bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation
Authors: Kizhuveetil Uma , Omer Sonal , Karunagaran D. , Suraishkumar G. K. 
Published: January 2020

AbstractRhythms in the pseudo-steady state (PSS) levels of reactive species (RS), particularly superoxide and hydroxyl radicals, exist in cancer cells. The RS rhythm characteristics, particularly frequency and amplitude, are entrained (reset) by the anticancer compounds/drugs. In this work, we show for the first time that the phase of the RS rhythm at which the drug is added is significantly important in determining the cytotoxicity of anticancer compounds/drugs such as menadione and curcumin, in two different cancer cell lines. Curcumin, the more effective of the two drugs (IC50 = 15 µM, SiHa; 6 µM, HCT116) induced reset of superoxide and hydroxyl rhythms from 15.4 h to 9 h, and 25 h to 11 h respectively, as well as caused increases in these radical levels. However, menadione (IC50 = 20 µM, SiHa; 17 µM, HCT116) affected only the superoxide levels. Drug treatment at different time points/phase of the RS rhythm resulted in a maximum of 27% increase in cytotoxicity, which is significant. Further, we report for the first time, an unexpected absence of a correlation between the intracellular PSS RS and antioxidant levels; thus, the practice of using antioxidant enzyme levels as surrogate markers of intracellular oxidative stress levels may need a re-consideration. Therefore, the RS rhythm could be a fundamental/generic target to manipulate for improved cancer therapy.
Somatic Symptoms in the German General Population from 1975 to 2013
Authors: Beutel Manfred E. , Klein Eva M. , Henning Michaela , Werner Antonia M. , Burghardt Juliane , Tibubos Ana Nanette , Schmutzer Gabriele , Brähler Elmar 
Published: January 2020

AbstractThe study determines how burden and patterns of somatic symptom reporting developed over almost four decades in the general German population. Additionally, we studied how socio-demographic factors affected the degree of somatic symptoms. Population-based samples representative for West Germany between 18 and 60 years of age were analyzed comparing three cross-sectional samples of 1975 (N = 1601), 1994 (N = 1416), and 2013 (N = 1290) by conducting a three-way analysis of variance (sex, age, survey). The prevalence rates for somatic symptoms in men and women were lower in the more recent surveys; this affected women most strongly. Exhaustion and musculoskeletal complaints remained leading symptoms (affecting 25%, resp. 11% of the men and 30%, resp. 19% of the women). There was a slight increase in women’s prevalence of exhaustion from 1994 (15%) to 2013 (19%). As determined by stepwise multiple regression, somatic symptoms were consistently associated with female sex and higher age. In the 2013 survey, education became an additional negative predictor of somatic symptom load, while the impact of age and sex on somatic symptoms reporting decreased. Somatic symptoms remain a major burden in the general population. Findings are interpreted with regard to improved living and health care conditions, different cohort experiences, and more public health information.
Rapid Sensing of Key Quality Components in Black Tea Fermentation Using Electrical Characteristics Coupled to Variables Selection Algorithms
Authors: Dong Chunwang , An Ting , Zhu Hongkai , Wang Jinjin , Hu Bin , Jiang Yongwen , Yang Yanqin , Li Jia 
Published: January 2020

