bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventive replacement with defaulting
Authors: Alotaibi N M , Cavalcante C A V , Lopes R S , Scarf P A 
Published: January 2020

Abstract
This paper models age replacement and block replacement when there is the possibility of defaulting on the planned maintenance. A default occurs when a planned preventive replacement is not executed, and we discuss how defaults can arise in practice. Our aim is to study the robustness of block replacement and age replacement, bearing in mind that (a) these policies are frequently used in practice, (b) in the standard scenario (no defaulting) age replacement has a lower economic cost rate than block-replacement and (c) block replacement is simple to manage because component age does not have to be monitored. We model defaults as independent Bernoulli trials. We prove that a cost-minimizing critical age for replacement in the age policy with defaulting exists if the time to failure distribution has an increasing failure rate. A numerical study of the policies indicates that: age replacement is effective if maintenance control is good, that is, when there is only a small chance of defaulting; block replacement is relatively robust to defaulting (postponement), but less so to lack of knowledge about component reliability.
Side Deposit with Regular Texture Food for Clinical Cases In-Home
Authors: Taylor Tessa 
Published: January 2020

Abstract
Objective Research has shown effectiveness of nonremoval of the spoon and physical guidance in increasing consumption and decreasing inappropriate mealtime behavior. The side deposit has been used to treat passive refusal in 2 studies (1 in a highly specialized hospital setting) using lower manipulated-texture foods on an infant gum brush. Methods We extended the literature by using regular texture bites of food with a finger prompt and side deposit (placing bites inside the side of the child’s mouth via the cheek) in an intensive home-based program setting in Australia, demonstrating that attention and tangible treatments alone were ineffective prior, fading the tangible treatment, showing caregiver training, and following up. 2 male children with autism spectrum disorder (with texture/variety selectivity; one with liquid dependence) participated in their homes. We used a reversal design to replicate effectiveness of the side deposit added to a treatment package. Results For both participants, we observed a &gt;98% decrease in latency to acceptance, a 100% decrease in inappropriate mealtime behavior, and a 100% increase in consumption with the side deposit added. Variety was increased to over 85 regular texture foods. 100% of admission goals were met. Caregivers were trained to high procedural integrity and the protocol was generalized to school and the community. Gains maintained to 3 and 1.5 years. Conclusion This is important work in adding to the literature and support for the side deposit and expanding to regular texture, as well as replicating and extending empirically supported treatments for feeding internationally to the home setting.
Infrared properties of planetary nebulae with [WR] and wels central stars
Authors: Muthumariappan C , Parthasarathy M 
Published: January 2020

ABSTRACT
We report the infrared (IR) properties of planetary nebulae (PNe) with Wolf–Rayet (WR) type and wels central stars known to date and compare them with the IR properties of a sample of PNe with H-rich central stars. We use near-, mid-, and far-IR photometric data from archives to derive the IR properties of PNe. We have constructed IR colour–colour diagrams of PNe using measurements from 2MASS, IRAS, WISE, and Akari bands. [WR] PNe have a larger near-IR emission from the hot dust component and also show a tendency for stronger 12 μm emission as compared to the other two groups. Cool asymptotic giant branch dust properties of all PNe are found to be similar. We derived the dust colour temperatures, dust masses, dust-to-gas mass ratios, IR luminosities, and IR excess (IRE) of PNe for these three groups. [WR] PNe and wels-PNe tend to have larger mean values for dust mass when compared to the third group. The average dust-to-gas mass ratio is found to be similar for the three groups of PNe. While there is a strong correlation of dust temperature and IR luminosity with the age for the three groups of PNe, the dust mass, dust-to-gas mass ratios, and IRE are found to be non-varying as the PNe evolve. [WR] PNe and wels-PNe show very similar distribution of excitation classes and also show similar distribution with Galactic latitude.
A complete catalogue of dusty supernova remnants in the Galactic plane
Authors: Chawner H , Gomez H L , Matsuura M , Smith M W L , Papageorgiou A , Rho J , Noriega-Crespo A , De Looze I , Barlow M J , Cigan P , Dunne L , Marsh K 
Published: January 2020

