bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly efficient preparation of Li2O breeder materials with core‐shell structure by oil‐based granulation route
Authors: Chen Ruichong , Qi Jianqi , Shi Qiwu , Shi Yanli , Wang Hailiang , Guo Hao , Zeng Yuanyuan , Yang Mao , Liao Zhijun , Lu Tiecheng 
Published: June 2020

AbstractThis paper gives an oil‐based granulation approach to realize the efficient preparation of Li2O breeder materials, which solve the problems of long preparation cycle, high manufacturing cost and difficult to be homogenization and densification in the past. Li2O precursor spheres with narrow size distribution and uniform spherical shape can be obtained using paraffin oil as binders. The Li2O feed powder with bimodal size distribution will self‐organize to form a core‐shell structured sphere during granulation, in which the core and shell are composed of small particles and large particles, respectively. Notably, the Li2O ceramic spheres sintered at 900°C can achieve a crush load of 40.69 ± 4.01 N and a theoretical density of 79.66% TD, which was not achievable by the methods reported in the previous literature. The strategy proposed in this work not only can be easily extended to other material systems but also opens up a new avenue for the design and preparation of tritium breeder materials with uniform size distribution and satisfactory mechanical properties.
Audit committee quality indices, reporting quality and firm value
Authors: Almaqoushi Wael , Powell Ronan 
Published: June 2020

AbstractWe investigate the relation between audit committee (AC) quality indices, financial reporting, internal control quality and firm value using a US dataset for the period 2002–12. The indices are developed by linking firm value with principal component analysis (PCA) factors based on a broad set of 82 AC variables, some of which influence the quality of the AC, but are not addressed in prior literature. Significant AC factors include ‘overlapping directors’, ‘busyness’ and ‘foreign director’, and we use these factors to develop ‘high’ and ‘low’ AC quality indices. We show that low AC quality firms are more likely to manage earnings, be external auditor dependent with respect to non‐audit tax services, and switch to a lower quality auditor. Low AC quality firms are also more likely to have internal control concerns disclosed by predecessor auditors, including accounting issues, financial restatements, audit opinion concerns and deficiencies that undermine internal control effectiveness. Further, they are more likely to receive an audit report containing additional explanatory notes. Conversely, high AC quality firms are significantly less likely to have these concerns. Our findings highlight the value of using AC quality indices in delivering greater oversight of the financial reporting process.
Involvement of a novel circularRNA, hsa_circ_0000520, attenuates tumorigenesis of cervical cancer cell through competitively binding with miR‐146b‐3p
Authors: Zhang Jinling , Cai Ruyu , Zhang Yifan , Wang Xiaoyu 
Published: June 2020

AbstractThe implication of circular RNAs (circRNAs) in the pathogenesis of human cervical cancer (CC) has been demonstrated by numerous of researches, nevertheless, the whole regulatory network of circRNAs in CC remains unclear. In the present study, two GSE data sets (GSE113696 and GSE102686) were enrolled to analysed different expressed circRNA. We found that hsa_circ_0000520(circ_0000520) was decreased in CC tissues and cell lines. Functional studies indicated circ_0000520 overexpression in vitro repressed CC cell proliferation, invasion and migration, while promoted CC cell apoptosis. Moreover, circ_0000520 overexpression in vivo repressed CC tumour growth. Mechanismly, circ_0000520 and PAX5 were revealed to directly bind to miR‐146b‐3p, and circ_0000520 could indirectly regulate PAX5 by sponging miR‐146b‐3p. In conclusion, circ_0000520 repressed CC progression in vitro and in vivo by sponging miR‐146b‐3p to release PAX5.
Dose‐dependent effect of smoking and smoking cessation on periodontitis‐related tooth loss during 10 ‐ 47 years periodontal maintenance—A retrospective study in compliant cohort
Authors: Ravidà Andrea , Troiano Giuseppe , Qazi Musa , Saleh Muhammad H. A. , Saleh Islam , Borgnakke Wenche S. , Wang Hom‐Lay 
Published: June 2020

