bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erich Joachimsthaler: The principle of shared value drives the success of the “interaction field” business model
Authors: Leavy Brian 
Published: January 2021

Purpose
Strategist Erich Joachimsthaler in his new book “The Interaction Field: The Revolutionary New Way to Create Shared Value for Businesses, Customers and Society,” predicts that in future traditional basis of value creation will be replaced by a business model of value creation where everyone becomes a producer and consumer, a participant in an ever changing, flexible and very large network of participants.

Design/methodology/approach
This interview of the author by Prof. Brian Leavy looks at how interaction field companies or business models create shared value by solving new or intractable problems for customers, the industry or society.

Findings
The new consumers expect to be active participants in value creation as they engage, participate, share, contribute, comment, benefit and learn.

Practical implications
The key to creating maximum shared value and exponential growth is velocity, the number or frequency and the quality of interactions between everyone in the interaction field.

Originality/value
A thoughtful introduction to an important new business model. Critical learning for executives designing digital platforms.
RepC_soli: a novel promiscuous plasmid type of Rhodobacteraceae mediates horizontal transfer of antibiotic resistances in the ocean
Authors: Birmes Lukas , Freese Heike M. , Petersen Jörn 
Published: January 2021

SummaryAlphaproteobacteria are typically characterized by a multipartite genome organization with a chromosome, stable chromids and accessory plasmids. Extrachromosomal elements determine the lifestyle of roseobacters and their horizontal transfer was previously correlated with rapid adaptations to novel ecological niches. We characterized the distribution and biology of a novel Rhodobacteraceae‐specific plasmid type that was designated RepC_soli according to its diagnostic solitary replicase. This low copy number replicon exhibits an exceptional stability, which is likely ensured by non‐canonical separate parA and parB partitioning genes. RepC_soli plasmids occur frequently in the surface‐associated marine genus Phaeobacter and comparative genome analyses revealed the emergence of four compatibility groups. The universal presence of conserved type IV secretion systems in RepC_soli plasmids is indicative of their recurrent mobilization, a prediction that was experimentally validated by conjugation of the 57 kb Phaeobacter inhibens P72 plasmid (pP72_e) over genus borders. RepC_soli plasmids harbour a diverse collection of beneficial genes including transporters for heavy metal detoxification, prokaryotic defence systems and a conspicuous abundance of antibiotic resistance genes. The pP72_e‐encoded efflux pump FloR conferred an about 50‐fold increase of resistance against chloramphenicol. Its specific occurrence in Phaeobacter likely reflects a genetic footprint of (former) antimicrobial use in marine aquaculture.
OSIP1 is a self‐assembling DUF3129 protein required to protect fungal cells from toxins and stressors
Authors: Valette Nicolas , Renou Julien , Boutilliat Alexis , Fernández‐González Antonio José , Gautier Valérie , Silar Philippe , Guyeux Christophe , Charr Jean‐Claude , Cuenot Stéphane , Rose Christophe , Gelhaye Eric , Morel‐Rouhier Mélanie 
Published: January 2021

SummarySecreted proteins are key players in fungal physiology and cell protection against external stressing agents and antifungals. Oak stress‐induced protein 1 (OSIP1) is a fungal‐specific protein with unknown function. By using Podospora anserina and Phanerochaete chrysosporium as models, we combined both in vivo functional approaches and biophysical characterization of OSIP1 recombinant protein. The P. anserina OSIP1Δ mutant showed an increased sensitivity to the antifungal caspofungin compared to the wild type. This correlated with the production of a weakened extracellular exopolysaccharide/protein matrix (ECM). Since the recombinant OSIP1 from P. chrysosporium self‐assembled as fibers and was capable of gelation, it is likely that OSIP1 is linked to ECM formation that acts as a physical barrier preventing drug toxicity. Moreover, compared to the wild type, the OSIP1Δ mutant was more sensitive to oak extractives including chaotropic phenols and benzenes. It exhibited a strongly modified secretome pattern and an increased production of proteins associated to the cell‐wall integrity signalling pathway, when grown on oak sawdust. This demonstrates that OSIP1 has also an important role in fungal resistance to extractive‐induced stress.
The faulty SOS response of Pseudomonas putida KT2440 stems from an inefficient RecA‐LexA interplay
Authors: Akkaya Özlem , Aparicio Tomás , Pérez‐Pantoja Danilo , de Lorenzo Víctor 
Published: January 2021

