bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mothers’ and Fathers’ Perspectives on the Causes of Their Child’s Disorder
Authors: Felnhofer Anna , Bussek Theresa , Goreis Andreas , Kafka Johanna X , König Dorothea , Klier Claudia , Zesch Heidi , Kothgassner Oswald D 
Published: July 2020

AbstractBackgroundParental beliefs about the cause of their child’s illness are thought to affect parents’ help-seeking behaviors, treatment decisions, and the child’s health outcomes. Yet, research on parental beliefs about disease causation is still scarce. While a small number of studies assesses parental cause attributions for singular disorders (e.g., neurodevelopmental disorders), no study has compared disorders with differing physical versus mental conditions or with mixed comorbidities in children and adolescents or their caregivers. Furthermore, most pediatric research suffers from a lack of data on fathers.ObjectiveHence, the objective of the current study was to test for possible differences in mothers’ and fathers’ perceptions about the etiology of their child’s illness.MethodsForty-two parent couples (overall N = 84) whose child had been diagnosed either with Attention Deficit Hyperactivity-Disorder (ADHD) or Autism Spectrum Disorder (ASD) (category “neurodevelopmental disorder”) or with a primary physical illness and a comorbid mental disorder, e.g. depression (category “psychosomatic disorder”) were asked to rate possible causes of their child’s illness using a modified version of the revised Illness Perception Questionnaire (IPQ) Cause scale.ResultsA two-way ANOVA showed that psychosomatic disorders were significantly more strongly attributed to be caused by medical and environmental stressors than neurodevelopmental disorders. A significant parent × illness category interaction revealed that this effect was more pronounced in fathers.ConclusionsBy providing first insights into parental beliefs about the etiology of their children’s neurodevelopmental versus psychosomatic disorders, this study paves ground for future research and tailored counseling of affected families.
Intrathoracic sleeve gastrectomy migration with gastric volvulus treated with laparoscopic repair and conversion to gastric bypass
Authors: Alwatari Yahya , Roriz-Silva Renato , Bolckmans Roel , Campos Guilherme M 
Published: July 2020

Abstract
A 43 years old female with laparoscopic sleeve gastrectomy (SG) and an ‘anterior’ hiatal hernia repair 11 years ago, presented with 3 years history dysphagia and heartburn. Upper gastrointestinal barium showed an almost complete intrathoracic migration of the SG with a partial organoaxial volvulus. Upper endoscopy revealed a 10 cm hiatal hernia with grade B esophagitis. Laparoscopic revision surgery with reduction of the gastric sleeve, standard posterior hiatal hernia repair, resection of the narrowed remnant of the SG and conversion to a gastric bypass was performed. No postoperative complications occurred. The patient is asymptomatic at 2 years of follow-up. We present the technical standards for the management and discuss the suspected pathophysiology of this rare but challenging condition.
Patterns of illness and injury on Antarctic research cruises, 2004–2019: a descriptive analysis
Authors: Visser Jenny T 
Published: July 2020

Abstract

Background
Before the impact of the coronavirus disease 2019 pandemic, cruise travel had experienced exponential growth in the preceding decade. Travel medicine practitioners were increasingly called upon to provide pre-cruise travel advice and medical clearance. Demand for these services will return at some time in the future.

Methods
The clinical conditions seen in those presenting for care on six small-vessel scientific cruises to Antarctica were analysed.

Results
Personnel presented on 196 occasions resulting in 257 consultations (when initial plus all follow-up consultations were included). Personnel presented with a clinical condition at a rate of 17.9 per 1000 person-days at sea. The total consultation rate was 23.5 per 1000 person-days at sea. Injury accounted for 24% of all presentations at a rate of 4.3 per 1000 person-days at sea. Dermatological, soft tissue and musculoskeletal, general malaise and motion sickness were the four most common presentations.

Conclusions
Pre-cruise advice for travellers planning small-vessel cruises to polar regions needs to include skin care, prevention and management of sea sickness and how to reduce the risk of injury. Those providing medical care on such cruises should be prepared to manage a wide range of clinical presentations.
Rational coordination with no communication or conventions
Authors: Goranko Valentin , Kuusisto Antti , Rönnholm Raine 
Published: July 2020

AbstractWe study pure coordination games where in every outcome, all players have identical payoffs, ‘win’ or ‘lose’. We identify and discuss a range of ‘purely rational principles’ guiding the reasoning of rational players in such games and compare the classes of coordination games that can be solved by such players with no preplay communication or conventions. We observe that it is highly nontrivial to delineate a boundary between purely rational principles and other decision methods, such as conventions, for solving such coordination games.
The Patterns and Associated Cost of Serologic Testing for Helicobacter pylori in the U.S. Military Health System
Authors: Pak Kevin , Junga Zachary , Mertz Andrew , Singla Manish 
Published: July 2020

