bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing supply chain risk for apparel production in low cost countries using newsfeed analysis
Authors: Handfield Robert , Sun Hang , Rothenberg Lori 
Published: June 2020

Purpose
With the growth of unstructured data, opportunities to generate insights into supply chain risks in low cost countries (LCCs) are emerging. Sourcing risk has primarily focused on short-term mitigation. This paper aims to offer an approach that uses newsfeed data to assess regional supply base risk in LCC’s for the apparel sector, which managers can use to plan for future risk on a long-term planning horizon.

Design/methodology/approach
This paper demonstrates that the bulk of supplier risk assessments focus on short-term responses to disruptions in developed countries, revealing a gap in assessments of long-term risks for supply base expansion in LCCs. This paper develops an approach for predicting and planning for long-term supply base risk in LCC’s to address this shortfall. A machine-based learning algorithm is developed that uses the analysis of competing hypotheses heuristic to convert data from multiple news feeds into numerical risk scores and visual maps of supply chain risk. This paper demonstrates the approach by converting large amounts of unstructured data into two measures, risk impact and risk probability, leading to visualization of country-level supply base risks for a global apparel company.

Findings
This paper produced probability and impact scores for 23 distinct supply base risks across 10 countries in the apparel sector. The results suggest that the most significant long-term risks of supply disruption for apparel in LCC’s are human resource regulatory risks, workplace issues, inflation costs, safety violations and social welfare violations. The results suggest that apparel brands seeking suppliers in the regions of Cambodia, India, Bangladesh, Brazil and Vietnam should be aware of the significant risks in these regions that may require mitigative action.

Originality/value
This approach establishes a novel approach for objectively projecting future global sourcing risk, and yields visually mapped outcomes that can be applied in forecasting and planning for future risks when considering sourcing locations in LCC’s.
Brand personality in cultural tourism through social media
Authors: Peco-Torres Francisco , Polo-Peña Ana I. , Frías-Jamilena Dolores M. 
Published: June 2020

PurposeThis study aims to analyze the effect of the use of social media on the perception of brand personality and to identify its effect on customer brand engagement.Design/methodology/approachThe study adopted an exploratory approach, adapting Aaker's brand personality scale (1997) to the context of cultural tourism before carrying out a quantitative study resorting to a structural equation modeling to obtain empirical evidence to identify these relationships.FindingsThe findings reveal that the use of social media has a positive effect on the perception of brand personality and that brand personality, likewise, has a positive effect on customer brand engagement.Research limitations/implicationsThis study indicates that transmission of an attractive brand personality according to the desires of the public, combined with dissemination through social media, is a valid strategy to improve customer brand engagement.Originality/valueThis study represents an advance in the specialized literature on the value that consumers place on information transmitted through social media. Specifically, it sheds light on how the transmission of brand personality through social media affects customer brand engagement.
Molecular characterization of rotaviruses obtained from patients with rotavirus‐associated encephalitis/encephalopathy
Authors: Ihira Masaru , Kawamura Yoshiki , Miura Hiroki , Hattori Fumihiko , Higashimoto Yuki , Sugata Ken , Ide Tomihiko , Komoto Satoshi , Taniguchi Koki , Yoshikawa Tetsushi 
Published: June 2020

AbstractGroup A rotavirus (RVA) rarely causes severe complications such as encephalitis/encephalopathy. However, the pathophysiology of this specific complication remains unclear. Next‐generation sequence analysis was used to compare the entire genome sequences of RVAs detected in patients with encephalitis/encephalopathy and gastroenteritis. This study enrolled eight patients with RVA encephalitis/encephalopathy and 10 with RVA gastroenteritis who were treated between February 2013 and July 2014. Viral RNAs were extracted from patients' stool, and whole‐genome sequencing analysis was carried out to identify the specific gene mutations in RVA obtained from patients with severe neurological complications. Among the eight encephalitis/encephalopathy cases, six strains were DS‐1‐like G1P[8] and the remaining two were Wa‐like G1P[8] (G1‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1). Meanwhile, eight of the 10 viruses detected in rotavirus gastroenteritis patients were DS‐1‐like G1P[8], and the remaining two were Wa‐like G1P[8]. These strains were further characterized by conducting phylogenetic analysis. No specific clustering was demonstrated in RVAs detected from encephalitis/encephalopathy patients. Although the DS‐1‐like G1P[8] strain was predominant in both groups, no specific molecular characteristics were detected in RVAs from patients with severe central nervous system complications.
Mercury spatial distribution characteristics and its exposure of the endangered Jankowski's bunting
Authors: Feng Zhili , Xiao Tingting , Zhang Gang , Zhang Lishi , Cui Yufei , Jiang Yunlei 
Published: June 2020

