bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tale of 2 Pneumos: The Impact of Human Immunodeficiency Virus Exposure or Infection Status on Pediatric Nasopharyngeal Carriage ofStreptococcus pneumoniaeandPneumocystis jiroveci: A Nested Case Control Analysis From the Pneumonia Etiology Research In Child Health Study
Authors: Camelo Ingrid Y , Mwananyanda Lawrence M , Thea Donald M , Seidenberg Philip , Gill Christopher J , Weinstein John R 
Published: March 2020

AbstractBackgroundThe majority of pediatric human immunodeficiency virus (HIV) cases in Africa reflect maternal-to-child transmission. HIV exposed but uninfected (HEU) children have increased rates of morbidity and mortality when compared to HIV unexposed and uninfected (HUU) children. The mechanisms behind these unexpected trends are only partially understood but could be explained by the differences in the immune response to infections triggered by an altered immune system state.MethodsUsing quantitative reverse transcription polymerase chain reaction, we compared the nasopharyngeal carriage prevalence and density of Streptococcus pneumoniae (SP) and Pneumocystis jirovecii (PJ) between children living with HIV and HEU or HUU cases (pneumonia) and controls (without pneumonia).ResultsThe cohort included 1154 children (555 cases and 599 matched controls). The SP carriage prevalence rates were similar between cases and controls. Among SP carriers with pneumonia, carriage density was increased among children living with HIV, versus HEU or HUU children (15.8, 4.7, and 3.6 × 105 copies/mL, respectively). The rate of PJ carriage was significantly higher among children living with HIV than among HEU and HUU children (31%, 15%, and 10%, respectively; P &lt; .05), as was carriage density (63.9, 20.9, and 4.8 × 103 copies/mL, respectively; P &lt; .05).ConclusionsCarriage prevalences and densities for SP and PJ show different kinetics in terms of their relationship with HIV exposure and clinical status, particularly for Pneumocystis jirovecii. This supports the theory that the increased morbidity and mortality observed among HEU children may reflect deficits not just in humoral immunity but in cell-mediated immunity as well.
Reduction in Baseline CD4 Count Testing Following Human Immunodeficiency Virus “Treat All” Adoption in Uganda
Authors: Nasuuna Esther , Tenforde Mark W , Muganzi Alex , Jarvis Joseph N , Manabe Yukari C , Kigozi Joanita 
Published: March 2020

Abstract
Baseline CD4 testing rates declined from 73% to 21% between 2013 and 2018 with adoption of “Treat All” in Uganda. Advanced human immunodeficiency virus (HIV) disease (CD4 count &lt; 200 cells/µL) remained common (24% of those tested in 2018, 83% of whom had World Health Organization stage I/II disease). Despite frequent presentation with advanced HIV disease, CD4 testing has declined dramatically.
Rider-Rank Algorithm-Based Feature Extraction for Re-ranking the Webpages in the Search Engine
Authors: Sankpal Lata Jaywant , Patil Suhas H 
Published: March 2020

AbstractThe webpage re-ranking is a challenging task while retrieving the webpages based on the query of the user. Even though the webpages in the search engines are ordered depends on the importance of the content, retrieving the necessary documents based on the input query is quite difficult. Hence, it is required to re-rank the webpages available in the websites based on the features of the pages in the search engines, like Google and Bing. Thus, an effective Rider-Rank algorithm is proposed to re-rank the webpages based on the Rider Optimization Algorithm (ROA). The input queries are forwarded to different search engines, and the webpages generated from the search engines with respect to the input query are gathered. Initially, the keywords are generated for the webpages. Then, the top keyword is selected, and the features are extracted from the top keyword using factor-based, text-based and rank-based features of the webpage. Finally, the webpages are re-ranked using the Rider-Rank algorithm. The performance of the proposed approach is analyzed based on the metrics, such as F-measure, recall and precision. From the analysis, it can be shown that the proposed algorithm obtains the F-measure, recall and precision of 0.90, 0.98 and 0.84, respectively.
Warmer temperature and provision of natural substrate enable earlier metamorphosis in the critically endangered Baw Baw frog
Authors: Gilbert Deon J , Magrath Michael J L , Byrne Phillip G 
Published: March 2020

