bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of movement representation techniques on motor learning of thumb-opposition tasks
Authors: Cuenca-Martínez Ferran , Suso-Martí Luis , León-Hernández Jose Vicente , La Touche Roy 
Published: July 2020

AbstractThe present work is the first study that assess long run change after motor learning. The study’s main objective was to evaluate the short to medium-term impact of motor imagery (MI) and action observation (AO) on motor learning of a sequence of thumb-opposition tasks of increasing complexity. We randomly assigned 45 participants to an AO, MI, or placebo observation (PO) group. A sequence of 12 thumb-opposition tasks was taught for 3 consecutive days (4 per day). The primary outcome was accuracy. The secondary outcomes were required time and perfect positioning. The outcomes were assessed immediately after the intervention and at 1 week, 1 month and 4 months postintervention. Regarding the primary outcome, AO group had significantly higher accuracy than the MI or PO group until at least 4 months (p < 0.01, d > 0.80). However, in the bimanual positions, AO was not superior to MI at 1 week postintervention. Regarding secondary outcomes, AO group required less time than the MI group to remember and perform the left-hand and both-hand gestures, with a large effect size (p < 0.01, d > 0.80). In terms of percentage of perfect positions, AO group achieved significantly better results than the MI group until at least 4 months after the intervention in the unimanual gestures (p < 0.01, d > 0.80) and up to 1 month postintervention in the bimanual gestures (p = 0.012, d = 1.29). AO training resulted in greater and longer term motor learning than MI and placebo intervention. If the goal is to learn some motor skills for whatever reason (e.g., following surgery or immobilization.), AO training should be considered clinically.
Application of remote sensing to identify Copper–Lead–Zinc deposits in the Heiqia area of the West Kunlun Mountains, Chinas
Authors: Fan Yu-Hai , Wang Hui 
Published: July 2020

AbstractThe harsh natural environment and inaccessibility of the West Kunlun Mountains are barriers for their investigation via field geology. Remote sensing technology has the advantage of being efficient on a macroscale and not being restricted by terrain or road conditions in sparsely vegetated areas with exposed bedrock. This work focuses on copper–lead–zinc deposits in the Heiqia area in the West Kunlun Mountains as a case study to illustrate the application of IKONOS remote sensing images as major data sources to fabricate a standard image map, the extraction of information on ore-controlling factors and mineralization through the use of image enhancement methods, and the interpretation of remote sensing data to identify mineral resources. Alteration anomaly information was extracted from ASTER data, verified via field survey and sampling, and used to develop a remote sensing model for utilization in future prospecting efforts. The results of the survey showed that in IKONOS (band 3, 2, and 1 synthesis) images, the copper mineralization zone exhibits interlaced gray-white, blue-gray, and blue tones in a narrow strip-like pattern, while the lead–zinc mineralization zone shows gray-white, light gray-yellow, and yellowish-brown tones in a strip-like pattern. The main remotely sensed alteration anomalies are characteristic of hydroxyl. Six hydroxyl anomalies were delineated in the study area, of which five were found to be copper–lead–zinc deposits. The location of the ore bodies coincides well with the ASTER anomalies extracted. Two Cu–Pb–Zn mineralization belts are present in the study area. The ore-bearing rock series of belt No. I is phyllite interbedded with metasandstone, and the ore comprises mainly copper deposits supplemented by lead–zinc deposits. Belt No. II is in limestone and consists mainly of lead–zinc deposits supplemented by copper deposits. A remote sensing geological prospecting model for structurally altered Wenquangou Group copper–lead–zinc deposits with a genesis related to hot water basins is established. This provides a basis for future prospecting for similar minerals in the West Kunlun metallogenic belt.
Impact of 10-Myr scale monsoon dynamics on Mesozoic climate and ecosystems
Authors: Ikeda Masayuki , Ozaki Kazumi , Legrand Julien 
Published: July 2020

