bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between plasma levels of Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters and carotid atherosclerosis in patients with combined hypertension and cerebral infarction
Authors: ji mingde , wang xueyan , zhu xiaofei , gu wanjian , zhuo meng , yang xuewen 
Published: December 2019

Abstract
Background: To observe the correlation between Lp-PLA2, Hcy, CRP, Lp(a), AT-III, and TEG parameters and carotid atherosclerosis with combined hypertension and cerebral infarction and evaluate their value in risk determination.Methods: Patients with primary hypertension were selected as subjects and divided into 2 groups based on cerebral infarction: simple hypertension group and hypertension combined with cerebral infarction group. The differences of Lp-PLA2, Hcy, CRP, Lp(a), AT-Ⅲ, and TEG were compared. Spearson correlation and multivariate logistic regression model were used to analyze the correlation. A ROC curve was used to analyse the value of a single item and their combination for the determination of carotid AS risk.Results: The levels of single item and CIMT in the hypertension combined with cerebral infarction group were higher, and the values of R, EPL, and LY30 were lower than corresponding indicators in the simple hypertension group. Furthermore, it was found that Lp-PLA2 and Hcy were risk factors. The AUC for Hcy and Lp-PLA2 for the determination the carotid AS risk were larger. Conclusions: The increase or decrease of Lp-PLA2, Hcy, and TEG were important factors influencing the development of carotid AS with combined hypertension and cerebral infarction. The levels of Lp-PLA2, Hcy, and TEG with combined hypertension and cerebral infarction were significantly different from those with simple hypertension and could be used as independent predictive factors for determining carotid AS risk.
Adenovirus Virus Expressing Myostatin- Somatostatin Fusing Gene Promote the Growth Rate of the Mice
Authors: Wang Xinglong , Xu Gaoxiao , Zhang Ning , Chen Xingfa , Yu Dongling 
Published: December 2019

Abstract
Myostatin (MSTN) and somatostatin (SST) are negative regulate factors in the animals. Immunized animals with these proteins induce the related immune response, which could neutralize the normal inhibitory effects of these proteins. Since adenovirus was the mostly wildly used vector for delivering vaccine antigen, here, a recombinant adenovirus expressing MSTN-SST were constructed and mice were inoculated with the recombinant adenovirus. As our predicted, immunization with this adenovirus one time or two times were all induced the specific immune response and resulting in an improve growth rate and muscle mass. And boost immunization improved the effect of the immunization. Accordingly, adenovirus can be used as a vector for deliver myostatin and somatostatin gene, so as to increase animal growth rate and muscle mass of the animals.
Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people (66 year-olds) in South Korea
Authors: Lee Yeong Chan , Kang Jae Myeong , Lee Hyewon , Kim Kiwon , Kim Soyeon , Yu Tae Yang , Lee Eun-Mi , Kim Clara Tammy , Kim Doh Kwan , Lewis Matthew , Won Hong-Hee , Jessen Frank , Myung Woojae 
Published: December 2019

Abstract
Background: Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea.Methods: This cohort included 579,710 66-year-old adults who completed a questionnaire about SCD and were followed-up for a total of 3,870,293 person-years (average 6.68 years per person). Hazard ratios were estimated using the Cox proportional hazards model and compared between subjects with and without SCD.Results: Compared to subjects without SCD, those with SCD were more likely to develop dementia (incidence per 100,000 person-years: no SCD: 566.14; SCD: 859.35). After adjusting for potential confounding factors, the risk of subsequent dementia significantly increased in subjects with SCD, with an adjusted hazard ratio (aHR) of 1.38 (95% confidence interval [CI] 1.34 to 1.41). The risk of subsequent dementia was greatly increased in subjects with higher SCD scores (aHR=2.77, 95% CI 2.47 to 3.11). A significant association between SCD and dementia was observed in both depressive and non-depressive symptom groups (aHR=1.50, 95% CI 1.42 to 1.57 in subjects with depressive symptoms; aHR=1.33, 95% CI 1.29 to 1.37 in subjects without depressive symptoms; P =0.001).Conclusions: In the participating 66-year-old population, SCD was significantly associated with an increased risk of subsequent dementia, independent of the presence of depressive symptoms. Our findings suggest that SCD indicates a risk for dementia. Further studies are needed to delineate potential approaches to preventing the development of dementia in individuals with SCD.
Los pueblos indígenas en México y sus derechos humanos
Authors: Valdez Valenzuela Francisco Javier , Valdez Domínguez Manuel Raymundo , Coronado Gutiérrez Álvaro 
Published: December 2019

