bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immersive 3D Vehicle Simulation for Hardware-in-the-Loop Testing of Mobile Hydraulic Controls
Authors: Liermann Matthias , Feller Christian , Lindinger Florian , Runge Dirk 
Published: December 2019

Abstract
The paper presents a HiL test setup for hydraulic propel systems that includes a multi-body dynamic simulation of a vehicle in a realistic 3D environment. It allows testing of driving scenarios under load conditions that would otherwise be very difficult to obtain. The hydraulic-mechanical part of the simulation is modeled in Simulink. An open-source C++ physics engine is used to model the vehicle multi-body mechanics and collision detection between the vehicle and the 3D environment. Despite the high complexity of the hydraulic drive train component models, the constraint of real-time execution of the simulation on a real-time target can be fulfilled.
A Control Algorithm for Active/Passive Hydraulic Winches Used in Active Heave Compensation
Authors: Moslått Geir-Arne , Padovani Damiano , Hansen Michael R. 
Published: December 2019

Abstract
The most common active heave compensated offshore cranes have hydraulic winch systems. This paper investigates an active/passive hydraulic winch system with variable-displacement motors and variable-displacement pumps. The paper addresses the challenges when the active motors are set with a low displacement. The active motor displacement is shown to have significant impact on the dynamics of the closed loop hydraulic system. The classical control strategy for this type of system do not address these challenges and will in certain situations have significantly reduced performance. Therefor, a new control method is presented that utilize the variable displacement of the pumps and motors for speed control and to improve dynamics characteristics. The new winch controller is tested in a high-fidelity simulation model and is shown to improve low speed performance, reduce winch speed limitations by up to 30%, reduce system peak pressure by approximately 20%, and reduce control error by approximately 30%.
The Effects of Stabilization Exercise on the Thickness of Lateral Abdominal Muscles During Standing Tasks in Women With Chronic Low Back Pain: A Randomized Triple-Blinded Clinical Trial Study
Authors: Ehsani Fatemeh , Hedayati Rozita , Bagheri Rasool , Jaberzadeh Shapour 
Published: December 2019

Context: Chronic low back pain (CLBP) often presents with a dysfunction in deep abdominal muscles activity during standing tasks. Although some studies indicated that deep abdominal muscle activity improved during some functional tasks following stabilization exercise (SE), there is no study to evaluate the effect of SE on lateral abdominal muscles thickness during standing postural tasks. Objective: The purpose of this study was (1) to evaluate the lateral abdominal muscles thickness in the participants with CLBP while standing on a balance board and (2) to compare the effects of SE and a general exercise (GE) program on the lateral muscles thickness changes. Methods: This was a between-groups, triple-blinded randomized controlled trial design. In total, 40 females with CLBP were randomly assigned into 2 groups: GE (control group) and supervised progressive SE (experimental group). Diagnostic ultrasound imaging was used before and after the intervention to measure lateral abdominal muscles thickness during standing on 2 different levels of platform in the Biodex Balance System. Visual analog scale and Roland–Morris Disability Questionnaire were used to evaluate changes in pain intensity and disability. Results: The results indicated significant increases in transverse abdominis muscle thickness during all standing tasks (P = .02) and significant decreases in pain intensity and disability following SE intervention (P < .001). However, the lateral abdominal muscle thicknesses were not changed after GE intervention while standing postural tasks (P > .05). The GE group revealed only significant decreases in pain intensity after intervention (P = .03). Conclusion: Supervised progressive SE improved the activity of deep abdominal muscles in standing postural tasks in the patients with CLBP.
Acute Muscular Responses to Practical Low-Load Blood Flow Restriction Exercise Versus Traditional Low-Load Blood Flow Restriction and High-/Low-Load Exercise
Authors: Thiebaud Robert S. , Abe Takashi , Loenneke Jeremy P. , Garcia Tyler , Shirazi Yohan , McArthur Ross 
Published: December 2019