AbstractEarth’s orbital variations on timescales of 104–105 years, known as Milankovitch cycles, have played a critical role in pacing climate change and ecosystem dynamics, through glacial and/or monsoon dynamics. However, the climatic and biotic consequences of these cycles on much longer (~ 107 years) timescales remain unclear, due to a lack of long proxy records with precise age constraints. Here, we show ~ 10-Myr scale variations in early Mesozoic (250–180 Ma) records of lake-level, desert distribution, biogenic-silica burial flux, atmospheric CO2 levels (pCO2), and sea-surface-temperature (SST). Their phase relationships, coupled with carbon cycle modeling results, suggest that orbitally-paced summer monsoon dynamics modulates changes in terrestrial weatherability by ~ 20%, affecting changes in pCO2 of up to 500–1,000 ppmv and 3–7 °C SST. We also infer that these ~ 10-Myr scale climatic variations could have been causally linked to biotic turnover, size variations in dinosaur footprints, and tetrapod dispersal, potentially through spatio-temporal variations in resource availability and arid-hot climatic barriers at low-middle latitudes.
Discovery of a new mode of oviparous reproduction in sharks and its evolutionary implications
Authors: Nakaya Kazuhiro , White William T. , Ho Hsuan-Ching 
Published: July 2020

AbstractTwo modes of oviparity are known in cartilaginous fishes, (1) single oviparity where one egg case is retained in an oviduct for a short period and then deposited, quickly followed by another egg case, and (2) multiple oviparity where multiple egg cases are retained in an oviduct for a substantial period and deposited later when the embryo has developed to a large size in each case. Sarawak swellsharkCephaloscyllium sarawakensisof the family Scyliorhinidae from the South China Sea performs a new mode of oviparity, which is named “sustained single oviparity”, characterized by a lengthy retention of a single egg case in an oviduct until the embryo attains a sizable length. The resulting fecundity of the Sarawak swellshark within a season is quite low, but this disadvantage is balanced by smaller body, larger neonates and quicker maturation. The Sarawak swellshark is further uniquely characterized by having glassy transparent egg cases, and this is correlated with a vivid polka-dot pattern of the embryos. Five modes of lecithotrophic (yolk-dependent) reproduction, i.e. short single oviparity, sustained single oviparity, multiple oviparity, yolk-sac viviparity of single pregnancy and yolk-sac viviparity of multiple pregnancy were discussed from an evolutionary point of view.
Surface Water CO2 variability in the Gulf of Mexico (1996–2017)
Authors: Kealoha Andrea K. , Shamberger Kathryn E. F. , DiMarco Steven F. , Thyng Kristen M. , Hetland Robert D. , Manzello Derek P. , Slowey Niall C. , Enochs Ian C. 
Published: July 2020

AbstractApproximately 380,000 underway measurements of sea surface salinity, temperature, and carbon dioxide (CO2) in the Gulf of Mexico (GoM) were compiled from the Surface Ocean CO2 Atlas (SOCAT) to provide a comprehensive observational analysis of spatiotemporal CO2 dynamics from 1996 to 2017. An empirical orthogonal function (EOF) was used to derive the main drivers of spatial and temporal variability in the dataset. In open and coastal waters, drivers were identified as a biological component linked to riverine water, and temperature seasonality. Air-sea flux estimates indicate the GoM open (− 0.06 ± 0.45 mol C m−2 year−1) and coastal (− 0.03 ± 1.83 mol C m−2 year−1) ocean are approximately neutral in terms of an annual source or sink for atmospheric CO2. Surface water pCO2 in the northwest and southeast GoM open ocean is increasing (1.63 ± 0.63 µatm year−1 and 1.70 ± 0.14 µatm year−1, respectively) at rates comparable to those measured at long-term ocean time-series stations. The average annual increase in coastal CO2 was 3.20 ± 1.47 µatm year-1 for the northwestern GoM and 2.35 ± 0.82 µatm year−1 for the west Florida Shelf. However, surface CO2 in the central (coastal and open) GoM, which is influenced by Mississippi and Atchafalaya River outflow, remained fairly stable over this time period.
EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression
Authors: Malik Ankita , Pal Rahul , Gupta Satish Kumar 
Published: July 2020

