bluuebunny/crossref_metadata_2025_split huggingface dataset:
O APAGAMENTO DO SENTIDO JORNALÍSTICO DE CONSTRUÇÃO COLETIVA PELA INDIVIDUAÇÃO: “Obrigado por suas informações!”
Authors: Hagen Sean Aquere 
Published: January 2020

A personalização dos jornalistas nas entradas “ao vivo” em oposição ao sentido de jornalismo como construção coletiva está passando por um processo de naturalização nos telejornais da Rede Globo. Esta é uma postura conflitante com as finalidades do campo: amplifica o poder político creditado ao jornalismo ao personalizar, via enunciação, ações cotidianas intrínsecas da profissão; isso intensifica a credibilidade de empresas, jornais e jornalistas. Os pronomes possessivos, as conjugações verbais na primeira pessoa do singular e o adjetivo “obrigado” são as principais manifestações dessa prática, que vem crescendo nos últimos anos. Para desvelar esses sentidos, a amostragem qualitativa recaiu sobre o Jornal Hoje, Jornal Nacional e Jornal da Globo.

PALAVRAS-CHAVE: Telejornais; Construção coletiva; Personalização de jornalistas; Rede Globo.

ABSTRACT
The personalization of journalists in the “live” entries as opposed to the sense of journalism as a collective construction is undergoing a process of naturalization on Rede Globo newscasts. This posture conflicts with the purposes of the field: it amplifies the political power credited to journalism by personalizing, via enunciation, daily actions intrinsic to the profession to intensify the credibility that differentiates companies, newspapers and journalists. Possessive pronouns, verbal conjugations in the first person singular and the adjective "thank you" are the main manifestations of this practice, which has been growing in recent years. To unveil these meanings, the qualitative sampling fell on Jornal Hoje, Jornal Nacional and Jornal da Globo.

KEYWORDS: Newscast; Collective construction; Personalization of journalists; Rede Globo.

RESUMEN
La personalización de los periodistas en las entradas "en vivo" en oposición al sentido del periodismo como construcción colectiva está pasando por un proceso de naturalización en los telediarios de la Rede Globo. Esta postura entra en conflicto con los propósitos del campo: amplifica el poder político acreditado al periodismo al personalizar, a través de la enunciación, acciones cotidianas intrínsecas a la profesión; esto intensifica la credibilidad de las empresas, los periódicos y los periodistas. Los pronombres posesivos, las conjugaciones verbales en primera persona singular y el adjetivo "gracias" son las principales manifestaciones de esta práctica, que ha ido creciendo en los últimos años. Para desvelar estos significados, el muestreo cualitativo se realizó en el Jornal Hoje, el Jornal Nacional y el Jornal da Globo.

PALABRAS CLAVE: Telediarios; Construcción colectiva; Personalización de periodistas; Rede Globo.
Long intergenic non-coding RNA 1939 inhibits proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154
Authors: Zhang Rongyuan , Huang Yuhua , Xu Baocai , Lv Chuan , Hou Jianquan , Zhang Weijie 
Published: January 2020

Abstract
The authors have withdrawn the journal submission associated with this preprint and requested that the preprint also be withdrawn.
Development of a clinical prediction model of chronic kidney disease in primary Focal Segmental Glomerulosclerosis
Authors: Ossareh Shahrzad , Yahyaei Mansoureh , Asgari Mojgan , Afghahi Hanri 
Published: January 2020

