bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of concomitant 177Lu-DOTATATE and low-dose capecitabine in advanced medullary thyroid carcinoma: a single-centre experience
Authors: Satapathy Swayamjeet , Mittal Bhagwant Rai , Sood Ashwani , Verma Roshan , Panda Naresh 
Published: May 2020

Aims
Peptide receptor radionuclide therapy (PRRT) has been shown to be useful in inoperable/metastatic medullary thyroid carcinoma (MTC). However, the role of concomitant PRRT and low-dose capecitabine therapy has not yet been studied in these patients. This study was conducted to evaluate the efficacy and safety of this combination approach in advanced MTC.

Materials and methods
This was a retrospective, single-centre study. Data of consecutive patients of advanced inoperable/metastatic MTC treated with concomitant 177Lu-DOTATATE+capecitabine, from January 2014 to August 2018, were collected and analysed for radiological, molecular and biochemical responses and treatment-related toxicity.

Results
Eight patients with advanced MTC received a median cumulative dose of 20.9 GBq (interquartile range 8.9–27.7 GBq) 177Lu-DOTATATE over 1–4 cycles and 1250 mg/m2 capecitabine from days 0 to 14 of each PRRT cycle. Radiological response according to Response Evaluation Criteria in Solid Tumours 1.1 criteria could be assessed in seven patients. Six out of seven patients (86%) had stable disease, while disease progression was observed in 1/7 (14%) patients. However, molecular response, as per the European Organization for Research and Treatment of Cancer criteria, was observed in all the seven patients. Biochemical response with reduction in serum calcitonin levels was observed in 3/5 (60%) patients. With the exception of grade 2 anaemia in one patient, no other significant toxicity was observed in this cohort.

Conclusion
Our results indicate the efficacy and safety of concomitant 177Lu-DOTATATE and capecitabine in advanced MTC. Larger randomized controlled trials are, however, required to establish the role of capecitabine as a radiosensitizer along with PRRT in these patients.
Long-term complications of acute kidney injury in children
Authors: Lebel Asaf , Teoh Chia W. , Zappitelli Michael 
Published: May 2020

Purpose of review
The current review will describe the current evidence and mechanisms of acute kidney injury (AKI) as a risk factor for long-term kidney complications, summarize the rationale for AKI follow-up and present an approach to monitoring children with AKI. Despite emerging evidence linking AKI with risk for long-term kidney and cardiovascular outcomes, many children who develop AKI are not followed for kidney disease development after hospital discharge. Better understanding of long-term complications after AKI and practical algorithms for follow-up will hopefully increase the rate and quality of post-AKI monitoring.

Recent findings
Recent evidence shows that pediatric AKI is associated with long-term renal outcomes such as chronic kidney disease (CKD) and hypertension, both known to increase cardiovascular risk. The mechanism of AKI progression to CKD involves maladaptive regeneration of tubular epithelial and endothelial cells, inflammation, fibrosis and glomerulosclerosis. Many AKI survivors are not followed, and no guidelines for pediatric AKI follow-up have been published.

Summary
Children who had AKI are at increased risk of long-term renal complications but many of them are not monitored for these complications. Recognizing long-term outcomes post-AKI and integration of follow-up programs may have a long-lasting positive impact on patient health.
The aging transplant population and immunobiology: any therapeutic implication?
Authors: Schaenman Joanna , Goldwater Deena 
Published: May 2020

Purpose of review
The aim of this review is to describe the latest investigations into the immunobiology of aging and the potential impact on outcomes after mechanical circulatory support implantation and heart transplantation. This information is relevant given the growing numbers of older patients with heart failure undergoing evaluation for mechanical circulatory support device (MCSD) or heart transplantation.

Recent findings
A host of aging-associated aspects of immune dysfunction have been described in the general population including T-cell senescence, exhaustion, and terminal dedifferentiation, as well as impaired function of innate immune cells. Another important consequence of T-cell senescence is inflammation, which is known to have a strong relationship with both heart failure and frailty in older patients. Recent data on the association between T-cell and monocyte phenotypes as well as evaluation of gene expression and adverse outcomes after MCSD suggests the potential value of immunologic assessment of MCSD and heart transplant candidates and recipients. Measurement of physical frailty represents another avenue for patient evaluation that may complement immunologic assessment. Determination of immune dysfunction and frailty prior to transplantation may have implications for choice of induction and dosing of maintenance immunosuppression.

