bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet-rich plasma another add-on treatment getting out of hand? How can clinicians preserve the best interest of their patients?
Authors: Urman Bulent , Boza Aysen , Balaban Basak 
Published: November 2019

AbstractAdd-on treatments in IVF are utilized to a great extent but without sufficient evidence showing their effectiveness. Since the offered treatments are usually costly and may be associated with yet unknown risks, this practice is not in the best interest of couples that may go to great lengths to conceive and have an offspring carrying their own genetic make-up. A recent addition to this armamentarium is the administration of platelet-rich plasma (PRP) in women with diminished ovarian reserve, implantation failures, and a thin endometrium. The only evidence for PRP comes from small scale and mostly before and after studies with clinically irrelevant end points. PRP has not been subjected to a rigorous clinical trial. It is a typical example of an add-on gaining widespread popularity based on biological plausibility and mind-bending theoretical presumptions. We should be extremely cautious prior to implementing PRP on a widescale and await the results of well-designed studies.
Technology Frontiers of Building-integrated Photovoltaics (BIPV): A Patent Co-citation Analysis
Authors: Zhong Botao , Hei Yongjian , Jiao Li , Luo Hanbin , Tang Junqing 
Published: November 2019

Abstract
Recently, greater research attention has focused on the application of solar power generation technology in building construction to reduce building energy consumption and encourage increased sustainable development. An emerging solar power generation technology is in the use of Building-integrated Photovoltaics (BIPVs), where photovoltaic materials are used to replace conventional building materials. In order to map the development of BIPV technology over time and explore technology paths, this study retrieved a total of 4914 patents dated from 1972 to 2016 from the Derwent Innovations Index patent database. This study applies patent co-citation analysis to map the patent co-citation network in three periods based on Ucinet tool. Evolutional path and three key technology frontiers were identified using Social Network Analysis (SNA) and text clustering. The results of this study provide an informed reference for future researchers in understanding the historical development of BIPV, as an emerging and important solar power generation technology in the built environment. At the same time, big data of patents are analyzed using SNA and text clustering, which overcomes the limitation of previous methods of frontiers study that have depended on expert opinion or peer review.
Risk of Severe Influenza Among Adults With Chronic Medical Conditions
Authors: Walker Tiffany A , Waite Ben , Thompson Mark G , McArthur Colin , Wong Conroy , Baker Michael G , Wood Tim , Haubrock Jennifer , Roberts Sally , Gross Diane K , Huang Q Sue , Newbern E Claire 
Published: November 2019

Abstract

Background
Severe influenza illness is presumed more common in adults with chronic medical conditions (CMCs), but evidence is sparse and often combined into broad CMC categories.

Methods
Residents (aged 18–80 years) of Central and South Auckland hospitalized for World Health Organization-defined severe acute respiratory illness (SARI) (2012–2015) underwent influenza virus polymerase chain reaction testing. The CMC statuses for Auckland residents were modeled using hospitalization International Classification of Diseases, Tenth Revision codes, pharmaceutical claims, and laboratory results. Population-level influenza rates in adults with congestive heart failure (CHF), coronary artery disease (CAD), cerebrovascular accidents (CVA), chronic obstructive pulmonary disease (COPD), asthma, diabetes mellitus (DM), and end-stage renal disease (ESRD) were calculated by Poisson regression stratified by age and adjusted for ethnicity.

Results
Among 891 276 adults, 2435 influenza-associated SARI hospitalizations occurred. Rates were significantly higher in those with CMCs compared with those without the respective CMC, except for older adults with DM or those aged &lt;65 years with CVA. The largest effects occurred with CHF (incidence rate ratio [IRR] range, 4.84–13.4 across age strata), ESRD (IRR range, 3.30–9.02), CAD (IRR range, 2.77–10.7), and COPD (IRR range, 5.89–8.78) and tapered with age.

