bluuebunny/crossref_metadata_2025_split huggingface dataset:
A VALORIZAÇÃO DA TERAPIA COMUNITÁRIA INTEGRATIVA COMO PRÁTICA EFETIVA DO SUS
Authors: Melo Vilma Felipe Costa de , Gomes Maria Isabel Nunes , Cavalcanti Larissa Nunes Figueiredo , Pereira Neirilanny Da Silva , Pereira Vagna Cristina Leite da Silva 
Published: January 2020

A Terapia Comunitária Integrativa (TCI) é uma prática de saúde mental, que aos poucos vem se consolidando no país como mais uma estratégia de cuidado nas doenças emocionais e mentais, promovendo dessa forma ações de atenção básica, visando a prevenção de doenças psíquicas e promovendo qualidade de vida. O objetivo deste trabalho além de prestar serviço de cuidado à comunidade é a valorização e reconhecimento dos bons resultados oferecidos por essa modalidade terapêutica por acadêmicos na área da saúde, bem como para firmação da Terapia Comunitária Integrativa como prática efetiva do SUS, na tentativa de minimizar as falhas encontradas na prática tradicional do modelo biomédico. Este trabalho consta de um relato de experiência, vivenciados por acadêmicas extensionistas do projeto: Rodas de terapia comunitária e resgate da auto-estima, das Faculdades Nova Esperança-PB. As visitas foram realizadas, semanalmente, durante o ano de 2018, com uma média de 15 usuárias, no Centro de Práticas Integrativas e Complementares (Canto da Harmonia). Consiste em um espaço aberto, onde ocorre a troca de experiências de vida de forma horizontal e circular, visando o alívio do sofrimento humano, através da partilha de experiências de vida entre os participantes. Observou-se que essa tecnologia de cuidado traz impacto positivo para a vida de pessoas que clamam por um espaço de acolhida, de valorização de experiências e de atenção, atuando como peça-chave no processo de promoção da saúde mental e prevenção do adoecimento psíquico.
Estimating Rupture Dimensions of Three Major Earthquakes in Sichuan, China, for Early Warning and Rapid Loss Estimates
Authors: Li Jiawei , Böse Maren , Wyss Max , Wald David J. , Hutchison Alexandra , Clinton John F. , Wu Zhongliang , Jiang Changsheng , Zhou Shiyong 
Published: January 2020

ABSTRACTLarge earthquakes, such as Wenchuan in 2008, Mw 7.9, Sichuan, China, provide an opportunity for earthquake early warning (EEW), as many heavily shaken areas are far (∼50  km) from the epicenter and warning times could be sufficient (≥5  s) to take preventive action. On the other hand, earthquakes with magnitudes larger than ∼M 6.5 are challenging for EEW because source dimensions need to be defined to adequately estimate shaking. Finite-fault rupture detector (FinDer) is an approach to identify fault rupture extents from real-time seismic records. In this study, we playback local and regional onscale strong-motion waveforms of the 2008 Mw 7.9 Wenchuan, 2013 Mw 6.6 Lushan, and 2017 Mw 6.5 Jiuzhaigou earthquakes to study the performance of FinDer for the current layout of the China Strong Motion Network. Overall, the FinDer line-source models agree well with the observed spatial distribution of aftershocks and models determined from waveform inversion. However, because FinDer models are constructed to characterize seismic ground motions (as needed for EEW) instead of source parameters, the rupture length can be overestimated for events radiating high levels of high-frequency motions. If the strong-motion data used had been available in real time, 50%–80% of sites experiencing intensity modified Mercalli intensity IV–VII (light to very strong) and 30% experiencing VIII–IX (severe to violent) could have been issued a warning with 10 and 5 s, respectively, before the arrival of the S wave. We also show that loss estimates based on the FinDer line source are more accurate compared to point-source models. For the Wenchuan earthquake, for example, they predict a four to six times larger number of fatalities and injured, which is consistent with official reports. These losses could be provided 1/2∼3  hr faster than if they were based on more complex inversion rupture models.
The Influence of Electronic Word of Mouth (E-WOM) and Travel Motivation toward the Interest in Visiting Lombok, Gender as a Mediator
Authors: Auliya Zakky Fahma , Auliya Zakky Fahma , Pertiwi Imanda Firmantyas Putri 
Published: January 2020

