bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jackhammer esophagus: Clinical presentation, manometric diagnosis, and therapeutic results—Results from a multicenter French cohort
Authors: Philonenko Sara , Roman Sabine , Zerbib Frank , Gourcerol Guillaume , Gault Nathalie , Ropert Alain , Bruley des Varannes Stanislas , Barret Maximilien , Vitton Veronique , Bouchoucha Michel , Billard Nicolas , Gorbatchef Caroline , Duboc Henri , Coffin Benoit 
Published: June 2020

AbstractBackground/aimsJackhammer esophagus (JE) is a hypercontractile esophageal motor disorder defined by at least two swallows with a distal contractile integral (DCI) >8000 mm Hg.s.cm during high‐resolution manometry (HRM). The relationship between symptoms and hypercontractility and the response to therapies have been poorly evaluated. The aim of this study was to determine the clinical presentation, manometric diagnosis, and therapeutic results in a large cohort of JE patients.MethodsPatients with JE diagnosed among the HRM tests performed in nine academic French centers from 01/01/2010 to 08/31/2016 were included. Patient charts were reviewed to collect clinical and therapeutic data.ResultsAmong the 16 264 HRM tests performed during this period, 227 patients (60.8 ± 13.8 years, 151 male) had JE (1.7%). Dysphagia was the most frequent symptom (74.6%), followed by regurgitation (37.1%) and chest pain (36.6%); 4.7% of the patients were asymptomatic. The diagnostic workup was heterogeneous, and only a minority of patients had esophageal biopsies. None of the individual symptoms were significantly associated with any of the manometric parameters defined, except for dysphagia, which was significantly associated with the mean of all DCIs >8000 mm Hg.s.cm (P = .04). Additionally, the number of symptoms was not associated with any manometric parameter. Medical treatment and endoscopic treatments had poor efficacy and a high relapse rate.ConclusionJackhammer esophagus is a rare motility disorder. Diagnostic workup is heterogeneous and should be standardized. Symptoms are poorly associated with manometric parameters. The medical treatments and endoscopic therapies currently used are inefficient.
Direct Anterior Approach in Crowe Type III‐IV Developmental Dysplasia of the Hip: Surgical Technique and 2 years Follow‐up from Southwest China
Authors: Liu Zai‐yang , Zhang Jun , Wu Song‐tao , Li Zi‐qiang , Xu Zhong‐hua , Zhang Xia , Zhou Yue , Zhang Yuan 
Published: June 2020

ObjectivesTo summarize our pioneering surgical practice and clinical outcome of Crowe type III‐IV developmental dysplasia of the hip (DDH) with a direct anterior approach total hip arthroplasty in a single teaching hospital in Southwest China.MethodsFourteen patients (15 hips) diagnosed with Crowe type III‐IV developmental dysplasia of the hip were involved in this single‐center retrospective study between 2016 and 2018. A comprehensive surgical procedure, including preoperative planning and algorithms for leg length equalization, intraoperative stepwise soft tissue release, bone defect reconstruction, and an innovative subtrochanteric osteotomy, was described. Furthermore, advancements in intraoperative CT guidance, computer navigation, and nerve monitoring were available for specific demands. The short‐term clinical outcome was evaluated at the endpoint of follow‐up by three patient‐reported functional scales (Harris, WOMAC, and SF‐12 scores), and objective data collected at the clinic, including functional recovery (muscle strength of hip flexor and abductor, correction of the pelvic tilt, leg length discrepancy, and limp), radiographic analysis, and complication occurrence.ResultsThe intraoperative variables were carefully recorded. The mean operating times in Crowe type III and IV groups were 115.8 min and 156.2 min, and the median blood loss volumes were 520.5 mL and 810.2 mL, respectively. The general changes in the Harris, SF‐12, and WOMAC scores of the two groups were 46.2, 8.7 and 134.3, respectively, at a mean follow‐up of 25.4 months. Enhanced recovery of hip abductor muscle strength was identified in 85.7% of the population at the third postoperative month. The equalization of leg length and correction of the pelvic tile were observed at the sixth postoperative month, with a 36‐mm decrease in leg length discrepancy. No radiographic evidence of the loosening or migration of the components was observed. A self‐innovated subtrochanteric shortening osteotomy was performed in five patients, and they healed after 6 months. Specific complications included two cases of distal femoral cracks and one case of a periprosthetic fracture needing internal fixation. Two patients received a late iliotibial band release at the 3rd month postoperatively due to progressive genu valgum. No records of infection, dislocation, nerve palsy, bone non‐union, or revision surgery were identified.DiscussionThe direct anterior approach total hip arthroplasty showed potential advantages, including optimum component positioning, improved hip stability, steerable complication rate, and enhanced functional recovery with Crowe type III‐IV DDH. The short‐term outcome is comparable to that of the traditional posterolateral approach.
Cryoballoon or radiofrequency ablation? Alternating technique for repeat procedures in patients with atrial fibrillation
Authors: Verlato Roberto , Pieragnoli Paolo , Iacopino Saverio , Rauhe Werner , Molon Giulio , Stabile Giuseppe , Rebellato Luca , Allocca Giuseppe , Arena Giuseppe , Rovaris Giovanni , Sacchi Riccardo , Catanzariti Domenico , Pepi Patrizia , Tondo Claudio 
Published: June 2020

