bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clínica neurológica fluctuante: ¿Llamo al neurólogo o al hematólogo?
Authors: Losa-Rodríguez Rita , Pérez Martínez Carmen , Rodríguez Pérez Gabriel , de la Fuente Graciani Ignacio , Gómez García Lara M. 
Published: August 2020

Resumen

Objetivos
Resaltar el papel del laboratorio clínico y la pronta comunicación con el servicio de Hematología en el diagnóstico y la rapidez en la instauración del tratamiento de una patología hematológica tan urgente como la Púrpura Trombótica Trombocitopénica (PTT).

Caso clínico
Varón de edad avanzada derivado a Urgencias hospitalarias por su médico de Atención Primaria por trastorno de emisión del lenguaje, asimetría facial y disminución de fuerza en extremidad superior, por lo que se activa el código ictus. Sin embargo, los hallazgos de laboratorio (anemia y trombocitopenia, creatinina, bilirrubina total y LDH elevadas, test de Coombs directo negativo) y presencia de esquistocitos en el frotis de sangre periférica, acaban derivando en un diagnóstico completamente diferente: microangiopatía trombótica tipo PTT.

Conclusiones
La primera orientación diagnóstica de ictus hemisférico izquierdo fue rechazada ante los signos de anemia hemolítica no autoinmune, trombocitopenia sin causa aparente y presencia de esquistocitos. No debemos olvidar que esta patología puede cursar con afectación multiorgánica y características clínicas muy variables. Aunque su diagnóstico definitivo se basa en la determinación de actividad de ADAMTS-13, debido a la elevada mortalidad es necesario instaurar tratamiento de forma inmediata tras su sospecha.
Multiplicity of Positive Solutions for a Quasilinear Schrödinger Equation with an Almost Critical Nonlinearity
Authors: Figueiredo Giovany M. , Severo Uberlandio B. , Siciliano Gaetano 
Published: August 2020

Abstract
In this paper we prove an existence result of multiple positive solutions for the following quasilinear problem:

{

-

Δ
⁢
u

-

Δ
⁢

(

u
2

)

⁢
u

=

|
u
|

p
-
2

⁢
u

in
⁢
Ω

,

u

=
0

on
⁢

∂
⁡
Ω

,

\left\{\begin{aligned} \displaystyle-\Delta u-\Delta(u^{2})u&\displaystyle=|u|% ^{p-2}u&&\displaystyle\phantom{}\text{in }\Omega,\\ \displaystyle u&\displaystyle=0&&\displaystyle\phantom{}\text{on }\partial% \Omega,\end{aligned}\right.

where Ω is a smooth and bounded domain in

ℝ
N

,
N

≥
3

{\mathbb{R}^{N},N\geq 3}

. More specifically we prove that, for p near the critical exponent

22
*

=

4
⁢
N

/

(

N
-
2

)

{22^{*}=4N/(N-2)}

, the number of positive solutions is estimated below by topological invariants of the domain Ω: the Ljusternick–Schnirelmann category and the Poincaré polynomial. With respect to the case involving semilinear equations, many difficulties appear here and the classical procedure does not apply immediately. We obtain also en passant some new results concerning the critical case.
On the Observational Implications of Knightian Uncertainty
Authors: Hassett Kevin A. , Zhong Weifeng 
Published: August 2020

Abstract
We develop a model of a prediction market with ambiguity and derive testable implications of the presence of Knightian uncertainty. Our model can also explain two commonly observed empirical regularities in betting markets: the tendency for longshots to win less often than odds would indicate and the tendency for favorites to win more often. Using historical data from Intrade, we further present empirical evidence that is consistent with the predicted presence of Knightian uncertainty. Our evidence also suggests that, even with information acquisition, the Knightian uncertainty of the world may be not “learnable” to the traders in prediction markets.
Community-building without a Building: Can Libraries Resume Their Place as the Academic Hearts of their Campuses?
Authors: Warren Scott 
Published: August 2020

