bluuebunny/crossref_metadata_2025_split huggingface dataset:
EQ-5D-5L Slovenian population norms
Authors: Prevolnik Rupel Valentina , Ogorevc Marko 
Published: October 2020

Abstract
Background
The study aims to present Slovenian EQ-5D-5L population norms for different age and gender subgroups that can be used as reference values in future studies concerning health status. The secondary aim is to compare those norms with population norms from some other countries in Europe and elsewhere.

Methods
The cross-sectional survey was conducted between November 2019 and February 2020 via online panel. 1071 adults aged 18+ were included in the survey. The general population was sampled using quota sampling in terms of age, gender, and NUTS2 region. In the study, the EQ-5D-5L Slovenian online version was used. Descriptive statistics was used to present health status by age groups and genders for the EQ-5D-5L descriptive system, EQ VAS and the EQ-5D-5L index score. The latter was derived from Slovenian EQ-3D-3L tariff, transformed to five levels using the crosswalk methodology.

Results
The mean EQ VAS score in the Slovenian population was 79.9, mean utility index was 0.808. 28.2% of the population did not have problems on any dimension and 3.9% of the population had problems on all dimensions. Persons residing in Western Slovenia had, on average, 0.016 higher utility score, compared to Eastern Slovenia. Effect of gender was not significant. Age was negatively associated with both utility index and EQ VAS score. Education was positively correlated to health status. Problems on dimensions were generally increasing with age, except for anxiety/depression dimension, where youngest group (ages 18–29) reported more anxiety/depression compared to older counterparts. Self-reported anxiety/depression was more pronounced in women.

Conclusions
Similarly to other countries, the health generally deteriorates with age, except for the anxiety/depression dimension where the share of respondents reporting no problems was lowest in the youngest age group. The open question for the future remains, whether population norms from this online sample differ significantly from the actual EQ-5D-5L health status data of the Slovenian general population.
Persian version of the brief Older People’s Quality of Life questionnaire (OPQOL-brief): the evaluation of the psychometric properties
Authors: Feizi Awat , Heidari Zahra 
Published: October 2020

Abstract
Background and objective
Quality of life (QoL) is a multi-dimensional concept and its assessment is one of important themes of care for older people. Assessing QoL in older people needs specific scales. The aim of this study was to culturally adapt and investigate the psychometric properties of the Persian version of brief Older People’s Quality of Life questionnaire (OPQOL-brief) in an Iranian older population.

Methods
This methodological cross-sectional study was conducted among 525 Persian-speaking older people (aged 60 and over), living in Isfahan, Iran. Translation of the OPQOL-brief questionnaire was performed using forward–backward method. Test–retest reliability was evaluated through Intra Class Correlation (ICC) coefficient and internal consistency by using Cronbach’s α. Construct validity was investigated by using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and Latent class analysis (LCA). Criterion, convergent and discriminant validities were also assessed.

Results
Persian version of the OPQOL-brief showed good test–retest reliability (ICC = 0.842, 95% CI = 0.73–0.91; P < 0.001). Persian OPQOL-brief scale demonstrated high internal consistency (Cronbach’s α = 0.83). It showed good discriminant validity and differentiated old patients from healthy older individuals (P < 0.001). Construct validity based on EFA led to extraction of three dimensions (“socioeconomic”, “emotional”, and “physical” well-being) and the CFA confirmed the adequacy of extracted construct from EFA (CFI = 0.909, PCFI = 0.52, PNFI = 0.5, CMIN/DF = 3.012, and RMSEA = 0.08). LCA classified participants into three classes in terms of QoL level (low (16%), middle (67%), and high (17%)). Criterion validity and convergent validity revealed significant positive correlations between OPQOL-brief and physical and psychological dimensions of the SF-36.

Conclusion
The Persian version of the OPQOL-brief is a reliable and valid instrument for assessing QoL with applicability in a broad range of older Persian language population.
Recruiting migrant workers in Australia for Public Health surveys: how sampling strategy make a difference in estimates of workplace hazards
Authors: Daly Alison , Reid Alison 
Published: October 2020

Abstract
Objectives
One third of the Australian work force are immigrants. Relatively little is known about working conditions for specific migrant groups. The objectives of this paper are to describe and compare the sampling strategies used to recruit migrant workers from specific migrant groups working in Australia into a cross-sectional study designed to produce population estimates of workplace hazards and self-reported health.