Abstract

Introduction
Helicobacter pylori (H. pylori) infection affects about half of the world’s population and can lead to multiple complications if left untreated. Testing for H. pylori infection in appropriate patients with prompt treatment followed by the testing of eradication is the standard of care in the United States. Active Duty Service members (ADSMs) in the U.S. military are a unique patient population that may be at higher risk for acquiring H. pylori infection given frequent deployments to developing countries. Noninvasive diagnostic strategies include the urea breath test, the stool antigen test, and serologic testing, which include H. pylori immunoglobulin M (IgM), immunoglobulin A (IgA), and immunoglobulin G (IgG) antibodies. Among noninvasive methods, the least sensitive is serology, and although there is clinical utility in testing for H. pylori IgG antibodies, H. pylori IgA or IgM antibodies have limited clinical utility. Despite this, H. pylori IgA and IgM antibodies are still widely ordered across the Military Health System.

Materials and Methods
In order to determine how frequently this testing is being ordered and the associated cost, we conducted a retrospective cross-sectional study of H. pylori serologic testing utilization in the MHS from October 2015 to September 2018 in adult patients using the MHS Data Repository. All H. pylori IgM, IgA, and IgG antibodies, H. pylori stool antigen tests, and H. pylori urea breath tests were queried during this time period across all ADSMs, retirees, and ADSM dependents for all adults. Cost information was obtained from LabCorp, and the institutional price used for cost analysis was the same throughout all military treatment facilities in the Department of Defense (DOD).

Results
We discovered that over a 3-yr period, 1,916 H. pylori IgA and 2,492 IgM antibodies were ordered. In total, the DOD spent close to $400,000 on antibody-based testing for H. pylori not accounting for indirect associated costs like personnel, supplies, repeat testing, as well as the costs of delayed diagnosis and associated complications.

Conclusion
H. pylori IgM and IgA have limited clinical utility, are inaccurate, and are costly to maintain, especially when more accurate alternative tests are available. Based on our analysis, we strongly recommend the removal of the H. pylori IgA and IgM serologic tests throughout the DOD in order to improve the efficiency and quality of care for patients suspected of having an H. pylori infection. Further research is needed to determine how these tests are ordered, how providers are responding to the results of the serologic tests, and if noninvasive testing is being ordered appropriately.
AT2018kzr: the merger of an oxygen–neon white dwarf and a neutron star or black hole
Authors: Gillanders J H , Sim S A , Smartt S J 
Published: July 2020

ABSTRACT
We present detailed spectroscopic analysis of the extraordinarily fast-evolving transient AT2018kzr. The transient’s observed light curve showed a rapid decline rate, comparable to the kilonova AT2017gfo. We calculate a self-consistent sequence of radiative transfer models (using tardis) and determine that the ejecta material is dominated by intermediate-mass elements (O, Mg, and Si), with a photospheric velocity of ∼12 000–14 500 $\rm {km}\, s^{-1}$. The early spectra have the unusual combination of being blue but dominated by strong Fe ii and Fe iii absorption features. We show that this combination is only possible with a high Fe content (3.5 per cent). This implies a high Fe/(Ni+Co) ratio. Given the short time from the transient’s proposed explosion epoch, the Fe cannot be 56Fe resulting from the decay of radioactive 56Ni synthesized in the explosion. Instead, we propose that this is stable 54Fe, and that the transient is unusually rich in this isotope. We further identify an additional, high-velocity component of ejecta material at ∼20 000–26 000 $\rm {km}\, s^{-1}$, which is mildly asymmetric and detectable through the Ca ii near-infrared triplet. We discuss our findings with reference to a range of plausible progenitor systems and compare with published theoretical work. We conclude that AT2018kzr is most likely the result of a merger between an ONe white dwarf and a neutron star or black hole. As such, it would be the second plausible candidate with a good spectral sequence for the electromagnetic counterpart of a compact binary merger, after AT2017gfo.
On using dipolar modes to constrain the helium glitch in red giant stars
Authors: Dréau G , Cunha M S , Vrard M , Avelino P P 
Published: July 2020

