bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Disease Severity and Health-Related Quality of Life in Patients with Rheumatoid Arthritis Undergoing Total Knee Arthroplasty
Authors: Rahimnia Alireza , Alishiri Gholamhossein , Bayatpoor Mohammad E. , Hosseini Mohammad A. , Najafizadeh-Sari Shahriar , Yaribeygi Habib , Sahebkar Amirhossein 
Published: July 2020

Background:
The Total Knee Arthroplasty (TKA) is one of the most common surgical
intervention in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Previous studies
suggested a significant improvement in health status after TKA surgery. But we have little data
about the Iranian population undergone TKA. In the current clinical study, we evaluated postoperatively
health status using reliable tools of MOS SF-36 and WOMAC in OA and RA patients
undergoing TKA.

Methods:
In this cohort study, patients with OA and/or RA who were candidates for TKA surgery
were included. Using two reliable questionnaires, i.e., WOMAC and SF-36, the quality of life of
patients was examined during a period of six months (three monthly intervals) after the surgery. All
data were analyzed using IBM SPSS Statistics. Kolmogrov-Smirnov, Kendall’s tau, chi-square test
and K-related Non-parametric tests were used.

Results:
Of the 2126 patients who underwent TKA, there were 2024 diagnosed osteoarthritis and
102 validated RA over one year. The mean ± SD of age and the average BMI were 68.0 ± 7.0 BMI
28.5 kg/m2, respectively. Regarding comorbidities and concurrent disorders, about 14% of cases
were diabetic, 42% had cardiovascular diseases, 3% had respiratory diseases, and 12% involved
with gastrointestinal diseases. The result of SF-36 dramatically increased during follow up. The
central distributions of all domains in the SF-36 questionnaire indicated that most scores increased
during the time after surgery. As a consequence, WOMAC and MOS FS-36 indicated statistically
significant changes after TKA for those who are suffering from RA or OA.

Conclusion:
TKA is an effective surgical process, which improves the quality of life in OA and/or
RA. In addition, WOMAC and SF-36 examining tools are likely reliable tools with similar results
to assess patients’ quality of life after TKA surgery.
EVALUATION OF ACUTE AND SUB-ACUTE ORAL TOXICITY OF CLINACANTHUS NUTANS LEAVES EXTRACT IN MICE
Authors: GIANG TRAN THI LINH , THACH LE KIM , LINH LE NGUYEN TU , DAO VU QUANG , BEN TRINH THI , THACH BUI DINH 
Published: July 2020

Objective: This study aimed to evaluate acute and sub-acute oral toxicity of ethanol extract of Clinacanthus nutans leaves in Swiss mice.
Methods: Acute oral toxicity study was performed as per OECD-423 guidelines. Sub-acute oral toxicity study was performed as per OECD-407 guidelines. The extract was dissolved in 10% dimethyl sulfoxide and administered orally, while the control group received only the vehicle.
Results: The acute oral toxicity test on mice showed that this extract was well tolerated up to LD50 5000 mg/kg body weight/day oral dosage level and non-toxic to mice under the present experimental conditions. The sub-acute toxicity study was carried out on mice with the oral dosage of the extract from 100 mg/kg–500 mg/kg body weight/day and 5000 mg/kg body weight/day for 28 d. The results showed that this extract did not induce death or adverse effects in activity, feed consumption or body weight gain. There were not significant changes in heamotological and biochemical parameters between control and experiment groups.
Conclusion: Thus, Clinacanthus nutans leaf has a very low toxicity value.
THE IMPORTANCE OF ANTIBIOTICS IN A VARIOUS UNIQUE METASTASIS ALONG WITH CYTOTOXIC THERAPY AT TERTIARY CARE HOSPITAL: A PROSPECTIVE COHORT STUDY
Authors: KIRAN G. SAI , KUMAR N. DOONDI PHANI 
Published: July 2020

