bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence‐informed Approach to Setting Standards: A Discussion on the Research Strategies of AASB and AUASB
Authors: Garg Mukesh , Peach Kris , Simnett Roger 
Published: July 2020

AbstractThis paper provides a commentary on the approach used by the Australian Accounting Standards Board (AASB) and the Auditing and Assurance Standards Board (AUASB) in setting standards which are consistent with their vision and mission to contribute to stakeholder confidence in the Australian economy, including its capital markets, and in external reporting. The objective of the paper is to inform a wide range of stakeholders including academics, assurance practitioners, investors, preparers of financial reports and regulators on how the two standardsetters use a robust and transparent evidence‐informed approach to setting standards and guidance in Australia. The evidence is also applied to influence international standardsetters and to enhance key international relationships by demonstrating thought leadership. The AASB's and the AUASB's standard‐setting process involves robust consultation with stakeholders and is guided by the evidence‐informed standard‐setting frameworks of the two boards. The paper also provides insight into how evidence is gathered and implemented by the standardsetters and discusses the process for building and maintaining strong relationships with the research community. The collaborative effort not only supports researchers in contributing to the academic literature but also for them to have a regulatory impact by informing the financial reporting and assurance standard‐setting process.
Facial expressions when learning with a Queer History App: Application of the Control Value Theory of Achievement Emotions
Authors: Ahn Byunghoon “Tony” , Harley Jason M. 
Published: July 2020

AbstractLearning analytics (LA) incorporates analyzing cognitive, social and emotional processes in learning scenarios to make informed decisions regarding instructional design and delivery. Research has highlighted important roles that emotions play in learning. We have extended this field of research by exploring the role of emotions in a relatively uncommon learning scenario: learning about queer history with a multimedia mobile app. Specifically, we used an automatic facial recognition software (FaceReader 7) to measure learners’ discrete emotions and a counter‐balanced multiple‐choice quiz to assess learning. We also used an eye tracker (EyeLink 1000) to identify the emotions learners experienced while they read specific content, as opposed to the emotions they experienced over the course of the entire learning session. A total of 33 out of 57 of the learners’ data were eligible to be analyzed. Results revealed that learners expressed more negative‐activating emotions (ie, anger, anxiety) and negative‐deactivating emotions (ie, sadness) than positive‐activating emotions (ie, happiness). Learners with an angry emotion profile had the highest learning gains. The importance of examining typically undesirable emotions in learning, such as anger, is discussed using the control‐value theory of achievement emotions. Further, this study describes a multimodal methodology to integrate behavioral trace data into learning analytics research.
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine‐inspired P‐glycoprotein inhibitors
Authors: Syed Safiulla Basha , Lin Shu‐Yu , Arya Hemant , Fu I‐Hsuan , Yeh Teng‐Kuang , Charles Mariasoosai Ramya Chandar , Periyasamy Latha , Hsieh Hsing‐Pang , Coumar Mohane Selvaraj 
Published: July 2020

AbstractP‐glycoprotein (P‐gp)/MDR‐1 plays a major role in the development of multidrug resistance (MDR) by pumping the chemotherapeutic drugs out of the cancer cells and reducing their efficacy. A number of P‐gp inhibitors were reported to reverse the MDR when co‐administered with chemotherapeutic drugs. Unfortunately, none has approved for clinical use due to toxicity issues. Some of the P‐gp inhibitors tested in the clinics are reported to have cross‐reactivity with CYP450 drug‐metabolizing enzymes, resulting in unpredictable pharmacokinetics and toxicity of co‐administered chemotherapeutic drugs. In this study, two piperine analogs (3 and 4) having lower cross‐reactivity with CYP3A4 drug‐metabolizing enzyme are identified as P‐glycoprotein (P‐gp) inhibitors through computational design, followed by synthesis and testing in MDR cancer cell lines over‐expressing P‐gp (KB ChR 8–5, SW480‐VCR, and HCT‐15). Both the analogs significantly increased the vincristine efficacy in MDR cancer cell lines at low micromole concentrations. Specifically, 3 caused complete reversal of vincristine resistance in KB ChR 8–5 cells and found to act as competitive inhibitor of P‐gp as well as potentiated the vincristine‐induced NF‐KB‐mediated apoptosis. Therefore, 3 ((2E,4E)‐1‐(6,7‐dimethoxy‐3,4‐dihydroisoquinolin‐2(1H)‐yl)‐5‐(4‐hydroxy‐3‐methoxyphenyl)penta‐2,4‐dien‐1‐one) can serve as a potential P‐gp inhibitor for in vivo investigations, to reverse multidrug resistance in cancer.
Chromosome microarray analysis should be offered to all invasive prenatal diagnostic testing following a normal rapid aneuploidy test result
Authors: Rodriguez‐Revenga Laia , Madrigal Irene , Borrell Antoni , Martinez Josep M. , Sabria Joan , Martin Lourdes , Jimenez Wladimiro , Mira Aurea , Badenas Celia , Milà Montserrat 
Published: July 2020

