bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case of Van-Wyk Grumbach syndrome
Authors: Vasudevan Vishnu , Viswanath Arun , Misgar Riaz Ahmad 
Published: November 2020

Background: Hypothyroidism in childhood typically leads to delayed puberty, rarely can it cause precocious puberty - this latter complex is eponymously known as Van-Wyk Grumbach syndrome.
Case description: We report a case of a seven and a half-year-old girl who was referred with vaginal bleeding after a diagnosis of primary hypothyroidism and starting treatment with levothyroxine. This case report illustrates the typical features of this rare syndrome for primarily educational purposes. Many case reports of Van Wyk Grumbach syndrome have been published in world literature over the past seven decades after the initial description. Though the features of this syndrome are fairly well described previously, the understanding of pathophysiological mechanisms is speculative and still evolving.
Clinical relevance: Further widespread awareness of the complex will encourage primary physicians and pediatricians to counsel the family of a child before starting treatment for hypothyroidism which will help avoid unnecessary worry and more importantly inadvertent procedures or intervention.
High Flow Nasal Cannula Oxygenation
Authors: Shah Tajamul Hussain , Mantoo Suhail , Jan Rafi Ahmad 
Published: November 2020

High Flow Nasal Cannula Oxygenation
The current pandemic of COVID-19 caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tested the healthcare infrastructure throughout the globe at all possible levels. Early reports suggest about 20% of patients infected with SARS-CoV-2 require hospitalization and 5-8% require admission to intensive care unit (ICU) due to severe disease.Supplementation of oxygen provided by various conventional oxygen therapy (COT) devices (like nasal prongs, face mask, venture mask or non-rebreather mask) may not be sufficient in cases of worsening respiratory failure. One form of escalating respiratory support in such patients is a high flow nasal oxygenation device. High flow nasal cannula oxygenation (HFNC) is a form of non invasive respiratory support. It acts as a bridge between low flow devices and non invasive ventilation and may reduce the need for intubation.
Intracisternal papaverine toxicity in anterior circulation aneurysm clipping surgery
Authors: Al-Sharshahi Zahraa F. , Hoz Samer S. , Almurayati Mustafa E. , Kareem Zahraa M. , Ameen Zahraa 
Published: November 2020

Introduction. Cerebral vasospasm is a major cause of mortality in patients with subarachnoid haemorrhage. Irrigation of intracisternal papaverine has been adopted as a strategy to reduce the incidence of aneurysm-surgery-associated vasospasm.
Aim. The aim of this literature review is to summarize the reported complications associated with intracisternal papaverine administration.
Patients and Methods. We searched the following databases: PubMed, Google Scholar, Cochrane Library, Clinical Key, Embase, Emerald, Health Business Elite, MEDLINE at OVID, EBM Reviews and Research Gate. The following keywords were used: Intracisternal papaverine, topical papaverine, direct papaverine, a vasodilator for aneurysm surgery, papaverine in aneurysm clipping, papaverine complications and papaverine side effects. The search criteria included all articles published between 1980-2019, in the English language.
Results. Our search yielded a total of 19 articles describing 43 cases. The most common reported complication was ipsilateral oculomotor nerve palsy. Other local complications included: Bilateral oculomotor nerve palsy, ipsilateral facial nerve palsy, and monocular blindness. Although less common, reports pointing to papaverine systemic toxicity did exist. Examples of such complications included: Profound hypotension, bradycardia, hypertension and tachycardia, hyperthermia and metabolic acidosis, cardiac arrest and even death.
Conclusion. Intracisternal papaverine irrigation is an effective strategy in reducing peri-operative vasospasm associated with aneurysm surgery. Although uncommon, both local and systemic side effects have been linked to papaverine use, calling for careful dosing and close monitoring to enhance its safety profile.
The Idiopathic Hypertrophic Spinal Pachymeningitis
Authors: SINGH SURJEET , STUTI KUMARI  , ABHIJEET SACHAN  , SATISH CHANDRA VERMA  
Published: November 2020

