bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women
Authors: Passos Maria Elizabeth Pereira , Borges Leandro , dos Santos-Oliveira Laiane Cristina , Alecrim-Zeza Amanda Lins , Lobato Tiago Bertola , de Oliveira Heloisa Helena , Santos Cesar Miguel Momesso , Diniz Vinicius Leonardo Sousa , Iser-Bem Patrícia Nancy , Manoel Richelieau , Murata Gilson Masahiro , Hirabara Sandro Massao , Curi Rui , Pithon-Curi Tania Cristina , Hatanaka Elaine , Gorjao Renata 
Published: December 2020

AbstractThis study aimed to investigate the impact of a 16-week dance-based aerobic exercise program on lymphocyte function in healthy and type 2 diabetes mellitus (T2DM) women. We enrolled 23 women: 11 with T2DM and 12 non-diabetic controls. Initially, we performed anthropometry and body composition measurements, afterwards, plasma levels of C-reactive protein, lipids, and glucose were determined. We used flow cytometry to measure the CD25 and CD28 expression in circulating lymphocytes, T-regulatory (Treg) cell percentage, lymphocyte proliferation, and cytokines released by cultured lymphocytes. The T2DM group had a lower proportion of CD28+ cells and a higher percentage of Treg lymphocytes and proliferative capacity at the baseline compared with the control group. After 16 weeks of the program, differences in lymphocytes between the T2DM and the control groups disappeared. The dance program promoted IL-10 increase in both groups. We found decreased IL-4, IL-2, and IL-6 secretion in lymphocytes from the control group and increased IL-17 secretion and IL-10/IL-17 ratio in the T2DM group after the program. The program promoted marked changes in lymphocytes in diabetic women, leading to a balance between the different profiles.
Prävention bei chronisch entzündlichen Darmerkrankungen
Authors: Tischendorf Stefanie , Hatting Maximilian 
Published: December 2020

ZUSAMMENFASSUNGPatienten mit chronisch entzündlichen Erkrankungen (CED) wie Morbus Crohn und Colitis ulcerosa haben spezielle Bedürfnisse im Bereich Vorsorge und Prävention. Grunderkrankung und Therapie können in verschiedenen Bereichen zu erhöhter Morbidität führen. Blutbildveränderungen durch chronischen Blutverlust und Substratmangel oder Eisenverwertungsstörungen sind häufig. Steroidtherapie und Malnutrition können zu Osteopenie und Osteoporose führen. Hier sind CED-Patienten, insbesondere im Alter, gefährdet. Das Erkennen von Mangelzuständen und die Optimierung der Therapie sind entscheidend, um hier präventiv tätig zu werden. Gleiches gilt für das Erkennen von Impflücken und die richtige Risikostratifizierung der häufig immunsupprimierten Patienten. Zuletzt ist auch die Tumorvorsorge von Bedeutung, da sowohl durch die Grunderkrankung als auch durch die Therapie ein erhöhtes Malignomrisiko bestehen kann.
Mit Morbus Crohn und Colitis ulcerosa sicher durch die Schwangerschaft
Authors: Wiestler Miriam , Seidler Ursula 
Published: December 2020

ZUSAMMENFASSUNGAufgrund des mehrheitlich jungen Erkrankungsalters befinden sich Patienten mit chronisch entzündlichen Darmerkrankungen (CED) oft in der Phase der Kinderplanung. Auch wenn die Rate an Kinderlosigkeit unter CED-Patienten im Vergleich zur Normalbevölkerung erhöht ist, ist die Fertilität nur im Erkrankungsschub oder nach besonderen Situationen wie bspw. Beckenoperationen eingeschränkt. Dies verdeutlicht, dass CED-Patienten sich eher aufgrund ihrer Erkrankung einer freiwilligen Kinderlosigkeit oder -armut unterwerfen.Das Erreichen einer stabilen Remission vor der Konzeption und während der gesamten Schwangerschaft ist der wichtigste Faktor zur Komplikationsminimierung während der Schwangerschaft von CED-Patientinnen. In stabiler Remission haben Patientinnen im Vergleich zur Normalbevölkerung kein erhöhtes Risiko für Schwangerschaftskomplikationen. Es ist daher essenziell, schon frühzeitig die Schwangerschaftsplanung mit den Patientinnen zur diskutieren und bereits vor Konzeption eine stabile Remission zu erzielen. Hierzu können die meisten Medikamente zur Behandlung von CED während der Schwangerschaft und Stillzeit fortgesetzt werden. Methotrexat soll mindestens 3–6 Monate vor Konzeption aufgrund seiner teratogenen Wirkung abgesetzt werden. Bei TNF-alpha-Antikörpern sollte die diaplazentare Transmission ab der 20./24. Schwangerschaftswoche bedacht werden. Der Schlüssel zu einer sicheren Schwangerschaft ist die kontinuierliche Überwachung und Kontrolle der CED-Inflammationsaktivität.
Medikamentöse Therapie der chronisch entzündlichen Darmerkrankungen (CED)
Authors: Morgenstern Julia , Streetz Konrad 
Published: December 2020

