bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotional intelligence and knowledge management: A necessary link?
Authors: Rechberg Isabel D. W. 
Published: December 2019

AbstractThis theoretical paper studies the effect of emotional intelligence (EI) on individuals' participation in knowledge management (KM) practices. Individuals are the sources of knowledge, and EI may advance individuals' self‐awareness, self‐management, social awareness, and relationship‐management skills, which in turn positively impacts their knowledge processing behavior. The argument is made that knowledge creation is enabled through individuals' ability to recognize and correctly interpret emotional and environmental clues. Knowledge sharing is facilitated through individuals' interpersonal, communication, and team‐working skills, enabled through self‐awareness and social awareness. Knowledge is retained in organizations where EI enacts individuals' corporate citizenship behavior, adaptability, and job satisfaction. Where knowledge is power, knowledge management as a discipline may face difficulties, as the attempt to manage knowledge can result in individuals' resistance. Suggestions are provided on how organizations can adapt operations to meet the needs of the knowledge carriers, integrating EI into its strategic plan. Implications for the industry and further research suggestions are followed by conclusions.
Scale effects of sediment retention, water yield, and net primary production: A case‐study of the Chinese Loess Plateau
Authors: Su Changhong , Dong Min , Fu Bojie , Liu Guohua 
Published: December 2019

AbstractEcosystem services are generated by ecological processes over a range of scales. Studying the scale effects on ecosystem services is important for exploring the driving mechanisms and conducive to prudent ecological managements. Unfortunately, quantitative testing the scale effects of ecosystem services' associations, as well as identifying the driving mechanisms across scales, has rarely been documented. This study used the Loess Plateau as study area to test the scale effects and the correlations between sediment retention, water yield, and net primary production (NPP) and their driving mechanisms. A model of Integrated valuation of Ecosystem Services and Tradeoff 3.0 and the Carnegie‐Ames‐Stanford Approach were used to assess the services of sediment retention, water yield, and NPP in 2000 and 2008. Canonical correlation analysis (CCA) was used to quantify the driving mechanisms of ecosystem services. The results indicated that the ecosystem services are more varied in spatial patterns at small scale than at large scale. The average values of sediment retention, water yield, and NPP at small scale increased during the period. However, at large scale, the average values of sediment retention and water yield decreased and the NPP value increased simultaneously. Generally, the correlations between ecosystem services weakened when the spatial scale increased. The results from CCA indicated that, at small scale, the natural factors of precipitation, hours of sunshine, and temperature were the principal driving factors underlying ecosystem services. When the scale increased, the socioeconomic factors of population, grain production, and nonfarming production were gradually integrated into the factors driving the patterns of ecosystem services.
Microbiome of the deep Lake Baikal, a unique oxic bathypelagic habitat
Authors: Cabello‐Yeves Pedro J. , Zemskaya Tamara I. , Zakharenko Alexandra S. , Sakirko Mariya V. , Ivanov Vyacheslav G. , Ghai Rohit , Rodriguez‐Valera Francisco 
Published: December 2019

AbstractLake Baikal is the deepest lake in the world. Its depth provides the only bathypelagic (> 1000 m deep) freshwater habitat on Earth and its oxic, ultra‐oligotrophic features make it a freshwater counterpart of the deep ocean. Here we have analyzed metagenomes from 1250 and 1350 m deep samples and built 231 metagenome‐assembled genomes (MAGs). We detected high fractions of Thaumarchaeota (ca. 20% of 16S rRNA reads) and members of the candidate phyla radiation (CPR) (3–4.5%). Among the MAGs, we obtained ammonia‐oxidizing archaea (AOA, Nitrosopumilaceae) and bacteria (AOB, Nitrosomonadaceae), and nitrite‐oxidizers (Nitrospirae) indicating very active nitrification. A new clade of freshwater SAR202 Chloroflexi and methanotrophs (Methyloglobulus) were also remarkably abundant, the latter reflecting a possible role of methane oxidation as well. Novel species of streamlined and cosmopolitan bacteria such as Ca. Fonsibacter or acI Actinobacteria were more abundant at the surface but also present in deep waters. Conversely, CPRs, Myxococcales, Chloroflexi, DPANN (Diapherotrites, Parvarchaeota, Aenigmarchaeota, Nanoarchaeota and Nanohaloarchaeota) archaea, or Gammaproteobacteria were found only in bathypelagic samples. We noted various important taxonomic and metabolic differences between deep aphotic region of Lake Baikal and marine waters of similar depth: Betaproteobacteriales, CPR, and DPANN superphylum were only found in bathypelagic Baikal, while Deltaproteobacteria, Gammaproteobacteria, or Alphaproteobacteria prevailed in oceanic samples. The genes mediating ammonia and methane oxidation, aromatic compound degradation, or alkane/methanesulfonate monooxygenases were detected in higher numbers in deep Baikal compared to their oceanic counterparts or its own surface. Overall, depth seems to be less relevant than salinity in configuring the microbial community.
Recent Strategies in Fabrication of Gradient Hydrogels for Tissue Engineering Applications
Authors: Jo Heejung , Yoon Minhyuk , Gajendiran Mani , Kim Kyobum 
Published: December 2019

