bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Propensity to Die at Home for People with Cancer in Scotland 2001-2011: Evidence from A Data Linkage Study
Authors: Atherton Iain , Schneider Anna , Henderson David 
Published: December 2020

IntroductionThe proportion of deaths at home amongst cancer patients has increased internationally in recent years. This trend has become evident in Scotland. Underlying reasons are unclear and may include changing hospital policy decisions and changing social and demographic composition of the population.
Objectives and ApproachTo assess the drivers behind increased odds of dying at home amongst people who died of cancer in Scotland between 2001 and 2011. Data from the 2001 and 2011 censuses for everyone who was living at home at enumeration to death registration data for all deaths occurring in the 12 months following census. A dataset was created of everyone whose death was indicated to be from cancer. Bivariate and multivariate analysis was test hypotheses that (1) hospital discharge, and (2) that changes in socio-economic characteristics might explain the change.
ResultsThere were 12,640 deaths from cancer in the 12 months following the 2001 census, 13,167 following the 2011 census. Odds of dying at home were greater during the later period (OR 1.13). There was no evidence to suggest discharge from hospital in the days before death explained this change. Bivariate analysis demonstrated increased odds of dying at home associated with younger age, being a home owner, being married, and living with others. However, introducing these variables to logistic regression models made little difference to the changing odds of dying at home between the two census periods.
Conclusion / ImplicationsThe lack of impact on the odds of dying at home in Scotland between the two census periods suggests either policy or improved palliative care to be behind the shift. However, the findings with regard to drivers behind place of death suggests future projections should factor in changing social and demographic composition of the population in later life to anticipate future trends in place of death.
Javanese Language Shift in the Coastal Area of Special Region of Yogyakarta Province
Authors: Atmawati Dwi 
Published: December 2020

The reduced ability of children and young people to speak Javanese has motivated researchers to conduct research on the shift in Javanese language. The data in this study are primary data. Respondents were selected by purposive sampling technique. The data were processed using the SPSS program and then analyzed qualitatively and quantitatively. The theory used to discuss the problems in this study is the theory of language shift. The results of this study indicate that in the DIY coastal area there is a shift in the use of Javanese. In the past, Javanese was used to communicate in the family and in daily conversations with fellow Javanese people, now some of its speakers have switched to using Indonesian. In fact, some parents use Indonesian as a mother tongue to their children. Speakers of children and adolescents tend to be less able to speak Javanese well, both ngoko and krama. Adult speakers tend to speak Javanese, both ngoko and krama. However, the mastery tends not to be as good as older speakers. The vitality of the Javanese language in the DIY coastal area based on the calculation of the indicator index is 0.73. The index value indicates that Javanese in the DIY coastal area is in the index number 0.61-0.80 or is in a stable but threatened position.
DIFFERENCES IN CHANGES OF HEMOGLOBIN BETWEEN 6-12 HOURS AND 12-14 HOURS AFTER TRANSFUSION
Authors: Linda Rosita , Ninda Devita 
Published: December 2020

Each year more than 41,000 blood donations are needed every day and 30 million blood components are transfused. Blood products that can be transfused include Packed Red Cells (PRC), Whole Blood (WB), Thrombocyte Concentrate (TC), Fresh Frozen Plasma (FFP). Monitoring Hemoglobin (Hb) after transfusion is essential for assessing the success of a transfusion. The time factor after transfusion for Hemoglobin (Hb) examination needs to be established, analyze to judge the success of a blood transfusion which is performed. The aim of this study was to analyze the differences in changes of hemoglobin between 6-12 hours, and 12-24 hours after-transfusion. This study was retrospective observational using secondary data. The subjects were patients who received PRC, and WBC transfusion. At 6-12, and 12-24 hours after-transfusion, hemoglobin, RBC, and hematocrit were measured. Then the data were analyzed by unpaired t-test. The collected data included the results of the Hb pre-transfusion, 6-12, and 12-24 hours after-transfusion. The subjects of this study were 98 people. The administration of transfusion increased by 10-30% in hemoglobin concentration at 6-12 hours after-transfusion. While at 12-24 hours after-transfusion, hemoglobin after-transfusion increased 15-37% from the baseline. Hemoglobin values were not different at any of the defined after-transfusion times (p = 0.76 (p>0.05)). Hemoglobin values were not different at 6-12 hours, and 12-24 hours after-transfusion. Keywords: Hemoglobin, measurement, after-transfusion
RELATIONSHIP BETWEEN NEUTROPHIL - LYMPHOCYTE RATIO AND DECREASED GLOMERULAR FILTRATION RATE IN DIABETIC NEPHROPATHY
Authors: Azikin Asriyani , Mangarengi Fitriani , Bahrun Uleng 
Published: December 2020

