bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valorization of Biomass-Derived Platform Molecules via Photoredox Sustainable Catalysis
Authors: Lin Qiong , Li Yue-Hua , Tang Zi-Rong , Xu Yi-Jun 
Published: August 2020

AbstractThe conversion of biomass into valuable chemicals has promise for application in biorefineries. Light-driven photoredox catalysis, with the typical features of green route and operation under mild conditions, is considered a promising strategy for renewable biomass or biomass-derived intermediates conversion into high-value-added chemical feedstocks. In this review, we strongly emphasize the recent advances in photocatalytic valorization of lignin model compounds and biomass-derived alcohols. We briefly summarize the advances in photocatalytic cleavage of the β-O-4 bond or C–C bond into usable chemicals in the lignin model. On the other hand, we clarify not only the hybrid system for cooperative biomass-relevant alcohols oxidation and hydrogen (H2) evolution but also the tunable accessibility to variation of the target products from the same alcohol reactant by catalyst design and optimization of reaction conditions. It is hoped that this review will inspire the rational design of photoredox catalysis-based systems toward efficient biomass-derived platform molecules valorization to obtain target-oriented valuable products.
RamA, a transcriptional regulator conferring florfenicol resistance in Leclercia adecarboxylata R25
Authors: Cheng Cong , Ying Yuanyuan , Zhou Danying , Zhu Licheng , Lu Junwan , Li Aifang , Bao Qiyu , Zhu Mei 
Published: August 2020

AbstractDue to the inappropriate use of florfenicol in agricultural practice, florfenicol resistance has become increasingly serious. In this work, we studied the novel florfenicol resistance mechanism of an animal-derived Leclercia adecarboxylata strain R25 with high-level florfenicol resistance. A random genomic DNA library was constructed to screen the novel florfenicol resistance gene. Gene cloning, gene knockout, and complementation combined with the minimum inhibitory concentration (MIC) detection were conducted to determine the function of the resistance-related gene. Sequencing and bioinformatics methods were applied to analyze the structure of the resistance gene-related sequences. Finally, we obtained a regulatory gene of an RND (resistance-nodulation-cell division) system, ramA, that confers resistance to florfenicol and other antibiotics. The ramA-deleted variant (LA-R25ΔramA) decreased the level of resistance against florfenicol and several other antibiotics, while a ramA-complemented strain (pUCP24-prom-ramA/LA-R25ΔramA) restored the drug resistance. The whole-genome sequencing revealed that there were five RND efflux pump genes (mdtABC, acrAB, acrD, acrEF, and acrAB-like) encoded over the chromosome, and ramA located upstream of the acrAB-like genes. The results of this work suggest that ramA confers resistance to florfenicol and other structurally unrelated antibiotics, presumably by regulating the RND efflux pump genes in L. adecarboxylata R25.
Thermodynamic investigation of SNG production based on dual fluidized bed gasification of biogenic residues
Authors: Bartik Alexander , Benedikt Florian , Lunzer Andreas , Walcher Constantin , Müller Stefan , Hofbauer Hermann 
Published: August 2020

AbstractNatural gas is an important commodity in the European energy market. The gasification of biogenic residues and the further reaction to a methane-rich gas represent a promising concept for the production of synthetic natural gas on a fossil-free basis. This paper investigates the thermodynamics of methanation in a fluidized bed reactor for different product gas compositions of the dual fluidized bed gasification technology. The investigated product gases range from conventional steam gasification, over CO2 gasification, to product gases from the sorption enhanced reforming process. All investigated product gases from conventional steam gasification show an understoichiometric composition and therefore require a proper handling of carbon depositions and a CO2 separation unit downstream of the methanation reactor. The product gas from CO2 gasification is considered disadvantageous for the investigated process, because it only exhibits a carbon utilization efficiency of 23%. Due to the high flexibility of the sorption enhanced reforming process, a nearly complete methanation of the carbonaceous species is possible without the need for a CO2 separation step or the addition of steam upstream of the methanation reactor. Furthermore, the carbon utilization efficiency is found to be between 36 and 38%, similar to the results for conventional steam gasification. Temperature and pressure variations allow a thermodynamically optimized operation, which can increase the performance of the methanation and lower the extent of gas upgrading for grid feed-in. Additionally, if a higher hydrogen content in the natural gas grid would be allowed, the overall process chain could be further optimized and simplified.
Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity
Authors: Chetia Swapnali , Borah Gaurab 
Published: August 2020