AbstractHydrogels are widely used as scaffold in tissue engineering field because of their ability to mimic the cellular microenvironment. However, mimicking a completely natural cellular environment is complicated due to the differences in various physical and chemical properties of cellular environments. Recently, gradient hydrogels provide excellent heterogeneous environment to mimic the different cellular microenvironments. To create hydrogels with an anisotropic distribution, gradient hydrogels have been widely developed by adopting several gradient generation techniques. Herein, the various gradient hydrogel fabrication techniques, including dual syringe pump systems, microfluidic device, photolithography, diffusion, and bio‐printing are summarized. As the effects of gradient 3D hydrogels with stems have been reviewed elsewhere, this review focuses principally on gradient hydrogel fabrication for multi‐model tissue regeneration. This review provides new insights into the key points for fabrication of gradient hydrogels for multi‐model tissue regeneration.
Effect of Sulfation Route and Subsequent Oxidation on Derivatization Degree and Biocompatibility of Cellulose Sulfates
Authors: Strätz Juliane , Liedmann Andrea , Heinze Thomas , Fischer Steffen , Groth Thomas 
Published: December 2019

AbstractSulfated cellulose (CS) represents an interesting biopolymer due to bioactivity comparable to heparin. However, use of CS for making surface coatings or hydrogels requires the presence of reactive groups for covalent reactions. Here, an approach is presented to oxidize cellulose sulfates for subsequent cross‐linking reactions with amino groups to form imine bonds. Cellulose is sulfated by direct sulfation or acetosulfation, followed by a Malaprade oxidation. The CS obtained is characterized by elemental analysis and 13C‐NMR spectroscopy. The resulting oxidized cellulose sulfates (oxCS) have different degrees of sulfation ranging from 0.79 to 1.13 and oxidation degrees from 0.18 to 0.34, but also different mass average molecular mass (MW). Toxicity studies are carried out with mouse 3T3 fibroblasts exposed to aqueous solutions of oxCS. The results show that all oxCS are non‐toxic at lower concentrations (0.5 mg mL−1), but with both increasing degree of oxidation and concentrations, toxic effects are observed particularly for acetosulfated and lesser for direct sulfated oxCS, which is related to a decrease in the MW of the products. It is concluded that oxCS obtained by direct sulfation with MW above 70 kDa may represent a biocompatible material for the applications suggested above.
Mechanical Deformation Mediated Transmembrane Transport
Authors: Ming Zunzhen , Pang Yan , Liu Jinyao 
Published: December 2019

AbstractTransmembrane transport is essential and plays critical roles for molecule exchange for cell survival. Methods capable of mimicking and regulating transmembrane transport have transformed the ability to create biosensors, separation membranes, and drug carriers. However, artificial channels have been largely restricted by their complicated chemical fabrication and inefficiency to dynamically manipulate the transport process. Here, a novel approach to regulate transmembrane transport is described by simply adjusting the mechanical deformation of liposomal bilayers which are covalently embedded in a crosslinked hydrogel network. This new approach is able to dynamically control transmembrane transport by stretching and loosening. The transmembrane diffusion of molecules can be switched on and off, and precisely tuned by varying strain. A potential of this method to programmably regulate cell growth is demonstrated by tuning external mechanical force. Given its unique characteristics, this method allows the development of innovative systems for controlled transmembrane transport of molecules.
A novel de novo nonsense mutation in ZC4H2 causes Wieacker‐Wolff Syndrome
Authors: Wang Dan , Hu Dongjie , Guo Zhichao , Hu Rong , Wang Qunxian , Liu Yannan , Liu Mingjing , Meng Zijun , Yang Huan , Zhang Yun , Cai Fang , Zhou Weihui , Song Weihong 
Published: December 2019

