bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of Colon Cancer Recurrence From Minimal Residual Disease: Computer Optimized Dose Schedules of Intermittent Apoptotic Adjuvant Therapy
Authors: Cockrell Chase , Teague Joseph , Axelrod David E. 
Published: June 2020

PURPOSE Adjuvant chemotherapy is used after surgery for stages II and III colorectal cancer to reduce recurrence. Nevertheless, recurrence may occur years later with the emergence of initially undetected minimal residual disease (MRD). Attempts to reduce recurrence by increasing the dose intensity and increasing the time of adjuvant therapy have been limited by the adverse effects of the recommended cytotoxic agents. The goals of this study were to suggest an alternative to the recommended cytotoxic agents and to determine optimal adjuvant therapy dose schedules that would reduce the percentage of recurrence at 5 years while retaining colon crypt function. METHODS A total of 84,400 dose schedules with different duration, interval between doses, and intensity of treatment were simulated with a high-performance computer. Simulated treatments used the drug sulindac, which had previously been used in primary prevention. With appropriate dose schedules, it can induce apoptosis at the crypt lumen surface while retaining crypt function. We used a computer model of cell dynamics in colon crypts that had been calibrated with measurements of human biopsy specimens. Proliferating mutant cells were assumed to emerge from MRD within crypts. Simulated outcomes included the recurrence percentage at 5 years and the retention of crypt function. RESULTS Optimal dose schedules were determined for adjuvant treatment of MRD that reduced the percentage of recurrence at 5 years of stages I, II, and III colon cancer to zero. CONCLUSION A new adjuvant therapy for colon cancer based upon optimum dose schedules of intermittent apoptotic treatment may prevent the recurrence of colon cancer from MRD and avoid the adverse effects of cytotoxic treatments.
Disparities in Cancer-Specific Survival Between Māori and Non-Māori New Zealanders, 2007-2016
Authors: Gurney Jason , Stanley James , McLeod Melissa , Koea Jonathan , Jackson Chris , Sarfati Diana 
Published: June 2020

PURPOSE While cancer survival is improving across most developed nations, those improvements are not shared equally within their population. Using high-quality national data, we have reviewed the extent to which cancer survival inequities are persisting for indigenous Māori compared with non-Māori New Zealanders and the extent to which these disparities are driven by deprivation, comorbidity, and stage of disease. METHODS Incident cases of cancer (2007-2016) were extracted from the New Zealand Cancer Registry and linked to mortality and hospitalization data. Descriptive, Kaplan-Meier, and Cox regression methods were used to compare survival outcomes between Māori and non-Māori. RESULTS Māori continue to have poorer survival than non-Māori for 23 of the 24 most common causes of Māori cancer death, with the extent of this disparity ranging from 12% to 156%. The magnitude of these disparities varies according to deprivation, comorbidity, and stage. Of note, there was a tendency for survival disparities to be largest among those with no comorbidity. CONCLUSION Māori continue to experience substantial cancer survival inequities. These observations are in keeping with reports from previous decades, which suggest that these disparities persist despite heightened attention. Reduction of the cancer burden on Māori and achievement of equitable survival outcomes require us to prevent cancer for Māori where we can, diagnose Māori patients early when we cannot, and once diagnosed, deliver equitable care to Māori patients at each step along the treatment path.
Exploratory Notes on the Origins of New Fascisms
Authors: Gambetti Zeynep 
Published: June 2020

Abstract
This essay interrogates whether existent analytical tools remain adequate to identify and assess what is perceived as the revival of fascistic tendencies today, ultimately arguing that they are not. Fascism cannot be expected to assume the same forms it did a century ago. Class structures, resource distribution schemes, communication potentials, and modes of belonging and exclusion have undergone significant changes. To determine which of the traits of the contemporary power paradigm would foreground new fascistic tendencies, this essay first revisits some of the most crucial insights in Hannah Arendt's study of the origins of totalitarianism. Arendt's perspective is highly valuable in moving the discussion of fascism beyond the delineation of specific historical events toward a theory of fascist power. The point is to distill from Arendt's insights into the connections among imperialism, fascism, and totalitarianism a number of techniques of government that would enable us to repeat the gesture today, but this time within the biopolitics-security-neoliberalism nexus. The power paradigm that this essay (re)constructs is meant to contribute to identifying fascistic and totalitarian trends irrespective of ideological and historiographic differences.
Translating Solidarity
Authors: Halim Hala 
Published: June 2020

