bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wingless ligands and beta‐catenin expression in the rat endometrium: The role of Wnt3 and Wnt7a/beta‐catenin pathway at the embryo–uterine interface
Authors: Kaloğlu Celal , Bulut Hüseyin E. , Hamutoğlu Rasim , Korkmaz Ertan M. , Önder Ozan , Dağdeviren Tuğba , Aydemir Merve N. 
Published: September 2020

AbstractWnt/beta‐catenin signaling may play an essential role in endometrial decidualization, placentation, and the establishment of pregnancy. We investigate here the possible roles, immunolocalizations, and synthesis of the Wnt3, Wnt7a, and beta‐catenin proteins in the rat endometrium during the estrous cycle and early postimplantation period. Wnt3 and Wnt7a had a similar localization and dynamic expression relative to the endometrial stages. Wnt7a immunostaining was not limited only to the luminal epithelial cells, but also to strong stainings in the stromal and endothelial cells. Wnt3, Wnt7a, and beta‐catenin were highly synthesized and colocalized at the trophoblast‐decidual interface; and were more obvious in the primary decidual zone, the GTCs, and the ectoplacental cone. Beta‐catenin was strongly localized at the borders of the mature decidual cells; however, Wnt3 and Wnt7a immunolocalizations were decreased in those cells. As such, the immunolocalization of Wnt3, Wnt7a, and beta‐catenin shifted with decidualization and placentation. The expression level of Wnt3, Wnt7a, and beta‐catenin messenger RNAs increased in early pregnancy, and especially between Days 8.5 and 9.5. The dramatic changes in the expression of Wnt3, Wnt7a, and beta‐catenin observed during the early days of pregnancy and the estrous cycle may indicate their roles in decidualization, stromal cell proliferation, and trophoblast invasion.
A DISPLAY WEEK LIKE NO OTHER
Authors: Atwood Stephen P. 
Published: September 2020

AbstractWhen I heard Display Week 2020 was being turned into an online event, I didn't know what to think. Of course, I had high expectations—anything put together by the Display Week Program Committee and supported by the team at PCM was going to be great. Still, I had never experienced a virtual conference before and had some concerns about how it would all come together. I'm sure I wasn't alone. Thankfully, when the first day came and we all signed in, the results were impressive. The format was intuitive, and the technical quality of the presentations was quite nice. There were some hiccups, as we've all come to expect from this new platform of video conferencing. But foremost, all the great content and events that were promised were there to enjoy.
Evaluating Display Color Capability
Authors: Smith Euan , Heckaman Rodney L. , Lang Karl , Penczek John , Bergquist Johan 
Published: September 2020

AbstractAlthough the CIE recommends using the 3D CIELAB color space to assess displays, a 3D CIELAB gamut plot can be difficult to calculate, render, and interpret. Here, a team of experts demonstrates why the gamut rings plot may be a better alternative.
Comparative In Vitro and In Vivo Effects of Feed Additives on Rainbow Trout Response to Ichthyophthirius multifiliis
Authors: Mathiessen Heidi , Jaafar Rzgar Mohammad , Al-Jubury Azmi , Gersdorff Jørgensen Louise , Kania Per Walter , Buchmann Kurt 
Published: September 2020

