bluuebunny/crossref_metadata_2025_split huggingface dataset:
Original Article Non-Hematological Malignancies Seeding in Bone Marrow
Authors: Gahlot Gaurav PS , Ahuja Ankur , Baranwal Ajay Kumar , Madhukar Gunjan , Asthana Bhushan , Chatterjee Tathagata , Sahai Kavita 
Published: November 2020

Background: Bone marrow is the site of origin for primary haematological malignancies and is the third common preferred site metastasized by the solid tumors. The malignant infiltration of the hematopoietic tissue alters the clinical course of disease, response of the treatment and influences the overall survival. The aim of this study was to assess pattern of bone marrow involvement by different solid tumors and their correlation with hematological parameters.
Methods: In this retrospective study, 8064 bone marrow examinations from Jan 2011-Aug 2017 at tertiary health and research centre of Northern India were evaluated to access spectrum of different solid tumors infiltrating the bone marrow alongwith their clinical, hematological and histopathological findings.
Result: Total 38 cases of non-hematological malignancies metastasizing to bone marrow were evaluated with main indications of lytic lesions, cytopenia and Pyrexia of Unknown Origin. The most common metastasis were adenocarcinoma of prostate and lung. In 33 cases, the clinical, cytomorphological and immunohistochemical analysis findings were correlated to know primary site, while in remaining five patients, even after complete diagnostic evaluation, the definitive origin could not be ascertained, therefore categorized as Carcinoma of Unknown Primary Site (CUPS).
Conclusion: Our series showed that anemia as commonest parameter, followed by leukopenia, thrombocytopenia. Many cases were misdiagnosed as multiple myeloma due to lytic lesion, anemia and hypercalcemia. We concluded that unexplained cytopenia are strong indicators of bone marrow examination; an easy, convenient, sensitive, effective procedure of staging of tumor, monitoring the course and prognosis of solid tumors.
Histomorphological Spectrum of Renal diseases: A Prospective Study for A Period of Two Years
Authors: N Deepthi K , Karamchedu Shilpa , . Apurva 
Published: November 2020

INTRODUCTION: Kidneys are vital organs of the body with multiple functions like excretory, acid base balance and maintenance of blood pressure. Renal parenchyma is mostly subjected to noxious insults but is last to respond. Simple nephrectomy is done for irreversibly damaged kidney. Most common indication for nephrectomy is chronic pyelonephritis. Aim of the study is to analyze the histopathological patterns of renal lesions and to analyze age and sex distribution.
MATERIALS AND METHODS: The study included a total number of 70 cases, during a period of 2 years i.e., from October 2017 to September 2019. All renal biopsies and nephrectomy specimens received in pathology department, SVS Medical College, Mahabubnagar, Telangana, India were included in the study.
RESULTS: In our study, 70 cases were analyzed. Out of which majority of the lesions (25.7 % ) were in the age group of 21-40 years and showed male preponderance (68.5 %). Present study showed chronic pyelonephritis being the most common non-neoplastic lesion. Among malignant tumors renal cell carcinoma was most common.
CONCLUSION: The present study reveals various histological patterns of lesions in renal biopsies and nephrectomy specimens. Our study reveals that non-neoplastic lesions are more commonly encountered lesions.
DLBCL of Clavicle: Role of FNA in diagnosis of Rare Lesion
Authors: Jokhi Cyrus Dara , Vaghela Kalpesh V , Damor Pruthvi 
Published: November 2020

