bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kepatuhan Diet Pada Pasien Gagal Ginjal Kronis di Unit Hemodialisa Rumah Sakit Sumber Waras
Authors: Rahayu Cicielia Ernawati 
Published: November 2019

Gagal ginjal kronis (GGK) merupakan suatu sindrom klinis yang disebabkan gangguan fungsi ginjal yang yang bersifat menahun, berlangsung progresif dan irreversible, Penatalaksanan pasien GGK tahap akhir selain dilakukan tindakan hemodialisa, diet dan pembatasan cairan., yang berlangsung terus menerus dan membutuhkan kepatuhan bagi pasien. Tujuan penelitian untuk mengetahui faktor-faktor yang berhubungan dengan kepatuhan diet pada pasien GGK di RS Sumber Waras. Metode penelitian deskriptif analitik dengan ujisatatisik Chi Square dengan tingkat kemaknaan 95% yang meliputi analisa univariat maupun bivariat. Hasil penelitian didapatkan 72,5% responden tidak patuh terutama pada pasien yang hemodialisa lebih dari 6 bulan. Hasil analisa Chi Square terbukti ada pengaruh pengetahuan terhadap kepatuhan diet padapasiengagalginjalkronissecarabermakna (p0,006). Ada pengaruh lamanya menjalani terapi hemodialisa terhadap kepatuhan diet pada pasien gagal ginjal kronis secara bermakna (p0,00). Kesimpulan kepatuhan diet pada pasien gagal ginjal kronis secara bermakna, dengan pengetahuan dan lamanya responden menjalani tindakan hemodialisa. Rekomendasi perlu dilakukan penelitian lanjutan mengenai faktor- faktor yang dapat meningkatkan kepatuhan pasien terhadap diet, terapi cairan maupun hemodialisa. Kata Kunci: Kepatuhan Diet, Gagal Ginjal Kronis, Hemodialisa
STRATEGI KOMUNIKASI PENINGKATAN PRAKTEK IMUNISASI DIFTERI PADA IBU BALITA DI PUSKESMAS CIJEDIL, DINAS KESEHATAN KABUPATEN CIANJUR
Authors: Juhamad Juhamad , Krianto Tri 
Published: November 2019

Difteri merupakan salah satu penyakit menular dan sering menimbulkan kejadian luar biasa (KLB) di beberapa wilayah. Difteri merupakan penyakit yang sering menyebabkan kematian, karena racun yang dihasilkan oleh bakteri Corynebacterium diphterie. Berdasarkan masalah yang terjadi di Kabupaten Cianjur mulai pada tahun 2013 ditemukan penderita difteri sebanyak 6 kasus dan 1 orang meninggal dengan Case Fatality Rate sebesar 17%. Sedangkan pada tahun 2015 ditemukan penderita difteri sebanyak 3 kasus. Kemudian pada tahun 2017 terdapat 15 pasien difteri yang ditangani RSUD Cianjur beberapa diantaranya dirujuk ke Rumah Sakit Hasan Sadikin Bandung karena jumlah penderita meningkat sedangkan ruang isolasi terbatas. Salah satu daerah yang terjadi KLB yaitu tepatnya di wilayah kerja Puskesmas Cijedil. Data vaksinasi yang di dapat di Puskesmas Cijedil yaitu berjumlah 86 bayi laki-laki dan 87 bayi perempuan sehingga jumlahnya 173 bayi laki- laki dan perempuan, sedangkan yang sudah mendapatkn vaksinasi DPT 1 dan HB1 untuk kategori bayi laki laki berjumlah 71 atau 82,6 % dan kategori bayi perempuan berjumlah 84 atau 96,6 % yang sudah mendapatkan imunisasi DPT1 dan HB1. Penelitian ini mengunakan desain metode kualitatif yang mempelajari tentang peningkatan praktek imunisasi difteri pada ibu balita di Puskesmas Cijedil,Dinas Kesehatan kabupaten cianjur mulai bulan Februari sampai Maret 2019 dan pengumpulan data dilakukan dengan wawancara dengan ibu balita dan petugas kesehatan, kader posyandu. Hasil penelitian menunjukan bahwa adanya peningkatan praktek imunisasi pada ibu balita di Desa Cijedil tahun 2019. dari hasil wawancara mendalam menggunakan kuesioner di dapatkan bahwa ibu balita terkait pengerahuan ibu balita tentang imunisasi difteri dan pencegahan difteri menunjukan adanya peningkatan praktek imunisasi difteri. Disarankan kepada petugas Petugas promosi kesehatan Dinas Kesehaan Cianjur agar lebih ditingkatkan lagi kunjungan imunisasi setiap satu bulan sekali agar peserta imunisasi difteri dapat mengerti betul tentang pencegahan penyakit difteri. Kata kunci: Difteri, Strategi Komunikasi Praktek Imunisasi, Kabupaten Cianjur
La ville intelligente sans les villes ?
Authors: Bernardin Stève , Jeannot Gilles 
Published: November 2019

