bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of K562 Cells Functional Inhibitors Based on Machine Learning Approaches
Authors: Zhang Yuan , Han Zhenyan , Gao Qian , Bai Xiaoyi , Zhang Chi , Hou Hongying 
Published: November 2019

Background:
β thalassemia is a common monogenic genetic disease that is very harmful to human
health. The disease arises is due to the deletion of or defects in β-globin, which reduces synthesis of the β-globin
chain, resulting in a relatively excess number of α-chains. The formation of inclusion bodies deposited on the cell
membrane causes a decrease in the ability of red blood cells to deform and a group of hereditary haemolytic diseases
caused by massive destruction in the spleen.

Methods:
In this work, machine learning algorithms were employed to build a prediction model for inhibitors
against K562 based on 117 inhibitors and 190 non-inhibitors.

Results:
The overall accuracy (ACC) of a 10-fold cross-validation test and an independent set test using Adaboost
were 83.1% and 78.0%, respectively, surpassing Bayes Net, Random Forest, Random Tree, C4.5, SVM, KNN
and Bagging.

Conclusion:
This study indicated that Adaboost could be applied to build a learning model in the prediction of
inhibitors against K526 cells.
Repurposing Pathogenic Variants of DMD Gene and its Isoforms for DMD Exon Skipping Intervention
Authors: Tyagi Rahul , Kumar Sumit , Dalal Ashwin , Mohammed Faruq , Mohanty Manju , Kaur Paramvir , Anand Akshay 
Published: November 2019

Background:
Duchenne Muscular Dystrophy (DMD) is a progressive, fatal neuromuscular
disorder caused by mutations in the DMD gene. Emerging antisense oligomer based exon skipping
therapy provides hope for the restoration of the reading frame.

Objectives:
Population-based DMD mutation database may enable exon skipping to be used for the benefit
of patients. Hence, we planned this study to identify DMD gene variants in North Indian DMD cases.

Methods:
A total of 100 DMD cases were recruited and Multiplex ligation-dependent probe amplification
(MLPA) analysis was performed to obtain the deletion and duplication profile.

Results:
Copy number variations (deletion/duplication) were found in 80.85% of unrelated DMD
cases. Sixty-eight percent of cases were found to have variations in the distal hotspot region (Exon 45-
55) of the DMD gene. Exon 44/45 variations were found to be the most prominent among single exon
variations, whereas exon 49/50 was found to be the most frequently mutated locations in single/
multiple exon variations. As per Leiden databases, 86.84% cases harboured out-of-frame mutations.
Domain wise investigation revealed that 68% of mutations were localized in the region of spectrin
repeats. Dp140 isoform was predicted to be absent in 62/76 (81.57%) cases. A total of 45/80
(56.25 %) and 23/80 (28.70%) DMD subjects were predicted to be amenable to exon 51 and exon 45
skipping trials, respectively.

Conclusion:
A major proportion of DMD subjects (80%) could be diagnosed by the MLPA technique.
The data generated from our study may be beneficial for strengthening of mutation database in the
North Indian population.
Identification of Two Novel Mutations in the ATM Gene from Patients with Ataxia-Telangiectasia by Whole Exome Sequencing
Authors: Heidari Masoud , Soleyman-Nejad Morteza , Taskhiri Mohammad H. , Shahpouri Javad , Isazadeh Alireza , Ahangari Roghayyeh , Mohamadi Ali R. , Ebrahimi Masoumeh , Karimi Hadi , Bolhassani Manzar , Karimi Zahra , Heidari Mansour 
Published: November 2019

Background:
Ataxia telangiectasia (AT) is one of the most common autosomal recessive
hereditary ataxia presenting in childhood. The responsible gene for AT designated ATM (AT, mutated)
encodes a protein which is involved in cell cycle checkpoints and other responses to genotoxicity.
We describe two novel disease-causing mutations in two unrelated Iranian families with Ataxiatelangiectasia.

Methods:
The probands including a 6-year-old female and an 18-year-old boy were diagnosed with
Ataxia-telangiectasia among two different Iranian families. In this study, Whole-Exome Sequencing
(WES) was employed for the detection of genetic changes in probands. The analysis of the cosegregation
of the variants with the disease in families was conducted using PCR direct sequencing.

Results:
Two novel frameshift mutations, (c.4236_4236del p. Pro1412fs) and (c.8907T>G p.
Tyr2969Ter) in the ataxia telangiectasia mutated ATM gene were detected using Whole-Exome Sequencing
(WES) in the probands. These mutations were observed in two separate A-T families.