Abstract
Temperature and food availability are known to independently trigger phenotypic change in ectotherms, but the interactive effects between these factors have rarely been considered. This study investigates the independent and interactive effects of water temperature and food availability on larval growth and development of the critically endangered Baw Baw frog, Philoria frosti. Larvae were reared at low (12°C) or high (17°C) water temperature in the absence or presence of substrate that controlled food availability, and body size and time to metamorphosis were quantified. Growth and development of larvae was influenced by the individual effects of temperature and food availability; time to metamorphosis was shorter in warm water treatment groups and in the presence of substrate and increased food. Unexpectedly, however, water temperature and food availability did not have an interactive effect on either time to metamorphose or body size at metamorphosis. Under all treatment groups, metamorphic onset occurred once a developmental size threshold was reached, indicating that growth rate and body size are key factors controlling the metamorphic process in Baw Baw frogs (consistent with the Wilbur–Collins model for ectotherm development). From an applied perspective, our findings have implications for amphibian conservation because they indicate that simple manipulations of temperature and food availability can be used to increase the rate of frog production in conservation breeding programs.
Cervical spinal cord injury by a low-impact trauma as an unnoticed cause of cardiorespiratory arrest
Authors: Mayà-Casalprim Gerard , Ortiz Jose , Tercero Ana , Reyes David , Iranzo Álex , Santamaria Joan , Bosch Xavier , Gaig Carles 
Published: March 2020

Abstract

Background
Cardiorespiratory arrest (CA) secondary to traumatic cervical spinal cord injury can occur in minor accidents with low-impact trauma and may be overlooked as the cause of CA in patients admitted in the coronary care unit.

Case summary
We present two patients admitted to the coronary care unit because of suspected CA of cardiac origin. Both patients were found in CA with asystole, one after collapsing in a shopping mall and falling down a few steps and the other in the street next to his bicycle. They underwent early pharmacologically induced coma and hypothermia precluding neurological examination. Both patients remained in coma after rewarming, with preserved brainstem reflexes but absent motor response to pain. One patient had post-anoxic myoclonus in the face without limb involvement. In both patients, median nerve somatosensory evoked potentials demonstrated bilateral absence of thalamocortical N19 responses and abnormal cervicomedullary junction potentials (N13 wave). Extensive diagnostic work-up did not find a cardiac cause of the CA, pulmonary thromboembolism, or intracranial haemorrhage. In both patients, cervical spinal cord injury was diagnosed incidentally 5 and 6 days after CA, when a brain magnetic resonance imaging performed to assess post-anoxic brain injuries detected spinal cord hyperintensities with fracture and luxation of the odontoid. Both patients died 11 and 8 days after CA.

Discussion
Low-impact traumatic cervical spinal cord injury should be considered in the diagnostic work-up of patients with CA of unknown cause.
Socio-Economic Standing and Social Status in Contemporary Japan: Scale Constructions and Their Applications
Authors: Fujihara Sho 
Published: March 2020

Abstract
Current debates on the conceptualization and measurement of social stratification are finding increasing value in Weber’s distinction between class and status for empirical analysis. However, aspects of Weber’s theory have yet to be sufficiently investigated. Indeed, it remains unclear whether Weber’s theory can be applied to temporally and culturally different circumstances, or whether social status is preferred to other occupational scales such as prestige or socio-economic standing. To address this gap, this study constructed a Japanese Socio-Economic Index (JSEI) and a Japanese Social Status Index (JSSI), using data from the Employment Status Survey conducted in 2007 and 2012. We applied these two indexes to analyses of social stratification in Japan, finding that the JSEI and JSSI worked better in the intergenerational inheritance of occupational status than the Japanese occupational prestige scale. We also found that the JSSI was useful for predicting the cultural activities of individuals—as Weber predicted. The JSEI and JSSI showed results similar to those found in European societies and so demonstrated their validity and usefulness for investigating social stratification in Japan, thereby extending European findings on social stratification into an Asian society.
Oral caffeine intake amplifies the effect of isoproterenol in patients with frequent premature ventricular contractions
Authors: Hasebe Hideyuki , Yoshida Kentaro , Furuyashiki Yoshitaka , Nogami Akihiko , Ieda Masaki 
Published: March 2020

Abstract

Aims
Infrequent appearance and failed induction of premature ventricular contractions (PVCs) at catheter ablation make their localization difficult and are associated with a poor procedural outcome. This study aimed to assess the effect of preprocedural oral caffeine intake on induction of PVCs during catheter ablation.

