bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Structure Design and Process Analysis for a Metrorological Monitoring Device Based on GIS
Authors: Wang Ying 
Published: March 2020

Abstract
A kind of meteorological monitoring device based on geographic information system (GIS) is studied in this paper, which belongs to the field of meteorological monitoring technology. The device include base, turntable, themometer shelter, roof, bracket and processor. Specifically, batteries and turntables motors are fixed on the left side and middle on the top respectively, and motors are fixed on the middle of the bottom. The device adopts a technological design of modularity design to ensure its scientific, rigorous and flexible. Its configuration can not only meet functional requirements of meteorological monitoring and the overall performance, but also its scalability can be achieved by adjusting the hardware configuration or adding a server to achieve a smooth upgrade of the device and expanding the overall performance of the device.
Research on Production Vehicle Evaluation Method of China VI OBD for Light-Duty Vehicles
Authors: Ling Jian , Li Yong , Li Jingyuan , Yan Yan 
Published: March 2020

Abstract
With the gradual tightening of light-duty vehicle emission regulations, the fault diagnosis function of the on-board diagnostic (OBD) system is constantly improving and the monitoring items are also increasing. The production vehicle evaluation (PVE) test problem of latest OBD certification in the China VI emission regulations for light vehicles is studied. Firstly, the working principle and development process of OBD system is introduced. Secondly, the PVE testing regulations and testing process of OBD system is analyzed. It covers standardized verification (J1), monitoring requirement verification (J2) and in-use monitoring performance verification (J3). Finally, in order to improve the efficiency of PVE testing for such a large number of faults, a faults classification method based on fault type and function is proposed. OBD faults can be simplified into the six categories, which include circuit fault, tool performance fault, hardware performance fault, bus communication fault and exemption test fault. The simulation method of corresponding fault is introduced and analyzed as well.
Study on the Appropriate Size of Scale Breeding Family Farms
Authors: He Zhengtao 
Published: March 2020

Abstract
Scale-breeding family farms can meet the demand of meat market and increase the farmers’ income. However, they may cause serious environmental problems to some extent if the waste is not properly handled. In this paper, the appropriate scale of scale breeding family farms was studied from the circular economy theory. Results show that the resource loss rate of middle-scale family farms is lowest among three kinds of scale-breeding family farms. Therefore, the middle-scale should be chosen as optimistic size for sustainable development of agricultural economy in China.
FE Analysis on the Thermoforming Behaviour of Large Spherical PMMA Panelapplied in JUNO
Authors: Qian Xiaohui , Ma Xiaoyan , Heng Yuekun , Xiao Jianxia , Zhang Gaofeng 
Published: March 2020

Abstract
Jiangmen Underground Neutrino Observation (JUNO) mainly focuses on determining neutrino mass hierarchy. The central detector is one of the keys to JUNO experiment, which is a spherical liquid scintillator detector with 20 kton target mass. The target vessel of the central detector is a huge acrylic vessel with a diameter of 35.4 m. Its construction will certainly face many enormous challenges and difficulties. This paper introduces the thermoforming process for huge acrylic spherical panel, which is a very important step in panel production. The effect of temperature on panel’s curvature during thermoforming is discussed. The temperature field and thermal deformation of the panel during thermoforming are analysed by finite element method. The temperature field affects the panel’s shape and cause its radius smaller than the thermoforming mold’s. The paper presents some suggestions on improving the shape of spherical panel. The temperature at concave and convex surfaces of panel should be controlled as equal as possible during thermoforming. The other method to get a spherical panel with design radius is increasing the forming mold’s radius appropriately.
Experimental Research on Anchoring Performance of Chemical Anchor Bolt in Building Curtain Wall Engineering
Authors: Xu Chengxiang , Zhou Bingyang , Peng Sheng 
Published: March 2020

