bluuebunny/crossref_metadata_2025_split huggingface dataset:
Site‐specific metastasis: A cooperation between cancer cells and the metastatic microenvironment
Authors: Izraely Sivan , Witz Isaac P. 
Published: August 2020

AbstractThe conclusion derived from the information provided in this review is that disseminating tumor cells (DTC) collaborate with the microenvironment of a future metastatic organ site in the establishment of organ‐specific metastasis. We review the basic principles of site‐specific metastasis and the contribution of the cross talk between DTC and the microenvironment of metastatic sites (metastatic microenvironment [MME]) to the establishment of the organ‐specific premetastatic niche; the targeted migration of DTC to the endothelium of the future organ‐specific metastasis; the transmigration of DTC to this site and the seeding and colonization of DTC in their future MME. We also discuss the role played by DTC‐MME interactions on tumor dormancy and on the differential response of tumor cells residing in different MMEs to antitumor therapy. Finally, we summarize some studies dealing with the effects of the MME on a unique site‐specific metastasis—brain metastasis.
The dividends behaviour of the Jordanian companies listed in Amman Stock Exchange: Three essays
Authors: Alrabadi Dima W. H. , Al‐Hallaq Said S. , Abu‐Alkhair Abdullah S. 
Published: August 2020

AbstractThis study investigates the dividend behaviour of the Jordanian companies listed in Amman Stock Exchange. In specific, it examines whether dividends policy differs according to firm size, whether it differs for diverse sectors and whether it is stable over time. The sample of the study consists of 90 Jordanian companies listed in Amman Stock Exchange (ASE), 30 companies from each sector: financial, services and industrial, with 990 observations of dividends per share (DPS), earnings per share (EPS) and market capitalization (MC) over the period (2006–2016).The study uses non‐parametric tests in addition to regression analysis. Results show that there are statistically significant differences between DPS in the three sectors (financial, industrial and services). Statistically significant differences in DPS between different sized companies in the three sectors (financial, industrial and services) in ASE are also found. The dividends are stable over time.
Social engagement, self‐efficacy, and posttraumatic stress symptoms across 6 months of psychotherapy
Authors: Shoji Kotaro , Smith Andrew J. , Sano Riko , Samuelson Kristin W. , Benight Charles C. 
Published: August 2020

AbstractObjectiveThe current study was conducted in a naturalistic treatment setting to examine whether and how perceptions about social engagement, trauma coping self‐efficacy, and posttraumatic stress symptoms (PTS) influence one another across 6 months of psychotherapy for trauma survivors.MethodThe sample included 183 clients who reported exposure to traumatic events and significant PTS (PCL‐5 ≥ 33). Participants (Mage = 37.8, 53.6% female) completed surveys at intake, 3 months, and 6 months into treatment. A cross‐lagged panel analysis was used to test the relationships among perceived social engagement, coping self‐efficacy, and PTS across three assessment points.ResultsPTS at 3‐months was a mediator in the relationship between intake perceived social engagement and 6‐month coping self‐efficacy and between intake perceived social engagement and 6‐month perceived social engagement.ConclusionsPTS several months into treatment may serve as a mechanism between intake perceived social engagement and functional outcomes such as coping self‐efficacy.
Designing a biocatalytic process involving deep eutectic solvents
Authors: Panić Manuela , Cvjetko Bubalo Marina , Radojčić Redovniković Ivana 
Published: August 2020

AbstractDuring the last decade, deep eutectic solvents (DESs) have emerged as a promising alternative to traditional organic solvents, from both environmental and technological perspectives. The number of structural combinations encompassed by DESs is tremendous; thus, it is possible to design an optimal DES for each specific enzymatic reaction system. In (bio)catalytic processes, a DES can serve as solvent/co‐solvent, as an extractive reagent for an enzymatic product, and as a pretreatment solvent of enzymatic biomass. To date, hydrolases are the most studied enzymes in DESs, which is not surprising given that lipases are the most important industrial enzymes. At the same time, there are a limited number of papers dealing with synthetic reactions in DESs involving other hydrolytic enzymes (epoxide hydrolases, phospholipase, proteases and haloalkane dehalogenases), lyases, and dehydrogenases (as a part of the whole Saccharomyces cerevisae and Escherichia coli cell biocatalysis). When designing efficient biocatalytic processes involving DESs, independent of the reaction type and enzyme used, the following steps should be included: (i) preparation and characterisation of the DES, (ii) screening of the DES for optimal enzyme performance, (iii) selection and optimisation of the biocatalytic protocol, and (iv) recovery of the product/DES and DES recycling with possible scale‐up. In this paper, we will present some practical aspects that we experienced while working with these solvents, together with some major observations that are available in the literature. © 2020 Society of Chemical Industry
Design, synthesis, and bioactivities of novel pyridazinone derivatives containing 2‐phenylthiazole or oxazole skeletons
Authors: Dang Mingming , Liu Minhua , Huang Lu , Ou Xiaoming , Long Chuyun , Liu Xingping , Ren Yeguo , Zhang Ping , Huang Mingzhi , Liu Aiping 
Published: August 2020