Conclusion:
Next-generation sequencing successfully identified the causative mutation in families with
ataxia-telangiectasia. These novel mutations in the ATM gene reported in the present study could assist
genetic counseling, Preimplantation Genetic Diagnosis (PGD) and prenatal diagnosis (PND) of AT.
Telecollaboration and genres: a new perspective to understand language learning
Authors: Rampazzo Laura , Aranha Solange 
Published: November 2019

The purpose of this paper is to investigate the first 15 minutes of ten initial Teletandem Oral Sessions (iTOS), which means the first virtual encounter among speakers of different languages who want to study the each other’s language. Our aim is to verify iTOS genre status within a telecollaborative learning environment. We understand genres as communicative events organized in standard structures used by members of a discourse community to achieve their communicative purposes (Swales, 1990) and assume that the teletandem context is composed of a specific community with shared objectives. A study of iTOS had first been proposed by Aranha (2014), who analyzed nine iTOS and identified some recurrence in their discoursal structure. Our data, ten iTOS, are part of a previous version of MulTeC (Multimodal Teletandem Corpus) (Aranha & Lopes, forthcoming) and participants are proficient in Portuguese and English. The video files were transcribed and the sessions were analyzed based on Aranha’s (2014) findings. We identified rhetorical organization for the sessions which was similar to Aranha’s, but varied depending on the learning scenarios, i.e. the learning context in which they occurred.
An Assessment on the Housing Auction Market in Selangor
Authors: Zainudin Farah Eleena , Mohamed Osman Mariana , Muhamad Yusop Siti Wahidah , Ibrahim Mansor 
Published: November 2019

The first auction legislation in Malaysia was enacted in the states of Penang and Malacca in 1906. The real estate market including auction market is considered an effective method in selling real estate properties (Chyi, 2015). Auction is one method in selling property in a quick way but this method is consider as force sales as most properties sold due to owner unable to pay the monthly mortgage to the bank. There are advantages of buying property in auction market where the buyer can get the property cheaper than market value and the property usually has a matured environment. The downside of purchasing an auction property is that the buyer is not allowed to view or inspect the inside of the property and sometimes the property is not vacant by the owner. The buyer need to conduct their own research first if they have the intention to buy auctioned property. Based on literatures, there are various considerations for buying auction properties such as the type of properties, the location, value, existing conditions, the existing facilities and infrastructure and many more. This aim of the study is to assess the issues and problems faced by buyers in housing auction market in Selangor. The objectives were to identify the preferred location among the respondents in selection their bidding units. It was found that among respondents, the most preferred location of auction properties was in Gombak. In term of issues and problem in buying auction properties, respondents claimed the issues are the long period of time in getting loan approved and released payment , the title and ownership issues, the units are still occupied by owner, the conditions of units and the overall cost that need to be prepare by buyers. It is hoped that this paper would guide decision maker and government in planning of the overall housing market in Malaysia as properties being auctioned is getting higher over time.Keywords: Auction, Purchaser, Property, SelangoreISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i12.1935
Electronic Screening for Alcohol Use and Brief Intervention by Email for University Students: Reanalysis of Findings From a Randomized Controlled Trial Using a Bayesian Framework
Authors: Bendtsen Marcus 
Published: November 2019

Background
Almost a decade ago, Sweden became the first country to implement a national system enabling student health care centers across all universities to routinely administer (via email) an electronic alcohol screening and brief intervention to their students. The Alcohol email assessment and feedback study dismantling effectiveness for university students (AMADEUS-1) trial aimed to assess the effect of the student health care centers’ routine practices by exploiting the lack of any standard timing for the email invitation and by masking trial participation from students. The original analyses adopted the conventional null hypothesis framework, and the results were consistently in the expected direction. However, since for some tests the P values did not pass the conventional .05 threshold, some of the analyses were necessarily inconclusive.

Objective
The outcomes of the AMADEUS-1 trial were derived from the first 3 items of the Alcohol Use Disorders Identification Test (AUDIT-C). The aim of this paper was to reanalyze the two primary outcomes of the AMADEUS-1 trial (AUDIT-C scores and prevalence of risky drinking), using the same models used in the original publication but applying a Bayesian inference framework and interpretation.