Primary bone lymphoma is rare, among which commonly involved site at time of presentation are femur, pelvic bones, tibia and most common type is Large B cell lymphoma which usually occurs in adults. Cases of large B cell lymphoma in clavicle as primary bone lymphoma is extremely rare finding. According to our knowledge this case may be first reported case of world. We are here reporting a case of 62-year female presented as sternoclavicular joint swelling, without fever or pain in local area. Patient was diagnosed on X ray by radiologist, as well as by clinician as, osteosarcoma of right clavicle. Patient came to Department of Cytopathology for FNA for confirmation of X ray finding. On FNA diagnosis of Non-Hodgkin lymphoma was given, and advise for biopsy and immunohistochemistry (IHC) was given for confirmation of diagnosis and to subtype NHL. On IHC Ki67 index was 85%, with diffuse positivity noted for MUM1, CD79a, and CD138 along with cytoplasmic positivity for ALK 1 and patchy positivity for PAX 5. Tumor was negative for BCL6, BCL2, CD20, CD5, CD23, CD10, CD19, CD4, CD8, CD7, CD3. Diagnosis of ALK positive DLBCL was given on biopsy after IHC. Patients with PBL treated with combined modality were found to have a superior outcome, with a significantly better survival (5-year cause-specific survival 95%). So correct and timely pathological diagnosis of DLBCL as PBL is significantly important for prognosis.
Spinal Space Occupying Lesions: A Comprehensive Study of Clinico-pathological Spectrum and Measure of Degree of Agreement Between the Diagnostic Modalities
Authors: Gubbala Srinivas DD , Mattaparti Sridevi , . Bhavani 
Published: November 2020

Back ground: Spinal SOLs are quite fascinating group of lesions, comprising a minority of central nervous system lesions often resulting in significant morbidity. There is paucity of comprehensive population-based data of these SOLs in Indian subcontinent.

Material and methods: The present study was a retrospective descriptive study conducted at the department of pathology, Kamineni Institute of Medical Sciences for 3 years starting from January 2017 to December 2019.

Results: We analyzed eighty-nine spinal SOLs during the study period. Spinal neoplasms encompassed the largest number accounting for 70.7% of total spinal SOLs. Majority were reported in the 20-40 years’ age group with predominant male preponderance except for universal phenomenon of female predominance in meningioma. Back pain was the most common clinical presentation. Among spinal neoplasms, NSTs comprising of schwannoma and neurofibroma, was the most common finding and spinal tuberculosis was the most common non-neoplastic SOL. Majority of benign spinal tumors were distributed in the intradural extra medullary location and involved thoracic vertebrae. Malignant tumors predominantly involved extradural location and were clustered along thoracic and lumbar vertebrae. Measure of agreement between radiological and histopathological diagnosis using kappa statistics revealed almost perfect agreement for extradural spinal SOLs and moderate agreement for intradural intramedullary and intradural extra medullary SOLs.

Conclusion: Comprehensive evaluation of spinal SOLs warrants multidisciplinary approach. Rapid advancements in radiology optimised diagnostic evaluation of non-neoplastic SOLs, however we conclude that histopathological evaluation is still the gold standard for diagnosis of primary spinal cord tumours and for planning the treatment and predicting prognosis.
Clinical Term Normalization Using Learned Edit Patterns and Subconcept Matching: System Development and Evaluation
Authors: Kate Rohit J 
Published: November 2020

Background
Clinical terms mentioned in clinical text are often not in their standardized forms as listed in clinical terminologies because of linguistic and stylistic variations. However, many automated downstream applications require clinical terms mapped to their corresponding concepts in clinical terminologies, thus necessitating the task of clinical term normalization.

Objective
In this paper, a system for clinical term normalization is presented that utilizes edit patterns to convert clinical terms into their normalized forms.

Methods
The edit patterns are automatically learned from the Unified Medical Language System (UMLS) Metathesaurus as well as from the given training data. The edit patterns are generalized sequences of edits that are derived from edit distance computations. The edit patterns are both character based as well as word based and are learned separately for different semantic types. In addition to these edit patterns, the system also normalizes clinical terms through the subconcepts mentioned within them.

Results
The system was evaluated as part of the 2019 n2c2 Track 3 shared task of clinical term normalization. It obtained 80.79% accuracy on the standard test data. This paper includes ablation studies to evaluate the contributions of different components of the system. A challenging part of the task was disambiguation when a clinical term could be normalized to multiple concepts.

