bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CPPS based on GBDT for predicting failure events in milling
Authors: Zhang Y. , Beudaert X. , Argandoña J. , Ratchev S. , Munoa J. 
Published: September 2020

AbstractCyber-physical production systems (CPPS) are mechatronic systems monitored and controlled by software brains and digital information. Despite its fast development along with the advancement of Industry 4.0 paradigms, an adaptive monitoring system remains challenging when considering integration with traditional manufacturing factories. In this paper, a failure predictive tool is developed and implemented. The predictive mechanism, underpinned by a hybrid model of the dynamic principal component analysis and the gradient boosting decision trees, is capable of anticipating the production stop before one occurs. The proposed methodology is implemented and experimented on a repetitive milling process hosted in a real-world CPPS hub. The online testing results have shown the accuracy of the predicted production failures using the proposed predictive tool is as high as 73% measured by the AUC score.
The co-occurrence of a four-headed coracobrachialis muscle, split coracoid process and tunnel for the median and musculocutaneous nerves: the potential clinical relevance of a very rare variation
Authors: Olewnik Łukasz , Zielinska Nicol , Karauda Piotr , Duparc Fabrice , Georgiev Georgi P. , Polguj Michał 
Published: September 2020

AbstractThe coracobrachialis muscle (CBM) originates from the apex of the coracoid process, in common with the short head of the biceps brachii muscle, and from the intermuscular septum. Both the proximal and distal attachment of the CBM, as well as its relationship with the musculocutaneus nerve demonstrate morphological variability, some of which can lead to many diseases. The present case study presents a new description of a complex origin type (four-headed CBM), as well as the fusion of both the short biceps brachii head, brachialis muscle and medial head of the triceps brachii. In addition, the first and second heads formed a tunnel for the musculocutaneus and median nerves. This case report has clear clinical value due to the split mature of the coracoid process, and is a significant indicator of the development of interest in this overlooked muscle.
Effects of organic mercury on Mytilus galloprovincialis hemocyte function and morphology
Authors: Parisi Maria Giovanna , Pirrera Jessica , La Corte Claudia , Dara Mariano , Parrinello Daniela , Cammarata Matteo 
Published: September 2020

Abstract
Filter-feeding organisms accumulate xenobiotics and other substances in their tissues. They can be useful as sentinel organisms in biomonitoring of the marine compartment. Bivalve cellular immunity is ensured by phagocytosis and cytotoxic reactions carried out by hemocytes in a network with humoral responses. These can be affected by chemical contaminants in water that can be immunosuppressors also at a low concentration increasing the sensibility to pathogens. This work is an attempt to individuate cellular markers for pollution detection, investigating the effect of methylmercury (CH3HgCl) at different concentrations on the activity and hemocyte morphology of the Mediterranean mussel, Mytilus galloprovincialis. We assessed the effect of three sub-lethal concentrations of the organometal on the cellular morphology, the efficacy of phagocytosis toward yeast cells, the alteration of the lysosomal membrane and the ability to release cytotoxic molecules. The results provide information on the alteration of hemocyte viability, modification of the morphological and cytoskeletal features and besides the cellular spreading, intrinsic ability of motile cells was used as a complementary investigation method. Exposure to the contaminant affected the percentage of phagocytosis and the phagocytosis index. Moreover, morphological and cytoskeleton alteration, caused by the pollutant, leads to reduced ability to incorporate the target and adhere to the substrate and the low ability of cells to retain neutral red could depend on the effects of methylmercury on membrane permeability. These results reinforce the use of the Mediterranean mussel as model for the evaluation of environmental quality in aquatic ecosystems integrating the novel information about hemocyte functions and morphology sensibility to organic mercury.

