bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased expression of Insulin-like growth factor binding protein 3 and its death receptor in association with poor prognosis of the patients with gastric cancer
Authors: Ansari Amir , Gheysarzadeh Ali , Bakhtiari Hadi , Razavi Amirnader Emami , Siavoshi Akram , Mofid Mohammad Reza 
Published: February 2020

Abstract
Background: Gastric cancer (GC) as one of the most common cancers, serves as the third cause of cancer-related death. Insulin-like growth factor binding protein 3 (IGFBP-3) and its novel death receptor (IGFBP-3R) has been shown to have an anti-tumor effect however their prognostic values have not been elucidated yet. Methods: IGFBP-3 and IGFBP-3R expression were evaluated with quantitative real-time polymerase chain reaction and western blotting in patients with GC (N=68). The relationship between prognostic factors such as tumor stage, tumor grade, tumor size, metastases, and Overall Survival (OS) with IGFBP-3/IGFBP-3R expression was also assessed. Results: IGFBP-3 and its death receptor expression were determined as dialectic evidence. In the experimental procedure, IGFBP-3 and IGFBP-3R expression were reduced in tumor tissues significantly. We found that there was an association between the reduction of IGFBP-3 with lymph node metastasis and TMN staging ( P<0.001 ). In addition, IGFBP-3R expression was associated with tumor size ( P=0.004 ), lymph node metastasis ( P<0.001 ), differentiation ( P=0.002 ) and TNM classification ( P=0.005 ). Interestingly, we presented that the downregulation of IGFBP-3R was stage-dependent. In OS analysis, we offered that low levels of IGFBP-3R mRNA expression were unfavorable with survival rate (P=0.002 ). IGFBP-3 regardless of its relationship with some prognostic parameters, there was no significant relationship between IGFBP-3 and OS. Conclusion: The findings of this study showed that IGFBP-3R has the potential to be a new prognostic biomarker of GC. But despite some benefit of IGFBP-3, it cannot be accepted as a prognostic biomarker. However, this finding must be improved and confirmed by future studies.
Prediction of mechanical properties and fatigue life of nano silver paste in chip interconnection
Authors: Yang Hui , Wu Jihui 
Published: February 2020

Abstract
The simulation of nano-silver solder joints in flip-chips is performed by the finite element software ANSYS, and the stress-strain distribution results of the solder joints are displayed. In this simulation, the solder joints use Anand viscoplastic constitutive model, which can reasonably simulate the stress and strain of solder joints under thermal cycling load. At the same time this model has been embedded in ANSYS software, so it is more convenient to use. The final simulation results show that the areas where the maximum stresses and strains occur at the solder joints are mostly distributed in the contact areas between the solder joints and the copper pillars and at the solder joints. During the entire thermal cycling load process, the area where the maximum change in stress and strain occurs is always at the solder joint, and when the temperature changes, the temperature at the solder joint changes significantly. Based on comprehensive analysis, the relevant empirical correction calculation equation is used to calculate and predict the thermal fatigue life of nano-silver solder joints. The analysis results provide a reference for the application of nano-silver solder in the electronic packaging industry.
Geochemical composition of sapropel in lakes: reflections of paleoenvironmental conditions and anthropogenic influence
Authors: Satkūnas Jonas , Valskys Vaidotas , Ignatavičius Gytautas , Grigienė Alma 
Published: February 2020

