bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema
Authors: Miglani Manjula , Rain Manjari , Pasha Qadar , Raj V Samuel , Thinlas Tashi , Mohammad Ghulam , Gupta Archana , Pandey Ramendra Pati , Vibhuti Arpana 
Published: September 2020

AbstractHigh-altitude pulmonary edema (HAPE) is a noncardiogenic form of pulmonary edema, which is induced upon exposure to hypobaric hypoxia at high altitude (HA). Hypobaric hypoxia generates reactive oxygen species that may damage telomeres and disturb normal physiological processes. Telomere complex comprises of multiple proteins, of which, tankyrase (TNKS) is actively involved in DNA damage repairs. We hence investigated the association of TNKS and telomeres with HAPE to delineate their potential role at HA. The study was performed in three groups, High-altitude pulmonary edema patients (HAPE-p, n = 200), HAPE-resistant sojourners (HAPE-r, n = 200) and highland permanent healthy residents (HLs, n = 200). Variants of TNKS were genotyped using polymerase chain reaction–restriction fragment length polymorphism. Plasma TNKS level was estimated using enzyme-linked immunosorbent assay, expression of TNKS and relative telomere length were assessed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and telomerase activity was assessed by the telomere repeat amplification protocol assay. TNKS poly-ADP ribosylates the telomere-repeat factor (TRF), which is a negative regulator of telomere length. Consequently, TRF expression was also measured by RT-qPCR. The TNKS heterozygotes rs7015700GA were prevalent in HLs compared to the HAPE-p and HAPE-r. The plasma TNKS was significantly decreased in HAPE-p than HAPE-r (P = 0.006). TNKS was upregulated 9.27 folds in HAPE-p (P = 1.01E-06) and downregulated in HLs by 3.3 folds (P = 0.02). The telomere length was shorter in HAPE-p compared to HAPE-r (P = 0.03) and HLs (P = 4.25E-4). The telomerase activity was significantly higher in HAPE-p compared to both HAPE-r (P = 0.01) and HLs (P = 0.001). HAPE-p had the lowest TNKS levels (0.186 ± 0.031 ng/μl) and the highest telomerase activity (0.0268 amoles/μl). The findings of the study indicate the association of TNKS and telomeres with HA adaptation/maladaptation.
Large Diversity in Nitrogen- and Sulfur-Containing Compatible Solute Profiles in Polar and Temperate Diatoms
Authors: Dawson H M , Heal K R , Torstensson A , Carlson L T , Ingalls A E , Young J N 
Published: September 2020

Synopsis
Intense bottom-ice algal blooms, often dominated by diatoms, are an important source of food for grazers, organic matter for export during sea ice melt, and dissolved organic carbon. Sea-ice diatoms have a number of adaptations, including accumulation of compatible solutes, that allows them to inhabit this highly variable environment characterized by extremes in temperature, salinity, and light. In addition to protecting them from extreme conditions, these compounds present a labile, nutrient-rich source of organic matter, and include precursors to climate active compounds (e.g., dimethyl sulfide [DMS]), which are likely regulated with environmental change. Here, intracellular concentrations of 45 metabolites were quantified in three sea-ice diatom species and were compared to two temperate diatom species, with a focus on compatible solutes and free amino acid pools. There was a large diversity of metabolite concentrations between diatoms with no clear pattern identifiable for sea-ice species. Concentrations of some compatible solutes (isethionic acid, homarine) approached 1 M in the sea-ice diatoms, Fragilariopsis cylindrus and Navicula cf. perminuta, but not in the larger sea-ice diatom, Nitzschia lecointei or in the temperate diatom species. The differential use of compatible solutes in sea-ice diatoms suggests different adaptive strategies and highlights which small organic compounds may be important in polar biogeochemical cycles.
The 40 health systems, COVID-19 (40HS, C-19) study
Authors: Braithwaite Jeffrey , Tran Yvonne , Ellis Louise A , Westbrook Johanna 
Published: September 2020

Abstract

Background
The health, social and economic consequences of the severe acute respiratory syndrome coronavirus (SARS-CoV-2, henceforth COVID-19) pandemic have loomed large as every national government made decisions about how to respond. The 40 Health Systems, COVID-19 (40HS, C-19) study aimed to investigate relationships between governments’ capacity to respond (CTR), their response stringency, scope of COVID-19 testing and COVID-19 outcomes.

