bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIY et hacking dans la musique noise. Une expérimentation bricoleuse du dispositif de jeu
Authors: Benhaïm Sarah 
Published: November 2019

Depuis sa genèse à la fin des années 1970, la musique noise se distingue par des pratiques instrumentales étroitement liées à une culture d’expérimentation alternative. Parmi elles, le hacking et le DIY teintent en profondeur les manières de composer le dispositif de jeu en plus de gouverner les rapports d’apprentissage et de transmission qui structurent éthiquement et économiquement le genre. Pour rendre compte de la manière dont intervient le hacking dans la noise, l’article explore successivement les pratiques amateures qui s’apparentent au bricolage, au détournement et à la conception électronique d’instruments. Si ces manières de faire sont empreintes d’autodidaxie et participent à reconfigurer la figure du musicien en déplaçant la compétence instrumentale conventionnelle vers le bricolage et l’ingénierie, elles se transmettent aussi par le biais de ressources mutualisées au sein d’ateliers ou par l’intermédiaire d’une communauté internet associée à l’open source. Dans ces lieux de partages et au cœur des gestes bricoleurs se loge, en correspondance étroite à l’éthique hacker et au précepte DIY qui structure l’éthos de la noise, une approche anti-consumériste de l’instrumentation qui défend également l’autonomie des pratiques, l’accessibilité du savoir et la sérendipité bruitiste.
Effect of Urinary Retention on the Satisfaction and Complication Rate in Benign Prostatic Hyperplasia Patients Undergoing Prostatectomy
Authors: Banakhar Mai A. 
Published: November 2019

A cohort study from January 2000 till January 2005 included all patients who underwent prostatic surgery with histopathology report of benign prostatic hyperplasia. Patients were divided into elective or retention group. Data of patient demographics, satisfaction and postoperative complications were collected. Total of 119 patients, retention (n = 30), elective group (n = 89). Retention rate was 25%. There was no eff ect of retention on postoperative complication (elective = 44%, retention = 41%) p value = 0.826, odds ratio 0.878, CI (0.363 - 2.124) nor any eff ect on patients' satisfaction (elective = 54%, retention = 59%) p value = 0.661, odds ration = 1.256, CI (0.520 - 3.034). Patients’ age and prostate size did not show any effect on postoperative outcome. While presence of infl ammatory cells in benign prostatic hyperplasia (BPH) histopathology showed positiveeff ect on satisfaction (BPH alone = 47%, BPH + infl ammation = 71%) p value = 0.037, and a protective eff ect on postoperative complications (BPH alone = 45%, +BPH with infl ammation = 18%) p value = 0.167. Conclusion: Retention rate is comparable to the international reports. The presence of infl ammatory cells in the benign prostatic hyperplasia histopathology showed a positive eff ect on postoperative satisfaction.
Extended lipid profile in Romanian ischemic stroke
patients in relation to stroke severity and outcome:
a path analysis model
Authors: Hutanu Adina , Iancu Mihaela , Dobreanu Minodora , Oprea Oana , Barbu Stefan , Maier Smaranda , Tero-Vescan Amelia , Bajko Zoltan , Balasa Rodica 
Published: November 2019

IntroductionOur aim was to evaluate the extended lipid profile in ischemic stroke patients and the relationship with stroke type, severity and outcome.Material and methodsWe prospectively enrolled 124 ischemic stroke patients and 40 healthy controls; baseline plasma and erythrocyte membrane fatty acids concentrations and common lipid profile were analysed. Stroke severity was evaluated by NIHSS on admission, while the functional outcome was defined by mRS at discharge and after 3 months.ResultsTotal cholesterol, triglycerides, HDL-cholesterol, DHA, adrenic, stearic and lauric acid were all lower in patients, taking into account that 87.7% of patients did not receive statins before admission. There was a different pattern in plasma and erythrocyte membrane of fatty acids between patients and controls, also omega-3 index was significantly lower in patients. Patients with poor outcome without statins had significantly lower triglyceride (p = 0.028), while the total cholesterol levels were significantly lower in patients with poor outcome (p = 0.03) but with treatment initiated after admission. Bivariate analysis revealed that patients with poor outcome had significantly lower triglyceride levels regardless the statins use, while the total cholesterol and HDL-cholesterol levels were significantly lower in patients with poor outcome under statin treatment. The long-term outcome were positively influenced by age (β̂ = 0.22, p = 0.001), and NIHSS score at admission (β̂ = 0.55, p < 0.001), and negatively by cholesterol levels (β̂ = –0.17, p = 0.031).ConclusionsDHA, adrenic, stearic and lauric acid were lower in stroke patients; plasma adrenic acid was consumed during the acute phase. The most important predictors for long-term outcome was NIHSS at admission followed by age and total cholesterol.
The role of HOTAIR/miR-152-3p/LIN28B in regulating the progression of endometrial squamous carcinoma
Authors: Li Hao , Liu Dan , Liu Liping , Huang Sanxiu , Ma Aiping , Zhang Xiaohong 
Published: November 2019

