bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure Doses to Technologists Working in 7 PET/CT Departments
Authors: Li Weiguo , Fang Lianying , Li Jieqing 
Published: July 2020

Objective: The aim of this study was to measure occupational exposure doses of technologists who dispense and inject radiopharmaceuticals in 7 positron emission tomography/computed tomography (PET/CT) departments. This was done with the goal to help improving protective designs in PET departments and/or establishing national protection standards. Method: Common LiF thermoluminescence dosimeters (TLDs) were placed on the chest and necklace of the technologists to monitor whole-body and thyroid doses, respectively. Ring TLDs were also worn on both index fingers to measure individual hand doses. All TLDs were assembled and measured once every 3 months for a total of 12 months. Additionally, we measured and compared the dose of TLDs attached to both the inside and the outside of the technologist’s lead coat. Results: Technologists received relatively high exposures, which accounted for 64% to 94% of the collective dose in their respective departments. Their thyroid doses ranged from 1.2 to 1.7 mSv/a; some technologists’ hand doses exceeded 500 mSv/a. Use of a lead coat reduced the average dose by 8%. Conclusion: Technologists working in PET/CT departments were the main population exposed to radiation. This work underscores the need for enhanced protective measures for these workers to better reduce their exposure, particularly for their hands.
Cryptochrome 1 Alleviates the Antiproliferative Effect of Isoproterenol on Human Gastric Cancer Cells
Authors: Huang Qianwu , Lv Jun , Dong Ting , Liu Haijun , Xu Lei , Wu Mingcai 
Published: July 2020

Background: Cryptochrome 1 (CRY1) is a key protein that regulates the feedback loop of circadian clock. The abnormal expression of CRY1 was reported in numerous cancers, and contributed to tumorigenesis and progression. But the underlying mechanism remains undefined. Methods: CRY1 overexpression was constructed by lentivirus vector. Gene and protein expression was detected by reverse transcription quantitative polymerase chain reaction and Western blot. Cell proliferation was analyzed by CCK-8 assay. Cell migration ability was analyzed by scratch assay and transwell migration assay. The cAMP concentration was measured by intracellular cAMP assay. Results: Overexpression of CRY1 showed slightly effect on the proliferation and migration of HGC-27 cells. Upon exposure to isoproterenol (ISO), a β-adrenergic receptor agonist, cell proliferation, and migration were inhibited while the cAMP/PKA pathway was activated and ERK1/2 phosphorylation was suppressed. CRY1 overexpression reduced cAMP accumulation, retained ERK1/2 phosphorylation level and alleviated the antiproliferative effect upon exposure to ISO. However, CRY1 overexpression was inoperative on the antiproliferative effect of forskolin (FSK), a direct activator of adenyl cyclase (AC), or 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase (PDE) inhibitor. Conclusions: Our results suggest CRY1 overexpression may protect cells from the antiproliferative effects via activation of the cAMP/PKA pathway through interrupting signal transduction from G protein-coupled receptors to AC.
Initial experience with the novel p64MW HPC flow diverter from a cohort study in unruptured anterior circulation aneurysms under dual antiplatelet medication
Authors: Petrov Andrey , Rentsenkhuu Ganbaatar , Nota Baatarjan , Ganzorig Erdenebat , Regzengombo Boldbat , Jagusch Sara , Henkes Elina , Henkes Hans 
Published: July 2020

