bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sibling Spillovers
Authors: Black Sandra E , Breining Sanni , Figlio David N , Guryan Jonathan , Karbownik Krzysztof , Nielsen Helena Skyt , Roth Jeffrey , Simonsen Marianne 
Published: August 2020

AbstractIt is notoriously difficult to identify peer effects within the family. Using administrative data on children from both Florida and Denmark, the paper examines the effects of having a disabled younger sibling. To address the identification challenge, the paper compares the differential effects for first- and second-born children in three-plus-child families, taking advantage of the fact that birth order influences the amount of time that a child spends in early childhood with their younger siblings, disabled or not. The paper finds evidence that, relative to the first born, the second child in a family is differentially affected when the third child is disabled.
Bacterial community assembly in Atlantic cod larvae (Gadus morhua): contributions of ecological processes and metacommunity structure
Authors: Vestrum Ragnhild I , Attramadal Kari J K , Vadstein Olav , Gundersen Madeleine Stenshorne , Bakke Ingrid 
Published: August 2020

ABSTRACT
Many studies demonstrate the importance of the commensal microbiomes to animal health and development. However, the initial community assembly process is poorly understood. It is unclear to what extent the hosts select for their commensal microbiota, whether stochastic processes contribute, and how environmental conditions affect the community assembly. We investigated community assembly in Atlantic cod larvae exposed to distinct microbial metacommunities. We aimed to quantify ecological processes influencing community assembly in cod larvae and to elucidate the complex relationship between the bacteria of the environment and the fish. Selection within the fish was the major determinant for community assembly, but drift resulted in inter-individual variation. The environmental bacterial communities were highly dissimilar from those associated with the fish. Still, differences in the environmental bacterial communities strongly influenced the fish communities. The most striking difference was an excessive dominance of a single OTU (Arcobacter) for larvae reared in two of the three systems. These larvae were exposed to environments with higher fractions of opportunistic bacteria, and we hypothesise that detrimental host–microbe interactions might have made the fish susceptible to Arcobacter colonisation. Despite strong selection within the host, this points to a possibility to steer the metacommunity towards mutualistic host–microbe interactions and improved fish health and survival.
Synergistic Effects of Cognitive Training and Physical Exercise on Dual-Task Performance in Older Adults
Authors: Bherer Louis , Gagnon Christine , Langeard Antoine , Lussier Maxime , Desjardins-Crépeau Laurence , Berryman Nicolas , Bosquet Laurent , Vu Thien Tuong Minh , Fraser Sarah , Li Karen Z H , Kramer Arthur F 
Published: August 2020

AbstractBackgroundStudies report benefits of physical exercise and cognitive training to enhance cognition in older adults. However, most studies did not compare these interventions to appropriate active controls. Moreover, physical exercise and cognitive training seem to involve different mechanisms of brain plasticity, suggesting a potential synergistic effect on cognition.ObjectiveThis study investigated the synergistic effect of cognitive training and aerobic/resistance physical exercise on dual-task performance in older adults. Intervention effects were compared to active controls for both the cognitive and the exercise domain.MethodEighty-seven older adults completed one of 4 different combinations of interventions, in which computer lessons was active control for cognitive training and stretching/toning exercise control for aerobic/resistance training: (a) cognitive dual-task training and aerobic/resistance training (COG+/AER+), (b) computer lessons and aerobic/resistance training (COG−/AER+), (c) cognitive dual-task training and stretching/toning exercises (COG+/AER−), and (d) computer lessons and stretching/toning exercises (COG−/AER−). The primary outcome was performance in an untrained transfer dual task. Stepwise backward removal regression analyses were used to predict pre- versus post-test changes in groups that have completed the dual-task training, aerobic/resistance or both interventions.ResultsParticipation in AER+ did not predict improvement in any dual-task outcomes. Participation in COG+ predicted reduction in dual-task cost and participation in COG+/AER+ predicted reduction in task-set cost.DiscussionResults suggest that the combination of cognitive and physical training protocols exerted a synergistic effect on task-set cost which reflects the cost of maintaining multiple response alternatives, whereas cognitive training specifically improved dual-task cost, which reflects the ability of synchronizing concurrent tasks.
Stress, Burden, and Well-Being in Dementia and Nondementia Caregivers: Insights From the Caregiving Transitions Study
Authors: Sheehan Orla C , Haley William E , Howard Virginia J , Huang Jin , Rhodes J David , Roth David L 
Published: August 2020

Abstract

Background and Objectives
Few population-based studies have directly compared caregivers of persons with dementia to caregivers of persons with other disabilities (nondementia caregivers). We enrolled dementia and nondementia caregivers who were providing substantial and sustained care and compared these groups on measures of caregiver stressors, appraisals of burden, and well-being.

