bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of early career social capital on long-term income development in Finland
Authors: Oinas Tomi , Ruuskanen Petri , Hakala Mari , Anttila Timo 
Published: June 2020

PurposeIn this study, the authors examine whether social capital embedded in individuals' social networks is connected to employees' long-term income development in Finland.Design/methodology/approachAnalyses are based on 25–35-year-old employees from the Finnish Living Conditions Survey of 1994 combined with register data on earned incomes from 1995 to 2016. The authors used questions addressing the frequency of meeting parents or siblings, spending free time with co-workers and participation in associational, civic or other societal activities as measures of the extent of network capital. Ordered logistic model was used to examine whether the size and composition of social networks differ by gender and socio-economic status. Linear growth curve models were employed to estimate the effect of social capital on long-term income development.FindingsResults indicate minor differences in network composition according to gender, but large differences between socio-economic groups. The authors found that income development was faster for those who participated in civic activities occasionally or who met their relatives or co-workers on a monthly basis, that is, for the “middle group”.Research limitations/implicationsResults are generalizable only to Finnish or Nordic welfare state context. The authors’ measures of social capital come from cross-sectional survey. Thus, the authors are not able to address the stability or accumulation of social capital during life course. This restriction will probably cause the authors’ analysis to underestimate the true effect of social capital on earned incomes.Practical implicationsModerate-level investments to network capital seem to be the most beneficial with regard to the long-term income development.Social implicationsThe study results give support to the idea that social capital can be transformed into economic capital. The results also imply that in economic terms it is important to balance diverse forms of social capital. At the policy level, a special emphasis should be directed to employees with low-socio-economic position. These people are especially vulnerable as their low level of income is combined with network composition that hinders their further income development.Originality/valueThe combined survey and register data give unique insight on how the social capital embedded in individuals' social networks is connected with long-term income development.
The moderating effect of virtual integration on intergenerational governance and relationship performance in international customer–supplier relationships
Authors: Jean Ruey-Jer Bryan , Kim Daekwan , Lien Yung-Chih , Ro Sangbum 
Published: June 2020

PurposeWith the growing trend of digital technology in global supply chains, how to manage global supply chain relationships under digital transformation becomes a critical issue. However, academic research in this area is sparse. This study develops and tests a theoretical framework of the moderating effect of virtual integration on interorganziational governance in international customer supplier relationships.Design/methodology/approachWe chose to examine the specific cross-border relationships between Taiwanese suppliers and their international OEMs because Taiwanese suppliers tend to be smaller than their international OEM customers, and thus their relationships usually show power asymmetry. Furthermore, the Taiwanese electronics industry offers a valuable empirical context because its industry members have served as pioneers in information technology development, have championed cross-border relationships with US and European industry leaders and are actively participating in the world economyFindingsOur empirical findings indicate that virtual integration will strengthen the effect contractual governance on relationship performance. However, the moderating effect of virtual integration on relational governance is not significant. The paper discusses the theoretical and managerial implications in the end.Originality/valueThis study contributes to interorganizational governance literature in international contexts. Previous work on international relationship management has focused much on MNE buyers' perspectives and paid little attention to the suppliers' perspectives. This study extends this stream of research by empirically examining how suppliers can govern their MNEs' customers via different governance mechanisms. The findings extend literature on virtual integration and show that virtual integration can complement detailed contract and safeguard opportunism, which in turn, enhance relationship performance in international customer–supplier relationships.
Increasing or decreasing reading trend: an overview of the current status of the public libraries in Khyber Pakhtunkhwa, Pakistan
Authors: Rafi Muhammad , Ahmad Khurshid , Jian Ming Zheng 
Published: June 2020

