bluuebunny/crossref_metadata_2025_split huggingface dataset:
To frame or not to frame: creating a metaliteracy course for online Ed.D. students
Authors: Atkinson Melissa D. 
Published: February 2020

Purpose
The purpose of this study is to create a course in a learning management system (LMS), Canvas, for online Ed.D. students and determine if the course can improve scores measuring metaliteracy concepts from pretest to posttest. The course assessed knowledge of metaliteracy goals and objectives instead of using the ACRL Framework. This paper reports on the creation of the course, results of the pretest-posttest, a mapping of metaliteracy goals and objectives with the ACRL Framework and recommendations for including metacognitive practices in library instruction.

Design/methodology/approach
The researcher used a quantitative, quasi-experimental, exploratory design and developed a metaliteracy course in the Canvas LMS using a pretest-posttest design, creating video tutorials as the treatment for each module (five total) using Adobe Spark.

Findings
According to a t-test run in SPSS, there was a significant difference between the metaliteracy pretest and metaliteracy posttest. Using metaliteracy goals and objectives as a method for assessing information literacy knowledge can be useful. Using the ACRL Framework along with metaliteracy goals and objectives can be effective for presenting and assessing information literacy knowledge and skills.

Research limitations/implications
One limitation of this study was the use of one population of online Ed.D. students at one institution. One implication of this study is the need for metaliteracy goals and objectives to be used in connection with the ACRL Framework.

Originality/value
This research adds to the limited knowledge of how metaliteracy goals and objectives can be used to assess information literacy and other literacies using a pretest-posttest format in an online format.
Opium poppy capsule growth and alkaloid production is constrained by shade during early floral development
Authors: Hope Elliana , Carins‐Murphy Madeline R. , Hudson Corey , Baxter Les , Gracie Alistair 
Published: February 2020

AbstractMorphinan alkaloids accumulate in the capsules of Papaver somniferum L. (opium poppy) most likely as defence against herbivory. Thus, capsule size is an important component of alkaloid yield. Shade during early cell division‐dominated growth of reproductive structures generally reduces final fruit size more than shade during later cell expansion‐dominated growth. The current study aimed to determine whether this response is found in opium poppy and the subsequent impact on alkaloid yield, composition and seed production. First the timing of key reproductive developmental events was resolved relative to macromorphological traits. Plants were then shaded during either (a) floral initiation, (b) early floral development or (c) capsule expansion before being harvested at maturation. Shade during floral initiation dramatically reduced final capsule size, alkaloid yield and seed number, and increased the concentration of precursor compounds relative to morphine, despite plants later returning to full sun. Shade during later capsule growth enhanced capsule size and alkaloid yield but had little effect on alkaloid composition or seed number. Thus, early developmental processes, including morphine biosynthesis, appear to have a relatively greater demand for carbohydrates compared with later processes. Crop management practices and environmental factors that limit carbohydrate availability during early development are thus predicted to have significant negative impacts on alkaloid production and reproductive success.
Titration of sevoflurane anesthesia to optimize the time to regain airway reflexes in patients undergoing elective surgery: A randomized clinical trial comparing desflurane and sevoflurane anesthesia
Authors: Arain Shahbaz R. , Yu Sherman , Dugan Shannon , Pagel Paul S. , Ebert Thomas J. 
Published: February 2020