Research Design and Methods
Caregivers (N = 251) who provided continuous care for at least 1 year and at least 5 h per week were recruited from the population-based REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Caregivers reported on dementia caregiving status, stressors, burden, and well-being.

Results
Forty-seven percent (n = 117) reported caring for a person with dementia. Dementia caregivers reported more stressors, providing more care for self-care and behavioral problems than nondementia caregivers. Dementia caregivers also reported higher appraisals of stress and burden, and more depressive symptoms, but did not differ from nondementia caregivers on mental and physical health quality of life. In multivariable-adjusted models, adjustment for the total number of care recipient problems attenuated differences between dementia and nondementia caregivers on burden and depression measures.

Discussion and Implications
Dementia and nondementia caregivers showed relatively few differences in indicators of overall well-being in this population-based sample, perhaps because both groups of caregivers in this study were providing substantial care. Dementia caregivers may require special assistance with dementia-specific problems such as behavioral problems. Clinical interventions and policy changes targeting highly burdened caregivers are needed to support them in allowing their care recipients to age in place at home.
Exact closed-form solutions for Lamb’s problem—II: a moving point load
Authors: Feng Xi , Zhang Haiming 
Published: August 2020

SUMMARYIn this paper, we report on an exact closed-form solution for the displacement in an elastic homogeneous half-space elicited by a downward vertical point source moving with constant velocity over the surface of the medium. The problem considered here is an extension to Lamb’s problem. Starting with the integral solutions of Bakker et al., we followed the method developed by Feng and Zhang, which focuses on the displacement triggered by a fixed point source observed on the free surface, to obtain the final solution in terms of elementary algebraic functions as well as elliptic integrals of the first, second and third kind. Our closed-form results agree perfectly with the numerical results of Bakker et al., which confirms the correctness of our formulae. The solution obtained in this paper may lay a solid foundation for further consideration of the response of an actual physical moving load, such as a high-speed rail train.
Effects of seismogenic width and low-velocity zones on estimating slip-weakening distance from near-fault ground deformation
Authors: Chen Xiang , Yang Hongfeng 
Published: August 2020

SUMMARYFault weakening process controls earthquake rupture propagation and is of great significance to impact the final earthquake size and seismic hazard. Critical slip-weakening distance (${D_c}$) is one of the key parameters, which however is of difficult endeavours to be determined on natural faults, mainly due to its strong trade-off with the fault strength drop. An estimation method of ${D_c}$ proposed by Fukuyama et al. provides a simple and direct reference of ${D_c}$ on real faults from the near-fault ground displacement at the peak of ground velocity (${D_c}^{\prime\prime}$). However, multiple factors may affect the observed near-fault ground velocity and thus need to be considered when estimating ${D_c}.$ In this work we conduct 3-D finite element numerical simulations to examine the effects of finite seismogenic width and near-fault low velocity zones (LVZs) on the results of ${D_c}^{\prime\prime}$. In uniform models with constant prescribed ${D_c}$, the derived ${D_c}^{\prime\prime}$ values increase with seismogenic width. Furthermore, the scaling between ${D_c}^{\prime\prime}$ and final slip in models with a constant ${D_c}$ indicates that the scale-dependent feature of ${D_c}^{\prime\prime}$ might not be related to variation in friction properties. With a near-fault LVZ, ${D_c}^{\prime\prime}$ values show significant magnification. The width of the LVZ plays a more important role in enlarging ${D_c}$ estimation compared to the depth of the LVZ. Complex wavefields and multiple wiggles introduced by the LVZ could lead to delay pick and then cause large deviation. The value of ${D_c}$ on the fault may be overestimated through ${D_c}^{\prime\prime}$ from limited stations only.
Characteristics of White Matter Structural Networks in Chronic Schizophrenia Treated With Clozapine or Risperidone and Those Never Treated
Authors: Luo Chunyan , Lencer Rebekka , Hu Na , Xiao Yuan , Zhang Wenjing , Li Siyi , Lui Su , Gong Qiyong 
Published: August 2020

