bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic changes after spinal anesthesia in preeclamptic patients undergoing cesarean section at a tertiary referral center in Ethiopia: a prospective cohort study
Authors: Alemayehu Tikuneh Yetneberk , Berhe Yophetah Woldegerima , Getnet Habtamu , Molallign Mamaru 
Published: March 2020

AbstractBackgroundSpinal anesthesia-induced maternal hypotension is the most frequent complication associated with maternal morbidity and mortality during Cesarean section. The aim of this study was to compare the incidence and magnitude of hemodynamic changes in preeclamptic and non-preeclamptic parturients undergone Cesarean section under spinal anesthesia.MethodA prospective cohort study was conducted from 01 February to 28 May 2019 in preeclamptic and non-preeclamptic parturients. We hypothesized preeclamptic parturients are at high risk of spinal anesthesia induced hypotension than non preeclamptics. A total of 122 ASA II and ASA III parturients were recruited consecutively and assigned to two groups (81non-preeclamptics, and 41 preeclamptics). Parturients with cardiac disease, twin pregnancy, chronic hypertension, gestational hypertension, superimposed hypertension, renal disease, diabetes mellitus, coagulopathy (platelet count < 80 × 109/L), active labor, eclampsia, abruptio placentae, placenta praevia, any adjuvant added with local anesthetics were excluded. The data analysis was done using SPSS version 22 statistical software. Student t test, MannWhitney U test and Fisher exact test were used to compare the data. AllPvalues < 0.05 were considered statistically significant.ResultThe incidence of spinal anesthesia-induced hypotension was higher in non-preeclamptic parturients than preeclamptic parturients (55.6% vs. 34.1%, respectively) and the degree of blood pressure drop was significantly greater in the non-preeclamptic parturients compared to those with preeclampsia; As well intraoperative fluid consumption was significantly greater in the non-preeclamptics parturients compared to those with preeclamptics.ConclusionThe incidence and magnitude of spinal anesthesia-induced hypotension in parturients undergone Cesarean section were less in preeclamptic parturients than in non-preeclamptic parturients.. Based on the data from this study we recommended spinal anesthesia for preeclamptic patients, unless there is a contra indication based on preeclampsia.
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
Authors: Liu S. John , Malatesta Martina , Lien Brian V. , Saha Parna , Thombare Shivani S. , Hong Sung Jun , Pedraza Leslie , Koontz Mark , Seo Kyounghee , Horlbeck Max A. , He Daniel , Birk Harjus S. , Jain Miten , Olsen Hugh E. , Akeson Mark , Weissman Jonathan S. , Monje Michelle , Gupta Nalin , Raleigh David R. , Ullian Erik M. , Lim Daniel A. 
Published: March 2020

Abstract
Background
Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the context of currently used cancer treatments. Malignant glioma is rapidly fatal, and ionizing radiation is part of the current standard-of-care used to slow tumor growth in both adult and pediatric patients.

Results
We use CRISPR interference (CRISPRi) to screen 5689 lncRNA loci in human glioblastoma (GBM) cells, identifying 467 hits that modify cell growth in the presence of clinically relevant doses of fractionated radiation. Thirty-three of these lncRNA hits sensitize cells to radiation, and based on their expression in adult and pediatric gliomas, nine of these hits are prioritized as lncRNA Glioma Radiation Sensitizers (lncGRS). Knockdown of lncGRS-1, a primate-conserved, nuclear-enriched lncRNA, inhibits the growth and proliferation of primary adult and pediatric glioma cells, but not the viability of normal brain cells. Using human brain organoids comprised of mature neural cell types as a three-dimensional tissue substrate to model the invasive growth of glioma, we find that antisense oligonucleotides targeting lncGRS-1 selectively decrease tumor growth and sensitize glioma cells to radiation therapy.

