bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue‐specific analysis of Fgf18 gene function in palate development
Authors: Yue Minghui , Lan Yu , Liu Han , Wu Zhaoming , Imamura Toru , Jiang Rulang 
Published: October 2020

AbstractBackgroundPrevious studies showed that mice lacking Fgf18 function had cleft palate defects and that the FGF18 locus was associated with cleft lip and palate in humans, but what specific roles Fgf18 plays during palatogenesis are unclear.ResultsWe show that Fgf18 exhibits regionally restricted expression in developing palatal shelves, mandible, and tongue, during palatal outgrowth and fusion in mouse embryos. Tissue‐specific inactivation of Fgf18 throughout neural crest‐derived craniofacial mesenchyme caused shortened mandible and reduction in ossification of the frontal, nasal, and anterior cranial base skeletal elements in Fgf18c/c;Wnt1‐Cre mutant mice. About 64% of Fgf18c/c;Wnt1‐Cre mice exhibited cleft palate. Whereas palatal shelf elevation was impaired in many Fgf18c/c;Wnt1‐Cre embryos, no significant difference in palatal cell proliferation was detected between Fgf18c/c;Wnt1‐Cre embryos and their control littermates. Embryonic maxillary explants from Fgf18c/c;Wnt1‐Cre embryos showed successful palatal shelf elevation and fusion in organ culture similar to the maxillary explants from control embryos. Furthermore, tissue‐specific inactivation of Fgf18 in the early palatal mesenchyme did not cause cleft palate.ConclusionThese results demonstrate a critical role for Fgf18 expression in the neural crest‐derived mesenchyme for the development of the mandible and multiple craniofacial bones but Fgf18 expression in the palatal mesenchyme is dispensable for palatogenesis.
Scientist Spotlights: Online assignments to promote inclusion in Ecology and Evolution
Authors: Brandt Samantha , Cotner Sehoya , Koth Zoe , McGaugh Suzanne 
Published: October 2020

AbstractScientific disciplines face large diversity challenges, with the fields of ecology and evolution being among the most homogeneous—specifically with respect to race and ethnicity. These problems have been recently compounded by large‐scale racial unrest, highlighting some of the underlying disparities that have led to these diversity challenges, and a global pandemic, which, by moving instruction online, has created new challenges for inclusive teaching. Among the inclusive‐teaching techniques that can be implemented during remote instruction are Scientist Spotlights—role‐model interventions that use available online materials to highlight the work of scientists representing multiple axes of diversity. We report here on the implementation of Scientist Spotlights in two courses, both of which emphasize ecology and evolution. We conclude with sample resources and suggestions for adopters.
Unaltered soil microbial community composition, but decreased metabolic activity in a semiarid grassland after two years of passive experimental warming
Authors: Fang Chao , Ke Wenbin , Campioli Matteo , Pei Jiuying , Yuan Ziqiang , Song Xin , Ye Jian‐Sheng , Li Fengmin , Janssens Ivan A. 
Published: October 2020

AbstractSoil microbial communities regulate soil carbon feedbacks to climate warming through microbial respiration (i.e., metabolic rate). A thorough understanding of the responses of composition, biomass, and metabolic rate of soil microbial community to warming is crucial to predict soil carbon stocks in a future warmer climate. Therefore, we conducted a field manipulative experiment in a semiarid grassland on the Loess Plateau of China to evaluate the responses of the soil microbial community to increased temperature from April 2015 to December 2017. Soil temperature was 2.0°C higher relative to the ambient when open‐top chambers (OTCs) were used. Warming did not affect microbial biomass or the composition of microbial functional groups. However, warming significantly decreased microbial respiration, directly resulting from soil pH decrease driven by the comediation of aboveground biomass increase, inorganic nitrogen increase, and moisture decrease. These findings highlight that the soil microbial community structure of semiarid grasslands resisted the short‐term warming by 2°C, although its metabolic rate declined.
Overexpression of endothelial β3‐adrenergic receptor induces diastolic dysfunction in rats
Authors: Dhot Justine , Ferron Marine , Prat Valentine , Persello Antoine , Roul David , Stévant David , Guijarro Damien , Piriou Nicolas , Aillerie Virginie , Erraud Angélique , Toumaniantz Gilles , Erfanian Morteza , Tesse Angela , Grabherr Amandine , Tesson Laurent , Menoret Séverine , Anegon Ignacio , Trochu Jean‐Noël , Steenman Marja , De Waard Michel , Rozec Bertrand , Lauzier Benjamin , Gauthier Chantal 
Published: October 2020

