bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting international marketing strategy in a digital era
Authors: Katsikeas Constantine , Leonidou Leonidas , Zeriti Athina 
Published: November 2019

Purpose
The purpose of this paper is to explore the opportunities and challenges facing firms in this new digital era concerning their international marketing strategy and examine how international marketing practices can be revisited in the light of these developments. Consideration is given to a range of relevant issues involved in the design and deployment of effective international marketing strategies using internet-enabled technologies. Such factors relate to internal company requirements, the external environmental situation, foreign market selection and entry, international marketing mix programs, and strategy implementation and control aspects.

Design/methodology/approach
A conceptual paper identifies, structures and presents systematically factors influencing international marketing strategy, implementation and control using digital technologies.

Findings
The authors point to the relevance and potentially important role that the deployment of online organizational resources and capabilities play in influencing foreign market selection and entry decisions and international marketing strategy choices, implementation and control. The authors thus explain how the use of digital technologies can facilitate the firm’s foreign market choices and the adoption of effective marketing programs, and offer insights into the adoption of digital tools in more effectively implementing and controlling the firm’s international marketing strategy.

Originality/value
The originality and value of this conceptual study is reflected in the identification and discussion of factors comprising the organizing framework of an international marketing strategy using internet-enabled technologies and in the examination of fruitful avenues of future investigation as a result of the need to redesign international marketing strategies in a new digital era.
What drives self-disclosure in mobile payment applications? The effect of privacy assurance approaches, network externality, and technology complementarity
Authors: Gong Xiang , Zhang Kem Z.K. , Chen Chongyang , Cheung Christy M.K. , Lee Matthew K.O. 
Published: November 2019

Purpose
Drawing on the control agency theory and the network effect theory, the purpose of this paper is to examine the effect of privacy assurance approaches, network externality and technology complementarity on consumers’ self-disclosure in mobile payment (MP) applications. The authors identify four types of privacy assurance approaches: perceived effectiveness of privacy setting, perceived effectiveness of privacy policy, perceived effectiveness of industry self-regulation and perceived effectiveness of government legislation. The research model considers how these privacy assurance approaches influence privacy concerns and consumers’ self-disclosure in MP applications under boundary conditions of network externality and technology complementarity.

Design/methodology/approach
An online survey with 647 sample users was conducted to empirically validate the model. The target respondents were current consumers of a popular MP application. The empirical data were analyzed by a structural equation modeling approach.

Findings
The empirical results reveal several major findings. First, privacy assurance approaches can effectively decrease privacy concerns, which ultimately formulates consumers’ self-disclosure in MP applications. Second, network externality and technology complementarity weaken the effect of perceived effectiveness of privacy setting on privacy concerns. Third, network externality and technology complementarity strengthen the relationship between perceived effectiveness of government legislation and privacy concerns, while they have non-significant interaction effect with perceived effectiveness of privacy policy and industry self-regulation on privacy concerns.

Practical implications
MP providers and stakeholders can harness the efficacy of privacy assurance approaches in alleviating privacy concerns and promoting consumers’ self-disclosure in MP applications.

Originality/value
The authors’ work contributes to the information privacy literature by identifying effective privacy assurance approaches in promoting consumers’ self-disclosure in MP applications, and by highlighting boundary conditions of these privacy assurance approaches.
The determinants of tax-haven use: evidence from Canada
Authors: Makni Yosra Fourati , Maaloul Anis , Dabbebi Rabeb 
Published: November 2019

Purpose
The purpose of this paper is to investigate the determinants of tax-haven use of publicly listed Canadian firms.

Design/methodology/approach
Based on alternative measures of tax havens (TH) and referring to a sample of 235 Canadian firms over the period of 2014–2015, probit-regression analyses are used to examine the determinants of tax-haven use.

Findings
The authors provide evidence that multinationality, intangible assets, thin capitalization, withholding taxes, equity-based management remuneration and tax fees paid to auditing firms are positively associated with TH use. Furthermore, the authors show that the variable relating to R&D intensity is positively associated with TH use. The authors also document that strong corporate-governance structures are negatively associated with TH use.

