bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effectiveness of Google, Parsijoo, Rismoon, and Yooz to retrieve Persian documents
Authors: Zeynali Tazehkandi Mahdi , Nowkarizi Mohsen 
Published: March 2020

PurposeThe purpose was to evaluate the effectiveness of Google (as an international search engine) as well as of Parsijoo, Rismoon, and Yooz (as Persian search engines).Design/methodology/approachIn this research, Google search engine as an international search engine, and three local ones, Parsijoo, Rismoon, and Yooz, were selected for evaluation. Likewise, 32 subject headings were selected from the Persian Subject Headings List, and then simulated work tasks were assigned based on them. A total of 192 students from Ferdowsi University of Mashhad were asked to search for the information needed for simulated work tasks in the selected search engines, and then to copy the relevant website URLs in the search form.FindingsThe findings indicated that Google, Parsijoo, Rismoon, and Yooz had a significant difference in the precision, recall, and normalized discounted cumulative gain. There was also a significant difference in the effectiveness (average of precision, recall, and NDCG) of these four search engines in the retrieval of the Persian resources.Practical implicationsUsers using an efficient search engine will attain more relevant documents, and Google search engine was more efficient in retrieving the Persian resources. It is recommended to use Google as it has a more efficient search.Originality/valueIn this research, for the first time, Google has been compared with local Persian search engines considering the new approach (simulated work tasks).
Blockchain and real estate: Dopo di Noi project
Authors: Morena Marzia , Truppi Tommaso , Pavesi Angela Silvia , Cia Genny , Giannelli Jacopo , Tavoni Marco 
Published: March 2020

PurposeThis paper aims at investigating the possibility of effectively implementing the blockchain technology in the real estate environment, specifically applied to the Trust legal instrument in Dopo di Noi (After Us) project, which is intended to guarantee assistance to persons with severe disabilities.Design/methodology/approachThe paper is focused on how to apply the blockchain to the tool of Trust, analyzing the main features and characteristics of this technology.FindingsThe paper proposes two potential solutions for managing the Trust tool in the real estate sector, specifically within the Dopo di Noi project. The first simpler proposal is based on timestamping application. The second one radically changes the classical Trust model and introduces an automatization level in the process.Social implicationsThe paper presents potential applications of the blockchain technology within the framework of Dopo di Noi project, which allows among other features, legal and tax facilitation for the institution of Trusts to benefit persons with severe disabilities.Originality/valueThis paper highlights the potentiality of the combination of the blockchain technology and the real estate environment and applies the blockchain technology to the Dopo di Noi project. Specifically, with the second solution, the paper proposes a platform that gathers, in a single network, various elements of the blockchain technology, such as timestamping, smart property, smart contract, and links them in order to provide services to persons with severe disabilities.
PTPN14, a target gene of miR‐4295, restricts the growth and invasion of osteosarcoma cells through inactivation of YAP1 signalling
Authors: Liang Gaofeng , Duan Chaopeng , He June , Ma Wei , Dai Xing 
Published: March 2020

AbstractNon‐receptor tyrosine phosphatase 14 (PTPN14) has emerged as a novel tumour‐suppressor in a wide range of human cancer types. However, the role of PTPN14 in osteosarcoma remains undetermined. In the present study, we aimed to explore the expression pattern, biological function, and regulation of PTPN14 in osteosarcoma. Low PTPN14 expression levels were detected in osteosarcoma cells, and PTPN14 overexpression markedly decreased the proliferation, colony formation, and invasive potential of osteosarcoma cells. Bioinformatics analysis predicted PTPN14 as a potential target gene of microRNA‐4295 (miR‐4295), and this prediction was validated by a dual‐luciferase reporter assay. PTPN14 expression was negatively modulated by miR‐4295 in osteosarcoma cells. Moreover, PTPN14 expression was inversely correlated with miR‐4295 expression in osteosarcoma tissues. Notably, miR‐4295 inhibition significantly restricted the proliferation and invasion of osteosarcoma cells. PTPN14 overexpression or miR‐4295 inhibition increased the phosphorylation of Yes‐associated protein 1 (YAP1) and impeded YAP1 nuclear translocation, leading to inhibition of YAP1‐mediated transcriptional activity. However, the miR‐4925‐inhibition‐mediated antitumour effect was partially reversed by PTPN14 knockdown. Overall, these results demonstrate that PTPN14 is a miR‐4295 target gene and it exerts a tumour‐suppressive function in osteosarcoma cells via inactivation of YAP1. Our study uncovers a miR‐4295–PTPN14–YAP1 signalling pathway that may play a crucial role in the progression of osteosarcoma.
Risk factors for second‐line dactinomycin failure after methotrexate treatment for low‐risk gestational trophoblastic neoplasia: a retrospective study
Authors: Hoeijmakers YM , Sweep FCGJ , Lok CAR , Ottevanger PB 
Published: March 2020

