bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Pollution on Child and Adolescent Mental Health: A Protocol for a Systematic Review
Authors: Theron Linda , Abreu-Villaça Yael , Augusto-Oliveira Marcus , Brennan Caroline , Crespo-Lopez Maria Elena , Arrifano Gabriela de Paula , Glazer Lilah , Lin Liyuan , Mareschal Isabelle , Sartori Luke , Stieger Liesl , Trotta Andres , Hadfield Kristin 
Published: May 2020

Abstract
Background Whilst there is little uncertainty about the deleterious impact of pollution on human and planetary health, pollution’s impact on child and adolescent mental health is less well understood. This is particularly true for young people in underdeveloped and developing world contexts, about whom research is generally lacking. Furthermore, although child and adolescent resilience continues to be a research priority, little attention has been paid to child and adolescent pathways of resilience in the face or aftermath of pollution exposure. Methods We will conduct a systematic review that adheres to PRISMA guidelines. Its purpose is to document what is known about how pollution affects child and adolescent mental health, along with what protects children and adolescents against these effects and associations across diverse contexts. Discussion Systematic insights are likely to support psychologists and other mental health practitioners to better support child and adolescent wellbeing globally regardless of exposure to pollution. Systematic review registration We have registered the review protocol in PROSPERO (registration: CRD42020176664).
Efficacy of four hollow nail rhombic fixation for the treatment of patients with femoral neck fractures: A protocol of systematic review and meta-analysis
Authors: Ji Qing-hui , Xue Yu , Miao Jie , Reng Zhi-xin , Yuan Yu-fei , Li Yan-bao 
Published: May 2020

Abstract
Background : This study aims to assess the efficacy of four hollow nail rhombic fixation (FHNRF) for the treatment of patients with femoral neck fractures (FNF). Methods : A literature search in MEDLINE, Scopus, Web of Science, EMBASE, Cochrane Library, ProQuest, Thesis and Dissertation Catalog, Cumulative Index to Nursing and Allied Health Literature, and China National Knowledge In­frastructure will be performed from inception through February 29, 2020. This study will not apply limitations to the language and publication date. All potential randomized controlled trials (RCTs) that identify the efficacy and safety of FHNRF for the treatment of patients with FNF. Two contributors will separately examine searched records, extract essential data, and assess study quality using Cochrane risk of bias tool. Any opposition between two authors will be settled by a third contributor. We will employ RevMan 5.3 software for statistical analysis. Discussion : This study will summarize high quality RCTs to assess the efficacy and safety of FHNRF for the treatment of patients with FNF. It will help to determine whether or not FHNRF is effective and safety for the treatment of patients with FNF. Systematic review registration CRD42020168378.
Glenoid Failure after Total Shoulder Arthroplasty, cemented all-polyethylene versus metal-backed: A Systematic Review Protocol
Authors: Zan Renato Aroca , Lazarini Rafael Fuchs , Matsunaga Fábio Teruo , Netto Nicola Archetti , Belloti João Carlos , Tamaoki Marcel Jun Sugawara 
Published: May 2020

Abstract
BackgroundAnatomical Total Shoulder Arthroplasty (TSA) is an effective treatment adopted in patients with glenohumeral osteoarthritis. The glenoid component failure is the main risk that occurs in this therapeutic choice; however, doubts remain, regarding the selection of the best implant in order to avoid such complication.MethodsA systematic review of randomized clinical trials (RCTs) or quasi will be carried out, applying the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocols, comparing polyethylene (keeled and pegged) versus metal back implants in adult patients with glenohumeral osteoarthritis.Our search strategy will be carried out in the MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, EMBASE, Web of Science. Data management and extraction will be performed using a data withdrawal form and by analyzing study method characteristics, participant characteristics, intervention characteristics, results, methodological domains. The summaries of research evidence will be accessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Shoulder function through functional scores such as Constant-Murley (CM) and American Shoulder and Elbow Surgeons (ASES), pain (Visual Analogue Scale), infection, procedure failure, radiograph radiolucency and loosening, are the selected outcomes. Another analysis such as subgroup, heterogeneity, sensitivity and statistical are going to be performed whenever possible.DiscussionThis systematic review aims to analyze how glenoidal implants behave in Total Shoulder Arthroplasties and therefore provide evidence concerning the best clinical practice to avoid complication. Systematic review registrationPROSPERO, CRD 42018079537.
Lipid Profile in Alcoholic and Non Alcoholic Fatty Liver Patients
Authors: Shahi Aakash , Gautam Narayan , Rawal Sanju , Sharma Uday , Jayan Archana 
Published: May 2020