ABSTRACT
We search for far-infrared (FIR) counterparts of known supernova remnants (SNRs) in the Galactic plane (360° in longitude and $b = \pm \, 1^{\circ }$) at 70–500 μm with Herschel. We detect dust signatures in 39 SNRs out of 190, made up of 13 core-collapse supernovae (CCSNe), including 4 Pulsar Wind Nebulae (PWNe), and 2 Type Ia SNe. A further 24 FIR detected SNRs have unknown types. We confirm the FIR detection of ejecta dust within G350.1−0.3, adding to the known sample of ∼ 10 SNRs containing ejecta dust. We discover dust features at the location of a radio core at the centre of G351.2+0.1, indicating FIR emission coincident with a possible Crab-like compact object, with dust temperature and mass of Td = 45.8 K and Md = 0.18 M⊙, similar to the PWN G54.1+0.3. We show that the detection rate is higher among young SNRs. We produce dust temperature maps of 11 SNRs and mass maps of those with distance estimates, finding dust at temperatures $15\, \lesssim \, T_d\, \lesssim \, 40$ K. If the dust is heated by shock interactions the shocked gas must be relatively cool and/or have a low density to explain the observed low grain temperatures.
ExoMol molecular line lists – XXXVII. Spectra of acetylene
Authors: Chubb Katy L , Tennyson Jonathan , Yurchenko Sergei N 
Published: January 2020

ABSTRACT
A new ro-vibrational line list for the ground electronic state of the main isotopologue of acetylene, 12C2H2, is computed as part of the ExoMol project. The aCeTY line list covers the transition wavenumbers up to 10 000 cm−1 (λ &gt; 1 $\mu$m), with lower and upper energy levels up to 12 000 and 22 000 cm−1 considered, respectively. The calculations are performed up to a maximum value for the vibrational angular momentum, Kmax = Lmax = 16, and maximum rotational angular momentum, J = 99. Higher values of J were not within the specified wavenumber window. The aCeTY line list is considered to be complete up to 2200 K, making it suitable for use in characterizing high-temperature exoplanet or cool stellar atmospheres. Einstein-A coefficients, which can directly be used to calculate intensities at a particular temperature, are computed for 4.3 billion (4 347 381 911) transitions between 5 million (5 160 803) energy levels. We make comparisons against other available data for 12C2H2, and demonstrate this to be the most complete line list available. The line list is available in electronic form from the online CDS and ExoMol data bases.
Search for L5 Earth Trojans with DECam
Authors: Markwardt Larissa , Gerdes D W , Malhotra R , Becker J C , Hamilton S J , Adams F C 
Published: January 2020

ABSTRACT
Most of the major planets in the Solar system support populations of co-orbiting bodies, known as Trojans, at their L4 and L5 Lagrange points. In contrast, Earth has only one known co-orbiting companion. This paper presents the results from a search for Earth Trojans (ETs) using the DECam instrument on the Blanco Telescope at CTIO. This search found no additional Trojans in spite of greater coverage compared to previous surveys of the L5 point. Therefore, the main result of this work is to place the most stringent constraints to date on the population of ETs. These constraints depend on assumptions regarding the underlying population properties, especially the slope of the magnitude distribution (which in turn depends on the size and albedo distributions of the objects). For standard assumptions, we calculate upper limits to a 90 per cent confidence limit on the L5 population of NET &lt; 1 for magnitude H &lt; 15.5, NET = 60–85 for H &lt; 19.7, and NET = 97 for H = 20.4. This latter magnitude limit corresponds to Trojans ∼300 m in size for albedo 0.15. At H = 19.7, these upper limits are consistent with previous L4 ET constraints and significantly improve L5 constraints.
And yet it flips: connecting galactic spin and the cosmic web
Authors: Kraljic Katarina , Davé Romeel , Pichon Christophe 
Published: January 2020

