bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of an Early Cognitive-Behavioral Intervention for Acute Stress Disorder in Mexican Earthquake Victims
Authors: Durón-Figueroa Raúl , Cárdenas-López Georgina , Quero Soledad 
Published: October 2020

Abstract
Acute stress disorder (ASD) refers to the symptoms associated with posttraumatic stress disorder (PTSD) within the first four weeks following the traumatic event. Recent theoretical models suggest that early detection of ASD provides an opportunity to implement early interventions to prevent the development of PTSD or ameliorate its symptomatology. The aim of the present study was the evaluation of the efficacy of an ASD treatment for earthquake victims, which would serve as an early intervention for PTSD. A single-case (n = 1) quasi-experimental design was used, with pre and post-assessments, as well as one, three and six-month follow-ups, with direct treatment replications. Fourteen participants completed the treatment and the follow-up measurements. The results obtained using a single-case analysis showed significant clinical improvement and clinically significant change when employing a clinical significance analysis and the reliable index of change. Statistical analyses of the dataset displayed statistically significant differences between the pre and post-assessments and the follow-up measures, as well as large effect sizes in all clinical measures. These results suggest that the treatment was an efficacious early intervention for PTSD during the months following the traumatic event, although some relevant study limitations are discussed in the text.
Convective Aggregation and the Amplification of Tropical Precipitation Extremes
Authors: Dai Ni , Soden Brian J. 
Published: October 2020

AbstractIt is widely believed that precipitation extremes will increase in response to a warming climate, as inferred from both observations and numerical simulations. In the absence of changes in atmospheric circulations, extreme precipitation is expected to increase in already‐moist regions along a thermodynamical Clausius‐Clapeyron scaling. However, within the tropics, the sensitivities inferred from observations of interannual variability are roughly twice as large, implying an unknown contribution from atmospheric dynamics. In this paper, we use satellite observations and climate model simulations to investigate the relationship between convective aggregation and precipitation and the role that convective aggregation plays in amplifying the response of tropical precipitation extremes to interannual surface warming. We find that the occurrence of heavier precipitation coincides with a higher degree of convective aggregation. Extreme precipitation events and convective aggregation tend to increase during warm, El Niño events compared to colder, La Niña events. Although both the frequency and intensity of heavy to extreme precipitation can increase with increased aggregation during El Niño, the changes in frequency are more consistent among the observations and models than changes in intensity. In both the observations and models, increases in large‐scale convective aggregation contribute to roughly one third of the increase in extreme precipitation frequency due to interannual warming by shifting moderate‐to‐heavy precipitation events to more extreme precipitation intensities. The linkages between convective aggregation and precipitation extremes considered here offer insights into their potential response to anthropogenic warming.
Sensitivity of Atmospheric River Vapor Transport and Precipitation to Uniform Sea Surface Temperature Increases
Authors: McClenny Elizabeth E. , Ullrich Paul A. , Grotjahn Richard 
Published: October 2020

AbstractFilaments of intense vapor transport called atmospheric rivers (ARs) are responsible for the majority of poleward vapor transport in the midlatitudes. Despite their importance to the hydrologic cycle, there remain many unanswered questions about changes to ARs in a warming climate. In this study we perform a series of escalating uniform SST increases (+2, +4, and +6K, respectively) in the Community Atmosphere Model version 5 in an aquaplanet configuration to evaluate the thermodynamic and dynamical response of AR vapor content, transport, and precipitation to warming SSTs. We find that AR column integrated water vapor (IWV) is especially sensitive to SST and increases by 6.3–9.7% per degree warming despite decreasing relative humidity through much of the column. Further analysis provides a more nuanced view of AR IWV changes: Since SST warming is modest compared to that in the midtroposphere, computing fractional changes in IWV with respect to SST results in finding spuriously large increases. Meanwhile, results here show that AR IWV transport increases relatively uniformly with temperature and at consistently lower rates than IWV, as modulated by systematically decreasing low‐level wind speeds. Similarly, changes in AR precipitation are related to a compensatory relationship between enhanced near‐surface moisture and damped vertical motions.
Improved Fabry‐Pérot Electromagnetic Material Characterization: Application and Results
Authors: Possenti L. , Pascual‐García J. , Degli‐Esposti V. , Lozano‐Guerrero A. , Barbiroli M. , Martinez‐Inglés M. T. , Fuschini F. , Rodríguez J. V. , Vitucci E. M. , Molina‐García‐Pardo J. M. 
Published: October 2020

