bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNORA71B promotes breast cancer cells across blood–brain barrier by inducing epithelial-mesenchymal transition
Authors: Duan Sijia , Luo Xuliang , Zeng Huihui , Zhan Xiang , Yuan Chunlei 
Published: May 2020

Abstract
Background
Brain metastasis (BM) is a dreadful complication that significantly impacts the quality of life in breast cancer patients. A key process during brain metastasis is the migration of cancer cells across blood–brain barrier (BBB). However, the role of snoRNAs regulating BBB in BM is still unknown.

Methods
Here SNORic and GEO databases were used to identify differentially expressed snoRNAs between brain metastatic and non-metastatic breast cancer (BC) tissues. The effects of SNORA71B on the capacities of proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and BBB invasion of BC cells were evaluated by CCK8, transwell, western blot, and BBB model, respectively.

Results
SNORA71B was highly expressed in high BM BC tissues and cells compared to low BM BC controls. Survival analysis revealed high expression of SNORA71B was significantly associated with poor PPS and OS in breast cancer patients. ROC curve showed that SNORA71B might act as biomarker for breast cancer. Moreover, SNORA71B significantly promoted proliferation, migration, and invasion of BC cells with different BM abilities. Importantly, SNORA71B promoted the EMT process of low BM BC cells. SNORA71B knockdown inhibited the high BM BC cells across BBB, while EMT activator dramatically abrogated this inhibited effect.

Conclusions
In conclusion, SNORA71B promotes BC cells across the BBB partly via inducing EMT.
Dynamic Spatio-Temporal Tweet Mining for Event Detection: A Case Study of Hurricane Florence
Authors: Farnaghi Mahdi , Ghaemi Zeinab , Mansourian Ali 
Published: May 2020

AbstractExtracting information about emerging events in large study areas through spatiotemporal and textual analysis of geotagged tweets provides the possibility of monitoring the current state of a disaster. This study proposes dynamic spatio-temporal tweet mining as a method for dynamic event extraction from geotagged tweets in large study areas. It introduces the use of a modified version of ordering points to identify the clustering structure to address the intrinsic heterogeneity of Twitter data. To precisely calculate the textual similarity, three state-of-the-art text embedding methods of Word2vec, GloVe, and FastText were used to capture both syntactic and semantic similarities. The impact of selected embedding algorithms on the quality of the outputs was studied. Different combinations of spatial and temporal distances with the textual similarity measure were investigated to improve the event detection outcomes. The proposed method was applied to a case study related to 2018 Hurricane Florence. The method was able to precisely identify events of varied sizes and densities before, during, and after the hurricane. The feasibility of the proposed method was qualitatively evaluated using the Silhouette coefficient and qualitatively discussed. The proposed method was also compared to an implementation based on the standard density-based spatial clustering of applications with noise algorithm, where it showed more promising results.
STAR-EM: An innovative summer research program for medical students
Authors: Friedman Steven Marc , Porplycia Danielle 
Published: May 2020

ABSTRACTWe describe a novel 10-week summer research program aimed at developing academic emergency medicine (EM) interest among medical students. A cohort of students was recruited to participate in the Summer Training and Research in Emergency Medicine (STAR-EM) program with the primary goal of completing and disseminating a scholarly project. Curriculum development and program evaluation were informed by Kern's model and Kirkpatrick's hierarchy, respectively. Students and faculty demonstrated interest in academic EM and research productivity during the curriculum. This program provides a model for other emergency departments seeking to foster the development of academic EM at their institution.
Suicide on Facebook-the tales of unnoticed departure in Bangladesh
Authors: Soron Tanjir Rashid , Shariful Islam Sheikh Mohammed 
Published: May 2020

