bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duration of dual antiplatelet therapy in elective drug‐coated balloon angioplasty
Authors: Corballis Natasha H. , Wickramarachchi Upul , Vassiliou Vassilios S. , Eccleshall Simon C. 
Published: December 2019

AbstractObjectivesWe sought to answer whether 1‐month duration of dual antiplatelet therapy (DAPT) is safe after elective drug‐coated balloon only (DCB) angioplasty.BackgroundThe duration of DAPT after elective DCB was called into question after the ESC Focused DAPT Update of 2017. Until then, a 1‐month duration of DAPT was considered safe by national consensus groups (German, Italian, and Chinese) supported by data from prospective worldwide registries.The ESC Guidelines recommended a 6‐month duration of DAPT based on evidence from in‐stent restenosis randomized controlled trials only.MethodsRetrospective, real‐world population, single‐center analysis conducted from January 1, 2012 to March 31, 2017 in a high‐volume, tertiary PCI center. Consecutive patients receiving 1‐month duration of DAPT after elective DCB angioplasty were included. We identified a primary composite outcome of cardiac death, myocardial infarction and target lesion revascularization at 6‐months.ResultsA total of 303 patients (78.5% male) with mean age of 67 ± 12.5 were included. This incorporated 86.1% de novo lesions and 56.5% nonsmall (≥3 mm diameter) coronary arteries treated. There were no reported outcomes of lesion thrombosis, target vessel MI, target lesion revascularization or cardiac death at 6‐months. There were two (0.6%) nontarget vessel MIs and one (0.3%) noncardiac death.ConclusionOne‐month duration of DAPT appears safe after elective DCB‐only angioplasty, highlighting this strategy for patients at high‐risk of bleeding. These results also show favorable clinical outcomes for de novo coronary artery disease and nonsmall coronary arteries treated with DCB‐only angioplasty. A 1‐month duration of DAPT appears a safe and attractive option.
Early clinical and procedural outcomes in large series of 34‐mm self‐expanding transcatheter aortic valve replacement
Authors: Ali Zuber , Sharma Payal , Mengesha Tadele , Dalmar Ahmed , Ammar Khawaja Afzal , Allaqaband Suhail Q. , O'Hair Daniel P. , Khandheria Bijoy K. , Jain Renuka , Bajwa Tanvir 
Published: December 2019

AbstractObjectivesWe aimed to evaluate early clinical and procedural outcomes with the 34‐mm Evolut R transcatheter aortic valve replacement (TAVR) prosthesis.BackgroundThe 34‐mm Evolut R (Medtronic, Minneapolis, MN) self‐expanding TAVR prosthesis was designed to treat patients with larger annuli.MethodsClinical, demographic, procedural, and echocardiographic data on consecutive patients who underwent TAVR with a 34‐mm Evolut R prosthesis at our institution were collected and analyzed.ResultsOne hundred ninety‐six patients underwent TAVR with this prosthesis from November 2016 to July 2018, a majority (n = 188, 96%) through transfemoral access and with conscious sedation (n = 182, 93%). Mean age, Society of Thoracic Surgery risk score, and follow‐up were 82 ± 8 years, 5.4 ± 5%, and 8.2 ± 5.3 months, respectively. Mean aortic valve (AV) peak velocity was 4.0 ± 0.6 m/s, mean AV gradient was 38 ± 13 mmHg, AV area was 0.79 ± 0.23 cm2; calcium score was 3,503 ± 1,970 Agatston units, and perimeter was 85 ± 4.3 mm. Device implantation was successful in all but one patient. Postprocedure mean AV peak velocity, AV mean gradient, and AV area were 1.9 ± 0.4 m/s, 7 ± 3 mmHg, and 2.6 ± 0.7 cm2, respectively. New pacemaker requirement rate was 16%, and moderate paravalvular leak was present in six patients (3%), which improved to mild in three patients at 6‐month follow‐up. In‐hospital, 30‐day, 6‐month, and 12‐month survival rates were 98%, 96% (hospital discharge), 96% (30‐day), 89% (6‐month), and 83% (12‐month).ConclusionThese data demonstrate high success and good procedural, echocardiographic, and clinical outcomes of 34‐mm Evolut R in patients with large annuli.
Nitrogen‐Doped Hard Carbon on Nickel Foam as Free‐Standing Anodes for High‐Performance Sodium‐Ion Batteries
Authors: Li Ruizi , Huang Jianfeng , Li Jiayin , Cao Liyun , Luo Yijia , He Yuanyuan , Lu Guoxing , Yu Aimin , Chen Shaoyi 
Published: December 2019

