bluuebunny/crossref_metadata_2025_split huggingface dataset:
Algebraic Flame Surface Density Modelling of High Pressure Turbulent Premixed Bunsen Flames
Authors: Rasool R. , Chakraborty N. , Klein M. 
Published: April 2020

AbstractPerformance of representative algebraic flame surface density (FSD) models have been a-priori assessed based on a direct numerical simulation database consisting of four turbulent premixed Bunsen flames at four different pressure levels. Results indicate that for a given resolution of the flame front, the considered algebraic FSD closures perform in a qualitatively similar manner irrespective of pressure variation. However, for a given computational mesh, the performance deteriorates as flame thickness decreases with increasing pressure. Additionally, the contribution of the subgrid scale surface-filtered density-weighted tangential diffusion component of the displacement speed tends to increase with pressure increment, further complicating the modelling of FSD. Further analysis also indicate that the inner cut-off scale normalized by the thermal flame thickness increases with increasing pressure, possibly due to the presence of Darrieus–Landau instability which is more likely to occur at higher pressure due to a larger ratio of hydrodynamic length scale to thermal flame thickness.
Mouse single oocyte imaging by MALDI-TOF MS for lipidomics
Authors: Bodzon-Kulakowska Anna , Arena Roberta , Mielczarek Przemyslaw , Hartman Kinga , Kozoł Paulina , Gibuła-Tarlowska Ewa , Wrobel Tomasz P. , Gąsior Łukasz , Polański Zbigniew , Ptak Grazyna E. , Suder Piotr 
Published: April 2020

AbstractReproductive cells are a very special kind of material for the analysis. Depending on the species, their dimensions allow for the application of mass spectrometry imaging-based techniques to receive a reasonable data for interpretation of their condition without any additional sample preparation steps, except for typical sample preparation characteristic for IMS protocols. A comparison between lipid profiles of oocytes could answer the question of the overall quality of the cells in the function of time or conditions of storage. Even tiny differences in the lipid profiles, but still detectable by bioinformatic analysis, could be crucial for the estimation of the conditions of the cells in various stages of development or aging. In our study, MALDI-TOF/TOF MSI was used to analyze and visualize the single oocytes. We deposited the cells on the transparent indium-tin-oxide (ITO) glass and marked their positions, which allowed for the fast localization of the cells and precise laser targeting in the ion source. We also optimized the usage of different MALDI matrices and different approaches. The proposed way of measurement allows analyzing quite a significant quantity of oocytes in a reasonably short time. During the analysis, the lipid composition of the single cell was successfully estimated in a conventional usage of the MALDI ion source, and the localization of lipids was confirmed by imaging mass spectrometry (IMS) analysis. The observed quantity of the lipids allowed for the application of the LIFT™ technique to obtain MS/MS spectra sufficient for lipids’ unambiguous identification. We hope that our idea of the oocyte analysis will help to elucidate chemical changes that accompany different processes in which oocytes are involved. There could be such fascinating phenomena as the oocyte maturation, changes in the lipid components during their storage, and much more.
“For Me, the Anorexia is Just a Symptom, and the Cause is the Autism”: Investigating Restrictive Eating Disorders in Autistic Women
Authors: Brede Janina , Babb Charli , Jones Catherine , Elliott Mair , Zanker Cathy , Tchanturia Kate , Serpell Lucy , Fox John , Mandy Will 
Published: April 2020

AbstractAutistic women are overrepresented among people in treatment for Anorexia Nervosa (AN). The current study aimed to: (1) better understand how AN develops and persists in autistic individuals from the perspective of autistic women, parents and healthcare professionals; (2) derive a theoretical model of restrictive eating difficulties in autism. We conducted 44 semi-structured interviews and used Thematic Analysis to identify patterns of meaning across the data. Themes related to sensory sensitivities, social interaction and relationships, sense of self and identity, difficulties with emotions, thinking styles, and a need for control and predictability. We developed a model of potential autism-specific mechanisms underlying restrictive eating difficulties. This study generated novel insights, which have the potential to inform treatment adaptations following empirical testing.
Low impact of two LED colors on nocturnal insect abundance and bat activity in a peri-urban environment
Authors: Bolliger Janine , Hennet Tom , Wermelinger Beat , Blum Stephan , Haller Jörg , Obrist Martin K. 
Published: April 2020