Abstract

Background
Despite its benefits, a major concern regarding antipsychotic treatment is its possible impact on the brain’s structure and function. This study sought to explore the characteristics of white matter structural networks in chronic never-treated schizophrenia and those treated with clozapine or risperidone, and its potential association with cognitive function.

Methods
Diffusion tensor imaging was performed on a unique sample of 34 schizophrenia patients treated with antipsychotic monotherapy for over 5 years (17 treated with clozapine and 17 treated with risperidone), 17 never-treated schizophrenia patients with illness duration over 5 years, and 27 healthy control participants. Graph theory and network-based statistic approaches were employed.

Results
We observed a disrupted organization of white matter structural networks as well as decreased nodal and connectivity characteristics across the schizophrenia groups, mainly involving thalamus, prefrontal, and occipital regions. Alterations in nodal and connectivity characteristics were relatively milder in risperidone-treated patients than clozapine-treated patients and never-treated patients. Altered global network measures were significantly associated with cognitive performance levels. Structural connectivity as reflected by network-based statistic mediated the difference in cognitive performance levels between clozapine-treated and risperidone-treated patients.

Limitations
These results are constrained by the lack of random assignment to different types of antipsychotic treatment.

Conclusion
These findings provide insight into the white matter structural network deficits in patients with chronic schizophrenia, either being treated or untreated, and suggest white matter structural networks supporting cognitive function may benefit from antipsychotic treatment, especially in those treated with risperidone.
Concurrent and Concordant Oral and Genital High-Risk Human Papillomavirus in the United States: Results from the National Health and Nutrition Examination Survey
Authors: Custer James , Patel Riddhi , Delclos George L , DeSantis Stacia M 
Published: August 2020

Abstract

Background
Oropharyngeal cancers associated with high-risk human papillomavirus (HR-HPV) infection are increasing in the United States, especially among men. We evaluated the prevalence and predictors of concurrent (genital and oral) and concordant (same-type) HR-HPV infections in the United States.

Methods
We used the National Health and Nutrition Examination Survey from 2009 to 2016. Predictors were assessed via multivariable logistic regression.

Results
Among 10 334 respondents, 172 (2.1%) had concurrent infections (109 [3.5%] men and 63 [0.76%] women]. Ninety-three (1.0%) had concordant infections (54 [1.6%] men and 39 [0.5%] women). Predictors of concurrence in men included the following: no longer married versus married (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.3–4.9), living with a partner versus married (3.0; 1.2–7.5), and having 2–5 lifetime oral sex partners (3.0; 1.2–7.5). In women they included the following: no longer married versus married (3.6; 1.3–10.3), ≥2 recent sex partners (4.6; 1.4–15.6 for 2–5 partners and 3.9; 1.1–14.3 for ≥6 partners), and marijuana use (2.2; 1.0–4.5). The predictor of concordance in men and women was no longer married versus married (3.5; 1.2–9.9 in men and 3.2; 1.1–9.4 in women).

Conclusions
Concurrent and concordant HR-HPV infections occur at a high rate, especially among men, and are associated with behavioral factors. This underscores the importance of HPV vaccination, screening, and education in men.
Microgeographic Epidemiology of Malaria Parasites in an Irrigated Area of Western Kenya by Deep Amplicon Sequencing
Authors: Hemming-Schroeder Elizabeth , Zhong Daibin , Kibret Solomon , Chie Amanda , Lee Ming-Chieh , Zhou Guofa , Atieli Harrysone , Githeko Andrew , Kazura James W , Yan Guiyun 
Published: August 2020