AbstractBased on the electrical characteristic detection technology, the quantitative prediction models of sensory score and physical and chemical quality Index (theaflavins, thearubigins, and theabrownins) were established by using the fermented products of Congou black tea as the research object. The variation law of electrical parameters during the process of fermentation and the effects of different standardized pretreatment methods and variable optimization methods on the models were discussed. The results showed that the electrical parameters vary regularly with the test frequency and fermentation time, and the substances that hinder the charge transfer increase gradually during the fermentation process. The Zero-mean normalization (Zscore) preprocessing method had the best noise reduction effect, and the prediction set correlation coefficient (Rp) value of the original data could be increased from 0.172 to 0.842. The mixed variable optimization method (MCUVE-CARS) of Monte Carlo uninformed variable elimination (MC UVE) and competitive adaptive reweighted sampling (CARS) was proved that the characteristic electrical parameters were the loss factor (D) and reactance (X) of the low range. Based on the characteristic variables screened by MCUVE-CARS, the quantitative prediction models for each fermentation quality indicator were established. The Rp values of the sensory score, theaflavin, thearubigin and theabrownins of the predicted models were 0.924, 0.811, 0.85 and 0.938 respectively. The relative percent deviation (RPD) values of the sensory score, theaflavins, thearubigins and theabrownins of the predicted models were 2.593, 1.517, 1,851 and 2.920 respectively, and it showed that these models have good performance and could realize quantitative characterization of key fermentation quality indexes.
The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes
Authors: Zhang Yong , Yang He , Turra David , Zhou Shiguo , Ayhan Dilay Hazal , DeIulio Gregory A. , Guo Li , Broz Karen , Wiederhold Nathan , Coleman Jeffrey J. , Donnell Kerry O’ , Youngster Ilan , McAdam Alexander J. , Savinov Sergey , Shea Terrance , Young Sarah , Zeng Qiandong , Rep Martijn , Pearlman Eric , Schwartz David C. , Di Pietro Antonio , Kistler H. Corby , Ma Li-Jun 
Published: January 2020

AbstractFusarium oxysporum is a cross-kingdom fungal pathogen that infects plants and humans. Horizontally transferred lineage-specific (LS) chromosomes were reported to determine host-specific pathogenicity among phytopathogenic F. oxysporum. However, the existence and functional importance of LS chromosomes among human pathogenic isolates are unknown. Here we report four unique LS chromosomes in a human pathogenic strain NRRL 32931, isolated from a leukemia patient. These LS chromosomes were devoid of housekeeping genes, but were significantly enriched in genes encoding metal ion transporters and cation transporters. Homologs of NRRL 32931 LS genes, including a homolog of ceruloplasmin and the genes that contribute to the expansion of the alkaline pH-responsive transcription factor PacC/Rim1p, were also present in the genome of NRRL 47514, a strain associated with Fusarium keratitis outbreak. This study provides the first evidence, to our knowledge, for genomic compartmentalization in two human pathogenic fungal genomes and suggests an important role of LS chromosomes in niche adaptation.
Words-in-Noise Test Performance in Young Adults Perinatally HIV Infected and Exposed, Uninfected
Authors: Torre Peter , Russell Jonathan S. , Smith Renee , Hoffman Howard J. , Lee Sonia , Williams Paige L. , Yao Tzy-Jyun ,   for the Pediatric HIV/AIDS Cohort Study (PHACS)
Published: January 2020

PurposeThe purpose of this study was to compare Words-in-Noise (WIN) data between young adults with perinatal HIV (PHIV) infection and those with PHIV exposure but uninfected (PHEU) and to evaluate associations between antiretroviral therapy (ART) exposures and WIN data.MethodThe WIN test and cognitive function were assessed in participants of the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol Up. Impaired WIN (IWIN) performance was defined as a signal-to-babble ratio of > +10 dB. Cognitive function was determined based on fluid cognition composite scores (FCCSs) and crystallized cognition composite scores, and < 70 was considered a fluid or crystallized cognitive impairment. Log binomial models were used to calculate the relative risks of IWIN between PHIV and PHEU.ResultsPHIV (n= 334) and PHEU (n= 52) participants had similar WIN thresholds and IWIN percentages. For young adults with FCCS ≥ 70, participants with PHIV were less likely to have IWIN for the better ear and worse ear as compared to participants with PHEU. For young adults with FCCS < 70, there was no association between HIV status and risk of IWIN for the better ear or worse ear. For those adults with crystallized cognition composite score of ≥ 70, young adults with PHIV were less likely to have IWIN for the better ear than young adults with PHEU; there was no association between HIV status and IWIN for the worse ear. For young adults with PHIV without a Centers for Disease Control and Prevention Class C diagnosis, a longer combination ART duration was associated with a higher risk of IWIN for the better ear.ConclusionsFor those without cognitive impairment, young adults with PHEU had poorer WIN thresholds than those young adults with PHIV. In young adults with PHIV who had no prior Centers for Disease Control and Prevention Class C diagnosis, a longer combination ART duration was associated with IWIN only in the better ear.
The Acquisition of Productive Plural Morphology by Children With Hearing Loss
Authors: Davies Benjamin , Xu Rattanasone Nan , Davis Aleisha , Demuth Katherine 
Published: January 2020

