bluuebunny/crossref_metadata_2025_split huggingface dataset:
TURNING THE OXYGEN DIAL AS A THERAPY: HYPOXIA TREATMENT FOR MITOCHONDRIAL DYSFUNCTION
Authors: Jain Isha 
Published: November 2019

Abstract
Mitochondrial disease affects 1 in 4800 live births, with little in the way of therapies. We found that chronic hypoxia extends the life of a Complex 1 disease model by 5-fold. Starting hypoxia therapy at a late-stage of disease can even reverse the MRI-detectable lesions. At the other extreme, mild hyperoxia greatly exacerbates disease and leads to death within several days. These findings have now led to a phase 1 clinical trial in healthy volunteers, with the ultimate goal of human translation. We believe we have identified a new mode of treatment that will be broadly applicable to different forms of mitochondrial dysfunction, ranging from rare inborn errors of metabolism to more common, age-associated pathologies. We believe that “turning the oxygen dial” to low or high oxygen will serve as a novel therapeutic for a range of conditions in the coming years.
INTEGRATING FRAILTY AND COGNITIVE PHENOTYPES: THEORY, MEASUREMENT, APPLICATIONS
Authors: Xue Qianli , Buta Brian , Ma Lina , Ge Meiling , carlson Michelle 
Published: November 2019

Abstract
The fact that frailty and cognitive impairment are associated and often coexist in older adults has led to the popular view of expanding the definition of frailty to include cognitive impairment. However, there is great variability in approaches to and assumptions regarding the integrated phenotypes of physical frailty and cognitive impairment. By reviewing the theoretical underpinnings of three integrated phenotypes of physical and cognitive impairments, this talk advocates the incorporation of biological theories in phenotype development that helps determine shared and distinct pathways in the progression to physical and cognitive impairments.
PHYSICAL FRAILTY, COGNITIVE FRAILTY, AND THE RISK OF DEMENTIA IN THE GAIT AND BRAIN STUDY
Authors: Montero-Odasso Manuel , Adamson Yanina S , Muir-Hunter Susan , Doherty Tim , Casas-Herrero Alvaro , Camicioli Richard , Wells Jennie , Speechley Mark 
Published: November 2019

Abstract
Cognitive-frailty has been proposed as a distinctive entity which preludes dementia. We examined the relationship between physical frailty, cognitive status, and gait performance as predictors of cognitive decline and incident dementia. Using a cohort study of 252 community older adults free of dementia at baseline, we found that participants with frailty had a higher prevalence of cognitive impairment (77%) compared to those without (54%, p=0.02) but the risk of progression to dementia was not significant. Adding cognitive impairment to the frailty phenotype (cognitive-frailty) predicted further cognitive impairment and progression to dementia. However, when the slow gait component of frailty was combined with baseline cognitive impairment, it showed the highest risk of progression to dementia (HR: 35.9; 95%CI: 4.0–319.2; p= 0.001). Frailty and Cognitive impairment are common and co-exist in the same individuals. However, slowing gait seems to be the frailty component driving the association with future dementia.
ACCREDITATION FOR GERONTOLOGY EDUCATION COUNCIL: OVERVIEW AND EXPERIENCES TO DATE
Authors: Sterns Harvey L 
Published: November 2019

Abstract
This presentation will describe the accreditation process that was developed by a special committee under the sponsorship of the Association for Gerontology in Higher Education. With support from The Russell & Josephine Kott Memorial Charitable Trust, the committee developed materials to guide the evaluation process and an operations manual, formed a Board of Governors, registered as an independent non-profit and gained approval as a 501C3 entity. This resulted in the official formation of the Accreditation for Gerontology Education Council. Three schools have gone through the accreditation process. Results of the process will be described and lessons learned will be discussed. Refinement of the process is ongoing. There is a marketing committee that has reached out to additional schools, and new applications are being accepted.
WHANAUNGATANGA AND FILIAL PIETY: INTERGENERATIONAL EXCHANGES IN CONTEMPORARY MAORI AND KOREAN CULTURES
Authors: Park Hong-Jae , Anglem Jim 
Published: November 2019

