bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factor structure of the University Personality Inventory in Japanese medical students
Authors: Sugawara Norio , Yasui-Furukori Norio , Sayama Masayuki , Shimoda Kazutaka 
Published: October 2020

Abstract
Background
The age of onset for most mental disorders is typically young adulthood, and the university setting is an important one for addressing mental health. The University Personality Inventory (UPI), which was developed to detect mental health problems in university students, is widely used for screening in Japan. However, there have been limited reports on the factor structure of the UPI based on a statistical test for binary indicators. The objective of this study was to assess the factor structure of the UPI in Japanese medical students.

Methods
This study examined the factor structure of the UPI in a sample of 1185 Japanese medical students at the time of university admission. The students were divided into subgroup A (n = 589) and subgroup B (n = 596) according to their year of university admission. Based on tetrachoric correlation coefficients, exploratory factor analysis (EFA) with promax rotation was applied to explore the dimensions of the inventory in subgroup A. Confirmatory factor analysis (CFA) was then conducted to verify the dimensions in subgroup B.

Results
The EFA with categorical variables yielded four factors in subgroup A. These factors, accounting for 48.9% of the variance, were labeled “Depression and Irritability”, “Anxiety and Persecutory Belief”, “Physical Symptoms”, and “Dependence”. The new four-factor structure showed good fit, and traditional factor structures previously reported were replicated via CFA. The internal consistency reliability was good for the overall UPI scale (alpha = 0.97) and for its four new factors (alpha = 0.83–0.91).

Conclusions
The UPI is a valid and reliable measure that can be used to assess symptoms across four dimensions of mental health in university settings. These findings offer a starting point for the detection of individuals with mental health problems.
Forgiveness of others and subsequent health and well-being in mid-life: a longitudinal study on female nurses
Authors: Long Katelyn N. G. , Worthington Everett L. , VanderWeele Tyler J. , Chen Ying 
Published: October 2020

Abstract
Background
Forgiveness is a concept of growing interest within psychology and of potential relevance to public health. While there has been increasing evidence suggesting positive associations between forgiveness of others and a range of psychosocial well-being and mental health outcomes, its associations with health behaviors and physical health are less clear.

Methods
This study used longitudinal data from the Nurses’ Health Study II (2008 Trauma Exposure and Post-traumatic Stress Supplementary Survey to 2015 questionnaire wave, N = 54,703), to conduct an outcome-wide analysis among a cohort of female nurses in the United States (age range: 43–64 years). The study prospectively examines the association between spiritually motivated forgiveness of others and a number of of subsequent psychosocial well-being, mental health, health behavior, and physical health outcomes in midlife. A set of linear, logistic, and Poisson regression models were used to regress each outcome on forgiveness in separate models. Sociodemographic factors, prior religious service attendance, and prior values of all outcome variables were controlled for wherever data were available. To account for multiple testing, we performed Bonferroni correction.

Results
Forgiveness was associated with subsequent improved psychosocial well-being and reduced psychological distress outcomes in a monotonic pattern. For instance, the top versus bottom level of forgiveness was associated with substantially higher levels of subsequent positive affect (β = 0.18, 95% CI: 0.15, 0.21) and social integration (β = 0.15, 95% CI: 0.13, 0.17), and was inversely associated with several indicators of subsequent psychological distress such as depressive symptoms (β = − 0.16, 95% CI: − 0.19, − 0.14). However, in this sample, there was little evidence that forgiveness was associated with health behaviors or physical health outcomes.

Discussion
This study suggests that forgiveness may be a health asset for promoting population mental health and psychosocial well-being, and moreover may also be understood as a good in itself. Further investigation on the dynamics between forgiveness and physical health is warranted to explore the discrepancy between the results here and some past research.
The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice
Authors: Shao Haozhen , Dong Lei , Feng Yanyan , Wang Chunhui , Tong Hongxuan 
Published: October 2020

Abstract
Background
Cantharidin (CTD) is a compound which have the potential to be exploited as an antitumor drug, and it has been demonstrated antitumor effects in a variety of cancers. However, the use is limited due to its severe toxicity. It has reported that it can induce fatal cardiac arrhythmias. Fortunately, we found that L-glutamine can alleviate cardiac toxicity caused by cantharidin in mice.