Idiopathic hypertrophic spinal pachymeningitis (IHSP) is a rare inflammatory condition characterized by chronic inflammatory hypertrophy of the dura mater. It can involve the entire spine. However, most cases are reported in the cervical and thoracic spine. It can progress from local pain to radiculopathy and eventually develop myelopathy. The aetiology of IHSP is not known. However, it has been suggested to be associated with many diseases. Here we report a case of IHSP in 21-year-old female who presented with paraplegia. The diagnosis was made on MRI Spine and histopathological examination. It was treated with surgical decompression, steroid therapy and patient improved gradually.
Measuring daily functioning in older persons using a frailty index: a cohort study based on routine primary care data
Authors: Ravensbergen Willeke M , Blom Jeanet W , Evers Andrea WM , Numans Mattijs E , de Waal Margot WM , Gussekloo Jacobijn 
Published: November 2020

BackgroundElectronic health records (EHRs) are increasingly used for research; however, multicomponent outcome measures such as daily functioning cannot yet be readily extracted.AimTo evaluate whether an electronic frailty index based on routine primary care data can be used as a measure for daily functioning in research with community-dwelling older persons (aged ≥75 years).Design and settingCohort study among participants of the Integrated Systemic Care for Older People (ISCOPE) trial (11 476 eligible; 7285 in observational cohort; 3141 in trial; over-representation of frail people).MethodAt baseline (T0) and after 12 months (T12), daily functioning was measured with the Groningen Activities Restriction Scale (GARS, range 18–72). Electronic frailty index scores (range 0–1) at T0 and T12 were computed from the EHRs. The electronic frailty index (electronic Frailty Index — Utrecht) was tested for responsiveness and compared with the GARS as a gold standard for daily functioning.ResultsIn total, 1390 participants with complete EHR and follow-up data were selected (31.4% male; median age = 81 years, interquartile range = 78–85). The electronic frailty index increased with age, was higher for females, and lower for participants living with a partner. It was responsive after an acute major medical event; however, the correlation between the electronic frailty index and GARS at T0 and over time was limited.ConclusionBecause the electronic frailty index does not reflect daily functioning, further research on new methods to measure daily functioning with routine care data (for example, other proxies) is needed before EHRs can be a useful data source for research with older persons.
Quand l’empereur marie sa fille : la dot de Gisèle, fille de Louis le Pieux et de Judith, en son contexte
Authors: Le Jan Régine 
Published: November 2020

Le mariage de Gisèle, fille de Louis le Pieux et de Judith, avec Évrard, un membre du groupe puissant Unrochide et titulaire d’honores en Frioul au service de Lothaire Ier,
s’inscrit dans le contexte des négociations devant régler la succession impériale, à la fin des années 830. Par son ampleur inhabituelle, son caractère fiscal, sa situation géographique, la dot qui fut accordée à Gisèle révèle les enjeux de la compétition qui s’est jouée à l’échelle de l’empire et dans les régions transfrontalières, entre les années 830 et la fin du ixe siècle. Sa puissance symbolique était le substrat matériel d’un lien créé par le mariage d’Évrard et de la fille de l’empereur. Elle a ensuite été instrumentalisée par de nombreux acteurs : par le couple Évrard – Gisèle qui l’a répartie entre ses fils cadets pour permettre à l’aîné de recevoir l’héritage italien et alémanique, et qui a aussi réussi à fonder sur un de ces fiscs un monastère, confié à l’un des fils, où Gisèle elle-même ferait entretenir la memoria familiale, sur le modèle des reines ; par le groupe unrochide qui n’a pas manqué de s’appuyer sur ces biens en Francie et en Lotharingie pour gagner en puissance ; par Charles le Chauve qui conservait des droits sur ces biens fiscaux, qui les a confisqués, restitués, au gré de ses relations avec Évrard et son groupe. Le devenir des biens, envisagé à l’échelle locale et à l’échelle impériale, montre que le champ symbolique était lui-même évalué, négocié, hiérarchisé, puisque, du vivant d’Évrard, le couple a finalement préféré prendre le risque de perdre tout ou partie de la dot pour gagner en prestige et puissance du côté de Louis ii en Italie. Mais à l’inverse, une fois veuve, Gisèle a choisi de quitter l’Italie, où son fils aîné avait pris la place du père, pour retrouver ses biens dotaux en Francie, au prix de sa soumission, au moins apparente, à son frère et à ses ambitions impériales. L’analyse de la dot permet ainsi, en faisant varier la focale, de réinsérer Gisèle dans le contexte global pour retrouver l’unité de sa personne, tout en laissant place au temps, au déroulement de la vie d’une femme, soumise aux aléas de la politique et aux pressions, mais parfaitement consciente de son statut et sans doute de ses objectifs.
Écrit et administration des églises locales à l’époque carolingienne : l’exemple du diocèse de Liège sous l’épiscopat de Francon (857/858-901)
Authors: Mériaux Charles 
Published: November 2020