Methods and results
Seventy patients (age: 54 ± 14 years, 37 men) undergoing catheter ablation for monofocal PVCs were randomized to receive oral caffeine (5 mg/kg) or placebo. Before ablation, PVC counts for 5 min were performed at baseline and during isoproterenol infusion and the isoproterenol washout period. PVC count fluctuation was defined as the difference between the highest and lowest 5-min count among the three-time periods. The 5-min PVC counts during baseline and isoproterenol infusion were equivalent between the groups. However, those during the isoproterenol washout period and PVC count fluctuation were significantly higher in the caffeine group than the control group (73.1 ± 73.2 vs. 38.9 ± 28.9 beats/5 min, P = 0.012 and 69.3 ± 61.3 vs. 37.7 ± 30.9 beats/5 min, P = 0.008, respectively). The procedure and ablation times were significantly shorter in the caffeine group than the control group (105.0 ± 23.4 vs. 136.9 ± 43.2 min, P &lt; 0.01 and 219.1 ± 104.7 vs. 283.5 ± 136.0 sec, P &lt; 0.01, respectively).

Conclusion
Oral caffeine intake amplified the effect of isoproterenol infusion on PVC induction during catheter ablation. The combined use of oral caffeine intake and isoproterenol infusion can be an option to increase intraprocedural PVCs.
Assessing guideline-concordant care for patients with multimorbidity treated in a care management setting
Authors: Cohen-Stavi Chandra J , Key Calanit , Giveon Shmuel , Molcho Tchiya , Balicer Ran D , Shadmi Efrat 
Published: March 2020

AbstractBackgroundDisease-specific guidelines are not aligned with multimorbidity care complexity. Meeting all guideline-recommended care for multimorbid patients has been estimated but not demonstrated across multiple guidelines.ObjectiveMeasure guideline-concordant care for patients with multimorbidity; assess in what types of care and by whom (clinician or patient) deviation from guidelines occurs and evaluate whether patient characteristics are associated with concordance.MethodsA retrospective cohort study of care received over 1 year, conducted across 11 primary care clinics within the context of multimorbidity-focused care management program. Patients were aged 45+ years with more than two common chronic conditions and were sampled based on either being new (≤6 months) or veteran to the program (≥1 year).MeasuresThree guideline concordance measures were calculated for each patient out of 44 potential guideline-recommended care processes for nine chronic conditions: overall score; referral score (proportion of guideline-recommended care referred) and patient-only score (proportion of referred care completed by patients). Guideline concordance was stratified by care type.Results4386 care processes evaluated among 204 patients, mean age = 72.3 years (standard deviation = 9.7). Overall, 79.2% of care was guideline concordant, 87.6% was referred according to guidelines and patients followed 91.4% of referred care. Guideline-concordant care varied across care types. Age, morbidity burden and whether patients were new or veteran to the program were associated with guideline concordance.ConclusionsPatients with multimorbidity do not receive ~20% of guideline recommendations, mostly due to clinicians not referring care. Determining the types of care for which the greatest deviation from guidelines exists can inform the tailoring of care for multimorbidity patients.
Characterization of a butyrate kinase from Desulfovibrio vulgaris str. Hildenborough
Authors: Bachochin Maxwell J , Venegas Jessica Castillo , Singh Gundeep , Zhang Liyang , Barber Robert D 
Published: March 2020