PurposeAs the human race moved from the Paleolithic to the current phases of the Neolithic period, the learning process developed from inscriptions on stones to clay tablets, from papyrus to papers and, ultimately, to digital technology. From ancient times to the present, public libraries have become open universities that are more democratic in the provision of educational and information services and the preservation of cultural heritage, regardless of gender and belief. This study attempts to understand reading trends and the use of citizens’ resources in public libraries in the age of technology as an open university.Design/methodology/approachThe data for this study on regular visitors, permanent library members, and information on the library inventory was collected from each public library administration through personal visits and interviews. In addition, data on regional population and literacy rates were collected from the Government of the Khyber Pakhtunkhwa Provincial Bureau of Statistics. The authors used descriptive statistics to analyze data for comparative studies.FindingsThe results show that daily visitors, regular library members and their use of library resources are decreasing compared to the literacy rate in each district. It was also concluded that, due to a lack of education and training in the area of information and digital literacy, the accessed database resources are not used properly. Moreover, each densely populated district relies on a single public library to meet general education and information needs.Practical implicationsThe results of this study will help the government expand the network of public libraries at the union council level with competent working staff to increase general motivation to improve reading and resource usage trends. Given the current literacy and population growth in each district, the law on the public library can also be amended and implemented to support the existing library system better and create more libraries in the public interest.Originality/valueThis study was conducted for the first time to determine the current state of public libraries in Khyber Pakhtunkhwa and to help public library authorities improve their existing public library service status based on the results.
Environmental disclosure quality and risk: the moderating effect of corporate governance
Authors: Rezaee Zabihollah , Alipour Mohammad , Faraji Omid , Ghanbari Mehrdad , Jamshidinavid Babak 
Published: June 2020

PurposeThe purpose of this article is to investigate the relationship between environmental disclosure quality (EDQ) and risk and to further examine whether corporate governance (CG) practices moderate this relationship.Design/methodology/approachThis study uses a set of unique, hand collected data (from 2011 to 2016) to measure EDQ for a sample of 762 firm-years Iranian listed companies. Ordinary least squares regression analysis is performed in testing hypotheses after controlling for a variety of firm, industry and year effects. Moreover, several analyses are performed to establish the robustness of the findings.FindingsThe results indicate a negative association between EDQ and firm risk. While board independence moderates this relationship, other CG practices such as CEO duality and board size do not show any effects on the relationship between EDQ and risk. The results remain robust after performing sensitivity tests and under various specifications, including the fixed-effects panel data and Heckman two-stage regressions.Research limitations/implicationsResults are from a sample of firms from one country.Practical implicationsThe results have implications for policymakers, legislators and corporate executives, as environmental initiatives are gaining more attention worldwide.Social implicationsSustainability initiatives in the areas of environmental and social performance and disclosure are gaining global attention. This study addresses the link between firm risk and EDQ.Originality/valueThis study contributes to the literature by shedding light on the relationship between corporate risk-taking and EDQ in the context of a developing economy.
Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo
Authors: Chéret Jérémy , Gherardini Jennifer , Soeberdt Michael , Hundt Jennifer E. , Abels Christoph , Bertolini Marta , Paus Ralf 
Published: June 2020

AbstractKappa‐opioid receptor (KOR) activation reportedly elicits anti‐inflammatory responses and can downregulate neuropeptide release from sensory nerve fibers. While this renders KOR agonists (KORAs) potentially interesting therapeutics in skin diseases associated with neurogenic inflammation, it remains poorly understood how KOR agonists impact on human skin and dermal mast cells (MCs) ex vivo, in the absence of functional innervation. The KORA 5a was administrated to the culture medium (200 nmol/L and 1 µmol/L) in human skin organ culture, thus mimicking a “systemic” mode of application. We show that KORA significantly increased epidermal thickness and upregulated the number and proliferation of epidermal keratinocytes. Unexpectedly, it also stimulated epidermal keratinocyte apoptosis in situ, compared with vehicle. Moreover, KORA significantly decreased the number of c‐Kit‐positive MCs, but did not significantly alter the number or degranulation of mature (tryptase‐ or toluidine blue‐positive) MCs. These pilot observations render the tested KORA (5a) an interesting candidate for the management of inflammatory dermatoses in which MC‐dependent neurogenic skin inflammation plays an important role (e.g. atopic dermatitis, psoriasis).
Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population
Authors: Zhao Tianyun , Ma Chi , Wang Wei , Zhao Bin , Xie Baopin , Liu Jibin 
Published: June 2020