ZUSAMMENFASSUNGDie Therapie der chronisch entzündlichen Darmerkrankungen (CED) unterliegt insbesondere in den letzten 2 Jahrzehnten einem deutlichen Wandel. Steroide nehmen in der Behandlung der akuten Entzündung sowohl beim Morbus Crohn als auch der Colitis ulcerosa zwar immer noch einen wichtigen Platz ein, stellen jedoch keine langfristige Therapieoption dar.Eine Vielzahl neuer galenischer Formulierungen bekannter Medikamente, der Einsatz von Biologika und neuer kleinmolekularer Inhibitoren (mit weiteren Wirkstoffen in der Entwicklung) erweitern die therapeutischen Möglichkeiten erfreulicherweise und führen damit zu einer Verbesserung der Lebensqualität der Patienten.Die große Herausforderung für den Behandler ist neben der Wahl des geeigneten Medikaments zum richtigen Zeitpunkt, zunehmend auch ein zielgerichtetes Management der Therapie. Hierzu gehören Dosisanpassungen der Therapeutika, geeignete Ko-Medikationen und ein genaues Monitoring des Krankheitsverlaufs.
Medikamente in der Pipeline
Authors: Stallmach Andreas , Schmidt Carsten 
Published: December 2020

ZUSAMMENFASSUNGDurch die Einführung der TNF-Antikörper in die Therapie der chronisch entzündlichen Darmerkrankungen (CED) haben sich die Behandlungsmöglichkeiten revolutioniert. Trotz großer Fortschritte mit der Verfügbarkeit weiterer Antikörper gegen Zytokine oder Zelladhäsionsmoleküle oder Inhibitoren der Januskinasen sind nicht alle Probleme gelöst. Das primäre Nichtansprechen oder Wirkungsverluste zum einen sowie Kontraindikationen, Unverträglichkeiten und Nebenwirkungen zum anderen begründen die Notwendigkeit für die Entwicklung neuer Substanzen; der aktuelle Stand soll hier dargestellt werden. Neben den Wirkungsnachweisen dieser neuen Therapeutika sind direkte Vergleiche zu etablierten Substanzen, sogenannte head-to-head-Studien zu fordern, um der behandelnden Ärztin oder dem Arzt die notwendigen Informationen für einen zielgerichteten und wirkungsvollen Einsatz im Sinne der Patienten zu geben.
CH-Diazomethane Sulfonamides Generated in Situ for Intramolecular [3+2] Cycloaddition of Alkynes: An Entry into Novel Pyrazole-Fused Five-Membered Sultams
Authors: Dar’in Dmitry , Krasavin Mikhail , Bubyrev Andrey , Kantin Grigory 
Published: December 2020

AbstractPreviously reported CH-diazomethane sulfonamides carrying various propargylic groups are generated in situ from their acetyl precursors. Without purification, these compounds undergo a slow, albeit clean and efficient, intramolecular [3+2] cycloaddition to give pyrazole-fused five-membered sultams. The latter are the first analogues of medicinally important (hetero)arene-fused five-membered sultams containing a five-membered nitrogenous heterocycle. The newly introduced scaffold can be further elaborated into N-arylated derivatives using the Chan–Evans–Lam protocol. The resulting compounds incorporate more than one privileged moiety and are highly suitable for interrogation of protein targets via biological screening.
Nickel-Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-H for the Synthesis of β,γ-Unsaturated Carboxylic Acids
Authors: Kimura Masanari , Luo Ying , Chan Bun , Fukuda Tsutomu , Onodera Gen 
Published: December 2020

AbstractConjugated dienes underwent Ni-catalyst-promoted 1,2-hydrocarboxylation in a 1:1 ratio with carbon dioxide under atmospheric pressure in the presence of diisobutylaluminum hydride (DIBAL-H) to give the corresponding β,γ-unsaturated carboxylic acids, without dimerization or oligomerization of the conjugated diene.
Synthesis of sp3-Enriched β-Fluoro Sulfonyl Chlorides
Authors: Grygorenko Oleksandr O. , Gurbanov Rustam , Sokolov Andriy , Golovach Sergey , Melnykov Kostiantyn , Dobrydnev Alexey V. 
Published: December 2020

