bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort
Authors: Alakuş Hüseyin , Kaya Mustafa , Özer Hatice , Eğilmez Hatice Reyhan , Karadayı Kürşat 
Published: January 2021

Objective: Gastric cancer is among the most common human cancers with high mortality rates. ADAM10, a member of the ADAM (a disintegrin and metalloproteinase) family has also been found to be associated with gastric carcinoma and has been suggested as a potential therapeutic target. Here, we investigated the association of ADAM10 expression with prognosis in gastric adenocarcinoma patients that underwent gastric resection with D2 lymph node dissection.
Methods: Total 86 consecutive patients that underwent resection for gastric adenocarcinoma were included. Immunohistochemical ADAM10 expression and its association with clinicopathological parameters were analyzed. Univariate and multivariate analyses and survival analyses were performed using SPSS ver.22.
Results: High grade tumors, advanced stage tumors and diffuse type tumors showed significantly worse prognosis. A statistically significant association between ADAM10 expression and overall survival (OS) was observed in the univariate analysis, however, this association did not maintain its significance in the multivariate analysis. No statistically significant association was found ADAM-10 expression and clinicopathological parameters.
Conclusion: Immunohistochemical ADAM10 expression may be used as a prognostic marker in gastric adenocarcinoma, however, introduction of a standardized immunohistochemical scoring system seems to be necessary for evaluation of ADAM10 staining.
doi: https://doi.org/10.12669/pjms.37.2.3613
How to cite this:Alakus H, Kaya M, Ozer H, Egilmez HR, Karadayi K. ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort. Pak J Med Sci. 2021;37(2):543-549. doi: https://doi.org/10.12669/pjms.37.2.3613
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical dental students’ knowledge regarding proper dental settings for treating patient during COVID-19: A cross-sectional study
Authors: Aljarbou Fahd , Bukhary Sundus , Althemery Abdullah , Alqedairi Abdullah 
Published: January 2021

Objectives: To investigate the clinical dental students’ knowledge on the proper dental setting during COVID-19.
Methods: Using multicenter cross-sectional study, a 10-items questionnaire was distributed in April 2020 among senior dental students from two dental schools. It comprised three main domains: demographic questions, questions investigating student’s access to the proper recommendations of dental settings during COVID-19 and the specific recommendations questions.
Results: The questionnaire was sent to 654 clinical dental students and the total number of respondents were 267 representing a response rate of 40.83%. The overall knowledge mean was low (1±0.92). Gender was not a statistically significant factor affecting the knowledge score (P > 0.05). Most of the participants never visited the Saudi Center for Disease Prevention and Control (Saudi CDC) website and received no guidance or advice regarding proper dental practices during COVID-19. A statistically significant relationship was observed between the mean knowledge score and access to knowledge variables (P < 0.05).
Conclusion: It was noted that clinical dental students have low knowledge on the proper dental settings during COVID-19 pandemic that was recommended by the Saudi CDC guidelines and they must be equipped with adequate knowledge from reliable sources to overcome their insufficiencies such as a well-structured and dynamic curriculum.
doi: https://doi.org/10.12669/pjms.37.2.3768
How to cite this:Aljarbou FA, Bukhary SM, Althemery AU, Alqedairi AS. Clinical dental students’ knowledge regarding proper dental settings for treating patient during COVID-19: A cross-sectional study. Pak J Med Sci. 2021;37(2):503-509. doi: https://doi.org/10.12669/pjms.37.2.3768
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Epidemiological trends in community acquired acute Kidney Injury in Pakistan: 25 years Experience from a Tertiary Care Renal Unit
Authors: Naqvi Rubina 
Published: January 2021

