bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whale watching in Sri Lanka: Understanding the metadata of crowd-sourced photographs on FlickrTM social media platform
Authors: Bandara Tharindu , Bandara Tharanga Prageeth 
Published: November 2019

Data mining on social media platforms (Instagram™, Flickr™, and Twitter™) is rapidly increasing and application of data mining techniques has contributed to significant findings in various fields such as tourism, ecology, and politics etc. In the face of globalization and nature-based tourism is thriving in many countries, social media activity on tourism is increasing despite the socio-economical barriers. In this context, this paper attempts to understand the metadata of photographs related to whale watching in Sri Lanka in Flickr social media platform. Photographs related to whale watching was extracted and analyzed for i) photographic content ii) Geo-tags iii) Social-tags and iv) Photographers’ nationalities by using Flickr API (Application Programming Interface) and self-written python program script. Content analysis of the photographs has identified five major categories (human activity, accommodation, natural phenomena, animals and other) of photographs based on the major element present in each photograph. Mapping of geo-tagged photographs indicated that Mirissa was the hotspot for whale watching in Sri Lanka. Moreover, the present study suggests that mapping of geo-tagged photographs can be used as proxy data for whale distribution in Sri Lanka. Analysis of social tags indicated that tags indicating whale (156), Sri Lanka (144) and Mirissa (133) were popular among the photographers. The demographic profile of the photographers indicated that the highest number of photographers (25%) from the United Kingdom followed by Sri Lanka (18.69%) and China (12.94%) interested in whale watching. Despite some of the weaknesses, this study has demonstrated that metadata of Flickr photographs can effectively be used for understanding the basic information related to whale-watching tourism in Sri Lanka.
Diagnostic Upper Gastrointestinal Endoscopy and Prevalence of Helicobacter Pylori Infection in Dyspeptic Type 2 Diabetes Mellitus Patients
Authors: Vaishnav Bhumika T. , Shaikh Sameer R. , Bamanikar Arvind A. , Kakrani Arjun Lal , Tambile Rahul R. 
Published: November 2019

ABSTRACT
Introduction: Multisystem involvement is a norm in Type 2 diabetes mellitus (T2DM). Dyspepsia is a common gastrointestinal (GI) tract symptom in people with diabetes. We aimed to study the esophageal, gastric, and duodenal mucosal changes; presence of Helicobacter pylori (HP) infection; and its significance in dyspeptic diabetes patients. Materials and Methods: A prospective observational study done on 287 patients (147 patient with diabetes and 140 nondiabetic controls) with dyspepsia of more than 6 months duration. All patients underwent upper GI endoscopy and evaluation for HP infection. Gross and histopathological examination (HPE) features of biopsies from the esophagus, stomach (fundus, body, and antrum), and duodenum were analyzed and rapid urease test as well as HPE was done for HP detection. Statistical analysis was done and results were expressed as mean ± standard deviation. P < 0.05 was considered to be
statistically significant. Results: Average age for dyspeptic T2DM patients was 56.0 ± 8.44 years. Total 67.35% diabetes patients were addicted to tobacco. Epigastric pain and heartburn were the most common symptoms. Antral gastritis was the most common gross (75.08%) and HPE (70.38%) finding in patients with diabetes. In all, 44.21% patients with diabetes tested positive for HP infection, and there was a statistically significant association of HP with T2DM when compared with nondiabetics (P < 0.00001). However, HP infection did not correlate significantly with either glycosylated hemoglobin (HbA1c) or duration of T2DM. Conclusion: Antral gastritis was a common finding in dyspeptic diabetic patients. HP infection although associated with T2DM dyspeptic patients, was not associated with either uncontrolled sugar levels or duration of diabetes.
A Combination of Self‑Expansile Metallic Stent and External Beam Radiotherapy in Management of Advanced Esophageal Carcinoma with Grade III Dysphagia and Beyond
Authors: Joshi Mohan , Gadahire Minakshi , Paranjape Ashwini , Kamble Ranjeet , Pawar Vishwajeet , Ansari Khurshid , Jain Ankita , Patel Richa 
Published: November 2019

