bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in vitro study to compare shear bond strength of aged composite to two single-shade composites
Authors: Lahari A. R. , Nainan Mohan Thomas , Nirupama Duddi Narendra , Vijay R. , Thomas Helen , Sharma Ayisha 
Published: December 2024

Aim:
(a) To evaluate and compare the repair bond strength of aged composite to two single-shade composites. (b) To determine the prominent mode of failure.

Materials and Methods:
Thirty composite discs of Filtek 250 (micro hybrid, 3M ESPE, USA) were aged in artificial saliva for 4 weeks and thermocycled for 5000 cycles. The samples were roughened with diamond points (TF12, Mani, Japan) and etched with 37% phosphoric acid. The composite discs were then divided into 3 groups of ten each and the surface was treated with silane coupling agent, followed by bonding agent application. The three groups were restored with one layer of 2-mm thickness of Filtek 250 (Group 1), Omnichroma (Group 2), and Topaz ONE (Group 3) composites, respectively. The samples were subjected to universal testing machine to evaluate the shear bond stress. The detached samples were assessed under 20X stereomicroscope to determine the mode of failure.

Results and Conclusions:
Multiple comparisons between the three groups demonstrated significantly higher mean repair bond strength when the same composite was used for repair and between the two single-shade composites, Omnichroma demonstrated significantly higher repair bond strength (P = 0.002). Within the limitation of this study, it was concluded that repair with the same composite resulted highest repair bond strength, while the single-shade composites provided acceptable repair bond strengths.
Treatment Outcome of Using Guided Bone Regeneration for Bone Augmentation for the Placement of Dental Implants – A Systematic Review
Authors: Chandrasekaran Deepak , Chinnaswami Ravindran , Malathi N. , Jayakumar N. D. 
Published: December 2024

ABSTRACT

Aim:
The objective of this review is to evaluate the treatment outcome differences between guided bone regeneration (GBR) and other techniques of bone augmentation for the placement of dental implants.

Materials and Methods:
This review was performed by two reviewers electronically on the PubMed and Cochrane database for articles published between 1990 and 2023. Only randomized clinical trials (RCTs) and prospective studies were included. Studies involved patients who have been treated with dental implants with simultaneous or previously performed GBR.

Results and Discussion:
A total of 470 studies were identified after implementing the search strategy across the different databases. The results that have been reported may also be influenced by these factors.

Conclusion:
After a careful evaluation of the limited evidence included in studies, it can be concluded that GBR is a stable and effective technique of bone augmentation when compared to block grafting and distraction osteogenesis.
A Comparative Analysis of the Accuracy of Crown Fabricated from Conventional Wax Patterns and CAD/CAM Technology – Milling and 3D Printing
Authors: Kumar MV Sunil , Kumar Rajesh , Saini Ravindher Singh , Vyas Rajesh , Vaddamanu Sunil Kumar 
Published: December 2024

ABSTRACT

Background:
Digital manufacturing techniques such as milling (subtractive) and 3D printing (additive) are increasingly used in dental restorations. These technologies promise enhanced precision and efficiency compared to traditional methods. However, the accuracy of marginal and internal fits of crowns produced by these techniques remains under-explored.

Objective:
To evaluate and compare the marginal and internal fit of dental crowns fabricated using two digital manufacturing techniques: Milling (subtractive) and 3D printing (additive).

Materials and Methods:
A maxillary first molar was replicated to create seven representative dies for each technique. Crowns were fabricated using both milling and 3D printing methods. The fit of the crowns was assessed using the silicone replica technique, measuring occlusal, axial, marginal gaps, and internal fit.

Results:
3D printing demonstrated the most precise fit across all measurement points, with significantly smaller discrepancies compared to milling. The two-way ANOVA analysis confirmed a significant effect of the fabrication method on marginal and internal gaps, highlighting the superior performance of 3D printing. However, the silicone replica technique revealed fewer significant differences between the two methods.

