bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blue and Deep‐Blue‐Emitting Organic Lasers with Top‐Layer Distributed Feedback Resonators
Authors: Bonal Víctor , Villalvilla José M. , Quintana José A. , Boj Pedro G. , Lin Naiti , Watanabe Shoya , Kazlauskas Karolis , Adomeniene Ona , Jursenas Saulius , Tsuji Hayato , Nakamura Eiichi , Díaz‐García María A. 
Published: October 2020

AbstractAll‐solution processed surface‐emitting organic distributed feedback lasers are attractive devices for low‐cost applications. Here, lasers emitting in the spectral region between 375 and 475 nm, in which both active material and resonator (1D relief gratings) are based on solution‐processable polymer films, are reported. Ten different organic compounds dispersed in polystyrene are used as active layers of the prepared devices. They include various carbon‐bridged oligo(p‐phenylenevinylene) (COPVn, with n = 1,2) derivatives and two terfluorene compounds. The synthesis and complete optical and amplified spontaneous emission properties of one of the COPV1 compounds, COPV1(Me)‐t‐Bu, designed for deep‐blue emission, are also included. The feasibility of the resonator fabrication, performed by holographic lithography with a dichromated gelatine photoresist over the active film, is successfully demonstrated for all devices. Remarkably, no resolution limitations are found even for the lowest grating period (235 nm) required for the fabrication of the laser based on COPV1(Me)‐t‐Bu. It is also demonstrated that the rectangular grating profile with duty cycle 0.75:0.25 (hill:valley) is very convenient to optimize the resonator efficacy.
Sunlight‐Driven Self‐Organized Helical Superstructure Chromotropic Device
Authors: Wang Qian , Yu Li , Sun Jian , Guan Yu , Zhou Ziyuan , Shin Yunho , Yang Huai , West John , Yang Deng‐Ke 
Published: October 2020

AbstractSunlight‐driven chromotropic devices have attracted much attention and been intensively studied in recent years because of their applications in the fields of soft robotics, camouflage, and anti‐counterfeiting. Herein, a sunlight‐driven helical superstructure chromotropic device is reported via doping a photo‐responsive molecular motor molecule into the nematic liquid crystal host to form cholesteric liquid crystals (CLCs). In designed CLC chromotropic devices, the color changing range is capable of covering the visible region upon exposure to sunlight of different intensities. The photo‐responsive behaviors of the CLC chromotropic devices, including initial state, photo‐stable state, and transforming mode can be accurately controlled by manipulating their composition. Moreover, it is feasible to mass produce CLC chromotropic devices in various forms from rigid to soft and from film to fiber. They are demonstrated as smart “skins” capable of imitating the colors of surrounding environments. Their rewritable feature under sunlight offers a promising platform for designing and fabricating advanced multifunctional devices for real‐world applications.
Soft Lithography for Manufacturing Scalable Perovskite Metasurfaces with Enhanced Emission and Absorption
Authors: Kessel Amit , Frydendahl Christian , Indukuri Sita Rama Krishna Chaitanya , Mazurski Noa , Arora Pankaj , Levy Uriel 
Published: October 2020

AbstractOrganic–inorganic hybrid perovskites have emerged in recent years as a promising alternative to silicon solar cells and other optoelectronic devices, mostly due to their high photon yields, long carrier lifetime, adjustable bandgap, and other merits. While patterning photonic nanostructures onto their inorganic counterparts is well established to augment their capabilities, lack of compatibility with conventional lithography techniques hinders the implementation of those principles with perovskites. Hereby, the fabrication of MAPbI3 nanophotonic structures such as nanoscale metasurfaces is demonstrated via soft lithography, a method in which the patterning is done when the perovskite is not fully crystallized, allowing for crystallization within the mold with the end result of facile and unharmful imprinting of sub‐micron features onto perovskite thin films, over large areas and with the potential to scale up in a seamless way. By doing so, a substantial increase in light absorption as well as twofold photoluminescence enhancement from the perovskite thin film is shown. These results are supported by spectral and lifetime measurements. This method is pertinent to many device configurations and can assist in realizing the future of high‐efficiency perovskite‐based devices, including solar cells, LEDs, lasers, and more.
Human recombinant lysosomal β‐Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay‐Sachs fibroblasts
Authors: Espejo‐Mojica Angela J. , Rodríguez‐López Alexander , Li Rong , Zheng Wei , Alméciga‐Díaz Carlos J. , Dulcey‐Sepúlveda Cindy , Combariza Germán , Barrera Luis A. 
Published: October 2020

