bluuebunny/crossref_metadata_2025_split huggingface dataset:
2,3′,4,4′,5-Pentachlorobiphenyl Induced Thyrocyte Autophagy by Promoting Calcium Influx via Store-Operated Ca2+ Entry
Authors: Wang Li , Xu Wenli , Zhou Qi , Xu Bojin , Sheng Yunlu , Sun Minne , Chen Huanhuan , Wang Yucheng , Ding Guoxian , Duan Yu 
Published: July 2020

Abstract
PCB118, a 2,3′,4,4′,5-pentachlorobiphenyl, has been shown to destroy thyroidal ultrastructure and induce thyrocyte autophagy. Previously, we reported that PCB118 promoted autophagosome formation in vivo and in vitro, but more details remain to be revealed. To explore the underlying mechanism by which PCB118 regulates thyrocyte autophagy, Fischer rat thyroid cell line-5 (FRTL-5) cells were exposed to different doses of PCB118 at 0, 0.25, 2.5, and 25 nM for 0–48 h. Western blot analysis of autophagy-related proteins P62, BECLIN1, and LC3 demonstrated that PCB118 induced autophagy formation in dose- and time-dependent manner. Moreover, laser scanning confocal microscopy and flow cytometry showed PCB118 treatment led to time- and dose-dependent increase in intracellular calcium concentration ([Ca2+]i). Additionally, PCB118 promoted store-operated Ca2+ entry (SOCE) channel followed by significant increase of ORAI1 and STIM1 protein levels. On the other hand, PCB118 induced thyroidal autophagy via class III β-tubulin (TUBB3)/death-associated protein kinase 2 (DAPK2)/myosin regulatory light chain (MRLC)/autophagy-related 9A (ATG9A) pathway in FRTL-5 cells. Pretreatment with SOCE inhibitor SKF96365 reduced cytosolic Ca2+, ORAI1, STIM1, and BECLIN1 levels as well as LC3 II/LC3 I ratio, while increased P62 expression. SKF96365 also inhibited TUBB3/DAPK2/MRLC/ATG9A pathway in FRTL-5 cells treated by PCB118. Our results provide evidence that PCB118 may induce thyroidal autophagy through TUBB3-related signaling pathway, and these effects are likely to be regulated by calcium influx via SOCE channel.
Permanent Compared With Absorbable Suture for Vaginal Mesh Fixation During Total Hysterectomy and Sacrocolpopexy
Authors: Matthews Catherine A. , Geller Elizabeth J. , Henley Barbara R. , Kenton Kimberly , Myers Erinn M. , Dieter Alexis A. , Parnell Brent , Lewicky-Gaupp Christina , Mueller Margaret G. , Wu Jennifer M. 
Published: July 2020

OBJECTIVE:
To compare mesh and permanent suture exposure rates in the first year after minimally invasive total hysterectomy and sacrocolpopexy with a light-weight polypropylene mesh using permanent or delayed absorbable sutures.

METHODS:
Across five centers in the United States, women were randomized to permanent or delayed absorbable suture for vaginal attachment of a Y-mesh during hysterectomy and sacrocolpopexy for stage II prolapse and worse. The primary outcome was mesh or permanent suture exposure in the first year after surgery. The secondary outcome was to compare a composite measure for success defined as leading edge of prolapse not beyond the hymen and apex not descended more than one third vaginal length, and no subjective bulge and no prolapse retreatment. Patients completed a pelvic examination including the pelvic organ prolapse quantification system and questionnaires at baseline, 6 weeks and 1 year postsurgery. A sample size of 80 per group was planned to compare the rate of mesh or permanent suture exposure in the permanent compared with delayed absorbable groups.

RESULTS:
From April 2015 to May 2019, 204 patients (n=102 permanent; n=102 delayed absorbable) were randomized. One hundred ninety-eight women had follow-up data, with 182 (93%) completing 1-year follow-up: 95 of 99 (96%) permanent, 87 of 101 (86%) delayed absorbable. The total rate of mesh or permanent suture exposure was 12 of 198 (6.1%): 5.1% for permanent compared with 7.0% for delayed absorbable (risk ratio 0.73, 95% CI 0.24–2.22). The majority (9/12) were asymptomatic. Composite success was 93% for permanent compared with 95% for delayed absorbable suture, P=.43). Six (3.0%) women had a serious adverse event.

