bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Potential of Compounds from the Brazilian Blue Amazon
Authors: Wilke Diego V. , Jimenez Paula C. , Branco Paola C. , Rezende-Teixeira Paula , Trindade-Silva Amaro E. , Bauermeister Anelize , Lopes Norberto Peporine , Costa-Lotufo Leticia V. 
Published: November 2020

Abstract“Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of their genes meet some of these other layers. These metabolites produced by terrestrial creatures traditionally and lately added to by those from marine organisms are recognized for their pharmaceutical value, since over 50% of small molecule-based medicines are related to natural products. Nonetheless, Brazil gives a modest contribution to the field of pharmacology and even less when considering marine pharmacology, which still lacks comprehensive in-depth assessments toward the bioactivity of marine compounds so far. Therefore, this review examined the last 40 years of Brazilian natural products research, focusing on molecules that evidenced anticancer potential–which represents ~ 15% of marine natural products isolated from Brazilian species. This review discusses the most promising compounds isolated from sponges, cnidarians, ascidians, and microbes in terms of their molecular targets and mechanisms of action. Wrapping up, the review delivers an outlook on the challenges that stand against developing groundbreaking natural products research in Brazil and on a means of surpassing these matters.
Update Breast Cancer 2020 Part 4 – Advanced Breast Cancer
Authors: Tesch Hans , Müller Volkmar , Wöckel Achim , Ettl Johannes , Belleville Erik , Schütz Florian , Hartkopf Andreas , Thill Marc , Huober Jens , Fasching Peter A. , Kolberg Hans-Christian , Schulmeyer Carla E. , Welslau Manfred , Overkamp Friedrich , Fehm Tanja N. , Lux Michael P. , Schneeweiss Andreas , Lüftner Diana , Janni Wolfgang 
Published: November 2020

AbstractSubstances with good effectiveness that intervene in specific signalling pathways have been used increasingly in recent years in the treatment of patients with advanced breast cancer, and new therapies and approaches have now been added, which actually relate to quite specific changes, such as the treatment of patients with HR+/HER2 tumours with a PIK3CA mutation. The treatment of patients with a BRCA1 or BRCA2 mutation has also been improved by the introduction of PARP inhibitors. Attempts are now being made increasingly to extend treatment indications based on molecular patterns, to identify other patients who could benefit from a treatment and to integrate the newly established treatment methods in existing therapy sequences. This review articles summarises the latest information in this connection.
Differentiating Enteroviral Meningitis from Bacterial Meningitis in Neonates
Authors: Luherne Vincent , Gromand Marie , Traversier Nicolas , Harrikaran-Biland Shelley , Alessandri Jean-Luc , Robin Stephanie , Ramful Duksha 
Published: November 2020

Abstract
Objective To compare the demographical, clinical and laboratory features, and outcomes of neonates with enteroviral meningitis (EVM) with those with bacterial meningitis (BM).
Methods A retrospective two-center study was performed in La Réunion Island between January 2008 and December 2018 in hospitalized neonates aged less than 29 days. Patients positive for enterovirus real-time polymerase chain reaction from the cerebrospinal fluid (CSF) were diagnosed with EVM. Neonates with positive CSF culture results for a potentially pathogenic bacterium were diagnosed with BM.
Results Compared with their EVM peers (n = 20), BM-infected neonates (n = 14) had lower birth weight, and were more likely to present hypotension and neurological symptoms on admission. Thrombocytopenia, elevated serum procalcitonin, hyperproteinorachia, hypoglycorrhachia, CSF pleocytosis, a bacterial meningitis score >0 were more frequent in the BM-infected group. All BM-infected neonates had at least one abnormal cutoff value in the CSF, while nine neonates (45%) in the EVM group had no CSF abnormality (p = 0.004). BM-infected neonates also had a longer length of hospital stay, needed more supportive care, received more prolonged antimicrobial courses, and developed respiratory and neurological complications.
Conclusion Recognition of some clinical and laboratory features can help clinicians in differentiating BM from EVM when managing this high-risk patient group.
Origin of Catheter-Related Bloodstream Infections Caused by Staphylococcus epidermidis in Critical Neonates
Authors: Resende Daiane Silva , Queiroz Lícia Ludendorff , de Campos Paola Amaral , Gontijo-Filho Paulo Pinto , Araújo Bruna Fuga , de Brito Cristiane Silveira , Urzedo Jane Eire , Ribas Rosineide Marques 
Published: November 2020

