bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the peri-implant bone trabecular microstructure changes in short implants with fractal analysis
Authors: Kış Hatice Cansu , Güleryüz Gürbulak Ayşegül 
Published: March 2020

Abstract
Backgrounds
This study aimed to evaluate the microstructural changes in the peri-implant bone in patients with short implants in terms of implant survival status by using fractal analysis measurements.

Results
Dental panoramic radiographs (DPRs) of 67 patients were examined and included in this study. Fractal analysis and measurement of the crown-implant ratio were performed with ImageJ. The fractal analysis measurement was performed on the DPRs obtained at preoperative (FD0) and in the follow-up periods (after 2 ± 2 weeks (FD1), 2 months ± 2 weeks (FD2), 6 months ± 2 weeks (FD3), and 12 months + (FD4)). A p value < 0.05 was considered statistically significant. Power analyses were conducted for the test results that did not reject null hypothesis. A significant difference was found in the FD1 and FD2 values between the implant survival groups (p < 0.001 and p = 0.023, respectively). The mean FD1 and FD2 values of the success group were significantly higher than those of the failure group.

Conclusions
Fractal analysis is a useful method to measure the trabecular microstructure of bone in non-standardized dental radiographs. The present study has a low power to reject the null hypothesis because of the low number of cases of implant failure. Therefore, further study with a large sample size is warranted. In clinical practice, the survival of implants may be predicted by analyzing fractal dimension of the surrounding trabecular bone of the implants.
Application of seismic sedimentology in lithostratigraphic trap exploration: A case study from Banqiao Sag, Bohai Bay Basin, China
Authors: Su Mingjun , Yao Jun , Chen Qilin , Hu Kaifeng , Hong Zhong 
Published: March 2020

A method of identifying lithostratigraphic traps based on seismic sedimentology is proposed. We first establish a 3D high-resolution (fifth-order) sequence stratigraphic framework by using the stratal slices. Then, the reservoir distribution and reservoir-seal assemblage are investigated within the high-resolution sequence framework. This method turns the interpretation of lithostratigraphic traps from traditional seismic facies-based approach to the dynamic analysis of high-resolution seismic geomorphic information. We divide the lower Sha-1 member in the Banqiao Sag, Bohai Bay Basin, East China, into fourth- and fifth-order sequences by applying our method. The fifth-order sequence corresponding to Sha1-2 shows that the fan delta-distal subaqueous fan depositional system can be observed at the bottom of Sha1-2. The bounding fault and paleogeomorphology control the deposition of sand, whereas the sand bodies in the fan delta and distal subaqueous fan are developed near the bounding fault and the open lake basin, respectively. We then predict the sand thickness based on the well logs and seismic amplitudes. Moreover, according to the structural features, at least four lithostratigraphic traps are identified. These traps form a good reservoir-seal assemblage with overlying mudstones deposited during the period of lacustrine level rising. The drilling results in Trap-3 suggest that, our method can be a method of choice for effectively identifying the lithostratigraphic traps, a significant measure for hydrocarbon exploration.
Next-Generation Sequencing of Advanced GI Tumors Reveals Individual Treatment Options
Authors: Bitzer Michael , Ostermann Leonie , Horger Marius , Biskup Saskia , Schulze Martin , Ruhm Kristina , Hilke Franz , Öner Öznur , Nikolaou Konstantin , Schroeder Christopher , Riess Olaf , Fend Falko , Zips Daniel , Hinterleitner Martina , Zender Lars , Tabatabai Ghazaleh , Beha Janina , Malek Nisar P. 
Published: March 2020

