bluuebunny/crossref_metadata_2025_split huggingface dataset:
O que são estudos de gênero: caracterização da produção científica autodenominada estudos de gênero em uma base de dados multidisciplinar e internacional
Authors: Hoppen Natascha Helena Franz , Vanz Samile Andrea de Souza 
Published: July 2020

Objetivo: Caracterizar qual é a pesquisa que se intitula como “estudos de gênero” em uma base de dados multidisciplinar e internacional, apontando também as possibilidades e as limitações no uso desse tipo de base de dados.Método: A pesquisa apresenta um estudo exploratório com análise bibliométrica da produção científica autodenominada estudos de gênero, indexada na Web of Science e publicada até o ano de 2017.Resultados: Os resultados refletem a história da área, com documentos identificados na base desde 1981 e crescendo até os últimos anos. Aponta a diversidade de disciplinas que pesquisam estudos de gênero, especialmente as ligadas às ciências humanas e sociais, mas também áreas como ciências da saúde e medicina. O número de publicações aumentou desde os anos 90, bem como a interdisciplinaridade, visto que houve aumento de disciplinas passando a publicar sobre (ou com abordagem de) estudos de gênero. A análise comparando diferentes períodos demonstra o seguinte: um aumento de publicações em coautoria; diferentes disciplinas e áreas do conhecimento ingressando nos estudos de gênero; periódicos mais gerais e multidisciplinares publicando estudos da área e também aumento de periódicos especializados em estudos de gênero. Também identifica impacto importante de trabalhos de evento e dispersão de veículos de publicação. Os EUA e países europeus são os mais produtivos, no entanto, Brasil, Argentina e Austrália se destacam por possuir algumas das instituições e fontes de publicação mais produtivas. A análise de termos aponta para pesquisas relacionadas à educação e ensino, assim como a importância de tópicos de influência pós-estruturalista. Pesquisas relacionadas à masculinidade e à sexualidade parecem ser emergentes na área, no entanto, os artigos sobre sexualidade são mais raros, enquanto palavras como masculino e masculinidade aparecem nos termos mais frequentes e nas publicações com mais citações. Os assuntos e termos das publicações também sugerem que os estudos de gênero, como seria de esperar, estão acompanhando as temáticas dos movimentos feministas.Conclusões: A produção científica de estudos de gênero indexada na Web of Science demonstra a consolidação da área ao longo dos anos e seu reconhecimento entre os campos do conhecimento científico à medida que diferentes disciplinas passaram a publicar na área. Apesar de muitas características interessantes e pertinentes terem sido levantadas, a cobertura da base de dados para esse tipo de pesquisa é limitada. A qualidade dos dados também é uma limitação, visto que campos dos registros de dados estavam ausentes, especialmente ema documentos das ciências humanas e sociais. Por fim, sugerimos o uso de termos adicionais em pesquisas futuras.
Variability and Genetic Diversity of Bottle Gourd [Lagenaria siceraria (mol.) Stand.] in Bangladesh
Authors: Quamruzzaman A. K. M. , Islam F. , Salim M. M. R. , Akhter L. , Rahman M. M. , Chowdhury M. A. Z. 
Published: July 2020

The presented study was conducted at the experimental field of Olericulture Division, Horticulture Research Center, Bangladesh Agricultural Research Institute, Gazipur, Bangladesh during the year 2018-19 to assess the extent of genetic diversity among 25 bottle gourd germplasms. Data on: days to first harvest, fruit number per plant, average fruit weight, fruit yield (kg/plant), fruit length, fruit diameter, fruit yield (t/ha), fruit shape and fruit color were recorded. Plot means for quantitative characters were used for the statistical analysis, while genetic diversity, principal component analysis (PCA), principal Coordinate analysis (PCO), cluster analysis, cluster means and two-dimensional scattered plotting diagram were studied. The germplasms were constellated into five distinct groups with the range of 3 germplasms in the cluster III to 6 germplasms in the clusters II and IV. The inter-cluster distance in all cases was larger than is the intra-cluster distance. The highest intra-cluster value (2.65) was found in the cluster IV. Maximal inter-cluster distance (12.24) was observed between germplasm of cluster I and V, followed by the clusters I and III (12.05) and minimal was found between germplasms of cluster I and IV (3.46). In case of the cluster means values and yield contributing performance cluster I, cluster IV and cluster III performed well. Considering the group distance and inter-genotypic crosses between the clusters and cluster means, inbreeds belong to clusters: I, IV and III, to that will be given higher priority for crossing in future bottle gourd hybridization program.
Universality vs experience: a cross-cultural pilot study on the consonance effect in music at different altitudes
Authors: Prete Giulia , Bondi Danilo , Verratti Vittore , Aloisi Anna Maria , Rai Prabin , Tommasi Luca 
Published: July 2020

