bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcomes after surgery for catastrophic epilepsy in infants: institutional experience and review of the literature
Authors: Ye Vincent C. , Shah Ashish H. , Sur Samir , Achua Justin K. , Wang Shelly , Ibrahim George M. , Bhatia Sanjiv , Ragheb John 
Published: April 2020

OBJECTIVEUncontrolled epilepsy is associated with serious deleterious effects on the neurological development of infants and has been described as “catastrophic epilepsy.” Recently, there has been increased emphasis on early surgical interventions to preserve or rescue neurodevelopmental outcomes in infants with early intractable epilepsy. The enthusiasm for early treatments is often tempered by concerns regarding the morbidity of neurosurgical procedures in very young patients. Here, the authors report outcomes following the surgical management of infants (younger than 1 year).METHODSThe authors performed a retrospective review of patients younger than 1 year of age who underwent surgery for epilepsy at Miami (Nicklaus) Children’s Hospital and Jackson Memorial Hospital between 1994 and 2018. Patient demographics, including the type of interventions, were recorded. Seizure outcomes (at last follow-up and at 1 year postoperatively) as well as complications are reported.RESULTSThirty-eight infants (median age 5.9 months) underwent a spectrum of surgical interventions, including hemispherectomy (n = 17), focal resection (n = 13), and multilobe resections (n = 8), with a mean follow-up duration of 9.1 years. Hemimegalencephaly and cortical dysplasia were the most commonly encountered pathologies. Surgery for catastrophic epilepsy resulted in complete resolution of seizures in 68% (n = 26) of patients, and 76% (n = 29) had a greater than 90% reduction in seizure frequency. Overall mortality and morbidity were 0% and 10%, respectively. The latter included infections (n = 2), infarct (n = 1), and immediate reoperation for seizures (n = 1).CONCLUSIONSSurgical intervention for catastrophic epilepsy in infants remains safe, efficacious, and durable. The authors’ work provides the longest follow-up of such a series on infants to date and compares favorably with previously published series.
Relationship between direct cortical stimulation and induced high-frequency activity for language mapping during SEEG recording
Authors: Cuisenier Pauline , Testud Bénédicte , Minotti Lorella , El Bouzaïdi Tiali Samuel , Martineau Laurence , Job Anne-Sophie , Trébuchon Agnès , Deman Pierre , Bhattacharjee Manik , Hoffmann Dominique , Lachaux Jean-Philippe , Baciu Monica , Kahane Philippe , Perrone-Bertolotti Marcela 
Published: April 2020

OBJECTIVE
The authors assessed the clinical relevance of preoperative task-induced high-frequency activity (HFA) for language mapping in patients with refractory epilepsy during stereoelectroencephalography recording. Although HFA evaluation was described as a putative biomarker of cognition, its clinical relevance for mapping language networks was assessed predominantly by studies using electrocorticography (ECOG).

METHODS
Forty-two patients with epilepsy who underwent intracranial electrode implantation during both task-induced HFA and direct cortical stimulation (DCS) language mapping were evaluated. The spatial and functional relevance of each method in terms of specificity and sensitivity were evaluated.

RESULTS
The results showed that the two methods were able to map classic language regions, and a large and bilateral language network was obtained with induced HFA. At a regional level, differences were observed between methods for parietal and temporal lobes: HFA recruited a larger number of cortical parietal sites, while DCS involved more cortical temporal sites. Importantly, the results showed that HFA predicts language interference induced by DCS with high specificity (92.4%; negative predictive value 95.9%) and very low sensitivity (8.9%; positive predictive value 4.8%).

CONCLUSIONS
DCS language mapping appears to be more appropriate for an extensive temporal mapping than induced HFA mapping. Furthermore, induced HFA should be used as a complement to DCS to preselect the number of stimulated sites during DCS, by omitting those reported as HFA−. This may be a considerable advantage because it allows a reduction in the duration of the stimulation procedure. Several parameters to be used for each method are discussed and the results are interpreted in relation to previous results reported in ECOG studies.
An altered posterior question-mark incision is associated with a reduced infection rate of cranioplasty after decompressive hemicraniectomy
Authors: Veldeman Michael , Daleiden Lorina , Hamou Hussam , Höllig Anke , Clusmann Hans 
Published: April 2020

OBJECTIVE
Performing a cranioplasty (CP) after decompressive craniotomy is a straightforward neurosurgical procedure, but it remains associated with a high complication rate. Surgical site infection (SSI), aseptic bone resorption (aBR), and need for a secondary CP are the most common complications. This observational study aimed to identify modifiable risk factors to prevent CP failure.

