bluuebunny/crossref_metadata_2025_split huggingface dataset:
What relationships do same‐sex parents foster with school in France? Analysis of parental strategies deployed to prevent any risk of homophobia
Authors: Richardot Sophie , Bureau Marie‐Christine 
Published: June 2020

AbstractWhat relationships do same‐sex parent families foster daily at school? Do they feel as welcome as any other family? Up until now, few studies exist on this subject, not only in France but internationally. The objective of this paper is therefore to rectify this lack through exploring the relationships that lesbian‐parented and gay‐parented families foster with educational establishments. Qualitative and quantitative data analysis of the DEVHOM study reveals that these parents deploy a certain number of strategies with the aim of preventing homophobia to which they or their child could fall victim. These strategies are based on: (1) a well‐considered choice of school; (2) controlled strategies of exposure; and (3) active participation in school life. Certain moments in school life are critical when it comes to dealing with parents and teaching staff (the election of parent representatives, administrative registration, “mother's day, father's day”). All the strategies put in place by same‐sex parents seem to prove effective as these parents feel little discrimination and consider that their children foster a positive relationship with their school.
Right atrial conduction time for predicting coexistent typical atrial flutter in patients with paroxysmal atrial fibrillation
Authors: Higuchi Satoshi , Ejima Koichiro , Shoda Morio , Kanai Miwa , Kataoka Shohei , Yazaki Kyoichiro , Yagishita Daigo , Yoshida Ayano , Tanino Sae , Saito Chihiro , Yagishita Yoshimi , Arai Kotaro , Ashihara Kyomi , Hagiwara Nobuhisa 
Published: June 2020

AbstractIntroductionScreening of coexistent typical atrial flutter (AFL) in patients with atrial fibrillation (AF) is sometimes challenging. This study investigated whether a prolonged right atrial conduction time (RACT) estimated by tissue Doppler imaging (TDI) predicts patients with concomitant AFL and AF.Methods and ResultsWe retrospectively analyzed 398 patients (mean age: 61.6 years, 73.4% men) undergoing catheter ablation of paroxysmal AF. The patients were classified into two groups according to whether they had evidence of AFL (N = 122, 30.7%) determined by a clinical observation (N = 68), induction during procedures (N = 33), or AFL recurrence after procedures (N = 21) or not (N = 276, 69.3%). The preoperative RACT, defined as a longer duration between the onset of the P‐wave and peak A′‐wave on the right atrial lateral wall or septal wall, and total atrial conduction time (TACT), defined as the same time duration on the left atrial lateral wall, were evaluated in all patients. Patients with evidence of AFL had a significantly longer RACT than those without AFL (p < .001). A multiple logistic regression and receiver operator characteristics curve analysis revealed the ratio of the RACT and TACT (RACT/TACT) was the independent and most superior accurate cofounder for predicting evidence of AFL (area under the curve: 0.867). When adding a discriminator of an RACT/TACT ≧ 93% into the conventional screening, 98.4% of the patients with evidence of AFL were estimated to be treated during the initial procedures.ConclusionThe estimated RACT/TACT using the TDI may be useful for predicting patients with concomitant AFL in patients with AF.
Recurrent ventricular tachycardia after cardiac sympathetic denervation: Prolonged cycle length with improved hemodynamic tolerance and ablation outcomes
Authors: Hayase Justin , Dusi Veronica , Do Duc , Ajijola Olujimi A. , Vaseghi Marmar , Lee Jay M. , Yanagawa Jane , Hoftman Nir , Revels Sha'Shonda , Buch Eric F. , Khakpour Houman , Fujimura Osamu , Krokhaleva Yuliya , Macias Carlos , Sorg Julie , Gima Jean , Pavez Geraldine , Boyle Noel G. , Shivkumar Kalyanam , Bradfield Jason S. 
Published: June 2020

