bluuebunny/crossref_metadata_2025_split huggingface dataset:
"A Wearable Ring-shaped Inertial System to Identify Action Planning Impairments During Reach-to-grasp Sequences: A Pilot Study"
Authors: Rovini Erika , Galperti Guenda , Manera Valeria , Mancioppi Gianmaria , Fiorini Laura , Gross Auriane , Robert Philippe , Cavallo Filippo 
Published: December 2020

Abstract
Background. The progressive ageing of the population is leading to an increasing of people affected by cognitive decline, included disorders in executive functions (EFs), such as action planning. Current procedures to evaluate cognitive decline are based on neuropsychological tests, but novel methods and approaches start to be investigated. Reach-to-grasp (RG) protocols have shown that intentions can influence the EFs of action planning.Methods. In this work, we proposed a novel ring-shaped wearable inertial device, SensRing, to measure kinematic parameters during RG and after-grasp tasks with different end-goals. The aim is to evaluate whether SensRing can characterize the motor performances of people affected by Mild Neurocognitive Disorder (MND) with impairment in EFs, named dysexecutive MND (d-MND), compared to older healthy subjects (HC). Ten HC and eight d-MND were asked to reach and grasp a can with three different intentions: to drink (DRINK), to place it on a target (PLACE), or to pass it to a partner (PASS). Twenty-one kinematic parameters have been extracted from SensRing inertial data.Results. Several parameters resulted able to differentiate between HC and d-MND, showing that patients generally have longer reaction times, slower peak velocities and longer deceleration phases. Furthermore, d-MND showed fewer differences among conditions, suggesting that impairments in EFs influence their capabilities into modulating the action planning based on the end-goal.Conclusions. Therefore, the system can be proposed for objectifying the clinical assessment of people affected by d-MND by administering an easy quick motor test. Furthermore, the portability, wearability, accuracy, and ease-of use of the system make the SensRing sytem suitable for remote applications at home, including analysis of protocols for neuromotor rehabilitation in patients affected by MND.
Use of Therapeutic Caffeine in Acute Care Post-operative and Critical Care Settings: a Scoping Review
Authors: Bright Matthew , Raman Vignesh , Laupland Kevin B 
Published: December 2020

Abstract
BackgroundCaffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the peri-operative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and post-operative patients. MethodsPubMed, Embase, CINAHL Complete, Scopus and Web of Science were systematically searched for studies investigating the effects of caffeine withdrawal or administration in ICU patients and in the peri-operative period. Areas of recent systematic review such as pain or post-dural puncture headache were not included in this review. Studies were limited to adults. ResultsOf 2268 articles screened, 26 were included and grouped into two themes of caffeine use in in the peri-operative period and in the ICU. Caffeine withdrawal in the post-operative period increases the incidence of headache, which can be effectively treated prophylactically with peri-operative caffeine. There were no studies investigating caffeine withdrawal or effect on sleep wake cycles, daytime somnolence, or delirium in the intensive care setting. Administration of caffeine results in faster emergence from sedation and anaesthesia, particularly in individuals who are at high risk of post-extubation complications. There has only been one study investigating caffeine administration to facilitate post-anaesthetic emergence in ICU. Caffeine administration appears to be safe in moderate doses in the peri-operative period and in the intensive care setting. ConclusionsAlthough caffeine is widely used, there is a paucity of studies investigating withdrawal or therapeutic effects in patients admitted to ICU and further novel studies are a priority.
Metastasis of Sarcomatoid Malignant Mesothelioma With p16/CDKN2A Deletion Presented as a Subcutaneous Mass in the Back: a Case Report and Review of Literature
Authors: Chen Kai-Bo , Huang Ya-Jing , Huang Yi , Wu Zhi-Wei , Jin Xiao-Li , Zhang Hang , Xiang Xue-Ping , Chen Lin , Chen Li 
Published: December 2020