The background of this research is the decreased number of tourists, either domestic or foreign tourists, visiting Lombok, in which Lombok is a halal tourism destination in Indonesia. This research aims to analyze the influence of electronic word of mouth (e-WOM) and travel motivation toward the interest in visiting Lombok with gender as the mediator, using a purpose-sampling technique on its sample collection. The respondents of this research are university students in Surakarta. The number of questionnaires spread by the researcher is 316 samples and the samples that can be used are 264. This research uses the analysis tool of SPSS 22 with a scale of 1-5. The result shows that e-WOM and travel motivation influence the interest in visiting Lombok, while the influence with gender as the mediator shows that males have a bigger influence toward the use of e-WOM and travel motivation toward the interest of visiting Lombok
ASESMEN DINAMIS: IMPLEMENTASI TEKNIK ASESMEN DINAMIS BERBASIS PERKEMBANGAN MOTORIK HALUS DI KELOMPOK BERMAIN AISYIYAH MUTIARA UMMI KALASAN, YOGYAKARTA
Authors: Hayati Firdha , Asiah Asiah , Maulida Maulida 
Published: January 2020

AbstractThis research is motivated by a child who experiences the development of fine motor skills that are different from other children, so the teacher starts implement a dynamic assessment strategy. The purpose of this study is to describe how the teacher implements a dynamic assessment strategy based on fine motor development in children in KB Mutiara Ummi Kalasan. The research method used in this study uses interview techniques and documentation studies. Then the data were analyzed using Miles & Huberman analysis. The results show that the form of research used by the teacher concerned for children with the initials AA is the form of an observation checklist and portfolio worksheets. Children who have the initials AA have experienced fine motor development gradually, and the level of development of children is in the stage of developing (MB).Keywords: dynamic assessment, development, fine motor skills AbstrakPenelitian ini dilatarbelakangi oleh seorang anak yang mengalami perkembangan kemampuan motorik halus yang berbeda dengan anak lainnya, sehingga guru mulai mengimplementasikan strategi asesmen dinamis. Tujuan penelitian ini ialah untuk mendeskripsikan bagaimana guru mengimplementasikan strategi asesmen dinamis berbasis perkembangan motorik halus pada anak di KB Mutiara Ummi Kalasan. Metode penelitian yang digunakan pada penelitian ini menggunakan teknik wawancara dan studi dokumentasi. Kemudian data dianalisis menggunakan analisis Miles & Huberman. Hasil menunjukkan bahwa bentuk penelitian yang digunakan oleh guru yang bersangkutan untuk anak yang berinisial AA ialah bentuk penilaian observasi checklist dan lembar kerja portofolio. Anak yang berinisial AA telah mengalami perkembangan motorik halus secara bertahap, dan tingkat perkembangan anak berada pada tahap mulai berkembang (MB).Kata Kunci: asesmen dinamis, perkembangan, motorik halus.
Integrating Oral Health Screening Into Primary Care to Promote Dental Referrals in Maryland
Authors: Scherr Susan , Idzik Shannon , Williams David 
Published: January 2020

BackgroundVulnerable populations are more likely to present to non-dental healthcare locations with dental issues. Oral health screening in those settings, such as primary care, is an effective way to identify individuals with unmet oral health needs and facilitate dental referrals.ObjectiveTo implement and evaluate the integration of oral health screening at an outpatient transitional primary care clinic in Maryland.MethodsThe quality improvement project occurred over 12 weeks. The project leader obtained support from institutional stakeholders, collaborated with dentistry, provided evidence-based resources, and developed referral strategies. Patients received a pre-screen at registration. Primary care providers used an oral health assessment tool (OHAT) for further screening and/or gave a dental referral.ResultsApproximately 108 patients completed pre-screen: 73% had not seen dentist in the past 12 months; 12% had current oral problem or pain; 53% had no established dentist; <5% had a completed OHAT; 20% referred to existing dentist; 56% received dental resource listing.ConclusionsOral health disparity continues to exist among vulnerable populations.Implications for NursingOral screening by advanced practice nurses is an effective way to identify patients with unmet oral health needs and to promote dental referral.
Integrasi Pasar dan Pembentukan Harga Cabai Merah di Indonesia
Authors: Kustiari Reni , Sejati Wahyuning Kusuma , Yulmahera Riva 
Published: January 2020

