bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microstructure Evolution During Hot Deformation of REX734 Austenitic Stainless Steel
Authors: Kulakov Mykola , Huang Jianglin , Ntovas Michail , Moturu Shanmukha 
Published: December 2019

Abstract
Mechanical properties of a REX734 austenitic stainless steel were examined through compression testing over a wide range of temperatures (1173 K to 1373 K (900 °C to 1100 °C)) and strain rates (0.1 to 40 s−1) that cover deformation conditions encountered in different metalworking processes. The evolution of microstructure was studied using electron microscopy combined with electron backscatter diffraction and energy-dispersive spectroscopy. Partially recrystallized microstructures were obtained after compression testing at 1173 K (900 °C), while after deformation at 1273 K and 1373 K (1000 °C and 1100 °C), the material was fully recrystallized almost in all examined cases. The role of dynamic and metadynamic restoration processes in the formation of final microstructure was investigated. Σ3 twin boundaries lost their twin character and transformed into general high-angle grain boundaries as a result of deformation, while during recrystallization new Σ3 twin boundaries formed. The evolution of precipitates during compression testing and their role in the recrystallization process was also discussed.
High Purity Nickel Recovery from an Industrial Sidestream Using Concentration and Liquid–Liquid Extraction Techniques
Authors: Hu Fang , Wilson Benjamin P. , Han Bing , Zhang Jianxin , Louhi-Kultanen Marjatta , Lundström Mari 
Published: December 2019

AbstractThis article outlines an alternative flowsheet for the purification of a multi-metal industrial sidestream (16.3 g/l Ni, 0.7 g/l Co, 0.6 g/l Ca and 1.6 g/l Mg) to allow high-purity nickel recovery. The methodology comprises an initial evaporation step to achieve Ca removal followed by impurity (Ca, Mg) and valuable (Co, Ni) element separation via two-step solvent extraction with organophosphorus extractants. Results indicate that > 80% of Ca is selectively removed as CaSO4·2H2O by evaporation with a concentration degree > 6. In the following treatment, ~ 90% of residual Ca (0.6 g/l) can be selectively extracted with Na-D2EHPA. The subsequent solvent extraction step with Na-Cyanex 272 separates Co (> 99%) and Mg (> 95%). The resultant nickel sulfate solution (61.7 g/l Ni, 0.3 g/l Mg and Co 0.007 g/l) of > 99.5% purity can be directly integrated into state-of-the-art nickel recovery processes.
Proteinkomplexe an inhibitorischen Synapsen in psychiatrischen Störungen
Authors: Krueger-Burg Dilja 
Published: December 2019

AbstractOrganizational protein complexes at inhibitory postsynapses in the brain play a key role in regulating the flow of information through neuronal networks, and accordingly, abnormalities in these complexes can contribute to the pathophysiology of psychiatric disorders. Recent research indicates that the molecular composition of these complexes is highly diverse and synapse-specific, posing major challenges for basic research but also offering opportunities for potential clinical applications.
Small-Molecule Protein Kinases Inhibitors and the Risk of Fungal Infections
Authors: Bechman Katie , Galloway James B , Winthrop Kevin L 
Published: December 2019

AbstractPurpose of ReviewThis review discusses fungal infections associated with licenced small-molecule protein kinase inhibitors. For each major drug class, the mechanism of action and targeted pathways and the impact on host defence against fungi are described.Recent FindingsProtein kinase inhibitors are successfully used in the treatment of malignancies and immune-mediated diseases, targeting signalling pathways for a broad spectrum of cytokines and growth-stimuli. These agents predispose to fungal infections by the suppression of integral components of the adaptive and innate immune response.SummaryThe greatest risk of fungal infections is seen with bruton tyrosine kinase inhibitors, e.g. ibrutinib. Infections are also reported with agents that target mTOR, Janus kinase and break point cluster (Bcr) gene–Abelson (Abl) tyrosine kinase (BCR-ABL). The type of fungal infection fits mechanistically with the specific pathway targeted. Infections are often disseminated and present soon after the initiation of therapy. The pharmacokinetic profile, possibility of off-target kinase inhibition, and underlying disease pathology contribute to infection risk.
A model-based exploration of farm-household livelihood and nutrition indicators to guide nutrition-sensitive agriculture interventions
Authors: Estrada-Carmona Natalia , Raneri Jessica E. , Alvarez Stephanie , Timler Carl , Chatterjee Shantonu Abe , Ditzler Lenora , Kennedy Gina , Remans Roseline , Brouwer Inge , den Berg Karin Borgonjen-van , Talsma Elise F. , Groot Jeroen C. J. 
Published: December 2019

