bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transient left bundle branch block and poor atrioventricular conduction during ablation of accessory pathway at the left ventricle
Authors: Chiang Kuo‐Feng , Wang Chi‐Yen , Huang Jin‐Long , Hsieh Yu‐Cheng 
Published: October 2020

AbstractA 56‐year‐old female with manifest Wolff‐Parkinson‐White (WPW) syndrome was sent to emergency room because of preexcited atrial fibrillation (AF) and became sinus rhythm after cardioversion. Then, she received catheter ablation of a left‐sided lateral accessory pathway. The patient immediately developed Wenckebach atrioventricular (AV) block and left bundle branch block (LBBB) during the initial ablation. The ECG still showed LBBB 1 hour after ablation. The LBBB became narrow QRS (The QRS complex in the electrocardiogram. The QRS complex includes the Q wave, R wave, and S wave) 1 day later. Two weeks later, Holter's ECG showed normal sinus rhythm with 1:1 AV conduction even at the maximum heart rate of 125 beats/min. Transient LBBB and poor AV nodal conduction could occur during ablation by the trans‐aortic approach.
Increasing energy transfer over Eurasia and the North Atlantic enhancing the Eurasian low‐frequency wave and boreal summer droughts in China
Authors: Zhang Jie , Zhao Siwen , Chen Zhiheng 
Published: October 2020

AbstractThe prolonged droughts that frequently occur in northern China are related to persistent anomalies of circulation and the low‐frequency waves. To explore the formation of the low‐frequency waves and the related internal variability and external forcing, the intra‐seasonal kinetic energy (KE) and the corresponding energy transfer terms are investigated algorithmically with multiscale energy and vorticity analysis. The results show two major energy sources located over the central North Atlantic (NA) and Europe, with increasing baroclinicity and energy conversion. The major energy conversion is from basic flow to intra‐seasonal KE, which corresponds to a southeastern extension of NA jet stream (JS) exit and the northward shift in the entrance of Afro Asian JS. JS shifts are helpful to the conjunction of both JS, and thereby enhance JS waveguide and wave energy dispersion. In addition, with increasing surface temperature and diabatic heating over Europe and the Mediterranean Sea, there are increase baroclinicity that facilitates the buoyancy energy conversion, ascending KE flux and positive pressure flux in the lower troposphere, those result in higher mid‐upper‐troposphere KE. The divergent energy contributes to the development and enhancement of the low‐frequency waves, favouring the extratropical eddy, wave structure, and quasi‐stationary waves amplitude, which is thereby conducive to magnified wave amplitude and extreme droughts in northern China. The results emphasize the internal dynamics and local forcing and provide prediction reference for extratropical extremes.
Elevated plasma D‐dimer concentration has higher efficacy for the diagnosis of periprosthetic joint infection of the knee than of the hip—A single‐center, retrospective study
Authors: Grzelecki Dariusz , Walczak Piotr , Grajek Aleksandra , Szostek Marta , Dudek Piotr , Bartosz Paweł , Olewnik Łukasz , Czubak‐Wrzosek Maria , Marczak Dariusz , Tyrakowski Marcin 
Published: October 2020

AbstractThe aim of this study is to evaluate the value of D‐dimers in the diagnosis of periprosthetic joint infection (PJI). The analysis was performed for revision total hip (rTHA) and revision total knee arthroplasty (rTKA) together and separately with two thresholds, one calculated by statistical methods and the second adopted from the ICM 2018 definition. The study group comprised 133 patients who underwent rTHA or rTKA: 68 patients diagnosed according to the ICM 2018 definition (PJI group) and 65 with aseptic implant loosening, instability, malposition, or implant failure with the exclusion of infection (aseptic revision total joint arthroplasty or arTJA group). Mean D‐dimer concentrations were 0.36 ± 0.25 μg/ml in the arTJA group and 0.87 ± 0.78 μg/ml in the PJI group (p < .001). For rTHA and rTKA together, the sensitivity and specificity of the evaluation were 75% and 73.8% according to the calculated cut‐off value (0.45 μg/ml), and 33.8% and 95.4% based on the ICM 2018 threshold (0.85 μg/ml). Separately, for rTHA, sensitivity and specificity were 62.5% and 62.1% for the calculated value (0.43 μg/ml) and 6.3% and 96.6% for the ICM 2018 threshold; for rTKA, sensitivity was 86.1% and specificity was 88.9% for the calculated threshold (0.48 μg/ml) and 58.3% and 94.4% for the ICM 2018 value. Our findings indicate that plasma D‐dimers have potential as markers of knee PJI, but moderate to low value for hip PJI.
Home Parenteral Nutrition Patient‐Reported Outcome Questionnaire: Sensitive to Quality of Life Differences Among Chronic and Prolonged Acute Intestinal Failure Patients
Authors: Winkler Marion F. , Machan Jason T. , Xue Zhigang , Compher Charlene 
Published: October 2020

