bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Optical Signal-based Intraocular Pressure-sensing Principle Using Pressure-sensitive Mechanoluminescent ZnS:Cu/PDMS Soft Composite
Authors: Kim Yooil , Roy Sunanda , Jung Gwang-Yong , Oh Jung-Sik , Kim Gi-Woo 
Published: October 2019

AbstractThis paper presents a novel principle for intraocular pressure (IOP)-sensing (monitoring) based on a pressure-sensitive soft composite in which a dual optical signal is produced in response to impulsive pressure input. For the initial assessment of the new IOP sensing principle, a human eye is modeled as the spherically shaped shell structure filled with the pressurized fluid, including cornea, sclera, lens and zonular fiber, and a fluid–structure interaction (FSI) analysis was performed to determine the correlation between the internal pressure and deformation (i.e., strain) rate of the spherical shell structure filled with fluid by formulating the finite element model. The FSI analysis results for human eye model are experimentally validated using a proof-of-conceptual experimental model consisting of a pressurized spherical shell structure filled with fluid and a simple air-puff actuation system. In this study, a mechanoluminescent ZnS:Cu- polydimethylsiloxane (PDMS)-based soft composite is fabricated and used to generate the dual optical signal because mechanically driven ZnS:Cu/PDMS soft composite can emit strong luminescence, suitable for soft sensor applications. Similar to the corneal behavior of the human eye, inward and outward deformations occur on the soft composite attached to the spherical shell structure in response to air puffing, resulting in a dual optical signal in the mechnoluminescence (ML) soft composite.
The impact of RHDV-K5 on rabbit populations in Australia: an evaluation of citizen science surveys to monitor rabbit abundance
Authors: Cox Tarnya E. , Ramsey David S. L. , Sawyers Emma , Campbell Susan , Matthews John , Elsworth Peter 
Published: October 2019

AbstractThe increasing popularity of citizen science in ecological research has created opportunities for data collection from large teams of observers that are widely dispersed. We established a citizen science program to complement the release of a new variant of the rabbit biological control agent, rabbit haemorrhagic disease virus (RHDV), known colloquially as K5, across Australia. We evaluated the impact of K5 on the national rabbit population and compared citizen science and professionally-collected spotlight count data. Of the citizen science sites (n = 219), 93% indicated a decrease in rabbit abundance following the release of K5. The overall finite monthly growth rate in rabbit abundance was estimated as 0.66 (95%CI, 0.26, 1.03), averaging a monthly reduction of 34% at the citizen science sites one month after the release. No such declines were observed at the professionally monitored sites (n = 22). The citizen science data submissions may have been unconsciously biased or the number of professional sites may have been insufficient to detect a change. Citizen science participation also declined by 56% over the post-release period. Future programs should ensure the use of blinded trials to check for unconscious bias and consider how incentives and/or the good will of the participants can be maintained throughout the program.
Promoting Counseling Skills in Audiology Clinical Supervisors: Considerations for Professional Development
Authors: Muñoz Karen , Ong Clarissa W. , Whicker John , Twohig Michael 
Published: October 2019

Purpose
Clinical supervision for counseling skill development can be variable and can undermine student ability to learn patient-centered care communication. The current study aimed to evaluate the effectiveness of consultation and feedback sessions on counseling behavior, in actual clinical practice, among clinical audiology supervisors. We also collected qualitative data on participants' experiences and suggestions for improving the counseling intervention to increase counseling communication in audiology graduate training programs.

Method
We used a noncurrent multiple baseline design and staggered the counseling intervention to control for effects of concurrent events and passage of time.

Results
Two participants showed small but reliable increases in counseling behavior, whereas the 3rd participant showed bigger but less stable increases in counseling. Participants reported that brief feedback sessions were helpful; however, they also mentioned barriers to counseling, such as worries with how much time counseling could take when they have back-to-back appointments.