AbstractAssessing progress towards healthier people, farms and landscapes through nutrition-sensitive agriculture (NSA) requires transdisciplinary methods with robust models and metrics. Farm-household models could facilitate disentangling the complex agriculture-nutrition nexus, by jointly assessing performance indicators on different farm system components such as farm productivity, farm environmental performance, household nutrition, and livelihoods. We, therefore, applied a farm-household model, FarmDESIGN, expanded to more comprehensively capture household nutrition and production diversity, diet diversity, and nutrient adequacy metrics. We estimated the potential contribution of an NSA intervention targeting the diversification of home gardens, aimed at reducing nutritional gaps and improving livelihoods in rural Vietnam. We addressed three central questions: (1) Do ‘Selected Crops’ (i.e. crops identified in a participatory process) in the intervention contribute to satisfying household dietary requirements?; (2) Does the adoption of Selected Crops contribute to improving household livelihoods (i.e. does it increase leisure time for non-earning activities as well as the dispensable budget)?; and (3) Do the proposed nutrition-related metrics estimate the contribution of home-garden diversification towards satisfying household dietary requirements? Results indicate trade-offs between nutrition and dispensable budget, with limited farm-household configurations leading to jointly improved nutrition and livelihoods. FarmDESIGN facilitated testing the robustness and limitations of commonly used metrics to monitor progress towards NSA. Results indicate that most of the production diversity metrics performed poorly at predicting desirable nutritional outcomes in this modelling study. This study demonstrates that farm-household models can facilitate anticipating the effect (positive or negative) of agricultural interventions on nutrition and the environment, identifying complementary interventions for significant and positive results and helping to foresee the trade-offs that farm-households could face. Furthermore, FarmDESIGN could contribute to identifying agreed-upon and robust metrics for measuring nutritional outcomes at the farm-household level, to allow comparability between contexts and NSA interventions.
Influence of HfO2 alloying effect on microstructure and thermal conductivity of HoTaO4 ceramics
Authors: Chen Lin , Feng Jing 
Published: December 2019

AbstractHfO2 alloying effect has been applied to optimize thermal insulation performance of HoTaO4 ceramics. X-ray diffraction, Raman spectroscopy, and X-ray photoelectron spectroscopy are employed to decide the crystal structure. Scanning electronic microscopy is utilized to detect the influence of HfO2 alloying effect on microstructure. Current paper indicates that the same numbers of Ta5+ and Ho3+ ions of HoTaO4 are substituted by Hf4+ cations, and it is defined as alloying effect. No crystal structural transition is introduced by HfO2 alloying effect, and circular pores are produced in HoTaO4. HfO2 alloying effect is efficient in decreasing thermal conductivity of HoTaO4 and it is contributed to the differences of ionic radius and atomic weight between Hf4+ ions and host cations (Ta5+ and Ho3+). The least experimental thermal conductivity is 0.8 W·K−1·m−1 at 900 °C, which is detected in 6 and 9 mol%-HfO2 HoTaO4 ceramics. The results imply that HfO2–HoTaO4 ceramics are promising thermal barrier coatings (TBCs) due to their extraordinary thermal insulation performance.
PZT–NZF/CF ferrite flexible thick films: Structural, dielectric, ferroelectric, and magnetic characterization
Authors: Bobić J. D. , Teixeira G. Ferreira , Grigalaitis R. , Gyergyek S. , Petrović M. M. Vijatović , Zaghete M. Ap. , Stojanovic B. D. 
Published: December 2019

AbstractThe preparation and properties of thick flexible three-phase composite films based on lead zirconium titanate (PZT) and various ferrites (nickel zinc ferrite (NZF) and cobalt ferrite (CF)) were reported in this study. Properties of three-phase composite films were compared with pure polyvinylidene fluoride (PVDF) and PZT–PVDF films. X-ray diffraction data indicated the formation of well crystallized structure of PZT and NZF/CF phases, without the presence of undesirable phases. Scanning electron micrographs showed that the ceramic particles were dispersed homogeneously in the PVDF matrix and atomic force microscopy confirmed that the size of the particles is around 30 nm. Non-saturated hysteresis loops were evident in all samples due to the presence of highly conductive ferrite phases. Under magnetic field of 10 kOe, composite films exhibited a typical ferromagnetic response. Dielectric properties were investigated in the temperature range from −128 to 250 °C and frequency range of 400 Hz–1 MHz. The results showed that the value of dielectric constant of the PVDF/PZT/ferrite composites increased about 25% above the one obtained for pure PVDF.
Additive manufacturing with the lightweight material aluminium alloy EN AW-7075
Authors: Langebeck Anika , Bohlen Annika , Freisse Hannes , Vollertsen Frank 
Published: December 2019