Abstract
To study the anchoring performance of chemical anchor bolts in building curtain wall, anchoring performance affected by chemical anchoring in concrete grade and anchor bolt diameter were considered. Based on the existing code, 48 standard specimens were made. After analysing the drawing force and the load-displacement curve, the results revealed that when the concrete strength grades are the same, the drawing force of specimen increases while the increasing of chemical anchor bolt diameter; when the chemical anchor bolts have the same diameter, the drawing force of each specimen increases while the increasing of the concrete strength grades; when the concrete strength grade is C40 and the chemical anchor bolt diameter is M14, the concrete splitting damage degree of specimen is the weakest.
Surfaces—topography and topology
Authors: Wolf Gert W 
Published: March 2020

Abstract
ISO 25178-2 specifies areal field parameters as well as areal feature parameters. While for the first group the whole set of points defining a scale-limited surface is considered, for the second group only a subset of surface features is taken into account. As a consequence, an adequate data structure for surface characterisation in combination with an appropriate method for surface simplification are required. Three data structures for surface characterisation, namely, Morse-Smale complexes, weighted surface networks and change trees are discussed. Hereafter, the focus is laid on approaches for determining the relevance of topological features with respect to surface topography. Another topic of interest is surface simplification, i.e. the process of deriving from an original surface a second surface of decreased complexity, but with its structural properties being retained. Within the geosciences this concept is associated with the transition from large-scale maps to small-scale maps, whereas in the technical sciences it corresponds to the reduction of measurement noise. From a topological point of view, a theorem proven by Matsumoto may be regarded as the core theorem with respect to surface simplification. Its combination with the two concepts of relevance of a topological feature and degree of simplicity represents the basis of a formal procedure for surface simplification as required in ISO 25178-2 and ISO 16610-85.
Power and punishment influence negotiations over parental care
Authors: Barbasch Tina A , Alonzo Suzanne H , Buston Peter M 
Published: March 2020

AbstractAsymmetries in power (the ability to influence the outcome of conflict) are ubiquitous in social interactions because interacting individuals are rarely identical. It is well documented that asymmetries in power influence the outcome of reproductive conflict in social groups. Yet power asymmetries have received little attention in the context of negotiations between caring parents, which is surprising given that parents are often markedly different in size. Here we built on an existing negotiation model to examine how power and punishment influence negotiations over care. We incorporated power asymmetry by allowing the more-powerful parent, rank 1, to inflict punishment on the less-powerful parent, rank 2. We then determined when punishment will be favored by selection and how it would affect the negotiated behavioral response of each parent. We found that with power and punishment, a reduction in one parent’s effort results in partial compensation by the other parent. However, the degree of compensation is asymmetric: the rank 2 compensates more than the rank 1. As a result, the fitness of rank 1 increases and the fitness of rank 2 decreases, relative to the original negotiation model. Furthermore, because power and punishment enable one parent to extract greater effort from the other, offspring can do better, that is, receive more total effort, when there is power and punishment involved in negotiations over care. These results reveal how power and punishment alter the outcome of conflict between parents and affect offspring, providing insights into the evolutionary consequences of exerting power in negotiations.
Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs†
Authors: Wang Shanshan , Lawless John , Zheng Zhengui 
Published: March 2020

AbstractGenital tubercle has bisexual potential before sex differentiation. Females exposed to androgen during sex differentiation show masculinized external genitalia, but the effects of different androgens on tubular urethral and penile formation in females are mostly unknown. In this study, we compared the masculinization effects of commonly used androgens methyltestosterone, dihydrotestosterone, and testosterone on the induction of penile formation in females. Our results suggested that prenatal treatment with low doses of methyltestosterone, but not same doses of dihydrotestosterone or testosterone, could induce penile formation in female mice. The minimum dose of dihydrotestosterone and testosterone for inducing tubular urethral formation in female mice was, respectively, 50 and 20 times higher than that of methyltestosterone. In vivo methyltestosterone treatment induced more nuclear translocation of androgen receptors in genital tubercles of female mice, affected Wnt signaling gene expressions, and then led to similar patterns of cell proliferation and death in developing genital tubercles to those of control males. We further revealed that low-dose methyltestosterone, but not same dose of dihydrotestosterone or testosterone, treatment induced penile formation in female guinea pigs. Exposure of female mouse genital tubercle organ culture to methyltestosterone, dihydrotestosterone, or testosterone could induce nuclear translocation of androgen receptors, suggesting that the differential effect of the three androgens in vivo might be due to the hormonal profile in mother or fetus, rather than the local genital tissue. To understand the differential role of these androgens in masculinization process involved is fundamental to androgen replacement therapy for diseases related to external genital masculinization.
CHTF18 ensures the quantity and quality of the ovarian reserve†
Authors: Holton Rebecca A , Harris Abigail M , Mukerji Barenya , Singh Tanu , Dia Ferdusy , Berkowitz Karen M 
Published: March 2020

