bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protein interaction network of the inherited central nervous system diseases reveals new gene candidates for molecularly unclassified myelin disorders
Authors: Paris Luca , Como Gianluca , Vecchia Ilaria , Pisani Francesco , Ferrara Giovanni 
Published: October 2020

Abstract
Mutations in numerous genes cause the inherited disorders of the white matter in the central nervous system. Interestingly, all these mutations ultimately affect myelin, even though the corresponding proteins are involved in dissimilar functions. To address this system-level issue, we assembled the myelin disease network (MDN), in which each node represents a protein (either the mutated protein or one of its interactors), while each edge linking two nodes represents the physical interaction between the two proteins. Compared with control random networks, the MDN contains more pairs of disease proteins, whose members are linked either directly or via one intermediate protein. Then, we surmised that the interactions might not only cluster proteins into functionally homogenous and distinct modules but also link the modules together. This way, even gene mutations arising in functionally distinct modules might propagate their effects to the other modules, thus accounting for a similar pathological outcome. We found, however, that concerning the function the modules are neither homogeneous nor distinct, mostly because many proteins participate in more than one biological process. Rather, our analysis defines a region of the interactome, where different processes intersect. Finally, we propose that many non-disease proteins in the network might be candidates for molecularly unclassified myelin disorders.
Two ticking time bombs: giant coronary artery aneurysm and abdominal aortic aneurysm in the setting of urgent vascular surgery—a case report
Authors: Schukraft Sara , Carrel Thierry , Togni Mario , Attinger-Toller Adrian 
Published: October 2020

AbstractBackgroundGiant coronary artery aneurysms (CAAs) are rare and treatment strategies various, especially in the setting of a concomitant abdominal aortic aneurysm (AAA) which needs urgent repair.Case summaryA 78-year-old Caucasian male was admitted for evaluation of a rapidly expanding AAA. In addition, computed tomography angiography revealed a 5 x 4 cm giant aneurysm of the right coronary artery. After interdisciplinary discussion, the patient underwent aorto-bi-iliac bypass grafting first. In a second step, CAA was successfully excluded and coronary artery bypass grafting of the right coronary artery was performed.DiscussionTreatment strategy of CAA and timing of non-cardiac surgery is challenging. In order to minimize the overall risk of rupture interdisciplinary discussion is crucial. In our case, aorto-bi-iliac bypass grafting was safely performed, and the patient underwent successful CAA excision in a second step.
Association between physical performance and cognitive function in older adults across multiple studies: A pooled analysis study
Authors: Handing Elizabeth P , Leng Xiaoyan Iris , Kritchevsky Stephen B , Craft Suzanne 
Published: October 2020

Abstract

Background and Objectives
While several studies have examined the association between cognitive and physical function, the consistency of these associations across functional contexts is unclear. The consistency of association between cognitive and physical function performance was examined at baseline across 17 clinical studies with diverse and heterogeneous conditions such as overweight/obese, sedentary, at risk for a mobility disability, osteoarthritis, low vitamin D, or had signs of cognitive impairment.

Research Design and Methods
Data are from 1,388 adults 50 years and older who completed a cognitive and physical function assessment as part of a research study at the Wake Forest Alzheimer’s Disease Research Center or the Wake Forest Older Americans Independence Center. Linear regression models were used to relate cognitive measures [Mini Mental Status Exam (MMSE), Montreal Cognitive Assessment (MoCA), and the Digit Symbol Substitution Task (DSST)], and physical measures [the Short Physical Performance Battery (SPPB) and hand grip strength] for the whole sample and treat each study as a fixed effect. All models controlled for age, sex, race, and body mass index (BMI).

Results
Overall, there was a significant association between higher scores on the MMSE (per standard deviation) and better physical function performance (SPPB score b= 0.24, p &lt;0.001) and its components (gait speed, chair rise, and standing balance; p’s &lt;0.05). Higher scores on the MoCA produced similar results (SPPB score b= 0.31, p= &lt;0.001) and higher scores on the DSST were also significantly associated with a better SPPB score (b= 0.75, p &lt;0.001). The relationship between DSST and physical function performance demonstrated a stronger magnitude of association compared to the MMSE or MoCA.

