bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of molecular and pharmacological switches for chimeric antigen receptor T cells
Authors: Wu Bill X. , Song No-Joon , Riesenberg Brian P. , Li Zihai 
Published: November 2019

Abstract
The use of chimeric antigen receptor (CAR) T cell technology as a therapeutic strategy for the treatment blood-born human cancers has delivered outstanding clinical efficacy. However, this treatment modality can also be associated with serious adverse events in the form of cytokine release syndrome. While several avenues are being pursued to limit the off-target effects, it is critically important that any intervention strategy has minimal consequences on long term efficacy. A recent study published in Science Translational Medicine by Dr. Hudecek’s group proved that dasatinib, a tyrosine kinase inhibitor, can serve as an on/off switch for CD19-CAR-T cells in preclinical models by limiting toxicities while maintaining therapeutic efficacy. In this editorial, we discuss the recent strategies for generating safer CAR-T cells, and also important questions surrounding the use of dasatinib for emergency intervention of CAR-T cell mediated cytokine release syndrome.
Identification of key microRNAs in the carotid arteries of ApoE−/− mice exposed to disturbed flow
Authors: Wang Xinzhou , Gao Shuibo , Dai Liping , Wang Zhentao , Wu Hong 
Published: November 2019

Abstract

Background
Atherosclerosis (AS) is one of the main causes of cardiovascular disease. AS plaques often occur in blood vessels with oscillatory blood flow and their formation can be regulated by microRNAs (miRNAs). The aim of this study is to identify the key miRNAs and molecular pathways involved in this pathological process.

Methods
In this study, gene chip data obtained from the GEO database was analyzed using the LIMMA package to find differentially expressed miRNAs (DE miRNAs) in the carotid arteries of ApoE−/− mice exposed to different blood flow rates. Predicted targets of the DE miRNAs were identified using the TargetScan, miRDB, and DIANA databases respectively, and the potential target genes (PTGs) were found by analyzing the common results of three databases. The DAVID database was used to enrich the PTGs based on gene ontology (GO) and pathway (Kyoto Encyclopedia of Genes and Genomes, KEGG), and the STRING database was used to uncover any protein-protein interactions (PPI) of the PTGs.

Results
The networks of the DE miRNAs-PTGs, Pathway-PTGs-DE miRNAs, and PTGs PPI, were constructed using Cytoscape, and 11 up-regulated and 13 down-regulated DE miRNAs and 1479 PTGs were found. GO results showed that PTGs were significantly enriched in functions such as transcriptional regulation and DNA binding. KEGG results showed that PTGs were significantly enriched in inflammation-related mitogen-activated protein kinase (MAPK) and AS-related FOXO pathways. The PPI network revealed some key target genes in the PTGs.

Conclusions
The analysis of key miRNAs and molecular pathways that regulate the formation of AS plaques induced by oscillatory blood flow will provide new ideas for AS treatment.
Surgical and Surgeon-Related Factors Related to Long-Term Survival in Esophageal Cancer: A Review
Authors: Markar Sheraz R. , Lagergren Jesper 
Published: November 2019

Abstract
Esophagectomy is the mainstay of curative treatment for most patients with a diagnosis of esophageal cancer. This procedure needs to be optimized to secure the best possible chance of cure for these patients. Research comparing various surgical approaches of esophagectomy generally has failed to identify any major differences in long-term prognosis. Comparisons between minimally invasive and open esophagectomy, transthoracic and transhiatal approaches, radical and moderate lymphadenectomy, and high and moderate hospital volume generally have provided only moderate alterations in long-term survival rates after adjustment for established prognostic factors. In contrast, some direct surgeon-related factors, which remain independent of known prognostic factors, seem to influence the long-term survival more strongly in esophageal cancer. Annual surgeon volume is strongly prognostic, and recent studies have suggested the existence of long surgeon proficiency gain curves for achievement of stable 5-year survival rates and possibly also a prognostic influence of surgeon age and weekday of surgery. The available literature indicates a potentially more critical role of the individual surgeon’s skills than that of variations in surgical approach for optimizing the long-term survival after esophagectomy for esophageal cancer. This finding points to the value of paying more attention to how the skills of the individual esophageal cancer surgeon can best be achieved and maintained. Careful selection and evaluation of the most suitable candidates, appropriate and structured training programs, and regular peer-review assessments of experienced surgeons may be helpful in this respect.
Human aldose reductase unfolds through an intermediate
Authors: Sekhon Gurprit , Singh Ranvir 
Published: November 2019

