bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of guidelines for managing rheumatoid arthritis
Authors: Mian Aneela , Ibrahim Fowzia , Scott David L. 
Published: October 2019

Abstract

Background
We systematically reviewed current guidelines for managing rheumatoid arthritis (RA) to evaluate their range and nature, assess variations in their recommendations and highlight divergence in their perspectives.

Methods
We searched Medline and Embase databases using the terms ‘clinical practice guidelines’ and ‘rheumatoid arthritis’ from January 2000 to January 2017 together with publications of national and international bodies. We included guidelines providing recommendations on general RA management spanning a range of treatments and published in English. We undertook narrative assessments due to the heterogeneity of the guidelines.

Results
We identified 529 articles; 22 met our inclusion criteria. They were primarily developed by rheumatologists with variable involvement of patient and other experts. Three dealt with early RA, one established RA and 18 all patients. Most guidelines recommend regular assessments based on the Outcome Measures in Rheumatology core dataset; 18 recommended the disease activity score for 28 joints. Twenty recommended targeting remission; 16 suggested low disease activity as alternative. All guidelines recommend treating active RA; 13 made recommendations for moderate disease. The 21 guidelines considering early RA all recommended starting disease modifying drugs (DMARDs) as soon as possible; methotrexate was recommended for most patients. Nineteen recommended combination DMARDs when patients failed to respond fully to monotherapy and biologics were not necessarily indicated. Twenty made recommendations about biologics invariably suggesting their use after failing conventional DMARDs, particularly methotrexate. Most did not make specific recommendations about using one class of biologics preferentially. Eight recommended tapering biologics when patients achieved sustained good responses.

Conclusions
Five general principles transcend most guidelines: DMARDs should be started as soon as possible after the diagnosis; methotrexate is the best initial treatment; disease activity should be regularly monitored; give biologics to patients with persistently active disease who have already received methotrexate; remission or low disease activity are the preferred treatment target.
Insufficient lymph node assessment in gastric adenocarcinoma
Authors: Khanjani Nezhat , Mirzaei Sepideh , Nasrolahi Hamid , Hamedi Seyed Hasan , Mosalaei Ahmad , Omidvari Shapour , Ahmadloo Niloofar , Ansari Mansour , Sobhani Fatemeh , Mohammadianpanah Mohammad 
Published: October 2019

Abstract

Background
This study aimed to investigate the sufficient (≥ 16) lymph node assessment in 449 patients with gastric adenocarcinoma and literature review.

Methods
Four hundred and forty-nine patients with pathologically confirmed locoregional invasive gastric adenocarcinoma from 2004 to 2013 were included. A standard surgical resection was performed for all the patients with (n = 16) or without (n = 433) neoadjuvant treatment.

Results
In this study, 301 men and 148 women with a median age of 58 (range 21–88) years were included. The median total numbers of examined lymph nodes were 9 (range 0–55). Ninety-five patients (21.2%) had adequate (≥ 16) lymph node examination, and 70 patients (15.6%) had no examined lymph nodes. In univariate analysis, total or near total gastrectomy (P <  0.001), advanced node stage (P < 0.001), primary tumor size > 6 cm (P < 0.001), and the presence of perineural invasion (P = 0.039) were associated with more average number of examined lymph nodes. On multivariate analysis, node stage (P < 0.001) and type of surgery (P = 0.008) were independent predictive factors.

