bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFORMÁTICA NA EDUCAÇÃO E FORMAÇÃO DE PROFESSORES(AS) DA REDE MUNICIPAL DE GARANHUNS - PE: UMA EXPERIÊNCIA EXTENSIONISTA
Authors: De Noronha Silva Jainy , Aparecida Guimarães Souza Sanny , Medeiros Vanderlei Igor , José Pimentel de Andrade Mariel , Fernandes de Alencar Anderson 
Published: October 2020

O presente trabalho apresenta resultados das atividades desenvolvidas até julho de 2019 no projeto de extensão “Informática, educação e acesso ao conhecimento: fomentando ensino com qualidade sociocultural e inclusão social nas escolas municipais de Garanhuns – PE”, cujo objetivo principal é contribuir para a efetiva utilização da informática na educação nas escolas públicas do município de Garanhuns (PE), bem como viabilizar a continuidade dos projetos de extensão ‘Tecnologias da informação, comunicação e educação: potencializando os processos de ensino e aprendizagem’ (2016), 'Informática e multimídia na educação básica: intensificando a presença de softwares livres com foco educacional no município de Garanhuns (PE)' (2017) e ‘Informática nas escolas municipais de Garanhuns (PE): propiciando formação, acesso e inclusão digital’ (2018). As atividades a serem explanadas tem enfoque no eixo formativo do projeto. No decorrer das ações desse eixo, de 2016 até atualmente, foram realizadas oficinas sobre o sistema operacional e os softwares educativos livres disponibilizados nos netbook do programa “Um Computador por Aluno” (UCA), onde professores, coordenadores, supervisores e gestores da rede municipal de ensino puderam participar. Neste ano de 2019, foi dado início às oficinas sobre o sistema operacional e os softwares educativos livres implantados nos laboratórios de informática das escolas municipais, onde foi possível concretizar as formações continuadas com foco nos desktop. No decorrer dessa ação formativa do projeto foi incentivada a elaboração de planos de aula para utilização dos softwares disponibilizados nos UCAs e desktop; e o envio dos planos para o ambiente virtual e disponibilização dos mesmos para toda a comunidade. Considerando as ações já finalizadas e as que estão em andamento, avançamos consideravelmente quanto a melhorias no âmbito da informática aplicada à educação na rede municipal de Garanhuns, continuamos em atividades neste segundo semestre para desenvolver 3 formações, dentre elas: uso do laboratório de informática, uso dos software livres disponibilizados nos UCAs, metodologias de ciências e informática e uma formação sobre pensamento computacional; publicação dos guias de uso dos softwares livres disponibilizados nos netbook do programa UCA e nos computadores de mesa (desktop) das escolas municipais, e o acompanhamento do uso dos UCAs e dos desktop.
Pengaruh Profitabilitas, Kecukupan Modal, Risiko Kredit Terhadap Dana pihak ketiga serta Implikasinya Terhadap Nilai Perusahaan
Authors: Karolina Karolina 
Published: October 2020

Didalam Penelitian ini tentunya memiliki tujuan yaitu mengetahui seberapa besar pengaruh Profitabilitas, Kecukupan modal, Resiko kredit Terhadap Dana pihak ketiga serta Impikasinya terhadap Nilai perusahaan pada perusahaan Bank Swasta devisa periode tahun 2012 – 2016. Variabel yang digunakan adalah ROA, CAR, NPL, Dana pihak ketiga, dan PER. Dari uji data telah dilakukan yaitu profitabilitas memiliki pengaruh terhadap Dana pihak ketiga, kecukupan modal mempunyai pengaruh terhadap Dana pihak ketiga, resiko kredit tidak memiliiki pengaruh terhadap Dana pihak ketiga dan Dana Pihak Ketiga memiliki pengaruh positif terhadap nilai perusahaan. Dimana variabel profitabilitas, kecukupan modal, dan resiko kredit secara bersamaan memiliki pengaruh positif terhadap Dana pihak ketiga.
COMPUTER MODELING AS A WAY TO IMPLEMENT INTERDISCIPLINARY CONNECTIONS
Authors: Gileva E. E. 
Published: October 2020

The article provides an overview of the lessons of the information portal "Moscow Electronic School" ("Biblioteka MEHSH") on the controlled element of the content of the line "Modeling and formalization". The structure of lessons on computer modeling is proposed, and examples of lessons that can be used to conduct binary lessons by a subject teacher together with a informatics teacher are considered. Computer modeling is presented as a way of implementing interdisciplinary connections in the "aim — result" format.
CHARACTERISTICS, PATTERNS OF PATHOGENS, AND ANTIBIOTICS RESISTANCE OF BACTERIAL MENINGITIS AT RSUP DR. MOHAMMAD HOESIN PALEMBANG
Authors: Okparasta Andika , Susan Dewi , Irfannuddin Irfannuddin 
Published: October 2020

