bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wartości patriotyczne w doświadczeniu polskich migrantów w Wielkiej Brytanii
Authors: Adamczyk Tomasz 
Published: June 2020

Celem artykułu było ukazanie wartości patriotycznych w doświadczeniu polskich migrantów w Wielkiej Brytanii. Analizie został poddany materiał empiryczny zebrany metodą badań jakościowych przy pomocy techniki wywiadu pogłębionego. Materiał analizowany był z uwzględnieniem trzech zagadnień: poczucia dumy z bycia Polakiem, stosunku do ojczyzny oraz sposób podtrzymywania i rozwijania polskości. Socjologiczna analiza wskazała, że w społeczeństwach wielokulturowych zmiany w podejściu do wartości patriotycznych przebiegają w różnych kierunkach. U części migrantów wartości te zanikają, podczas gdy u innych są kultywowane, odkrywane i nawet rozwijane.
Current Management of Localized Muscle-Invasive Bladder Cancer: A Consensus Guideline from the Genitourinary Medical Oncologists of Canada
Authors: Jiang Di Maria , North Scott A. , Canil Christina , Kolinsky Michael , Wood Lori A. , Gray Samantha , Eigl Bernhard J. , Basappa Naveen S. , Blais Normand , Winquist Eric , Mukherjee Som D. , Booth Christopher M. , Alimohamed Nimira S. , Czaykowski Piotr , Kulkarni Girish S. , Black Peter C. , Chung Peter W. , Kassouf Wassim , van der Kwast Theodorus , Sridhar Srikala S. 
Published: June 2020

BACKGROUND: Despite recent advances in the management of muscle-invasive bladder cancer (MIBC), treatment outcomes remain suboptimal, and variability exists across current practice patterns. OBJECTIVE: To promote standardization of care for MIBC in Canada by developing a consensus guidelines using a multidisciplinary, evidence-based, patient-centered approach who specialize in bladder cancer. METHODS: A comprehensive literature search of PubMed, Medline, and Embase was performed; and most recent guidelines from national and international organizations were reviewed. Recommendations were made based on best available evidence, and strength of recommendations were graded based on quality of the evidence. RESULTS: Overall, 17 recommendations were made covering a broad range of topics including pathology review, staging investigations, systemic therapy, local definitive therapy and surveillance. Of these, 10 (59% ) were level 1 or 2, 7 (41% ) were level 3 or 4 recommendations. There were 2 recommendations which did not reach full consensus, and were based on majority opinion. This guideline also provides guidance for the management of cisplatin-ineligible patients, variant histologies, and bladder-sparing trimodality therapy. Potential biomarkers, ongoing clinical trials, and future directions are highlighted. CONCLUSIONS: This guideline embodies the collaborative expertise from all disciplines involved, and provides guidance to further optimize and standardize the management of MIBC.
Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer’s Disease Treated with Escalating Doses for up to 133 Weeks
Authors: Guthrie Heather , Honig Lawrence S. , Lin Helen , Sink Kaycee M. , Blondeau Kathleen , Quartino Angelica , Dolton Michael , Carrasco-Triguero Montserrat , Lian Qinshu , Bittner Tobias , Clayton David , Smith Jillian , Ostrowitzki Susanne 
Published: June 2020

Background: Crenezumab is a fully humanized, monoclonal anti-amyloid-β immunoglobulin G4 antibody. Objective: This Phase Ib study (NCT02353598) evaluated the safety, tolerability, and pharmacokinetics of crenezumabat doses of ≤120 mg/kg administered intravenously every 4 weeks (q4w). Immunogenicity and exploratory biomarkers were also evaluated. Methods: In this multicenter, double-blind study, participants (aged 50–90 years) with mild-to-moderate Alzheimer’s disease (AD) and amyloid-positive positron emission tomography (PET) scan were randomized to receive crenezumab 30 or 45 mg/kg (Cohort 1, n = 21), 60 mg/kg (Cohort 2, n = 21), or 120 mg/kg (Cohort 3, n = 19) or corresponding placebo ( n = 14) intravenously q4w for 13 weeks. Seventy-one participants were subsequently enrolled in an optional open-label extension (OLE) and received crenezumab at the originally assigned dose level, except for Cohort 3 (crenezumab 60 mg/kg during OLE). Participants received regular brain MRIs to assess amyloid-related imaging abnormalities (ARIA). Results up to Week 133 are reported. Results: Approximately 94% of participants experienced ≥1 adverse event (AE). Most AEs were mild or moderate; 15.5% experienced a Grade ≥3 AE. No ARIA-edema/effusion (ARIA-E) events were observed. New ARIA-micro hemorrhages and hemosiderosis (ARIA-H) were reported in 4.9% (double-blind treatment period) and 9.9% (combined double-blind treatment and OLE periods) of participants. Steady-state trough concentrations of crenezumab were dose-proportional and maintained for each dose level. Conclusion: Crenezumab doses of ≤120 mg/kg intravenously q4w were well tolerated. The observed safety profile for ≤133 weeks of treatment in a mild-to-moderate AD population was similar to that seen in previous trials.
Simple and Fast Assay for Apolipoprotein E Phenotyping and Glycotyping: Discovering Isoform-Specific Glycosylation in Plasma and Cerebrospinal Fluid
Authors: Hu Yueming , Meuret Cristiana , Go Scholastica , Yassine Hussein N. , Nedelkov Dobrin 
Published: June 2020