Abstract
Background: Focal segmental glomerulosclerosis (FSGS) is one of the important causes of end stage kidney disease (ESKD). We evaluated the risk factors of progression of primary FSGS to chronic kidney disease (CKD) or ESKD with a predictive model including clinical and histological predictors. Methods: 201 patients with primary FSGS (59% male, mean age: 38±15 years), were studied. Time-dependent Cox model and C statistics were used for the predictive model. Interaction and correlation between independent variables were estimated. Results: During 55±27 months of follow-up, 82 patients (41%) developed CKD (46) or ESKD (36) patients. In adjusted model, 1 unit of higher serum creatinine (SCr) at baseline (HR:1.39, 95%CI: 1.15-1.70) and 1% increase in glomeruli with segmental glomerulosclerosis (SGS) (HR: 1.03, 95% CI: 1.02-1.04) or interstitial fibrosis/tubular atrophy (IF/TA) (HR: 1.03, 95% CI: 1.01-1.05) increased the risk of CKD/ESKD. In adjusted model, higher baseline proteinuria and collapsing variant were not associated with risk of CKD/ESKD. By adding SGS and IF/TA scores to baseline SCr in the model, discrimination by C statistics was 0.83 (95%CI: 0.77-0.90) for prediction of CKD/ESKD . Median renal survival was 3.1 years (95% CI: 2.2-4.1 years) in patients with highest risks score (baseline eGFR<25 ml/min/1.73 m 2 + IF/TA/SGS> 50%), and 8.1 years (95% CI: 7.7-8.6 years).in those with lowest score (baseline eGFR>75 ml/min/1.73 m 2 + IF/TA/SGS <5%). Conclusion: In primary FSGS, higher baseline SCr, increased SGS and IF/TA were the predictors for CKD/ESKD. Baseline proteinuria did not predict the risk of CKD/ESKD. Collapsing variant did not increase the risk of CKD/ESKD after adjustment for IF/TA score. These findings indicated the importance of baseline GFR and the degree of chronicity at biopsy as predictors of kidney outcome .
Application of A Classroom-Based Positive Psychology Education Course on Chinese Medical Students to Increase Their Psychological Well-Being: A Pilot Study
Authors: Zhang Xiao-Qin , Zhang Bao-Shuai , Wang Meng-Die 
Published: January 2020

Abstract
Background Anxiety and depression have been on rise in Chinese medical students due to the heavy academic pressure of medical practice and the deteriorating doctor-patient relationship in China. The psychological well-being of the Chinese medical students has become a critical focus of attention for the medical education community. Increasing evidence showed that positive psychology interventions can be effective in the enhancement of psychological well-being, and may help to prevent depressive symptoms in university students. In the present study, we aimed to explore the potential effect of positive psychology education on improving the mental health of Chinese medical students. Methods An 8-week classroom-based positive psychology intervention workshop, which was set as a selective course embedded in the regular school curriculum, was performed at School of Medicine, South China University of Technology (SCUT), China. Undergraduate medical students of the institute at year-2 or year-3 academic study took part in this training course voluntarily. Self-report data on hope scale, life satisfaction scale, subjective happiness scale, as well as depression and anxiety scale were collected and analyzed at pre-course (n=61) and post-course (n=49) among the participants. The investigation was also validated in an independent cohort of students who enrolled in the course in the following year of the preliminary study. Results The analyses showed that the psychology well-being of the participants were improved after the intervention. Their mean scores on hope scale, life satisfaction scale and subjective happiness scale were significantly improved (P<0.05), while the symptom levels of depression and anxiety were significantly reduced (P<0.01). Similar trend was also observed in the validation cohort. Conclusions These preliminary findings suggest that positive psychology education holds promise for improving the psychological well-being among Chinese medical students. Further investigations in larger and well-controlled sample cohorts may yield more convincible and reliable results.
In vivo model to study the impact of genetic variation on clinical outcome of mastitis in dairy uniparous cows
Authors: Rohmeier Laura , Petzl Wolfram , Koy Mirja , Eickhoff Tordis , Hülsebusch Alina , Jander Sebastian , Macias Laura , Heimes Annika , Engelmann Susanne , Hoedemaker Martina , Seyfert Hans-Martin , Kühn Christa , Schuberth Hans-Joachim , Zerbe Holm , Meyerholz Marie Margarete 
Published: January 2020

Abstract
Background: In dairy herds, mastitis causes detrimental economic losses. Genetic selection offers a sustainable tool to select animals with reduced susceptibility towards postpartum diseases. Studying underlying mechanisms is important to assess the physiological processes that cause differences between selected haplotypes. Therefore, the objective of this study was to establish an in vivo infection model to study the impact of selecting for alternative paternal haplotypes in a particular genomic region on cattle chromosome 18 for mastitis susceptibility under defined conditions in dairy uniparous cows. Results: At the start of pathogen challenge, no significant differences between the favorable (Q) and unfavorable (q) haplotypes were detected. Intramammary infection (IMI) with Staphylococcus aureus 1027 (S. aureus, n = 24, 96 h) or Escherichia coli 1303 (E. coli, n = 12, 24 h) was successfully induced in all uniparous cows. This finding was confirmed by clinical signs of mastitis and repeated recovery of the respective pathogen from milk samples of challenged quarters in each animal. After S. aureus challenge, Q-uniparous cows showed lower somatic cell counts 24 h and 36 h after challenge (P < 0.05), lower bacterial shedding in milk 12 h after challenge (P < 0.01) and a minor decrease in total milk yield 12 h and 24 h after challenge (P < 0.01) compared to q-uniparous cows. Conclusion: An in vivo infection model to study the impact of genetic selection for mastitis susceptibility under defined conditions in dairy uniparous cows was successfully established and revealed significant differences between the two genetically selected haplotype groups. This result might explain their differences in susceptibility towards IMI. These clinical findings form the basis for further in-depth molecular analysis to clarify the underlying genetic mechanisms for mastitis resistance.
Development and preliminary validation of a brief Nurses' Perceived Professional Benefit Questionnaire (NPPBQ)
Authors: Hu Yanli , Hu Jing , Li Liping , Zhao Bin , Liu Xiaohong , Li Fan 
Published: January 2020