AbstractNitrogen‐doped hard carbon on Ni foam (NC/NF) with numerous active sites, expanded interlayer distance (0.49 nm), and highly ordered pseudo‐graphic structure is synthesized by a melamine‐assisted hydrothermal pretreatment and subsequent pyrolysis procedure. The high content configurations of pyrrolic‐nitrogen and pyridinic‐nitrogen in NC/NF could provide abundant active sites and defects for efficient Na+ adsorption/desorption and improved transport kinetics. The obvious flocculent structures on carbon surface, corresponding to the highly ordered pseudo‐graphic structure, could enhance the transport kinetics for electrons. The strong electrostatic repulsion of pyrrolic‐nitrogen could expand interlayer distance, facilitating Na+ insertion/extraction process. The balance between high nitrogen content and sufficient graphitization degree comes into strong carbon frameworks with enhanced structural stability and electronic conductivity. When served as free‐standing anodes for sodium‐ion batteries (SIBs), NC/NF presents high rate capability of 128.5 mAh g−1 at 10 A g−1, and excellent cycling stability of 225.4 mAh g−1 after 1000 cycles under high current density of 5 A g−1. These results demonstrate a new light to prepare advanced anodes for SIBs.
Design of High‐Performance Co‐Based Alloy Nanocatalysts for the Oxygen Reduction Reaction
Authors: Zhao Zheng , Xu Haoxiang , Feng Zongyu , Zhang Yongqi , Cui Meisheng , Cao Dapeng , Cheng Daojian 
Published: December 2019

AbstractCo‐based nanoalloys show potential applications as nanocatalysts for the oxygen reduction reaction (ORR), but improving their activity is still a great challenge. In this paper, a strategy is proposed to design efficient Co‐M (M=Au, Ag, Pd, Pt, Ir, and Rh) nanoalloys as ORR catalysts by using density functional theory (DFT) calculations. Through the Sabatier analysis, the overpotential as a function of ΔGOH* is identified as a quantitative descriptor for analyzing the effect of dopants and atomic structures on the activity of the Co‐based nanoalloys. By adopting the suitable dopants and atomic structures, ΔGOH* accompanied by overpotential could be adjusted to the optimal range to enhance the activity of the Co‐based nanoalloys. With this strategy, the core–shell structured Ag42Co13 nanoalloy is predicted to have the highest catalytic activity for ORR among these Co‐based nanoalloys. To give a deeper insight into the properties of Ag‐Co nanoalloys, the structure, thermal stability, and reaction mechanism of Ag‐Co nanoalloys with different compositions are also studied by using molecular simulations and DFT calculations. It is found that core–shell Ag42Co13 exhibits the highest structural and thermal stability among these Ag‐Co nanoalloys. In addition, the core–shell Ag42Co13 shows the lowest ORR reaction energy barriers among these Ag‐Co nanoalloys. It is expected that this kind of strategy could provide a viable way to design highly efficient heterogeneous catalysts in extensive applications.
Titanium‐Catalyzed Hydroaminoalkylation of Ethylene
Authors: Rosien Michael , Töben Iris , Schmidtmann Marc , Beckhaus Rüdiger , Doye Sven 
Published: December 2019

AbstractThe first examples of titanium‐catalyzed hydroaminoalkylation reactions of ethylene with secondary amines are presented. The reactions can be achieved with various titanium catalysts and they do not require the use of high pressure equipment. In addition, the first solid‐state structure of a titanapyrrolidine that is formed by insertion of an alkene into the Ti−C bond of a titanaaziridine is reported.
Effect of Fe/Zn ratio in composite catalyst for synthesizing polyoxymethylene dimethyl ethers
Authors: Zhang Wujie , Li Xiangjun , Nawaz Muhammad A. , Pan Jiahao , Cao Jiancheng , Liu Dianhua 
Published: December 2019

