bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraining CP violation in the main decay of the neutral Sigma hyperon
Authors: Perotti E 
Published: November 2020

Abstract
The Σ0 and Λ hyperons are close relatives of the neutron, being related by flavour SU(3) symmetry. This allows to estimate an upper limit for the electric dipole transition moment (EDTM) of the Σ0-Λ transition, based on the experimental knowledge of the upper limit of the neutron electric dipole moment. The three-body decay

Σ
0

→
γ
p

π
−

could show an angular asymmetry due to the interference of parity violating and conserving amplitudes in both the first and second step of the decay chain

Σ
0

→
Λ
γ
→
γ
p

π
−

. This angular asymmetry, which will be measured at e.g. PANDA for both particle and antiparticle decays, is determined in this work from the Σ0-Λ EDTM, where a CP violating QCD theta-vacuum-angle term has been included. It turns out to be below any experimental resolution that one can expect in the foreseeable future. Any experimental significance would therefore point to physics beyond the Standard Model.
Calibration of the electromagnetic calorimeter ECal of the HADES experiment
Authors: Shabanov A , Borisenko D , Chudoba P , Galatyuk T , Guber F , Gumberidze M , Ivashkin A , Kugler A , Lalik R , Morozov S , Pechenov V , Petukhov O , Pietraszko J , Prozorov A , Rathod N , Reshetin A , Rost A , Svoboda O , Salabura P , Tlusty P 
Published: November 2020

Abstract
HADES is a large acceptance spectrometer operating at SIS18, GSI, Germany. It is aimed at exploration of QCD phase diagram at the ion beam energies of 1-2 AGeV in the region of high baryonic densities. The new segmented electromagnetic calorimeter (ECal) was built to extend experimental opportunities of the HADES detector. The electromagnetic calorimeter will allow to study new reaction channels involving the production of neutral mesons and neu-tral resonances in elementary and heavy-ion reactions via detection of their two photon decay. An additional advantage of such a device is the resulting improvement of the electron-to-pion separation at large momenta.
The detector is based on 978 Cherenkov lead glass modules divided into 6 sectors, and it covers forward angles of 12° < θ < 45° and almost full azimuthal angle. Currently four out of six sectors planned are assembled in the experimental area. The first raw beam data obtained with the ECal detector in Ag+Ag reactions at 1.65 AGeV beam are presented.
Preparation of aniline trimer modified graphene oxide new composite coating and study on anticorrosion performance
Authors: Guo Hongfei , Chao Bao , Zhao Zengqi , Nan Ding 
Published: November 2020

Abstract
Graphene oxide (GO) has attracted much attention in anticorrosive coating applications due to its excellent mechanical properties, thermochemical stability and large specific surface area. In this paper, aniline trimer modified GO composites (ATGO) were prepared through modifying GO at different temperatures of 65 °C, 80 °C, 95 °C, and 110 °C, respectively. Aniline trimer modified GO composite coatings (ATGO/EP) were then prepared by adding different quantities of ATGO to epoxy coating, with the mass fractions of 0.05%, 0.1% and 0.3%, respectively. The resulting composite coatings were then sprayed onto Q235 steel plates for characterization and anticorrosion testing. A series of characterization methods such as x-ray diffraction (XRD), Raman spectra, Fourier transform infrared spectroscopy (FT-IR), Atomic force microscopy (AFM) and Transmission electron microscopy (TEM) were used to prove that aniline trimer was successfully grafted on GO. The optimal reaction temperature for ATGO preparation was determined to be 95 °C. Using anticorrosive tests such as Electrochemical impedance spectroscopy (EIS), salt spray test and adhesion test, it was proven that the addition of ATGO can significantly promote anticorrosion performance of epoxy resin (E-44). The optimal addition amount of ATGO to prepare composite coatings was determined to be 0.05 wt%. Its coating resistance after soaking in 3.5% NaCl solution for 10 days was 6.87 × 106 Ω, which was two orders of magnitude higher than the 3.89 × 104 Ω of pure epoxy coating. The importance and originality of this study is that it explores an effective way to improve the anticorrosion performance of epoxy coatings.
Effects of alkaline earth metal elements and their synergistic roles with Ta for Li7La3Zr2O12
Authors: Xue Mingzhe , Lu Wanzheng , Chen Xiaolan , Zhang Cunman 
Published: November 2020

