bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Inertial Instability in Cross-Hemispheric Coupling
Authors: Lieberman R. S. , France J. , Ortland D. A. , Eckermann S. D. 
Published: January 2021

AbstractRecent studies suggest linkages between anomalously warm temperatures in the winter stratosphere, and the high-latitude summer mesopause. The summer temperature anomaly is manifested in the decline of polar mesospheric clouds. The 2-day wave is a strong-amplitude and transient summer feature that interacts with the background state so as to warm the high-latitude summer mesopause. This wave has been linked to a low-latitude phenomenon called inertial instability, which is organized by breaking planetary waves in the winter stratosphere. Hence, inertial instability has been identified as a possible nexus between the disturbed winter stratosphere, and summer mesopause warming. We investigate a sustained occurrence of inertial instability during 19 July–8 August 2014. During this period, stratospheric winter temperatures warmed by about 10 K, while a steep decline in polar mesospheric clouds was reported between 26 July and 6 August. We present, for the first time, wave driving associated with observed inertial instability. The effect of inertial instability is to export eastward momentum from the winter hemisphere across the equator into the summer hemisphere. Using a primitive equation model, we demonstrate that the wave stresses destabilize the stratopause summer easterly jet. The reconfigured wind profile excites the wavenumber-4 component of the 2-day wave, leading to enhanced warming of the summer mesopause. This work supports previous numerical investigations that identified planetary wave–driven inertial instability as a source of the 2-day wave.
On the Influence of Sea Surface Temperature Distributions on the Development of Extratropical Cyclones
Authors: Bui Hai , Spengler Thomas 
Published: January 2021

AbstractThe sea surface temperature (SST) distribution can modulate the development of extratropical cyclones through sensible and latent heat fluxes. However, the direct and indirect effects of these surface fluxes, and thus the SST, are still not well understood. This study tackles this problem using idealized channel simulations of moist baroclinic development under the influence of surface fluxes. The model is initialized with a zonal wind field resembling the midlatitude jet and a different SST distribution for each experiment, where the absolute SST, the SST gradient, and the meridional position of the SST front are varied. The surface latent heat flux associated with the absolute SST plays a key role in enhancing the moist baroclinic development, while the sensible heat fluxes associated with the SST gradient play a minor role that can be detrimental for the development of the cyclone. The additional moisture provided by the latent heat fluxes originates from about 1000 km ahead of the cyclone a day prior to the time of the most rapid deepening. When the SST in this region is higher than 16°C, the additional latent heat is conducive for explosive cyclone development. For SSTs above 20°C, the cyclones feature characteristics of hybrid cyclones with latent heat release close to their core, maintaining their intensity for a longer period due to continuous and extensive moisture supply from the surface. A high absolute SST with a weak SST gradient, however, can lead to a delay of the deepening stage, because of unorganized convection at early stages reducing environmental baroclinicity.
Support and Positioning Mechanism of a Detection Robot inside a Spherical Tank
Authors: Tu Chunlei , Jin Shanshan , Zheng Kai , Wang Xingsong , Sun Sichong 
Published: January 2021

AbstractLarge pressure equipment needs to be tested regularly to ensure safe operation; wall-climbing robots can carry the necessary tools to inspect spherical tanks, such as cameras and non-destructive testing equipment. However, a wall-climbing robot inside a spherical tank cannot be accurately positioned owing to the particularity of the spherical tank structure. This paper proposes a passive support and positioning mechanism fixed in a spherical tank to improve the adsorption capacity and positioning accuracy of the inspection robot. The main body of the mechanism was designed as a truss composed of carbon fiber telescopic rods and can work in spherical tanks with diameters of 4.6‒15.7 m. The structural strength, stiffness, and stability of the mechanism are analyzed via force and deformation simulations. By constructing a mathematical model of the support and positioning mechanism, the influence of structural deformation on the supporting capacity is analyzed and calculated. The robot positioning method based on the support and positioning mechanism can effectively locate the robot inside a spherical tank. Experiments verified the support performance and robot positioning accuracy of the mechanism. This research proposes an auxiliary support and positioning mechanism for a detection robot inside a spherical tank, which can effectively improve the positioning accuracy of the robot and meet the robotic inspection requirements.
Aerodynamic Characteristics of Isolated Loaded Tires with Different Tread Patterns: Experiment and Simulation
Authors: Zhou Haichao , Jiang Zhen , Wang Guolin , Zhang Shupei 
Published: January 2021