AbstractPolyoxymethylene dimethyl ethers (PODEn) are extremely effective diesel additives to reduce soot formation during combustion. We introduce a series of Fe‐Zn composite solid acid catalysts (SO42−/xFe2O3‐yZnO), for the condensation reaction of methanol and paraformaldehyde (PF) with a cheap and feasible route to efficiently synthesize PODEn. These catalysts were characterized by different characterization techniques, namely BET, XRD, SEM, EDS, FTIR, and NH3‐TPD and the results showed that Fe/Zn molar ratios strongly influenced the physicochemical characteristics of catalysts, thus affecting the methanol conversion and PODE1‐6 and PODE3‐6 selectivity. Accordingly, the methanol conversion was decreased and the selectivity of PODE3‐6 was increased after increasing the Zn molar content. Comparatively, SO42−/Fe2O3‐2ZnO exhibited superior catalytic activity among the various investigated catalysts due to the high acid density of strong acid sites. The optimal reaction conditions were observed to be at a 3.0 wt% catalyst loading (catalyst/reactant mass ratio), 2.5 hours ours of reaction time, a reaction temperature of 403 K, and a molar ratio of 3:1 of CH2O to methanol, achieving a high selectivity of 99.09% PODE1‐6 and 28.23% PODE3‐6 with 55.16% methanol conversion during the reaction.
Solubility of propane in N‐formyl morpholine
Authors: Jou Fang‐Yuan , Mather Alan E. , Schmidt Kurt A. G. 
Published: December 2019

AbstractN‐formyl morpholine (NFM) is a solvent that has been used to separate acid gases from gas streams. An advantage of NFM is the high solubility of acid gases compared with the low solubility of light hydrocarbons. The solubility of the light hydrocarbons in NFM is important, as the hydrocarbons constitute a loss to the process, and result in hydrocarbon emissions to the atmosphere. However, there are only a few experimental data sets dealing with the solubility of hydrocarbons in NFM. To provide data to be used in the design of plants in the natural gas processing industry, the solubility of propane (C3H8) in NFM was measured at 298.15, 313.15, and 343.15 K at pressures up to 20.15 MPa. The Peng‐Robinson equation of state was employed to correlate the experimental data and to obtain binary interaction parameters. The binary interaction parameters were used to obtain the parameters of the Krichevsky‐Ilinskaya equation and Henry's law constants for propane were calculated. Henry's law constants for propane were compared with those of hydrogen sulphide, carbon dioxide, methane, and ethane in NFM.
In vitro optical characterization of dental resin composite aged in darkness
Authors: Mikhail Sarah S. , Johnston William M. 
Published: December 2019

AbstractThe overall objective of this study is to confirm the method of determining the accuracy of Kubelka‐Munk reflectance theory (KMRT) for composite materials after undergoing aging unrelated to surface exposure. The specific aims of this study include comparisons of optical characterizations for two dental resin composite materials before and after aging in darkness. Aging of five shades of two nanohybrid dental resin composite materials was accomplished under relatively normal room conditions in a dark enclosure for over 3 years. The accuracy of KMRT was assessed and optical absorption and scattering and color and translucency characterizations were performed. The magnitudes of the error of nonlinear regression of reflectance after aging to KMRT are well within the limits of expected measurement error as applied to regression analysis. The characterizations of inherent optical scattering, inherent color, and translucency indicate that aging in darkness will have some effect for at least some shades of the materials studied. KMRT is a reliable method to predict the reflectance of dental resin aged in darkness and permits subsequent clinically relevant optical characterizations of materials aged in this manner. Although changes in optical scattering were detected due to this aging, such changes appear to have a negligible clinical effect on color and translucency.
Autotuning of configuration for program execution in GPUs
Authors: Balaiah Thanasekhar , Parthasarathi Ranjani 
Published: December 2019

SummaryGraphics Processing Units (GPUs) are used as accelerators for improving performance while executing highly data parallel applications. The GPUs are characterized by a number of Streaming Multiprocessors (SM) and a large number of cores within each SM. In addition to this, a hierarchy of memories with different latencies and sizes is present in the GPUs. The program execution in GPUs is thus dependent on a number of parameter values, both at compile time and runtime. To obtain the optimal performance with these GPU resources, a large parameter space is to be explored, and this leads to a number of unproductive program executions. To alleviate this difficulty, machine learning–based autotuning systems are proposed to predict the right configuration using a limited set of compile‐time parameters. In this paper, we propose a two‐stage machine learning–based autotuning framework using an expanded set of attributes. The important parameters such as block size, occupancy, eligible warps, and execution time are predicted. The mean relative error in prediction of different parameters ranges from of 16% to 6.5%. Dimensionality reduction for the features set reduces the features by up to 50% with further increase in prediction accuracy.
Physical deployment of enhanced visible light communication system using forward error correction codes
Authors: Khalid Arslan , Rashid Faizan , Muhammad Asif Hafiz , Ali Assad , Al‐Otaibi Sattam 
Published: December 2019