Graphic abstract
The impact of endometrioma on in vitro fertilisation/intra-cytoplasmic injection IVF/ICSI reproductive outcomes: a systematic review and meta-analysis
Authors: Alshehre Sallwa M. , Narice Brenda F. , Fenwick Mark A. , Metwally Mostafa 
Published: September 2020

Abstract
Background
Assisted reproductive technologies (ART) such as in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) are often used to aid fertility in women with endometrioma; however, the implications of endometrioma on ART are unresolved.

Objective
To determine the effect of endometrioma on reproductive outcomes in women undergoing IVF or ICSI.

Methods
A systematic review and meta-analysis was conducted to identify articles examining women who had endometrioma and had undergone IVF or ICSI. Electronic searches were performed in PubMed, BIOSIS and MEDLINE up to September 2019. The primary outcome was live birth rate (LBR). Secondary outcomes included clinical pregnancy rate (CPR), implantation rate (IR), number of oocytes retrieved, number of metaphase II (MII) oocytes retrieved, number of embryos and top-quality embryos and the duration of gonadotrophin stimulation and dose.

Results
Eight studies were included. Where significant heterogeneity between studies was identified, a random-effects model was used. The number of oocytes (weighted means difference; WMD-2.25; 95% CI 3.43 to − 1.06, p = 0.0002) and the number of MII oocytes retrieved (WMD-4.64; 95% CI 5.65 to − 3.63, p < 0.00001) were significantly lower in women with endometrioma versus controls. All other outcomes, including gonadotrophin dose and duration, the total number of embryos, high-quality embryos, CPR, IR and LBR were similar in women with and without endometrioma.

Conclusion
Even though women with endometriomas had a reduced number of oocytes and MII oocytes retrieved when compared to women without, no other differences in reproductive outcomes were identified. This implies that IVF/ICSI is a beneficial ART approach for women with endometrioma.
Cognitive control in number processing: new evidence from task switching
Authors: Schliephake Andreas , Bahnmueller J. , Willmes K. , Moeller K. 
Published: September 2020

AbstractRecently, it was demonstrated that even basic numerical cognition such as the processing of number magnitude is under cognitive control. However, evidence so far primarily came from adaptation effects to stimulus characteristics (e.g., relative frequency of specific stimulus categories). Expanding this approach, we evaluated a possible influence of more active exertion of cognitive control on basic number processing in task switching. Participants had to perform a magnitude comparison task while we manipulated the order of compatible and incompatible input–output modalities (i.e., auditory/vocal input–visual/manual output vs. auditory/visual input–manual/vocal output, respectively) on the trial level, differentiating repeat vs. switch trials. Results indicated that the numerical distance effect but not the problem size effect was increased after a switch in input–output modality compatibility. In sum, these findings substantiate that basic number processing is under cognitive control by providing first evidence that it is influenced by the active exertion of cognitive control as required in task switching.
Masterplan 2025 der Österreichischen Gesellschaft für Pneumologie (ÖGP) – die erwartete Entwicklung und Versorgung respiratorischer Erkrankungen in Österreich
Authors: Studnicka Michael , Baumgartner Bernhard , Bolitschek Josef , Doberer Daniel , Eber Ernst , Eckmayr Josef , Hartl Sylvia , Hesse Peter , Jaksch Peter , Kink Eveline , Kneussl Meinhard , Lamprecht Bernd , Olschewski Horst , Pfleger Andreas , Pohl Wolfgang , Prior Christian , Puelacher Christoph , Renner Andreas , Steflitsch Wolfgang , Stelzmüller Ingrid , Täubl Helmut , Vonbank Karin , Wagner Marlies , Wantke Felix , Wass Romana 
Published: September 2020

