bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: A castration-resistant terminal prostate cancer patient’s survival prolonged after practicing Falun Gong
Authors: Dong Yu-Hong , Wu Shawn , Corson Ann , Hsu Kai-Hsiung 
Published: October 2019

Background: Most metastatic prostate cancer patients receive androgen deprivation therapy (ADT) as the mainstay of treatment. Unfortunately, patients ultimately progress to castration resistance. Clinical finding and diagnosis: We describe a man in his eighties who developed stage IV, M1b prostate cancer, and multiple (≥5) bone metastases who required the aid of a walker to ambulate. Without treatment, his treating physician predicted he would survive 6 months. Interventions and outcomes: The patient initially responded well to treatment with ADT, but during the 80-89th week of treatment he developed castration resistance. ADT was then discontinued. He subsequently began practicing Falun Gong (FLG) as an alternative form of care. Within one year of constant practice, he became able to walk independently, his bone metastases disappeared, and he also enjoyed better psychosocial functioning. His treating physician assessed that his prostate malignancy was “clinically, under control” and “his overall functional status is excellent.” The patient survived a total of 263 weeks (61.4 months) post diagnosis, including 174 weeks (40.6 months) after developing castration resistance. Conclusion: This castration-resistant terminal prostate cancer patient gained significant clinical benefits after practicing Falun Gong.
Self-Confidence and Unraveling in Matching Markets
Authors: Dargnies Marie-Pierre , Hakimov Rustamdjan , Kübler Dorothea 
Published: October 2019

We document experimentally how biased self-assessments affect the outcome of labor markets. In the experiments, we exogenously manipulate the self-confidence of participants in the role of workers regarding their relative performance by employing hard and easy real-effort tasks. Participants in the role of firms can make offers before information about the workers’ performance has been revealed. Such early offers by firms are more often accepted by workers when the real-effort task is hard than when it is easy. We show that the treatment effect works through a shift in beliefs; that is, under-confident agents are more likely to accept early offers than overconfident agents. The experiment identifies a behavioral determinant of unraveling, namely biased self-assessments. The treatment with the hard task entails more unraveling and thereby leads to lower efficiency and less stability, and it shifts payoffs from high- to low-quality firms. This paper was accepted by Uri Gneezy, behavioral economics.
A Mechanism Design Approach to Vendor Managed Inventory
Authors: Kadiyala Bharadwaj , Özer Özalp , Bensoussan Alain 
Published: October 2019

This paper studies an inventory management problem faced by an upstream supplier that is in a collaborative agreement, such as vendor-managed inventory (VMI), with a retailer. A VMI partnership provides the supplier an opportunity to manage inventory for the supply chain in exchange for point-of-sales (POS)- and inventory-level information from the retailer. However, retailers typically possess superior local market information and as has been the case in recent years, are able to capture and analyze customer purchasing behavior beyond the traditional POS data. Such analyses provide the retailer access to market signals that are otherwise hard to capture using POS information. We show and quantify the implication of the financial obligations of each party in VMI that renders communication of such important market signals as noncredible. To help institute a sound VMI collaboration, we propose learn and screen—a dynamic inventory mechanism—for the supplier to effectively manage inventory and information in the supply chain. The proposed mechanism combines the ability of the supplier to learn about market conditions from POS data (over multiple selling periods) and dynamically determine when to screen the retailer and acquire his private demand information. Inventory decisions in the proposed mechanism serve a strategic purpose in addition to their classic role of satisfying customer demand. We show that our proposed dynamic mechanism significantly improves the supplier’s expected profit and increases the efficiency of the overall supply chain operations under a VMI agreement. In addition, we determine the market conditions in which a strategic approach to VMI results in significant profit improvements for both firms, particularly when the retailer has high market power (i.e., when the supplier highly depends on the retailer) and when the supplier has relatively less knowledge about the end customer/market compared with the retailer. This paper was accepted by Gad Allon, operations management.
Frenemies in Platform Markets: Heterogeneous Profit Foci as Drivers of Compatibility Decisions
Authors: Adner Ron , Chen Jianqing , Zhu Feng 
Published: October 2019

