bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase III comparative study of nivolumab (anti-PD-1; BMS-963558; ONO-4538) versus docetaxel in patients (pts) with previously treated advanced/metastatic nonsquamous non-small-cell lung cancer (NSCLC).
Authors: Gettinger Scott N. , Brahmer Julie R. , Rizvi Naiyer A. , Ready Neal , Chow Laura Quan Man , Antonia Scott J. , Buyse Marc E. , Jassem Jacek , Finckenstein Friedrich Graf , Crinò Lucio , Lynch Thomas James 
Published: March 2020

TPS8121 Background: Lung cancer is the leading cause of cancer mortality globally. Non-squamous NSCLC represents up to 75% of NSCLC cases with most pts diagnosed with advanced disease, which progresses rapidly following failure of 1st-line platinum-based doublet (Pt-doublet) chemotherapy. Benefit from current therapies has reached a plateau with median overall survival (OS) for late stage NSCLC pts of 10-12 months. Standard 2nd-line therapy (single-agent chemotherapy; eg. docetaxel) results in OS of 8 months. Expression of programmed death-1 (PD-1), an immune checkpoint receptor that negatively regulates T-cell activation, is associated with poor prognosis in NSCLC. Nivolumab, a PD-1 receptor blocking antibody, prevents activation of PD-1 by its known ligands, PD-L1 and PD-L2, and demonstrated durable antitumor activity in NSCLC pts in a phase 1 study (Topalian ST, et al. N Engl J Med 2012). We present a phase III study comparing OS benefit of nivolumab vs docetaxel in pts with metastatic/recurrent non-squamous NSCLC. Methods: In this study, 574 pts will be randomized 1:1 to receive nivolumab 3 mg/kg IV q 2 weeks (wks) or docetaxel 75 mg/m2 q 3 wks until disease progression or unacceptable toxicity. Pts will include those having progressed during/after Pt-doublet ± bevacizumab (bev) for advanced disease as well as pts with EGFR-mutant or ALK-rearranged NSCLC who have progressed following treatment with a tyrosine kinase inhibitor (TKI) and a Pt-doublet ± bev. Prior maintenance therapy with erlotinib, pemetrexed and/or bev is allowed. Pts will be stratified by prior use of maintenance therapy and receipt of 1 vs 2 (Pt doublet and TKI) prior lines of therapy. Response will be assessed (modified RECIST 1.1) at 9 wks following treatment initiation and every 6 wks thereafter until disease progression. The primary objective is to compare the OS of nivolumab vs docetaxel treated pts. Secondary objectives include comparison of objective response rates, progression-free survival and disease related symptom progression, and evaluation of clinical benefit of nivolumab vs docetaxel in PD-L1+ vs PD-L1- tumor subgroups. Clinical trial information: NCT01673867.
AHL 2011: A Lysa randomized phase III study of a treatment driven by early PET response compared to a standard treatment in patients with Ann Arbor stage III-IV or high-risk IIB Hodgkin lymphoma.
Authors: Casasnovas Rene-Olivier , Meignan Michel , Reman Oumedaly , Gaillard Isabelle , Stamatoullas Aspasia , Brice Pauline , Salles Gilles A. , Bouabdallah Reda , Bologna Serge , Nicolas-Virelizier Emmanuelle , Morschhauser Franck , Janvier Maud , Andre Marc , Berriolo-Riedinger Alina , Traverse-Glehen Alexandra , Edeline Veronique , Dartigues Peggy , Parrens Marie , Mounier Nicolas , Ferme Christophe 
Published: March 2020

