bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species differences in ocular pharmacokinetics and pharmacological activities of regorafenib and pazopanib eye‐drops among rats, rabbits and monkeys
Authors: Horita Shinya , Watanabe Miwa , Katagiri Mai , Nakamura Hiroaki , Haniuda Hiroki , Nakazato Tomoyuki , Kagawa Yoshiyuki 
Published: November 2019

AbstractAge‐related macular degeneration (AMD) is the leading cause of severe vision impairment in patients over the age of 60 years. Choroidal neovascularization (CNV) is the hallmark of neovascular AMD and vascular endothelial growth factor (VEGF) plays a causal role in the formation of CNV. Although regorafenib and pazopanib, small molecule VEGF receptor (VEGFR) inhibitors, were developed as eye‐drops, their efficacies were insufficient in clinical. In this study, we evaluated ocular pharmacokinetics and pharmacological activities of regorafenib and pazopanib after ocular instillation in multiple animal species. In rats, both regorafenib and pazopanib showed high enough concentrations in the posterior eye tissues to inhibit VEGFR. In laser‐induced rat CNV model, regorafenib showed clear reduction in CNV area. On the other hand, the concentrations of regorafenib and pazopanib in the posterior eye tissues were much lower after ocular instillation in rabbits and monkeys compared to those in rats. Pazopanib did not show any improvement in monkey model. Regorafenib was nano‐crystalized to improve its drug delivery to the posterior eye tissues. The nano‐crystalized formulation of regorafenib showed higher concentrations in the posterior segments in rabbits compared to its microcrystal suspension. From these studies, large interspecies differences were found in ocular delivery to the posterior segments after ocular instillation. Such large interspecies difference could be the reason for the insufficient efficacies of regorafenib and pazopanib in clinical studies. Nano‐crystallization was suggested to be one of the effective ways to overcome this issue.
On the probabilistic skill of dual‐resolution ensemble forecasts
Authors: Leutbecher Martin , Ben Bouallègue Zied 
Published: November 2019

AbstractIncreasing spatial resolution and increasing ensemble size both tend to improve the skill of ensemble forecasts. Due to computational constraints, a balance needs to be found in operational NWP. Here, we examine a scenario where ensembles are formed by pooling lower‐resolution and higher‐resolution members such that the overall computational cost is equal to the constraint. The approach is applied to medium‐range weather forecasts with ECMWF's Integrated Forecasting System using horizontal resolutions of 18, 29 and 45 km and ensemble sizes ranging from 8 to 254 members. The methodology is similar to the multi‐level Monte‐Carlo approach but does not use stochastic perturbations that are shared between members at different levels. Probabilistic skill is quantified for 850 hPa temperature verified against analyses and 2 m temperature verified against station observations. Generally, dual‐resolution ensembles with similar numbers of lower and higher‐resolution members provide the optimal configuration for 2 m temperature prediction. In contrast, single‐resolution ensembles appear to be the most skilful for 850 hPa temperature. The dual‐resolution ensembles are a special kind of multi‐model ensemble. An analytic model describing the skill of such a multi‐model ensemble is developed and its parameters are estimated from the actual verification statistics. The model is capable of describing the general differences in behaviour between 2 m temperature and 850 hPa temperature.
Stem cells in skeletal muscle growth and regeneration in amniotes and teleosts: Emerging themes
Authors: Ruparelia Avnika A. , Ratnayake Dhanushika , Currie Peter D. 
Published: November 2019