Objective: Rare cancers are creating a massive challenge to the world. It has associated with genetic mutations or socio-environmental factors, which includes genes, smoking, alcohol, ionizing radiation exposure, organic-inorganic chemicals, air and water pollution, viruses, and bacteria. When 15 cases per 1,00,000 people per year, we can consider it as a rare case as per the National Cancer Institute
This study aim is the importance of antibiotics in various unique metastasis along with cytotoxic therapy at tertiary care hospital.
Methods: The inclusion criteria of our study include a person who is suffering from rare metastasis at an early stage. We excluded the data that are those who are suffering from the typical type of cancers, multiple co-morbid conditions. This study was carried out the Prospective Cohort Study conducted between June 2018 to March 2020.
Results: Number of 20 rare cancers we consider for final analysis, the overall antibiotics use in this study 18 antibiotics they prescribed in overall cases, prescribed cytotoxic drugs are 23. the chi-square test value is P=0.001, the confidence interval(CI) is 95%, the likelihood ratio is 54.4, odd’s ratio is 2.0(CI 95%, P=0.711), Male patients more than the female patients.
Conclusion: Cancer is a complex disorder, which is occurred through gene proliferation and socio-environmental factors. Rare metastasis is challenging to physicians and patients, however as per our observation, cytotoxic therapy with antibiotics can reduce the risk of rare metastasis and as well improved therapeutic adhesion, and we need clear supporting evidence on it through clinical trials.
NATURAL COMPOUNDS FROM DJIBOUTIAN MEDICINAL PLANTS AS INHIBITORS OF COVID-19 BY IN SILICO INVESTIGATIONS
Authors: ELMI ABDIRAHMAN , SAYEM S. AL-JAWAD , AHMED MOHAMED , ABDOUL-LATIF FATOUMA 
Published: July 2020

Objective: The new coronavirus type SARS-Cov 2 (severe acute respiratory syndrome), which appeared in autumn 2019 in China, became a global pandemic in a few months. In this work, we looked for the potential anti SARS-Cov 2 of the compounds isolated from three Djiboutian medicinal plants, namely Acacia seyal, Cymbopogon commutatus, and Indigofera caerulea.
Methods: We carried out a molecular docking with nine biomolecules, β-Sitosterol, Quercetin, Catechin, Lupeol, Rutin, Kaempferol, Gallic acid, Piperitone and Limonene on three target sites which are SARS-CoV-2 main protease (Mp), SARS-CoV-2 receptor-binding domain (RBD) and human furin protease. These targets are chosen because of their role in the process of penetration of the virus into human cells and its multiplication. Moreover, the predictions of pharmacokinetic parameters as well as toxicological properties have been determined using an online bioinformatics tool named SwissADME and AdmetSAR respectively.
Results: The phenolic compounds have a very good affinity on these three target sites with binding energies of up to-9.098 kcal/mol for rutin on SARS-CoV-2 Mp, much better than the two reference drugs hydroxychloroquine (-5.816 kcal/mol) and remdesivir (-7.194 kcal/mol). Except for β-Sitosterol, the tested biomolecules have weak toxicity.
Conclusion: These natural compounds can be used against covid 19 pending In vitro and In vivo evaluations.
HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB
Authors: KARAJGI SANTOSH , POTADAR SHRIPAD 
Published: July 2020

Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water.
Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model.
Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration.
Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.
IN VITRO EVALUATION OF IMMUNOMODULATORY ACTIVITY OF ETHANOLIC EXTRACT OF MORINGA CONCANENSIS NIMMO
Authors: SINGUNE SHANTILAL , VAGHELA J. S. 
Published: July 2020

Objective: The present study was undertaken to evaluate immunomodulatory activity of ethanolic extract and isolated compound from the whole plant of Moringa concanensis Nimmo
Methods: Immunomodulatory activities were determined by in vitro models-plaque-forming cell assay, nitric oxide (NO) radical scavenging activity, inhibit RAW 264.7 macrophage cell line from generating harmful NO induced by lipopolysaccharide (LPS) and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay.
Results: Showed significant (P<0.01) phagocytic effect on human neutrophils in the parameters studied. Scavenged nitric oxide radical by ethanolic extract of Moringa concanensis inhibition 34% and isolated compound scavenged nitric oxide radical inhibition 44% respectively compared to control group exerted 52% decrease of nitric oxide radical respectively concentration at 0.1,0.01 and1.0 mg/ml. LPS in murine macrophage, RAW 264.7 cells culture medium induced a high release of NO but pretreatment with Moringa concanensis extract and isolated compound resulted in inhibition of NO production by 29, 37, 95 % and 32,44,96 % at concentrations of 0.5, 0.1 and 1.0 mg/ml, compared to LPS-induced sample. ethanolic extract and isolated compound significantly stimulate RAW 264.7 cell viability (P<0.001) by MTT assay.
Conclusion: The present experimental finding demonstrated that isolated compound has superior immunomodulatory activity than the ethanolic extract of Moringa concanensis this effect presumably due to the greater ability of an isolated compound to boost the innate and adaptive immune system.
UKURAN PERUSAHAAN DAN PROFITABILITAS SEBAGAI DETERMINAN NILAI PERUSAHAAN MANUFAKTUR DENGAN STRUKTUR MODAL SEBAGAI VARIABEL MEDIASI
Authors: Astakoni Made 
Published: July 2020

