bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Affibody-Based Ultrasound Molecular Imaging of Vascular B7-H3 for Breast Cancer Detection
Authors: Bam Rakesh , Lown Patrick S. , Stern Lawrence A. , Sharma Karina , Wilson Katheryne E. , Bean Gregory R. , Lutz Amelie M. , Paulmurugan Ramasamy , Hackel Benjamin J. , Dahl Jeremy , Abou-Elkacem Lotfi 
Published: January 2020

Abstract

Purpose:
Human B7-H3 (hB7-H3) is a promising molecular imaging target differentially expressed on the neovasculature of breast cancer and has been validated for preclinical ultrasound (US) imaging with anti–B7-H3-antibody-functionalized microbubbles (MB). However, smaller ligands such as affibodies (ABY) are more suitable for the design of clinical-grade targeted MB.

Experimental Design:
Binding of ABYB7-H3 was confirmed with soluble and cell-surface B7-H3 by flow cytometry. MB were functionalized with ABYB7-H3 or anti–B7-H3-antibody (AbB7-H3). Control and targeted MB were tested for binding to hB7-H3–expressing cells (MS1hB7-H3) under shear stress conditions. US imaging was performed with MBABY-B7-H3 in an orthotopic mouse model of human MDA-MB-231 coimplanted with MS1hB7-H3 or control MS1WT cells and a transgenic mouse model of breast cancer development.

Results:
ABYB7-H3 specifically binds to MS1hB7-H3 and murine-B7-H3–expressing monocytes. MBABY-B7-H3 (8.5 ± 1.4 MB/cell) and MBAb-B7-H3 (9.8 ± 1.3 MB/cell) showed significantly higher (P &lt; 0.0001) binding to the MS1hB7-H3 cells compared with control MBNon-targeted (0.5 ± 0.1 MB/cell) under shear stress conditions. In vivo, MBABY-B7-H3 produced significantly higher (P &lt; 0.04) imaging signal in orthotopic tumors coengrafted with MS1hB7-H3 (8.4 ± 3.3 a.u.) compared with tumors with MS1WT cells (1.4 ± 1.0 a.u.). In the transgenic mouse tumors, MBABY-B7-H3 (9.6 ± 2.0 a.u.) produced higher (P &lt; 0.0002) imaging signal compared with MBNon-targeted (1.3 ± 0.3 a.u.), whereas MBABY-B7-H3 signal in normal mammary glands and tumors with B7-H3 blocking significantly reduced (P &lt; 0.02) imaging signal.

Conclusions:
MBABY-B7-H3 enhances B7-H3 molecular signal in breast tumors, improving cancer detection, while offering the advantages of a small size ligand and easier production for clinical imaging.
Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial
Authors: Rodriguez Gutierrez Daniel , Jones Chris , Varlet Pascale , Mackay Alan , Warren Daniel , Warmuth-Metz Monika , Aliaga Esther Sánchez , Calmon Raphael , Hargrave Darren R. , Cañete Adela , Massimino Maura , Azizi Amedeo A. , Le Deley Marie-Cécile , Saran Frank , Rousseau Raphael F. , Zahlmann Gudrun , Garcia Josep , Vassal Gilles , Grill Jacques , Morgan Paul S. , Jaspan Tim 
Published: January 2020

Abstract

Purpose:
The HERBY trial evaluated the benefit of the addition of the antiangiogenic agent Bevacizumab (BEV) to radiotherapy/temozolomide (RT/TMZ) in pediatric patients with newly diagnosed non-brainstem high-grade glioma (HGG). The work presented here aims to correlate imaging characteristics and outcome measures with pathologic and molecular data.

Experimental Design:
Radiological, pathologic, and molecular data were correlated with trial clinical information to retrospectively re-evaluate event-free survival (EFS) and overall survival (OS).

Results:
One-hundred thirteen patients were randomized to the RT/TMZ arm (n = 54) or the RT/TMZ+BEV (BEV arm; n = 59). The tumor arose in the cerebral hemispheres in 68 patients (Cerebral group) and a midline location in 45 cases (Midline group). Pathologic diagnosis was available in all cases and molecular data in 86 of 113. H3 K27M histone mutations were present in 23 of 32 Midline cases and H3 G34R/V mutations in 7 of 54 Cerebral cases. Total/near-total resection occurred in 44 of 68 (65%) Cerebral cases but in only 5 of 45 (11%) Midline cases (P &lt; 0.05). Leptomeningeal metastases (27 cases, 13 with subependymal spread) at relapse were more frequent in Midline (17/45) than in Cerebral tumors (10/68, P &lt; 0.05). Mean OS (14.1 months) and EFS (9.0 months) in Midline tumors were significantly lower than mean OS (20.7 months) and EFS (14.9 months) in Cerebral tumors (P &lt; 0.05). Pseudoprogression occurred in 8 of 111 (6.2%) cases.