AbstractAs a widely used additive manufacturing technique, the laser metal deposition process (LMD) also known as direct energy deposition (DED) is often used to manufacture large-scale parts. Advantages of the LMD process are the high build-up rate as well as its nearly limitless build-up volume. To manufacture large-scale parts in lightweight design with high strength aluminium alloy EN AW-7075, the LMD process has a disadvantage that must be considered. During the process, the aluminium alloy is melted and has therefore a high solubility for hydrogen. As soon as the melt pool solidifies again, the hydrogen cannot escape the melt and hydrogen pores are formed which weakens the mechanical properties of the manufactured part. To counter this disadvantage, the hydrogen must be successfully kept away from the process zone. Therefore, the covering of the process zone with shielding gas can be improved by an additional shielding gas shroud. Furthermore, the process parameters energy input per unit length as well as the horizontal overlapping between two single tracks can be varied to minimize the pore volume. Best results can be achieved in single tracks with an elevated energy input per unit length from 3000 to 6000 J/cm. To manufacture layers, a minimal horizontal overlapping will lead to lowest pore volume, although this results in a very wavy surface, as a compromise of low pore volume and a nearly even surface a horizontal overlapping of 30 to 37% leads to a pore volume of 0.95% ± 0.50%.
Is Motorized Treadmill Running Biomechanically Comparable to Overground Running? A Systematic Review and Meta-Analysis of Cross-Over Studies
Authors: Van Hooren Bas , Fuller Joel T. , Buckley Jonathan D. , Miller Jayme R. , Sewell Kerry , Rao Guillaume , Barton Christian , Bishop Chris , Willy Richard W. 
Published: December 2019

Abstract
Background
Treadmills are often used in research, clinical practice, and training. Biomechanical investigations comparing treadmill and overground running report inconsistent findings.

Objective
This study aimed at comparing biomechanical outcomes between motorized treadmill and overground running.

Methods
Four databases were searched until June 2019. Crossover design studies comparing lower limb biomechanics during non-inclined, non-cushioned, quasi-constant-velocity motorized treadmill running with overground running in healthy humans (18–65 years) and written in English were included. Meta-analyses and meta-regressions were performed where possible.

Results
33 studies (n = 494 participants) were included. Most outcomes did not differ between running conditions. However, during treadmill running, sagittal foot–ground angle at footstrike (mean difference (MD) − 9.8° [95% confidence interval: − 13.1 to − 6.6]; low GRADE evidence), knee flexion range of motion from footstrike to peak during stance (MD 6.3° [4.5 to 8.2]; low), vertical displacement center of mass/pelvis (MD − 1.5 cm [− 2.7 to − 0.8]; low), and peak propulsive force (MD − 0.04 body weights [− 0.06 to − 0.02]; very low) were lower, while contact time (MD 5.0 ms [0.5 to 9.5]; low), knee flexion at footstrike (MD − 2.3° [− 3.6 to − 1.1]; low), and ankle sagittal plane internal joint moment (MD − 0.4 Nm/kg [− 0.7 to − 0.2]; low) were longer/higher, when pooled across overground surfaces. Conflicting findings were reported for amplitude of muscle activity.

