bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of a Preoperative Systemic Immune-inflammation Index as a Predictor of Postoperative Survival Outcomes in Gastric Cancer
Authors: Inoue Hiroyuki , Kosuga Toshiyuki , Kubota Takeshi , Konishi Hirotaka , Shiozaki Atsushi , Okamoto Kazuma , Fujiwara Hitoshi , Otsuji Eigo 
Published: October 2020

Abstract
Background Since inflammation and the immune system contribute to the development and progression of malignancies, parameters that reflect a host’s immune-inflammatory status may be useful prognostic indicators of gastric cancer (GC). The present study examined the clinical significance of a preoperative systemic immune-inﬂammation index (SII) for predicting postoperative survival outcomes in GC.Methods A total of 447 patients who underwent curative gastrectomy for GC were included in the present study. SII was calculated as platelet count × neutrophil count/lymphocyte count. The prognostic impact of preoperative SII was examined using univariate and multivariate analyses.Results Preoperative SII ranged between 105 and 4455 (median 474), and the optimal cut-off value for predicting overall survival (OS) was 395 based on a receiver operating characteristic curve. The 5-year OS rate of the SII≥395 group was 80.0%, which was significantly worse than that (92.7%) of the SII<395 group (p<0.001). The multivariate analysis identified SII≥395 (Hazard ratio [HR] 3.016; 95% confidence interval [CI] 1.593-6.262; p<0.001), carcinoembryonic antigen≥5.0 (HR 2.224, 95% CI 1.128-4.100), pT4 (HR 4.554, 95% CI 2.525-8.234), and pN+ (HR 3.621, 95% CI 1.916-7.074) as independent predictors of worse OS. Peritoneal recurrence was more frequent in the high SII group than in the low SII group (p=0.028).Conclusion Preoperative SII may be a useful predictor of postoperative survival outcomes in GC. The meticulous surveillance of GC relapse, particularly peritoneal dissemination, is necessary for patients with SII≥395 even after curative gastrectomy.
Oxymatrine Improves the Integrity of the Blood-brain Barrier After Cerebral Ischemia-reperfusion Injury Through the Caveolin-1/MMP-9 Signaling Pathway
Authors: Yu Jiaoyan , Lu Qingqing , Li Xi , Zhao Mei , Sun Ting , Hu Na , Jiang Wei , Zhang Ruitao , Yang Peng , yang qi 
Published: October 2020

Abstract
Ischemic stroke (IS) is a major neurological disease worldwide and is associated with extremely high morbidity and mortality. Oxymatrine (OMT) has neuroprotective properties and protects against IS. However, whether its protective effect involves the blood-brain barrier (BBB) integrity is unknown. In this study, we used in vivo and in vitro models of IS to evaluate the protective effect of OMT and its mechanism with regard to the BBB. Our results showed that OMT significantly improved the neurological function and brain state and reduced BBB permeability in a mouse model of cerebral ischemia-reperfusion. Additionally, OMT improved the tight junction of bEend.3 cells under oxygen-glucose deprivation. Moreover, intracranial lentivirus injection-induced Cav-1 knockdown reduced the neuroprotective effects of OMT. Our results indicated that OMT could improve cI/R injury-induced damage to the BBB, and its effects may be related to the regulation of the Cav-1/MMP-9 signaling pathway. This suggests that OMT may offer effective protection against BBB injury after cI/R.
THE USE OF THE METHODS OF EXTRACORPORAL HEMOCORRECTION IN COMPLEX TREATMENT OF MALIGNANT TUMORS AND REHABILITATION OF CANCER PATIENT
Authors: Gilmutdinova I. R. , Eremin P. S. , Fesyun A. D. , Butenko A. V. 
Published: October 2020

