bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mustajärvi orogenic gold occurrence, Central Lapland Greenstone Belt, Finland: a telluride-dominant mineral system
Authors: Mueller Matthias , Peltonen Petri , Eilu Pasi , Goldfarb Richard , Hanski Eero 
Published: June 2020

AbstractThe Mustajärvi gold occurrence lies in the southern part of the Paleoproterozoic Central Lapland Greenstone Belt, in proximity to the first-order transcrustal Venejoki thrust fault system. The gold occurrence is structurally controlled by the second-order Mustajärvi shear zone, which is located at the contact between siliciclastic metasedimentary and mafic to ultramafic metavolcanic rocks. The main mineralization comprises a set of parallel veins and sulfidized rocks that are slightly oblique to the shear zone and are hosted by third-order structures likely representing Riedel R-type shears. The gold-mineralized rock at Mustajärvi is associated with pyrite that is present in 0.15- to 1-m-wide quartz-pyrite-tourmaline veins and in zones of massive pyrite in the host rocks with thicknesses ranging from 1.15 to 2 m. In unweathered rock, hypogene gold is hosted by Au- and Au-Bi-telluride micro-inclusions in pyrite, whereas strong weathering at near surface levels has caused a remobilization of gold, resulting in free gold deposited mainly in the cracks of oxidized pyrite. The geochemistry of both mineralization styles is typical of orogenic gold systems with strong enrichments comprising Au, B, Bi, CO2, Te, and Se; and less consistent anomalous amounts of Ag, As, Sb, and W. Unusual for orogenic gold deposits is the strong enrichment of Ni and Co, which leads to the classification of Mustajärvi as orogenic gold occurrence with atypical metal association.
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals
Authors: van der Stel Wanda , Carta Giada , Eakins Julie , Darici Salihanur , Delp Johannes , Forsby Anna , Bennekou Susanne Hougaard , Gardner Iain , Leist Marcel , Danen Erik H. J. , Walker Paul , van de Water Bob , Jennings Paul 
Published: June 2020

Abstract Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies including metabolic diseases, accelerated ageing, neurodegenerative diseases and in certain xenobiotic-induced organ toxicity. Assessing mitochondrial perturbations is not trivial and the outcomes of such investigations are dependent on the cell types used and assays employed. Here we systematically investigated the effect of electron transport chain (ETC) inhibitors on multiple mitochondrial-related parameters in two human cell types, HepG2 and RPTEC/TERT1. Cells were exposed to a broad range of concentrations of 20 ETC-inhibiting agrochemicals and capsaicin, consisting of inhibitors of NADH dehydrogenase (Complex I, CI), succinate dehydrogenase (Complex II, CII) and cytochrome bc1 complex (Complex III, CIII). A battery of tests was utilised, including viability assays, lactate production, mitochondrial membrane potential (MMP) and the Seahorse bioanalyser, which simultaneously measures extracellular acidification rate [ECAR] and oxygen consumption rate [OCR]. CI inhibitors caused a potent decrease in OCR, decreased mitochondrial membrane potential, increased ECAR and increased lactate production in both cell types. Twenty-fourhour exposure to CI inhibitors decreased viability of RPTEC/TERT1 cells and 3D spheroid-cultured HepG2 cells in the presence of glucose. CI inhibitors decreased 2D HepG2 viability only in the absence of glucose. CII inhibitors had no notable effects in intact cells up to 10 µM. CIII inhibitors had similar effects to the CI inhibitors. Antimycin A was the most potent CIII inhibitor, with activity in the nanomolar range. The proposed CIII inhibitor cyazofamid demonstrated a mitochondrial uncoupling signal in both cell types. The study presents a comprehensive example of a mitochondrial assessment workflow and establishes measurable key events of ETC inhibition.
On the Average Case of MergeInsertion
Authors: Stober Florian , Weiß Armin 
Published: June 2020

