bluuebunny/crossref_metadata_2025_split huggingface dataset:
APPLICATION OF ELISA AND HPLC-MS/MS METHODS IN CLINICAL TRIALS OF VETERINARY DRUGS FOR THE DETERMINATON OF IVERMECTIN CONTENT
Authors: Yanovych D. , Zasadna Z. , Rydchuk M. , Plotytsia S. , Kislova S. , Pazderska O. , Korol N. , Trach Y. 
Published: December 2024

The article presents the results of the development and validation of screening method and chromatographic mass spectrometric method for the determining of ivermectin residual amounts in muscles and parenchymal tissues of pigs and calves, as well as in blood plasma, for clinical trials (for withdrawal period establishing and bioequivalence study of drugs based on ivermectin).
EuroProxima Ivermectin test kits (Netherlands) were used to determine ivermectin residues in animal tissues. When carrying out the validation at the levels of ½ MRL, which is 15 and 30 μg/kg for muscle and parenchymal tissues, the LOD for the analyte was established at the levels of 2.7 and 4.1 μg/kg, respectively. To establish the percent of analyte’s recovery from the spiked samples, selected blank samples and samples, spiked with ivermectin solution at ½ MRL and MRL levels, were prepared and analyzed according to the technique provided by the test kit manufacturer. The percentage of analyte’s recovery for muscle tissues spiked at the level of 15.0, 30.0, 100.0 μg/kg was: 100.2, 100.4, 99.9, respectively. For liver tissues, spiked at the level of 50.0, 100.0, 500.0 μg/kg, it was 100.0, 99.95, 99.5, respectively.
To establish the bioequivalence of veterinary drugs based on ivermectin, we have developed and validated high-performance liquid chromatography with tandem mass spectrometric detection (HPLC-MS/MS) method. The suggested method of sample preparation includes the liquid-liquid extraction of the analyte with ethyl acetate from an acidic medium and concentration by drying. Analysis of the prepared samples was performed by HPLC-MS/MS (analyte’s retention time 2.64 min, mass scanning parameters: precursor ion 892.8 m/z, product ions 307.2 and 569.4 m/z). Various key parameters were used to validate the chromatographic technique: limit of detection, limit of quantification, working and linear concentration ranges, accuracy, and precision. The results of the performed validation are presented in the article in tables and chromatograms, and conclusions about the fitness-for-purpose of the method are also made.
"Educa-Ação" física: uma abordagem curricular na formação de profissionais
Authors: Peres Luís Sérgio 
Published: December 2024

Este estudo teve como objetivo refletir sobre a formação e estruturação dos currículos dos cursos de Educação Física no Brasil, destacando a necessidade de uma abordagem que vá além da técnica e do esporte como fins exclusivos, considerando aspectos sociais, culturais e humanos. O trabalho aborda a crise na educação brasileira, caracterizada por desafios como a desvalorização dos professores, a baixa qualidade do ensino e a fragmentação do currículo. Destaca-se a necessidade de repensar a docência, aproximando-a de uma perspectiva crítica e transformadora. Discute-se a importância de um currículo que integre teoria e prática, além de enfatizar o desenvolvimento de competências investigativas, críticas e sociais nos futuros profissionais de Educação Física. O estudo também alerta para os problemas de uma formação tecnicista e propõe a inclusão de práticas pedagógicas comprometidas com a realidade social e cultural. A Educação Física no Brasil necessita de uma reformulação curricular que contemple a formação integral dos profissionais, promovendo uma educação voltada para a transformação social, o bem-estar e a qualidade de vida. O texto reforça a urgência de mudanças estruturais que alinhem o curso às demandas contemporâneas e incentivem a reflexão sobre a prática docente.
Análise das ações de vigilância epidemiológica da COVID-19 no Brasil: um estudo de revisão
Authors: Nayara Paiva Dantas Marianny , Araújo Rocha Mayara , Porto Alves Jairo , Simone Galvão Pinto Erika , Lima de Souza Nilba , Assis Neves Dantas Rodrigo , Maria de Medeiros Soraya , Sami Albuquerque de Oliveira Jonas 
Published: December 2024

