bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consolidation with 90Yttrium‐ibritumomab tiuxetan after bendamustine and rituximab for relapsed follicular lymphoma
Authors: Miura Katsuhiro , Tsujimura Hideki , Masaki Yasufumi , Iino Masaki , Takizawa Jun , Maeda Yoshinobu , Yamamoto Kazuhiko , Tamura Shinobu , Yoshida Akiyo , Yagi Hideo , Yoshida Isao , Kitazume Koichi , Masunari Taro , Choi Ilseung , Kakinoki Yasutaka , Suzuki Ritsuro , Yoshino Tadashi , Nakamura Shigeo , Hatta Yoshihiro , Yoshida Takashi , Kanno Masatoshi 
Published: September 2020

AbstractBendamustine and rituximab (BR) are widely used in patients with follicular lymphoma (FL) previously treated with conventional immunochemotherapy, but the role of consolidation radioimmunotherapy in these patients is unknown. This study evaluated the efficacy and safety of consolidation with 90Yttrium‐ibritumomab tiuxetan (90Y‐IT) after re‐induction therapy with BR in patients with previously treated FL. This study included adult patients with relapsed FL who had undergone one or two prior therapies. Re‐induction therapy with BR was administered every 4 weeks up to 4–6 cycles. If patients achieved at least partial response, 90Y‐IT was administered as consolidation therapy. The primary endpoint was 2‐year progression‐free survival (PFS) after consolidation. A total of 24 FL patients (median age 60 years) who had undergone one (n = 17) or two (n = 7) prior treatments received BR. After BR therapy, 22 patients proceeded to consolidation with 90Y‐IT, resulting in an overall 88% response rate to the protocol treatment. Within a median observation period of 46.8 months, the estimated 2‐year PFS rate after the consolidation among the 22 patients receiving 90Y‐IT was 59% (95% confidence interval [CI], 38%–77%). Patients whose remission after previous treatment had lasted ≥2 years had a significantly higher 2‐year PFS rate than patients whose remission after previous treatment had been <2 years (68% vs. 33%, Wilcoxon p = 0.0211). Major adverse events during the protocol treatment and within 2 years after the consolidation were hematological toxicities, but they were generally acceptable. Consequently, the estimated 2‐year overall survival after the consolidation was 95% (95% CI, 74%–99%). In conclusion, in a subset of patients with previously treated FL, 90Y‐IT consolidation after BR re‐induction conferred a durable remission, indicating that consolidation therapy using 90Y‐IT may be a novel therapeutic option for patients with relapsed FL (UMIN000008793).
Hematopoietic stem cell transplantation for diffuse large B‐cell lymphoma having 8q24/MYC rearrangement in Japan
Authors: Takahashi Tsutomu , Suzuki Ritsuro , Yamamoto Go , Nakazawa Hideyuki , Kurosawa Mitsutoshi , Kobayashi Tsutomu , Okada Masaya , Akasaka Takashi , Kim Sung‐Won , Fukuda Takahiro , Ichinohe Tatsuo , Atsuta Yoshiko , Suzumiya Junji 
Published: September 2020

AbstractThe prognosis of diffuse large B‐cell lymphoma (DLBCL) having MYC rearrangement (MYC‐R), including double hit lymphoma (DHL), is poor by standard immunochemotherapy. To evaluate the significance of hematopoietic stem cell transplantation (SCT) for DLBCL with MYC‐R, we retrospectively analyzed Japanese SCT registry data. In total, 54 patients with DLBCL with MYC‐R were identified from 4336 registered adult DLBCL patients. Detailed clinical and cytogenetic information was obtained for 48 patients. The median age at diagnosis of the 48 patients was 54.5 (range 21–67) years. Twenty‐six (54%) patients had MYC‐R only (single hit), and 22 (46%) had MYC‐R and BCL2, and/or BCL6 rearrangement (double/triple hit). In 12 patients who received auto‐SCT during the first complete response (CR), both the 2‐year overall survival (OS) and progression‐free survival (PFS) rates were 75.0% (95% confidence interval [CI], 40.8%–91.2%). In 20 patients who received auto‐SCT after relapsed or refractory state, the 2‐year OS and PFS rates were 68.2% (95% CI, 41.9%–84.5%) and 59.6% (95% CI, 35.1%–77.4%), respectively. In 17 patients who received allo‐SCT, only 4 patients underwent SCT in CR. The 2‐year OS and PFS rates were 29.4% (95% CI, 10.7%–51.1%) and 17.6% (95% CI, 4.3%–38.3%), respectively. The rate of non‐relapse mortality at 1 year was 41.2% (95% CI, 17.1%–64.0%) in this group. The outcomes of single hit and double or triple hit were not different. These findings suggest that auto‐SCT may be effective for MYC‐R DLBCL, including DHL patients of chemosensitive relapsed or refractory state. Since most patients received allo‐SCT not in CR, the outcome of allo‐SCT was unsatisfactory due to high non‐relapse mortality and early relapse. To clarify the role of allo‐SCT for MYC‐R DLBCL, further accumulation of patients is necessary.
Dissolved organic carbon transport in the Qilian mountainous areas of China
Authors: Zhu Guofeng , Wan Qiaozhuo , Yong Leilei , Li Qiaoqiao , Zhang Zhiyuan , Guo Huiwen , Zhang Yu , Sun Zhigang , Zhang Zhuanxia , Ma Huiying 
Published: September 2020

