bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brachial-Ankle Pulse Wave Velocity is Associated With the Risk of Osteoporosis: A Cross-Sectional Evidence From A Chinese Community-Based Cohort
Authors: Tang Kun , Zhang Qiao , Peng Nianchun , Hu Ying , Xu Shujing , Zhang Miao , Wang Rui , Shi Lixin 
Published: September 2020

Abstract
Background: Association of arterial stiffness and osteoporosis has been investigated in Chinese population. However, the relationship between arterial stiffness and osteoporosis by measuring brachial-ankle pulse wave velocity (baPWV) and the Osteoporosis Self‐assessment Tool for Asia (OSTA) index is not established. The object of this study was to evaluate possible associations between baPWV and the risk of osteoporosis and bone fracture among a population of Chinese. Whether baPWV can be used as a predictor of osteoporosis on OSTA was further assessed. Methods: This study was cross-sectional in design. Of 3,984 adults aged 40 years and older in the Yunyan district of Guiyang (Guizhou, China) who underwent both OSTA and baPWV measurements within one month , 1,407 were deemed eligible for inclusion (women: 1,088, men: 319) . Results: The mean baPWV was 1,475 ± 302 cm/s (range,766-3,459cm/s). baPWV in 110 individuals with high risk of osteoporosis (OSTA index < -4) was higher than that of individuals with non-high risk (1,733 ± 461 cm/s versus 1,447 ± 304 cm/s, P<0.001). OSTA index was negatively correlated with baPWV（ρ = -0.296，P < 0.001）after adjusting for age, sex, body mass index, waist circumference, diastolic blood pressure and creatinine clearance rate. baPWV was an independent predictor for the presence of high risk of osteoporosis (β = -0.001, P < 0.001) and the optimal baPWV cut-off value for predicting the presence of high risk of osteoporosis and fracture was 1,693 cm/s. The AUC was 0.722 (95% confidence interval [CI], 0.667‐0.777; P < 0.001). Conclusions: We conclude that arterial stiffness measured by baPWV is well correlated with the severity of osteoporosis evaluated by OSTA. baPWV index may be a valuable tool for identifying individuals with risk of developing osteoporosis.
Identification of Differentially Expressed Genes and Signaling Pathways Related to Ovarian Endometriosis by Integrated Bioinformatics Analysis
Authors: Lin Kainan , Pan Zhenyan , He Renke , Wang Hanchu , Zhou Kai , Mu Liangshan 
Published: September 2020

Abstract
Purpose: Endometriosis was a common gynecological disease, however, the specific mechanism and the key molecules of endometriosis remained uncertain. This study aimed to single out key genes associated with poor prognosis, and further uncover underlying mechanisms.Methods: Data regarding mRNA expression profiles used in this study were retrieved from the Gene Expression Omnibus (GEO) database, a total of three mRNA expression profiles were included for subsequent analysis (GSE31515, GSE58178 and GSE120103). Then, we conducted Gene Ontology analysis (GO analysis), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and protein-protein interaction (PPI) analysis by the software R.Results: A total of 304 differentially expressed genes (DEGs) between endometriosis tissues and normal endometrium tissues were identified in integrated analysis, including 185 up-regulated genes and 119 down-regulated genes. GO analysis reveals that the DEGs of endometriosis were closely associated with molecular origin of bacteria. KEGG pathway enrichment analysis indicates that the DEGs were mainly involved in AGE-RAGE signaling pathway in diabetic complications. In addition, PPI of these DEGs was visualized by Cytoscape platform with utilization of Search Tool for the Retrieval of Interacting Genes (STRING). PPI analysis identifies 10 potential DEGs-related protein targets, including CCND1, IL6, CCL2, COL1A2, PTGS2, VCAM1, COL3A1, ELN, SERPINE1, HSP90B1. Conclusion: In conclusion, the present study reveals that bacterial contamination, defect of female reproductive system development, retrograde menstruation and the AGE-RAGE signaling pathway may be involved in the development of endometriosis In addition, these identified DEGs may be of clinical significance for the diagnosis and treatment of the endometriosis.
The Reliability and Validity of the Japanese Version of the Daily Record of Severity of Problems (J-DRSP) and Development of a Short-Form Version (J-DRSP(SF)) to Assess Symptoms of Premenstrual Syndrome Among Japanese Women
Authors: Ikeda Yumie , Egawa Miho , Okamoto Kazuya , Mandai Masaki , Takahashi Yoshimitsu , Nakayama Takeo 
Published: September 2020