SummaryDespite its environmental robustness Pseudomonas putida strain KT2440 is very sensitive to DNA damage and displays poor homologous recombination efficiencies. To gain an insight into this deficiency isogenic ∆recA and ∆lexA1 derivatives of prophage‐free strain P. putida EM173 were generated and responses of the recA and lexA1 promoters to DNA damage tested with GFP reporter technology. Basal expression of recA and lexA1 of P. putida were high in the absence of DNA damage and only moderately induced by norfloxacin. A similar behaviour was observed when equivalent GFP fusions to the recA and lexA promoters of E. coli were placed in P. putida EM173. In contrast, all SOS promoters were subject to strong repression in E. coli, which was released only when cells were treated with the antibiotic. Replacement of P. putida's native LexA1 and RecA by E. coli homologues did not improve the responsiveness of the indigenous functions to DNA damage. Taken together, it seems that P. putida fails to mount a strong SOS response due to the inefficacy of the crucial RecA‐LexA interplay largely tractable to the weakness of the corresponding promoters and the inability of the repressor to shut them down entirely in the absence of DNA damage.
Does educational investment enhance capacity development for Nigerian youths? An autoregressive distributed lag approach
Authors: Emediegwu Lotanna Ernest 
Published: January 2021

AbstractThis paper employs the autoregressive distributed lag bound test and Nigerian time series data spanning 1980–2016 to provide empirical evidence on the educational financing—(youths) capacity development nexus via secondary school enrollment channel. The greatest factor that is pivotal to developing the capacity of Nigerian youths is investment in the quantity of education, and more significantly in its quality. The paper's main results show that budgetary allocation to education positively and significantly impacts secondary school enrollment, both in the long and short runs. Thererfore, the study recommends a substantial investment in the educational sector even if there has to be a trade‐off with other types of unproductive investment.
Does board gender diversity matter in the banking sector? Evidence from Tunisia
Authors: Othmani Hidaya 
Published: January 2021

AbstractThe purpose of this paper is to investigate the effects of board gender diversity on banks’ performance and risk for the case of a developing African country. Our sample includes a unique data set of Tunisian banks during the period 2005–2018. We use the two‐way cluster regression proposed by Petersen. This approach corrects for the unobserved firm effect (time‐series dependence) and time effect (cross‐sectional dependence). It gives robust standard errors adjusted for heteroscedasticity, serial correlation, and cross‐sectional correlation. Our results support a positive relationship between gender diversity and banks’ performance measured by ROA and ROE, while women board members are associated with more default risk measured by Z‐score. Our results remain robust to various measures of gender diversity, banks’ performance and risk. The findings contribute to the literature by providing empirical evidence from Tunisia, an African emerging economy, where the examination of the role of board gender diversity on bank governance is unexplored.
Saving for a Rainy Day… or a Trip to the Bahamas? How the Framing of Investment Communication Impacts Retail Investors
Authors: Hillenbrand Carola , Saraeva Anastasiya , Money Kevin , Brooks Chris 
Published: January 2021

AbstractLittle is known to date regarding how the framing of investment communication impacts retail investor propensity to engage with financial products. To explore this lacuna, we apply insights from regulatory focus theory and construal level theory, and we vary investment communications in terms of the motivation (protect vs. achieve) and the time horizon (distant vs. near) presented in a 2 × 2 quasi‐experimental design. We also include an analysis of investor characteristics and find that communication of ‘short‐term achieve’ investments attracts particularly risk‐tolerant and sensation‐seeking individuals, posing questions of responsibility towards potentially vulnerable groups. We also find that negative attitudes towards finance may be troublesome, as they can stop individuals from engaging with ‘long‐term’ investment products. Positive attitudes towards finance, in contrast, lead investors to engage with ‘protect’ products of both ‘short‐’ and ‘long‐term’ horizon, highlighting benefits for individuals and society from interventions aimed at financial education and exposure. The study concludes by discussing insights for the literature and practitioners from the application of new theory and new data to the management of investment communications.
The Brexit Negotiations and the Anglosphere
Authors: Gamble Andrew 
Published: January 2021

