bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudo compact almost automorphic solutions to a family of delay differential equations
Authors: Zheng Feng-Xia , Li Hong-Xu 
Published: December 2024

Abstract
In this article, a family of delay differential equations with pseudo compact almost automorphic coefficients is considered. By introducing a concept of Bi-pseudo compact almost automorphic functions and establishing the properties of these functions, and using Halanay’s inequality and Banach fixed point theorem, some results on the existence, uniqueness and global exponential stability of pseudo compact automorphic solutions of the equations are obtained. Our results extend some recent works. Moreover, an example is given to illustrate the validity of our results.
Harbingers of sepsis misdiagnosis among pediatric emergency department patients
Authors: Sawicki Jonathan G. , Graham Jessica , Larsen Gitte , Workman Jennifer K. 
Published: December 2024

Abstract

Objectives
To identify clinical presentations that acted as harbingers for future sepsis hospitalizations in pediatric patients evaluated in the emergency department (ED) using the Symptom Disease Pair Analysis of Diagnostic Error (SPADE) methodology.

Methods
We identified patients in the Pediatric Health Information Systems (PHIS) database admitted for sepsis between January 1, 2004 and December 31, 2023 and limited the study cohort to those patients who had an ED treat-and-release visit in the 30 days prior to admission. Using the look-back approach of the SPADE methodology, we identified the most common clinical presentations at the initial ED visit and used an observed to expected (O:E) analysis to determine which presentations were overrepresented. We then employed a graphical, temporal analysis with a comparison group to identify which overrepresented presentations most likely represented harbingers for future sepsis hospitalization.

Results
We identified 184,157 inpatient admissions for sepsis, of which 15,331 hospitalizations (8.3 %) were preceded by a treat-and-release ED visit in the prior 30 days. Based on the O:E and temporal analyses, the presentations of fever and dehydration were both overrepresented in the study cohort and temporally clustered close to sepsis hospitalization. ED treat-and-release visits for fever or dehydration preceded 1.2 % of all sepsis admissions.

Conclusions
In pediatric patients presenting to the ED, fever and dehydration may represent harbingers for future sepsis hospitalization. The SPADE methodology could be applied to the PHIS database to develop diagnostic performance measures across a wide range of pediatric hospitals.
Three-way comparison of different ESR measurement methods and analytical performance assessment of TEST1 automated ESR analyzer
Authors: Chaiwong Kwanlada , Naksith Rujira , Laiklang Waroonkarn , Yeekaday Manissara , Wongkamchai Suppakorn , Limpornpukdee Orakan , Ketloy Chutitorn , Prompetchara Eakachai 
Published: December 2024

Abstract

Objectives
Validation and performance assessment of novel ESR analyzer is required before implementation. The objective of this study was to assess the correlation between three ESR measurement methods. Full validation and performance assessment of an alternate method (TEST1) were also evaluated.

Methods
Three-way correlation assessment for the Westergren (WG), modified Westregren (Mixrate), and alternate (TEST1) methods were performed. Analytical performance of TEST1 including precision, carryover, sample stability, potential interferences as well as effect of hematocrit (Hct) and mean corpuscular volume (MCV) were also determined.

Results
Strong correlation between three ESR measurement methods were observed. Correlation coefficient (r) was 0.902, 0.977, and 0.949 for WG vs. TEST1, WG vs. Mixrate, and TEST1 vs. Mixrate, respectively with absolute bias <5 mm. For TEST1, precision and carryover were within the manufacturer’s claim. Samples were stable upto 24 h and 48 h when they were stored at room temperature or 2–8 °C, respectively. No effect of trigyceride and cholesterol was observed. In low Hct samples, no significant different between the results obtained from Fabry’s formula corrected WG values and from TEST1.

Conclusions
Three-way comparison study yielded a strong correlation between methods. As part of the method validation before implementing a new analyzer, full validation of TEST1 showed that all validated parameters met the manufacturer’s specifications. A negative bias was observed but remains within the acceptable criteria. Difference in values for samples with low hematocrit were noted, but these can be corrected by Fabry’s formula applied to the values from WG method.
Iron in ventricular remodeling and aneurysms post-myocardial infarction
Authors: Wang Zuoyan , Ding Xiang , Pan Jingyu , Wang Xueyan , Lin Jieming , Wang Xinzhu 
Published: December 2024

Abstract

Background
Post-myocardial infarction (MI) complications, including ventricular remodeling (VR) and left ventricular aneurysm (LVA) formation, significantly affect patient prognosis and quality of life. Both iron overload and deficiency play critical roles in these pathological processes.

