bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viruses and esophageal cancer
Authors: Chang Carolyn , Worrell Stephanie G 
Published: May 2020

Summary
Esophageal adenocarcinoma (EAC) has had the fastest increasing incidence of any solid tumor in the United States in the last 30 years. Long standing gastroesophageal reflux disease is a well-established risk factor with strong associations with obesity, alcohol and tobacco. However, there are likely additional contributing factors. Viruses such as human papillomavirus, ebstein-barr virus and herpes simplex virus have been implicated in the pathogenesis of esophageal cancer. This review will discuss the known literature linking viruses to esophageal adenocarcinoma and consider future relationships such as identifying prognostic and predictive molecular biomarkers to guide therapies.
Pregnancy-associated arterial dissections: a nationwide cohort study
Authors: Beyer Sebastian E , Dicks Andrew B , Shainker Scott A , Feinberg Loryn , Schermerhorn Marc L , Secemsky Eric A , Carroll Brett J 
Published: May 2020

Abstract

Aims
Pregnancy is a known risk factor for arterial dissection, which can result in significant morbidity and mortality in the peripartum period. However, little is known about the risk factors, timing, distribution, and outcomes of arterial dissections associated with pregnancy.

Methods and results
We included all women ≥12 years of age with hospitalizations associated with pregnancy and/or delivery in the Nationwide Readmissions Database between 2010 and 2015. The primary outcome was any dissection during pregnancy, delivery, or the postpartum period (42-days post-delivery). Secondary outcomes included timing of dissection, location of dissection, and in-hospital mortality. Among 18 151 897 pregnant patients, 993 (0.005%) patients were diagnosed with a pregnancy-related dissection. Risk factors included older age (32.8 vs. 28.0 years), multiple gestation (3.6% vs. 1.9%), gestational diabetes (14.3% vs. 0.2%), gestational hypertension (6.0% vs. 0.6%), and pre-eclampsia/eclampsia (2.7% vs. 0.4%), in addition to traditional cardiovascular risk factors. Of the 993 patients with dissection, 150 (15.1%) dissections occurred in the antepartum period, 232 (23.4%) were diagnosed during the admission for delivery, and 611 (61.5%) were diagnosed in the postpartum period. The most common locations for dissections were coronary (38.2%), vertebral (22.9%), aortic (19.8%), and carotid (19.5%). In-hospital mortality was 3.7% among pregnant patients with a dissection vs. &lt;0.001% in patients without a dissection. Deaths were isolated to patients with an aortic (8.6%), coronary (4.2%), or supra-aortic (&lt;2.5%) dissection.

Conclusion
Arterial dissections occurred in 5.5/100 000 hospitalized pregnant or postpartum women, most frequently in the postpartum period, and were associated with high mortality risk. The coronary arteries were most commonly involved. Pregnancy-related dissections were associated with traditional risk factors, as well as pregnancy-specific conditions.
Cumulated and most recent job control and risk of disability pension in the Danish Work Life Course Cohort (DaWCo)
Authors: Framke Elisabeth , Svane-Petersen Annemette Coop , Holm Anders , Burr Hermann , Melchior Maria , Sivertsen Børge , Stansfeld Stephen , Sørensen Jeppe Karl , Virtanen Marianna , Rugulies Reiner , Madsen Ida E H 
Published: May 2020

Abstract

Background
Previous studies have found low job control to be associated with a higher risk of disability pension (DP). Most studies have measured job control only at one time-point, and there is a lack of knowledge regarding the role of exposure duration. This study examines the prospective association between job control and DP measuring exposure both cumulated throughout work life and most recent.

Methods
We included 712 519 individuals (about 4.5 million person-years) from The Danish Work Life Course Cohort which follows young employees in Denmark from their entry into the labour market. Job control was assessed with a job exposure matrix and DP with register data on public transfer payments. We adjusted for several potential life course confounders, including physical demands at work and parental socioeconomic position and psychiatric and somatic diagnoses.

