bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reevaluating the prudence of economic forecasts in the EU: The role of instrument persistence
Authors: Demetrescu Matei , Roling Christoph , Titova Anna 
Published: November 2020

SummaryChristodoulakis and Mamatzakis (2009, Journal of Applied Econometrics 24, pp. 583–606) estimate the EU Commission loss preferences for selected economic forecasts of 12 EU Member States. They employ the generalized method of moments (GMM) estimation procedure proposed by Elliott et al. (2005, Review of Economic Studies 72, pp. 1107–1125) and find the forecasts to be somewhat optimistic on average. However, this note shows the GMM estimator to possess nonstandard limiting distributions when some of the instruments are highly persistent, which is the case with one of the instruments employed by Christodoulakis and Mamatzakis. Standard distributions are recovered in some interesting particular cases which are relevant in practice. A reexamination of the EU Commission loss preferences using methods robust to persistence and a dataset extended to 2017 reveals that, while the conclusions of the original study are, by and large, still justified, the EU Commission loss preferences have become more symmetric over the whole studied period.
Voltage‐dependent conformational changes of Kv1.3 channels activate cell proliferation
Authors: Cidad Pilar , Alonso Esperanza , Arévalo‐Martínez Marycarmen , Calvo Enrique , de la Fuente Miguel A. , Pérez‐García M. Teresa , López‐López José R. 
Published: November 2020

AbstractThe voltage‐dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for proliferation suggests the involvement of molecule‐specific interactions, but the underlying mechanisms are poorly identified. Heterologous expression of Kv1.3 channels in HEK cells has been shown to increase proliferation independently of K+ fluxes. Likewise, some of the molecular determinants of Kv1.3‐induced proliferation have been located in the C‐terminus region, where individual point mutations of putative phosphorylation sites (Y447A and S459A) abolished Kv1.3‐induced proliferation. Here, we investigated the mechanisms linking Kv1.3 channels to proliferation exploring the correlation between Kv1.3 voltage‐dependent molecular dynamics and cell cycle progression. Using transfected HEK cells, we analyzed both the effect of changes in resting membrane potential on Kv1.3‐induced proliferation and the effect of mutated Kv1.3 channels with altered voltage dependence of gating. We conclude that voltage‐dependent transitions of Kv1.3 channels enable the activation of proliferative pathways. We also found that Kv1.3 associated with IQGAP3, a scaffold protein involved in proliferation, and that membrane depolarization facilitates their interaction. The functional contribution of Kv1.3‐IQGAP3 interplay to cell proliferation was demonstrated both in HEK cells and in vascular smooth muscle cells. Our data indicate that voltage‐dependent conformational changes of Kv1.3 are an essential element in Kv1.3‐induced proliferation.
Titanium dioxide doped hydroxyapatite incorporated photocatalytic membranes for the degradation of chloramphenicol antibiotic in water
Authors: Singh Anirudh , Ramachandran Sathish Kumar , Gumpu Manju Bhargavi , Zsuzsanna Laszlo , Veréb Gábor , Kertész Szabolcs , Gangasalam Arthanareeswaran 
Published: November 2020

AbstractBACKGROUNDIn the recent years, photocatalytic membrane process has gained interest in wastewater treatment applications. In this study, the ability of advanced oxidation technology coupled membrane process was evaluated during chloramphenicol (CAP) filtration. Titanium dioxide doped hydroxyapatite (TiO2‐HAP) based photocatalytic membrane for chloramphenicol (CAP) degradation was investigated. The TiO2‐HAP photocatalyst was synthesized by a facile hydrothermal technique and characterized by the transmission electron microscope, X‐ray diffraction, and FTIR spectroscopy. Varying concentrations of TiO2‐HAP photocatalyst incorporated polysulfone (PSf) membranes were fabricated to enhance the photocatalytic activity and antifouling propensity. The photocatalytic activity of TiO2‐HAP incorporated PSf membranes was evaluated by a low‐pressure cross‐flow lab‐scale photocatalytic membrane reactor (PMR) for degradation of chloramphenicol in water. These results were compared with pristine PSf membrane.RESULTSThe degradation of chloramphenicol was measured by liquid chromatography‐mass spectrometry (LC–MS). The photocatalytic degradation experiments revealed that the highest degradation of 61.59% was observed for the PSf/4 wt% TiO2‐HAP nanocomposite membrane.CONCLUSIONThis study highlights the advantages of applying the photocatalytic TiO2‐HAP incorporated PSf composite membranes for pharmaceutical wastewater treatment applications. © 2020 Society of Chemical Industry
The inhibition of enterovirus 71 induced apoptosis by Durvillaea antarctica through P53 and STAT1 signaling pathway
Authors: Xu Tiantian , Li Yinghua , Wu Hua‐lian , Chen Haiyang , Wu Houbo , Guo Min , Zhao Mingqi , Wang Changbing , Lin Tao , Lin Zhengfang , Chen Danyang , Xiang Wenzhou , Zhu Bing 
Published: November 2020

