bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol
Authors: Poonai Naveen , Coriolano Kamary , Klassen Terry , Heath Anna , Yaskina Maryna , Beer Darcy , Sawyer Scott , Bhatt Maala , Kam April , Doan Quynh , Sabhaney Vikram , Offringa Martin , Pechlivanoglou Petros , Hickes Serena , Ali Samina 
Published: December 2020

IntroductionUp to 40% of orthopaedic injuries in children require a closed reduction, almost always necessitating procedural sedation. Intravenous ketamine is the most commonly used sedative agent. However, intravenous insertion is painful and can be technically difficult in children. We hypothesise that a combination of intranasal dexmedetomidine plus intranasal ketamine (Ketodex) will be non-inferior to intravenous ketamine for effective sedation in children undergoing a closed reduction.Methods and analysisThis is a six-centre, four-arm, adaptive, randomised, blinded, controlled, non-inferiority trial. We will include children 4–17 years with a simple upper limb fracture or dislocation that requires sedation for a closed reduction. Participants will be randomised to receive either intranasal Ketodex (one of three dexmedetomidine and ketamine combinations) or intravenous ketamine. The primary outcome is adequate sedation as measured using the Paediatric Sedation State Scale. Secondary outcomes include length of stay, time to wakening and adverse effects. The results of both per protocol and intention-to-treat analyses will be reported for the primary outcome. All inferential analyses will be undertaken using a response-adaptive Bayesian design. Logistic regression will be used to model the dose–response relationship for the combinations of intranasal Ketodex. Using the Average Length Criterion for Bayesian sample size estimation, a survey-informed non-inferiority margin of 17.8% and priors from historical data, a sample size of 410 participants will be required. Simulations estimate a type II error rate of 0.08 and a type I error rate of 0.047.Ethics and disseminationEthics approval was obtained from Clinical Trials Ontario for London Health Sciences Centre and McMaster Research Ethics Board. Other sites have yet to receive approval from their institutions. Informed consent will be obtained from guardians of all participants in addition to assent from participants. Study data will be submitted for publication regardless of results.Trial registration numberNCT0419525.
Online forward triage during the COVID-19 outbreak
Authors: Hautz Wolf E , Exadaktylos Aristomenis , Sauter Thomas C 
Published: December 2020

Health systems face major challenges during the COVID-19 pandemic with new information and challenges emerging daily and frequently changing guidelines. Online forward triage tools (OFTTs) provide useful information, direct patients and free physician resources.We implemented an OFTT targeted at the current pandemic, adapted the content and goals and assessed its effects. The OFTT was implemented on 2 March 2020 and modified regularly based on the revised testing criteria issued by the Swiss Federal Office of Public Health. After testing criteria liberalised, a chatbot tool was set up on 9 April 2020 to assess urgency of testing, referral to available testing sites and need for emergency care.In the first 40 days of the OFTT, there were more than 17 300 visitors and 69.8% indicated they would have contacted the healthcare system if the online test had not been available. During the initial week of operation, using the conservative testing strategy, 9.1% of visitors received recommendations to be tested, which increased to 36.0% of visitors after a change in testing criteria on 9 March 2020. Overall, since the implementation of the tool, 26.27% of all users of the site have been directed to obtain testing. The Chatbot tool has had approximately 50 consults/day.Setting up an OFTT should be considered as part of local strategies to cope with the COVID-19 pandemic. It may ease the burden on the healthcare system, reassure patients and inform authorities. To account for the dynamic development of the pandemic, frequent adaptation of the tool is of great importance. Further research on clinical outcomes of OFTT is urgently needed.
Validity of participants’ self-reported diagnosis for a work absence due to a mental health problem compared with physician-certified diagnosis for the same work absence among 709 Canadian workers
Authors: Gilbert-Ouimet Mahée , Trudel Xavier , Aubé Karine , Ndjaboue Ruth , Duchaine Caroline S , Blanchette Caty , Vézina Michel , Milot Alain , Brisson Chantal 
Published: December 2020