CONCLUSION:
Suture type used for vaginal graft attachment did not influence mesh or permanent suture exposure rates.

FUNDING SOURCE:
Boston Scientific Corporation.

CLINICAL TRIAL REGISTRATION:
ClinicalTrials.gov, NCT02277925.
Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation
Authors: Sanneh Awa , Murdock Tricia , Wethington Stephanie L. , Fader Amanda N. , Xing Deyin , Beavis Anna L. 
Published: July 2020

BACKGROUND:
Morcellation at the time of minimally invasive hysterectomy or myomectomy for presumed benign indications carries a risk of disseminating undiagnosed uterine malignancies.

CASE:
A 57-year-old woman with a remote history of laparoscopic hysterectomy with morcellation of a cellular leiomyoma presented with a newly diagnosed complex pelvic mass. Owing to adherence of the mass to the rectum and numerous peritoneal tumor implants, a surgical cytoreductive procedure was performed. The pelvic mass, implants, and original hysterectomy specimen were histologically identical and consistent with low-grade endometrial stromal sarcoma. Owing to lack of tumor–myometrial interface on the original morcellated specimen, this malignant diagnosis was not made at the time of hysterectomy.

CONCLUSION:
Morcellation of the uterus can hinder an accurate pathologic diagnosis of uterine stromal neoplasms.
Effect of thyrotropin suppressive therapy on heart rate variability and QT dispersion in patients with differentiated thyroid cancer
Authors: Liu Chunhua , Lv Haihong , Li Qian , Fu Songbo , Tan Jiaojiao , Wang Chenyi , Wang Xiaoqian , Ma Yuping 
Published: July 2020

Abstract
The effects of thyrotropin (TSH) suppressive therapy on autonomic regulation and ventricular repolarization in patients with differentiated thyroid cancer (DTC) have not been elucidated. The aim of present study was to evaluate variation in heart rate variability (HRV) and QT dispersion after TSH suppressive therapy in patients with DTC.
Cases, defined as 271 patients with DTC within 1 year of exogenous levothyroxine, and all patients underwent a full history, physical examination, including standard 12 lead electrocardiogram (ECG), and 24 h ambulatory ECG monitoring (Holter) with normal free thyroxine (FT4) and free triiodothyronine (FT3) with levothyroxine. To evaluate effects of TSH suppressive therapy on HRV and QT dispersion, patients were divided into three groups according to different levels of TSH: TSH < 0.1 mIU/L group and 0.1 ≤ TSH < 0.5 mIU/L group were as TSH suppression groups, and 0.5 ≤ TSH < 2.0 mIU/L group was as TSH replacement group.
Comparing with 0.5 ≤ TSH < 2.0 mIU/L group, significant changes in both time and frequency domain of HRV and QT dispersion were observed in TSH < 0.1 mIU/L group (P < .001: SDNN, SDANN, HF, LF/HF, QTd, and QTcd; P < .05: rMSSD) and 0.1 ≤ TSH < 0.5 mIU/L group (P < .001: SDNN, HF, LF/HF, QTd, and QTcd), and especially were more pronounced in TSH < 0.1 mIU/L group. Moreover, we found that TSH level was proportional to SDNN (β = 15.829, P < .001), but inversely proportional to LF/HF (β = −0.671, P < .001), QTd (β = −16.674, P < .001) and QTcd (β = −18.314, P < .001) in DTC patients with exogenous levothyroxine.
Compared with euthyroid state, patients with suppressed serum TSH have increased sympathetic activity in the presence of diminished vagal tone, ultimately showed sympathovagal imbalance and with an increased inhomogeneity of ventricular recovery times. These findings revealed that TSH suppression therapy had a significant impact on cardiovascular system and had certain guiding role in the treatment and management of patients with DTC.
Global Overview of Response Rates in Patient and Health Care Professional Surveys in Surgery
Authors: Meyer Vincent Maurice , Benjamens Stan , Moumni Mostafa El , Lange Johan F. M. , Pol Robert A. 
Published: July 2020

Objective:
Identify key demographic factors and modes of follow-up in surgical survey response.