L’article présente en premier lieu une double recension bibliographique sur le thème des villes intelligentes et sur celui de l’informatisation des administrations. La présentation des articles du numéro porte l’attention sur les coordinations organisationnelles et professionnelles internes aux administrations municipales et sur les interactions nouvelles avec les citoyens et les entreprises avant de conclure sur l’enjeu d’une maîtrise par les administrations publiques des nouvelles données associées à la « smart city ».
Legal Barriers to the Development of Digital Distribution Channels in the Activities of Insurance Companies in Poland
Authors: Wrzesiński Piotr 
Published: November 2019

The use of modern technologies in business is primarily aimed at simplifying business processes, reducing the costs of business operations as well as improving the quality of services offered to clients. It is also a response to the changing preferences of customers who are increasingly using digital solutions. Technological solutions may in particular be used in the insurance distribution process, which in recent years has become much more demanding, due a number of provisions regulating the distribution of insurance contracts were introduced. These changes are mainly aimed at ensuring that client makes conscious decisions regarding the conclusion of the contract, due to broad information requirements as well as matching the insurance to the client's needs. The use of mobile applications, Big Data, artificial intelligence or blockchain technology may allow for simplification, acceleration and reduction of costs in the process of distribution of insurance contracts. The article is an attempt to indicate the main possibilities of using technological solutions, both in relation to the requirements for insurance distributors and in relation to the technologies that can be used. Selected barriers were also discussed, which in the author's opinion significantly limit the possibility of development of digital insurance distribution channels.
Concentrated ambient PM2.5exposure affects mice sperm quality and testosterone biosynthesis
Authors: Yang Yingying , Yang Tingting , Liu Shengxin , Cao Zhijuan , Zhao Yan , Su Xiujuan , Liao Zehuan , Teng Xiaoming , Hua Jing 
Published: November 2019

BackgroundStudies suggested that PM2.5exposure could lead to adverse reproductive effects on male animals. However, the underlying mechanism is still not clear. Besides, animals in the majority of previous studies were exposed to PM2.5through intratracheal instillation which should be improved. In addition, limited amount of research has been conducted in China where the PM2.5concentration is higher and the PM2.5components are different. The aim of this work is to explore the effects of concentrated ambient PM2.5(CAP) on mice sperm quality and testosterone biosynthesis.MethodsA total of 12 male C57BL/6 mice were exposed to filtered air (FA) or CAP for 125 days using the Shanghai Meteorological and Environmental Animal Exposure System. The mice sperm concentration, sperm motility, DNA fragmentation index, high DNA stainability and plasma testosterone were analyzed. Testicular histology and sperm morphology were observed through optical microscope. Testosterone biosynthesis related gene expressions were analyzed using real-time PCR, including cytochrome P450 CHOL side-chain cleavage enzyme (P450scc), steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β HSD), 17β-hydroxysteroid dehydrogenase, cytochrome P450 aromatase (P450arom), estrogen receptor (ER), androgen receptor (AR) and follicle stimulating hormone receptor (FSHR).ResultsExposure to CAP resulted in disturbance of various stages of spermatogenesis and significant higher percentage of abnormal sperm (FA vs. CAP: 24.37% vs. 44.83%) in mice testis. CAP exposure significantly decreased sperm concentration (43.00 × 106vs. 25.33 × 106) and motility (PR: 63.58% vs. 55.15%; PR + NP: 84.00% vs. 77.08%) in epididymis. Plasma testosterone concentration were significantly declined (0.28 ng/ml vs. 0.69 ng/ml) under CAP exposure. Notably, the levels of testosterone biosynthesis related genes, StAR, P450scc, P450arom, ER and FSHR were significantly decreased with CAP exposure.ConclusionConcentrated ambient PM2.5exposure altered mice sperm concentration, motility and morphology, which might be mediated primarily by the decline in testosterone concentration and testosterone biosynthesis process.
Synthesis, Characterization, Spectral Studies and Antimicrobial Study on Mixed Ligand Complexes of Chloro-arsenic(III) Derived from β-Ketiminates & Piperidine Dithiocarbamate Ligand Moity
Authors: Kumar Sharma Deepak , Sharma Jyoti , Sharma Ramavtar 
Published: November 2019