AbstractFacebook has transformed social communication and offers the opportunity to share personal thoughts to people including suicide ideas, plans and attempts. Suicide after Facebook posts has been reported in different parts of the world and it has become a potential area of research for suicide prevention. The analysis of Facebook posts prior to suicide or Facebook live streaming may help in understanding the etiological factors, patterns of communication and possible prevention approaches for a particular community. However, there is a dearth of evidence about suicide incidents after Facebook posts and Facebook live streaming in low and middle-income countries. This study aims to explore the trends and phenomena of suicide after Facebook posts and live streaming in Bangladesh. We conducted an online search using the Google, Facebook and five daily online newspaper archives from 15th August to 15th September 2019. Two research assistants independently conducted the initial searching to find out people who committed suicide after Facebook posts or live streamed suicide in Bangladesh and documented 21 cases. After further evaluation of each of the 21 cases we confirmed 19 cases that met the selection criteria. All of them were under 35-years of age. We observed sucide after Facebook posts were more common in male(78%) e and students. Hanging was the most frequently used method of suicide followed by poisoning. Their Facebook posts and livestream videos indicated relationship problems, academic stress and mental disorders were the common stressors for their suicide. This study lays the foundation for the future researchers to work on suicidal posts on Facebook in Bangladesh and develop culture-specific, real-time suicide preventive systems using a social media platform.
A randomized clinical trial to assess the efficacy of trial-based cognitive therapy compared to prolonged exposure for post-traumatic stress disorder: preliminary findings
Authors: Duran Érica Panzani , Corchs Felipe , Vianna Andrea , Araújo Álvaro Cabral , Del Real Natália , Silva Cláudio , Ferreira Ana Paula , De Vitto Francez Paula , Godói Cláudio , Silveira Helena , Matsumoto Lina , Gebara Cristiane Maluhy , de Barros Neto Tito Paes , Chilvarquer Raquel , de Siqueira Luciana Lima , Bernik Marcio , Neto Francisco Lotufo 
Published: May 2020

AbstractBackgroundPost-traumatic stress disorder (PTSD) is a prevalent mental health condition that is often associated with psychiatric comorbidities and changes in quality of life. Prolonged exposure therapy (PE) is considered the gold standard psychological treatment for PTSD, but treatment resistance and relapse rates are high. Trial-based cognitive therapy (TBCT) is an effective treatment for depression and social anxiety disorder, and its structure seems particularly promising for PTSD. Therefore, we evaluated the efficacy of TBCT compared to PE in patients with PTSD.MethodsNinety-five patients (77.6% females) who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, criteria for PTSD were randomly assigned to receive either TBCT (n = 44) or PE (n = 51). Patients were evaluated before and after treatment, and at follow-up 3 months after treatment. The primary outcome was improvement in PTSD symptoms as assessed by the Davidson Trauma Scale (DTS). Secondary outcomes were depression, anxiety, and dysfunctional attitudes assessed by the Beck Depression/Anxiety Inventories and Dysfunctional Attitudes Scale, as well as the dropout rate.ResultsA significant reduction in DTS scores was observed in both arms, but no significant difference between treatments. Regarding the secondary outcomes, we found significant differences in depressive symptoms in favor of TBCT, and the dropout rate was lower in the TBCT group than the PE group.ConclusionOur preliminary results suggest that TBCT may be an effective alternative for treating PTSD. Further research is needed to better understand its role and the mechanisms of change in the treatment of this disorder.
Gaze and eye movement in dialogue interpreting: An eye-tracking study
Authors: Tiselius Elisabet , Sneed Kayle 
Published: May 2020

AbstractPrevious studies have investigated the cognitive processes of simultaneous interpreting and translation using eye-tracking. No study has yet utilized eye-tracking to investigate cognitive load and cognitive effort in dialogue interpreting. An eye-tracking study was conducted on two groups of interpreters (experienced and inexperienced) with varying language backgrounds during a staged dialogue interpreting session. The aim of the study was to explore gaze patterns in dialogue interpreting in relation to the interpreters’ action and translation direction. The results indicated there were differences in gaze patterns depending on the action and the language used. Participants averted gaze more when interpreting into the allophone language (the L2 for a majority of the participants in this study). This may indicate that interpreting into L2 in a dialogue may involve more cognitive effort than interpreting into L1. Finally, gaze patterns did not differ significantly between inexperienced and experienced dialogue interpreters.
A Brief History of the Collaboration between Dr Nathan Gillespie and Professor Nick Martin Including Personal Reflections
Authors: Gillespie Nathan A. 
Published: May 2020