AbstractBackgroundWhich technique is better for repeat ablation in patients with atrial fibrillation (AF) remains unclear. The aim of the study was to compare long‐term efficacy of repeat ablation using the alternative technique for the first redo ablation procedure: (a) cryoballoon (CB) re‐ablation after a failed index pulmonary vein isolation (PVI) with radiofrequency (RF) ablation, RF‐then‐CB group or (b) RF repeat ablation following a failed CB ablation, CB‐then‐RF group.MethodsWithin the 1STOP Italian Project, consecutive patients undergoing repeat ablation with a different technique from the index procedure were included.ResultsWe studied 474 patients, 349 in RF‐then‐CB and 125 in CB‐then‐RF group. Less women (21% vs 30%; P = .041), more persistent AF (33% vs 22%; P = .015), longer duration of AF (60 vs 31 months; P < .001), and more hypertension (50% vs 36%; P = .007) were observed in the RF‐then‐CB cohort as compared with the CB‐then‐RF group. The number of reconnected PVs was 3.7 ± 0.7 and 1.4 + 1.3 in RF‐then‐CB and CB‐then‐RF group, respectively (P < .001). During the follow‐up, significantly less AF recurrence occurred in the CB‐then‐RF group (22% vs 8%, HR = 0.46; 95% CI: 0.24‐0.92; P = .025). Cohort designation was the only independent predictor of AF recurrence.ConclusionAlternation of energy source for repeat ablation was safe and effective, regardless the energy used first. However, patients initially treated with CB PVI undergoing repeat ablation with RF current had less AF recurrence at long‐term follow‐up as compared with those originally treated by RF ablation receiving a CB repeat ablation.
Personal brand equity: Scale development and validation
Authors: Gorbatov Sergey , Khapova Svetlana N. , Oostrom Janneke K. , Lysova Evgenia I. 
Published: June 2020

AbstractCrafting a personal brand has become an important factor for career success. Despite the growing literature on topics associated with personal brands, the conceptualization and measurement of personal brand equity (PBE) have received little attention. By drawing upon and integrating the marketing and careers literatures on branding, we reconceptualized the definition of PBE and delineated its dimensions and conceptual boundaries. Furthermore, we developed a 12‐item scale to measure PBE. Among seven different samples (total N = 3,273), including two samples of employees, this study tested the construct and criterion‐related validity of the PBE scale. First, exploratory and confirmatory factor analyses supported a three‐dimensional structure of PBE (brand appeal, brand differentiation, and brand recognition). In two samples, the convergent and discriminant validity of the PBE scale was established. Finally, this study showed that PBE predicts perceived employability, career success, and job performance. The PBE scale offers new opportunities to understand and measure career behaviors by considering individuals’ personal brand positioning.
Hyponatremia: A possible immuno‐neuroendocrine interface with COVID‐19 in a kidney transplant recipient
Authors: Tantisattamo Ekamol , Reddy Uttam G. , Duong Dang K. , Ferrey Antoney J. , Ichii Hirohito , Dafoe Donald C. , Kalantar‐Zadeh Kamyar 
Published: June 2020

