bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carp (Cyprinidae) Fisheries in Swedish Lakes: A Combined Environmental Assessment Approach to Evaluate Data-limited Freshwater Fish Resources as Food
Authors: Hornborg Sara , Främberg Anton 
Published: December 2019

AbstractThe role of aquatic resources to food security is both promising and constrained since the global seafood consumption is increasing while marine fisheries approach the limit of what it can produce. In Sweden, the seafood consumption per capita is higher than the European and world average but the current dietary advice is to increase consumption. Freshwater fisheries have in general been paid less attention in food security discussions. Carp fishes (Cyprinidae) in Sweden have lost their historical value and are currently, both understudied and underutilized. Here we use a combined environmental assessment approach to examine the environmental sustainability of current and potential cyprinid fisheries. We found that current commercial fisheries for Swedish cyprinids in lakes have an average carbon footprint of 0.77 kg CO2e per kg of edible product, substantially smaller than most of the popular marine and terrestrial protein sources consumed in Sweden today. This could be even lower if cyprinid resources were better utilized than currently. The cyprinids however exhibited different vulnerability to fishing pressure and are today associated with data deficiencies. Hence, it is currently uncertain how much food for human consumption they can contribute to. Improved consumer interest and management attention is needed, but to the Swedish diet, cyprinids offer a promising opportunity for future more sustainable and nutritious food systems.
Lack of insulin resistance in response to streptozotocin treatment in neuronal SH-SY5Y cell line
Authors: Bagaméry Fruzsina , Varga Kamilla , Kecsmár Kitti , Vincze István , Szökő Éva , Tábi Tamás 
Published: December 2019

AbstractRecently, it is suggested that brain insulin resistance may contribute to the development of Alzheimer’s disease; therefore, there is a high interest in its investigation. Streptozotocin (STZ) is often used to induce dysregulation of glucose and insulin metabolism in animal and cell culture models. Alteration in insulin sensitivity however, has not yet been assessed in neuronal cells after STZ treatment. We aimed at studying the concentration dependence of the protective effect of insulin on STZ-induced damage using SH-SY5Y cell line. Cells were treated with STZ and cell viability was assessed by resazurin reduction and lactate dehydrogenase release assays. Low serum (LS) medium was used as control damage. The effect of various concentrations (30, 100, 300, 1000 nM) of insulin was studied on cell viability and glycogen synthase kinase-3 (GSK-3) phosphorylation, an indicator of insulin signaling. STZ induced dose- and time-dependent cytotoxicity, its 1 mM concentration exerted a low, gradually developing damage. The cytoprotective effect of insulin was demonstrated in both STZ and LS groups. Its maximal effect was lower in the STZ-treated cells; however, its effective concentration remained largely unaltered. Insulin-induced GSK-3 phosphorylation was similar in the STZ- and LS-treated cells suggesting unchanged insulin signaling. Our present results indicate that STZ does not induce significant impairment in insulin sensitivity in SH-SY5Y cells, thus in this cell line it is not a good tool for studying the role of insulin resistance in neurodegeneration and to examine protective agents acting by improving insulin signaling.
Analysis of anti-RNA polymerase III antibodies in Chinese Han systemic sclerosis patients
Authors: Liu Chenxi , Hou Yong , Xu Dong , Li Liubing , Zhang Yanfang , Cheng Linlin , Yan Songxin , Zhang Fengchun , Li Yongzhe 
Published: December 2019

Abstract
Objectives
This study aimed to assess the prevalence and clinical correlation of anti-RNA polymerase III antibodies (anti-RNAP III) in Chinese Han systemic sclerosis (SSc) patients.

Methods
Serum samples from 236 patients with SSc, 125 patients with connective tissue diseases (CTD), and 166 healthy controls (HCs), recruited from Peking Union Medical College Hospital and 21 other medical centers in China, were tested for antibodies to RNA polymerase III by means of a line immunoassay (LIA) or an enzyme-linked immunosorbent assay (ELISA) kit.