ABSTRACT
Short and branched chain fatty acid kinases participate in both bacterial anabolic and catabolic processes, including fermentation, through the reversible, ATP-dependent synthesis of acyl phosphates. This study reports biochemical properties of a predicted butyrate kinase from Desulfovibrio vulgaris str. Hildenborough (DvBuk) expressed heterologously and purified from Escherichia coli. Gel filtration chromatography indicates purified DvBuk is active as a dimer. The optimum temperature and pH for DvBuk activity is 44°C and 7.5, respectively. The enzyme displays enhanced thermal stability in the presence of substrates as observed for similar enzymes. Measurement of kcat and KM for various substrates reveals DvBuk exhibits the highest catalytic efficiencies for butyrate, valerate and isobutyrate. In particular, these measurements reveal this enzyme's apparent high affinity for C4 fatty acids relative to other butyrate kinases. These results have implications on structure and function relationships within the ASKHA superfamily of phosphotransferases, particularly regarding the acyl binding pocket, as well as potential physiological roles for this enzyme in Desulfovibrio vulgaris str. Hildenborough.
Effect of post-ruminal guanidinoacetic acid supplementation on creatine synthesis and plasma homocysteine concentrations in cattle
Authors: Ardalan Mehrnaz , Batista Erick D , Titgemeyer Evan C 
Published: March 2020

AbstractCreatine stores high-energy phosphate bonds in muscle, which is critical for muscle activity. In animals, creatine is synthesized in the liver from guanidinoacetic acid (GAA) with methylation by S-adenosylmethionine. Because methyl groups are used for the conversion of GAA to creatine, methyl group deficiency may occur as a result of GAA supplementation. With this study, the metabolic responses of cattle to post-ruminal supplementation of GAA were evaluated with and without methionine (Met) supplementation as a source of methyl groups. Six ruminally cannulated Holstein heifers (520 kg) were used in a split-plot design with treatments arranged as a 2 × 5 factorial. The main plot treatments were 0 or 12 g/d of l-Met arranged in a completely randomized design; three heifers received each main plot treatment throughout the entire experiment. Subplot treatments were 0, 10, 20, 30, and 40 g/d of GAA, with GAA treatments provided in sequence from lowest to highest over five 6-d periods. Treatments were infused continuously to the abomasum. Heifers were limit-fed twice daily a diet consisting of (dry matter basis) 5.3 kg/d rolled corn, 3.6 kg/d alfalfa hay, and 50 g/d trace-mineralized salt. Plasma Met increased (P &lt; 0.01) when Met was supplemented, but it was not affected by supplemental GAA. Supplementing GAA linearly increased plasma arginine (% of total amino acids) and plasma concentrations of GAA and creatinine (P &lt; 0.001). Plasma creatine was increased at all levels of GAA except when 40 g/d of GAA was supplemented with no Met (GAA-quadratic × Met, P = 0.07). Plasma homocysteine was not affected by GAA supplementation when heifers received 12 g/d Met, but it was increased when 30 or 40 g/d of GAA was supplemented without Met (GAA-linear × Met, P = 0.003); increases were modest and did not suggest a dangerous hyperhomocysteinemia. Urinary concentrations of GAA and creatine were increased by all levels of GAA when 12 g/d Met was supplemented; increasing GAA supplementation up to 30 g/d without Met increased urinary GAA and creatine concentrations, but 40 g/d GAA did not affect urine concentrations of GAA and creatine when no Met was supplemented. Overall, post-ruminal GAA supplementation increased creatine supply to cattle. A methyl group deficiency, demonstrated by modest increases in plasma homocysteine, became apparent when 30 or 40 g/d of GAA was supplemented, but it was ameliorated by 12 g/d Met.
Noblemen, Spies, and a Hindu Monk Going to War: Notes on Swami B. H. Bon in New York, 1940–41
Authors: Broo Måns 
Published: March 2020

AbstractBased on previously classified material from the India Office, London, this article looks at the wartime correspondence generated by the offer of Gaudiya Vaishnava missionary Swami B. H. Bon (1901–82), at this time working in New York, to volunteer as a ‘Hindu chaplain’ in the fight against Nazi Germany. Combining this material with media reports and reminiscences, this article not only sheds light on a period in the life on Swami Bon that is little known, but also illuminates some of the hopes and anxieties of the last years of British colonial rule over India.
Potential female mate choice in a male dominated system: the female capybara, Hydrochoerus hydrochaeris
Authors: Bedoya-Pérez Miguel A , Herrera Emilio A , Congdon Elizabeth R 
Published: March 2020