AbstractBloodstream infection (BSI) remains the most frequent adverse event among premature infants worldwide, associated with increased hospital stay length and costs, poor outcomes, and even death. The aim of this study was to investigate the origin of catheter-related bloodstream infections (CR-BSIs) by Staphylococcus epidermidis in critical neonates, using molecular biology techniques. This was an observational study comprising neonates presenting BSI using central venous catheters (CVCs) for over 24 hours. Skin cultures obtained from the catheter insertion site, CVC hub, and neonate nasal and intestinal mucosa, were performed weekly from 48 hours from the beginning of the invasive procedure, as well as from the tip of the CVC after its withdrawal. Quantitative cultures were also performed of the tip with modifications and the “roll-plate” technique. Isolates identification were obtained using a VITEK II automated system. Molecular subtyping by pulsed-field gel electrophoresis (PFGE) was used to determine the origin of all BSIs. Among 19 primary BSI caused by S. epidermidis, BSI origin was defined in only 21.1% of the cases, where one was characterized as definite intraluminal, two as definite extraluminal, and one as translocation. Origin was indeterminate in 78.9% of the cases analyzed by PFGE. A total of 27 different genotype profiles were obtained. The spread of a prevalent clone in the unit (clone A) was detected in 28.6% of the samples. Most BSIs related to catheter caused by S. epidermidis were not able to prove the origin of most microorganisms present in neonate blood, demonstrating the difficulty in determining it in this population of patients. The lack of a better explanation of the origin of CR-BSI in neonates limits the direction of specific intervention measures.
Representation of solutions of the Cauchy problem for a one-dimensional Schrödinger equation with a smooth bounded potential by quasi-Feynman formulae
Authors: Grishin D. V. , Pavlovskiy Ya. Yu. 
Published: November 2020

Abstract
We consider the Cauchy problem for a Schrödinger equation whose Hamiltonian is the difference of the operator of multiplication by the potential and the operator of taking the second derivative. Here the potential is a real differentiable function of a real variable such that this function and its derivative are bounded. This equation has been studied since the advent of quantum mechanics and is still a good model case for various methods of solving partial differential equations. We find solutions of the Cauchy problem in the form of quasi-Feynman formulae by using Remizov’s theorem. Quasi-Feynman formulae are relatives of Feynman formulae containing multiple integrals of infinite multiplicity. Their proof is easier than that of Feynman formulae but they give longer expressions for the solutions. We provide detailed proofs of all theorems and deliberately restrict the spectrum of our results to the domain of classical mathematical analysis and elements of real analysis trying to avoid general methods of functional analysis. As a result, the paper is long but accessible to readers who are not experts in the field of functional analysis.
Interior estimates for solutions of linear elliptic inequalities
Authors: Klimov V. S. 
Published: November 2020

Abstract
We study the wedge of solutions of the inequality

, where

is a linear elliptic operator of order

acting on functions of

variables. We establish interior estimates of the form

for the elements of this wedge, where

is a compact subdomain of

,

is the Sobolev space,

,

is the Lebesgue space of integrable functions, and the constant

is independent of

.
Positive solutions of superlinear elliptic problems with discontinuous non-linearities
Authors: Pavlenko V. N. , Potapov D. K. 
Published: November 2020

Abstract
We consider an elliptic boundary-value problem with a homogeneous Dirichlet boundary condition, a parameter and a discontinuous non-linearity. The positive parameter appears as a multiplicative term in the non-linearity, and the problem has a zero solution for any value of the parameter. The non-linearity has superlinear growth at infinity. We prove the existence of positive solutions by a topological method.
Uniform approximation of functions by solutions of second order homogeneous strongly elliptic equations on compact sets in
Authors: Mazalov M. Ya. 
Published: November 2020

Abstract
We obtain a criterion for the uniform approximability of functions by solutions of second-order homogeneous strongly elliptic equations with constant complex coefficients on compact sets in

(the particular case of harmonic approximations is not distinguished).
The criterion is stated in terms of the unique (scalar) Harvey–Polking capacity related to the leading coefficient of a Laurent-type expansion (this capacity is trivial in the well-studied case of non-strongly elliptic equations).
The proof uses an improvement of Vitushkin’s scheme, special geometric constructions, and methods of the theory of singular integrals. In view of the inhomogeneity of the fundamental solutions of strongly elliptic operators on