Objective p64MW HPC is a new low-profile flow diverter with reduced thrombogenicity due to hydrophilic coating. The purpose of this study was to evaluate its safety and efficacy in Mongolian patients under dual antiplatelet therapy. Methods Consecutive patients with unruptured anterior circulation aneurysms were prospectively enrolled. All patients received aspirin and clopidogrel before and six months after the procedure, followed by lifelong aspirin medication. High platelet reactivity (VerifyNow) did not trigger further action. The safety and efficacy endpoints were clinical outcome and aneurysm occlusion. Results In 29 patients (26 female, median age 57 years), 46 aneurysms (neck width 3.3 mm, fundus diameter 3.7 mm, median) were treated. Dual platelet function inhibition was confirmed in eight patients (28%). The response to Clopidogrel was between 100 and 239 P2Y12 reaction units (VerifyNow) in 13 patients (45%). Non-response to at least one drug was found in 8 of 29 patients (28%). One collapsed p64MW HPC required balloon angioplasty. No other periprocedural thrombus formation occurred. Postprocedural MRI revealed lesions with diffusion restriction in 3 of 29 patients. Digital subtraction angiography after three months for 42 of 46 (91%) aneurysms showed an adequate aneurysm occlusion in 25 (60%). Distal p64MW HPC migration of 3 implants was retreated with another p64MW HPC. Follow-up digital subtraction angiography of 26 of 46 (57%) aneurysms after six months showed adequate aneurysm occlusion in 22 (85%). Significant in-stent stenosis or thrombosis, morbidity or mortality was not encountered. Conclusion p64MW HPC implantation in patients under dual antiplatelet therapy with or without dual platelet function inhibition has a low procedural complication rate. The early aneurysm occlusion rate is high.
Therapeutic potential of pyruvate therapy for patients with mitochondrial diseases: a systematic review
Authors: Li Min , Zhou Shuang , Chen Chaoyang , Ma Lingyun , Luo Daohuang , Tian Xin , Dong Xiu , Zhou Ying , Yang Yanling , Cui Yimin 
Published: July 2020

Background: Mitochondrial disease is a term used to describe a set of heterogeneous genetic diseases caused by impaired structure or function of mitochondria. Pyruvate therapy for mitochondrial disease is promising from a clinical point of view. Methods: According to PRISMA guidelines, the following databases were searched to identify studies regarding pyruvate therapy for mitochondrial disease: PubMed, EMBASE, Cochrane Library, and Clinicaltrials. The search was up to April 2019. The endpoints were specific biomarkers (plasma level of lactate, plasma level of pyruvate, L/P ratio) and clinical rating scales [Japanese mitochondrial disease-rating scale (JMDRS), Newcastle Mitochondrial Disease Adult Scale (NMDAS), and others]. Two researchers independently screened articles, extracted data, and assessed the quality of the studies. Results: A total of six studies were included. Considerable differences were noted between studies in terms of study design, patient information, and outcome measures. The collected evidence may indicate an effective potential of pyruvate therapy on the improvement of mitochondrial disease. The majority of the common adverse events of pyruvate therapy were diarrhea and short irritation of the stomach. Conclusion: Pyruvate therapy with no serious adverse events may be a potential therapeutic candidate for patients with incurable mitochondrial diseases, such as Leigh syndrome. However, recent evidence taken from case series and case reports, and theoretical supports of basic research are not sufficient. The use of global registries to collect patient data and more adaptive trial designs with larger numbers of participants are necessary to clarify the efficacy of pyruvate therapy.
Psychosocial factors and medication adherence among recipients of vascularized composite allografts
Authors: Van Pilsum Rasmussen Sarah E , Ferzola Alexander , Cooney Carisa M , Shores Jaime T , Lee WP Andrew , Goldman Emily , Kaufman Christina L , Brandacher Gerald , Segev Dorry L , Henderson Macey L 
Published: July 2020

Objectives: Psychosocial factors are important predictors of medication adherence, and subsequently graft survival, in solid organ transplantation. Early experiences suggest this may also be the case in vascularized composite allotransplantation. Methods: Using validated tools, we surveyed upper extremity transplant recipients at two centers to assess depression (Patient Health Questionnaire-9), personality (Ten-Item Personality Inventory), anxiety (Generalized Anxiety Disorder 7-Item Scale), post-traumatic stress disorder (Primary Care Post-Traumatic Stress Disorder Screen for Diagnostic and Statistical Manual of Mental Disorders, 5th Edition), and social support (Multidimensional Scale of Perceived Social Support). Medication adherence among vascularized composite allotransplantation recipients at two centers was assessed by a member of the clinical research team using the recipients’ medical records. Results: Medication adherence was reported for 12 vascularized composite allotransplantation recipients, and 9 vascularized composite allotransplantation recipients completed psychosocial assessments. Most recipients were believed to be adherent to their immunosuppression, however, three recipients were believed to be non-adherent and a member of the clinical team had discussed non-adherence at least once with five recipients. Results from the psychosocial assessment (n = 9) indicated that eight participants had high levels of social support, and eight demonstrated high levels of conscientiousness which have been associated with better medication adherence in solid organ transplantation. However, three participants demonstrated mild anxiety, two demonstrated minimal symptoms of depression, and one demonstrated post-traumatic stress disorder which have been associated with worse medication adherence in solid organ transplantation. Conclusion: These findings lay the groundwork for future assessments of the role psychosocial factors play in facilitating medication adherence and broader transplant outcomes.
Phytochemical analysis and in vitro anti-proliferative activity of Viscum album ethanolic extracts
Authors: Holandino Carla , Melo Michelle Nonato de Oliveira , Oliveira Adriana Passos , Batista João Vitor da Costa , Capella Marcia Alves Marques , Garrett Rafael , Grazi Mirio , Ramm Hartmut , Torre Claudia Dalla , Schaller Gerhard , Urech Konrad , Weissenstein Ulrike , Baumgartner Stephan 
Published: July 2020