ZusammenfassungMitglieder der Österreichischen Gesellschaft für Pneumologie (ÖGP) beschreiben die erwartete Entwicklung der respiratorischen Gesundheit und zeigen Wege einer patientenorientierten und kosteneffizienten Versorgung für Österreich auf.Methoden: Im November 2017 trifft sich eine Gruppe von respiratorisch tätigen Ärzten, Pflegekräften und Physiotherapeuten, gemeinsam mit Vertretern von Selbsthilfe-Gruppen und Experten für Gesundheitsentwicklung, um die Themen Rahmenbedingungen für Lungengesundheit, Asthma und Allergie, COPD, Mukoviszidose und andere Krankheitsbilder der pädiatrischen Pneumologie, Infektionen in der Pneumologie, Schlafbezogene Atemstörungen, Interventionelle Pneumologie, Thorakale Onkologie, und Orphan Diseases zu bearbeiten.Ergebnisse: Respiratorische Erkrankungen sind extrem häufig und werden sehr oft durch individuelles Fehlverhalten (Zigarettenrauchen, Überernährung, körperliche Inaktivität) verursacht. Zudem wird für respiratorische Erkrankungen eine Zunahme der Prävalenz, aber eine Abnahme der Hospitalisierungen erwartet. Folgende Maßnahmen sind erforderlich, um den Herausforderungen der Zukunft zu begegnen.1. Maßnahmen des Screenings und der Fallfindung sollen für Lungenkarzinom und COPD umgesetzt werden.2. E-Health (Telemedizin, personalisierte Apps) soll vermehrt eingesetzt werden mit dem Ziel das Patientenmanagement zu erleichtern.3. Regionale Unterschiede der medizinischen Versorgung können durch E‑Health und Harmonisierung der Angebote der Gesundheitskassen reduziert werden.4. Patientenschulung und Awareness für respiratorische Erkrankungen soll verbessert werden (essentiell für Schlafstörungen, aber auch für andere respiratorische Erkrankungen)5. Die angebotene Versorgung soll interprofessionell, und auf der Grundlage erkrankungsspezifischer Boards wie bei Tumorboards (z. B. für interstitielle Lungenerkrankungen, Schlaf und Allergie) erfolgen.6. Die ambulante Rehabilitation im niedergelassenen Bereich kann einen großen Beitrag zur respiratorischen Gesundheit leisten.7. Das vermehrte Verständnis der Molekularbiologie wird die personalisierte Medizin und zielgerichtete Therapien (z. B. für Asthma, Lungenkarzinom) ermöglichen, aber auch Gesundheitskosten verändern.
User-defined semantics for the design of IoT systems enabling smart interactive experiences
Authors: Ardito Carmelo , Desolda Giuseppe , Lanzilotti Rosa , Malizia Alessio , Matera Maristella , Buono Paolo , Piccinno Antonio 
Published: September 2020

AbstractAutomation in computing systems has always been considered a valuable solution to unburden the user. Internet of Things (IoT) technology best suits automation in different domains, such as home automation, retail, industry, and transportation, to name but a few. While these domains are strongly characterized by implicit user interaction, more recently, automation has been adopted also for the provision of interactive and immersive experiences that actively involve the users. IoT technology thus becomes the key for Smart Interactive Experiences (SIEs), i.e., immersive automated experiences created by orchestrating different devices to enable smart environments to fluidly react to the final users’ behavior. There are domains, e.g., cultural heritage, where these systems and the SIEs can support and provide several benefits. However, experts of such domains, while intrigued by the opportunity to induce SIEs, are facing tough challenges in their everyday work activities when they are required to automate and orchestrate IoT devices without the necessary coding skills. This paper presents a design approach that tries to overcome these difficulties thanks to the adoption of ontologies for defining Event-Condition-Action rules. More specifically, the approach enables domain experts to identify and specify properties of IoT devices through a user-defined semantics that, being closer to the domain experts’ background, facilitates them in automating the IoT devices behavior. We also present a study comparing three different interaction paradigms conceived to support the specification of user-defined semantics through a “transparent” use of ontologies. Based on the results of this study, we work out some lessons learned on how the proposed paradigms help domain experts express their semantics, which in turn facilitates the creation of interactive applications enabling SIEs.
The hybrid models, containing hydrolytic and electron-driven processes, in theoretical study of oxaliplatin biotransformation
Authors: Kuduk-Jaworska Janina , Jański Jerzy J. , Roszak Szczepan 
Published: September 2020

