bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating tumor cells are an indicator for the administration of adjuvant transarterial chemoembolization in hepatocellular carcinoma: A single‐center, retrospective, propensity‐matched study
Authors: Wang Peng‐Xiang , Sun Yun‐Fan , Zhou Kai‐Qian , Cheng Jian‐Wen , Hu Bo , Guo Wei , Yin Yue , Huang Jun‐Feng , Zhou Jian , Fan Jia , Cheung Tan To , Qu Xu‐Dong , Yang Xin‐Rong 
Published: July 2020

AbstractBackgroundHigh rates of postoperative tumor recurrence contribute to poor outcome in hepatocellular carcinoma (HCC). Here, we investigated whether circulating tumor cells (CTCs) status can predict the benefit of adjuvant transcatheter arterial chemoembolization (TACE) in patients with HCC.MethodsThe retrospective study enrolled 344 HCC patients with preoperative CTCs analysis. Clinical outcomes including recurrence and survival were compared between those who received and who did not receive adjuvant TACE. Similar comparisons were made for patients stratified according to CTC status (CTC‐negative [CTC = 0], n = 123; CTC‐positive [CTC ≥ 1], n = 221). Propensity score matching (PSM) strategy was adopted to offset differences between two groups.ResultsIn the study cohort as a whole or in CTC‐negative cohort, there were no observable differences in overall survival (OS) or time to recurrence (TTR) between TACE and control group (P > .05). In CTC‐positive patients, PSM generated 64 patient pairs, and patients with adjuvant TACE had significantly better clinical outcomes (OS: not reached vs 36.4 months, P < .001; TTR: 45.8 vs 9.8 months, P < .001). Adjuvant TACE significantly reduced early recurrence (≤2 years) (64.1% vs 31.7%, P < .001) in CTC‐positive patients. Notably, adjuvant TACE influenced TTR and OS even in subgroups of CTC‐positive patients with low risk of recurrence according to traditional evaluation.ConclusionsPreoperative CTC status could serve as an indicator for the administration of adjuvant TACE in HCC patients. Adjuvant TACE benefits CTC‐positive HCC patients mainly by reducing early recurrence.
Plasma‐on‐Chip: device for non‐thermal atmospheric pressure plasma irradiation to single cells
Authors: Kumagai Shinya , Kobayashi Mime , Shimizu Tetsuji , Sasaki Minoru 
Published: July 2020

AbstractWe report an improvement of the Plasma‐on‐Chip device that enables plasma irradiation to single cells. Dielectric barrier discharge structure was introduced and power consumption was reduced to 200 µW. The modification extended the operation time of the Plasma‐on‐Chip device. As long as 10 min plasma irradiation to yeast cells, Saccharomyces cerevisiae was conducted.
Ground motion spatial correlation fitting methods and estimation uncertainty
Authors: Baker Jack W. , Chen Yilin 
Published: July 2020

SummaryGround shaking intensity varies spatially in earthquakes, and many studies have estimated correlations of intensity from past earthquake data. This paper presents a framework for quantifying uncertainty in the estimation of correlations and true variability in correlations from earthquake to earthquake. A procedure for evaluating estimation uncertainty is proposed and used to evaluate several methods that have been used in past studies to estimate correlations. The results indicate that a weighted least squares algorithm is most effective in estimating spatial correlation models and that earthquakes with at least 100 recordings are needed to produce informative earthquake‐specific estimates of spatial correlations. The proposed procedure is also used to distinguish between estimation uncertainty and the true variability in model parameters that exist in a given data set. The estimation uncertainty is seen to vary between well‐recorded and poorly recorded earthquakes, whereas the true variability is more stable.
Combined support technology for main roadway passing through goaf: A case study
Authors: Chen Dongdong , Zhang Qing , Xie Shengrong , Jiang Zaisheng , Li Yubo , Gao Mingming , Li Hui , Wu Xiaoyu , Wang En , Shi Songhao , Wang Long 
Published: July 2020