<strong>English</strong><br />Red chili is one of the essential horticultural commodities because it is the main cooking spice for the Indonesian people. This paper discusses the integration of the red chili market in Indonesia using monthly price data for the period 2011-2016. Market integration is analyzed using Johansen cointegration models. The Engle-Granger (EG) causality test results show that producer prices and wholesale prices affect consumer prices, there is a one-way causal relationship. Therefore, the causality approach accepts the Law of One Price (LOP) hypothesis of red chili price. The results of the co-integration model show that the market for red chili is well integrated. Furthermore, variance decomposition analysis shows that Medan is the market leader for chili in Indonesia.<br /><br /><br /><strong>Indonesian</strong><br />Cabai merah adalah salah satu komoditas hortikultura yang penting karena merupakan bumbu masak utama bagi masyarakat Indonesia. Makalah ini membahas integrasi pasar cabai merah di Indonesia dengan menggunakan data harga bulanan periode 2011-2016. Integrasi pasar dianalisis dengan menggunakan Johansen kointegrasi model. Hasil uji kausalitas Engle-Granger (EG) menunjukkan bahwa harga produsen dan harga grosir mempengaruhi harga konsumen, ada hubungan kausal satu cara. Oleh karena itu, pendekatan kausalitas menerima hipotesis Hukum Satu Harga (LOP) komoditas cabai merah. Hasil dari model co-integration menunjukkan bahwa pasar cabai merah terintegrasi dengan baik. Selanjutnya, analisis variance decomposition menunjukkan bahwa Medan adalah pasar acuan (price leader) untuk harga cabai di indonesia.
Unbiased prediction modeling for discovery research in nonalcoholic fatty liver disease
Authors: Kartoun Uri , Aggarwal Rahul , Perer Adam , Park Yoonyoung , Zhang Ping , Luo Heng , Dey Sanjoy , Corey Kathleen , Ng Kenney 
Published: January 2020

Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent yet underdiagnosed and under-discussed disease. Given that NAFLD has not been explored sufficiently compared with other diseases, opportunities abound for scientists to discover new biomarkers (such as laboratory observations, current comorbidities, and behavioral descriptors) that can be linked to the development of conditions and complications that may develop at a later stage of the patient’s life.Methods: We analyzed IBM Explorys, a repository that contains electronic medical records (EMRs) of more than 60 million individuals. We used a classification algorithm that members of our group have previously validated to identify patients at a high probability for NAFLD. The algorithm identified more than 80,000 patients with a high probability for NAFLD who had at least 5 years of follow-up. We followed an unbiased approach for prediction modeling and applied standard statistical methods (such as logistic regression and bootstrapping) as well as Clinical Classifications Software (CCS) definitions to identify associations between a variety of covariates and disease outcomes.Results: Our methodology identified several thousand strongly statistically significant associations between covariates and outcomes in NAFLD. Most of the associations are known, but others may be new and require further investigation in subsequent studies.Conclusions: A discovery mechanism composed of standard statistical methods and applied on a large collection of EMRs confirmed known associations and identified potentially new associations that can act as biomarkers that might merit further research.
ATLANTIS: An adaptive multi-arm phase II trial of maintenance targeted therapy after chemotherapy in patients with metastatic urothelial cancer
Authors: Fulton Ben , Jones Robert , Powles Thomas , Crabb Simon , Paul James , Birtle Alison , Chowdhury Simon , Hussain Syed , Morris Anna , Soulis Eileen , Morrison Paula 
Published: January 2020

Abstract
Background Metastatic urothelial cancer (UC) is the eighth most common cause of cancer death in the UK. Standard first-line treatment, for most patients, is cytotoxic chemotherapy. Although UC is initially sensitive to chemotherapy, relapse is almost inevitable after which outcomes are poor, with median overall survival 8 months. There is, therefore, an urgent need for novel therapies to improve outcomes for this patient group. Methods ATLANTIS is a randomised phase II, adaptive design trial of maintenance therapy in biomarker defined subgroups of patients with advanced UC. The primary end-point is progression-free survival (PFS) and the study involves over 30 UK cancer centres. Discussion ATLANTIS is the first study in the UK to employ a precision medicine approach to UC patients for maintenance treatment. Agents with positive efficacy signal will proceed to randomised phase III trials to confirm activity of novel biologically stratified therapies in UC.
Altered staining patterns and expression level of Engrailed-2 in Benign prostatic hyperplasia and Prostate Cancer predict Prostatic disease progression
Authors: Li Qi , Shi Yibo , Sa Rigai , Hao Jun , Hu Jinhao , Xiao Mulun , Wang Chaoliang , Yan Liang , Qiao Baoping , Chen Guoxun 
Published: January 2020