AbstractThe members of human miR-17-92 cluster are implicated in several cancers and are known to increase cancer cells invasiveness. The present study reports reduced expression of miR-92a-1-5p in EGF treated HTR-8/SVneo trophoblastic cells by NGS and qRT-PCR. Overexpression of miR-92a-1-5p led to significantly reduced EGF-mediated HTR-8/SVneo cells invasion. MAPK8 and FAS were predicted to be miR-92a-1-5p targets, and confirmed to be reduced by qRT-PCR and Western blotting in trophoblast cells overexpressing miR-92a-1-5p. The binding of miR-92a-1-5p to MAPK8 and FAS 3′-UTR was confirmed by Luciferase reporter assay and Rescue assay. EGF increases MMP-2 & MMP-9 expression and reduces TIMP1 expression in HTR-8/SVneo cells. Inhibition of MAPK8 (by SP600125) reduced EGF-mediated MMP-9/TIMP1 ratio and invasion. Similarly, silencing of FAS by siRNA reduced EGF-mediated MMP-2/TIMP1 ratio and invasion. Treatment of HTR-8/SVneo cells with STAT1/3 inhibitors or siRNAs led to loss of EGF-mediated reduction in miR-92a-1-5p levels. Inserting the predicted binding sites of STAT3 present in promoter region of miR-92a-1-5p upstream of Luciferase promoter reduced its expression in presence of STAT3 expression vector. Thus, EGF leads to reduced miR-92a-1-5p expression which may be regulated by STAT1/STAT3 and controls HTR-8/SVneo cells invasion by targeting MAPK8 and FAS, which in turn increases MMP-2/MMP-9 expression.
The coffee agroecosystem: bio-economic analysis of coffee berry borer control (Hypothenemus hampei)
Authors: Cure José Ricardo , Rodríguez Daniel , Gutierrez Andrew Paul , Ponti Luigi 
Published: July 2020

AbstractCoffee, after petroleum, is the most valuable commodity globally in terms of total value (harvest to coffee cup). Here, our bioeconomic analysis considers the multitude of factors that influence coffee production. The system model used in the analysis incorporates realistic field models based on considerable new field data and models for coffee plant growth and development, the coffee/coffee berry borer (CBB) dynamics in response to coffee berry production and the role of the CBB parasitoids and their interactions in control of CBB. Cultural control of CBB by harvesting, cleanup of abscised fruits, and chemical sprays previously considered are reexamined here to include biopesticides for control of CBB such as entomopathogenic fungi (Beauveria bassiana, Metarhizium anisopliae) and entomopathogenic nematodes (Steinernema sp., Heterorhabditis). The bioeconomic analysis estimates the potential of each control tactic singly and in combination for control of CBB. The analysis explains why frequent intensive harvesting of coffee is by far the most effective and economically viable control practice for reducing CBB infestations in Colombia and Brazil.
Electrically programmable probabilistic bit anti-correlator on a nanomagnetic platform
Authors: McCray Mason T. , Abeed Md Ahsanul , Bandyopadhyay Supriyo 
Published: July 2020

AbstractExecution of probabilistic computing algorithms require electrically programmable stochasticity to encode arbitrary probability functions and controlled stochastic interaction or correlation between probabilistic (p-) bits. The latter is implemented with complex electronic components leaving a large footprint on a chip and dissipating excessive amount of energy. Here, we show an elegant implementation with just two dipole-coupled magneto-tunneling junctions (MTJ), with magnetostrictive soft layers, fabricated on a piezoelectric film. The resistance states of the two MTJs (high or low) encode the p-bit values (1 or 0) in the two streams. The first MTJ is driven to a resistance state with desired probability via a current or voltage that generates spin transfer torque, while the second MTJ’s resistance state is determined by dipole coupling with the first, thus correlating the second p-bit stream with the first. The effect of dipole coupling can be varied by generating local strain in the soft layer of the second MTJ with a local voltage (~ 0.2 V) and that varies the degree of anti-correlation between the resistance states of the two MTJs and hence between the two streams (from 0 to 100%). This paradigm generates the anti-correlation with “wireless” dipole coupling that consumes no footprint on a chip and dissipates no energy, and it controls the degree of anti-correlation with electrically generated strain that consumes minimal footprint and is extremely frugal in its use of energy. It can be extended to arbitrary number of bit streams. This realizes an “all-magnetic” platform for generating correlations or anti-correlations for probabilistic computing. It also implements a simple 2-node Bayesian network.
High frequency response of thick REBCO coated conductors in the framework of the FCC study
Authors: Romanov Artur , Krkotić Patrick , Telles Guilherme , O’Callaghan Joan , Pont Montse , Perez Francis , Granados Xavier , Calatroni Sergio , Puig Teresa , Gutierrez Joffre 
Published: July 2020