Summary
As the age of transplant and MCSD candidates and recipients continues to increase, it is important for providers to recognize the potential impact of aging-associated immune dysfunction and how it may influence candidate selection, postintervention monitoring, and adjustment of immunosuppression.
Implementing Insurance Billing in Local Health Department Sexually Transmitted Disease Clinics in Virginia, 2017
Authors: McGee Felencia , Carter Ashley , Lafon Emily , Chesson Harrell 
Published: May 2020

Abstract
In 2017, the Virginia Department of Health implemented billing of insurance in local health department sexually transmitted disease clinics. We examined data collected by Virginia Department of Health related to clinic encounters, billing, and revenue from sexually transmitted disease clinics statewide. Implementing insurance billing created a new revenue stream for local health departments.
Where Are We Now? A Content Analysis of Canadian Master of Public Health Course Descriptions and the Public Health Agency of Canada's Core Competencies
Authors: Apatu Emma , Sinnott Will , Piggott Thomas , Butler-Jones David , Anderson Laura N. , Alvarez Elizabeth , Dobbins Maureen , Harrison Leila , Neil-Sztramko Sarah E. 
Published: May 2020

Objective:
To examine the degree to which Master of Public Health (MPH) programs' course descriptions align with the Public Health Agency of Canada's (PHAC's) core competency categories in order to identify strengths and training gaps in such programs across Canada.

Methods:
A content analysis of MPH programs in Canada was conducted from July 2019 to November 2019. A sampling frame of programs was obtained from a list from the PHAC Web site. Program information, including mandatory and elective course descriptions, was extracted from each program's Web site and analyzed in NVivo 12. Course descriptions were independently categorized by 2 researchers into 1 or more of the 7 categories of the core competencies outlined by the PHAC.

Results:
We identified 18 universities with MPH programs with 267 courses across Canada. Thematic analysis revealed that 100% of programs had coursework that addressed the “Public Health Sciences” and “Assessment and Analysis” categories; 93% addressed “Policy and Program Planning, Implementation, and Evaluation”; 67% addressed each of “Communication,” “Leadership,” and “Partnerships, Collaboration, and Advocacy”; and only 56% had course descriptions addressing “Diversity and Inclusiveness.”

Conclusions:
We find that Canadian MPH programs may lack course offerings addressing core competency categories relating to diversity and inclusiveness, communication, and leadership. Our findings were limited in scope as we relied on program Web sites; thus, further research should explore course content in more depth than this course description analysis allowed and identify ways to close the MPH curricular gaps we identified.
Comparison of 68Ga-FAPI and 18F-FDG PET/CT in a Patient With Cholangiocellular Carcinoma
Authors: Pang Yizhen , Hao Bing , Shang Qihang , Sun Long , Chen Haojun 
Published: May 2020

Abstract
The present study compared 68Ga-FAPI and 18F-FDG PET/CT in a patient with cholangiocellular carcinoma. In this case, 68Ga-FAPI PET shows much higher tumor-to-background contrast of primary tumor and reveals more metastatic lesions, especially the micrometastases of bones, than 18F-FDG PET.
Endoscopic Endonasal Approach for Resection of Tuberculum Sellae Meningioma: A Promising Surgical Approach
Authors: Zhang Cheng , Ding Jianling , Liu Ye , Tuoheti Maimaitiyiming , Yang Xiaopeng , Wang Jichao , Wu Yonggang 
Published: May 2020

Background:
Over the past decade, endoscopic approaches have been increasingly successful in removing various types of extra-dural lesions from the skull base. Resection of tuberculum sellae meningiomas (TSMs) is challenging. The endoscopic endonasal approach (EEA) for the removal of TSMs is currently an acceptable surgical approach in neurosurgery and, despite the surgical results, the indications and limitations of this approach remain controversial.

Objective:
This paper reviews the authors’ experience and outcomes with the EEA for TSM, as well as postoperative complications.

Methods:
Retrospective analyses were performed on patients who underwent endoscopic surgical resection of TSMs involving the suprasellar region between January 2018 and March 2019.

