bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents
Authors: Tang Yan-Ling , Li Yong-Kun , Li Min-Xin , Gao Hui , Yang Xiao-Bi , Mao Ze-Wei 
Published: December 2019

Background:
Infection is a global threat to human health, and there is an urgent need to develop
new effective antibacterial drugs to treat bacterial infections.

Objective:
To study the antibacterial activity of piperazine substituted chalcone sulphonamides.

Materials and Methods:
A series of novel piperazine substituted chalcone sulphonamides have been prepared,
and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains
were evaluated.

Results:
The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against
Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.

Conclusion:
Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.
Food Services Menu Engineering: Preference, Acceptability, and Popularity Index of Local Food Package Menus to Control the Glycemic Responses of T2DM Subjects
Authors: Hakimah Nurul , Rahman Nur , Sucipto Sucipto , Wignyanto Wignyanto , Aulanni'am Aulanni'am 
Published: December 2019

Background:
The purpose of this study was to analyze the menu engineering data:
preferences, acceptances, and popularity indexes of local food package menus with low to moderate
glycemic index and how these variables affect the glycemic response of subjects with type 2 diabetes
mellitus (T2DM).

Methods:
This study was a one group pre and post-test experimental study with 21 T2DM
participants. A total of 1,764 menu engineering data were obtained during the two-week study
period. Fifteen food service survey questions were distributed and anthropometric and glycemic
responses were measured.

Results:
The popularity indexes of the main and snack package menus were significantly different
(p=0,000). There was a significant decrease (p<0.05) in Δ RBG levels by 59.6±115.8 mg/ dL
(26.7%) and Δ % albumin glycated by 1.5±1.0 (6.1%) (p = 0.000) on 38% subjects with good
glycemic control who consumed less food outside the study (12.5%). Price, type of food, type of
foodstuff, nutrient content, portion size, food appearance, food texture, GI values, food menu name,
and menu conformity to the environment were important considerations in the menu preference and
popularity.

Conclusion:
This study showed that the local food package menu can control the glycemic response
of T2DM participants while having a high popularity index. This finding provides an opportunity for
the foodservice industry to operate sustainably by considering the factors desired by consumers with
T2DM in controlling their long-term glycemic response.
Pro- and Anti-Inflammatory Cytokine Expression Levels in Macrophages; An Approach to Develop Indazolpyridin-methanones as Novel Inflammation Medication
Authors: Alagumuthu Manikandan , Srivastava Vanshika , Shah Manisha , Arumugam Sivakumar , Sonaimuthu Mohandoss , Arumugam Napoleon Ayyakannu 
Published: December 2019

Background:
Macrophages play a serious part in the instigation, upkeep, and
resolution of inflammation. They are activated or deactivated during inflammation progression.
Activation signals include cytokines (IF-γ, granulocyte-monocyte colonystimulating
factor (GM-CSF), and TNF-α), extracellular matrix proteins, and other chemical
mediators. Activated macrophages are deactivated by anti-inflammatory cytokines (IL-
10 and TGF-β (transforming growth factor-beta) and cytokine antagonists that are mainly
produced by macrophages. Based on this, the present study aimed to develop novel (E)-
Benzylidene-indazolpyridin methanones (Cpd-1-10) as effective anti-inflammatory agents
by analyzing pro- and anti-inflammatory cytokine levels in macrophages.

Objectives:
To determine the anti-inflammatory effect of indazolpyridin-methanones by
examining pro- and anti-inflammatory interleukin levels in J77A.1 macrophages.

Methods:
Expression of cytokines such as TNF-α, IL-1β, IL-6 and IL-10 serum levels
measured by ELISA method. Anti-cancer and cytotoxicity studies were carried out by
MTT assay. COX-2 seems to be associated with cancers and atypical developments in the
duodenal tract. So, a competitive ELISA based COX-2 inhibition assay was done. To validate
the inhibitory potentials and to get more insight into the interaction of COX-2 with
Cpd1-10, molecular docking was performed.

Results:
Briefly, the COX-2 inhibitory relative activity was found to be in between the
range of 80-92% (Diclofenac showed 84%, IC50 0.95 μM).