Results
Two cross sectional telephone surveys were conducted with immigrants currently working in Australia. Survey 1 used quota sampling from lists provided by a sample broker. Survey 2 used a combination of probability and non-probability sampling, including random sampling from telephone lists. Data from the surveys were weighted and comparisons made with unweighted data. While weighting adjusted for most differences across the sample sources, the likelihood of exposure to workplace hazards depended on exposure types and sampling strategies. We concluded that by using a combination of sampling strategies it is possible to recruit immigrants from specific migrant groups and provide a balanced view of working conditions, although no one strategy was best for all types of measures. Access to a robust sample source for migrants would enable a better perspective to migrant populations’ working conditions.
Anemonefish, a model for Eco-Evo-Devo
Authors: Roux Natacha , Salis Pauline , Lee Shu-Hua , Besseau Laurence , Laudet Vincent 
Published: October 2020

AbstractAnemonefish, are a group of about 30 species of damselfish (Pomacentridae) that have long aroused the interest of coral reef fish ecologists. Combining a series of original biological traits and practical features in their breeding that are described in this paper, anemonefish are now emerging as an experimental system of interest for developmental biology, ecology and evolutionary sciences. They are small sized and relatively easy to breed in specific husbandries, unlike the large-sized marine fish used for aquaculture. Because they live in highly structured social groups in sea anemones, anemonefish allow addressing a series of relevant scientific questions such as the social control of growth and sex change, the mechanisms controlling symbiosis, the establishment and variation of complex color patterns, and the regulation of aging. Combined with the use of behavioral experiments, that can be performed in the lab or directly in the wild, as well as functional genetics and genomics, anemonefish provide an attractive experimental system for Eco-Evo-Devo.
Description of a fossil camelid from the Pleistocene of Argentina, and a cladistic analysis of the Camelinae
Authors: Lynch Sinéad , Sánchez-Villagra Marcelo R. , Balcarcel Ana 
Published: October 2020

AbstractWe describe a well-preserved South American Lamini partial skeleton (PIMUZ A/V 4165) from the Ensenadan (~ 1.95–1.77 to 0.4 Mya) of Argentina. The specimen is comprised of a nearly complete skull and mandible with full tooth rows, multiple elements of anterior and posterior limbs, and a scapula. We tested this specimen’s phylogenetic position and hypothesized it to be more closely related to Lama guanicoe and Vicugna vicugna than to Hemiauchenia paradoxa. We formulate a hypothesis for the placement of PIMUZ A/V 4165 within Camelinae in a cladistic analysis based on craniomandibular and dental characters and propose that future systematic studies consider this specimen as representing a new species. For the first time in a morphological phylogeny, we code terminal taxa at the species level for the following genera: Camelops, Aepycamelus, Pleiolama, Procamelus, and Alforjas. Our results indicate a divergence between Lamini and Camelini predating the Barstovian (16 Mya). Camelops appears as monophyletic within the Camelini. Alforjas taylori falls out as a basal member of Camelinae—neither as a Lamini nor Camelini. Pleiolama is polyphyletic, with Pleiolama vera as a basal Lamini and Pleiolama mckennai in a more nested position within the Lamini. Aepycamelus and Procamelus are respectively polyphyletic and paraphyletic. Together, they are part of a group of North American Lamini from the Miocene epoch.
Towards integrated surveillance-response systems for the prevention of future pandemics
Authors: Zinsstag Jakob , Utzinger Jürg , Probst-Hensch Nicole , Shan Lv , Zhou Xiao-Nong 
Published: October 2020