Research limitations/implications
This study is only limited to Canadian firms, so the results may not be generalizable to other countries.

Practical implications
The results may assist tax watchdogs in their efforts to understand the tax behavior held by Canadian firms. They may also be interesting for tax authorities in planning enforcement activities.

Originality/value
This study uses a sample from publicly listed financial and non-financial firms. It also uses various lists of TH published by various competent sources (IMF, 2000, 2007; TJN, 2005; OECD, 2012). The findings corroborate the recent media attention about the extensive use of TH by Canadian firms.
The impact of PHTPS on trip quality, trip value, satisfaction and word of mouth
Authors: Battour Mohamed , Rahman Muhammad Khalilur , Rana Md. Sohel 
Published: November 2019

PurposeThe study aims to determine the impact of non-Muslim tourists’ perception of halal tourism products and services (PHTPS) on trip quality, trip value, satisfaction and word of mouth (WOM) towards halal tourism destination.Design/methodology/approachA total of 375 non-Muslim tourists were surveyed in Malaysia using partial least square technique.FindingsThe findings showed that PHTPS has a significant impact on all four dimensions. The strongest relationship was found between PHTPS and trip quality, followed by PHTPS–WOM, PHTPS–satisfaction and PHTPS–trip value.Originality/valueThis study provides new insights into the theory and practice of non-Muslim tourists’ PHTPS and WOM towards halal tourism destination. The findings are valuable to tourism operators, managers and marketers with the understanding and responsibility to develop halal tourism products and services from non-Muslim tourists’ insights.
A synthetic peptide analog of in silico‐predicted immunogenic epitope unique to dengue virus serotype 2 NS1 antigen specifically binds immunoglobulin G antibodies raised in rabbits
Authors: Guevarra Leonardo A. , Boado Kathleen Joyce O. , Ceñidoza Fidel Bryan B. , Imbao Ma. Rio Lauren M. , Sia Michelle Joy G. , Dalmacio Leslie Michelle M. 
Published: November 2019

AbstractDevelopment of a serotyping‐capable dengue detection test is hampered by the absence of an identified unique marker that can detect specific dengue virus (DENV) serotype. In the current commercially available antibody‐capture diagnostic methods, immobilized nonstructural 1 (NS1) antigen indiscriminately binds and detects immunoglobulin M or immunoglobulin G against any serotype, thus limiting its capability to distinguish existing serotypes of dengue. Identification of dengue serotype is important because certain serotypes are associated with severe forms of dengue as well as dengue hemorrhagic fever. In this study, we aimed to identify an immunogenic epitope unique to DENV2 NS1 antigen and determine the binding specificity of its synthetic peptide mimotope to antibodies raised in animal models. Selection of a putative B‐cell epitope from the reported DENV2 NS1 antigen was done using Kolaskar and Tongaonkar Antigenicity prediction, Emini surface accessibility prediction, and Parker hydrophilicity prediction available at the immune epitope database and analysis resource. Uniqueness of the B‐cell epitope to DENV2 was analyzed by BLASTp. Immunogenicity of the synthetic peptide analog of the predicted immunogenic epitope was tested in rabbits. The binding specificity of the antibodies raised in animals and the synthetic peptide mimotope was tested by indirect ELISA. A synthetic peptide analog comprising the unique epitope of DENV2 located at the 170th–183rd position of DENV2 NS1 was found to be immunogenic in animal models. The antipeptide antibody produced in rabbits showed specific binding to the synthetic peptide mimotope of the predicted unique DENV2 NS1 immunogenic epitope.
Transcriptional patterns ofEmiliania huxleyiin the North Pacific Subtropical Gyre reveal the daily rhythms of its metabolic potential
Authors: Hernández Limón María D. , Hennon Gwenn M. M. , Harke Matthew J. , Frischkorn Kyle R. , Haley Sheean T. , Dyhrman Sonya T. 
Published: November 2019