L’étude se consacre à trois documents : une collection de cinq lettres formées, des
litterae formatae, adressées à l’évêque Francon de Liège à la fin des années 850 ; un groupe de six lettres adressées à ce même évêque par des clercs irlandais ; une liste de redevances inédites, d’origine liégeoise, dues par une « église-mère » à son évêque autour de 900. Chacun de ces documents témoigne à sa manière de la poursuite des efforts faits pour améliorer l’administration locale du diocèse de Liège depuis les capitulaires des évêques Gerbaud et Walcaud dans le premier tiers du IXe siècle.
Verhaeren et le « tournant social » de Mallarmé
Authors: Dominicy Marc 
Published: November 2020

Tijdens de herfst van 1887, laat Verhaeren vier opeenvolgende artikels in
L’Art Moderne verschijnen in verband met Le Pitre châtié die blijk geven van zijn grondige kennis van de kunst en van de theoretische grondslagen van Mallarmé. Deze uiting vindt plaats tijdens een periode van ongeveer zeven jaren (1885-1891) waarin beide dichters zeer nauwe banden onderhouden. Een doorgedreven analyse van de herformuleringen die Mallarmé doorvoert op verschillende van zijn teksten, waaronder Le Guignon, en van de figurativisaties die de steeds vernieuwende schriftuur van Verhaeren op hetzelfde ogenblik kenmerken, toont aan dat zowel de ene als de andere dichter, op een gelijklopende manier, zich openstellen voor een nieuwe wereld, die een beweging van laïcisering aanvat en gekenmerkt wordt door sociale strijd en anarchistisch verzet. Daarom kan Verhaeren een lectuur van Le Pitre châtié voorstellen die dit sonnet definitief bevrijdt van elke verwijzing naar de parnassiaanse veroordeling van het histrionisme ; op een gelijklopende wijze, vervangt de herziene versie van het einde van Le Guignon de romantische “martelaren” van de eerste versie door overwonnen strijders van de Parijse Commune.
TPA Punakawan: Sarana Meningkatkan Kecerdasan Spiritual Anak Berbasis Kearifan Lokal
Authors: Ridhwan Raden Muhammad , Susilo Muhammad Willian , Bimasakti Tedy Eka , Chandra Rizki , Alantaqi Ajihuddin , Sugito Sugito 
Published: November 2020

Pengabdian kepada masyarakat ini bermula dari permasalahan tidak aktifnya Taman Pendidikan Al Qur’an (TPA) di Masjid At Taqwa, Desa Temuwuh Lor, Kabupaten Sleman yang disebabkan oleh rendahnya minat anak untuk belajar, rendahnya kesadaran orang tua akan pentingnya pendidikan agama bagi anak, dan kurang aktifnya para pengajar. Melihat pentingnya TPA sebagai sarana pengembangan kecerdasan spiritual anak dan pentingnya kesadaran anak akan kearifan lokal dari budaya wayang, maka kami berinisiatif membentuk “TPA PUNAKAWAN” yang bertujuan untuk meningkatkan minat anak dalam belajar agama dan budaya di TPA sehingga dapat meningkatkan kecerdasan spiritual yang berbasis agama dan kearifan lokal. Dengan menggunakan metode pemberdayaan partisipatif yang bermitra dengan takmir masjid dan remaja masjid At Taqwa Temuwuh Lor, pengabdian masyarakat ini berhasil melaksanakan serangkaina kegiatan yang meliputi penyuluhan untuk orang tua santri, pelatihan bagi pengajar TPA, pengajaran di TPA dengan menggunakan modul pembelajaran dan media wayang serta permainan tradisional, melengkapi sarana TPA dengan Pojok Budaya, dan menjaga keberlanjutan program dengan terbentuknya pengurus TPA Punakawan. TPA Punakawan telah berhasil meningkatkan minat belajar anak ke TPA dan meningkatkan pemahaman agama serta kearifan lokal yang ada dalam wayang Punakawan.
Tahap Perencanaan Media Pembelajaran Komik Strip Abah Umis Pada Materi Kausa Materialis Pancasila
Authors: Husen Wan Ridwan , Apriani Arni , Nugraha Fajar 
Published: November 2020