AbstractArtificial light at night (ALAN) is an important driver of change in ecological environments of the 21th century. We investigated the impact on nocturnal insect abundance and bat activity of two LED light colors (warm-white 2700 K, cold-white 6500 K) in a peri-urban environment. Bat activity (predominantly Pipistrellus pipistrellus) was largely driven by prey availability (insects), while insect abundance was responsive to nightly weather conditions (precipitation, temperature). Thus, both insects and bats were not differentially responsive to cold-white or warm-white LEDs. These findings are largely in contrast with literature, particularly for insects. However, as most published experiments on ALAN were conducted in areas that were lit solely for the purpose of the experiment, we would like to bring forward that (1) adaptation to environmental constraints may play a role in peri-urban environments that have been exposed to ALAN for many decades; or (2) impacts of cold-white LEDs on nocturnal insects may be lower than expected, because nocturnal insects adapted to low-light conditions may be put off by cold white light sources (6500 K).
Behavioural and Electrophysiological Responses of Female Anopheles gambiae Mosquitoes to Volatiles from a Mango Bait
Authors: Meza Felician C. , Roberts Joe M. , Sobhy Islam S. , Okumu Fredros O. , Tripet Frederic , Bruce Toby J. A. 
Published: April 2020

AbstractAttractive Toxic Sugar Baits (ATSB) are used in a “lure-and-kill” approach for management of the malaria vector Anopheles gambiae, but the active chemicals were previously unknown. Here we collected volatiles from a mango, Mangifera indica, juice bait which is used in ATSBs in Tanzania and tested mosquito responses. In a Y-tube olfactometer, female mosquitoes were attracted to the mango volatiles collected 24–48 h, 48–72 h and 72–96 h after preparing the bait but volatiles collected at 96–120 h were no longer attractive. Volatile analysis revealed emission of 23 compounds in different chemical classes including alcohols, aldehydes, alkanes, benzenoids, monoterpenes, sesquiterpenes and oxygenated terpenes. Coupled GC-electroantennogram (GC-EAG) recordings from the antennae of An. gambiae showed robust responses to 4 compounds: humulene, (E)-caryophyllene, terpinolene and myrcene. In olfactometer bioassays, mosquitoes were attracted to humulene and terpinolene. (E)-caryophyllene was marginally attractive while myrcene elicited an avoidance response with female mosquitoes. A blend of humulene, (E)-caryophyllene and terpinolene was highly attractive to females (P < 0.001) when tested against a solvent blank. Furthermore, there was no preference when this synthetic blend was offered as a choice against the natural sample. Our study has identified the key compounds from mango juice baits that attract An. gambiae and this information may help to improve the ATSBs currently used against malaria vectors.
Evaluating for Differences by Race/Ethnicity in the Association Between Income and Gambling Disorder
Authors: Day Brendan , Rosenthal Geoffrey , Adetunji Fiyinfolu , Monaghan Andrea , Scheele Christina , Tracy J. Kathleen 
Published: April 2020

AbstractMultiple studies show an increased prevalence of gambling disorder among African Americans compared to whites. However, few studies take an analytic approach to understanding differences in risk factors by race/ethnicity. Income is inversely associated with gambling disorder; we hypothesized that this association would vary by race/ethnicity. The main objective was to evaluate whether the association between income and gambling disorder varies by race/ethnicity. With data from the baseline visit of a prospective cohort study, Prevention and Etiology of Gambling Addiction Study in the United States, we used multivariable logistic regression analysis to determine whether the association between income and gambling disorder varies by race/ethnicity. 1164 participants were included in the final analyses. Measures included: demographics (age, sex, race/ethnicity, education, employment, annual household income), veteran status, marital status, homelessness, smoking, substance abuse, alcohol abuse, marijuana use, and lifetime gambling disorder diagnosis as derived from Alcohol Use Disorder and Associated Disabilities Interview Schedule. There was no evidence of effect modification by race/ethnicity in the association between income and gambling disorder (global p value = 0.17). Income was associated with increased odds of gambling disorder, but only for those with low income (< $15,000; OR 2.27, 95% CI 1.46, 3.53). There was no evidence that the effect of income on gambling disorder varies by race/ethnicity. For all race/ethnicities combined, low income was associated with significantly increased odds of gambling disorder (OR 2.27, 95% CI 1.46, 3.53). Further research is needed to better understand racial/ethnic differences in gambling disorder.
Persistent organic pollutants in wood fiber–contaminated sediments from the Baltic Sea
Authors: Dahlberg Anna-Karin , Apler Anna , Vogel Lisa , Wiberg Karin , Josefsson Sarah 
Published: April 2020