Methods
Data over March and April 2020 were extracted for 40 national health systems on prepandemic government CTR (Global Competitiveness Index), stringency measures (Oxford COVID-19 Government Response Tracker Stringency Index), approach to COVID-19 testing and COVID-19 cases and deaths (Our-World-in-Data). Multidimensional scaling (MDS) and cluster analysis were applied to examine latent dimensions and visualize country similarities and dissimilarities. Outcomes were tested using multivariate and one-way analyses of variances and Kruskal–Wallis H tests.

Results
The MDS model found three dimensions explaining 91% of the variance and cluster analysis identified five national groupings. There was no association between national governments’ prepandemic CTR and the adoption of early stringent public health measures or approach to COVID-19 testing. Two national clusters applied early stringency measures and reported significantly lower cumulative deaths. The best performing national cluster (comprising Australia, South Korea, Iceland and Taiwan) adopted relatively early stringency measures but broader testing earlier than others, which was associated with a change in disease trajectory and the lowest COVID-19 death rates. Two clusters (one with high CTR and one low) both adopted late stringency measures and narrow testing and performed least well in COVID-19 outcomes.

Conclusion
Early stringency measures and intrinsic national capacities to deal with a pandemic are insufficient. Extended stringency measures, important in the short term, are not economically sustainable. Broad-based testing is key to managing COVID-19.
Antileishmanial effect of the natural immunomodulator genipin through suppression of host negative regulatory protein UCP2
Authors: Gupta Anand Kumar , Roy Shalini , Das Pijush K 
Published: September 2020

AbstractObjectivesTo evaluate the antileishmanial efficacy of genipin, which specifically inhibits uncoupling protein 2 (UCP2) that is induced in leishmaniasis to neutralize reactive oxygen species (ROS).MethodsThe effect of genipin was assessed against intracellular parasites in cultured macrophages and in suppressing spleen and liver parasite burdens in a BALB/c mouse model of visceral leishmaniasis by microscopic evaluation of intracellular amastigotes stained with Giemsa. ROS and mitochondrial membrane potential were measured by H2DCFDA- and JC-1-based fluorometric analysis. ELISA was performed for various Th1 and Th2 cytokines in both in vitro and in vivo infected conditions to evaluate the type of immunological responses. The role of UCP2 was assessed by lipofectamine-mediated transfection and overexpression in macrophages and short hairpin RNA-mediated knockdown of UCP2 in infected animals.ResultsGenipin reduced the infection-induced UCP2 levels in macrophages, with optimum effect at 100 μM. Genipin reversed parasite-induced ROS suppression and mitochondrial membrane potential disruption. It has no inhibitory effect on promastigote or axenic amastigote forms, but markedly suppressed amastigote multiplication within macrophages, which was reversed by the ROS scavenger N-acetyl cysteine. Genipin administration (30 mg/kg/day) in infected mice showed significant suppression of liver and spleen parasite burdens with an enhanced host-favourable cytokine balance in a ROS–p38 mitogen-activated protein kinase-dependent manner. Co-treatment with genipin plus a sublethal dose of sodium antimony gluconate (SAG50) showed almost a curative reduction in spleen and liver parasite burden.ConclusionsThese results suggest the effectiveness of genipin as a synergistic agent for the front-line antileishmanial drug SAG in circumventing the resistance and toxicity problems associated with its high curative dose.
One Brand, Many Trajectories: Narrative Navigation in Transmedia
Authors: Feiereisen Stephanie , Rasolofoarison Dina , Russell Cristel Antonia , Schau Hope Jensen 
Published: September 2020

