bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leadframe Design Enhancement for Elimination of Burrs at Singulation Process
Authors: Jr. Antonio Sumagpang , Gomez Frederick Ray , Jr. Edwin Graycochea 
Published: August 2020

The paper focused on the improvement done in leadframe design to address the copper (Cu) burrs defect in assembly manufacturing. Newly qualified device struggled to hit the target yield due to the said Cu burrs defect. A holistic approach through why-why analysis was performed by the technical cross-functional team to identify the root-cause and come-up with the robust solution to the issue. The paper discussed how the device in focus was made as point of reference in designing a leadframe carrier. Ultimately, the new and enhanced leadframe design successfully eliminated the occurrence of Cu burrs with 100% improvement in the scrappage rate.
A mulher na brincadeira do Boi-Bumbá de Parintins: no ritmo da exploração e da opressão
Authors: Da Silva Elizandra Garcia 
Published: August 2020

<p class="TtulodeItem"><em>Resumo:</em><em> </em>O objetivo deste estudo é analisar o trabalho da mulher na brincadeira do Boi-Bumbá de Parintins. O método utilizado para analisar os dados extraídos do campo foi o materialismo histórico dialético, por meio do qual evidenciamos, as contradições constituintes do trabalho da mulher na brincadeira de Boi e as discutimos a luz das teorias. E, consideramos haver, na brincadeira de Boi, exploração e opressão da mulher, como mediações próprias do modo de produção capitalista àquela realidade. Logo urge a necessidade de superação desse modal pelo comunista, onde os sujeitos, práticos e sociais, se organizem livremente para produzir suas vidas.</p><p> </p>
Investigações sobre o tema da prática: contribuições de José Barata-Moura para o debate da formação pré-profissional de professores
Authors: Peixoto Elza Margarida de Mendonça 
Published: August 2020

<span>Este artigo apresenta resultados de estudos pós-doutorais relativos ao tema da prática na formação de professores, no sentido de um aprofundamento teórico. Nesta direção, expõe as </span><span>análises</span><span> empreendidas pelo filósofo português José Barata-Moura acerca das “ontologias da prática”. Tais estudos trazem à tona abordagens que, na tentativa de se afastarem do idealismo, sem realizar uma rigorosa crítica dos seus fundamentos, acabam por produzir teorizações recheadas de uma expectativa de <em>posição</em> da realidade pela prática. Finalizamos apontando as demandas abertas pela crítica aos idealismos da prática, entre estas, a revisão crítica dos fundamentos teóricos subjacentes às disciplinas que visam à preparação pré-profissional dos professores.</span>
Chemoselective Ketone Synthesis by the Strontium‐mediated Alkylation or Arylation of N,N‐Dimethylamides or Urea
Authors: Miyoshi Norikazu , Kimura Shodai , Kubo Shigeki , Ohmura Satoshi D. , Ueno Masaharu 
Published: August 2020

AbstractKetone synthesis via the addition of organometallic reagents to amides has long been investigated. In many cases, it is necessary to control the solvent, reaction temperature, and adhere to strict nucleophile stoichiometry for each combination of amide and organometallic reagent. Strontium, with an electronegativity comparable to lithium but a larger ionic radius, may display high reactivity with the characteristics of monoalkylation. Here, we show that the monoalkylation of various N,N‐dimethylamide derivatives with alkyl iodides to afford the ketones proceeds smoothly under generally mild temperature conditions. By this method, not only aromatic amides but also α‐proton‐bearing aliphatic amides were suitable substrates for ketone synthesis. In addition, we found that tetramethylurea, typically a poor electrophile, also reacted to afford benzophenone in good yield with excellent selectivity.
Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status
Authors: Wu Che‐Yuan , Ouk Michael , Wong Yuen Yan , Anita Natasha Z. , Edwards Jodi D. , Yang Pearl , Shah Baiju R. , Herrmann Nathan , Lanctôt Krista L. , Kapral Moira K. , MacIntosh Bradley J. , Rabin Jennifer S. , Black Sandra E. , Swardfager Walter 
Published: August 2020