AbstractMercury (Hg) exposure is a potential reason for the endangered status of birds such as Jankowski's bunting. We measured mercury levels in the feathers and blood of the endangered bird Jankowski's bunting, along with mercury contents in the bird's food sources, nesting plants, nonfood plants, soil and air. Total mercury in feathers ranged from 162 to 489 ng/g (mean: 255 ± 104 ng/g). We observed significant bioaccumulation in the food chain from plants and grasshoppers to birds. The biological magnification factors were similar between four habitats, but significant differences were observed between trophic levels (p < .05). At all sampling sites, concentrations of total mercury in grasshoppers, nesting plants and food plants correlated with total mercury in bird feathers (p < .05). A nearby copper‐molybdenum mine influenced Hg exposure and distance from the mine was negatively correlated with mercury levels. Our study establishes the levels of mercury in Jankowski's bunting and in the birds' typical habitats.
Strategy emergence in service delivery networks: Network‐oriented human resource management practices at German airports
Authors: Sydow Jörg , Wirth Carsten , Helfen Markus 
Published: June 2020

AbstractOrganisational restructuring towards vertical disintegration and the accompanying rise of service delivery network (SDN) calls for closer attention, studying whether and how work and employment are strategically managed across organisational boundaries. In this paper, we adopt a “strategy‐as‐practice” approach to explain the emergence of an Human Resource Management (HRM) strategy which is geared towards managing work across organisational boundaries. Based on a comparison of two German major hub airports, we find that differences in network‐oriented HRM strategising in areas such as recruiting, remuneration and training result from micro‐political game playing. In this piecemeal process, management as well as external and internal stakeholders such as workers' representatives, and local and federal politicians participate by using their inter‐organisational relationships and institutionalised power resources to shape a network‐oriented HRM practice. With these findings, we contribute not only to HRM research from a strategy‐as‐practice perspective that is sensitive to institutions, but also to research on inter‐organisational collaboration that has neglected issues of HRM so far, by and large.
PD‐1/PD‐L1 negative schwannoma mimicking obstructive bronchial malignancy: A case report
Authors: Zhou Daibing , Xing Xiaoyan , Fan Jie , Zhang Youzhi , Liu Jie , Gong Yi 
Published: June 2020

AbstractSchwannomas are homogeneous tumors of schwann cells and occur at peripheral and cranial nerves on the upper limbs, the head and neck area. Rarely, a bronchial schwannoma may appear in the lung and be misdiagnosed as lung neoplasms. Here, we report a 56‐year old woman with a 5.8 × 7.0 × 2.8 cm lesion in her right upper lobe bronchus. The lesion had a maximum standardized uptake value (SUVmax) of 8.5 by 18‐fluorodeoxyglucose positron emission tomography (FDG‐PET). Bronchoscopy showed a mass obstructing the bronchus that bled easily. Despite repeated biopsies, a lung malignancy could not be excluded, and surgical resection was subsequently performed. Pathological examination demonstrated a primary bronchial schwannoma that was positive for molecular markers S‐100 and SOX‐10, negative for immune checkpoint marker PD‐1/PD‐L1 but also demonstrated certain uncommon pathological features. This case highlights the heterogeneity of bronchial masses and the diagnostic challenge for differentiating benign and malignant tumors in the thorax.Key points
Rare bronchial schwannoma mimics lung malignancy and poses a diagnostic challenge.
This case of bronchial schwannoma, unlike peripheral schwannoma, lacks PD‐L1. Pathological features indicate autonomic nerve origin for pulmonary schwannomas.
Alcohol use disorder and the gut
Authors: Haber Paul S. , Kortt Nicholas C. 
Published: June 2020