Purpose

Normal-hearing (NH) children acquire plural morphemes at different rates, with the segmental allomorphs /–s, –z/ (e.g.,
cat-s
) being acquired before the syllabic allomorph /–əz/ (e.g.,
bus-es
). Children with hearing loss (HL) have been reported to show delays in the production of plural morphology, raising the possibility that this might be due to challenges acquiring different types of lexical/morphological representations. This study therefore examined the comprehension of plural morphology by 3- to 7-year-olds with HL and compared this with performance by their NH peers. We also investigated comprehension as a function of wearing hearing aids (HAs) versus cochlear implants (CIs).

Method

Participants included 129 NH children aged 3–5 years and 25 children with HL aged 3–7 years (13 with HAs, 12 with CIs). All participated in a novel word two-alternative forced-choice task presented on an iPad. The task tested comprehension of the segmental (e.g.,
teps, mubz
) and syllabic (e.g.,
kosses
) plural, as well as their singular counterparts (e.g.,
tep, mub, koss
).

Results
While the children with NH were above chance for all conditions, those with HL performed at chance. As a group, the performance of the children with HL did not improve with age. However, results suggest possible differences between children with HAs and those with CIs, where those with HAs appeared to be in the process of developing representations of consonant–vowel–consonant singulars.

Conclusions
Results suggest that preschoolers with HL do not yet have a robust representation of plural morphology for words they have not heard before. However, those with HAs are beginning to access the singular/plural system as they get older.
Voice Characteristics of Female College Athletes: A Pilot Study
Authors: Cox Steven R. , Milillo Stephanie , Maman Zahra Sedighi 
Published: January 2020

Purpose
The purpose of this study was to identify changes in NCAA Division II female athletes' objective and subjective voice characteristics before, during, and after a regular volleyball season.

Method
Acoustic, aerodynamic, and Voice Handicap Index-10 data were collected from five female volleyball athletes at three timepoints: preseason, midseason, and postseason.

Results
Individual data suggest increases in objective and subjective voice characteristics at midseason, but many values returned to typical limits at postseason. Increases observed in acoustic, aerodynamic, and Voice Handicap Index-10 data for the volleyball team captain remained elevated at midseason and postseason.

Conclusions
Female volleyball players are a group of voice users who are required to communicate in the presence of background noise while engaging in varying levels of physical effort. As a result, they may experience negative changes to objective and/or subjective voice characteristics during a regular season. The present data, concerning changes in female volleyball athletes' voice characteristics, need to be confirmed by studies with a larger number of participants.
Computational support on the development of nuclear heating calorimeter detector design
Authors: Ambrožič Klemen , Fourmentel Damien , Carcreff Hubert , Radulović Vladimir , Snoj Luka 
Published: January 2020

Heating due to energy deposition of intense ionizing radiation in samples and structural materials of nuclear reactors poses severe limitations in terms of cooling requirements for safe reactor operation, especially in high neutron and gamma flux environments of material testing fission reactors (MTRs) and novel fusion devices. A bilateral CEA-JSI research project was launched in 2018 with the objective to measure the gamma heating rates in standard reactor-related materials (graphite, aluminium, stainless steel and tungsten) as well as fusionrelevant materials (low-activation steel Eurofer-97 and Nb3Sn superconductor) in the JSI TRIGA reactor my means of gamma calorimeters. The calorimeter design will be based on the the CALMOS-2 calorimeter developed at the CEA and used to perform gamma heating measurements in the OSIRIS MTR in Saclay.
In order to optimize the detector response inside the JSI TRIGA reactor field and not to perturb the measurement field, a detailed computational analysis was performed in terms of energy deposition assessment and measurement field perturbation using the MCNP v6.1 code, and in terms of heat transfer using the COMSOL Multiphysics code.
The abovementioned activities enabled us to finalize the detector design with the experimental campaign planned for the end of year 2019.
Trinocular views of register
Authors: Matthiessen Christian M. I. M. 
Published: January 2020