PURPOSE Precision oncology connects highly complex diagnostic procedures with patient histories to identify individualized treatment options in interdisciplinary molecular tumor boards (MTBs). Detailed data on MTB-guided treatments and outcome with a focus on advanced GI cancers have not been reported yet. PATIENTS AND METHODS Next-generation sequencing of tumor and normal tissue pairs was performed between April 2016 and February 2018. After identification of relevant molecular alterations, available clinical studies or in-label, off-label, or matched experimental treatment options were recommended. Follow-up data and a response assessment that was based on radiologic imaging were recorded. RESULTS Ninety-six patients were presented to the MTB of Tuebingen University Hospital. Sixteen (17%) showed “pathogenic” or “likely pathogenic” germline variants. Recommendations on the basis of molecular alterations or tumor mutational burden were given for 41 patients (43%). Twenty-five received the suggested drug, and 20 were evaluable for best response assessment. Three patients (15%) reached a partial response (PR), and 6 (30%), stable disease (SD), whereas 11 (55%) had tumor progression (progressive disease). Median progression-free survival (PFS) for all treated and evaluable patients was 2.8 months (range, 1.0-9.0 months), and median overall survival (OS) of all treated patients was 5.2 months (range, 0.1 months to not reached). Patients with SD for ≥ 3 months or PR compared with progressive disease showed both a statistically significant longer median PFS (7.8 months [95% CI, 4.2 to 11.4 months] v 2.2 months [95% CI, 1.5 to 2.8 months], P < .0001) and median OS (18.0 months [95% CI, 10.4 to 25.6 months] v 3.8 months [95% CI, 2.3 to 5.4 months], P < .0001). CONCLUSION Next-generation sequencing diagnostics of advanced GI cancers identified a substantial number of pathogenic or likely pathogenic germline variants and unique individual treatment options. Patients with PR or SD in the course of MTB-recommended treatments seemed to benefit with respect to PFS and OS.
Toward a paradigm shift from deficit-based to proactive speech and language treatment: Randomized pilot trial of the Babble Boot Camp in infants with classic galactosemia
Authors: Peter Beate , Potter Nancy , Davis Jennifer , Donenfeld-Peled Inbal , Finestack Lizbeth , Stoel-Gammon Carol , Lien Kari , Bruce Laurel , Vose Caitlin , Eng Linda , Yokoyama Hanako , Olds Daniel , VanDam Mark 
Published: March 2020

Background: Speech and language therapy is typically initiated reactively after a child shows delays. Infants with classic galactosemia (CG), a metabolic disease with a known high risk for both speech and language disorders, hold the keys towards evaluating whether preventive treatment is effective when the risks are known at birth. We present pilot data from a randomized parallel trial of an innovative proactive speech and language intervention program, the Babble Boot Camp (BBC). Method: Five children with CG, otherwise healthy, participated in the study from approximately 2 to 24 months of age. One of these was randomly selected as control receiving conventional management, which typically starts at age 2-3 years. A pediatric speech-language pathologist met weekly via telepractice with the parents in the treatment cohort. Parents implemented the prespeech, speech, and language stimulation and expansion activities according to the intervention protocol. The control child was still too young for conventional treatment. Primary outcome measures were speech sound production complexity in babble and speech and expressive vocabulary size. Secondary outcome measures were vocalization rates and developmental milestones in communication, motor, and cognition. The trial is ongoing. Results: All four treated children had higher speech sound skills in babble, three had higher speech sound skills in meaningful speech, two had higher expressive vocabularies, three had higher global developmental scores, and two had higher vocalization rates, compared to the control child with CG. Discussion: Given the high risk for speech and language delays in children with CG, finding on-schedule abilities in two or more of the treated children but not the untreated child is unexpected under random conditions. The trends toward beneficial effects of the BBC on speech sound production, expressive language, and communication milestones warrant appropriately powered larger clinical trials with full randomization. Trial registration: ClinicalTrials.gov NCT03838016 (12 th February 2019).
A protocol for an observational cohort study of heat strain and its effect on fetal wellbeing in pregnant farmers in The Gambia
Authors: Bonell Ana , Hirst Jane , Vicedo-Cabrera Ana M. , Haines Andy , Prentice Andrew M. , Maxwell Neil S. 
Published: March 2020

Introduction: Climate change predictions indicate that global temperatures are likely to exceed those seen in the last 200,000 years, rising by around 4°C above pre-industrial levels by 2100 (without effective mitigation of current emission rates). In regions of the world set to experience extreme temperatures, women often work outside in agriculture even during pregnancy. The implications of heat strain in pregnancy on maternal health and pregnancy outcome are not well understood. This protocol describes a study to assess the physiological response of pregnant women to environmental heat stress and the immediate effect this has on fetal wellbeing. Methods and analysis: The study will be performed in West Kiang district, The Gambia; a semi-arid zone in West Africa with daily maximum temperatures ranging from approximately 32 to 40°C. We will recruit 125 pregnant women of all ages who perform agricultural work during their pregnancy. Participants will be followed every two months until delivery. At each study visit fetal growth will be measured by ultrasound scan. During the course of their working day we will take the following measurements: continuous maternal physiological measurements (heart rate, respiratory rate, chest skin temperature and tri-axis accelerometer data); intermittent maternal tympanic core temperature, four point skin temperature, blood pressure; intermittent fetal heart rate and, if eligible, umbilical artery doppler; intermittent environmental measurements of air temperature, humidity, solar radiation and wind speed. Venous blood and urine will be collected at beginning and end of day for biomarkers of heat strain or fetal distress and hydration status.
Using country-level variables to classify countries according to the number of confirmed COVID-19 cases: An unsupervised machine learning approach
Authors: Carrillo-Larco Rodrigo M. , Castillo-Cara Manuel 
Published: March 2020