AbstractTo improve food security, investments in irrigated agriculture are anticipated to increase throughout Africa. However, the extent to which environmental changes from water resource development will impact malaria epidemiology remains unclear. This study was designed to compare the sensitivity of molecular markers used in deep amplicon sequencing for evaluating malaria transmission intensities and to assess malaria transmission intensity at various proximities to an irrigation scheme. Compared to ama1, csp, and msp1 amplicons, cpmp required the smallest sample size to detect differences in infection complexity between transmission risk zones. Transmission intensity was highest within 5 km of the irrigation scheme by polymerase chain reaction positivity rate, infection complexity, and linkage disequilibrium. The irrigated area provided a source of parasite infections for the surrounding 2- to 10-km area. This study highlights the suitability of the cpmp amplicon as a measure for transmission intensities and the impact of irrigation on microgeographic epidemiology of malaria parasites.
Healthcare-associated bacterial infections in the paediatric ICU
Authors: Akinkugbe Olugbenga , Cooke Fiona J , Pathan Nazima 
Published: August 2020

Abstract

Background
An estimated 3.2 million patients annually develop healthcare-associated infections (HCAIs) in Europe alone amid the major challenge of increasing antimicrobial resistance. Critically ill children warrant specific evaluation because of differences in epidemiology, causative organisms and infection sites.

Objectives
To examine the prevalence and antimicrobial susceptibility patterns of three types of HCAI in critically ill children and determine the effect on their disease course.

Materials and methods
Retrospective cohort review of critically ill children admitted to a general paediatric ICU (PICU) at a regional academic tertiary referral centre over a 3 year period.

Results
There were 1930 admissions with a median age of 38 months. Children with HCAIs had a higher incidence of comorbidities (74% versus 24%) and a longer median length of stay (8 days versus 3 days). We identified 26 positive isolates (blood, lower respiratory and urine) taken 48 h or more after admission. The combined incidence was 1.34%. Hospital-acquired pneumonia accounted for 58% of HCAIs, urinary tract infections for 31% and bloodstream infections for 11%. The majority (61.5%) of HCAIs were caused by Gram-negative organisms. Seven isolates were resistant to antimicrobials used to treat HCAI. All of these were Gram-negative organisms (Pseudomonas aeruginosa, Klebsiella oxytoca and Escherichia coli).

Conclusions
These data revealed a low incidence of HCAIs, 27% of which were resistant Gram-negative organisms. Critically ill children with HCAIs were more likely to have comorbidities and an increased length of stay. These factors may increasingly impact on PICU bed availability, an already limited resource.
Integrity of clinical information in radiology reports documenting pulmonary nodules
Authors: Lacson Ronilda , Cochon Laila , Ching Patrick R , Odigie Eseosa , Kapoor Neena , Gagne Staci , Hammer Mark M , Khorasani Ramin 
Published: August 2020

Abstract

Objective
Quantify the integrity, measured as completeness and concordance with a thoracic radiologist, of documenting pulmonary nodule characteristics in CT reports and assess impact on making follow-up recommendations.

Materials and Methods
This Institutional Review Board-approved, retrospective cohort study was performed at an academic medical center. Natural language processing was performed on radiology reports of CT scans of chest, abdomen, or spine completed in 2016 to assess presence of pulmonary nodules, excluding patients with lung cancer, of which 300 reports were randomly sampled to form the study cohort. Documentation of nodule characteristics were manually extracted from reports by 2 authors with 20% overlap. CT images corresponding to 60 randomly selected reports were further reviewed by a thoracic radiologist to record nodule characteristics. Documentation completeness for all characteristics were reported in percentage and compared using χ2 analysis. Concordance with a thoracic radiologist was reported as percentage agreement; impact on making follow-up recommendations was assessed using kappa.

Results
Documentation completeness for pulmonary nodule characteristics differed across variables (range = 2%–90%, P &lt; .001). Concordance with a thoracic radiologist was 75% for documenting nodule laterality and 29% for size. Follow-up recommendations were in agreement in 67% and 49% of reports when there was lack of completeness and concordance in documenting nodule size, respectively.

Discussion
Essential pulmonary nodule characteristics were under-reported, potentially impacting recommendations for pulmonary nodule follow-up.