Bacterial meningitis is an inflammation of the meninges, especially arachnoid and pia mater, which occurs due to the invasion of bacteria into the subarachnoid space. Bacterial meningitis cases are distributed throughout the world, with an incidence of 2-6 / 100,000 people per year with a peak incidence in infants, adolescents, and the elderly. This study was a retrospective cross-sectional descriptive study to look for sociodemographic characteristics, pathogens and resistance patterns, and clinical outcomes of bacterial meningitis patients at dr. Mohammad Hoesin Palembang. There were 43 cases of bacterial meningitis, and only 13 cases met the inclusion and exclusion criteria. Most cases of bacterial meningitis were in the 30-45 years (30%) and 46-55 years (30%) age groups, with predominantly female patients (69%). The most noted clinical manifestations were fever and neck stiffness (100%). decreased consciousness (92%), hemiparesis (77%), headache (70%) and seizures (54%). The mortality rate of bacterial meningitis patients reached 53% with a disability rate reaching 39%. Pathogens found based on culture results were Staphylococcus sp. (69%), Acinetobacter baumanii (5.3%), Klebsiella pneumonie (15%), Shigella somnei, and E. coli (5.3%). Antibiotic resistance to Staphylococcus sp. Was quite high, namely Erythromycin and Oxacillin reaching 77%, Trimethoprim / Sulfamethoxazole 55%, Ciprofloxacin, Clindamycin, levofloxacin reached 33%. Higher mortality was found in patients with drug resistance.
Bronchial obstruction and resistance to hypoxia in elderly patients with COPD
Authors: Asanov E.O. , Holubova Yu.I. , Diba I.A. , Asanova S.O. , Voynarovskaya G.P. 
Published: October 2020

Background. Age-related morphofunctional changes in the body lead to the development of arterial hypoxemia, tissue hypoxia and hypoxic changes. All this causes a decrease in the body’s resistance to hypoxia and contributes to the development of lung diseases, in particular, chronic obstructive pulmonary disease (COPD) in the elderly. With the development of COPD in the elderly due to bronchial obstruction and disorders of pulmonary gas exchange, age-related hypoxic shifts, arterial hypoxemia, tissue hypoxia and resistance to hypoxia are further reduced. However, the relationship between bronchial obstruction and resistance to hypoxia in elderly patients with COPD has not been studied.
Objective. To identify the relationship between bronchial patency and resistance to hypoxia in elderly patients with COPD.
Materials and methods. The study included 30 patients with COPD in the elderly (60-74 years), I-II stage, without exacerbation, with a disease duration of 7 to 26 years, risk groups A and B. The type and severity of pulmonary ventilation were assessed indicators of spirometry and the curve “flow/volume” of forced exhalation on the device Spirobank (Mir, Italy). To determine the body’s resistance to hypoxia, a hypoxic test with 12 % oxygen content was performed for 12 min with monitoring of blood saturation using the automated software and hardware complex Hypotron (Ukraine).
Results. Researches have shown that under hypoxic exposure, blood saturation in elderly patients with COPD is reduced, on average, by 18.23±0.26 %. This decrease in blood saturation can be regarded as severe arterial hypoxemia. At the same time, in elderly patients with COPD with an increase in bronchial patency disorders, the saturation shifts in hypoxia, on average, also increase. There was a significant correlation (r=0.50; p=0.006) of blood saturation shifts in hypoxia with bronchial obstruction.
Conclusions. In elderly patients with COPD, resistance to hypoxia is determined by bronchial obstruction.
The possibility of using silochrome sorbents for proteinase inhibitor aprotinin
Authors: Braginets O.G. , Ivasyk V.V. , Kondratskyi B.O. , Kachmaryk D.L. , Novak V.L. 
Published: October 2020

