bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cotrimoxazole Prophylaxis is Not Associated with a Higher Occurrence of Atazanavir Treatment Failure: Analysis of Worldwide Pharmacovigilance Data
Authors: Basilua Joe Miantezila , Pochart Philippe 
Published: December 2019

Background:
Cotrimoxazole is the main antibiotic used in HIV-infected patients for
the prophylaxis of opportunistic infections. This antibiotic is prescribed in patients receiving
antiretroviral agents (ART) such as Atazanavir (ATV), a protease inhibitor used with other ART
classes.

:
The objective of this study was to compare HIV treatment failure (HIVTF) in HIV-infected patients
treated concomitantly with ATV and cotrimoxazole to those of patients treated only with
ATV.

Materials and Methods:
This is a comparative analysis of the safety data of HIVTF available with
ATV in the WHO International Pharmacovigilance database "VigiBase®". We used the SMQ
(Standardized MedDRA Querie) to identify all the terms corresponding to HIVTF. We presented
results as a percentage or an adjusted Reporting Odds Ratio (aROR) with a 95% confidence interval
(95% CI).

Results:
A total of 116 cases of HIVTF (2.2%) were reported with ATV among the 5196 individual
case safety reports (ICSR) included in the analysis. The proportion of HIV-infected patients
who presented ATV treatment failure (ATVTF) was lower (2.6%, 3/116) when cotrimoxazole was
concomitant (aROR was 0.5 with a 95%CI from 0.2 to 1.7). Only 10 of 273 ICSRs (3.7%) were
reported from Africa concerning the use of cotrimoxazole prophylaxis concomitantly with ATV.

Conclusion:
This study did not show a higher occurrence of ATVTF when cotrimoxazole was
concomitant. These results reinforce the place of concomitant use of ATV with cotrimoxazole in
the management of HIV treatment.
Plasma Cytokine Levels in Overweight Versus Obese Disease-Free Perimenopausal Women
Authors: Maniçoba Anna C.B.N. , Galvão-Moreira Leonardo V. , D'Albuquerque Izabella M.S.C. , Brito Haissa O. , do Nascimento Johnny R. , do Nascimento Flávia R.F. , do C.L. Barbosa Maria , da Costa Rui M.G. , do D.S.B. Nascimento Maria , dos S. Faria Manuel , Brito Luciane M.O. 
Published: December 2019

Objective:
To evaluate the plasma cytokine levels during T cell-mediated inflammatory
responses and compare the metabolic markers between overweight and obese perimenopausal women
without systemic diseases.

Methods:
Sixty perimenopausal women were divided into two groups (overweight and obese). Participants
in both groups had their waist-to-height ratio (WHtR) measured and blood samples collected for
the evaluation of estradiol, fasting glucose, leptin, high-sensitivity C-reactive protein (hs-CRP), interleukin
(IL)-6, IL-10, IL-17A levels, and lipid profile.

Results:
In univariate analysis, women with obesity showed increased WHtR, fasting glucose, leptin,
and IL-6 (p < 0.05) levels; however, significant differences were not observed in IL-10 or IL-17A (p >
0.05) levels. In the receiver operating characteristic curve, the highest areas under the curve were
shown for leptin (0.856) and IL-6 (0.706). IL-6 levels correlated with both hs-CRP (r = 0.302, p =
0.020) and leptin (r = 0.294, p = 0.022). However, in multivariate analysis, IL-6 was not associated
with a greater likelihood of obesity (OR = 1.61; 95% CI: 0.82-3.15; p = 0.16), when potential confounders
were considered.

Conclusion:
IL-6 levels varied between overweight and obese perimenopausal women, and this association
was weaker when adjusted for other clinical variables.
Advancing Internationalization at Home from Different Roles
Authors: Baumvol Laura 
Published: December 2019

The SFU Ed Review Journal interviewed Dr. Jos Beelen for this Special Issue on Internationalization of Higher Education. The interview was conducted via video by Dr. Laura Baumvol.
Dr. Beelen is Professor of Global Learning at The Hague University of Applied Sciences. He leads a research group that explores internationalisation at home, particularly the skills of lecturers to develop and teach internationalised curricula. Action research is a key method for this research theme. Another research theme is the continuum of internationalisation, from primary to tertiary education. Jos has published a range of articles on the implementation of internationalisation at home, both from educational and organisational, systemic, perspectives.
Dr. Beelen is also a Visiting Professor at Coventry University and a senior trainer for the European Association for International Education (EAIE). From that association he was the recipient of the 2018 President’s Award for his contribution to internationalisation at home.
Identifying and Overcoming Policy-Level Barriers to the Implementation of Digital Health Innovation: Qualitative Study
Authors: Desveaux Laura , Soobiah Charlene , Bhatia R Sacha , Shaw James 
Published: December 2019

