bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acacia seed proteins: Low or high quality? A comprehensive review
Authors: Adiamo Oladipupo Q. , Netzel Michael E. , Hoffman Louwrens C. , Sultanbawa Yasmina 
Published: December 2019

AbstractThe popularity of adding value to indigenous plant protein sources has increased due to the rise in the world population, high costs of animal protein as compared to plant proteins, and an increase in the consumer awareness of the nutritional and functional roles of dietary plant protein. Seeds of acacia plants (containing over 1,350 species) have considerable amount of protein (18.25% to 35.5%) and nutritionists have shown great interest in assessing the quality and functionality of proteins from these protein‐rich plants. In this review, the overall nutritional and health‐promoting properties of acacia seed (AS) species are introduced. Extraction, quality, and functional properties of proteins from different AS species are discussed. Furthermore, anti‐nutritional components and protease inhibitors present in AS species and the effects of processing methods applied to lower the levels of anti‐nutrients are also discussed. Previous applications of AS in food formulations are highlighted. This review aims to provide updated findings that have been reported on AS proteins and to highlight areas for further studies in order to increase the utilization potential of the seeds.
Transfusion errors — can they be eliminated?
Authors: Bolton‐Maggs Paula H. B. , Watt Alison 
Published: December 2019

SummaryThe Serious Hazards of Transfusion haemovigilance scheme has documented adverse transfusion incidents for 22 years. Transmission of infection (three in 2018), transfusion‐related lung injury (one in 2018) and transfusion‐associated graft‐versus‐host disease (none since 2012) are rare. Despite national recommendations, guidelines and protocols, most incidents more than 85% of incidents are still due to errors in the transfusion process. European regulation and mandatory competency assessments have been associated with a reduction in ABO‐incompatible transfusion, but errors continue to put patients at risk. What can be done? Errors are reduced by the use of electronic identification systems. Exploration of human factors and ergonomics (HFE) results in amended approaches away from blaming individuals to a full review of the systems and environment. Research examining how transfusion is performed (work‐as‐done) compared to work‐as‐imagined (set out in protocols and guidelines) discovers where variability results in either resilience or error. All staff require HFE training, but this should be alongside employment of suitably qualified and experienced HFE professionals. Good teamwork is key and is undermined by insufficient staffing and poor morale. The five choosing wisely recommendations for transfusion (to ensure appropriate use) need to be widely disseminated to medical staff in all specialties to ensure patients participate in the decision‐making.
Insects and light interact to mediate vine colonization of fast growing Microberlinia bisulcata tree seedlings in gaps of an African rain forest
Authors: Norghauer Julian M. 
Published: December 2019

AbstractVines thrive in lowland tropical forests, yet the biotic factors underlying their colonization of host tree seedlings and saplings remain surprisingly understudied. Insect herbivores presumably could influence this process, especially where disturbance has opened the canopy (i.e., gaps)—temporary areas of higher primary productivity favoring the recruitment of vines and trees and invertebrates in forests—but their impact on vine colonization has never been experimentally tested. Using data from an insect herbivore exclusion (mesh‐netting cages) experiment conducted in an African rain forest (Korup, Cameroon), I logistically modeled the probability of vines colonizing seedlings of three co‐dominant species (Microberlinia bisulcata vs. Tetraberlinia bifoliolata and T. korupensis) in paired shaded understory and sunny gap locations (41 blocks across 80 ha, starting n = 664 seedlings) in a 1–2‐yr period (2008–2009). Vine colonization occurred almost exclusively in gaps, occurring on 16% of seedlings there. Excluding herbivores in gaps doubled colonization of the light‐demanding and faster growing M. bisulcata but had negligible effects on the two shade‐tolerant, slower growing and less palatable Tetraberlinia species, which together were twice as susceptible to vines under natural forest gap conditions (controls). When protected from herbivores in gaps, more light to individual seedlings strongly increased vine colonization of M. bisulcata whereas its well‐lit control individuals supported significantly fewer vines. These results suggest vines preferably colonize taller seedlings, and because light‐demanding tree species grow faster in height with more light, they are more prone to being colonized in gaps; however, insect herbivores can mediate this process by stunting fast growing individuals so that colonization rates becomes more similar between co‐occurring slow and fast growing tree species. Further influencing this process might be associational resistance or susceptibility to herbivores linked to host species’ leaf traits conferring shade‐tolerant ability as seedlings or saplings. A richer understanding of how vines differentially influence forest regeneration and species composition may come from investigating vine–tree–herbivore interactions across light gradients, ideally via long‐term studies and intercontinental comparisons.Abstract in French is available with online material.
The rise of supplemental lending at the World Bank
Authors: Kersting Erasmus , Kilby Christopher 
Published: December 2019

