bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Treatment of Cytokine Release Syndrome with IL-6 Blockade in a Patient Transitioning from Immune-Checkpoint to MEK/BRAF Inhibition: A Case Report and Review of Literature
Authors: Amlani Adam , Barber Claire , Fifi-Mah Aurore , Monzon Jose 
Published: April 2020

Abstract
There are now multiple targeted and immunotherapies available for the treatment of metastatic melanoma. Although these agents have dramatically improved the survival of patients, the appropriate sequencing and the safety during the transition between these drugs remains unknown. Recently two cases of cytokine release syndrome (CRS) following transition from immune-checkpoint inhibitors to BRAF and MEK inhibitors (BRAFi/MEKi) in patients with metastatic melanoma have been reported. CRS is a systemic cytokine-driven inflammatory reaction, previously well reported in chimeric antigen receptor T-cell therapies for hematologic malignancies. Here, we report a third case in which severe CRS resistant to glucocorticoid therapy following transition to a MEKi/BRAFi was treated successfully with tocilizumab, an interleukin-6 (IL-6) inhibitor. CRS should be on the differential diagnosis of immune-related adverse events of immunotherapies or targeted cancer therapies for metastatic melanoma, and clinicians in multiple disciplines should be aware of this rare complication and the potential benefits of IL-6 blockade.
KETAHANAN MULUR BAJA SUS 304 HASIL PELAPISAN METAL MATRIX COMPOSITE NiCr+ Cr3C2 DENGAN METODA HVOF
Authors: Naufal Muhammad Luthfi , Waldi Muhammad , Prajitno Djoko Hadi 
Published: April 2020

KETAHANAN MULUR DAN OKSIDASI SIKLIK BAJA SUS 304 HASIL PELAPISAN METAL MATRIX COMPOSITE NiCr+Cr3C2 DENGAN METODA HVOF. Telah dilakukan proses deposisi Metal Matrix Composite coating 60% NiCr + 30% Cr3C2+ 10% Al2O3 dan 60% NiCr + 40% Cr3C2 dengan menggunakan teknik High Velocity Oxygen Fuel (HVOF) Thermal Spray Coating, pada permukaan baja SUS 304. Tujuan pelapisan untuk meningkatkan ketahanan mulur dan oksidasi siklik dalam aplikasi pipa boiler tubes PLTU. Pengujian creep telah dilakukan pada temperatur 550oC dengan pembebanan sebesar 0.4 σy dan 0.6 σy (yield strength) selama 30240 menit (21 hari). Pengujian oksidasi siklik dengan variasi temperatur 600oC, 700oC dan 800oC selama 1 jam dalam tubes furnace dan pendinginan diluar selama 15 menit dalam 1 siklus dan di lakukan sebanyak 5 siklus. Spesimen coating Metal Matrix Composite (MMC) 3 komponen merupakan coating yang rekomendasikan dalam aplikasi pipa boiler tubes PLTU merupakan laju mulur yang paling rendah sebesar 0.000148917%/jam. Spesimen coating MMC 3 komponen pada temperatur 600oC memiliki perubahan berat oksida, ketebalan coating, dan senyawa oksida yang terbentuk paling rendah.Kata kunci: SUS 304, HVOF Thermal Spray Coating, Metal Matrix Composite, ketahanan mulur, oksidasi siklik.
A study on ocular manifestations of skin disorders- At a tertiary care centre
Authors: Siddiqua Hajira , Chowdary Sowmya 
Published: April 2020

