bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selected hematological biomarkers to predict acute mortality in emergency department patients: Recent Polish hospital statistics
Authors: Brzeźniakiewicz-Janus Katarzyna , Lancé Marcus Daniel , Tukiendorf Andrzej , Janus Tomasz , Franków Mirosław , Rupa-Matysek Joanna , Walkowiak Zuzanna , Gil Lidia 
Published: April 2020

Abstract
Background
Complete blood count (CBC): red cell distribution width (RDW), mean platelet volume (MPV), mean corpuscular volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), or platelet (PLT) count are referred as predictors of adverse clinical outcomes in patients. The aim of the research was to identify potential factors of acute mortality in Polish ED patients by using selected hematological biomarkers and routine statistical tools.
Methods
The study presents statistical results on patients who were recently discharged from inpatient facilities within one month prior to the index emergency department (ED) visit. In total, the analysis comprised 14,904 patients with the first RDW, MPV, MCV, MCH, MCHC, or PLT biomarkers’ measurements recorded in the Emergency Department within the years 2016–2019 with a subsequent one month of all-cause mortality observation. The patients were classified with the codes of the International Statistical Classification of Diseases and Related Health Problems after 10th Revision (ICD10).
Results
Based on the analysis of RDW, MPV, MCV, MCH, MCHC, and PLT on acute deaths in patients, we establish strong linear and quadratic relationships between the risk factors under study and the clinical response (P < 0.05), however, with different mortality courses and threats. In our statistical analysis, (1) gradient linear relationships were found for RDW and MPV along an entire range of the analyzed biomarkers’ measurements, (2) following the quadratic modeling, an increasing risk of death above 95 fL was determined for MCV, and (3) no relation to excess death in ED patients was calculated for MCH, MCHC and PLT.
Conclusion
The study shows that there are likely relationships between blood counts and expected patient mortality at some time interval from measurements. Up to 1 month of observation since the first measurement of an hematological biomarker, RDW and MPV stand for a strong relationship with acute mortality of patients, whereas MCV, MCH, MCHC, and PLT give the U-shaped association, RDW and MPV can be established as the stronger predictors of early deaths of patients, MCV only in the highest levels (> 95 fL), whereas MCH, MCHC, and PLT have no impact on the excess acute mortality in ED patients.
Parvabumin interneuron-mediated hippocampal network activity disruption in a two-hit model with relevance to postintensive care syndrome: prevention by fluoxetine
Authors: Ji Mu-huo , Tong JianHua , Zhou Zhi-qiang , Yang Jian-Jun 
Published: April 2020

Abstract
Background

Postintensive care syndrome (PICS) is defined as a new or worsening impairment in cognition, mental health, and physical function after critical illness, which is associated with reduced quality of life and increased mortality. We recently have developed a clinically relevant animal model of PICS, which can mimic most features of human PICS. However, the underlying mechanism remains largely to be elucidated. Accumulating evidence has suggested that hippocampal GABAergic interneuron dysfunction is implicated in various mood disorders induced by stress.
Methods

We explored the role of hippocampal GABAergic interneurons and relevant neural activities in an animal model of PICS based on two-hit hypothesis. In addition, we tested whether fluoxetine treatment early following combined stress can prevent subsequent anatomical and behavioral pathologies.
Results

Here our study further supported our previous findings that this PICS model displayed reproducible anxiety- and depression like behavior and cognitive impairments, which resembles clinical features of human PICS. This behavioral state is accompanied by hippocampal neuroinflammation, reduced parvalbumin (PV) expression, and decreased theta and gamma power. Importantly, chronic fluoxetine treatment reversed most of these abnormities.
Conclusions

Our study provides additional evidence that PV interneuron-mediated hippocampal network activity disruption might play a key role in the pathological of PICS, while fluoxetine offers protection via modulation of the hippocampal PV interneuron and relevant network activities.
Relationship between neuropsychology, clinical traits, psychopathology and attitudes towards change in eating disorders
Authors: Mata-Saenz Beatriz , Rodríguez-Cano Teresa , Muñoz-Martínez Victoria Eugenia , Beato-Fernández Luis 
Published: April 2020

