bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry's Voluntary Program: Community Awareness and Emergency Response Program and the Emergency Planning and Community Right-to-Know Act
Authors: Cooper Josephine S. 
Published: March 2020

This paper describes the chemical industry's Community Awareness and Emergency Response (CAER) Program, and voluntary and mandatory actions by the chemical industry to comply with the major environmental legislation. The chemical industry started the voluntary CAER Program soon after the Bhopal Disaster in 1984; it is coordinated through the Chemical Manufacturer's Association. This program, which began in March 1985, is a long-term industry commitment to develop a community outreach program and to improve local emergency response planning. The Congress of the United States began, in 1985, to consider proposals for mandatory programs. This led to enactment of the Superfund Amendments and Reauthorization Act of 1986, known as SARA. A portion of this Act, entitled Title III is also known as the Emergency Planning and Community Right-to-Know Act. Although this legislation has many mandatory requirements, it should be emphasized that a significant degree of voluntary industrial participation is needed if the purposes of the statute are to be achieved. Title III has created an intricate and still evolving system that ties together the EPA, industrial plant managers, state emergency response commissions, local emergency planning committees and fire departments with jurisdiction over the facility. Each of these groups has a different role and responsibilities but must work cooperatively with other participants. Because of the intricate network of participants, the magnitude of the information flow, and the continuing evolution of the system, unique public relations problems exist in order to comply with Title III. While understanding demands that we know the nature of the statutory system and how to deal with the basics of the system, in the last analysis the measure of that understanding is to be found in the realities of the daily operations of the plant and the on-going life of the community in which it is embedded. Actions that are responsible, unfamiliar and even costly are needed. In some ways, the response to this legislation can be viewed as a test of whether the nation can find a way to assert collegiality through joint and voluntary efforts rather than becoming adversaries in courts or legislatures.
Effects of Burnrate, Wood Species, Altitude, and Stove Type on Woodstove Emissions
Authors: McCrillis Robert C. , Burnet Paul G. 
Published: March 2020

During the winter of 1986—87, the U.S. Environmental Protection Agency (EPA) conducted an emission measurement program in Boise, ID, as part of the Integrated Air Cancer Project (IACP). This program was designed to identify the potential mutagenic impact of residential wood burning on ambient and indoor air. One facet of this field sampling effort involved obtaining emission samples from chimneys serving wood burning appliances in Boise. As a companion to the field source sampling, a parallel project was undertaken in an instrumented woodstove test laboratory to quantify woodstove emissions during operations typical of Boise usage. Two woodstoves were operated in a test laboratory over a range of burnrates, burning either eastern oak or white pine from the Boise, ID, area. A conventional stove, manufactured in the Boise area, was tested at altitudes of 90 and 825 m. A catalytic stove was tested only at the high altitude facility. All emission tests were started with kindling a fire in a cold stove using black and white newsprint. Emissions were collected using the wood stove dilution sampling system (WSDSS) for a continuous period of about 8 hours, encompassing start-up and several wood additions. The results showed wide variability probably due primarily to the difficulty in duplicating conditions during start-up. Total WSDSS emissions showed the expected inverse correlations with burnrate for the conventional stove and nearly flat for the catalytic stove. While there appeared to be little or no correlation of total WSDSS emissions with altitude, the sum of the 16 poly-nuclear aromatic hydrocarbons (PAHs) quantified showed an inverse correlation with altitude: higher PAH emissions at the lower altitude.
The U.S. Environmental Protection Agency's Risk Assessment Guidelines
Authors: Jarabek Annie M. , Farland William H. 
Published: March 2020