Background: The mechanisms of how APOE ɛ4 allele ( APOE4) increases the risk of Alzheimer’s disease (AD) pathology have not been fully elucidated. In cerebrospinal fluid (CSF), apoE is heavily glycosylated. Objective: To determine the impact of APOE genotype on the relative abundance of apoE protein isoforms and their specific glycosylation patterns in CSF and plasma via a newly developed mass spectrometric immunoassay (MSIA) assay. Methods: Total glycosylation and isoform-specific glycosylation were analyzed in plasma and CSF from a group of non-demented older individuals ( n = 22), consisting of homozygous ɛ3 and ɛ4 or heterozygous ɛ3/ ɛ4, ɛ2/ ɛ3, or ɛ2/ ɛ4 carriers. The glycan structures were further confirmed after treatment with sialidase. Results: In heterozygous individuals, the apoE3/E2, E4/E2, and E4/E3 isoform ratios were all significantly lower in plasma compared to CSF. For all individuals, a single O-linked glycan was observed in plasma, while two glycans (of the same type) per apoE were observed in CSF. The ratio of glycosylated to total apoE was greater in CSF compared to plasma for all apoE isoforms. In plasma and CSF, a trend of decreasing glycosylation was observed from apoE2 > apoE3 > apoE4. The difference in the percentage of secondary glycosylation in CSF was significantly greater in apoE4 compared to the other isoforms. Conclusion: The new MSIA apoE assay robustly distinguishes among apoE isoforms and glycoforms in plasma and CSF. ApoE4 is the predominant isoform and least glycosylated in CSF. Assessing apoE isoform-specific glycosylation by MSIA may help clarify brain apoE metabolism and AD risk.
Interviews with family caregivers of older adults: Their experiences of care and the integration of assistive technology in care
Authors: Beaudoin Maude , Atoyebi Oladele A. , Mortenson W. Ben , Auger Claudine , Demers Louise , Wister Andrew , Plante Michelle , Routhier François 
Published: June 2020

BACKGROUND: Consequences related to caregiving are multidimensional. Ways to reduce burden should be investigated, such as the use of assistive technology (AT). AT can decrease family caregiver burden, but there are multiple barriers to their uptake. A mixed-method project was launched to understand the needs of family caregivers and how could technology provide support. This study draws from qualitative data of this project. OBJECTIVE: To understand the experience of care provision and the integration of AT in the care provided by family caregivers. METHODS: Participants had to have provided care to an older adult or be an older adult providing care. Data collection consisted of semi-structured interviews on the caregiving situation and use of AT. A thematic content analysis was conducted. RESULTS: Fifty-nine family caregivers were recruited. Three main themes were identified: ‘Responsibilities of Caregiving’ described that family caregivers assisted in all areas of their care recipient’s life. ‘Caregivers’ Challenges and Rewards’ portrayed the challenges experienced by family caregivers and identified positive caregiving activities. ‘Strategies to Address Responsibilities and Challenges’ illustrated two main strategies to face challenges: sharing caring and using AT. CONCLUSION: The variability in care provision and challenges encountered should be taken into consideration when developing AT.
Trombosis senovenosa cerebral en un recién nacido con mutación MTHFR C677T tratado con enoxaparina
Authors: Fasce Juan , Calbacho Marcela , Oyarzún María , Reinbach Hoffman Katya , Daza Ariadna , García-Alix Alfredo 
Published: June 2020