Context:Blood flow restriction (BFR) increases muscle size and strength when combined with low loads, but various methods are used to produce this stimulus. It is unclear how using elastic knee wraps can impact acute muscular responses compared with using nylon cuffs, where the pressure can be standardized.Objective:Investigate how elastic knee wraps compare with nylon cuffs and high-load (HL)/low-load (LL) resistance exercise.Design:A randomized cross-over experimental design using 6 conditions combined with unilateral knee extension.Setting:Human Performance Laboratory.Participants:A total of 9 healthy participants (males = 7 and females = 2) and had an average age of 22 (4) years.Intervention:LL (30% of 1-repetition maximum [1-RM]), HL (70% 1-RM), BFR at 40% of arterial occlusion pressure (BFR-LOW), BFR at 80% of arterial occlusion pressure (BFR-HIGH), elastic knee wraps stretched by 2 in (PRACTICAL-LOW), and elastic knee wraps stretched to a new length equivalent to 85% of thigh circumference (PRACTICAL-HIGH). BFR and practical conditions used 30% 1-RM.Main Outcome Measures:Muscle thickness, maximum voluntary isometric contraction, and electromyography amplitude. Bayesian statistics evaluated differences in changes between conditions using the Bayes factor (BF10), and median and 95% credible intervals were reported from the posterior distribution.Results:Total repetitions completed were greater for BFR-LOW versus PRACTICAL-HIGH (BF10 = 3.2, 48.6 vs 44 repetitions) and greater for PRACTICAL-LOW versus BFR-HIGH (BF10 = 717, 51.8 vs 36.3 repetitions). Greater decreases in changes in maximum voluntary isometric contraction were found in PRACTICAL-HIGH versus HL (BF10 = 1035, ∼103 N) and LL (BF10 = 45, ∼66 N). No differences in changes in muscle thickness were found between LL versus PRACTICAL-LOW/PRACTICAL-HIGH conditions (BF10 = 0.32). Greater changes in electromyography amplitude were also found for BFR-LOW versus PRACTICAL-HIGH condition (BF10 = 6.13, ∼12%), but no differences were noted between the other BFR conditions.Conclusions:Overall, elastic knee wraps produce a more fatiguing stimulus than LL or HL conditions and might be used as an alternative to pneumatic cuffs that are traditionally used for BFR exercise.
Soil Microbial Communities in Diverse Agroecosystems Exposed to the Herbicide Glyphosate
Authors: Kepler Ryan M. , Epp Schmidt Dietrich J. , Yarwood Stephanie A. , Cavigelli Michel A. , Reddy Krishna N. , Duke Stephen O. , Bradley Carl A. , Williams Martin M. , Buyer Jeffrey S. , Maul Jude E. 
Published: December 2019

Increasing the efficiency of food production systems while reducing negative environmental effects remains a key societal challenge to successfully meet the needs of a growing global population. The herbicide glyphosate has become a nearly ubiquitous component of agricultural production across the globe, enabling an increasing adoption of no-till agriculture. Despite this widespread use, there remains considerable debate on the consequences of glyphosate exposure. In this paper, we examine the effect of glyphosate on soil microbial communities associated with the roots of glyphosate-resistant crops. Using metabarcoding techniques, we evaluated prokaryotic and fungal communities from agricultural soil samples (
n
= 768). No effects of glyphosate were found on soil microbial communities associated with glyphosate-resistant corn and soybean varieties across diverse farming systems.
An abnormal finding in the third trimester
Authors: Marshall Hannah , Petrie Kyle 
Published: December 2019