To study the prevalence, ocular manifestations and also analyse the frequency and distribution of the potential sight threatening lesions in the various type of common skin disorders at tertiary care centre. 40 patients were studied in the Department of ophthalmology from January 2019 to December 2019. Of the 40 patients that were included in our study,12(30%) had Neurofibromatosis type-1,10(25%) patients had Psoriasis,8(20%) patients had Steven-Johnson syndrome,6(15%) patients had herpes Zoster ophthalmicus and 4(10%) patients ocular cicatricial pemphigoid. Neurofibromatosis type-1 was found to be more common among males and 50% patients presented within the age group of 21-40 years of age. Lisch nodules were seen in all the patients with neurofibromatosis type-1 and nodular neurofibromas were seen 91.7% patients.Conjunctival freckles and sphenoid wing dysplasia were seen in 1 patient Patients with Psoriasis showed a male predominance accounting for 60% whereas female accounted for 40%.the commonest age group affected by psoriasis 21-40 years seen in 60% of the patients. Among the patients with psoriasis, blepharoconjucntivitis was the most common manifestation seen in 5(50%) patients followed by keratoconjuntivitis sicca in 3(30%) patients and chronic anterior uveitis in 2(20%) patients Male preponderance was noted in patients with Steven-Johnson syndrome and majority (62.5%) of the patients were in the age group of 21-40 years. Bilateral, symmetrical involvement was seen in 87.5% of patients with Steven-Johnson syndrome.Drugs were the most common etiological agent seen in 62.5% of patients. Lid manifestations werebthe most common among those with Stevens-Johnson syndrome accounting for 62.5% patients. Males dominated the clinical scenario among the patients with herpes zoster ophthalmicus accounting for 66.67% of patients with a peak during 21-40 years of age. Preceding the eruption, pain was the commonest prodromal symptom seen in 50% patients followed by burning sensation and fever. Females were affected in 75% patients with ocular cicatricial premhigoid and they presented beyond 60 years of age with conjunctivitis in 50% patients followed by entropion and trichiasis.We conclude that, ocular involvement in skin disease is an common feature could be major component for the development of various systemic skin disorders.
As finalidades do orçamento na influência do isomorfismo institucional na autorrejeição
Authors: Pereira da Luz Igor , Eduardo Facín Lavarda Carlos 
Published: April 2020

O presente trabalho teve por objetivo examinar a influência do isomorfismo institucional na autorrejeição ao orçamento, mediada pelas finalidades do artefato. Aponta-se a importância do estudo do setor farmacêutico brasileiro pois este representa um exemplo peculiar de discussão institucional, considerando as pressões de isomorfismo institucional sofridas pelo setor. O estudo é descritivo, de abordagem quantitativa, caracterizado como pesquisa de levantamento, tipo survey. Para cumprir o objetivo foram utilizados os pressupostos de DiMaggio e Powell (1983), as respostas estratégicas de desafiar e manipular do modelo conceitual de Oliver (1991) e as finalidades do orçamento utilizadas por Ekholm e Wallin (2011). A população selecionada foram os gerentes das empresas do setor farmacêutico vinculadas ao Guia da Farmácia, e a amostra final foi composta por 147 respostas válidas. Para a análise de dados foi utilizada a Modelagem de Equações Estruturais. Os resultados apontam para uma influência positiva do isomorfismo institucional nas finalidades de planejamento e diálogo. Não foi encontrada, porém, influência das finalidades do orçamento na autorrejeição. O isomorfismo institucional ainda apresentou influência positiva na autorrejeição do orçamento. Como contribuições, o estudo traz indícios de que os fatores de isomorfismo levam a uma melhor utilização das finalidades do orçamento, levam também a uma rejeição do artefato, que pode estar ligada a fatores de multiplicidade e restrição.
Bitácora
Authors: Gaitán D. Hernando 
Published: April 2020

Hace ya cinco años al llegar a la dirección de la Revista, nos trazamos el objetivo de lograr que ésta fuera incluida en las bases de datos electrónicas más importantes a nivel internacional y nacional.En este sentido se dieron los pasos necesarios con el propósito de cumplir con los requisitos de las bases más importantes. Se ha cumplido con los requisitos de las bases Scielo Colombia - Bireme OPS y Publindex de Colciencias.En relación al proyecto a Scielo - Bireme OPS se encuentran digitados 24 números en el ambiente Scielo. La segunda publicación con mas números digitados es la Revista Colombiana de Cardiología. Falta que por lo menos que cuatro revistas colombianas tengan al menos seis números digitados para quedar incluidos en la página principal del proyecto Scielo (http://www.scielo.org/index.php?lang=en). Por ahora se puede acceder a la revista desde la página http://www.col.ops-oms.org/iah/ y desde la página principal de la Biblioteca Virtual de la Salud - Bireme http://www.bireme.br/bvs/I/ihome.htm.
Prevalence and Determinants of Malaria Infection Among Children of local farmers in Central Malawi
Authors: Chilanga Emmanuel , Collin-Vezina Delphine , MacIntosh Heather , Mitchel Claudia , Cherney Katrina 
Published: April 2020