IntroductionThere is growing evidence that long non-coding RNAs (lncRNAs) are correlated with malignancy in the modulation of tumor progression. This study aims to investigate the effect of homeobox protein (HOX) transcript antisense RNA (HOTAIR) on the migration and invasion of ESC.Material and methodsStarbase was used to identify miRNAs with complementary base pairing with HOTAIR. RNA pull-down and qRT-PCR were employed to investigate the effect of HOTAIR on miR-152-3p. In vitro cell migration and invasion assays were performed to assess the effects of HOTAIR and miR-152-3p on ESC. Computational software, TargetScan, was then used to identify the potential target of miR-152-3p, and their relationship was verified by immunoblotting analysis, qRT-PCR and luciferase reporter assay.ResultsStarbase predicted a potential miR-152-3p binding site in HOTAIR, which was validated by RNA pull-down assay. HOTAIR was negatively correlated with miR-152-3p in ESC. Moreover, HOTAIR promoted migration and invasion of ESC. The oncogenic activity of HOTAIR was partly through its negative regulation of miR-152-3p. LIN28B was identified to be a direct target of miR-152-3p. A negative correlation between LIN28B and miR-152-3p was observed in ESC. In addition, overexpression of miR-152-3p suppressed the progression of ESC by directly targeting and regulating LIN28B.ConclusionsOur results reveal that HOTAIR may be a driver of ESC through inhibiting miR-152-3p, a tumor suppressor, suggesting that miR-152-3p may be a potential target for advanced ESC therapeutic treatment.
Long non-coding RNA GASL1 inhibits proliferation and invasion of osteosarcoma cells via modulation of the PI3K/Akt pathway
Authors: Gao Feng , Xu Feng 
Published: November 2019

IntroductionStudies have shown long non-coding RNAs to be involved in a wide array of cancer-related processes. This study analyzed the role of LncRNA GAL1 in osteosarcoma cancer proliferation, migration and invasion of cancer cells.Material and methodsThe qRT-PCR technique was used to determine the expression of GASL1. MTT assay was performed for analysis of cell viability. Migration of cancer cells was monitored by wound healing assay. Transwell assay was used for analysis of cancer cell invasion. Western blotting was performed for determination of protein expression levels.ResultsThe results showed that GASL1 exhibits lower expression in osteosarcoma tissues and cell lines than normal surroundings tissues and osteoblasts respectively. GASL1 overexpression resulted in a decline of cancer cell viability as revealed by MTT and colony formation assays. The migration and invasion of cancer cells decreased remarkably when GASL1 was overexpressed in cancer cells. GASL1 over-expression also affected the Bax/Bcl-2 ratio and promoted cell apoptosis. The anticancer effects of GASL1 overexpression were found to be mediated via the PI3K/Akt signaling pathway. GASL1 was seen to play an inhibitory role in PI3K and Akt phosphorylation.ConclusionsLong ncRNA GASL1 inhibits the growth of osteosarcoma cancer cells. Cell apoptosis was promoted via inactivation of the PI3K/Akt signaling pathway. Taken together LncRNA GAL1 may prove to be a beneficial therapeutic target in the treatment of osteosarcoma.
Edaravone attenuates neuronal apoptosis in hippocampus of rat traumatic brain injury model via activation of BDNF/TrkB signaling pathway
Authors: Ding Yuexia , Zhu Wei , Kong Wei , Li Tuo , Zou Peng , Chen Hongguang 
Published: November 2019