ABSTRACT
Background and Objectives: Most of the patients of Esophageal Malignancy present in advanced stage. These patients receive palliative treatment. We wanted to evaluate whether combination of SEMS and RT improves the grade of dysphagia. Methods: 165 patients diagnosed with Advanced Esophageal Malignancy in middle third of Esophagus with grade III dysphagia were enrolled for the study. Demographic data, grade of dysphagia, improvement in the grade of dysphagia, complications and survival were studied. Follow up was done for a period of 1 year. Results: All patients grade of dysphagia improved from grade III- IV to grade I-II. One patient had stent migration. Thirty patients died in one year Followup. Conclusion: SEMS along with RT may provide survival benefit in advanced Esophageal Malignancy.
Time to Play
Authors: Zimna Katarzyna 
Published: November 2019

‘Play art’ or interactive art is becoming a central concept in the contemporary art world, disrupting the traditional role of passive observance usually assumed by audiences, allowing them active participation. The work of ‘play’ artists - from Carsten Holler’s ‘Test Site’ at the Tate Modern to Gabriel Orozco’s ‘Ping Pond Table’ - must be touched, influenced and experienced; the gallery-goer is no longer a spectator but a co-creator. Time to Play explores the role of play as a central but neglected concept in aesthetics and a model for ground-breaking modern and postmodern experiments that have intended to blur the boundary between art and life. Moving freely between disciplines, Katarzyna Zimna links the theory and history of 20th and 21st century art with ideas developed within play, game and leisure studies, and the philosophical theories of Kant, Gadamer and Derrida, to critically engage with current discussion on the role of the artist, viewers, curators and their spaces of encounter.
She combines a consideration of the philosophical implications of play with the examination of how it is actually used in modern and postmodern art - looking at Dada, Surrealism, Fluxus and Relational Aesthetics. Focusing mainly on process-based art, this bold book proposes a fresh approach - reaching beyond classical cultural theories of play.
Left Shift
Authors: Walker John A. 
Published: November 2019

Compared to the 1960s, the 1970s is a neglected decade. This is a history of radical political art in Britain during the 1970s, art that sought to re-establish a social purpose. It argues that what was unique about the visual fine art of the decade was the impact of left-wing politics, women's liberation and the gay movement. Artists discussed include: Rashid Araeen, Conrad and Terry Atkinson, Joseph Beuys, Derek Boshier, Stuart Brisley, Victor Burgin, John Drugger, Gilbert and George, Margaret Harrison, Derek Jarman, John Latham, Mary Kelly, Bruce McLean, David Madalla, Jamie Reid, Jo Spence, John Stezaker and Stephen Willats who responded to the historical events of a period marked by economic and political crises. A wide variety of art forms is covered: banners, drawing, film, community murals, painting, performance, photography, photomontage, posters, sculpture and video. Many radical artists challenged prevailing art institutions, such as the Arts Council, often establishing alternatives, like the Artist's Union.
The book, which is set out on a year-by-year basis, also examines key conferences, exhibitions, galleries, magazines, organizations and critics; art theory and the various views of artists and critics meant that the 1970s was a decade of intellectual ferment.
Vzpomínky na vývoj katedry mezinárodního (a evropského) práva v Brně a rozvoj oborů mezinárodní právo veřejné a právo EU v letech 1974–2019
Authors: Týč Vladimír 
Published: November 2019