Abstract
Control of the skin parasitic ciliate Ichthyophthirius multifiliis is currently based on laborious chemical and mechanical approaches, thus advocating for alternative control measures. Here, we show that the early development of trophonts (feeding stage residing in the epidermis) in the Rainbow Trout Oncorhynchus mykiss epidermis was inhibited at 5 d postinfection after the administration of feed additives, including garlic Allium sativum, oregano Origanum onites, thyme Thymus vulgaris, coriander Coriandrum sativum, and astaxanthin (a carotenoid derived from the alga Haematococcus pluvialis). However, no inhibition was observed at 8 d postinfection. We investigated whether the early inhibition was caused by (1) the feed additives’ direct effect on the parasite and/or (2) stimulation of the Rainbow Trout immune responses. Garlic exhibited the highest in vitro killing capacity toward theronts (the infective stage of the parasite), followed by oregano, thyme, and astaxanthin, whereas coriander had no in vitro parasiticidal effect. Immune reactions were measured by plasma lysozyme activity in Rainbow Trout after feeding and by recording immune gene expression in trout leukocytes that were exposed to feed additives. Oregano-fed fish showed a significantly (P &lt; 0.05) elevated plasma lysozyme activity. Oregano and thyme—and to a lesser extent, garlic, astaxanthin, and coriander—induced a significant regulation of innate and adaptive immune genes in vitro. The results suggest that the investigated additives inhibit early parasite development directly as well as indirectly (i.e., by elevating the host immune response).
Treatment of urethral stricture disease in women: A multi‐institutional collaborative project from the SUFU research network
Authors: Lane Giulia I. , Smith Ariana L. , Stambakio Hanna , Lin George , Al Hussein Alawamlh Omar , Anger Jennifer T. , Brandes Eileen R. , Carmel Maude E. , Chung Doreen E. , Cox Lindsey , DeLong Jessica , Elliott Christopher S. , Eltahawy Ehab , Aparecido França Wagner , Gousse Angelo , Gupta Priyanka , Hagedorn Judith C. , High Rachel A. , Khan Aqsa , Kowalik Casey , Lee Richard K. , Lee Una J. , Lucioni Alvaro , MacDonald Susan , Malaeb Bahaa , McKay Scotty , Padmanabhan Priya , Powell Charles R. , Sajadi Kamran P. , Sutherland Suzette E. , Theva Didi , Vollstedt Annah , Welk Blayne , Zheng Yu , Cameron Anne P. ,   for the Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Research Network (SURN)
Published: September 2020

AbstractAimFemale urethral stricture disease is rare and has several surgical approaches including endoscopic dilations (ENDO), urethroplasty with local vaginal tissue flap (ULT) or urethroplasty with free graft (UFG). This study aims to describe the contemporary management of female urethral stricture disease and to evaluate the outcomes of these three surgical approaches.MethodsThis is a multi‐institutional, retrospective cohort study evaluating operative treatment for female urethral stricture. Surgeries were grouped into three categories: ENDO, ULT, and UFG. Time from surgery to stricture recurrence by surgery type was analyzed using a Kaplan–Meier time to event analysis. To adjust for confounders, a Cox proportional hazard model was fit for time to stricture recurrence.ResultsTwo‐hundred and ten patients met the inclusion criteria across 23 sites. Overall, 64% (n = 115/180) of women remained recurrence free at median follow‐up of 14.6 months (IQR, 3–37). In unadjusted analysis, recurrence‐free rates differed between surgery categories with 68% ENDO, 77% UFG and 83% ULT patients being recurrence free at 12 months. In the Cox model, recurrence rates also differed between surgery categories; women undergoing ULT and UFG having had 66% and 49% less risk of recurrence, respectively, compared to those undergoing ENDO. When comparing ULT to UFG directly, there was no significant difference of recurrence.ConclusionThis retrospective multi‐institutional study of female urethral stricture demonstrates that patients undergoing endoscopic management have a higher risk of recurrence compared to those undergoing either urethroplasty with local flap or free graft.
Qualitative research on end‐of‐life communication with family carers in nursing homes: A discussion of methodological issues and challenges
Authors: Gonella Silvia , Di Giulio Paola , Palese Alvisa , Dimonte Valerio , Campagna Sara 
Published: September 2020

AbstractAimTo identify and summarize the challenges of conducting qualitative research exploring end‐of‐life communication between healthcare providers and bereaved family carers in nursing homes.DesignA descriptive qualitative study based on in‐the‐field‐notes and research diaries collected during a primary study involving 32 bereaved family carers and 14 nurses across 13 Italian nursing homes in 2018–2019.MethodsTwo trained female nurses conducted semi‐structured, in‐depth, open‐ended interviews and recorded “in action” (i.e. reflections reported as in‐the‐field‐notes) and “on action” (i.e. retrospective reflections within the team reported immediately in the research diaries) narratives, with the aim of identifying challenges encountered during the research process. A content analysis process was performed to analyse the narratives collected.ResultsWe identified three major categories of challenges: (a) obtaining approval from the ethical committee; (b) approaching nursing homes and family carers; and (c) dealing with participant‐related impairments (i.e. memory, emotional, physical).
Fishbone artefacts from the Samrong Sen site, Cambodia, cast new light on Bronze Age networking between inland and coastal communities
Authors: Boulanger Clara , Puaud Simon , Ly Vanna , Glémarec Laurence , Heng Sophady , Forestier Hubert 
Published: September 2020