Conclusion
Clinical audiology supervisors were able to improve their counseling skills in real-life sessions with regular feedback. More structure may be needed to strengthen future counseling skills.
New deep coronal spectra from the 2017 total solar eclipse
Authors: Koutchmy S. , Baudin F. , Abdi Sh. , Golub L. , Sèvre F. 
Published: October 2019

Context. The origin of the high temperature of the solar corona, in both the inner bright parts and the more outer parts showing flows toward the solar wind, is not understood well yet. Total eclipses permit a deep analysis of both the inner and the outer parts of the corona using the continuum white-light (W-L) radiations from electrons (K-corona), the superposed spectrum of forbidden emission lines from ions (E-corona), and the dust component with F-lines (F-corona).
Aims. By sufficiently dispersing the W-L spectrum, the Fraunhofer (F) spectrum of the dust component of the corona appears and the continuum Thomson radiation can be evaluated. The superposed emission lines of ions with different degrees of ionization are studied to allow the measurement of temperatures, non-thermal velocities, Doppler shifts, and abundances to constrain the proposed heating mechanisms and understand the origin of flows that lead to solar wind.
Methods. We describe a slit spectroscopic experiment of high spectral resolution to provide an analysis of the most typical parts of the quasi-minimum type corona observed during the total solar eclipse of Aug. 21, 2017 from Idaho, USA. Streamers, active region enhancements, and polar coronal holes (CHs) are measured well using deep spectra.
Results. Sixty spectra are obtained during the totality with a long slit, covering ±3 solar radii in the range of 510 nm to 590 nm. The K+F continuum corona is exposed well up to two solar radii. The F-corona can be measured even at the solar limb. New weak emission lines were discovered or confirmed. The rarely observed Ar X line is detected almost everywhere; the Fe XIV and Ni XIII lines are clearly detected everywhere. For the first time hot lines are also measured inside the CH regions. The radial variations of the non-thermal turbulent velocities of the lines do not show a great departure from the average values. No significantly large Doppler shifts are seen anywhere in the inner or the middle corona. The wings of the Fe XIV line show some non-Gaussianity.
Conclusions. Deep slit coronal spectra offered an opportunity for diagnosing several aspects of coronal physics during a well observed total eclipse without extended investments. The analysis of the ionic emission line profiles offers several powerful diagnostics of the coronal dynamics; the precise measurement of the F-continuum component provides insight into the ubiquitous dust corona at the solar limb.
Notalgia paraesthetica – Ein Review mit Fallbeispiel
Authors: Moll I. 
Published: October 2019

ZusammenfassungNotalgia paraesthetica ist eine relativ häufige periphere sensorische Neuropathie, die mit Juckreiz, Schmerzen, Hyper- oder Hypästhesie einhergeht. Sie tritt lokalisiert unilateral am medio-caudalen Schulterblatt auf und hält meist Jahre an. Die Haut kann rötlich-bräunlich, lichenifiziert erscheinen oder ohne Effloreszenzen.Als Ursachen werden Irritationen der R. dorsales der Spinalnerven Th2 – Th6 durch Traumen, Degeneration u. ä. postuliert, die bildgebend abzuklären sind. Auch erhöhte Neuropeptide werden diskutiert. Die Therapie ist schwierig und langwierig. An erster Stelle stehen die Therapie der orthopädischen Veränderungen und lokale Therapien mit den üblichen antipruriginösen Substanzen. Auch Calcineurin-Inhibitoren, Capsaicin und Cannabinoid-Rezeptor-Agonisten wirken, jedoch ist mit Rezidiven zu rechnen. Systemische Therapien umfassen verschiedene zentral schmerzmodulierende und antidepressive Medikamente, daneben Botox, UVB oder auch elektrische Stimulationen.
Postoperative Ernährung und Rehabilitation
Authors: Reith Hans Bernd 
Published: October 2019

ZusammenfassungDie Beschäftigung mit Ernährung hat in den letzten Jahren einen neuen Stellenwert in der klinischen Medizin erhalten. Durch Konzepte der Fast-track-Chirurgie und des ERAS wird mehr auf einen adäquaten Ernährungszustand geachtet.Die postoperative Ernährung benötigt im klinischen Alltag ein standardisiertes Konzept, wie in einzelnen Phasen oder bei verschiedenen Zuständen vorgegangen werden kann und muss. Dabei ist es wichtig, dass man Patienten schon mit einer Prehabilitation an die Rehabilitation heranführt.Eine Hyper- als auch eine Hypoalimentation sollte unbedingt vermieden werden, ein langsamer Kostaufbau ist mehr als sinnvoll. Dabei darf nicht vergessen werden, dass bei Patienten mit einer Mangelernährung und bei denen, die innerhalb von 5 – 7 Tagen keine adäquate orale/enterale Kost zu sich nehmen können, frühzeitig mit einer parenteralen Ernährung begonnen werden muss.Die Intensität des Überwachungs- und Unterstützungsaufwands um zu einer korrekten Kalorienaufnahme zu gelangen, ist dabei enorm und bindet personelle Ressourcen. Da aber die Qualitätsverbesserung oberstes Gebot wird, sollte sich gerade für das Problem adäquate Ernährung eine breite Basis finden lassen. Die notwendigen Vorarbeiten sind vorhanden.
Comparison of Approaches to Select a Propensity Score Matched Control Group in the Absence of an Obvious Start of Follow Up for this Group: An Example Study on the Economic Impact of the DMP Bronchial Asthma
Authors: Jacob Josephine , Schmedt Niklas , Hickstein Lennart , Galetzka Wolfgang , Walker Jochen , Enders Dirk 
Published: October 2019