AbstractIntroductionFew studies have examined memory decline among patients with type 2 diabetes using different oral hypoglycemic drugs.MethodsParticipants with normal cognition (NC) or Alzheimer's disease (AD) dementia using a hypoglycemic medication (2005 to 2019) were identified from the National Alzheimer's Coordinating Center database. Delayed memory was assessed using the Wechsler Memory Scale Revised–Logical Memory test. Associations between oral drug classes and memory over time were examined using mixed‐effects models with inverse probability treatment weights.ResultsIn NC (n = 1192), metformin use was associated with better memory performance over time, whereas in AD (n = 807), dipeptidyl peptidase‐4 (DPP4) inhibitor use was associated with a slower rate of memory decline. Interaction effects suggested greater benefit associated with DPP4 inhibitor use among APOE ε4 carriers.DiscussionAssociations between different oral hypoglycemic drugs and memory change were not consistent between cognitively normal elderly and those with AD dementia. APOE ε4 genotype modified some relationships.
Boron neutron capture therapy: Current status and future perspectives
Authors: Dymova Mayya Alexandrovna , Taskaev Sergey Yurjevich , Richter Vladimir Alexandrovich , Kuligina Elena Vladimirovna 
Published: August 2020

AbstractThe development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large‐scale screening of new, more specific boron delivery agents.
Ireland’s pre‐1940 daily rainfall records
Authors: Ryan Ciara , Murphy Conor , McGovern Rhonda , Curley Mary , Walsh Séamus ,   476 students
Published: August 2020

AbstractThis article presents daily rainfall data and metadata for Ireland transcribed from historical manuscript and printed copies of rainfall registers located in Met Éireann's archives. To facilitate the transcription of rainfall observations from paper records, the historical manuscripts were scanned and integrated into Met Éireann's digital archives. The transcription from digital image to data format was undertaken in collaboration with students at Maynooth University as part of a novel crowdsourcing initiative to integrate data rescue activities into the classroom. In total, 3,616 station years of rainfall data (~1.32 million daily values) were transcribed. The data, which was double keyed, have undergone basic quality assurance to check for transcription errors and the resultant raw data and associated metadata are presented here. Ongoing work involves the application of further quality assurance and homogenization techniques to develop a long‐term, quality assured daily rainfall network for Ireland.
Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis
Authors: Unsinger Jacqueline , Walton Andrew H , Blood Teresa , Tenney Daniel J , Quigley Michael , Drewry Anne M , Hotchkiss Richard S 
Published: August 2020

Abstract
A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is characterized by profound apoptosis-induced depletion of CD4 and CD8 T cells and severely impaired T cell function. OX40, a member of the TNF receptor superfamily, is a positive co-stimulatory molecule expressed on activated T cells. When engaged by OX40 ligand, OX40 stimulates T cell proliferation and shifts the cellular immune phenotype toward TH1 with increased production of cytokines that are essential for control of invading pathogens. The purpose of the present study was to determine if administration of agonistic Ab to OX40 could reverse sepsis-induced immunosuppression, restore T cell function, and improve survival in a clinically relevant animal model of sepsis. The present study demonstrates that OX40 agonistic Ab reversed sepsis-induced impairment of T cell function, increased T cell IFN-γ production, increased the number of immune effector cells, and improved survival in the mouse cecal ligation and puncture model of sepsis. Importantly, OX40 agonistic Ab was not only effective in murine sepsis but also improved T effector cell function in PBMCs from patients with sepsis. The present results provide support for the use of immune adjuvants that target T cell depletion and T cell dysfunction in the therapy of sepsis-induced immunosuppression. In addition to the checkpoint inhibitors anti-PD-1 and anti-PD-L1, OX40 agonistic Ab may be a new therapeutic approach to the treatment of this highly lethal disorder.
Human Remains Identification, Grief, and Posttraumatic Stress in Bereaved Family Members 14 Years After the September 11, 2001, Terrorist Attacks
Authors: Cozza Stephen J. , Fisher Joscelyn E. , Hefner Kathryn R. , Fetchet Mary A. , Chen Shenglin , Zuleta Rafael F. , Fullerton Carol S. , Ursano Robert J. 
Published: August 2020