Cíl této studie je dvojí. Je především stručným pohledem na historii katedry mezinárodního (a evropského) práva od jejího založení do současnosti, zejména pokud jde o personální složení a odborné zaměření. Druhým cílem je zmapování a vyhodnocení přínosu katedry k rozvoji oborů mezinárodní právo veřejné a právo EU, včetně větve duševního vlastnictví. O oboru mezinárodní právo soukromé pojednává zvláštní studie.Pro přehlednost je text členěn do tří částí, odpovídajících třem obdobím: první do roku 1990, druhé poté do roku 2010 a třetí zahrnující poslední léta a současnost. Zatímco první období bylo ve znamení rozjezdu a budování nové katedry na nové fakultě, druhé období znamenalo v nových podmínkách bouřlivý rozvoj odborné i pedagogické činnosti. Katedra rozšířila svoji působnost o nový velmi dynamický obor právo Evropské unie. V posledním období do současnosti pokračuje bohatá vědecká a pedagogická činnost a stabilizuje se personální složení týmu katedry.Studie dochází k závěru, že katedra významnou měrou přispívá k rozvoji svých oborů, zajišťuje bohatou a hodnotnou pedagogickou činnost a dostala se tak na špičku podobných pracovišť v ČR.
Mít zájem o svůj obor a dobrý vztah ke studujícím
Authors: Hajn Petr 
Published: November 2019

Autor statě zasvěcenou i zábavnou formou vypráví o svém studiu na pražské právnické fakultě a zjišťuje, co mu toto studium přineslo pro jeho pozdější činnost v podnikové praxi a dlouholeté působení jako pedagoga na právnické fakultě v Brně. Přináší tak i obecnější podnětná zjištění o počínání a mentalitě vysokoškolských učitelů a jejich studentů.
High-exposure-durability, high-quantum-efficiency (>90%) backside-illuminated soft-X-ray CMOS sensor
Authors: Harada Tetsuo , Teranishi Nobukazu , Watanabe Takeo , Zhou Quan , Bogaerts Jan , Wang Xinyang 
Published: November 2019

Abstract
We develop a high-quantum-efficiency, high-exposure-durability backside-illuminated CMOS image sensor for soft-X-ray detection. The backside fabrication process is optimized to reduce the dead-layer thickness, and the Si-layer thickness is increased to 9.5 μm to reduce radiation damage. Our sensor demonstrates a high quantum efficiency of >90% in the photon-energy range of 80–1000 eV. Further, its EUV-regime efficiency is ∼100% because the dead-layer thickness is only 5 nm. The readout noise is as low as 2.5 e− rms and the frame rate as high as 48 fps, which makes the device practical for general soft X-ray experiments.
Computer-aided simulation and exergy analysis of TiO2 nanoparticles production via green chemistry
Authors: Meramo-Hurtado Samir , Moreno-Sader Kariana , González-Delgado Ángel D. 
Published: November 2019

Background
The production of photocatalytic nanoparticles such as TiO2 has received increasing interest for biomedical and wastewater treatment applications. However, the conventional synthesis of such materials faces several environmental concerns.

Methods
In this work, green synthesis is addressed to prepare TiO2 nanoparticles at large scale using Lemongrass (Cymbopogon citratus) and titanium isopropoxide (TTIP). This process was designed and modeled using computer-aided process engineering (CAPE) in order to obtain the extended mass/energy balances, as well as operating parameters. Process simulation was carried out using the commercial software Aspen Plus®. In addition, energy performance of large-scale nanoparticle production was analyzed to identify alternatives for process improvement from an exergetic point of view.

Results
The production capacity of the plant was estimated as 1,496 t/y of TiO2 nanoparticles by the conversion of 32,675 t/y lemongrass and 5,724 t/y TTIP. Hence, the overall production yield is 0.26 kg TiO2/kg TTIP. Exergy analysis reported an overall exergy efficiency of 0.27% and an exergy loss of 159,824.80 MJ/h. These results suggest that such a process requires the implementation of process improvement strategies to reach a more sustainable design from energy and thermodynamic viewpoints.
RNA‐sequence‐based microRNA expression signature in breast cancer: tumor‐suppressive miR‐101‐5p regulates molecular pathogenesis
Authors: Toda Hiroko , Seki Naohiko , Kurozumi Sasagu , Shinden Yoshiaki , Yamada Yasutaka , Nohata Nijiro , Moriya Shogo , Idichi Tetsuya , Maemura Kosei , Fujii Takaaki , Horiguchi Jun , Kijima Yuko , Natsugoe Shoji 
Published: November 2019

