bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embedded Internet of Things Applications of SQLite Based on WinCE Mobile Terminal
Authors: Yu Yuanhui 
Published: September 2020

Abstract
As we all know, embedded systems are becoming more and more widely used. All devices with digital interfaces, such as watches, microwave ovens, video recorders, automobiles, etc., use embedded systems, but most embedded systems are implemented by a single embedded application program to achieve the entire control logic.At present, embedded applications on the WinCE platform are extending towards microservices and miniaturization. More embedded device application data requires small, embedded database systems to organize, store, and manage. The embedded database SQLite has many advantages such as zero-configuration, lightweight, multiple interfaces, easy portability, readable source code, and open source. It is currently widely used in the WinCE embedded operating system. This article discusses the technical characteristics of the SQLite database in detail, SQLite data manipulation, SQLite transplantation under the WinCE platform, and finally implements SQLite data management on WinCE mobile terminal based on MFC programming.
Low-voltage and fully flexible analogue/digital mixed-signal circuits based on carbon nanotubes for epidermal sensor applications
Authors: Kashima Taikga , Kishimoto Shigeru , Hirotani Jun , Kataura Hiromichi , Ohno Yutaka 
Published: September 2020

Abstract
Epidermal electronics that can be mounted directly onto human skin to monitor biological signals have wide applicability, such as in healthcare and sports. This requires integrating various analogue and analogue/digital mixed-signal circuits on a flexible film as well as sensors. Flexible analogue circuits based on oxide semiconductors or amorphous Si have been realised, but so far they do not allow robust digital signal transmission to an external system, and they have a high operating voltage. Here, we report a low-voltage and fully flexible analogue/digital mixed-signal circuits based on carbon nanotubes (CNTs). The key contribution is a novel operational amplifier with a high gain and low operating voltage, which is important for negative-feedback circuits and dramatically suppresses the influence of device variability and instability. Fully flexible CNT-based mixed-signal circuits were realised monolithically on a plastic film for the first time and demonstrated stable and continuous operation at a low supply voltage.
Correlations between&nbsp;Morphine Use and Adverse Outcomes in Acute ST-Segment Elevation Myocardial Infarction with Acute Heart Failure: a retrospective study&nbsp;
Authors: dong shaohong , Lin Yaowang , Yuan Jie , Zhu Yong , Liu Huadong , Pang Xinli 
Published: September 2020

Abstract
Background: Studies examining the safety of intravenous morphine use for acute heart failure (AHF) have reported inconsistent results. Objective: The comprehensive meta-analysis assessed and compared the clinical outcomes of intravenous morphine use in AHF.Methods: We formally searched electronic databases before June 2020 to identify potential studies. All clinical trials were eligible for inclusion if they compared intravenous morphine or not in patients with AHF.Results: 3 propensity-matched cohorts and 2 retrospective analysis with a total of 151867 patients met the inclusion criteria were included in our meta-analysis (intravenous morphine group=22072, without morphine group=127895). The use of intravenous morphine was associated with increased risk of in-hospital mortality [over all odds ratio (OR)=5.49, 95% confidence interval (CI) 5.20 to 5.79, p<0.001, I2=96.7%; subgroup analysis: OR=1.60, 95%CI 1.27-2.02, I2=0%; OR=1.53, 95%CI 1.20-1.96, I2=7%] and invasive mechanical ventilation (OR=6.08, 95% CI 5.79 to 6.40, p<0.001, I2=94.2%; subgroup analysis: OR=1.74, 95%CI 1.21-2.49, I2=62.3%). However, there was no significant association of longtime time mortality with intravenous morphine (Hazards ratio =1.17; 95% CI 0.99–1.36, p=0.14; I2 32%).Conclusion: In AHF patients, intravenous morphine administration for relieving dyspnea was associated with in-hospital mortality and invasive mechanical ventilation, but not for longtime mortality.
Observation of non-Bloch parity-time symmetry and exceptional points
Authors: Xue Peng , Xiao Lei , Deng Tianshu , Wang Kunkun , Wang Zhong , Yi Wei 
Published: September 2020