Results
Anti-RNAP III antibodies were found in 14/236 SSc patients (5.93%), 1/125 (0.80%) CTD patients, and 0/166 (0.00%) HCs. The prevalence of anti-RNAP III was higher in SSc patients than in the CTD and HC groups (p = 0.02, p = 0.001, respectively). Renal crisis was significantly more common in patients with anti-RNAP III than patients without anti-RNAP III (42.9 vs. 4.1%, p < 0.0001). Gastrointestinal involvement was significantly more common in patients without anti-RNAP III than patients with anti-RNAP III (53.6 vs. 21.4%, p = 0.039). There was good agreement between the ELISA and line immunoassay (LIA) detection capabilities for anti-RNAP III.

Conclusions
The anti-RNAP III antibody, which was detected by ELISA, has diagnostic value for SSc and predictive value for SSc-related renal crisis. Both ELISA and LIA are very reliable methods for anti-RNAP III.Key Points• The prevalence of anti-RNAP III antibody was determined in Chinese SSc patients and performed ethnic differences.• The clinical association between anti-RNAP III antibody and Chinese SSc patients was evaluated in this research.• Methodological consistency of detection of anti-RNAP III antibody using commercial ELISA and LIA methods was evaluated in this research.
An “all-wheel drive” proposal to accelerate clinical research in common and rare neurological diseases
Authors: Salvetti Marco , Battaglia Mario A. , Di Filippo Massimiliano , Mancardi Gian Luigi , Mancuso Michelangelo , Patti Francesco , Sormani Maria Pia , Zaratin Paola 
Published: December 2019

AbstractThe complex biology of neurological diseases calls for collaborative efforts that may increase the success rate of clinical research. Models have been proposed, but concrete actions remain insufficient. Based on recent considerations from basic science, from science of patient input and from an analysis of scientific resources in Italy, we here explain why our country may represent an appropriate environment for such actions. Furthermore, we sketch operational framework and business model to be applied in order to accelerate, in parallel, the development of therapies in common and rare diseases.
Investigations on hepatic and intestinal drug-metabolizing cytochrome P450 enzymes in wild boar compared to domestic swine
Authors: Kurucz Ádám , Orbán Kata , Mackei Máté , Fébel Hedvig , Neogrády Zsuzsanna , Mátis Gábor 
Published: December 2019

AbstractDrug-metabolizing cytochrome P450 (CYP) enzymes are especially important in wild animals as they are directly exposed to environmental pollutants and bioactive molecules of plants. Our main goal was to monitor the activity of certain CYP enzymes in wild boar compared to domestic swine, and to assess various modulatory factors of xenobiotic biotransformation in wild boar. Liver and intestinal mucosa (duodenum, jejunum, ileum, caecum) samples were collected from 49 hunted free-range wild boars and 15 wild boar fetuses; domestic pig samples (n = 40) were gained from a slaughter house. Specific activity of CYP1A2, CYP2C9, and CYP3A4 enzymes was assessed by luminometric assays. The activity of hepatic CYP1A2 and CYP3A4 enzymes was significantly higher in wild boars than in domestic pigs, while CYP2C9-mediated hepatic metabolism was significantly less intense in wild boars than in pigs. Certain modulatory factors (sex, sexual maturation, and season) were also confirmed in wild boars. The activity of all investigated intestinal CYP enzymes remained under detection level in each gut section in both species. Hepatic CYP2C9 and CYP3A4 enzymes were measurable in wild boar fetuses, but their activity was remarkably lower than in adults. The described interspecies differences might be explained with the altered exposure of wild and domesticated animals to specific CYP modulators. As CYP enzymes in wild boars can be highly influenced by environmental pollutants, following further studies, they may serve as ecotoxicological markers of agricultural or industrial toxicants. Investigating CYP-related drug metabolism in wildlife species can clarify some toxicokinetic interactions, thus having huge importance in the production of safe game meat.
Transitional Flow Dynamics Behind a Micro-Ramp
Authors: Casacuberta J. , Groot K. J. , Ye Q. , Hickel S. 
Published: December 2019