, the problem considered is technically more difficult than the analogous problem for

,

.
On the Newton polyhedron of a Jacobian pair
Authors: Makar-Limanov L. G. 
Published: November 2020

Abstract
We introduce and describe the Newton polyhedron related to a “minimal” counterexample to the Jacobian conjecture. This description allows us to obtain a sharper estimate for the geometric degree of the polynomial mapping given by a Jacobian pair and to give a new proof in the case of the Abhyankar’s two characteristic pairs.
Progress in the medicinal chemistry of organoboron compounds
Authors: Tevyashova Anna N. , Chudinov Mikhail V. 
Published: November 2020

The review aims to draw attention to the latest advances in the organoboron chemistry and therapeutic use of organoboron compounds. The synthetic strategies towards boron-containing compounds with proven in vitro and/or in vivo biological activities, including derivatives of boronic acids, benzoxaboroles, benzoxaborines and benzodiazaborines, are summarized. Approaches to the synthesis of hybrid structures containing an organoboron moiety as one of the pharmacophores are considered, and the effect of this modification on the pharmacological activity of the initial molecules is analyzed. On the basis of analysis of the published data, the most promising areas of research in the field of organoboron compounds are identified, including the latest methods of synthesis, modification and design of effective therapeutic agents.
The bibliography includes 246 references.
Cyclic oxonium derivatives of cobalt and iron bis(dicarbollides) and their use in organic synthesis
Authors: Druzina Anna A. , Shmalko Akim V. , Sivaev Igor B. , Bregadze Vladimir I. 
Published: November 2020

The rapid progress in the chemistry of carboranes and other polyhedral boron compounds makes the development of methods for the synthesis of their various functional derivatives a high priority. The formation of cyclic oxonium derivatives followed by the ring opening is one of the most efficient methods for the preparation of these compounds. This review addresses the data on the use of the nucleophilic ring opening of cyclic oxonium derivatives based on cobalt and iron bis(dicarbollides), which have been extensively studied in recent years. Reactions involving O-, N-, S-, P- and C-nucleophiles are considered as a route to the targeted synthesis of a wide range of organic boron derivatives, in particular various boron-containing biologically active compounds. Possible applications of the reaction products are discussed.The bibliography includes 197 references.
Proof of a conjecture of Wiegold for nilpotent Lie algebras
Authors: Skutin A. A. 
Published: November 2020

Abstract
Let

be a nilpotent Lie algebra. By the breadth

of an element

of

we mean the number

. Vaughan-Lee showed that if the breadth of all elements of the Lie algebra

is bounded by a number

, then the dimension of the commutator subalgebra of the Lie algebra does not exceed

. We show that if

for some nonnegative

, then the Lie algebra

is generated by the elements of breadth

, and thus we prove a conjecture due to Wiegold (Question 4.69 in the Kourovka Notebook) in the case of nilpotent Lie algebras.
Bibliography: 4 titles.
Quantum spin-liquid states in an organic magnetic layer and molecular rotor hybrid
Authors: Szirmai Péter , Mézière Cécile , Bastien Guillaume , Wzietek Pawel , Batail Patrick , Martino Edoardo , Mantulnikovs Konstantins , Pisoni Andrea , Riedl Kira , Cottrell Stephen , Baines Christopher , Forró László , Náfrádi Bálint 
Published: November 2020

Significance
A better understanding of quantum spin liquids (QSLs), where spin dimer configurations are fluctuating even at the lowest temperatures, could be of use in quantum information, in superconducting or other technologies. This macroscopic collective state typically arises from geometrical frustration or low dimensionality. In the layered EDT-BCO, we report a QSL state, which is generated, on different bases, with the intrinsic disorder. The spins in the EDT plane despite a weak frustration would magnetically order but the disorder potential coming from the molecular rotors in the BCO plane prevents it. With multiple experimental probes, the stabilization of a QSL state is demonstrated with signatures of orphan spins, as defects between the QSL domains.
Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi
Authors: Kalogriopoulos Nicholas A. , Lopez-Sanchez Inmaculada , Lin Changsheng , Ngo Tony , Midde Krishna K. , Roy Suchismita , Aznar Nicolas , Murray Fiona , Garcia-Marcos Mikel , Kufareva Irina , Ghassemian Majid , Ghosh Pradipta 
Published: November 2020