Penelitian ini memiliki beberapa tujuan yaitu; 1) untuk mengetahui dan menganalisis pengaruh ukuran perusahaan (size) terhadap nilai perusahaan ; 2) untuk mengetahui dan menganalisis pengaruh ukuran perusahaan terhadap struktur modal;3) untuk mengetahui dan menganalisis pengaruh profitabilitas terhadap struktur modal; 4) untuk mengetahui dan menganalisis pengaruh profitabilitas terhadap nilai perusahaan; 5) untuk mengetahui dan menganalisis pengaruh struktur modal terhadap nilai perusahaan; 6) untuk mengetahui dan menganalisis peran struktur modal dalam memediasi hubungan ukuran perusahaan dengan nilai perusahaan;7) untuk mengetahui dan menganalisis peran struktur modal dalam memediasi hubungan profitabilitas dengan nilai perusahaan. Populasi dalam studi ini adalah perusahaan manufaktur sektor kosmetik dan keperluan rumah tangga yangterdaftar di Bursa Efek Indonesia (BEI) periode 2011-2018. Pengambilan sampel dilakukan secara purposive dengan kriteria yang telah ditetapkan sebelumnya. Analisis data studi ini menggunakan pendekatan Partial Least Square (PLS). Hasil perhitungan menunjukkan bahwa hipotesis pertama;yang menyatakan bahwa terdapat pengaruh signifikan positif antara ukuran perusahaan terhadap nilai perusahaan tidak dapat diterima. Hipotesis kedua yang menyatakan ukuran perusahaan (size) berpengaruh positif signifikan terhadap struktur modal tidak dapat diterima. Hipotesis ketiga yang menyatakan profitabilitas (profitability) berpengaruh negatif signifikan terhadap struktur modal tidak dapat diterima Hipotesis keempat yang menyatakan bahwa terdapat pengaruh signifikan positif antara profitabilitas terhadap nilai perusahaan dapat diterima. Hipotesis kelima yang menyatakan bahwa terdapat pengaruh signifikan positif antara struktur modal terhadap nilai perusahaan tidak dapat diterima. Berdasarkan perhitungan, variable struktur modal belum mampu menjadi variable mediasi dalam mengintervensi pengaruh ukuran perusahaan terhadap nilai perusahaan.Sedangkan pada sisi lain variable struktur modal mampu menjadi mediasi dalam mengintervensi pengaruh profitabilitas terhadap nilai perusahaan.
The Use of Swear Words in the Movies with Different Topics and Characters
Authors: Rinaldi Rizki 
Published: July 2020

This study was aimed at examining the use of swear word in the movies with different topics and characters. The objectives if this study were to find out the reasons of using swear word in the movies. This study was conducted by descriptive qualitative method. The source of data was transcript the movies. The data were identified, analyzed, and categorized based on L,jung ( 2012 ) theory. The technique of data collection was interactive model by Miles and Huberman ( 2014 ). The findings of the study showed that : 1. There are three ways of using swear words such as (1) interjection, (2) emphasizer, (3), expletive slot filler in each movies, but from all of that ways interjections is the most in each movies. 2. The reasons for using the swear words in the movies are psychological; and social movies.
Praktik Ritual Mopo’a Huta (Memberi Makan pada Tanah) pada Masyarakat Gorontalo di Desa Molamahu
Authors: A. Hunowu Momy , Badu Pakuna Hatim 
Published: July 2020

