bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporary right ventricular circulatory support following right ventricular infarction: results of a groin‐free approach
Authors: Kremer Jamila , Farag Mina , Brcic Andreas , Zubarevich Alina , Schamroth Joel , Kreusser Michael M. , Karck Matthias , Ruhparwar Arjang , Schmack Bastian 
Published: August 2020

AbstractAimsAcute right heart failure (RHF) is a severe complication of right ventricular infarction. The management of acute RHF poses a number of challenges, such as providing haemodynamic support. Temporary circulatory support (TCS) may be required upon failing medical therapy. The ProtekDuo® dual lumen cannula provides a minimally invasive option for (TCS) through a groin‐free internal jugular vein approach. We present the largest patient series to date using the ProtekDuo® cannula as temporary right ventricular assist device (t‐RVAD) in RHF after acute myocardial infarction (MI).Methods and resultsFrom July 2016 to November 2019, 10 patients underwent t‐RVAD implantation for RHF following acute MI. Transthoracic and transoesophageal echocardiography were performed in all patients to assess cardiac function, with a particular focus on RV function. Cumulative 30‐day survival was 60%. Mean TAPSE was 6.4 ± 3.1 mm, mean fractional area change was 12.1 ± 4.2%, and mean right ventricular end diastolic area was 19.8 ± 2.7 cm2. Mean implantation time was 32.8 ± 8.3 min. Mean interval after first cardiac intervention was 4.6 ± 5.8 days. Mean t‐RVAD time was 10.0 ± 7.4 days with a significant reduction in central venous pressure 19.3 ± 2.7 vs. 8.2 ± 2.6 mmHg, P < 0.001 and a significant increase in central venous saturation 52.8 ± 15.6 vs. 80.0 ± 6.0%, P < 0.001. Mean intensive care unit stay was 18.6 ± 12.2 days. Four patients were weaned from TCS. Two patients were bridged to a long‐term paracorporeal RVAD. There were no t‐RVAD associated complications. Causes of death (n = 4) were multiorgan failure, electromechanical dissociation, and haemorrhagic stroke. Mean follow‐up time was 96.0 ± 107.6 days. No independent predictors of mortality were identified in univariate analysis.ConclusionsWe show that groin‐free, percutaneous implantation of the ProtekDuo® cannula is a feasible and safe tool for TCS in acute RHF post‐MI. This approach provides the advantages of percutaneous implantation including complete mobilization and non‐surgical bedside explantation, as well as the option for adding an oxygenator to the t‐RVAD circuit.
Safety evaluation of aqueous extracts of Sanghuangporus vaninii fruiting body in Sprague–Dawley rats
Authors: Huo Jinxi , Sun Yuqing , Zhong Shi , Li Yougui , Yang Ruchun , Xia Lijuan , Wang Jiahong , Zhang Majuan , Zhu Jianxun 
Published: August 2020

AbstractSanghuangporus vaninii, called “Sanghuang,” is orally used for health care, tumor, and inflammation treatment in Asia. However, the safety of S. vaninii has not been evaluated. The major compounds analysis showed that aqueous extracts of S. vaninii fruiting body were rich in polysaccharides, nucleotides, and polyphenols. Then, the aqueous was given orally to Sprague–Dawley rats for toxical test. In acute toxicity study, the maximum tolerated dose was 21 g/kg. In 17‐week repeated dose toxicity experiment, all rats had no abnormal reaction among control group, low dose group (0.15 g/kg) and middle dose group (1.00 g/kg). At high dose group (6.00 g/kg), the feces began to darken on 16th day (D16), and turned to drug stained stool on D21, all rats recovered on the 3rd day (D92) of recovery period. During the whole experiment, there were no animal death and no treatment‐related changes in any of the parameters under the all doses. These results indicated the No‐Observed Adverse Effect Level of aqueous extract of S. vaninii fruiting body was 1.0 g/kg.
MHD nonlinear radiative flow of Carreau nanofluid with variable chemical reaction: An approach to control global warming
Authors: Mishra Ashok , Priyadarsan K. P. , Mishra S. , Nayak M. K. 
Published: August 2020