Conclusions
The learned edit patterns led the system to perform well on the normalization task. Given that the system is based on patterns, it is human interpretable and is also capable of giving insights about common variations of clinical terms mentioned in clinical text that are different from their standardized forms.
THE ROLE OF CANNABIDIOL IN THE INFLAMMATORY PROCESS AND ITS PROPERTIES AS AN ALTERNATIVE THERAPY – A REVIEW (META-ANALYSIS)
Authors: M FERRO , P ESCALANTE , A GRAUBARD 
Published: November 2020

Abstract
Cannabis has been used as a medicinal plant for thousands of years in Asia. Numerous physical, psychological, and emotional benefits have been attributed to cannabis since its first reported use in 2,600 BC in a Chinese pharmacopoeia. Recent years have seen a resurgence in interest in the therapeutic potential of compounds derived from these plants, mainly the non-psychoactive compound cannabidiol (CBD). In this way, we seek to evaluate, through this present study, what has been published about CBD in the Pubmed / Medline database in the last two years (2019/2020) in relation to anxiety, depression, panic attack and dementia, as well as therapeutic dosages, results with significant values, side effects and others reported in the studies found. The results were distributed in 4 tables. In the first, the types of publication were reported; in the second, the proposal for evaluation; in the third, the results with significance evaluated; and in the fourth the doses used. Although the majority of studies found are in the form of a review (55.3%), several studies in humans have shown promising results with the use of CBD in therapies. The treatments for anxiety and stress with CBD were the most evident accounting for 37.8% of the total studies found in table 2. The relationship of CBD in metabolic processes as inflammatory markers, activator of specific nuclear receptors and protein modulations was the second most evident item na tabela 2 with 11,1%. Cognitive processes and depression appear comes in sequence with 8.9% both. The results of significance values found in this study demonstrated a good acceptance in the treatment with CBD regarding anxiety and stress. With 70.6% of positive results in table 3, CBD appears as a promising option in the treatment of anxiety, stress and similar behaviors. Regarding depression, the results were slightly lower. With 66.6% positive results, depression can also be treated with CBD as an alternative therapy option. In dose used CBD administration are extremely diverse. The doses ranged from 25mg to 800mg depending on the time of administration and also the purpose of the therapy. Although the results presented in this study are promising, we need more information to be able to position ourselves on the efficiency of CBD in proposed treatments.
STUDY LITERATION OF CHEMICAL CONTENTS OF SOME PLANTS THAT POTENTIALLY AS THE SOLAR SOWS
Authors: S Sukmawati , Kaswan Dwi Rizka Sari , Pratama Mamat 
Published: November 2020

Excessive sun exposure causes the epidermal tissue of the skin to be unable to fight negative effects such as skin disorders ranging from mild dermatitis to skin cancer, so skin protection is needed such as the use of sunscreen, many plants in Indonesia contain phenolic and flavonoid contents that can potentially act as sunscreens. This study aims to determine the chemical content of several plants that have potential as sunscreen. Where this research was conducted through data collection from several scientific research journals. The data collection is done online using Google, Google Scholar. Based on the data obtained from several scientific research journals, it can be stated that some plants have the potential to act as sunscreens, by looking at the content they have, namely phenolic and flavonoids. The ethanol extract of 96% of Sembung Rambat Plants (Mikania micrantha Kunth) with an SPF value of 42.8810 with a total flavanoid content of 1.175%.
Peer Review History:
Received: 10 September 2020; Revised: 15 October; Accepted: 23 October, Available online: 15 November 2020
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
Received file

Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewer(s) detail:
Ahmad Najib, Department of Pharmacognosy-Phytochemystry Universitas Muslim Indonesia-Indonesia, ahmad.najib@umi.ac.id
Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com
Dr. Mohamed Said Fathy Al-Refaey, University of Sadat City, Menofia, Egypt, mido_ph212@yahoo.com
Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com
Comments of reviewer(s):

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MOTIVASI ATLET CLUB RENANG DI KABUPATEN BADUNG DALAM MENJAGA KEBUGARAN JASMANI PADA MASA PANDEMI COVID-19
Authors: Yasa Putu Putra , Artanayasa, Dr. I Wayan 
Published: November 2020