AbstractThis article describes Dr Nathan Gillespie’s PhD training and supervision under Professor Nick Martin and their ongoing collaborations. Drs Gillespie and Martin have collaborated on numerous biometrical genetic analyses applied to cross-sectional and longitudinal twin data, combined molecular and phenotypic modeling, as well as genomewide meta-analyses of psychoactive substance use and misuse. Dr Gillespie remains an active collaborator with Professor Martin, including ongoing data collection, analysis and publications related to the Brisbane Longitudinal Twin Study.
Impact of postemergence herbicides on soybean injury and canopy formation
Authors: Priess Grant L. , Norsworthy Jason K. , Roberts Trenton L. , Gbur Edward E. 
Published: May 2020

AbstractField studies were conducted in 2017 and 2018 in Arkansas to evaluate the injury caused by herbicides on soybean canopy formation and yield. Fomesafen, acifluorfen, S-metolachlor + fomesafen, and S-metolachlor + fomesafen + chlorimuron alone and in combination with glufosinate were applied to glufosinate-resistant soybean at the V2 growth stage. Soybean injury resulting from these labeled herbicide treatments ranged from 9% to 25% at 2 wk after application. This level of injury resulted in a 4-, 5-, 6-, and 6-d delay in soybean reaching 80% groundcover following fomesafen, acifluorfen, S-metolachlor + fomesafen, and S-metolachlor + fomesafen + chlorimuron, respectively. There was a 2-d delay in soybean reaching a canopy volume of 15,000 cm3 following each of the four herbicide treatments. The addition of glufosinate to the herbicide applications resulted in longer delays in canopy formation with every herbicide treatment except glufosinate + fomesafen. Fomesafen, acifluorfen, S-metolachlor + fomesafen, and S-metolachlor + fomesafen + chlorimuron, each applied with glufosinate, delayed soybean from reaching 80% groundcover by 2, 7, 8, and 9 d, respectively, and delayed the number of days for soybean to reach a canopy volume of 15,000 cm3 by 2, 3, 2, and 2 d, respectively. No yield loss occurred with any herbicide application. A delay in percent groundcover in soybean allows sunlight to reach the soil surface for longer periods throughout the growing season, possibly promoting late-season weed germination and the need for an additional POST herbicide application.
Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience
Authors: Pilone Vincenzo , Tramontano Salvatore , Cutolo Carmen , Marchese Federica , Pagano Antonio Maria , Di Spirito Federica , Schiavo Luigi 
Published: May 2020

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.
Relationships Between Supermicrometer Sea Salt Aerosol and Marine Boundary Layer Conditions: Insights From Repeated Identical Flight Patterns
Authors: Schlosser Joseph S. , Dadashazar Hossein , Edwards Eva‐Lou , Hossein Mardi Ali , Prabhakar Gouri , Stahl Connor , Jonsson Haflidi H. , Sorooshian Armin 
Published: May 2020

AbstractThe MONterey Aerosol Research Campaign (MONARC) in May–June 2019 featured 14 repeated identical flights off the California coast over the open ocean at the same time each flight day. The objective of this study is to use MONARC data along with machine learning analysis to evaluate relationships between both supermicrometer sea salt aerosol number (N>1) and volume (V>1) concentrations and wind speed, wind direction, sea surface temperature (SST), ambient temperature (Tamb), turbulent kinetic energy (TKE), relative humidity (RH), marine boundary layer (MBL) depth, and drizzle rate. Selected findings from this study include the following: (i) Near surface (<60 m) N>1 and V>1 concentration ranges were 0.1–4.6 cm−3 and 0.3–28.2 μm3 cm−3, respectively; (ii) four meteorological regimes were identified during MONARC with each resulting in different N>1 and V>1 concentrations and also varying horizontal and vertical profiles; (iii) the relative predictive strength of the MBL properties varies depending on predicting N>1 or V>1, with MBL depth being more highly ranked for predicting N>1 and with TKE being higher for predicting V>1; (iv) MBL depths >400 m (<200 m) often correspond to lower (higher) N>1 and V>1 concentrations; (v) enhanced drizzle rates coincide with reduced N>1 and V>1 concentrations; (vi) N>1 and V>1 concentrations exhibit an overall negative relationship with SST and RH and an overall positive relationship with Tamb; and (vii) wind speed and direction were relatively weak predictors of N>1 and V>1.
Effect on Subduction of Deeply Buried Seamounts Offshore of Kodiak Island
Authors: Frederik Marina C. G. , Gulick Sean P. S. , Miller John J. 
Published: May 2020