AbstractThis interview with veteran Egyptian translator and interpreter Nehad Salem is preceded by an introduction that situates her biography and formation in relation to the key, interconnected international/internationalist forums in which her career unfolded. A dedicated Third Worldist, Salem participated in crucial events of the liberation period, including the resistance in Port Said during the Suez War, and taught in Algeria in the wake of decolonization. Spotlighting her work in institutions such as the Afro-Asian Peoples’ Solidarity Organization, the Afro-Asian Writers’ Association, and UNESCO, the interview addresses issues of gender and agency in relation to the translator/interpreter, and the poetics and politics of literary translation. The interview traces details about the literary history of the liberation period through Salem's work in the journal Lotus: Afro-Asian Writings, edited by, among others, the Egyptian writer Edwar al-Kharrat, and her translations of the Palestinian poet Mahmoud Darwish and the Egyptian poet Salah Jahin.
Vitamin D for Improved Bone Health and Prevention of Stress Fractures: A Review of the Literature
Authors: Lawley Richard , Syrop Isaac P. , Fredericson Michael 
Published: June 2020

Abstract
Vitamin D is a vital nutrient and hormone needed for many essential functions in overall health. There is growing literature examining the role of vitamin D not only in the general population but also in athletes. The most predominantly studied area of vitamin D pertains to bone health. Recently, there has been increased investigation into the relationship of vitamin D and stress fractures, including genetic polymorphisms, levels of 25-hydroxyvitamin D, and bioavailable vitamin D. This review will address the most recent developments of vitamin D research and its important role in bone health in athletes.
Role of Mechanical Loading for Platelet-Rich Plasma-Treated Achilles Tendinopathy
Authors: Neph Alyssa , Schroeder Allison , Enseki Keelen R. , Everts Peter A. , Wang James H-C. , Onishi Kentaro 
Published: June 2020

Abstract
There is no consensus on the optimal rehabilitation protocol after platelet-rich plasma (PRP) treatment for tendinopathy despite basic science studies showing the critical role of mechanical loading in the restoration of tendon structure and function posttreatment. In this article, we will review tendon mechanobiology, platelet biology, and review levels I and II Achilles tendon clinical studies paying particular attention to the role of mechanical loading in rehabilitation of injured tendons. Animal studies emphasize the synergistic effect of mechanical tendon loading and PRP to treat tendon injury while clinical studies described minimal details on loading protocols.
When Corporate Social Responsibility Backfires: Evidence from a Natural Field Experiment
Authors: List John A. , Momeni Fatemeh 
Published: June 2020

This paper uses a natural field experiment to connect corporate social responsibility (CSR) to an important but often neglected behavior: employee misconduct and shirking. Through employing more than 1,500 workers, we find that our use of CSR increases employee misbehavior—24% more employees act detrimentally toward our firm by shirking on their primary job duties when we introduce CSR. Observed data patterns across the treatments are consonant with a model of “moral licensing,” whereby the “doing good” nature of CSR induces workers to misbehave on another dimension that is harmful to the firm. This paper was accepted by Yan Chen, decision analysis.
Acetabular reaming and sartorius muscle pedicle iliac bone grafting in the treatment of developmental dysplasia of the hip in older children: A retrospective study of 15 patients with more than two years follow-up
Authors: Fan Zhang , Cong Luo , Hang Liu , Ming Li , Jun Wu , Zujie Hu , Haoyu Li 
Published: June 2020