AbstractGM2 gangliosidosis, Tay‐Sachs and Sandhoff diseases, are lysosomal storage disorders characterized by the lysosomal accumulation of GM2 gangliosides. This accumulation is due to deficiency in the activity of the β‐hexosaminidases Hex‐A or Hex‐B, which are dimeric hydrolases formed by αβ or ββ subunits, respectively. These disorders show similar clinical manifestations that range from mild systemic symptoms to neurological damage and premature death. There is still no effective therapy for GM2 gangliosidoses, but some therapeutic alternatives, as enzyme replacement therapy, have being evaluated. Previously, we reported the production of active human recombinant β‐hexosaminidases (rhHex‐A and rhHex‐B) in the methylotrophic yeast Pichia pastoris. In this study, we evaluated in vitro the cellular uptake, intracellular delivery to lysosome, and reduction of stored substrates. Both enzymes were taken‐up via endocytic pathway mediated by mannose and mannose‐6‐phosphate receptors and delivered to lysosomes. Noteworthy, rhHex‐A diminished the levels of stored lipids and lysosome mass in fibroblasts from Tay‐Sachs patients. Overall, these results confirm the potential of P. pastoris as host to produce recombinant β‐hexosaminidases intended to be used in the treatment of GM2 gangliosidosis.
Engaging Perioperative Learners Using Online Game‐Based Education
Authors: Crowley-Barnett Jennifer , Pagano Teresa , Kent Martha 
Published: October 2020

ABSTRACTNurse educators may experience challenges (eg, distracted learners, inability to provide immediate feedback) when teaching in a classroom setting. Further, the perioperative workforce is multigenerational—younger staff members may have started using technology on a daily basis at a young age, so they may become distracted during traditional lectures and not retain important information. Online game‐based learning (GBL) platforms are one technological solution that perioperative educators can use to maintain student engagement and foster learning. Educators at an academic medical center used an online GBL platform to develop presentations on instrument sterilization and surgical attire with sterile technique. At the conclusion of the sessions, the participants submitted surveys evaluating the teaching method. The survey results showed that the respondents found the GBL program to be a fun and positive interactive learning experience. Nurse educators should consider using this type of technology to improve participation and knowledge retention when developing educational programs.
Study on the friction properties of nanocopper oxide/fluorosilicone rubber
Authors: Yang Xiaoping , Tian Jianfeng , Dong Jun 
Published: October 2020

AbstractIn order to study the effect of nanocopper oxide (n‐CuO) on the friction properties of fluorosilicone rubber (FVMQ), the mechanical blending method was used by adding n‐CuO in preparation of FVMQ. Characterization of scanning electron microscopy, X‐ray diffraction analysis, energy dispersive spectroscopy, and so on were utilized for studying the mechanism of n‐CuO in FVMQ. The experimental test on tensile, tear, and friction performance were performed on n‐CuO/FVMQ at both room temperature (RT) and 200°C. In comparison with n‐CuO /FVMQ, the wear depth of FVMQ increased by 52.933 and 5.605 μm for RT and 200°C, respectively. Besides, the wear loss of FVMQ increased by 2.9 and 5.3 mg, respectively. The results show that for both at RT or 200°C, the addition of n‐CuO changes the friction mechanism of FVMQ. The friction coefficient and wear loss of FVMQ are effectively reduced, so that the friction property of rubber matrix is significantly enhanced. In addition, the tearing property of FVMQ is improved by adding n‐CuO to change the crosslinking density of FVMQ.
Macrostructure of anisotropic shape memory polymer films studied by the molecular probe method
Authors: Kondratov Alexander P. , Cherkasov Egor P. , Paley Vladislav , Volinsky Alex A. 
Published: October 2020