AbstractWhile several mm‐wave and sub‐THz frequency bands are being proposed for next generation wireless systems to meet the increasing traffic demand, the electromagnetic properties of many common use materials at those frequencies still need to be determined. The evaluation of such properties is important for the design and deployment of future wireless networks. Recently, a simple method based on Fabry‐Pérot resonance has been proposed to address the need of easy material characterization at mm‐wave frequencies. In this study, the method has been improved and applied to the characterization of several materials at mm‐wave and sub‐THz frequencies, in order to assess its reliability, usability, and accuracy in practical cases. The method is shown to achieve a good accuracy level despite the very simple measurement setup and the great flexibility. However, some application limitations are highlighted and discussed in the paper. A method for electromagnetic material characterization based on an improved Fabry‐Pérot technique is presented.
β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis
Authors: Yoo Jung-Yoon , Ku Bon Jeong , Kim Tae Hoon , Il Ahn Jong , Ahn Ji Yeon , Yang Woo Sub , Lim Jeong Mook , Taketo Maketo M. , Shin Jung-Ho , Jeong Jae-Wook 
Published: October 2020

AbstractAdenomyosis is defined as the presence of ectopic nests of endometrial glands and stroma within the myometrium. Adenomyosis is a common cause of dysmenorrhea, menorrhagia, and chronic pelvic pain but is often underdiagnosed. Despite its prevalence and severity of symptoms, its pathogenesis and etiology are poorly understood. Our previous study showed that aberrant activation of β-catenin results in adenomyosis through epithelial–mesenchymal transition. Using transcriptomic and ChIP-seq analysis, we identified activation of TGF-β signaling in the uteri of mutant mice that expressed dominant stabilized β-catenin in the uterus. There was a strong positive correlation between β-catenin and TGF-β2 proteins in women with adenomyosis. Furthermore, treatment with pirfenidone, a TGF-β inhibitor, increased E-cadherin expression and reduced cell invasiveness in Ishikawa cells with nuclear β-catenin. Our results suggest that β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis. This finding describes the molecular pathogenesis of adenomyosis and the use of TGF-β as a potential therapeutic target for adenomyosis.
Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?
Authors: Pozzi Davide , Rasile Marco , Corradini Irene , Matteoli Michela 
Published: October 2020

AbstractChloride homeostasis, the main determinant factor for the dynamic tuning of GABAergic inhibition during development, has emerged as a key element altered in a wide variety of brain disorders. Accordingly, developmental disorders such as schizophrenia, Autism Spectrum Disorder, Down syndrome, epilepsy, and tuberous sclerosis complex (TSC) have been associated with alterations in the expression of genes codifying for either of the two cotransporters involved in the excitatory-to-inhibitory GABA switch, KCC2 and NKCC1. These alterations can result from environmental insults, including prenatal stress and maternal separation which share, as common molecular denominator, the elevation of pro-inflammatory cytokines. In this review we report and systemize recent research articles indicating that different perinatal environmental perturbations affect the expression of chloride transporters, delaying the developmental switch of GABA signaling, and that inflammatory cytokines, in particular interleukin 1β, may represent a key causal factor for this phenomenon. Based on literature data, we provide therefore a unifying conceptual framework, linking environmental hits with the excitatory-to-inhibitory GABA switch in the context of brain developmental disorders.
Recent fall Eurasian cooling linked to North Pacific sea surface temperatures and a strengthening Siberian high
Authors: Li Baofu , Li Yupeng , Chen Yaning , Zhang Baohuan , Shi Xun 
Published: October 2020