We study compatibility decisions of two competing platform owners that generate profits through both hardware sales and royalties from content sales. We consider a game-theoretic model in which two platforms offer different standalone utilities to users. We find that incentives to establish one-way compatibility—the platform owner with smaller standalone value grants access to its proprietary content application to users of the competing platform—can arise from the difference in their profit foci. As the difference in the standalone utilities increases, royalties from content sales become less important to the platform owner with greater standalone value, but more important to the other platform owner. One-way compatibility can thus increase asymmetry between the platform owners’ profit foci and, given a sufficiently large difference in the standalone utilities, yields greater profits for both platform owners. We further show that social welfare is greater under one-way compatibility than under incompatibility. We also investigate how factors such as exclusive content and hardware-only adopters affect compatibility incentives. This paper was accepted by Chris Forman, information systems.
Deem uma Chance à Ideologia – Notas Sobre o Poder Negligenciado nas Relações Internacionais | Give Ideology a Chance – Notes on that Neglected Power in International Relations
Authors: Borges Renato T. 
Published: October 2019

As notas que se seguem visam colaborar com as discussões a respeito do conceito de ideologia e do seu papel na formulação de política externa referentes aos estudos da área de Relações Internacionais. O artigo, uma breve introdução sem qualquer objetivo de esgotamento do tema, aponta as relações existentes entre o conceito abordado e o do nacionalismo, assim como afirma a impossibilidade das tentativas de separação das questões ideológicas do exercício do estadista e das ações do Estado no cenário internacional. As considerações finais ressaltam a importância do estudo da ideologia para a área e reservam um comentário do autor acerca do contexto atual da política (externa) brasileira.Palavras-chave: Ideologia; Nacionalismo; Política Externa.ABSTRACT The notes below are an effort to contribute to the discussions in the area of International Relations concerning the concept of ideology and its role in foreign policy-making. This brief introduction does not exhaust the object, but it intends to be a starting point for new studies on the nexus between ideology and nationalism, or even the indivisibility of the former as a variable in the exercise of statesmanship as well as in the behavior of a state in the international system. The final thoughts underline the importance of the study of ideology in IR and expose some comments about the actual context of Brazilian (foreign) policy.Keywords: Ideology; Nationalism; Foreign Policy.Recebido em 17 jan. 2019 | Aceito em 03 set. 2019
HIV Apheresis Tags (HIVAT) Aided Elimination of Viremia
Authors: Malecki Marek , Saetre Bianka 
Published: October 2019

Abstract: HIV viremia is the essential element for progression of an initial HIV infection into AIDS and death. The currently approved management relies primarily on chemotherapy repressing the HIV replication in the infected CD4+ cells, although with severe systemic adverse effects. The problem is that it does not physically eliminate viruses, which then not only keep infecting healthy cells of these patients, but also promote infectivions of other people.
La influencia mediterránea en el valle medio del Ebro durante la Primera Edad del Hierro: imitaciones de holmoi, soportes y thymiateria
Authors: Royo Guillén José Ignacio 
Published: October 2019

La aparición en varios poblados y necrópolis protohistóricos del valle medio del Ebro de unas piezas cerámicas tipologicamente asimilables a los Holmoi etruscos, junto a otros ejemplares de soportes cerámicos y Thymiateria metálicos, nos permite analizar su contexto material, cronológico y cultural, así como comprobar cómo los estímulos del comercio mediterráneo, no sólo se extendieron por la costa mediterránea y tierras aledañas, sino que a través del intercambio y de procesos de aculturación, las poblaciones indígenas del valle medio del Ebro muy pronto asimilaron dichos influjos, especialmente en lo que respecta a las élites sociales, al ritual relacionado con el banquete en el ámbito funerario y a los cambios en la vajilla relacionada con la comensalidad en el ámbito doméstico, al menos desde mediados del siglo VII hasta finales del siglo VI y primera mitad del V a.
Rituximab in steroid resistant nephrotic syndrome
Authors: Chaki Agomoni , Rahman Farhana , Arju Jahanara , Al Mamun Abdullah- , Jesmin Tahmina , Huque Sayed Saimul , Begum Afroza , Rahman Habibur , Uddin Goam Muin , Roy Ranjit Ranjan 
Published: October 2019

