bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of pancreatic solid pseudopapillary neoplasms using cell‐blocks and immunohistochemical evaluation of endoscopic ultrasound‐guided fine needle aspiration biopsy specimens
Authors: Ardengh José Celso , Lopes César Vivian , Venco Filadélfio Euclides , Machado Marcel Autran 
Published: August 2020

AbstractIntroductionPreoperative diagnostic imaging of pancreatic solid pseudopapillary neoplasms (SPNs) is challenging. A few studies have investigated the role of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) for the diagnosis of SPN. We investigated the diagnostic yield of cell‐blocks and immunohistochemistry (IHC) for SPN using EUS‐FNA specimens without cytological evaluation.Patients and methodsWe retrospectively analysed the histopathology records of patients with suspected SPN, who underwent EUS‐FNA biopsy between January 1997 and January 2020. Diagnosis based on cell‐blocks (haematoxylin‐eosin staining with complementary IHC) was compared with the definitive surgical diagnosis.ResultsThis study included 25 patients (24 were women). Patients' mean age was 33.7 years (range 12‐78 years). The most common symptom was abdominal pain. SPN was an incidental finding in 52% of the patients. The mean lesion size was 4.3 cm (range 1.2‐11.4 cm), and the most common endosonographic features included solid‐cystic (56%) or solid (40%) tumours. Final diagnoses included SPNs (n = 23) and non‐functioning neuroendocrine tumours (n = 2). The overall accuracy of EUS‐FNA was 80%. Tumour cells showed immunopositivity for β‐catenin, CD10, CD99 and progesterone receptor (PR) in 93.7%, 87.5%, 83.3% and 66.6% of patients, respectively. No SPN showed immunopositivity for chromogranin A.ConclusionsIntention‐to‐diagnose analysis showed that the diagnostic accuracy of EUS‐FNA for SPNs using cell blocks and complementary IHC without cytological evaluation was fairly good. Evaluation of β‐catenin, CD 10, CD99 and PR expression must be included in the IHC panel for diagnostic confirmation of SPNs using EUS‐FNA biopsy specimens.
Combination therapy of oral propranolol and combined Nd:YAG/pulsed dye laser therapy in infantile hemangiomas: a retrospective analysis of 48 treated hemangiomas in 30 children
Authors: Hartmann Franziska , Lockmann Anike , Himpel Okko , Kühnle Ingrid , Hensen Janina , Schön Michael P. , Thoms Kai‐Martin 
Published: August 2020

SummaryBackground and aimsInfantile hemangiomas can be successfully treated by both systemic propranolol and neodymium:YAG (Nd:YAG)‐dye laser combination therapy. In this retrospective study, the efficacy and safety of sequential and parallel therapy of complicated hemangiomas treated with both methods were evaluated.Patients and methods30 children with 48 complicated hemangiomas were treated with propranolol and Nd:YAG‐dye laser combination therapy. Using photo comparison, the percentage remission rate was evaluated by three investigators on a four‐step scale (I: 0–25 %, II: 26–50 %, III: 51–75 % and IV: 76–100 %).ResultsEleven children received propranolol and laser therapy in parallel (A), twelve children received laser therapy after propranolol (B) and seven children received propranolol after laser therapy (C). Due to emigration abroad, one child was lost to follow‐up. A strong improvement (IV) was observed in 23/29 (79.3 %) of all treated children (A: 90.9 %, B 75 %, C 66.7 %). The mean duration of propranolol therapy in all children was 8.6 months (A: 8.9 months, B: 8.2 months, C: 8.9 months). On average, 2.33 laser treatments were performed per hemangioma (A: 1.95, B: 3.2, C: 1.91). Serious side effects caused by propranolol and laser therapy were not observed.ConclusionsPropranolol and Nd:YAG‐dye laser combination therapy can be used sequentially or in parallel safely and effectively. They complement each other in a meaningful manner.
Subcontracting New Product Development Projects: The Role of Competition and Commitment
Authors: Gernert Andreas , Heese H. Sebastian , Wuttke David A. 
Published: August 2020