AbstractSkeletal muscle is a contractile, postmitotic tissue that retains the capacity to grow and regenerate throughout life in amniotes and teleost. Both muscle growth and regeneration are regulated by obligate tissue resident muscle stem cells. Given that considerable knowledge exists on the myogenic process, recent studies have focused on examining the molecular markers of muscle stem cells, and on the intrinsic and extrinsic signals regulating their function. From this, two themes emerge: firstly, muscle stem cells display remarkable heterogeneity not only with regards to their gene expression profile, but also with respect to their behavior and function; and secondly, the stem cell niche is a critical regulator of muscle stem cell function during growth and regeneration. Here, we will address the current understanding of these emerging themes with emphasis on the distinct processes used by amniotes and teleost, and discuss the challenges and opportunities in the muscle growth and regeneration fields.This article is characterized under:
Adult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches
Early Embryonic Development > Development to the Basic Body Plan
Vertebrate Organogenesis > Musculoskeletal and Vascular
Universal local operator quenches and entanglement entropy
Authors: Bhattacharyya Arpan , Takayanagi Tadashi , Umemoto Koji 
Published: November 2019

Abstract
We present a new class of local quenches described by mixed states, parameterized universally by two parameters. We compute the evolutions of entanglement entropy for both a holographic and Dirac fermion CFT in two dimensions. This turns out to be equivalent to calculations of two point functions on a torus. We find that in holographic CFTs, the results coincide with the known results of pure state local operator quenches. On the other hand, we obtain new behaviors in the Dirac fermion CFT, which are missing in the pure state counterpart. By combining our results with the inequalities known for von-Neumann entropy, we obtain an upper bound of the pure state local operator quenches in the Dirac fermion CFT. We also explore predictions about the behaviors of entanglement entropy for more general mixed states.
Influence of Surface Anisotropy on Turbulent Flow Over Irregular Roughness
Authors: Busse Angela , Jelly Thomas O. 
Published: November 2019

AbstractThe influence of surface anisotropy upon the near-wall region of a rough-wall turbulent channel flow is investigated using direct numerical simulation (DNS). A set of nine irregular rough surfaces with fixed mean peak-to-valley height, near-Gaussian height distributions and specified streamwise and spanwise correlation lengths were synthesised using a surface generation algorithm. By defining the surface anisotropy ratio (SAR) as the ratio of the streamwise and spanwise correlation lengths of the surface, we demonstrate that surfaces with a strong spanwise anisotropy (SAR < 1) can induce an over 200% increase in the roughness function ΔU+, compared to their streamwise anisotropic (SAR > 1) equivalent. Furthermore, we find that the relationship between the roughness function ΔU+ and the SAR parameter approximately follows an exponentially decaying function. The statistical response of the near-wall flow is studied using a “double-averaging” methodology in order to distinguish form-induced “dispersive” stresses from their turbulent counterparts. Outer-layer similarity is recovered for the mean velocity defect profile as well as the Reynolds stresses. The dispersive stresses all attain their maxima within the roughness canopy. Only the streamwise dispersive stress reaches levels that are comparable to the equivalent Reynolds stress, with surfaces of high SAR attaining the highest levels of streamwise dispersive stress. The Reynolds stress anisotropy also shows distinct differences between cases with strong streamwise anisotropy that stay close to an axisymmetric, rod-like state for all wall-normal locations, compared to cases with spanwise anisotropy where an axisymmetric, disk-like state of the Reynolds stress anisotropy tensor is observed around the roughness mean plane. Overall, the results from this study underline that the drag penalty incurred by a rough surface is strongly influenced by the surface topography and highlight its impact upon the mean momentum deficit in the outer flow as well as the Reynolds and dispersive stresses within the roughness layer.
The Mechanism Underlying Change in the Sex Gap in Life Expectancy at Birth: An Extended Decomposition
Authors: Cui Qi , Canudas-Romo Vladimir , Booth Heather 
Published: November 2019

Abstract
The relationship between differential mortality rates and differences in life expectancy is well understood, but how changing differential rates translate into changing differences in life expectancy has not been fully explained. To elucidate the mechanism involved, this study extends existing decomposition methods. The extended method decomposes change in the sex gap in life expectancy at birth into three components capturing the effects of the sex difference in mortality improvement (ρ-effect), life table deaths density by age (f-effect), and remaining life expectancy by age (e-effect). These three effects oppose and augment each other, depending on relative change in sex-differential mortality rates. The new method is applied to period data for 35 countries and cohort data for 25 countries. The results demonstrate how the mechanism, involving the three effects, operates to determine change in the sex difference in life expectancy. We observe the pivotal importance of the f-effect, which is predominantly negative because of lower female mortality, in favoring narrowing rather than widening of the sex gap, in shifting the overall effect to younger ages, and in exaggerating fluctuations due to crisis mortality. The new decomposition provides a more detailed basis for substantive analyses examining change in differences in life expectancy.
Making a Mint: British Mercantile Influence and the Building of the Japanese Imperial Mint
Authors: Mizuta Susumu 
Published: November 2019