AbstractThe infection of enterovirus 71 (EV71) resulted in hand, foot, and mouth disease and may lead to severe nervous system damage and even fatalities. There are no effective drugs to treat the EV71 virus and it is crucial to find novel drugs against it. Polysaccharide isolated from Durvillaea antarctica green algae has an antiviral effect. In this study, D. antarctica polysaccharide (DAPP) inhibited the infection of EV71 was demonstrated by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT), reverse transcription polymerase chain reaction, flow cytometry, and western blot. MTT assay showed that DAPP had no toxicity on Vero cells at the concentration 250 μg/ml. Furthermore, DAPP significantly reduced the RNA level of EV71 in a dose‐dependent manner. Moreover, DAPP inhibited the Vero cells apoptosis induced by EV71 via the P53 signaling pathway. Meanwhile, the expression of signal transducer and activator of transcription 1 and mammalian target of rapamycin were increased and the proinflammatory cytokines were significantly inhibited by DAPP. Taken together, these results suggested that DAPP could be a potential pharmaceutical against the infection of EV71 virus.
Optimal potassium management strategy to enhance crop yield and soil potassium fertility under paddy‐upland rotation
Authors: Zhu Dandan , Zhang Jianglin , Lu Jianwei , Cong Rihuan , Ren Tao , Li Xiaokun 
Published: November 2020

AbstractBACKGROUNDAn unbalanced application of potassium (K) fertilizer usually destabilizes crop yield and affects soil K fertility. Developing a sustainable K management strategy requires improvements in crop yield without reducing soil K supply capacity over the long term. A combination of field experiments of K fertilization and straw return using rice (Oryza sativa L.)–oilseed rape (Brassica napus L.) rotation was designed to develop an optimal K management strategy.RESULTSThe results showed the best strategy to maintain yield was KG+S (input equivalent K removed by seed treatment and straw return), KS+KG (input equivalent K removed by straw and seed) and KC+S (conventional K fertilization and straw return) treatments, and the yield gap among different treatments expanded with the extension of planting years. There were significant differences present in rice and rape K uptake, although no differences in seed K uptake were observed under different K management strategies. The K balance was approximately maintained under KG+S and KS+KG treatments, and negative K balances were present for KN (no K application), KC (conventional fertilization), +S (straw return) and KS treatments (input equivalent K that removed by straw treatment). A positive balance was observed under KC+S treatment. Slight changes in soil exchangeable and nonexchangeable K were observed under KG+S and +S treatments. However, high inputs of K fertilizer prevented the improvement of agronomic efficiency and recovery efficiency of K.CONCLUSIONSIn summary, the optimal K management strategy was KG+S, which stabilizes the crop yield, maintains soil K fertility and maximizes K use efficiency. © 2020 Society of Chemical Industry
High luminance and high see‐through head‐mounted displays with beam‐splitter‐array waveguides
Authors: Ukai Ryuji , Kuno Takuma , Nakamura Toshiteru , Uchiyama Masahito , Ouchi Satoshi 
Published: November 2020