AbstractThe Dissolved Organic Carbon (DOC) content of rivers is the most significant part of the carbon cycle migration in the basin under consideration, and it is the basis for a comprehensive understanding of the regional carbon cycle. In this study, we periodically collected samples from four monitoring stations in the Xiying River Basin of the Qilian Mountains in the northern Qinghai‐Tibet Plateau. We calculated the fluxes of organic carbon in the rivers within the study area and have discussed the influencing factors of DOC concentration in these rivers. The results showed that: (a) The DOC concentration and transport flux of the Xiying river showed significant seasonal changes. The DOC concentration during summer and autumn was higher than that in winter and spring, and the output flux in summer and autumn accounted for approximately 88.3% of the total annual output. (b) Precipitation runoff has a higher DOC concentration than meltwater runoff. Climate factors, river‐water chemical characteristics, and seasonal frozen‐soil changes in the river basin have significant effects on the river DOC concentration and transport flux. (c) Larger runoff causes higher DOC concentrations in rivers. Runoff is the primary means of carbon migration in the inland river basin. Carbon migration is significant from the upstream to the middle and downstream sections of the inland river basin.
Adverse caregiving in early life: The trauma and deprivation distinction in young children
Authors: Guyon‐Harris Katherine L. , Humphreys Kathryn L. , Zeanah Charles H. 
Published: September 2020

ABSTRACTKnowledge and understanding about the impact of cumulative adverse experiences on the health and wellbeing of children, adolescents, and adults has rapidly expanded over the past 30 years. Despite the invaluable attention and support this proliferation has drawn to the importance of early childhood experiences, we believe that it is time to move beyond broad indices of risk and toward more specific and individualized understanding of how risk exposures are linked to clinical outcomes in young children. Within infant and early childhood mental health, there is a need for greater specificity in linking adverse caregiving experiences in early life to psychopathology in children. We highlight a framework distinguishing experiences of trauma from experiences of deprivation and use the examples of posttraumatic stress disorder and reactive attachment disorder to demonstrate how greater specificity in our understanding of early adverse caregiving can lead to more accurate and targeted diagnosis and treatment for young children. Both researchers and clinicians benefit from an approach to gain a greater appreciation of the links between specific types of experiences and outcomes in the children that we serve.
Therapeutic prognosis of prostate cancer using surface‐enhanced Raman scattering of patient urine and multivariate statistical analysis
Authors: Ma Yiwei , Chi Jingmao , Zheng Zhaoyu , Attygalle Athula , Kim Isaac Yi , Du Henry 
Published: September 2020

AbstractSurface‐enhanced Raman scattering (SERS) is highly sensitive and label‐free analytical technique based on Raman spectroscopy aided by field‐multiplying plasmonic nanostructures. We report the use of SERS measurements of patient urine in conjunction with biostatistical algorithms to assess the treatment response of prostate cancer (PCa) in 12 recurrent (Re) and 63 nonrecurrent (NRe) patient cohorts. Multiple Raman spectra are collected from each urine sample using monodisperse silver nanoparticles (AgNPs) for Raman signal enhancement. Genetic algorithms‐partial least squares‐linear discriminant analysis (GA‐PLS‐LDA) was employed to analyze the Raman spectra. Comprehensive GA‐PLS‐LDA analyses of these Raman spectral features (p = 3.50 × 10−16) yield an accuracy of 86.6%, sensitivity of 86.0%, and specificity 87.1% in differentiating the Re and NRe cohorts. Our study suggests that SERS combined with multivariate GA‐PLS‐LDA algorithm can potentially be used to detect and monitor the risk of PCa relapse and to aid with decision‐making for optimal intermediate secondary therapy to recurred patients.
Structural basis of BMP‐2 and BMP‐7 interactions with antagonists Gremlin‐1 and Noggin in Glioblastoma tumors
Authors: Choudhuri Kesaban Sankar Roy , Mishra Seema 
Published: September 2020