Conclusions
Our findings support the increased risk of severe, laboratory-confirmed influenza disease among adults with specific CMCs compared with those without these conditions.
The Impact of Sorghum Growth Stage and Resistance on Life History of Sugarcane Aphids (Hemiptera: Aphididae)
Authors: Neupane Subin B , Kerns David L , Szczepaniec Adrianna 
Published: November 2019

Abstract
Recent invasion of a new haplotype of sugarcane aphid (Melanaphis sacchari Zehntner) resulted in severe outbreaks of the aphids in sorghum (Sorghum bicolor L. Moench [Poales: Poaceae]) across the United States. Previous research and field observations suggested that both sorghum resistance and growth stage were important to their population dynamics in the field and hence effective and timely management to minimize economic losses associated with this pest. To explore this, we designed greenhouse experiments to quantify fecundity, prereproductive period, and longevity of sugarcane aphids across several vegetative and reproductive growth stages of a resistant (DKS 37-07) and susceptible (M77GB52 and DKS 38–88) sorghum hybrids commonly used in sorghum production. We found significant effects of sorghum resistance and growth stage on several life history traits and demographics parameters of sugarcane aphids. We did not, however, note any significant interactive effects of resistance and phenology on any of the response variables. Sugarcane aphids exposed to the susceptible sorghum produced significantly more offspring, had significantly greater intrinsic and finite rates of increase, and significantly shorter population doubling time than the aphids feeding on resistant sorghum. On the other hand, the impact of sorghum growth stage had more variable effects on life history of sugarcane aphids that were most frequently evident at the late reproductive stages. These outcomes support our hypothesis that sorghum in late stages of growth tends to be a better host for sugarcane aphids and highlight the importance of sorghum growth stage to sugarcane aphid life history and population growth potential.
Strain-accumulation mechanisms in sands under isotropic stress
Authors: Sajeva A , Capaccioli S , Cheng H 
Published: November 2019

AbstractDetermining the pressure dependence of dynamic moduli in unconsolidated sediments is still an open problem in applied geophysics. This is because several petrophysical parameters affect the elastic response of the granular medium during compression. Effective medium theories based on the Hertz–Mindlin contact law estimate the effective moduli from petrophysical parameters. Among them, the Pride and Berryman model assumes that new contacts between grains are progressively created during compression. Furthermore, the gaps around rattlers are distributed following a power law with distance and the global strain can change either linearly or quadratically with the local strain. This identifies two types of strain accumulation. Quadratic strain accumulation is associated with grain rotation. We simplified this model by assuming a flat distribution of gaps around rattlers and we applied this simplified model to published ultrasonic measurements. By means of these measurements, we studied how the strain-accumulation mechanism affects the coordination number during isotropic compression. The coordination numbers were estimated by applying a DEM-based correction to the average-strain model. We observe that the majority of the experimental trends lay between the linear and the quadratic accumulation trends. Based on this result, we assume that the strain accumulation is a combination of the two mechanisms and we propose a formula to estimate the contribution of each mechanism. Furthermore, we note that, in the studied datasets, rotation affects larger grains (diameter approximately 500 μm) more than smaller grains (diameter approximately 100 μm). If further validated, this correlation could guide the determination of pressure trends for sands.
Variation in Morphology and Airborne Dispersal of the Urticating Apparatus of Ochrogaster lunifer (Lepidoptera: Notodontidae), an Australian Processionary Caterpillar, and Implications for Livestock and Humans
Authors: Perkins Lynda E , Cribb Bronwen W , Pagendam Dan E , Zalucki Myron P 
Published: November 2019

Abstract
True setae borne on the abdominal tergites of Ochrogaster lunifer Herrich-Schӓffer caterpillars are the agents of an irritating contact dermatitis, osteomyelitis, ophthalmia, and severe allergic reactions in humans, and are the cause of Equine Amnionitis and Fetal Loss in Australia. The setae are detached and readily dislodge from the integument whereby they disperse throughout the environment. To better understand the true setae of O. lunifer as agents of medical and veterinary concern, we studied their characteristics and distance dispersed. Whereas members of the European Thaumetopoeinae have been widely studied, their southern-hemisphere counterparts such as O. lunifer are not well known despite their harmfulness and known medical and veterinary importance. The caterpillar’s investment in true setae increased with age and size, and two distinct size classes co-occurred in setae fields. A previously undescribed morphological type of true seta was found on the first abdominal segment. All true setae were calculated to travel long distances in the air even under light breeze conditions. Our results show there is a high risk of exposure to airborne urticating setae within 100 m of elevated caterpillar activity, and a likely risk of exposure for some kilometers in the direction of the prevailing breeze. This information should be used to inform management strategies in areas where urticating processionary caterpillars are active, and especially during periods of an outbreak.
Subtype-Specific Breast Cancer Incidence Rates in Black versus White Men in the United States
Authors: Sung Hyuna , DeSantis Carol , Jemal Ahmedin 
Published: November 2019