Results:
Three patients underwent resection of their TSM by the EEA. Tumors in the suprasellar region were completely resected. Patients recovered normally with uneventful postoperative outcomes and were followed-up for at least six months after surgery with no neurological deficits noted.

Conclusions:
The EEA for resection of TSMs is feasible, safe, and effective, with fewer complications and lower mortality than other surgical methods. This a promising surgical approach.
Giant Cephalocele Case Mimicking Cystic Neoplasia in Skull Base
Authors: Gozgec Elif , Ogul Hayri 
Published: May 2020

Abstract
Petrous apex cephalocel, also called arachnoid cyst or meningocele, is a rare cephalocele caused by protrusion of the posterolateral wall of the Meckel cave to the petrous apex. Increased intracranial pressure is thought to play a role in etiopathogenesis and is generally asymptomatic. Radiologically, they are expansile lesions with the same density or intensity as cerebrospinal fluid and may mimic cystic masses. The diagnosis is made by showing the continuity with Meckel cave on magnetic resonance imaging. No intervention is required in asymptomatic patients; surgical treatment is applied in symptomatics.
A Custom-Made Nostril Retainer for Adult Population
Authors: Ozkan Burak , Albayati Abbas , Akinci Kadri , Uysal Cagri A. , Ertas Nilgun M. 
Published: May 2020

Abstract
Nostril retainers are used in cleft lip nose surgery in the post-operative period to maintain alar diameter and resistance against contraction. Various custom made splints were described in the literature to mimic this function when nostril retainers cannot be used for economic or logistic reasons. The authors designed a nostril retainer made by silicone urinary catheter for adult age patients which can be prepared easily. The splint can be used in both unilateral cleft lip nose surgery and operations in the alar wing of the nose.
Protruding Meningioma of the Forehead With Extensive Hyperostosis Mimicking Skull Osteoma
Authors: Seo Du-Heon , Shin Jin Yong , Roh Si-Gyun , Chang Suk Choo , Lee Nae-Ho 
Published: May 2020

Abstract
Meningioma is the most common intracranial benign tumor in adults. Hyperostosis accompanies about 4.5% of meningiomas. The authors report a rare case of hyperostotic meningioma that may have been misdiagnosed as giant osteoma.
A 42-year male visited our clinic due to an egg-sized, hard mass on his left forehead. The mass suspected to be giant osteoma was about 4.2 × 4.0 cm sized, hard, non-movable, and non-tender. But based on radiologic findings, the mass was diagnosed as meningioma with extensive hyperostosis.
Without neurologic symptoms, the diagnosis of meningioma associated with hyperostosis can be challenging and be misdiagnosed as fibrous dysplasia and osteoma by simple examination without enhanced CT and MRI.
Therefore, although osseous lesions are strongly suspected to be osteomas, surgeons should consider other diagnoses, and if necessary, use contrast enhanced CT or MRI to differentiate these bony lesions.
Minimally Invasive Method for Correcting Reducible Cryptotia
Authors: Shin Hyojeong , Shin Jeonghwan , Song Jong Keun , Ko Jun Gul , Lee Jun Yong 
Published: May 2020

Abstract
Various surgical methods have been used to treat cryptotia; however, there is a drawback of these methods in that they leave a permanent scar. The authors describe a 7-year-old child who missed the optimal corrective time for cryptotia. Minimally invasive surgery was planned as a 3rd alternative to external splinting or invasive surgery by taking advantage of 2 methods. Silly putty was prefabricated as an auricular sulcus retainer, and fixation sutures between the deep dermis and temporal fascia were placed through small incisions along the future auricular sulcus. Then the prefabricated auricular sulcus retainer was maintained for 2 months. After 6 months, the corrected ear shape remained stable with the inconspicuous scar. With minimally invasive correction, a successful treatment effect can be expected while minimizing scarring in patients who are not expected to have a therapeutic effect with a simple reduction.
Facial Nerve Palsy Associated With Orthognathic Surgery
Authors: Bisatto Natália Valduga , Andriola Fernando de Oliveira , Barreiro Bernardo Ottoni Braga , Maahs Thomas Peter , Pagnoncelli Rogério Miranda , Fritscher Guilherme Genehr 
Published: May 2020