Conclusions
Spatiotemporal, kinematic, kinetic, muscle activity, and muscle–tendon outcome measures are largely comparable between motorized treadmill and overground running. Considerations should, however, particularly be given to sagittal plane kinematic differences at footstrike when extrapolating treadmill running biomechanics to overground running. Protocol registration CRD42018083906 (PROSPERO International Prospective Register of Systematic Reviews).
Fact-checking strategies to limit urban legends spreading in a segregated society
Authors: Tambuscio Marcella , Ruffo Giancarlo 
Published: December 2019

AbstractWe propose a framework to study the spreading of urban legends, i.e., false stories that becomepersistentin a local popular culture, where social groups are naturally segregated by virtue of many (both mutable and immutable) attributes. The goal of this work is identifying and testing newstrategiesto restrain the dissemination of false information, focusing on the role of network polarization. Following the traditional approach in the study of information diffusion, we consider an epidemic network-based model where the agents can be ‘infected’ after being exposed to the urban legend or to its debunking depending on the belief of their neighborhood. Simulating the spreading process on several networks showing different kind of segregation, we perform awhat-if analysisto compare strategies and to understand where it is better to locateeternal fact-checkers, nodes that maintain their position as debunkers of the given urban legend. Our results suggest that very few of these strategies have a chance to succeed. This apparently negative outcomes turns out to be somehow surprising taking into account that we ran our simulations under a highly pessimistic assumption, such that the ‘believers’, i.e., agents that accepted as true the urban legend after they have been exposed to it, will not change their belief no matter of how much external or internal additional informational sources they access to. This has implications on policies that are supposed to decide which strategy to apply to stop misinformation from spreading in real world networks.
Association Among Lower Urinary Tract Symptoms, Erectile Function, and Sexual Satisfaction: Results from the Brazil LUTS Study
Authors: Gomes Cristiano Mendes , Averbeck Marcio Augusto , Koyama Mitti , Soler Roberto 
Published: December 2019

Abstract

Introduction
Lower urinary tract symptoms (LUTS) affect ≥60% of adult men and are associated with erectile dysfunction (ED) and sexual dissatisfaction.

Aim
The aim of this study was to evaluate the relationship among male LUTS, ED, and sexual satisfaction.

Methods
This was a secondary analysis of the Brazil LUTS study, a cross-sectional, epidemiological survey conducted by telephone interview in 5 cities in Brazil. This analysis included men aged ≥40 years.

Main Outcome Measure
LUTS were identified using International Continence Society definitions. LUTS severity was assessed using the International Prostate Symptom Score questionnaire. Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5) questionnaire and sexual satisfaction was rated on a 5-point scale.

Results
2,433 men participated in the study. Of 2,183 men reporting data on LUTS, 873 (40%) had LUTS “about half the time” or more. The prevalence of ED and sexual dissatisfaction was 14.4% and 7.8%, respectively. The proportion of men reporting ED and sexual dissatisfaction was higher among men with LUTS (24.6% and 13.8%, respectively) than men without LUTS (8.7% and 4.5%, respectively; P &lt; .001). LUTS severity was negatively correlated with IIEF-5 scores (r = –0.199; P &lt; .001); we estimated a 0.431-point decrease in IIEF-5 score per 3-point increase in International Prostate Symptom Score. Increased age and the presence of LUTS were associated with a greater chance of ED and sexual dissatisfaction; depression/anxiety and diabetes were associated with a greater chance of sexual dissatisfaction only. Among men with LUTS, urgency with fear of leaking, urgency urinary incontinence, and nocturnal enuresis were associated with a greater chance of ED, whereas slow stream and urgency urinary incontinence were associated with a greater chance of sexual dissatisfaction.

Conclusion
These results demonstrate that the presence of LUTS is associated with an increased chance of ED and sexual dissatisfaction in Brazilian men and reinforce the importance of a comprehensive assessment of these conditions.
Machine Learning to Detect Alzheimer’s Disease from Circulating Non-Coding RNAs
Authors: Ludwig Nicole , Fehlmann Tobias , Kern Fabian , Gogol Manfred , Maetzler Walter , Deutscher Stephanie , Gurlit Simone , Schulte Claudia , von Thaler Anna-Katharina , Deuschle Christian , Metzger Florian , Berg Daniela , Suenkel Ulrike , Keller Verena , Backes Christina , Lenhof Hans-Peter , Meese Eckart , Keller Andreas 
Published: December 2019

