bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-body voxel-based internal dosimetry using deep learning
Authors: Akhavanallaf Azadeh , Shiri Iscaac , Arabi Hossein , Zaidi Habib 
Published: September 2020

Abstract
Purpose
In the era of precision medicine, patient-specific dose calculation using Monte Carlo (MC) simulations is deemed the gold standard technique for risk-benefit analysis of radiation hazards and correlation with patient outcome. Hence, we propose a novel method to perform whole-body personalized organ-level dosimetry taking into account the heterogeneity of activity distribution, non-uniformity of surrounding medium, and patient-specific anatomy using deep learning algorithms.

Methods
We extended the voxel-scale MIRD approach from single S-value kernel to specific S-value kernels corresponding to patient-specific anatomy to construct 3D dose maps using hybrid emission/transmission image sets. In this context, we employed a Deep Neural Network (DNN) to predict the distribution of deposited energy, representing specific S-values, from a single source in the center of a 3D kernel composed of human body geometry. The training dataset consists of density maps obtained from CT images and the reference voxelwise S-values generated using Monte Carlo simulations. Accordingly, specific S-value kernels are inferred from the trained model and whole-body dose maps constructed in a manner analogous to the voxel-based MIRD formalism, i.e., convolving specific voxel S-values with the activity map. The dose map predicted using the DNN was compared with the reference generated using MC simulations and two MIRD-based methods, including Single and Multiple S-Values (SSV and MSV) and Olinda/EXM software package.

Results
The predicted specific voxel S-value kernels exhibited good agreement with the MC-based kernels serving as reference with a mean relative absolute error (MRAE) of 4.5 ± 1.8 (%). Bland and Altman analysis showed the lowest dose bias (2.6%) and smallest variance (CI: − 6.6, + 1.3) for DNN. The MRAE of estimated absorbed dose between DNN, MSV, and SSV with respect to the MC simulation reference were 2.6%, 3%, and 49%, respectively. In organ-level dosimetry, the MRAE between the proposed method and MSV, SSV, and Olinda/EXM were 5.1%, 21.8%, and 23.5%, respectively.

Conclusion
The proposed DNN-based WB internal dosimetry exhibited comparable performance to the direct Monte Carlo approach while overcoming the limitations of conventional dosimetry techniques in nuclear medicine.
Mixing characterization in different helically coiled configurations by laser-induced fluorescence
Authors: Kováts P. , Velten C. , Mansour M. , Thévenin D. , Zähringer K. 
Published: September 2020

AbstractFlow Mixing of two miscible liquids has been characterized experimentally in three different helically coiled reactor configurations of two different lengths in the laminar flow regime at Re = 50…1000. A straight helical coil, a coiled flow inverter, and a new coiled flow reverser have been built, each in a 3-turn and a 6-turn configuration. Laser-induced fluorescence of resorufin has been used to visualize and quantify mixing in cross-sections throughout the reactors. A mixing coefficient is derived from the fluorescence images to allow for a quantitative measure and comparison of the six configurations. It becomes obvious from these experimental results, that an early flow redirection in the helical configuration is beneficial to mixing. The 3-turn reactors achieve nearly the same mixing coefficients as the 6-turn reactors with the double length. This can be explained by the stabilizing effect of the Dean vortices in the helix, which develop during the first two turns. After that, the liquid is trapped inside the vortices and further mixing is inhibited. Accordingly, the coiled flow inverter and coiled flow reverser configurations lead to much higher mixing coefficients than the straight helical coil. The results of these measurements are now used for validation of numerical simulations, which reproduce the geometrical and flow conditions of the experiments. Some exemplary results of these calculations are also shown in this article.
Graphic abstract

Mass fractions of tracer fluid at Re = 500 in the six examined helix configurations.
Competitive balance when winning breeds winners
Authors: Clark Derek J. , Nilssen Tore 
Published: September 2020

