bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isparta İlinde Adli Geriatrik Ölümler: 2010 – 2018 Verileri
Authors: YILDIZ Abdulkadir , ÇAYLI Erdinç , KAYĞUSUZ Özgür Riza , KARA Gülsüm Hülya 
Published: January 2020

Amaç: Isparta’da postmortem inceleme yapılan 65 yaş ve üzeri adli geriatrik
ölümlerin ölüm orijini, nedeni ve mekanizmalarını belirleyerek geriatrik ölüm
olgularında adli otopsinin önemi ile yaşlı nüfusun sağlık ve sosyal sorunlarına
dikkat çekmek amaçlanmıştır.

Gereç ve Yöntem: Süleyman Demirel Üniversitesi Tıp Fakültesi Adli
Tıp Anabilim Dalında 01.01.2010 – 31.12.2018 tarihleri arasında adli ölü
muayene ve otopsisi yapılan 65 yaş ve üzeri 265 olgunun otopsi tutanakları
retrospektif incelenerek istatistiksel olarak değerlendirilmiştir.

Bulgular: Adli ölü muayenesi ve otopsi uygulanmış toplam 1172 olgudan
%22,6’sının 65 yaş ve üzeri kişilerden oluştuğu saptandı. Yaş ortalaması
76,71±7,33 olarak saptanan olguların %68,7’si erkekti. Olguların %41,1’inin
erken yaşlılık (65-74 yaş), %42,3’ünün orta yaşlılık döneminde (75-84 yaş) olduğu
belirlendi. %27,5’inin doğal orijinli, %72,5’inin ise zorlamalı ölümler olduğu,
doğal orijinli ölüm nedenleri arasında ilk sırayı %65,8 ile kardiyovasküler
hastalıkların aldığı, zorlamalı ölümlerin %88’inin kaza, %6,8’inin intihar,
%3,1’inin cinayet, %2,1’inin hayvan saldırısı orijinli olduğu tespit edildi. Olguların
%22,6’sında ölü bulunma öyküsü olduğu belirlendi.

Sonuç: Yaşlıların ölüm orijinlerinin, nedenlerinin
ve mekanizmalarının belirlenmesi, önüne geçilmesi mümkün olan nedenlere yönelik
sosyal ve sağlık tedbirlerinin alınmasını sağlayabilir. Kazalara bağlı ölüm
oranlarının yüksekliği dikkate alındığında yaşlılıkla birlikte ortaya çıkan,
hareket, denge ve dikkat kaybına bağlı ölümle sonuçlanan kazaların engellenmesi
için trafikte ve evde özel önlemler alınması gerekmektedir. Yine sosyal
izolasyonun önüne geçilmesi ile intihara bağlı ve bakım eksikliği sonucu meydana
gelebilecek doğal ölümlerin önüne geçilmesi de mümkün olabilecektir.
Os Efeitos do Jejum Intermitente nos Parâmetros Bioquímicos de Ratos Wistar
Authors: Chamorro André Luiz Jacques , Fujii Beatriz Kiyoko , Bacha Eduardo Machado , Lins Gabriel Cabral Valadares , Yamakawa Kawana Ribeiro , Bento Leda Márcia Araujo , Lorenzon Luiza Engel , Silva Maethany Nayandra Oliveira , Lima Rafaela Alves , Seraphim Victor Yukio Iwata , Asato William Barbosa Martins 
Published: January 2020