ObjectiveTo find risk factors for second‐line dactinomycin failure in patients with low‐risk gestational trophoblastic neoplasia (GTN).DesignRetrospective multicentre study.SettingTertiary reference centre.PopulationPatients with low‐risk GTN, treated with dactinomycin after methotrexate (MTX) failure.MethodsRetrospective analysis of 45 patients with low‐risk GTN treated with dactinomycin after MTX failure, registered between 2006 and 2018.Main outcome measuresTreatment outcome and risk factors for second‐line dactinomycin failure.ResultsThirty patients (66.7%) were cured and 15 patients (33.3%) required third‐line therapy. Type of antecedent pregnancy and hCG levels pre‐dactinomycin were risk factors for failure in univariate analysis (odds ratio [OR] 19.30, 95% CI 2.04–182.60, P = 0.01 and OR 2.77, 95% CI 1.18–6.50, P = 0.02, respectively). Level of hCG pre‐dactinomycin remained a significant risk factor in multivariate analysis (OR 2.93, 95% CI 1.02–8.40, P = 0.045). Complete remission (CR) was achieved in 83.3% of patients with pre‐dactinomycin hCG levels <10 ng/ml, in 75% with hCG levels between 10 and 20 ng/ml, in 66.7% with hCG levels between 20 and 30 ng/ml, and in 50% with hCG levels between 30 and 40 ng/ml. No patients with hCG levels >40 ng/ml achieved CR. Patients with dactinomycin failure were treated surgically and/or with multi‐chemotherapy; all except one achieved CR.ConclusionsTreatment with dactinomycin after MTX failure in patients with low‐risk GTN resulted in CR in 66.7%. Chance of curative treatment with dactinomycin is strongly related to the hCG level.Tweetable abstractChance of curative treatment with dactinomycin after MTX failure in GTN patients is strongly related to the level of hCG pre‐dactinomycin.
The influence of obesity on coagulation in healthy term pregnancy as assessed by rotational thromboelastometry
Authors: Lee Julie , Eley Victoria A. , Wyssusek Kerstin H. , Kimble Rebecca M.N. , Way Mandy , Cohen Jeremy , van Zundert André A. 
Published: March 2020

AbstractBackgroundRotational thromboelastometry (ROTEM®) is a point‐of‐care coagulation test which has been used to demonstrate hypercoagulability in pregnant populations and obese populations.AimThe aim of this study was to assess the combined effect of pregnancy and obesity on coagulation using ROTEM® in healthy pregnant women of varying body mass indices (BMIs) presenting for elective caesarean delivery.Materials and MethodsEthics approval was granted for recruitment of women presenting for elective caesarean delivery. Women with any condition affecting coagulation were excluded. The ROTEM® parameters of extrinsically activated thromboelastometric test / fibrin polymerisation test (EXTEM/FIBTEM) amplitude at five minutes (A5), coagulation time (CT), maximum clot firmness (MCF) and clot formation time (CFT) were compared between three different groups: normal weight, overweight and obese women.ResultsOne hundred and eighty‐five women presenting for elective caesarean delivery met inclusion criteria and were divided into three groups; normal weight (BMI < 25 kg/m2, n = 86), overweight (BMI 25–29.9 kg/m2, n = 54) and obese (BMI ≥ 30 kg/m2, n = 45). They had a mean (SD) age of 32.7 ± 5.0 years and the median (interquartile range) BMI of 21.9 kg/m2 (20.5–23.0), 27.0 kg/m2 (26.0–28.5), 36.0 kg/m2 (32.2–41.8) for the normal weight, overweight and obese groups respectively. Forty‐one (22.2%) women were nulliparous. Across the three groups for FIBTEM A5 (P = 0.018), FIBTEM MCF (P = 0.032), FIBTEM CFT (P = 0.047) and EXTEM MCF (P = 0.015) there was evidence of increasing coagulability with increasing BMI. However, following Bonferroni correction, this was no longer significant.ConclusionsThere is no association between BMI and ROTEM® parameters in pregnant women presenting for elective caesarean delivery at term.
The contribution of EU public procurement law to corporate social responsibility
Authors: Ankersmit Laurens 
Published: March 2020