El presente trabajo está enfocado en definir lo que en México se entiende por comunidad o pueblo indígena, bajo la perspectiva que la Constitución Federal otorga; al mismo tiempo, abordaremos cuáles son los derechos fundamentales de los pueblos indígenas, tratando de dar una breve explicación de estos. Seguidamente, se establece el tratamiento que se le ha dado en la actualidad a los derechos humanos de los pueblos indígenas en México, derivado de la adhesión al convenio 169 de la Organización Internacional del Trabajo y, como consecuencia de ello, la creación de un marco jurídico regulatorio que, a través de leyes secundarias, se ha ocupado en atender y promover el respeto a los derechos fundamentales de los pueblos indígenas. La segunda parte del trabajo se enfoca en identificar algunos de los derechos fundamentales que han sido vulnerados a los pueblos indígenas en México, ello a pesar de la existencia de una legislación constitucional y secundaria, en el ámbito federal y local, específicamente en lo relativo a la vulneración de los territorios indígenas y la falta de consulta a los mismos por parte del Estado. Por último, y no obstante la promoción oficial, educativa y social de los derechos humanos con respecto a las comunidades indígenas, lamentablemente hacia su interior, son las mismas estructuras de poder de dichos grupos, quienes violentan los derechos humanos de las personas, en especial de las mujeres, quienes juegan un roll mísero al interior de las sociedades primarias, contradiciéndose con la lucha por el respeto a sus derechos humanos desde el exterior.
Analisis Kestabilan Model Matematika pada Pertumbuhan Kanker denga Pengobatan Menggunakan Virus Oncolytic
Authors: Faizah Nur , Cahyono Budi , Fitriyah Aini 
Published: December 2019

<p>Pada artikel ini dibahas analisis kestabilan model matematika pada pertumbuhan kanker yang pengobatannya menggunakan Virus <em>Oncolytic. </em>Model matematika pada penelitian ini diasumsikan bahwa sel kanker yang terdapat pada tubuh penderita terdiri dari sel kanker yang tidak terinfeksi Virus <em>Oncolytic (</em><em>) </em>dan sel kanker yang terinfeksi Virus <em>Onvolytic </em>. Oleh karena itu, sel kanker yang dimodelkan merupakan sistem persamaan differensial nonlinear orde satu dengan dua variabel. Adapun analisis yang dilakukan pada penelitian ini dilakukan secara analitik dan numerik. Analisis secara analitik meliputi langkah-langkah seperti penentuan titik kesetimbangan, analisis kestabilan lokal dan analisis kestabilan global sedangkan analisis secara numerik dilakukan dengan bantuan aplikasi MATLAB. Dari hasil penelitian diperoleh empat titik kesetimbangan dengan kondisi kestabilan setiap titik-titiknya bersyarat. Artinya kestabilan titik kesetimbangan tersebut berlaku jika syarat tersebut dipenuhi. Salah satu kestabilan yang diperoleh adalah Titik Ekuilibrium stabil lokal jika dan hanya jika dan . Setelah dilakukan analisis secara analitik dilanjutkan dengan mencari simulasi numerik untuk mengilustrasikan dan menguji hasil analitiknya. Adapun hasil numerik yang diperoleh adalah grafik-grafik menunjukkan bahwa solusi dari sitem tersebut stabil. Hal itu menunjukkan bahwasanya pengobatan kanker dengan menggunakan Virus <em>Oncolytic </em>memperoleh hasil yang baik.</p>
Uric Acid in Metabolic and Cerebrovascular Disorders: A Review
Authors: Cortese Francesca , Scicchitano Pietro , Cortese Anna M. , Meliota Giovanni , Andriani Andrea , Truncellito Luigi , Calculli Giacinto , Giordano Paola , Ciccone Marco M. 
Published: December 2019