Methods
To investigate the protective effect of L-glutamine, we used a high dose of cantharidin in mice to create a model of cardiotoxicity. In the experimental mice, glutamine was given orally half an hour before they were administrated with cantharidin. The mice of control group were intraperitoneally injected with DMSO solution. The general state of all mice, cardiac mass index, electrocardiogram change and biological markers were determined. Hematoxylin-eosin staining (HE staining) of heart tissue was carried out in each group to reflect the protective effect of glutamine. To investigate the mechanisms underlying the injury and cardio-protection, multiple oxidative stress indexes were determined and succinate dehydrogenase activity was evaluated.

Result
The results showed that L-glutamine (Gln) pretreatment reduced weight loss and mortality. It also decreased the biological markers (p < 0.05), improved electrocardiogram and histological changes that CTD induced cardiotoxicity in mice. Subsequently, the group pretreated with L-glutamine before CTD treatment increases in MDA but decreases in SOD and GSH, in comparison to the group treated with CTD alone. Besides, succinate dehydrogenase activity also was improved when L-glutamine was administrated before cantharidin compared to cantharidin.

Conclusions
This study provided evidence that L-glutamine could protect cardiac cells against the acute cantharidin-induced cardiotoxicity and the protective mechanism of glutamine may be related to the myocardial cell membrane or the tricarboxylic acid cycle in the mitochondria.
The treatment of microbubble disease of 20th century cellulose acetate microfilm: application of ethyl cellulose and microrepair method
Authors: Jia Zhihui , Li Jing , Li Yuhu , Qi Yunpeng , Hu Daodao , Xing Huiping , Chao Xiaolian 
Published: October 2020

Abstract
Microbubble disease observed in cellulose acetate microfilm is accompanied by the production of vinegar syndrome, which affects the image integrity. In the present study, samples of cellulose acetate microfilm with microbubble disease were selected to investigate potential treatment methods. Samples were sourced from the Republic of China (AD 1912–1949) microfilm collections held in the Second Historical Archives of China. A combination of optical microscopy and a stainless-steel needle was used to remove plasticizer exudation within microbubbles. The plasticizer was effectively removed by infiltrating butan-1-ol into the microbubble from a small hole made by the stainless-steel needle. SEM and confocal microscopy were used to study the morphology and roughness of the internal surface of the microbubbles. It was found that the blurry image could be attributed to light scattering from the rough surface. Ethyl cellulose was used to fill the interior of the microbubble to obtain a clearer image. To determine the protective potential of this filling material, the chemical and mechanical properties of coated film after dry heat, hygrothermal and UV accelerated ageing were measured. Based on the above-mentioned results, it is encouraging that a new microrepair method and its corresponding method are offered in film treatment work.
Linkage of alterations in systemic iron homeostasis to patients’ outcome in sepsis: a prospective study
Authors: Brandtner Anna , Tymoszuk Piotr , Nairz Manfred , Lehner Georg F. , Fritsche Gernot , Vales Anja , Falkner Andreas , Schennach Harald , Theurl Igor , Joannidis Michael , Weiss Günter , Pfeifhofer-Obermair Christa 
Published: October 2020

Abstract
Background
Sepsis, a dysregulated host response following infection, is associated with massive immune activation and high mortality rates. There is still a need to define further risk factors and laboratory parameters predicting the clinical course. Iron metabolism is regulated by both, the body’s iron status and the immune response. Iron itself is required for erythropoiesis but also for many cellular and metabolic functions. Moreover, iron availability is a critical determinant in infections because it is an essential nutrient for most microbes but also impacts on immune function and intravascular oxidative stress. Herein, we used a prospective study design to investigate the putative impact of serum iron parameters on the outcome of sepsis.

Methods
Serum markers of iron metabolism were measured in a prospective cohort of 61 patients (37 males, 24 females) with sepsis defined by Sepsis-3 criteria in a medical intensive care unit (ICU) and compared between survivors and non-survivors. Regulation of iron parameters in patients stratified by focus of infection and co-medication as well as association of the markers with sepsis severity scores and survival were investigated with linear and logistic regression corrected for sex and age effects.

