bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between sleep quality and time with energy metabolism in sedentary adults
Authors: Jurado-Fasoli Lucas , Mochon-Benguigui Sol , Castillo Manuel J. , Amaro-Gahete Francisco J. 
Published: March 2020

AbstractThe aim of the present study was to investigate the relationship of sleep quality and time with basal metabolic rate (BMR) and fuel oxidation in basal conditions and during exercise in sedentary middle-aged adults. We also studied the mediation role of dietary intake and adherence to the traditional Mediterranean Diet in the relationship between sleep parameters and energy metabolism parameters.A secondary analysis of the FIT-AGEING study was undertaken. 70 middle-aged sedentary adults (40–65 years old) participated in the present study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and wrist accelerometers (ActiSleep, Actigraph, Pensacola, Florida, USA) for 7 consecutive days. BMR was measured with indirect calorimetry and fuel oxidation was estimated through stoichiometric equations. Maximal fat oxidation was determined by a walking graded exercise test and dietary intake with 24 h recalls. Adherence to the traditional Mediterranean diet was assessed through the PREDIMED questionnaire. PSQI global score (poor sleep quality) was associated with lower basal fat oxidation (BFox), both expressed in g/min and as a percentage of BMR, independently of confounders. We did not find any association between other sleep and energy metabolism parameters. No mediating role of the dietary intake or PREDIMED global score was observed in the association of PSQI and BFox. In conclusion, our study showed that a subjective poor sleep quality was associated with lower BFox, which is not mediated by dietary intake in sedentary adults.
COMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis
Authors: Li Jiang , Kho Alvin T. , Chase Robert P. , Pantano Lorena , Farnam Leanna , Amr Sami S. , Tantisira Kelan G. 
Published: March 2020

AbstractSmall RNA-Seq is a common means to interrogate the small RNA’ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identifying and quantifying the small RNA’ome constituent components. For example, small RNAs in the circulatory system (circulating RNAs) are potential disease biomarkers and their function is being actively investigated. Most existing NGS data analysis tools focus on the microRNA component and a few other small RNA types like piRNA, snRNA and snoRNA. A comprehensive platform is needed to interrogate the full small RNA’ome, a prerequisite for down-stream data analysis. We present COMPSRA, a comprehensive modular stand-alone platform for identifying and quantifying small RNAs from small RNA sequencing data. COMPSRA contains prebuilt customizable standard RNA databases and sequence processing tools to enable turnkey basic small RNA analysis. We evaluated COMPSRA against comparable existing tools on small RNA sequencing data set from serum samples of 12 healthy human controls, and COMPSRA identified a greater diversity and abundance of small RNA molecules. COMPSRA is modular, stand-alone and integrates multiple customizable RNA databases and sequence processing tool and is distributed under the GNU General Public License free to non-commercial registered users at https://github.com/cougarlj/COMPSRA.
Elevated resting heart rate is associated with several cardiovascular disease risk factors in urban-dwelling black South Africans
Authors: Peer N. , Lombard C. , Steyn K. , Levitt N. 
Published: March 2020

AbstractThis study determined the associations of resting heart rate (RHR) with cardiovascular disease risk factors (CVDRF) in 25–74-year-old black South Africans. This cross-sectional study determined CVDRF by administered questionnaires, clinical measurements and biochemical analyses, including oral glucose tolerance tests. Multivariable linear regression models determined the associations of rising RHR with CVDRF. The basic model comprised age, gender, urbanisation, problematic alcohol use, daily cigarette smoking, physical activity and waist circumference. Glucose, blood pressure and cholesterol variables were entered separately and individually in the above model. Among the 1054 participants (382 men and 672 women, mean age 42.8 years), mean RHR was 70.6 beats per minute (bpm) and significantly higher in women (73.6 bpm) compared with men (65.3 bpm). RHR peaked in 45–54-year-old men (69.3 bpm) and 25–34-year-old women (75.3 bpm). Prevalence of RHR < 60 bpm and ≥90 bpm was 24.3% and 6.2%. In the regression model, female gender, problematic alcohol use, decreasing physical activity and increasing waist circumference were significantly associated with rising RHR. All glycaemic variables (diabetes, fasting glucose and 2-hour glucose) and diastolic blood pressure were significantly associated with RHR. The use of RHR in daily primary healthcare settings to identify increased risk for CVDRF should perhaps be encouraged.
Tuning the Superhydrophobic Properties of Hierarchical Nano-microstructural Silica Biomorph Arrays Grown at Triphasic Interfaces
Authors: Xiang Xu-Fu , Li Peng-Jie , Liu Bi-Feng 
Published: March 2020

