bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative assessment of cardiovascular autonomic impairment in cancer survivors: a single center case series
Authors: Noor Benjamin , Akhavan Shannel , Leuchter Michael , Yang Eric H. , Ajijola Olujimi A. 
Published: July 2020

Abstract
Background
Cardiovascular autonomic dysfunction in cancer survivors is poorly understood.

Objectives
To better characterize the clinical characteristics and types of autonomic dysfunction in this population.

Methods
A retrospective analysis of cancer survivors within an academic cardio-oncology program referred for suspected autonomic dysfunction was performed. Autonomic reflex testing of adrenergic, cardiovagal, and sudomotor function was done. Autonomic impairment was graded on severity based on the Composite Autonomic Severity Score system. Patients with pre-existing autonomic dysfunction prior to their cancer diagnosis were excluded.

Results
Of approximately 282 total patients in the UCLA Cardio-Oncology program, 24 were referred for suspected autonomic dysfunction and met the inclusion criteria. 22 had autonomic impairment on autonomic reflex testing. Eight patients were female, and the mean age at time of autonomic testing was 51.3 years. The average duration from cancer diagnosis to autonomic testing was 10.3 years. The reasons for referral included dizziness, tachycardia, palpitations, and syncope. The majority of patients (75%) had hematologic disorders. The most common chemotherapies administered were vinca alkaloids (54.2%), alkylating agents (66.7%), and anthracyclines (54.2%). Most patients received radiation to the thorax (66.7%) and neck (53.3%). Eleven patients had mild autonomic impairment, 7 had moderate, and 4 had severe autonomic impairment. Dysfunction was commonly present in the sympathetic and parasympathetic branches, but most pronounced in the sympathetic system. The majority of patients were diagnosed with orthostatic hypotension (50%), inappropriate sinus tachycardia (20.8%), and postural orthostatic tachycardia syndrome (12.5%) and had subjective improvement with treatment.

Conclusion
Cardiovascular autonomic dysfunction occurs in cancer survivors, and commonly affects both the sympathetic and parasympathetic systems. Symptom recognition in patients should prompt autonomic testing and treatment where appropriate.
Re-emergence of the Glossy Ibis (Plegadis falcinellus) in inland South Korea
Authors: Lee Sang-Yeon , Sung Ha-Cheol , Han Donguk , Cha Jin-Yeol 
Published: July 2020

AbstractGlossy Ibis (Plegadis falcinellus), which has never been recorded in South Korea, appeared on Jeju Island in 2018 and re-emerged in the inland area of Seocheon-gun (South Chungcheong Province) and in Goyang-si (Gyeonggi Province) in the following year. This study aims to report the progress in observingP.falcinellusin the inland areas of South Korea in 2019 and to predict its origin region and future propensity for habitats in the country through literature review. On 5 May 2019, an individual ofP.falcinelluswith breeding feathers was observed in a farmland in Wolsan-ri, Seocheon-gun. Twelve days later, another one was identified in a farmland in Janghang-dong, Goyang-si, about 173 km north of Wolsan-ri. The observed birds fed and rested in the area and stayed for only a day. The individual birds spotted in South Korea in 2019 are conjectured to have come from either Southeast Asia or Australia, among areas located in East Asian-Australasian Flyway (EAAF). This is becauseP.falcinellus, a species with excellent dispersal capacity, forms a population in new areas during extreme environmental changes in their current habitats, especially droughts. For 2 years,P.falcinelluswas observed to be migrating in spring; however, in the future, they may exhibit the same propensity for breeding and habitats as that of birds migrating in autumn. As it is a conspicuous species, effective detection of their arrival requires a survey system that classifies the country by habitat type and involves periodic and multiple observations by experts and citizens.
Effect of entomopathogenic fungi against invasive pest Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) in maize
Authors: B. Ramanujam , B. Poornesha , A. N. Shylesha 
Published: July 2020