ABSTRACT
We study the spin alignment of galaxies and haloes with respect to filaments and walls of the cosmic web, identified with DisPerSE , using the Simba simulation from z = 0 − 2. Massive haloes’ spins are oriented perpendicularly to their closest filament’s axis and walls, while low-mass haloes tend to have their spins parallel to filaments and in the plane of walls. A similar mass-dependent spin flip is found for galaxies, albeit with a weaker signal particularly at low mass and low-z, suggesting that galaxies’ spins retain memory of their larger scale environment. Low-z star-forming and rotation-dominated galaxies tend to have spins parallel to nearby filaments, while quiescent and dispersion-dominated galaxies show preferentially perpendicular orientation; the star formation trend can be fully explained by the stellar mass correlation, but the morphology trend cannot. There is a dependence on HI mass, such that high-HI galaxies tend to have parallel spins while low-HI galaxies are perpendicular, suggesting that HI content may trace anisotropic infall more faithfully than the stellar component. Finally, at fixed stellar mass, the strength of spin alignments correlates with the filament’s density, with parallel alignment for galaxies in high density environments. These findings are consistent with conditional tidal torque theory, and highlight a significant correlation between galactic spin and the larger scale tides that are important e.g., for interpreting weak lensing studies. Simba allows us to rule out numerical grid locking as the cause of previously-seen low mass alignment.
Searching for ultra-fast outflows in AGN using variability spectra
Authors: Igo Z , Parker M L , Matzeu G A , Alston W , Alvarez Crespo N , Fürst F , Buisson D J K , Lobban A , Joyce A M , Mallick L , Schartel N , Santos-Lleó M 
Published: January 2020

ABSTRACT
We present a qualitative search for ultra-fast outflows (UFOs) in excess variance spectra of radio-quiet active galactic nuclei (AGNs). We analyse 42 sources from the spectroscopic UFO detection sample, and an additional 22 different sources from the variability sample. A total of 58 sources have sufficient observational data from XMM–Newton EPIC-pn and variability for an excess variance spectrum to be calculated. We examine these spectra for peaks corresponding to variable blue-shifted H- and He-like ion absorption lines from UFOs. We find good evidence for such outflows in 28 per cent of the AGN sample and weak evidence in a further 31 per cent, meaning that ∼30–60 per cent of the AGN sample hosts such UFOs. The mean and median blue-shifted velocity is found to be ∼0.14c and 0.12c, respectively. Current variability methods allow for a fast, model-independent determination of UFOs; however, further work needs to be undertaken to better characterize the statistical significance of the peaks in these spectra by more rigorous modelling. Detecting good evidence for variable UFO lines in a large number of sources also lays the groundwork for detailed analysis of the variability time-scales of the absorbers. This will allow us to probe their densities and hence distances from the central supermassive black hole.
Vortex pinning in the superfluid core of neutron stars and the rise of pulsar glitches
Authors: Sourie Aurélien , Chamel Nicolas 
Published: January 2020

ABSTRACT
Timing of the Crab and Vela pulsars has recently revealed very peculiar evolutions of their spin frequency during the early stage of a glitch. We show that these differences can be interpreted from the interactions between neutron superfluid vortices and proton fluxoids in the core of these neutron stars. In particular, pinning of individual vortices to fluxoids is found to have a dramatic impact on the mutual friction between the neutron superfluid and the rest of the star. The number of fluxoids attached to vortices turns out to be a key parameter governing the global dynamics of the star. These results may have implications for the interpretation of other astrophysical phenomena such as pulsar-free precession or the r-mode instability.
Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a
Authors: Creutzburg Sjoerd C A , Wu Wen Y , Mohanraju Prarthana , Swartjes Thomas , Alkan Ferhat , Gorodkin Jan , Staals Raymond H J , van der Oost John 
Published: January 2020