Summary Background Data:
Surveys are widely used in surgery to assess patient and procedural outcomes, but response rates vary widely which compromises study quality. Currently there is no consensus as to what the average response rate is and which factors are associated with higher response rates.

Methods:
The National Library of Medicine (MEDLINE/PubMed) was systematically searched from Januray 1, 2007 until February 1, 2020 using the following strategy: (((questionnaire) OR survey) AND “response rate”) AND (surgery OR surgical). Original survey studies from surgical(-related) fields reporting on response rate were included. Through one-way analysis of variance we present mean response rate per survey mode over time, number of additional contacts, country of origin, and type of interviewee.

Results:
The average response is 70% over 811 studies in patients and 53% over 1746 doctor surveys. In-person surveys yield an average 76% response rate, followed by postal (65%) and online (46% web-based vs 51% email) surveys. Patients respond significantly more often than doctors to surveys by mail (P < 0.001), email (P = 0.003), web-based surveys (P < 0.001) and mixed mode surveys (P = 0.006). Additional contacts significantly improve response rate in email (P = 0.26) and web-based (P = 0.041) surveys in doctors. A wide variation in response rates was identified between countries.

Conclusions:
Every survey is unique, but the main commonality between studies is response rate. Response rates appear to be highly dependent on type of survey, follow-up, geography, and interviewee type.
Financial leverage, debt maturity, future financing constraints and future investment
Authors: Poursoleiman Ehsan , Mansourfar Gholamreza , Abidin Sazali 
Published: July 2020

Purpose
This paper aims to investigate the impact of debt maturity on the relationship between financial leverage and future financing constraints. Moreover, it attempts to analyze the moderating role of short-term debt and the mediating role of future financing constraints in the relationship between financial leverage and future investment.

Design/methodology/approach
To test the moderating role of debt maturity, all the observations are divided into two groups based on short-term debt to total debt ratio. Moreover, Sobel, Aroian and Goodman tests are used to analyze the mediating role of future financing constraints. The sample used in this research includes firms listed on the Tehran Stock Exchange from 2006 to 2018.

Findings
It is shown that financial leverage is inversely (positively) related to future financing constraints for firms with higher (lower) use of short-term debt and, short-term debt moderates the relation between financial leverage and future investment. The findings also indicate that future financing constraints carry the influence of financial leverage to future investment.

Originality/value
In an imperfect market where financing is not independent of investment, it is highly required to carry out some studies on the role of different financing scenarios in firms and their impacts on future financing and investment; therefore, this paper is conducted to address one of the most important issues in the capital market, which is almost the pioneer study in this field.
Ethical standards and perceptions of CRM among millennial consumers
Authors: Cosgrave David , O'Dwyer Michele 
Published: July 2020

PurposeThis study explores the millennial perceptions of cause-related marketing (CRM) in international markets through the lens of an ethical continuum. Literature gaps exist in our understanding of cause-related marketing, ethics and millennials in an international context, with few studies offering insights into successful CRM campaigns in developed vs developing countries. Previous studies have yielded differing responses based on culture, sociodemographic and consumer perceptions.Design/methodology/approachAn exploratory qualitative research method was adopted to build the theory necessary to address this research gap. Semi-structured interviews were conducted with a convenience sample of 155 undergraduate and postgraduate students representing 17 nationalities. Interviews were conducted in two regions (Ireland and United Arab Emirates) representing developed and developing markets.FindingsDiscrepancies exist between millennial consumers when it comes to ethical self-reporting, perceptions of CRM initiatives, choice criteria of CRM offers and purchase intentions. Findings also suggest that there is a relationship between the religious and ethical beliefs of millennials in certain regions. Gender showed no significant differences in perceptions of CRM.Originality/valueThis study examines millennial perceptions of CRM from multiple nationalities in developed vs developing markets. It introduces the ethical continuum in international CRM as a lens to examine perceptions of millennial consumers. The study identifies that millennials should not be treated as a homogenous group, suggesting different choice criteria of millennial consumers based on their ethical standards. It demonstrates emerging support for the role of religion in successful adoption of CRM.
A study of intention to save in Islamic banks: the perspective of Muslim students
Authors: Nugraheni Peni , Widyani Faizah Novi 
Published: July 2020

Purpose
Islamic banking provides financial products and services to fulfill the transaction needs of Muslim consumers, and Muslim students are potential consumers who can support the development of Islamic financial institutions. This study aims to examine the factors that influence the intentions of Muslim students to save in Islamic banks. Independent variables in this study are a parental recommendation, location, profit sharing, religiosity, knowledge and financial information disclosure.