AbstractWe have developed head‐mounted displays with high transmittance and luminance, which could be utilized outside safely without dimming glasses. We first specified required optical performance specifications by considering user's safety and usability. In order to ensure that the user is able to recognize both surrounding environment and the image of the head‐mounted display, we set the target specification that the transmittance is higher than or equal to 85%, and the luminance contrast ratio is larger than or equal to 1.15 with display image of white solid pattern. We then developed the beam‐splitter‐array waveguide to achieve the requirements. It has advantages in high efficiency and high see‐through property. In order to determine configuration of the waveguide, we have performed optical ray trace simulation. We also established versatile waveguide measurement method applicable to different‐type waveguides. By utilizing the waveguide we have developed, we made a prototype of a head‐mounted display (HMD) with high transmittance 94% and high luminance 4.8 × 103 cd/m2 and thus luminance contrast ratio 1.25 under the sun. With these advantages, our HMD is suitable for usage outside including applications of work support systems where dimming effect is not preferred, and the HMD is used under the sun.
New liquid chromatography assays for simultaneous quantification of antihypertensives atenolol and valsartan in their dosage forms
Authors: Peleshok Kateryna , Piponski Marjan , Kovalenko Sergiy , Ahmed Hytham , Abdel‐Megied Ahmed , Ezike Obianuju Florence , Logoyda Liliya 
Published: November 2020

AbstractNowadays, various single‐pill combinations are used as the best choice in hypertension management. However, these pills made a high challenge to analysts in terms of quality control assays. We have developed three sensitive, selective, fast, simple, green, accurate, precise, and robust isocratic high‐performance liquid chromatography methods for simultaneous determination of valsartan and atenolol in dosage forms. To find the appropriate high‐performance liquid chromatography conditions for the separation of the examined drugs, various columns, isocratic mobile phase systems were tried, and successful attempts were performed. The used columns proved to be indispensably applicable and gave a shorter analysis time and peak symmetries. This reduction in total run time leads to low solvent consumption and makes all methods more economical. The linearity, accuracy, and precision remained within the acceptable limits. Therefore, all developed methods are suitable for the routine quality control analysis of any pharmaceutical preparation containing the two tested drugs with the proposed chromatographic methods advantages for checking quality during stability studies of their pharmaceutical preparations.
Peer‐to‐peer accommodation: A meta‐analysis of factors affecting customer satisfaction and loyalty
Authors: Shin Hhye Won , Fan Alei , Lehto Xinran 
Published: November 2020

AbstractThe current research synthesizes a decade of peer‐to‐peer accommodation studies published in the hospitality and tourism field, and provides a meta‐analytic review of this topic since its emergence. Following the push versus pull motivation framework, this research investigates how the major factors affect customers' satisfaction and their loyalty in the P2P accommodation setting. Utilizing the Comprehensive Meta‐Analysis Program (CMA), a quantitative meta‐analysis of twenty‐four articles published in the hospitality and tourism journals was conducted to determine the effect sizes of the relationships between the push and pull factors, customer satisfaction and loyalty in the peer‐to‐peer context. The results show that all four push factors have strong positive relationships with satisfaction, whereas the seven pull factors' effect sizes on satisfaction vary. Regarding the relationships with loyalty, both push and pull factors show medium to large effect sizes. In addition, the positive impact of customers' satisfaction on their loyalty in the peer‐to‐peer accommodation context is confirmed. This is the first meta‐analysis effort to provide a collective insight regarding the major factors affecting customer satisfaction and loyalty toward peer‐to‐peer accommodations. It offers a new perspective of “push and pull factors” for future research. Moreover, this research provides guidelines to the operators and marketers about what the most important factors are for customers in using and selecting peer‐to‐peer accommodations.
Corrosion resistance of a cast steel overpack for high‐level radioactive waste disposal in Japan
Authors: Ogawa Yusuke , Suzuki Satoru , Taniguchi Naoki , Kawasaki Manabu , Suzuki Hiroyuki , Takahashi Rieko 
Published: November 2020

AbstractThe corrosion rate and stress corrosion cracking (SCC) susceptibility of a cast steel are studied for its application to metal containers (namely overpacks) for geological disposal of high‐level radioactive waste. Specimens for corrosion tests are cut from a prototype overpack manufactured by full‐scale casting. Casting defects are widely distributed in the prototype overpack; however, the flat‐bottom hole equivalent diameters for all defects detected by an ultrasonic test are 3.6 mm or less, which is relatively small. Forged steels and rolled steels are also tested for comparison of their corrosion properties with the cast steel. The corrosion rates are obtained by immersion tests in bentonite saturated with synthetic seawater under anaerobic conditions at 80°C for up to 1 year. The corrosion rate for the cast steel calculated by the weight loss during the experiments is close to that for the forged steels and rolled steels. The SCC susceptibility is examined using slow strain rate tests in a 1.5‐mol L−1 carbonate–bicarbonate solution, in which the occurrence of high‐pH SCC is often reported for carbon steels. The SCC susceptibility increased with the increase in the carbon content of the products; however, there are no clear differences between casting and forging.
Assessment of cathodic protection effect on long‐distance gas transportation pipelines based on buried steel specimens
Authors: He Guoxi , Peng Hao , Liao Kexi , Wang Minan , Zhao Shuai , Leng Jihui 
Published: November 2020

