bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polynomial Silent Self-Stabilizing p-Star Decomposition†
Authors: Haddad Mohammed , Johnen Colette , Köhler Sven 
Published: November 2019

Abstract
We present a silent self-stabilizing distributed algorithm computing a maximal $\ p$-star decomposition of the underlying communication network. Under the unfair distributed scheduler, the most general scheduler model, the algorithm converges in at most $12\Delta m + \mathcal{O}(m+n)$ moves, where $m$ is the number of edges, $n$ is the number of nodes and $\Delta $ is the maximum node degree. Regarding the time complexity, we obtain the following results: our algorithm outperforms the previously known best algorithm by a factor of $\Delta $ with respect to the move complexity. While the round complexity for the previous algorithm was unknown, we show a $5\big \lfloor \frac{n}{p+1} \big \rfloor +5$ bound for our algorithm.
Fish from a polluted lake (Lake Chivero, Zimbabwe): a food safety issue of concern
Authors: Manjengwa Francis , Nhiwatiwa Tamuka , Nyakudya Elijah , Banda Petronella 
Published: November 2019

Abstract

Objectives
A study to determine food safety hazard status of fish products from Lake Chivero was conducted in selected high density suburbs of Harare. Lake water and fish were tested for E. coli O157:H7, total bacterial, fungal counts, mercury (Hg) and aflatoxin B1 (AFB1) to determine contamination levels and assessing human health hazard exposure.

Materials and Methods
Membrane filtration method was used to determine E. coli O157:H7 viable counts using CHROM agar. Plate count and Potato dextrose agar were used for determination of total viable bacterial and fungal counts. Concentrations of Hg and AFB1 in fish and water were determined by Atomic Absorption Spectrophotometer and High Performance Liquid Chromatography-Mass Spectrometry. A questionnaire survey was conducted on 136 adult fish consumers to determine the fish consumption patterns to assess hazard exposure against international standards.

Results
Significant levels of microbial contamination above international standards in both fish and water were recorded. Mean E. coli O157:H7 counts were 106 ± 10 (cfu/cm2) in fish and 52 ± 14 (cfu/100ml) in water. Mean Log10 TBC were 8.98 ± 0.26 (cfu/cm2) in fish and 9.05 ± 0.05 (cfu/ml) in water. Mean Log10 TFC were 4.83 ± 0.02 (cfu/cm2) in fish and 4.56 ± 0.03 (cfu/ml) in water. Hg and AFB1 were 0.018 (µg/kg) and 0.025 (µg/kg) in fish and 0.008 (µg/kg) and 0.005 (µg/kg) in water, both with a hazard quotient (HQ) <1 using CODEX STAN 193-1995 of 2015.

Conclusion
Fish and water are contaminated with E. coli O157:H7, contain bacterial and fungal loads above international food safety guidance levels. Fish were caught already contaminated with pathogens together with toxigenic Hg and carcinogenic AFB1 although their concentration levels are within international food safety toxicological levels. Levels of Hg and AFB1 in water were almost double that of fish, implying bio-accumulation occurred in fish. Thus, fish consumers are exposed to food safety hazards and are at risk of contracting foodborne illnesses from consuming contaminated fish.
The impact of the obstetrical risk insurance scheme in Mauritania on maternal healthcare utilization: a propensity score matching analysis
Authors: Ravit Marion , Ravalihasy Andrainolo , Audibert Martine , Ridde Valéry , Bonnet Emmanuel , Raffalli Bertille , Roy Flore-Apolline , N’Landu Anais , Dumont Alexandre 
Published: November 2019

