bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of intramyocardial haemorrhage on structural and functional echocardiographic parameters of myocardium after ST-segment elevation myocardial infarction with
Authors: Alekseeva Ya. V. , Vyshlov E. V. , Mochula O. V. , Ussov V. Yu. , Ryabov V. V. 
Published: December 2020

Aim. To analyze the effect of intramyocardial haemorrhage (IMH) on the structural and functional echocardiographic parameters of myocardium in patients with primary ST-segment elevation myocardial infarction (STEMI).Material and methods. The study included 60 patients with primary STEMI reperfused within 12 hours after symptom onset. On the second day after the event, all subjects underwent gadolinium-enhanced cardiac magnetic resonance imaging (MRI). IMH was visualized as T2-weighted hypointense areas. Subsequently, all patients underwent the standard echocardiography on the 7th day after MI.Results. IMH was revealed in 31 patients (51,6%). In 22 patients (70,9%), IMH was accompanied by microvascular obstruction (MVO). In the remaining 9 patients (29%), an isolated IMH phenomenon was visualized. Lower values of left ventricular ejection fraction (LVEF) and LV volume parameters were associated with a combination of MVO and IMH. At the same time, the indices of volumetric characteristics and LVEF in isolated IMH were the same as in the group without IMH and MVO. It was demonstrated that the IMH occupies 1% (1-3%) of the LV myocardium. Correlation analysis showed a moderate inverse correlation between the IMH area and LV contractile function: the larger the area, the lower the LVEF (R=-0,35; p=0,007).Conclusions. The analysis of the influence of different IMH phenotypes on the structural and functional echocardiographic parameters of myocardium in the short-term period after STEMI has shown that the combination of IMH with MVO and isolated IMH have different effects on LV contractile function. The combination of IMH with MVO is a predictor of a decrease in LVEF and increase of end-systolic volume (ESV), while an isolated IMH does not affect these parameters. Correlations between the IMH area and a decrease in LVEF, as well as an increase in ESV, have been demonstrated.
Decreased arterial compliance assessed by aortic pulse wave velocity is an important parameter for monitoring of blood pressure in patients with chronic inflammatory diseases
Authors: Yilmaz Ak H. , Ozsahin Y. , Baskurt Aladag N. , Gencoglu F. , Sahin Yildiz B. , Haberal I. , Koyuncu A. Ozan , Yildiz M. 
Published: December 2020

Aim. Patients with chronic inflammatory diseases (CID), such as rheumatoid arthritis (RA) and familial Mediterranean fever (FMF) are more likely to have higher risk of cardiac events. Pulse wave velocity (PWV) can be used to measure the aortic dis-tensibility and it is known as inversely related to the arterial compliance. Increased aortic stiffness which is assessed by PWV, is seem to be associated with arterial blood pressure. In this study, we investigated the arterial compliance by PWV in patients with CID including RA and FMF.Material and methods. We studied 25 patients with RA, 33 patients with FMF and 31 healthy subjects without a history of any cardiovascular risk factors such as hypertension, diabetes mellitus, hyperlipidaemia (89 subjects in total). We measured the arterial compliance by automatic carotid-femoral (aortic) PWV using Complior Colson (France) device. PWV (m/s) = distance (m)/transit time(s).Results. It is seen that, patients with CID have higher carotid-femoral (aortic) PWV (8,76±2,09 vs 8,07±0,94 m/s) compared to control groups (p=0,03). There were significant correlations between PWV and age, body-mass index, systolic blood pressure, diastolic blood pressure and mean blood pressure. (p<0,001, r=0,65; p<0,001, r=0,36; p<0,001, r=0,42; p<0,001, r=0,46; p<0,001, r=0,48, respectively).Conclusion. Arterial compliance, which is assessed by carotid-femoral (aortic) PWV, is decreased in patients with CID such as RA and FMF when it is compared to healthy control group.
Association of tumor necrosis factor-alpha and interleukin-10 levels with ultrasound characteristics of atherosclerotic plaques in patients with essential hypertension
Authors: Polupanov A. G. , Zalova T. B. , Geleskhanova Yu. N. , Sarybaev A. Sh. , Romanova T. A. , Dzhumagulova A. S. 
Published: December 2020