Discussion and Implications
Older adults with heterogenous health conditions showed a consistent pattern between better cognitive function and better physical function performance with the strongest association among DSST scores.
The 2020 Historical Research lecture
Authors: Vinen Richard , Langhamer Claire , Siena Kevin 
Published: October 2020

Abstract
The 2020 Historical Research lecture, ‘Writing histories of 2020’, asked how future historians might study and understand the global coronavirus pandemic. The lecture brought together historians with three distinctive perspectives: contemporary history and writing of the very recent past, histories of record keeping and current archive creation, and the history of contagious disease and its human consequences. The three speakers, Richard Vinen, Claire Langhamer and Kevin Siena, provided early responses on future histories of 2020 and how we might best prepare the ground for these studies. This article provides written versions of these commentaries. Common to each of the contributions, and subsequent discussion, is the ongoing challenge and responsibility of thinking historically at a time when history is clearly ‘in the making’.
The role of political leaders in mitigating the risk of mass atrocities: an analysis of Khama, Kaunda and Nyerere
Authors: McLoughlin Stephen 
Published: October 2020

Abstract
This article examines the impact that three political leaders—Seretse Khama, Kenneth Kaunda and Julius Nyerere—had on navigating the long-term risk associated with mass atrocities. While the scholarship on comparative genocide studies has acknowledged the crucial dimension of leadership in the perpetration of such violence, very little is known about the preventive influence of leaders in cases where risk is present. This influence works both ways: the ideas, decisions and policies of political leaders are often the most instrumental factor in effective processes of risk mitigation. Yet to date, there has been no systematic study of the role of leadership in managing and ameliorating risk associated with mass atrocities. Indeed, the more general question of why mass atrocities do not occur is also largely neglected. I argue that these leaders were cognisant of the disruptive potential of tribal, ethnic and religious division; they advocated for inclusive national identities and developed policies that fostered social cohesion; and were effective in creating social and political environments that had an inhibitory effect on structural risk factors associated with atrocity crimes.
Development and Validation of an Inflammatory Bowel Disease Severity Index Using US Administrative Claims Data: A Retrospective Cohort Study
Authors: Chen Grace , Lissoos Trevor , Dieyi Christopher , Null Kyle D 
Published: October 2020

Abstract

Background
Clinical indices to characterize the severity of inflammatory bowel disease (IBD) are widely used in clinical trials and real-world practice. However, there are few validated instruments for assessing IBD severity in administrative claims-based studies.

Methods
Patients (18–89 years) diagnosed with ulcerative colitis (UC) or Crohn’s disease (CD) and receiving ≥1 prescription claim for IBD therapy were identified using administrative claims data from the Optum Clinformatics, IMS PharMetrics, and Truven MarketScan databases (January 1, 2013–September 30, 2017). Regression modeling identified independent predictors of IBD-related hospitalization (inpatient stay or emergency department visit resulting in hospitalization), which were used to develop IBD severity indices. The index was validated against all-cause hospitalization and total cost and IBD-related hospitalization and total cost.

Results
There were 51,767 patients diagnosed with UC (n = 30,993) or CD (n = 20,774) who were initiated treatment with IBD therapy. Independent predictors of IBD-related hospitalization were Charlson Comorbidity Index score &gt;1, anemia, weight loss, intravenous corticosteroid use, prior gastrointestinal-related emergency department visit and hospitalization, and unspecified disease location or more extensive disease. Female sex, renal comorbidities, intestinal fistula, and stricture were additional risk factors for patients with CD, whereas age &lt;40 years was a UC-specific risk factor. Median IBD severity scores were 8 and 13 for UC and CD, respectively, from possible total scores of 51 and 37. Inflammatory bowel disease severity score correlated with significantly higher all-cause hospitalization and cost, all-cause total cost, IBD-related hospitalization cost, and total cost.

