bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preterm birth and risk of type 1 and type 2 diabetes: a national cohort study
Authors: Crump Casey , Sundquist Jan , Sundquist Kristina 
Published: December 2019

Abstract
Aims/hypothesis
Preterm birth (gestational age <37 weeks) has been associated with insulin resistance early in life. However, no large population-based studies have examined risks of type 1 and type 2 diabetes and potential sex-specific differences from childhood into adulthood. Clinicians will increasingly encounter adults who were born prematurely and will need to understand their long-term risks. We hypothesised that preterm birth is associated with increased risks of type 1 and type 2 diabetes into adulthood.

Methods
A national cohort study was conducted of all 4,193,069 singletons born in Sweden during 1973–2014, who were followed up for type 1 and type 2 diabetes identified from nationwide diagnoses and pharmacy data to the end of 2015 (maximum age 43 years; median age at the end of follow-up 22.5 years). Cox regression was used to adjust for potential confounders, and co-sibling analyses assessed the influence of shared familial (genetic and/or environmental) factors.

Results
In 92.3 million person-years of follow-up, 27,512 (0.7%) and 5525 (0.1%) people were identified with type 1 and type 2 diabetes, respectively. Gestational age at birth was inversely associated with both type 1 and type 2 diabetes risk. Adjusted HRs for type 1 and type 2 diabetes at age <18 years associated with preterm birth were 1.21 (95% CI, 1.14, 1.28) and 1.26 (95% CI, 1.01, 1.58), respectively, and at age 18–43 years were 1.24 (95% CI, 1.13, 1.37) and 1.49 (95% CI, 1.31, 1.68), respectively, compared with full-term birth. The associations between preterm birth and type 2 (but not type 1) diabetes were stronger among females (e.g. at age 18–43 years, females: adjusted HR, 1.75; 95% CI, 1.47, 2.09; males: 1.28; 95% CI, 1.08, 1.53; p < 0.01 for additive and multiplicative interaction). These associations were only partially explained by shared genetic or environmental factors in families.

Conclusions/interpretation
In this large national cohort, preterm birth was associated with increased risk of type 1 and type 2 diabetes from childhood into early to mid-adulthood. Preterm-born children and adults may need early preventive evaluation and long-term monitoring for diabetes.
Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models
Authors: Zhang Rui , Yuan Fengjiao , Shu Yang , Tian Yaomei , Zhou Bailing , Yi Linglu , Zhang Xueyan , Ding Zhenyu , Xu Heng , Yang Li 
Published: December 2019

AbstractDevelopment of personalized cancer vaccines based on neoantigens has become a new direction in cancer immunotherapy. Two forms of cancer vaccines have been widely studied: tumor-associated antigen (including proteins, peptides, or tumor lysates)-pulsed dendritic cell (DC) vaccines and protein- or peptide-adjuvant vaccines. However, different immune modalities may produce different therapeutic effects and immune responses when the same antigen is used. Therefore, it is necessary to choose a more effective neoantigen vaccination method. In this study, we compared the differences in immune and anti-tumor effects between neoantigen-pulsed DC vaccines and neoantigen-adjuvant vaccines using murine lung carcinoma (LL2) candidate neoantigens. The enzyme-linked immunospot (ELISPOT) assay showed that 4/6 of the neoantigen-adjuvant vaccines and 6/6 of the neoantigen-pulsed DC vaccines induced strong T-cell immune responses. Also, 2/6 of the neoantigen-adjuvant vaccines and 5/6 of the neoantigen-pulsed DC vaccines exhibited potent anti-tumor effects. The results indicated that the neoantigen-pulsed DC vaccines were superior to the neoantigen-adjuvant vaccines in both activating immune responses and inhibiting tumor growth. Our fundings provide an experimental basis for the selection of immune modalities for the use of neoantigens in individualized tumor immunotherapies.
Stellenwert der Testung der Tumormutationslast
Authors: Wild Peter J. 
Published: December 2019

