bluuebunny/crossref_metadata_2025_split huggingface dataset:
First archaeological investigations of barrows in the Bačka region and the question of the Eneolithic/Early Bronze Age barrows in Vojvodina
Authors: Koledin Jovan , Bugaj Urszula , Jarosz Paweł , Novak Mario , Przybyła Marcin M. , Podsiadło Michał , Szczepanek Anita , Spasić Miloš , Włodarczak Piotr 
Published: June 2020

Abstract
In various prehistoric periods, the territory of Vojvodina became the target of the migration of steppe communities with eastern origins. The oldest of these movements are dated to the late Eneolithic and the beginning of the Early Bronze Age. There are at least two stages among them: I – dated to the end of the fourth millennium BC / beginning of the third millennium BC and II – dated from 3000 to 2600 BC and combined with the communities of the classical phase of the Yamnaya culture. The data documenting these processes have been relatively poor so far – in comparison with the neighboring regions of Bulgaria, Romania and Hungary. A big drawback was the small number of systematically excavated mounds, providing comprehensive data on the funeral ritual of steppe communities. This poor database has been slightly enriched as a result of the design of the National Science Centre (Cracow, Poland) entitled “Danubian route of the Yamnaya culture”. Its effect was to examine the first two barrows located on the territory of Bačka – the western region of Vojvodina. Currently, these burial mounds are the westernmost points on the map of the cemeteries of the Yamnaya culture complex. Radiocarbon dates obtained for new finds, as well as for archival materials, allow specifying two stages of use of cemeteries of Yamnaya culture: I – around 3000–2900 BC and II – around 2800–2600 BC. Among the finds from Banat, there were also few materials coming probably from the older period, corresponding to the classical phase of Baden – Coţofeni I–II. The enigmatic nature of these discoveries, however, does not allow to specify their dating as well as cultural dependencies.
Geopolítica y Medio Ambiente: Incidencia del cambio climático y los intereses geopolíticos en el Ártico
Authors: Johanning Solís Javier , Peña Menjivar Carlos Alberto 
Published: June 2020

La investigación procura indagar sobre los intereses subyacentes que giran alrededor de la zona del Ártico. Esta región ha cobrado una mayor importancia en las relaciones internacionales producto del cambio climático y el deshielo que el calentamiento global ha supuesto en la región, despertando intereses económicos, políticos y estratégicos en los principales Estados Árticos. Para comprender cuáles son los intereses de los Estados Árticos se realiza un análisis del complejo de régimen internacional que ha sido construido en el Ártico, y luego se indaga sobre las principales políticas y acciones llevadas a cabo por los principales Estados involucrados en la región. Se encuentra que el complejo de régimen internacional relacionado al Ártico es sumamente fragmentado y débil, lo que ha facilitado que los Estados persigan sus intereses de forma más abierta en la región, provocando que aumenten las tensiones entre Rusia y el resto de los Estados, y que incluso otros actores antes no involucrados se inserten en la región, como China, provocando recelos. No obstante, se encuentra que la situación internacional actual no es propicia para una escalada en la competencia por el poder en el Ártico, al menos en un corto o mediano plazo, pero podría aumentar más adelante producto del deterioro ambiental, producto de una la lucha por la protección del ambiente ambigua y contradictoria por parte de los Estados Árticos.
Nėščiųjų ir pagimdžiusiųjų hemorojus ir išangės įplėša: paplitimas, rizikos veiksniai bei įtaka moters gyvenimo kokybei
Authors: Bužinskienė Diana , Drąsutienė Gražina , Poškus Tomas 
Published: June 2020

