bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer
Authors: Cardenas Horacio , Jiang Guanglong , Thomes Pepin Jessica , Parker J. Brandon , Condello Salvatore , Nephew Kenneth P. , Nakshatri Harikrishna , Chakravarti Debabrata , Liu Yunlong , Matei Daniela 
Published: December 2019

AbstractLoss-of-function mutations of the breast cancer type 1 susceptibility protein (BRCA1) are associated with breast (BC) and ovarian cancer (OC). To identify gene signatures regulated by epigenetic mechanisms in OC cells carrying BRCA1 mutations, we assessed cellular responses to epigenome modifiers and performed genome-wide RNA- and chromatin immunoprecipitation-sequencing in isogenic OC cells UWB1.289 (carrying a BRCA1 mutation, BRCA1-null) and UWB1.289 transduced with wild-type BRCA1 (BRCA1+). Increased sensitivity to histone deacetylase inhibitors (HDACi) was observed in BRCA1-null vs. BRCA1+ cells. Gene expression profiles of BRCA1-null vs. BRCA1+ cells and treated with HDACi were integrated with chromatin mapping of histone H3 lysine 9 or 27 acetylation. Gene networks activated in BRCA1-null vs. BRCA1 + OC cells related to cellular movement, cellular development, cellular growth and proliferation, and activated upstream regulators included TGFβ1, TNF, and IFN-γ. The IFN-γ pathway was altered by HDACi in BRCA1+ vs. BRCA1-null cells, and in BRCA1-mutated/or low vs. BRCA1-normal OC tumors profiled in the TCGA. Key IFN-γ-induced genes upregulated at baseline in BRCA1-null vs. BRCA1+OC and BC cells included CXCL10, CXCL11, and IFI16. Increased localization of STAT1 in the promoters of these genes occurred in BRCA1-null OC cells, resulting in diminished responses to IFN-γ or to STAT1 knockdown. The IFN-γ signature was associated with improved survival among OC patients profiled in the TCGA. In all, our results support that changes affecting IFN-γ responses are associated with inactivating BRCA1 mutations in OC. This signature may contribute to altered responses to anti-tumor immunity in BRCA1-mutated cells or tumors.
Lightning electric‐field waveforms associated with transmission‐line faults
Authors: Cai Li , Zou Xin , Wang Jianguo , Li Quanxin , Zhou Mi , Fan Yadong , Yu Wenbo 
Published: December 2019

The radiated electric field produced by lightning plays a vital role in lightning location systems (LLSs). The presence of the elevated objects, i.e. transmission lines in the presented study, result in an increase of amplitude and multiple sub‐peaks in the observed electric fields. On the basis of the electric fields obtained from multiple sensors of Foshan total LLS, electric fields from nine negative lightning strokes associated with transmission‐line faults at a distance of 10–86 km in Foshan area were examined in detail, which were adopted to make comparison with the radiated electric fields from natural negative cloud‐to‐ground lightning detected nearby within 1 min. It can be found that the arithmetic means (AMs) of initial electric‐field peak values of waveforms associated with transmission‐line faults are about twice those of natural negative lightning and the second and third sub‐peaks can be identified obviously. In addition, the correlation between electric‐field waveform characteristics and propagation distance was validated. The AM zero‐crossing time, fast‐transition 10–90% rise time and the time interval between sub‐peaks slightly increase with distance.
An ALMA/NOEMA study of gas dissipation and dust evolution in the 5 Myr-old HD 141569A hybrid disc
Authors: Di Folco E. , Péricaud J. , Dutrey A. , Augereau J.-C. , Chapillon E. , Guilloteau S. , Piétu V. , Boccaletti A. 
Published: December 2019

