bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ependymomas in infancy: underlying genetic alterations, histological features, and clinical outcome
Authors: Jünger Stephanie T. , Andreiuolo Felipe , Mynarek Martin , Dörner Evelyn , zur Mühlen Anja , Rutkowski Stefan , von Bueren Andre O. , Pietsch Torsten 
Published: May 2020

Abstract
Introduction
Young age is an adverse prognostic factor in children with ependymomas. Treatment of these infants is challenging since beneficial therapeutic options are limited. As ependymomas are considered a biologically heterogeneous group, we aimed to characterize infant ependymomas with regard to their histological and genetic features.

Materials and methods
We analyzed 28 ependymomas occurring in children younger than 18 months at diagnosis enrolled into the HIT2000-E protocols with the aim to postpone irradiation until the age of 18 months if possible. All cases underwent neuropathological review, including immunohistochemical characterization. Genome-wide copy number alterations (CNA) were assessed by molecular inversion probe assays, and RELA and YAP1 fusions were detected by RT-PCR and sequencing.

Results
All infant ependymomas were anaplastic (WHO grade III). Twenty-one (75%) cases were located in the posterior fossa. Gross total resection was accomplished in 12 (57%) of these cases. All posterior fossa tumors showed loss of H3-K27me3 characteristic of PFA ependymomas. CNA analysis showed a stable genome in all cases with lack of chromosome 1q gain, an adverse prognostic marker in PFA ependymomas of older children. However, after a median follow-up of 5.4 years, 15 (71%) relapsed, and 9 (43%) died. Seven ependymomas (25%) occurred in the supratentorial region. Gross total resection could be achieved in only two of these cases. Four tumors carried C11orf95-RELA fusions, and two cases had typical YAP1-MAMLD1 fusions (one case was not analyzable). The RELA-fused cases did not display CDKN2A loss as an adverse indicator of prognosis in this disease entity. Although three infants (43%) with supratentorial ependymomas relapsed, all patients survived (median follow-up, 8.0 years).

Conclusion
Infant ependymomas seem to fall into three biological entities, with supratentorial tumors carrying RELA or YAP fusions and PFA posterior fossa ependymomas. The latter showed a poor outcome even though chromosome 1q gain was absent.
The impact of performance filtering on climate feedbacks in a perturbed parameter ensemble
Authors: Rostron John W. , Sexton David M. H. , McSweeney Carol F. , Yamazaki Kuniko , Andrews Timothy , Furtado Kalli , Ringer Mark A. , Tsushima Yoko 
Published: May 2020

AbstractA key contribution to the latest generation of climate projections for the UK (UKCP18) was a perturbed parameter ensemble (PPE) of global coupled models based on HadGEM3-GC3.05. Together with 13 CMIP5 simulations, this PPE provides users with a dataset that samples modelling uncertainty and is ideal for use in impacts studies. Evaluations of global mean surface temperatures for this PPE have shown twenty-first century warming rates consistently at the top end of the CMIP5 range. Here we investigate one potential contributory factor to this lack of spread: that the methodology to select plausible members from a larger, related PPE of atmosphere-only experiments preferentially ruled out those predicted to have more negative climate feedbacks (i.e. lower climate sensitivities). We confirm that this is indeed the case. We show that performance in extratropical long-wave cloud forcing played a key role in this by constraining ice cloud parameters, which in turn constrained the feedback distribution (though causal links are not established). The relatively weak relationship driving this constraint is shown to arise from stronger relationships for the long-wave and short-wave cloud feedback components, which largely cancel out due to changes in tropical high clouds. Moreover, we show that the strength of these constraints is due to a structural bias in extratropical long-wave cloud forcing across the PPE. We discuss how choices made in the methodology to pick the plausible PPE members may result in an overly strong constraint when there is a structural bias and possible improvements to this methodology for the future.
Breast cancer: are long-term and intermittent endocrine therapies equally effective?
Authors: Engel Jutta , Schubert-Fritschle Gabriele , Emeny Rebecca , Hölzel Dieter 
Published: May 2020

Abstract
Purpose
In breast cancer (BC), the duration of endocrine adjuvant therapies (AT) has been extended continuously up to 10 years. We present an alternative explanation for the effect, which could enable shorter treatments.

