bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ni2P Nanoalloy as an Air‐Stable and Versatile Hydrogenation Catalyst in Water: P‐Alloying Strategy for Designing Smart Catalysts
Authors: Fujita Shu , Yamaguchi Sho , Yamasaki Jun , Nakajima Kiyotaka , Yamazoe Seiji , Mizugaki Tomoo , Mitsudome Takato 
Published: December 2020

AbstractNon‐noble metal‐based hydrogenation catalysts have limited practical applications because they exhibit low activity, require harsh reaction conditions, and are unstable in air. To overcome these limitations, herein we propose the alloying of non‐noble metal nanoparticles with phosphorus as a promising strategy for developing smart catalysts that exhibit both excellent activity and air stability. We synthesized a novel nickel phosphide nanoalloy (nano‐Ni2P) with coordinatively unsaturated Ni active sites. Unlike conventional air‐unstable non‐noble metal catalysts, nano‐Ni2P retained its metallic nature in air, and exhibited a high activity for the hydrogenation of various substrates with polar functional groups, such as aldehydes, ketones, nitriles, and nitroarenes to the desired products in excellent yields in water. Furthermore, the used nano‐Ni2P catalyst was easy to handle in air and could be reused without pretreatment, providing a simple and clean catalyst system for general hydrogenation reactions.
Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer
Authors: Ciarlantini Matías S. , Barquero Andrea , Bayo Juan , Wetzler Diana , Dodes Traian Martín M. , Bucci Hernán A. , Fiore Esteban J. , Gandolfi Donadío Lucía , Defelipe Lucas , Turjanski Adrián , Ramírez Javier A. , Mazzolini Guillermo , Comin Maria J. 
Published: December 2020

AbstractThe Rho GTPase Rac1 is involved in the control of cytoskeleton reorganization and other fundamental cellular functions. Aberrant activity of Rac1 and its regulators is common in human cancer. In particular, deregulated expression/activity of Rac GEFs, responsible for Rac1 activation, has been associated to a metastatic phenotype and drug resistance. Thus, the development of novel Rac1‐GEF interaction inhibitors is a promising strategy for finding new preclinical candidates. Here, we studied structure–activity relationships within a new family of N,N’‐disubstituted guanidine as Rac1 inhibitors. We found that compound 1D‐142, presents superior antiproliferative activity in human cancer cell lines and higher potency as Rac1‐GEF interaction inhibitor in vitro than parental compounds. In addition, 1D‐142 reduces Rac1‐mediated TNFα‐induced NF‐κB nuclear translocation during cell proliferation and migration in NSCLC. Notably, 1D‐142 allowed us to show for the first time the application of a Rac1 inhibitor in a lung cancer animal model.
Psychotherapy and youth suicide prevention: An interpretative phenomenological analysis of specialist clinicians' experiences
Authors: Janackovski Atanas , Deane Frank P. , Hains Alex 
Published: December 2020

AbstractThe study explored psychologists' experiences in delivering short‐term psychotherapy for suicidal adolescents and sought to clarify how these experiences fit with empirically supported interventions and the interpersonal psychological theory of suicide. Semistructured interviews were conducted with 12 psychologists' who provided short‐term psychotherapy in a suicide prevention programme for youth (12‐ to 25‐year‐olds). Interview transcripts were analysed using interpretative phenomenological analysis. Three superordinate themes were identified: (i) understand the experience and context of the suicidality and the importance of a formulation‐based approach to engagement and individualized treatment planning; (ii) involve broad support systems, and in particular families, to help the young person reduce feelings of burdensomeness and increase safety, connectedness and belonging; and (iii) improve affect regulation and reflective functioning, important not only for the young person but also for the support system to maximize the positive impact of supports via emotional coregulation and effective problem‐solving. Interventions and approaches as well as the potential underlying processes of change being targeted are discussed in light of these findings. As an example, the development of a suicide safety plan was an intervention that traversed these themes. When used as a process tool, it helped foster a collaborative, formulation, dimensional and biopsychosocial approach to treat psychopathology and suicidality and extended beyond the therapist–client dyad. Moreover, treatment needs to be extended beyond the therapist–client dyad to allow therapists to facilitate a systemic treatment response, as this was seen as a major component of interventions for suicidal youth.
Clinical assessment of non‐suicidal self‐injury: A systematic review of instruments
Authors: Faura‐Garcia Juan , Orue Izaskun , Calvete Esther 
Published: December 2020