AbstractAcute and chronic gastrointestinal problems are common in the setting of excessive alcohol use, and excessive alcohol use is associated with injury to all parts of the gastrointestinal tract. There is mounting evidence of gastrointestinal injury and increased cancer risk even from moderate alcohol consumption. The major causes of alcohol‐related morbidity and mortality within the gastrointestinal system are liver disease, pancreatitis and gastrointestinal cancer. Other alcohol‐related intestinal dysfunction is common but not life‐threatening, leading to diarrhoea, malabsorption and nutritional deficiencies. This review describes non‐neoplastic and neoplastic alcohol‐related disorders of the gastrointestinal tract, omitting the liver, which has been reviewed elsewhere.
Genome‐wide association study of milk production traits in a crossbred dairy sheep population using three statistical models
Authors: Li H. , Wu X.‐L. , Tait R.G. , Bauck S. , Thomas D.L. , Murphy T.W. , Rosa G.J.M. 
Published: June 2020

SummaryMilk production is one of the most important characteristics of dairy sheep, and the identification of genes affecting milk production traits is critical to understanding the genetics and improve milk production in future generations. Three statistical techniques, namely GWAS, ridge‐regression BLUP and BayesC

, were used to identify SNPs in significant association with three milk production traits (milk yield, fat yield and protein yield) in a crossbred dairy sheep population. The results suggested that chromosomes 1, 3, 4, 5, 7 and 11 were likely to harbor genes important to milk production because these chromosomes had the greatest top‐100‐SNP variance contributions on the three milk production traits. The GWAS analysis identified between 74 and 288 genome‐wide significant SNP (P < 0.05) whereas the BayesCπ model revealed between six and 63 SNPs, each with >95% posterior probability of inclusion as having a non‐zero association effect on at least one of the three milk production traits. Positional candidate genes for milk production in sheep were searched, based on the sheep genomic assembly OAR version 3.1, such as those which map position coincided with or was located within 0.1 Mbp of a genome‐wide suggestive or significant SNP. These identified SNPs and candidate genes supported some previous findings and also added new information about genetic markers for genetic improvement of lactation in dairy sheep, but keeping in mind that the majority of these positional candidate genes are not necessarily true causative loci for these traits and future validations are thus necessary.
Haplotype‐based genome‐wide association studies reveal new loci for haematological and clinical–biochemical parameters in Large White pigs
Authors: Bovo S. , Ballan M. , Schiavo G. , Gallo M. , Dall’Olio S. , Fontanesi L. 
Published: June 2020

SummaryWe report haplotype‐based GWASs for 33 blood parameters measured in 843 Italian Large White pigs. In the single‐trait analysis, a total of 30 QTL for number of basophils, six erythrocyte traits (haemoglobin, haematocrit, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean corpuscular volume and red blood cell count) and two clinical–biochemical traits (alkaline phosphatase and Ca2+ contents) were identified. In the multiple‐trait analysis, a total of five QTL affected three different clusters of traits. Only four of these QTL were already reported in the single‐marker and multi‐marker GWASs we previously carried out on the same pig population. QTL on SSC11 and SSC17 showed effects on multiple traits. These results further dissected the genetic architecture of parameters that could be used as proxies in breeding programmes for more complex traits. In addition, these results might help to better define the pig as an animal model for several blood‐related biological functions.
Use of multispectral satellite datasets to improve ecological understanding of the distribution of Invasive Alien Plants in a water‐limited catchment, South Africa
Authors: Mtengwana Bhongolethu , Dube Timothy , Mkunyana Yonela P. , Mazvimavi Dominic 
Published: June 2020