Abstract
Geochemical and lithological parameters of sapropel in lakes, combined with pollen data and radiocarbon 14C datings, contain a wide spectrum of environmental information. This includes records of fluctuations of water level and changes of conditions of sedimentation, accumulation of organic matter and chemical elements due to climate change, human impacts and other environmental changes. Four lakes with different trophic states and anthropogenic pressures were chosen for this study in Lithuania. Lake Balsys has a mesotrophic state while Lakes Didžiulis, Salotė and Gineitiškės have eutrophic states. X-ray fluorescence spectrometry was used to analyse concentrations of chemical elements, loss-on-ignition to determine organic, mineral and carbonate matter, pollen analysis and radiocarbon dating were applied for determination of paleoenvironmental conditions and age of sediments. Results of this study demonstrated rather different chemical compositions of sapropels in these lakes. Human impacts are evident in the upper layers of sapropel in all lakes, however very specific and complex geochemical composition was determined in deeper layers of sapropel in the different lakes. Higher concentrations of elements like Cr and Zn are expected in deeper layers of sapropel and are attributed to lithogenic association of trace elements. Pb and Cu were detected in upper layers of sapropel which indicates the impact of anthropogenic activity. Sapropel of eutrophic lakes (Salotė and Gineitiškės) is enriched by high concentrations of heavy metals (galbūt naudoti tiesiog chemical elements?) (Pb, Cr, Cu, Zn). Their main source was multidimensional anthropogenic pollution leading to a biogenic-anthropogenic association of elements. Sapropel with low concentrations of heavy metals exhibits a different inter-association matrix because most of the elements tend to form lithogenic-clastogenic associations.
Characterization of an H6N1 avian influenza virus from an illegally imported product
Authors: wang yan , jiang ming wen , li ping jin , zhang ping lei , zhang qiang , li yang chun 
Published: February 2020

Abstract
Background : H6N1 is low pathogenic virus commonly found in wild and domestic birds across many continents. To investigate the infective status of imported food, we detected avian influenza virus (AIV) in illegally imported frozen food from international flight. Methods : The virus was isolated, the complete genome was sequenced, and the pathogenicity was tested. PQIATR/G was found in the motif of the HA cleavage site of the isolated strain, which conforms to the molecular characteristics of a low pathogenic AIV. The amino acid residues at positions 186, 190, 226, and 228 of the HA protein receptor binding sites were proline (P), valine (V), glutamine (Q), serine (S), respectively, exhibiting the molecular characteristics required to bind to human-like receptors. The SPF chicken test showed that the IVPI was 0 and the virus was a low pathogenic AIV. The infectious results in BALB/c mice showed that the isolate could be replicated in the lower respiratory tract of mice. Mice infected with a high dose of the virus displayed moderate weight loss but no obvious clinical symptoms. Results :The results of the sequence analysis showed that the avian influenza virus was of the H6N1 subtype, which shared the highest nucleotide identity with the AIV subtypes prevalent in Taiwan province. Conclusions : It is important to intensily monitor the illegal carrying.
Morbidity and mortality in the antiretroviral era in sub-Saharan Africa: a systematic review protocol
Authors: Ghislain Manimani Riziki , MUSHEBENGE AGANZE Gloire-Aime , MAGULA NOMBULELO 
Published: February 2020

Abstract
Background Worldwide, Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome (HIV/AIDS) remains a public health problem. The prevalence of HIV in Sub-Saharan Africa is one of the uppermost in the world. Method/design Observational studies will be systematically reviewed reporting on morbidity and mortality in the antiretroviral therapy (ART) era in Sub-Saharan Africa. We will search relevant studies from the following databases: PubMed, Medline, CINAHL. Two review authors will independently screen titles abstracts and full text articles in duplicate, extract data and assess the bias. Discrepancies will be resolved by discussion or arbitration of a third review author. The study will use the Preferred Reporting Item of Systematic Review (PRISMA 2015) guideline. Discussion This review will summarise the determinants of morbidity and causes of mortality in the antiretroviral era in Sub-Saharan Africa. The findings of this study will help to improve opportunistic infection’s prevention and clinical outcomes in ART era. Systematic review registration PROSPERO CDR42019141933
Determinants of Real Exchange Rate: An analysis from macroeconomic internal factors in Latin American countries
Authors: Chavez Carlos 
Published: February 2020

Abstract
This paper study the macroeconomic factors than explain the real exchange real movements. We use a GMM Panel Vector Autoregressive, propose by Love and Zicchino (2006), for a period 1980-2016, graphs the impulse-response functions and his variance decomposition. We estimate a Vector Autoregressive model for each country. The results are heterogeneous when we compare the results by group and by each country, but we found significance in our variables on real exchange rate.
Study of the efficacy of the elastic intramedullary nails in the treatment of primary aneurysmal bone cysts in extremities
Authors: Wang Yi-chen , Jia Xing , Shen Yan , Wang Sun , Dong Liang-chao , Ren Jing , Zhao Li-Hua 
Published: February 2020