Conclusions:
This study has shown that the poor outcome of midline tumors (compared with cerebral) may be related to (1) lesser surgical resection, (2) H3 K27M histone mutations, and (3) higher leptomeningeal dissemination.
Apresentação
Authors: Vicente Eduardo 
Published: January 2020

É com orgulho e alegria que apresentamos aos leitores mais uma edição da Novos Olhares. Graças ao apoio fundamental da Universidade de São Paulo, através do portal de revistas do Sistema Integrado de Bibliotecas, e à confiança e empenho de autores e pareceristas, temos conseguido manter aberto este espaço de partilha do conhecimento criado em 2007 pelo Prof. Dr. Mauro Wilton de Sousa e pelo Grupo de Estudos de Práticas de Recepção a Produtos Midiáticos.
Description of Cryptaphelenchus paravaricaudatus n. sp. (Aphelenchoidea: Ektaphelenchinae) from Pinus massoniana Lamb. in China
Authors: Pedram Majid , Gu Jianfeng , Liu Lele , Guo Kai 
Published: January 2020

Summary
Cryptaphelenchus paravaricaudatus n. sp., from declining Pinus massoniana in China, is described and illustrated. The new species is characterised by the 233-308 μm long females with distinctly annulated cuticle, lateral fields with four lines, lip region separated from the body by a shallow depression, delicate stylet with small knobs, post-vulval uterine sac short and rectum and anus invisible. Males are 204-259 μm long, with spicules 8.5-12.0 μm long, condylus well developed and broad, caudal papillae arranged as a single (P1) and a pair of precloacal papillae (P2) plus two pairs of postcloacal papillae (P3 and P4). Based upon the general morphology of the female, the new species most closely resembles C. varicaudatus. The morphological differences with the aforementioned species and other species having similar morphology are discussed. The phylogenetic analyses based on small (SSU) and large subunit (LSU) D2-D3 expansion segments of ribosomal DNA (rDNA) of different individuals of the new species revealed that it fell into the clade of Cryptaphelenchus in both SSU and LSU trees. The monophyly of the genus was retained.
The Hazaraspid Dynasty’s Legendary Kayanid Ancestry: the Flowering of Persian Literature under the Patronage of Local Rulers in the Late Il-khanid Period
Authors: Otsuka Osamu 
Published: January 2020

Abstract
This article discusses the flowering of Persian literature under the patronage of the Hazaraspid Nosrat al-Din, the local ruler of Lorestan in the late Il-khanid period. It is generally accepted that Persian literature evolved dramatically under the patronage of Mongol Il-khanid rulers. However, little research deals with the contribution of local rulers to this evolution. Persian literary works offered to Nosrat al-Din present him as a descendant of the legendary Kayanid kings and celebrate him as an ideal ruler who combined the characteristics of a Persian and an Islamic ruler. While accepting the suzerainty of the Il-khanids, Nosrat al-Din justified his power by emphasizing his identity as a Persian ruler by patronizing such cultural activities. This study presents a case where the growing awareness of a local ruler as a legitimate Persian ruler under Mongol domination contributed to the evolution of Persian literature at the time.
The Jalayirid Hidden King and the Unbelief of Shāh Mohammad Qara Qoyunlu
Authors: Binbaş Evrim 
Published: January 2020

Abstract
This article provides an account of the transfer of power from the Jalayirids to the Qara Qoyunlu in ʿErāq al-ʿArab (Iraq) and the religio-political history of the Qara Qoyunlu dynasty with a particular focus on the reign of Shāh Mohammad b. Qara Yusof, the Qara Qoyunlu ruler in Baghdad between 1411/814 and 1433/836. Contemporary historians accused Shāh Mohammad of unbelief and apostasy. The article argues that the reports on his conversion to Christianity might be an indication for the existence of a form of Islamic piety that involved the veneration of Jesus. Unlike the veneration of ʿAli b. Abi Tāleb and his descendants, the veneration of Jesus among the Turkmens of the fifteenth century is an understudied topic. This article is a contribution to the debate on the issue of the so-called “Turkmen religiosity,” which is often considered the wellspring of non-mainstream religious movements in the sixteenth and seventeenth centuries.
Observations Pertaining to Precipitation within the Northeast Pacific Stratocumulus-to-Cumulus Transition
Authors: Sarkar Mampi , Zuidema Paquita , Albrecht Bruce , Ghate Virendra , Jensen Jorgen , Mohrmann Johannes , Wood Robert 
Published: January 2020