Abstract
Background:Recent models try to find in eating disorders (ED) a relationship between the neuropsychological dimensions, the psychopathological disturbances and the clinical manifestations. Carrying out an investigation on neuropsychological aspects that may be related with an ED’s characteristic cognitive pattern could contribute to their possible influence towards therapeutic change. The main objective of this paper is to analyse the possible relationship between psychopathological and clinical variables with the neuropsychological characteristics of patients diagnosed with an ED and their possible influence on the attitude towards change. Methods:An observational analytical transversal study was done. Patients were outpatients referred during a 6-month period who signed informed consent. Seventy-four subjects were included. Clinical (Psychiatric Status Rating Scale modified) and neuropsychological tests (Letter Number Sequencing; Stroop’s test; Symbol and Digit Modalities Test; Rey-Osterrieth complex figure test) were administrated and psychopathological self-report questionnaires (Body Shape Questionnaire; Eating Disorders Inventory; The Bulimic Investigatory Test, Edinburgh; Beck’s depression inventory; State-Trait Anxiety Inventory; Dissociative Experiences Scale; Attitudes Towards Change in Eating Disorders Scale) were given (but 23 participants, 31.08%, did not give them back).Results:Nineteen patients (25,68%) were diagnosed with restrictive anorexia nervosa (AN), 19 (25,68%) purgative AN, 14 bulimia nervosa (18,92%), 9 binge eating disorder (12,16%) and 13 ED not otherwise specified (17,57%). There are not any significant differences between the diagnoses with regards to the score of neuropsychological tests. BMI was related to the majority of the neuropsychological scores. “Precontemplation” was related to time of copy (B=3.56; IC 95% (0.82-6.29), p<0,01) and time of memory (B=-2.31; IC 95% (-4.58-(-0.05)); p<0.05). “Contemplation” was related to time of copy (B=1.43; IC 95% (0.42-2.45); p<0.01) and index of style (B= -14.01; IC 95% (-24.98-(-3.04)); p<0.01). “Decision” was related to working memory (SpanLN), quantitative score of copy, index of order and index of style.Conclusions:Neuropsychological alterations could be summarized as the working memory is lowered and the interference is increased, which is associated with a more controlling and less flexible attitude, and scores in inhibitory care are lower. ROCFT shows a visoperceptive deficit in some patients.
Depression, Anxiety, Stress, and Satisfaction with Life: Moderating Role of Interpersonal Needs among Undergraduate Students
Authors: Tan Choe Chai , Khor Kuan Siew , Ooi Pei Boon 
Published: April 2020

Abstract
BackgroundDepression, anxiety, and stress are ranked among the top mental health concerns faced by undergraduate students. The transition to higher education coincides with the new social environment and adaptation that has potential to increase mental illness.AimsIn this cross-sectional study, the Depression, Anxiety and Stress Scale, Satisfaction with Life Scale and Interpersonal Needs Questionnaire were used to examine depression, anxiety, stress, interpersonal needs, and satisfaction with life among 430 undergraduate students in two private universities in Malaysia.MethodThis study conducted hierarchical regression analysis to show that thwarted belongingness accentuates the negative relationship between stress and satisfaction with life.ResultsThe study also showed that students, who reported higher perceived burdensomeness, appeared to be less than satisfied in life, but there is a positive relationship between (i) depression and (ii) anxiety with satisfaction with life.ConclusionsFindings and suggestions for mental health practitioners, researchers and teaching staff, are put forward.
Safety review of 42 cases of COVID-19 treated with low-dose chloroquine
Authors: Zhou Bo , Zhang Jing , Liu Yanqing , Hong Wenxin , Jian Fengbi , Wang Ming , Tan Jun , Cai Weiping , Zhang Fuchun , Li Linghua 
Published: April 2020