AbstractThe Brexit negotiations raise the question of what Britain’s future role in the world should be. Brexiters have drawn on ideas of the Anglosphere to imagine what that future might be. The Anglosphere belongs in a long line of thinking about uniting English speaking communities around the world. Different conceptions of the Anglosphere such as CANZUK are identified. The Anglosphere appeals to many Brexiters because it gives them a positive vision of ‘Global Britain’ as an alternative to EU membership. The advantages to Britain of regaining full sovereignty and associating once more with its ‘true friends’ are stressed. What is ignored is the lack of support among Anglosphere countries for much closer relationships except in the security sphere, and the inability of increased economic ties with the Anglosphere to begin to match what the UK will lose by severing itself from its most important economic partner.
Evaluating the robustness of the CMS Hospital Value‐Based Purchasing measurement system
Authors: Revere Lee , Langland‐Orban Barbara , Large John , Yang Yijiong 
Published: January 2021

AbstractBackgroundThe Hospital Value‐Based Purchasing Program (HVBP) is a pay for performance system that impacts traditional Medicare fee‐for‐service payments to hospitals through rewards and penalties.ObjectivesTo explore variation in overall and individual‐hospital total performance score (TPS) and embedded domains for hospitals during 2014‐2018.Data SourceHospital data were retrieved from the publicly available HOSArchive dataset.Study DesignDistribution of annual TPS and HVBP domain scores for 2014‐2018 was evaluated using descriptive statistics. Transitional probabilities were analyzed to evaluate annual movement in the TPS ranking for outlier hospitals in the Top and Bottom 5%.Principal FindingsTPS scores are positively skewed while the distribution of domain scores vary with patient experience, (clinical) outcome, and efficiency domains having a large number of (positive) outliers. Mean TPS score decreased from 40.54 in 2014 to 38.04 by 2018. Improvement was shown in mean domain scores for clinical process of care and clinical outcome using 95% confidence intervals, with hospitals gaining 10 points over the study period in clinical outcome. Changes in the mean scores for other domains did not show consistent increases or decreases. Chi‐square analyses of hospital ranking categories showed some evidence that, as a group, hospitals initially ranked in the Bottom 5% are making consistent annual movements to higher categories. In contrast, over half of the hospitals ranking in the initial Top 5% remained in the top category across all study years.ConclusionsIt may be time for CMS to redesign the HVBP incentive program to assure the measures accurately demonstrate sustained improvement, the domain weights appropriately reflect the level of importance, and the TPS comparative ranking methodology does not discourage lower‐performing hospitals from actively improving the care they deliver and achieving top ranks.
Validation of a clinical decision instrument for emergent neuroimaging after a seizure: Let’s image malignancy, intracranial hemorrhage, and trauma (LIMIT)
Authors: Isenberg Derek L. , Muller Megan , Rodrigues Laura , Reimer Hannah , Finlaw Lilian , Souiarov George , Loughran Sarah , Gentile Nina T. 
Published: January 2021