Penelitian ini bertujuan untuk mengetahui motivasi atlet club renang di kabupaten Badung dalam menjaga kebugaran jasmani pada masa pandemi covid-19. Jenis penelitian ini merupakan penelitian deskriptif kuantitatif dengan jenis survei. Populasi pada penelitian ini adalah Bali Pari Swimming Club, Bali Pari Fins Swimming Club, Taman Tirta Swimming Club dengan jumlah 128 orang, dan sampel pada penelitian ini adalah 25% dari populasi yaitu berjumlah 32 orang. Pengambilan sampel menggunakan non random sampling yaitu quota sampling. Analisis data menggunakan statistik deskriptif kuantitatif dengan katagori interval. Hasil dari penelitian motivasi atlet club renang di kabupaten Badung dalam menjaga kebugaran jasmani pada masa pandemi covid-19 pada faktor intrinsik yaitu 83 dan pada faktor ekstrinsik mendapat skor 81. Dari kedua faktor tersebut motivasi atlet club renang di Kabupaten Badung dalam menjaga kebugaran jasmani pada masa pandemi covid-19 mendapat skor 82 dalam sekala penelitian katagori sangat tinggi. Saran dari peneliti untuk atlet agar menjadi lebih termotivasi dalam menjaga kebugaran jasmani meskipun ditengah pandemi harus berusaha mencari untuk meningkatkan kebugaran jasmani pada masa pandemi covid-19.
Outpatient treatment of cerebral aneurysms: A case series
Authors: Goland Javier , Doroszuk Gustavo , Ypa Paula , Leyes Paula , Garbugino Silvia 
Published: November 2020

Background:
Major advances in the endovascular treatment of cerebral aneurysms have reduced the incidence of intra- and postprocedural complications. The length of stay after treatment for incidental aneurysms remains between early next-day discharge and 2 days. We hypothesized that discharging patients the same day would not be associated with any increase in the rate of postdischarge adverse events.

Methods:
We retrospectively reviewed the charts of patients who underwent an elective coiling procedure between 2015 and 2020 at three centers and were discharged from hospital on the same day as the procedure. Patients were clinically evaluated 6 h, 1 week, and 6 months after the procedure, with repeat cerebral angiography performed 1 year after the procedure.

Results:
Eleven eligible patients underwent outpatient treatment of 12 aneurysms treated through the wrist. No complications were identified within 1 week of the procedure. Clinical evaluation 6 months after treatment also failed to reveal any complication associated with the procedure. Only one of the seven patients who underwent 1 year angiography required retreatment.

Conclusion:
It is possible to safely perform coiled embolization of cerebral aneurysms in select outpatients with unruptured cerebral aneurysms.
Endoscopic interlaminar lumbar discectomy: How to decrease the learning curve
Authors: Elkheshin Sherif Elsayed , Soliman Ahmed Y. 
Published: November 2020

Background:
Herniated lumbar disc is a common cause of lumbosacral pain. Endoscopic interlaminar lumbar discectomy (ILD) is a well-established technique that provided comparable results to micro-discectomy. The aim of the study is to describe the learning curve of endoscopic ILD and explore measures that could improve effectiveness and decrease blood loss and operative time with accumulation of reasonable experience.

Methods:
This retrospective cohort study included 65 patients presenting with symptomatic herniated lumbar disc who underwent endoscopic ILD. Patients were divided into two groups: Group I (standard technique) and Group II (modified technique). Collected data included patients’ age, gender, preoperative manifestations, visual analog score (VAS) for pain, Oswestry Disability Index (ODI), disc level, operative time, intraoperative blood loss, complications, and follow-up data at 1, 6, and 12 months postoperatively. Primary outcomes included total operative time, amount of intraoperative blood loss, and post-operative improvement in pain. Secondary outcomes included intraoperative complications, rate of conversion to open surgery, and recurrence.

Results:
Post-operative VAS and ODI improved significantly in both groups. Mean total surgical time and intraoperative blood loss were significantly lower in Group II compared to Group I (P < 0.001). The learning curves for operative time and intraoperative blood loss were shallow in Group I, and almost flattened in Group II. Complications were recorded in only three cases, and no symptomatic recurrences were reported.