Diabetic nephropathy is one of the fairly severe Diabetes Mellitus (DM) complications and the main cause of renal failure that can result in mortality. Hyperglycemia in DM induces kidney injury that may result in hemodynamic and metabolic alterations, endothelial dysfunction and inflammatory cells activation. A persistent and continuous inflammation is observed in diabetic nephropathy. One of the inflammation process progression indicators is Neutrophil-Lymphocyte Ratio (NLR). To find out the relationship between NLR and decreased Glomerular Filtration Rate (GFR) in diabetic nephropathy. This study was an observational study with a retrospective approach. This study was conducted in Clinical Pathology Laboratory Installation and Medical Record Installation of Dr. Wahidin Sudirohusodo Makassar Hospital by collecting the patient's data during February 2015 to February 2016. Patients that were diagnosed as type 2 DM without diabetic nephropathy complication were taken as control and those diagnosed as type 2 DM with diabetic nephropathy were treated as study subjects. One hundred and thirteen (113) samples met the inclusion criteria, consisting of 73 diabetic nephropathy patients with Chronic Kidney Disease (CKD) 13 diabetic nephropathy patients without CKD and 27 type 2 DM patients without diabetic nephropathy complication. Patients consisted of 57 males (50.4%) and 56 females (49,6%). Neutrophil-lymphocyte ratio and GFR values in the group of diabetic nephropathy without CKD were 2.03±0.68 and 85.38±24.63, respectively. Whereas, the NLR and GFR values in control group were 1.74±0.54 and 90.03±28.60, respectively. In the group of diabetic nephropathy with CKD, NLR value increased by 3.19±1.83 and GFR decrease by 30.54±16.45. Spearman test indicated a significant relationship between NLR increase and decreased GFR (r = -0.635, p=0.00). There is a significant relationship between NLR increase and decreased GFR in patients with diabetic nephropathy.
ANÁLISE ECONÔMICA DO PLANTIO DE CROTALÁRIA (Crotalariajuncea L.) PARA PRODUÇÃO DE SEMENTES EM ÁREAS DE REFORMA DA CANA-DE-AÇÚCAR
Authors: BOSCOLO Adriano , SOARES Welton da Silva , CARVALHO Jaqueline Bonfim de , APARECIDO Camila Fernandes F. 
Published: December 2020

A cultura da cana-de-açúcar possui destaque em cenário nacional, principalmente no Estado de São Paulo, sendo de grande utilização à prática de plantio de leguminosas para período de descanso nas áreas de cultivo da cultura. Diante da necessidade de alcançar maiores índices de produtividade e redução de custo, é necessário buscar alternativas de consorciamento de culturas, a fim de quebrar o ciclo de pragas e doenças e também produzir efeitos que ocorrem naturalmente e causando benefícios ao solo. Logo, o objetivo do presente trabalho é de avaliar o custo de produção da Crotalariajuncea L., analisando a viabilidade para produção de sementes, em áreas de descanso de cana-de-açúcar no município de Ilha Solteira, SP. Foram calculados os custos operacionais totais e índices de lucratividade para a cultura da Crotálariajuncea L. O Custo operacional total (COT) é R$ 3.078,09 por hectare. Dentro dos custos analisados, o que mais onerou o COT foi a colheita, correspondendo a 19,49%. O índice de lucratividade foi negativo de 58%, fato atribuído à extensão do período vegetativo da planta, que não mostra todo seu potencial produtivo e, consequentemente, não cobre os custos de produção do presente estudo.

ECONOMIC ANALYSIS OF CROTALARIA (Crotalariajuncea L.) PLANTING FOR SEED PRODUCTION IN SUGARCANE REFORM AREAS

ABSTRACT
Sugarcane crops have been evidenced in the national scenario, mainly in São Paulo State, it is highly used leguminous plants during the rest period in areas where those crops are cultivated. In view of the need to reach higher productivity indexes and save costs, it is crucial to search for alternatives for companion planting, in order to break the cycle of plagues and diseases as well as reducing the effects naturally caused by them and in addition to benefiting the soil. Accordingly, this paper aims to review the Crotalariajuncea L. production costs, considering the seeds production viability, in sugarcane resting areas in the municipality of Ilha solteira, SP. The total operating cost and profit rates for Crotálariajuncea L. crops were calculated. The total operating cost (TOC) is R$ 3.078,09 per hectare. Within the budget, the harvest was the one that encumbered it the most, corresponding to 19,49%. The profit index was 58% negative, which could be attributed to the fact of the extension of the growing season of the plant, which does not reveal all its productive potential and, consequently, does not cover the production costs of the present research.