Conclusions
These validated UC and CD severity indices can be used to predict IBD-related outcomes using administrative claims databases.
Climate warming and the loss of sea ice: the impact of sea-ice variability on the southeastern Bering Sea pelagic ecosystem
Authors: Hunt George L , Yasumiishi Ellen M , Eisner Lisa B , Stabeno Phyllis J , Decker Mary Beth 
Published: October 2020

AbstractWe investigated relationships among three metrics of sea-ice cover in eight regions of the eastern Bering Sea and the abundance of Calanus copepods, jellyfish medusae, and year-class strength of walleye pollock (Gadus chalcogrammus). In summer, Calanus spp. were more abundant over the middle shelf when sea ice lingered late into spring, and, to a lesser extent, when February sea-ice cover was heavy. Between 1982 and 1999, there were no significant (p ≤ 0.05) relationships between the amount or timing of sea-ice cover and pollock recruitment. However, between 2000 and 2015, pollock year-class strength was positively correlated with sea ice in the outer and middle shelves, with 17 of 24 regressions significant. Pollock year-class strength was best predicted by days with sea-ice cover after February. Pollock recruitment was positively influenced by copepod numbers, particularly in the middle shelf, with r2 values from 0.36 to 0.47. We hypothesize that the Calanus spp. present in the southeastern Bering Sea are primarily Calanus glacialis that have been advected south in association with sea ice. None of our sea-ice metrics explained the variance in jellyfish biomass. Jellyfish biomass in our study area in the pollock age-0 year was not correlated with pollock recruitment 3 years later.
Prevalence of Germline Pathogenic and Likely Pathogenic Variants in Patients With Second Breast Cancers
Authors: Yao K Katharine A , Clifford Jacob , Li Shuwei , LaDuca Holly , Hulick Peter , Gutierrez Stephanie , Black Mary Helen 
Published: October 2020

Abstract

Background
Few studies have examined gene-specific associations with contralateral and/or second breast cancer (SBC).

Methods
The frequency of pathogenic and likely pathogenic (P/LP) variants in clinically actionable genes (BRCA1, BRCA2, PTEN, TP53, CHEK2, CDH1, ATM, PALB2, NBN, and NF1) was compared between women with a primary breast cancer (PBC) and SBC who underwent multigene panel testing at a single diagnostic testing laboratory. Race- and ethnicity-specific logistic regression burden tests adjusted for age at diagnosis of first breast cancer, histology, presence of first- or second-degree relatives with breast cancer, and prior testing for BRCA1/2 genes were used to test for associations with SBC. All statistical tests were 2-sided.

Results
The study was comprised of 75 550 women with PBC and 7728 with SBC. Median time between breast cancers for SBC was 11 (interquartile range = 6–17) years. Restricting to women tested for all actionable genes (n = 60 310), there were 4231 (7.8%) carriers of P/LP variants in actionable genes among the controls (PBC) compared with 652 (11.1%) women with SBC (P&lt; .001). Among Caucasians, exclusive of Ashkenazi Jewish women, those carrying a P/LP variant in a clinically actionable gene were 1.44 (95% confidence interval [CI] = 1.30 to 1.60) times as likely to have SBC than noncarriers, after accounting for potential confounders. Among African American and Hispanic women, a P/LP variant in a clinically actionable gene was 1.88 (95% CI = 1.36 to 2.56) and 1.66 (9% CI = 1.02 to 2.58) times as likely to be associated with SBC, respectively (P &lt; .001 and P = .03).