Aberrantly expressed microRNA (miRNA) are known to disrupt intracellular RNA networks in cancer cells. Exploring miRNA‐dependent molecular networks is a major challenge in cancer research. In this study, we performed RNA‐sequencing of breast cancer (BrCa) clinical specimens to identify tumor‐suppressive miRNA in BrCa. In total, 64 miRNA were identified as candidate tumor‐suppressive miRNA in BrCa cells. Analysis of our BrCa signature revealed that several miRNA duplexes (guide strand/passenger strand) derived from pre‐miRNA were downregulated in BrCa tissues (e.g. miR‐99a‐5p/‐3p, miR‐101‐5p/‐3p, miR‐126‐5p/‐3p, miR‐143‐5p/‐3p, and miR‐144‐5p/‐3p). Among these miRNA, we focused on miR‐101‐5p, the passenger strand of pre‐miR‐101, and investigated its tumor‐suppressive roles and oncogenic targets in BrCa cells. Low expression of miR‐101‐5p predicted poor prognosis in patients with BrCa (overall survival rate: P = 0.0316). Ectopic expression of miR‐101‐5p attenuated aggressive phenotypes, e.g. proliferation, migration, and invasion, in BrCa cells. Finally, we identified seven putative oncogenic genes (i.e. High Mobility Group Box 3, Epithelial splicing regulatory protein 1, GINS complex subunit 1 (GINS1), Tumor Protein D52, Serine/Arginine‐Rich Splicing Factor Kinase 1, Vang‐like protein 1, and Mago Homolog B) regulated by miR‐101‐5p in BrCa cells. The expression of these target genes was associated with the molecular pathogenesis of BrCa. Furthermore, we explored the oncogenic roles of GINS1, whose function had not been previously elucidated, in BrCa cells. Aberrant expression of GINS1 mRNA and protein was observed in BrCa clinical specimens, and high GINS1 expression significantly predicted poor prognosis in patients with BrCa (overall survival rate: P = 0.0126). Knockdown of GINS1 inhibited the malignant features of BrCa cells. Thus, identification of tumor‐suppressive miRNA and molecular networks controlled by these miRNA in BrCa cells may be an effective strategy for elucidation of the molecular pathogenesis of this disease.
A study on the visibility of chromatic and achromatic color lines to visually challenged people
Authors: Iwata Michico , Kitamoto Hiroyuki 
Published: November 2019

AbstractVisually challenged people require visual contrasts between targets and backgrounds. The authors performed a laboratory experiment to gauge the visibility of lines under 100 and 1000 lx illuminance conditions. These lines provide an essential reference point for the visually challenged when walking. In this paper, we test their visibility, based on the contrast of lines and backgrounds, in chromatic and achromatic color combinations. A total of 43 colors were used for the target lines, and three achromatic colors were used for the backgrounds. Therefore, a total of 129 color combinations were used. Data from this experiment may assist in the design of walking lines on pavement surfaces, which can provide directions, warnings and other useful guidance to visually challenged people.
A Naturally Integrated Smart Textile for Wearable Electronics Applications
Authors: Zhao Jingjing , Fu Yulin , Xiao Yuxiang , Dong Ying , Wang Xiaohao , Lin Liwei 
Published: November 2019