AbstractSolar energy is a significant source of clean and renewable energy, which can be harnessed to control global warming/pollution levels. Carreau nanofluid models have been used in the cooling of solar devices so as to upgrade the efficiency of solar energy systems. The energy equation is modeled by adopting nonlinear thermal radiation because it has a major role on the solar energy absorption capacity of nanofluid. Diffusion of species involving chemical reactions in boundary layer flow finds overwhelming applications in pollution studies, polymer production, in the design of chemical processing equipments, and so forth. In view of this, the present article is developed to evaluate the impact of nonlinear thermal radiation, chemical reaction, and applied magnetic field to the flow of Carreau nanoliquid induced by exponentially extendable surface. The outcomes of the preset study include that more magnetized the conducting fluid contributes more controlled motion of both shear thinning and shear thickening fluids. Axial and transverse surface viscous drag forces, rate of heat, and mass transportation augment with raising Weissenberg parameter while temperature and concentration fields attain a descending trend due to it. In addition, augmented temperature ratio parameter upgraded the thermal field.
Chronotype and depressive symptoms: A moderated mediation model of sleep quality and resilience in the 1st‐year college students
Authors: Zhou Jieying , Hsiao Fan‐Chi , Shi Xuliang , Yang Jiayu , Huang Yanping , Jiang Yulu , Zhang Bin , Ma Ning 
Published: August 2020

AbstractObjectiveDepression is highly prevalent among 1st‐year college students, and evening chronotype is an important risk factor associated with depression. This study investigates the mediating role of sleep quality and the moderating role of resilience between chronotype and depressive symptoms.MethodsA total of 4531 students were included in this cross‐sectional study. Mediation and moderated mediation models were applied.ResultsThe association between chronotype and depressive symptoms was partially mediated by sleep quality, and the direct and indirect effects were moderated by resilience. The negative correlation between chronotype and depressive symptoms was significant in students with low levels of resilience compared with moderate/high levels. The positive correlation between sleep quality and depressive symptoms was strongest in low‐level resilience students.ConclusionThis study reveals that greater eveningness is associated with poorer sleep quality among 1st‐year college students, which may lead to severer depression, and highlights the importance of resilience training in reducing depressive symptoms.
Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA‐130b‐5p/TLR4/NF‐κB axis
Authors: Wang Dan , Zhao Shixin , Pan Junwei , Wang Zhen , Li Yu , Xu Xiaoxiao , Yang Jiahao , Zhang Xi , Wang Yisheng , Liu Ming 
Published: August 2020

AbstractGinsenoside Rb1 (GRb1), a major ingredient of ginseng, has been found to be a potential protective agent in spinal cord injury (SCI) and in activated microglia‐induced neuronal injury. This study discovered that GRb1 could facilitate miR‐130b‐5p expression in SCI rats and Toll‐like receptor 4 (TLR4; a crucial player in inflammation) was a potential target of miR‐130b‐5p. Hence, we further investigated whether GRb1 could relieve SCI by reducing microglia‐mediated inflammatory responses and neuronal injury via miR‐130b‐5p/TLR4 pathways. The results showed that GRb1 alleviated SCI through inhibiting neuronal apoptosis and proinflammatory factor expression via increasing miR‐130b‐5p.GRb1 weakened the damage of activated microglia to neurons through upregulating miR‐130b‐5p. miR‐130b‐5p attenuated activated microglia‐induced neuron injury via targeting TLR4. GRb1 inactivated TLR4/nuclear factor‐κB (NF‐κB) activation and inhibited proinflammatory cytokine secretion by increasing miR‐130b‐5p in activated microglia. As a conclusion, GRb1 alleviated SCI through reducing activated microglia‐induced neuronal injury via miR‐130b‐5p/TLR4/NF‐κB axis, providing a deep insight into the molecular basis of GRb1 in the treatment of SCI.
Scale‐up Fenton process: study and optimization in piggery wastewater treatment
Authors: Zárate‐Guzmán Ana I , Warren‐Vega Walter M , Romero‐Cano Luis A , Cárdenas‐Mijangos Jesús 
Published: August 2020

AbstractBACKGROUNDIn the present study, the Fenton process was used as an effective method to treat several contaminants present in wastewaters. The case study is a pig farm located in the community of Loma de Zempoala, Guanajuato, Mexico, where the Fenton process in continuos flow assisted with sunlight was used to treat a real piggery wastewater.RESULTSFirst, an optimization of the operational parameters at laboratory scale was carried out by experimental design Taguchi L9. Experimental data showed the following degradation efficiencies: chemical oxygen demand (COD) = 95% ± 1.%; total organic carbon (TOC) = 53% ± 9%; Color = 99% ± 1%. To maximize the degradation of organic matter a Response Surface Methodology (RSM) was employed to define the following operational parameters: pH = 3, reaction time = 60 min, molar ratios hydrogen peroxide (H2O2):COD = 1.5 and H2O2:ferrous ion (Fe2+) = 1.5. As a second step, the scaling of the process in continuous flow was carried out, and the experimental data were adjusted appropriately to a kinetic model of pseudo‐first‐order, reaching a 98% degradation of organic matter at 250 min.CONCLUSIONIn this study, the Fenton process assisted with sunlight is faster than the traditional method because the incident light has a catalytic effect together with the ferric ion, improving the formation of hydroxyl radicals; as a consequence, the treated effluent presents the quality indicated by the Mexican environmental legislation. © 2020 Society of Chemical Industry (SCI)
Chemical shift–based prospective k‐space anonymization
Authors: Mattern Hendrik , Knoll Martin , Lüsebrink Falk , Speck Oliver 
Published: August 2020