AbstractSeamounts are ubiquitous on the oceanic plate; those situated near convergent margins will eventually undergo subduction. Using six prestack depth migrated MCS profiles transecting the Aleutian Trench, we investigate deeply buried seamounts offshore Kodiak Island, within 145–155°W and 55–58°N. A distinct sedimentary horizon exists in all six seismic profiles, at or above the average height of seamounts, which appears to be the preferred structural detachment zone. Where drilled, this horizon contains gravel‐sized debris interpreted to be ice rafted and marks the onset of intensification of Northern Hemisphere glaciation at ~2.7 Ma. Beneath this horizon, sediments prior to the Surveyor Fan development were deposited, all or the majority of these sediments will eventually be subducted. Despite the subducted seamounts being deeply buried, these features cause enhanced surface slope of the accretionary prism. Our observations lead us to propose a model for the stages of subduction for deeply buried seamounts. These stages include the following: (1) Prior to subduction, the protothrust zone undergoes enhanced shortening, (2) frontal thrust steepening and enhanced backthrusting occurs during subduction with a potential décollement step down seaward and a steeping outward of the deformation front to the limit of the protothrust zone, and (3) further subduction results in a pattern of uplift farther into the wedge resulting in enhanced out‐of‐sequence thrusting and persistence of the more seaward deformation front position. This pattern is distinct from the dominance of embayments and effective removal of prism material during seamount subduction described along margins with less deeply buried edifices.
Muztaghata Dome Miocene Eclogite Facies Metamorphism: A Record of Lower Crustal Evolution of the NE Pamir
Authors: Li Yi‐Peng , Robinson Alexander C. , Lapen Thomas J. , Righter Minako , Stevens Michael K. 
Published: May 2020

AbstractThe Pamir gneiss domes represent the most extensive exposure of mid to lower crustal rocks in the Himalayan‐Tibetan orogen north of the India‐Asia suture zone. Unlike other domes in the Central and Southern Pamir, the Muztaghata dome stands out due to its higher metamorphic grade, more complex structural elements, and variable timing of metamorphism. In order to unravel the P‐T‐t history of the Muztaghata dome and better constrain the timing of peak metamorphism, we applied petrologic modeling in concert with geochronology to samples from the structure. The Muztaghata gneiss dome is composed of a structurally higher metapelite‐dominated terrane in the west and a structurally lower orthogneiss terrane in the east. Our results from the western terrane indicate high‐pressure eclogite facies peak conditions of ~800°C/22 kbar at ~25–20 Ma. Zircon grains from metapelitic samples from the western terrane also yield Early Jurassic metamorphic U‐Pb ages with REE signals that indicate coeval garnet growth. Our results from the eastern terrane record high‐pressure amphibolite facies peak conditions of ~650°C/14 kbar at ~24–20 Ma, noticeably lower than the structurally higher western terrane indicating structural juxtaposition during Miocene exhumation. Peak metamorphic conditions from the eastern terrane indicate depths below the current Moho, supporting the interpretation that the Early Miocene Pamir crust was thicker than present. This was followed by rapid exhumation from depths of ~75–80 km and partial westward collapse of the Pamir after 20 Ma, possibly driven in part by regional lithospheric delamination.
Assessment and Prediction of Pore‐Scale Reactive Mixing From Experimental Conservative Transport Data
Authors: Perez Lazaro J. , Hidalgo Juan J. , Puyguiraud Alexandre , Jiménez‐Martínez Joaquín , Dentz Marco 
Published: May 2020