AbstractBackgroundGiven the many causes of seizures, emergency physicians often utilize brain computed tomography (CT) to evaluate for intracranial pathology. However, a CT exposes patients to 100 times more radiation than a chest radiograph. Previously, we developed a four‐item clinical decision instrument (CDI) to determine which patients with status epilepticus (SE) do not require emergent neuroimaging. In this study, we seek to prospectively validate our CDI in patients with a history of seizures with both SE and generalized tonic–clonic seizures.MethodsThis was a prospective observational study of 1,739 consecutive patients who were recruited from two urban hospitals in Philadelphia, Pennsylvania. All patients, 18 years and older, who presented with a chief complaint of seizure and had emergency neuroimaging performed were eligible for inclusion. Patients were excluded from analysis if this was a first‐time seizure, had a ventriculoperitoneal shunt, or had focal neurologic deficits.ResultsA total of 376 patients were in the final analysis. Of the 376 patients, 10 patients (3%) had positive CTs. Nine of the 10 of the patients were identified by our CDI, resulting in a negative predictive value (NPV) of 99.5%. On secondary analysis, we refined our CDI from four to three criteria: 1) history of intracranial hemorrhage (ICH), 2) active malignancy, and 3) trauma. These criteria also had a NPV of >99% when applied to patients in SE.ConclusionThe validation of our CDI showed improved NPV when compared to the derivation set. Use of the criteria of history of ICH, active malignancy, and trauma could have reduced the use of emergent neuroimaging in our cohort by up to 49%. This CDI should be validated in a larger subset of patients and in multiple centers prior to widespread adoption.
5HT‐2C agonist lorcaserin decreases cannabis self‐administration in daily cannabis smokers
Authors: Arout Caroline A. , Cooper Ziva D. , Reed Stephanie Collins , Foltin Richard W. , Comer Sandra D. , Levin Frances R. , Haney Margaret 
Published: January 2021

AbstractThere are no FDA‐approved treatments for cannabis use disorder (CUD). Preclinical research has shown that the 5HT‐2C agonist lorcaserin attenuates cue‐induced reinstatement of THC seeking and self‐administration. The goal of this placebo‐controlled, counterbalanced, within‐subject human laboratory study was to examine lorcaserin's effects on cannabis intoxication and self‐administration. Lorcaserin (10 mg BID) was administered during one of two 13‐day inpatient phases and placebo during the other; each phase was separated by ≥7 days of washout. Inpatient phases comprised (1) standardized cannabis administration (7.0% THC) at no financial cost (intoxication), counterbalanced with (2) the option to self‐administer cannabis following either 0 or 3 days of abstinence. Cognitive task performance, food intake, subjective ratings of drug effects, objective/subjective sleep measures, and tobacco cigarette use were also assessed. Fifteen normal‐weight, daily cannabis users (4F, 11M) not seeking treatment for CUD completed the study. Lorcaserin significantly reduced cannabis self‐administration following 0 and 3 days of cannabis abstinence and also reduced craving for cannabis during abstinence. Lorcaserin produced small but significant increases in positive cannabis ratings and body weight relative to placebo. Lorcaserin also reduced tobacco cigarette smoking on days of cannabis administration relative to placebo. During abstinence, subjective but not objective measures of sleep quality worsened during lorcaserin maintenance. Overall, lorcaserin's ability to decrease drug taking and cannabis craving in nontreatment‐seeking cannabis users supports further investigation of 5HT‐2C agonists as potential pharmacotherapies for CUD.
A simple technique of vaginal cuff closure to prevent tumor cell spillage in laparoscopic radical hysterectomy for uterine cervical cancer
Authors: Deura Imari , Kanamori Ryo , Nagasawa Yuko , Kuji Shiho , Ohara Tatsuru , Tozawa Akiko , Shimada Muneaki , Suzuki Nao 
Published: January 2021

AbstractIntroductionThe Laparoscopic Approach to Cervical Cancer (LACC) trial, a prospective randomized phase III clinical trial reported in 2018, unexpectedly showed inferior oncologic outcomes in laparoscopic radical hysterectomy (LRH) for cervical cancer compared with those in open surgery. It was proposed that the spillage of tumor cells into the peritoneal cavity might cause the inferiority of LRH. It has been suggested, based on retrospective studies, that transvaginal closure of the vaginal cuff before the colpotomy part of the surgery may prevent this.Materials and Surgical TechniqueBefore starting colpotomy, we closed the vaginal cuff transvaginally. After the assessment of the cutline of the vagina, the vaginal mucosa is pulled at the eight sites using the sutures. The four pairs of sutures on the diagonal line are ligated. A purse string suture is additionally placed on the vaginal mucosa to close the vaginal cuff completely. After that, we start the intracorporeal colpotomy using a vaginal pipe.DiscussionOur technique is simple and quick. The blood loss during the transvaginal procedures is minimal. The use of the vaginal pipe helps keep the vaginal cuff closed during the colpotomy. Our technique may be an alternative to the conventional approach closing the vaginal cuff.
Are heritage speakers of Spanish significantly better at speaking than at writing? Results of an experiment on writing and speaking proficiencies—Actual and perceived
Authors: Gatti Alberta , Graves Syelle 
Published: January 2021

