bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of the top of the saturated zone from airborne electromagnetic data
Authors: Dewar Noah , Knight Rosemary 
Published: June 2020

In an airborne electromagnetic (AEM) data set acquired in unsaturated and saturated zones, the depth of the top of the saturated zone (TSZ) at the time of data acquisition should be accounted for in the resistivity-to-lithology transform. We have developed and tested a methodology for estimating the TSZ from AEM data, using data collected in three survey areas in the Central Valley of California and water-table elevation (WTE) measurements from nearby wells. The methodology is based on the difference in the distribution of resistivity values above and below the TSZ, using the WTE measurements to optimize two components of the general workflow. From the AEM data acquired in Tulare County, in the southern portion of the Central Valley, where the WTE measurements were acquired two to four weeks before the AEM data acquisition, we have found estimates of the TSZ with a root-mean-square (rms) error of 10.6 m when compared to the WTE measurements. From the two survey areas in Butte and Glenn counties, in the northern portion of the Central Valley, where WTE measurements were available at the time of, and closer to the locations of, AEM data acquisition, we have found estimates of the TSZ with an rms error ranging from 3.8 to 5.3 m, depending on the form of inversion. The level of error found in the three survey areas is comparable to the thickness of the layers in the resistivity models at the depths of the TSZ. Because the intended use of these estimates is to locate the TSZ for use in developing and applying the resistivity-to-lithology transform, the level of error associated with this new methodology is acceptable.
Is Advance Care Planning Associated With Decreased Hope in Advanced Cancer?
Authors: Cohen Michael G. , Althouse Andrew D. , Arnold Robert M. , Bulls Hailey W. , White Douglas , Chu Edward , Rosenzweig Margaret , Smith Kenneth , Schenker Yael 
Published: June 2020

PURPOSE: Providers have cited fear of taking away hope from patients as one of the principal reasons for deferring advance care planning (ACP). However, research is lacking on the relationship between ACP and hope. We sought to investigate the potential association between ACP and hope in advanced cancer. METHODS: This is a cross-sectional analysis of baseline data from a primary palliative care intervention trial. All patients had advanced solid cancers. Three domains of ACP were measured using validated questions to assess discussion with oncologists about end-of-life (EOL) planning, selection of a surrogate decision maker, and completion of an advance directive. Hope was measured using the Hearth Hope Index (HHI). Multivariable regression was performed, adjusting for variables associated with hope or ACP. RESULTS: A total of 672 patients were included in this analysis. The mean age was 69.3 ± 10.2 years; 54% were female, and 94% were White. Twenty percent of patients (132 of 661) reported having a discussion about EOL planning, 51% (342 of 668) reported completing an advance directive, and 85% (565 of 666) had chosen a surrogate. There was no difference in hope between patients who had and had not had an EOL discussion (adjusted mean difference in HHI, 0.55; P = .181 for adjusted regression), chosen a surrogate (adjusted HHI difference, 0.31; P = .512), or completed an advance directive (adjusted HHI difference, 0.11; P = .752). CONCLUSION: In this study, hope was equivalent among patients who had or had not completed 3 important domains of ACP. These findings do not support concerns that ACP is associated with decreased hope for patients with advanced cancer.
A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor
Authors: Ma Huilin , Wang Hanwen , Sove Richard J. , Jafarnejad Mohammad , Tsai Chia-Hung , Wang Jun , Giragossian Craig , Popel Aleksander S. 
Published: June 2020

AbstractCancer immunotherapy has recently drawn remarkable attention as promising results in the clinic have shown its ability to improve the overall survival, and T cells are considered to be one of the primary effectors for cancer immunotherapy. Enhanced and restored T cell tumoricidal activity has shown great potential for killing cancer cells. Bispecific T cell engagers (TCEs) are a growing class of molecules that are designed to bind two different antigens on the surface of T cells and cancer cells to bring them in close proximity and selectively activate effector T cells to kill target cancer cells. New T cell engagers are being investigated for the treatment of solid tumors. The activity of newly developed T cell engagers showed a strong correlation with tumor target antigen expression. However, the correlation between tumor-associated antigen expression and overall response of cancer patients is poorly understood. In this study, we used a well-calibrated quantitative systems pharmacology (QSP) model extended to bispecific T cell engagers to explore their efficacy and identify potential biomarkers. In principle, patient-specific response can be predicted through this model according to each patient’s individual characteristics. This extended QSP model has been calibrated with available experimental data and provides predictions of patients’ response to TCE treatment.
Flavor perception of wine is unchanged during commercial flight: a comparative field study
Authors: Gram-Hanssen Anders , Bøge Paulsen Cecilie , Rosenberg Jacob 
Published: June 2020

