bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applicability of augmented reality in orthopedic surgery – A systematic review
Authors: Jud Lukas , Fotouhi Javad , Andronic Octavian , Aichmair Alexander , Osgood Greg , Navab Nassir , Farshad Mazda 
Published: February 2020

Abstract
Background
Computer-assisted solutions are changing surgical practice continuously. One of the most disruptive technologies among the computer-integrated surgical techniques is Augmented Reality (AR). While Augmented Reality is increasingly used in several medical specialties, its potential benefit in orthopedic surgery is not yet clear. The purpose of this article is to provide a systematic review of the current state of knowledge and the applicability of AR in orthopedic surgery.

Methods
A systematic review of the current literature was performed to find the state of knowledge and applicability of AR in Orthopedic surgery. A systematic search of the following three databases was performed: “PubMed”, “Cochrane Library” and “Web of Science”. The systematic review followed the Preferred Reporting Items on Systematic Reviews and Meta-analysis (PRISMA) guidelines and it has been published and registered in the international prospective register of systematic reviews (PROSPERO).

Results
31 studies and reports are included and classified into the following categories: Instrument / Implant Placement, Osteotomies, Tumor Surgery, Trauma, and Surgical Training and Education. Quality assessment could be performed in 18 studies. Among the clinical studies, there were six case series with an average score of 90% and one case report, which scored 81% according to the Joanna Briggs Institute Critical Appraisal Checklist (JBI CAC). The 11 cadaveric studies scored 81% according to the QUACS scale (Quality Appraisal for Cadaveric Studies).

Conclusion
This manuscript provides 1) a summary of the current state of knowledge and research of Augmented Reality in orthopedic surgery presented in the literature, and 2) a discussion by the authors presenting the key remarks required for seamless integration of Augmented Reality in the future surgical practice.

Trial registration
PROSPERO registration number: CRD42019128569.
Biomechanical changes of degenerated adjacent segment and intact lumbar spine after lumbosacral topping-off surgery: a three-dimensional finite element analysis
Authors: Cao Liangliang , Liu Yumei , Mei Wei , Xu Jianguang , Zhan Shi 
Published: February 2020

Abstract
Background
Previous studies have revealed positive effect of Topping-off technique on upper adjacent segment after fusion surgery, while for the cases with fusion surgery on L5-S1 segment, owning maximal range of motion, and preexisting degenerated upper adjacent disc, it is necessary to clarify the superiority of Topping-ff technique and the effect exerted on the lumbar spine.

Methods
A young healthy male volunteer was selected for thin-slice CT scanning. Then the image information was imported into the computer to establish the whole lumbar spine model as the health model. The medium degeneration model of intervertebral disc was established by changing the material properties of L4-S1 disc on the basis of the health model, and the fusion model and Topping-off model were respectively established on the basis of the degenerated model. The variation trend of ROM of L2-L5 and the stress changes of L4-L5 intervertebral disc, nucleus pulposus and facet joints were calculated respectively.

Results
The L4-L5 ROM of fusion model increased significantly but the ROM of L2-L3 and L3-L4 segments did not change significantly. Compared with the degenerated model, L4-L5 activity of the Topping-off model decreased, and ROM of the L2-L3 and L3-L4 increased to some extent in the flexion and extension positions. The stress on the disc, nucleus pulposus and facet joint of the fusion model L4-L5 increased in four positions of flexion, extension, rotation and bending compared with the degenerated model, while the fiber stress on the Topping-off model decreased significantly in all four positions.

Conclusion
Topping-off technology can decrease the stress and ROM of the adjacent upper degenerated segment, and increase the ROM of other upper segments, thereby protecting the degenerated upper adjacent segments and compensating the lumbar spine mobility.
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract
Authors: Han Li , Cao Xueyun , Chen Zhong , Guo Xiaojuan , Yang Lei , Zhou Yubing , Bian Hua 
Published: February 2020

Abstract
Background
The well-known traditional Chinese herbal formula Guizhi Fuling Wan (GFW) was recently reported to improve the curative effects of chemotherapy for ovarian cancer with few clinical side effects. The present study aimed to investigate the reversal mechanism of sera derived from rats exposed to Guizhi Fuling Wan extract (GFWE) in cisplatin-resistant human ovarian cancer SKOV3/DDP cells; the proteins examined included phosphatase and tensin homolog (PTEN) and metadherin (MTDH), and the possible protein interaction between PTEN and MTDH was explored.