Conclusion:
3D printing offers enhanced precision and consistency in crown fabrication compared to milling. Despite promising results, further research is necessary to confirm the long-term efficacy and cost-effectiveness of these techniques. Future studies should focus on larger clinical cohorts to validate these findings.
Histopathological Insights into Granulomatous Lesions: A Comprehensive Study
Authors: Kumari Archana , Bali Irbinder K. , Chauhan Ayushi , Chitkara Falguni , Wadhera Deepika 
Published: December 2024

ABSTRACT

Background:
Granulomatous inflammation is a persistent inflammatory reaction marked by the presence of aggregations of active histiocytes, epithelioid cells, and multinucleate giant cells. This phenomenon is reported in several viral and non-infectious diseases and is classified as a type IV delayed hypersensitivity response.

Research Materials and Procedures:
The present cross-sectional study was conducted in the histopathology section of the Department of Pathology, MMIMSR, Mullana, from October 2022 to October 2023. A total of 100 cases presenting with granulomatous lesions were analyzed. Detailed clinical data, including age, sex, site of the lesion, and duration of disease, were recorded. Histopathological examination was performed using Hematoxylin and Eosin (H&E) stain, with additional special stains like Ziehl-Neelsen and Periodic Acid-Schiff (PAS) applied where necessary.

Materials and Methods:
This investigation was conducted at the histology division of the Department of Pathology, MMIMSR, Mullana, between October 2022 and October 2023. The analysis included a total of 100 patients that had granulomatous lesions. Precise clinical information, such as age, gender, location of the lesion, and length of illness, was documented. The histological analysis was conducted using hematoxylin and eosin (H and E) stain, along with supplementary specific stains, such as Ziehl-Neelsen and periodic acid-Schiff (PAS) when needed.

Results:
Lesions of granulomatous nature were more common in individuals in their third and fourth decades of life, with a little higher occurrence in females (male: female ratio = 1:1.43). The primary location of infection was the gastrointestinal system, accounting for 16% of cases, followed by the urogenital tract at 15% and soft tissues at 13%. Granulomatous pathology-not otherwise specified (GP-NOS) was the most prevalent histological category, representing 52% of cases. It was followed by granulomatous pathology-tubercular (GP-TB) at 15%, granulomatous pathology-leprosy (GP-L) at 3%, and one case of granulomatous pathology-fungal (GP-F). The etiology of 25% of cases was attributed to tuberculosis, whereas in 3% of instances, it was diagnosed as leprosy. The main kind of neoplasms seen were epithelioid cell granulomas, with caseous necrosis being the most prevalent form of necrosis. About 10% of patients had fibrosis, and Langhans giant cells were often documented.

Conclusion:
Histopathology, with the use of certain stains, continues to be the most reliable method for identifying and classifying granulomatous lesions. Despite the broad use of Bacillus Calmette-Guerin (BCG) vaccine, infections, including tuberculosis (TB), remain the primary cause of granulomatous lesions in our community.
Calotropis procera: Network Pharmacology-based Virtual Screening and Molecular Mechanism Exploration against Hepatocellular Carcinoma
Authors: Pisal Harshad , Mahajan Amrita 
Published: December 2024

Abstract

BACKGROUND:
This study strategically investigates the antihepatocarcinogenic properties of Calotropis procera, also known as milkweed. Despite extensive literature on its ethnomedicinal uses and pharmacological activities, recent comprehensive analyses of its therapeutic potential and toxicity are lacking. This research utilizes network pharmacology, virtual screening, and molecular mechanism validation to explore its efficacy against hepatocellular carcinoma (HCC).

MATERIALS AND METHODS:
A network pharmacology-based approach was employed to identify active ingredients and elucidate potential molecular mechanisms of C. procera in HCC treatment. Techniques included active component screening, target prediction, gene ontology, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, complemented by molecular docking validation.

RESULTS:
The study identified 41 active constituents and 10 critical gene targets, including AKT1, TP53, tumor necrosis factor, BCL2, and EGFR. Network analysis revealed that C. procera influences tumor-associated signaling pathways, suggesting a promising preventive impact on hepatocellular carcinoma.