AbstractIn an era of unprecedented consumer access to media and the tools to control narrative delivery, speed, and exposure to transmedia content, there is no longer the illusion of a cohesive narrative managed by a recognized singular author or unified authorial voice. Instead, consumers carve their own trajectories through brand narratives. Our multimethod inquiry of television series viewing, based on a combination of interviews, diaries, video recordings followed by member-check interviews and online forum analyses, identifies two key forces that guide narrative navigation: how consumers manage a text’s gravitational pull and its permeability to transmedia content. We find that consumers shape their own trajectories by adopting and/or moving between nine documented narrative positions. This more nuanced understanding of narrative consumption in a transmedia environment offers new insights for the study of narrative brand spaces and brand storytelling.
Enlightenment architectures: the reconstruction of Sir Hans Sloane’s cabinets of ‘Miscellanies’
Authors: Sloan Kim , Nyhan Julianne 
Published: September 2020

Abstract
Focusing on Sir Hans Sloane’s catalogue of ‘Miscellanies’, now in the British Museum, this paper asks firstly how Sloane described objects and secondly whether the original contents of the cabinets can be reconstructed from his catalogue. Drawing on a sustained, digitally augmented analysis – the first of its kind – of Sloane’s catalogues, we respond to these questions and offer an initial analysis of the contents of the cabinets that held the miscellaneous objects at Sloane’s manor house in Chelsea. Knowledge of how and why Sloane catalogued this part of his collection has hitherto remained underdeveloped. We argue that his focus on preservation and documentation in his cataloguing did not preclude a research role, but rather was founded on immersive participation. Our work was undertaken as part of a Leverhulme Trust funded research project, Enlightenment Architectures: Sir Hans Sloane’s Catalogues of his Collections (2016–19), a collaboration between the British Museum and University College London.
Modeling the Sensitivity of Blacklegged Ticks (Ixodes scapularis) to Temperature and Land Cover in the Northeastern United States
Authors: Winter Jonathan M , Partridge Trevor F , Wallace Dorothy , Chipman Jonathan W , Ayres Matthew P , Osterberg Erich C , Dekker Eliza R 
Published: September 2020

AbstractThe prevalence of Lyme disease and other tick-borne diseases is dramatically increasing across the United States. While the rapid rise in Lyme disease is clear, the causes of it are not. Modeling Ixodes scapularis Say (Acari: Ixodidae), the primary Lyme disease vector in the eastern United States, presents an opportunity to disentangle the drivers of increasing Lyme disease, including climate, land cover, and host populations. We improved upon a recently developed compartment model of ordinary differential equations that simulates I. scapularis growth, abundance, and infection with Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) by adding land cover effects on host populations, refining the representation of growth stages, and evaluating output against observed data. We then applied this model to analyze the sensitivity of simulated I. scapularis dynamics across temperature and land cover in the northeastern United States. Specifically, we ran an ensemble of 232 simulations with temperature from Hanover, New Hampshire and Storrs, Connecticut, and land cover from Hanover and Cardigan in New Hampshire, and Windsor and Danielson in Connecticut. Consistent with observations, simulations of I. scapularis abundance are sensitive to temperature, with the warmer Storrs climate significantly increasing the number of questing I. scapularis at all growth stages. While there is some variation in modeled populations of I. scapularis infected with B. burgdorferi among land cover distributions, our analysis of I. scapularis response to land cover is limited by a lack of observations describing host populations, the proportion of hosts competent to serve as B. burgdorferi reservoirs, and I. scapularis abundance.
Ferroptosis in plants: triggers, proposed mechanisms, and the role of iron in modulating cell death
Authors: Distéfano Ayelén Mariana , López Gabriel Alejandro , Setzes Nicolás , Marchetti Fernanda , Cainzos Maximiliano , Cascallares Milagros , Zabaleta Eduardo , Pagnussat Gabriela Carolina 
Published: September 2020

AbstractRegulated cell death plays key roles during essential processes throughout the plant life cycle. It takes part in specific developmental programs and maintains homeostasis of the organism in response to unfavorable environments. Ferroptosis is a recently discovered iron-dependent cell death pathway characterized by the accumulation of lipid reactive oxygen species. In plants, ferroptosis shares all the main hallmarks described in other systems. Those specific features include biochemical and morphological signatures that seem to be conserved among species. However, plant cells have specific metabolic pathways and a high degree of metabolic compartmentalization. Together with their particular morphology, these features add more complexity to the plant ferroptosis pathway. In this review, we summarize the most recent advances in elucidating the roles of ferroptosis in plants, focusing on specific triggers, the main players, and underlying pathways.
Multi-dimensional Interpretations of Presburger Arithmetic in Itself
Authors: Pakhomov Fedor , Zapryagaev Alexander 
Published: September 2020