A healthy woman presented with an antepartum haemorrhage at 35/40 during a low-risk pregnancy with normal antenatal bloods and anomaly scan at 20/40 gestation. Following an abnormal ultrasound (USS), the baby was delivered by emergency C-section.A male infant was born in good condition but admitted to the neonatal unit for monitoring. Examination revealed global hypotonia, a weak uncoordinated suck and absent Moro reflex. He had widened sagittal sutures and a large posterior fontanelle. The remainder of the examination was unremarkable. Abnormal bloods are shown in table 1 .Table 1Initial newborn blood resultsTestValueNormal rangeWhite cell count3.23×109/L10.0–26.0×109/LNeutrophils0.52×109/L1.0–8.5×109/LBilirubin221 µmol/L0–20 µmol/LGamma glutamyl transferase828 IU/L20–183 IU/LHe was treated for suspected sepsis due to jaundice and temperature instability.Cranial USS was performed immediately ( figure 1 ). Urgent MRI of the brain further characterised these abnormalities ( figures 2–3 ).Figure 1Coronal section of cranial ultrasound obtained on day 1 of life.Figure 2Coronal section from MRI performed on day 1 of life.Figure 3Sagittal section from MRI performed on day 1 of life.QuestionsWhat are the causes for the abnormalities seen in figures 1–3 ?What investigations should be considered?What is the diagnosis?How do we manage this condition?What are the likely outcomes?Answers can be found on page 2
Feasibility study for use of angiographic parametric imaging and deep neural networks for intracranial aneurysm occlusion prediction
Authors: Shiraz Bhurwani Mohammad Mahdi , Waqas Muhammad , Podgorsak Alexander R , Williams Kyle A , Davies Jason M , Snyder Kenneth , Levy Elad , Siddiqui Adnan , Ionita Ciprian N 
Published: December 2019

BackgroundAngiographic parametric imaging (API), based on digital subtraction angiography (DSA), is a quantitative imaging tool that may be used to extract contrast flow parameters related to hemodynamic conditions in abnormal pathologies such as intracranial aneurysms (IAs).ObjectiveTo investigate the feasibility of using deep neural networks (DNNs) and API to predict IA occlusion using pre- and post-intervention DSAs.MethodsWe analyzed DSA images of IAs pre- and post-treatment to extract API parameters in the IA dome and the corresponding main artery (un-normalized data). We implemented a two-step correction to account for injection variability (normalized data) and projection foreshortening (relative data). A DNN was trained to predict a binary IA occlusion outcome: occluded/unoccluded. Network performance was assessed with area under the receiver operating characteristic curve (AUROC) and classification accuracy. To evaluate the effect of the proposed corrections, prediction accuracy analysis was performed after each normalization step.ResultsThe study included 190 IAs. The mean and median duration between treatment and follow-up was 9.8 and 8.0 months, respectively. For the un-normalized, normalized, and relative subgroups, the DNN average prediction accuracies for IA occlusion were 62.5% (95% CI 60.5% to 64.4%), 70.8% (95% CI 68.2% to 73.4%), and 77.9% (95% CI 76.2% to 79.6%). The average AUROCs for the same subgroups were 0.48 (0.44–0.52), 0.67 (0.61–0.73), and 0.77 (0.74–0.80).ConclusionsThe study demonstrated the feasibility of using API and DNNs to predict IA occlusion using only pre- and post-intervention angiographic information.
Predicting the duration of sickness absence spells due to back pain: a population-based study from Sweden
Authors: Ropponen Annina , Gémes Katalin , Frumento Paolo , Almondo Gino , Bottai Matteo , Friberg Emilie , Alexanderson Kristina 
Published: December 2019