Methods
GFWE was administered to healthy Wistar rats, and the sera were collected after five days. The PubMed and CNKI databases were searched for literature on the bioactive blood components in the sera. The systemsDock website was used to predict potential PTEN/MTDH interactions with the compounds. RT-qPCR, western blotting, and immunofluorescence analyses were used to analyze the mRNA and protein levels of MTDH and PTEN. Laser confocal microscopy and coimmunoprecipitation (co-IP) were used to analyze the colocalization and interaction between MTDH and PTEN.

Results
Sixteen bioactive compounds were identified in GFWE sera after searching the PubMed and CNKI databases. The systemsDock website predicted the potential PTEN/MTDH interactions with the compounds. RT-qPCR, western blotting, and immunofluorescence analyses showed decreased MTDH expression and increased PTEN expression in the sera. Laser confocal microscopy images and coimmunoprecipitation (co-IP) analyses demonstrated that a colocalization and interaction occurred between MTDH and PTEN, and the addition of the sera changed the interaction status.

Conclusions
GFWE restored sensitivity to cisplatin by inhibiting MTDH expression, inducing PTEN expression, and improving the interaction between MTDH and PTEN in SKOV3/DDP cells, and these proteins and their interaction may serve as potential targets for cancer treatment. The sera may represent a new source of anticancer compounds that could help to manage chemoresistance more efficiently and safely.
Corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
Authors: Sirkka Jani , Säisänen Laura , Julkunen Petro , Könönen Mervi , Kallioniemi Elisa , Leinonen Ville , Danner Nils 
Published: February 2020

Abstract
Background
Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease with an unknown etiology. Disturbed corticospinal inhibition of the motor cortex has been reported in iNPH and can be evaluated in a noninvasive and painless manner using navigated transcranial magnetic stimulation (nTMS). This is the first study to characterize the immediate impact of cerebrospinal fluid (CSF) drainage on corticospinal excitability.

Methods
Twenty patients with possible or probable iNPH (16 women and 4 men, mean age 74.4 years, range 67–84 years), presenting the classical symptom triad and radiological findings, were evaluated with motor function tests (10-m walk test, Grooved Pegboard and Box & Block test) and nTMS (silent period, SP, resting motor threshold, RMT and input–output curve, IO-curve). Evaluations were performed at baseline and repeated immediately after CSF drainage via lumbar puncture.

Results
At baseline, iNPH patients presented shorter SPs (p < 0.001) and lower RMTs (p < 0.001) as compared to normative values. Positive correlation was detected between SP duration and Box & Block test (rho = 0.64, p = 0.002) in iNPH patients. CSF drainage led to an enhancement in gait velocity (p = 0.002) and a steeper IO-curve slope (p = 0.049).

Conclusions
Shorter SPs and lower RMTs in iNPH suggest impaired corticospinal inhibition and corticospinal hyperexcitability. The steeper IO-slope in patients who improve their gait velocity after CSF drainage may indicate a higher recovery potential. Corticospinal excitability correlated with the motor function of the upper limbs implying that the disturbance in motor performance in iNPH extends beyond the classically reported gait impairment.
Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies
Authors: Dhiman Priyanka , Malik Neelam , Khatkar Anurag 
Published: February 2020

AbstractNeurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species. The computational design of the piperine derivatives has given the significant MAO inhibitors with considerable antioxidant potential. Molecular docking provided the mechanistic insight of the compounds within the hMAO active site. In the current study we have prepared a series of compounds related to piperine and investigated them through monoamine oxidase A and B assay and evaluated the free radical scavenging activity. The synthesized compounds were analyzed by using in silico techniques within the active site of MAO and the ADMET properties were also calculated. The results obtained in this study indicated the interesting therapeutic potential of some compounds such as 7and 17c as most promising hMAO-A inhibitors whereas compounds 15, 5 and 17b were found as hMAO-B inhibitors. Moreover, we assessed the antioxidant potential of the piperine analogues and compounds 5, 17b, and 7 showed very modest antioxidant activity against DPPH and H2O2 radicals. The outcome of the study indicating that the piperine related derivatives are found as considerable MAO inhibitors and antioxidants. Moreover, the SAR structure activity relationships are depicting the structural features required for the MAO inhibition. In case of MAO activity, good correlations were found among the calculated and experimental results.
Ingested insecticide to control Aedes aegypti: developing a novel dried attractive toxic sugar bait device for intra-domiciliary control
Authors: Sippy Rachel , Rivera Galo E. , Sanchez Valeria , Heras Froilán , Morejón Bianca , Beltrán Efraín , Hikida Robert S. , López-Latorre María A. , Aguirre Alex , Stewart-Ibarra Anna M. , Larsen David A. , Neira Marco 
Published: February 2020

Abstract
Background
Illnesses transmitted by Aedes aegypti (Linnaeus, 1762) such as dengue, chikungunya and Zika comprise a considerable global burden; mosquito control is the primary public health tool to reduce disease transmission. Current interventions are inadequate and insecticide resistance threatens the effectiveness of these options. Dried attractive bait stations (DABS) are a novel mechanism to deliver insecticide to Ae. aegypti. The DABS are a high-contrast 28 inch2 surface coated with dried sugar-boric acid solution. Aedes aegypti are attracted to DABS by visual cues only, and the dried sugar solution elicits an ingestion response from Ae. aegypti landing on the surface. The study presents the development of the DABS and tests of their impact on Ae. aegypti mortality in the laboratory and a series of semi-field trials.

Methods
We conducted multiple series of laboratory and semi-field trials to assess the survivability of Ae. aegypti mosquitoes exposed to the DABS. In the laboratory experiments, we assessed the lethality, the killing mechanism, and the shelf life of the device through controlled experiments. In the semi-field trials, we released laboratory-reared female Ae. aegypti into experimental houses typical of peri-urban tropical communities in South America in three trial series with six replicates each. Laboratory experiments were conducted in Quito, Ecuador, and semi-field experiments were conducted in Machala, Ecuador, an area with abundant wild populations of Ae. aegypti and endemic arboviral transmission.

Results
In the laboratory, complete lethality was observed after 48 hours regardless of physiological status of the mosquito. The killing mechanism was determined to be through ingestion, as the boric acid disrupted the gut of the mosquito. In experimental houses, total mosquito mortality was greater in the treatment house for all series of experiments (P < 0.0001).

Conclusions
The DABS devices were effective at killing female Ae. aegypti under a variety of laboratory and semi-field conditions. DABS are a promising intervention for interdomiciliary control of Ae. aegypti and arboviral disease prevention.
Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb
Authors: Laitila Jenni M. , McNamara Elyshia L. , Wingate Catherine D. , Goullee Hayley , Ross Jacob A. , Taylor Rhonda L. , van der Pijl Robbert , Griffiths Lisa M. , Harries Rachel , Ravenscroft Gianina , Clayton Joshua S. , Sewry Caroline , Lawlor Michael W. , Ottenheijm Coen A. C. , Bakker Anthony J. , Ochala Julien , Laing Nigel G. , Wallgren-Pettersson Carina , Pelin Katarina , Nowak Kristen J. 
Published: February 2020