Purpose Despite the early diagnosis and treatment of developmental dysplasia of the hip (DDH), some older children still need open reduction. It is usually difficult to get a satisfactory reduction particularly in patients with acetabular defect. The purpose of this study was to evaluate the short-term outcomes of acetabulum reaming and sartorius muscle pedicle iliac bone grafting in the treatment of older children with DDH and acetabular defect. Methods The records of 15 patients with DDH (mean age 113.9 months (sd 29); 17 hips) who were treated with the reported technique between February 2015 and January 2017 were retrospectively reviewed. All patients acquired regular clinical and radiographic follow-ups, and alterations in the acetabular index, centre-edge angle and acetabular head index were measured. Joint function and radiographic results were evaluated with McKay and Severin modified criteria, respectively. Results A total of 15 patients were followed up for mean 32.4 months (sd 6.9). The percentages of excellent and good conditions were 94.1% (16/17) according to the Severin modified criteria and 88.2% (15/17) according to the McKay modified criteria. Avascular necrosis of the femoral head and redislocation only occurred in one hip. No cases of ankylosis or bone graft absorption occurred during the follow-up. Conclusion Reaming the acetabulum and sartorius muscle pedicle iliac bone grafting for repairing the acetabular defect can recover the arcuate structure by increasing the volume of the acetabulum, which is beneficial for achieving a concentric reduction. The short-term outcome was satisfactory, while the long-term results need to be further observed. Level of Evidence IV – retrospective study
Management of common elective paediatric orthopaedic conditions during the COVID-19 pandemic: The Montreal experience
Authors: Keshet Doron , Bernstein Mitchell , Dahan-Oliel Noemi , Ouellet Jean , Pauyo Thierry , Rabau Oded , Saran Neil , Hamdy Reggie 
Published: June 2020

Purpose To explore safe delays for the treatment of common paediatric orthopaedic conditions when faced with a life-threatening pandemic, COVID-19, and to propose a categorization system to address this question. Methods Review of the literature related to acceptable delays for treatment of common orthopaedic conditions, experience of healthcare professionals from low resource communities and expertise of experienced surgeons. Results Guidelines for the management of cancellations of elective surgeries during a period of resource reallocation are proposed. Elective cases must not be postponed indefinitely as adverse outcomes may result. Triage of waiting lists should include continuous monitoring of the patient and close communication with families despite social distancing and travel restrictions. Telehealth becomes a necessity. Common orthopaedic conditions are triaged into four groups according to urgency and safe and acceptable delay. Categories proposed are Emergent (life and limb threatening conditions), Urgent (within seven days), Semi-elective (postponed for three months) and Elective (postponed for three to 12 months). In total, 25 common orthopaedic conditions are reviewed and categorized. Conclusion Given the uncertainty within healthcare during a pandemic, it is necessary to determine acceptable delays for elective conditions. We report our experience in developing guidelines and propose categorizing elective cases into four categories, based on the length of delay. Telemedicine plays a key role in determining the gravity of each situation and hence the amount of delay. These guidelines will assist others dealing with elective cases in the midst of a crisis. This paper initiates a coordinated effort to develop a consensus statement on safe delays. Published without peer review.
Filterless 16-tupling photonic millimeter-wave generation with Mach–Zehnder modulators using remodulation
Authors: Bashir Dar Aasif , Ahmad Faroze 
Published: June 2020

An optical millimeter-wave generation technique is presented in this paper. The system’s two frequency quadruplers use dual-parallel Mach–Zehnder modulators. A 5 GHz radio frequency signal is fed to a quadrupler, which yields a 20 GHz signal after detection using a photodiode. The detected signal is used for remodulation of the other quadrupler, resulting in an 80 GHz signal with an optical sideband suppression ratio of 28 dB and a radio frequency spurious sideband suppression ratio of 27 dB. Further, the effect on the system performance in terms of the optical sideband suppression ratio and radio frequency spurious sideband suppression ratio with variation of various parameters is also evaluated. The optical sideband suppression ratio is well above 14 dB for a phase offset of

±

9
∘

in phase shifters with a modulation index range of 1.5–3.5 and an amplifier gain range of 25 dB to 32 dB.
Efficient and highly tunable second-harmonic generation in Z-cut periodically poled lithium niobate nanowaveguides
Authors: Chen Jia-Yang , Tang Chao , Ma Zhao-Hui , Li Zhan , Meng Sua Yong , Huang Yu-Ping 
Published: June 2020

Thin-film lithium-niobate-on-insulator (LNOI) has emerged as a superior integrated-photonics platform for linear, nonlinear, and electro-optics. Here we combine quasi-phase-matching, dispersion engineering, and tight mode confinement to realize nonlinear parametric processes with both high efficiency and wide wavelength tunability. On a millimeter-long, Z-cut LNOI waveguide, we demonstrate efficient (