Context.The study of gas-rich debris discs is fundamental to characterising the transition between protoplanetary discs and debris discs.Aims.We determine the physical parameters of the brightest gas-rich debris disc orbiting HD 141569A.Methods.We analyse images from the NOrthern Extended Millimeter Array (NOEMA)1and the Atacama Large Millimeter/ submillimeter Array (ALMA) in12CO,13COJ= 2 → 1, and13COJ= 1 → 0 transitions. We incorporate ALMA archival data of the12COJ= 3 → 2 transition and present continuum maps at 0.87, 1.3, and 2.8 mm. We use simple parametric laws with the Diskfit code and MCMC exploration to characterise the gas disc parameters and report a first attempt to characterise its chemical content with IRAM-30 m.Results.The continuum emission is equally shared between a compact (≲50 au) and a smooth, extended dust component (~350 au). Large millimetre grains seem to dominate the inner regions, while the dust spectral index is marginally larger in the outer region. The12CO is optically thick, while13CO is optically thin withτ13CO~ 0.15 (C18O is not detected). The13CO surface density is constrained to be one order of magnitude smaller than around younger Herbig Ae stars, and we derive a gas massM12CO= 10−1M⊕. We confirm the presence of a small CO cavity (RCO= 17 ± 3 au), and find a possibly larger radius for the optically thin13COJ= 2 → 1 transition (35 ± 5 au). We show that the observed CO brightness asymmetry is coincident with the complex ring structures discovered with VLT/SPHERE in the inner 90 au. The12CO temperatureT0(100 au) ~ 30 K is lower than expected for a Herbig A0 star, and could be indicative of subthermal excitation.Conclusions.With the largest amount of dust and gas among hybrid discs, HD 141569A shows coincident characteristics of both protoplanetary discs (central regions), and debris discs at large distance. Together with its morphological characteristics and young age, it appears to be a good candidate to witness the transient phase of gas dissipation, with an apparently large gas-to-dust ratio (G∕D> 100) favouring a faster evolution of dust grains.
MASCARA-4 b/bRing-1 b: A retrograde hot Jupiter around a bright A-type star
Authors: Dorval P. , Talens G. J. J. , Otten G. P. P. L. , Brahm R. , Jordán A. , Torres P. , Vanzi L. , Zapata A. , Henry T. , Paredes L. , Jao W. C. , James H. , Hinojosa R. , Bakos G. A. , Csubry Z. , Bhatti W. , Suc V. , Osip D. , Mamajek E. E. , Mellon S. N. , Wyttenbach A. , Stuik R. , Kenworthy M. , Bailey J. , Ireland M. , Crawford S. , Lomberg B. , Kuhn R. , Snellen I. 
Published: December 2019

Context. The Multi-site All-Sky CAmeRA (MASCARA) and bRing are both photometric ground-based instruments with multiple stations that rely on interline charge-coupled devices with wide-field lenses to monitor bright stars in the local sky for variability. MASCARA has already discovered several planets in the northern sky, which are among the brightest known transiting hot Jupiter systems.
Aims. In this paper, we aim to characterize a transiting planetary candidate in the southern skies found in the combined MASCARA and bRing data sets of HD 85628, an A7V star of V = 8.2 mag at a distance 172 pc, to establish its planetary nature.
Methods. The candidate was originally detected in data obtained jointly with the MASCARA and bRing instruments using a Box Least-Square search for transit events. Further photometry was taken by the 0.7 m Chilean-Hungarian Automated Telescope (CHAT), and radial velocity measurements with the Fiber Dual Echelle Optical Spectrograph on the European Southern Observatory 1.0 m Telescope. High-resolution spectra during a transit were taken with the CTIO high-resolution spectrometer (CHIRON) on the Small and Moderate Aperture Research Telescope System 1.5 m telescope to target the Doppler shadow of the candidate.
Results. We confirm the existence of a hot Jupiter transiting the bright A7V star HD 85628, which we co-designate as MASCARA-4b and bRing-1b. It is in an orbit of 2.824 days, with an estimated planet radius of 1.53−0.04+0.07 RJup and an estimated planet mass of 3.1 ± 0.9 MJup, putting it well within the planetary regime. The CHAT observations show a partial transit, reducing the probability that the transit was around a faint background star. The CHIRON observations show a clear Doppler shadow, implying that the transiting object is in a retrograde orbit with |λ| =244.9−3.6+2.7°. The planet orbits at a distance of 0.047 ± 0.004 AU from the star and has a zero-albedo equilibrium temperature of 2100 ± 100 K. In addition, we find that HD 85628 has a previously unreported stellar companion star in the Gaia DR2 data demonstrating common proper motion and parallax at 4.3′′ separation (projected separation ~740 AU), and with absolute magnitude consistent with being a K/M dwarf.
Conclusions. MASCARA-4 b/bRing-1 b is the brightest transiting hot Jupiter known to date in a retrograde orbit. It further confirms that planets in near-polar and retrograde orbits are more common around early-type stars. Due to its high apparent brightness and short orbital period, the system is particularly well suited for further atmospheric characterization.
CLASH-VLT: Enhancement of (O/H) in z  =  0.35 RX J2248−4431 cluster galaxies
Authors: Ciocan B. I. , Maier C. , Ziegler B. L. , Verdugo M. 
Published: December 2019