AbstractAimWe retrospectively explored effects of smoking on tooth loss due to periodontitis (TLP) in long‐term compliant patients.Materials and MethodsChart data were collected from 258 patients undergoing post‐non‐surgical periodontal treatment (mean 2.24 visits/year) for 10–47.5 (mean 24.2) years. Patients were categorized as: (1) never smokers, (2) former smokers, (3) current light smokers (<10 cigarettes/day) and (4) current heavy smokers (≥10 cigarettes/day).ResultsOf 6,590 teeth present at baseline (mean 25.6 teeth/patient), 264 teeth were lost due to periodontitis, corresponding to 0.03, 0.05, 0.08 and 0.11 TLP annually among never smokers, former smokers, current light smokers and current heavy smokers, respectively. A tooth from a current heavy smoker had 4.4‐fold, 2.7‐fold and 2.6‐fold greater risk of TLP than a tooth from a never smoker, a current light smoker and a former smoker, respectively. Both heavy and light former smokers needed washout periods of approximately 15 years to reach the TLP risk level of never smokers. The TLP risk decreased by 6%/year of smoking cessation.ConclusionsIt took almost 15 years of smoking cessation for the risk of TLP among former smokers to reach the level of never smokers. Hence, the 2018 periodontitis grading system should consider the impact of the “washout” period on former smokers.
Systematic review and sequential network meta‐analysis on the efficacy of periodontal regenerative therapies
Authors: Tsai Shang‐Jie , Ding Yu‐Wei , Shih Ming‐Chieh , Tu Yu‐Kang 
Published: June 2020

AbstractAimsWe aimed to update a previous network meta‐analysis comparing the efficacy of periodontal regenerative therapies on the treatment of infrabony lesions.Materials and MethodsSeven clinical trials were added after literature research for studies published between January 2011 and September 2019. We conducted network meta‐analysis (NMA) to compare the effects of guided tissue regeneration (GTR), enamel matrix derivatives (EMD) and their combination therapies on probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain. Sequential network meta‐analysis (SNMA) was also used to control the type‐I error rate due to multiple testing.ResultsA total of 60 studies were included. For both PPD reduction and CAL gain, the flap operation (FO) was the least effective treatment. Although the differences between periodontal regenerative therapies were small, GTR attained the greatest reduction in PPD, and EMD with bone graft the greatest CAL gain compared to other therapies. SNMA used stricter efficacy criteria, yielding slightly different results from NMA.ConclusionsEMD, GTR, and their combined therapies were more effective than flap operation, although the differences between regenerative therapies remain small in this updated study. SNMA reduces the risk of false‐positive findings, thereby providing more robust evidence on the superiority of treatments.
First records of the seven‐gilled Notorynchus cepedianus and six‐gilled Hexanchus griseus sharks (Chondrichthyes: Hexanchiformes: Hexanchidae) found in the Galápagos Marine Reserve
Authors: Buglass Salome , Nagy Shannon , Ebert David , Sepa Paulina , Turchik Alan , Bell Katherine L. C. , Rivera Fernando , Giddens Jonatha 
Published: June 2020

AbstractThis study reports the first records of cowsharks (Hexanchidae) in the Galápagos Islands, in particular Notorynchus cepedianus and Hexanchus griseus, observed between depths of 210 and 418 m on footage from free‐falling autonomous deep‐ocean cameras. These sightings provide new information on the habitat preferences and range distribution for N. cepedianus and the first records of H. griseus in Ecuadorian waters. The findings support the formulation of regional conservation strategies for these large apex predator species and highlight the limited biological knowledge of Galápagos' deep‐water ecosystems.
Experimental study on collision acceleration and damage characteristics of potato
Authors: Xie Shengshi , Wang Chunguang , Deng Weigang 
Published: June 2020