Results
Employees in occupations with low job control had a higher risk of DP. There were effects of both cumulated and most recent job control when mutually adjusted. Fully adjusted hazard ratios (HRs) were 1.14 [95% confidence intervals (CIs) 1.11–1.17] and 1.15 (95% CI 1.02–1.29) for cumulated and most recent job control, respectively. Without mutual adjustment, estimates were 1.15 (95% CI 1.13–1.18) and 1.55 (95% CI 1.39–1.72) for cumulated and most recent low job control, respectively.

Conclusions
Low job control predicts a higher risk of DP, even after adjustment for physical demands at work. The results indicate both gradual and short-term effects of low job control on DP risk.
In Search for a Jurisprudential Justification for the Recognition of a Right of Publicity in Kenya
Authors: Muchiri Moses 
Published: May 2020

Abstract
Publicity rights fall in the intersection between classic intellectual property rights law, unfair trade practices law and privacy rights law. This is an area that has recently witnessed notable judicial decisions in Kenya which have not gained ample exposure and is therefore worth looking into as an area for potential emerging jurisprudence. A look at the existing practices across different jurisdictions in the world reveals various positions and approaches with respect to publicity rights. On one hand, there are jurisdictions in which publicity rights are categorized within the broad spectrum of personality rights, while in other jurisdictions these rights are treated as proprietary rights. Some jurisdictions also take a hybrid approach that amalgamates both proprietary and personality rights approaches. Publicity rights cut across four broad legal areas: tort, property, privacy and unfair trade practice law. These rights also have common similarities with copyright and trademark rights, although they are not synonymous. A significant number of countries which recognize a right of publicity have a mixture of elements of these areas, either as a form of common law approach based on the tort of passing off, or specific statutory enactments on publicity rights. Legal practice and development in each jurisdiction must be considered in the knowledge that each country has developed specific publicity rights mechanisms in response to the socio-economic needs and realities existing in its particular jurisdiction. This study surveys the legal landscape with respect to development of personality rights in Kenya. It also takes a brief look at several other select jurisdictions in an attempt to answer the question whether there is a jurisprudential justification for the recognition of a publicity right in Kenya.
Remembering 1807: Lessons from the Archives
Authors: Oldfield John , Wills Mary 
Published: May 2020

Abstract
This article offers new perspectives on the commemorative events organized around the UK in 2007 to mark the bicentenary of the Abolition of the Slave Trade Act (1807). Drawing from the resources contained in Remembering 1807, a digital archive of information about nearly 350 events and exhibitions held in 2007, it offers a closer look at the variety, diversity and creativity of projects organized by heritage organizations and community groups from all parts of the UK. While agreeing that much of the national narrative focused on the celebratory aspects of Britain’s role in abolition, we argue that many other projects gave voice to a wide range of concerns relating to transatlantic slavery, challenging participants to rethink the boundaries of slavery and abolition in Britain’s public history. This included highlighting the role of transatlantic slavery in hitherto unexplored areas of British history, in local stories and in broader narratives of Britain’s commercial, military, and imperial expansion. Other projects drew attention to the lasting legacies of slavery, emphasized stories of resistance or celebrated the Black presence in Britain. Recognizing these other perspectives within the commemorative impulse in 2007 can help us to (re)orientate future memory work around Britain’s role in transatlantic slavery.
Synovial Pit of the femoral neck: a rare disease with rare presentations
Authors: Amjad Ali , Hafez Ahmed Tarek , Nawab Ditta Adeel , Jan Waqar 
Published: May 2020

AbstractHerniation pits are small benign oval lesions that were reported to be always lying within the super-lateral femoral neck, and were first described in 1982 by Michael J. Pitt. They are usually a unilateral incidental finding along with asymptomatic course. It was widely believed that herniation pits are a result of invagination of the overlying synovium into small cortical defects in the femoral neck. In our case; the mentioned lesions were found atypically bilaterally at the inferomedial aspect of the neck of femur of a 7-year old child. Radiological scans were efficient to obtain an adequate diagnosis whereas conservative management proved to be sufficient dealing with the lesions. Synovial pits may have atypical clinical and radiological course, and this can raise concerns especially with symptomatic hip that may encourage surgical interventions. However, due to benign course of these lesions, we do not recommend any surgical intervention for such lesions.
X-ray irradiation and evaporation of the four young planets around V1298 Tau
Authors: Poppenhaeger K , Ketzer L , Mallonn M 
Published: May 2020