Abstract
BackgroundCoronavirus Disease 2019 (COVID-19) has become a global pandemic and caused over one hundred thousand death. Chloroquine (CQ) and hydroxychloroquine (HCQ) were recommended for off-label use in the treatment of COVID-19 in some countries despite their unclear benefit. However, the toxicity of these agents has been ignored, so the investigation of their safety in the treatment of COVID-19 is crucial for providing a reference for the rational use. MethodsThe medical records obtained from the information management system of Guangzhou Eighth People’s Hospital were reviewed to extract data about patients who received chloroquine phosphate tablets for COVID-19 treatment from January 20th to March 5th, 2020. The data were assessed to determine the correlation of adverse reaction with chloroquine phosphate based on Chinese CFDA standards as well as the severity of adverse events based on American CTCAE5.0 standard, and evaluate the safety of this medication.ResultsA total of 42 patients (23 males and 19 females, average 42.19±14.29 years old) with COVID-19 were treated with low-dose chloroquine phosphate (oral, 500 mg, once per day). Totally 18 patients（42.86%）experienced 20 adverse events. The mean duration of CQ administration was 6.57 days (SD, 3.16 days; range: 1 day to 16 days) and 52.4% received CQ for 7 to 9 days. The adverse events occurred within 6–8 days of treatment. For the 20 adverse events, 19 were not higher than grade 2 and only one was grade 3 because of the severely limited self-care ability in one patient. The most common adverse events were related to the digestive, circulatory, hepatic, and nervous systems.ConclusionOral chloroquine phosphate tablets resulted in a high incidence of adverse reactions. In the clinical trial of chloroquine phosphate for COVID-19 treatment, it should be used under pharmaceutical care; timely evaluation of the drug safety during the treatment process is necessary and a randomized controlled clinical trial should be conducted.
Oral symptoms and oral health related quality of life in people with Ehlers-Danlos syndromes (EDS): a questionnaire-based cross-sectional study
Authors: Hanisch Marcel , Blanck-Lubarsch Moritz , Maus Melanie , Suwelack Dominik , Bohner Lauren , Kleinheinz Johannes , Köppe Jeanette 
Published: April 2020

Abstract
Background: To date, there have only been a few studies on the oral health-related quality of life (OHRQoL) of people with Ehlers-Danlos syndromes (EDS) and the oral symptoms. The aim of this study was, therefore, to analyse the OHRQoL of people with EDS from their own point of view as well as obtain information about their age at the time of the diagnosis, the period of time until diagnosis, and the presence of oral symptoms (if any) and their association with oral health quality.Methods:The study was designed as an anonymous questionnaire-based cross-sectional study. We conducted a descriptive analysis of the Oral Health Impact Profile-14 (OHIP-14) scores, age of the participants, age at diagnosis, and the time period between the first signs of the disease and the diagnosis of EDS. To verify the differences in OHIP-14 scores between patients with and without oral symptoms, a Mann-Whitney U test was performed.A multivariate quantile (median) regression analysis was performed to evaluate the effect of different general characteristics (gender, age, and the presence of oral symptoms) on the OHIP‑14 scores. Furthermore, using a Mann-Whitney U test, the influence of different oral symptoms was verified by testing the differences between patients without any oral symptoms and patients with a specific diagnosis.Results:A total of 79 evaluable questionnaires from 66 female (83.5%) and 13 male (16.5%) participants were analysed. On average, after the first symptom, it takes 18.36 years before EDS are correctly diagnosed.Oral symptoms were described by 69.6% of the participants. The OHIP-14 score was 8 (10) points for patients without oral symptoms and 19 (15) for patients with oral symptoms. The quantile regression for OHIP-14 scores, depending on oral symptoms, was highly significant (p = 0.0007). OHIP-14 scores for dysgnathia, periodontitis, TMD, a high-arched palate, malocclusion, and the anomaly of tooth formation were significantly different between the participants with and the participants without oral symptoms.Conclusion:Long diagnostic pathways seem to be a typical problem in patients with EDS. Oral symptoms associated with the underlying disease occurred regularly and showed a negative correlation with OHRQoL.
Predictors of Short-Term Mortality after Heart Valve Surgery: A Single-Center Study; Retrospective analysis
Authors: ibrahim Khalid , Kheirallah Khalid , Mayyas Fadia , Alwaqfi Nizar , Alawami Murtaha , AlJarrah Qusai 
Published: April 2020

Abstract
Objective

To investigate predictors of short-term mortality after valve surgery at our center.
Methods

The study cohort included 346 patients who underwent different types of valve surgery, excluding redo and Bentall operations. All operations were performed through a median sternotomy using cardiopulmonary bypass.
Results