Methods
The same regression models used in the original analysis were employed in this reanalysis (linear and logistic regression). Model parameters were given uniform priors. Markov chain Monte Carlo was used for Bayesian inference, and posterior probabilities were calculated for prespecified thresholds of interest.

Results
Where the null hypothesis tests showed inconclusive results, the Bayesian analysis showed that offering an intervention at baseline was preferable compared to offering nothing. At follow-up, the probability of a lower AUDIT-C score among those who had been offered an intervention at baseline was greater than 95%, as was the case when comparing the prevalence of risky drinking.

Conclusions
The Bayesian analysis allows for a more consistent perspective of the data collected in the trial, since dichotomization of evidence is not looked for at some arbitrary threshold. Results are presented that represent the data collected in the trial rather than trying to make conclusions about the existence of a population effect. Thus, policy makers can think about the value of keeping the national system without having to navigate the treacherous landscape of statistical significance.

Trial Registration
ISRCTN Registry ISRCTN28328154; http://www.isrctn.com/ISRCTN28328154
UPAYA MENINGKATKAN KECERDASAN KINESTETIK MELALUI KEGIATAN MENARI LAGU TOKECANG
Authors: Nuraini Rini 
Published: November 2019

Rini Niraini (2017). Upaya Meningkatkan Kecerdasan Kinestetik Melalui Kegiatan Menari Lagu Tokecang (Penelitian Tindakan Kelas Terhadap Anak Usia Dini Kelompok B Di TK Permata Ibu Cimahi)Penelitian ini bertujuan untuk memperoleh gambaran kondisi objektif kecerdasan kinestetik anak pada kelompok B sebelum diterapkannya kegiatan menari lagu tokecang, memperoleh gambaran mengenai pelaksanaan kegiatan menari lagu tokecaang dalam meningkatkan kecerdasan kinestetik, memperoleh gambaran mengenai peningkatan kecerdasan kinestetik pada anak kelompok B setelah diterapkannya kegiatan menari.Penelitian ini menggunakan metode penelitian tindakan kelas (PTK), yang terdiri dari empat tahapan yaitu 1) Perencanaan, 2) Pelaksanaan Tindakan, 3) Observasi dan Evaluasi, 4) Refleksi. Subjek dalam penelitian ini berjumlah 13 orang anak. Tehnik pengumpulan data ini adalah wawancara, observasi, dan dokumentasi. Tehnik pengumpulan data yang dilakukan adalah deskriptif kuantitatif dengan mengunakan tehnik persentase dengan pelaksanaan beberapa tahapan..Kondisi awal kemampuan kinestetik di TK Permata Ibu Cimahi berada pada kategori berkembang sangat baik (BSB) hanya 8 % dari keseluruhan siswa. Namun setelah diberikan tindakan siklus I pencapaian kemampuan kinestetik anak pada kategori BSB meningkat menjadi 23 %, dan setelah diberikan tindakan siklus II pencapaian perkembangan kemampuan kinestetik anak meningkat kembali menjadi 85 % dari keseluruhan siswa.Berdasarkan hasil analisis dan pembahasan maka dapat disimpulkan bahwa kemampuan kecerdasan kinestetik anak dapat ditingkatkan melalui kegiatan menari lagu tokecang, melalui kegiatan menari ini dapat menstimulasi kemampuan kecerdasan gerak tubuh, serta dapat mengekspresikan diri melalui gerakan menari yang bervariasi, dan mengekspresikan diri dalam gerkan.
MENINGKATKAN KEMAMPUAN PRA KEAKSARAAN ANAK USIA DINI KELOMPOK B MELALUI METODE BERNYANYI DI TK KARTIKA XIX-I
Authors: Sumini Nita , Yulianti Yulianti 
Published: November 2019