AbstractGenome editing has recently made a revolutionary development with the introduction of the CRISPR–Cas technology. The programmable CRISPR-associated Cas9 and Cas12a nucleases generate specific dsDNA breaks in the genome, after which host DNA-repair mechanisms can be manipulated to implement the desired editing. Despite this spectacular progress, the efficiency of Cas9/Cas12a-based engineering can still be improved. Here, we address the variation in guide-dependent efficiency of Cas12a, and set out to reveal the molecular basis of this phenomenon. We established a sensitive and robust in vivo targeting assay based on loss of a target plasmid encoding the red fluorescent protein (mRFP). Our results suggest that folding of both the precursor guide (pre-crRNA) and the mature guide (crRNA) have a major influence on Cas12a activity. Especially, base pairing of the direct repeat, other than with itself, was found to be detrimental to the activity of Cas12a. Furthermore, we describe different approaches to minimize base-pairing interactions between the direct repeat and the variable part of the guide. We show that design of the 3′ end of the guide, which is not involved in target strand base pairing, may result in substantial improvement of the guide's targeting potential and hence of its genome editing efficiency.
JASS: command line and web interface for the joint analysis of GWAS results
Authors: Julienne Hanna , Lechat Pierre , Guillemot Vincent , Lasry Carla , Yao Chunzi , Araud Robinson , Laville Vincent , Vilhjalmsson Bjarni , Ménager Hervé , Aschard Hugues 
Published: January 2020

Abstract
Genome-wide association study (GWAS) has been the driving force for identifying association between genetic variants and human phenotypes. Thousands of GWAS summary statistics covering a broad range of human traits and diseases are now publicly available. These GWAS have proven their utility for a range of secondary analyses, including in particular the joint analysis of multiple phenotypes to identify new associated genetic variants. However, although several methods have been proposed, there are very few large-scale applications published so far because of challenges in implementing these methods on real data. Here, we present JASS (Joint Analysis of Summary Statistics), a polyvalent Python package that addresses this need. Our package incorporates recently developed joint tests such as the omnibus approach and various weighted sum of Z-score tests while solving all practical and computational barriers for large-scale multivariate analysis of GWAS summary statistics. This includes data cleaning and harmonization tools, an efficient algorithm for fast derivation of joint statistics, an optimized data management process and a web interface for exploration purposes. Both benchmark analyses and real data applications demonstrated the robustness and strong potential of JASS for the detection of new associated genetic variants. Our package is freely available at https://gitlab.pasteur.fr/statistical-genetics/jass.
TP53, ATRX alterations, and low tumor mutation load feature IDH-wildtype giant cell glioblastoma despite exceptional ultra-mutated tumors
Authors: Cantero Diana , Mollejo Manuela , Sepúlveda Juan M , D’Haene Nicky , Gutiérrez-Guamán Myriam J , Rodríguez de Lope Ángel , Fiaño Concepción , Castresana Javier S , Lebrun Laetitia , Rey Juan A , Salmon Isabelle , Meléndez Bárbara , Hernández-Laín Aurelio 
Published: January 2020

Abstract

Background
Giant cell glioblastoma (gcGBM) is a rare morphological variant of IDH-wildtype (IDHwt) GBM that occurs in young adults and have a slightly better prognosis than “classic” IDHwt GBM.

Methods
We studied 36 GBMs, 14 with a histopathological diagnosis of gcGBM and 22 with a giant cell component. We analyzed the genetic profile of the most frequently mutated genes in gliomas and assessed the tumor mutation load (TML) by gene-targeted next-generation sequencing. We validated our findings using The Cancer Genome Atlas (TCGA) data.

Results
p53 was altered by gene mutation or protein overexpression in all cases, while driver IDH1, IDH2, BRAF, or H3F3A mutations were infrequent or absent. Compared to IDHwt GBMs, gcGBMs had a significant higher frequency of TP53, ATRX, RB1, and NF1 mutations, while lower frequency of EGFR amplification, CDKN2A deletion, and TERT promoter mutation. Almost all tumors had low TML values. The high TML observed in only 2 tumors was consistent with POLE and MSH2 mutations. In the histopathological review of TCGA IDHwt, TP53-mutant tumors identified giant cells in 37% of the cases. Considering our series and that of the TCGA, patients with TP53-mutant gcGBMs had better overall survival than those with TP53wt GBMs (log-rank test, P &lt; .002).