Background: Epidemiological studies of community acquired acute kidney injury (AKI) are sparse especially from South Asia and none has published from Pakistan. Reported incidences from different countries vary with use of different criteria of defining AKI. There is also variation found in different class of income countries, hospital based versus community based AKI.
Methods: The current study was carried out in all adult AKI patients developing community acquired AKI and coming to a tertiary care renal institution from January 1990 to December 2014. This is a retrospective data collection from patient’s records and AKI was defined according to KDIGO guidelines. Trends among different groups which are classified in medical, obstetrical and surgical were observed and presented.
Results: In medical AKI there has been found a rise in toxic rhabdomyolysis, vivax malaria and dengue infection during later part of study. In obstetrical AKI observed continuous rise in numbers contributing to total AKI during these years. Surgical AKI included obstructed cases during initial ten years and only surgical trauma during later 15 years. Older age on presentation in medical AKI, and thrombocytopenia, deranged coagulation, deranged liver function, hyperkalemia, requirement of mechanical ventilation and multi organ failure in all groups remained predictors of higher mortality.
Conclusion: From Pakistan epidemiology for community acquired AKI has never been published on a large scale and this study would remain source of great information in this regard over coming years.
doi: https://doi.org/10.12669/pjms.37.2.3876
How to cite this:Naqvi R. Epidemiological trends in community acquired acute Kidney Injury in Pakistan: 25 years Experience from a Tertiary Care Renal Unit. Pak J Med Sci. 2021;37(2):312-319. doi: https://doi.org/10.12669/pjms.37.2.3876
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Band-Pass Filter Microstrip at 3 GHz Frequency Using Square Open-Loop Resonator for S-Band Radar Applications
Authors: Maulidini Rima Anisa , Hidayat M. Reza , Praludi Teguh 
Published: January 2021

In telecommunication, filters are often used to pass the desired frequency. One of them is the Band-Pass Filter (BPF) which is passing signals between the upper cut-off frequency and the lower cut-off frequency. This research aims to make a band-pass filter that can pass 3 GHz frequency with a bandwidth of 200 MHz. This filter is designed with a square open-loop resonator simulated using Advanced Design System (ADS) software. The filter is made using FR 4-epoxy substrates with a dielectric constant (ε ) of 4.6 and substrate thickness (h) of 1.6 mm. Based on the simulation results obtained in the form of a comparison graph between the response of magnitude to frequency, it shows that the value of the return loss (S 11 ) parameter of -23.549 dB, insertion loss (S 21 ) parameter value of -1.397 dB, and a slightly shifted middle frequency of 2.890 GHz. Then for the measurement results obtained a parameter value return loss (S 11 ) of -16.364 dB, parameter value insertion loss (S 21 ) of -3.561 dB with a center frequency of 3.185 GHz.
Constitutional Complaint Sebagai Penambah Kewenangan Baru Dalam Undang-Undang Mahkamah Konstitusi Republik Indonesia
Authors: Komariah Nurul , Ridwan Muhammad Romadhoni Nur Matori , Vabesta Alivia , Damayanti Ginanjar , Nariyah Siti 
Published: January 2021

Guarantee the rights of every citizen for violations of constitutional rights by seeking to increase the authority of the Judicial Review Request by every justice seeker for violations of constitutional rights, but not at least the petition was granted. The Mahkarnah of the Constitution, which checks what the petition is made of, often considers that what the Judicial Review proposes is not the subject of acknowledgment. Constitutional Court Judges considered it to be a Constitutional complaint in which this constitutional complaint was not part of the Court's authority in accordance with the Constitution of the Republic of Indonesia and the applicable Law on the Understanding of the Constitution. As a legislative body, the DPR is the one who has the right to change the Constitutional Court Law by including the authority of Constitutional complaint to the Constitutional Court. In this paper the author uses a research method in the form of quality data analysis with secondary sources of literature and deductive logic analysis. Consitional Complaint to the Constitutional Court.
Creating Props: Improving Writing Skills of Teaching Materials of Elementary Teacher Education Students through Project-Based Learning Model
Authors: Wardani Duhita Savira , Fauzi Muhammad Rizal , Zafira Ruwaida , Kurniawati Dian 
Published: January 2021