AbstractA series of novel pyridazinone derivatives were designed and synthesized by replacing 4‐(tert‐butyl)phenyl moiety of pyridaben with 2‐phenylthiazole or oxazole fragments via activity substructure connecting approach. The structures of all target compounds were characterized through NMR, MS, and elemental analysis. Bioassay results exhibit that most compounds showed potent bioactivities against Aphis fabae, Tetranychus urticae, Erysiphe graminis, and/or Puccinia polysora. Among the newly synthesized compounds, 2‐(tert‐butyl)‐4‐chloro‐5‐(((2‐phenylthiazol‐4‐yl)methyl)thio)pyridazin‐3(2H)‐one (12b) displays remarkable insecticidal activity against A fabae. Its LC50 value (2.73 mg/L) is better than that of pyridaben (5.46 mg/L), although inferior to that of imidacloprid (0.51 mg/L). In addition to its extraordinary insecticidal activity, compound 12b also exerts 96.9% fungicidal activities against P polysora at 500 mg/L in vivo, significantly superior to that of pyridaben (50.0%), while slightly lower than that of tebuconazole (100%). This article discusses the synthesis, bioassay results, and structure‐activity relationship of this series of novel pyridazinone derivatives.
Mannose phosphate isomerase deficiency‐congenital disorder of glycosylation (MPI‐CDG) with cerebral venous sinus thrombosis as first and only presenting symptom: A rare but treatable cause of thrombophilia
Authors: Mühlhausen Chris , Henneke Lisa , Schlotawa Lars , Behme Daniel , Grüneberg Marianne , Gärtner Jutta , Marquardt Thorsten 
Published: August 2020

AbstractMannose phosphate isomerase deficiency‐congenital disorder of glycosylation (MPI‐CDG; formerly named CDG type 1b) is characterized by the clinical triad of hepatopathy, protein‐losing enteropathy, and hyperinsulinemic hypoglycemia in combination with coagulation disorder (thrombophilia, depletion of antithrombin, proteins C and S, factor XI). In the majority of patients, MPI‐CDG manifests during early infancy or childhood. Here, we present a 15‐year‐old female patient with unremarkable medical history suffering from acute cerebral venous sinus thrombosis necessitating interventional thrombectomy and neurosurgical decompression. Diagnostic work‐up of thrombophilia revealed deficiency of antithrombin (AT), proteins C and S, and factor XI. Detailed evaluation identified MPI‐CDG as the underlying cause of disease. After initiation of mannose therapy, coagulation parameters normalized. The girl fully recovered without any neurologic sequelae, and remains free of further thrombotic events or any other clinical and laboratory abnormalities on follow‐up 1 year after start of mannose treatment. In conclusion, we here present the significant case of MPI‐CDG with a severe cerebral venous sinus thrombosis as the first and only symptom of the disease. In light of the high frequency of AT deficiency on one hand, and the excellent treatability of MPI‐CDG on the other hand, CDG screening should be included as a routine analysis in all patients presenting with unexplained coagulation disorder, especially when comprising AT deficiency.
Multiexponential Analysis of the Water T2‐Relaxation in the Skeletal Muscle Provides Distinct Markers of Disease Activity Between Inflammatory and Dystrophic Myopathies
Authors: Araujo Ericky C. A. , Marty Benjamin , Carlier Pierre G. , Baudin Pierre‐Yves , Reyngoudt Harmen 
Published: August 2020