Abstract
Background: Sarcomatoid malignant mesothelioma (MM) is a rare and aggressive disease, and its diagnosis is challenging.Case presentation: A 60-year-old man was found a recurrent mass in his right back after the initial resection. A chest CT found right pleural thickening, nodular pleural thickening, pleural effusion, mediastinal and right infraclavicular lymph nodes enlargement, which indicated a right pleura MM. Immunohistochemical (IHC) stains of the resected mass showed sarcomatous atypical spindle cells, which were positive for CK 1/3, CK 5/6, WT1, podoplanin and vimentin, and negative for Napsin A, TTF-1 and CDX2, and fluorescent in situ hybridization (FISH) detected homozygous p16/CDKN2A deletion. The association of the chest CT features and the mass assessment confirmed metastatic MM in the subcutaneous layer of the back. Moreover, PET-CT showed multiple metastases in his brain. He developed massive right pleural effusion and chest tightness soon, and the mass kept growing despite of the local and systemic treatments, and he died from pulmonary failure in 3 months.Conclusion: We described an extremely rare subcutaneous metastasis in the back from sarcomatoid MM. And we made the diagnosis by both histological and molecular analysis of the metastatic lesion. MM patients most likely have subcutaneous metastasis on head, they usually develop pleural effusion, chest pain or dyspnea, and their prognosis is very poor because of late diagnosis and insensitivity to current therapies.
Epidemiology, Haematology and Molecular Characterization of Haemoprotozoon and Rickettsial Organisms Causing Infection in Cattle of Jammu Region, North India
Authors: Kaur Rabjot , Yadav Anish , Rafiqi Shafiya Imtiaz , Godara Rajesh , Sudan Vikrant , Chakraborty D , Katoch Rajesh 
Published: December 2020

Abstract
Background: The present study was aimed to establish the prevalence, epidemiology and molecular characterization of major haemoprotozoons (Babesia and Theileria) and rickettsia (Anaplasma) of cattle in Jammu region (North India) using microscopy and Polymerase chain reaction (PCR). Hematology, Microscopy and PCR based prevalence studies were undertaken with 278 blood samples from cattle. Molecular prevalence studies were followed by genetic characterization of the isolates of Babesia, Anaplasma and Theileria spp. based on 18S rRNA, 16S rRNA and Tams1 gene, respectively. The data related to metrology and epidemiological variables like temperature, rainfall, season, age and type of livestock rearing was analyzed and correlated with disease by statistical methods. Results: The study revealed prevalence of Babesia spp., Anaplasma spp. and Theileria spp. to be 14.02%, 23.74% and 1.079% respectively. The metrological and epidemiological variables made inroads for the propagation of vector ticks and occurrence of infection. Haematological alterations predominantly related to haemoglobin, red blood cell count and packed cell volume were evident in diseased animals and collaterally affected the productivity. Further the genetic characterization of Babesia spp. (MN566925.1, MN567603, MN566924.1), Anaplasma spp. (MH733242.1, MN567602.1) and Theileria spp. (MT113479) provided a representative data of the isolates circulating in the region and their proximity with available sequences across the world.Conclusions: Despite holding much significance to the animal sector, comprehensive disease mapping has yet not been undertaken in several parts of India. The present study provides a blue print of disease mapping, epidemiological correlations and genomic diversity of Babesia spp., Anaplasma spp. and Theileria spp circulating in the region.
Colloidal Transport and Deposition Through Dense Vegetation
Authors: Yu Congrong , Duan Peiyi , Yu Zhongbo , Chen Li , Barry D. A. , Sun Yufeng , Li Ying 
Published: December 2020

Abstract
Background
This paper investigates the effectiveness of dense vegetation on removal of colloids, which are important nonpoint source pollutants. In small scale colloid transport experiments, the deposition rate of colloids in dense vegetation is often taken as constant.
Results
This assumption was tested by experiments and modeling aimed at quantifying changes in colloid retention during transport in dense vegetation, in particular how colloid retention changes with travel distance. Flume experiments using a 10-m long dense vegetated strip were conducted under various conditions with combinations of different flow velocities, initial colloid concentrations, solution pH and ionic strength. The advection-dispersion model coupled with first-order deposition kinetics simulated the experimental data satisfactorily.
Conclusions
It showed that the colloid deposition rate decreased with travel distance, with the decline following a power law, and reached steady state after about 10 m. Diffusion and interception processes in colloid filtration theory were sufficient to describe the observed deposition kinetics. The decreasing trend in colloid deposition could be attributed to decreased diffusion along the travel path.
Optimal design and biomechanical simulation analysis of femoral stem based on trabecular bone structure
Authors: Bai Junjun , Feng Yi , Lv Jia , Lv Zhi , Xu Chaojian , Tian Zhi , Wu Zhuangzhuang 
Published: December 2020