AbstractBackgroundPatient‐reported outcome (PRO) measures often address quality of life (QOL) and help improve communication and shared decision‐making. The home parenteral nutrition patient‐reported outcome questionnaire (HPN‐PROQ) was developed for patients to self‐assess factors that influence QOL. The aim of this study was to establish construct validity.MethodResponses were analyzed for 77 HPN‐dependent patients with chronic and prolonged acute intestinal failure. General linear modeling was conducted to describe patterns of interactions and association between items included in the HPN‐PROQ.ResultsMost patients (78%) had chronic intestinal failure. Mean HPN duration was 3.3 ± 0.6 years. Underlying illness had a moderate or major effect on QOL for 88%; 59% reported their QOL had been negatively impacted by HPN. There was no difference in QOL among chronic patients, depending on how important they rated “being able to do what I want to do” (P = .1), whereas prolonged acute intestinal failure patients had significantly lower QOL if they rated “being able to do what I want to do” extremely vs very important (adjusted P = .02). Confidence with ability to perform HPN procedures was associated with understanding the need for HPN (P < .01). As ratings increased for emotional difficulty in coping with HPN so did HPN impact on QOL (linear trend P < .01).ConclusionConstruct validity of the HPN‐PROQ was evident. The HPN‐PROQ considers the unique experience of living with a complex nutrition therapy.
Wide‐viewing integral imaging display using rectangular light sources
Authors: Xiao Ju‐Lan , Wu Fei 
Published: October 2020

AbstractWe propose a wide‐viewing integral imaging display. It consists of an organic light‐emitting diode, a barrier array, and a liquid crystal panel. The organic light‐emitting diode generates the rectangular light sources, and the liquid crystal panel displays the elemental images. The barriers are introduced to separate adjacent rectangular light sources and corresponding elemental images. Lights emitting from the rectangular light sources only illuminate the corresponding elemental images. The horizontal viewing angle and the luminance are both enhanced by increasing the horizontal width of the point light source. A prototype of the proposed integral imaging display is developed, and the experiment results agree well with the theory.
Predicting Factors for Oncological and Functional Outcome in Hypopharyngeal Cancer
Authors: Visini Miranda , Giger Roland , Shelan Mohamed , Elicin Olgun , Anschuetz Lukas 
Published: October 2020

Objectives/HypothesisHypopharyngeal squamous cell carcinoma (SCC) is a rare but aggressive malignancy, with low survival rates and high incidence of tumor and treatment‐related morbidity. This study aims to analyze the long‐term oncologic and functional outcomes of a large cohort of patients and to determine prognostic factors.Study DesignRetrospective cohort study.MethodsThe records of all patients diagnosed with hypopharyngeal SCC and treated with curative intent at our tertiary referral center were reviewed. Patient and initial disease characteristics, features, and complications of primary treatment, recurrence patterns, and corresponding treatments and the oncologic and functional long‐term outcome were determined.ResultsFor a total of 179 patients, primary radiotherapy (RT) was the predominant treatment modality (78%), whereas 22% underwent primary surgery. The median, 2‐year, and 5‐year overall survival (OS) for the study cohort were 47 months, 64% and 43%. The median survival after first and second relapse was 7 and 6 months, respectively. The 2 and 5‐year relapse‐free survival (RFS) was 52% and 36%. The median RFS after first relapse and salvage treatment was 9 months. A nodal status of ≥cN2 (HR = 1.89, CI:1.21–3.05, P < .005) and any other primary tumor localization than pyriform sinus (HR = 1.60, CI: 1.04–2.42, P < .05) were identified as independent risk factors for shorter OS and RFS. Regarding functional outcome, the 2‐ and 5‐year laryngectomy‐free‐survival was 55% and 37%, respectively.ConclusionsIn this large cohort with long‐term follow‐up, any other primary tumor localization than pyriform sinus and a nodal status of ≥cN2 were identified as risk factors for reduced OS and RFS.Level of Evidence4 Laryngoscope, 131:E1543–E1549, 2021
Unilateral Sialendoscopy for Juvenile Recurrent Parotitis: What Happens to the Other Side?
Authors: Iordanis Konstantinidis , Panagiotis Dogantzis , Angelos Chatziavramidis , Antonios Metzikofis , Alexander Delides , Sofia Alataki , Efimia Papadopoulou‐Alataki 
Published: October 2020