Abstract
Michael Halliday’s argument for the value of ‘trinocular vision’ in linguistic research has particular relevance
to the observation, exploration and description of register. Taking each semiotic dimension relevant to the characterisation of
register by turn, I begin by discussing Halliday’s proposition. I then proceed, using the metaphor of cartography, to examine
register variation via the intersection of three semiotic dimensions: stratification, instantiation and metafunction. I discuss
how such examinations enable us to create description maps of register variation. From this basis, I discuss a long-term programme
of systematically producing descriptive maps of registers, which I and colleagues have begun. Finally, I suggest that by using
such maps we can better understand such important phenomena as aggregates of registers and personal register repertoires.
Is there a role for prosody within register studies
Authors: O’Grady Gerard 
Published: January 2020

Abstract
This article examines whether the incorporation of prosody within register studies can lead to a richer description of what speakers can mean in a specific environment. In order to situate how prosody resets the probabilities of contextual variables, a number of texts are examined and it is argued that prosodic systems at and above the rank of tone group are meaningful and situated on the content plane. The article concludes by suggesting some redrawing of the standard SFL stratification model by arguing that the view that meaning redounds with wording which in turn redounds with sounding needs some revision to incorporate the higher units of the phonological rank scale being situated on the content plane.
On the interaction between register variation and regional varieties in English
Authors: Neumann Stella 
Published: January 2020

AbstractThis paper examines the extent to which regional varieties of English influence register variation. Register is a key concept in systemic functional linguistics (SFL), whereas regional variation is rarely studied in this framework. However, languages like Chinese, Spanish and English are used in more than one region and such more complex language situations raise the question of whether registers are used consistently throughout. In this study, texts from three varieties represented in the International Corpus of English are analysed for frequencies of 41 lexico-grammatical features and subjected to exploratory multivariate analysis. The analysis shows that, while there are clear indications of register patterns irrespective of varieties, variety appears to override register in some cases. Variety therefore needs to be accounted for in language theory in addition to the language system and registers as subsystems.
Ways of meaning
Authors: Karimi Neda , Moore Alison Rotha , Lukin Annabelle 
Published: January 2020

Abstract
This paper explores one aspect of the operationalisation of a patient-centred ideology of care by examining an
oncologist’s answers to questions asked by her patient and his companion during a palliative oncology consultation and comparing her answers
to the markedly different answers of another oncologist. Halliday’s concept of register and Hasan’s semantic networks are used to examine
the oncologists’ answers. Patients’ questions create the semiotic environment for clinicians to provide the information patients need for
informed decision-making – an important aspect of patient-centredness. The answers clinicians provide construe their position towards this
ideology of care. Findings suggest that one way patient-centredness can be operationalised, at the level of semantics, is through providing
elaborated answers that explicitly display the reasoning employed by the oncologist.
Nominalisation and genre in early discourses on electricity
Authors: Cummings Michael 
Published: January 2020

Abstract
Halliday proposes that a key role in the language of science is played by compacting nominalisation, a strategy by
which qualities and processes in one phase of a discourse are then nominalised in a following phase to facilitate the flow of
argument. Compacting nominalisation is very characteristic of Priestley’s
1767 The history and present state of electricity. However, another book of the same era and field,
Franklin’s 1751–1754 New experiments and observations on electricity, employs little of this strategy. One explanation lies in genre
differences. Franklin’s book and accounts of electrical experiments into the Philosophical transactions of the same
era are both generically similar to and different from Priestley’s book, quite beyond the issue of compacting nominalisation. Generic
similarities and differences are here demonstrated in terms of register values.
Practices of clause-combining
Authors: Günthner Susanne 
Published: January 2020

