bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of acromial morphometry in the development of acromial stress fracture following reverse total shoulder arthroplasty
Authors: Yeazell Shawn T , Malige Ajith , Visser Timothy , Carolan Gregory F 
Published: March 2020

Background Indications for reverse total shoulder arthroplasty are expanding, and postoperative acromial stress fractures are a troubling postoperative complication. The purpose of this study was to determine if differences in acromial morphometry were present between cohorts with and without this complication. Methods A retrospective review of 101 reverse total shoulder arthroplasty procedures met criteria for the study. A total of eight acromial measurements on preoperative computed tomography scans were performed in axial, coronal, and sagittal views. Postoperative acromial stress fractures were confirmed by computed tomography scan on six patients and classified by fracture type. Statistical analysis was performed using a Mann–Whitney U test. Results The median acromial thickness at the posterior and lateral half was significantly thinner in the fracture cohort compared to the non-fracture cohort. Fracture and non-fracture cohort measurements demonstrated a median lateral thickness of 6.8 and 8.7 mm (p = 0.010), respectively, and median posterior thickness of 7.6 and 9.5 mm (p = 0.008), respectively. There were no demographic differences between cohorts. Discussion Two acromial measurements (lateral and posterior thickness) were associated with the development of postoperative acromial stress fracture following reverse total shoulder arthroplasty. These findings suggest that a thinner acromion in the lateral and posterior half is a risk factor for an acromial stress fracture following reverse total shoulder arthroplasty.
Lameness, generalised myopathy and myalgia in an adult cat with toxoplasmosis
Authors: Butts Daniel R , Langley-Hobbs Sorrel J 
Published: March 2020

Case summary A 2-year-old female neutered domestic shorthair cat presented with an 18-month history of intermittent lameness on all four limbs. The cat was markedly lame on all four limbs. There was alternation between toe-walking on the forelimbs with a hunched posture and using the dorsal aspect of the carpi to walk on. The cat would hiss repeatedly when walking and would lie down tentatively, appearing happier and less painful when lying. When not lying, the cat preferred to sit back on the hindlimbs and non-weightbear on the forelimbs (the so-called kangaroo stance). Physical examination detected pain on palpation of the calcaneus bone and Achilles tendon bilaterally, and general resentment to handling. Investigations revealed an elevated creatine kinase, a positive Toxoplasma gondii IgG titre, toxic neutrophilic inflammation within the Achilles tendon bursae, electromyography and nerve conduction velocity studies consistent with a diffuse muscular disease, and histopathology of the muscle consistent with a chronic and diffuse myopathy. Arthrocentesis samples and an antinuclear antibodies titre were normal. Prior treatment with meloxicam had been ineffective. A 6-week course of clindamycin was prescribed; an improvement was seen within 3 days and clinical resolution at 3 months. The cat remained clinically normal after 20 months. Relevance and novel information To our knowledge, there have been no previously published reports of histopathologically confirmed myopathy as a result of T gondii in cats. This report suggests toxoplasmosis should be considered as a differential diagnosis in cats with myopathies or lameness in the absence of other causes.
Are Patient-Reported Outcomes of Minimally Invasive Transforaminal Lumbar Interbody Fusion Influenced by Preoperative Mental Health?
Authors: Goh Graham S. , Liow Ming Han Lincoln , Yue Wai-Mun , Tan Seang-Beng , Chen John Li-Tat 
Published: March 2020