AbstractControlling the surrounding rock of the main roadway passing through a goaf during the reconstruction and expansion of a merger and reorganization mine is a common challenge in underground mining practices. In this study, a combined support technology of roof “anchorage‐mesh‐shotcrete” and a double‐H‐type space frame structure for a main roadway passing through a goaf was studied using field investigations, theoretical analysis, and engineering practice. It was observed that the main roadway control difficulties lie in the strongly mining‐induced roof strata in the early stages, with collapsed gangues not connected to an unsupported roof, large goaf sections, and multiple superpositions of surrounding rock stress fields with complex distributions. Based on the results, a double‐H‐type space frame structure support system comprising a “reinforced concrete pillar + reinforced concrete longitudinal beam + cross steel I‐beam” was constructed. This provided strong pillar support, enhanced the shock resistance of the roof, improved the bending and lateral pressure resistances of the frame structure, and produced airtight spaces for the main roadway. Accordingly, a “double systems” support scheme was designed. The results of the engineering practice indicated that the deformation of the goaf roof and force of the supporting structure were controlled within a safe range, meeting the requirements for mine ventilation, pedestrians, and haulage. Consequently, the surrounding rock control problem for the main roadway passing through the goaf was effectively solved, and theoretical and technical bases were provided for the stability control of a roadway passing through a goaf under similar conditions.
Cone penetration testing for extensive mapping of deeply buried Late Glacial coversand landscape paleotopography
Authors: Verhegge Jeroen , Storme Annelies , Cruz Frédéric , Crombé Philippe 
Published: July 2020

AbstractLate Glacial coversand landscapes are important archives of environmental change during the Pleistocene–Holocene transition as well as of Final Paleolithic human adaptation to these changes. However, extensive reconstruction of these landscapes is hampered by the fact that they are often preserved best when covered with later eolian, alluvial and/or marine sediments. These paleolandscapes are generally mapped by means of manual or mechanical coring to date, which is rather expensive and labor‐intensive. This study aims to develop a more efficient methodology to map paleolandscapes buried within the coversand and below Holocene floodplain deposits, using a case study in NW Belgium. Electric cone penetration testing is established as a primary technique for mapping the paleotopography of thin organic rich layers within the coversand, in combination with core sampling for lithostratigraphic correlation and validation. Radiocarbon dating and pollen analyses are used to investigate the chronological and biostratigraphic context, respectively. The results reveal the paleotopography of three undulating organic rich stabilization surfaces within the coversand, which were formed from the GI‐1d to GI‐1a. These paleosurfaces provide valuable contexts for studying Final Paleolithic archaeology in the coversand region specifically, but the developed methodology is applicable to Paleolithic archaeology in general.
Choosing the optimal HPV vaccine: The health impact and economic value of the nonavalent and bivalent HPV vaccines in 48 Gavi‐eligible countries
Authors: Burger Emily A. , Portnoy Allison , Campos Nicole G. , Sy Stephen , Regan Catherine , Kim Jane J. 
Published: July 2020

AbstractThe human papillomavirus (HPV) vaccines may provide some level of cross‐protection against high‐risk HPV genotypes not directly targeted by the vaccines. We evaluated the long‐term health and economic impacts of routine HPV vaccination using either the nonavalent HPV vaccine or the bivalent HPV vaccine in the context of 48 Gavi‐eligible countries. We used a multi‐modeling approach to compare the bivalent with or without cross‐protection and the nonavalent HPV vaccine. The optimal, that is, most cost‐effective, vaccine was the vaccine with an incremental cost‐effectiveness ratio below the per‐capita gross domestic product (GDP) for each country. By 2100 and assuming 70% HPV vaccination coverage, a bivalent vaccine without cross‐protection, a bivalent vaccine with favorable cross‐protection and the nonavalent vaccine were projected to avert 14.9, 17.2 and 18.5 million cumulative cases of cervical cancer across all 48 Gavi‐eligible countries, respectively. The relative value of the bivalent vaccine compared to the nonavalent vaccine increased assuming a bivalent vaccine conferred high cross‐protection. For example, assuming a cost‐effectiveness threshold of per‐capita GDP, the nonavalent vaccine was optimal in 83% (n = 40) of countries if the bivalent vaccine did not confer cross‐protection; however, the proportion of countries decreased to 63% (n = 30) if the bivalent vaccine conferred high cross‐protection. For lower cost‐effectiveness thresholds, the bivalent vaccine was optimal in a greater proportion of countries, under both cross‐protection assumptions. Although the nonavalent vaccine is projected to avert more cases of cervical cancer, the bivalent vaccine with favorable cross‐protection can prevent a considerable number of cases and would be considered a high‐value vaccine for many Gavi‐eligible countries.
Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS‐CoV‐2 infection among hospitalized pregnant women: A systematic review
Authors: Turan Ozlem , Hakim Amir , Dashraath Pradip , Jeslyn Wong Jing Lin , Wright Alison , Abdul‐Kadir Rezan 
Published: July 2020

