bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Possibility of Using the Method of UV Spectrophotometry for the Development of Quantitative Determination of Naftifine Hydrochloride in its Solution with a Combination of PEG for the Treatment of Fungal Infections
Authors: Kosenkova S. I. , Krasnyuk I. I. , Krasnyuk (jr.) I. I. , Belyatskaya A. V. , Stepanova O. I. , Naryshkin S. R. 
Published: February 2020

Introduction. An innovative antifungal agent based on hydrochloride with combination of PEG-400 and PEG-1000 has been developed based at the chairs of Sechenov University. This solution is designated for external application as an antifungal agent. Naftifine hydrochloride has a broad spectrum of action against various fungi capable of causing onychomycosis. PEGs, forming part of the developed dosage form, bring about necessary viscosity of the solution (for retention in application area) and do not prevent drug product performance. Naftifine hydrochloride has an apparent UV absorption band with maximum of 256 ± 2 mn, in connection with this, it is supposed to use the UV spectrophotometry method for further development of quantitation method of naftifine hydrochloride detection in tested oral liquid.Aim. To evaluate the feasibility of using the UV spectrophotometry method for development of quantitation of naftifine hydrochloride in its solution with a combination of PEG for mycotic infection treatment.Materials and methods. The substance of naftifine hydrochloride, PEG-400 and PEG-1000, ethyl alcohol 96 %, UV spectrophotometry, «Millipore» filter.Results and discussion. A set of operations was carried out with UV spectrophotometer, including trials of solutions of initial substance of naftifine hydrochloride, PEG solutions, a solution of developed prolonged antimycotic drug and its placebo. The identity of UV spectra of the actual substance in various media was determined, maximum absorption of actual substance and dependence preservation between specified concentration and optical density of the solution were proved. It was found that auxiliary substances included in liquid dosage form do not affect the main characteristics of the UV spectrum of actual substance.Conclusion. The possibility in principle of using the UV spectrophotometry method for quantitative and qualitative analysis of innovative prolonged antimycotic drug – liquid dosage form of naftifine hydrochloride with a combination of PEG has been established.
Application of Luminescent Microscopy in Analysis of Anatomic-diagnostic Signs of Fruits of Sea Buckthorn
Authors: Trineeva O. V. , Gudkova A. A. , Rudaya M. A. 
Published: February 2020

Introduction. Sea buckthorn (Hippophae rhamnoides), the family Eleagnaceae – a promising source of biologically active substances, the traditional raw materials of which are fruits. The existing regulatory documentation (ND) lacks such an indicator of the authenticity and good quality of the fruit as «microscopy». Despite the available data on the anatomy and histology of the fruits of this type of medicinal plant material (MPM), the scientific literature does not describe the luminescence features of the tissues of sea buckthorn fruit. It is known that the luminescent features of tissues make it possible to identify the localization of biologically active structures, and also, in some cases, to conduct selective diagnosis of MPM.Aim. The aim of this work was to study the characteristics of the luminescence of the tissues of dried crushed fruits of sea buckthorn, and also to optimize the conditions for analysis.Materials and methods. The object of the study was the dried, crushed fruits of sea buckthorn of various species. The study of microdiagnostic signs was carried out according to the State Pharmacopoeia of the XIV RF GPA.1.5.3.0003.15 «Technique of microscopic and microchemical studies of medicinal plant materials and herbal medicines». A stereomicroscopic study was carried out on a Biomed-6 microscope. The luminescence of sea buckthorn fruit tissues was examined using a luminescent microscope of the Micromed-3 Lum brand.Results and discussion. The most pronounced yellow glow is observed for the tissue of the pulp and epidermis of the fetus, which is associated with the highest content of fatty oil in these structures. Groups of phenolic compounds contained along with oil give a greenish tint to objects, while condensed tannins give a brownish tint. The plates that make up the corymbose hairs do not exhibit bright luminescence; a weak glow is characteristic of the joints of the hair platelets. The walls of stellate hairs have a faint greenish glow. Fragments of the actual fruit («sac») are brownish in color, without their own luminescence, as well as the seed peel. The embryo has its own greenish luminescence due to the presence of both a fatty oil and a complex of storage substances.Conclusion. The luminescent analysis of sea buckthorn fruits was carried out for the first time. The choice of a method for preparing the studied MPM for microscopic examination is experimentally substantiated. The luminescent analysis revealed the peculiarities of the glow of the tissues of the fruits of sea buckthorn. The main microdiagnostic signs of crushed dried sea buckthorn fruits and their biometric characteristics are specified. The analysis of the obtained data will allow us to further develop the section «Microscopic signs» for inclusion in the PA project on MPM, widely cultivated and used by the domestic pharmaceutical industry for the production of herbal medicines.
Formation of Docetaxel-related Substances in the Polymer Particles During Storage and Gamma-treatment
Authors: Poltavets Yu. I. , Aleshin S. V. , Zavarzina V. V. , Murav’eva A. I. , Soboleva A. A. , Tubasheva I. A. , Kuznetsov S. L. 
Published: February 2020