AbstractDifferent severe corrosions are found at the damaged point of anticorrosive coating on natural gas pipelines, even though the cathodic protection (CP) potential is between −0.85 and −1.15 V. Therefore, there are totally 168 buried steel specimens (BSSs) and 28 soil samples at 28 buried points that are taken out in situ and then analyzed in the lab to assess the CP effectiveness. First, the CP status is simulated by BSSs at the damaged points, and the corrosion products on BSSs are analyzed microscopically. Second, the corrosion rates of the testing BSSs are calculated by the weight‐loss method to perform the quantitative assessment. Third, the specific reasons for external corrosion are explored via analyzing the CP potential attenuation tendency and the corrosiveness of soil. The corrosion growth trend is also investigated by comparing the test results among three test cycles within 8 years. Finally, the control measures for external corrosion of pipelines are put forward. The study is beneficial to evaluate the CP system and determine the causes of external corrosion of pipelines, thereby formulating corresponding protective measures.
What you touch, touches you: The influence of haptic attributes on consumer product impressions
Authors: Ranaweera Achini T. , Martin Brett A. S. , Jin Hyun Seung 
Published: November 2020

AbstractThe present research builds upon the touch literature to show that the salience of haptic product attributes related to product surface texture (smooth, rough) and weight (light weight, heavy weight) influence consumer product impressions. We propose that haptic cue congruity across texture and weight drive consumer product impressions depending on a consumer's need for touch (NFT). We show that high autotelic‐NFT consumers who touch for sensory pleasure enjoyed the incongruity between smooth texture and heavy weight haptic cues, and consequently showed favorable evaluations towards exciting brands. In contrast, low autotelic‐NFT consumers prefer the anticipated match between smooth texture and light weight haptic cues, which conformed to their expectation about the nature of a sophisticated brand personality. Further, we show how the interactive effect of haptic attributes and a consumer's autotelic‐NFT on willingness to purchase is mediated by product personality. Implications for theory and practice are discussed.
A second order convergent difference scheme for the initial‐boundary value problem of Korteweg–de Vires equation
Authors: Wang Xuping , Sun Zhi‐zhong 
Published: November 2020

AbstractIn this article, we present a two‐level implicit difference scheme for Korteweg–de Vires equation with the initial and boundary conditions by the method of order reduction. The truncation error of the difference scheme is analyzed in detail. In the practical computation, the introduced intermediate variable is decoupled in order to reduce the computational cost. It is proved that the difference scheme is solvable by the Browder theorem. The conservation, boundedness, and the unconditional convergence of the numerical solution are also analyzed at length. The convergence order is two both in space and in time in L2‐norm. The numerical solution is proved to be unique under the optimal step ratio condition. Numerical examples demonstrate that the theoretical analysis is correct.
Influence of Weight Loss on Obesity‐Associated Complications After Metabolic and Bariatric Surgery in Adolescents
Authors: Derderian S. Christopher , Patten Luke , Kaizer Alexander M. , Moore Jaime M. , Ogle Sarah , Jenkins Todd M. , Michalsky Marc P. , Mitchell James E. , Bjornstad Petter , Dixon John B. , Inge Thomas H. 
Published: November 2020