Background
Previous studies have shown that music preferences are influenced by cultural “rules”, and some others have suggested a universal preference for some features over others.

Methods
We investigated cultural differences on the “consonance effect”, consisting in higher pleasantness judgments for consonant compared to dissonant chords—according to the Western definition of music: Italian and Himalayan participants were asked to express pleasantness judgments for consonant and dissonant chords. An Italian and a Nepalese sample were tested both at 1,450 m and at 4,750 m of altitude, with the further aim to evaluate the effect of hypoxia on this task. A third sample consisted of two subgroups of Sherpas: lowlanders (1,450 m of altitude), often exposed to Western music, and highlanders (3,427 m of altitude), less exposed to Western music. All Sherpas were tested where they lived.

Results
Independently from the altitude, results confirmed the consonance effect in the Italian sample, and the absence of such effect in the Nepalese sample. Lowlander Sherpas revealed the consonance effect, but highlander Sherpas did not show this effect.

Conclusions
Results of this pilot study show that neither hypoxia (altitude), nor demographic features (age, schooling, or playing music), nor ethnicity per se influence the consonance effect. We conclude that music preferences are attributable to music exposure.
The BCL‐2 family protein inhibitor ABT‐737 as an additional tool for the treatment of EBV‐associated post‐transplant lymphoproliferative disorders
Authors: Robert Aude , Pujals Anaïs , Favre Loetitia , Debernardi Justine , Wiels Joëlle 
Published: July 2020

Post‐transplant lymphoproliferative disorders (PTLD) and Burkitt's lymphoma (BL) are B‐cell malignancies strongly associated with Epstein–Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression of the anti‐apoptotic protein BCL‐2. Given its chemoprotective effect, BCL‐2 constitutes an attractive target for new therapeutic strategies for EBV‐positive B‐cell malignancies. Here, we show that ABT‐737, a small inhibitor of BCL‐2, BCL‐X(L), and BCL‐w, strongly induced apoptosis in vitro in EBV‐positive lymphoblastoid cell lines (which is a model for PTLD), whereas BL was less sensitive. ABT‐737 reduced tumor growth and increased the overall survival of mice in a xenograft model of PTLD but had no effect on BL xenograft mice. ABT‐737 combined with a low dose of cyclophosphamide, a major component of the conventional CHOP chemotherapy regimen for BL patients, reduced tumor growth during treatment but failed to improve the overall survival of BL xenograft mice. By contrast, the combination of ABT‐737 and rituximab, one of the main options for the treatment of PTLD, was highly efficient and induced approximately 70% remission in PTLD xenograft mice. These results suggest that the use of agents targeting BCL‐2, either alone or in combination with other conventional drugs, represents a novel promising approach for post‐transplant EBV‐positive B lymphoproliferative disorders.
Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer’s disease
Authors: Pillai Jagan A. , Bena James , Bebek Gurkan , Bekris Lynn M. , Bonner‐Jackson Aaron , Kou Lei , Pai Akshay , Sørensen Lauge , Neilsen Mads , Rao Stephen M. , Chance Mark , Lamb Bruce T. , Leverenz James B. ,   the Alzheimer’s Disease Neuroimaging Initiative
Published: July 2020

