bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes and predictors of resilience among wife and husband caregivers of patients with advanced cancer: A longitudinal study
Authors: Sun Haiyan , Wacharasin Chintana , Hengudomsub Pornpat , Nagai Ayano 
Published: February 2025

Background: Resilience as a dynamic process plays a significant role in caregivers’ mental health. Little is known about gender differences in the resilience process and predictors of resilience in spousal caregivers. Aim: To investigate changes in resilience among wives and husbands of patients with advanced cancer over a 6-month posttreatment period, and identify different predictors of resilience between females and males. Design: This longitudinal, observational study was conducted from January to December 2022. Setting/Participants: Spousal caregivers of patients with newly diagnosed advanced cancer were recruited from five regional tertiary hospitals in China. There were three assessment points at 1, 3, and 6 months post-initial treatment. The dependent variable was resilience, and five independent repeated variables were investigated. Results: Totally, 179 wife caregivers and 133 husband caregivers were included. Resilience in both wife caregivers and husband caregivers increased over time (Wald χ2 = 29.83, p < 0.001) but husbands had higher levels of resilience than wives (Wald χ2 = 35.59, p < 0.001). However, there was no interaction between time and gender (Wald χ2 = 5.25, p > 0.05). Patient functional status, caregiver burden, social support, coping self-efficacy, and mutuality were predictors of resilience for wife caregivers. Meanwhile, patient functional status, caregiver burden and coping self-efficacy could predict resilience for husband caregivers. Conclusions: Healthcare providers may develop gender-specific interventions to promote resilience in spousal caregivers of patients with advanced cancer. This would improve mental health for caregivers in the process of palliative care.
Single-dose psilocybin therapy for alcohol use disorder: Pharmacokinetics, feasibility, safety and efficacy in an open-label study
Authors: Jensen Mathias Ebbesen , Stenbæk Dea Siggaard , Messell Catharina Dragsted , Poulsen Emil Deleuran , Varga Tibor V , Fisher Patrick McDonald , Nielsen Marie Katrine Klose , Johansen Sys Stybe , Volkow Nora D , Knudsen Gitte Moos , Fink-Jensen Anders 
Published: February 2025

Background: Psilocybin, a serotonin 2A receptor agonist with psychedelic properties, shows promise as a novel treatment for alcohol use disorder (AUD). While current studies involve two dosing sessions, the effects of a single dose have not been investigated. Aims: To investigate the pharmacokinetics, feasibility, safety and efficacy of single-dose psilocybin therapy in AUD. Methods: This open-label, single-group study investigated single-dose psilocybin therapy in 10 treatment-seeking adults (8 men and 2 women; median age 44 years) with severe AUD. The treatment involved two preparation sessions, a high-dose psilocybin session (25 mg) and two integration sessions. Pharmacokinetics were determined by noncompartmental analysis, and changes in alcohol consumption, craving and self-efficacy, were assessed using a linear mixed model. Results: Notable between-participant pharmacokinetic variations were observed, with peak plasma psilocin concentrations ranging from 14 to 59 µg/L. Alcohol consumption significantly decreased over the 12 weeks following psilocybin administration. Heavy drinking days were reduced by 37.5 percentage points (95% CI: −61.1 to −13.9, p = 0.005), and drinks per day decreased by 3.4 drinks (95% CI: −6.5 to −0.3, p = 0.03). This was corroborated by reports of rapid and sustained reductions in craving and increases in self-efficacy. Conclusions: Despite pharmacokinetic variations, a single 25 mg psilocybin dose was safe and effective in reducing alcohol consumption in AUD patients. Larger randomised, placebo-controlled, single-dose AUD trials are warranted. Clinical trial registration: https://clinicaltrials.gov/study/NCT04718792
Methodological challenges in using screening tools for depression in migraine: A systematic review
Authors: Asheer Jasmin , Ali Fatima , Hilker Rikke , Videbech Poul , Schytz Henrik Winther 
Published: February 2025

