bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clonal cytopenia of undetermined significance (CCUS) with dysplasia is enriched for MDS‐type molecular findings compared to CCUS without dysplasia
Authors: Jajosky Audrey N. , Sadri Navid , Meyerson Howard J. , Oduro Kwadwo A. , Kelkar Ashwin , Fitzgerald Brynn , Tomlinson Benjamin , Moore Erika M. , Beck Rose C. 
Published: January 2021

AbstractObjectivesAlthough morphologic dysplasia is not typically considered a feature of CCUS, we have consistently observed low‐level bone marrow (BM) dysplasia among CCUS patients. We sought to determine whether sub‐diagnostic BM dysplasia in CCUS patients is associated with other clinico‐pathologic findings of myelodysplastic syndrome (MDS).MethodsWe identified 49 CCUS patients, 25 with sub‐diagnostic dysplasia (CCUS‐D), and 24 having no dysplasia (CCUS‐ND). We compared the clinical, histologic, and laboratory findings of CCUS‐D and CCUS‐ND patients to 49 MDS patients, including blood cell counts, BM morphology, flow cytometry, cytogenetics, and results of next‐generation sequencing.ResultsNo statistically significant differences were observed between CCUS‐D and CCUS‐ND patients in the degree of cytopenias, BM cellularity, myeloid‐to‐erythroid ratio, or the presence of flow cytometric abnormalities. However, compared to CCUS‐ND, CCUS‐D patients exhibited increased mutations in myeloid malignancy‐associated genes, including non‐TET2/DNMT3A/ASXL1 variants, spliceosome (SF3B1, SRSF2, ZRSR2, or U2AF1) variants, and IDH2/RUNX1/CBL variants. CCUS‐D patients were also enriched for higher variant allele frequencies and co‐mutation of TET2/DNMT3A/ASXL1 with other genes.ConclusionsCCUS‐D patients exhibit a molecular (but not clinical) profile more similar to MDS patients than CCUS‐ND, suggesting CCUS‐D may represent a more immediate precursor to MDS and may warrant closer clinical follow‐up.
Barriers and Facilitators to integrate Oral Health care for Older Adults in General (Basic) Care in East Netherlands. Part 2 Functional Integration
Authors: Niesten D. , Gerritsen A.E. , Leve V. 
Published: January 2021

AbstractObjectiveto synthesise a framework of barriers and facilitators in the functional integration of oral health care (OHC) into general health care for frail older adults at macro (system), meso (organisation and interprofessional integration) and micro (clinical practice) levels.BackgroundIdentification of these barriers and facilitators is expected to promote better and more appropriate care.MethodsFor this qualitative study, comprising 41 participants, representatives of 10 different groups of (professional) care providers, and OHC receivers (home‐dwelling and nursing‐home patients) were interviewed. Transcripts of the in‐depth, topic‐guided interviews were thematically analysed. In a subsequent workshop with 52 stakeholders, results and interpretations were discussed and refined.ResultsTwo themes were identified: (1) compartmentalised care systems and (2) poor interprofessional and communication infrastructure. Barriers related to (1) included lack of integrative policies and compartmentalised healthcare education (macro level); poor embedding of OHC in care procedures, instruments and guidelines (meso level); and poor interprofessional skills (micro level). Barriers related to (2) included poor financial incentives for collaborative practices (macro level) and badly connected ICT systems (meso level). Identified facilitators included integration of an OHC professional into care teams, and interdisciplinary consultations (meso level); and integration of OHC in individual care plans (micro level).ConclusionIn The Netherlands, OHC for older people is at best poorly integrated into general care practices. Barriers and facilitators are interconnected across macro‐, meso‐ and micro levels and between normative and functional domains and are mainly related to compartmentalisation at all levels and to poor interprofessional and communication infrastructure.
Management of portal hypertension based on portal hemodynamics
Authors: Yoshida Hiroshi , Shimizu Tetsuya , Yoshioka Masato , Taniai Nobuhiko 
Published: January 2021