CONCLUSION:
The findings underscore the potential of C. procera as a natural therapeutic agent for HCC. By modulating key signaling pathways, it presents a dual approach to enhancing therapeutic efficacy while ensuring safety. This research lays the groundwork for future exploration of C. procera-derived compounds in pharmaceutical and biomedical contexts, opening avenues for innovative cancer treatment strategies.
Navigating healthcare leadership: Theories, challenges, and practical insights for the future
Authors: Singh PK , Singh S , Kumari V , Tiwari M 
Published: December 2024

ABSTRACT
Effective healthcare leadership is essential to ensure high-quality patient care and foster a supportive work environment for healthcare professionals. This review aims to consolidate existing healthcare leadership literature to provide evidence-based insights that can guide leadership development, improve team performance, and enhance patient care outcomes. A systematic search of academic databases such as PubMed, Scopus, Web of Science, CINAHL, Embase, and Google Scholar was performed using keywords related to healthcare leadership. Studies were selected based on their relevance, peer-reviewed status, and focus on healthcare settings. Thematic analysis was employed to synthesize findings from the selected studies. The review explores various leadership theories, including Great Man, trait, behavioral, transactional, transformational, and contingency theories, highlighting their relevance and application in healthcare. Effective healthcare leaders must possess traits such as vision, emotional intelligence, adaptability, and ethical integrity to navigate the complexities of modern healthcare. The review categorizes different leadership styles, including authoritarian, transformational, transactional, servant, and participative, and discusses their application in specific healthcare contexts. Leaders face challenges such as balancing personal and professional responsibilities, adapting to technological advancements, managing financial constraints, and ensuring regulatory compliance. Healthcare leadership requires a dynamic and adaptable approach that integrates various leadership theories and styles to address the unique challenges of the healthcare environment. This review underscores the importance of leadership development programs and calls for further research to explore the practical implementation of leadership strategies in diverse healthcare settings. The findings provide actionable insights for healthcare leaders to tailor their leadership styles to the specific needs of their teams and organizational contexts, ultimately enhancing patient care and operational efficiency.
A case of mesalamine potentiating hypoprothrombinemic effect of vitamin K antagonist (VKA) therapy resulting in life-threatening bleeding
Authors: Prabhu RS , Rahmathullah SN , Ahammad J 
Published: December 2024

ABSTRACT
A 76-year-old male patient, who underwent a post-aortic valve replacement with a mechanical valve in 2006, was on oral anticoagulant therapy with warfarin, maintaining a stable therapeutic level of anticoagulation until 2022. He had a new diagnosis of ulcerative colitis in 2022, following which he was started on mesalamine. He had been having a supratherapeutic level of anticoagulation, as evidenced by an international normalized ratio (INR) of 12 to 14 on multiple occasions since 2022, leading to gastrointestinal bleeding, necessitating multiple packed red cell transfusions. He presented to us in August 2024 with severe anemia due to gastrointestinal bleeding. The evaluation revealed severe depletion of vitamin K-dependent coagulation factors. In this report, we discuss the possible drug–drug interactions between mesalamine and vitamin K antagonists, which went unrecognized leading to life-threatening gastrointestinal bleeding.
Correlations of the expression of Cx43, SCFFBXW7, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues
Authors: Luan Rong-Gang , Liu Ming-Da , Deng Zi-Feng , Lu Cong-Lan , Yu Mei-Ling , Zhang Ming-Yu , Liu Rong , An Ran , Yao You-Liang , Guo Dong-Bei , Zhang Yong-Xing , Zhao Lei 
Published: December 2024

