bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality in SLE patients compared with population controls in Finland in years 2000–2015
Authors: Elfving Pia , Kariniemi Simo , Kautiainen Hannu , Virta Lauri J , Kaipiainen-Seppänen Oili , Puolakka Kari 
Published: December 2020

Abstract

Objective
To estimate the risk of mortality in the Finnish incident SLE cohort in a 16-year period compared with the general population.

Methods
Adults with new-onset SLE between 1 January 2000 and 31 December 2014 identified from the national drug reimbursement register and their individually matched controls from the Population Register Centre were followed up until death or 31 December 2015. Data on deaths were retrieved from the national causes of death register. Comorbidities and education were obtained by linkage to the other national registries.

Results
A total of 1006 patients with incident SLE and 3005 population controls were found (mean follow-up 8.6 years). Of these, 98 SLE patients subsequently died. Their 5 -, 10-, and 15-year survival rates were 95.0% (95% CI: 93.3, 96.2), 88.8% (86.2, 91.0), and 82.1% (77.6, 85.8), respectively. Crude hazard ratio (HR) was 1.61 (95% CI: 1.26, 2.06), adjusted for education level was almost the same 1.61 (95% CI: 1.26, 2.05). After adjustment for comorbidities and education at baseline, the difference in mortality disappeared: HR 1.14 (95% CI: 0.88, 1.48). The leading causes of death were cardiovascular diseases (CVDs) (33%), malignancies (27%) and neurological diseases (10%). Subhazard ratio for CVD deaths was 1.28 (95% CI: 0.85, 1.93), adjusted for comorbidities and education 0.88 (95% CI: 0.56, 1.39).

Conclusions
These results suggest that the increased mortality in SLE patients is highly associated with comorbidities present at diagnosis. This underlines the importance to screen and treat comorbidities and disease actively without delays.
Crystal deposition measured with dual-energy computed tomography: association with mortality and cardiovascular risks in gout
Authors: Marty-Ané Anne , Norberciak Laurène , Andrès Mariano , Houvenagel Eric , Ducoulombier Vincent , Legrand Julie , Budzik Jean-François , Pascart Tristan 
Published: December 2020

Abstract

Objectives
To determine whether the volume of monosodium urate (MSU) crystal deposition measured with dual-energy CT (DECT) is predictive of short-term mortality and development of cardiovascular comorbidities and diabetes mellitus.

Methods
Patients with a diagnosis of gout having had baseline DECT scans of their knees and feet to measure the volume of MSU crystal deposition were included to undergo a follow-up visit. Risk factors for mortality and a composite variable (onset of any cardio-metabolic event) were examined using multivariable Cox models.

Results
A total of 128 patients aged 66.1 (14.0) years with gout durations of 11.4 (10.4) years were included; most were naïve of urate lowering therapy (61.7%), with a follow-up visit at 24 (12, 36) months. Baseline serum urate (SU) level was 7.44 (2.29) mg/dl and DECT volume of MSU crystals was 0.2 (0, 0.9) cm3. A total of 14 patients died during follow-up, 6/14 from a cardiovascular cause, and 17 patients presented a new cardio-metabolic comorbidity. Factors associated with mortality risk were baseline DECT volume of MSU crystals [hazard ratio (HR) 1.02, 95% CI: 1.002, 1.03] and baseline SU level (HR 1.04, 95% CI: 1.003, 1.06). DECT volume of MSU crystals was the only factor associated with the onset of cardio-metabolic comorbidities with a HR of 1.014 (95% CI: 1.001, 1.03).