Abstract
Every culture has its own tradition of intergenerational exchange based on accepted norms, while the meanings of traditional filial values have evolved over time. This paper aims to identify the various forms of filial care, support and respect for older people in Maori and Korean cultures, and reconceptualise current ways of intergenerational exchanges in both physical and virtual contexts. Data were collected through a qualitative inquiry framework consisting of 32 individual interviews and 5 ethnographic observations in New Zealand and South Korea. Thematic analysis of the data was used to identify themes and patterns from the participants’ perspectives and experiences in the multilingual research context. In this cross-cultural study, for Māori participants, whanaungatanga (family relationships) was recognised as a core value that places whanau (family) at the centre of whakapapa (human and non-human relations). For Korean participants, their tradition of filial piety has continued to constitute a major component of familism mindsets and practices, while their ability to support their parents and maintain connections to their ancestors varied. Being knowledgeable about the traditional values of intergenerational solidarity helped generations feel connected and supported by each other, although both monetary and non-monetary support for one’s elders has come under strain due to the impact of changes in family ties and social dynamics. Technological developments have reshaped traditional filial practices, offering new ways of intergenerational exchanges. Redefining whanaungatanga and filial piety can provide a theoretical basis for developing the concept of extended social work through avoiding excessive individualism and culture-blind approaches.
ASSESSMENT OF THE AGEC STANDARD DEMONSTRATING STUDENT LEARNING
Authors: Maiden Robert J , Abushakrah Jan 
Published: November 2019

Abstract
Addressing the gerontology program’s experience in measuring and integrating the competencies in their curricula is a fundamental challenge in program evaluation. Using the AGHE Gerontology Competencies for Undergraduate and Graduate Education is the key. We will demonstrate how one identifies the learning outcome measures across the curriculum based on the competencies by adumbrating a four-step process. First, it entails developing a written statement of the key learning outcomes, expressing them in objective, measurable terms. Second, the learning outcomes are assessed. Third, the results of the assessments are posted in a matrix format across a four or five year period. Fourth, the results of the learning outcome assessments are discussed, evaluated, and implemented in a formative process to improve teaching and learning. In addition, the results can be applied in a summative way to evaluate and improve the gerontology program.
LIVING IN RURAL CONTEXTS: TOWARD A CRITICAL INTERDISCIPLINARY PERSPECTIVE ON RURAL AGING
Authors: Walsh Kieran , Skinner Mark 
Published: November 2019

Abstract
Despite a growing focus on rural ageing, international literature in this field remains underdeveloped in critical and interdisciplinary perspectives. Reflecting traditional divisions across geographic, gerontological and health literatures, how we understand experiences of growing older in rural settings can still be characterised by a narrow, applied approach. This has implications for our capacity to disentangle multifaceted lived realities from rural contexts, and macro socio-economic and structural environments. There then remains questions about the ways in which the study of rural ageing needs to develop to direct policy, research and practice agendas to be a more critical reflection of these complexities. This symposium aims to draw together interdisciplinary critical perspectives on ageing and rurality as a means to advance this development. It will consider different theoretical approaches and major cross cutting challenges in relation to rural ageing. Burholt and Scharf will examine how critical gerontology has raised awareness of the heterogeneity of rural ageing across social justice elements of demography, resources, recognition and representation. Keogh and Walsh address these same elements in relation to the empirical intersection of exclusion and change in the production of a new rurality for older people. Cutchin and Rowles present a pragmatist theoretical perspective to encapsulate the essence of rural integration within an ever-changing milieu. Poulin et al. offer a critical approach to rural gerontological health that emphasizes intersectionality in the formation and development of older adult health. Herron and Skinner explore the intersectional construction of dementia and mental health in rural settings for older adults.
LEVERAGING CRITICAL RURAL GERONTOLOGY TO IMPROVE RURAL GERONTOLOGICAL HEALTH
Authors: Poulin Laura , Hanlon Neil 
Published: November 2019