Abstract
Parity-time (PT)-symmetric Hamiltonians have widespread significance in non-Hermitian physics. A PT-symmetric Hamiltonian can exhibit distinct phases with either real or complex eigen spectrum, while the transition points in between, the so-called exceptional points, give rise to a host of critical behaviors that holds great promise for applications. For spatially periodic non-Hermitian systems, PT symmetries are commonly characterized and observed in line with the Bloch band theory, with exceptional points dwelling in the Brillouin zone. Here, in non-unitary quantum walks of single photons, we uncover a novel family of exceptional points beyond this common wisdom. These "non-Bloch exceptional points" originate from the accumulation of bulk eigenstates near boundaries, known as the non-Hermitian skin effect, and inhabit a generalized Brillouin zone. Our finding opens the avenue toward a generalized PT-symmetry framework, and reveals the intriguing interplay among PT symmetry, non-Hermitian skin effect, and non-Hermitian topology.
ES-MDA: Enhanced Similarity-based MiRNA-Disease Association
Authors: Xu Li , Jiang Ge-Ning 
Published: September 2020

:
Accumulating evidence demonstrate that miRNAs can be treated as critical biomarkers
in various complex human diseases. Thus, the identifications on potential miRNA-disease associations
have become a hotpot for providing better understanding of disease pathology in this field.
Recently, with various biological datasets, increasingly computational prediction approaches have
been designed to uncover disease-related miRNAs for further experimental validation. To improve
the prediction accuracy, several algorithms integrated miRNA similarities of known miRNA-disease
associations to enhance the miRNA functional similarity network and disease similarities of
known miRNA-disease associations to enhance the disease semantic similarity network. It is anticipated
that machine learning methods would become an effective biological resource for clinical experimental
guidance.
Inducing Tumor Cell Apoptosis: Mediated Survivin miRNA by Ultrasound and Cationic Lipid Contrast Agent
Authors: Yang Feng , Chun Liu-Fu , Chen Zhi-Yi 
Published: September 2020

Background:
Non-viral delivery systems is a promising method for gene or
drug delivery. Polyethyleneimine (PEI) is a double-edged sword. It internalizes itself into
the cell through endocytosis and promotes gene transfer efficiency. However, the strong
positive charge also makes PEI highly toxic to cells. Ultrasound-targeted microbubble
destruction (UTMD) is a promising non-viral method for gene and drug delivery, but its
efficiency still needs to be improved.

Objective:
The aim of this study was to explore a system that combines ultrasound with
non-viral gene delivery for the treatment of cervical cancer HeLa cells.

Methods:
In this study, we synthesized a kind of cationic ultrasound contrast agent(CUCA)
that the physical and chemical properties, gene carrying capacity and cytotoxicity
were verified. On the basis of previous studies, we further optimized the following
transfusion parameters including ultrasound parameters, microbubble concentration,
plasmid concentration, cell density and other parameters. The experiment was designed
to compare the following six groups: (1) Plasmid group (P group), plasmid 15 μg; (2) PEI
+ plasmid group (PEI + P group),1 μl of PEI containing 10 nmol nitrogen and 1 μg of
DNA containing 3 nmol phosphate for a PEI/DNA ratio equal to a nitrogen/phosphate
ratio of 7 for transfection; (3) Ultrasound + plasmid group (US + P), plasmid 15 μg; (4)
Ultrasound + cationic liposomal ultrasound contrast agent + plasmid group (UTMD + P
group), plasmid 15 μg and cationic liposomal ultrasound contrast agent 5%; (5)
Ultrasound + cationic liposomal ultrasound contrast agent + PEI + plasmid group (UTMD
+ PEI + P group), PEI/DNA ratio equal to a nitrogen/phosphate ratio of 7 for transfection
and cationic liposomal ultrasound contrast agent 5%; and (6) Blank group, no
treatment), The influence on Hela cells was observed under microscope, the efficiency
of apoptosis was measured by flow cytometry, and cell viability was tested in CCK 8.

Results:
The optimized transfection parameters can improve the transfection efficiency
of ultrasound combined with C-UCA to a certain extent, but its transfection efficiency is
still lower than that of branched polyethyleneimine (bPEI) 25 kDa. By investigating the
effect of HeLa cells apoptosis induced by UTMD in combination with PEI mediated
survivin miRNA, we found that both PEI alone and ultrasound in combination with CUCA
were able to transfect cells with survivin miRNA to effectively induce HeLa cell
apoptosis. However, the synergistic effect between the two methods was not significant.