AbstractWinter Eurasian cooling after the mid-1990s has been verified by numerous studies, although in recent decades, the mid-latitudes of the Northern Hemisphere have been rapidly warming globally. Because the cooling is not uniform at different spatial and temporal scales, over time, this change may not truly reflect the nature of climate fluctuations. Here, by using three types of data (reanalysis, weather station, and remote sensing image data) to assess variations in Eurasian seasonal cooling, we examine the causes of these changes. During a 30-year climatology (1989–2018), we show that a significant (P < 0.05) abrupt change in the autumn Eurasian air temperature trend occurred in 2003. Our results suggest that from 2004–2018, the autumn Eurasian temperature reveals a significant cooling trend (P < 0.05). We demonstrate that the autumn cooling in Eurasia is likely influenced by the Pacific Decadal Oscillation (PDO) and Siberian high (SH). Since 2004, the strengthening of the PDO and SH explains approximately 54% and 18% of the autumn cooling in Eurasia, respectively. We also find that the cooling in autumn is stronger than that in winter.
MIR2111-5 locus and shoot-accumulated mature miR2111 systemically enhance nodulation depending on HAR1 in Lotus japonicus
Authors: Okuma Nao , Soyano Takashi , Suzaki Takuya , Kawaguchi Masayoshi 
Published: October 2020

AbstractLegumes utilize a shoot-mediated signaling system to maintain a mutualistic relationship with nitrogen-fixing bacteria in root nodules. In Lotus japonicus, shoot-to-root transfer of microRNA miR2111 that targets TOO MUCH LOVE, a nodulation suppressor in roots, has been proposed to explain the mechanism underlying nodulation control from shoots. However, the role of shoot-accumulating miR2111s for the systemic regulation of nodulation was not clearly shown. Here, we find L. japonicus has seven miR2111 loci, including those mapped through RNA-seq. MIR2111-5 expression in leaves is the highest among miR2111 loci and repressed after rhizobial infection depending on a shoot-acting HYPERNODULATION ABERRANT ROOT FORMATION1 (HAR1) receptor. MIR2111-5 knockout mutants show significantly decreased nodule numbers and miR2111 levels. Furthermore, grafting experiments using transformants demonstrate scions with altered miR2111 levels influence nodule numbers in rootstocks in a dose-dependent manner. Therefore, miR2111 accumulation in leaves through MIR2111-5 expression is required for HAR1-dependent systemic optimization of nodule number.
Observation of phonon trapping in the continuum with topological charges
Authors: Tong Hao , Liu Shengyan , Zhao Mengdi , Fang Kejie 
Published: October 2020

AbstractPhonon trapping has an immense impact in many areas of science and technology, from the antennas of interferometric gravitational wave detectors to chip-scale quantum micro- and nano-mechanical oscillators. It usually relies on the mechanical suspension—an approach, while isolating selected vibrational modes, leads to serious drawbacks for interrogation of the trapped phonons, including limited heat capacity and excess noises via measurements. To circumvent these constraints, we realize a paradigm of phonon trapping using mechanical bound states in the continuum (BICs) with topological features and conducted an in-depth characterization of the mechanical losses both at room and cryogenic temperatures. Our findings of mechanical BICs combining the microwave frequency and macroscopic size unveil a unique platform for realizing mechanical oscillators in both classical and quantum regimes. The paradigm of mechanical BICs might lead to unprecedented sensing modalities for applications such as rare-event searches and the exploration of the foundations of quantum mechanics in unreached parameter spaces.
A network-ready random-access qubits memory
Authors: Langenfeld Stefan , Morin Olivier , Körber Matthias , Rempe Gerhard 
Published: October 2020