AbstractIn contest settings, heterogeneity between contestants generally leads to low effort provision, and many instruments have been suggested to restore competitive balance. We suggest that heterogeneity may evolve depending upon the outcome of previous contests. Restoring competitive balance in this setting is challenging, and we consider the choice faced by a principal who can distribute a prize fund over two consecutive all-pay auction contests. Contestants are heterogeneous in the sense that one of them has a head start in the first contest. The winner of contest one gains the stage prize and a net head start in contest two; the size of this net head start also varies between players. The head start of the early leader can be increased, neutralized or overturned. The principal aims to maximize total effort. We show how the potential head start that the initial underdog can gain is critical in determining expected efforts. When this parameter is small, the principal can do no better than running a single contest. When the initial underdog can catch up and surpass the first-contest favourite, there is scope to do better. Indeed, it is possible to completely neutralize the initial heterogeneity and capture all of the surplus from the players, inciting a level of expected effort equal to the prize value. Competitive balance is achieved by a judicious division of the prize budget.
Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body
Authors: Alfaar Ahmad Samir , Saad Anas M. , KhalafAllah Mahmoud Tawfik , Elsherif Omneya Ezzat , Osman Moataz Hamed , Strauß Olaf 
Published: September 2020

Abstract
Purpose
The eye and its adnexal structures can give rise to first or consecutive primary malignancies or to encounter metastasis. Our aim was to define the characteristics of the second primary neoplasms affecting the eye and its adnexa and find the risk modifying factors for them after malignancies elsewhere in the body.

Methods
We have queried the Surveillance, Epidemiology and End-Results “SEER”-9 program of the National Cancer Institute for the malignancies of the eye and its adnexa that occurred between 1973 and 2015. The malignancies were ordered chronologically according to their incidence: first or second primary malignancies. The tumors were classified according to ICD-O-3 classification. Standardized incidence ratios (SIR) and survival probabilities were calculated for subgroups.

Results
Among 3,578,950 cancer patients, 1203 experienced a second malignancies of the eye and its adnexa. The first malignancy was diagnosed between 50 and 69 years of age in 58.94% of them. The eyelid showed 280 events, while 50 in lacrimal gland, 181 in the orbit, 21 in the overlapping lesions, 15 in optic nerve, 148 in the conjunctiva, 9 in the cornea, 6 in the Retina, 379 in the choroid, and 93 in the ciliary body. The SIR of a second malignancy after a prior non-Hodgkin lymphoma was 2.42, and in case of previous skin carcinomas it was 3.02, melanoma of skin, and 2.13 and 1.58 in oral cavity/pharynx malignancies. The second ocular and adnexal neoplasms increased steadily over the 5-year periods on contrary to first primary neoplasms. The survival of patients affected with first ocular and adnexal neoplasms was significantly higher than those with second ocular and adnexal neoplasms. On the other side, second primary ocular and adnexal tumors showed a better survival than second primary malignancies elsewhere.

Conclusions
The epidemiological differences between first and second ocular and adnexal primaries suggest different underlying mechanisms. Careful ocular examination should be integrated in the long-term follow-up plan of cancer patients. Special attention should be given to patients with non-Hodgkin’s lymphoma and melanoma as first primary.
Increasing trend in Japan Sea Throughflow transport
Authors: Kida Shinichiro , Takayama Katsumi , Sasaki Yoshi N. , Matsuura Hiromi , Hirose Naoki 
Published: September 2020

AbstractA long-term increasing trend in the transport of the Japan Sea Throughflow is observed from sea-level differences across the Tsushima Strait. Tidal gauge observations show sea level at Hakata, Japan, increasing at a higher rate than that at Busan, Korea. Numerical modeling results suggest that this increasing trend is forced by a northward shift in the Kuroshio axis. As the Kuroshio axis moves northward, sea level along the southern coast of Japan increases. The signal then propagates anticyclonically along the coast as topographic Rossby waves and Kelvin waves, raising sea level and, thus, increasing transport through the Tsushima Strait.
Exploring Personalised Autonomous Vehicles to Influence User Trust
Authors: Sun Xu , Li Jingpeng , Tang Pinyan , Zhou Siyuan , Peng Xiangjun , Li Hao Nan , Wang Qingfeng 
Published: September 2020

