bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of viral markers, clinical and biochemical profile of viral hepatitis in patients of alcoholic liver disease
Authors: Uma Narendra M. , Parmar Mahendra C. , Shanishwara Parth , Dindod Sonal M. 
Published: December 2019

Background: There is a significant worldwide burden of Alcoholic Liver Disease (ALD). Both alcohol abuse and infection with hepatitis viruses can lead to liver disease. Alcohol and hepatitis viruses have synergistic effects in the development of liver disease. Thus, early detection of virus hepatitis and targeted interventions can improve prognosis in ALD.Methods: This cross-sectional study was conducted among 180 patients coming to Baroda medical college and SSG hospital, Vadodara having alcoholic liver disease were studied and evaluated for markes of viral hepatitis and its clinical and biochemical profile in alcoholic liver disease.Results: our study we had taken 180 patients of alcoholic liver disease out of which male were 92% and female were 8%. Prevalence of viral hepatitis was 27.7% in ALD patients. Out of which hepatitis E was 13% followed by hepatitis A 11%, hepatitis B 4.44% and least was Hepatitis C 0.5%. In clinical profile fever was significantly higher in patients of viral hepatitis with ALD than patients without viral hepatitis. Bilirubin was not significant differ in both groups of patients but SGOT and SGPT had higher values in patients of viral hepatitis with ALD and thus ratio of SGOT/SGPT was also affected due to higher value of SGOT and SGPT.Conclusions: Alcohol consumption and hepatitis virus infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. Patients starting treatment for chronic viral hepatitis infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy specially in chronic hepatitis.
Escitalopram add-on in stable Schizophrenia with subsyndromal depression
Authors: Nischal Anil , Singh Pooja , Agarwal Manu , Nischal Anuradha , Gupta Bandna , Tripathi Adarsh 
Published: December 2019

Background: Significant proportion of the patients of schizophrenia suffer from subsyndromal symptomatic depressive symptoms (SSD) which not only add to the burden of disease but also to the already pre-existing challenges of living with this serious mental illness. Many psychiatrists prescribe antidepressants to patients with schizophrenia who have subsyndromal symptomatic depressive symptoms but data regarding SSD in schizophrenia is meagre. Aim was to study the effect of addition of Escitalopram on psychopathology, cognition and functioning in patients with stable schizophrenia having subsyndromal depressive symptoms and to compare these parameters with patients treated with antipsychotics alone.Methods: The study was a prospective, 8-week randomized double-blind placebo-controlled trial. Seventy four patients who fulfilled the diagnostic criteria of Schizophrenia on the basis of the ICD10-DCR, adjudged to be stable clinically and not requiring any increase in dose of antipsychotic medication over the last eight weeks were recruited into the study. The patients randomly received either Antipsychotics with add-on Escitalopram (10 mg/day) or Antipsychotics with placebo for 8 weeks. The patients were assessed using the HAM-D, CDRS, PANSS, SCoRS, SOFAS and CGI scores at the end of 8 weeks. Patients were also assessed for adverse events at baseline, week 4 and week 8.Results: A total of sixty-six patients who completed the study were analyzed. The HAM-D, CDRS and PANSS score showed significantly better cognition and functioning in the patients of add-on Escitalopram group when compared with the placebo group. There was no significant difference between the two groups in terms of observed side effects.Conclusions: Escitalopram addition to the standard anti-psychotic treatment of schizophrenia, in patients having subsyndromal depressive symptoms, results in better cognition and improved functioning.
Ege Üniversitesi Tıp Fakültesi veri tabanındaki kolorektal kanserli olguların epidemiyolojik ve genel sağ kalım özellikleri
Authors: ÜNAL Nalan Gülşen , COŞGUN Gizem , KORKUT Mustafa , ÖZÜTEMİZ Ahmet Ömer , DOĞANAVŞARGİL Başak , ÇAKAR Burcu , ÖZKÖK Serdar , YALMAN Deniz , SERT Fatma , SEZAK Murat , YOLDAŞ Tayfun , ÇALIŞKAN Cemil , AKGÜN Zekeriya Erhan , OSMANOĞLU Halit , HAYDAROĞLU Ayfer 
Published: December 2019