Abstract
Background The main treatment method of the primary aneurysmal bone cyst (ABC) in extremities is to curettage and bone grafts with high-speed burring, radiotherapy, sclerotherapy, arterial embolism and hormone therapy can be used for the lesions whose location cannot be easily exposed by the surgery. Regardless of the method, high recurrence rates are a common problem. Purpose To explore and compare the effect and efficacy of the elastic intramedullary nails in the treatment of primary ABC in extremities. Method 26 patients with primary ABC admitted and treated from 2010 to 2016 were studied retrospectively. 26 patients were divided into 2 groups according to the treatment plan: the patients of the control group received curettage and bone grafts with high-speed burring; the patients of the study group received curettage and bone grafts with high-speed burring + elastic intramedullary nail (ESIN). According to the imaging results (Neer grading) and MSTS(musculoskeletal tumor society)functional evaluation, the curative effect of the children of the 2 groups were analyzed statistically. Results A total of 10 patients of the control group received curettage and bone grafts with high-speed burring and a total of 16 patients of the study group received curettage and bone grafts with high-speed burring + ESIN. All of the patients were followed up for more than 2 years. 9 of the 26 patients recurred. According to the imaging results and MSTS function evaluation, there was statistically significant difference in the curative effect between the 2 groups ( P < 0.05).The recurrence cases in the study group have a better MSTS functioncal recovery. Conclusion Curettage and bone grafts with high-speed burring + ESIN can significantly reduce the recurrence rate of primary ABC in extremities. The using of ESIN has a good curative effect and efficacy.
A transparent cap assisted endoscopic injection sclerotherapy for the treatment of patients with esophageal varices
Authors: Wang Jing , Zhang Xiaohua , Zhao Shulei 
Published: February 2020

Abstract
Aim: The aim of this study was to compare the efficacy and safety of cap assisted endoscopic injection sclerotherapy(EIS) versus direct endoscopic injection sclerotherapy(EIS) in the management of patients with cirrhosis after esophageal variceal bleeding . Methods: Patients with cirrhosis suffering from esophageal variceal bleeding who underwent EIS with or without the help of a transparent cap in Shandong Provincial Hospital between Novermber December 2014 and April 2017 were included in this retrospective study. All of the cases included in the study were divided into two groups: Group A (EIS with a transparent cap, n=50), Group B (direct EIS, n=45). Data collected included patients’ demographics, details of the procedure, variceal eradication, variceal rebleeding, variceal recurrence and survival during the follow-up period. All data were expressed as mean ± SD. Quantitative variables were compared by Student t test, and qualitative variables were compared by the Fisher exact test or the chi-square test. A P value less than 0.05 was considered significant. Results: The mean duration of follow-up was similar in both groups(16.3±10.2 mo and 15.5±9.5 mo, respectively). To achieve the eradication of varices, the volume of sclerosant (64.86±10.62 ml vs 104.73±21.25 ml, P =0.044), the mean number of sessions (2.37±1.15 times vs 5.70±1.57 times, p =0.042), the time required to perform endoscopic treatment(6.57±1.50 minutes vs 11.22±2.29 minutes, P =0.049) and the time for the initial esophageal varices eradication were significantly reduced in the cap assisted EIS group than in the direct EIS group(5.43±1.38 weeks vs 8.93±1.5 weeks, P =0.041). The probability of variceal recurrence and rebleeding was significantly higher in the direct EIS group than in cap assisted EIS group. Only 22 patients (44%) developed complications in the cap assisted EIS group as compared to 30 patients ( P =0.039) in the EIS group. The probability of survival was similar in both groups ( P =0.133). Conclusion: EIS with a transparent cap is an effective and safe treatment for esophageal varices.
Value of serum and follicular fluid Sirt1,Sirt2 protein levels in predicting the outcome of assisted reproduction
Authors: Yao Lingnv , Lin Wenqin , Jiang Nan , Li Chuyan , Cao Haifeng , Li Hong , Qian Jianhua 
Published: February 2020