Conclusions
Volume of MSU crystals measured with DECT is a biomarker for the risk of developing new cardio-metabolic diseases and for all-cause mortality.
Metagenomics of black grains: new highlights in the understanding of eumycetoma
Authors: Santona Antonella , Mhmoud Najwa A , Siddig Emmanuel Edwar , Deligios Massimo , Fiamma Maura , Bakhiet Sahar Mubarak , Barac Aleksandra , Paglietti Bianca , Rubino Salvatore , Fahal Ahmed Hassan 
Published: December 2020

Abstract

Background
Eumycetoma is a chronic subcutaneous granulomatous disease that is endemic in Sudan and other countries. It can be caused by eight different fungal orders. The gold standard diagnostic test is culture, however, culture-independent methods such as imaging, histopathological and molecular techniques can support diagnosis, especially in cases of negative cultures.

Methods
The amplicon-based internal transcribed spacer 2 metagenomic technique was used to study black grains isolated from 14 tissue biopsies from patients with mycetoma. Furthermore, mycological culture and surgical biopsy histopathological examinations of grains were performed.

Results
Madurella mycetomatis (n=5) and Falciformispora spp. (n=4) organisms were identified by culture and confirmed by metagenomics. Metagenomics recognised, at the species level, Falciformispora as Falciformispora tompkinsii (n=3) and Falciformispora senegalensis (n=1), while in culture-negative cases (n=5), Madurella mycetomatis (n=3), Falciformispora senegalensis (n=1) and Fusarium spp. (n=1) were identified. Interestingly, the metagenomics results showed a ‘consortium’ of different fungi in each sample, mainly Ascomycota phylum, including various species associated with eumycetoma. The microbial co-occurrence in eumycetoma showed the co-presence of Madurella with Trichoderma, Chaetomium, Malasseziales and Sordariales spp., while Falciformispora co-presented with Inocybe and Alternaria and was in mutual exclusion with Subramaniula, Aspergillus and Trichothecium.

Conclusion
Metagenomics provides new insights into the aetiology of eumycetoma in samples with negative culture and into the diversity and complexity of grains mycobiota, calling into question the accuracy of traditional culture for the identification of causative agents.
Mycetoma imaging: the best practice
Authors: Bahar Mustafa Elnour , Bakheet Osama E L Hadi , Fahal Ahmed Hassan 
Published: December 2020

Abstract
Mycetoma is a recognised neglected tropical disease that for a long time has been accorded inadequate attention across the globe. It is a chronic destructive inflammatory disease caused by fungi (eumycetoma) or actinomycetes (actinomycetoma). Mycetoma treatment depends on an accurate and precise diagnosis. The cornerstone for proper disease diagnosis is identification of the causative organisms, but also critical for diagnosis and management planning is determination of its extent along and across tissue planes. An initial diagnosis is made after clinical assessment. Clinical examination alone does not identify the causative organism nor does it detect the spread of disease along the different tissue planes and bone. Imaging techniques, such as radiography, ultrasonography, computed tomography scan and magnetic resonance imaging can be used to determine the extent of lesions. In this communication, the Mycetoma Research Centre, World Health Organization Collaborating Centre on Mycetoma, University of Khartoum, presents its experience and recommendations on mycetoma diagnostic imaging.
Methyldopa Versus Nifedipine or No Medication for Treatment of Chronic Hypertension During Pregnancy: A Multicenter Randomized Clinical Trial
Authors: Salama Mohamed , Rezk Mohamed , Gaber Wael , Hamza Haitham , Marawan Hala , Gamal Awni , Abdallah Sameh 
Published: December 2020

(Abstracted from Pregnancy Hypertens 2019;17:54–58)
Pregnant women with chronic hypertension are at increased risk of pregnancy complications. Yet, it is unclear whether antihypertensive treatments lower the risks of maternal morbidity and mortality.
Lidocaine Use in Vaginal Surgery and Risk of Toxicity
Authors: Willis-Gray Marcella G. , Husk Katherine E. , Brueseke Taylor J. , Connolly AnnaMarie , Geller Elizabeth J. 
Published: December 2020