Abstract
Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures. These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches. Previously, we published high-throughput sequencing based microRNA (miRNA) signatures in Alzheimer’s disease (AD) patients in the United States (US) and Germany. Here, we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR. We computed models to assess the relation between miRNA expression and phenotypes, gender, age, or disease severity (Mini-Mental State Examination; MMSE). Of the 21 miRNAs, expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts. 18 miRNAs were significantly correlated with neurodegeneration (Benjamini-Hochberg adjusted P &lt; 0.05) with highest significance for miR-532-5p (Benjamini-Hochberg adjusted P = 4.8 × 10−30). Machine learning models reached an area under the curve (AUC) value of 87.6% in differentiating AD patients from controls. Further, ten miRNAs were significantly correlated with MMSE, in particular miR-26a/26b-5p (adjusted P = 0.0002). Interestingly, the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells, while those up-regulated in AD were enriched in serum, exosomes, cytotoxic t-cells, and B-cells. Our study represents the next important step in translational research for a miRNA-based AD test.
Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study
Authors: Jensen Caroline , Dale Hanna F. , Hausken Trygve , Lied Einar , Hatlebakk Jan G. , Brønstad Ingeborg , Lied Gülen A. , Hoff Dag Arne L. 
Published: December 2019

Abstract
A large proportion of older adults are affected by impaired glucose metabolism. Previous studies with fish protein have reported improved glucose regulation in healthy adults, but the evidence in older adults is limited. Therefore, we wanted to assess the effect of increasing doses of a cod protein hydrolysate (CPH) on postprandial glucose metabolism in older adults. The study was a double-blind cross-over trial. Participants received four different doses (10, 20, 30 or 40 mg/kg body weight (BW)) of CPH daily for 1 week with 1-week washout periods in between. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose and insulin in 20 min intervals for 120 min. The secondary outcome was postprandial response in plasma glucagon-like peptide 1 (GLP-1). Thirty-one subjects aged 60–78 years were included in the study. In a mixed-model statistical analysis, no differences in estimated maximum value of glucose, insulin or GLP-1 were observed when comparing the lowest dose of CPH (10 mg/kg BW) with the higher doses (20, 30 or 40 mg/kg BW). The estimated maximum value of glucose was on average 0·28 mmol/l lower when the participants were given 40 mg/kg BW CPH compared with 10 mg/kg BW (P = 0·13). The estimated maximum value of insulin was on average 5·14 mIU/l lower with 40 mg/kg BW of CPH compared with 10 mg/kg BW (P = 0·20). Our findings suggest that serum glucose and insulin levels tend to decrease with increasing amounts of CPH. Due to preliminary findings, the results require further investigation.
Phylogenetic relationships between genera Dorcadion, Lamia, Morimus, Herophila and some other Lamiinae (Coleoptera: Cerambycidae) based on chromosome and CO1 gene sequence comparison
Authors: Giannoulis Themis , Dutrillaux Anne-Marie , Sarri Constantina , Mamuris Zissis , Dutrillaux Bernard 
Published: December 2019

AbstractA dual molecular and cytogenetic study was performed with the aim to improve the controversial systematic classification of some species of Lamiinae (Coleoptera: Cerambycidae). The karyotypes of species belonging to genera Morimus, Herophila, Dorcadion, Neodorcadion and Lamia share a number of characters, which differentiate them from other species, belonging to genera Phytoecia, Parmena and Monochamus. The karyotypes of the last three species comprise 20 chromosomes, mostly metacentric or sub-metacentric, as in the presumed Cerambycidae ancestors. The karyotypes of the former species share many characters derived from the Lamiinae ancestors by a number of chromosome fissions and inversions indicating their monophyly. Comparisons of the CO1 gene sequence also show the monophyly of Morimus, Lamia, Herophila and Dorcadion and their distant relationship with others. These convergent results allow us to propose a phylogenetic classification of these genera, which places the monospecific genus Lamia close to Dorcadion, clearly separates Dorcadion and Neodorcadion and places Herophila closer to Morimus than to Dorcadion/Lamia. The genus Morimus is the most derived. CO1 mutations loosely separate the forms M. asper and M. funereus, which have similar karyotypes and behaviour and copulate in captivity. The form M. ganglebaueri may have a funereus X asper hybrid origin.
RECONCEPTUALISING THE LEGAL RESPONSE TO FOREIGN FIGHTERS
Authors: Ip John 
Published: December 2019

AbstractThe Syrian civil war has highlighted the phenomenon of foreign fighting, in which individuals leave their home State to join an armed conflict overseas. The predominant paradigm for regulating foreign fighting, centred on United Nations Security Council Resolution 2178, is based on counterterrorism, which in essence treats foreign fighting as a form of terrorism. This paradigm is largely reflective of the domestic legislation of the United Kingdom, United States, Canada and Australia. This article argues that this approach is problematic, and that an alternative paradigm based on the international law of neutrality and related domestic legislation provides a better means for regulating foreign fighting.