ABSTRACT
Planets around young stars are thought to undergo atmospheric evaporation due to the high magnetic activity of the host stars. Here we report on X-ray observations of V1298 Tau, a young star with four transiting exoplanets. We use X-ray observations of the host star with Chandra and ROSAT to measure the current high-energy irradiation level of the planets and employ a model for the stellar activity evolution together with exoplanetary mass-loss to estimate the possible evolution of the planets. We find that V1298 Tau is X-ray bright with log LX [erg s−1] = 30.1 and has a mean coronal temperature of ≈9 MK. This places the star amongst the more X-ray luminous ones at this stellar age. We estimate the radiation-driven mass-loss of the exoplanets and find that it depends sensitively on the possible evolutionary spin-down tracks of the star as well as on the current planetary densities. Assuming the planets are of low density due to their youth, we find that the innermost two planets can lose significant parts of their gaseous envelopes and could be evaporated down to their rocky cores depending on the stellar spin evolution. However, if the planets are heavier and follow the mass–radius relation of older planets, then even in the highest XUV irradiation scenario none of the planets is expected to cross the radius gap into the rocky regime until the system reaches an age of 5 Gyr.
Internal kinematics of giant H ii regions in M101 with the Keck Cosmic Web Imager
Authors: Bresolin Fabio , Rizzi Luca , Ho I-Ting , Terlevich Roberto , Terlevich Elena , Telles Eduardo , Chávez Ricardo , Basilakos Spyros , Plionis Manolis 
Published: May 2020

ABSTRACT
We study the kinematics of the giant H ii regions NGC 5455 and NGC 5471 located in the galaxy M101, using integral field observations that include the H β and [O iii]$\, \lambda$ 5007 emission lines, obtained with the Keck Cosmic Web Imager. We analyse the line profiles using both single and multiple Gaussian curves, gathering evidence for the presence of several expanding shells and moving filaments. The line decomposition shows that a broad (σ ≃ 30–50 km s−1) underlying component is ubiquitous, extending across hundreds of pc, while a large fraction of the narrow components have subsonic line widths. The supersonic turbulence inferred from the global line profiles is consistent with the velocity dispersion of the individual narrow components, i.e. the global profiles likely arise from the combined contribution of discrete gas clouds. We confirm the presence of very extended (400–1200 km s−1) low-intensity line components in three bright star-forming cores in NGC 5471, possibly representing kinematic signatures of supernova remnants. For one of these, the known supernova remnant host NGC 5471 B, we find a significantly reduced [O iii]/H β line ratio relative to the surrounding photoionized gas, due to the presence of a radiative shock at low metallicity. We explore the systematic width discrepancy between H i and [O iii] lines, present in both global and individual spaxel spectra. We argue that the resolution of this long-standing problem lies in the physics of the line-emitting gas rather than in the smearing effects induced by the different thermal widths.
Measuring the local dark matter density with LAMOST DR5 and Gaia DR2
Authors: Guo Rui , Liu Chao , Mao Shude , Xue Xiang-Xiang , Long R J , Zhang Lan 
Published: May 2020