Conclusion:
Cytotoxicity effect of the compounds against breast cancer cell lines found
excellent and an extended anticancer study ensured that these compounds are also alternative
therapeutic agents against breast cancer. Among all the tested cancer cell lines, the anti-
cancer effect on breast cancer was exceptional for the most active compounds Cpd5 and
Cpd9.
Role of Subclinical Iatrogenic Hyperthyroidism in the Setting of Heart Disease and Arrhythmic Burden
Authors: Mastroianno Sandra , Di Stolfo Giuseppe , Maggio Angela , Pacilli Michele , Potenza Domenico Rosario , Massaro Raimondo , De Luca Giovanni , Russo Aldo 
Published: December 2019

Background:
Subclinical hyperthyroidism is defined by a subnormal serum thyroidstimulating
hormone (TSH) level with normal free thyroxine (FT4) and free triiodothyronine (FT3)
levels. Its prevalence varies from 0.6% to 16% in the elderly and can increase to 20% in patients receiving
thyroid hormone replacement therapy. Thyroid disease and/or replacement therapy are frequently
associated with cardiovascular involvement.

Cases Presentation:
We report three clinical cases of patients with initial subclinical hyperthyroidism
and cardiological manifestations, including supraventricular and ventricular extrasystoles, prolapse of
the mitral valve with severe regurgitation, higher mean heart rate and deterioration of the arrhythmias
on arrhythmogenic dysplasia substrate.

Conclusion:
We discuss the role of appropriate and early correction of thyroid dysfunction in improving
cardiological manifestations.
Performance Analysis of Cluster-Based DDoS Defense System with Different Reactive Routing Protocols
Authors: Nehra Deepa , Dhindsa Kanwalvir Singh , Bhushan Bharat 
Published: December 2019

Background & Objective:
DDoS attack poses a huge threat to communication and security of mobile nodes in MANETs. The number of approaches proposed to defense against DDoS attacks in MANETs is much less as compared to those for the wire-based networks. The aim of this paper is to test the effectiveness of proposed cluster based DDoS attacks mechanism with various reactive routing protocols.

Method:
The scheme proposed here is clustering based DDoS defense mechanism, in which the Accepted: cluster heads monitors the incoming traffic to identify the presence of suspicious behaviour. After the successful identification of suspicious behavior, the flow responsible behind it will be identified and confirmed whether it is related to DDoS attack or not. Once DDoS attack is confirmed, all the packet related to it will be discarded.

Results & Discussions:
OMNeT++ along with the INET framework is used to evaluate the effectiveness
of the proposed defense scheme with different routing protocols. In attack situations,
DYMO exhibited higher throughput and able to deliver approximately 95% legitimate packets.
DYMO, in comparison to AODV and DSR, managed to control end-to-end delay at its best levels
(i.e. 0.40 to 0.70 seconds). In terms of packet delivery ratio, AODV and DYMO both perform better
than DSR and able to maintain PDR at their highest levels (i.e. 0.90 to 0.94).

Conclusion:
The attack detection mechanism proposed here performs various tasks like monitoring, characterization, and identification of attack traffic from the incoming flow with the help neighbouring cluster heads. The flow identified as attack is discarded and attack related information would be shared with neighbouring cluster heads to achieve distributed defense. The performance of proposed defense system is assessed with different reactive routing protocols and identified that DYMO protocols performs better than AODV and DSR.
Synthesis of Pt-MWCNT Nano Composite in Trioctylmethyl Ammonium Hydrogen Phthalate (TOMAHP) Ionic Liquid Using Ultrasonic Cavitation
Authors: Biswas Sujoy , Dasgupta Kinshuk , Sahu M.L. , Srivastave Amit 
Published: December 2019