AbstractThe number and quality of oocytes, as well as the decline in both of these parameters with age, determines reproductive potential in women. However, the underlying mechanisms of this diminution are incompletely understood. Previously, we identified novel roles for CHTF18 (Chromosome Transmission Fidelity Factor 18), a component of the conserved Replication Factor C-like complex, in male fertility and gametogenesis. Currently, we reveal crucial roles for CHTF18 in female meiosis and oocyte development. Chtf18−/− female mice are subfertile and have fewer offspring beginning at 6 months of age. Consistent with age-dependent subfertility, Chtf18−/− ovaries contain fewer follicles at all stages of folliculogenesis than wild type ovaries, but the decreases are more significant at 3 and 6 months of age. By 6 months of age, both primordial and growing ovarian follicle pools are markedly reduced to near depletion. Chromosomal synapsis in Chtf18−/− oocytes is complete, but meiotic recombination is impaired resulting in persistent DNA double-strand breaks, fewer crossovers, and early homolog disjunction during meiosis I. Consistent with poor oocyte quality, the majority of Chtf18−/− oocytes fail to progress to metaphase II following meiotic resumption and a significant percentage of those that do progress are aneuploid. Collectively, our findings indicate critical functions for CHTF18 in ensuring both the quantity and quality of the mammalian oocyte pool.
Paths to low-cost hydrogen energy at a scale for transportation applications in the USA and China via liquid-hydrogen distribution networks
Authors: Li Xianming Jimmy , Allen Jeffrey D , Stager Jerad A , Ku Anthony Y 
Published: March 2020

Abstract
The cost of delivered H2 using the liquid-distribution pathway will approach $4.3–8.0/kg in the USA and 26–52 RMB/kg in China by around 2030, assuming large-scale adoption. Historically, hydrogen as an industrial gas and a chemical feedstock has enjoyed a long and successful history. However, it has been slow to take off as an energy carrier for transportation, despite its benefits in energy diversity, security and environmental stewardship. A key reason for this lack of progress is that the cost is currently too high to displace petroleum-based fuels. This paper reviews the prospects for hydrogen as an energy carrier for transportation, clarifies the current drivers for cost in the USA and China, and shows the potential for a liquid-hydrogen supply chain to reduce the costs of delivered H2. Technical and economic trade-offs between individual steps in the supply chain (viz. production, transportation, refuelling) are examined and used to show that liquid-H2 (LH2) distribution approaches offer a path to reducing the delivery cost of H2 to the point at which it could be competitive with gasoline and diesel fuel.
Structure–Function Connectomics Reveals Aberrant Developmental Trajectory Occurring at Preadolescence in the Autistic Brain
Authors: He Changchun , Chen Huafu , Uddin Lucina Q , Erramuzpe Asier , Bonifazi Paolo , Guo Xiaonan , Xiao Jinming , Chen Heng , Huang Xinyue , Li Lei , Sheng Wei , Liao Wei , Cortes Jesus M , Duan Xujun 
Published: March 2020