AbstractIntroductionCardiac sympathetic denervation (CSD) is utilized for the management of ventricular tachycardia (VT) in structural heart disease when refractory to radiofrequency ablation (RFA) or when patient/VT characteristics are not conducive to RFA.MethodsWe studied consecutive patients who underwent CSD at our institution from 2009 to 2018 with VT requiring repeat RFA post‐CSD. Patient demographics, VT/procedural characteristics, and outcomes were assessed.ResultsNinety‐six patients had CSD, 16 patients underwent RFA for VT post‐CSD. There were 15 male and 1 female patients with mean age of 54.2 ± 13.2 years. Fourteen patients had nonischemic cardiomyopathy. A mean of 2.0 ± 0.8 RFAs for VT was unsuccessful before the patient undergoing CSD. The median time between CSD and RFA was 104 days (interquartile range [IQR] = 15–241). The clinical VT cycle length was significantly increased after CSD both spontaneously on ECG and/or ICD interrogation (355 ± 73 ms pre‐CSD vs. 422 ± 94 ms post‐CSD, p = .001) and intraprocedurally (406 ± 86 ms pre‐CSD vs. 457 ± 88 ms post‐CSD, p = .03). Two patients had polymorphic and 14 had monomorphic VT (MMVT) pre‐CSD, and all patients had MMVT post‐CSD. The proportion of mappable, hemodynamically stable VTs increased from 35% during pre‐CSD RFA to 58% during post‐CSD RFA (p = .038). At median follow‐up of 413 days (IQR = 43–1840) after RFA, eight patients had no further VT.ConclusionRFA for recurrent MMVT post‐CSD is a reasonable treatment option with intermediate‐term clinical success in 50% of patients. Clinical VT cycle length was significantly increased after CSD with associated improvement in mappable, hemodynamically tolerated VT during RFA.
MicroRNA‐183‐5p is stress‐inducible and protects neurons against cell death in amyotrophic lateral sclerosis
Authors: Li Chunyu , Chen Yongping , Chen Xueping , Wei Qianqian , Ou Ruwei , Gu Xiaojing , Cao Bei , Shang Huifang 
Published: June 2020

AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of motor neurons. A fundamental pathogenesis of ALS is the prolonged cell stress in neurons, which is caused by either accumulation of protein aggregates or reactive oxygen species. However, the mechanistic link between stress sensing and cell death is unsettled. Here, we identify that miR‐183‐5p, a neuron‐enriched miRNA, couples stress sensing and cell death programming in ALS. miR‐183‐5p is immediately induced by hydrogen peroxide, tunicamycin or TNF‐α in neurons. The overexpression of miR‐183‐5p increases neuron survival under stress conditions, whereas its knockdown causes neuron death. miR‐183‐5p coordinates apoptosis and necroptosis pathways by directly targeting PDCD4 and RIPK3, and thus protects neurons against cell death under stress conditions. The consistent reduction of miR‐183‐5p in ALS patients and mouse models enhances the notion that miR‐183‐5p is a central regulator of motor neuron survival under stress conditions. Our study supplements current understanding of the mechanistic link between cell stress and death/survival, and provides novel targets for clinical interventions of ALS.
Can Cross‐border Cooperation Boost Cross‐border Ethical Governance?*
Authors: Nadalutti Elisabetta 
Published: June 2020

AbstractIs there a ethical dimension in cross‐border cooperation? Although EU border scholars and practitioners highlight how important is to consider the normative dimension of cross‐border cooperation for its successful management, the ethical dimension has been instead so far neglected and understudied because of the lack of an appropriate methodological and theoretical background. Thus, I aim to fill this scholarly and policy‐making gap by addressing this main question and by proposing an alternative ethical‐humanist approach to cross‐border cooperation. It is argued that the cross‐border governance ethical code elaborated here is the necessary lynchpin to promote and strengthen integration and cohesion through cross‐border cooperation within the EU. The outcome of this analysis is an alternative modern cross‐border cooperation roadmap that promotes social conditions through which human beings as well as their natural environment can harmoniously develop through the fulfilment of specific ethical values.
The effects of fuel prices and vehicle sales on fuel‐saving technology adoption in passenger vehicles
Authors: Klier Thomas , Linn Joshua , Zhou Yichen C. 
Published: June 2020