BackgroundHigh-level policy barriers impede widespread adoption for even the most well-positioned innovations. Most of the work in this field assumes rather than analyzes the driving forces of health innovation. Objective: The aim of this study was to explore the challenges and opportunities experienced by health system stakeholders in the implementation of digital health innovation in Ontario.ObjectiveThe aim of this study was to explore the challenges and opportunities experienced by health system stakeholders in the implementation of digital health innovation in Ontario.MethodsWe completed semistructured interviews with 10 members of senior leadership across key organizations that are engaged in health care–related digital health activities. Data were analyzed using qualitative description.ResultsA total of 6 key policy priorities emerged, including the need for (1) a system-level definition of innovation, (2) a clear overarching mission, and (3) clearly defined organizational roles. Operationally, there is a need to (4) standardize processes, (5) shift the emphasis to change management, and (6) align funding structures.ConclusionsThese findings emphasize the critical role of the government in developing a vision and creating the foundation upon which innovation activities will be modeled.
Making Meaning of Historical Papua New Guinea Recordings
Authors: Harris Amanda , Gagau Steven , Kell Jodie , Thieberger Nick , Ward Nick 
Published: December 2019

PARADISEC’s PNG collections represent the great diversity in the regions and languages of PNG. In 2016 and 2017, in recognition of the value of PARADISEC’s collections, ANDS (the Australian National Data Service) provided funding for us to concentrate efforts on enhancing the metadata that describes our Papua New Guinea (PNG) collections, an effort designed to maximise the findability and useability of the language and music recordings preserved in the archive for both source communities and researchers. PARADISEC's subsequent engagement with PNG language experts has led to collaborations with members of speaker communities who are part of the PNG diaspora in Australia. In this paper, we show that making historical recordings more findable, accessible and better described can result in meaningful interactions with and responses to the data in source communities. The effects of empowering speaker communities in their relationships to archives can be far reaching – even inverting, or disrupting the power relationships that have resulted from the colonial histories in which archives are embedded.
Could We Derive Benefit From Implementing Electronic Medical Records In Hospital?: A Structured Evidence and Narrative Review
Authors: Rahmawati Sarah Rosiana 
Published: December 2019

Introduction
One method chosen by many hospitals to achieve efficiency is the use of an Electronic Medical Record (EMR) system. This study discusses the EMR and its relationship with the efficiency and quality of hospital services through patient outcomes and users’ (physicians’ and nurses’) perspectives.
Method
A structured evidence and narrative review using the PRISMA method, with articles retrieved from online databases including PubMed, Wiley, ScienceDirect and ProQuest. The study’s period of review dates back ten years.
Results
The advantages of EMRs are decreased length of stay (LOS) and infection rate, plus a reduced probability of readmission once a patient safety event has occurred. EMRs reduce nurse, licensed vocational nurse (LVN) and registry cost per hour. EMRs provide enhanced ability in completing medical records and clinical documentation. The disadvantages are greater inefficiency in medical-surgical acute settings and increased cost per patient day. EMR does not reduce LOS in ICU. Some physicians also complain about the inefficiencies and time loss created by EMR.
Conclusion
The implementation of EMR in hospitals has advantages and disadvantages. Hospital management should undertake more analysis and consideration prior to deciding whether or not to use EMR.
Keywords: Electronic medical records, hospital, patients’ outcomes, efficiency
A Conservative Approach to Ceramic Veneers: A Case Report
Authors: Jurado C , Watanabe H , Tinoco J Villalobos , Valenzuela H Ureta , Perez G Guzman , Tsujimoto A 
Published: December 2019

SUMMARYBonding to enamel has been shown to provide reliable results, and thus conservative tooth preparations are key to the success of ceramic bonded restorations. The wax-up is the first diagnostic tool available to evaluate discrepancies between current and ideal tooth proportions. The clinician's diagnostic mock-up provides the patient with a visual perception of the size and shape of the proposed restorations. The use of reduction guides assists the restorative dentist in evaluating the specific amount of tooth structure to be removed during preparation. Furthermore, total isolation with a rubber dam prior to bonding the final restorations is crucial for the success of adhesive protocols. The aim of this report is to demonstrate a conservative approach to tooth preparation with a complete isolation technique prior to bonding eight ceramic restorations.
CURRÍCULO E CONSTRUÇÃO DE UM COMUM: ARTICULAÇÕES INSURGENTES EM UMA POLITICA INSTITUCIONAL DE FORMAÇÃO DOCENTE
Authors: Gabriel Carmen Teresa 
Published: December 2019