Abstract
Compared with white women, black women have higher incidence rates for triple-negative breast cancer but lower rates for hormone receptor (HR)–positive cancers in the United States. Whether similar racial difference occurs in male breast cancer is unclear. We examined racial differences in incidence rates of breast cancer subtypes defined by HR and human epidermal growth factor receptor 2 (HER2) by sex using nationwide data from 2010 to 2016. Among men, rates were higher in blacks than whites for all subtypes, with the black-to-white incidence rate ratios of 1.41 (95% confidence interval [CI ]= 1.32 to 1.50) for HR+/HER-, 1.65 (95% CI = 1.40 to 1.93) for HR+/HER2+, 2.62 (95% CI = 1.48 to 4.43) for HR-/HER2+, and 2.27 (95% CI = 1.67 to 3.03) for triple-negative subtype. Conversely, among women, rates in blacks were 21% lower for HR+/HER2- and comparable for HR+/HER2+ but 29% and 93% higher for HR-/HER2+ and triple-negative subtypes, respectively. Future studies are needed to identify contributing factors to the dissimilar racial patterns in breast cancer subtype incidence between men and women.
An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients
Authors: Chau Nicole G , Ma Clement , Danga Kristina , Al-Sayegh Hasan , Nardi Valentina , Barrette Ryan , Lathan Christopher S , DuBois Steven G , Haddad Robert I , Shapiro Geoffrey I , Sallan Stephen E , Dhar Arindam , Nelson Jeanenne J , French Christopher A 
Published: November 2019

AbstractBackgroundNUT midline carcinoma, renamed NUT carcinoma (NC), is an aggressive squamous cancer defined by rearrangement of the NUTM1 gene. Although a subset of patients can be cured, for the majority of patients the prognosis is grim. We sought to classify patients into risk groups based on molecular and clinicopathologic factors at the time of diagnosis.MethodsClinicopathologic variables and survival outcomes were extracted for a total of 141 NC patients from the NUT midline carcinoma Registry using questionnaires and medical records. Translocation type was identified by molecular analyses. Survival tree regression analysis was performed to determine risk factors associated with overall survival (OS).ResultsFor 141 patients, the median age at diagnosis was 23.6 years. Fifty-one percent had thoracic origin compared with 49% nonthoracic sites (41% head and neck, 6% bone or soft tissue, 1% other). The median OS was 6.5 months (95% confidence interval [CI] = 5.8 to 9.1 months). Most patients had the BRD4-NUTM1 fusion (78%), followed by BRD3-NUTM1 (15%) and NSD3-NUTM1 (6%). Survival tree regression identified three statistically distinct risk groups among 124 patients classified by anatomical site and genetics: group A is nonthoracic primary, BRD3-, or NSD3-NUT (n = 12, median OS = 36.5 months, 95% CI = 12.5 to not reported months); group B is nonthoracic primary, BRD4-NUT (n = 45, median OS = 10 months, 95% CI = 7 to 14.6 months); and group C is thoracic primary (n = 67, median OS = 4.4 months, 95% CI = 3.5 to 5.6 months). Only groups A and B had long-term (≥3 years, n = 12) survivors.ConclusionsWe identify three risk groups defined by anatomic site and NUT fusion type. Nonthoracic primary with non-BRD4-NUT fusion confers the best prognosis, followed by nonthoracic primary with BRD4-NUT. Thoracic NC patients, regardless of the NUT fusion, have the worst survival.
Euclid-era cosmology for everyone: Neural net assisted MCMC sampling for the joint 3x2 likelihood
Authors: Manrique-Yus Andrea , Sellentin Elena 
Published: November 2019