ObjectivesThis study assesses the validity of a self-reported mental health problem (MHP) diagnosis as the reason for a work absence of 5 days or more compared with a physician-certified MHP diagnosis related to the same work absence. The potential modifying effect of absence duration on validity is also examined.MethodsA total of 709 participants (1031 sickness absence episodes) were selected and interviewed. Total per cent agreement, Cohen’s kappa, sensitivity and specificity values were calculated using the physician-certified MHP diagnosis related to a given work absence as the reference standard. Stratified analyses of total agreement, sensitivity and specificity values were also examined by duration of work absence (5–20 workdays,>20 workdays).ResultsTotal agreement value for self-reported MHP was 90%. Cohen’s kappa value was substantial (0.74). Sensitivity was 77% and specificity was 95%. Absences of more than 20 workdays had a better sensitivity than absences of shorter duration. A high specificity was observed for both short and longer absence episodes.ConclusionThis study showed high specificity and good sensitivity of self-reported MHP diagnosis compared with physician-certified MHP diagnosis for the same work absence. Absences of longer durations had a better sensitivity.
Surgical factors associated with new-onset postoperative atrial fibrillation after lung resection: the EPAFT multicentre study
Authors: Crispi Vassili , Isaac Emmanuel , Abah Udo , Shackcloth Michael , Lopez Eileen , Eadington Thomas , Taylor Marcus , Kandadai Rammohan , Marshall Neil R , Gurung Anil , Rogers Luke J , Marchbank Adrian , Qadri Suhail , Loubani Mahmoud 
Published: December 2020

AbstractPurpose of the studyPostoperative atrial fibrillation (POAF) is a recognised complication in approximately 10% of major lung resections. In order to best target preoperative treatment, this study aimed at determining the association of incidence of POAF in patients undergoing lung resection to surgical and anatomical factors, such as surgical approach, extent of resection and laterality.Study designEvaluation of Post-operative Atrial Fibrillation in Thoracic surgery (EPAFT): a multicentre, population-based, retrospective, cross-sectional, observational study including 1367 patients undergoing lung resections between April 2016 and March 2017. The primary outcome was the presence of POAF following resection. POAF was defined as at least one episode of symptomatic or asymptomatic AF confirmed by ECG within 7 days from the thoracic procedure or prior to discharge from the hospital.ResultsPOAF was observed in 7.4% of patients: 3.1% in minor resection (video-assisted thoracoscopic surgery (VATS): 2.5%; thoracotomy: 3.8%), 9.0% in simple lobectomy (VATS: 7.3%, thoracotomy: 9.9%), 6.0% in complex resection (thoracotomy: 6.3%) and 11.4% in pneumonectomy. POAF was higher in left (4.0%) vs right (2.4%) minor resections, and in left (9.9%) vs right (8.3%) lobectomy, but higher in right (7.5%) complex resections, and the highest in right pneumonectomy (17.6%). No significant variations were observed as per sex, laterality or resected lobes. A positive univariable and multivariable association was observed for increasing age and increasing extent of resection, but not thoracotomy. Median (Q1–Q3) hospital stay was 9 (7–14) days in POAF and 5 (4–7) days in non-AF patients (p&lt;0.001), with an increased cerebrovascular accident burden (p&lt;0.001) and long-term mortality (p&lt;0.001).ConclusionsAmong patients undergoing lung resection, POAF was significantly associated with age, increasing invasiveness of approach and increasing extent of resection. In addition, POAF carried a significant long-term mortality rate and burden of cerebrovascular accident. Appropriate prophylaxis should be targeted at these groups.
Relative Fat Mass Index can be solution for obesity paradox in coronary artery disease severity prediction calculated by SYNTAX Score
Authors: Efe Süleyman Çağan , Karagoz Ali , Dogan Cem , Bayram Zubeyde , Kalkan Sedat , Altıntas Mehmet Sait , Yuksel Yasin , Karabag Turgut , Ayca Burak , Ozdemir Nihal 
Published: December 2020

