bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequent Avoidable Admissions Amongst Aboriginal and Non-Aboriginal People with Chronic Disease in New South Wales, Australia: A Retrospective Cohort Study
Authors: Jayakody Amanda Anne , Oldmeadow Christopher , Carey Mariko , Bryant Jamie , Evans Tiffany , Ella Stephen , Attia John , Towle Simon , Sanson-Fisher Robert 
Published: July 2020

Abstract
Background: Aboriginal and Torres Strait Islander people have high rates of avoidable hospital admissions for chronic diseases, however little is known about the frequency of avoidable admissions for this population. This study aimed to examine trends in avoidable admissions among Aboriginal and non-Aboriginal people with ambulatory care sensitive chronic conditions in New South Wales (NSW), Australia. Methods: A retrospective cohort analysis using de-identified linked administrative data of Aboriginal and non-Aboriginal patients between 2005/06 to 2013/14. Eligible patients were admitted to a NSW public hospital and who had one or more of the following ambulatory care sensitive chronic conditions as a principal diagnosis: diabetic complications, asthma, angina, hypertension, congestive heart failure and/or chronic obstructive pulmonary disease. The primary outcomes were the number of avoidable admissions for an individual in each financial year, and whether an individual had three or more admissions compared with one to two avoidable admissions in each financial year. Poisson and logistic regression models and a test for differences in yearly trends were used to assess the frequency of avoidable admissions over time, adjusting for sociodemographic variables and restricted to those aged ≤75 years.Results: There were a total of 27,467 avoidable admissions corresponding to 19,025 patients over the nine-year period (71.2% Aboriginal; 28.8% non-Aboriginal). Aboriginal patients were 15% more likely than non-Aboriginal patients to have a higher number of avoidable admissions per financial year (IRR=1.15; CI: 1.11, 1.20). Aboriginal patients were almost twice as likely as non-Aboriginal patients to experience three or more avoidable admissions per financial year (OR=1.90; CI=1.60, 2.26). There were no significant differences between Aboriginal and non-Aboriginal people in yearly trends for either the number of avoidable admissions, or whether or not an individual experienced three or more avoidable admissions per financial year (p=0.8599; 0.8608 respectively). Conclusion: Aboriginal people were significantly more likely to experience frequent avoidable admissions over a nine-year period compared to non-Aboriginal people. These high rates reflect the need for further research into which interventions are able to successfully reduce avoidable admissions among Aboriginal people with chronic diseases, and the importance of culturally appropriate early prevention and community health care.
Potential Hospital Care Accessibility Scores: Association with Healthcare Utilization and Non-Hospital Care Service Accessibility
Authors: GAO Fei , Jaffrelot Matthieu , Deguen Séverine 
Published: July 2020

Abstract
Background: Optimal healthcare access improves people's health status and decreases health inequalities. Many studies demonstrated spatial access importance in health outcomes. Recent studies assessed spatial healthcare access using the enhanced two-step floating catchment area (E2SFCA) method. The aim of this study was to build a hospital facility access indicator at a fine geographic scale and to determine whether there is a complementarity between non-hospital and hospital care accessibility by investigating the length of hospital stays (LOS). Methods: This study focused on the ≥75-year-old population of the Nord administrative region of France. Hospital spatial accessibility was computed with the E2SFCA method, and then the LOS score was calculated from the French national hospital activity and patient discharge database. Linear regression models were used to analyze the relationship between LOS and spatial accessibility to hospital-based care and to the three types of non-hospital care services (general practitioners, physiotherapists, and home-visiting nurses). Results: Overall, there were 19.0 beds in Medical, Surgical and Obstetrics (MCO) facilities and 5.58 beds in Postoperative and Rehabilitation Care facilities (SSR) per 10,000 inhabitants, but with important geographic variations. Accessibility to hospital services was higher for people in large urban areas, despite the dense population and the higher demand. In 2014, the mean LOS scores were 0.26 for MCO and 0.85 for SSR, with a non-homogeneous geographical repartition. Linear regression analysis revealed a strong negative and significant association between hospital and non-hospital care accessibility.Conclusions: This is the first study to measure spatial accessibility to hospital-based cares in France using the E2SFCA method, and the first to investigate the relationship between spatial accessibility to hospital-based care facilities and three types of non-hospital care services and healthcare utilization (LOS). Our findings should help to take decisions about deploying additional beds and to identify the best locations for non-hospital care services. Moreover, they should also help to improve access, and to ensure the best coordination and sustainability of inpatient and outpatient services, in order to better cover the population’s healthcare needs. Other international studies using multiple consensual indicators of healthcare outcomes and accessibility and sophisticated modeling methods should be developed.
Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease
Authors: Yari Fatemeh Ali , Shabani Parisa , Karami Sara , Sarmadi Negar , Poustchi Hossein , Bandegi Ahmad Reza 
Published: July 2020

