bluuebunny/crossref_metadata_2025_split huggingface dataset:
It's geology time: Redesigning the Lapworth Museum of Geology
Authors: Burke Verity 
Published: April 2020

AbstractIn 2014, the Lapworth Museum of Geology in Birmingham (United Kingdom) successfully undertook a £2.5 million redesign to restore its heritage, and to adapt its specialist-focused displays for public visitors. This essay unearths the museum's past to argue that previous displays, which required the pedagogy of geological professors to illuminate the objects for the museum's specialist visitors, are replaced by a multimedia display strategy which embeds the history of the museum's geologists within the exhibit narrative, bridging the gap between specialist and public knowledge, transforming the Lapworth into a 'museum at a university' rather than a 'university museum'.
Exclusion of Men from Randomized Phase III Breast Cancer Clinical Trials
Authors: Corrigan Kelsey L. , Mainwaring Walker , Miller Austin B. , Lin Timothy A. , Jethanandani Amit , Espinoza Andres F. , Piotrowski Matt , Fuller C. David , Stauder Michael C. , Shaitelman Simona F. , Perkins George H. , Woodward Wendy A. , Giordano Sharon H. , Smith Benjamin D. , Ludmir Ethan B. 
Published: April 2020

Abstract
Male breast cancer treatment regimens are often extrapolated from female-based studies because of a paucity of literature analyzing male breast cancer. Using ClinicalTrials.gov, we analyzed breast cancer randomized clinical trials (RCTs) to determine which factors were associated with male-gender inclusion. Of 131 breast cancer RCTs identified, male patients represented 0.087% of the total study population, which is significantly less than the proportion of male patients with breast cancer in the U.S. (0.95%; p &lt; .001). Twenty-seven trials included male patients (20.6%). Lower rates of male inclusion were seen in trials that randomized or mandated hormone therapy as part of the trial protocol compared with trials that did not randomize or mandate endocrine therapy (2.5% vs. 28.6% male inclusion; p &lt; .001). It is imperative for breast cancer clinical trials to include men when allowable in order to improve generalizability and treatment decisions in male patients with breast cancer.
Isolation of a lytic bacteriophage vB_EfaS_PHB08 and its endolysin lys08 against Enterococcus faecalis biofilm
Authors: Yang Dan , Chen Yibao , Sun Erchao , Hua Lin , Peng Zhong , Chen Huanchun , Wu Bin 
Published: April 2020

Abstract
Background: Enterococcus faecalis is an opportunistic pathogen can cause a variety of diseases, such as urinary tract infections and wound infections in human and animals. Recently, bacteriophages and their derivatives represent a good effect on fighting against bacterial infections. Methods: We isolated virulent bacteriophages of E. faecalis using the double-layer plate method. The bio-activities of the phage isolated were determined via one-step growth curve testing and bacterial killing assays. Illumina HiSeq sequencing was performed to determine the genetic characteristics and the lysins of the phage. Protein expression and antibiofilm assays were also performed to highlight the bio-activities of the phage lysins. Results: We isolated a virulent bacteriophage vB_EfaS_PHB08 (thereafter PHB08) from the sewage nearby hospital. PHB08 possessed a linear double-stranded DNA genome with 55,244 bp in length, which encoded 91 putative coding sequences (CDS). We found that PHB08 could inhibit the growth of host bacteria for 12 h. In vegetable models, PHB08 can reduce 1´105 Colony Forming Units (CFU) of E. faecalis per square centimeter at room temperature (25 °C) for 24 h. In addition, PHB08 and its endolysin can remove the biofilm formed by E. faecalis. Conclusions: A virulent phage and endolysin displayed a good effect on reducing and/or eradicating E. faecalis infection and biofilm.
Automatic Ventral Intermediate Nucleus Localization Based on Anterior Commissure and Posterior Commissure
Authors: Sarno Riyanarto , Sungkono Kelly Rossa , Rifqi Mohammad Ardika , Fahmi Achmad , Turchan Agus , Bajamal Abdul Hafid 
Published: April 2020

