bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of baseline kidney disease with outcomes of transcatheter mitral valve repair by MitraClip
Authors: Raheja Hitesh , Ahuja Keerat Rai , Nazir Salik , Saad Anas M. , Gad Mohamed M. , Chatterjee Saurav , Abdelfattah Omar M. , Hassanein Mohamed , Harb Serge , Kapadia Samir R. 
Published: July 2020

AbstractObjectivesThis study sought to determine the impact of baseline chronic kidney disease (CKD) on in‐hospital outcomes of transcatheter mitral valve repair with MitraClip (MC).BackgroundMC is now an established treatment in high surgical risk patients. However, limited data are available on outcomes of MC in patients with baseline renal dysfunction.MethodsThe authors used data from January 2014 to December 2017 National Readmission Database to identify all patients ≥18 years of age who underwent MC. International classification of diseases (ICD)‐9 and ICD‐10 codes were used to identify patients with no‐CKD, CKD (without chronic dialysis), or end‐stage renal disease (ESRD) on dialysis. Multivariable logistic regression models were constructed using generalized estimating equations to examine in‐hospital outcomes.ResultsOf 13,563 patients undergoing MC, 8,935 (65.8%) had no‐CKD, 4,152 (30.6%) had CKD, and 476 (3.5%) had ESRD. ESRD patients compared to CKD and no‐CKD had significantly higher mortality (7.2% vs. 2.5% vs. 2.0%; p < .001), higher incidence of bleeding, blood transfusions, and 30 day all cause readmission. CKD patients compared to no‐CKD had significantly higher mortality (odds ratio‐1.29; CI 1.01–1.65; p = .04), acute kidney injury (odds ratio‐3.0; CI 2.69–3.34; p < .001), new in‐hospital hemodialysis (odds ratio‐ 2.70; CI 1.57–4.62; p < .001), blood transfusions, 30 day all cause and congestive heart failure (CHF) readmissions. In‐hospital stroke and cardiac tamponade did not differ between the three groups. Patients with baseline kidney disease undergoing MC had higher mortality at high volume centers compared to low volume centers. CHF was the most common cause of readmission postMC in patients with or without preprocedural kidney disease.ConclusionPatients with baseline kidney disease have worse outcomes after MC with higher readmission rates requiring careful patient selection and follow up in this population.
Development of quality protein product using biofortified maize to combat malnutrition among young children
Authors: Grover Kiran , Arora Shobita , Choudhary Monika 
Published: July 2020

AbstractBackground and objectivesProtein–energy malnutrition is the most prevalent nutrient deficiency across the world predominantly affecting young children. The present study was undertaken to develop quality protein maize (QPM)‐based biscuits for its supplementation to 60 malnourished young children (aged between 4 and 6 years). The developed biscuits were analyzed for nutritional composition, and the effect of supplementation was determined by evaluating the overall nutritional status of the subjects.FindingsThe nutritional analysis revealed that QPM‐based biscuits contained 8.1 g/day crude protein, 0.8 g tryptophan, 1.6 g methionine, and 3.6 g lysine per 100 g. The evaluation of nutritional status of the subjects revealed that the blood levels of total protein in the subjects of both groups were at par with the standard value (6.6 g/dl) before and after supplementation.ConclusionsA percentage of total anemic subjects (63.3%) in the experimental group significantly (p ≤ .01) reduced to 16.6 percent, and the prevalence of severe underweight (≥3 SD) (23.34%) reduced to zero after supplementation with QPM‐based biscuits.Significance and noveltyThis study opens prospects for the bakery industry to develop low‐cost quality protein products which may further be recommended to the supplementation programs engaged to curb malnutrition in the developing countries.
Cardiovascular patients in COVID‐19 era, a case series, an experience from a tertiary cardiovascular center in Tehran, Iran
Authors: Naderi Nasim , Ansari Ramandi Mohammad Mostafa , Baay Mohammadreza , Hosseini Zahra , Zanganehfar Mohammad Esmaeil , Rabieie Parham , Kamali Monireh , Manshouri Shirin , Moradnejad Pardis , Asadian Sanaz 
Published: July 2020

AbstractDifferent cardiovascular presentations of coronavirus disease 2019 can be seen because of the systemic involvement. Considering its new presentations, there is need for further studies regarding the mechanistic pathways involved.
Highly Specific Recognition of Guanosine Using Engineered Base‐Excised Aptamers
Authors: Li Yuqing , Liu Juewen 
Published: July 2020