Abstract
Background: To explore whether serum and follicular fluid Sirt1, Sirt2 can reflect ovarian reserve and predict the outcome of assisted reproduction. Methods: The study population comprised 125 patients , 39 in OPOI（occult form of premature ovarian insufficiency）group, 49 in advanced age group , and 37 in control group. The levels of serum Sirt1, Sirt2 were measured on the 2nd to 5th day of menstruation (bSirt1,bSirt2) and HCG day. Follicular fluid Sirt1 (FFSirt1) and Sirt2 (FFSirt2), were determined on OPU (oocyte pick up) day. Results: The level of FFSirt2 in the advanced age group was significantly lower than those in other two groups. FFSirt 2 and Sirt 2 (HCG day ) were negatively correlated with age (r=-0.35, r=-0.19), but there were no value of them for assessing DOR (diminished ovarian reserve). The level of bSirt2 in (cumulative) pregnant group was significantly higher (r=0.24, P=0.00). Conclusions: This was the first study to show that FFSirt2 and Sirt2 (HCG day) might be negatively correlated with age and antral follicle count (AFC). bSirt2 could predict cumulative pregnancy outcome together with anti-Mullerian hormone (AMH), AFC and age.
Use of Neural Network in Predicting Gastric Cancer with Para-aortic Lymph Node Metastasis in a Hospital Population Within the Last Two Decades
Authors: Zhang Lu , Zhang Hao , Xu Hong 
Published: February 2020

Abstract
Background: In clinical practice, the accurate prediction of para-aortic lymph node status and the selection of appropriate surgery methods can significantly affect the prognosis of patients with gastric cancer. In the present study, we reviewed the data of patients who underwent radical gastric cancer surgery with dissection of para-aortic lymph nodes (PANs) within the last 20 years and assessed the possible independent predictors of PAN status. Methods: We included 308 patients with gastric cancer who fulfilled the inclusion criteria, and logistic regression and neural network were utilized to identify the possible independent predictors of PAN status. Results: Logistic regression analysis showed that male sex, Borrmann types III and IV, T4 stage, and pancreatic or splenic metastases were significant risk factors of PAN metastasis after adjusting for other factors, and the accuracy rate was 71.8%. After inputting all parameters into the neural network, the accuracy was 98%. Conclusion: The neural network has significant benefits in predicting PAN status in patients with gastric cancer. The finding of this study may be useful in predicting PAN metastasis.
Immune Gene Data-based Molecular Subtyping of Rectal Adenocarcinoma Related to Prognosis
Authors: sen Xia shu , Tian Hong-peng , Liu Zuo-liang , Yan Zai-hua , Wang Xian-yan , Meng Chang-yuan , Li Li-fa , Tang Xue-gui , Zhang GuangJun 
Published: February 2020

Abstract
Background: The morbidity and mortality of rectal adenocarcinoma (READ) is increasing, which is considered as an aggressive type of colorectal malignancy. A great deal of evidence has suggested the significant association between the progression of READ and the immunophenotype of tumor cells (i.e. the expression of intracellular immune-related genes).Methods: Samples retrieved from the TCGA and ImmPort database were investigated to identify immune-related genes specifically impacting the prognosis of READ patients. Several typical ones were then selected to construct the prognostic prediction model of READ patients through Lasso algorithm. The training and test cohorts were incorporated into the model, respectively. We stratified READ patients to evaluate the accuracy, efficiency and stability of the model in the prediction and classification of patient prognosis according to the value of median RiskScore (Risk-H and Risk-L). GO and KEGG signaling pathway enrichment analysis were conducted among the nine selected immune-related genes.Results: A total of 57 immune-related displaying marked correlated with patient prognosis were identified and nine most typical genes could be majorly enriched into several pathways with close correlation with READ and the corresponding immune response. the distribution of nine immune-related genes were examined in the samples from both Risk-H and –L groups. Finally, the connection of the RiskScore value with the clinical characteristics of sample and the related signaling pathways were investigated.Conclusions: The prognostic prediction model of RiskScore constructed based on the expression profiling of the nine immune-associated genes exhibited high prediction accuracy and stability to identify the relevant immune features. This model could contribute to the guidance for clinicians in diagnosing and predicting the prognosis for various immunophenotypes. Meanwhile, it also can offer various therapeutic targets for precise treatment of READ in clinical practice according to the identified immune molecules specific to different subtypes.
Resource-saving: main formation stages, theories and methods, tendencies and prospects of development in industry and construction of Russia
Authors: Tshovrebov Eduard S. 
Published: February 2020