Abstract
Background: Fatty liver disease is a common and major chronic liver disease. It has been implicated that patients have disorders of lipid metabolism and involved in the pathogenesis of fatty liver. Lipid profile plays a very important role in diagnosis of liver diseases hence it was designed to observe relationship between lipid profile and fatty liver disease (FLD) based on ultrasonography (USG).Method and methodology: This Cross-sectional and analytical study was undertaken in the Department of Internal Medicine with collaboration of Department of Radiology and Department of Biochemistry, Universal College of Medical Sciences-Teaching Hospital (UCMS-TH), Bhairahawa, Nepal from March 2019 to February 2020 in total 100 patients diagnosed with FLD by USG.Result: In 100 cases, the male to female ratio was 1.8:1. 56% of the total cases presented with alcoholic fatty liver disease (AFLD) while remaining 44% with non alcoholic fatty liver disease (NAFLD). The spectrum of lipid abnormality was observed with increased total cholesterol (TC), Low Density Lipoprotein (LDL), increased triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in AFLD cases as compared to NAFLD cases. However, it has been observed that TG/HDL and Non-HDL/HDL were higher in NAFLD as compared to AFLD. There was statistical significant difference in HDL (p-value: 0.019) between alcoholic fatty liver disease grade 1 (AFLG1) and non-alcoholic fatty liver disease grade 1 (NAFLG1). Moreover, it was observed statistical significant difference in HDL between AFLG2 and NAFLG2 (p-value: 0.012).Conclusion:Elevated level of TG and decreased HDL has been implicated in the precipitation of the occlusive vascular disease. These parameters in conjunction with Non-HDL/HDL and TG/HDL can be useful in early screening and monitoring of dyslipidemia in the fatty liver patients to prevent cardiovascular diseases.
Associations between length of stay and municipal characteristics for a large Norwegian stroke unit
Authors: Barra Mathias , Dahl Fredrik A. , Faiz Kashif Waqar , Lurås Hilde 
Published: May 2020

Abstract
BackgroundDeterminants of length of stay (LOS) on hospital wards is important in many planning, policy, and decision problems. Furthermore, LOS is an important parameter for cost containment, and health managers maintain a strong focus on monitoring and reducing hospital LOS. In addition to being costly, excess LOS also expose the patient to unnecessary risk of in-hospital complications. MethodsWe analysed a data set of N = 1922 admissions to the stroke unit (SU) at Akershus University Hospital between February 2012 and March 2013, which contains high quality variables pertaining to each stay, including patient characteristics and municipality residency. We explored regression models with (log-)LOS as the dependent variable, economic and demographic characteristics of the patients’ municipalities as the main predictors, controlling for several patient and admission parameters, like sex, age, and time of arrival. ResultsThe analyses showed that the municipality variables ‘share of inhabitants below the age of 67 years who are female’ and ‘nurse full time equivalents per 1000 inhabitants’ were negatively associated with LOS. ConclusionsAlthough a regression model cannot prove causal relations, a reasonable interpretation is that the given predictors capture some aspects of a municipality’s capacity for home care, which makes it possible for the SU to discharge patients relatively early.
Predictive Risk Factors of Hypertension in Sub-Saharan Africa: A Fixed Effect Modelling Study in Burundi
Authors: IRADUKUNDA Arnaud , Odjidja Emmanuel Nene , IZERE Cheilla , NTAKABURIMVO Nestor , AKIMANA Arlene 
Published: May 2020