Background: Human aldose reductase (hAR) is the first and rate-limiting enzyme of the polyol pathway. For the development of secondary complications of diabetes in chronic hyperglycemic conditions, one of the critical factors is the increased flux of glucose through the polyol pathway. Due to this clinical implication, hAR attracted considerable attention from the drug discovery perspective. In spite of extensive characterization in the context of biochemical and structural aspects, we know very little about the unfolding behavior of hAR. This study reports equilibrium unfolding studies of hAR. Methods: We carried out thermal denaturation and chemical-induced equilibrium unfolding studies of hAR monitored by circular dichroism and fluorescence spectroscopy. Results: Thermal denaturation studies presented a classical picture of two-state unfolding from native to the denatured state. The data was used to derive thermodynamic parameters and study the thermostability of hAR. Chemical induced equilibrium unfolding studies led us to discover an intermediate state, which gets populated at 3.5-4.0 M and 0.7-2.0 M of urea and GuHCl, respectively. Thermodynamic parameters derived from chemical-induced unfolding are in agreement with those obtained from thermal denaturation of hAR. Conclusion: This study revealed that aldose reductase unfolds from native to the unfolded state via an intermediate. Assessment of the thermodynamic stability of native, intermediate, and unfolded states shows that significant energy barriers separate these states, which ensures the cooperativity of unfolding. As hAR functions in cells that are under osmotic and oxidative stress, these in vitro findings may have implications for its native conformation under the physiological state.
Case Report: Sarcoidosis in the lymph nodes of a breast cancer patient
Authors: Kerio Perwasha , Abid Zain , Abid Masooma , Zehra Desaar , Haider Ghulam 
Published: November 2019

Background: Sarcoidosis is an inflammatory disease that affects multiple organs in the body, especially the lungs and lymph nodes. The coexistence of sarcoidosis and breast cancer has been reported, but the coexistence of both diseases in the same patient often leads to misdiagnosis. Case: We report a case of a 36-year-old woman who presented with concerns of a lump in her left breast along with pain and discharge from the nipple. On examination a 3-cm hard and tender mass was noted in the upper medial quadrant of the left breast with no palpable axillary lymph nodes. The patient was diagnosed with an infiltrating ductal cell carcinoma of the left breast with T2N0M1 Stage IV disease, due to positive mediastinal lymphadenopathy on positron emission tomography scan. The biopsy of mediastinal lymph nodes allowed us to diagnose sarcoidosis and correctly stage her disease as T2N0M0 Stage IIA breast cancer. The patient underwent lumpectomy followed by adjuvant chemo radiotherapy and hormonal therapy - corticosteroids given for sarcoidosis up to 1 year. The patient is doing well 18 months later without recurrence of disease. Conclusion: The simultaneous occurrence of both diseases in the same patient is the risk for misdiagnosis and mismanagement, therefore it is of utmost importance to correctly stage the disease with appropriate investigations and histologic confirmation prior to initiate the treatment for breast cancer.
Mieloma múltiple asociado con hiperbetaglobulinemia en paciente cirrótico. Reporte de caso
Authors: Ramírez Vargas Renán , Vera Marmanillo Verónika , Velazquez Rojas Lida , Pari Caller Charlye Gyorgy 
Published: November 2019