O presente estudo teve como objetivo avaliar as repercussões bioquímicas em ratos Wistar submetidos ao jejum intermitente por 15, 30 e 60 dias, modelo de dieta intercalada por períodos de restrição total de alimentação com períodos de alimentação ad libitum. O estudo foi realizado com 40 ratos Wistar, machos divididos em três grupos, todos recebendo a ração Nuvital®. Os ratos submetidos ao jejum intermitente tiveram esse tipo de dieta durante 3 dias na semana e nos demais dias tiveram acesso livre a ração e água. Os animais foram pesados semanalmente e, após o período de jejum intermitente, foram eutanasiados para a coleta de sangue e análise bioquímica (glicemia, triglicérides, colesterol total e frações). Houve redução significativa do peso e triglicerídeos nos animais do grupo de jejum em relação ao grupo controle durante 15 dias. Em relação ao grupo de 30 dias de jejum, houve redução significativa de colesterol total e HDL. Nos animais submetidos à dieta durante 60 dias, houve diminuição significativa de colesterol total e HDL, no entanto, o consumo de água aumentou consideravelmente. Conclui-se que o jejum intermitente durante 15 dias causou alterações bioquímicas favoráveis ao metabolismo desses animais. Palavras-chave: Jejum Intermitente. Restrição Calórica. Prevenção. AbstractThis experiment was conducted to evaluate the biochemical effects in healthy Wistar rats submitted by 15, 30 and 60 days to intermittent fasting, a model of interspersed diet between periods of total food restriction withfood ad libitum period. The study was performed with 40 male Wistar rats randomly divided into 3 groups, all receiving Nuvital®. The rats submitted to intermittent fasting had this type of diet during 3 days a week and on the other days had free access to food. They received water ad libitum every day. The analysis related to metabolic changes resulting from fasting were performed by means of serum biochemical analysis (blood glucose, triglycerides, total cholesterol and HDL) at the end of the experiment. There was a significant reduction of weight and triglycerides from the fasting group in relation to the control group in 15 days, there was no significant increase in parameters during this period of diet. Concerning the 30-day fasting group, there was a significant reduction of total cholesterol and HDL. Therefore, Intermittent Fasting in 15 days only demonstrated biochemical benefits. Keywords: Intermittent Fasting. Caloric restriction. Prevention.
Contemporary Aspects of Financial – Banking Responsibility
Authors: Doina Bratu Renate 
Published: January 2020

We all as individuals have responsibility for any decisions, in terms of time, value and risk. In time, the system in which we are evolving requires different behaviors that are in alignment with our interests, as individuals, as organizations or as institutions. The paper brings into attention the concept of financial responsibility manifested in financial – banking environment, as a concept and as a species of financial education (or literacy). The main aim of this article is to evaluate the awareness, the manifestation and the importance of financial responsibility in Romania. The primary results reveal the fact that financial responsibility can improve the positive effects on individual’s welfare, and also the good impact that the financial system has on market economy. Moreover, here it is also evaluating the impact of financial education on the financial responsibility manifestation, as well as the theoretical interdependence ratio between those two terms – financial responsibility and financial education/literacy.
Keywords: financial – banking responsibility, moral hazard, financial education.
ECONOMIA REGIONAL E FINANCEIRIZAÇÃO: UMA AGENDA DE PESQUISA
Authors: Alencar Douglas , Taques Fernando Henrique , Jayme Jr Frederico Gonzaga , Strachman Eduardo 
Published: January 2020

O processo de financeirização da economia é cada vez mais claro com o crescimento do papel do crédito na economia, ao mesmo tempo em que alcança do desenvolvimento dos mercados financeiros e as instituições atreladas a ele. Nesse sentido, os desdobramentos regionais também podem ser sentidos, uma vez que o sistema abrange cada vez mais indivíduos e famílias com produtos direcionados para as necessidades diversas. Assim, o objetivo dessa pesquisa consiste em compreender as perspectivas teóricas de financeirização e discutir suas implicações em perspectiva local. Para tanto, a metodologia empregada consiste em revisão bibliográfica das abordagens teóricas sobre o tema. Os resultados sugerem que a perspectiva regional ainda precisa avançar na literatura para envolver o papel de políticas monetárias e o próprio desenvolvimento das regiões.
Kepribadian Guru Pendidikan Agama Islam Menurut Buya Hamka
Authors: Hamidah Laila , Siregar Sawaluddin , Nuraini Nuraini 
Published: January 2020

The teacher is a position or profession that requires special skills as a teacher. This work cannot be done by people who do not have the expertise to carry out activities or work as a teacher. Every teacher has a different personality and background and teaching experience. Every teacher has a personality according to the characteristics they have. Personality is actually an abstract, can only be seen through appearance, action, speech, how to dress, and how to deal with every problem. The teacher's personality is the main capital in carrying out the role and duty as an educator. Personality, character is a crown for a human, because that is what distinguishes humans from animals. Good character does not just appear, it is a lifelong learning process. To grow good character, a teacher can learn about the lives of characters who are considered to have good character or personality. Buya Hamka is a National figure who can be a role model in learning to have a great character and personality. The research conducted was included in the type of qualitative descriptive research with library research. The method used is critical analytical descriptive, the primary data source is the works of Buya Hamka who deal with professional teachers and the secondary data are similar works that have the same theme. The analysis in this study uses the method of content analysis. The results of the study are that the teacher according to Hamka functions as an institution that seeks to develop all the potential that exists in students to the fullest, in accordance with the rhythms of their development, both physicaly and mental spiritual have a good personality because students will imitate the behavior of his teacher. Teacher's Personality in Islamic Education According to Buya Hamka's Thought, the teacher must understand the concept of the educator as an exemplary subject, the tasks of the educator, and have character (traits), as befits an educator. Hamka expressed his opinion about how should the characteristics of Islamic religious education teachers, namely: 1) Having extensive knowledge, 2) Good communication, 3) Good example for students and those around them, 4) Ikhlash, 5) Having good methods for teaching, 6) Humility, 7) Responsibility, 8) Confidence, 9) Gentleness, 10) Patience, 11) Passion, 12) Apply and say honestly. Relevance of Hamka's Thought about the Teacher's Personality of Islamic Education with Education Today Teachers should help shape the character, mind, character, and personality of students, so that he knows which is good and what is bad. While Islamic teaching is an attempt to fill the intellectuals of students with a number of knowledge. Keyword: Teacher Personality, Buya Hamka
Fully Immersive Virtual Reality for Total Hip Arthroplasty
Authors: Logishetty Kartik , Gofton Wade T. , Rudran Branavan , Beaulé Paul E. , Cobb Justin P. 
Published: January 2020