AbstractTrust is a major determinant of acceptance of an autonomous vehicle (AV), and a lack of appropriate trust could prevent drivers and society in general from taking advantage of such technology. This paper makes a new attempt to explore the effects of personalised AVs as a novel approach to the cognitive underpinnings of drivers’ trust in AVs. The personalised AV system is able to identify the driving behaviours of users and thus adapt the driving style of the AV accordingly. A prototype of a personalised AV was designed and evaluated in a lab-based experimental study of 36 human drivers, which investigated the impact of the personalised AV on user trust when compared with manual human driving and non-personalised AVs. The findings show that a personalised AV appears to be significantly more reliable through accepting and understanding each driver’s behaviour, which could thereby increase a user’s willingness to trust the system. Furthermore, a personalised AV brings a sense of familiarity by making the system more recognisable and easier for users to estimate the quality of the automated system. Personalisation parameters were also explored and discussed to support the design of AV systems to be more socially acceptable and trustworthy.
Agile methodology of well pad development
Authors: Abramov Aleksandr 
Published: September 2020

AbstractPlacing of wells in clusters with unequal number of thereof is an emerging concept of well pad development which still requires scrutiny even from a theoretical standpoint. The concept has its potential in improving economic efficiency of one of the most capital intensive processes in upstream sector of petroleum industry—the well pad drilling. To advocate and strengthen this profitability enhancing potential, this work integrates clustering of unequal number of wells into modern project management methodologies (agile project management), which has not been done before. It is shown that such symbiosis, which is called here the adaptive well pad development (or agile methodology of well pad development), has twofold benefit consisting of (1) managing of and accounting for uncertainties of real projects and (2) further improving economic performance of development projects in comparison with standalone well pad configurations with unequal number of wells. To exemplify these advantages, detailed simulations of well pad drilling projects were performed with equal and unequal number of wells in clusters. The simulation model accounting for more than 40 parameters and individual features of wells shows that combination of unequal well clustering configurations with adaptation of well pad designs to updates in project parameters results in significant improvements to the net present value (NPV). For three drilling scenarios studied in this work, the NPV increments ranged from 8 to 36%. Additionally, it was found that groupings with unequal number of wells consistently outperform groupings with equal number of wells in uncertain conditions, and NPV improvements from 10 to 20% have been obtained. These findings enrich understanding of the vast space of clustering schemes with unequal number of wells and demonstrate how these well pad configurations can be applied to use ever-changing environment to one's advantage. On basis of this computational study, it is now valid to assert with high degree of certainty and confidence that industrial deployment of clustering with unequal number of wells in combination with proper organizational measures results in boost to the NPV of well pad development projects at the level of several to tens of percent.
Healthcare Students on Placements: a Cyclical Quality Method for Satisfaction Assessments
Authors: Boutillier Camille , Jeanrenaud Luc , Gilles Jean-Luc , Bouche Laurence , Cotting Jocelyne Quillet 
Published: September 2020

AbstractThe Lausanne University Hospital (CHUV, Switzerland) is a university hospital with more than 11,000 employees who perform clinical, research and teaching roles. It was ranked in March 2019 among the ten best hospitals in the world according to the magazine Newsweek. The education scheme of the CHUV includes the practical training of more than 1700 young people, in particular from the University of Applied Sciences and Arts of Western Switzerland (HES-SO). This research and development, carried out in collaboration with the University of Teacher Education of State of Vaud (UTE Vaud), has enabled the creation and implementation of a cyclical method for evaluating the satisfaction of HES-SO healthcare students at CHUV. The method created and tested—the Cycle of Construction and Quality Control for Satisfaction Evaluations (CCQCSE)—comprises nine stages: Issues, Analysis, Design, Items, Information, Collection, Processing, Feedback and Adjustment. It was designed with the help of a multidisciplinary team of healthcare professionals (CHUV) and experts in education sciences (UTE Vaud) as part of a master’s thesis (Kaeser 2018) directed by our research team. A 4-month pilot phase allowed more than 250 placement students’ satisfaction levels to be collected with respect to ten aspects of the practical training scheme, and provided diagnostic feedback. Identifying strengths and areas for improvement has significantly helped with the development of a quality policy for student training at the institution. CCQCSE is now considered as a robust method in line with the quality measures already in place at CHUV. In particular, it encouraged those responsible for the practical training to reflect on their mentoring practices. Beyond the context of CHUV and the mentoring of healthcare students on placements, the CCQCSE model could be transferred to other sectors in which training placements are offered, opening up new avenues of collaborative research.
The 1994 Piedmont flood: an archetype of extreme precipitation events in Northern Italy
Authors: Grazzini F. , Fragkoulidis G. , Pavan V. , Antolini G. 
Published: September 2020