This study aimed to determine the improvement in writing skills of science teaching materials for elementary school teachers students through the Project-Based Learning (PjBL) model. This study used a quasi-experimental method with One Group Pretest-Posttest Design using portfolio assessment sheets to write science teaching materials. Data were analyzed using a T-test. This study's subjects were pre-service teacher students who contracted Natural Science Learning courses in the Elementary Teacher Education Program. The study results indicated that PjBL could increase pre-service teachers' skills in developing teaching materials relevant to the 21st-century skills, students' character, and the applicable curriculum. This result is evidenced by the results of the assessment, which increased significantly from 2.04 to 3.25. It is also based on the Wilcoxon test that Asymp.Sig. (2-tailed) 0.05 which is 0.000. It means that there is an influence in the form of an increase in the PjBL model's use of the writing skills of science teaching materials for elementary teacher students. This study recommends that the PjBL model can be used as an alternative learning model to improve the writing skills of teaching materials for students.
Improvement of Creative Thinking Ability of Elementary Teacher Education Students in Utilizing Traditional Games in Social Studies Learning
Authors: Arga Hana Sakura Putu , Nurfurqon Faridillah Fahmi , Nurani Riga Zahara 
Published: January 2021

Creative thinking skills of elementary teacher education students' needs to be improved in a fun social studies learning process. One of the lessons that can make learning a pleasant atmosphere is to apply knowledge by applying traditional games. This research aims to increase the creativity of elementary teacher education students in utilizing traditional games to preserve the nation's culture. The research method used was a quasi-experimental design with a nonrandomized pretest-posttest control group. The instrument used in this study was a tablet-shaped observation instrument. This research shows that learning science by applying traditional games can improve elementary teacher education students' creative thinking skills. It can be seen from the learning outcomes of elementary teacher education students social studies using traditional games that are better than conventional learning.
Приоритеты внедрения электронных государственных сервисов по результатам опроса граждан в Санкт-Петербурге
Authors: Белый А. В. , Смирнова П. В. 
Published: January 2021

В статье приводятся результаты опроса жителей Санкт-Петербурга с целью выявления их мнения о приоритетности сервисов «умного города». В результате исследования были выявлены наиболее востребованные электронные сервисы, а
также определены факторы, влияющие на их восприятие населением. Исследование было проведено в марте 2020 года методом анкетирования по выборке, репрезентирующей население Санкт-Петербурга по полу и возрасту. Результаты
показали, что в качестве наиболее актуальных жителями Санкт-Петербурга были отмечены электронные сервисы в сфере здравоохранения и медицины (78%), сервисы
безопасного города (70%), электронные сервисы в сфере транспортного обслуживания двух типов: для пассажиров общественного транспорта (63%) и владельцев личного транспорта (61%).
Институциональные стратегии внедрения цифровых ресурсов обратной связи с населением в регионах России
Authors: Кондратенко К. С. 
Published: January 2021

Статья посвящена стратегиям внедрения цифровых каналов публичной политики в регионах РФ. Проблема исследования заключается в неравномерности внедрения ресурсов обратной связи в различных регионах РФ, при этом внедрение указанных технологий описано в паспорте федерального проекта «Цифровое государственное
управление». Основная гипотеза данной статьи заключается в том, что регионы выбирают различные стратегии внедрения каналов публичного участия, по-разному решая вопрос соотношения монополизма в данной сфере и возможностей рационального выбора при создании региональных сайтов. Какие стратегии внедрения лежат в основании институциональных матриц регионов РФ – основной вопрос данной статьи.
Evaluation of right heart functions by echocardiography and tissue Doppler imaging echocardiography in obese and non-obese patients with obstructive sleep apnea
Authors: DİKMEN Nursel , GENÇ Sebahat , AKÇAY Adnan 
Published: January 2021

Purpose: The aim of our study was to compare the right ventricular systolic and diastolic functions and pulmonary artery pressure (PAP) in obese and non-obese patients with obstructive sleep apnea syndrome (OSAS) by tissue Doppler imaging (TDI) echocardiography.
Materials and Methods: This study was conducted with 69 patients, 34 obese and 35 non-obese, diagnosed moderate or severe OSAS by an overnight polysomnographic sleep study. In all patients, LV (left ventricle) and RV (right ventricle) size, left atial (LA) and RA (right atrial) dimensions, LV and RV systolic and diastolic functions and systolic PAPs were measured by M-mode, two-dimensional analysis, color flow Doppler and TDI.
Results: RV diastolic dysfunction was detected in both groups; this impairment was significantly higher in the obese group (lateral tricuspid late diastolic myocardial annular zone velocity A'a: 0.13 ± 0.03 in non-obese patients and 0.11 ± 0.04 in obese patients). The mean systolic PAP was significantly higher in obese patients (31.2±5.6, 27.1±5.8, respectively)
Conclusion: Obstructive Sleep Apnea Syndrome increases cardiovascular morbidity and mortality. In our study,left ventricul and right ventricul diastolic dysfunction was determined by tissue Doppler imaging in patients with moderate and severe Obstructive Sleep Apnea Syndrome. Obesity contributes to this impairment regardless of Obstructive Sleep Apnea Syndrome .
Ceranib-2 inhibits HIF1-α gene expression and induces apoptosis in HepG2 cells
Authors: ÖZYURT Rumeysa , OZKURT Mete , KARADAĞ Abdullah , MERAL Cemile , ERKASAP Nılufer 
Published: January 2021