AbstractAlthough economic theory suggests that both sales and fuel costs affect technology adoption by vehicle manufacturers, there is very little empirical evidence on either effect. We document a strong connection between a vehicle's sales and its energy efficiency. Using a demographics‐driven demand shifter to isolate demand‐side changes in sales, we find that a one standard deviation increase in sales raises efficiency by 0.2%, compared with a mean improvement rate of 1.4% per year between 1997 and 2013. Higher fuel prices also increase technology adoption directly by increasing willingness to pay for fuel cost savings. The results have two implications: manufacturers will continue to focus technological improvements on top selling vehicles; and fuel taxes will have larger effects on technology adoption than fuel economy standards and feebates.
Evidence for population genetic structure in two exploited Mekong River fishes across a natural riverine barrier
Authors: Biesack Ellen E. , Dang Binh T. , Ackiss Amanda S. , Bird Christopher E. , Chheng Phen , Phounvisouk Latsamy , Truong Oanh T. , Carpenter Kent E. 
Published: June 2020

AbstractImpacts of urban development on aquatic populations are often complex and difficult to ascertain, but population genetic analysis has allowed researchers to monitor and estimate gene flow in the context of existing and future hydroelectric projects. The Lower Mekong Basin is undergoing rapid hydroelectric development with around 50 completed and under‐construction dams and 95 planned dams. The authors investigated the baseline genetic diversity of two exploited migratory fishes, the mud carp Henicorhynchus lobatus (five locations), and the rat‐faced pangasiid catfish, Helicophagus leptorhynchus (two locations), in the Lower Mekong Basin using the genomic double digest restriction site‐associated DNA (ddRAD) sequencing method. In both species, fish sampled upstream of Khone Falls were differentiated from those collected at other sites, and Ne estimates at the site above the falls were lower than those at other sites. This was the first study to utilize thousands of RAD‐generated single nucleotide polymorphisms to indicate that the Mekong's Khone Falls are a potential barrier to gene flow for these two moderately migratory species. The recent completion of the Don Sahong dam across one of the only channels for migratory fishes through Khone Falls may further exacerbate signatures of isolation and continue to disrupt the migration patterns of regionally vital food fishes. In addition, H. lobatus populations downstream of Khone Falls, including the 3S Basin and Tonle Sap system, displayed robust connectivity. Potential obstruction of migration pathways between these river systems resulting from future dam construction may limit dispersal, which has led to elevated inbreeding rates and even local extirpation in other fragmented riverine species.
Pregnant Women with Obesity Have Unique Perceptions About Gestational Weight Gain, Exercise, and Support for Behavior Change
Authors: Faucher Mary Ann , Mirabito Ann M. 
Published: June 2020

IntroductionPrepregnancy obesity and excessive gestational weight gain (GWG) pose health risks to woman and fetus, yet gestational weight management interventions are largely unsuccessful. Little research examines the perceptions of women with obesity about weight gain and exercise. Although women with obesity have different body habitus and life experiences, most studies combine overweight and obese women into one group.MethodsWe conducted 3 focus groups with pregnant women with obesity to determine perceptions of GWG, exercise, and a proposed behavioral intervention.ResultsSeventeen women participated in the focus groups including 6 at a birth center and 11 at a federally qualified health center. A key finding was that women with obesity felt stigmatized and perceived pregnancy as a refuge from fat shaming. Participants viewed risks associated with excessive GWG as exaggerated and instead deemed self‐assessments of how they feel and look as more reliable measures of maternal and fetal health. Participants reported that quality rather than quantity of food promotes pregnancy health and that restrained eaters put their fetuses at risk. Knowledge gaps emerged related to dissatisfaction with counseling about weight gain guidelines. Although physical activity was endorsed, participants voiced safety concerns about exercise during pregnancy and instead favored walking and routine daily activity. Goal setting, positive messaging, and positive reinforcement were identified as favorable aspects of the proposed behavioral intervention.DiscussionPregnant women with obesity share other pregnant women's perceptions about weight gain and exercise in pregnancy but also have unique perceptions. Pregnant women with obesity in this study reported feeling stigmatized and fearful of being shamed by their health care providers but paradoxically eager for guidance. The findings offer implications for health care counseling and GWG interventions for this population.
Association of hemorrhage at termination in caesarean scar pregnancy using the crossover sign of ultrasound image
Authors: Wang Yan , Tan Guichun , Cheng Xianghong , Xu Yahui , Xu Fuxia , Qu Pengpeng 
Published: June 2020