AbstractIn Glioblastoma (GBM) brain tumors, both Gremlin‐1 and Noggin are reported to bind to BMP and inhibit BMP‐signaling, thereby allowing the cell to maintain tumorous morphology. Enlisting the interfacial residues important for protein–protein complex formation between BMPs (BMP‐2 and BMP‐7) and antagonists (Gremlin‐1 and Noggin), we analyzed the structural basis of their interactions. We found possible key mutations that destabilize these complexes, which may prevent GBM development. It was also observed that when the interfacial residues were either mutated to histidine or tryptophan, it led to higher destabilization energy values. Besides, our study of the Noggin interactive model of BMP‐2 suggested preferential binding at binding site II over binding site I. In the case of Gremlin‐1 and BMPs, our research, along with few previous studies, indicates a close‐ended cis‐trans interactive model.
Correlation between single nucleotide polymorphisms in CXCR4 microRNA binding site and the susceptibility to knee osteoarthritis in Han Chinese population
Authors: Wang Yang , Li Yanlin , Jia Di , Zheng Jiali , Wang Guoliang 
Published: September 2020

AbstractBackgroundThis study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) at the microRNA target sequence in CXCR4 and the susceptibility to knee osteoarthritis (KOA).MethodsA total of 305 patients with KOA and 305 healthy controls were recruited into this study. The genotypes of CXCR4 rs1804029 and rs17848060 loci were analyzed.ResultsThe susceptibility to KOA of CXCR4 rs1804029 G allele carriers was 1.33 times (95% CI: 1.09‐1.54, P = .006) that of T allele carriers. The KOA susceptibility in individuals carrying T allele at CXCR4 rs17848060 locus was 1.38 times that of individuals carrying A allele (95% CI: 1.17‐1.57, P < .001). The G allele at CXCR4 rs1804029 locus was the target of hsa‐miR‐146a‐3p, while the A allele at CXCR4 rs17848060 locus could be targeted by hsa‐miR‐20a‐3p. The plasma level of hsa‐miR‐146a‐3p was lower in rs1804029 G allele carriers than T allele carriers (P < .001), whereas plasma level of hsa‐miR‐20a‐3p was higher in rs17848060 T allele carriers than A allele carriers (P < .001).ConclusionThe SNPs at rs1804029 and rs17848060 loci in CXCR4 were significantly associated with the susceptibility to KOA in Han Chinese population.
A rod‐like mesoporous carbon derived from agro‐industrial cassava petiole waste for supercapacitor application
Authors: Taer Erman , Apriwandi Apriwandi , Dalimunthe Bima Kumala Levanadea , Taslim Rika 
Published: September 2020

AbstractBACKGROUNDAgro‐industrial co‐products rich in lignocellulose, for example cassava petiole (CP) waste, have high potential as sources of porous carbon materials, alongside other impressive advantages, including ease of acquisition, abundance and availability, renewability and low cost. This work shows the successful treatment of mesoporous carbon with rod‐like structure derived from agro‐industrial CP waste carbonized and physically activated by direct one‐stage integrated pyrolysis using a zinc chloride (ZnCl2) activator agent, in the production of a supercapacitor electrode for energy storage. The ZnCl2 was tested at varying concentrations, including 0.5, 0.7 and 0.9 mol L–1. The surface morphology, chemical content, surface area and porous size distribution were evaluated to determine the physical properties of activated carbon, and a cyclic voltammetry method was used to assess the electrochemical characteristics using a two‐electrode system in 1 mol L–1 H2SO4 as an electrolyte.RESULTSThe porous carbon obtained displayed a rod‐like morphology structure, featuring numerous hierarchical tuneable and well‐confirmed micropores and mesopores. This monolithic material contained predominantly C (87.85%), demonstrating a maximum surface area of 759.816 m2 g−1 at 0.9 mol L–1 concentration. Furthermore, the highest specific capacitance reached was 193 F g−1 at 0.7 mol L–1, with maximum energy and power densities of 26.90 Wh kg−1 and 96.94 W kg−1, respectively.CONCLUSIONThe novel rod‐like mesoporous carbon derived from CP waste produced using a facile, cost‐effective and sustainable method, without metal–organic framework or templates, shows great potential as an electrode material for enhanced supercapacitor performance. © 2020 Society of Chemical Industry (SCI)
Development of a novel integrated educational relative‐unit value system to assess dental students' clinical performance
Authors: Agou Shoroog Hassan , Imam Ahmad Yahya 
Published: September 2020