AbstractPortal hypertension is most commonly caused by chronic liver disease. As liver damage progresses, portal pressure gradually elevates and hemodynamics of the portal system gradually change. In normal liver, venous returns from visceral organs join the portal trunk and flow into the liver (hepatopetal blood flow). As portal pressure increases due to liver damage, congestion of some veins of the visceral organ occurs (blood flow to and from). Finally, the direction of some veins (the left gastric vein in particular) of the visceral organ change (hepatofugal blood flow) and develop as collateral veins (portosystemic shunt) to reduce portal pressure. Therefore, esophagogastric varices serve as drainage veins for the portal venous system to reduce the portal pressure. In chronic liver disease, as intrahepatic vascular resistance is increased (backward flow theory) and collateral veins develop, adequate portal hypertension is required to maintain portal flow into the liver through an increase of blood flow into the portal venous system (forward flow theory). Splanchnic and systemic arterial vasodilatations increase the blood flow into the portal venous system (hyperdynamic state) and lead to portal hypertension and collateral formation. Hyperdynamic state, especially around the spleen, is detected in patients with portal hypertension. The spleen is a regulatory organ that maintains portal flow into the liver. In this review, surgical treatment, interventional radiology, endoscopic treatment, and pharmacotherapy for portal hypertension (esophagogastric varices in particular) are described based on the portal hemodynamics using schema.
Correlation of methylthioadenosine phosphorylase (MTAP) protein expression with MTAP and CDKN2A copy number in malignant pleural mesothelioma
Authors: Chapel David B , Dubuc Adrian M , Hornick Jason L , Sholl Lynette M 
Published: January 2021

AimsMethylthioadenosine phosphorylase (MTAP) immunohistochemical expression is a specific marker of CDKN2A deletion in malignant mesothelioma. However, the relationship of MTAP expression with MTAP copy number remains unexplored.Methods and resultsForty malignant pleural mesotheliomas were characterised by targeted next‐generation sequencing (29), single‐nucleotide polymorphism microarray (seven), or both (four). MTAP and CDKN2A copy numbers were correlated with MTAP expression. Twenty‐seven (68%) tumours showed CDKN2A deletion (14 heterozygous; 13 homozygous), of which 20 (74%) showed MTAP codeletion (15 heterozygous; five homozygous). No tumours showed MTAP deletion without CDKN2A codeletion. Loss of MTAP expression was seen in 16 (40%) tumours, and was 75% sensitive and 95% specific for MTAP deletion, and 59% sensitive and 100% specific for CDKN2A deletion. Nine of 40 (23%) tumours showed heterogeneous MTAP staining, and the percentage of tumour cells with MTAP loss correlated with molecular detection of MTAP deletion.ConclusionsMTAP is frequently codeleted with CDKN2A in pleural mesothelioma. However, homozygous deletion of both genes occurs in a minority of tumours (5/40; 13%); CDKN2A deletion often co‐occurs with heterozygous MTAP deletion or neutral MTAP copy number; and MTAP expression correlates inconsistently with heterozygous MTAP deletion. Correspondingly, MTAP immunohistochemistry is a highly specific but only moderately sensitive assay for CDKN2A deletion.
Two‐step preparation of fly ash‐based composites for microwave absorption
Authors: Zhu Baoshun , Tian Yuming , Liang Liping , Wang Yake , Mao Lutao , Gao Fei , Zhang Kewei , Li Guomin 
Published: January 2021

AbstractTo develop a novel utilization avenue for fly ash (FA), the Co‐loaded FA (CoFA) was constructed utilizing FA as raw material to acquire the enhanced microwave absorption (MA) performance. In this study, the CoFA composites were fabricated by a two‐step method, including the construction of FA‐based ceramic matrix and a subsequent loading of magnetic components. The results of XRD, SEM, and elemental mapping images revealed that Co particles generated from the carbothermal reduction were well dispersed over the interior and surface of matrix. Compared with pure FA, the as‐prepared CoFA composites demonstrated the impressive MA performances, which were attributed to the good impedance matching, conduction loss, and interfacial polarization effect between the matrix and Co. When the annealing temperature kept at 700°C, the minimum reflection loss (RLmin) of as‐prepared CoFA700 reached up to −40.5 dB and the broad absorption band was measured to be 4.7 GHz with a thickness of 2.0 mm, which was superior to pure FA. Our strategy might provide a new direction to the fabrication of high‐efficient MA materials derived from FA.
Thermal shock and thermal fatigue resistance of Al2O3/(W, Ti)C/TiN/Mo/Ni multidimensional graded ceramics
Authors: Ni Xiuying , Zhao Jun , Gong Feng , Li Gang 
Published: January 2021