La trombosis senovenosa cerebral neonatal (TSVC), es una patología rara y generalmente grave, de la cual se conoce poco sobre los mecanismos fisiopatológicos responsables y, aunque controvertido, se ha sugerido que la trombofilia genética, puede desempeñar un rol en la patogénesis. Debido a los temores de un sangrado intracraneal el tratamiento anticoagulante con heparina de bajo peso molecular es controvertido.Objetivo: presentar un recién nacido con una trombosis senovenosa cerebral neonatal, discutir los factores de riesgo trombofílico, y el manejo con heparina de bajo peso molecular de la trombosis venosa cerebral.Caso Clínico: Recién nacido de término que debutó a los 8 días de vida con convulsiones clónicas, rechazo al pecho más hipoactividad motora. La neuroimagen con RM mostró una TSVC involucrando múltiples senos venosos, un infarto hemorrágico talámico derecho y congestión venosa de la sustancia blanca frontal. El estudio de trombofilia puso de relieve una mutación homocigota del gen MTHFR C677T. El tratamiento con heparina de bajo peso molecular se asoció a repermeabilización del seno sagital superior a los 23 días de iniciada la terapia.Conclusiones: La presentación clínica de la TSVC en el neonato es inespecífica, probablemente en relación con la extensión y gravedad de la lesión y el desarrollo de complicaciones asociadas, como infartos hemorrágicos venosos intraparenquimatosos o hemorragia intraventricular. Estas complicaciones son detectables mediante Ecografia o Resonancia Magnética, y deben hacer sospechar una TSVC. En esta experiencia el tratamiento anticoagulante mostró ser seguro y prevenir la extensión de la trombosis.
“Till I in hand her yet halfe trembling tooke”: Doctrines of Justification in Edmund Spenser’s <i>Amoretti</i>
Authors: Shufran Lauren 
Published: June 2020

This article claims there is an underlying soteriological conceit in Spenser’s Amoretti (1595) concerning the roles that “works” and “grace” play in the beloved’s requital: roles with theological analogues in justification, the means by which people were declared righteous before God. I show how Spenser’s lover struggles with works-righteousness, and how Spenser betrays “Protestant” thought about the inadequacy of works even as his lover insists upon them. Spenser’s lover fails repeatedly in his labours until grace comes to him, unwilled, in a moment of concession. His “works” afterward become meaningful—but only according to the reformed understanding by which good works come after faith. Still, a doctrinal line cannot be perfectly drawn, since requital is effected through poetic labour. I propose this irresolution is a consequence of Spenser’s attention to Paul’s Epistles, and their occasional affirmations of the usefulness of law despite their overwhelming insistence on grace. It also stems from the lack of a reformed doctrinal consensus about the role of works after justification.
Cet article avance qu’il y a une dimension sotériologique sous-jacente dans l’Amoretti de Spenser (1595), en se basant sur le rôle des « oeuvres » et de la « grâce » dans la recompense du bien-aimé, rôle trouvant des correspondances théologiques dans la justification et les moyens par lesquels on est déclaré juste devant Dieu. On montre comment l’amoureux de Spenser lutte avec la notion de vertu par les oeuvres, et comment Spenser lui-même fait paraître des idées protestantes au sujet de l’insuffisance des oeuvres, même lorsque son personnage insiste sur leur utilité. Ainsi, le personnage de l’amoureux échoue systématiquement dans ses oeuvres, jusqu’à ce que la grâce lui soit octroyée, sans qu’il l’ait cherchée, et dans un moment de concession. Ce n’est qu’après cela que ses oeuvres trouvent une signification, mais seulement selon l’idée réformée que les bonnes oeuvres sont une conséquence de la foi. Toutefois, on ne peut déduire une ligne doctrinale parfaitement claire de l’oeuvre de Spenser, puisque la récompense y passe par le travail poétique. On propose d’expliquer cette ambivalence par l’attention que Spenser prête aux épîtres de Paul, lesquelles affirment occasionnellement l’utilité de la Loi malgré leur insistance répétée sur l’importance de la grâce. On peut également l’expliquer par l’absence de consensus doctrinal chez les Réformés quant au rôle des oeuvres après le salut par la foi.
Friction in the Archives: Storytelling in Sixteenth-Century Anabaptism
Authors: Lambert Erin 
Published: June 2020