Abstract
We develop a fully non-invasive use of machine learning in order to enable open research on Euclid-sized data sets. Our algorithm leaves complete control over theory and data analysis, unlike many black-box like uses of machine learning. Focusing on a ‘3x2 analysis’ which combines cosmic shear, galaxy clustering and tangential shear at a Euclid-like sky coverage, we arrange a total of 348000 data points into data matrices whose structure permits not only an easy prediction by neural nets, but it additionally permits the essential removal from the data of patterns which the neural nets could not ‘understand’. The latter provides an often lacking mechanism to control and debias the inference of physics. The theoretical backbone to our neural net training can be any conventional (deterministic) theory code, where we chose CLASS. After training, we infer the seven parameters of a wCDM cosmology by Monte Carlo Markov sampling posteriors at Euclid-like precision within a day. We publicly provide the neural nets which memorise and output all 3x2 power spectra at a Euclid-like sky coverage and redshift binning.
Projected velocity statistics of interstellar turbulence
Authors: Xu Siyao 
Published: November 2019

ABSTRACT
Velocity statistics is a direct probe of the dynamics of interstellar turbulence. Its observational measurements are very challenging due to the convolution between density and velocity and projection effects. We introduce the projected velocity structure function, which can be generally applied to statistical studies of both subsonic and supersonic turbulence in different interstellar phases. It recovers the turbulent velocity spectrum from the projected velocity field in different regimes, and when the thickness of a cloud is less than the driving scale of turbulence, it can also be used to determine the cloud thickness and the turbulence driving scale. By applying it to the existing core velocity dispersion measurements of the Taurus cloud, we find a transition from the Kolmogorov to the Burgers scaling of turbulent velocities with decreasing length-scales, corresponding to the large-scale solenoidal motions and small-scale compressive motions, respectively. The latter occupy a small fraction of the volume and can be selectively sampled by clusters of cores with the typical cluster size indicated by the transition scale.
Structure–fluorescence activation relationships of a large Stokes shift fluorogenic RNA aptamer
Authors: Steinmetzger Christian , Bessi Irene , Lenz Ann-Kathrin , Höbartner Claudia 
Published: November 2019

Abstract
The Chili RNA aptamer is a 52 nt long fluorogen-activating RNA aptamer (FLAP) that confers fluorescence to structurally diverse derivatives of fluorescent protein chromophores. A key feature of Chili is the formation of highly stable complexes with different ligands, which exhibit bright, highly Stokes-shifted fluorescence emission. In this work, we have analyzed the interactions between the Chili RNA and a family of conditionally fluorescent ligands using a variety of spectroscopic, calorimetric and biochemical techniques to reveal key structure–fluorescence activation relationships (SFARs). The ligands under investigation form two categories with emission maxima of ∼540 or ∼590 nm, respectively, and bind with affinities in the nanomolar to low-micromolar range. Isothermal titration calorimetry was used to elucidate the enthalpic and entropic contributions to binding affinity for a cationic ligand that is unique to the Chili aptamer. In addition to fluorescence activation, ligand binding was also observed by NMR spectroscopy, revealing characteristic signals for the formation of a G-quadruplex only upon ligand binding. These data shed light on the molecular features required and responsible for the large Stokes shift and the strong fluorescence enhancement of red and green emitting RNA–chromophore complexes.
Sharing DNA-binding information across structurally similar proteins enables accurate specificity determination
Authors: Wetzel Joshua L , Singh Mona 
Published: November 2019

Abstract
We are now in an era where protein–DNA interactions have been experimentally assayed for thousands of DNA-binding proteins. In order to infer DNA-binding specificities from these data, numerous sophisticated computational methods have been developed. These approaches typically infer DNA-binding specificities by considering interactions for each protein independently, ignoring related and potentially valuable interaction information across other proteins that bind DNA via the same structural domain. Here we introduce a framework for inferring DNA-binding specificities by considering protein–DNA interactions for entire groups of structurally similar proteins simultaneously. We devise both constrained optimization and label propagation algorithms for this task, each balancing observations at the individual protein level against dataset-wide consistency of interaction preferences. We test our approaches on two large, independent Cys2His2 zinc finger protein–DNA interaction datasets. We demonstrate that jointly inferring specificities within each dataset individually dramatically improves accuracy, leading to increased agreement both between these two datasets and with a fixed external standard. Overall, our results suggest that sharing protein–DNA interaction information across structurally similar proteins is a powerful means to enable accurate inference of DNA-binding specificities.
Extraneural metastatic anaplastic ependymoma: a systematic review and a report of metastases to bilateral parotid glands
Authors: Umbach Gray , El Ahmadieh Tarek Y , Plitt Aaron R , Aoun Salah G , Neeley Om J , Lyon Kristopher A , Fonkem Ekokobe , Raisanen Jack M , Bishop Justin A , Wardak Zabi , Patel Toral R , Myers Larry , Mickey Bruce E 
Published: November 2019