Mean patient age was 51.6 ± 16.1 years, and 51% were male. Approximately 21% had diabetes, and 44.6% were hypertensive. Aortic valve replacement (AVR) was performed in 125 patients (37%), mitral valve replacement (MVR) in 95 (28%), combined AVR and MVR in 42 (13%), AVR plus coronary artery bypass grafting (CABG) in 19 (6%), and MVR plus CABG in 32 (10%). Operative mortality was 5.8% (n = 20). In the bivariate-level analysis, older age, operation type, hypertension, emergency surgery, use of a biological valve in the aortic or mitral position, pump time greater than 120 minutes, and aortic clamp time greater than 60 minutes were significant predictors of 30-day mortality. Use of angiotensin-converting enzyme inhibitors, digoxin, beta-blockers, statins, and loop diuretics was associated with mortality. Older age, emergency/salvage surgery, use of beta-blockers for less than 1 month preoperatively, and use of a biological valve in the aortic position were significant and independent predictors of 30-day mortality.
Conclusion

Older age, emergency valve surgery, use of a biological valve, and use of beta-blockers for less than 1 month before surgery were all found to be independent predictors of mortality in patients undergoing valve surgery.
Radial versus femoral access percutaneous coronary intervention in patients with acute myocardial infarction: Experience from a Southeast Asian country PCI registry
Authors: Ismail Muhammad Dzafir , Firdaus Mohd Al-Baqlish Mohd , Hadi Mohd Firdaus , Azhari Zaid , Hafidz Muhammad Imran Abdul , Zuhdi Ahmad Syadi Mahmood , Ahmad Wan Azman Wan 
Published: April 2020

Abstract
IntroductionBleeding complications adversely affect patient’s outcomes following percutaneous coronary intervention (PCI). Radial approach PCI was advocated to overcome this complication. The information regarding the safety and feasibility of radial approach PCI in acute myocardial infarction (AMI) in the Southeast Asian population was limited. Hence, we sought to examine the outcome of radial versus femoral approach in this particular cohort.Materials and MethodsThis is an observational retrospective analysis of the Malaysian National Cardiovascular Disease Database-Percutaneous Coronary Intervention (NCVD – PCI) registry, recruiting patients with AMI from 2007 – 2014. Patients were stratified into radial and femoral groups depending on the PCI access route. The patient's baseline characteristics, lesion, and procedural data, complications, and outcomes are assessed accordingly.ResultsA total of 11,555 (4895 radial and 6660 femoral) cases were included in the analysis. In the radial group, there were predominantly more males (89.2%) with the younger patient (mean age 55.2 ± 10.5 years) as compared to the femoral group. They also had a higher body mass index (BMI) and taller. However, femoral group patients had significantly more premorbid conditions, namely diabetes mellitus, hypertension, previous stroke, heart failure, and chronic kidney disease. Complex lesions were similar in both groups with no difference in fluoroscopy time, although higher contrast load recorded in the femoral group. The adjusted odds ratio of developing in-hospital complications after femoral approach PCI compared to radial approach for death, MACE and vascular complications were OR: 8.21 95% CI 5.38 – 12.54, OR: 3.39 95% CI 2.51 – 4.58, OR: 1.79 95% CI 1.01 – 3.16 respectively. ConclusionPCI via the trans-radial approach has resulted in a significantly lower risk of vascular complications, MACE and death compared to the trans-femoral approach. Our study confirmed the superiority of the trans-radial approach in the setting of primary PCI in the Southeast Asian population and underscores the importance of trans-radial interventions to reduce bleeding complication rates.
Long non-coding RNA FAM83H-AS1 induced by adipose-derived stem cells promotes breast and pancreatic cancer cell proliferation and migration
Authors: Tang Jianing , Cui Qiuxia , Zhang Dan , Liao Xing , Gong Yan , Wu Gaosong 
Published: April 2020

Abstract
Background

Stromal cells recruited to the tumor microenvironment and long non-coding RNAs (lncRNAs) in the tumor cells regulate cancer progression. However, their relationship is largely unknown.
Methods

In the current study, we identified the effects of lncRNA FAM83H-AS1, induced by adipose-derived stem cells (ADSCs) during tumor development, and explored the underlying mechanisms using a coculture cell model. Adipose tissues were obtained from healthy female donors, the expression of stromal markers on cell surface of expanded ADSCs were confirmed using immunofluorescence analysis. The breast and pancreatic cancer cells were cultured with or without ADSCs using 24-well transwell chamber systems with 8.0 µm pore size.
Results