BackgroundThe monoexponential water T2 (T2‐mono) is a proven biomarker of disease activity in neuromuscular disorders (NMDs). However, it lacks specificity, being elevated in the presence of several pathological processes and pathomorphological alterations in the muscle tissue.PurposeTo investigate the multiexponential behavior of the water T2‐relaxation in the skeletal muscle of NMD patients, aiming to identify more sensitive and specific biomarkers of disease activity.Study TypeRetrospective case–control.PopulationThirty Duchenne muscular dystrophy and 114 inclusion body myositis patients and 55 control subjects.Field Strength/Sequence3T/Single‐voxel proton spectroscopy (1H‐MRS) and multispin‐echo (MSE) imaging.AssessmentWater T2‐decay curves generated from 1H‐MRS data acquired at 14 echo‐times were fitted to mono‐ and biexponential models and the adjusted R2 of each fit was computed. Additionally, T2 spectra were generated from a regularized inverse Laplace transform. For comparison, water T2 maps were generated from the MSE data. The performances of the different variables at identifying patients were assessed via receiver operating characteristic (ROC)‐curve analysis.Statistical TestsChi‐square, Kruskal–Wallis, and Mann–Whitney with Bonferroni correction for multiple comparisons.ResultsT2‐mono was elevated in patients (P<0.05), but could not distinguish inclusion body myositis (IBM) from Duchenne muscular dystrophy (DMD). While 79% of IBM data presented a biexponential behavior, this was only 16% and 10% for DMD and control data, respectively (P<0.05). All T2 spectra presented an intermediate‐T2 peak characterized by an elevated T2 in patients (P<0.05) and by a relative fraction that was abnormally smaller in IBM patients (P<0.05). Also, a long‐T2 peak was exclusively observed in IBM patients. A combination of T2‐spectrum variables performed best at identifying patients.Data ConclusionT2 spectra not only provided more sensitive and specific markers of disease presence than the T2‐mono, but also allowed distinguishing IBM from DMD patients. This must reflect distinct predominant pathological alterations between these diseases, suggesting that these markers provide additional pathophysiological/histopathological information that are missing from T2‐mono.Level of Evidence3Technical Efficacy Stage3
Dynamics of meteorological time series on the base of ground measurements and retrospective data from MERRA‐2 for Poland
Authors: Gos Magdalena , Baranowski Piotr , Krzyszczak Jaromir , Kieliszek Adam , Siwek Krzysztof 
Published: August 2020

AbstractA comparison study has been performed to assess the dynamics of meteorological processes in Poland on the basis of meteorological time series of air pressure, air temperature and wind speed coming from 35 synoptic stations belonging to the Institute of Meteorology and Water Management—National Research Institute (IMGW‐PIB) and from the nearest grid points of the Modern‐Era Retrospective Analysis for Research and Applications, Version 2 (MERRA‐2) produced at NASA's Global Modelling and Assimilation Office from January 1, 2007 to October 31, 2016. Apart from comparative statistics, the differences in the multifractal properties of the time series were evaluated with the use of MultiFractal Detrended Fluctuation Analysis (MFDFA), both for hourly and daily data, showing a high degree of similarity between the MERRA‐2 and IMGW‐PIB series. For the air pressure and air temperature, not only were high determination coefficients (close to .99) between the time series coming from the two sources noticed, but there were also similarities with the MFDFA parameters. Lower correlations between the time series of the wind speed obtained from the two studied databases were observed, which was related to differences in the data structure and methodology of the measurements for specific IMGW‐PIB stations. Additionally, to verify data similarities coming from the IMGW‐PIB and MERRA‐2 databases, the correlations between specific multifractal parameters and the orography were estimated and compared. For the air pressure and temperature, a remarkably high correlation was found between the multifractal parameter α0 and the height above sea level of the measurement site. An analysis of the source of multifractality was performed, indicating that, for all studied meteorological elements and both data sources, the long‐range correlations prevail.
The “sufficient cause” model framework applied to the periodontitis‐systemic diseases link
Authors: Akinkugbe Aderonke A. , Papapanou Panos N. 
Published: August 2020

AbstractThe premise for the oral‐systemic diseases relationship dates to the early 20th century with the introduction of the focal infection theory that posited that oral disease affects overall health and wellbeing. While the biological plausibility for the link has been supported by experimental animal models and observational studies in humans, findings from interventional studies in which periodontal therapy failed to alleviate systemic health outcomes have often been interpreted as evidence against periodontitis contribution to the etiology of systemic health conditions. One concept of causation assumes a one‐to‐one correspondence between cause and effect. Nevertheless, common chronic diseases to which periodontitis is associated have multifactorial etiologies. This commentary provides an overview of Rothman's “sufficient cause” model as a framework for consideration of the oral‐systemic diseases link.
Topical phenytoin effects on palatal wound healing
Authors: Doshi Anuja , McAuley James W. , Tatakis Dimitris N. 
Published: August 2020

