bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrategias didácticas para el aprendizaje de los contenidos de trigonometría empleando las TICs
Authors: Sánchez Rosal Andrés Alexander 
Published: May 2020

La investigación se enmarca dentro de la línea apoyo tecnológico al docente. Su propósito fundamental fue proponer estrategias didácticas empleando las TICs dirigida a los profesores del área de trigonometría de Educación Media. El estudio se orientó en los principios del aprendizaje significativo y de las estrategias didácticas. En virtud de los resultados obtenidos y el contraste de la información, se evidenció que la estrategia didáctica utilizada por la mayoría de los profesores es la exposición. Por lo tanto, se recomienda el uso de las estrategias didácticas apoyadas con las TICs, lo que justifica la propuesta dirigida a las instituciones participantes en la investigación. AbstractThe investigation is framed along the line of Technological help for the teacher. Its main aim is to suggest educational strategies using the TICs and is aimed at the trigonometry teachers Medium Education.. The investigation, from the learning process perspective, was pointed towards the significant learning and the educational strategy principles.. In view of the results obtained and the contrast in the information, it is evident that the educational strategy mostly used by the teachers is the exposition. Because of this, the students follow the traditional educational schemes: observe and listen to the teacher; just take notes. The instructional methods employed in the classes are the board and the theory-practical guides.
Algunas claves en una experiencia de personalización en la formación abierta
Authors: Fandos Igado Manuel , Cano Escoriaza Jacobo 
Published: May 2020

Este artículo parte de las oportunidades y dificultades que se presentan en el seno de las empresas de formación (en modalidad no presencial) al tener que armonizar la voluntad de ofrecer una formación individualizada y la necesidad de una estandarización de los productos y servicios que permitan la supervivencia de las mismas. En el desarrollo de sus reflexiones reflejan el modelo que ha implementado el grupo Master.D para conciliar estas dificultades y cómo se puede articular esta conciliación con la necesaria calidad del producto y del servicio que se brinda al alumnado -clientes en el caso de las empresas-. Se aporta un análisis sobre el rol de los docentes en este contexto formativo y la conveniencia de un riguroso trabajo colaborativo entre este tipo de empresas y el ámbito universitario y describe el proceso de tutorización y seguimiento individualizado en el proceso formativo del alumnado. Una reflexión sobre el rol de los docentes en este contexto y la conveniencia de un riguroso trabajo conjunto entre este tipo de empresas y la reflexión teórico académica del mundo universitario, la investigación en el tratamiento de las nuevas posibilidades que ofrece el desarrollo de las nuevas tecnologías, así como la focalización en el acompañamiento del aprendiz son algunos de los indicadores más destacados que se presentan.Some key factors in the experience of the personalisation of open learning Abstract This article breaks down the opportunities and difficulties that are presented in the backbone of companies dedicated to education (not based on attendance) to have to harmonise the desire to offer personalised education and the need to standardise the products and services that permit their existence. In the development of these reflections the model that the Master.D Group has implemented to reconcile these difficulties is presented, and how this reconciliation can be articulated with the necessary product and service quality that is offered to the student -customers in the case of the company-. An analysis of the role of the teaching staff is provided in this formative context and the convenience of a collaborative rigorous job within this type of company and in the university sphere, and describes the process of tutorisation and personalised monitoring in the student’s learning process. A reflection of the role of the teaching staff in this context and the convenience of a joint rigorous job within this type of company, the academic theory reflected in the university sphere, the investigation into the treatment of new possibilities that the development of new technologies offer, as well as the focus on the accompaniment of learning are some of the most prominent indicators that are presented.
Análisis de las intervenciones de apertura de foros de formación online desde una perspectiva discursivo multimedial y didáctico discursiva
Authors: Alvarez Guadalupe , Morán Lourdes 
Published: May 2020

No cualquier uso de las tecnologías de la información y la comunicación garantiza la construcción del conocimiento. Se vuelve entonces importante estudiar las modalidades comunicativas en los foros. En relación con ello, y considerando que la emisión iniciadora suele funcionar como guía de las emisiones subsiguientes, se propone elaborar una caracterización de la intervención de apertura de los foros. Para ello, se analizan dichas intervenciones desde una perspectiva discusivo multimedial y didáctico discursiva.Analysis of open online education forum from a discursive multimodal and didactic discursive perspectives AbstractNot all uses of information and communication technologies (ICT) guarantee the knowledge construction. For that reason, the study of forum communicative modalities becomes important. With regard to this, and considering that the open intervention is usually a guide for the following interventions, the aim of this article is to elaborate a characterization of the forum open interventions. In this sense, these interventions are analyzed from multimodal discursive and didactic discursive perspective.
Análisis socioeducativo del blogueo como actividad alfabetizadora y colaborativa
Authors: Santoveña Casal Sonia Mª 
Published: May 2020