Abstract
In Mauritania, obstetrical risk insurance (ORI) has been progressively implemented at the health district level since 2002 and was available in 25% of public healthcare facilities in 2015. The ORI scheme is based on pre-payment scheme principles and focuses on increasing the quality of and access to both maternal and perinatal healthcare. Compared with many community-based health insurance schemes, the ORI scheme is original because it is not based on risk pooling. For a pre-payment of 16–18 USD, women are covered during their pregnancy for antenatal care, skilled delivery, emergency obstetrical care [including caesarean section (C-section) and transfer] and a postnatal visit. The objective of this study is to evaluate the impact of ORI enrolment on maternal and child health services using data from the Multiple Indicator Cluster Survey (MICS) conducted in 2015. A total of 4172 women who delivered within the last 2 years before the interview were analysed. The effect of ORI enrolment on the outcomes was estimated using a propensity score matching estimation method. Fifty-eight per cent of the studied women were aware of ORI, and among these women, more than two-thirds were enrolled. ORI had a beneficial effect among the enrolled women by increasing the probability of having at least one prenatal visit by 13%, the probability of having four or more visits by 11% and the probability of giving birth at a healthcare facility by 15%. However, we found no effect on postnatal care (PNC), C-section rates or neonatal mortality. This study provides evidence that a voluntary pre-payment scheme focusing on pregnant women improves healthcare services utilization during pregnancy and delivery. However, no effect was found on PNC or neonatal mortality. Some efforts should be exerted to improve communication and accessibility to ORI.
Estimating stock status from relative abundance and resilience
Authors: Froese Rainer , Winker Henning , Coro Gianpaolo , Demirel Nazli , Tsikliras Athanassios C , Dimarchopoulou Donna , Scarcella Giuseppe , Palomares Maria Lourdes Deng , Dureuil Manuel , Pauly Daniel 
Published: November 2019

AbstractThe Law of the Sea and regional and national laws and agreements require exploited populations or stocks to be managed so that they can produce maximum sustainable yields. However, exploitation level and stock status are unknown for most stocks because the data required for full stock assessments are missing. This study presents a new method [abundance maximum sustainable yields (AMSY)] that estimates relative population size when no catch data are available using time series of catch-per-unit-effort or other relative abundance indices as the main input. AMSY predictions for relative stock size were not significantly different from the “true” values when compared with simulated data. Also, they were not significantly different from relative stock size estimated by data-rich models in 88% of the comparisons within 140 real stocks. Application of AMSY to 38 data-poor stocks showed the suitability of the method and led to the first assessments for 23 species. Given the lack of catch data as input, AMSY estimates of exploitation come with wide margins of uncertainty, which may not be suitable for management. However, AMSY seems to be well suited for estimating productivity as well as relative stock size and may, therefore, aid in the management of data-poor stocks.
Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients
Authors: Douglas Cameron M , Barnard Richard , Holder Daniel , Leavitt Randi , Levitan Diane , Maguire Maureen , Nickle David , Teal Valerie , Wan Hong , van Alewijk Dirk C J G , van Doorn Leen-Jan , Chou Sunwen , Strizki Julie 
Published: November 2019

AbstractBackgroundLetermovir (LET), a cytomegalovirus (CMV) deoxyribonucleic acid (DNA) terminase inhibitor, was recently approved for prophylaxis of CMV infection in adult CMV-seropositive recipients of allogeneic hematopoietic stem cell transplantation. Cytomegalovirus genotyping was performed to identify LET-resistance-associated variants (RAVs) among subjects in a Phase 3 trial.MethodsThe CMV UL56 and UL89 genes, encoding subunits of CMV DNA terminase, were sequenced from plasma collected from subjects with clinically significant CMV infection (CS-CMVi). Novel variants were evaluated by recombinant phenotyping to assess their potential to confer resistance to LET.ResultsGenotyping was successful for 50 of 79 LET subjects with CS-CMVi. Resistance-associated variants (encoding pUL56 V236M and C325W) were detected independently in subjects 1 and 3 who experienced CS-CMVi while receiving LET prophylaxis, and 2 other variants (encoding pUL56 E237G and R369T) were detected &gt;3 weeks after subjects 2 and 3, respectively, had discontinued LET prophylaxis and received preemptive therapy with ganciclovir.ConclusionsThe detected incidence of CMV resistance among subjects who received LET as prophylaxis in this Phase 3 trial was low. The LET RAVs that were detected mapped to the CMV UL56 gene at positions associated with reduced susceptibility to LET based on resistance selections in cell culture.
The Effects of Japanese Encephalitis Vaccine and Accelerated Dosing Scheduling on the Immunogenicity of the Chimeric Yellow Fever Derived Tetravalent Dengue Vaccine: A Phase II, Randomized, Open-Label, Single-Center Trial in Adults Aged 18 to 45 Years in the United States
Authors: Glass Aaron , Polhemus Mark , Wang Dongliang , Jarman Richard G , Thomas Stephen J , Friberg Heather , Currier Jeffrey R , Bonaparte Matthew , De La Barra Rafael , Princiotta Michael F , Abbott Mark , Cuzzo Brian , Machabert Tifany , Sridhar Saranya , Endy Timothy P 
Published: November 2019

Abstract

Background
Dengue is a global health problem requiring an effective, safe dengue vaccine.