Introduction. Docetaxel is widely used for cancer treatment. Actual issue for newly developed polymer-based Docetaxel formulations is applicability of current quality requirements. The technology of polymeric forms, including gamma-sterilization, are differ from actual Docetaxel injections technology. In this study were used PLGA-based particles with Docetaxel. The main attention was directed to studying qualitative and quantitative content of related impurities in polymeric forms during long-term storage and gamma-sterilization in comparison with pharmacopoeial requirements for Docetaxel injections.Aim. Studying of possible patterns of Docetaxel-related impurities formation between intact and gamma-irradiated batches.Materials and methods. Objects of study – lyophilizates of Docetaxel polymeric forms was previously obtained by the authors. Qualitative and quantitative analysis was performed by high pressure liquid chromatography.Results and discussion. Docetaxel-related impurities was determined and evaluated in the intact and gamma-treated batches. It was cleared, that related substances in the gamma-treated batches was different in comparison with non-treated but after vary storage periods.Conclusion. Docetaxel-loaded polymeric drugs shown proper stability during long term storage. The influence of gamma-treatment to Docetaxelrelated impurities content was found. Gamma sterilization can be promising method for novel drugs, but it needs individual study in the each case.
Linking organizational culture with financial performance
Authors: Abu Mahfouz Muhannad , Muhumed Daud Ahmed 
Published: February 2020

Organizational culture and firm performance are some of the most researched topics in management because of their importance to organizations. Many studies have explored the relationship between organizational culture and firm performance. The aim of the study is to link organizational culture and firm financial performance and this link was explained by conducting a literature review. The paper investigated the linking organizational culture and financial performance and found that there are different types of organizational cultures and all of them affect the performance of organizations.
Physical exploration of a virtual reality environment: Effects on spatiotemporal associative recognition of episodic memory
Authors: van Helvoort Daniël , Stobbe Emil , Benning Richard , Otgaar Henry , van de Ven Vincent 
Published: February 2020

AbstractAssociative memory has been increasingly investigated in immersive virtual reality (VR) environments, but conditions that enable physical exploration remain heavily under-investigated. To address this issue, we designed two museum rooms in VR throughout which participants could physically walk (i.e., high immersive and interactive fidelity). Participants were instructed to memorize all room details, which each contained nine paintings and two stone sculptures. On a subsequent old/new recognition task, we examined to what extent shared associated context (i.e., spatial boundaries, ordinal proximity) and physically travelled distance between paintings facilitated recognition of paintings from the museum rooms. Participants more often correctly recognized a sequentially probed old painting when the directly preceding painting was encoded within the same room or in a proximal position, relative to those encoded across rooms or in a distal position. A novel finding was that sequentially probed paintings from the same room were also recognized better when the physically travelled spatial or temporal distance between the probed paintings was shorter, as compared with longer distances. Taken together, our results in highly immersive VR support the notion that spatiotemporal context facilitates recognition of associated event content.
ANALISIS PENYERAPAN TENAGA KERJA SEKTORAL DI KABUPATEN SUMBAWA BARAT TAHUN 2008-2012
Authors: Suwardi Didi 
Published: February 2020