Background Depression is frequently described to occur in migraine, and depression screening questionnaires are commonly used to evaluate depressive symptoms in patients with migraine. The present study aimed to investigate how the most common depression screening tools are used in migraine studies to determine whether they are applied and interpreted correctly. Methods PubMed was systematically searched, and we included any study using the Beck Depression Inventory (BDI), Patient Health Questionnaire-9 (PHQ-9), Hospital Anxiety Depression Scale (HADS) or Hamilton Depression Rating Scale (HAM-D). The study included adults diagnosed with migraine based on the International Classification of Headache Disorders (ICHD-2 or ICHD-3). Results The literature search generated 78 studies. Thirty-five (45%) of the included studies used a depression screening tool as evidence of depression. This applied to 53, 46, 47 and 13% of studies using PHQ, BDI, HADS and HAM-D, respectively. Only one study out of 35 confirmed the diagnosis with a diagnostic interview. The data presentation and interpretation across the studies was highly heterogeneous. Conclusions Screening tools as evidence of depression in patients with migraine may lead to inaccurate estimates of depression among migraine patients. There is a need for guidelines on and validation of depression screening tools in patients with migraine.
‘I Was Shattered and Broken’: Unmasking the Experiences and Responses of Black Canadian to Pregnancy Loss
Authors: Boakye Priscilla N. , Prendergast Nadia , Thomas Obewu Ola Abanta , Mugambi Diana 
Published: February 2025

Background Pregnancy loss remains an invisible tragedy that impacts on the psychosocial well-being of women and their families. Cultural norms and beliefs about pregnancy loss affect how some women respond and process the loss. Yet research about Black Canadian women's experiences of pregnancy loss is lacking. The purpose of this research was to explore Black Canadian women's experiences and responses to pregnancy loss. Methods A descriptive exploratory qualitative design was used to gain insight into the experiences of Black Canadian women. Semi-structured interviews were conducted with women who identified as Black. Data was analyzed using a thematic analysis approach. Results We purposely recruited and interviewed 32 Black Canadian women who experienced miscarriage, stillbirth, or neonatal death. Three overarching themes were identified: (a) coming to terms with the reality of losing a pregnancy, (b) grappling with the psychosocial burden of losing a pregnancy, and (c) navigating for support after losing a pregnancy. Conclusion Addressing the psychosocial burden of pregnancy loss is critical to promote the well-being of Black Canadian women. Nurses and other healthcare providers must recognize that the impact of pregnancy loss extends beyond the immediate clinical concerns. Therefore, intervention programs and follow up care must take a holistic and culturally responsive approach to address the needs of Black Canadian women beyond the period of the loss.
The Brain Lesion Affecting Dysphagia in Patient with Supratentorial Stroke
Authors: Kang Jeon-Woong , Lim Seong-Hoon , Jang Dae-Hyun , Kim Min-Wook , Kim Jaewon 
Published: February 2025

Background Dysphagia is a common sequela of stroke. However, specific swallowing impairments associated with brain lesions at different sites are not well characterized. Objective This study aimed to determine the relationship between the location of supratentorial brain lesions and the features of dysphagia. Methods Medical records of patients with first-ever supratentorial stroke who underwent videofluoroscopic swallowing studies within 4 weeks of onset were retrospectively analyzed. Results A total of 158 patients (92 men and 66 women) were included. The lesions in internal capsule were associated with prolonged pharyngeal delay time (odds ratio [OR] 4.02, 95% confidence interval [CI] 1.13–14.28) and were inversely associated with post-swallowing vallecular residue (OR 0.55, 95% CI 0.32–0.95). The lesions in the insular cortex were associated with premature spillage and prolonged pharyngeal delay time (OR 2.27, 95% CI 1.08–4.76; OR 2.29, 95% CI 1.05–4.99, respectively). The lesions in the frontal lobe were associated with oral residue, vallecular residue, and pyriformis residue (OR 3.16, 95% CI 1.63–6.10; OR 3.06, 95% CI 1.55–6.02; OR 2.57, 95% CI 1.28–5.15, respectively). Conclusions This study revealed specific patterns of swallowing associated with specific brain lesions. Our findings may help elucidate the correlation between dysphagia patterns and the sites of brain lesions.
The Effects of 8-week Dance and Tai Chi Randomized Controlled Trial on Balance, Wellbeing and Moods Among Healthy Adults Aged 18 to 60: A Study Protocol
Authors: Lu Jie , Ngo Jake K. , Devonport Tracey J. , Wyon Matthew A. 
Published: February 2025