AbstractTo reveal the mechanism of potato mechanical damage, this article investigated the relationships between the collision characteristics of potato and various impact parameters using potato impact test rig and acceleration acquisition system. It was noted that the potato impact test rig and acceleration acquisition system allowed simultaneously analysis of the three indexes: maximum acceleration, minimum acceleration, and damaged area. In the experiments, the collision damaged area of potato increased with the enlarged tuber mass but decreased with the elevated temperature of potato tuber. In addition, the damaged area was the smallest during potato colliding with 65Mn‐Rubber (10 mm diameter 65Mn steel rod wrapped in 2 mm rubber) compared with other two materials. With the increment of collision initial height, the maximum acceleration and damaged area increased, but the minimum acceleration changed on the basis of opposite trend. Under the experimental factor of collision initial height, the indexes of maximum acceleration and minimum acceleration were strongly correlated with damaged area of potato. That could be used to predict collision effects. Finally, the predicted mathematical model between the average value of maximum acceleration, minimum acceleration and damaged area were established as follows: S = 0.9622amax‐433.25 (R2 = 0.9601), S = −3.9587amin + 58.658 (R2 = 0.8152).Practical applicationCurrently, there are few studies for the collision between fresh potato and rod. Therefore, this study investigated the effect of collision parameters on collision acceleration and damaged area during fresh potato colliding rod. That becomes very important for the design and development of potato processing machinery, especially harvesting machinery. To accurately predict the damage in the phase of harvesting and postharvest processes, the correlation analysis between initial height, tuber mass, tuber temperature, impact material, maximum and minimum acceleration, and damaged area are, respectively, discussed. Meantime, the corresponding mathematical models of significant parameters and damaged area are well established.
The release rate and antimicrobial activity of calcium‐alginate films containing self‐microemulsifying Thymus vulgaris essential oil against Escherichia coli and Staphylococcus aureus
Authors: Almasi Laleh , Radi Mohsen , Amiri Sedigheh 
Published: June 2020

AbstractThe aim of this study was to fabricate antimicrobial calcium‐alginate‐based films containing the self‐microemulsifying thyme essential oil (TEO) formulations using Tween 80 as the surfactant, and acetic (AA) or propionic (PA) acids as the cosurfactants. A Ca‐alginate film containing nano‐emulsified TEO as well as a neat Ca‐alginate film were considered as the controls. The scanning electron microscopy micrographs showed a highly porous texture for SME films, which resulted in an increase in water vapor permeability and water absorption capacity of these films. The SME films released the TEO completely within 155 min and inhibited the growth of S. aureus and E. coli in in vitro antimicrobial tests. The population of S. aureus and E. coli reduced significantly in ground beef covered with SME films. The results of this study showed that self‐microemulsifying TEO films could effectively increase the shelf life of ground beef by controlling its microbial population.
Zero COVID‐19 infection in inflammatory bowel disease patients: Findings from population‐based inflammatory bowel disease registries in Hong Kong and Taiwan
Authors: Mak Joyce Wing Yan , Weng Meng‐Tzu , Wei Shu Chen , Ng Siew Chien 
Published: June 2020

AbstractBackground and AimIt is unsure whether inflammatory bowel disease (IBD) is a risk factor for novel coronavirus infection (COVID‐19).MethodsIBD patients were identified from population‐based databases in Hong Kong and Taiwan from January 21, 2020, until April 15, 2020.ResultsTotal 2954 and 2554 IBD patients were identified in Hong Kong and Taiwan, respectively. None had COVID‐19. Pooled analysis showed that 65.3%, 39.1%, 4.3%, and 12.8% IBD patients in Hong Kong and 75.8 %, 51.4 %, 26.1%, and 52.3 % in Taiwan were on 5‐aminosalicylates, immunomodulators, corticosteroids, and biologics, respectively.ConclusionThere were no reported cases of COVID‐19 infection amongst IBD patients in Hong Kong and Taiwan. IBD patients should continue their usual medications during the COVID‐19 pandemic.
Outcomes of Intensive Care Patients Older Than 90 Years: An 11‐Year National Observational Study
Authors: Haas Lenneke E. M. , Bakhshi‐Raiez Ferishta , van Dijk Diederik , de Lange Dylan W. , de Keizer Nicolette F. 
Published: June 2020