AbstractTen indigenous entomofungal strains ofBeauveria bassiana,Metarhizium anisopliae, andM. rileyiwere evaluated against 2nd instar larvae of the maize fall armyworm (FAW)Spodptera frugiperda(J. E. Smith) (Lepidoptera: Noctuidae) in a laboratory bioassay. Among the ten strains tested,M. anisopliaeICAR-NBAIR Ma-35 caused 67.8% mortality, followed byB. bassianaICAR-NBAIR Bb-45 with 64.3%, and ICAR-NBAIR Bb-11 with 57.1% mortality. Rest of the isolates showed 10.7–28.6% mortality. ICAR-NBAIR Ma-35 showed LC50of 1.1 × 107spores/ml and LT50at 1 × 108spores/ml is 86.04 h and ICAR-NBAIR Bb-45 showed LC50of 1.9 × 107spores/ml and LT50at 1 × 108spores/ml is 88.30 h. Field evaluation with these two promising strains were conducted against maize fall armyworm for 2 years (2018 and 2019) at ICAR-National Bureau of Agricultural Insect Resources experimental farm, Bengaluru, Karnataka, India. Field trial results indicated 68 and 69% reduction of FAW infestation and 55 and 62% increase in yield in the plots treated withM. anisopliaeICAR-NBAIR Ma-35/B. bassianaICAR-NBAIR Bb-45, respectively, during 2018. In 2019, 70 and 76% reduction of FAW infestation and 44 and 55% increase in yield were observed in the plots treated with these two entomofungal pathogens, respectively.
The role of hepatic transcription factor cAMP response element-binding protein (CREB) during the development of experimental nonalcoholic fatty liver: a biochemical and histomorphometric study
Authors: Awaad Ashraf K. , Kamel Maher A. , Mohamed Magdy M. , Helmy Madiha H. , Youssef Magda I. , Zaki Eiman I. , Essawy Marwa M. , Hegazy Marwa G. A. 
Published: July 2020

Abstract
Background
Several molecular mechanisms contribute to the initiation and progression of nonalcoholic fatty liver disease (NAFLD); however, the exact mechanism is not completely understood. Cyclic adenosine monophosphate (cAMP) is one of the most promising pathways that regulates various cellular functions including lipid and carbohydrate metabolism. cAMP induces gene transcription through phosphorylation of the transcription factor, cAMP response element-binding protein (CREB). The action of cAMP is tightly regulated by its level and repression. Among the repressors, Inducible cAMP Early Repressor (ICER) is the only inducible CRE-binding protein. The present study aimed to evaluate the role of hepatic CREB level in the development of experimental NAFLD model to clarify the pathogenesis of the disease. NAFLD 35 male Wistar rats fed a high fat diet for a period of 14 weeks were studied compared with 35 control rats fed a standard diet. Five fasting rats were sacrificed each 2 weeks intervals for a period of 14 weeks.

Results
NAFLD group revealed a remarkable duration—dependent elevation in cAMP and CREB levels in the liver tissue compared to control group (P value < 0.004, P value < 0.006, respectively). In contrast, ICER gene expression, as a dominant-negative regulator of CREB, was downregulated in the liver of NAFLD group compared to control group. We also demonstrated that CREB levels were positively correlated with liver function tests, and glucose homeostasis parameters.

Conclusions
Our results indicate that cAMP/CREB pathway provides an early signal in the progression to NAFLD representing a noninvasive biomarker that can early detect NAFLD and a promising therapeutic target for the treatment of the disease as well.
Short Stature is Progressive in Patients with Heterozygous NPR2 Mutations
Authors: Hanley Patrick C , Kanwar Harsh S , Martineau Corine , Levine Michael A 
Published: July 2020

Abstract

Background
NPR2 encodes atrial natriuretic peptide receptor B (ANPRB), a regulator of skeletal growth. Biallelic loss-of-function mutations in NPR2 result in acromesomelic dysplasia Maroteaux type (AMDM; OMIM 602875), while heterozygous mutations may account for 2% to 6% of idiopathic short stature (ISS).

Objective
Describe the physical proportions and growth characteristics of an extended family with novel NPR2 mutations including members with AMDM, ISS, or normal stature.

Design and Participants
We performed whole exome sequencing in 2 healthy parents and 2 children with AMDM. Detailed genotyping and phenotyping were performed on members of a multigenerational family in an academic medical center. We expressed mutant proteins in mammalian cells and characterized expression and function.