The purpose of the study was to analyze literature data on the use of extracorporal hemocorrection as a pathogenetically significant component of rehabilitation for cancer patients.Material and Methods. Literature search was carried out using keywords: rehabilitation of cancer patients, plasmapheresis, extracorporeal hemocorrection, hemodialysis. Out of 250 selected articles, 42 were used to write a review.Results. Methods of extracorporeal hemocorrection are successfully used in the treatment of a wide range of diseases; therefore, the feasibility of applying these methods for rehabilitation of cancer patients is being studied. The review presents literature data on the feasibility of using the methods of extracorporal hemocorrection methods to compensate for the pathophysiological processes related to cancer development.Conclusion. The analysis shows that a positive experience of using the methods of extracorporal hemocorrection for rehabilitation of cancer patients has been gained. However, no clear criteria for the application of these methods and for the assessment of their effectiveness have been developed.
ARTERIAL RESECTION IN PANCREATIC CANCER SURGERY: A SINGLE-CENTER EXPERIENC
Authors: Сhichevatov D. A. , Kalentev V. V. , Glukhov A. E. 
Published: October 2020

Pancreaticoduodenal resection (PDR) with vascular reconstruction is performed in approximately 20 % of pancreatic cancer patients. The superior mesenteric vein resection and reconstruction has become a standard routine surgery, whereas arterial resection during pancreatic surgery is still an issue of controversial debate.The purpose of the study was to evaluate short-and long-term outcomes of PDR with reconstruction of various arteries.Material and Methods. Outcomes of 89 PDRs and pancreaticoduodenectomies performed in patients with stage II–IV periampullary carcinoma were assessed. The average age of the patients was 63.1 ± 8.2. There were 18 (20.2 %) PDRs with vascular reconstruction, of them 7 (7.8 %) were arterial resections.Results. In patients who underwent artery resection (n=7), complications were observed in 5 (71.4 %) cases. Out of 71 patients who underwent PDR without arterial and/or venous resection, 29 (40.8 %) had complications (p=0.229). The postoperative mortality rates were 1 (14.3 %) and 3 (4.2 %), respectively (p=0.319). The median disease-free survival was 5.0 months (95 % CI 2.4–7.6 months) in the arterial resection group and 12.3 months (95 % CI 9.2–15.4 months) in the standard surgery group (log-rank test, p=0,011). The median overall survival was 8.0 months (95 % CI 3.7–12.3 months) in the in the arterial resection group and 21.8 months (95 % CI 15.9–27.7 months) in the standard surgery group (log-rank test, p=0.011).Conclusion. The disease-free and overall survival rates were significantly worse in the arterial resection group than in the standard surgery group. This is most likely due to a small sample of patients. Further studies are needed to analyze the immediate and long-term treatment outcomes of PDR with arterial resection for pancreatic cancer.
Analysis of Heat Demand and Thermal Comfort in Naturally Ventilated Single-Family Houses of Various Constructions
Authors: FERDYN-GRYGIEREK Joanna , GRYGIEREK Krzysztof , GUMIŃSKA Anna , BARAN Łukasz , BARWA Magdalena , CZERW Kamila , GOWIK Paulina , MAKSELAN Klaudia , POTYKA Klaudia , PSIKUTA Agnes 
Published: October 2020

Abstract
The aim of the paper was a comparative analysis of energy demand for heating and human thermal comfort of a model single-family house with natural ventilation in various construction technologies (wood and brick), located in the Polish temperate climate. The frequency, as well as, the window opening area in the building have been optimized taking into account two objective functions: heating demand and number of thermal discomfort hours. The analyses were based on thermal simulations using the EnergyPlus program on the nine-zone model of the selected house. Each building construction case was calculated for two variants of external partitions insulation. The thermal model, separately for each zone, contained hourly internal heat gain schedules. All simulations were carried out with a 15-minute step for the full calendar year. Analyzes have shown that the heating demand for a building made in wooden technology is higher than a building in brick technology. The wooden building has a greater number of thermal discomfort hours. Increasing the insulation properties of the house increases the number of hours of discomfort.
Efficient solar heterogeneous photocatalytic degradation of metronidazole using heterojunction semiconductors hybrid nanocomposite, layered double hydroxides
Authors: Aoudjit Farid , Touahra Fouzia , Aoudjit Lamine , Cherifi Ouiza , Halliche Djamilla 
Published: October 2020