TPS8615 Background: ABVD is the most widely chemotherapy regimen used as standard treatment of advanced Hodgkin lymphoma (HL). The escalated BEACOPP (BEAesc) regimen which delivers more drugs at higher dose intensity was shown to improve patient’s PFS but not OS when compared to ABVD (Federico M, 2009; Viviani S, 2011; Carde P, 2012). The better efficiency of BEAesc is associated to a marked immediate hematologic toxicity and a higher risk of secondary myelodysplasia/leukemia. Also, the gonadal toxicity which is a real concern in young women, is quite higher when using BEAesc. So, to better manage HL treatment we need to identify early responding patients able to benefit from a strategy of dose intensity decrease after upfront BEAesc, without impairing the disease control. PET performed after 2 cycles of chemotherapy (PET2) might identify such a population suitable for receiving ABVD after 2 cycles of upfront BEAesc, and was implemented in the present study. Methods: The AHL 2011 trial (NCT01358747) was designed to test in 16 to 60 years old HL patients with Ann Arbor stage III, IV or high risk IIB, a treatment strategy driven by PET after 2 cycles of BEACOPPesc, delivering 4 cycles of ABVD for PET2 negative patients and 4 cycles of BEAesc for PET2 positive patients, compared to a treatment not monitored by PET, delivering the best BEAesc schedule consisting in 6 cycles of this regimen (Engert A, 2012). A baseline PET is mandatory before treatment and PET2 are centrally reviewed within 48 hours and interpreted according to Deauville criteria. The allocation of treatment in the experimental arm is based on the PET2 central review result. PFS is the primary endpoint of the study with an hypothesis of non-inferiority of the experimental arm with a margin of 10% (85% 5y-PFS in the control arm vs >75% in the experimental arm). With a 6-year of accrual period, inclusion of 405 patients in each arm would have 80% power to detect a HR of 1.77 using a one-sided log rank test with significance level of 0.025. The trial started in May 2011 and to date, 385 patients have been enrolled. The DSMC reviewed the trial in November 2012 and suggested that the trial continue as planned. Clinical trial information: NCT01358747.
A phase III, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of idelalisib (GS-1101) in combination with rituximab for previously treated indolent non-Hodgkin lymphomas (iNHL).
Authors: Leonard John , Zinzani Pier Luigi , Jurczak Wojciech , Rummel Mathias J. , Salles Gilles A. , Kimby Eva , Arkenau Hendrik-Tobias , Davies Andrew John , Johnson David Michael , Evans Shelley , Dansey Roger D. , Godfrey Wayne R. , Kahl Brad S. 
Published: March 2020

TPS8617 Background: PI3K-delta is critical for activation, proliferation and survival of B cells and plays a role in homing and retention in lymphoid tissues. PI3Kδ signaling is hyperactive in many B-cell malignancies. Idelalisib is a first-in-class, targeted, highly selective, oral inhibitor of PI3Kδ that reduces proliferation, enhances apoptosis, and inhibits homing and retention of malignant B cells in lymphoid tissues (Lannutti et al, 2011). Phase 1 trials demonstrated that idelalisib is highly active in pts with heavily pretreated iNHL: pts experienced reductions in disease-associated chemokines, profound and rapid reductions in lymphadenopathy, and durable clinical benefit with acceptable safety profile (de Vos et al, 2011). Methods: 375 pts with previously treated iNHL, who have measurable lymphadenopathy, have received prior anti-CD20-antibody-containing therapy, and who have iNHL that is not refractory to rituximab (R) are randomized in a 2:1 ratio into Arm A or Arm B. In Arm A, pts receive idelalisib at 150 mg BID continuously + R at 375 mg/m2 (weekly x 4 then every 8 weeks x 4). In Arm B, pts receive placebo BID instead of idelalisib. Stratification factors include tumor type (follicular lymphoma vs others), tumor burden (high vs low), and time since completion of last prior therapy for iNHL (<18 months vs ≥18 months). The primary endpoint is PFS and key secondary endpoints include ORR, lymph node response rate, CR rate, and OS. This is an event-driven trial and primary endpoint evaluation will be based on independent central review. For the primary efficacy analysis, the difference in PFS between the treatment arms will be assessed in the ITT analysis set using Kaplan-Meier methods and the stratified log-rank test. The study opened for enrollment in Dec 2012 (NCT01732913). Clinical trial information: NCT01732913.
Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation
Authors: Zhu Qi , Weng Jonathan , Shen Minqian , Fish Jace , Shen Zhujun , Coschigano Karen T , Davidson W Sean , Tso Patrick , Shi Haifei , Lo Chunmin C 
Published: March 2020