Background:Synthesis of nano composite materials is very important topic in recent times for its wide application as a catalyst in various chemical processes. Among various nano composite platinum-mutliwall Carbone Nano Tubes is of particular interest in recent past due to its unique application in methanol fuel cell as a catalyst. Now the challenge is to make a chemical process for definite size and shape selective platinum-mutliwall Carbone Nano Tubes catalyst/composite with well distribution and easy scale up.Methods:The aim of the present work is to develop a chemical process for synthesis of platinum- Mutliwall Carbone Nano Tubes nano catalyst/composite with very low size (1-3nm) using reduction of Pt4+and subsequently deposition to the Mutliwall Carbone Nano Tubes surface using ultrasound technique.Results:The platinum nano materials synthesized in trioctylmethyl ammonium hydrogen phthalate is characterized using TEM technique. The results show that the particle size of platinum nano are in the range of 1-3 nm. The platinum-mutliwall Carbone Nano Tubes catalyst/composite prepared using ultrasound technique does not change the particle size of the platinum nano particles. The distribution of platinum nano on Functionalized Mutliwall Carbone Nano Tubes surface is uniform compared to Non-functionalized Mutliwall Carbone Nano Tubes.Conclusion:The preparation of platinum-mutliwall Carbone Nano Tubes nano composite with very low size of platinum (1-3nm) is achieved in trioctylmethyl ammonium hydrogen phthalate as functionalized ionic liquid in presence of ultrasound.
Analyzing Medical Research Results Based on Synthetic Data and Their Relation to Real Data Results: Systematic Comparison From Five Observational Studies
Authors: Reiner Benaim Anat , Almog Ronit , Gorelik Yuri , Hochberg Irit , Nassar Laila , Mashiach Tanya , Khamaisi Mogher , Lurie Yael , Azzam Zaher S , Khoury Johad , Kurnik Daniel , Beyar Rafael 
Published: December 2019

Background
Privacy restrictions limit access to protected patient-derived health information for research purposes. Consequently, data anonymization is required to allow researchers data access for initial analysis before granting institutional review board approval. A system installed and activated at our institution enables synthetic data generation that mimics data from real electronic medical records, wherein only fictitious patients are listed.

Objective
This paper aimed to validate the results obtained when analyzing synthetic structured data for medical research. A comprehensive validation process concerning meaningful clinical questions and various types of data was conducted to assess the accuracy and precision of statistical estimates derived from synthetic patient data.

Methods
A cross-hospital project was conducted to validate results obtained from synthetic data produced for five contemporary studies on various topics. For each study, results derived from synthetic data were compared with those based on real data. In addition, repeatedly generated synthetic datasets were used to estimate the bias and stability of results obtained from synthetic data.

Results
This study demonstrated that results derived from synthetic data were predictive of results from real data. When the number of patients was large relative to the number of variables used, highly accurate and strongly consistent results were observed between synthetic and real data. For studies based on smaller populations that accounted for confounders and modifiers by multivariate models, predictions were of moderate accuracy, yet clear trends were correctly observed.

Conclusions
The use of synthetic structured data provides a close estimate to real data results and is thus a powerful tool in shaping research hypotheses and accessing estimated analyses, without risking patient privacy. Synthetic data enable broad access to data (eg, for out-of-organization researchers), and rapid, safe, and repeatable analysis of data in hospitals or other health organizations where patient privacy is a primary value.
DNA Extraction of Sumatran Striped Rabbit from Tissue Samples
Authors: Saputra Rio Firman , Setiawan Arum , Yustian Indra , Patriono Enggar 
Published: December 2019

The Sumatran Striped Rabbit (Nesolagus netscheri ) is a naturally rare, which is a protected animal based on Government Regulation Number 7 of 1999 and renewal of Permen LHK No. P.106 which are categorized as Data Deficient by the IUCN (International Union of Conservation of Nature) since 2019. Samples were obtained from Pagar Alam, South Sumatra. Most commonly found at elevations above 600 m in montane and sub-montane primary habitat. Molecular genetic characterization of sumatran striped rabbit is to know genetic information and genetic identification of N. netscheri. Primers 12S rRNA were used in this study to characterize Sumatran striped rabbit. A 1 band were detected ranged from 900 to 1000 bp. Molecular markers represent reliable tools which may have a great impact in rabbit breeding and genetic improvement of rabbits. Molecular markers on Nesolagus netscheri is expected to tools in the identification of Sumatran striped rabbits from South Sumatra.
Typical Expression Of Cognitive Dissonance And Consonance In The Course Of Argumentation Among Primary-School Children Playing Chess
Authors: Mirzakhanyan Ruben K. , Gevorgyan Srbuhi R. , Karapetyan Vladimir S. , Dallakyan A.M. , Berberyan Asya S. 
Published: December 2019