Objective/HypothesisCurrent literature has confirmed the benefits of sialendoscopy for the treatment of juvenile recurrent parotitis (JRP). However, this procedure is often performed unilaterally, although the disease can affect both sides. This article investigated the clinical course of the contralateral parotid (CL) gland in children requiring unilateral sialendoscopy with the goal of clarifying the necessity of primary bilateral sialendoscopy.Study DesignProspective cohort study in a tertiary center.MethodsOver an eight‐year period, 77 children with JRP underwent unilateral sialendoscopy. We observed the clinical course of the CL parotid over a minimum follow‐up period of 24 months. New episodes of sialadenitis were recorded on both sides along with the need for a second sialendoscopy. These data were correlated with the preoperative symptoms of the contralateral side as well as ultrasound (U/S) findings at baseline assessment.ResultsIn total, six children required sialendoscopy on the CL side (7.8%), 62 children remained asymptomatic or with scarce swellings (80.5%), and nine children improved (11.7%). The preoperative U/S findings on the CL side positively correlated with the number of postoperative swellings. The proportion of children needing CL sialendoscopy was higher (21.4%) among children needing a second sialendoscopy on the operated side.ConclusionsIn the long term, the vast majority of children needing unilateral sialendoscopy do not require similar treatment of the CL parotid gland. However, a history of bilateral swellings along with U/S findings of parenchymal disorganization on the CL side significantly increases the risk of needing further sialendoscopy at a later time.Level of Evidence4 Laryngoscope, 131:1404–1409, 2021
Characteristics of Early Internal Laryngeal Muscle Atrophy After Recurrent Laryngeal Nerve Injuries in Rats
Authors: Wang Hong , Wang Haizhou , Li Xueyan , Xu Wen 
Published: October 2020

Objectives/HypothesisThe present study investigated the characteristics of early internal laryngeal muscle atrophy in recurrent laryngeal nerve injury (RLNI) rats.Study DesignTo observe the characteristics of early internal laryngeal muscle atrophy post RLNI.MethodsRats were divided into three groups: sham‐operated control group (n = 20), recurrent laryngeal nerve transverse injury group (RLNTI, n = 50), and recurrent laryngeal nerve blunt contusion group (RLNBC, n = 50). Five weeks after RLNI, certain rats were sacrificed weekly, and their laryngeal tissues were harvested. The atrophic features of internal laryngeal muscles were detected using hematoxylin and eosin. NF‐κB and MuRF‐1 levels were tested using IHC.ResultsThe atrophic degree and fibrosis of thyroarytenoid, posterior cricoarytenoid, and lateral cricoarytenoid muscles were related to the type of RLNI. The average myofiber cross‐sectional areas increased before an obvious decrease in the RLNTI and RLNBC groups. Muscle recovery occurred in the RLNBC group starting 4 weeks after RLNI, but only a weak trend was observed in the RLNTI group in the 5th week. During the muscle atrophy process, MuRF‐1 and NF‐κB were upregulated early and were maintained at a high level, which showed a trend similar to muscle atrophy. However, NF‐κB expression was opposite to MuRF‐1 expression and muscle atrophy when the muscles recovered.ConclusionThe atrophy degree of internal laryngeal muscles was associated with the type of RLNI. The NF‐κB/MuRF‐1 signaling pathway was involved in internal laryngeal muscle atrophy after RLNI, which is different from skeletal muscle after denervation.Level of EvidenceNA Laryngoscope, 131:E1256–E1264, 2021
Liver Transplantation Using Hepatitis C Virus–Viremic Donors Into Hepatitis C Virus–Aviremic Recipients as Standard of Care
Authors: Bohorquez Humberto , Bugeaud Emily , Bzowej Natalie , Scheuermann Jennifer , Hand Jonathan , Bruce David , Carmody Ian , Cohen Ari , Joshi Shobha , Seal John , Sonnier Dennis , Therapondos George , Girgrah Nigel , Anders Stephanie , Loss George E. 
Published: October 2020