ABSTRACTShould a firm, which seeks to subcontract a new product development project, leverage competition among potential suppliers and ask all of them to engage in research and development in parallel? Or should it first invite offers and commit to the supplier with the best offer, before only this supplier engages in development? Building on analytical literature on both formats, we apply game theory to answer these questions. We identify Bayesian Nash equilibrium strategies and characterize advantages of both formats. We find that having multiple suppliers engage in new product development in parallel is favored only if enough suppliers can be attracted, which is the case when development uncertainty and learning benefits are high. The participation decision also depends on the specific structure of the project's development costs. If administrative overhead and material costs are substantial, while engaging in development and exerting effort is relatively cheap but does not offer many learning opportunities, the number of suppliers who would be willing to engage in parallel development is limited. First inviting offers and selecting the best supplier to exclusively engage in new product development then becomes more attractive for the buyer. We discuss further implications and characterize environments that may foster more innovativeness in this context.
3D ultrasound to quantify lateral hip displacement in children with cerebral palsy: a validation study
Authors: Kay Rebecca H , Noble Jonathan J , Johnston Liam , Keevil Stephen F , Kokkinakis Michail , Reed Daniel , Gough Martin , Shortland Adam P 
Published: August 2020

AimTo assess the validity of a new index, lateral head coverage (LHC), for describing hip dysplasia in a population of children with cerebral palsy (CP).MethodLHC is derived from 3D ultrasound assessment. Twenty‐two children (15 males, seven females; age 4–15y) with CP undergoing routine hip surveillance were recruited prospectively for the study. Each participant had both a planar radiograph acquired as part of their routine care and a 3D ultrasound assessment within 2 months. Reimer's migration percentage (RMP) and LHC were measured by the same assessor, and the correlation between them calculated using Pearson’s correlation coefficient. The repeatability of LHC was investigated with three assessors, analysing each of 10 images three times. Inter‐ and intra‐assessor variation was quantified using intraclass correlation coefficients.ResultsLHC was strongly correlated with RMP (Spearman's rank correlation coefficient=−0.86, p<0.001). LHC had similar inter‐assessor reliability to that reported for RMP (intraclass correlation coefficient=0.97 and intra‐assessor intraclass correlation coefficient=0.98).InterpretationThis is an initial validation of the use of 3D ultrasound in monitoring hip development in children with CP. LHC is comparable with RMP in estimating hip dysplasia with similar levels of reliability that are reported for RMP.
Evaluation of the diagnostic performance of the creatinine‐based Chronic Kidney Disease Epidemiology Collaboration equation in people with diabetes: A systematic review
Authors: Zafari N. , Churilov L. , Wong L. Y.‐L. , Lotfaliany M. , Hachem M. , Kiburg K. V. , Kong L. , Torkamani N. , Baxter H. , MacIsaac R. J. , Ekinci E. I. 
Published: August 2020

AbstractAimsGFR estimated with the creatinine‐based Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPICr) equation is used to screen for diabetic kidney disease and assess its severity. We systematically reviewed the process and outcome of evaluating CKD‐EPICr in estimating point GFR or GFR decline over time in adults with type 1 or type 2 diabetes.MethodsIn this systematic review, MEDLINE, Embase and Cochrane Central Register of Controlled Trials were searched up to August 2019. Observational studies comparing CKD‐EPICr with measured GFR (mGFR) in adults with diabetes were included. Studies on people with kidney transplant, non‐diabetes related kidney disease, pregnancy, potential kidney donors, and those with critical or other systematic illnesses were excluded. Two independent reviewers extracted data from published papers and disagreements were resolved by consensus. Risk‐of‐bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies‐2 tool. (PROSPERO registration number: CRD42018108776).ResultsFrom the 2820 records identified, 29 studies (14 704 participants) were included. All studies were at risk of bias. Bias (eight different forms) ranged from −26 to 35 ml min−1 1.73 m−2; precision (five different forms) ranged between 9 and 63 ml min−1 1.73 m−2; accuracy (five different forms) ranged between 16% and 96%; the correlation coefficient between CKD‐EPICr and mGFR (four different forms) ranged between 0.38 and 0.86; and the reduced major axis regression slope ranged between 0.8 and 1.8.ConclusionsQualitative synthesis of data suggested CKD‐EPICr was inaccurate in estimating point GFR or GFR decline over time. Furthermore, a lack of consistency in the methods and processes of evaluating the diagnostic performance of CKD‐EPICr limits reliable quantitative assessment. The equation needs to be improved in adults with diabetes.
Multimodality imaging of left ventricular apical pseudoaneurysm after apical approach transcatheter aortic valve replacement
Authors: Ansari‐Gilani Kianoush , Sareyyupoglu Basar 
Published: August 2020

