bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tubulin Maytansine Site Binding Ligands and their Applications as MTAs and ADCs for Cancer Therapy
Authors: Cao Shuo , Dong Yue-Hui , Wang De-Feng , Liu Zhao-Peng 
Published: March 2020

Background:
Microtubule Targeting Agents (MTAs) represent the most successful
anticancer drugs for cancer chemotherapy. Through interfering with the tubulin polymerization
and depolymerization dynamics, MTAs influence intracellular transport and cell signal pathways,
inhibit cell mitosis and cell proliferation, and induce cell apoptosis and death. The tubulin maytansine
site binding agents are natural or nature-derived products that represent one type of the
MTAs that inhibit tubulin polymerization and exhibit potent antitumor activity both in vitro and
in vivo. They are used as Antibody-Drug Conjugates (ADCs) in cancer chemotherapy.

Methods:
Using SciFinder® as a tool, the publications about maytansine, its derivatives, maytansine
binding site, maytansine site binding agents and their applications as MTAs for cancer
therapy were surveyed with an exclusion on those published as patents. The latest progresses in
clinical trials were obtained from the clinical trial web.

Results:
This article presents an introduction about MTAs, maytansine, maytansine binding site
and its ligands, the applications of these ligands as MTAs and ADCs in cancer therapy.

Conclusion:
The maytansine site binding agents are powerful MTAs for cancer chemotherapy.
The maytansine site ligands-based ADCs are used in clinic or under clinical trials as cancer targeted
therapy to improve their selectivity and to reduce their side effects. Further improvements
in the delivery efficiency of the ADCs will benefit the patients in cancer targeted therapy.
In Silico Transcriptomic Analysis of the Chloride Intracellular Channels (CLIC) Interactome Identifies a Molecular Panel of Seven Prognostic Markers in Patients with Pancreatic Ductal Adenocarcinoma
Authors: Magouliotis Dimitrios E. , Sakellaridis Nikos , Dimas Konstantinos , Tasiopoulou Vasiliki S. , Svokos Konstantina A. , Svokos Alexis A. , Zacharoulis Dimitris 
Published: March 2020

Background:
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis.
In this context, the identification of biomarkers regarding the PDAC diagnosis, monitoring, and prognosis
is crucial.

Objectives:
The purpose of the current study was to investigate the differential gene expression profile
of the chloride intracellular channel (CLIC) gene family network in patients with PDAC, in order to
suggest novel biomarkers.

Methods:
In silico techniques were used to construct the interactome of the CLIC gene family, identify
the differentially expressed genes (DEGs) in PDAC as compared to healthy controls, and evaluate
their potential prognostic role.

Results:
Transcriptomic data of three microarray datasets were included, incorporating 114 tumor and
59 normal pancreatic samples. Twenty DEGs were identified; eight were up-regulated and twelve
were downregulated. A molecular signature of seven genes (Chloride Intracellular Channel 1 –
CLIC1; Chloride Intracellular Channel 3 – CLIC3; Chloride Intracellular Channel 4 – CLIC4; Ganglioside
Induced Differentiation Associated Protein 1 – GDAP1; Ganglioside Induced Differentiation
Associated Protein 1 Like 1 – GDAP1L1; Glutathione S-Transferase Pi 1 - GSTP1; Prostaglandin E
Synthase 2 – PTGES2) were identified as prognostic markers associated with overall survival. Positive
correlations were reported regarding the expression of CLIC1-CLIC3, CLIC4-CLIC5, and CLIC5-
CLIC6. Finally, gene set enrichment analysis demonstrated the molecular functions and miRNA families
(hsa-miR-122, hsa-miR-618, hsa-miR-425, and hsa-miR-518) relevant to the seven prognostic
markers.

Conclusions:
These outcomes demonstrate a seven-gene molecular panel that predicts the patients’
prospective survival following pancreatic resection for PDAC.
The SNPs within 3'UTR of miRNA Target Genes Related to Multiple Sclerosis: A Computational Prediction
Authors: Zafarpiran Mina , Sharifi Roya , Shirvani-Farsani Zeinab 
Published: March 2020

Background:
Multiple Sclerosis (MS) is an inflammatory and demyelinating
disease of the central nervous system, and genetic factors play an important role in its susceptibility.
The expressions of many inflammatory genes implicated in MS are regulated
by microRNA (miRNAs), whose function is to suppress the translation by pairing with
miRNA Recognition Elements (MREs) present in the 3' untranslated region (3'UTR) of
target mRNA. Recently, it has been shown that the Single Nucleotide Polymorphism
(SNPs) present within the 3'UTR of mRNAs can affect the miRNA-mediated gene regulation
and susceptibility to a variety of human diseases.