Liver transplantation (LT) using allografts from hepatitis C virus (HCV)‐viremic/nucleic acid testing–positive donors’ (DNAT+) organs into HCV‐aviremic recipients (rHCV−) has been limited owing to nearly universal HCV transmission and concerns regarding availability, safety, and efficacy post‐LT with direct‐acting antiviral (DAA) therapy. We report our experience of LT using DNAT+ organs into rHCV− as a routine standard of care. Following verification of DAA access, absence of critical drug‐drug interactions (DDIs) with DAAs, and informed consent, allocated DNAT+ organs were offered to patients on the waiting list for LT irrespective of recipient HCV status. Between June 2018 and December 2019, 292/339 rHCV− received an LT. Forty‐seven patients were excluded from analysis because of recipient HCV viremia, refusal to receive DNAT+ organs, or inability to receive DAA therapy post‐LT. Of these 292 patients, 61 rHCV− received DNAT+ livers (study group), and 231 rHCV− received DNAT− (aviremic donors [nuclear acid test‐negative donors]) livers (control group). Recipient and donor characteristics as well as 1‐year post‐LT patient and graft survival were similar between groups. In the study group, 4 patients died, and 1 patient required retransplantation within the first year post‐LT (all unrelated to HCV); 56 patients received DAA therapy, with a median time from LT to the start of DAA treatment of 66.9 days (interquartile range [IQR], 36‐68.5), and 51 patients completed DAA treatment, all achieving sustained virologic response for 12 or more weeks (SVR‐12) (1 patient required retreatment owing to relapse following initial DAA therapy). No patients had evidence of fibrosing cholestatic hepatitis or extrahepatic manifestations of HCV. This report indicates that transplantation of DNAT+ livers into rHCV− and subsequent DAA therapy is associated with clinical outcomes comparable to those achieved with DNAT− allografts.
Triple‐Phase Computed Tomography May Replace Dual‐Energy X‐ray Absorptiometry Scan for Evaluation of Osteoporosis in Liver Transplant Candidates
Authors: Izzy Manhal , Addissie Benyam D. , Arab Juan Pablo , Hilscher Moira B. , Cartee Amanda , Lee David C. , Lee Yong , Fletcher Joel G. , Keaveny Tony M. , Sanchez William 
Published: October 2020

Assessment of bone density is an important part of liver transplantation (LT) evaluation for early identification and treatment of osteoporosis. Dual‐energy X‐ray absorptiometry (DXA) is currently the standard clinical test for osteoporosis; however, it may contribute to the appointment burden on LT candidates during the cumbersome evaluation process, and there are limitations affecting its accuracy. In this study, we evaluate the utility of biomechanical analysis of vertebral images obtained during dual‐energy abdominal triple‐phase computed tomography (TPCT) in diagnosing osteoporosis among LT candidates. We retrospectively reviewed cases evaluated for LT between January 2017 and March 2018. All patients who underwent TPCT within 3 months of DXA were included. The biomechanical computed tomography (BCT) analysis was performed at a centralized laboratory (O.N. Diagnostics, Berkeley, CA) by 2 trained analysts blinded to the DXA data. DXA‐based osteoporosis was defined as a T score ≤−2.5 at the hip or spine. BCT‐based osteoporosis was defined as vertebral strength ≤4500 N for women or ≤6500 N for men or trabecular volumetric bone mineral density ≤80 mg/cm3. Comparative data were available for 91 patients who had complete data for both DXA and BCT: 31 women and 60 men, age 54 ± 11 years (mean ± standard deviation), mean body mass index 28 ± 6 kg/m2. Using DXA as the clinical reference, sensitivity of BCT to detect DXA‐defined osteoporosis was 83.3% (20/24 patients) and negative predictive value was 91.7%; specificity and positive predictive value were 65.7% and 46.5%, respectively. BCT analysis of vertebral images on triple‐phase computed tomography, routinely obtained during transplant evaluation, can reliably rule out osteoporosis in LT candidates. Patients with suspicion of osteoporosis on TPCT may need further evaluation by DXA.
Telling a different story: How nonprofit organizations reveal strategic purpose through storytelling
Authors: Mitchell Sarah‐Louise , Clark Moira 
Published: October 2020

AbstractResponding to a call for research into storytelling within the nonprofit context, the paper contributes to an emerging research conversation about communicating organizational strategy through storytelling. The research analyses one hundred stories across 10 leading organizations to identify how they are being deployed and what that tells us about the underpinning strategy. Through bringing story character, classification, and content together for the first time, the paper presents a holistic perspective on the story construct. It identifies that, when viewed as a whole, the stories told by organizations can be a powerful communication tool for reaching external audiences. However, the research also identifies that their ability to convey strategic purpose through storytelling is moderated by storytelling capability. It finds that organizations with stronger storytelling capability use this craft to differentiate themselves more effectively. It concludes with contributing a new conceptual model for understanding organizational storytelling and a roadmap for practitioners to strengthen storytelling capability.
The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease
Authors: Ye Zheng , Zhang Guanyu , Zhang Yingshuang , Li Shuaiqi , Liu Na , Zhou Xiaolin , Xiao Weizhong , Münte Thomas F. 
Published: October 2020