PurposePublicly available data provision is an essential part of open science. However, open data can conflict with data privacy and data protection regulations. Head scans are particularly vulnerable because the subject’s face can be reconstructed from the acquired images. Although defacing can impede subject identification in reconstructed images, this approach is not applicable to k‐space raw data. To address this challenge and allow defacing of raw data for publication, we present chemical shift–based prospective k‐space anonymization (CHARISMA).MethodsIn spin‐warp imaging, fat shift occurs along the frequency‐encoding direction. By placing an oil‐filled mask onto the subject’s face, the shifted fat signal can overlap with the face to deface k‐space during the acquisition. The CHARISMA approach was tested for gradient‐echo sequences in a single subject wearing the oil‐filled mask at 7 T. Different fat shifts were compared by varying the readout bandwidth. Furthermore, intensity‐based segmentation was used to test whether the images could be unmasked retrospectively.ResultsTo impede subject identification after retrospective unmasking, the signal of face and shifted oil should overlap. In this single‐subject study, a shift of 3.3 mm to 4.9 mm resulted in the most efficient masking. Independent of CHARISMA, long TEs induce signal decay and dephasing, which impeded unmasking.ConclusionTo our best knowledge, CHARISMA is the first prospective k‐space defacing approach. With proper fat‐shift direction and amplitude, this easy‐to‐build, low‐cost solution impaired subject identification in gradient‐echo data considerably. Further sequences will be tested with CHARISMA in the future.
Time Delay of Initiation of some Primary Explosives and Initiating Mixtures when Exposed to Continuous IR Laser Radiation
Authors: Kolesov Vasily I. , Konovalov Alexey N. , Manakhova Ekaterina S. , Ul'yanov Valery A. , Yudin Nikolay V. 
Published: August 2020

AbstractLaser initiation of energetic materials is a topic of significant interest. An extremely important parameter of initiation for numerous applied tasks is the time delay of initiation from the beginning of laser exposure. Experimental studies of the process of initiation of a number of primary explosives (lead styphnate (LS), lead azide, (LA)) and initiating mixtures (potassium perchlorate and potassium hexacyanoferrate (III) (PP/PH), bismuth oxide and aluminum ‐ nanothermite (NT)) under the exposure of a continuous IR (0.915 μm) laser with a power of up to 10 W were carried out. The time delay of initiation of these explosives was measured. It is shown that nanothermite (NT) has the lowest time delays and minimal initiation thresholds. At a laser power of 1 W and a light spot diameter of 0.5 mm (intensity 0.5 kW / cm2) the time delay of NT initiation was 1.2–1.8 ms. For other explosives with such a laser spot diameter, the initiation threshold was 2–3 W (1–1.5 kW/cm2). It is shown that mixtures of these explosives photosensitized by 0.5 % nanoaluminum have an initiation threshold ten times lower than for pure materials. For such compositions, the initiation time delay was 2–10 ms at the laser radiation intensity of 0.5 kW/cm2. It was found that for the PP/PH material there is a certain limit on the minimum time delay of initiation, which was 0.1–0.15 ms. It is suggested that this effect is associated with the micro‐hotspot nature of laser initiation of EM and the presence of a critical zone of initiation.
Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient‐derived primary prostate cells
Authors: Naeem Aisha , Dakshanamurthy Sivanesan , Walthieu Henry , Parasido Erika , Avantaggiati Maria , Tricoli Lucas , Kumar Deepak , Lee Richard J. , Feldman Adam , Noon Muhammad S. , Byers Stephen , Rodriguez Olga , Albanese Chris 
Published: August 2020