METHODS
A retrospective analysis was performed of all patients who underwent CP following decompressive hemicraniectomy (DHC) between 2010 and 2018 at a single institution. Predictors of SSI, aBR, and need for allograft CP were evaluated in a univariate analysis and multivariate logistic regression model.

RESULTS
One hundred eighty-six patients treated with CP after DHC were included. The diagnoses leading to a DHC were as follows: stroke (83 patients, 44.6%), traumatic brain injury (55 patients, 29.6%), subarachnoid hemorrhage (33 patients, 17.7%), and intracerebral hemorrhage (15 patients, 8.1%). Post-CP SSI occurred in 25 patients (13.4%), whereas aBR occurred in 32 cases (17.2%). An altered posterior question-mark incision, ending behind the ear, was associated with a significantly lower infection rate and CP failure, compared to the classic question-mark incision (6.3% vs 18.4%; p = 0.021). The only significant predictor of aBR was patient age, in which those developing resorption were on average 16 years younger than those without aBR (p < 0.001).

CONCLUSIONS
The primary goal of this retrospective cohort analysis was to identify adjustable risk factors to prevent post-CP complications. In this analysis, a posterior question-mark incision proved beneficial regarding infection and CP failure. The authors believe that these findings are caused by the better vascularized skin flap due to preservation of the superficial temporal artery and partial preservation of the occipital artery. In this trial, the posterior question-mark incision was identified as an easily and costless adaptable technique to reduce CP failure rates.
The Association of Osteoarthritis and Related Pain Burden to Incident Alzheimer’s Disease and Related Dementias: A Retrospective Cohort Study of U.S. Medicare Beneficiaries
Authors: Innes Kim E. , Sambamoorthi Usha 
Published: April 2020

Background: Emerging evidence suggests osteoarthritis (OA) and related symptom burden may increase risk for Alzheimer’s disease and related dementias (ADRD). However, longitudinal studies are sparse, and none have examined the potential mediating effects of mood or sleep disorders. Objective: To determine the association of OA and related pain to incident ADRD in U.S. elders. Methods: In this retrospective cohort study, we used baseline and two-year follow-up data from linked Medicare claims and Medicare Current Beneficiary Survey files (11 pooled cohorts, 2001–2013). The study sample comprised 16,934 community-dwelling adults≥65 years, ADRD-free at baseline and enrolled in fee-for-service Medicare. Logistic regression was used to assess the association of OA and related pain (back, neck, joint, neuropathic) to incident ADRD, explore the mediating inlfuence of mood and insomnia-related sleep disorders, and (sensitivity analyses) account for potential survival bias. Results: Overall, 25.5% of beneficiaries had OA at baseline (21.0% with OA and pain); 1149 elders (5.7%) were subsequently diagnosed with ADRD. Compared to beneficiaries without OA, those with OA were significantly more likely to receive a diagnosis of incident ADRD after adjustment for sociodemographics, lifestyle characteristics, comorbidities, and medications (adjusted odds ratio (AOR) = 1.23 (95% confidence interval (CI) 1.06, 1.42). Elders with OA and pain at baseline were significantly more likely to be diagnosed with incident ADRD than were those without OA or pain (AOR = 1.31, CI 1.08, 1.58). Sensitivity analyses yielded similar findings. Inclusion of depression/anxiety, but not sleep disorders, substantially attenuated these associations. Conclusion: Findings of this study suggest that: OA is associated with elevated ADRD risk, this association is particularly pronounced in those with OA and pain, and mood disorders may partially mediate this relationship.
Odor Identification Impairment and Change with Cholinesterase Inhibitor Treatment in Mild Cognitive Impairment
Authors: Devanand D. P. , Liu Xinhua , Chunga Richard E. , Cohen Hannah , Andrews Howard , Schofield Peter W. , Stern Yaakov , Huey Edward D. , Choi Jongwoo , Pelton Gregory H. 
Published: April 2020