Aims. Gas-phase metallicities offer insight into the chemical evolution of galaxies as they reflect the recycling of gas through star formation and galactic inflows and outflows. Environmental effects such as star-formation quenching mechanisms play an important role in shaping the evolution of galaxies. Clusters of galaxies at z <  0.5 are expected to be the sites where environmental effects can be clearly observed with present-day telescopes.
Methods. We explored the Frontier Fields cluster RX J2248−443 at z = 0.348 with VIMOS/VLT spectroscopy from CLASH-VLT, which covers a central region corresponding to almost 2 virial radii. The fluxes of [OII] λ3727, Hβ, [OIII] λ5007, Hα and [NII] λ6584 emission lines were measured allowing the derivation of (O/H) gas metallicities, star formation rates based on extinction-corrected Hα fluxes, and contamination from active galactic nuclei. We compared our sample of cluster galaxies to a population of field galaxies at similar redshifts.
Results. We use the location of galaxies in projected phase-space to distinguish between cluster and field galaxies. Both populations follow the star-forming sequence in the diagnostic diagrams, which allow the ionising sources in a galaxy to be disentangled, with only a low number of galaxies classified as Seyfert II. Both field and cluster galaxies follow the “main sequence” of star-forming galaxies, with no substantial difference observed between the two populations. In the mass–metallicity (MZ) plane, both high-mass field and cluster galaxies show comparable (O/H)s to the local SDSS MZ relation, with an offset of low-mass galaxies (log(M/M⊙) < 9.2) towards higher metallicities. While both the metallicities of “accreted” (R <  R500) and “infalling” (R >  R500) cluster members are comparable at all masses, the cluster galaxies from the “mass complete” bin (which is the intermediate mass bin in this study: 9.2 <  log(M/M⊙) < 10.2), show more enhanced metallicities than their field counterparts by a factor of 0.065 dex with a ∼1.8σ significance. The intermediate-mass field galaxies are in accordance with the expected (O/H)s from the fundamental metallicity relation, while the cluster members deviate strongly from the model predictions, namely by a factor of ∼0.12 dex. The results of this work are in accordance with studies of other clusters at z <  0.5 and favour the scenario in which the hot halo gas of low- and intermediate-mass cluster galaxies is removed due to ram pressure stripping, leading to an increase in their gas-phase metallicity.
Der Primär Obstruktive Megaureter (POM) – Eine Domäne konservativer Therapie
Authors: Stehr Maximilian , Schäfer Frank-Mattias 
Published: December 2019

ZusammenfassungDer Begriff „Megaureter“ ist eine rein deskriptive Bezeichnung einer Reihe von Krankheitsentitäten. Entscheidend ist, ob der Megaureter primär oder sekundär auftritt oder ob er obstruktiv und/oder refluxiv ist. Häufig liegt eine primäre Obstruktion im Bereich des ureterovesikalen Übergangs vor. Die Therapie des primär obstruktiven Megaureters hat sich in den letzten 30 Jahren deutlich gewandelt. Wurde früher in der Mehrzahl der Fälle eine Ureterreimplantation durchgeführt, werden heute 85 – 90 % der Patienten konservativ behandelt. Neben der Reimplantation steht mit der Ballondilatation ein modernes, minimal-invasives Verfahren zur Verfügung, das ist ausgewählten Fällen zu einem Benefit für den Patienten führen kann. Da es aufgrund der Möglichkeit eines postoperativ auftretenden VUR gleichwohl nicht komplikationslos ist, muss betont werden, dass die Verfügbarkeit dieses neuen Verfahrens die generell strenge Indikation zur Operation des Pirimär Obstruktiven Megaureters nicht aufweichen sollte.
Bilaterale Enukleation bei Hunden
Authors: Betz Daniela Simon 
Published: December 2019

Hamzianpour N, Smith K, Dawson C et al. Bilateral enucleation in dogs: A review of owner perceptions and satisfaction.
Vet Ophthalmol 2019; 22: 566–576
Die Enukleation ist eine häufige chirurgische Maßnahme bei irreversibel blinden, schmerzhaften Bulbi. Eine
beidseitige Enukleation kann als letzte Vorgehensweise bei primärem oder sekundärem therapieresistentem Glaukom in
Betracht gezogen werden und bei weiteren Ursachen irreversibler Schmerzzustände am Auge wie Trauma oder
Korneaperforation indiziert sein. Untersuchungen zur Zufriedenheit von Hundebesitzern, bei deren Hunden eine
beidseitige Enukleation erfolgte, liegen derzeit nicht vor. Ziel dieser Studie war daher, die Zufriedenheit der
Besitzer solcher Hunde sowie deren Perzeption bezüglich postoperativer Anpassung und Lebensqualität ihrer Tiere zu
evaluieren.
Übersicht zu Zusammenhängen zwischen Änderungen der Bewegungsintensität und Ketose bei
Milchkühen
Authors: Hajek Franziska , Mansfeld Rolf 
Published: December 2019