Results
Positive correlations of increased serum iron and ferritin concentrations upon ICU admission with the severity of organ failure (SOFA score) and with mortality were observed. Moreover, high TF-Sat, elevated ferritin and serum iron levels and low transferrin concentrations were associated with reduced survival. A logistic regression model consisting of SOFA and transferrin saturation (SOFA–TF-Sat) had the best predictive power for survival in septic ICU patients. Of note, administration of blood transfusions prior to ICU admission resulted in increased TF-Sat and reduced survival of septic patients.

Conclusions
Our study could show an important impact of serum iron parameters on the outcome of sepsis. Furthermore, we identified transferrin saturation as a stand-alone predictor of sepsis survival and as a parameter of iron metabolism which may in a combined model improve the prediction power of the SOFA score.

Trial registration
The study was carried out in accordance with the recommendations of the Declaration of Helsinki on biomedical research. The study was approved by the institutional ethics review board of the Medical University Innsbruck (study AN2013-0006).
Surgery for colloid carcinoma of the pancreas with portal vein tumor thrombus: a case report
Authors: Udagawa Daisuke , Shimazu Motohide , Sakuragawa Tadayuki , Maruyama Shotaro , Uchi Yusuke , Miura Eisuke , Masugi Yohei , Sakamoto Michiie 
Published: October 2020

Abstract
Background
The portal vein is occasionally invaded by advanced malignant tumors in the pancreatic head region. However, pancreatic cancer rarely has portal vein tumor thrombi. We report a case of pancreatic cancer with a massive portal vein tumor thrombus undergoing pancreatoduodenectomy with combined resection of the portal vein.

Case presentation
A 71-year-old man visited a clinic with complaints of abdominal discomfort and vomiting. Gastroscopy showed a massive tumor in the duodenum. He was referred to our hospital for further examinations and treatment. The CT showed a low-density tumor with a maximum diameter of 10 cm located on the pancreas head. A tumor widely invaded the duodenum and had a 6-cm portal vein tumor thrombus. MRCP did not show obvious stenosis of the pancreatic duct due to tumor invasion. There were no findings suggesting distant metastases. Biopsy of the duodenum revealed adenocarcinoma. He was diagnosed with primary pancreatic cancer or duodenal cancer with portal vein tumor thrombus and underwent pancreatoduodectomy with resection and reconstruction of the portal vein. He suffered no postoperative complications and was discharged 2 months after surgery. The final histopathological diagnosis was pancreatic colloid carcinoma. He received adjuvant chemotherapy, but died 16 months after surgery.

Conclusions
Colloid carcinoma of the pancreas is rare, and pancreatic carcinoma seldom forms a portal vein tumor thrombus. We experienced a very rare case of pancreatic colloid carcinoma with portal vein tumor thrombus and performed radical resection of the pancreas and portal vein.
Laparoscopic repeat liver resection for hepatic epithelioid hemangioendothelioma
Authors: Terasaki Fumihiro , Yamamoto Yusuke , Sugiura Teiichi , Okamura Yukiyasu , Ito Takaaki , Ashida Ryo , Ohgi Katsuhisa , Uesaka Katsuhiko 
Published: October 2020

Abstract
Background
Optimal treatment for patients with hepatic epithelioid hemangioendothelioma (HEHE) remains unclear. Laparoscopic repeat liver resection (LR) is a minimally invasive and potentially effective surgical option for multiple HEHEs.

Case presentation
A 42-year-old woman with no relevant history was admitted for multiple liver tumors. Six tumors were observed on T2-weighted magnetic resonance imaging (MRI) including one in S2, two in S3, two in S7, and one in S8. Pathological evaluation of percutaneous tumor biopsy tissue suggested a diagnosis of HEHE and laparoscopic LR was planned. The procedure began with partial resection of S7 and partial resection of S8 and left lateral sectionectomy were performed. Another tumor was found intraoperatively on the surface of S6, necessitating removal by partial resection. Pathological evaluation of the resected tumor tissue from all seven tumors concurred with that of the preoperative biopsy. The patient was discharged on postoperative day 6 without any complications. A follow-up MRI 15 months after the primary surgery revealed one tumor each in S4, S6, and S8. Laparoscopic repeat LR was performed. The patient was discharged on postoperative day 5 without any complications. All three recurrent tumors were pathologically confirmed as HEHEs.