BackgroundDesflurane has adverse environmental effects, but has clinical advantages to speed emergence and return of protective airway reflexes compared with sevoflurane. We hypothesized that weaning of the inspired sevoflurane during the final 15 minutes of surgery would eliminate differences in airway reflex recovery between these agents.MethodsAfter obtaining IRB approval and informed consent, 40 patients undergoing elective surgery (≥1‐hour) randomly received desflurane or sevoflurane. Patients swallowed 20 mL of water without drooling or coughing, and then received sedation and PONV pre‐medication. Anesthesia was induced using propofol and fentanyl and maintained with desflurane or sevoflurane through a laryngeal mask airway maintaining a bispectral index of 45‐50 and 50‐60 during the final 15 minutes before surgery end. Cardiorespiratory variables and age‐adjusted minimal alveolar concentration were recorded. The duration between anesthetic discontinuation and first appropriate response to command was measured; the laryngeal mask airway was removed. Two minutes after responding to command, patients were positioned semi‐upright and attempted to swallow water. If successful swallowing was not achieved, the test was repeated every 4 minutes after each failure until successful swallowing was achieved.ResultsAverage anesthetic concentration and bispectral index was similar in patients receiving desflurane vs sevoflurane. Response times after discontinuation of anesthetics were similar. There were no differences in the recovery of swallowing ability between desflurane and sevoflurane groups.ConclusionWeaning of sevoflurane during the final 15 minutes of surgery eliminates clinical advantages of the more rapid return of airway reflexes with desflurane.
World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom
Authors: Witkiewitz Katie , Heather Nick , Falk Daniel E. , Litten Raye Z. , Hasin Deborah S. , Kranzler Henry R. , Mann Karl F. , O'Malley Stephanie S. , Anton Raymond F. 
Published: February 2020

AbstractAimsTo examine whether World Health Organization (WHO) risk‐level reductions in drinking were achievable, associated with improved functioning and maintained over time among patients at varying initial alcohol dependence severity levels.Design and settingSecondary data analysis of multi‐site randomized clinical trials: the US Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study and the UK Alcohol Treatment Trial (UKATT).ParticipantsIndividuals with alcohol dependence enrolled in COMBINE (n = 1383; 68.8% male) and seeking treatment for alcohol problems in UKATT (n = 742; 74.1% male).InterventionsNaltrexone, acamprosate or placebo, and combined behavioral intervention or medication management in COMBINE. Social behavior network therapy or motivational enhancement therapy in UKATT.MeasurementsWHO risk‐level reductions were assessed via the calendar method. Alcohol dependence was measured by the Alcohol Dependence Scale, the Leeds Dependence Questionnaire and the Diagnostic and Statistical Manual of Mental Disorders. Measures of functioning included alcohol‐related consequences (Drinker Inventory of Consequences and Alcohol Problems Questionnaire), mental health (Short Form Health Survey) and liver enzyme tests.FindingsOne‐ and two‐level reductions in WHO risk levels in the last month of treatment were maintained at the 1‐year follow‐up [adjusted odds ratio (OR), 95% confidence interval (CI) = one‐level reduction in COMBINE: 3.51 (2.73, 4.29) and UKATT: 2.65 (2.32, 2.98)] and associated with fewer alcohol‐related consequences [e.g. B, 95% CI = one‐level reduction COMBINE: –26.22 (–30.62, –21.82)], better mental health [e.g. B, 95% CI = one‐level reduction UKATT: 9.53 (7.36, 11.73)] and improvements in γ‐glutamyltransferase [e.g. B, 95% CI = one‐level reduction UKATT: –89.77 (–122.50, –57.04)] at the end of treatment, even among patients with severe alcohol dependence. Results were similar when abstainers were excluded.ConclusionsReductions in World Health Organization risk levels for alcohol consumption appear to be achievable, associated with better functioning and maintained over time in both the United States and the United Kingdom.
Geographic differences in the distribution of manufacturing firms in Ontario, Canada
Authors: Arku Godwin , Cleave Evan , Easton Megan 
Published: February 2020

For at least the past 20 years, the Province of Ontario – as well as other advanced economic regions – has experienced a period of transition, with traditional manufacturing declining and advanced manufacturing firms and sectors emerging. Concurrently, there has been a concerted policy effort emphasising the development of industry clusters within the province, though key issues of governance and where and how to invest public funds remain. This paper presents research on the spatial configuration of firms in 26 manufacturing sub‐sectors, using point density analysis of the basis for determining the presence and spatial configuration of firms. This allows for the comparison of patterns observed in traditional, advanced, and evolving sub‐sectors. The findings show that there are patterns of clustering in all sub‐sectors, though different spatial configurations are apparent between traditional, advanced, and evolving sub‐sectors. These differences have implications for both investment and governance. Based on the findings, investment needs to be directed towards areas with locational advantages, while regional perspectives and initiatives on cluster governance are needed.
Chronic lymphocytic leukemia and secondary hematological malignancies: A nation‐wide cancer registry study
Authors: Lenartova Andrea , Johannesen Tom Børge , Tjønnfjord Geir Erland 
Published: February 2020