Background:Several studies showed a close link between metabolic syndrome (MetS), type 2 diabetes (T2DM) and cerebrovascular diseases. There is considerable debate regarding the role of uric acid (UA) as a risk factor in these conditions.Objective:The aim of this narrative review is to discuss the links between UA, MetS, T2DM and cerebrovascular disease.Methods:An extensive review has been conducted based on the scientific literature published in English, and indexed in MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and Google Scholar from January to May 2019. Additional relevant studies published after the initial review were also considered during the period of June 2019-October 2019, during which, this manuscript was written. The Mesh Terms considered were: uric acid, antioxidant, oxidant, metabolic syndrome, diabetes, cerebrovascular diseases, stroke, haemorrhagic stroke, neurocognitive disorders, and their combinations.Results:The literature review shows a dose-dependent inflammatory action of UA, which occurs with serum concentrations >4 mg/dl (>0.24 mmol/l), representing one of the contributors to the chronic inflammatory process that underlies metabolic and cerebrovascular diseases.Conclusion:UA, which is associated with arterial hypertension and cardiovascular diseases, represents one of the indicators of oxidative homeostasis. Increasing concentrations represent a status of active inflammation which is observed with metabolic and cerebrovascular diseases.
Development and Field Evaluation of the INTER-ACT App, a Pregnancy and Interpregnancy Coaching App to Reduce Maternal Overweight and Obesity: Mixed Methods Design
Authors: Bogaerts Annick , Bijlholt Margriet , Mertens Lotte , Braeken Marijke , Jacobs Bart , Vandenberghe Bert , Ameye Lieveke , Devlieger Roland 
Published: December 2019

Background
The interpregnancy and pregnancy periods are important windows of opportunity to prevent excessive gestational weight retention. Despite an overwhelming number of existing health apps, validated apps to support a healthy lifestyle between and during pregnancies are lacking.

Objective
To describe the development and evaluation of the INTER-ACT app, which is part of an interpregnancy and pregnancy lifestyle coaching module, to prevent excessive weight gain in pregnancy and enhance optimal weight and a healthy lifestyle in the interpregnancy period.

Methods
A mixed methods design was used to identify the needs of health care providers and end users, according to 15 semistructured interviews, two focus groups, and two surveys. The user interface was evaluated in a pilot study (N=9).

Results
Health care providers indicated that a mobile app can enhance a healthy lifestyle in pregnant and postpartum women. Pregnant women preferred graphic displays in the app, weekly notifications, and support messages according to their own goals. Both mothers and health care providers reported increased awareness and valued the combination of the app with face-to-face coaching.

Conclusions
The INTER-ACT app was valued by its end users because it was offered in combination with face-to-face contact with a caregiver.
Importance of Nanocarriers and Probiotics in the Treatment of Ulcerative Colitis
Authors: Singh Amandeep , Kaur Kirandeep , Kaur Veerpal , Singh Gurmeet , Mandal Uttam Kumar , Mishra Neeraj , Narnag Raj Kumar 
Published: December 2019

Ulcerative colitis (UC) is an inflammatory chronic disease primarily affecting the colonic mucosa; the extent and severity of colon involvement are variable. In its most limited form, it may be restricted to the distal rectum, while in its most extended form the entire colon is involved. Ulcerative colitis is identified by mucus diarrhea, tenesmus, bowel distension, and anemia. 5-aminosalicylic acid drugs, steroids, and immunosuppressant are used for therapy of ulcerative colitis. The annual occurrence of disease in Asia, America, and Europe was estimated to be 6.3, 19.2 and 24.3 per 100,000 people-years. The main challenges in the management of the diseaseare drug-related side-effects and local targeting. To overcome these challenges probiotics and micro and Nano particulate system auspicious approaches to overcome drug-related adverse side effect and local targeting. Upon ingestion, the probiotics can result in health beneficial effects. Probiotics are mainly used as gut modulators but are also now days explored for their use in ulcerative colitis. Micro and Nano particulate drug delivery system have been achieving huge importance for targeting of the drug to colon locally at a controlled and sustained rate. The main objective of this article is to explore probiotics and micro and nano particulate approaches for the suitable targeting and overcome the drug-associated side effect.
Keywords: Inflammatory chronic disease, probiotics, micro and Nano particulate.
Prevalence and Pattern of Adverse Drug Reactions among HIV Infected Patients on Highly Active Antiretroviral Therapy (HAART) in Imo State, Nigeria: A Hospital Based Survey
Authors: Chioma A. Duru , Chukwuma B. Duru , Chinomnso C. Nnebue 
Published: December 2019