Purpose: The aim of this study is to investigate the apoptotic effect of a novel anti-cancer drug, ceranib-2 and impact on HIF-1α levels on HepG2.
Materials and Methods: The cell line was treated in vitro with 0,1, 1, 5, 10, 25 and 50 µM ceranib-2 for 24 and 48 hours and cell viabilitiy was determined. mRNA levels of acid ceramidase, caspase-3, caspase-8, caspase-9, Cyc1, HIF-1α and TNF-α were measured by qPCR.
Results: Ceranib-2 at 10 µM concentration reduced the viability by about 58 % after 24 and 48 hours. The same dose increased mRNA level of caspase-3 and no change was detected on caspase-8 when compared to the control group after 24 hours. No difference was detected on caspase-3, but caspase-8 mRNA level increased after 48 hours with ceranib-2 at 10 µM concentration. Caspase-9 mRNA levels did not differ after 24 and 48 hours. Ceranib-2 at 10 µM concentration lowered mRNA level of Cyc1 against the control group after the 24- hour treatment. ASAH mRNA level was reduced after the 48-hour treatment with 10 µM ceranib-2. Reduction of ASAH indicated that 10 µM ceranib-2 could inhibit ceramidase after 48 hours and this may elavate ceramide concentration. TNF-α mRNA increased after 24 and 48 hours, but HIF-1α expression was low after 24 hours when compared to the control group.
Conclusion: We have found that ceranib-2 induces apoptosis in HepG2, thus ceranib-2 may play an anti-cancer role at 10 µM concentration.
Determination of risk factors affecting fear of childbirth during pregnancy
Authors: SOYSAL Cenk , IŞIKALAN Mehmet Murat 
Published: January 2021

Purpose: We aimed to investigate the level of fear of childbirth in pregnant women in terms of factors such as age, number of births, education level, and immigration status.
Materials and Methods: This cross-sectional study was carried out by including 444 pregnant women who have 32-36 weeks of pregnancy and voluntarily agree to participate in the research, all of them are literate and applied to Kütahya Health Sciences University Evliya Çelebi Training and Research Hospital between 25.07.2019 - 01.11.2019. The data were collected using the Wijma Birth Expectation / Experience Scale (W-DEQ), and the questionnaire was administered to the immigrant patients by an outpatient doctor via an interpreter.
Results: The average age of the pregnant women was 31.65 ± 6.83 years. 24.8% (n = 110) of all the participants had low levels of fear of childbirth, 21.8% (n = 97) had moderate fear, 27.9% (n = 124) had severe fear, and 25% (n = 113) were identified as having very severe fear of childbirth. The W-DEQ score increased as the education level increased, but there was no difference between university graduates and postgraduate pregnant women. Fear of childbirth in migrant women was found to be significantly lower compared to Turkish women.
Conclusion: Fear of childbirth is affected by age, education, immigration, and these conditions vary among societies. Pre-determining conditions that can increase fear of childbirth and implementing social support programs in selected patient groups may decrease the fear of childbirth and lower the number of cesarean sections in Turkey.
Plastik cerrahi servisinde çalışan hemşirelerin cinsiyet değiştirme ameliyatı olan transseksüel bireylere yaklaşımı
Authors: DENİZ DOĞAN Sevgi , KARAÇAY YIKAR Seda , ATICI Meral , ARSLAN Sevban 
Published: January 2021