AbstractObjectiveTo determine the inflammatory analytes that predict clinical progression and evaluate their performance against biomarkers of neurodegeneration.MethodsA longitudinal study of MCI‐AD patients in a Discovery cohort over 15 months, with replication in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort over 36 months. Fifty‐three inflammatory analytes were measured in the CSF and plasma with a RBM multiplex analyte platform. Inflammatory analytes that predict clinical progression on Clinical Dementia Rating Scale‐Sum of Boxes (CDR‐SB) and Mini Mental State Exam scores were assessed in multivariate regression models. To provide context, key analyte results in ADNI were compared against biomarkers of neurodegeneration, hippocampal volume, and CSF neurofilament light (NfL), in receiver operating characteristic (ROC) analyses evaluating highest quartile of CDR‐SB change over two years (≥3 points).ResultsCerebrospinal fluid inflammatory analytes in relation to cognitive decline were best described by gene ontology terms, natural killer cell chemotaxis, and endothelial cell apoptotic process and in plasma, extracellular matrix organization, blood coagulation, and fibrin clot formation described the analytes. CSF CCL2 was most robust in predicting rate of cognitive change and analytes that correlated to CCL2 suggest IL‐10 pathway dysregulation. The ROC curves for ≥3 points change in CDR‐SB over 2 years when comparing baseline hippocampal volume, CSF NfL, and CCL2 were not significantly different.InterpretationBaseline levels of immune cell chemotactic cytokine CCL2 in the CSF and IL‐10 pathway dysregulation impact longitudinal cognitive and functional decline in MCI‐AD. CCL2’s utility appears comparable to biomarkers of neurodegeneration in predicting rapid decline.
Organic N‐Type Molecule: Managing the Electronic States of Bulk Perovskite for High‐Performance Photovoltaics
Authors: Chen Haiyang , Zhan Yu , Xu Guiying , Chen Weijie , Wang Shuhui , Zhang Moyao , Li Yaowen , Li Yongfang 
Published: July 2020

AbstractThe power conversion efficiency (PCE) of planar p–i–n perovskite solar cells (pero‐SCs) is commonly lower than that of the n–i–p pero‐SCs, due to the severe nonradiative recombination stemming from the more p‐type perovskite with prevailing electron traps. Here, two n‐type organic molecules, DMBI‐2‐Th and DMBI‐2‐Th‐I, with hydrogen‐transfer properties for the doping of bulk perovskite aimed at regulating its electronic states are synthesized. The generated radicals in these n‐type dopants with high‐lying singly occupied molecular orbitals enable easy transfer of the thermally activated electrons to the MAPbI3 perovskite for the realization of n‐doped perovskites. The n‐doping degree could be further enhanced by using the iodine ionized dopant DMBI‐2‐Th‐I. The doping effect could reduce the electron trap density, increase the electron concentration of the bulk perovskite, and simultaneously improve the surface electronic contact. When the DMBI‐2‐Th‐I‐doped perovskite is used in planar p–i–n pero‐SCs, the nonradiative recombination is significantly suppressed. As a result, the photovoltaic performance improved significantly, as evidenced by an excellent PCE of 20.90% and a robust ambient stability even under high relative humidity. To the best of the knowledge, this work represents the first example where organic n‐type dopants are used to tune the electronic states of a bulk perovskite film for efficient planar p–i–n pero‐SCs.
RNAi Screening Identifies that TEX10 Promotes the Proliferation of Colorectal Cancer Cells by Increasing NF‐κB Activation
Authors: Wang Ziyang , Sheng Chunjie , Kan Guangyan , Yao Chen , Geng Rong , Chen Shuai 
Published: July 2020

AbstractColorectal cancer (CRC) has become a predominant cancer worldwide. To understand the process of carcinogenesis, a short hairpin RNA library screening is employed to search for candidate genes that promote proliferation in the CRC cell line HT29. The candidate genes overlap with differentially expressed genes in 32 CRC tumor tissues in the GEO dataset GSE8671. The seventh‐ranked testis expressed 10 (TEX10) is upregulated in CRC and its knockdown decreases cell proliferation. The TEX10 high‐expression group exhibits worse overall survival (P = 0.003) and progression‐free survival (P = 0.001) than the TEX10 low‐expression group. TEX10 depletion decreases the growth of CRC cells in vitro and in vivo. Gene set enrichment analysis indicates that the nuclear factor‐kappa B pathway is significantly enriched in the genes downregulated by TEX10 knockdown. Mechanistically, TEX10 interacts with RELA and increases its nuclear localization. TEX10 promotes RELA occupancy at gene promoters and regulates the expression of a subset of RELA‐targeted genes, including TNFAIP8, SAT1, and IL6ST. Taken together, this study identifies that TEX10 promotes the proliferation of CRC cells in an RELA‐dependent manner. In addition, high TEX10 expression is associated with poor prognosis in CRC patients.
12q21 deletion syndrome: Narrowing the critical region down to 1.6 Mb including SYT1 and PPP1R12A
Authors: Niclass Tanguy , Le Guyader Gwenael , Beneteau Claire , Joubert Madeleine , Pizzuti Antonio , Giuffrida Maria Grazia , Bernardini Laura , Gilbert‐Dussardier Brigitte , Bilan Frederic , Egloff Matthieu 
Published: July 2020