Abstract
Background
Viscum album L. (Santalaceae), commonly known as mistletoe, is a hemiparasitic plant traditionally used in complementary cancer treatment. Its antitumor potential is mostly attributed to the presence of aqueous soluble metabolites; however, the use of ethanol as solvent also permits the extraction of pharmacological compounds with antitumor potential. The clinical efficacy of mistletoe therapy inspired the present work, which focuses on ethanolic extracts (V. album “mother tinctures”, MT) prepared from different host trees.

Methods
Samples from three European subspecies (album, austriacum, and abietis) were harvested, and five different V. album-MT strains were prepared. The following phytochemical analyses were performed: thin layer chromatography (TLC), high-performance liquid chromatography (HPLC) and liquid chromatography-high resolution mass spectrometry (LC-HRMS). The proliferation assay was performed with WST-1 after incubation of tumor (Yoshida and Molt-4) and fibroblast cell lines (NIH/3 T3) with different MT concentrations (0.5 to 0.05% v/v). The cell death mechanism was investigated by flow cytometry (FACS) using Annexin V-7AAD.

Results
Chemical analyses of MT showed the presence of phenolic acids, flavonoids and lignans. The MT flavonoid and viscotoxin contents (mg/g fresh weight) were highest in Quercus robur (9.67 ± 0.85 mg/g) and Malus domestica (3.95 ± 0.58 mg/mg), respectively. The viscotoxin isoform proportions (% total) were also different among the VA subspecies with a higher content of A3 in V. album growing on Abies alba (60.57 ± 2.13). The phytochemical compounds as well as the viscotoxin contents are probably related to the antitumor effects of MT. The cell death mechanisms evaluated by colorimetric and FACS methodologies involved necrotic damage, which was host tree-, time- and dose- dependent, with different selectivity to tumor cells. Mother tincture from V. album ssp. abietis was the most effective at inducing in vitro cellular effects, even when incubated at the smallest concentration tested, probably because of the higher content of VT A3.

Conclusion
Our results indicate the promising antitumor potential of Viscum album ethanolic extracts and the importance of botanical and phytochemical characterization for in vitro anti-proliferative effects.
Prognostic value of routine blood tests along with clinical risk factors in predicting ischemic stroke in non-valvular atrial fibrillation: a prospective cohort study
Authors: Yang Seokhun , Cha Myung-Jin , Kwak Soongu , Kwon Soonil , Lee Seoyoung , Park Jiesuck , Choi You-jung , Moon Inki , Lee Euijae , Lee So-Ryoung , Choi Eue-Keun , Oh Seil 
Published: July 2020

Abstract
Background
In patients with atrial fibrillation (AF), most biomarkers are still of limited use due to cost-effectiveness and complexity in clinical practice.

Hypotheses
Biomarkers from routine blood tests improve the current risk stratification in AF patients.

Methods
This prospective study enrolled 600 patients diagnosed with non-valvular AF, of whom 537 were analyzed. Platelet count; platelet distribution width (PDW); red cell distribution width (RDW); and creatinine, D-dimer, and troponin I levels were measured at enrollment.

