Authors: Sun Zhen , Guo Xiaopeng , Feng Bao , Chen Huarong , Ling Junjun , Chang Aoshuang , Zhao Houyu , Zhuo Xianlu 
Published: December 2024

Objectives:
Nasopharyngeal carcinoma (NPC) is a highly aggressive, insidious, recurrent, and metastatic head-and-neck malignancy with a poor prognosis. Bromodomain-containing 4 (BRD4) was upregulated in various tumors and was associated with poor prognosis. Therefore, this study aimed to investigate the biological function of BRD4 in NPC and the molecular mechanisms of expression regulation.

Materials and Methods:
Based on biological big data, the expression, clinical significance, and possible biological functions of BRD4 in head-and-neck cancer were explored by bioinformatics. Then, based on a tissue microarray containing a cohort of NPC, BRD4 protein expression was detected by immunohistochemistry to explore its clinical significance and impact on prognosis.

Statistical analysis:
A p-value less than 0.05 was considered as significant.

Results:
BRD4 expression was upregulated in NPC and positively correlated with metastasis, higher tumor grades, and clinical stages, which might be positively correlated with copy number variation, CD4+ T cells, and immune checkpoint suppressor genes. Moreover, the sensitivity of cancer cells to paclitaxel and gemcitabine was negatively correlated with BRD4 expression. In addition, immunohistochemical staining showed that BRD4 was overexpressed in NPC tissues, which was correlated with lymph node metastasis and poor clinical outcomes.

Conclusions:
BRD4 is highly expressed in NPC tissues and is associated with a poor prognosis. Its aberrant expression may be closely linked to alterations in the immune microenvironment and chemotherapeutic resistance. Moreover, BRD4 is not only an oncogene in NPC but also a potential therapeutic target.
« Deviens ce que tu es »
Authors: Romano Claude 
Published: December 2024

Ce texte se propose un double objectif : 1) avancer une interprétation du célèbre vers de la deuxième Pythique de Pindare, genoi’ oios essi mathôn, en le replaçant dans le contexte de la célébration de la sagesse du souverain de Syracuse, Hiéron Ier, qui conjoint les exploits aux Jeux pythiques et olympiques et une conscience aiguë des limites de l’humain qui lui attire les bienfaits des dieux, et où la question n'est pas de "devenir soi-même", avec les accents individualistes qui s'attachent pour nous à cette expression, que de se montrer digne de ses exploits et de sa lignée, et donc conforme à ce qu'il est vraiment ; 2) examiner par quel jeu de déplacements et de transpositions cette formule a pu être traduite par Nietzsche, d'abord, par Heidegger, ensuite, par un "Deviens ce que tu es" dont l'accentuation est toute différente. Cette étude constitue ainsi une apostille à l'archéologie de l'idéal contemporain d'authenticité personnelle que l'auteur a développée dans Être soi-même (Gallimard, 2019).
Direct and indirect effects of the COVID-19 pandemic on mortality: an individual-level population-scale analysis using linked electronic health records, Wales, United Kingdom, 2016 to 2022
Authors: Owen Rhiannon K , van Oppen James D , Lyons Jane , Akbari Ashley , Davies Gareth , Torabi Fatemeh , Abrams Keith R , Lyons Ronan A 
Published: December 2024

Background
The COVID-19 pandemic resulted in increased mortality directly and indirectly associated with COVID-19.

Aim
To assess the impact of the COVID-19 pandemic on all-cause and disease-specific mortality and explore potential health inequalities associated with area-level deprivation in Wales.

Methods
Two population-based cohort studies were derived from multi-sourced, linked demographic, administrative and electronic health record data from 2016 to 2019 (n = 3,113,319) and 2020 to 2022 (n = 3,571,471). Data were analysed using generalised linear models adjusting for age, sex, area-level deprivation and time at risk.

Results
COVID-19 deaths peaked in January 2021 (54.9/100,000 person-months, 95% confidence interval (CI): 52.4–57.5). The pandemic indirectly affected deaths, with higher than expected maximum relative mortality rates (RR) related to cancer (RR: 1.24, 95% CI: 1.13–1.36), infectious diseases (excluding respiratory infections) (RR: 2.09, 95% CI: 1.27– 3.43), circulatory system (RR: 1.41, 95% CI: 1.28–1.56), trauma (RR: 2.04, 95% CI: 1.57– 2.65), digestive system (RR: 1.54, 95% CI: 1.25–1.91), nervous system (RR: 1.63; 95% CI: 1.34–2.00) and mental and behavioural disorders (RR: 1.85, 95% CI: 1.58–2.16). Mortality associated with respiratory diseases (unrelated to COVID-19) were lower than expected (minimum RR: 0.52, 95% CI: 0.45–0.60). All-cause mortality was lower in least deprived communities compared with most deprived (RR: 0.61, 95% CI: 0.60–0.62), and the magnitude of this effect increased during the pandemic.