Šio straipsnio tikslas – apžvelgti literatūrą, nagrinėjančią nėščiųjų hemorojaus ir išangės įplėšos paplitimą, priežastis, dažnį, rizikos veiksnius bei šių ligų įtaką moterų gyvenimo kokybei.Išangės ligos (hemorojus ir išangės įplėša) tiek nėštumo metu, tiek laikotarpiu po gimdymo yra dažna patologija, kuriai vis dar stinga tiek koloproktologų, tiek akušerių ginekologų dėmesio. Šiuo metu nėra tyrimų, kuriuose perspektyviuoju būdu nėštumo metu ir po gimdymo būtų vertinamas išangės ligų atsiradimas, nustatomi jų rizikos veiksniai. Labai svarbu ištirti ir įvertinti šių ligų paplitimą Lietuvoje ir rizikos veiksnius, jų ryšį su nėštumo ir gimdymo veiksniais, laiku šias ligas diagnozuoti ir gydyti bei atrasti priemonių, kaip jų išvengti, taip pagerinant moterų gyvenimo kokybę ne tik nėštumo ir gimdymo metu, bet ir laikotarpiu po gimdymo.Reikšminiai žodžiai: hemorojus, išangės įplėša, nėštumas, gimdymas, rizikos veiksniai, gyvenimo kokybė
Hemorrhoids and anal fissures during pregnancy and after childbirth: prevalence, risk factors and impact on women’s quality of lifeDiana Bužinskienė, Gražina Drąsutienė, Tomas Poškus
The aim of this study was to review the literature regarding the incidence, prevalence, risk factors of hemorrhoids and anal fissures during, before, and after pregnancy and their impact on the quality of life of women.Both hemorrhoids and anal fissures are common during and after pregnancy; however, they are frequently overlooked by both coloproctologists and gynecologists. There are no prospective cohort studies of perianal diseases during and after pregnancy with an emphasis on identifying the possible risk factors. Thus, it is important to identify the incidence and risk factors of perianal diseases in Lithuania and to find the factors of pregnancy and delivery that could be related to the occurrence or prevent the occurrence of these diseases. In this way, the possible areas of correction and intervention could be identified.Key words: hemorrhoids, anal fissure, pregnancy, delivery, risk factors, quality of life
Chirurgai ir akademinės chirurgijos raida Kaune 1919–1940 metais
Authors: Zykas Vytautas 
Published: June 2020

Straipsnyje apžvelgiama chirurgijos raida nepriklausomoje Lietuvoje 1919–1940 metais. Pateikiami duomenys apie pirmuosius žingsnius organizuojant ir kuriant chirurgijos discipliną Aukštuosiuose kursuose ir vėlesnį jos vystymąsi universiteto Medicinos fakultete Kaune. Aprašoma iškiliausių to laikotarpio chirurgų J. Žemgulio, J. Dzirnės, H. Boito, A. Hagentorno, V. Kanaukos, V. Kuzmos, A. Maciūno, J. Čeponio, J. Jaržemsko ir kt. veikla kuriant praktinę ir akademinę chirurgiją Kaune ir Lietuvoje, aptariamas jų indėlis į mokslą, Lietuvos chirurgų draugijos organizavimą, pirmojo periodinio lietuviško žurnalo „Medicina“ steigimą. Pateikiami svarbesni faktai apie šių iškilių asmenybių visuomeninę veiklą, jų tragiškus likimus istorijos posūkiuose.

Surgeons and academic surgery in Kaunas between 1919–1940Prof. habil. dr. Vytautas Zykas
This article offers an historical overview of the development of surgery in Lithuania during the years of independence between 1919 and 1940. It describes the first steps of the creation of academic surgery and it‘s later development in the Universtity in Kaunas. The paper depicts facts about the prominent surgeons of that period – J. Žemgulys, J. Dzirnė, H. Boit, A. Hagentorn, V. Kanauka, A. Maciūnas, J. Čeponis, J. Jaržemskas and others who achieved major developments of practical and academic surgery, scientific works, organization of the Lithuanian Society of Surgeons and establishment of the first Lithuanian periodic medical journal „Medicina“. Some interesting facts about the public and social roles of those prominent personalities and the tragedy many of them lived at this turn of history are also presented.
Treatment of chronic colorectal fistula with the over-the-scope-clipping system: a case report
Authors: Aliosinas Olegas , Radziunas Gintautas , Dulskas Audrius , Samalavicius Narimantas E. 
Published: June 2020