ZusammenfassungDie seit kurzem verfügbare Therapie mit Immun-Checkpoint-Inhibitoren (ICI) für Patienten mit nichtkleinzelligem Lungenkarzinom (NSCLC) bietet zwar einen Überlebensvorteil im Vergleich zur Chemotherapie, die Gesamtansprechrate beträgt aber nur etwa 20 %. Um Patienten zu identifizieren, die von einer ICI-Therapie profitieren, werden Biomarker zunehmend wichtiger. Die PD-L1-Expression war der erste entwickelte prädiktive Biomarker, konnte jedoch die Wirksamkeit von ICI nicht ausreichend vorhersagen. Ein weiterer Biomarker, die Tumormutationslast (TMB), ist definiert als die Anzahl der Mutationen pro Megabase analysierte DNA. Auch die Mikrosatelliteninstabilität (MSI) fungiert als prädiktiver Marker für ein Ansprechen auf ICI-Therapie. Viele Tumorentitäten weisen eine hohe Korrelation von MSI und hoher TMB auf. Studien zeigten für Patienten mit NSCLC und einer TMB von mindestens 10 Mutationen pro Megabase einen Vorteil für das progressionsfreie Überleben.
A techno-economic model-based analysis of the renewable energy transition in the Indian subcontinent region
Authors: Bhat Karthik Subramanya , Bachhiesl Udo , Feichtinger Gerald , Stigler Heinz 
Published: December 2019

AbstractIndia, as a ‘developing’ country, is in the middle of a unique situation of handling its energy transition towards carbon-free energy along with its continuous economic development. With respect to the agreed COP 21 and SDG 2030 targets, India has drafted several energy strategies revolving around clean renewable energy. With multiple roadblocks for development of large hydro power capacities within the country, the long-term renewable goals of India focus highly on renewable energy technologies like solar Photo-Voltaic (PV) and wind capacities. However, with a much slower rate of development in transmission infrastructure and the given situations of the regional energy systems in the Indian subcontinent, these significant changes in India could result in severe technical and economic consequences for the complete interconnected region. The presented investigations in this paper have been conducted using ATLANTIS_India, a unique techno-economic simulation model developed at the Institute of Electricity Economics and Energy Innovation/Graz University of Technology, designed for the electricity system in the Indian subcontinent region. The model covers the electricity systems of India, Bangladesh, Bhutan, Nepal, and Sri Lanka, and is used to analyse a scenario where around 118 GW of solar PV and wind capacity expansion is planned in India until the target year 2050. This paper presents the simulation approach as well as the simulated results and conclusions. The simulation results show the positive and negative techno-economic impacts of the discussed strategy on the overall electricity system, while suggesting possible solutions.
High Speed In Situ Synchrotron Observation of Cyclic Deformation and Phase Transformation of Superelastic Nitinol at Ultrasonic Frequency
Authors: Fitzka M. , Rennhofer H. , Catoor D. , Reiterer M. , Lichtenegger H. , Checchia S. , di Michiel M. , Irrasch D. , Gruenewald T. A. , Mayer H. 
Published: December 2019

AbstractThe near equi-atomic intermetallic Ni Ti alloy Nitinol is used for medical implants, notably in self-expanding stent grafts and heart valve frames, which are subjected to several hundred million load cycles in service. Increasing the testing frequency to the ultrasonic range would drastically shorten the testing times and make the very-high cycle regime experimentally accessible. Such tests are, however, only meaningful if the material response at ultrasonic frequency is identical to that observed in conventional fatigue tests. A novel fatigue testing setup where superelastic Nitinol dog bone specimens are loaded at ultrasonic cycling frequency is presented. Loading conditions resemble in vivo loading (i.e., repeated cyclic loading with relatively small strain amplitudes, specimens in a pre-strained multi-phase state). Strains and phase transformations during ultrasonic frequency cycling are quantitatively measured in an X-ray diffraction (XRD) synchrotron experiment and compared to the material response at low frequency. The XRD experiment confirms that forward and reverse stress-induced phase transformation from austenite to martensite via the intermediate R-phase occurs during low frequency (0.1 Hz, strain rate $$ \dot{\varepsilon}\approx $$ε˙≈ 10−3 s−1) and ultrasonic frequency (20 kHz, $$ \dot{\varepsilon}\approx $$ε˙≈ 102 s−1) cycling. Since the same deformation mechanisms are active at low and ultrasonic frequency, these findings imply a general applicability of the ultrasonic fatigue testing technique to Nitinol.
What is Offshoring Management Capability and How Do Organizations Develop It? A Study of Dutch IT Service Providers
Authors: Mihalache Mashiho , Mihalache Oli R. 
Published: December 2019