Method
The relevant literature on chemoprevention and (neo-)adjuvant therapy was reviewed. Data for initiation and growth of primary and contralateral BCs and their metastases (MET) were considered. Also, population-based data from the Munich Cancer Registry for MET-free survival, time trends of MET patterns, and survival achieved by improved ATs are used to estimate all events in the long-term follow-up.

Results
Extended ATs (EAT) that continue after 1, 2, or 5 years reduce mortality only slightly. The effect is delayed, occurring more than 5 years after extension. EATs does not affect the prognosis of 1stBCs, they preventively eradicate contralateral 2ndBCs and thus their future life-threatening METs. Because chemoprevention can eradicate BCs from the smallest clusters to almost detectable BCs, ATs can be temporarily suspended without imposing harm. Results equal to EATs can be achieved by short-term ATs of the 1stBC and by repeated neo-ATs targeted at the indefinitely developing 2ndBCs. Considering this potential in de-escalation, a 70–80% reduction of overtreatment seems possible.

Conclusion
Knowledge of initiation and growth of tumors with known effects of neo-ATs suggest that intermittent endocrine ATs may achieve the same results as EATs but with improved quality of life and survival because of fewer side effects and better compliance. The challenge for developments of repeated ATs becomes: how short is short enough.
Evaluation of a systematic digitized training program on the effectivity of subgingival instrumentation with curettes and sonic scalers in vitro
Authors: Graetz Christian , Fecke Paula , Seidel Miriam , Engel Anne Sophie , Schorr Susanne , Sentker Johanna , Dörfer Christof E. , Sälzer Sonja 
Published: May 2020

Abstract
Objectives
Whereas the key role of subgingival instrumentation in periodontal therapy is well known, the influence of operators’ experience/training with different devices on treatment results is yet uncertain. Therefore, we assessed untrained undergraduate students, working on manikins, as to how effectively they learn to use curettes (GRA) and sonic scalers (AIR); hypothesizing that AIR will result in higher relative cleaning efficacy (RCE) than GRA.

Material and methods
Before baseline evaluation (T0), 30 operators (9 males, 21 females) received a 2-h theoretical lesson for both instruments, followed by a 12-week period with a weekly digitized training program for 45 min. During three sessions (T1–T3), the operators had to instrument six equivalent test teeth with GRA and AIR. At T0–T3, treatment time, proportion of removed simulated biofilm (RCE-b), and hard deposits (RCE-d) were measured.

Results
At T0, RCE-b was in mean(SD) 64.18(25.74) % for GRA, 62.25(26.69) % for AIR; (p = 0.172) and RCE-d 85.48(12.32) %/ 65.71(15.27) % (p < 0.001). At T3, operators reached highest RCE-b in both groups (GRA/AIR 71.54(23.90) %/71.75(23.05)%; p = 0.864); RCE-d GRA/AIR: 84.68(16.84) %/77.85(13.98) %; p < 0.001). Both groups achieved shorter treatment times after training. At T3, using curettes was faster (GRA/AIR 16.67(3.31) min/19.80(4.52) min; p < 0.001).

Conclusions
After systematic digitized training, untrained operators were able to clean 70% of the root surfaces with curettes and sonic scalers.

Clinical relevance
It can be concluded that a systematic digitized and interactive training program in manikin heads is helpful in the training of root surface debridement.
Twisting and constriction of a HeartMate II driveline in the area of a repair site
Authors: Maier Sven , Beyersdorf Friedhelm , Benk Christoph 
Published: May 2020

