bluuebunny/crossref_metadata_2025_split huggingface dataset:
Justicia restaurativa y mediación penal en mujeres. Efectos en la normalización social
Authors: García Martínez Jesús , Ramos Parra César , Ramos Urdaneta Betty 
Published: December 2020

Este artículo pretende poner en valor la necesidad de una atención más especializadaÂ hacia la mujer desde el paradigma de la justicia restaurativa. El objetivo consiste en analizar el proceso de la mediación penal entreÂ víctima yÂ victimario desde un enfoque de género, evidenciando la relación entre mediación y reinserción social. El diseño de investigación es no experimental, de carácter documental, con un tipo de estudio descriptivo, empleando como técnica el análisis de las medidas judiciales de los juzgados de Aragón (España) en el lapso 2009-2013. Los resultados muestran cómo la mujer es la principal víctima en la comisión de los delitos, de ahí la necesidad de aplicar medidas de mediación para la reparación de la víctima y para la resocialización del infractor. Se busca la solución del conflicto ”“comisión del delito- y sus consecuencias en la que los protagonistas sean las partes, víctima y victimario, y donde la intervención judicial se articula como garante de los derechos procesales.
Remesas como fuente de desarrollo: Un estudio bibliométrico
Authors: Sainz Fernández Isabel , Torre Olmo María Begoña , López-Gutiérrez Carlos , Sanfilippo Azofra Sergio 
Published: December 2020

La importancia que las remesas han adquirido en la economía de los países receptores, sobre todo en losÂ países en desarrollo, ha atraído la atención de los investigadores. El objetivo a desarrollar a través delÂ presente artículo consiste en analizar la producción científica centrada en el estudio de las remesas comoÂ fuente de desarrollo, mediante un estudio bibliométrico, técnica que permite realizar un análisis cuantitativoÂ de las publicaciones científicas, para el periodo 1900-2011, plasmando los resultados mediante el uso deÂ redes sociales. Los hallazgos encontrados muestran cuatro líneas de investigación claramente definidas,Â como son los efectos de las remesas sobre la pobreza, la desigualdad y el desarrollo; los determinantes de lasÂ remesas; los efectos sobre la balanza de pagos y los efectos sobre la inversión en microempresas. El análisisÂ realizado permite obtener conclusiones desde una doble perspectiva: la clasificación de las principales líneasÂ de investigación y la identificación de futuras líneas que pueden servir de guía para los investigadores.
Políticas liberales y bienestar social en México (1983-2012)
Authors: Mora - Heredia Alfredo , Flores - Ruiz David , Barroso - González María de la O 
Published: December 2020

El presente artículo analiza las políticas liberales implementadas en México en los últimos 30 años (19832012), así como la evolución del bienestar social; con el fin de reflexionar sobre la contribución de esteÂ tipo de política económica en el desarrollo económico del país. Para ello, se sigue una investigaciónÂ descriptiva - analítica sobre las políticas y las condiciones socioeconómicas que se han venido sucediendo Â a lo largo de este periodo. Así, en primer lugar, a partir de un análisis bibliográfico, se caracteriza este tipoÂ de política económica para, posteriormente, analizar la evolución que han experimentado durante estasÂ tres décadas, los principales indicadores económicos y sociodemográficos del país. La construcción de unaÂ serie de indicadores se realiza consultando bases de datos de instituciones nacionales e internacionales. DeÂ forma, que los resultados ponen de manifiesto como los valores que toman los principales indicadores seÂ han deteriorado, excepto algunos de tipo económico como el déficit público y la inflación. Por todo ello, seÂ concluye que las políticas liberales no han contribuido ni a estabilizar el crecimiento económico ni a mejorarÂ los niveles de bienestar social del país durante estos años.
La planificación latinoamericana de la década de los 90.
Authors: Guillezeau Patricia 
Published: December 2020