Abstract
BackgroundHypertension, signalled by persistently high systolic and diastolic blood pressure is a major threat to public health globally. Especially in sub-Saharan African countries, this coexists with high burden of other infectious diseases, creating a complex public health situation which is difficult to address. Tackling this will require targeted public health intervention based on evidence that well defines the at risk population. In this study, using retrospective data from two referral hospitals in Burundi, we model the risk factors associated with hypertension in Burundi MethodsRetrospective data of a sample of 353 randomly selected from a population of 4,380 patients admitted in 2019 in two referral hospitals in Burundi: Military and University teaching hospital of Kamenge. The predictive risk factors were carried out by fixed effect logistic regression. Model performance was assessed by Area under Curve (AUC). Model was internally validated via bootstrapping with 2000 replications. All analysis were conducted in R.ResultsOverall, 16.7% of the patients were found to be hypertensive. After adjustment of the model for cofounding covariates, associated risk factors found were advanced age (40 years) AOR: 6.03, 95% CI: 1.86- 17.19) and above 60 years, (AOR: 12.76, 95% CI: 3.30 – 14.26). Patients comorbid with chronic kidney failure were 4.95 times more (95% CI: 1.83-15.82) to be hypertensive and among those with family history of hypertension, the adjusted risk were twice. Compared to non-smokers, smokers were 2.87 times more likely to develop hypertension (95% CI: 0.87 – 9.15).The highest probabilities are observed to patients who are at the same time smokers, overweight, with chronic kidney failure, family history with hypertension with secondary or university as highest educational level. The model had an excellent predictive performance (AUC), accurately predicting 88.71% (95% CI: 84.17%-92.5%) of all observations Conclusion The relatively high prevalence and associated risk factors of hypertension in Burundi raises a call for concern especially in this context where there exist an equally high burden of infectious diseases, other chronic diseases including chronic malnutrition. Targeting interventions based on these identified risk factors will allow judicious channel of resources and effective public health planning.
Antibiotic resistance among the Lahu hill tribe people in northern Thailand: a cross-sectional study
Authors: INTAHPHUAK SOPHAPHAN , APIDECHKUL TAWATCHAI , KUIPIAPHUM PATITA 
Published: May 2020

Abstract
Background
Antibiotic resistance is often reported and is of major concern as a public health problem. The hill tribe people in Thailand are considered populations vulnerable to antibiotic resistance due to their poor economic and educational status. The study aimed to estimate the prevalence of, the factors associated with, and the major species of bacteria involved in antibiotic drug resistance among the Lahu hill tribe people in northern Thailand.
Methods
A cross-sectional study was conducted to gather information from participants between March and September 2019. A validated questionnaire was used for data collection. Participants who presented an illness related to infectious diseases were eligible to participate in the study and were asked to obtain specific specimens. Antibiotic susceptibility was tested by the Kirbey-Bauer disk diffusion test. Chi-square tests and logistic regression were used to detect the associations between variables at the significance level of α = 0.05.
Results
A total of 240 participants were recruited into the study; 70.4% were females, 25.4% were aged 30–40 years. More than half worked in the agricultural sector (55.4%) and had an education level of less than primary school (45.8%). The majority had urinary tract infections (67.9%) with two major pathogenic species of the infection: Escherichia coli (12.8%) and Enterobacter cloacae (8.0%). The prevalence of antibiotic resistance was 16.0%. Escherichia coli and Klebsiella pneumoniae species were found to have multidrug resistance that was greater than that of other species, while ampicillin was found to have the greatest drug resistance. In the multivariate model, it was found that those who had poor knowledge of antibiotic use had a 2.56-fold greater chance (95% CI = 1.09–5.32) of having antibiotic resistance than did those who had good knowledge of antibiotic use, and those who had poor antibiotic use behaviors had a 1.79-fold greater chance (95% CI = 1.06–4.80) of having antibiotic resistance than did those who had good antibiotic use behaviors.
Conclusion
Effective public health interventions are urgently needed to reduce antibiotic drug resistance among the Lahu people by improving their knowledge and skills regarding the proper use of antibiotics and eventually minimizing antibiotic resistance.
Avian Leukosis Virus Subgroup J Infection Alters Viral Composition in the Chicken Gut
Authors: Chen Yuan , Li Hongwei , Cong Feng , Lian Yue-xiao 
Published: May 2020