Introdução: Os serviços de Vigilância Epidemiológica foram fundamentais no enfrentamento da COVID-19, entretanto, diversos fatores estiveram como entraves na atuação deste seguimento da saúde pública no Brasil. Deste modo, este estudo busca evidenciar as lições aprendidas. Objetivo: analisar ações dos serviços de vigilância epidemiológica durante a pandemia da COVID-19 no Brasil.
Objetivo: Analisar ações dos serviços vigilância epidemiológica para o enfrentamento da pandemia da COVID-19 no Brasil, representadas pelo uso das ferramentas SWOT e 5W2H.
Método: Revisão integrativa realizada em cinco etapas, com coleta de dados em dezembro de 2021, mediante a busca de publicações elegíveis em bases de dados. Os dados foram tabulados e analisados de forma descritiva, através das ferramentas (SW2H) What (o que deve ser feito?), Why (por que deve ser feito?), Where (onde deve ser feito?), When (quando deve ser feito?), Who (por quem deve ser feito?), How (como deve ser feito?), How much (quanto irá custar?) e a matriz (SWOT) Strengths (Forças), Weaknesses (Fraquezas), Opportunities (Oportunidades) e Threats (Ameaças).
Resultados: As ações descritas nos estudos são provenientes das vigilâncias municipais, estaduais, Ministério da Saúde e núcleo de vigilância epidemiológica de serviços de saúde, os quais, articulados a órgãos da saúde e de outras áreas buscaram o enfrentamento da pandemia e redução de seus efeitos à saúde pública. Houve fragilidades na articulação com as demais vigilâncias em saúde e atenção primária a saúde. Utilizou-se recursos para melhoria de processos e estrutura do Sistema Único de Saúde.
Conclusão: As ações de enfrentamento da pandemia pelas vigilâncias epidemiológicas envolveram diversos setores da sociedade, tiveram impacto individual e coletivo. Fragilidades e ameaças inerentes as entidades envolvidas e à crise sanitária, apresentaram-se como desafios à vigilância epidemiológica, porém, destaca-se sua relevância para a redução do impacto da COVID-19 no cenário brasileiro.
Analisis Perilaku Konsumen terhadap Top Up di Platfrom Digital : Studi Netnografi
Authors: Maulana Affan 
Published: December 2024

Saat ini kemajuan teknologi informasi terus berkembang dalam membantu kehidupan manusia Menurut Kemkominfo, di Indonesia pengguna internet mencapai 82 juta orang dan mencapai peringkat ke-8 dunia. Saat ini secara bertahap konsumen mulai menerima internet dan melakukan transaksi pembelian, dengan semakin meningkatnya penggunaan layanan digital dalam kehidupan sehari-hari, baik untuk kebutuhan transaksi, hiburan maupun layanan lainnya, semakin populer. Konsumen menghadapi berbagai platform yang memberikan kemudahan dan kecepatan saat membayar, namun mereka juga perlu mempertimbangkan aspek keamanan dan transparansi. Fenomena ini menciptakan dinamika baru yang baik untuk diteliti, terutama untuk memahami bagaimana konsumen berinteraksi dengan layanan canggih secara online. Penelitian ini bertujuan untuk menganalisis perilaku konsumen terkait aktivitas top-up di platform digital melalui pendekatan netnografi. Faktor-faktor utama yang memengaruhi keputusan konsumen meliputi kemudahan akses, keamanan transaksi, promosi menarik, dan ulasan positif dari komunitas online. Dalam komunitas digital, konsumen berbagi pengalaman dan mencari solusi atas kendala yang mereka hadapi, seperti kegagalan transaksi, keterbatasan metode pembayaran, serta kekhawatiran terhadap penipuan dan penyalahgunaan data. Penelitian ini menggunakan metode kualitatif dengan analisis data sekunder dari komunitas online terkait. Hasilnya menunjukkan pentingnya platform digital untuk meningkatkan pengalaman pengguna melalui antarmuka yang ramah pengguna, keamanan data, dan strategi promosi yang efektif. Dengan memahami kebutuhan konsumen, penyedia layanan dapat membangun kepercayaan dan loyalitas yang lebih baik dalam ekosistem digital.
Ajaran Nistha-Madya-Utama dalam Beberapa Teks Jawa
Authors: Wardhana Christiana Dwi 
Published: December 2024