Conclusions
We successfully treated primary and recurrent HEHEs with laparoscopic LR, which is a reasonable minimally invasive procedure considering the possibility of multiple courses of liver surgery in patients with HEHE.
In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds
Authors: Abbasi Naghmeh , Lee Ryan S. B. , Ivanovski Saso , Love Robert M. , Hamlet Stephen 
Published: October 2020

AbstractBackgroundBiomaterial-based bone tissue engineering represents a promising solution to overcome reduced residual bone volume. It has been previously demonstrated that gradient and offset architectures of three-dimensional melt electrowritten poly-caprolactone (PCL) scaffolds could successfully direct osteoblast cells differentiation toward an osteogenic lineage, resulting in mineralization. The aim of this study was therefore to evaluate the in vivo osteoconductive capacity of PCL scaffolds with these different architectures.MethodsFive different calcium phosphate (CaP) coated melt electrowritten PCL pore sized scaffolds: 250 μm and 500 μm, 500 μm with 50% fibre offset (offset.50.50), tri layer gradient 250–500-750 μm (grad.250top) and 750–500-250 μm (grad.750top) were implanted into rodent critical-sized calvarial defects. Empty defects were used as a control. After 4 and 8 weeks of healing, the new bone was assessed by micro-computed tomography and immunohistochemistry.ResultsSignificantly more newly formed bone was shown in the grad.250top scaffold 8 weeks post-implantation. Histological investigation also showed that soft tissue was replaced with newly formed bone and fully covered the grad.250top scaffold. While, the bone healing did not happen completely in the 250 μm, offset.50.50 scaffolds and blank calvaria defects following 8 weeks of implantation. Immunohistochemical analysis showed the expression of osteogenic markers was present in all scaffold groups at both time points. The mineralization marker Osteocalcin was detected with the highest intensity in the grad.250top and 500 μm scaffolds. Moreover, the expression of the endothelial markers showed that robust angiogenesis was involved in the repair process.ConclusionsThese results suggest that the gradient pore size structure provides superior conditions for bone regeneration.
Concept and application of relaxing radial retinectomy for retinal detachment with advanced proliferative vitreo-retinopathy
Authors: Girsang Waldensius , Sari Dwi C. R. , Srigutomo Wahyu , Gondhowiardjo Tjahjono D. , Sasongko Muhammad B. 
Published: October 2020

Abstract
Purpose
To revisit the concept of retinectomy and the theory of mechanical forces on the retina occurring in rhegmatogenous retinal detachment (RRD) and to describe the potential application of radial retinectomy in RRD with advanced proliferative vitreoretinopathy (PVR).

Methods
A literature search was performed to identify all English language articles reporting the use of retinectomy for the management of RRD with PVR. We reviewed the theoretical background of mechanical forces occurring in RRD.

Results
Detachment of the retina from the retinal pigment epithelium (RPE)/choroid is influenced by disequilibrium of several physical forces: tangential forces on the epiretinal membrane $$\left( {T_{1} } \right)$$

T
1

and radial traction on the retina $$F_{R}$$

F
R

exceeding the retinal adhesion force to the RPE $$\left( {T_{1} \;\text{ + }F_{R} \;\text{ > }\;F_{A} } \right)\,\,$$

T
1

+

F
R

>

F
A

. PVR may exaggerate the amounts of tangential and radial forces ($$\left( {T_{1} } \right)$$

T
1

and $$F_{R}$$

F
R

) that pull the retina off. Relaxing radial retinectomy, by the nature of its cutting pattern, may theoretically decrease the amounts of both forces, therefore restoring the equilibrium between tensile and adhesive forces on the retinal surface $$\left( {T_{1} \;\text{ + }F_{R} \;\text{ = }\;F_{A} } \right)\,\,$$

T
1

+

F
R

=

F
A

.