Our results showed that FAM83H-AS1 was upregulated in breast and pancreatic cancers and associated with poor prognosis. ADSCs further induced FAM83H-AS1 and increased tumor cell proliferation via promoting G1/S transition through cyclin D1, CDK4 and CDK6. Wound healing, modified Boyden chamber and immunoblotting assays demonstrated that ADSCs induced epithelial-mesenchymal transition and migration of breast and pancreatic cancer cells in a FAM83H-AS1-dependent manner. And ADSC-induced FAM83H-AS1 increased unfolded protein response through AKT/XBP1 pathway.
Conclusion

In conclusion, our results indicated that ADSCs promoted breast and pancreatic cancer development via inducing cell proliferation and migration, as well as unfolded protein response through FAM83H-AS1.
Antimicrobial Resistance Profile among clinical isolated bacteria at Wolaita Sodo University Teaching Referral Hospital, three year retrospective cohort study
Authors: Anjulo Temesgen Ageru , Seid Habtamu , Sidamo Temesgen , Balcha Tamrat , Lera Temesgen 
Published: April 2020

Abstract
Background

Antibiotic resistance is public threats in globally and its problem not well concerned in sub Saharan Africa including Ethiopia due to inadequate set up. However, there is information gap in resistance of antibiotic and its pattern for physicians who prescribe. Therefore, the aim of this study was to review the antimicrobial resistance pattern of bacterial isolated from different specimens inoculated retrospectively at Wolaita Sodo University Teaching Referral Hospital, Southern Ethiopia.
Methods

A 3 year retrospective data of culture and antibiotic sensitivity pattern analyzed from 2016–2018 among 330 patients records at Wolaita Sodo university Teaching Referral hospital. The data extracted were clinical samples taken, age, sex, bacteria growth status, bacteria isolated, antibiotic resistance profile and trend in each year.The data entry was done using Epidata version 3.5.1 and exported to SPSS version 21 software for cleaning and statistical analysis.Bivariable analysis was done and variables with p-value of less than 0.25 were made candidate for multiple logistic regression analysis. The relative contribution of each selected variables to the outcome of interest was assessed using multiple logistic regression and variables with P-value less than 0.05 were considered as statically significant.
Results

A total of 330 samples fulfills inclusion criteria were extracted from microbiology laboratory, 150 samples were become culture positive for bacteria isolates. From positive culture growth, 110 (73.3%) was gram positive bacteria and 40(26.7%) gram negative. A staphylococcus auras (S.auras) was the most prevalent isolate 97 (61.3%) from gram positive isolates and Escherichia coli (E. coli) 19(12.7%) was gram negative. From gram positive isolates S. auras was 53% and S. saprophytes 62%, S. pyogen 74% and S.pneumonia 52% resistance to antibiotics. Overall resistance for all antimicrobial resistance of gram negative of E. coli was 62%, P. aurogenous 75%, proteusspp 65%, shigellaspp 66%, salmonella 56% and NisseriaSpp 63%.Overall antimicrobial resistance of gram positive isolates was 54.2% gram negative bacteria was 60.0%
Numerical simulation analysis of anchorage characteristics of constant-resistance and large-deformation anchor cable for highly weathered rock masses
Authors: Zhigang Tao , Fei Deng , Zhicai WANG , Xiaobing QIAO , Mengnan LI , Shengxin Xu 
Published: April 2020

Abstract
In order to effectively maintain the stability of high and steep loose slopes around the site of the Tonglushan Ancient Copper Mine in Daye City, Hubei Province, the NPR anchor cable reinforcement system was introduced. Based on the significance of anchorage characteristics of NPR anchor cable for the whole reinforcement system, we first investigated and analyzed the engineering geological conditions of the ancient smelting site slopes, while selected a typical highly weathered section to establish a numerical simulation calculation model. Following, utilized the FLAC3D method to numerically calculate the reinforcement effect of NPR anchor cables under various anchorage lengths. Finally, based on the calculation results, we reveal the changes in displacement, as well as in stress and anchor cable axial force of the site slope, analyzing the shear strain rate and evolution characteristics of plastic zone near the potential sliding surface. The calculation results show that as the NPR anchorage length increase, the displacement gradually decrease. Moreover, the maximum axial force of the NPR anchor cable and the principal stress of the slope change slightly, while the plastic failure range gradually decrease; when the anchorage length is 20m, the safety factor reach the peak value and the reinforcement effect is optimal, which lay the theoretical and practical foundation for the reinforcement control of similar site slopes.