Conclusions
These studies identify lncGRS-1 as a glioma-specific therapeutic target and establish a generalizable approach to rapidly identify novel therapeutic targets in the vast non-coding genome to enhance radiation therapy.
Multimodular fused acetyl–feruloyl esterases from soil and gut Bacteroidetes improve xylanase depolymerization of recalcitrant biomass
Authors: Kmezik Cathleen , Bonzom Cyrielle , Olsson Lisbeth , Mazurkewich Scott , Larsbrink Johan 
Published: March 2020

Abstract
Background
Plant biomass is an abundant and renewable carbon source that is recalcitrant towards both chemical and biochemical degradation. Xylan is the second most abundant polysaccharide in biomass after cellulose, and it possesses a variety of carbohydrate substitutions and non-carbohydrate decorations which can impede enzymatic degradation by glycoside hydrolases. Carbohydrate esterases are able to cleave the ester-linked decorations and thereby improve the accessibility of the xylan backbone to glycoside hydrolases, thus improving the degradation process. Enzymes comprising multiple catalytic glycoside hydrolase domains on the same polypeptide have previously been shown to exhibit intramolecular synergism during degradation of biomass. Similarly, natively fused carbohydrate esterase domains are encoded by certain bacteria, but whether these enzymes can result in similar synergistic boosts in biomass degradation has not previously been evaluated.

Results
Two carbohydrate esterases with similar architectures, each comprising two distinct physically linked catalytic domains from families 1 (CE1) and 6 (CE6), were selected from xylan-targeting polysaccharide utilization loci (PULs) encoded by the Bacteroidetes species Bacteroides ovatus and Flavobacterium johnsoniae. The full-length enzymes as well as the individual catalytic domains showed activity on a range of synthetic model substrates, corn cob biomass, and Japanese beechwood biomass, with predominant acetyl esterase activity for the N-terminal CE6 domains and feruloyl esterase activity for the C-terminal CE1 domains. Moreover, several of the enzyme constructs were able to substantially boost the performance of a commercially available xylanase on corn cob biomass (close to twofold) and Japanese beechwood biomass (up to 20-fold). Interestingly, a significant improvement in xylanase biomass degradation was observed following addition of the full-length multidomain enzyme from B. ovatus versus the addition of its two separated single domains, indicating an intramolecular synergy between the esterase domains. Despite high sequence similarities between the esterase domains from B. ovatus and F. johnsoniae, their addition to the xylanolytic reaction led to different degradation patterns.

Conclusion
We demonstrated that multidomain carbohydrate esterases, targeting the non-carbohydrate decorations on different xylan polysaccharides, can considerably facilitate glycoside hydrolase-mediated hydrolysis of xylan and xylan-rich biomass. Moreover, we demonstrated for the first time a synergistic effect between the two fused catalytic domains of a multidomain carbohydrate esterase.
What evidence exists for the impact of Baltic Sea ecosystems on human health and well-being? A systematic map protocol
Authors: Storie Joanna , Suškevičs Monika , Külvik Mart , Lehtoranta Virpi , Vikström Suvi , Riikonen Simo , Kuosa Harri , Kuhn Kristin , Oinonen Soile 
Published: March 2020

Abstract
Background
The Baltic Sea ecosystems supply many benefits to society, termed ecosystem services. These depend upon a healthy marine environment requiring marine and relevant land-based policies integrated with public health policies. Until recently marine environment protection policies have largely focussed on human impacts on the environment and have not taken into account impacts of ecosystems on human health beyond the direct impacts of hazardous substances, such as those present in seafood. Whilst endeavours have been made to integrate human health and well-being into marine policies, interviews with key stakeholders through a participatory process revealed that the linkages were not sufficiently strong to inform policymaking. The existing evidence base urgently needs to be identified and synthesised to support relevant policy updates of the Marine Strategy Framework Directive (MSFD) 2008/56/EC and the Baltic Sea Action Plan (BSAP) (2007) as well as to help direct future research priorities.

Method
The protocol is based on the primary question, “What linkages have been researched between Baltic Sea ecosystems and the positive and negative impacts to human health and well-being?” Using systematic mapping, this study will identify and map the state and the geographical distribution of the existing research evidence linking human health and well-being with the Baltic Sea ecosystems. The types of ecosystem services supplied by the Baltic Sea and the associated health and well-being impacts will be categorised and presented in a graphical matrix, illustrating ecosystem service type and the types of health and well-being outcomes. The systematic mapping procedure will result in a narrative report published with a searchable database, which will contain a descriptive summary of the information from all of the eligible studies. The systematic map and database will be displayed on the website of the Finnish Environment Institute (SYKE).
Comparison of women with high vs. low food addiction tendency: a pilot study with voxel-based morphometry
Authors: Schienle Anne , Unger Isabella , Wabnegger Albert 
Published: March 2020

Abstract
Background
The concept of ‘food addiction’ (FA) posits that highly processed food with added fat and/or refined carbohydrates is capable of triggering addictive-like eating behavior. FA may be one possible phenotype in obesity.