Abstract
Background: With the increased empirical interest in the positive significance of improving nurses’ sense of professional benefits, there is a requirement for measures of nurses' perceived professional benefit (NPPB). Our objective was to develop and psychometrically test a brief Nurses' Perceived Professional Benefit Questionnaire (NPPBQ). Methods: After expert consultation and nurse interviews, a primary questionnaire was developed for an exploratory factor analysis (EFA). The seventeen items of the NPPBQ were used for verification of the theorized factor structure and content validity using a confirmatory factor analysis (CFA). The NPPBQ’s concurrent validity was evaluated. Three samples of nurses were collected in Shanghai, Hangzhou and Nanjing between November 2017 and August 2018. Results: The results of the EFA and CFA verified the five dimensions of nurses’ occupational benefit discovery. The results demonstrated that the NPPBQ has adequate internal consistency and is fully consistent with the theorized factor structure. This 5-factor solution explained an adequate percentage of the total variance. The Cronbach’s alpha of each dimension of the NPPBQ was good. The concurrent validity was significantly correlated with all aspects of the Maslach Burnout Inventory (MBI). Conclusion : The results suggest that the NPPBQ is a psychometrically sound measure for evaluating perceived professional benefits among a wide range of nurses. Keywords: Nurses, Psychometrics, Nurses' perceived professional benefit, Instrument development
The Methods and Baseline Characteristics of a VA Randomized Controlled Study Evaluating Supported Employment Provided in Primary Care Patient Aligned Care Teams
Authors: Davis Lori L. , Blansett Catherine M. , Mumba Mercy N. , MacVicar David , Toscano Richard , Pilkinton Patricia , Gay Whitney , Bartolucci Al 
Published: January 2020

Abstract
Background: This article describes the design and baseline sample of a single-site trial comparing Individual Placement and Support (IPS) supported employment delivered within a Veterans Health Administration (VHA) primary care Patient Aligned Care Team (PACT) to treatment-as-usual vocational rehabilitation (TAU-VR) that includes transitional work. Methods: Unemployed U.S. military veterans receiving care in a VHA PACT who were seeking competitive work, otherwise eligible for vocational rehabilitation, and diagnosed with a mental health condition other than a psychotic or bipolar I disorder were prospectively randomized to receive either IPS or TAU-VR. Employment outcomes and measures of quality of life, self-esteem, and community reintegration are being collected for 12 months.Results: The participant sample (n=119) is comprised of 18.5% female, 69.2% African-Americans, and 4.2% Hispanic. Average age is 38.2 (SD ± 8.41) years; 80.7% served in the military since 2001; 78% are receiving or applying for U.S. Department of Veterans Affairs (VA) service-connected disability; 26.9% have not held a competitive job in the past 3 years; and the average length of pre-randomization unemployment is 1.4 (SD ± 2.3) years. Conclusions: Unique design features include evaluating the efficacy of evidenced-based IPS within the primary care setting, having broad diagnostic eligibility, and defining the primary outcome criterion as “steady employment”, i.e. holding a competitive job for ≥26 weeks of the 12-month follow-up period. The findings illustrate the characteristics of a primary care veteran sample in need of employment services.Trial Registration: www.clinicaltrials.gov Identifier: NCT02400736
Incidence of Heart Failure among Diabetic Patients with Ischemic Heart Disease: A Cohort Study
Authors: Abdissa Senbeta Guteta , Deressa Wakgari , Shah Amit J 
Published: January 2020