AbstractThere is fast‐emerging, cumulative clinical data on coronavirus disease 2019 (COVID‐19) in kidney transplant recipients. Although respiratory tract symptoms are often the initial presentation among kidney transplant recipients who contract COVID‐19, other clinical features which may indicate underlying SARS‐CoV‐2‐related inflammation, such as gastrointestinal symptoms, are not uncommon. Hyponatremia can develop and may reflect underlying inflammation. Interferon‐6 is an important pro‐inflammatory cytokine involved in the pathogenesis of severe COVID‐19 complications and may play a role in the inappropriately higher secretion of antidiuretic hormone leading to hyponatremia. This pathway is the so‐called immuno‐neuroendocrine interface. Hyponatremia in COVID‐19 has been reported in a few case series of non‐kidney transplant patients and only one reported kidney transplant recipient. However, the clinical course and prognostic value of hyponatremia in this population are not described in detail. We report a kidney transplant recipient who was infected with COVID‐19 and exhibited severe hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion. Hyponatremia is one of the clinical presentations of COVID‐19, although less common, and may occur more frequently in kidney transplant recipients. Thus, the possible underlying immuno‐neuroendocrine relationship related to the inflammatory process of COVID‐19 leading to hyponatremia and its prognostic value are reviewed.
COVID‐19 in lung transplant recipients: A case series from Milan, Italy
Authors: Morlacchi Letizia Corinna , Rossetti Valeria , Gigli Lorenzo , Amati Francesco , Rosso Lorenzo , Aliberti Stefano , Nosotti Mario , Blasi Francesco 
Published: June 2020

AbstractLimited data are currently available regarding the course of COVID‐19 in lung and solid organ transplant recipients. We hereby present four cases of SARS‐CoV‐2 pneumonia in lung transplant recipients from our center, set in Milan, Italy. We reduced immunosuppressive regimen in all these patients, typically holding the antiproliferative agent and augmenting steroids; everybody received hydroxychloroquine, initial empiric antibiotic treatment with piperacillin/tazobactam, and high‐dose low molecular weight heparin. Clinical course seemed favorable in three of our patients, but one of them deteriorated after 10 days of hospitalization, probably due to an acute form of graft dysfunction triggered both by COVID‐19 and a nosocomial bacterial infection, and eventually died. Although short‐term prognosis could be considered benign in the majority of our patients, we should carefully monitor these individuals in order to detect early sign of clinical deterioration and graft dysfunction in the next few months.
Tuberculosis transmission across three states: The story of a solid organ donor born in an endemic country, 2018
Authors: Jones Jefferson M. , Vikram Holenarasipur R. , Lauzardo Michael , Hill Amy , Jones Jeffrey , Haley Clinton , Seaworth Barbara , Oldham Sara , Brown Marcus , Gutierrez Felipe , Basavaraju Sridhar V. 
Published: June 2020

AbstractTransmission of tuberculosis (TB) from a deceased solid organ donor to recipients can result in severe morbidity and mortality. In 2018, four solid organ transplant recipients residing in three states but sharing a common organ donor were diagnosed with TB disease. Two recipients were hospitalized and none died. The organ donor was born in a country with a high incidence of TB and experienced 8 weeks of headache and fever prior to death, but was not tested for TB during multiple hospitalizations or prior to organ procurement. TB isolates of two organ recipients and a close contact of the donor had identical TB genotypes and closely related whole‐genome sequencing results. Donors with risk factors for TB, in particular birth or residence in countries with a higher TB incidence, should be carefully evaluated for TB.
An open‐label dose escalation study evaluating tolerability and safety of a single 5‐days course of temozolomide in dogs with advanced cancer
Authors: Marconato Laura , Rohrer Bley Carla , Leone Vito F. , Finotello Riccardo 
Published: June 2020

AbstractTemozolomide is a novel oral alkylating agent that has schedule‐dependent clinical activity in human malignant glioma and metastatic melanoma. Little is known about the efficacy of temozolomide in the treatment of canine solid cancers, where broad range of dosages have been used but no maximally tolerated dose (MTD) had been established. The aim of this this open‐label, dose‐escalating study was to determine MTD and dose‐limiting toxicity (DLT) of a single temozolomide cycle in dogs with advanced solid tumours. Temozolomide was administered as a 5‐days course starting at 70 mg/m2, using escalation of 10 mg/m2 increments with 3 dogs per dose level. MTD was established based on the number of dogs experiencing DLT assessed after 1 cycle. Safety evaluation was performed 10 days after dosing. Thirty‐three client‐owned dogs were enrolled. MTD was established at 150 mg/m2 and the most frequent adverse events (AEs) were hematologic and hepatic, followed by gastrointestinal, with the majority being self‐resolving and of mild grade. VCOG grade 3 hepatic toxicity and grade 4 thrombocytopenia were defined as DLTs at 160 mg/m2. A subcohort of dogs received multiple temozolomide doses on a 4‐week cycle and no cumulative toxicity was documented. Conclusions of this study define temozolomide MTD at 150 mg/m2 when given once daily over 5 days. Future trials on the efficacy of temozolomide administered at its MTD are warranted.
Evaluation of the short‐ and long‐term complications and outcomes of phacoemulsification surgery in alpacas
Authors: Ledbetter Eric C. , Irby Nita L. 
Published: June 2020