ZusammenfassungMit einer Prävalenz von bis zu 43 % zählt die subklinische Ketose zu den häufigsten Erkrankungen von Milchkühen in der
Transitphase. Sie kann ihrerseits Auslöser für Folgeerkrankungen wie klinische Ketose oder Lahmheit sein. Eine
Überwachung der Tiere in dieser Phase ist sehr wichtig. Hierzu eignen sich außer der Bestimmung von β-Hydroxybutyrat
bzw. Actetoacetat in Blut, Milch und Harn sowie der Beobachtung der Tiere auch computergestützte Systeme. Dafür werden
Daten, wie die Tieridentifikation und Aktivitätsdaten, auf einem Datenlogger aufgezeichnet und gespeichert und an einen
Computer übermittelt. Eine Änderung der Aktivität kann schon Tage vor dem Auftreten anderer Symptome ein Hinweis auf
eine zugrundeliegende Krankheit sein. Im Zusammenhang mit Ketose lässt sich schon 5 Tage vor der klinischen Diagnose
eine Aktivitätsabnahme beobachten. So leisten diese Daten einen wertvollen Beitrag für Landwirt und Tierarzt zur
Überwachung des Gesundheitszustands der Herde. Auch für die Erkennung einer beginnenden Lahmheit kann die
Aktivitätsmessung eingesetzt werden. Bei vorliegender Lahmheit nimmt die Bewegungsaktivität ab und die Liegeperioden
werden länger. Die Aktivitätsmessung über den Transponder gibt im Rahmen eines Herdenmonitorings wichtige Hinweise auf
die Lahmheitsprävalenz in einer Herde. Zusätzlich zur Aktivitätsmessung sollte eine visuelle Beurteilung durchgeführt
werden. Hierzu wurden Lahmheitsscores (Locomotion Score, Gait Score) entwickelt, anhand derer der Lahmheitsstatus der
Herde erhoben werden kann. Damit lassen sich die Tiere in Lahmheitsklassen einteilen und dadurch werden die Tiere
erkannt, die einer Klauenpflege oder Behandlung unterzogen werden sollten, um Folgeerkrankungen zu reduzieren oder zu
vermeiden. Plausibel ist, dass die Tiere aufgrund der Lahmheit, der damit einhergehenden reduzierten Aktivität und der
daraus folgenden verminderten Futteraufnahme eine subklinische oder klinische Ketose entwickeln. Sowohl aus Sicht der
Tiergesundheit als auch aus wirtschaftlichen Gründen ist eine frühzeitige Krankheitserkennung und -prophylaxe
wünschenswert und sollte deshalb Ziel eines Herdenmonitorings sein.
Management Driven Structured Reporting in Ovarian Cancer
Authors: Chandramohan Anuradha , Panda Sourav , Thomas Anitha , Chandy Rachel , Joel Anjana , Ram Thomas Samuel , Peedicayil Abraham 
Published: December 2019

AbstractSince majority (80%) of ovarian cancer patients present at an advanced stage, imaging performed on these patients have numerous findings. The combination of multiple findings on imaging, complexity of anatomical structures which are involved in ovarian cancer, and the need to perceive certain subtle imaging features which would impact management often makes it challenging to systematically review images of these patients. Similarly, it is difficult to effectively communicate these findings in radiology reports. Structured reporting that is geared toward clinical decision-making has been an area of recognized need. An understanding of the review areas, which aid clinical decision-making in a multidisciplinary team setting at our institution led us to the proposed structured reporting template for ovarian cancer. Through this review, the authors would like to share this reporting template with examples.
Spontaneous Epidural Hematoma of the Cervical Spine Following Thrombolysis in a Patient with STEMI—Two Medical Specialties Facing a Rare Dilemma
Authors: Tsarouchas Anastasios , Mouselimis Dimitrios , Bakogiannis Constantinos , Gkasdaris Grigorios , Dimitriadis George , Zioutas Dimitrios , Papadopoulos Christodoulos E. 
Published: December 2019