AbstractBackgroundWieacker‐Wolff syndrome (WWS) is a congenital X‐linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2‐type containing (ZC4H2) gene has been found to be associated with the disease pathogenesis. However, the underlying mechanism remains elusive.MethodsWhole‐exome sequencing was performed to identify the mutations. Expression plasmids were constructed and cell culture and immune‐biochemical assays were used to examine the effects of the mutation.ResultsWe reported a female patient with classical symptoms of WWS and discovered a novel nonsense heterozygous mutation (p.R67X; c.199C>T) in ZC4H2 gene in the patient but not in her parents. The mutation resulted in a 66 amino‐acid truncated ZC4H2 protein. The mutation is located in the key helix domain and it altered the subcellular locations of the mutant ZC4H2 protein. X‐chromosome inactivation (XCI) pattern analysis revealed that the XCI ratio of the proband was 22:78.ConclusionFemale heterozygous carriers with nonsense mutation with a truncated ZC4H2 protein could lead to the pathogenesis of Wieacker‐Wolff syndrome and our study provides a potential new target for the disease treatment.
Identification of RNPC3 as a novel JAK2 fusion partner gene in B‐acute lymphoblastic leukemia refractory to combination therapy including ruxolitinib
Authors: Chen Xue , Wang Fang , Zhang Yang , Ma Xiaoli , Liu Mingyue , Cao Panxiang , Zhou Lin , Wang Lan , Zhang Xian , Wang Tong , Liu Hongxing 
Published: December 2019

AbstractBackgroundHematopoietic neoplasms with chromosomal translocations involving JAK2 are rare, and most of them show myeloproliferative neoplasm‐associated features, followed by B‐acute lymphoblastic leukemia (B‐ALL). De novo B‐ALL cases with JAK2 rearrangements are suggested to be appropriately considered as BCR‐ABL1‐like B‐ALL, but its partners varied.MethodsFluorescence in situ hybridization (FISH), RNA sequencing (RNA‐Seq), whole‐genome sequencing, and reverse transcription polymerase chain reaction (RT‐PCR) were performed to identify the pathogenic fusion gene in a 29‐year‐old woman with relapsed B‐ALL and rare t(1;9)(p13;p22) translocation.ResultsWe identified RNPC3 as a new JAK2 fusion partner in the patient. She was treated with a combination of chemotherapy and targeted drug ruxolitinib and chimeric antigen receptor T‐cell therapy, but failed to achieve complete remission. She had no chance to undergo allogeneic hematopoietic stem cell transplantation and died of disease progression 7 months after the initial diagnosis. Her clinical course demonstrated that this novel RNPC3‐JAK2 fusion might portend an unfavorable prognosis.ConclusionThis finding adds to the expanding compendium of JAK2 fusions found in B‐ALL and suggests the potential need for a diagnostic FISH analysis as well as RNA‐Seq in the appropriate clinical setting.
DC‐AL GAN: Pseudoprogression and true tumor progression of glioblastoma multiform image classification based on DCGAN and AlexNet
Authors: Li Meiyu , Tang Hailiang , Chan Michael D. , Zhou Xiaobo , Qian Xiaohua 
Published: December 2019