AbstractSmart textiles, which integrate different electronic devices in yarns, fabrics, or garments, have the ability to perceive and respond to environmental stimuli. With the features of mechanical flexibility, knittable integration, and wearable comfort, smart textiles have great potential in wearable electronics. Here, a naturally integrated force sensing textile based on knittable composite coaxial fibers is proposed. A flexible commercial nylon fiber works as a substrate, an evaporated Au layer serves as an inner electrode, and carbon nanotubes and polyaniline act as piezoresistive sensing materials in the coaxial fibers. The assembled sensor retains both high detection performance and outstanding integration properties. A high detection limit, fast response, reversible recovery, mechanical stability, and good repeatability are realized in this sensor. Subsequently, the potential of using a coaxial fiber to achieve naturally knitted structures by an embroidery method is explored. A sensing array can be integrated into designed patterns and can achieve multiple site force measurements. Furthermore, with the flexibility and porosity of textiles, these smart textiles provide breathability in wearable applications, which is valuable in long‐term detection. It is anticipated that the naturally knitted smart textile will be practical in wearable healthcare and long‐term force perception.
Highly Efficient, Simplified Monochrome and White Organic Light‐Emitting Devices based on Novel Exciplex Host
Authors: Sheng Ren , Li Asu , Zhang Fujun , Song Jian , Duan Yu , Chen Ping 
Published: November 2019

AbstractThe exciplex co‐host system is one of the most promising candidates for developing phosphorescent organic light‐emitting diodes (OLEDs) with high performance. However, highly effective exciplex co‐host system that is able to realize color‐pure monochrome OLED and superior color‐stable white OLED simultaneously is rarely reported so far. Herein, a novel exciplex co‐host system formed by the donor of (N,N′‐dicarbazolyl‐3,5‐benzene) (MCP) and the acceptor of 4,6‐bis[3,5‐(dipyrid‐3‐yl)‐phenyl]‐2‐phenylpyrimidine (B4PyPPM) is constructed successfully to achieve efficient phosphorescent OLEDs. By employing simple device structure with only two organic transport materials, the blue, green, orange, and red phosphorescent OLEDs based on the universal exciplex co‐host exhibit stable color purity as well as maximum external quantum efficiencies of 20.1%, 26.3%, 24.6%, 19.8%, respectively. By combining blue and orange emitters, white OLED with a high efficiency of 73.6 lm W−1 is demonstrated with an extremely minor Commission Internationale de L, Eclairage coordinates variation of (0.008, 0.002) over a large luminance range, which is attributed to the balanced charge transport property and multiple funneling energy transfer paths.
Biallelic variants p.Arg1133Cys and p.Arg1379Cys in COL2A1: Further delineation of phenotypic spectrum of recessive Type 2 collagenopathies
Authors: Girisha Katta M. , Bhavani Gandham S. , Shah Hitesh , Moirangthem Amita , Shukla Anju , Kim Ok‐Hwa , Nishimura Gen , Mortier Geert R. 
Published: November 2019

AbstractThe phenotypic spectrum of Type 2 collagenopathies ranges from lethal achondrogenesis Type 2 to milder osteoarthritis with mild chondrodysplasia. All of them are monoallelic except for the two recent reports showing that biallelic variants in COL2A1 can cause spondyloepiphyseal dysplasia congenita in two children. Here we report two additional families with homozygous variants, c.4135C>T (p.Arg1379Cys) and c.3190C>T (p.Arg1133Cys) in COL2A1 resulting in two distinct skeletal dysplasia phenotypes of intermediate severity. Though all six patients from four families exhibit a spondylo‐epimetaphyseal dysplasia, they demonstrate a wide variation in severity of short stature and involvement of epiphyses, metaphyses, and vertebrae. We hypothesize that the variants are likely to be hypomorphic, given the underlying mechanisms of disease causation for known heterozygous variants in COL2A1. With this report, we provide further evidence to the existence of autosomal recessive Type 2 collagenopathy.
SCN1A Variants in vaccine‐related febrile seizures: A prospective study
Authors: Damiano John A. , Deng Lucy , Li Wenhui , Burgess Rosemary , Schneider Amy L. , Crawford Nigel W. , Buttery Jim , Gold Michael , Richmond Peter , Macartney Kristine K. , Hildebrand Michael S. , Scheffer Ingrid E. , Wood Nicholas , Berkovic Samuel F. 
Published: November 2019