Abstract
Three genuine stratocumulus-to-cumulus transitions sampled during the Cloud System Evolution over the Trades (CSET) campaign are documented. The focus is on Lagrangian evolution of in situ precipitation, thought to exceed radar/lidar retrieved values because of Mie scattering. Two of the three initial stratocumulus cases are pristine [cloud droplet number concentrations (Nd) of ~22 cm−3] but occupied boundary layers of different depths, while the third is polluted (Nd ~ 225 cm−3). Hourly satellite-derived cloud fraction along Lagrangian trajectories indicate that more quickly deepening boundary layers tend to transition faster, into more intense but more occasional precipitation. These transitions begin either in the morning or late afternoon, suggesting that preceding night processes can precondition or delay the inevitable transition. The precipitation shifts toward larger drop sizes throughout the transition as the boundary layers deepen, with aerosol concentrations only diminishing in two of the three cases. Ultraclean (Nd &lt; 1 cm−3) cumulus clouds evolved from pristine stratocumulus cloud with unusually high precipitation rates occupying a shallow, well-mixed boundary layer. Results from a simple one-dimensional evaporation model and from radar/lidar retrievals suggest subcloud evaporation likely increases throughout the transition. This, coupled with larger drop sizes capable of lowering the latent cooling profile, facilitates the transition to more surface-driven convection. The coassociation between boundary layer depth and precipitation does not provide definitive conclusions on the isolated effect of precipitation on the pace of the transition. Differences between the initial conditions of the three examples provide opportunities for further modeling studies.
Effects of kinesiotaping and exercise program on patients with obesity-induced coccydynia: a randomized, double-blinded, sham-controlled clinical trial
Authors: Abdel-Aal Nabil Mahmoud , Elgohary Hany Mohamed , Soliman Elsadat Saad , Waked Intsar Salem 
Published: January 2020

Objective: To investigate the effect of kinesiotaping and a designed exercise program versus sham kinesiotaping and the same exercise program on pain, range of motion, and activities of daily living in obese patients suffering from coccydynia. Design: A double-blinded, randomized, sham-controlled trial. Setting: Outpatient, Cairo University hospitals. Participants: Sixty patients with coccydynia randomized equally into kinesiotape plus exercise and sham kinesiotape plus exercise groups. Intervention: The kinesiotape was worn for three days and replaced for three weeks. Each patient practiced exercises for three weeks. Outcome measures: All patients were examined by visual analogue scale (VAS) for rating pain, Modified Modified Schober Test (MMST), and Oswestry Disability Index (ODI). All outcomes were measured at baseline, three weeks postintervention, and four weeks follow-up. Results: There were no statistically significant differences between groups at baseline ( P < 0.05), but there were statistically significant differences between groups for pain score, MMST, and ODI at post and follow-up data in favor of the kinesiotape group ( P < 0.001). For the three weeks postintervention, mean (SD) for pain score, MMST, and ODI was 33.07 ± 3.8, 6.6 ± 0.7, and 8.7 ± 2.1 in the study group and 39.9 ± 4.7, 5.8 ± 1.4, and 14.4 ± 2.7 in the control group, respectively. For the four weeks follow-up, mean (SD) for pain score, MMST, and ODI was 32.2 ± 3.4, 7.13 ± 0.6, and 7.2 ± 1.8 in the study group and 40.9 ± 4.4, 6.6 ± 0.75, and 13 ± 2 in the control group, respectively. Conclusion: Experimental kinesiotape intervention and exercise program provided significant improvements in pain, range of motion, and disability. It is suggested as an adjunctive therapy in treating obese patients with coccydynia.
The impact of surviving bowel cancer on occupation: A scoping review
Authors: Martin Elizabeth , Hocking Clare , Sandham Margaret 
Published: January 2020