SummaryEmiliania huxleyiis a calcifying haptophyte, contributing to both the organic and inorganic marine carbon cycles. In marine ecosystems, light is a major driver of phytoplankton physiology and ultimately carbon flow through the ecosystem. Here, we analysed a Lagrangian time‐series of metatranscriptomes collected in the North Pacific Subtropical Gyre (NPSG) to examine howin situpopulations ofE.huxleyimodulate gene expression over day–night transitions. ManyE.huxleyicontigs had a diel expression pattern, with 61% of contigs clustering into modules with statistically significant diel periodicity. Contigs involved in processes that build up energy stores, like carbon fixation and lipid synthesis, peaked around dawn. In contrast, contigs involved in processes that released energy stores, like respiration and lipid degradation, peaked mid‐day and towards dusk. These patterns suggest an orchestrated cycle of building, then consuming energy stores inE.huxleyipopulations in the NPSG. Selected contigs related to the cell cycle also exhibited significant diel periodicity consistent with phased modulations of division observed in culture. Overall, these patterns of gene expression suggest a daily metabolic cascade that could contribute to both organic and inorganic carbon flow in this nutrient depleted ecosystem.
Supplétisme á partir du locuteur: le cas du latinagō/faciō/fiō
Authors: Julia Marie‐Ange 
Published: November 2019

AbstractThe first aim of this work is to investigate a particular suppletism in order to draw conclusions about the phenomenon as a whole. Suppletion is a complex phenomenon, which often involves more elements than are generally supposed. Thus the paradigmatic suppletion in Latin between the activefaciō« I do » and the passivefiō« I am done » is probably the result of a resolution of another suppletive pair between the roots ofagōandfaciō. It will be necessary to add to the well‐known morphological suppletion an actantial one and it will be important to determine its importance in the genesis of numerous suppletions. In this paper, we will try to link the phenomenon to the speaker and his/her role in the genesis of the grammar.
Emergency healthcare delivery for young adults during a planned mass gathering: A retrospective observational study
Authors: Crilly Julia , Ranse Jamie , Bost Nerolie , Donnelly Tonya , Timms Jo , Gilmour Kate , Aitken Michael , Johnston Amy 
Published: November 2019

AbstractObjectiveTo describe patient presentation characteristics and outcomes for people aged 16–18 years pre, during and post a planned youth mass gathering event (MGE): ‘Schoolies week’ on the Gold Coast, Queensland, Australia.MethodsThis was a retrospective observational study, including patient presentations by all young adults requiring care in the ED or in‐event health services (EHS) over a 21‐day period in 2014. Data analysis included descriptive and inferential statistics.ResultsA total of 1029 patient presentations were made by people aged 16–18 years to the ED and EHS over the 21‐day study period (139 pre, 695 during [275 in ED, 420 in EHS], 195 post Schoolies week). Some ED patient characteristics and outcomes varied between the pre, during and post Schoolies periods, such as patients age (P < 0.001), usual place of residence (P < 0.001) and not waiting for treatment (P = 0.015). Of the 24 375 registered MGE attendees, 420 (1.72% [95% confidence interval 1.57–1.89], 17.2/1000) presented for in‐event care. Most patients were allocated an Australasian Triage Scale category of 4 (n = 162, 65.6%), with toxicology related presentations (n = 169, 44.9%). Transportation to hospital was undertaken for seven MGE attendees (0.03% [95% confidence interval 0.01–0.06], 0.3/1000).ConclusionsEstablishment of an in‐event model of care for 1 week during Schoolies served as an effective hospital avoidance strategy for a planned youth MGE. Such in‐event models of care may be considered for other similar future MGE.
Corrupted ER‐mitochondrial calcium homeostasis promotes the collapse of proteostasis
Authors: Ashkavand Zahra , Sarasija Shaarika , Ryan Kerry C. , Laboy Jocelyn T. , Norman Kenneth R. 
Published: November 2019