AbstractDeletions in the 12q21 region are rare and non‐recurrent CNVs. To date, only 11 patients with deletions in this region have been reported in the literature. These patients most often presented with syndromic intellectual deficiency, ventriculomegaly or hydrocephalus, ectodermal abnormalities, growth retardation and renal and cardiac malformations, suggesting a recognizable microdeletion syndrome. We report three new patients with overlapping deletions of the 12q21 region, including the smallest deletion reported to date and the first case characterized by array CGH during pregnancy. We describe specific clinical findings and shared facial features as developmental delay, ectodermal abnormalities, ventriculomegaly or hydrocephalus, axial hypotonia or spastic diplegia, growth retardation, heart defect, hydronephrosis, ureteral reflux or horseshoe kidney, large thorax or pectus excavatum, syndactyly of 2–3 toes, pterygium coli or excess nuchal skin, large anterior fontanel, low set ears, prominent forehead, short‐upturned nose with nostril hypoplasia, microretrognathia and hypertelorism. These new patients and a comprehensive review of the literature allow us to define a minimum critical region spanning 1.6 Mb in 12q21. By screening the critical region using prediction tools, we identified two candidate genes: SYT1and PPP1R12A.
Immunotherapy in sinonasal melanoma: treatment patterns and outcomes compared to cutaneous melanoma
Authors: Klebaner Daniella , Saddawi‐Konefka Robert , Finegersh Andrey , Yan Carol H. , Califano Joseph A. , London Nyall R. , Deconde Adam S. , Faraji Farhoud 
Published: July 2020

BackgroundAlthough treatment with checkpoint blockade is now accepted as standard of care for cutaneous melanoma, few studies have investigated its role in sinonasal melanoma (SNM). We aimed to evaluate whether immunotherapy was associated with improved survival in SNM and to compare the effect of immunotherapy in metastatic sinonasal and cutaneous melanoma.MethodsThis was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with sinonasal or cutaneous melanoma between 2012 and 2015 and had complete information regarding immunotherapy status. The primary outcome was overall survival. The influence of immunotherapy on overall survival was compared by Kaplan‐Meier and Cox proportional hazards models. Propensity score matched analyses between SNM patients who received immunotherapy and those who did not were based on clinicopathological covariates associated with survival in univariate Cox models.ResultsThe analytic cohort consisted of 704 patients with SNM, 94 of whom were treated with immunotherapy and 152,896 patients with cutaneous melanoma, 8055 of whom were treated with immunotherapy. Immunotherapy was not associated with survival in the propensity‐score matched cohort (n = 195; hazard ratio [HR] = 1.0; 95% confidence interval [CI], 0.7 to 1.5; p = 0.88) or in adjusted Cox proportional hazards model (n = 549; HR = 1.0; 95% CI, 0.74 to 1.4; p = 0.88). Regimens including immunotherapy were associated with improved overall survival in metastatic cutaneous melanoma (HR = 0.57; 95% CI, 0.49 to 0.66; p < 0.0001), but not metastatic SNM (HR = 1.1; 95% CI, 0.67 to 1.7; p = 0.75).ConclusionCompared to current standard of care therapy, inclusion of immunotherapy as first‐line therapy was not associated with improved survival in SNM.
Comparing reusable to disposable products: Life cycle analysis metrics
Authors: Alshqaqeeq Fadhel , Griffing Evan , Twomey Janet , Overcash Michael 
Published: July 2020