AbstractMicro-ramps are popular passive flow control devices which can delay flow separation by re-energising the lower portion of the boundary layer. We compute the laminar base flow, the instantaneous transitional flow, and the mean flow around a micro-ramp immersed in a quasi-incompressible boundary layer at supercritical roughness Reynolds number. Results of our Direct Numerical Simulations (DNS) are compared with results of BiLocal stability analysis on the DNS base flow and independent tomographic Particle Image Velocimetry (tomo-PIV) experiments. We analyse relevant flow structures developing in the micro-ramp wake and assess their role in the micro-ramp functionality, i.e., in increasing the near-wall momentum. The main flow feature of the base flow is a pair of streamwise counter-rotating vortices induced by the micro-ramp, the so-called primary vortex pair. In the instantaneous transitional flow, the primary vortex pair breaks up into large-scale hairpin vortices, which arise due to linear varicose instability of the base flow, and unsteady secondary vortices develop. Instantaneous vortical structures obtained by DNS and experiments are in good agreement. Matching linear disturbance growth rates from DNS and linear stability analysis are obtained until eight micro-ramp heights downstream of the micro-ramp. For the setup considered in this article, we show that the working principle of the micro-ramp is different from that of classical vortex generators; we find that transitional perturbations are more efficient in increasing the near-wall momentum in the mean flow than the laminar primary vortices in the base flow.
Structure of the Condensed Phase in the Inclusion Process
Authors: Jatuviriyapornchai Watthanan , Chleboun Paul , Grosskinsky Stefan 
Published: December 2019

AbstractWe establish a complete picture of condensation in the inclusion process in the thermodynamic limit with vanishing diffusion, covering all scaling regimes of the diffusion parameter and including large deviation results for the maximum occupation number. We make use of size-biased sampling to study the structure of the condensed phase, which can extend over more than one lattice site and exhibit an interesting hierarchical structure characterized by the Poisson–Dirichlet distribution. While this approach is established in other areas including population genetics or random permutations, we show that it also provides a powerful tool to analyse homogeneous condensation in stochastic particle systems with stationary product distributions. We discuss the main mechanisms beyond inclusion processes that lead to the interesting structure of the condensed phase, and the connection to other generic particle systems. Our results are exact, and we present Monte-Carlo simulation data and recursive numerics for partition functions to illustrate the main points.
Managing daytime sleepiness with the help of sleepcoaching, a non-pharmacological treatment of non-restorative sleep
Authors: Holzinger Brigitte , Levec Katharina , Munzinger Melissa-Marie , Mayer Lucille , Klösch Gerhard 
Published: December 2019

Abstract
Purpose
To measure the effect of a 2-day sleepcoaching seminar on daytime sleepiness and sleep-related variables of shift workers employed in an Austrian railway company (ÖBB: Österreichische Bundesbahnen).

Method
Participants filled in pre- and post-intervention questionnaires, containing items of the PSQI and the ESS, questions about chronotype, personality factors and possible burnout risk factors. About 30 shift workers, working in shifts for more than 300 months on average (28 male; mean age = 24 ± 45.90, age range 24–56 years) voluntarily took part in the investigation twice. Sleep coaching by Holzinger and Kloesch™ (SC) is a new holistic approach for non-pharmacological treatment of non-restorative sleep and is based on Gestalt therapy. It includes psychotherapeutic aspects, which enable clients to improve their sleep quality by developing one’s own coping strategies which can be implemented in daily routine. Dream work and relaxation techniques are also part of the programme.

Results
The 2-day SC seminar was beneficial by focusing on the sleep problems related to shift work. A significant improvement of the global PSQI score and the PSQI variables subjective sleep quality, diurnal fatigue, and sleep latency was achieved, with a medium effect size. However, the programme did not result in the reduction of daytime sleepiness (ESS). Six more variables did not change significantly.

Conclusion
While some sleep problems related to shift work were successfully addressed by SC, daytime sleepiness (ESS) could not be reduced contrary to our expectations. More research with a greater sample and a longitudinal design is needed to examine the long-term effects of SC.
Three principles for co-designing sustainability intervention strategies: Experiences from Southern Transylvania
Authors: Lam David P. M. , Horcea-Milcu Andra I. , Fischer Joern , Peukert Daniela , Lang Daniel J. 
Published: December 2019