Background: It is generally accepted that the human perception of flavor and odor is altered in low-pressure environments such as airplane cabins. This has been demonstrated in several simulation studies, but never in a field study conducted in an authentic environment, and never using wine as the object of study. Methods: We performed a comparative field study composed of two wine tastings. The first tasting was conducted on board an aircraft flying at standard cruising altitude and the second tasting was conducted at ground level. Subjective taste experience and current mood were evaluated through a validated questionnaire. The study was reported according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline. Results: The study included 22 participants, none of whom had any special training in wine tasting. No statistically significant difference in experienced flavor intensity was found between the high and low altitude tests, with median aromatic intensities of 5 (interquartile range 3.5-6.0) and 5 (interquartile range 4.0-6.5) respectively, measured on a 9-point hedonic scale. Additionally, there was no detectable difference in several other taste parameters. Conclusions: These findings suggest that even though experimental studies have demonstrated that senses of taste and smell may be suppressed on commercial flights, the subjective wine tasting experience of non-professionals in real life testing may not be affected.
Online Demand Fulfillment Under Limited Flexibility
Authors: Xu Zhen , Zhang Hailun , Zhang Jiheng , Zhang Rachel Q. 
Published: June 2020

We study online demand fulfillment in a class of networks with limited flexibility and arbitrary numbers of resources and request types. We show analytically that such a network is both necessary and sufficient to guarantee a performance gap independent of the market size compared with networks with full flexibility, extending the previous literature from the long chains to more general sparse networks. Inspired by the performance bound, we develop simple inventory allocation rules and guidelines for designing such network structures. Numerical experiments including one using some real data from Amazon China are conducted to confirm our findings as well as some of the flexibility principles conjectured in the literature. This paper was accepted by Chung Piaw Teo, optimization.
Prevention of pressure ulcers among individuals cared for in the prone position: lessons for the COVID-19 emergency
Authors: Moore Zena , Patton Declan , Avsar Pinar , McEvoy Natalie L , Curley Gerard , Budri Aglecia , Nugent Linda , Walsh Simone , O'Connor Tom 
Published: June 2020

Objective: Pressure ulcers (PUs) involve the destruction of skin and underlying tissue due to prolonged pressure and shear forces. These ulcers are painful and significantly reduce a person's quality of life. PUs are also expensive to manage and impact negatively on the achievement of cost-effective, efficient care delivery. Method: Prone positioning is a postural therapy that aims to enhance respiratory function through increasing oxygenation levels. In contemporary clinical practice, ventilation in the prone position is indicated for patients with severe acute respiratory distress syndrome. However, despite its advantages in terms of respiratory function, several studies have examined complications of prone position ventilation and have identified PUs (facial PUs as well as PUs on other weight-bearing areas of the body) as a frequent complication in patients who are already in a precarious medical situation. International data suggest that up to 57% of patients nursed in the prone position develop a PU. The aim of this clinical review is to identify and review evidence-based recommendations developed to facilitate the selection and application of preventive interventions aimed at reducing PU development in patients ventilated in the prone position. Given the current COVID-19 crisis, this review is timely as intensive care unit (ICU) patients with COVID-19 require ventilation in the prone position at a level that is disproportionate to the general intensive care population. Up to 28% of patients admitted to the ICU with confirmed infection due to severe COVID-19 are cared for in the prone position. The scope of this review is limited to adult individuals only. Results: The skin assessment should be undertaken before proning and following positioning the patient back into the supine position. Although it is essential to keep the skin clean and moisturised, using pH-balanced cleansers, there is inconsistency in terms of the evidence to support the type of moisturiser. Use of positioning devices in addition to repositioning is recommended to offload pressure points on the face and body. Further, using dressings such as hydrocolloids, transparent film and silicone may be of benefit in decreasing facial skin breakdown. Conclusion: Given the importance of PU prevention in this cohort of patients, adopting a focused prevention strategy, including skin assessment and care, offloading and pressure redistribution, and dressings for prevention may contribute to a reduction in the incidence and prevalence of these largely preventable wounds.
Traditional and advanced therapeutic modalities for wounds in the paediatric population: an evidence-based review
Authors: McNamara Stephanie A , Hirt Penelope A , Weigelt Maximillian A , Nanda Sonali , de Bedout Valeria , Kirsner Robert S , Schachner Lawrence A 
Published: June 2020