AbstractChromosomal microarray analysis (CMA) has now replaced karyotyping in the analysis of prenatal cases with a fetal structural anomaly, whereas in those pregnancies undergoing invasive prenatal diagnosis with a normal fetal ultrasound, conventional karyotyping is still performed. The aims of this study were to establish the diagnostic yield of CMA in prenatal diagnosis, and to provide new data that might contribute to reconsider current practices. We reviewed 2905 prenatal samples with a normal rapid aneuploidy detection test referred for evaluation by CMA testing. Our study revealed pathogenic and reported susceptibility copy number variants associated with syndromic disorders in 4.8% (n = 138/2905) of cases, being 2.8% (n = 81/2905) the estimated added diagnostic value of CMA over karyotyping. Clinically significant CMA abnormality was detected in 5.4% (107/1975) of the fetuses with ultrasound anomalies and in 1.4% (5/345) of those considered as low‐risk pregnancies. Our series shows that in prenatal samples, CMA increases 2‐fold the diagnostic yield achieved by conventional karyotyping.
The Evolution of India's Industrial Labour Share and its Correlates
Authors: Jayadev Arjun , Narayan Amay 
Published: July 2020

ABSTRACTThere has been substantial recent interest in the decline of labour shares across many countries. For the most part, attention has been focused on developed countries. This article examines the evolution of India's labour share in its formal industrial sector from 1983 to 2016. Using two datasets corresponding to sectoral aggregate data and plant‐level data respectively, the authors document a secular decline in the labour share across all sectors from 1983, with a stabilization at very low levels (around 8 to 10 per cent) starting around 2007. The plant‐level data are used to identify correlates that illuminate reasons for the overall decline in the labour share. The authors find strong evidence to support multiple causes, including increased capital intensity, greater informalization, greater privatization, and productivity increases in larger firms; they therefore suggest that the declines in labour share experienced are due to a composite set of factors. Conversely, other potential explanations (such as regional variation in the labour share) have less explanatory power.
External Financial Liberalization and Macroeconomic Performance in Emerging Countries: An Empirical Evaluation of the Brazilian Case
Authors: Cunha André Moreira , Prates Daniela Magalhães , da Silva Pedro Perfeito 
Published: July 2020

ABSTRACTThis article evaluates the effects of external financial liberalization on Brazilian macroeconomic performance from 1995 to 2016. Its main contributions are to assess the influence of the global financial cycle on the level of external financial liberalization and to analyse the short‐ and long‐run macroeconomic effects of such liberalization on the performance of a peripheral economy in the global currency hierarchy. Methodologically, the article employs the Markov‐Switching Vector Autoregressive and Vector Error Correction models. The results show that the global financial cycle directly affects cross‐border financial flows and frames the impact of external financial liberalization on the macroeconomic performance. The article concludes that external financial liberalization has negative macroeconomic effects in the short run and generates a trade‐off between stability and growth in the long run.
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes
Authors: Carr A. L. J. , Perry D. J. , Lynam A. L. , Chamala S. , Flaxman C. S. , Sharp S. A. , Ferrat L. A. , Jones A. G. , Beery M. L. , Jacobsen L. M. , Wasserfall C. H. , Campbell‐Thompson M. L. , Kusmartseva I. , Posgai A. , Schatz D. A. , Atkinson M. A. , Brusko T. M. , Richardson S. J. , Shields B. M. , Oram R. A. 
Published: July 2020

AbstractAimsMisclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed that can aid classification, but they have not been validated using pancreatic pathology. We evaluated a clinical diagnostic model against histologically defined type 1 diabetes.MethodsWe classified cases from the Network for Pancreatic Organ donors with Diabetes (nPOD) biobank as type 1 (n = 111) or non‐type 1 (n = 42) diabetes using histopathology. Type 1 diabetes was defined by lobular loss of insulin‐containing islets along with multiple insulin‐deficient islets. We assessed the discriminative performance of previously described type 1 diabetes diagnostic models, based on clinical features (age at diagnosis, BMI) and biomarker data [autoantibodies, type 1 diabetes genetic risk score (T1D‐GRS)], and singular features for identifying type 1 diabetes by the area under the curve of the receiver operator characteristic (AUC‐ROC).ResultsDiagnostic models validated well against histologically defined type 1 diabetes. The model combining clinical features, islet autoantibodies and T1D‐GRS was strongly discriminative of type 1 diabetes, and performed better than clinical features alone (AUC‐ROC 0.97 vs. 0.95; P = 0.03). Histological classification of type 1 diabetes was concordant with serum C‐peptide [median < 17 pmol/l (limit of detection) vs. 1037 pmol/l in non‐type 1 diabetes; P < 0.0001].ConclusionsOur study provides robust histological evidence that a clinical diagnostic model, combining clinical features and biomarkers, could improve diabetes classification. Our study also provides reassurance that a C‐peptide‐based definition of type 1 diabetes is an appropriate surrogate outcome that can be used in large clinical studies where histological definition is impossible.Parts of this study were presented in abstract form at the Network for Pancreatic Organ Donors Conference, Florida, USA, 19–22 February 2019 and Diabetes UK Professional Conference, Liverpool, UK, 6–8 March 2019.
The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes
Authors: Yang J.‐F. , Xiong X.‐F. , Xiao Y. , Wei L. , Li L. , Yang M. , Han Y.‐C. , Zhao H. , Li C.‐R. , Jiang N. , Xiong S. , Zeng L.‐F. , Zhou Z.‐G. , Liu S.‐P. , Wang N.‐S. , Fan Y. , Sun L. 
Published: July 2020

AbstractAimsTo examine the association between 24 literature‐based single nucleotide polymorphisms and diabetic kidney disease in Chinese people with type 2 diabetes.Methods and resultsTwenty‐four candidate diabetic kidney disease‐susceptible single nucleotide polymorphisms were genotyped in 208 participants with type 2 diabetes and diabetic kidney disease and 200 participants with type 2 diabetes without diabetic kidney disease (case and control groups, respectively), together with 206 healthy participants using MassARRAY. Rs11643718 in the SLC12A3 gene was associated with diabetic kidney disease in the recessive model after adjusting for confounding factors, such as age and gender (adjusted odds ratio 2.056, 95% CI 1.120–3.776; P = 0.020). Meta‐analyses further confirmed the association (P = 0.002). In addition, participants with the GG genotype had worse renal function and more albuminuria than those with the AA+AG genotype (P < 0.05). Renal section immunohistochemistry was conducted in participants with type 2 diabetes, diabetic kidney disease and AA+AG or GG genotypes and in participants with glomerular minor lesions. Together with data from the Nephroseq database, it was shown that the abundance of SLC12A3 was reduced in patients with the GG genotype, while elevated expression of SLC12A3 was associated with better renal function. In addition, rs10951509 and rs1345365 in ELMO1, which were determined to be in high linkage disequilibrium by SHEsis software, were also associated with diabetic kidney disease (adjusted P = 0.010 and 0.015, respectively).ConclusionsThe G allele and GG genotype of SLC12A3 rs11643718 are associated with the development of diabetic kidney disease in a Chinese population with type 2 diabetes.
Potato flour as a functional ingredient in bread: evaluation of bread quality and starch characteristics
Authors: Whitney Kristin , Simsek Senay 
Published: July 2020