Conclusion:
In contrast, the combined use of ultrasound, C-UCA and PEI may
significantly reduce the transfection efficiency of UTMD and PEI, and the specific
mechanism remains to be further studied.
Madhuca longifolia Embedded Silver Nanoparticles Attenuate Diethylnitrosamine (DEN)-Induced Renal Cancer via Regulating Oxidative Stress
Authors: Singh Deepika , Yadav Ekta , Kumar Vikas , Verma Amita 
Published: September 2020

Objective:
Madhuca longifolia has been used for the treatment of renal cancer. Therefore, the current study describes the protective effects of biofabricated silver nanoparticles (MLAgNPs) using Madhuca longifolia aqueous leaves extract against diethylnitrosamine (DEN) induced renal cell carcinoma (RCC) in rats.

Methods:
Animals were categorized into five groups and treated with doses of silver nanoparticles for 16 weeks. Antineoplastic effect in renal cancer was dose dependent to control the macroscopical variations when compared to DEN induced group. Significant changes were observed in biochemical parameters and dose graded improvement in the level of antioxidants parameters were accountable for its protective nature.

Result:
Silver nanoparticles in dose dependent manner was effective to modify the raised levels of
pro-inflammatory cytokines and inflammatory mediators during renal cancer. Alteration in renal
histopathology were also detected in the silver nanoparticles treated group, which show its safety
concern. Biofabricated silver nanoparticles (MLAgNPs) using Madhuca longifolia can convey significant
chemo-protective effect against renal cancer by suppressing the IL-6, TNF-α and IL-1β by
nuclear factor-kappa B (NF-κB) pathway.

Conclusion:
Our outcomes implicates that biofabricated MLAgNPs exhibited a chemoprotective potential in the prevention
and intervention of RCC.
Nutritional, Biochemical and Haematological Indices of White Albino Rats Fed Complementary Diets Developed from Selected Cereals and Legumes
Authors: Yohannes Tsehayneh G. , Makokha Anselimo O. , Okoth Judith K. , Tenagashaw Mesfin W. 
Published: September 2020

Background:
Childhood malnutrition is a common public health problem in Ethiopia.
This animal study aims to evaluate the haematological, biochemical, and nutritional indices of
weanling albino rats fed on complementary diets developed from selected cereals and legumes.

Methods:
The nutritional qualities of the formulated blends were assessed biologically by feeding
white albino rats in order to determine feed intake, the growth rate, protein quality parameters, biochemical
and haematological properties. The commercial weaning diet (cerifam) and casein were
used as control diets. On the 28th day, blood samples were collected from three randomly selected
rats by decapitation. Full blood count analysis was carried out using the Automated Haematologic
Analyzer to determine haematological parameters. All the biochemical parameters were determined
using Mindray diagnostic kits.

Results and Discussion:
The food intake pattern showed that animals placed on diet 3, diet 4, casein,
and cerifam consumed more food than those fed on diet 1, diet 2, and diet 7. The mean
growth rate of animals fed on diet 3 and diet 4 was significantly (p<0.05) higher than those placed
on diet 1, diet 2, and diet 7 but similar to those fed with commercial diet and casein. The protein
quality evaluation of the diets showed that the protein efficiency ratio ranged from 1.20 to 2.43
while the biological value was in the range of 54.53 to 69.48%. The net protein utilization and true
digestibility were 65.62 to 70.21% and 59.01 to 64.01%, respectively. Serum total protein, albumin,
and globulin levels in rats given diet 3 and diet 4 were comparable to the controls and within
the normal range. Comparatively, the creatinine and urea levels of rats fed on the control and formulated
diets were within the normal range. The serum alanine aminotransferase values of rats fed
on the control and formulated diets ranged from 22.03 IU/L in diet 2 to 37.76 IU/L in diet 4 and
were not significantly different from each other. In this study, the packed cell volume and haemoglobin
values of the control and formulated diets were within the recommended range. Evidently,
diet 3 and diet 4 gave the best growth performance after the feeding trials.

Conclusion:
The haematological and biochemical indices indicate that these diets can support effective
growth and development in rats, and consumption of these diets has no detrimental effects
on the liver and renal function.
New Oxazolidines Inhibit the Secretion of IFN-γ and IL-17 by PBMCS from Moderate to Severe Asthmatic Patients
Authors: Santos Renata Virgínia Cavalcanti , Cunha Eudes Gustavo Constantino , de Mello Gabriela Souto Vieira , Rizzo José Ângelo , de Oliveira Jamerson Ferreira , do Carmo Alves de Lima Maria , da Rocha Pitta Ivan , da Rocha Pitta Maira Galdino , de Melo Rêgo Moacyr Jesus Barreto 
Published: September 2020

Background:
Moderate to severe asthma could be induced by diverse proinflammatory
cytokines, as IL-17 and IFN-γ, which are also related to treatment resistance and airway hyperresponsiveness.
Oxazolidines emerged as a novel approach for asthma treatment, since some chemical peculiarities
were suggested by previous studies.