AbstractThe results of theoretical simulations of reaction paths for oxaliplatin from pro-drug into its active form responsible for cytostatic effect are presented. The studies based on the quantum-chemical density functional theory approach were performed considering environmental influence resulting from the aquation or electron donation. The hybrid mechanisms: hydrolytic mixed with electron driven were found to be the energetically favourable.
Water exchange between the inner and outer archipelago areas of the Finnish Archipelago Sea in the Baltic Sea
Authors: Miettunen Elina , Tuomi Laura , Myrberg Kai 
Published: September 2020

AbstractWe studied the water age and transport of passive tracers in the Archipelago Sea, Baltic Sea, using the COHERENS 3D hydrodynamic model and the OpenDrift Lagrangian particle model. The mean water age, which was calculated with COHERENS over a period of 6 years, varied between 1 and 3 months in the outer archipelago and between 3 and 6 months in the middle archipelago. The water age was highest in the inner archipelago, up to 7 months. As the density stratification is weak in large parts of this area, except for the seasonal thermocline, significant differences in the water age between the surface and bottom layers were seen only in the river mouths and in the deep channels of the middle archipelago. The Lagrangian particle simulations showed that the middle archipelago is more open towards the north than south. From the northern boundary, the Bothnian Sea, the largest transport to the middle archipelago occurred with NW winds. Due to the geometry and density of the islands in the area, the prevailing wind direction, SW, alone is not optimal for transporting tracer particles to the middle archipelago. From the southern boundary, the Baltic Proper, transport to the middle archipelago occurred mainly with SE winds and during events when the wind direction shifted from SW to SE or vice versa. The transport further into the inner archipelago was limited to only a few cases, indicating that the inner archipelago is fairly sheltered from transport from the outer archipelago.
Quantitative imaging of gas adsorption equilibrium and dynamics by X-ray computed tomography
Authors: Pini Ronny , Joss Lisa , Hosseinzadeh Hejazi Sayed Alireza 
Published: September 2020

AbstractWe present the development and application of X-ray Computed Tomography (CT) for the determination of the adsorption properties of microporous adsorbents and the study of breakthrough experiments in a laboratory fixed-bed adsorption column. Using the model system$$\text {CO}_2/\text {helium}$$CO2/heliumon activated carbon, equilibrium and dynamic adsorption/desorption measurements by X-ray CT are described, and the results are successfully compared to those obtained from conventional methods, including the application of a one-dimensional dynamic column breakthrough model. The study demonstrates the practical feasibility of applying X-ray CT to measure internal and transient concentration profiles in adsorbent systems on the length-scales from a single adsorbent pellet to a packed column.
Therapeutic Potential of Senolytics in Cardiovascular Disease
Authors: Dookun Emily , Passos João F. , Arthur Helen M. , Richardson Gavin D. 
Published: September 2020

AbstractAgeing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction. Furthermore, ageing is associated with a poorer prognosis to these diseases. Genetic models allowing the elimination of senescent cells revealed that an accumulation of senescence contributes to the pathophysiology of cardiovascular ageing and promotes the progression of cardiovascular disease through the expression of a proinflammatory and profibrotic senescence-associated secretory phenotype. These studies have resulted in an effort to identify pharmacological therapeutics that enable the specific elimination of senescent cells through apoptosis induction. These senescent cell apoptosis-inducing compounds are termed senolytics and their potential to ameliorate age-associated cardiovascular disease is the focus of this review.
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart
Authors: Park Min , Nishimura Takanori , Baeza-Garza Carlos D. , Caldwell Stuart T. , Pun Pamela Boon Li , Prag Hiran A. , Young Tim , Sauchanka Olga , Logan Angela , Forkink Marleen , Gruszczyk Anja V. , Prime Tracy A. , Arndt Sabine , Naudi Alba , Pamplona Reinald , Coughlan Melinda T. , Tate Mitchel , Ritchie Rebecca H. , Caicci Federico , Kaludercic Nina , Di Lisa Fabio , Smith Robin A. J. , Hartley Richard C. , Murphy Michael P. , Krieg Thomas 
Published: September 2020

Abstract
Purpose
HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used it to confirm the therapeutic efficacy of the mitochondria-targeted dicarbonyl scavenger, MitoGamide.

