bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers to patient, provider, and caregiver adoption and use of electronic personal health records in chronic care: a systematic review
Authors: Niazkhani Zahra , Toni Esmaeel , Cheshmekaboodi Mojgan , Georgiou Andrew , Pirnejad Habibollah 
Published: June 2020

Abstract
Background Electronic personal health records (ePHRs) are defined as electronic applications through which individuals can access, manage, and share health information in a private, secure, and confidential environment. Existing evidence shows their benefits in improving outcomes, especially for chronic disease patients. However, their use has not been as widespread as expected partly due to barriers faced in their adoption and use. We aimed to identify the types of barriers to a patient, provider, and caregiver adoption/use of ePHRs and to analyze their extent in chronic disease care.Methods A systematic search in Medline, PubMed, Science Direct, Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Central Register of Controlled Trials, and the Institute of Electrical and Electronics Engineers (IEEE) database was performed to find original studies assessing barriers to ePHR adoption/use in chronic care until the end of 2018. Two researchers independently screened and extracted data. We used the PHR adoption model and the Unified Theory of Acceptance and Use of Technology to analyze the results. The Mixed Methods Appraisal Tool (MMAT) version 2018 was used to assess the quality of evidence in the included studies.Results Sixty publications met our inclusion criteria. Issues found hindering ePHR adoption/use in chronic disease care were associated with demographic factors (e.g., patient age and gender) along with key variables related to health status, computer literacy, preferences for direct communication, and patient’s strategy for coping with a chronic condition; as well as factors related to medical practice/environment (e.g., providers’ lack of interest or resistance to adopting ePHRs due to workload, lack of reimbursement, and lack of user training); technological (e.g., concerns over privacy and security, interoperability with electronic health record systems, and lack of customized features for chronic conditions); and chronic disease characteristics (e.g., multiplicities of co-morbid conditions, settings, and providers involved in chronic care).Conclusions ePHRs can be meaningfully used in chronic disease care if they are implemented as a component of comprehensive care models specifically developed for this care. Our results provide insight into hurdles and barriers mitigating ePHR adoption/use in chronic disease care. A deeper understating of the interplay between these barriers will provide opportunities that can lead to an enhanced ePHR adoption/use.
Tobacco exposure as a major modifier of oncologic outcomes in Human PapillomaVirus (HPV) associated oropharyngeal squamous cell carcinoma
Authors: Elhalawani Hesham , Mo Abdallah S.R. , Elgohari Baher , Lin Timothy A. , Sikora Andrew G. , Lai Stephen Y. , Abusaif Abdelrahman , Phan Jack , Morrison William H. , Gunn G. Brandon , Rosenthal David I. , Garden Adam S. , Fuller Clifton D. , Sandulache Vlad C. 
Published: June 2020

Abstract
Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the US is rapidly increasing, driven largely by the epidemic of human papillomavirus (HPV)-mediated OPSCC. Although survival for patients with HPV mediated OPSCC (HPV+ OPSCC) is generally better than that of patients with non-viral HPV+ OPSCC, the improvement is not uniform. We hypothesized that tobacco exposure remains a critical modifier of survival for HPV+ OPSCC patients. Methods: We conducted a retrospective analysis of 611 OPSCC patients with concordant p16 and HPV testing treated at a single institute (2002-2013). Survival analysis was performed using Kaplan-Meier analysis and Cox regression. Recursive partitioning analysis (RPA) was used to define tobacco exposure associated with survival (p<0.05). Results: Tobacco exposure impacted overall survival (OS) for HPV+ patients on univariate and multivariate analysis (p=0.002, p=0.003 respectively). RPA identified 30 pack-years (PY) as a threshold at which survival became significantly worse in HPV+ patients. OS and disease-free survival (DFS) for HPV+ >30 PY patients didn’t differ significantly from HPV- group (p= 0.72, p= 0.27, respectively). HPV+ >30 PY patients had substantially lower 5-year OS when compared to their ≤30 PYs counterparts: 78.4% vs 91.6%; p= 0.03, 76% vs 88.3%; p= 0.07, and 52.3% vs 74%; p= 0.05, for stages I, II, and III (AJCC 8 th Edition Manual), respectively. Conclusions: Tobacco exposure can eliminate the survival benefit associated with HPV+ status in OPSCC patients. Until this effect can be clearly quantified using prospective datasets, de-escalation of treatment for HPV+OPSCC smokers should be avoided.
A single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni
Authors: Eissa Maha Mohamed , El-Azzouni Mervat , El-Khordagui Labiba Khalil , Bary Amany Abdel , El-Moslemany Riham Mohamed , Salam Sara Ahmed Abdel 
Published: June 2020