Objectives
This review aims to explore the mechanisms linking abnormal iron metabolism with post-MI VR and LVA formation and to highlight therapeutic strategies that regulate iron levels to mitigate adverse cardiac remodeling.

Methods
The review analyzes existing clinical and experimental research on the role of iron metabolism in post-MI complications. It focuses on iron overload, oxidative stress, ferroptosis, and the impact of iron deficiency on mitochondrial function, energy metabolism, and cardiomyocyte repair.

Results
Iron overload exacerbates myocardial injury through oxidative stress, ferroptosis, and inflammation, leading to fibrosis and ventricular dilation. In contrast, iron-deficiency impairs mitochondrial function, energy metabolism, and cardiomyocyte repair, further contributing to adverse remodeling outcomes. Therapeutic strategies such as iron chelators, ferroptosis inhibitors, and iron supplementation are potential interventions for mitigating adverse remodeling.

Conclusion
Abnormal iron metabolism, both overload and deficiency, plays a critical role in post-MI complications. Therapeutic strategies targeting iron levels hold promise for reducing adverse cardiac remodeling and improving patient outcomes after MI.
PEG-PLGA core–shell nanoparticles for the controlled delivery of picoplatin–hydroxypropyl β-cyclodextrin inclusion complex in triple-negative breast cancer: In vitro and in vivo study
Authors: Nafie Mohamed S. , Sedky Nada K. , Hassan Hatem A. F. M. , Fawzy Iten M. , Abdelhady Manal M. M. , Bakowsky Udo , Fahmy Sherif Ashraf 
Published: December 2024

Abstract
In this study, we prepared an inclusion complex of picoplatin (Pc) with 2-hydroxy propyl β cyclodextrin (HPCD) to improve its hydrophilicity, yielding Pc-HPCD. The Pc-HPCD complex was encapsulated into PEG-PLGA nanoparticles (NPs) using the emulsion–solvent evaporation method, yielding Pc-HPCD@PEG-PLGA core–shell NPs. The inclusion complex was assessed using 1HNMR spectroscopy and a phase solubility study. In addition, the average hydrodynamic diameter, polydispersity index, zeta potential, and encapsulation efficiency (EE%) of the Pc-HPCD@PEG-PLGA NPs were 190.2 ± 8.7 nm, 0.14 ± 0.02, −13.97 ± 0.67 mV, and 80.7 ± 2.4%, respectively. In vitro release study showed a pH-triggered release manner. Furthermore, the biological evaluation of Pc-HPCD@PEG-PLGA NPs revealed a significantly potent cytotoxic activity (IC50 = 1.6 ± 0.24 µg/ml) against triple-negative breast cancer cells (TNBC), surpassing that of Pc-HPCD (IC50 = 5.3 ± 0.93 µg/ml) and Pc (IC50 = 7.5 ± 0.4 µg/ml). Pc-HPCD@PEG-PLGA NPs induced significant apoptosis and the ability to arrest cells at the sub-G1 phase in MDA-MB-231 cells. Moreover, in an in vivo model established using SEC-bearing mice, treatment with Pc-HPCD@PEG-PLGA demonstrated significant inhibition of tumor proliferation (67.2%). This was accompanied by improvements in hematological and biochemical measurements, as well as histopathological examination, which indicated a reduction in cellular and nuclear pleomorphism. Our study demonstrated the potential of Pc-HPCD@PEG-PLGA NPs to be employed as an effective and safe therapy capable of conquering TNBC.
Empreendimentos solidários no território: experiências para o fortalecimento e expansão nas regiões Norte / Noroeste Fluminense e Vale do Itabapoana
Authors: Bastos Paula Aparecida Martins Borges , Fernandes Rogério Ribeiro , Souza Sandra Márcia Gonçalves de 
Published: December 2024