Abstract
As academic libraries begin planning to resume on-site services in fall 2020, the effects of COVID-19 will continue to be felt. Trends such as the longstanding shift to primarily online collections will accelerate. Though budget reductions are widely expected, the need for libraries to keep investing in digital infrastructures that enable open distribution of locally held content will be greater than ever, given much of this content, particularly rare and archival collections, became unavailable during quarantine. Libraries will also need to grapple with the impact of social distancing and building restrictions on their identities as the academic heart of their campuses. This reflects the ways in which library spaces have become increasingly busy and essential by providing student services and community building.
Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain
Authors: Wang Kun , Mao Wei , Zhang Xiaoyu , Zhao Yufei , Fan Kuikui , Pan Deng , Liu Haodong , Li Penghui , Hai Rihan , Du Chenguang 
Published: August 2020

AbstractObjectiveMelanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN), little is known about their distribution throughout the mouse brain, although its messenger RNA distribution has been analyzed in the rat. Therefore, MC4R protein localization in mouse neurons was the focus of this study.MethodsMC4R protein distribution was assessed in mice through immunofluorescence and Western blotting.ResultsMC4R was differentially expressed throughout the arcuate nucleus (ARC), nucleus of the solitary tract (NTS), raphe pallidus (RPa), medial cerebellar nucleus, intermediolateral nucleus, and brainstem. The highest MC4R protein levels were found in the ARC and ventromedial hypothalamic nucleus, while they were significantly lower in the parabrachial nucleus and NTS. The lowest MC4R protein levels were found in the PVN; there was no difference in the protein levels between the area postrema and RPa.ConclusionsThese data provide a basic characterization of MC4R-expressing neurons and protein distribution in the mouse brain and may aid further research on its role in energy homeostasis.
Development and multicenter performance evaluation of fully automated SARS-CoV-2 IgM and IgG immunoassays
Authors: Qian Chungen , Zhou Mi , Cheng Fangming , Lin Xiaotao , Gong Yijun , Xie Xiaobing , Li Ping , Li Zhiyong , Zhang Pingan , Liu Zejin , Hu Fang , Wang Yun , Li Quan , Zhu Yan , Duan Guikai , Xing Yinting , Song Huanyu , Xu Wenfang , Liu Bi-Feng , Xia Fuzhen 
Published: August 2020

Abstract

Objectives
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally. The laboratory diagnosis of SARS-CoV-2 infection has relied on nucleic acid testing; however, it has some limitations, such as low throughput and high rates of false negatives. Tests of higher sensitivity are needed to effectively identify infected patients.

Methods
This study has developed fully automated chemiluminescent immunoassays to determine IgM and IgG antibodies to SARS-CoV-2 in human serum. The assay performance has been evaluated at 10 hospitals. Clinical specificity was evaluated by measuring 972 hospitalized patients and 586 donors of a normal population. Clinical sensitivity was assessed on 513 confirmed cases of SARS-CoV-2 by RT-PCR.

Results
The assays demonstrated satisfied assay precision with coefficient of variation of less than 4.45%. Inactivation of specimen did not affect assay measurement. SARS-CoV-2 IgM showed clinical specificity of 97.33 and 99.49% for hospitalized patients and the normal population respectively, and SARS-CoV-2 IgG showed clinical specificity of 97.43 and 99.15% respectively. SARS-CoV-2 IgM showed clinical sensitivity of 82.54, 92.93, and 84.62% before 7 days, 7–14 days, and after 14 days respectively, since onset of symptoms, and SARS-CoV-2 IgG showed clinical sensitivity of 80.95, 97.98, and 99.15% respectively at the same time points above.