AbstractLeft ventricular pseudoaneurysm formation is a rare complication of transapical approach transcatheter aortic valve replacement. It can cause chest pain and shortness of breath or remain asymptomatic. Mortality rate is high, and therefore, timely diagnosis and management are essential. Different imaging modalities can provide anatomic or functional information and are essential for the primary diagnosis or during follow‐up.
Right ventricular dysfunction in stress cardiomyopathy: The prognostic value of fractional area change
Authors: Subramanian Muthiah , Ahamed Hisham , Reddy Chirag , Mathew Navin , Chandrasekhar Rajiv 
Published: August 2020

AbstractBackgroundThere are limited data on the impact of right ventricular dysfunction (RVD) on the clinical outcomes in patients with stress cardiomyopathy (SC). The purpose of this study was to evaluate the impact of RVD on outcomes and to characterize the prognostic value of RV fractional area change (FAC).MethodsThis study retrospectively analyzed data from 111 consecutive patients with SC. The primary endpoint, major cardiac events (MCE), was a composite of 30‐day mortality, cardiogenic shock, life threatening arrhythmias, and stroke. Regression analysis was used to identify independent predictors of short (30 days)‐ and long‐term MCE.ResultsAmong the 111 patients (80.2% females, mean age 45.8 ± 11.5 years), RVD was present in 17(15.3%) patients. MCE occurred in 18(16.2%) and 22(19.8%) patients at 30 days and during long‐term follow‐up, respectively. RVD was an independent predictor of short (HR 1.88(1.21–15.67), P = .036)‐ and long (HR 1.65(1.11–9.67), P = .016)‐term MCE. Compared with tricuspid annular plane systolic excursion < 15 mm (TAPSE) (sens 72.2%, spec 94.1%, AUC 0.75) and tricuspid annulus pulsed TDI‐derived peak systolic velocity (S′) < 9.5 cm/s (sens 67.2%, spec 94.5%, AUC 0.72), RV FAC < 30% (sens 89.1%, spec 100%, AUC 0.92) had the highest accuracy and discriminative ability to predict MCE. Furthermore, RV FAC < 30% was a significant predictor of recurrence (29.4% vs 2.1%, P = .002) and delayed recovery time (21.4 ± 6.8 vs 8.5 ± 4.3 days, P < .001).ConclusionsThe presence of RVD in stress cardiomyopathy identifies patients at higher risk of mortality, complications, delayed recovery, and recurrence. Compared with other indices, RV FAC has the highest prognostic ability to predict these outcomes.
Fragment reattachment after complicated crown‐root fractures of anterior teeth: A systematic review
Authors: Khandelwal Priyal , Srinivasan Siddharth , Arul Buvaneshwari , Natanasabapathy Velmurugan 
Published: August 2020

AbstractBackground/AimFragment reattachment is a procedure that can immediately restore form and function in crown‐root fracture cases and is considered a minimally invasive and cost‐effective treatment option. The aim of this systematic review was to analyze the methods used and the outcome of fragment reattachment for complicated crown‐root fractures of anterior teeth.Materials and MethodsFive electronic databases (PubMed, Web of Science, Embase, Scopus, and Google Scholar) were searched for English language articles regarding fragment reattachment after complicated crown‐root fractures of anterior teeth.ResultsTwelve case reports and two case series were selected for this review after applying the inclusion and exclusion criteria. In eleven articles, the fracture line was exposed prior to reattachment. Root canal treatment was performed in all cases except one, where conservative pulp treatment was done prior to reattachment. A post was used as part of the restoration in 85% of the cases. Additional fragment preparation was done in 42% of the cases in the form of beveling and groove formation. Adhesive strategies used to reattach the coronal fragments were total‐etch, self‐etch, or self‐cure adhesive. Intermediate materials used for reattachment were resin cement, glass‐ionomer cement, composite and self‐adhesive cement. Treatment outcomes were favorable in all the included articles and the follow‐up period ranged from three months to seven years.ConclusionFragment reattachment after complicated crown‐root fractures of anterior teeth can be considered as a viable treatment option if the clinical conditions are favorable.
Song learning by prairie warblers: When, where, and from whom
Authors: Byers Bruce E. , Akresh Michael E. , King David I. 
Published: August 2020