O presente trabalho pretende abordar experiências desenvolvidas pela ITCP/IFFluminense com apoio da Chamada Pública CNPq/MTb-SENAES Nº 27/2017, tendo como objetivo fortalecer e expandir a economia solidária nos territórios Norte/Noroeste Fluminense e Vale do Itabapoana. As bases metodológicas norteadoras utilizadas para o desenvolvimento das atividades foram a pesquisa-ação e a educação popular. A ITCP/IFFluminense atuou principalmente com grupos envolvidos na produção de alimentos artesanais, gastronomia local e agricultura familiar. Diversas atividades de capacitação foram realizadas, dentre elas: visitas técnicas, oficinas e cursos. A expansão da economia solidária nessas regiões se deu a partir de eventos como o “Seminário de Economia Solidária e Agricultura Familiar” realizado em Bom Jesus e também do apoio à participação dos grupos em eventos e feiras. Questões identitárias, conflitos interpessoais entre os membros dos empreendimentos e formas de relação entre incubadora e grupo incubado foram percebidos como focos sensíveis a serem tratados com atenção para superação e avanço nos processos de incubação e também dos empreendimentos.Palavras-chave: economia solidária; produção artesanal de alimentos; mulheres; empreendimento feminino. Abstract: The present work intends to approach experiences developed by ITCP / IFFluminense with support from the Public Call CNPq / MTb-SENAES Nº 27/2017, aiming to strengthen and expand the solidarity economy in the North / Northwest Fluminense and Vale do Itabapoana territories. The guiding methodological bases used for the development of activities were action research and popular education. ITCP / IFF worked mainly with groups involved in the production of artisanal food, local cuisine and family farming. Several training activities were carried out, including: technical visits, workshops and courses. The expansion of the solidarity economy in these regions was based on events such as the “Solidarity Economy and Family Agriculture Seminar” held in Bom Jesus and also by supporting the participation of groups in events and fairs. Identity issues, interpersonal conflicts between members of the ventures and forms of relationship between the incubator and the incubated group were perceived as sensitive focuses to be treated with attention in order to overcome and advance in the incubation processes and also in the ventures.Keywords: solidarity economy; artisan food production; women; female enterprise.
“I am air and fire...”: On the Interpretation of Anna Akhmatova’s Poem Cleopatra
Authors: Mikhailova Galina 
Published: December 2024

In interpreting Akhmatova’s poem Cleopatra, attention is often primarily given to its historical and social parameters, which are involved in the poem’s meaning-making process. This article suggests focusing on the literary sources of the poem (Shakespeare’s tragedy Antony and Cleopatra and Horace’s ode), exploring Akhmatova’s working notes, different versions of the lyrical heroine in her poetry, as well as the reproduction of her image in poems dedicated to her, testimonies of memoirists, essays, and philological observations of Akhmatova’s contemporaries. In this case, the poem may be read within the framework of the poet’s intimate relationship with ‘being’, and it may turn out to be a space for the embodiment of the author’s essential personal characteristics.
Variations on the Themes of Netochka Nezvanova
Authors: Beržaitė Dagnė 
Published: December 2024

The author of the article examines Fyodor Dostoevsky’s first multi-plot novel Netochka Nezvanova while also exploring the versions and reasons for the novel’s incompletion. The article suggests reading it in the context of the autobiographical works of Anna Grigorievna Dostoevskaya. The article draws a parallel between the first part of the novel about the musician Efimov and fragments from the Diaries and Memoirs of the writer’s wife. For the contemporary reader, accustomed to reading differently constructed texts, these fragments might be perceived as a kind of sequel to the early unfinished work (for example, the names of the novel’s heroine and the writer’s second wife, certain dates, behavioral models, and similar situations). The article suggests the idea that incorporating a literary text into the context of a writer’s biography is one way of ‘completing the incomplete’, while at the same time expanding the possibilities of interpreting classic works.
Time Spent on Homework: Correlations Between Parents’ and Teachers’ Perceptions and Children’s Performance
Authors: Šilinskas Gintautas , Raižienė Saulė 
Published: December 2024

This study investigated differences in teachers’ and parents’ perceptions about homework and their correlations with children’s achievement in Grade 4 – the end grade for primary school in Lithuania. Data were collected at the end of Grade 4 (February–March 2024). Teachers (n = 39) answered online questionnaires on homework frequency and expected homework time; parents (n = 525) completed paper questionnaires about homework frequency, time, and help. Children (n = 576) completed tests measuring literacy and math skills, and school administrations provided children’s Grade 4 grades and results from national standardized testing. Most parents and teachers reported that homework was assigned daily. Teachers reported that children should spend around one hour daily on homework; parents reported children spending on average one hour and ten minutes daily on homework and a great variation in the amount of weekly homework help children received. Compared to teachers, parents reported more frequent homework and more homework time. Only parental reports of time spent and help received for homework significantly correlated to children’s academic performance measures, albeit negatively. Overall, parents and teachers perceived homework time differently. Additionally, the less well Grade 4 students did academically, the more time they spent on homework, and the more help they required from family.
Examining the sustainability of current account deficits using a probability approach
Authors: Ndzama Nwabisa Florence 
Published: December 2024