Anastomotic leakage in colorectal surgery is an infrequent but in some cases very serious or even lethal complication. The over-the-scope-clipping (OTSC) system (Ovesco), which was originally developed to treat intestinal perforation and was tested on animals, could be the answer for the patient with such situation. We present a case of 63-year-old man suturae insuffitiency at the 40th post-operative day. The conservative treatment was long and unsuccessful. The lesion was then closed with two subsequent clips, and the patient recovered well without major interventions. The lesion showed a normal healing on the follow-up.
Naujas perforavusio dvylikapirštės žarnos divertikulo gydymas atliekant Roux-en-Y duodenojejunostomiją
Authors: Šileikis Audrius , Šileikytė Auksė 
Published: June 2020

Dvylikapirštės žarnos divertikulai yra dažniausia divertikuliozės vieta plonojoje žarnoje. Nuo 1 % iki 5 % tokių divertikulų yra simptominiai ir pasireiškia skausmu, kraujavimu, uždegimu, cholestaze, cholangitu, obstrukcija, perforacija, pankreatitu ar piktybine transformacija. Pati sudėtingiausia komplikacija yra perforacija, kuri sudaro 0,03 %. Diagnozavus dvylikapirštės žarnos divertikulo perforaciją, tradicinis gydymas buvo paprasta divertikulektomija ir dvylikapirštės žarnos užsiuvimas dviem sluoksniais su retroperitoninio tarpo drenavimu. Pastaruoju metu aprašoma vis daugiau sėkmingų konservatyvaus ir kitokio chirurginio gydymo atvejų. Mes aprašome savo patirtį, susijusią su dvylikapirštės žarnos divertikulito gydymu atliekant Roux-en-Y duodenojejunostomiją Shigeru Fujisaki metodu po nesėkmingo konservatyvaus gydymo.
Barrett's Esophagus and Intestinal Metaplasia of Gastric Cardia: Prevalence, Clinical, Endoscopic and Histological Features
Authors: Pascarenco Ofelia Daniela , Boeriu Alina , Mocan Simona , Pascarenco Ghenadie , Drasoveanu Silvia , Galeanu Marinela 
Published: June 2020

Background & Aims: Over the past few decades, the incidence of adenocarcinomas of the gastroesophageal junction has rapidly increased. Barrett's esophagus is a risk factor for esophageal adenocarcinoma, but the role of intestinal metaplasia of the gastric cardia as a precursor in cardia-related cancer is controversial. The aims of the present study were to examine the prevalence of intestinal metaplasia in the gastroesophageal junction and to evaluate the clinical, endoscopical and histological features of patients with intestinal metaplasia in the gastric cardia and patients with Barrett's esophagus.Methods: 286 consecutive patients undergoing gastroduodenoscopy were enrolled in a prospective study. Biopsy specimens were performed in the distal esophagus, squamocolumnar junction, gastric cardia, gastric corpus and antrum.Results: We identified 44 patients (15.3%) with intestinal metaplasia in biopsies from gastric cardia and 24 patients (8.3%) with Barrett's esophagus. Cardia intestinal metaplasia was significantly associated with older age (p=0.03), with intestinal metaplasia in the antrum (p=0.017) and H. pylori infection (p<0.0001). Severe chronic cardia inflammation increased the presence of cardia intestinal metaplasia 6.2 fold (OR=6.288; p<0.0001). Patients with Barrett's esophagus were predominantly men. Barrett's esophagus presence significantly correlated with reflux symptoms(p<0.0001), endoscopic esophagitis (p<0.0001) and hiatal hernia >2 cm (p=0.002). No patient had dysplasia in the gastroesophageal region.Conclusions: Presence of intestinal metaplasia at the gastroesophageal region correlated with reflux symptoms and endoscopic signs of reflux disease in patients with Barrett's esophagus and with H.pylori infection and distal intestinal metaplasia in patients with cardia intestinal metaplasia.Abbreviations: BE- Barrett_s esophagus; CIM- cardia intestinal metaplasia; CLE- columnar lined esophagus; GEJ- gastroesophageal junction; GERD - gastroesophageal reflux disease; IM- intestinal metaplasia; LSBE- long segment Barrett's esophagus; SCJ - squamocolumnar junction; SSBE- short segment Barrett's esophagus; USSBE- ultrashort segment Barrett's esophagus.
Relationship between NT-proBNP and Cardio-Renal Dysfunction in Patients with Advanced Liver Cirrhosis
Authors: Cavasi Adriana , Cavasi Eduard , Grigorescu Mircea , Sitar-Taut Adela 
Published: June 2020