Â El propósito del artículo es establecer algunas consideraciones teóricas sobre los modelos de planificación utilizados en la década de los noventa por los países latinoamericanos, a fin de determinar su funcionamiento y pertinencia en los procesos de cambio que vive el mundo. Para lograr el objetivo se aplica la metodología de investigación documental. Se realiza una revisión bibliográfica con la finalidad de establecer un conjunto de significados, teorías y conceptos que sirvieran de so- porte a la investigación. Se presentan y analizan algunas experiencias de países latinoamericanos, con el objeto de construir un conjunto de fundamentos teórico ”“ conceptuales que permitieran con la conjugación de los datos recabados dar respuesta al objetivo planteado. Del análisis se obtiene como conclusión la imperiosa necesidad de producir nuevas estrategias que normen, conduzcan y evalúen el proceso planificador y de gestión de forma integral, atendiendo a variables económicas, sociales, políticas, pero también las ambientales. Este esfuerzo de una forma racional contribuirá en la construcción del camino hacia un desarrollo sustentable e igualitario para todos los países de Latinoamérica.
Концентрація розчинного ST2 у плазмі крові та дисфункція серця в пацієнтів з есенціальною гіпертензією
Authors: Bahrij D. A. , Starzhynska O. L. , Zhebel V. M. 
Published: December 2020

The aim – to determine the place of soluble ST2 (sST2) as a possible biomarker of remodeling and heart dysfunction in patients with essential hypertension of varying severity.Materials and methods. Examined 150 men with confirmed essential hypertension (EН) of varying severity, including 50 people with EН complicated by heart failure (HF) IIA stage according to the classification of UAHF (groups were representative by age, mean age 50.17±0.48 y.о.), 70 men in the control group (mean age 48.82±0.78 y.о.) The following inclusion criteria were used: age 40 to 60 years, male, verified diagnosis of EH. The structure and function of the heart were studied using echocardiography with Doppler. The serum level of sST2 was determined by immuno assay.Results and discussion. The serum level of sST2 in patients of the control group was 22.14±0.86 ng/ml. It was found, that the peptide concentration in plasma of male patients without cardiovascular disease does not significantly correlate with physical or age parameters, renal function, the condition of systemic or intracardiac hemodynamics. It was found, that for patients with EH the serum level of sST2 was significantly higher than in the control group (p<0.05). The formation of left ventricular hypertrophy (LVH) leads to a significant increase of the peptide concentration in plasma in patients with EH. However, in patients with different types of LVH – concentric and eccentric – the indicator does not differ significantly (26.87±1.04 ng/ml vs. 29.15±1.15 ng/ml, p≥0.05). It was determined, that in case of confirmed diastolic dysfunction (DD) without LVH, the level of the peptide does not increase significantly. And only in patients with a combination of DD and LVH the serum level of sST2 is significantly higher (27.64±1.17 ng/ml, p≥0.05). Also in patients with EH and left ventricular ejection fraction (LV EF) less than 40 %, the serum level of peptide is significantly higher, than in patients with preserved LV EF (25.65±1.14 ng/ml vs. 29.07±1.22 ng/ml, p≥0.01).Conclusions. Thus, in male patients with EH of varying severity, the serum level of sST2 is significantly higher than in people without cardiovascular disease. Peptide concentration in plasma in both cases is not related to age or physical parameters. In patients with uncomplicated EH, significantly higher serum level of sST2 ​​is associated with the development of LVH, regardless of its type, and impaired diastolic function of the heart. In case of HF on the background of EH, the serum level of sST2 also is significantly higher, especially in case of the formation of systolic heart dysfunction with LV FE < 40 %.
Неспецифічний аортоартеріїт (хвороба Такаясу)
Authors: Isayeva G. S. , Trypilka S. A. 
Published: December 2020