Background: The COVID-19 pandemic has attracted the attention of researchers and clinicians whom have provided evidence about risk factors and clinical outcomes. Research on the COVID-19 pandemic benefiting from open-access data and machine learning algorithms is still scarce yet can produce relevant and pragmatic information. With country-level pre-COVID-19-pandemic variables, we aimed to cluster countries in groups with shared profiles of the COVID-19 pandemic. Methods: Unsupervised machine learning algorithms (k-means) were used to define data-driven clusters of countries; the algorithm was informed by disease prevalence estimates, metrics of air pollution, socio-economic status and health system coverage. Using the one-way ANOVA test, we compared the clusters in terms of number of confirmed COVID-19 cases, number of deaths, case fatality rate and order in which the country reported the first case. Results: The model to define the clusters was developed with 155 countries. The model with three principal component analysis parameters and five or six clusters showed the best ability to group countries in relevant sets. There was strong evidence that the model with five or six clusters could stratify countries according to the number of confirmed COVID-19 cases (p<0.001). However, the model could not stratify countries in terms of number of deaths or case fatality rate. Conclusions: A simple data-driven approach using available global information before the COVID-19 pandemic, seemed able to classify countries in terms of the number of confirmed COVID-19 cases. The model was not able to stratify countries based on COVID-19 mortality data.
Differentiation Strategies in the Adoption of Environmental Standards: LEED from 2000 to 2014
Authors: Rysman Marc , Simcoe Timothy , Wang Yanfei 
Published: March 2020

We study the role of vertical differentiation in the adoption of LEED (Leadership in Energy & Environmental Design), a multitier environmental building certification system. Our identification strategy relies on the timing of adoption and shows that builders seek to differentiate from each other by choosing a different certification level from previously certified buildings. A common concern in this framework is that mean-reverting behavior could be mistaken for differentiation. We develop a new method for establishing the importance of strategic interactions based on simulating from a model with independent choice and unobserved heterogeneity, and showing that such a model cannot generate the level of interaction that we observe. Finally, we estimate a model that incorporates both differentiation incentives and correlated market-level unobservables and use our estimates from this model to simulate the impact of reducing the number of LEED tiers from four to two. The simulations indicate that environmental investments depend on the location of the threshold between tiers. This paper was accepted by Bruno Cassiman, business strategy.
Avaliação da qualidade de vida em usuários do Centro de Referência em Obesidade (CRO), Rio de Janeiro
Authors: Da Silva Rayane Rebelo Barbosa , Damião Jorginete De Jesus , Bustamante Carlos Gabriel 
Published: March 2020

A obesidade é um grave e crescente problema de saúde pública, e está associada ao aumento de comorbidades e diminuição da qualidade de vida. Este trabalho tem como objetivo avaliar a percepção sobre a qualidade de vida de usuários do Centro de Referência em Obesidade (CRO) da unidade de Acari, Rio de Janeiro, em dois momentos: antes e durante o tratamento para obesidade grave. O protocolo de acompanhamento dos usuários do CRO inclui a avaliação da qualidade de vida, usando o questionário SF-36. Foram selecionados 58 prontuários de usuários com obesidade grau III, de ambos os sexos, que entraram no serviço entre agosto de 2012 e dezembro de 2016, e que possuíam dois questionários SF-36 preenchidos. Descreveram-se a média e o desvio padrão para as variáveis contínuas, e as frequências de variáveis categóricas. Para comparar a evolução dos escores de qualidade de vida, para as variáveis com distribuição paramétrica foi realizado o teste T pareado, e para as variáveis com distribuição não paramétrica, o teste de Wilcoxon. Utilizou-se para a análise dos dados o programa Statistical Package for the Social Science (SPSS), versão 19. Os resultados dos dois questionários foram analisados e comparados. Os oito domínios (aspectos físicos, capacidade funcional, estado geral de saúde, dor, vitalidade, aspectos sociais, aspectos emocionais e saúde mental) apresentaram escores maiores na segunda aplicação do SF-36 (p<0,05), ou seja, houve melhoria da percepção da qualidade de vida em todos os domínios avaliados pelo instrumento, o que parece apontar o impacto positivo do modelo de cuidado multidisciplinar experimentado pelo serviço.
Clinical outcome of posterior-stabilized total knee arthroplasty using an increased flexion gap in patients with preoperative stiffness
Authors: Boettner Friedrich , Sculco Peter , Faschingbauer Martin , Rueckl Kilian , Windhager Reinhard , Kasparek Maximilian F. 
Published: March 2020

