bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPACT-Scot report on COVID-19 and hip fractures
Authors: Hall Andrew J. , Clement Nicholas D. , Farrow Luke ,   IMPACT-Scot Study Group, MacLullich Alasdair M. J. , Dall Graham F. , Scott Chloe E. H. , Jenkins Paul J. , White Timothy O. , Duckworth Andrew D. 
Published: July 2020

Aims The primary aim was to assess the independent influence of coronavirus disease (COVID-19) on 30-day mortality for patients with a hip fracture. The secondary aims were to determine whether: 1) there were clinical predictors of COVID-19 status; and 2) whether social lockdown influenced the incidence and epidemiology of hip fractures. Methods A national multicentre retrospective study was conducted of all patients presenting to six trauma centres or units with a hip fracture over a 46-day period (23 days pre- and 23 days post-lockdown). Patient demographics, type of residence, place of injury, presentation blood tests, Nottingham Hip Fracture Score, time to surgery, operation, American Society of Anesthesiologists (ASA) grade, anaesthetic, length of stay, COVID-19 status, and 30-day mortality were recorded. Results Of 317 patients with acute hip fracture, 27 (8.5%) had a positive COVID-19 test. Only seven (26%) had suggestive symptoms on admission. COVID-19-positive patients had a significantly lower 30-day survival compared to those without COVID-19 (64.5%, 95% confidence interval (CI) 45.7 to 83.3 vs 91.7%, 95% CI 88.2 to 94.8; p < 0.001). COVID-19 was independently associated with increased 30-day mortality risk adjusting for: 1) age, sex, type of residence (hazard ratio (HR) 2.93; p = 0.008); 2) Nottingham Hip Fracture Score (HR 3.52; p = 0.001); and 3) ASA (HR 3.45; p = 0.004). Presentation platelet count predicted subsequent COVID-19 status; a value of < 217 × 109/l was associated with 68% area under the curve (95% CI 58 to 77; p = 0.002) and a sensitivity and specificity of 63%. A similar number of patients presented with hip fracture in the 23 days pre-lockdown (n = 160) and 23 days post-lockdown (n = 157) with no significant (all p ≥ 0.130) difference in patient demographics, residence, place of injury, Nottingham Hip Fracture Score, time to surgery, ASA, or management. Conclusion COVID-19 was independently associated with an increased 30-day mortality rate for patients with a hip fracture. Notably, most patients with hip fracture and COVID-19 lacked suggestive symptoms at presentation. Platelet count was an indicator of risk of COVID-19 infection. These findings have implications for the management of hip fractures, in particular the need for COVID-19 testing. Cite this article: Bone Joint J 2020;102-B(9):1219–1228.
High contrast multimode fiber imaging based on wavelength
modulation
Authors: Zhang Xuanhao , Wen Zhong , Ma Yaoguang , Liu Xu , Wang Liqiang , Yang Qing 
Published: July 2020

The property of the multimode fiber (MMF) to remain minimally invasive
when performing high-resolution observations, makes MMF imaging of
particular interest in many related fields recently, especially in
bioendoscopic imaging. Imaging through point scanning is the most
common method of MMF imaging now, which means modulating a scanning
focal spot on the end face of fiber by controlling modes in the fiber.
However, due to mode interference, there is always a background
speckle around the focal spot formed, which affects imaging quality
seriously. Increasing controllable modes number can effectively
suppress the effects of the background speckle, but it is limited by
the number of controllable elements (the elements number of wavefront
shaping devices). Here, we propose a new, to the best of our
knowledge, method to increase the contrast-to-noise ratio (CNR) of MMF
imaging without increasing the number of controllable modes.
Wavelength modulation is introduced to suppress the background. The
background speckles turn to be uncorrelated, whereas the signal
patterns turn to be strongly correlated and can be added when 20
different wavelengths of light form a focal spot at the same position
at the distal end of MMF, respectively. Thus, a four-fold enhancement
can be gained in CNR at a 200 µm field-of-view (FOV) by suppressing
background speckles.
Intracavity birefringence-controlled GHz-tuning range passively harmonic mode-locked fiber laser based on NPR
Authors: Ling Yuanda , Huang Qianqian , Song Qingguo , Yan Zhijun , Mou Chengbo , Zhou Kaiming , Zhang Lin 
Published: July 2020