The writings of martyrs have been at the centre of the history of Reformation-era Anabaptism since the sixteenth century itself, and scholars have long used them as sources of information about a persecuted and typically clandestine community. Based on a rare confluence in the surviving source material—a martyr’s prison letter and a repentant Anabaptist’s request for pardon that provide two different narratives of closely related events—this article reframes martyrological narratives as stories that reveal much about the subjectivity of their authors and the ways in which they shaped the early history of Anabaptism. At the same time, pardon tales can introduce new perspectives into historical narratives that were, over the course of centuries, inscribed as truth through communal practices of singing and reading.
Les écrits de martyrs ont été au centre de l’histoire de l’anabaptisme de la période de la Réforme dès le début du XVIe, et la recherche les a longtemps utilisés comme documents sur une communauté persécutée et typiquement clandestine. À partir d’une convergence remarquable entre les sources qui nous sont parvenues — la lettre d’un martyr emprisonné et la requête de pardon d’un anabaptiste repentant, donnant toutes deux un récit comparable des événements — cet article montre que ces récits de martyrs peuvent être revus de façon à révéler la subjectivité de leurs auteurs dans leur récit des débuts de l’anabaptisme. Simultanément, les récits de pardon peuvent amener une nouvelle perspective sur les récits de nature historique, et qui ont acquis, avec le temps, à travers les pratiques du chant et de la lecture en communauté, valeur de vérité.
“Real versus ideal”: <i>Utopia</i> and the Early Modern Satirical Tradition
Authors: Renner Bernd 
Published: June 2020

Building on previous studies of satire in Thomas More’s Utopia, this article aims at situating More’s founding text of utopian literature more firmly in the early modern satirical tradition, a tradition that gradually dissociated itself from its conventional generic definition informed by classical Roman verse satura. Key concerns of the analysis touch on the pedagogical function, the dialogic engagement with the reader, and the social reforming spirit that transform satire into a mode and help it incorporate the utopian mindset into its characteristic juxtaposition of blame (of a heavily flawed reality) and praise (of a desirable ideal state of existence). More’s masterpiece is essential in illustrating and promoting this development of early modern satire, as references to an immediate predecessor—the Ship of Fools corpus—as well as a famous successor—François Rabelais—demonstrate.
À partir d’études de la satire dans l’Utopie de More, cet article cherche à ancrer plus solidement ce texte utopique dans la tradition satirique de la première modernité, tradition qui s’est graduellement dissociée de la définition générale du genre satirique basée sur la satire classique romaine. Les points principaux de l’analyse mettent en lumière la fonction pédagogique, l’engagement dialogique avec le lecteur et l’esprit de réforme sociale, qui transforment la satire en y intégrant la pensée utopique en tant que façon d’exprimer le blâme (d’une réalité sérieusement déficiente) et la louange (d’un mode hautement souhaitable d’exister). Le chef-d’oeuvre de More occupe une place centrale dans ce développement de la satire des débuts de la modernité, lorsqu’il est situé dans les contextes qui le précèdent immédiatement — le corpus de la Nef des fous —, et le suivent glorieusement — l’oeuvre de François Rabelais.
“[T]he fault of the man and not the poet”: Sidney’s Troubled Double Vision of Thomas More’s <i>Utopia</i>
Authors: Lochman Daniel T. 
Published: June 2020

In the Defence of Poesy, Philip Sidney refers puzzlingly to Thomas More and Utopia. He praises the “way” this work presents a commonwealth yet faults the man who produced it. Sidney might have followed religious writers who condemned More’s Catholicism and his use of poetic fictions rather than direct assertions of what is true. In context, though, Sidney implies that his equivocation stems from More’s inconclusive dialogue and speculative discourse: genres he deems less effective than narrative in compelling readers to act virtuously. When revising his Arcadia, Sidney tests the poetics outlined in the Defence: a lengthy dialogue is interrupted by new episodes as narrative rises above rational debate and as characters become more obviously dominated by passion, not reason. Sidney’s revisions correspond to reassessments of Utopia at the turn of the century: its wit and poetry could be admired, yet its hybrid, contemplative genres seemed less compelling than narratives whose delight invites virtuous action.
Dans sa Defence of Poesy, Philip Sidney se réfère inexplicablement à Thomas More et à son Utopie. Il y loue comment cet ouvrage met en avant un bien commun, tout en trouvant bien des failles à son auteur. Sidney était peut-être d’accord avec certains auteurs religieux ayant condamné le catholicisme de More, ainsi que les fictions poétiques que la République condamne. Toutefois, considérant son propos dans son contexte, Sidney avance que son ambivalence s’explique par l’absence de conclusion du dialogue et le discours spéculatif de More, c’est-à-dire des styles qu’il considère moins à même que la narration de pousser le lecteur à la vertu. Lorsqu’il révise son Arcadia, Sidney met à l’épreuve la poétique qu’il a développée dans sa Defence : un dialogue s’étirant en longueur est interrompu par de nouveaux épisodes, et le récit prend le pas sur le débat rationnel, alors que les personnages se laissent visiblement plus emporter par la passion que par la raison. Les révisions de Sidney correspondent aux réexamens de l’Utopie au tournant du siècle. Il était possible d’admirer l’esprit et la poésie de More, mais son style hybride et contemplatif semble avoir été moins efficace que la narration, qui, elle, invite à la vertu par le plaisir qu’elle provoque.
All That Glitters: Devaluing the Gold Standard in the Utopias of Thomas More, Francis Bacon, and Margaret Cavendish
Authors: Martin Catherine Gimelli 
Published: June 2020