AbstractNemaline myopathy (NM) caused by mutations in the gene encoding nebulin (NEB) accounts for at least 50% of all NM cases worldwide, representing a significant disease burden. Most NEB-NM patients have autosomal recessive disease due to a compound heterozygous genotype. Of the few murine models developed for NEB-NM, most are Neb knockout models rather than harbouring Neb mutations. Additionally, some models have a very severe phenotype that limits their application for evaluating disease progression and potential therapies. No existing murine models possess compound heterozygous Neb mutations that reflect the genotype and resulting phenotype present in most patients. We aimed to develop a murine model that more closely matched the underlying genetics of NEB-NM, which could assist elucidation of the pathogenetic mechanisms underlying the disease. Here, we have characterised a mouse strain with compound heterozygous Neb mutations; one missense (p.Tyr2303His), affecting a conserved actin-binding site and one nonsense mutation (p.Tyr935*), introducing a premature stop codon early in the protein. Our studies reveal that this compound heterozygous model, NebY2303H, Y935X, has striking skeletal muscle pathology including nemaline bodies. In vitro whole muscle and single myofibre physiology studies also demonstrate functional perturbations. However, no reduction in lifespan was noted. Therefore, NebY2303H,Y935X mice recapitulate human NEB-NM and are a much needed addition to the NEB-NM mouse model collection. The moderate phenotype also makes this an appropriate model for studying NEB-NM pathogenesis, and could potentially be suitable for testing therapeutic applications.
Geochemical and petrographic identification of stone quarries used for the construction of the Anahita Temple of Kangavar (West Iran)
Authors: Shekofteh Atefeh , Oudbashi Omid , Cultrone Giuseppe , Ansari Masoud 
Published: February 2020

Abstract
The archaeological site of the Anahita Temple in Kangavar is one of the best-known stone monuments in western Iran and dates back to the Persian Empire period of Iranian history (about 550 BC to 650 AD). The Temple was constructed on a semi-artificial hill out of large stone blocks, many of which are cubic in shape, and short thick columns. In the Kangavar area (basin) there are various sites in which there is evidence of stone extraction. The aim of this paper is to characterize the stones used in the Anahita Temple of Kangavar and their correlations with the quarrying activities observed in the Kangavar regions. In fact, we tried to find out which of these quarries may have been the source of the stone blocks used in the construction of the Anahita Temple. To this end the stones used in the Temple have been characterized by conducting a multi-analytical study involving chemical, mineralogical and textural analyses including XRF, XRD and thin section petrography. The results show that although all the quarries could have provided the stone used in the construction of the Temple, the largest, most probable source was the Chel Maran quarry. It is due to the more similarity of stones used in the Anahita Temple and the samples from this quarry from geochemical point of view as well as the archaeological evidences present in this quarry. The results are also useful for conservators to select appropriate materials for reconstruction of the decayed parts of the Anahita Temple.
Clinical, microbiological, and immunological evaluation of patients in corrective orthodontic treatment
Authors: Shirozaki Mariana Umekita , da Silva Raquel Assed Bezerra , Romano Fábio Lourenço , da Silva Léa Assed Bezerra , De Rossi Andiara , Lucisano Marília Pacífico , Messora Michel Reis , Feres Magda , Novaes Júnior Arthur Belém 
Published: February 2020

Abstract
Background
The objective was to analyze clinical, microbiological, and immunological periodontal parameters in patients in corrective orthodontic treatment.

Materials and methods
Twenty-eight patients were selected. Plaque index (PI), bleeding on probing (BOP), width of keratinized gingiva, levels of 40 bacterial species, and of 3 cytokines (IL-1β, MMP-8, and TNF-α) in gingival crevicular fluid (GCF) were evaluated at T0, before orthodontic treatment; T1, 6 months; and T2, 12 months post-treatment. Non-parametric, Friedman, Wilcoxon, ANOVA, and Spearman correlation coefficient tests were used for statistical analyses, with the significance level of 5%.

Results
No significant difference was found for the width of keratinized gingiva, but PI presented a significant increase at T1 and T2 (p < 0.05) when compared with T0. The percentage of sites with BOP increased significantly from T0 to T1 (p < 0.05); however, at T2, the values decreased and did not differ anymore from T0 (p > 0.05). In the microbiological analysis, red complex pathogens were in significantly greater proportions in T2 compared with T0 (p < 0.05). There was no statistically significant difference in the cytokine levels between the periods but there was a positive correlation between BOP and IL-1β (r = 0.49 p = .01) and TNF-α (r = 0.39 and p = .05).

