bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease
Authors: Yue Qian , Li Shang , Lei Chon Lok , Wan Huaibin , Zhang Zaijun , Hoi Maggie Pui Man 
Published: December 2024

Abstract
Drug development for Alzheimer’s disease Is extremely challenging, as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-β cascade hypothesis. More recently, advances in the development of Lecanemab, an anti-amyloid-β monoclonal antibody, have shown positive results in reducing brain A burden and slowing cognitive decline in patients with early- stage Alzheimer’s disease in the Phase III clinical trial (Clarity Alzheimer’s disease). Despite these promising results, side effects such as amyloid-related imaging abnormalities (ARIA) may limit its usage. ARIA can manifest as ARIA-E (cerebral edema or effusions) and ARIA-H (microhemorrhages or superficial siderosis) and is thought to be caused by increased vascular permeability due to inflammatory responses, leading to leakages of blood products and protein-rich fluid into brain parenchyma. Endothelial dysfunction is an early pathological feature of Alzheimer’s disease, and the blood-brain barrier becomes increasingly leaky as the disease progresses. In addition, APOE4, the strongest genetic risk factor for Alzheimer’s disease, is associated with higher vascular amyloid burden, increased ARIA incidence, and accelerated blood-brain barrier disruptions. These interconnected vascular abnormalities highlight the importance of vascular contributions to the pathophysiology of Alzheimer’s disease. Here, we will closely examine recent research evaluating the heterogeneity of brain endothelial cells in the microvasculature of different brain regions and their relationships with Alzheimer’s disease progression.
Hidden face of Parkinson’s disease: is it a new autoimmune disease?
Authors: Jo Min Gi , Kim Seon-Hee , Yun Seung Pil 
Published: December 2024

Abstract
Parkinson’s disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors, rigidity, and slowed movements. A key feature of Parkinson’s disease is the accumulation of misfolded α-synuclein, forming insoluble Lewy bodies in the substantia nigra pars compacta, which contributes to neurodegeneration. These α-synuclein aggregates may act as autoantigens, leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death. Our perspective explores the hypothesis that Parkinson’s disease may have an autoimmune component, highlighting research that connects peripheral immune responses with neurodegeneration. T cells derived from Parkinson’s disease patients appear to have the potential to initiate an autoimmune response against α-synuclein and its modified peptides, possibly leading to the formation of neo-epitopes. Recent evidence associates Parkinson’s disease with abnormal immune responses, as indicated by increased levels of immune cells, such as CD4+ and CD8+ T cells, observed in both patients and mouse models. The convergence of T cells filtration increasing major histocompatibility complex molecules, and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson’s disease may exhibit autoimmune characteristics. Understanding the immune mechanisms involved in Parkinson’s disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease. Novel approaches, including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification, could pave the way for immune-based treatments aimed at slowing or halting disease progression. This perspective explores the relationship between autoimmunity and Parkinson’s disease, suggesting that further research could deepen understanding and offer new therapeutic avenues. In this paper, it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson’s disease. It investigates critical areas such as the autoimmune response observed in Parkinson’s disease patients and the role of autoimmune mechanisms targeting α-synuclein in Parkinson’s disease. The paper also examines the impact of CD4+ T cells, specifically Th1 and Th17, on neurons through in-vitro and ex-vivo studies. Additionally, it explores how α-synuclein influences glia-induced neuroinflammation in Parkinson’s disease. The discussion extends to the clinical implications and therapeutic landscape, offering insights into potential treatments. Consequently, we aim to provide a comprehensive perspective on the autoimmune aspects of Parkinson’s disease, incorporating both supportive and opposing views on its classification as an autoimmune disorder and exploring implications for clinical applications.
ANÁLISE DOS IMPACTOS DA VIOLÊNCIA OBSTÉTRICA NA SAÚDE MENTAL DA MULHER
Authors: Almeida Nádia Barboza Santana de , Carvalho Andreia Aparecida Henriques 
Published: December 2024