AbstractMost human pathogens originate from non-human hosts and certain pathogens persist in animal reservoirs. The transmission of such pathogens to humans may lead to self-sustaining chains of transmission. These pathogens represent the highest risk for future pandemics. For their prevention, the transmission over the species barrier — although rare — should, by all means, be avoided. In the current COVID-19 pandemic, surprisingly though, most of the current research concentrates on the control by drugs and vaccines, while comparatively little scientific inquiry focuses on future prevention. Already in 2012, the World Bank recommended to engage in a systemic One Health approach for zoonoses control, considering integrated surveillance-response and control of human and animal diseases for primarily economic reasons. First examples, like integrated West Nile virus surveillance in mosquitos, wild birds, horses and humans in Italy show evidence of financial savings from a closer cooperation of human and animal health sectors. Provided a zoonotic origin can be ascertained for the COVID-19 pandemic, integrated wildlife, domestic animal and humans disease surveillance-response may contribute to prevent future outbreaks. In conclusion, the earlier a zoonotic pathogen can be detected in the environment, in wildlife or in domestic animals; and the better human, animal and environmental surveillance communicate with each other to prevent an outbreak, the lower are the cumulative costs.
Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD
Authors: Wang Shaoteng , Tatman Micaela , Monteiro Mervyn J. 
Published: October 2020

AbstractMissense mutations in UBQLN2 cause X-linked dominant inheritance of amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). UBQLN2 belongs to a family of four highly homologous proteins expressed in humans that play diverse roles in maintaining proteostasis, but whether one isoform can substitute for another is not known. Here, we tested whether overexpression of UBQLN1 can alleviate disease in the P497S UBQLN2 mouse model of ALS/FTD by crossing transgenic (Tg) mouse lines expressing the two proteins and characterizing the resulting genotypes using a battery of pathologic and behavioral tests. The pathologic findings revealed UBQLN1 overexpression dramatically reduced the burden of UBQLN2 inclusions, neuronal loss and disturbances in proteostasis in double Tg mice compared to single P497S Tg mice. The beneficial effects of UBQLN1 overexpression were primarily confirmed by behavioral improvements seen in rotarod performance and grip strength in male, but not female mice. Paradoxically, although UBQLN1 overexpression reduced pathologic signatures of disease in P497S Tg mice, female mice had larger percentage of body weight loss than males, and this correlated with a corresponding lack of behavioral improvements in the females. These findings lead us to speculate that methods to upregulate UBQLN1 expression may reduce pathogenicity caused by UBQLN2 mutations, but may also lead to gender-specific outcomes that will have to be carefully weighed with the therapeutic benefits of UBQLN1 upregulation.
Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia Treated With Ibrutinib: Development and Validation of a Four-Factor Prognostic Model
Authors: Ahn Inhye E. , Tian Xin , Ipe David , Cheng Mei , Albitar Maher , Tsao L. Claire , Zhang Lei , Ma Wanlong , Herman Sarah E. M. , Gaglione Erika M. , Soto Susan , Dean James P. , Wiestner Adrian 
Published: October 2020

PURPOSE Randomized trials established the superiority of ibrutinib-based therapy over chemoimmunotherapy in chronic lymphocytic leukemia. Durability of progression-free survival (PFS) with ibrutinib can vary by patient subgroup. Clinical tools for prognostication and risk-stratification are needed. PATIENTS AND METHODS Patients treated with ibrutinib in phase II and III trials provided the discovery data set and were subdivided into discovery and internal validation cohorts. An external validation cohort included 84 patients enrolled in our investigator-initiated phase II trial. Univariable analysis of 18 pretreatment parameters was performed using PFS and overall survival (OS) end-points. Multivariable analysis and machine-learning algorithms identified four factors for a prognostic model that was validated in internal and external cohorts. RESULTS Factors independently associated with inferior PFS and OS were as follows: TP53 aberration, prior treatment, β-2 microglobulin ≥ 5 mg/L, and lactate dehydrogenase > 250 U/L. Each of these four factors contributed one point to a prognostic model that stratified patients into three risk groups: three to four points, high risk; two points, intermediate risk; zero to one point, low risk. The 3-year PFS rates for all 804 patients combined were 47%, 74%, and 87% for the high-, the intermediate-, and the low-risk group, respectively ( P < .0001). The 3-year OS rates were 63%, 83%, and 93%, respectively ( P < .0001). The model remained significant when applied to treatment-naïve and relapsed/refractory cohorts individually. For 84 patients in the external cohort, BTK and PLCG2 mutations were tested cross-sectionally and at progression. The cumulative incidences of mutations were strongly correlated with the model. In the external cohort, Richter’s transformation occurred in 17% of the high-risk group, and in no patient in the low-risk group. CONCLUSION Patients at increased risk of ibrutinib failure can be identified at treatment initiation and considered for clinical trials.
Exploring the Experiences of Patients in the Oncology Care Model
Authors: Franklin Elizabeth F. , Nichols Helen M. , Bohannon Linda 
Published: October 2020