AbstractInvasive Alien Plants (IAPs) pose major threats to biodiversity, ecosystem functioning and services. The availability of moderate resolution satellite data (e.g. Sentinel‐2 Multispectral Instrument and Landsat‐8 Operational Land Imager) offers an opportunity to map and monitor the occurrence and spatial distribution of IAPs. The use of two multispectral remote sensing data sets to map and monitor IAPs in the Heuningnes Catchment, South Africa, was therefore investigated using the maximum likelihood classification algorithm. It was possible to identify areas infested with IAPs using remote sensing data. Specifically, IAPs were mapped with a higher overall accuracy of 71%, using Sentinel‐2 MSI as compared to using Landsat 8 OLI, which produced 63% accuracy. However, both sensors showed similar patterns in the spatial distribution of IAPs within the hillslopes and riparian zones of the catchment. This work demonstrates the utility of the two multispectral data sets in mapping and monitoring the occurrence and distribution of IAPs, which contributes to improved ecological modelling and thus to improved management of invasions and biodiversity in the catchment.
Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper
Authors: Gelincik Aslı , Brockow Knut , Çelik Gülfem E. , Doña Inmaculada , Mayorga Cristobalina , Romano Antonino , Soyer Özge , Atanaskovic‐Markovic Marina , Barbaud Annick , Torres Maria Jose 
Published: June 2020

AbstractCoronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID‐19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off‐label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings together all the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off‐label drugs and highlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactions in the course of the disease.
Antidepressant effects of 3‐(3,4‐methylenedioxy‐5‐trifluoromethyl phenyl)‐2E‐propenoic acid isobutyl amide involve TSPO‐mediated mitophagy signalling pathway
Authors: Wei Qiang , Zhou Wangyi , Zheng Ji , Li Dongmei , Wang Mingyang , Feng Lu , Huang Wei , Yang Nan , Han Min , Ma Xiaohui , Liu Yanyong 
Published: June 2020

AbstractPiper laetispicum C. DC is one of the Chinese herbal medicines used for alleviating depressive disorders. G11‐5 [3‐(3, 4‐methylenedioxy‐5‐trifluoromethyl phenyl)‐2E‐propenoic acid isobutyl amide] is synthesized based on the chemical structure of an active integrant of Piper laetispicum C. DC. The present study assessed the antidepressant effect of G11‐5 and investigated the underlying mechanism with learned helplessness (LH) and social defeat stress (SDS) mice model of depression. In the LH model, mice were exposed to 60 inescapable electric shocks once a day for three consecutive days followed by 2‐week drug administration and helpless behaviour assessment. In the SDS model, mice were subjected to repeated social defeat by an aggressive CD‐1 mouse once a day for consecutive 10 days. Following oral administration for 2 weeks, the mice were subjected to a series of behavioural tests including social interaction test. G11‐5 significantly decreased the number of escape failures induced by LH paradigm, meanwhile increased the social interaction ratio and shortened the immobility time in forced swimming test for the SDS‐exposed mice, suggesting remarkable antidepressant effect. Moreover, G11‐5 ameliorated the changes in mitophagy‐related proteins induced by two stress exposures and restored retrograde axonal transport and neurotransmitter release. Our findings suggested that G11‐5 exhibited an obvious antidepressant through TSPO‐mediated mitophagy pathway.
Acute myeloid leukemia with NPM1 mutation and favorable European LeukemiaNet category: outcome after preemptive intervention based on measurable residual disease
Authors: Bataller Alex , Oñate Guadalupe , Diaz‐Beyá Marina , Guijarro Francesca , Garrido Ana , Vives Susana , Tormo Mar , Arnan Montserrat , Salamero Olga , Sampol Antònia , Coll Rosa , Vall‐Llovera Ferran , Oliver‐Caldés Aina , López‐Guerra Mònica , Pratcorona Marta , Zamora Lurdes , Villamon Eva , Roué Gaël , Blanco Adoración , Nomdedeu Josep F. , Colomer Dolors , Brunet Salut , Sierra Jorge , Esteve Jordi ,   Grupo Cooperativo Para el Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias (CETLAM)
Published: June 2020