AbstractThe driveline’s durability is crucial for optimal long-term support with a left-ventricular assist device (LVAD). The incidence of percutaneous driveline fracture after HeartMate II LVAD implantation is low. For the first time, we describe a patient with an already repaired driveline and a massive constriction and twisting of the driveline in the area of the repair site. This dramatic finding necessitates a renewed exchange of the external part of the driveline by the manufacturer. Due to the increasing number of patients with elongated LVAD support, the stability of the driveline and possible repairs including the replacement of the driveline are becoming more and more important. Our case report describes a possible serious late complication after replacement of the driveline, shows possible risks for this development, and describes the necessity of a prophylactic X-ray examination of repaired drivelines to detect such complications as early as possible.
Bi-perspective functions for mixed-integer fractional programs with indicator variables
Authors: Letchford Adam N. , Ni Qiang , Zhong Zhaoyu 
Published: May 2020

AbstractPerspective functions have long been used to convert fractional programs into convex programs. More recently, they have been used to form tight relaxations of mixed-integer nonlinear programs with so-called indicator variables. Motivated by a practical application (maximising energy efficiency in an OFDMA system), we consider problems that have a fractional objective and indicator variables simultaneously. To obtain a tight relaxation of such problems, one must consider what we call a “bi-perspective” (Bi-P) function. An analysis of Bi-P functions leads to the derivation of a new kind of cutting planes, which we call “Bi-P-cuts”. Computational results indicate that Bi-P-cuts typically close a substantial proportion of the integrality gap.
Artifacts in fluoroscopy and changes in radiation dose caused by heating blankets and insulating covers during simulated endovascular treatment
Authors: Podsiadło Paweł , Liszka Grzegorz , Popiela Tadeusz , Sanak Tomasz , Kosiński Sylweriusz , Darocha Tomasz 
Published: May 2020

Abstract
Purpose
We aimed to assess whether insulating covers and warming systems cause artifacts in fluoroscopy, and whether they alter the radiation dose.

Methods
Eight insulating and warming systems were wrapped around the phantom in order to obtain images in fluoroscopy, and to measure the absorbed and scattered radiation dose. A dosimeter, endovascular catheters, and stents were placed into a phantom. The other dosimeter was placed outside of a C-arm table, at the operator’s and anesthesiologist’s locations.

Results
Most of the insulating covers did not cause artifacts in the fluoroscopy and led to a significant decrease in both the absorbed and scattered radiation dose. The highest decrease in the absorbed dose was observed with metalized foil (− 2.09%; p = 0.001) and in the scattered dose with Helios cover (− 55%; p < 0.001). Only one heating system (Ready Heat combined with Hypothermia Prevention and Management Kit cover) caused significant artifacts and increased radiation up to 99% (p < 0.001).

Conclusion
Thermal insulation may be maintained during X-ray-guided emergency endovascular procedures in trauma victims. Self-heating blankets should be replaced with another warming system.
On the use of the terminal-value approach in risk-value models
Authors: Dorfleitner Gregor 
Published: May 2020

AbstractWe extend risk-value models for valuing streams of risky cash flows by establishing the well-known concept of terminal value in this context. For a constant growth assumption we are able to derive upper and lower bounds for the terminal value in the case of a translation-invariant and in the case of a position-invariant risk measure. For both cases we also obtain an exact formula under a special growth assumption for the future cash flows. Furthermore, we provide results on the applicability of the general findings for the case that the log-return of the risky investment follows a Brownian motion.
The Prospects for a Monist Theory of Non-causal Explanation in Science and Mathematics
Authors: Reutlinger Alexander , Colyvan Mark , Krzyżanowska Karolina 
Published: May 2020

AbstractWe explore the prospects of a monist account of explanation for both non-causal explanations in science and pure mathematics. Our starting point is the counterfactual theory of explanation (CTE) for explanations in science, as advocated in the recent literature on explanation. We argue that, despite the obvious differences between mathematical and scientific explanation, the CTE can be extended to cover both non-causal explanations in science and mathematical explanations. In particular, a successful application of the CTE to mathematical explanations requires us to rely on counterpossibles. We conclude that the CTE is a promising candidate for a monist account of explanation in both science and mathematics.
Scheduling and loading problem for multiple, identical dry kilns
Authors: Huka Maria Anna , Rindler Christian , Gronalt Manfred 
Published: May 2020

