bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breaking down of healthcare system: Mathematical modelling for controlling the novel coronavirus (2019-nCoV) outbreak in Wuhan, China
Authors: Ming Wai-Kit , Huang Jian , Zhang Casper J. P. 
Published: January 2020

AbstractBackgroundA novel coronavirus pneumonia initially identified in Wuhan, China and provisionally named 2019-nCoV has surged in the public. In anticipation of substantial burdens on healthcare system following this human-to-human spread, we aim to scrutinise the currently available information and evaluate the burden of healthcare systems during this outbreak in Wuhan.Methods and FindingsWe applied a modified SIR model to project the actual number of infected cases and the specific burdens on isolation wards and intensive care units (ICU), given the scenarios of different diagnosis rates as well as different public health intervention efficacy. Our estimates suggest, assuming 50% diagnosis rate if no public health interventions were implemented, that the actual number of infected cases could be much higher than the reported, with estimated 88,075 cases (as of 31stJanuary, 2020), and projected burdens on isolation wards and ICU would be 34,786 and 9,346 respectively The estimated burdens on healthcare system could be largely reduced if at least 70% efficacy of public health intervention is achieved.ConclusionThe health system burdens arising from the actual number of cases infected by the novel coronavirus appear to be considerable if no effective public health interventions were implemented. This calls for continuation of implemented anti-transmission measures (e.g., closure of schools and facilities, suspension of public transport, lockdown of city) and further effective large-scale interventions spanning all subgroups of populations (e.g., universal facemask wear) aiming at obtaining overall efficacy with at least 70% to ensure the functioning of and to avoid the breakdown of health system.
Integrin β3, a RACK1 interacting protein, is required for porcine reproductive and respiratory syndrome virus infection and NF-κB activation in Marc-145 cells
Authors: Yang Chao , Lan Rui , Wang Xiaochun , Zhao Qian , Li Xidan , Bi Junlong , Wang Jing , Yang Guishu , Lin Yingbo , Liu Jianping , Yin Gefen 
Published: January 2020

ABSTRACTPorcine reproductive and respiratory syndrome virus (PRRSV) is the pathogen of porcine reproductive and respiratory syndrome (PRRS), which is one of the most economically harmful diseases in modern pig production worldwide. Receptor of activated protein C kinase 1 (RACK1) was previously shown to be indispensable for the PRRSV replication and NF-κB activation in Marc-145 cells. Here we identified a membrane protein, integrin β3 (ITGB3), as a RACK1-interacting protein. PRRSV infection in Marc-145 cells upregulated the ITGB3 expression. Abrogation of ITGB3 by siRNA knockdown or antibody blocking inhibited PRRSV infection and NF-κB activation, while on the other hand, overexpression of ITGB3 enhanced PRRSV infection and NF-κB activation. Furthermore, inhibition of ITGB3 alleviated the cytopathic effects and reduced the TCID50titer in Marc-145 cells. We also showed that RACK1 and ITGB3 were NF-κB target genes during PRRSV infection, and that they regulate each other. Our data indicate that ITGB3, presumably as a co-receptor, plays an imperative role for PRRSV infection and NF-κB activation in Marc-145 cells. PRRSV infection activates a positive feedback loop involving the activation of NF-κB and upregulation of ITGB3 and RACK1 in Marc-145 cells. The findings would advance our elaborated understanding of the molecular host–pathogen interaction mechanisms underlying PRRSV infection in swine and suggest ITGB3 and NF-κB signaling pathway as potential therapeutic targets for PRRS control.IMPORTANCEPorcine reproductive and respiratory syndrome virus (PRRSV) is one of the pathogens in pig production worldwide. Several cell surface receptors, such as heparan sulphate, sialoadhesin, vimentin and CD163, were identified to be involved in PRRSV infection in porcine alveolar macrophages (PAMs). We identified a cell surface protein, integrin β3 (ITGB3), as an interacting protein with receptor of activated protein C kinase 1 (RACK1) from Marc-145 cells. ITGB3 interacts with RACK1 and facilitates PRRSV infection and NF-κB activation in Marc-145 cells, presumably as a co-receptor of CD136 or vimentin. Both ITGB3 and RACK1 were NF-κB target genes, and they regulate each other. The activation of NF-κB and the transcription of its downstream genes are beneficial for PRRSV infection/replication. The novel findings would advance our elaborated understanding of the molecular host–pathogen interaction mechanisms underlying PRRSV infection in swine and suggest ITGB3-RACK1-NF-κB axis as a potential therapeutic target for PRRS control.
Survival of environmental DNA in sediments: Mineralogic control on DNA taphonomy
Authors: Freeman C.L. , Dieudonné L. , Agbaje O.B.A. , Zure M. , Sanz J.Q. , Collins M. , Sand K.K. 
Published: January 2020