AbstractThis study develops a capability perspective of offshoring. While previous research shows that experience affects future offshoring decisions, we still lack an understanding of what offshoring management capability is and how organizations develop it. Using data on five Dutch IT service providers, we find that offshoring management capability is multidimensional as it comprises four dimensions: coordination competency, relationship development, relationship design, and organizational identification. Furthermore, we uncover the process through which organizations can actively develop an offshoring management capability. We find that there are four elements in this learning loop: an offshoring growth mentality, adaptive monitoring of offshoring performance, offshoring reflexivity, and mechanisms for storing and disseminating offshoring best practice. Therefore, our capability perspective of offshoring provides a comprehensive conceptualization of offshoring management capability as a multidimensional construct and uncovers the process through which organizations develop it.
Is Metaphysics Immune to Moral Refutation?
Authors: Barber Alex 
Published: December 2019

AbstractWhen a novel scientific theory conflicts with otherwise plausible moral assumptions, we do not treat that as evidence against the theory. We may scrutinize the empirical data more keenly and take extra care over its interpretation, but science is in some core sense immune to moral refutation. Can the same be said of philosophical theories (or the non-ethical, ‘metaphysical’ ones at least)? If a position in the philosophy of mind, for example, is discovered to have eye-widening moral import, does that count against it at all? Actual responses by philosophers to the question of whether unanticipated moral consequences of metaphysical theories have evidential force are scattered, implicit, divergent, under-argued, and sometimes even self-undermining. The present discussion is, most immediately, an attempt to sort out the confusion. Beyond that, it exploits the new perspective this question gives us on a familiar topic: the relation of philosophy to science.
Study on the influence of voids on high-rise building on the wind environment
Authors: Li Yangluxi , Chen Lei 
Published: December 2019

AbstractThe purpose of this study was to investigate the effects of voids in tall buildings on the surrounding wind environment. With the development of modular technology, there has been a new method of building high-rise buildings. Currently, more and more high-rise buildings often use void spaces to reduce the wind resistance and utilize wind turbines by using wind power to create sky gardens. In this study, CFD (computer fluid dynamic) technology was used to simulate the wind environment around the buildings. The research focuses on the size, distribution and quantity of the concavity, which usually is defined as sky gardens. It is found that when the area of the opening is the same, the more number of opening, the more strengthened and distributed vertical wind velocity behind the building can be. The wind shadow area at the pedestrian height is further reduced. For holes distribution, the optimum ratio of the spacing between concavities to the void size for wind environment of tall buildings ranges from 1 to 3, which can disperse the surrounding heat in more efficiency and weaken the wind velocity in the lowest level. Therefore, in high-rise buildings, the number and distribution of the openings will have different effects on the wind environment around the buildings.
Incipient sympatric speciation via host race formation in Phengaris arion (Lepidoptera: Lycaenidae)
Authors: Bereczki Judit , Póliska Szilárd , Váradi Alex , Tóth János P. 
Published: December 2019