Abstract
Apolipoprotein A-IV (ApoA-IV) synthesized by the gut regulates lipid metabolism. Sympathetic innervation of adipose tissues also controls lipid metabolism. We hypothesized that ApoA-IV required sympathetic innervation to increase fatty acid (FA) uptake by adipose tissues and brown adipose tissue (BAT) thermogenesis. After 3 weeks feeding of either a standard chow diet or a high-fat diet (HFD), mice with unilateral denervation of adipose tissues received intraperitoneal administration of recombinant ApoA-IV protein and intravenous infusion of lipid mixture with radioactive triolein. In chow-fed mice, ApoA-IV administration increased FA uptake by intact BAT but not the contralateral denervated BAT or intact white adipose tissue (WAT). Immunoblots showed that, in chow-fed mice, ApoA-IV increased expression of lipoprotein lipase and tyrosine hydroxylase in both intact BAT and inguinal WAT (IWAT), while ApoA-IV enhanced protein levels of β3 adrenergic receptor, adipose triglyceride lipase, and uncoupling protein 1 in the intact BAT only. In HFD-fed mice, ApoA-IV elevated FA uptake by intact epididymal WAT (EWAT) but not intact BAT or IWAT. ApoA-IV increased sympathetic activity assessed by norepinephrine turnover (NETO) rate in BAT and EWAT of chow-fed mice, whereas it elevated NETO only in EWAT of HFD-fed mice. These observations suggest that, in chow-fed mice, ApoA-IV activates sympathetic activity of BAT and increases FA uptake by BAT via innervation, while in HFD-fed mice, ApoA-IV stimulates sympathetic activity of EWAT to shunt FAs into the EWAT.
Skeletal stem cells: insights into maintaining and regenerating the skeleton
Authors: Serowoky Maxwell A. , Arata Claire E. , Crump J. Gage , Mariani Francesca V. 
Published: March 2020

ABSTRACT
Skeletal stem cells (SSCs) generate the progenitors needed for growth, maintenance and repair of the skeleton. Historically, SSCs have been defined as bone marrow-derived cells with inconsistent characteristics. However, recent in vivo tracking experiments have revealed the presence of SSCs not only within the bone marrow but also within the periosteum and growth plate reserve zone. These studies show that SSCs are highly heterogeneous with regard to lineage potential. It has also been revealed that, during digit tip regeneration and in some non-mammalian vertebrates, the dedifferentiation of osteoblasts may contribute to skeletal regeneration. Here, we examine how these research findings have furthered our understanding of the diversity and plasticity of SSCs that mediate skeletal maintenance and repair.
Connecting brain to behaviour: a role for general purpose steering circuits in insect orientation?
Authors: Steinbeck Fabian , Adden Andrea , Graham Paul 
Published: March 2020

ABSTRACT
The lateral accessory lobes (LALs), paired structures that are homologous among all insect species, have been well studied for their role in pheromone tracking in silkmoths and phonotaxis in crickets, where their outputs have been shown to correlate with observed motor activity. Further studies have shown more generally that the LALs are crucial both for an insect's ability to steer correctly and for organising the outputs of the descending pathways towards the motor centres. In this context, we propose a framework by which the LALs may be generally involved in generating steering commands across a variety of insects and behaviours. Across different behaviours, we see that the LAL is involved in generating two kinds of steering: (1) search behaviours and (2) targeted steering driven by direct sensory information. Search behaviours are generated when the current behaviourally relevant cues are not available, and a well-described LAL subnetwork produces activity which increases sampling of the environment. We propose that, when behaviourally relevant cues are available, the LALs may integrate orientation information from several sensory modalities, thus leading to a collective output for steering driven by those cues. These steering commands are then sent to the motor centres, and an additional efference copy is sent back to the orientation-computing areas. In summary, we have taken known aspects of the neurophysiology and function of the insect LALs and generated a speculative framework that suggests how LALs might be involved in steering control for a variety of complex real-world behaviours in insects.
Anharmonic Vibrational Analysis of Ethylene, Butadiene, and Longer Conjugated Alkenes by Double-Hybrid Density-Functional Theory Calculations
Authors: Furuya Kazuhiko , Sakamoto Akira , Tasumi Mitsuo 
Published: March 2020

Abstract
The anharmonic vibrational wavenumbers of ethylene, trans-1,3-butadiene, and conjugated all-trans alkenes (1,3,5-hexatriene, 1,3,5,7-octatetraene, and 1,3,5,7,9-decapentaene) were calculated by using the double-hybrid density-functional method. The coefficients of terms constituting the energy in the default double-hybrid density-functional (B2PLYP) were carefully optimized for ethylene. Calculations using this modified double-hybrid density-functional (B2ePLYP) gave anharmonic vibrational wavenumbers for the above-mentioned molecules in satisfactory agreement with the published data on fundamentals, overtones, and combinations. Isotope effects observed for deuterated species were mostly well reproduced.
Η Χρήση νέων τεχνολογιών στη διδασκαλία της γεωμετρίας στο γυμνάσιο: η σχέση τους με τα κίνητρα επίτευξης και την επίδοση των μαθητών
Authors: ΔΙΑΜΑΝΤΟΠΟΥΛΟΥ ΔΑΝΑΗ – ΜΑΡΙΑ , ΚΑΛΟΓΕΡΟΠΟΥΛΟΥ ΖΩΗ 
Published: March 2020