AbstractThe Japanese Imperial Mint, which began its operation producing gold and silver coins in Osaka in 1871, has come to represent the self-modernisation of Japanese architecture and society more generally, both in its industrial purpose and western classical style. This article focuses on the planning, construction and socio-spatial design of the mint to resituate the project in the context of British imperial expansion. New archival research in both Japan and Britain, enabling close analysis of overlooked drawings and documents, establishes the Japanese Imperial Mint's dependence on the transfer of men, machinery and plans from the former Hong Kong Mint, mediated and managed by the two firms Glover & Co and Jardine Matheson & Co. This article thus not only sheds new light on these two individually important buildings in colonial and imperial history, and the engineers involved, but illuminates the relationship between British colonial architecture and the activities of British merchants at the edge of empire in East Asia in the nineteenth century.
The revised Green et al., Paranoid Thoughts Scale (R-GPTS): psychometric properties, severity ranges, and clinical cut-offs
Authors: Freeman Daniel , Loe Bao S. , Kingdon David , Startup Helen , Molodynski Andrew , Rosebrock Laina , Brown Poppy , Sheaves Bryony , Waite Felicity , Bird Jessica C. 
Published: November 2019

AbstractBackgroundThe Green et al., Paranoid Thoughts Scale (GPTS) – comprising two 16-item scales assessing ideas of reference (Part A) and ideas of persecution (Part B) – was developed over a decade ago. Our aim was to conduct the first large-scale psychometric evaluation.MethodsIn total, 10 551 individuals provided GPTS data. Four hundred and twenty-two patients with psychosis and 805 non-clinical individuals completed GPTS Parts A and B. An additional 1743 patients with psychosis and 7581 non-clinical individuals completed GPTS Part B. Factor analysis, item response theory, and receiver operating characteristic analyses were conducted.ResultsThe original two-factor structure of the GPTS had an inadequate model fit: Part A did not form a unidimensional scale and multiple items were locally dependant. A Revised-GPTS (R-GPTS) was formed, comprising eight-item ideas of reference and 10-item ideas of persecution subscales, which had an excellent model fit. All items in the new Reference (a = 2.09–3.67) and Persecution (a = 2.37–4.38) scales were strongly discriminative of shifts in paranoia and had high reliability across the spectrum of severity (a > 0.90). The R-GPTS score ranges are: average (Reference: 0–9; Persecution: 0–4); elevated (Reference: 10–15; Persecution: 5–10); moderately severe (Reference: 16–20; Persecution:11–17); severe (Reference: 21–24; Persecution: 18–27); and very severe (Reference: 25+; Persecution: 28+). Recommended cut-offs on the persecution scale are 11 to discriminate clinical levels of persecutory ideation and 18 for a likely persecutory delusion.ConclusionsThe psychometric evaluation indicated a need to improve the GPTS. The R-GPTS is a more precise measure, has excellent psychometric properties, and is recommended for future studies of paranoia.
Interrelationships of factors of social development are more complex than Life History Theory predicts
Authors: Kotchoubey Boris 
Published: November 2019

Abstract
Life History Theory (LHT) predicts a monotonous relationship between affluence and the rate of innovations and strong correlations within a cluster of behavioral features. Although both predictions can be true in specific cases, they are incorrect in general. Therefore, the author's explanations may be right, but they do not prove LHT and cannot be generalized to other apparently similar processes.
The potentiality of sinking EDM for micro-impressions on Ti-6Al-4V: keeping the geometrical errors (axial and radial) and other machining measures (tool erosion and work roughness) at minimum
Authors: Ahmed Naveed , Anwar Saqib , Ishfaq Kashif , Rafaqat Madiha , Saleh Mustafa , Ahmad Shafiq 
Published: November 2019