AbstractPurines and their derivatives are highly important molecules in biology for nucleic acid synthesis, energy storage, and signaling. Although many DNA aptamers have been obtained for binding adenine derivatives such as adenosine, adenosine monophosphate, and adenosine triphosphate, success for the specific binding of guanosine has been limited. Instead of performing new aptamer selections, we report herein a base‐excision strategy to engineer existing aptamers to bind guanosine. Both a Na+‐binding aptamer and the classical adenosine aptamer have been manipulated as base‐excising scaffolds. A total of seven guanosine aptamers were designed, of which the G16‐deleted Na+ aptamer showed the highest bindng specificity and affinity for guanosine with an apparent dissociation constant of 0.78 mm. Single monophosphate difference in the target molecule was also recognizable. The generality of both the aptamer scaffold and excised site were systematically studied. Overall, this work provides a few guanosine binding aptamers by using a non‐SELEX method. It also provides deeper insights into the engineering of aptamers for molecular recognition.
Structural Design and Synthesis of an SnO2@C@Co‐NC Composite as a High‐Performance Anode Material for Lithium‐Ion Batteries
Authors: Li Qiongguang , Wang Yanhong , Tan Qiangqiang , Zhong Ziyi , Su Fabing 
Published: July 2020

AbstractTo overcome the drawbacks of the structural instability and poor conductivity of SnO2‐based anode materials, a hollow core–shell‐structured SnO2@C@Co‐NC (NC=N‐doped carbon) composite was designed and synthesized by employing the heteroatom‐doping and multiconfinement strategies. This composite material showed a much‐reduced resistance to charge transfer and excellent cycling performance compared to the bare SnO2 nanoparticles and SnO2@C composites. The doped heteroatoms and heterostructure boost the charge transfer, and the porous structure shortens the Li‐ion diffusion pathway. Also, the volume expansion of SnO2 NPs is accommodated by the hollow space and restricted by the multishell heteroatom‐doped carbon framework. As a result, this structured anode material delivered a high initial capacity of 1559.1 mA h g−1 at 50 mA g−1 and an initial charge capacity of 627.2 mA h g−1 at 500 mA g−1. Moreover, the discharge capacity could be maintained at 410.8 mA h g−1 after 500 cycles with an attenuation rate of only 0.069 % per cycle. This multiconfined SnO2@C@Co‐NC structure with superior energy density and durable lifespan is highly promising for the next‐generation lithium‐ion batteries.
Triphenylamine/Tetracyanobutadiene‐Based π‐Conjugated Push–Pull Molecules End‐Capped with Arene Platforms: Synthesis, Photophysics, and Photovoltaic Response
Authors: Simón Marqués Pablo , Castán José María Andrés , Raul Benedito A. L. , Londi Giacomo , Ramirez Ivan , Pshenichnikov Maxim S. , Beljonne David , Walzer Karsten , Blais Martin , Allain Magali , Cabanetos Clément , Blanchard Philippe 
Published: July 2020

Abstractπ‐Conjugated push–pull molecules based on triphenylamine and 1,1,4,4‐tetracyanobuta‐1,3‐diene (TCBD) have been functionalized with different terminal arene units. In solution, these highly TCBD‐twisted systems showed a strong internal charge transfer band in the visible spectrum and no detectable photoluminescence (PL). Photophysical and theoretical investigations revealed very short singlet excited state deactivation time of ≈10 ps resulting from significant conformational changes of the TCBD‐arene moiety upon photoexcitation, opening a pathway for non‐radiative decay. The PL was recovered in vacuum‐processed films or when the molecules were dispersed in a PMMA matrix leading to a significant increase of the excited state deactivation time. As shown by cyclic voltammetry, these molecules can act as electron donors compared to C60. Hence, vacuum‐processed planar heterojunction organic solar cells were fabricated leading to a maximum power conversion efficiency of ca. 1.9 % which decreases with the increase of the arene size.
Enhanced Electrocatalytic Activity of a Zinc Porphyrin for CO2 Reduction: Cooperative Effects of Triazole Units in the Second Coordination Sphere
Authors: Lashgari Amir , Williams Caroline K. , Glover Jenna L. , Wu Yueshen , Chai Jingchao , Jiang Jianbing “Jimmy” 
Published: July 2020