Methods
The present voxel-based morphometry (VBM) study compared data from three groups of women. One group scored high on the Yale Food Addiction Scale (YFAS) and was overweight (n = 21), whereas the two other groups had low YFAS scores and were either overweight (n = 21) or normal-weight (n = 21).

Results
Overweight women with high YFAS scores had less grey matter volume (GMV) in the inferior frontal gyrus (IFG) than overweight women with low FA tendency, who in turn had less GMV in the IFG than the normal-weight group. The IFG is involved in response inhibition, which is relevant for the control of appetite and food intake. In the group with high FA tendency, the frequency of binge episodes was substantially correlated with the YFAS scores, and 11 women of this group were diagnosed with binge-eating disorder (BED). The association between IFG volume and YFAS scores was not statistically significant anymore when controlling for the effect of binge frequency as revealed by partial correlation analysis.

Conclusion
This VBM study revealed an association between reported FA tendency and a neural correlate of disinhibited eating. Future studies with bigger sample sizes are needed in order to demonstrate that FA is sufficiently different from existing conditions (e.g., BED) to warrant classification as a distinct disease phenotype.
Biomass Smoke Exposure Is Associated With Gastric Cancer and Probably Mediated Via Oxidative Stress and DNA Damage: A Case-Control Study
Authors: Kayamba Violet , Zyambo Kanekwa , Mulenga Chola , Mwakamui Simutanyi , Tembo Mizinga Jacqueline , Shibemba Aaron , Heimburger Douglas Corbett , Atadzhanov Masharip , Kelly Paul 
Published: March 2020

PURPOSE We investigated the association between gastric cancer and environmental and dietary exposures. In addition, we explored probable mechanistic pathways for the influence of biomass smoke on gastric carcinogenesis. PATIENTS AND METHODS The study was conducted in Lusaka, Zambia. Questionnaires were used to collect data on risk factors, whereas enzyme-linked immunosorbent assays and high-performance liquid chromatography were used to measure biologic exposures. Study data were analyzed using contingency tables and logistic regression. RESULTS We enrolled 72 patients with gastric adenocarcinoma and 244 controls. Gastric cancer was positively associated with rural residence (odds ratio [OR], 2.9; 95% CI, 1.5 to 5.3), poverty (OR, 4.2; 95% CI, 1.9 to 9.1), and daily consumption of processed meat (OR, 6.4; 95% CI, 1.3 to 32) and negatively associated with consumption of green vegetables (OR, 0.2; 95% CI, 0.1 to 0.5). Gastric cancer was also associated with biomass smoke exposure (OR, 3.5; 95% CI, 1.9 to 6.2; P < .0001), an association that was stronger for intestinal-type cancers (OR, 3.6; 95% CI, 1.5 to 9.1; P = .003). Exposure to biomass smoke in controls was associated with higher urinary levels of 8-isoprostane ( P < .0001), 8-hydroxydeoxyguanosine ( P = .029), and 1-hydroxypyrene ( P = .041). Gastric cancer was not associated with biochemical measures of current exposure to aflatoxins or ochratoxins. CONCLUSION In Zambia, exposure to biomass smoke, daily consumption of processed meat, and poverty are risk factors for gastric cancer, whereas daily consumption of green vegetables is protective against gastric cancer. Exposure to biomass smoke was associated with evidence of oxidative stress and DNA damage, suggesting mechanistic plausibility for the observed association, and the association was restricted to intestinal-type gastric cancer.
Coherent J/ψ photoproduction in peripheral heavy-ion collisions
Authors: Bugnon O. 
Published: March 2020