Study design: This was a retrospective review of prospectively collected data. Objectives: Few studies have described the relationship between mental health and patient-reported outcome measures (PROMs) after minimally invasive spine surgery. Prior studies on open surgery included small cohorts with short follow-ups. Methods: Patients undergoing primary minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for degenerative pathology were retrospectively reviewed and stratified by Short Form (SF-36) Mental Component Summary (MCS): low MCS (<50, n = 436) versus high MCS (≥50, n = 363). PROMs assessed were back pain, leg pain, North American Spine Society Neurogenic Symptoms, Oswestry Disability Index, SF-36 Physical Component Summary, and MCS. Satisfaction, expectation fulfilment, and return to work (RTW) rates also were recorded at 1 month, 3 months, 6 months, and 2 years. Results: Preoperative MCS was 39.4 ± 8.6 and 58.5 ± 5.4 in the low and high MCS groups, respectively ( P < .001). The low MCS group had significantly poorer preoperative PROMs and longer lengths of stay. Despite this, both groups achieved comparable PROMs from 3 months onward. The mean MCS was no longer significantly different by 3 months ( P = .353). The low MCS group had poorer satisfaction ( P = .022) and expectation fulfilment ( P = .020) at final follow-up. RTW rates were initially lower in the low MCS group up to 3 months ( P = .034), but the rates converged from 6 months onward. Conclusions: Despite poorer PROMs preoperatively, patients with poor baseline mental health still achieved comparable results from 3 months up to 2 years after MIS-TLIF. Preoperative optimization of mental health should still be pursued to improve satisfaction and prevent delayed RTW after surgery.
Dentists’ Adoption of Silver Diamine Fluoride among 1- to 5-Year-Old Children in North Carolina
Authors: Meyer B.D. , Kelly E.R. , McDaniel P. 
Published: March 2020

Background: A natural experiment was conducted to observe the adoption of silver diamine fluoride (SDF) by Medicaid-enrolled dentists in North Carolina (NC). The purpose of this study was to describe the sociocontextual and community health characteristics where dentists adopted SDF, determine the association between SDF use and general anesthesia (GA) use, and examine the changes in GA utilization following implementing SDF reimbursement. Methods: NC Medicaid initiated SDF reimbursement in 2016 for children ages 1 to 5 y. This cross-sectional time series study used aggregate NC Medicaid claims, including geographic data, from 2014 to 2018. All dentists who provided GA and/or SDF to children ages 1 to 5 y were included. County health ranking data described social and community health indicators. Descriptive statistics, spatial data techniques, and multivariable methods were used. Results: From 2016 to 2018, the number of dentists using SDF increased from 35 to 258, or 637%, whereas the number of dentists using GA increased from 179 to 211, or 17%. SDF utilization spread outward from areas of good social and health indicators to areas of poorer indicators. SDF utilization increased from 0.35 to 0.65 per 1,000 children, whereas GA utilization decreased from 2.57 to 2.47 per 1,000 children. GA utilization was positively associated with SDF utilization and poorer county health ranking but did not change before and after SDF implementation. Conclusion: Early adopters of SDF in NC practiced in areas with positive social and community health indicators. Over time, SDF was adopted in resource-poor communities. It remains too early to determine the public health impacts of SDF treatment on GA utilization. Knowledge Transfer Statement: Policy makers and clinicians can use the results of this study to develop geographically targeted interventions that could lead to clinically and cost-effective public health programs.
Trial design and pilot phase results of a cluster-randomised intervention trial to improve stroke care after hospital discharge – The structured ambulatory post-stroke care program (SANO)
Authors: Eichner Felizitas A , Schwarzbach Christopher J , Keller Moritz , Haeusler Karl Georg , Hamann Gerhard F , Sander Dirk , Audebert Heinrich J , Gröschel Klaus , Geis Dieter , von Bandemer Stephan , Rücker Viktoria , Schutzmeier Martha , Heuschmann Peter Ulrich , Grau Armin ,   The SANO Study Group
Published: March 2020

Introduction Previous studies showed insufficient control of cardiovascular risk factors (CVRF) and high stroke recurrence rates among ischemic stroke patients in Germany. Currently, no structured secondary prevention program exists in clinical routine. We present the trial design and pilot phase results of a complex intervention to improve stroke care after hospital discharge in Germany. Patients and methods SANO is a cluster-randomized trial with 30 participating regions across Germany aiming to enrol 2,790 patients (drks.de, DRKS00015322). Study intervention combines both structural and patient-centred elements. Study development was based on the Medical Research Council framework for complex interventions. In 15 intervention regions, a cross-sectoral multidisciplinary network is established to enhance CVRF control as well as detection and treatment of post-stroke complications. Recommendations on CVRF are based on high-quality secondary prevention guidelines. Study physicians use motivational interviewing and agree with patients on therapeutic targets. While hospitalised, patients also receive dietary counselling and a health-passport to track their progress. During regular visits, CVRF management and potential complications are monitored. The intervention is compared to 15 regions providing usual care. The primary endpoint is the combination of recurrent stroke, myocardial infarction and death assessed 12 months after enrolment and adjudicated in a blinded manner. Results Eighteen patients were enrolled in a pilot phase that demonstrated feasibility of patient recruitment and study procedures. Conclusion SANO is investigating a program to reduce outcome events after ischemic stroke by implementing a complex intervention. If successful, the program may be implemented in routine care on national level in Germany.
Thermal degradation kinetics of sepiolite
Authors: Sarıkaya Yüksel , Önal Müşerref , Pekdemir Abdullah Devrim 
Published: March 2020