AbstractThis article argues that while EU public procurement law increasingly allows public authorities to take environmental and social considerations into account in public purchasing decisions, it does impose limits on the possibility for authorities to incentivise corporate social responsibility (CSR) policies through public procurement. These specific limits are the result of the EU legislator's choice to endorse the Court of Justice's ordoliberal approach to public procurement law. This approach is in tension with EU CSR policy, and more broadly, the EU's non‐economic goals such as environmental protection, the fight against climate change, human rights and social policy. It reflects a normative preference for the right of undertakings to compete for a tender over the freedom of government authorities to choose a supplier on public interest grounds even if these choices are based exclusively on a legitimate public interest and should be reconsidered.
Appropriateness of array‐CGH in the ADHD clinics: A comparative study
Authors: Baccarin Marco , Picinelli Chiara , Tomaiuolo Pasquale , Castronovo Paola , Costa Anna , Verdecchia Magda , Cannizzaro Chiara , Barbieri Giusi , Sacco Roberto , Persico Antonio M. , Lintas Carla 
Published: March 2020

AbstractAttention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorder with a worldwide prevalence of about 5%. The disorder is characterized by inattentive, hyperactive and impulsive behavior and is often comorbid with other neuropsychiatric conditions. Array comparative genomic hybridization (array‐CGH) testing has been proved to be useful to detect chromosomal aberrations in several neuropsychiatric conditions including autism spectrum disorders (ASD) and intellectual disability (ID). The usefulness of array‐CGH in the ADHD clinics is still debated and no conclusive evidence has been reached to date. We performed array‐CGH in 98 children and adolescents divided in two similarly sized groups according to the clinical diagnosis: (a) one group diagnosed with ADHD as primary diagnosis; (b) the other group in which ADHD was co‐morbid with ASD and/or ID. We detected pathogenetic and likely pathogenetic copy number variants (CNVs) in 12% subjects in which ADHD was co‐morbid with autism and/or intellectual disability and in 8.5% subjects diagnosed with ADHD as primary diagnosis. Detection of CNVs of unknown clinical significance was similar in the two groups being 27% and 32%, respectively. Benign and likely benign CNVs accounted for 61% and 59.5% in the first and second group, respectively. Differences in the diagnostic yield were not statistically significant between the two groups (P > .05). Our data strongly suggest that array‐CGH (a) is a valuable diagnostic tool to detect clinically significant CNVs in individuals with ADHD even in the absence of comorbidity with ASD and/or ID and (b) should be implemented routinely in the ADHD clinics.
Individualized dialysate sodium prescriptions using sodium gradients for high‐risk hemodialysis patients lowered interdialytic weight gain and achieved target weights
Authors: Ramaswamy Kavitha , Brahmbhatt Yasmin , Xia Jin , Song Yiqing , Zhang Jingjing 
Published: March 2020

AbstractIntroductionLarge interdialytic weight gain (IDWG) is associated with increased morbidity and mortality in chronic hemodialysis patients. Over 50% of patients at our inner city tertiary academic center dialysis unit had IDWG and target weights (TW) above goal. We conducted an open‐label nonrandomized study to explore the effects of an individualized dialysate sodium (DNa) prescription using Na gradients in patients at high risk for large IDWG. Thirty‐three patients receiving chronic hemodialysis received individualized DNa prescriptions with a DNa bath of 0 to −2 meq/L below their serum Na level in the intervention group, while patients in the control group were prescribed the standard dialysate Na at 138 mmol/L. Serum Na level, predialysis SBP, symptomatic hypotensive episodes, and %hemodialysis treatments with large IDWG (%TxAIDWG) and above TW(%TxATW) were recorded before and three months after the intervention. We used student t tests to compare continuous variables and Chi‐square tests to compare binary variables between the groups at baseline and after the intervention. Age‐ and sex‐adjusted linear regression models were also constructed to assess the differences in each continuous outcome between the groups. Multivariable logistic regression models were conducted by modeling IDWG decrease and above estimated‐dry‐weight (EDW) decrease as binary dependent variables with adjustment for age, sex, and EDW change.FindingsPatients with individualized DNa concentrations had 3.6 times greater odds of having lower IDWG than those with standard dialysate Na concentration. This significant association remained after adjustment for age, sex, and changes in EDW (OR: 3.63; 95% CI, 1.03–12.9). There was no difference in predialysis BP or symptomatic hypotensive episodes between the two groups.DiscussionIndividualized DNa prescriptions appeared to be well tolerated and may be effective for optimal fluid management in high‐risk hemodialysis patients.
Prolonged Migraine Stuttering Aura: Structural, Functional, and Video Neuroimaging Study of an Atypical Migraine Aura. A Case Report
Authors: Rodríguez‐Castro Emilio , Lagorio Ariela N. , Bejarano‐García Alejandro , Aguiar Pablo , Cortés Julia , Leira Rogelio 
Published: March 2020