Significance
Growth factors and heterotrimeric G proteins are two of the most widely studied signaling pathways in eukaryotes; their cross-talk shapes some of the most fundamental cellular responses in both health and disease. Although mechanisms by which G protein pathways transactivate growth factor receptor tyrosine kinases (RTKs) have been well-defined, how the reverse may happen is less understood. This study defines the key steps and cellular consequences of a fundamental mechanism of signal cross-talk that enables RTKs to transactivate heterotrimeric G protein, Gαi. Mutations found in tumors shed light on how derailing this mechanism impacts tumor cell behavior. Thus, findings not only show how cells integrate extracellular signals via pathway cross-talk, but also demonstrate the relevance of this pathway in cancers.
An evolutionarily acquired microRNA shapes development of mammalian cortical projections
Authors: Diaz Jessica L. , Siththanandan Verl B. , Lu Victoria , Gonzalez-Nava Nicole , Pasquina Lincoln , MacDonald Jessica L. , Woodworth Mollie B. , Ozkan Abdulkadir , Nair Ramesh , He Zihuai , Sahni Vibhu , Sarnow Peter , Palmer Theo D. , Macklis Jeffrey D. , Tharin Suzanne 
Published: November 2020

SignificanceThe mammalian central nervous system contains unique projections from the cerebral cortex thought to underpin complex motor and cognitive skills, including the corticospinal tract and corpus callosum. The neurons giving rise to these projections—corticospinal and callosal projection neurons—develop from the same progenitors, but acquire strikingly different fates. The broad evolutionary conservation of known genes controlling cortical projection neuron fates raises the question of how the more narrowly conserved corticospinal and callosal projections evolved. We identify a microRNA cluster selectively expressed by corticospinal projection neurons and exclusive to placental mammals. One of these microRNAs promotes corticospinal fate via regulation of the callosal gene LMO4, suggesting a mechanism whereby microRNA regulation during development promotes evolution of neuronal diversity.
Spatial and temporal diversity of glycome expression in mammalian brain
Authors: Lee Jua , Ha Seungshin , Kim Minsoo , Kim Seong-Wook , Yun Jaekyung , Ozcan Sureyya , Hwang Heeyoun , Ji In Jung , Yin Dongtan , Webster Maree J. , Shannon Weickert Cynthia , Kim Jae-Han , Yoo Jong Shin , Grimm Rudolf , Bahn Sabine , Shin Hee-Sup , An Hyun Joo 
Published: November 2020

Significance
Deciphering molecular mechanisms at the glycome level in mammalian brain remains a missing piece of the puzzle in molecular neuroscience due to the intrinsic complexity of glycosylation and the lack of analytical tools. Here, we uncovered the variation and diversity of glycome expression in human and mouse brain samples according to spatial and temporal differences. We further constructed a comprehensive synthesis map using glycans structurally elucidated by LC-MS/MS and found strong evidence on the conservation and developmental divergence of human and mouse prefrontal cortex N-glycome. Our data could be the reference for future mammalian brain glycome study. Furthermore, it provides valuable information on human brain glycome, which has languished in relative obscurity.
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
Authors: Liese Susanne , Wenzel Eva Maria , Kjos Ingrid , Rojas Molina Rossana , Schultz Sebastian W. , Brech Andreas , Stenmark Harald , Raiborg Camilla , Carlson Andreas 
Published: November 2020

SignificanceIntraluminal vesicle (ILV) formation plays a crucial role in the attenuation of growth factor receptor signaling. The endosomal sorting complex required for transport (ESCRT-0 to -III/VPS4) mediates this process. The general dogma has been that upstream ESCRTs (0 to II) sequester receptors at the surface of endosomes and the downstream ESCRTs (III/VPS4) remodel the endosome membrane leading to the abscission and formation of receptor-containing ILVs. We now show that upstream ESCRTs not only sequester cargo, but in addition play a crucial role for the initiation of membrane shape remodeling in ILV budding. Through a combination of mathematical modeling and experimental measurements we show that upstream ESCRTs facilitate ILV budding by crowding with a high density in the membrane neck region.
Neural control of rapid binocular eye movements: Saccade-vergence burst neurons
Authors: Quinet Julie , Schultz Kevin , May Paul J. , Gamlin Paul D. 
Published: November 2020