AbstractAl2O3/(W, Ti)C/TiN/Mo/Ni multidimensional graded ceramics and homogeneous reference ceramic were prepared by two step hot press sintering. The thermal shock and thermal fatigue resistance of the multidimensional graded ceramics were tested using the water quenching method. Scanning electron microscopy (SEM) and optical microscope were used to investigate microscopic failure mechanism of ceramics. The results showed that the retained flexural strength of two‐dimensional and one‐dimensional graded ceramics was almost same, but higher than that of the homogeneous ceramic. The crack growth (∆c) of homogeneous ceramic increased rapidly, while that of two‐dimensional graded ceramics is the lowest. Hence, thermal fatigue resistance of the two‐dimensional graded ceramics was highest. The residual compressive stress in the first layer induced by the optimal graded structure played an important role. In addition, the increasing toughness on the crack propagation path by adding different amounts of metals was also a contributing factor.
Electro‐optical performances of nanostructured SrTiOx films: The effect of plasma power, Ar/O2 ratio and annealing
Authors: Goldenberg Eda , Bayrak Turkan , Mohammadmoradi Omid 
Published: January 2021

AbstractThe present work evaluates the effects of plasma power and oxygen mixing ratios (OMRs) on structural, morphological, optical, and electrical properties of strontium titanate SrTiOx (STO) thin films. STO thin films were grown by magnetron sputtering, and later thermal annealing at 700°C for 1 h was applied to improve film properties. X‐ray diffraction analysis indicated that as‐deposited films have amorphous microstructure independent of deposition conditions. The films deposited at higher OMR values and later annealed also showed amorphous structure while the films deposited at lower OMR value and annealed have nanocrystallinity. In addition, all as‐deposited films were highly transparent (~80%–85%) in the visible spectrum and exhibited well‐defined main absorption edge, while the annealing improved transparency (90%) within the same spectrum. The calculated direct and indirect optical band gaps for films were in the range of 3.60‐4.30 eV as a function of deposition conditions. The refractive index of the films increased with OMRs and the postdeposition annealing. The frequency dependent capacitance measurements at 100 kHz were performed to obtain film dielectric constant values. High dielectric constant values reaching up to 100 were obtained. All STO samples exhibited more than 2.5 μC/cm2 charge storage capacity and low dielectric loss (less than 0.07 at 100 kHz). The leakage current density was relatively low (3 × 10−8Acm−2 at +0.8 V) indicating that STO films are promising for future dynamic random access memory applications.
Radiosensitization induced by zinc‐doped hydroxyapatite nanoparticles in breast cancer cells
Authors: Yedekci Yagiz , Gedik Emre , Evis Zafer , Dogan Lale , Özyigit Gökhan , Gürkaynak Murat 
Published: January 2021

AbstractZinc‐doped hydroxyapatite (HA) nanoparticles were synthesized by microwave assisted method and used with ionizing radiation for inhibition of proliferation of breast cancer cells. Zinc‐doped HAs were produced in four different compositions in order to determine the best doping rate in terms of physical and biological properties. Nanoparticle characterizations were performed with X‐ray diffractometer, Fourier transform infrared spectroscopy, scanning electron microscopy, and inductively coupled plasma‐mass spectrometry. Viability of MDA‐MB‐231(isolated at M D Anderson from a pleural effusion of a patient with invasive ductal carcinoma) cells treated with nano‐HA particles and radiation were assessed by MTT assay. Caspase‐7 and Poly (ADP‐ribose) polymerase protein expressions in samples were examined by the Western blot. X‐ray diffraction patterns of our samples were found to be in good correlation with the reference HA peaks. Notably, increasing zinc amount resulted in elevated percentage of β‐tricalcium phosphate, phases. All formulations including pure HA particles were non‐cytotoxic in MDA MB 231 cells. On the other hand, low rate Zn‐doped HA particles showed significant anti‐proliferation effect during irradiation. The combination of irradiation with Zn‐doped HA particles also induced apoptosis, demonstrated as cleavage of caspase‐7 and PARP proteins. In conclusion, low rate Zn‐doped HA enhanced the radiation effect on breast cancer cells.
Admission control of hospitalization with patient gender by using Markov decision process
Authors: Jiang Yanping , Yang Feifei , Tang Zhenpeng , Li Quan‐Lin 
Published: January 2021