AbstractThe three-dimensional hierarchical morphology of surfaces greatly affects the wettability, absorption and microfabrication properties of their hybrid materials, however few scalable methods exist that controls simultaneously complex geometric shape and spatial scattered location and their physical properties tuned. Consequently, this report describes a synthetic strategy that enables the position of well-ordered biomorph nano-microstructures on hydrophobic surfaces to be precisely controlled. The hierarchical architecture can be accurately positioned on polydimethylsiloxane (PDMS) surfaces in an unprecedented level by leveraging a solid/liquid/gas triphase dynamic reaction diffusion system strategy. The effect of salt concentrations, pH, CO2 levels, temperature and substrate patterning on this self-assembly process has been investigated, enabling protocols to be devised that enables the hydrophobic properties of the hierarchically assembled multiscale microstructures to be tuned as required. This combined top-down/bottom-up approach can be used to produce composites with outstanding hydrophobicity properties, affording superhydrophobic materials that are capable of retaining water droplets on their surfaces, even when the material is inverted by 180°, with a wide range of potential applications in oil/water separation technology and for selective cell recognition in biological systems.
Benchtop-fabricated lipid-based electrochemical sensing platform for the detection of membrane disrupting agents
Authors: Saem Sokunthearath , Shahid Osama , Khondker Adree , Moran-Hidalgo Camila , Rheinstädter Maikel C. , Moran-Mirabal Jose 
Published: March 2020

AbstractThere are increasing concerns about the danger that water-borne pathogens and pollutants pose to the public. Of particular importance are those that disrupt the plasma membrane, since loss of membrane integrity can lead to cell death. Currently, quantitative assays to detect membrane-disrupting (lytic) agents are done offsite, leading to long turnaround times and high costs, while existing colorimetric point-of-need solutions often sacrifice sensitivity. Thus, portable and highly sensitive solutions are needed to detect lytic agents for health and environmental monitoring. Here, a lipid-based electrochemical sensing platform is introduced to rapidly detect membrane-disrupting agents. The platform combines benchtop fabricated microstructured electrodes (MSEs) with lipid membranes. The sensing mechanism of the lipid-based platform relies on stacked lipid membranes serving as passivating layers that when disrupted generate electrochemical signals proportional to the membrane damage. The MSE topography, membrane casting and annealing conditions were optimized to yield the most reproducible and sensitive devices. We used the sensors to detect membrane-disrupting agents sodium dodecyl sulfate and Polymyxin-B within minutes and with limits of detection in the ppm regime. This study introduces a platform with potential for the integration of complex membranes on MSEs towards the goal of developing Membrane-on-Chip sensing devices.
Synchrotron radiation imaging analysis of neural damage in mouse soleus muscle
Authors: Lee Jiwon , Jang Sang-Hun , Lee Suk-Jun , Lee Onseok 
Published: March 2020

AbstractDamage to lower limb muscles requires accurate analysis of the muscular condition via objective microscopic diagnosis. However, microscopic tissue analysis may cause deformation of the tissue structure due to injury induced by external factors during tissue sectioning. To substantiate these muscle injuries, we used synchrotron X-ray imaging technology to project extremely small objects, provide three-dimensional microstructural analysis as extracted samples. In this study, we used mice as experimental animals to create soleus muscle models with various nerve injuries. We morphologically analyzed and quantified the damaged Section and Crush muscles, respectively, via three-dimensional visualization using synchrotron radiation X-ray imaging to diagnose muscle injury. Results of this study can also be used as basic data in the medical imaging field.
Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis
Authors: Kim Ye-Ram , Kim Jae-Sung , Gu Su-Jin , Jo Sungsin , Kim Sojin , Young Kim Sun , Lee Daeun , Jang Kiseok , Choo Hyunah , Kim Tae-Hwan , Jung Jae U. , Min Sun-Joon , Yang Chul-Su 
Published: March 2020

AbstractRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease linked to oxidative stress, which is associated with significant morbidity. The NADPH oxidase complex (NOX) produces reactive oxygen species (ROS) that are among the key markers for determining RA’s pathophysiology. Therefore, understanding ROS-regulated molecular pathways and their interaction is necessary for developing novel therapeutic approaches for RA. Here, by combining mouse genetics and biochemistry with clinical tissue analysis, we reveal that in vivo Rubicon interacts with the p22phox subunit of NOX, which is necessary for increased ROS-mediated RA pathogenesis. Furthermore, we developed a series of new aryl propanamide derivatives consisting of tetrahydroindazole and thiadiazole as p22phox inhibitors and selected 2-(tetrahydroindazolyl)phenoxy-N-(thiadiazolyl)propanamide 2 (TIPTP, M.W. 437.44), which showed considerably improved potency, reaching an IC50 value up to 100-fold lower than an inhibitor that we previously synthesized reported N8 peptide-mimetic small molecule (blocking p22phox–Rubicon interaction). Notably, TIPTP treatment showed significant therapeutic effects a mouse model for RA. Furthermore, TIPTP had anti-inflammatory effects ex vivo in monocytes from healthy individuals and synovial fluid cells from RA patients. These findings may have clinical applications for the development of TIPTP as a small molecule inhibitor of the p22phox-Rubicon axis for the treatment of ROS-driven diseases such as RA.
Direct evidence of weakly dispersed and strongly anharmonic optical phonons in hybrid perovskites
Authors: Ferreira A. C. , Paofai S. , Létoublon A. , Ollivier J. , Raymond S. , Hehlen B. , Rufflé B. , Cordier S. , Katan C. , Even J. , Bourges P. 
Published: March 2020

AbstractHybrid organolead perovskites (HOP) have started to establish themselves in the field of photovoltaics, mainly due to their great optoelectronic properties and steadily improving solar cell efficiency. Study of the lattice dynamics is key in understanding the electron-phonon interactions at play, responsible for such properties. Here, we investigate, via neutron and Raman spectroscopies, the optical phonon spectrum of four different HOP single crystals: MAPbBr3, FAPbBr3, MAPbI3, and α-FAPbI3. Low temperature spectra reveal weakly dispersive optical phonons, at energies as low as 2-5 meV, which seem to be the origin of the limit of the charge carriers mobilities in these materials. The temperature dependence of our neutron spectra shows as well a significant anharmonic behaviour, resulting in optical phonon overdamping at temperatures as low as 80 K, questionning the validity of the quasi-particle picture for the low energy optical modes at room temperature where the solar cells operate.
Rydberg excitons in Cu2O microcrystals grown on a silicon platform
Authors: Steinhauer Stephan , Versteegh Marijn A. M. , Gyger Samuel , Elshaari Ali W. , Kunert Birgit , Mysyrowicz André , Zwiller Val 
Published: March 2020

AbstractCuprous oxide (Cu2O) is a semiconductor with large exciton binding energy and significant technological importance in applications such as photovoltaics and solar water splitting. It is also a superior material system for quantum optics that enabled the observation of intriguing phenomena, such as Rydberg excitons as solid-state analogue to highly-excited atomic states. Previous experiments related to excitonic properties focused on natural bulk crystals due to major difficulties in growing high-quality synthetic samples. Here, the growth of Cu2O microcrystals with excellent optical material quality and very low point defect levels is presented. A scalable thermal oxidation process is used that is ideally suited for integration on silicon, demonstrated by on-chip waveguide-coupled Cu2O microcrystals. Moreover, Rydberg excitons in site-controlled Cu2O microstructures are shown, relevant for applications in quantum photonics. This work paves the way for the wide-spread use of Cu2O in optoelectronics and for the development of novel device technologies.
Inhibiting MicroRNA-497 Improves the Effects of Exercise Training on
Myocardial Infarction
Authors: Li Zhenci , Lv Jing , Pan Yizhi , Luo Yi , Liu Zhen , Huang Jiankai , Wu Qi 
Published: March 2020

AbstractExercise training (ET) could improve myocardial infarction (MI), and microRNA-497
is highly associated with MI. This study aimed to investigate whether the
regulation of miR-497 is involved in the positive effects of ET on MI. MI rat
models induced by left anterior descending (LAD) were subjected to interval
training and infarct size was observed. Blood and myocardial samples were
collected from the rats for determining the expressions of miR-497. To evaluate
the functions of miR-497, miR-497 agomir and antagomir were injected accordingly
into grouped rats during ET, and subsequently, the expressions of apoptotic and
inflammatory factors were determined. ET reduced the infarct size in MI rats and
inhibited the levels of miR-497. MiR-497 agomir injection enlarged the infarct
size, and reversed the shrunk infarct size induced by ET. However, miR-497
antagomir further promoted the positive effect on MI improved by ET. Chloride
voltage-gated channel 3 (CLCN3) was identified as the most possible target for
miR-497. Moreover, ET improving MI also involved the regulation of apoptotic and
inflammatory factors. The mechanisms underlying the positive effects of ET on MI
were highly associated with the regulation of miR-497.
Die Bedeutung kognitiver Verzerrungen für die Diagnose einer pädosexuellen Präferenzstörung bei inhaftierten Tätern mit Sexualdelikten in Österreich
Authors: Eberhaut Sabrina , Briken Peer , Eher Reinhard 
Published: March 2020