Amaç: Kolorektal kanser (KRK) epidemiyolojisi ve genel sağ kalım (GSK) özelliklerinin
araştırılmasıdır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Uygulama ve Araştırma Merkezine (EÜKAM)
1992-2017 yıllarında kayıtlı Ege Üniversitesi Tıp Fakültesi kanser verileri retrospektif olarak
taranmıştır. CANREG özel bilgisayar programına kayıtlı veriler, WHO ve SEER sistemlerinde
gruplanarak analizler yapılmıştır. İstatistiksel analizlerde Ki-kare, General Linear Model (GLM),
Kaplan-Meier sağ kalım analizleri kullanılmıştır. Yerel etik kurul onayı alınmıştır.
Bulgular: Toplam 117.139 kanser olgusunun 7.285’i (%6,2) KRK’dir. KRK sıklığı, tüm olgular içinde
yedinci sırada saptanmıştır. Olguların 4.330’u (%59) erkektir. Rektum yerleşimi, %38,4 olguda
saptanmış olup, en sık lokalizasyondur. KRK yaşla artmaktadır; 60 yaş ve üzerinde her iki cinsiyette
de anlamlı artış saptanmıştır (p=0,022); cinsiyetler arası fark anlamlı değildir (p=0,299). KRK’de yıllara
göre doğrusal artış toplamda anlamlıdır (GLM: F=12,349; p
PENGARUH AIR LAUT PADA MASA PERAWATAN TERHADAP INFILTRASI ION KLORIDA PADA BETON DENGAN MENGGUNAKAN SEMEN PORTLAND TIPE V
Authors: Arifatunurrillah Aldilla , Saputra Ashar , Sulistyo Djoko 
Published: December 2019

<p>Struktur beton biasa memiliki tingkat resiko kerusakan yang tinggi pada daerah agresif dan lingkungan yang terbuka. Bangunan-bangunan pelabuhan, dermaga, struktur lepas pantai dan bangunan air laut lainnya tidak lepas dari pengaruh lingkungan agresif yang mengandung garam sulfat, klorida, asam sulfat, dan zat lainnya yang bersifat agresif. Salah satu teknologi aplikatif dan mudah diperoleh dalam pencegahan dampak serangan sulfat adalah penggunaan semen Portland tipe V, oleh karenanya penelitian ini bertujuan untuk mengetahui pengaruh air laut pada masa perawatan dengan variasi umur 28, 60, dan 90 hari terhadap kedalaman infiltrasi ion klorida yang terjadi pada beton dengan penggunaan semen Portland tipe V. Pengujian kedalaman infiltrasi ion klorida dilakukan dengan menyemprotkan larutan perak nitrat (AgNO<sub>3</sub>) 0,1mol/L pada beton yang dibelah sesuai umur perawatan yang ditentukan dengan dimensi beton 15x15x15 cm. Laju infiltrasi ion klorida beton dengan perawatan air laut terjadi pada kedalaman antara 0-1,4 cm hingga umur perawatan 90 hari. Dengan penggunaan semen Portland tipe V laju infiltrasi ion klorida lebih kecil dibandingkan dengan penggunaan semen Portland tipe I pada masing-masing variasi umur perendamannya.</p>
ANALYSIS OF STRUCTURE AND ANTIMICROBIAL ACTIVITY OF CeO2 AND Nd2O3 NANOPARTICLES
Authors: Yuliani Hanif , Mayasari Rina Dewi , Kalembang Eryanti , Deni Yelvia , Santi Defi Rahma , Pangestika Putri Widya , Purwanto Setyo , Sugeng Bambang , Suyanti Suyanti , Setyadji Moch. 
Published: December 2019