AbstractWorld Bank projects sometimes receive supplemental loans months or years after initial project approval. Largely unnoticed, supplemental lending has mushroomed in the last decade, accounting for nearly 30% of all new loans in some years. These loans can serve important functions, as they come without the bureaucratic delays associated with new projects. We argue that supplemental loans are potentially useful foreign policy tools for powerful donors in settings where time is of the essence. Consistent with this, we find that countries receive significantly larger supplemental loans while serving a two‐year term on the geopolitically important United Nations Security Council.
Understanding parental concerns related to their child's development and factors influencing their decisions to seek help from health care professionals: Results of a qualitative study
Authors: Camden Chantal , Dostie Rosalie , Heguy Lea , Gauvin Cheyenne , Hudon Catherine , Rivard Lisa , Gaboury Isabelle 
Published: December 2019

AbstractBackgroundEarly identification of children at risk of developmental delay is crucial to promote healthy development. Assessing parental concerns about development is often part of identification processes. However, we currently do not understand well how and why parents become concerned and how and why they access early identification and intervention services. The purpose of this study was to explore parental perceptions about their child's development and the factors influencing their reported professional help‐seeking behaviours.MethodsThis exploratory study was part of a larger study describing child development in children aged 2–5 in a small Canadian city. We conducted semistructured interviews with 16 parents whose children were at risk of developmental delay to examine their perceptions of their child's development, their use of community services promoting development, and their recommendations to optimize those services.ResultsFour themes were identified: (a) Vision of child development influencing help‐seeking behaviours: Natural or Supported?, (b) Internal and external sources contributing to parents' level of developmental concern, (c) Using internal resources and struggling to access external resources, and (d) Satisfaction with services accessed and recommendations to access more support. Parents' vision of child development along with sources of parental concern appeared to influence the level of concern, enhancing our understanding of how parents become concerned. The level of concern and parents' knowledge and perceived access to resources seemed to influence their decision whether or not to consult health care professionals. Parents provided many suggestions to improve services to promote child development and support families.DiscussionResults highlight the importance of supporting parents in recognizing if their child is at risk of delay and increasing awareness of available resources. It appears particularly important to ensure that health care professionals and community‐based support services are accessible to provide parents with the support they need, especially when they have concerns.
A case report of right atrial epithelioid hemangioendothelioma with multiple pulmonary metastases
Authors: Zhou Xiaoming , Li Peng , Gu Xiu , Zheng Fushuang , Zhao Jungang , Zhao Li 
Published: December 2019