We experimentally demonstrate a harmonic-order controllable L-band Er-doped passively mode-locked fiber laser based on nonlinear polarization rotation (NPR). Distinct from all previous reports, we find that the intracavity birefringence is able to control the harmonic order of a passively mode-locked fiber laser. Experimentally, under a constant pump power of 704 mW, the harmonic order can be tuned from 113th to 39th monotonically by adjusting the polarization controller orientation only. The corresponding repetition rate changes from 2.21 to 0.77 GHz simultaneously. Remarkably, the super-mode suppression ratio of each harmonic order we observed is higher than 29 dB with a maximum of 36.5 dB. Simulated transmission spectra of NPR prove that the changed transmission plays an important role in controlling the harmonic order.
MoS2-based broadband and highly efficient solar absorbers
Authors: Sun Zhanshan , Huang Fumin , Fu Yunqi 
Published: July 2020

In order to obtain broadband, highly efficient, wide-angle, and polarization-insensitive solar absorbers, we propose a universal configuration consisting of monolayer molybdenum disulfide (

M
o
S

2

) and the metal-insulator-metal structure, which gives rise to significant absorption enhancement of the

M
o
S

2

layer. Light trapping structures with silver square-, circle-, and crossed-shaped resonators are investigated. The localized surface plasmon resonances among the silver resonators induce prominent interaction between the incident photon and

M
o
S

2

layer, contributing to efficient absorption of light energy. Simulation results show that the absorber made of square patches enables the best performance and realizes absorptance higher than 90% from 400 to 666 nm and an average absorptance greater than 91% in the range of 400–700 nm. The average light absorption within the

M
o
S

2

layer reaches 74% in the visible spectrum, which is one of the highest levels for the existing

M
o
S

2

-based absorbers. Meanwhile, the polarization-independent designs exhibit good angle tolerance within 50° incidences. Such a universal structure can also obtain broadband and highly efficient absorption by using other transition metal dichalcogenides such as

M
o
S
e

2

,

W
S

2

, and

W
S
e

2

, which indicates that the configuration has great applicability in solar energy absorption of 2D materials. The proposed solar absorbers with simple configuration and broadband absorption in wide incident angles have potential in applications such as solar cells, photovoltaic devices, and blackbody materials.
The Limits of Auteurism: Case Studies in the Critically Constructed New Hollywood, Nicholas Godfrey (2018)
Authors: Bugeja Nick 
Published: July 2020

Review of: The Limits of Auteurism: Case Studies in the Critically Constructed New Hollywood, Nicholas Godfrey (2018)
New Brunswick: Rutgers University Press, 282pp., ISBN: 9780813589145 (pbk), $27.95
Penanganan Konsultasi Hukum Di Badan Konsultasi Hukum Fakultas Hukum Undip 2018
Authors: Adhim Nur 
Published: July 2020

N a m a : Muhsonalia (Ahli Waris)Alamat : RT 03/ RW 03 Kel. Mangunharjo Kec. Tugu Kota semarangTelp : 082 226 246 635Topik Kasus: Masalah Tanah.
Eksistensi Yurisprudensi Mahkamah Agung (MA) Dalam Penegakan Hukum Keluarga Islam Indonesia
Authors: Islamiyati Islamiyati , Agus Priyono Ery , Hendrawati Dewi , Arief Budiman Achmad 
Published: July 2020