Design/methodology/approach
The samples in this study are Muslim university students in Indonesia and are divided into two groups as follows: the first group has an educational background in Islamic economics gained at Islamic universities, while the second group is studying at public universities and so do not have a background of this type. The study uses questionnaires to gather data and analyzes this data using a multiple linear regression model.

Findings
For the first group, this study finds that profit-sharing, religiosity, knowledge and financial information disclosure influence the intentions of Muslim students to save in Islamic banks. The results for the second group show that parental recommendation, profit sharing and religiosity influence the intentions of Muslim students without an Islamic economic background to save in Islamic banks.

Practical implications
The implications of this study are that the university environment can influence the intention of students to save in accounts at Islamic banks. As students form an important market segment for the banking industry as a new source of accounts and for future profitability, interested parties and in particular Islamic banks may wish to consider these results as part of their strategies for attracting customers.

Originality/value
The respondents of this study consist of Muslim students in Islamic and public universities in Indonesia. The different backgrounds of the students can describe intention levels in their assessments of Islamic banks.
Knowledge management processes and organizational performance: the mediating role of organizational learning
Authors: Obeso María , Hernández-Linares Remedios , López-Fernández María Concepción , Serrano-Bedia Ana María 
Published: July 2020

Purpose
The purpose of this paper is twofold. First, it aims to analyze the individual influence of different knowledge management practises (KMP) on firm performance. Second, it aims to analyze the mediating role of organizational learning (OL) between each KMP and performance.

Design/methodology/approach
A telephone-survey was applied in 2018 to the managers of 400 Spanish firms. The data retrieved was analyzed by using multiple regression analysis.

Findings
Knowledge generation (KG) and knowledge flow (KF) promote firm performance, while there is not a direct association between knowledge storage and performance. OL mediates the relationship between KG and performance, as well as between KF and performance.

Research limitations/implications
First, this research confirms that not all the KMP have a direct effect on firm performance, thus, future research would need to differentiate between different KMP. Second, this paper is pioneering in providing empirical evidence that OL mediates the KMP – performance relationship. Third, the empirical study was performed in a context non-researched yet by the literature considering KMP individually: Spain.

Practical implications
First, besides the results managers should focus their efforts in practises related to KG and application. Second, OL mediating suggests that managers should invest in managerial commitment to promote a shared culture, shared vision, open-mind to new ideas and a lot of dialogue.

Originality/value
This is the first study that investigates how KMP contribute to firm performance by incorporating the mediating impact of OL. The results will help organizations to identify the KMP improving the performance.
Exploring influencing factors of offline knowledge service transactions on an online-to-offline knowledge-sharing economy platform
Authors: Wang Changyu , Mei Jinming , Feng Jiaojiao 
Published: July 2020

Purpose
Online-to-offline (O2O) knowledge-sharing economy platforms have emerged as a new public channel for matching up knowledge providers with knowledge seekers. It can facilitate offline provision and consumption of high-quality tacit knowledge around a topic upon online search and payment (called offline knowledge service transaction). However, limited research investigated this new knowledge-sharing phenomenon in the field of knowledge management (KM). The purpose of this paper is to enrich KM literature by developing a theoretical model to explore determinants of offline knowledge service transactions via O2O knowledge-sharing economy platforms from both quality and price perspectives.

Design/methodology/approach
The model was tested with objective data crawled from Zaihang – a leading O2O knowledge-sharing economy platform in China.

Findings
The results show that, in the context of O2O knowledge-sharing economy, transactions of an offline knowledge service are positively related to its provider’s popularity, but negatively related to the price. Moreover, knowledge seekers are more likely to accept and purchase a high-priced service of a knowledge topic with a higher overall review score and supplied by a provider with lower popularity and shorter response time. However, the length of offline knowledge service has no significant association with its transactions.

