bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surprisingly Strong K-band Emission Found in Low-luminosity Active Galactic Nuclei
Authors: Dumont Antoine , Seth Anil C. , Strader Jay , Greene Jenny E. , Burtscher Leonard , Neumayer Nadine 
Published: December 2019

Abstract
We examine the near-infrared (NIR) emission from low-luminosity active galactic nuclei (LLAGNs). Our galaxy sample includes 15 objects with detected 2–10 keV X-ray emission, dynamical black hole mass estimates from the literature, and available Gemini/NIFS integral field spectroscopy data. We find evidence for red continuum components at the center of most galaxies, consistent with the hot dust emission seen in higher-luminosity AGNs. We decompose the spectral data cubes into a stellar and continuum component, assuming the continuum component comes from thermal emission from hot dust. We detect nuclear thermal emission in 14 out of 15 objects. This emission causes weaker CO absorption lines and redder continuum (2.05–2.28 μm) in our K-band data, as expected from hot dust around an AGN. The NIR emission is clearly correlated with the 2–10 keV X-ray flux, with a Spearman coefficient of r
spearman = 0.69 suggesting a >99% significance of correlation, providing further evidence of an AGN origin. Our sample has typical X-ray and NIR fluxes 3–4 orders of magnitude less luminous than previous work studying the NIR emission from AGNs. We find that the ratio of NIR to X-ray emission increases toward lower Eddington ratios. The NIR emission in our sample is often brighter than the X-ray emission, with our K-band AGN luminosities comparable to or greater than the 2–10 keV X-ray luminosities in all objects with Eddington ratios below 0.01%. The nature of this LLAGN NIR emission remains unclear, with one possibility being an increased contribution from jet emission at these low luminosities. These observations suggest the James Webb Space Telescope will be a useful tool for detecting the lowest-luminosity AGNs.
Les déterminants du recours au dépistage du cancer du col de l’utérus : une analyse départementale
Authors: Konopka Anne-Marie , Barnay Thomas , Billaudeau Nathalie , Sevilla-Dedieu Christine 
Published: December 2019

L’objectif de cette étude est d’analyser les déterminants des disparités géographiques de recours au dépistage du cancer du col en France. L’échantillon étudié est composé de femmes âgées de 25 à 65 ans, assurées à la Mutuelle Générale de l’Éducation Nationale (MGEN) au moins en Régime Obligatoire (RO) sur la période du 1er janvier 2012 au 31 décembre 2014. Les modèles multiniveaux confirment l’existence d’inégalités territoriales de recours au dépistage. Par ailleurs, ils montrent que l’âge, le tarif de la consultation de gynécologie et un contexte socio-économique défavorisé sont associés à une diminution de la probabilité de se faire dépister. Au contraire, le fait d’être en couple, d’être couverte en Régime Complémentaire (RC) par la MGEN, d’avoir eu un suivi pour une contraception ou une grossesse, de s’être faite dépister pour le cancer du sein (mammographie) et la densité de professionnels de santé sont associés à une augmentation du recours au dépistage. Différents leviers d’action sont discutés au regard du rôle majeur joué par les professionnels de santé dans l’accès au dépistage.
Tous les chantiers de Notre-Dame
Authors: Maurot Élodie 
Published: December 2019

Dans les flammes du 15 avril 2019, la charpente et la flèche de la cathédrale de Paris ont disparu. En France comme à l’étranger, l’émotion a été aussi vive que le brasier. Un important chantier de sécurisation du monument est en cours, puis viendra le temps de la restauration, mais faire renaître Notre-Dame ne sera pas qu’un chantier technique.
Influence des modes managériales sur la culture d’entreprise : une approche exploratoire dans le contexte camerounais
Authors: Boubakary Ben , Zerbib Romain 
Published: December 2019

Cet article propose d’illustrer l’influence des modes managériales sur la culture d’une entreprise à travers une approche sociologique de la théorie néo-institutionnelle. Il a pour objectif de comprendre par quels mécanismes un instrument de management à la mode se diffuse au sein d’une entreprise et de montrer que, une fois adoptée, la mode peut au fil du temps, modifier la culture organisationnelle selon une logique institutionnelle. Pour ce faire, des entretiens semi-directifs ont été réalisés auprès d’acteurs qui côtoient les pratiques de management en vogue, à savoir : les managers, les consultants et les universitaires. Tout en confirmant le rôle des acteurs clé dans la diffusion des modes, nous avons montré l’influence des modes managériales sur la culture d’une entreprise par l’intermédiation des facteurs institutionnels.
Doing research on doing management control dans une entreprise qui se libère, une auto-ethnographie
Authors: Duan Yuewu 
Published: December 2019