ABSTRACT
We apply the vertical Jeans equation to the kinematics of Milky Way stars in the solar neighbourhood to measure the local dark matter density. More than 90 000 G- and K-type dwarf stars are selected from the cross-matched sample of LAMOST (Large Sky Area Multi-Object Fibre Spectroscopic Telescope) fifth data release and Gaia second data release for our analyses. The mass models applied consist of a single exponential stellar disc, a razor thin gas disc, and a constant dark matter density. We first consider the simplified vertical Jeans equation that ignores the tilt term and assumes a flat rotation curve. Under a Gaussian prior on the total stellar surface density, the local dark matter density inferred from Markov chain Monte Carlo simulations is $0.0133_{-0.0022}^{+0.0024}\ {\rm M}_{\odot }\, {\rm pc}^{-3}$. The local dark matter densities for subsamples in an azimuthal angle range of −10° &lt; ϕ &lt; 5° are consistent within their 1σ errors. However, the northern and southern subsamples show a large discrepancy due to plateaux in the northern and southern vertical velocity dispersion profiles. These plateaux may be the cause of the different estimates of the dark matter density between the north and south. Taking the tilt term into account has little effect on the parameter estimations and does not explain the north and south asymmetry. Taking half of the difference of σz profiles as unknown systematic errors, we then obtain consistent measurements for the northern and southern subsamples. We discuss the influence of the vertical data range, the scale height of the tracer population, the vertical distribution of stars, and the sample size on the uncertainty of the determination of the local dark matter density.
Astrometry and infrared observations of the Mira variable stars AP Lyncis, V837 Herculis, and BX Camelopardalis: Implications for the period–luminosity relation of the Milky Way
Authors: Chibueze James O , Urago Riku , Omodaka Toshihiro , Morikawa Yuto , Fujimoto Masayuki Y , Nakagawa Akiharu , Nagayama Takahiro , Nagayama Takumi , Hirano Ken 
Published: May 2020

Abstract
AP Lyn and V837 Her are long-period Mira variable stars in the Milky Way. We performed VLBI Exploration of Radio Astrometry (VERA) phase-referenced observations towards H2O masers associated with AP Lyn and V837 Her. The annual parallaxes of AP Lyn and V837 Her were obtained to be 2.008 ± 0.038 mas and 1.090 ± 0.014 mas, corresponding to distances of 498 ± 10 pc and 917 ± 12 pc, respectively. From our multi-epoch infrared observations using the Kagoshima University 1 m telescope, we derived the mean J-, H-, and K′-band magnitudes of AP Lyn, V837 Her, and an additional long-period Mira variable BX Cam, whose parallax is known. We derived their pulsation periods to be 433 ± 1 d, 520 ± 1 d, and 458 ± 1 d, respectively, using the K′-band light curves. The MK–log P relation of long-period Mira variables seem to be violated by Mira variable stars with larger-than-expected MK values (like OZ Gem) in the Milky Way because of circumstellar extinction leading to an observed dimming effect. AP Lyn, V837 Her, and BX Cam (like OZ Gem) are dimming from the trend to O-rich stars in the Large Magellanic Cloud. This implies that the high metallicity of the Milky Way galaxy increases the opacity of the Mira-type variable stars and strengthens mass loss.
‘The Empire of England’: Enoch Powell, Sovereignty, and the Constitution of the Nation
Authors: Aqui Lindsay , Kenny Michael , Pearce Nick 
Published: May 2020

Abstract
The 50th anniversary of Enoch Powell’s ‘Rivers of Blood’ speech brought back into public debate one of the most controversial figures in modern British political history. Powell remains indelibly linked to the stances he took on race and immigration in the 1960s and 1970s, but in recent years there has been a widening of the lens through which his politics and public arguments are viewed. This article contributes to this reappraisal, arguing that central aspects of his thinking were shaped by his highly distinctive reflections on sovereignty, representation, and the nation state in the early 1950s. It demonstrates that Powell’s positions on both the internal configuration of the nation state and its external relations were intertwined, and were applied by him on a fairly consistent basis throughout his career, informing the stances he took on the contentious issues of Europe and Ulster in the 1970s, as well as immigration. Our account of his thinking challenges both the tendency of his interpreters to treat his views on international relations and the internal politics of the United Kingdom as thematically distinct, and the accusation of political opportunism that has been a central motif in commentary on his political career.
Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes
Authors: Zajac Lauren , Koo Bang-Bon , Tripodis Yorghos , Mian Asim , Steinberg Eric , Mez Jesse , Alosco Michael L , Cervantes-Arslanian Anna , Stern Robert , Killiany Ronald 
Published: May 2020