AbstractΔ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of striatal DA. Cannabidiol (CBD), with its anxiolytic and anti-psychotic property, is potent to ameliorate the THC-induced DAergic variations. Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products. With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release. Alongside the reported data, uses of cannabis as a therapeutic medium in a number of health complications are also being briefly reviewed. These evaluated reports led to an anticipation of additional research contradictory to the findings of THC and CBD activity in the brain DAergic system and their medical implementations as therapeutics.
Graphic Abstract
Risk factors for Covid-19 severity and fatality: a structured literature review
Authors: Wolff Dominik , Nee Sarah , Hickey Natalie Sandy , Marschollek Michael 
Published: August 2020

AbstractPurposeCovid-19 is a global threat that pushes health care to its limits. Since there is neither a vaccine nor a drug for Covid-19, people with an increased risk for severe and fatal courses of disease particularly need protection. Furthermore, factors increasing these risks are of interest in the search of potential treatments. A systematic literature review on the risk factors of severe and fatal Covid-19 courses is presented.MethodsThe review is carried out on PubMed and a publicly available preprint dataset. For analysis, risk factors are categorized and information regarding the study such as study size and location are extracted. The results are compared to risk factors listed by four public authorities from different countries.ResultsThe 28 records included, eleven of which are preprints, indicate that conditions and comorbidities connected to a poor state of health such as high age, obesity, diabetes and hypertension are risk factors for severe and fatal disease courses. Furthermore, severe and fatal courses are associated with organ damages mainly affecting the heart, liver and kidneys. Coagulation dysfunctions could play a critical role in the organ damaging. Time to hospital admission, tuberculosis, inflammation disorders and coagulation dysfunctions are identified as risk factors found in the review but not mentioned by the public authorities.ConclusionFactors associated with increased risk of severe or fatal disease courses were identified, which include conditions connected with a poor state of health as well as organ damages and coagulation dysfunctions. The results may facilitate upcoming Covid-19 research.
Development of muffins as dialysis snacks for patients undergoing hemodialysis: results of chemical composition and sensory analysis
Authors: Machado Jessica , Miyahira Roberta Fontanive , Marques Monica , Moura-Nunes Nathalia , Guimarães Renata Rangel , Zago Lilia , Santana Isabelle , Leite Junior Maurilo , Avesani Carla Maria 
Published: August 2020

Abstract
Objective
This study aimed to develop two non-industrial food products as financially accessible options to prevent and treat malnutrition in hemodialysis (HD) patients. These food products were developed and intended for use as dialysis snacks.

Methods
This is a cross-sectional and multi-step study. First, 183 adult HD patients (55 ± 14 years; 50.8% males), replied to a questionnaire with their food preferences regarding taste (salty, sweet, bitter, sour) and consistency (liquid, solid, pasty) for a dialysis snack. Most patients preferred a food product with a solid consistency (90%) and a salty flavor (81.4%). Second, three muffin formulations of fine herbs were developed; one enriched with whey protein concentrate (WPC), a second with textured soy protein (TSP) and a third standard formulation without protein for comparison with the protein-enriched muffins, for which the chemical and nutritional compositions were analyzed. In the third step, 60 patients on HD (61 ± 15 years; 53% males) were enrolled in a sensory analysis by applying a 9-point structured hedonic scale, ranging from “extremely liked” (score 9) to “extremely disliked” (score 1).