Cet article vise à contribuer à la compréhension de la mode de management « libération d’entreprise » sous l’angle contrôle organisationnel. Éclairé par le tournant pratique, ce premier point d’étape d’une recherche auto-ethnographique s’est intéressé aux pratiques, techniques et outils utilisés par une filiale d’un groupe industriel européen pour « se libérer ». Il montre comment et pourquoi le contrôle organisationnel est même au cœur de cette « libération », en restituant la mise en place des « nouveaux » contrôles et la résistance des anciens. Il révèle aussi que cette « libération » s’appuie beaucoup sur des pratiques, techniques et outils d’anciennes modes de management mainstream comme « lean management » et « empowerment », et ceux de l’Excellence Opérationnelle qui semblerait émergente et mériterait d’être analysée.
Carpal Tunnel Syndrome Due To Tophaceous Gout
Authors: Rich John T , Bush David C , Lincoski Chris J , Harrington Thomas M 
Published: December 2019

abstract
Tophaceous gout is a recognized cause of carpal tunnel syndrome. Of 2649 carpal tunnel releases, 15 hands in 13 patients were identified with tophaceous gout in the carpal tunnel. The incidence of tophaceous gout in the carpal tunnel was 0.6%. Twelve of 13 patients were male, and 8 of 10 patients with a history of gout developed carpal tunnel syndrome despite adequate medical treatment. Thus, consideration should be given for tophi as a cause of carpal tunnel syndrome, especially in older men despite medical treatment for gout.
Cervicobrachialgia and Pancoast Tumor: Value of Standard Anteroposterior Cervical Radiographs in Early Diagnosis
Authors: Villas C , Collía A , Aquerreta J D , Aristu J , Torre W , de Rada P Díaz , Gocci S 
Published: December 2019

abstract
Ten patients diagnosed with Pancoast tumor were studied retrospectively. The definitive diagnosis was made between 2 and 24 months after the onset of pain. Pain localization was hard to pinpoint; some patients reported pain in four different sites (neck, shoulder, arm, and scapula). Five patients had previously been diagnosed with degenerative, inflammatory, or infectious diseases of the cervical spine or shoulder. In the remaining five patients, the diagnosis was made during the first clinical visit. In three patients, an orthopedic surgeon made the diagnosis by viewing a standard anteroposterior (AP) cervical radiograph. The radiographic evidence arousing suspicion of a Pancoast tumor was the lack of pulmonary air at the top of the affected lung. Furthermore, a parallel study was conducted on 100 consecutive patients seeking treatment for neck pain. By examining the AP radiographs of their cervical spines, the third rib and the top of both lungs were observed in all cases. This study stresses the value of standard AP cervical radiographs in the diagnosis of Pancoast tumor.
EXPERIMENTAL ANALYSIS OF DIFFERENT INSULATED FAÇADE TECHNOLOGIES IN SUMMER CONDITION
Authors: Salvalai Graziano , Sesana Marta Maria 
Published: December 2019

ABSTRACT
At the present, the ventilated façade is one of the most widely used and most innovative systems characterized by different energy saving features, but due to its complexity, the real performances are difficult to predict by numerical analysis. This work shows the results of the monitoring campaign conducted on two Cross Laminated Timber (CLT) test boxes equipped with different thermal coat technologies to realize the performances comparisons. In particular, the investigation focus on the evaluation of surface temperatures of the different wall layers and the indoor air temperature for: i) a micro ventilated façade and ii) two different ETICS solutions. The monitoring campaign has been conducted during the summer season on walls with equivalent thermal transmittance (U-value) and different thermal capacity. In detail, the experimental work has been performed to estimate the Isotec® wall micro ventilated façade performance in comparison with two traditional ETICS technology: the first one realized with EPS and the second one with high density rock wool insulation. The results show that due to the shading effect provided by the external layer, the temperature within the cavity of the ventilate façade is reduced by 8–10 °C, reducing the cooling loads through the wall by 30–40% with respect to ETICS with EPS. The shading and the ventilation effects balance the presence of thermal insulation with less heat capacity; consequently, it validates the good quality of Isotec® as wall technology with performances comparable to ETICS solution with high density rock wool insulation.
Evaluating the accuracy of the VitalWellness device
Authors: Polanco Nicole , Odametey Sharon , Derakhshani Seyyedeh Neda , Khachaturian Mark , Devoe Connor , Jethwani Kamal , Kakarmath Sujay 
Published: December 2019

Background and Objective:
Portable and readily accessible wellness devices can aid vital sign measuring for those interested in tracking their health. In this diagnostic accuracy study, we evaluated the performance of the VitalWellness device (VW), a wireless, compact, noninvasive device that measures four vital signs (VS) - blood pressure (BP), heart rate (HR), respiratory rate (RR), and body temperature (BT) - using the index finger and forehead.