Abstract
In 2015, the ALICE Collaboration reported the first measurement of an excess in the yield of

at very low transverse momentum (

) in the forward rapidity region (2.5 < y < 4) in peripheral lead-lead (Pb-Pb) collisions at

at the CERN LHC. The coherent photoproduction was proposed as the potential underlying physics mechanism. This is known to be the main production mechanism for low-

production in ultra-peripheral collisions, which are dominated by electromagnetic interactions. However, the observation of a large effect in more central collisions that are dominated by the hadronic interactions was quite surprising. This article represents a proceeding contribution on the preliminary results from Pb-Pb collisions at

shown in a poster during the National Congress of the French Physics Society in July 2019.
Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay
Authors: Chan Yee-Ming , Lippincott Margaret F , Sales Barroso Priscila , Alleyn Cielo , Brodsky Jill , Granados Hector , Roberts Stephanie A , Sandler Courtney , Srivatsa Abhinash , Seminara Stephanie B 
Published: March 2020

Abstract

Context
The management of youth with delayed puberty is hampered by difficulty in predicting who will eventually progress through puberty and who will fail to attain adult reproductive endocrine function. The neuropeptide kisspeptin, which stimulates gonadotropin-releasing hormone (GnRH) release, can be used to probe the integrity of the reproductive endocrine axis.

Objective
We sought to determine whether responses to kisspeptin can predict outcomes for individuals with pubertal delay.

Design, Setting, and Participants
We conducted a longitudinal cohort study in an academic medical center of 16 children (3 girls and 13 boys) with delayed or stalled puberty.

Intervention and Outcome Measures
Children who had undergone kisspeptin- and GnRH-stimulation tests were followed every 6 months for clinical evidence of progression through puberty. Inhibin B was measured in boys. A subset of participants underwent exome sequencing.

Results
All participants who had responded to kisspeptin with a rise in luteinizing hormone (LH) of 0.8 mIU/mL or greater subsequently progressed through puberty (n = 8). In contrast, all participants who had exhibited LH responses to kisspeptin ≤ 0.4 mIU/mL reached age 18 years without developing physical signs of puberty (n = 8). Thus, responses to kisspeptin accurately predicted later pubertal outcomes (P = .0002). Moreover, the kisspeptin-stimulation test outperformed GnRH-stimulated LH, inhibin B, and genetic testing in predicting pubertal outcomes.

Conclusion
The kisspeptin-stimulation can assess future reproductive endocrine potential in prepubertal children and is a promising novel tool for predicting pubertal outcomes for children with delayed puberty.
LETRAMENTOS DIGITAIS NA FORMAÇÃO CONTÍNUA DE PROFESSORES
Authors: Santos Jefferson Do Carmo Andrade , Soares Leonardo Rodrigo , Boa Sorte Paulo 
Published: March 2020

Os letramentos digitais, agora entendidos como práticas sociais que abarcam o digital e para além do digital, desempenham grande papel na educação contemporânea. No entanto, para que práticas de letramentos digitais sejam contempladas em sala de aula, programas de formação contínua de professores para os letramentos digitais precisam ser empreendidos (MENEZES DE SOUZA, 2011; LANKSHEAR E KNOBEL, 2015; JORDÃO, 2017). Diante disso, o objetivo deste artigo é apresentar possibilidades de formação contínua de professores para os letramentos digitais. Aplicamos questionários a professores da educação básica de escolas públicas de Arraias, Tocantins. Como resultados, constatamos os usos ainda relacionados a fatores técnicos em detrimento dos aspectos críticos e reflexivos.
Monitoring of a hip surveillance programme protects infants from radiation and surgical intervention
Authors: Milligan David J. , Cosgrove Aidan P. 
Published: March 2020

AimsTo monitor the performance of services for developmental dysplasia of the hip (DDH) in Northern Ireland and identify potential improvements to enhance quality of service and plan for the future.MethodsThis was a prospective observational study, involving all infants treated for DDH between 2011 and 2017. Children underwent clinical assessment and radiological investigation as per the regional surveillance policy. The regional radiology data was interrogated to quantify the use of ultrasound and ionizing radiation for this population.ResultsEvidence-based changes were made to the Northern Ireland screening programme, including an increase in ultrasound scanning capacity and expansion of nurse-led screening clinics. The number of infant hip ultrasound scans increased from 4,788 in 2011, to approximately 7,000 in 2013 and subsequent years. The number of hip radiographs on infants of less than one year of age fell from 7,381 to 2,208 per year. There was a modest increase in the treatment rate from 10.9 to 14.3 per 1,000 live births but there was a significant reduction in the number of closed hip reductions. The incidence of infants diagnosed with DDH after one year of age was 0.30 per 1,000 live births over the entire period.ConclusionImproving compliance with the regional infant hip screening protocols led to reduction in operative procedures and reduced the number of pelvic radiographs of infants. We conclude that performance monitoring of screening programmes for DDH is essential to provide a quality service. Cite this article: Bone Joint J 2020;102-B(4):495–500.
Preconditioned Subspace Descent Method for Nonlinear Systems of Equations
Authors: Kaporin Igor 
Published: March 2020