Abstract
Background: Malaria is a leading cause of morbidity and mortality among children under five in Malawi. Children from rural areas of central Malawi have a high burden of malaria morbidity compared to other regions. The goal of this study was to examine the prevalence and determinants of malaria infection among children in rural areas of the Dowa district in central Malawi.Methods: A multistage cross-sectional study design was used to systematically sample 523 child‑mother dyads from postnatal clinics. A survey was administered to mothers to collect quantitative data, and rapid diagnostic tests were used to test for malaria infection in children. The main outcome was positive malaria diagnostic tests in children. Logistic regressions were used to determine risk factors associated with malaria among children aged 2 to 59 months.Results: The prevalence of malaria among children under five years was 35.4%. The results of the multivariate analyses showed that children of mothers who experienced recent intimate partner violence (IPV) were more likely to be diagnosed with malaria (AOR: 1.88, 95% CI: 1.19–2.97; P = 0.007) than children of mothers who did not. Children of mothers who had no formal education were more likely to be diagnosed with malaria (AOR: 2.77, 95% CI: 1.24–6.19; P = 0.013) than children of mothers who had received secondary education. In addition, children in the age ranges of 2 to 5 months and 6 to 11 months were less likely to be diagnosed with malaria (AOR: 0.21, 95% CI: 0.10–0.46; P = 0.000 and AOR: 0.43; 95% CI: 0.22–0.85; P = 0.016, respectively) than children in the age range of 24 to 59 months. Conclusion: The study found that the prevalence of malaria infection among children in the study area was comparable to the national level. We propose that in addition to available malaria control programs, further attention should be paid to children whose mothers have no formal education, children aged 24 to 59 months and mothers that are exposed to IPV in the area.
Two splice variants of the DsMEK1 mitogen-activated protein kinase kinase (MAPKK) are involved in salt stress regulation in Dunaliella salina in different ways
Authors: Tang Ziyi , Cao Xiyue , Zhang Yiping , Jiang Jia , Qiao Dairong , Xu Hui , Cao Yi 
Published: April 2020

Abstract
Background: Dunaliella salina can produce glycerol under salt stress, and this production can quickly adapt to changes in external salt concentration. Notably, glycerol is an ideal energy source. In recent years, it has been reported that the mitogen-activated protein kinase cascade pathway plays an important role in regulating salt stress, and in Dunaliella tertiolecta DtMAPK can regulate glycerol synthesis under salt stress. Therefore, it is highly important to study the relationship between the MAPK cascade pathway and salt stress in D. salina and modify it to increase the prodution of glycerol. Results: In our study, we identified and analysed the alternative splicing of DsMEK1 (DsMEK1-X1, DsMEK1-X2) from the unicellular green alga D. salina. DsMEK1-X1 and DsMEK1-X2 were both localized in the cytoplasm. qRT-PCR assays showed that DsMEK1-X2 was induced by salt stress. Overexpression of DsMEK1-X2 revealed a higher increase rate of glycerol production compared to the control and DsMEK1-X1-oe under salt stress. Under salt stress, the expression of DsGPDH2/3/5/6 increased in DsMEK1-X2-oe strains compared to the control. This finding indicated that DsMEK1-X2 was involved in the regulation of DsGPDH expression and glycerol overexpression under salt stress. Overexpression of DsMEK1-X1 increased the proline content and reduced the MDA content under salt stress, and DsMEK1-X1 was able to regulate oxidative stress; thus, we hypothesized that DsMEK1-X1 could reduce oxidative damage under salt stress. Yeast two-hybrid analysis showed that DsMEK1-X2 could interact with DsMAPKKK1/2/3/9/10/17 and DsMAPK1; however, DsMEK1-X1 interacted with neither upstream MAPKKK nor downstream MAPK. DsMEK1-X2-oe transgenic lines increased the expression of DsMAPKKK1/3/10/17 and DsMAPK1, and DsMEK1-X2-RNAi lines decreased the expression of DsMAPKKK2/10/17. DsMEK1-X1-oe transgenic lines did not exhibit increased gene expression, except for DsMAPKKK9. Conclusion: Our findings demonstrate that DsMEK1-X1 and DsMEK1-X2 can respond to salt stress by two different pathways. The DsMEK1-X1 response to salt stress reduces oxidative damage; however, the DsMAPKKK1/2/3/9/10/17- DsMEK1-X2-DsMAPK1 cascade is involved in the regulation of DsGPDH expression and thus glycerol synthesis under salt stress.
Regional education on endoscopic surgery using a teleconference system with high-quality video via the internet: Saga surgical videoconferences
Authors: Manabe Tatsuya , Takasaki Mitsuhiro , Ide Takao , Kitahara Kenji , Sato Seiji , Yunotani Seiji , Hirohashi Yoshimi , Iyama Akihiro , Taniguchi Masahiko , Ogata Toshiro , Shimizu Shuji , Noshiro Hirokazu 
Published: April 2020