AbstractAimsDiastolic dysfunction is common in cardiovascular diseases, particularly in the case of heart failure with preserved ejection fraction. The challenge is to develop adequate animal models to envision human therapies in the future. It has been hypothesized that this diastolic dysfunction is linked to alterations in the nitric oxide (•NO) pathway. To investigate this issue further, we investigated the cardiac functions of a transgenic rat model (Tgβ3) that overexpresses the human β3‐adrenoceptor (hβ3‐AR) in the endothelium with the underlying rationale that the •NO pathway should be stimulated in the endothelium.Methods and resultsTransgenic rats (Tgβ3) that express hβ3‐AR under the control of intercellular adhesion molecule 2 promoter were developed for a specific expression in endothelial cells. Transcriptomic analyses were performed on left ventricular tissue from 45‐week‐old rats. Among all altered genes, we focus on •NO synthase expression and endothelial function with arterial reactivity and evaluation of •NO and O2•− production. Cardiac function was characterized by echocardiography, invasive haemodynamic studies, and working heart studies. Transcriptome analyses illustrate that several key genes are regulated by the hβ3‐AR overexpression. Overexpression of hβ3‐AR leads to a reduction of Nos3 mRNA expression (−72%; P < 0.05) associated with a decrease in protein expression (−19%; P < 0.05). Concentration‐dependent vasodilation to isoproterenol was significantly reduced in Tgβ3 aorta (−10%; P < 0.05), while •NO and O2•− production was increased. In the same time, Tgβ3 rats display progressively increasing diastolic dysfunction with age, as shown by an increase in the E/A filing ratio [1.15 ± 0.01 (wild type, WT) vs. 1.33 ± 0.04 (Tgβ3); P < 0.05] and in left ventricular end‐diastolic pressure [5.57 ± 1.23 mmHg (WT) vs. 11.68 ± 1.11 mmHg (Tgβ3); P < 0.05]. In isolated working hearts, diastolic stress using increasing preload levels led to a 20% decrease in aortic flow [55.4 ± 1.9 mL/min (WT) vs. 45.8 ± 2.5 mL/min (Tgβ3); P < 0.05].ConclusionsThe Tgβ3 rat model displays the expected increase in •NO production upon ageing and develops diastolic dysfunction. These findings provide a further link between endothelial and cardiac dysfunction. This rat model should be valuable for future preclinical evaluation of candidate drugs aimed at correcting diastolic dysfunction.
A novel procedure combining computational fluid dynamics and evolutionary approach to minimize parasitic power loss in air cooling of Li‐ion battery for thermal management system design
Authors: Jishnu A.K. , Garg Akhil , Shaosen Su , Su Yan , Panigrahi Bijaya Ketan 
Published: October 2020

AbstractAir‐cooling‐based battery thermal management system (BTMS) is a research hotspot for electric vehicles because of lower cost and simpler design. Past research works have immensely concentrated on the enhancement of heat removal from Li‐ion battery, but the minimum consideration has been given to minimize the parasitic power. In this paper, a novel procedure is proposed to predict the operating parameters (inlet velocity, working time of fan, and range of heat generation rates) of air‐cooling design for minimizing parasitic power and ensuring the battery temperature do not exceed the upper threshold limit simultaneously. Based on findings via computational fluid dynamics analysis, an empirical model of air‐cooling BTMS is further developed using an evolutionary approach of model selection criteria approximated genetic programming (MSC‐GP). The model is then optimized to determine operating parameters of air cooling which causes minimum parasitic power while keeping the average temperature of battery cells within the limit. Further, sensitivity analysis and parameter interaction (2D and 3D) analysis is also performed to study the effect and identify the contribution of various operating parameters on parasitic power. Operating time of fan has 49% influence on final temperature while inlet velocity has 36% influence only. However parasitic power is more sensitive to inlet velocity (77%) while operating time has 23% influence only. Finally, the optimal values of operating parameters for various heat generation rate per cell (function of discharge rate) are obtained. The optimized parasitic power was observed to be nonlinearly increasing with heat generation rate. Operating time of fan has 49% influence on final temperature while inlet velocity has 36% influence only. However, parasitic power is more sensitive to inlet velocity (77%) while operating time has 23% influence only.
Leaf essential oil from Ivorian Isolona dewevrei (Annonaceae): Chemical composition and structure elucidation of four new natural sesquiterpenes
Authors: Kambiré Didjour Albert , Boti Jean Brice , Ouattara Zana Adama , Yapi Thierry Acafou , Bighelli Ange , Tomi Félix , Casanova Joseph 
Published: October 2020