AbstractThe control of the second coordination sphere in a coordination complex plays an important role in improving catalytic efficiency. Herein, we report a zinc porphyrin complex ZnPor8T with multiple flexible triazole units comprising the second coordination sphere, as an electrocatalyst for the highly selective electrochemical reduction of carbon dioxide (CO2) to carbon monoxide (CO). This electrocatalyst converted CO2 to CO with a Faradaic efficiency of 99 % and a current density of −6.2 mA cm−2 at −2.4 V vs. Fc/Fc+ in N,N‐dimethylformamide using water as the proton source. Structure‐function relationship studies were carried out on ZnPor8T analogs containing different numbers of triazole units and distinct triazole geometries; these unveiled that the triazole units function cooperatively to stabilize the CO2‐catalyst adduct in order to facilitate intramolecular proton transfer. Our findings demonstrate that incorporating triazole units that function in a cooperative manner is a versatile strategy to enhance the activity of electrocatalytic CO2 conversion.
Künstliche Photosynthese
Authors: Weitze Marc‐Denis , Tran David , Dau Holger , Kurz Philipp 
Published: July 2020

ZusammenfassungDie Künstliche Photosynthese kann einen wesentlichen Beitrag zum Gelingen einer nachhaltigen Energiewende leisten. Die einzelnen Schlüsselprozesse sind weitgehend erforscht und verstanden. Es gibt bereits einzelne Systeme, etwa basierend auf einer Kombination aus Elektrolyse und Photovoltaik, in denen durch Sonnenenergie Wasser und Kohlendioxid in Brenn‐ und Rohstoffe umgewandelt werden. Als konsequente Weiterentwicklung von Power‐to‐X‐Technologien kann durch Künstliche Photosynthese Sonnenergie noch am selben Ort zur Produktion von Brenn‐ und Wertstoffen genutzt und so der Umweg über das Stromnetz vermieden werden. Wichtig ist, dass die Gesellschaft durch einen intensiven Dialog im frühen Entwicklungsstadium für neue Technologien sensibilisiert wird. Nur so kann die Weiterentwicklung der Künstlichen Photosynthese nachhaltig vorangetrieben werden.
Iron recovery from zinc mine tailings by magnetic separation followed by carbothermal reduction of self‐reducing briquettes
Authors: Tenório Vinhal Jonathan , Húngaro Costa Raquel , Luís Coleti Jorge , Espinosa Denise C. R. 
Published: July 2020

AbstractThe volume of tailings produced by the extractive industry has been increasing due to the processing of the low‐grade ore. This issue can cause environmental accidents and require significant investment to control the disposal of tailings. Therefore, this study aims to recover iron from zinc mine tailings by wet magnetic separation followed by the carbothermal reduction of self‐reducing briquettes. Two magnetic separation routes were investigated to concentrate iron. Zinc mine tailings were processed by route I, in a rougher stage followed by a scavenger stage; and route II, in a rougher stage followed by a cleaner stage. The carbothermal reductions were performed using self‐reducing briquettes composed of Fe concentrate from the route with high Fe content and charcoal. The products were analyzed by scanning electron microscopy with energy dispersive spectroscopy (SEM‐EDS), x‐ray diffraction (XRD), inductively coupled plasma optical emission spectrometry (ICP‐OES), and volumetric chemical analysis. Magnetic separation route II provided the highest‐grade Fe concentrate, 52% Fe, while route I provided 33% Fe. In the carbothermal reductions, a metallization degree of 98% in the Fe concentrate briquette, 97% in the briquette with a 10% replacement of its raw material by Fe concentrate, and 99% in the hematite briquette was reached. The replacement of raw material by Fe concentrate showed no significant change in Fe recovery. Considering the whole process, magnetic separation and carbothermal reduction, the recovery of Fe from the zinc mine tailings was 67%. Therefore, the process route suggested in this study will not only reduce tailings disposal and consequently the risk of environmental accidents, but it will also provide profitable raw material for the steel industry.
Manganese‐Catalyzed Hydrocarbofunctionalization of Internal Alkenes†
Authors: Wang Dongping , He Yijie , Dai Haotian , Huang Congcong , Yuan Xiang‐Ai , Xie Jin 
Published: July 2020

Summary of main observation and conclusionA highly regio‐ and chemo‐selective dimeric Mn(I)‐catalyzed hydroarylation and hydroalkenylation of unbiased internal alkenes with commercially abundant organoboron compounds is reported. A wide range of densely functionalized aliphatic alkenyl amides can successfully undergo site‐exclusive hydrocarbofunctionalization in air atmosphere without any exogenous directing auxiliary, affording an enhanced lead library of structurally diverse γ‐functionalized carboxylic acid derivatives in moderate to good yields. The precise chemoselectivity of the reaction among multiple alkene units even in the presence of reactive terminal alkenes highlights the unique catalytic features of manganese catalyst, and the excellent functional group compatibility of primary amides further complements other transition metals.
Targeting SARS‐CoV‐2 RBD Interface: a Supervised Computational Data‐Driven Approach to Identify Potential Modulators
Authors: Gulotta Maria Rita , Lombino Jessica , Perricone Ugo , De Simone Giada , Mekni Nedra , De Rosa Maria , Diana Patrizia , Padova Alessandro 
Published: July 2020