AbstractReturning human remains to family members after a loved one's death is thought to support grief adaptation. However, no known research has examined the effects that notifications of fragmented remains have on bereaved family members. We examined the number of notifications received, continuing questions about the death, grief severity, and posttraumatic stress (PTS) in family members bereaved by the September 11, 2001 attacks (N = 454). One notification was associated with fewer continuing questions compared to zero notifications, p = .037, or two or more notifications, p = .009. A model using notifications and continuing questions to predict grief severity showed there was no difference between receiving one and zero notifications, p = .244; however, receipt of two or more notifications was associated with higher grief severity compared to zero notifications, p = .032. A similar model demonstrated that receipt of any notifications was associated with PTS, ɳp2 = .026, p = .006. Having continuing questions was associated with grief severity, ɳp2 = .170, p < .001; and PTS, ɳp2 = .086, p < .001. Additionally, participants who received one notification and chose not to receive more had fewer continuing questions compared to all other participants, and participants who received two or more notifications and chose no future notifications had higher PTS levels compared to all other participants. The results indicate that human remains notification is not associated with reduced grief severity but is associated with PTS. These findings should inform notification policy and guide families’ notification choice after traumatic deaths.
Translanguaging as a Culturally Sustaining Pedagogical Approach: Bi/Multilingual Educators’ Perspectives
Authors: Tsokalidou Roula , Skourtou Eleni 
Published: August 2020

AbstractIn this paper we will focus on data from bi/multilingual educators and discuss aspects of translanguaging as a Culturally Sustaining Pedagogy (Paris and Alim, Culturally Sustaining Pedagogies. Teaching and Learning for Justice in a Changing World, Teachers College Press, New York, 2017). The data from the bi/multilingual educators come from a recent qualitative research (Tsokalidou, SiDaYes! Πέρα από τη διγλωσσία προς τη διαγλωσσικότητα/Beyond bilingualism to translanguaging, Gutenberg, Athens, 2017) that aimed to bring forward the issue of translanguaging (TL) in the everyday life of multi/bilinguals. Our findings suggest that TL could function as a means of increasing the confidence and self-esteem of minoritized students, while offering them a feeling of normality and pride for their linguistic and cultural backgrounds. It also becomes clear from our data that going against the grain of monolingualism and mono-culturalism is a great challenge for all.
$$\mathrm {L}^p$$-extrapolation of non-local operators: Maximal regularity of elliptic integrodifferential operators with measurable coefficients
Authors: Tolksdorf Patrick 
Published: August 2020

AbstractThe aim of this article is to deepen the understanding of the derivation of$$\mathrm {L}^p$$Lp-estimates of non-local operators. We review the$$\mathrm {L}^p$$Lp-extrapolation theorem of Shen (2005) which builds on a real variable argument of Caffarelli and Peral (1998) and adapt this theorem to account for non-local weak reverse Hölder estimates. These non-local weak reverse Hölder estimates appear, for example, in the investigation of non-local elliptic integrodifferential operators. This originates from the fact that here only a non-local Caccioppoli inequality is valid, see Kuusi, Mingione, and Sire (2015). As an application, we prove resolvent estimates and maximal regularity properties in$$\mathrm {L}^p$$Lp-spaces of non-local elliptic integrodifferential operators.
Erkenntnisse aus 10 Jahren CIRS‑AINS
Authors: Neuhaus C. , Holzschuh M. , Lichtenstern C. , St.Pierre M. 
Published: August 2020

Zusammenfassung
Hintergrund
„Critical-incident-reporting“-Systeme (CIRS) dienen dazu, Organisationen und Individuen für bislang unbekannte und sicherheitsrelevante Ereignisse zu sensibilisieren und dadurch Veränderungen herbeiführen zu können. In den letzten Jahren häufen sich allerdings kritische Stimmen, die Einsatz und Nutzen von CIRS in der Medizin hinterfragen, u. a. aufgrund unklarer bzw. zu allgemeiner inhaltlicher Kriterien für die Aufnahme einer Meldung in ein System. Ziel der Arbeit ist die Auswertung und Analyse aller Fälle aus CIRSmedical Anästhesiologie (CIRS-AINS) als Grundlage weiterer, differenzierter Betrachtungen.