1900
±
500
%

W

−
1

c
m

−
2

) and highly tunable (

−

1.71

n
m

/

K

) second-harmonic generation from 1530 to 1583 nm by type-0 quasi-phase-matching. Our technique is applicable to optical harmonic generation, quantum light sources, frequency conversion, and many other photonic information processes across visible to mid-IR spectral bands.
Broadband chaotic microwave generation through destabilization of period-one nonlinear dynamics in semiconductor lasers for radar applications
Authors: Tseng Chin-Hao , Hwang Sheng-Kwang 
Published: June 2020

This Letter studies a photonic approach for chaotic microwave generation through destabilization of period-one (P1) nonlinear dynamics in a semiconductor laser subject to intensity-modulated (IM) optical injection. Chaos can be excited when the modulation sideband perturbation carried by the IM optical injection is a few gigahertz higher than the lower oscillation sideband of the P1 dynamics. As a result, chaotic microwaves with a spectral distribution of more than 50 GHz and a bandwidth of about 33 GHz are generated without any time-delay signature or modulation-induced peak. Such features provide the generated chaotic microwaves with preferable characteristics for radar applications, including high detection resolution, superior detection unambiguity, strong anti-jamming capability, and simultaneous multi-band detection.
Mode-multiplex plasmonic sensor for multi-analyte detection
Authors: Haider Firoz , Ahmmed Aoni Rifat , Ahmed Rajib , Amouzad Mahdiraji Ghafour , Fahmi Azman Mohd , Adikan Faisal Rafiq Mohamad 
Published: June 2020

Highly sensitive mode-multiplex miniaturized sensors enable the detection and quantification of multiple biomolecules simultaneously through their real-time interactions. Here, we demonstrate a grapefruit photonic crystal fiber (PCF)-based mode-multiplex surface plasmon resonance (SPR) sensor that detects multiple analytes simultaneously. Three grapefruit-shaped air-holes are internally coated with plasmonic gold (Au) material, which allows them to act as mode-multiplex channels that detect three unknown analytes. The sensor performance was investigated using the finite element method (FEM), and the optimized fiber structure was fabricated with the standard stack-and-draw method. For the

y

-polarized mode, channels one and three showed the maximum wavelength sensitivities of 2000 and 18,000 nm/RIU (refractive index unit) at the analyte refractive indices of 1.34 and 1.41, respectively. On the other hand, channel two showed the maximum wavelength sensitivity of 3000 nm/RIU at the analyte refractive index (RI) of 1.36 for the

x

-polarized mode. To the best of our knowledge, this is the first demonstration of a mode-multiplex grapefruit PCF-based SPR sensor to simultaneously detect and quantify three different analytes. We anticipate that the proposed sensor will find potential applications in the detection of real-time biomolecular interactions and binding affinity.
Ultracompact twisted silica taper for 20  kHz to 94  MHz ultrasound sensing
Authors: Fan Huibo , Ma Wenwen , Chen Liang , Bao Xiaoyi 
Published: June 2020

An ultracompact twisted silica taper with an asymmetric structure is fabricated by fire-drawing two twisted single-mode fibers for broadband ultrasound sensing. A piezoelectric transducer (PZT), peaked at 3.7 MHz, is used as an ultrasound generator. A steel plate with a silica taper attached is adhered to the PZT and is used as the ultrasound propagation medium. The transmission spectrum of the silica taper has high contrast owing to multimode interference in this twisted silica structure. Specially, the taper waist length and waist diameter are optimized for the highest optical sensitivity with high contrast at high slope in the transmission spectrum. The ultrasound sensitivity is characterized by a different thickness of the steel plate from 0 to 2.36 mm to achieve the highest ultrasound frequency response. With the taper waist length of 5 mm, waist diameter of 5 µm, and steel thickness of 0 mm, a broadband ultrasound frequency of 20 kHz to 94.4 MHz can be detected at high harmonics of the PZT, verifying the high sensitivity of the compact twisted silica taper.
High-beam-quality 2.1  µm pumped mid-infrared type-II phase-matching BaGa4Se7 optical parametric oscillator with a ZnGeP2 amplifier
Authors: Liu Gaoyou , Chen Yi , Li Zhuang , Yang Ke , Yao Baoquan , Yao Jiyong , Wang Ruixue , Yang Chao , Mi Shuyi , Dai Tongyu , Duan Xiaoming 
Published: June 2020