Abstract
Background Chicken is one of the economically important poultry species. ALV-J has emerged as a serious cause of mortality and suboptimal performance of domestic chickens. The changes in the virome may contribute to pathogenesis. Thus, it is important to investigate the effects of ALV-J infection on the composition of virome in chicken.Results Our results indicated that the chicken gut virome contained a diverse range of viruses, and at the order, family, genus, and species levels, there was a significant difference in virome between the ALV-J-infected chickens and controls. The predominant order was Herpesvirales, accounting for more than 96% of the chicken gut virome. Furthermore, the relative abundance of Caudovirales in the controls was higher than that in the AVL-J-infected chickens. At the family level, the relative abundance of Herpesviridae, Myoviridae, Alloherpesviridae, and Genomoviridae was significantly altered in the AVL-J-infected chickens compared with the controls. Additionally, the relative abundance of 15 genera showed a significant difference between the AVL-J-infected chickens and controls. Interestingly, the relative abundance of 366 species showed significant differences between the AVL-J-infected chickens and controls.Conclusions Our results indicated that the chicken gut virome contained a diverse range of viruses from invertebrates, vertebrates, plants, and phages. Furthermore, at the order, family, and genus levels, AVL-J infection significantly altered the chicken gut virome composition. The results will increase our understanding of the viral diversity and the changes in chicken virome, with implications in chicken health.
Associations Between the NLRP3 and IL-1β Gene Polymorphisms and Gout Susceptibility
Authors: Rui Li , Chen Wujin , Ji Kun , Miao Lei , Zhang Bei , Kahaer Mayina , Shan Jiaoyu , Nuli Rebiya , Sun Yuping 
Published: May 2020

Abstract
Objective Gout is a common form of inflammatory arthritis which characteristics by joint and surrounding soft tissues pain with sudden onset,fever,redness and swelling,caused by the monosodium urate crystals deposited.Studies have demonstrated that genetic factors occupies a certain role in the pathogenesis of gout.Therefore,in our study we aimed to explore the associations between the NLRP3 and IL-1β gene polymorphisms and gout susceptibility,in order to provide experimental basis for the diagnosis and treatment of gout furtherly.Methods We selected 715 Han individuals as our research object which included 267 male gout patients and 448 male healthy controls.Recorded demographic informations and collected blood samples.Then measured biochemical indicators and extracted the genomic DNA.The genotypes of NLRP3 gene rs7525979,rs3806268 and rs10754558 loci and IL-1β gene rs16944,rs1143623 and rs1143634 loci were detected through polymerase chain reaction(PCR) amplification technique.All data were analysised used Statistical Package for Social Sciences version 23.0(SPSS 23.0) software.Results The distribution of genotype and allele frequency were significant differences in gout patients and controls for rs3806268 of NLRP3 gene and rs1143634 of IL-1β gene(P༜0.05).NLRP3 gene rs3806268 loci AA genotype compared with GG genotype in additive model(OR = 0.58,95%CI:0.41–0.84) and AA genotype compared with GG + GA genotype in recessive model(OR = 0.61, 95%CI:0.44–0.85) and IL-1β gene rs1143634 loci AA + GA genotype compared with GG genotype in dominant model(OR = 0.45, 95%CI:0.24–0.84) could reduced the risk of gout.TC and LDL-C concentrations were significantly differences when gout patients were divided into AA + GA and GG genotype groups (P༜0.05).Conclusion There are some associations between rs3806268 of NLRP3 gene and rs1143634 of IL-1β gene and gout susceptibility.Rs3806268 and rs1143634 loci variants may be the protect factors of gout.
Assessment of the Learning Curve of Supercapsular Percutaneously-assisted Total Hip Arthroplasty in an Asian Population
Authors: Lei Pengfei , Liao Zhan , Peng Jiang , Li Guang , Zhou Qian , Xiao Xiao , Yang Chunhua 
Published: May 2020