Pada zaman Surakarta Awal banyak kita jumpai karya sastra Jawa hasil gubahan karya sastra-karya sastra dari zaman sebelumnya. Karya sastra-karya sastra zaman Surakarta Awal itu, isinya penuh dengan ajaran moral dan etika (sastra piwulang). Zaman Surakarta Awal tersebut oleh Pigeaud disebut sebagai zaman "renaissance" kesusasteraan Jawa, dan Poerbatjaraka menyebut sebagai zaman "pembangunan" kesusasteraan Jawa. Salah satu piwulang 'ajaran' moral dan etika yang terdapat dalam karya sastra tersebut di atas, ialah ajaran nistha - madya - utama (selanjutnya disingkat NMU). Dalam karya sastra-karya sastra yang akan disebutkan di bawah, ajaran NMU bukan merupan ajaran yang mandiri, dalam arti ada kitab khusus yang membicarakan ajaran tersebut. Posisi ajaran NMU biasanya hanya merupakan salah satu unsur dari sejumlah unsur-unsur ajaran lainnya yang terjalin dalam suatu kitab.Â Akan tetapi dalam kitab-kitab tertentu, posisi ajaran NMU menempati posisi sentral, dalam arti dipakai sebagai wawasan moral dan etika.
Deskripsi Antropologi Medis: Manfaat Binatang dalam Tradisi Pengobatan
Authors: Sudardi Bani 
Published: December 2024

Artikel ini bertujuan mendeskripsikan model pengobatan yang memanfaatkan binatang (animal medicine) yang terdapat dalam tradisi Jawa, khususnya Jawa pedalaman di sekitar Surakarta dan mengkategorikan model-model tersebut ke dalam kerangka teoretis antropologi medis, baik dengan model personalitik maupun model naturalistik. Metode yang digunakan dalam penelitian ini ialah metode penelitian kualitatif dan bersifat deskriptif dengan model analisis interaktif. Penulis menyimpulkan bahwa dalam tradisi pengobatan dengan menggunakan hewan di dalam masyarakat Jawa digunakan berbagai jenis hewan yang terdapat di sekitarnya. Tradisi tersebut kemungkinan sudah berlangsung dari generasi ke generasi. Hal tersebut dapat dibuktikan dengan terangkumnya resep-resep tersebut di dalam kitab primbon yang berasal dari ratusan tahun silam.Â Beberapa tradisi kemungkinan berasal dari luar budaya Jawa yang masuk ke dalam tradsi Jawa seiring dengan pergaulan masyarakata Jawa dengan masyarakat lainnya. Sebagaimisal pengobatan dengan hati unta, kadal Mesir, dan ramuan kobra. Penggunaan hewan dari masa lalu sebagian juga sudah tidak dikenal lagi seiring dengan punahnya hewan tertentu.
Vers la protection du patrimoine postmoderne
Authors: Couturier Bastien 
Published: December 2024