Objective:
The aim of this study was to analyze the SNPs within the 3'UTR of miRNA inflammatory
target genes related to multiple sclerosis.

Methods:
By DisGeNET, dbGaP, Ovid, DAVID, Web of knowledge, and SNPs databases,
3'UTR genetic variants were identified in all inflammatory genes associated with MS. Also,
miRNA's target prediction databases were used for predicting the miRNA binding sites.

Results:
We identified 125 SNPs with MAF>0.05 located in the binding site of the miRNA
of 35 genes among 59 inflammatory genes related to MS. Bioinformatics analysis
predicted 62 MRE-modulating SNPs and 59 MRE-creating SNPs in the 3'UTR of MSimplicated
inflammatory genes. These candidate SNPs within miRNA binding sites of inflammatory
genes can alter the miRNAs binding, and consequently lead to the mRNA
gene regulation.

Conclusion:
Therefore, these miRNA and MRE-SNPs may play important roles in personalized
medicine of MS, and hence, they would be valuable for further functional verification
investigations.
Aqueous Asteriscus graveolens Extract Exhibits Antidiabetic and Hepatoprotective Effects in Diabetic Rats
Authors: El-Ouady Fadwa , Eddouks Mohamed 
Published: March 2020

Background:Asteriscus graveolens (A. graveolens) is a medicinal plant with numerous applications in phytotherapy including diabetes management. However, the antidiabetic effect of this plant has never been investigated experimentally.Objective:The objective of this study was to evaluate the antidiabetic effect of aqueous extract prepared from the aerial part of Asteriscus graveolens (A. graveolens) in normal and STZ-induced diabetic rats.Method:The effect of a single dose and daily oral administration for 15 days of the aerial part aqueous extract of A. graveolens (AGAPE) (10 mg/kg) on blood glucose levels was evaluated. In addition, histopathological examination of the liver as well as the in vitro antioxidant activity AGAPE were performed.Results:The data illustrate that both single and repeated oral administration of AGAPE were able to reduce blood glucose levels in normal and diabetic rats. The extract ameliorated histopathological properties of liver in diabetic rats and it exhibited in vitro antioxidant activity.Conclusion:In conclusion, the present investigation revealed for the first time that A. graveolens possesses potent antidiabetic and hepatoprotective activities which support the traditional claim of the plant.
Effect of Coenzyme Q10 Supplementation on Urinary and Salivary Oxidative Stress Biomarkers in Bipolar Patients During the Depressive Episode
Authors: Hosseini-Ghalibaf Seyyede-Nadia , Ranjbar Akram , Yasrebifar Fatemeh , Mirzaei Ehsan , Mirjalili Mahtabalsadat , Mohammadi Younes , Mehrpooya Maryam 
Published: March 2020

Background:
Although depression is the predominant phase in Bipolar Disorder (BPD)
and causes the most psychosocial disability, optimal pharmacotherapy of bipolar depression is not
known yet. Advances in research on BPD neurobiology have demonstrated that oxidative toxic
stress (OTS) may be involved in the pathophysiology of BPD.

Objective:
The present study aimed to evaluate the effects of adjuvant CoQ10, supplement with potent
antioxidant properties, on salivary and urinary OTS biomarkers in patients with BPD during the
depressive episode.

Material and Methods:
89 BPD patients with current depressive episode were allocated into either
CoQ10 (200 mg/day) or placebo group by block randomization method. The salivary and urinary
levels of OTS biomarkers including Total Antioxidant Capacity (TAC) and DNA damage were
measured at baseline and 8 weeks after treatment.

Results:
At baseline, urinary and salivary levels of TAC and DNA damage were statistically comparable
between the two groups. After 8 weeks treatment with CoQ10, patients showed significantly
higher increment in urinary TAC level compared to placebo, while salivary level of TAC did not
display significant differences between the two groups. Although changes in salivary and urinary
DNA damage levels were greater in CoQ10 group, the changes reached significant level only in the
urine sample.