This paper has been reviewed by the Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. In 1983, the U.S. National Academy of Sciences (U.S. NAS) proposed a framework for the processes of risk assessment and risk management in government agencies (U.S. NAS, 1983). Using the U.S. NAS scheme as an organizing principle, the U.S. Environmental Protection Agency (U.S. EPA) published guidelines pertaining to risk assessment in five areas: estimating exposures, chemical mixtures, mutagenicity, suspect developmental toxicity and carcinogenicity. These guidelines were developed to promote high technical quality and consistent practice of risk assessment Agencywide. This paper will discuss the historical development of the guidelines and their role in the work performed by the Agency. Each of the five (5) guidelines is outlined and anticipated revisions discussed. Related assessment activities and new subject areas are also presented.
Epa's Control Technology Approach to Assisting States and Regions with Air Toxics Problems: Five Case Studies
Authors: Nolen Sharon L. , Dimmick W. Fred 
Published: March 2020

The Environmental Protection Agency (EPA) announced in June 1985 a new strategy to reduce public exposure to toxic air pollutants in the ambient air. Over the next 5–8 years, the strategy called for State and Local authorities to take on more of the lead regulatory role, with the Agency providing technical and financial assistance to their efforts. The shift in emphasis and responsibility from the Federal level to State and Local air toxics programs and the need to transfer expertise from the Federal level to the appropriate State or Local level prompted EPA's Office of Research and Development (ORD) and EPA's Office of Air Quality Planning and Standards (OAQPS) to develop and implement an innovative technical assistance program. This program is called the Control Technology Center (CTC). It has since been expanded to include technical assistance in the area of control of air toxics, particulate matter, and volatile organic compounds (VOCs); emission measurements; and other areas where expertise is available to ORD and OAQPS. During the CTC's first year of operation, operating guidelines were developed and three categories of technical assistance were established. These categories are telephone HOTLINE calls, direct engineering assistance, and technical guidance projects. The CTC HOTLINE is a special telephone number which State and Local Agencies can call for easy access to EPA personnel who can provide prompt assistance in a variety of ways including discussions, references to pertinent literature, and referrals to other EPA personnel. In some cases, a HOTLINE call will require more in-depth engineering analysis indicating a need for direct engineering assistance. These projects tend to be short-term (2 to 3 months) and specific in nature. In some cases, several agencies may indicate a need for information on the same source, or a group of Agencies may make a joint request. In these cases, the CTC Steering Committee, a group who advises the CTC managers, may decide that a technical guidance project is indicated. Technical guidance projects are longer-term and are intended to be of broad interest, useful to many agencies. This paper discusses the development of the CTC, experience to date with its operation, and future plans. In addition, five CTC projects are discussed to illustrate the assistance provided.
Risk Analysis in Renewable Energy System (RES) Investment for a Developing Country: A Case Study in Pakistan
Authors: Gul Izzet Alp , Kayakutlu Gülgün , Kayalica M. Özgür 
Published: March 2020

Technological improvements allow changing a significant part of the electricity generation investments to renewable energies. Especially in emerging markets and energy import-dependent countries, shift to renewable energy generation became more important to break the links of dependency. Pakistan relies on imported fossil fuels; however, the country’s experience and ambition about the renewable energy transition gain prominence in recent years. Considering the long-term life cycle of energy infrastructure investments, possible risk factors and their dynamic nature must be analysed before the financial decisions are taken. This article aims to propose a system dynamics model for the risk analysis of investment life cycle. In this study, possible risk factors are detected and discussed in different categories. The casual loop diagram of possible risk factors and risk assessment model are designed, and the impacts are analysed. Case study of the proposed model in Pakistan highlighted the importance of commercial risks. The results achieved through this study will guide investors, sector participants and policymakers to develop stable strategies for promoting renewable energy in the country. JEL: Q42, P48, O13
Conversion of diffusely abnormal white matter to focal lesions is linked to progression in secondary progressive multiple sclerosis
Authors: Dadar Mahsa , Narayanan Sridar , Arnold Douglas L , Collins D Louis , Maranzano Josefina 
Published: March 2020