Conclusion
Lack of documentation of pulmonary nodule characteristics in radiology reports is common, with potential for compromising patient care and clinical decision support tools.
A review on the woody breast condition, detection methods, and product utilization in the contemporary poultry industry
Authors: Caldas-Cueva Juan P , Owens Casey M 
Published: August 2020

Abstract
In recent years, the global poultry industry has been facing increasing and challenging myopathies such as the woody breast (WB) condition that has caused significant economic losses. Even though the etiological causes of WB myopathy are still unknown or partially understood, the intensive genetic selection for rapid-growth rates and high yields in broilers may be the main factor associated with the development of this abnormality. The severity of this anomaly and its incidence rates are associated with fast-growing and heavier broilers, especially with those from high breast yielding strains. Such WB myopathy is primarily characterized by a notorious hardness in broiler breast muscles, which exhibit morphometric and histopathological alterations coupled with physicochemical abnormalities that result in undesired sensory, nutritional, and technological properties. In this negative context, although scientists are trying to solve or reduce the prevalence of this meat quality problem, the poultry industry needs noncontact and rapid in-line methods for WB detection at the fillet and/or carcass level that could help to establish automated objective grading or sorting systems according to its severity. Another need is the development and selection of profitable alternatives for the utilization of WB meat once poultry carcasses or deboned fillets affected by this abnormality are objectively detected and sorted. Indeed, there is a need for studies to expand the industrial applications of WB meat in further processed products, optimizing the incorporation of this affected chicken meat based on sensorial, technological, and nutritional profile evaluations. Even though a better understanding of the contribution of genetic and nongenetic factors to the development of growth-related myopathies can be the main strategy to mitigate their negative effects, the poultry industry could benefit from meeting the aforementioned needs.
The combination of nutraceuticals and functional feeds as additives modulates gut microbiota and blood markers associated with immune response and health in weanling piglets
Authors: Lo Verso Luca , Talbot Guylaine , Morissette Bruno , Guay Frédéric , Matte J Jacques , Farmer Chantal , Gong Joshua , Wang Qi , Bissonnette Nathalie , Beaulieu Carole , Lessard Martin 
Published: August 2020

AbstractThis study aimed to evaluate the effects of a combination of feed additives with complementary functional properties on the intestinal microbiota, homocysteine, and vitamins E and B status as well as systemic immune response of weanling piglets. At weaning, 32 litters were assigned to one of the following dietary treatments (DT): 1) conventional diet (CTRL); 2) CTRL diet supplemented with antibiotics (ATB); 3) a cocktail of feed additives containing cranberry extract, encapsulated carvacrol, yeast-derived products, and extra vitamins A, D, E, and B complex (CKTL); or 4) CKTL diet with bovine colostrum in replacement of plasma proteins (CKTL + COL). Within each litter, the piglets with lowest and highest birth weights (LBW and HBW, respectively) and two piglets of medium birth weight (MBW) were identified. The MBW piglets were euthanized at 42 d of age in order to characterize the ileal and colonic microbiota. Blood samples were also collected at weaning and at 42 d of age from LBW and HBW piglets to measure insulin-like growth factor-1 (IGF-1), cysteine, homocysteine, and vitamins E, B6, and B12, and to characterize the leukocyte populations. At 42 d of age, cytokine production by stimulated peripheral blood mononuclear cells was also measured. In a second experiment, piglets were reared under commercial conditions to evaluate the effects of the DT on the growth performance. At the indicator species analysis, the highest indicator value (IV) for Succinivibrio dextrinosolvens was found in the CKTL group, whereas the highest IV for Lactobacillus reuteri and Faecalibacterium prausnitzii was evidenced in the CKTL + COL group (P &lt; 0.05). Compared with the other DT, CTRL piglets had higher concentrations of homocysteine, whereas the CKTL and CKTL + COL supplementations increased the concentrations of vitamins E and B12 (P &lt; 0.05). DT had no effect on IGF-1 concentration and on blood leukocytes populations; however, compared with HBW piglets, LBW animals had lower values of IGF-1, whereas the percentages of γδ T lymphocytes and T helper were decreased and increased, respectively (P &lt; 0.05). CKTL + COL also improved the growth performance of piglets reared under commercial conditions (P &lt; 0.05). This study highlights the impact of birth weight on piglet systemic immune defenses and the potential of weaning diet supplemented with feed additives and bovine colostrum to modulate the homocysteine metabolism and the intestinal microbiota.