Abstract
Background: Family with sequence similarity 19 (chemokine (C-C motif)-like) member A5 (FAM19A5) is a newly identified adipokine. There is a limited number of studies linking FAM19A5 to metabolic disorders. In the current study, we aimed to explore if FAM19A5 is associated with nonalcoholic fatty liver disease (NAFLD). We also sought to determine the possibility of FAM19A5 association with subclinical atherosclerosis in NAFLD patients. Methods: A total of 69 subjects including 37 NAFLD and 32 control subjects were included in this cross-sectional study. Plasma concentration of FAM19A5 was measured with the ELISA method. Carotid artery intima-media thickness (cIMT) was assessed by the ultrasonography.Results: Plasma concentration of FAM19A5 in patients with NAFLD was significantly lower in NAFLD patients than controls. Moreover, we observed significant negative correlations between plasma level of FAM19A5 and body mass index (BMI), visceral fat, alanine amino transferase (ALT), aspartate amino transferase (AST), liver stiffness (LS), and cIMT. Following stepwise multiple linear regression analysis, ALT and cIMT were the only determinants of FAM19A5 level. Conclusions: This is the first report to describe association of circulating FAM19A5 levels with NAFLD. Our findings provide further evidence showing relation of FAM19A5 with the risk of atherosclerosis. However, more studies are necessary to unravel the contribution of lower FAM19A5 levels to the NAFLD pathogenesis and the higher risk of atherosclerosis in these patients.
Effect of Combined Training on Body Image in Women with Breast Cancer: Controlled Clinical Trial
Authors: Reis Andréa Dias , Pereira Paula Tâmara Vieira Teixeira , Filha Jurema Gonçalves Lopes Castro , Rodrigues Evelyn Feitosa , Laranjeira Isadora Pinheiro , Ramallo Bianca Trovello , Castro Marcela Rodrigues de , Rossi Fabrício Eduardo , Júnior Ismael Forte Freitas , Garcia João Batista Santos 
Published: July 2020

Abstract
Background: Improvement in body image in women with breast cancer may be linked to altered functional capacity, regardless of body composition. The aim of this study was to evaluate the effect of combined training (CT) on body image in patients with breast cancer. Methods: A Clinical Trial study, this was a controlled study including 26 patients with breast cancer (30 to 59 years). The patients were allotted to either the Training Group (TG)(n = 13), which underwent 12 weeks of CT (aerobic, resistance, and flexibility), or the Control Group (CG) (n = 13), which received only the standard hospital treatment. Participants were evaluated at baseline and after 12 weeks. Results: The patients in the TG showed a significant reduction in the limitation dimension (p = 0.036), and an increase in VO2max (p = < 0.001) and strength in the right (p = 0.005) and left arms (p = 0.033). However, the participants also presented an increase in waist circumference (p = 0.034). Conclusion: Women with breast cancer presented improved body image and functional ability through CT. Trial registration: NCT03061773. Date: February 23, 2017, retrospective.
Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes with Exudative Circumscribed Choroidal Haemangioma : An Optical Coherence Tomography Angiography Study
Authors: Lai Kunbei , Huang Chuangxin , Zhang Yali , Xu Faobao , Zhong Xiaojing , Cheng Lin , Gong Yajun , Li Longhui , Jin Chenjin 
Published: July 2020