AimsTo compare patients undergoing total knee arthroplasty (TKA) with ≤ 80° range of movement (ROM) operated with a 2 mm increase in the flexion gap with matched non-stiff patients with at least 100° of preoperative ROM and balanced flexion and extension gaps.MethodsIn a retrospective cohort study, 98 TKAs (91 patients) with a preoperative ROM of ≤ 80° were examined. Mean follow-up time was 53 months (24 to 112). All TKAs in stiff knees were performed with a 2 mm increased flexion gap. Data were compared to a matched control group of 98 TKAs (86 patients) with a mean follow-up of 43 months (24 to 89). Knees in the control group had a preoperative ROM of at least 100° and balanced flexion and extension gaps. In all stiff and non-stiff knees posterior stabilized (PS) TKAs with patellar resurfacing in combination with adequate soft tissue balancing were used.ResultsOverall mean ROM in stiff knees increased preoperatively from 67° (0° to 80°) to 114° postoperatively (65° to 135°) (p < 0.001). Mean knee flexion improved from 82° (0° to 110°) to 115° (65° to 135°) and mean flexion contracture decreased from 14° (0° to 50°) to 1° (0° to 10°) (p < 0.001). The mean Knee Society Score (KSS) improved from 34 (0 to 71) to 88 (38 to 100) (p < 0.001) and the KSS Functional Score from 43 (0 to 70) to 86 (0 to 100). Seven knees (7%) required manipulations under anaesthesia (MUA) and none of the knees had flexion instability. The mean overall ROM in the control group improved from 117° (100° to 140°) to 123° (100° to 130°) (p < 0.001). Mean knee flexion improved from 119° (100° to 140°) to 123° (100° to 130°) (p < 0.001) and mean flexion contracture decreased from 2° (0° to 15°) to 0° (0° to 5°) (p < 0.001). None of the knees in the control group had flexion instability or required MUA. The mean KSS Knee Score improved from 48 (0 to 80) to 94 (79 to 100) (p < 0.001) and the KSS Functional Score from 52 (5 to 100) to 95 (60 to 100) (p < 0.001). Mean improvement in ROM (p < 0.001) and KSS Knee Score (p = 0.017) were greater in knees with preoperative stiffness compared with the control group, but the KSS Functional Score improvement was comparable (p = 0.885).ConclusionTKA with a 2 mm increased flexion gap provided a significant improvement of ROM in knees with preoperative stiffness. While the improvement in ROM was greater, the absolute postoperative ROM was less than in matched non-stiff knees. PS TKA with patellar resurfacing and a 2 mm increased flexion gap, in combination with adequate soft tissue balancing, provides excellent ROM and knee function when stiffness of the knee had been present preoperatively. Cite this article: Bone Joint J 2020;102-B(4):426–433.
Clinical and radiological outcomes of minimally-invasive surgery for adolescent idiopathic scoliosis at a minimum two years’ follow-up
Authors: de Bodman Charlotte , Ansorge Alexandre , Tabard-Fougère Anne , Amirghasemi Nicolas , Dayer Romain 
Published: March 2020