PurposePseudoprogression (PsP) occurs in 20–30% of patients with glioblastoma multiforme (GBM) after receiving the standard treatment. PsP exhibits similarities in shape and intensity to the true tumor progression (TTP) of GBM on the follow‐up magnetic resonance imaging (MRI). These similarities pose challenges to the differentiation of these types of progression and hence the selection of the appropriate clinical treatment strategy.MethodsTo address this challenge, we introduced a novel feature learning method based on deep convolutional generative adversarial network (DCGAN) and AlexNet, termed DC‐AL GAN, to discriminate between PsP and TTP in MRI images. Due to the adversarial relationship between the generator and the discriminator of DCGAN, high‐level discriminative features of PsP and TTP can be derived for the discriminator with AlexNet. We also constructed a multifeature selection module to concatenate features from different layers, contributing to more powerful features used for effectively discriminating between PsP and TTP. Finally, these discriminative features from the discriminator are used for classification by a support vector machine (SVM). Tenfold cross‐validation (CV) and the area under the receiver operating characteristic (AUC) were applied to evaluate the performance of this developed algorithm.ResultsThe accuracy and AUC of DC‐AL GAN for discriminating PsP and TTP after tenfold CV were 0.920 and 0.947. We also assessed the effects of different indicators (such as sensitivity and specificity) for features extracted from different layers to obtain a model with the best classification performance.ConclusionsThe proposed model DC‐AL GAN is capable of learning discriminative representations from GBM datasets, and it achieves desirable PsP and TTP classification performance superior to other state‐of‐the‐art methods. Therefore, the developed model would be useful in the diagnosis of PsP and TTP for GBM.
Promoting adherence in adolescents and young adults with cancer to optimize outcomes: A developmentally oriented narrative review
Authors: Vandermorris Ashley , Sampson Lorna , Korenblum Chana 
Published: December 2019

AbstractAdherence is a critical consideration in ongoing efforts to improve outcomes among adolescents and young adults (AYAs) with cancer. In this narrative review, we embed existing conceptualizations of adherence within a developmental context to provide a novel vantage point from which to examine this important issue. Applying this developmentally oriented framework, we summarize the most current literature on strategies to enhance adherence in the AYA population. A developmentally informed approach to working with AYAs can elucidate unique strengths and vulnerabilities of this population and offer a new perspective on opportunities to respond to biopsychosocial barriers to adherence in a strengths‐based, collaborative manner.
Preparation and properties of polyurethane rigid foam materials modified by microencapsulated phase change materials
Authors: Xiang Hongxia , An Jiaxuan , Zeng Xiaoyan , Liu Xiaoxiang , Li Youbing , Yang Chaolong , Xia Xiaochao 
Published: December 2019

AbstractPolyurethane rigid foam composites are prepared via in situ foaming the polyurethane prepolymer blended with microencapsulated phase change material (MEPCM) in the work. The MEPCM is composed of n‐octadecane as core material and silicon dioxide as shell material synthesized by chemical precipitation method. Fourier transformation infrared spectroscopy (FT‐IR) and X‐ray diffraction (XRD) indicate that there are no chemical reactions between core and shell of the MEPCMs, and whose average diameter is ca. 0.69 μm investigated by scanning electron microscope (SEM). The encapsulation rate of the MEPCM is up to 47.5% calculated by differential scanning calorimeter (DSC) parameters, and the decomposition temperature of the encapsulated octadecane increased by about 20°C according to the thermogravimetric analyzer (TGA) analysis. The thermal controlling ability of polyurethane rigid foam with the MEPCMs is tested by a self‐made heating and/or cooling device, and the results showed that the foamed composites presented greater than 50 J/g for the latent heat enthalpy value and a relatively constant temperature ranged from 26°C to 28°C when the MEPCMs is 50 wt%.
An experimental study on performance of jute‐polyester composite tubes under axial and transverse impact loading
Authors: Mache Ashok , Deb Anindya , Gupta Narinder 
Published: December 2019

AbstractThe efficacy of woven jute‐polyester (JP) composite tubes as structural energy‐absorbing countermeasures has been explored in the current study. In this connection, the behaviors of 3‐ply and 4‐ply JP composite tubes of square and double‐hat shaped sections subjected to axial quasi‐static and impact loads are considered, and compared with 4‐ply glass‐polyester (GP) tubes of similar geometric configurations. Initially, basic mechanical characterization of JP laminates is carried out using a Universal Testing Machine, which is followed up with axial quasi‐static and drop‐weight impact testing of JP tubes, along with similar tests carried out on GP tubes. A thorough comparison is made between the performances including failure patterns of JP and GP components under axial loading using metrics such as peak load, mean crush load, absorbed energy, and specific energy absorption (SEA). As many structural applications involve dynamic bending loads, a comparative study is carried out between double‐hat JP and GP components subjected to transverse impact loading. Based on the competitive values of mean load and SEA yielded by jute‐composite tubes in the present study for axial impact loading, and high mean load and moderate energy absorption till failure recorded by similar components under three‐point impact bending, it can be concluded that JP tubes can be capable of supporting impact loads under both axial and bending modes.
Potential Clinical Relevance of Differences in Allele Frequencies Found within Very Important Pharmacogenes between Hmong and East Asian Populations
Authors: Wen Ya‐Feng , Culhane‐Pera Kathleen A. , Thyagarajan Bharat , Bishop Jeffrey R. , Zierhut Heather , Lo Muaj , Xiong Txia , Peng Kerui , Holzer Katherine , Lee Koobmeej , Straka Robert J. 
Published: December 2019