AbstractAging and age‐related diseases are associated with a decline of protein homeostasis (proteostasis), but the mechanisms underlying this decline are not clear. In particular, decreased proteostasis is a widespread molecular feature of neurodegenerative diseases, such as Alzheimer's disease (AD). Familial AD is largely caused by mutations in the presenilin encoding genes; however, their role in AD is not understood. In this study, we investigate the role of presenilins in proteostasis using the model system Caenorhabditis elegans. Previously, we found that mutations in C. elegans presenilin cause elevated ER to mitochondria calcium signaling, which leads to an increase in mitochondrial generated oxidative stress. This, in turn, promotes neurodegeneration. To understand the cellular mechanisms driving neurodegeneration, using several molecular readouts of protein stability in C. elegans, we find that presenilin mutants have widespread defects in proteostasis. Markedly, we demonstrate that these defects are independent of the protease activity of presenilin and that reduction in ER to mitochondrial calcium signaling can significantly prevent the proteostasis defects observed in presenilin mutants. Furthermore, we show that supplementing presenilin mutants with antioxidants suppresses the proteostasis defects. Our findings indicate that defective ER to mitochondria calcium signaling promotes proteostatic collapse in presenilin mutants by increasing oxidative stress.
Bronchopulmonary and vascular anomalies are frequent in children with oesophageal atresia
Authors: Lejeune Stephanie , Le Mee Armelle , Petyt Laurent , Hutt Antoine , Sfeir Rony , Michaud Laurent , Fayoux Pierre , Deschildre Antoine , Gottrand Frederic , Thumerelle Caroline 
Published: November 2019

AbstractAimOesophageal atresia is frequently associated with other malformations, and our aim was to use computed tomography (CT) to explore intrathoracic malformations in patients with this condition.MethodThis was retrospective study of children aged 0‐16 with oesophageal atresia who were born in 1996‐2013 and followed up at the French reference centre for rare oesophageal diseases at the University of Lille. Computed tomography scans were available for 48 of the 234 patients during follow‐up visits, and these were reviewed by a thoracic radiologist.ResultsMore than two‐thirds of the scans were performed to explore persistent respiratory symptoms. We found that six patients had a pulmonary malformations: four lobar agenesis, one right pulmonary aplasia and one congenital cystic adenomatoid malformation. Computed tomography enabled us to diagnose unexpected thoracic malformations in 16 patients: four lobar agenesis, six arteria lusoria, five persistent left superior vena cava and one partial anomalous pulmonary venous return. It also confirmed the diagnoses of suspected malformations in five patients: one congenital cystic adenomatoid malformation, one pulmonary hypoplasia, two right‐sided aortic arches and one communicating bronchopulmonary foregut malformation.ConclusionIntrathoracic anomalies were frequently associated with oesophageal atresia, and contrast‐enhanced chest CT scans should be performed on patients with persistent respiratory symptoms.
Kinases as potential targets for treatment of pulmonary hypertension and right ventricular dysfunction
Authors: Weiss Astrid , Boehm Mario , Egemnazarov Bakytbek , Grimminger Friedrich , Savai Pullamsetti Soni , Kwapiszewska Grazyna , Schermuly Ralph T. 
Published: November 2019

Pulmonary hypertension (PH) is a progressive pulmonary vasculopathy that causes chronic right ventricular pressure overload and often leads to right ventricular failure. Various kinase inhibitors have been studied in the setting of PH and either improved or worsened the disease, highlighting the importance of understanding the specific role of the respective kinases in a spatiotemporal cellular context. In this review, we will summarize the knowledge on the role of kinases in PH and focus on druggable targets for which certain criteria are met: (a) deregulation of the kinase in PH; (b) small‐molecule inhibitors are available (e.g. from the oncology field); (c) preclinical studies have shown their efficacy in PH models; and (d) when available, therapeutic exploitation in human PH has been initiated. Along this line, clinical considerations such as personalized medicine approaches to predict therapy response and adverse side events such as cardiotoxicity together with their clinical management are discussed.LINKED ARTICLESThis article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc
Neurogenic differentiation factor 1 promotes colorectal cancer cell proliferation and tumorigenesis by suppressing the p53/p21 axis
Authors: Lei Ke , Li Wenfang , Huang Can , Li Yanjun , Alfason Leader , Zhao Hezhao , Miyagishi Makoto , Wu Shourong , Kasim Vivi 
Published: November 2019