Traditionally, conditional
wenn-clauses in German are
treated as subordinate clauses, either preceding or
following their matrix clauses. My data – based on
naturally occurring German talk-in-interaction from
various settings – show that participants in
everyday interactions use various types of
(pre-positioned) wenn-constructions
as resources to accomplish social activities. These
constructions not only blur the boundaries between
subordinated and main clauses, but also reveal a
wide range of in-between
wenn-constructions ranging from
tightly integrated to loosely integrated, from
non-integrated to free-standing.
The empirically based analysis, furthermore,
shows that practices of clause-combining turn out to
be closely connected to the temporal unfolding of
talk-in-interaction, and thus to issues of
projection, retractive expansions as well as the
ongoing accomplishment of social action.
Grammatical coordination of embodied action
Authors: Keevallik Leelo 
Published: January 2020

Abstract
This paper looks at the Estonian
coordinating conjunction ja ‘and’
in video-recorded Pilates classes, focusing on the
instructors’ practical problem of making the
students perform proper movement sequences. It shows
how grammatical coordination emerges within a
multimodal activity in which the instructor’s talk
both directs and responds to student performance. As
opposed to the frequent juxtaposition of clauses
without connectors, explicit coordination with
ja is used for the overall
structuring of the class as well as the temporal
extension of talk to achieve synchronicity of vocal
and embodied behavior. In contrast to formal
theories that consider grammar as a device for
coherent expression of pre-planned propositions,
this study argues that grammatical structure emerges
as part of practical action across participants and
modalities.
Atypical sign language development
Authors: Marshall Chloë , Rowley Katherine , Atkinson Joanna , Denmark Tanya , Hoskins Joanna , Sieratzki Jechil 
Published: January 2020

Abstract
A major theme in Bencie Woll’s research has been what the study of sign language and atypical signers who have neurological differences can teach us about language and cognition more generally. In this chapter, we focus on the growing literature relating to atypical sign language development, with an emphasis on Bencie’s pioneering work in this field. We show that by studying atypical users of language we gain insights into language and cognitive processes that would not be obtained by studying typical users, or by limiting research to spoken languages. We review developmental research of individuals and groups with Landau-Kleffner Syndrome, Williams Syndrome, Autism Spectrum Disorder and Specific Language Impairment. Finally, we consider issues relating to intervention.
Return on Investment and Value Research in Neuropsychology: A Call to Arms†
Authors: Glen Tannahill , Hostetter Gayle , Roebuck-Spencer Tresa M , Garmoe William S , Scott James G , Hilsabeck Robin C , Arnett Peter , Espe-Pfeifer Patricia 
Published: January 2020

Abstract
There is substantial empirical evidence to support the clinical value of neuropsychological evaluation and the incremental value of neuropsychological assessment, suggesting such evaluation is beneficial in the prediction and management of clinical outcomes. However, in the cost-conscious and evolving era of healthcare reform, neuropsychologists must also establish the economic value, or return on investment, of their services. There is already a modest body of literature that demonstrates the economic benefits of neuropsychological evaluation, which is reviewed in the current paper. Neuropsychologists will need to be able to communicate, and develop evidence of, economic value of their services; thus, this paper also discusses common concepts, terms, and models used in healthcare valuation studies. Finally, neuropsychologists are urged to incorporate these financial concepts in their clinical practice and research.
I—The Presidential Address
Authors: Steward Helen 
Published: January 2020

Abstract
This paper considers the analogies and disanalogies between a certain sort of argument designed to oppose scepticism about free will (in the sense of genuine agency) and a certain sort of argument designed to oppose scepticism about the external world. In the case of free will, I offer the ancient Lazy Argument and an argument of my own, which I call the Agency Argument, as examples of the relevant genre; and in the case of the external world, I consider Moore’s alleged proof of an external world. I draw attention to analogies and disanalogies between the arguments offered in each case in order to suggest that although the Agency Argument shares with its Moorean relative the unfortunate property of being dialectically ineffective against some of those it is mainly hoping to convince, it will not be dialectically ineffective against all of them. It is also argued that the Agency Argument is less vulnerable than Moore’s proof to worries about its justificatory structure.