SummaryIn the European LeukemiaNet favourable risk category, allogeneic haematopoietic stem cell transplantation (alloSCT) is not indicated in first complete remission for patients with acute myeloid leukaemia (AML) with NPM1 mutations (ELNfav NPM1 AML), although a proportion of these patients will relapse. Given the prognostic importance of measurable residual disease (MRD), CETLAM‐12 considered a pre‐emptive intervention in patients with molecular failure (MF). We analyzed 110 ELNfav NPM1 AML patients achieving complete remission (CR) after induction chemotherapy. Two‐year cumulative incidence of relapse (CIR), overall survival (OS) and leukaemia‐free survival (LFS) were 17%, 81·5% and 82%, respectively. Forty‐six patients required additional therapy for MF (n = 33) or haematological relapse (HemR; n = 13), resulting in a molecular LFS (molLFS) and a cumulative incidence of MF at two years of 61% and 38% respectively. Two‐year OS for these 46 patients was 66%, with a different outcome between patients with MF (86%) and HemR (42%) (P = 0·002). Quantitative NPM1 detection at different timepoints was predictive of molLFS; an MRD ratio (NPM1mut/ABL1 × 100) cut‐off of 0·05 after first consolidation identified two cohorts with a two‐year molLFS of 77% and 40% for patients below and above 0·05, respectively. In conclusion, MRD‐based pre‐emptive intervention resulted in a favourable outcome for ELNfav NPM1 AML patients.
R&D Information sharing in a mixed duopoly and incentive subsidy for research joint venture competition
Authors: Lee Sang‐Ho , Muminov Timur K. 
Published: June 2020

AbstractThis study investigates the incentives for R&D (research and development) information sharing in a mixed duopoly and finds a contrasting result that public firm chooses full sharing while private firm enjoys free‐riding. We then devise an agreement‐based incentive R&D subsidy scheme for RJV (research joint venture) competition, which can internalize R&D spillovers between firms and induce them to earn higher payoffs through full sharing of their R&D information. We also discuss welfare loss of the proposed R&D subsidy scheme, compare with production subsidy and provide some policy‐relevant implications on privatization.
Buyer power, product assortment and asymmetric retail formats
Authors: Fauli‐Oller Ramon , Sandonís Joel 
Published: June 2020

AbstractWe consider two manufacturers producing two symmetric and independent goods. They sell them through two undifferentiated retailers (homogeneous retailers). Manufacturers propose linear contracts. Before supply contracts are set by producers, retailers decide whether to be a multi‐product retailer by carrying the two goods or a single product retailer and sell only one good. In this symmetric setting, we find asymmetric retail formats in equilibrium, which results in lower total welfare compared to a situation where both retailers would be multi‐product retailers.
High‐dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy
Authors: Fourcade Stéphane , Goicoechea Leire , Parameswaran Janani , Schlüter Agatha , Launay Nathalie , Ruiz Montserrat , Seyer Alexandre , Colsch Benoit , Calingasan Noel Ylagan , Ferrer Isidre , Beal M. Flint , Sedel Frédéric , Pujol Aurora 
Published: June 2020

AbstractBiotin is an essential cofactor for carboxylases that regulates the energy metabolism. Recently, high‐dose pharmaceutical‐grade biotin (MD1003) was shown to improve clinical parameters in a subset of patients with chronic progressive multiple sclerosis. To gain insight into the mechanisms of action, we investigated the efficacy of high‐dose biotin in a genetic model of chronic axonopathy caused by oxidative damage and bioenergetic failure, the Abcd1− mouse model of adrenomyeloneuropathy. High‐dose biotin restored redox homeostasis driven by NRF‐2, mitochondria biogenesis and ATP levels, and reversed axonal demise and locomotor impairment. Moreover, we uncovered a concerted dysregulation of the transcriptional program for lipid synthesis and degradation in the spinal cord likely driven by aberrant SREBP‐1c/mTORC1signaling. This resulted in increased triglyceride levels and lipid droplets in motor neurons. High‐dose biotin normalized the hyperactivation of mTORC1, thus restoring lipid homeostasis. These results shed light into the mechanism of action of high‐dose biotin of relevance for neurodegenerative and metabolic disorders.