Η παρούσα έρευνα είχε ως βασικό στόχο να διερευνήσει το κατά πόσο η χρήση των νέων τεχνολογιών στα σχολεία επηρεάζει τις πεποιθήσεις κινήτρων και την επίδοση των μαθητών/τριών στο μάθημα της Γεωμετρίας, όταν αυτό διδάσκεται με αυτόν τον τρόπο. Στο πλαίσιο της παρούσας διπλωματικής εργασίας υιοθετήθηκε η θεωρία Προσδοκίας- Αξίας (Κόστος) και ως πεποιθήσεις κινήτρων εξετάστηκαν οι πεποιθήσεις αυτοαποτελεσματικότητας. Επιπλέον, διερευνήθηκε η σχέση μεταξύ των πεποιθήσεων αυτοαποτελεσματικότητας και των προσδοκιών επιτυχίας, αξίας έργου και κόστους. Στην έρευνα συμμετείχαν 43 μαθητές της Β’ Γυμνασίου του σχολείου τηςΝ. Μηχανιώνας στη Θεσσαλονίκη, οι οποίοι απάντησαν σε ένα ερωτηματολόγιο το οποίο περιελάμβανε 2 κλίμακες αυτο-αναφοράς. Τα αποτελέσματα της έρευνας έδειξαν πως δεν υπήρξε στατιστικώς σημαντική διαφορά στις απαντήσεις των μαθητών όσον αφορά τις προαναφερθείσες μεταβλητές για τις δύο συνθήκες που μελετήθηκαν, δηλαδή τη διδασκαλία του μαθήματος της Γεωμετρίας με τη χρήση τεχνολογικών μέσων και αυτή που γίνεται με τον παραδοσιακό τρόπο. Αναφορικά με τις σχέσεις μεταξύ των μεταβλητών,βρέθηκε ότι η αυτοαποτελεσματικότητα συσχετίζεται θετικά με τις προσδοκίες επιτυχίας και με την αξία του μαθήματος, ενώ συσχετίζεται αρνητικά με το κόστος. Επιβεβαιώνοντας την υπάρχουσα βιβλιογραφία, βρέθηκε θετική συσχέτιση των προσδοκιών επιτυχίας με την αξία έργου και αρνητική συσχέτιση αυτών με το κόστος.
Προγνωστικοί παράγοντες γλωσσικής ανάπτυξης παιδιών με κοχλιακό εμφύτευμα
Authors: Μπίνος Πάρης , Λοίζου Έλενα 
Published: March 2020