Abstract
Purpose
Many coastal areas in the Baltic Sea are contaminated with wood fiber and pollutants from pulp and paper industries. These anthropogenic, organic-rich, sediments (fiberbanks) have not been characterized and knowledge about their role as secondary sources for dispersal of persistent organic pollutants (POPs) is limited. Hence, the aim of this study was to elucidate the fate of POPs and the relationships between sorption (KD and KTOC), sediment type, and compound hydrophobicity (KOW) in fiber-contaminated sediments.

Materials and methods
Paired sediment and pore water samples (n = 24 sites) from three fiber-contaminated areas, located in the Ångermanälven river estuary in northern Sweden, were analyzed for POPs (viz. PCBs, DDT, and HCB) in sediment types representing different fiber content (i.e., fiberbanks, fiber-rich sediments, and natural less fiber impacted sediments). The freely dissolved concentration in sediment pore water was determined by sediment-polyoxymethylene (POM) partitioning. Instrumental analysis was performed using gas chromatography coupled to a triple quadrupole mass spectrometer (GC-MS/MS).

Results and discussion
Higher levels of total organic carbon (TOC) were found in the fiberbank sediment (range 8.6–37%) than in fiber-rich sediment (range 2.0–6.5%) and more natural sediment (range 2.0–2.9%). The sediment concentrations of POPs (dry weight basis) were also found to be significantly (p < 0.05) elevated in fiberbanks compared to the other sediment types. The fraction of DDD (48–66% of Σ6DDX) was larger in fiberbanks than in the other sediment types, likely due to anoxic conditions favoring reductive dechlorination of DDT. When sediment levels were normalized to TOC, HCB displayed similar levels across sediment type, suggesting a more diffuse source pattern than for PCB and DDT. Although significantly higher sorption (KD) of POPs was observed in fiberbanks, pore water levels were still elevated due to high bulk concentrations.

Conclusions
This study shows that fiberbanks are coastal hot spots for POPs in the Baltic Sea and that the levels are of ecotoxicological concern. Although the POPs are more strongly sorbed (KD) to this type of organic rich sediment, the high pore water concentrations in fiberbanks compared to the other sediment types investigated show that the risk of contaminant dispersal via pore water is elevated for fiberbanks.
Corona-Krise
Authors: Scherr Albert 
Published: April 2020

ZusammenfassungDer Beitrag setzt sich mit der Frage auseinander, was den gesellschaftlichen Reaktionen auf die Ausbreitung des Coronavirus zu Grunde liegt. In einer sozialwissenschaftlichen Perspektive wird argumentiert, dass diese nicht zureichend als zwangsläufige politische Konsequenz aus Einsichten der medizinischen Virenforschung verstanden werden können, sondern auch als Folge einer fundamentalen kulturellen Verunsicherung in den Blick zu nehmen sind. Aufgezeigt wird zudem die nationalistische Rahmung der politischen Reaktionen. Abschließend wird darauf auf die Gefahr hingewiesen, dass das, was in einem deklarierten temporären Ausnahmezustand gesellschaftlich durchsetzbar ist, auch unter anderen Bedingungen aktualisiert werden könnte.
Five Years Beyond Sendai—Can We Get Beyond Frameworks?
Authors: Wisner Ben 
Published: April 2020

AbstractThe Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR) and its implementation is evaluated after its first five years. A dozen questions that the author and a colleague used in their evaluation of the Hyogo Framework for Action 2005–2015 (HFA) are repeated. Improvements are noted in relation to possible coherence and alignment with other components of the Post-2015 Agenda, especially as regards climate change and urban disasters as well as the higher visibility of civil society and women, and also regarding the specificity of targets and monitoring of governments’ successes. Nevertheless, the overall conclusion is that both the HFA and the SFDRR fail to deal with root causes of disaster. A new, radically proactive leadership role is suggested for the United Nations Office for Disaster Risk Reduction in partnership with civil society in identifying and warning all engaged in Post-2015 Agenda activities of possible creation of new risk by agenda implementation activities, especially for the poor and already-marginalized.
Student perspectives on competency-based portfolios: Does a&nbsp;portfolio reflect their competence development?
Authors: Pool Andrea Oudkerk , Jaarsma A. Debbie C. , Driessen Erik W. , Govaerts Marjan J. B. 
Published: April 2020