AbstractA three-step approach to the synthesis of sp3-enriched β-fluoro sulfonyl chlorides starting from alkenes is reported. The method was successfully applied to a wide range of acyclic and cyclic substrates, bearing either an exocyclic or an endocyclic double bond. The procedure worked with a wide range of substrates and tolerated a number of functional and protecting groups. Moreover, the target cyclic compounds were obtained as single cis diastereomers on a multigram scale. The title compounds are promising building blocks for drug discovery that can be used to obtain sp3-enriched β-fluoro and α,β-unsaturated sulfonamides.
Homoeopathic Treatment of Atopic Dermatitis in an Infant: A Case Report
Authors: Bhattacharjee Baidurjya , Pachuau Vanlalfakawmi 
Published: December 2020

AbstractAtopic dermatitis (AD) is a common dermatological disorder in children, which is chronic and of a relapsing nature. It is very common in children, with a fair chance of lifetime prevalence of the disease. The following case is of a child 5 months of age who was suffering from AD since 2 months of age. After the first prescription, complaints were much improved. Following that, the child was treated with complex homoeopathic medicines by another physician, which aggravated the condition. Following stoppage of medicines due to an aggravation, a second remedy was thereafter prescribed that provided long-term relief to the patient.
Gut Microbiota: In Dynamics of Life and Homoeopathy
Authors: Suchiang Eiphrangdaka L. , Kumar Deepak , Yeasmin Shabana , Singh Monisha , Michael James , Pal Gautam 
Published: December 2020

AbstractThe Human Microbiome Project (HMP) launched in 2008 by the National Institute of Health (NIH) fascinated microbiologists with discoveries of micro-organisms inside and outside of human beings. Their correlation with health and disease brings a new insight to preventive and therapeutic measures. At present, focus is more on the micro-organisms residing in the gut and various factors capable of altering their composition. The conclusion made by Dr. Edward Bach regarding the ability of homoeopathic potencies to alter bowel flora and its relation with chronic diseases was investigated and experimented way back. The present review attempts to correlate gut microbiota with the art and science of homoeopathy.
Concept of Mental Health and Disease for Practical Implementation: A Case-Based Teaching for Undergraduate Students Part II: Abnormal Psychology and Psychiatry and the Homoeopathic approach
Authors: Yadav Rajesh Ramkunwar 
Published: December 2020

Abstract
Background India faces a significant gap in the prevalence of mental illness and the availability of effective mental health care. A significant factor is inadequate teaching/training of the subject at the undergraduate level rendering physicians incapable to deliver homoeopathic care to the large number of mentally distressed which needs it. This is in spite of our science having an immense potential to benefit these patients. Part I of this series explored the impact of cased-based teaching on acquainting the students in the principles of basic and applied psychology. The current study builds on this experience.
Aim The aim of this study was to teach the basic concepts of abnormal psychology and psychiatry and the homoeopathic approach to homoeopathic undergraduate students based on case-based presentations
Methodology Plan of teaching abnormal psychology and psychiatry to undergraduate students with a case-based approach integrated with homoeopathic principles was formulated by the Psychiatric Department of Dr. M. L. Dhawale Homoeopathic Institute (MLDMHI), Palghar, Maharashtra, India. PG students prepared topics with the help of a lesson plan template guided by the faculty. Peer evaluation along with student feedback helped to gauge the impact of the lectures and to design improvements.
Results Eleven topics, one each week, covered the assigned portion for basic abnormal psychology and psychiatry. Reports of minimum 30 students revealed that 80% were keenly interested in the topics and desired to have more such lectures. Half the students were able to answer all the five multiple-choice questions correctly.
Discussion Basic and comprehensive knowledge of psychiatry integrated with homoeopathic principles will allow students/physicians to know how cases are managed homeopathically from a more holistic and comprehensive point of view.
Conclusions Case-based presentations through the homoeopathic approach will enhance the confidence of the students in the ability of the science to take care of the psychologically distressed section of the population.
Homeopathic Treatment of Pododermatitis in Magellanic Penguins (Spheniscus magellanicus)
Authors: Narita Franscinne Brait , Scardoeli Bruna , Gallo Neto Hugo , Coelho Cidéli de Paula 
Published: December 2020