AbstractBackgroundPregnant women represent a potentially high‐risk population in the COVID‐19 pandemic.ObjectiveTo summarize clinical characteristics and outcomes among pregnant women hospitalized with COVID‐19.Search strategyRelevant databases were searched up until May 29, 2020.Selection criteriaCase series/reports of hospitalized pregnant women with laboratory‐confirmed COVID‐19.Data collection and analysisPRISMA guidelines were followed. Methodologic quality was assessed via NIH assessment tools.Main resultsOverall, 63 observational studies of 637 women (84.6% in third trimester) with laboratory‐confirmed SARS‐CoV‐2 infection were included. Most (76.5%) women experienced mild disease. Maternal fatality, stillbirth, and neonatal fatality rates were 1.6%, 1.4%, and 1.0%, respectively. Older age, obesity, diabetes mellitus, and raised serum D‐dimer and interleukin‐6 were predictive of poor outcomes. Overall, 33.7% of live births were preterm, of which half were iatrogenic among women with mild COVID‐19 and no complications. Most women underwent cesarean despite lacking a clear indication. Eight (2.0%) neonates had positive nasopharyngeal swabs after delivery and developed chest infection within 48 hours.ConclusionsAdvanced gestation, maternal age, obesity, diabetes mellitus, and a combination of elevated D‐dimer and interleukin‐6 levels are predictive of poor pregnancy outcomes in COVID‐19. The rate of iatrogenic preterm birth and cesarean delivery is high; vertical transmission may be possible but has not been proved.
Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: The role of GABAergic neurotransmission
Authors: Aghighi Bidgoli Fatemeh , Salami Mahmoud , Talaei Sayyed Alireza 
Published: July 2020

AbstractEvidence shows that prenatal stress negatively affects cognitive functions and activity of neuronal circuits in postnatal age. Environmental enrichment counteracts deficits induced by early life stress. We examined if behavioural function and synaptic plasticity are sensitive to prenatal stress and, how much environmental enrichment and GABAergic system impact these phenomena. Animals were exposed to noise stress during the third trimester of foetal life. Groups of the stressed animals remained intact (S‐SH) or received enrichment (S‐EE) from postnatal day 22 for one month. Also, two groups received either saline (S‐SH‐S) or bicuculline (S‐SH‐B). One enriched group received muscimol (S‐EE‐M). The control groups were intact (C‐SH), enriched (C‐EE), or received bicuculline (C‐SH‐B) or saline (C‐SH‐S). We assessed learning and memory and, hippocampal long‐term potentiation (LTP). Serum corticosterone levels were detected as a measure of stress condition. We found that stress reduced spatial performance and suppressed LTP in the S‐SH animals. Postnatal enrichment restored both spatial learning and memory and synaptic plasticity in the S‐EE rats. GABAergic antagonism strengthens maze performance and LTP induction in the S‐SH‐B group. However, muscimol prevented the positive effects of enrichment in the S‐EE‐M animals. Environmental enrichment and GABAergic modulation may improve disrupted spatial performance and synaptic plasticity.
Global Research Alliance N2O chamber methodology guidelines: Introduction, with health and safety considerations
Authors: de Klein Cecile A. M. , Harvey Mike J. , Clough Tim J. , Petersen Søren O. , Chadwick David R. , Venterea Rodney T. 
Published: July 2020