Abstract
The ventral intermediate nucleus (Vim) of the thalamus is a brain lesion target for decreasing tremors in Parkinson’s disease patients. Determination of the location of the Vim is challenging because magnetic resonance imaging (MRI) cannot detect it. Several Vim targeting methods have been proposed, such as Coordinate-based targeting and Guiot’s methods. However, these methods are manually implemented by doctors based on MRI data, so the accuracy of the targeting depends on their memory and foresight. This paper proposes a method to automate Vim localization using Coordinate-based targeting and Guiot’s method. Firstly, this paper determines the plane of the anterior commissure (AC) and the posterior commissure (PC) because to enforce medical images and determine the centre as the middle of AC-PC. Secondly, the coordinates are converted from millimetres to voxels in determining the Vim location. The converter is needed because Coordinate-based targeting and Guiot’s method measure the Vim location in millimetres while the three-dimensional images are measured in voxels. This paper also calculates similarity percentages and averages of error results to determine the accuracy and the robustness of automatic Coordinate-based targeting and Guiot’s. The experiments verify Coordinate-based targeting is higher accuracy and more robust than Guiot’s.
A novel method for psychotropic drugs education: An interventional study
Authors: Tabandeh Zahra , Zarshenas Ladan , Mehrabi Manoosh , Nekooeian Ali akbar , Sarani Ebrahim Moghimi 
Published: April 2020

Abstract
Background: Familiarity with and management of drugs side-effects are among nurses’ main educational needs with respect to pharmacological care in psychiatry departments. This study aimed to determine the effects of psychoactive drugs education through mobile phone and group discussion on nursing students’ attitude, satisfaction, and learning.Methods: This interventional study was done in Shiraz University of Medical Sciences in 2018. The participants included 40 nursing students passing the mental health apprenticeship in their 6 th educational semester. The 32 students with inclusion criteria were randomly divided into two groups each containing 16 subjects. The first group underwent the educational intervention through group discussion within the first two weeks of apprenticeship. The second group, on the other hand, received the educational intervention through mobile phones over the second two weeks of the course. The students’ learning, attitude, and satisfaction were assessed before and two weeks after the intervention and were compared two groups. After all, the data were entered into the SPSS statistical software, version 16 and were analyzed using descriptive and inferential (paired and independent t-test) statistics. P<0.05 was considered to be statistically significant.Results: The results showed a significant difference in the two groups’ rate of learning before and after the intervention (p=0.00). However, no significant difference was found between the two groups in this regard (p=0.158). The results also revealed a significant difference in the two groups’ satisfaction with the instruction method before and after the intervention. A significant difference was also observed between the two groups in this regard (p=0.043). Finally, the results indicated that the students in the mobile phone group developed a significantly more positive attitude after the intervention compared to baseline (p=0.038).Conclusions: The study results demonstrated that mobile teaching methods could be effective in students’ learning, satisfaction, and attitude. Thus, further studies are recommended to be conducted on other medical and nursing apprenticeships, so that such methods can be used in clinical education in case of obtaining similar results.
Selection and implementation of SNP markers for parentage analysis in a Chinese crossbred cattle population
Authors: Hu Lirong , Li Dong , Chu Qin , Wang Yachun , Zhou Lei , Yu Ying , Zhang Yuan , Zhang Shengli , Usman Tahir , Xie Zhenquan , Hou Shiyu , Liu Lin , Shi Wanhai 
Published: April 2020

Abstract
Combining direct sequencing method in polymerase chain reaction (PCR) products of deoxyribonucleic acid (DNA) pooling and matrix-assisted laser desorption/ionisation time of flight mass spectrometry (MALDI-TOF MS) genotyping method in individuals, a panel consisting of 50 highly informative single nucleotide polymorphisms (SNPs) for parentage analysis was developed in a crossbred Chinese cattle population. The average minor allele frequency (MAF) was 0.43 and the cumulative exclusion probability for single-parent and both-parent inference met 0.99797 and 0.999999, respectively. The maker-set was then used for parentage verification in a group of 81 trios with the likelihood-based parentage-assignment program of Cervus software. Compared with on-farm records, the results showed that this 50-SNP system could provide sufficient and reliable information for parentage testing with the parental mistakes for mother-offspring and sire-offspring being 8.6% and 18.5%, respectively. Knowledge of these results, we provided one low-cost and efficient method of SNP assays for running paternity testing in crossbred cattle population of Simmental and Holstein in China.
Associations of vascular risk factors, APOE ɛ4 allele, and TOMM40 G allele with cognitive function in Chinese older adults: a community-based study
Authors: Gui Wenjun , Qiu Chengxuan , Li Juan 
Published: April 2020