AbstractThe plausibility of sympatric speciation is still debated despite increasing evidence, such as host races in insects. This speciation process may be occurring in the case of the two phenological forms of the obligatorily myrmecophilous Phengaris arion. The main goal of our research was to study the nature and causes of difference between these forms focusing primarily on the incipient speciation via host races. Molecular analyses based on highly variable microsatellites together with Wolbachia screening, male genitalia morphometrics and host ant studies were carried out on four syntopic sample pairs. Our results show that the two phenological forms of P. arion may meet the criteria for host plant races. They coexist in sympatry in certain parts of the species range which is allowed by the adaptation to the distinct phenology of the host plants. Negative selection acts against the intermediate individuals which are on the wing in the inappropriate time frame. Thus, disruptive selection affects and produces bimodal distributions of phenotypes. However, the phenology of food plants is not entirely distinct and fluctuates year by year. Therefore, the two forms can exchange genes occasionally depending on the length of the time slot when they can meet with each other. Consequently, the reproductive isolation could not be completed and the existence of the two arion forms may represent only an incipient stage of sympatric speciation. It is also clear that Wolbachia is likely not a driver of sympatric speciation in this case.
Many Kinds of Poverty: Three Dimensions of Economic Hardship, Their Combinations, and Children’s Behavior Problems
Authors: Schenck-Fontaine Anika , Panico Lidia 
Published: December 2019

Abstract
Income poverty, material deprivation, and subjective financial stress are three distinct dimensions of economic hardship. The majority of the theoretical and empirical literature on the effects of economic hardship on children has treated material deprivation and subjective financial stress as only mediators of the effects of income poverty, not considering the independent effects of each dimension or the effects of their combinations. Using nationally representative, longitudinal data from the Millennium Cohort Study on more than 18,000 families in the United Kingdom, we propose seven distinct experiences of economic hardship, based on the possible combinations of income poverty, material deprivation, and subjective financial stress. We use mixed- and fixed-effects linear regression models to identify whether these different economic hardship combinations are differentially associated with children’s behavior problems between ages 3 and 7. We find that all economic hardship combinations, including those without income poverty, are associated with higher levels of children’s behavior problems. The combination of material deprivation and subjective financial stress and the combination of all three dimensions of economic hardship are associated with the highest levels of behavior problems. Based on these findings, we argue that income poverty is an important but insufficient measure of economic hardship for children and that theory and research on the effects of economic hardship on children should consider the multidimensional nature of economic stressors for families.
Diverticula in Male Lycorea halia Butterflies (Lepidoptera: Nymphalidae: Danaini: Itunina)—Support Organs for Everted Hairpencils with Unique Ultrastructure
Authors: Gnatzy W , Fischer O W , Kiesel A , Vane-Wright R I , Boppré M 
Published: December 2019

AbstractThe involvement of the diverticula, a synapomorphy for Itunina, in protrusion and expansion of hairpencils by male Lycorea halia (Hübner, 1816) is demonstrated for the first time. They facilitate maintaining the haemolymph pressure necessary to keep the hairpencils everted. The diverticula are curved hook-like lobes, open to the body cavity and densely filled with tracheae and threads made by units of two staggered cells surrounding a central extracellular fibril bundle. Such complex structures, apparently metabolically active, have not been reported for insects previously and might indicate additional functions, but their functional role(s) remains a puzzle. When a male emerges from pupa, the diverticula are not yet formed; this happens only during the first protrusion of the hairpencils.
A systematic review of the provision and efficacy of patient and carer information and support (PCIS) interventions for patients with dementia and their informal carers
Authors: Miles L. , McCausland B. M. S. , Patel H. P. , Amin J. , Osman-Hicks V. C. 
Published: December 2019

Abstract
Background
The NHS dementia strategy identifies patient and carer information and support (PCIS) as a core component of gold-standard dementia care. This is the first systematic review of PCIS, performed to analyse the literature and evidence for these interventions.

Aims
To systematically review literature evaluating the effectiveness of the provision of PCIS for people with dementia and their informal carers, in inpatient and outpatient settings.

Methods
Searches of four online biomedical databases, accessed in September 2018. Studies were selected if they were: relating to people with dementia or their informal carers, based in inpatient or outpatient settings, published in English-language peer-reviewed journals no earlier than the year 2000 and assessed dementia-related information or social support interventions, by measuring qualitative or quantitative carer or patient-reported outcomes. Standardised data extraction and quality appraisal forms were used.