Essa pesquisa tem como objetivo promover uma reflexão sobre o corpo da mulher no discurso médico e compreender a violência obstétrica a partir do sistema conceitual de Michel Foucault, especialmente nas suas obras Vigiar e Punir e Microfísica do Poder. Para isso, essa pesquisa parte da seguinte pergunta de pesquisa: Quais são os impactos da violência obstétrica na saúde mental da mulher, considerando o contexto social, cultural e institucional que legitima práticas de subordinação e medicalização do corpo feminino? Para responde-la, essa pesquisa foi realizada a partir de uma revisão bibliográfica e de pesquisa de dados recentes sobre a violência obstétrica no Brasil. Assim, temos como objetivo geral analisar, por meio de uma revisão bibliográfica, os impactos da violência obstétrica na saúde mental da mulher, relacionando-os com as dinâmicas de poder e controle exercidas pelas instituições médico-hospitalares. Ainda, definimos dois objetivos específicos, que são identificar, na literatura científica, como o biopoder e os regimes de verdade presentes no discurso médico contribuem para práticas de violência obstétrica e seus reflexos na subjetividade feminina e discutir os desdobramentos psicológicos da desconexão da mulher com seu corpo durante a gestação e o parto, promovida pela medicalização e patologização do processo, conforme relatado em estudos revisados. Ao final, mostraremos que a violência obstétrica é institucionalizada no Brasil e legitimada por um regime de verdade que confere monopólio ao discurso médico sobre o corpo da mulher grávida, retirando-lhe a dignidade e trazendo sofrimento psíquico quando esta não é mais capaz de tomar decisões sobre seu corpo.
The Impact of Education Expenditure, Gross Enrollment Ratio, Technological Innovation, and Foreign Direct Investment toward Employment and Job Mismatch
Authors: Espinas Elizabelle Alexandra , Moreno Mhikyla Isabel , Camaro Peter Jeff 
Published: December 2024

Purpose: The study aims to analyze education expenditure patterns and the impact of the number of graduates in the employment of the Philippines, and evaluate the integration of technological innovation and foreign direct investment and its relationship with employment. Moreover, future researchers can utilize this paper to understand the factors affecting employment in the Philippines.
Methodology: This research utilized a descriptive-quantitative approach to explore and statistically analyze the relationships between the variables. Secondary data was collected mainly from the World Bank Database and Bangko Sentral ng Pilipinas and utilize Ordinary Least Square regression analysis using Gretl econometric software package to quantify the impact of the factors affecting the employment sector. Results were then presented in tables and graphs.
Findings: The results showed that among the variables namely education expenditure, gross enrollment ratio, technological innovation, and foreign direct investment, education expenditure had a positive and significant impact on employment with a p-value of 0.0041. The findings show that education spending is rooted in the understanding that higher education strengthens human capital, thereby improving future employment prospects and helping to increase employment in the country. Additionally, technological innovation has a negative and significant impact on job mismatch with a p-value of 0.0104. The findings indicate that technological innovation in the Philippines lessens job mismatch and thereby positively impacts employment growth.
Contribution to Theory, Policy and Practice: The study recommended that increased education expenditure, particularly for tertiary education, can significantly improve employment outcomes. It urged CHED to advocate for higher budget allocations to enhance access, quality, and relevance of education, ensuring curricula and training meet job market demands. Additionally, while technological innovation has direct impact on employment, policies promoting innovation, such as grants and public-private partnerships, could foster skill development and create a tech-savvy workforce. The government's ongoing efforts in R&D, digitalization, and broadband expansion are steps toward preparing the workforce for evolving industries and promoting innovation.
Creative Research
Authors: Collins Hilary 
Published: December 2024