AbstractThere has been an increase in the number of assessment instruments for non‐suicidal self‐injury (NSSI). However, previous reviews are inconsistent and do not provide a comprehensive psychometric assessment of the instruments. This study aimed to systematically assess and compare the psychometric properties of clinically relevant instruments to measure NSSI in any population. Through a systematic review guided by COSMIN and PRISMA, two searches were conducted in English and Spanish in February 2020 in 13 databases including grey literature. Of the 7,813 initial records, 152 validations were extracted. From these, 83 instruments (22 versions or adaptations) were excluded for not measuring NSSI, having no potential clinical utility or not including psychometric properties. Finally, 26 (22 versions, 35 adaptations and 19 creations) instruments measuring NSSI were included. Predominantly, the studies were North American self‐reports in English for community adolescents, adaptations or versions emanating from a small number of instruments. Twenty‐six indicators were categorized to assess NSSI. The most frequent instruments are structured interviews, and their indicators were related to NSSI function and topography. Evidence of validity and reliability was positive but limited. Despite the high number of instruments and diversity of evaluations, we found no instrument with sufficient evidence for clinical assessment. Findings broadly overview NSSI assessment instruments' current use and future improvement in clinical and research settings.
Exploring the effectiveness of a specialized therapy programme for burnout using subjective report and biomarkers of stress
Authors: Orosz Ariane , Federspiel Andrea , Eckert Anne , Seeher Christian , Dierks Thomas , Tschitsaz Armita , Cattapan Katja 
Published: December 2020

AbstractThe increasing prevalence of stress‐related disorders such as burnout urges the need for specialized treatment approaches. Programmes combining psychotherapy and regenerative interventions emerge to be the most successful. However, evaluated therapy programmes are scarce and usually involve subjective symptom quantification without consideration of physiologic parameters. The aim of the present exploratory, single‐group study was the multimodal investigation of the effectiveness of a specialized holistic therapy programme by assessing symptoms and biological markers of chronic stress. Seventy‐one in‐patients (39 men/32 women; age 46.8 ± 9.9 years) of a specialized burnout ward with the additional diagnosis of burnout (Z73.0) in conjunction with a main diagnosis of depressive disorder (F32 or F33) according to the International Classification of Diseases (ICD)‐10 were included in the study. In addition to symptomatology, the stress‐responsive biomarkers heart rate variability (HRV) and serum brain‐derived neurotrophic factor (BDNF) were measured in patients at admittance to and discharge from the burnout ward applying a 6‐week specialized treatment programme. At discharge, patients showed a significant reduction of symptom burden and a significant increase in serum BDNF, while HRV remained unchanged. The findings implicate that the therapy programme may have beneficial effects on symptomatology and neuroplasticity of patients with burnout. As therapy was often supplemented by psychopharmacological treatment, a relevant influence of antidepressant medication especially on BDNF has to be considered.
Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study
Authors: Lang Jennifer , Vincent Ludwig , Chenel Marylore , Ogungbenro Kayode , Galetin Aleksandra 
Published: December 2020