Εισαγωγή: Στόχος όλων των παιδιών που έλαβαν Κοχλιακό Εμφύτευμα (ΚΕ) πρέπει να είναι η ανάπτυξη της ομιλίας και η συγκρίσιμη γλωσσική ανάπτυξη με συνομηλίκους φυσιολογικής ακοής. Μέχρι και το 2011 υπολογίζεται ότι περίπου 80.000 νήπια και παιδιά έχουν λάβει ΚΕ ως λύση στο πρόβλημα της απώλειας ακοής τους. Σύγχρονα δεδομένα δείχνουν πως όσα παιδιά λαμβάνουν ΚΕ πριν την ηλικία των δύο ετών, με μέσο όρο καθαρών τόνων (PTA) άνω των 65 dB πριν το χειρουργείο και χωρίς άλλες δυσκολίες θα έχουν τις καλύτερες προϋποθέσεις γλωσσικής ανάπτυξης. Πώς όμως επηρεάζεται η γλωσσική ανάπτυξη ειδικότερα; Ποιοι είναι εκείνοι οι προγνωστικοί παράγοντες που συνδέονται με κάθε υποσύστημα της γλώσσας και μπορούμε να στοχεύσουμε ώστε να παρέχουμε πρώιμη παρέμβαση; Σκοπός: Σκοπός της παρούσας μελέτης είναι να αναδείξει τους προγνωστικούς παράγοντες που συνδέονται με κάθε υποσύστημα της γλώσσας. Η ταξινόμηση των παραγόντων θα συμβάλει στην καλύτερη Λογοθεραπευτική παρέμβαση και τροποποίηση των αντίστοιχων πρακτικών.Ευρήματα: Η έρευνα έχει αξιολογήσει πλήθος προγνωστικών παραγόντων. Εδώ παρουσιάζονται δεδομένα για το φύλο, την χρονολογική ηλικία, την αιτιολογία της κώφωσης, την ηλικία πρώτης εμφύτευσης, παράγοντες της διαδικασίας της παιδιατρικής ακουστικής παρέμβασης, την γνώση μιας ή περισσοτέρων γλωσσών, την ένταξη σε κατάλληλο σχολικό πλαίσιο, τον βαθμό ανάμιξης των γονέων στην παρέμβαση και το κοινωνικο-οικονομικό υπόβαθρο της οικογένειας. Κάθε παράγοντας συνδέθηκε με αντίστοιχο γλωσσικό υποσύστημα.Συμπεράσματα: Η εύρεση του τρόπου επηρεασμού κάθε προγνωστικού παράγοντα στην εξέλιξη της γλωσσικής ανάπτυξης αποτελεί αναγκαίο βήμα για την διαμόρφωση κατάλληλων τεχνικών παρέμβασης της Λογοθεραπείας.
Παιχνίδι και καταστασιακή μάθηση σε παιδιά προσχολικής ηλικίας
Authors: Ντίνου Βερονίκη 
Published: March 2020

Η παρούσα εργασία αφορά στην ανάπτυξη των δεξιοτήτων παιδιών προσχολικής ηλικίας σε συνθήκες καταστασιακής μάθησης κατά τη διάρκεια του παιχνιδιού. Πιο συγκεκριμένα, πραγματοποιήθηκε δίμηνη έρευνα σε έναν παιδικό σταθμό του Δήμου Ζωγράφου ανάμεσα σε 24 παιδιά ηλικίας 3 έως 5 ετών. Μέσω της μεθοδολογικής προσέγγισης της συμμετοχικής παρατήρησης, συγκεντρώθηκαν και διερευνήθηκαν περιπτώσεις-παραδείγματα τα οποία σχετίζονται με τη γνωστική ανάπτυξη, τη λεκτική συνεργασία, την κοινωνικοποίηση και το παιχνίδι ρόλων των παιδιών. Μέσα από τη μελέτη των εννοιών της καταστασιακής μάθησης και του παιχνιδιού επιχειρείται η σύνδεσή τους. Οι θεωρητικές και πρακτικές εφαρμογές της σύνδεσης αυτής συμβάλλουν στην περαιτέρω ανάλυση και κατανόηση των συγκεκριμένων περιπτώσεων-παραδειγμάτων/μοτίβων. Τα ευρήματα υποδεικνύουν ότι το παιχνίδι ως βασική δραστηριότητα μάθησης, λειτουργεί ως μέσο καταστασιακής μάθησης που υποστηρίζει τη γνωστική και κοινωνική εξέλιξη των παιδιών. Σκοπός της εργασίας είναι να αναδειχθεί η σύνδεση της καταστασιακής μάθησης με το παιχνίδι προκειμένου να κατανοηθεί και να ενισχυθεί η αναπτυξιακή δραστηριότητα των παιδιών προσχολικής ηλικίας.
Effects of polyisoprenoids from Avicennia lanata and Avicennia alba leaves on the gene expression of PI3K, Akt1, mTOR, P53, and EGFR in human colorectal adenocarcinoma WiDr cells using reverse transcription-PCR
Authors: Qurrohman Taufiq , Hasibuan Poppy Anjelisa Zaitun , Nuryawan Arif , Sumaiyah Sumaiyah , Siregar Etti Sartina , Basyuni Mohammad 
Published: March 2020