AbstractIn this paper, we examine previously unstudied archaeological fish remains recovered during Mansuy's first excavation in 1902 from the inland Samrong Sen midden site in Cambodia and which are currently stored at the Musée de l'Homme, Paris, France. The remains are dated by association to the Neolithic/Bronze Age between 2206 and 1892 cal. bc from a time when the development of metal age trade and exchange networks contributed substantially to the success of many cultures in this diverse region. We focus on the taxonomy of the fish captured and the implications for technology and regional networks. The identification of two perforated shark vertebrae beads indicates that, during the late Neolithic to Bronze Age period, trade and exchange between coastal and inland communities was prominent on mainland Southeast Asia.
Attrition of Patients on a Precision Oncology Trial: Analysis of the I-PREDICT Experience
Authors: Bohan Sandy S. , Sicklick Jason K. , Kato Shumei , Okamura Ryosuke , Miller Vincent A. , Leyland-Jones Brian , Lippman Scott M. , Kurzrock Razelle 
Published: September 2020

Abstract

Background
Precision oncology uses molecular profiling of tumors to identify biomarker-tailored therapies for patients in the hope of improving outcomes. Typically, only a minority of patients receives evaluable matched treatment. This study explored the reasons for attrition on a precision medicine trial.

Materials and Methods
Study participants were 190 adult patients who consented to the I-PREDICT (Investigation of molecular Profile-Related Evidence Determining Individualized Cancer Therapy) trial. Patients had metastatic and/or unresectable incurable malignancies. Patients who were not evaluable were analyzed.

Results
Of consented patients, 44% were not evaluable. Men were twice as likely to be not evaluable as women. Prominently, 45% of patients who were not evaluable dropped off because of death, hospice referral, or decline in organ function.

Conclusion
Health deterioration of consented patients is a significant barrier to being evaluable on the I-PREDICT trial. These data suggest that patients are enrolled on precision oncology trials too late in their disease course or with excessive disease burden.
Effects of toughened polyester on fatigue behavior of glass fiber reinforced polyester composite for wind turbine blade
Authors: Mousavi Khorasani Mohammad Amin , sahebian samaneh , Zabett Ahad 
Published: September 2020

AbstractCured unsaturated polyester resins are often highly brittle. In this paper, to improve fatigue life of the glass fiber‐reinforced polyester composite (GFRP) used in the wind turbine blade, the unsaturated polyester resin was toughened by 2 wt% liquid carboxyl‐terminated butadiene acrylonitrile (CTBN) copolymer. CTBN liquid rubber has acidic OH of the carboxylic group, which causes incompatibility and poor solubility of CTBN in unsaturated polyester resins. In this study, to increase compatibility and solubility of CTBN liquid rubber in unsaturated polyester resins, 1,4‐Butanediol diglycidyl ether (1,4‐BDGE) was selected to react with carboxylic group of the CTBN liquid rubber which converted to ester functional group. The reactions between epoxy groups of 1,4‐BDGE and carboxyl groups of CTBN were investigated by Fourier‐transform infrared (FTIR) spectroscopy. Four polyester samples were prepared by mixing unsaturated polyester with 0 to 3 wt% of modified CTBN. Tensile tests of polymer samples have been performed to observe the effect of modified CTBN additive. According to the results of the tensile test, the highest tensile strength, elongation‐at‐break, and modulus of toughness were observed in polyester with 2 wt% rubber. Two polyester/glass fiber composite samples with and without 2 wt% rubber were prepared by the vacuum infusion process (VIP) and subjected to fatigue behavior analysis. According to the results of the static tension test, the same value of tensile strength was observed in both composites. The obtained tension‐tension fatigue results (R = 0.1) showed a reduction in maximum stress level enhanced the fatigue life improvement for the samples with 2 wt% rubber due to the increased toughness of the composite matrix. Examining the fracture surfaces of the specimens after fatigue tests, it was revealed that failure of the polyester containing 2 wt% rubber/glass fiber occurred at the interface, while the specimens without rubber showed that failure did not occur at the fiber/matrix interface.
Covalent Modification of Proteins by Plant‐Derived Natural Products: Proteomic Approaches and Biological Impacts
Authors: Tocmo Restituto , Veenstra Jacob P. , Huang Yunying , Johnson Jeremy James 
Published: September 2020