ObjectivesWe aimed to develop and validate a prediction model for the duration of sickness absence (SA) spells due to back pain (International Statistical Classification of Diseases and Related Health Problems 10th Revision: M54), using Swedish nationwide register microdata.MethodsInformation on all new SA spells >14 days from 1 January 2010 to 30 June 2012 and on possible predictors were obtained. The duration of SA was predicted by using piecewise constant hazard models. Nine predictors were selected for the final model based on a priori decision and log-likelihood loss. The final model was estimated in a random sample of 70% of the SA spells and later validated in the remaining 30%.ResultsOverall, 64 048 SA spells due to back pain were identified during the 2.5 years; 74% lasted ≤90 days, and 9% >365 days. The predictors included in the final model were age, sex, geographical region, employment status, multimorbidity, SA extent at the start of the spell, initiation of SA spell in primary healthcare and number of SA days and specialised outpatient healthcare visits from the preceding year. The overall c-statistic (0.547, 95% CI 0.542 to 0.552) suggested a low discriminatory capacity at the individual level. The c-statistic was 0.643 (95% CI 0.634 to 0.652) to predict >90 days spells, 0.686 (95% CI 0.676 to 0.697) to predict >180 spells and 0.753 (95% CI 0.740 to 0.766) to predict >365 days spells.ConclusionsThe model discriminates SA spells >365 days from shorter SA spells with good discriminatory accuracy.
Study of the dilepton electromagnetic decays of $$\chi _{cJ}(1P)$$
Authors: Wang Xuan-He , Jiang Yue , Wang Tianhong , Tan Xiao-Ze , Li Geng , Wang Guo-Li 
Published: December 2019

AbstractIn this paper, the dilepton electromagnetic decays $$\chi _{cJ}(1P) \rightarrow J/\psi e^+e^-$$χcJ(1P)→J/ψe+e- and $$\chi _{cJ}(1P) \rightarrow J\psi \mu ^+\mu ^-$$χcJ(1P)→Jψμ+μ-, where $$\chi _{cJ}$$χcJ denotes $$\chi _{c0}$$χc0, $$\chi _{c1}$$χc1 and $$\chi _{c2}$$χc2, are calculated systematically in the improved Bethe–Salpeter method. The numerical results of decay widths and the invariant mass distributions of the final lepton pairs are given. The comparison is made with the recently measured experimental data of BESIII. It is shown that for the cases including $$e^+e^-$$e+e-, the gauge invariance is decisive and should be considered carefully. For the processes of $$\chi _{cJ}(1P) \rightarrow J/\psi e^+e^-$$χcJ(1P)→J/ψe+e-, the branching fraction are: $$\mathcal {B}[\chi _{c0}(1P) \rightarrow J/\psi e^+e^-]=1.06^{+0.16}_{-0.18} \times 10^{-4}$$B[χc0(1P)→J/ψe+e-]=1.06-0.18+0.16×10-4, $$\mathcal {B}[\chi _{c1}(1P) \rightarrow J/\psi e^+e^-]=2.88^{+0.50}_{-0.53} \times 10^{-3}$$B[χc1(1P)→J/ψe+e-]=2.88-0.53+0.50×10-3, and $$\mathcal {B}[\chi _{c2}(1P) \rightarrow J/\psi e^+e^-]=1.74^{+0.22}_{-0.21} \times 10^{-3}$$B[χc2(1P)→J/ψe+e-]=1.74-0.21+0.22×10-3. The calculated branching fractions of $$\chi _{cJ}(1P)\rightarrow J/\psi \mu ^+\mu ^-$$χcJ(1P)→J/ψμ+μ- channels are: $$\mathcal {B}[\chi _{c0}(1P) \rightarrow J/\psi \mu ^+\mu ^-]=3.80^{+0.59}_{-0.64} \times 10^{-6}$$B[χc0(1P)→J/ψμ+μ-]=3.80-0.64+0.59×10-6, $$\mathcal {B}[\chi _{c1}(1P) \rightarrow J/\psi \mu ^+\mu ^-]=2.04^{+0.36}_{-0.38} \times 10^{-4}$$B[χc1(1P)→J/ψμ+μ-]=2.04-0.38+0.36×10-4, and $$\mathcal {B}[\chi _{c2}(1P) \rightarrow J/\psi \mu ^+\mu ^-]=1.66^{+0.19}_{-0.19} \times 10^{-4}$$B[χc2(1P)→J/ψμ+μ-]=1.66-0.19+0.19×10-4.
An estimation for the ascending numbers of knots by Γ-polynomials
Authors: Higa Ryuji 
Published: December 2019