Menyanyi adalah suatu kegiatan yang menarik serta dapat mengatasi rasa cemas dan memberikan relaksasi serta ketenangan bagi anak. Melalui nyanyian kegiatan pembelajaran akan terasa lebih menyenangkan. Untuk itu team peneliti berusaha mengetahui sejauh mana metode menyanyi dapat meningkatkan kemampuan bicara anak. Adapun penelitian ini bertujuan: 1) Untuk mengetahui kemampuan awal pra keaksaraan anak usia dini. 2) mengetahui perencanaan metode bernyanyi. 3) Mengetahui proses pelaksanaan metode nyanyian. 4) Untuk mengetahui hasil pelaksanaan metode bernyanyi.Metode yang digunakan adalah Penelitian Tindakan Kelas (PTK). Penelitian ini dilakukan di salah satu Taman Kanak-Kanak yang berada di Kelurahan Sarijadi Kotamadya Bandung. Hasil penelitian diperoleh data mengenai 1) Proses pembelajaran bahasa yang efektif untuk mengembangkan kemampuan pra keaksaraan anak usia dini. 2) Dampak metode bernyanyi terhadap kemampuan pra keaksaraan anak. 3) Faktor-faktor yang mendukung dan menghambat kemampuan pra keaksaraan anak usia dini melalui metode bernyanyi.Rekomendasi penelitian ini diantaranya : 1) Bagi sekolah, perlunya penyediaan sarana prasarana yang digunakan untuk menunjang kemampuan pra keaksaraan anak usia dini. 2) Bagi Pendidik untuk mengetahui penggunaan metode bernyanyi dalam mengembangkan kemampuan pra keaksaraan anak usia dini. 3) Bagi Instansi Pembina, sebagai referensi tentang metode bernyanyi dalam mengembangkan kemampuan pra keaksaraan anak usia dini. Dari hasil Penelitian Tindakan kelas ini dalam disimpulkan bahwa bernyanyi adalah suatu metode yang bisa digunakan untuk meningkatkan kemampuan pra keaksaraan anak usia dini.
UPAYA PENGEMBANGAN DISIPLIN ANAK DENGAN METODE PEMBIASAAN PEMBERIAN KALUNG ANGKA PADA KELOMPOK B3 DI RA AL-JIHAD PADALARANG
Authors: Nurmala Mega 
Published: November 2019

Penelitian ini dilakukan berdasarkan temuan masalah yang terkait dengan kedisiplinan anak pada kelompok B3 di RA Al-Jihad Padalarang. Berdasarka observasi awal menunjukan rendahnya kedisiplinan anak seperti: terlambat datang ke sekolah, berebut tempat saat berbaris, saling mendahului saat mengantri, membiarkan sepatu di halaman, dan berebut tempat penyimpanan tas. Berdasarkan hal tersebut, yang menjadi tujuan dari penelitian ini adalah mengetahui bagaimana perencanaan, pelaksanaan dan evaluasi pengembangan disiplin anak melalui metode pembiasaan pemberian kalung angka. Metode penelitian yang digunakan adalah deskriptif, berbentuk kualitatif. Subjek penelitian ini adalah anak kelompok B3. Teknik dan alat pengumpulan data menggunakan teknik wawancara, observasi, studi dokumentasi dan studi literatur. Dari data yang diperoleh diketahui bahwa metode pembiasaan pemberian kalung angka dalam mengembangkan disiplin anak pada kelompok B3 di RA Al-Jihad Padalarang, sangat efektif serta dikembangkan dan diterapkan dengan baik, konsisten dan konsekuen sehingga kedisiplinan anak berkembang sesuai dengan yang diharapkan. Pengembangan disiplin melalui metode pembiasaan pemberian kalung angka dilakukan setiap hari, setiap anak tiba di sekolah, dan dapat digunakan dalam kegiatan sehari-hari baik di dalam kelas maupun diluar kelas dan menggunakan indikator capaian perkembangan yang ada pada teori-teori kedisiplinan anak usia dini.
MATHEMATICAL COMMUNICATION ABILITY AND SELF CONFIDENCE Experiment with Eleventh Grade Students Using Scientific Approach
Authors: Sumarmo Utari , Mulyani Elis , Hidayat Wahyu 
Published: November 2019

This study is a pre test-post test experiment with control group design having a goal to analyze the role of scientific approach on students’ mathematical communication ability (MCA) and self confidence (SC). The study involves 46 eleventh grade Vocational School students, a mathematical communication test, a mathematical self confidence scale (MSC), and a perception on scientific approach scale. The study found that on MCA and its Normalized Gain (N<G>), students getting treatment with scientific approach attained better grades than the grades of students taught by conventional teaching, but both student’s grades were still at low-medium level. On MSC, there was no different grades between students on both teaching approaches, and those grades were at medium level. The other findings, there is no association between MCA and MSC, and students performed high perception toward scientific approach.
IMPLEMENT THINK TALK WRITE STRATEGY TO LEVEL IT PROBLEM SOLVING ABILITY MATHEMATICS AND SELF CONFIDENT YUNIOR HIGH SCHOOL STUDENT
Authors: Hayati Elah 
Published: November 2019