Cerium oxide (CeO2) and Neodymium oxide (Nd2O3) nanoparticles using local content have been synthesized by precipitation method. The CeO2 and Nd2O3 nanoparticles were characterized by X-Ray Diffraction (XRD) and Fourier Transform Infrared (FTIR) to analyze the material phase and structure. The XRD spectrum shows that CeO2 and Nd2O3 nanoparticles have face-centered cubic and hexagonal, and cubic, respectively. The anti-microbial activity of CeO2 and Nd2O3 nanoparticles was analyzed by diffusion method using gram-negative bacteria (E. coli, S. aureus, P. aeruginosa), and gram-positive bacteria (S. entericatyphi, L. monocyogenes), and fungus (C. albicans). The result confirms that CeO2 and Nd2O3 nanoparticles have the capability of microbial pathogen inhibition. The CeO2 nanoparticles have the effective activities of inhibition for the microbial of S. aureus and S. entericatyphi, whereas Nd2O3 nanoparticles can inhibit the microbial of P. aeruginosa, S. entericatyphi, and L. monocyogenes.
Developing a Consolidated Research Career Framework for Allied Health Professionals in the UK
Authors: Harris Jennifer Deborah , Grafton Kate , Cooke Jo 
Published: December 2019

Abstract
Background Allied Health Professionals (AHPs) form a significant part of the healthcare workforce, and have a great potential to improve services through research and research-informed practice. However, there is a lack of tradition in undertaking research alongside practice in these professional groups. Barriers include clinical caseload pressures, a lack of training and consequent lack of confidence in practitioners. Practice managers are ill-equipped to monitor and guide staff research development. Uni-professional knowledge & skills frameworks can act as further barriers to research culture across the healthcare system that is moving toward multi-disciplinary research focussing on the patient. A common framework, acceptable to all AHPs might be helpful in planning and developing clinical career pathways. Aim: to develop a consolidated research career framework to help plan and guide research activity throughout AHP clinical-academic careers. The study was conducted in three phases. Methods Phase one identified existing AHP research frameworks (AHPRF) through expert consultations and literature searches. Phase two involved Framework Analysis of the AHPRFs to develop a single consolidated framework. Phase three included a workshop with experts to validate and adapt the framework for practice. Results 19 AHPRFs were identified. A consolidated framework was shaped by analysis of the AHPRFs resulting in a consolidated framework of eight sections, each containing a series of statements. Each section relates to an analytic theme within the thematic analysis, and the statements were based on sub-categories of themes. The final framework was further shaped by the phase three workshop into a set of ‘stem’ statements that can be adapted to reflect different levels of expertise and the inclusion of a set of guiding principles developed through expert consultation. Conclusion The consolidated framework was entitled ‘Shaping Better Practice Through Research: A Practitioner Framework’ by stakeholders, thus emphasising its ambition to embed research activity into practice. It instigates a new perspective within AHP research by offering practitioners and managers a tool that can be applied across public, private and voluntary settings for AHPs in all disciplines. Its ambition is to develop capacity in the AHPs that can undertake research to improve services and the health of service users.
Prevalence of pelvic organ prolapse in women, associated factors and impact on quality of life in rural Pakistan: population-based study.
Authors: Jokhio Abdul Hakeem , rizvi raheela mohsin , Mcarthur Christine 
Published: December 2019

Abstract
Background: Pelvic organ prolapse (POP) is a gynecological condition resulting from pelvic floor dysfunction in women. The objective of this study is to estimate “the prevalence of pelvic organ prolapse” associated factors, duration and impact on women's quality of life in rural Pakistan. Methods: A cross-sectional study was conducted with a three stage random sampling strategy.Three health centers were selected and selected Lady Health Workers from each health center interviewed a random sample of women in their households. The interview used a structured questionnaire to collect symptom data. Female gynaecologists then conducted a clinical examination at the local health centres on women who reported symptoms of prolapse to verify and grade pelvic organ prolapse using Baden-Walker classification system. Results : Among the 5064 women interviewed (95.8% response rate), 521 women had clinically confirmed POP, a prevalence of 10.3% (95% CI 9-11%). Among women with POP 37.8% had grade III or IV prolapse. Women with four or more children had the highest proportion of pelvic organ prolapse (75%) followed by women aged 36-40 years (25%).Among women with POP, 60.8% reported their quality of life as greatly or moderately affected; 44.3% had it for more than 5 years; and 78.7% never consulted a doctor. Conclusions : Pelvic organ prolapse is highly prevalent in rural Pakistan, impacts on women’s everyday lives and remains mainly untreated. Measures should be taken to provide health care services to reduce this burden of disease among women. Keywords Community-based; Pelvic organ prolapse; Prevalence; Quality of life; Pakistan
Association between perceived environmental pollution and health among urban and rural residents-A Chinese national study
Authors: Yang Ting 
Published: December 2019