Introduction The number of people surviving bowel cancer is increasing globally, with many of those affected living with long-term psychological and physical sequelae that potentially disrupt occupations. Method A scoping review – guided by Arksey and O’Malley’s methodological framework – was conducted to provide an overview of what is known about the impact of having had bowel cancer on occupations, and to reveal the potential role of occupational therapy. A systematic search of four databases and a grey literature repository generated 244 results. Applying inclusion and exclusion criteria, 33 items addressing bowel cancer and occupations were selected and thematically analysed. Results Researchers have identified six domains of occupation that are impacted by bowel cancer (social activity, physical activity, sexual activity, employment and role functioning, physical functioning, and self-care) but survivors report a distinct lack of health professional support after completion of medical treatment and being left to devise self-management strategies to accommodate the long-term effects of their cancer. Conclusion The sequelae of bowel cancer can have a significant impact on occupational participation. There is scope for increasing and improving occupational therapy input to assist people with cancer-related loss of function to re-engage in valued occupations and improve wellbeing.
Perception and Beliefs Regarding Cardiovascular Risk Factors and Lifestyle Modifications Among High-Risk College Students
Authors: Tran Dieu-My T. , Dingley Catherine , Arenas Rogelio 
Published: January 2020

Background Studying risk factors and corresponding behavior in young adults is important as atherosclerotic plaque begins to form in early adulthood, resulting in cardiovascular disease (CVD) later in life. The purpose of this study was to explore the perceptions and beliefs regarding cardiovascular risk and lifestyle modification among high-risk college students (based on Framingham 30-year risk score). Methods Semistructured qualitative interviews were conducted and analyzed using qualitative content analysis. Results Risk factors included overweight/obesity, alcohol consumption, elevated blood pressure, family history, and smoking. Qualitative interviews revealed six themes: (a) recognizing risk, (b) lifestyle trajectories, (c) factors influencing lifestyles, (d) ideal healthy lifestyle modifications, (e) perceived benefits of healthy lifestyles, and (f) integrating technology and health apps. Participants demonstrated a lack of understanding of how the various factors contributed to CV risk. Influencing factors to a healthy lifestyle were categorized as environmental, relational, financial, work/life/school balance, and internal/intrinsic motivation. Conclusions Understanding high-risk college students’ beliefs and perceptions regarding CVD risk factors and lifestyle modification is the first step to assessing the problem facilitating early intervention in the young adult population. Clinicians should assess, develop, and implement risk reduction programs that are tailored to individuals who need it the most, those at high risk.
Sex-Based Differences in Optimal Tunnel Placement for Acromioclavicular Joint Reconstruction
Authors: Benavent Kyra A. , Zhang Dafang , Matzkin Elizabeth G. , Earp Brandon E. 
Published: January 2020

Background: Tunnel placement is important for outcomes after acromioclavicular (AC) joint reconstruction, yet little has been written on sex-based differences in optimal tunnel positioning. Hypothesis: No sex-based or anatomic differences will be found in ideal tunnel position based on radiographic measurements. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The records of 2382 patients were retrospectively examined for clavicle radiographs over a 20-year period. A random set of radiographs were reviewed until 200 radiographs from each sex met inclusion criteria per a priori power analysis. Anteroposterior clavicle radiographs were used to collect (1) length from lateral clavicle to lateral coracoid (LCLC), (2) length from lateral clavicle to medial coracoid (LCMC), (3) clavicle length (CL), and (4) clavicular depth at the midcoracoid (MCCD). The Student t test was used to compare differences between male and female patients. The Pearson correlation coefficient was used to measure linear correlations. Variables with a P < .1 were included in a multiple regression model. Results: The cohort included 200 men and 200 women. LCLC and LCMC were significantly greater for men than for women ( P < .0001). Clavicle length was significantly correlated with LCLC ( r = 0.63; P < .0001) and LCMC ( r = 0.74; P < .0001). MCCD was significantly correlated with LCLC ( r = 0.32; P < .0001) and LCMC ( r = 0.43; P < .0001). The approximate placement for the trapezoid tunnel was found to be 22.1 mm in women and 26.6 mm in men. The approximate placement for the conoid tunnel was found to be 40 mm in women and 46.6 mm in men. The ratios (LCLC:CL and LCMC:CL) were also significantly different between female and male patients. The LCLC:CL was 0.144 in women and 0.154 in men ( P < .0001). The LCMC:CL was 0.261 in women and 0.271 in men ( P < .0006). Conclusion: Significant sex-based differences are found in the position of the coracoid relative to the lateral edge of the clavicle. Coracoid position relative to the lateral edge of the clavicle is correlated with anatomic parameters, most strongly with clavicle length.
Assessing the Patient Safety Culture in Dentistry
Authors: Yansane A. , Lee J.H. , Hebballi N. , Obadan-Udoh E. , White J. , Walji M. , Easterday C. , Rindal B. , Worley D. , Kalenderian E. 
Published: January 2020