Conclusions
All-cause and disease-specific mortality directly and indirectly associated with COVID-19 increased during the COVID-19 pandemic. Socioeconomic disparities were exacerbated during this time.
Resultados obstétricos y neonatales en embarazos logrados por fertilización asistida en una cohorte Argentina.
Authors: Diez Brito Macarena , Sevillano Gonzalo , Negri Florencia , Mongelos Milagros , Izbizky Gustavo 
Published: December 2024

Introduction: Since its introduction in clinical practice in 1981, pregnancies conceived by assisted reproductive techniques (ART) are an increasing proportion of all pregnancies, presenting particular challenges.
Objective: To analyze the maternal-fetal outcomes of pregnancies conceived by ART in a single center in Argentina.
Material and methods: Retrospective cohort of pregnancies conceived by ART who attended their delivery in a private university hospital through a review of records.
Results: The incidence of composite primary maternal outcome was 40,1% (282/703), with hypertensive disease of pregnancy (21%) being the most frequent presenting pathology.In the multivariate analysis, age > 40 (OR 2,79; 95%CI: 1,82-4,26), chronic hypertension (OR 10,59; 95% CI: 2,81-39,86), twin pregnancy (OR 8,94; 95% CI: 5,39 – 14,80) and oocyte donation (OR 1,54; 95% CI: 1,04 – 2,27) were significantly associated with the maternal primary outcome. The incidence of the composite neonatal fetal primary outcome was 56,7% (468/824), with a prematurity rate of 34,5% (252/803). In the multivariate analysis of the composite outcome of the neonatal fetus, twin pregnancy (OR 7,08; 95% CI: 3,48 – 14,39) and other complications related to prematurity were statistically significantly associated with the composite outcome.
Conclusions: Pregnancies conceived by ART show a significant increase in adverse maternal outcomes, mainly hypertension, and fetal and neonatal outcomes (prematurity, malformations, and admission to the intensive care unit).
Analisis Potensi Pergerakan Tanah Berdasarkan Ground Shear Strain Untuk Wilayah Bekasi
Authors: Rahman Aditya Setyo , Sutiyono Sutiyono , Wardaningsih Kuurnia , Istofiyah Istofiyah , Cindiwati Cindiwati , Alfiandy Solih 
Published: December 2024

Penelitian ini menganalisis nilai GSS (Ground Shear Strain) dan prediksi fenomena getaran gempa di daerah Bekasi. Hasil menunjukkan nilai GSS tergolong rendah (0,14 - 0,20), menunjukkan tingkat kerentanan rendah terhadap goncangan gempa. Pada PGA 0,22 - 0,302 g, diprediksi hanya terjadi fenomena wave vibration (getaran tanah terasa, tidak merusak). Meskipun tingkat kerentanan rendah, penting untuk tetap waspada dan melakukan mitigasi gempa bumi, seperti membangun struktur tahan gempa dan menyiapkan rencana evakuasi.
ANALISIS VARIASI SUHU PENGERINGAN TERHADAP SIFAT FISIKA DAN KIMIA TEPUNG BATANG PEPAYA (Carica papaya L.)
Authors: Ifmalinda Ifmalinda , Nasution Rizka Putri Indramora , Fahmy Khandra 
Published: December 2024

Pepaya merupakan tanaman yang digunakan sebagai sumber pangan. Tanaman pepaya yang sudah mencapai umur di atas 4 tahun akan mengalami penurunan dalam memproduksi buah dan harus ditebang untuk tanaman baru. Bahan baku industri dari batang pepaya memiliki potensi untuk dikembangkan dan dapat diolah menjdi tepung. Tepung batang pepaya dengan mutu yang baik dapat dijadikan campuran dalam pembuatan makanan ringan seperti kue dan dapat juga sebagai pengganti dari tepung terigu. Batang papaya harus dikeringkan terlebih dahulu sebelum dijadikan tepung. Hal ini bertujuan untuk mengeluarkan air yang berada dalam bahan sehingga bisa diproses lebih lanjut dan umur simpan bahan bisa diperpanjang. Tujuan dari penelitian ini adalah menentukan suhu pengeringan terbaik terhadap mutu tepung batang pepaya dengan menggunakan alat pengering tipe rak sumber panas berasal dari gas. Penelitian ini merupakan penelitian eksperimen menggunakan Rancangan Acak Lengkap (RAL) satu faktor yaitu suhu pengeringan 50ºC, 60ºC, dan 70ºC. Berdasarkan hasil penelitian, didapatkan perlakuan terbaik pada suhu pengeringan 70ºC dengan laju pengeringan 0,13877 kg/jam, dan fineness modulus (FM) 2,500.
Media and Contemporary Society: Current Trends
Authors: Suresh Kumar P.M. 
Published: December 2024