Conclusion
Women with P/LP variants in breast cancer predisposition genes are more likely to have SBC than noncarriers. Prospective studies are needed confirm these findings.
The Temporal and Geographic Reach of International Humanitarian Law
Authors: Crawford Emily 
Published: October 2020

Abstract
This chapter discusses the geographical and temporal scope of international humanitarian law (IHL). Knowing where and when the provisions of IHL start and cease to apply is vital to ensuring that the rules are respected, and to identifying where other rules of international and domestic law are pertinent or more relevant. As a general rule, IHL applies from the commencement of hostilities, whether such hostilities are international or non-international in character. In international armed conflicts (IACs), situations of belligerent occupation also trigger the applicability of IHL, even if there are no active hostilities. However, there are different thresholds applicable in international and non-international armed conflicts (NIACs). As a general rule, in both IACs and NIACs, IHL will cease to apply when there is a ‘general close of military operations’. Meanwhile, the geographical or spatial scope of IHL depends on what kind of armed conflict is taking place, with different issues arising for both NIACs and IAC.
The effects of subgrid models on the properties of giant molecular clouds in galaxy formation simulations
Authors: Li Hui , Vogelsberger Mark , Marinacci Federico , Sales Laura V , Torrey Paul 
Published: October 2020

ABSTRACT
Recent cosmological hydrodynamical simulations are able to reproduce numerous statistical properties of galaxies that are consistent with observational data. Yet, the adopted subgrid models strongly affect the simulation outcomes, limiting the predictive power of these simulations. In this work, we perform a suite of isolated galactic disc simulations under the SMUGGLE framework and investigate how different subgrid models affect the properties of giant molecular clouds (GMCs). We employ astrodendro, a hierarchical clump-finding algorithm, to identify GMCs in the simulations. We find that different choices of subgrid star formation efficiency, ϵff, and stellar feedback channels, yield dramatically different mass and spatial distributions for the GMC populations. Without feedback, the mass function of GMCs has a shallower power-law slope and extends to higher mass ranges compared to runs with feedback. Moreover, higher ϵff results in faster molecular gas consumption and steeper mass function slopes. Feedback also suppresses power in the two-point correlation function (TPCF) of the spatial distribution of GMCs. Specifically, radiative feedback strongly reduces the TPCF on scales below 0.2 kpc, while supernova feedback reduces power on scales above 0.2 kpc. Finally, runs with higher ϵff exhibit a higher TPCF than runs with lower ϵff, because the dense gas is depleted more efficiently, thereby facilitating the formation of well-structured supernova bubbles. We argue that comparing simulated and observed GMC populations can help better constrain subgrid models in the next generation of galaxy formation simulations.
The AGN fuelling/feedback cycle in nearby radio galaxies – III. 3D relative orientations of radio jets and CO discs and their interaction
Authors: Ruffa Ilaria , Laing Robert A , Prandoni Isabella , Paladino Rosita , Parma Paola , Davis Timothy A , Bureau Martin 
Published: October 2020

ABSTRACT
This is the third paper of a series exploring the multifrequency properties of a sample of eleven nearby low-excitation radio galaxies (LERGs) in the southern sky. We are conducting an extensive study of different galaxy components (stars, dust, warm and cold gas, radio jets) with the aim of better understanding the AGN fuelling/feedback cycle in LERGs. Here, we present new, deep, sub-kpc resolution Karl G. Jansky Very Large Array (JVLA) data for five sample sources at 10 GHz. Coupling these data with previously acquired Atacama Large Millimetre/submillimetre Array (ALMA) CO(2–1) observations and measurements of comparable quality from the literature, we carry out for the first time a full 3D analysis of the relative orientations of jet and disc rotation axes in six FR I LERGs. This analysis shows (albeit with significant uncertainties) that the relative orientation angles span a wide range (≈30○–60○). There is no case where both axes are accurately aligned and there is a marginally significant tendency for jets to avoid the disc plane. Our study also provides further evidence for the presence of a jet-CO disc interaction (already inferred from other observational indicators) in at least one source, NGC 3100. In this case, the limited extent of the radio jets, along with distortions in both the molecular gas and the jet components, suggest that the jets are young, interacting with the surrounding matter and rapidly decelerating.
Redshifted 21-cm bispectrum – I. Impact of the redshift space distortions on the signal from the Epoch of Reionization
Authors: Majumdar Suman , Kamran Mohd , Pritchard Jonathan R , Mondal Rajesh , Mazumdar Arindam , Bharadwaj Somnath , Mellema Garrelt 
Published: October 2020