Abstract
Background : The associations of vascular risk factors (VRFs) , apolipoprotein E (APOE) ɛ4 allele, and translocase of outer mitochondrial membrane 40 (TOMM40) G allele with cognitive function have been investigated mostly in western societies. In the present study, we sought to examine the associations of VRFs, APOE ε4 allele, and TMM40 G allele (rs2075650) with global cognitive function among Chinese older adults, with a focus on potential interactions between VRFs and the susceptibility genes. Methods : This is a cross-sectional study that included 422 participants (mean age 69.2 years, 54.3% female) in the China Longitudinal Ageing Study , who were free of dementia. Data were collected through interviews, clinical examinations, and laboratory tests. The clustering of multiple VRFs was scored by counting the number of VRFs potentially related to cognitive function. Global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Data were analyzed with multiple general linear regression models. Results : Physical inactivity and diabetes were independently associated with performance lower MMSE score ( p <0.05). Moreover, physical inactivity interacted with APOE ε4 and TOMM40 G allele (rs2075650), and diabetes interacted with TOM40 G allele to affect cognitive function, such that having physical inactivity in combination with either APOE ε4 allele or TOMM40 G allele, or having diabetes and TOMM40 G allele, compared to having neither, was significantly associated with markedly lower MMSE scores ( p <0.05). Finally, when four modifiable VRFs (i.e., current smoking, physical inactivity, high LDL-C, and diabetes) were aggregated, an increasing number of having these factors was associated with a decreasing MMSE score in a dose-response manner ( p for trend<0.05). Conclusion : Some VRFs (e.g., physical inactivity and diabetes), when concurrently occurring with APOE ε4 or TOMM40 G allele, are associated with substantially poor performance in global cognitive function among the Chinese elderly .
Short-term efficacy comparison between helical tomotherapy and intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma
Authors: Cui Zhen , Liu Jia , Sun Qiaoyu , Wang Chaoge , Fang Meifang , He Zelai , Li Duojie , Jiang Hao 
Published: April 2020

Abstract
Background: To evaluate short-term safety and efficacy of helical tomotherapy (HT) versus intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).Methods: Retrospective analysis of locally advanced nasopharyngeal carcinoma treated with radiotherapy and concurrent platinum based neoadjuvant chemotherapy (cisplatin 80 mg/m2 every 3 weeks for 1 cycle) in our hospital from February 2017 to October 2019, including 70 patients in HT group and 70 in IMRT group. The target area of ​​the tumor was delineated by magnetic resonance (MRI) imaging. The prescription doses delivered to the gross tumor volume (pGTVnx) and positive lymph nodes (pGTVnd), the high risk planning target volume (PTV1), and the low risk planning target volume (PTV2), were 69.96 Gy, 66-70 Gy, 60 Gy and 50-54 Gy, in 33 fractions, respectively. Acute reactions were evaluated according to the RTOG/EORTC criteria, whereas the therapeutic efficacy was assessed according to RECTST version 1.1 criteria in a 3-months period.Results: The CI of PGTVnx, PGTVnd, PTV1 and PTV2, and HI of PGTVnx, PTV1 and PTV2 in HT group was significantly better than those in IMRT group. The OAR Dmax and Dmean in HT group were better than those in IMRT group with a significant difference (all p <0.05). Patients in the HT group were significantly better than those in the IMRT group in the protection of acute parotid gland injury and hearing damage (p <0.05), but not other acute adverse reaction. No significant difference was found on the short-term efficacy illustrated by ORR between HT group and IMRT group (x2 = 0.119; p = 0.730).Conclusions: Compared with IMRT, HT has better radiophysical-related dosimetric advantages in radiotherapy for locally advanced nasopharyngeal carcinoma. Despite similar on short-term effects, HT has lower incidence of adverse reactions than IMRT.
Prognostic Factors for Outcome and Survival after Laparotomy in Patients with Pancreatic Trauma: One Single-center Experience.
Authors: Yang Chao , Liu Baochen , Wu Cuili , Wang Yongle , Wang Kai , Li Weiqin , ding weiwei 
Published: April 2020