The essential step-by-step guide for artists and designers undertaking research, now with new sections on visual research and data analysis.
Academic research in practical design and the creative industries can seem daunting. In this updated edition ofCreative Research, Hilary Collins walks you through the process of creating a great research project from both practice-based and theoretical perspectives.
The perfect companion for researchers or students within the creative industries, this easy-to-follow guide covers: - Choosing a topic - Deciding your approach - Using previous research and writing a literature review - Obtaining your own data and using it appropriately - Best practice, through examples and case studies
This edition also includes new sections on speculative design, design thinking and iterative fieldwork, as well as expanded coverage of data analysis vs data synthesis, using analytics data, usability testing, developing visual research and sense-making and discourse analysis.
With advice on everything from time management and project structuring to ethnography and ethics, as well as helpful diagrams, case studies and summaries throughout, Collins marries theory and practice from start to finish to help you confidently embark on your creative research project.
Aesthetics without Objects and Subjects
Authors: Perullo Nicola 
Published: December 2024

Is there a connection between the environmental, climate, and politicalcrises facing us todayand Western dualism?By critically examining the subject/object dualism that has supported Western philosophy and aesthetics since the 17th century, Nicola Perullo presents a relational and co-operative account of aesthetic experience and human existence.
Exploring science, ontology and aesthetics through the perspectives of quantum physics’ relational interpretation and non-dualistic philosophies, Perullo draws on Western theories in anthropology and cultural traditions such as Buddhism and Daoism. We see how the ontology supported by dualism renders the world to consist of static, solid, and discrete things, making them vulnerable to be controlled, dominated, and possessed.
In Perullo’s ground-breaking analysis an alternative way of perceiving is offered: the “haptic” modality which is guided by cooperation, communication, and correspondence. Such a mode of perception and experience is ecological, precluding the possibility of domination, hierarchy, and exploitation. This challenge to the ramifications of the subject-object model, the very cornerstone of Western thought, is an exciting invitation to rethink the purpose of philosophizing and its impact on life.
At the Gates of Rome
Authors: Hollway Don 
Published: December 2024

A dramatic retelling of the final years of the Western Roman Empire and the downfall of Rome itself from the perspective of the Roman general Stilicho and Alaric, king of the Visigoths.
It took little more than a single generation for the centuries-old Roman Empire to fall. In those critical decades, while Christians and pagans, legions and barbarians, generals and politicians squabbled over dwindling scraps of power, two men – former comrades on the battlefield – rose to prominence on opposite sides of the great game of empire.
Roman general Flavius Stilicho, the man behind the Roman throne, dedicated himself to restoring imperial glory, only to find himself struggling for his life against political foes. Alaric, King of the Goths, desired to be a friend of Rome, was betrayed by it, and given no choice but to become its enemy. Battling each other to a standstill, these two warriors ultimately overcame their differences in order to save the empire from enemies on all sides. And when one of them fell, the other took such vengeance as had never been seen in history.
Don Hollway, author ofThe Last Viking, combines ancient chroniclers’ accounts of Stilicho and Alaric into an unforgettable history of betrayal, politics, intrigue and war for the heart and soul of the Roman Empire.
Cactus Air Force
Authors: Hammel Eric , Cleaver Thomas McKelvey 
Published: December 2024

Using diary entries, interviews and first-hand accounts, this vivid narrative brings to life the struggle in the air over the island of Guadalcanal between August 20 and November 15, 1942.
The battle of Guadalcanal was the first offensive operation undertaken by the US and its allies in the Pacific War. The three months of air battles between August 20, 1942, when the first Marine air unit arrived on the island, and November 15, when the last enemy attempt to retake the island was defeated, were perhaps the most important of the Pacific War. “Cactus,” the code name for the island, became a sinkhole for Japanese air and naval power, as they experienced losses that could never be made good.
For 40 years, the late Eric Hammel interviewed more than 150 American participants in the air campaign at Guadalcanal, none of whom are still alive. These interviews are the most comprehensive first-person accounts of the battle assembled by any historian. More importantly, they involved the junior officers and enlisted men whose stories and memories were not part of the official history, and thus provide a unique insight.
InThe Cactus Air Force, Pacific War expert Thomas McKelvey Cleaver worked closely with Eric to build on his collection of diary entries, interviews and first-hand accounts to create a vivid narrative of the struggle in the air over the island of Guadalcanal between August 20 and November 15, 1942.
Retention of α-pinene oxidation products and nitro-aromatic compounds during riming
Authors: Borchers Christine , Seymore Jackson , Gautam Martanda , Dörholt Konstantin , Müller Yannik , Arndt Andreas , Gömmer Laura , Ungeheuer Florian , Szakáll Miklós , Borrmann Stephan , Theis Alexander , Vogel Alexander L. , Hoffmann Thorsten 
Published: December 2024