Background. Aprotinin is a polypeptide, a proteinase inhibitor of natural origin. It inhibits kallikrein, kininogenase, plasmin, trypsin, chymotrypsin; blocks the activator of profibrinolysin, which helps to stop bleeding. Aprotinin is obtained from the lungs of cattle.
Objective. To study the sorption of aprotinin on silochromic sorbents.
Materials and methods. Affinity sorbents based on silochrome were used in the work: p-chlorobenzyl-silochrome, active bright blue K-silochrome, aminopropyl silochrome, phenyl-diol-silochrome, phenyl-glutaryl-silochrome. The optical density was measured on KFK-3 (590 nm, 750 nm) and SF-46 (280 nm). An NP-3 peristaltic pump was used for chromatographic purification.
Results and discussion. Based on the obtained data, it can be assumed that the mechanism of binding of aprotinin to all carriers is obviously the same and is based on the presence of hydrophobic sites in its molecule, which leads to hydrophobic interactions with sorbents. However, increasing the hydrophobicity of the eluent does not lead to desorption of the inhibitor. Obviously, in addition to hydrophobic, a significant role is played by the electrostatic interaction, which is eliminated by increasing the ionic strength. The sorbents under study have a high capacity, they do not change their volume when the ionic strength or hydrophobicity changes, and therefore may be suitable for large-scale applications.
Conclusions. Affinity sorbents based on silochrome, containing as ligands aminobenzene, p-chlorobenzyl chloride and active chlorotriazine dye of the anthraquinone series “active bright blue K”, in contrast to the original matrix – silochrome aminopropyl water and effectively dissolve. Increasing the ionic strength or hydrophobicity of desorbing solutions does not lead to elution of aprotinin due to additional electrostatic interaction. Therefore, the desorption of aprotinin is achieved only if it is eliminated in the presence of 25 % isopropanol with 1M NaCl.
Features of infusion chemotherapy with first-line drugs in patients with tuberculous meningitis and HIV
Authors: Butov D.O. , Kuzhko M.M. , Gumeniuk M.I. , Butova T.S. 
Published: October 2020

Objective. To investigate the effectiveness of first-line intravenous drugs (isoniazid and ethambutol) in patients with tuberculous meningitis and HIV during the intensive phase of chemotherapy.
Materials and methods. 54 patients with newly diagnosed infiltrative pulmonary tuberculosis, tuberculous meningitis, and HIV were included in this study. The presence of Mycobacterium tuberculosis in sputum was observed in all patients. Group 1 consisted of 23 patients receiving ethambutol and isoniazid intravenously, and rifampicin and pyrazinamide were administered orally. Group 2 consisted of 31 patients treated with first-line oral anti-tuberculosis drugs. Serum isoniazid and ethambutol concentrations were determined by chromatographic method.
Results. There was a greater improvement in clinical symptoms and radiographic evidence in patients receiving intravenous isoniazid and ethambutol compared with group 2. Positivity of sputum Mycobacterium tuberculosis was observed during the second month of treatment in 25.0 % of patients in group 1 and 76.1 % of patients in the control group (p=0.003). In addition, 9 (39.1 %) patients died before 6 months when isoniazid and ethambutol were administered intravenously compared with 22 (70.9 %) in group 2 (p=0.023).
Conclusions. In tuberculous meningitis and HIV, intravenous treatment with isoniazid and ethambutol was more effective than oral treatment for 2 months of intensive treatment in the form of faster sputum conversion, clinical improvement, and higher mean concentrations of isoniazid and ethambut blood. In addition, mortality was lower with intravenous isoniazid and ethambutol compared with oral treatment.
Fluorescent in situ hybridization in patients with chronic lymphocytic leukemia with autoimmune hemolytic anemia
Authors: Valchuk M.O. , Zotova O.V. , Lukyanova A.S. , Vyhovska O.Ya. , Karo Yu.S. , Lukavetsky L.M. , Vyhovska Ya.I. , Logininsky V.E. , Shalay O.O. 
Published: October 2020

Background. Gene aberrations are an important prognostic criterion for the course of B-cell chronic lymphocytic leukemia (B-CLL) and response to treatment, which includes not only immunochemotherapy, but also concomitant infusion therapy for the prevention and correction of complications.
Objective. To investigate the presence of prognostic cytogenetic changes in patients with B-CLL with autoimmune hemolytic anemia (AIGA). To analyze the course of the disease and the direct effect of treatment in patients with cytogenetic changes of different nature.
Materials and methods. Cytogenetic studies were performed by fluorescent in situ hybridization (FISH) on the interphase nuclei of peripheral blood lymphocytes in 11 patients with B-CLL with AIGA. Probes to the ATM genes (gene localized in region 11q23) and TP53 (gene localized in region 17p13) were used in the work, the deletions of which have prognostic value in B-CLL. All patients received treatment.
Results. Among 11 patients with AIGA, signals to both genes were detected in nuclei 4. No deletions were detected. In the cells of the other 7 patients, the absence of a single signal to the ATM gene was detected, indicating the presence of a deletion of del(11)(q23). In recent patients, an unfavorable course of B-CLL disease was observed without response to treatment. Deletions of the TP53 gene in patients of the studied group were not detected.
Conclusions. FISH study in patients with B-CLL with AIGA revealed the presence of important and prognostically unfavorable chromosomal rearrangement of the ATM gene in 63 % of patients.
The relevance of infusion and transfusion therapy in obstetric practice
Authors: Indiaminova G.N. 
Published: October 2020