Abstract
Background Problems with the feet are common in penguins, with a particular predisposition to pododermatitis. This condition usually occurs due to the changes in normal activity that result from being held captive, but its precise pathogenesis is still undetermined.
Methods/Patients This veterinary case study reports the use of oral homeopathic treatment on acute and chronic pododermatitis in five Magellanic penguins in a zoological park setting. During treatment, the patients remained in the penguins' living area, and the effect of the treatment on the progression of their lesions was assessed visually once weekly. The treatment consisted of a combination of Arnica montana and Calcarea carbonica.
Results After treatment, the appearance of the lesions had noticeably improved: in the majority of penguins there was no longer evidence of infection or edema in the feet. The rate of recovery depended on the initial severity of the lesion. Those penguins that still showed signs of infection nevertheless exhibited a clear diminution of the size and thickness of the lesions. Homeopathic treatment did not cause any side effects.
Conclusion Homeopathy offers a useful treatment option for pododermatitis in captive penguins, with easy administration and without side effects.
Awareness on Preventive Measures taken by Health Care Professionals Attending COVID-19 Patients among Dental Students
Authors: Princeton Bianca , Santhakumar Preetha , Prathap Lavanya 
Published: December 2020

AbstractObjectives Coronavirus disease is an infectious disease caused by a newly discovered coronavirus. This virus primarily spreads through droplets of saliva or discharge from the nose when an infected person coughs or sneezes. This virus was named after its shape, which takes the form of a crown with protrusions around it. The World Health Organization has recommended personal protective equipments (PPE) to doctors and health care workers attending COVID-19 patients. PPE generally includes masks, goggles, respirators, gloves, face shields, and isolation gowns. The principle aim of this study is to create awareness among dental students about the preventive measures taken by health care professionals while attending patients affected with COVID-19.Materials & Methods A questionnaire comprising 15 questions was created using an online Google forms website and was circulated among 100 dental students. The survey was conducted within a week in the months of April to May 2020. The results and observations were recorded in the form of pie charts.Results Ninety-three percent of the participants have stated that health care professionals must clean their hands often, cover their nose and mouth, and maintain safe distance from everyone in order to prevent the virus from affecting them. Sixty-three percent of the participants are familiar with the term PPE. Majority assume that health care professionals are given enough safety precautions while treating a patient with coronavirus.Conclusion Hence, to conclude, health care professionals play a vital role in improving access and quality health care for the population, and hence, they must be protected as well. Since dental students treat patients, they are vulnerable to infection as well, and must take proper safety measures.
Evaluation of Pediatric Delirium Awareness and Management in Pediatric Intensive Care Units in Turkey
Authors: Konca Capan , Anil Ayse Berna , Küllüoglu Emine Pinar , Luleyap Doga , Anil Murat , Tekin Mehmet 
Published: December 2020

AbstractDelirium has been associated with prolonged pediatric intensive care unit (PICU) stay and mechanical ventilation times as well as high hospital costs and mortality rates. This work aimed to examine pediatric delirium awareness and delirium management in Turkey. A total of 19 physicians responsible for their respective PICUs completed the survey. Most of the units (57.9%) did not use any assessment tool. Varying measures were applied in different units to reduce the prevalence of delirium. The number of units that continuously measured noise was very low (15.8%). Eye mask and earpiece usage rates were also very low. In pharmacological treatment, haloperidol, dexmedetomidine, benzodiazepines, and atypical antipsychotics were the most preferred options. Some units have reached a sufficient level of pediatric delirium awareness and management. However, insufficiencies in delirium awareness and management remain in general.
Intrapartum Basal Ganglia–Thalamic Pattern Injury and Radiologically Termed “Acute Profound Hypoxic–Ischemic Brain Injury” Are Not Synonymous
Authors: Smith Johan , Solomons Regan , Vollmer Lindi , Langenegger Eduard J. , Lotz Jan W. , Andronikou Savvas , Anthony John , van Toorn Ronald 
Published: December 2020