AbstractAn anisotropic copolymer film of vinyl chloride and vinyl acetate, which has shape memory properties, was investigated by the molecular probe method, thermomechanical analysis, and scanning calorimetry. It was found that the amorphous‐crystalline structure and the stress–strain state of the surface layer of the film differ from the structure and state of the inner layers. The molecular probe (limited diffusion of a solvent into the surface layer of the film) revealed the localization of the elastic deformation energy of a film, which was rapidly cooled in a stressed state during production. It is shown that destroying/crushing the stressed macrostructure of the film surface via plasticization and dissolution of the copolymer, eliminates the effects of the elastic energy release during thermally stimulated shrinkage.
Wettability behavior of solution blow spun polysulfone by controlling morphology
Authors: Domínguez José E. , Kasiri Ali , González‐Benito Javier 
Published: October 2020

AbstractSolution blow spinning (SBS) is used to prepare polysulfone materials (PSf) with different morphologies changing the processing conditions. Morphological study is done by scanning electron microscopy. Materials mainly constituted by beads and fibers are obtained. An optimization strategy based on desirability function approach together with Box–Behnken design is employed to find the best processing conditions to produce PSf materials with tailored morphology. Feed rate and air pressure are the variables of SBS processing conditions with the highest influence on the relative amount of fibers produced while air pressure and a particular balance between work distance and feed rate have the highest impact on the size of fibers. Contact angle measurements are used to understand SBS PSf wettability as a function of morphology. It is demonstrated the possibility of designing PSf materials with particular wettability behavior induced by tailored morphologies obtained from a particular election of SBS processing conditions.
Identifying environmental risk factors and gene–environment interactions in holoprosencephaly
Authors: Addissie Yonit A. , Troia Angela , Wong Zoe C. , Everson Joshua L. , Kozel Beth A. , Muenke Maximilian , Lipinski Robert J. , Malecki Kristen M.C. , Kruszka Paul 
Published: October 2020

AbstractBackgroundHoloprosencephaly is the most common malformation of the forebrain (1 in 250 embryos) with severe consequences for fetal and child development. This study evaluates nongenetic factors associated with holoprosencephaly risk, severity, and gene–environment interactions.MethodsFor this retrospective case control study, we developed an online questionnaire focusing on exposures to common and rare toxins/toxicants before and during pregnancy, nutritional factors, maternal health history, and demographic factors. Patients with holoprosencephaly were primarily ascertained from our ongoing genetic and clinical studies of holoprosencephaly. Controls included children with Williams‐Beuren syndrome (WBS) ascertained through online advertisements in a WBD support group and fliers.ResultsDifference in odds of exposures between cases and controls as well as within cases with varying holoprosencephaly severity were studied. Cases included children born with holoprosencephaly (n = 92) and the control group consisted of children with WBS (n = 56). Pregnancy associated risk associated with holoprosencephaly included maternal pregestational diabetes (9.2% of cases and 0 controls, p = .02), higher alcohol consumption (adjusted odds ratio [aOR], 1.73; 95% CI, 0.88–15.71), and exposure to consumer products such as aerosols or sprays including hair sprays (aOR, 2.46; 95% CI, 0.89–7.19). Significant gene–environment interactions were identified including for consumption of cheese (p < .05) and espresso drinks (p = .03).ConclusionThe study identifies modifiable risk factors and gene–environment interactions that should be considered in future prevention of holoprosencephaly. Studies with larger HPE cohorts will be needed to confirm these findings.
Design, Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives Containing Benzoic Acid Group as Potential AKR1C3 Inhibitors
Authors: Sun Mingjiao , Zhou Yi , Zhuo Xuefang , Wang Sheng , Jiang Shisheng , Peng Zhihuan , Kang Ke , Zheng Xuehua , Sun Mingna 
Published: October 2020

AbstractCastration‐resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer, characterized by reactivation of the androgen axis. Aldo‐keto reductase 1C3 (AKR1C3) converts androstenedione (AD) and 5α‐androstanedione to testosterone (T) and 5α‐dihydrotestosterone (DHT), respectively. In CRPC, AKR1C3 is upregulated and implicated in drug resistance and has been regarded as a potential therapeutic target. Here we examined a series of indole derivatives containing benzoic acid or phenylhydroxamic acid and found that 4‐({3‐[(3,4,5‐trimethoxyphenyl)sulfanyl]‐1H‐indol‐1‐yl}methyl)benzoic acid (3e) and N‐hydroxy‐4‐({3‐[(3,4,5‐trimethoxyphenyl)sulfanyl]‐1H‐indol‐1‐yl}methyl)benzamide (3q) inhibited 22Rv1 cell proliferation with IC50 values of 6.37 μM and 2.72 μM, respectively. In enzymatic assay, compounds 3e and 3q exhibited potent inhibitory effect against AKR1C3 (IC50=0.26 and 2.39 μM, respectively). These results indicated that compounds 3e and 3q might be useful leads for further investigation of more potential AKR1C3 inhibitors used for CRPC.
Novel Dioxane and Morpholino Nucleotide Analogues: Syntheses and RNA‐Hybridization Properties
Authors: Hofmeister Armin , Jahn‐Hofmann Kerstin , Krack Arne , Müller Armin , Kurz Michael , Scheidler Sabine 
Published: October 2020