Penelitian ini bertujuan untuk: (1) Mengetahui pengaruh pertumbuhan jumlah penduduk dan pertumbuhan Produk Domestik Regional Bruto (PDRB) masing-masing sektor terhadap penyerapan tenaga kerja sektoral di Kabupaten Sumbawa Barat; (2) Mengetahui hubungan pertumbuhan jumlah penduduk dan pertumbuhan PDRB masing-masing sektor terhadap penyerapan tenaga kerja sektoral di Kabupaten Sumbawa Barat; (3) Mengetahui kemampuan masing-masing sektor ekonomi dalam menyerap tenaga kerja di Kabupaten Sumbawa Barat. Analisis data dilakukan dengan menggunakan Regresi Linier Berganda. Hasil penelitian menununjukkan bahwa: (1) pertumbuhan jumlah penduduk tidak berpengaruh signifikan terhadap penyerapan tenaga kerja pada semua sektor, adapun pertumbuhan PDRB sektor pertanian, pertambangan, perdagangan dan jasa juga tidak berpengaruh signifikan, hanya pertumbuhan PDRB pada sektor industri yang berpengaruh signifikan terhadap penyerapan tenaga kerja; (2) Pertumbuhan jumlah penduduk memiliki hubungan yang positif terhadap penyerapan tenaga kerja pada sektor pertanian, perdagangan, dan jasa-jasa, sementara sektor pertambangan dan industri memiliki hubungan yang negatif. Terdapat hubungan positif antara pertumbuhan PDRB dengan penyerapan tenaga kerja pada sektor pertanian, industri, perdagangan dan jasa-jasa; (3) Kemampuan dari sektor pertanian, sektor pertambangan, sektor industri, sektor perdagangan dan sektor jasa-jasa dalam menyerap tenaga kerja berturut-turut adalah sebagi berikut 16.041 jiwa, 4.226 jiwa, 4.351 jiwa, 24.327 jiwa, dan 48.890 jiwa.
Kata kunci : Pertumbuhan PDRB, Pertumbuhan penduduk ,Tenaga kerja sektoral
GMP manufacture of Regulatory T cells (Tregs) to facilitated reduced reliance on immunosuppressive drugs following renal transplantation
Authors: Wahab Seetha Abdul , Et al.  
Published: February 2020

Seetha Abdul Wahab, Matthew Brook, Giovanna Lombardi, Joanna Hester, Paul Harden, Fadi Issa
Due to significant side effects, it is desirable to be able to reduce patient’s dependency on immunosuppressive drugs after organ transplantation. Personalised Treg therapy offers a promising route to facilitating a reduction in immunosuppression. The TWO Study employs a GMP-compliant manufacturing process to produce autologous Tregs for therapy. GMP is a quality management system that entails production and quality control of advanced therapy medicinal products (ATMPs) ensuring that ATMPs are consistently produced per clinical trial authorisation or product specification. This work is undertaken at a purpose-built GMP facility at Guy’s Hospital, London. Patient samples of peripheral blood are received from Oxford and then volume reduced aseptically to 40 mls using Sepax. CD8+cells are eliminated using CliniMACS CD8 reagent. CliniMACS CD25 reagent is then added to isolate CD25+ cells. Isolated cells are expanded using Expact Treg bead suspension kit and Rapamycin. Cells are fed every two days and subsequently re-stimulated twice at five feeding cycle intervals or until the required cell number is reached. The cells are then pooled and centrifuged at 1000xg. The resulting pellet is re-suspended and the Expact expansion beads removed using CliniMACS tubing set LS. Finally, the cell product is formulated in CryoStor CS-10 to a maximum dose concentration of 10x106 cells/kg patient body weight. At the same time, a back-up dose is prepared as well as reference and QC samples. These are all cooled to -80oC at c.1oC/min and stored in liquid nitrogen vapour phase until dispatch. As of end 2019, three patient samples have been processed. Tregs were purified and propagated to 194.4, 282.1, and 183.4-fold expansion yielding 3.5x109, 2.2x109, and 3.1x109 cells respectively. Samples 1 and 2 have been released for treatment after phenotyping and testing for suppression activity, sterility, and contamination with aerobic/anaerobic pathogens and mycoplasma. The third product is scheduled to be released for treatment in May 2020.
Global Chemistry and Thermal Structure Models for the Hot Jupiter WASP-43b and Predictions for JWST
Authors: Venot Olivia , Parmentier Vivien , Blecic Jasmina , Cubillos Patricio E. , Waldmann Ingo P. , Changeat Quentin , Moses Julianne I. , Tremblin Pascal , Crouzet Nicolas , Gao Peter , Powell Diana , Lagage Pierre-Olivier , Dobbs-Dixon Ian , Steinrueck Maria E. , Kreidberg Laura , Batalha Natalie , Bean Jacob L. , Stevenson Kevin B. , Casewell Sarah , Carone Ludmila 
Published: February 2020