BACKGROUND/OBJECTIVESMany intensive care unit (ICU) physicians are reluctant to admit patients aged 90 years and older, although evidence to support these decisions is scarce. Although the body of evidence on outcomes of patients aged 80 years and older is growing, it does not include patients aged 90 years and older. The aim of this study was to compare the short‐ and long‐term mortality of ICU patients aged 90 years and older in the Netherlands with ICU patients aged 80 to 90 years, that is, octogenarians.DESIGNMulticenter national cohort study over an 11‐year period (2008‐2018), using data of the National Intensive Care Evaluation (NICE) registry and the Dutch insurance claims registry.SETTINGAll 82 ICUs in the Netherlands.PARTICIPANTSAll patients aged 80 years and older at the time of ICU admission.MEASUREMENTSA total of 104,754 patients aged 80 years and older, of whom 9,495 (9%) were 90 years and older, were admitted to Dutch ICUs during the study period.RESULTSICU mortality of the patients aged 90 years and older was lower (13.8% vs 16.1%; P < .001) and hospital mortality was similar (26.1% vs 25.7%; P = .41) compared with octogenarians. After 3 months, mortality was higher for the patients aged 90 years and older (43.1% vs 33.7%; P < .001) and after 1‐year mortality was 55.0% vs 42.7%; P < .001.CONCLUSIONIn the Netherlands, mortality rates of patients aged 90 years and older admitted to the ICU are not as disappointing as often assumed. They have a lower ICU mortality and a similar hospital mortality compared with octogenarians. Nevertheless, their longer term mortality is higher compared with octogenarians. However, almost 3 of 4 patients leave the hospital alive, and almost half of the patients aged 90 years and older are still alive 1 year after their ICU admission. J Am Geriatr Soc 68:1842‐1846, 2020.
The Relationship Between Pregnancy Intentions and Diet or Physical Activity Behaviors in the Preconception and Antenatal Periods: A Systematic Review and Meta‐Analysis
Authors: Nkrumah Isaac , North Madelon , Kothe Emily , Chai Tze Lin , Pirotta Stephanie , Lim Siew , Hill Briony 
Published: June 2020

IntroductionHealthy preconception and antenatal diet and physical activity behaviors may optimize maternal and offspring outcomes. These behaviors are thought to be linked to pregnancy intentions. The aim of this study was to conduct a systematic review and meta‐analysis to determine the association between women's pregnancy intentions and diet or physical activity behaviors in the preconception and antenatal periods.MethodsMEDLINE Complete, PsycINFO, CINAHL Complete, Global Health, Embase, and INFORMIT: Health Subset were searched in September 2018 for studies that evaluated relationships between pregnancy intentions and dietary and physical activity behaviors. Risk of bias was assessed, and random effects meta‐analyses were conducted for dietary (food groups; energy and macronutrients; diet quality; and caffeine, iodine, and folate intake) and physical activity outcomes.ResultsOf 2623 screened records, 19 eligible studies were identified. The overall risk of bias was moderate to high. Twelve studies measured diet and physical activity behaviors during preconception, 5 during pregnancy, and 2 across both periods. Eleven studies measured pregnancy intention retrospectively, and 8 prospectively measured pregnancy intention. The number of studies available for meta‐analyses of individual dietary and physical activity outcomes ranged from 2 to 5. Pregnancy intentions were not associated with preconception fruit, vegetable, or caffeine intake or physical activity. Antenatally, women with intended pregnancies were more likely to report healthier diets, lower caffeine intake, and higher physical activity. Insufficient studies were available to conduct subgroup comparisons for prospective or retrospective assessment.DiscussionPregnancy intentions were not associated with preconception diet or physical activity behaviors. In contrast, antenatally, women with intended pregnancies demonstrated better diet and physical activity behaviors. Given the small number of studies available for meta‐analyses, further research is needed to consolidate our findings. Meanwhile, health professionals can assess women's pregnancy intentions during preconception and pregnancy and encourage a healthy lifestyle.
A Maturity Matrix for Nurse Leaders to Facilitate and Benchmark Progress in Genomic Healthcare Policy, Infrastructure, Education, and Delivery
Authors: Tonkin Emma , Calzone Kathleen A. , Badzek Laurie , Benjamin Caroline , Middleton Anna , Patch Christine , Kirk Maggie 
Published: June 2020