Methods:
Adult volunteers with VS that fell both within and outside of the normal physiological range were enrolled to provide BP, HR, RR, and BT measurements using both the VW and Food and Drug Administration-approved reference devices. A subgroup of participants underwent an additional test to analyze the VW’s performance on HR and RR outside of normal physiological ranges. Statistical measurements were plotted on scatter and Bland-Altman plots. Sensitivity analyses to evaluate the VW’s performance by gender, skin color, finger size, and auxiliary activities were performed.

Results:
A total of 263 participants completed the study. On an average, systolic BP measured using the VW was 10 mmHg lower than that of the reference device (correlation coefficient r = 0.7), whereas diastolic BP was 3 mmHg lower (r = 0.6), and RR was 2 bpm lower (r = 0.7). VW HR and BT measurements were, on average, 1 bpm and 0.3°F higher than the corresponding reference measurements (r = 0.9 and r = 0.3), respectively.

Conclusion:
The VW device is well-suited for home-based, nonmedical monitoring of HR, RR, and BP. Further improvement in measurement accuracy is required to enable applications for medical use.
El aula invertida con alumnos de primero de magisterio: fortalezas y debilidades
Authors: García Hernández M.L. , Porto Currás M. , Hernández Valverde F.J. 
Published: December 2019

<p>Este artículo presenta los resultados de una experiencia de innovación realizada con alumnos de primer curso del Grado de Maestro de Educación Primaria. Partiendo de las tendencias globales a favor del fomento de capacidades de aprendizaje autónomo y colaborativo, un grupo de profesores miembros del Grupo de Innovación Docente EIE-GID, ha buscado una graduación progresiva en la dificultad y protagonismo a asumir por el alumnado en las tareas de aprendizaje. Se busca superar la dicotomía de clases teóricas y clases prácticas, empleando metodologías diversas, pero que comparten entre sus rasgos: fomentar la autonomía del alumno, procurar la motivación, adopción de riesgos y elaboración de respuestas alternativas, promoviendo responsabilidad, con opciones de experimentar y estimular el desarrollo de una actitud de superación permanente. Para ello, se plantean tareas que permiten hacer frente a acontecimientos imprevistos, tomar iniciativas, ser responsables y autónomos, movilizar recursos, comunicarse y relacionarse de manera efectiva y evaluar los efectos de las propias decisiones críticamente, de forma que los últimos temas se desarrollan basándose en la estrategia metodológica Aula Invertida. Al mismo tiempo, se diseña un protocolo de recogida de información y evaluación dirigido a los propios estudiantes para valorar el proceso y los resultados obtenidos. Las respuestas obtenidas muestran una valoración positiva sobre la experiencia, si bien los alumnos reclaman clases expositivas para aclarar las dudas sobre contenidos.</p>
Synthesis, structural elucidation and X-ray crystallographic studies of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)prop-2-en-1-one
Authors: Nongrum Stability , Das Susma , Khanikar Shikpika , Vishwakarma Jai Narain 
Published: December 2019

A new enaminone was synthesized by reacting 3,5-bis-(trifluoromethyl)acetophenones and N,N-dimethylformamide dimethyl acetal and its detailed structural and crystalline properties were studied. The crystal data were found to be as C13H11F6NO, monoclinic, space group P21/c (no. 14), a = 8.1556(8) Å, b = 24.877(3) Å, c = 7.6067(7) Å, β = 116.745(6)°, V = 1378.2(3) Å3, Z = 4, T = 293(2) K, μ(MoKα) = 0.150 mm-1, Dcalc = 1.500 g/cm3, 40777 reflections measured (5.594° ≤ 2Θ ≤ 56.786°), 3413 unique (Rint = 0.1040, Rsigma = 0.0584) which were used in all calculations. The final R1 was 0.0771 (I > 2σ(I)) and wR2 was 0.2541 (all data).
Indole alkaloids from Vinca erecta type of sarpagine and ajmaline
Authors: Adizov Shahobiddin , Tashkhodjaev Bakhodir 
Published: December 2019