The mopo’a huta ritual is a ritual practiced by Gorontalo people when the dry season arrives. By carrying out this ritual, people believe that rain will fall and fertility and prosperity will come. This ritual has been carried out since hundreds of years ago, but nowadays it has begun to be opposed by several groups. This study aims to find out how the practice of the mopo'a Huta ritual, how the public view of the mopo'a huta ritual using Geertz's perspective. The study used a qualitative approach with case studies, conducted interviews with the organizers, made observations during the procession, and explored the results of previous research. The study found that the mopo'a huta ritual in practice held a dance (dayango) accompanied by the wasps of towohu (drums) for several nights. At the peak of the ritual, offerings were made consisting of certain ingredients to be presented to supernatural beings as the rulers of nature. For this practice, there are 3 community groups 1) the abangan group, namely the traditional farmers who still hold the tradition, 2) the santri group, namely the educated community as a group of modern farmers, some of whom still believe and some do not believe because there is already technology that can solve problems, 3) priyai groups, namely village heads. In the past, the village head was the main supporter of the mopo'a huta ritual, while at present, the village head secures himself in the middle position.
ABSTRAK
Ritual mopo’a huta adalah ritual yang dipraktikkan masyarakat Gorontalo ketika musim kemarau tiba. Dengan melaksanakan ritual ini, masyarakat meyakini hujan akan turun serta kesuburan dan kemakmuran akan datang. Ritual ini dilaksanakan sejak ratusan tahun silam, namun dewasa ini mulai ditentang oleh beberapa kalangan. Penelitian ini bertujuan untuk mengetahui bagaimana praktik ritual mopo’a Huta, bagaimana pandangan masyarakat tentang ritual mopo’a huta dengan menggunakan perspektif Geertz. Penelitian menggunakan pendekatan kualitatif dengan studi kasus, melakukan wawancara dengan tokoh-tokoh penyelenggara, melakukan pengamatan selama prosesi itu dilaksanakan, serta menggali hasil-hasil penelitian terdahulu. Penelitian menemukan bahwa ritual mopo’a huta dalam praktiknya menggelar tarian (dayango) diiringi tabuhan towohu (gendang) selama beberapa malam. Pada puncak ritual digelar sesajian yang terdiri dari bahan-bahan tertentu untuk dipersembahkan kepada mahluk gaib sebagai penguasa alam. Terhadap praktik ini, terdapat 3 kelompok masyarakat 1) kelompok abangan, yaitu kalangan petani tradisional yang masih erat memegang tradisi, 2) kelompok santri, yaitu kalangan masyarakat terdidik sebagai kelompok petani modern, kalangan ini sebagian masih percaya dan sebagian lagi tidak percaya karena sudah ada teknologi yang dapat menyelseaikan masalah, 3) kelompok priyai, yaitu kepala desa. Pada masa lalu, kepala desa sebagai pendukung utama ritual mopo’a huta, sementara pada masa kini, kepala desa berada dipersimpangan.
Study the Effect of pH on the Fermentation Anaerobic-Aerobic Siwalan (Borassus flabellifer L.) Sap to Produce Acetic Acid
Authors: Agustiani Elly , Susilaningrum Destri , Rahmawati Atiqa , Z.L. Fibrillian , L.R. Dimas 
Published: July 2020

This research is to study the effect of ethanol fermentation aerobic pH on acetic acid product. Anaerobic fermentation uses saccharomyces cerevisiae to produce ethanol, and aerobic fermentation uses acetobacter acetic for acetic acid production. In aerobic ethanol fermentation using pH 3; 3.5; 4 and 5. The ethanol concentration was evaluated using GC ULTRA Scientific Gas Chromatography, DSQ II detector, and MS 220 column. Acetic acid produced was analyzed using an alkalymetric method. Anaerobic fermentation uses Saccharomyces cerevisiae with 1-day log phase, while aerobic fermentation uses acetobacter aceti with a 5-day log phase. Fermentation using saccharomyces cerevisiae within 24 hours so that reduction sugar could stably decrease, optimum ethanol could be got at optimum pH 6 which could decrease 55 % of reducing sugar concentration to produce 8,20583 %v/v ethanol. Fermentation acetate acid content observed in 3 days at pH 6 and 30 ⁰C will produce 6,659 g/l also shows that pH 4-6 at 30 ⁰C will produce 6,605 g/l acetate acid. Aerobic fermentation of acetate acid in 3 days shows that pH 4-6 is highly affected by temperature at 30⁰C. Statistical analysis shows, in ethanol production pH and fermentation time give significant effect, but interaction has no significant effect.
An overview of patterns and trends in nursing publications from the People's Republic of China
Authors: Timmins Fiona 
Published: July 2020

Abstract

Objective
To explore patterns and trends in nursing publications from the People's Republic of China.

Methods
Using the Scopus online database, the author performed two searches in August 2019. The first search identified all items in the category of nursing affiliated to China, and the second search identified publications from China within one specific nursing journal. The author used a theoretical framework to provide a more in-depth understanding of patterns and trends within these items.