AbstractThis study focuses on the synthesis of various nanocomposites with heterojunction structures, MgAl-LDH (LDH = layered double hydroxides) hybrid with semiconductor such as MoO3 and CuO. These solids were synthesized by co-precipitation method at constant pH and have been characterized extensively using atomic absorption spectroscopy (AAS), X-ray diffraction (XRD), Fourier transform infrared (FTIR) and transmission electron microscopy-energy dispersive X-ray (TEM-EDX) methods. The catalytic activity of nanocomposites was tested in the photocatalytic degradation under solar irradiation of emerging pollutants as the pharmaceutical metronidazole (MNZ). The experimental parameters, including initial MNZ concentration, the nature of oxide incorporate in the photocatalyst, catalyst loading were explored. All the synthesized samples showed high photocatalytic performances; the highest photocatalysis efficiency was achieved with the photocatalyst dose 1.5 g/L and initial MNZ concentration of 10 mg/L at neutral pH. The photocatalytic experimental results were fitted very well to the Langmuir-Hinshelwood model. From the obtained results the calcined LDH/semiconductors could be efficient for the photocatalytic process under solar irradiation of pharmaceuticals and may contribute in environmental remediation.
Unprecedented Role of the N73-F124 Pair in the Staphylococcus equorum MnSOD Activity
Authors: Retnoningrum Debbie S. , Yoshida Hiromi , Razani Muthia D. , Meidianto Vincencius F. , Hartanto Andrian , Artarini Anita , Ismaya Wangsa T. 
Published: October 2020

Background::
Bacterial manganese superoxide dismutase (MnSOD) occurs as a dimer,
which is responsible for its activity and stability. Therefore, increasing the dimeric strength would increase
the stability of the enzyme while maintaining its activity.

Objective::
An N73F substitution was introduced to strengthen interactions between the monomers at
the dimer interface. This substitution would introduce a π-stacking interaction between F73 of one
monomer to F124 from the other monomers.

Methods:
Site-directed mutagenesis was carried out to substitute N73 with phenylalanine. The activity
of the mutant was qualitative- and quantitatively checked while the stability was evaluated with a fluorescence-
based thermal-shift assay. Finally, the structure of the mutant was elucidated by means of Xray
crystallography.

Results::
The N73F mutant activity was only ~40% of the wild type. The N73F mutant showed one TM
at 60+1°C while the wild type has two (at 52-55°C and 63-67°C). The crystal structure of the mutant
showed the interactions between F73 from one monomer to F124 from the other monomer. The N73F
structure presents an enigma because of no change in the enzyme structure including the active site.
Furthermore, N73 and F124 position and interaction are conserved in human MnSOD but with a different
location in the amino acid sequence. N73 has a role in the enzyme activity, likely related to its interaction
with F124, which resides in the active site region but has not been considered to participate in
the reaction.

Conclusion::
The N73F substitution has revealed the unprecedented role of the N73-F124 pair in the
enzyme activity.
Enhanced Oral Absorption of All-trans Retinoic Acid upon Encapsulation in Solid Lipid Nanoparticles
Authors: Kumar Manoj , Sharma Garima , Singla Dinesh , Singh Sukhjeet , Kakkar Vandita , Gulati Jaspreet S. , Kaur Indu P. 
Published: October 2020

Background::
All-trans retinoic acid (ATRA) is widely employed in the treatment of
various proliferative and inflammatory diseases. However, its therapeutic efficacy is imperiled
due to its poor solubility and stability. Latter was surmounted by its incorporation into a solid
matrix of lipidic nanoparticles (SLNs).

Methods::
ATRA loaded SLNs (ATRA-SLNs) were prepared using a novel microemulsification
technique (USPTO 9907758) and an optimal composition and were characterized in terms of
morphology, differential scanning calorimetry (DSC), and powder X-ray diffraction studies
(PXRD). In vitro release, oral plasma pharmacokinetics (in rats) and stability studies were also
done.

Results::
Rod-shaped ATRA-SLNs could successfully incorporate 3.7 mg/mL of ATRA, increasing
its solubility (from 4.7 μg/mL) by 787 times, having an average particle size of
131.30 ± 5.0 nm and polydispersibility of 0.283. PXRD, DSC, and FTIR studies confirmed the
formation of SLNs. Assay/total drug content and entrapment efficiency of ATRA-SLNs was
92.50 ± 2.10% and 84.60 ± 3.20% (n=6), respectively, which was maintained even on storage
for one year under refrigerated conditions as an aqueous dispersion. In vitro release in 0.01 M
phosphate buffer (pH 7.4) with 3% tween 80 was extended 12 times from 2h for free ATRA to
24 h for ATRA-SLNs depicting Korsmeyer Peppas release. Oral administration in rats showed
35.03 times enhanced bioavailability for ATRA-SLNs.