Amaç: Bu çalışmanın amacı, plastik cerrahi servisinde çalışan hemşirelerin cinsiyet değiştirme ameliyatı olmuş transseksüel bireylere yaklaşımlarını incelemektir.
Gereç ve Yöntem: Çalışmaya plastik cerrahi kliniğinde çalışan ve transseksüel bireylere bakım vermiş 6 hemşire alınmıştır. Araştırmada veriler nitel veri toplama yöntemlerinden görüşme yöntemi kullanılarak toplanmış ve görüşmelerden elde edilen nitel verilerin analizinde içerik analizi yöntemi kullanılmıştır.
Bulgular: Araştırmanın bulgularına göre hemşirelerin transseksüelliği, daha çok kişisel bir tercih olarak gördükleri saptanmıştır. Hemşirelerin transseksüel bireylere bakım verirken yaşadıkları güçlüklerin daha çok transseksüel bireylerin kişilik özelliklerinden kaynaklandığı saptanmış olup en sık zorlayıcı kişilik özelliklerinden dolayı güçlük yaşadıkları görülmüştür. Hemşirelerin bakım verirken yaşadıkları güçlükler için kullandıkları baş etme yöntemlerinin ise anlayışlı olma, kod adı kullanma ve hassas davranma olduğu saptanmıştır.
Sonuç: Cinsiyet değiştirme ameliyatı olan transseksüel bireylerin yaşadıkları bu zorlu süreçteki ihtiyaçlarının ve endişelerinin giderilmesi için hemşirelere önemli sorumluluklar düşmektedir. Bu bağlamda hemşirelerin bakım verirken yaşadıkları güçlüklerin belirlenmesi ve bu güçlükler ile baş etme yöntemleri geliştirebilmeleri için farklı örneklem gurupları ile çeşitli çalışmalar yapılarak hizmet içi eğitimlerin artırılması önerilebilir.
Imaging in diagnosis and management of COVID 19: A short review
Authors: Kumar D Jagadeesh , Prasad K.V Vidhi , Narayan Priya , M Govindaraju , G Nagendra H 
Published: January 2021

Since the outbreak of COVID 19 in early December 2019, the WHO has reported over 33 million cases and more than one million deaths worldwide. The Pandemic has thrown all forms of life out of gear and has transformed into a global emergency, causing widespread havoc. There is currently no treatment for the disease and early diagnosis is also becoming more challenging. This review focuses on the structure of the virus, its etiology, epidemiology with emphasis on diagnosis and imaging.The COVID 19 pandemic has thrown life out of control with the new norm. Here we review the Diagnosis of COVID with an emphasis on imaging.
Comparative evaluation of nitrate reductase assay with conventional proportion method for isoniazid and rifampicin susceptibility testing in smear positive pulmonary tuberculosis patients
Authors: Farooq Mir Rumana , Yousuf Peerzada Bushra , Samad Lubna 
Published: January 2021

With the surge of multidrug-resistant tuberculosis (MDR-TB) strains there is an escalating need for precise and cost-effective methods for a precipitous diagnostic and drug susceptibility testing (DST), chiefly in resource limited countries where tuberculosis is endemic. To find out the susceptibility pattern of Isoniazid (INH) and Rifampicin (RMP) in smear positive cases of pulmonary TB at MMIMSR Mullana and to evaluate the sensitivity and specificity of nitrate reductase assay (NRA) with standard proportion method for INH and RMP susceptibility testing. A cross sectional test validation study was carried out at Mycobacteriology division in the Department of Microbiology on 100 smear positive sputum samples from pulmonary tuberculosis patients.In comparison with L.J proportion method, NRA showed sensitivity, specificity, PPV, NPV, accuracy of 100%, 98.64%, 87.50%, 100%, and 98.76% respectively for INH. The sensitivity, specificity, PPV, NPV, accuracy of NRA compared to PM for RMP was 100%, 97.33%, 75.00%, 100%, 97.53% respectively. Direct NRA is simple, easy to perform, prompt, reasonably less expensive, without requisite of expensive reagents and advanced instrumentation. It is highly specific and sensitive technique in the detection of drug resistant TB when tested in parallel with the proportion method. Therefore, NRA may be routinely employed in TB laboratories in developing countries for drug susceptibility testing of .