Abstract
Background: Pancreatic trauma results in significant morbidity and mortality. Few studies have investigated the postoperative prognostic factors in patients with pancreatic trauma after surgery. Methods: A retrospective study was conducted on 152 consecutive patients with pancreatic trauma who underwent surgery in Jinling Hospital, a national referral trauma center in China, from January 2012 to December 2019. Univariate and binary logistic regression analyses were performed to identify the perioperative clinical parameters that may affect the morbidity of the patients. Results: A total of 184 patients with pancreatic trauma were admitted during the study period, and 32 patients with nonoperative management were excluded. The remaining 152 patients underwent laparotomy due to pancreatic trauma. Sixty-four patients were referred from other centers due to postoperative complications. Abdominal bleeding caused by pancreatic leakage ( 10 of all deaths) and severe intra-abdominal infection (12 of all deaths) were the major causes of mortality. Twenty-eight (77.8%) of the 36 patients who had damage control laparotomy survived. Univariate analysis showed that age, hemodynamic status, and injury severe score (ISS) as well as postoperative serum levels of C-reactive protein (CRP), procalcitonin, albumin and creatinine and the volume of intraoperative blood transfusion had significant effects on the mortality ( P <0.05). Binary logistic regression analysis showed that the independent risk factors for prognosis after pancreatic trauma surgery were age ( P =0.012), preoperative hemodynamic instability ( P =0.018), postoperative CPR ≥154 mg/L ( P =0.016), and postoperative serum creatinine ≥177 μmol/L ( P =0.017). The 30-day mortality rate was 15.8%. Conclusions: In this single-center retrospective study, we first demonstrated that severe intra-abdominal infection and bleeding were the major factors affecting the prognosis of patients with pancreatic trauma after surgery. Preoperative hemodynamic instability, severe postoperative inflammation (CRP ≥154 mg/L) and acute renal failure (creatinine ≥177 μmol/L) were associated with a significant risk of mortality.
Angiotensin-Converting Enzyme inhibitors (ACE inhibitors) and Angiotensin II Receptor Blockers (ARBs) role in SARS-CoV-2 infection: A Rapid Systematic Review
Authors: Junior Haliton Alves de Oliveira , Matuoka Jessica Yumi , Parreira Patrícia do Carmo Silva , Brito Gabriela Vilela de , Marra Lays Pires , Medeiros Flávia Cordeiro de , Junior Álvaro Avezum 
Published: April 2020

Abstract

No medications specific treatments are known to be effective for COVID-19 until now. Several drug therapies are being used to optimize supportive care to relieve symptoms. Some observational and essentially theoretical studies have shared opposite opinions regarding the use of ACE inhibitors and ARBs in SARS-CoV-2 infected patients. Therefore, the aim of this review is to evaluate the relationship between ACE inhibitors and ARBs use and clinical effects in COVID-19 patients to guide clinicians for their medical early decision. Electronic searches were conducted on Embase, Medline via PubMed and ClinicalTrials.gov. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was followed and adapted the research as a rapid review. Due to the emergency of the COVID-19 pandemic, any research in English, Portuguese or Spanish that discuss the mechanism of action, in vitro studies and those that draw conclusions based on observational or experimental studies were included. No studies were excluded based on the participant’s clinical or demographical characteristics. The risk of bias was assessed by one reviewer and checked by a second reviewer, using the Joanna Briggs Institute Checklist for Case Series. Any other mechanistic, theoretical or in vitro studies were evaluated as high risk of bias for clinical. Out of 64 studies retrieved, 17 were included in the review. Three studies suggest that both medications may increase the risk of worsening COVID-19, while three suggest they could be beneficial. Currently, there are seven ongoing trials on ARBs and ACE inhibitors. The available evidence does not allow us to draw definite conclusions on either harm or benefit of these medications in the presence of COVID-19. Discontinuing the therapy may be hasty and more robust evidence-based research is needed.
Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles
Authors: Prasad Malavattu G. , Lakshmi Chapala V. , Katari Naresh K. , Pal Manojit 
Published: April 2020

Background:
The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its
prevalence in compounds possessing a wide range of pharmacological properties including anticancer/antitumor
activities. Though a number of methods have been reported for the synthesis of this class of compounds, some of
them are not straightforward, inexpensive and environmentally friendly.