Conclusion::
Present work reports preparation and evaluation of bioenhanced ATRA-SLNs containing
a high concentration of ATRA (>15 times than that reported by others). Latter is attributed
to the novel preparation process and intelligent selection of components.

Lay Summary:
All-trans retinoic acid (ATRA) shows an array of pharmacological activities
but its efficacy is limited due to poor solubility, stability and side effects. In present study its
solubility and efficacy is improved by 787 and 35.5 times, respectively upon incorporation into
solid lipid nanoparticles (ATRA-SLNs). Latter extended its release by 12 times and provided
stability for at least a year under refrigeration. A controlled and sustained release will reduce
dose related side effects. ATRA-SLNs reported presently can thus be used in treatment
/prophylaxis of disorders like cancers, tuberculosis, age related macular degeneration and acne
and as an immune-booster.
The effectiveness of family welfare movement program in slums
Authors: Kuswardinah Asih 
Published: October 2020

This ex-post-facto research aims to: ¹⁾ describe the implementation of Family Welfare Movement Program (PKK) in slums, as well as responses to the assessment of PKK members regarding the effectiveness of 10 PKK programs implementation; ²⁾ identify skills PKK members are interested in as additional capital to improve income. The research took location at Deliksari Village, a new developing area in Semarang. The total respondents are 58 people determined by purposive sampling. The data collection tool is questions with multiple answers corroborated by the results of in-depth interviews with management, some members and field observations. The study found: ¹⁾ the achievement of program implementation percentage included: ͣ⁾ the average achievement of workgroup I is 16.58 in high category; ᵇ⁾ the average achievement of workgroup II is 15.03 in medium category; ᶜ⁾ the average achievement of workgroup III is 22.12 in medium category, ᵈ⁾ the average achievement of workgroup IV is 29.96 in medium category; ᵉ⁾ the average achievement of workgroup I to IV is 84.48 in medium category; ²⁾ the highest percentage is from residents choosing “baking cookies” skill (63.79 percent). The research conclusion stipulates: ¹⁾ the members routine implementing programs of each workgroup should be routinely monitored by the management of relevant workgroups, then the management strives for facilities and infrastructure for cake making activities; ²⁾ the management encourages members to develop "communication" intensely to implement messages; ³⁾ PKK chairman periodically, formally and informally, motivates the workroup leaders to focus on monitoring and reminding members to implement program messages.
EFEK MODERASI RELIGIUSITAS INTRINSIK, GENDER DAN USIA PADA PENGARUH LOVE OF MONEY TERHADAP TAX EVASION
Authors: Silmi Silmi , Tanno Aries , Firdaus Firdaus 
Published: October 2020

<em>This study aims to examine the effect moderation of intrinsic religiosity, gender and age on influence love of money to tax evasion. Source data of this study is the primary data from online questionnaire shared in electronic by google form. The sample of this study is taxpayers of individual non employee that do business and freelance that registered at the Tax Service Office (TSO) Pratama Bukittinggi city as much as 85 respondents. Data analysis techniques using SEM model with Warp Partial Least Square (PLS) computer program version 6.0. The result of this study show that</em> <em>love of money had a positive effect on the tax evasion. Besides that, </em><em>intrinsic religiosity variable as moderation variable weaken the influence love of money to tax evasion, while the gender and age variable strengthen the influence love of money to tax evasion. Moderation of male gender is bigger than moderation of female gender in moderate the influence love of money to tax evasion and moderation of young age is bigger than moderation of old age in moderate the influence love of money to tax evasion.</em>
Analytical calculation of deformations of a truss for a long span covering
Authors: Kirsanov Mikhail N. 
Published: October 2020