Background: Anticholinergic challenge can induce odor identification impairment that indicates Alzheimer’s disease (AD) pathology, and short-term change in odor identification impairment with cholinesterase inhibitor (CheI) treatment may predict longer term cognitive outcomes. Objective: In patients with mild cognitive impairment (MCI) treated prospectively with donepezil, a CheI, for 52 weeks, to determine if 1) acute decline in odor identification ability with anticholinergic challenge can predict cognitive improvement, and 2) change in odor identification over 8 weeks can predict cognitive improvement. Methods: MCI was diagnosed clinically without AD biomarkers. At baseline, the University of Pennsylvania Smell identification Test (UPSIT) was administered before and after an anticholinergic atropine nasal spray challenge. Donepezil was started at 5 mg daily, increased to 10 mg daily if tolerated, and this dose was maintained for 52 weeks. Main outcomes were ADAS-Cog total score and Selective Reminding Test (SRT) total immediate recall score measured at baseline, 26 and 52 weeks. Results: In 100 study participants, mean age 70.14 (SD 9.35) years, atropine-induced decrease in UPSIT score at baseline was not associated with change in ADAS-Cog or SRT scores over 52 weeks. Change in UPSIT score from 0 to 8 weeks did not show a significant association with change in the ADAS-Cog or SRT measures over 52 weeks. Conclusion: These negative findings in a relatively large sample of patients with MCI did not replicate results in much smaller samples. Change in odor identification with anticholinergic challenge, and over 8 weeks, may not be useful predictors of cognitive improvement with CheI in patients with MCI.
The effect of different doses of probiotic feed additives on hematologic indices and morphological structure of individual pig internal organs
Authors: Zhyla M. , Shkodyak N. , Kotsyumbas G. , Stronskyi Y. , Sobodosh O. , Shkil M. 
Published: April 2020

In order to improve the digestibility and absorption of feed, metabolic processes, growth and development of animals, increase the resistance of the body immunomodulatory agents, probiotics, prebiotics, combined enzyme-probiotic feed additives are widely used. The purpose of our work was to conduct comparative clinical trials of the effectiveness of the probiotic feed additive Probion-forte in terms of productivity, blood indices and histological structure of individual internal pigs organs during fattening. The researches were carried out on 120 piglets of big white breed at the age of 28 days, which were divided into 4 groups with 30 units in each one. The probiotics were added to feed in different concentrations in order to determine their efficiency and examine influence on piglets organism: the first group was given probiotic Probion-forte in dose of 1.0 g/kg (10 weeks); the second one – Probion in dose of 1.0 g/kg (6 weeks) and 0.5 g/kg (4 weeks); the third one was given probiotic Bio Plus 2B in dose of 0.4 g/kg for 10 weeks; and the fourth one was a control group. The compound feed was provided according to norms recommended for big white breed taking into account age. On the 42nd day (6 weeks) and on the 70th day of test 10 units were selected for haematological, pathomorphological and microbiological tests. The productivity of animals of all studied groups was evaluated by the average daily gains, safety, feed conversion and slaughter output. The stabilized with EDTA piglets’ blood was used for morphological studies, and blood serum – for biochemical studies. The clinical trials have shown that the application of Probion-forte, as a feed additive for fattening of piglets within 10 weeks after weaning, did not cause adverse reactions, was well tolerated by animals and contributed to the improvement of the processes of erythropoiesis and leucopoiesis, increased of serum total protein content. The increasing activity of serum transaminases indicated more intense metabolic processes in experimental animals’ organism, which was confirmed by increase in average daily weight gains and slaughter output compared to control. In the microscopic examination of the thymus, spleen, lymph nodes, intestines, liver, the characteristic histological structure of the organs was preserved and indicated their active morphofunctional state throughout the study period. Morphometrically the increase in the height of the villi in the duodenum and the size of the thymus lobes in piglets, which were fed with probiotic feed additives was established. The efficiency and appropriateness of the application of these products was confirmed in the first and second experimental groups. However, the most significant difference was observed in piglets fed with Probion-forte for 10 weeks at a dose of 1.0 g/kg of feed.
Effects of probiotic Clostridium Butyrate on Performance and Immunocompetence and Digestive Function of poultry
Authors: Wang Xiaofei , Xu Yanzhao , Fotina Hanna 
Published: April 2020