Conclusion:
Our findings suggest that CoQ10 can improve OTS status in BPD patients during depressive
episode. As activation of oxidative stress is one of the mechanisms responsible for BPD, it
seems that CoQ10 due to its proven antioxidant properties, as add on therapy to standard treatment
may be a promising agent in treating bipolar depression.
Impact of Annealing Temperature on Structural, Optical, and Morphological Properties of ZnO Nanoparticles Synthesized by a Simple Precipitation Method
Authors: Deshmukh Lalita D. , Chavan Kalyan B. 
Published: March 2020

Objective:
Herein, we report zinc oxide (ZnO) nanoparticles (NPs) synthesized by a
simple precipitation method using zinc acetate dihydrate (Zn(CH3CO2)2. 2H2O) and sodium hydroxide
(NaOH) precursors in aqueous media.

Method:
Synthesized material was annealed at different temperatures to check phase formation
and its purity.

Results:
At room temperature, the sample shows the formation of zinc hydroxide and at high temperature
(100, 200, and 300°C) shows the formation of ZnO. Synthesized materials were analyzed
by different techniques. X-ray diffraction analysis shows the formation of a hexagonal crystal
structure. Morphological features were analyzed by the SEM technique which shows agglomerated
nanoparticles.

Conclusion:
The optical properties of ZnO were studied by using UV analysis and showed intrinsic
excitonic transition property of the ZnO semiconductor. Further, with an increase in annealing
temperature crystalline size, agglomeration of nanoparticles found to be increased whereas the
bandgap decreased.
A Study of Metabolic Syndrome in Patients on Risperidone
Authors: Thangraj Ajay , Desai Nimesh G. , Singh Vijender 
Published: March 2020

Background:
Novel antipsychotics are superior to conventional antipsychotics,
as they significantly reduce both positive and negative symptoms of schizophrenia and
have lower risk of extra pyramidal syndrome (EPS). However, these drugs cause significant
metabolic side effects.

Objective:
This study was carried out to assess the hospital prevalence of metabolic syndrome
(MetS) and metabolic profile related to use of oral risperidone which is one of the
most commonly used atypical antipsychotics.

Methods:
A cross-sectional study was carried out on a period sample of 6 months, to study
the hospital prevalence and profile of MetS in adult patients on oral risperidone. Data was
collected from pharmacy dispensing records, patients’ case record files, and subsequently
patients were contacted telephonically and called to participate in this study.

Results:
Hospital prevalence of MetS was found to be 12.1% (13 out of 107) by NCEP
ATP III criteria and 14.9% (16 out of 107) by IDF criteria in patients (aged 20 to 40 years)
on risperidone. Ninety one patients (85%) of the sample were found to be in Overweight
category and Central Obesity was found in 82(76.6%) patients. Twenty three (21.4%) of
the patients had increased triglyceride (TG) levels. Out of the 16 patients with MetS,
11(68.75%) of them had total duration of illness (TDI) of >4 years, 11(68.75%) were in
30-40 years age group, 13 (81.25%) of them had continued illness or they were in partial
remission, 11 (68.75%) of them were already exposed to any antipsychotics other than
risperidone, 6(37.5%) of them were having diabetes mellitus (DM) in one parents.

Conclusion:
This study reported the hospital prevalence of MetS as 14.9% (IDF criteria) in
young adult patients on oral risperidone. The triglyceride levels and central obesity was also
found to be higher in patients, who otherwise had low prevalence of MetS.
Magnetic Nanoparticles; Synthesis, Properties and Electrochemical Application: A Review
Authors: Roostaee Maryam , Sheikhshoaie Iran 
Published: March 2020

Background:The Fe3O4 nanoparticles have been highly regarded in recent years due to their unique properties and different applications. Magnetic separation capability of Fe3O4 nanoparticles provides an environmentally friendly procedure for the synthesis of this nanoparticle and its derivatives.Objective:There are many methods for synthesizing magnetic nanoparticles, and the properties of these nanoparticles are largely dependent on their synthesis method. Magnetite has many applications in various fields, one of the most important of which is the application of electrochemical sensors. These nanoparticles attached to the surface of different electrodes and used for the sensitive and selective electrochemical determination of trace amounts of several combinations. In this review paper, recently suggested synthesis methods of Fe3O4 and its derivatives and their electrochemical application are discussed.
Whole Grains, Dietary Fibers and the Human Gut Microbiota: A Systematic Review of Existing Literature
Authors: Tangestani Hadith , Emamat Hadi , Ghalandari Hamid , Shab-Bidar Sakineh 
Published: March 2020

Background:
The health benefits of dietary fibers have been proved for a long time. The
importance of microbiota has been identified in human health and there is a growing interest to
study the factors affecting it.