AbstractThe drying of sawn lumber is one of the major processing steps in sawmills with high production volumes. Existing publications on kiln drying analyse and improve technological conditions, while this paper focuses on the scheduling and loading planning with time availability of the individual dried packages. To improve dry kiln scheduling for multiple and identical kilns in large softwood processing sawmills, heuristic approaches are developed that generate kiln allocation plans according to existing production specifications. The aim is to minimise total tardiness for the drying of all sawn lumber packages while considering technological and capacity restrictions. These heuristics calculate the position, time and kiln for each package, thus solving scheduling and loading problems caused by capacity and stacking limitations. Several heuristic approaches are illustrated and tested with actual production data. In addition, the difference between static and dynamic scheduling for group and batch generation is analysed. Further improvements are possible through: drying of different lumber assortments in one batch, outsourcing the drying of special assortments or investing in supplementary kilns for drying smaller volumes within more flexible time slots.
Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system—from molecular mechanisms to therapeutic applications
Authors: Sobczuk Paweł , Czerwińska Magdalena , Kleibert Marcin , Cudnoch-Jędrzejewska Agnieszka 
Published: May 2020

AbstractFew millions of new cancer cases are diagnosed worldwide every year. Due to significant progress in understanding cancer biology and developing new therapies, the mortality rates are decreasing with many of patients that can be completely cured. However, vast majority of them require chemotherapy which comes with high medical costs in terms of adverse events, of which cardiotoxicity is one of the most serious and challenging. Anthracyclines (doxorubicin, epirubicin) are a class of cytotoxic agents used in treatment of breast cancer, sarcomas, or hematological malignancies that are associated with high risk of cardiotoxicity that is observed in even up to 30% of patients and can be diagnosed years after the therapy. The mechanism, in which anthracyclines cause cardiotoxicity are not well known, but it is proposed that dysregulation of renin-angiotensin-aldosterone system (RAAS), one of main humoral regulators of cardiovascular system, may play a significant role. There is increasing evidence that drugs targeting this system can be effective in the prevention and treatment of anthracycline-induced cardiotoxicity what has recently found reflection in the recommendation of some scientific societies. In this review, we comprehensively describe possible mechanisms how anthracyclines affect RAAS and lead to cardiotoxicity. Moreover, we critically review available preclinical and clinical data on use of RAAS inhibitors in the primary and secondary prevention and treatment of cardiac adverse events associated with anthracycline-based chemotherapy.
Clinical inertia in the treatment of heart failure: a major issue to tackle
Authors: Verhestraeten Caroline , Heggermont Ward A. , Maris Michael 
Published: May 2020

AbstractDespite an enormous improvement in heart failure management during the last decades, the hospitalization and mortality rate of heart failure patients still remain very high. Clinical inertia, defined as the lack of treatment intensification in a patient not at evidence-based goals for care, is an important underlying cause. Clinical inertia is extensively described in hypertension and type 2 diabetes mellitus, but increasingly recognized in heart failure as well. Given the well-established guidelines for the management of heart failure, these are still not being reflected in clinical practice. While the absolute majority of patients were treated by guideline-directed heart failure drugs, only a small percentage of these patients reached the correct guideline-recommended target dose of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, mineralocorticoid receptor antagonists, and angiotensin receptor-neprilysin inhibitors. This considerable under-treatment leads to a large number of avoidable hospitalizations and deaths. This review discusses clinical inertia in heart failure and explains its major contributing factors (i.e., physician, patient, and system) and touches upon some recommendations to prevent clinical inertia and ameliorate heart failure treatment.
Pure Functions in C: A Small Keyword for Automatic Parallelization
Authors: Süß Tim , Nagel Lars , Vef Marc-André , Brinkmann André , Feld Dustin , Soddemann Thomas 
Published: May 2020