AbstractExtraction of environmental DNA (eDNA) from sediments are providing ground-breaking views of the past ecosystems and biodiversity. Despite this rich source of information, it is still unclear which sediments favour preservation and why. Here we used atomic force microscopy and molecular dynamics simulations to explore the DNA-mineral interaction to assess how mineralogy and interfacial geochemistry play a role in the preservation of environmental DNA on mineral substrates. We demonstrate that mineral composition, surface topography and surface charge influence DNA adsorption behavior as well as preservation. Modeling and experimental data show that DNA damage can be induced by mineral binding if there is a strong driving force for adsorption. The study shows that knowledge of the mineralogical composition of a sediment and the environmental conditions can be useful for assessing if a deposit is capable of storing extracellular DNA and to what extent the DNA would be preserved. Our data adds to the understanding of eDNA taphonomy and highlights that, for some mineral systems, fragmented DNA may not represent old DNA.
Who is more entrepreneurial? A comparative study of vocational and academic students
Authors: Bhattacharyya Arun , Kumar Narottam 
Published: January 2020

Purpose
Research in the context of an individual’s choice of an entrepreneurial career has looked at effect of perceived self-efficacy (PSE), personality characteristics (PC) and subjective norms on entrepreneurial intentions (EIs). In contrast, the purpose of this paper is to compare these constructs across a vocational student (VC) group and an academic group (AC), in a supportive entrepreneurial ecosystem. It also includes PC of the individuals as a variable.

Design/methodology/approach
The analysis is based on a quantitative method followed by a qualitative approach to gain more insights in the study domain. It includes administration of a survey questionnaire and a round of unstructured interviews with select students.

Findings
Theorizing that there would be significant differences in PSE, PC and EIs between the two groups, the study demonstrates that for all the three variables, individuals opting for a vocational course exhibit significant difference as compared to an academic group. The results are significant when controlled for family business background and gender.

Originality/value
This paper has contributed to the academic literature in the entrepreneurship domain by differentiating the choice of an academic course prior to taking up a career in entrepreneurship and how it impacts entrepreneurial orientations. These interrelationships can further be extended into the domain of social media and networks, to draw interesting insights pertaining to how students get influenced by the social media in their choice of entrepreneurial career.
Use of electronic resources by law academics: a case study from the University of Namibia
Authors: Leonard Anna , Hamutumwa Nampa Meameno , Mnubi-Mchombu Chiku 
Published: January 2020

Purpose
The purpose of this paper is to examine the use of e-resources by the Faculty of Law’s academic staff at the University of Namibia’s (UNAM’s) main campus. The study aimed to determine their level of awareness of electronic resources (e-resources) available to them, how useful and effective they found these e-resources, and the challenges they face in accessing them.

Design/methodology/approach
A convenient sampling technique was used to select a sample of 12 law academics from the population of 17. The study used both qualitative and quantitative research methods using questionnaires and a semi-structured interview guide.

Findings
Findings revealed that the majority of the law academics were aware of the e-resources subscribed by UNAM’s library, although some were not aware of the newly subscribed international law databases. The findings further revealed that the academics used e-resources for research, publications and teaching purposes, but irregular training, bandwidth problems and limited searching skills hindered their use of e-resources.

Practical implications
Findings could be used to inform future collection-development decisions, realignment of information-literacy training and promotion and marketing of library services.

Originality/value
This study has made a significant contribution in the understanding the use of electronic legal resources by law academics at UNAM. The findings and recommendations could also benefit similar academic institutions in developing countries like Namibia.
Collection management of electronic resources in engineering college libraries of Aligarh, India: a study
Authors: Muzamil Mushtaq Muzamil Mushtaq , Ariba Tausif Ariba Tausif 
Published: January 2020

Purpose
The purpose of this paper is to analyze the e-resource collection development practices of the engineering college libraries of Aligarh. The research includes budgeting, collection development policy, collection evaluation, sources of funds, modes of procurement, pricing models and other aspects related to collection development activity.

Design/methodology/approach
The descriptive method was used for conducting the study, in which a well-structured questionnaire was administered followed by interview of the librarians of six engineering college libraries under study.

Findings
It was found that these colleges are much more interested in focusing on building a strong e-resource collection in their libraries. During the past few years, the budget has also been increased in majority of libraries for the acquisition of e-resources. The study found that the major factors affecting the selection of electronic resources (e-resources) in these colleges are quality, subject coverage, license agreement and vendor support. It was also revealed that majority of libraries lack proper collection development policy, especially for e-resources. The study suggested that these libraries should build their collections keeping in mind the different areas of specializations of engineering studies and the contemporary changes in the field.