Keywords: Costs. Profit Index. Economic Viability. Cover Plants.
Riesgo biológico generado por el manejo de residuos sólidos en un centro hospitalario
Authors: Quintana-Salcedo Álvaro , Ramos-De La Espriella Carolin , Lugo-Calderón Edgar 
Published: December 2020

El objetivo de este artículo es evaluar el riesgo biológico generado por el manejo de residuos sólidos por parte del personal de servicios generales en la E.S.E Hospital Local Cartagena de Indias. Se realizó un estudio descriptivo de enfoque cuantitativo. Se utilizó la matriz de riesgo de la guía técnica colombiana 45 y la encuesta de 14 ítems basada en el Sistema de Vigilancia Epidemiológica para el Riesgo Biológico (modelo para el control del riesgo biológico) de la ARL SURA aplicado al sector hospitalario. La muestra fue de 34 trabajadoras del área de servicios generales, distribuidos en los CAP intraurbanos de la E.S.E. Cartagena. Los resultados muestran que las actividades donde presenta mayor contacto con agentes biológicos son en el lavado de camillas, cambio de bolsas rojas para residuos peligrosos y lavado de guardián (se observó durante el desarrollo de la investigación), siendo esta última inusual. Se concluye que las medidas preventivas y de seguridad que adopta el personal en su puesto de trabajo son eficientes en relación a tener su área limpia y en orden, son conscientes que al realizar sus actividades entran en contacto con agentes biológicos. Por ello se deben realizar capacitaciones de autocuidado, capacitación e inspección del uso y mantenimiento de los elementos de protección personal, así mejorando las acciones preventivas evitando accidentes o enfermedades laborales.
Mutation variability in the filaggrin gene in patients with ichthyosis vulgaris
Authors: Живайкина Н.А. , Малютина Е.В. , Машкевич Д.А. , Васильева М.А. , Максимова Ю.В. 
Published: December 2020

Обследован 21 пациент с клиническими проявлениями вульгарного ихтиоза. Наиболее часто у них выявлялась мутация 2282del4 в гене FLG как в гомозиготном (у 6 больных), так и в гетерозиготном состояниях.
We examined 21 patients with clinical manifestations of ichthyosis vulgaris. Most often, they had the 2282del4 mutation in the FLG gene both in homozygous (in 6 patients) and heterozygous states.
A pilot study on ethical issues in genetic counseling
Authors: Зобкова Г.Ю. , Баранова Е.Е. , Ижевская В.Л. 
Published: December 2020

Приведены результаты пилотного исследования мнений врачей-генетиков по этическим проблемам медико-генетического консультирования методом анкетирования.
A pilot study was conducted to assess the existing problems of the prescriptive approach of Russian geneticists in genetic counseling
Tuberous sclerosis in the Republic of Sakha (Yakutia)
Authors: Софронова В.М. , Петухова Д.А. , Сухомясова А.Л. , Максимова Н.Р. 
Published: December 2020

Проведен ретроспективный клинико-генеалогический анализ 20 пациентов с диагнозом туберозный склероз. По результатам молекулярно-генетической диагностики в 3 неродственных якутских и 1 русской семьях выявлены 4 разных патогенных варианта нуклеотидной последовательности в генах TSC1, TSC2.
A retrospective clinical and genealogical analysis of 20 patients with a diagnosis of tuberous sclerosis was performed. According to the results of molecular genetics diagnostics, 4 different pathogenic variants of the nucleotide sequence in the TSC1, TSC2 genes were identified in 3 unrelated Yakut and 1 Russian family.
A high frequency of the PAX6 gene 3'-cis-regulatory region deletions in Russian aniridia patients
Authors: Васильева Т.А. , Марахонов А.В. , Кадышев В.В. , Зинченко Р.А. 
Published: December 2020