Results
The sisters with AMDM were compound heterozygotes for missense mutations in the NPR2 gene, a novel p.P93S (maternal) and the previously reported p.R989L (paternal). Both mutant ANPRB proteins were normally expressed in HEK293T cells and exhibited dominant negative effects on wild-type ANPRB catalytic activity. Heterozygous relatives had proportionate short stature (height z-scores −2.06 ± 0.97, median ± SD) compared with their wild-type siblings (−1.37 ± 0.59). Height z-scores progressively and significantly decreased as NPR2-heterozygous children matured, while remaining constant in their wild-type siblings.

Conclusions
Biallelic NPR2 mutations cause severe skeletal dysplasia (AMDM), whereas heterozygous mutations lead to a subtler phenotype characterized by progressive short stature with by increasing loss of height potential with age.
The Challenge of Minority Nationalism
Authors: Heuman Johannes 
Published: July 2020

Abstract
This article investigates how the French antiracist movement and its main organizations dealt with Zionism and the Middle East conflict from the liberation of France until the early 1970s. Their generally positive view of Israel and their concern for Arab interests at the end of the 1940s demonstrate these republican organizations' desire to recognize ethnic identities. During the 1950s an ideological split between left-wing antiracism and Zionism began to develop, and by the end of the 1960s a number of new antiracist associations questioned the very foundation of the Jewish state. Overall, the study argues that antiracist organizations' stances on and statements about Zionism and the Middle East conflict influenced Jewish-Arab relations during the postwar period and played an important role for both Jews and Arabs.
Cet article examine comment le mouvement antiraciste français et ses principales organisations ont abordé le sionisme et le conflit au Moyen-Orient depuis la Libération jusqu'au début des années 1970. Leur opinion surtout positive d'Israël ainsi qu'un souci pour les intérêts arabes à la fin des années 1940 montrent un certain désir par ces organisations républicaines de reconnaître les identités ethniques. Pendant les années 1950, une fracture idéologique entre l'antiracisme de gauche et le sionisme commence à se développer, et dès la fin des années 1960 un activisme plus poussé a amené de nouvelles associations antiracistes à remettre en question les fondements mêmes de l'Etat juif. Dans l'ensemble, l'étude montre que les organisations antiracistes ont été impliquées dans l'élaboration des relations judéo-arabes après la guerre à travers leurs positions et déclarations sur le sionisme et le Moyen-Orient, des questions qui jouent un rôle important pour les Juifs et les Arabes.
crianças e música: educação musical e estudos da infância em diálogo
Authors: Cunha Sandra Mara da 
Published: July 2020

Children and music are the theme of this article conceived as a sort of rehearsal, with the aim of thinking a musical education of childhood. Its theoretical foundations emerge from conversations between music education and childhood studies, and formed the basis for the lecture workshop held at the II Congress of Childhood Studies, in September 2019, at the University of the State of Rio de Janeiro. The text addresses methodological openings present in creative approaches to curricula based on network formats and circles. Improvisations and compositions made by children and guided by professor-artists who know their craft, emerge from these experimental dynamics. The participation of children in collaborative action with their teachers gives, in turn, new meanings to the teacher’s role in the form of “double listening”—listening both to children and to their musical expressions. The development of research in children’s music has powerful implications both for musical education and for the field of education. This research also contributes to childhood studies, since listening to children's musical expressions makes it possible to know more about what they think, feel and do when they create their music. It also promises to result in greater visibility and audibility for the songs invented by them, and for the recognition of the importance of music education in schools.
crianças e guerra: as balas perdidas!
Authors: Abramowicz Anete 
Published: July 2020

This essay seeks to answer the questions of which children in the contemporary world have been targeted and killed "unintentionally”or "at random" by the Brazilian State. In order to understand the place of children in this “war” we rely on the work, among others, of Achille Mbembe, Maurizio Lazzarato and Peter Pál Pelbart. Our text is structured in six sections. First, we take up the concepts of biopolitics, biopower and necropolitics , in an attempt to specify the type of governmental power that is exercised nowadays. Biopower is understood, not only as a military or political concept, but also in relation to a “biological” war (Lazzarato, 2016) against blacks, against certain sexualities, against some women and against some children. We than show how the construction of the universal idea of “child” excludes children who do not belong to this representation, which is, in general, disseminated as being the only image of a child. This diffusion of a single, universal notion of “child” is made through countless discursive and audiovisual imagery, and excludes black children and all those who diverge from or “flee” the hegemonic way of representing, thinking and writing about what a child is. Finally, we verify that the dead children are black and poor and we demonstrate the importance of children's political participation in social life.
infância, cultura visual e educação
Authors: Fernandes Adriana Hoffmann , Cassino Helenice Mirabelli 
Published: July 2020