Abstract. Riming is an important growth process of graupel and hailstones in the mixed-phase zones of clouds, during which supercooled liquid droplets freeze on the surface of ice particles by contact. Compounds dissolved in the supercooled cloud droplets can remain in the ice or be released to the gas phase during freezing, which might play an important role in the vertical redistribution of these compounds in the atmosphere by convective cloud processes. This is important for estimating the availability of these compounds in the upper troposphere, where organic matter can promote new particle formation and growth. The amount of organic material remaining in the ice phase can be described by the retention coefficient. Experiments were performed in the Mainz vertical wind tunnel under dry and wet growth conditions (temperature from −12 to −3 °C and a liquid water content (LWC) of 0.9±0.2 g m−3 and 2.2±0.2 g m−3) as well as with different pH values (4 and 5.6) to obtain the retention coefficients of α-pinene oxidation products and nitro-aromatic compounds. For cis-pinic acid, cis-pinonic acid, and (−)-pinanediol, mean retention coefficients of 0.96±0.07, 0.92±0.11, and 0.98±0.08 were obtained. 4-Nitrophenol, 4-nitrocatechol, 2-nitrobenzoic acid, and 2-nitrophenol showed mean retention coefficients of 1.01±0.07, 1.01±0.14, 0.99±0.04, and 0.21±0.12. Only the retention coefficient of 2-nitrophenol showed a dependence on temperature, growth regime, and pH. This is in accordance with previous studies, which showed a dependence between the dimensionless effective Henry's law constant H* and the retention coefficient for inorganic and small organic molecules. Our results reveal that this correlation can also be applied to more complex organic molecules and that retention under these conditions is not a significant factor for molecules with H* below 103, while retention close to 1 can be expected for compounds with H* above 108.
Estimating global precipitation fields by interpolating rain gauge observations using the local ensemble transform Kalman filter and reanalysis precipitation
Authors: Muto Yuka , Kotsuki Shunji 
Published: December 2024

Abstract. It is crucial to improve global precipitation estimates for a better understanding of water-related disasters and water resources. This study proposes a new methodology to interpolate global precipitation fields from ground rain gauge observations using the algorithm of the local ensemble transform Kalman filter (LETKF), a computationally efficient ensemble data assimilation method, in which the first guess and its error covariance are developed based on the reanalysis data of precipitation from the European Centre for Medium-Range Weather Forecasts (ERA5). For the estimation for each date, the climatological ensembles are constructed using the ERA5 data 10 years before and after that date, and thereafter they are utilized to obtain the first guess and its error covariance. Additionally, the global rain gauge observations provided by the National Oceanic and Atmospheric Administration Climate Prediction Center (NOAA CPC) are used for observation inputs in the LETKF algorithm. Our estimates have better agreements with independent rain gauge observations compared to the existing precipitation estimates of the NOAA CPC in general. Because we utilized the same rain gauge observations for the inputs of our estimation as those used in the NOAA CPC product, this indicates that the proposed estimation method is superior to that of the NOAA CPC (i.e., optimal interpolation). Our proposed method had the advantage of constructing a physically consistent first guess and its error variance using reanalysis data for interpolating precipitation fields. Furthermore, validations against independent rain gauge observations showed that our estimates are largely improved in mountainous or rain-gauge-sparse regions compared to the CPC estimates, indicating strong benefits of the proposed method for such regions.
A Blueprint for High Altitude Acclimatization Prior to High Altitude Competition for Professional Athletes
Authors: Ramchandani Rashi , Gupta Shyla , Mohammad Emaad , Florica Tereza , Rawi Reem Al , Galdeano Ricardo Sebastian , Sotomayor-Perales Jorge , Baranchuk Adrian 
Published: December 2024

