bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroimages and Neuropathology of a Stroke-Like Cerebral Lymphomatoid Granulomatosis
Authors: Marano Massimo , Brunelli Chiara , De Marco Costanza , Martini Maurizio , Quattrocchi Carlo Cosimo , Lauriola Libero , Di Lazzaro Vincenzo 
Published: July 2020

A 70-year-old man presented to the Emergency Department reporting the acute onset of non-fluent aphasia, hyposthenia, and hemi-anesthesia of the right body. Brain computerized tomography revealed a subcortical hypodense lesion in the middle cerebral artery territory. Neck ultrasounds of internal and external carotid arteries and of the vertebral arteries showed a focal moderate stenosis of the left internal carotid artery due to a soft atheromasic plaque. These findings that were initially consistent with a diagnosis of an ischemic stroke were not confirmed by magnetic resonance (MR). The latter showed an hyperintense lesion on FLAIR and T2-weighted sequences located in the left centrum semiovale, corona radiata, and thalamus, with a well-defined regular rim and a mild compressive effect on the lateral ventricle, with diffusivity restriction but without ADC reduction and with a punctate and serpiginous gadolinium enhancement on T1 sequences (Figure 1). Within the first day of observation, the patient started complaining progressive mental deterioration, in absence of any other possible causes, and a total body CT scan excluded any other organ involvement. Patient was then referred to the neurosurgeon in order to perform a brain biopsy. The neuropathology was compatible with the diagnosis of cerebral lymphomatoid granulomatosis (LG) (Figure 1).
Overweight during lactation and its implications for biometric, nutritional and cardiovascular parameters of young and adult male and female rats
Authors: de Araújo Gracielle Amaral , Farias Raysa da Silva , Pedro Samuel de Sousa , Rocha Nazareth N. , Brito Fernanda C. F. , Scaramello Christianne B. V. 
Published: July 2020

Abstract
Litter size reduction can induce early overnourishment, being an attractive experimental model to study short- and long-term consequences of childhood obesity. Epidemiological data indicate sex differences regarding cardiometabolic disorders and hypertrophic cardiomyopathy. The present study aimed to describe biometric, nutritional and cardiovascular changes related to neonatal overweight promoted by litter size reduction in young and adult Wistar rats of both sexes. Litter adjustment to eight or four pups/mother (1:1 male-to-female ratio) gave, respectively, control and overweight groups. Body mass, food intake, haemodynamic and echocardiographic parameters and cardiorespiratory capacity were evaluated at postnatal days 30 and 150. Diminished litters were correlated with higher body mass and weight gain (12 %) during lactation, validating the experimental model of neonatal overweight. Soon after weaning male (16 %) and female (25 %) offspring of these litters presented a lower food intake than their respective control, without differences in body mass. Adult males from reduced litters presented higher abdominal circumference (7 %), systolic blood pressure (10 %), interventricular septum thickness (15 %) and relative wall thickness (15 %) compared with their respective control. Rats' performance on the maximal effort ergometer test was not affected by neonatal overweight. Data suggest the occurrence of catch-down growth and hypophagia in male and female rats submitted to neonatal overweight. However, only male rats presented haemodynamic and cardiac structural changes. These findings are crucial to personalised/gender medicine.
A duration estimator for a continuous time war of attrition game
Authors: Boehmke Frederick J. , Dion Douglas , Shipan Charles R. 
Published: July 2020

AbstractWe developed a maximum likelihood estimator corresponding to the predicted hazard rate that emerges from a continuous time game of incomplete information with a fixed time horizon (i.e., Kreps and Wilson, 1982, Journal of Economic Theory27, 253–279). Such games have been widely applied in economics and political science and involve two players engaged in a war of attrition contest over some prize that they both value. Each player can be either a strong or weak competitor. In the equilibrium of interest, strong players do not quit whereas weak players play a mixed strategy characterized by a hazard rate that increases up to an endogenous point in time, after which only strong players remain. The observed length of the contest can therefore be modeled as a mixture between two unobserved underlying durations: one that increases until it abruptly ends at an endogenous point in time and a second involving two strong players that continues indefinitely. We illustrate this estimator by studying the durations of Senate filibusters and international crises.
The “work” of being a bilingual: Exploring effects of forced language switching on language production and stress level in a real-world setting
Authors: Smith Sara A. , Seitz Stephanie R. , Koutnik Kelly H. , Mckenna Meaghan , Garcia Jorge N. 
Published: July 2020