AbstractCapybaras, Hydrochoerus hydrochaeris (Rodentia: Caviidae: Hydrochoerinae), show a strict social hierarchy among males, wherein the top-ranking male gains preferential access to females. Despite minimal sexual size dimorphism, males have a prominent scent gland on their snouts that is greatly reduced in the females. Top-ranking males have a larger gland and mark more frequently than subordinate males. This species also shows a moderately complex courtship that seems to be modulated by female behavior. In this study, we evaluated several components of courtship, as well as the females’ interactions with males during and outside courtship, in relation to the hierarchy rank of males. We found that subordinate males engaged in longer courtships than top-ranking males. However, there was no difference in the number of mount attempts or the success rate of these mounts as a function of the social status of the male, despite the longer courtship performed by subordinate males in comparison to top-ranking males. Outside courtship, females directed the same number of social interactions to males regardless of status. However, during courtship, females avoided copulation by subordinate males both directly and indirectly by encouraging courtship disruption by higher-ranking males. Females’ avoidance of subordinates may force these males to invest a higher amount of effort in courtships, thus engaging in longer courtships, yet achieving similar mount success as top-ranking males. We show that the original assumption of male hierarchy as the main mechanism of reproductive distribution is incomplete, and female mate choice plays an important role in determining which males reproduce.
High-resolution spectroscopy of red giants and ‘yellow stragglers’ in the southern open cluster NGC 2539
Authors: Martinez Cintia F , Holanda N , Pereira C B , Drake N A 
Published: March 2020

ABSTRACT
We present a detailed high-resolution spectroscopic analysis of 12 red giant stars, in single and binaries or multiples systems, classified as members of the intermediate-age (631 Myr) open cluster NGC 2539. We used FEROS echelle spectra and the standard LTE analysis to derive the atmospheric parameters for the stars and the abundance ratios of light elements (Li, C, N), light odd-Z elements (Na, Al), α-elements (Mg, Si, Ca, Ti), Fe-group elements (Cr, Fe, Ni), and n-capture elements (Y, Zr, Ce, Nd, Eu). Our results show that the sample star of NGC 2539 has low projected rotational velocities and an almost solar metallicity, with a mean of [Fe/H] = −0.03 ± 0.07 dex. The abundance pattern displays for the analyzed stars are, in general, similar to those presented by solar neighborhood stars, including giant members of others open clusters. In particular, light elements and Na abundance pattern shows anomalies resulting from the appearance of enriched material on the stellar surface, produced by mechanisms like the first dredge-up and/or thermohaline and rotation-induced mixing. We also identified two of the spectroscopic binaries of our sample as ‘yellow stragglers’ and we determined the nature of their companions.
RNAi pathways repress reprogramming of C. elegans germ cells during heat stress
Authors: Rogers Alicia K , Phillips Carolyn M 
Published: March 2020

AbstractRepression of cellular reprogramming in germ cells is critical to maintaining cell fate and fertility. When germ cells mis-express somatic genes they can be directly converted into other cell types, resulting in loss of totipotency and reproductive potential. Identifying the molecular mechanisms that coordinate these cell fate decisions is an active area of investigation. Here we show that RNAi pathways play a key role in maintaining germline gene expression and totipotency after heat stress. By examining transcriptional changes that occur in mut-16 mutants, lacking a key protein in the RNAi pathway, at elevated temperature we found that genes normally expressed in the soma are mis-expressed in germ cells. Furthermore, these genes displayed increased chromatin accessibility in the germlines of mut-16 mutants at elevated temperature. These findings indicate that the RNAi pathway plays a key role in preventing aberrant expression of somatic genes in the germline during heat stress. This regulation occurs in part through the maintenance of germline chromatin, likely acting through the nuclear RNAi pathway. Identification of new pathways governing germ cell reprogramming is critical to understanding how cells maintain proper gene expression and may provide key insights into how cell identity is lost in some germ cell tumors.