bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hoe het toezicht rekening kan houden met de context van een zorgaanbieder
Authors: Ketelaars Corry , Spronk Sandra , Leistikow Ian 
Published: November 2020

Hoe het toezicht rekening kan houden met de context van een zorgaanbieder – Context matters
De context van een zorgaanbieder speelt een rol bij de afweging of de IGJ vertrouwen heeft in een zorgaanbieder. Afhankelijk van het vertrouwen kiest de inspectie voor een meer op leren gerichte, dan wel een meer disciplinerende interventie. In de praktijk is de uitdaging voor inspecteurs te expliciteren wat die context is en hoe die te wegen in het bepalen van de interventie om daarmee toezicht op maat te kunnen leveren. Dit onderzoek beantwoordt de vraag: ‘Wat zijn de belangrijkste contextfactoren die de kwaliteit van de zorg van een zorgaanbieder kunnen beïnvloeden?’. Het onderzoek had een kwalitatieve opzet en was een combinatie van conceptanalyse, literatuuronderzoek, interviews met experts, focusgroepdiscussies en toetsing van contextfactoren door inspecteurs en onderzoek van inspectierapporten. Het resultaat hiervan is het kader ‘Context van een zorgaanbieder’ met vier categorieën: Toezichtgeschiedenis, Organisatorische context, Bestuurlijke context en Maatschappelijke context.Het kader ‘Context van een zorgaanbieder’ is geïntegreerd in het Afwegingskader Vertrouwen van de IGJ. Dit geeft de inspecteur handvatten om af te wegen of en hoe de context invloed heeft op het vertrouwen in de zorgaanbieder en een toezichtinterventie in te zetten die het beste bijdraagt aan het doel, namelijk het verbeteren van de kwaliteit van zorg.
Is datagedreven risicogebaseerd toezicht op termijn effectief?
Authors: van der Voort Haiko , Sedee Ivo , Booijink Tom , van der Vaart Elske 
Published: November 2020

Is datagedreven risicogebaseerd toezicht op termijn effectief?
Welke effecten kunnen we op termijn verwachten als inspecteurs op basis van data risicogebaseerd gaan werken? We hebben een agentgebaseerd model ontwikkeld waarmee we verschillende scenario’s kunnen testen. Het model bevestigt het potentieel van datagedreven toezicht op de effectiviteit voor inspecties. Maar het waarschuwt ook voor bias, omdat met datagedreven toezicht alleen data van risicovolle bedrijven worden verkregen. Een beperkt aantal willekeurige inspecties kan de datakwaliteit al fors doen toenemen. Daarmee waarschuwen we voor te veel optimisme over de efficiëntie van datagedreven risicogebaseerd toezicht. Bovendien reiken we een model aan waarmee een optimum tussen datagedreven en willekeurige inspecties te bepalen is.
Direct Growth of Germanene at Interfaces between Van der Waals Materials and Ag(111)
Authors: Suzuki Seiya , Iwasaki Takuya , De Silva K. Kanishka H. , Suehara Shigeru , Watanabe Kenji , Taniguchi Takashi , Moriyama Satoshi , Yoshimura Masamichi , Aizawa Takashi , Nakayama Tomonobu 
Published: November 2020

AbstractGermanene, a 2D honeycomb germanium crystal, is grown at graphene/Ag(111) and hexagonal boron nitride (h‐BN)/Ag(111) interfaces by segregating germanium atoms. A simple annealing process in N2 or H2/Ar at ambient pressure leads to the formation of germanene, indicating that an ultrahigh‐vacuum condition is not necessary. The grown germanene is stable in air and uniform over the entire area covered with a van der Waals (vdW) material. As an important finding, it is necessary to use a vdW material as a cap layer for the present germanene growth method since the use of an Al2O3 cap layer results in no germanene formation. The present study also proves that Raman spectroscopy in air is a powerful tool for characterizing germanene at the interfaces, which is concluded by multiple analyses including first‐principles density functional theory calculations. The direct growth of h‐BN‐capped germanene on Ag(111), which is demonstrated in the present study, is considered to be a promising technique for the fabrication of future germanene‐based electronic devices.
Weakly Humidity‐Dependent Proton‐Conducting COF Membranes
Authors: Cao Li , Wu Hong , Cao Yu , Fan Chunyang , Zhao Rui , He Xueyi , Yang Pengfei , Shi Benbing , You Xinda , Jiang Zhongyi 
Published: November 2020