Tulisan ini merupakan langkah kedua setelah melakukan tahap design (Perancangan), yaitu tahap perancangan (design) dari media pembelajaran komik strip yang dibuat, pembahasan dalam tahap perencanaan ini terdapat beberapa tahap diantaranya penyusunan Tes (criterion-test construction) kemudian bagaimana pemilihan Media (media selection) lalu pemilihan Format (format selection) dan desain Awal (initial design). Tujuan dari penelitian “Pengembangan Komik Strip Abah Umis Sebagai Media Pembelajaran Materi Kausa Materilialis Pancasila” ini adalah untuk Mengembangkan komik Strip Abah Umis sebagai media pembelajaran pada materi Kausa Materilialis Pancasila.
Komik strip Abah Umis ini dirancang sebagai media pembelajaran yang diharapkan dapat menumbuhkan kesadaran mahasiswa terhadap pancasila, dengan mengenal bagaimana asal usul Pancasila khusnya maetialis kausa Pancasila maka diharapkan dapat diaplikasikan dalam kehidupan sehari-hari. Penelitian ini menggunakan pendekatan kuantitatif, Metode yang digunakan dalam penelitian ini adalah penelitian dan pengembangan. Model pengembangan dalam media pembelajaran ini menggunakan model pengembangan 4-D (Four D), artikel ini di fokuskan pada tahapan awal yaitu tahap perencanaan untuk model pengembangan media pembelajaran, Subjek penelitian ini yaitu mahasiswa yang mengontrak mata kuliah PKN di UMTAS (Universitas Muhammadiyah Tasikmalaya).
Allah Trinitaris Dalam Refleksi John Zizioulas
Authors: Fu Lan Yap 
Published: November 2020