Results
When compared with the standard formulation, the formulations enriched with WPC and TSP protein had a significantly higher amount of protein/serving (Standard: 5.9 ± 0.3 g vs WPC: 14.5 ± 0.9 g and TSP 10.8 ± 0.7 g; P < 0.05) but a lower amount of carbohydrate (Standard: 13.1 ± 2.2 g vs WPC: 5.6 ± 0.8 g and TSP 6.0 ± 1.2 g vs; P < 0.05). The mineral content/serving of the protein-enriched muffins was low in phosphorus (50 mg) and sodium (180 mg). The potassium content/serving was moderate for the WPC muffin (225.2 mg) and low for the TSP muffin (107.9 mg). The acceptability index (AI) for the enriched protein muffins was higher than 70% and similar to the standard formulation.

Conclusion
The muffins with fine herbs and enriched with protein were well-accepted by all patients and appropriate to serve as dialysis snacks for HD patients.
Detecting Modern Slavery on Cannabis Farms: The Challenges of Evidence
Authors: Ramiz Adam , Rock Paul , Strang Heather 
Published: August 2020

Abstract
Research Question
To what extent could police identify victims of modern slavery among growers arrested on cannabis farms as suspects under drug laws, and what challenges of evidence would have to be met to separate offending from victimisation?

Data
A purposive sample of criminal history data of all Vietnamese nationals arrested for cannabis cultivation offences in Surrey/Sussex in the 3 years to 2017 (N = 19) was identified and collected. Three ‘cannabis farm’ cases from the period 2014–2017 were analysed to produce key information about growers, including their nationality, criminal history and possible status as modern slavery victims. The case records and interviews provide key information about the extent to which growers on farms were treated as slaves under the 2015 Modern Slavery Act.

Methods
Semi-structured interviews were conducted with the three arrested growers to explore their lived experiences of recruitment and labour on the farms. Arresting police officers were also interviewed to explore how they frame the problem of cannabis cultivation and make decisions about their role in confronting it. Interview transcripts were prepared for analytic purposes. All interviewees were informed that the research was focused on the management of the policing of cannabis farms alone and full anonymity was assured.

Findings
Five of the 19 Vietnamese nationals had previous criminal disposals. Of the remaining 14 individuals, five had no record and nine had various charges, but the prosecutions had not reached court.
Of the three cases examined in depth, the arrested growers provided stories consistent with their having been trafficked and subjected to ‘debt bondage’. They described precarious journeys before being forced to work on UK farms. All three had been exposed to threats of violence or death for themselves and/or their families, should they attempt escape. Varying levels of mental and physical hardship were evidenced. There were a priori reasons to conclude that they were eligible to be considered modern slavery victims. When arrested, however, none had pleaded victimisation. Police officers demonstrated an ignorance of related legislation and varying levels of awareness of the possibility of modern slavery. They responded to the first impression made by the grower as a person culpable under drugs laws. Even where officers had concerns about modern slavery, no appropriate crime was recorded, and no formalised investigation followed.

Conclusions
Given reluctance or inability to frame the police response to cannabis farms under modern anti-slavery legislation, policing agencies should consider adopting more detailed practice guidelines to officers on how to react to the complex challenges involved, including the investigative opportunities that may help unearth modern slavery on cannabis farms through greater encouragement of victim accounts.
Survival and Health Care Use After Deep Brain Stimulation for Parkinson’s Disease
Authors: Crispo James A.G. , Lam Melody , Le Britney , Shariff Salimah Z. , Ansell Dominique R. , Squarzolo Melanie , Ouellette Danielle , Thibault Dylan P. , Marras Connie , Willis Allison W. , Seitz Dallas 
Published: August 2020