Background & Aims: ProBNP is a sensitive marker of cardiac dysfunction. We assessed the concentration of circulating NT-proBNP in patients with liver cirrhosis in various stages of the disease and its correlation with markers of cardiac and renal dysfunction and with markers of liver disease severity.Patients and methods: A number of 88 patients with liver cirrhosis were included in the study, divided into 3 groups: group 1 - 18 control patients without ascites; group 2 - 35 non-azotemic patients with ascites; group 3 - 35 patients with hepatorenal syndrome. The cardiac dysfunction was assessed by measuring the NT-proBNP serum levels and the QTc interval. The markers of renal dysfunction were the estimated glomerular filtration rates - formulas involving creatinine and serum cystatin C. The Child-Pugh score was used to assess the liver disease severity.Results: The median NT-proBNP serum levels significantly increased in patients with advanced liver cirrhosis (group 3: 960 fmol/ml and group 2: 660 fmol/ml) as compared to group 1 (435 fmol/ml) (p<0.05). A significant direct correlation was found between the NT-proBNP concentration and the QTc interval (r=0.540, p<0.001). The NT-proBNP levels also correlated with the Child-Pugh score (r=0.501, p<0.01), proving the link between the cardiac dysfunction and the liver disease severity. The cardio-renal interrelation is supported by the relationship between the NT-proBNP concentration and the estimated clearances.Conclusion: The high NT-proBNP levels in patients with advanced cirrhosis indicate the presence of cardiac dysfunction, which has a role in the pathogenesis of the hepatorenal syndrome.Abbreviations: DP: diastolic pressure; GFR: glomerular filtration rate; HRS: hepatorenal syndrome; MAP:mean arterial pressure; NT-proBNP: N-terminal fragment of the prohormone B-type natriuretic peptide; proBNP: prohormone brain natriuretic peptide; SBP: spontaneous bacterial peritonitis; SP: systolic pressure; TIPS: tranjugular intrahepatic portosystemic shunt.
Intervenciones psicológicas en el tratamiento de la ansiedad en personas con cáncer de mama: un meta-análisis
Authors: Zelaya-Rivas Susana María 
Published: June 2020

Objetivo. Esta investigación busca estimar el tamaño del efecto de las intervenciones psicológicaspara el tratamiento de la ansiedad en personas con cáncer de mama. Método. Se realizó una revisión sistemática de bases de datos en línea (Dialnet, Ebsco, Latindex, PubMed, ScienceDirect, Wiley, SAGE, Scielo y Google Scholar), a través de la cual se extrajeron artículos experimentales y cuasi-experimentales relevantes para el tema de estudio. De los artículos seleccionados, se extrajeron datos de las participantes, los tratamientos utilizados y datos pretest y postest de los grupos para el análisis. Resultados. Diecisiete artículos que cumplieron los criterios de inclusión fueron agregados en el análisis. El tamaño de efecto global de las intervenciones fue de (g = -.459). Asimismo, se realizaron análisis de sesgo y de variables continuas moderadoras.
Tindak Pidana Kekerasan di Desa Duduk Sampeyan dalam Perspektif Hukum Pidana Islam
Authors: Sutomo Budi 
Published: June 2020