Abstract
Background:In orthopaedic clinical treatment, the rigidity mismatch between prosthesis and bone will cause stress shielding phenomenon, affecting bone growth and leading to aseptic loosening and prosthesis failure, and thus a more serious secondary fracture.Purpose:In this paper, the femur stem finite element model of human body standing on one foot and two feet was established, and the biomechanical properties of femur stems with three different structural designs were compared and analyzed, so as to provide theoretical guidance for the structural design and finite element simulation of femur stem.Method: Round-hole femoral stem model and trabecular structural model were established via 3-matic software based on solid femoral stem model. Meshing work was performed by the finite element pre-processing software Hypermesh. The finite element analysis software Abaqus is introduced to analyze the mechanical characteristics of the models for simulating the two different motion conditions of human standing on one foot and on two feet. Results and discussion: The results showed that stress concentration occurred in the femoral neck of all the prostheses with different motion conditions. The stress and displacement values of the three prosthesis models are about twice as much as those of the two-feet models when standing on one foot. The stress and displacement values of the trabecular femoral stem prosthesis were. The stress distribution of femoral stem prosthesis with trabecular bone structure was more uniform, and the force conduction was more obvious, which can effectively reduce the stress shielding effect and was beneficial to the patients’ rehabilitation.
Multi-reference poly-conformational computational methods for de-novo design, optimization, and repositioning of pharmaceutical compounds
Authors: Alexandrov Vadim , Kirpich Alexander , Gankin Yuriy 
Published: December 2020

Abstract
The COVID-19 epidemic, SARS-CoV-2, that began in December of 2019 has drastically altered the aspects of daily life across the global society. Time-effective treatment of those infected has since become a major goal with multiple treatment strategies having been designed to prevent the progression of the disease into severe pneumonia. To date, no drug has been found to be 100% effective against SARS-COV-2, possibly because each candidate drug was targeting only one particular mechanism of action (MoA). Neither proposed up-to-date anti-SARS-COV-2 vaccine are 100% effective. To contribute to the process of finding a more robust small-molecule solution, utilizing several anti-SARS-COV-2 MoAs, a novel framework is presented; where the in silico generated set of virtual library compounds is compared to six known reference drugs: Chloroquine, Favipiravir, Remdesivir, JQ1, Apicidine, and Haloperidol which have been already used for SARS-CoV-2 treatment. The aims were: a) to present a universal search framework for potential candidate compounds based on the comparison of multiple similarities between compounds’ conformers and b) to identify candidate compounds that are simultaneously “close” to each of the six known reference compounds that counteract SARS-CoV-2 via different mechanisms of action.
Characteristics of the Intestinal Microbiota and Metabolism in Infants with Extrauterine Growth Restriction
Authors: Fan Sainan , Zhang Kun , Lv Anping , Ma Yanan , Fang Xiaohui , zhang jinping 
Published: December 2020

Abstract
Objective

Infants with extrauterine growth restriction (EUGR) experience significant postnatal growth restriction in the first week after birth, which indicates a failure of energy absorption. This study aimed to determine the different intestinal microbial species and metabolites between infants with EUGR and those without EUGR.
Methods

A total of 73 infants hospitalized in a neonatal intensive care unit were enrolled and divided into the EUGR group (n = 50) and the non-EUGR group (n = 23). Fecal samples were collected during hospitalization. Bacterial species and their relative abundance were identified with metagenome sequencing. The metabolites in the feces and blood were identified with an LC-MS–based non-targeted metabolome.
Results