ABSTRACT:Objectives:To compare long-term survival of Parkinson’s disease (PD) patients with deep brain stimulation (DBS) to matched controls, and examine whether DBS was associated with differences in injurious falls, long-term care, and home care.Methods:Using administrative health data (Ontario, Canada), we examined DBS outcomes within a cohort of individuals diagnosed with PD between 1997 and 2012. Patients receiving DBS were matched with non-DBS controls by age, sex, PD diagnosis date, time with PD, and a propensity score. Survival between groups was compared using the log-rank test and marginal Cox proportional hazards regression. Cumulative incidence function curves and marginal subdistribution hazard models were used to assess effects of DBS on falls, long-term care admission, and home care use, with death as a competing risk.Results:There were 260 DBS recipients matched with 551 controls. Patients undergoing DBS did not experience a significant survival advantage compared to controls (log-rank test p = 0.50; HR: 0.89, 95% CI: 0.65–1.22). Among patients <65 years of age, DBS recipients had a significantly reduced risk of death (HR: 0.49, 95% CI: 0.28–0.84). Patients receiving DBS were more likely than controls to receive care for falls (HR: 1.56, 95% CI: 1.19–2.05) and home care (HR: 1.59, 95% CI: 1.32–1.90), while long-term care admission was similar between groups.Conclusions:Receiving DBS may increase survival for younger PD patients who undergo DBS. Future studies should examine whether survival benefits may be attributed to effects on PD or the absence of comorbidities that influence mortality.
Validation of an algorithm for semiautomated surveillance to detect deep surgical site infections after primary total hip or knee arthroplasty—A multicenter study
Authors: Verberk Janneke D. M. , van Rooden Stephanie M. , Koek Mayke B. G. , Hetem David J. , Smilde Annelies E. , Bril Wendy S. , Streefkerk Roel H. R. A. , Hopmans Titia E. M. , Bonten Marc J. M. , de Greeff Sabine C. , van Mourik Maaike S. M. 
Published: August 2020

AbstractObjective:Surveillance of healthcare-associated infections is often performed by manual chart review. Semiautomated surveillance may substantially reduce workload and subjective data interpretation. We assessed the validity of a previously published algorithm for semiautomated surveillance of deep surgical site infections (SSIs) after total hip arthroplasty (THA) or total knee arthroplasty (TKA) in Dutch hospitals. In addition, we explored the ability of a hospital to automatically select the patients under surveillance.Design:Multicenter retrospective cohort study.Methods:Hospitals identified patients who underwent THA or TKA either by procedure codes or by conventional surveillance. For these patients, routine care data regarding microbiology results, antibiotics, (re)admissions, and surgeries within 120 days following THA or TKA were extracted from electronic health records. Patient selection was compared with conventional surveillance and patients were retrospectively classified as low or high probability of having developed deep SSI by the algorithm. Sensitivity, positive predictive value (PPV), and workload reduction were calculated and compared to conventional surveillance.Results:Of 9,554 extracted THA and TKA surgeries, 1,175 (12.3%) were revisions, and 8,378 primary surgeries remained for algorithm validation (95 deep SSIs, 1.1%). Sensitivity ranged from 93.6% to 100% and PPV ranged from 55.8% to 72.2%. Workload was reduced by ≥98%. Also, 2 SSIs (2.1%) missed by the algorithm were explained by flaws in data selection.Conclusions:This algorithm reliably detects patients with a high probability of having developed deep SSI after THA or TKA in Dutch hospitals. Our results provide essential information for successful implementation of semiautomated surveillance for deep SSIs after THA or TKA.
Dietary lipid and n-3 long-chain PUFA levels impact growth performance and lipid metabolism of juvenile mud crab, Scylla paramamosain
Authors: Wang Xuexi , Jin Min , Cheng Xin , Luo Jiaxiang , Jiao Lefei , Betancor Mónica B. , Tocher Douglas R. , Zhou Qicun 
Published: August 2020