Abstract
The James Webb Space Telescope (JWST) is expected to revolutionize the field of exoplanets. The broad wavelength coverage and the high sensitivity of its instruments will allow characterization of exoplanetary atmospheres with unprecedented precision. Following the Call for the Cycle 1 Early Release Science Program, the Transiting Exoplanet Community was awarded time to observe several targets, including WASP-43b. The atmosphere of this hot Jupiter has been intensively observed but still harbors some mysteries, especially concerning the day–night temperature gradient, the efficiency of the atmospheric circulation, and the presence of nightside clouds. We will constrain these properties by observing a full orbit of the planet and extracting its spectroscopic phase curve in the 5–12 μm range with JWST/MIRI. To prepare for these observations, we performed extensive modeling work with various codes: radiative transfer, chemical kinetics, cloud microphysics, global circulation models, JWST simulators, and spectral retrieval. Our JWST simulations show that we should achieve a precision of 210 ppm per 0.1 μm spectral bin on average, which will allow us to measure the variations of the spectrum in longitude and measure the nightside emission spectrum for the first time. If the atmosphere of WASP-43b is clear, our observations will permit us to determine if its atmosphere has an equilibrium or disequilibrium chemical composition, eventually providing the first conclusive evidence of chemical quenching in a hot Jupiter atmosphere. If the atmosphere is cloudy, a careful retrieval analysis will allow us to identify the cloud composition.
Assessment of Systematic Uncertainties in the Cosmological Analysis of the SDSS Supernovae Photometric Sample
Authors: Popovic Brodie , Scolnic Dan , Kessler Richard 
Published: February 2020

Abstract
Improvements to the precision of measurements of cosmological parameters with Type Ia supernovae (SNe Ia) are expected to come from large photometrically identified (photometric) supernova (SN) samples. Here we reanalyze the Sloan Digital Sky Survey (SDSS) photometric SN sample, with roughly 700 high-quality, likely but unconfirmed SNe Ia light curves, to develop new analysis tools aimed at evaluating systematic uncertainties on the dark energy equation-of-state parameter w. Since we require a spectroscopically measured host-galaxy redshift for each SN, we determine the associated selection efficiency of host galaxies in order to simulate bias corrections. We determine that the misassociation rate of host galaxies is 0.6%; ignoring this effect in simulated bias corrections leads to a w-bias of Δw = +0.0007, where w is evaluated from SNe Ia and priors from measurements of baryon acoustic oscillations and the cosmic microwave background. We assess the uncertainty in our modeling of the host-galaxy selection efficiency and find the associated w uncertainty to be −0.0072. Finally, we explore new core-collapse (CC) models in simulated training samples and find that adjusting the CC luminosity distribution to be in agreement with previous Pan-STARRS analyses yields a better match to the SDSS data. The impact of ignoring this adjustment is Δw = −0.0109; the impact of replacing the new CC models with those used by Pan-STARRS is Δw = −0.0028. These systematic uncertainties are subdominant to the statistical constraints from the SDSS sample, but must be considered in future photometric analyses of large SN samples such as those from the Dark Energy Survey (DES), the Large Synoptic Survey Telescope (LSST), and the Wide Field Infrared Survey Telescope (WFIRST).
The Redshift and Star Formation Mode of AzTEC2: A Pair of Massive Galaxies at z = 4.63
Authors: Jiménez-Andrade E. F. , Zavala J. A. , Magnelli B. , Casey C. M. , Liu D. , Romano-Díaz E. , Schinnerer E. , Harrington K. , Aretxaga I. , Karim A. , Staguhn J. , Burnham A. D. , Montaña A. , Smolčić V. , Yun M. , Bertoldi F. , Hughes D. 
Published: February 2020

Abstract
We combine observations from the Atacama Large Millimeter/submillimeter Array and the NOrthern Extended Millimeter Array to assess the redshift and to study the star formation conditions in AzTEC2, one of the brightest submillimeter galaxies (SMGs) in the COSMOS field (

mJy). Our high-resolution observations confirm that AzTEC2 splits into two components (namely AzTEC2-A and AzTEC2-B) for which we detect [C ii] and 12CO(5 → 4) line emission, implying a redshift of 4.626 ± 0.001 (4.633 ± 0.001) for AzTEC2-A (AzTEC2-B) and ruling out previous associations with a galaxy at