For a knot, the ascending number is the minimum number of crossing changes which are needed to obtain an descending diagram. We study the [Formula: see text]-polynomial of knots with a given ascending number. We give a lower bound of the ascending numbers by using [Formula: see text]-polynomials. We estimate the ascending numbers for 65 prime knots up to 10 crossings by using [Formula: see text]-polynomials, Conway polynomials, and the determinants.
Real-time Traffic Assignment Using Engineered Customizable Contraction Hierarchies
Authors: Buchhold Valentin , Sanders Peter , Wagner Dorothea 
Published: December 2019

Given an urban road network and a set of origin-destination pairs, the traffic assignment problem asks for the traffic flow on each road segment. Common solution algorithms require a large number of shortest-path computations. In this article, we significantly accelerate the computation of flow patterns, enabling interactive transportation and urban planning applications. We achieve this by building a traffic assignment procedure upon customizable contraction hierarchies (CCH), revisiting and carefully engineering CCH customization and queries, and adapting CCH to compute batched point-to-point shortest paths. Although motivated by the traffic assignment problem, our optimizations apply to CCH in general. In contrast to previous work, our evaluation uses real-world production data for all parts of the input. On a metropolitan area encompassing about 2.7 million inhabitants, we decrease the flow-pattern computation for a typical 1-hour morning peak (a quarter million trips) from 90.9 to 14.1 seconds on one core and 2.4 seconds on a 16-core machine. This represents a speedup of 37 over the state of the art and more than three orders of magnitude over the Dijkstra-based baseline.
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer
Authors: Moyer Cassandra L. , Ivanovich Jennifer , Gillespie Jessica L. , Doberstein Rachel , Radke Marc R. , Richardson Marcy E. , Kaufmann Scott H. , Swisher Elizabeth M. , Goodfellow Paul J. 
Published: December 2019

Abstract

Germline loss-of-function mutations in BRCA1 interacting protein C-terminal helicase 1 (BRIP1) are associated with ovarian carcinoma and may also contribute to breast cancer risk, particularly among patients who develop disease at an early age. Normal BRIP1 activity is required for DNA interstrand cross-link (ICL) repair and is thus central to the maintenance of genome stability. Although pathogenic mutations have been identified in BRIP1, genetic testing more often reveals missense variants, for which the impact on molecular function and subsequent roles in cancer risk are uncertain. Next-generation sequencing of germline DNA in 2,160 early-onset breast cancer and 1,199 patients with ovarian cancer revealed nearly 2% of patients carry a very rare missense variant (minor allele frequency &lt; 0.0001) in BRIP1. This is 3-fold higher than the frequency of all rare BRIP1 missense alleles reported in more than 60,000 individuals of the general population (P &lt; 0.0001, χ2 test). Using CRISPR-Cas9 gene editing technology and rescue assays, we functionally characterized 20 of these missense variants, focusing on the altered protein's ability to repair ICL damage. A total of 75% of the characterized variants rendered the protein hypomorph or null. In a clinical cohort of &gt;117,000 patients with breast and ovarian cancer who underwent panel testing, the combined OR associated with BRIP1 hypomorph or null missense carriers compared with the general population was 2.30 (95% confidence interval, 1.60–3.30; P &lt; 0.0001). These findings suggest that novel missense variants within the helicase domain of BRIP1 may confer risk for both breast and ovarian cancer and highlight the importance of functional testing for additional variants.

Significance:
Functional characterization of rare variants of uncertain significance in BRIP1 revealed that 75% demonstrate loss-of-function activity, suggesting rare missense alleles in BRIP1 confer risk for both breast and ovarian cancer.
TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer
Authors: Lehmann Brian D. , Abramson Vandana G. , Sanders Melinda E. , Mayer Erica L. , Haddad Tufia C. , Nanda Rita , Van Poznak Catherine , Storniolo Anna Maria , Nangia Julie R. , Gonzalez-Ericsson Paula I. , Sanchez Violeta , Johnson Kimberly N. , Abramson Richard G. , Chen Sheau-Chiann , Shyr Yu , Arteaga Carlos L. , Wolff Antonio C. , Pietenpol Jennifer A. 
Published: December 2019