Aim. To study the association of ultrasound characteristics of carotid atherosclerotic plaques (ASPs) with the concentration of tumor necrosis factor-alpha (TNFα) and interleukin-10 (IL-10) in patients with essential hypertension.Material and methods. The study included 117 patients (men, 75; women, 42) with essential hypertension aged 40 to 75 years (mean age, 55,8±7,5 years). All patients underwent anthropometric measurements (height, weight, body mass index, waist circumference), assessment of blood pressure and heart rate, blood tests (levels of glucose, creatinine with the calculation of glomerular filtration rate using CKD-EPI equation, lipid profile), duplex ultrasound of the carotid arteries. Also, the blood concentration of TNFα and IL-10 by the enzyme-linked immunosorbent assay using CYTOKIN-STIMUL-BEST (Novosibirsk,Russia) kit was determined.Results. According to the results of carotid duplex ultrasound, 3 groups of patients were identified. Group 1 included 48 patients with homogeneous hyperechoic ASPs; group 2 — 56 patients with dominant hyperechoic ASPs (>50% of areas); group 3 — 13 patients with anechoic, unstable, low-density ASPs. TNFα concentration in group 3 patients, amounting to 10,51±2.23 pg/ml, was significantly higher than in patients of group 1 (7,26±0,64 pg/ml (p<0,001)) and group 2 (8,93±0,98 pg/ml (p<0,001)). Similar results were obtained for IL-10. The logistic regression showed that the TNFα concentration is an independent factor associated with unstable ASsP (relative risk, 2,72; 95% confidence interval 1,44-5,15 (p<0,02)). It was also revealed that TNFα >10 pg/ml increased the risk of ASP instability by ~8 times.Conclusion. An increase in TNFα >10 pg/ml with a high specificity (95%) was associated with vulnerable unstable carotid ASPs.
Effects of spironolactone and eplerenone on left ventricular diastolic function and neurohumoral factors in patients with heart failure
Authors: Nuritdinov N. A. , Kamilova U. K. 
Published: December 2020

Aim. To study the effects of spironolactone and eplerenone on left ventricular diastolic function and neurohumoral factors in patients with heart failure (HF).Material and methods. We examined 131 patients with coronary artery disease and NYHA class I-III HF. Patients were randomized into groups depending on HF class: class I (n=31), class II (n=51) and class III (n=49).Results. The study revealed that the clinical course of HF and LV diastolic dysfunction are associated with an increased level of neurohormones and are characterized by significantly high levels of aldosterone and norepinephrine in patients with a restrictiveLV diastolic dysfunction. A correlation was found between the level of neurohormones (aldosterone and norepinephrine) and heart remodeling parameters: an inverse correlation with an ejection fraction (r=-0,68, r=-0,61, respectively) and a direct correlation with LV end-diastolic volume (r=0,58, r=0,66, respectively). Long-term treatment with spironolactone and eplerenone had a positive effect, reducing the level of mentioned neurohormones. In patients with class II HF, both drugs had a positive effect on the level of aldosterone and norepinephrine, reducing them by 26,6% and 20,2% in the spironolactone group and by 28,4% and 24,6% in the eplerenone group, respectively. In patients with class III HF, the decrease in aldosterone level was more pronounced in those taking eplerenone than spironolactone: 32,1% vs 20,2%, respectively.Conclusion. In patients with HF, combination therapy with the inclusion of spironolactone significantly reduced the level of neurohormones mainly in patients with class II HF and, to a lesser extent, in those with class III HF. This suggests that combination therapy with spironolactone is less effective than with eplerenone in relation to neurohormones’ levels.
Phenotypes of early and favorable vascular aging in young people depending on the risk factors and presence of connective tissue dysplasia
Authors: Evseveva M. E. , Eremin M. V. , Rostovtseva M. V. , Sergeeva O. V. , Fursova E. N. , Rusidi V. A. , Galkova I. Yu. , Kudryavtseva V. D. 
Published: December 2020