This article combines thoughts about childhood, visual culture and education. It is known that we live among multiple images that shape the way we see our reality, and researchers in the visual culture field investigate how this role is played out in our culture. The goal is to make some applications those ideas, to think about the relationship between the images and education. This article tries to grasp what visual culture is and in what ways presumptions about childhood generate and are generated by this association. It also discusses the genesis of these presumptions and the images they generate through a philosophical approach, questioning the role of education in a culture tied to the media, and about how children, who are familiar with multiple screens, presage a new visual literacy. We see how images play a fundamental role in the way children give meaning to the world around them and to themselves, in the context of their local culture. Given this context, it is necessary to consider how visual culture is tied to the elementary school, and what challenges confront the generation of wider and more creative ways to approach visual framing in children’s education.
lipman e a filosofia para crianças: cultivo “do” pensamento ou cultivo de “um” pensamento?
Authors: Pereira Diego Bertolo , Paiva Wilson Alves de 
Published: July 2020

This text aims to perform a “fly over” the Philosophy for Children program--created by the philosopher and educator Matthew Lipman-–in order to identify certain philosophical problems that might appear there, one of them being the issue of universality. In response to Lipman’s claims of universality, we try to uncover his underlying ideological position that informs his approach to the concept. To achieve that goal, we return to the program’s beginnings, in order to ask how the idea of Philosophy for Children appeared and how it has developed up to the present moment. We argue that Lipman’s novel proposal to think philosophically with children emerged, in part, as a response to the student movements of 1968--a response, that is, to a specific political context that was marked by strong social and ideological disputes. Finally, we make a comparative analysis of the social and political context that informs Latin American Philosophy, and the extent to which it, also, has been shaped by a pragmatic response to a particular historical moment. The difference between the Anglo-American and the Latin American contexts is here characterized as an obstacle to a certain “universal” logos to which the Lipmanian project is linked. Our analysis is aided by the Discourse of marginalization and barbarism, produced by the Mexican philosopher Leopoldo Zea.
Gastric Microbiota in a Low–Helicobacter pylori Prevalence General Population and Their Associations With Gastric Lesions
Authors: Ndegwa Nelson , Ploner Alexander , Andersson Anders F. , Zagai Ulrika , Andreasson Anna , Vieth Michael , Talley Nicholas J. , Agreus Lars , Ye Weimin 
Published: July 2020

INTRODUCTION:
Non–Helicobacter pylori microbiota might account for some cases with unexplained chronic gastritis that may in a minority eventually progress to gastric cancer through the Correa cascade. We characterized gastric microbiota by describing the normal stomach, compared it with early precancerous lesions and other disease states, and assessed whether H. pylori status affects bacterial diversity.

METHODS:
In a population-based study of those with and without gastrointestinal symptoms, cytology brush samples were collected during endoscopy from 316 individuals. Mucosal status was classified as normal mucosa (171), nonatrophic H. pylori gastritis (33), atrophic gastritis (12), or antral chemical gastritis (61). The 16S rRNA gene sequencing and analysis were performed to characterize the microbiota.

RESULTS:
Microbiota in atrophic gastritis and nonatrophic H. pylori gastritis stomachs were dysbiotic and differed from those in the normal stomach (P = 0.001). The normal stomach had the highest microbial diversity, followed by antral chemical gastritis. The atrophic gastritis and chronic H. pylori gastritis groups had the lowest diversity, a difference that was statistically significant (P = 0.01). Besides H. pylori, non–H. pylori bacteria accounted for group differences. Microbial network analysis showed that the normal group network was most highly connected, whereas the H. pylori gastritis group had the lowest connection. We found an increasing positive co-occurrence of oral bacteria in the stomach because samples deviated from the normal network, some of which were pathogens. The H. pylori–negative group had the highest microbial diversity (Shannon index) compared with the H. pylori–positive group (P = 0.001).