AbstractNon‐steady‐state (NSS) chamber techniques have been used for decades to measure nitrous oxide (N2O) fluxes from agricultural soils. These techniques are widely used because they are relatively inexpensive, easy to adopt, versatile, and adaptable to varying conditions. Much of our current understanding of the drivers of N2O emissions is based on studies using NSS chambers. These chamber techniques require decisions regarding multiple methodological aspects (e.g., chamber materials and geometry, deployment, sample analysis, and data and statistical analysis), each of which may significantly affect the results. Variation in methodological details can lead to challenges in comparing results between studies and assessment of reliability and uncertainty. Therefore, the New Zealand Government, in support of the objectives of the Livestock Research Group of the Global Research Alliance on Agricultural Greenhouse Gases (GRA), funded two international projects to, first, develop standardized guidelines on the use of NSS chamber techniques and, second, refine them based on the most up to date knowledge and methods. This introductory paper summarizes a collection of papers that represent the revised guidelines. Each article summarizes existing knowledge and provides guidance and minimum requirements on chamber design, deployment, sample collection, storage and analysis, automated chambers, flux calculations, statistical analysis, emission factor estimation and data reporting, modeling, and “gap‐filling” approaches. The minimum requirements are not meant to be highly prescriptive but instead provide researchers with clear direction on best practices and factors that need to be considered. Health and safety considerations of NSS chamber techniques are also provided with this introductory paper.
Whether, when, and how to communicate genetic risk to minors: ‘I wanted more information but I think they were scared I couldn’t handle it’
Authors: Stuttgen Kelsey , McCague Allison , Bollinger Juli , Dvoskin Rachel , Mathews Debra 
Published: July 2020

AbstractGenetic test results are often relevant not only to persons tested, but also to their children. Questions of whether, when, and how to disclose parental test results to children, particularly minors, can be difficult for parents to navigate. Currently, limited data are available on these questions from the perspective of minors. In this qualitative study, semi‐structured interviews were conducted with parents affected by or at risk for hereditary cancer (N = 17) or Huntington's disease (N = 14) and their mature minor children aged 15–17 (N = 34). Parents and mature minors were interviewed separately. Genetic counselors (GCs; N = 19) were also interviewed. Most parents interviewed wanted to protect minors from genetic risk information (GRI) and feared minors would not be able to handle GRI. However, most mature minors reported they did not receive enough information and wished their parent was more forthcoming. Parents recommended taking time to process one's own test results before communicating with minors, and mature minors recommended parents communicate GRI in an honest, hopeful way. Most parents and GCs felt additional resources on communicating with minors about GRI and various genetic conditions are needed. This study includes the experiences and perspectives of a well‐informed cohort, and results should be taken into careful consideration by parents, GCs, and others who are faced with communicating GRI to minors.
Recent progress on coumarinscaffold‐basedanti‐microbial agents (PartIII)
Authors: Gouda Moustafa. A. , Abu‐Hashem Ameen A. , Salem Mohammed A. , Helal Mohamed H. , Al‐Ghorbani Mohammed , Hamama Wafaa S. 
Published: July 2020

AbstractThe biological, therapeutic, and medicinal properties of coumarins (chromen‐2‐ones), and its analogs have triggered enormous studies aimed toward growing synthetic routes to these heterocyclic compounds. This review presents a systematic and comprehensive survey of the method of preparation, the chemical reactivity, and the anti‐microbial properties associated with this system.
Study of generalized formulation for augmented electric field integral equation with perturbation method
Authors: Chen Wenjing , Sun Sheng , Liu Yang G. , Liu Qin S. , Chen Yongpin , Hu Jun 
Published: July 2020

AbstractIn this work, a generalized form for the augmented electric field integral equation with perturbation method is studied. By implementing Taylor expansion on all the frequency‐dependent matrix terms and the unknowns, the current coefficients on each frequency order can be obtained in the perturbation method, where the accuracy can be guaranteed near the zero frequency or within the static frequency region. When the frequency goes higher, more expanding terms are required to obtain the accurate results. In order to obtain a wideband solution, a general formulation for the perturbation method is derived and analyzed for the first time. As a result, the improved method can be further extended to dynamic region. Numerical results show that the achieved results for both capacitive circuit problems and plane wave scattering problems are more accurate in comparison with those obtained from the traditional solutions, where the number of the required expanding terms can be determined according to the corresponding error analysis.
Capturing the state of the science to change the state of the science: A categorization approach to integrative reviews
Authors: Dwertmann David J. G. , van Knippenberg Daan 
Published: July 2020