AbstractPurposeThe use of relative unit values (RUVs) to assess students’ clinical productivity is common in dental education. However, there are large variations on how RUVs are defined, developed, validated, and reported across institutions. This study described the development of a novel educational RUV system.MethodsA preparatory phase of literature review and methodological gap analysis, followed by initial conception, pilot testing, and a 2‐round modified Delphi process were conducted. Panelists reviewed the procedure list, nomenclature, purpose of development, basis of calculation of RUVs, and the relative weights of different dental procedures. Also, their perception of the usefulness, fairness, and practicality of the system was assessed. Agreement was set at 80%.ResultsEight published educational RUV systems were identified. These data guided the initial conception of the novel Integrated Educational RUVs (IERUVs). Five experts reviewed the system and it was piloted for a full educational cycle. Feedback from faculty and students was used to adjust over‐ or under‐estimated RUVs, with deconstruction of multi‐step procedures. Fifteen experts participated in the second Delphi round (71% response rate). Consensus was reached for 105 procedural RUVs. A total of 93% of the panelists agreed the system was useful, while 71% perceived it as fair and practical.Conclusion(s)Content validity of the new educational RUV was established. The system provides a promising tool for assessing dental students’ clinical performance, as it provides a unified base unit to assess clinical productivity, clinical competence, and comprehensive care cases. Longitudinal evaluations in different contexts are needed to confirm IERUVs validity.
Initial symptoms of patients with coronavirus disease 2019 in Japan: A descriptive study
Authors: Komagamine Junpei , Yabuki Taku 
Published: September 2020

AbstractFever, cough, malaise, and sore throat are the most common initial symptoms of coronavirus disease 2019 (COVID‐19). However, no studies have ever been conducted to investigate the initial symptoms of COVID‐19 in Japan. By using publicly available data, we investigated 707 consecutive COVID‐19 patients who were diagnosed in 10 prefectures of Japan prior to May 16, 2020. The primary outcomes were the initial symptoms on the day of symptom onset. The proportions of patients with each symptom among the symptomatic patients were calculated. Of all the patients, 79 (11.2%) were asymptomatic. Among the 628 symptomatic patients, the most common initial symptom was fever (65.9%), followed by cough (23.5%), malaise (23.5%), and sore throat (12.9%). At least one of these four symptoms was reported in 88.2% of all symptomatic patients. Nineteen patients (3.0%) reported gastrointestinal symptoms without respiratory symptoms, while six patients (1.0%) reported only the loss of smell or taste as the initial symptom. As in other countries, the most common initial symptoms of COVID‐19 in Japan are fever, cough, malaise, and sore throat. Gastrointestinal symptoms without respiratory symptoms and the loss of smell and taste are uncommon initial symptoms in Japan.
Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4‐thiazolidinone and 1,2,4‐triazole‐3‐thione derivatives
Authors: Dincel Efe Doğukan , Ulusoy‐Güzeldemirci Nuray , Şatana Dilek , Küçükbasmacı Ömer 
Published: September 2020

AbstractA series of novel hydrazinecarbothioamide (5a,c,f), 4‐thiazolidinone (6a‐e), and 1,2,4‐triazole‐3‐thione (7a‐d) were designed and synthesized. The structural elucidations of the novel compounds were performed by IR, 1H‐NMR, 13C‐NMR, mass and elemental analysis. All novel derivatives were evaluated for their antibacterial and antifungal activities against nine diverse microorganisms. According to the biological activity studies of the compounds, 6d, 7c and 7d displayed hope promising antibacterial activity. Furthermore, 6d displayed potent antifungal activity. Consequently, the obtained results revealed that 6d, 7c and 7d present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.
Prediction Model Combining Clinical and MR Data for Diagnosis of Lymph Node Metastasis in Patients With Rectal Cancer
Authors: Xu Hanshan , Zhao Wenyuan , Guo Wenbing , Cao Shaodong , Gao Chao , Song Tiantian , Yang Liping , Liu Yanlong , Han Yu , Zhang Lingbo , Wang Kezheng 
Published: September 2020