Abstract
A critical approach in rural gerontology has led to a better understanding of the complex interplay between older adults unique aging experiences and the multidimensional and dynamic communities in which they live. The evolution of critical rural gerontology will be explored, outlining why a similar approach is needed in rural gerontological health. In particular, rural gerontological health literature must expand beyond a deficit focus that homogenizes older adult health experiences and recognize the complexities of negotiating older adult health within multidimensional rural spaces. Inherent in this approach is recognizing the intersectionality of older adult health as well as the need to study rural gerontological health as an experience enhanced and inhibited by interactions within and across formal health services, informal social services and informal care. This approach will contribute to innovations in policy and practice addressing the burgeoning interest of how to effectively care for older adults in rural settings.
EXPLORING THE CRITICAL CONTRIBUTIONS OF ARTS-BASED APPROACHES IN RURAL DEMENTIA CARE
Authors: Herron Rachel 
Published: November 2019

Abstract
People living with dementia can experience significant barriers to meaningful participation in their communities, particularly in underserviced rural and small-town settings. Drawing on a multi-method pilot study employing observations, diaries, focus groups and interviews in rural Canada, we examine the potential of an innovative dance program developed by Baycrest Health Sciences and Canada’s National Ballet School, to transform the experiences of people living with dementia and the rural places in which they live. Our findings identify moments, processes, and places of transformation throughout the program including moments of individual self-expression; changing interactions with staff, volunteers, and carers; and changing relationships with home and community. We argue that art-based programs can challenge dominant assumptions about people living with dementia and contribute to the creation of more just health and social care in rural places. In doing so, we illustrate the value of critical arts-based approaches to aging in rural places.
OPEN SCIENCE IN GERONTOLOGY: IMPLICATIONS FOR PUBLISHING
Authors: Isaacowitz Derek M 
Published: November 2019

Abstract
One big push in open science is to change journal practices to encourage a more transparent and replicable scientific record. I will start by considering why these issues are important from the perspective of a journal editor. The Transparency and Openness Promotion Guidelines were developed as a modular way for journals to encourage and/or require certain practices by authors before submitting. I will describe the TOP guidelines and will recount my experience in working to bring the Journals of Gerontology: Psychological Sciences to Level 1 of the TOP guidelines. Despite the challenges involved in changing journal practices to encourage and/or mandate greater use of open science practices, these changes will likely be coming to more journals in gerontology and beyond in the coming years, making it important for authors to be aware of changes in expectations and practices.
PREREGISTRATION TO FACILITATE A REPLICABLE SCIENCE OF AGING
Authors: Boot Walter R 
Published: November 2019

Abstract
Psychology and other sciences have been in the midst of a replication crisis. One proposal to address this crisis is the preregistration of studies, including study hypotheses, methods, measures, and analysis approaches to reduce false positive findings resulting from “experimenter degrees of freedom.” This talk will explore the benefits, and also the challenges, of preregistration, along with common misconceptions about preregistration. A preregistration case study will be presented involving a series of experiments exploring different hypotheses regarding the mechanism behind changes in attentional processing associated with aging (http://doi.org/10.1525/collabra.26). This talk will present a brief tutorial of how to preregister studies and where to preregister them. The importance of preregistration for intervention studies will be emphasized.
LAUNCHING STANDARDIZED GERIATRIC SURGERY PROGRAMS: THE ALPHA AND BETA PILOTS
Authors: Zhang Lindsey 
Published: November 2019

Abstract
Then Coalition for Quality in Geriatric Surgery has completed both alpha and beta pilots which represent the initial efforts to launch this national quality initiative to improve the care of all older adults undergoing operations. The alpha phase included hospital stakeholders rating the feasibility of implementing standards related to evidence-based high quality surgical care for older adults on the topics of eliciting patient goals, completing a preoperative frailty risk assessment, educating healthcare professional about care specific to older adults, and implementing postoperative age-friendly care models. The beta pilot phase required 9 medical centers nationally (including an academic hospital, an urban medical center, a Kaiser hospital, a VA hospital and a rural hospital) to implement the evidenced based standards for high quality surgical care of older adults. Site verification visits were completed in the Summer 2018 which evaluated the effectiveness of each medical center’s ability to implement each of the standards.
ALLEVIATING LONELINESS AT 100: IS RELIGION A SOLUTION?
Authors: Bishop Alex J , Randall Kevin 
Published: November 2019