Purpose: The aim of the proposed randomized controlled study is to compare the effects and efficacy of a dance, a Tai Chi and a waiting list control group intervention over an 8-week period on physical functions and mental benefits among non-clinical adults aged between 18 and 60. Method: A double-blind, randomized controlled trial will be adopted to evaluate the effects and efficacy of an 8-week dance intervention compared with Tai Chi and a control group on physical and mental benefits. Participants will be randomly assigned to 3 groups, dance, Tai Chi, and Control group, using stratified random sampling based on sex. Isometric Mid-thigh Pull (IMTP), Y-Balance test (YBT), Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS), and The Brunel Mood Scale (BRUMS) are utilized for collecting physical and mental data. All measurements will be conducted by research assistants blinded to participants’ group allocation and analysis will be carried out by statistician blinded to the group and test parameters. Expected result: Mental wellbeing parameters are predicted to be increasing during the learning phase and the physical parameters are predicted to have an improvement in the practising phase.
Electrosurgical In Situ Fenestration of Aortic Endograft
Authors: Bastianon Martina , Esposito Davide , Melani Caterina , Sila Endri , Baldino Giuseppe , Pratesi Giovanni 
Published: February 2025

Purpose: Endovascular interventions have become the primary choice for treating complex aortic pathologies, particularly with the use of fenestrated and branched endografts. However, limitations, such as manufacturing time have restricted their applicability in urgent situations. This has led to explore alternative off-the-shelf solutions, including in situ fenestration. Within this technical note, we describe technical aspects of in situ fenestration using electrosurgical guidewire, in both antegrade and retrograde approaches, explaining advantages and limitation compared with other in situ fenestration techniques. Technique: The technique involves standard main body endograft deployment followed by targeted in situ fenestration using an electrified guidewire. Two illustrative cases are presented to demonstrate the technical aspects and clinical outcomes of this procedure. Conclusion: Electrosurgical in situ fenestration emerges as an effective technique for urgent treatment of complex aortic diseases. Further research is warranted to validate its safety and durability in larger patient cohorts. Clinical Impact Electrosurgical in situ fenestration allows to expand the feasibility of complex endovascular repairs in emegency settings. Electrosurgical in situ fenestration combines the benefits of thermal methods, offering broad availability and lower costs. Compared to other in situ fenestration techniques, the proposed technology allows for the creation of extremely small fenestrations with minimal and precise tissue disruption.
Mechanical thrombectomy for acute ischemic stroke performed without continuous saline flushes and using moderate sedation: The TOOFAST technique
Authors: Porto Carl M , Teshome Abigail A , Feler Joshua R , Moldovan Krisztina , Fontanez Santos Santos , Torabi Radmehr , Jayaraman Mahesh V , Wolman Dylan N 
Published: February 2025

Background Rapid reperfusion is an important predictor of neurologic recovery in acute ischemic stroke due to large vessel occlusion (AIS-LVO) treated with mechanical thrombectomy (MT). We present a single-institution retrospective observational study of the ThrOmbectomy withOut Flushes or AnestheSia Teams (TOOFAST) technique, which eliminates continuous heparinized saline flushes and employs conscious sedation (CS) to streamline MT preparation. Methods Retrospective review of prospectively collected data for AIS-LVO patients at our comprehensive stroke center from January 1, 2020, to December 31, 2023. Patients were >18 years with premorbid modified Rankin Scale (mRS) <3. Cases were performed under CS without continuous pressurized heparinized saline flushes or anesthesiologist involvement. Cases were categorized as presenting to the emergency department or from inpatient units (in-house), outside hospital transfers, or those undergoing hyperacute MRI. Results Among 947 total cases, 638 were analyzed. 374 (58.6%) were in-house activations, 205 (32.1%) were transfers, and 59 (9.2%) underwent hyperacute MRI. Median presenting National Institutes of Health Stroke Scale (NIHSS) was 15 (interquartile range (IQR) 9–20) and 34.7% of patients received intravenous thrombolysis. Median arrival-to-access and NIR-to-access times for in-house activations were 67 (IQR 56–80) and 39 (IQR 29–48) minutes, respectively. Embolization to new territory occurred in 11 (1.7%) patients while vascular perforation occurred in 9 (1.4%). Median NIHSS shift from admission to discharge was −9 (IQR −15 to −5). At 90 days, 46.5% (106/228) remained mRS <3. Conclusions The TOOFAST technique may result in rapid access times with a profile of safety, procedural parameters, and neurologic outcomes comparable to published trial standards.
Correction of Distal Metatarsal Articular Angle in Hallux Valgus Surgery Utilizing a Minimally Invasive Extra-Articular Metaphyseal Distal Transverse Osteotomy
Authors: Encinas Rodrigo , Hall SarahRose , Edelman David , McMillen Tucker , Hurley Deborah , Kaplan Jonathan R. M. , Schipper Oliver N. , Jackson J. Benjamin , Gonzalez Tyler A. 
Published: February 2025