Background:Mangrove plants produce a polyisoprenoid compound. Polyisoprenoids have been proven to have anticancer properties. This study investigated the inhibitory activity of polyisoprenoids derived from the leaves of mangrove plantsAvicennia albaandAvicennia lanataregarding the expression of PI3K, Akt1, mTOR, P53, and EGFR genes against human colorectal adenocarcinoma WiDr cells.Methods:Anticancer activity was tested through the MTT assay method performed on WiDr cells. The inhibited cell cycle and apoptosis were analysed by flow cytometry and double staining. Gene expression of PI3K, Akt1, mTOR, P53, and EGFR was observed using the RT-PCR method.Results:Cytotoxic activity against WiDr cells showed that the IC50 forA. albaandA. lanatawas 258.14 ug/mL and 243.32 ug/mL, respectively. This indicated that their classification as anticancer agents was moderate. The cell cycle showed that inhibition ofA. albaandA. lanataoccurred in the late phase of apoptosis S (10.60 and 10.51%) and G2-M1 (22.05 and 23.84%), which was higher than negative and positive control cells. Furthermore, the polyisoprenoids derived fromA. albaandA. lanataleaves exhibited anticancer activity in WiDr cells through the downregulated gene expression of PI3K, Akt1, mTOR, and EGFR as well as the upregulated gene expression of P53.Conclusion:This study demonstrated that polyisoprenoids obtained fromA. albaandA. lanataleaves are promising chemopreventive agents for colon cancer.
Constrained Load-Balancing Policies for Parallel Single-Server Queue Systems
Authors: Do Hung T. , Shunko Masha 
Published: March 2020

Flow-control policies that balance server loads are well known for improving performance of queueing systems with multiple nodes. However, although load balancing benefits the system overall, it may negatively impact some of the queueing nodes. For example, it may reduce throughput rates or engender unfairness with respect to some performance measures. For queueing systems with multiple single-server nodes, we propose a set of constrained load-balancing policies that ensures the expected arrival rate to each queueing node is not reduced, and we show that such policies provide multiple benefits for each queueing node: stochastically fewer customers and lower variance of the number of customers at each queueing node. These results imply performance improvement as measured by multiple general objective functions, including but not limited to the expected number of customers at a queueing node, probability of having a high number of customers, variance of the number of customers, and expected number of customers conditional on exceeding a threshold defined by a fixed service level. We demonstrate numerically that our proposed policies capture a large portion of the potential maximal improvement. This paper was accepted by Noah Gans, stochastic models and simulation.
Diaphragm disease in emergency surgery
Authors: Sarma Diwakar R , Bhattacharya Pratik 
Published: March 2020

Background/Aims Diaphragm disease of the small bowel has been described in the literature over the last three decades. The pathognomonic characteristic of multiple circumferential stenosis is noted on gross examination of the bowel. It is a severe form of non-steroidal anti-inflammatory drug-induced enteropathy, often presenting as acute small bowel obstruction. A systematic review was performed to identify risk factors and patient outcomes in histologically-proven diaphragm disease of the small intestine in patients undergoing emergency operation for small bowel obstruction. Methods A comprehensive search was performed between January 1975 and March 2019 using relevant MeSH terms. Studies were chosen based on predefined inclusion criteria. Diaphragm disease of the small intestine was defined as macroscopically detected thin diaphragm-like mucosal folding inside the lumen of the bowel. The parameters assessed included patient characteristics, duration of use of non-steroidal anti-inflammatory drugs, type of emergency surgery performed, complications, recurrence, presentation and diagnosis of diaphragm disease. Results A total of 21 studies were analysed which included 17 case reports, one case series, and three retrospective comparative studies. Overall 29 patients with diaphragm disease of the small bowel were reported following emergency laparotomy for small bowel obstruction. Use of non-steroidal anti-inflammatory drugs was noted in all cases with an average duration of 3–5 years. All patients presented acutely with features of small bowel obstruction and had emergency laparotomy, except one who underwent laparoscopic resection. In the comparative studies patients were more likely to be female and to have been taking non-steroidal anti-inflammatory drugs for more than 7 years. Conclusions This is a rare disease, difficult to diagnose and often confirmed by the intra-operative macroscopic appearance of circumferential stenosis of the bowel. Risk factors for developing small bowel diaphragm disease include long-term use of non-steroidal anti-inflammatory drugs, and female gender. Patients with this disease are at increased risk of developing acute small bowel obstruction, so early identification is important.
Libro: Aprendizaje y enseñanza de las matemáticas
Authors: Beltrán-Pellicer Pablo 
Published: March 2020

Reseña de:Arce Sánchez, M., Conejo Garrote, L., y Muñoz Escolano, J.M. (2019). Aprendizaje y enseñanza de las matemáticas. Madrid: Editorial Síntesis.