AbstractCoronavirus disease 2019 (COVID‐19) has spread out as a pandemic threat affecting over 2 million people. The infectious process initiates via binding of SARS‐CoV‐2 Spike (S) glycoprotein to host angiotensin‐converting enzyme 2 (ACE2). The interaction is mediated by the receptor‐binding domain (RBD) of S glycoprotein, promoting host receptor recognition and binding to ACE2 peptidase domain (PD), thus representing a promising target for therapeutic intervention. Herein, we present a computational study aimed at identifying small molecules potentially able to target RBD. Although targeting PPI remains a challenge in drug discovery, our investigation highlights that interaction between SARS‐CoV‐2 RBD and ACE2 PD might be prone to small molecule modulation, due to the hydrophilic nature of the bi‐molecular recognition process and the presence of druggable hot spots. The fundamental objective is to identify, and provide to the international scientific community, hit molecules potentially suitable to enter the drug discovery process, preclinical validation and development.
7‐Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation
Authors: Rodríguez‐Enríquez Fernanda , Viña Dolores , Uriarte Eugenio , Laguna Reyes , Matos Maria J. 
Published: July 2020

AbstractThis study explores the potential of 7‐amidocoumarins as multitarget agents against Parkinson's and Alzheimer's diseases, by modulating the substitution patterns within the scaffold. Sixteen compounds were synthesized via 7‐amino‐4‐methylcoumarin acylation, and in vitro evaluation of the molecules against hMAO‐A, hMAO‐B, hAChE, hBuChE and hBACE1 was performed. Five compounds turned out to be potent and selective hMAO‐B inhibitors in the nanomolar range, six displayed inhibitory activity of hMAO‐A in the low micromolar range, one showed hAChE inhibitory activity and another one hBACE1 inhibitory activity. MAO‐B reversibility profile of 7‐(4’‐chlorobenzamido)‐4‐methylcoumarin (10) was investigated, with this compound being a reversible inhibitor. Neurotoxicity on motor cortex neurons and neuroprotection against H2O2 were also studied, corroborating the safety profile of these molecules. Finally, theoretical ADME properties were also calculated, showing these molecules as good candidates for the optimization of a lead compound. Results suggest that by modulating the substitution pattern at position 7 of the scaffold, selective or multitarget molecules can be achieved.
Assessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants
Authors: Adedoyin Adedayo , Fancourt Craig , Menzel Karsten , Zhao Tian , Tomek Charles , Panebianco Deborah , McCrea Jacqueline B. , Stoch S. Aubrey , Iwamoto Marian 
Published: July 2020

AbstractLetermovir is a prophylactic agent for cytomegalovirus infection and disease in adult cytomegalovirus‐seropositive recipients of allogeneic hematopoietic stem cell transplant. As the antifungal agent fluconazole is administered frequently in transplant recipients, a drug–drug interaction study was conducted between oral letermovir and oral fluconazole. A phase 1 open‐label, fixed‐sequence study was performed in healthy females (N = 14, 19‐55 years). In Period 1, a single dose of fluconazole 400 mg was administered. Following a 14‐day washout, a single dose of letermovir 480 mg was administered (Period 2), and after a 7‐day washout, single doses of fluconazole 400 mg and letermovir 480 mg were coadministered in Period 3. Pharmacokinetics and safety were evaluated. The pharmacokinetics of fluconazole and letermovir were not meaningfully changed following coadministration. Fluconazole geometric mean ratio (GMR; 90% confidence interval [CI]) with letermovir for area under the concentration‐versus‐time curve from time 0 to infinity (AUC0‐∞) was 1.03 (0.99‐1.08); maximum concentration (Cmax) was 0.95 (0.92‐0.99). Letermovir AUC0‐∞ GMR (90%CI) was 1.11 (1.01‐1.23), and Cmax was 1.06 (0.93‐1.21) following coadministration with fluconazole. Coadministration of fluconazole and letermovir was generally well tolerated.
Detection of structure query language injection vulnerability in web driven database application
Authors: Aliero Muhammad Saidu , Qureshi Kashif Naseer , Pasha Muhammad Fermi , Ahmad Awais , Jeon Gwanggil 
Published: July 2020