Clinical assessment of drug–drug interactions (DDIs) in children is not a common practice in drug development. Therefore, physiologically‐based pharmacokinetic (PBPK) modeling can be beneficial for informing drug labeling. Using ivabradine and its metabolite (both cytochrome P450 3A4 enzyme (CYP3A4) substrates), the objectives were (i) to scale ivabradine‐metabolite adult PBPK/PD to pediatrics, (ii) to predict the DDIs with a strong CYP3A4 inhibitor, and (iii) to compare the sensitivity of children to DDIs using two CYP3A4 hepatic ontogeny functions: Salem and Upreti. A scaled parent‐metabolite PBPK/PD model from adults to children satisfactorily predicted pharmacokinetics (PK) and pharmacodynamics (PD) in 74 children (0.5–18 years) regardless of CYP3A4 hepatic ontogeny function applied. However, using the Salem ontogeny, mean predicted parent and metabolite area under the concentration‐time curve over 12 hours (AUC12h) and heart rate change from baseline were 2‐fold, 1.5‐fold, and 1.4‐fold higher in young children (0.5–3 years old) compared with Upreti ontogeny, respectively. Despite these differences, choice of appropriate hepatic CYP3A4 ontogeny was challenging due to sparse PK and PD data. Different sensitivity to ivabradine–ketoconazole DDIs was simulated in young children relative to adults depending on the choice of hepatic CYP3A4 ontogeny. Predicted ivabradine and metabolite AUCDDI/AUCcontrol were 2‐fold lower in the youngest children (0.5–1 year old) compared with adults (Salem function). In contrast, the Upreti function predicted comparable ivabradine DDIs across all age groups, although predicted metabolite AUCDDI/AUCcontrol was 1.3‐fold higher between the youngest children and adults. In the case of PD, differences in predicted DDIs were minor across age groups and between both functions. Current work highlights the importance of careful consideration of hepatic CYP3A4 ontogeny function and implications on labeling recommendations in the pediatric population.
Stability of synthetic cathinones in clinical and forensic toxicological analysis—Where are we now?
Authors: Aldubayyan Abdulaziz A. , Castrignanò Erika , Elliott Simon , Abbate Vincenzo 
Published: December 2020

AbstractUnderstanding the stability of analyzed drugs in biological samples is a crucial part for an appropriate interpretation of the analytical findings. Synthetic cathinones, as psychoactive stimulants, belong to a major class of new psychoactive substances. As they are subject to several degradation pathways, they are known to clinical and forensic toxicologists as unstable analytes in biological samples. When interpreting analytical data of synthetic cathinones in biological samples, analysts must be aware that the concentration of analytes may not accurately reflect the levels at the time they were acquired owing to many factors. This review provides (i) an overview of the current scientific knowledge on the stability of synthetic cathinones and/or metabolites in various human biological samples with a focus on factors that may deteriorate their stability—such as storage temperature, length of storage, matrix, pH, type of preservatives, concentration of analytes, and the chemistry of the analytes—and (ii) possible solutions on how to avoid such degradation. The PubMed database as well as Google Scholar was thoroughly searched to find published studies on the stability of synthetic cathinones since 2007 by searching specific keywords. A total of 23 articles met the inclusion criteria and were included in this review. Synthetic cathinones that carry methylenedioxy or N‐pyrrolidine ring showed higher degradation resistance over other substituted groups. Acidification of samples pH plays a crucial role at increasing the stability of cathinones even with analytes that were frequently considered as poorly stable. This review also provides several recommendations for best practice in planning the experimental design, preservation, and storage conditions in order to minimize synthetic cathinones' degradation in human biological samples.
Disordered eating attitudes and body shape concerns among North Indian Kathak dancers
Authors: Kulshreshtha Monika , Babu Nandita , Goel Neha J. , Chandel Shivani 
Published: December 2020

AbstractObjectiveTo determine the prevalence and association between disordered eating attitudes and body shape concerns in a sample of North Indian Kathak dancers.MethodParticipants were 206 Kathak female dancers and 235 healthy controls, ages 18–45 years. Participants completed questionnaires assessing demographics, disordered eating attitudes, and body dissatisfaction. Pearson correlations assessed the association between the disordered eating attitudes and body dissatisfaction, and binary logistic regression identified the risk of having a possible eating disorder.ResultsKathak dancers reported significantly greater disordered eating attitudes compared to controls (12.1% vs. 5.9%, p = .023). Dancers endorsed greater dieting behaviors (M = 5.6 vs. 4.5, p = .031), and binge eating episodes (p < .001) relative to their counterparts. Body dissatisfaction was significantly positively correlated with disordered eating attitudes among the dancers (p < .001). Dancers with elevated body shape concerns were five times more likely to report disordered eating attitudes, relative to their peers (p < .001).DiscussionDisordered eating attitudes and body shape concerns are prevalent among North Indian Kathak dancers. Future research should aim to develop targeted prevention and intervention programs that focus on reducing these behaviors and promoting a positive body image to mitigate the risk of disordered eating among this group.
The project COMPASS protocol: Optimizing mindfulness and acceptance‐based behavioral treatment for binge‐eating spectrum disorders
Authors: Juarascio Adrienne S. , Felonis Christina R. , Manasse Stephanie M. , Srivastava Paakhi , Boyajian Laura , Forman Evan M. , Zhang Fengqing 
Published: December 2020