Results
During the mean follow-up period (2.2 ± 0.6 years), 1.9% patients developed ischemic stroke. According to the optimal cutoff of each biomarker, the risk of ischemic stroke was higher in patients with RDW ≥ 13.5%, creatinine ≥ 1.11 mg/dL, or PDW ≥ 13.2% (significant biomarkers; P value: < 0.01, 0.04, or 0.07, respectively). These 3 significant biomarkers had higher information gain than clinical risk factors in predicting ischemic stroke. The cumulative incidence of ischemic stroke was 1.2%, 1.1%, 8.4%, and 40.0% in patients with 0, 1, 2, and 3 significant biomarkers, respectively (P-for-trend < 0.001). Patients with  ≥ 2 significant biomarkers had a significantly higher risk of ischemic stroke than those with  < 2 significant biomarkers (adjusted hazard ratio 11.5, 95% confidence interval 3.3–40.2, P < 0.001). The predictability for ischemic stroke was significantly improved when  ≥ 2 significant biomarkers were added to the CHA2DS2–VASc score (area under the curve 0.790 vs. 0.620, P = 0.043).

Conclusion
Routine blood tests can provide better risk stratification of AF along with clinical risk factors.
Supplementary data on virus-like particles in the brainstem of Parkinson’s disease patients and controls
Authors: Dourmashkin Robert R. , Locker Peter , McCall Sherman A. , Hannah Matthew J. 
Published: July 2020

In this study, we present 84 transmission electron microscopy (TEM) images of human brainstem tissue from 11 cases of late onset Parkinson’s disease (PD). The tissues were fixed, embedded, sectioned, and stained for TEM application. In addition, we present 14 images from autopsy specimens of 1 case of human poliomyelitis infection as positive controls and 14 images from 8 cases of autopsy specimens of other conditions as negative controls. In the TEM images of the PD cases there were cytoplasmic inclusion bodies consisting of virus-like particles (VLP) 30 nm in diameter that were associated with endoplasmic reticulum membranes. In the nuclei of the PD neurons there were VLP ranging from 40 nm to 50 nm in diameter. In the poliomyelitis cases, similar particles as were observed in PD which were interpreted to be poliomyelitis virus particles. In the negative controls one case was identified which showed similar VLP (Figure 1, controls). A Lewy body was found in this “control” case (Figure 10) suggesting that this was an undiagnosed case of PD. Cytoplasmic ribosomes measuring approximately 17 nm were observed in the control neurons.
Myśl polityczna młodych polskich nacjonalistów w procesie przemian
Authors: Smolik Bartosz 
Published: July 2020

The Political Thought of Young Polish Nationalists in the Process of Change. Between the “Heritage” of National Democracy and the Necessity for Modernizing
The article aims to answer the question: what is the degree of advancement of the political thought of Polish nationalists? It refers to activists who admit to being ideologically related to the National Democracy (Narodowa Demokracja), i.e., a broad political movement that originated in 1893, and which has freely developed since the outbreak of the Second World War. Polish nationalists – continuing the historical national movement (Narodowa Demokracja) – must decide to what extent they wish to remain faithful to the more-than-a century‑old “heritage” of their predecessors, and to what extent they should eliminate the anachronisms incomprehensible to contemporary Poles and introduce new elements. To answer this question, the author examines the political writings of two leading centres of the political thought of Polish nationalists in the form of the periodicals Myśl.pl and Polityka Narodowa.
Modelo Pedagógico del Proceso Tutorial en la Formación Inicial del Maestro Primario para la Orientación a la Familia desde la Unidad Docente
Authors: Martínez Isaac Martha 
Published: July 2020

Este trabajo se realiza a partir de la observación de deficiencias en la práctica educativa diaria relacionada con el desarrollo del proceso tutoral en la escuela primaria en condiciones de Unidad Docente, específicamente para la orientación a la familia desde la formación inicial del maestro, aspecto que se corrobora a partir de diagnósticos realizados en la tutoría de diferentes tesis de maestría en la Universidad de Oriente de Santiago de Cuba, La constatación de las limitaciones, condujeron a la exploración de las investigaciones realizadas con relación a la tutoría en la formación inicial de los profesionales de la educación. En este sentido se advierten insuficiencias epistémicas relacionadas con la contextualización de la tutoría al proceso de orientación familiar lo cual incide negativamente en la calidad del proceso tutoral en la escuela primaria como Unidad Docente, siendo necesario perfeccionar este proceso desde una de las aristas más desfavorecida en relación con la función orientadora del docente, la orientación a la familia, por su incidencia imprescindible en la formación de la personalidad de acuerdo con las exigencias del modelo de escuela en Cuba, de aquí que se proponga como objetivo, la elaboración de un modelo pedagógico del proceso tutoral para la orientación a la familia desde la Unidad Docente.
La rÃ©gionalisation, nouveau mode de gouvernance du systÃ¨me de santÃ© : Ã©tat des lieux pour le cas du Maroc
Authors: Khider Abdelkader El , Imichoui Hanaa 
Published: July 2020

