bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Implant Failure in Cervical Disc Arthroplasty (M6-C, Spinal Kinetics) Causing Radiculopathy and Myelopathy
Authors: Pingel Andreas , Hoffmann Christoph-Heinrich , Scholz Matti , Kandziora Frank 
Published: December 2020

AbstractCervical disc arthroplasty (CDA) is an approved surgical treatment option in selected patients with cervical spinal disc degeneration. Even though CDA is a standard procedure since 20 years, there is a lack of information about long term performance. The published reoperation rates after CDA are low and comparable to anterior cervical fusion. The authors describe a severe failure and dysfunction with a partial core dislocation of a cervical prosthesis into the spinal canal (M6-C, Spinal Kinetics, Sunnyvale, CA, USA). Six years after implantation of a cTDR (cervical Total Disk Replacement) of the M6 type at C4/5 level, a 52 year-old women presented herself with new clinical signs of cervical myelopathy and radicular pain. Complete posterior dislocation of the central core of the implant into the spinal canal was identified as a cause. The failed device was removed completely and an ACCF (anterior cervical corpectomy and fusion) was performed. Intraoperatively, rupture of
the posterior portion of the mesh tissue with posterior dislocation of the whole prosthesis core was detected. This is the second described case of a severe implant failure with core dislocation in this type of cTDR device. Even though there are thousands of successful implantations and middle term outcomes, it seems to be necessary to continue with long term radiological follow up to exclude similar failure in this type of prosthesis.
Medial Hoffa Fracture: Description of a Novel Classification System and Rationale for Treatment Based on Fragment-Specific Fixation Strategy
Authors: Pires Robinson Esteves , Bidolegui Fernando , Pereira Sebastián , Giordano Vincenzo , Giordano Marcos , Schröter Steffen 
Published: December 2020

Abstract
Purpose This study aims to present a novel classification system and a rationale for treatment of medial Hoffa fractures.
Methods We developed a simple comprehensive classification system for medial Hoffa fractures based on the fragment size and presence of fracture comminution. Furthermore, we propose
a treatment algorithm based on two pillars: our case series of nine patients presenting medial Hoffa fractures and the best evidence-based pertinent literature. Fracture healing, range of
motion, function, and complications were evaluated after a minimum of 6 months follow-up.
Results All fractures healed with no loss of reduction. Knee flexion ranged from 90 – 130° (mean 110°, standard deviation 15.2). Knee extension ranged from 0 – 10° (mean 1°, standard
deviation 3.3). Knee function according to the Lysholm score ranged from 74 – 96 points (mean 85, standard deviation 6.3). There were no complications such as infection, fixation failure, or
medial femoral condyle osteonecrosis. One patient required hardware removal due to soft tissue irritation and one patient underwent knee mobilization under anesthesia after 8 weeks of
fracture fixation due to knee stiffness.
Conclusion The presented rationale for treatment based on the new classification system is a simple and effective strategy on the decision-making process for adequate management of
medial Hoffa fractures.
Synthesis, Biological Evaluation and Docking Study of New Pyrimidine Compounds as Anticancer Agents
Authors: Boumi Shahin , Moghimirad Jafar , Ostad Seyed Nasser , Amanlou Massoud , Tavajohi Shohreh , Amini Mohsen 
Published: December 2020

AbstractObjectives The microtubule is composed of αβ tubulin heterodimers and is an attractive target for the design of anticancer drugs. Over the years, various compounds have been developed and their effect on tubulin polymerization has been studied. Despite a great efforts to make an effective drug, no drug has been introduced which inhibit Colchicine binding site.Methods In the current work a series of pyrimidine derivatives were designed and synthesized. Furthermore their cytotoxic activities were evaluated and molecular docking studies were performed. Twelve compounds of pyrimidine were synthesized in 3 different groups. In the first group, 4,6-diaryl pyrimidine was connected to the third aryl group via thio-methylene spacer. In the second group, this linker was substituted by sulfoxide-methylene moiety and in the third group sulfone-methylene group was used as spacer.Results The cytotoxic activity of these compounds were evaluated against 3 different cancerous cell lines (HT-29, MCF-7, T47D) as well as normal cell line (NIH3T3). Compounds in group 2 showed the best cytotoxicity and compound 7d showed the most potent cytotoxic activity against all cell lines. Molecular modelling studies revealed that compound 7d could strongly bind to the colchicine binding site of tubulin.Conclusion Altogether, with respect to obtained results, it is attractive and beneficial to further investigation on pyrimidine scaffold as antimitotic agents.
Highly Efficient Copper-Catalyzed Dehydrogenative Cross-Coupling of Azoles with α-Amino Carbonyl Compounds
Authors: Zhu Zhi-Qiang , Le Zhang-Gao , Ji Jiu-Jian , Xie Zong-Bo , Tang Juan , Yuan En 
Published: December 2020