Methode
In einer retrospektiven Datenbankanalyse wurden alle Fälle aus CIRS-AINS (April 2010–Juni 2019) inhaltlich analysiert.

Ergebnisse
Die gemeldeten 6013 Fälle setzen sich aus 3492 „incidents“ (58,1 %), 1734 „near-misses“ (28,8 %) und 787 sonstigen Meldungen (13,1 %) zusammen. Unter Letztere fielen 21 Konfliktmeldungen (0,4 %), 102 Beschwerden (1,7 %), 89 Überlastungsanzeigen (1,5 %) sowie 575 sonstige Meldungen, die keine CIRS-Fälle darstellen (9,6 %). Seit 2015 zeigt sich eine stetige Zunahme der sonstigen Meldungen um das 2,8-Fache von 7,4 % auf 20,8 %. In 20,1 % der Meldungen wurde Technik, in 27,7 % Medizinprodukte erwähnt. Medikamente waren in 10,7 % der Meldungen Gegenstand der Zwischenfälle. Aus dem perioperativen Umfeld wurden 47,8 % der stationären Zwischenfälle berichtet, 24,6 % aus den Bereichen Intensivstation/Aufwachraum. Das CIRS-Team des BDA analysierte und kommentierte 36,1 % der Fälle .

Schlussfolgerung
Die Analyse liefert Erkenntnisse für die Gestaltung zukünftiger Melderichtlinien und Anwenderschulungen. Insbesondere der Häufung „sonstiger“ Meldungen, welche nicht den Kriterien einer CIRS-Meldung entsprechen, sollte künftig Rechnung getragen werden.
Intra-hepatic Abscopal Effect Following Radioembolization of Hepatic Metastases
Authors: Powerski Maciej , Drewes Ralph , Omari Jazan , Relja Borna , Surov Alexey , Pech Maciej 
Published: August 2020

Abstract
Purpose
To search for abscopal effects (AE) distant to the site of radiation after sequential Yittrium-90 (Y-90) radioembolization (RE) of liver malignancies.

Methods and Materials
In this retrospective analysis, all patients treated by RE between 2007 and 2018 (n = 907) were screened for the following setting/conditions: sequential RE of left and right liver lobe in two sessions, liver-specific MRI (MRI1) acquired max. 10 days before or after first RE (RE1), liver-specific MRI (MRI2) acquired with a minimum time interval of 20 days after MRI1, but before second RE (RE2). No systemic tumor therapies between MRI1 and MRI2. No patients with liver cirrhosis. Metastases > 5 mm in untreated liver lobes were compared in MRI1 and MRI2 and rated as follows: same size or larger in MRI2 = no abscopal effect (NAE); > 30% shrinkage without Y-90 contamination in SPECT/CT = abscopal effect (AE).

Results
Ninety six of 907 patients met aforementioned criteria. Median time-frame between RE1 and MRI2 was 34 (20–64) days. These 96 cases had 765 metastases which were evaluable (median 5(1–40) metastases per patient). Four patients could be identified with at least one shrinking metastasis of the untreated site: one patient with breast cancer (3 metastases: 0 NAE; 3 AE), one patient with prostate cancer (6 metastases: 3 NAE; 3 metastases > 30% shrinkage but possible Y-90 contamination) and two patients with shrinkage of one metastasis each but less than 30%.