AbstractOutcomes from cognitive behavioral therapy for binge‐eating spectrum disorders are suboptimal, possibly due in part to deficits in self‐regulation (i.e., the ability to control behavior in pursuit of long‐term goals despite internal challenges). Mindfulness and acceptance‐based treatments (MABTs) integrate behavioral treatment with psychological strategies designed to enhance self‐regulation, yet little is known about how and for whom they are effective. The present study will utilize the multiphase optimization strategy to identify which of four MABT components (mindful awareness, distress tolerance, emotion modulation, values‐based decision making) to include in a fully powered clinical trial. Participants (n = 256) will be randomized to 16 sessions in one of 16 conditions, each a different combination of MABT components being included or excluded from a base behavioral treatment. Our primary aim is to evaluate each component's independent efficacy on disordered eating symptoms. Our secondary aims are to confirm each component's target engagement (i.e., whether each component improves the targeted variable and outcomes), and test that each component's efficacy is moderated by baseline weaknesses in the same component (e.g., that participants with poor distress tolerance at baseline benefit most from the distress tolerance component). Our exploratory aim is to quantify the component interaction effects.
Effects of fire on ground‐dwelling arthropods in a shrub‐dominated grassland
Authors: Butler Anna , Davis Craig A. , Fuhlendorf Samuel D. , Wilder Shawn M. 
Published: December 2020

AbstractArthropods are abundant and diverse animals in many terrestrial food webs. In western Oklahoma, some shrublands are interspersed with discrete, dense thickets of tall, woody vegetation, known as mottes. Some of these shrublands are managed with prescribed burning. The goal of this study was to examine whether prescribed burning interacted with habitat type (i.e., shrubland versus mottes) to affect ground‐dwelling arthropod communities. Arthropods were collected in pitfall traps at four sampling locations in relation to mottes; in the center of mottes, and three plot location in shrublands; 1 m, 15 m, and 50 m away from the edge of the motte. There were three treatment levels for burning: one year postburn (burned in dormant months of 2017), two years postburn (burned in dormant months of 2016), and unburned (burned in dormant season of 2014 and prior). There were no significant interactions between prescribed burning and habitat type. Mottes had a different community of arthropods compared with the surrounding shrubland. Mottes also had lower overall abundance, but a higher diversity of arthropods. In terms of fires, arthropod communities one year after burning were different from those two or more years after burning. There was no effect of burning on overall arthropod abundance, but plots that were one year since burning had significantly lower diversity compared with plots that were two or more years postburn. The results of this study suggest that both fire and mottes can independently facilitate heterogeneity in arthropod communities, but they do not appear to interact with one another.
Increased mortality and worse cardiac outcome of acute myocardial infarction during the early COVID‐19 pandemic
Authors: Primessnig Uwe , Pieske Burkert M. , Sherif Mohammad 
Published: December 2020