Abstract
Background: In population studies of heart failure (HF), diabetes mellitus (DM) has been shown to be an independent risk factor. However, the evidence evaluating it as an independent risk factor in incident HF in patients with ischemic heart disease (IHD) is scarce. Our study aimed to assess the incidence of HF in diabetic IHD patients compared to non-diabetic IHD patients in Ethiopia. Methods: A retrospective cohort study was conducted among 306 patients with IHD followed-up at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia. The IHD patients who did not have HF at baseline were followed for 24 months beginning from November 30, 2015. We assessed the incidence of HF in patients with diabetic IHD versus the non-diabetic IHD. Cox proportional hazards models were used to assess the association between diabetic IHD and HF after controlling for important covariates. Hypertension was examined as a possible effect modifier as well. Results: The mean age was 56.8 years, 69% were male, and 31% were diabetic. During the 24 months follow-up period, 196 (64.1%) had incident HF. On multivariate Cox regression, DM was significantly associated with incident HF [Hazard Ratio = 2.04, 95% confidence interval (CI): 1.32-3.14, p = 0.001]. Furthermore, when the patients were stratified by hypertension (HTN) status, DM was associated with worse prognosis, and the strongest association was in those with co-existing DM and HTN [HR = 2.57,95% CI =1.66-3.98, p<0.0001], followed by the presence of DM without HTN [HR 2.27, 95% CI = 1.38-3.71, p=0.001] (compared to those with neither). Conclusion: DM is the strongest predictor of incident HF, compared to other traditional risk factors, in Ethiopian patients with IHD. Those with both DM and HTN are at the highest risk. Key Words: Ischemic heart disease; Heart failure; Incidence; Diabetes Mellitus; Retrospective cohort study
Comparison of methods for detection of in vitro synergy in multidrug-resistant Gram-negative bacteria
Authors: Gaudereto Juliana Januario , Neto Lauro Vieira Perdigão , Leite Gleice Cristina , Sanchez Evelyn , Martins Roberta Cristina Ruedas , Prado Gladys Villas Boas do , Rossi Flavia , Guimarães Thais , Levin Anna Sara , costa silvia figueiredo 
Published: January 2020

Abstract
The use of combined antibiotic therapy has become an option for infections caused by multidrug-resistant (MDR) bacteria. The time-kill (TK) assay is considered the gold standard method for the evaluation of in vitro synergy, but it is a time-consuming and expensive method. The purpose of this study was to evaluate two methods for testing in vitro antimicrobial combinations: the disk diffusion method through disk approximation (DA) and the agar gradient diffusion method by MIC:MIC ratio. TK was included as the gold standard. Sixty-two MDR Gram-negative clinical isolates (28 Pseudomonas aeruginosa , 20 Acinetobacter baumannii , and 14 Serratia marcescens ) were submitted to TK, DA, and MIC:MIC ratio synergy methods. Overall, the agreement between the DA and TK assays ranged from 20 to 93%. As the isolates of A. baumannii showed variable results of synergism according to TK, the calculated agreement was statistically significant in this species against fosfomycin with meropenem, including colistin-resistant isolates. The MIC:MIC ratio method showed agreement range from 35 to 71% with TK assays. The kappa test showed a good agreement for the combination of colistin with amikacin (K = 0.58; P = 0.04) among the colistin-resistant A. baumannii isolates. The DA and MIC:MIC ratio methods are easier to perform and might be a more viable tool for clinical microbiology laboratories.
Leadership Training Programs in Graduate Medical Education: A Systematic Review
Authors: Kumar Bharat , Swee Melissa , Suneja Manish 
Published: January 2020

Abstract
Background: With the increasing recognition that leadership skills can be acquired, there is a heightened focus on incorporating leadership training as a part of graduate medical education. However, there is considerable lack of agreement regarding how to facilitate acquisition of these skills to resident, chief resident, and fellow physicians. Methods: Articles were identified through a search of Ovid MEDLINE, EMBASE, CINAHL, ERIC, PsycNet, Cochrane Systemic Reviews, and Cochrane Central Register of Controlled Trials from 1948 to 2019. Additional sources were identified through contacting authors and scanning references. We included articles that described and evaluated leadership training programs in the United States and Canada. Methodological quality was assessed via the MERSQI (Medical Education Research Study Quality Instrument). Results: 15 studies, which collectively included 639 residents, chief residents, and fellows, met the eligibility criteria. The format, content, and duration of these programs varied considerably. The majority focused on conflict management, interpersonal skills, and stress management. Twelve were prospective case series and three were retrospective. Seven used pre- and post-test surveys, while seven used course evaluations. Only three had follow-up evaluations after six months to one year. MERSQI scores ranged from 6 to 9. Conclusions: Despite interest in incorporating structured leadership training into graduate medical education curricula, there is a lack of methodologically rigorous studies evaluating its effectiveness. High-quality well-designed studies, focusing particularly on the validity of content, internal structure, and relationship to other variables, are required in order to determine if these programs have a lasting effect on the acquisition of leadership skills.
Iodine adequacy in reproductive age and pregnant women living in the Western region of Saudi Arabia
Authors: Azzeh Firas , Refaat Bassem Amr 
Published: January 2020