AbstractNeurogenic differentiation factor 1 (NeuroD1) is a transcription factor critical for promoting neuronal differentiation and maturation. NeuroD1 is involved in neuroblastoma and medulloblastoma; however, its molecular mechanism in promoting tumorigenesis remains unclear. Furthermore, the role of NeuroD1 in non–neural malignancies has not been widely characterized. Here, we found that NeuroD1 is highly expressed in colorectal cancer. NeuroD1‐silencing induces the expression of p21, a master regulator of the cell cycle, leading to G2‐M phase arrest and suppression of colorectal cancer cell proliferation as well as colony formation potential. Moreover, NeuroD1‐mediated regulation of p21 expression occurs in a p53‐dependent manner. Through chromatin immunoprecipitation and point mutation analysis in the predicted NeuroD1 binding site of the p53 promoter, we found that NeuroD1 directly binds to the p53 promoter and suppresses its transcription, resulting in increased p53 expression in NeuroD1‐silenced colorectal cancer cells. Finally, xenograft experiments demonstrated that NeuroD1‐silencing suppresses colorectal cancer cell tumorigenesis potential by modulating p53 expression. These findings reveal NeuroD1 as a novel regulator of the p53/p21 axis, underscoring its importance in promoting non–neural malignancies. Furthermore, this study provides insight into the transcriptional regulation of p53.
Adult onset tubulo‐interstitial nephropathy in MT‐ND5‐related phenotypes
Authors: Bakis Hugo , Trimouille Aurélien , Vermorel Agathe , Redonnet Isabelle , Goizet Cyril , Boulestreau Romain , Lacombe Didier , Combe Christian , Martin‐Négrier Marie‐Laure , Rigothier Claire 
Published: November 2019

AbstractKidney is a highly adenosine triphosphate dependent organ in human body. Healthy and functional mitochondria are essential for normal kidney function. Clinical and genetic variability are the hallmarks of mitochondrial disorders. We report here the involvement of two MT‐ND5 pathogenic variants encoding for ND5 subunit of respiratory chain complex I, the m.13513G>A and the m.13514A>G, in adult‐onset kidney disease in three unrelated patients. The first patient had myopathy encephalopathy lactic acidosis and stroke syndrome, left ventricular hypertrophy with Wolff‐Parkinson‐White syndrome and tubulo‐interstitial kidney disease. The second presented Leber hereditary optic neuropathy associated with tubulo‐interstitial kidney disease. The third presented with an isolated chronic tubulo‐interstitial kidney disease. These mutations have never been associated with adulthood mitochondrial nephropathy. These case reports highlight the importance to consider mitochondrial dysfunction in tubulo‐interstitial kidney disease.
Immediate implant placement for a single anterior maxillary tooth with a facial bone wall defect: A prospective clinical study with a one‐year follow‐up period
Authors: Liu Renzhang , Yang Zhen , Tan Jianguo , Chen Li , Liu Hanqing , Yang Jianjun 
Published: November 2019

AbstractBackgroundClinical studies on immediate implant placement for a single anterior maxillary tooth with a facial bone wall defect are rarely reported.ObjectiveTo study the clinical outcomes of immediate implant placement combined with flap surgery, guided bone regeneration and non‐submerged healing for a single anterior maxillary tooth with a facial bone wall defect.Materials and MethodsForty‐five patients with a single failing tooth in the anterior maxillary region showing indications for extraction combined with a facial bone wall defect were treated by means of immediate implant placement combined with flap surgery, guided bone regeneration and non‐submerged healing. During this study, the implant survival rate, soft and hard tissue dimension changes, pink aesthetic score (PAS), and patient aesthetic satisfaction were assessed at 1, 6, and 12 months post‐operatively.ResultsAt 12 months post‐operatively, the survival rate of 45 implants was 100%. Mesial/distal papillary level reduction and midfacial soft tissue recession were measured as 0.53, 0.41, and 0.31 mm, respectively. The thickness of facial bone reduction measured by cone beam computed tomography was 0.94, 0.80, 0.85, 0.82, 0.45, and 0.41 mm at 6 different sites around the implant. The mean PAS and patient aesthetic satisfaction were determined to be 10.58% and 93%, respectively.ConclusionsThe proposed surgical procedure is a valuable treatment strategy as assessed by preliminary clinical outcomes.