Abstract
Presburger arithmetic is the true theory of natural numbers with addition. We study interpretations of Presburger arithmetic in itself. The main result of this paper is that all self-interpretations are definably isomorphic to the trivial one. Here we consider interpretations that might be multi-dimensional. We note that this resolves a conjecture by Visser (1998, An overview of interpretability logic. Advances in Modal Logic, pp. 307–359). In order to prove the result, we show that all linear orderings that are interpretable in $({\mathbb{N}},+)$ are scattered orderings with the finite Hausdorff rank and that the ranks are bounded in the terms of the dimensions of the respective interpretations.
The Galactic cosmic ray intensity at the evolving Earth and young exoplanets
Authors: Rodgers-Lee D , Vidotto A A , Taylor A M , Rimmer P B , Downes T P 
Published: September 2020

ABSTRACT
Cosmic rays may have contributed to the start of life on the Earth. Here, we investigate the evolution of the Galactic cosmic ray spectrum at the Earth from ages t = 0.6−6.0 Gyr. We use a 1D cosmic ray transport model and a 1.5D stellar wind model to derive the evolving wind properties of a solar-type star. At $t=1\,$ Gyr, approximately when life is thought to have begun on the Earth, we find that the intensity of ∼GeV Galactic cosmic rays would have been ∼10 times smaller than the present-day value. At lower kinetic energies, Galactic cosmic ray modulation would have been even more severe. More generally, we find that the differential intensity of low-energy Galactic cosmic rays decreases at younger ages and is well described by a broken power law in solar rotation rate. We provide an analytic formula of our Galactic cosmic ray spectra at the Earth’s orbit for different ages. Our model is also applicable to other solar-type stars with exoplanets orbiting at different radii. Specifically, we use our Galactic cosmic ray spectrum at 20 au for $t=600\,$ Myr to estimate the penetration of cosmic rays in the atmosphere of HR 2562b, a directly imaged exoplanet orbiting a young solar-type star. We find that the majority of particles &lt;0.1 GeV are attenuated at pressures ≳10−5 bar and thus do not reach altitudes below ∼100 km. Observationally constraining the Galactic cosmic ray spectrum in the atmosphere of a warm Jupiter would in turn help constrain the flux of cosmic rays reaching young Earth-like exoplanets.
Particle acceleration by interstellar plasma shock waves in non-uniform background magnetic field
Authors: Rashed-Mohassel P , Ghorbanalilu M 
Published: September 2020

ABSTRACTParticle acceleration by plasma shock waves is investigated for a magnetized plasma cloud propagating in a non-uniform background magnetic field by means of analytical and numerical calculations. The mechanism studied here is mainly, magnetic trapping acceleration (MTA) which is previously investigated for a cloud moving through the uniform interstellar magnetic field (IMF). In this work, the acceleration is studied for a cloud moving in an antiparallel background field with spatial variations along the direction of motion. For negative variation, the cloud moves towards an antiparallel magnetic field with an increasing intensity, the trapped particle moves to locations with higher convective electric field and therefore gains more energy over time. For positive variation, the background field decreases to zero and changes into a parallel field with an increasing intensity. It is concluded that, when the background field vanishes, the MTA mechanism ceases and the particle escapes into the space. This leads to a bouncing acceleration which further increases energy of the gyrating particle. The two processes are followed by a shock drift acceleration, where due to the background magnetic field gradient, the particle drifts along the electric field and gains energy. Although for positive variation, three different mechanisms are involved, energy gain is less than in the case of a uniform background field.
Proton core behaviour inside magnetic field switchbacks
Authors: Woolley Thomas , Matteini Lorenzo , Horbury Timothy S , Bale Stuart D , Woodham Lloyd D , Laker Ronan , Alterman Benjamin L , Bonnell John W , Case Anthony W , Kasper Justin C , Klein Kristopher G , Martinović Mihailo M , Stevens Michael 
Published: September 2020