AbstractAimThe prevalence of hip and knee osteoarthritis (OA) varies by ethnicity, suggesting genetic heterogeneity in populations and predilection sites. Given the unknown mechanism of IL17F gene in the etiology of OA, it is necessary to examine the potential shared susceptibility of IL17F gene between knee OA and hip OA (HOA). This study aimed to evaluate the association of the IL17F gene and susceptibility to HOA in a Han Chinese population.MethodsA total of 2650 study subjects, comprising 796 HOA patients and 1854 controls, were recruited into the present study. Seven tag single nucleotide polymorphisms (SNPs) were selected for genotyping. Single marker‐based genetic association analyses were conducted at both the genotypic and allelic levels. χ2 statistics were calculated for statistical testing, and odds ratios were obtained to estimate the effects of genotypes and alleles for each SNP.ResultsThe SNP rs763780 was identified to be significantly associated with the risk of HOA at both genotypic (χ2 = 12.45, P = .002) and allelic levels (χ2 = 11.83, P = .0006). A linkage disequilibrium (LD) block comprised of 3 SNPs (rs12201582‐rs12203736‐rs722323) was also significantly associated with the risk of HOA. In addition, rs2294835 was identified to be associated with HOA severity (χ2 = 12.10, P = .02).ConclusionOur results showed that IL17F gene contributed to the risk of HOA in a Han Chinese population, which would help to elucidate the pathogenesis of OA and facilitate the development of novel medicines and treatments for OA.
Diet‐MEF2 interactions shape lipid droplet diversification in muscle to influence Drosophila lifespan
Authors: Zhao Xiao , Li Xiaotong , Shi Xiangyu , Karpac Jason 
Published: June 2020

AbstractThe number, size, and composition of lipid droplets can be influenced by dietary changes that shift energy substrate availability. This diversification of lipid droplets can promote metabolic flexibility and shape cellular stress responses in unique tissues with distinctive metabolic roles. Using Drosophila, we uncovered a role for myocyte enhancer factor 2 (MEF2) in modulating diet‐dependent lipid droplet diversification within adult striated muscle, impacting mortality rates. Muscle‐specific attenuation of MEF2, whose chronic activation maintains glucose and mitochondrial homeostasis, leads to the accumulation of large, cholesterol ester‐enriched intramuscular lipid droplets in response to high calorie, carbohydrate‐sufficient diets. The diet‐dependent accumulation of these lipid droplets also correlates with both enhanced stress protection in muscle and increases in organismal lifespan. Furthermore, MEF2 attenuation releases an antagonistic regulation of cell cycle gene expression programs, and up‐regulation of Cyclin E is required for diet‐ and MEF2‐dependent diversification of intramuscular lipid droplets. The integration of MEF2‐regulated gene expression networks with dietary responses thus plays a critical role in shaping muscle metabolism and function, further influencing organismal lifespan. Together, these results highlight a potential protective role for intramuscular lipid droplets during dietary adaptation.
Practical wisdom: A virtue for leaders. Bringing together Aquinas and Authentic Leadership
Authors: Ferrero Ignacio , Rocchi Marta , Pellegrini Massimiliano Matteo , Reichert Elizabeth 
Published: June 2020