AbstractSongbirds of many species acquire their songs by imitating the songs of conspecific singers. Conclusive evidence of such imitation comes from controlled laboratory studies, but such studies do not reveal when and where songbirds learn their songs under natural conditions. To determine the timing and location of song learning in a population of prairie warblers, we compared the songs of yearling prairie warblers of known hatching location to the songs of other birds in the yearlings' natal and first breeding areas. The comparisons yielded a likely model song (and model singer) for each of the song types used by the focal yearlings. We supplemented our findings from the song comparisons with inferences drawn from an analysis of local geographic variation in songs. This analysis revealed that shared song types showed no tendency to be geographically clustered within the study area. Taken together, our data suggest that prairie warblers learn their songs during the hatch year, at locations somewhat distant (mean distance 1,437 m) from their natal site, most likely as birds wander about during the post‐fledging period.
Changing climate reallocates the carbon debt of frequent‐fire forests
Authors: Goodwin Marissa J. , North Malcolm P. , Zald Harold S. J. , Hurteau Matthew D. 
Published: August 2020

AbstractOngoing climate change will alter the carbon carrying capacity of forests as they adjust to climatic extremes and changing disturbance regimes. In frequent‐fire forests, increasing drought frequency and severity are already causing widespread tree mortality events, which can exacerbate the carbon debt that has developed as a result of fire exclusion. Forest management techniques that reduce tree density and surface fuels decrease the risk of high‐severity wildfire and may also limit drought‐induced mortality by reducing competition. We used a long‐term thinning and burning experiment in a mixed‐conifer forest to investigate the effects of the 2012–2015 California drought on forest carbon dynamics in each treatment, including the carbon emissions from a second‐entry prescribed fire that followed the drought. We assessed differences in carbon stability and tree survival across treatments, expecting that both carbon stability and survival probability would increase with increasing treatment intensity (decreasing basal area). Additionally, we analyzed the effects of drought‐ mortality on second‐entry burn emissions and compared emissions for the first‐ and second‐entry burns. We found a non‐linear relationship between treatment intensity and carbon stability, which was in part driven by varying relationships between individual tree growing space and survival across treatments. Drought mortality increased dead tree and surface fuel carbon in all treatments, which contributed to higher second‐entry burn emissions for two of the three burn treatments when compared to the first burn. Our findings suggest that restoration treatments will not serve as a panacea for ongoing climate change and that the carbon debt of these forests will become increasingly unstable as the carbon carrying capacity adjusts to severe drought events. Managing the carbon debt with prescribed fire will help reduce the risk of additional mortality from wildfire, but at an increasing carbon cost for forest management.
Longitudinal Impact of Parent Factors in Adolescents With Migraine and Tension‐Type Headache
Authors: Law Emily F. , Blume Heidi , Palermo Tonya M. 
Published: August 2020

ObjectiveTo examine longitudinal associations between parent factors (parent headache frequency and disability, protective parenting behaviors, parent catastrophizing) with adolescent headache‐related disability and headache frequency over 6 months.BackgroundTheoretical models propose bidirectional, longitudinal relationships between parent factors and adolescent headache. Few studies have examined this using prospective study designs.Design and MethodsParticipants were a cohort of 239 youth ages 11‐17 years with recurrent migraine (with and without aura; chronic migraine) or tension‐type headache (episodic and chronic) and their parents recruited from a pediatric neurology clinic and the community who completed assessments at baseline and 6‐month follow‐up.ResultsAfter controlling for demographic and clinical covariates, we found that every point increase in baseline protective parenting behavior corresponded with a 2.19‐point increase in adolescent headache frequency at follow‐up (P = .026, 95% CI [0.27, 4.10]). Similarly, every point increase in baseline parent catastrophizing corresponded with a 0.93‐point increase in adolescent headache‐related disability (P = .029, 95% CI [0.09, 1.77]) and a .13‐point increase in adolescent headache frequency (P = .042, 95% CI [0.01, 0.25]) at follow‐up. We also found support for the reverse association, where every point increase in baseline adolescent headache‐related disability predicted a 0.03‐point increase in parent catastrophizing (P = .016, 95% CI [0.01, 0.05]) and a 0.02‐point increase in protective parenting behavior (P = .009, 95% CI [0.01, 0.03]) at follow‐up. The remaining bidirectional, longitudinal associations tested between parent factors and adolescent headache were not statistically significant.ConclusionFindings suggest that family‐based psychological interventions targeting modifiable adolescent and parent factors may lead to improvements in adolescent headache‐related disability and reductions in adolescent headache frequency.
Does workplace violence, empathy, and communication influence occupational stress among mental health nurses?
Authors: Yao Xiuyu , Shao Jing , Wang Lina , Zhang Jing , Zhang Chang , Lin Yujie 
Published: August 2020

