bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser‐Guided Microcanvas Printing of Multicolor Upconversion Nanoparticles on Molybdenum Disulfide Monolayer
Authors: Poh Eng Tuan , Liu Xiaogang , Sow Chorng Haur 
Published: November 2019

AbstractScanning focused laser beams incident on nanomaterials have provided a nondestructive and facile technique to fabricate micropatterns of a wide variety of hybrid materials. Conventionally, the technique is limited to localized chemical modification or in situ reduction of specific metal ions en route to heterogeneous material systems. However, as hybrid structures continue to be an essential form to couple various material properties and bring forth nanostructures with designable traits, the need for a flexible technique to interface nanomaterials presynthesized in higher quality remains an important challenge. Herein, a technique for laser‐guided microcanvas formation by anchoring preformed upconversion nanoparticles at specific sites on a MoS2 monolayer surface is presented. The technique expands the building blocks in laser‐produced hybrid structures to include presynthesized nanomaterials. The upconversion microstructures are formed via a microbubble‐assisted mechanism, with distinct emission contrast against the background. The proof‐of‐concept production of a multicolor upconversion microcanvas marks the potential for full‐color high‐resolution displays while the technique opens up the possibility of fabricating an expandable range of new hybrid structures.
Palladium‐Catalyzed Selective Three‐Component Tandem Reaction to Bicyclic 1,2,3‐Triazole Derivatives
Authors: Duan Xinyu , Huang Xin , Fu Chunling , Ma Shengming 
Published: November 2019

AbstractA Pd‐catalyzed highly selective tandem reaction of allenynes, aryl or alkenyl iodides, and sodium azide for the synthesis of bicyclic 1,2,3‐triazole derivatives with a very broad substrate scope including mono‐substituted, 1,3‐disubstituted, and trisubstituted allenynes as well as different types of organic iodides has been reported. Control experiments showed that the reaction went through a cascade allene difunctionalization/Winstein allylic azide rearrangement/intramolecular azide‐alkyne cycloaddition process.magnified image
Signatures of a Charge Density Wave Phase and the Chiral Anomaly in the Fermionic Material Cobalt Monosilicide CoSi
Authors: Schnatmann Lauritz , Geishendorf Kevin , Lammel Michaela , Damm Christine , Novikov Sergey , Thomas Andy , Burkov Alexander , Reith Heiko , Nielsch Kornelius , Schierning Gabi 
Published: November 2019

AbstractMaterials with topological electronic states have emerged as one of the most exciting discoveries of condensed quantum matter, hosting quasiparticles with extremely low effective mass and high mobility. Weyl materials contain such topological states in the bulk and additionally have a non‐trivial chiral charge. However, despite known quantum effects caused by these chiral states, the interplay between chiral states, and a charge density wave phase, an ordering of the electrons to a correlated phase is not experimentally explored. Indications for the formation of a charge density wave phase in the Weyl material cobalt monosilicide CoSi are observed. Furthermore, the typical signatures of the charge density wave phase together with typical signatures of Weyl fermions in magnetic field dependent electrical transport characterization are investigated. The charge density wave and the chiral contribution to the electrical magneto‐transport are separated as well as a suppression of the charge density wave phase is observed in magnetic fields.
Toward Promising Cathode Catalysts for Nonlithium Metal–Oxygen Batteries
Authors: Mei Jun , Liao Ting , Liang Ji , Qiao Yanxin , Dou Shi Xue , Sun Ziqi 
Published: November 2019

AbstractThe success of Li–air/O2 batteries has brought extensive attention to the development of various promising non‐Li metal–O2 batteries, such as Zn–O2, Al–O2, Mg–O2 batteries, etc., which have exhibited unique advantages, such as low production cost, high energy density, and much enhanced safety. The versatile non‐Li metal–O2 batteries provide a better opportunity for meeting the practical requirements for sustainable energy supplies in various applications. A high‐performance cathode in non‐Li metal–O2 batteries that can effectively trigger both oxygen reduction and evolution reactions and thus boost the overall battery performance is of great research interest. In this article, a comprehensive review on the development of Li‐free metal–O2 batteries and particularly focusing on the oxygen catalytic cathodes for both primary and secondary non‐Li metal–O2 batteries is carefully performed. The current challenges and potential solutions are also outlined and proposed. Through carefully selecting and rationally designing promising catalytic cathodes, a series of non‐Li metal–oxygen batteries toward practical energy storage applications are highly anticipated.
In Situ Mechanistic Elucidation of Superior Si‐C‐Graphite Li‐Ion Battery Anode Formation with Thermal Safety Aspects
Authors: Parekh Mihit H. , Sediako Anton D. , Naseri Ali , Thomson Murray J. , Pol Vilas G. 
Published: November 2019