The article presents a clinical case of Takayasu’s disease (nonspecific aortoarteritis). On the example of the course of the disease in a young woman, the features of clinical symptoms and diagnostic difficulties are analyzed. Particular attention is paid to the visualization of vascular lesions and the assessment of the dynamics of changes in the vessels as the disease progresses. Changes in laboratory parameters are presented in details according with ongoing therapy. The analysis of literature data of the effectiveness of drug therapy for the disease was carried out. It is emphasized that there is a very limited number of quality placebo-controlled studies in the literature. The practicing physician can only rely on the results of observational studies in his decision’s making process. Also, all studies presented in the literature included a very small number of patients. The algorithm of therapy prescription is given, the first line of which is glucocorticoids. Although there are very few literature data, it is noted that the achievement of remission with isolated glucocorticoid therapy is observed in 50 % of patients. According to the updated EULAR recommendations, after disease verification, therapy should be initiated immediately, the recommended starting dose is 40–60 mg of prednisolone (or equivalent). After achieving control of the disease, it is recommended to gradually reduce the dose to the target 15–20 mg/day for 2 to 3 months after 1 year to 10 mg/day. The next step is to prescribe a non-glucocorticoid immunosuppressant in order to provide both a «steroid sparing» effect and long-term control under the disease. All available information on the efficacy of methotrexate, mycophenolate mofetil, cyclophosphophomide, leflunamide, and azathioprine comes from open-label prospective or retrospective studies with a limited number of participants. Tumor necrosis factor inhibitors and tocilizumab are recommended as second-line drugs. A satisfactory clinical and laboratory response was observed in more than 80 % of patients receiving tocilizumab therapy. In this clinical case, tocilizumab was used and the effects of the drug during treatment for 8 months are described in detail. Immunobiological therapy with tocilizumab was associated with a good clinical and laboratory response, a decrease in vascular stenosis, and an improvement in the patient’s well-being.
DEVELOPMENT OF HUMAN RESOURCES QUALITY THROUGH IMPLEMENTATION OF ACADEMIC INFORMATION SYSTEMS FOR EDUCATION AND TRAINING PARTICIPANTS AT MARITIME HIGHER EDUCATION (STIP) JAKARTA
Authors: Sawitri Wulandari Rr. Retno , Selasdini Vidya , Sulistya Kurniawan Didik 
Published: December 2020

Maritime higher education, as a higher education institution in the shipping sector, is directed to produce professional and reliable graduates in the shipping sector who meet national and international standards and can compete in the global market. The application of competency-based education for vocational education is a government decision, in this case, the Ministry of Research, Technology, and Higher Education, as an effort to improve the quality of education and for vocational education based on the Manila amendment of STCW 2010. Many things can be done with information systems such as the academic information system for Maritime higher education seafarers 'education and training, which regulates the registration process, data on learning schedules, teaching, lecturers, training participants, and training participants' scores, to the stamp book process. The Seafarers' Education and Training Academic Information System gave a role of 61.41% to training participants in the Maritime higher education Jakarta environment, and other roles influenced 38.59%. The information system will also make it very easy for Maritime higher education to produce the information related above and facilitate all Maritime higher education activities related to data management.
DETERMINASI KEPUASAN KERJA DAN KINERJA KARYAWAN MOTIVASI, GAYA KEPEMIMPINAN (SEBUAH LITERATUR REVIEW MANAJEMEN SUMBER DAYA MANUSIA)
Authors: Runa Rahmat 
Published: December 2020

Sumber daya manusia merupakan salah satu unsur yang sangat penting bagi organisasi baik di perusahaan swasta maupun pemerintah. Untuk mencapai keberhasilan tujuan organisasi maupu individu diperlukan tatanan secara sistematis dan terstruktur yang diatur dalam sebuah pola manajemen organisasi. Salah satu upaya manajemen sumber daya manusia yaitu pengendalian terhadap faktor-faktor yang signifikan mempengaruhi kinerja organisasi. Tujuan penulisan artikel ini adalah untuk mengetahui bagaimana hubungan dan sejauh mana pengaruh motivasi, gaya kepemimpinan, terhadap kepuasan kerja dan kinerja karyawan, yang merupakan suatu studi literatur dari berbagai penelitian sebelumnya yang dianggap relevan, agar dapat dijadikan bahan referensi bagi peneltian selanjutnya dibidang sumber daya manusia dalam menentukan strategi dan kebijakan sebuah organisasi.
Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study
Authors: Nozaki Shoko , Sawada Norie , Matsuoka Yutaka J. , Shikimoto Ryo , Mimura Masaru , Tsugane Shoichiro 
Published: December 2020