The purpose of our research was to study the effects of dietary addition of Clostridium butyricum (CB) on performance, immunocompetence and digestive function of poultry. Using single factor experiment design, 720 one-day-old and healthy AA broilers were divided into 6 groups with 6 replicates in each group and 20 broilers in each replicate. Broilers in control group were fed a basal diet, while broilers of other experimental group were fed the basal diet supplemented with CB 250 mg/kg, 500 mg/kg, 750 mg/kg, 1000 mg/kg and 1250 mg/kg. The results showed as follows: The 1000mg/mg group had the best effect on immunity enhancement, with the thymus index, spleen index and bursa index increased by 18.38 % (P < 0.05), 16.00 % (P < 0.05) and 8.03 % (P > 0.05) in 1–21 days, and 6.45 % (P < 0.05), 12.92 % (P < 0.05) and 13.94 % (P < 0.05) in 22–49 days. The 1000 mg/kg group and 1250 mg/kg group had the best effect on improving the digestive function, with the VH/CD value increased by 27.56 % (P < 0.05) and 29.56 % (P < 0.05) in 1–21 days, and 29.48 % (P < 0.05) and 30.80 % (P < 0.05) in 22–49 days, with the number of harmful bacteria Escherichia coli and Salmonella decreased significantly (P < 0.05). These results indicated that the addition of CB in diets of broiler can improve the production performance, enhance immunity and improve digestive function, and the optimal dosage is 1000 mg/kg.
The influence of the preparation “Bendamin” on the morphological and biochemical indices of blood of rats in experimental modeling of heart failure
Authors: Varkholiak I. S. , Gutyj B. V. 
Published: April 2020

The purpose of this work was to study the influence of “Bendamin” on the morphological and biochemical indices of rat blood in experimental modeling of heart failure. The investigation were performed on white sexually mature young male-rats of Wistar line weighing 180–200 g, kept at the standard ration of the institute vivarium of the State Research Institute of Veterinary Preparations and Fodder Additives. To create a model of doxorubicin-induced cardiomyopathy, 24 male rats were selected. Animals were divided into 3 groups of 6 animals in each: control group – intact animals; experimental group E1, in which animals were modeled doxorubicin-induced cardiomyopathy by intraperitoneal injected of doxorubicin at a dose of 2.5 mg/kg 3 times a week for two weeks; experimental group E2, in which animals, after injection of doxorubicin, the preparation “Bendamin” was injected in the dose 20 mg/kg intragastrically. For experimental modeling of heart a decrease in the number of red blood cells was found in the blood of rats of the first experimental group by 34.7 % and hemoglobin level – by 24.2 %, with a simultaneous increase in the average hemoglobin content in one erythrocyte by 16.2 %. Doxorubicin-induced cardiomyopathy in rats of the first experimental group was accompanied by a decrease in leukocyte count by 22.2 %, an increase in uric acid level by almost in 2 times, creatinine by 11.4 %, cholesterol by 61.1 %. In the research of the protein synthesizing function of the liver of rats in experimental modeling of heart failure, a decrease in total protein by 9.6 % was found. These changes were accompanied by a slight decrease in albumin levels and a slight increase in globulin levels. By intoxication with doxorubicin, rats of the first experimental group showed a violation of the functional state of the liver, indicating an increase in the activity of aminotransferases in their blood, namely: AlAT by 34.2 %, AsAT – by 21.7 %, accordingly. Positive action of cardio preparation “Bendamin” on rats organism under conditions of creation of a model of doxorubicin-induced cardiomyopathy was installed, manifested by the normalization of hematological and biochemical parameters, functional status and protein synthesis of the liver.
Learning from Royal Shell’s Logistics and Supply Chain Management
Authors: AbdulGhani Gaghman  
Published: April 2020

The study is conducted to analysis the supply chain management paying special attention to the logistics. The aim is to understand the impact of logistics on organization performance, also to help in identifying opportunities for cost/time removals and/or value adding along the supply chain. The company chosen for the study is Royal Dutch Shell Plc. As Shell is the one of the big-gest Oil and Gas Company known in the world and one of the leaders of logistic and supply chain management. Though Shell is working efficiently for providing customers with quality services still there are is-sues with the supply chain which should be taken care of in order to be much better. These factors grouped in Control the Cost, Planning and Risk Management, Suppliers/Owners Relationship Management. Study concluded with some suggestions can be adopted by any organization aiming for better performance in supply chain.
A mão do carrasco: o impacto na saúde mental da população LGBT+ após o período eleitoral de 2018 no Brasil
Authors: Pessoa Brenna Galtierrez Fortes , Ferreira João Caio Silva Castro , Sousa Junior Paulo de Tarso Xavier , Monte Liana Maria Ibiapina do , Lando Giorge Andre , Nascimento Elaine Ferreira do , Oliveira Marcos Renato de 
Published: April 2020