AbstractObjectiveTo describe the complications and determine the visual outcomes associated with phacoemulsification surgery in alpacas.AnimalsFive alpacas (nine operated eyes).ProceduresMedical records of alpacas with a clinical diagnosis of cataracts that received elective phacoemulsification surgery at Cornell University over a 15 year period were reviewed.ResultsThe mean (± standard deviation) age of the five operated alpacas was 104 days (±64 days). The cataracts were suspected to be congenital in all alpacas. Concurrent congenital ocular abnormalities were common in the operated eyes and included microphakia, persistent patent hyaloid arteries, and persistent patent tunica vasculosa lentis. No significant intraoperative complications were identified in any cases. In the immediate postoperative period, uveitis was mild‐to‐moderate in most operated eyes, ocular hypertension was not detected, and clinically significant corneal edema did not occur in any eyes. The mean (± standard deviation) duration of clinical follow‐up after surgery was 32 months (±25 months). A peri‐incisional corneal stromal ulcer associated with fibrinous uveitis was identified in a single eye during recheck examination 4 weeks postoperative that resolved with medical therapy. Long‐term complications included unilateral glaucoma in two alpacas that resulted in vision loss. On the final recheck ophthalmic examination, 78% (7 of 9) of operated eyes were visual and all operated alpacas had vision in at least one operated eye.Conclusions and clinical relevanceIn this series, the visual outcomes associated with elective phacoemulsification surgery in alpacas were good. Glaucoma was the most common vision‐threatening long‐term postoperative complication.
Integration of Modeling Capabilities in CATHENA for Supercritical Water Reactors
Authors: Beuthe T. , Vasić A. , Zahlan H. , Nava Domínguez A. 
Published: June 2020

Abstract
CATHENA has been successfully employed to simulate accident and startup transients in the development of the Canadian supercritical water reactor concept. This success is attributed to the implementation of a novel method to integrate supercritical modeling elements into the code. A supercritical water properties scheme was used that does not rely on the use of pseudo-phases and treats the supercritical regime as a single uninterrupted phase. The development of a robust numerical strategy manages the transitions that can occur in accident scenarios. Finally, the utilization of an expanded transcritical heat transfer look-up-table that smoothly transitions across the near-critical and supercritical regions over a wide temperature range ensures consistent, stable simulation results.
Incipient evolution of the Eastern California shear zone through the transpressional zone of the San Bernardino Mountains and San Gorgonio Pass, California
Authors: Cochran William J. , Spotila James A. , Prince Philip S. 
Published: June 2020

AbstractThe nature of the connection between the Eastern California shear zone (ECSZ) and the San Andreas fault (SAF) in southern California (western United States) is not well understood. Northwest of San Gorgonio Pass, strands of the ECSZ may be migrating south and west into the convergent zone of the San Bernardino Mountains (SBM) as it is advected to the southeast via the SAF. Using high-resolution topography and field mapping, this study aims to test whether diffuse faults within the SBM represent a nascent connection between the ECSZ and the SAF. Topographic resolution of ≤1 m was achieved using both lidar and unmanned aerial vehicle surveys along two Quaternary strike-slip faults. The Lone Valley fault enters the SBM from the north and may form an along-strike continuation of the Helendale fault. We find that its geomorphic expression is obscured where it crosses Quaternary alluvium, however, suggesting that it may have a low rate of yet-undetermined activity. The Lake Peak fault is located farther south and cuts through the high topography of the San Gorgonio massif and may merge with strands of the SAF system. We find that this fault clearly cuts Quaternary glacial deposits, although the magnitude of offset is difficult to assess. Based on our interpretation of geomorphic features, we propose that the Lake Peak fault has predominantly dextral or oblique-dextral motion, possibly with a slip rate that is comparable to the low rates observed along other strands of the ECSZ (i.e., ≤1 mm/yr). Comparing the geomorphic expressions of these faults is difficult, however, given that the erosive nature of the mountainous landscape in the SBM may obscure evidence of active faulting. Based on these observations, as well as the occurrence of other diffuse faults in the region, we suggest that dextral strain is overprinting the actively convergent zone of the SBM, thereby creating a throughgoing connection between the ECSZ and the SAF west of San Gorgonio Pass.
Three-dimensional shape and structure of the Susitna basin, south-central Alaska, from geophysical data
Authors: Shah Anjana K. , Phillips Jeffrey D. , Lewis Kristen A. , Stanley Richard G. , Haeussler Peter J. , Potter Christopher J. 
Published: June 2020