AbstractThe current research of tire aerodynamics mainly focus on the isolated and simplified tread tire. Compared with the real complex pattern tire, the tread pattern structure and deformed profile of a loaded tire has a greatly influence on tire aerodynamic drag. However, the mechanisms of the isolated loaded tires with different tread patterns effects on the aerodynamic drag are subjects worthy of discussion. The purpose of this study is to experimentally and computationally investigate the aerodynamic characteristics of three tires 185/65 R14 with different patterns under loaded. A wind tunnel test model was first established using three-dimensional (3D) printing with a ratio of 1:1, and the pressure coefficientsCpof the three tires with different patterns are measured. The paper then conducted computational fluid dynamics (CFD) simulations for analyzing the pressure and flow characteristics. The accuracy of CFD simulation is verified by comparing the simulation results with the test results of pressure coefficientsCp, and they are of good consistency. While, the general analysis of pressure coefficientsCpresults of the three tires indicates high-pressure area on the windward surface, and occurrence of low-pressure area on the leeward surface, the pressure coefficientsCpof all three tires decreased firstly and then increased along in the air flow direction. The authors finally analyzed the effect of tread patterns on the flow field around the tire and revealed the differences between flow characteristics and aerodynamic drag. The results show that, angle of tire lateral groove has great effect on the flow field characteristics such that; the more the angle of lateral groove agrees with the air flow direction, the less the flow separation and flow vortices, and a minimum observable aerodynamic drag. The research provides a guidance for the design of low aerodynamic drag tires, and helps to illustrate the impact of tire aerodynamics on the car body in the future.
Factors associated with survival of patients with solid Cancer alive after intensive care unit discharge between 2005 and 2013
Authors: Gheerbrant Hubert , Timsit Jean-François , Terzi Nicolas , Ruckly Stéphane , Laramas Mathieu , Levra Matteo Giaj , Jacquet Emmanuelle , Falque Loic , Moro-Sibilot Denis , Toffart Anne-Claire 
Published: January 2021

Abstract
Background
At intensive care unit (ICU) admission, the issue about prognosis of critically ill cancer patients is of clinical interest, especially after ICU discharge. Our objective was to assess the factors associated with 3- and 6-month survival of ICU cancer survivors.

Methods
Based on the French OutcomeRea™ database, we included solid cancer patients discharged alive, between December 2005 and November 2013, from the medical ICU of the university hospital in Grenoble, France. Patient characteristics and outcome at 3 and 6 months following ICU discharge were extracted from available database.

Results
Of the 361 cancer patients with unscheduled admissions, 253 (70%) were discharged alive from ICU. The main primary cancer sites were digestive (31%) and thoracic (26%). The 3- and 6-month mortality rates were 33 and 41%, respectively. Factors independently associated with 6-month mortality included ECOG performance status (ECOG-PS) of 3–4 (OR,3.74; 95%CI: 1.67–8.37), metastatic disease (OR,2.56; 95%CI: 1.34–4.90), admission for cancer progression (OR,2.31; 95%CI: 1.14–4.68), SAPS II of 45 to 58 (OR,4.19; 95%CI: 1.76–9.97), and treatment limitation decision at ICU admission (OR,4.00; 95%CI: 1.64–9.77). Interestingly, previous cancer chemotherapy prior to ICU admission was independently associated with lower 3-month mortality (OR, 0.38; 95%CI: 0.19–0.75). Among patients with an ECOG-PS 0–1 at admission, 70% (n = 66) and 61% (n = 57) displayed an ECOG-PS 0–2 at 3- and 6-months, respectively. At 3 months, 74 (55%) patients received anticancer treatment, 13 (8%) were given exclusive palliative care.