Este texto tem por objetivo explorar o potencial político e analítico do significante “comum” na reflexão curricular contemporânea a partir da análise de uma política institucional de formação inicial e continuada de professores em desenvolvimento em uma universidade pública federal. Para tal opero com as teorizações pós-estruturalistas, em particular as que se inscrevem na abordagem pós-fundacional como defendida por Olivier Marchart para a compreensão e posicionamento nos debates em torno das politicas que mobilizam fluxos de sentido de currículos de licenciatura e dos currículos escolares. Trata-se, mais particularmente, de focalizar, nessas políticas, os processos de significação que mobilizam o significante “comum” traduzindo os diferentes interesses em jogo. Em diálogo com as contribuições teóricas de Pierre Dardot e Christian Laval e na contramão das interpretações recentes produzidas no campo do Currículo sobre os sentidos e mobilizações desse termo, proponho uma leitura outra, produtiva do significante “comum”. Na perspectiva aqui privilegiada a ideia de construção de um comum se apresenta como possibilidade de politizar o campo superando binarismos e reconhecendo a força e o papel crucial da contingencia nessas disputas. O artigo apresenta, primeiramente, alguns usos do comum que vêm sendo hegemonizados nos estudos curriculares, bem como interpretações outras possíveis e disponíveis. Em seguida, tendo como campo empírico uma politica curricular em curso, sublinha a potência heurística de um entendimento de comum que tem orientado a sua operacionalização e funcionado como verdadeira insurreição ou rede de resistência inventiva em tempos de desmonte do sistema publico educacional em nosso país.
As contribuições do Pibid para uma formação crítica e social do professor: a experiência da Universidade Regional do Cariri (Urca)
Authors: Paula Oliveira Francisca Clara de , Bertino Algebaile Eveline 
Published: December 2019

O artigo tem como objetivo refletir acerca das contribuições do Programa Institucional de Bolsas de Iniciação à Docência (Pibid) para a formação crítica e social do professor. As questões discutidas referem-se ao papel do programa nos cursos de licenciatura da Universidade Regional do Cariri (Urca). Os dados foram coletados por meio de pesquisa documental e bibliográfica. Os resultados apontam que o Pibid se constituiu uma experiência significativa para os cursos de formação de professores da IES ao sintonizá-los com os problemas da escola básica da região, fortaleceu uma nova concepção de ensino desses cursos e deu mais visibilidade à educação básica no processo de pensar e fazer a formação docente. Constatou-se que o programa trouxe uma aproximação mais qualitativa e permanente da universidade com a escola, o que permitiu que professores e estudantes pensassem e agissem juntos no cenário da educação escolar local, desenvolvendo atividades embasadas nas problemáticas específicas.
Elaboration of triplex PCR for detection of selected viral infections in waterfowl
Authors: Kozdruń Wojciech , Czekaj Hanna , Styś-Fijoł Natalia , Piekarska Karolina , Samanta Niczyporuk Jowita 
Published: December 2019

Abstract

Introduction
Viral infections are the greatest threat to waterfowl and cause significant economic losses. Diagnosis and differentiation of three goose viruses is difficult in the field and often requires laboratory confirmation. Therefore, the aim of the study was to develop a triplex PCR and optimise its parameters for simultaneous detection of DNA of goose parvovirus (GPV), goose polyomavirus (GHPV), and goose circovirus (GoCV).

Material and Methods
The DNA of viruses isolated from field cases from the National Veterinary Research Institute’s own collection was used for the study. The primer attachment temperature, the number of reaction cycles, and the Taq DNA polymerase and Mg2+ concentrations were optimised. The sensitivity and specificity of this triplex PCR was also determined.

Results
Based on the obtained results, triplex PCR parameters were optimised for simultaneous detection of DNA of GPV, GHPV, and GoCV in one sample. The following PCR products of the expected size were obtained: GPV DNA of 806 bp, GoCV DNA of 571 bp, and GHPV DNA of 180 bp.