AbstractThis research is to produce the first quantitative evaluation, using global warming potential (GWP, kg CO2 eq), of all published cradle‐to‐gate life cycle studies that compare reusable vs single‐use products. We seek to determine whether there are consistent and fundamental factors that differentiate disposable and reusable products. A comparative assessment was made of the cradle‐to‐gate life cycle analyses of all published comparisons of reusable and single‐use products from 1990 to 2016. A literature search found only 20 products in which a full life cycle analysis of cradle‐to‐gate (supply chain, manufacturing, reprocessing, and packaging of the reusable item) and supply chain plus manufacturing for the disposable had been published. GWP or carbon footprint was used as the environment comparison metric to which we added energy for the product manufacturing metrics. In this diverse set of products, the reusable product was consistently lower in cradle‐to‐gate energy use and global warming potential than the comparable single‐use product. However, no apparent product characteristic appeared to govern the extent by which the reusable had a lower carbon footprint. These compelling results were compared with two other references in which disposable products were reported as better. However, when the data were reviewed with those authors, they reevaluated and found errors in calculations and corrected the results to then identify the lower reusable GWP impact compared to the respective disposable. The diversity of products studied and the consistently lower GWP impact of reusable products herein may suggest that products with reusable/disposable options could be predicted to show that the reusable is better than the single‐use option.
Synthetic Macrocycle‐Based Nonporous Adaptive Crystals for Molecular Separation
Authors: Wu Jia‐Rui , Yang Ying‐Wei 
Published: July 2020

AbstractThe exploitation of new materials for adsorptive separation of industrially important hydrocarbons is of great importance in both scientific research and petrochemical industry. Nonporous adaptive crystals (NACs) as a robust class of synthetic materials have drawn much attention during the past five years for their superior performance in adsorption and separation. Pillararenes are the main family of macrocyclic arenes used for NACs construction, where the structure–function relationship has been intensively studied. In the past two years, some emerging types of synthetic macrocyclic arenes have been successfully brought into this research field, showing the gradual enrichment and diversification of NACs materials. This Minireview summarizes the recent advances of synthetic macrocycle‐based NACs, which are categorized by various practical applications in molecular separation. Besides, NACs‐based vapochromic supramolecular systems are also discussed. Finally, future perspectives and challenges of NACs are given. We envisage that this Minireview will be a useful and timely reference for those who are interested in new molecular and supramolecular crystals for storage and separation applications.
Stretchable Electrochemical Sensors for Cell and Tissue Detection
Authors: Liu Yan‐Ling , Huang Wei‐Hua 
Published: July 2020

AbstractElectrochemical sensing based on conventional rigid electrodes has great restrictions for characterizing biomolecules in deformed cells or soft tissues. The recent emergence of stretchable sensors allows electrodes to conformally contact to curved surfaces and perfectly comply with the deformation of living cells and tissues. This provides a powerful strategy to monitor biomolecules from mechanically deformed cells, tissues, and organisms in real time, and opens up new opportunities to explore the mechanotransduction process. In this minireview, we first summarize the fabrication of stretchable electrodes with emphasis on the nanomaterial‐enabled strategies. We then describe representative applications of stretchable sensors in the real‐time monitoring of mechanically sensitive cells and tissues. Finally, we present the future possibilities and challenges of stretchable electrochemical sensing in cell, tissue, and in vivo detection.
C−H Activation Based Copper‐Catalyzed One‐Shot Synthesis of N,O‐Bidentate Organic Difluoroboron Complexes
Authors: Tan Guangying , Schrader Malte L. , Daniliuc Constantin , Strieth‐Kalthoff Felix , Glorius Frank 
Published: July 2020

AbstractOrganic BF2complexes exhibit characteristics such as large Stokes shift, high quantum yield, strong emission intensity, and robust chemical stability, thereby being extensively used in various applications. Herein, we disclose a novel copper‐catalyzed cascade C−H activation/acyloxylation and difluoroboronation of 2‐phenylpyridine derivatives, thus providing a straightforward and rapid gateway to a series of N,O‐bidentate organic BF2complexes with excellent photophysical properties. Mechanism studies demonstrate that AgBF4services as BF2source and oxidant for this elegant transformation. Most of these BF2complexes have broad and intense absorption and emission bands, and display bright and intensive blue fluorescence as well as large Stokes shifts.