AbstractWe investigate the impact of pore‐scale heterogeneity on reactive mixing using experimental data from inert fluid‐fluid displacement in a quasi 2‐D porous medium. We interpret the invading and defending fluids as the conservative components A+C and B+C of the instantaneous irreversible bimolecular chemical reaction A+B→C and determine the reaction product C. We find strong growth of the reaction rate at short and intermediate times due to deformation of the mixing interface and heterogeneity‐induced increase of the mixing area. This behavior is captured by a dispersive lamella approach that quantifies the mixing dynamics at the interface in terms of temporally evolving effective dispersion coefficients. The latter capture the dominant controls on the evolution of the mixing interface, namely, advective heterogeneity and transverse mixing. Reactive transport formulations based on constant hydrodynamic dispersion coefficients are not able to describe the observed behavior due to the lack of complete mixing on the support scale, which is required for these approaches to hold. These results shed some new light on the origins of heterogeneity‐induced mixing and reaction dynamics in porous media and their systematic upscaling.
Global distribution of a chlorophyll f cyanobacterial marker
Authors: Antonaru Laura A , Cardona Tanai , Larkum Anthony W D , Nürnberg Dennis J 
Published: May 2020

Abstract
Some cyanobacteria use light outside the visible spectrum for oxygenic photosynthesis. The far-red light (FRL) region is made accessible through a complex acclimation process that involves the formation of new phycobilisomes and photosystems containing chlorophyll f. Diverse cyanobacteria ranging from unicellular to branched-filamentous forms show this response. These organisms have been isolated from shaded environments such as microbial mats, soil, rock, and stromatolites. However, the full spread of chlorophyll f-containing species in nature is still unknown. Currently, discovering new chlorophyll f cyanobacteria involves lengthy incubation times under selective far-red light. We have used a marker gene to detect chlorophyll f organisms in environmental samples and metagenomic data. This marker, apcE2, encodes a phycobilisome linker associated with FRL-photosynthesis. By focusing on a far-red motif within the sequence, degenerate PCR and BLAST searches can effectively discriminate against the normal chlorophyll a-associated apcE. Even short recovered sequences carry enough information for phylogenetic placement. Markers of chlorophyll f photosynthesis were found in metagenomic datasets from diverse environments around the globe, including cyanobacterial symbionts, hypersaline lakes, corals, and the Arctic/Antarctic regions. This additional information enabled higher phylogenetic resolution supporting the hypothesis that vertical descent, as opposed to horizontal gene transfer, is largely responsible for this phenotype’s distribution.
Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex
Authors: Seo Jinho , Seong Daehyeon , Nam Young Woo , Hwang Chi Hyun , Lee Seung Ri , Lee Choong-Sil , Jin Young , Lee Han-Woong , Oh Doo-Byoung , Vandenabeele Peter , Song Jaewhan 
Published: May 2020

AbstractNecroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood. Here, we identified that Beclin 1 functions as an anti-necroptosis factor by being recruited into the necrosome complex upon treatment with TNFα, Smac mimetic, and pan-caspase inhibitor and by repressing MLKL oligomerisation, thus preventing the disruption of the plasma membrane. Cells ablated or knocked-out for Beclin 1 become sensitised to necroptosis in an autophagy-independent manner without affecting the necrosome formation itself. Interestingly, the recruitment of Beclin 1 into the necrosome complex is dependent on the activation and phosphorylation of MLKL. Biochemically, the coiled-coil domain (CCD) of Beclin 1 binds to the CCD of MLKL, which restrains the oligomerisation of phosphorylated MLKL. Finally, Beclin 1 depletion was found to promote necroptosis in leukaemia cells and enhance regression of xenografted-tumour upon treatment with Smac mimetics and caspase inhibitors. These results suggest that Beclin 1 functions as a negative regulator in the execution of necroptosis by suppressing MLKL oligomerisation.