Methods
We report the results of a phase II, randomized, open-label, single-center trial in adults aged 18 to 45 years in the United States designed to explore the effects of the Chimeric Yellow Fever Derived Tetravalent Dengue Vaccine (CYD-TDV, Dengvaxia) when administered on its designated schedule (months 0, 6, and 12) or on an accelerated dosing schedule (months 0, 2, and 6) and/or given before, or concomitantly with, a vaccine against Japanese encephalitis (JE).

Results
Based on dengue virus serotype-specific neutralizing antibody (NAb), the accelerated dosing schedule was comparable to the 0, 6, and 12-month schedule. Giving JE vaccine concurrently with CYD-TDV did not result in an increase in overall NAb titers. Immunophenotyping of peripheral blood mononuclear cells revealed an increase in activated CD8+ T cells after CYD-TDV vaccination, a phenomenon that was greatest for the JE vaccine primed.

Conclusions
We conclude that an accelerated dosing schedule of CYD-TDV results in essentially equivalent dengue serotype-specific NAb titers as the currently used schedule, and there may be an early benefit in antibody titers and activated CD8+ T cells by the administration of the JE vaccine before CYD-TDV vaccination.
Predictive value of cadherin-11 for subsequent recurrence and progression in non-muscle invasive bladder cancer
Authors: Chen Ming-kun , Chen Zi-jian , Xiao Kang-hua , Qin Zi-ke , Ye Yun-lin , Wen Wei-jie , Bian Jun , Xue Kang-yi , Zhou Qi-zhao , Guo Wen-bing , Zhou Jun-hao , Xia Ming , Li Xin , Liu Cun-dong 
Published: November 2019

AbstractBackgroundCadherin-11 (CDH11) is a type II cadherin and reported to function as an oncogene in various cancers. Our present study aims to investigate the role of CDH11 in bladder cancer (BCA).MethodsBioinformatics analysis was performed in four independent microarray data including 56 non-muscle-invasive bladder cancer (NMIBC) and 132 muscle-invasive bladder cancer (MIBC) tissues from Gene Expression Omnibus to screen out differentially expressed genes. Next, we detected CDH11 expression in BCA specimens and cell lines by qPCR and western blotting assays. Immunohistochemical analyses were performed in 209 paraffin-embedded BCA samples and 30 adjacent normal bladder tissues.ResultsBioinformatics analysis revealed that CDH11 had a higher expression level in MIBC tissues than in NMIBC, which was consistent with our clinical BCA specimens and cell lines at both mRNA and protein levels. Immunohistochemical analysis demonstrated that over-expression of CDH11 was closely related to the histological grade, pT status, tumour size and poor outcomes of BCA patients. What’s more, CDH11 (area under curve (AUC) = 0.673 and 0.735) had a better predictive value than E-cadherin (AUC = 0.629 and 0.629) and a similar discrimination with the European Organization for Research and Treatment of Cancer (EORTC) score system (AUC = 0.719 and 0.667) in evaluating potential recurrence and progression of NMIBC. Moreover, combination of CDH11 and EORTC score system was the best predictive model in predicting recurrence of NMIBC (AUC = 0.779) among the three models.ConclusionsCDH11 was a reliable therapeutic target in BCA and a useful index to predict the possibilities of recurrence and progression in NMIBC patients.
Prosocial Behaviors: A Matter of Altruism or Public Service Motivation?
Authors: Piatak Jaclyn S , Holt Stephen B 
Published: November 2019