AbstractResearch using single-word paradigms has established that forced language switching incurs processing costs for some bilinguals, yet, less research has addressed this phenomenon at the utterance level or considered real-world applications. The current study examined the impacts of forced language switching on spoken output and stress using a simulated virtual meeting. Twenty Spanish–English heritage bilinguals responded to general work-oriented questions in monolingual English (control) or language-switching (experimental) conditions. Responses were analyzed for mean length of utterance (MLU) and type-token-ratio (TTR). Multilevel modeling revealed an interaction effect of Condition (control vs. experimental) and question order on MLU, such that participants in the experimental condition produced significantly shorter utterances by the end of the task. Participants also had significantly lower lexical variation (TTR) overall in the experimental than the control condition. A 2 × 2 ANOVA revealed a significant effect of Condition and an interaction of Task (pre- vs. posttask) and Condition, such that participants in the control condition reported significantly lower stress after the activity. Results demonstrated the impact of a forced switching condition on production at the utterance level. Findings have implications for theory and scenarios in which heritage bilinguals are asked to use multiple languages in the workplace.
Variation and change in future temporal reference with avoir and être
Authors: Tristram Anna 
Published: July 2020

ABSTRACTVariation and change in the future temporal reference (FTR) sector in French has been the subject of numerous studies, from a variety of perspectives. Most studies consider the patterns of variation and evidence for change by looking at the verbal system as a whole. However, there are indications that some verbs differ significantly in their preference for one or other variant. Avoir and être are two such verbs. This study first examines the overall distribution of the inflected and periphrastic future with these two verbs in the ESLO corpus of spoken French, and considers the evidence for change. A multivariate analysis of the linguistic factors affecting variant selection in FTR with these two verbs reveals no exceptional effects; we thus explore other possible explanations for the exceptional distribution of FTR variants with these two verbs.
Assessing the Status of the Critically Endangered White-bellied HeronArdea insignisin north-east India
Authors: MENZIES ROHAN K. , RAO MEGHA , NANIWADEKAR ROHIT 
Published: July 2020

SummaryThe White-bellied HeronArdea insignisis currently known to be restricted to Bhutan, Myanmar, and north-east India. This ‘Critically Endangered’ species is under threat from the ever-changing river systems, primarily due to anthropogenic pressures including the large number of proposed hydropower projects. We report results of the first systematic, large-scale river survey for this species in the states of Arunachal Pradesh and Assam in north-east India with the aim of establishing its evidence-based distribution and assessing the severity of threats on the river systems in the region. We conducted river surveys along all seven major river basins in Arunachal Pradesh (October 2017–March 2018) and one in Assam (January 2019) along with 200 key informant surveys from 23 localities across the region. We encountered the White-bellied Heron six times in only three of 81 sites surveyed. Three interviewees reported observing the herons in three new localities, but we did not have a direct observation of the birds in any new sites. From field observations during the river surveys as well as the interview results, we found that certain fishing methods, garbage, and sand/gravel mining could be potential reasons for restricted occurrence of the White-bellied Heron in the region. Hunting is also a threat that prevails across the region. Our study calls for governmental commitment for the protection of the species and its vulnerable ecosystem and focussed research on understanding the anthropogenic impacts on the heron.
Highresolution X-Ray Spectroscopy at Room Temperature
Authors: Strüder L , Lechner P , Leutenegger P , Schülein T 
Published: July 2020