Objective:
The present study aimed to evaluate the IL-17A and IFN-γ modulatory effect of two new
oxazolidine derivatives (LPSF/NB-12 and -13) on mononucleated cells of patients with moderate and
severe asthma.

Methods:
The study first looked at potential targets for oxazolidine derivatives using SWISS-ADME.
After the synthesis of the compounds, cytotoxicity and cytokine levels were analyzed.

Results:
We demonstrated that LPSF/NB-12 and -13 reduced IFN-γ and IL-17 production in peripheral
blood mononucleated cells from asthmatic patients in a concentrated manner. Our in silico analysis
showed the neurokinin-1 receptor as a common target for both compounds, which is responsible
for diverse proinflammatory effects of moderate and severe asthma.

Conclusion:
The work demonstrated a novel approach against asthma, which deserves further studies
of its mechanisms of action.
Acute Neurological Manifestations of Porphyrias and its Types: A Systematic- Review
Authors: Barletta Enrico A. , Belsuzarri Telmo A. B. , Urena Augusto R. B. , Iunes Eduardo A. 
Published: September 2020

Introduction:
Acute porphyrias cause life-threatening attacks of neurovisceral non-specific
symptoms, so this condition mimics many acute medical and psychiatric diseases. The disease
is very misdiagnosed, probably due to its low incidence and non-pathognomonic symptoms, this delays
the effective treatment onset. Early diagnosis and treatment highly improve the prognosis and
can prevent the development of neuropathic manifestations.

Methods:
We assembled a systematic review, following the PRISMA guidelines and using
Pubmed as our database. Our aim was to show some peculiarities among patients that present neurological
manifestations in acute porphyria attack. We obtained the patients’ age, sex, clinical presentation,
eurological manifestations and porphyria type of 16 patients. We also evaluated the time
between symptoms onset and neurological manifestations. The average age was 28,4 ± 11,1; 50%
of patients were male.

Results:
AIP was the most prevalent porphyria type. The average time between symptoms onset
and neurological manifestations was of 9,53 ± 11,6 days. Abdominal pain; nausea and vomiting
and psychiatric manifestations were the most common symptoms preceding neurological attacks.
Seizures and consciousness disturbance were the most prevalent findings within an attack. We also
presenting a case to illustrate how difficult this diagnosis can be.
Molecular Evaluation of HIF-1α Gene Variation and Determination of Its Frequency and Association with Breast Cancer Susceptibility in Saudi Arabia
Authors: Mir Rashid , Abu-Duhier Faisel M. , Albalawi Ibrahim A. 
Published: September 2020

Aim:
Hypoxia-inducible factor 1 (HIF-1α) is responsible in regulating oxygen homeostasis
in tissues and is a central effector of the hypoxic response besides its protein overexpression has been
shown to have prognostic relevance in several cancers including breast cancer. Several reports indicated
that HIF-1α gene variation C1772T (Pro582Ser) is associated with increased breast susceptibility
but results remained controversial. Therefore, we performed the molecular evaluation of HIF-1α gene
variation and determined its frequency and association with Breast Cancer susceptibility in Saudi Arabia.

Methods:
This study was conducted on histologically confirmed Breast cancer patients and gender
matched healthy women. HIF-1α C1772T (Pro582Ser) genotyping was done by Amplification refractory
mutation system PCR method. The HIF-1α gene genotypes were correlated with different clinicopathological
characteristics of breast cancer patients.

Results:
A significant difference was observed in genotype distribution of HIF-1α gene variation
C1772T (Pro582Ser) between breast cancer cases and gender matched healthy controls (P=0.010). Our
findings showed that the HIF- 1α variant was associated with an increased risk of Breast cancer for
HIF-1α CC vs CT genotype OR = 2.20, 95% CI = (1.28 -3.77), P = 0.004) in codominant inheritance
model. The significant association was reported for HIF1A for genotypes CC vs (CT+ TT) OR = 1.98,
95% CI = (1.17-3.34), P = 0.010) in dominant inheritance model tested. In case of recessive inheritance
model, a non-significant association of HIF-1 alpha gene variants was reported for (CC+ CT) vs
TT) OR = 1.03, 95% CI = (0. 064-16.79), P = 0.97). During the allelic comparison, a non-significant
association was reported between A vs C allele among Breast cancer patients. A significant association
of HIF- 1α polymorphism was reported with stage as well as distant metastasis of the disease.

