bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticobasal Degeneration Misdiagnosed As Musculoskeletal Disease: A Challenging Diagnosis of Higher-Level Gait Disease
Authors: Onder Halil 
Published: September 2020

Abstract
Gait disorders are common in the elderly as there are various causes of neurological and non-neurological conditions. On the other hand, most of the gait parameters do change with advancing age which is identified as age-related physiological changes in gait. At this point, the discrimination between age-related physiological changes and gait disorders may be strictly challenging. After identifying gait as an abnormal pattern, classification of it and making the responsible pathophysiology also require high-level expertise in this regard. Herein, we present a rare patient with corticobasal degeneration (CBD) who had admitted initially due to complaints of gait problems. Over a long time, the patient had received the misdiagnosis of gait abnormality due to musculoskeletal problems by multiple physicians. However, the detailed neurological exam showed a higher level gait disorder (HLGD). Further investigations at this point yielded the diagnosis of CBD.
An Unusual Occurrence of Trifluoperazine-Induced Nystagmus in Persistent Hallucinatory Disorder—A Case Report
Authors: Muthuramalingam Avin , Chandrasekaran Vigneshvar , Subramanian Karthick 
Published: September 2020

Abstract
Trifluoperazine is a conventional antipsychotic whose use has been limited with the arrival of relatively new atypical antipsychotics. However, conventional antipsychotics are utilized in the management of psychiatric illnesses comorbid with metabolic disorders such as diabetes or dyslipidemia. Though trifluoperazine has been known to cause extrapyramidal symptoms, rarely ophthalmic symptoms manifest. Here, we discuss the rare occurrence of newly-emergent nystagmus in an individual with persistent hallucinatory disorder and comorbid diabetes mellitus treated with trifluoperazine.
A mouse tissue atlas of small noncoding RNA
Authors: Isakova Alina , Fehlmann Tobias , Keller Andreas , Quake Stephen R. 
Published: September 2020

Significance
We report a systematic unbiased analysis of small RNA molecule expression in 11 different tissues of the model organism mouse. We discovered uncharacterized noncoding RNA molecules and identified that ∼30% of total noncoding small RNA transcriptome are distributed across the body in a tissue-specific manner with some also being sexually dimorphic. Distinct distribution patterns of small RNA across the body suggest the existence of tissue-specific mechanisms involved in noncoding RNA processing.
An integrated assessment of the global virtual water trade network of energy
Authors: Peer Rebecca A M , Chini Christopher M 
Published: September 2020

Abstract
The global trade of energy allows for the distribution of the world’s collective energy resources and, therefore, an increase in energy access. However, this network of trade also generates a network of virtually traded resources that have been used to produce energy commodities. An integrated database of energy trade water footprints is necessary to capture interrelated energy and water concerns of a globalized economy,and is also motivated by current climate and population trends. Here, we quantify and present the virtual water embedded in energy trade across the globe from 2012 to 2018, building on previous water footprinting and energy virtual water trade studies to create an integrated database. We use data from the United Nations Comtrade database and combine several literature estimates of water consumption of energy commodities to generate the global virtual water trade network. Results include a comprehensive database of virtual water trade for energy at the country level, greatly expanding the literature availability on virtual water trade. The total volume of virtual water trade increased 35% from 157 km3 in 2012 to 211 km3 in 2018. The global trade of oil and fuelwood are consistent drivers of virtual water trade over time, whereas coal, hydrocarbons, and charcoal collectively contribute less than 4% of total virtual water trade between 2012 and 2018. Electricity, despite a less dense trade network constrained by infrastructure, contributes notably to virtual water trade, driven largely by water use for hydroelectricity. This study develops an integrated assessment of previous virtual water studies to estimate global virtual water trade of energy, creating a platform for future global studies.
Wearable pressure sensor for athletes’ full-range motion signal monitoring
Authors: Kaiqiang Wu , Xingyang Li 
Published: September 2020