AbstractTransformational research frameworks provide understanding and guidance for fostering change towards sustainability. They comprise stages of system understanding, visioning and co-designing intervention strategies to foster change. Guidance and empirical examples for how to facilitate the process of co-designing intervention strategies in real-world contexts remain scarce, especially with regard to integrating local initiatives. We suggest three principles to facilitate the process of co-designing intervention strategies that integrate local initiatives: (1) Explore existing and envisioned initiatives fostering change towards the desired future; (2) Frame the intervention strategy to bridge the gap between the present state and desired future state(s), building on, strengthening and complementing existing initiatives; (3) Identify drivers, barriers and potential leverage points for how to accelerate progress towards sustainability. We illustrate our approach via a case study on sustainable development in Southern Transylvania. We conclude that our principles were useful in the case study, especially with regards to integrating initiatives, and could also be applied in other real-world contexts.
Timing is key to providing modified assessments for students with specific learning difficulties
Authors: Gray Christian P , Burr Steven A 
Published: December 2019

Introduction Medical students who are diagnosed with a specific learning difficulty (SpLD) will typically receive a reasonable adjustment within examinations in the form of modified assessment provision (MAP). This study investigated whether the timing of SpLD diagnosis and subsequent implementation of MAP has an impact on performance in applied medical knowledge multiple choice question (MCQ) assessments.
Method The MCQ performance of 108 students diagnosed with SpLD who received a MAP was monitored and compared with 1960 students who received an unmodified assessment, over 5 years of a medical program. Students who received a SpLD diagnosis in the latter years of the program were identified as not receiving a MAP in assessments prior to diagnosis.
Results Differences were found between declaration and diagnosis, with 44.4% of students who declared and 48.1% who did not declare subsequently receiving a diagnosis. Students with SpLD who receive a MAP increase their applied medical knowledge assessment performance, although there is a delay of up to a year for this impact to reach significance.
Conclusion Early diagnosis of SpLD is necessary to ensure the intended benefit is received from MAP.
Bi2S3 for Aqueous Zn Ion Battery with Enhanced Cycle Stability
Authors: Xiong Ting , Wang Yinming , Yin Bosi , Shi Wen , Lee Wee Siang Vincent , Xue Junmin 
Published: December 2019

AbstractAqueous Zn ion batteries (ZIBs) are promising in energy storage due to the low cost, high safety, and material abundance. The development of metal oxides as the cathode for ZIBs is limited by the strong electrostatic forces between O2− and Zn2+ which leads to poor cyclic stability. Herein, Bi2S3 is proposed as a promising cathode material for rechargeable aqueous ZIBs. Improved cyclic stability and fast diffusion of Zn2+ is observed. Also, the layered structure of Bi2S3 with the weak van der Waals interaction between layers offers paths for diffusion and occupancy of Zn2+. As a result, the Zn/Bi2S3 battery delivers high capacity of 161 mAh g−1 at 0.2 A g−1 and good cycling stability up to 100 cycles with ca. 100% retention. The battery also demonstrates good cyclic performance of ca. 80.3% over 2000 cycles at 1 A g−1. The storage mechanism in the Bi2S3 cathode is related to the reversible Zn ion intercalation/extraction reactions and the capacitive contribution. This work indicates that Bi2S3 shows great potential as the cathode of ZIBs with good performance and stability.
Field assessment of a safe sleep instrument using smartphone technology
Authors: Nabaweesi Rosemary , Whiteside-Mansell Leanne , Mullins Samantha H. , Rettiganti Mallikarjuna R. , Aitken Mary E. 
Published: December 2019