BACKGROUND
Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination. Conversely, reduced expression results in a loss of this capacity to facilitate cyclin E degradation. The ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein, with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical residues.
AIM
To investigate the correlation between expression of Cx43, SKP1/Cullin1/F-box (SCF)FBXW7, p-cyclin E1 (ser73, thr77, thr395) and clinicopathological indexes in colon cancer.
METHODS
Expression levels of Cx43, SCFFBXW7, p-cyclin E1 (ser73, thr77, thr395) in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their correlations.
RESULTS
Positive rate of Cx43, SCFFBXW7, p-cyclin E1(Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in detected samples were 76.32%, 76.32%, 65.79%, 5.26% and 55.26% respectively. Positive expressions of these proteins were not related to the tissue type, degree of tissue differentiation or lymph node metastasis. Cx43 and SCFFBXW7(r = 0.749), p-cyclin E1 (Ser73) (r = 0.667) and p-cyclin E1 (Thr395) (r = 0.457), SCFFBXW7 and p-cyclin E1 (Ser73) (r = 0.703) and p-cyclin E1 (Thr395) (0.415) were correlated in colon cancer (P < 0.05), and expressions of the above proteins were positively correlated in colon cancer.
CONCLUSION
Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7, thereby influencing the ubiquitination and degradation of cyclin E1.
High Joule heat as a risk factor for post-endoscopic submucosal dissection electrocoagulation syndrome: A multicenter prospective study
Authors: Ochi Masanori , Yamamoto Asaji , Suematsu Satoshi , Fukuda Keita , Morishige Kenjiro , Oka Yasuhiro , Ishikawa Yuta , Ueyama Shunsuke , Hiroshima Yoshinori , Omae Yoshio , Kusano Fumihiko , Kamoshida Toshiro 
Published: December 2024

BACKGROUND
Thermal damage may lead to inflammation of the peeled mucosal surface during endoscopic submucosal dissection (ESD).
AIM
To determine the effect of Joule heat on the onset of post-ESD electrocoagulation syndrome (PECS).
METHODS
In this prospective study, PECS was characterized by in-hospital fever (white blood cell count: ≥ 10000 μ/L or body temperature ≥ 37.5 °C) and abdominal pain (visual analog scale score ≥ 30 mm during hospitalization or increased by ≥ 20 mm from baseline at admission). High Joule heat was defined as 15390 J. Between April 2020 and April 2024, 209 patients underwent colorectal ESD; those with intraoperative perforation or penetration were excluded. The remaining 202 patients were divided into the PECS and non-PECS groups.
RESULTS
PECS occurred in 30 (14.9%) patients. Multivariate analysis revealed high Joule heat as an independent factor associated with PECS (odds ratio = 7.96; 95% confidence interval: 2.91-21.8, P < 0.01). The procedure time and presence of lesions in the right colon were not associated with PECS.
CONCLUSION
Accumulated thermal damage on the peeled mucosal surface should be considered during PECS onset. This thermal damage is likely a major component of the mechanism underlying PECS.
Continuous Domains for Function Spaces Using Spectral Compactification
Authors: Farjudian Amin , Jung Achim 
Published: December 2024

We introduce a continuous domain for function spaces over topological spaces which are not core-compact. Notable examples of such topological spaces include the real line with the upper limit topology, which is used in solution of initial value problems with temporal discretization, and various infinite dimensional Banach spaces which are ubiquitous in functional analysis and solution of partial differential equations. If a topological space $\mathbb{X}$ is not core-compact and $\mathbb{D}$ is a non-singleton bounded-complete domain, the function space $[\mathbb{X} \to \mathbb{D}]$ is not a continuous domain. To construct a continuous domain, we consider a spectral compactification $\mathbb{Y}$ of $\mathbb{X}$ and relate $[\mathbb{X} \to \mathbb{D}]$ with the continuous domain $[\mathbb{Y} \to \mathbb{D}]$ via a Galois connection. This allows us to perform computations in the native structure $[\mathbb{X} \to \mathbb{D}]$ while computable analysis is performed in the continuous domain $[\mathbb{Y} \to \mathbb{D}]$, with the left and right adjoints used for moving between the two function spaces.Comment: 19 pages, 1 figure, Mathematical Foundations of Programming Semantics (MFPS) 2024
How Digital Cats Tame Ideology: the Cat Content of Soviet Nostalgia as an Ideological Mediator
Authors: Tikhonova Sophia V. 
Published: December 2024