Background:
Fully immersive virtual reality (VR) uses headsets to situate a surgeon in a virtual operating room to perform open surgical procedures. The aims of this study were to determine (1) if a VR curriculum for training residents to perform anterior approach total hip replacement (AA-THR) was feasible, (2) if VR enabled residents’ performance to be measured objectively, and (3) if cognitive and motor skills that were learned with use of VR were transferred to the physical world.

Methods:
The performance of 32 orthopaedic residents (surgical postgraduate years [PGY]-1 through 4) with no prior experience with AA-THR was measured during 5 consecutive VR training and assessment sessions. Outcome measures were related to procedural sequence, efficiency of movement, duration of surgery, and visuospatial precision in acetabular component positioning and femoral neck osteotomy, and were compared with the performance of 4 expert hip surgeons to establish competency-based criteria. Pretraining and post-training assessments on dry bone models were used to assess the transfer of visuospatial skills from VR to the physical world.

Results:
Residents progressively developed surgical skills in VR on a learning curve through repeated practice, plateauing, on average, after 4 sessions (4.1 ± 0.6 hours); they reached expert VR levels for 9 of 10 metrics (except femoral osteotomy angle). Procedural errors were reduced by 79%, assistive prompts were reduced by 70%, and procedural duration was reduced by 28%. Dominant and nondominant hand movements were reduced by 35% and 36%, respectively, and head movement was reduced by 44%. Femoral osteotomy was performed more accurately, and acetabular implant orientation improved in VR assessments. In the physical world assessments, experts were more accurate than residents prior to simulation, but were matched by residents after simulation for all of the metrics except femoral osteotomy angle. The residents who performed best in VR were the most accurate in the physical world, while 2 residents were unable to achieve competence despite sustained practice.

Conclusions:
For novice surgeons learning AA-THR skills, fully immersive VR technology can objectively measure progress in the acquisition of surgical skills as measured by procedural sequence, efficiency of movement, and visuospatial accuracy. Skills learned in this environment are transferred to the physical environment.
Wound Irrigation for Open Fractures
Authors: Heckmann Nathanael , Simcox Trevor , Kelley Daniel , Marecek Geoffrey S. 
Published: January 2020

» The optimal regimen for wound irrigation in the setting of an open fracture has been a subject of debate. Basic science evidence as well as results from a recent prospective clinical trial have shed new light on this controversial topic.» While normal saline solution appears to be the optimal irrigation agent, the optimal timing and volume often are determined by the surgeon. Future clinical trials are needed to determine the optimal timing for debridement and irrigation, as well as the ideal volume of irrigant.» Irrigation pressure and the use of pulsatile lavage do not appear to have an effect on outcomes.
Seroprevalence of Hepatitis B Virus among antenatal clinic attendees in Gamawa Local Government Area, Bauchi State, Nigeria
Authors: MUSTAPHA GARBA UMAR , Ibrahim Abdulrasul , Balogun Muhammad Shakir , Umeokonkwo Chukwuma David , Mamman Aisha Indo 
Published: January 2020