Abstract
Effects of alkaline earth metal elements and their synergistic roles with Ta for the modified Li7La3Zr2O12 (LLZO) are discussed. Li7.1La3Zr1.95M0.05O12 (M = Mg, Ca, Sr, Ba) with the substitution of alkaline earth metal ions for Zr4+ and Li6.5La3Zr1.35Ta0.6M0.05O12 (M = Mg, Ca, Sr, Ba) with the co-substitution of alkaline earth metal ions and Ta5+ for Zr4+ are prepared. The sole substitution of alkaline earth metal elements for Zr in LLZO have little effects on improving ionic conductivity, while the modified LLZO with synergistically co-doping Ta and alkaline earth metal elements can achieve the great enhancement of ionic conductivity. The order of ionic conductivity influenced by Ta5+ and alkaline earth metal ions (Mg2+, Ca2+, Sr2+, Ba2+) co-substitution for Zr4+ demonstrates a strong correlation with ionic radii of Mg2+/Ca2+/Sr2+/Ba2+. Particularly, the enhanced Li6.5La3Zr1.35Ta0.6Mg0.05O12 with the joint substitution of Mg and Ta delivers a highest ionic conductivity of 3.45 × 10−4 S cm−1 at room temperature.
Template method synthesis of highly fluorescent duplex oligonucleotide copper nanomaterials for Fe3+ sensing
Authors: Wuri Han , Ai Jun , Ga Lu 
Published: November 2020

Abstract
Herein, we reported a simple template method for preparation of fluorescent copper nanomaterials, using Duplex oligonucleotide (dsDNA) as the template. The as-prepared copper nanomaterials had good sensing performance, excellent stability and ultrafine size through the characterization of UV–vis absorption spectroscopy, fluorescence spectroscopy, transmission electron microscopy (TEM). Experimental results showed that the fluorescence of copper nanomaterials was linearly quenched by the Fe3+ concentrations in the range of 5–100 μM,The detection limit was 5 μM. And when the temperature is between 25 °C and 70 °C, the fluorescence intensity of copper nanomaterials presents a good linear relationship.
Behavioral Problems at Age 11 Years After Prenatal and Postnatal Exposure to Acetaminophen: Parent-Reported and Self-Reported Outcomes
Authors: Inoue Kosuke , Ritz Beate , Ernst Andreas , Tseng Wan-Ling , Yuan Yuying , Meng Qi , Ramlau-Hansen Cecilia Høst , Strandberg-Larsen Katrine , Arah Onyebuchi A , Obel Carsten , Li Jiong , Olsen Jørn , Liew Zeyan 
Published: November 2020

Abstract
Several studies have reported associations between prenatal acetaminophen exposure and behavioral outcomes in young children. We aimed to evaluate the associations of prenatal and postnatal exposures to acetaminophen with behavioral problems in children at age 11 years, using behavioral measures reported by parents and children. We studied 40,934 mother-child pairs from the Danish National Birth Cohort enrolled during 1996–2002. Parent-reported and child-reported Strengths and Difficulties Questionnaire (SDQ) responses were collected during the 11-year follow-up. We estimated risk ratios for behavioral problems including total difficulties as well as internalizing or externalizing behaviors following prenatal (during pregnancy) or postnatal (within the first 18 months after birth) acetaminophen exposure. Parent-reported and child-reported SDQ scores were moderately correlated; higher for externalizing (r = 0.59) than internalizing (r = 0.49) behaviors. Prenatal acetaminophen exposure was associated with 10%–40% higher risks for total difficulties and internalizing and externalizing problems based on parent- or child-reported SDQ, with the association being stronger for greater cumulative weeks of acetaminophen use. Postnatal exposure was associated with 16%–19% higher risks for parent-reported internalizing behaviors, but the associations were weak or null for child-reported scores except for prosocial behavior. Our study corroborates published associations between prenatal exposures to acetaminophen and behavioral problems and extends the literature to early adolescence.
Novel methods included in SpolLineages tool for fast and precise prediction ofMycobacterium tuberculosiscomplex spoligotype families
Authors: Couvin David , Segretier Wilfried , Stattner Erick , Rastogi Nalin 
Published: November 2020