Zusammenfassung
Einleitung Unter kindesmissbrauchsspezifischen kognitiv verzerrten Sichtweisen versteht man pathologische Wahrnehmungsverzerrungen, die es einem Täter ermöglichen, sexuelle Übergriffe auf Kinder zu bahnen und nach den Tathandlungen zu rechtfertigen. Zu diesen Verzerrungen zählen unter anderem die Annahmen, dass Kinder Sex mit Erwachsenen wünschen oder dass sexuelle Handlungen von Erwachsenen an Kindern diesen keinen Schaden zufügen.
Forschungsziele Zusammenhänge zwischen solchen Verzerrungen und dem Störungsbild einer Pädophilie wurden untersucht. Insbesondere verfolgten wir dabei die Hypothese, dass kognitive Verzerrungen Ausdruck eines klinischen Störungsbildes sind und nicht lediglich mit dem Umstand einhergehen, ein Kind sexuell zu missbrauchen.
Methoden Dafür wurde ein Fragebogen entwickelt, der N = 632 Tätern (davon N = 462 an Kindern) vorgelegt wurde, die in Österreich ein Sexualdelikt begangen hatten und deshalb eine Haftstrafe verbüßten. Die Täter wurden jeweils einer von insgesamt vier Gruppen zugeordnet (Sexualstraftäter mit erwachsenen Opfern, Kindesmissbrauchstäter ohne Diagnose einer Pädophilie, Kindesmissbrauchstäter mit nicht-ausschließlicher Pädophilie, Kindesmissbrauchstäter mit ausschließlicher Pädophilie). Die Ergebnisse wurden einer Faktorenanalyse unterzogen, die einzelnen Faktoren und der Gesamtwert auf Unterschiede zwischen den Tätergruppen überprüft.
Ergebnisse Die vorliegenden Daten legen den Schluss nahe, dass nicht der Umstand allein, ein Kind sexuell zu missbrauchen, mit solchen Verzerrungen einhergeht, sondern vielmehr die Diagnose einer pädophilen Störung. Insbesondere Personen mit der Diagnose einer ausschließlichen pädophilen Störung gaben derartige Kindesmissbrauchsmythen an. Vor allem Glaubenssätze, die aus psychodynamischer Sicht als Spaltung, Projektion und projektive Identifizierung der eigenen Devianz auf Kinder verstanden werden können, waren bei gegebener Diagnose einer exklusiven pädophilen Störung am stärksten ausgeprägt.
Schlussfolgerung Wahrnehmungsverzerrungen können als Abwehrmechanismen einer pädophilen Störung verstanden werden, die auch zur Untermauerung der Diagnose dienen können.
Exzessive Gewichtszunahme in der Schwangerschaft und die prognostische Bedeutung des Apolipoprotein B
Authors: Bohlen Sophia-Marie , Eckmann-Scholz Christel , Rath Werner , Maass Nicolai , Pecks Ulrich 
Published: March 2020

ZusammenfassungEinleitung Exzessive Gewichtszunahme (EGZ) stellt einen Risikofaktor in der Schwangerschaft dar. Da die EGZ ebenso wie Hypertensive Schwangerschaftserkrankungen (HES) und die intrauterine Wachstumsrestriktion (IUGR) mit veränderten Konzentrationen Apolipoprotein B- (ApoB) haltiger Lipoproteine einhergehen, wurde der Hypothese nachgegangen, ob die ApoB-Konzentration im ersten Trimester diese Ereignisse vorhersagen kann.Methoden Von 547 Schwangeren zeigten 95 eine unzureichende, 171 eine empfohlene und 281 eine EGZ. 23 Schwangere wiesen eine HES, 67 ein small for gestational age (SGA) Neugeborenes und sieben eine IUGR auf. Die ApoB-Konzentration wurden mittels ELISA in Serum der 11+0 bis 13+6 SSW bestimmt.Ergebnisse Die mittleren ApoB-Konzentrationen der Patientinnen verschiedener Gewichtszunahme-Gruppen waren nicht signifikant unterschiedlich. Frauen mit Adipositas zeigten höhere ApoB-Konzentrationen als normalgewichtige (p<0,001). Patientinnen mit präexistentem Hypertonus sowie Raucherinnen wiesen erhöhte ApoB-Konzentrationen verglichen mit normotensiven Kontrollen (p=0,0015) und Nichtraucherinnen (p=0,0118) auf. Eine prognostische Bedeutung ließ sich in Bezug auf HES und IUGR/SGA nicht nachweisen.Folgerung Die ApoB-Konzentration im ersten Trimester ist nicht für die Vorhersage einer EGZ oder Schwangerschaftskomplikation geeignet. Bei bestehenden pathologischen Zuständen wie Rauchen, Adipositas und chronischer Hypertonie sind die ApoB-Werte erhöht und könnten in diesen Gruppen zur Pathogenese von Schwangerschaftserkrankungen beitragen.
Oral Rehabilitation of a Severely Resorbed Edentulous Maxilla with Screwed-retained Hybrid Denture Using Cresco System: A Case Report
Authors: Turkyilmaz Ilser , Patel Neal S. , McGlumphy Edwin A. 
Published: March 2020