ABSTRACTBackgroundThe relation between body mass index (BMI) and coronary artery disease (CAD) extension remains controversial. A new score was developed to estimate body fat percentage (BFP) known as Relative Fat Mass (RFM) Index. This study aimed to evaluate the value of RFM Index in predicting the severity of the CAD, compared with other anthropometric measurements.MethodsA total of 325 patients with chronic CAD were investigated. RFM, BFP, BMI and other anthropometric characteristics of patients were measured before angiography. CAD severity was determined by SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery trial (SYNTAX) Score. The association between SYNTAX Score and variables was evaluated using linear regression models. In order to compare the model performance, R-squared (R2), Akaike’s information criterion, Bayesian information criterion and root mean square error were used.ResultsUnivariate linear regression outcome variable, SYNTAX was used to determine whether there was any relationship between variables. Independent variables were included in the multivariable linear logistic regression models. The analysis showed that in model 1, RFM (β coefficient: 2.31 (0.90 to 3.71), p=0.001)), diabetes mellitus (β coefficient: 3.72 (1.67 to 3.76), p=0.004)), haemoglobin (β coefficient: −2.12 (−3.70 to −0.53), p=0.03) and age (β coefficient: 1.83 (0.29 to 3.37), p=0.02)) were statistically significant. The adjusted R2 values in model 1 were higher than model 2 (BFP) and model 3 (BMI) (0.155, 0.137 and 0.130, respectively), and χ2 values of RFM were higher than BFP and BMI (10.5, 3.4 and 1.0, respectively).ConclusionRFM Index is a more reliable and compatible marker of obesity in showing the severity of CAD compared to BMI.
A Simulation of the potential impact of restricting tobacco retail outlets around middle and high schools on tobacco advertisements
Authors: Obinwa Udoka , Pasch Keryn E , Jetelina Katelyn K , Ranjit Nalini , Perez Adriana , Perry Cheryl , Harrell Melissa 
Published: December 2020

ObjectiveTo examine (1) if tobacco retail outlets (TROs) closer to middle and high schools have more tobacco advertisements than TROs farther away and (2) the potential impact of two place-based tobacco control strategies on tobacco advertisements: a simulated ban of TROs (1) within 1000ft of schools and (2) within 500 ft of other TROs.MethodsTROs within half-mile of 53 middle and high schools in the four largest Metropolitan areas in Texas were audited for all tobacco marketing. ArcGIS was used for mapping and grouping TROs by distance from the schools and simulating the ban. Mean differences in the number of tobacco advertisements were examined with t-tests. Percentage reductions in tobacco advertisements were calculated after simulation of both bans, reported by school type and by location, product and flavour.ResultsTROs within 1000 ft of schools had significantly more tobacco advertisements as compared with TROs located within 1000-2000 ft (p=0.03) for all schools combined and middle schools. Simulation of the 1000 ft ban of TROs led to a slightly greater reduction in advertisements (19.4%) as compared with the 500 ft ban of TROs from other TROs (17.9%). The reduction in all advertisement types was greater around middle schools and greatest for e-cigarettes (23.6%).ConclusionStudents can be exposed to a great deal of tobacco advertising in TROs around their schools. The implementation of a 1000 ft ban of TROs, or at minimum a ban on tobacco advertising outside and within these outlets, is one way to prevent or reduce the use of tobacco among adolescents.
Comparing traditional and deep-learning techniques of kinematic reconstruction for polarization discrimination in vector boson scattering
Authors: Grossi M. , Novak J. , Kerševan B. , Rebuzzi D. 
Published: December 2020

AbstractMeasuring longitudinally polarized vector boson scattering in $$\mathrm {WW}$$
WW
channel is a promising way to investigate unitarity restoration with the Higgs mechanism and to search for possible physics beyond the Standard Model. In order to perform such a measurement, it is crucial to develop an efficient reconstruction of the full $$\mathrm {W}$$
W
boson kinematics in leptonic decays with the focus on polarization measurements. We investigated several approaches, from traditional ones up to advanced deep neural network structures, and we compared their abilities in reconstructing the $$\mathrm {W}$$
W
boson reference frame and in consequently measuring the longitudinal fraction $$\mathrm {W}_{\text {L}}$$