Abstract
Background: Effective education about endoscopic surgery (ES) is greatly needed for unskilled surgeons, especially at low-volume institutions, to maintain the safety of patients. We have tried to establish the remote educational system using videoconference system through the internet for education about ES to surgeons belonging to affiliate institutions. The aim of this manuscript was to report the potential to establish a comfortable remote educational system and to debate its advantages.Methods: We established a local remote educational conference system by combining the use of a general web conferencing system and a synchronized remote video playback system with annotation function through a high-speed internet.Results: During 2014–2019, we conducted 14 videoconferences to review and improve surgeons’ skills in performing ES at affiliated institutions. At these conferences, while an uncut video of ES that had been performed at one of the affiliated institutions was shown, the surgical procedure was discussed frankly, and expert surgeons advised improvements. The annotation system is useful for easy, prompt recognition among the audience regarding anatomical structures and procedures that are difficult to explain verbally.Conclusions: This system is of low initial cost and offers easy participation and high-quality videos. It would therefore be a useful tool for regional ES education.
Estimating the effect of adjuvant chemo-therapy for colon-cancer using registry data: a method comparison and validation
Authors: Shen Lingjie , Visser Erik , Wilt Hans de , Verheul Henk , Erning Felice van , Geleijnse Gijs , Kaptein Maurits 
Published: April 2020

Abstract
Background: Although randomized controlled trials (RCT) are the gold standard to estimate treatment effects, they are often criticized in terms of generalizability. Observational data might alleviate this problem by being readily available in large quantities. However, observational data are potentially confounded. In this methodological study we use a large-scale RCT as the gold standard to examine the performance of various statistical methods to control for potential confounding in observational data. Methods: In this paper we compare three types of methods that allow researchers to correct for such potential confounding: direct methods, inverse probability weighting (IPW) methods and doubly robust (DR) methods. We uniquely compare estimates obtained from the population-wide Netherlands Cancer Registry (NCR) on colon cancer (n=52621) with estimates obtained from a large-scale RCT. As the RCT differs from the observational data both in its sampling mechanism and in its treatment assignment mechanism, we first resample the NCR data to reflect the distribution in RCT data. Next, we correct for potential confounding using three alternative types of methods and consequentially evaluate their estimates to those obtained in the RCT. Results: We find that while all estimators qualitatively approximate to findings in the RCT, methods that can flexibly model the response (i.e., direct estimation and DR estimation) performed consistently superior to the inverse propensity score method. Subgroup analysis indicates that relatively simple models allow us to properly estimate the treatment effect. However, these simple models do not properly identify heterogeneous treatment effects in stage2 colon cancer. Careful sensitivity analysis using more flexible models demonstrates both the uncertainty and the potential heterogeneous treatment effect in stage2 cancer and provides robust estimation of treatment effect in stage3 cancer. Conclusions: Our results suggest that both the direct method and the DR method, when executed with care, can be used to reliably estimate treatment effects based on registry data. This methodological validation opens the door to more extensive use of registry data for the estimation of (individual) treatment effects. Additionally, our identification of potentially meaningful subgroups of stage2 colon cancer patients who, based on our analysis seem to benefit from chemotherapy, should be further explored.
Apatinib combined with temozolomide in the treatment of recurrent glioblastomas: an exploratory study
Authors: Li Tianyuan , Wu Hui , Hai Long , Hong Xitian , Sun Xueming , Huang Rong , Wang Yan , Liu Wen hang 
Published: April 2020

Abstract
Background

Glioblastoma (GBM) is the most common primary malignant brain tumor with poor prognosis. At present, there is no standard treatment for GBM who failed first-line treatment. Apatinib is a new type of oral small molecule angiogenesis inhibitor. The goals of this study are to research the curative effect, side effects and changes of immune factors and cytokines of treatment with Apatinib combined with TMZ (NCT:04253873).
Methods