Background: The relationship between midlife dietary habits and risk of dementia remains unclear. Objective: To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life. Methods: This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45–64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA-rich fish, total n-3 PUFAs, total n-6 PUFAs, types of PUFAs, and n-3/n-6 PUFA ratio. Estimated ORs were adjusted for age; sex; education; smoking status; alcohol consumption frequency; physical activity; histories of cancer, myocardial infarction, and diabetes mellitus; and depression. Results: Significantly reduced risks of dementia over non-dementia (MCI plus cognitively normal) were observed in the second (OR = 0.43 (95% CI = 0.20–0.93)), third (OR = 0.22 (95% CI = 0.09–0.54)), and highest quartiles (OR = 0.39 (95% CI = 0.18–0.86)) for fish; the third (OR = 0.39 (95% CI = 0.16–0.92)) and highest quartiles (OR = 0.44 (95% CI = 0.19–0.98)) for eicosapentaenoic acid (EPA); the second (OR = 0.39 (95% CI = 0.18–0.84)), third (OR = 0.30 (95% CI = 0.13–0.70)), and highest quartiles (OR = 0.28 (95% CI = 0.12–0.66)) for docosahexaenoic acid (DHA); and the third (OR = 0.36 (95% CI = 0.16–0.85)) and highest quartiles (OR = 0.42 (95% CI = 0.19–0.95)) for docosapentaenoic acid (DPA). Conclusion: High intake of fish in midlife might aid in preventing dementia.
Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer’s Disease
Authors: Ryan Margaret , Tan Valerie T.Y. , Thompson Nasya , Guévremont Diane , Mockett Bruce G. , Tate Warren P. , Abraham Wickliffe C. , Hughes Stephanie M. , Williams Joanna 
Published: December 2020

Background: Secreted amyloid precursor protein-alpha (sAPPα) can enhance memory and is neurotrophic and neuroprotective across a range of disease-associated insults, including amyloid-β toxicity. In a significant step toward validating sAPPα as a therapeutic for Alzheimer’s disease (AD), we demonstrated that long-term overexpression of human sAPPα (for 8 months) in a mouse model of amyloidosis (APP/PS1) could prevent the behavioral and electrophysiological deficits that develop in these mice. Objective: To explore the underlying molecular mechanisms responsible for the significant physiological and behavioral improvements observed in sAPPα-treated APP/PS1 mice. Methods: We assessed the long-term effects on the hippocampal transcriptome following continuous lentiviral delivery of sAPPα or empty-vector to male APP/PS1 mice and wild-type controls using Affymetrix Mouse Transcriptome Assays. Data analysis was carried out within the Affymetrix Transcriptome Analysis Console and an integrated analysis of the resulting transcriptomic data was performed with Ingenuity Pathway analysis (IPA). Results: Mouse transcriptome assays revealed expected AD-associated gene expression changes in empty-vector APP/PS1 mice, providing validation of the assays used for the analysis. By contrast, there were specific sAPPα-associated gene expression profiles which included increases in key neuroprotective genes such as Decorin, betaine-GABA transporter and protocadherin beta-5, subsequently validated by qRT-PCR. An integrated biological pathways analysis highlighted regulation of GABA receptor signaling, cell survival and inflammatory responses. Furthermore, upstream gene regulatory analysis implicated sAPPα activation of Interleukin-4, which can counteract inflammatory changes in AD. Conclusion: This study identified key molecular processes that likely underpin the long-term neuroprotective and therapeutic effects of increasing sAPPα levels in vivo
An Exploratory Study of the Development and Pilot Testing of an Interactive Visual Tool of Neuropsychological Test Results in Memory Clinics
Authors: Gruters Angélique A.A. , Ramakers Inez H.G.B. , Stiekema Annemarie P.M. , Verhey Frans R.J. , Kessels Roy P.C. , de Vugt Marjolein E. 
Published: December 2020