AbstractWe propose a novel probability approach to examine the sustainability of the current account balance by generating density forecasts and calculating the probability that the current account balance will be lower than a specified threshold. We define a current account as sustainable by having a low probability of the current account deficit exploding. We use a vector autoregressive model to generate density forecasts up to five years ahead. We apply the method to ten countries that had high current account deficits in the past and find cases with both high and low probability of sustainability. We analyse historical episodes to illustrate the predictive capability of our framework and find that our method would have worked well in the past. We further find that the sustainability risk does not relate to whether the government or the private sector is the main driver of the deficit.
Embracing a network approach in digital transformation: Is it possible to change the strategic paradigm in Bulgaria?
Authors: Bogdanova Margarita , Parashkevova-Velikova Evelina 
Published: December 2024

AbstractThe purpose of the article is to assess the extent to which digital transformation policies in Bulgaria are modernized and receptive to new multi-sectoral reform approaches. Criteria were developed to evaluate the alignment of government documents with one or more strategic paradigms. An analysis was conducted on eight strategic documents related to digital transformation in Bulgaria, developed after 2010. This analysis utilized the Grounded Theory Coding procedure for inductive category development and applied codes from the criteria framework. Atlas.ti software was used for textual analysis, which provided quantitative data on the frequency of codes meeting the defined criteria for each strategic paradigm. The initial document evaluation was complemented by a qualitative content analysis to clarify the criterion-based findings and further explore the influence of different paradigms. In-depth interviews with representatives from public sector organizations confirmed and enriched some of the conclusions drawn during the analysis. The study finds that (1) the traditional approach dominated the early strategic documents but was gradually displaced by New Public Management; and (2) the network approach is insufficiently represented in the vision and strategic goals of Bulgaria's digital transformation process.
Tom Standage: <i>An Edible History of Humanity</i> & Cormac Ó Gráda: <i>Famine: A Short History</i> & Janet Clarkson: <i>Pie</i> & Bruce Kraig: <i>Hot Dog</i> & Fred Czarra: <i>Spices</i>
Authors: Jaine Tom 
Published: December 2024

Tom Standage: An Edible History of Humanity (Atlantic Books; 288 pp. £19.99)
Cormac Ó Gráda: Famine: A Short History (Princeton University Press; 344 pp. £16.95)
Janet Clarkson: Pie (Reaktion Books; 128 pp. £8.99)
Bruce Kraig: Hot Dog (Reaktion Books; 128 pp. £8.99)
Fred Czarra: Spices (Reaktion Books; 128 pp. £8.99)
Nigel Garwood & Rainer Voigt, with a preface by Anton Mosimann: Food Mania
Authors: Jaine Tom 
Published: December 2024

Nigel Garwood & Rainer Voigt, with a preface by Anton Mosimann: Food Mania: Thames & Hudson, London, 2001: ISBN 0-500-28296-X: 400 pp., 482 illus., colour and monochrome, p/b, £16.95.
Cid Reyes (ed): Kusina, What's Cooking in the Philippines & Virginia Races de Guzman & Nina Daza Puyat: The Philippine Cookbook
Authors: Davidson Alan E 
Published: December 2024

Cid Reyes (ed): Kusina, What's Cooking in the Philippines: Larawan Books, Manila, 1991: 256 pp, numerous colour and b/w illustrations, no index (but full table of contents is helpful), price not stated (and there are signs in our copy that Philippine Airlines may be giving copies away).
Virginia Races de Guzman & Nina Daza Puyat: The Philippine Cookbook: Bookmark, Manila, 1990: about 130 pages including blank forms for additional recipes, decorative b/w drawings by Louie Magbanua, large 3-ring binder with room for further sheets, price not stated.
Efficacy of IsaPomDex triplet therapy in double refractory multiple myeloma patients in real clinical practice in Russia
Authors: Solovev M. V. , Solovevа M. V. , Mendeleeva L. P. , Pospelova T. I. , Skvortsova N. V. , Garifullin A. D. , Chuprakova A. S. , Mitina T. A. , Usankin I. S. , Vasileva I. V. , Medvedeva N. V. , Ryabchikova V. V. , Kiseleva M. Ya. , Dudina G. A. , Gammershmidt Yu. S. , Kuznetsova O. S. , Dolgushina Yu. V. , Kuchma G. B. , Tsyganok T. N. , Misyurina E. N. , Zhelnova E. I. , Kopylova A. V. , Zakharova M. N. , Korobkin A. V. , Tumyan G. S. , Semenova A. A. , Kirillova E. G. , Volodicheva E. M. , Bakhtina V. I. , Olkhovik T. I. , Solovkova N. R. , Demchenkova M. V. , Ochirova O. E. , Panteleeva O. L. , Abramova V. S. 
Published: December 2024