Introducción: el mieloma múltiple es una enfermedad hematooncológica de origen clonal, caracterizada por la producción anormal de células plasmáticas que producen un reemplazo progresivo de otras líneas hematopoyéticas. El 95 % de los casos condiciona el aumento de la producción de inmunoglobulinas defectuosas, predominantemente IgG e IgA, detectadas en suero con pico monoclonal, definido por un deterioro progresivo de la función renal aguda, anemia, citopenias, dolor óseo agudo o crónico, fracturas patológicas, trastornos endocrinos recientes y, como en el caso de estudio, asociado con cirrosis hepática. Presentación del caso: paciente masculino de 49 años, con cefalea, dolor abdominal, torácico, evacuaciones melénicas, disnea y signos de ascitis, con un tiempo de enfermedad de tres meses, con historia de dolor lumbosacro de tres años antes de su ingreso. Los exámenes auxiliares mostraron pancitopenia, perfil de coagulación alterado, función renal alterada, inversión de albúmina-globulina, hiperuricemia, ascitis, lesiones óseas líticas, hipergammapatía monoclonal de tipo IgA relacionado con hiperbetaglobulinemia. Los exámenes específicos dieron como diagnóstico mieloma múltiple IgA EC IIIB más cirrosis hepática. Se presenta este caso como inusual por elevación de proteínas en suero, tanto beta como gamma, producto de dos patologías concomitantes. Conclusión: paciente con dos enfermedades simultáneas, en ambos casos con elevación de globulinas, lo que podría confundir el diagnóstico; el estado de inmunosupresión mejora con la administración de inmunoglobulinas y de tratamiento para la enfermedad base.
Why Won’t You Listen to Me? Measuring Receptiveness to Opposing Views
Authors: Minson Julia A. , Chen Frances S. , Tinsley Catherine H. 
Published: November 2019

We develop an 18-item self-report measure of receptiveness to opposing views. Studies 1a and 1b present the four-factor scale and report measures of internal, convergent, and discriminant validity. In study 2, more receptive individuals chose to consume proportionally more information from U.S. senators representing the opposing party than from their own party. In study 3, more receptive individuals reported less mind wandering when viewing a speech with which they disagreed, relative to one with which they agreed. In study 4, more receptive individuals evaluated supporting and opposing policy arguments more impartially. In study 5, we find that voters who opposed Donald Trump but reported being more receptive at the time of the election were more likely to watch the inauguration, evaluate the content of the inauguration speech in a more even-handed manner, and select a more balanced portfolio of news outlets for later consumption than their less receptive counterparts. We discuss the scale as a tool to investigate the role of receptiveness for conflict, decision making, and collaboration. This paper was accepted by Elke Weber, judgment and decision making.
Reviews
Authors: Cosentino Olivia , Thornton Niamh , Pinazza Natália , Fredrick Sharonah , Ripley Marc 
Published: November 2019

La India María: Mexploitation and the Films of María Elena Velasco, Seraina Rohrer (2018) Austin: University of Texas Press, 220 pp., ISBN 978-1-47731-345-9, p/bk, $29.95 USD
Mexican Transnational Cinema and Literature, Maricruz Castro Ricalde, Mauricio Díaz Calderón and James Ramey (eds) (2017) Oxford and Bern: Peter Lang, 312 pp., ISBN 978-1-78707-066-0, p/bk, $69.95
The Latin American (Counter-)Road Movie and Ambivalent Modernity, Nadia Lie (2017) Cham, Switzerland: Palgrave Macmillan, 260 pp., ISBN: 9783319435534, h/bk, £57.65, p/bk, £71.96
Evolvi ng Images: Jewish Latin American Cinema, Norah Glickman and Ariana Huberman (eds) (2018) Austin: University of Texas Press, 264 pp., ISBN 978-1-47731-471-5, p/bk $29.95 USD
The Spanish Fantastic: Contemporary Filmmaking in Horror, Fantasy and Sci-Fi, Shelagh Rowan-Legg (2016) London and New York: I. B. Tauris, 214 pp., ISBN 978 1 78453 677 0, h/bk, $103.50; e-book, $82.80
Penerapan 5S (Seiri, Seiso, Seiton, Sheiketsu, Shitsuke) pada UKM Olahan Makanan di Dusun Sempu, Desa Wonokerto
Authors: Farihah Tutik , Krisdiyanto Didik 
Published: November 2019