Introduction. The method of induction based on the number of panels is employed to derive formulas designated for deflection of a square in plan hinged rod structure, which has supports on its sides and which consists of individual pyramidal rod elements. The truss is statically determinable and symmetrical. Some features of the solution are identified on the curves constructed according to derived formulas.
Materials and methods. The analysis of forces arising in the rods of the covering is performed symbolically using the method of joint isolation and operators of the Maple symbolic math engine. The deflection in the centre of the covering is found by the Maxwell–Mohr’s formula. The rigidity of truss rods is assumed to be the same. The analysis of a sequence of analytical calculations of trusses, having different numbers of panels, is employed to identify coefficients, designated for deflection and reaction at the supports, in the final design formula. The induction method is employed for this purpose. Common members of sequences of coefficients are derived from the solution of linear recurrence equations made using Maple operators.
Results. Solutions, obtained for three types of loads, are polynomial in terms of the number of panels. To illustrate the solutions and their qualitative analysis, curves describing the dependence of deflection on the number of panels are made. The author identified the quadratic asymptotics of the solution with respect to the number of panels. The quadratic asymptotics is linear in height.
Conclusions. Formulas are obtained for calculating deflection and reactions of covering supports having an arbitrary number of panels and dimensions if exposed to three types of loads. The presence of extremum points on solution curves is shown. The dependences, identified by the author, are designated both for evaluating the accuracy of numerical solutions and for solving problems of structural optimization in terms of rigidity.
Technology of self-healing road pavements: current status and development prospects
Authors: Inozemtcev Sergei S. , Do Toan Trong  
Published: October 2020

Introduction. Presently, there exists no unified methodology that could control self-healing properties of materials due to the lack of criteria characterizing the ability of materials to respond to impacts and to cope with adverse effects produced on their properties or structure. All assessment methods applied to self-healing properties of materials are reduced to the calculation of the ratio of relative changes in the value of parameters to be measured. A “self-healing” material is a material capable of initiating liquidation of structural defects, so that the rate of this process could exceed the one of spontaneous propagation of defects, while the resistance of the new structure to operating loads is not lower than the initial one. Development of solutions, capable of implementing this principle, will ensure longer service lives of materials.
Materials and methods. A set of general methods of logical research was applied. These methods are based on the theoretical analysis of process solutions presented in professional editions, information resources maintained by their developers and in mass media, patents, research articles and reports.
Results. The self-healing technology is applicable to asphalt concrete with regard for its structural features and thermoplastic properties. Self-healing means restoration of the structural integrity of physical and chemical bonds by moistening crack surfaces, diffusion of molecules between them, and arbitrary dissipation of molecules to ensure reinforcement. Self-healing process uniformity is attainable by applying the technology of functional agent encapsulation so that it could be added to the mix along with other components at the stage of the asphalt concrete mix preparation.
Conclusions. Existing technological solutions can generate capsules that contain the recovery agent in the amount of up to 90…94 % of the total volume. General requirements and quality standards that apply to self-healing materials, used in construction, must be developed to identify their efficiency depending on application conditions. Provisions of the adhesion theory can be applied to the self-healing technology in the course of its implementation.
The study was funded by the grant from the Russian Science Foundation (Project No. 19-79-00262).
A study of the dust content in the air of the urban environment
Authors: Phan Thi An  , Shukurov Ilkhomzhon S. , Pham Van Luong  , Shukurova Lola I. 
Published: October 2020

Introduction. Hanoi is the capital of the Socialist Republic of Vietnam. Hanoi grows according to the following pattern: its central district has several satellites (5 cities) that are accessible by transport systems such as railways, motorways, waterways, etc. Air quality gets worse due to the growing number of urban residents, their personal vehicles, industrial development and other sources of emissions, and each of these factors has a great impact on human health and the state of the environment.
Materials and methods. This study uses PM2.5 data generated by two automatic air monitoring stations located in the northern centre for environmental monitoring of the Environmental Protection Agency of Vietnam and the US Embassy in Vietnam. Methods of statistical assessment and analysis were applied to evaluate the difference in PM2.5 dust concentration at different stages of urban development.
Results. The problem of PM2.5 pollution in Vietnam is particularly relevant, because it threatens public health. In residential areas located in urban neighborhoods notorious for heavy traffic and industrial enterprises, pollution levels still exceed admissible QCVN limits. On the contrary, air pollution is lower in suburban residential areas.
Conclusions. The paper discusses the consequences of environmental pollution, caused by PM2.5 fine dust as a result of urbanization in Hanoi, and analyses urban planning solutions aimed at pollution reduction.