Врожденная аниридия (OMIM#106210) (ВА) - наследственное аутосомно-доминантное заболевание, ассоциированное с внутригенными мутациями гена PAX6 или крупными хромосомными аберрациями с вовлечением региона 11p13 в гетерозиготном состоянии. Проведено изучение особенностей спектра мутаций гена PAX6 и региона 11p13 в когорте пациентов с ВА из России. Обследованы 184 пациента из 152 неродственных семей. У 17 пациентов из 12 неродственных семей в регионе 11p13 обнаружены сходные делеции дистантной 3'-цис-регуляторной области гена PAX6 размером 0,3-1,5 млн п.н. Частота 3'-цис делеций составила 8% (12/152) и превысила частоту обычной нонсенс мутации в гене PAX6 c.718C>T (9/152, 6%). Высокая частота делеций указывает на возможно общий механизм их образования в «горячем» локусе региона 11p13.
Aniridia (OMIM 106210) is an autosomal dominant congenital disorder caused by heterozygous PAX6 intragenic mutations or chromosome 11p13 rearrangements. Molecular genetic study aimed to determine PAX6 damage spectrum peculiarities in Russian cohort. 152 unrelated families with congenital aniridia (184 patients) underwent ophthalmic examination and DNA testing. 17 patients from 12 unrelated families (4 familial and 8 sporadic probands) shared likely the same 11p13 0.3-1.5 Mb deletion affecting PAX6 downstream regulatory regions. The frequency of these deletions, 8% (12/152), was higher than PAX6 hotspot c.718C>T rate (8/152, 6%). A high rate of the deletions suggests a common underlying mechanism of its formation and points to 11p13 genomic region instability.
Difficulties in clinical diagnosis the atypical form of Andersen-Tawil syndrome
Authors: Колядин Д.А. , Федотова Т.В. , Кузнецова И.А. 
Published: December 2020

Синдром Андерсена-Тавила - редкое аутосомно-доминантное заболевание, при котором развиваются нарушение сердечного ритма, периодический паралич, лицевые и скелетные дизморфии. Вариабельность клинических проявлений усложняет постановку верного диагноза. В статье описывается клинический случай и анализируются особенности течения заболевания у пациента, правильный диагноз которому поставлен благодаря результатам секвенирования.
Andersen-Tawil syndrome is a rare autosomal dominant disease characterized by periodic paralysis, cardiac dysrhythmias, distinct facial and skeletal characteristics, that may be variably present in the affected members. In the article there is a clinical case with atypical presentations. The correct diagnosis has been done due to results of DNA sequencing.
Smith-Lemli-Opitz syndrome in the fetus of the second trimester of pregnancy with a predominant involvement skeletal system
Authors: Лазаревич А.А. , Новикова И.В. , Мясников С.О. , Венчикова Н.А. , Мараховская Э.И. , Плевако Т.А. 
Published: December 2020

Приведено описание спорадического случая синдрома Смита-Лемли-Опитца (СЛОС) у плода второго триместра. Основные ультразвуковые признаки были сходны с синдромом коротких ребер-полидактилии. Нозологический диагноз установлен при молекулярно-генетическом исследовании. Обсуждаются и сопоставляются нетипичные проявления СЛОС с данными литературы.
We present a sporadic case of Smith-Lemli-Opitz syndrome (SLOS) in the fetus of the second trimester. The ultrasound (US) signs were similar to the syndrome of short ribs-polydactyly (SCRP). The diagnosis was established by molecular genetic testing. The atypical manifestations of SLOS are discussed and compared with literature data.
Involvement of NBN gene polymorphism in predisposition to dystropic diseases
Authors: Постригань А.Е. , Бабушкина Н.П. , Кучер А.Н. 
Published: December 2020