Abstrak: John Zizioulas merefleksikan kembali doktrin Allah Trinitaris dan mencoba mencari cara-cara baru menolong umat beriman zaman ini menemukan makna ajaran iman ini. Merujuk teologi para Bapa Gereja Kapadokia, Zizioulas mengajukan gambar Allah Trinitaris sebagai Pribadi yang berkomunitas. Pribadi memiliki tiga karakteristik: primer dan absolut, ekstasis dan hipostasis, unik dan tak tergantikan. Pribadi selalu bergerak ke luar dirinya, ke arah pribadi yang lain, maka ia menerima keberbedaan. Kehidupan dan identitas otentik pribadi ditemukan hanya di dalam komunitas yang dibangunnya bersama pribadi-pribadi yang lain. Gerak Pribadi Allah adalah eros, cinta yang merangkul pribadi-pribadi yang lain beserta keberbedaan mereka, yakni manusia dan segenap ciptaan. Berkomunitas dengan Allah dan segenap ciptaan, manusia melampaui substansi manusiawi dan kondisi naturalnya. Manusia tidak lagi menjadi milik kematian melainkan kehidupan kekal. Gereja adalah image Allah Trinitaris karena ia adalah komunitas pribadi-pribadi yang mengalami kelahiran baru oleh Roh Kudus di dalam peristiwa Kristus. Sebagai image Allah Trinitaris, cara Gereja hadir di dunia ialah dengan menjadi komunitas katolik dan ekaristis. Untuk menjadi komunitas katolik-ekaristis, pembaruan cara hidup, struktur hirarkis, dan pelayanan Gereja adalah sebuah kebutuhan.
Kata-kata Kunci: pribadi, substansi, ekstasis-hipostasis, keberbedaan, identitas otentik, komunitas ekaristis, imago Dei/Trinitatis, eros.
Abstract: John Zizioulas did his reflection on the doctrine of the Trinity in term to seek new ways that help the faithful to grasp the meaning of this teaching. Referring to the theology of Cappadocian Fathers, Zizioulas provides a picture of the Trinity as Persons within communion. A person has three primary characteristics: primary and absolute, ecstatic and hypostatic, unique and irreplaceable. A person always moves towards others, thus she/he embraces otherness. The very life and authentic identity of a person can be found only in communion with others. The Person of God moves as eros, God’s love which embraces the others and otherness, i.e. human beings and the rest of creation. Being in communion with God and all creations, human being overcomes the human substance and its nature. Human being no longer belongs to death but to eternal life. The church is an image of the Trinity for it is a communion of the new persons that were delivered by the Holy Spirit within the Christ event. As the image of the Trinity, the Church’s way of being in this world is by becoming a catholic and eucharistic community. To be such a community, the renewal of the Church’s way of life, hierarchical structure, and ministries is a necessity.
Kata-kata Kunci: Person, substance, ecstatic-hypostatic, otherness, authentic identity, eucharistic community, image of God/image of the Trinity, eros.
TEKNOLOGI FITOREMEDIASI UNTUK PENANGANAN PENCEMARAN LOGAM BERAT DI LAHAN PERTANIAN DI KECAMATAN KEBAKKRAMAT KABUPATEN KARANGANYAR
Authors: Rosariastuti MMA. Retno , Supriyadi Supriyadi , Widiastuti Wiwin 
Published: November 2020

Research aim of heavy metal pollution handling in agricultural land use fitoremediation technologyis to know the effectivity of hemp and mendong plant used and it’s combination with rhizobacterial isolates Agrobacterium sp I3 or organic materials in order to decrease the levels of heavy metal contamination in the soil such as cromium (Cr), cadmium (Cd) and plumbum (Pb).The research was conducted in Waru Village Kebakkramat Sub-District Karanganyar Regency in 2016. The location is a subdistrict in Karanganuyar Regency whose area has many industries, mainly textile industry.Industrial wastewater in this region is widely used to irrigate rice fields by farmers, so the paddy fields have been polluted by Cr, Cd and Pb.Therefore, it is necessary to decrease the contamination of heavy metals in paddy fields with the selection of environmentally friendly remediation technology, low cost, easy and sustainable.The method of remediation in that category is bioremediation using a plant called phytoremediation.For that required plants that have rapid growth and high metal absorption capability.The character are owned by hemp and mendong plants.Based on previous research obtained Agrobacterium sp I3 rhizobacteria which proved able to increase the uptake of Cromium by hemp plant.The research result showed that hemp and mendong plants can absorb metal either Pb, Cd, or Cr.Based on the amount of metal absorption value in root and plant canopy, hemp plant and mendong shows its ability as hyper akumulator plant (the amount of uptake ≥ 100 ppm).The highest decrease of soil Pb content was 39,406% without treatment of basic fertilizer, with rhizobacterial inoculation Agrobacterium sp I3 and hemp plant.The highest decrease of soil Cd content was 56,604% with treatment with basic fertilizer, with inoculation of rhizobacteria Agrobacterium sp I3 and mendong plant.The highest decrease of Cr content of soil was 42,27% with treatment of basic fertilizer, without inoculation of Agrobacterium sp sp I3 and without hemp and mendong plants.
A narrative review of ambulatory care education in Canadian internal medicine
Authors: Spiegle Gillian , Yin Penny , Wright Sarah , Ng Stella , O'Brien Tara , Friesen Farah , Friesen Michael , Shah Rupal 
Published: November 2020