Conclusion
In this study, approximately one in five patients with gastric adenocarcinoma had sufficient lymph node assessment. More studies are suggested for identifying a true inadequate lymph node dissection from insufficient lymph node assessment.
PD-1 Blockade in Advanced Adrenocortical Carcinoma
Authors: Raj Nitya , Zheng Youyun , Kelly Virginia , Katz Seth S. , Chou Joanne , Do Richard K.G. , Capanu Marinela , Zamarin Dmitriy , Saltz Leonard B. , Ariyan Charlotte E. , Untch Brian R. , O'Reilly Eileen M. , Gopalan Anuradha , Berger Michael F. , Olino Kelly , Segal Neil H. , Reidy-Lagunes Diane L. 
Published: October 2019

PURPOSE Adrenocortical carcinomas (ACC) are rare and aggressive malignancies with limited treatment options. This study was undertaken to evaluate the immunogenicity of ACC. PATIENTS AND METHODS Patients with advanced ACC were enrolled in a phase II study to evaluate the clinical activity of pembrolizumab 200 mg every 3 weeks, without restriction on prior therapy. The primary end point was objective response rate. Efficacy was correlated with tumor programmed death-ligand 1 expression, microsatellite-high and/or mismatch repair deficient (MSI-H/MMR-D) status, and somatic and germline genomic correlates. RESULTS We enrolled 39 patients with advanced ACC and herein report after a median follow-up of 17.8 months (range, 5.4 months to 34.7 months). The objective response rate to pembrolizumab was 23% (nine patients; 95% CI, 11% to 39%), and the disease control rate was 52% (16 patients; 95% CI, 33% to 69%). The median duration of response was not reached (lower 95% CI, 4.1 months). Two of six patients with MSI-H/MMR-D tumors responded. The other seven patients with objective responses had microsatellite stable tumors. The median progression-free survival was 2.1 months (95% CI, 2.0 months to 10.7 months), and the median overall survival was 24.9 months (95% CI, 4.2 months to not reached). Thirteen percent of patients (n = 5) had treatment-related grade 3 or 4 adverse events. Tumor programmed death-ligand 1 expression and MSI-H/MMR-D status were not associated with objective response. CONCLUSION MSI-H/MMR-D tumors, for which pembrolizumab is a standard therapy, are more common in ACC than has been recognized. In advanced ACC that is microsatellite stable, pembrolizumab provided clinically meaningful and durable antitumor activity with a manageable safety profile.
Outcomes in Patients With Pancreatic Adenocarcinoma With Genetic Mutations in DNA Damage Response Pathways: Results From the Know Your Tumor Program
Authors: Pishvaian Michael J. , Blais Edik M. , Brody Jonathan R. , Rahib Lola , Lyons Emily , De Arbeloa Patricia , Hendifar Andrew , Mikhail Sameh , Chung Vincent , Sohal Davendra P.S. , Leslie Sam , Mason Kimberly , Tibbets Lisa , Madhavan Subha , Matrisian Lynn M. , Petricoin Emanuel 
Published: October 2019

PURPOSE Up to 25% of pancreatic adenocarcinomas (PDACs) harbor mutations in the homologous recombination DNA damage response (HR-DDR) pathway. Although known to affect responsiveness to DNA-damaging chemotherapy, the prognostic relevance of these mutations is unclear and outcomes in patients with PDAC who harbor HR-DDR mutations beyond BRCA1/2 remain unexplored. METHODS We evaluated 820 patients with PDAC enrolled in the Know Your Tumor program for whom we had collected comprehensive genomic testing results and longitudinal clinical outcomes. Patients were categorized as having resected versus advanced disease, and as having received platinum-based therapy versus being platinum naïve. Tumor genomic profiles were categorized as HR-DDR mutated (HR-DDRmut) or proficient (pHR-DDR) on the basis of the presence of pathogenic mutations of somatic or germline origin in BRCA1/2 or PALB2 (group 1); ATM/ATR/ATRX (group 2); or BAP1, BARD1, BRIP1, CHEK1/2, RAD50/51/51B, or FANCA/C/D2/E/F/G/L (group 3). Overall survival was measured from the date of diagnosis until death. RESULTS Median overall survival (mOS) was similar in all resected patients irrespective of exposure to platinum-based therapy, whereas for platinum-treated patients with advanced disease, mOS was significantly longer for HR-DDRmut versus pHR-DDR (2.37 years v 1.45 years, respectively). Of importance, no difference was identified in platinum-naïve patients. mOS in patients with mutations in all three HR-DDRmut groups was greater than that for pHR-DDR patients, but this difference was lost in platinum-naïve patients. CONCLUSION Patients with advanced HR-DDRmut have improved mOS when treated with platinum-based therapy compared with pHR-DDR patients. In platinum-naïve patients, there is no mOS difference, which suggests that HR-DDR status has no pure prognostic value. These findings support the need to test all patients with advanced PDAC to ensure that HR-DDRmut patients receive the benefit of treatment with platinum-based therapy.
Diagnostic Laparoscopy as a Selection Tool for Patients with Colorectal Peritoneal Metastases to Prevent a Non-therapeutic Laparotomy During Cytoreductive Surgery
Authors: Hentzen Judith E. K. R. , Constansia Reickly D. N. , Been Lukas B. , Hoogwater Frederik J. H. , van Ginkel Robert J. , van Dam Gooitzen M. , Hemmer Patrick H. J. , Kruijff Schelto 
Published: October 2019