BackgroundStuttering is a disorder in the rhythm of speech characterized by an involuntary repetition, prolongation, and cessation of sounds. Neurogenic acquired stuttering is a very rare disorder which could result from different conditions with the involvement of several brain locations.Case ReportA 16‐year‐old male presented to our Hospital with headache associated with blurred vision followed by right‐sided facial and upper limb tingling, clumsiness of right arm, and a complete inability to formulate language which evolved in the next minutes into an intense speech disorder characterized by persistent stuttering. Urgent brain magnetic resonance imaging showed a prominence of venous vasculature in left hemisphere in susceptibility weighted imaging sequence. A fluorodeoxyglucose‐positron emission tomography revealed a bilateral occipital, temporal, and parietal hypometabolism. With the suspicion of migraine aura, analgesic treatment was administered. Symptoms progressively resolved inside 10 hours. Five months later he experienced a similar episode.ConclusionThis case report represents a diagnostic challenge and suggests the inclusion of stuttering within the neurological manifestations of higher cortical dysfunction that can be found as a result of migraine aura.
Cancer‐associated prothrombotic pathways: leucocytosis, but not thrombocytosis, correlates with venous thromboembolism in women with ovarian cancer
Authors: López‐Salazar Javier , Ramírez‐Tirado Laura A. , Gómez‐Contreras Nora , Pacheco‐Bravo Irlanda , Cortés Evelyn , Gallardo Dolores , Arrieta Oscar , Cesarman‐Maus Gabriela 
Published: March 2020

AbstractRisk factors for venous thromboembolism in cancer vary between tumours. Leucocytosis, thrombocytosis, tumour histology and vascular compression may drive thrombosis in ovarian cancer. Thrombosis developed in 13.4% of our patients. Higher median leucocyte, neutrophil and monocyte counts were related to thrombosis. Thrombocytosis >350 × 109/L was frequent (63.8%), but not predictive of thrombosis. Identification of prothrombotic biomarkers may help personalise preventive treatments.
Clinical and economic impact of multipoint left ventricular pacing: A comparative analysis from the Italian registry on multipoint pacing in cardiac resynchronization therapy (IRON‐MPP)
Authors: Forleo Giovanni B. , Santini Luca , Calò Leonardo , Ricciardi Danilo , Curnis Antonio , Pignalberi Carlo , Calzolari Vittorio , Giammaria Massimo , Morani Giovanni , Bertaglia Emanuele , Ribatti Valentina , Biffi Mauro , Potenza Domenico , Piro Agostino , Covino Gregorio , Natale Veronica , Gasperetti Alessio , Notarstefano Pasquale , Lavalle Carlo , Nabutovsky Yelena , Tondo Claudio , Zanon Francesco 
Published: March 2020

AbstractIntroductionEarly evidence suggests that multipoint left ventricular pacing (MPP) may improve response to cardiac resynchronization therapy (CRT). It is unknown whether this benefit is sustained and cost‐effective. We used real‐world data to evaluate long‐term impact of MPP‐ON clinical status, heart failure hospitalizations (HFH) and costs.MethodsThe Italian registry on multipoint left ventricular pacing is a prospective, multicenter registry of patients implanted with MPP‐enabled CRT devices. For this analysis, clinical and echocardiographic data were collected through 24 months and compared between patients with (MPP‐ON) or without (MPP‐OFF) early MPP activation at implant. The total cost of each HFH was estimated with national Italian reimbursement rates.ResultsThe study included 190 MPP‐OFF and 128 MPP‐ON patients with similar baseline characteristics. At 1 and 2 years, the MPP‐ON group had lower rates of HFH vs MPP‐OFF (1‐year hazard ratio [HR]: 0.14, P = .0014; 2‐year HR: 0.38, P = .009). The finding persisted in a subgroup of patients with consistent MPP activation through follow‐up (1‐year HR: 0.19; P = .0061; 2‐year HR: 0.39, P = .022). Total HFH per‐patient costs were lower in the MPP‐ON vs the MPP‐OFF group at 1 year (€101 ± 50 vs €698 ± 195, P < .001) and 2 years (€366 ± 149 vs €801 ± 203, P = .038). More MPP‐ON patients had ≥5% improvement in ejection fraction (76.8% vs 65.4%, P = .025) and clinical composite score (66.7% vs 47.5%, P = .01).ConclusionsIn this multicenter clinical study, early MPP activation was associated with a significant reduction in cumulative HFH and related costs after 1 and 2 years of follow‐up.
Differential response to hepatic differentiation stimuli of amniotic epithelial cells isolated from four regions of the amniotic membrane
Authors: Passaretta Francesca , Bosco Domenico , Centurione Lucia , Centurione Maria Antonietta , Marongiu Fabio , Di Pietro Roberta 
Published: March 2020