Conclusion
Relaxing radial retinectomy may potentially be applied in RRD with advanced PVR but has rarely been reported to date. Future studies are needed to evaluate its outcomes and long-term complications.
Acceptability and outcomes of an individualized exergaming telePT program for veterans with multiple sclerosis: a pilot study
Authors: Chanpimol Shane , Benson Kimberly , Maloni Heidi , Conroy Susan , Wallin Mitchell 
Published: October 2020

Abstract
Background
Physical rehabilitation services are an important component of treatment for persons with multiple sclerosis (PwMS) to improve and maintain physical mobility. However, PwMS often have significant barriers to outpatient physical therapy (PT) services including mobility deficits and lack of transportation. The integration of exercise gaming (exergaming) and telehealth into clinical PT practices may overcome these barriers. The overarching purpose of this pilot study was to evaluate the acceptability and effects of an individualized telePT intervention using exergaming.

Methods
Ten individuals with multiple sclerosis (MS) completed a 12-week exergaming (Jintronix®) telerehabilitation intervention. In order to measure the acceptability of the telerehabilitation intervention, adherence was measured through the tablet-based rehabilitation software and each participant completed a satisfaction questionnaire. Clinical outcome measures were assessed at baseline and post-intervention. To evaluate the efficacy of this intervention, the following measures of physical function and fatigue were included; the Short Physical Performance Battery (SPPB), 25-Foot Walk (25FW), Modified Fatigue Impact Scale (MFIS), Multiple Sclerosis Walking Scale-12 (MSWS), and the 2-Minute Walk Test (2MWT). Clinical outcomes were analyzed using the Sign test and Wilcoxon signed rank test. All other data were evaluated using descriptive statistics.

Results
After the intervention, participants demonstrated significant improvements in ambulation speed during the 25FW (p = 0.04) and ambulation distance during the 2MWT (p = 0.002). Statistically significant increases of SPPB total score (p = .04) and sub-scores were also found. Participants did not demonstrate significant changes in the MFIS (p = 0.31) or MSWS-12 (p = 0.06) after the intervention. Participants had a 58.3% adherence rate during the intervention and performed their exercise program an average of 2.5 times per week. All participants reported that they were either ‘satisfied or ‘very satisfied’ with their telerehabilitation experience, would use telerehabilitation again, and would recommend telerehabilitation to others.

Conclusion
This individualized telerehabilitation intervention which integrates exergaming and clinical video teleconferencing is acceptable to patients and may offer a viable alternative to traditional PT for PwMS.

Trial registration
NCT03655431, retrospectively registered on August 31st, 2018.
Comparative study between saddle block and local anesthesia on excision of pilonidal sinus by using ligaSure
Authors: Hussien Ayman Esmail , Fahim Amira Ibrahim 
Published: October 2020

Abstract
Background
The excision of the pilonidal sinus starts at 1833. Local, spinal, or general anesthetic procedures for the disease are widely used. The excision of the pilonidal sinus by using ligaSure reduces blood loss, reduces procedure time, and reduces patient length of stay. Therefore, the purpose of this study is to compare between local anesthesia and saddle block on the excision of the pilonidal sinus by using ligaSure, with respect to recovery time, postoperative complications, and patient satisfaction.

Results
Forty patients were analyzed; the mean time of anesthesia, operation time, and operating room time were showing highly significantly lower in group LA when compared to group SA (P value < 0.01). At the postoperative period, patients in group LA experienced less intense postoperative pain with prolonged time of the first request for analgesia than patients in other groups.

Conclusion
Local anesthesia has more efficacy in early start of anesthesia, early discharge from the hospital with prolonged analgesia, strong hemostasis, more patient satisfaction, and more than saddle block .Therefore, local anesthesia is considered as an alternative to the saddle block on the excision of the pilonidal sinus by using ligaSure.
Automating threat modeling using an ontology framework
Authors: Välja Margus , Heiding Fredrik , Franke Ulrik , Lagerström Robert 
Published: October 2020

AbstractThreat modeling is of increasing importance to IT security, and it is a complex and resource demanding task. The aim of automating threat modeling is to simplify model creation by using data that are already available. However, the collected data often lack context; this can make the automated models less precise in terms of domain knowledge than those created by an expert human modeler. The lack of domain knowledge in modeling automation can be addressed with ontologies. In this paper, we introduce an ontology framework to improve automatic threat modeling. The framework is developed with conceptual modeling and validated using three different datasets: a small scale utility lab, water utility control network, and university IT environment. The framework produced successful results such as standardizing input sources, removing duplicate name entries, and grouping application software more logically.