Introduction: Among professional athletes, high altitude training is a popular technique due to its documented success on improving cardiovascular health and athletic performance. Nevertheless, there is little consensus on the guidelines for high altitude training and competition. This review sought to summarize existing literature for acclimatization recommendations for competing at high altitudes and suggests a blueprint that could be followed by athletes and trainers.
Methods: This paper is part of the Altitude Nondifferentiated ECG Study (ANDES) project. A non-systematic search was conducted using Pubmed, EMBASE and MEDLINE databases.
Results: Six studies were included, all of which recommended a gradual ascent before competition. The duration of acclimatization ranged from 4 days to 2 weeks depending on the magnitude of ascent. Athletes are encouraged to have pre-ascent assessments of ferritin, transferrin, hemoglobin mass, ECG, and weight with close monitoring of adverse altitude-induced complications.
Conclusion: This study provides insight on key recommendations for athletes and trainers to consider when training and competing at high altitudes. These strategies can optimize athletic performance and mitigate deleterious altitude effects that can hinder functionality and training.
Analisis kemampuan calon guru IPA mengintegrasikan teknologi dalam pembelajaran menggunakan SAMR
Authors: Abdurrahman Dudung , Nursafitri Nursafitri 
Published: December 2024

Pembelajaran di masa pandemi Covid 19 mengharuskan guru memiliki kemampuan dalam teknologi untuk mendukung pembelajaran. Pembelajaran model ini menjadi new normal dalam pendidikan. Oleh karena itu, calon guru harus memiliki kemampuan mengintegrasikan teknologi dalam pembelajaran. Penelitian ini bertujuan untuk menganalisis kemampuan calon guru IPA dalam mengintergasikan teknologi dalam pembelajaran IPA. Metode penelitian yang digunakan adalah deskriptif. Sampel pada penelitian ini adalah mahasiswa yang mengikuti perkuliahan microteaching semster ganjil 2021/2022 sebanyak 6 orang. Pofil kemampuan Â calon guru IPA dalam mengintegrasikan teknologi diperoleh dari observasi pembelajaran yang disimulasikan. Tingkatan integrasi teknologi dalam pembelajaran dikelompokan menggunakan SAMR. Hasilnya diperoleh bahwa mahasiswa calon guru IPA dalam mengintegrasikan pembelajaran masih berada pada tingkat subtitution. Pada tingkat ini, teknologi digunakan pada pembelajaran hanya sebatas pengganti dan tidak ada peningkatan fungsional teknologi di pembelajaran.
Profil argumentasi calon guru IPA pada materi energi alternatif
Authors: Abdurrahman Dudung 
Published: December 2024

Tujuan penelitian ini adalah untuk mengetahui kemampuan argumentasi calon guru IPA pada materi energi alternatif. Metode penelitian yang digunakan adalah deskriptif. Sampel pada penelitian ini adalah calon guru IPA yang mengikuti perkuliahan materi dan energiÂ sebanyak 27 orang. Kemampuan argumentasi diperoleh dari jawaban tugas mengenai energi alternatif. Argumentasi yang diperoleh di analisis komponennya menurut Toulmins Argumentation Pattern (TAP). HasilnyaÂ kemampuan argumentasi calon guru IPA pada materi energi alternatif berada pada level 2, yaitu sudah mampu membuat claim, data, dan atau warrant. Calon guru IPA yang memiliki kemampuan lebih tinggi memperoleh level argumentasi lebih tinggi. Dan koherensi antar komponen argumen dominan pada limited coherency, yaitu penjelasan yang dibuat kurang relevan dengan claim yang dibuat.