Research limitations/implications
The paper is restricted exclusively to the study of collection development process of e-resources and the librarians of six major engineering colleges of Aligarh as respondents.

Practical implications
This study has great importance for the librarians of the similar engineering colleges in India. The findings and suggestions of the study can help not only in understanding the engineering college librarianship and its current trends but can also help library professionals who are facing similar challenges in their libraries.

Originality/value
The present study is about the e-resource collection development practices followed in engineering colleges of Aligarh, which can serve as a pedestal for future studies in other academic and special libraries in India and elsewhere.
Authentically, proudly ethical
Authors: Septianto Felix , Tjiptono Fandy , Arli Denni 
Published: January 2020

Purpose
Prior research suggests that consumers can engage in moral decoupling by separating their judgments of morality from their judgments of performance. Hence, they might rationalize the benefits of unethical behavior without condoning the behavior itself. This paper aims to study how a discrete positive emotion, such as authentic pride, can mitigate moral decoupling.

Design/methodology/approach
Using three experimental studies, this research investigates and tests the underlying mechanism driving authentic pride, its effects and its key moderator. The results are analyzed using ANOVAs, regression-based serial mediation and moderated mediation analyses.

Findings
The results show that authentic pride decreases consumer acceptance of unethical behavior across different contexts, including purchase intentions for unethically manufactured products (Study 1), evaluations of the corporate social responsibility activities of a tobacco company (Study 2) and acceptance of questionable consumer behavior in daily situations (Study 3).

Research limitations/implications
This research explores attitudes and behavioral intentions as dependent variables. It would thus be of interest for future research to examine a behavioral measure.

Practical implications
Given the potential problems of moral decoupling among consumers, marketers can devise effective strategies to reduce this problem using authentic pride appeals.

Originality/value
This research demonstrates how authentic pride can decrease consumer acceptance of unethical behavior. More importantly, this research enriches our understanding of the underlying mechanism driving the influence of authentic pride such that it increases the belief in a just world, which in turn lowers moral decoupling (a serial mediation).
Work and non-work identities in global virtual teams
Authors: Shaik Farheen Fathima , Makhecha Upam Pushpak , Gouda Sirish Kumar 
Published: January 2020

PurposeIncreasing digitization has transformed ways of work in modern age. Organizations are increasingly relying on global virtual teams (GVTs) as new forms of working. However, the challenges of configuration of GVTs have been reported to reduce the levels of employee engagement, especially so in multicultural GVTs. Extant research indicates cultural intelligence as one of the drivers of employee engagement in GVTs, though the nature of this relationship has remained unclear. As there is scarce literature on the nature of this relationship, the purpose of this paper is to examine the linkages between cultural intelligence and employee engagement and the authors explain the findings using the identity lens.Design/methodology/approachThis study is an ethnographic inquiry to understand the nature of the relationship between cultural intelligence and employee engagement.FindingsThe results of the study indicate that the inclusionary pressures of non-work identities (national culture) are high in context of GVTs owing to their configuration. However, preferences (alignment or misalignment) of team members either initiate gain cycles or loss cycles, thus effecting the levels of employee engagement. Further, it was found that individual preferences may dynamically change from misalignment toward alignment with improved levels of cultural intelligence among team members of GVTs. The relationship between cultural intelligence and employee engagement has been found to be mediated by trust among team members in GVTs.Originality/valueThis is one of the first papers to understand the dynamics of this relationship in an organizational GVT context. The authors also propose a unique framework combining cultural intelligence, trust and employee engagement in the context of GVTs.
To switch or not to switch: the role of tourists’ psychological engagement in the context of Airbnb Malaysia
Authors: Tiamiyu Tosin , Quoquab Farzana , Mohammad Jihad 
Published: January 2020

Purpose
The demand for Airbnb is at a peak in Malaysia with 137% of yearly growth. As such, it is indeed important to understand what makes tourists to switch to Airbnb. However, little has been known about this issue in the existing literature. Considering this, the present study aims to shed some light on the factors that drive tourists to switch to Airbnb. More specifically, the objectives of this study are to examine the direct effects of price unfairness and alternative attractiveness on psychological engagement, and to examine the direct effect as well as the mediating effect of psychological engagement towards tourists’ switching intention in the context of Malaysian Airbnb.

Design/methodology/approach
By considering the attribution theory, this study developed and tested a framework to examine tourists’ switching intentions. A Web-based survey was designed to collect the data which yielded 162 complete and usable responses. Structural equation modelling, more particularly, partial least squares (SmartPLS, version 3) technique was used to analyze the data.

Findings
The results revealed that price unfairness negatively affects psychological engagement, which in turn negatively affects tourists’ switching intention. However, no significant relationship was found between alternative attractiveness and psychological engagement. Additionally, psychological engagement mediated the relationship between “price unfairness and tourists’ switching intention”, but not between “alternative attractiveness and tourists’ switching intention.”