Conclusion
In conclusion, corrective orthodontic treatment caused clinical periodontal alterations regarding biofilm accumulation and gingival bleeding, with alteration of periodontopathogens.
Friction and noise suppression for force control system based on integration of observer and force sensor information
Authors: Nagatsu Yuki , Hashimoto Hideki 
Published: February 2020

AbstractMeasuring and controlling external force from the environment and human beings are essential to realize the future application of the robot systems for medical, nursing, and personal support systems. This paper proposes a friction and noise suppression for force control system based on the integration of the reaction torque observer and force (torque) sensor information. The proposed method performs external force estimation by integrating the low-frequency component information of the force sensor and the high-frequency component of the force information estimated by reaction torque observer (RTOB). By using the low-frequency component of the force sensor, the effect of static friction can be suppressed, and the high-frequency part of RTOB can be used to attenuate the noise component. As a result, the performance of the force control system can be enhanced. The proposed method is evaluated through the experiments of the force control and bilateral control as a position/force hybrid control.
Ambiguous goals, uneven implementation – how immigration offices shape internal immigration control in Germany
Authors: Schultz Caroline 
Published: February 2020

AbstractThis paper investigates regional variation in migration policy implementation, focusing specifically on the underexplored role of policy ambiguity. It chooses a salient case study of internal migration control implementation: the application of labour market access policies for migrants with precarious legal status in German municipal immigration offices. Studying the implementation approaches of eleven offices within one Land by means of semi-structured interviews with senior officials, the research design allows for drawing inter-agency and inter-policy comparisons. The data provides empirical evidence for the claim that the more conflictive and hence ambiguous a policy, the more importance can be placed on local determinants of implementation. Different logics (economic welfare and regulatory control logic) legitimizing more restrictive or expansive implementation are identified and linked to the broader migration policy context. Moreover, the difficult task of officials to determine applicants’ identity clarification efforts – a condition for receiving a work permit – serves as basis for conceptually distinguishing between collective and individual discretion of street-level bureaucrats.
Severe and persistent nerve palsy after ultrasound-guided continuous interscalene brachial plexus block in a teenager undergoing shoulder surgery: a case report
Authors: Shio Hisashi , Sakura Shinichi , Motooka Akihiro , Sakai Yasuo , Saito Yoji 
Published: February 2020

AbstractBackgroundAlthough neurologic sequela is a recognized complication after interscalene brachial plexus block (ISB), there is a paucity of information on how severe and persistent neuropathy occurs and develops.Case presentationA healthy high school soccer goalkeeper was scheduled for an arthroscopic Bankart repair. After continuous ISB for 2 days, sensation in the C5 and C6 areas and motor function did not return. With symptomatic drug treatment for neuropathic pain and rigorous rehabilitation, recovery of sensory loss and muscle weakness were gradually observed around 1 to 2 months after surgery. He returned to sport 1 year after surgery.ConclusionThis report is the first detailed description of a case who incurred severe and persistent nerve injury after continuous ISB yet recovered nearly fully to return to being an athlete. The present case should also underscore the importance of close observation after surgery in cases where a patient receives continuous ISB.
Pilot protection of hybrid MMC DC grid based on active detection
Authors: Song Guobing , Hou Junjie , Guo Bing , Chen Zhehong 
Published: February 2020

AbstractConsidering the advantages and limitations of traditional identification method, combined with the strategy of active detection, the principle of DC grid pilot protection based on active detection is proposed to improve the sensitivity and reliability of hybrid MMC DC grid protection, and to ensure the accurate identification of fault areas in DC grid. By using the DC fault ride-through control strategy of the hybrid sub-module MMC, the fault current at the converter station DC terminal is limited. Based on the high controllability of hybrid MMC, sinusoidal fault detection signals with the same frequency are injected into the line at each converter station. Based on model recognition, the capacitance model condition is satisfied by the detected signals at both ends during external faults whereas not satisfied during internal faults. The Spearman correlation coefficients is then introduced, and the correlation discriminant of capacitance model is constructed to realize fault area discrimination of DC grid. The simulation results show that the active detection protection scheme proposed in this paper can accurately identify the fault area of DC grid, and is not affected by fault impedance and has low sampling rate requirement.