ABSTRACT
The bispectrum can quantify the non-Gussianity present in the redshifted 21-cm signal produced by the neutral hydrogen ($\rm {H \small {I}}$) during the Epoch of Reionization (EoR). Motivated by this, we perform a comprehensive study of the EoR 21-cm bispectrum using simulated signals. Given a model of reionization, we demonstrate the behaviour of the bispectrum for all unique triangles in k space. For ease of identification of the unique triangles we parametrize the k-triangle space with two parameters, namely the ratio of the two arms of the triangle (n = k2/k1) and the cosine of the angle between them (cos θ). Furthermore, for the first time we quantify the impact of the redshift space distortions (RSD) on the spherically averaged EoR 21-cm bispectrum in the entire unique triangle space. We find that the real space signal bispectra for small and intermediate k1-triangles ($k_1 \le 0.6 \, \, {\rm Mpc}^{-1}$) is negative in most of the unique triangle space. It takes a positive sign for squeezed, stretched, and linear k1-triangles, specifically for large k1 values ($k_1 \ge 0.6 \, \, {\rm Mpc}^{-1}$). The RSD affects both the sign and magnitude of the bispectra significantly. It changes (increases/decreases) the magnitude of the bispectra by $50\!-\!100{{\ \rm per\ cent}}$ without changing its sign (mostly) during the entire period of the EoR for small and intermediate k1-triangles. For larger k1-triangles, RSD affects the magnitude by $100\!-\!200{{\ \rm per\ cent}}$ and also flips the sign from negative to positive. We conclude that it is important to take into account the impact of RSD for a correct interpretation of the EoR 21-cm bispectra.
A principal component analysis of polycyclic aromatic hydrocarbon emission in NGC 2023
Authors: Sidhu Ameek , Peeters Els , Cami Jan , Knight Collin 
Published: October 2020

ABSTRACT
We use the measured fluxes of polycyclic aromatic hydrocarbon (PAH) emission features at 6.2, 7.7, 8.6, 11.0, and 11.2 μm in the reflection nebula NGC 2023 to carry out a principal component analysis (PCA) as a means to study previously reported variations in the PAH emission. We find that almost all of the variations (99 per cent) can be explained with just two parameters – the first two principal components (PCs). We explore the characteristics of these PCs and show that the first PC (PC1), which is the primary driver of the variation, represents the amount of emission of a mixture of PAHs with ionized species dominating over neutral species. The second PC (PC2) traces variations in the ionization state of the PAHs across the nebula. Correlations of the PCs with various PAH ratios show that the 6.2 and 7.7 μm bands behave differently than the 8.6 and 11.0 μm bands, thereby forming two distinct groups of ionized bands. We compare the spatial distribution of the PCs to the physical conditions, in particular to the strength of the radiation field, G0, and the G0/nH ratio and find that the variations in PC2, i.e. the ionization state of PAHs are strongly affected by G0 whereas the amount of PAH emission (as traced by PC1) does not depend on G0.
Dark supernova remnant
Authors: Sofue Yoshiaki 
Published: October 2020

Abstract
An almost perfect round hole of CO-line emission with a diameter of 3.7 pc was found in a molecular cloud (MC) centered on G35.75−0.25 (l = 35${{^{\circ}_{.}}}$75, b = −0${{^{\circ}_{.}}}$25) at radial velocity of 28 km s−1. The hole is quiet in radio continuum emission, unlike the usual supernova remnants (SNR), and the molecular edge is only weakly visible in 8 and 24 μm dust emissions. The hole may be either a fully evolved molecular bubble around a young stellar object (YSO), or a relic of a radio-quiet SNR that has already stopped expansion after rapid evolution in the dense MC as a buried SNR. Because G35.75 exhibits quite different properties from YSO-driven bubbles of the same size, we prefer the latter interpretation. The existence of such a “dark” SNR would affect the estimation of the supernova rate, and therefore the star formation history, in the Galaxy.