Practical implications
It is expected that the findings of this study will enable the hoteliers to better understand the impact of perceived unfairness, alternative attractiveness and psychological engagement in provoking tourists to switch to Airbnb services. It eventually will assist them in improving their offerings and services accordingly.

Originality/value
The discussion on Airbnb is quite new in the tourism literature. This study is among the pioneers to highlight the switching intention towards Airbnb in the Malaysian market. Guided by the attribution theory, this study developed and tested comparatively new linkages. More specifically, no prior study has considered psychological engagement as the antecedent of the switching intention which this study attempted to address. Additionally, this is a prior study that examines the mediating effect of psychological engagement between price unfairness, alternative attractiveness and switching intention.
Content marketing in e-commerce platforms in the internet celebrity economy
Authors: Geng Ruibin , Wang Shichao , Chen Xi , Song Danyang , Yu Jie 
Published: January 2020

Purpose
With the popularity of social media and, recently, live streaming, internet celebrity endorsements have become a prevalent approach to content marketing for e-commerce sellers. Despite the widespread use of social media and online communities, empirical studies investigating the economic value of user-generated content (UGC) and marketer-generated content (MGC) still lag behind. The purpose of this paper is to contribute both theoretically and practically to capture both first-order effects and second-order effects of internet celebrity endorsements on marketing outcomes in an e-commerce context.

Design/methodology/approach
This study conducts a cross-sectional regression to evaluate the economic value of internet celebrity endorsement, and a panel vector autoregressive model is adopted to examine the relationship between celebrities’ and consumers’ content marketing behaviors and e-commerce sales performance. The authors also adopt look-ahead propensity-score matching technique to correct for selection bias.

Findings
The empirical results show that the content generation efforts of marketers and the interaction behaviors between marketers and consumers will significantly influence the e-commerce sales, which refers to the first-order effects of internet celebrity endorsement. Moreover, interactions within the fan community exert second-order effects of content marketing on sales performance.

Originality/value
This paper provides new insights for e-commerce retailers to evaluate the economic values of internet celebrity endorsement, a new content marketing practice in e-commerce platform.
Assessing the university student perceived learning gains in generic skills
Authors: Chow Joseph , Tse Ada , Armatas Christine 
Published: January 2020

Purpose
The purpose of this paper is to report undergraduate students’ learning gains in six areas of generic skills. The paper reports on students’ responses to the First Year Experience (FYE) Survey completed at the end of their first year and Graduating Student Survey (GSS) in the final semester of their final year.

Design/methodology/approach
In this study, a longitudinal design was applied in data collection, analysis and reporting of assessment if student learning gains. The undergraduate students who were the first cohort of four-year curriculum students in a Hong Kong university were selected as the sample. Repeated measures of reported learning gains of a longitudinal sample based on stacking of both FYE and GSS data were analysed using the Rasch model.

Findings
The results showed that the scale for measuring the six areas of generic skills had high reliability and good person separation. Comparison of repeated measures from the same group of students at the two time points were examined to explore whether there is growth in the generic skills during their university studies.

Research limitations/implications
One limitation of the study was the relatively small sample size of 359 students in one higher education institution.

Practical implications
The findings of the study provide insight into conceptual understanding and measurement of university student learning gains.

Originality/value
Whilst several studies have investigated university student learning gains, there is limited research which explores the use Rasch modelling in assessment of student learning gains in multiple areas towards completion of their undergraduate studies.
In plain sight – developing strategic responses to corporatised organised crime
Authors: Murray Kenneth 
Published: January 2020

Purpose
This paper aims to consider the ways organised crime exerts influence in legitimate commercial markets through its ability to act through corporate vehicles. Discussion of weaknesses in company registration procedures and the criminal justice system that enable this to happen. Development of strategic rather than tactical responses is proposed to counter it.

Design/methodology/approach
The paper presents case studies based on practitioner experience and discusses points that arise.

Findings
This paper considers the extent to which the problem represents a threat to the well-being and competitiveness of domestic commercial markets and how these threats can be most effectively addressed.

Research limitations/implications
This is a point of view paper authored by a practitioner with professional expertise in the field.

Practical implications
There is a need to develop strategic cross-agency responses to this problem. This will develop better levels of precautionary awareness of how these influences can establish footholds in commercial markets and provide a sounder basis for taking effective measures to contain and counter their influence.

Social implications
The social implications relate to the distorting influence of money derived from crime being deployed in legitimate spheres.

Originality/value
The originality/value of this paper is to raise awareness and re-invigorate discussion on the influence of organised crime in legitimate commercial markets.