AbstractPurposeTo analyze whether crossover sign (COS) can help predict the risk of bleeding during surgical evacuation in patients with caesarean scar pregnancy (CSP).MethodsThis study retrospectively analyzed the clinical presentations, ultrasound images and treatment outcomes of patients with CSP. The relationship among the gestational sac, caesarean scar and the anterior uterine wall, defined as the COS, was analyzed to predict the risk of severe bleeding during surgical evacuation in these patients. All patients were categorized according to the relationship between the endometrial line and the superior–inferior diameter of the gestational sac into crossover sign‐1 and crossover sign‐2 groups. The Mann–Whitney U test was used to compare the data with non‐normal distribution, and logistic regression analysis was performed to identify the correlates of severe bleeding.ResultsA total of 74 patients were included. In COS‐1 group (n = 21), 16 (76.19%) patients suffered heavy bleeding(≥200 mL) during surgical evacuation, while COS‐2 group (n = 53) had only 1(11.89%) patient complaint of heavy bleeding (≥200 mL) (P < 0.01). Adverse surgical outcomes were more common in women with COS‐1. Logistic regression analysis showed that COS‐1 (OR, 7.93; 95% CI, 1.35–46.67) was independently associated with severe bleeding.ConclusionCOS can help predict who has a higher risk of severe hemorrhage in patients with CSP and guide the clinical treatment selection for optimal management of this condition.
The Millennial ‘Meh’: Correlated Groups as Collective Agents in the Automobile Field
Authors: Montgomery A. Wren , Wolske Kimberly S. , Lyon Thomas P. 
Published: June 2020

AbstractExplanations for field change emphasize the role of purposeful strategic actors, paying little attention to uncoordinated but cohesive social groups, despite their profound impacts on fields ranging from autos and news to politics. Using a mixed methods approach, we study Millennials’ driving behaviours, focusing on the role of generation cohorts as field actors. Combining in‐depth qualitative analysis with an original nationwide survey (N = 2,225) we find that Millennials exhibit significantly different driving behaviour than earlier generations, driving for roughly 8 per cent fewer trips. These differences are primarily due to their attitudes, not, as commonly presumed, socio‐economic factors. Our results contribute to theory on fields and collective actors. First, we identify a new field phenomenon, correlated groups, uncoordinated actors behaving as collective agents due to shared experiences and characteristics. Second, we identify four mechanisms through which correlated groups impact fields: correlated imprinting, cohorts as conduit, cohort myth apathy, and cohort myth creation.
Ambulatory electrocardiography and serum cardiac troponin I measurement in 21 dogs envenomated by the European adder (Vipera berus)
Authors: Harjen Hannah J. , Bjelland Annelin A. , Harris Joanne , Grøn Tone K. , Anfinsen Kristin P. , Moldal Elena R. , Rørtveit Runa 
Published: June 2020

AbstractBackgroundEnvenomation by the European adder (Vipera berus) is common in dogs in Europe. Cardiac arrhythmias occur but clinical studies of envenomated dogs are limited.ObjectivesTo describe arrhythmias in dogs within 48 hours of envenomation, and investigate associations between arrhythmia grade, serum troponin I (cTnI), and snakebite severity score (SS score).AnimalsTwenty‐one client‐owned dogs bitten byV berus.MethodsProspective cohort study of envenomated dogs. Ambulatory electrocardiograms were recorded from presentation to 48 hours after snakebite, and arrhythmias graded 0 to 3 based on frequency and severity. Serum cTnI was measured at presentation, 12 hours, 24 hours, 36 hours, and 14 days after bite. An SS score of 1 to 3 was recorded at admission and based on clinical examination.ResultsAll dogs survived. Twelve dogs (57%) developed arrhythmias, all of which were ventricular in origin. Severe complex ventricular arrhythmias (VAs) were observed in 6 dogs (29%). Eighty‐one percent of dogs (n = 17) had increased cTnI concentrations at 1 or more time points. Dogs that developed arrhythmias had significantly higher concentrations of cTnI at 12 hours (1.67 [0.04‐32.68] versus 0.03 [0.01‐0.052];P= .002), 24 hours (1.88 [0.2‐14.23] versus 0.06 [0.01‐2.06];P= .009), and 36 hours (3.7 [0.02‐16.62] versus 0.06 [0.01‐1.33];P= .006) after bite compared to those that did not. Contingency table analysis showed that SS score was not significantly associated with arrhythmia grade (P= .9).Conclusions and Clinical ImportanceMyocardial cell injury, reflected by increased cTnI concentrations and VAs, is common afterV berusenvenomation in dogs. Prolonged electrocardiography monitoring is advised, particularly where cTnI is increased.
Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats
Authors: Brosnan Robert J. , Pypendop Bruno H. , Stanley Scott D. 
Published: June 2020