AbstractA novel and highly efficient dehydrogenative cross-coupling­ reaction between α-amino carbonyl compounds and azoles by copper catalysis using di-tert-butyl peroxide (DTBP) as an oxidant is described­. A diverse range of azoles undergo the dehydrogenative imidoylation smoothly with various α-amino carbonyl compounds for the exclusive formation of the corresponding N-imidoyl azoles in high yields under air. The synthetic method has the advantages of good functional-group tolerance, wide substrate scope, excellent yields, and simple operation­, thus providing a convenient and practical protocol for the synthesis of functionalized azoles.
Brain Arteriovenous Malformations: Impact of Neurologic Status, Bleeding, and Type of Treatment on Final Outcome
Authors: García-Duque Sara , García-Leal Roberto , Iza-Vallejo Begoña , Castro-Reyes Enrique , Fortea Fernando , Villoria Francisco , Langer David J. , Diamantopoulos Jorge , Belda-Iniesta Cristobal , Ayuso-Sacido Angel 
Published: December 2020

Abstract
Background Well-designed studies assessing the treatment outcome of brain arteriovenous malformations (AVMs) are infrequent and have not consistently included all of the available treatment modalities, making their results not completely generalizable. Moreover, the predictors of poor outcome are not well defined.
Methods We performed an observational retrospective study of AVM patients. We included patients with clinical, radiologic, and outcome data, with a minimum follow-up of 1 year. Neurologic outcome was documented using the modified Rankin Scale (mRS) at the AVM diagnosis and 30 days after the treatment.
Results There were 117 patients, with equal male/female proportion. The mean follow-up time was 51 months. Treatment distribution in the Spetzler–Martin grades I–III was as follows: 52 (54.6%) surgery, 31 (32.35%) radiosurgery, 2 (0.02%) embolization, and 11 (12%) conservative follow-up. Treatment distribution in Spetzler–Martin grades IV and V was as follows: 4 (20%) surgery, 7 (35%) radiosurgery, and 10 (45%) conservative follow-up. Poor neurologic outcome (mRS ≥ 3) was significantly associated with poor clinical status at diagnosis (Glasgow Coma Scale [GCS] score< 14; odds ratio [OR]: 0.20; 95% confidence interval [CI]: 0.001–0.396; p = 0.010). The rupture of the AVM was associated with poor neurologic outcome. The Lawton–Young Supplementary scale (LYSS) proved to be the most effective in predicting poor outcome. The existence of seizures, treatment-related complications, and conservative treatment was associated with the worsening of the mRS score, whereas the existence of hemorrhage was associated with the likelihood of disability.
Conclusion Our results suggest that poor neurologic status at diagnosis, AVM rupture, and conservative treatment were associated with worse outcome. Hemorrhage as initial presentation is related to disability, not with mRS worsening. The LYSS appeared to be the best method to predict outcome.
Experience with Eslicarbazepine Acetate Treatment at a Pediatric Epilepsy Center
Authors: Tanritanir Ahmet , Wang Xiaofan , Loddenkemper Tobias 
Published: December 2020

AbstractEslicarbazepine acetate (ESL) is a novel, once-daily antiseizure medication. We evaluated the efficacy and safety profile of ESL treatment in epilepsy patients at a single tertiary epilepsy center. In this retrospective observational study, we included 32 patients with pharmacologically intractable epilepsy receiving ESL at Boston Children's Hospital from June 2014 to June 2018. We assessed treatment outcome in terms of efficacy and tolerability at first and last follow-up (f/u). Median age was 17 (interquartile range: 10.8–20.7; range: 6.5–36) years. Twelve (37.5%) patients, including three with seizure freedom, were responders at last f/u. Eleven patients discontinued ESL due to seizure worsening (9, 28%), adverse events (AEs) (2, 6%) or both (4, 12%). Responders showed greater seizure reduction at last f/u with fewer AEs as compared with nonresponders. Ten (31%) patients developed AEs, the most common being sleep problems (5, 15%). One-year retention rate with ESL treatment was 54%. In conclusion, ESL had a good response rate in patients with pharmacologically intractable epilepsy, with about one-third of patients developing AEs.
KCNQ2 Encephalopathy and Responsiveness to Pyridoxal-5′-Phosphate
Authors: Chow Chit Kwong , Luk Ho Ming , Wong Suet Na 
Published: December 2020