Objective Human cases of acute profound hypoxic-ischemic (HI) injury (HII), in which the insult duration timed with precision had been identified, remains rare, and there is often uncertainty of the prior state of fetal health.
Study Design A retrospective analysis of 10 medicolegal cases of neonatal encephalopathy-cerebral palsy survivors who sustained intrapartum HI basal ganglia-thalamic (BGT) pattern injury in the absence of an obstetric sentinel event.
Results Cardiotocography (CTG) admission status was reassuring in six and suspicious in four of the cases. The median time from assessment by admission CTG or auscultation to birth was 687.5 minutes (interquartile range [IQR]: 373.5–817.5 minutes), while the median time interval between first pathological CTG and delivery of the infant was 179 minutes (IQR: 137–199.25 minutes). The mode of delivery in the majority of infants (60%) was by unassisted vaginal birth; four were delivered by delayed caesarean section. The median (IQR) interval between the decision to perform a caesarean section and delivery was 169 minutes (range: 124–192.5 minutes).
Conclusion The study shows that if a nonreassuring fetal status develops during labor and is prolonged, a BGT pattern HI injury may result, in the absence of a perinatal sentinel event. Intrapartum BGT pattern injury and radiologically termed “acute profound HI brain injury” are not necessarily synonymous. A visualized magnetic resonance imaging (MRI) pattern should preferably solely reflect the patterns description and severity, rather than a causative mechanism of injury.
Key Points
A Novel Simulation Model for Resident Education in Mechanical Cervical Ripening
Authors: Gimovsky Alexis C. , Pham Amelie , Gimovsky Martin , Wolf Abigail 
Published: December 2020

Introduction This study aims to evaluate resident satisfaction with a novel simulation model for learning transcervical balloon catheter placement for mechanical cervical ripening.Study Design A descriptive pretest and post-test survey study of Obstetrics and Gynecology (OBGYN) residents was conducted at a single academic medical center using a low-cost model.Results Of 28 residents, 14 (50%) were recruited. 100% of participants completed the pretest and post-test survey. Residents agreed that both learning and achieving correct placement of a transcervical balloon catheter are difficult. Pretest and post-test comparisons were statistically different with respect to comfort (2.8 ± 1.5 vs. 4.0 ± 1.0, p = 0.03) and ease of learning (3.1 ± 0.8 vs. 4.1 ± 0.6, p ≤ 0.001).Discussion We present a novel simulation model that can be used by OBGYN residents in training for learning transcervical balloon catheter placement for mechanical cervical ripening.Key Points
Pollution and health risk assessment of heavy metals in soils of Guizhou, China
Authors: Yu Gao , Chen Fen , Zhang Hongli , Wang Zuhua 
Published: December 2020

ABSTRACT
Mining of minerals in Guizhou, China, where it is enriched with reserves, may lead to soil contamination with heavy metals. We assessed the risk of eight typical heavy metals in Guizhou soils by collecting province-wide data available in the literature and using the geo-accumulation index method, the ecological risk assessment method, and the USEPA health risk assessment model. The concentrations of eight heavy metals, except for Pb and Cr, were above the background levels. Soil heavy metal pollution evaluation results showed that As, Cu, Zn, Pb, Cr, Cd, and Ni reached the pollution levels, while Hg fell into the category of moderate contamination. As, Cu, Zn, Pb, Cr, and Ni posed low potential ecological risk, while Cd and Hg demonstrated a considerable or a very high potential ecological risk. Totally, the integrated potential ecological risk was ranked “very high” . Regarding to health risk, the non-carcinogenic risks caused by heavy metals were insigniﬁcant, but the carcinogenic risk caused by As was signiﬁcant. Consequently, there appeared serious soil contamination of Hg and As, with the latter also being the greatest potential risk to human health. Both Hg and As should stay at the highest priory for remediation efforts in Guizhou soils.
Black hole collapse and bounce in effective loop quantum gravity
Authors: Kelly Jarod George , Santacruz Robert , Wilson-Ewing Edward 
Published: December 2020

Abstract
We derive effective equations with loop quantum gravity corrections for the Lemaître–Tolman–Bondi family of space-times, and use these to study quantum gravity effects in the Oppenheimer–Snyder collapse model. For this model, after the formation of a black hole with an apparent horizon, quantum gravity effects become important in the space-time region where the energy density and space-time curvature scalars become comparable to the Planck scale. These quantum gravity effects first stop the collapse of the dust matter field when its energy density reaches the Planck scale, and then cause the dust field to begin slowly expanding. Due to this continued expansion, the matter field will eventually extend beyond the apparent horizon, at which point the horizon disappears and there is no longer a black hole. There are no singularities anywhere in this space-time. In addition, in the limit that edge effects are neglected, we show that the dynamics for the interior of the star of uniform energy density follow the loop quantum cosmology effective Friedman equation for the spatially flat Friedman–Lemaître–Robertson–Walker space-time. Finally, we estimate the lifetime of the black hole, as measured by a distant observer, to be ∼(GM)2/ℓ
Pl.