Francis Bacon’s and Margaret Cavendish’s ideal societies unexpectedly follow Thomas More’s Utopia in eliminating the exchange value of gold and replacing it with a knowledge economy. Bacon’s New Atlantis (1627) and Cavendish’s Blazing World (1666) similarly pursue new “light” and shun selfish profit, private trade, capital accumulation, and conspicuous consumption. Unlike More, they allow gold to retain its traditional decorative and symbolic functions, but its “use value” completely trumps its exchange value. Cavendish uses gold to construct and glorify her Blazing World and to forge astonishing defensive weapons, but it cannot be bought, sold, or even earned since it remains exclusively imperial. Bacon restricts gold to buying new “light” or knowledge and honouring thriving families with symbolic golden grape clusters, but like the Fathers of Salomon’s House, all three societies value only beneficial knowledge and the collaborative virtues taught by their new or improved religions to further universal peace and brotherhood.
Les sociétés idéales imaginées par Francis Bacon et Margaret Cavendish emboîtent étonnamment le pas à l’Utopie de Thomas More lorsqu’elles éliminent la valeur monétaire de l’or pour la remplacer par une économie du savoir. La New Atlantis de Bacon (1627) et le Blazing World de Cavendish (1666) proposent de façon comparable la quête d’une nouvelle lumière et le refus du profit égoïste, du commerce privé, de l’accumulation du capital et de la consommation ostentatoire. Toutefois, à la différence de More, ils permettent que soit maintenue la valeur esthétique et symbolique de l’or, qui éclipse ainsi complètement sa valeur de monnaie d’échange. Cavendish utilise l’or pour construire et glorifier son univers flamboyant et pour créer d’étonnantes armes défensives, mais il ne peut être ni acheté, ni vendu, ni même gagné, puisqu’il est exclusivement impérial. Bacon limite l’usage de l’or à l’achat d’une nouvelle lumière, c’est-à-dire de la connaissance, et à l’hommage des familles florissantes en leur offrant de symboliques grappes de raisins en or, mais tout comme les Pères de la Maison de Salomon, cettes trois sociétés valorisent uniquement la connaissance bénéfique et les vertus de collaboration qu’enseignent leur religion nouvelle et améliorée afin de favoriser la paix universelle et la fraternité.
Bioremediation Experiment Using Hydrocarbon Degrading Bacteria
Authors: Susilawati Rita 
Published: June 2020

A laboratory experiment was set up to demonstrate the capability of microbe to remediate petroleum hydrocarbon contaminated beach sand. Oil contaminated soil was used as a source of inoculum for hydrocarbon degrading bacteria (HDB) while oil contaminated beach sand was used as remediation object. The growth of HDB in the inocula was enriched and stimulated through the addition of nutrient in the form of vitamin and mineral as well the addition of oil waste as a source of carbon. Experiment took place in the course of approximately five weeks. Microscopic observation clearly showed the interaction between microbe and oil contaminant both in enrichment and bioremediation samples. The result of the experiment also suggests that approximately 25% of the petroleum hydrocarbon mass in the contaminated beach sand was biodegraded over the course of one month. Overall, the results of this experiment suggest the potential of bioremediation method to treat petroleum hydrocarbon polluted environment.Keywords: bacteria, bioremediation, hydrocarbon DOI: 10.33332/jgsm.2019.v20.1.1-7