Conclusions
Factors associated with 6-month mortality are almost the same as those known to be associated with ICU mortality. We highlight that most patients recovered an ECOG-PS of 0–2 at 3 and 6 months, in particular those with a good ECOG-PS at ICU admission and could benefit from an anticancer treatment following ICU discharge.
Variceal bleeding is aggravated by portal venous invasion of hepatocellular carcinoma: a matched nested case-control study
Authors: Lim Jihye , Kim Ha Il , Kim Eunju , Kim Jiyoon , An Jihyun , Chang Seheon , Kim Seon-Ok , Lee Han chu , Lee Yung Sang , Shim Ju Hyun 
Published: January 2021

Abstract
Background
We hypothesized that portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) increases portal pressure and causes esophageal varices and variceal bleedings. We examined the incidence of high-risk varices and variceal bleeding and determined the indications for variceal screening and prophylaxis.

Methods
This study included 1709 asymptomatic patients without any prior history of variceal hemorrhage or endoscopic prophylaxis who underwent upper endoscopy within 30 days before or after initial anti-HCC treatment. Of these patients, 206 had PVTT, and after 1:2 individual matching, 161 of them were matched with 309 patients without PVTT. High-risk varices were defined as large/medium varices or small varices with red-color signs and variceal bleeding. Bleeding rates from the varices were compared between matched pairs. Risk factors for variceal bleeding in the entire set of patients with PVTT were also explored.

Results
In the matched-pair analysis, the proportion of high-risk varices at screening (23.0% vs. 13.3%; P = 0.003) and the cumulative rate of variceal bleeding (4.5% vs. 0.4% at 1 year; P = 0.009) were significantly greater in the PVTT group. Prolonged prothrombin time, lower platelet count, presence of extrahepatic metastasis, and Vp4 PVTT were independent risk factors related to high-risk varices in the total set of 206 patients with PVTT (Adjusted odds ratios [95% CIs], 1.662 [1.151–2.401]; 0.985 [0.978–0.993]; 4.240 [1.783–10.084]; and 3.345 [1.457–7.680], respectively; Ps < 0.05). During a median follow-up of 43.2 months, 10 patients with PVTT experienced variceal bleeding episodes, 9 of whom (90%) had high-risk varices. Presence of high-risk varices and sorafenib use for HCC treatment were significant predictors of variceal bleeding in the complete set of patients with PVTT (Adjusted hazard ratios [95% CIs], 26.432 [3.230–216.289]; and 5.676 [1.273–25.300], respectively; Ps < 0.05).

Conclusions
PVTT in HCC appears to increase the likelihood of high-risk varices and variceal bleeding. In HCC patients with PVTT, endoscopic prevention could be considered, at least in high-risk variceal carriers taking sorafenib.
The protocol of a prospective, multicenter, randomized, controlled phase III study evaluating different cycles of oxaliplatin combined with S-1 (SOX) as neoadjuvant chemotherapy for patients with locally advanced gastric cancer: RESONANCE-II trial
Authors: Wang Xinxin , Li Shuo , Sun Yihong , Li Kai , Shen Xian , Xue Yingwei , Liang Pin , Li Guoli , Chen Luchuan , Zhao Qun , Li Guoxin , Fu Weihua , Liang Han , Xin Hairong , Suo Jian , Fang Xuedong , Zheng Zhichao , Xu Zekuan , Chen Huanqiu , Zhou Yanbing , He Yulong , Huang Hua , Zhu Linghua , Yang Kun , Ji Jiafu , Ye Yingjiang , Zhang Zhongtao , Li Fei , Wang Xin , Tian Yantao , Park Sungsoo , Chen Lin 
Published: January 2021

Abstract
Background
Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with gastric cancer based on several clinical trials. According to phase II studies and guidelines, SOX regimen as neoadjuvant chemotherapy is efficient. However, the optimal duration of neoadjuvant chemotherapy has not been established. In this study, we will evaluate the efficacy and safety of different cycles of SOX as neoadjuvant chemotherapy for patients with locally advanced gastric cancer.