Abstract
Background: The control of schistosomiasis has been centered to date on a single drug, praziquantel (PZQ), with shortcomings including treatment failure, reinfection, and emergence of drug resistance. Drug repurposing, combination therapy or nanotechnology were explored to improve antischistosomal treatment. The aim of the present study was to utilize a novel combination of the three strategies to improve the therapeutic profile of PZQ. This was based on a fixed dose nanocombination of PZQ and miltefosine (MFS), an antischistosomal repurposing candidate, co-loaded at reduced doses into lipid nanocapsules (LNCs), for single dose oral therapy. Methods: Two nanocombinations were prepared to provide 250 mg PZQ-20 mg MFS/kg (higher fixed dose) or 125 mg PZQ-10 mg MFS/kg (lower fixed dose) respectively. Their antischistosomal efficacy in comparison with nontreated control and their PZQ or MFS singly loaded counterparts was assessed in murine schistosomiasis mansoni. A single oral dose of either formulation was administered on the initial day of infection, the 21 st and 42 nd days post infection. Scanning electron microscopic (SEM), parasitological and histopathological studies were used for assessment. Preclinical data were subjected to analysis of variance and Tukey post hoc test for pairwise comparisons. Results: Compared to singly loaded PZQ-LNCs, the higher dose nanocombination showed a significant increase in antischistosomal efficacy in terms of % reduction in worm burden, particularly against invasive and juvenile worms, and amelioration of hepatic granulomas. The efficacy of the higher dose nanocombination was significantly greater than that of its lower dose counterpart. SEM showed extensive dorsal tegumental damage with noticeable deposition of nanostructures. Conclusions: The therapeutic profile of PZQ could be improved by a novel multiple approach integrating drug repurposing, combination therapy and nanotechnology. Multistage activity and amelioration of liver pathology could be achieved by a new PZQ-MFS fixed dose nanocombination providing 250 mg PZQ-20 mg MFS/kg. To the best of our knowledge, this is the first report of a fixed dose nano-based combinatorial therapy for schistosomiasis mansoni. Further studies are needed to document the nanocombination safety and explore its prophylactic activity and potential to hinder the onset of resistance to the drug components. Key words: Praziquantel, miltefosine, lipid nanocapsules, Schistosoma mansoni, nanocombination, multistage activity, tegumental targeting, scanning electron microscopy
A novel research method for workshops and co-production of interventions: using a secret Facebook group
Authors: Buelo Audrey , Kirk Alison , Jepson Ruth 
Published: June 2020