AbstractBioinformatic tools are currently being developed to better understand the Mycobacterium tuberculosis complex (MTBC). Several approaches already exist for the identification of MTBC lineages using classical genotyping methods such as mycobacterial interspersed repetitive units—variable number of tandem DNA repeats and spoligotyping-based families. In the recently released SITVIT2 proprietary database of the Institut Pasteur de la Guadeloupe, a large number of spoligotype families were assigned by either manual curation/expertise or using an in-house algorithm. In this study, we present two complementary data-driven approaches allowing fast and precise family prediction from spoligotyping patterns. The first one is based on data transformation and the use of decision tree classifiers. In contrast, the second one searches for a set of simple rules using binary masks through a specifically designed evolutionary algorithm. The comparison with the three main approaches in the field highlighted the good performances of our contributions and the significant runtime gain. Finally, we propose the ‘SpolLineages’ software tool (https://github.com/dcouvin/SpolLineages), which implements these approaches for MTBC spoligotype families’ identification.
End of Induction Patient-reported Outcomes Predict Clinical Remission but Not Endoscopic Remission in Crohn’s Disease
Authors: Wong Emily C L , Buffone Elisa , Lee So Jeong , Dulai Parambir S , Marshall John K , Reinisch Walter , Narula Neeraj 
Published: November 2020

Abstract

Background and Aims
It is unclear whether early symptom improvement in Crohn’s disease [CD] provides any prognostic information for patients long-term. This paper aims to investigate the relationship between early patient-reported outcomes [PROs] after completion of induction of infliximab, and their relationship with long-term clinical remission [CR] and endoscopic remission [ER].

Methods
This post-hoc analysis [Clinicaltrials.gov: NCT02096861] used data from 220 CD patients to evaluate the relationship of Weeks 6 and 14 PRO variables and Week 54 clinical remission (Crohn’s Disease Activity Index [CDAI &lt;150), PRO2 remission (mean score abdominal pain [AP] ≤1 and stool frequency [SF] ≤1.5), and endoscopic remission (Simple Endoscopic Score-CD [SES-CD &lt;3). Multivariable logistic regression models adjusted for confounders were used to assess the relationships between post-induction PROs and outcomes of interest.

Results
Patients with moderate or severe AP after induction had reduced odds of achieving 1-year CR and PRO2 remission compared with those with mild AP (adjusted odds ratio [aOR] for CR 0.31, 95% confidence interval [CI] 0.17–0.57, p = 0.0002). Similarly, patients with moderately to severely elevated SF after induction had reduced odds of 1-year CR and PRO2 remission compared with patients with less SF [aOR for CR 0.31, 95% CI 0.16–0.58, p = 0.0003]. No significant differences were found when comparing higher Weeks 6 or 14 PRO scores of AP and/or SF with lower PRO scores in the odds of achieving 1-year ER.

Conclusions
Post-induction PROs of AP and SF strongly predict likelihood of 1-year CR but are not associated with 1-year ER. Clinical symptoms alone should not be relied upon when assessing response to therapies for CD.
Physician Practice Patterns in Holding Inflammatory Bowel Disease Medications due to COVID-19, in the SECURE-IBD Registry
Authors: Agrawal Manasi , Brenner Erica J , Zhang Xian , Colombel Jean-Frederic , Kappelman Michael D , Ungaro Ryan C ,   SECURE-IBD Advisory Committee including, Gearry Richard B , Kalpan Gilaad G , Kissous-Hunt Michele , Lewis James D , Ng Siew C , Rahier Jean-Francois , Reinisch Walter , Ruemmele Frank M , Steinwurz Flavio , Underwood Fox E 
Published: November 2020

Abstract

Background
We aimed to describe physician practice patterns in holding or continuing IBD therapy in the setting of COVID-19 infection, using the Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease [SECURE-IBD] registry.

Methods
IBD medications that were stopped due to COVID-19 were recorded in the SECURE-IBD registry in addition to demographic and clinical data. We conducted descriptive analyses to understand characteristics associated with stopping IBD medications in response to active COVID-19 infection.

Results
Of 1499 patients, IBD medications were stopped in 518 [34.6%] patients. On bivariate and multivariable analyses, a diagnosis of ulcerative colitis or IBD-unspecified was associated with a lower odds of stopping medication compared with Crohn’s disease (adjusted odds ratio [aOR] 0.6, 95% confidence interval [CI] 0.48, 0.75). When evaluating specific medications, 5-aminosalicylic acid was more likely to be continued [p &lt;0.001] whereas anti-tumour necrosis factor therapy and immunomodulator therapy were more likely to be stopped [global p &lt;0.001]. Other demographic and clinical characteristics did not affect prescription patterns.