IntroductionThe purpose of our study was to explore the effects of edaravone on rats with traumatic brain injury (TBI) and investigate the underlying mechanism.Material and methodsAll rats were separated randomly into 3 groups as follows: sham group (n = 25), TBI group (n = 25), TBI + edaravone group (n = 25). Edaravone was administered intraperitoneally (i.p.) at a dose of 3 mg/kg at 30 min, 12 h, and 24 h after TBI. The neurological impairment and spatial cognitive function were assessed by the neurologic severity score (NSS) and Morris water maze (MWM), respectively. Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to determine the expression levels of caspase-3, B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein (Bax), brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB). Transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay as well as flow cytometry assay was used to determine the apoptosis rate of cells.ResultsEdaravone administration significantly attenuated neurological impairment induced by TBI and promoted cognitive function outcome. The expression of BDNF and TrkB was elevated with treatment of edaravone, which was increased after TBI. The expression of apoptosis related proteins such as caspase-3 and Bax-2 was decreased while that of Bcl-2 was enhanced with edaravone administration following TBI. In addition, edaravone treatment reduced TBI-induced cell apoptosis in the hippocampus.ConclusionsOur study showed that administration with edaravone was able to inhibit neuronal apoptosis in the hippocampus in a rat TBI model. The neuroprotective function of edaravone may relate to modulation of the BDNF/TrkB signaling pathway.
The role of NF-κB and Smac/DIABLO proteins in the treatment response and survival of acute myeloid leukemia patients
Authors: Pluta Agnieszka , Robak Tadeusz , Cebula Barbara , Majchrzak Agata , Pluta Piotr , Brzozowski Kamil , Stępka Konrad , Szmigielska-Kapłon Anna , Grzybowska-Izydorczyk Olga , Czemerska Magdalena , Smolewski Piotr , Wierzbowska Agnieszka 
Published: November 2019

IntroductionThe misbalance between a family of inhibitor of apoptosis proteins (IAP), regulated by the nuclear factor kappa B (NF-κB) and their natural antagonist second mitochondrial-derived activator of caspases/direct IAP binding protein with low pI (Smac/DIABLO) are important to biology of acute myeloid leukemia (AML).Material and methodsThe aim of the study was to assess NF-κB and Smac/DIABLO proteins expression in blasts of 109 newly diagnosed AML patients using the multicolor flow cytometry and evaluate their influence on AML patients outcome.ResultsExpression of NF-κB and of Smac/DIABLO proteins were found in 95% and 98% of the patients, respectively. A negative correlation between Smac/DIABLO and NF-κB was observed. Age < 60 years old as well as higher Smac/DIABLO expression were associated with a higher probability of complete response achievement in the multivariate analysis. Longer overall survival (OS) in the univariate and multivariate analyses was influenced by age < 60 years old, a favorable or intermediate-risk karyotype and high Smac/DIABLO expression. Additionally, in the survival analysis of the subgroups, the patients aged < 60 years old, with high Smac/DIABLO expression, lower NF-κB expression and < 50% of bone marrow blasts who were treated with standard treatment had better OS.ConclusionsLower NF-κB and higher Smac/DIABLO expression may influence AML patients outcome.
How about a ghostwriter writing a deleted scene for an offscreen character?
Authors: Beumer Karina , Lemmens Peter 
Published: November 2019

Abstract
In een film van Woody Allen zien we een eenvoudig straatbeeld in New York. Het lijkt een tussenshot, bedoeld om van de ene scène naar de volgende te gaan en continuïteit te bewaren. De dialoog die we horen, lijkt buiten beeld plaats te vinden. Maar dan blijft de camera langer filmen dan verwacht. De breuk tussen geluid en beeld valt plots weg, wanneer duidelijk wordt dat deze dialoog gevoerd wordt door twee personages die reeds van ver kwamen aanlopen. Midden in het beeld, maar toch off-screen. Alles wat buiten beeld was, lijkt nu plots opnieuw tot de film te kunnen behoren. Een reeks tekeningen schetst deze scène opnieuw tot een storyboard. Dit decor is gebaseerd op filmbeelden van dezelfde locatie, maar dan 42 jaar later. Wat als er weer een stem opduikt die zich niet richt tot de kijker, maar tot iemand die zich ook buiten het kader bevindt? Wat zou er in de marges van het werk kunnen gebeuren, mocht het werk ook nog buiten het beeld verder gaan?
Teken onder weerstand: Over de tekenpraktijk van Matthew Barney en Michelangelo
Authors: Schraeyen Senne 
Published: November 2019