BackgroundDetermining the status of lymph node (LN) metastasis in rectal cancer patients preoperatively is crucial for the treatment option. However, the diagnostic accuracy of current imaging methods is low.PurposeTo develop and test a model for predicting metastatic LNs of rectal cancer patients based on clinical data and MR images to improve the diagnosis of metastatic LNs.Study typeRetrospective.SubjectsIn all, 341 patients with histologically confirmed rectal cancer were divided into one training set (120 cases) and three validation sets (69, 103, 49 cases).Field strength/sequence3.0T, axial and sagittal T2‐weighted turbo spin echo and diffusion‐weighted imaging (b = 0 s/mm2, 800 s/mm2)AssessmentIn the training dataset, univariate logistic regression was used to identify the clinical factors (age, gender, and tumor markers) and MR data that correlated with LN metastasis. Then we developed a prediction model with these factors by multiple logistic regression analysis. The accuracy of the model was verified using three validation sets and compared with the traditional MRI method.Statistical testsUnivariate and multivariate logistic regression. The area under the curve (AUC) value was used to quantify the diagnostic accuracy of the model.ResultsEight factors (CEA, CA199, ADCmean, mriT stage, mriN stage, CRM, EMVI, and differentiation degree) were significantly associated with LN metastasis in rectal cancer patients (P<0.1). In the training set (120) and the three validation sets (69, 103, 49), the AUC values of the model were much higher than the diagnosis by MR alone (training set, 0.902 vs. 0.580; first validation set, 0.789 vs. 0.743; second validation set, 0.774 vs. 0.573; third validation set, 0.761 vs. 0.524).Data ConclusionFor the diagnosis of metastatic LNs in rectal cancer patients, our proposed logistic regression model, combining clinical and MR data, demonstrated higher diagnostic efficiency than MRI alone.Level of Evidence4Technical Efficacy Stage2
T1 Mapping on Gd‐EOB‐DTPA‐Enhanced MRI for the Prediction of Oxaliplatin‐Induced Liver Injury in a Mouse Model
Authors: Yang Li , Ding Ying , Rao Shengxiang , Chen Caizhong , Zeng Mengsu 
Published: September 2020

BackgroundOxaliplatin‐induced liver injury (OILI) not only impairs hepatic regeneration but also increases postoperative morbidity and mortality. Therefore, noninvasive, accurate, and early diagnosis of OILI is mandatory.PurposeTo evaluate the potential of T1 mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MRI for assessing OILI in a mouse model.Study TypeCase control, animal model.Animal ModelThirty oxaliplatin‐treated mice and 10 control mice were included.Field StrengthVolumetric interpolated breath‐hold examination sequence: 3T scanner with a phased‐array animal 8‐channel coil. T1 mapping before and at hepatobiliary phase (HBP) after injection of Gd‐EOB‐DTPA were undertaken.AssessmentT1 relaxation times of the liver parenchyma were measured and the reduction rate (ΔT1%) was calculated. Histological findings were used as a standard reference.Statistical TestsThe Kruskal–Wallis test with pairwise comparisons using the Mann–Whitney U‐test were applied to compare the parameters across groups. Spearman's rank correlation test and receiver operating characteristics (ROC) analyses were performed. Areas under the curves (AUCs) were compared using the DeLong method.ResultsHistologically, mice were classified as normal (n = 10), hepatocellular degeneration without fibrosis (n = 16), and hepatocellular degeneration with fibrosis (n = 14). HBP T1 relaxation time increased with the severity of OILI (rho = 0.60, P < 0.05), and ΔT1% decreased with the severity of OILI (rho = –0.78, P < 0.05). AUC was 0.92 for ΔT1% in differentiating hepatocellular degeneration without fibrosis from normal liver, but HBP T1 relaxation time could not distinguish them (P = 0.09). AUCs were 0.96 and 0.95 for HBP T1 relaxation time, and 0.90 and 0.84 for ΔT1% in discriminating OILI with fibrosis from normal liver and OILI without fibrosis.Data ConclusionHBP T1 relaxation time and ΔT1% of Gd‐EOB‐DTPA enhanced MRI was useful for assessing OILI. ΔT1% may be more sensitive than HBP T1 relaxation time in detecting early stage of liver injury.Level of Evidence2.Technical Efficacy Stage5.