Abstract
Accumulating neuroimaging evidence shows that age estimation obtained from brain connectomics reflects the level of brain maturation along with neural development. It is well known that autism spectrum disorder (ASD) alters neurodevelopmental trajectories of brain connectomics, but the precise relationship between chronological age (ChA) and brain connectome age (BCA) during development in ASD has not been addressed. This study uses neuroimaging data collected from 50 individuals with ASD and 47 age- and gender-matched typically developing controls (TDCs; age range: 5–18 years). Both functional and structural connectomics were assessed using resting-state functional magnetic resonance imaging and diffusion tensor imaging data from the Autism Brain Imaging Data Exchange repository. For each participant, BCA was estimated from structure–function connectomics through linear support vector regression. We found that BCA matched well with ChA in TDC children and adolescents, but not in ASD. In particular, our findings revealed that individuals with ASD exhibited accelerated brain maturation in youth, followed by a delay of brain development starting at preadolescence. Our results highlight the critical role of BCA in understanding aberrant developmental trajectories in ASD and provide the new insights into the pathophysiological mechanisms of this disorder.
The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4
Authors: Witte Alexander , Rohlfing Anne-Katrin , Dannenmann Benjamin , Dicenta Valerie , Nasri Masoud , Kolb Kyra , Sudmann Jessica , Castor Tatsiana , Rath Dominik , Borst Oliver , Skokowa Julia , Gawaz Meinrad 
Published: March 2020

Abstract

Aims
Beyond classical roles in thrombosis and haemostasis, it becomes increasingly clear that platelets contribute as key players to inflammatory processes. The involvement of platelets in these processes is often mediated through a variety of platelet-derived chemokines which are released upon activation and act as paracrine and autocrine factors. In this study, we investigate CXCL14, a newly described platelet chemokine and its role in thrombus formation as well as monocyte and platelet migration. In addition, we examine the chemokine receptor CXCR4 as a possible receptor for CXCL14 on platelets. Furthermore, with the use of artificially generated platelets derived from induced pluripotent stem cells (iPSC), we investigate the importance of CXCR4 for CXCL14-mediated platelet functions.

Methods and results
In this study, we showed that CXCL14 deficient platelets reveal reduced thrombus formation under flow compared with wild-type platelets using a standardized flow chamber. Addition of recombinant CXCL14 normalized platelet-dependent thrombus formation on collagen. Furthermore, we found that CXCL14 is a chemoattractant for platelets and mediates migration via CXCR4. CXCL14 promotes platelet migration of platelets through the receptor CXCR4 as evidenced by murine CXCR4-deficient platelets and human iPSC-derived cultured platelets deficient in CXCR4. We found that CXCL14 directly interacts with the CXCR4 as verified by immunoprecipitation and confocal microscopy.

Conclusions
Our results reveal CXCL14 as a novel platelet-derived chemokine that is involved in thrombus formation and platelet migration. Furthermore, we identified CXCR4 as principal receptor for CXCL14, an interaction promoting platelet migration.
Anomalous aortic origin of coronary arteries: an alternative to the unroofing strategy
Authors: Gaillard Maïra , Pontailler Margaux , Danial Pichoy , Moreau de Bellaing Anne , Gaudin Régis , du Puy-Montbrun Leonora , Murtuza Bari , Haydar Ayman , Malekzadeh-Milani Sophie , Bonnet Damien , Vouhé Pascal , Raisky Olivier 
Published: March 2020

Abstract

OBJECTIVES

Anomalous aortic origin of a coronary artery (AAOCA) is the second leading cause of sudden death in children and young adults. The most threatening anatomy is an interarterial and an intramural course, both probably involved in ischaemic phenomena and sudden death. The treatment of interarterial AAOCA remains controversial. Most of the published studies describe the results of the unroofing technique. Our study aims to evaluate the results of a different surgical approach.

METHODS
From 2005 to 2019, 61 patients were operated on for an interarterial AAOCA (median age 14.7 years). Forty patients had a right AAOCA, and 21 patients had a left AAOCA including 5 patients with intraseptal course. Seventy percent of patients were symptomatic. Five patients had an aborted sudden cardiac death. Two surgical techniques were used: an ‘anatomical’ repair for 35 patients (15 left and 22 right AAOCA) or a coronary translocation with creation of a neo-ostia in 19 patients (1 left and 18 right AAOCA). The 5 left AAOCA patients with an intra-septal course required a complete release of the coronary artery from the septum.