Methods and Results
A longitudinal echocardiographic analysis confirmed that Akita mice develop diastolic dysfunction with reduced E peak velocity, E/A ratio and extended isovolumetric relaxation time (IVRT), while the systolic function remains comparable with wild-type mice. The myocardium of Akita mice had a decreased ATP/ADP ratio, elevated mitochondrial oxidative stress and increased organelle density, compared with that of wild-type mice. MitoGamide, a mitochondria-targeted 1,2-dicarbonyl scavenger, exhibited good stability in vivo, uptake into cells and mitochondria and reactivity with dicarbonyls. Treatment of Akita mice with MitoGamide for 12 weeks significantly improved the E/A ratio compared with the vehicle-treated group.

Conclusion
Our work confirms that the Akita mouse model of diabetes replicates key clinical features of diabetic HFpEF, including cardiac and mitochondrial dysfunction. Furthermore, in this independent study, MitoGamide treatment improved diastolic function in Akita mice.
Effect of Environmental Conditions on the Dehydration and Performance of Fire-Protective Gels
Authors: Kadel Jacob , Hedayati Faraz , Quarles Stephen L. , Zhou Aixi 
Published: September 2020

AbstractDuring wildfire events fire-protective gels can be used as a line of defense to protect structures. The effectiveness of freshly applied gels in delaying ignition and flame growth on structures has been well established. However, in a real-world scenario there is a period between the application of the gel and the arrival of a spot fire or the fire-front. During this period, the gels are often exposed to extreme conditions consisting of high winds and low relative humidity. The effect of these weathering conditions on the performance of fire-protective gels is still poorly understood. This study examined the dehydration and performance of fire-protective gels following a range of weathering conditions. Two commercially available gels were applied to a 100-mm by 100-mm T1-11 plywood sample and then artificially weathered in an environmental chamber, with controlled temperature, relative humidity, and wind. The remaining mass of the gels was measured at selected intervals to determine the relationship between mass loss and dehydration related to weathering. A second series of tests was conducted on weathered T1-11 samples at specific mass loss states as well as on freshly applied gels using a 50 kW/m2 heat flux exposure utilizing a cone calorimeter. Results indicated that they dehydrated to the point where, after 3 h, fire performance was no better than the uncoated wood samples and the gels could facilitate ignition. This timeline suggests that gels should only be applied by first responders and homeowners should focus on evacuation related activities.
Autonomic Management Framework for Cloud-Native Applications
Authors: Kosińska Joanna , Zieliński Krzysztof 
Published: September 2020

AbstractIn order to meet the rapidly changing requirements of the Cloud-native dynamic execution environment, without human support and without the need to continually improve one’s skills, autonomic features need to be added. Embracing automation at every layer of performance management enables us to reduce costs while improving outcomes. The main contribution of this paper is the definition of autonomic management requirements of Cloud-native applications. We propose that the automation is achieved via high-level policies. In turn autonomy features are accomplished via the rule engine support. First, the paper presents the engineering perspective of building a framework for Autonomic Management of Cloud-Native Applications, namely AMoCNA, in accordance with Model Driven Architecture (MDA) concepts. AMoCNA has many desirable features whose main goal is to reduce the complexity of managing Cloud-native applications. The presented models are, in fact, meta-models, being technology agnostic. Secondly, the paper demonstrates one possibility of implementing the aforementioned design procedures. The presented AMoCNA implementation is also evaluated to identify the potential overhead introduced by the framework.