Abstract

Objective
The aim of this study was to evaluate the introduction of diagnostic laparoscopy (DLS) in patients with colorectal peritoneal metastases (PM) to prevent non-therapeutic laparotomies during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC).

Methods
Patients with histologically proven colorectal PM who underwent a laparotomy for potential CRS + HIPEC from January 2006 to January 2019 were retrospectively identified from a prospectively maintained database. In 2012, DLS was introduced in the preoperative work-up for CRS + HIPEC in our academic center. The rates of non-therapeutic laparotomies, major postoperative complications (Clavien–Dindo grade III or higher), and survival outcomes were investigated for patients who underwent a laparotomy before (cohort A) and after (cohort B) the introduction of DLS. In cohort B, the reasons to refrain from DLS were retrospectively explored from medical records.

Results
Overall, 172 patients were included [cohort A: 48 patients (27.9%); cohort B: 124 patients (72.1%)]. A significant drop in the rate of non-therapeutic laparotomies occurred in cohort B compared with cohort A (21.0 vs. 35.4%: p = 0.044), despite only 85 patients (68.5%) from cohort B undergoing DLS in our academic center. The most important reason to refrain from DLS was a recently performed DLS or laparotomy in the referring hospital (48.7%). Major postoperative complications, in-hospital mortality, and survival outcomes were similar for both cohorts.

Conclusions
Performing DLS during the preoperative work-up for CRS + HIPEC prevents non-therapeutic laparotomies in patients with colorectal PM. We recommend performing this laparoscopic screening in an experienced HIPEC center.
HOUSTON, WE HAVE A (PHYSICAL ACTIVITY) PROBLEM
Authors: Peterman James E. , Bassett David R. 
Published: October 2019

Apply It!Summary Statement:Pulled Text:
• Physical activity is associated with several health and well-being benefits, but current levels of daily physical activity are at an all-time low.
• Daily physical activity has decreased over the years due to declining lifestyle physical activity levels.
• Innovative strategies from health and fitness professionals are needed to promote physical activity throughout the day.
Physical activity is associated with several health and well-being benefits but has decreased over the years due to declining rates of lifestyle physical activity.
“Despite these well-known benefits of physical activity though, there has still been a gradual decline in overall daily physical activity levels.”
“Various devices/appliances have been invented that reduce the physical activity associated with performing household chores. For example, sweeping requires moderate-intensity physical activity but can now be replaced with an autonomous robotic vacuum cleaner (e.g., the ‘Roomba’).”
Performing these tasks without modern technology, Amish adults accumulate an average of 48 hours per week of moderate- to vigorous-intensity physical activity (14).
Model-Based Prediction of Dissolved Oxygen Content in Fish Production
Authors: Zhu Nanyang , Xia Qian , Tan Jinglu , Jiang Yongnian , Xu Guanhua , Chu Dan , Guo Ya 
Published: October 2019