Media plays a significant role in transforming human lives. In contemporary society, it exercises considerable influence in all walks of life. The extensive spurt of print media, the proliferation of electronic, online, and digital media, and lately social media point to this. The primary function of media is information dissemination. It connects people with the surrounding world of events and happenings. In modern society where power, politics, and religion have become instruments of control media assumes significance. Media serves as an extended arm of politics. Political parties require their services to gain and stay in power or topple elected governments. Unlike other businesses, media is a dispenser of ideology. Large media houses are akin to big business ventures. Social media have been largely influenced by political activism, a quest for identity besides the propagation of ideology. One of the striking developments in contemporary society is the expanding base of religion invading other social structures. We see the world over religion has been diabolic surpassing its inherent function of worship, spiritual satisfaction, and reflection of values that make life meaningful and coexisting. In encroachment into politics, the nexus between politics and religion has thinned down. This danger results in the culmination of a religion-driven society where the dictates of religion translate into guidelines for running the government and thereby a social order based on religion. Eventually, social life and political structures are subordinated. Such a situation is dangerous where social life boils down to an entity devoid of its plurality and diversity. This paper aims to discuss the current trends in the role of media influencing contemporary society.
Antibiotic Resistance and Serotypes Distribution in Streptococcus agalactiae Bulgarian Clinical Isolates During the Years of 2021–2024
Authors: Boyanov Vasil S. , Alexandrova Alexandra S. , Hristova Preslava M. , Hitkova Hristina Y. , Gergova Raina T. 
Published: December 2024

Abstract

Streptococcus agalactiae (group B Streptococcus, GBS) is an important human and animal pathogen. In recent years, the number of streptococcal isolates resistant to antimicrobial agents has increased in many parts of the world. Various mechanisms of antimicrobial resistance and capsular serotypes of GBS with different geographical distributions can be found. A prospective cross-sectional study was conducted from September 2021 to May 2024. The survey included 257 GBS isolates from Bulgarian inpatients and outpatients with streptococcal infections. Antibiotic resistance genes and capsular serotypes were detected and evaluated using polymerase chain reaction (PCR). We classified GBS isolates into groups according to their source as vaginal samples (191) and extra-vaginal samples (66), subdivided as invasive (36) and non-invasive specimens (30). The most common serotypes were Ia (26.5%), III (20.2%), and V (19.8%). Antimicrobial susceptibility testing revealed that all examined isolates were susceptible to penicillin and vancomycin. Resistance to macrolides, lincosamides, and tetracyclines was observed in 60.3%, 24.9%, and 89.1% of the isolates. The distribution of phenotypes was cMLSb 47.4%, iMLSb 30.8%, M-type 21.2%, and L-type 0.6%. PCR analysis revealed nine genes associated with macrolide and lincosamide resistance: ermB (54.2%), ermA/TR (30.3%), mefA (20.7%), ermC (18.1%), msrD (14.8%), mefE (8.4%), IsaC (8.4%), InuB (7.7%), and IsaE (6.5%). Two genes linked to tetracycline resistance tetM (89.1%) and tetO (14.4%) were detected. Compared to the previous period, we observed increased antibiotic resistance. There was no statistical significance between the distribution of serotypes and antimicrobial non-susceptibility depending on the sample source.
Exploring the Plant Growth-Promotion Properties of Rhizospheric and Endophytic Bacteria Associated with Robinia pseudoacacia L. in Serpentine Soil
Authors: Hasanović Mujo , Hrelja Emir , Hajro Anesa Ahatović , Murtić Senad , Durmić-Pašić Adaleta 
Published: December 2024