Abstract
Purpose
To assess the validity and reliability of the Japanese version of the Daily Record of Severity of Problems (J-DRSP, 24 items) for evaluating symptoms of premenstrual syndrome (PMS), and to develop a short form version of the J-DRSP.
Methods
Using the “DRSP-JAPAN” smartphone app, we collected daily J-DRSP records from 7 days before to 10 days after each participant’s menstruation onset date. Factorial validity (exploratory factor analysis: EFA, confirmatory factor analysis: CFA) and criterion validity were examined. We evaluated test-retest reliability (intraclass correlation: ICC) and obtained Cronbach's alpha coefficients. The short-form version of the J-DRSP was developed using classical test theory.
Results
In total, 304 women participated and 243 recorded symptoms on at least 4 days spanning the week of the luteal phase (CD-6 to CD0) and 4 days spanning the week of the follicular phase (CD4 to CD10), with CD1 representing the menstruation onset date. With CD0 set as one day before menstruation onset date, the EFA revealed a two-factor structure. KMO was 0.992, and Bartlett's test of sphericity chi-square was 3653.89 (P < 0.001). However, the model fitness of CFA was found to be suboptimal (CFI: 0.83, RMSEA: 0.12). Total scores for J-DRSP and the sum scores for each subscale were higher on CD10 than on CD0 (p < 0.001), suggesting validity for some criteria. ICC values for the total J-DRSP score from CD0 to CD-1, and between CD9 to CD-10, were 0.60 (95% CI: 0.48–0.72) and 0.76 (95% CI: 0.69–0.82), respectively. For participants reporting significant interference in their daily life one day out of CD-1 and CD0 or CD9 and CD10, ICCs were 0.79 (0.68–0.86) among 76 participants and 0.88 (0.76–0.84) among 30 participants. Having eliminated some original items after considering factor loading for each item, we developed an 8-item Short-Form J-DRSP (J-DRSP(SF)) comprising 2 factors (S-Psychological and S-Physical, 4 items for each). CFA showed a better model fit (CFI: 0.99, RMSEA: 0.048) with significantly higher scores for the J-DRSP(SF), S-Psychological, and S-Physical in the luteal phase than in the follicular phase (p < 0.001). Cronbach's alphas for the J-DRSP(SF), S-Psychological, and S-Physical were 0.89, 0.89, and 0.80, respectively. ICC values for the J-DRSP(SF) in the luteal and follicular phases were 0.61 (95%CI: 0.51–0.68) and 0.70 (95%CI: 0.62–0.77), respectively.
Conclusion
The J-DRSP has moderate to good reliability and certain level of validity. The J-DRSP(SF) has a two-factor structure and can be used effectively among Japanese women to assess their PMS symptoms.
SAT-Attack Resistant Hardware Obfuscation using Camouflaged Two-Dimensional Heterostructure Devices
Authors: Wali Akshay , Arnold Andrew , Kundu Shamik , Choudhury Soumyadeep , Basu Kanad , Das Saptarshi 
Published: September 2020