Abstract
Silicon drift detectors (SDD) have shown an excellent energy resolution close to room temperature. All signal charges, generated in the fully depleted volume by ionizing radiation are guided to a small electron collecting read-out node. The first amplification is realized with an integrated on-chip JFET. The total read-out capacitance can be kept below 250 fF, independent of the detector area. The fact, that the first amplifier is already integrated in the detector offers many operational advantages: (a) better resolution because of the reduction of read-node capacitance, (b) insensitivity with respect to acoustic noise and electrical pick-up, (c) compact detector packaging and (d) the absence of liquid nitrogen cooling. Fig. 1 shows the detector concept, including the integrated electronics. The X-rays are hitting the SDD from the homogeneous radiation entrance window on the backside of the device.
Secondary Electron Detectors, Image Quality & Contrast
Authors: Scharf David 
Published: July 2020

Abstract
The Secondary Electron Detector (SED) is the first link in the chain of image formation after the initial illumination of a specimen in a Scanning Electron Microscope (SEM), therefore it is most crucial that the efficiency of the SED be as great as possible in order to maximize Signal-to- Noise Ratio (S/N) as any imperfections, inadequacies, and noise are then amplified along with the signal by the subsequent electronic amplifiers in the signal chain.
In the Everhart-Thornley SED, matching the scintillator's output spectrum to the photomultiplier tube's photocathode spectral sensitivity is one factor along with other characteristics of the PM tube, like quantum efficiency and noise characteristics. Light-pipe material along with as optical coupling techniques are another factor which determines the overall efficiency of converting SE electron strikes on the scintillator to a video output signal.
An experimental study of the thermolysis of hydrogen cyanide: the role of hydrothermal systems in chemical evolution
Authors: Villafañe-Barajas Saúl A. , Colín-García María , Negrón-Mendoza Alicia , Ruiz-Bermejo Marta 
Published: July 2020

AbstractHydrogen cyanide (HCN) is considered a fundamental molecule in prebiotic chemistry experiments due to the fact that it could have an important role as raw material to form more complex molecules, as well as it could be an intermediate molecule in chemical reactions. However, the primitive scenarios in which this molecule might be available have been widely discussed. Hydrothermal systems have been considered as abiotic reactors and ideal niches for chemical evolution. Nevertheless, several experiments have shown that high temperatures and pressures could be adverse to the stability of organic molecules. Thus, it is necessary to carry out systematic experiments to study the synthesis, stability and fate of organic molecules in hydrothermal scenarios. In this work, we performed experiments focused on the stability and fate of HCN under a simple hydrothermal system scenario: the thermolysis of HCN at 100°C, at acidic and basic pH and in the presence of Mg-montmorillonite. Furthermore, we analysed the products from HCN thermolysis and highlighted the role of these chemical species as prebiotic molecules under a hydrothermal scenario.
Analysis of and Solution to the Polar Numerical Noise Within the Shallow‐Water Model on the Latitude‐Longitude Grid
Authors: Li Jianghao , Wang Bin , Dong Li 
Published: July 2020

AbstractThis study conducts an analysis of the polar numerical noise in the barotropic shallow‐water version of the Grid‐point Atmospheric Model of IAP LASG (GAMIL‐SW) and provides a good solution to the problem. GAMIL‐SW suffers from numerical noise in the polar region in some ideal test cases, which is likely to be detrimental to the full physical model. The noise is suspected to be related to the nonlinear advection term in the momentum equation. Thus, a new shallow‐water model with a vector‐invariant form of the momentum equation is developed on the latitude‐longitude grid to analyze the polar noise. It is found that the version with meridional wind component staggered on the pole is free from noise, while the version with zonal wind component staggered on the pole is still contaminated. By redefining the polar relative vorticity, the polar noise is eliminated in the latter version, and the global conservation properties are maintained. In addition, the test cases demonstrate that the new shallow‐water model maintains the properties of the original GAMIL‐SW with respect to numerical accuracy and computational stability. This study helps to identify appropriate governing equations to further develop the next generation of GAMIL dynamical core.
Depression, obesity and their comorbidity during pregnancy: effects on the offspring’s mental and physical health
Authors: Cattane Nadia , Räikkönen Katri , Anniverno Roberta , Mencacci Claudio , Riva Marco A. , Pariante Carmine M. , Cattaneo Annamaria 
Published: July 2020