Objective: Children can have non-healing wounds due to a wide range of pathologies, including epidermolysis bullosa (EB), pilonidal disease and Stevens-Johnson syndrome, with some causes being iatrogenic, including extravasation injuries and medical device-related hospital-acquired pressure ulcers. Furthermore, paediatric wounds are vastly different from adult wounds and therefore require a different treatment approach. While there are numerous types of dressings, topical remedies, and matrices with high-tier evidence to support their use in adults, evidence is scarce in the neonatal and paediatric age groups. The purpose of this review is to discuss the basic principles in paediatric wound management, as well as to present new treatment findings published in the literature to date. The benefits and risks of using different types of debridement are discussed in this review. Various topical formulations are also described, including the need to use antibiotics judiciously. Method: Databases were searched for relevant sources including Pubmed, Embase, Web of Science and DynaMed. Search terms used included ‘wound care’, ‘wound management’, ‘paediatrics’, ‘children’, ‘skin substitutes’, and ‘grafts’. Additionally, each treatment and disease entity was searched for relevant sources, including, for example: ‘Apligraf’, ‘dermagraft’, ‘Manuka honey’, ‘antibiotic’, ‘timolol’, and ‘negative pressure wound therapy’ (NPWT). Results: Amniotic membrane living skin equivalent is a cellular matrix that has been reportedly successful in treating paediatrics wounds and is currently under investigation in randomised clinical trials. Helicoll is an acellular matrix, which shows promise in children with recessive dystrophic EB. NPWT may be used as a tool to accelerate wound closure in children; however, caution must be taken due to limited evidence to support its safety and efficacy in the paediatric patient population. Integra has been reported as a useful adjunctive treatment to NPWT as both may act synergistically. Hospitalised children and neonates frequently have pressure ulcers, which is why prevention in this type of wound is paramount. Conclusion: Advancements in wound care are rapidly expanding. Various treatments for non-healing wounds in paediatric and neonatal patients have been reported, but high tier evidence in these populations is scarce. We hope to shed light on existing evidence regarding the different therapeutic modalities, from debridement techniques and dressing types to tissue substitutes and topical remedies. There have been promising results in many studies to date, but RCTs involving larger sample sizes are necessary, in order to determine the specific role these innovative agents play in paediatric wounds and to identify true safety and efficacy.
Surgical treatment of midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes: a systematic review
Authors: Ramanujam Crystal L. , Stuto Alan C. , Zgonis Thomas 
Published: June 2020