AbstractHuman Amniotic Epithelial Cells (hAEC) isolated from term placenta are a promising source for regenerative medicine. However, it has long been debated whether the hAEC population consists of heterogeneous or homogeneous cells. In a previous study, we investigated the characteristics of hAEC isolated from four different regions of the amniotic membrane finding significant heterogeneity. The aim of this study was to evaluate the hepatic differentiation capability of hAEC isolated from these four regions. Human term placentae were collected after caesarean section and hAEC were isolated from four regions of the amniotic membrane (R1‐R4, according to their relative distance from the umbilical cord) and treated in hepatic differentiation conditions for 14 days. hAEC‐derived hepatocyte‐like cells showed marked differences in the expression of hepatic markers: R4 showed higher levels of Albumin and Hepatocyte Nuclear Factor (HNF) 4α whereas R1 expressed higher Cytochrome P450 enzymes, both at the gene and protein level. These preliminary results suggest that hAEC isolated from R1 and R4 of the amniotic membrane are more prone to hepatic differentiation. Therefore, the use of hAEC from a specific region of the amniotic membrane should be taken into consideration as it could have an impact on the outcome of therapeutic applications.
A Survey: Children’s Rights Post Termination of Parental Rights and Pre‐Adoption
Authors: Pelfrey Theresa M. 
Published: March 2020

AbstractThis survey of the statutory provisions and case law of all 50 states and the District of Columbia includes the rights of children to parental support, inheritance, and familial association remaining upon termination of parental rights. A majority of states terminate all the child’s rights at the time parental rights are severed. However, a number of states by explicit statutes or statutory construction have determined that a child’s rights to parental support survives termination of parental rights. This survey examines the prevailing law in each state and suggests statutory reforms to protect the legal status and rights of children.
Accelerated aging by microwave heating and methods to distinguish aging of rice
Authors: Devraj Lavanya , Natarajan Venkatachalapathy , Ramachandran Sinija Vadakkeppulpara , Manicakam Loganathan , Saravanan Shanmugasundaram 
Published: March 2020

AbstractAimTo study the impact of microwave heating (950 and 1,400 W for 72 s) in accelerating the aging process in selected rice varieties, namely IR‐50, Sona masuri, and RNR‐15048 (Rajendranagar variety) stored as brown and polished form.MethodsThe impact was investigated by comparing the efficiencies of two existing chemical methods, namely bromothymol blue indicator (Method‐1) based on the indicator color change with respect to changes in rice pH followed by peroxidase enzyme color reaction (Method‐2) using test tube (spectrophotometer at 470 nm) and single‐grain tests (96‐well plate microplate reader at 386 nm) paralleled with in vitro enzyme assessment for fresh‐aged indices calculation during 6 months of storage.ResultsThe results revealed the maximum R2‐value of 0.993 (brown rice) and 0.963 (polished rice) at 1,400 W for 72 s in RNR‐15048 in single grain test (Method‐1) followed by a maximum R2‐value of 0.976 in brown rice of Sona masuri at 950 W for 72 s and 0.941 in polished rice of RNR‐15048 at 1,400 W for 72 s in single‐grain test (Method‐2).ConclusionAmong the above methods, Method‐1 was found to be more profound in obtaining the consistent results and can be highly recommended for both stake holders and rice processing agencies due to low cost, ease in chemical preparation, and color changes can be easily distinguishable during storage.Practical ApplicationsAging is one of the important and prudent steps in rice grain. Aged rice fetches more price in the market than fresh rice due to improved aroma, texture, and taste after cooking. Accelerated aging requires less storage space and time compared to natural aging. Identification of the aging process in rice grains is a challenging task. Bromothymol blue indicator based on pH change in rice grains due to increase in free fatty acids and peroxidase enzyme color change due to peroxidase enzyme (EC.1.11.1.7) depletion during storage helps to identify the rice aging through fresh‐aged index calculation. Among both the methods, Bromothymol blue indicator is one of the cost‐effective methods for quick identification of rice aging based on indicator color change. This method helps the farmers and other rice processing sectors to distinguish the aged rice from fresh grains as it is cheap, ease in chemical preparation, and affordable.