AbstractA composite anode material synthesized using silicon nanoparticles, micrometer sized graphite particles, and starch‐derived amorphous carbon (GCSi) offers scalability and enhanced electrochemical performance when compared to existing graphite anodes. Mechanistic elucidation of the formation steps of tailored GCSi composite are achieved with environmental transmission electron microscopy (ETEM) and thermal safety aspects of the composite anode are studied for the first time using specially designed multimode calorimetry for coin cell studies. Electrochemical analysis of the composite anode demonstrates a high initial discharge capacity (1126 mAh g−1) and yields a high coulombic efficiency of 83% in the first charge cycle. Applying a current density of 500 mA g−1, the anode composite retains 448 mAh g−1 specific capacity after 100 cycles. Cycling stability is a result of improved interfacial binding made possible by the interconnected architecture of wheat derived amorphous carbon, enhancing the electrochemical kinetics and decreasing the inherent issues associated with volume expansion and pulverization of pristine Si electrodes. Comparing the energy released during thermal runaway, per specific capacity for the full‐cell, the GCSi composite releases less heat than the conventional graphitic anode, suggesting a synergistic effect of each ingredient of the GCSi composite, providing a safer and higher performing anode.
Comparing endoscopic resection and open resection for management of sinonasal mucosal melanoma
Authors: Farber Nicole I. , Bavier Richard D. , Crippen Meghan M. , Vatsa Nishant , Hsueh Wayne D. , Eloy Jean Anderson 
Published: November 2019

BackgroundSinonasal mucosal melanoma (SMM) is a rare, aggressive cancer, optimally managed with complete surgical resection. This study aimed to assess the impact of surgical approach on outcomes by comparison of cases managed with open vs endoscopic resection.MethodsThe National Cancer Database 2010–2015 datasets were queried for all cases of non‐metastatic SMM initially managed with definitive surgery. Patients were grouped according to surgical approach (open vs endoscopic) and compared for patient, tumor, and treatment variables using chi‐square analyses. Case‐control matching was used to generate subgroups of cases paired 1:1 between groups, matched for significantly distributed variables. Subgroups were compared for perioperative outcomes and overall survival (OS) using Kaplan‐Meier analyses.ResultsOf the 686 cases of SMM managed with definitive surgery, 46.2% were treated endoscopically. Open and endoscopic groups did not differ significantly by T‐stage, primary site, or rates of adjuvant therapies. Case‐control matching for these variables generated a subpopulation of 240 paired cases. Comparison of matched groups found no significant differences in 30‐day or 90‐day mortality. Endoscopically managed patients had higher rates of unplanned readmission whereas open resection patients had longer length of stay (LOS). There was no significant difference in OS between groups.ConclusionIn surgically managed SMM, open resection patients have significantly longer LOS, whereas endoscopic patients have higher rates of unplanned readmission. Surgical approach does not appear to influence OS.
4,4′‐Diaminodiphenylsulfone; an efficient co‐additive in dye‐sensitized nanocrystalline TiO2 solar cells
Authors: Afrooz Malihe , Bagheri Omid , Dehghani Hossein 
Published: November 2019