Изучение генетических особенностей дистропных заболеваний (в том числе, астмы и туберкулеза), определяющих формирование взаимоисключающих фенотипов на клиническом уровне, важно для лучшего понимания их патогенеза. Цель настоящего исследования заключалась в оценке значимости генетического полиморфизма гена NBN в формировании предрасположенности к астме и туберкулезу. Изучена изменчивость rs1805800 и rs709816 гена NBN в выборках больных бронхиальной астмой (БА), туберкулезом (ТБ) и популяционной выборке г. Томска (ПВ), общая выборка составила 683 человека. Показано разнонаправленное изменение частот аллелей, генотипов, сочетаний генотипов по rs1805800 и rs709816 гена NBN между группами больных БА и ТБ по сравнению с популяционной выборкой. Для развития БА генотип CT rs1805800 обладает рисковым (OR=1,66, χ2=5,41, p=0,02); а генотипа СС - протективным (OR=0,57, χ2=5,57, p=0,018) эффектом. Статистически значимые различия между группами БА и ТБ выявлены также по частотам сочетаний генотипов rs1805800/rs709816 в гене NBN (χ2 = 12,88; p=0,045).
The research of genetic features of dystropic diseases (including asthma and tuberculosis) that determine the formation of mutually exclusive phenotypes at the clinical level is important for a better understanding of their pathogenesis. The aim of this study was to assess the significance of the genetic polymorphism of the NBN gene in the formation of a predisposition to asthma and tuberculosis. The variability of rs1805800 and rs709816 of the NBN gene in the samples of patients with bronchial asthma (BA), tuberculosis (TB) and the population sample of Tomsk (PV) was studied, the total sample was 683 people. The different-directional change of frequencies of alleles, genotypes, combinations of genotypes by rs1805800 and rs709816 of the NBN gene between groups of patients with BA and TB compared to the population sample is shown. For the development of BA, the genotype CT rs1805800 is risky (OR=1.66, χ2=5.41, p=0.02); And the SS genotype is a protective (OR=0.57, χ2=5.57, p=0.018) effect. Statistically significant differences between BA and TB groups are also revealed by the frequencies of combinations of the genotypes rs1805800/rs709816 in the NBN gene (χ2=12.88; p=0,045).
The content of heavy metals in the body and karyological indicators of genotoxicity
Authors: Реутова Н.В. , Реутова Т.В. , Дреева Ф.Р. , Шевченко А.А. 
Published: December 2020

Работа посвящена изучению возможных связей между содержанием тяжелых металлов в организме и кариологическими показателями клеток буккального эпителия. Обследовали детей, проживающих в районе расположения вольфрамо-молибденового комбината. Несмотря на повышенное содержание тяжелых металлов в объектах окружающей среды, их накопления в организме детей не выявлено. Обнаружены достоверные корреляции между содержанием марганца, цинка и меди в волосах с показателями клеточной пролиферации.
We studied possible relations between heavy metal content and cytogenetic characteristics of exfoliated buccal cells. To this end, we examined children living in the area where the tungsten-molybdenum plant is located. Despite the increased content of heavy metals in environmental objects, their accumulation in the hair of children was not detected. Significant correlations were found between the content of manganese, zinc and copper in the hair with the indicators of cell proliferation.
Modification of the clastogenic effects of cadmium in rat bone marrow with the melaxen
Authors: Чшиева Ф.Т. , Чшиев Т.В. , Кокаев Р.И. 
Published: December 2020

При хроническом применении мелаксена в дозе 10 мг/кг индукции генотоксических эффектов в костном мозге крыс не выявлено. Метафазный анализ после хронического совместного внутрижелудочного введения соли кадмия 0,3 мг/кг (в пересчете на металл) и мелаксена показал протекторные свойства последнего (р<0,01).
There was no reveled induction of genotoxic effects in rat bone marrow at the constant use of “melaxen” at a dose of 10 mg/kg. The chronic joint intragastric injection of a cadmium salt of 0.3 mg / kg (in terms of metal) and “melaxen “ showed the protective properties of the remedy (p<0.01) after metaphase analysis.
The modifying impact of melaxen on the genotoxic effects of chronic cadmium intoxication in rats
Authors: Чшиев Т.В. 
Published: December 2020

С использованием микроядерного теста было показано протекторное влияние мелаксена (10 мг/кг) при хронической экспериментальной интоксикации кадмием (0,3 мг/кг) в крови крыс, p<0,001. Исследуемый лекарственный препарат продемонстрировал способность снижать ожидаемое число микроядер и полихроматофильных эритроцитов (ПХЭ), индуцированных кадмием при двухнедельной и месячной экспозиции. При хроническом внутрижелудочном введении мелаксена не зафиксирован рост числа микроядер и ПХЭ по сравнению с контролем, p>0,05.
Using the micronucleus test, the protective effect of melaxen (10 mg / kg) was shown in chronic experimental cadmium intoxication (0.3 mg / kg) in rat blood, p <0.001. The studied remedy demonstrated the ability to reduce the expected number of micronuclei and polychromatophilic red blood cells (PCE) induced by cadmium during two-week and one-month exposure. In chronic intragastric injection of melaxen, an increase in the number of micronuclei and PCEs was not registered in comparison with the control, p> 0.05.
Genetic toxicology of pharmaceuticals: current state and perspectives
Authors: Жанатаев А.К. , Дурнев А.Д. 
Published: December 2020

Рассмотрено современное состояние исследований в области генетической токсикологии лекарственных средств, освещены стоящие перед ней прикладные и фундаментальные задачи.
The current state of research in the field of genetic toxicology of pharmaceuticals is discussed. Applied and fundamental problems of genetic toxicology are highlighted.