Abstract
Net zoals een kunstenaar als Michelangelo Buonarroti (1476 – 1564) zich profileerde als beeldhouwer, schilder, architect en poëet, laveert Matthew Barney (1967) moeiteloos tussen verschillende hedendaagse kunstvormen.
Het oeuvre van de Amerikaanse kunstenaar Matthew Barney bestaat uit performance, fotografie, tekeningen, designobjecten en film. Niet toevallig werd hij in 1989 door een kunstcriticus omgedoopt tot “De Michelangelo van de genitale kunst”. Dit had niet alleen te maken met de vele naakte atletische lichamen in zijn oeuvre. De verwantschap tussen Barney (1967) en Michelangelo (1476–1564) is groter dan men zou verwachten. Senne Schrayen trekt in dit artikel een parallel tussen de lopende performancereeks Drawing Restraint (gestart in 1987) van Barney en de presentatietekeningen van Michelangelo uit 1532 vanuit een transhistorische invalshoek en met aandacht voor het maakproces van de tekeningen.
Hydro-meteorological reconstruction and geomorphological impact assessment of the October 2018 catastrophic flash flood at Sant Llorenç, Mallorca (Spain)
Authors: Lorenzo-Lacruz Jorge , Amengual Arnau , Garcia Celso , Morán-Tejeda Enrique , Homar Víctor , Maimó-Far Aina , Hermoso Alejandro , Ramis Climent , Romero Romualdo 
Published: November 2019

Abstract. An extraordinary convective rainfall event, unforeseen by most numerical weather prediction models, generated a devastating flash flood (305 m3 s−1) in the town of Sant Llorenç des Cardassar,
Mallorca, on 9 October 2018. Four people died inside this village, while
casualties were up to 13 over the entire affected area. This extreme event
has been reconstructed by implementing an integrated flash flood modelling
approach in the Ses Planes catchment up to Sant Llorenç (23.4 km2), based on three components: (i) generation of
radar-derived precipitation estimates, (ii) modelling of accurate discharge
hydrographs yielded by the catchment (using FEST and KLEM models), and (iii) hydraulic simulation of the event and mapping of affected areas (using HEC-RAS). Radar-derived rainfall estimates show very high agreement with rain gauge data (R2=0.98). Modelled flooding extent is in close agreement with the observed extension by the Copernicus Emergency Management Service, based on Sentinel-1 imagery, and both far exceed the extension for a 500-year return period flood. Hydraulic simulation revealed that water reached a depth of 3 m at some points, and modelled water depths highly correlate (R2=0.91) with in situ after-event measurements.
The 9 October flash flood eroded and transported woody and abundant sediment debris, changing channel geomorphology. Water velocity greatly increased at bridge locations crossing the river channel, especially at those closer to the Sant Llorenç town centre. This study highlights how the very low predictability of this type of extreme convective rainfall events and the very short hydrological response times typical of small Mediterranean catchments continue to challenge the implementation of early warning systems, which effectively reduce people's exposure to flash flood risk in the region.
Establishing cleft services in developing countries: Complications of cleft lip and palate surgery in rural areas of Indonesia
Authors: Ruslin Muhammad , Dom Lawrence , Tajrin Andi , Hajrah Yusuf Andi Sitti , Arif Syafri Kamsul , Tanra Andi Husni , Ou Keng Liang , Forouzanfar Tymour , Thamrin Sri Astuti 
Published: November 2019

Background Cleft treatment is frequently performed in Indonesia, mostly in charity missions, but without a postoperative protocol it is difficult to establish the risks and complications of cleft treatment. The present study was designed to give an overview of current cleft lip and palate treatment strategies in Indonesia and to assess the complication rates during and after surgery.
Methods This prospective study evaluated anesthetic, intraoperative surgical, and short-term postoperative complications in patients undergoing primary, secondary, or corrective surgery for cleft lip and palate deformities. The population consisted of 98 non-syndromic cleft patients. The main anesthetic complication that occurred during general anesthesia was high blood pressure, whereas the main intraoperative surgical complication was excessive bleeding and the main early postoperative complication was extremely poor wound hygiene.
Results In this study, there were no cases of perioperative or postoperative mortality. However, in 23 (23.4%) of the 98 operations performed, at least one perioperative complication related to anesthesia occurred. The intraoperative and early postoperative complications following cleft lip and/or palate were assessed. There was a significant difference in the complication rate between procedure types (χ
2=0.02; P<0.05). However, no relationship was found between perioperative complications related to anesthesia and the occurrence of postoperative complications (χ
2=1.00; P>0.05). Nonetheless, a significant difference was found between procedure types regarding perioperative complications and the occurrence of postoperative complications (χ
2=0.031; P<0.05).
Conclusions Further evaluation of these outcomes would help direct patient management toward decreasing the complication rate.
Simultaneous two-layer harvesting of scalp split-thickness skin and dermal grafts for acute burns and postburn scar deformities
Authors: Oh Suk Joon 
Published: November 2019