Background: Diffusely abnormal white matter (DAWM) regions are observed in magnetic resonance images of secondary progressive multiple sclerosis (SPMS) patients. However, their role in clinical progression is still not established. Objectives: To characterize the longitudinal volumetric and intensity evolution of DAWM and focal white matter lesions (FWML) and assess their associations with clinical outcomes and progression in SPMS. Methods: Data include 589 SPMS participants followed up for 3 years (3951 time points). FWML and DAWM were automatically segmented. Screening DAWM volumes that transformed into FWML at the last visit (DAWM-to-FWML) and normalized T1-weighted intensities (indicating severity of damage) in those voxels were calculated. Results: FWML volume increased and DAWM volume decreased with an increase in disease duration ( p < 0.001). The Expanded Disability Status Scale (EDSS) was positively associated with FWML volumes ( p = 0.002), but not with DAWM. DAWM-to-FWML volume was higher in patients who progressed (2.75 cm3 vs. 1.70 cm3; p < 0.0001). Normalized T1-weighted intensity of DAWM-to-FWML was negatively associated with progression ( p < 0.00001). Conclusion: DAWM transformed into FWML over time, and this transformation was associated with clinical progression. DAWM-to-FWML voxels had greater normalized T1-weighted intensity decrease over time, in keeping with relatively greater tissue damage. Evaluation of DAWM in progressive multiple sclerosis provides a useful measure for therapies aiming to protect this at-risk tissue with the potential to slow progression.
Exposure to passive smoking during adolescence is associated with an increased risk of developing multiple sclerosis
Authors: Oturai Ditte Bang , Bach Søndergaard Helle , Koch-Henriksen Nils , Andersen Christina , Laursen Julie Hejgaard , Gustavsen Stefan , Kristensen Joachim Tilsted , Magyari Melinda , Sørensen Per Soelberg , Sellebjerg Finn , Thørner Lise Wegner , Ullum Henrik , Oturai Annette Bang 
Published: March 2020

Background: Environmental factors are associated with acquiring multiple sclerosis (MS) particularly in adolescence. Objective: To test for association between MS and exposure to passive smoking at the age of 10–19. Methods: A total of 919 patients from the Danish MS Registry and Biobank and 3419 healthy blood donors who had not smoked before the age of 19 were targeted. We analyzed separately for each sex and for those never-smokers (cohort 1) and active smokers above the age of 19 (cohort 2). All participants completed standardized questionnaires about smoking and lifestyle. We matched cases and controls in the ratio of 1:2 by propensity scores discarding unmatchable individuals and used logistic regression adjusted for all covariates and interactions. Results: After matching, we included 110/213 male cases/controls and 232/377 female case/controls in cohort 1. In cohort 2, the numbers were 160/320 and 417/760, respectively. Among women in cohort 1, the odds ratio (OR) for MS by passive smoking at the age of 10–19 was 1.432 ( p = 0.037) but in men it was 1.232 ( p = 0.39). Among men in cohort 2, OR was 1.593 ( p = 0.022) but among women it was only 1.102 ( p = 0.44). Conclusion: Among never smokers, female MS cases were more often than female controls reported with passive smoking between the age of 10 and 19, and among smokers above the age of 19, male MS patients were more often than male controls reported with passive smoking.
Grammatical gender-marking ability of multilingual children in French immersion
Authors: Krenca Klaudia , Hipfner-Boucher Kathleen , Chen Xi 
Published: March 2020