The research aims to reveal the typical expressions of cognitive dissonance and consonance among the primary-school children by their argumentations upon their deed. The relevance of the research stems from the applicability of the study of the phenomena of dissonance and consonance, which inherently emerge in the sphere of argumentation among the children who study how to play chess. Cognitive dissonance and consonance in the sphere of argumentation in the course of the game of chess are gradually transforming both into the respective reference points – relevant to the situation given, and into the emotional and behavioural manifestations – either adequately or inadequately expressed and, by the logical and inner conflict, are observed as the result of juxtaposition of the realms of emotions and logic.
The present research evidences that, in the case of similar chess skills, the manifestation of cognitive dissonance, and the own argumentation as well are detectable within the domain of extroversion – emotional instability. Such children, even more than the introverts, need the school psychologist’s support. The cognitive consonance is typical of those of the children involved who are ready to gain new experience and appear to be more positively charged towards their rivals or opponents.
Szczepienia ochronne u dzieci w trakcie i po leczeniu onkologicznym oraz w wybranych chorobach hematologicznych: rekomendacje Polskiego Towarzystwa Onkologii i Hematologii Dziecięcej
Authors: Kołtan Sylwia , Urbańczyk Anna , Grześk Elżbieta , Dąbrowska Anna , Ewertowska Marlena , Kałwak Krzysztof , Szczepański Tomasz , Młynarski Wojciech , Wysocki Mariusz , Styczyński Jan 
Published: December 2019

StreszczenieZakażenia są jednym z największych zagrożeń dla chorych w trakcie i po leczeniu chorób nowotworowych. Dla dzieci z nieonkologicznymi schorzeniami hematologicznymi infekcje wiążą się ze zwiększonym ryzykiem powikłań, a także mogą być czynnikiem spustowym wystąpienia lub zaostrzenia problemu zdrowotnego. Jedynym skutecznym i bezpiecznym sposobem zapobiegania zakażeniom są szczepienia ochronne. Zalecenia odnośnie do ich realizacji zmieniają się w czasie, w zależności od aktualnej sytuacji epidemiologicznej, dostępu do szczepionek, a także danych dotyczących bezpieczeństwa ich stosowania w grupach ryzyka. Prezentowana praca przedstawia aktualne rekomendacje Polskiego Towarzystwa Hematologii i Onkologii Dziecięcej, dotyczące zasad immunizacji dzieci z chorobami nowotworowymi i schorzeniami hematologicznymi.
Profilaktyka reaktywacji zakażeń HBV – rekomendacje grupy roboczej profilaktyki reaktywacji HBV
Authors: Pawłowska Małgorzata , Flisiak Robert , Gil Lidia , Horban Andrzej , Hus Iwona , Jaroszewicz Jerzy , Lech-Marańda Ewa , Styczyński Jan 
Published: December 2019

StreszczenieReaktywacja zakażenia HBV jest istotnym problemem u chorych poddawanych terapiom, które poprzez działanie immunomodulujące wpływają na upośledzenie odporności przeciwwirusowej, takim jak: leczenie biologiczne (np. przeciwciała monoklonalne powodujące deplecję limfocytów CD20, przeciwciała anty-TNF), chemioterapia, leczenie immunosupresyjne (np. kortykosteroidy, cyklosporyna, azatiopryna). Ryzyko reaktywacji wiąże się również z nowymi terapiami stosowanymi w leczeniu nowotworów hematologicznych, takimi jaki inhibitory kinaz tyrozynowych, inhibitory proteasomu czy przeciwciało anty-CD38, daratumumab. Populacją szczególnie zagrożoną są chorzy poddawani transplantacji komórek krwiotwórczych, w szczególności chorzy po transplantacji allogenicznej, u których prowadzone jest leczenie immunosupresyjne. W pracy przedstawiono epidemiologię, czynniki ryzyka reaktywacji oraz aktualne zasady postępowania dotyczące profilaktyki reaktywacji zakażenia HBV.
Lichens from Sisimiut in West Greenland and their Climatic Preferences
Authors: Hansen Eric Steen 
Published: December 2019

AbstractA total of 165 lichen taxa collected from Sisimiut in West Greenland in summer 2017 were reported and categorized toward their climatic preferences. Almost 68% of the 165 lichens are more or less equally distributed in continental and oceanic areas of Greenland. More than 26% of the lichens occur most frequently in oceanic areas and more rarely in continental areas. Almost 5% of the lichens occur most frequently in continental areas and more rarely in oceanic areas. Two lichens are distinctly oceanic. No distinctly continental lichens were found in the present investigation. The results are in good accordance with those obtained from similar investigations in West Greenland. Two different climatic scenarios and their influence upon the lichen communities are discussed.
Effect of Nanofertilizers and Biofertilizers on Yield of Maize: Biplot Analysis
Authors: Nouraein Mojtaba 
Published: December 2019