Abstract
Background: Co-production of interventions is reliant on good communication and consensus between participants and researchers but attending in-person meetings and workshops is hard for time-constrained groups such as new mums, who may be geographically dispersed without reliable transport. Discussions with a lay advisory group resulted in the decision to hold a workshop over a secret Facebook group. The aim of this study was to test the feasibility a secret Facebook group for co-production activities. In the example presented, the population was women with previous gestational diabetes; the topic was physical inactivity; and the purpose was to develop an acceptable physical activity intervention.Methods: The researchers created a secret Facebook group with content similar to an in-person workshop that sequentially progressed to develop a programme theory for an intervention. The researcher posted 1-2 times per day for 14 days and members of the group were invited to comment and discuss the content. Feasibility and acceptability of the group analysed using Facebook analytics and a post-workshop survey.Results: Twenty-one participants took part. In total, 521 comments were provided in response to 18 posts of varying types (average = 28.9 comments per post). The total word count of participant comments was 21,142 words. The workshop was viewed positively, with 20 of 21 participants saying they liked the workshop ‘somewhat’ or ‘a great deal’, and felt the group was a safe and open environment to share opinions. When asked if they would take part in something like this again, 15 of 21 said “Yes”. Participants mentioned the format was convenient; it allowed them to reflect on their experiences and they liked helping research progress. Those who say “maybe” said it was difficult finding time and depended on what else was going on.Conclusion: Using a secret Facebook group as a method of co-production or as a workshop in the research process is a feasible and acceptable method. Social media holds significant potential for co-production and involvement in research for populations who are geographically dispersed or time-constrained; with an uncommon condition; or other circumstances where in-person meetings are either not appropriate or not possible.
A comprehensive study on the oncogenic mutation and molecular pathology in Chinese lung adenocarcinoma patients
Authors: Zhang Xilin , Jiang Yan , Yu Huanming , Xia Hui , Wang Xiang 
Published: June 2020

Abstract
Background: Several driver genetic alterations have been identified in micropapillary lung adenocarcinoma (MPA). However, the frequency of ROS1 rearrangements is yet unclear. Herein, we investigated the associations between clinicopathological and molecular characteristics of MPA compared with non-micropapillary lung adenocarcinoma (LA). Methods: Formalin fixed paraffin-embedded (FFPE) sections derived from lung adenocarcinoma patients who never received adjuvant chemotherapy or radiation therapy prior to surgical resection were collected from October 2016 to June 2019. EGFR mutations, ROS1 rearrangement and EML4-ALK fusion were identified in a set of 131 MPA and LA cases by using the Amplification Refractory Mutation System (ARMS). Results: EGFR mutations had occurred in 42 (76.4%) MPA patients and 42 (55.3%) LA patients. But interestingly, ROS1 rearrangement was present in 10.9% (6/55) MPA cases and 1.3% (1/76) LA cases. Moreover, 7.3% (4/55) MPA samples had multiple gene mutations, while only 1.3% (1/76) LA cases had double gene alterations. Of 5 patients with harbouring two driver oncogenes mutations, four patients (80%) obtained partially response and one patient (20%) suffered recurrence. Conclusions: A higher prevalence of ROS1 rearrangements or combined mutations of ROS1 and EGFR or EML4-ALK may play a critical role in the tumorigenesis of MPA. These findings provide a novel therapeutic strategy for the patients with malignant MPA through combining TKIs than one TKI.
Understanding mobile application development and implementation to monitor Posyandu data in Indonesia: a 3-years hybrid action research to build “a bridge” from the community to national use
Authors: Rinawan Fedri Ruluwedrata , Susanti Ari Indra , Amelia Indah , Ardisasmita Mulya Nurmansyah , - Widarti , Dewi Rima Kusumah , Ferdian Dani , Purnama Wanda Gusdya , Purbasari Ayi 
Published: June 2020

Abstract
Background. There is a small number of facts available to understand better how mobile health application technology on mother and child health (MCH) is developed. This study is aimed: (a) to explore the process of developing the mobile app in MCH community-based services in the Indonesian setting/Posyandu, (b) to perform feasibility assessment among the community health workers (CHWs), and (c) to see the potential use of the mobile app in the country. Method. Using a hybrid method in which the action research principles and the mixed-method, which comprise qualitative and quantitative methods, were synergistically combined for the end-users. The study was conducted in Pasawahan sub-district, Purwakarta, Indonesia, from 2017 to 2019. Content analysis, coding, and categorizing were carried out using NVivo 12 Pro for the transcribed data. Wilcoxon Test (2018 and 2019) was conducted using STATA 15 Special Edition. Results. (1) The use of a CHW notebook for data entry in the Posyandu information system book delayed the data reporting process, resulting in the need to develop a mobile app; (2) There are significant differences of CHW’s knowledge (p=0.000) and skills (p=0.0097) on training (2018) and Posyandu phases (2019); (3) As many as 964 posyandu are registered to Posyandu mobile app from almost all provinces in Indonesia. Conclusions. The 3-years hybrid approach suggests the crucial phases to develop a mobile app in a more user-friendly manner to substitute the use of CHW’s old-fashion book use and that its implementation is promising for national use.
Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer
Authors: Wang Weixia , Lu Kui , Wang Limei , Jing Hongyan , Pan Weiyu , Huang Sinian , Xu Yanchao , Bu Dacheng , Cheng Meihong , Liu Jing , Liu Jican , Shen Weidong , Zhang Yingyi , Yao Junxia , Zhu Ting 
Published: June 2020