Pendapat kontra atas yurisprudensi hakim MA tentang hukum keluarga Islam sangat mengganggu eksistensi penegakaan keadilan, karena dasar hukumnya sering bertentangan dengan teks perundang-undangan. Penelitian menganalisis apakah dan sejauhmanakah yurisprudensi MA dapat menegakkan hukum keluarga Islam Indonesia. Jenis penelitian ini adalah library research (penelitian kepustakaan), data yang dibutuhkan data sekunder. Metode pendekatannya adalah yuridis doktrinal, dan data dianalisis secara kualitatif. Produk penelitian menerangkan bahwa yurisprudensi MA adalah salah satu produk pemikiran hukum Islam dari lembaga peradilan, hakim berperan penting menegakkan hukum Islam karena hakim tidak terlepas dari ijtihad untuk menemukan hukum melalui pemahaman dan pemaknaan UU. Eksistensi yurisprudensi digunakan dasar pertimbangan hukum hakim PA dalam menyelesaikan perkara, mampu mengukuhkan penguatan hukum dan penyelesaian problem hukum keluarga Islam secara adil dan benar berpijak pada prinsip dasar syariah Islam.
Kebijakan Penjaminan Tanah Melalui Hak Tanggungan di Indonesia (Studi Penjaminan Hak Tanggungan Elektronik di Kabupaten Badung Provinsi Bali)
Authors: Santi Dewi IGA Gangga , Ardani Mira Novana 
Published: July 2020

Penjaminan Hak Tanggungan diatur dalam dua kebijakan yaitu Undang-Undang No. 4 Tahun 1996 dan PMATR/KBPN No. 9 Tahun 2019. Pada kedua kebijakan tersebut tidak ada keharusan atau kewajiban untuk dilakukan secara manual atau secara elektronik.Di Kabupaten Badung Provinsi Bali telah dilakukan pemberian Hak Tanggungan secara elektronik dimana PPAT hanya bertugas menyampaikan Akta Pemberian Hak Tanggungan beserta berkasnya secara online dan tidak melakukan pendaftaran Hak Tanggungan di Kantor Pertanahan.Permasalahan timbul ketika dalam kedua kebijakan tersebut tidak menyebutkan hak dan kewajiban masing-masing pihak secara jelas dalam pendaftaran HT juga kewenangan pemberian HT untuk obyek HT. Terdapat perbedaan secara signifikan dalam ketentuannya antara kebijakan penjaminan Hak Tanggungan menurut Undang-Undang No. 4 Tahun 1996 dengan penjaminan Hak Tanggungan berdasarkan PMATR/ KBPN No. 9 Tahun 2019 terkait pemberian dan pendaftaran Hak Tanggungan.
Batasan Hukum Keterbukaan Data Medis Pasien Pengidap Covid-19: Perlindungan Privasi VS Transparansi Informasi Publik
Authors: Rizki Prananda Rahandy 
Published: July 2020

Persebaran infeksi virus Covid-19 telah mengalami peningkatan sejak temuan kasus pertama. Wacana pembukaan akses data rekam medis Pasien Positif Covid-19 menimbulkan pro kontra dalam masyarakat. Artikel ini bertujuan untuk mengkaji perspektif sejumlah regulasi dalam memandang status data rekam medis, bentuk perlindungan hukum dan implikasinya , serta solusi hukum untuk praktek yang diterapkan melalui studi komparatif dengan negara lain. Penelitian ini menggunakan metode yuridis normative dengan pendekatan Undang-Undang , konseptual dan perbandingan hukum. Hasil penelitian menunjukan bahwa Data rekam medis merupakan hak pribadi individu yang bersifat rahasia dan terbatas . Perlindungan hukum yang diberikan bagi data rekam medis pasien belum komprehensif . Guna mengantisipasi peningkatan penularan Virus Covid-19, Praktik penggunaan data pribadi pasien diterapkan oleh beberapa negara sesuai prinsip proporsionalitas , necessities dan purposive limitation.
Diorganotin(iv) benzyldithiocarbamate complexes: synthesis, characterization, and thermal and cytotoxicity study
Authors: Adeyemi Jerry O. , Onwudiwe Damian C. , Nundkumar Nirasha , Singh Moganavelli 
Published: July 2020