Aim. To study the main risk factors and signs of connective tissue dysplasia (CTD) in young people according to quartile analysis of cardioankle vascular index (CAVI).Material and methods. The study involved 243 young people (men, 81; women, 162) aged 18-25 years. All subjects were divided into quartile groups depending on CAVI on both sides, or CAVI-R and CAVI-L, determined using the VaSera-1500 system (Fucuda Denshia,Japan). According to the latest guidelines, the 4th quartile of this distribution among persons of the same sex and age corresponds to early vascular aging (EVA) syndrome. The 1st quartile corresponds to favorable vascular aging. We analyzed the main RFs and CTD signs in each of the 4 CAVI quartiles. Data processing was carried out using the Statistica 10.0 software package (StatSoft Inc,USA).Results. The minimum and maximum CAVI in the sample were 3,2 and 7,9. The overwhelming majority of studied risk factors in both sexes were not associated with the stiffness. Only body mass and body mass index increasedwith a decrease in vascular stiffness and vice versa. The average number of external stigmas of dysembryogenesis in young people increased from the 1st to the 4th CAVI quartile, with significant differences in the extreme groups. Such CTD signs as a carpal tunnel syndrome and thumb sign also significantly differed between the 1st and 4th quartiles.Conclusion. The presented results can be used for prevention among young people to form more individualized programs taking into account a comprehensive assessment of vascular aging phenotype and the level of external stigmatization of each young person.
Adherence to therapy, lifestyle modification and medical support of cardiovascular patients
Authors: Bunova S. S. , Zhernakova N. I. , Skirdenko Yu. P. , Nikolaev N. A. 
Published: December 2020

Aim. To study the quantitative parameters of adherence to lifestyle modification, medical support, and therapy in patients with cardiovascular diseases (CVD).Material and methods. This cross-sectional study included 683 respondents: 168 patients with hypertension (HTN); 196 patients with stable angina; 141 patients with atrial fibrillation (AF); 178 patients with heart failure (HF). We used N. A. Nikolaev questionnaire for adherence assessment. For all adherence parameters, the level ≤75% was regarded as insufficient. The study was carried out in accordance with Good Clinical Practice and Declaration ofHelsinki. The study protocol was approved by the Ethics Committees of all participating clinical centers. All patients signed written informed consent.Results. Approximately 1/3 of respondents agreed to receive therapy. The adherence level was >75%. Patients with angina and AF were more likely to receive therapy. It turned out that that approximately 2/3 of patients were not ready for medical support. Patients with angina were less ready for medical support, while those with HTN and HF hadhigher values of adherence. Adherence to lifestyle modification was owest among analyzed parameters. Only 18,5% of hypertensive patients, 25,5% of patients with angina, 26,2% of AF patients and 23,1% of patients with HF were ready to change the lifestyle.Conclusion. The study revealed a significant number (~2/3) of CVD patients with insufficient adherence, which specifies the need to assess the effectiveness of therapy and course of the disease in conditions of low adherence and to develop individualized therapeutic strategies.
Sympathetic hyperactivity in patients with hypertension: pathogenesis and treatment. Part I
Authors: Safaryan A. S. , Sargsyan V. D. 
Published: December 2020