Conclusion:
A significant difference was observed in genotype distribution of HIF-1α gene variation
C1772T (Pro>Ser) between breast cancer cases and gene matched healthy controls (P=0.010). HIF-1α-
CT heterozygosity and CC genotype increased the susceptibility .The HIF-1α polymorphism was reported
to be significantly associated with the distant metastasis of Breast cancer. Further studies with
larger data set and well-designed models are required to validate our findings.
Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women
Authors: Arslan Habibe S. , Nursal Ayse F. , Inanir Ahmet , Karakus Nevin , Yigit Serbulent 
Published: September 2020

Background:
Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal
pain. It is more common in women than in men, and sex hormones may play a role in
this predominance. Therefore, this research investigated the clinical findings among Turkish females
and whether Estrogen-α (ESR1) gene variants are associated with FMS.

Methods:
A total of 219 individuals were enrolled in this study. ESR1 variants (PvuII/XbaI) were
genotyped using PCR-RFLP methods. The results of the analyses were evaluated for statistical significance.

Results:
There was a significant association between the ESR1 PvuII and FMS risk among Turkish
women. The ESR1 PvuII CC genotype and C allele were higher in the patients than those in the
controls (p=0.021, p=0.007, respectively). A more statistically significant association was observed
between the patients and the controls in terms of TT genotype vs. TC+CC genotypes
(p=0.022). Also, there was a statistically significant association between the patients and the controls
in terms of TT+TC genotype vs. CC genotypes (p =0.028). There was no significant association
between patients and the control group concerning the genotype distribution and allele frequencies
of ESR1 XbaI (p>0.05). Headache was seen more frequently in the XbaI GA genotype
(p=0.025), while XbaI AA genotype was associated with dysmenorrhea in patients with FMS
(p=0.041).

Conclusion:
Our results indicate that ESR1 PvuII/XbaI variants are possibly effective in the development
of FMS and some clinical features.
Jeremia 52: Oordeel en hoop
Authors: De Waard H. 
Published: September 2020

This article examines the place and function of Jeremiah 52 in the book of Jeremiah, with a focus on the Masoretic text. It argues that the first part of Jeremiah 52, which describes the 587 BC fall of Jerusalem, shows how Jeremiah’s judgment oracles were fulfilled—pre-exilic Judah collapsed completely. The second part of the chapter, which describes the 561 BC release of King Jehoiachin, alludes to the book’s prophecies of hope for the exilic community in Babylon. From a biblical-theological perspective, this hope was partially realized in post-exilic Yehud; it has found and will find its full realization in the work of Christ.
Awareness and response to Coronavirus Disease (Covid-19) epidemic among the Arab population in the Eastern Mediterranean Region and Arab Peninsula
Authors: Saleh Mhammad , Saleh Marwan , Zahid Mohammed Nabil 
Published: September 2020

Objectives: This online survey planned to analyze the knowledge and apprehension about coronavirus among the Arab populations.
Methods: a cross-sectional questionnaire-based survey was conducted from 15th May 2020 to 27th May 2020. The survey included a total of 443 Arab participants. Divided into four groups according to the age; under 20 years old (28 participants), 20- 40 (359), 40- 60 (49), and 7 participants were over 60. According to gender; male (318 participants) and female (125). Based on education level, participants were categorized as a secondary school (5 participants), high school (28), university graduated (327), and postgraduate (83).
Results: Most of the participants showed a good adaptation for the precautions concerning isolation and quarantine. 299 participants stayed at home during the COVID-19 outbreak by taking a break from jobs or performing their jobs from home. 144 participants performed partial or full-time jobs from 20-60 groups of age. Most of the population were dependent on social media to receive the update about the virus. 141 participants said that they are not up to date enough about the COVID-19 related to the language barrier.
Conclusion: The majority of the participants had heard about COVID-19 and were aware of the infection control measures. Most of the participants strictly adapted to quarantine during the outbreak. Further steps need to be taken to enhance the social media accounts and internet websites in the Arabic language which concern medical and educational content.