SummaryWith the development of new generation lighting sources, visible light communication (VLC) system has become a complementary solution to traditional radio frequency wireless system. However, the error performance of VLC system is degraded because of multipath effects and interference from other lighting sources that, in turn, reduce the communication range. This work targets the issue of performance degradation of VLC systems in terms of communication range and demonstrates a VLC system design that utilizes forward error correction (FEC) codes as the main tool to fix this issue. Furthermore, the work also covers practical implementation of the proposed VLC system using UART modules programmed in MATLAB. The hardware results demonstrate that the communication range of the proposed VLC system is enhanced up to 0.5 m. Over and above, it is also shown through simulations that the coding gain of the proposed design is more when compared with existing VLC system(s).
Synthesis and antimicrobial evaluation of piperic acid amides and their lower homologues
Authors: Achanta Prabhakar S. , Raj Sneha , Horam Soyar , Arockiaraj Jesu , Bobbala Ravi Kumar , Akkinepally Raghuram Rao , Pasupuleti Mukesh , Achanta Appa Rao V. N. 
Published: December 2019

AbstractSeven piperic acid amides along with their lower homologs (12) were synthesized using HATU‐DIPEA coupling reagent. All the synthesized derivatives were evaluated for their antibacterial activities against Staphylococcus aureus, Pseudomonas aeruginosa, and vancomycin‐resistant P. aeruginosa. They were found to be more active on P. aeruginosa than on S. aureus. However, they did not exhibit potent activity on Vancomycin resistant P. aeruginosa. Among the tested compounds, methylenedioxycinnamic acid amide of anthranilic acid (MDCA‐AA, 2a) was found to be most active against S. aureus with MIC of 3.125 μg/ml. The PAS and INH amides of piperic acid were screened against Mycobacterium tuberculosis H37Ra strain. They were found to be most active among all the tested compounds but were found to be less active than the standard drug, isoniazid.
Heat tolerance and acclimation capacity in subterranean arthropods living under common and stable thermal conditions
Authors: Pallarés Susana , Colado Raquel , Pérez‐Fernández Toni , Wesener Thomas , Ribera Ignacio , Sánchez‐Fernández David 
Published: December 2019

AbstractCave‐dwelling ectotherms, which have evolved for millions of years under stable thermal conditions, could be expected to have adjusted their physiological limits to the narrow range of temperatures they experience and to be highly vulnerable to global warming. However, most of the few existing studies on thermal tolerance in subterranean invertebrates highlight that despite the fact that they show lower heat tolerance than most surface‐dwelling species, their upper thermal limits are generally not adjusted to ambient temperature. The question remains to what extent this pattern is common across subterranean invertebrates. We studied basal heat tolerance and its plasticity in four species of distant arthropod groups (Coleoptera, Diplopoda, and Collembola) with different evolutionary histories but under similar selection pressures, as they have been exposed to the same constant environmental conditions for a long time. Adults were exposed at different temperatures for 1 week to determine upper lethal temperatures. Then, individuals from previous sublethal treatments were transferred to a higher temperature to determine acclimation capacity. Upper lethal temperatures of three of the studied species were similar to those reported for other subterranean species (between 20 and 25°C) and widely exceeded the cave temperature (13–14°C). The diplopod species showed the highest long‐term heat tolerance detected so far for a troglobiont (i.e., obligate subterranean) species (median lethal temperature after 7 days exposure: 28°C) and a positive acclimation response. Our results agree with previous studies showing that heat tolerance in subterranean species is not determined by environmental conditions. Thus, subterranean species, even those living under similar climatic conditions, might be differently affected by global warming.
Conjugated Linoleic Acid Supplemented Diet Influences Serum Markers in Orchidectomized Sprague‐Dawley Rats
Authors: Rojas Mibsam Margot , Villalpando Diva María , Ferrer Mercedes , Alexander‐Aguilera Alfonso , García Hugo Sergio 
Published: December 2019