Hallux valgus deformity frequently presents with an increased distal metatarsal articular angle (DMAA) which may require additional correction. Minimally invasive hallux valgus surgery is often used in patients with increased DMAA. We hypothesized that the triplanar correction with the minimally invasive extra-articular metaphyseal distal transverse osteotomy (META) would improve the DMAA, in addition to the hallux valgus angle (HVA), intermetatarsal angle (IMA), and patient-reported outcomes. A retrospective chart review was performed on patients who underwent an META procedure for hallux valgus correction. The DMAA, HVA, IMA were measured on preoperative, 2-week postoperative, and final follow-up radiographs. Patient demographics, complications, and Patient-Reported Outcomes Measure Information System (PROMIS) pain, function, and mobility scores were recorded. Univariate analysis and t-test were used to describe measurements between DMAA, HVA, and IMA. Twenty-seven META osteotomies were performed on 25 patients. At the final follow-up, mean DMAA, HVA, IMA decreased from 9.73 ± 1.96 to 4.35 ± 0.85 degrees, 30.45 ± 7.91 to 6.59 ± 2.75 degrees, and 15.37 ± 3.67 to 3.72 ± 1.84 degrees, respectively (P < .001). The PROMIS pain scores significantly improved from 58.96 ± 6.00 to 49.69 ± 9.35 at the final follow-up (P < .001). These observations imply successful resolution of hallux valgus, with a single META procedure. This approach may be an alternative to open or multiple corrections of hallux valgus, while preserving improvement in functional outcomes. Level of Evidence: Level IV
Syndesmotic Screw Fixation Versus Suture Button Versus Tibiotalocalcaneal Nail Treatment in Syndesmotic Ankle Fractures: A Meta-Analysis
Authors: Cho Thomas , Yan Helen R. , Uematsu Michael , Harter Christian , Liu Jiayong 
Published: February 2025

Background Syndesmotic ankle fractures occur when damage to the syndesmosis complex is combined with a malleolar fracture. This can result in severe pain, weakness, and instability. Surgical interventions include syndesmotic screw fixation (SS), suture button fixation (SB), and tibiotalocalcaneal nail (TTC). This meta-analysis aims to compare the outcomes of these treatment methods for syndesmotic ankle fractures. Methods A literature search was conducted on PubMed and Embase for comparison studies that included at least 2 surgical interventions and at least one of the relevant functional outcomes and/or complication metrics until June 2024. The Olerud-Molander Ankle Score (OMAS) was used to compare functional outcomes, and it is a self-reported outcome measure that evaluates the symptoms and function of those with ankle fractures, while infections and reoperations were reported to compare complication outcomes. Statistical analyses were performed using Review Manager 5.4. A P-value ≤ .05 was considered statistically significant. The risk of bias was assessed with Review Manager 5.4. and the Newcastle-Ottawa scale. Results A total of 18 studies with a total of 1,040 patients were ultimately included in this study. The SS had a significantly higher OMAS 2-year follow-up compared to TTC. The TTC had a significantly lower infection rate compared to SS. The SB had a significantly higher OMAS at both 1-year and 2-year follow-ups than SS. The SB had a significantly lower reoperation rate compared to SS. The SB had a significantly higher OMAS at both 1-year and 2-year follow-ups than TTC. The SB had a significantly lower infection rate compared to TTC. Conclusion The SB emerges as the preferred treatment method for syndesmotic ankle fractures, while TTC stands as a viable alternative. The SB is recommended as the primary surgical intervention for patients with syndesmotic ankle fractures due to its superior clinical benefits when compared to TTC and SS. Levels of Evidence: 3
Aristotle wires for cannulating target vessels in paediatric neuro-interventional procedures: A case-control study
Authors: Bhatia KD , Blane T , Giarola B , Vedamuthu J , Carraro Do Nascimento V , Kim Y-J , Olsson G , Dexter M 
Published: February 2025