Introduction Portfolio-based assessments require that learners’ competence development is adequately reflected in portfolio documentation. This study explored how students select and document performance data in their portfolios and how they perceive these data to be representative for their competence development.
Methods Students uploaded performance data in a competency-based portfolio. During one clerkship period, twelve students also recorded an audio diary in which they reflected on experiences and feedback that they perceived to be indicants of their competence development. Afterwards, these students were interviewed to explore the extent to which the performance documentation in the portfolio corresponded with what they considered illustrative evidence of their development. The interviews were analyzed using thematic analysis.
Results Portfolios provide an accurate but fragmented picture of student development. Portfolio documentation was influenced by tensions between learning and assessment, student beliefs about the goal of portfolios, student performance evaluation strategies, the learning environment and portfolio structure.
Discussion This study confirms the importance of taking student perceptions into account when implementing a competency-based portfolio. Students would benefit from coaching on how to select meaningful experiences and performance data for documentation in their portfolios. Flexibility in portfolio structure and requirements is essential to ensure optimal fit between students’ experienced competence development and portfolio content.
QTY Code-designed Water-soluble Fc-fusion Cytokine Receptors Bind to their Respective Ligands
Authors: Hao Shilei , Jin David , Zhang Shuguang , Qing Rui 
Published: April 2020

AbstractCytokine release syndrome (CRS), or ‘cytokine storm’, is the leading side effect during chimeric antigen receptor (CAR)-T therapy that is potentially life-threatening. It also plays a critical role in viral infections such as Coronavirus Disease 2019 (COVID-19). Therefore, efficient removal of excessive cytokines is essential for treatment. We previously reported a novel protein modification tool called the QTY code, through which hydrophobic amino acids Leu, Ile, Val and Phe are replaced by Gln (Q), Thr (T) and Tyr (Y). Thus, the functional detergent-free equivalents of membrane proteins can be designed. Here, we report the application of the QTY code on six variants of cytokine receptors, including interleukin receptors IL4Rα and IL10Rα, chemokine receptors CCR9 and CXCR2, as well as interferon receptors IFNγR1 and IFNλR1. QTY-variant cytokine receptors exhibit physiological properties similar to those of native receptors without the presence of hydrophobic segments. The receptors were fused to the Fc region of immunoglobulin G (IgG) protein to form an antibody-like structure. These QTY code-designed Fc-fusion receptors were expressed in Escherichia coli and purified. The resulting water-soluble fusion receptors bind to their respective ligands with Kd values affinity similar to isolated native receptors. Our cytokine receptor–Fc-fusion proteins potentially serve as an antibody-like decoy to dampen the excessive cytokine levels associated with CRS and COVID-19 infection.
Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells
Authors: Park Ji Hye , Lee Na Kyoung , Lim Hye Ji , Ji Seung taek , Kim Yeon-Ju , Jang Woong Bi , Kim Da Yeon , Kang Songhwa , Yun Jisoo , Ha Jong seong , Kim Hyungtae , Lee Dongjun , Baek Sang Hong , Kwon Sang-Mo 
Published: April 2020