Abstract
Background: The supercapsularpercutaneously-assisted total hip (SuperPATH) approach is a micro-invasive approach that was developed to minimize surgical disruption of soft-tissue during routine total hip arthroplasty (THA). This study aimed to assess early outcomes and learning curves of the SuperPATHapproachin one Chinese hospital’s experience.Methods: Early outcomes of the first consecutive 78SuperPATH cases (80 hips) performed by same surgeon were evaluated. The patients were divided into 4 groups according to the surgical order. The incision, intraoperative blood loss, hospital stay, Harris hip score and complications occurrence in each group were evaluated. Learning curves were assessed using operative time and intraoperative blood loss as surrogates.Results:The operation time and intraoperative blood loss of group A and B was more than that of group C and D, and the difference was statistically significant (P<0.05), however there was no statistically significant difference between the two groups (group A vs. group B, P=0.426; group A vs. group B, P=0.426).There was no statistically significant difference in terms of incision length and hospital stay and Harris hip score at the last follow-up was increased with statistically significant difference when compared with that of preoperative among the 4 groups. One case of periprosthetic fracture occurred in group A. No other complication, such as joint dislocation, sciatic nerve injury, prosthesis loosening, periprosthetic infection and deep vein thromboembolism, occurred in 4 groups.Conclusion:In summary, for surgeons who familiar with the standard posterolateral approach, they could achieve more familiar with SuperPATH after 40 case of surgery.
CA9 is an important molecular marker for the prognosis of osteosarcoma patients
Authors: Chen Jiguang , Wang Jian , Wang An , Yu Jiangming 
Published: May 2020

Abstract
Background

As a common malignant bone tumor, osteosarcoma (OS) progresses rapidly and recurs easily. This study is aimed to build a risk score system for OS patients.
Methods

From The Cancer Genome Atlas and Gene Expression Omnibus databases, the RNA-seq data of OS (the training set) and GSE39055 (the validation sets) separately were obtained. Combined with limma package, the differentially expressed lncRNAs (DE-lncRNAs) and mRNAs (DE-mRNAs) between recurrence and non-recurrence groups were analyzed. After the RNAs correlated with independent prognosis were screened using survival package, risk score systems were constructed and the optimal one was selected. For the independent clinical prognostic factors identified by survival package, stratification analysis was conducted. Using Gene Set Enrichment Analysis, pathways were enriched for the differentially expressed genes (DEGs) between high and low risk groups.
Results

For recurrence and non-recurrence groups, 319 DE-mRNAs and 14 DE-lncRNAs were identified. Subsequently, 10 DE-mRNAs (including ALDH1A1, CA9, GMDS, LCMT2, LRRC75A, METTL1, RAB29, TADA2B, TDRD7, and TIGD2) and eight DE-lncRNAs were found to be correlated with independent prognosis. From the four risk score systems, the mRNA expression status-based risk score system was selected as the optimal one. Among the three independent clinical prognostic factors, age and recurrence were significantly related to overall survival in high risk group. Additionally, vascular smooth muscle contraction, and glycine, serine and threonine metabolism were enriched for the DEGs between high and low risk groups.
Conclusion

The mRNA expression status-based risk score system might be devoted to predict the prognosis of OS patients.
Effectiveness of electroacupuncture for the treatment of urinary incontinence in patients with spinal cord injury: a protocol of systematic review of randomized controlled trials
Authors: Wang Tian-shu , Wang Zeng-mian , Song Wei-dong , Tang Zhao-chen , Zhao Yu 
Published: May 2020

Abstract
Background The objective of this study is to examine the effectiveness and safety of electroacupuncture (EA) in the treatment of urinary incontinence (UI) in patients with spinal cord injury (SCI). Methods All potential studies will be retrieved from the electronic databases of MEDLINE, EMBASE, Cochrane Library, PsycINFO, Web of Science, CBM, and China National Knowledge Infrastructure from origin of each database up to January 31, 2020. Additionally, we will check other resources, such as Google scholar, dissertations, conference proceedings, and reference lists of included studies. No language and publication date limitations will be considered in the literature resources search. All randomized controlled trials using EA for the treatment of UI in patients with SCI will be included. Two independent investigators will perform study selection, data extraction and study quality assessment. If any conflicts occur, we will invite a third investigator to solve them. Cochrane risk of bias will be used for study quality assessment, and RevMan 5.3 software will be employed for statistical analysis. Discussion This study will summarize the most recent evidence to assess the effectiveness and safety of EA for the treatment of UI in patients with SCI. The results of this study will provide helpful evidence to determine whether EA is effective and safety for the treatment of UI in patients with SCI or not.