Abstract

Background: Hepatitis B virus disease is a potentially life-threatening liver infection and a major global health problem. It causes chronic infection and puts people at high risk of death from cirrhosis and liver cancer. WHO estimated 257 million people are living with hepatitis B virus (HBV) infection and in 2015 alone HBV resulted in to 887,000 deaths globally. We determined the prevalence and associated factors of hepatitis B virus infection among Antenatal Care (ANC) attendees in Gamawa Local Government Area, Bauchi State.
Methods: We conducted a descriptive cross-sectional, health facility-based study between March and April 2018. We used systematic random sampling technique to recruit 210 pregnant women aged 15-49 years. With a structured questionnaire, we interviewed the respondents and collected blood sample to test for hepatitis B surface antigen. We calculated frequencies, means, proportions, and tested for associations using Epi Info 7.2 and Microsoft Excel.
Results: The mean age of respondents was 24.5 ± 6.0 years; 112 (53%) of whom were younger than 25 years. All were married, 183 (87%) had no formal education and up to 190 (90%) were employed. Overall, 14 (6.7%) tested positive for HBsAg; women aged ≥35 years had the highest prevalence (10%). None with tertiary education tested positive and women married before 18 years had 13 (6.2%) prevalence.
Conclusions: The prevalence of HBsAg among pregnant women in Gamawa LGA was 6.7% which is quite lower than the national prevalence reported. We recommended improved surveillance of HBV infection and screening of women attending ANC.
Keywords: Hepatitis B virus, Hepatitis B Surface antigen, Prevalence, Pregnancy, Health facilities, Hepatitis B
Evaluating the impact of the weather conditions on the influenza propagation
Authors: Singh David E. , marinescu maria-cristina , Carretero Jesus , Delgado-Sanz Concepcion , Gomez-Barroso Diana , Larrauri Amparo 
Published: January 2020

Abstract
Background: Predicting the details of how an epidemic evolves is highly valuable as health institutions need to better plan towards limiting the infection propagation effects and optimizing their prediction and response capabilities. Simulation is a cost- and time-effective way of predicting the evolution of the infection as the joint influence of many different factors: interaction patterns, personal characteristics, travel patterns, meteorological conditions, previous vaccination, etc. The work presented in this paper extends EpiGraph, our influenza epidemic simulator, by introducing a meteorological model as a modular component that interacts with the rest of EpiGraph's modules to refine our previous simulation results. Our goal is to estimate the effects of changes in temperature and relative humidity on the patterns of epidemic influenza based on data provided by the Spanish Influenza Sentinel Surveillance System (SISSS) and the Spanish Meteorological Agency (AEMET). Methods: Our meteorological model is based on the regression model developed by Barreca and Shimshack, and it is tuned with influenza surveillance data obtained from SISSS. After pre-processing this data to clean it and reconstruct missing samples, we obtain new values for the reproduction number of each urban region in Spain, every 10 minutes during 2011. We simulate the propagation of the influenza by setting the date of the epidemic onset and the initial influenza-illness rates for each urban region. Results: We show that the simulation results have the same propagation shape as the weekly influenza rates as recorded by SISSS. We perform experiments for a realistic scenario based on actual meteorological data from 2010-2011, and for synthetic values assumed under simplified predicted climate change conditions. Results show that a diminishing relative humidity of 10\% produces an increment of about 1.6\% in the final infection rate. The effect of temperature changes on the infection spread is also noticeable, with a decrease of 1.1\% per extra degree. Conclusions: Using a tool like ours could help predict the shape of developing epidemics and its peaks, and would permit to quickly run scenarios to determine the evolution of the epidemic under different conditions. We make EpiGraph source code and epidemic data publicly available.
Assessment of branch point prediction tools to predict physiological branch points and their alteration by variants
Authors: Leman Raphael , Tubeuf Hélène , Raad Sabine , Tournier Isabelle , Derambure Céline , Lanos Raphaël , Gaildrat Pascaline , Castelain Gaia , Hauchard Julie , Killian Audrey , Baert-Desurmont Stéphanie , Legros Angelina , Goardon Nicolas , Quesnelle Céline , Ricou Agathe , Castera Laurent , Vaur Dominique , Gac Gérald Le , Ka Chandran , Fichou Yann , Bonnet-Dorion Françoise , Sevenet Nicolas , Guillaud-Bataille Marine , Boutry-Kryza Nadia , Schultz Ines , Caux-Moncoutier Virginie , Rossing Maria , Walker Logan C , Spurdle Amanda B , Houdayer Claude , Martins Alexandra , Krieger Sophie 
Published: January 2020