AbstractTi-6Al-4V is a material of high interest in various industrial sectors including biomedical, automotive and aerospace. Conventional means of machining encounter different types of difficulties. Electric discharge machining (EDM) is not a contest of hardness. Circular impressions of micro-depth are produced in Ti-6Al-4V using four different electrode materials including aluminum, brass, graphite and copper, each assigned positive and negative polarity. In order to get precise control over the geometry of micro-impressions dimensional accuracy and tool wear must be controlled. Thus, EDM performance has been evaluated in terms of axial dimensional error (D.E_Axi), radial dimensional error (D.E_Rad), tool length reduction (TLR), and surface roughness (SR). Since the EDM process is stochastic in nature therefore in addition to tool polarity only two factors are considered as variables, i.e. discharge current and pulse-time-ratio (ration of on-time to off-time). The behaviors of each of the four electrode materials are compared together under each of the two polarities and two variables for each of the four response characteristics. The search is carried out to select the most appropriate tool electrode polarity (common for all responses) and a single common electrode capable of minimizing all the four response measures simultaneously. Moreover, microstructures of the machined impressions are discussed. Without any compromise in the minimum values of response measures, no single polarity and a single electrode are found common. However, with a slight compromise over the machining measures negative tool polarity and copper electrode served the purpose of set objectives (minimum of D.E, TLR, and SR). The expanse of compromise is found to be ≤ 50 µm in axial and radial dimensional errors, 0.8 µm in surface roughness and no compromise in tool length reduction if the copper electrode is assigned with negative polarity.
Effects of culling intensity on diel and seasonal activity patterns of sika deer (Cervus nippon)
Authors: Ikeda Takashi , Takahashi Hiroshi , Igota Hiromasa , Matsuura Yukiko , Azumaya Munemitsu , Yoshida Tsuyoshi , Kaji Koichi 
Published: November 2019

AbstractAdaptive hunting management is commonly used for controlling the populations of overabundant large herbivores; however, induced behavioural changes can make the effective control of target populations difficult. However, few studies have compared the impact of different levels of hunting intensities on the activity patterns of ungulates before, during, and after a culling program. We investigated how different culling intensities affect the activity patterns of sika deer on Nakanoshima Island in Lake Toya, Hokkaido, Japan using camera-trap surveys comparing the period of treatment before, during, and after a culling program. We used the number of deer photographed per hour per camera as an index of activity. Sika deer showed consistent crepuscular activity patterns (i.e., dawn and dusk) during spring–summer and trimodal activity patterns (i.e., dawn, dusk, and midnight) in autumn throughout the study period. In response to increased culling intensity, the activity peaks shifted slightly towards the night. The shift towards nocturnal activity persisted during post-culling period. Understanding the changes in activity patterns in response to culling intensity could be used to facilitate population control and assist in establishing a night shooting program. Thus, wildlife managers should consider night shooting once hunting during day time has shifted the normal diurnal activity of deer to nocturnal activity.
Rapidly and exactly determining postharvest dry soybean seed quality based on machine vision technology
Authors: Lin Ping , Xiaoli Li , Li Du , Jiang Shanchao , Zou Zhiyong , Lu Qun , Chen Yongming 
Published: November 2019