Aims The direct posterior approach with subperiosteal dissection of the paraspinal muscles from the vertebrae is considered to be the standard approach for the surgical treatment of adolescent idiopathic scoliosis (AIS). We investigated whether or not a minimally-invasive surgery (MIS) technique could offer improved results. Methods Consecutive AIS patients treated with an MIS technique at two tertiary centres from June 2013 to March 2016 were retrospectively included. Preoperative patient deformity characteristics, perioperative parameters, power of deformity correction, and complications were studied. A total of 93 patients were included. The outcome of the first 25 patients and the latter 68 were compared as part of our safety analysis to examine the effect of the learning curve. Results In the first 25 cases, with a mean follow-up of 5.6 years (standard deviation (SD) 0.4), the mean preoperative major Cobb angle was 57.6° (SD 9.8°) and significantly corrected to mean 15.4° (SD 5.6°, 73% curve correction). The mean preoperative T5-T12 was 26.2 (SD 12.8) and significantly increased to mean 32.9 (SD 8.3). Both frontal and sagittal plane correction was conserved two years after surgery. The rate of perioperative complications was 12% and three further complications occurred (three deep delayed infection). In the latter cases, 68 patients were included with a mean follow-up time of three years (SD 0.6). The mean preoperative major Cobb angle was 58.4° (SD 9.2°) and significantly corrected to mean 20.4° (SD 7.3°).The mean preoperative T5-T12 kyphosis was 26.6° (SD 12.8°) and was significantly increased to mean 31.4° (SD 8.3°). Both frontal and sagittal correction was conserved two years after surgery. The perioperative (30 day) complication rate was 1.4%. Two (2.9%) additional complications occurred in two patients. Conclusion MIS for AIS is associated with a significant correction of spine deformity in the frontal and sagittal planes, together with low estimated blood loss and short length of stay. The perioperative complication rate seems to be lower compared with the standard open technique based on the literature data. The longer-term safety of MIS for AIS needs to be documented with a larger cohort and compared with the standard posterior approach. Cite this article: Bone Joint J 2020;102-B(4):506–512.
Environmental factors influence on flowering and fruiting period of selected essential oil plants from Annonaceae
Authors: Lestari Dewi Ayu , Fiqa Abban Putri 
Published: March 2020

Abstract. Lestari DA, Fiqa AP. 2020. Environmental factors influence on flowering and fruiting period of selected essential oil plants from Annonaceae. Biodiversitas 21: 910-921. Many species of Annonaceae family in tropics produce fragrances, due to the active ingredients for essential oils. Since the abundant of flower and fruit production, basic knowledge of flowering and fruiting periods needs to be known. The aim of this study was to determine influence of environmental factors to selected essential oil plants flowering and fruiting period from Annonaceae family, i.e. Artabotrys suaveolens, Cananga odorata, Desmos chinensis, Dasymaschalon borneense, Fissistigma latifolium, and Xylopia malayana. Observations were made throughout the year during dry and rainy season, with each phase carried out scoring qualitatively based on its abundance in plant canopy. Data on environmental factors (temperature, humidity, and rainfall intensity) were obtained from Registration Unit, Purwodadi Botanic Garden (PBG). Data of flowering and fruiting period were analyzed descriptively using Microsoft Excel, while the influence of environmental factors to flowering and fruiting period was analyzed by Biplot with Past 3.0. statistic program. Flowering period occurred in wet months at the end of year (November-December), while fruiting period occurred in long dry month. Initiation and bloom of flowering were influenced by temperature, while fruiting period was largely influenced by humidity and rainfall intensity, except for C. odorata whose fruiting period was influenced by temperature.
Key words: Annonaceae, environmental factors, essential oils, flowering, fruiting
Molecular characterization of lactic acid bacteria producing edible biofilm isolated from kimchi
Authors: FADILLA SAPALINA  , Retnaningrum Endah 
Published: March 2020

Biofilm is a community of microorganisms that interrelated and covered by an extracellular polymer matrix. This biofilm can be produced by Lactic acid bacteria (LAB) which was edible for human and animal. Therefore, it possible to be applied in the food and health industry. One source of LAB is kimchi, as fermented food from Korea and it has good benefits for health. This research aimed to obtain LAB from kimchi that can produce edible biofilms and to identify LAB producing edible biofilms based on the 16S rRNA gene. Isolation of lactic acid bacteria from kimchi cultured in MRS agar medium containing 1% CaCO3, biofilm production test with biofilm assay method and zeolite as a substrate to adherent cells. For amplification of 16S rRNA gene used primer 27F and 1492R. The isolate of KA2, KA5, KB1, and KC4 isolated from kimchi and could produce biofilms with the highest biofilm formation at 48 hours incubation time. Based on molecular identification with 16S rRNA gene sequencing, the four isolates identified as Lactobacillus brevis species.