A series of Chloro-arsenic(III) complexes with N, O donor β-ketiminate ligand (L1) and S, S donor piperidine dithiocarbamate ligand (L2) have been synthesized by the reactions of AsCl3 with both ligands in equimolar ratio by stirring at room temperature in benzene solution. All these synthesized compounds have been characterized by Elemental Analysis, IR, (1H and 13C) NMR Spectral and ESI-Mass Studies. Both Ligands and their corresponding Chloro-arsenic (III) complexes have been screened for antimicrobial activity against the various bacterial (E. Coli, B. Subtalis and P. Aeruginosa) and fungal (T. Resei, P. Funiculosum and Fusarium) strains and results obtained .
Pedotransfer Functions for Estimating Saturated Hydraulic Conductivity of Selected Benchmark Soils in Ghana
Authors: Tuffour Henry Oppong , Abubakari Awudu , Agbeshie Alex Amerh , Khalid Abdul Aziz , Tetteh Erasmus Narteh , Keshavarzi Ali , Bonsu Mensah , Quansah Charles , Oppong Jimmy Clifford , Danso Lawrence 
Published: November 2019

Aims: Direct methods of measuring saturated hydraulic conductivity (Ks), either in situ or in the laboratory, are time consuming and very expensive. Several Pedotransfer functions (PTFs) are available for estimating Ks, with each having its own limitations. In this study, the performances of four popular PTFs were evaluated on different soil classes in the semi deciduous zone of Ghana. The PTFs considered herein were Puckett et al. (1985), Campbell and Shiozawa (1994), Dane and Puckett (1994), and Ferrer-Julià et al. (2004). In addition, five local data derived PTFs were used to study the possibility of using local datasets to validate PTF accuracy.
Materials and Methods: A total of 450 undisturbed soil cores were collected from the 0 – 15 cm depth from three benchmark soils, namely, Stagni-Dystric Gleysol (SDG), Plinthi Ferric Acrisol (PFA) and Plinthic Acrisol (PA). The Ks of samples were measured by the falling-head permeameter method in the laboratory. Sand, silt and clay fractions, bulk density, organic matter content, and exchangeable calcium and sodium were measured and used as input parameters for the newly derived PTFs. Accuracy and reliability of the predictions were evaluated by the root mean square error (RMSE), coefficient of correlation (r), index of agreement (d), and the Nash-Sutcliffe efficiency (NSE) between the measured and predicted values from both tested and newly derived PTFs. The relative improvement (RI) of the newly derived PTFs from this study over the existing ones were also evaluated.
Results: The newly derived PTFs in this study had higher prediction accuracy with r, d, RMSE and NSE ranging from 0.80 – 0.99, 0.79 – 0.94, 0.14 – 1.74 and 0.84 – 0.98, respectively, compared with 0.32 – 0.45, 0.27 – 0.50, 4.00 – 4.90 and 0.41 – 0.47 for the tested PTFs. The relative improvement of the newly derived over the tested PTFs ranged from 56.50 – 95.71% in the SDG, 70.73 – 96.89% in the PFA, and 65.37 – 95.81% in the PA. Generally, RI was observed to be highest for Model 1 in the SDG, and Model 4 in both PFA and PA, and lowest for Model 5 in all three soils. It was observed that the inclusion of exchangeable calcium and sodium as predictors increased the predictability of the newly derived PTFs.
Implication of Proteus spp in the Pathology of Nosocomial Wound Infection in Northeastern Nigeria
Authors: M. Tom Isyaka , B. Agbo E. , A. Faruk Umar , M. Umoru Askira , M. Ibrahim Muhammad , B. Umar Jidda , B. Haruna Ali , Aliyu Abdullahi 
Published: November 2019