AbstractIn recent years, public service motivation (PSM) research has grown substantially, but is still largely limited to the field of public administration. To be able to export the theory and measures of PSM to other disciplines, we need more conceptual clarity. Some suggest PSM is analogous to altruism, whereas others warn not to confound the two concepts. Is PSM separate from altruism? How does each motivational construct relate to prosocial behaviors? We use a nationally representative panel of respondents to the Cooperative Congressional Election Study (CCES) to measure both altruism and PSM among respondents before the 2016 election and measure respondents’ participation in prosocial behaviors after the 2016 election. Using linear probability models with state fixed effects, we find that although PSM and altruism predict prosocial behaviors separately, altruism has no effect after controlling for PSM. PSM is a more consistent predictor of some prosocial behaviors than altruism, particularly in more formal contexts such as volunteering with an organization.
Solar coronal heating by Alfvén waves in bi-kappa distributed plasma
Authors: Khan Imran A , Iqbal Z , Murtaza G 
Published: November 2019

ABSTRACT
In solar physics, there is a decades-old conundrum that is still unsolved. Why is the temperature of the corona so much larger than that of the surface of the Sun? To solve this, various approaches have been adopted so far, but they have certain limitations. In the present analysis, we invoke the standard Vlasov model and the steady-state Poynting theorem to unlock the mysterious coronal heating mechanism in terms of inertial and kinetic Alfvén waves whose electromagnetic energies turn into heat during wave–particle interaction. The coronal plasmas that support these waves are modelled by a non-thermal bi-kappa velocity distribution function. The non-thermal distribution function, which is assumed to pre-exist in the system, strongly influences the wave-heating process. Particularly, during heating by the waves in the inertial limit, the non-thermal features of the distribution function give rise to a unique competition (which is entirely absent in the usual Maxwellian plasmas) between waves of different perpendicular wavenumbers (kx). For small kx, when either the non-thermal parameter κ or the electron parallel temperature T||e increases, the inertial Alfvén waves can efficiently heat the plasma in their immediate vicinity. However, for relatively large kx, an increase in either κ or T||e enables the inertial Alfvén waves to effectively heat the plasma in remote regions in the corona. Although such competition is not seen in the kinetic limit, the non-thermal features still seem to control the heating process. The possible explanations behind the above-mentioned cases are provided by the bi-kappa velocity distribution function, which holds vital clues as to how the non-thermal features, together with kx, dictate the resonance conditions that play a crucial role in the heating process.
The MUSE Atlas of Discs (MAD): Ionized gas kinematic maps and an application to diffuse ionized gas
Authors: den Brok Mark , Carollo C Marcella , Erroz-Ferrer Santiago , Fagioli Martina , Brinchmann Jarle , Emsellem Eric , Krajnović Davor , Marino Raffaella A , Onodera Masato , Tacchella Sandro , Weilbacher Peter M , Woo Joanna 
Published: November 2019

ABSTRACT
We have obtained data for 41 star forming galaxies in the MUSE Atlas of Discs (MAD) survey with VLT/MUSE. These data allow us, at high resolution of a few 100 pc, to extract ionized gas kinematics (V, σ) of the centres of nearby star forming galaxies spanning 3  dex in stellar mass. This paper outlines the methodology for measuring the ionized gas kinematics, which we will use in subsequent papers of this survey. We also show how the maps can be used to study the kinematics of diffuse ionized gas for galaxies of various inclinations and masses. Using two different methods to identify the diffuse ionized gas, we measure rotation velocities of this gas for a subsample of six galaxies. We find that the diffuse ionized gas rotates on average slower than the star forming gas with lags of 0–10 km s−1 while also having higher velocity dispersion. The magnitude of these lags is on average 5 km s−1 lower than observed velocity lags between ionized and molecular gas. Using Jeans models to interpret the lags in rotation velocity and the increase in velocity dispersion we show that most of the diffuse ionized gas kinematics are consistent with its emission originating from a somewhat thicker layer than the star forming gas, with a scale height that is lower than that of the stellar disc.
Domestication of High-Copy Transposons Underlays the Wheat Small RNA Response to an Obligate Pathogen
Authors: Poretti Manuel , Praz Coraline Rosalie , Meile Lukas , Kälin Carol , Schaefer Luisa Katharina , Schläfli Michael , Widrig Victoria , Sanchez-Vallet Andrea , Wicker Thomas , Bourras Salim 
Published: November 2019