Introduction: It is a proven fact that almost all drugs carry the potential to produce undesirable effects in addition to the desired ones.
Aim: The aim of this study is to determine the prevalence, pattern and socio-demographic determinants of adverse drug reactions among patients on HAART attending clinics in hospitals in Imo State Nigeria.
Methodology: This was a hospital-based cross-sectional study carried out among HIV patients attending clinics in hospitals in Imo State. The 400 participants were selected using a multistage sampling technique. Data was collected using an interviewer administered, semi-structured questionnaire and analyzed using EPI Info version 3:2:1. Chi-square and regression analysis was used to test association between variables. P-value was set at ≤ 0.05.
Results: The mean age of the participants was 41.7±3.0 years with a male to female ration of 1:2. The adherence level to HIV treatment was 85.0%. The prevalence of ADRs in the last 1 year preceding the study was 13.7% and the common forms of ADR experienced by patients was Hematological symptoms (34%), GIT symptoms (21.8%) and skin manifestation (20.0%). Socio-demographic determinants of the occurrence of ADR among the participants were: age 50 years and above (OR: 9.28), female gender (OR: 2.55) and living in a rural area (OR: 4.47).
Conclusion: Though the prevalence of ADR reported in this study was low, there is need to increase the depth of knowledge among HIV patients in the State, monitor patients closely by care givers and find possible ways to increase adherence to HIV drugs which was not optimal among participants.
Keywords: Prevalence, Pattern, Adverse Drug reactions, HAART, HIV, Patients, Imo State.
A szerző halott, az olvasó megszületett
Authors: Harvay Anna 
Published: December 2019

Recenzió David Harris: Society of signs (London, Routledge 1996, 256
pages, ISBN 9780415111294) c. művéről.
---
The author is dead, the reader is born
Book review on David Harris: Society of signs (London, Routledge 1996, 256 pages, ISBN 9780415111294).
Penerapan Model Pmbelajaran Think Pair Share Untuk Meningkatkan Motivasi Belajar Sosiologi Siswa Kelas XI IPS SMA N 2 Batang Anai
Authors: Delviani Indah , Junaidi Junaidi 
Published: December 2019

Penelitian ini dilatarbelakangi oleh rendahnya motivasi belajar siswa di SMA Negeri 2 Batang Anai khususnya pada kelas XI IPS 2. Berdasarkan hal tersebut upaya yang cocok untuk meningkatkan motivasi belajar siswa dengan adanya rancangan pembelajaran yang tepat, yaitu dengan menggunakan model Think Pair Share. Tujuan penelitian ini adalah mendiskripsikan penerapan model pembelajaran Think Pair Share dalam meningkatkan motivasi belajar kelas XI IPS SMA Negeri 2 Batang Anai. Penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan dengan dua siklus. Siklus pertama dilakukan dua kali pertemuan dan siklus kedua dilakukan dua kali pertemuan. Setiap siklus terdiri dari 4 tahap kegiatan yaitu perencanaan, tindakan, pengamatan dan refleksi. Subjek penelitian adalah siswa kelas XI IPS 2 SMA Negeri 2 Batang Anai yang berjumlah 32 orang. Pada penelitian ini peneliti menetapkan batasan keberhasilan pemahaman kosep siswa pada kategori baik level tengah yaitu 70%. Hasil penelitian menunjukkan bahwa Penerapan Model Pembelajaran Think Pair Share dapat meningkatkan Motivasi Belajar Sosiologi siswa kelas XI IPS 2 SMA Negeri 2 Batang Anai tahun ajaran 2019/2020 yang dibuktikan dengan adanya peningkatan persentase skor Observasi Motivasi Belajar sosiologi dilakukan tindakan pada siklus I skor rata-rata mengalami peningkatan sebesar 12,3% menjadi 41,98%. Peningkatan juga terjadi pada siklus I ke siklus II yaitu sebesar 34,64 % menjadi 76,62 % pada siklus II.
Holistic view on corporate bankruptcy causes: systematization of causes and requirements to building bankruptcy prediction models
Authors: Kliestik Tomas 
Published: December 2019