Abstract
Background: To quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma (CCH) compared with age- and gender-controlled healthy eyes.Methods: This was a cross-sectional, case-control study. 82 eyes of eighty-two subjects including 41 eyes of forty-one subjects in the exudative CCH group and 41 eyes of forty-one subjects in the age- and gender-controlled healthy eye group were enrolled in this study. Optical coherence tomography angiography (OCTA) was performed in each subject, and the capillary density (CD) of superficial plexus, deep capillary plexus, and the choriocapillaris as well as the area of foveal avascular zone (FAZ) were noted and analyzed between two groups.Results: The CD of the superficial plexus (44.51 ± 3.58 % vs 47.93 ± 2.94%) and deep plexus (47.75 ± 5.60% vs 52.66 ± 5.04%) of retina as well as the vessel density of choriocapillaris (54.42 ± 6.36% vs 61.83 ± 3.65%) significantly decreased in eyes with exudative CCH compared with age- and gender-controlled healthy eyes (all P < 0.001). Although we found that the FAZ areas in the exudative CCH group was larger than that of the healthy eye control group (0.30 ± 0.11mm2 vs 0.27 ± 0.87mm2), however, no statistical significance was found between two groups (P = 0.164).Conclusions: OCTA is a rapid, non-invasive, high-resolution procedure with which could monitor the parafoveal microvasculature changes in eyes with exudative CCH. We found that not only the CD of the superficial plexus and deep plexus but also the CD of choriocapillaris significantly decreased in eyes with exudative CCH compared with age- and gender-controlled healthy eye group.Trial registration: This study was registered on the https://www.clinicaltrials.gov (trial registration number: NCT04449900)
BMSCs Seeding in Different Scaffold Incorporation with Hyperbaric Oxygen Treat Seawater Immersed Bony Defect
Authors: Zhang Gan , Chen Xiaosong , Cheng Xunsheng , Ma Xiuwu , Chen Congcong 
Published: July 2020

Abstract
Introduction: The experiment was undertaken to estimate the effect of BMSCs seeding in different scaffold incorporation with HBO on the repair of seawater immersed bone defect. And future compared n-HA/PLGA with β-TCP/PLGA as scaffold in treatment effect of seawater immersed bone defect.Methods: 60 New Zealand White rabbits with standard seawater defect in radius were randomly divided to group A (implant with nothing), group B (implanted with atuogenous bone), group C (implanted with n-HA/PLGA/BMSCs, and Group D ( implanted with β-TCP/PLGA/BMSCs). After implant, each rabbit receive HBO treatment at 2.4 ATA 100% oxygen for 120 minutes per day for 2 weeeks. Radiograph, histological and biomechanical examination were used to analyze osteogenesis.Result: X-ray analysis show that n-HA/PLGA/BMSCs and β-TCP/PLGA/BMSCs could accelerate the new bone formation, and the new bone formation in group C was lager than in group D or group A, and close to group B (P < 0.05). After 12 weeks, in group A, defect without scaffold show a loose connect tissue filled in the areas. The medullary canal in group B was recanalizated. Defect in group C and D show a larger number of wove bone formation. The new wove bone formation in defect areas in group C was lager than D. The mechanical examination revealed ultimate strength at 12 weeks were group D > group C > group B > group A(P < 0.05).Conclusion: Scaffold of n-HA/PLGA and β-TCP/PLGA incorporation with HBO and BMSCs were effective to treat seawater immersed bone defect, and n-HA/PLGA was more excellent than β-TCP/PLGA.
Multidrug resistant Enterobacteriaceae from blood stream infections at a tertiary care hospital of Eastern Nepal
Authors: Yadav Ajay , Bhattarai Narayan Raj , Khanal Basudha 
Published: July 2020

Abstract
Background
Blood stream infection (BSI) is one of the major causes of morbidity and mortality worldwide. It has poses significant challenge to the clinicians and clinical microbiologists alike. Therefore its accurate diagnosis, isolation and identification of causative agents with appropriate antibiotics is required. This study is aimed to find out resistance pattern, e.g. extended-spectrum-beta-lactamase (ESBL), AmpC, K1, carbapenemase and metallo-β-lactamase (MBL) among isolates obtained from BSI.
Methods
A cross-sectional study was conducted in the Department of Microbiology, BPKIHS from 1st September 2014 to 31st August 2015. Isolates were screened for ESBL, AmpC, K1, and carbapenemase production by ten disk method. Confirmation for ESBL was done phenotypically by using combined disk method recommended by CLSI, AmpC sterile disk method for AmpC and K1 by combined disk method. Metallo-beta-lactamase (MBL) production was detected by imipenem-ethylene-diamine-tetra acetic acid double disk synergy test.
Results
A total of 11,264 blood samples were collected from the patients suspected of Blood Stream Infection. Of these isolates, 192 (1.70%) were Enterobacteriaceae. Among them, 94 (49%) were ESBL, 51 (26.5%) were carbapenemase and 10 (5%) were AmpC producers. Of 51 carbapenemase producers, 22 (11.5%) were MBL producers. None of the isolates were found to produce K1 β-lactamase. A total of 64 (33.4%) isolates were MDR.
Conclusion
MDR Enterobacteriaceae is found to be prevalent in our set up as important cause of BSI.
Dielectric Nanohole Array Metasurface For High-Resolution Near-Field Sensing and Imaging
Authors: Conteduca Donato , Barth Isabel , Pitruzzello Giampaolo , Reardon Christopher , Martins Emiliano , Krauss Thomas 
Published: July 2020