AbstractWe use gravity, magnetic, seismic reflection, well, and outcrop data to determine the three-dimensional shape and structural features of south-central Alaska’s Susitna basin. This basin is located within the Aleutian-Alaskan convergent margin region and is expected to show effects of regional subduction zone processes. Aeromagnetic data, when filtered to highlight anomalies associated with sources within the upper few kilometers, show numerous linear northeast-trending highs and some linear north-trending highs. Comparisons to seismic reflection and well data show that these highs correspond to areas where late Paleocene to early Eocene volcanic layers have been locally uplifted due to folding and/or faulting. The combined magnetic and seismic reflection data suggest that the linear highs represent northeast-trending folds and north-striking faults. Several lines of evidence suggest that the northeast-trending folds formed during the middle Eocene to early Miocene and may have continued to be active in the Pliocene. The north-striking faults, which in some areas appear to cut the northeast-trending folds, show evidence of Neogene and probable modern movement. Gravity data facilitate estimates of the shape and depth of the basin. This was accomplished by separating the observed gravity anomaly into two components—one representing low-density sedimentary fill within the basin and one representing density heterogeneities within the underlying crystalline basement. We then used the basin anomaly, seismic reflection data, and well data to estimate the depth of the basin. Together, the magnetic, gravity, and reflection seismic analyses reveal an asymmetric basin comprising sedimentary rock over 4 km thick with steep, fault-bounded sides to the southwest, west, and north and a mostly gentle rise toward the east. Relations to the broader tectonic regime are suggested by fold axis orientations within the Susitna basin and neighboring Cook Inlet basin, which are roughly parallel to the easternmost part of the Alaska-Aleutian trench and associated Wadati-Benioff zone as it trends from northeast to north-northeast to northeast. An alignment between forearc basin folds and the subduction zone trench has been observed at other convergent margins, attributed to strain partitioning generated by regional rheologic variations that are associated with the subducting plate and arc magmatism. The asymmetric shape of the basin, especially its gentle rise to the east, may reflect uplift associated with flat-slab subduction of the Yakutat microplate, consistent with previous work that suggested Yakutat influence on the nearby Talkeetna Mountains and western Alaska Range. Yakutat subduction may also have contributed to Neogene and later reverse slip along north-striking faults within the Susitna basin.
Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA
Authors: Pécriaux Adrien , Favre Loetitia , Calderaro Julien , Charpy Cécile , Derman Jonathan , Pujals Anaïs 
Published: June 2020

AimDuring the last few years, determination of microstatellite instability (MSI) status has become a routine part of clinical practice, essentially to detect Lynch syndrome. Recently, MSI testing has increased with the development of immunotherapy and has expanded to a large panel of solid tumours. The aim of our work was to evaluate a fully automated system developed by Biocartis, the Idylla MSI Test, which performs an MSI analysis within 150 min.MethodsA comparison between pentaplex PCR, immunohistochemistry and Idylla MSI Test was performed in 53 colorectal carcinoma samples, 7 small intestine adenocarcinomas, 15 duodenal and pancreatic adenocarcinomas, 16 gastric tumours, 15 endometrial adenocarcinomas, 5 ovarian carcinomas and 4 cases of urinary tract tumours using extracted DNA. Limit-of-detection (LOD) experiment was also done using a commercial DNA known to harbour MSI phenotype.ResultsThe overall sensitivity was 94% and the overall specificity was 100%. Two invalid and three false-negative results were observed. Our experiments showed that the amount of DNA loaded into the cartridge was decisive and should be superior to 25 ng. LOD comprised between 4% and 8%.ConclusionOverall, we have demonstrated that the Idylla MSI Test is a rapid and valid option to detect MSI phenotype which can be used in a large panel of solid tumours.