The single crystal X-ray diffraction method established the absolute configuration of the Vinca erecta indole alkaloids of the akuammidine sarpagine type (3S, 5S, 15R, 16R) and its o-acyl derivative, as well as the type of ajmaline, quebrachidine (2S, 3S, 5S, 7R, 15S, 16R, 17S) and majoridine (2R, 3S, 5S, 7R, 15R, 16S, 17R). Crystal data for C21H24N2O3 (1): orthorhombic, space group P212121 (no. 19), a = 6.3949(5) Å, b = 13.5009(10) Å, c = 22.461(3) Å, Z = 4, 7694 reflections measured (7.64° ≤ 2Θ ≤ 152.294°), 3813 unique (Rint = 0.0798) which were used in all calculations. The final R1 was 0.0680 (I > 2σ(I)) and wR2 was 0.1650 (all data). Crystal data for C23H26N2O4 (2): orthorhombic, space group P212121 (no. 19), a = 9.9730(13) Å, b = 10.2090(10) Å, c = 20.409(3) Å, Z = 4, 7959 reflections measured (8.666° ≤ 2Θ ≤ 151.998°), 4212 unique (Rint = 0.0386) which were used in all calculations. The final R1 was 0.0477 (I > 2σ(I)) and wR2 was 0.1171 (all data). Crystal data for C42H48N4O6 (3): monoclinic, space group P21 (no. 4), a = 8.9320(10) Å, b = 21.515(5) Å, c = 9.5420(10) Å, β = 97.103(10)°, Z = 2, 16677 reflections measured (9.34° ≤ 2Θ ≤ 151.836°), 7393 unique (Rint = 0.0278) which were used in all calculations. The final R1 was 0.0366 (I > 2σ(I)) and wR2 was 0.1037 (all data). Crystal data for C23H28N2O3 (4): orthorhombic, space group P212121 (no. 19), a = 10.636(2) Å, b = 11.208(12) Å, c = 16.725(13) Å, Z = 4, 1650 reflections measured (9.498° ≤ 2Θ ≤ 119.97°), 1650 unique (Rint = 0.0436) which were used in all calculations. The final R1 was 0.0608 (I > 2σ(I)) and wR2 was 0.1720 (all data). In alkaloids such as sarpagine and ajmaline exo, the substituents of alkaloids do not lead to conformational changes of a stable polycyclic framework. In the series of sarpagine, alkaloids form mono-salts in the tetrahedral nitrogen N4, and in indolines of the ajmaline type, the tetrahedral hybridization of the N1 and N4 atoms favors the formation of disols. In V. erecta alkaloids, the exomethylene fragment (C18-C19=C20-C21) of the polycyclic backbone always takes on the E-state.
Brown’s Syndrome
Authors: Saluja Gunjan , Bhari Anju 
Published: December 2019

Brown’s syndrome, also known as superior oblique tendon sheath syndrome or Janesch Brown syndrome is characterized by limitation of elevation in adduction with divergence in up gaze, and a normal elevation in abduction. The term Brown’s plus is used when superior oblique overaction is present along with Brown’s syndrome.
The syndrome can be congenital or acquired, and a large number of causes have been attributed for the same. Various management options include complete tenectomy of superior oblique, superior oblique recession, tendon lengthening procedures and split tendon lengthening.
Advancing Student Solid Geometry Achievement through Constructivist-based Instructional Models
Authors: Charles-Ogan Gladys , Wonu Nduka 
Published: December 2019