The effect of 4,4′‐diaminodiphenylsulfone (DADPS) as a co‐additives in iodide/triiodide redox electrolyte on the performance of dye‐sensitized solar cell based on the 2‐cyano‐3‐(4‐(diphenylamino)phenyl)acrylic acid (TPA) and 2‐cyano‐3‐(2΄‐(5΄,10΄,15΄,20΄‐ tetraphenylporphyrinato Zinc (II)yl) acrylic acid (Zn‐1) dyes have been investigated. Compared withstandard electrolyte (0.1 M LiI, 0.05 M I2, 0.6 M 1‐butyl‐2,3‐dimethylimidazolium iodide (BDMII) and TBP (0.5, 1 M)), adding 0.5 M of DADPS, as a co‐additive, into the electrolyte system has caused increasing short current density (Jsc) and open‐circuit potential (Voc) consequently the energy conversion (η) improved. Electrochemical impedance results indicate adsorbing of DADPS on the titanium dioxide surface leads to an increase in the lifetime (τ). Adsorbing of DADPS on the semiconductor surface retards the interfacial charge recombination that has a beneficial effect on the Voc and Jsc. The results showed that amine groups of DADPS attach to the conduction band (CB) of TiO2 film and suppress the electron recombination process and as a result, it can be applied as a promising co‐additive in DSSCs.
Nickel‐Catalyzed Reductive Coupling for Transforming Unactivated Aryl Electrophiles into β‐Fluoroethylarenes
Authors: Yang Yi , Luo Gen , Li Youlin , Tong Xia , He Mengmeng , Zeng Hongyao , Jiang Yan , Liu Yingle , Zheng Yubin 
Published: November 2019

AbstractWe report herein a facile synthetic method for converting unactivated (hetero)aryl electrophiles into β‐fluoroethylated (hetero)arenes via nickel‐catalyzed reductive cross‐couplings. This coupling reaction features the involvement of FCH2CH2 radical intermediate rather than β‐fluoroethyl manganese species which provides effective solutions to the problematic β‐fluoride side eliminations. The practical value of this protocol is further demonstrated by the late‐stage modification of several complex ArCl or ArOH‐derived bioactive molecules.
Individual and group advice taking in judgmental forecasting: Is group forecasting superior to individual forecasting?
Authors: Kim Hyo Young , Lee Yun Shin , Jun Duk Bin 
Published: November 2019

AbstractWe examined how individuals and groups behave in making judgmental forecasts when they are given external forecast advice. We compare individual and group advice‐taking behavior under different conditions: (a) when advice quality is fixed, (b) when advice quality is randomly varied, and (c) when there is feedback on advice quality or not. Participants in Study 1 received fixed advice of either reasonable or unreasonable quality while making their decisions. Participants in Study 2 randomly received both reasonable and unreasonable advice. We found in both studies that groups feel more confident than individuals. This greater confidence decreased the groups' reliance on advice. We also found that groups are better than individuals at discerning the quality of advice. In the group treatment, the group's reliance on advice increased according to the degree of disagreement with the initial decisions of the group members. In Study 3, participants randomly received both reasonable and unreasonable advice, and in addition, they received feedback on actual realizations that enabled them to learn about the quality of advice. In the presence of feedback on random advice quality, groups are no longer less receptive to advice than individuals; with feedback, both individuals and groups discount advice more than they do without feedback. Nevertheless, groups are still better than individuals at discerning the quality of advice. We conclude that group forecasting is better than individual forecasting across various conditions that we investigate except when advice quality is known to be consistently reliable.
Why a Constant Number of Vertebrae? Digital Control of Segmental Identity during Vertebrate Development
Authors: Kudlicki Andrzej 
Published: November 2019

AbstractIt is not understood how the numbers and identities of vertebrae are controlled during mammalian development. The remarkable robustness and conservation of segmental numbers may suggest the digital nature of the underlying process. The study proposes a mechanism that allows cells to obtain and store the segmental information in digital form, and to produce a pattern of chromatin accessibility that in turn regulates Hox gene expression specific to the metameric segment. The model requires that a regulatory element be present such that the number of occurrences of the motif between two consecutive Hox genes equals the number of segments under the control of the anterior gene. This is true for the recently discovered hydroxyl radical cleavage 3bp‐periodic (HRC3) motif, associated with histone modifications and developmental genes. The finding not only allows the correct prediction of the numbers of segments using only sequence information, but also resolves the 40‐year‐old enigma of the function of temporal and spatial collinearity of Hox genes. The logic of the mechanism is illustrated in the attached animated video. How different aspects of the proposed mechanism can be tested experimentally is also discussed.
Associations between blood cultures after surgery for colorectal cancer and long-term oncological outcomes
Authors: Watt S K , Fransgaard T , Degett T H , Thygesen L C , Benfield T , Knudsen J D , Fuursted K , Jensen T G , Dessau R B , Schønheyder H C , Møller J K , Gögenur I 
Published: November 2019

Abstract

Background
Systemic inflammation following curative surgery for colorectal cancer may be associated with increased risk of recurrence. [Correction added on 29 November 2019, after first online publication: text amended for accuracy.] This study investigated whether a clinically suspected infection, for which blood cultures were sent within 30 days after surgery for colorectal cancer, was associated with long-term oncological outcomes.