Abstract
The goal of this study was to examine whether hippocampal volume or resting-state functional connectivity (rsFC) patterns are associated with subjective memory decline (SMD) in cognitively normal aged adults. Magnetic resonance imaging data from 53 participants (mean age: 71.9 years) of the Boston University Alzheimer’s Disease Center registry were used in this cross-sectional study. Separate analyses treating SMD as a binary and continuous variable were performed. Subfield volumes were generated using FreeSurfer v6.0, and rsFC strength between the head and body of the hippocampus and the rest of the brain was calculated. Decreased left whole hippocampal volume and weaker rsFC strength between the right body of the hippocampus and the default mode network (DMN) were found in SMD+. Cognitive Change Index score was not correlated with volumetric measures but was inversely correlated with rsFC strength between the right body of the hippocampus and 6 brain networks, including the DMN, task control, and attentional networks. These findings suggest that hippocampal rsFC patterns reflect the current state of SMD in cognitively normal adults and may reflect subtle memory changes that standard neuropsychological tests are unable to capture.
Evaluating the Outcomes of an Organizational Initiative to Expand End-of-Life Resources in Intensive Care Units With Palliative Support Tools and Floating Hospice
Authors: McAndrew Natalie S. , McCracken Colleen , Szabo Aniko , Narayanan Balaji , Peltier Wendy , Leske Jane 
Published: May 2020

Background
There is evidence that palliative care and floating (inpatient) hospice can improve end-of-life experiences for patients and their families in the intensive care unit (ICU). However, both palliative care and hospice remain underutilized in the ICU setting.

Objectives
This study examined palliative consultations and floating hospice referrals for ICU patients during a phased launch of floating hospice, 2 palliative order sets, and general education to support implementation of palliative care guidelines.

Methods
This descriptive, retrospective study was conducted at a level I trauma and academic medical center. Electronic medical records of 400 ICU patients who died in the hospital were randomly selected. These electronic medical records were reviewed to determine if patients received a palliative consult and/or a floating hospice referral, as well as whether the new palliative support tools were used during the course of care. The numbers of floating hospice referrals and palliative consults were measured over time.

Results
Although not significant, palliative consults increased over time (P = .055). After the initial introduction of floating hospice, 27% of the patients received referrals; however, referrals did not significantly increase over time (P = .807). Of the 68 patients who received a floating hospice referral (24%), only 38 were discharged to floating hospice. There was a trend toward earlier palliative care consults, although this was not statistically significant (P = .285).

Conclusion
This study provided the organization with vital information about their initiative to expand end-of-life resources. Utilization and timing of palliative consults and floating hospice referrals were lower and later than expected, highlighting the importance of developing purposeful strategies beyond education to address ICU cultural and structural barriers.
ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARγ Expression
Authors: Gong Fu-Han , Cheng Wen-Lin , Zhang Quan , Chen Xi-Lu , Cao Jian-Lei , Yang Ting , Song Wen-Hao , Zhao Fang 
Published: May 2020

Abstract:
As a receptor for transforming growth factor-β, nodal and activin, activin receptor–like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. However, the potential effect and molecular mechanism of ALK7 on vascular smooth muscle cells’ (VSMCs) phenotypic modulation have not been investigated. Using cultured mouse VSMCs with platelet-derived growth factor-BB administration, we observed that ALK7 showed a significantly increased expression in VSMCs accompanied by decreased VSMCs differentiation marker genes. Loss-of-function study demonstrated that ALK7 knockdown inhibited platelet-derived growth factor-BB–induced VSMCs phenotypic modulation characterized by increased VSMCs differentiation markers, reduced proliferation, and migration of VSMCs. Such above effects were reversed by ALK7 overexpression. Notably, we noticed that ALK7 silencing dramatically enhanced PPARγ expression, which was required for the attenuated effect of ALK7 knockdown on VSMCs phenotypic modulation. Collected, we identified that ALK7 acted as a novel and positive regulator for VSMCs phenotypic modulation partially through inactivation of PPARγ, which suggested that neutralization of ALK7 might act as a promising therapeutic strategy of intimal hyperplasia.