ObjectiveFollowing metabolic and bariatric surgery (MBS), most adolescents experience weight loss and improvement of many obesity‐associated complications (OACs). The relationship between weight loss and remission of OACs after MBS in adolescents has not been well described.MethodsThe Teen Longitudinal Assessment of Bariatric Surgery (Teen‐LABS) is a multi‐institutional prospective observational study of adolescents who underwent MBS between 2007 and 2012. Lower‐weight‐loss responders (LWLRs) were defined as having <20% total body weight loss (TBWL) and higher‐weight‐loss responders (HWLRs) were defined as having ≥20% TBWL at 5 years after MBS. The prevalence of OACs was compared at baseline and 5 years after MBS.ResultsBoth LWLRs (n = 114) and HWLRs (n = 78) lost significant weight within the first year following MBS; however, the TBWL at 5 years for the LWLRs was 8.6% ± 9.5% compared with 33.8% ± 9.2% for the HWLRs. Those in the HWLR group were more likely to experience durable remission of composite dyslipidemia at 5 years, whereas there were no differences between groups in remission rates of all other OACs.ConclusionsGreater weight loss after MBS in adolescents was associated with greater remission of composite dyslipidemia; however, remission of other OACs was not dependent on major sustained weight loss.
Hydrophobic nanocomposites of PBAT with Cl‐fn‐POSS nanofiller as compostable food packaging films
Authors: Balaji Sadhasivam , Venkatesan Raja , Mugeeth Loganathan , Dhamodharan Raghavachari 
Published: November 2020

AbstractAntibacterial nanocomposite films of poly(butylene adipate‐co‐terephthalate) (PBAT) incorporated with different weight percentage of octakis(3‐chloropropyl)octasilsesquioxane (chloropropyl functionalized POSS [Cl‐fn‐POSS]) nanofiller were prepared. The mechanical, thermal, morphological, barrier, and antimicrobial properties were examined. The mechanical properties of the nanocomposite films were enhanced by the addition of Cl‐fn‐POSS nanofiller. An optimum filler loading of 3 wt% is identified to be best suited for maximum enhancement in tensile strength (24 MPa for 3 wt% filled PBAT vs 11 MPa for neat PBAT) while a 1 wt% filler loading was adequate to double the tensile strength. The barrier properties (WVTR and oxygen transmission rate) of PBAT was improved by the presence of Cl‐fn‐POSS. A volume of 3 wt% filler loading results in 50% reduction of water permeation and 10% reduction in oxygen transmission. The thermogravimetric analyses of the nanocomposites indicated that the filler enabled the enhancement of thermal stability of PBAT. The nanocomposite films revealed antimicrobial activity with this activity increasing with increasing filler content. PBAT is compostable under suitable conditions and with a low weight percentage of filler that is largely made of silicon dioxide these nanocomposite films can find application as biodegradable food packaging material given their flexibility.
A quest for meaning: A qualitative exploration among children with advanced cancer and their parents
Authors: Schaefer Megan R. , Kenney Ansley E. , Himelhoch Alexandra C. , Howard Sharp Katianne M. , Humphrey Lisa , Olshefski Randal , Young‐Saleme Tammi , Gerhardt Cynthia A. 
Published: November 2020

AbstractObjectiveMeaning‐making may assist individuals in adaptation to stressful life events, particularly bereavement. However, few studies have examined meaning‐making among pediatric populations with advanced illness to understand how this process unfolds before the child's death. This study explores meaning‐making pre‐bereavement among children with advanced cancer and their parents.MethodsAs part of a larger study examining shared decision‐making near the end of life, 24 children with advanced cancer and/or high‐risk cancer, 26 mothers, and 11 fathers participated in individual, semi‐structured interviews. Analyses focused on questions regarding meaning‐making. Four coders analyzed the data via directed content analysis.ResultsThree major meaning‐making themes emerged: (1) sense‐making (i.e., unknown, no sense/meaning, religious/spiritual explanations, scientific explanations), (2) benefit‐finding, and (3) purpose/legacy. Some stated they were unable to make sense of the diagnosis, because there was no reason, they were not there yet, or they were dealing with the situation and moving forward. Others reported finding meaning through spiritual and scientific explanations. Many identified benefits related to the child's illness, such as personal growth and stronger relationships. Some parents expressed their purpose in life was to live for their children, while others shared their child's legacy as a way to find meaning.ConclusionsOur findings highlight the struggle children and parents often face when attempting to make sense of the child's advanced or high‐risk illness. Clinicians might consider if meaning‐centered interventions designed for use in adults at the end of life and bereaved parents may be helpful for children with advanced or high‐risk cancer and their parents.