AbstractThis article analyzes in detail the virtue of practical wisdom as described by Thomas Aquinas, and on this basis it develops a comprehensive framework to enrich Authentic Leadership theory, establishing the virtue of practical wisdom as foundational for the authentic leader’s behavior and character development, and highlighting shortfalls that may stem from vices opposed to it. The goal of the article is two‐fold: First, it seeks to fill a void on the role of virtues–and in particular practical wisdom–in leadership studies; second, it aims to show how cultivating the virtue of practical wisdom as described by Aquinas promotes the development of exactly those traits that are characteristic of an authentic leader, offering a set of propositions delineating these correlations.
The psychosocial impact of facial palsy: A systematic review
Authors: Hotton Matthew , Huggons Esme , Hamlet Claire , Shore Danielle , Johnson David , Norris Jonathan H. , Kilcoyne Sarah , Dalton Louise 
Published: June 2020

PurposeFacial palsy is a condition which can lead to significant changes in facial function and appearance. People with facial palsy often report psychosocial difficulties, including withdrawal from social activities, anxiety, negative body image, and low mood. This paper aimed to review all published research investigating the psychosocial impact of facial palsy on adults.MethodsA systematic search of MEDLINE, CINAHL, EMBASE, PsycINFO, and AMED databases was performed. The quality of included studies was assessed, and data were extracted with regard to characteristics of participants; study methodology and design; outcome measures used; and psychosocial outcomes.ResultsTwenty‐seven studies met inclusion criteria. A high proportion of people with facial palsy reported clinically significant levels of anxiety and depression, with greater difficulties typically reported by females, compared to males. Other difficulties consistently reported include low quality of life, poor social function, and high levels of appearance‐related distress. Objective severity of facial palsy was consistently shown to not be associated with anxiety or depression, with psychological factors instead likely mediating the relationship between the severity of facial palsy and psychosocial well‐being.ConclusionsIrrespective of objective symptom severity, facial palsy has the potential to have a significant impact on psychosocial well‐being and quality of life. The various methodological limitations of the included studies are discussed, along with clinical implications, including the need for greater access to psychological screening and interventions for people with facial palsy.
A systematic review on mutation markers for bladder cancer diagnosis in urine
Authors: Hentschel Anouk E. , van der Toom Emma E. , Vis André N. , Ket Johannes C.F. , Bosschieter Judith , Heymans Martijn W. , van Moorselaar R. Jeroen A. , Steenbergen Renske D.M. , Nieuwenhuijzen Jakko A. 
Published: June 2020

ObjectivesTo systematically summarise the available evidence on urinary bladder cancer (BC) mutation markers. Gene mutations are expected to provide novel biomarkers for urinary BC diagnosis. To date, evidence on urinary BC mutation markers has not proven sufficient to be adopted by clinical guidelines. In the present systematic review, diagnostic accuracy of urinary mutation analysis is separately assessed for primary BC diagnosis (BC detection) and for follow‐up of BC patients (BC surveillance).MethodsA literature search (PubMed, Embase.com and Wiley/Cochrane Library) and systematic review was performed up to 31 October 2019. As studies were too heterogeneous, no quantitative analysis could be performed.ResultsIn total, 25 studies were summarised by qualitative analysis. For BC detection, diagnostic accuracy differed considerably for single mutation markers (sensitivity 1–85%, specificity 84–100%), and for marker panels (sensitivity 50–94%, specificity 43–97%). Similarly, for BC surveillance, diagnostic accuracy was highly variable for single mutation markers (sensitivity 0–85%, specificity 66–100%), and for marker panels (sensitivity 51–84%, specificity 66–96%).ConclusionUrinary mutation analysis showed to be a promising diagnostic tool for non‐invasive BC diagnosis. Nonetheless, we observed substantial differences in diagnostic accuracy of urinary BC mutation markers among publications. To translate the data summarised in the present review to future clinical practice, heterogeneity in research design, BC population, mutation analysis technique and urinary DNA should be considered. Eventual clinical implementation of urinary BC mutation markers can only be achieved by collecting more and stronger evidence. Combining different molecular assays might overcome current shortcomings of urinary mutation analysis.
Generation of a novel CD30+ B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis
Authors: Higashioka K , Kikushige Y , Ayano M , Kimoto Y , Mitoma H , Kikukawa M , Akahoshi M , Arinobu Y , Horiuchi T , Akashi K , Niiro H 
Published: June 2020