O artigo tem por objetivo analisar o impacto na saúde mental da população LGBT+, após o período eleitoral de 2018 correlacionando com os principais fatos que ocorreram nesses três eixos: subjetividade, política e saúde. Com vista para entender os reflexos que causaram devido aos estigmas, discriminação, preconceito, bem como a ameaça contra os seus direitos sociais e humanos, estes conquistados à duras penas, durante o período eleitoral. A metodologia utilizada para este trabalho foi uma pesquisa de natureza qualitativa, desenvolvida na capital do Piauí, Teresina As informações foram coletadas por meio de entrevistas semiestruturada e analisadas a partir do método de interpretação dos sentidos realizada com Lésbicas, Gays, Bissexuais, Travetis e Transexuais (LGBT´s) independentemente de serem pessoas assumidas para seus familiares ou não, com idade igual ou acima de 18 anos, integrantes de algum movimento social sobre as causas LGBT e, que já tiveram concluído ou estejam cursando o ensino superior. Os resultados apontam como a figura de Jair Bolsonaro, contribuiu para legitimação de uma rede de discurso de ódio contra as “minorias sociais”, dentre eles os LGBTs, culminando assim em uma necropolítica ou política da morte.
Neoplasia maligna da próstata no Brasil: morbidade (2013-2018) e mortalidade (2008-2017)
Authors: Silva Daniel Augusto da 
Published: April 2020

Aos homens, o segundo tipo de neoplasia com a maior incidência e mortalidade é a neoplasia da próstata. O de maior incidência é a neoplasia da pele não melanoma e a primeira causa de mortalidade é a neoplasia de pulmão. O objetivo do estudo foi de elucidar os dados epidemiológicos sobre a morbidade e mortalidade por neoplasia maligna da próstata no Brasil. Trata-se de um estudo descritivo, retrospectivo, epidemiológico, de série histórica, de abordagem quantitativa, baseado em dados secundários, sobre a morbidade e mortalidade por neoplasia maligna da próstata, no Brasil. Os dados de morbidade e mortalidade por neoplasia maligna da próstata foram obtidos no mês de janeiro de 2020, nos bancos de dados brasileiros: Painel-Oncologia e Sistema de Informações sobre Mortalidade do Departamento de Informática do Sistema Único de Saúde (DATASUS). Dados sobre estimativas populacionais foram obtidos no Instituto Brasileiro de Geografia. O diagnóstico da neoplasia maligna da próstata aumentou consideravelmente no ano de 2018, um aumento de 39,3% entre 2017 e 2018. As regiões Sul e Sudeste, em todo o período analisado, apresentam coeficiente de incidência de neoplasia maligna da próstata maiores que o coeficiente nacional. Sobre a mortalidade por neoplasia maligna da próstata, no período de 10 anos, o Brasil registrou aumento de 15,6% nesta ocorrência, chegando a 7,4 mortes a cada 100 mil habitantes em 2017. É necessário investimento de estratégias que garantam o diagnóstico precoce, por meio da detecção precoce da neoplasia maligna da próstata.
Estrategias Financieras para mejorar las cuentas por cobrar en la Compañia Aquasport SAC
Authors: Morales García Analis Katy , Carhuancho Mendoza Irma Milagros 
Published: April 2020

La presente investigación tiene por objetivo proponer estrategias financieras para mejorar las cuentas por cobrar en la compañía Aquasport S.A.C. 2017-2018, de acuerdo a la metodología de proyección del estado de situación financiera, estado de ganancias y pérdidas y presupuestos, en los periodos 2020-2024, empezando con el análisis de los estados financieros de la compañía.
El estudio de investigación se realizó bajo el enfoque mixto, de la misma manera el sintagma fue holístico, el tipo de investigación fue proyectiva, del mismo modo el nivel fue comprensivo y el método fue deductivo, asimismo la población fue de 20 personas colaboradores de la compañía, seleccionando una muestra de 3 personas, trabajadores directos relacionados al tema de investigación, las técnicas que se usaron fueron entrevista y análisis documental, y los instrumentos fueron guía de entrevistas y guía de análisis documental, también los análisis de datos fue la aplicación de análisis vertical y horizontal, además los ratios de liquidez, solvencia, gestión, rentabilidad. Finalmente para la triangulación de datos se desarrolló mediante el software Atlas.ti.8.
Los resultados señalan que las cuentas por cobrar son deficientes, la compañía necesita reestructurar las políticas y procedimientos de cobranzas, realizar flujo de caja para controlar el efectivo, además la implementación de estrategias financieras para gestionar los cobros de manera eficiente, del mismo modo realizar presupuestos de ventas y cobranzas, de esta manera trabajar en base a objetivos, en conclusión lograr resultados eficientes.