The intestinal microbiota of the EUGR group contained less Bacteroides vulgatus, Dorea unclassified, Lachnospiraceae bacterium 1_1_57FAA, and Roseburia unclassified compared to that of the non-EUGR group. More importantly, the intestinal microbiota of the EUGR group contained Streptococcus mitis_oralis_pneumoniae, while that of the non-EUGR group did not. Furthermore, KEGG prediction and a correlation analysis identified that the majority of different microbial species higher in the non-EUGR group were related to metabolism. The results of the non-targeted metabolome revealed that several metabolites in the feces and blood were much higher in either group, some of which were related to the different microbial species.
Conclusions

This study identified several different intestinal microbial species and metabolites in the patients feces and blood, which may provide evidence to identify the biomarkers of infants with EUGR.
Expression levels of plasma exosomal miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p in severe asthma patients and normal individuals with emphasis on inflammatory factors
Authors: Atashbasteh Mostafa , Mortaz Esmaeil , Mahdaviani Seyed Alireza , Jamaati Hamidreza , Allameh Abdolamir 
Published: December 2020

Abstract
BackgroundIdentification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNAs in plasma exosomal fractions severe asthma patients. The expression of the miRNAs was determined in relation to the changes in serum immuno-inflammatory markers.MethodSevere asthma patients (n = 30) and healthy subjects (n = 30) were selected among the individuals referred to the asthma and allergy clinic. Blood was collected from each participant for the estimation of high sensitive C-reactive protein (hs-CRP) and total IgE in serum. The exosomal fraction of plasma was also isolated by ultra-centrifugation and processed for quantitation of miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p expression using quantitative real time-PCR (qRT-PCR).ResultsSerum hs-CRP and total IgE were significantly higher in asthma patients as compared to controls. Expression of miR-124, miR-133b, and miR-130a were down-regulated in asthma patients as compared to controls (p < 0.0001). However, the expression of miR-125b was significantly higher in the patients compared to controls (p < 0.0001). No major changes in miR-125b-1-3p expression was found in the study groups. Data analysis indicated that among the miRNAs, changes in miR-125b in severe asthma patients was highly correlated with the serum levels of hs-CRP and IgE.ConclusionOverexpression of miR-125b that was significantly associated with serum IgE and hs-CRP may suggest that miR-125b is linked to inflammatory reactions in asthma. However, the involvement of miR-124, miR-133b, and miR-130a in asthma complication is ruled out, because they were a poor relationship between these miRNAs and the inflammatory markers.
Short-term Outcomes after Minimally Invasive versus Open Pancreaticoduodenectomy in Elderly Patients: a Propensity Score-matched Analysis
Authors: Yin Shih-min , Liu Yueh-Wei , Liu Yu-Yin , Yong Chee-Chien , Wang Chih-Chi , Li Wei-Feng , Yeh Cheng-Hsi 
Published: December 2020

Abstract
Background:
To date, the evidence on the safety and benefits of minimally invasive pancreatoduodenectomy (MIPD) in elderly patients is still controversy. This study aim to compare the risk and benefit between MIPD and open pancreatoduodenectomy (OPD) in elderly patients.
Methods:
From 2016 to 2020, we retrospective enrolled 26 patients underwent MIPD and other 119 patients underwent OPD. Propensity score matching was applied for old age (≥ 65-year-old) patient analysis. Baseline characteristics, 90-day mortality and short-term surgical outcomes were compared between two groups.
Results:
After 1:2 propensity score matching analysis, elderly patients in MIPD group had significantly poor performance status (P = 0.042) compared to OPD group. Patients receiving MIPD had significantly shorter postoperative hospital stay (POHS) (18 vs. 25 days, P = 0.028), earlier drain removal (16 vs. 21 days, P = 0.012) and smaller delay gastric empty rate (5.9 vs. 32.4% P = 0.036). There was no 90-day mortality (0% vs 11.8%, P = 0.186) and pulmonary complications (0% vs 17.6%, P = 0.075) in MIPD group, and the major complication rate is comparable to OPD group (17.6% vs 29.4%, P = 0.290).
Conclusion:
For elderly patients, MIPD is a feasible and safe option even in patients with inferior preoperative performance status. MIPD might also provide potential advantage for elderly patients in minimizing pulmonary complication and overall mortality over OPD.
Survival Benefit of Intervention Treatment in	Advanced Anaplastic Thyroid Cancer
Authors: KASEMSIRI PORNTHEP , Chaisakgreenon Pimpika , Vatanasapt Patravoot , Laohasiriwong Supawan , Teeramatwanich Watchareeporn , Thongrong Cattleya , Ratanaanekchai Teeraporn , Suetrong Surapol 
Published: December 2020