AbstractExtreme precipitation events (EPEs) are meteorological phenomena of major concern for the densely populated regions of northern and central Italy. Although statistically rare, they tend to be recurrent in autumn and share common characteristics in the large-scale dynamical evolution responsible for their generation. Past studies on EPEs have reported, as the main triggering factor, a meridionally elongated upper-level trough embedded in an incoming Rossby wave packet. In this respect, we show how the meteorological conditions leading to the devastating 1994 Piedmont flood represent a typical flow evolution for this type of extreme events. Exploiting the systematic classification of EPEs recently published by the authors and taking advantage of a new observational dataset, this article revisits the role of the large-scale flow on this and similar cases of past EPEs.
Toward a standardized procedure for charcoal analysis
Authors: Tsakiridou Margarita , Cunningham Laura , Hardiman Mark 
Published: September 2020

AbstractSedimentary charcoal records are used for understanding fire as an earth system process; however, no standardized laboratory methodology exists. Varying sample volumes and chemical treatments (i.e., type of chemical for length of time) are used for the deflocculation and extraction of charcoal from sediment samples. Here, we present the first systematic assessment of the effect of commonly used chemicals on charcoal area and number of fragments. In modern charcoal the area of fragments was significantly different depending on the chemical treatment. We subsequently applied H2O2 (33%), NaClO (12.5%), and HNO3 (50%) to a late-glacial–early Holocene paleorecord and tested different sample volumes. The effects of the treatments were consistent between modern and fossil experiments, which demonstrates the validity of applying results from the modern experiment to the fossil records. Based on our experiments we suggest (1) H2O2 33%, especially for highly organic sediments; (2) avoidance of high concentrations of NaClO for prolonged periods of time, and of HNO3; and (3) samples of 1 cm3 provided typically consistent profiles. Our results indicate that charcoal properties can be influenced by treatment type and sample volume, thus emphasizing the need for a common protocol to enable reliable multi-study comparisons or composite fire histories.
Optimizing extraction and targeted capture of ancient environmental DNA for reconstructing past environments using the PalaeoChip Arctic-1.0 bait-set
Authors: Murchie Tyler J. , Kuch Melanie , Duggan Ana T. , Ledger Marissa L. , Roche Kévin , Klunk Jennifer , Karpinski Emil , Hackenberger Dirk , Sadoway Tara , MacPhee Ross , Froese Duane , Poinar Hendrik 
Published: September 2020

AbstractSedimentary ancient DNA (sedaDNA) has been established as a viable biomolecular proxy for tracking taxon presence through time in a local environment, even in the total absence of surviving tissues. SedaDNA is thought to survive through mineral binding, facilitating long-term biomolecular preservation, but also challenging DNA isolation. Two common limitations in sedaDNA extraction are the carryover of other substances that inhibit enzymatic reactions, and the loss of authentic sedaDNA when attempting to reduce inhibitor co-elution. Here, we present a sedaDNA extraction procedure paired with targeted enrichment intended to maximize DNA recovery. Our procedure exhibits a 7.7–19.3x increase in on-target plant and animal sedaDNA compared to a commercial soil extraction kit, and a 1.2–59.9x increase compared to a metabarcoding approach. To illustrate the effectiveness of our cold spin extraction and PalaeoChip capture enrichment approach, we present results for the diachronic presence of plants and animals from Yukon permafrost samples dating to the Pleistocene-Holocene transition, and discuss new potential evidence for the late survival (~9700 years ago) of mammoth (Mammuthus sp.) and horse (Equus sp.) in the Klondike region of Yukon, Canada. This enrichment approach translates to a more taxonomically diverse dataset and improved on-target sequencing.
PEOPLING OF OCEANIA: CLARIFYING AN INITIAL SETTLEMENT HORIZON IN THE MARIANA ISLANDS AT 1500 BC
Authors: Carson Mike T 
Published: September 2020