The article is devoted to the influence of sympathetic nervous system (SNS) on the cardiovascular system. Influence of SNS activity on the blood pressure level and the pathogenesis of hypertension development, as well as the effect of SNS on many biochemical and metabolic parameters playing a key role in the development of metabolic syndrome and hypertension are considered. Possible mechanisms of action of various methods that reduce the SNS activity, restore the function of autonomic nervous system and normalize the cardiovascular system and blood pressure are considered.
Endovascular myocardial revascularization in patients with multivessel coronary artery disease with chronic total occlusion and high surgical risk
Authors: Vasiliev D. K. , Rudenko B. A. , Shanoyan A. S. , Shukurov F. B. , Feshchenko D. A. 
Published: December 2020

The main reason for incomplete myocardial revascularization is the presence of chronic coronary total occlusion (CTO), which is detected in every fourth patient during coronary angiography. At the same time, a generally accepted approach to the treatment of CTO has not yet been developed.Aim. To assess the rationale of complete myocardial revascularization in patients with multivessel coronary artery disease (CAD) with chronic total occlusion and high surgical risk.Material and methods. This retrospective, open-label, non-randomized clinical trial was carried out included 180 patients multivessel CAD and CTO. The patients underwent endovascular surgery for complete myocardial revascularization. Depending on the success of surgery, the patients were divided into groups of complete and incomplete myocardial revascularization. Endpoints were death, acute coronary syndrome, re-revascularization after 1-year follow-up. Left ventricular (LV) contractility and clinical status of patients in the study groups after 1 year of observation was assessed.Results. The median follow-up was 12,1 months. The successful rate of revascularization was 79,4%. The incidence of main composite endpoint in the group of complete myocardial revascularization was 5,59%, while in the group of incomplete revascularizations — 21,6% (p=0,005).Conclusion. The study showed that low incidence of intraoperative complications and a high successful rate of revascularization are characteristic of complete myocardial revascularization in patients at high surgical risk with multivessel CAD and CTO. Complete myocardial revascularization leads to a significant decrease in the incidence of major coronary events.
COVID-19 biobank: features of the cytokine profile
Authors: Sushentseva N. N. , Popov O. S. , Apalko S. V. , Anisenkova A. Yu. , Azarenko S. V. , Smantserev K. V. , Khobotnikov D. N. , Gladysheva T. V. , Minina E. V. , Strelyukhina S. V. , Urazov S. P. , Pavlovich D. , Fridman S. R. , Shcherbak S. G. 
Published: December 2020

Aim. Using a collection of samples from the biobank ofCityHospital № 40 ofSt. Petersburg, to study the cytokine profile in patients with coronavirus disease 2019 (COVID-19) and sepsis, in comparison with patients with abdominal inflammation and septicemia.Material and methods. The study included serum samples from 181 patients with sepsis and COVID-19 (127 patients with a diagnosis confirmed by polymerase chain reaction (PCR); 54 patients with a negative PCR test, but with a characteristic computed tomographic lung performance) and 47 patients with abdominal sepsis. The content of cytokines was determined using a multiplex immunofluorescence analysis based on the Luminex xMAP technology using the HCYTOMAG60K panel — a soluble CD40 ligand (sCD40L), interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNFα), vascular endothelial growth factor (VEGF). Other laboratory parameters (C-reactive protein (CRP), ferritin, procalcitonin) were taken from patient records. Normality of distribution was assessed by the Shapiro-Wilk test. To compare groups, the Mann-Whitney test for independent samples, Wilcoxon test for dependent samples, and the Kruskal-Wallis test with Bonferroni correction for multiple comparisons were used.Results. In patients with sepsis and COVID-19 infection, no differences in the concentrations of cytokines, ferritin and CRP were found between the groups with detected and not detected virus by PCR test. Based on this, this group was considered homogeneous when studying the cytokine profile. It was shown that in patients with sepsis and COVID-19, significantly higher levels of sCD40L (p<0,0001) and VEGF (p=0,037) and relatively low levels of CRP (p<0,0001), IL-6 (p<0,0001), IL-8 (p<0,0001), TNFα (p<0,00058).Conclusion. These results indicate that sepsis in patients with COVID-19 courses with less elevation in inflammatory cytokine than in abdominal sepsis. At the same time, a critically high level of sCD40L indicates the significant endothelial damage.
Cell biobank as a necessary infrastructure for the development and implementation of mesenchymal stem cell-based therapy in the treatment of anthracycline-induced cardiotoxicity. Literature review and own data
Authors: Grivtsova L. Yu. , Popovkina O. E. , Dukhova N. N. , Politiko O. A. , Yuzhakov V. V. , Lepekhina L. A. , Kalsina S. Sh. , Ivanov S. A. , Kaprin A. D. 
Published: December 2020