Abstract
Aim: The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the effect of schistosomasis on colorectal cancer (CRC) patients` clinical outcomes. Methods: 351 cases of CRC were retrospectively analyzed in this study. Survival curves were constructed by using the Kaplan-Meier (K-M) method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables.Results: Colorectal cancer patients with schistosomiasis (CRC-S) were significantly older (P＜0.001) than the patients without schistosomiasis (CRC-NS). However, there were no significant differences between CRC-S and CRC-NS patients in other clinicopathological features. Schistosomiasis were associated with adverse overall survival (OS) upon K-M analysis (P=0.0277). By univariate and multivariate analysis, gender (P=0.003), TNM stage (P＜0.001), schistosomiasis (P=0.025), lymphovascular invasion (P=0.030) and lymph nodes positive for CRC (P＜0.001) were all independent predictors in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state. Schistosomiasis was also an independent predictors in patients with stage Ⅲ-Ⅳ tumors and in patients with lymph node metastasis, but not in patients with stage Ⅰ-Ⅱ tumors and in patients without lymph node metastasis.Conclusion: Schistosomiasis was significantly correlated with OS and it was an independent prognostic factor for OS in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was still an independent unfavorably prognosis factor for OS in patients with stage Ⅲ-Ⅳ tumors or patients with lymph node metastasis.
Cellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mice offspring
Authors: Su Jianwen , Chai Yu , Ji Zhiguo , Xie Yongheng , Yu Bin , Zhang Xianrong 
Published: June 2020

Abstract
Background: Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE affects postnatal long bone growth in mice offspring. Methods: Pregnant mice were injected subcutaneously with dexamethasone (1.2 mg/kg/day) every morning from gestational day (GD) 12-14. Femurs and tibias of 2-, 4-, 6-, and 12-week-old female offspring were harvested for histological, immunofluorescence, flow cytometric analysis, or microcomputed tomography (μCT) measurement. Results: PDE leads to impaired bone remodeling as well as decreased bone mass in the long bone of female mice offspring. During postnatal bone growth, significant decrease of CD45-CD29+CD105+Sca-1+ bone marrow mesenchymal stem cells (BMSCs) and CD45-Nestin+ cells, loss of type H vessels as well as increment of cellular senescence were found in metaphysis of long bone in mice offspring after PDE. We further show that eliminating the excessive senescent cells with dasatinib (5 mg/kg/day) and quercetin (50 mg/kg/day) during GD 12-14 rescues the above toxic effect of PDE on the postnatal long bone growth in female mice offspring. Conclusion: Cellular senescence mediates the toxic effect of PDE on postnatal long bone growth in mice offspring, and inhibition of cellular senescence may be proposed for treating the retardation of bone growth caused by PDE.
The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis
Authors: Maddahi Niloofarsadat , Yarizadeh Habib , Aghamir SeyedMohammad Kazem , Alizadeh Shahab , Yekaninejad MirSaeed , Mirzaei Khadijeh 
Published: June 2020