SummaryPotatoes have been added to bread for improvement of texture and moisture retention. The functional quality and starch digestibility in bread containing 5%, 10% or 15% potato flour were evaluated. Farinograph absorption of wheat and potato flour blends ranged from 59.0% to 77.7%. Bread with potato flour had significantly (P < 0.05) lower bread firmness during storage. There was a significant (P < 0.05) decrease in starch molecular weight as the level of potato flour increased. Inclusion of potato flour in these breads significantly (P < 0.05) increased the level of resistant starch (RS), while significantly (P < 0.05) decreasing the estimated glycemic index (eGI). Bread with no potato flour had 5.2% RS and an eGI of 95, while the bread with 15% potato flour had 11.3% RS and an eGI of 87. Overall, the addition of potato flour may reduce dough strength and loaf volume, but it reduced staling and increased resistant starch content of the bread.
Boiled yam end‐user preferences and implications for trait evaluation
Authors: Honfozo Laurenda , Adinsi Laurent , Bouniol Alexandre , Adetonah Sounkoura , Forsythe Lora , Kleih Ulrich , Hounhouigan Joseph D. , Fliedel Geneviève , Akissoe Noël H. 
Published: July 2020

SummaryThis study aimed to establish the quality characteristics of raw and boiled yam by involving stakeholders along the food chain using a methodology that includes a state of knowledge review, focus group discussion and individual interviews, participatory processing diagnosis with processors and consumer testing. Predictive characteristics of yam for producing a high‐ and low‐quality boiled yam were related to morphological or physicochemical characteristics: peeled yam discoloration and mucilage content being negatively appreciated while the ease of peeling, viscous state of cooking water and the ease of breaking yam into pieces positively valued. High‐quality boiled yam should be white or yellowish, sticky to the fingers, nonfibrous, easy to chew, crumbly/friable, with a sweet taste and a good smell. The overall liking of boiled yam is greatly penalised by a too dark colour, hard to the touch, no sweet taste and no friability while eating.
Benefits of robotic cystectomy compared with open cystectomy in an Enhanced Recovery After Surgery program: A propensity‐matched analysis
Authors: Tan Yu Guang , Allen John Carson , Tay Kae Jack , Huang Hong Hong , Lee Lui Shiong 
Published: July 2020

ObjectivesTo compare the perioperative and oncological outcomes between robot‐assisted radical cystectomy with intracorporeal urinary diversion versus open cystectomy for bladder cancer in a contemporary Enhanced Recovery After Surgery cohort.MethodsAll consecutive patients who underwent radical cystectomy and managed under an Enhanced Recovery After Surgery protocol, from December 2013 to October 2018, were reviewed. Propensity score adjustment was carried out to reduce biases attributable to covariate imbalances.ResultsThere were 19 robot‐assisted radical cystectomy with intracorporeal urinary diversion and 21 open cystectomy patients. The robot‐assisted radical cystectomy with intracorporeal urinary diversion cohort was associated with lower estimated blood loss (397 vs 787 mL, P = 0.05), with a trend toward shorter duration of ileus and postoperative opioid administration. These benefits were apparent, despite a longer operative time (581 vs 446 mins, P = 0.03), a higher proportion of orthotopic bladder reconstruction (26.3 vs 9.5%, P = 0.08), a more prevalent use of neoadjuvant chemotherapy and a higher number of salvage cystectomies for the robot‐assisted radical cystectomy with intracorporeal urinary diversion group. Comparable perioperative complications and length of hospital stay were observed. The pathological and intermediate oncological outcomes were similar in both groups (locally advanced disease: 52.6 vs 47.6%, P = 0.85; lymph node yield: 29 vs 34, P = 0.23). The mean recurrence‐free survival and overall survival in the robot‐assisted radical cystectomy with intracorporeal urinary diversion group was 37.5 and 43.0 months, respectively, compared with 21.4 (P = 0.09) and 35.5 (P = 0.14) months, respectively, in open cystectomy.ConclusionRobot‐assisted radical cystectomy with intracorporeal urinary diversion has perioperative benefits of lower estimated blood loss, with a trend toward faster bowel recovery and a shorter duration of opioid analgesia when compared with open cystectomy. Robot‐assisted radical cystectomy with intracorporeal urinary diversion also achieves similar intermediate‐term oncological and survival outcomes.
MHC class I transactivator NLRC5 in host immunity, cancer and beyond
Authors: Cho Steven X. , Vijayan Saptha , Yoo Ji‐Seung , Watanabe Toshiyuki , Ouda Ryota , An Ning , Kobayashi Koichi S. 
Published: July 2020