Background Nephrotic syndrome (NS) is one of the most common glomerular disease in children, characterized by massive proteinuria, hypoalbuminemia, dyslipidemia and edema. Steroid-resistant nephrotic syndrome (SRNS) and steroid-dependent nephrotic syndrome (SDNS) present challenges in pharmaceutical management. Patient need several immunosuppressant for optimal control, each of which has significant side effect and difficult to get desired results. Rituximab (RTX) is a monoclonal antibody that targets B cells and has been shown to be effective for patients with SRNS and SDNS.
Objective To see efficacy of RTX in pediatric patients with SRNS.
Method This retrospective study took place in Pediatric Nephrology Department of Bangabandhu Sheikh Mujib Medical University from July 2017 to June 2019. Patients diagnosed with SRNS who were treated with RTX and followed up for 6 months were enrolled in this study. Primary endpoint was achievement of remission after rituximab infusion; secondary endpoint was relapse-free survival rate in 6 months period following rituximab infusion.
Results Total 7 patients were recruited in this study. Among them 4 were male. Clinical and lab parameters of all patients before and after RTX were compared. Complete remission achieved in 4/7 patients, partial remission in 2/7 patients and no response in 1/7 patient. Mean number of relapse in 3 patients before RTX infusion was 3.67 (SD 0.57) and after 0.33 (SD 0.00) (P=0.038).
Conclusion RTX is a biological agent that is effective and promising drug in children with SRNS. Rituximab is useful to induce and maintain remission.
Growth of HIV-exposed infants from birth to 6 months in the prevention of mother-to-child transmission program
Authors: Priskila Maria , Kumarawati Ketut Dewi , Purniti Ni Putu Siadi 
Published: October 2019

Background Human immunodeficiency virus (HIV) infection is a global health issue. Most cases of HIV infection in children are acquired through transmission from HIV-infected mothers. Maternal HIV infection affects infant growth.
Objective To evaluate the first six months of growth in HIV-exposed infants born to mothers in the prevention of mother-to-child transmission (PMTCT) program.
Methods This prospective cohort study was done in 40 HIV-exposed infants born in Sanglah General Hospital, Bali. Subjects’ underwent weight and length measurements at birth and monthly for 6 months. Data analyses used were repeated ANOVA test with Bonferonni post-hoc analysis for normally distributed data and Friedman test with Wilcoxon post-hoc analysis for abnormally distributed data. Correlations between birth weight and length to weight and length at 6 months of age were analyzed with Spearman’s test.
Results Subjects’ mean birth weight was 2,900 (SD 546) grams and median birth length was 48 (range 36-52) cm. Subjects’ body weight and length increased monthly throughout the measurement period (P<0.001). There was a strong negative correlation between birth weight and infant weight gain at 6 months of age (r=-0.678), and a moderate negative correlation between birth length and infant length gain at 6 months of age (r=-0.564).
Conclusion HIV-exposed infants born to mothers in the PMTCT program have a significant body weight and body length growth in the first 6 months of life, and followed general WHO weight and length curves for age.
Multi-site performance evaluation and Sigma metrics of 20 assays on the Atellica chemistry and immunoassay analyzers
Authors: Fasano Tommaso , Bedini Jose Luis , Fle Pierre-Antoine , Jlaiel Malik , Hubbert Karl , Datta Harish , Chicha-Cattoir Valerie , Mansour Hayfa , Mira Aurea , de la Presa Bernardino González , Rico Nayra , de Pedro Maria Sanz , Diaz-Garzon Jorge , Buño Soto Antonio , Vecchia Luigi , Peoc’h Katell 
Published: October 2019

Abstract

Background
The Atellica Solution comprises chemistry (CH) and immunoassay (IM) analyzers. Recently, six early adopter clinical laboratories across Europe evaluated the analytical performance of 20 CH and IM assays. To measure analytical performance quality, Sigma metrics were calculated for individual-site and pooled-site results.