PURPOSE: The Oncology Care Model (OCM) was developed to improve care while also supporting patient-centered practices. This model could significantly affect experiences of patients with cancer; however, previous studies have not explored patient perspectives. PATIENTS AND METHODS: This cross-sectional study used focus group and survey methodology to explore patient experiences in the OCM. The sample included 213 patients (OCM patients, n = 130 recruited within OCM practices; non-OCM patients, n = 83 recruited via e-mail from the Cancer Support Community Cancer Experience Registry). RESULTS: Findings suggest that patients in OCM practices were more likely to report that their cancer care team asked about social/emotional distress or concerns and more likely to have social/emotional resources offered. OCM patients were also more likely to have discussed advance directives with providers. They were also more likely to be satisfied with provider explanations of treatment benefits as well as treatment risks and adverse effects. Lastly, OCM patients were significantly more satisfied with discussion of treatment costs and provided higher ratings of preparation by their cancer care team for management of adverse effects. CONCLUSION: Patients in this study reported experiences consistent with many of the key goals of the OCM. This is promising and may indicate the need to expand the model. However, because of the potential selection bias of our sampling method, more research is needed.
Enhancement of the Activity for the Oxygen Reduction Reaction on Well-defined Single Crystal Electrodes of Pt by Hydrophobic Species
Authors: Hoshi Nagahiro , Nakamura Masashi 
Published: October 2020

Abstract
The activity for the oxygen reduction reaction (ORR), which is the reaction at the air electrode of fuel cells, depends on the surface structure of the electrode markedly. This review summarizes the effects of hydrophobic species on the activity for the ORR on single crystal electrodes of Pt. We have examined the effects of aliphatic and aromatic molecules on the ORR. Structural effects on the increase of the activity and the factors of the enhancement are discussed.
Development of a Vibrating Pendant-drop Raman Spectrometer and Polarization of Cavity Enhanced Raman Scattered Light
Authors: Inoue Tomonao , Kohno Jun-ya 
Published: October 2020

Abstract
We developed a pendant-drop Raman spectrometer and observed cavity enhanced Raman scattered light. Further enhancement of the Raman scattered light was demonstrated by controlling the droplet shape, which was performed by applying vibrations to the pendant drop. We found that (1) stimulated Raman scattering proceeds and enhances its intensity at the surface of the pendant droplet, (2) a horizontally elongated droplet gives further enhancement by light confinement, and (3) only s-polarized light resonates in the pendant drop. This study facilitates spectroscopic studies on the liquid surface.
Preserve and spread of traditional plant varieties
Authors: Molla M. 
Published: October 2020

The seeds of the traditional varieties which we have inherited from our ancestors thousands of years ago are vanishing in our days and with them we are losing our connection with them and the biodiversity. In this eTwinning project teachers and students aimed at becoming an ark with the mission to protect and save these seeds. We started our quest by making our questionnaire which was simple since it consisted of three questions but would ultimately tell the story of how the traditional seeds were inherited to us. Students researched within their family and neighborhood context. The findings of their research showed that only about 10% of the students found seeds of traditional vegetable varieties. Subsequently we tried to multiply these seeds by cultivating them and spreading them to our school and our community.
In vitro efficacy of a copper iodine complex PPE disinfectant for SARS-CoV-2 inactivation
Authors: Mantlo Emily , Rhodes Tanya , Boutros Jenny , Patterson-Fortin Laura , Evans Alex , Paessler Slobodan 
Published: October 2020