Conclusions
gcGBMs have molecular features that contrast to “classic” IDHwt GBMs: unusually frequent ATRX mutations and few EGFR amplifications and CDKN2A deletions, especially in tumors with a high number of giant cells. TML is frequently low, although exceptional high TML suggests a potential for immune checkpoint therapy in some cases, which may be relevant for personalized medicine.
Respiratory health, occupation and the healthy worker effect
Authors: Senthilselvan A , Coonghe W V L , Beach J 
Published: January 2020

AbstractBackgroundWorkers are exposed to physical, chemical and other hazards in the workplace, which may impact their respiratory health.AimsTo examine the healthy worker effect in the Canadian working population and to identify the association between occupation and respiratory health.MethodsData from four cycles of the Canadian Health Measures Survey were utilized. The current occupation of employed participants was classified into 10 broad categories based on National Occupation Category 2011 codes. Data relating to 15 400 subjects were analysed.ResultsA significantly lower proportion of those in current employment than those not in current employment reported respiratory symptoms or diseases or had airway obstruction. Similarly, those currently employed reported better general health and had greater mean values for percent-predicted forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow between 25% and 75% of FVC (FEF25–75%) and FEV1/FVC ratio. Among males, females and older age groups, significant differences were observed for almost all the respiratory outcomes for those in current employment. Those in ‘Occupations unique to primary industry’ had a significantly greater likelihood of regular cough with sputum and ever asthma and had lower mean values of percent-predicted FEV1/FVC and FEF25–75% than those in ‘Management occupations’. Those in ‘Health occupations’ had the highest proportion of current asthma.ConclusionsParticipants in current employment were healthier than those not in current employment providing further support for the healthy worker effect. Those in ‘Occupations unique to primary industry’ had an increased risk of adverse respiratory outcomes and reducing workplace exposures in these occupations has the potential to improve their respiratory health.
Pain due to Ehlers-Danlos Syndrome Is Associated with Deficit of the Endogenous Pain Inhibitory Control
Authors: Leone Caterina Maria , Celletti Claudia , Gaudiano Gianfranco , Puglisi Paola Anna , Fasolino Alessandra , Cruccu Giorgio , Camerota Filippo , Truini Andrea 
Published: January 2020

Abstract

Objectives
Although pain is a common complication of the hypermobile type of Ehlers–Danlos syndrome, its underlying mechanisms are still an issue of controversy. In this psychophysical study, we aimed at testing small-fiber function and the endogenous pain inhibitory control in patients with pain due to Ehlers-Danlos syndrome.

Methods
In 22 patients with pain due to Ehlers-Danlos syndrome and 22 healthy participants, matched for age and sex, we tested small-fiber function using quantitative sensory testing and the endogenous pain inhibitory control using the conditioned pain modulation (CPM) protocol. As quantitative sensory testing methods, we included thermal pain and mechanical pain thresholds and the wind-up ratio. The CPM protocol consisted of two heat painful stimuli, that is, a test stimulus and a conditioning stimulus.

Results
All patients complained of widespread pain. Quantitative sensory testing revealed no small-fiber deficit; in the area of maximum pain, we found an increased wind-up ratio. Whereas in the healthy participants the CPM protocol showed that the test stimulus rating was significantly reduced during conditioning, in patients with pain due to hEDS, the test stimulus rating increased during conditioning.

Conclusions
Our psychophysical study showing that patients with pain due to hEDS have an increased wind-up ratio in the area of maximum pain and abnormal CPM protocol suggests that in this condition, pain is associated with central sensitization, possibly due to deficit of the endogenous pain inhibitory control. These data might be relevant to pharmacological treatment.
Macroprudential Regulation versus mopping up after the crash
Authors: Jeanne Olivier , Korinek Anton 
Published: January 2020

AbstractHow should macroprudential policy be designed when policymakers also have access to liquidity provision tools to manage crises? We show in a tractable model of systemic banking risk that there are three factors at play: first, ex post liquidity provision mitigates financial crises, and this reduces the need for macroprudential policy. In the extreme, if liquidity provision is untargeted and costless or if it completely forestalls crises by credible out-of-equilibrium lending-of-last-resort, there is no role left for macroprudential regulation. Second, however, macroprudential policy needs to consider the ex ante incentive effects of targeted liquidity provision. Third, if shadow banking reduces the effectiveness of macroprudential instruments, it is optimal to commit to less generous liquidity provision as a second-best substitute for macroprudential policy.