AbstractDepression and obesity represent two of the most common complications during pregnancy and are associated with severe health risks for both the mother and the child. Although several studies have analysed the individual effects of depression or obesity on the mothers and their children, the effects associated with the co-occurrence of both disorders have so far been poorly investigated. The relationship between depression and obesity is very complex and it is still unclear whether maternal depression leads to obesity or vice versa. It is well known that the intrauterine environment plays an important role in mediating the effects of both depression and obesity in the mother on the fetal programming, increasing the child’s risk to develop negative outcomes.
CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils
Authors: Mao Zheying , Zhang Jiahui , Shi Yinghong , Li Wei , Shi Hui , Ji Runbi , Mao Fei , Qian Hui , Xu Wenrong , Zhang Xu 
Published: July 2020

AbstractDeregulated expression of chemokines in tumor microenvironment contributes to tumor metastasis by targeting distinct cells. Epithelial-derived neutrophil-activating peptide-78 (ENA78/CXCL5) is upregulated in many cancers and involved in tumor progression. The role and underlying mechanism of CXCL5 in gastric cancer (GC) metastasis remain unclear. In this study, we reported that the expression of CXCL5 was elevated in tumor tissues and positively associated with lymphatic metastasis and tumor differentiation. Stimulation by recombinant human CXCL5 (rhCXCL5) induced epithelial-mesenchymal transition (EMT) in GC cells through the activation of ERK pathway, which enhanced their migration and invasion abilities. The culture supernatant from tumor tissues also enhanced the migration and invasion abilities of GC cells, however, this effect was reversed by pre-treatment with CXCL5 neutralizing antibody. Further studies showed that rhCXCL5 could induce the expression of IL-6 and IL-23 in neutrophils through the activation of ERK and p38 signaling pathways, which in turn facilitated GC cell migration and invasion. The culture supernatant from tumor tissues showed similar effects on neutrophils in a CXCL5-dependent manner. Blockade of IL-6 and IL-23 with neutralizing antibodies reversed the induction of EMT and the increased migration and invasion abilities in GC cells by CXCL5-activated neutrophils. Moreover, CXCL5 activated neutrophils could promote gastric cancer metastasis in vivo. Taken together, our results indicate that CXCL5 acts on gastric cancer cells to induce EMT and mediates pro-tumor activation of neutrophils, which synergistically promotes the metastatic ability of GC cells.
TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression
Authors: Ni Zhen , Min Yali , Han Chuan , Yuan Ting , Lu Wenquan , Ashktorab Hassan , Smoot Duane T. , Wu Qiong , Wu Jian , Zeng Weizheng , Shi Yongquan 
Published: July 2020

AbstractIntestinal metaplasia (IM) increases the risk of gastric cancer. Our previous results indicated that bile acids (BAs) reflux promotes gastric IM development through kruppel-like factor 4 (KLF4) and caudal-type homeobox 2 (CDX2) activation. However, the underlying mechanisms remain largely elusive. Herein, we verified that secondary BAs responsive G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) was increased significantly in IM specimens. Moreover, TGR5 contributed to deoxycholic acid (DCA)-induced metaplastic phenotype through positively regulating KLF4 and CDX2 at transcriptional level. Then we employed PCR array and identified hepatocyte nuclear factor 4α (HNF4α) as a candidate mediator. Mechanically, DCA treatment could induce HNF4α expression through TGR5 and following ERK1/2 pathway activation. Furthermore, HNF4α mediated the effects of DCA treatment through directly regulating KLF4 and CDX2. Finally, high TGR5 levels were correlated with high HNF4α, KLF4, and CDX2 levels in IM tissues. These findings highlight the TGR5-ERK1/2-HNF4α axis during IM development in patients with BAs reflux, which may help to understand the mechanism underlying IM development and provide prospective strategies for IM treatment.
Field-induced resistance peak in a superconducting niobium thin film proximity coupled to a surface reconstructed SrTiO3
Authors: Singh Akhilesh Kr. , Kar Uddipta , Redell Matthew D. , Wu Tsung-Chi , Peng Wei-Hsiang , Das Bipul , Kumar Satish , Lee Wei-Cheng , Lee Wei-Li 
Published: July 2020