Abstract
In order to real-time grasp of various physiological signals of athletes during sports, a high-performance flexible pressure sensor that can monitor various physiological signals and human motion was designed. Porous polydimethylsiloxane (PDMS) foam prepared by the sacrificial template method and graphene as raw materials were used to prepare a flexible pressure sensor with wide working range (0–100 kPa), ultra-high sensitivity (the average sensitivity in the range of 0–30 kPa is 17.9 kPa−1, the sensitivity in the range of 30–100 kPa reaches 79 kPa−1), fast response ability (response time is 20 ms) and long-term work stability (more than 10 000 cycles). The excellent performance of this pressure sensor depends on the use of PDMS foam with a high elastic modulus and the graphene loading level is controlled to an appropriate ratio. Finally, we used the conductive porous PDMS foam based flexible pressure sensor to demonstrate accurate and real-time monitoring of athletes’ tiny physiological signals (including pulse and electrocardiograph signals), vocalization and facial emotions, as well as violent joint and limb movements (including joint bending, walking, squats, jogging, and jumping), showing the potential in coaching athletes.
The Digital Afterlife of Nineteenth-Century Black Writing: Response to Genealogies of Black Modernity
Authors: Senchyne Jonathan 
Published: September 2020

Abstract
This response to the forum on the nineteenth-century genealogies of Black modernity explores how nineteenth-century racial and publication contexts continue to shape the digital circulation and digital afterlife of authors. A born-digital publication of a work by George Moses Horton reveals how nineteenth-century racial paratexts re-emerge in metadata and algorithmic capitalism.
When Horton is hailed by a data marketing company seeking to claim him as an asset, when his writing is routed through or claimed by white editors and (re)printers (myself included), and when his work is circulated in networks and spaces far beyond his own, the nineteenth-century conditions that structured Horton’s life and writing are revealed to shape his digital afterlife.
ChemFLuo: a web-server for structure analysis and identification of fluorescent compounds
Authors: Yang Zi-Yi , Dong Jie , Yang Zhi-Jiang , Yin Mingzhu , Jiang Hong-Li , Lu Ai-Ping , Chen Xiang , Hou Ting-Jun , Cao Dong-Sheng 
Published: September 2020

AbstractBackgroundFluorescent detection methods are indispensable tools for chemical biology. However, the frequent appearance of potential fluorescent compound has greatly interfered with the recognition of compounds with genuine activity. Such fluorescence interference is especially difficult to identify as it is reproducible and possesses concentration-dependent characteristic. Therefore, the development of a credible screening tool to detect fluorescent compounds from chemical libraries is urgently needed in early stages of drug discovery.ResultsIn this study, we developed a webserver ChemFLuo for fluorescent compound detection, based on two large and high-quality training datasets containing 4906 blue and 8632 green fluorescent compounds. These molecules were used to construct a group of prediction models based on the combination of three machine learning algorithms and seven types of molecular representations. The best blue fluorescence prediction model achieved with balanced accuracy (BA) = 0.858 and area under the receiver operating characteristic curve (AUC) = 0.931 for the validation set, and BA = 0.823 and AUC = 0.903 for the test set. The best green fluorescence prediction model achieved the prediction accuracy with BA = 0.810 and AUC = 0.887 for the validation set, and BA = 0.771 and AUC = 0.852 for the test set. Besides prediction model, 22 blue and 16 green representative fluorescent substructures were summarized for the screening of potential fluorescent compounds. The comparison with other fluorescence detection tools and theapplication to external validation sets and large molecule libraries have demonstrated the reliability of prediction model for fluorescent compound detection.ConclusionChemFLuo is a public webserver to filter out compounds with undesirable fluorescent properties, which will benefit the design of high-quality chemical libraries for drug discovery. It is freely available at http://admet.scbdd.com/chemfluo/index/.
Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation
Authors: Coşkun Abdurrahman , Sandberg Sverre , Unsal Ibrahim , Cavusoglu Coskun , Serteser Mustafa , Kilercik Meltem , Aarsand Aasne K 
Published: September 2020

Abstract

Background
The concept of personalized medicine has received widespread attention in the last decade. However, personalized medicine depends on correct diagnosis and monitoring of patients, for which personalized reference intervals for laboratory tests may be beneficial. In this study, we propose a simple model to generate personalized reference intervals based on historical, previously analyzed results, and data on analytical and within-subject biological variation.