AbstractThe development of machine vision-based technologies to replace human labor for rapid and exact detection of agricultural product quality has received extensive attention. In this study, we describe a low-rank representation of jointly multi-modal bag-of-feature (JMBoF) classification framework for inspecting the appearance quality of postharvest dry soybean seeds. Two categories of speeded-up robust features and spatial layout of L*a*b* color features are extracted to characterize the dry soybean seed kernel. The bag-of-feature model is used to generate a visual dictionary descriptor from the above two features, respectively. In order to exactly represent the image characteristics, we introduce the low-rank representation (LRR) method to eliminate the redundant information from the long joint two kinds of modal dictionary descriptors. The multiclass support vector machine algorithm is used to classify the encoding LRR of the jointly multi-modal bag of features. We validate our JMBoF classification algorithm on the soybean seed image dataset. The proposed method significantly outperforms the state-of-the-art single-modal bag of features methods in the literature, which could contribute in the future as a significant and valuable technology in postharvest dry soybean seed classification procedure.
MicroRNA-132-3p suppresses type I IFN response through targeting IRF1 to facilitate H1N1 influenza A virus infection
Authors: Zhang Fangyi , Lin Xuefeng , Yang Xiaodong , Lu Guangjian , Zhang Qunmei , Zhang Chunxiao 
Published: November 2019

Abstract
Increasing evidence has indicated that microRNAs (miRNAs) have essential roles in innate immune responses to various viral infections; however, the role of miRNAs in H1N1 influenza A virus (IAV) infection is still unclear. The present study aimed to elucidate the role and mechanism of miRNAs in IAV replication in vitro. Using a microarray assay, we analyzed the expression profiles of miRNAs in peripheral blood from IAV patients. It was found that miR-132-3p was significantly up-regulated in peripheral blood samples from IAV patients. It was also observed that IAV infection up-regulated the expression of miR-132-3p in a dose- and time-dependent manner. Subsequently, we investigated miR-132-3p function and found that up-regulation of miR-132-3p promoted IAV replication, whereas knockdown of miR-132-3p repressed replication. Meanwhile, overexpression of miR-132-3p could inhibit IAV triggered INF-α and INF-β production and IFN-stimulated gene (ISG) expression, including myxovirus protein A (MxA), 2′,5′-oligoadenylate synthetases (OAS), and double-stranded RNA-dependent protein kinase (PKR), while inhibition of miR-132-3p enhanced IAV triggered these effects. Of note, interferon regulatory factor 1 (IRF1), a well-known regulator of the type I IFN response, was identified as a direct target of miR-132-3p during HIN1 IAV infection. Furthermore, knockdown of IRF1 by si-IRF1 reversed the promoting effects of miR-132-3p inhibition on type I IFN response. Taken together, up-regulation of miR-132-3p promotes IAV replication by suppressing type I IFN response through its target gene IRF1, suggesting that miR-132-3p could represent a novel potential therapeutic target of IAV treatment.
Linsenchirurgie: Einsatz von multifokalen Intraokularlinsen
Authors: Shajari Mehdi , Mayer Wolfgang J. , Priglinger Siegfried 
Published: November 2019

ZusammenfassungDer Austausch der natürlichen Linse mittels einer künstlichen Intraokularlinse gehört zu den weltweit am häufigsten durchgeführten Operationen. In diesem Artikel werden die gängigsten multifokalen Linsen zusammengefasst und die wichtigsten Aspekte für den klinischen Alltag dargestellt.
Tibiapseudarthrosen
Authors: Hessmann Martin Henri , Körblein Katharina 
Published: November 2019

ZusammenfassungPseudarthrosen gehören zu den häufigsten Komplikationen nach Tibiaschaftfrakturen. Hypertrophe Pseudarthrosen erfordern eine Verbesserung der biomechanischen Stabilitätseigenschaften der Osteosynthese. Der Verfahrenswechsel mit Umnagelung und die augmentierende Plattenosteosynthese bieten verlässlich gute Ausheilungsergebnisse. Bei der atrophen Pseudarthrose sind zusätzliche Maßnahmen zur Verbesserung der Biologie erforderlich. Infektpseudarthrosen sind besonders anspruchsvoll und erfordern die Therapie sowohl des Infektes als auch der Frakturheilungsstörung. Die sorgfältige Analyse der Ausgangssituation und der Ursachen der Frakturheilungsstörung sowie die konsequente Therapie führen zu hohen Ausheilungsraten.