(Abstracted from Female Pelvic Med Reconstr Surg 2020;26:546–549)
Intravenous (IV) lidocaine is often given by anesthesiologists during induction of anesthesia to reduce pain caused by the injection of propofol. Although useful during surgery, local anesthetics are not without risks.
Huanglian Jiedu Decoction for treatment of multiple myeloma
Authors: An Na , Li Yiwei , Huang Xilian , Chen Can , Xie Yaping 
Published: December 2020

Abstract

Background:
Multiple myeloma can lead to lots of clinical problems including pain, fatigue, anemia, infections, renal failure, and so on. Huanglian Jiedu Decoction is a common conservative treatment for this disease in China. Therefore, we conducted a systematic review and meta-analysis to explore the efficacy of Huanglian Jiedu Decoction in the treatment of multiple myeloma.

Methods:
A systematic literature search for studies will be performed in 8 databases, including PubMed, Web of Science, Embase, the Cochrane library, ClinicalTrials.gov databases, Chinese National Knowledge Infrastructure Database, Wanfang database, and VIP database. The methodological quality of the included studies using the risk bias assessment tool of Cochrane. And the level of evidence for results is assessed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. Statistical analysis is conducted with Revman 5.3.

Results:
This systematic review and meta-analysis will provide a synthesis of existed evidences for Huanglian Jiedu Decoction on multiple myeloma.

Conclusion:
The conclusion of this study will provide evidence to assess effectiveness of Huanglian Jiedu Decoction on multiple myeloma, which can further guide clinical decision-making.

INPLASY registration number:
INPLASY202060094
Quantitative assessment-based nursing intervention improves bowel function in patients with neurogenic bowel dysfunction after spinal cord injury
Authors: Yin Qionghua , Wang Can , Yu Jianhong , Zhang Qiufang 
Published: December 2020

Abstract

Background:
The neurogenic bowel dysfunction is a kind of familiar sequelae of the spinal cord injury (SCI), occurring in 70 to 80 percent of the SCI patients. The nursing intervention based on quantitative evaluation is to fully consider and assess the disease condition of patients, implement the personalized programs of nursing intervention, meet the patient's nursing needs to the maximum extent, improve the quality of nursing, and then facilitate the rehabilitation of patients. Our aim is to implement this program to evaluate the impact of this nursing intervention based on quantitative evaluation on the quality of life and bowel function in the neurogenic bowel dysfunction patients after SCI.

Methods:
The experiment is a randomized clinical research which will be implemented from May 2021 to October 2021 at the First Affiliated Hospital of Soochow University. The experiment was granted through the Research Ethics Committee of the First Affiliated Hospital of Soochow University (No.100238765). Fifty neurogenic bowel dysfunction patients after SCI confirmed via the imaging are included in this study. The patients with the history of bowel diseases or patients who are unwilling to cooperate with the evaluation will be excluded. The primary outcomes are bowel function recovery and satisfaction of the patients. The secondary outcomes are quality of life evaluated by SF-36 questionnaire. The questionnaire involves physical pain, role physiology, physiological functions, social functions, vitality, general health, mental health and role-motional.

Results:
Comparison of clinical parameters between the 2 groups will be shown in Table 1.

Conclusion:
Nursing intervention based on the quantitative evaluation can improve the quality of life and recovery of intestinal function for the neurogenic intestinal dysfunction patients after SCI.

Trial registration number:
researchregistry6143
Analysis of factors and corresponding interactions influencing clinical management assistant ability using competency model in China
Authors: Zheng Xin , Shi Jia , Wu Jinyi 
Published: December 2020