AbstractState‐of‐the‐art proton exchange membranes (PEMs) often suffer from significantly reduced conductivity under low relative humidity, hampering their efficient application in fuel cells. Covalent organic frameworks (COFs) with pre‐designable and well‐defined structures hold promise to cope with the above challenge. However, fabricating defect‐free, robust COF membranes proves an extremely difficult task due to the poor processability of COF materials. Herein, a bottom‐up approach is developed to synthesize intrinsic proton‐conducting COF (IPC‐COF) nanosheets (NUS‐9) in aqueous solutions via diffusion and solvent co‐mediated modulation, enabling a controlled nucleation and in‐plane‐dominated IPC‐COF growth. These nanosheets allow the facile fabrication of IPC‐COF membranes. IPC‐COF membranes with crystalline, rigid ion nanochannels exhibit a weakly humidity‐dependent conductivity over a wide range of humidity (30–98%), 1–2 orders of magnitude higher than that of benchmark PEMs, and a prominent fuel cell performance of 0.93 W cm−2 at 35% RH and 80 °C arising from superior water retention and Grotthuss mechanism‐dominated proton conduction.
Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA‐Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines
Authors: Kumar Sukumar Uday , Telichko Arsenii V. , Wang Huaijun , Hyun Dongwoon , Johnson Eric G. , Kent Michael S. , Rebhun Robert B. , Dahl Jeremy J. , Culp William T. N. , Paulmurugan Ramasamy 
Published: November 2020

AbstractSpatially localized microbubble cavitation by ultrasound offers an effective means of altering the permeability of natural barriers (i.e., blood vessels and cell membranes) in favor of nanomaterial accumulation in target sites. In this study, a clinically relevant, minimally invasive ultrasound guided therapeutic approach is investigated for the targeted delivery of anticancer microRNA loaded PLGA‐b‐PEG nanoparticles to spontaneous hepatocellular neoplasia in a canine model. Quantitative assessment of the delivered microRNAs reveals a prominent and consistent increase in microRNAs levels (1.5‐ to 2.3‐fold increase [p < 0.001]) in ultrasound treated tumor regions compared to untreated control regions. The immunohistology of ultrasound treated tumor tissue presents clear evidence for a higher amount of nanoparticle extravasation from the blood vessels. A distinct pattern of cytokine expression supporting a CD8+ T cells mediated “cold‐to‐hot” tumor transition is evident in all patients. This proposed platform can enhance delivery of microRNA‐loaded nanoparticles to deeply located visceral tumors in large animals to enhance chemotherapy.
Conceptual design of chemical devices
Authors: Ho Elliot Ngou‐Tin , Fung Ka Yip , Wibowo Christianto , Zhang Xiang , Ng Ka Ming 
Published: November 2020

AbstractChemical devices are chemical products that transform a feed stream into an outlet stream with the desired attributes by performing reaction, fluid flow, heating, cooling, and/or separations. They resemble small chemical plants and can be described by device flowsheets, similar to the process flowsheets of chemical plants. This article proposes a generic design framework for chemical devices. It shares some steps with Douglas' hierarchical design procedure for chemical processes but has its own distinguishing features such as capturing of consumer preferences, formulation of an engineering statement, and the use of unconventional processing techniques in device manufacturing. Two examples, domestic dehumidifier and air purifier, are discussed to illustrate the design framework. A new dehumidifier design was found using this framework.
Indications for early plasma transfusion and its optimal use following trauma
Authors: Otsuka Hiroyuki , Sakoda Naoki , Uehata Atsushi , Sato Toshiki , Sakurai Keiji , Aoki Hiromichi , Yamagiwa Takeshi , Iizuka Shinichi , Inokuchi Sadaki 
Published: November 2020