. We use the 12CO(5 → 4) line emission and adopt typical SMG-like gas excitation conditions to estimate the molecular gas mass, which is

for AzTEC2-A, and a factor four lower for AzTEC2-B. With the infrared-derived star formation rate of AzTEC2-A (

yr−1) and AzTEC2-B (

yr−1), they both will consume their current gas reservoir within (30–200) Myr. We find evidence of a rotation-dominated [C ii] disk in AzTEC2-A, with a deprojected rotational velocity of

km s−1, velocity dispersion

km s−1, and dynamical mass of

. We propose that an elevated gas accretion rate from the cosmic web might be the main driver of the intense levels of star formation in AzTEC2-A, which might be further enhanced by gravitational torques induced by its minor companion (AzTEC2-B). These results strengthen the picture whereby the population of single-dish selected SMGs is rather heterogeneous, including a population of pairs of massive, highly active galaxies in a pre-coalescence phase.
The Fifth Candidate for an Intermediate-mass Black Hole in the Galactic Center
Authors: Takekawa Shunya , Oka Tomoharu , Iwata Yuhei , Tsujimoto Shiho , Nomura Mariko 
Published: February 2020

Abstract
We report the results of high-resolution molecular line observations of the high-velocity compact cloud HCN–0.085–0.094 with the Atacama Large Millimeter/submillimeter Array. The HCN J = 4–3, HCO+
J = 4–3, and CS J = 7–6 line images reveal that HCN–0.085–0.094 consists mainly of three small clumps with extremely broad velocity widths. Each of the three clumps has a 5.5 GHz radio continuum counterpart in its periphery toward Sgr A*. The positional relationship indicates that their surfaces have been ionized by ultraviolet photons from young stars in the central cluster, suggesting the clumps are in close proximity to the Galactic nucleus. One of the three clumps has a ring-like structure with a very steep velocity gradient. This kinematical structure suggests an orbit around a point-like object with a mass of ∼104
M
⊙. The absence of stellar counterparts indicates that the point-like object may be a quiescent black hole. This discovery adds another intermediate-mass black hole candidate in the central region of our Galaxy.
Nine New Repeating Fast Radio Burst Sources from CHIME/FRB
Authors: Fonseca E. , Andersen B. C. , Bhardwaj M. , Chawla P. , Good D. C. , Josephy A. , Kaspi V. M. , Masui K. W. , Mckinven R. , Michilli D. , Pleunis Z. , Shin K. , Tendulkar S. P. , Bandura K. M. , Boyle P. J. , Brar C. , Cassanelli T. , Cubranic D. , Dobbs M. , Dong F. Q. , Gaensler B. M. , Hinshaw G. , Landecker T. L. , Leung C. , Li D. Z. , Lin H.-H. , Mena-Parra J. , Merryfield M. , Naidu A. , Ng C. , Patel C. , Pen U. , Rafiei-Ravandi M. , Rahman M. , Ransom S. M. , Scholz P. , Smith K. M. , Stairs I. H. , Vanderlinde K. , Yadav P. , Zwaniga A. V. 
Published: February 2020

Abstract
We report on the discovery and analysis of bursts from nine new repeating fast radio burst (FRB) sources found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. These sources span a dispersion measure (DM) range of 195–1380 pc cm−3. We detect two bursts from three of the new sources, three bursts from four of the new sources, four bursts from one new source, and five bursts from one new source. We determine sky coordinates of all sources with uncertainties of ∼10′. We detect Faraday rotation measures (RMs) for two sources, with values −20(1) and −499.8(7) rad m−2, that are substantially lower than the RM derived from bursts emitted by FRB 121102. We find that the DM distribution of our events, combined with the nine other repeaters discovered by CHIME/FRB, is indistinguishable from that of thus far non-repeating CHIME/FRB events. However, as previously reported, the burst widths appear statistically significantly larger than the thus far non-repeating CHIME/FRB events, further supporting the notion of inherently different emission mechanisms and/or local environments. These results are consistent with previous work, though are now derived from 18 repeating sources discovered by CHIME/FRB during its first year of operation. We identify candidate galaxies that may contain FRB 190303.J1353+48 (DM = 222.4 pc cm−3).