Abstract
Reverse engineering (RE) is one of the major security threats to the semiconductor industry due to the involvement of untrustworthy parties in an increasingly globalized chip manufacturing supply chain [1-5]. RE efforts have already been successful in extracting device level functionalities from an integrated circuit (IC) with very limited resources [6]. Camouflaging is an obfuscation method that can thwart such RE [7-9]. Existing work on IC camouflaging primarily uses fabrication techniques such as doping and dummy contacts to hide the circuit structure or build cells that look alike but have different functionalities. While promising these Si complementary metal oxide semiconductor (CMOS) based obfuscation techniques adds significant area overhead and are successfully decamouflaged by the Satisfiability solver (SAT)-based reverse engineering techniques [9-13]. Emerging solutions, such as polymorphic gates based on giant spin Hall effect (GSHE) are promising but adds delay overhead in hybrid CMOS-GSHE designs restricting the camouflaging to a maximum of 15% of all the gates in the circuit. Here, we harness the unique properties of two-dimensional (2D) transition metal dichalcogenides (TMDs) including MoS2, MoSe2, MoTe2, WS2, and WSe2 and their optically transparent transition metal oxides (TMOs) to demonstrate novel area efficient camouflaging solutions that are resilient to SAT-attack and automatic test pattern generation (ATPG) attacks. We show that resistors with resistance values differing by 8 orders of magnitude, diodes with variable turn-on voltages and reverse saturation currents, and field effect transistors (FETs) with adjustable conduction type, threshold voltages and switching characteristics can be optically camouflaged to look exactly similar by engineering TMO/TMD heterostructures allowing hardware obfuscation of both digital and analog circuits. Since this 2D heterostructure devices family is intrinsically camouflaged, NAND/NOR/AND/OR gates in the circuit can be obfuscated with significantly less area overhead allowing 100% logic obfuscation compared to only 5% for CMOS-based camouflaging. Finally, we demonstrate that the largest benchmarking circuit from ISCAS’85, comprised of more than 4000 logic gates when obfuscated with the CMOS-based technique are successfully decamouflaged by SAT-attack in less than 40 minutes; whereas, it renders to be invulnerable even in more than 10 hours, when camouflaged with 2D heterostructure devices thereby corroborating our hypothesis of high resilience against RE. Our approach of connecting unique material properties to innovative devices to secure circuits can be considered as one of its kind demonstrations, highlighting the benefits of cross-layer optimization.
A randomized controlled trial comparing peginterferon-α-2a versus observation after stopping tyrosine kinase inhibitor in chronic myeloid leukemia patients with deep molecular response for at least two years
Authors: Kuan Jew Win , Chang Kian Meng , Phan Chin Lee , Wong Shu Ping , Lim Soo Min , Toh See Guan , Loh Weng Khean , Begum Habiba Nazeera , Hon Siong Heng , Ng Si Yuan , Chiang Su Kien , Chai Alvin Jung Mau , Yong Kar Ying , Teo Hock Gin , Tang Andy Sing Ong , Wilfred Gilbert , Guan Yong Khee , Wong Lily Lee Lee , Ko Ching Tiong 
Published: September 2020

Abstract
BackgroundInterferon (IFN) is a logical possibility to increase treatment free remission (TFR) rate in chronic myeloid leukemia (CML). We conducted the first randomized controlled trial comparing the use of pegIFN versus observation in CML patients attempting TFR.MethodsAdult CML patients with stable deep molecular response for ≥ 2 years with ≥ 2 readings of MR4.5 were randomized into two arms -- subcutaneous pegIFN-α-2a starting at 180 µg weekly for a year, followed by observation, or observation.ResultsA total of 30 patients were recruited (pegIFN n = 15, observation n = 15). Median follow-up was 38.1 months (range 15.9–49.4) and 23.8 (1.5–51.0) in pegIFN and observation arm, respectively. A total of 11 patients relapsed (pegIFN n = 4, observation n = 7). The median time of relapse was 13.1 months (range 9.2 to 25.5) and 4.4 (1.2 to 13.6) in pegIFN and observation arm, respectively. Only 8 out of 15 (53%) patients completed 52 doses of pegIFN with mean dose of 43 out of 52 doses (range 20 to 52). Dose of tolerable pegIFN was age dependent.ConclusionPegIFN is a potential consolidative therapy to increase TFR.Trial registration:(1) Malaysia National Medical Research Register (NMRR): NMRR-13-1186-15491. Approved 23rd September 2014, https://www.nmrr.gov.my/fwbLoginPage.jsp(2) ClinicalTrials.gov: NCT02381379. Registered on 24th Feb 2015, https://clinicaltrials.gov/ct2/results?cond=&term=NCT02381379&cntry=&state=&city=&dist=
A Mid- to Long-Term Results of The Avascular Fibular Grafting in ONFH With 6 to 8-Year Follow-Up
Authors: Yuan Peng , Du Bin , Liu Xin , Sun Guang-Quan , Lin Xuan-Ye , Wang Xu 
Published: September 2020