Background: Neuropsychological feedback is an important part of the neuropsychological assessment process. However, patients have difficulties remembering this information. Objective: The aim of this study was to develop a web-based visual tool to improve the understanding of neuropsychological results, information retention, and psychologist-patient communication. Methods: The visual tool was developed and optimized using an iterative three-phase stepwise approach to determine its usability, technology acceptance, and feasibility in a memory clinic population. Feedback from different user perspectives (patients, family members, and psychologists) was obtained in each phase using a multimethod approach (e.g. a multidisciplinary brainstorm session, think-aloud sessions, focus groups). The prototype was subsequently tested in a pilot study. Results: The first phases offered insights that led to optimization of the prototype. On a scale ranging from 0 to 100, psychologists evaluated the usability as high [88.1±7.6,70–87]. During the pilot study, both patients and significant others gave positive feedback, but information retention in patients remained low. All participants thought the benefits of the visual tool included seeing cognitive strengths and weaknesses with a translation to daily life all at one glance and receiving feedback on paper to take home. Important barriers were mentioned by psychologists, such as a limited set of tests included and no integration with hospital systems. Conclusion: Overall, patients, family members, and psychologists reported that a visual display of the cognitive profile with insights into daily life had added value to clinical practice. Feedback from the pilot study was adopted in the tool for future implementation purposes.
An Automatic Method for Interest Point Detection
Authors: Zubov I. G. 
Published: December 2020

Introduction. Computer vision systems are finding widespread application in various life domains. Monocularcamera based systems can be used to solve a wide range of problems. The availability of digital cameras and large sets of annotated data, as well as the power of modern computing technologies, render monocular image analysis a dynamically developing direction in the field of machine vision. In order for any computer vision system to describe objects and predict their actions in the physical space of a scene, the image under analysis should be interpreted from the standpoint of the basic 3D scene. This can be achieved by analysing a rigid object as a set of mutually arranged parts, which represents a powerful framework for reasoning about physical interaction.Objective. Development of an automatic method for detecting interest points of an object in an image.Materials and methods. An automatic method for identifying interest points of vehicles, such as license plates, in an image is proposed. This method allows localization of interest points by analysing the inner layers of convolutional neural networks trained for the classification of images and detection of objects in an image. The proposed method allows identification of interest points without incurring additional costs of data annotation and training.Results. The conducted experiments confirmed the correctness of the proposed method in identifying interest points. Thus, the accuracy of identifying a point on a license plate achieved 97%.Conclusion. A new method for detecting interest points of an object by analysing the inner layers of convolutional neural networks is proposed. This method provides an accuracy similar to or exceeding that of other modern methods.
Bioinformatics Analysis of Key micro-RNAs and mRNAs under the Hand, Foot, and Mouth Disease Virus Infection
Authors: LIN SHENG , YANG LIU , WANG SHIBIAO , WENG BIN , LIN MIN 
Published: December 2020

Abstract
To clarify crucial key micro-RNAs and mRNAs associated with hand, foot, and mouth disease (HFMD) virus infection, we conducted this bioinformatics analysis from four GEO datasets. The following datasets were used for the analysis: GSE85829, GSE94551, GSE52780, and GSE45589. Differentially expressed genes (DEGs) were acquired, and the analysis of functional and pathway enrichment and the relative regulatory network were conducted. After screening common differentially expressed miRNAs (DE-miRNAs), five key miRNAs were acquired: miR-100-3p, miR-125a-3p, miR-1273g-3p, miR-5585-3p, and miR-671-5p. There were three common enriched GO terms between miRNA-derived prediction and mRNA-derived analysis: biosynthetic process, cytosol, and nucleoplasm. There was one common KEGG pathway, i.e., cell cycle shared between miRNA-based and mRNA-based enrichment. Using TarBase V8 in DIANA tools, we acquired 1,520 potential targets (mRNA) from the five key DE-miRNAs, among which the159 DE-mRNAs also included 11 DEGs. These common DEGs showed a PPI network mainly connected by SMC1A, SMARCC1, SF3B3, LIG1, and BRMS1L. Together, changes in five key miRNAs and 11 key mRNAs may play crucial roles in HFMD progression. A combination of these roles may benefit the early diagnosis and treatment of HFMD.