AbstractMergeInsertion, also known as the Ford-Johnson algorithm, is a sorting algorithm which, up to today, for many input sizes achieves the best known upper bound on the number of comparisons. Indeed, it gets extremely close to the information-theoretic lower bound. While the worst-case behavior is well understood, only little is known about the average case. This work takes a closer look at the average case behavior. In particular, we establish an upper bound of $n \log n - 1.4005n + o(n)$
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comparisons. We also give an exact description of the probability distribution of the length of the chain a given element is inserted into and use it to approximate the average number of comparisons numerically. Moreover, we compute the exact average number of comparisons for n up to 148. Furthermore, we experimentally explore the impact of different decision trees for binary insertion. To conclude, we conduct experiments showing that a slightly different insertion order leads to a better average case and we compare the algorithm to Manacher’s combination of merging and MergeInsertion as well as to the recent combined algorithm with (1,2)-Insertionsort by Iwama and Teruyama.
Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5 year registry
Authors: Maruyama Shusaku , Ebisawa Souichiro , Miura Takashi , Yui Hisanori , Kashiwagi Daisuke , Nagae Ayumu , Sakai Takahiro , Kato Tamon , Saigusa Tatsuya , Okada Ayako , Motoki Hirohiko , Kuwahara Koichiro 
Published: June 2020

AbstractNutritional status is a novel approach to prognostic assessment in patients with cardiovascular disease. However, assessment of nutritional status in elderly patients is challenging due to the significant differences between young patients. The TCBI (Triglycerides × Total cholesterol × Body Weight Index) is a novel and simple nutritional index for predicting long-term outcomes in patients with coronary artery disease. This retrospective study evaluated the efficacy of TCBI in 597 elderly (≥ 75 years) patients enrolled in the SHINANO 5 year registry. The SHINANO 5 year registry, a prospective observational multicenter cohort study, had enrolled 1501 consecutive patients who underwent elective/urgent percutaneous coronary intervention (PCI). In this study, patients were categorized into TCBI quartile groups. The primary endpoints were the occurrence of major adverse cardiac and cerebrovascular events (MACCE), including all-cause death, stroke, and myocardial infarction at 5 year. The mean duration of follow up was 4.3 ± 1.7 years. The average patient age was 80.9 ± 4.3 years. MACCE was observed in 61 (40.9%) patients in the lowest TCBI quartile group. Kaplan–Meier analysis demonstrated an inverse relationship between MACCE and TCBI (log-lank P < 0.001). Multivariate analysis demonstrated that low TCBI significantly predicted the incidence of MACCE (hazard ratio: 1.44, 95% confidence interval: 1.03–2.00; P = 0.031). The TCBI is useful in predicting long-term outcomes in elderly patients undergoing PCI.
Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer
Authors: Beyer Susanne , Chen Fangfang , Meister Sarah , Czogalla Bastian , Kolben Theresa M. , Hester Anna , Burges Alexander , Trillsch Fabian , Schmöckel Elisa , Mayr Doris , Mayerhofer Artur , Mahner Sven , Jeschke Udo , Kolben Thomas 
Published: June 2020

AbstractSeveral risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this study, we evaluated and correlated the SIRT1 expression with patients’ tumor characteristics in endometrioid and clear-cell cancer of the uterus. 65 paraffin-embedded samples of patients with endometrial and clear-cell cancer of the uterus were immunohistochemically stained and SIRT1 expression was evaluated by immunoreactive score. The results were correlated to clinical and pathological tumor characteristics as well as to the expression of ARID1A and β-Catenin. The staining was significantly more intensive in uterine endometrioid carcinoma compared to uterine clear-cell carcinoma (p = 0.007). The expression of SIRT1 correlated significantly with the membranous expression of β-Catenin (p = 0.028) and ARID1A (p = 0.021). Patients with positive Sirtuin1 expression had a significantly better progression-free survival (p = 0.042), the overall survival showed a trend towards a better prognosis (p = 0.070). SIRT1 expression seems to be associated with improved progression-free survival in uterine cancer (endometrioid and clear-cell) and is correlated to the tumor suppressors β-Catenin and ARID1A. Further studies are necessary to elucidate the role of SIRT1 in uterine and ovarian cancer and its potential as a therapeutic target.
Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish
Authors: Bosze Bernadett , Ono Yosuke , Mattes Benjamin , Sinner Claude , Gourain Victor , Thumberger Thomas , Tlili Sham , Wittbrodt Joachim , Saunders Timothy E. , Strähle Uwe , Schug Alexander , Scholpp Steffen 
Published: June 2020