Tandis que le patrimoine moderne, ainsi que les courants architecturaux qui l’ont précédé, bénéficient d’une reconnaissance internationale et de nombreuses mesures de protection patrimoniale par les institutions nationales européennes, l’héritage postmoderne semble être absent des listes de biens nationaux d’intérêt culturel. L’étude menée vise à comparer les édifices postmodernes reconnus et protégés en France, en Italie, en Espagne et au Royaume-Uni, pour comprendre quels freins réglementaires sont susceptibles d’entraver la reconnaissance du patrimoine architectural et la sauvegarde des œuvres postmodernes.
Rhabillez-moi ! Stratégies sur mesure dans la réhabilitation de cinq immeubles de logements postmodernes parisiens
Authors: Correia Julien 
Published: December 2024

L’ouvrage Paris Postmoderne paru en 2023 met en lumière la quantité d’édifices parisiens souvent visibles mais généralement méconnus de cette période des années 1973-1993. En proposant cet inventaire, Jean-Louis Violeau invite à réfléchir au devenir de cet héritage bâti. Quantité d’entre eux sont des immeubles d’habitations qui font aujourd’hui l’objet d’une campagne de réhabilitation visant généralement à résoudre une problématique thermique par une intervention systématisée sur l’enveloppe. L’amélioration des performances thermiques, du confort et des usages consistant en la rénovation des parties communes et des pièces humides peut éventuellement faire partie des cahiers des charges. Les problématiques posées par ce type de programme sont multiples : elles mêlent à la foi le positionnement théorique et technique à des questions de dessin et de la matérialité des façades. Elles interrogent en outre la décision unilatérale de cette seule  mais cependant imposée  intervention sur l’enveloppe en prenant en compte d’autres composantes des édifices (structure, composition du logement, etc.), le plus souvent absentes de la question programmatique posée.Le langage formel varié et le foisonnement de détails tendant parfois à la surcomplexification d’immeubles au demeurant simples et à vocation ordinaire sont aujourd’hui mis en crise par la nécessité d’isoler thermiquement ces édifices, tout en garantissant leur pérennité d’usage et leur caractère. Cet article propose une analyse réflexive sur la pratique de l’agence d’architecture parisienne de Jean-Marin et asssocié.es à partir de cinq cas d’études : l’immeuble d’angle du 31, rue des Malmaisons, celui des 97-105, rue de la Jonquière, l’ensemble du 11, rue Duris, la cour du Liégat et l’ensemble des Hautes-Formes. Au gré des projets, dont les premières étapes de réflexion remontent à 2016, les réponses s’adaptent. Il s’agit alors d’interroger l’acculturation de l’agence à l’architecture postmoderne autant que l’émergence implicite d’une méthodologie de projet.
Foucault et le scandale de l’expertise
Authors: Lamy Jérôme 
Published: December 2024

Michel Foucault s’est intéressé à l’expertise médicale de façon discontinue. Cependant, en rassemblant les fragments d’interprétation laissés dans son œuvre, il est possible de reconstituer une logique historique du déploiement de l’expertise. En prenant appui sur la notion de scandale – cette capacité à heurter les valeurs morales d’une époque – cet article propose de singulariser la philosophie de l’expertise telle que Michel Foucault l’a conçue. Dans l’Histoire de la folie à l’âge classique, l’expertise est décrite dans son congédiement le plus immédiat : la crainte du scandale motive le besoin de la discrétion. Le cours sur Les Anormaux au Collège de France propose d’analyser l’expertise au xixe siècle comme un possible renversement : publicisée, l’expertise médicale se défait de ses appuis épistémologiques pour se muer en rapport moral sur les conduites. Ce faisant, les experts suscitent le scandale en dénonçant les irrégularités d’un comportement que la loi condamne et la société réprouve. Enfin, dans La volonté de savoir, Foucault spécifie cette place scandaleuse de l’expertise en étudiant la façon dont le discours bavard sur le sexe a été conçu comme un moyen de produire des normes éthiques.
Ultraviolet-Induced Fluorescence Dermoscopy, a Novel Diagnostic Technique in Dermatological Practice: A Systematic Review
Authors: Bhat Yasmeen Jabeen , Ul Islam Mohd Shurjeel , Errichetti Enzo 
Published: December 2024

Abstract

Introduction:
Ultraviolet-induced fluorescence dermoscopy (UVF dermoscopy) is a novel diagnostic technique for identifying and diagnosing numerous skin tumors, inflammatory dermatoses, and infectious diseases. The ultraviolet (UV) band has a wavelength ranging from 10 to 400 nm. When intense UV radiation with shorter wavelengths strikes a target chromophore, visible light (VL) with a longer wavelength and lower energy is produced in the skin. This VL is apparent to the naked eye and is referred to as fluorescence.