AbstractA novel class of nucleotide analogues with a dioxane ring as central scaffold has been developed. Synthetic routes in two diastereomeric series were realized, and the final thymidine analogues were synthesized with common functionalities for the automated oligonucleotide synthesis. The chemical space of the initially derived nucleotides was expanded by changing the central dioxane to analogous morpholine derivatives. This opens up the possibility for further derivatization by attaching different substituents at the morpholine nitrogen. The novel nucleotide building blocks were incorporated into double‐stranded RNA sequences, and their hybridization properties investigated by melting‐temperature analysis. Both scaffolds, dioxanes and morpholines, had an equal impact on double‐strand stability, but Tm values differed depending on the chirality in the six‐membered ring.
Post‐traumatic growth in prisoners and its association with the quality of staff–prisoner relationships
Authors: Hearn Natalie , Joseph Stephen , Fitzpatrick Sally 
Published: October 2020

AbstractBackgroundBeing sentenced to imprisonment can be traumatic. This may lead to further negative effects, including reoffending or disorders of mental health. Emerging research, however, has suggested that traumatic events can, at times, also lead to post‐traumatic growth, leading us to question whether prisoners could experience this.AimsOur aims were to explore the prevalence of post‐traumatic growth in prisoners and any association between this and prisoners' perceptions of the quality of their relationships with staff. Our primary hypothesis was that there would be a positive association between perceptions of the quality of relationships with staff members and post‐traumatic growth. We also hypothesised an interaction between staff–prisoner relationships and the extent to which sentencing was experienced as traumatic.MethodThe Post‐traumatic Growth Inventory and the Barrett‐Lennard Relationship Inventory were distributed to all 762 prisoners in a high‐security prison for adult men in England. First, one‐tailed correlations between variables were run, then a hierarchical regression analysis was conducted to test for an interaction between staff–prisoner relationship ratings, trauma of sentencing and post‐traumatic growth.ResultsJust over one fifth of the men (n = 160) returned questionnaires; 76 (48%) had scores indicative of moderate‐to‐high post‐traumatic growth. There was a significant positive association between perceptions of the relationships with staff members and the post‐traumatic growth reported. There was no significant interaction between the staff–prisoner relationships and the experience of trauma of imprisonment.ConclusionsOur study extends understanding of prisoners through finding that higher levels of self‐rated post‐traumatic growth were associated with experiencing empathy, positive regard, acceptance and genuineness from prison staff. This highlights the need for high‐quality relationships to be adopted in all aspects of prison setting and culture and offers further direction for research into such relationships and their role in promoting positive psychological outcomes.
Diagnostic approach and arthroscopic treatment of septic arthritis of the knee, in an infant
Authors: Laliotis Nikolaos , Chrysanthou Chrysanthos , Konstandinidis Panagiotis , Giannakopoulou Lambrini 
Published: October 2020

AbstractA 9‐month‐old baby presented with sudden inability to stand and unable to move his leg. Clinical examination showed edema and knee effusion. Blood tests and MRI confirmed septic knee arthritis without bone involvement. He was treated with arthroscopic lavage. He had a complete recovery and normal growth.
Acute pancreatitis in a COVID‐19 patient: An unusual presentation
Authors: Acherjya Goutam Kumar , Rahman Md Masudur , Islam Mohammad Touhidul , Alam ABM Saiful , Tarafder Keya , Rahman Mohammad Mostafizur , Ali Mohammad , Deb Shudip Ranjan 
Published: October 2020