The criminal acts that often happen in people's lives are related to a violent crime, one of which occurred in Duduk Sampean Gresik, which has the court decision. This paper aims to analyze the decision of the Gresik district court regarding the violent crime that occurred in Duduk Sampean. This paper concludes three things in this research, namely: (1) the three individuals are Muslims and they are mukallaf who are responsible for their jari>mah (Illegal act or ommission), their action is classified as jari>mah tawa>fuq so that each one is only responsible for their owns actions; (2) the imprisonment imposed by the Gresik District Court is classified as a ta'zi>r sentence which falls under the authority of ulil amri or the government even though it has been freed from the qis}a>s punishment and diyah for getting forgiveness; and (3) the restitution received by the victim constitutes the realization of the legal liability of the offender for obtaining forgiveness.
Sejarah Hukum Lingkungan di Indonesia
Authors: Mubarok Nafi' 
Published: June 2020

In conjunction with the development of contemporary Islamic law in Muslim countries, the question that frequently arises is about the formalization of Islamic law (taqnin). In Indonesia, the aspirations of Islamic Law's codification, particularly concerning its implementation crystallized into three forms; (1) formal (2) substantive, and (3) essential. One of the experts of Islamic law in Indonesia who concerned about the development of Islamic law was Sjechul Hadi Permono. This paper aims to explain the significance of Sjechul Hadi Permono's Legal Thought about Zakat. According to Sjechul Hadi Permono, the discourse on the people's welfare that is the burden of the state will always become a hot topic. Unfortunately, this problem has nerver been investigated based on the Islamic conception of welfare and the idea of Islam as an instrument of refom in society. This is a formula Sjechul Hadi tries to offer that zakat if properly managed will offer a solution to the welfare problem.
Peran Lembaga Kepolisian dalam Perspektif Fiqh Siyasah
Authors: Pangestuti Diah Sari 
Published: June 2020

Looking at the crime statistic, it shows the continuous increase of crime either in number and quality. Even more varied and creative. Therefore, in order to produce internal security and to maintain the wellbeing of the people, a special institution is needed to handle it, namely the Police Agency. By using normative legal research and combining it with an analytical approach in order to analyze the data descriptively and inductively, this study tries to determine the role of the Police agency based on Fiqh Siyasah. It is concluded that: firstly, in Indonesian, there is a Police Agency that is a state instrument that plays a role in maintaining public order and security, enforcing the law, providing protection and services to the public. Secondly, in Islamic Law, there is the Muhtasib Institution, which has a supervisory and controlling body. Thirdly, that the Police in Islamic and Indonesian Law has almost the same duties that are as law enforcement to maintain security and public order. However, because of the law in Islam covers both mu'amalah and 'ubudiyyah aspects, so the scope of police responsibility in Islam is broader.
Model Moderasi Beragama Berbasis Pesantren Salaf
Authors: Nurdin Ali , Syahrotin Naqqiyah Maulidatus 
Published: June 2020