Abstract
Background: Free vascularized fibular grafting was reported a favorable method to prevent the collapse of the femoral head. Nevertheless, this operation is traumatic and expensive. This study analyzed the long-term outcomes of avascular fibular grafting for osteonecrosis of the femoral head(ONFH) with 6 to 8 year follow-up.Methods: From March 2009 to March 2012, 34 patients(48 hips) were diagnosed the ONFH with Association Research Circulation Osseous(ARCO) stage of Ⅱ to Ⅲb and operated with avascular fibular grafting in Jiangsu Province Hospital of traditional Chinese Medicine. We retrospectively reviewed the clinic effects of these patients and assessed the difference effects with diverse stages(ARCO) and types(China-Japan Friendship Hospital classification, CJFH) annually. The hip survival rate, Harris hip score, activity level and imaging stability were calculated. The average follow-up time was 6.7 years.Results: At the last follow-up,34 of 48 hips survived totally. Depending on the ARCO stage, The overall clinical success rate for hip preserving were 76.0% (19/25) in Ⅱ stage ,85.7%(12/14) in ⅢA stage and 33.3%(3/9) in ⅢB stage. Referring to the CJFH classification system, the hip survival rate were 100%(2/2) in M type,90.9%(10/11) in C type,77.8%(14/18) in L1 type,57.1%(8/14) in L2 type and 0%(0/3) in L3 type. The mean VAS score, HHS, and WOMAC were significantly improved at the final follow-up compared with preoperative values (p < 0.001).Conclusion: The avascular fibular grafting operation can increase the hip function and improve patients’ lives quality. It possesses vast clinical as well as practical significance, because the long-term efficacy can satisfy fundamental life requirements, especially for those early-stage and small-scale patients who suffer ONFH to avoid or put off the time of total hip arthroplasty(THA) surgery.
Chromosome-scale assembly and analysis of biomass crop Miscanthus lutarioriparius genome
Authors: Miao Jiashun , Feng Qi , Li Yan , Zhao Qiang , Zhou Congcong , Lu Hengyun , Fan Danlin , Lu Yiqi , Tian Qilin , Li Wenjun , Weng Qijun , Zhang Lei , Zhao Yan , Huang Tao , Yan Juan , Li Laigeng , Huang Xuehui , Sang Tao , Han Bin 
Published: September 2020

Abstract
The genus Miscanthus, a rhizomatous perennial plant, has great potential for bio-energy production for its high biomass yield and strong stress resistance. Here, we generated the first chromosome-scale assembly of Miscanthus lutarioriparius Nandi by combining Oxford Nanopore sequencing and Hi-C technologies. The 2.07-Gb assembly covers 96.64% of the genome, with contig N50 of 1.71 Mb. By utilizing Hi-C data, 1,956.46 Mb (94.30%) of the assembled sequences were anchored and oriented to 19 pseudochromosomes of haploid M. lutarioriparius. The diploid M. lutarioriparius was identified to have a typical tetraploid genome structure. With the chromosome-level genome assembly, a series of structural variation, including chromosomal fragmentation, fusion and rearrangement relative to sorghum genome were clearly characterized. The tandem duplicate genes of M. lutarioriparius were enriched not only in the GO terms related to biotic and abiotic stress response, but also in the cell wall biosynthesis. Comparative genome analysis revealed that the gene families related to disease resistance, cell wall biosynthesis and metal ion transport were greatly expanded and evolved. The gene families associated with the distinctive features of M. lutarioriparius were analyzed in detail, involving cell wall biosynthesis, disease resistance and C4 photosynthesis pathways. Besides the recent whole genome duplication, tandem duplication has played critical role in the expansion of size of these gene families investigated. While the transcriptome data showed that most duplicated gene members had extremely low level of expression in all transcriptome samples or the expected sample. The expansion of these families probably be an important genomic basis for the enhancement of those remarkable traits of M. lutarioriparius. These candidate gene members also provide valuable gene resource for function analysis and genetic improvement for M. lutarioriparius.
WITHDRAWN: Dysregulation of miR-129-5p in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance
Authors: Zhang Han , Niu Qinghui , Liang Kun , Li Xuesen , Jiang Jing , Bian Cheng 
Published: September 2020

Abstract
Background: Non-alcoholic fatty liver (NAFLD) is the hepatic manifestation of metabolic syndromes, insulin resistance (IR) is related to the occurrence of NAFLD. The purpose of this study was to evaluate the expression of miR-129-5p in NAFLD patients and its clinical value, and explore its regulatory effect on IR.Methods: 117 NAFLD patients and 110 healthy controls were included. The levels of miR-129-5p were detected by qRT-PCR. To assess the diagnostic value of miR-129-5p for NAFLD, the receiver operating characteristic curve (ROC) was established. C57Bl/6 mice were supplied with high-fat diet to establish NAFLD model. Intraperitoneal insulin tolerance test (IPITT) was carried out to evaluate the effect of miR-129-5p on IR in NAFLD animal model.Results: miR-129-5p was highly expressed in the serum of NAFLD patients, and patients with HOMA-IR ≥ 2.5 had higher level of miR-129-5p than those with HOMA-IR < 2.5. miR-129-5p had the ability to differentiate NAFLD patients from healthy individuals, and might be associated with the development of IR. Serum miR-129-5p was positively correlated with the levels of HOMA-IR, BMI, total cholesterol (TC) and triglyceride (TG) in NAFLD patients. Downregulation of miR-129-5p regulates lipid metabolism and insulin sensitivity in NAFLD mice model.Conclusions: MiR-129-5p was up-regulated in NAFLD patients, and might be a potential diagnostic biomarker. The regulatory effect of miR-129-5p on NAFLD may function by regulating lipid accumulation and insulin sensitivity.
Comprehensive Proteomic Analysis of Exosomes Derived from Human Bone Marrow-, Adipose Tissue-, and Umbilical Cord- Mesenchymal Stem Cells
Authors: Wang Zhenggang , He Zhi-yi , Liang Shuang , Yang Qing , Cheng Peng , Chen An-min 
Published: September 2020