Objective: A wide range of clinical presentations of Charcot neuroarthropathy of the foot with concomitant osteomyelitis in patients with diabetes has been described. Existing literature provides an equally diverse list of treatment options. The purpose of this systematic review was to assess the outcomes specifically for the surgical management of midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes. Method: A systematic review was conducted by three independent reviewers using the following databases and search engines: Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane Library, EMBASE (Excerpta Medica dataBASE), Google Scholar, Ovid, PubMed and Scopus. Search terms used were: Charcot neuroarthropathy, osteoarthropathy, neuro-osteoarthropathy, neurogenic arthropathy, osteomyelitis, midfoot, foot, ankle, diabetes mellitus, ulceration, wound, infection, surgical offloading, diabetic reconstruction, internal fixation, external fixation. Studies meeting the following criteria were included: English language studies, studies published from 1997–2017, patients with diabetes mellitus surgically treated for Charcot neuroarthropathy of the midfoot (specified location) with concomitant osteomyelitis, with or without internal and/or external fixation, follow-up period of six months or more postoperatively, documentation of healing rates, complications, and need for revisional surgery. Studies which were entirely literature reviews, descriptions of surgical-only technique and/or cadaveric studies, patients without diabetes, studies that did not specify location of osteomyelitis and Charcot neuroarthropathy, and treatment proximal to and including Chopart's/midtarsal joint specifically talonavicular, calcaneocuboid, subtalar, ankle were excluded. Results: A total of 13 selected studies, with a total of 114 patients with diabetes of which 56 had surgical treatment for midfoot Charcot neuroarthropathy with osteomyelitis, met the above inclusion criteria and were used for data extraction. Conclusion: Surgical intervention for midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes demonstrated a relatively high success rate for a range of procedures including debridement with simple exostectomy, arthrodesis with or without internal or external fixation, and advanced soft tissue reconstruction. However, this systematic review emphasises the need for larger, better designed studies to investigate the efficacy and failure rates of surgical treatment in this group of patients.
DISTINGSI KEILMUAN SOSIOLOGI AGAMA (Sejarah Perkembangan, Epistemologi, dan Kontribusi Praksis)
Authors: Soehadha Moh 
Published: June 2020

Sociology studies of religion today have developed in various Islamic colleges in Indonesia. As a science developed in universities, the sociology of religion is built with a strong epistemological foundation. Unlike the sociology of religion developed from sociology in public universities, the sociology of religion in Islamic higher education is also influenced by the Comparative Science of Religion or the Study of Religions. The following article describes the development of religious sociology studies at the UIN Sunan Kalijaga which is distinctive. The distinction of the study of the sociology of religion is influenced by the history of the development of religious sociology study programs and the praxis of religious sociology to solve social and religious problems in Indonesia. Studi sosiologi agama dewasa ini telah berkembang di berbagai perguruan tinggi agama Islam di Indonesia. Sebagai ilmu pengetahuan yang dikembangkan di perguruan tinggi, maka sosiologi agama dibangun dengan landasan epistemologi yang kuat. Berbeda dengan sosiologi agama yang dikembangkan dari ilmu sosiologi yang ada di perguruan tinggi umum, sosiologi agama di perguruan tinggi agama Islam juga dipengaruhi oleh Ilmu Perbandingan Agama atau Studi Agama-agama. Tulisan berikut mendeskripsikan tentang perkembangan studi sosiologi agama di UIN Sunan Kalijaga yang bersifat distingtif. Distingsi kajian sosiologi agama tersebut dipengaruhi oleh sejarah perkembangan program studi sosiologi agama dan kebutuhan praksis sosiologi agama untuk menyelesaikan problem sosial keagamaan di Indonesia.
Assessing “the Religious” and “the Secular” in the Pilgrimage to Gus Dur’s Grave
Authors: Sya'rani Afifur Rochman 
Published: June 2020

Abdurrahman Wahid, well-known as Gus Dur, is the fourth president of Indonesia. He was also the leader of Nahdlatul Ulama’ (NU), the largest Muslim organization in the country. Located in the area of Pesantren (Islamic boarding school) Tebuireng, Jombang, East Java, his grave is one the most visited places for pilgrimage, not only in Java, but also in Indonesia. It is reported that in 2017, “more than 3.000 people visit the grave per day, and can increase three times as much during Saturday and Sunday”. Due to the growing number of visitors, the grave has been renovated, and infrastructural facilities have been built, including the establishment of museum, monument, library, and area of parking. It is noteworthy that pilgrimage to particular religious sites has been called as wisata religi (religious tourism). For example, Gus Dur’s grave has been awarded as the best religious tourism in East Java by Anugerah Wisata Jawa Timur (AWJ) in 2017. This is interesting, as it implies that pilgrimage is not always religious, but also may contain secular instances. This article, thus, seeks to investigate how the religious and the secular go hand in hand in the context of pilgrimage by using Gus Dur’s grave as a case of study. I would argue that the problems should be putted in the context of debate over pilgrimage and tourism, considering that the term wisata religi or religious tourism has been attributed to religious sites and gravesites in particular which have been objectified as a tourist site. Pilgrimage is not merely about religious-based practices, but also about tourist practices. Therefore, this implies that pilgrimage and tourism cannot be viewed in a binary opposition. In the context of global tourism, both are intertwined and overlapped in some ways. In other words, pilgrimage may contain both religious and secular elements. Keywords: Gus Dur’s Grave, Pilgrimage, Tourism, Religious, Secular
Voll- und Reduktionsformen im Dienst der Klammer
Authors: Droste Pepe 
Published: June 2020