This study investigated the applicability of a class of instructional models based on constructivism in improving the achievement of senior secondary students in solid geometry using the quasi-experimental design. Two constructivist-based instructional models used were Teaching for Understanding (TfU) and Metacognitive Instructional (MCI) models. The exploration area was the Emohua Local Government Area (LGA) of Rivers State, Nigeria. An aggregate of 86 Senior Secondary Class I (SSC1) students took an interest in the investigation. To evaluate the achievement of the students in solid geometry, the researchers structured, approved and utilised an achievement test in solid geometry which contained 50 multiple-choice questions. The reliability of the test was determined using KR-21 to get an index of 0.84. This research work was guided by two research questions and two null hypotheses separately. The mean, standard deviation, box-plots and Analysis of Covariance (ANCOVA) were used for data analysis. The findings showed that the class of instructional models based on constructivism significantly enhanced the learning of solid geometry amongst the SSC1 students. The MCI model was less effective than the TfU model in improving the learning of the students. Sex had no significant influence on the solid geometry achievement of SSC1 students irrespective of the instructional model used. The exploration suggested among others that solid geometry ought to be instructed by the educators of arithmetic using the instructional models based on constructivism.
Sacituzumab govitecan, an antibody‐drug conjugate targeting trophoblast cell‐surface antigen 2, shows cytotoxic activity against poorly differentiated endometrial adenocarcinomas in vitro and in vivo
Authors: Perrone Emanuele , Manara Paola , Lopez Salvatore , Bellone Stefania , Bonazzoli Elena , Manzano Aranzazu , Zammataro Luca , Bianchi Anna , Zeybek Burak , Buza Natalia , Tymon‐Rosario Joan , Altwerger Gary , Han Chanhee , Menderes Gulden , Huang Gloria S. , Ratner Elena , Silasi Dan‐Arin , Azodi Masoud , Hui Pei , Schwartz Peter E. , Scambia Giovanni , Santin Alessandro D. 
Published: December 2019

Endometrial cancer is the most common gynecologic malignancy in developed countries. The antibody–drug conjugate (ADC) sacituzumab govitecan (SG) targets trophoblast cell‐surface antigen‐2 (Trop‐2) – a cell‐surface glycoprotein highly expressed in many epithelial tumors – and delivers the active metabolite of irinotecan SN‐38 to Trop‐2‐positive tumor cells. We evaluated Trop‐2 expression in endometrial endometrioid carcinoma (EC) tissues and the activity of SG against primary poorly differentiated EC cell lines and xenografts. Trop‐2 expression was assessed in 143 formalin‐fixed–paraffin‐embedded tumors and seven primary tumor cell lines by immunohistochemistry and flow cytometry, respectively. Cell viability of primary tumor cell lines was assessed following exposure to SG, or control antibodies. Antibody‐dependent cell cytotoxicity (ADCC) against Trop‐2‐positive and Trop‐2‐negative EC cell lines was measured in vitro using 4‐h chromium release assays. A Trop‐2‐positive EC xenograft model was used to determine the in vivo activity of SG. Moderate‐to‐strong staining was detected in 84% (120/143) of EC samples, whereas 43% (3/7) of the primary EC cell lines tested overexpressed Trop‐2. EC cell lines overexpressing Trop‐2 were significantly more sensitive to SG compared to control ADC (P = 0.014 and P = 0.005). Both SG and the unconjugated parental antibody hRS7 mediated high ADCC against Trop‐2‐positive cell lines. Moreover, SG induced significant bystander killing of Trop‐2‐negative tumors cocultured with Trop‐2‐positive tumors. In the xenograft model, intravenous administration of SG twice weekly for three weeks was well tolerated and demonstrated impressive tumor growth inhibition against poorly differentiated, chemotherapy‐resistant EC xenografts (P = 0.011). In summary, SG is a novel ADC with remarkable preclinical activity against poorly differentiated EC cell lines overexpressing Trop‐2. These findings warrant future clinical trials.
N‐Heterocyclic Carbene Catalyzed [3+2] Cycloaddition of Enals with β,γ ‐Unsaturated α ‐Ketimino Esters for the Synthesis of Multisubstituted Cyclopentanone
Authors: Shi Xiao‐Qian , Dong Meng‐Die , Duan Xiao‐Yong , Cao Teng‐Liang , Qi Jing 
Published: December 2019

AbstractA convenient strategy of N‐heterocyclic carbene catalyzed [3+2] cycloaddition of enals with β,γ‐unsaturated α‐ketimino esters is developed. This effective protocol features mild reaction conditions and broad substrate scope, which enables the rapid assembly of various benzoxazinone derived cyclopentanone scaffolds in good to high yields with excellent diastereoselectivities.magnified image
Synthesis of Chiral Aza‐[n.2.1] Skeletons by Separable Epimers of Intramolecular [3+2] Cross Cycloaddition of Cyclopropane 1,1‐Diesters with Chiral Sulfinylimines
Authors: Xia Miao‐Miao , Li Feng‐Xing , Ma You‐Ping , Song Le‐Le , Hou Yan‐Ni , Shi Zi‐Fa , Cao Xiao‐Ping 
Published: December 2019

AbstractReported herein is the construction of chiral aza‐[n.2.1] skeletons by separable epimers of intramolecular [3+2] cross cycloaddition of cyclopropane 1,1‐diesters with chiral sulfinylimines. The epimer products can be separated by silica gel column chromatography.magnified image