Abstract
Data from N = 154 centenarians residing in Oklahoma were assessed using the Duke University Religious Index (DUREL). Items assessing religious salience (α=.76) were employed to create a binary measure of high (N=56 or 36.4%; M= 29.77, SD=4.65) and low (N=49 or 31.8%; M=25.10, SD=6.58) religious salience (RS). A series of ANCOVA analyses were then conducted controlling for education, race, self-reported health, and self-care capacity relative to the binary outcome RS. Significant differences for both the corrected model and the pairwise comparisons using Bonferroni adjustment emerged in favor (p ≤.001) of the high RS group (M HI =29.60; M LO=25.29) for life satisfaction and social provisions (M HI =82.43; M LO=76.62). However, the RS group was also significantly higher (p =.004) in reported loneliness (M HI =34.56; M LO=31.63). Implications of the findings for reducing loneliness among centenarians reporting high religious engagement are further highlighted.
SAFE AND EFFECTIVE PAIN CONTROL FOR GERIATRIC PATIENTS: A MULTIDISCIPLINARY APPROACH DURING THE OPIOID EPIDEMIC
Authors: Gurvich Tatyana 
Published: November 2019

Abstract
Opioid use is at a crisis level. According to the CDC, an estimated 20 % of patients presenting to physician offices with non-cancer pain receive an opioid prescription (1). According to the Administration on Aging and Substance Abuse and Mental Health Services Administration, the population of older adults who misuse opioids is expected to double by 2020. Today’s mandate to reduce opioid use and to manage patients safely with adjuvant medications comes with many challenges in geriatrics. Many patients have comorbidities which limit the use of adjuvant pain medications. A careful balance must be achieved, in order to provide good pain management and improve quality of life in this patient population. This symposium will explore multidisciplinary approaches to managing pain in geriatrics to reduce opioid use and manage safe opioid use where necessary. Pharmacological strategies for adjusting dosing and managing compliance will be discussed. Cooperative education to improve prescribing practices along with patient education to improve safe use, are important elements. Adjunct use of physical therapy and integrative medicine are also discussed as viable and effective adjuncts or alternatives to traditional pain management. You will learn how to use medications safely, utilize physical therapy to its maximum potential and learn more about innovative integrative medicine techniques, all of which decrease pain and improve function and most importantly quality of life. (1) Daubresse M, Chang HY, Yu Y, et al. Ambulatory diagnosis and treatment of nonmalignant pain in the United States, 200-2010. Med Care 2013; 51:870-8
SAFE PHARMACOLOGIC APPROACHES TO PAIN MANAGEMENT IN GERIATRIC PATIENTS
Authors: Gurvich Tatyana 
Published: November 2019

Abstract
We are in the midst of an opioid crisis, but have more patients in pain than ever before. Seniors have painful conditions such as chronic back pain, arthritis, neuropathy and fibromyalgia. As many as 50% of older Americans have pain daily from more advanced disease. CDC guidelines mandate that we use opioids less and adjuvant medications more. But using adjuvants in this patient population adds an extra layer of complexity. Some are not well tolerated contributing to cognitive decline, some have to be dose adjusted for declining kidney or liver function. Some medications are safe but underutilized by this patient population. Strategies for safe opioid use will be discussed from both provider and patient perspectives. A review of adjuvant medication will be provided focusing on safe medication use in seniors. Prescription and over-the-counter and alternative medications will be reviewed.
ANALYSIS OF REST-ACTIVITY RHYTHMS AND RISK OF INCIDENT MILD COGNITIVE IMPAIRMENT AND DEMENTIA IN OLDER WOMEN
Authors: Stone Katie L , Stone Katie L , Blackwell Terri , Zeitzer Jamie , Yaffe Kristine , Ancoli-Israel Sonia , Redline Susan , Tranah Gregory J 
Published: November 2019