Background Paediatric neuro-interventional (PNI) procedures are markedly different to adult procedures and are more likely to be complicated by vasospasm. Traversing the complex tortuous anatomy in these fragile vessels requires both torque control and distal tip softness of the microwire. The Aristotle wires (Scientia Vascular Inc) are a new family of wires with design features offering both torque control and distal tip softness. We sought to assess the ability of these wires to achieve successful target vessel cannulation in paediatric patients. Methods The study design was a single-centre case-control study. We compared a case cohort of PNI procedures performed using the Aristotle wires (2023–24) with a control cohort using other wires (2022–23). The primary study outcome was successful cannulation of the target vessel (Yes/No) with a microcatheter. Results The Aristotle wires cohort consisted of 44 targeted vessels across 40 procedures in 20 patients (F = 8; mean age 6.9, SD 6.53 years). The other wires cohort consisted of 41 targeted vessels across 41 procedures in 19 patients (F = 6; mean age 4.3, SD 4.98 years). Successful cannulation of the target vessel was achieved in 43 of 44 target vessels (97.7%) in the Aristotle wires cohort and 34 of 41 target vessels (82.9%) in the other wires cohort ( p = .020). The rate of wire-related complications was significantly lower in the Aristotle wires cohort (0 of 44 vs 6 of 41 target vessels, p = .008). Conclusion Aristotle wires were associated with significantly better target vessel cannulation and lower wire-related complications than other wires in PNI procedures.
A comparison of the effect of three different comorbidity indices on overall survival in patients with chronic myeloid leukemia
Authors: Yalçın Cumali , Orhan Bedrettin , Candar Ömer , Çubukçu Sinem , Güllü Koca Tuba , Hunutlu Fazıl Çağrı , Yavuz Şeyma , Akyol Merve Nur , Ersal Tuba , Özkocaman Vildan , Özkalemkaş Fahir 
Published: February 2025

Aims: It was aimed at measuring the comorbidities of chronic myeloid leukemia (CML) patients at the time of diagnosis with different comorbidity indices and evaluating their effects on disease prognosis. Methods: The comorbidities of the patients were retrospectively screened and calculated in three different comorbidity indices: the ACE-27 Comorbidity Index, the Age-adjusted Charlson Comorbidity Index, and the Elixhauser Comorbidity Index. C-statistic was used to evaluate the ability of comorbidity indices to discriminate mortality. The relationship between the calculated scores and overall survival (OS) was evaluated with the Kaplan-Meier curve. Mortality risk was analyzed with a multivariate Cox regression model. Results: A total of 218 CML patients were evaluated, and 211 chronic-phase patients were included in this study. The median age of the patients was 56 years (21–89), and 53% were female. As initial tyrosine kinase inhibitors, 201 (95%) patients were treated with imatinib, 10 (5%) patients with nilotinib. The median follow-up was 94.50 (9–201) months. The median OS was not reached. The most common comorbid conditions were hypertension 23% ( n = 48), weight loss 19% ( n = 40), diabetes mellitus 13% ( n = 27), and cardiovascular disease 9% ( n = 19). C-statistic values were 0.76 for ACE-27, 0.41 for ACCI, and 0.32 for ECI scores. In the Cox regression model including comorbidity scores, mortality risk was higher in patients with moderate ACE-27 score (HR: 148.05; 95% CI: 7.89–2751.53; p = 0.012), severe ACE-27 score (HR: 232.36; 95% CI: 14.20–4793.20; p = 0.001), ECOG 3 score (HR: 34.62; 95% CI: 2.67–447.36; p = 0.007), and high ELTS score (HR: 27.52; 95% CI: 1.34–543.68; p = 0.031). Conclusion: This study showed that the ACE-27 Comorbidity Index is effective in predicting prognosis in CML patients. Therefore, comorbid conditions should be used more frequently as a prognostic marker at the time of diagnosis.