Abstract
The clinical management assistant (CMA) is an innovative and practical way to help manage a hospital, so the selection of CMA is important. This research is to find the influencing factors on the competency of CMA and help to select proper candidate of CMA.
Based on the items of competency theory using the structural equation model, the data of 600 hospital managers from Shanghai, Guangzhou and Wuhan were identified by exploratory factor analysis and confirmatory factor analysis. In further analysis, the interactions among the factors were evaluated.
A total of 20 items were identified as critical to CMA capability, which were further tested and divided into 3 factors: (1) personal characteristics; (2) competence; (3) thinking. The subsequent analysis showed that all factors had significant impact on CMA's ability, and competence contributed the most to the formation of CMA's ability, while the intermediary role of personal characteristics and thinking could not be ignored in practice. The results showed that the competency model contained these 3 factors and had the same structure as the classic competency model.
This study presented a tentative approach for assessing CMA's competency, as well as provided the criteria to find and evaluate a CMA.
Efficacy of different plant extracts in the prevention of radiation dermatitis in radiotherapy patients with nasopharyngeal carcinoma
Authors: Yi Yi , You Xingli , Long Ying , Huang Ya 
Published: December 2020

Abstract

Background:
Radiation dermatitis is a common complication in patients with nasopharyngeal carcinoma (NPC) when treated with radiotherapy. Plant extracts have good effects on the prevention of radiation dermatitis in patients with NPC when treated with radiotherapy. However, there is insufficient comparison among the currently used plant extracts. Therefore, the purpose of this study was to explore the efficacy of different plant extracts in the prevention of radiation dermatitis in patients with NPC by Bayesian network meta-analysis.

Methods:
We searched Chinese and English databases to collect all randomized controlled trials (RCT) of plant extracts for the prevention of radiation dermatitis in NPC patients who underwent radiotherapy up to October 2020. Two researchers then independently screened articles, extracted data and evaluated the quality selected literatures. All data were processed by Stata 14.0 and WinBUGS V.1.4.3.

Results:
We applied Bayesian statistical model for network meta-analysis, ranked the effects of various plant extracts, and adopted GRADE method to explain the results.

Conclusion:
Our study is expected to provide high-quality evidence-based medicine advice for the prevention of radiation dermatitis in patients suffering from NPC undergoing radiotherapy.

Ethics and dissemination:
Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and will be shared on social media platforms. This review would be disseminated in a peer-reviewed journal or conference presentations.

OSF REGISTRATION NUMBER:
DOI 10.17605/OSF.IO/6SV45.
Relationship between long non-coding RNA and prognosis of patients with coronary heart disease after percutaneous coronary intervention
Authors: Wang Fei , Cai Xiaoqing , Jiao Piqi , Liu Yan , Yuan Bin , Zhang Peng , Liu Hongbin , Ma Ling 
Published: December 2020

Abstract

Background:
Long non-coding RNA (lncRNA) can predict the prognosis of patients with coronary heart disease (CHD) after obtaining percutaneous coronary intervention (PCI), while this conclusion still needs to be further confirmed. Therefore, this study attempted to explore the relationship between lncRNA and prognosis in CHD patients after PCI.

Methods:
The database was retrieved from China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database, PubMed, and EMBASE. Hazard ratios (HRs) and its 95% confidence interval (CIs) were applied to assess the prognostic effects of lncRNA on overall survival (OS). RevMan 5.3 and STATA 16.0 software were used to perform meta-analysis.

Results:
The results of this meta-analysis would be submitted to peer-reviewed journals for publication.

Conclusion:
This review provided a comprehensive overview of the relationship between lncRNA and prognosis in CHD patients after PCI, and offered recommendations for clinical practices or guidelines.
Platinum versus immunotherapy for unresectable esophageal cancer
Authors: Qian Jiekun , Tong Zhangwei , Zhang Yannan , Chen Chun 
Published: December 2020

Abstract

Background:
Esophageal cancer is one of the most common malignant tumors, with early metastasis, highly malignant characteristics. Morbidity ranks 7th among all malignant tumors, and mortality ranks 6th. Esophageal adjuvant therapy can significantly improve overall survival in unresectable esophageal cancer patients. With the breakthrough and progress of immunotherapy, the possibility of curing esophageal cancer has greatly increased. Some clinical trials have reported that compared with traditional platinum-based chemotherapy, the use of programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors alone can benefit patients and effectively prolong their overall survival. We compare the efficacy of single immunotherapy with traditional platinum-based chemotherapy in a systematic review and meta-analysis to provide a reliable basis for clinicians.