AbstractThe need for parallel task execution has been steadily growing in recent years since manufacturers mainly improve processor performance by increasing the number of installed cores instead of scaling the processor’s frequency. To make use of this potential, an essential technique to increase the parallelism of a program is to parallelize loops. Severalautomatic loop nest parallelizershave been developed in the past such as PluTo. The main restriction of these tools is that the loops must be statically analyzable which, among other things, disallows function calls within the loops. In this article, we present a seemingly simple extension to the C programming language which marks functions without side-effects. These functions can then basically be ignored when the automatic parallelizer checks the parallelizability of loops. We integrated the approach into the GCC compiler toolchain and evaluated it by running several real-world applications. Our experiments show that the C extension helps to identify additional parallelization opportunities and, thus, to significantly increase the performance of applications.
On the Assessed Strength of Agents’ Bias
Authors: Landes Jürgen , Osimani Barbara 
Published: May 2020

AbstractRecent work in social epistemology has shown that, in certain situations, less communication leads to better outcomes for epistemic groups. In this paper, we show that, ceteris paribus, a Bayesian agent may believe less strongly that a single agent is biased than that an entire group of independent agents is biased. We explain this initially surprising result and show that it is in fact a consequence one may conceive on the basis of commonsense reasoning.
Scenario-based seismic hazard analysis using spectral element method in northeastern Pakistan
Authors: Khan Saad , van der Meijde Mark , van der Werff Harald , Shafique Muhammad 
Published: May 2020

AbstractSeismic hazard analysis is carried out in this study by estimating ground motion for hypothetical earthquakes in the area of Muzaffarabad, Pakistan, with the MT solution of the 2005 Kashmir earthquake. The earth’s topography influences seismic waves by scattering and reflecting it, thereby causing spatial variation in seismic response. Using the moment tensor solution of the 2005 Kashmir earthquake, we perform 25 spectral element method (SEM)-based 3D simulations along major faults in the study area. The SEM model incorporates the topography and homogeneous half-space characteristics. Our results show that, beside topography, the relative location of the source with respect to slopes also has an influence on the observed variation in ground shaking amplitudes. By integrating the mean and standard deviation of estimated ground shaking from 25 simulations, we present a seismic hazard map for the study area. The map summarizes the topographic and potential source location effect on seismic-induced ground shaking in the study area. It provides a classification from hazardous to safe in relative terms and can be used as a guide in earthquake preparedness.
Association of health literacy and cognition levels with severity of adverse drug reactions in cancer patients: a South Asian experience
Authors: Gupta Vishal , Shivaprakash Gangachannaiah , Bhattacherjee Dipanjan , Udupa Karthik , Poojar Basavaraj , Sori Ravi , Mishra Shubhangi 
Published: May 2020

AbstractBackground The occurrence of adverse drug reactions with chemotherapy among cancer patients is a well-documented phenomenon. However, the understanding of contributoring factors and their influence on the severity of adverse drug reactions is incomplete without the psychosocial factors affecting them. Objective The present study was done to understand if factors like Health literacy and cognition levels have an association with the severity of adverse drug reactions of cancer chemotherapy. Setting This study was done in the Department of Medical Oncology in a tertiary care hospital in India. Method Two hundred and twenty-four patients meeting the study inclusion and exclusion criteria took part in the study. Details of adverse drug reactions were collected as per the central drugs standard control organization format and severity of adverse drug reactions assessed with National Cancer Institute common terminology criteria of adverse events, version 5.0. Health Literacy and Cognition Levels of patients were assessed using standardized questionnaires, i.e., Short test of functional health literacy in adults and short portable mental status questionnaire, respectively. Data were anonymized and analyzed using Statistical Package for Social Sciences version 16.0 software. Pearson’s Chi square test (p value ≤ 0.05 was considered statistically significant) was used to study the associations. Main outcome measure The associations of Health Literacy and Cognition Levels with the severity of adverse drug reactions. Result We found that both Health Literacy and Cognition Levels had a statistically significant association with Grade 3 and above adverse drug reactions in cancer patients receiving chemotherapy. Conclusion An initial assessment of Health Literacy and Cognition Levels in cancer patients by cancer care providers can help identify patients at high risk of developing severe adverse drug reactions. Interventional measures for improving Health Literacy by healthcare providers can help reduce the overall burden of disease on the patient due to adverse drug reactions.