Abstract
Background: Branch points (BPs) map within short motifs upstream of acceptor splice sites (3’ss) and are essential for splicing of pre-mature mRNA. Several BP-dedicated bioinformatics tools, including HSF, SVM-BPfinder, BPP, Branchpointer, LaBranchoR and RNABPS were developed during the last decade. Here, we evaluated their capability to detect the position of BPs, and also to predict the impact on splicing of variants occurring upstream of 3’ss.
Results: We used a large set of constitutive and alternative human 3’ss collected from Ensembl (n = 264,787 3’ss) and from in-house RNAseq experiments (n = 51,986 3’ss). We also gathered an unprecedented collection of functional splicing data for 120 variants (62 unpublished) occurring in BP areas of disease-causing genes. Branchpointer showed the best performance to detect the relevant BPs upstream of constitutive and alternative 3’ss (99.48 % and 65.84 % accuracies, respectively). For variants occurring in a BP area, BPP emerged as having the best performance to predict effects on mRNA splicing, with an accuracy of 89.17 %.
Conclusions: Our investigations revealed that Branchpointer was optimal to detect BPs upstream of 3’ss, and that BPP was most relevant to predict splicing alteration due to variants in the BP area.
Keywords: Branch Point, Prediction, RNA, Benchmark, HSF, SVM-BPfinder, BPP, Branchpointer, LaBranchoR, RNABPS, Variants
Increased plasma concentration of cell-free DNA precedes disease recurrence in children with high-risk neuroblastoma
Authors: Su Yan , Wang Lijun , Jiang Chiyi , Yue Zhixia , Fan Hongjun , Hong Huimin , Duan Chao , Jin Mei , Zhang Dawei , Qiu Lihua , Cheng Xianfeng , Xu Zhong , Ma Xiaoli 
Published: January 2020

Abstract
Background: Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent need to identify effective predictive biomarkers of disease recurrence.
Methods: A total of 116 patients with high-risk neuroblastoma were recruited at Beijing Children’s Hospital between February 2015 and December 2017. All patients received multidisciplinary treatment, were evaluated for the therapeutic response, and then initiated on maintenance treatment. Blood samples were collected at the beginning of maintenance treatment, every 3 months thereafter, and at the time of disease recurrence. Plasma levels of cell-free DNA (cfDNA) were quantified by qPCR. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of plasma cfDNA concentration to predict recurrence.
Results: Of the 116 patients, 36 (31.0%) developed recurrence during maintenance treatment. The median time to recurrence was 19.00, 9.00, and 8.00 months for patients who had achieved complete response (n = 6), partial response (n = 25), and stable disease (n = 5), respectively, after multidisciplinary treatment. The median plasma cfDNA concentration at the time of recurrence was significantly higher than the concentration in recurrence-free patients throughout maintenance treatment (29.34 ng/mL vs 10.32 ng/mL). Patients recorded a plasma cfDNA level ≥29 ng/mL an average of 0.55 months before diagnosis of disease recurrence. ROC analysis of the power of plasma cfDNA to distinguish between patients with or without recurrence yielded an area under the curve of 0.825, with optimal sensitivity and specificity of 80.6% and 71.3%, respectively, at a cfDNA level of 12.93 ng/mL.
Conclusions: High plasma cfDNA concentration is a potential molecular marker to signal disease recurrence in patients with high-risk neuroblastoma.
Inflammation biomarker discovery in Parkinson's disease and atypical parkinsonisms
Authors: Santaella Anna , Kuiperij H. Bea , Rumund Anouke van , Esselink Rianne A.J. , Gool Alain J. van , Bloem Bas R. , Verbeek Marcel 
Published: January 2020

Abstract
Background: Parkinson’s disease (PD) and atypical parkinsonisms (APD) have overlapping symptoms challenging an early diagnosis. Diagnostic accuracy is important because PD and APD have different prognosis and response to treatment. We aimed to identify diagnostic inflammatory biomarkers of PD and APD in cerebrospinal fluid (CSF) using the multiplex proximity extension assay (PEA) technology and to study possible correlations of biomarkers with disease progression.

Methods: CSF from a longitudinal cohort study consisting of PD and APD patients (PD, n = 44; multiple system atrophy (MSA), n = 14; vascular parkinsonism (VaP), n = 9; and PD with VaP, n = 7) and controls (n = 25) were analyzed.

Results: Concentrations of CCL28 were elevated in PD compared to controls (p = 0.0001). Five other biomarkers differentiated both MSA and PD from controls (p < 0.05) and 10 biomarkers differentiated MSA from controls, of which two proteins, i.e. beta nerve growth factor (β-NGF) and Delta and Notch like epidermal growth factor-related receptor (DNER), were also present at lower levels in MSA compared to PD (both p = 0.032). Two biomarkers (MCP-1 and MMP-10) positively correlated with PD progression (rho > 0.650; p < 0.01).

Conclusions: PEA technique identified potential new CSF biomarkers to help to predict the prognosis of PD. Also, we identified new candidate biomarkers to distinguish MSA from PD.