Significance
Currently, it is not known whether disjunctive saccades, the eye movements generated when viewing objects in three-dimensional space, are produced solely by the vergence system, the saccadic system, or through some as-yet-undescribed neural circuitry. Here, we report the existence of a population of saccade-vergence burst neurons (SVBNs) in the central mesencephalic reticular formation that encode vergence velocity. They respond only during disjunctive saccades, and not during conjugate saccades or pure vergence movements, and their existence had been predicted by modeling studies. Our findings indicate that SVBNs are not only involved in the generation of disjunctive saccades, but they are the critical element for producing vergence changes at the speeds observed during disjunctive saccades.
Automatic speech recognition in the booth
Authors: Defrancq Bart , Fantinuoli Claudio 
Published: November 2020

Abstract
Automatic Speech Recognition (ASR) has been proposed as a means to enhance state-of-the-art computer-assisted interpreting
(CAI) tools and to allow machine-learning techniques to enter the workflow of professional interpreters. In this article, we test the
usefulness of real-time transcription with number highlighting of a source speech for simultaneous interpreting using InterpretBank ASR. The
system’s precision is high (96%) and its latency low enough to fit interpreters’ ear–voice span (EVS). We evaluate the potential benefits
among first-time users of this technology by applying an error matrix and by investigating the users’ subjective perceptions through a
questionnaire. The results show that the ASR provision improves overall performance for almost all number types. Interaction with the ASR
support is varied and participants consult it for just over half of the stimuli. The study also provides some evidence of the psychological
benefits of ASR availability and of overreliance on ASR support.
A projected gradient method for αℓ
1
−
βℓ
2 sparsity regularization
**
Authors: Ding Liang , Han Weimin 
Published: November 2020

Abstract
The non-convex

α
‖
⋅

‖

ℓ

1

−
β
‖
⋅

‖

ℓ

2

(

α
⩾
β
⩾
0

)

regularization is a new approach for sparse recovery. A minimizer of the

α
‖
⋅

‖

ℓ

1

−
β
‖
⋅

‖

ℓ

2

regularized function can be computed by applying the ST-(αℓ
1 − βℓ
2) algorithm which is similar to the classical iterative soft thresholding algorithm (ISTA). It is known that ISTA converges quite slowly, and a faster alternative to ISTA is the projected gradient (PG) method. However, the conventional PG method is limited to solve problems with the classical ℓ
1 sparsity regularization. In this paper, we present two accelerated alternatives to the ST-(αℓ
1 − βℓ
2) algorithm by extending the PG method to the non-convex

α
‖
⋅

‖

ℓ

1

−
β
‖
⋅

‖

ℓ

2

sparsity regularization. Moreover, we discuss a strategy to determine the radius R of the ℓ
1-ball constraint by Morozov’s discrepancy principle. Numerical results are reported to illustrate the efficiency of the proposed approach.
Theoretical study of electron impact single ionization of neon by multicenter three distorted-wave method at low projectile energy: an overall agreement with experiment
Authors: Gong Maomao , Wang Zhenpeng , Li Xingyu , Zhang Song Bin , Chen Xiangjun 
Published: November 2020

Abstract
Universal theoretical description of electron impact single ionization process for complex atoms and molecules is a long-standing challenge. A perturbative approach named multicenter three distorted wave method (MCTDW) has recently been developed by our group, aiming at calculating (e, 2e) fully differential cross sections for molecular target. In MCTDW method, the incident, scattered and ejected electrons are described by distorted waves using single center expansion technique. The continuum wave functions of the incident and two outgoing electrons are solved in the potential of neutral molecule and ion, respectively. The accuracy and generality of this method has been demonstrated for water molecule as well as simple two-electron atom helium (2018 Phys. Rev. A
98 042710) . Here MCTDW is extended to investigate more complex multi-electron atom neon of electron impact ionization from its 2p orbital at projectile energy of 100 eV and 65 eV. The results are compared with the internormalized experiments reported in the literatures (2013 Phys. Rev. Lett.
110 153202; 2015 Phys. Rev. A.
91 032707). An overall agreement has been achieved with experimental data for different scattering angles and energies, as well as theoretical calculations employing nonperturbative B-spline R-matrix with pseudostates approach.