Conclusion:
The learning curve of endoscopic ILD was shallow with standard technique, indicating difficulties in mastering the procedure. The proposed modified technique helped reaching the required level of proficiency in the early phase of the curve, providing a significant reduction in operative time and blood loss, with comparable effectiveness and safety as the standard technique.
Microstructural changes in the perihematomal area in case of the unfavourable course of spontaneous intracerebral hematomas
Authors: Netliukh A.M. , Shevaha V.M. , Falion R.I. , Matolinets N.V. , Mandziuk B.O. , Kobyletskyi O.Yа. 
Published: November 2020

Objective ‒ to determine the dependence of unfavourable treatment outcomes of spontaneous intracerebral hematomas (ICH) on the peculiarities of microstructural changes in the perihematomal area.Materials and methods. A prospective study was conducted that included 68 patients with haemorrhagic stroke and chronic arterial hypertension, as well as signs of ICH. Patients’ clinical condition and treatment outcomes were assessed. The brain data of five patients who died at different stages after the haemorrhagic stroke were analysed using the method of optical microscopy of autopsy material. Results. Patients’ age ranged from 38 to 59. At the time of hospitalization, the Glasgow Coma Scale score was 8 to 15. The inpatient period was less than 1 day for three patients with stem and medial ICH, and 10 and 34 days in case of subarachnoid haemorrhage (in the latter cater, there was an aneurism re-rapture 3 days before death). Blood in the ventricular system was observed in all patients. Gross examination data during the autopsy showed that the cortical layer above the affected area is thin; after 12‒24 hours, the perihematomal area is swollen, with small dotted, and sometimes coalesced haemorrhaging; after 3 and more days, it increased to 4–5 mm and turned reddish-brown. During histologic examination: brain tissue with signs of the swelling, perihematomal area is cell-like with nerve cells – ranging from minor changes to extreme dystrophia and coagulative necrosis (nuclei with signs of pyknosis, rhexis, lysis), homogenous eosinophilic cytoplasm, apparent pericellular swelling, cell shaft formed by lymphocytes, leukocytes, macrophages, hemosiderophages, and reactive increase in oligodendrocytes and astrocytes.Conclusions. Perihematomal area has been found to be not just a «perihematomal swelling» as described in the literature. The unfavourable course of the ICH of different localization (basal, stem) can be explained by a complex of pathomorphological changes in this area: reactive inflammatory activation of glia, dystrophic nerve cell changes, pericellular swelling. As seen from our observations, early development of these processes – as early as on the 1st day – and their progressing indicate the presence of common mechanisms of unfavourable outcome regardless of haemorrhagic stroke localisation.
Examining the Outcomes of Sport Specialization for Individual Athletes and the Industry
Authors: Alongi Carolina , Clark Martyn , Hamilton Leah K. 
Published: November 2020

Sport specialization for young athletes has become a prerequisite for sport achievement, but academics have yet to explore the effects that sport specialization has on athletes’ participation patterns. Thus, this project explores the following research question: what are the effects of sport specialization on the individual volleyball athlete in terms of: i) patterns of participation in sport; and ii) consumption patterns in the sport industry? The methodological approach was to interview current and retired volleyball players aged 18 to 30 in Calgary, Alberta. The findings indicate that specialization in volleyball directly impacts an athlete’s patterns of participation in the sport of volleyball and the sport industry broadly. Participants indicated that their specialization years led to a specialized “mindset” and specialized knowledge, a unique analytical experience that influences sport participation and few individuals outside of the specialized athletic community acquire. Many participants also articulated that specialized training led to an identity as a “volleyball player” which was associated with a reduced desire to participate in other sports recreationally. Many participants explained how specialization affected their socialization (both positively and negatively) and led them to foster connections in a virtual community. The findings are a call to action for the volleyball industry to evaluate the participation patterns in specialized volleyball training and implement changes to benefit specialized athletes and the industry.
Keywords: sport specialization, participation, sport industry, volleyball