Aims and objectives/purpose/research questions: We explored the advantage of bilingualism and the effect of linguistic proximity on the acquisition of determiner-noun agreement, an aspect of inflectional morphology, in a French immersion setting. To our knowledge, third language acquisition literature has yet to provide evidence of a bilingual advantage in learning a particular feature of morphology in an additional language among young children. Design/methodology/approach: We compared accuracy in determiner-noun agreement on a narrative task in three groups of grade 1 and 2 students ( n = 15 in each group): a group of third language French learners whose first language marked gender, a group of third language French learners whose first language did not mark gender, and a group of English learners learning French as a second language. Data and analysis: If the determiner and the noun agreed in gender, gender on the determiner was considered correct. A repeated measures factorial ANCOVA was carried out to compare the performance among the three language groups on the proportion of correctly marked masculine and feminine nouns. Findings/conclusions: All of the children achieved high levels of accuracy on masculine nouns with no difference among the three language groups on the proportion of correctly marked masculine nouns. There was a significant difference in the proportion of correctly marked feminine nouns in favour of the group whose first language marks gender compared to the other two groups. Originality: The current study supports transfer in the domain of morphology among primary-school-aged children (who are first language speakers of diverse minority languages) in the early stages of third-language French acquisition. Significance/implications: This finding provides preliminary evidence of a bilingual advantage in the domain of morphology among young, emergent trilinguals whose first language and third language share gender marking as a linguistic feature, supporting the linguistic proximity model.
Vicarious Learning From Innovative Women Entrepreneurs in Thailand
Authors: Sritanyarat Dawisa , Sakdiyakorn Malinvisa 
Published: March 2020

The Problem The number of Thai women entrepreneurs has increased to nearly half of all Thai entrepreneurs over the past years with 80% of them reported to have entered into opportunity-driven entrepreneurship. This growing social phenomenon, however, remains underexplored by limited numbers of academic studies on Thai women entrepreneurship. Extending the understanding of opportunity-driven women entrepreneurs in the changing Thai context is therefore significant for developing national human resources. The Solution This study highlights the opportunity-driven category of women entrepreneurs defined by Cromie and Hayes as Innovators. Taking the phenomenological approach as a research method, in-depth interviews from 13 innovative women business owners in Thailand were analyzed to understand their motivations, challenges, and success factors, as well as the contemporary worldview of the Thai culture and values concerning gender roles and social norms. The Stakeholders National policymakers, educators, human resource development professionals, and parents can craft policies and practices that align with key learnings from the lived experiences of women entrepreneurs. Aspiring women entrepreneurs can also vicariously learn from the study participants who serve as role models.
Animating Management: Nonlinear Simulation and Management Theory at Pixar
Authors: Gowanlock Jordan 
Published: March 2020

Existing scholarship finds that early industrialized animation studios sought to emphasize the unpredictable liveliness of creativity at their studios, while also demonstrating their ability to control and manage production through industrial management techniques that promoted regulation and efficiency. This article examines how this dynamic between unpredictability and control has been negotiated by digital animation studios since the early 1980s, with a focus on the way Pixar Animation Studios represents its management theory through popular books, business journal articles, DVD extras, and behind-the-scenes promotional material.This article highlights how computational principles for creating and managing unpredictability via nonlinear simulation inform Pixar’s promoted management theory. The principles of simulated unpredictability ground many of Pixar’s key technological advances, especially for animating fluids and materials (water, smoke, fur, and cloth), but they also ground concepts within the field of management science such as industrial dynamics and organizational resilience. This epistemic frame leads Pixar to represent creativity as the unpredictable product of carefully controlled conditions and parameters and this collapse of technology, animation, and management helps to sculpt Pixar’s own corporate image as both an animation studio and technology company. The research in this article offers contributions to the study of both post-Fordism in animation industries and algorithmic control.
How I treat CMV reactivation after allogeneic hematopoietic stem cell transplantation
Authors: Einsele Hermann , Ljungman Per , Boeckh Michael 
Published: March 2020