Abstract
Plant genomes have evolved several evolutionary mechanisms to tolerate and make use of transposable elements (TEs). Of these, transposon domestication into cis-regulatory and microRNA (miRNA) sequences is proposed to contribute to abiotic/biotic stress adaptation in plants. The wheat genome is derived at 85% from TEs, and contains thousands of miniature inverted-repeat transposable elements (MITEs), whose sequences are particularly prone for domestication into miRNA precursors. In this study, we investigate the contribution of TEs to the wheat small RNA immune response to the lineage-specific, obligate powdery mildew pathogen. We show that MITEs of the Mariner superfamily contribute the largest diversity of miRNAs to the wheat immune response. In particular, MITE precursors of miRNAs are wide-spread over the wheat genome, and highly conserved copies are found in the Lr34 and QPm.tut-4A mildew resistance loci. Our work suggests that transposon domestication is an important evolutionary force driving miRNA functional innovation in wheat immunity.
Clinician Knowledge, Attitudes, and Practice Regarding Cannabis: Results from a National Veterans Health Administration Survey
Authors: Kansagara Devan , Morasco Benjamin J , Iacocca Megan O , Bair Matthew J , Hooker Elizabeth R , Becker William C 
Published: November 2019

Abstract

Background
Cannabis is increasingly available and used for medical and recreational purposes, but few studies have assessed provider knowledge, attitudes, and practice regarding cannabis.

Methods
We administered a 47-item electronic survey to assess nationwide Veterans Health Administration (VHA) clinician knowledge, beliefs, attitudes, and practice regarding patients’ use of cannabis.

Results
We received 249 completed surveys from 39 states and the District of Columbia. Fifty-five percent of respondents were female, 74% were white, and the mean age was 50 years. There were knowledge gaps among a substantial minority of respondents in specific areas: terminology, psychoactive effects of cannabis components, VHA policy, and evidence regarding benefits and harms of cannabis. Most respondents were likely or very likely to plan to taper opioids if urine drug testing was positive for tetra-hydro cannabinol (THC; 73%). A significantly greater proportion of respondents from states in which cannabis is illegal for any purpose (odds ratio [OR] = 4.9, 95% confidence interval [CI] = 2.0–10.8) or is recreationally illegal (OR = 5.0, 95% CI = 2.4–10.8) reported being likely or very likely to taper opioids as compared with respondents from states in which cannabis is legal for medical and recreational purposes.

Conclusions
Among the sample, we found knowledge gaps, areas of discomfort discussing key aspects of cannabis use with their patients, and variation in practice regarding opioids in patients also using THC. These results suggest a need for more widespread clinician education about cannabis, as well as an opportunity to develop more robust guidance and evidence regarding management of patients using prescription opioids and cannabis concomitantly.
Evaluating the Uptake and Acceptability of Standardized Postoperative Rehabilitation Guidelines Using an Online Knowledge Translation Approach
Authors: Chepeha Judy C , Silveira Anelise , Sheps David , Beaupre Lauren A ,   Shoulder and Upper Extremity Research Group of Edmonton (SURGE)
Published: November 2019

Abstract

Background
Providing physical therapists with evidence-based and consensus-derived guidelines to manage postoperative shoulder patients is essential; these guidelines should be readily available and provide clinically applicable information. Knowledge translation (KT) initiatives that encourage interaction between clinicians and researchers, that have multifaceted components and use a variety of strategies, can significantly change practice.

Objective
The objective of this study was to determine the uptake and acceptability of standardized postoperative shoulder guidelines with an accompanying online KT resource through evaluation of website analytics and a quantitative survey.

Design
A multi-pronged approach was used to assess uptake and acceptability of the guidelines and online KT resource.

Methods
Website analytics of usage and geographical location of users was measured as were physical therapist survey responses.

Results
Website analytics revealed that 5406 individuals used the online resource between October 2012 and September 2013 with the average visit lasting 8 minutes; only 47% of users were within the guideline developers’ surgical referral region. Physical therapists who used the new shoulder guidelines were very satisfied or satisfied (96%) with the guidelines, reporting they promoted patient-specific clinical decision-making extremely or very well (68%). They viewed the online KT resource positively, with 79% rating it as “very useful” or “quite useful.” Physical therapists from regions beyond those expected to use the new shoulder guidelines were also aware of the website and also rated it as very useful.

Limitations
The survey sample was relatively small and did not directly assess patient outcomes.

Conclusions
An online KT web resource developed in conjunction with standardized postoperative shoulder guidelines was perceived as useful based on website analytics and survey responses. Active KT strategies such as this can improve uptake and dissemination of best practice in physical therapy.