Methods:
We will search PubMed, Medline, Embase, Web of Science, Cancerlit, Google Scholar, and the Cochrane Central Register of Controlled Trials for related studies published before December 1, 2019 without language restrictions. Two review authors will search and assess relevant studies independently. Randomized controlled trials (RCTs) or quasi-RCTs, and prospective cohort studies will be included. We will perform subgroup analysis in sex, age, ethnicity, and tumor stage of esophageal cancer patients.

Results:
The results of this study will be published in a peer-reviewed journal.

Conclusion:
The results of this systematic review and meta-analysis will provide a basis for clinicians to formulate the best chemotherapy regimen for patients, as well as a research clue for clinical researchers in this field. The results of this study will expand the treatment options for esophageal patients, but due to the nature of the disease and intervention, large sample clinical trials are not abundant, so we will include some high-quality small sample trials, which may cause high heterogeneity.

INPLASY registration number:
INPLASY2020110012.
Efficacy and safety of massage in the treatment of post-stroke insomnia
Authors: Zhang Yajing , He Xingwei , Hu Shasha , Hu Songfeng , He Fan , Shen Yu , Zhao Fenfen , Zhang Qin , Liu Tingping , Wang Changkang 
Published: December 2020

AbstractBackground: Post-stroke insomnia (PSI) is a serious problem which has significant adverse effects on the subsequent recovery of patients and the quality of their daily life. Massage is effective in improving the quality of sleep for stroke patients displaying no significant adverse reactions. Up to now, however, there are still no systematic studies conducted to provide compelling evidence for its effectiveness in treating PSI. Allowing for this, this project is purposed to make a thorough summary of the efficacy of massage therapy in treating PSI and the safety of this practice.Methods: Without considering the status of publication and language, a meticulous search will be conducted, covering the Web of Science, the Cochrane Library search, PubMed, EMBASE, Chinese biomedical literature database, Chongqing VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang. All randomized controlled trials of PSI will be retrieved. The deadline is set as October 23, 2020. The team will be comprised of 2 experienced researchers who will apply RevMan V.5.3 software to conduct literature selection, data collection, data analysis, and data synthesis, respectively. In addition, the Cochrane risk Assessment tool will be taken as the top choice to evaluate the quality of the trials involved in this study.Results: The effectiveness and safety of massage therapy intended for PSI will be subject to a systematic evaluation under this program.Conclusion: It will be substantiated in this review whether massage therapy is a reliable intervention for PSI by examining the evidence collected.
Effects of houttuynia cordata thunb. on rhinosinusitis by nasal irrigation
Authors: Wang Dandan , Tian Tian , Liao Chao , Liu Ting , Tang Guangjun , Tian Li 
Published: December 2020

Abstract

Background:
The herba Houttuynia cordata Thunb. (HC) has anti-inflammatory, antibacterial and antiviral effects. Through nasal irrigation, the related preparation of HC is beneficial for treating rhinosinusitis or promoting recovery after an endoscopic sinus surgery. However, it remains controversial whether nasal irrigation with HC preparation can provide evidence-based clinical benefits for rhinosinusitis patients.

Methods:
With reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), 8 databases are perused to perform a methodical investigation of nasal irrigation with HC preparation and health-related results amongst rhinosinusitis patients. The main research purpose is to determine the influence of PRISMA standards on medical results pertaining to rhinosinusitis patients, including quantitative symptom recording and effective rate. With reference to the Cochrane Handbook, quality assessment of qualified papers is conducted using the Cochrane Risk Assessment Tool.

Results:
The results will be publicised through a peer-reviewed journal publication.

Conclusion:
The results of the systematic review will summarise evidences for the efficacy of nasal irrigation with HC preparation in rhinosinusitis treatment.

Ethics and dissemination:
Since this study involves a methodical investigation of issued medical papers, ethical authorisation and informed patient consent are not necessary.