Methods
A model using estimates of analytical and within-subject biological variation and previous test results was developed. We modeled the effect of adding an increasing number of measurement results on the estimation of the personal reference interval. We then used laboratory test results from 784 adult patients (&gt;18 years) considered to be in a steady-state condition to calculate personalized reference intervals for 27 commonly requested clinical chemistry and hematology measurands.

Results
Increasing the number of measurements had little impact on the total variation around the true homeostatic set point and using ≥3 previous measurement results delivered robust personalized reference intervals. The personalized reference intervals of the study participants were different from one another and, as expected, located within the common reference interval. However, in general they made up only a small proportion of the population-based reference interval.

Conclusions
Our study shows that, if using results from patients in steady state, only a few previous test results and reliable estimates of within-subject biological variation are required to calculate personalized reference intervals. This may be highly valuable for diagnosing patients as well as for follow-up and treatment.
Identification of the citrate exporter Cex1 ofYarrowia lipolytica
Authors: Erian Anna Maria , Egermeier Michael , Rassinger Alice , Marx Hans , Sauer Michael 
Published: September 2020

ABSTRACTYarrowia lipolytica is a yeast with many talents, one of them being the production of citric acid. Although the citrate biosynthesis is well studied, little is known about the transport mechanism by which citrate is exported. To gain better insight into this mechanism, we set out to identify a transporter involved in citrate export of Y. lipolytica. A total of five proteins were selected for analysis based on their similarity to a known citrate exporter, but neither a citrate transport activity nor any other phenotypic function could be attributed to them. Differential gene expression analysis of two strains with a distinct citrate productivity revealed another three putative transporters, one of which is YALI0D20196p. Disrupting YALI0D20196g in Y. lipolytica abolished citrate production, while extrachromosomal expression enhanced citrate production 5.2-fold in a low producing wildtype. Furthermore, heterologous expression of YALI0D20196p in the non-citrate secreting yeast Saccharomyces cerevisiae facilitated citrate export. Likewise, expression of YALI0D20196p complemented the ability to secrete citrate in an export-deficient strain of Aspergillus niger, confirming a citrate export function of YALI0D20196p. This report on the identification of the first citrate exporter in Y. lipolytica, termed Cex1, represents a valuable starting point for further investigations of the complex transport processes in yeasts.
An infinitary axiomatization of dynamic topological logic
Authors: Chopoghloo Somayeh , Moniri Morteza 
Published: September 2020

Abstract
Dynamic topological logic ($\textsf{DTL}$) is a multi-modal logic that was introduced for reasoning about dynamic topological systems, i.e. structures of the form $\langle{\mathfrak{X}, f}\rangle $, where $\mathfrak{X}$ is a topological space and $f$ is a continuous function on it. The problem of finding a complete and natural axiomatization for this logic in the original tri-modal language has been open for more than one decade. In this paper, we give a natural axiomatization of $\textsf{DTL}$ and prove its strong completeness with respect to the class of all dynamic topological systems. Our proof system is infinitary in the sense that it contains an infinitary derivation rule with countably many premises and one conclusion. It should be remarked that $\textsf{DTL}$ is semantically non-compact, so no finitary proof system for this logic could be strongly complete. Moreover, we provide an infinitary axiomatic system for the logic ${\textsf{DTL}}_{\mathcal{A}}$, i.e. the $\textsf{DTL}$ of Alexandrov spaces, and show that it is strongly complete with respect to the class of all dynamical systems based on Alexandrov spaces.
Preventive Efficacy of Tenofovir/Emtricitabine Against Severe Acute Respiratory Syndrome Coronavirus 2 Among Pre-Exposure Prophylaxis Users
Authors: Ayerdi Oskar , Puerta Teresa , Clavo Petunia , Vera Mar , Ballesteros Juan , Fuentes Manuel Enrique , Estrada Vicente , Rodríguez Carmen , Del Romero Jorge ,   Sandoval Study Group, Del Romero Jorge , Rodríguez Carmen , Puerta Teresa , Clavo Petunia , Vera Mar , Ballesteros Juan , Lejarraga Clara , Fernández Nuria , Hurtado Estefanía , García Mónica , González Montserrat , Jerez Natividad , Alcudia Florencia , Jiménez Maria Teresa , Torres Elisa , de Domingo Iria , Lázaro Ruth , Raposo Montserrat , Ayerdi Oskar , Del Romero Jorge , Rodríguez Carmen , Puerta Teresa , Clavo Petunia , Vera Mar , Ballesteros Juan , Lejarraga Clara , Fernández Nuria , Hurtado Estefanía , García Mónica , González Montserrat , Jerez Natividad , Alcudia Florencia , Jiménez Maria Teresa , Torres Elisa , de Domingo Iria , Lázaro Ruth , Raposo Montserrat , Ayerdi Oskar 
Published: September 2020