AbstractThis work is a contribution to the characterization of aromatic and medicinal plants from Côte d’Ivoire. To date, no phytochemical investigation was reported on Isolona dewevrei. Thus, the aim of this study was to investigate for the first time, the chemical composition of the leaf essential oil from I dewevrei. Two essential oil samples (S1, S2) were analysed by combination of chromatographic [GC(FID) and GC(RI)] and spectroscopic [MS, 13C‐NMR] techniques. As several compounds remained unidentified, particularly in sample S1, this oil was fractionated on silica gel column, leading to the isolation and structural elucidation of four new natural compounds by QTOF‐MS, 1D and 2D‐NMR analyses. These new natural sesquiterpenes were identified as (5αH,10βMe)‐6,12‐oxido‐elema‐1,3,6,11(12)‐tetraene, 6,12‐oxido‐germacra‐1(10),4,6,11(12)‐tetraene, (1βH,5βH)‐6,12‐oxido‐guaia‐6,10(14),11(12)‐trien‐4α‐ol and germacra‐1(10),4,7(11)‐trien‐6,12‐γ‐lactone. Finally, sixty‐eight constituents were identified in both investigated essential oil samples. They accounted for 96.1 and 97.3%, respectively, of the whole chemical composition of S1 and S2. Leaf essential oil from Idewevrei is very rich in sesquiterpenes. Indeed, its majority compounds were germacrene B (20.8 and 24.8%), (5αH,10βMe)‐6,12‐oxido‐elema‐1,3,6,11(12)‐tetraene (10.3 and 0.3%, new compound), germacrene D (7.5 and 17.8%), (Z)‐β‐ocimene (7.8 and 9.7%),γ‐elemene (6.9 and 7.5%) and (E)‐β‐caryophyllene (6.8 and 3.5%). The contents of thermolabile components were assessed by combination of GC(FID) and 13C‐NMR.
Crude Oil Price Fluctuation Analysis Under Considering Emergency and Network Search Data
Authors: Dai Wan‐qiang , Pan Wei , Shi Yongdong , Hu Cheng , Pan Wulin , Huang Ge 
Published: October 2020

AbstractWith the rapid development of the global economy, crude oil is becoming more and more prominent in terms of national stability. However, oil prices dramatically fluctuate during emergencies. Meanwhile, network search data have been widely used for prediction during the era of big data. Herein, a suggestion is introduced for improving the traditional case analysis. An autoregressive distributed lag model is established, considering emergency and network search data. Moreover, a network attention index of specific emergencies is used to explain fluctuations of the oil price and the influence of this attention is analyzed. Results show: 1) major emergencies have a significant short‐term impact on the international oil market and a remarkable influence on the cumulative abnormal return of an event window, and 2) market attention can aggravate fluctuations of oil prices. It is found that the individual network attention paid to each of four emergencies has a significant impact on oil prices. The network attention related to Hurricane Katrina and the Libyan war has positive effects on oil prices. However, the effects of network attention paid to the subprime crisis and the Mexico oil spill of 2010 are negative. The attention paid to the subprime crisis has both the greatest and the longest lasting impact.
HR ambidexterity and absorptive capacities: A paradox‐based approach to HRM capabilities and practice adoption in MNC subsidiaries
Authors: Beletskiy Anton , Fey Carl F. 
Published: October 2020