Abstract
The authors report a 25-year-old female who presented facial palsy after undergoing bimaxillary orthognathic surgery for retrognathism correction. Orthognathic surgery is a procedure used to treat dentofacial deformities which aims to achieve an adequate relationship between dental archs, improving function (such as chewing, breathing, and speaking) and facial aesthetics. Even though there are some complications that can occur during the intraoperative and postoperative periods like bleeding, tooth, soft-tissue damage, nerve damage, bad split, infection, and nonunion, facial nerve injuries are considered rare complications after this kind of surgical procedure. Despite being uncommon, rarely described, transient, and spontaneously resolved in almost all patients, facial nerve palsy is one of the most serious complications because it directly affects patient's quality of life and social interaction.
Giant Lipoma of the Anterior Neck Causing Dyspnea
Authors: Cukic Ognjen 
Published: May 2020

Abstract
Lipomas are the most common benign mesenchymal tumors, composed of mature adipocytes, and may occur anywhere in the body where fatty tissue is present. Neck lipomas are rare and usually appear as solitary, small (<5 cm), and asymptomatic lesions located in the subcutis of posterior neck. Giant anterior neck lipomas are exceptionally rare and, other than cosmetic concerns, seldom present with respiratory symptoms. A 37-year-old female patient was referred for a long-standing anterior and right-sided neck swelling, which had markedly increased in size causing cosmetic disfigurement, neck discomfort, and transient episodes of dyspnea when lying on the side opposite the neck mass. Under general anesthesia, the lesion was completely dissected and removed through the elliptical cervical incision over the right supraclavicular fossa, while carefully preserving the surrounding neck structures. The postoperative recovery was uneventful and the patient was satisfied with the cosmetic outcome and relief of her respiratory symptoms.
Evaluation of Complications After Open Reduction and Internal Fixation of Mandibular Condylar Base and Neck Fractures Using Trapezoidal Plates
Authors: Smolka Wenko , Liokatis Paris , Cornelius Carl-Peter 
Published: May 2020

Abstract
The purpose of the study was to evaluate the different fracture pattern of patients being treated with trapezoidal plate fixation of condylar base and neck fractures using the AOCMF Classification System to determine specific fracture pattern that are associated with failure of trapezoidal plate fixation. Ten patients with mandibular condylar base and neck fractures underwent internal fixation using trapezoidal plates. Fractures of the condylar process were classified according to the AOCMF Classification System using computed tomography data. The fracture pattern was compared to complications according to hardware failure such as plate or screw loosening and plate fracture. Plate and screw loosening of trapezoidal plates for fixation of condylar base and neck fractures was associated with fracture location in the neck region and major fragment displacement with contact loss between the proximal and distal fragment of the fracture. Further investigations such as finite-element analysis of different plating systems for fixation of condylar neck fractures are necessary to establish the optimal fixation technique for condylar neck fractures.
Extracorporeal Shock-Wave Therapy or Low-Level Laser Therapy: Which is More Effective in Bone Healing in Bisphosphonate Treatment?
Authors: Göl Esma Bilge , Özkan Nilüfer , Bereket Cihan , Önger Mehmet Emin 
Published: May 2020

Objectives:Bisphosphonate-related osteonecrosis of the jaw is potential side effect of long-term bisphosphonate therapy. Different treatment modalities have been used in this and investigate the effects of low-level laser therapy (LLLT) and extracorporeal shockwave therapy (ESWT) on socket healing after tooth extraction in rats given long-term bisphosphonates.Methods:Forty male Wistar-Albino rats were used in this experimental study. About 0.1 mg/kg zoledronic acid was administered intraperitoneally to all animals 3 times per week for 8 weeks. Four groups were made which were control, LLLT, ESWT, and ESWT+LLLT. Upper right first molar teeth extraction was performed in all groups; no treatment was given to the control group after molar tooth extraction. About 810 nm wavelength GaAlAs laser was used in LLLT group. In ESWT group, 1000 pulses, 0.21 mJ/mm2ESWT was applied, and the 2 treatment methods were applied to the last ESWT+LLLT group at the same time. All the 4 groups were divided into 2 subgroups according to sacrification time 4 and 8 weeks. Steorologic, histologic, and immunohistochemical examinations were performed.Results:The highest new bone volume was observed in the early LLLT+ESWT. New vessel volume and CD31 expression were found to be high in the LLLT group. matrixmetalloproteinaze (MMP)-2 expression was found increased by the application of LLLT and ESWT.Conclusion:The LLLT and ESWT have similar effect on socket healing in the early period and that co-use is more effective upon healing. The LLLT has been shown to increase CD31 expression and increase vascularization and soft-tissue healing.
Reflections on Career Pathways of Simulation-Focused Experts in the Field
Authors: Sanko Jill Steiner , Calhoun Aaron W. , Issenberg S. Barry , Kelly Michelle , Battista Alexis 
Published: May 2020