Background The scalp, an excellent donor site for thin skin grafts, presents a limited surface but is rich in stem cells. The purpose of this study was to test a double harvesting procedure from the scalp and to evaluate the capacity of the dermal layer.
Methods Two layers corresponding to a split-thickness skin graft (SSG) and a split-thickness dermal graft (SDG) were harvested from the scalp using a Zimmer dermatome during the same procedure. Healing of the scalp donor site, reason for recipient site grafting, and the percentage of graft loss were evaluated.
Results Fourteen patients, comprising six men and eight women with a mean age of 34.2 years, were treated according to our protocol. The most common reason for a recipient site graft was a postburn scar deformity (10/14 patients). The mean area of scalp SSGs was 151.8 cm2. The mean area of scalp SDGs was 88.2 cm2. The mean healing time of scalp donors was 9.9 days. The only donor complication was a tufted scar deformity.
Conclusions Skin defects in the scalp of donors healed faster and led to less scarring than defects at other donor sites. Scalp SDGs needed 10 days for adequate epithelization. The scalp was the best donor site for SSGs and SDGs for burn reconstructive patients.
Early outcomes of cleft and palatal width following anterior palate repair (vomerine flap) in infants with wide cleft lip and palate
Authors: Mat Saad Arman Zaharil , Chai Koh Siang , Wan Sulaiman Wan Azman , Mat Johar Siti Fatimah Noor , Halim Ahmad Sukari 
Published: November 2019

Background Anterior palatal repair performed during cleft lip repair using a vomerine flap may assist in recruiting additional soft tissue for subsequent completion of palatoplasty, especially in patients with a wide cleft. We present our early results in the hope of triggering a re-evaluation of this technique regarding its advantages for maxillary growth through further studies of patients with a wide cleft.
Methods A retrospective analysis of patients with complete unilateral and bilateral cleft lip and palate was performed, including cleft and palatal measurements taken during initial surgery (lip repair together with anterior palate repair) and upon completion of palatoplasty.
Results In total, 14 patients were included in this study, of whom nine (63.3%) had unilateral cleft lip and palate and five (37.5%) had bilateral cleft. All patients had a wide cleft palate. Lip and anterior palate repair was done at a median age of 3 months, while completion of palatoplasty was done at a median age of 10.5 months. Measurements taken upon completion of palatoplasty showed significant cleft width reduction in the mid-palate and intertubercle regions; however, the palatal arch distances at nearby landmarks showed non-significant marginal changes.
Conclusions Anterior palate repair using a vomerine flap significantly reduced the remaining cleft width, while the palatal width remained. Further research is warranted to explore the long-term effects of this technique in wide cleft patients in terms of facial growth.
A simple clinical assessment of breast animation deformity following direct-to-implant breast reconstruction
Authors: Dyrberg Diana Lydia , Gunnarsson Gudjon Leifur , Bille Camilla , Sørensen Jens Ahm , Thomsen Jørn Bo 
Published: November 2019

Background A high incidence of breast animation deformity (BAD) has been reported following immediate breast reconstruction with subpectorally placed implants. The aim of this study was to assess and compare the incidence of BAD in women who underwent either subpectoral or prepectoral immediate breast reconstruction. Therefore, we developed a grading tool and tested its reproducibility in a clinical setting.
Methods Video recordings of 37 women who had undergone unilateral or bilateral immediate breast reconstruction were evaluated by two consultant plastic surgeons. The degree of BAD was assessed by our grading tool, named the Nipple, Surrounding Skin, Entire Breast (NSE) grading scale, which evaluates the degree of tissue distortion in three areas of the breast. Blinded assessments were performed twice by each observer.
Results Eighteen patients were reconstructed with subpectoral implant placement and 19 with prepectoral implant placement. Using the NSE grading scale, we found a significant difference in the degree of BAD between the groups, in favor of patients who underwent prepectoral immediate breast reconstruction (0.2 vs. 4, P=0.000). Inter- and intraobserver agreement was moderate (74%) to strong (88%).
Conclusions The incidence and severity of BAD was significantly lower in women reconstructed with a prepectorally placed implant than in those who underwent subpectoral immediate breast reconstruction. All patients reconstructed using the subpectoral technique had some degree of BAD. The inter- and intraobserver agreements were high when using the NSE grading scale, suggesting it is an easy-to-use, reproducible scale for assessing BAD in women who undergo immediate breast reconstruction.