AbstractCardiac epithelioid hemangioendothelioma (EHE) is a very rare tumour of endothelial origin with the lung and liver as the most easily metastatic organs. We describe herein a patient with hemoptysis, severe anaemia, and diffuse pulmonary nodules with halo signs that represented metastasis of cardiac EHE; these radiologic manifestations are relatively uncommon. During the initial workup for the patient’s pulmonary nodules, echocardiography missed the cardiac mass. However, positron emission tomography‐computed tomography revealed increased fluorodeoxyglucose intake in the right atrial wall, and cardiac magnetic resonance imaging (MRI) revealed an irregular nodule with normal T1‐weighted signal intensity and hyperintense T2‐weighted signal intensity. Enhanced abdominal computed tomography (CT) revealed micronodular liver metastases. Video‐assisted thoracic surgery was performed to make a definitive diagnosis. Immunohistochemistry staining proved the diagnosis of EHE with positive results for cluster of differentiation (CD) 34, CD31, erythroblast transformation‐specific‐related gene and Ki‐67. The patient started chemotherapy with docetaxel (75 mg/m2) and gemcitabine (900 mg/m2), but this failed to control his disease and he died from an opportunistic infection related to his immunocompromised status 5 months later. For the work out process of bilateral diffuse pulmonary nodules suspicious for cardiac origin, especially with atrial deviation, echocardiography alone is not sufficient to exclude atrial origin. Cardiac CT or MRI might be a better choice.
Developmental duration as an organizer of the evolving mammalian brain: scaling, adaptations, and exceptions
Authors: Finlay Barbara L. , Huang Kexin 
Published: December 2019

AbstractNeurodevelopmental duration plays a central role in the evolution of the retina and neocortex in mammals. In the diurnal primate eye and retina, it is necessary to scale the number of cones versus the number of rods with different exponents to defend their respective functions of spatial acuity and sensitivity in eyes of different sizes. The order of photoreceptor precursor specification, cones specified first, rods second, couples their respective cell numbers at maturity to the kinetics of embryonic stem cell proliferation. Different durations of retinogenesis change the ratio of rods to cones produced so as to defend both functions over a range of eye diameters. In the evolution of nocturnality, the same coupling of photoreceptor specification to neurogenesis is altered to fewer cones and many more rods in nocturnal eyes, by delaying the onset of retinogenesis. Similarly, the neocortex also shows coupling of the specification of laminar position with duration of neurogenesis. Overall, duration of neurogenesis directly predicts neocortex volume in most mammalian clades. In larger brains with longer neocortical neurogenesis, its organization changes progressively, differentiating the frontal pole from the occipital pole in volume of connectivity and number of neurons per unit column. This permits greater, hierarchically organized information abstraction with increasing neocortex volume. Exceptions do exist, however, in species of three separate taxa, marsupials, naked mole rats, and bats, which break the correlation of neurodevelopmental duration and brain size. Naked mole rats and bats both have small brains and unusual longevity, coupled with neurodevelopmental periods characteristic of much bigger‐brained animals, raising the possibility that developmental duration and lifespan have some genetic or mechanistic control in common. The role of duration of development in mediating between the mechanistic levels of construction of retinal and cortical organization, and the different life histories associated with larger brains, such as duration of parental care, learning and overall longevity are discussed.
Autistic traits modulate cortical responses to affective but not discriminative touch
Authors: Haggarty Connor J. , Malinowski Peter , McGlone Francis P. , Walker Susannah C. 
Published: December 2019

AbstractThe sense of touch is primarily considered a discriminative and exteroceptive sense, facilitating the detection, manipulation and exploration of objects, via an array of low‐threshold mechanoreceptors and fast conducting A‐beta (Aβ) afferents. However, a class of unmyelinated, low‐threshold mechanoreceptors identified in the hairy skin of mammals have been proposed to constitute a second, anatomically distinct system coding the affective qualities of touch. Unlike Aβs, which increase their firing rate linearly with the velocity of a stimulus moving across their receptive field, the response of these C‐tactile afferents (CTs) is described by an inverted ‘U’ curve fit, responding optimally to a skin temperature stimulus moving at between 1 and 10 cm/s. Given the distinct velocity tuning of these fast and slow touch fibres, here we used event‐related potentials to compare the time course of neural responses to 1st (fast) and 2nd (slow) touch systems. We identified a higher amplitude P300 in response to fast, Aβ‐targeted, versus slow CT‐targeted, stroking touch. In contrast, we identified a previously described, C‐fibre specific, ultra‐late potential (ULP) associated with CT‐targeted input. Of special note as regards the function of CTs is that the amplitude of the ULP was negatively correlated with self‐reported levels of autistic traits, which is consistent with the hypothesized affective and social significance of this response. Taken together, these findings provide further support for distinct discriminative and affective touch systems and suggests the temporal resolution of EEG provides an as yet underutilized tool for exploring individual differences in response sensitivity to CT‐targeted touch.
Prospective validation study of an epilepsy seizure risk system for outpatient evaluation
Authors: Chiang Sharon , Goldenholz Daniel M. , Moss Robert , Rao Vikram R. , Haneef Zulfi , Theodore William H. , Kleen Jonathan K. , Gavvala Jay , Vannucci Marina , Stern John M. 
Published: December 2019