Objective. To improve the outcomes of treatment of massive bleeding in obstetrics in combination with infusion-transfusion therapy (ITT).
Materials and methods. Clinical and laboratory study of 16 women with bleeding in the early postpartum period (EPP).
Results and discussion. We examined 16 women with bleeding for various reasons in the EPP. Of these, in 4 (25 %) women, the cause of bleeding in the postpartum period was trauma to the birth canal, in 2 (12.5 %) women there was dense attachment of the placenta, in 3 (18.75 %) women, bleeding in the EPP was observed due to the remainder of parts placenta and membranes in the uterine cavity, 3 (18.75 %) women had uterine hypotension due to an overstretched uterus due to the birth of a large fetus, twins and prolonged labor, 1 (6.25 %) women had gestosis and a history uterine fibroids. Patients with massive bleeding, regardless of the method of delivery, were characterized by a significant increase in the incidence of coagulopathy as a cause of postpartum hemorrhage (more than 18.75 %). Factors increasing the risk of massive blood loss were uterine fibroids (6.25 %) and gestosis (12.5 %). The estimate of blood loss, calculated with an additional coefficient (with the visual method +30 % of the estimated value, with the gravimetric method +20 %), corresponded to the objective data as much as possible. Underestimation of blood loss occurred in less than half of cases (43.75 %) and did not exceed 100 ml. Presenting the volume of bleeding as a percentage of body weight proved to be an effective way to combat underestimation of obstetric blood loss, which indicated the timely initiation of ITT. The use of transfusion agents (fresh frozen plasma and erythromass in 56.25 % of cases) allowed to avoid severe coagulopathic disorders, prevented severe anemia, and neutralized hemoconcentration deviations.
Conclusions. The effectiveness of the ITT standard in massive postpartum hemorrhage is confirmed by the absence of maternal mortality, cases of severe anemia in the postpartum period, significant differences in the number of postpartum infectious and inflammatory complications and the timing of patients’ discharge.
Efficacy of infusion chemotherapy in patients with pulmonary tuberculosis with treatment failure and malabsorption syndrome
Authors: Kuzhko M.M. , Butov D.O. , Tlustova T.V. , Grechanyk L.I. 
Published: October 2020

Objective. To investigate the effectiveness of infusion chemotherapy in patients with pulmonary tuberculosis (TB) with treatment failure and malabsorption syndrome.
Materials and methods. We observed 52 patients with newly diagnosed pulmonary TB with treatment failure, who were diagnosed with malabsorption syndrome. Patients were divided into two groups: 1st group (main) included 24 patients who received rifampicin and ethambutol intravenously, pyrazinamide and isoniazid orally; 2nd group (control) – 28 patients who received standard therapy orally. The severity of malabsorption syndrome was determined by a violation of intestinal penetration. Intestinal penetration was determined by the concentration of lactulose and mannitol (lactulose-mannitol test) in urine. The concentration of rifampicin, isoniazid, ethambutol in the serum was determined by liquid chromatography on a chromatograph Perkin Elmer (USA).
Results and discussion. The examination revealed a violation of the rate of intestinal penetration in all studied patients, compared with healthy donors. The concentration of anti-TB drugs in the serum was significantly lower than the therapeutic average in group 2 compared with group 1 (p<0,05). In patients of group 1 after the intensive phase of treatment, the disappearance of clinical symptoms of the disease was observed in 22 (91.3±5.8 %) and 17 (60.7±6.3 %) patients (p<0.05), cessation of mycobacterial excretion – in 20 (83.3±4.3 %) and 14 (50.4±4.6 %) (p<0.05), resorption of infiltrative changes and healing of destruction cavities in the lungs – in 12 (50.2±5.3 %) and 10 (35.7±4.7 %) (p<0.05) compared with group 2.
Conclusions. In patients with malabsorption syndrome with ineffective treatment and low intestinal penetration, which leads to reduced serum concentrations of anti-TB drugs in the intensive phase of treatment, it is advisable to increase the effectiveness of intravenous rifampicin and ethambutol.
Comparative study of the influence of colloid-hyperosmolar and protein-salt solutions on anti-inflammatory and detoxification processes in rats with burn shock
Authors: Ocheretnyuk A.O. , Kondratsky B.O. , Palamarchuk O.V. , Vashchuk V.A. 
Published: October 2020