We firstly demonstrated a tunable 2.1 µm pumped mid-infrared type-II phase-matching

B
a
G
a

4

S
e

7

(BGSe) optical parametric oscillator (OPO). A signal tuning range of 3.82–3.99 µm was achieved. With a signal light produced by the BGSe OPO serving as seed, the

Z
n
G
e
P

2

(ZGP) optical parametric amplifier (OPA) was first introduced. A 4.35 W mid-infrared laser was obtained in the novel type-II BGSe OPO with a ZGP OPA system, which was pumped by a 24 W 1 kHz

Q

-switched Ho:YAG laser. The beam quality factor

M
2

of the whole system is

∼

2.3

, which is over a 50% promotion on the previous

M
2

results of single BGSe OPO.
Evaluating E-Procurement Impact In The Public Sector
Authors: Boafo Nana Danso , Ahudey Eric 
Published: June 2020

Despite the several benefits gained as a result of e-procurement, the actual potential of it in the public sector in Ghana has not been realized. Studies has further suggested that little is known of e-procurement in most organizations. This demonstrates that the area is under-researched and hence, there is a gap that needs to be filled in literature on the aspect of e-procurement and its impacts in the public sector in Ghana. Therefore the study was to assess the impact of e-procurement in the Ghanaian public sector. The research design was descriptive. Both primary and secondary data was used. Purposive sample method was used to select 15 public sector organisations in Ghana for the study. Multiple linear regression was used to analyze the data. Findings revealed that, e-procurement leads to an effective E-tender evaluation (ETE), improves transparency in supply selection, improve procurement record management and effective supply relationships can be made easy. Based on the finding the study recommended that, Developing countries governments must invest heavily in e-procurement infrastructure to enable its usage in all sectors. And also procurement officers must also be trained well to enable its usage. And lastly e- procurement should be mandatory in all public sector procurements in the country.
Development of Post-Pandemic Covid19 Higher Education Resilience Framework in Malaysia
Authors: ABDULLAH MOKHTAR , Husin Nor Azilah , Haider Ameer 
Published: June 2020

The pandemic of Covid-19 will drastically change the world. The thought and functioning of governments, organisations, and citizens will change dramatically – even for the long term. The higher education (HE) market is currently experiencing a tectonic change among many economic sectors. Following the pandemic in Covid-19, the country is home to tens of thousands of students either forced to live in the campus or deportation from the campuses and academic staff. Higher education institutions (HEI) are split up and teachers and students struggle with the new sudden law of teaching and learning completely implemented in the field of technology. How has Covid 19 pandemic altered main processes in education, including academic recruitment, academic management, teaching and learning processes, study and advancement processes, student life (accommodations on the campus, financial and co-curricular activities and other student welfare activities including food, transportation etc.)? On the other hand, how has Covid-19 compelled the institutions of HE to implement new approaches, and to let go of their current teaching practices. The benefits, drawbacks and barriers to online platforms are included. In addition, intellectual honesty is a crucial concern in the online educational network. In this paper, all the main issues described above will be addressed through the development of a conceptual framework as a response to the Covid-19 pandemic that is happening throughout the world. The framework is based on the propositions developed by Duchek (2020). In this process-based framework the issues are connected to a set of constructs that act as enablers of Higher Education Resilience (HER). The enablers or drivers of HER include ‘meta-capability’ of HE (knowledge, resource availability, social resources, and power/responsibility) and resilience stages (anticipation, coping, and adaptation). The practical application of this study is the formulation of Higher Education Resilience Index (HERI) which will help stakeholders such Ministry of Higher Education (MOHE) to categorize each HEI according to the level of HERI, as either Very Low, Low, Moderate, and High Resilience. Using the HERI categories the governments, MOHE in particular, would be able to come up with ‘stimulus packages’ for HEIs that needs assistance (financial and non-financial) from the government.