AbstractObjectiveWe conducted clinical testing of an automated Bayesian machine learning algorithm (Epilepsy Seizure Assessment Tool [EpiSAT]) for outpatient seizure risk assessment using seizure counting data, and validated performance against specialized epilepsy clinician experts.MethodsWe conducted a prospective longitudinal study of EpiSAT performance against 24 specialized clinician experts at three tertiary referral epilepsy centers in the United States. Accuracy, interrater reliability, and intra‐rater reliability of EpiSAT for correctly identifying changes in seizure risk (improvements, worsening, or no change) were evaluated using 120 seizures from four synthetic seizure diaries (seizure risk known) and 120 seizures from four real seizure diaries (seizure risk unknown). The proportion of observed agreement between EpiSAT and clinicians was evaluated to assess compatibility of EpiSAT with clinical decision patterns by epilepsy experts.ResultsEpiSAT exhibited substantial observed agreement (75.4%) with clinicians for assessing seizure risk. The mean accuracy of epilepsy providers for correctly assessing seizure risk was 74.7%. EpiSAT accurately identified seizure risk in 87.5% of seizure diary entries, corresponding to a significant improvement of 17.4% (P = .002). Clinicians exhibited low‐to‐moderate interrater reliability for seizure risk assessment (Krippendorff's α = 0.46) with good intrarater reliability across a 4‐ to 12‐week evaluation period (Scott's π = 0.89).SignificanceThese results validate the ability of EpiSAT to yield objective clinical recommendations on seizure risk which follow decision patterns similar to those from specialized epilepsy providers, but with improved accuracy and reproducibility. This algorithm may serve as a useful clinical decision support system for quantitative analysis of clinical seizure frequency in clinical epilepsy practice.
Evaluation of histamine‐provoked changes in airflow using electrical impedance tomography in horses
Authors: Secombe Cristy , Waldmann Andreas D. , Hosgood Giselle , Mosing Martina 
Published: December 2019

AbstractBackgroundElectrical impedance tomography (EIT) generates thoracic impedance images of the lungs and has been used to assess ventilation in horses. This technique may have application in the detection of changes in airflow associated with equine asthma.ObjectivesThe objective was to determine if histamine‐induced airflow changes observed with flowmetric plethysmography (Δflow) could also be explained using global and regional respiratory gas flow signals calculated from EIT signals.Study designExperimental in vivo study.MethodsSix horses, sedated using detomidine were fitted with a thoracic EIT belt and flowmetric plethysmography hardware. Saline (baseline = BL) and increasing concentrations of histamine (C1‐4) were nebulised into the face mask until a change in breathing pattern was clinically confirmed and Δflow increased greater or equal to 50%. After nebulisation Δflow and EIT images were recorded over 3 minutes and peak global inspiratory (InFglobal) and expiratory (ExFglobal) flow as well as peak regional expiratory and inspiratory flow for the dorsal and the ventral area of the right and left lungs were evaluated. Delta flow, InFglobaland ExFglobalat subsequent concentrations were indexed to baseline (yi = Ci/BL−1). Indexed and nonindexed variables were evaluated for a difference from baseline at sequential histamine doses (time). Multiple linear regression assessment of variance in delta flow was also investigated.ResultsConsistent with histamine‐provoked increases in Δflow, the global flow indices increased significantly. A significant increase in regional inspiratory flow was seen in the right and left ventral lung and dorsal right lung. Multiple regression revealed that the variance in ExFglobal, and right and left ventral expiratory flow best explained the variance in Δflow (r2 = .82).Main limitationsLow number of horses and horses were healthy.ConclusionsStandardised changes in airflow during histamine challenge could be detected using EIT gas flow variables.
Hybrid particle swarm optimization for rule discovery in the diagnosis of coronary artery disease
Authors: Zomorodi‐moghadam Mariam , Abdar Moloud , Davarzani Zohreh , Zhou Xujuan , Pławiak Pawel , Acharya U.Rajendra 
Published: December 2019