The article deals with the mechanics of broadcasting ideology through online user content, dedicated to domestic cats. The author believes that digital culture is changing the logic of the relationship between written and oral, long and short genres of objectification of ideology in mass consciousness. It ensures the presence of complex long ideological genres of Modernity in the media space, reinforcing it with a wide “protective belt” of microformats characteristic of entertainment content. The most typical type of the latter is cat content, which is understood as a form of social reflection that sets a cliched reaction to a media message through the image of a digital cat. The purpose of the article is to analyze the use of political ideologies in the context of Soviet nostalgia. The author examines the polar versions of the visualization of Soviet nostalgia in the context using the example of Vasya Lozhkin’s cats and the VK public “Cats for Communism”. The semantic multilayering of Vasya Lozhkin’s paintings is ensured by the fluidity and interchangeability of zoo- and anthropomorphic features of the characters and the ease of their ethical (de)evolution. The transition of cats to the red side is shown as a rather late phenomenon of digital culture, inscribed in the period of the last five years. Digital cats dearchaize communist ideology by associating it with digital fashion. In general, digital cats disassemble ideological narratives into micro-rhythms and creolize them, performing the function of a mediator forwarding the actualized old ideologies into the digital media space.
Let’s Practice Better... on Cats: Description and Visualisation of Artistic Images in Generative AI Models
Authors: Khandogin Ruslan , Proner Nina S. 
Published: December 2024

Artificial Intelligence (AI) plays an increasingly prominent role in various spheres of life in today’s world, including generation of a variety of visual content from selfie stream processing to creating works of digital art. The present paper raises the question of whether AI is capable of creating real art or it just imitates its external form. The paper examines the specificity of prompts: from concrete named ones to interpretive descriptive queries in linguistic, artistic and socio-cultural contexts. The article dwells upon some important aspects of evaluating the quality of keyword extraction algorithms and their relation to artistic practice. The authors rely on semiotic analysis to uncover encoded meanings and imports in the text. The article emphasises that the literary text is at the top of the hierarchy of cultural texts; it is characterised by intentionality and coherence and represents a complex semantic field where key words and images interact with the explicit and implicit contexts. The study examines and analyses the visualised images of Cheshire Cat, Cat Behemoth and Tomcat Murr created by the authors with the use of three generative neural networks: Stable Diffusion, Dall‑E and Kandinsky. Understanding and visualising the literary text by generative systems and models realising specific algorithms requires the ability to reveal its multilayered semantics and connection with the cultural context, which ultimately helps to understand the in-depth meanings of the work and its place in culture. Consideration of the operational quality of algorithms for keyword system extraction and image generation is deemed possible from the point of view of their structural organisation. Generative algorithms create an imitative reality, while the immanence of the artistic value determines the uniqueness and meanings of the created figurative world. The article can be useful to anyone interested in the substance and specificity of digital art, the relationship between technological innovations and socio-cultural context, the creation and visualisation of artistic images in generative AI models, their conceptualisation and interpretation.
Saving Pets: A Study of Online Mutual Aid Among Marginal Group During the China COVID-19 Quarantine Period
Authors: Shi Yu 
Published: December 2024

Under the forced and high-pressure situation of the epidemic lockdown, how did marginal groups use digital media to gather, expand and help each other? How do humans, animals and media work together? From the perspective of translation theory, this study examined the emergence and development of online pets mutual aid group in Guangzhou, China during the lockdown period of COVID‑19. This study found that digital media are not only translating other actors to become the organizational force of online pets mutual aid group but also translating themselves to promote the long-term development of the group. These two translations strengthen the resilience of the groups. Even if external pressures disappear, the spirit of mutual assistance and innovative mode of operation will continue because of continuous translation. Online pets mutual aid group challenge anthropocentrism. The group was a manifestation of the vitality of human, non-human or animal co‑interpretation and an extension of human tolerance and identification of non-human species.