AbstractPhotonic qubits memories are essential ingredients of numerous quantum networking protocols. The ideal situation features quantum computing nodes that are efficiently connected to quantum communication channels via quantum interfaces. The nodes contain a set of long-lived matter qubits, the channels support the propagation of light qubits, and the interface couples light and matter qubits. Toward this vision, we here demonstrate a random-access multi-qubit write-read memory for photons using two rubidium atoms coupled to the same mode of an optical cavity, a setup that is known to feature quantum computing capabilities. We test the memory with more than ten independent photonic qubits, observe no noticeable cross-talk, and find no need for re-initialization even after ten write-read attempts. The combined write-read efficiency is 26% and the coherence time approaches 1 ms. With these features, the node constitutes a promising building block for a quantum repeater and ultimately a quantum internet.
Optimizing practice scheduling requires quantitative tracking of individual item performance
Authors: Eglington Luke G. , Pavlik Jr Philip I. 
Published: October 2020

AbstractDecades of research has shown that spacing practice trials over time can improve later memory, but there are few concrete recommendations concerning how to optimally space practice. We show that existing recommendations are inherently suboptimal due to their insensitivity to time costs and individual- and item-level differences. We introduce an alternative approach that optimally schedules practice with a computational model of spacing in tandem with microeconomic principles. We simulated conventional spacing schedules and our adaptive model-based approach. Simulations indicated that practicing according to microeconomic principles ofefficiencyresulted in substantially better memory retention than alternatives. The simulation results provided quantitative estimates of optimal difficulty that differed markedly from prior recommendations but still supported a desirable difficulty framework. Experimental results supported simulation predictions, with up to 40% more items recalled in conditions where practice was scheduled optimally according to the model of practice. Our approach can be readily implemented in online educational systems that adaptively schedule practice and has significant implications for millions of students currently learning with educational technology.
Harmonised LUCAS in-situ land cover and use database for field surveys from 2006 to 2018 in the European Union
Authors: d’Andrimont Raphaël , Yordanov Momchil , Martinez-Sanchez Laura , Eiselt Beatrice , Palmieri Alessandra , Dominici Paolo , Gallego Javier , Reuter Hannes Isaak , Joebges Christian , Lemoine Guido , van der Velde Marijn 
Published: October 2020

AbstractAccurately characterizing land surface changes with Earth Observation requires geo-located ground truth. In the European Union (EU), a tri-annual surveyed sample of land cover and land use has been collected since 2006 under the Land Use/Cover Area frame Survey (LUCAS). A total of 1351293 observations at 651780 unique locations for 106 variables along with 5.4 million photos were collected during five LUCAS surveys. Until now, these data have never been harmonised into one database, limiting full exploitation of the information. This paper describes the LUCAS point sampling/surveying methodology, including collection of standard variables such as land cover, environmental parameters, and full resolution landscape and point photos, and then describes the harmonisation process. The resulting harmonised database is the most comprehensive in-situ dataset on land cover and use in the EU. The database is valuable for geo-spatial and statistical analysis of land use and land cover change. Furthermore, its potential to provide multi-temporal in-situ data will be enhanced by recent computational advances such as deep learning.
Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer
Authors: Suzui Nobuo , Shibata Takuya , Yin Yong-Gen , Funaki Yoshihito , Kurita Keisuke , Hoshina Hiroyuki , Yamaguchi Mitsutaka , Fujimaki Shu , Seko Noriaki , Watabe Hiroshi , Kawachi Naoki 
Published: October 2020

AbstractVisualizing the dynamics of cesium (Cs) is desirable to understand the impact of radiocesium when accidentally ingested or inhaled by humans. However, visualization of radiocesium in vivo is currently limited to plants. Herein, we describe a method for the production and purification of 127Cs and its use in visualizing Cs dynamics in a living animal. The positron-emitting nuclide 127Cs was produced using the 127I (α, 4n) 127Cs reaction, which was induced by irradiation of sodium iodide with a 4He2+ beam from a cyclotron. We excluded sodium ions by using a material that specifically adsorbs Cs as a purification column and successfully eluted 127Cs by flowing a solution of ammonium sulfate into the column. We injected the purified 127Cs tracer solution into living rats and the dynamics of Cs were visualized using positron emission tomography; the distributional images showed the same tendency as the results of previous studies using disruptive methods. Thus, this method is useful for the non-invasive investigation of radiocesium in a living animal.
Noninvasive temporal detection of early retinal vascular changes during diabetes
Authors: Saghiri Mohammad Ali , Suscha Andrew , Wang Shoujian , Saghiri Ali Mohammad , Sorenson Christine M. , Sheibani Nader 
Published: October 2020