Abstract
In older adults, desynchronized circadian rhythms have been associated with medical illness, including Alzheimer Disease. Activity, which can be easily measured using actigraphy over consecutive 24-hour periods, is a valid marker of entrained sleep phase and correlates with entrained endogenous circadian phase. We compare results of both parametric and non-parametric analyses to test the association of rest-activity patterns with incident MCI and dementia in 2132 older women who had 2 or more 24-hrs periods of actigraphy data collected at baseline. Follow-up neuropsychological testing approximately 5 years later is used to classify women as normal, MCI, or dementia. Logistic regression models are adjusted for age, clinic site, race, education, body mass index, functional status, comorbidities, medication use, and health habits. Results suggest the importance of overall amplitude and rhythmicity, as well as timing of activity patterns over the 24-hour day as risk factors for incident MCI/dementia.
INTEREST GROUP SESSION—PATIENT/PERSON ENGAGEMENT IN RESEARCH INTEREST GROUP (PPER-IG): STRENGTH IN AGE: ENGAGING OLDER ADULTS AS HEALTH RESEARCHERS THROUGH COMMUNITY-BASED PARTNERSHIPS
Authors: Sörensen Silvia , Allen Rebecca S , Nooraie Reza Yousefi 
Published: November 2019

Abstract
The lack of clear translation of health research to improving older under-served patients’ lives presents a serious problem. Studies of aging rarely include the older adults themselves in the process of conceptualizing questions, implementing the research, and applying and evaluating the results. Lack of input particularly from marginalized and minority older adults may compromise the relevance and accuracy of health research findings. In this symposium, we present the design and evaluation of two projects funded by the Patient-Centered Outcomes Research Institute (PCORI), in which older adults are trained to understand research language, culture, and methods, and are subsequently incorporated into research projects in a variety of roles. Silvia Sörensen will describe the “Engaging Older Adult Learners as Health Researchers” (ENGOAL) in Rochester, NY. This program provides six months of weekly classes and 4-6 months of research apprenticeships for older adults. Dorine Otieno and Kate Kondolf will describe evaluation results from both quantitative and qualitative analyses. Rebecca Allen will describe the design and implementation of “Sharing Opinions and Advice about Research (SOAR) in the Deep South,” a partnership of The University of Alabama with community stakeholders from Sumter and Holt County to recruit and train community members to assist in the formulation of research questions based on the needs of their communities. Allen and Dragan will present the evaluation results from this project with regard to implementation and graduate education. Reza Yousefi-Nooraie will synthesize the insights from these projects and add the perspective of a social network analyst.
PROJECT SOAR PARTNERSHIPS: EXPLORING ADVANCE CARE PLANNING AMONG RURAL AFRICAN AMERICANS
Authors: Allen Rebecca S , Payne-Foster Pamela , Oliver JoAnn S , Spencer Christopher H , Dragan Deanne M 
Published: November 2019

Abstract
Sharing Opinions and Advice about Research (Project SOAR), funded by PCORI, trained individuals living in under-resourced and underserved communities how to evaluate and provide advice to scientists about recruitment procedures, survey items, and intervention components for implementation in their communities. In partnership with the HELLO Project (Van Scoy, Green, & Volpe, 2019), Project SOAR community partners recruited 50 rural African American adults to consider their values, plans, and treatment preferences near the end of life while playing the HELLO game. Community and research partners along with a HELLO Project representative facilitated questionnaire completion and the process of the HELLO game to promote advance care planning. Tables of 10 participants held facilitated discussions for each HELLO game item and recorded their individual wishes and plans in HELLO booklets. Community participants had difficulty completing questionnaires without assistance; however, all were engaged and accepting of game-like discussions regarding advance care planning.