Abstract
Cytomegalovirus (CMV) reactivation remains one of the most common and life-threatening infectious complications following allogeneic hematopoietic stem cell transplantation, despite novel diagnostic technologies, several novel prophylactic agents, and further improvements in preemptive therapy and treatment of established CMV disease. Treatment decisions for CMV reactivation are becoming increasingly difficult and must take into account whether the patient has received antiviral prophylaxis, the patient’s individual risk profile for CMV disease, CMV-specific T-cell reconstitution, CMV viral load, and the potential drug resistance detected at the time of initiation of antiviral therapy. Thus, we increasingly use personalized treatment strategies for the recipient of an allograft with CMV reactivation based on prior use of anti-CMV prophylaxis, viral load, the assessment of CMV-specific T-cell immunity, and the molecular assessment of resistance to antiviral drugs.
How I treat steroid-refractory acute graft-versus-host disease
Authors: Martin Paul J. 
Published: March 2020

Abstract
Steroid-resistant or steroid-refractory acute graft-versus-host disease (SR-aGVHD) poses one of the most vexing challenges faced by providers who care for patients after allogeneic hematopoietic cell transplantation. For the past 4 decades, research in the field has been driven by the premise that persistent graft-versus-host disease (GVHD) results from inadequate immunosuppression. Accordingly, most efforts to solve this problem have relied on retrospective or prospective studies testing agents that have direct or indirect immunosuppressive effects. Retrospective studies far outnumber prospective studies, and no controlled prospective trial has shown superior results for any agent over others. Truth be told, I do not know how to treat SR-aGVHD. Preclinical work during the past decade has provided fresh insights into the pathogenesis of acute GVHD, and translation of these insights toward development of more effective treatments for patients with SR-aGVHD has at last begun. Given the limited state of current knowledge, this “How I Treat” review highlights the overriding imperative to avoid harm in caring for patients with SR-aGVHD. Prospective trials that are widely available are urgently needed to advance the field.
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS
Authors: Chen Bing-Yi , Song Junhong , Hu Cheng-Long , Chen Shu-Bei , Zhang Qunling , Xu Chun-Hui , Wu Ji-Chuan , Hou Dan , Sun Ming , Zhang Yuan-Liang , Liu Na , Yu Peng-Cheng , Liu Ping , Zong Li-Juan , Zhang Jia-Ying , Dai Ruo-Fei , Lan Fei , Huang Qiu-Hua , Zhang Su-Jiang , Nimer Stephen D. , Chen Zhu , Chen Sai-Juan , Sun Xiao-Jian , Wang Lan 
Published: March 2020

Abstract
SETD2, the histone H3 lysine 36 methyltransferase, previously identified by us, plays an important role in the pathogenesis of hematologic malignancies, but its role in myelodysplastic syndromes (MDSs) has been unclear. In this study, low expression of SETD2 correlated with shortened survival in patients with MDS, and the SETD2 levels in CD34+ bone marrow cells of those patients were increased by decitabine. We knocked out Setd2 in NUP98-HOXD13 (NHD13) transgenic mice, which phenocopies human MDS, and found that loss of Setd2 accelerated the transformation of MDS into acute myeloid leukemia (AML). Loss of Setd2 enhanced the ability of NHD13+ hematopoietic stem and progenitor cells (HSPCs) to self-renew, with increased symmetric self-renewal division and decreased differentiation and cell death. The growth of MDS-associated leukemia cells was inhibited though increasing the H3K36me3 level by using epigenetic modifying drugs. Furthermore, Setd2 deficiency upregulated hematopoietic stem cell signaling and downregulated myeloid differentiation pathways in the NHD13+ HSPCs. Our RNA-seq and chromatin immunoprecipitation–seq analysis indicated that S100a9, the S100 calcium-binding protein, is a target gene of Setd2 and that the addition of recombinant S100a9 weakens the effect of Setd2 deficiency in the NHD13+ HSPCs. In contrast, downregulation of S100a9 leads to decreases of its downstream targets, including Ikba and Jnk, which influence the self-renewal and differentiation of HSPCs. Therefore, our results demonstrated that SETD2 deficiency predicts poor prognosis in MDS and promotes the transformation of MDS into AML, which provides a potential therapeutic target for MDS-associated acute leukemia.