AbstractBackgroundThe clinical benefits of autogenous soft tissue grafts are countered by donor site morbidity. The aim of this prospective split‐mouth clinical trial is to assess clinical, histological and patient outcomes following topical phenytoin (PHT) treatment of experimental palatal wounds.MethodsSystemically healthy adults were recruited. One 6 mm diameter wound (posterior) and one 4 mm diameter wound (anterior), each 1‐1.5 mm deep, were created on both sides of the palate. Wounds on one randomly chosen side received 10% phenytoin USP and contralateral wounds received carrier alone. Biopsies were harvested from anterior wounds (Day 1 or Day 5) and were routinely processed for histology. Posterior wounds were left undisturbed to clinically evaluate healing (using photographs and Healing Score Index) on Days 1, 5, 14, and 21. Questionnaires were used to assess patient‐centered outcomes. Data analysis was performed using generalized logistic and generalized linear mixed models.ResultsTwenty participants completed all visits. 30% of participants reported more pain on control side than the PHT side at Day 1 (P = 0.014). PHT treated sites were more likely to not exhibit swelling (OR = 9.35; P = 0.009) and to not experience pain on palpation (OR = 6.278; P = 0.007). PHT significantly and time‐dependently affected granulation tissue appearance (P = 0.004). Histologically, there were no significant differences between control and PHT, at any time point (P ≥ 0.853).ConclusionsThe results of the present study, the first one to report on topical PHT as palatal wound treatment, suggest that PHT application on palatal wounds could result in improved healing outcomes.
Chinese girlfriend getaway tourism in Buddhist destinations: Towards the construction of a gendered spirituality dimension
Authors: Zhang Yang , Shi Kai‐Xin , Lee Timothy J. 
Published: August 2020

AbstractThis study identifies the multidimensional scale of spiritual tourism among Chinese girlfriend getaway (GGA) tourists. The 379 questionnaires were distributed using convenience sampling at Wutai Mountain, one of the most important Buddhist sites in China. Through factor analysis and structural modeling, a six‐factor model that includes escapism, leisureliness, happiness, personal enrichment, nothingness, and sense of connection (27 items) is developed and validated. Using Buddhist destinations, the study discusses GGA tourism from the spiritual point of view and reveals the significance of this experience. Implications and limitations for theory and practice as well as directions for future research are discussed.
Hexyl gallate for the control of citrus canker caused by Xanthomonas citri subsp citri
Authors: Cavalca Lúcia B. , Zamuner Caio F. C. , Saldanha Luiz L. , Polaquini Carlos R. , Regasini Luis O. , Behlau Franklin , Ferreira Henrique 
Published: August 2020

AbstractBrazil is the biggest producer of sweet oranges and the main exporter of concentrated orange juice in the world. Among the diseases that affect citriculture, Asiatic citrus canker, caused by the bacterial pathogen Xanthomonas citri, represents one of the most significant threats. The current Brazilian legislation regulating the control of citrus canker no longer requires the eradication of affected trees in states where the incidence of the disease is high. Instead, control involves disease control measures, including periodic preventative spraying of copper compounds. The long‐term use of copper for plant disease control has raised concerns about environmental accumulation and toxicity, as well as the selective pressure it exerts leading to the emergence of copper‐resistant X. citri strains. Here, we evaluated hexyl gallate (G6) as an alternative to copper compounds for citrus plant protection. G6 was able to protect citrus nursery trees against X. citri infection. Thirty days after inoculation, the trees treated with G6 developed 0.5 lesions/cm2 leaf area compared with the 2.84 lesions/cm2 observed in the untreated control trees. Also, G6 did not interfere with germination and root development of tomato, lettuce, and arugula, which is consistent with our previous data showing that G6 is safe for tissue culture cell lines. Membrane permeability tests showed that the primary target of G6 is the bacterial outer membrane. Finally, we could not isolate spontaneous X. citri mutants resistant to G6 nor induce resistance to G6 after long‐term exposures to increasing concentrations of the compound, which suggests that G6 may have multiple cellular targets. This study demonstrated that G6 is a promising candidate for the development and use in citrus canker management.
Aneurysmal bone cyst inadvertently treated with chemotherapy—A series of three cases
Authors: Deventer Niklas , Deventer Nils , Gosheger Georg , Budny Tymoteusz , de Vaal Marieke , Riegel Arne , Heitkoetter Birthe , Kessler Torsten , Poeppelmann Monika , Rossig Claudia , Juergens Heribert , Luebben Timo 
Published: August 2020