SummaryStructure Query Language Injection Attack is among the top 10‐security threats that can be used on the web application to cause severe damage or gain unauthorized data access to the application server. Many reports have indicated an average of 64% of global websites are at risk of being attack by SQL injection, and many of the top companies have experienced thousands of attacks attempts through SQL injection. The current trend shows the increasing number of attacks factor as a result of the daily deployment of these applications without security detection and prevention mechanism is placed. To overcome this challenge, researches in academia and industry presented a proposal that automates SQL injection vulnerabilities assessment on the tested application. Current studies show the need to enhance techniques of these proposals to reduce the false alarms. In this study, we propose a component‐based technique to minimize the incidence of inaccurate results, as well as enable the ease of improving the proposed solution. The study uses three costumed applications as tested to evaluate the accuracy of the proposed solution. Each of these testbed consists of several vulnerabilities where the experimental evaluation performs to test the proposed tool. An empirical evaluation is carried out on three vulnerable custom websites to evaluate the effectiveness of the proposed study. The experiment results indicated significant results in terms of high accuracy. On the other hand, the proposed solution also has better capabilities to analyze page response based on four different techniques. Moreover, the proposed solution is the only solution that performs stored procedure attacks SQL and bypass login authentication even if the returned records are limited restriction is applied.
Quantification of Neutrophil Extracellular Traps Isolated From Mouse Tissues
Authors: Buckland Rebecca L. , Wilson Alicia S. , Brüstle Anne 
Published: July 2020

AbstractOne of the most intriguing functions of neutrophils is the production of neutrophil extracellular traps (NETs), which are formed when neutrophils decondense their internal DNA and extrude it along with cytotoxic proteins in a web‐like structure. This process allows neutrophils to trap and kill pathogens, and is also associated with multiple hematological and autoimmune conditions. Due to their rapid degradation, there are many challenges in accurately and specifically detecting and quantifying NETs. Microscopy is the gold standard for NET detection, but is not optimal for large‐scale screening. Furthermore, methods relying on detection of free DNA or on flow cytometry–based examination of NET‐associated markers can be nonspecific, time‐consuming, and expensive. Here, we describe an innovative, quick, specific, and inexpensive conventional flow cytometry method for detecting neutrophils on the verge of forming NETs. These methods utilize pulse‐shaped analysis (PulSA) to distinguish resting neutrophils from those with decondensed DNA, a prerequisite for NET formation. An increase in DNA‐diffuse neutrophils is found in cell populations after exposure to NET‐inducing stimuli, consistent with the DNA decondensation expected during neutrophil NET formation. These populations are only observed in granulocytes, validating the specificity of this method. We describe protocols optimized for neutrophils retrieved from mouse blood, spleen, and bone marrow. The relative speed and simplicity of the method described here makes it a useful tool for detecting NET formation in large‐scale experiments. © 2020 Wiley Periodicals LLC.Basic Protocol: Detection of nuclear decondensation in neutrophils from stimulated murine bone marrowAlternate Protocol 1: Detection of nuclear decondensation in neutrophils from splenocytesAlternate Protocol 2: Detection of nuclear decondensation in neutrophils from bloodSupport Protocol 1: Cryopreservation and defrosting of samplesSupport Protocol 2: Paraformaldehyde fixation of samples
Strategic corporate social responsibility, capabilities, and opportunities: Empirical substantiation and futuristic implications
Authors: Rameshwar Rudra , Saha Raiswa , Sanyal Shamindra Nath 
Published: July 2020

AbstractThe underlying principle of the present research work is to examine how manager's personal values and strategic CSR influences employees perceived CSR and implementation within their organizations, therefore, giving importance to the performance and sustainable development as a whole. Here, the research model is tested all the way through an assessment conferring with 238 survey participants from companies functioning in a variety of sectors like agribusiness, automobiles, and so forth. The end result guides to the subsequent conclusions: managers' personal values exhibited a direct positive relationship with both employees' CSR perception and CSR implementation; strategic CSR also displayed a positive relationship with both employees' CSR perception and CSR implementation. The analysis also shows an optimistic association between CSR implementation and CSR performance; whereas CSR performance demonstrated a significant positive relationship with corporate sustainable development, thereby, accepting the proposed hypothesis formulated. The CSR implementation has changed to be a vital constituent of management and organizational behavior. However, the internal CSR dimension has been principally mistreated so far. Hence, this is a bridging study between the micro aspect of perception leading to macro perspective of sustainability and performance system management which is a vital contribution of this paper.