Abstract
Background: Mesenchymal stem cells (MSCs)-derived exosomes have shown comprehensive application prospects over the years. Despite performing similar functions, exosomes from different origins present heterogeneous characteristics and components; however, relative study remains scarce. Lacking of a valuable reference, researchers select source cells for exosome studies mainly based on accessibility and personal preference.Methods: In this study, exosomes secreted by MSCs derived from different tissues were isolated, by ultracentrifugation, and proteomics analysis was performed. A total of 1,014 proteins were detected using a label-free method. Results: Bioinformatics analysis revealed their shared function in the extracellular matrix receptor. Bone marrow-MSCs-derived exosomes showed superior regeneration ability, and adipose tissue-MSCs-derived exosomes played a significant role in immune regulation, whereas, umbilical cord-MSCs-derived exosomes were more prominent in tissue damage repair.Conclusions: This study systematically and comprehensively analyzes the human MSCs-derived exosomes via proteomics, which reveals their potential applications in different fields, so as to provide a reference for researchers to select optimal source cells in future exosome-related studies.
Management of pulmonary hypertension in secondary antiphospholipid syndrome
Authors: Elmogy Ahmed A , Gergis Michael , Hassan Ahmed , Hanna Irini S , Yacoub Magdi 
Published: September 2020

Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues. The extreme heterogeneity of the disease has led some investigators to propose that SLE represents a syndrome rather than a single disease. Antiphospholipidsyndrome (APS) is an autoimmune disease characterized by the occurrence of venous and/or arterial thrombosis and pregnancy morbidity in the presence of pathogenic autoantibodies known as antiphospholipid antibodies (aPL). APS may be associated with other diseases, mainly systemic lupus erythematosus (SLE). Different groups of pulmonary hypertension (PH) can complicate SLE due to various etiologies. One of the well-known established pathogenesis is chronic thromboembolic pulmonary hypertension (CTEPH). The presence of secondary APS in SLE patients further aggravate the condition due to recurrent venous thromboembolic showers to the pulmonary vasculature. Pulmonary endarterectomy (PEA) is the treatment of choice for CTEPH. The majority of patients experience substantial relief from symptoms and near normalization of hemodynamics. Patients who do not undergo PEA or suffer from persistent or recurrent PH after PEA (post-PEA PH) face a poor prognosis.
The haemodynamic assessment of patients with pulmonary arterial hypertension
Authors: Ghio Stefano 
Published: September 2020

[No abstract. Showing first paragraph of article]Right heart catheterization (RHC) has a crucial role in the management of patients with pulmonary hypertension (PH). Firstly, it is mandatory in subjects with the suspicion of PH to confirm the diagnosis. Secondly, it is strongly recommended in the follow-up of patients with confirmed pulmonary arterial hypertension (PAH) to evaluate drug efficacy and in case of clinical deterioration.In order to always perform a complete and correct RHC, clinicians carrying out the examination must be guided not only by technical recommendations, but also by the accurate knowledge of the different clinical issues which have to be addressed in these different situations.
Effect of silt content in filling sand on the geotubes dewatering performance by hanging bag tests
Authors: Man Xiaolei , Hu Shuigen , Wang Wansheng 
Published: September 2020

The dewatering performance of geotubes is affected by the silt content of filling sand, which limits the construction speed of geotubes. In order to evaluate the effect of silt content of filling sand on the dewatering performance of geotubes, a series of hanging bag tests were carried-out by varying filling sand with five different silt content. In the tests, the variation of the water loss, soil loss and soil particles grading with time were studied. And the relationship between the silt content and the rate of water loss was analyzed. The research results show that the dewatering process could be divided into three stages, when the powder content is more than 20 %. Otherwise, the dewatering process only includes two stages. Three different bell-shaped function relationships exist between the percentage content of silt particles, median particle size and non-uniformity coefficient with the rate of water loss respectively. Furthermore, the different relationships were simplified into 3 different linear functions correspondingly. The research results could be used as a reference for geotubes engineering practice.