Aims: To determine the infection rate and antibiogram of Proteus spp among hospitalised patients suffering from wound infection in Maiduguri.
Methodology: A total of 320 wound swab samples were collected from August 2016 to June 2017, and processed via microscopy, culture and further confirmed by biochemical tests. Kirby bauer disc diffusion test was used to determine the antimicrobial susceptibility pattern of Proteus spp isolated.
Results: Twenty eight (28) samples yielded Proteus spp, giving a prevalence rate of 8.75%. Male patients were more affected (60.71%) compared to females (39.29%). Difference in sex in relation to rate of infection was statistically not significant (X2 =3.963, p<.01). Patients within the age group of 21-30 years (28.57%) recorded the highest bacterial yield while those of 61-70 years and >70 years (3.57% respectively) recorded the least. Patients suffering from Wound Sepsis and Burns recorded the most significant infection rate (28.57% respectively). Proteus mirabilis (53.57%) was the most isolated Proteus specie while Proteus penneri (7.14%) was the least. Proteus spp isolates demonstrated a marked resistance against Augmentin (89.29%) and Nalidixic Acid (85.71%) but high sensitivity was observed towards Ciprofloxacin (85.71%) and Streptomycin (78.57%).
Conclusion: We establish that Proteus spp actually contribute to the pathology of wounds infection among hospitalised patients, and the Proteus specie most implicated in the aetiology of wound infection is Proteus mirabilis. Ciprofloxacin and Streptomycin are the drugs of choice for the treatment of patients with Proteus spp wound infection in the study area, and the use of Nalidixic acid and Augmentin is highly discouraged due to high resistance.
Overview of Major Bacterial Contaminants of Drinking Water in Nigeria: A Review
Authors: Otorkpa Oche Joseph 
Published: November 2019

Aim and Objectives: The objective of this study was to provide an overview of the microorganisms implicated in the contamination of household drinking water in Nigeria, their pattern of distribution and the regulatory gap(s) if any that is responsible for the cases of drinking water contamination and water borne diseases in Nigeria.
Study Design and Methodology: The methodology employed for this study involved a comprehensive and critical review of ten randomly selected studies to identify the major bacterial contaminants of drinking water in Nigeria and their distribution. This review was restricted to microbiological measures of drinking water contamination excluding chemical aspects of water quality.
Results: Escherchia coli was found to be the predominant microbial contaminant of drinking water in the studies reviewed with 70%, Klebsiella sp 60%, Pseudomonas aeruginos 60%, Staphylococcus aureus 50%, Proteus sp 50%, Enterobacter aerogenes 40%, Streptococcus fecalis 30%, Salmonella typhi 30% and 10% for Vibrio cholerae and Shigella sp.
Conclusion: The presence of microbes in drinking water especially E. coli reported in 70 percent of the studies reviewed is a source of concern. The presence of toxin producing strains of E. coli like the O157:H7 in drinking water can result in fatal consequences like hemorrhagic diarrhea and kidney failure. The widespread presence of other disease-causing organisms further confirms that a good number of the drinking water presented as safe for consumption across Nigeria are actually not fit for human consumption. The gaps reported in most of the studies reviewed were mainly oversight gaps in monitoring by the National Agency for Food and Drug Administration and control, NAFDAC, the agency charged with monitoring food and drugs in the country.
Eat Fast, Die Young: The Pattern of Fast Food Consumption amongst International Medical Students
Authors: Kalidass Shantosh , Binti Azhar Fatin Aizaa , Ann Zee Gan , Noor Hasani Muhamad Noor Zuhairi Bin , T. K. Madhura , Javali S. B. , Patil P. A. 
Published: November 2019

Objective: To investigate the factors influencing fast-food consumption amongst the International Medical Students of USM-KLE.
Hypothesis: Fast food consumption is deleterious to the overall health of a person, and thus we expect low fast food consumption amongst medical students of USM-KLE. Nevertheless, due to the lack of awareness and poor understanding of the ill effects of fast food consumption, the pattern of fast food consumption is increasing among the medical students of USM-KLE.
Materials and Methods: A cross-sectional survey-based study was conducted in the month of June 2018 by distributing questionnaires to 326 Malaysian students –from year 1 to year 5 – who are studying in Belgaum, India. The questions touched on the aspects of their profile, driving factors of fast food consumption, routine exercise pattern, and their knowledge on the deleterious effects of fast food on their health. Data was collected for their experience both in Malaysia & India, & these were then analysed using SPSS 16.0 software.
Results: In this study, the results were coded & translated according to each question. It is observed that there is a high prevalence of fast food consumption amongst the students; 97% of the students consume fast food.
Conclusion: The results of this study showed that despite their knowledge on the poor health effects of these foods. the students prefer to consume fast food mostly on the basis of their hectic schedule, the restaurants’ close distance, the good taste of the meals, as well as their fast availability.
Economic Evaluations of Cabazitaxel for Treatment of Post-docetaxel Metastatic Castration-resistant Prostate Cancer: Evidence from a Systematic Review
Authors: Shahmirzadi Nikinaz Ashrafi , Zaboli Pardis , Afzali Monireh , Molla Tigabu Bereket , Hajimiri Mirhamed , Ajami Arman , Sepehri Nima 
Published: November 2019