AbstractPlant‐derived natural products (NPs) with electrophilic functional groups engage various subsets of the proteome via covalent modification of nucleophilic cysteine residues. This electrophile‐nucleophile interaction can change protein conformation, alter protein function, and modulate their biological action. The biological significance of these covalent protein modifications in health and disease is increasingly recognized. One way to understand covalent NP‐protein interactions is to utilize traditional proteomics and modern mass spectrometry (MS)‐based proteomic strategies. These strategies have proven effective in uncovering specific NP protein targets and are critical first steps that allow for a much deeper understanding of the ability of NPs to modulate cellular processes. Here, plant‐derived NPs that covalently modify proteins are reviewed, the biological significance of these covalent modifications, and the different proteomic strategies that have been employed to study these NP‐protein interactions.
Home nursing for children with home mechanical ventilation in the United States: Key informant perspectives
Authors: Sobotka Sarah A. , Dholakia Ayesha , Berry Jay G. , Brenner Maria , Graham Robert J. , Goodman Denise M. , Agrawal Rishi K. 
Published: September 2020

AbstractObjectives & HypothesisChildren with home mechanical ventilation (HMV) require skilled care by trained caregivers, and their families feel the impacts of ubiquitous home nursing shortages. It is unknown which factors determine allocation; no standards for private duty nursing intensity exist. We sought to characterize provider experiences with and opinions on home nursing for children with HMV, hypothesizing providers would describe frequent home nursing gaps across clinical scenarios.MethodsPurposeful and snowball sampling identified key informant clinical providers. Survey topics included hours of home nursing received across clinical and family scenarios. Close‐ended responses were analyzed using descriptive statistics and open‐ended questions coded with iterative modification for major theme agreement.ResultsA total of 59 respondents represented care of patients from 44 states; 49.2% physicians, 37.3% nurses, 10.2% respiratory therapists, and 3.4% case managers. Nearly all (97%) believed that families should receive more hours during initial home transition, yet less than half (47%) do. The majority (80.7%) thought the presence of other children in the home should influence nursing hours, yet only three (5.3%) reported other children have influence. Across hypothetical medical technology scenarios, providers consistently described children receiving fewer nursing hours than the providers' ideal practice. A third (31.7%) described discharging patients without any home nursing arranged.ConclusionsThis HMV provider sample highlights pervasive deficiency in home nursing provision with heterogenous interpretation of what constitutes ideal home care. Family and social contextual factors are infrequently considered in nursing allocations. Provider, community health, and family stakeholders must collaborate to generate national community practice standards for children with HMV.
An interactive teaching module for increasing undergraduate physiotherapy students' cultural competence: A quantitative survey
Authors: Fryer Caroline , Edney Sarah , van Kessel Gisela 
Published: September 2020