Aim:
The current review compares ultraviolet fluorescence dermoscopy (UVFD) and polarized dermoscopy (PD) features in various dermatological disorders.

Materials and Methods:
This review was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Metanalyses) guidelines. A comprehensive search of the literature was carried out through the PubMed and Google Scholar electronic databases from inception to 25th December 2023 using the following search terms: “UV dermoscopy” OR “ultraviolet fluorescence dermoscopy” OR “ultraviolet-induced fluorescence dermoscopy” OR “Ultraviolet-induced fluorescent dermoscopy”. Titles, abstracts, and full texts were screened by two independent reviewers to select papers dealing with UVF-dermoscopy.

Results:
A total of 23 relevant articles were included in this systematic review, including a total of 313 patients. Pigmented skin tumors included 209 patients, Fordyce spot mimickers (13), scabies (57), biopsy site (20), psoriasis (3), corynebacterium infections (2), fungal infections (4), vitiligo (3), acne folliculitis (1) and glomus tumors (1). Levels of evidence (LoE) was 3 and 4 in only two included studies; the rest had a LoE of 5.

Discussion:
UVF dermoscopy is a new diagnostic and prognostic tool for neoplastic and non-neoplastic dermatological conditions. This is the first systematic review of its sort that compares and categorizes dermoscopic findings in UVF and polarized light in dermatological practice. As UVFD does not penetrate deeper skin layers, we observed that it is a better way to distinguish features restricted to the skin’s superficial layers in neoplastic diseases. As a result, tumor-free margins and improved surgical outcomes can be achieved. More favorable outcomes for evaluation and treatment were seen with non-neoplastic conditions. Limitations included a lack of studies with a high level of evidence, control groups, and larger sample sizes.

Conclusion:
We concluded that UVFD will improve clinical diagnosis, disease management, and outcomes. More clinical trials with larger sample sizes are recommended to better understand this novel and intriguing new diagnostic tool.
Lipid Profile Scores Predict Severity of Pemphigus: A Cross-Sectional Study
Authors: Fallah Maryam , Najafi Anahita , Ranjbar Mahsa , Balighi Kamran , Daneshpazhooh Maryam , Ebrahimpour-Koujan Soraiya 
Published: December 2024

Abstract

Background:
There is little evidence about the relationship between lipid indices and the severity of pemphigus vulgaris (PV) disease. In this cross-sectional study, we try to find out the exact relationship between three dietary lipid indices (PUFA/SFA ratio and ω-6/ω-3 index) and the severity of PV disease.

Methods:
In this hospital-based cross-sectional study, a total of 138 pemphigus vulgaris cases were studied, of which 108 had PDAI ≤15, and 30 had PDAI>15. Dietary intakes were measured a valid 168-item FFQ. To calculate the lipid indices, the data received from diet were used.

Results:
After adjusting for potential confounders, people with the highest ω-6/ω-3 index had 32% lowest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 0.68; 95% CI: 0.24–1.93, P
trend = 0.47). Moreover, people with the highest PUFA/SFA index had 9% highest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 1.09; 95% CI: 0.34–3.51, P
trend = 0.88).