AbstractBackgroundDrug repurposing enables the discovery of potential cancer treatments using publically available data from over 4000 published Food and Drug Administration approved and experimental drugs. However, the ability to effectively evaluate the drug's efficacy remains a challenge. Impediments to broad applicability include inaccuracies in many of the computational drug‐target algorithms and a lack of clinically relevant biologic modeling systems to validate the computational data for subsequent translation.MethodsWe have integrated our computational proteochemometric systems network pharmacology platform, DrugGenEx‐Net, with primary, continuous cultures of conditionally reprogrammed (CR) normal and prostate cancer (PCa) cells derived from treatment‐naive patients with primary PCa.ResultsUsing the transcriptomic data from two matched pairs of benign and tumor‐derived CR cells, we constructed drug networks to describe the biological perturbation associated with each prostate cell subtype at multiple levels of biological action. We prioritized the drugs by analyzing these networks for statistical coincidence with the drug action networks originating from known and predicted drug‐protein targets. Prioritized drugs shared between the two patients’ PCa cells included carfilzomib (CFZ), bortezomib (BTZ), sulforaphane, and phenethyl isothiocyanate. The effects of these compounds were then tested in the CR cells, in vitro. We observed that the IC50 values of the normal PCa CR cells for CFZ and BTZ were higher than their matched tumor CR cells. Transcriptomic analysis of CFZ‐treated CR cells revealed that genes involved in cell proliferation, proteases, and downstream targets of serine proteases were inhibited while KLK7 and KLK8 were induced in the tumor‐derived CR cells.ConclusionsGiven that the drugs in the database are extremely well‐characterized and that the patient‐derived cells are easily scalable for high throughput drug screening, this combined in vitro and in silico approach may significantly advance personalized PCa treatment and for other cancer applications.
Künstliche Intelligenz zur Unterstützung der Telemedizin am Beispiel Afrikas
Authors: Greis C. , Maul L. V. , Hsu C. , Djamei V. , Schmid-Grendelmeier P. , Navarini A. A. 
Published: August 2020

ZusammenfassungTelemedizin findet seit Jahrzehnten Anwendung im Alltag von Dermatologen. Insbesondere in afrikanischen Ländern mit begrenzter medizinischer Versorgung, zu überbrückenden geografischen Distanzen und einem zwischenzeitlich relativ gut ausgebauten Telekommunikationssektor liegen die Vorteile auf der Hand. Nationale und internationale Arbeitsgruppen unterstützen den Aufbau von teledermatologischen Projekten und bedienen sich in den letzten Jahren zunehmend KI(künstliche Intelligenz)-gestützter Technologien, um Ärzte vor Ort zu unterstützen. Vor diesem Hintergrund stellen ethnische Variationen eine besondere Herausforderung in der Entwicklung automatisierter Algorithmen dar. Um die Genauigkeit der Systeme weiter zu verbessern und globalisieren zu können, ist es wichtig, die Zahl der verfügbaren klinischen Daten zu erhöhen. Dies kann nur mit der aktiven Beteiligung der lokalen Gesundheitsversorger sowie der dermatologischen Gemeinschaft gelingen und muss stets im Interesse des einzelnen Patienten erfolgen.
Roboterassistierte (RA-)Kinderchirurgie: Nierenbeckenplastiken mit dem Da-Vinci-Roboter
Authors: Ammer E. , Kahl Dr. F. 
Published: August 2020

Zusammenfassung
Hintergrund
Im Ausland stellt die roboterassistierte (RA-)Chirurgie und hier besonders die RA-Urologie in der Kinderchirurgie bereits eine wichtige Alternative zu konventionellen Eingriffen (offen, laparoskopisch, laparoskopisch-assistiert) dar. Für Deutschland wurden dazu erst wenige Untersuchungen publiziert.

Ziel der Arbeit (Fragestellung)
Im Sinne einer vergleichenden Serie sollten die ersten Fälle von RA-Nierenbecken-Plastiken der Kinderchirurgie der Universitätsmedizin Göttingen im Vergleich zu konventionell laparoskopisch-assistierten (LAA) vor dem Hintergrund der internationalen Literatur evaluiert werden.

Material und Methoden
Es werden retrospektiv die ersten 13 RA und 14, unter Berücksichtigung des Patientenalters ausgewählte, konventionell LAA Anderson-Hynes-Plastiken hinsichtlich Operationsdauer, Krankenhausverweildauer, Alter der Patienten, Komplikationen und Rezidiven untersucht. Laparoskopisch-assistierte Operationen werden laparoskopisch durchgeführt, lediglich die Anlage der Anastomose erfolgt über einen kleinen Flankenschnitt extrakorporal. Roboterassistierte Eingriffe verlaufen gänzlich laparoskopisch.