ABSTRACT
During Parker Solar Probe’s first two orbits, there are widespread observations of rapid magnetic field reversals known as switchbacks. These switchbacks are extensively found in the near-Sun solar wind, appear to occur in patches, and have possible links to various phenomena such as magnetic reconnection near the solar surface. As switchbacks are associated with faster plasma flows, we questioned whether they are hotter than the background plasma and whether the microphysics inside a switchback is different to its surroundings. We have studied the reduced distribution functions from the Solar Probe Cup instrument and considered time periods with markedly large angular deflections to compare parallel temperatures inside and outside switchbacks. We have shown that the reduced distribution functions inside switchbacks are consistent with a rigid velocity space rotation of the background plasma. As such, we conclude that the proton core parallel temperature is very similar inside and outside of switchbacks, implying that a temperature–velocity (T–V) relationship does not hold for the proton core parallel temperature inside magnetic field switchbacks. We further conclude that switchbacks are consistent with Alfvénic pulses travelling along open magnetic field lines. The origin of these pulses, however, remains unknown. We also found that there is no obvious link between radial Poynting flux and kinetic energy enhancements suggesting that the radial Poynting flux is not important for the dynamics of switchbacks.
Large-scale simulations of H and He reionization and heating driven by stars and more energetic sources
Authors: Eide Marius B , Ciardi Benedetta , Graziani Luca , Busch Philipp , Feng Yu , Di Matteo Tiziana 
Published: September 2020

ABSTRACT
We present simulations of cosmic reionization and reheating from z = 18 to z = 5, investigating the role of stars (emitting soft UV-photons), nuclear black holes (BHs, with power-law spectra), X-ray binaries (XRBs, with hard X-ray dominated spectra), and the supernova-associated thermal bremsstrahlung of the diffuse interstellar medium (ISM, with soft X-ray spectra). We post-process the hydrodynamical simulation MassiveBlack-II (MBII) with multifrequency ionizing radiative transfer. The source properties are directly derived from the physical environment of MBII, and our only real free parameter is the ionizing escape fraction fesc. We find that, among the models explored here, the one with an escape fraction that decreases with decreasing redshift yields results most in line with observations, such as of the neutral hydrogen fraction and the Thomson scattering optical depth. Stars are the main driver of hydrogen reionization and consequently of the thermal history of the intergalactic medium (IGM). We obtain 〈xH ii〉 = 0.99998 at z = 6 for all source types, with volume-averaged temperatures $\langle \, T \rangle \sim 20\,000$ K. BHs are rare and negligible to hydrogen reionization, but conversely they are the only sources that can fully ionize helium, increasing local temperatures by ∼104 K. The thermal and ionization state of the neutral and lowly ionized hydrogen differs significantly with different source combinations, with ISM and (to a lesser extent) XRBs, playing a significant role and, as a consequence, determining the transition from absorption to emission of the 21-cm signal from neutral hydrogen.
Formation and evolution of the local interstellar environment: combined constraints from nucleosynthetic and X-ray data
Authors: Fujimoto Yusuke , Krumholz Mark R , Inutsuka Shu-ichiro , Boss Alan P , Nittler Larry R 
Published: September 2020

ABSTRACT
Several observations suggest that the Solar system has been located in a region affected by massive stellar feedback for at least a few Myr; these include detection of live 60Fe in deep-sea archives and Antarctic snow, the broad angular distribution of 26Al around the Galactic plane seen in all-sky γ-ray maps, and the all-sky soft X-ray background. However, our position inside the Galactic disc makes it difficult to fully characterize this environment, and our limited time baseline provides no information about its formation history or relation to large-scale galactic dynamics. We explore these questions by using an N-body + hydrodynamics simulation of a Milky-Way-like galaxy to identify stars on Sun-like orbits whose environments would produce conditions consistent with those we observe. We find that such stars are uncommon but not exceptionally rare. These stars are found predominantly near the edges of spiral arms, and lie inside kpc-scale bubbles that are created by multiple generations of star formation in the arm. We investigate the stars’ trajectories and find that the duration of the stay in the bubble ranges from 20 to 90 Myr. The duration is governed by the crossing time of stars across the spiral arm. This is generally shorter than the bubble lifetime, which is ∼100 Myr as a result of the continuous gas supply provided by the arm environment.