AbstractA thorough microwave response study of high temperature superconductors, considered as an alternative beam screen coating, has become integral in the design decisions for CERN’s future research infrastructure. Here, we present the surface resistance $$R_{s}$$Rs of various $$\text {REBa}_{2}\text {Cu}_{3}\text {O}_{7-x}$$REBa2Cu3O7-x (RE = rare earth) coated conductors available in large scale as a function of magnetic field in a broad temperature range measured by a Hakki–Coleman type resonator with resonant frequency $$\nu \approx {8}\,{\text {GHz}}$$ν≈8GHz. Analysis of the high frequency dissipation supported by DC transport characterization reveals the vortex dynamics in thick $$\text {REBa}_{2}\text {Cu}_{3}\text {O}_{7-x}$$REBa2Cu3O7-x films. Determined microscopic vortex parameters span over a wide range of magnitudes and reflect the relevance of the superconducting layer’s microstructure. We demonstrate that the depinning frequencies $$\nu _0$$ν0 surpass $$\nu$$ν, which confirms the operation in high performing, low dissipation pinning regime at measurement conditions. Surface impedance extrapolation to FCC-hh conditions points towards a significant outperformance of copper by coated conductors in terms of surface resistance. The surface resistance margins would open up potential ways for a more efficient frontier circular collider.
High taurine supplementation in plant protein-based diets improves growth and organoleptic characteristics of European seabass (Dicentrarchus labrax)
Authors: Kotzamanis Yannis , Tsironi Theofania , Brezas Andreas , Grigorakis Kriton , Ilia Vassiliki , Vatsos Ioannis , Romano Nicholas , van Eys Jan , Kumar Vikas 
Published: July 2020

AbstractPlant-based proteins are increasingly being used in aquafeeds, but one of the limitations is taurine deficiency that can be especially detrimental for carnivorous fish. In this study, taurine supplementation in high plant protein diets (low fish meal, 15%) was investigated on the growth performance and fillet organoleptic characteristics of European seabass (Dicentrarchus labrax), juveniles (78 ± 0.4 g). Five diets were formulated to contain 0 (C−), 5 (T5), 10 (T10) or 20 (T20) added taurine (g/kg), while a control diet (C+) included two-fold higher amount of fishmeal (30%) with no taurine supplementation. Seabass fed the T20 or C+ diet showed similar growth, which was significantly higher compared to those in the C-treatment. Histological examination of the muscle, liver and intestine were similar among treatments. No effect on spoilage bacterial growth or production of total volatile basic nitrogen was observed. Taurine supplementation significantly reduced fillet drip loss, while the fillets of European seabass fed the T10 and T20 diets showed significant higher and lower hardness and adhesiveness values, respectively. Moreover, fillet chewiness was also found to be significantly higher in fish fed the T20 diet compared to C+ and C− diets. Overall, it seems that high dietary taurine supplementation acted as a growth promoter and concurrently improved significantly the postharvest quality characteristics of seabass, which may be attributed to its role in maintaining cell membrane integrity and permeability.
Comparing ultrafiltration and equilibrium dialysis to measure unbound plasma dolutegravir concentrations based on a design of experiment approach
Authors: Metsu David , Lanot Thomas , Fraissinet François , Concordet Didier , Gayrard Véronique , Averseng Manon , Ressault Alice , Martin-Blondel Guillaume , Levade Thierry , Février Frédéric , Chatelut Etienne , Delobel Pierre , Gandia Peggy 
Published: July 2020

AbstractDolutegravir therapeutic drug monitoring (TDM) could be improved by measuring the unbound dolutegravir plasma concentration (Cu), particularly in patients experiencing virological failure or toxicity despite achieving appropriate DTG total plasma concentrations. Equilibrium dialysis (ED) is the gold standard to measure Cu, but ED is time consuming, precluding its use in clinical practice. In contrast, ultrafiltration is applicable to TDM, but is sensitive to numerous analytical conditions. In order to evaluate measurements of Cu by ultrafiltration, ultrafiltration conditions were validated by comparison with ED. DTG concentrations were measured by LC–MS/MS. Three ultrafiltration factors (temperature, duration and relative centrifugal force [RCF]) were evaluated and compared to ED (25/37 °C), using a design of experiment strategy. Temperature was found to influence Cu results by ED (p = 0.036) and UF (p = 0.002) when results were analysed with ANOVA. Relative centrifugal force (2000 g) and time (20 min) interacted to influence Cu (p = 0.006), while individually they did not influence Cu (p = 0.88 and p = 0.42 for RCF and time). Ultrafiltration conditions which yielded the most comparable results to ED were 37 °C, 1000 g for 20 min. Ultrafiltration results greatly depended on analytical conditions, confirming the need to validate the method by comparison with ED in order to correctly interpret DTG Cu.
Transcriptomic differences between male and female Trachycarpus fortunei
Authors: Feng Xiao , Yang Zhao , Xiu-rong Wang , Ying Wang 
Published: July 2020