Methods
RESONANCE-II trial is a prospective, multicenter, randomized, controlled phase III study which will enroll 524 patients in total. Eligible patients will be registered, pre-enrolled and receive three cycles of SOX, after which tumor response evaluations will be carried out. Those who show stable disease or progressive disease will be excluded. Patients showing complete response or partial response will be enrolled and assigned into either group A for another three cycles of SOX (six cycles in total) followed by D2 surgery; or group B for D2 surgery (three cycles in total). The primary endpoint is the rate of pathological complete response and the secondary endpoints are R0 resection rate, three-year disease-free survival, five-year overall survival, and safety.

Discussion
This study is the first phase III randomized trial to compare the cycles of neoadjuvant chemotherapy using SOX for resectable locally advanced cancer. Based on a total of six to eight cycles of perioperative chemotherapy usually applied in locally advanced gastric cancer, patients in group A can be considered to have completed all perioperative chemotherapy, the results of which may suggest the feasibility of using chemotherapy only before surgery in gastric cancer.

Trial registration
Registered prospectively in the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) with registration number ChiCTR1900023293 on May 21st, 2019.
Randomized phase II study comparing the efficacy and safety of SOX versus mFOLFOX6 as neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer (KSCC1301)
Authors: Miwa Keisuke , Oki Eiji , Enomoto Masanobu , Ihara Keisuke , Ando Koji , Fujita Fumihiko , Tominaga Masahiro , Mori Shinichiro , Nakayama Goro , Shimokawa Mototsugu , Saeki Hiroshi , Baba Hideo , Mori Masaki , Akagi Yoshito 
Published: January 2021

Abstract
Background
Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadjuvant chemotherapy (NAC) regimens for LARC without RT.

Methods
Patients with untreated resectable LARC were randomly assigned to receive SOX or mFOLFOX6. The NAC protocol period was 3 months. The primary endpoint was 3-year disease-free survival (DFS), and the secondary endpoints included pathological effects, surgical completion rate, 3-year survival, and safety.

Results
From September 2013 to October 2015, 56 and 54 patients were enrolled in the SOX and mFOLFOX6 arms, respectively. The 3-year DFS rates were 69.4% (95% confidence interval [CI] 54.9–83.6) and 73.4% (95% CI 58.7–83.6) in the SOX and mFOLFOX6 arms, respectively; no significant differences were found between the arms (log-rank test; P = 0.5315, hazard ratio: 0.808, 95% CI 0.414–1.578). The 3-year survival rates were 92.3 and 91.8% in the SOX and mFOLFOX6 arms, respectively. The surgical completion rate was 98.1% overall, 100% in the SOX arm, and 96.0% in the mFOLFOX6 arm. The incidences of pathological response rates ≥grade 1b were 41.5 and 43.8% in the SOX and mFOLFOX6 arms, respectively. Both treatments were manageable and tolerable.

Conclusion
We demonstrated the effectiveness and safety of SOX and mFOLFOX6, both of which may be new neoadjuvant treatment candidates in previously untreated LARC cases.

Trial registration
Date of enrolment of the first participant to the trial: 3rd Oct 2013; This study was registered in the UMIN clinical trials registry on 14th Aug, 2013. (Prospectively registered, UMIN-CTR number UMIN000011486). https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&recptno=R000013441&language=J
The effects of social comparison and depressive mood on adolescent social decision-making
Authors: Hu Yixin , Zhou Mengmeng , Shao Yunru , Wei Jing , Li Zhenying , Xu Shike , Maguire Phil , Wang Dawei 
Published: January 2021