AbstractAdmission control of hospitalization considering patient gender is an interesting issue in the study of hospital bed management. This paper addresses the decision on the admission of patients who should immediately be admitted into a same‐gender room or rejected. Note that a patient is admitted depending on different conditions, such as his/her health condition, gender, the availability of beds, the length of stay, and the reward of hospitalization. Focusing on the key factor, patient gender, this paper sets up an infinite‐horizon total discounted reward Markov decision process model with the purpose to maximize the total expected reward for the hospital, which leads to an optimal dynamic policy. Then, the structural properties of the optimal policy are analyzed. Additionally, a value iteration algorithm is proposed to find the optimal policy. Finally, some numerical experiments are used to discuss how the optimal dynamic policy depends on some key parameters of the system. Furthermore, the performance of the optimal policy is discussed though comparison with the three other policies by means of simulating different scenarios.
High lumen density of Al2O3‐LuAG: Ce composite ceramic for high‐brightness display
Authors: Zhang Qi , Zheng Ruilin , Ding Jianyong , Cui Peng , Wang Zhongyue , Lv Peng , Wei Wei 
Published: January 2021

AbstractThermally robust and highly efficient green‐emitting luminescent ceramics are gradually attracting great attention as promising phosphors using in high‐brightness laser phosphor display to reduce serious speckle noise as well as high cost. However, lumen density is still seriously restricting their potential applications especially under high‐power density laser due to insufficient absorption of blue laser and significant thermal quenching. Here, we report an Al2O3‐LuAG: Ce composite ceramic phosphor (CCP) for high‐brightness laser phosphor display. Owing to good optical properties and high thermal conductivity of Al2O3, the Al2O3‐LuAG: Ce CCP shows high photoluminescence quantum yield (79.6%), low thermal quenching (only 3.2% loss in luminescence at 200°C), and high thermal conductivity (18.9 W·m−1·K−1). Moreover, the Al2O3, as scattering centers, enhances the Rayleigh–Mie scattering of the blue laser, and hence the absorption of the Al2O3‐LuAG: Ce CCP exhibits a remarkable improvement (~2.3 times) at 450 nm. Finally, with optimized thickness (0.3 mm) of Al2O3‐LuAG: Ce CCP, an excellent luminous efficiency (216 lm·W−1) and outstanding lumen density (6129 lm·mm−2) of the green‐emitting light source was obtained by driving under a high‐power density (28.33 W·mm−2) blue laser. All of those validate the suitability of the Al2O3‐LuAG: Ce CCP for high‐brightness display.
Identification of 16p11.2 deletion syndrome on a child inpatient psychiatric unit: A case report and call for inpatient genetic testing
Authors: Gibbs William , Bell Harrison , Ajith Aniruddh , Sadtler Kim , Escuro Katrina , Brooks Deborah , Edwards Sarah 
Published: January 2021

AbstractPurposeThis case highlights the importance of nursing‐directed interprofessional treatment and inpatient unit genetic testing to identify genetic syndromes that may potentiate psychiatric conditions.Sources UsedA case study of a 10‐year‐old Caucasian male with a history of a congenital heart defect, hand malformation, and low academic functioning who was admitted to the child inpatient psychiatric unit for eloping from school, aggression, and possible psychotic symptoms. Data were collected using patient medical records and interprofessional evaluation from nursing, psychiatry, and occupational therapy.ResultsThe patient was treated with risperidone to manage psychotic symptoms. Dietary, occupational therapy, and scholastic plans were also implemented. After discharge, results of genetic microarray analysis revealed a Type 1 16p11.2 deletion.ConclusionThe role of nursing, interprofessional collaboration, and access to consultation teams play a crucial role in patient care for early diagnosis and treatment. Inpatient genetic testing has the potential to quickly identify and diagnose previously unidentified symptom clusters, leading to early intervention, closer monitoring, and improved patient outcomes.
Periodontitis is associated with cardiovascular diseases: A 13‐year study
Authors: Tiensripojamarn Niramol , Lertpimonchai Attawood , Tavedhikul Kanoknadda , Udomsak Artit , Vathesatogkit Prin , Sritara Piyamitr , Charatkulangkun Orawan 
Published: January 2021