AbstractTrachycarpus fortunei (Hook.) is a typical dioecious plant, which has important economic value. There is currently no sex identification method for the early stages of T. fortunei growth. The aim of this study was to obtain expression and site differences between male and female T. fortunei transcriptomes. Using the Illumina sequencing platform, the transcriptomes of T. fortunei male and female plants were sequenced. By analyzing transcriptomic differences, the chromosomal helical binding protein (CHD1), serine/threonine protein kinase (STPK), cytochrome P450 716B1, and UPF0136 were found to be specifically expressed in T. fortunei males. After single nucleotide polymorphism (SNP) detection, a total of 12 male specific sites were found and the THUMP domain protein homologs were found to be male-biased expressed. Cytokinin dehydrogenase 6 (CKX6) was upregulated in male flowers and the lower concentrations of cytokinin (CTK) may be more conducive to male flower development. During new leaf growth, flavonoid and flavonol biosynthesis were initiated. Additionally, the flavonoids, 3′,5′-hydroxylase (F3′5′H), flavonoids 3′-hydroxylase, were upregulated, which may cause the pale yellow phenotype. Based on these data, it can be concluded that inter-sex differentially expressed genes (DEGs) and specific SNP loci may be associated with sex determination in T. fortunei.
A preliminary investigation into the use of molecular oxide and hydride secondary ion relationships for improvement of the 236U/238U determination on a NanoSIMS 50L
Authors: Zirakparvar N. Alex , Hexel Cole R. , Smith Julie B. , Miskowiec Andrew J. , Spano Tyler L. , Kapsimalis Roger 
Published: July 2020

AbstractA NanoSIMS 50L is used to investigate uranium molecular (235U16O, 236U16O, 238U16O, 235U1H, 238U1H, 236U16O1H, and 238U16O1H) and elemental (235U, 236U, and 238U) secondary ion production during sputtering of synthetic UO2 and the NIST-610 standard to determine if: (1) the 236U16O/238U16O molecular oxide ratio performs better than the 236U/238U elemental ratio, and (2) there is co-variance between the molecular hydrides and oxides. Despite an order of magnitude greater abundance of 236U16O secondary ions (compared to 236U), the 236U16O/238U16O ratios are less accurate than the 236U/238U ratios. Further work is needed before the higher count rate of the 236U16O secondary ion can be used to obtain a better 236U/238U ratio. The second objective was undertaken because correction for the interference of 235U1H on the 236U secondary ion species typically utilizes the 238U1H/238U ratio. This becomes problematic in samples containing 239Pu, so our aim was to understand if the hydride formation rate can be constrained independently of having to measure the 238U1H. We document correlations between the hydride (238U1H and 238U16O1H) and oxide (236U16O) secondary ions, suggesting that pursuing an alternative correction regime is worthwhile.
Nano assembly of NiFe spheres anchored on f-MWCNT for electrocatalytic reduction and sensing of nitrofurantoin in biological samples
Authors: Hwa Kuo-Yuan , Sharma Tata Sanjay Kanna 
Published: July 2020

AbstractThe current study reports a facile simple, low-cost electrochemical sensor in the detection of nitrofurantoin (NFT) by using NiFe/f-MWCNT hybrid composite as a promising electrocatalyst. NFT is an antibiotic drug that is extensively using in pharmaceuticals and also in animal food production which causes a severe threat for both human and animal environments. Extending the residues of NFT are left into rivers, soils, lakes, and groundwaters either found or discharged leading health issues. To this NiFe/f-MWCNT composite was synthesized using a hydrothermal mechanism and then ultrasonicated to form a hybrid composite for catalytic evaluation and electrochemical detection of NFT for the very first time. Furthermore, the physicochemical properties of NiFe nanospheres conjugated on f-MWCNT are scrutinized using various analytical and spectroscopical techniques. Resulting transmission electron microscopy (TEM) displays a chain like NiFe nanospheres anchored on f-MWCNT with a well-defined spherical shape, without any comprehensive agglomeration. The NiFe/f-MWCNT screen printed carbon paste electrode (SPCE) displayed an excellent electrocatalytic activity for NFT with a LOD of 0.03 µM and a sensitivity of 11.45 µA µM−1 cm−2. establishing a new selectivity and with the existence of co-interfering compounds. To enhance the practical abilities analysis were performed in Human serum and urine samples which resulted in satisfactory recoveries with high precision and linear accuracy illustrated in Scheme 1.