Abstract
Background: China’s economic boom has led to severe environmental pollution, which has created significant health risks for residents. Although current studies have found urban residents can sense the harmful effects of environmental pollution in China, few studies have talked about their rural counterparts’ attitudes towards the health impacts of environmental pollution. Similarly, little research has talked about the inequality of environmental awareness between urban and rural residents.
Methods: Descriptive and analytical statistics were used for the data analyses based on a national survey, namely, The 3rd Survey on the Status of Chinese Women in 2010, which was jointly conducted by the All China Women's Federation and the China Statistical Bureau in 2010. A total of 24741observations were selected.
Results: Among urban residents, 67.21% reported that their total health was good, which was 1.35% lower than the reported rate of their rural counterparts; 25.88% of urban residents reported that their total health was general, which was nearly 3% higher than the reported rate of their rural counterparts; 6.91% of urban residents reported that their total health was poor, which was 1.63% lower than the reported rate of their rural counterparts. The study also found that the rates of urban residents who perceived air pollution (35.67%), water pollution (17.96%), garbage pollution (25.05%), and noise pollution (32.05%) were higher than those of their rural counterparts. Perceived air pollution, and perceived noise pollution both had a negative effect on urban residents’ good health (B=-0.14, p<0.05; B=-0.23, p<0.001). Perceived garbage pollution had a positive effect on urban residents’ poor health (B=0.33, p<0.01). Perceived water pollution had no significant effect on urban residents’ health. The four types of perceived environmental pollution all had insignificant effects on rural residents’ health.
Conclusions: Rural residents lack awareness of the impacts of environmental pollution on health, which may create risks and vulnerability within the rural environment and the livelihood of these residents. Great attention should be paid to the impacts of environmental pollution on the health of not only urban residents but also rural residents, which will highly improve the support of green development among the public in China.
Integrated Approach in the Control and Management of Skin Neglected Tropical Diseases in three health districts of Côte d’Ivoire
Authors: Koffi Aboa Paul , Yao Théodore Ange Kouakou , BAROGUI YVES Thierry , Diez Gabriel , Djakeaux Simplice , Zahiri Marie Hélène , Sopoh Ghislain Emmanue l , Santos Silvia , Kingsley Asiedu , Johnson Roch Christian , Assé Henri 
Published: December 2019

Abstract
Background
Neglected Tropical Diseases (NTDs) comprise 20 communicable diseases that are prevalent in rural poor and remote communities with less access to the health system. For an effective and efficient control, the WHO recommends to affected countries the implementation of integrated control interventions that take into account the different co-endemic NTDs in the same community. However, implementing these integrated interventions involving several diseases with different etiologies, requiring different control approaches and driven by different vertical programs remains a challenge. We report here the results and lessons learned from a pilot test of this integrated approach based on integrated screening of skin diseases in three co-endemic health districts of Côte d'Ivoire, a West African country endemic for Buruli ulcer, leprosy and yaw three skin NTDs.
Method
This cross-sectional study took place from April 2016 to March 2017 in 3 Districts of Côte d’Ivoire co-endemic for BU, leprosy and yaws. It was carried out in 6 stages: identification of potentially co-endemic communities; stakeholder training; social mobilization; mobile medical consultations; case detection and management; and a review meeting.
Results
In total, 2310 persons screened had skin lesions at the screening stage. Among them, 07 cases were diagnosed as Buruli ulcer. There were 30 leprosy cases and 15 yaws detected. Other types of ulcerations and skin conditions have been identified and represent the majority of cases detected. We learned from this pilot experience that integration can be successfully implemented in co-endemic communities in Côte d’Ivoire. Health workers are motivated and available to implement integrated interventions instead of interventions focused on a single disease. However, it is essential to provide capacity building, a minimum of drugs and consumables for the care of the patients detected, as well as follow up of detected patients including those with other skin conditions.
Conclusions
The results of this study show that the integration of activities can be successfully implemented in co-endemic communities under the condition of a staff capacity building and a minimal care of the detected patients.
A non-randomised trial of video and written educational adjuncts in undergraduate ophthalmology
Authors: Hogg Henry David Jeffry , Pereira Michael , Purdy Julian , Fre Richard J.R. , Lau Gordon B. 
Published: December 2019