SummaryIntegrative reviews, reviews of an area of research that not only describe the state of the science but also advance it through integration and synthesis of the evidence, make unique contributions to the literature. We discuss this unique value of integrative reviews, highlighting that integrative reviews of the literature are positioned in the conceptual space between descriptive reviews and theory papers, to position this study's focus: presenting an approach to conduct such reviews. This approach focuses on the systematic consideration of similarities and differences between findings, identifying the underlying categorizations that capture these similarities and differences, and developing new theory anchored on these categorizations for similarities and differences not predicted by existing theory. We outline how authors following this approach should make the different steps in this process of categorization and theory development transparent in their presentation to increase replicability of the review and more precisely identify the locus of potential disagreements concerning the conclusions of the review. Following these steps also provides clearer anchors to assess the validity of the conclusions of the review in the publication process, for readers, and in follow‐up primary research.
Influence of epicatechin on oxidation‐induced physicochemical and digestibility changes in porcine myofibrillar proteins during refrigerated storage
Authors: Xu Mingfeng , Sun Manfei , Lu Cairu , Han Yating , Yao Xing , Niu Xiaoying , Xu Maojun , Zhu Qin 
Published: July 2020

AbstractBACKGROUNDThe influence of epicatechin (EC) on the physicochemical properties and digestibility changes of porcine myofibrillar protein (MP) under oxidative stress during refrigerated storage was investigated.RESULTSThe incubation of MP suspensions (20 mg mL−1 in piperazine‐N,N′‐bis(2‐ethanesulfonic acid) buffer, with 0.6 mol L−1 sodium chloride, pH 6.25) at 4 °C for 24 h under an iron‐catalyzed hydroxyl radical generating system (Fenton reaction) promoted the formation of thiobarbituric acid reactive substances and protein carbonyls, which was attenuated by EC (5, 50, and 100 μmol g−1 protein). Reduced protein sulfhydryl content, tryptophan fluorescence, protein solubility, as well as increased surface hydrophobicity were found by the co‐incubation of EC. Analysis by scanning electron microscopy revealed increased protein aggregation and fragments in oxidized MP, which were further enhanced by the addition of EC. However, the protein digestibility of MP was not affected.CONCLUSIONEC was demonstrated to be effective in alleviating lipid oxidation and protein carbonylation in MP under oxidative stress. Additionally, the physicochemical and digestibility changes accompanying the incorporation of EC was complicated due to the possible phenol–protein interactions. An in‐depth understanding of protein physicochemical and digestibility changes will be helpful in the application of polyphenolic compounds as antioxidants in low‐temperature‐processed muscle foods. © 2020 Society of Chemical Industry
Physico‐chemical characterization of Cornus kousa Burg. fruit: determining optimal maturity for fresh consumption
Authors: Schmitzer Valentina , Sircelj Helena , Stampar Franci , Slatnar Ana 
Published: July 2020

AbstractBACKGROUNDJapanese dogwood (Cornus kousa Burg.) is a popular ornamental plant which develops edible compound fruit utilized in traditional Asian medicine. Previous compositional studies have focused on a small fraction of secondary metabolites at a single maturity stage. In order to address the question of optimal ripeness of Japanese dogwood fruit for consumption the study provides a comprehensive insight into its primary and secondary metabolic profile.RESULTSThe aim of the study was to investigate biochemical composition and morphological traits of Japanese dogwood (Cornus kousa Burg.) fruit at four maturity stages: GF, green fruit; BF, fruit with a defined red blush; RF, ripe fruit; OF, over‐ripe fruit. Fruit was characterized by a nearly spherical shape, decreased water content in later stages of ripeness and highest a* values at RF and OF stages. Total sugars increased significantly from GF to OF stage and total organic acids and vitamin C decreased with maturation. Japanese dogwood fruit was characterized by four major phenolic groups: anthocyanins (three), flavonols (eight) hydroxycinnamic acids (three) and flavonoids (one) as well as by four lipophilic antioxidants: tocopherols (two), xanthophylls (five), carotenes (two) and chlorophylls (two). The progression of fruit ripening caused faster accumulation of individual phenolic compounds and lipophilic antioxidants which resulted in significantly higher total phenolic content at the RF and OF stages.CONCLUSIONJapanese dogwood fruit is a rich alternative source of ascorbic acid, α‐tocopherol, flavonols and anthocyanins and should be consumed fresh at fully developed red colour of compound berries when their composition is optimal. © 2020 Society of Chemical Industry