Objective. Experimentally justify the use of colloidal-hyperosmolar solution based on hydroxyethyl starch HAES-LX-5 % and protein-salt solution based on albumin Lactoprotein with sorbitol (LPS) in burn shock (BS).
Materials and methods. The experiments were performed on an experimental model of OS in white male rats. HAES-LX-5 %, LPS solution and control 0.9 % NaCl solution at a dose of 10 ml/kg/day for 7 days were used for infusion therapy. The blood leukocyte intoxication index (LII), medium weight molecules (MWM), C-reactive protein (CRP) were studied.
Results and discussion. In the conditions of experimental BS with the introduction of 0.9 % NaCl, the LII on the 7th day significantly increased by 5.37 times (p<0.01) compared with intact animals (0.887±0.108 and 0.165±0.098, respectively). This indicates the development of destructive processes and intoxication of rats in BS. When HAES-LX-5 % and LPS were administered, LII increased only 2.33 times (p<0.01) and 2.41 times (p <0.05) and was significantly lower compared to 0.9 % NaCl. In animals from the group of control pathology there was an increase in blood levels of MWM, on the 1st day by 75.6 %, on the 3rd day – by 159.5 %, and on the 7th day – by 128.0 %, respectively, compared with intact animals. A systemic inflammatory reaction was also formed, which was manifested by an increase in the level of CRP. Pharmacological correction of BS with HAES-LX-5 % and LPS solutions equally inhibited the development of endotoxicosis from the 3rd to the 7th day, which was accompanied by significant (p<0.05) decrease in the level of MWM by 36.2 % and 42.5 %, respectively, after administration of HAES-LX-5 % and by 32.9 % and 38.8 % after administration of LPS relative to control pathology. The use of solutions of HAES-LX-5 % and LPS inhibited the development of inflammation from the 3rd to the 7th day, which was accompanied by a significant (p<0.05) decrease in the level of CRP by 30.7 % and 35.0 % for HAES-LX-5 %, by 29.4 % and 32.9 % for LPS compared to control.
Conclusions. It has been experimentally shown in the model of BS that solutions HAES-LX-5 % and LPS show anti-inflammatory activity and reduce the level of endogenous intoxication, inhibiting the development of systemic stress.
Application of sorbitol-based infusion preparation for protein-protecting effect in surgery patients with middle breast cancer
Authors: Prymak S.V. , Dzis B.R. , Dzis R.P. , Novak V.L. , Dzisiv M.P. , Karpovich Ye.P. , Chaban V.Ye. , Ivasyk V.V. 
Published: October 2020

Objective. To study the energy effect of infusions of the drug Sorbilact in the body of operated patients with cancer of the middle thoracic esophagus.
Materials and methods. Clinical use of the drug Sorbilact was performed in 30 operated patients with cancer of the middle thoracic esophagus (the main group). Sorbilact was administered intravenously immediately after surgery, drip at a rate of 30 drops per minute for 5 days at a dose of 800 ml per day. Plasma urea concentration was determined before infusions on the 1st day after surgery, and on days 2, 3, 5 after Sorbilact infusions. The control group – 25 operated patients – was administered 5 % glucose solution at a dose of 800.0 ml.
Results and discussion. In the first days after surgery in patients with cancer of the middle thoracic esophagus an increase in the concentration of urea in blood plasma was revealed. In the main group of operated patients after resection of the middle thoracic esophagus in repeated studies on the 2nd, 3rd, 5th day after infusions a significant decrease in the concentration of urea in blood plasma was showed. It indicates that less endogenous protein is consumed for energy purposes, and the caloric needs of the operated body are covered by intensive absorption of Sorbilact, which reduces the catabolism of internal proteins, resulting in reduced nitrogen production, which is manifested in a decrease in the concentration of urea in blood plasma and its difference. In the control group of operated patients in repeated studies on the 2nd, 3rd, 5th day after infusions an increase in plasma urea was revealed, which indicates insufficient caloric energy expenditure of the operated organism.
Conclusions. Intravenous infusions of the drug Sorbilact according to the indicator of increment of urea in blood plasma in operated patients after resection of the middle thoracic esophagus in the early postoperative period show a pronounced energy effect.