Abstract
With rapid increases of token frequency, the formerly weak regular verb haben ›have‹ has been affected by processes of reduction and irregularization that led to a suppletive paradigm in New High German. In contemporary spoken German, haben may even show further reductions, resulting in a short-form paradigm. However, current empirical research documents extensive variation of full and reduced forms in spoken German and provides indications that this variation may be linked to the verbal brace. In this paper, we present the results of a corpus study testing the effects of the verbal brace on the form of haben. We find that the form systematically varies as a function of syntactic position, i.  e. that reduced forms occur when haben is positioned in the left brace and full forms occur when haben is positioned in the right brace. First, a mixed-model regression analysis reveals that the verbal brace has the strongest effect on the variation net of theoretically relevant controls. Second, an interactional-linguistic analysis of deviant cases shows that reduced variants in the right brace are recurrently used for the management of turn-taking. We conclude by discussing the consequences for the paradigm of the verb and how the results shed light on the importance and development-in-progress of the framing principle in German.
Higher-order commutators with power central values on rings and algebras involving generalized derivations
Authors: Ali Shakir , Alhazmi Husain , Khan Abdul Nadim , Raza Mohd Arif 
Published: June 2020

Abstract
Let

ℜ

{\mathfrak{R}}

be a ring with center

Z
⁢

(
ℜ
)

{Z(\mathfrak{R})}

.
In this paper, we study the higher-order commutators with power central values on rings and algebras involving generalized derivations.
Motivated by [A. Alahmadi, S. Ali, A. N. Khan and M. Salahuddin Khan,
A characterization of generalized derivations on prime rings,
Comm. Algebra 44 2016, 8, 3201–3210],
we characterize generalized derivations and related maps that satisfy certain differential identities on prime rings.
Precisely, we prove that if a prime ring of characteristic different from two admitting generalized derivation

𝔉

{\mathfrak{F}}

such that

(

[

𝔉
⁢

(

s
m

)

⁢

s
n

+

s
n

⁢
𝔉
⁢

(

s
m

)

,

s
r

]

k

)

l

∈

Z
⁢

(
ℜ
)

{([\mathfrak{F}(s^{m})s^{n}+s^{n}\mathfrak{F}(s^{m}),s^{r}]_{k})^{l}\in Z(%
\mathfrak{R})}

for every

s
∈
ℜ

{s\in\mathfrak{R}}

, then either

𝔉
⁢

(
s
)

=

p
⁢
s

{\mathfrak{F}(s)=ps}

for every

s
∈
ℜ

{s\in\mathfrak{R}}

or

ℜ

{\mathfrak{R}}

satisfies

s
4

{s_{4}}

and

𝔉
⁢

(
s
)

=

s
⁢
p

{\mathfrak{F}(s)=sp}

for every

s
∈
ℜ

{s\in\mathfrak{R}}

and

p
∈
𝔘

{p\in\mathfrak{U}}

, the Utumi quotient ring of

ℜ

{\mathfrak{R}}

.
As an application, we prove that any spectrally generalized derivation on a semisimple Banach algebra satisfying the above mentioned differential identity must be a left multiplication map.
On the Hochstadt–Lieberman type problem with eigenparameter dependent boundary condition
Authors: Guan Sheng-Yu , Yang Chuan-Fu , Bondarenko Natalia , Xu Xiao-Chuan , Hu Yi-Teng 
Published: June 2020

Abstract
The half-inverse problem is studied for the Sturm–Liouville operator with an eigenparameter dependent boundary condition on a finite interval.
We develop a reconstruction procedure and prove the existence theorem for solution of the inverse problem.
Our method is based on interpolation of entire functions.