Abstract
Background Claims data are a valuable data source to investigate the economic impact of new health care services. While the date of enrollment into the new service is an obvious start of follow-up for participants, the strategy to select potential controls is not straightforward due to a missing start of follow-up to ascertain possible confounders. The aim of this study was to compare different approaches to select controls via Propensity Score Matching (PSM) using the disease management program (DMP) bronchial asthma (BA) as an example.
Methods We conducted a retrospective cohort study of BA patients between 2013 and 2016 to examine total one-year health care costs and all-cause mortality. We implemented different scenarios regarding the selection of potential controls: I) allotment of a random index date with subsequent PSM, II) calendar year-based PSM (landmark analysis) and III) calendar quarter-based PSM. In scenario I, we applied 2 approaches to assign a random index date: a) assign random index date among all quarters with a BA diagnosis and b) assign random index date and thereafter examine if a BA diagnosis was documented in that quarter.
Results No significant differences in total one-year health care costs between DMP BA participants and non-participants were observed in any of the scenarios. This could to some extent be explained by the higher mortality in the control groups in all scenarios.
Conclusion If the loss of potential controls can be compensated, scenario Ib is a pragmatic option to select a control group. If that is not the case, scenario III is the more sophisticated approach, with the limitation that baseline characteristics prior PSM cannot be depicted and computational time or memory size needed to conduct the analysis need to be sufficient.
Endoscopic mucosal resection with anchoring of the snare tip: multicenter retrospective evaluation of effectiveness and safety
Authors: Pioche Mathieu , Wallenhorst Timothée , Lepetit Hugo , Lépilliez Vincent , Rivory Jérôme , Legros Romain , Rostain Florian , Bianchi Laurent , Charissoux Aurélie , Hervieu Valérie , Moreno-Garcia Maira , Robinson Philip , Saurin Jean-Christophe , Ponchon Thierry , Viprey Marie , Roche Laurent , Subtil Fabien , Jacques Jérémie 
Published: October 2019

Abstract
Background Endoscopic mucosal resection (EMR) with snare is the recommended technique to resect non-invasive colorectal neoplastic lesions between 10 and 30 mm in diameter. The objective of EMR is to resect completely the neoplastic tissue en bloc and preferably with free margins (R0), avoiding recurrences. Anchoring the tip of the snare in the submucosa is a technical trick that allows snare sliding to be reduced and larger pieces to be caught. The aim of the present study was to evaluate the effectiveness and safety of anchoring-EMR (A-EMR).
Methods This was a retrospective analysis of A-EMR procedures for lesions of diameter between 10 and 30 mm (endoscopic evaluation) performed consecutively in four French centers between May 2017 and January 2018. A-EMR was routinely performed for all EMR using Olympus conventional snares (10 or 25 mm). The primary outcome was evaluation of the proportion of R0 resections.
Results A total of 141 A-EMR procedures were performed by 10 operators. Mean lesion size was 19.8 mm. Anchoring was feasible in 96.5 % of cases. There were 81.6 % en bloc resections and 70.2 % R0 resections, with the percentage of procedures decreasing with increasing lesion size (82.8 % < 20 mm, 55.3 % 21 – 30 mm, and 50.0 % > 30 mm, P = 0.002). Complete perforations closed endoscopically occurred in 3/141 cases (2.1 %); none occurred in lesions < 20 mm in size (0 /87).
Conclusion The A-EMR technique appears to be promising with a high proportion of R0 for lesions of 10 – 20 mm in size without any perforations. It could also offer an alternative to endoscopic submucosal dissection (ESD), or to hybrid techniques to reach R0 for lesions between 20 and 30 mm in size.
High Dose Chemotherapy with Autologous Stem Cell Transplantation in Hepatoblastoma does not Improve Outcome. Results of the GPOH Study HB99
Authors: Häberle Beate , Maxwell Rebecca , Schweinitz Dietrich von , Schmid Irene 
Published: October 2019