Conclusion
Our retrospective study documents AE after RE of liver tumors in 1 out of 96 cases, 3 other cases remain unclear.
Robust spotter scheduling in trailer yards
Authors: Tadumadze Giorgi , Boysen Nils , Emde Simon 
Published: August 2020

AbstractSpotters (also denoted as switchers) are specialized terminal tractors, which are dedicated to the rapid maneuvering of semitrailers between parking lot and dock doors in large trailer yards. This paper is dedicated to spotter scheduling, i.e., the assignment of predefined trailer movements to a given fleet of spotters. The limited number of dock doors for loading and unloading is often the scarce resource during trailer processing, so that idle time of the bottleneck, e.g., caused by unforeseen delay in the yard, is to be avoided. In this setting, we aim to insert time buffers between any pair of subsequent jobs assigned to the same spotter, so that small delays are not propagated and subsequent jobs can still be executed in a timely manner. We formalize two versions of the resulting robust spotter scheduling problem and provide efficient algorithms for finding optimal solutions in polynomial time. Furthermore, we simulate delays during the execution of spotter schedules and show that the right robustness objective can greatly improve yard performance.
Association of De Ritis ratio with oncological outcomes in patients with non-muscle invasive bladder cancer (NMIBC)
Authors: Laukhtina Ekaterina , Mostafaei Hadi , D’Andrea David , Pradere Benjamin , Quhal Fahad , Mori Keiichiro , Miura Noriyoshi , Schuettfort Victor M. , Sari Motlagh Reza , Aydh Abdulmajeed , Abufaraj Mohammad , Karakiewicz Pierre I. , Enikeev Dmitry , Kimura Shoji , Shariat Shahrokh F. 
Published: August 2020

Abstract
Purpose
The De Ritis ratio (aspartate aminotransferase/alanine aminotransferase, DRR) has been linked to oncological outcomes in several cancers. We aimed to assess the association of DRR with recurrence-free survival (RFS) and progression-free survival (PFS) in patients with non-muscle-invasive bladder cancer (NMIBC).

Methods
We conducted a retrospective analysis of 1117 patients diagnosed with NMIBC originating from an established multicenter database. To define the optimal pretreatment DRR cut‐off value, we determined a value of 1.2 as having a maximum Youden index value. The overall population was therefore divided into two De Ritis ratio groups using this cut‐off (lower, < 1.2 vs. higher, ≥ 1.2). Univariable and multivariable Cox regression analyses were used to investigate the association of DRR with RFS and PFS. The discrimination of the model was evaluated with the Harrel’s concordance index (C-index).

Results
Overall, 405 (36%) patients had a DRR ≥ 1.2. On univariable Cox regression analysis, DRR was significantly associated with RFS (HR: 1.23, 95% CI 1.02–1.47, p = 0.03), but not with PFS (HR: 0.96, 95% CI 0.65–1.44, p = 0.9). On multivariable Cox regression analysis, which adjusted for the effect of established clinicopathologic features, DRR ≥ 1.2 remained significantly associated with worse RFS (HR:1.21, 95% CI 1.00–1.46, p = 0.04). The addition of DRR only minimally improved the discrimination of a base model that included established clinicopathologic features (C-index = 0.683 vs. C-index = 0.681). On DCA the inclusion of DRR did not improve the net-benefit of the prognostic model.

Conclusion
Despite the statistically significant association of the DRR with RFS in patients with NMIBC, it does not seem to add any prognostic or clinical benefit beyond that of currently available clinical factors.
Depression profile in malignancy patients attending otorhinolaryngology clinic
Authors: Khadilkar Meera Niranjan , Pai K. Keshava , Rai Thripthi , Shenoy Vijendra , Dosemane Deviprasad , Kabekkodu Sushmitha 
Published: August 2020

Abstract
Purpose
Patients with malignancy quite often suffer from physical as well as psychological symptoms due to the shattering diagnosis, and prolonged, incapacitating management. The frequency of the depressive disorder in malignancy is around 8–40%. The present study aims at analysing the socio-demographic profile and magnitude of depressive disorders in patients with malignancy.

Methods
A cross-sectional study was conducted in malignancy patients attending an Ear Nose Throat department using the PHQ-9 questionnaire.

Results
Total PHQ-9 score ranged from 0 to 19; the mean score was 8.46. Major depressive disorder was seen in 4 (8%) cases, while other depressive disorder occurred in 22 (44%) cases. Mild severity of symptoms was noted in 15 (30%) of the patients. High statistical significance was noted between PHQ-9 score for MDD and other depressive disorder (p value < 0.001).

Conclusion
The profile of depressive disorders in malignancy varies; PHQ-9 can be used as a good tool for early detection.