AbstractAmmonium benzyldithiocarbamate, represented as NH4L, was prepared and used in the complexation reaction involving three organotin(iv) salts, represented as R2SnCl2(R = CH3, C4H9, and C6H5). The structures of the synthesized complexes [(CH3)2SnL2] (1), [(C4H9)2SnL2] (2), and [(C6H5)2SnL2] (3) were established using various spectroscopic techniques (Fourier transform infrared spectroscopy,1H NMR,13C NMR, and119Sn NMR) and elemental analysis. Thermal decomposition of the complexes using thermogravimetric analysis under nitrogen showed no definite pathway in the pattern of the complexes even though they are structurally related. X-ray diffraction studies of the final residue showed a common diffraction pattern for the complexes and confirmed SnS as the product of the thermal treatment. Cytotoxicity studies of these complexes against the human tumor cell lines (HeLa and MCF-7) compared favorably with the used standard 5-fluorouracil drug, with complexes2and3showing very good activity toward the used cell lines.
Lycopene in tomatoes and tomato products
Authors: Górecka Danuta , Wawrzyniak Agata , Jędrusek-Golińska Anna , Dziedzic Krzysztof , Hamułka Jadwiga , Kowalczewski Przemysław Łukasz , Walkowiak Jarosław 
Published: July 2020

AbstractThis article focused on the content of lycopene in fresh and dried tomatoes and tomato pomace, as well as in tomato paste at different harvest times (harvest 1 – August and harvest 2 – September). The lycopene content of tomatoes and tomato products was evaluated by using high-performance liquid chromatography (HPLC). The results showed that the highest content of lycopene was estimated in the tomato paste independent of the time of harvest (211.73 mg/100 g dm in August and 184.29 mg/100 g dm in September) and the lowest content in fresh pomace (20.45 and 16.11 mg/100 g dm in August and September, respectively). Good sources of lycopene are tomato by-products, in particularly dried tomato pomace (25.11 mg/100 g dm – harvest 1 and 19.30 mg/100 g dm – harvest 2). This study showed that tomato waste can be considered as a promising source of lycopene for the production of functional foods.
Lead discovery of a guanidinyl tryptophan derivative on amyloid cascade inhibition
Authors: Suwanttananuruk Piyapan , Jiaranaikulwanitch Jutamas , Waiwut Pornthip , Vajragupta Opa 
Published: July 2020

AbstractAmyloid cascade, one of pathogenic pathways of Alzheimer’s disease (AD), was focused as one of drug discovery targets. In this study, β-secretase (BACE1) inhibitors were designed aiming at the development of multifunctional compounds targeting amyloid pathogenic cascade. Tryptophan was used as a core structure due to its properties of the central nervous system (CNS) penetration and BACE1 inhibition activity. Three amino acid residues and guanidine were selected as linkers to connect the tryptophan core structure and the extended aromatic moieties. The distance between the aromatic systems of the core structure and the extended moieties was kept at the optimal length for amyloid-β (Aβ) peptide binding to inhibit its fibrillation and aggregation. Sixteen designed compounds were evaluated in silico. Eight hit compounds of TSR and TGN series containing serine and guanidine linkers, respectively, were identified and synthesized based on docking results. TSR2 and TGN2 were found to exert strong actions as BACE1 (IC50 24.18 µM and 22.35 µM) and amyloid aggregation inhibitors (IC50 37.06 µM and 36.12 µM). Only TGN2 demonstrated a neuroprotective effect in SH-SY5Y cells by significantly reducing Aβ-induced cell death at a concentration of 2.62 µM. These results support the validity of multifunctional approaches to inhibition of the β-amyloid cascade.
Synthesis of orotic acid derivatives and their effects on stem cell proliferation
Authors: Syed Saeed Ali , Mahmood Amer , Alfayez Musaad , Hosten Eric C. , Betz Richard , Al-Obaid Abdulrahman M. , Ghadeer Abdulrahman , Bari Ahmed 
Published: July 2020