AbstractAimTo prospectively evaluate the association between periodontitis and the incidence of cardiovascular diseases (CVDs) in Thai adults.Materials and methodsMedical data from the questionnaires and physical examinations of 1850 participants aged 47‒73 years from EGAT study were gathered. Random half‐mouth periodontal examination of each participant was performed by calibrated periodontists, and periodontal status was defined. The incidence of new CVD events, including coronary heart disease (CHD) and stroke, was verified by cardiologists. The Cox proportional hazard regression model was used to estimate hazard ratios (HRs).ResultsThe prevalence of no/mild, moderate and severe periodontitis in the study participants was 11.7%, 52.7% and 35.6%, respectively. During the 13‐year follow‐up, CVD events occurred in 110 (5.9%) participants, with 82 (4.4%) from CHD and 28 (1.5%) from stroke. After adjusting for cardiovascular risk factors, a significant association between severe periodontitis and the incidence of CHD was found compared with the no/mild periodontitis group with an HR of 4.53 (95% confidence intervals: 1.08‒19.02). However, no significant association was seen when considering total CVD events and stroke outcome.ConclusionsThis study demonstrates that severe periodontitis is associated with an increased incidence of CHD, independent of established cardiovascular risk factors.
The basis of information to guide clinical decision‐making in knee osteoarthritis management: A survey with Brazilian physical therapists
Authors: Monteiro Nívea Renata Oliveira , Pegorari Maycon Sousa , Ohara Daniela Gonçalves , Ferreira Vânia Tiê Koga , Matos Areolino Pena 
Published: January 2021

AbstractRationale, aims and objectivesSeveral health information sources are available to assist physical therapists in the clinical decision‐making process, with a notable increase in the importance of using evidence‐based practice (EBP). The aim of this study is to investigate the health information sources most used by Brazilian physical therapists to guide their clinical decision making for knee osteoarthritis (OA) management, use of Physiotherapy Evidence Database (PEDro), knowledge about the existence of clinical practice guidelines (CPGs), and associated factors.MethodsA cross‐sectional study using an electronic survey was conducted. Physical therapists registered in a Regional Physical Therapy Council in Brazil were invited to participate. Sociodemographic data, professional training, health information sources, frequency of use of PEDro, and knowledge about CPGs were collected. Descriptive analysis of the data was performed, and the chi square test and multinomial and binary logistic regression were used to verify association between the variables.ResultsThe survey was completed by 370 professionals. The three health information sources most used by Brazilian physical therapists were clinical experience, courses, and books. Among these professionals, only 12.1% use PEDro frequently, and 60.5% know that CPGs for knee OA management exist. Level of education was associated with PEDro use and knowledge about the existence of CPGs (P < .05).ConclusionsThe study results indicated a significant deficiency in engagement with research evidence by Brazilian physical therapists to guide their clinical decision making for knee OA. Further investigations on educational needs and the development of new strategies to narrow the gap between research evidence and clinical practice should be performed.
Financial clusters, industry groups, and stock return correlations
Authors: Fodor Andy , Jorgensen Randy D. , Stowe John D. 
Published: January 2021

AbstractIndustry classifications are used by investors, economists, and policy makers for a great variety of purposes. The traditional economic‐activity‐based systems (Global Industry Classification Standard, North American Industry Classification System, Standard Industrial Classification, and Fama–French) have been supplemented in recent years by alternative classification systems. Our purpose is to provide another alternative system that forms classification groups based on the structure of firm financial statements. Using cluster analysis, a multivariate tool that forms groups where their characteristics are similar within groups and distinct across groups, we form clusters of large U.S. firms based on their common‐size financial statements (percentage breakdowns of balance sheets and income statements). We characterize the financial clusters based on their industry classifications and other economic information and assess the ability of financial clusters and industry groups, separately and jointly, to explain stock return correlations of all pairs of firms. Our results demonstrate that using financial clusters and industry groups together proves advantageous relative to using either alone.