ABSTRACT
The space-borne missions CoRoT and Kepler have revealed numerous mixed modes in red giant stars. These modes carry a wealth of information about red giant cores, but are of limited use when constraining rapid structural variations in their envelopes. This limitation can be circumvented if we have access to the frequencies of the pure acoustic dipolar modes in red giants, i.e. the dipole modes that would exist in the absence of coupling between gravity and acoustic waves. We present a pilot study aimed at evaluating the implications of using these pure acoustic mode frequencies in seismic studies of the helium structural variation in red giants. The study is based on artificial seismic data for a red giant branch stellar model, bracketing seven acoustic dipole radial orders around νmax. The pure acoustic dipole-mode frequencies are derived from a fit to the mixed-mode period spacings and then used to compute the pure acoustic dipole-mode second differences. The pure acoustic dipole-mode second differences inferred through this procedure follow the same oscillatory function as the radial-mode second differences. The additional constraints brought by the dipolar modes allow us to adopt a more complete description of the glitch signature when performing the fit to the second differences. The amplitude of the glitch retrieved from this fit is 15${{\ \rm per\ cent}}$ smaller than that from the fit based on the radial modes alone. Also, we find that thanks to the additional constraints, a bias in the inferred glitch location, found when adopting the simpler description of the glitch, is avoided.
3D structure of the H ii region Sh2-235 from tunable-filter optical observations
Authors: Kirsanova M S , Boley P A , Moiseev A V , Wiebe D S , Uklein R I 
Published: July 2020

ABSTRACT
We present observations of the H α, H β, [S ii] λλ6716, 6731 and [N ii] λ6583 emission lines in the galactic H ii region Sh2-235 with the Mapper of Narrow Galaxy Lines (MaNGaL), a tunable filter at the 1-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences. We show that the H ii region is obscured by neutral material with AV ≈ 2−4 mag. The area with the highest AV is situated to the south-west from the ionizing star and coincides with a maximum detected electron density of ≳300 cm−3. The combination of these results with archive AKARI far-infrared data allows us to estimate the contribution of the front and rear walls to the total column density of neutral material in S235 and explain the 3D structure of the region. The H ii region consist of a denser, more compact portion deeply embedded in the neutral medium and the less dense and obscured gas. The front and rear walls of the H ii region are inhomogeneous, with the material in the rear wall having a higher column density. We find a two-sided photodissociation region in the dense clump S235 East 1, illuminated by a UV field with G0 = 50−70 and 200 Habing units in the western and eastern parts, respectively.
Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents
Authors: Moretti Charlotte , Blanco Mélina , Ialy-Radio Côme , Serrentino Maria-Elisabetta , Gobé Clara , Friedman Robin , Battail Christophe , Leduc Marjorie , Ward Monika A , Vaiman Daniel , Tores Frederic , Cocquet Julie 
Published: July 2020

AbstractTransmission distorters (TDs) are genetic elements that favor their own transmission to the detriments of others. Slx/Slxl1 (Sycp3-like-X-linked and Slx-like1) and Sly (Sycp3-like-Y-linked) are TDs, which have been coamplified on the X and Y chromosomes of Mus species. They are involved in an intragenomic conflict in which each favors its own transmission, resulting in sex ratio distortion of the progeny when Slx/Slxl1 versus Sly copy number is unbalanced. They are specifically expressed in male postmeiotic gametes (spermatids) and have opposite effects on gene expression: Sly knockdown leads to the upregulation of hundreds of spermatid-expressed genes, whereas Slx/Slxl1-deficiency downregulates them. When both Slx/Slxl1 and Sly are knocked down, sex ratio distortion and gene deregulation are corrected. Slx/Slxl1 and Sly are, therefore, in competition but the molecular mechanism remains unknown. By comparing their chromatin-binding profiles and protein partners, we show that SLX/SLXL1 and SLY proteins compete for interaction with H3K4me3-reader SSTY1 (Spermiogenesis-specific-transcript-on-the-Y1) at the promoter of thousands of genes to drive their expression, and that the opposite effect they have on gene expression is mediated by different abilities to recruit SMRT/N-Cor transcriptional complex. Their target genes are predominantly spermatid-specific multicopy genes encoded by the sex chromosomes and the autosomal Speer/Takusan. Many of them have coamplified with not only Slx/Slxl1/Sly but also Ssty during muroid rodent evolution. Overall, we identify Ssty as a key element of the X versus Y intragenomic conflict, which may have influenced gene content and hybrid sterility beyond Mus lineage since Ssty amplification on the Y predated that of Slx/Slxl1/Sly.
Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts
Authors: Yang Min , Tao Xin , Titus Shiny , Zhao Tianhua , Scott Richard T , Seli Emre 
Published: July 2020