Objective:
This systematic review aimed to investigate the impact of fiber and whole grains (WGs)
on human gut microbiota in a patent-based review.

Methods:
All related clinical trials were systematically searched on PubMed and Scopus search engines
from inception up to Feb 2020. Interventional human studies reporting changes in microbiota
by using any type of grains/fibers were included. The following information was extracted: date of
the publication, location and design of the study, sample size, study population, demographic characteristics,
the amount of dietary WGs/fiber, the duration of intervention, the types of grains or fibers,
and changes in the composition of the microbiota.

Results:
Of 138 studies which were verified, 35 studies with an overall population of 1080 participants,
met the inclusion criteria and entered the systematic review. The results of interventional trials
included in this review suggest some beneficial effects of consuming different amounts and
types of WGs and fibers on the composition of intestinal microbiota. Most included studies showed
that the intake of WGs and fibers increases bifidobacteria and lactobacilli and reduces the pathogenic
bacteria, such as Escherichia coli and clostridia in the human gut.

Conclusion:
The consumption of WGs/fibers may modify the intestinal microbiota and promote
the growth of bifidobacteria and lactobacilli. Nevertheless, further research is warranted in different
populations and pathological conditions.
Visual Target Tracking via Online Reliability Evaluation and Feature Selection in the Framework of Correlation Filtering
Authors: Wei Li , Ding Meng , Cao Yun-Feng , Zhang Xu 
Published: March 2020

Background:
Although correlation filtering is one of the most successful visual tracking
frameworks, it is prone to drift caused by several factors such as occlusion, deformation and
rotation.

Objective:
In order to improve the performance of correlation filter-based trackers, this paper proposes
a visual tracking method via online reliability evaluation and feature selection.

Methods:
The main contribution of this paper is to introduce three schemes in the framework of correlation
filtering. Firstly, we present an online reliability evaluation to assess the current tracking
result by using the method of adaptive threshold segmentation of response map. Secondly, the proposed
tracker updates the regression model of correlation filter according to the assessment result.
Thirdly, when the tracking result based on a handcrafted feature is not reliable enough, we propose a
feature selection scheme that autonomously replaces a handcrafted feature used in the traditional
correlation filter-based trackers with a deep convolutional feature that can re-capture the target by its
powerful discriminant ability.

Results:
On OTB-2013datasets, the Precision rate and Success rate of the proposed tracking algorithm
can reach 84.8% and 62.5%, respectively. Moreover, the tracking speed of proposed algorithm
is 19 frame per second.

Conclusion:
The quantitative and qualitative experimental results both demonstrate that the proposed
algorithm performed favorably against nine state-of-the-art algorithms.
EVALUATION AND PATHOBIOLOGICAL SIGNIFICANCE OF ZINC, SELENIUM, AND PLATELET LEVELS IN SICKLE CELL ANEMIA
Authors: JOHNKENNEDY NNODIM , JOSEPH NJOKU CHUKWUDI , NKIRUKA OLY-ALAWUBA , CHIDOZIE NWAOKORO JOAKIN , JOY AMADI , NGOZIKA C OKECHUKWU-EZIKE 
Published: March 2020

Objectives: The serum zinc and platelet statuses of sickle cell patients attending General Hospital, Owerri, Nigeria, were investigated.
Methods: Fifty confirmed sickle cell patients (hemoglobin [Hb]SS) age 10–30 years were selected. Fifty normal subjects (HbAA) age 10–30 years were used as control. The zinc and platelets were determined using standard methods.
Results: The levels of serum zinc, selenium, and platelet were significantly decreased in sickle cell anemia (p<0.05) when compared with the control.
Conclusion: The result suggests that supplementation of sickle cell patients with food and drug-containing zinc might be helpful, particularly in wound healing, as zinc positively correlates with platelet counts. These low zinc, selenium, and platelets could represent a risk for sickle cell anemia.
O PÚBLICO-ALVO DA EDUCAÇÃO ESPECIAL NA EDUCAÇÃO INFANTIL DE NITERÓI: ENTRE DIAGNÓSTICOS E DIREITOS. THE TARGET AUDIENCE OF SPECIAL EDUCATION IN EARLY CHILDHOOD EDUCATION FROM NITERÓI: BETWEEN DIAGNOSTICS AND RIGHTS
Authors: Dos Santos Fernanda Viannay Siqueira , Dos Santos Rosane Barreto Ramos , De Queiroz Paulo Pires 
Published: March 2020