ABSTRACTBackgroundDeficits in maintaining and manipulating sequential information online can occur even in patients with mild Parkinson's disease. The subthalamic nucleus may play a modulatory role in the neural system for sequential working memory, which also includes the lateral prefrontal cortex.ObjectivesThe objective of this study was to investigate neural markers of sequential working memory deficits in patients with de novo Parkinson's disease.MethodsA total of 50 patients with de novo Parkinson's disease and 50 healthy controls completed a digit ordering task during functional magnetic resonance imaging scanning. The task separated the maintenance (“pure recall”) and manipulation of sequences (“reorder & recall” vs “pure recall”).ResultsIn healthy controls, individual participants' task accuracy was predicted by the regional activation and functional connectivity of the subthalamic nucleus. Healthy participants who showed lower subthalamic nucleus activation and stronger subthalamic nucleus connectivity with the putamen performed more accurately in maintaining sequences (“pure recall”). Healthy participants who showed greater ordering‐related subthalamic nucleus activation change exhibited smaller accuracy costs in manipulating sequences (“reorder & recall” vs “pure recall”). Patients performed less accurately than healthy controls, especially in “reorder & recall” trials, accompanied by an overactivation in the subthalamic nucleus and a loss of synchrony between the subthalamic nucleus and putamen. Individual patients' task accuracy was predicted only by the subthalamic nucleus connectivity. The contribution of the subthalamic nucleus activation or activation change was absent. We observed no change in the lateral prefrontal cortex.ConclusionsThe overactivation and weakened functional connectivity of the subthalamic nucleus are the neural markers of sequential working memory deficits in de novo Parkinson's disease. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Salted and Unsalted Zhàcài (Brassica juncea var. tumida) Alleviated High‐Fat Diet‐Induced Dyslipidemia by Regulating Gut Microbiota: A Multiomics Study
Authors: Li Wenfeng , Chen Chunlian , Chen Mengting , Zhang Xiangyang , Ji Qin , Wang Yu , Zheng Qiaoran , Tan Si , Gao Xiaoxv , Lu Yalong 
Published: October 2020

ScopeZhàcài (ZC), a salting‐processed Brassica juncea var. tumida vegetable, is widely consumed as a pickle, but little is known about the health benefits of both salted and unsalted ZC as a whole food.Methods and ResultsThe preventive effects of salted and unsalted ZC against dyslipidemia are assessed in high‐fat (HF) diet‐fed mice. HF intake for 12 continuous weeks cause dyslipidemia in mice, as evidenced by the elevations in serum total triglyceride, total cholesterol, and low‐density lipoprotein cholesterol levels by 30%, 66%, and 117%, respectively. Metabolomics analysis and the 16S rRNA genes sequencing suggest that dietary administration of salted and unsalted ZC (2.5% w/w) alleviates HF‐induced dyslipidemia, metabolic disorders of short‐chain fatty acids, and disturbance of intestinal flora in mice. These positive effects of unsalted ZC are stronger than those of salted ZC. Moreover, fecal bacteria transplantation confirms the antidyslipidemia of ZC.ConclusionThese results suggest that consumption of ZC may prevent HF‐induced dyslipidemia by regulating gut microbiota.
Metabolic syndrome and peripheral neuropathy
Authors: Kazamel Mohamed , Stino Amro Maher , Smith Albert Gordon 
Published: October 2020

AbstractDiabetic peripheral neuropathy and metabolic syndrome (MetS) are both global health challenges with well‐established diagnostic criteria and significant impacts on quality of life. Clinical observations, epidemiologic evidence, and animal models of disease have strongly suggested MetS is associated with an elevated risk for cryptogenic sensory peripheral neuropathy (CSPN). MetS neuropathy preferentially affects small unmyelinated axons early in its course, and it may also affect autonomic and large fibers. CSPN risk is linked to MetS and several of its components including obesity, dyslipidemia, and prediabetes. MetS also increases neuropathy risk in patients with established type 1 and type 2 diabetes. In this review we present animal data regarding the role of inflammation and dyslipidemia in MetS neuropathy pathogenesis. Several studies suggest exercise‐based lifestyle modification is a promising treatment approach for MetS neuropathy.