Abstract

Background
The preventive effect that tenofovir/emtricitabine (FTC) could have against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human immunodeficiency virus-negative people is unknown. The objective of this study was to analyze the seroprevalence and clinical manifestations of COVID-19 among users of pre-exposure prophylaxis (PrEP), disoproxil fumarate/FTC (TDF/FTC), or tenofovir alafenamide (TAF)/FTC and to compare it to that of a control group.

Methods
An observational descriptive study of the seroprevalence of antibodies for SARS-CoV-2 among men who have sex with men and transgender women without use of PrEP (Group 1; n = 250) and PrEP users with TDF/FTC (n = 409) or TAF/FTC (n = 91) (Group 2; n = 500) was conducted from May11, 2020 to June 27, 2020. All participants were provided with a structured questionnaire that collected information on the variables to be analyzed, and testing for immunoglobulin G antibodies to SARS-CoV-2 (chemiluminescent microparticle immunoassay) was then carried out.

Results
The seroprevalence of SARS-CoV-2 was 9.2% (95% confidence interval [CI], 5.9–13.5) in the group without PrEP and 15.0% (95% CI, 12.0–18.4) in the group with PrEP (P = .026). Among users of TDF/FTC it was 14.7% (95% CI, 11.4–18.5), and in users of TAF/FTC it was 16.5% (95% CI, 9.5–25.7) (P = .661). In those who tested positive for SARS-CoV-2 and receiving PrEP, 57.4% manifested symptoms, compared with 78.3% in the control group (P = .070). In users of TDF/FTC the figure was 53.3% and in users of TAF/FTC the figure was 73.3% (P = .100). The duration of symptoms was 11.5 days in the control group, 9.0 days in PrEP users (P = .116), 7.0 days in users of TDF/FTC, and 13.0 days in users of TAF/FTC (P = .100).

Conclusions
Users of PrEP, TDF/FTC, or TAF/FTC presented a higher seroprevalence to SARS-CoV-2 than the control group. No statistically significant differences were found in relation to clinical manifestations. The PrEP users should use the same prevention measures as those indicated for the general population.
BENCHMARKING OF A NEW AUTOMATIC CT RADIATION DOSE CALCULATOR
Authors: Akyea-Larbi Kofi Okyere , Tetteh Mercy Afadzi , Martinsen Anne Catrine T , Hasford Francis , Inkoom Stephen , Jensen Kristin 
Published: September 2020

Abstract
Information on patient radiation dose is essential to meet the radiation protection regulations and the demands of dose optimization. Vendors have developed different tools for patient dose assessment for radiological purposes. In this study, estimated effective doses derived from a new image-based software tool (DoseWatch, GE Healthcare) was benchmarked against the corresponding doses from a dose calculator (CT-Expo, SASCRAD) and a conversion coefficient method. Dose data from 150 adult patients (66 male and 84 female), who underwent CT head, abdominopelvic or chest examinations, were retrospectively collected using DoseWatch. Effective dose estimated by DoseWatch was significantly lower than that of CT-Expo and DLP-E (k) (p ≤ 0.001). For the organ doses, DoseWatch resulted in lower dose than CT-Expo for all the organs with the exception of testis (p ≤ 001) and eye lenses (p ≤ 0.026).
Failing: Nursing Student Perceptions and Insights for Success
Authors: Owen Amy McBeth 
Published: September 2020

Abstract
Nursing student success is important to students, faculty, higher education, and health care as the nursing shortage continues. However, baccalaureate nursing graduation rates average 80 to 84 (National League for Nursing, n.d.; Texas Center for Nursing Workforce Studies, 2017). Research exploring increased student success is attributed to competitive admission of students highly successful in prerequisite coursework. There is a gap in the literature regarding students’ experiences of failure in didactic nursing courses. This article explores why previously successful students experience didactic failure in BSN course.
An Empowerment Model for Individuals with Chronic Tinnitus
Authors: Dauman Nicolas , Dauman René 
Published: September 2020

Objective:
This qualitative study sought to construct a model of empowerment for clinical implementation, based on the first-hand experience of a sample of individuals with chronic tinnitus.