AbstractObjectivesTo provide safe and effective healthcare, physiotherapists must be aware of, and able to appropriately respond to, the individual needs of their clients. Cultural competence is an essential part of the curriculum to prepare physiotherapy students for their graduate practice. The primary aim of this study was to investigate the effectiveness of a 4‐week educational intervention to increase the perceived cultural competence of undergraduate physiotherapy students and whether effectiveness changed as students progressed in their education. Secondary aims were to understand if a clinical placement prior to the course intervention, or the student's cultural background, influenced the effectiveness of the intervention.MethodsA prospective cohort study was conducted with 73 students in their second year of an Australian Bachelor of Physiotherapy programme who participated in a 4‐week tutorial module to develop their cultural competence. Perception of cultural competence was measured at three time points (pre, post, post 18 months) using the Cultural Intelligence Scale questionnaire which assesses metacognitive, cognitive, motivational and behavioural domains. Participant and their parents' country of birth data were collected.ResultsCultural intelligence scores for the cohort significantly increased from pre‐ to post‐intervention (mean change 0.4, p < 0.001). A 3‐week clinical placement prior to the teaching intervention had no effect on the change in scores. Students who were not born in Australia, or who had a parent not born in Australia, demonstrated less change in overall cultural intelligence score than Australian‐born participants.ConclusionUndergraduate physiotherapy students at an Australian university can increase their perceived level of cultural competence by participating in a 4‐week classroom‐based tutorial module, and this effect can be sustained over an 18‐month period. Exposure to cultural diversity is not sufficient by itself for a change in perceived cultural competence. However, classroom‐based teaching needs to be responsive to the cultural characteristics of the students.
Solution NMR structure of Se0862, a highly conserved cyanobacterial protein involved in biofilm formation
Authors: Zhang Ning , Chang Yong‐Gang , Tseng Roger , Ovchinnikov Sergey , Schwarz Rakefet , LiWang Andy 
Published: September 2020

AbstractBiofilms are accumulations of microorganisms embedded in extracellular matrices that protect against external factors and stressful environments. Cyanobacterial biofilms are ubiquitous and have potential for treatment of wastewater and sustainable production of biofuels. But the underlying mechanisms regulating cyanobacterial biofilm formation are unclear. Here, we report the solution NMR structure of a protein, Se0862, conserved across diverse cyanobacterial species and involved in regulation of biofilm formation in the cyanobacterium Synechococcus elongatus PCC 7942. Se0862 is a class α+β protein with ααββββαα topology and roll architecture, consisting of a four‐stranded β‐sheet that is flanked by four α‐helices on one side. Conserved surface residues constitute a hydrophobic pocket and charged regions that are likely also present in Se0862 orthologs.
Solution NMR structure of Borrelia burgdorferi outer surface lipoprotein BBP28, a member of the mlp protein family
Authors: Fridmanis Jēkabs , Otikovs Mārtiņš , Brangulis Kalvis , Tārs Kaspars , Jaudzems Kristaps 
Published: September 2020

AbstractLyme disease is the most widespread vector‐transmitted disease in North America and Europe, caused by infection with Borrelia burgdorferi sensu lato complex spirochetes. We report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBP28, a member of the multicopy lipoprotein (mlp) family. The structure comprises a tether peptide, five α‐helices and an extended C‐terminal loop. The fold is similar to that of Borrelia turicatae outer surface protein BTA121, which is known to bind lipids. These results contribute to the understanding of Lyme disease pathogenesis by revealing the molecular structure of a protein from the widely found mlp family.
Insights to the Columbia Gas Explosions Lawrence and North Andover, MA September 13, 2018
Authors: Willey Ronald J. 
Published: September 2020

AbstractOn September 13, 2018 at approximately 4:00 pm EDT a series of emergency calls were received by 911 operators working the Lawrence and North Andover region of Massachusetts. The calls ranged from smells of “natural gas” to actual fires to actual explosions (at least five recorded). A low‐pressure natural gas supply system (0.5 psig 14 in. water column) “overpressurized” by at least one order of magnitude. Approximately 8600 customers were affected. Of these, 131 customers had some type of “extended over pressure event” such as a release of natural gas within their basement. This is a 1.5% failure rate on systems that should have been in place when over pressure occur. Unfortunately, this 1.5% failure rate translated into a multimillion dollar loss for the gas company, and the disruption of quality of life for 8600 residents, hundreds of whom were displaced for over 6 months as their homes were rebuilt. One year later, full recovery is still in progress for the area. The root cause traces back to a failed “management of change” system. With proper a hazard analysis/safety review and communication, this event could have been prevented or at least mitigated.