Background: The Canadian healthcare system faces increasing patient volumes and complexity amidst funding constraints. Ambulatory care offers a potential solution to some of these challenges. Despite growing emphasis on the provision of ambulatory care, there has been a relative paucity of ambulatory care training curricula within Canadian internal medicine residency programs. We conducted a narrative review to understand the current state of knowledge on postgraduate ambulatory care education (ACE), in order to frame a research agenda for Canadian Internal Medicine ACE.
Methods: We searched OVID Medline, Embase, and PsycINFO for articles that included the concepts of ambulatory care and medical or health professions education from 2005-2015. After sorting for inclusion/exclusion, we analyzed 30 articles, looking for dominant claims about ACE in Internal Medicine literature.
Results: We found three claims. First, ACE is considered to be a necessary component of medical training because of its distinction from inpatient learning environments. Second, current models of ambulatory care clinics do not meet residency education needs. Third, ACE presents opportunities to develop non-medical expert roles.
Conclusions: The findings of our narrative review highlight a need for additional research regarding ACE in Canada to inform optimal ambulatory internal medicine training structures and alignment of educational and societal needs.
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LEDIPASVIR AND SOFOSBUVIR IN BULK DRUG BY USING RP-HPLC
Authors: RowthulaPrasanna Surya Bhavani Rowthula Prasanna Surya Bhavani , M.Sandhya Maduri M.Sandhya Maduri 
Published: November 2020

A new, simple, precise, accurate, and reproducible RP-HPLC for stability-indicating method development and validation of Ledipasvir and Sofosbuvir in bulk form. Separation ofLedipasvir and Sofosbuvir was successfully achieved Dona Zorbax C8, 250 X4.6mm, 5µm or equivalent in an isocratic mode utilizing 0.1% OPA: Methanol (45:55) at a flow rate of 1.0mL/min and the eluate was monitored at 238nm, with a retention time of 3.303 and 7.303minutes for Ledipasvir and Sofosbuvir respectively. The method was validated and their response was found to be linear in the drug concentration range of 45µg/ml to135 µg/ml for Ledipasvirand 200µg/ml to 600 µg/ml for and Sofosbuvir. The values of the correlation coefficient were found to 0.999 for Ledipasvirand 1 for Sofosbuvir respectively. The LOQ for Ledipasvirwere found to be 0.695 respectively. The LOQ for Sofosbuvir was found to be 2.2063 respectively. This method was found to be a good percentage recovery for Ledipasvir and Sofosbuvirwere found to be 100 and 100 respectively indicates that the proposed method is highly accurate. The specificity of the method shows a good correlation between retention times of standard with the sample so, the method specifically determines the analyte in the sample without interference from the excipients of tablet dosage forms. The method was extensively validated according to ICH guidelines for Linearity, Accuracy, Precession, Specificity, and Robustness.
Laisvos DNR reikšmė diagnozuojant plaučių vėžį
Authors: Serapinas Danielius , Medvedeva Arina , Čepaitė Justė , Mickevičiūtė Giedrė 
Published: November 2020

Tradiciškai vėžio diagnozė nustatoma taikant histologinius ir radiologinius tyrimo metodus, tačiau tobulėjant molekuliniams tyrimo metodams, atrandama vis daugiau biožymenų, kurie padeda vėžį klasifikuoti į molekulinius tipus. Remiantis šiais molekuliniais tipais, galima skirti navikui specifinį gydymą ir sulaukti geresnių rezultatų. Daugumai biožymenų aptikti ir nustatyti reikalingos invazinės procedūros: chirurginė naviko ekscizija, biopsijos paėmimas ar plonos adatos aspiracija. Tuo tarpu aptikti ir ištirti laisvą DNR (ang. cell free DNA, cfDNA) tereikia minimaliai invazinės procedūros, vadinamosios skystos biopsiijos. cfDNR - jautrus, specifiškas biožymuo, suteikiantis galimybę anksti nustatyti naviko diagnozę, stebėti naviko masę, liekamąją ligą bei atsparumą gydymui. cfDNR atspindi visą naviko genomą bei navikui būdingą heterogeniškumą, o tai leidžia skirti pacientui individualizuotą gydymą.