This writing is result from research that have go to to to study the leveling of problem solving-ability mathematics and self confident student mediating school first with strategy think talk write to be compared ordinary studying. This research to design experiment that use it experiment group method and control group pretes-postes. Population in research this is entire student in a Yunior High School in Kabupaten Subang with class student sample VII E and VII F SMP mentioned. the test Type that to be used is the written test in form decomposing. Postes's quantitative data to be based to through test t to normal data and test Mann Whitney to data not normal levely significant α = 0,05 be obtained that the archievment of problem solving-ability mathematics and self confident student mediating school first groups experiment better than control group. Gain second groups be analyzed to through test-t to normal data and test Mann Whitney to data not normal be obtained that the leveling of problem solving-ability mathematics and self confident student mediating school first groups experiment better than control group. To be concluded that studying with strategy think talk write influency better to problem solving ability mathematics and self confident student VII Yunior High School class than problem solving ability mathematics and self confident student who use it ordinary studying .
Problem Solving Ability and Problem Based Learning
Authors: Nugraha Derry , Ginanjar Heri , Rolina Rosalina 
Published: November 2019

The research was caused by the poor of mathematical problem solving ability of students. This research aimed to compare of mathematical problem solving between students who learned through problem based learning and scientific approach. The method was an experimental method with a pretest-posttest control group design involving two groups and random sampling. At the first and end of learning, the two classes are given a test. The population in this research were Madrasah Aliyah students in Cimahi, while the sample consisted of two randomly selected classes. One class which was given problem based learning and other class was given a scientific approach. The instrument was a set of 5-item mathematical problem solving test description, then those were analyzed with descriptive and inferential statistics using the help of minitab 17 software. Based on the results of the research, the conclusion was the improvement of mathematical problem solving of students using problem based learning was better than students who use a scientific approach.
THE ROLE OF COGNITIVE STAGE TOWARD STUDENTS MATHEMATICAL CREATIVE THINKING AND HABITS OF MIND
Authors: Romdon Ipul Saepul , Puspsowati Amelia Krisna 
Published: November 2019

The purpose of this survey is to examine the role of cognitive stage toward his or her attaiment of mathematical creative thinking (MCT) and habits of mind (HoM) grounded on student’s cognitive stage. The survey concerned with 36 eleventh grade students of 16.25 years old, test of logical thinking (TOLT), an essay MCT test, and a MSC scale. Data analysis covered: calculation of item scoring of HoM scale; percentage enumeration, Mann-Whitney testing for mean difference, of association between two variables, and other rational analysis relevant to the findings. By using TOLT, the survey found that 44% students’ were still at concrete operational stage, few students 19% at transition operational stage, and 36% students had reached at formal operational stage; in entirely, students’ MCT was at low grade level and students’ HoM was at fairly good grade level. Even if, according to cognitive stage, formal students, transition students, and concrete students survey detected successively at medium, low and very low grade level. In line with that findings, formal students realized few difficulties, transition students experienced some more difficulties and concrete students realized difficulties in all items of MCT tasks. In the contrary, either in entirely or according to cognitive stage there were no different grade of MSC among them, and those grades were at fairly good level. The other findings there was high associtaion between cognitive stage and MCT, but no association between cognitive stage and MSC and between MSC and HoM.
IMPROVING CRITICAL THINKING ABILITY AND MATHEMATICAL DISPOSITION OF HIGH SCHOOL STUDENTS THROUGH INTEGRATED SAINTIFIC APPROACH TO BRAIN BASED LEARNING
Authors: Nurbaeti Enen , Sugiharti Meida 
Published: November 2019

The purpose of this study was to examine the problem of achievement and improved critical thinking skills and dispositions mathematical high school students between those who use the scientific approach to integrating brain based learning with a scientific approach , examining the association between variablesand an overview of student performance. This study is an experimental study with a design pretest-posttest design. Sampling in this study using purposive sampling technique . The instruments used were tests and non-tests , the test instruments included tests of mathematical critical thinking skills while the non-test included attitude scale tests Student mathematical disposition . The results showed that the achievement and improvement of critical thinking skills (CTS) with a scientific approach to integrating Brain-based Learning (SAIBBL) better than class with scientific approach (SA). Mathematical Disposition (MD) student in the classroom with using learning (SAIBBL) better than students in class with SA. There is a strong association between CTS and MD . The overall picture of student performance with SAIBBL is superior and students are more active in learning. These results prove that the use of SAIBBL is better than SAI.