AbstractCoronary artery disease (CAD) is one of the major causes of mortality worldwide. Knowledge about risk factors that increase the probability of developing CAD can help to understand the disease better and assist in its treatment. Recently, modern computer‐aided approaches have been used for the prediction and diagnosis of diseases. Swarm intelligence algorithms like particle swarm optimization (PSO) have demonstrated great performance in solving different optimization problems. As rule discovery can be modelled as an optimization problem, it can be mapped to an optimization problem and solved by means of an evolutionary algorithm like PSO. An approach for discovering classification rules of CAD is proposed. The work is based on the real‐world CAD data set and aims at the detection of this disease by producing the accurate and effective rules. The proposed algorithm is a hybrid binary‐real PSO, which includes the combination of categorical and numerical encoding of a particle and a different approach for calculating the velocity of particles. The rules were developed from randomly generated particles, which take random values in the range of each attribute in the rule. Two different feature selection methods based on multi‐objective evolutionary search and PSO were applied on the data set, and the most relevant features were selected by the algorithms. The accuracy of two different rule sets were evaluated. The rule set with 11 features obtained more accurate results than the rule set with 13 features. Our results show that the proposed approach has the ability to produce effective rules with highest accuracy for the detection of CAD.
Cyclization mechanism catalyzed by an ATP‐grasp enzyme essential for d‐cycloserine biosynthesis
Authors: Matoba Yasuyuki , Uda Narutoshi , Kudo Mako , Sugiyama Masanori 
Published: December 2019

In the biosynthetic pathway of an antitubercular antibiotic d‐cycloserine (d‐CS), O‐ureido‐d‐serine (d‐OUS) is converted to d‐CS. We have previously demonstrated that DcsG, classified into the ATP‐grasp superfamily enzyme, catalyzes the ring formation to generate d‐CS, which is accompanied by the cleavage of a bond in the urea moiety of d‐OUS to remove a carbamoyl group. Although the general ATP‐grasp enzymes catalyze an ATP‐dependent ligation reaction between two substrates, DcsG catalyzes specifically the generation of an intramolecular covalent bond. In the present study, cyanate was found in the reaction mixture, suggesting that carbamoyl group is eliminated as an isocyanic acid during the reaction. By the crystallographic and mutational investigations of DcsG, we anticipate the residues necessary for the binding of d‐OUS. An acylphosphate intermediate must be bound at the narrow pocket of DcsG in a folded conformation, inducing the bond cleavage and the new bond formation to generate cyanate and d‐CS, respectively.DatabaseStructural data are available in Protein Data Bank database under the accession number 6JIL.
Loading‐rate dependence of mode I crack growth in concrete
Authors: Ma Minhua , Wu Zhimin , Hu Xiaozhi , Yu Rena C. , Fei Xiaodong 
Published: December 2019

AbstractMode I crack propagation process of concrete under relatively low loading rates which cover four orders of magnitude (0.2 μm/s to 2.0 mm/s) is investigated with three‐point bending (TPB) beams. All measured material properties exhibit rate sensitivity and follow a log‐linear relationship with the loading rate. A rate‐sensitive softening curve is established. The complete load‐crack mouth opening displacement (P‐CMOD) curve, crack propagation length, and fracture process zone (FPZ) length are simulated based on crack growth criterion with the fitted material parameters under those loading rates. Results show that the simulated P‐CMOD curves agree well with those of experimental measurements. It is clear that the peak load increases with the loading rate and so is the critical crack mouth opening displacement. Moreover, under the same load level, the length of the FPZ and the cohesive stress at the initial crack tip also increase with the increasing loading rate.