Conclusions
We have developed fully automated immunoassays for detecting SARS-CoV-2 IgM and IgG antibodies in human serum. The assays demonstrated high clinical specificity and sensitivity, and add great value to nucleic acid testing in fighting against the global pandemic of the SARS-CoV-2 infection.
Feasibility for aggregation of commutable external quality assessment results to evaluate metrological traceability and agreement among results
Authors: van der Hagen Eline A. E. , Weykamp Cas , Sandberg Sverre , Stavelin Anne V. , MacKenzie Finlay , Miller W. Greg 
Published: August 2020

Abstract

Objectives
External quality assessment (EQA) with commutable samples is used for assessing agreement of results for patients’ samples. We investigated the feasibility to aggregate results from four different EQA schemes to determine the bias between different measurement procedures and a reference target value.

Methods
We aggregated EQA results for creatinine from programs that used commutable EQA material by calculating the relative difference between individual participant results and the reference target value for each sample. The means and standard errors of the means were calculated for the relative differences. Results were partitioned by methods, manufacturers and instrument platforms to evaluate the biases for the measurement procedures.

Results
Data aggregated for enzymatic methods had biases that varied from −8.2 to 3.8% among seven instrument platforms for creatinine at normal concentrations (61–85 μmol/L). EQA schemes differed in the evidence provided about the commutability of their samples, and in the amount of detail collected from participants regarding the measurement procedures which limited the ability to sub-divide aggregated data by instrument platforms and models.

Conclusions
EQA data could be aggregated from four different programs using different commutable samples to determine bias among different measurement procedures. Criteria for commutability for EQA samples as well as standardization of reporting the measurement methods, reagents, instrument platforms and models used by participants are needed to improve the ability to aggregate the results for optimal assessment of performance of measurement procedures. Aggregating data from a larger number of EQA schemes is feasible to assess trueness on a global scale.
Diabetes mellitus type 2: Exploratory data analysis based on clinical reading
Authors: Nedyalkova Miroslava , Madurga Sergio , Ballabio Davide , Robeva Ralitsa , Romanova Julia , Kichev Ilia , Elenkova Atanaska , Simeonov Vasil 
Published: August 2020

AbstractDiabetes mellitus type 2 (DMT2) is a severe and complex health problem. It is the most common type of diabetes. DMT2 is a chronic metabolic disorder that affects the way your body metabolizes sugar. With DMT2, your body either resists the effects of insulin or does not produce sufficient insulin to continue normal glucose levels. DMT2 is a disease that requires a multifactorial approach of controlling that includes lifestyle change and pharmacotherapy. Less than ideal management increases the risk of developing complications and comorbidities such as cardiovascular disease and numerous social and economic penalties. That is why the studies dedicated to the pathophysiological mechanisms and the treatment of DMT2 are extremely numerous and diverse. In this study, exploratory data analysis approaches are applied for the treatment of clinical and anthropometric readings of patients with DMT2. Since multivariate statistics is a well-known method for classification, modeling and interpretation of large collections of data, the major aim of the present study was to reveal latent relations between the objects of the investigation (group of patients and control group) and the variables describing the objects (clinical and anthropometric parameters). In the proposed method by the application of hierarchical cluster analysis and principal component analysis it is possible to identify reduced number of parameters which appear to be the most significant discriminant parameters to distinguish between four patterns of patients with DMT2. However, there is still lack of multivariate statistical studies using DMT2 data sets to assess different aspects of the problem like optimal rapid monitoring of the patients or specific separation of patients into patterns of similarity related to their health status which could be of help in preparation of data bases for DMT2 patients. The outcome from the study could be of custom for the selection of significant tests for rapid monitoring of patients and more detailed approach to the health status of DMT2 patients.
Optimization-based Attitude Determination in Geodetic Applications
Authors: Pesterev Alexander , Matrosov Ivan , Morozov Yury 
Published: August 2020