Abstract
Introduction The purpose of the German HB99 trial (1999–2008) for hepatoblastoma (HB), was primarily to analyse the effect of high dose (HD) chemotherapy with carboplatin/etoposide (CE) in high risk (HR) patients with extended tumors, vessel involvement, extrahepatic tumor or distant metastases. In standard risk (SR) patients the effect of treatment reduction was analysed.
Methods HR patients received 2 cycles CE at conventional dose, followed by 2 at HD with subsequent autologous stem cell transplantation before delayed surgery. SR patients received 3–4 cycles of ifosfamide, cisplatin and doxorubicin (IPA) and delayed surgery. Analysis was on an intention to treat basis including resection rate, AFP decline, event free survival (EFS) and overall survival (OS). The patients with HD therapy were additionally analysed on an “as treated” basis. The results were compared to historical/published data.
Results Of the 142 patients, the 5-y OS was 58% for the 57 HR patients and 94% for the 85 SR patients. The AFP decline after 2 cycles CE was ≥ 50% in > 90% of the patients. 12/18 (67%) patients treated with HD therapy showed an AFP decline after the first cycle (as treated). Tumor resection was possible in 89% of the patients. The median FU was 7.4 years. Late deaths occurred in 4 patients.
Conclusion Use of HD chemotherapy for HB did not improve patient outcomes, compared to contemporaneous and more recent trials (SIOPEL 4 trial). Reduction of therapy in SR patients was possible without worsening of results compared to previous trials. The tumor response to CE was good. CE can therefore be considered for relapse patients.
A Comparison of One- and Four-Open-Chart Access: No Change in Computerized Provider Order Entry Error Rates
Authors: Scariati Paula , Knapp Herschel , Gray Stuart 
Published: October 2019

Abstract
Objective To assess changes in computerized provider order entry error rates among providers who with less than 24-hour notice were switched from four-chart access to one-chart-only access.
Methods An interrupted time series analysis of emergency medicine providers, hospitalists, and maternal child health providers was performed with pairwise comparison of computerized provider order entry error rates within and between specialties. This retrospective snapshot consisted of four phases. Phase 1 was the baseline 2 weeks where providers were privileged to work with up to four charts open. Phase 2 was the 2-week period where providers were limited to one-chart access. Phase 3 was the 2-week period where providers were returned to four-chart access. And phase 4 was a 2-week period 3 months following the end of phase 3.
Results Analysis of the overall and specialty-stratified cohorts revealed no statistically significant differences in median computerized provider order entry error rates across the four phases (Wilcoxon signed-rank test, α = 0.05). However, statistically significant differences in median computerized provider order entry error rates were detected between the three specialties within each phase of the study (Kruskal–Wallis, p < 0.001).
Conclusion Allowing providers in select specialties to have access to four charts simultaneously does not increase their computerized provider order entry error rates. Significant differences in error rates between specialties suggest the need for further study of the use of standardized order sets, charting, and workflow variations.
Role of Minimal Invasive Spine Surgery Techniques in Thoracolumbar Burst Fractures
Authors: Garg Kanwaljeet , Agrawal Deepak 
Published: October 2019

AbstractThoracolumbar burst fractures are one of the most common traumatic fractures seen. Management options vary from nonoperative to operative. Among the operative approaches, minimal invasive approaches are gaining popularity. However, all the cases are not suitable for minimal invasive approaches. We discuss the various minimal invasive approaches and their role in the management of thoracolumbar burst fractures.
Motivations for Using Electronic Cigarettes in Young Adults: A Systematic Review
Authors: Kinouani Shérazade , Leflot Chloé , Vanderkam Paul , Auriacombe Marc , Langlois Emmanuel , Tzourio Christophe 
Published: October 2019