Objective:
To synthesize 2-amino-1,3,4-thiadiazole derivatives that could act as potential anticancer agents.

Methods:
The use of lemon juice as an inexpensive and readily available biocatalyst was explored in the synthesis
of 2-amino 1,3,4-thiadiazole derivatives. Accordingly, a convenient method has been developed for the rapid synthesis
of this class of compounds under a mild and non-hazardous reaction condition in good yields. The methodology
involved the reaction of various acid hydrazides with TMSNCS in the presence of lemon juice in PEG-400 at
room temperature (25-30ºC) under ultrasound irradiation. These compounds were assessed for their cytotoxic properties
against two different metastatic breast cancer cell lines e.g., MDAMB-231 and MCF-7 and subsequently
against SIRT1.

Results:
The 2-amino 1,3,4-thiadiazole derivatives 3a, 3i, 3j and 3l showed promising growth inhibition of MDAMB-
231 and MCF-7 cell lines and SIRT1 inhibition in vitro. Indeed, 3i was found to be a potent inhibitor of SIRT1.

Conclusion:
An ultrasound-assisted method facilitated by lemon juice has been developed to synthesize 2-amino-
1,3,4-thiadiazole derivatives that could act as potential anticancer agents.
3 (2) Factorial Design Assisted Crushed Puffed Rice-HPMC-Chitosan based Hydrodynamically Balanced System of Metoprolol Succinate
Authors: Soni Shashank , Ram Veerma , Verma Anurag 
Published: April 2020

Introduction:
Hydrodynamically balanced system (HBS) possesses prolonged and continuous
delivery of the drug to the gastrointestinal tract which improves the rate and extent of medications
that have a narrow absorption window. The objective of this work was to develop a Hydrodynamically
Balanced System (HBS) of Metoprolol Succinate (MS) as a model drug for sustained stomach specific
delivery.

Materials and Methods:
Experimental batches were designed according to 3(2) Taguchi factorial design. A total of 9
batches were prepared for batch size 100 capsules each. Formulations were prepared by physically
blending MS with polymers followed by encapsulation into hard gelatin capsule shell of size 0. Polymers
used were Low Molecular Weight Chitosan (LMWCH), Crushed Puffed Rice (CPR), and Hydroxypropyl
Methylcellulose K15 M (HPMC K15M). Two factors used were buoyancy time (Y1) and
time taken for 60% drug release (T60%; Y2).

Results:
The drug excipient interaction studies were performed by the thermal analysis method which
depicts that no drug excipient interaction occurs. In vitro buoyancy studies and drug release studies revealed
the efficacy of HBS to remain gastro retentive for a prolonged period and concurrently sustained
the release of MS in highly acidic medium. All formulations followed zero-order kinetics.

Conclusion:
Developed HBS of MS with hydrogel-forming polymers could be an ideal delivery system
for sustained stomach specific delivery and would be useful for the cardiac patients where the prolonged
therapeutic action is required.
SVM Ensemble-based Noise Detection Method for Image Denoising
Authors: Jia Xiaofen , Wang Chen , Guo Yongcun , Zhao Baiting , Huang Yourui 
Published: April 2020

Background:
To preserve sharp edges and image details while removing noise, this paper
presents a denoising method based on Support Vector Machine (SVM) ensemble for detecting
noise.

Methods:
The proposed method ISVM can be divided into two stages: noise detection and noise
recovery. In the first stage, local binary features and weighted difference features are extracted as
input features vector of ISVM, and multiple sub-SVM classifiers are integrated to form the noise
classification model of ISVM by iteratively updating the sample weight. The pixels are divided into
noise points and signal points. In the noise recovery stage, according to the classification results of
the previous stage, only the gray value of the noise point is replaced, and the replacement value is
the weighted mean value with the reciprocal of the quadratic square of the distance as the weight.

Results:
Finally, the replacement value at the noise point and the original pixel value of the signal
point are reconstructed to get the denoised image.

Conclusion:
The experiments demonstrate that ISVM can achieve a noise detection rate of up to
99.68%. ISVM is highly effective in the denoising task, produces a visually pleasing denoised image
with clear edge information, and offers remarkable improvement compared to that of the BPDF
and DAMF.