Conclusions
IBD medications other than immunomodulators were continued in the majority of IBD patients with COVID-19, in the international SECURE-IBD registry. Future studies are needed to understand the impact of stopping or continuing IBD medications on IBD- and COVID-19 related outcomes.
Changes in transvalvular flow patterns after aortic valve repair: comparison of symmetric versus asymmetric aortic valve geometry
Authors: Petersen Johannes , Lenz Alexander , Adam Gerhard , Reichenspurner Hermann , Bannas Peter , Girdauskas Evaldas 
Published: November 2020

Abstract

OBJECTIVES
The aim of this study was to compare the effect of asymmetric versus symmetric bicuspid aortic valve (BAV) repair on transvalvular flow patterns and aortic wall shear stress (WSS).

METHODS
Four-dimensional flow magnetic resonance imaging was prospectively and consecutively performed in patients with congenital aortic valve (AV) disease before and after AV repair. The following MRI-based parameters were assessed: (i) flow eccentricity index, (ii) backward flow across the AV, (iii) grading of vortical and helical flow, and (iv) WSS (N/m2) in the proximal aorta. MRI-derived flow parameters were compared between patients who underwent ‘asymmetric BAV repair’ (n = 13) and ‘symmetric BAV repair’ (n = 7).

RESULTS
A total of 20 patients (39 ± 12 years, 80% male), who underwent BAV repair, were included. In the asymmetric BAV repair group, circumferential WSS reduction was found at the level of the aortic arch (P = 0.015). In the symmetric BAV repair group, postoperative circumferential WSS was significantly reduced compared to baseline at all levels of the proximal aorta (all P &lt; 0.05). Postoperative circumferential WSS was significantly higher in the asymmetric versus symmetric BAV repair group at the level of the sinotubular junction (0.45 ± 0.15 vs 0.30 ± 0.09 N/m2; P = 0.028), ascending aorta (0.59 ± 0.19 vs 0.44 ± 0.08 N/m2; P = 0.021) and aortic arch (0.59 ± 0.25 vs 0.40 ± 0.08 N/m2; P = 0.017). Segmental WSS analysis showed significantly higher postoperative WSS after asymmetric versus symmetric BAV repair, especially in the anterior aortic segment (P = 0.004).

CONCLUSIONS
Symmetric BAV repair results in more physiological flow patterns and significantly reduces WSS, as compared to asymmetric BAV repair. From a haemodynamic point of view, symmetric AV geometry should be attempted in every congenital AV repair.
Long-term performance and risk factors analysis after permanent His-bundle pacing and atrioventricular node ablation in patients with atrial fibrillation and heart failure
Authors: Su Lan , Cai Mengxing , Wu Shengjie , Wang Songjie , Xu Tiancheng , Vijayaraman Pugazhendhi , Huang Weijian 
Published: November 2020

Abstract

Aims
His-bundle pacing (HBP) combined with atrioventricular node (AVN) ablation has been demonstrated to be effective in patients with atrial fibrillation (AF) and heart failure (HF) during medium-term follow-up and there are limited data on the risk analysis of adverse prognosis in this population. In this study, we aimed to evaluate the long-term performance of HBP following AVN ablation in AF and HF.

Methods and results
From August 2012 to December 2017, consecutive AF patients with HF and narrow QRS who underwent AVN ablation and HBP were enrolled. The clinical and echocardiographic data, pacing parameters, all-cause mortality, and heart failure hospitalization (HFH) were tracked. A total of 94 patients were enrolled (age 70.1 ± 10.5 years; male 57.4%). Acute HBP were achieved in 89 (94.7%) patients with successful permanent HBP combined with AVN ablation in 81 (86.2%) patients. Left ventricular ejection fraction (LVEF) improved from 44.9 ± 14.9% at baseline to 57.6 ± 12.5% during a median follow-up of 3.0 (IQR: 2.0–4.4) years (P &lt; 0.001). Heart failure hospitalization or all-cause mortality occurred in 21 (25.9%) patients. The LVEF ≤ 40%, pulmonary artery systolic pressure (PASP) ≥40 mmHg, or serum creatinine (Scr) ≥97 μmol/L at baseline was significantly associated with higher composite endpoint of HFH or death (P &lt; 0.05). The His capture threshold was 1.0 ± 0.7 V/0.5 ms at implant and remained stable during follow-up.