Background: The most common reasons why adults use e-cigarettes are to stop or reduce tobacco smoking. However, it is unclear if this reason is evenly distributed between young and older adults. Objectives: describe the motivations for e-cigarette use amongst young adults aged 18–25 and compare the reasons for using e-cigarettes of people who currently or formerly used tobacco products to those who had never smoked tobacco prior e-cigarette use. Methods: PubMed®, Scopus®, Cochrane Library®, SocINDEX®, PsycARTICLES®, Psychology and Behavioral Sciences Collection® and PsycINFO® databases were used. English written articles were screened up to March 2018. Depending on study design, quality was assessed using The STROBE or RATS checklists. Results: Six articles were included in the review, all with a moderate quality of evidence. Independently of smoking status, curiosity was the most frequently reported reason for initiating the use of e-cigarettes in young adults. Reasons for continuing to use e-cigarettes were various. The continued use of e-cigarettes could be either a means to replicate smoking habits, or a way for a different and personalized use of nicotine by inhalation. Conclusions: Reasons for using e-cigarettes in young adults are varied and are not limited to stopping smoking.
Home Induction and Outpatient Treatment of Kratom use Disorder with Buprenorphine-Naloxone: A Case Report in a Young Adult
Authors: Schmuhl Kelsey K. , Gardner Spencer M. , Cottrill Casey B. , Bonny Andrea E. 
Published: October 2019

Background: The use of the natural product, kratom, has increased significantly in recent years. The active compounds in kratom have been shown to produce both opioid and stimulant-like effects. While kratom is marketed as a safe, non-addictive method to treat pain and opioid withdrawal, there have been reports demonstrating that kratom is physiologically addictive and linked to overdose deaths. A limited number of case-reports are available describing treatment of kratom use disorder in middle-aged adults, generally in the context of chronic pain and in inpatient settings. Our case is unique in that we describe outpatient treatment of kratom use disorder in a young adult with comorbid attention deficit hyperactivity disorder (ADHD) and in the absence of chronic pain. Case: A 20-year-old college student with ADHD presented to an office-based opioid agonist treatment clinic (OBOT) for treatment of kratom use disorder. He was unable to attend inpatient or residential substance use treatment due to work and school obligations. Additionally, he had stopped taking his prescribed stimulant due to cardiac side effects. The OBOT team successfully initiated buprenorphine-naloxone (BUP/NAL) sublingual films via home induction to treat his kratom use disorder. The patient is being monitored monthly with plans to slowly taper his BUP/NAL dose as tolerated. Discussion: We present a case of a young adult male with kratom use disorder, complicated by a diagnosis of ADHD, successfully treated with BUP/NAL via home induction. The patient is currently kratom-free, reports improved mood and sleep patterns since initiating BUP/NAL, and is able to once again tolerate his ADHD stimulant medication. Healthcare providers should be aware of the use of kratom and consider utilizing BUP/NAL to treat dependence to this botanical drug.
Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβ pathway in in-vitro and in-vivo models
Authors: Ma Ding , He Jinlong , He Dapeng 
Published: October 2019

ABSTRACT
This study was conducted to evaluate the protective effects of chamazulene against IL-1β-induced rat primary chondrocytes and complete Freund’s adjuvant (CFA)-induced osteoarthritic inflammation in rats. Oxidative stress markers, pro-inflammatory cytokines, and regulatory proteins were measured. Chamazulene significantly reverted (p &lt; 0.05) the levels of lipid peroxidation and enhanced the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) enzymes against IL-1β and CFA-induced oxidative stress. The levels of TNF-α and IL-6 were reduced (p &lt; 0.05) in chamazulene treatment against IL-1β and CFA-induced inflammation. Western blot analysis results on the expressions of MMP-3, MMP-9, p65 NF-kβ, iNOS, and COX-2 showed chamazulene was able to protect the chondrocytes against IL-1β-induced osteoarthritic inflammation. Histopathology of rat hind ankle showed chamazulene significantly protected against CFA-induced osteoarthritic inflammation. Therefore, chamazulene can be recommended as a therapeutic agent for clinical trials against osteoarthritic inflammation.
Preface to X IAQVEC 2019: nearly Zero Energy Buildings
Authors: Berardi Umberto , Allard Francis 
Published: October 2019

Dear Colleagues,
on behalf of the Organizers, it is our great pleasure and an honor to welcome you to the X IAQVEC 2019: nearly Zero Energy Buildings, which will be held on September 5 to 7 in Bari, Italy.
The Conference was hosted by the Politecnico di Bari and co-organized by three universities, the Ryerson University (Ontario, Canada), the Politecnico di Bari (Italy), the Universita del Sannio (Italy).
X IAQVE 2019 focused on the theme “Healthy nearly Zero Energy Buildings” and envisaged the participation of over 450 scientists, researchers and practitioners and the submission of over 300 papers covering a broad range of topics relevant to the main subjects of Building Science.
List of Scientific Committee X IAQVEC 2019 are avaliable in this pdf.