W
L

in both semi-leptonic and fully-leptonic $$\mathrm {WW}$$
WW
decay channels.
A minimal supersymmetric left-right model, dark matter and signals at the LHC
Authors: Huitu Katri 
Published: December 2020

AbstractThe left-right symmetric models extend the gauge group of the Standard Model enabling treatment of the left- and right-handed fermions in the same footing. The left-right symmetry requires the existence of right-handed neutrinos, leading naturally to non-zero masses for neutrinos. Here some aspects of a supersymmetric version of the left-right symmetric models are reviewed. Such models have many virtues, including possibility for dark matter without any new additional symmetry needed in order to have a stable lightest supersymmetric particle. In the model the lightest sneutrino or the lightest neutralino can form dark matter of the universe, at the same time fulfilling all the experimental constraints. The dark matter particle in the model can be very different from the dark matter typical in the minimal supersymmetric standard model. Specific signals for this kind of models at the LHC are also discussed.
Single-Electron Fault Tolerance in Quantum Cellular Automata Majority Gate
Authors: Sheibani Hamid , Rahimi Ehsan 
Published: December 2020

Quantum cellular automata (QCA) is a promising paradigm that enables performing arithmetic and logic operations at the nanoscopic scale. The QCA utilizes the configuration of electric charges in molecular scale quantum-dots to encode binary information. Defects are very likely to occur at the nanoscale and impact the operation of QCA devices. We concentrate on a specific fault, which is caused by impurities in materials used in packaging devices. These defects may cause a single-electron to tunnel outside a QCA cell and lead to a single-electron fault (SEF). Cosmic rays may also lead to a SEF. The three-input majority gate is the primary device in the QCA paradigm. In this paper, the effect of redundant cells on the fault tolerance of the majority gate is studied in the presence of a SEF. We present figures based on the number of redundant cells, their positions, and the clock method, which are essential in designing SEF-tolerant devices.
Proposed chronostratigraphic units for the Carboniferous and early Permian of the southwestern Gondwana margin
Authors: González Carlos R. , Díaz Saravia Pamela 
Published: December 2020

Abstract
The western Andean belt of Argentina displays a comprehensive record of the Carboniferous and earliest Permian rocks so extensive that it allows an exceptional reconstruction of the Late Paleozoic Ice Age of the southwestern margin of the South American Gondwana area. Severe endemism of the Gondwana biota during this period makes it difficult to achieve a precise correlation of these glacially influenced deposits with the coeval sequences of the palaeoequatorial belt, where the subdivisions of the International Chronostratigraphic Chart (ICC) are currently defined. The abundant palaeontological record available from the Upper Paleozoic deposits of central-western Argentina, central Patagonia and eastern Argentina makes it possible to recognize five successive faunal stages that allow a proper ordering of the sequences of this period. The proposed regional stages, and their assumed chronological position regarding the standards of the current ICC, are: the Malimanian (late Tournaisian), Barrealian (Mid-Carboniferous or Serpukhovian–Bashkirian), Aguanegrian (Upper Pennsylvanian), Uspallatian (Asselian–Tastubian?) and Bonetian (Sakmarian). This paper aims to reiterate former recommendations about the convenience of having regional reference units and suggests the consideration of the available faunal stages as possible chronostratigraphic subdivisions for the Carboniferous–early Permian of the southeastern margin of Gondwana.
ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly
Authors: Wu Shayi , Chen Miao , Huang Jiao , Zhang Feifei , Lv Zhaojie , Jia Yongxu , Cui Yu-Zhu , Sun Liang-Zhan , Wang Ying , Tang Ying , Verhoeft Krista R. , Li Yan , Qin Yanru , Lin Xiang , Guan Xin-Yuan , Lam Ka-On 
Published: December 2020