AimThis study aimed to evaluate the effect of plasma transfusion before urgent hemostasis initiation on in‐hospital mortality in hemodynamically unstable patients with severe trauma.MethodsThis retrospective observational study of patients admitted to hospital between January 2011 and January 2019 grouped patients according to whether plasma transfusion was initiated before (Before group) or after (After group) hemostasis initiation. Patients with severe trauma who were unable to wait for plasma transfusion and had started hemostasis before the plasma infusion were excluded. We used multivariable logistic regression analysis to determine the effect of plasma transfusion before the initiation of urgent hemostasis on in‐hospital mortality.ResultsWe included 47 and 73 patients in the Before and After groups, respectively. Blunt trauma was more common, and the D‐dimer levels and Injury Severity Score were significantly higher in the Before group than in the After group (median D‐dimer, 57.5 versus 38.1 μg/mL; P = 0.040; median Injury Severity Score, 50 versus 34; P < 0.001). Plasma given before hemostasis initiation was associated with significantly lower in‐hospital mortality (adjusted odds ratio, 0.27; 95% confidence interval, 0.078–0.900; P = 0.033) in contrast with the total plasma volume given in the first 6 or 24 h.ConclusionPlasma transfusion before hemostasis initiation could be an important factor for improving outcomes in hemodynamically unstable patients with blunt trauma, high D‐dimer levels, or a high Injury Severity Score.
Tricuspid valve Swan‐Ganz catheter entrapment before cardiac surgery
Authors: Colombier S. , Rancati V. , Marcucci C. , Lavanchy J. , Kirsch M. , Niclauss L. 
Published: November 2020

SummaryA Swan‐Ganz catheter during cardiac surgery offers peri‐operative haemodynamic monitoring, although insertion of these catheters is not without risk. We report a case of Swan‐Ganz catheter entrapment within the tricuspid valve during elective off‐pump coronary artery bypass surgery. The diagnosis was made immediately by transoesophageal echocardiography, thus preventing forced withdrawal of the catheter. Intra‐operatively, the echocardiographically detected findings of complex entrapment was confirmed. The Swan‐Ganz catheter was tightly wrapped around the subvalvular apparatus, requiring on‐pump open surgical removal. This case illustrates the anatomical complexity of such a catheter entrapment around the tricuspid valve apparatus and the importance of rapid echocardiographic diagnosis to prevent iatrogenic damage.
Poly(vinylidene‐co‐hexafluoropropylene) membrane modified with glass fibers and polyvinyl pyrrolidone: Mechanical and electrochemical properties
Authors: Zheng Pengxuan , Qiu Jiye , Wang Xiangwei , Yu Zhiwei , Ma Yong , Li Tingxi 
Published: November 2020

AbstractThe polymer electrolytes based on poly(vinylidene‐co‐hexafluoropropylene) (PVDF‐co‐HFP) have been widely studied and applied in devices for its excellent electrochemical and mechanical properties. Here, porous PVDF‐co‐HFP membrane modified with glass fibers (GFs) and polyvinyl pyrrolidone (PVP) were fabricated by phase‐transfer method. When the dosage of GFs exceeded 1 wt%, the composite membranes exhibited 6.11 MPa tensile strength. When the dosage of GFs and PVP reached 1% (PVP1GF1), respectively, the composite membranes in porous network structure possessed the highest electrolyte uptake of 251.02%, the thermal stability of 343°C and the ionic conductivity of 3.05 × 10−3 S cm−1. Electrochromic device (ECD) was assembled with PVP1GF1 electrolyte, showing quick responses between the bleached and the color states within 3 s. The PVDF‐co‐HFP composite electrolyte was expected to be effective substitutes for liquid electrolytes used in ECDs.
A review on the self‐healing ability of epoxy polymers
Authors: Zhang Fenglei , Zhang Lei , Yaseen Muhammad , Huang Kai 
Published: November 2020

AbstractThis review encompasses the research progress on self‐healing properties of epoxy polymers and is divided into two categories: material supplement and energy supplement. The central concept of material supplement revolves around the addition of functional composite materials, such as, hollow fiber and microcapsule, to repair the micro‐cracks of epoxy polymers. In contrast, the energy supplement is based on the concurrent incorporation of some functional groups into the thermosetting epoxy polymers. These functional chemical groups participate in the construction of a three‐dimensional network structure of thermosetting materials and successfully enter the block copolymer of epoxy polymers. When the micro‐cracks are developed in the resin upon exterior impact, these functional groups automatically absorb energy from the outside to perform chemical reactions and automatically repair their micro‐cracks following the self‐healing phenomenon. Five kinds of reversible reactions are introduced for energy supply and are discussed in detail. Finally, a summary and comparison of the self‐healing methods covered in this review and the application prospect of self‐healing epoxy polymers are summarized.
Ribosomal protein uS3 in cell biology and human disease: Latest insights and prospects
Authors: Graifer Dmitri , Karpova Galina 
Published: November 2020