AbstractAimsThis study aimed to evaluate the impact of coronavirus disease 2019 (Covid‐19) outbreak on admissions for acute myocardial infarction (AMI) and related mortality, severity of presentation, major cardiac complications and outcome in a tertiary‐care university hospital in Berlin, Germany.Methods and resultsIn a single‐centre cross‐sectional observational study, we included 355 patients with AMI containing ST‐elevation or non‐ST‐elevation myocardial infarction (STEMI or NSTEMI), admitted for emergency cardiac catheterization between January and April 2020 and the equivalent time in 2019. During the early phase of the Covid‐19 pandemic (e‐COV) in Berlin (March and April 2020), admissions for AMI halved compared with those in the pre‐Covid‐19 time (January and February 2020; pre‐COV) and with those in the corresponding months in 2019. However, mortality for AMI increased substantially from 5.2% pre‐COV to 17.7% (P < 0.05) during e‐COV. Severity of presentation for AMI was more pronounced during e‐COV [increased levels of cardiac enzymes, reduced left ventricular ejection fraction (LVEF), an increase in the need of inotropic support by 25% (P < 0.01)], while patients' demographic and angiographic characteristics did not differ between pre‐COV and e‐COV. Time from symptom onset to first medical contact was prolonged in all AMI during e‐COV (presentation > 72 h +21% in STEMI, p = 0.04 and presentation > 72 h in NSTEMI +22%, p = 0.02). Door to balloon time was similar in STEMI patients, while time from first medical contact to revascularization was significantly delayed in NSTEMI patients (p = 0.02). Major cardiac complications after AMI occurred significantly more often, and cardiac recovery was worse in e‐COV than in pre‐COV, demonstrated by a significantly lower LVEF (39 ± 16 vs. 46 ± 16, p < 0.05) at hospital discharge and substantially higher NTproBNP levels.ConclusionsThe Covid‐19 outbreak affects hospital admissions for acute coronary syndromes. During the first phase of the pandemia, significantly less patients with AMI were admitted, but those admitted presented with a more severe phenotype and had a higher mortality, more complications, and a worse short‐term outcome. Therefore, our data indicate that Covid‐19 had relevant impact on non‐infectious disease states, such as acute coronary syndromes.
Two year outcome in nonagenarians undergoing percutaneous mitral valve repair
Authors: Christidi Aikaterini , Haschemi Jafer , Spieker Maximilian , Bönner Florian , Kelm Malte , Westenfeld Ralf , Horn Patrick 
Published: December 2020

AbstractAimsPercutaneous mitral valve repair (PMVR) has emerged as standard treatment in selected patients with clinically relevant mitral regurgitation (MR) and increased surgical risk. We aimed to evaluate the safety and clinical outcomes in nonagenarians undergoing PMVR.Methods and resultsAltogether, 493 patients with severe MR who were treated with PMVR were included in this open‐label prospective study and followed up for 2 years. We treated 25 patients with PMVR aged 90 years or above, 185 patients aged 80–89 years, and 283 patients aged <80 years. PMVR in nonagenarians was safe and did not differ from PMVR in younger patients in terms of safety endpoints. Device success did not differ among the groups (100% in nonagenarians, 95.7% in octogenarians, and 95.1% in septuagenarians, P = 0.100). Unadjusted 2 year mortality was 28% in nonagenarians, 32.4% in octogenarians, and 19.8% in septuagenarians (P = 0.008). Kaplan–Meier curves confirmed similar 2 year survival in the nonagenarian and octogenarian groups (P = 0.657). In the multivariate analysis, age [hazard ratio (HR) 1.031, 95% confidence interval (CI) 1.002–1.060, P = 0.034], higher post‐procedural transmitral valve gradients (HR 1.187, 95% CI 1.104–1.277, P = 0.001), and post‐procedural acute kidney injury (HR 2.360, 95% CI 1.431–3.893, P = 0.001) were independent predictors of 2 year mortality. Altogether, 89.4% of the nonagenarians, 85.9% of the octogenarians, and 86.4% of the septuagenarians had MR grade of 2+ or less at 1 year after PMVR (P = 0.910). New York Heart Association functional class improved in the vast majority of patients, irrespective of age (P = 0.129). After 1 year, 9.5% of the nonagenarians, 22.3% of the octogenarians, and 25.2% of the septuagenarians (each P = 0.001 compared with baseline) suffered from New York Heart Association Functional Class III or IV. The rate of heart failure rehospitalization in the first 12 months after PMVR did not differ among the groups (16% in the nonagenarians, 16.7% in the octogenarians, and 17.7% in the septuagenarians) (P = 0.954). Quality of life assessed by the Minnesota Living with Heart Failure Questionnaire before and at 1 year after PMVR improved in all age groups (P = 0.001).ConclusionsPercutaneous mitral valve repair in carefully selected nonagenarians is feasible and safe with intermediate‐term beneficial effects comparable with those in younger patients.