Abstract

The ubiquitous second messenger Ca2+ has long been recognized as a key regulator in cell migration. Locally confined Ca2+, in particular, is essential for building front-to-rear Ca2+ gradient, which serves to maintain the morphologic polarity required in directionally migrating cells. However, little is known about the source of the Ca2+ and the mechanism by which they crosstalk between different signaling pathways in cancer cells. Here, we report that calcium release–activated calcium modulator 2 (ORAI2), a poorly characterized store-operated calcium (SOC) channel subunit, predominantly upregulated in the lymph node metastasis of gastric cancer, supports cell proliferation and migration. Clinical data reveal that a high frequency of ORAI2-positive cells in gastric cancer tissues significantly correlated with poor differentiation, invasion, lymph node metastasis, and worse prognosis. Gain- and loss-of-function showed that ORAI2 promotes cell motility, tumor formation, and metastasis in both gastric cancer cell lines and mice. Mechanistically, ORAI2 mediated SOC activity and regulated tumorigenic properties through the activation of the PI3K/Akt signaling pathways. Moreover, ORAI2 enhanced the metastatic ability of gastric cancer cells by inducing FAK-mediated MAPK/ERK activation and promoted focal adhesion disassembly at rear-edge of the cell. Collectively, our results demonstrate that ORAI2 is a novel gene that plays an important role in the tumorigenicity and metastasis of gastric cancer.

Significance:
These findings describe the critical role of ORAI2 in gastric cancer cell migration and tumor metastasis and uncover the translational potential to advance drug discovery along the ORAI2 signaling pathway.
Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction
Authors: Zhao Hongmei , Yang Hongqin , Geng Chi , Chen Yang , Pang Junling , Shu Ting , Zhao Meijun , Tang Yaqin , Li Zhiwei , Li Baicun , Hou Cuiliu , Song Xiaomin , Wu Aoxue , Guo Xiaoxiao , Chen Si , Liu Bin , Yan Chen , Wang Jing 
Published: December 2020

Background:
Immunoglobulin E (IgE) belongs to a class of immunoglobulins involved in immune response to specific allergens. However, the roles of IgE and IgE receptor (FcεR1) in pathological cardiac remodeling and heart failure are unknown.

Methods:
Serum IgE levels and cardiac FcεR1 expression were assessed in diseased hearts from human and mouse. The role of FcεR1 signaling in pathological cardiac remodeling was explored in vivo by FcεR1 genetic depletion, anti-IgE antibodies, and bone marrow transplantation. The roles of the IgE-FcεR1 pathway were further evaluated in vitro in primary cultured rat cardiomyocytes and cardiac fibroblasts (CFs). RNA sequencing and bioinformatic analyses were used to identify biochemical changes and signaling pathways that are regulated by IgE/FcεR1.

Results:
Serum IgE levels were significantly elevated in patients with heart failure as well as in 2 mouse cardiac disease models induced by chronic pressure overload via transverse aortic constriction and chronic angiotensin II infusion. Interestingly, FcεR1 expression levels were also significantly upregulated in failing hearts from human and mouse. Blockade of the IgE-FcεR1 pathway by FcεR1 knockout alleviated transverse aortic constriction– or angiotensin II–induced pathological cardiac remodeling or dysfunction. Anti-IgE antibodies (including the clinical drug omalizumab) also significantly alleviated angiotensin II–induced cardiac remodeling. Bone marrow transplantation experiments indicated that IgE-induced cardiac remodeling was mediated through non–bone marrow–derived cells. FcεR1 was found to be expressed in both cardiomyocytes and CFs. In cultured rat cardiomyocytes, IgE-induced cardiomyocyte hypertrophy and hypertrophic marker expression were abolished by depleting FcεR1. In cultured rat CFs, IgE-induced CF activation and matrix protein production were also blocked by FcεR1 deficiency. RNA sequencing and signaling pathway analyses revealed that transforming growth factor-β may be a critical mediator, and blocking transforming growth factor-β indeed alleviated IgE-induced cardiomyocyte hypertrophy and cardiac fibroblast activation in vitro.

Conclusions:
Our findings suggest that IgE induction plays a causative role in pathological cardiac remodeling, at least partially via the activation of IgE-FcεR1 signaling in cardiomyocytes and CFs. Therapeutic strategies targeting the IgE-FcεR1 axis may be effective for managing IgE-mediated cardiac remodeling.