Cardiovascular diseases, along with cancer, are the leading causes of death worldwide. Although modern pharmacological treatment of various cardiomyopathies can slow the development of myocardial dysfunction, they have limited effectiveness in patients with end-stage disease. Many researchers believe that heart transplantation is the only radical treatment in this case. However, the lack of donors and the high operation cost require careful selection of surgical candidates. With the introduction of molecular and cell biology into medical practice, today, stem cell therapy can become an alternative method of nonsurgical restoration of myocardial functions. The most studied and attractive is the use of mesenchymal stem cells (MSCs). MSCs differ from hematopoietic stem cells used as support for hematopoiesis in high-dose chemotherapy by the following features: pronounced trophic effect, immune tolerance, the ability to suppress alloreactivity and autoimmune disorders. An important stage in the implementation of cell therapy is the creation of a cell biobank of MSCs. In A.F.Tsyb Medical Radiological Research Center, this work has been carried out since1984. Asignificant number of experimental studies have been carried out, confirming the possibility of clinical implementation of this approach. A method for obtaining stable cultures of MSCs and cardiomyoblasts from bone marrow cells was developed and approvals were obtained. Experimental studies of cell therapy are also being conducted to overcome anthracycline-induced cardiotoxicity in cancer patients.This article is devoted to practical application of MSC-based therapy, in particular, in cancer patients with cardiotoxicity, as well as to the issues of creating a cell biobank for treatment with MSCs.
Validación del instrumento compromiso organizacional “CO” en docentes de diversas instituciones UGEL 006, Lima, 2020
Authors: Neyra Vilcarromero Maricruz , Aliaga Jimenez Bryan Kevin , Burgos Chavez Victor Santos , Álvarez Manrique Víctor Daniel 
Published: December 2020

El objetivo de este trabajo de investigación es evaluar la consistencia interna y confiabilidad del instrumento CO de compromiso organizacional mediante un análisis exploratorio. El instrumento creado por Meyer y Allen (1993), traducido al español por Arciniega & González (2012), mide las dimensiones compromiso afectivo, compromiso de continuidad y compromiso normativo mediante 18 reactivos. El análisis previo de consistencia interna se encontró un Alpha de Cronbach para el total de instrumento a=0.910 y 0.764, 0.790, 0.756 para cada una de las dimensiones. Para verificar la homogeneidad de las variables (reactivos), previamente se realizaron las estimaciones mediante KMO, obteniendo un índice de Káiser Meyer Olkin aceptable de 0.916 y un Chi cuadrado de 670,524 con 153 grados de libertad y nivel de significancia =0.000 (p <.001) mediante la prueba de esfericidad de Bartlett, como requisito para la extracción de factores mediante componente rotados, obteniéndose para el primer factor cargas entre 0.674 y 0.685, para el segundo factor, cargas entre 0.834 y 0.557, para el tercer factor, cargas entre 0.724 y 0.669, demostrando evidencia de una alta correlación, porque son mayores a 0.4, cumpliendo el objetivo de ver si se agrupan empíricamente, tal como, teóricamente se había predicho, Sin embargo, el reactivo CONT 7 (0.516, 0.446) y NOR (0.370, 0.448) no obtuvo carga en su dimensión y los reactivos AFE 1 (0.685), AFE 2 (0.674), AFE 4 (0.587), AFE 6 (0.544), CONT 8 (0.347), CONT 10 (0.557), CONT 11 (0.553), CONT 12 (0.531), NOR 16 (0.616), NOR 17 (0.518) y NOR 18 (0.480) obtuvieron cargas adicionales en otros factores, pudiendo ser eliminados, se decidió mantenerlos en su factor teórico, esperando un análisis confirmatorio.
2013 Okul Öncesi Eğitim Programının Karakter Eğitimi Açısından Değerlendirilmesi
Authors: KOCALAR Evrim , BAY Erdal 
Published: December 2020