Ergebnisse
Für die Operationsdauer ergab sich kein signifikanter Unterschied (111,54 min vs. 117,64 min). Die Liegezeit fiel für RA-Eingriffe signifikant kürzer aus (5,85 Tage vs. 10,0 Tage). Die Altersverteilung ergab für die RA-Kohorte ein Mittel von 52,23 Monaten und für die LAA 30,29 Monate. Die Komplikationsrate betrug 15,38 % (Harntransportstörung, paralytischer Ileus und Dislokation des PDK sowie Omentumprolaps), die Rezidivrate 7,69 % für die RA Eingriffe. Für die LAA operierten Patienten und Patientinnen lagen die Werte bei 7,14 % (Dislokation der Doppel-J-Schiene nach kranial) und 14,28 %.

Diskussion
Die ersten RA-Nierenbecken-Plastiken unserer Klinik wiesen im internationalen Vergleich ähnliche Werte für Operationsdauer, Komplikations- sowie Rezidivrate auf. Es zeigten sich ein ähnliches Outcome für beide Operationsverfahren und keine signifikante Zeitersparnis durch Verwendung des OP-Roboters. Im Gegensatz dazu fiel die Krankenhausverweildauer nach RA-Eingriffen signifikant kürzer aus als nach LAA-Operationen. In der internationalen Literatur finden sich jedoch auch insgesamt kürzere Liegezeiten. Insgesamt stellen RA-Nierenbecken-Plastiken eine wertvolle Alterative zu LAA-Verfahren dar.
Improvements of the coupled WRF-Lake model over Lake Nam Co, Central Tibetan Plateau
Authors: Wu Yang , Huang Anning , Lazhu  , Yang Xianyu , Qiu Bo , Wen Lijuan , Zhang Zhiqi , Fu Zhipeng , Zhu Xueyan , Zhang Xindan , Cai Shuxin , Tang Yong 
Published: August 2020

AbstractA series of model sensitivity simulations are carried out to calibrate and improve the Weather Research and Forecasting Model coupled with a one-dimensional lake model (WRF-Lake) based on observations over Lake Nam Co. Using the default lake model parameters, the solution of WRF-Lake exhibits significant biases in both the lake thermodynamics and regional climatology, i.e., higher lake surface temperature (LST), earlier onset of summer thermal stratification, and overestimated near-surface air temperature and precipitation induced by the lake’s excessive warming and moistening impacts. The performance of WRF-Lake is improved through adjusting the initial lake temperature profile, the temperature of maximum water density (Tdmax), the surface roughness length, and the light extinction coefficient. Results show that initializing the water temperature with spring observation mitigates the LST overestimation and reduces the timing error of the onset of thermal stratification. By further adjusting Tdmax from 4 °C to the observed value of 3.5 °C, the LST increase from June to mid-July is enhanced and the buildup of thermal stratification is more accurately predicted. Through incorporating the parameterized surface roughness length and decreasing the light extinction coefficient, the model better reproduces the observed daily evolution of LST and vertical lake temperature profile. The calibrated WRF-Lake effectively mitigates the overestimation of over-lake air temperature at 2 m height and precipitation over regions downwind the lake. This suggests that an improved lake scheme within the coupled WRF-Lake is essential for realistically simulating the lake–air interactions and the regional climate over the lake-rich Tibetan Plateau.
How to raise technology acceptance: user experience characteristics as technology-inherent determinants
Authors: Mlekus Lisa , Bentler Dominik , Paruzel Agnieszka , Kato-Beiderwieden Anna-Lena , Maier Günter W. 
Published: August 2020

AbstractThis paper in the journal “Gruppe. Interaktion. Organisation. (GIO)” presents a study that investigated user experience characteristics as determinants of technology acceptance. Organizations planning to implement new technologies are confronted with the challenge to ensure user acceptance. Barely accepted technologies are used less often, result in lower job satisfaction, and ultimately lead to performance losses. The technology acceptance model (Venkatesh and Bala 2008) incorporates determinants of information technology use. The model’s predictors have a strong focus on interindividual user characteristics (such as computer self-efficacy) and the job context (e.g., voluntariness). Yet, what is lacking in the model, are characteristics of the technology itself that can be used as starting points to design better technologies. To bridge this gap, we introduce the User Experience Technology Acceptance Model, and provide a first test of this model. In our online survey (N = 281), we investigated how technological determinants, more specifically user experience characteristics, affected technology acceptance. Except for two paths of our proposed model, all path coefficients were significant with small to large effect sizes (f2 = 0.02–0.66). User experience predictors resulted in 60.6% of explained variance in perceived ease of use, 38.2% of explained variance in perceived usefulness, and 25.8% of explained variance in behavioral intention. Our results provide mostly support for our extension of the technology acceptance model. The technology-inherent characteristics output quality, perspicuity, dependability, and novelty were significant predictors of technology acceptance. We discuss theoretical and practical implications with the focus on technology designers, change managers, and users.