AbstractThe mammalian target of rapamycin (mTOR) signaling pathway efficiently regulates the energy state of cells and maintains tissue homeostasis. Dysregulation of the mTOR pathway has been implicated in several human diseases. Rapamycin is a specific inhibitor of mTOR and pharmacological inhibition of mTOR with rapamycin promote cardiac cell generation from the differentiation of mouse and human embryonic stem cells. These studies strongly implicate a role of sustained mTOR activity in the differentiating functions of embryonic stem cells; however, they do not directly address the required effect for sustained mTOR activity in human cardiac progenitor cells. In the present study, we evaluated the effect of mTOR inhibition by rapamycin on the cellular function of human cardiac progenitor cells and discovered that treatment with rapamycin markedly attenuated replicative cell senescence in human cardiac progenitor cells (hCPCs) and promoted their cellular functions. Furthermore, rapamycin not only inhibited mTOR signaling but also influenced signaling pathways, including STAT3 and PIM1, in hCPCs. Therefore, these data reveal a crucial function for rapamycin in senescent hCPCs and provide clinical strategies based on chronic mTOR activity.
Biological sex classification with structural MRI data shows increased misclassification in transgender women
Authors: Flint Claas , Förster Katharina , Koser Sophie A. , Konrad Carsten , Zwitserlood Pienie , Berger Klaus , Hermesdorf Marco , Kircher Tilo , Nenadic Igor , Krug Axel , Baune Bernhard T. , Dohm Katharina , Redlich Ronny , Opel Nils , Arolt Volker , Hahn Tim , Jiang Xiaoyi , Dannlowski Udo , Grotegerd Dominik 
Published: April 2020

AbstractTransgender individuals (TIs) show brain-structural alterations that differ from their biological sex as well as their perceived gender. To substantiate evidence that the brain structure of TIs differs from male and female, we use a combined multivariate and univariate approach. Gray matter segments resulting from voxel-based morphometry preprocessing of N = 1753 cisgender (CG) healthy participants were used to train (N = 1402) and validate (20% holdout N = 351) a support-vector machine classifying the biological sex. As a second validation, we classified N = 1104 patients with depression. A third validation was performed using the matched CG sample of the transgender women (TW) application sample. Subsequently, the classifier was applied to N = 26 TW. Finally, we compared brain volumes of CG-men, women, and TW-pre/post treatment cross-sex hormone treatment (CHT) in a univariate analysis controlling for sexual orientation, age, and total brain volume. The application of our biological sex classifier to the transgender sample resulted in a significantly lower true positive rate (TPR-male = 56.0%). The TPR did not differ between CG-individuals with (TPR-male = 86.9%) and without depression (TPR-male = 88.5%). The univariate analysis of the transgender application-sample revealed that TW-pre/post treatment show brain-structural differences from CG-women and CG-men in the putamen and insula, as well as the whole-brain analysis. Our results support the hypothesis that brain structure in TW differs from brain structure of their biological sex (male) as well as their perceived gender (female). This finding substantiates evidence that TIs show specific brain-structural alterations leading to a different pattern of brain structure than CG-individuals.
Cerebrospinal fluid endocannabinoid levels in Gilles de la Tourette syndrome
Authors: Müller-Vahl Kirsten R. , Bindila Laura , Lutz Beat , Musshoff Frank , Skripuletz Thomas , Baumgaertel Charlotte , Sühs Kurt-Wolfram 
Published: April 2020

AbstractGilles de la Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the presence of motor and vocal tics as well as psychiatric comorbidities such as attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), depression, and anxiety. The underlying cause of the disease is still unknown, but several lines of evidence suggest a paramount role of the dopaminergic system. Based on the clinical observation that cannabis-based medicine including cannabis and delta-9-tetrahydrocannabinol (THC, dronabinol) may improve TS, alternatively, an involvement of the endocannabinoid system (ECS) has been suggested. In this study we measured cerebrospinal fluid (CSF) levels of the two most important endocannabinoids “N”-arachidonoylethanolamine (AEA, anandamide) and 2-arachidonoylglycerol (2-AG), the endocannabinoid-like molecule palmitoyl ethanolamide (PEA), and the lipid arachidonic acid (AA) in a sample of adult patients with TS (n = 20) compared with controls (n = 19) using liquid-liquid lipid extraction and simultaneous quantification by liquid chromatography multiple reaction monitoring (LC/MRM). CSF levels of AEA (p = 0.0018), 2-AG (p = 0.0003), PEA (p = 0.02), and AA (p < 0.0001) were significantly increased in TS compared with controls. Levels of 2-AG correlated with the severity of comorbid ADHD (p < 0.01). This is the first study, demonstrating alterations in the ECS suggesting an involvement of this system in the pathophysiology of TS. It can be speculated that elevated endocannabinoid levels either represent secondary changes in order to compensate for alterations in other neurotransmitter systems such as the dopaminergic system, are simply an epiphenomenon or, alternatively, represent the primary cause of TS.