Abstract
Background: Prostate cancer (PC) as a kind of malignant tumor, causes the most death of cancer among males. Successful curing of PC greatly relies on its diagnose in the early stage. Engrailed-2 (EN2), which has been confirmed being existed in the high level in the urine of PC patients. In this study, we determine if there were differences in the staining patterns and expression level of EN2 in benign prostatic hyperplasia (BPH) and PC.Methods: Immunohistochemical and RT-PCR analysis of the expression of EN2 was conducted in 25 PC and 25 BPH cases. EN2 monoclonal antibody against EN2 helix 3 was developed and its specificity was identified. The subcellular localization of endogenic and exogenous EN2 in three PC cell lines (LNCap, PC3, and DU145) was detected by immunofluorescence. Correlation among clinical indicators and EN2 immunohistochemical scores of these 25 PC and 25 BPH cases were analyzed and two representative PC cases with different EN2 expression were used to vividly illustrate the correlation between EN2 expression and PC clinical stage. Results: The results of western-blotting (WB) and immunofluorescence showed homemade EN2 monoclonal antibody could specifically bind endogenic and ectogenic EN2 protein in three different PC cell lines. Results of immunofluorescence showed the endogenic EN2 was generally expressed in the cytoplasm and ectogenic EN2 has mostly existed in the nucleus of three PC cell lines. Immunohistochemical staining of EN2 in PC was extremely higher than in BPH confirmed by RT-PCR. The staining areas were mostly nucleus and cytoplasm in BPH tissues but cytomembrane in PC tissues. The expression level of EN2 was positively correlated with the PC clinical stage. Conclusion: The EN2 monoclonal antibody we made could be used in immunohistochemistry to display the expression pattern of EN2 in BPH and PC. The staining patterns and expression level of EN2 in BPH and PC are different.
Spectrophotometric Analysis Evaluating Apical Microleakage in Retrograde Filling using GIC, MTA and Biodentine: An in-vitro study
Authors: Nepal Manisha , Shubham Snigdha , Tripathi Rupam , Khadka Jwolan , Kunwar Deepa , Gautam Vanita , Gautam Narayan 
Published: January 2020

Abstract
Background The present study compares the apical microleakage of three different root-end filling materials in which the retrograde cavity is prepared by two different burs. Methods Eighty extracted single rooted maxillary and mandibular premolars were taken. Root canal treatment was completed. Apical 3 mm of all the teeth were resected with diamond disk. The tooth were divided into four groups with two subgroups for each group containing 10 tooth (N= 10) as: Group IA (Negative Control and IB (Positive Control); Group IIA and IIB: Prepared with round carbide bur and round diamond bur respectively, filled with GIC; Group IIIA and IIIB: Prepared with round carbide bur and round diamond bur respectively, filled with MTA; Group IVA and IVB: Prepared with round carbide bur and round diamond bur, filled with Biodentine. After applying two coats of nail varnish leaving apical 3 mm (except for negative control group) all teeth were immersed in 2% methylene blue for 3 days and again in 65% nitric acid for next 3 days for extraction of dye. The obtained solution was then transferred to eppendorf tube and centrifuged in microcentrifuges at 14,000 revolution per minutes (RPM) for 5 minutes. Optical density or absorbance of the supernatant solution was measured with UV spectrophotometer at 550 nm. Results The absorbance of the supernatant solution after dye extraction is decreasing in the order of positive control> GIC> MTA> Biodentine> negative control group. The significant difference was observed between GIC and MTA (p=0.0001) and GIC and Biodentine (p=0.0001) with two different burs but statistically non-significant difference was observed between MTA and Biodentine with Carbide bur (p=0.127) and Diamond bur (p=0.496) respectively. Conclusions Within the limitations of the present study, it can be concluded that Biodentine and MTA showed less microleakage as compared to GIC. There is no significant difference between mean microleakage of MTA and Biodentine. However, the mean OD of the Biodentine was least of all evaluated materials. Preparation of the root-end using round carbide bur as well as round diamond burs showed comparable microleakage for all three filling materials.
Transcriptomic profiling and discovery of key genes involved in adventitious root formation from green cuttings of highbush blueberry (Vaccinium corymbosum L.)
Authors: An Haishan , Zhang Jiaying , Xu Fangjie , Jiang Shuang , Zhang Xueying 
Published: January 2020