Abstract
Background

Management of anaplastic thyroid cancer (ATC) is a controversial issue; thus, proper treatment and prognostic factors should be investigated.
Objectives

To compare the survival outcomes of intervention and palliative treatment in ATC patients.
Methods

A hospital-based retrospective study was conducted in a single tertiary university hospital. The medical record charts were retrieved from November 20, 1987 to December 31, 2016. The final follow-up was ended by December 31, 2017. Patients’ demographic data, laboratory data, clinical presentation, and results of treatment modalities were analyzed.
Results

One hundred twenty-one records were analyzed that one-year overall survival rate of 3.5% (median survival time of 77 days); however, there was insufficient data on 16 cases to classify staging and treatment modalities. Therefore 105 ATC patients (37 stage IVa, 39 stage IVb, 29 stage IVc) were included with one-year overall survival rate of 4.0% (median survival time of 82 days). Intervention treatment allowed longer median survival times (p < 0.05) and a better survival rate (p < 0.05). Among the intervention treatment group, post-operative chemoradiation yielded the longest median survival time (187 days) and the longest survival rate (20%) (p < 0.05). At all stages, intervention modality allowed better median survival time, especially in stage IVa (p < 0.05). Unfavorable prognostic factors were adjusted with multiple cox regression model that showed significant factors included age ≥ 65 years (HR of 2.57), palliative treatment (HR of 1.85), and leukocytosis ≥ 10,000/mm3(HR of 2.76).
Conclusions

Intervention treatment provided a better survival outcome in all stages, especially in stage IVa with a significantly better median survival time. Among intervention treatments, postoperative chemoradiation offered the longest survival rate; thus, suggesting this should be considered in ATC patients who have resectable tumors and no poor prognostic factors such as older age and leukocytosis.
Point-of-Care Capillary Blood Creatinine: A Prospective Study In Cardiology and Nephrology Outpatients
Authors: Vilaine Eve , Gabarre Paul , Beauchet Alain , Seidowsky Alexandre , Auzel Olivier , Moreau Marie Hauguel , Dubourg Olivier , Mansencal Nicolas , Essig Marie , Massy Ziad 
Published: December 2020

Abstract
Background: The radiological or interventional use of contrast medium exposes patients to a risk of contrast-induced nephropathy. Pre-existing kidney failure is a major risk factor. Point-of-care capillary (POC) blood creatinine tests are promising; their speed might help to optimize treatment decisions and patient care in these situations. Methods: The objective of the present study was to assess the ability of a new point of care capillary blood creatinine test (Stat Sensor X-press, Nova Biomedical Cooperation, Waltham, MA, USA) to diagnose kidney failure, relative to a standard lab-based plasma creatinine assay. A total of 113 patients 33 women (29.2%) were included. The capillary blood creatinine concentration was significantly correlated with the plasma creatinine concentration in both men (Pearson’s r [95% confidence interval (CI)] = 0.84 [0.75 – 0.89]; p<0.001) and women (Pearson’s r [95%CI] = 0.95 [0.89 – 0.97]; p<0.001). The test’s diagnostic performance was satisfactory, its sensitivity was 70% [35 – 93] in women and 78% [52 – 94] in men, and its specificity was 91% [72 – 99] in woman and 93% [84 – 98] in men. Conclusion: Rapid POC creatinine test is an easy-to-use, accurate tool for detecting kidney failure before a patient is exposed to procedures involving contrast medium.