Background: The ability to protect workers and healthcare professionals from infection by SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is of great concern. Hospitals, nursing homes and employers are adopting infection control strategies based on guidance from leading public health organizations such as the CDC, OSHA, FDA, and other government bodies. Certain hard surface disinfectants are effective against SARS-CoV-2 but are not suitable for use on skin or personal protective equipment (PPE) that comes into contact with skin. Furthermore, near-ubiquitous alcohol-based hand sanitizers are acceptable for use on skin, but they are not suitable for use on PPE. PPE, especially masks, are also commonly being used for longer durations than normal. There is a need for new products and techniques that can effectively disinfect PPE during wear time without having detrimental effects on surrounding skin. Clyraguard spray is a novel copper iodine complex designed to be used on non-critical PPE. Methods: In this study, the Clyraguard copper iodine complex was tested for its ability to inactivate SARS-CoV-2 in solution. Results: These data indicate the product to be effective in reducing SARS-CoV-2 titers in a time-dependent manner, with the virus being reduced below the detection limits within 30 minutes. Conclusions: These results suggest that Clyraguard may be an effective tool for mitigating cross-contamination of non-critical PPE that may come into contact with SARS-CoV-2.
Electronic Trace Data and Legal Outcomes: The Effect of Electronic Medical Records on Malpractice Claim Resolution Time
Authors: Ransbotham Sam , Overby Eric M. , Jernigan Michael C. 
Published: October 2020

Information systems generate copious trace data about what individuals do and when they do it. Trace data may affect the resolution of lawsuits by, for example, changing the time needed for legal discovery. Trace data might speed resolution by clarifying what events happened when, or they might slow resolution by generating volumes of new and potentially irrelevant data that must be analyzed. To investigate this, we analyze the effect of electronic medical records (EMRs) on malpractice claim resolution time. Use of EMRs within hospitals at the time of the alleged malpractice is associated with a four-month (12%) reduction in resolution time. Because unresolved malpractice claims impose substantial costs on the entire healthcare system, our finding that EMRs are associated with faster resolution has broad welfare implications. Furthermore, as we increasingly digitize society, the ramifications of trace data on legal outcomes matter beyond the medical context. This paper was accepted by Teck Ho, information systems.
Asymmetric Reporting Timeliness and Informational Feedback
Authors: Chen Qi , Huang Zeqiong , Jiang Xu , Zhang Gaoqing , Zhang Yun 
Published: October 2020

We examine the effects of asymmetric timeliness in reporting good versus bad news on price informativeness when prices provide useful information to assist firms’ investment decisions. We find that a reporting system featuring more timely disclosure of bad news than of good news encourages speculators to trade on their private information. Consequently, it generates a higher expected investment level and firm value. Our analysis generates predictions consistent with empirical findings and provides a justification for the more timely reporting of bad news in the absence of managerial incentive problems.This paper was accepted by Brian Bushee, accounting.
Comparison of growth structures for continuous-wave electrically pumped 1.55 μm quantum dash lasers grown on (001) Si
Authors: Luo Wei , Xue Ying , Huang Jie , Lin Liying , Shi Bei , Lau Kei May 
Published: October 2020

Semiconductor lasers directly grown on silicon offer great potential as critical components in high-volume, low-cost integrated silicon photonics circuits. Although InAs/InP quantum dash (QDash) lasers on native InP substrate emitting at 1.5 μm (C-band) have demonstrated notable performance, the growth of InAs/InP QDash lasers on silicon remains undeveloped because of the 8% lattice mismatch between InP and silicon. Here we report advances of growth techniques leading to the first C-band room-temperature continuous-wave electrically pumped QDash lasers on CMOS standard (001) silicon substrates by metalorganic chemical vapor deposition. A correlation between various material characterizations and device performance is analyzed for different QDash laser structures grown on planar nominal (001) silicon. With the optimized QDash growth and improved fabrication process, the lowest threshold current density of

1.5

kA
/

cm
2

was determined on an

8

μm
×
1.5

mm

device on planar silicon with a single facet output power exceeding 14 mW. The device results illustrate the good material quality of the QDash lasers grown on silicon, suggesting potential applications for other active components of photonic integrated circuits, such as semiconductor optical amplifiers, modulators, and photodetectors.