Results
The number of articles categorized as nursing, with listed authorship in China, within the Scopus database was 17,506. The majority of published papers were categorized as research. Top-ranking Chinese universities, such as Peking University and Fudan University, scored high in terms of several publications listed within the database. Although categorized as nursing, the most common source titles that are mostly high-ranking journals did not feature the high-ranking nursing journals. Identified authors were generally not affiliated with nursing schools. Focused analysis of one of the top-ranking nursing journals, the Journal of Nursing Management, featured top Chinese universities and consistent nursing authorship. Nursing authors were found to have lower h-indices than international nursing professors.

Conclusions
There has been a steady increase year by year in publications categorized as nursing from China since 2009, with the majority of published papers categorized as research. There is clear evidence of scholarly activity in nursing in China, both in the published literature and anecdotally in practice. However, nursing scholars need to do more to increase dissemination and ensure that nursing professors are leading and driving nursing research, although in a multidisciplinary context. There is also a need for increased exposure of Chinese nursing scholarship in high-ranking nursing journals.
Performance problems and how to address them in the 9th century Ah.
Authors: Arabiyat Ekram Abdul Razzaq Abdullah 
Published: July 2020

This research deals with solutions to the most important performance problems and how to address them when readers of Sham in the 9th century AH through references and followers to read the Messenger of God, as the scholars said that reading is a follow-up year taken by the other from the first, and I ask God to accept what he loves and accepts.
And that we have come to this study to benefit Islam and Muslims.
CORRELATES OF NON-ADHERENCE TO HOME EXERCISE PROGRAMMES IN PATIENTS WITH LOW BACK PAIN
Authors: ODEBIYI DO , FAPOJUWO OA , OLALEYE BF , OLANIYAN AS 
Published: July 2020

Background: Non-adherence to home exercise programmes may lead to delayed progress in recovery and diminished clinical outcomes in patients.
Aims of Study: To determine the adherence rate and attributing factors to non-adherence to home exercise programmes in patients with low back pain (LBP).
Method: A total of 250 patients with LBP receiving treatment in 5 different out-patient physiotherapy clinics in Lagos State South West, Nigeria participated in this survey. They were required to complete a 27- item questionnaire which collected information on characteristics of participants and home exercise programme, adherence with treatment programme and instructions for carrying out the exercises. Gamma correlation and Chi-square were used to detect the correlation and significant difference of selected variables respectively. The level of significance was set at p< 0.05
Result: Ninety-four (37.6%) respondents performed home exercise programme the recommended number of times daily. There was no significant relationship (p> 0.05) of participants’ characteristics, frequency and duration of exercise per session, total number and manner of recommending the home exercise programme and pain rating respectively with adherence to home exercise programme. Eighty-nine (35.6%) respondents complained of tiredness after the day’s work. Chi-square showed significant association (p<0.05) of the prescribed home exercises programme, the actual exercise carried out at home with their perception to home exercise programme
Conclusion: Home exercise programmes may interfere with normal life and daily routine in patients with LBP. It is recommended that home exercise programme be patient centred I.e. fit into individual daily routine to overcome identified barriers.
O Teatro do Oprimido: dimensões políticas e pedagógicas em perspectiva freiriana
Authors: Viana de Souza Silva Francenilza , Vale da Costa Selda 
Published: July 2020

O artigo objetiva articular a arte teatral às críticas do contexto social, a partir das concepções teóricas e metodológicas do Teatro do Oprimido, de Augusto Boal. Portanto, trata-se de um estudo teórico que analisa o método teatral que está inserido na proposta do teatro político desse autor, estruturado a partir de seis técnicas que objetivam aproximar o teatro das grandes massas. A prática do Teatro do Oprimido amplia horizontes, exercita a prática do diálogo com diferentes campos do saber. Daí a importância de se conhecerem as conexões existentes entre os fundamentos que embasam esta teoria teatral e a teoria de Paulo Freire. Conclui-se que o Teatro do Oprimido, articulado às perspectivas freiriana, é uma alternativa para que os atores sociais reflitam sobre as formas de opressões presentes na sociedade, para romper com as relações verticalizadas, autoritárias e centralizadoras, uma vez que estabelece uma relação horizontal entre elas, contribuindo para que questionem e discutam suas práticas de cidadãos.
Palavras-Chave: Teatro do Oprimido. Augusto Boal. Educação. Paulo Freire.