AbstractThis article examines the relationship between the capabilities of HR departments and the level of adoption of corporate HRM practices in MNC subsidiaries. To explain this relationship, we leverage paradox theorizing, still rare but gaining increasing attention in HRM research, and integrate the studies of practice transfer, organizational ambidexterity, and absorptive capacity. First, we establish the conceptual linkages between the implementation and internalization dimensions of practice adoption and the potential and realized absorptive capacities of HR departments. Second, we re‐define the operational and strategic activities of HR departments in terms of the learning paradox of exploitation and exploration. Third, we introduce the concept of HR ambidexterity to describe HR departments that possess high levels of capabilities in both operational (exploitative) and strategic (explorative) task‐domains. Finally, we hypothesize that ambidextrous HR departments are more adept at adopting corporate HRM practices. An analysis of the survey data from 105 foreign subsidiaries of 12 MNCs supports this single hypothesis. The main contribution of this research is in leveraging paradox theorizing to explain the nature of HRM capabilities and their role in the adoption of HRM practices.
Freeze–thaw processes degrade post‐fire water repellency in wet soils
Authors: Rakhmatulina Ekaterina , Thompson Sally 
Published: October 2020

AbstractWildfires are a cause of soil water repellency (hydrophobicity), which reduces infiltration whilst increasing erosion and flooding from post‐fire rainfall. Post‐fire soil water repellency degrades over time, often in response to repeated wetting and drying of the soil. However, in mountainous fire‐prone forests such as those in the Western USA, the fire season often terminates in a cold and wet winter, during which soils not only wet and dry, but also freeze and thaw. Little is known about the effect of repeated freezing and thawing of soil on the breakdown of post‐fire hydrophobicity. This study characterized the changes in hydrophobicity of Sierra Nevada mountain soils exposed to different combinations of wet–dry and freeze–thaw cycling. Following each cycle, hydrophobicity was measured using the Molarity of Ethanol test. Hydrophobicity declined similarly across all experiments that included a wetting cycle. Repeated freezing and thawing of dry soil did not degrade soil water repellency, but freeze–thaw cycles decreased hydrophobicity in wet soils. Total soil organic matter content was not different between soils of contrasting hydrophobicity. Macroscopic changes such as fissures and cracks were observed to form as soil hydrophobicity decayed. Microscopic changes revealed by scanning electron microscope imagery suggest different levels of soil aggregation occurred in samples with distinct hydrophobicities, although the size of aggregates was not clearly correlated to the change in water repellency due to wet–dry and freeze–thaw cycling. A 9‐year climate and soil moisture record from Providence Critical Zone Observatory was combined with the laboratory results to estimate that hydrophobicity would persist an average of 144 days post‐fire at this well‐characterized, typical mid‐elevation Sierra Nevada site. Most of the breakdown in soil water repellency (79%) under these climate conditions would be attributable to freeze–thaw cycling, underscoring the importance of this process in soil recovery from fire in the Sierra Nevada.
Thyroid and androgen receptor signaling are antagonized by μ‐Crystallin in prostate cancer
Authors: Aksoy Osman , Pencik Jan , Hartenbach Markus , Moazzami Ali A. , Schlederer Michaela , Balber Theresa , Varady Adam , Philippe Cecile , Baltzer Pascal A. , Mazumder Bismoy , Whitchurch Jonathan B. , Roberts Christopher J. , Haitel Andrea , Herac Merima , Susani Martin , Mitterhauser Markus , Marculescu Rodrig , Stangl‐Kremser Judith , Hassler Melanie R. , Kramer Gero , Shariat Shahrokh F. , Turner Suzanne D. , Tichy Boris , Oppelt Jan , Pospisilova Sarka , Hartenbach Sabrina , Tangermann Simone , Egger Gerda , Neubauer Heidi A. , Moriggl Richard , Culig Zoran , Greiner Georg , Hoermann Gregor , Hacker Marcus , Heery David M. , Merkel Olaf , Kenner Lukas 
Published: October 2020