AbstractNonlinear least squares iterative solver is considered for real-valued sufficiently smooth functions. The algorithm is based on successive solution of orthogonal projections of the linearized equation on a sequence of appropriately chosen low-dimensional subspaces. The bases of the latter are constructed using only the first-order derivatives of the function. The technique based on the concept of the limiting stepsize along normalized direction (developed earlier by the author) is used to guarantee the monotone decrease of the nonlinear residual norm. Under rather mild conditions, the convergence to zero is proved for the gradient and residual norms. The results of numerical testing are presented, including not only small-sized standard test problems, but also larger and harder examples, such as algebraic problems associated with canonical decomposition of dense and sparse 3D tensors as well as finite-difference discretizations of 2D nonlinear boundary problems for 2nd order partial differential equations.
Enhancement of mechanical, thermal and water uptake performance of TPU/jute fiber green composites via chemical treatments on fiber surface
Authors: Salem Tuffaha Fathe , Tirkes Seha , Akar Alinda Oyku , Tayfun Umit 
Published: March 2020

Abstract
Chopped jute fiber (JF) surfaces were modified using alkaline, silane and eco-grade epoxy resin. Surface characteristics of jute fibers were confirmed by FTIR and EDX analyses. JF filled polyurethane elastomer (TPU) composites were prepared via extrusion process. The effect of surface modifications of JF on mechanical, thermo-mechanical, melt-flow, water uptake and morphological properties of TPU-based eco-composites were investigated by tensile and hardness tests, dynamic mechanical analysis (DMA), melt flow index (MFI) test, water absorption measurements and scanning electron microscopy (SEM) techniques, respectively. Mechanical test results showed that silane and epoxy treated JF additions led to increase in tensile strength, modulus and hardness of TPU. Glass transition temperature (Tg) of TPU rose up to higher values after JF inclusions regardless of treatment type. Si-JF filled TPU exhibited the lowest water absorption among composites. Surface treated JFs displayed homogeneous dispersion into TPU and their surface were covered by TPU according to SEM micro-photographs.
An Overview of the Carbonatites from the Indian Subcontinent
Authors: Randive Kirtikumar , Meshram Tushar 
Published: March 2020

AbstractCarbonatites are carbonate-rich rocks of igneous origin. They form the magmas of their own that are generated in the deep mantle by low degrees of partial melting of carbonated peridotite or eclogite source rocks. They are known to occur since the Archaean times till recent, the activity showing gradual increase from older to younger times. They are commonly associated with alkaline rocks and be genetically related with them. They often induce metasomatic alteration in the country rocks forming an aureole of fenitization around them. They are host for economically important mineral deposits including rare metals and REE. They are commonly associated with the continental rifts, but are also common in the orogenic belts; but not known to occur in the intra-plate regions. The carbonatites are known to occur all over the globe, majority of the occurrences located in Africa, Fenno-Scandinavia, Karelian-Kola, Mongolia, China, Australia, South America and India. In the Indian Subcontinent carbonatites occur in India, Pakistan, Afghanistan and Sri Lanka; but so far not known to occur in Nepal, Bhutan, Bangladesh and Myanmar. This paper takes an overview of the carbonatite occurrences in the Indian Subcontinent in the light of recent data. The localities being discussed in detail cover a considerable time range (>2400 Ma to <0.6 Ma) from India (Hogenakal, Newania, Sevathur, Sung Valley, Sarnu-Dandali and Mundwara, and Amba Dongar), Pakistan (Permian Koga and Tertiary Pehsawar Plain Alkaline Complex which includes Loe Shilman, Sillai Patti, Jambil and Jawar), Afghanistan (Khanneshin) and Sri Lanka (Eppawala). This review provide the comprehensive information about geochemical characteristics and evolution of carbonatites in Indian Subcontinent with respect to space and time.