AbstractOxygen vacancy is known to play an important role for the physical properties in SrTiO3(STO)-based systems. On the surface, rich structural reconstructions had been reported owing to the oxygen vacancies, giving rise to metallic surface states and unusual surface phonon modes. More recently, an intriguing phenomenon of a huge superconducting transition temperature enhancement was discovered in a monolayer FeSe on STO substrate, where the surface reconstructed STO (SR-STO) may play a role. In this work, SR-STO substrates were prepared via thermal annealing in ultra-high vacuum followed by low energy electron diffraction analyses on surface structures. Thin Nb films with different thicknesses (d) were then deposited on the SR-STO. The detailed studies of the magnetotransport and superconducting property in the Al(1 nm)/Nb(d)/SR-STO samples revealed a large positive magnetoresistance and a pronounced resistance peak near the onset of the resistive superconducting transition in the presence of an in-plane field. Remarkably, the amplitude of the resistance peak increases with increasing fields, reaching a value of nearly 57% of the normal state resistance at 9 T. Such resistance peaks were absent in the control samples of Al(1 nm)/Nb(d)/STO and Al(1 nm)/Nb(d)/SiO2. Combining with DFT calculations for SR-STO, we attribute the resistance peak to the interface resistance from the proximity coupling of the superconducting niobium to the field-enhanced long-range magnetic order in SR-STO that arises from the spin-polarized in-gap states due to oxygen vacancies.
A benchmark dataset of protein antigens for antigenicity measurement
Authors: Qiu Tianyi , Qiu Jingxuan , Yang Yiyan , Zhang Lu , Mao Tiantian , Zhang Xiaoyan , Xu Jianqing , Cao Zhiwei 
Published: July 2020

AbstractAntigenicity measurement plays a fundamental role in vaccine design, which requires antigen selection from a large number of mutants. To augment traditional cross-reactivity experiments, computational approaches for predicting the antigenic distance between multiple protein antigens are highly valuable. The performance of in silico models relies heavily on large-scale benchmark datasets, which are scattered among public databases and published articles or reports. Here, we present the first benchmark dataset of protein antigens with experimental evidence to guide in silico antigenicity calculations. This dataset includes (1) standard haemagglutination-inhibition (HI) tests for 3,867 influenza A/H3N2 strain pairs, (2) standard HI tests for 559 influenza virus B strain pairs, and (3) neutralization titres derived from 1,073 Dengue virus strain pairs. All of these datasets were collated and annotated with experimentally validated antigenicity relationships as well as sequence information for the corresponding protein antigens. We anticipate that this work will provide a benchmark dataset for in silico antigenicity prediction that could be further used to assist in epidemic surveillance and therapeutic vaccine design for viruses with variable antigenicity.
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide
Authors: Luo Wen , Luo Ying , Yang Junqing 
Published: July 2020

AbstractNimesulide is an inhibitor of COX-2 with antioxidant and anti-inflammatory effects. However, few studies have explored the antidepressant mechanism of nimesulide. Here, we evaluated the therapeutic effects of nimesulide on CUMS rats. iTRAQ technology was used to identify the differentially expressed protein in the hippocampus between CUMS and nimesulide-treated rats to identify the possible molecular mechanism of its effects. We found that nimesulide had positive effects on depressive-like behaviors and inflammatory factors in depressed rats. Using proteomics technologies, we screened 16 differentially expressed proteins in CUMS-exposed rats after nimesulide treatment, 5 of which were related to inflammation. Overall, these results show that nimesulide might mediate its antidepressant effect on depressed rats through the inhibition of oxidative stress inflammatory response.