AbstractAneurysmal bone cyst (ABC) is a benign locally aggressive tumor that occurs in childhood and early adulthood. Most relevant differential diagnoses are the telangiectatic osteosarcoma and the giant cell tumor. In the present case series chemotherapy following the EURAMOS or the Euro‐Ewing 99 protocol was externally applied in three patients with the misdiagnosis of ABC as malignant bone tumor. In all three cases, a significant reduction of the volume of the ABC was achieved. This is the first report about the use of neoadjuvant chemotherapy in ABC. Chemotherapy reduces the size of an ABC and leads to progressive sclerosis.
Investigation of surface‐pegylated nanocellulose as reinforcing agent on PBAT biodegradable nanocomposites
Authors: de Souza Alana Gabrieli , de Lima Giovanni Floriano , Rangari Vijaya Kumar , dos Santos Rosa Derval 
Published: August 2020

AbstractIn the present work, nanocellulose (NC) has been surface‐pegylated and further employed as reinforcement in poly(butylene adipate‐co‐terephthalate) (PBAT) through the melting process. The nanocomposites showed a significant stiffness increase, especially the 2% pegylated‐NC, due to the good interaction between the modified NC and the matrix. Also the pegylation improved the filler‐PBAT adhesion, which resulted in higher thermal stability and low crystallinity. Raman spectroscopy confirmed the strong interaction between the 2% pegylated‐NC, morphological analysis confirmed the filler adhesion. The water absorption indicated that the pegylated‐NC has a low tendency to absorb water, which improves its applicability, for example, as a packaging material. This unique study is of great value for the future design of pegylated‐NC biodegradable nanocomposites with tailored properties.
The quality of wild Salvia miltiorrhiza from Dao Di area in China and its correlation with soil parameters and climate factors
Authors: Liang Hongyan , Kong Yuhua , Chen Wei , Wang Xiaoguo , Jia Zhenfang , Dai Yuhua , Yang Xitian 
Published: August 2020

AbstractIntroductionSalvia miltiorrhiza is a frequently used herb in traditional Chinese medicine, and tanshinone IIA (Tan IIA) and salvianolic acid B (Sal Acid B) are two major extracts obtained from its dried root. The quality of herbal ingredients can be affected by environmental factors.ObjectiveTo evaluate the quality of wild S. miltiorrhiza and investigate the influence of soil constituents and parameters as well as climatic conditions and factors on the content of Tan IIA and Sal Acid B.MethodologyWe collected samples in 12 natural locations in the Dao Di area in China, the area in which S. miltiorrhiza grows, that results in a distinctive higher quality of medicinal materials from the harvested plant. The concentrations of Tan IIA and Sal Acid B were measured by high‐performance liquid chromatography (HPLC). Soil total carbon, total nitrogen, available nitrogen, available phosphorus, available potassium, and particle size distribution were determined. We also collected climate data using ArcGIS from the WorldClim database, and correlation tests, redundancy, and regression analyses were conducted to analyse the relationship and cluster the samples according to their chemical profile.ResultsThe content of Tan IIA and Sal Acid B in most of the samples was significantly different (P < 0.05). Soil available phosphorus was considered as a key factor that influenced the quality of wild S. miltiorrhiza, and we found a significant negative association between the concentration of Tan IIA in roots and soil available phosphorus. Moreover, the accumulation of Tan IIA in S. miltiorrhiza was also significantly associated with precipitation in April, May, and October, maximum temperature in January, and standard deviation of temperature seasonality. There was no significant correlation between the content of Sal Acid B and ecological factors. In addition, samples collected from Mengshan, Hexian, and Lushi locations were rich in Tan IIA and tended to cluster together, whereas samples collected from Longquan and Huoshan locations tended to cluster and were poor in Tan IIA.ConclusionThe Tan IIA content in samples collected from southern Anhui was significantly lower than that in other Dao Di locations. The content of Tan IIA was related more to the soil than the temperature. Compared with Tan IIA, Sal Acid B was less influenced by soil and climate factors. The findings of this study may provide helpful references for quality control of medicinal plants that exert pharmacological effects in humans.