AbstractOne of the newest and most interesting fields of science is nanotechnology, which is exploiting many areas such as life sciences; however, its application in agriculture is rarely studied. In order to examine the environmentfriendly fertilizers (nano-sized and biological fertilizers), and control the agricultural nonpoint source pollution from the source, a field experiment was arranged to study the effects of bulk fertilizers (NPK, nitrogen biofertilizer, and phosphorus biofertilizer), nanofertilizers (nanoboron, nanozinc and nanocomplete) and no fertilizer treatment (control) on morphological traits of maize. The first two Principal Components (PCs) were used to create a biplot, which accounted for 72% of the variance of the treatment × trait interaction. The nanozinc fertilizers following nanoboron fertilizer were the best in most of the biological yield, seed yield, harvest index, and 100-grain weight. The vector-view biplot revealed a strong positive association between chlorophyll and protein content, seed yield with the number of kernels per ears and the number of rows per kernel. Nanocomplete fertilizer was the best treatment for chlorophyll content, protein percent and straw yield, while NPK did not high increase in the most traits of maize. This investigation indicated that treatment × trait biplot can graphically show the interrelationships among traits and facilitate visual comparison of fertilizers. In conclusion, it was found that zinc and boron nanofertilizers increased the production of most of the traits in maize. This study indicated that nano types of fertilizers could promote the studied traits in maize plant.
Photoautotrophic Production of Hydrogen in Carteria Crucifera AARL G045 Co-Cultured with Bacterial Flora
Authors: Duangjan Kritsana , Nakkhunthod Watsamon , Pumas Chayakorn 
Published: December 2019

AbstractThis study reports on high potential of photoautotrophic biohydrogen production in co-culture of the novel hydrogen producing microalga Carteria crucifera AARL G045 with its bacterial flora. Hydrogen production from immobilised and free cells were compared under photoautotrophic and photofermentation conditions. Two bacterial floras of Carteria crucifera AARL G045 cultures were isolated and identified by 16S rDNA sequence analysis as Agrobacterium tumefaciens G045-01 and Aeromicrobium kwangyangensis G045-02. As a result, co-culture of Carteria crucifera AARL G045 and A. kwangyangensis G045-02 generated higher level of hydrogen gas than that of the mono algal culture by about 1.32 times. In addition, co-culture of both free cells of the microalga and the bacterium produced higher hydrogen than both co-immobilisation in calcium alginate by about 2.04 times.
Security and immigration: national and European policies in the globalized era
Authors: Romano Felice 
Published: December 2019

Abstract
The article presents a study on migration flows in the countries of the European Union, with a focus on Italy and the policies implemented to ensure the countries’ security. It is necessary to carefully verify the structural forces and the national and international connections that are the direct cause of contemporary migration, rooted in colonialism, war and military occupation, labour recruitment and economic interaction. The author has tried to analyze the issue of immigration by comparing ISTAT22 and EUROSTAT23 data, analyzing European and national policies to tackle this issue and verify how these are implemented for making European society democratic, welcoming and secure.
The status of journalism and journalist education in india
Authors: Viktorovich Matvienko Valentin 
Published: December 2019

Abstract
Journalistic education in India in the context of booming media sector is a relatively new topic of scientific interest in the Russian Federation. The object of scientific research is vast: it includes a numerous list of problems and specific circumstances of the Indian national level concerning the freedom of journalism as a social institution and consists of fragmentary issues such as the rights of journalists, peculiar properties of journalistic trainings in India and their practical realization. It should be mentioned that journalistic education in India is a peculiar system with its specific structure, concrete goals and traditional objectives.The article is devoted to the analysis of the Indian national system of journalists training and its role in the social and partly “ political environment of the country. As the topic is rather complicated, the author researches different aspects of journalistic education in India: the process of forming the professional ethics, working on the qualification upgrade, communication with the audience and other media workers. After the conducted research the author concludes that despite the improving economic policy of the country and growing role of social responsibility, the Indian journalists are in their mass still poorly qualified on the one hand and the editorial policy doesn’t objectively reflect the kaleidoscopically changing economic and social conjuncture of the country” on the other hand.