Background and Objectives: Prostate cancer is an ever-increasing global incidence and has become the fifth leading cause of cancer-related mortality in men. A significant number of patients with prostate cancer develop metastatic castration-resistant prostate cancer (mCRPC). There are a few second-line treatment options for patients with post-docetaxel mCRPC. This systematic review aimed to assess the cost-effectiveness of cabazitaxel for the treatment of mCRPC.
Materials and Methods: Electronic bibliographic databases including: PubMed/Medline, NICE, CRD, and Scopus were searched in January 2018 for identifying full economic evaluations published in English and Persian. The risk of assessment bias and descriptive analyses of individual studies’ findings were presented.
Results: Three articles that fulfilled the inclusion criteria were included in the current study. All the included records had a reasonable quality. Cabazitaxel was not recommended as the most cost-effective option for the treatment of docetaxel-refractory mCRPC. Abiraterone acetate and radium-223 were the recommended cost-effective treatments for mCRPC treatment.
Conclusion: We found that, in general, while cabazitaxel had equal or slightly higher improvement in Quality-adjusted Life Year (QALY) as compared to the alternatives, it incurred a high cost. Despite the inclusion of a few studies in this review, cabazitaxel was not found to be a cost-effective option. Therefore, we recommend full economic evaluations to be conducted in this area.
Minipigs: Applications in Toxicology
Authors: Brown Larry D. , Stricker‐Kongrad Alain , Bouchard Guy F. 
Published: November 2019

AbstractMinipigs are accepted models for a variety of drug preclinical and nonregulatory toxicology studies. Acute, subchronic and chronic studies are possible using all routes of administration. Minipigs have distinct size advantages over domestic pigs. There exist some minor limitations with minipigs, but for the most part they offer well correlated models to humans for dermal and systemic toxicology assessments. Phototoxicology and reproductive toxicology usage is expanding. Minipig size, anatomy, physiology, metabolism, and genetics generally correlate well to human factors. The minipig makes an appropriate model for toxicology. Curr. Protoc. Toxicol. 56:1.11.1‐1.11.19. © 2013 by John Wiley & Sons, Inc.
Reversible Conversion between Schottky and Ohmic Contacts for Highly Sensitive, Multifunctional Biosensors
Authors: Zhao Luming , Li Hu , Meng Jianping , Wang Aurelia Chi , Tan Puchuan , Zou Yang , Yuan Zuqing , Lu Junfeng , Pan Caofeng , Fan Yubo , Zhang Yaming , Zhang Yan , Wang Zhong Lin , Li Zhou 
Published: November 2019

AbstractSchottky and Ohmic contacts–based electronics play an important role in highly sensitive detection of biomolecules and neural electric impulses, respectively. The reversible conversion between these two contacts appears especially important for multifunctional sensing by just one biosensor. Here, Schottky barrier height (SBH) is successfully tuned by triboelectric nanogenerator (TENG) and the same device is made to achieve reversible conversion between Schottky contact and Ohmic contact. In the same Schottky to Ohmic reversible (SOR) biosensor, highly sensitive detections of biomolecule (i.e., neurotransmitter) and neural electric signal are achieved at different contact states. The SOR biosensor reveals the feasibility of using one device to realize multifunctional detection. This work proposes a simple and significant method to achieve reversible tuning between the Schottky contact and Ohmic contact on one device by TENG, which exhibits great potential in developing multifunctional and high‐sensitivity biosensors, rectifiers, and other functional electronic devices.
Cobalt Single‐Atom‐Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity
Authors: Chen Zhongxin , Liu Cuibo , Liu Jia , Li Jing , Xi Shibo , Chi Xiao , Xu Haisen , Park In‐Hyeok , Peng Xinwen , Li Xing , Yu Wei , Liu Xiaowang , Zhong Linxin , Leng Kai , Huang Wei , Koh Ming Joo , Loh Kian Ping 
Published: November 2019

AbstractThe identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long‐standing pursuit in chemical synthesis. A vertically structured, cobalt single atom‐intercalated molybdenum disulfide catalyst (Co1‐in‐MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single‐atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide‐bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high‐value, multifunctional sulfones and late‐stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom‐intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.