Abstract. Dissolved oxygen (DO) plays a vital role in fish production, but DO sensors are expensive and often malfunction as a result of corrosion and deposition of debris. In this work, polynomial regression, back-propagation neural network (BPNN), and long short-term memory (LSTM) were applied to develop models for estimation of DO from non-DO measurements in fish production. The root mean square error (RMSE), mean absolute percentage error (MAPE), coefficient of determination (R2), index of agreement (d), and Nash-Sutcliffe efficiency coefficient (NSE) were used to measure the performance of the three models. The results showed that the LSTM model achieved the best performance. A trained LSTM model can be used to estimate DO from water pH, temperature, and turbidity without using DO sensors. The estimated DO values can be used as a warning signal for DO sensor maintenance and as estimates of compromised DO measurements in fish production. HighlightsPrediction models were developed to estimate dissolved oxygen (DO) and their performance.The LSTM model achieved the best performance and can be used to estimate DO without using DO sensors.The estimated DO can be used as a warning signal for DO sensor malfunction and maintenance.The estimated DO can also be used to correct compromised DO measurements. Keywords: BP neural network, Dissolved oxygen, Long short-term memory, Polynomial regression, Principal component analysis.
Volba řešitelských strategií v závislosti na věku
Authors: Eisenmann Petr , Přibyl Jiří , Novotná Jarmila , Břehovský Jiří , Cihlář Jiří 
Published: October 2019

Příspěvek popisuje experiment, který byl součástí dlouhodobého výzkumu Rozvíjení kultury řešení matematických problémů ve školské praxi. Experiment byl proveden na vzorku celkem 584 respondentů ve věku 11–17 let a mapuje vývoj ve volbě řešitelských strategií matematických úloh u různých věkových skupin žáků. Žákům 6. a 8. ročníku základní školy, I. a III. ročníku střední školy byly předloženy tři úlohy, které se dají efektivně řešit pomocí heuristických strategií. Kromě úspěšnosti řešení úloh byla věnována pozornost také způsobu jejich řešení. Výsledkem experimentu je zjištění, že existují heuristické strategie, které žáci použili při řešení úloh i přesto, že s nimi ve výuce nebyli seznámeni. U některých z nich se jejich výskyt nemění v závislosti na věku.
The crystal structure of 3,5-dicarboxybenzenaminium perchlorate monohydrate, C8H8ClNO9
Authors: Cai Bin , Li Shu-Jing , Zhu Meng-En , Li Meng-Qi , Meng Yuning 
Published: October 2019

Abstract
C8H8ClNO9, monoclinic, P21/n (no. 14), a = 7.1284(3) Å, b = 8.5538(5) Å, c = 18.7089(10) Å, β = 99.760(2)°, V = 1124.26(10) Å3, Z = 4, Rgt(F) = 0.0381, wRref(F2) = 0.1031, T = 150 K.
The crystal structure of 2,4,6-tris[4-(1H-imidazol-1-yl)phenyl]-1,3,5-triazine — dimethylformamide (1/1), C33H28N10O
Authors: Cui Hao , Yan Xin-Ting , Chen Wenya , Yang Tao 
Published: October 2019

Abstract
C33H28N10O, triclinic, P1̄ (no. 2), a = 14.7148(9) Å, b = 15.5185(10) Å, c = 16.1128(9) Å, α = 113.219(6)°, β = 96.735(5)°, γ = 115.259(6)°, V = 2872.0(3) Å3, Z = 4, R
gt(F) = 0.0426, wR
ref(F
2) = 0.1108, T = 150(2) K.
Crystal structure of 8-hydroxy-2-methylquinolin-1-ium chloride dihydrate, C10H14ClNO3
Authors: Lo Kong Mun , Lee See Mun , Tiekink Edward R.T. 
Published: October 2019