El objetivo de la investigación es conocer la incidencia del uso de los blogs en la mejora de las relaciones sociales y de la formación académico-profesional de los usuarios y propietarios de blogs. La muestra está formada por 179 usuarios y/o propietarios de blogs. Es un estudio basado en un diseño mixto y el instrumento de recogida de información ha sido una entrevista semiestructurada. Desde el paradigma de los nuevos alfabetismos, es posible estudiar el blogueo para llegar a comprender su utilidad en el ámbito educativo.Socio-educational analysis of blogging as literacy and collaborative activityAbstractThe purpose of this research is to know the influence of the use of blogs on the improvement of social relationships and academic and professional training of both users and owners of blogs. The sample is formed by 179 users and owners of blogs. It is a study based in a mixed design and the research instrument used is a semistructured interview. Since we are following the approach of the new literacies, it is possible to study blogging to get to know its use on the educational system.
Objeto de aprendizaje abierto orientado a desarrollar la competencia en el manejo del inglés
Authors: Tiscareño Ramírez Ana Bertha , López Ibarra Alejandro , Ramírez Montoya María Soledad 
Published: May 2020

En este estudio se validó, a través de diferentes expertos, que los criterios de calidad requeridos para producir un Objeto de Aprendizaje Abierto orientado al desarrollo de la competencia para manejar el inglés en docentes son: contenidos relevantes, objetivos claros y alcanzables, motivación generada por los desafíos intelectuales y elementos multimedia, evaluaciones significativas, navegación amigable, un uso y acceso sencillo, un objeto reusable con formato atractivo y una redacción clara.AbstractThe objective of this research work was to validate the quality criteria needed to produce a Learning Object (LO). The object is intended to develop language competencies and to contribute to the professional development of the English language teacher. Experts in different disciplines interacted with the object and the quality criteria are: meaningful content, clear attainable objectives, motivation through intellectual challenges and multimedia elements, meaningful evaluation items, usability, accessibility, reusability, attractive format and clear writing.
Adaptación de los estudios de magisterio al EEES: las TIC en los nuevos planes de estudio
Authors: Herrada Valverde Rosario Isabel , Herrada Valverde Gabriel 
Published: May 2020

Este artículo analiza el proceso de adaptación de los antiguos títulos de Maestro a los nuevos Grados adaptados al Espacio Europeo de Educación Superior en las universidades públicas españolas y, en particular, la presencia de asignaturas relacionadas con las Tecnologías de la Información y la Comunicación. El análisis de los datos recopilados muestra como este proceso ha dado lugar a una dispersión de la presencia de estas asignaturas dependiendo de cada universidad y especialidad.Adaptation of teacher training degrees to the EHEA: ICT in the new study plansAbstractThis paper analyzes the adaptation process of the old preservice teacher degrees to the new ones adapted to the European Higher Education Area, in particular, about the presence of subjects related with Information and Communication Technologies. The analysis of the collected data shows that this process has involved dispersion in the presence of these subjects according to the university and speciality.
Formación del profesorado en TIC, en la zona de los montes orientales de Granada
Authors: Ferrero Guevara Sergio , Martínez Serrano María Del Carmen 
Published: May 2020

El objetivo prioritario del estudio que aquí se expone, se centra en concretar las necesidades de formación del profesorado de Educación Primaria en la zona de los Montes Orientales de Granada, en relación a las TICs, como apoyo a su labor educativa. El estudio tiene una finalidad descriptiva y utiliza el estudio de encuesta, desarrollado en el curso académico 2010-2011, cuyos datos se analizaron cuantitativamente. El estudio, nos aporta información sobre tres aspectos esenciales: la formación del profesorado en Nuevas Tecnologías; la incorporación de éstas en el currículum así como la contribución de los CEP en este cambio metodológico.ITC’s teacher training in the sierra of Granada (western area)AbstractThe main subject of analysis here presented is focused on being specific about Primary School Teacher Training Needs concerning ICTs as additional help to their teaching work in the Eastern part of Granada Mountains. This study, with a descriptive aim, leans on a survey carried out during the school year 2010-11 whose data were analyzed quantitatively. This study provides information on three vital aspects: Teacher Training in New Technologies; the implementation of these in the curriculum and the contribution of CEPs (Teacher Training and Support Centres) to this methodological change.
Blended-learning. Desafío y oportunidad para la educación actual.
Authors: Morán Lourdes 
Published: May 2020