AbstractPurposeNurse leaders driving strategic integration of genomics across nursing need tools and resources to evaluate their environment, guide strategies to address deficits, and benchmark progress. We describe the development and pilot testing of a self‐assessment maturity matrix (MM) that enables users to benchmark the current state of nursing genomic competency and integration for their country or nursing group; guides the development of a strategic course for improvement and implementation; and assesses change over time.DesignMixed‐methods participatory research and self‐assessment.MethodsDuring a 3‐day workshop involving nursing experts in health care and genomics, a genomic integration MM grid was built by consensus using iterative participatory methods. Data were analyzed using descriptive techniques. This work built on an online survey involving the same participants to identify the critical elements needed for “effective nursing which promotes health outcomes globally through genomics.”FindingsExperts from 19 countries across six continents and seven organizations participated in item development. The Assessment of Strategic Integration of Genomics across Nursing (ASIGN) MM incorporates 55 outcome‐focused items serving as subscales for six critical success factors (CSFs): education and workforce; effective nursing practice; infrastructure and resources; collaboration and communication; public/patient involvement; policy and leadership. Users select their current circumstances for each item against a 5‐point ordinal scale (precontemplation to leading). Nurses representing 17 countries undertook matrix pilot testing. Results demonstrate variation across CSFs, with many countries at the earliest stages of implementation.ConclusionsThe MM has the potential to guide the strategic integration of genomics across nursing and enables additional assessments within and between countries to be made.Clinical RelevanceNurse leadership and direction are essential to accelerate integration of genomics across nursing practice and education. The MM helps nurse leaders to benchmark progress and guide strategic planning to build global genomic nursing capacity.
Extrinsic innervation of the pelvic organs in the lesser pelvis of human embryos
Authors: Kruepunga Nutmethee , Hikspoors Jill P. J. M. , Hülsman Cindy J. M. , Mommen Greet M. C. , Köhler S. Eleonore , Lamers Wouter H. 
Published: June 2020

AbstractRealistic models to understand the developmental appearance of the pelvic nervous system in mammals are scarce. We visualized the development of the inferior hypogastric plexus and its preganglionic connections in human embryos at 4–8 weeks post‐fertilization, using Amira 3D reconstruction and Cinema 4D‐remodelling software. We defined the embryonic lesser pelvis as the pelvic area caudal to both umbilical arteries and containing the hindgut. Neural crest cells (NCCs) appeared dorsolateral to the median sacral artery near vertebra S1 at ~5 weeks and had extended to vertebra S5 1 day later. Once para‐arterial, NCCs either formed sympathetic ganglia or continued to migrate ventrally to the pre‐arterial region, where they formed large bilateral inferior hypogastric ganglionic cell clusters (IHGCs). Unlike more cranial pre‐aortic plexuses, both IHGCs did not merge because the 'pelvic pouch', a temporary caudal extension of the peritoneal cavity, interposed. Although NCCs in the sacral area started to migrate later, they reached their pre‐arterial position simultaneously with the NCCs in the thoracolumbar regions. Accordingly, the superior hypogastric nerve, a caudal extension of the lumbar splanchnic nerves along the superior rectal artery, contacted the IHGCs only 1 day later than the lumbar splanchnic nerves contacted the inferior mesenteric ganglion. The superior hypogastric nerve subsequently splits to become the superior hypogastric plexus. The IHGCs had two additional sources of preganglionic innervation, of which the pelvic splanchnic nerves arrived at ~6.5 weeks and the sacral splanchnic nerves only at ~8 weeks. After all preganglionic connections had formed, separate parts of the inferior hypogastric plexus formed at the bladder neck and distal hindgut.
Mandibular osteomyelitis after hyaluronic acid injection
Authors: Wang Hayson Chenyu , Wang Yunting , Long Xiao , Wang Xiaojun 
Published: June 2020

AbstractBackgroundMandibular osteomyelitis after filler injection is extremely rare.AimsWe reported a case of mandibular osteomyelitis after hyaluronic acid injection.PatientsA 33‐year‐old woman received 1 mL hyaluronic acid injection on her chin 1 year ago, after which her chin kept swelling and painful, and gradually ulcerated with pus flowing out. She received antibiotics, debridement procedures, negative pressure wound therapy, and hyperbaric oxygen therapy without symptoms improved. Cone‐beam computed tomography scan showed local bone destruction, sequestrum formation, and tissue calcification on the right mandible body. The patient was diagnosed with mandibular osteomyelitis and received local curettage for the removal of necrotized bone.ResultsLiterature search found no case reports on mandibular osteomyelitis after filler injection so far.ConclusionMinimizing the risk of contamination and infection is strictly required during the filler injection process. Once the patient shows signs of incurable mandibular infection postoperation, clinicians should consider the possibility of osteomyelitis.