AbstractA new approach to determining the attitude of a rigid body is suggested, which does not rely on the use of magnetometers. In the framework of this approach, the problem of determining the attitude reduces to solving a minimization problem for a function of three variables (angles characterizing the initial attitude of the body). The proposed method can be employed in precise geodetic measurements carried out with the use of a geodetic pole with a satellite antenna and an IMU installed on its top when, for some reasons, the surveyor cannot position the pole vertically (e.g., near walls or buildings). The use of the traditional approach, which relies on a compass and accelerometers, in this case does not ensure the desired accuracy of the attitude determination due to magnetic disturbances (both external ones and those induced by the receiver) affecting badly compass readings. The discussion is illustrated by results of field experiments.
Subgroups of direct products of groups invariant under the action of permutations on factors
Authors: Burov Dmitry A. 
Published: August 2020

AbstractWe study subgroups of the direct product of two groups invariant under the action of permutations on factors. An invariance criterion for the subdirect product of two groups under the action of permutations on factors is put forward. Under certain additional constraints on permutations, we describe the subgroups of the direct product of a finite number of groups that are invariant under the action of permutations on factors. We describe the subgroups of the additive group of vector space over a finite field of characteristic 2 which are invariant under the coordinatewise action of inversion permutation of nonzero elements of the field.
Pain pharmacogenetics
Authors: Slepukhina Mariia A. , Ivashchenko Dmitriy V. , Sheina Maria A. , Muradian Andranik Alexandrovich , Blagovestnov Dmitriy Alexeevich , Sychev Dmitriy A. 
Published: August 2020

Abstract
Pain is a significant problem in medicine. The use of PGx markers to personalize postoperative analgesia can increase its effectiveness and avoid undesirable reactions. This article describes the mechanisms of nociception and antinociception and shows the pathophysiological mechanisms of pain in the human body. The main subject of this article is pharmacogenetic approach to the selection of anesthetics. Current review presents data for local and general anesthetics, opioids, and non-steroidal anti-inflammatory drugs. None of the anesthetics currently has clinical guidelines for pharmacogenetic testing. This literature review summarizes the results of original research available, to date, and draws attention to this area.
Sulfonated poly(arylene ether sulfone) functionalized polysilsesquioxane hybrid membranes with enhanced proton conductivity
Authors: Mukherjee Rajdeep , Mandal Arun Kumar , Banerjee Susanta 
Published: August 2020

Abstract
Sulfopropylated polysilsesquioxane and –COOH containing fluorinated sulfonated poly(arylene ether sulfone) composite membranes (SPAES-SS-X) have been prepared via an in situ sol–gel reaction through the solution casting technique. The composite membranes showed excellent thermal and chemical stability, compared to the pristine SPAES membrane. The uniform dispersion of the sulfonated SiOPS nanoparticles on the polymer matrix was observed from the scanning electron microscope images. Atomic force microscopy and transmission electron microscopy images indicated significantly better phase-separated morphology and connectivity of the ionic domains of the composite membranes than the pristine SPAES membrane. The composite membranes showed considerable improvement in proton conductivity and oxidative stability than the pristine copolymer membrane under similar test conditions.
Homburg’s Lockdown Analysis: Conclusions without Data and an Appropriate Estimation Model
Authors: Robra Bernt-Peter , Felder Stefan 
Published: August 2020

Abstract
This is a critical response to Homburg (2020) who claimed that lockdowns were superfluous and ineffective. We demonstrate that Homburg’s database is not sufficient to support his claim and that his econometric approach not suitable for an analysis of the lockdowns’ additional effect. However, we corroborate Homburg’s observation that the number of infections was already receding when the German lockdown came into force.
On some higher order equations admitting meromorphic solutions in a given domain
Authors: Barsegian Grigor , Meng Fanning 
Published: August 2020

Abstract
This paper relates to a recent trend in complex differential equations which
studies solutions in a given domain.
The classical settings in complex equations were widely studied for meromorphic solutions in the complex plane.
For functions in the complex plane, we have a lot of results of general nature, in particular, the classical value distributions theory describing numbers of a-points.
Many of these results do not work for functions in a given domain.
A recent principle of derivatives permits us to study the numbers of Ahlfors simple islands for functions in a given domain;
the islands play, to some extend, a role similar to that of the numbers of simple a-points.
In this paper, we consider a large class of higher order differential equations admitting meromorphic solutions in a given domain.
Applying the principle of derivatives, we get the upper bounds for the numbers of Ahlfors simple islands of similar solutions.
Self-esteem and social esteem: Is Adam Smith right?
Authors: Brennan Geoffrey 
Published: August 2020