Abstract
Serpentine soils are characterized as a unique environment with low nutrient availability and high heavy metal concentrations, often hostile to many plant species. Even though these unfavorable conditions hinder the growth of various plants, particular vegetation with different adaptive mechanisms thrives undisturbed. One of the main contributors to serpentine adaptation represents serpentine bacteria with plant growth-promoting properties that assemble delicate interactions with serpentine plants. Robinia pseudoacacia L. is an invasive but adaptive species with phytoremediation potential and demonstrates extraordinary success in this environment. To explore more in-depth the role of plant growth-promoting serpentine bacteria, we isolated them and tested their various plant growth-promoting traits both from the rhizosphere and roots of R. pseudoacacia. Based on the demonstrated plant growth-promoting traits such as siderophore production, phosphate solubilization, nitrogen fixation, indole-3-acetic acid production, and ACC deaminase production, we sequenced overall 25 isolates, 14 from the rhizosphere and 11 from the roots. Although more efficient in exhibiting plant growthpromoting traits, rhizospheric bacteria showed a low rate of diversity in comparison to endophytic bacteria. The majority of the isolates from the rhizosphere belong to Pseudomonas, while isolates from the roots exhibited higher diversity with genera Pseudomonas, Bacillus, Staphylococcus, Lysinibacillus and Brevibacterium/Peribacillus/Bacillus. The capacity of the described bacteria to produce siderophores, solubilize phosphate, and fix nitrogen highlights their central role in enhancing nutrient availability and facilitating R. pseudoacacia adaptation to serpentine soils. The findings highlight the potential significance of serpentine bacteria, particularly Pseudomonas, in contributing to the resilience and growth of R. pseudoacacia in serpentine environments.
Culture-Based Standard Methods for the Isolation of Campylobacter spp. in Food and Water
Authors: Neyaz Leena A. , Arafa Sara H. , Alsulami Fatimah S. , Ashi Hayat , Elbanna Khaled , Abulreesh Hussein H. 
Published: December 2024

Abstract

Campylobacter spp. is a major source of global gastrointestinal infections. Their enteric infections are linked to the consumption of undercooked poultry products, contaminated milk and water, and the handling of wild animals and birds. The detection of Campylobacter spp. in water and food samples mainly depends on culture-based techniques. Public Health England (PHE), the U.S. Food and Drug Administration (FDA), and the International Standard Organization (ISO) have standardized Campylobacter spp. isolation and enumeration procedures for food and water samples, which involve the usage of selective agar media and enrichment broth. Different types of selective plating and enrichment media have been prepared for Campylobacter spp. detection and assessment during regular food surveillance and food poisoning. To date, culture media remains the standard option for microbiological food analysis and has been approved by the U.S. Environmental Protection Agency (US EPA), Food and Agriculture Organization (FAO), and World Health Organization (WHO). This review discusses the standard microbiological protocols for Campylobacter spp. isolation and enumeration in food and water and evaluates detection media (pre-enrichment, selective enrichment, and selective plating) for their rational applications. Moreover, it also elaborates on the advantages and disadvantages of recent chromogenic culture media in Campylobacter spp.-oriented food surveillance. This review also highlights the challenges of culture-based techniques, future developments, and alternative methods for Campylobacter spp. detection in food and water samples.
Using p-median to solve location design problems
Authors: Shnaishel Cheetar* Alaa 
Published: December 2024

Purpose: This research mostly concentrates on guiding pupils to their secondary schools following their accomplishment in the early elementary education phase. The primary challenge is the establishment of additional schools to accommodate the significant population growth resulting from expansion in emerging areas.
Theoretical framework: Scholarly literature has thoroughly examined the P-Median problem and applied it across various domains, including cluster analysis, quantitative psychology, marketing, the communications sector, sales force design, and political constituency division.
Design/methodology/approach: This study aims to propose a customization form based on the P-Median issue, taking into account its properties and structure. The P-Median problem optimizes the allocation of the facility (student school) to the demand point (student home) based on the average distance. This tool determines the best placement for a few schools.
Findings: In this research, of the form (P-Median) and the implementation of math results, which the results showed that sites number (4,3,1) in table No. (4) and knowledge in Table No. (1), the places where schools can be created because they are the most sought -after as they are newly constructed. These new schools can also accommodate the increase in the number of students in other regions.
Research, Practical & Social implications: It is possible to study and develop the proposed model according to new data and in line with the requirements.
Originality/value: The diversity of publishing and studying novel allocation methods increases cognitive capacity, particularly for new, relevant, and helpful issues, because they are practical for distributing the service facilities the country requires.
Authors’ individual contribution: Conceptualization — A.S.C.; Methodology — A.S.C.; Formal Analysis — A.S.C.; Investigation — A.S.C.; Data Curation — A.S.C..; Writing —Original Draft — A.S.C.; Writing — Review & Editing — A.S.C.; Visualization — A.S.C.; Supervision — A.S.C.; Project Administration — A.S.C.
Declaration of conflicting interests: The Authors declare that there is no conflict of interest.
Paper type: Research Paper
Strategic Planning for Investing in Mineral Resources in Anbar Governorate Using SWOC Analysis
Authors: Firas Ata Alkubaisy* Husam , Fadel Jawad Al-Dahlaki Saja 
Published: December 2024