AbstractOrotic acid, a natural product, is involved in many biological processes. Human mesenchymal stem cells (hMSCs) have the potential of self-renewable and proliferation. They are commonly isolated from the bone marrow aspirates of large bones. The osteogenic potential of these stem cells has been extensively exploited by scientists in the past to evaluate the performance of synthetic scaffolds developed for tissue engineering. In this study, N-arylhydrazone derivatives of orotic acid have been synthesized, and their potential as stimulators of human mesenchymal stem cells has been evaluated. Some of the analogs exhibit well to moderate effect on the proliferation rate.
Systematic studies for improving device performance of quantum well infrared stripe photodetectors
Authors: Hainey Mel F. , Mano Takaaki , Kasaya Takeshi , Ochiai Tetsuyuki , Osato Hirotaka , Watanabe Kazuhiro , Sugimoto Yoshimasa , Kawazu Takuya , Arai Yukinaga , Shigetou Akitsu , Miyazaki Hideki T. 
Published: July 2020

Abstract
The integration of quantum well infrared photodetectors with plasmonic cavities has allowed for demonstration of sensitive photodetectors in the mid-infrared up to room-temperature operating conditions. However, clear guidelines for optimizing device structure for these detectors have not been developed. Using simple stripe cavity detectors as a model system, we clarify the fundamental factors that improve photodetector performance. By etching semiconductor material between the stripes, the cavity resonance wavelength was expected to blue-shift, and the electric field was predicted to strongly increase, resulting in higher responsivity than unetched stripe detectors. Contrary to our predictions, etched stripe detectors showed lower responsivities, indicating surface effects at the sidewalls and reduced absorption. Nevertheless, etching led to higher detectivity due to significantly reduced detector dark current. These results suggest that etched structures are the superior photodetector design, and that appropriate sidewall surface treatments could further improve device performance. Finally, through polarization and incidence angle dependence measurements of the stripe detectors, we clarify how the design of previously demonstrated wired patch antennas led to improved device performance. These results are widely applicable for cavity designs over a broad range of wavelengths within the infrared, and can serve as a roadmap for improving next-generation infrared photodetectors.
Simultaneously enhanced linear and nonlinear photon generations from WS2 by using dielectric circular Bragg resonators
Authors: Chen Bo , He Zhe , Liu Zhuo-Jun , Wang Yun-Kun , Gao Yu-Nan , Aharonovich Igor , Xu Zai-Quan , Liu Jin 
Published: July 2020

Abstract
Monolayer transition metal dichalcogenides (TMDs) have emerged as a promising platform for chip-integrated optoelectronics and non-linear optics. Here, we demonstrate a two-dimensional (2D) monolayer tungsten disulfide (WS2) efficiently coupled to a dielectric circular Bragg resonator (CBR). The coupling of the WS2 and CBR leads to pronounced enhancements in both photoluminescence (PL) and second harmonic generation (SHG) by a factor of 34 and 5, respectively. Our work provides a powerful tool to enhance the interactions between light and the 2D materials, paving the way for efficient on-chip optoelectronic devices.
Misalignment resilient diffractive optical networks
Authors: Mengu Deniz , Zhao Yifan , Yardimci Nezih T. , Rivenson Yair , Jarrahi Mona , Ozcan Aydogan 
Published: July 2020