Background. Data from real-life clinical practice studies provide additional information on the efficacy of new antitumor therapy regimens, including in patients who meet exclusion criteria for clinical trials.Aim. To evaluate the Isaomex triplet efficacy in multiple myeloma patients in real clinical practice.Materials and methods. From 2021 to 2024, the retrospective study included 83 double refractory multiple myeloma patients from 26 centers aged 38 to 85 years (median 63), who received the Isaomex triplet. Glomerular filtration rate ˂ 60 mL/min was detected at the time of isatuximabbased triplet initiation in 18 % patients, 2 of whom were on program hemodialysis. The median of previous therapy lines was 2 (1–6). The median time from diagnosis to initiation of isatuximabbased triplet therapy was 47 months (5–203). Survival curves were constructed using the Kaplan–Meier method. Statistical analysis was performed using Statistica 10 program.Results. Isaomex triplet therapy resulted in overall and renal responses in 76 % and 61 % of cases, respectively. The median progression free survival was 13.5 months. In the group of patients who did not receive daratumumab at previous stages, the median progression free survival was significantly higher and was 28 months vs 8 months (p ˂ 0.05). Threeyear overall survival was 81 %. Discontinuation of isatuximab due to the development of adverse event was recorded in 2 cases (2 %). In the group of patients with bone plasmacytomas (n = 46), Isaomex therapy resulted in an overall response rate of 67 %; 12‑month progression free survival was 48 %, and 1‑year overall survival was 76 %.Conclusion. The results of the Isaomex triplet use in real clinical practice for the treatment of relapsed multiple myeloma showed data comparable to the ICARIA registration study on the frequency of achieving a response, duration of progression free survival and overall survival. The triplet efficiency was shown in comorbid patients, with advanced stages and those undergoing renal replacement therapy.
IL4 and TLR3 gene polymorphism in infectious complications in patients with acute myeloid leukemia
Authors: Korobov S. O. , Nazarova E. L. , Dokshina I. A. 
Published: December 2024

Background. Patients with acute myeloid leukemia (AML) are predisposed to infectious complications (IC). Single nucleotide polymorphisms in genes can affect the function and/or expression of the proteins they encode. Since the functioning of the innate immune system is under genetic control, identifying polymorphic variants that reduce the effectiveness of the immune response is a promising method for identifying patients at high risk of severe infections.Aim. To evaluate the relationship between presence of single nucleotide polymorphisms TLR3 C1234G and IL4 C589T with IC frequency in AML patients.Materials and methods. TLR3 C1234G and IL4 C589T polymorphisms were genotyped in 93 patients with AML, of which 77 (82.80 %) – de novo AML, 16 (17.20 %) – AML with previous myelodysplastic syndrome. Patients received 263 chemotherapy courses. Median age was 58 (Q1–Q3: 38–66) years, 50 (53.76 %) were men, 43 (46.24 %) were women. Sepsis and pneumonia were considered severe IC. Allele-specific polymerase chain reaction with detection of amplification products in a 3 % agarose gel was used to genotype single nucleotide polymorphisms in immune response genes.Results. Severe IC were developed in 57 (21.67 %) chemotherapy courses. It was found that in patients with the TLR3 1234GG genotype, compared with carriers of the TLR31234CC genotype, the frequency of severe IC is 4.8 times lower (odds ratio 0.21; p = 0.022). Severe IC occurred 2.3 times more often in heterozygous carriers of the IL4 C589T polymorphism than in homozygous carriers of the C allele (odds ratio 2.29; p = 0.025). In multivariate analysis, taking into account age, gender and severity of neutropenia, the TLR31234GG and IL4 589CT genotypes variants remained independent predictors of IC.Conclusion. The TLR3 1234CC and IL4589CT genotypes are associated with the risk of severe IC in AML patients.