ABSTRACTRadiocarbon (14C) has been instrumental in clarifying how people came to inhabit the expanse of Pacific Oceania, now supporting an “incremental growth model” that shows a number of long-distance sea-crossing migrations over the last few millennia. A crucial step in this narrative involved the initial settlement of the remote-distance Oceanic region, in the case of the Mariana Islands around 1500 BC. The Marianas case can be demonstrated through delineation of stratigraphic layers, dating of individual points or features within those layers, redundant dating of samples in secure contexts, localized and taxon-specific corrections for marine samples, and cross-constraining dating of superimposed layer sequences. Based on the technical and methodological lessons from the Marianas example, the further steps of the incremental growth model will continue to be refined across Pacific Oceania. Many of these issues may be relevant for broader research of ancient settlement horizons in other regions.
Cytogenomic results following high-chance non-invasive prenatal testing: a UK national audit
Authors: Togneri Fiona S. , Allen Stephanie K. , Mann Kathy , Holgado Elaine , Morgan Sian 
Published: September 2020

Abstract

Objective
Non-invasive prenatal testing (NIPT) is increasingly being adopted as a screening test in the UK and is currently accessed through certain National Health Service healthcare systems or by private provision. This audit aims to describe reasons for and results of cytogenomic investigations carried out within UK genetic laboratories following an NIPT result indicating increased chance of cytogenomic abnormality (‘high-chance NIPT result’).

Method
A questionnaire was sent out to 24 genetics laboratories in the UK and completed by 18/24 (75%).

Results
Data were returned representing 1831 singleton pregnancies. A total of 1329 (73%) invasive samples were taken following NIPT results showing a high chance of trisomy 21; this was confirmed in 1305 (98%) of these by invasive sampling. Trisomy 21 was confirmed in >99% of patients who also had high-screen risk results or abnormal scan findings. Amongst invasive samples taken due to NIPT results indicating a high chance of trisomy 18, 84% yielded a compatible result, and this number dropped to 49% for trisomy 13 and 51% for sex chromosomes.

Conclusion
In the UK, the majority of patients having invasive sampling for high-chance NIPT results are doing so following an NIPT result indicating an increased chance of common trisomies (92%). In this population, NIPT performs particularly well for trisomy 21, but less well for other indications.
ARE YOU SERIOUS? ANALYSING EXAGGERATION IN RICHARD AYRES'SNO. 37B
Authors: Coenen-Rowe Lewis 
Published: September 2020

ABSTRACTExaggeration as a deliberate aesthetic device has seen increased popularity with composers working in the western art music tradition in the last few decades. Their music promotes a feeling of excessiveness as an intentional compositional effect, worthy of being taken seriously. This would seem to encourage the development of analytical techniques for understanding how it works, but almost by definition exaggeration tends to be resistant to analysis, its transgressive, anti-rational character appearing incompatible with the systematic approaches associated with this discipline. This article analyses the forms of exaggeration employed in Richard Ayres's orchestral pieceNo. 37b(2006) and the techniques used to achieve them, developing a framework for how we might attempt to analyse exaggeration in a manner that is rigorous but sensitive to the nature of musical exaggeration. The article finishes by making the case for how exaggeration can be interpreted as sincere as well as ironic and why deliberate exaggeration has become an appropriate and attractive device for composers in the last few decades