Desa Wonokerto berada di kaki /lereng gunung merapi yang terletak di Kecamatan Turi Kabupaten Sleman Daerah Istimewa Yogyakarta. Secara geografis, Desa Wonokerto terletak pada ketinggian 400 s/d 900 m dari permukaan air laut. Dengan ketinggian tersebut, sebagian besar wilayahnya adalah pertanian. Salak terutama salak pondoh merupakan salah satu produk pertanian unggulan yang dimiliki oleh desa wonokerto. Metode dalam pengabdian masyarakat ini terdapat tiga tahap yakni: pra pelaksanaan (pemetaan masalah, rekomendasi pendampingan/pelatihan yang diberikan dan koordinasi dengan pihak desa dan UKM tersebut), pelaksanaan (FGD dengan perangkat desa dan ukm untuk mengetahui dengan detail permasalahan dari tiap jenis UKM yang ada, pelatihan dan penjelasan mengenai konsep 5S (Seiri, Seiso, Seiton, Sheiketsu, Shitsuke), implemetasi pelaksanaan 5S dan pasca pelaksanaan (monitoring). Output pada pengabdian masyarakat ini adalah: adanya implementasi 5S dalam proses produksi melalui penetaan ulang area produksi, adanya logistic book untuk setiap material yang digunakanWonokerto.[Wonokerto Village is located at an altitude of 400 s/d 900 m above sea level. With these altitudes, most of the area is farming. Salak especially salak pondoh is one of the leading agricultural products owned by the village wonokerto. Methods of community service are three stages: pre-implementation (problem mapping, recommendations of mentoring/training provided and coordination with village and SMEs), implementation (FGDs with government and SME) to find out details of the problems of each type of SME, training and explanation of 5S (Seiri, Seiso, Seiton, Sheiketsu, Shitsuke) related rules, Implementation of 5S and post-implementation (monitoring).Outputs on community service are: Implementation of 5S with relayout the production area, logistic book for every production material.]
CrossAsia-ITR (Integriertes Textrepositorium) – Ziele, Aufbau, Technik
Authors: Kaun Matthias , Schöner Oliver , Siebert Martina 
Published: November 2019

Zusammenfassung
Die Ostasienabteilung der Staatsbibliothek zu Berlin lizenziert für ihre Plattform CrossAsia im Rahmen des FID Asien seit Jahren eine Vielzahl elektronischer Ressourcen aus und über Asien. Über das CrossAsia-ITR sollen diese Daten gesichert und verwaltet und für die Wissenschaft datenbankunabhängig bereitgestellt werden. Der Weg, die Vielfalt an Daten aus verschiedensten kommerziellen Datenbanken in möglichst standardisierter, strukturierter Form im Repositorium abzulegen, ist oft steinig. Hier müssen Fach- und IT-Abteilung eng zusammenarbeiten, um sowohl eine Sicherung und Repräsentation der Originale als auch eine weitgehende Standardisierung der Materialien zu erreichen.
A general MILP based optimization framework to design Energy Hubs
Authors: Götze Jens , Dancker Jonte , Wolter Martin 
Published: November 2019

Abstract
To optimally design integrated energy systems a widely used approach is the Energy Hub. The conversion, storage and transfer of different energy vectors is represented by a coupling matrix. Yet, the coupling matrix restricts the configuration of the Energy Hub and the constraints, that can be included. This paper proposes a MILP based optimization framework, which allows a high variability and adaptability and is based on energy flows. The functionality of the developed framework is tested on four use cases depicting different system sizes and Energy Hub configurations. It is shown that the framework is able to simplify the design process of an Energy Hub.
Exploring the Health Case for Universal Basic Income: Evidence from GPs Working with Precarious Groups
Authors: Johnson Matthew , Degerman Dan , Geyer Robert 
Published: November 2019

Abstract
This article draws upon clinical experience of GPs working in a deprived area of the North East of England to examine the potential contribution of Universal Basic Income to health by mitigating ‘patient-side barriers’ among three cohorts experiencing distinct forms of ‘precariousness’: 1) long-term unemployed welfare recipients with low levels of education (lumpenprecariat); 2) workers on short-term/zero-hours contracts with low levels of education (‘lower’ precariat); 3) workers on short-term/zero-hours contracts with relatively high levels of education (‘upper’ precariat). We argue that any benefits must be accompanied by robust institutions capable of promoting health.
Filler modified by a sequential encapsulation and preflocculation method and its effect on paper properties
Authors: Chen Nannan , Wang Lijun , Wen Junchao , Yao Xianping , Zhao Wenyan 
Published: November 2019