Objectives: Medical errors are among the leading causes of death within the United States. Studies have shown that patients can be harmed while receiving care, sometimes resulting in permanent injury or, in extreme cases, death. To reduce the risk of patient safety incidents, it is imperative that a robust culture of safety be established. The primary objective of this study was to evaluate the patient safety culture among providers at 4 US dental institutions, comparing the results with their medical counterparts in 2016. Methods: This cross-sectional study uses the Medical Office Survey on Patient Safety Culture that was modified for dentistry and administered at 4 US dental institutions during the 2016 calendar year. All dental team members were invited to complete electronic or paper-based versions of the questionnaire. Results: Among 1,615 invited participants, 656 providers responded (rate, 40.6%). Medical institutions outperformed the dental institutions on 9 of the 10 safety culture dimensions, 6 of the 6 overall quality items, and 8 of the 9 patient safety and quality issues. The surveyed dental institutions reported the strongest average percentage positive scores in organizational learning (85%) and teamwork (79%). Conclusion: These findings suggest that the patient safety culture progressed over time. However, there is still heterogeneity within safety culture among academic dental, private (nonacademic), and medical clinics. Knowledge Transfer Statement: Patient safety is the first dimension of quality improvement. Administering the Medical Office Survey on Patient Safety Culture within dental clinics represents a key measure to understand where improvements can be made with respect to patient care safety.
Quantitative and Qualitative Analysis on Sex and Gender in Preparatory Material for National Medical Examination in Germany and the United States
Authors: Schluchter Helena , Nauman Ahmad T , Ludwig Sabine , Regitz-Zagrosek Vera , Seeland Ute 
Published: January 2020

Background: Sex- and gender-based medicine (SGBM) should be a mandatory part of medical education. We compared the quantity and quality of sex- and gender-related content of e-learning materials commonly used by German and American medical students while preparing for national medical examinations. Methods: Quantitative, line-by-line analysis of the preparatory materials AMBOSS 2017 and USMLE Step 1 Lecture Notes (2017) by KAPLAN MEDICAL was performed between April and October 2017. Subjects were allocated to one of the three main fields: clinical subjects, behavioral and social science, and pharmacology. Qualitative analysis comprised binary categorization into sex- and gender-based aspects and qualification with respect to the presence of a pathophysiological explanation for the sex or gender difference. Results: In relation to the total content of AMBOSS and KAPLAN, the sex- and gender-based share of the clinical subjects content was 26.8% (±8.2) in AMBOSS and 21.1% (±10.2) in KAPLAN. The number of sex- and gender-based aspects in the behavioral and social science learning material differed significantly for AMBOSS and KAPLAN (4.4% ± 3.1% vs 10.7% ± 7.5%; P = .044). Most of the sex- and gender-related content covered sex differences. Most learning cards and texts did not include a detailed pathophysiological explanation for sex- or gender-based aspects. The knowledge provided in the preparatory documents represents only a small part of facts that are already known about sex and gender differences. Conclusions: The preparatory materials focused almost exclusively on biological sex differences and the sociocultural dimension in particular is underrepresented. A lot more evidence-based facts are known and should be integrated into the materials to reflect the importance of SGBM as an integral component of patient-centered medicine.
The system Pd–Ag–S: phase relations and mineral assemblages
Authors: Vymazalová Anna , Laufek František , Kristavchuk Alexandr V. , Chareev Dmitriy A. 
Published: January 2020

AbstractPhase equilibria in the system Pd–Ag–S were studied using the silica-glass tube method at 400°C and 550°C. In the system we synthesised three ternary phases: coldwellite (Pd3Ag2S), kravtsovite (PdAg2S) and a new phase Pd13Ag3S4. At 400°С, coldwellite forms a stable association with vysotskite (PdS) and vasilite (Pd16S7); vysotskite and kravtsovite; phase Pd4S and a Ag–Pd alloy; it also coexists with a new phase Pd13Ag3S4. Kravtsovite is stable up to 507°C; the presence of kravtsovite in the mineral assemblage reflects its formation below this temperature. The occurrence of coldwellite, vysotskite and Ag2S together in equilibrium reflects the formation of this mineral assemblage above this temperature (507°C). Coldwellite is stable up at 940°С. Mineral assemblages defined in this study can be expected in Cu–Ni–PGE mineral deposits, associated with mafic and ultramafic igneous rocks, in particular in mineralisations with known silver–palladium sulfides.