SummaryThe presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide‐binding domain and leucine‐rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class‐I‐related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5‐dependent MHC class I expression.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S‐sulfhydration
Authors: Lu Fangping , Lu Baoling , Zhang Linxue , Wen JingChen , Wang Mengyi , Zhang Shiwu , Li Qianzhu , Shu Feng , Sun Yu , Liu Ning , Peng Shuo , Zhao Yajun , Dong Shiyun , Zhao Dechao , Lu Fanghao , Zhang Weihua 
Published: July 2020

AbstractMuscle atrophy occurs in many pathological states, including cancer, diabetes and sepsis, whose results primarily from accelerated protein degradation and activation of the ubiquitin‐proteasome pathway. Expression of Muscle RING finger 1 (MuRF1), an E3 ubiquitin ligase, was increased to induce the loss of muscle mass in diabetic condition. However, hydrogen sulphide (H2S) plays a crucial role in the variety of physiological functions, including antihypertension, antiproliferation and antioxidant. In this study, db/db mice and C2C12 myoblasts treated by high glucose and palmitate and oleate were chose as animal and cellular models. We explored how exogenous H2S attenuated the degradation of skeletal muscle via the modification of MuRF1 S‐sulfhydration in db/db mice. Our results show cystathionine‐r‐lyase expression, and H2S level in skeletal muscle of db/db mice was reduced. Simultaneously, exogenous H2S could alleviate ROS production and reverse expression of ER stress protein markers. Exogenous H2S could decrease the ubiquitination level of MYOM1 and MYH4 in db/db mice. In addition, exogenous H2S reduced the interaction between MuRF1 with MYOM1 and MYH4 via MuRF1 S‐sulfhydration. Based on these results, we establish that H2S prevented the degradation of skeletal muscle via MuRF1 S‐sulfhydration at the site of Cys44 in db/db mice.
Migration patterns of a potamodromous piscivore, asp (Leuciscus aspius), in a river–lake system
Authors: Kärgenberg Einar , Økland Finn , Thalfeldt Mart , Thorstad Eva B. , Sandlund Odd Terje , Tambets Meelis 
Published: July 2020

AbstractPotamodromous fishes require safe migration routes between spawning, feeding and wintering habitats to complete their life cycle. As knowledge on asp migrations is restricted, this work investigated the movements of adult asp tagged with acoustic transmitters for 3 years in the large Peipsi‐Emajõgi‐Võrtsjärv lake–river system, Estonia, which is free of migration barriers. Asp showed complex migration patterns, moving between and within different waterbodies (lakes, river, tributaries) in all seasons, but with a tendency to repeat habitat use patterns between years. Lakes were mainly used for feeding during spring and summer (after spawning 65% of the fish migrated to Lake Peipsi), and more so by large fish. The majority (80–96%) of the fish spent the winter in the rivers, mostly close to their subsequent spawning area. Spawning areas were in swift‐flowing waters in tributaries and the main river. The results indicate that asp may benefit from an extensive and diverse complex of habitats, and any migration barrier during any season may restrict the natural habitat use by asp. Maintenance and restoration of habitat heterogeneity and connectivity is critical to protect behaviourally diverse fish populations and increase resilience in rivers negatively impacted by various human activities.