AbstractAndrogen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3′‐triiodo‐L‐thyronine (T3) are involved in the progression of PCa. Epidemiologic evidences show a higher incidence of PCa in men with elevated thyroid hormone levels. The thyroid hormone binding protein μ‐Crystallin (CRYM) mediates intracellular thyroid hormone action by sequestering T3 and blocks its binding to cognate receptors (TRα/TRβ) in target tissues. We show in our study that low CRYM expression levels in PCa patients are associated with early biochemical recurrence and poor prognosis. Moreover, we found a disease stage‐specific expression of CRYM in PCa. CRYM counteracted thyroid and androgen signaling and blocked intracellular choline uptake. CRYM inversely correlated with [18F]fluoromethylcholine (FMC) levels in positron emission tomography/magnetic resonance imaging of PCa patients. Our data suggest CRYM as a novel antagonist of T3‐ and androgen‐mediated signaling in PCa. The role of CRYM could therefore be an essential control mechanism for the prevention of aggressive PCa growth.
The Feldstein–Horioka hypothesis for African countries: Evidence from recent panel error‐correction modelling
Authors: Murthy Vasudeva N.R. , Ketenci Natalya 
Published: October 2020

AbstractThis paper, by applying the recent panel data error‐correction modelling developed by Gengenbach et al., Panel error correction testing with global stochastic trends, 2008 University of Maastricht, Working Paper, RM/08/051:1–51 and Gengenbach et al., Journal of Applied Econometrics, 2016, 31, 982–1004 tests the validity of the Feldstein–Horioka puzzle (1980) in a panel of 27 African countries for the period 1965–2015. Unlike the existing studies in the literature, this paper, for the first time, addresses several important panel data econometric issues such as slope heterogeneity, cross‐section dependence, unobservable common factors, non‐stationarity and endogeneity that would yield inconsistent and biased estimates of the parameters of interest. Unlike the previous residual‐based error‐correction modelling that has low power, the Gengenbach et al., Panel error correction testing with global stochastic trends, 2008, University of Maastricht, Working Paper, RM/08/051:1–51 and Gengenbach et al., Journal of Applied Econometrics, 2016, 31, 982–1004 estimator explicitly considers structural dynamics in modelling a cointegrated panel that allows for the presence of non‐stationary unobserved common factors. As the GUW modelling depends on the Pesaran Common Correlated Effects Mean Group Estimator (CCEMG; 2006) and the Chudik and Pesaran Dynamic Common Correlated Effects Mean Group Estimator (DCCEMG; 2015), we report the results based on these estimators. The econometric exercises performed in the paper show that slope heterogeneity; cross‐section dependence and non‐stationarity are present in the panel data sample used in the estimation. Estimations yield a relatively low magnitude of the savings retention coefficient for the panel members included in the study with a negative error‐correction term that is statistically significant at the individual and panel levels. The empirical evidence rejects the presence of the Feldstein–Horioka puzzle in the panel of 27 African countries studied.
Assessment of fish scale biosorbent in the treatment of seafood processing plant wastewater
Authors: Subhashree Devasena S , Padmavathy P , Manimekalai D , Jeya Shakila R 
Published: October 2020

AbstractBACKGROUNDWastewater generated from seafood processing plants poses a serious threat to the draining environments. In addition, huge amount of fish scales are discarded as solid waste from seafood processing plants and fish markets. These biowastes can be used as biosorbent in the treatment of wastewaters. In the present work, waste fish scales were employed as biosorbent in order to explore the adsorption capacity of several pollutant parameters such as nutrients, ammonia, biological oxygen demand (BOD) and chemical oxygen demand (COD) in the treatment of seafood processing plant wastewater. The experiment was carried out as batch work under varying biosorbent dosage levels and contact times.RESULTSThe biosorbent treatment showed >70% removal of nitrite, phosphate and BOD. The ammonia and COD were significantly (P < 0.05) reduced with >95% removal at the end of treatment process. Based on the results, the treatment showed best adsorption at 90 min contact time with a biosorbent dosage of 1 g/100 mL in the removal of BOD, COD and ammonia. Other parameters showed maximum reduction at 180 min contact time. Experimental data fitted well with the Langmuir and Freundlich isotherm models (R2 values ranging between 0.84 and 0.99). All of the data were statistically tested using SPSS v25 software.CONCLUSIONThe results of the present study showed that waste fish scales can be effectively reused as biosorbent in the treatment of organic pollutants from seafood processing plant wastewater. © 2020 Society of Chemical Industry (SCI)