Abstract
In Part III of The Theory of Moral Sentiments, Adam Smith declares that people desire to be both esteemed and to be esteem-worthy, but that the latter desire both does and ought to take priority. The main object of this paper is to challenge that priority claim—mainly in its descriptive aspect. If that claim were true, then: agents would be at pains to eliminate any distortions in their self-evaluations; and the effects of the size (especially of total secrecy) and the character of audience on behaviour would be second-order. Empirical evidence suggests otherwise. Moreover the normative claim seems to overlook some advantages of inflated self-evaluation; and to allow no independent room for norms of modesty/humility.
Epistemic self-esteem of philosophers in the face of philosophical disagreement
Authors: Bernáth László , Tőzsér János 
Published: August 2020

Abstract
Our paper consists of four parts. In the first part, we describe the challenge of the pervasive and permanent philosophical disagreement over philosophers’ epistemic self-esteem. In the second part, we investigate the attitude of philosophers who have high epistemic self-esteem even in the face of philosophical disagreement and who believe they have well-grounded philosophical knowledge. In the third section, we focus on the attitude of philosophers who maintain a moderate level of epistemic self-esteem because they do not attribute substantive philosophical knowledge to themselves but still believe that they have epistemic right to defend substantive philosophical beliefs. In the fourth section, we analyse the attitude of philosophers who have a low level of epistemic self-esteem in relation to substantive philosophical beliefs and make no attempt to defend those beliefs. We argue that when faced with philosophical disagreement philosophers either have to deny that the dissenting philosophers are their epistemic peers or have to admit that doing philosophy is less meaningful than it seemed before. In this second case, philosophical activity and performance should not contribute to the philosophers’ overall epistemic self-esteem to any significant extent.
Investigating the Relationship Between Emotion Recognition Software and Usability Metrics
Authors: Schmidt Thomas , Schlindwein Miriam , Lichtner Katharina , Wolff Christian 
Published: August 2020

AbstractDue to progress in affective computing, various forms of general purpose sentiment/emotion recognition software have become available. However, the application of such tools in usability engineering (UE) for measuring the emotional state of participants is rarely employed. We investigate if the application of sentiment/emotion recognition software is beneficial for gathering objective and intuitive data that can predict usability similar to traditional usability metrics. We present the results of a UE project examining this question for the three modalities text, speech and face. We perform a large scale usability test (N = 125) with a counterbalanced within-subject design with two websites of varying usability. We have identified a weak but significant correlation between text-based sentiment analysis on the text acquired via thinking aloud and SUS scores as well as a weak positive correlation between the proportion of neutrality in users’ voice and SUS scores. However, for the majority of the output of emotion recognition software, we could not find any significant results. Emotion metrics could not be used to successfully differentiate between two websites of varying usability. Regression models, either unimodal or multimodal could not predict usability metrics. We discuss reasons for these results and how to continue research with more sophisticated methods.
How Can I Grab That?
Authors: Weise Matthias , Zender Raphael , Lucke Ulrike 
Published: August 2020

Abstract
The selection and manipulation of objects in Virtual Reality face application developers with a substantial challenge as they need to ensure a seamless interaction in three-dimensional space. Assessing the advantages and disadvantages of selection and manipulation techniques in specific scenarios and regarding usability and user experience is a mandatory task to find suitable forms of interaction. In this article, we take a look at the most common issues arising in the interaction with objects in VR. We present a taxonomy allowing the classification of techniques regarding multiple dimensions. The issues are then associated with these dimensions. Furthermore, we analyze the results of a study comparing multiple selection techniques and present a tool allowing developers of VR applications to search for appropriate selection and manipulation techniques and to get scenario dependent suggestions based on the data of the executed study.