Abstract

Background:Despite the serious maternal and foetal complications associated with iodine deficiency during pregnancy, surveys related to pregnant women in the Kingdom of Saudi Arabia (KSA) are lacking. This study, therefore, measured urine iodine concentrations (UIC) alongside the potential socioeconomic factors contributing towards iodine inadequacy in reproductive age and pregnant Saudi women from the Western province of KSA.Methods:Spot urine samples were collected from 1222 pregnant and 400 age-matched non-pregnant/non-lactating reproductive age women. The socioeconomic characteristics were obtained through a structured questionnaire. The WHO criteria for iodine sufficiency in non-pregnant (100–199 μg/L) and pregnant (150–249 μg/L) women were applied.Results:The median UIC in the non-pregnant women (101.64 μg/L; IQR: 69.83 – 143.55) was at the lowermost WHO recommended cut-off, whereas the pregnant group were iodine deficient (112.99 μg/L; IQR: 81.01 – 185.57). Moreover, the median UIC was below adequacy across the different trimesters. Multiparity (OR = 3.091; 95%CI: 1.707–5.598) and earning below the minimum wage (2.520; 95%CI: 1.038–6.119) significantly increased the risk of iodine deficiency only in the non-pregnant women. Passive smoking, however, was an independent risk factor for iodine deficiency in the non-pregnant (OR = 1.818; 95%CI: 1.097–3.014) and pregnant (OR = 1.653; 95%CI: 1.043–2.618) groups. The use of non-iodised salt also significantly increased the risk of iodine deficiency in the non-pregnant (OR = 2.052; 95%CI: 1.118–3.766) and pregnant women (OR = 3.813; 95%CI: 1.992–7.297), whereas iodine supplements significantly lowered the risk in both groups (OR = 0.364; 95%CI: 0.172–0.771 and OR = 0.002; 95%CI: 0.001–0.005, respectively). Moreover, BMI correlated independently and significantly with median UIC in the non-pregnant in both study populations.Conclusions:This study is the first to show borderline iodine sufficiency in reproductive age Saudi women from the Western province, whereas mild iodine deficiency was observed in the pregnant population and could represent a serious public health problem. This study also advocates the necessity to establish routine iodine dietary advice services by the health authorities to foster adequate iodine intake in pregnant women to avoid the perilous maternal-foetal health consequences of iodine deficiency.
Biomechanical Changes of Degenerated Adjacent Segment and Intact lumbar Spine after lumbosacral Topping-off surgery: A Three-dimensional Finite Element Analysis
Authors: Cao Liangliang , Liu Yumei , Mei Wei , Xu Jian-guang , Zhan Shi 
Published: January 2020

Abstract
Background : Previous studies have revealed positive effect of Topping-off technique on upper adjacent segment after fusion surgery, while for the cases with fusion surgery on L5-S1 segment, owning maximal range of motion, and preexisting degenerated upper adjacent disc, it is necessary to clarify the superiority of Topping-ff technique and the effect exerted on the lumbar spine. Methods: A young healthy male volunteer was selected for thin-slice CT scanning. Then the image information was imported into the computer to establish the whole lumbar spine model as the health model. The medium degeneration model of intervertebral disc was established by changing the material properties of L4-S1 disc on the basis of the health model, and the fusion model and Topping-off model were respectively established on the basis of the degenerated model. The variation trend of ROM of L2-L5 and the stress changes of L4-L5 intervertebral disc, nucleus pulposus and facet joints were calculated respectively. Results: The L4-L5 ROM of fusion model increased significantly but the ROM of L2-L3 and L3-L4 segments did not change significantly. Compared with the degenerated model, L4-L5 activity of the Topping-off model decreased, and ROM of the L2-L3 and L3-L4 increased to some extent in the flexion and extension positions. the stress on the disc, nucleus pulposus and facet joint of the fusion model L4-L5 increased in four positions of flexion, extension, rotation and bending compared with the degenerated model, while the fiber stress on the Topping-off model decreased significantly in all four positions. Conclusion: Topping-off technology can decrease the stress and ROM of the adjacent upper degenerated segment, and increase the ROM of other upper segments, thereby protecting the degenerated upper adjacent segments and compensating the lumbar spine mobility.