AbstractThe kinetic parameters of the thermal degradation of sepiolite were evaluated with a new method based on thermal analysis data. Thermogravimetric/differential thermal analysis curves were recorded for the natural and preheated sepiolite samples in the temperature range 25–800°C for 4 h. The temperature-dependent height of the exothermic heat flow peak for the thermal decomposition of sepiolite located at ~850°C on the differential thermal analysis curve was taken as a kinetic variable for the thermal degradation. A thermal change coefficient was defined depending on this variable because this coefficient fit to the Arrhenius equation was assumed as a rate constant for the thermal degradation. The Arrhenius plot showed that the degradation occurs in three steps. Two of these are due to stepwise dehydration and the third originated from dehydroxylation of sepiolite. Three activation energies were obtained that increase with the increasing temperature interval of the steps.
Abscisic Acid Negatively Modulates Heat Tolerance in Rolled Leaf Rice by Increasing Leaf Temperature and Regulating Energy Homeostasis
Authors: Li Guangyan , Zhang Caixia , Zhang Guangheng , Fu Weimeng , Feng Baohua , Chen Tingting , Peng Shaobing , Tao Longxing , Fu Guanfu 
Published: March 2020

Abstract
Background
Abscisic acid (ABA) acts as a signaling hormone in plants against abiotic stress, but its function in energy homeostasis under heat stress is unclear.

Results
Two rice genotypes, Nipponbare (wild-type, WT) with flat leaves and its mutant high temperature susceptibility (hts) plant with semi-rolled leaves, were subjected to heat stress. We found significantly higher tissue temperature, respiration rate, and ABA and H2O2 contents in leaves as well as a lower transpiration rate and stomatal conductance in hts than WT plants. Additionally, increased expression of HSP71.1 and HSP24.1 as well as greater increases in carbohydrate content, ATP, NAD (H), and dry matter weight, were detected in WT than hts plants under heat stress. More importantly, exogenous ABA significantly decreased heat tolerance of hts plants, but clearly enhanced heat resistance of WT plants. The increases in carbohydrates, ATP, NAD (H), and heat shock proteins in WT plants were enhanced by ABA under heat stress, whereas these increases were reduced in hts plants.

Conclusion
It was concluded that ABA is a negative regulator of heat tolerance in hts plants with semi-rolled leaves by modulating energy homeostasis.
DePicT Melanoma Deep-CLASS: a deep convolutional neural networks approach to classify skin lesion images
Authors: Nasiri Sara , Helsper Julien , Jung Matthias , Fathi Madjid 
Published: March 2020

AbstractBackgroundMelanoma results in the vast majority of skin cancer deaths during the last decades, even though this disease accounts for only one percent of all skin cancers’ instances. The survival rates of melanoma from early to terminal stages is more than fifty percent. Therefore, having the right information at the right time by early detection with monitoring skin lesions to find potential problems is essential to surviving this type of cancer.ResultsAn approach to classify skin lesions using deep learning for early detection of melanoma in a case-based reasoning (CBR) system is proposed. This approach has been employed for retrieving new input images from the case base of the proposed system DePicT Melanoma Deep-CLASS to support users with more accurate recommendations relevant to their requested problem (e.g., image of affected area). The efficiency of our system has been verified by utilizing the ISIC Archive dataset in analysis of skin lesion classification as a benign and malignant melanoma. The kernel of DePicT Melanoma Deep-CLASS is built upon a convolutional neural network (CNN) composed of sixteen layers (excluding input and ouput layers), which can be recursively trained and learned. Our approach depicts an improved performance and accuracy in testing on the ISIC Archive dataset.ConclusionsOur methodology derived from a deep CNN, generates case representations for our case base to use in the retrieval process. Integration of this approach to DePicT Melanoma CLASS, significantly improving the efficiency of its image classification and the quality of the recommendation part of the system. The proposed method has been tested and validated on 1796 dermoscopy images. Analyzed results indicate that it is efficient on malignancy detection.
GSP4PDB: a web tool to visualize, search and explore protein-ligand structural patterns
Authors: Angles Renzo , Arenas-Salinas Mauricio , García Roberto , Reyes-Suarez Jose Antonio , Pohl Ehmke 
Published: March 2020