Conclusion
His-bundle pacing combined with AVN ablation was effective in patients with AF and drug-refectory HF. High PASP, high Scr, or low LVEF at baseline was independent predictors of composite endpoint of all-cause mortality or HFH.
Global transcriptome analysis of Rhizobium favelukesii LPU83 in response to acid stress
Authors: Nilsson Juliet F , Castellani Lucas G , Draghi Walter O , Mogro Ezequiel G , Wibberg Daniel , Winkler Anika , Hansen L H , Schlüter Andreas , Pühler Alfred , Kalinowski Jörn , Torres Tejerizo Gonzalo A , Pistorio Mariano 
Published: November 2020

ABSTRACT
Acidic environments naturally occur worldwide and inappropriate agricultural management may also cause acidification of soils. Low soil pH values are an important barrier in the plant–rhizobia interaction. Acidic conditions disturb the establishment of the efficient rhizobia usually used as biofertilizer. This negative effect on the rhizobia–legume symbiosis is mainly due to the low acid tolerance of the bacteria. Here, we describe the identification of relevant factors in the acid tolerance of Rhizobium favelukesii using transcriptome sequencing. A total of 1924 genes were differentially expressed under acidic conditions, with ∼60% underexpressed. Rhizobium favelukesii acid response mainly includes changes in the energy metabolism and protein turnover, as well as a combination of mechanisms that may contribute to this phenotype, including GABA and histidine metabolism, cell envelope modifications and reverse proton efflux. We confirmed the acid-sensitive phenotype of a mutant in the braD gene, which showed higher expression under acid stress. Remarkably, 60% of the coding sequences encoded in the symbiotic plasmid were underexpressed and we evidenced that a strain cured for this plasmid featured an improved performance under acidic conditions. Hence, this work provides relevant information in the characterization of genes associated with tolerance or adaptation to acidic stress of R. favelukesii.
Complementary Protection and Encampment
Authors: Ní Ghráinne Bríd 
Published: November 2020

Abstract
A camp may be described as a temporary space in which individuals receive humanitarian relief and protection until a durable solution can be found to their situation. The camp environment is often riddled with contradictions—the camp can be a place of refuge while at the same time, a place of overcrowding, exclusion and suffering. This article asks to what extent removal of an individual from state A to state B, where he or she will have to live in a camp, is a breach of state A’s human rights law obligations. It argues that even if encampment in state B will expose the individual to terrible conditions, it is unlikely that they will be able to successfully challenge a removal decision before international human rights courts and/or treaty monitoring bodies.
Comparison of clinical outcomes between enucleation and regular pancreatectomy in patients with non-functional pancreatic neuroendocrine tumors: a retrospective multicenter and propensity score-matched study
Authors: Yang Zhen , Gao Hengjun , Lu Jun , Niu Zheyu , Zhu Huaqiang , Zong Yuanyuan , Song Xie , Yang Faji , Zhou Xu 
Published: November 2020

Abstract

Objective
There are limited data from retrospective studies on whether therapeutic outcomes after regular pancreatectomy are superior to those after enucleation in patients with small, peripheral and well-differentiated non-functional pancreatic neuroendocrine tumors. This study aimed to compare the short- and long-term outcomes of regular pancreatectomy and enucleation in patients with non-functional pancreatic neuroendocrine tumors.

Methods
Between January 2007 and July 2020, 227 patients with non-functional pancreatic neuroendocrine tumors who underwent either enucleation (n = 89) or regular pancreatectomy (n = 138) were included. Perioperative complications, disease-free survival, and overall survival probabilities were compared. Propensity score matching was performed to balance the baseline differences between the two groups.

Results
The median follow-up period was 60.76 months in the enucleation group and 43.29 months in the regular pancreatectomy group. In total, 34 paired patients were identified after propensity score matching. The average operative duration in the enucleation group was significantly shorter than that in the regular pancreatectomy group (147.94 ± 42.39 min versus 217.94 ± 74.60 min, P &lt; 0.001), and the estimated blood loss was also significantly lesser (P &lt; 0.001). The matched patients who underwent enucleation displayed a similar overall incidence of postoperative complications (P = 0.765), and a comparable length of hospital stay (11.12 ± 3.90 days versus 9.94 ± 2.62 days, P = 0.084) compared with those who underwent regular pancreatectomy. There were no statistically significant differences between the two groups in disease-free survival and overall survival after propensity score matching.

Conclusion
Enucleation in patients with non-functional pancreatic neuroendocrine tumors was associated with shorter operative time, lesser intraoperative bleeding, similar overall morbidity of postoperative complications, and comparable 5-year disease-free survival and overall survival when compared with regular pancreatectomy.