AbstractThe notochord defines the axial structure of all vertebrates during development. Notogenesis is a result of major cell reorganization in the mesoderm, the convergence and the extension of the axial cells. However, it is currently not fully understood how these processes act together in a coordinated way during notochord formation. The prechordal plate is an actively migrating cell population in the central mesoderm anterior to the trailing notochordal plate cells. We show that prechordal plate cells express Protocadherin 18a (Pcdh18a), a member of the cadherin superfamily. We find that Pcdh18a-mediated recycling of E-cadherin adhesion complexes transforms prechordal plate cells into a cohesive and fast migrating cell group. In turn, the prechordal plate cells subsequently instruct the trailing mesoderm. We simulated cell migration during early mesoderm formation using a lattice-based mathematical framework and predicted that the requirement for an anterior, local motile cell cluster could guide the intercalation and extension of the posterior, axial cells. Indeed, a grafting experiment validated the prediction and local Pcdh18a expression induced an ectopic prechordal plate-like cell group migrating towards the animal pole. Our findings indicate that the Pcdh18a is important for prechordal plate formation, which influences the trailing mesodermal cell sheet by orchestrating the morphogenesis of the notochord.
Solving visual object ambiguities when pointing: an unsupervised learning approach
Authors: Jirak Doreen , Biertimpel David , Kerzel Matthias , Wermter Stefan 
Published: June 2020

AbstractWhenever we are addressing a specific object or refer to a certain spatial location, we are using referential or deictic gestures usually accompanied by some verbal description. Particularly, pointing gestures are necessary to dissolve ambiguities in a scene and they are of crucial importance when verbal communication may fail due to environmental conditions or when two persons simply do not speak the same language. With the currently increasing advances of humanoid robots and their future integration in domestic domains, the development of gesture interfaces complementing human–robot interaction scenarios is of substantial interest. The implementation of an intuitive gesture scenario is still challenging because both the pointing intention and the corresponding object have to be correctly recognized in real time. The demand increases when considering pointing gestures in a cluttered environment, as is the case in households. Also, humans perform pointing in many different ways and those variations have to be captured. Research in this field often proposes a set of geometrical computations which do not scale well with the number of gestures and objects and use specific markers or a predefined set of pointing directions. In this paper, we propose an unsupervised learning approach to model the distribution of pointing gestures using a growing-when-required (GWR) network. We introduce an interaction scenario with a humanoid robot and define the so-called ambiguity classes. Our implementation for the hand and object detection is independent of any markers or skeleton models; thus, it can be easily reproduced. Our evaluation comparing a baseline computer vision approach with our GWR model shows that the pointing-object association is well learned even in cases of ambiguities resulting from close object proximity.
Single vs. multi-cone synchronizers with carbon friction lining—a comparison of load limits and deterioration behavior
Authors: Stockinger U. , Schneider T. , Pflaum H. , Stahl K. 
Published: June 2020

AbstractSynchronizers are widely used in gear boxes of car and truck transmissions. Optimizing costs and improving the efficiency of gear boxes require knowledge about the relative load limits of single and multi-cone synchronizers with carbon friction linings and their corresponding deterioration mechanisms. Load limits for single and multi-cone synchronizers with carbon friction lining used in cars were determined experimentally using the component test rig SSP-180 and compared against each other. Different load stages were run in life cycle tests and the influences of pressure, sliding velocity, friction work, frictional power and oil temperature were investigated. The synchronizers’ failure mode is described and the novel specific value μmin,grad is introduced that is able to quantify the deterioration of different synchronizer systems. During life cycle tests at the same specific load level, the single cone synchronizers, contrary to expectations, displayed greater damage compared to the multi-cone synchronizers. Calculations of the friction surface temperature in thermo-mechanical simulations, in combination with experiments on the test rig, show that the maximum temperature during the engagement has a significant influence on deterioration and endurance life of synchronizers with carbon friction lining.
Implementing a micromechanical model into a finite element code to simulate the mechanical and microstructural response of arteries
Authors: Bianchi Daniele , Morin Claire , Badel Pierre 
Published: June 2020