El desarrollo de las TIC y las nuevas formas de acceder al conocimiento, plantean la necesidad de pensar en nuevas formas de diseñar propuestas formativas. El cambio y la transformación de la educación deben basarse en un nuevo tipo de currículo y configuraciones didácticas superadoras. En este escenario, el B-Learning se configura como alternativa posible para una formación que trasciende los espacios del aula y se traslada a todas las esferas de la vida. En este trabajo se analizan las características de esta modalidad y se establecen criterios que permiten configurar propuestas que integran la formación presencial con la formación online. Blended-learning. Challenge and opportunity for the current education.AbstractThe development of the TIC and the new ways of acceding to the knowledge, raise the need to think about new ways of designing formative offers. The change and the transformation of the education must be based on a new type of curriculum and didactic configurations. In this scene, the B-Learning is formed as possible alternative for a formation that comes out the spaces of the classroom and moves to all the spheres of the life. In this work there are analyzed the characteristics of this modality and there are established criteria that allow to form offers that integrate the formation presencial with the formation online.
Impacto de las tecnologías de la información y la comunicación en la elección de universidad: el caso de Internet y las redes sociales
Authors: Fondevila Gascón Joan Francesc , Carreras Alcalde Marta , Del Olmo Arriaga Josep Lluís 
Published: May 2020

Internet y las redes sociales comienzan a condicionar la obtención de información por parte de los estudiantes a la hora de elegir Universidad. Mediante una encuesta a una muestra representativa de alumnos de la Universitat Abat Oliba CEU (UAO), analizamos el peso de Internet y las redes sociales (que se revela significativo) comparativamente con otras fuentes de información. Ello ayuda a establecer mejores estrategias de comunicación y de marketing por parte de las universidades.Impact of the information and communication de las technologies in the election of university: the case of the internet and the social networksAbstractInternet and social networks begin to condition the obtaining of information by students when they choose a university. By surveying a representative sample of students from the University Abat Oliba CEU (UAO), we analyze the weight of the Internet and social networks (which is significant) compared with other sources of information. This helps to ensure better communication and marketing by universities.
Effect of natural disinfectant (Moringa oleifera) and a chemical disinfectant (calcium hypochlorite) on nematode eggs: bioefficiency and impact of physico-chemical variables
Authors: Fotseu Kouam Arnold Landry , Ajeagah Gideon Aghaindum 
Published: May 2020

Abstract
The aim of this study is to determine the effectiveness of disinfectant on the viability of eggs from three nematode species (Ascaris, Trichuris, Ankylostoma). It was conducted in a microcosm from June 2018 to June 2019. The wastewater scan was sampled using 5 L sterile containers, the sample was arranged in four replicas, three tests and one control. The test samples received three disinfectants (Moringa, calcium hypochlorite and Moringa associated with calcium hypochlorite) at varying concentrations. The physical and chemical parameters were measured before and after the application of each disinfectant. The samples were then observed under an optical microscope. The viability of the eggs was determined by incubating the Petri dish samples at 30 °C for 30 days. The analyses show that some physicochemical parameters can significantly influence the efficacy of disinfectant on the eggs. The calcium hypochlorite associated with Moringa at 0.6 g/L showed greater efficacy on reducing viability and inactivation of eggs with 100% efficacy yield rates on Ankylostoma and Trichuris trichiuria and 97% on Ascaris lumbricoides eggs; this efficacy is significantly different from that observed on samples treated with Moringa and simple calcium hypochlorite. Of the three parasites tested, A. lumbricoides showed greater resistance to the disinfectant.
Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy
Authors: Girgis Germeen N.S. 
Published: May 2020

Purpose:
The work was performed to investigate the feasibility of preparing ocular inserts
loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system.

Methods:
First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared
and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with
Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated
physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected
formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with
free drug-loaded ocuserts.

Results:
The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized
with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and
62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between
drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to
0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC
showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability,
ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant
lowering in PMN count after 3h.

Conclusion:
These findings proposed a possibly simple, new and affordable price technique to prepare
promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory
efficacy.
Synthesis and Characterization of New Zinc Phthalocyanine - Dodecenyl Succinic Anhydride Benzoic Groups
Authors: Al-Bahrani Hussein Ali , Kareem Mohanad Mousa , Kadhum Abdul Amir , Alrazzak Nour A. 
Published: May 2020

Background:
The phthalocyanines a series of compounds involves four iso-indole units linked by
aza nitrogen atoms bonded with metal atoms that are normally located in the center a phthalocyanines ring.
Some of the central metal-phthalocyanines can be excited by ultraviolet light and emit a fluorescence in far-red
region.

Objective:
To synthesize a derivative of phthalocyanines namely 4,4',4' '-tri-(dodecenyl succinic anhydride)-
4' ' '-(5-amino salicylic acid) zinc phthalocyanine with a zinc central metal.