Abstract

Background
Anaplastic ependymoma with extraneural metastases is associated with a poor clinical outcome. Metastatic spread to the parotid gland is a rare clinical entity that requires multidisciplinary intervention. Herein, we present a systematic review of anaplastic ependymoma with extraneural metastases and report on a case with metastases to both parotid glands.

Methods
Electronic databases were searched from their inception to February 2019. Inclusion criteria included reports of anaplastic ependymoma with extraneural metastasis. Studies were excluded if the tumor grade was not reported. A case illustration is provided.

Results
The search yielded 15 cases of anaplastic ependymoma with extraneural metastases, including the present case. Mean age at diagnosis was 15 years. The initial tumor location was predominantly supratentorial (93.3%). All cases demonstrated leptomeningeal seeding before extraneural metastasis. Mean survival from initial diagnosis was 4.5 years. Metastasis to the parotid gland occurred in 2 cases, including the present case. We present a 17-year-old female patient who underwent gross total resection of a supratentorial, paraventricular anaplastic ependymoma followed by adjuvant external beam radiation therapy. The patient developed recurrent leptomeningeal seeding, treated with Gamma Knife radiosurgery over a 5-year period. She returned with a parotid mass and cervical lymphadenopathy and underwent parotidectomy and modified radical neck dissection. She continued to experience recurrences, including the left parotid gland, and was ultimately placed in hospice care.

Conclusions
Anaplastic ependymoma with extraneural metastasis is rare. A combination of repeated surgical resection, radiation therapy, and chemotherapy can be used to manage recurrent and metastatic disease, but outcomes remain poor.
Temporoinsular Glioma Resection under Awake Mapping: 2-Dimensional Operative Video
Authors: Gong Fangyuan , Hameed N U Farrukh , Li Zeyang , Kudulaiti Nijiati , Zhang Jie , Wu Jinsong 
Published: November 2019

Abstract
Temporoinsular gliomas are frequently large-sized tumors that require meticulous planning to ensure maximum surgical resection and minimal neurologic deficits in patients. Here, we demonstrate our technique encompassing multi-modal imaging guidance and awake brain mapping which enables maximum safe resection of such tumors.
The patient, a 39-yr-old man, presented with depression and memory loss for 18 mo. Preoperative magnetic resonance imaging (MRI; MAGNETOM Verio, Siemens) revealed a nonenhancing lesion in the left dominant temporoinsular lobe. Three-dimensional magnetic resonance spectroscopy was used to analyze the choline/N-acetyl-aspartate index which suggested a low-grade glioma diagnosis. Informed patient consent was obtained.
After craniotomy, the mouth motor, speech arrest, and word generation areas were mapped via direct cortical stimulation under awake mapping. A strip electrode was placed across the precentral gyrus for continuous motor evoked potential monitoring. Cortical incisions were made in nonfunctional cortical areas and tumor was resected in the temporal lobe. Following this, tumor at the inferior insular zone was carefully debunked with Cavitron Ultrasonic Surgical Aspirator (Integra Lifescience) also through the temporal window. The hippocampus was preserved since it was not invaded by tumor. Subcortical mapping combined with Diffuse Tensor Imaging tractography-based navigation (Medtronic lnc.) was performed to localize the motor and language pathways. Intraoperative MRI evaluation showed tumor resection extent of 95%. Pathological and molecular analysis revealed a diagnosis of Grade II IDH-mutant oligodendroglioma. After surgery the patient was administered chemotherapy (Temozolomide). He recovered without language or motor deficits.