Summary
Systemic sclerosis (SSc) is a T helper type 2 (Th2)-associated autoimmune disease characterized by vasculopathy and fibrosis. Efficacy of B cell depletion therapy underscores antibody-independent functions of B cells in SSc. A recent study showed that the Th2 cytokine interleukin (IL)-4 induces granulocyte–macrophage colony-stimulating factor (GM-CSF)-producing effector B cells (GM-Beffs) in humans. In this study, we sought to elucidate the generation mechanism of GM-Beffs and also determine a role of this subset in SSc. Among Th-associated cytokines, IL-4 most significantly facilitated the generation of GM-Beffs within memory B cells in healthy controls (HCs). In addition, the profibrotic cytokine transforming growth factor (TGF)-β further potentiated IL-4- and IL-13-induced GM-Beffs. Of note, tofacitinib, a Janus kinase (JAK) inhibitor, inhibited the expression of GM-CSF mRNA and protein in memory B cells induced by IL-4, but not by TGF-β. GM-Beffs were enriched within CD20+CD30+CD38−/low cells, a distinct population from plasmablasts, suggesting that GM-Beffs exert antibody-independent functions. GM-Beffs were also enriched in a CD30+ fraction of freshly isolated B cells. GM-Beffs generated under Th2 conditions facilitated the differentiation from CD14+ monocytes to DC-SIGN+CD1a+CD14−CD86+ cells, which significantly promoted the proliferation of naive T cells. CD30+ GM-Beffs were more pronounced in patients with SSc than in HCs. A subpopulation of SSc patients with the diffuse type and concomitant interstitial lung disease exhibited high numbers of GM-Beffs. Together, these findings suggest that human GM-Beffs are enriched in a CD30+ B cell subset and play a role in the pathogenesis of SSc.
Lee Silverman Voice Treatment for dysarthria in patients with Parkinson’s disease: a systematic review and meta‐analysis
Authors: Yuan F. , Guo X. , Wei X. , Xie F. , Zheng J. , Huang Y. , Huang Z. , Chang Z. , Li H. , Guo Y. , Chen J. , Guo J. , Tang B. , Deng B. , Wang Q. 
Published: June 2020

Approximately 89% of patients with Parkinson’s disease (PD) suffer from dysarthria. Lee Silverman Voice Treatment (LSVT), a behavioral therapy, aims to improve speech and voice functions. The objective was to assess the effectiveness of LSVT compared with other/no speech interventions for dysarthria in patients with PD. Electronic databases, including PubMed, Embase and the Cochrane Library, were searched. The publication date of all included studies was before 6 March 2020. Only randomized controlled trials (RCTs) that evaluated the LSVT intervention compared with other/no speech intervention were considered. The data obtained from the included studies were described and the mean differences were calculated. Eight RCTs were included in this meta‐analysis comparing LSVT with other/no speech interventions. In the comparison of LSVT versus no intervention, vocal intensity for sustained ‘Ah’ phonation, reading the ‘Rainbow passage’, monologue and describing a picture increased by 8.87, 4.34, 3.25 and 3.31 dB, respectively, after 1 month of therapy. Compared with the respiratory therapy group, the LSVT group also showed significant improvement in vocal intensity for sustained ‘Ah’ phonation, reading the ‘Rainbow passage’ and monologue immediately after treatment (13.39, 6.66 and 3.19 dB). Positive improvement still existed after 24 months. There was no difference in the therapeutic effect between face‐to‐face and online LSVT. The effectiveness of LSVT for dysarthria in patients with PD was verified in these trials. However, future RCTs with sufficient participants are essential to evaluate the effectiveness of LSVT for dysarthria.