Design:
The study was conducted in accordance with the inductive approach to data in classic grounded theory (GT). GT aims to build a model of behavior that accounts for the main concern of individuals and how they strive to resolve it. Twenty-one participants with chronic tinnitus (10 females, 11 males, age 31–85, mean: 57.6 years, mean duration of tinnitus: 12 years) were recruited through the patient association France Acouphènes and ENT consultations. Open-ended, tape-recorded interviews addressed the variation in the intrusiveness of tinnitus in daily life. A constant comparison analysis was undertaken to identify a core category and to distinguish stages in behavioral changes toward the tolerance of tinnitus.

Results:
Participants’ main concern was to limit the intrusiveness of tinnitus day in, day out. They continuously had to handle tinnitus-induced frustration, which was found to be the core category of the analysis accounting for how all the participants tried to deal with the condition. The more they managed to handle their frustration, the better they coped with the condition. Three behavior patterns were identified as facilitating the ongoing management of tinnitus-induced frustration: (1) searching for perspective upon tinnitus; (2) maintaining order in perception despite its interference; and (3) alleviating conflict arising from social interactions. A model of empowerment is presented that is based on four stages toward tolerance of tinnitus. They are dominated by lack of perspective upon tinnitus (circuit 1), preservation of energy through attempts to control its intrusiveness (circuit 2), attempts to detach oneself from the interference of tinnitus through constant activities (circuit 3), and self-induced relief through the fulfillment of meaningful goals (circuit 4).

Conclusion:
Tolerance of tinnitus requires finding balance between limiting one’s social participation and spontaneity in carrying out meaningful activities. Tolerance can be enhanced by the preservation of one’s energy and the mediating role of enjoyment through the fulfillment of gratifying goals. In patient counseling, it is essential to address the individual’s desire for direct relief from tinnitus through its elimination. Individuals should be made aware that such a desire will likely be thwarted, resulting in the worsening of intrusiveness. Improvement in tolerance is accompanied by the attenuation of niggling self-awareness, a change that is typical of full commitment with valued goals and that helps in alleviating the interference of tinnitus. By understanding the role of frustration, individuals may develop a sense of responsibility in dealing with disabling tinnitus.
Dermatologists' Perceptions and Confidence in Cosmetic Care for Male Patients
Authors: Shah Payal , Cartron Alexander M. , Roman Jorge , Zampella John 
Published: September 2020

BACKGROUND
Despite a growing interest in nonsurgical cosmetic procedures in men, the utilization of aesthetic treatments remains comparatively low, suggesting the presence of barriers to care.

OBJECTIVE
To describe barriers to cosmetic intervention for male patients from the perspective of dermatologists.

MATERIALS AND METHODS
An anonymous, online survey was distributed through a listserv made available by the American Academy of Dermatology.

RESULTS
Dermatologist respondents perceived a low utilization of cosmetic services in male patients (5%) and a lack of opportunity (72.3%) to provide such services. Respondents also perceived a lack of sufficient education/training (40.9%), experience (20.5%), and a lack of evidence in the field (20.5%) for dermatologists as potential barriers to cosmetic care for male patients. Presence of targeted messaging and in-office educational materials for male patients was found to be associated with increased utilization of cosmetic treatments by male patients (p = .012, p = .012, respectively). Dermatologists reported strong confidence in delivering various noninvasive cosmetic treatments to male patients.

CONCLUSION
Despite dermatologists' reported confidence in performing cosmetic procedures in men, many perceive insufficient education/training and experience with this population which may create barriers to cosmetic care for male patients. Increasing educational materials and targeted messaging to male patients may decrease barriers for patients to receive desired cosmetic care.