AbstractIt is often assumed that heritage language learners (HLLs) speak better than they write—by themselves and by educators alike. This article draws on data from writing and oral proficiency ratings plus self‐evaluations of 35 Spanish HLLs to investigate: (i) whether Spanish HLLs actually tend to receive higher ratings in speaking than in writing; (ii) if this is the case, how large the distance in proficiency is; and (iii) to what extent HLLs are accurate in identifying their better modality. Results do show higher ratings in speaking on average, but to a degree that is smaller than might be expected: ratings indicate that subjects performed the same functions in both modalities even when one of the two was rated higher than the other. Additionally, fewer than half the subjects were able to accurately evaluate whether or not they are better at speaking or writing. Implications for instruction are also discussed.
Fluorine loss determination in bioactive glasses by laser‐induced breakdown spectroscopy (LIBS)
Authors: de Pablos‐Martín Araceli , Contreras Jaimes Altair T. , Wahl Stefanie , Meyer Sylke , Brauer Delia S. 
Published: January 2021

AbstractFluoride‐containing bioactive glasses and glass‐ceramics in the SiO2‐P2O5‐CaO‐CaF2 system are of great interest for dental applications, where the precipitation of fluorapatite supports tooth remineralization. Fluorine quantification in those glasses is key to estimate thermal properties and crystallization tendency. This work presents a study on fluorine determination by laser induced breakdown spectroscopy (LIBS) in four melt‐derived glass powders with varying P2O5 concentrations. LIBS enables fluorine quantification with a reduced analysis time, minimal to no sample preparation, and high spatial resolution. The fluorine calibration curve was obtained from CaF2 and SiO2 mixtures as reference samples, and the fluorine loss upon glass melting has been determined as a function of P2O5 content. The P2O5‐free glass shows the lowest fluorine loss (13%), with HF volatilization likely being responsible for the loss. By contrast, the glass with the highest P2O5 content (11.33 wt%) exhibits the largest fluorine loss (55%), owing to additional mechanisms involving the volatilization of phosphorus species like POF3.
Effect of oxidation and hydrolysis of porcine myofibrillar protein on Nε‐carboxymethyl‐lysine formation in model systems
Authors: Yu Ligang , He Zhiyong , Zeng Maomao , Yang Yukun , Chen Jie 
Published: January 2021

SummaryThis study investigated the effects of oxidation and hydrolysis of porcine myofibrillar protein (MFP) on Nε‐carboxymethyl‐lysine (CML) formation in model systems. Model systems of MFP/oxidised linoleic acid (MFP/OLA), mildly oxidised MFP/OLA (MO‐MFP/OLA), severely oxidised MFP/OLA (SO‐MFP/OLA), mildly hydrolysed MFP/OLA (MH‐MFP/OLA) and severely hydrolysed MFP/OLA (SH‐MFP/OLA) were incubated, and CML content was determined. Compared with MFP/OLA (39.1 ± 5.7 ng mg−1 protein), there was a significant increase of CML in MO‐MFP/OLA (53.9 ± 2.5 ng mg−1 protein), whereas a marked decrease was observed in SO‐MFP/OLA (25.1 ± 4.4 ng mg−1 protein) during incubation. CML level increased with increasing degree of hydrolysis of MFP after 6 days of incubation. Therefore, mildly oxidised MFP and hydrolysed MFP could promote CML formation, while severely oxidised MFP impeded CML generation. These results suggested that effects of oxidation and hydrolysis of MFP on CML generation were mainly dependent on the degree of structural changes of MFP.