AbstractWorkplace violence is a major cause of occupational stress among mental health nurses, particularly those working in acute care. This study investigated the occurrence of occupational stress among mental health nurses in psychiatric hospitals and explored whether workplace violence, empathy, and communication skills influenced occupational stress levels in this population. A socio‐demographic questionnaire and the Chinese Nursing Work Stress Scale, Workplace Violence Scale, Jefferson Scale of Empathy – Health Professions version, and Nurses’ Clinic Communication Competence Scale were administered to 539 mental health nurses from three top‐grade tertiary research hospitals in the Beijing–Tianjin–Hebei region. The analysis revealed a high level of job stress (3.06 ± 0.69) and a moderate prevalence of workplace violence (6.21 ± 2.94) existed among participants when compared with among other nurses. Meanwhile, participants’ empathy (114.78 ± 15.99) and communication (4.31 ± 0.60) abilities were similar to or higher than those of other nursing populations. Mental health nurses with varying years of practice experience distinct levels of job stress. A linear regression analysis revealed that, while practice years (β = 0.104;P < 0.05) and workplace violence (β = 0.264;P < 0.01) aggravated occupational stress levels, empathy (β = −0.147;P < 0.01) facilitated reductions in stress. Results suggest that reducing workplace violence and improving empathy in therapeutic relationships can limit the pervasiveness of occupational stress among mental health nurses. Having both psychological support and organizational support after a violent incident is essential, and the importance of professional education should be stressed.
A Case of Acardiac Anomaly in the Cynomolgus Monkey (Macaca fascicularis): A Complication of Monozygotic Monochorial Twinning
Authors: Hein P.R. , van Groeninghen J.C. , Puts J.J.G. 
Published: August 2020

A case of acardius acephalus in a Macaca fascicularis is reported. This congenital anomaly occurs only in multiple‐birth gestations (most commonly monozygotic twins). Artcry‐to‐artery and vein‐to‐vein anastomoses appear to be a constant feature. This condition is very rare in man and probably even more so in monkeys.Classification and theories on etiology are discussed.
Urinary enzyme concentrations in the owl monkey (Aotus nancymae)
Authors: Weller R.E. , Málaga C.A. , Buschbom R.L. , Ragan H.A. 
Published: August 2020

The activity of three urinary enzymes, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and N‐acetyl‐β‐D‐glucosaminidase (NAG), was evaluated in 71 adult owl monkeys. Fifty‐six animals had normal renal function, while 15 had evidence of renal dysfunction.Urinary enzyme: urinary creatinine ratios (UE:UCr) were also determined. The activity for NAG was similar to that of other species, while ALP and AST were higher. Regression analyses revealed that urinary enzymes and UE:UCr were significantly correlated (P ≤ 0.0001) with indices of renal damage and could identify active renal disease.
A comparison of morphometry from captive and free‐ranging Macaca mulatta
Authors: Gore Mauvis A. 
Published: August 2020

The paper addresses the effect of captivity on body size in Macaca mulatta, comparing a captive with the free‐ranging population from which it was derived. The captive population, which was housed socially, was smaller in most linear measures and in body mass, particularly in young up to 13 month old animals. Nutritional differences in the diet may be at least partially responsible; the captive population was fed a lower level of total protein. Measurements for captive individuals < 24 hours to 36 months old are discussed in detail.
Primary renal hemangiosarcoma in a moustached tamarin
Authors: Gozalo Alfonso , Chavera Alfonso , Dagle Gerald E. , Montoya Enrique , Weller Richard E. 
Published: August 2020

A wild‐caught adult female Saguinus mystax died after 54 months in captivity. At necropsy, a small reddish zone in the renal cortex of one kidney was shown histologically to be a hemangiosarcoma.