AbstractThe conserved ribosomal protein uS3 in eukaryotes has long been known as one of the essential components of the small (40S) ribosomal subunit, which is involved in the structure of the 40S mRNA entry pore, ensuring the functioning of the 40S subunit during translation initiation. Besides, uS3, being outside the ribosome, is engaged in various cellular processes related to DNA repair, NF‐kB signaling pathway and regulation of apoptosis. This review is devoted to recent data opening new horizons in understanding the roles of uS3 in such processes as the assembly and maturation of 40S subunits, ensuring proper structure of 48S pre‐initiation complexes, regulation of initiation and ribosome‐based RNA quality control pathways. Besides, we summarize novel results on the participation of the protein in processes beyond translation and consider biomedical implications of previously known and recently found extra‐ribosomal functions of uS3, primarily, in oncogenesis.
Determination of the concentration of gilteritinib in human plasma using HPLC
Authors: Yasu Takeo , Sugi Tomiyuki , Momo Kenji , Hagihara Masao , Yasui Hiroshi 
Published: November 2020

AbstractGilteritinib, an oral inhibitor of FMS‐like tyrosine kinase 3 (FLT3), is a standard treatment for FLT3‐mutated acute myeloid leukemia. We developed a simple HPLC‐UV‐based method for determining the concentration of gilteritinib in human plasma. The analysis requires the extraction of a 200‐μL plasma sample and the precipitation of proteins by solid‐phase extraction. Gilteritinib was isocratically separated within 10 min using a mobile phase of acetonitrile:0.5% monopotassium phosphate (KH2PO4, pH 3.5, 28:72, v/v) on a Capcell Pack C18 MG II (250 × 4.6 mm) column at a flow rate of 1.0 mL/min and monitored at 250 nm. The calibration curve was found to be linear within a plasma concentration range of 25–2500 ng/mL, with the coefficient of determination (r2) being 0.9997. The coefficients of intra‐day and inter‐day validation were 2.3–3.7 and 1.3–5.2%, respectively. The accuracy and recovery of the assay were −9.6 to 0.1 and >81.8%, respectively. This HPLC‐UV method for determining the plasma concentration of gilteritinib is simple and can be effectively applied to routine drug monitoring.
Resting‐state default mode network connectivity in young individuals with Down syndrome
Authors: Figueroa‐Jimenez María Dolores , Cañete‐Massé Cristina , Carbó‐Carreté María , Zarabozo‐Hurtado Daniel , Peró‐Cebollero Maribel , Salazar‐Estrada José Guadalupe , Guàrdia‐Olmos Joan 
Published: November 2020

AbstractBackgroundDown syndrome (DS) is a chromosomal disorder that causes intellectual disability. Few studies have been conducted on functional connectivity using resting‐state fMRI (functional magnetic resonance imaging) signals or more specifically, on the relevant structure and density of the default mode network (DMN). Although data on this issue have been reported in adult DS individuals (age: >45 years), the DMN properties in young DS individuals have not been studied. The aim of this study was to describe the density and structure of the DMN network from fMRI signals in young DS (age: <36 years).MethodA sample of 22 young people with DS between the ages of 16 and 35 (M = 25.5 and SD = 5.1) was recruited in various centers for people with intellectual disability (ID). In addition to sociodemographic data, a six‐minute fMRI session was recorded with a 3. T Philips Ingenia scanner. A control group of 22 young people, matched by age and gender, was obtained from the Human Connectome Project (to compare the networks properties between groups).ResultsThe values of the 48 ROIs that configured the DMN were obtained, and the connectivity graphs for each subject, the average connectivity graph for each group, the clustering and degree values for each ROI, and the average functional connectivity network were estimated.ConclusionsA higher density of overactivation was identified in DS group in the ventral, sensorimotor, and visual DMN networks, although within a framework of a wide variability of connectivity patterns in comparison with the control group network. These results extend our understanding of the functional connectivity networks pattern and intrasubject variability in DS.
Atypical parkinsonian syndromes in a North African tertiary referral center
Authors: Nasri Amina , Ben Djebara Mouna , Sghaier Ikram , Mrabet Saloua , Zidi Sabrina , Gargouri Amina , Kacem Imen , Gouider Riadh 
Published: November 2020