AbstractObjectiveChronic lymphocytic leukemia (CLL) treatment has changed dramatically, and landscape of second hematologic malignancies (SHM) evolves in the new era of targeted therapy. No data were available about the real‐world burden of SHM.MethodsAll 2631 patients with CLL in the Cancer registry of Norway registered 2003‐2012 were included.ResultsAfter median follow‐up of 6.6 years, 103 patients (4%) developed SHM. Diffuse large B‐cell lymphoma (DLBCL) was most common (n = 65; 63%). Median survival was 9.3 years (95% CI; 8.9‐9.8) in non‐SHM patients and 1.7 years in DLBCL, 0.8 years in Hodgkin lymphoma (n = 12), and 2.8 years in myeloid neoplasia (n = 15; 95% CI: 0.3‐2.6, 0.6‐2.9, and 0.4‐5.3, respectively; P < .001). Outcomes were poorest for SHM patients treated for CLL (HR 2.76, 95% CI 1.4‐5.5, P = 0.003). A higher proportion of men and younger age were found in SHM patients (median age 66 vs 72 years in non‐SHM; P < .001; men 68% vs 57%, P = .03). Myeloid neoplasia was rare (incidence rate 1/1000 person‐years; 95% CI: 0.6‐1.5) and tended to occur later than DLBCL in patients treated for CLL (median time from CLL to SHM 62 vs 45 months; P = .09).ConclusionsSHM and especially myeloid malignancies were rare in chemoimmunotherapy era.
Validity of plasma collection cards for ferritin assessment—A proof‐of‐concept study
Authors: Koehler Karsten , Marks‐Nelson Eileen , Braga Camila P. , Beckford Safiya , Adamec Jiri 
Published: February 2020

AbstractObjectivesIron depletion is common around the world and among certain risk groups in developed countries. The overall purpose was to test the suitability of a novel plasma collection card for minimally invasive iron status assessment.MethodsTwenty participants (10 f/10 m) participated in this cross‐sectional study. Ferritin and hemoglobin were measured from blood collected from a forearm vein, serving as reference method. Blood was also collected from the fingertip using the NoviplexTM Plasma Prep Card as well as capillary collection tubes.ResultsThere was substantial concordance between ferritin measured from samples collected via NoviplexTM and venous ferritin (concordance correlation coefficient (CCC) = 0.96) with a mean bias of −0.8 ng/mL. Storing NoviplexTM cards at room temperature for 2 weeks resulted in slightly lower but good concordance when compared to venous ferritin (CCC = 0.95). Capillary hemoglobin (CCC = 0.42) and hematocrit (CCC = 0.25) were in poor agreement with venous data.ConclusionsNoviplexTM cards offer a suitable alternative for a minimally invasive ferritin screening in the field when compared to capillary collection tubes. Despite overall substantial concordance with the reference method, findings indicative of iron status abnormalities should be confirmed in venous samples.
Embryo‐derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate
Authors: Plazibat Milvija , Katušić Bojanac Ana , Himerleich Perić Marta , Gamulin Ozren , Rašić Mario , Radonić Vedran , Škrabić Marko , Krajačić Maria , Krasić Jure , Sinčić Nino , Jurić‐Lekić Gordana , Balarin Maja , Bulić‐Jakuš Floriana 
Published: February 2020