Abstract
KCNQ2 mutations encompass a wide range of phenotypes, ranging from benign familial neonatal seizure to a clinical spectrum of early-onset epileptic encephalopathy that occurs in the early neonatal period. We report an infant with KCNQ2 encephalopathy presenting as neonatal seizure, initially controlled by two anticonvulsants. Electroencephalogram (EEG) showed repetitive multifocal epileptiform discharges, which remained similar after administration of intravenous pyridoxine injection. Seizure recurred at the age of 3 months preceded by an episode of minor viral infection, which occurred multiple times per day. No significant change in seizure frequency was observed after 5-day oral pyridoxine trial, but subsequently, there was dramatic seizure improvement with oral pyridoxal-5′-phosphate (PLP). We hope to alert clinicians that in patients with neonatal epileptic encephalopathy, particularly with known KCNQ2 mutations, intravenous injection of pyridoxine (preferably with EEG monitoring), followed by both oral trial of pyridoxine and PLP should be considered. KCNQ2 mutations should also be considered in vitamin B6-responsive patients.
Feeding Practices, Lines, and Hospital-Acquired Infection during the Sustenance Phase of Infection Control Quality Improvement
Authors: KS Deepa , Balachander Bharathi , Rao PN Suman 
Published: December 2020

Abstract
Objectives Nosocomial infections are a significant threat to the survival and neurodevelopment of neonates .The present study attempts to correlate enteral feeding practices as measured by nil per oral (NPO days) with bloodstream infection (BSI) rates and central line-associated bloodstream infection (CLABSI) over a period of 2 years and 3 months.
Methods This was a prospective observational study done in a tertiary level neonatal intensive care unit (NICU). Data were recorded on the presence of central lines or peripheral intravenous (IV) lines, receipt of intravenous fluids (IVF), total parenteral nutrition (TPN) or IV antibiotics, and mechanical ventilation status. BSI and CLABSI, regarded as sentinel events, were recorded and root cause analysis done.
Results A total of 3,448 infants constituting 17,846 patient days with mean gestational age and birth weight of 34.3 ± 3 weeks and 1,868 ± 434 g, respectively were studied. NPO per 1,000 days shows a significant positive correlation with BSI (ρ = 0.513; p = 0.004), CLABSI (ρ = 0.425; p = 0.021), antibiotic days (ρ = 0.7; p < 0.000), IV fluid days (ρ = 0.459; p = 0.014), and central line days (ρ = 0.634; p < 0.001). The IV fluid days showed correlation with BSI (ρ = 0.4, p ≤ 0.03) and CLABSI (ρ = 0.43, p = 0.02).
Conclusion BSI in NICU correlates with higher NPO and IV fluid days. Strengthening of enteral feeding practices reduces health care-associated infections.
Dental Implants Surface in vitro Decontamination Protocols
Authors: Batalha Vanessa Coelho , Bueno Raquel Abreu , Fronchetti Junior Edemar , Mariano José Ricardo , Santin Gabriela Cristina , Freitas Karina Maria Salvatore , Ortiz Mariana Aparecida Lopes , Salmeron Samira 
Published: December 2020