Conclusion
The developed triplex PCR method proved to be useful for simultaneous detection of infections with three waterfowl viruses and will be used in relevant laboratory diagnostics.
Characterization of patients with pre-diabetes in first-level health care service institutions Cali, Colombia
Authors: Figueroa Fabio N , Morales Jessica , Melgarejo Aralí , Forero Jousetp , Motoa Gabriel , León Jaime A , Londoño Andrés . C , Salazar Blanca C 
Published: December 2019

Introduction: Type 2 diabetes (DM 2) is one of the first ten causes of mortality in Colombia. Pre-diabetes is a state of hyperglycemia that associated with other risk factors appears 5-10 years before this disease. It has been reported that controlling the diet and exercise decreases the probability of suffering DM 2 by 60%. This intervention requires establishing the risk in pre-diabetic patients. Objectives: To detect patients with pre-diabetes who are members of a private health care provider (EPS for its name in Spanish) in Cali and to describe the clinical and epidemiological characteristics related to the risk of developing DM 2. Materials and methods: This is a cross-sectional descriptive study in patients with altered glucemias (Impaired fasting glucose: 100-125 mg/dl and impaired glucose tolerance: 140-199 mg/dl). Clinical histories were reviewed and surveys on risk factors, habits and perception of knowledge were conducted. We determined: fasting glucose, vital signs, and anthropometric measures. Results: 111 patients were included (64% women) whose most common occupation was home duties (39.6%). The descriptive analysis reported high risk; the results were: noticeable presence of associate pathological antecedents as follows: Diabetes in the family (64%), obesity (54.1%), dyslipidemia (72.1%), and hypertension (66.7%) in a population with a mean age at 51 years and 10.8% were under 40 years of age. This great proportion of overweight or obesity (86.5%), according to BMI, influenced the determination of the high cardio-metabolic risk (81%, agreeing with the WHO). When evaluating diet with consumption frequency, we still found the intake of simple carbohydrates and animal fats; when reviewing physical activity, 53.2% of the patients reported activity in the last 7 days according to the International Physical Activity Questionnaire (IPAQ). Conclusions: 66% of pre-diabetics did not have diagnosis of some disorder of the metabolism of carbohydrates. More than 70% of the patients have high risk of DM 2 with pathological antecedents, inadequate health habits, and low perception of disease complications.
Bordetella pertussis infection in household contacts of cases of pertussis in the southeast zone of the city of Cali, Colombia, 2006-2007
Authors: Astudillo Miryam , Estrada Victoria Eugenia , Fernández de Soto Mónica , Moreno Luz Ángela 
Published: December 2019

Introduction: Bordetella pertussis causes whooping cough or convulsive cough, a contagious and immune-preventable disease. It is one of the 10 leading causes of death among children younger than one year of age, when not completely immunized. It is considered reemerging in several countries, with high rates of complications and hospitalizations. Objective: to learn of the proportion of infection by B. pertussis among suspected cases of whooping cough and their household contacts among children from the southeast zone of Cali, a geographic area with great consultation demand due to this infection. Methodology: This is a cross-sectional descriptive study. Epidemiological data and nasopharyngeal samples were taken from 24 suspected cases and from their 109 household contacts. The samples were analyzed via real-time polymerase chain reaction (Q-PCR) and through culture. Results: The proportion of positivity among the cases via the Q-PCR technique was at 50% (12/24) and at 40% via the culture technique (8/20), with good agreement between both techniques (Kappa 0.61). Regarding the household contacts, 30.3% (33/109) (CI 95%: 21.8%-39.8%) tested positive. The sibling contacts (7/15) and the mothers (7/22) presented the greatest proportion of positivity. Regarding age, 60% were 4 years of age (3/5) and 50% were in the group comprised of individuals 45 to 64 years of age. No significant differences were found among the presence or absence of symptoms and the presence of B. pertussis infection, except for the presence of nasal secretions (runny nose) (27%) and coughing (36%) during the last month. Conclusions: The study confirms the high prevalence of asymptomatic infection by B. pertussis among household contacts of children with whooping cough symptomatology and its household transmission. In Cali, health authorities need to review the effectiveness of implemented control strategies and the use of a vaccination scheme that does not cover adolescent and adult populations as a focus of infection control.
Epidemiological analysis of 1404 patients with intracranial aneurysm followed in a single Brazilian institution
Authors: Júnior Jefferson Rosi , Telles João Paulo Mota , da Silva Saul Almeida , Iglesio Ricardo Ferrareto , Brigido Mauricio Mandel , Pereira Caldas José Guilherme Mendes , Teixeira Manoel Jacobsen , Figueiredo Eberval Gadelha 
Published: December 2019

Background:
We sought to evaluate the epidemiology of intracranial aneurysms in relation to location, gender, age, presence of multiple aneurysms, and comorbidities in the Brazilian population.