Antiepileptic/teratogen valproate (VPA) is a histone deacetylase inhibitor/epigenetic drug proposed for the antitumor therapy where it is generally crucial to target poorly or undifferentiated cells to prevent a recurrence. Transplanted rodent gastrulating embryos‐proper (primitive streak and three germ layers) are the source of teratoma/teratocarcinoma tumors. Human primitive‐streak remnants develop sacrococcygeal teratomas that may recur even when benign (well differentiated). To screen for unknown VPA impact on teratoma‐type tumors, we used original 2‐week embryo‐derived teratoma in vitro biological system completed by a spent media metabolome analysis. Gastrulating 9.5‐day‐old rat embryos‐proper were cultivated in Eagle's minimal essential medium (MEM) with 50% rat serum (controls) or with the addition of 2 mmVPA. Spent media metabolomes were analyzed by FTIR. Compared to controls, VPA acetylated histones; significantly diminished overall teratoma growth, impaired survival, increased the apoptotic index, and decreased proliferation index and incidence of differentiated tissues (e.g., neural tissue). Control teratomas continued to grow and differentiate for 14 days in isotransplants in vivo, but in vitro VPA‐treated teratomas resorbed. Principal component analysis of FTIR results showed that spent media metabolomes formed well‐separated clusters reflecting the treatment and day of cultivation. In metabolomes of VPA‐treated teratomas, we found elevation of previously described histone acetylation biomarkers [amide I α‐helix and A(CH3)/A(CH2)]) with apoptotic biomarkers within the amide I region for β‐sheets, and unordered and CH2 vibrations of lipids. VPA may be proposed for therapy of the undifferentiated component of teratoma tumors and this biological system completed by metabolome analysis, for a faster dual screening of antitumor/embryotoxic agents.
Structure‐affinity insights into the Na+ and Ca2+ interactions with multiple sites of a sodium‐calcium exchanger
Authors: Iwaki Masayo , Refaeli Bosmat , van Dijk Liat , Hiller Reuben , Giladi Moshe , Kandori Hideki , Khananshvili Daniel 
Published: February 2020

Selective recognition and transport of Na+ and Ca2+ ions by sodium–calcium exchanger (NCX) proteins is a primary prerequisite for Ca2+ signaling and homeostasis. Twelve ion‐coordinating residues are highly conserved among NCXs, and distinct NCX orthologs contain two or three carboxylates, while sharing a common ion‐exchange stoichiometry (3Na+:1Ca2+). How these structural differences affect the ion‐binding affinity, selectivity, and transport rates remains unclear. Here, the mutational effects of three carboxylates (E54, E213, and D240) were analyzed on the ion‐exchange rates in the archaeal NCX from Methanococcus jannaschii and ion‐induced structure–affinity changes were monitored by attenuated total reflection–Fourier‐transform infrared spectroscopy (ATR‐FTIR). The D240N mutation elevated the ion‐transport rates by twofold to threefold, meaning that the deprotonation of D240 is not essential for transport catalysis. In contrast, mutating E54 or E213 to A, D, N, or Q dramatically decreased the ion‐transport rates. ATR‐FTIR revealed high‐ and low‐affinity binding of Na+ or Ca2+ with E54 and E213, but not with D240. These findings reveal distinct structure–affinity states at specific ion‐binding sites in the inward‐facing (IF) and outward‐facing orientation. Collectively, two multidentate carboxylate counterparts (E54 and E213) play a critical role in determining the ion coordination/transport in prokaryotic and eukaryotic NCXs, whereas the ortholog substitutions in prokaryotes (aspartate) and eukaryotes (asparagine) at the 240 position affect the ion‐transport rates differently (kcat), probably due to the structural differences in the transition state.
Dorsal onlay urethroplasty using lingual mucosal grafts for lichen sclerosis anterior urethral strictures repair: Long‐term outcomes
Authors: Aldaqadossi Hussein Abdelhameed , Eladawy Mahmoud , Shaker Hossam , Kotb Youssof , Elgamal Samir , Azazy Samir 
Published: February 2020