ABSTRACTDue to the angulation of maxillary bone as the maxillary bone resorption occurs from a buccal to
palatal direction, bucco-lingually tilted implant placement is more likely especially in the posterior maxilla. The aim of this paper was to present a case restored by using a maxillary hybrid denture using Cresco method. A 59-year-old woman with an edentulous maxilla and five missing mandibular teeth was referred for implant treatment. Six months after sinus lift operation, four mandibular implants and six maxillary implants were placed. Due to the bucco-lingual tilt of two implants, the Cresco method was chosen to fabricate the metal framework for the maxillary hybrid denture that was delivered four months after implant placement. The main advantages of the Cresco method are a perfectly passive framework fit and corrected screw access holes. All ten implants placed were considered successful at 1-year recall, and no screw access holes were seen in the buccal part of the maxillary acrylic teeth.It was concluded that such screw-retained maxillary hybrid denture using the Cresco method met the esthetic expectations of a highly demanding patient. (Eur J Dent 2008;2:220-223)
Upper Airway Findings and Markers of Lung Disease Progression in Patients with Cystic Fibrosis
Authors: Steffen Luciane Mazzini , Pezzin Luise Sgarabotto , Sulis Natassia , Steffen Nedio , Pinto Leonardo Araujo 
Published: March 2020

Abstract
Introduction Cystic fibrosis (CF) is a genetic disease that limits the quality of life mainly due to respiratory symptoms. The relationship between findings of the upper airways and CF lung disease is not yet completely understood.
Objective The aim of the present study is to describe the most frequent nasal findings and pathogens in patients with CF and investigate the association between the findings of the upper respiratory tract and markers of lung disease progression.
Methods Retrospective study in patients with CF from the Pediatric Pulmonology Department who underwent otorhinolaryngological evaluation between 2015 and 2017. Nasal endoscopy and nasal swab collection were part of the evaluation. The severity markers used were: percentage of predicted forced expiratory volume in the first second (FEV1%), body mass index (BMI) and the Shwachman-Kulczycki (SK) clinical score.
Results A total of 48 patients with CF were included. The mean of the predicted percentage of FEV1% was 83.36 ± 30.04. The average 14 and SK score 89.11 ± 10.50. The bacteriology of the nasal swab was positive in 27 (54.1%) patients. Staphylococcus aureus was positive in 18 patients, Pseudomonas aeruginosa in 5, Pseudomonas cepacea in 3 and Stenotrophomonas maltophila in 1 patient. Nasal polyps were found in nine participants. Nasal polyps were found in nine participants and were associated with lower SK score.
Conclusion The pathogens found in the upper airway were, in order: S. aureus, P. aeruginosa, P. cepacea e S. maltophila. The presence of polyps in the nasal cavity showed statistical significance and appears to have association with the prognostic factor measured by the SK score.
Syntactic contrasts in early and late Brazilian Portuguese-European Portuguese bidialectal bilinguals
Authors: Castro Tammer , Rothman Jason , Westergaard Marit 
Published: March 2020

Abstract
This study explores the production of subject and object pronouns in the case of Brazilian Portuguese (BP) and European Portuguese (EP) early and late bidialectal bilinguals. The distribution of empty categories in the two systems differs in terms of syntactic and semantic constraints. In this light, we test the extent to which Brazilians acquiring EP naturalistically in Portugal display cross-linguistic effects. Our results indicate that cross-linguistic effects are found both in BP and EP for late learners, but only in BP for early learners. We believe that the high degree of typological proximity between BP and EP and the structural differences between subjects and objects can better explain these learners’ outcomes.