Abstract
C10H14ClNO3, monoclinic, P21/c (no. 14), a = 7.2706(2) Å, b = 14.8440(5) Å, c = 10.3910(3) Å, β = 101.101(2)°, V = 1100.46(6) Å3, Z = 4, R
gt(F) = 0.0268, wR
ref(F
2) = 0.0735, T = 100(2) K.
Asimetrías de CP en Mesones B y Física Nueva
Authors: Delepine David , Ramirez Carlos A. , Jaramillo Avila Benjamín Raziel 
Published: October 2019

La colaboración BELLE reporto violación de CP (C, conjugación de carga y P, paridad) en decaimientos directos de mesones B en mesones K y piones. Pero las asimetrías de CP medidas en el decaimiento del y en el decaimiento delresultan muy diferentes una del otro cuando se esperaría a dentro del modelo que unifica las interacciones electromagnéticas, débiles y fuertes que las asimetrías de CP deberían tener el mismo signo y un valor muy cercana. En este trabajo, se estudia cómo se tiene que modificar el modelo estándar de las interacciones fundamentales para explicar las observaciones de BELLE. Nuestro análisis es modelo-independiente. Y demostramos que no se puede reproducir los resultados de BELLE solamente modificando la fase de los coeficientes de Wilson que describen esos procesos.
El Nopal fresco como fuente de fibra y calcio en panqués
Authors: Bautista-Justo Mayela , Pineda Torres Rosa Inés , Camarena-Aguilar Ernesto , Alanís- Guzmán Guadalupe , Da Mota Victor Manuel , Barboza- Corona José Eleazar 
Published: October 2019

El objetivo de este trabajo fue utilizar nopal fresco en la formulación de panqués para incrementar su contenido de fibra dietética y calcio. Se desarrollaron cinco formulaciones de panqués utilizando nopal fresco (Opuntia amyclaea Tenore), 4 con sucralosa (una testigo sin nopal) y una con azúcar y nopal. Se evaluaron sensorialmente por 60 jueces no entrenados mediante la prueba de preferencia, utilizando una escala hedónica del 1 al 9. Se les determinó el contenido de proteína (Nx6.25), humedad, cenizas, lípidos, hidratos de carbono, fibra dietética total, calcio y fósforo por los métodos de la AOAC, (1990). Los resultados revelaron contenidos de proteínas (Nx6.25) entre 9.54 y 10.08, de humedad entre 35.75 y 40.00, de cenizas, 2.29 g/100 g y 2.44 g/100 g peso húmedo. La evaluación sensorial mostró una buena aceptación, los contenidos de fibra dietética total estuvieron entre 8.27 % y 10.43 % y los de calcio entre 0.27 y 0.375 g/100 g. El valor calórico fue de 216.02 kcal a 225.68 kcal kJ/100 g de panqué, aproximadamente 50 % menos que los que se ofrecen en el mercado. Por su alto contenido de fibra y calcio, ausencia de azúcar y bajo valor calórico estos productos podrían ser una opción saludable para personas diabéticas y obesas.
Effect of Short-Term Aging on Wax-Modified Crumb Rubber Binder Based on Rutting Performance and Chemical Characterization
Authors: Kataware Aniket Vasantrao , Singh Dharamveer 
Published: October 2019