Abstract
Dielectric metasurfaces support resonances that are widely explored both for far-field wavefront shaping and for near-field sensing and imaging. Their design explores the interplay between localised Mie resonances and extended Bragg resonances, with a typical trade-off between Q-factor and light localisation; high Q-factors are desirable for refractive index sensing while localisation is desirable for imaging resolution. Here, we show that a dielectric metasurface consisting of a nanohole array in amorphous silicon provides a favourable trade-off between these requirements. We have designed and realised the metasurface to support two optical modes both with sharp Fano resonances that exhibit relatively high Q factors and strong spatial confinement, thereby concurrently optimizing the device for both imaging and biochemical sensing. For the sensing application, we demonstrate a limit of detection (LOD) as low as 1pg/ml for Immunoglobulin G (IgG); for resonant imaging, we demonstrate a spatial resolution below 1µm and clearly resolve individual E.coli bacteria. The combined low LOD and high spatial resolution opens new opportunities for extending cellular studies into the realm of microbiology, e.g. for studying antimicrobial susceptibility.
Vibrational Couplings and Energy Transfer Pathways of Water’s Bending Mode
Authors: Yu Chun-Chieh , Chiang Kuo-Yang , Okuno Masanari , Seki Takakazu , Ohto Tatsuhiko , Yu XIaoqing , Korepanov Vitaly , Hamaguchi Hiro-o , Bonn Mischa , Hunger Johannes , Nagata Yuki 
Published: July 2020

Abstract
Coupling between vibrational modes is essential for energy transfer and dissipation in condensed matter. For water, different O-H stretch modes are known to be very strongly coupled both within and between water molecules, leading to ultrafast dissipation and delocalization of vibrational energy. In contrast, the information on the vibrational coupling of the H-O-H bending mode of water is lacking, even though the bending mode is an essential intermediate for the energy relaxation pathway from the stretch mode to the heat bath. By combining static and femtosecond infrared, Raman, and hyper-Raman spectroscopy with ab initio molecular dynamics simulations, we find the vibrational coupling of the bending mode differs significantly from the stretch mode: the intramode intermolecular coupling of the bending mode is very weak, in stark contrast to the stretch mode. Our results elucidate the vibrational energy transfer pathways of water. Specifically, the librational motion is essential for the vibrational energy relaxation and orientational dynamics of H-O-H bending mode.
Single-layered organic photovoltaics with double cascading charge transport pathways: 18 % efficiencies
Authors: Zhang Ming , Zhu Lei , Zhou Guanqing , Hao Tianyu , Qiu Chaoqun , Hu Qin , Larson Bryon , Feng Wei , Ma Zaifei , Tang Zheng , Zhu Haiming , Zhang Yongming , Russell Thomas , Liu Feng 
Published: July 2020

Abstract
The chemical structure of donors (Ds) and acceptors (As) limit the power conversion efficiencies (PCEs) achievable with bulk heterojunction (BHJ) active layers of binary D-A mixtures. However, using quaternary D-A blends, double cascading energy level alignment in BHJ organic photovoltaic active layers are realized, enabling efficient carrier splitting and transport. Numerous avenues to optimize light absorption, carrier transport, and charge transfer state energy levels are opened by the chemical constitution of the components. Record-breaking PCEs of 18.07% are achieved where, by electronic structure and morphology optimization, simultaneous improvements of the open-circuit voltage, short-circuit current and fill factor occur. The D and A chemical structures afford control over electronic structure and charge transfer state energy levels, enabling manipulation of hole-transfer rates, carrier transport, and non-radiative recombination losses.
Functional and Clinical Significance of ROR1 in Lung Adenocarcinoma
Authors: Schiavone Giovanna , Samantha Epistolio , Vittoria Martin , Francesca Molinari , Jessica Barizzi , Luca Mazzucchelli , Milo Frattini , Wannesson Luciano 
Published: July 2020