Methods
This register-based national cohort study included all Danish residents undergoing surgery with curative intent for colorectal cancer between January 2003 and December 2013. Patients who developed recurrence or died within 180 days after surgery were not included. Associations between blood cultures taken within 30 days after primary surgery and overall survival, disease-free survival and recurrence-free survival were analysed using Cox regression models adjusted for relevant clinical confounders, including demographic data, cancer stage, co-morbidity, blood transfusion, postoperative complications and adjuvant chemotherapy.

Results
The study included 21 349 patients, of whom 3390 (15·9 per cent) had blood cultures taken within 30 days after surgery. Median follow-up was 5·6 years. Patients who had blood cultures taken had an increased risk of all-cause mortality (hazard ratio (HR) 1·27, 95 per cent c.i. 1·20 to 1·35; P &lt; 0·001), poorer disease-free survival (HR 1·22, 1·16 to 1·29; P &lt; 0·001) and higher risk of recurrence (HR 1·15, 1·07 to 1·23; P &lt; 0·001) than patients who did not have blood cultures taken.

Conclusion
A clinically suspected infection requiring blood cultures within 30 days of surgery for colorectal cancer was associated with poorer oncological outcomes.
Current trends in isotope‐coded derivatization liquid chromatographic‐mass spectrometric analyses with special emphasis on their biomedical application
Authors: El‐Maghrabey Mahmoud H. , Kishikawa Naoya , Kuroda Naotaka 
Published: November 2019

AbstractCurrently, LC–MS has various applications in different areas such as metabolomics, pharmacokinetics, and pathological studies. Yet, matrix effects resulting from co‐existing constituents remain a major problem for LC–MS [or LC–tandem mass spectrometry (LC–MS/MS)]. Moreover, technical problems and instrumental drifts may lead to ion abundance variance. Thus, an internal standard (IS) is required to guarantee the accuracy and precision of the method. Because of their limited number, isotope‐coded derivatization (ICD) has been recently introduced to overcome this problem. For ICD, a stable heavy isotope‐coded moiety is used for labeling the standard or the control sample and the formed products can act as ISs. A light form of the reagent is used for labeling the sample. Then, both are mixed and analyzed by LC–MS(/MS). This strategy permits the identification of different unknown analytes including potential metabolites and disease biomarkers. All these attributes lead to persistent growth in the applications of ICD LC–MS(/MS) in various biomedical branches. In this article we review the ICD methods published in the last eight years for biomedical applications as well as briefly summarize other applications for environmental and food analyses as some of their used ICD reagents were further applied for analyzing biological specimens or have the potential for that.
SH‐SY5Y and LUHMES cells display differential sensitivity to MPP+, tunicamycin, and epoxomicin in 2D and 3D cell culture
Authors: Ko Kristin Robin , Tam Nicky W. , Teixeira Alyne G. , Frampton John P. 
Published: November 2019

AbstractSH‐SY5Y and LUHMES cell lines are widely used as model systems for studying neurotoxicity. Most of the existing data regarding the sensitivity of these cell lines to neurotoxicants have been recorded from cells growing as two‐dimensional (2D) cultures on the surface of glass or plastic. With the emergence of 3D culture platforms designed to better represent native tissue, there is a growing need to compare the toxicology of neurons grown in 3D environments to those grown in 2D to better understand the impact that culture environment has on toxicant sensitivity. Here, a simple 3D culture method was used to assess the impact of growth environment on the sensitivity of SH‐SY5Y cells and LUHMES cells to MPP+, tunicamycin, and epoxomicin, three neurotoxicants that have been previously used to generate experimental models for studying Parkinson's disease pathogenesis. SH‐SY5Y cell viability following treatment with these three toxicants was significantly lower in 2D cultures as compared to 3D cultures. On the contrary, LUHMES cells did not show significant differences between growth conditions for any of the toxicants examined. However, LUHMES cells were more sensitive to MPP+, tunicamycin, and epoxomicin than SH‐SY5Y cells. Thus, both the choice of cell line and the choice of growth environment must be considered when interpreting in vitro neurotoxicity data.
Sheathless guiding catheter from a femoral approach for complex percutaneous coronary interventions —An unusual solution for an often‐encountered problem
Authors: Israeli Zeev , Nordkin Irina , Goldberg Alexander , Halabi Majdi 
Published: November 2019