RESULTS
There was no early or late postoperative death. Three patients had an acute postoperative ischaemic event. Two patients required immediate angioplasty and stenting: 1 patient (7 years) with a hypoplastic right AAOCA and 1 patient (66 years) for inadequate tailoring after septal release. The third patient required an immediate surgical revision (H-2) for left AAOCA thrombosis at the level of the pericardial patch with full myocardial recovery at discharge. During follow-up, 1 patient with right AAOCA translocation and chronic chest pain required subsequent stenting and finally a coronary artery bypass grafting 2 years after initial surgery. One patient who had an asymptomatic mild right coronary stenosis 1 year after anatomical repair was successfully treated by angioplasty alone. All patients but 1 who underwent coronary translocation are totally asymptomatic. All patients with anatomical repair or septal release are free from ischaemic symptoms.

CONCLUSIONS
Anatomical repair might provide a better protective option for these patients. Unlike unroofing, it treats the entire intramural segment, relocates the ostium at the appropriate sinus level and corrects any acute take-off angle.
A putative placebo analysis of the effects of sacubitril/valsartan in heart failure across the full range of ejection fraction
Authors: Vaduganathan Muthiah , Jhund Pardeep S , Claggett Brian L , Packer Milton , Widimský Jiri , Seferovic Petar , Rizkala Adel , Lefkowitz Martin , Shi Victor , McMurray John J V , Solomon Scott D 
Published: March 2020

Abstract

Aims
The PARADIGM-HF and PARAGON-HF trials tested sacubitril/valsartan against active controls given renin–angiotensin system inhibitors (RASi) are ethically mandated in heart failure (HF) with reduced ejection fraction and are used in the vast majority of patients with HF with preserved ejection fraction. To estimate the effects of sacubitril/valsartan had it been tested against a placebo control, we made indirect comparisons of the effects of sacubitril/valsartan with putative placebos in HF across the full range of left ventricular ejection fraction (LVEF).

Methods and results
We analysed patient-level data from the PARADIGM-HF and PARAGON-HF trials (n = 13 194) and the CHARM-Alternative and CHARM-Preserved trials (n = 5050, candesartan vs. placebo). The rate ratio (RR) of sacubitril/valsartan vs. putative placebo was estimated by the product of the RR for sacubitril/valsartan vs. RASi and the RR for RASi vs. placebo. Total HF hospitalizations and cardiovascular death were analysed using the negative binomial method. Treatment effects were estimated using cubic spline methods by ejection fraction as a continuous measure. Across the range of LVEF, sacubitril/valsartan was associated with a RR 0.54 [95% confidence interval (CI) 0.45–0.65] for the recurrent primary endpoint compared with putative placebo (P &lt; 0.001). Treatment benefits of sacubitril/valsartan vs. putative placebo varied non-linearly with LVEF with attenuation of effects observed at LVEF above 60%. When analyzing data from PARADIGM-HF and CHARM-Alternative, the estimated risk reduction of sacubitril/valsartan vs. putative placebo was 48% (95% CI 35–58%); P &lt; 0.001. When analyzing data from PARAGON-HF and CHARM-Preserved (with LVEF ≥ 45%), the estimated risk reduction of sacubitril/valsartan vs. putative placebo was 29% (95% CI 7–46%); P = 0.013. Across the full range of LVEF, consistent effects were observed for time-to-first endpoints: first primary endpoint (RR 0.72, 95% CI 0.64–0.82), first HF hospitalization (RR 0.67, 95% CI 0.58–0.78), cardiovascular death (RR 0.76, 95% CI 0.64–0.89), and all-cause death (RR 0.83, 95% CI 0.71–0.96); all P &lt; 0.02.

Conclusion
This putative placebo analysis reinforces the treatment benefits of sacubitril/valsartan on risk of adverse cardiovascular events across the full range of LVEF, with most pronounced effects observed at a LVEF up to 60%.