ObjectiveFebrile seizures may follow vaccination. Common variants in the sodium channel gene, SCN1A, are associated with febrile seizures, and rare pathogenic variants in SCN1A cause the severe developmental and epileptic encephalopathy Dravet syndrome. Following vaccination, febrile seizures may raise the specter of poor outcome and inappropriately implicate vaccination as the cause. We aimed to determine the prevalence of SCN1A variants in children having their first febrile seizure either proximal to vaccination or unrelated to vaccination compared to controls.MethodsWe performed SCN1A sequencing, blind to clinical category, in a prospective cohort of children presenting with their first febrile seizure as vaccine proximate (n = 69) or as non–vaccine proximate (n = 75), and children with no history of seizures (n = 90) recruited in Australian pediatric hospitals.ResultsWe detected 2 pathogenic variants in vaccine‐proximate cases (p.R568X and p.W932R), both of whom developed Dravet syndrome, and 1 in a non–vaccine‐proximate case (p.V947L) who had febrile seizures plus from 9 months. All had generalized tonic–clonic seizures lasting >15 minutes. We also found enrichment of a reported risk allele, rs6432860‐T, in children with febrile seizures compared to controls (odds ratio = 1.91, 95% confidence interval = 1.31–2.81).InterpretationPathogenic SCN1A variants may be identified in infants with vaccine‐proximate febrile seizures. As early diagnosis of Dravet syndrome is essential for optimal management and outcome, SCN1A sequencing in infants with prolonged febrile seizures, proximate to vaccination, should become routine. ANN NEUROL 2020;87:281–288
Palladium‐Catalyzed Asymmetric [4+3] Cyclization of Trimethylenemethane: Regio‐, Diastereo‐, and Enantioselective Construction of Benzofuro[3,2‐b]azepine Skeletons
Authors: Liu Yang‐Zi , Wang Zhongao , Huang Zesheng , Zheng Xing , Yang Wu‐Lin , Deng Wei‐Ping 
Published: November 2019

AbstractThe palladium‐catalyzed asymmetric [4+3] cyclization of trimethylenemethane donors with benzofuran‐derived azadienes furnishes chiral benzofuro[3,2‐b]azepine frameworks in high yields (up to 98 %) with exclusive regioselectivities and excellent stereoselectivities (up to >20:1 d.r., >99 % ee). This catalytic asymmetric [4+3] cyclization of Pd‐trimethylenemethane can enrich the arsenal of Pd‐TMM reactions in organic synthesis. In addition, this strategy provides an alternative approach to chiral azepines by a transition‐metal‐catalyzed asymmetric [4+3] cyclization.
Regiodivergent Intramolecular Nucleophilic Addition of Ketimines for the Diverse Synthesis of Azacycles
Authors: Wang Yu‐Hui , Tian Jun‐Song , Tan Peng‐Wei , Cao Qiang , Zhang Xue‐Xin , Cao Zhong‐Yan , Zhou Feng , Wang Xin , Zhou Jian 
Published: November 2019

AbstractAzacycles such as indoles and tetrahydroquinolines are privileged structures in drug development. Reported here is an unprecedented regiodivergent intramolecular nucleophilic addition reaction of imines as a flexible approach to access N‐functionalized indoles and tetrahydroquinolines, by the control of reaction at the N‐terminus and C‐terminus, respectively. Using ketimines derived from 2‐(2‐nitroethyl)anilines with isatins or α‐ketoesters, the regioselective N‐attack reaction gives N‐functionalized indoles, while the catalytic enantioselective C‐attack reaction affords chiral tetrahydroquinolines featuring an α‐tetrasubstituted stereocenter. Mechanistic studies reveal that hydrogen‐bonding interactions may greatly facilitate such unusual N‐attack reactions of imines. The utility of this protocol is highlighted by the catalytic enantioselective formal synthesis of (−)‐psychotrimine, and the construction of various fused aza‐heterocycles.