Abstract
Increasing the filler content of sheet tends to decrease filler retention and paper strength properties. To overcome this problem and make better use of fillers, development of new methods on filler modification has never been stopped. In this study, filler modification was carried out by sequentially adding an anionic polyacrylamide, a cationic starch and a cationic polyacrylamide. It is believed that in this process, multiple polyelectrolyte complexes are formed which can not only encapsulate filler particles but also preflocculate the particles. The results showed that, compared to the single preflocculation treatment, the sequential encapsulation and preflocculation (SEP) treatment brought significantly larger particle size and higher surface charge potential of the filler, thus higher filler retention was achieved. When the modified fillers were used for papermaking and paper ash contents were controlled at the same level, the SEP modification was better in improving the tensile index, internal bond strength and tearing index of paper than the single preflocculation method, in addition, it maintained better paper formation, caused insignificant change on opacity of paper. It is believed that this newly developed SEP method is worthy of being applied to industrial scales in making various grades of filled paper.
Applying the concept of entrepreneurial ecosystems in Estonia
Authors: Reidolf Merli , Küttim Merle , Michelson Aleksandr , Rozeik Helena , Kallaste Marianne 
Published: November 2019

Abstract
Similar to natural ecosystems, entrepreneurs and other entrepreneurial actors are locally interdependent and affect the performance of each other. Mostly economically larger and more successful regions have been studied by using the framework of entrepreneurial ecosystems (EEs). The current study aims at further developing the theoretical understanding of EEs and applying the proposed EE model in the context of Estonia. In the study, a conceptual model of an EE is proposed, the uniqueness of which lies in merging three aspects into a single framework: the nine components of an EE, its value-added, and its phase of development. The model was applied for analysing by means of a qualitative methodology four sector-based subEEs in Estonia.
The study showed that even in a small country like Estonia the components of the EE were partly similar, but also partly unique for the subEEs. This was not due to the location, but because of sectoral differences. The difference of the development phase seemed to be related to the knowledge base of the sector.
The policy relevance of the model is that it allows looking at the elements of an EE as well as its economic value-added and development prospects. The EE approach allows addressing jointly the difficulties and challenges in the development of EEs, including the issues of digitalisation, skilled labour, and production costs, which would allow the subEEs to develop into mature and resilient networks. Not all the components of an EE have to be equally strong, but their interconnectedness determines the strength of an EE. Policy solutions need to be tailored to the needs of specific subEEs based on the knowledge base and inner dynamics of the sectors.
THE EFFECTS OF LOGISTICAL AND SUPPLY CHAIN ON THE PERFORMANCE OF SHALLOT FARMERS EAST JAVA
Authors: HERMAWAN La Ode Andi , PRASETYA Arik , WOROKINASIH Saparila 
Published: November 2019

This study aims to analyze and explain logistical activities in the shallot supply chain in East Java Province. Data were collected using a questionnaire from 200 shallot farmers as instruments in the study sample. Data analysis using SEM PLS method with SmartPLS 3.0 software. The results of this study indicate that transportation has a significant influence on integrative supply chains and business performance. This means that the higher the role of partners to producers to prepare transportation in the transportation process will increase integrative supply chain activities so that the business performance of producers will also increase. While the integrative supply chain has a significant influence on business performance. that is, an integrated supply chain between the farmers and partners will improve the results of farmers' business performance.
Keywords: Shallots, transportation, integrative supply chain, business performance
Kiedy car był bogiem, a uczony – rymopisem
Authors: Chojnicka Krystyna 
Published: November 2019

<p>Artykuł dotyczy zjawiska sakralizacji monarchy w literaturze rosyjskiej w XVII w. Było ono obecne w twórczości Michała Łomonosowa. Ten wybitny uczony, organizator nauki, pionier przemysłu, wśród współczesnych znany był przede wszystkim jako poeta. W jego twórczości przeważają panegiryki skierowane do panujących monarchów. Poeta dokonuje w nich porównań cara do Boga lub wprost przypisuje mu cechy boskie. W barokowej poezji Łomonosowa łączyły się one często z obrazem władcy jako mitologicznego bóstwa. Autorka skoncentrowała się na przedstawieniu sytuacji społecznej, w której powstawała taka literatura, jej funkcjach, a także na motywach, którymi Łomonosow kierował się jako twórca tej literatury.</p><p> </p>