AbstractIntroductionData on epidemiology of atypical parkinsonian syndromes (APS) in North African countries are limited. Our objective was to study the epidemiological features of APS in a Tunisian population.MethodsWe conducted a 17‐year retrospective cross‐sectional descriptive study in the Department of Neurology at Razi University Hospital. We included all patients responding to consensus diagnosis criteria of APS. We recorded demographic and clinical data. Group differences were assessed with a post hoc ANOVA with a Bonferroni error correction.ResultsWe included 464 APS patients. Hospital prevalence of APS among all parkinsonism cases was 20.6%. Mean annual increase of incidence defined as newly diagnosed APS cases per year reached 38.8%/year. APS were divided into 4 etiological subgroups: dementia with Lewy bodies (DLB; 56.7%); progressive supranuclear palsy(PSP; 16.2%); multiple system atrophy (MSA; 14.6%); and finally corticobasal syndrome (CBS; 12.5%). Sex‐ratio was 1.2. This male predominance was found in all subgroups except MSA (p = .013). Mean age at onset was 68.5 years, most belated in DLB (69.7 years; p < .001). Young‐onset parkinsonism (<40 years) was found only in MSA subgroup (p = .031). Parkinsonism was of late onset (>70 years) in 50.7% of patients and was significantly associated with DLB subgroup (p = .013). Inaugural parkinsonism was associated with CBS and MSA (p = .0497), and gait disorders at disease onset were associated with PSP and MSA (p = .0062). Cognitive and mood disorders were more marked in DLB and most preserved in MSA. Consanguinity was more marked in CBS (p = .037), and family history of dementia and psychiatric diseases was more common in DLB. Thirty‐seven families with similar cases of APS were identified.ConclusionsThis is the largest African epidemiological study on APS. In our population, APS were frequent and dominated by DLB. The age of onset of parkinsonism was the most decisive feature for differential diagnosis.
On the use of computer‐assistance to facilitate systematic mapping
Authors: Haddaway Neal R. , Callaghan Max W. , Collins Alexandra M. , Lamb William F. , Minx Jan C. , Thomas James , John Denny 
Published: November 2020

AbstractThe volume of published academic research is growing rapidly and this new era of “big literature” poses new challenges to evidence synthesis, pushing traditional, manual methods of evidence synthesis to their limits. New technology developments, including machine learning, are likely to provide solutions to the problem of information overload and allow scaling of systematic maps to large and even vast literatures. In this paper, we outline how systematic maps lend themselves well to automation and computer‐assistance. We believe that it is a major priority to consolidate efforts to develop and validate efficient, rigorous and robust applications of these novel technologies, ensuring the challenges of big literature do not prevent the future production of systematic maps.
Predicting the actual location of faults in underground optical networks using linear regression
Authors: Nyarko‐Boateng Owusu , Adekoya Adebayo Felix , Weyori Benjamin Asubam 
Published: November 2020

AbstractOptical cables are enormous transmission media that carry high‐speed data across transatlantic, intercontinental, international boundaries, and cities. The optical cable is essential in data communication. The cable has become an indispensable component in optical communications infrastructure; hence, conscious efforts are always adopted to prevent or minimize faults in the optical network infrastructure. Typically, tracing fault in the underground optical network has been difficult even though the optical time‐domain reflectometer (OTDR) has been used to measure the distance of faults in the underground fiber cable. The methodologies deployed in the reviewed literature indicate a vast gap between the fault distance measured by the OTDR and the actual distance of fault. This paper observed the difficulties involved in tracing the actual spot of fault in the underground optical networks. The difficulty of tracing these underground faults mostly result in an undue delay and loss of revenue. This research presents a machine learning approach to predict the actual location of a fiber cable fault in an underground optical transmission link. Linear regression in the python sci‐kit learn library was used to predict the actual location of a fault in an underground optical network. The mean square error and MAE evaluation matrix used provided good accuracy results of 0.061291 and 0.080143, respectively. The result obtained in this paper indicates that faults in underground optical networks can be found quickly to avoid the delays in the fault tracing process, which leads to an excessive revenue loss.