AbstractSheathless guiding catheters are a valuable tool in the catheterization labor and may assist the operator when dealing with heavily calcified and tortuous vessels. Nevertheless, when hostile anatomy prevents successful percutaneous coronary interventions (PCI) from the radial access, transfemoral use of sheathless guide can assist in overcoming these challenges in a safe manner.
Ultrasensitive Detection of ctDNA by Target‐Mediated In Situ Growth of DNA Three‐Way Junction on the Electrode
Authors: Chen Xifeng , Tang Yuguo , Yan Ruhong , Miao Peng 
Published: November 2019

AbstractCirculation tumor DNA (ctDNA) is an emerging biomarker for diagnosis and therapy of cancers. Herein, an ultrasensitive electrochemical method for ctDNA quantification is developed by in situ growth of DNA three‐way junction on the electrode. Three hairpin‐structured DNA probes are used as fuel strands and strand‐displacement polymerization reactions are initiated by target ctDNA for the in situ growth of the DNA junction structure, which changes the electron transfer pathways of electrochemical species. By further employing a reductant‐mediated amplification, the method shows sub‐femtomolar sensitivity. Meanwhile, specific analysis of ctDNA is achieved with negligible interference by DNAs with one or more mismatched sites. Therefore, the proposed method may have great analytical and clinical applications.
Versatile Bispidine‐Based Bifunctional Chelators for 64CuII‐Labelling of Biomolecules
Authors: Singh Garima , Zarschler Kristof , Hunoldt Sebastian , Martínez Irma Ivette Santana , Ruehl Carmen L. , Matterna Madlen , Bergmann Ralf , Máthé Domokos , Hegedüs Nikolett , Bachmann Michael , Comba Peter , Stephan Holger 
Published: November 2019

AbstractBifunctional chelators as parts of modular metal‐based radiopharmaceuticals are responsible for stable complexation of the radiometal ion and for covalent linkage between the complex and the targeting vector. To avoid loss of complex stability, the bioconjugation strategy should not interfere with the radiometal chelation by occupying coordinating groups. The C9 position of the very stable CuII chelator 3,7‐diazabicyclo[3.3.1]nonane (bispidine) is virtually predestined to introduce functional groups for facile bioconjugation as this functionalisation does not disturb the metal binding centre. We describe the preparation and characterisation of a set of novel bispidine derivatives equipped with suitable functional groups for diverse bioconjugation reactions, including common amine coupling strategies (bispidine‐isothiocyanate) and the Cu‐free strain‐promoted alkyne–azide cycloaddition. We demonstrate their functionality and versatility in an exemplary way by conjugation to an antibody‐based biomolecule and validate the obtained conjugate in vitro and in vivo.
Pseudo‐Gated Adsorption with Negligible Volume Change Evoked by Halogen‐Bond Interaction in the Nanospace of MOFs
Authors: Kanoo Prakash , Matsuda Ryotaro , Sato Hiroshi , Li Liangchun , Hosono Nobuhiko , Kitagawa Susumu 
Published: November 2019

AbstractThe enhancement of gas adsorption utilizing weak interactions in porous compounds is highly demanding for the design of energy‐efficient storage materials. Here, we present a rational design for such an adsorption process by using synergistic functions between dynamic motion in a local module and weak but specific host–guest interactions, that is, halogen‐bond (XB) interactions in metal–organic frameworks (MOFs). We designed a new porous coordination polymer (PCP), that is, Br‐PCP, the pore surfaces of which are decorated with −CH2Br groups and could be useful for interaction with CO2 molecules. In accordance with our anticipation, in‐situ studies suggest that the adsorption step at approximately 54 kPa during CO2 adsorption is indeed facilitated by XB interactions with little change in the structural volume. This approach of integrating flexible XB modules in rigid PCPs is applicable for designing advanced gas storage systems.