Abstract
Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation.Results: Of 264 participants, 61.4% (n= 162), 72% (n=190), 74.6% (n=197), 68.6% (n=181), and 80.3% (n=212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P=≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR=2.80, 95%CI: 1.10-7.12, Ptrend=0.04), hypercalciuria (OR=7.44, 95%CI: 2.62-21.14, Ptrend≤0.001), hyperuricosuria (OR=2.22, 95%CI: 1.001-4.95, Ptrend=0.05), and hypocitraturia (OR=5.84, 95%CI: 2.14-15.91, Ptrend≤0.001). No association was identified between DII and hyperoxaluria.
Next-Generation Sequencing Analysis of Endometrial Screening Liquid-Based Cytology Specimens A Comparative Study to Tissue Specimens
Authors: Akahane Toshiaki , Kitazono Ikumi , Yanazume Shintaro , Kamio Masaki , Togami Shinichi , Sakamoto Ippei , Nohara Sachio , Yokoyama Seiya , Kobayashi Hiroaki , Hiraki Tsubasa , Suzuki Shinsuke , Ueno Shinichi , Tanimoto Akihide 
Published: June 2020

Abstract
Background: Liquid-based cytology (LBC) is now a widely used method for cytologic screening and cancer diagnosis. Since the cells are fixed with alcohol-based fixatives, and the specimens are stored in a liquid condition, LBC specimens are suitable for genetic analyses. Methods: Here, we established a small cancer gene panel, including 60 genes and 17 microsatellite markers for next-generation sequencing, and applied to residual LBC specimens obtained by endometrial cancer screening to compare with corresponding formalin-fixed paraffin-embedded (FFPE) tissues. Results: A total of 49 FFPE and LBC specimens (n=24) were analyzed, revealing characteristic mutations for endometrial cancer, including PTEN, CTNNB1, PIK3CA, and PIK3R1 mutations. Eight cases had higher scores for both tumor mutation burden (TMB) and microsatellite instability (MSI), which agree with defective mismatch repair (MMR) protein expression. Paired endometrial LBC, and biopsied and/or resected FFPE tissues from 7 cases, presented almost identical mutations, TMB, and MSI profiles in all cases. Conclusion: These findings demonstrate that our ad hoc cancer gene panel enabled the detection of therapeutically actionable gene mutations in endometrial LBC and FFPE specimens. Endometrial cancer LBC specimens offer an alternative and affordable source of molecular testing materials.
Plantar pressure sensors indicate women to have a significantly higher peak pressure on the hallux, toes, forefoot, and medial of the foot compared to men
Authors: Yamamoto Tetsuya , Hoshino Yuichi , Kanzaki Noriyuki , Nukuto Koji , Yamashita Takahiro , Ibaraki Kazuyuki , Nagai Kanto , Nagamune Kouki , Araki Daisuke , Matsushita Takehiko , Kuroda Ryosuke 
Published: June 2020

Abstract
Background: Sex-related differences of plantar pressure distribution during activities should be thoroughly inspected as it can help establish treatment and prevention strategies for foot and ankle problems. In-shoe measurement systems are preferable without space and activity restrictions; however, previously reported systems are still heavy and bulky and induce unnatural movement. Therefore, a slim and light plantar pressure sensor was newly developed to detect the effect of sex difference on plantar pressure during standing and walking.Methods: One-hundred healthy adult volunteers (50 women and 50 men) were recruited. Ten plantar pressure sensors were implanted in a 1-mm thick insole, with a total weight of 29 g. Plantar pressure was recorded with 200 Hz during 3 seconds of standing and while walking 10 steps. The maximum loads during standing and walking were analyzed in each sensor, and the results were compared between different areas of the foot in the antero-posterior direction and the medio-lateral direction and between different time points. The movement of the center of pressure (COP) during walking was also evaluated. Analyses were adjusted for body mass index and gait speed.Results: The movement of COP was constant for both sexes. In all cases, the maximum load was observed on the medial of the foot. Women had a significantly higher peak pressure on the hallux, toes, forefoot, and medial aspect of the foot compared to men while standing and walking (p < .05).Conclusions: A newly introduced in-shoe plantar pressure sensor demonstrated a typical loading transition pattern of the foot. Furthermore, higher plantar pressure in the forefoot was detected in healthy women as compared to men during standing and walking activities.