Abstract
Background

Provision of relevant pre-learning materials has been shown to increase student engagement and improve outcomes in medical education. This non-randomised study attempts to quantify the educational gains, and relative efficacy of video and written pre-learning materials, in ophthalmology undergraduate teaching.Methods

98 final year medical students were contacted prior to their three-day ophthalmology placements at a British tertiary ophthalmology unit. All participants were sent welcome packs prior to arrival requesting they undertake 90 minutes of work focusing on a list of specified ophthalmic conditions. One cohort (N=33) were sent written materials, another (N=32) was provided with video materials and a third cohort (N=33) were not sent any materials. On arrival participants completed a simple knowledge test, a questionnaire estimating the time they spent preparing for the placement and a self-reported knowledge score. The teaching on placement was the same for all cohorts. At the conclusion of each placement participants completed a challenging knowledge test, a clinical skills test and repeated self-reported knowledge scores.Results

87% of students receiving specified materials claimed to complete pre-placement work compared to 70% of those receiving learning outcomes alone (p=0.05). Students receiving learning materials scored higher in the post-placement tests of knowledge (p<0.001), 74.8% (72.4-77.2%) vs 63.6% (95%CI 59.3-67.9%) and skills (p=0.04), 86.9% (83.9-89.9%) vs 81.3% (77.2-85.4%). Students using video resources outperformed students using written materials in their visual acuity assessment test (p=0.03), 90.4% (86.6-94.2%) vs 83.6% (80.1-87.1%) whilst those receiving written rather than video material performed better in the end of placement knowledge test (p=0.03), 77.7% (74.3-81.1%) vs 72.0% (68.9%-75.1%).Conclusion

This study showed that providing pre-placement learning materials improves undergraduates’ commitment and achievement. Written materials better facilitate knowledge acquisition while video materials preferentially promote skill acquisition. This is a novel demonstration within ophthalmology and can help address the imbalance between the expectations placed on undergraduates and the resources committed to ensuring they are met.
Evaluating the national multisite implementation of dialectical behaviour therapy in a community setting: A mixed methods approach
Authors: Flynn Daniel , Joyce Mary , Gillespie Conall , Kells Mary , Swales Michaela , Spillane Ailbhe , Hurley Justina , Hayes Aoife , Gallagher Edel , Arensman Ella , Weihrauch Mareike 
Published: December 2019

Abstract
Background The implementation of evidence-based interventions for borderline personality disorder in community settings is important given that individuals with this diagnosis are often extensive users of both inpatient and outpatient mental health services. Although work in this area is limited, previous studies have identified facilitators and barriers to successful DBT implementation. This study seeks to expand on previous work by evaluating a coordinated implementation of DBT in community settings at a national level. The Consolidated Framework for Implementation Research (CFIR) [1] provided structural guidance for this national level coordinated implementation.Methods A mixed methods approach was utilised to explore the national multi-site implementation of DBT from the perspective of team leaders and therapists who participated in the coordinated training and subsequent implementation of DBT. Qualitative interviews with DBT team leaders ( n = 8) explored their experiences of implementing DBT in their local service and was analysed using content analysis. Quantitative surveys from DBT therapists ( n = 74) examined their experience of multiple aspects of the implementation process including orienting the system, and preparations and support for implementation. Frequencies of responses were calculated. Written qualitative feedback was analysed using content analysis.Results Five themes were identified from the interview data: team formation, implementation preparation, client selection, service level challenges and team leader role. Participants identified team size and support for the team leader as key points for consideration in DBT implementation. Key challenges encountered were the lack of system support to facilitate phone coaching and a lack of allocated time to focus on DBT. Implementation facilitators included having dedicated team members and support from management.Conclusions The barriers and facilitators identified in this study are broadly similar to those reported in previous research. Barriers and facilitators were identified across several domains of the CFIR and are consistent with a recently published DBT implementation Framework [2]. Future research should pay particular attention to the domain of characteristics of individuals involved in DBT implementation. The results highlight the importance of a mandated service plan for the coordinated implementation of an evidence-based treatment in a public health service.