Abstract
Spontaneous spinal epidural hematoma (SSEH) is a rare, albeit well-documented complication following thrombolysis treatment in ST elevation myocardial infarction (STEMI). A SSEH usually manifests with cervical pain and neurologic deficits and may require surgical intervention. In this case report, we present the first reported SSEH to occur following thrombolysis with reteplase. In this case, the SSEH manifested with cervical pain shortly after the patient emerged from his rescue percutaneous coronary intervention (PCI). Although magnetic resonance imaging reported spinal cord compression, the lack of neurologic symptoms prompted the treating clinicians to delay surgery. A dangerous dilemma emerged, as the usual antithrombotic regimen that was necessary to avoid stent thrombosis post-PCI, was also likely to exacerbate the bleeding. As a compromise, the patient only received aspirin as a single antiplatelet therapy. Ultimately, the patient responded well to conservative treatment, with the hematoma stabilizing a week later, without residual neurologic deficits. In conclusion, the conservative treatment of SSEH appears to be an acceptable option for carefully selected patients, but the risks of permanent neurologic deficits and stent thrombosis have to be weighted for each patient.
Initial development of the digital crowd mapping for landslide monitoring and early warning system
Authors: Setiawan H , Wilopo W , Fathani T F , Andayani B , Karnawati D 
Published: December 2019

AbstractLandslide disaster risk reduction emphasizing community participation and technical instruments for monitoring and early warning has been introduced in Indonesia for more than a decade. Notable recognition from the international scientific community indicated that this approach is reliable and effective for landslide vulnerable area where a dense population exists. This paper presents our progress of the initial development framework of interdisciplinary product through digital crowd mapping for landslide and early warning in mobile apps. The crowd information from local people or community in the real-time as a ‘human sensor’ is the necessary and main point in developing this crowd mapping because not all of the landslide vulnerable area in Indonesia is covered by the monitoring and early warning technical instruments. Rainfall condition, threshold condition based on the geological structure, data monitoring from field early warning instruments, and verified crowd information from local people, are occupied as the ‘requirement definition’ for ‘system and software design’ that will be structured and provided in the apps. Central Java Province is selected as a pilot area in developing this digital crowd mapping.
Comparison study of beach geometrics and beach sand gradation related to abrasion potential based along the West Sumatra Province
Authors: Putra Y , Hakam A , Istijono B , Junaidi  , Adji B M 
Published: December 2019

Abstract
The West Sumatra beach is very beautiful and has much diversity in terms of their natural properties. This paper elaborating the diversity of the West Sumatra Beach related to their abrasion potential. Field investigation conducted to collect the nature diversities such as the plantation, sands and the geometric. The sand samples have been taken from beaches and brought to the laboratory to investigate their physical properties. The geometric of the beaches were analysed to gain the specific parameter which are comparable each other. The special study on the role of vegetation on abrasion protection as well as numerical modelling of their mechanism also had been studied and reviewed in this study. Those diversities then are turned into the engineering parameter and linked each other to gain their relation to abrasion potential. This study than can redraw the relation between the physical soil properties as well as the beach geometric with the abrasion potential of the beaches. The plantations on the beaches also gave a good correlation to the abrasion problems. The study can give better understanding between the beach abrasion problems with their nature of geology and biology as well as human activities. This study then suggested that to protect the beach abrasion it is necessary to investigate many things including many fields such as engineering, coastal, geology, biology as well as social science.
Microwave-assisted conversion of agro-industrial copra residue oil to diesel engine compatible fatty acid methyl esters
Authors: Ilham Z , Hakimi M I , Mansor M R A , Goembira F 
Published: December 2019

Abstract
Due to the increasing concern towards fossil fuel reserve and its fluctuating price, many countries shifted towards producing biodiesel as an alternative green fuel. In this study, the main objective is to synthesis biodiesel from coconut copra, an agro-industrial residue, as potential feedstock using different transesterification techniques, namely stirring mechanical-assisted technique (SAT), ultrasonic-assisted technique (UAT), and microwave-assisted technique (MAT). The current study will show comparison between the biodiesel yields, fatty acid methyl ester (FAME) compositions and fuel properties of the transesterification techniques used. The result showed that the copra residue biodiesel (CRB) using SAT produced the highest yield of biodiesel compared to UAT and MAT, which are 96.85% (±0.69), 93.79% (±1.00), and 91.76% (±0.87), respectively. Furthermore, different volumes of solvent and catalyst amount were found to affect the biodiesel yields, relatively. On the other hand, for FAME compositions, insignificant results were observed. The fuel properties in CRB complied with the international standards, thus, showing high compatibility to be used in diesel engine.