Abstract
Waste tires are processed to modify asphalt binders. Asphalt pavement constructed using crumb rubber modified (CRM) binders have shown good rutting and fatigue performance. However, the use of CRM involves high construction temperature. High temperature leads to aging and successive degradation of CRM binders and also causes significant emission of greenhouse gases. To address this concern, Fischer-Tropsch (FT) wax-based warm mix additive has been used in the present study. CRM binder was modified using three dosages (1 %, 2 %, and 3 % by weight of asphalt binder) of FT additive. CRM binder and CRM binder with FT additive were short-term aged (STA) at 163°C and 143°C, respectively, using a thin-film oven. To evaluate the effect of FT modification on aging susceptibility of CRM binder, physical and chemical properties of CRM binder with and without FT additives were examined. CRM binders with and without FT additives were evaluated in unaged and STA conditions using physical (multiple stress creep recovery [MSCR] test to assess rutting performance) and chemical characterization (Fourier transform infrared [FTIR] spectroscopy test to assess change in chemical compounds/groups). Based on MSCR parameters, FT modification improved rut resistant, elastic performance, and ranking of CRM binder in unaged and STA conditions. On the other hand, FT modified CRM binders were observed to be more temperature susceptible and more stress sensitive as compared to the control CRM. FTIR results showed an increase in absorption values of Carbon-Hydrogen (C-H) long chain, C-H methyl rocks, and carbonyl compound of CRM binder after FT modification. Also, the absorption values of FTIR functional groups were found to be directly proportional to R and inversely proportional to Jnr values of CRM binders with and without FT additive in unaged and STA conditions at tested temperatures. Considering aging sensitivity, FT modified CRM binders were less prone to aging. Therefore, FT additive modification improved rut resistant performance as well as worked as an antioxidant for CRM binder.
The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach
Authors: Voliotis Margaritis , Li Xiao Feng , De Burgh Ross , Lass Geffen , Lightman Stafford L. , O'Byrne Kevin T. , Tsaneva-Atanasova Krasimira 
Published: October 2019

Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoinin-B and dynorphin. Here, using mathematical modeling andin vivooptogenetics we reveal for the first time how this neural construct initiates and sustains the appropriate ultradian frequency essential for reproduction. Prompted by mathematical modeling, we show experimentally using female estrous mice that robust pulsatile release of luteinizing hormone, a proxy for GnRH, emerges abruptly as we increase the basal activity of the neuronal network using continuous low-frequency optogenetic stimulation. Further increase in basal activity markedly increases pulse frequency and eventually leads to pulse termination. Additional model predictions that pulsatile dynamics emerge from nonlinear positive and negative feedback interactions mediated through neurokinin-B and dynorphin signaling respectively are confirmed neuropharmacologically. Our results shed light on the long-elusive GnRH pulse generator offering new horizons for reproductive health and wellbeing.SIGNIFICANCE STATEMENTThe gonadotropin-releasing hormone (GnRH) pulse generator controls the pulsatile secretion of the gonadotropic hormones LH and FSH and is critical for fertility. The hypothalamic arcuate kisspeptin neurons are thought to represent the GnRH pulse generator, since their oscillatory activity is coincident with LH pulses in the blood; a proxy for GnRH pulses. However, the mechanisms underlying GnRH pulse generation remain elusive. We developed a mathematical model of the kisspeptin neuronal network and confirmed its predictions experimentally, showing how LH secretion is frequency-modulated as we increase the basal activity of the arcuate kisspeptin neuronsin vivousing continuous optogenetic stimulation. Our model provides a quantitative framework for understanding the reproductive neuroendocrine system and opens new horizons for fertility regulation.
3D echocardiography allows rapid and accurate surgical planning in complex aortic root abscess cases
Authors: Ahluwalia Viren , Osman Faizel , Parmar Jitendra , Khan Jamal Nasir 
Published: October 2019

Summary
Despite 3D echocardiography (3DE) acquiring significantly greater data than standard 2D echocardiography (2DE), it is underutilised in assessing cardiac anatomy and physiology. A key advantage is the ability of a single 3DE acquisition to be post-processed to generate volume-rendered 3D models and an unlimited number of multiplanar reconstruction (MPR) images. We describe the case of a highly anxious patient with life-threatening complex aortic valve endocarditis and aortic root abscess, refusing transesophageal echocardiography (TOE) under general anaesthesia with tachycardia, breathlessness and acute kidney injury precluding accurate or safe gated (computed tomography) CT, who was comprehensively assessed with a rapid 3D-TOE under sedation. This led to timely surgery and an excellent outcome for the patient.