Methods
Precision, detection capability, linearity, and method comparison studies were performed according to Clinical Laboratory Standards Institute protocols. Global Sigma metrics across sites were calculated from pooled data at the medical decision level using total allowable error (TEa) goals from CLIA for CH assays, and TEa goals from RiliBÄK for IM assays; and, the equation:
Sigma metrics=%TEa–%bias/%CV.
A pooled %CV was calculated by combining the imprecision obtained from individual sites. Bias calculations were performed against the ADVIA Chemistry system or ADVIA Centaur system using Deming regression analysis (Passing-Bablok regression for electrolytes) on the pooled-site data. The 103 individual-site Sigma metric calculations used individual-site imprecision and pooled-bias.

Results
The limits of blank and detection results agreed with the manufacturer’s claims. Most assays were linear across the assay range tested. Pooled Sigma metrics were good or better (>4 Sigma) for 18 of 20 assays; and, acceptable for urea nitrogen (3.1) and sodium (3.9), the latter values attributable to higher imprecision at one of five sites.

Conclusions
Sigma metrics for data generated across multiple real-world sites evaluating the Atellica Solution demonstrated good or better performance of greater than 4 Sigma for 18 of 20 assays tested. Overall, results verified the manufacturer’s claims that methods were fit for use in clinical laboratories.
Applying mass spectrometry-based assays to explore gut microbial metabolism and associations with disease
Authors: Heaney Liam M. 
Published: October 2019

Abstract
The workings of the gut microbiome have gained increasing interest in recent years through the mounting evidence that the microbiota plays an influential role in human health and disease. A principal focus of this research seeks to further understand the production of metabolic by-products produced by bacteria resident in the gut, and the subsequent interaction of these metabolites on host physiology and pathophysiology of disease. Gut bacterial metabolites of interest are predominately formed via metabolic breakdown of dietary compounds including choline and ʟ-carnitine (trimethylamine N-oxide), amino acids (phenol- and indole-containing uremic toxins) and non-digestible dietary fibers (short-chain fatty acids). Investigations have been accelerated through the application of mass spectrometry (MS)-based assays to quantitatively assess the concentration of these metabolites in laboratory- and animal-based experiments, as well as for direct circulating measurements in clinical research populations. This review seeks to explore the impact of these metabolites on disease, as well as to introduce the application of MS for those less accustomed to its use as a clinical tool, highlighting pertinent research related to its use for measurements of gut bacteria-mediated metabolites to further understand their associations with disease.
Crashworthiness performance of stiffened bottom tank structure subjected to impact loading conditions: Ship-rock interaction
Authors: Rio Prabowo Aditya , Sohn Jung Min , Putranto Teguh 
Published: October 2019

Abstract
Shipping time, cargo handling and quality as well as operational cost are main aspects of success in trading and shipping, which leads to high demand for ship safety. During freight shipping is conducted for various cargoes, the ship structure is subjected to numbers of loads, which several of them have been predicted during ship design. Nevertheless, incidental type in form of impact load can deliver massive blow to ship safety and cause immense loss. This phenomenon may be worse than initial condition if structure of chemical-oil carrier experiences impact, which possibly evokes environmental damage to maritime territory. This work is addressed to assess crashworthiness performance of structural part, i.e. bottom tank of chemical carrier. This part is one of center point of oil spill during occurrence of the impact load. The loading conditions are defined as configuration of interaction between ship structure and rock when the ship is stranded on shallow water. A series of data observations produced by finite element analysis (FEA) provide a prediction regarding local member’s motions during the rock breaches lower parts of the bottom tank. Consequences of the plate towards failure are quantified to obtain effect of the selected impact loading conditions to directly involved (main) member and other affected local member.
Mechanical characteristics, as well as physical-and-chemical properties of the slag-filled concretes, and investigation of the predictive power of the metaheuristic approach
Authors: Borodin Kirill , Zhangabayuly Zhangabay Nurlan 
Published: October 2019