Lâ€™impÃ©ratif de lâ€™articulation des procÃ©dÃ©s du dÃ©veloppement humain nous mÃ¨ne Ã mettre en relief les diffÃ©rentes visions de la gouvernance de santÃ© au Maroc. La rÃ©gionalisation de la santÃ© constitue une opportunitÃ© pour le pays de promouvoir le dÃ©veloppement humain. Dans cet article, lâ€™intÃ©rÃªt sera portÃ© tout dâ€™abord sur la notion de la rÃ©gionalisation des systÃ¨mes de santÃ©. En se focalisant sur le cas marocain, il sâ€™agira de prÃ©senter ensuite lâ€™Ã©volution de ce processus ainsi quâ€™un bilan rÃ©gional en termes de performance sanitaire. Pour conclure, le papier sâ€™interroge sur les perspectives et les conditions nÃ©cessaires pour que ce mÃ©canisme de gouvernance puisse Ãªtre un levier de lâ€™amÃ©lioration de la santÃ© des populations dans les diffÃ©rentes rÃ©gions du pays.
The imperative of articulating human development processes leads us to highlight the different visions of health governance in Morocco. The regionalization of the Moroccan health system is an opportunity for the country to promote human development. In this article, interest will first be focused on the notion of regionalisation of health systems. Focusing on the Moroccan case, the evolution of this process is presented as well as a regional assessment in terms of health performance. To conclude, the paper questioned the necessary perspectives and conditions for this governance mechanism to be a lever for improving the health of populations in the different regions of the country.
Logique Communicationnelle, Posture et Division dans les Familles Ã‰largies: Cas de Baazra, en CÃ´te dâ€™Ivoire
Authors: Emmanuel Gala Bi TiziÃ© , Roland Bini Koff 
Published: July 2020

Cet article vise Ã comprendre la dynamique communicationnelle Ã Baazra, village de la commune de ZuÃ©noula, au centre-ouest de la CÃ´te dâ€™Ivoire, ses causes et consÃ©quences. Il sâ€™agit dâ€™une Ã©tude qualitative qui sâ€™appuie sur une mÃ©thode dâ€™Ã©chantillonnage non probabiliste dite par choix raisonnÃ©, et menÃ©e Ã partir dâ€™entretiens semi-dirigÃ©s avec une vingtaine dâ€™individus. En matiÃ¨re de rÃ©sultats, lâ€™Ã©tude a mis en exergue la position sociale comme facteur dÃ©terminant dans la prise de parole, le droit Ã la parole Ã©tant lÃ©gitimÃ© par des facteurs socio-Ã©conomiques. Aussi, la propagande mÃ©diatique du modÃ¨le dÃ©mocratique occidental a contribuÃ© Ã modifier les logiques communicationnelles Ã Baazra. Toutes ces mutations sont la base des conflits communautaires ; dâ€™oÃ¹ le recours Ã la mÃ©diation des pouvoirs publics qui est souvent contestÃ©.
This paper focuses on understanding the communicational dynamics, its causes, and its consequences in Baazraâ€“â€“a village located at the municipality of Zuenoula in the mid-west of CÃ´te dâ€™Ivoire. This qualitative study is based on a non-probability sampling approach which is known as a purposive sampling. It was carried out through semi-structured interviews administered to twenty respondents. The results of this survey show that the social position is a determining factor in speaking. In other words, the right to speak is inherent to socioeconomic factors. Moreover, the media propaganda of the western democratic model has contributed in changing the communicational logics in Baazra. All these changes forms the basis for community conflicts; hence this has resorted to the mediation of State authorities which is often contested.