AbstractAs an optical machine learning framework, Diffractive Deep Neural Networks (D2NN) take advantage of data-driven training methods used in deep learning to devise light–matter interaction in 3D for performing a desired statistical inference task. Multi-layer optical object recognition platforms designed with this diffractive framework have been shown to generalize to unseen image data achieving, e.g., >98% blind inference accuracy for hand-written digit classification. The multi-layer structure of diffractive networks offers significant advantages in terms of their diffraction efficiency, inference capability and optical signal contrast. However, the use of multiple diffractive layers also brings practical challenges for the fabrication and alignment of these diffractive systems for accurate optical inference. Here, we introduce and experimentally demonstrate a new training scheme that significantly increases the robustness of diffractive networks against 3D misalignments and fabrication tolerances in the physical implementation of a trained diffractive network. By modeling the undesired layer-to-layer misalignments in 3D as continuous random variables in the optical forward model, diffractive networks are trained to maintain their inference accuracy over a large range of misalignments; we term this diffractive network design as vaccinated D2NN (v-D2NN). We further extend this vaccination strategy to the training of diffractive networks that use differential detectors at the output plane as well as to jointly-trained hybrid (optical-electronic) networks to reveal that all of these diffractive designs improve their resilience to misalignments by taking into account possible 3D fabrication variations and displacements during their training phase.
Cryogenic and Aging Treatment Effects on the Mechanical Properties of Ti-15V-3Al-3Cr-3Sn Titanium Alloy
Authors: Yumak Nihal , Aslantaş Kubilay , Çetkin Ahmet 
Published: July 2020

Abstract
In this study, single and duplex aging treatment was applied to the metastable beta titanium alloy of titanium-15 vanadium-3 aluminum-3 chromium-3 tin with cryogenic treatment. The single-step aging treatment was applied for 20 h at 450°C and 10 h at 550°C. The cryogenic treatment was carried out at −196°C for 24 h, followed by single-step or duplex aging treatment. The results obtained show that the cryogenic treatment causes the formation of martensitic alpha phases. Following the cryogenic treatment, martensitic alpha phases were observed in the sample, which was subjected to aging treatment at 450°C for 20 h, whereas these phases disappeared completely in the sample treated at 550°C for 10 h. Preaging treatment applied after cryogenic treatment prevented the formation of precipitate-free zones by providing a finer and uniform distribution of α phases. Cryogenic treatment followed by preaging treatment at 250°C for 24 h led to the formation of dense metastable prephases. This resulted in a 10% increase in tensile strength, 4% elongation, and 5% hardness compared to preaging at 300°C for 10 h after cryogenic treatment. The optimum mechanical properties in single-step sample groups were obtained in samples aged 20 h at 450°C. In duplex-aged samples, optimum mechanical properties were obtained in cryogenic treatment followed by 250°C/10 h + 450°C/20 h duplex aging treatment.
Fully Phased Sequence of a Diploid Human Genome Determined de Novo from the DNA of a Single Individual
Authors: Soifer llya , Fong Nicole L , Yi Nelda , Ireland Andrea T , Lam Irene , Sooknah Matthew , Paw Jonathan S , Peluso Paul , Concepcion Gregory T , Rank David , Hastie Alex R , Jojic Vladimir , Ruby J Graham , Botstein David , Roy Margaret A 
Published: July 2020

Abstract
In recent years, improved sequencing technology and computational tools have made de novo genome assembly more accessible. Many approaches, however, generate either an unphased or only partially resolved representation of a diploid genome, in which polymorphisms are detected but not assigned to one or the other of the homologous chromosomes. Yet chromosomal phase information is invaluable for the understanding of phenotypic trait inheritance in the cases of compound heterozygosity, allele-specific expression or cis-acting variants. Here we use a combination of tools and sequencing technologies to generate a de novo diploid assembly of the human primary cell line WI-38. First, data from PacBio single molecule sequencing and Bionano Genomics optical mapping were combined to generate an unphased assembly. Next, 10x Genomics linked reads were combined with the hybrid assembly to generate a partially phased assembly. Lastly, we developed and optimized methods to use short-read (Illumina) sequencing of flow cytometry-sorted metaphase chromosomes to provide phase information. The final genome assembly was almost fully (94%) phased with the addition of approximately 2.5-fold coverage of Illumina data from the sequenced metaphase chromosomes. The diploid nature of the final de novo genome assembly improved the resolution of structural variants between the WI-38 genome and the human reference genome. The phased WI-38 sequence data are available for browsing and download at wi38.research.calicolabs.com. Our work shows that assembling a completely phased diploid genome de novo from the DNA of a single individual is now readily achievable.