Abstract
Background
In the field of protein engineering and biotechnology, the discovery and characterization of structural patterns is highly relevant as these patterns can give fundamental insights into protein-ligand interaction and protein function. This paper presents GSP4PDB, a bioinformatics web tool that enables the user to visualize, search and explore protein-ligand structural patterns within the entire Protein Data Bank.

Results
We introduce the notion of graph-based structural pattern (GSP) as an abstract model for representing protein-ligand interactions. A GSP is a graph where the nodes represent entities of the protein-ligand complex (amino acids and ligands) and the edges represent structural relationships (e.g. distances ligand - amino acid). The novel feature of GSP4PDB is a simple and intuitive graphical interface where the user can “draw” a GSP and execute its search in a relational database containing the structural data of each PDB entry. The results of the search are displayed using the same graph-based representation of the pattern. The user can further explore and analyse the results using a wide range of filters, or download their related information for external post-processing and analysis.

Conclusions
GSP4PDB is a user-friendly and efficient application to search and discover new patterns of protein-ligand interaction.
FLIR vs SEEK thermal cameras in biomedicine: comparative diagnosis through infrared thermography
Authors: Kirimtat Ayca , Krejcar Ondrej , Selamat Ali , Herrera-Viedma Enrique 
Published: March 2020

Abstract
Background
In biomedicine, infrared thermography is the most promising technique among other conventional methods for revealing the differences in skin temperature, resulting from the irregular temperature dispersion, which is the significant signaling of diseases and disorders in human body. Given the process of detecting emitted thermal radiation of human body temperature by infrared imaging, we, in this study, present the current utility of thermal camera models namely FLIR and SEEK in biomedical applications as an extension of our previous article.

Results
The most significant result is the differences between image qualities of the thermograms captured by thermal camera models. In other words, the image quality of the thermal images in FLIR One is higher than SEEK Compact PRO. However, the thermal images of FLIR One are noisier than SEEK Compact PRO since the thermal resolution of FLIR One is 160 × 120 while it is 320 × 240 in SEEK Compact PRO.

Conclusion
Detecting and revealing the inhomogeneous temperature distribution on the injured toe of the subject, we, in this paper, analyzed the imaging results of two different smartphone-based thermal camera models by making comparison among various thermograms. Utilizing the feasibility of the proposed method for faster and comparative diagnosis in biomedical problems is the main contribution of this study.
Comparison of alternative approaches for difference, noninferiority, and equivalence testing of normal percentiles
Authors: Shieh Gwowen 
Published: March 2020

AbstractBackgroundPercentiles are widely used in scientific research for determining the comparative magnitude and reference limit of quantitative measurements. The investigations for point and interval estimation of normal percentiles are well documented in the literature. However, the corresponding statistical tests of hypothesis have received relatively little attention.MethodsTo facilitate data analysis and design planning of percentile study, this paper aims to present hypothesis testing procedures and associated power functions for assessing the difference, noninferiority, and equivalence of normal percentiles.ResultsNumerical illustrations about drug dissolution are provided to demonstrate the usefulness of the suggested exact approaches and the deficiency of approximate methods.ConclusionsThe exact approaches are superior to the approximate methods on the basis of control of Type I errors. Computer algorithms are constructed to implement the recommended test procedures and sample size calculations for percentile analysis.
Toric intraocular lens implantation in cataract patients with corneal opacity
Authors: Ra Ho , Hwang Ho Sik , Kim Hyun Seung , Kim Man Soo , Kim Eun Chul 
Published: March 2020

Abstract
Background
To evaluate the effect of toric intraocular lens implantation in cataract patient with corneal opacity and high astigmatism.