Abstract
Early embryonic development is characterized by drastic changes in chromatin structure that affects the accessibility of the chromatin. In human, the chromosome reorganization and its involvement in the first linage segregation are poorly characterized due to the difficulties in obtaining human embryonic material and limitation on low input technologies. In this study, we aimed to explore the chromatin remodeling pattern in human preimplantation embryos and gain insight into the epigenetic regulation of inner cell mass (ICM) and trophectoderm (TE) differentiation. We optimized ATAC-seq (an assay for transposase-accessible chromatin using sequencing) to analyze the chromatin accessibility landscape for low DNA input. Sixteen preimplantation human blastocysts frozen on Day 6 were used. Our data showed that ATAC peak distributions of the promoter regions (&lt;1 kb) and distal regions versus other regions were significantly different between ICM versus TE samples (P &lt; 0.01). We detected that a higher percentage of accessible binding loci were located within 1 kb of the transcription start site in ICM compared to TE (P &lt; 0.01). However, a higher percentage of accessible regions was detected in the distal region of TE compared to ICM (P &lt; 0.01). In addition, eight differential peaks with a false discovery rate &lt;0.05 between ICM and TE were detected. This is the first study to compare the landscape of the accessible chromatin between ICM and TE of human preimplantation embryos, which unveiled chromatin-level epigenetic regulation of cell lineage specification in early embryo development.
Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces
Authors: Tian Jinzhong , Yang Gaohua , Gu Yang , Sun Xinqiang , Lu Yinhua , Jiang Weihong 
Published: July 2020

Abstract
Quorum-sensing (QS) mediated dynamic regulation has emerged as an effective strategy for optimizing product titers in microbes. However, these QS-based circuits are often created on heterologous systems and require careful tuning via a tedious testing/optimization process. This hampers their application in industrial microbes. Here, we design a novel QS circuit by directly integrating an endogenous QS system with CRISPRi (named EQCi) in the industrial rapamycin-producing strain Streptomyces rapamycinicus. EQCi combines the advantages of both the QS system and CRISPRi to enable tunable, autonomous, and dynamic regulation of multiple targets simultaneously. Using EQCi, we separately downregulate three key nodes in essential pathways to divert metabolic flux towards rapamycin biosynthesis and significantly increase its titers. Further application of EQCi to simultaneously regulate these three key nodes with fine-tuned repression strength boosts the rapamycin titer by ∼660%, achieving the highest reported titer (1836 ± 191 mg/l). Notably, compared to static engineering strategies, which result in growth arrest and suboptimal rapamycin titers, EQCi-based regulation substantially promotes rapamycin titers without affecting cell growth, indicating that it can achieve a trade-off between essential pathways and product synthesis. Collectively, this study provides a convenient and effective strategy for strain improvement and shows potential for application in other industrial microorganisms.
Ependymoma and Chordoma
Authors: Levine Adrian B , Wong Derek , Fatehi Mostafa , Yip Stephen 
Published: July 2020

Abstract
Ependymoma and chordoma are 2 tumors that occur throughout the craniospinal axis, and for which the extent of neurosurgical resection has a key prognostic role. Both tumors have distinctive pathologic features, yet can present significant diagnostic challenges to pathologists in cases without classical histology. The molecular understanding of ependymoma has had significant advances in the past decade, with the identification of 9 molecular groups with significant prognostic and clinical implications, while a comprehensive study of chordoma further emphasized the key role of brachyury overexpression in its pathogenesis. In this review, we discuss the pathogenesis, radiology and gross pathology, histology, and molecular features of these 2 tumors, as well as active research into targeted therapies, with an emphasis on practical diagnostic challenges, and the use of immunohistochemical and molecular tests in routine diagnostic practice.
Occupational low-dose irradiation and cancer risk among medical radiation workers
Authors: Chartier H , Fassier P , Leuraud K , Jacob S , Baudin C , Laurier D , Bernier M-O 
Published: July 2020

Abstract

Background
Medical workers are the largest group of workers occupationally exposed to low doses of ionizing radiation (IR) worldwide.

Aims
This review presents all the cohorts of medical workers exposed in the world and summarizes cancer risks associated with radiation exposure in this population.

Methods
Epidemiological studies on health professionals exposed to IR published from 1975 to 2019 were reviewed. Strength of evidence was assessed according to the modified Royal College of General Practitioners three-star system.

Results
Among the 16 epidemiological studies focusing on cancers from 11 cohorts among medical staff exposed to radiation, higher risks of cancer were observed for pre-1950 exposure and for medical workers who performed fluoroscopically guided interventional procedures or radionuclides procedures compared to those who did not. However, strength of evidence supporting the associations remains moderate as several methodological limits including the lack of dosimetry data, lifestyle factors and recent updates may obscure the link between medical occupational exposure and cancer occurrence.

Conclusions
Excess risk of cancer is suspected for high and former exposures. The more highly exposed professions, i.e. interventional physicians and nuclear medicine workers, should be monitored carefully. Collaborative projects aiming to increase the quantity and quality of information of the studied populations would be a key point