Abstract
BACKGROUND: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be overexpressed and associated with poor prognosis in several tumor models. This study aimed to assess the expression of ROR1 and verify its prognostic significance in lung adenocarcinoma (AC) patients.METHODS: We analyzed ROR1 expression by quantitative real-time PCR (qRT-PCR) in 56 histologically confirmed lung AC, stage I to IV, in addition we evaluated its association with TTF-1 (thyroid transcription factor-1) expression and the main molecular alterations involved in lung cancerogenesis.RESULTS: ROR1 overexpression was observed in 28.6% of the entire cohort, using a cut-off of 1, or in 51.8% of the cases using the median value as threshold. Among patients without any genetic alteration, ROR1 overexpression was observed in 34.8% considering a cut-off of 1 and 52.2% considering the median value. The distribution of ROR1 was homogeneous among the different molecular categories: we found no association of ROR1 expression and the presence of gene mutations/rearrangements or the expression of TTF-1. Furthermore, ROR1 expression was not correlated with overall survival (OS).CONCLUSIONS: ROR1 overexpression could constitute a potential therapeutic target because altered in a consistent number of lung AC, especially in cases without druggable genetic alterations. ROR1 expression is independent of classical lung cancer molecular alterations and not correlated, in a Caucasian cohort, to TTF-1 expression. Finally, ROR1 expression does not play a prognostic significance.
Self-Assembly Study of Type I Collagen Extracted from Male Wistar Hannover Rat Tail Tendons
Authors: González-Masís Jeimmy C. , Cubero-Sesin Jorge M. , Corrales-Ureña Yendry Regina , Guerrero Simón , González-Camacho Sara , Mora-Ugalde Nohelia , Vega-Baudrit José Roberto , Gonzalez-Paz Rodolfo J. 
Published: July 2020

Abstract
Background: Collagen is the main structural protein in the extracellular matrix in the numerous connective tissues in the body. As the main component of connective tissue, it is the most abundant protein in mammals. Method: Collagen Type I from Wistar Hannover rat tail was obtained and it allowed to describe the thermodynamic profile during self-assembly by isothermal titration calorimetry (Nano ITC) as a novel technique. Results: The enthalpy of self-assembly of the 0,01035 moles of collagen was 33,89 mJ; relevant data in tissue engineering and 3D collagen fibrils bio-impressions organs, with a periodicity of 65 nm were obtained and characterized. Conclusions: Calorimetric analysis shows higher energy release event at the isoelectric point of the protein, suggesting an overall exothermic process due to self-assembly of the collagen and an endothermic process due to aggregation of denatured collagen.
Capsid-like particles decorated with the SARS2-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Authors: Fougeoux Cyrielle , Goksøyr Louise , Idorn Manja , Soroka Vladislav , Myeni Sebenzile K. , Dagil Robert , Janitzek Christoph M. , Søgaard Teit , Aves Kara-Lee , Horsted Emma W. , Erdoğan Sayit Mahmut , Gustavsson Tobias , Dorosz Jerzy , Clemmensen Stine , Larsen Laurits , Thrane Susan , Vidal-Calvo Elena E. , Khalifé Paul , Hulen Thomas M. , Choudhary Swati , Theisen Michael , Singh Susheel , Garcia-Senosiain Asier , Oosten Linda Van , Pijlman Gorben , Hierzberger Bettina , Domeyer Tanja , Nalewajek Blanka W. , Strøbæk Anette , Skrzypczak Magdalena , Andersson Laura F. , Dalebout Tim , Iversen Kasper , Harritshøj Lene H. , Mordmüller Benjamin , Ullum Henrik , Reinert Line , de Jongh Willem Adriaan , Kikkert Marjolein , Paludan Soren , Theander Thor , Nielsen Morten , Salanti Ali , Sander Adam 
Published: July 2020

Abstract
The rapid development of a SARS-CoV-2 vaccine is a global priority. Here, we developed two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. RBD antigens were displayed on AP205 CLPs through a novel split-protein Tag/Catcher ensuring unidirectional and high-density display of RBD. Both soluble recombinant RBD, and RBD displayed on CLPs bound the ACE2 receptor with nanomolar affinity. Mice were vaccinated with soluble RBD or CLP-displayed RBD, formulated in Squalene-Water-Emulsion. The RBD-CLP vaccines induced higher levels of serum anti-RBD antibodies, than the soluble RBD vaccines. Remarkably, one injection with our lead RBD-CLP vaccine in mice elicited virus neutralization antibody titers comparable to those found in patients which had recovered from Covid-19. Following booster vaccinations, the virus neutralization titers exceeded those measured after natural infection, at serum dilutions above 1:10.000. Thus, the RBD-CLP vaccine is highly promising candidates for preventing COVID-19 disease.