ObjectiveTo evaluate the long‐term outcomes of dorsal onlay urethroplasty using lingual mucosal graft for repairing urethral strictures associated with genital lichen sclerosis.MethodsThis study included 36 patients who had lichen sclerosis long anterior urethral strictures that were managed with dorsal onlay urethroplasty using lingual mucosal graft, and were followed up ≥5 years. Preoperatively, we measured the maximum urinary flow rate and the International Prostate Symptom Score, then every 3 months in the first year, and annually thereafter. During follow up, patients with obstructive symptoms were subjected to urethrography and/ or urethroscopy. A successful urethroplasty was defined as normal voiding and no need for further intervention.ResultsOf the 36 patients, two were lost during the follow up, thus 34 patients were involved in the assessment. After lingual mucosal graft urethroplasty, there were significant improvements in maximum urinary flow rate and International Prostate Symptom Score (P < 0.0001). This improvement was sustained during the 5‐year follow‐up period. The median follow‐up period was 66.5 months (interquartile range 64–70 months). The overall success rate in this study was 88.2%. Postoperative complications that required intervention were reported within the first year in four (11.8%) patients. Oral site complications were mild in the early postoperative period with no long‐term complications.ConclusionsDorsal onlay urethroplasty using lingual mucosal graft is a reliable and durable procedure for repairing lichen sclerosis urethral stricture. It provides a long‐term success rate with few failures occurring within the first year. Lingual mucosal graft harvesting is associated with minor, immediate oral complications, and no long‐term morbidity.
Where will the next generation of medical treatments for overactive bladder syndrome come from?
Authors: Michel Martin C 
Published: February 2020

AbstractThis review article discusses the medical need for improved medical treatments of overactive bladder syndrome, and the hurdles and research required to address that need. Currently, few overactive bladder syndrome patients stay on long‐term treatment, largely because efficacy expectations are not met, and tolerability is considered insufficient for the chronic treatment of a non‐life‐threatening condition. Therefore, a medical need exists for improved tolerability and, even more importantly, improved efficacy. It is unlikely that major improvements of efficacy and tolerability can be achieved within the currently approved drug classes. Work in experimental animals suggests that many causes of overactive bladder syndrome exist – each with a distinct pathophysiology. This makes it unlikely that a single medication can address the pathophysiology and treatment needs of all overactive bladder syndrome patients; accordingly, any medication will appear to have only moderate efficacy in the overall group of overactive bladder syndrome patients, even if it fully eliminates symptoms within a subset of patients. It is proposed that only identification of subsets of patients with a defined pathophysiology (and biomarkers thereof) will allow the development and use of targeted treatment that can be highly effective in such subsets.
Food quality of Ephestia eggs, the aphid Rhopalosiphum padi and mixed diet for Orius majusculus
Authors: Toft Søren , Jensen Kim , Sørensen Jesper G. , Sigsgaard Lene , Holmstrup Martin 
Published: February 2020

AbstractWe studied the food quality of the aphid Rhopalosiphum padi to the pirate bug Orius majusculus using Ephestia eggs as high‐quality comparison prey. Several performance parameters were tested on individuals that had been reared and maintained on each of the two single‐prey diets or on a mixed diet. All fitness parameters were lower in individuals fed aphids only, indicating poor food quality of this prey. Compared with the pure Ephestia egg diet, the mixed diet enhanced teneral mass, while adult survival and female starvation tolerance were negatively affected and all other traits were unaffected. Body protein proportions were constant across diets, whereas lipid proportion was low in the aphid treatment. Preference for aphids was lower following a monotypic aphid diet than when reared on Ephestia eggs or a mixed diet. The results confirm that R. padi is low‐quality food for O. majusculus as it is for other generalist predators, even though O. majusculus may contribute significantly to population suppression of the aphid.
Effects of chitosan coatings combined with resveratrol and lysozyme on the quality of Sciaenops ocellatus during refrigerated storage
Authors: Li Yingchang , Zou Qian , Song Suzhen , Sun Tong , Li Jianrong 
Published: February 2020

AbstractThe effects of combined application of lysozyme and resveratrol with chitosan coatings on the quality of Sciaenops ocellatus during refrigerated storage were studied. Physical and chemical indices were periodically analyzed. The chitosan composite coatings were characterized, and the mechanical properties and gas permeability were also measured. The results showed that chitosan coatings could significantly reduce the total viable count (TVC), maintain tissue hardness, chewiness and sensory quality, slow the rate of fat oxidation, and restrain the increases in pH and total volatile basic nitrogen (TVB‐N). Compared with chitosan coatings, the addition of resveratrol and lysozyme had increased the tensile strength and reduced the gas permeability. The lysozyme–resveratrol–chitosan coatings had good preservation properties. The study indicated that the 0.1% lysozyme + 0.2% resveratrol + 1% chitosan group of composite coatings could maintain the quality and extend the shelf life for 8 days compared with the control group during refrigerated storage.