Abstract
Our article is devoted to development and verification of the metaheuristic optimisation algorithm in the course of selection of the compositional proportions of the slag-filled concretes. The experimental selection of various compositions and working modes, which ensure one and the same fixed level of a basic property, is the very labour-intensive and time-consuming process. This process cannot be feasible in practice in many situations, for example, in the cases, where it is necessary to investigate composite materials with equal indicators of resistance to aggressive environments or with equal share of voids in the certain range of dimensions. There are many similar articles in the scientific literature. Therefore, it is possible to make the conclusion on the topicality of the above-described problem. In our article, we will consider development of the methodology of the automated experimental-and-statistical determination of optimal compositions of the slag-filled concretes. In order to optimise search of local extremums of the complicated functions of the multi-factor analysis, we will utilise the metaheuristic optimisation algorithm, which is based on the concept of the swarm intelligence. Motivation in respect of utilisation of the swarm intelligence algorithm is conditioned by the absence of the educational pattern, within which it is not necessary to establish a certain pattern of learning as it is necessary to do in the neural-network algorithms. In the course of performance of this investigation, we propose this algorithm, as well as procedure of its verification on the basis of the immediate experimental verification.
The linguistic sources of offense of taboo terms in German Sign Language
Authors: Loos Cornelia , Cramer Jens-Michael , Napoli Donna Jo 
Published: October 2019

AbstractTaboo terms offer a playground for linguistic creativity in language after language, and sign languages form no exception. The present paper offers the first investigation of taboo terms in sign languages from a cognitive linguistic perspective. We analyze the linguistic mechanisms that introduce offense, focusing on the combined effects of cognitive metonymy and iconicity. Using the Think Aloud Protocol, we elicited offensive or crass signs and dysphemisms from nine signers. We find that German Sign Language uses a variety of linguistic means to introduce and enhance offense, many of which rely on iconic properties of the taboo sign. In conjunction with cross-linguistically common metonymic word-formation strategies, the degree of visual explicitness of a sign increases its potential to offend. Semantically similar taboo signs based on the same metonymic anchor but differing in their degree of iconicity also differ in offensiveness. This allows for creating dysphemisms and euphemisms via phonological changes to a sign. We further show that embodiment creates modality-enhanced ‘vicarious embarrassment’ in the viewer that results in the respective signs being judged obscene or offensive. Further, lexical blending and non-manual enhancement play a role in the creation of dysphemisms in DGS. Lastly, we propose that iconicity as a cognitive structuring principle of linguistic expressions constrains the possible semantic extensions of iconic taboo terms.
Improvement of the Temperature Parametric (TP) Method for Fast Tracking of Maximum Power Point in Photovoltaic Modules
Authors: El Mentaly Lahcen , Amghar Abdellah , Sahsah Hassan 
Published: October 2019

Abstract
In this work we have presented a generalization of the Temperature Parametric (TP) Method which is based on the detection of the maximum power point by the prediction of the corresponding optimal voltage. This operating voltage is determined by the continuous measurement of the ambient temperature and solar irradiation. This new approach is based on a 3D linear regression model linking these quantities and which allows to our method to realize the maximum power point tracking in real time. The simulation shows that this new technique has a better MPPT efficiency compared to Hill Climbing technique.
Retrieving Experience: On the Phenomenology of Experience in Hegel and Kierkegaard, Arendt and Gadamer
Authors: Holst Jonas 
Published: October 2019

Abstract
The purpose of the present contribution is to develop an understanding of experience that accounts for its need to be continuously uncovered and recovered in order to consolidate itself. Through critical dialogue with modern phenomenological and hermeneutical traditions I posit that this consolidation process proves porous and discontinuous as experience contains caesuras and limits, which break open and even fracture what is already known by individual consciousness so as to make room for something new to appear over the horizon. Thinking about how to engage with the phenomena given in experience draws us into a dynamic movement at the limits of singular subjectivity and the world which transcends it to all sides. After following and exploring this movement, it remains a question, which will be discussed in the end, whether all experience can be retrieved.