Introduction. The paper considers one of the actual modern ecological, technological, and economic problems. It is saving, rational usage of natural, mineral, and energy resources. Based on an in-depth review of scientific researches and normative documents, the paper suggests ways of solving the resource-saving problem within a context of sustainable development of industry and construction, the formation of “green” economics, provision of ecological safety, scientific and technological development of Russia.
Materials and methods. The paper analysed foreign and domestic publications, normative legal acts, documents on standardization in the field of formation of a conceptual system, legal standards, fundamental theories, concepts, and methods, advanced guidelines of developing the resource-saving, rational usage of natural resources, involving secondary resources in economic turnover. A systemic analysis of methods and algorithms for solving the scientific problem was suggested as a research method.
Results. For the first time in modern scientific literature, the paper gives comprehensive theme review of normative and methodological literature, scientific research works in the field of different aspects of the resource-saving: legal, organizational and technical, ecological, technological, social and economic ones. The paper reveals and formulates priority guidelines to be thoroughly researched in the future by theoretical and applied sciences. The paper proposes concrete measures of normative and legal regulation, organization, economic incentives of activities in the field of the resource-saving and usage of the secondary resources.
Conclusions. The scientific novelty is concluded in the suggested systemic approach to forming an integrated resource-saving system at the state, sectoral, and production levels as an efficient tool for developing domestic economics.
KRITIK IBN WARRAQ ATAS ORIENTALISME EDWARD SAID: PERDEBATAN EPISTEMOLOGIS MENGENAI ‘TIMUR DAN BARAT’
Authors: Bahri Media Zainul 
Published: February 2020

This article tries to describe Ibn Warraq's critique onEdward Said's monumental work, "Orientalism (1979)" in four main areas; Said anti-Western; misunderstanding on Western culture; orientalism and imperialism; and the relationship of Western music with the Eastern world. Based on critical study approach to the two monumental works of thesetwo intellectual figures, the results of the study show that even Said has never "responded" to Warraq's criticism directly, but Said's views and thoughts after his publication of the work "Orientalism", had become a kind of "defense" and "weapons", which counterattacked to his critics. Said's thesis against Warraq's anti-thesis, which later led to synthesis, and likewise the circulation of theory and theoretical criticism, has made a very significant contributionto the development of science. Through a very serious academic debate between Warraq and Said, the perspectives of scientists and people in generalhave become clearer.
KOMPETENSI PERADILAN TATA USAHA NEGARA TERHADAP PENGAWASAN PENYELENGGARAAN PEMERINTAHAN DITINJAU DARI PERLUASAN ASAS-ASAS UMUM PEMERINTAHAN YANG BAIK PASCA BERLAKUNYA UNDANG-UNDANG NOMOR 30 TAHUN 2014 TENTANG ADMINISTRASI PEMERINTAHAN
Authors: Melissa Silalahi Devi 
Published: February 2020

This article discusses Administrative Court’s control function in governance toward implementation of government’s duties. As we know, Administrative Court has its role to resolve any administrative disputes between government and citizens. The aims of this article is to know deeply the competency of Administrative Court after the enactment of Law Number 30 Year 2014 about Government Administration as the law regulates main material sources of state administrative law. This is due to the addition of general principles of good governance’s types to file a tort claim for an unlawful act committed by government. Moreover, general principles of good governance become a legal instrument for Judges of State Administration Court to review the legality of any decision of State Administration. In the Article 10 Law Number 30 Year 2014 is stated that there are eight types general principle of good governance. However, Judges has a right to look broader and find another types beyond that eight in order to make legal decision. Therefore, Law Number 30 Year 2014 becomes foundation of the main material law of state administrative procedure law. In the other hand, Law Number 30 Year 2014 requires government to publish every administrative decree based on provisions in law and general principles of good governance.