Summary Statement
This article presents reflections of career pathways of simulation researchers as well as a discussion of the themes found in the stories presented. It is the intent of the authors to present and foster a discussion around the ways in which we as a simulation community wish to promote recognition of scholarship among simulation researchers and help support newcomers find success as simulation researchers in academia. We also present recommendations for those considering entering the field based on tactics that were successful and not successful among the scholars who shared their stories.
Clinical Implementation of Prolonged Liver Preservation and Monitoring Through Normothermic Machine Perfusion in Liver Transplantation
Authors: Cardini Benno , Oberhuber Rupert , Fodor Margot , Hautz Theresa , Margreiter Christian , Resch Thomas , Scheidl Stefan , Maglione Manuel , Bösmüller Claudia , Mair Harald , Frank Marion , Augustin Florian , Griesmacher Andrea , Schennach Harald , Martini Judith , Breitkopf Robert , Eschertzhuber Stephan , Pajk Werner , Obwegeser Alois , Tilg Herbert , Watson Christopher , Öfner Dietmar , Weissenbacher Annemarie , Schneeberger Stefan 
Published: May 2020

Background.
Normothermic machine perfusion (NMP) bears the potential for significant prolongation of liver preservation before transplantation. Although safety and feasibility have been recently published, no data are available describing the significant challenges of establishing NMP programs outside clinical studies. We herein present our experience and propose a multidisciplinary approach for liver NMP in the clinical routine.

Methods.
In February 2018, liver NMP was introduced for routine use in marginal organs, logistic challenges, and complex recipients at our institution. In a multidisciplinary effort among transplant coordinators, perfusionists, transplant surgeons, anesthesia, nurses, blood bank as well as laboratory staff, a clinical routine was established and 34 NMP cases were performed without critical incidents or organ loss.

Results.
Nine livers were discarded due to poor organ quality and function observed during NMP. Twenty-five livers were successfully transplanted after preservation of up to 38 h. The extended criteria donors rate was 100% and 92% in discarded and transplanted livers, respectively. Nighttime procedures and parallel transplantations were eventually omitted. Graft and patient survival was 88% at 20 mo. No cholangiopathy was observed despite the use of extended criteria donor organs in 92% of cases.

Conclusions.
NMP in a multidisciplinary approach enables a safe prolongation of liver preservation and overnight organ care. A first field test of NMP indicates safety and benefit of this approach.
A Multi-perspective Analysis of Retractions in Life Sciences
Authors: Bhatt Bhumika 
Published: May 2020

AbstractThe aim of this study is to explore trends in retracted publications in life sciences and biomedical sciences over axes like time, countries, journals and impact factors, and topics. Nearly seven thousand publications, which comprise the entirety of retractions visible through PubMed as of August 2019, were used. This work involved sophisticated data collection and analysis techniques to use data from PubMed, Wikipedia, and WikiData, and study it with respect to the above mentioned axes. Importantly, I employ state-of-the-art analysis and visualization techniques from natural language processing (NLP) to understand the topics in retracted literature. To highlight a few results, the analyses demonstrate an increasing rate of retraction over time and noticeable differences in the publication quality (as measured by journal impact factor) among top countries. Moreover, while molecular biology and cancer dominate retractions, we also see a number of retractions not related to biology. The methods and results of this study can be applied to continuously understand the nature and evolution of retractions in life sciences, thus contributing to the health of this research ecosystem.