ObjectivesImplementing pharmacogenetics for very important pharmacogenes (VIPs) holds the promise of improving clinical outcomes through optimal medication selection and dosing. However, significant differences in the frequency of actionable variants in VIPs may exist within subpopulations of a given ancestral group. Furthermore, these differences can potentially impact drug selection and dosing. The purpose of this study was to ascertain allele frequencies for VIPs and to predict medication requirements using Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines in Hmong and compare with published data for East Asians.MethodsUsing a community‐based participatory action research approach, DNA collected from 194 Hmong adults living in the United States was analyzed for 22 genetic variants within eight VIPs (CYP2C9, CYP2C19, CYP4F2, DPYD, G6PD, SLCO1B1, TPMT, VKORC1). Allele frequencies for VIPs and predicted medication requirements using CPIC guidelines were compared between Hmong participants and East Asians.ResultsSignificant differences in allele frequencies between the Hmong and East Asians were found for 23% (5/22) of the CPIC‐actionable variants tested. Allele frequencies for VIPs in Hmong versus East Asians were 16.6% versus 3.4% in CYP2C9*3A, 42.2% versus 29.0% for CYP2C19*2, 0.3% versus 8.3% in CYP2C19*3, 6.5% versus 22.1% in CYP4F2*3, and 3.6% versus 0.1% in SLCO1B1*5, respectively. These differences significantly influenced predicted medication usage recommendations in warfarin, simvastatin, and phenytoin between Hmong and East Asians.ConclusionsImportant differences in allele frequencies for key genetic variants influencing selection of medications and dosages were found between the Hmong and East Asians. The magnitude and nature of these differences can be expected to result in different medication recommendations for the Hmong relative to East Asians.
Support, interventions and outcomes for families/carers of people with borderline personality disorder: A systematic review
Authors: Sutherland Ruth , Baker John , Prince Sharon 
Published: December 2019

AbstractIt is clear from existent literature that families and carers of relatives and friends with borderline personality disorder (BPD) experience high levels of burden. Whilst family interventions are considered vital to improving the outcomes of those with a range of mental health difficulties, there has been limited development of direct interventions for carers of people with BPD, despite a high level of need. This systematic review aimed to appraise and synthesize the existing research evidence for interventions for carers of people with BPD. Ten studies were included that were directly related to six interventions for families and carers of people with personality disorder. The findings of these studies, whilst limited, do provide some initial evidence that interventions for carers may lead to significant outcomes for the participants, particularly in improving carer well‐being and reducing carer burden. © 2019 John Wiley & Sons, Ltd.
Characterization of the various functional pathways elicited by synthetic agonists or antagonists at the melatonin MT1 and MT2 receptors
Authors: Legros Céline , Dupré Clémence , Brasseur Chantal , Bonnaud Anne , Bruno Olivier , Valour Damien , Shabajee Preety , Giganti Adeline , Nosjean Olivier , Kenakin Terrence P. , Boutin Jean A. 
Published: December 2019

AbstractMelatonin is a neurohormone that translates the circadian rhythm to the peripheral organs through a series of binding sites identified as G protein‐coupled receptors MT1 and MT2. Due to minute amounts of receptor proteins in target organs, the main tool of studies of the melatoninergic system is recombinant expression of the receptors in cellular hosts. Although a number of studies exist on these receptors, studies of several signaling pathways using a large number of melatoninergic compounds are rather limited. We chose to fill this gap to better describe a panel of compounds that have been only partially characterized in terms of functionality. First, we characterized HEK cells expressing MT1 or MT2, and several signaling routes with melatonin itself to validate the approach: GTPγS, cAMP production, internalization, β‐arrestin recruitment, and cell morphology changes (CellKey®). Second, we chose 21 compounds from our large melatoninergic chemical library and characterized them using this panel of signaling pathways. Notably, antagonists were infrequent, and their functionality depended largely on the pathway studied. This will permit redefining the availability of molecular tools that can be used to better understand the in situ activity and roles of these receptors.