The article presents the research of bbusinesses’ life cycle as complex organisms that do not exist in isolation, but in mutual interaction with other subjects operating in the national economy, other businesses, non-financial or financial corporations, government agencies or customers and households. The essence of the crisis as the motive force of any market economy is revealed. The causes of bankruptcy of enterprises are considered. It has been stated that bankruptcy of the enterprise can result in a chain reaction with negative consequences for all economic entities. Every economy in the world (not only market economy) is confronted with failures or bankruptcy of business entities. There exist a variety of forms, manifestations and consequences of business failures. There has been substantiated the importance of the research, the essentiality of a detailed analysis of methods of bankruptcy prediction models, i.e. determining probable development of the corporate principles in the coming years. In the centrally planned economies, the state is responsible for all the consequences; in the market economy they directly affect all entities interrelated with the enterprise. Each group involved applies a wide range of tools, algorithms and methods, but their aim is identical: to predict the future development of the corporate financial health. There appear questions about termination of activity of a particular enterprise due to its future bankruptcy, shutting down because of bad decisions, or the impact of endogenous and exogenous factors. Development of the algorithms and methods is not possible without a detailed, almost holistic knowledge
of the causes of corporate bankruptcies. A methodological toolkit based on numerous studies
of specialists has been developed for building bankruptcy models.
Technologies of digital economy as tools for improving quality of life, business efficiency and public administration
Authors: Shendo Maria Vladimirovna , Sviridova Elena Viktorovna 
Published: December 2019

The world gets quickly covered by networks that enable connectivity and data transfer between digital devices. More than 40% of the world's population has access to the Internet. As digital networks spread around the world and the economic benefits of digitalization increase, we are witnessing a digital transformation. The application of digital technologies supports innovations in business and industry, improves the life standards of citizens and efficiency of public administra-tion. Russia has certain prospects in the development of the national digital economy for develop-ing the information infrastructure, finalizing the regulatory framework and providing this process with the appropriate personnel. The role of IT-technologies in the economy of the Russian Federa-tion is indicated, the rating of the digital economies of the world is presented, in which Russia takes 39th place. There have been considered the basic concepts of the digital economy, defined and classified areas of application of its technologies, identified categories of their application with ex-amples of existing projects of the digital economy. A statistical analysis of the prospects of the Russian digital economy has been conducted; the categories of new jobs in the changing labor market are singled out in the framework of digitalization, as well as of the scope of their application.
A particular attention is paid to analysis of the Internet of things technology, which has an impact on the surrounding world, including the labor market. Specialties in the IT industry include various disciplines: computer science, computer engineering, and software development. Vacancies in the changing digital world are conditionally classified: “implementers”, “developers”, “improvers”. Conclusions are drawn as a result of the expansion and widespread introduction of digital technol-ogies on the prospects for the development of the economies of each individual state, the estab-lishment of cooperation between countries and solving of many global problems.
Spatio-temporal variation of scarab beetles (Coleoptera: Scarabaeidae) in two oak biotopes of Ouled Bechih Forest, Souk-Ahras region (north-eastern Algeria)
Authors: Ganaoui Nawel , Maazi Mohamed Chérif , Chefrour Azzedine 
Published: December 2019

Abstract
This paper presents the results of a comparative study with the objective of studying the spatio-temporal variation in the abundance and richness of scarab beetles in two oak biotopes (cork oak – Quercus suber and zeen oak – Q. canariensis) of the Ouled Bechih Forest in the Souk-Ahras region of north-eastern Algeria during 2017. Two sampling techniques were used: pitfall traps and bidirectional glass traps. During the study period 6022 individuals were collected and 17 species of the family Scarabaeidae were identified. The results of nonparametric tests (Mann-Whitney U-test and Kruskal-Wallis H-test) show that there is a significant difference in abundance and richness between the two biotopes and from March to August. These two biodiversity parameters were greater in the cork oak than in the zeen oak forests. The activity of the scarab beetles was much higher in the dry season, but lower in the rainy season. The phytophagous species were most influenced by seasonality, especially in the cork oak biotopes, whereas the coprophagous ones remained relatively constant in both habitats.
Gedanoleria eocenica – a new genus and species from Eocene Baltic amber (Diptera: Heleomyzidae), with notes on heleomyzid-like flies from African copal
Authors: Woźnica Andrzej Józef 
Published: December 2019

Abstract
A new genus and species of a handsome heleomyzid fly, Gedanoleria eocenica gen. nov., sp. nov. (Diptera: Heleomyzidae), is described from Baltic amber. The newly described genus is compared with similar extant and extinct genera. The heleomyzid-like flies described by Meunier from African copal are treated as nomina dubia. A checklist and a key to the genera of Heleomyzidae reported from fossil resins are also provided.