12 patients with recurrent GBM who failed first-line treatment were treated with apatinib combined with TMZ. They received oral apatinib (500 mg/day) in conjunction with TMZ (150 mg/m2/day). Contrast-enhanced MRI was performed every 4 weeks before and after treatment to measure the tumor volume. The peripheral blood samples were collected and the expressions of soluble PD-1(sPD-1), soluble PD-L1(sPD-L1), IL-6 and IL-10 in peripheral blood were detected by ELISA.
Results

The objective effective rate (ORR) was 41.67% (5/12). The disease control rate (DCR) was 75% (9/12). The median progression-free survival (m PFS) time was 6 months. The 6-month PFS rate was 50%. The most common adverse events were Hypertension and Fatigue. In our study, we did hematological analysis on 5 patients out of 12, we found that the plasma expression of sPD-L1 decreased and the expression of sPD-1 increased in the patients with significant reduced tumor volume, which may be related to longer survival and better prognosis, While the expressions of sPD-L1 increased and sPD-1 decreased in some patients with enlarged tumor volume, which may be related to shorter survival and worse prognosis. The expression levels of IL-6 and IL-10 in blood showed variation in patients with different tumor volume change. And the expression levels of △sPD-1, △sPD-L1, △IL-6 showed significant correlations to the tumor volume changes (△volume) (r=-0.651, p = 0.002; r = 0.898, p < 0.0001; r = 0.463, p = 0.040).The changes in △IL-10 were not correlated with tumor volume changes (△volume ) (r = 0.408, p = 0.074).
Conclusion

Apatinib combined with TMZ is safe and effective in the treatment of recurrent GBM. This study showed that immune factors (sPD-1, sPD-L1) may be potential prognostic biomarkers for GBM patients.
Education Level may Modify the Association Between Cardiac Index and Cognitive Function Among Elders with Normal Ejection Function
Authors: CHUANG shao-yuan , CHENG Hao-Min , KO Yu-Ting , LIAO Chao-Feng , PAN WEN-Hern , LIU Wen-Ling , HUNG Chen-Ying , CHEN Chen-Huan 
Published: April 2020

Abstract

Background Lower cardiac index (CI) in elders has been associated with incident dementia, and higher CI has protectively effect with brain aging. In the present study, we investigated the modulating effects of education level and arterial stiffness on the association between CI and cognitive function among older adults.Methods A total of 723 elders(≥ 60 years, 50.1% female) with normal left ventricular ejection-fraction (≥50%) were identified from the Cardiovascular Diseases Risk Factor Two-Township Study. CI was calculated from the Doppler-derived stroke volume. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity(CFPWV) and global cognitive function by using the Mini-Mental Short Examination(MMSE). Education level was determined by years of formal education.Results In linear regression analysis adjusting for age, sex, formal years of education and CFPWV, CI was significantly positively associated with MMSE (BETA = 0.344±0.130,P = 0.0082). In logistic regression analysis adjusting for age, sex, formal years of education and CFPWV, subjects with a CI≥75 percentile had a significantly lower risk of low MMSE (< 26)(OR = 0.495,95%CI = 0.274–0.896,P = 0.02). In subgroup analysis, higher CI was significantly associated with higher MMSE and lower risk of low MMSE only in elders with ≤9 years of formal education. Causal mediation analysis suggests that higher CI maintains higher MMSE in elders with lower education levels whereas higher CFPWV causes lower MMSE in all elders.Conclusion In elders with normal ejection fraction, a higher CI was associated with a lower risk of cognitive function impairment, independent of arterial stiffness, mainly in subjects with a lower education level and possibly a smaller cognitive reserve.
The Career Choice, Motivation and Future Expectations of Dental Students: A Mixed Method Analysis
Authors: Khalaf Mai E , Abubakr Neamat H , Al-Enezi Hanadi , Ziada Hassan 
Published: April 2020

Abstract
Background An insight into students’ motivation and choice into entering and remaining in dental education is essential. The understanding of how choices are made will help universities in the planning of admission policies. The aim of this study was to evaluate the career choice and motivation into dental education by undergraduate dental students at the Faculty of Dentistry, Kuwait University. Methods A mixed-method design was employed, evaluating both quantitative and qualitative data. One hundred seventy-three questionnaires were distributed to all registered dental students, with a response rate of 85%. Seven focus groups were facilitated, and related data recorded and transcribed. Results The mother’s influence was statistically significant in decision making. There was a statistically significant relationship between motivation to choose dentistry and personal decision. Qualitatively, major influencers were family and culture.Conclusions While students were confident in their choice of career; this confidence was not reflected until the more advanced clinical stages of their dental education.