AbstractConjugated isomers of linoleic acid have beneficial effects on human health, with demonstrated anticarcinogenic, antiatherogenic, antioxidant, and anti‐inflammatory properties. Previous studies have shown that the loss of sex hormones induced by orchidectomy affects vascular function and serum lipids. The objective of this work is to evaluate the effect of conjugated linoleic acid (CLA) on serum lipids, cardiac, renal, and hepatic markers in orchidectomized Sprague‐Dawley rats. Male sex hormone deprivation is induced by orchidectomy to 24‐week‐old rats. The rats are fed a diet containing 1.8% w/w CLA, or a control diet for 8 weeks. At the end of the treatment, serum markers are measured using commercially available kits. The concentrations found in the orchidectomized‐CLA (ORX‐CLA) group of total cholesterol, low‐density lipoproteins (LDL), as well as the atherogenic index, concentrations of creatine kinase, lactate dehydrogenase, C‐reactive protein, glucose, urea, uric acid, creatinine, albumin, calcium, total protein, and bilirubin are significantly lower compared to the orchidectomized‐control (ORX‐C) group. The concentrations of high‐density lipoproteins (HDL), calcium, total protein, albumin, total bilirubin, and indirect bilirubin are significantly higher in the ORX‐CLA group than in the ORX‐C group. The CLA‐supplemented diet exerts a beneficial effect on different biochemical parameters negatively affected by orchidectomy, which may result in vascular protection.Practical Applications: The relationship between testosterone deficiency and the alteration of serum lipids is demonstrated; however, it is demonstrated in this study that the markers of renal damage, cardiac damage, and oxidative stress are also negatively affected by the lack of this hormone. This information has enriched the understanding about the relationship between testosterone deficiency and the development of different diseases such as metabolic syndrome, type 2 diabetes, kidney failure, osteoporosis, cardiovascular diseases, and cancer. On the other hand, CLA has been studied mainly as a nutraceutical and sports supplement; the information in this study will help to expand the knowledge about the benefits of these isomers of linoleic acid, providing guidelines for its use as a protection against negative effects triggered by orchidectomy.
A Novel Electrochemical Sensor for Detection of Baicalein in Human Serum Based on DUT‐9/Mesoporous Carbon Composite
Authors: Wang Haixu , Yuan Shuang , Zhou Ming , Guo Liping 
Published: December 2019

AbstractDUT‐9/mesoporous carbon (DUT‐9/MC) nanocomposites were synthesized by in‐situ growth of nickel‐based metal‐organic frameworks (DUT‐9) on the MC for the first time. Compared with original DUT‐9 crystals, the presence of MC in the composites can avoid the agglomeration of DUT‐9 sheets, increase the specific surface area and reduce the electron transfer resistance. DUT‐9/MC shows enhanced electrocatalytic activity toward redox of baicalein compared with DTU‐9. The possible electrocatalytic redox mechanism of baicalein involves two electrons and two protons. Under the optimized conditions, the proposed sensor shows a wide linear relationship in the concentration range of 0.05‐20 μM (R2=0.993, sensitivity of 0.1188 μA/μM) with a low detection limit of 0.015 μM. It is worth noting that the oxidation overpotential of baicalein (0.107 V) is significantly lower than that of most literatures in pH 7.0. Meanwhile, the proposed sensor shows satisfactory results for the detection of baicalein in human serum samples. This research provides a highly efficient strategy for fabricating novel electrochemical sensor based two‐dimensional lamellar structure MOFs.
Silica microbeads capture fetal nucleated red blood cells for noninvasive prenatal testing of fetal ABO genotype
Authors: Cheng Lin , Wei Xiaoyun , Wang Zixiang , Feng Chun , Gong Qing , Fu Yourong , Zhao Xingzhong , Zhang Yuanzhen 
Published: December 2019

AbstractABO hemolytic disease of the newborn (ABO‐HDN), which may cause neonatal jaundice and polycythemia, or even stillbirth or neonatal death, is widespread in China. Prenatal testing for the fetal ABO blood group can reduce unnecessary concerns or ensure prompt treatment. Herein, we presented a method to employ high‐density silica microbeads (SiO2 MBs) for capturing fetal nucleated red blood cells (fnRBCs) in maternal peripheral blood, and we detected the ABO genotype of the fetus using these captured cells. We evaluated 52 patients using the SiO2 MBs. Among 26 pregnant women with type O blood, 8 (30.8%) of the fetuses had type A blood, 5 (19.2%) had type B blood, and 13 (50%) had type O blood. SRY genes were detected in all 27 male fetuses. This study represents a simple and effective method for noninvasive prenatal detection of the fetal ABO genotype. We believe that this method has great potential for noninvasive prenatal testing of the fetal Rh blood group and other fetal diseases as well.