AbstractDifferent structurally related phenylpiperidine opioids exhibit different isoflurane‐sparing effects in cats. Because minimum alveolar concentration (MAC) in cats is affected only by very high plasma concentrations of some phenylpiperidine opioids, we hypothesized these effects are caused by actions on nonopioid receptors. Using a prospective, randomized, crossover design, six cats were anesthetized with isoflurane, intubated, ventilated, and instrumented. Isoflurane MAC was measured in triplicate using a tail‐clamp and bracketing technique. A computer‐controlled intravenous infusion using prior pharmacokinetic models targeted plasma concentrations of 60 ng/ml fentanyl, 10 ng/ml sufentanil, or 500 ng/ml alfentanil, and isoflurane MAC was measured in duplicate. Next, naltrexone 0.6 mg/kg was administered to cats hourly during the opioid infusion, and isoflurane MAC was measured in duplicate. Blood was collected during MAC determinations to measure opioid concentrations. Responses were analyzed using repeated measures ANOVA with significance atp < .05. Alfentanil and sufentanil decreased isoflurane MAC by 16.4% and 6.4%, respectively, and these effects were completely reversed by naltrexone. Fentanyl had no significant effect on isoflurane MAC. Alfentanil and sufentanil modestly reduce isoflurane MAC via agonist effects on opioid receptors. However, these effects are too small to justify clinical use of phenylpiperidine opioids as single agents to reduce MAC in cats.
Towards Greater Collaboration in Educational Neuroscience: Perspectives From the 2018Earli‐SIG22Conference
Authors: van Atteveldt Nienke , Peters Sabine , De Smedt Bert , Dumontheil Iroise 
Published: June 2020

ABSTRACTThe special issue resulting from the 2018 Earli‐SIG22 conference reflects the current state of the field, the diversity of methods, the persevering limitations and promising directions towards solutions. About half of the empirical papers in this special issue that consist of three parts, uses behavioral, self‐report or qualitative measures to understand the “mind” level ofMind, Brain, and Education. The other half investigates the “brain” level, using neuroimaging but also genetics or eye‐tracking to gain access to the wider range of biological substrates of learning and cognition. These biological studies mostly have added value by refining psychological theories, such that these inspire new hypotheses to test in the field, to ultimately better inform teaching. Importantly, the special issue presents several approaches to more intensive, bi‐directional and systematic practice‐research collaborations to better connect the “mind” and “brain” levels to education, and to equip researchers to realize such collaborations successfully in the future.
Ecological divergence in sympatry causes gene misexpression in hybrids
Authors: McGirr Joseph A. , Martin Christopher H. 
Published: June 2020

AbstractEcological speciation occurs when reproductive isolation evolves as a byproduct of adaptive divergence between populations. Selection favouring gene regulatory divergence between species could result in transgressive levels of gene expression in F1 hybrids that may lower hybrid fitness. We combined 58 resequenced genomes with 124 transcriptomes to identify patterns of hybrid gene misexpression that may be driven by adaptive regulatory divergence within a young radiation ofCyprinodonpupfishes, which consists of a dietary generalist and two trophic specialists—a molluscivore and a scale‐eater. We found more differential gene expression between closely related sympatric specialists than between allopatric generalist populations separated by 1,000 km. Intriguingly, 9.6% of genes that were differentially expressed between sympatric species were also misexpressed in F1 hybrids. A subset of these genes were in highly differentiated genomic regions and enriched for functions important for trophic specialization, including head, muscle and brain development. These regions also included genes that showed evidence of hard selective sweeps and were significantly associated with oral jaw length—the most rapidly diversifying skeletal trait in this radiation. Our results indicate that divergent ecological selection in sympatry can contribute to hybrid gene misexpression which may act as a reproductive barrier between nascent species.