Conclusion:
The evidence of our study shows that the relation between PUFA/SFA ratio and ω-6/ω-3 index is not significant. However, case–control studies are needed to confirm these findings.
Coexistence of hemophagocytic lymphohistiocytosis and Kikuchi disease – Are they continuum of single entity or two different entities?
Authors: Kumar K. J. Sampath , Raghuram Y. Saadvik , Bali N. Kavitha 
Published: December 2024

ABSTRACT

Background:
Kikuchi-Fujimoto disease (KFD) and hemophagocytic lymphohistiocytosis (HLH) are both rare conditions that affect the lymphatic system. KFD is characterized by necrosis and karyorrhectic debris, while HLH is characterized by hemophagocytosis, a process in which immune cells called histiocytes consume red blood cells and platelets. Both conditions can present with similar symptoms, but their clinical courses and management differ significantly.

Case Presentation:
A 35-year-old South East Indian male presented with high-grade fever, loose motions, and generalized lymphadenopathy. Bone marrow biopsy revealed hemophagocytosis, and cervical lymph node biopsy showed necrotizing lymphadenitis. The patient’s symptoms and laboratory findings met the diagnostic criteria for HLH.

Conclusion:
The patient was treated with dexamethasone (20 mg/m2/day) alone without immunosuppressive therapy, and his general condition improved over a week. The patient was in remission on the last day of follow-up after three months of discharge. This case highlights the importance of distinguishing between KFD and HLH based on clinical presentation and laboratory findings, as their management differs significantly. While KFD is a self-limiting condition, HLH requires aggressive management due to its life-threatening nature.
Pleomorphic rhabdomyosarcoma of uterine corpus with overlapping features of undifferentiated tumour – A rare investigated entity in gynaecologic pathology
Authors: Prachi  , Aiyer Hema Malini , Sharma Gaurav 
Published: December 2024

ABSTRACT
Pleomorphic rhabdomyosarcomas (RMS) of the uterine corpus is a rare malignant tumour of the female genital tract. Pleomorphic RMS of uterine corpus with overlapping features of undifferentiated carcinoma is one of the rarest investigated gynaecological entities. Delving into the depths of this rare malignancy, we share an insight into a 68-year-old female, who presented with a large abdominopelvic mass. Further, the patient underwent a hysterectomy, bilateral salpingo-oophorectomy along with omentectomy, and was diagnosed with pleomorphic RMS with overlapping features of the undifferentiated tumour by histopathology and combined with immunohistochemistry. We navigate through diagnostic intricacies and prognostic considerations and unravel the complexities of PMRSu and its implications for patient care and management.
Analysis of deaths due to gender-based violence: An autopsy-based cross-sectional study from Mumbai
Authors: Pathak HM , Kaur A , Chaudhary N , Paul AS 
Published: December 2024

ABSTRACT

Introduction:
Gender-based violence (GBV), including domestic violence, honor killings, and dowry deaths, represents one of the most extreme forms of violence against women. These deaths are often misclassified as accidents or suicides due to societal biases, leading to underreporting and obscuring the true impact of GBV on women’s mortality.

Aims and Objectives:
This study aimed to evaluate the prevalence of GBV-related deaths, with a focus on cases misreported as accidents or suicides. The objective was to determine the proportion of female deaths attributable to GBV and to highlight the challenges in reporting and investigating these cases.

Materials and Methods:
A retrospective, cross-sectional study was conducted at a medical teaching institution in Mumbai, analyzing 5 years (May 2017–April 2022) of autopsy data involving unnatural female deaths. Autopsy records, police reports, and victim/relative statements were examined to identify potential GBV cases and discrepancies in death classification.

Results:
The study found a significant proportion of female deaths attributed to GBV, primarily within domestic settings. Many cases initially reported as accidents or suicides showed discrepancies in injury patterns and circumstances. The majority of GBV victims were young women aged 15–44 years, with burns being the most common cause of death.

Conclusion:
The study emphasizes the need for improved investigation and classification of unnatural female deaths. Domestic violence emerged as the most common factor in these deaths, with intimate partners being primary perpetrators, with most incidents occurring within the home. It also stresses on enhanced protocols to accurately identify and address GBV-related fatalities.