Abstract
Background: Propagation of cuttings was mostly used in various plant species including blueberry, the special root characteristics of blueberry usually resulted in a difficulty in adventitious root (AR) formation. The AR formation was influenced by various factors, of which auxin was considered to play a center role, however little is known of the related regulative mechanisms. In this study, a comparative transcriptome analysis using RNA_seq of green cuttings treated with or without IBA was performed to identify candidate genes associated with IBA-induced AR formation. Results: Rooting phenotypes, especially rooting rate, was significantly promoted by exogenous auxin IBA application. Blueberry AR formation was a auxin-induced process, during which the adventitious root primordium initiation (rpi) began to be formed at 14 day after cutting (DAC), developed into root primordium (rp) at 21 DAC, then further developed to mature AR at 28 DAC and finally outgrowth from stem at 35 DAC. Higher IAA level and lower content of ABA and zeatin might facilitate the AR formation and development. A time series transcriptome analysis indentified 14970 differentially expressed genes (DEGs) during AR formation, of which there were 7467 up-regulated and 7503 down-regulated genes, respectively. Of these, about 35 candidate DEGs involved in auxin-induced pathway and AR formation were further identified, including 10 auxin respective genes ARFs and SAURs, 13 transcription factors LOB domain-containing protein (LBDs), 6 auxin transporter AUX22, LAX3/5 and PIN-like 6s (PIL6s) and 6 rooting-associated genes root meristem growth factor 9 (RGF9), lateral root primordium 1 (LRP1s), dormancy-associated protein homolog 3 (DRMH3). All these identified DEGs were highly up-regulated in certain stage during AR formation, indicating their potential roles in blueberry AR formation. Conclusions: The transcriptome profiling indicated candidate genes or major regulative factors that influence adventitious root formation in blueberry, and provided a comprehensive understanding of rooting mechanism of the auxin-induced AR formation from blueberry green cuttings.
Factors affecting the implementation of a whole school mindfulness program: A qualitative study using the Consolidated Framework for Implementation Research
Authors: Hudson Kristian , Lawton Rebecca , Hugh-Jones Siobhan 
Published: January 2020

Abstract
Background Preventing the onset of poor mental health in adolescence is an international public health priority. Universal, whole school preventative approaches are valued for their reach, and anti-stigmatising and resilience building principles. Mindfulness approaches to well-being have the potential to be effective when delivered as a whole school approach for both young people and staff. However, despite growing demand, there is little understanding of possible and optimal ways to implement a mindfulness, whole school approach (M-WSA) to well-being. This study aimed to identify the determinants of early implementation success of a M-WSA. We tested the capacity of the Consolidated Framework for Implementation Research (CFIR), to capture the determinants of the implementation of a mental health intervention in a school setting. Methods Key members of school staff (n=15) from five UK secondary schools attempting to implement a M-WSA were interviewed at two-time points, six months apart, generating a total of 30 interviews. Interviews explored participants’ attitudes, beliefs and experiences around implementing a M-WSA. Interview data were coded as CFIR constructs or other (non CFIR) factors affecting implementation. We also mapped school-reported implementation activity and perceived success over 30 months. Results The CFIR captured the implementation activities and challenges well, with 74% of CFIR constructs identifiable in the dataset. Of the 38 CFIR constructs, 11 appeared to distinguish between high and low implementation schools. The most essential construct was school leadership. It strongly distinguished between high and low implementation schools and appeared inter-related with many other distinguishing constructs. Other strongly distinguishing constructs included relative priority, networks and communications, formally appointed implementation leaders, knowledge and beliefs about the intervention, and executing. Conclusions The CFIR appears useful for assessing the implementation of mental health programs in UK secondary schools. Our findings suggest key implementation constructs that schools, commissioners and policy makers should focus on to promote successful early implementation of mental health programs. School leadership is a key construct to target at the outset.