Results
7 of 43 full-text papers analysed were eligible for analysis. 3 papers were different arms of one original study. Trends were present in the quantitative results towards reduced patient and carer depression and anxiety and the themes in the qualitative analysis were in favour of the intervention.

Conclusions
The studies analysed were too heterogeneous in design, population and outcomes measured to make a conclusive opinion about the efficacy of these interventions. It is surprising that for such a common condition, a gold-standard evidence-based intervention and standardised delivery for provision of PCIS for people living with dementia in the UK does not exist. Further research is therefore vital.
A semi-analytical approach to the elastic loading behaviour of rough surfaces
Authors: Zhang Xiaogang , Zhang Yali , Jin Zhongmin 
Published: December 2019

AbstractThe elastic loading behaviour of rough surfaces is derived based on the physical understanding of the contact phenomena, where the pressure distribution is analytically obtained without any negative values or convergence problems, thus the evolution of the contact behaviour is obtained in a semi-analytical manner. Numerical results obtained by the proposed approach facilitate the understanding of the contact behaviour in the following aspects: 1) the ratio of contact area to load decreases with an increase in real contact area; 2) normal approach-load relationship is approximated by an exponential decay under relatively small loads and a linear decay under relatively large loads; and 3) average gap shows an exponential relationship with load only in moderate load range.
Sylfjellet: a new outcrop of the Paleogene Van Mijenfjorden Group in Svalbard
Authors: Jochmann Malte Michel , Augland Lars Eivind , Lenz Olaf , Bieg Gerd , Haugen Turid , Grundvåg Sten Andreas , Jelby Mads E. , Midtkandal Ivar , Dolezych Martina , Hjálmarsdóttir Hanna Rósa 
Published: December 2019

AbstractA hitherto unrecognized Paleogene outcrop has been discovered at Sylfjellet, a mountain located at the northern side of Isfjorden, Svalbard. The strata, which cover an area of 0.8 km2, have until now been assigned to the Lower Cretaceous succession of the Adventdalen Group. In this study, the Sylfjellet site was studied in detail to provide an updated structural and sedimentological description of strata and lithostratigraphy. The age and burial history of the investigated succession were constrained by absolute (U/PB) and relative dating methods in addition to vitrinite reflectance analyses of coal seams. The results show a Paleogene age of the deposits, which is supported by the occurrence of an angiosperm pollen grain, plant macrofossils, and a tephra layer of early Selandian age (61.53 Ma). The 250 m-thick succession of Sylfjellet is assigned to the Firkanten, Basilika and Grumantbyen formations. This succession unconformably overlies the Lower Cretaceous Helvetiafjellet Formation. Sylfjellet is incorporated into the West Spitsbergen Fold-and-Thrust Belt and interpreted to be a fourth structural outlier of the Van Mijenfjorden Group. Vitrinite reflectance data indicate that at least 2000 m overburden has been eroded above the Sylfjellet coal seams, and that maximum burial of the strata predates folding and thrusting in the area.
Implementation of Time Temperature Indicators to Improve Temperature Monitoring and Support Dynamic Shelf Life in Meat Supply Chains
Authors: Albrecht Antonia , Ibald Rolf , Raab Verena , Reichstein Werner , Haarer Dietrich , Kreyenschmidt Judith 
Published: December 2019

AbstractBased on the well-investigated OnVu™ TTI kinetics, models were developed to adjust the label to different food products and predict the discolouration process under dynamic temperature conditions. After the successful validation under laboratory conditions, the applicability of the time temperature indicator (TTI) as shelf life indicator was tested in a national poultry chain. The TTI accurately reflected the temperature fluctuations occurring under real chain conditions. Shelf life predictions based on the discolouration of the TTIs were in accordance with the microbial shelf life of the product. The models were integrated in an online software tool to check for the compliance of the cold chain and predict the remaining shelf life of the product. The implementation of TTI and the software result in a valuable tool to support the decision-making process in the cold chain. The application of flexible shelf life enables the reduction of food waste in the meat supply chain.