AbstractAny atypical presentation of COVID‐19 may be occurred as a part of its elevated coagulopathy or cytokine storm syndrome. So therefore, physicians should be aware and prepared to handle such atypical presentations and sequelae related to COVID‐19.
Binswanger's disease: Case presentation and differential diagnosis
Authors: Văcăraș Vitalie , Cordoș Adrian Mihai , Rahovan Imelda , Frunze Sorina , Mureșanu Dafin Fior 
Published: October 2020

AbstractEstablishing a diagnosis of Binswanger's disease requires a multimodal approach. As new pathophysiological mechanisms are revealed, tests that should yield greater specificity will become available in the years to come.
Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water
Authors: Hinzmann Alessa , Betke Tobias , Asano Yasuhisa , Gröger Harald 
Published: October 2020

AbstractWhile belonging to the most fundamental functional groups, nitriles represent a class of compound that still raises challenges in terms of an efficient, cost‐effective, general and, at the same time, sustainable way for their synthesis. Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component has been developed and successfully applied for the synthesis of a range of nitrile products. In these biotransformations, the Oxd enzymes catalyze the dehydration of aldoximes as readily available substrates to the nitrile products. Herein, these developments with such enzymes are summarized, with a strong focus on synthetic applications. It is demonstrated that this biocatalytic technology has the potential to “cross the bridge” between the production of fine chemicals and pharmaceuticals, on one hand, and bulk and commodity chemicals, on the other.
Selectivity of Rh⋅⋅⋅H−C Binding in a σ‐Alkane Complex Controlled by the Secondary Microenvironment in the Solid State
Authors: Furfari Samantha K. , Tegner Bengt E. , Burnage Arron L. , Doyle Laurence R. , Bukvic Alexander J. , Macgregor Stuart A. , Weller Andrew S. 
Published: October 2020

AbstractSingle‐crystal to single‐crystal solid‐state molecular organometallic (SMOM) techniques are used for the synthesis and structural characterization of the σ‐alkane complex [Rh(tBu2PCH2CH2CH2PtBu2)(η2,η2‐C7H12)][BArF4] (ArF=3,5‐(CF3)2C6H3), in which the alkane (norbornane) binds through two exo‐C−H⋅⋅⋅Rh interactions. In contrast, the bis‐cyclohexyl phosphine analogue shows endo‐alkane binding. A comparison of the two systems, supported by periodic DFT calculations, NCI plots and Hirshfeld surface analyses, traces this different regioselectivity to subtle changes in the local microenvironment surrounding the alkane ligand. A tertiary periodic structure supporting a secondary microenvironment that controls binding at the metal site has parallels with enzymes. The new σ‐alkane complex is also a catalyst for solid/gas 1‐butene isomerization, and catalyst resting states are identified for this.
Industry‐Driven Rapid Prototyping for Comparing Nonlinear Control Schemes in Pyomo
Authors: Schmid Jochen , Teichert Katrin , Chioua Moncef , Schindler Thorsten , Bortz Michael 
Published: October 2020

AbstractWith ongoing digitalization, fast simulation of process dynamics offers new opportunities for model‐based control schemes. This is eased by the availability of high‐level, open‐access, easy‐to‐use software able to simulate and optimize chemical processes, making rapid prototyping possible also for the chemical engineer. In this study, the capabilities of the Python‐based open‐source software package Pyomo towards industrial application is illustrated in modeling and comparing different control schemes for a simple Williams‐Otto process. It is shown how to simulate the process dynamics and how to compute optimal control trajectories for minimizing waste and maximizing yield. Two approaches to setpoint tracking are compared: one based on proportional‐integral feedback control and one based on optimal open‐loop control.
MinimumLq‐distance estimators for non‐normalized parametric models
Authors: Betsch Steffen , Ebner Bruno , Klar Bernhard 
Published: October 2020

AbstractWe propose and investigate a new estimation method for the parameters of models consisting of smooth density functions on the positive half axis. The procedure is based on a recently introduced characterization result for the respective probability distributions, and is to be classified as a minimum distance estimator, incorporating as a distance function theLq‐norm. Throughout, we deal rigorously with issues of existence and measurability of these implicitly defined estimators. Moreover, we provide consistency results in a common asymptotic setting, and compare our new method with classical estimators for the exponential, the Rayleigh and the Burr Type XII distribution in Monte Carlo simulation studies. We also assess the performance of different estimators for non‐normalized models in the context of an exponential‐polynomial family.