DISCUSSION:
In this low–H. pylori prevalence general population, the gastric mucosal microbiota of the normal stomach differed significantly from those with nonatrophic or atrophic gastritis. There was an increasing abundance of pathogenic bacteria from the normal state to early precancerous states.
Donald J. Trump and the Rhetoric of White Ambivalence
Authors: Kelly Casey Ryan 
Published: July 2020

Abstract
This essay examines how President Trump’s vacillations between overt and colorblind racism represent the intensification of white racial anxieties in anticipation of an impending demographic shift toward a nonwhite majority. Trump’s contradictory rhetoric on race becomes legible in the context of white ambivalence, a condition that entails that white identity, history, and culture be respected as morally superior but, at the same time, not be characterized as white supremacy. Examining a selection of Trump’s campaign and postelection rallies, I show how white ambivalence constitutes a perverse mixture of overweening and explicit valorizations of people of color and, simultaneously, a forceful disavowal of racial conversations that might otherwise implicate white identity in the legacy of white supremacy.
Theistnormativity and the Negation of American Atheists in Presidential Inaugural Addresses
Authors: Lee Kristina M. 
Published: July 2020

AbstractThis paper aims to address the need in rhetorical scholarship to recognize the obstacles that atheists face in the public sphere. I propose that, within the United States, there is a systematic normalization of theism, which I refer to as theistnormativity. While theistnormativity is advanced through various systems within a society, I argue that presidents reinforce theistnormativity through their use of religious political rhetoric. I reason that the theistnormativity that is prominent in presidential inaugural addresses from 1933 to 2017 contributes an ideal space that privileges theists and marginalizes atheists.
“The Magic of Philanthropy”: The Gates Foundation’s Reframing of Education Reform Debate
Authors: Webber Jim 
Published: July 2020

AbstractThe Gates Foundation invokes a third way in education reform debate by appealing not to government regulation or market competition but to philanthropic investment as a catalyst for improving educational equity. While the foundation praises this investment as transcending the conventional polarities of debate, I argue that this praise assigns a familiar form of blame toward public education and educators, for it declares philanthropists the only reformers whose commitments to educational civil rights remain uncompromised by political-economic self-interest. In light of this analysis, I qualify the deliberative potential of praise as a rhetoric of education reform.
COVID-19 EN MÉXICO: ASOCIACIÓN ESPACIAL DE CARA A LA FASE TRES
Authors: Marcela Virginia Santana Juárez  , Castañeda Giovanna Santana , Carillo Christian Sánchez , Carrillo Ronald Sánchez , Alcántara Roque Ortega 
Published: July 2020

El propósito de este trabajo es presentar el comportamiento espacio temporal de la pandemia del COVID-19 en México, con un abordaje desde el análisis espacial, del 01 al 26 de abril de 2020, que incluye parte de la fase 2 y parte de la fase 3 de la pandemia. El método utilizado es el Índice de Moran y su gráfico de dispersión y se utilizan los gráficos de LISA (Local Indicator of Spatial Association) para analizar la dependencia espacial local, de los casos por COVID-19. Los resultados señalan que durante la fase 2 de la pandemia se caracteriza principalmente por los contagios comunitarios, en las principales zonas metropolitanas. En la tercera etapa el contagio es local, expandiéndose en forma exponencial aproximadamente 800 casos por día. En estados del centro de México, Baja California (limítrofe con los Estados Unidos), Tabasco y Quintana Roo, que registran los mayores casos. La principales conclusiones derivadas del análisis espacial es que existen grupos o clusters de municipios que son focos rojos porque registran el mayor número de casos, rodeados por municipios con valores altos; municipios con valores altos rodeados por municipios con valores bajos; municipios con valores bajos acorralados por municipios con valores altos; así como municipios con valores bajos rodeados por municipios bajos, que dependiendo de ello las políticas y medidas de mitigación deben ser diferenciadas y rigurosas, sin descuidar algún municipio.