AbstractBackgroundBased on social comparison theory, two experiments were conducted to explore the effects of depression and social comparison on adolescents, using the ultimatum game (UG).MethodsBefore the formal experiment began, a preliminary experiment tested the effectiveness of social comparison settings. This study used the UG paradigm to explore adolescents’ social decision-making in the context of gain and loss through two experiments. These experiments were designed as a 2 (group: depressive mood group, normal mood group) × 2 (social comparison: upward, downward) × 3 (fairness level: fair 5:5, unfair 3:7, extremely unfair 1:9) three-factor hybrid study.Results(1) The fairer the proposal was, the higher the sense of fairness participants felt, and the higher their acceptance rate. (2) The acceptance rate of the participants for downward social comparison was significantly higher than that for upward social comparison, but there was no difference in fairness perception between the two social comparisons. (3) Under the context of gain, the acceptance rate of the depressive mood group was higher than that of the normal mood group, but there was no difference in the acceptance rate between the depressive mood group and the normal mood group under the loss context. Depressive mood participants had more feelings of unfairness in the contexts of both gain and loss. (4) The effects of depressive mood, social comparison and the fairness level of distribution on social decision-making interact.ConclusionsThe interaction of social comparison, depressive mood and proposal type demonstrates that besides one’s emotion, cognitive biases and social factors can also have an effect on social decision-making. These findings indicate that behavioral decision boosting may provide an avenue for appropriate interventions in helping to guide adolescents to make social decisions.
Family achievements in struggling with schizophrenia: life experiences in a qualitative content analysis study in Iran
Authors: Darban Fatemeh , Mehdipour- Rabori Roghayeh , Farokhzadian Jamileh , Nouhi Esmat , Sabzevari Sakineh 
Published: January 2021

Abstract
Background
The challenges of living with and taking care of a patient with schizophrenia can lead to positive changes depending on the experiences and reactions of family caregivers. Such changes may directly affect the family performance and the patient’s recovery stage. Present study aimed to explain the positive experiences reported by family caregivers of patients with schizophrenia.

Methods
The present study is a qualitative study of content analysis. Data were collected using semi-structured and in-depth interviews with 15 family caregivers of patients with schizophrenia referring to one of the psychiatric hospitals in Zahedan, Southeast part of Iran. Purposive sampling method was applied and data analysis was conducted using conventional content analysis proposed by Graneheim and Lundman.

Results
Data analysis created a theme entitled “family achievements in struggling with schizophrenia”. This theme included four categories including Developing positive personality traits in family members, Strengthening family ties, developing insight into the life, and social mobility.

Conclusions
The results provided insights that the experience of taking care of patients with schizophrenia led to positive consequences for family caregivers. Thus, it is recommended that psychiatrists or consultants help families rely on positive experiences and share these experiences with families with a newly-suffered patient.
A flexible short protocol in women with poor ovarian response over 40 years old
Authors: Zhang Xinyue , Feng Ting , Yang Jihong , Hao Yingying , Li Suying , Zhang Yan , Qian Yun 
Published: January 2021

AbstractBackgroundOvarian responsiveness to controlled ovarian stimulation is essential for a successful clinical outcome in assisted reproductive technology (ART) cycles. We aimed to find a suitable new ovulation stimulation protocol for poor ovarian response (POR) patients over 40 years old.MethodsA retrospective analysis of 488 ART cycles was evaluated from January 2015 to June 2019. Comparisons were made between the flexible short protocol (FSP), routine short protocol and mild stimulation protocol.ResultsCompared with the routine short protocol, the FSP delayed the gonadotropin start time and reduced the total gonadotropin dose per stimulation cycle. At the same time, compared with the mild stimulation protocol, the FSP improved oocyte quality and embryo quality and improved embryo implantation potential after transfer. Furthermore, the use of the FSP reduced the probability of premature ovulation, as it inhibited the premature luteinizing hormone (LH) surge to a certain extent.ConclusionsThe FSP yielded better outcomes than other protocols for patients with POR over 40 years old in our study. However, further prospective studies are needed to provide more substantial evidence and to determine whether the FSP can be successful for both patients over 40 years group and younger POR patients.