AbstractA computational strategy based on the finite element method for simulating the mechanical response of arterial tissues is herein proposed. The adopted constitutive formulation accounts for rotations of the adventitial collagen fibers and introduces parameters which are directly measurable or well established. Moreover, the refined constitutive model is readily utilized in finite element analyses, enabling the simulation of mechanical tests to reveal the influence of microstructural and histological features on macroscopic material behavior. Employing constitutive parameters supported by histological examinations, the results herein validate the model’s ability to predict the micro- and macroscopic mechanical behavior, closely matching previously observed experimental findings. Finally, the capabilities of the adopted constitutive description are shown investigating the influence of some collagen disorders on the macroscopic mechanical response of the arterial tissues.
A proposed unified framework to describe the management of biological invasions
Authors: Robertson Peter A. , Mill Aileen , Novoa Ana , Jeschke Jonathan M. , Essl Franz , Gallardo Belinda , Geist Juergen , Jarić Ivan , Lambin Xavier , Musseau Camille , Pergl Jan , Pyšek Petr , Rabitsch Wolfgang , von Schmalensee Menja , Shirley Mark , Strayer David L. , Stefansson Robert A. , Smith Kevin , Booy Olaf 
Published: June 2020

AbstractManaging the impacts of invasive alien species (IAS) is a great societal challenge. A wide variety of terms have been used to describe the management of invasive alien species and the sequence in which they might be applied. This variety and lack of consistency creates uncertainty in the presentation and description of management in policy, science and practice. Here we expand on the existing description of the invasion process to develop an IAS management framework. We define the different forms of active management using a novel approach based on changes in species status, avoiding the need for stand-alone descriptions of management types, and provide a complete set of potential management activities. We propose a standardised set of management terminology as an emergent feature of this framework. We identified eight key forms of management: (1) pathway management, (2) interception, (3) limits to keeping, (4) secure keeping, (5) eradication, (6) complete reproductive removal, (7) containment and (8) suppression. We recognise four associated terms: prevention; captive management; rapid eradication; and long-term management, and note the use of impact mitigation and restoration as associated forms of management. We discuss the wider use of this framework and the supporting activities required to ensure management is well-targeted, cost-effective and makes best use of limited resources.
Detection, assessment and mitigation of vulnerabilities in open source dependencies
Authors: Ponta Serena Elisa , Plate Henrik , Sabetta Antonino 
Published: June 2020

AbstractOpen source software (OSS) libraries are widely used in the industry to speed up the development of software products. However, these libraries are subject to an ever-increasing number of vulnerabilities that are publicly disclosed. It is thus crucial for application developers to detect dependencies on vulnerable libraries in a timely manner, to precisely assess their impact, and to mitigate any potential risk. This paper presents a novel method to detect, assess and mitigate OSS vulnerabilities. Differently from state-of-the-art approaches that depend on metadata to identify vulnerable OSS dependencies, our solution is code-centric, and combines static and dynamic analyses to determine the reachability of the vulnerable portion of libraries, in the context of a given application. Our approach also supports developers in choosing among the existing non-vulnerable library versions, with the goal to determine and minimize incompatibilities. , the open source implementation of our code-centric and usage-based approach is the tool recommended to scan Java software products at SAP; it has been successfully used to perform more than one million scans of about 1500 applications. In this paper we report on the lessons learned when maturing the tool from a research prototype to an industrial-grade solution. To evaluate , we conducted an empirical study to compare its detection capabilities with those of OWASP Dependency Check (), scanning 300 large enterprise applications under development with a total of 78165 dependencies. Reviewing a sample of the findings reported only by one of the two tools revealed that all findings are true positives, while 88.8% of the findings of for vulnerabilities covered by our code-centric approach are false positives. For vulnerabilities not caused by code but due, e.g., to erroneous configuration, 63.3% of findings are true positives.
A trend of increasing burned areas in Iraq from 2001 to 2019
Authors: Rasul Azad , Ibrahim Gaylan R. Faqe , Hameed Hasan M. , Tansey Kevin 
Published: June 2020