AbstractDiabetes associated complications, including diabetic retinopathy and loss of vision, are major health concerns. Detecting early retinal vascular changes during diabetes is not well documented, and only few studies have addressed this domain. The purpose of this study was to noninvasively evaluate temporal changes in retinal vasculature at very early stages of diabetes using fundus images from preclinical models of diabetes.
Non-diabetic and Akita/+ male mice with different duration of diabetes were subjected to fundus imaging using a Micron III imaging system. The images were obtained from 4 weeks- (onset of diabetes), 8 weeks-, 16 weeks-, and 24 weeks-old male Akita/+ and non-diabetic mice. In total 104 fundus images were subjected to analysis for various feature extractions. A combination of Canny Edge Detector and Angiogenesis Analyzer plug-ins in ImageJ were utilized to quantify various retinal vascular changes in fundus images. Statistical analyses were conducted to determine significant differences in the various extracted features from fundus images of diabetic and non-diabetic animals. Our novel image analysis method led to extraction of over 20 features. These results indicated that some of these features were significantly changed with a short duration of diabetes, and others remained the same but changed after longer duration of diabetes. These patterns likely distinguish acute (protective) and chronic (damaging) associated changes with diabetes. We show that with a combination of various plugging one can extract over 20 features from retinal vasculature fundus images. These features change during diabetes, thus allowing the quantification of quality of retinal vascular architecture as biomarkers for disease progression. In addition, our method was able to identify unique differences among diabetic mice with different duration of diabetes. The ability to noninvasively detect temporal retinal vascular changes during diabetes could lead to identification of specific markers important in the development and progression of diabetes mediated-microvascular changes, evaluation of therapeutic interventions, and eventual reversal of these changes in order to stop or delay disease progression.
A site-specific map of the human plasma glycome and its age and gender-associated alterations
Authors: Merleev Alexander A. , Park Dayoung , Xie Yixuan , Kailemia Muchena J. , Xu Gege , Ruhaak L. Renee , Kim Kyoungmi , Hong Qiuting , Li Qiongyu , Patel Forum , Wan Yu-Jui Yvonne , Marusina Alina I. , Adamopoulos Iannis E. , Lal Nelvish N. , Mitra Anupum , Le Stephanie T. , Shimoda Michiko , Luxardi Guillaume , Lebrilla Carlito B. , Maverakis Emanual 
Published: October 2020

AbstractAlterations in the human glycome have been associated with cancer and autoimmunity. Thus, constructing a site-specific map of the human glycome for biomarker research and discovery has been a highly sought-after objective. However, due to analytical barriers, comprehensive site-specific glycoprofiling is difficult to perform. To develop a platform to detect easily quantifiable, site-specific, disease-associated glycan alterations for clinical applications, we have adapted the multiple reaction monitoring mass spectrometry method for use in glycan biomarker research. The adaptations allow for highly precise site-specific glycan monitoring with minimum sample prep. Using this technique, we successfully mapped out the relative abundances of the most common 159 glycopeptides in the plasma of 97 healthy volunteers. This plasma glycome map revealed 796 significant (FDR < 0.05) site-specific inter-protein and intra-protein glycan associations, of which the vast majority were previously unknown. Since age and gender are relevant covariants in biomarker research, these variables were also characterized. 13 glycopeptides were found to be associated with gender and 41 to be associated with age. Using just five age-associated glycopeptides, a highly accurate age prediction model was constructed and validated (r2 = 0.62 ± 0.12). The human plasma site-specific glycan map described herein has utility in applications ranging from glycan biomarker research and discovery to the development of novel glycan-altering interventions.