Karakter eğitimi, karakterin yapı taşı olup, bireyin karakterini inşa eden eğitim olarak tanımlanmaktadır. Okul öncesi dönem çocuğun karakterinin büyük bir kısmının şekillendiği, gelecekte nasıl bir kişi olacağının temellerinin atıldığı kritik bir dönemdir. Bu dönemde çocuğa verilecek olan karakter eğitimi ve eğitimin niteliği büyük önem arz etmektedir.
Bu çalışmanın amacı, 2013 okul öncesi eğitim programını karakter eğitimi açısından analiz etmektir. Araştırmada döküman analizi yöntemi; veri toplama aracı olarak “2013 Okul Öncesi Eğitim Programı ile 2013 Okul Öncesi Eğitim Programları Etkinlik Kitabı ve 2018 Okul Öncesi Etkinlik Kitabı” kullanılmıştır. Verilerin analizi sırasında önce kodlar belirlenmiş daha sonra tema ve kategoriler çıkarılmıştır.
Araştırma sonuçlarına göre; programda en fazla dikkatli, yaratıcı, yetenekli ve bağımsız özelliklerine yer verildiği saptanmıştır. 2013 Okul Öncesi Eğitim Programı ile 2013 ve 2018 Etkinlik Kitaplarının karakter eğitimi açısından birbirleri ile uyumlarının olduğu görülmüştür. Çünkü programda en çok yer alan karakteristik özelliklerin, etkinlik kitaplarındaki etkinliklerde de yoğun bir şekilde bulunduğu görülmektedir.
19. YÜZYILDA URFA SANCAĞI İDARECİLERİ HAKKINDAKİ ŞİKÂYETLER
Authors: Yılmaz Hacer 
Published: December 2020

Sosyal, ekonomik ve idari tarih açısından Türk yenileşme tarihinin miladı olarak kabul edilen Tanzimat devrinde, hemen her alanda görülen yeniden yapılanma idari alanda da kendini göstermektedir. Yapılan reformlarla birlikte, eyaletler vilayet, sancaklar ise liva adını alarak, taşra teşkilatı yeniden yapılandırılmıştır. Devletin taşra teşkilatını yeni bir yapılandırmaya tabi tutmasının amacı, her türlü geliri merkezi hazine adına toplatmak, taşrada asayişi sağlamak ve merkezileşmektir. Çünkü 19. yüzyılda Osmanlı Devleti, vergilerin tespitini, toplanmasını ve yerel yönetimleri kontrol altında tutamıyordu. Tanzimat ile birlikte, idarecilerin keyfi yönetimleri altında ezilen halkın refah ve huzurunu sağlamak amaçlanmıştır. Ancak pratikte bu pek de mümkün olmamıştır. Çünkü vasıflı yönetici yetiştirecek bir kurum bulunmadığı için, valiler daha evvel valilik yapmış kişiler arasından seçilmiştir. 19. yüzyılda Osmanlı Devleti’nde yaşanan problemlerin kısa bir analiziyle başlayacak olan çalışmamızda, Urfa sancağındaki yerel idarecilerin haksız ve kötü yönetimleri, arşiv belgeleri ışığında izah edilecektir. Çalışmamızın sonunda ise kısa bir değerlendirme yapılacaktır.