AbstractAn 8-week feeding trial was conducted to evaluate the effects of dietary n-3 LC-PUFA levels on growth performance, tissue fatty acid profiles and relative expression of genes involved in the lipid metabolism of mud crab (Scylla paramamosain). Ten isonitrogenous diets were formulated to contain five n-3 LC-PUFA levels at 7 and 12 % dietary lipid levels. The highest weight gain and specific growth rate were observed in crabs fed the diets with 19·8 and 13·2 mg/g n-3 LC-PUFA at 7 and 12 % lipid, respectively. Moisture and lipid contents in hepatopancreas and muscle were significantly influenced by dietary n-3 LC-PUFA at the two lipid levels. The DHA, EPA, n-3 LC-PUFA contents and n-3:n-6 PUFA ratio in hepatopancreas and muscle significantly increased as dietary n-3 LC-PUFA levels increased at both lipid levels. The expression levels of -6 fatty acyl desaturase and acyl-CoA oxidase in hepatopancreas increased significantly, and expression levels of fatty acid synthase, carnitine palmitoyltransferase I and hormone-sensitive TAG lipase were down-regulated, with increased dietary n-3 LC-PUFA regardless of lipid level. Based on weight gain, n-3 LC-PUFA requirements of S. paramamosain were estimated to be 20·1 and 12·7 mg/g of diet at 7 and 12 % dietary lipid, respectively. Overall, dietary lipid level influenced lipid metabolism, and purified, high-lipid diets rich in palmitic acid reduced the n-3 LC-PUFA requirement of juvenile mud crab.
Reading minds in motion: Mouse tracking reveals transposed-character effects in Chinese compound word recognition
Authors: Lin Yu-Cheng , Lin Pei-Ying 
Published: August 2020

AbstractThis study investigated the development of character transposition effects during Chinese compound word recognition via computer mouse movements instead of the conventional key presses. Empirical evidence to reveal the impacts of vocabulary knowledge, grade level, and whole word frequency on Chinese transposed-character effect is lacking. In the present study, we measured the transposed-character effect in two groups of Taiwanese children (second and fourth graders) in a mouse-tracking lexical-decision task including nonwords derived from real words by transposing two characters (e.g., “習學” from “學習” [learning]) and control nonwords in which two characters are replaced (e.g., “以修”). Our results indicate that participants showed longer mouse movement times and larger spatial attraction in recognizing transposed-character nonwords than in replaced-character nonwords, suggesting that the dominant role of whole-word representation in processing Chinese compound words. Our results also further demonstrate that how the degree of character transposition was affected by vocabulary knowledge, grade level, and word frequency.
Not our ‘Dunedin sound’: Responses to the historicisation of Dunedin popular music
Authors: Wilson Oli , Holland Michael 
Published: August 2020

AbstractThe music that was produced in Dunedin, New Zealand, during the 1980's occupies a unique place in the global indie music canon. In writing about this supposed ‘Dunedin sound,' critics and scholars alike have fixated on the city's remoteness: it is believed to be distant from metropolitan centres of music industry power and influence, and consequently supported a subversive and democratised local music scene. This article explores the implications of the ongoing historicisation of Dunedin's popular music scene along these lines, and highlights the ways in which the valorisation of the city’s musical heritage obstructs problematic power dynamics that impact the way young musicians in the city express place and musical identity. Our research applies an embedded participatory ethnography to unpack the ideological positions occupied by contemporary local musicians, and to critique factions within the contemporary musical scene in the city.
Pie laika … Now is the time. The singing revolution on Latvian radio and television
Authors: Gronow Pekka , Daugavietis Jānis 
Published: August 2020

AbstractIn the Soviet Union, song competitions had an important role in presenting new artists and songs. TheMikrofona aptaujacontest of Latvian radio (1968–1994) was the main forum for new Latvian pop music. It had a reputation for expressing nationalist feelings within the limits of Soviet censorship. In 1988, with the rise of new political movements in the Soviet Union, the competition became a venue for the Latvian independence movement. The winning song of 1988 was a demand for ‘freedom to the fatherland’. The competition also played a part in the rehabilitation of pre-war popular music which had been forbidden in Soviet Latvia. The paper discusses the role of journalists, politicians and songwriters in this process. After the privatisation of the economy, the song competition was taken over by private entrepreneurs, as public interest in political songs waned.