AbstractObjective The number of patients rehabilitated with dental implants has contributed to increased incidence of peri-implant diseases. Due to complex and difficult treatment, peri-implantitis is a challenge and an efficient clinical protocol is not yet established. Aim of this study was to evaluate the efficacy of two protocols for in vitro decontamination of dental implants surface.Materials and Methods Twenty titanium implants (BioHE-Bioconect) were used. Implants were divided into five groups (n = 4). NC group (negative control): sterile implants; PC group (positive control): biofilm contaminated implants; S group: biofilm contaminated implants, brushed with sterile saline; SB group: biofilm contaminated implants, brushed with sterile saline and treated with air-powder abrasive system with sodium bicarbonate (1 minute); and antimicrobial photodynamic therapy (aPDT) group: biofilm contaminated implants, brushed with sterile saline and treated with antimicrobial photodynamic therapy (red laser + toluidine blue O). The implants were contaminated in vitro with subgingival biofilm and distributed in groups PC, S, SB, and aPDT. Each group received the respective decontamination treatment, except groups NC and PC. Then, all implants were placed in tubes containing culture medium for later sowing and counting of colony-forming units (CFUs).Statistical Analysis One-way analysis of variance and Tukey tests were performed, at 5% significance level.Results Significantly fewer CFUs were observed in the aPDT group (19.38 × 105) when compared with groups SB (26.88 × 105), S (47.75 × 105), and PC (59.88 × 105) (p < 0.01). Both the aPDT and SB groups were statistically different from the NC group (p < 0.01).Conclusion Proposed protocols, using air-powder abrasive system with sodium bicarbonate and aPDT, showed to be efficacious in the decontamination of dental implants surface in vitro.
Critério da Associação Brasileira de Nutrologia para diagnóstico e tratamento da síndrome metabólica em crianças e adolescentes
Authors: Nogueira-de-Almeida Carlos Alberto , Hirose Thiago Santos , Zorzo Renato Augusto , Vilanova Karla Cristina Malta , Ribas-Filho Durval 
Published: December 2020

Resumo
Introdução Síndrome Metabólica é um conjunto de fatores bioquímicos, fisiológicos, clínicos e metabólicos que se iniciam com a resistência periférica à insulina e que, quando concomitantemente presentes, elevam o risco de desenvolvimento de aterosclerose, eventos cardiovasculares, diabetes mellitus tipo 2 e mortalidade por qualquer causa. Em crianças, não há consenso sobre critérios diagnósticos e tratamento, por isso a importância de seu estabelecimento e padronização.
Objetivo Publicar um consenso da Associação Brasileira de Nutrologia para diagnóstico e tratamento da Síndrome Metabólica em crianças e adolescentes.
Métodos Revisão de literatura e discussão entre os autores.
Resultados Para o diagnóstico, recomenda-se o uso dos seguintes parâmetros: excesso de adiposidade corporal, dislipidemia, alteração do perfil glicêmico-insulinêmico e elevação da pressão arterial. Será considerada portadora de síndrome metabólica o adolescente ou a criança, com sete anos de idade ou mais, que apresentar valores alterados em pelo menos 3 dos 4 critérios. Mudanças do estilo de vida, melhora em quantidade e qualidade alimentar e aumento da atividade física são utilizados como terapêutica inicial, sendo que o uso de metformina é indicado para o controle da resistência insulínica quando essas medidas não forem suficientes. Liraglutida pode ser utilizada em maiores de 12 anos para promover perda de peso, sendo a cirurgia bariátrica reservada para casos especiais de obesidade grave.
Conclusão Reconhecimento e tratamento precoces da Síndrome Metabólica em pediatria proporcionam prevenção de eventos adversos cardiovasculares e diabetes nos pacientes e melhora a qualidade de vida dos mesmos e o presente consenso busca padronizar essas condutas.
The Central Synagogue of Nazareth Illit and its architectural dialogue with Nazareth’s Basilica of the Annunciation
Authors: Simhony Naomi 
Published: December 2020