Originality/value
This study contributes to KM literature through investigating a new phenomenon of tacit knowledge sharing (including provision and consumption) in the context of O2O service and the sharing economy. The results give implications for knowledge providers and platform managers to facilitate online transactions of offline knowledge services.
Fe3O4@SiO2 magnetic nanocomposites as adsorbents for removal of diazinon from aqueous solution: isotherm and kinetic study
Authors: Shamsizadeh Zahra , Ehrampoush Mohammad Hassan , Dehghani Firouzabadi Zahra , Jasemi Zad Tahereh , Molavi Fereshteh , Ebrahimi Ali Asghar , Kamranifar Mohammad 
Published: July 2020

Purpose
The purpose of this study was to the synthesis of Fe3O4@SiO2 nanocomposites and using it as an adsorbent for removal of diazinon from aqueous solutions. Structural characteristics of the synthesized magnetic nanocomposite were described by Fourier transform infrared spectroscopy and scanning electron microscopy.

Design/methodology/approach
The effects of different parameters including pH (2-10), contact time (1-180 min), adsorbent dosage (100-2000 mg L−1) and initial diazinon concentration (0.5–20 mg L−1) on the removal processes were studied. Finally, isotherm and kinetic and of adsorption process of diazinon onto Fe3O4@SiO2 nanocomposites were investigated.

Findings
The maximum removal efficiency of diazinon (96%) was found at 180 min with 1000 mg L−1 adsorbent dosage using 0.5 mg L−1 diazinon concentration at pH = 7. The experimental results revealed that data were best fit with the pseudo-second-order kinetic model (R2 = 0.971) and the adsorption capacity was 10.90 mg g−1. The adsorption isotherm was accordant to Langmuir isotherm.

Originality/value
In the present study, the magnetic nanocomposites were synthesized and used as an absorbent for the removal of diazinon. The developed method had advantages such as the good ability of Fe3O4@SiO2 nanocomposites to remove diazinon from aqueous solution and the magnetic separation of this absorbent that make it recoverable nanocomposite. The other advantages of these nanocomposites are rapidity, simplicity and relatively low cost.
Progress in treating chronic granulomatous disease
Authors: Gennery Andrew R. 
Published: July 2020

SummaryChronic granulomatous disease is a primary immunodeficiency due to a defect in one of six subunits that make up the nicotinamide adenine dinucleotide phosphate oxidase complex. The most commonly defective protein, gp91phox, is inherited in an X‐linked fashion; other defects have autosomal recessive inheritance. Bacterial and fungal infections are common presentations, although inflammatory complications are increasingly recognized as a significant cause of morbidity and are challenging to treat. Haematopoietic stem cell transplantation offers cure from the disease with improved quality of life; overall survival in the current era is around 85%, with most achieving long‐term cure free of medication. More recently, gene therapy is emerging as an alternative approach. Results using gammaretroviral vectors were disappointing with genotoxicity and loss of efficacy, but preliminary results using lentiviral vectors are extremely encouraging.
Assisted species migration and hybridization to conserve cold‐adapted plants under climate change
Authors: Charles Kimberly M. , Stehlik Ivana 
Published: July 2020

AbstractTemperature rise due to climate change is putting many arctic and alpine plants at risk of extinction because their ability to react is outpaced by the speed of climate change. We considered assisted species migration (ASM) and hybridization as methods to conserve cold‐adapted species (or the genes thereof) and to minimize the potential perturbation of ecosystems due to climate change. Assisted species migration is the deliberate movement of individuals from their current location to where the species’ ecological requirements will be matched under climate projections. Hybridization refers to crossbreeding of closely related species, where for arctic and alpine plants, 1 parent is the threatened cold‐adapted and the other its reproductively compatible, warm‐adapted sibling. Traditionally, hybridization is viewed as negative and leading to a loss of biodiversity, even though hybridization has increased biodiversity over geological times. Furthermore, the incorporation of warm‐adapted genes into a hybrid may be the only means for the persistence of increasingly more maladapted, cold‐adapted species. If approached with thorough consideration of fitness‐related parameters of the source population and acknowledgement of the important role hybridization has played in shaping current biodiversity, ASM and hybridization could help save partial or whole genomes of key cold‐adapted species at risk due to climate change with minimal negative effects on ecosystem functioning.