AbstractIntroduction:Sudden unexpected infant death is the leading cause of infant mortality with black: white infant mortality remaining at 2:1 for the last decade. Smartphone technology provides a convenient and accessible tool for injury prevention anticipatory guidance among at-risk communities.Materials and Methods:A convenience sample of pregnant teen mothers who own a smartphone. During a 1-month postnatal home visit, a safe sleep environment survey was administered, infant sleep practices were observed, and mothers trained to take and submit standard infants’ sleep environment photographs. Photographs were independently assessed for inter-rater reliability (IRR) across five sleep safety domains (primary outcome): sleep location, surface, position, presence of soft items, and hazards near the sleep area. Expert and novice coders IRR was measured using Cohen’s kappa coefficient (K). Sleep safety correlation between photographs and observation, and parent report and observation was determined.Results:Sixteen (57.1%) mothers completed the home visit. Most parents reported infants sleeping supine (78.5) in parents’ bedroom (85.9%). Photographs demonstrated sleep position, soft items without the baby present, and hanging toys had perfect agreement across all three coder pairs. Safe sleep experts’ IRR demonstrated perfect agreement for sleep location, position, and soft items. While 83.8% of parents were observed putting their infants down to sleep on their back, 78.5% of parents reported doing the same and 82.4% of the photographs demonstrated supine infant sleep position.Conclusion:Using photographs, coders can reliably categorize some key infant sleep safety aspects, and photograph sleep safety is comparable to parent report and direct observation.
FROM LAW TO DHARMA: STATE LAW AND SACRED DUTY IN ANCIENT INDIA
Authors: McClish Mark 
Published: December 2019

AbstractThe legal treatises of ancient India, called Dharmaśāstras, are often read as records of the initial emergence of law from religion in South Asia. The Dharmaśāstras teach the dharma, or “sacred duty,” of different members of society. It is one of the dharmas of the king to adjudicate disputes that come before his courts, and it is widely accepted that a need to articulate the king's dharma led the composers of the Dharmaśāstras over time to fashion rules for state courts, a body of law called vyavahāra. Scholars such as Henry Sumner Maine and Max Weber saw in the Dharmaśāstras evidence of the disentanglement and rationalization of law, respectively. A close examination of our sources, however, shows that the law of royal courts emerged not within the Dharmaśāstra tradition, but within an adjacent and decidedly more secular tradition of statecraft. It was gradually absorbed into Dharmaśāstra texts, where it was reconfigured as sacred duty and its historical origins were obscured. This article argues that the early history of state law in India is best described, therefore, not as a transition from dharma to law, but as a transition from law to dharma.
An interprofessional perspective on healthcare work: physicians and nurses co-constructing identities and spaces of action
Authors: Lokatt Erika , Holgersson Charlotte , Lindgren Monica , Packendorff Johann , Hagander Louise 
Published: December 2019

AbstractIn this article we develop a theoretical perspective of how professional identities in multi-professional organisational settings are co-constructed in daily interactions. The research reported here is located in a healthcare context where overlapping knowledge bases, unclear divisions of responsibilities, and an increased managerialist emphasis on teamwork make interprofessional boundaries in healthcare operations more complex and blurred than ever. We thereby build on a research tradition that recognises the healthcare sector as a negotiated order, specifically studying how professional identities are invoked, constructed, and re-constructed in everyday work interactions. The perspective is employed in an analysis of qualitative data from interviews and participant observation at a large Swedish hospital, in which we find three main processes in the construction of space of action: hierarchical, inclusive, and pseudo-inclusive. In most of the interactions, existing inter-professional divides and power relations are sustained, preventing developments towards integrated interprofessional teamwork.
Karlheinz Stockhausen, aus LICHT, Holland Festival, 31 May–10 June 2019.
Authors: Erwin Max 
Published: December 2019

Why Karl Heinz [sic] Stockhausen entitled his music for oboe, bass clarinet, piano, and four percussionists Kreuzspiel is incomprehensible. Following a system of ‘static music’, the indefensibleness of which Theodor Adorno already demonstrated the previous year to its Flemish inventor, the sound of the piece goes far beyond that which we have been accustomed to call music. That he finds a few devotees to celebrate his work … doesn't change things a jot. Every idea finds its prophets. And its sect.Albert Rodemann, Darmstädter Tagblatt, 23 July 1952.Quoted and translated in Martin Iddon, New Music at Darmstadt, 84–85.
In February 1971, so the story goes, a barefooted figure with a wizard's staff handed Karlheinz Stockhausen a copy of the Urantia Book, a dense, hugely esoteric text describing the spiritual place of mankind in the universe through chapters like ‘Socializing Influence of Ghost Fear’. Most people would probably have politely thanked the figure and then escaped as quickly as possible, but this is Stockhausen we're talking about, so he devoted the rest of his life to transforming Urantia into ‘music, libretto, dance, actions and movements’, as the programme to aus LICHT credits him.