AbstractPurpose:Preclinical data demonstrating androgen receptor (AR)–positive (AR+) triple-negative breast cancer (TNBC) cells are sensitive to AR antagonists, and PI3K inhibition catalyzed an investigator-initiated, multi-institutional phase Ib/II study TBCRC032. The trial investigated the safety and efficacy of the AR-antagonist enzalutamide alone or in combination with the PI3K inhibitor taselisib in patients with metastatic AR+ (≥10%) breast cancer.Patients and Methods:Phase Ib patients [estrogen receptor positive (ER+) or TNBC] with AR+ breast cancer received 160 mg enzalutamide in combination with taselisib to determine dose-limiting toxicities and the maximum tolerated dose (MTD). Phase II TNBC patients were randomized to receive either enzalutamide alone or in combination with 4 mg taselisib until disease progression. Primary endpoint was clinical benefit rate (CBR) at 16 weeks.Results:The combination was tolerated, and the MTD was not reached. The adverse events were hyperglycemia and skin rash. Overall, CBR for evaluable patients receiving the combination was 35.7%, and median progression-free survival (PFS) was 3.4 months. Luminal AR (LAR) TNBC subtype patients trended toward better response compared with non-LAR (75.0% vs. 12.5%, P = 0.06), and increased PFS (4.6 vs. 2.0 months, P = 0.082). Genomic analyses revealed subtype-specific treatment response, and novel FGFR2 fusions and AR splice variants.Conclusions:The combination of enzalutamide and taselisib increased CBR in TNBC patients with AR+ tumors. Correlative analyses suggest AR protein expression alone is insufficient for identifying patients with AR-dependent tumors and knowledge of tumor LAR subtype and AR splice variants may identify patients more or less likely to benefit from AR antagonists.
The Effect of Dream Anxiety on Sleep Quality in Inflammatory Bowel Diseases
Authors: Kani Haluk Tarik , Sakalli Kani Ayse , Dural Uzay , Basgoze Emre , Aksu Cagri , Kahraman Merve Meric , Ozen Alahdab Yesim , Atug Ozlen , Kuscu Kemal , Imeryuz Nese 
Published: December 2019

<b><i>Introduction:</i></b> Declining sleep quality is a well-known issue in inflammatory bowel disease (IBD), but dream characteristics of patients with IBD and their role in sleep quality are unknown. In this study, we aimed to examine whether and how patients with ulcerative colitis (UC) and Crohn’s disease (CD) differ on sleep quality, sleepiness level, and dream anxiety (DA) level compared to healthy controls (HC), controlling for their depressive and anxious tendencies. <b><i>Methods:</i></b> Patients and HCs were enrolled prospectively into the study. The Van DA Scale, Pittsburg Sleep Quality Index, Epworth Sleepiness Scale, Beck Depression Index, and State-Trait Anxiety Inventories were used to assess DA, sleep quality, sleepiness, depression, and anxiety, respectively. <b><i>Results:</i></b> Patients with IBD had significantly lower depression (<i>p</i> = 0.004), state anxiety (<i>p</i> = 0.0001), trait anxiety (<i>p</i> = 0.004), and DA (<i>p</i> = 0.0001) than HCs. Although no statistically significant difference in sleep quality was found (<i>p</i> = 0.99), daytime sleepiness was more common in HCs than in IBD patients (<i>p</i> = 0.0001). No statistically significant difference was seen in depression, state anxiety, trait anxiety, DA, sleep quality, and daytime sleepiness between patients with CD and those with UC. No correlation was found between disease activity indices and psychological parameters. <b><i>Conclusion:</i></b> In contrast to previous studies, this study found lower anxiety and depression levels in patients with IBD than in HCs. Moreover, DA score was higher in HCs. For the first time, we revealed that DA may be one of the factors leading to sleep disturbance in patients with IBD.