Materials and Methods:
The reaction of 4- nitro Phthalonitrile and 4- amino Phthalonitrile with ZnCl2 in the
presence of dimethyl amino ethanol afforded 4,4',4' '-triamino-4' ' '-nitro zinc phthalocyanine. This product
reacted with 5-amino salicylic acid to yield tetra-(5-amino salicylic acid) zinc phthalocyanine. A dodecenyl
succinic anhydride was added on the amine group of benzoic rings to afford 4,4',4' '-tri-(dodecenyl succinic
anhydride)-4' ' '-(5-amino salicylic acid) zinc phthalocyanine(I), the target compound.

Results and Discussion:
Compound I is successfully synthesized with a yield of 72% from tetra-(5-amino
salicylic acid) zinc phthalocyanine with dodecenyl succinic anhydride.

Conclusion:
The newly synthesized molecule of 4,4',4' '-tri-(dodecenyl succinic anhydride)-4' ' '-(5-amino
salicylic acid) zinc phthalocyanine (I), tetra-(5-amino salicylic acid) zinc phthalocyanine(E) and 4,4',4' '-
triamino-4' ' '-nitro zinc phthalocyanine (S). The reaction of 4- nitro Phthalonitrile and 4- amino and the
structure of compound I is confirmed and its formation was proven.
Design, Synthesis and Antifungal Activity of Novel 1-(Adamantan-1-yl) ethanone Oxime Esters
Authors: Liu Si , Niu Li-Zhi , Shi Yan-Hua , Wan Fu-Xian , Jiang Lin 
Published: May 2020

Background:
Oxime compounds, including oxime ethers and oxime esters, possess
various biological activities. Many oxime ethers have been widely used in the fields of pesticides and
medicines. However, oxime ethers are rarely used in the field of pesticides.

Methods:
We chose the excellent fungicide pyrifenox as the lead compound, integrated pyridinyl,
adamantyl and benzoyl moieties into one molecule, while also designed and synthesized ten 1-
(adamantan-1-yl)ethanone oxime esters containing pyridinyl moiety. Moreover, we also evaluated
their preliminary antifungal activities against S. sclerotiorum and B. cinerea.

Results:
The target compounds were characterized by NMR, IR and HRMS. The preliminary bioactivity
test showed that they exhibited some antifungal activity to S. sclerotiorum and B. cinerea, and
EC50 values were in the range of 14.16-32.97 and 27.60-52.82 μg/mL, respectively.

Conclusion:
Some target compounds such as 3d, 3e, 3h and 3i, exhibited moderate activities against
S. sclerotiorum, with EC50 values of 14.16-18.18 μg/mL.
Quantitation of Conjugation-related Residual Solvents in Antibody Drug Conjugates using Headspace Gas Chromatography
Authors: Zuniga Ruth V. , Kay Jacob , Gruenhagen Jason , Medley Colin D. 
Published: May 2020

Background:
Antibody Drug Conjugates (ADCs) are complex hybrid molecules comprised
of a monoclonal antibody (mAb) connected to a small molecule drug through a linker. The key step in
the production of ADCs is bringing together the protein in an aqueous buffer with a hydrophobic small
molecule in order to achieve conjugation of the molecules. This step involves dissolving the small
molecule portion of the compound in an aqueous miscible organic solvent. These solvents and unconjugated
small molecules are ideally cleared by downstream processing in order to achieve the desired
product quality. As part of the control system to ensure product quality, the determination of residual
solvents in pharmaceuticals is of significant importance in order to protect patient safety and ensure an
efficacious drug.

Objective:
Headspace gas chromatography (HS-GC) is the most widely used tool for quantification of
residual solvents for small molecule active pharmaceutical ingredients (APIs) but is not widely used
for the analysis of protein-containing samples. In this study, the detection of residual solvents in headspace
injections was explored using various conditions in order to detect commonly used conjugation
solvents including N,N-dimethylacetamide (DMA), N,N-dimethylformamide (DMF), dimethyl sulfoxide
(DMSO), Ethylene Glycol (EG), and Propylene Glycol (PG) in an ADC drug product sample.

Methods:
Various organic solvents were explored to enhance the response observed with complex protein
and residual solvent matrixes. As EG and PG do not partition into the headspace efficiently in the
ADC drug product samples that contain large amounts of water, ionic liquids and other ionic compounds
were screened with the ADC samples to see if they could improve the partitioning of the key
solvents EG and PG.

Results:
Following headspace and chromatographic optimization, we have developed an approach for
the detection and quantification of several conjugation reaction solvents in ADC samples.

Conclusion:
This new approach is an HS-GC method that simplifies Gas Chromatography (GC) analysis
and sample preparation and can be readily implemented in quality control testing for bioconjugated products.