AbstractWildfires have an important role in the ecological process affecting ecosystems at multiple spatial scales. MCD64A1 500 m burned area product is used in this study to document trends of fire events from 2001 to 2019. The research aims to analyze the trend of burned areas in the country. Iraq is selected as study area of the research because of dramatically increasing the number of fires in the country. The study found that the lowest amount of burned areas were located in the center and southwest, while northeast and north faced most of the fires. The trend of burned areas in Iraq was an increase of 71.7 km2 per year, and, principally, in the last years, burned areas increased by 1363 km2. The most extensive burning areas occurred in the Ninawa Governorate (29%). In 2019, burned areas increased to around eight times compared to the yearly average. During 2019, one of the highest classes which contain burned area is “Cropland, rainfed” with 4366 km2 burned. High maximum air temperature and wind speed are the main factors that contribute to increasing burned areas; however, high precipitation and air pressure lead to a reducing amount of burned areas. The rapid increase of fires in the country as a result of burn crop field residues will lead to worsening air pollution and likely decrease forest area in the future.
Impact of local- and regional-scale restoration measures on a vulnerable rich fen in the Naardermeer nature reserve (the Netherlands)
Authors: Veeken Annegreet , Wassen Martin J. 
Published: June 2020

AbstractRestoration of rich fens is commonly attempted through local-scale measures, such as removal of sod or blockage of ditches. However, regional-scale restoration measures, that aim to re-establish the original hydrology in which rich fens developed, might have a more long-lasting effect. We investigated the effect of local- and regional-scale restoration measures on a vulnerable rich fen in the Naardermeer nature reserve in the Netherlands. We compared water quality and vegetation composition of the fen before and after the restoration measures, almost 30 years apart. Overall rich fen species increased and although this indicates the desired increased supply of fresh mineral-rich groundwater to the fen, continued succession towards poor fen vegetation has not been prevented in the entire fen. Despite sod layer removal, we observed an increase in a Polytrichum-dominated vegetation in patches that are primarily fed by rainwater. Our findings confirm results from a previous study which showed that brackish palaeo-groundwater is still contributing substantially to the water balance of the fen, especially in periods of precipitation deficit. We conclude that the local- and regional-scale restoration measures have been successful in increasing the abundance of rich fen species in parts of the fen. However, considering the pressures of climate change and high atmospheric N-deposition on the fen, it is uncertain whether rich fen species can be sustained in quite nutrient-poor conditions in the future. Therefore, there is a need for continued management that keeps the nutrient-poor and mineral-rich conditions of the fen intact.
How value co-creation and co-destruction unfolds: a longitudinal perspective on dialogic engagement in health services interactions
Authors: Keeling Debbie Isobel , Keeling Kathleen , de Ruyter Ko , Laing Angus 
Published: June 2020

AbstractComplex services, such as healthcare, struggle to realize the benefits of value co-creation due to the substantial challenges of managing such services over the long-term. Key to overcoming these challenges to value co-creation is a profound understanding of dialogue (i.e., ‘quality of discourse’ facilitating shared meaning) during service interactions. Contributing to an emerging literature, we undertake a longitudinal, ethnographic study to assess dialogue between professionals and patients through the lens of dialogic engagement (i.e., iterative mutual learning processes that bring about action through dialogue). We develop and empirically support six dialogic co-creation and co-destruction mechanisms that impact on the resolution of tensions and integration of knowledge resources between service providers and consumers. We reveal the multidimensional and dynamic nature of value created or destroyed through these mechanisms in dialogue over time. Taking healthcare as an exemplar, we offer a research agenda for developing our understanding of DE in complex services.