Purpose: The study aims to find the appropriate strategy to activate the role of mineral investment in achieving economic and social development in Anbar Governorate, and to identify the obstacles that prevent this through analyzing the internal and external environments that include strengths, weaknesses, opportunities, and challenges.
Theoretical Framework: Mineral wealth is one of the most important natural resources in our world. Its discovery and exploitation contribute to the development, growth, and advancement of economies globally, which positively impacts various aspects of economic, social, and political life. It is noteworthy that Iraq in general, and Anbar province in particular, possess a rich environment abundant in mineral resources distinguished by their quantity and economic variety.
Design/Methodology/Approach : The research relied on the inductive approach by analyzing data from official sources, as well as personal interviews with academics and officials in positions of responsibility in Anbar Governorate and directors of departments related to mining investment, and after relying on the results of the checklists in the tables included in the research (2, 3, 4, and 5) for the sample consisting of 25 people, in addition to using the strategic matrix (SWOC) to develop a future strategic plan to exploit the mineral resources available in Anbar Governorate.

Findings: The comparison of the results obtained through the strategic analysis using the SWOC method with the main research hypothesis revealed the extent of convergence between the results and the hypothesis, which suggests an abundance of mineral resources alongside obstacles hindering their exploitation. Additionally, there is a lack of a clear and specific strategy for mineral investment in the province.
Research, Practical & Social Implications: The researchers propose a future research agenda, emphasizing the necessity of conducting further studies that address the strategic analysis of natural resources in Anbar Province.
Originality/Value: The results indicate that the three strategies developmental, remedial, and defensive are difficult to implement in the province's economy, as shown by the numerical results of the SWOC matrix. The contractionary strategy appears to be the most suitable, as it applies to economies facing economic crises, that need to narrow the gap in their economic performance and rehabilitate their basic economic structure.
Hubungan Tingkat Pengetahuan Terhadap Sikap Orang dengan HIV/AIDS pada Oral Hairy Leukoplakia dan Kandidiasis Oral
Authors: Radithia Desiana , Ernawati Diah Savitri , Surboyo Meircurius Dwi Condro , Ayuningtyas Nurina Febriyanti , Mahdani Fatma Yasmin , Pratiwi Aulya Setyo , Sismiyanti Rossy , Kuntardjo Yuhanna , Puspitasari Yeni 
Published: December 2024

Pendahuluan: HIV/AIDS telah menjadi masalah kesehatan masyarakat global. Infeksi HIV dapat menyebabkan gangguan kekebalan tubuh dan bermanifestasi di beberapa tempat baik secara sistemik maupun di rongga mulut. Manifestasi oral yang paling umum terkait dengan HIV/AIDS adalah Kandidiasis Oral dan Oral Hairy Leukoplakia. Sebagai orang yang hidup dengan HIV/AIDS (ODHIV) mungkin menemukan manifestasi tersebut, pengetahuan mereka dapat menentukan sikap mereka terhadap temuan tersebut.Tujuan Penelitian: Mengamati sikap ODHIV di kota Surabaya terhadap dua manifestasi oral HIV yang paling umum ditemukan, yaitu Oral Hairy Leukoplakia dan Kandidiasis Oral, serta menentukan hubungan antara pengetahuan dan sikap mereka terhadap hal tersebut. Bahan dan Metode: Sebanyak 30 responden diberikan kuesioner untuk menilai pengetahuan dan sikap mereka mengenai Oral Hairy Leukoplakia dan Kandidiasis Oral. Pengetahuan didefinisikan dengan kriteria baik, cukup, dan rendah. Sikap didefinisikan sebagai positif, netral, dan negatif. Hasil: Tingkat pengetahuan mengenai Oral Hairy Leukoplakia dan Kandidiasis Oral menunjukkan hasil tinggi (33%), sedang (54%) dan rendah (13%). Responden menunjukkan sikap positif (30%) dan sikap tidak setuju (27%), sedangkan netral (43%). Terdapat hubungan positif yang signifikan antara tingkat pengetahuan responden dengan sikap mereka (p = 0,46). Kesimpulan: Terdapat hubungan antara pengetahuan yang baik dengan sikap positif pada masyarakat.