Considerando a especificidade da educação especial na perspectiva inclusiva e a dificuldade na execução de políticas públicas favoráveis ao processo de inclusão dos alunos com deficiência, objetivamos, neste trabalho, investigar os critérios de identificação e de inclusão dos alunos, público-alvo da educação especial da Rede Municipal de Niterói. Para isso, examinamos os documentos oficiais da política de educação inclusiva do município. Na tentativa de contribuir para desvelar caminhos que atendam às expectativas direcionadas para um atendimento de qualidade, este trabalho pontua os avanços e retrocessos da educação inclusiva na Rede Municipal de Niterói, destacando a necessidade de articulação entre os sistemas de apoio, responsáveis pela promoção da educação inclusiva na Rede.
MASCULINIDADES NEGRAS EM MOVIMENTO – O CINEMA NEGRO COMO PRÁTICA DECOLONIAL NA EDUCAÇÃO BLACK MASCULINITY IN MOVEMENT –THE BLACK CINEMA AS A DECOLONIAL PRACTICE IN EDUCATION
Authors: Correa Marco Aurélio Da Conceição 
Published: March 2020

Este ensaio tem a proposta de dar continuidade na crescente discussão sobre as masculinidades negras, reconhecendo que estas são subjugadas como inferiores, devido as raízes coloniais racistas que criam relações assimétricas de poder, cria-se uma masculinidade hegemônica patriarcal do homem branco, hétero e cristão. Esta violência colonial aprisiona até os dias de hoje as subjetividades e as representações do homem negro. O cinema como artefato reprodutor da realidade acaba a dar sequência a estes históricos estereótipos. Porém, existe na atualidade uma emergente criação cinematográfica que busca outras representações estéticas para os corpos e mentes negras. A partir destes filmes pensamos em possibilidades pedagógicas que descolonizem as mentes e ressignifiquem as masculinidades negras. This text has the proposal to continue the growing discussion about black masculinities, recognizing that those are subjugated as inferior because of the racist colonial roots that create asymmetrical relations of power creating the patriarchal hegemonic masculinity of the white, straight and Christian man. This colonial violence imprisons until the present day the subjectivities and representations of the black man. Cinema as a reproductive artifact of reality ends up following these historical stereotypes. However, nowadays there is an emerging cinematic creation that seeks other aesthetic representations for black bodies and minds. From these films we think of pedagogical possibilities that decolonize the minds and resignify the black masculinities.
A UNIVERSALIZAÇÃO DAS BIBLIOTECAS ESCOLARES MUNICIPAIS DO ESTADO DO RIO DE JANEIRO E OS PROFISSIONAIS QUE NELAS ATUAM THE UNIVERSALIZATION OF THE MUNICIPAL SCHOOL LIBRARIES OF THE STATE OF RIO DE JANEIRO AND THE PROFESSIONALS THAT ACT IN THEM
Authors: Corsino Patrícia , Vilela Rafaela , Travassos Sônia 
Published: March 2020

Este artigo discute a universalização das bibliotecas escolares de municípios do Estado do Rio de Janeiro, tendo em vista a Lei 12.244 que determina esta universalização até 2020, e apresenta reflexões sobre o profissional que nelas atuam e suas funções. Trata-se da análise de parte das respostas de um questionário distribuídos às 92 secretarias municipais de educação do estado que obteve 67% de retorno. A pesquisaevidencia que os municípios ainda não universalizaram as bibliotecas nas escolas, especialmente na Educação Infantil, e que pouco mais da metade já colocou este tema em pauta. Mostra também poucas reflexões sobre o profissional que atua nas bibliotecas escolares. No entanto, a maioria das respostas consideram que das funções atribuídas a ele incluem a organização do espaço, o tratamento do acervo e ações mediadoras da leitura. This article discusses the universalization of the school libraries of municipalities of the state of Rio de Janeiro, in view of law 12.244 that determines this universalization until2020, and presents reflections on the professionals who work in them and their functions. It is the analysis of part of the answers of a questionnaire distributed to the92 municipal secretaries of education of the state that obtained 67% of return. The research shows that municipalities have not yet universalized libraries in schools,especially in early childhood education, and that little more than half has already put this topic in the agenda. It also shows few reflections about the professional who works in school libraries. However, most of the answers consider that the functions assigned to him include the organization of space, the treatment of the collection and mediating actions of reading.