Nahdlatul Ulama adalah salah satu organisasi Islam terbesar di Indonesia yang memiliki dan mengedepankan prinsip tawasut} (moderat). Pondok Pesantren Salaf Al-Anwar merupakan salah satu pondok pesantren berbasis paham Nahdlatul Ulama’ dan menganut ajaran Ahl as-sunnah wa al-Jama>ah. Tujuan penelitian ini adalah untuk memahami dan mendeskripsikan model moderasi beragama yang dikembangkan dan diimplementasikan Pondok Pesantren Salaf Al-Anwar, Sarang, Rembang, Jawa Tengah. Penelitian ini menggunakan jenis deskriptif-kualitatif dengan data penelitian yang diperoleh dari hasil wawancara dengan informan dan hasil pengamatan. Hasil penelitian ini mendeskripsikan bahwa model moderasi beragama yang dilakukan di Pondok Pesantren Al-Anwar adalah model penerapan sistem pendidikan dengan berbasis kurikulum salafi dengan materi pesan berbasis pada kitab-kitab tura>th. Model ini merupakan salah satu media yang efektif dalam menanamkan sikap moderat bagi para santri dan masyarakat. Kiai sebagai pewaris perjuangan para ulama’ memiliki kredibilitas yang kuat dalam menanamkan sikap moderat bagi para santri dan masyarakat. Implementasi moderasi beragama di pesantren dapat dilakukan melalui sikap dan perilaku santri yang selalu berpedoman pada dua prinsip pemikiran yang telah ditanamkan dan dikembangkan di pesantren, yaitu; pertama, santri harus memiliki keilmuan khusus sebagai bekal untuk dirinya sendiri dan ilmu umum untuk menghadapi masyarakatnya. Kedua, santri dalam menyelesaikan problema masyarakat dan bangsa harus selalu merujuk kepada empat pilar bangsa, yang disingkat PBNU, yaitu; Pancasila, Bhinneka Tunggal Ika, Negara Kesatuan Republik Indonesia (NKRI), dan Undang-Undang Dasar 1945
Phase I Study of Ramucirumab Plus Merestinib in Previously Treated Metastatic Colorectal Cancer: Safety, Preliminary Efficacy, and Pharmacokinetic Findings
Authors: Saleh Mansoor , Cassier Philippe A. , Eberst Lauriane , Naik Gurudatta , Morris Van K. , Pant Shubham , Terret Catherine , Gao Ling , Long Amanda , Mao Huzhang , McNeely Samuel , Wagner Erin K. , Carlesi Roberto M. , Fu Siqing 
Published: June 2020

Abstract

Trial Information
Click here to access other published clinical trials.

Lessons Learned
The combination of the antivascular endothelial growth factor receptor 2 monoclonal antibody, ramucirumab, and the type II MET kinase inhibitor, merestinib, is tolerable. Preliminary efficacy data suggest that the combination may provide clinical benefit to patients with metastatic colorectal cancer (mCRC). Further development of this combination would likely necessitate the identification of subsets of patients with mCRC where the clinical benefit is of clinical relevance.

Background
This study evaluated safety, preliminary efficacy, and pharmacokinetics of ramucirumab plus merestinib in patients with MCR previously treated with oxaliplatin and/or irinotecan.

Methods
Open-label phase Ia/b study comprising 3+3 dose-limiting toxicity (DLT) observation and expansion parts. Treatment was ramucirumab 8 mg/kg on days 1 and 15 and merestinib 80 mg once daily (QD; 28-day cycle). Primary objective was safety and tolerability. Secondary objectives were pharmacokinetics and preliminary antitumor activity. Exploratory objective was biomarker associations.

Results
Safety findings: DLT (proteinuria) of 7 phase Ia patients (the expansion part started at the initial recommended dose level); 16 patients (70%) with grade ≥3 treatment-emergent adverse events (TEAEs); 10 patients (43%) with grade ≥3 treatment-related TEAEs. The most common grade ≥3 treatment-related TEAEs were fatigue (4 patients [17%]) and increased blood alkaline phosphatase, diarrhea, and hypertension (2 patients each [9%]). One patient discontinued treatment because of cholestatic hepatitis. Geometric mean trough concentrations at cycle 1, day 15, were ramucirumab, 24.8 μg/mL; merestinib, 130 ng/mL. No complete or partial response was seen; 12 patients (52%) achieved stable disease. Median progression-free survival was 3.3 months (95% confidence interval [CI]: 1.6–4.4). Median overall survival was 8.9 months (95% CI: 3.5–12.7). There were no associations between genetic alterations and efficacy.

Conclusion
Ramucirumab plus merestinib is tolerable and may have clinical benefit in biomarker-unselected, heavily pretreated patients with mCRC.