Methods
Thirty-one eyes of 31 patients who underwent cataract surgery with toric intraocular lens implantation were included. All patients had corneal opacity with astigmatism. Preoperative total corneal astigmatism was determined considering posterior astigmatism using a rotating Scheimpflug camera (Pentacam®: Oculus, Wetzlar, Germany). At 2 months after toric intraocular lens implantation, we evaluated residual astigmatism, uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA).

Results
Postoperative UCVA and BCVA (0.30 ± 0.17, 0.22 ± 0.16LogMAR) were statistically improved compared to preoperative UCVA and BCVA (1.2 ± 0.34, 1.1 ± 0.30LogMAR, respectively) (P < 0.01). Postoperative residual refractive astigmatism (1.2 ± 0.35D) was statistically reduced compared to preoperative refractive astigmatism (2.4 ± 0.65D) (P < 0.05). Preoperative and postoperative total corneal astigmatism values were not statistically different. All eyes achieved postoperative visual acuity as good as or better than preoperative one. The size of corneal opacity covering pupil had significant negative correlation with postoperative UCVA and BCVA (logMAR) (R = 0.91 P < 0.05 and R = 0.92 P < 0.05, respectively).

Conclusion
Toric intraocular lens implantation can improve UCVA, BCVA, and refractive astigmatism in cataract patient with corneal opacity. The size of corneal opacity covering pupil is the major prognostic factor for postoperative visual improvement. Therefore, toric intraocular lens implantation should be considered for cataract patients who have corneal opacity with high astigmatism.
Comparison of relationships among French adult siblings with or without schizophrenia using the ASRQ-S: mediating effect on emotional distress
Authors: Plessis Léa , Wilquin Hélène , Pavani Jean-Baptiste , Bouteyre Evelyne 
Published: March 2020

Abstract
Background
Good sibling relationships in adulthood are known to be a protective factor for mental health. The present study examined and compared the relationships of siblings with either a healthy brother or sister or one experiencing schizophrenia.

Methods
In the first phase, we ran a statistical comparison of the two sibling groups on the quality of their sibling relationships (warmth, conflict, and rivalry), emotional distress, and self-esteem. In the second phase, we looked at whether the quality of the sibling relationship modifies the impact of having a brother or sister with schizophrenia on emotional distress and self-esteem.

Results
Results showed that sibling relationships in schizophrenia are less warm and are characterized by heightened rivalry and conflict. In addition, analysis revealed a mediating effect of sibling relationship on the emotional distress of siblings with a brother/sister diagnosed with schizophrenia.

Conclusion
More needs to be done to enhance the mental health of adults who have a brother or sister with schizophrenia, notably via their sibling relationships.
Finite element analysis of archwire parameters and activation forces on the M/F ratio of vertical, L- and T-loops
Authors: Cai Yongqing 
Published: March 2020

AbstractBackgroundThe ability of a loop to generate a certain moment/force ratio (M/F ratio) can achieve the desired tooth movement in orthodontics. The present study aimed to investigate the effects of elastic modulus, cross-sectional dimensions, loop configuration geometry dimensions, and activation force on the generated M/F ratio of vertical, L- and T-loops.MethodsA total of 120 three-dimensional loop models were constructed with the Solidworks 2017 software and used for simulating loop activation with the Abaqus 6.14 software. Six vertical loop variations, 9 L-loop variations, and 9 T-loop variations were evaluated. In each group, only one parameter was variable [loop height, ring radius, leg length, leg step distance, legs distance, upper length, different archwire materials (elastic modulus), cross-sectional dimension, and activation force].ResultsThe simulation results of the displacement and von Mises stress of each loop were investigated. The maximum displacement in the height direction was recorded to calculate the M/F ratio. The quantitative change trends in the generated M/F ratio of the loops with respect to various variables were established.ConclusionsIncreasing the loop height can increase the M/F ratio of the loop. This increasing trend is, especially, much more significant in T-loops compared with vertical loops and L-loops. In vertical loops, increasing the ring radius is much more effective than increasing the loop height to increase the M/F ratio of the loop. Compared with SS, TMA archwire loops can generate a higher M/F ratio due to its lower elastic modulus. Loops with a small cross-sectional area and high activation force can generate a high M/F ratio. The introduction of a leg step to loops does not increase the M/F ratio of loops.