Methods:
We performed a prospective analysis of a cohort of 1404 patients diagnosed with intracranial aneurysm admitted to the Hospital das Clinicas of the University of Sao Paulo, a referral hospital for the treatment of cerebrovascular diseases in Brazil. Patients admitted between September 2009 and September 2018 with radiological diagnosis of intracranial aneurysm were included in the study.

Results:
A total of 2251 aneurysms were diagnosed. Females accounted for 1090 aneurysms (77.6%) and the mean age at diagnosis was 54.9 years (ranging 15–88). The most common location was middle cerebral artery (MCA) with 593 aneurysms (26.3%) followed by anterior cerebral artery (ACA) with 417 aneurysms (18.5%) and internal carotid artery in the posterior communicating segment with 405 aneurysms (18.0%). Males had higher rates of ACA aneurysms (29.7%) while females had higher rates of MCA aneurysms (26.1%). Sorting by size, 492 aneurysms were <5 mm (21.8%), 1524 measured 5–10 mm (67.7%), 119 size 11–24 mm (5.3%), and 116 were >24 mm (5.2%). The occurrence of multiple aneurysms was associated with female gender (P < 0.001) and smoking (P < 0.001), but not with hypertension (P = 0.121).

Conclusion:
In this population, the occurrence of intracranial aneurysm is related to several factors, including gender, age, smoking, and hypertension. Our study brought to light important characteristics of a large number of Brazilian patients regarding epidemiology, location, size, and multiplicity of intracranial aneurysms.
Hybrid nerve sheath tumor in the orbit: A case report and review of literature
Authors: Hong Sukwoo , Hara Takayuki 
Published: December 2019

Background:
In neurosurgical practice, we rarely encounter hybrid nerve sheath tumors (HNST) in the orbit. We recently had a patient of this rare tumor. We believe that this is the first report where we resected the tumor transcranially.

Case Description:
A 54-year-old male presented with the left proptosis and intraconal tumor of 43 mm. We performed fronto-orbital craniotomy to resect the tumor mass. His proptosis completely improved and discharged home with a modified Rankin Scale of 1.

Conclusion:
Transcranial resection of orbital HNST was a safe and effective way to treat. Since we do not have much data regarding this rare tumor, we need to accumulate more cases.
A 3D-printed Microfluidic System for Automated and Near Real-time Quantitation of Biofilm-induced indole
Authors: Kabandana Giraso , Jones Curtis G. , Sharifi Sahra Khan , Chen Chengpeng 
Published: December 2019

We developed a novel microfluidic system that enables automated and near real-time quantitation of indole release kinetics from biofilms.Now published at https://www.sciencedirect.com/science/article/pii/S0924424720311031
Pergerakan dan Pencucian Hara pada Tanah Typic Hapludult di Taman Nasional Bukit Duabelas: Hubungan Kation-anion
Authors: Putra Gilang Sukma , Hartono Arief , Anwar Syaiful , Murtilaksono Kukuh 
Published: December 2019

Soil Nutrient are dynamics. Their amount and movement within soil solution can determine its fertility to accomodate plant growth. The dissolved nutrients are moving together in the form of cations and anions. This study aims to determine the amount of dissolved cation-anion in the soil solution and to evaluate its relationship. Field trial was conducted at tropical rainforest of Bukit Duabelas National Park. The Lisymeter was installed on each Typic Hapludult soil horizon to accommodate percolated water. The leached water sample was extracted and each cation (NH4+, Ca2+, Mg2+, K+) and anion (PO43-, Cl-, SO42-, NO3-) concentration were measured. Data were analyzed using independent-t stastical test, Spearman correlation, and stepwise linear regression. The results show that the total amount of cation and anion are significantly higher in the AO horizon than the AB and B horizons. The correlation analysis results show that each cation has a strong correlation to each anion (correlation value > 0.80) except PO43- ( ~ 0.70). Stepwise linear regression model shows that NH4+ has the strongest relation to NO3-, PO43-, and Cl- with R2 adj.= 0.75, Ca2+ to NO3-, PO43-, and SO42- (R2 adj.= 0.856), Mg2+ to NO3- and PO43- (R2 adj.= 0.815), and K+ to PO43- and Cl- (R2 adj.= 0.845). It can be concluded that NO3-, Cl-, SO42-, and PO43- are directly involved as cation co-pairing agents in the soil nutrient movement and leaching process.