AbstractThe hometown of Jesus, Nazareth, is an international center of Christian pilgrimage that has capitalized on showcasing its sacred sites. Architect Antonio Barluzzi was commissioned to design Nazareth’s modern Basilica of the Annunciation in 1954, and a cornerstone for the project was laid in a well-attended ceremony. It seems that the establishment of the modern church was the catalyst for the eagerness with which the Israeli authorities approached establishing a Jewish monument in the region. In 1957, a design process for the Central Synagogue in Nazareth Illit (subsequently renamed Nof HaGalil) began, with the aim of proudly competing with the churches and mosques in the Nazareth region. Both the basilica and the synagogue were erected by Israeli construction firmSolel Bonehand were inaugurated in 1968 and 1969, respectively. This article examines the impact of the inception, establishment and building of Nazareth’s Basilica of the Annunciation on the drive to strengthen Jewish presence in the Nazareth region, which in turn stood behind the construction of the Nazareth Illit synagogue. This research is based on a comparative investigation of the histories of both structures, including early design proposals, architecture, and the religious artworks therein. This comparative investigation reveals the influence of the basilica on the synagogue and the shared aspects of their design and execution. While existing literature dedicated to the Central Synagogue in Nazareth Illit has focused on its significance and meaning as an Israeli architectural landmark, this article presents a new perspective, examining how a modern architectural trend was used as an agent in the struggle between local Jewish and Christian monumental dominance. It also contributes to the literature by shedding light on a heretofore overlooked quest for an appropriate architectural style for religious buildings in the Land of Israel during the mid-twentieth century.
Project-based learning: an analysis of cooperation and evaluation as the axes of its dynamic
Authors: de la Torre-Neches Berta , Rubia-Avi Mariano , Aparicio-Herguedas Jose Luis , Rodríguez-Medina Jairo 
Published: December 2020

AbstractProject-based learning is an active method that develops the maximum involvement and participation of students in the learning process. It requires the teacher to energize the learning scenario by promoting the cooperation of students to investigate, make decisions and respond to the challenges of the project. It also requires activating an evaluation system that promotes awareness, reflexivity and a critical spirit, facilitating deeper learning. This case study aims to understand the functioning of cooperative work established during the application of the method, as well as to know how the evaluation process progresses in the perspective of a group of teachers of secondary education that set up this methodology in their classes. The data obtained from interviews with the teachers involved in the study, teachers’ notebooks, and open-question questionnaire applied to high-school students are analyzed. Although the students were organized in small groups in order to develop their collaborative skills, intragroup frictions and conflicts were not sufficiently addressed or supervised in time by the teachers, thus resulting in an incomplete development of the synergies and collaboration necessaries to the project. From the point of view of the evaluation, the importance of the implementation of training and shared evaluation systems is well recognized, although a more traditional evaluation model, which does not sufficiently address the project development process prevails, and the value of the qualification on the final product achieved still weights.
Nonconceptualism as the key to a new physicalist strategy in the knowledge argument
Authors: de Sá Pereira Roberto Horácio 
Published: December 2020

AbstractThis paper presents and defends an alternative version to the so-called strategy of phenomenal concepts (aka PCS) in defense of type B materialism in Jackson’s knowledge argument. Endorsing Ball and Tye’s criticism, I argue in favor of the following claims. First: Mary’s newly acquired content is nonconceptual in the light of all available criteria. Second: Mary’s acquisition of such content is precisely what allows us to explain, at least in part, both her epistemic progress (once released from her confinement) and the increase in her expertize regarding her old PHENOMENAL RED. However, although the acquisition of such nonconceptual content is indispensable, it is sufficient to explain Mary’s epistemic progress. Third: assuming that concepts are mental files, after undergoing the visual experiences of red for the first time, such newly acquired nonconceptual content goes through a process of “digitization” so that it can be stored in the mental file PHENOMENAL RED. Fourth and final claim: it is based on this concept of PHENOMENAL RED, now phenomenally enriched by the newly acquired nonconceptual content, that Mary is able to identify introspectively the phenomenal red of her new experience.
IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Authors: Xu Jing , Chen Zhouqing , Yu Fang , Liu Huan , Ma Cheng , Xie Di , Hu Xiaoming , Leak Rehana K. , Chou Sherry H. Y. , Stetler R. Anne , Shi Yejie , Chen Jun , Bennett Michael V. L. , Chen Gang 
Published: December 2020

Significance
Hemorrhagic stroke, resulting from intracerebral hemorrhage, is a devastating medical condition currently without effective cure. Here we report that intranasal delivery of IL-4, a well-known antiinflammatory cytokine, facilitates microglia- and macrophage-mediated hematoma resolution and improves long-term functional recovery in two different mouse models of intracerebral hemorrhage. Mechanistically, IL-4 activates a signaling cascade involving signal transducer and activator of transcription 6 and IL-1 receptor-like 1, thereby enhancing the phagocytotic capability of microglia and macrophages to remove red blood cells from intracerebral hematomata. Our in vitro and in vivo preclinical studies support the view that IL-4 treatment has the therapeutic potential to promote hematoma resolution and functional restoration in hemorrhagic stroke victims.