bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dependence, Transcendence, and Creaturely Freedom: On the Incompatibility of Three Theistic Doctrines
Authors: Segal Aaron 
Published: November 2019

AbstractIn this paper I argue for the incompatibility of three claims, each of them quite attractive to a theist. First, the doctrine of deep dependence: the universe depends for its existence, in a non-causal way, on God. Second, the doctrine of true transcendence: the universe is wholly distinct from God; God is separate and apart from the universe in respect of mereology, modes, and mentality. Third, the doctrine of robust creaturely freedom: some creature performs some act such that he could have done other than he in fact did. After laying out the claims, I show that their conjunction has its adherents—most clearly, the medieval Jewish philosopher, Maimonides. I then argue in detail that the claims are in fact incompatible. I conclude with a discussion of which of the claims is best jettisoned, drawing in part on the work of the Absolute Idealist, Mary Calkins.
Encephalitozoon intestinalis: A new target for auranofin in a mice model
Authors: Abou-El-Naga I F , Gaafar M R , Gomaa M M , Khedr S I , Achy S N El 
Published: November 2019

AbstractDespite the fact that many approaches have been developed over years to find efficient and well-tolerated therapeutic regimens for microsporidiosis, the effectiveness of current drugs remains doubtful, and effective drugs against specific targets are still scarce. The present study is the first that was designed to evaluate the potency of auranofin, an anti-rheumatoid FDA approved drug, against intestinal Encephalitozoon intestinalis. Evaluation of the drug was achieved through counting of fecal and intestinal spores, studying the intestinal histopathological changes, measuring of intestinal hydrogen peroxide level, and post therapy follow-up of mice for 2 weeks for detection of relapse. Results showed that auranofin has promising anti-microsporidia potential. It showed a promising efficacy in mice experimentally infected with E. intestinalis. It has revealed an obvious reduction in fecal spore shedding and intestinal tissue spore load, amelioration of intestinal tissue pathological changes, and improvement of the local inflammatory infiltration without significant changes in hydrogen peroxide level. Interestingly, auranofin prevented the relapse of infection. Thus, considering the results of the present work, auranofin could be considered a therapeutic alternative for the gold standard drug ‘albendazole’ against the intestinal E. intestinalis infection especially in relapsing cases.
‘Loving Capitalism Disease’: Aids and Ideology in the People’s Republic of China, 1984–2000*
Authors: Gewirtz Julian 
Published: November 2019

Abstract
This article examines how the Chinese Communist Party (CCP) interpreted HIV/AIDS in the period from 1984, when the Chinese government first introduced policies reacting to the disease’s emergence, to 2000, when China’s devastating epidemic began to receive worldwide media attention. Important new sources show how the CCP cast HIV/AIDS as a staging ground for debates about the risks of liberalization and an evolving metaphor for deviance from socialism even in an era of capitalistic changes. Just as anti-capitalist ideology shaped official understandings of HIV/AIDS, so too did HIV/AIDS shape official views about the perils of China’s ‘reform and opening’ and the risks of capitalism to China. This two-way flow of meanings, which carried epidemiological and human consequences, illustrates the need for scholars of this period to foreground the evolving official ideology and forms of resistance to global capitalism — in politics, culture, society and even public health — rather than only the more common and sanguine narrative of rapid growth and economic development. Far more than previously understood, the interplay between AIDS and CCP ideology in this period reveals crucial dynamics in the evolution of China’s ongoing encounter with global capitalism.
The role of foundations in family governance
Authors: Jakob Dominique 
Published: November 2019

Abstract
Family businesses nowadays face numerous challenges caused by multinational family structures, the interplay of generations and inheritance law. This article deals with the role that foundations can play in safeguarding family governance within family businesses. It explains the various models of how foundations can be used as holding structures for businesses. However, as the force of law is limited, the article then focuses on how to integrate family values into the legal tools and attempts to identify the right questions that have to be addressed in order to successfully combine solid legal structures with sustainable family happiness.
The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome
Authors: Zhang Mei‐Juan , Zhao Qiu‐Chen , Xia Ming‐Xu , Chen Jian , Chen Yan‐Ting , Cao Xiang , Liu Yi , Yuan Zeng‐Qiang , Wang Xiao‐Ying , Xu Yun 
Published: November 2019

AbstractHistone deacetylases 3 (HDAC3) modulates the acetylation state of histone and non‐histone proteins and could be a powerful regulator of the inflammatory process in stroke. Inflammasome activation is a ubiquitous but poorly understood consequence of acute ischemic stroke. Here, we investigated the potential contributions of HDAC3 to inflammasome activation in primary cultured microglia and experimental stroke models. In this study, we documented that HDAC3 expression was increased in microglia of mouse experimental stroke model. Intraperitoneal injection of RGFP966 (a selective inhibitor of HDAC3) decreased infarct size and alleviated neurological deficits after the onset of middle cerebral artery occlusion (MCAO). In vitro data indicated that LPS stimulation evoked a time‐dependent increase of HDAC3 and absent in melanoma 2 (AIM2) inflammasome in primary cultured microglia. Interestingly, AIM2 was subjected to spatiotemporal regulation by RGFP966. The ability of RGFP966 to inhibit the AIM2 inflammasome was confirmed in an experimental mouse model of stroke. As expected, AIM2 knockout mice also demonstrated significant resistance to ischemia injury compared with their wild‐type littermates. RGFP966 failed to exhibit extra protective effects in AIM2−/− stroke mice. Furthermore, we found that RGFP966 enhanced STAT1 acetylation and subsequently attenuated STAT1 phosphorylation, which may at least partially contributed to the negative regulation of AIM2 by RGFP966. Together, we initially found that RGFP966 alleviated the inflammatory response and protected against ischemic stroke by regulating the AIM2 inflammasome.
Discordant evolution of mitochondrial and nuclear yeast genomes at population level
Authors: De Chiara Matteo , Friedrich Anne , Barré Benjamin , Breitenbach Michael , Schacherer Joseph , Liti Gianni 
Published: November 2019

AbstractMitochondria are essential organelles partially regulated by their own genomes. The mitochondrial genome maintenance and inheritance differ from nuclear genome, potentially uncoupling their evolutionary trajectories. Here, we analysed mitochondrial sequences obtained from the 1,011 Saccharomyces cerevisiae strain collection and identified pronounced differences with their nuclear genome counterparts. In contrast with most fungal species, S. cerevisiae mitochondrial genomes show higher genetic diversity compared to the nuclear genomes. Strikingly, mitochondrial genomes appear to be highly admixed, resulting in a complex interconnected phylogeny with weak grouping of isolates, whereas interspecies introgressions are very rare. Complete genome assemblies revealed that structural rearrangements are nearly absent with rare inversions detected. We tracked introns variation in COX1 and COB to infer gain and loss events throughout the species evolutionary history. Mitochondrial genome copy number is connected with the nuclear genome and linearly scale up with ploidy. We observed rare cases of naturally occurring mitochondrial DNA loss, petite, with a subset of them that do not suffer fitness growth defects. Overall, our results illustrate how differences in the biology of two genomes coexisting in the same cells can lead to discordant evolutionary histories.
Selective attention to sound features mediates cross-modal activation of visual cortices
Authors: Retsa Chrysa , Matusz Pawel J. , Schnupp Jan W.H. , Murray Micah M. 
Published: November 2019

AbstractContemporary schemas of brain organization now include multisensory processes both in low-level cortices as well as at early stages of stimulus processing. Evidence has also accumulated showing that unisensory stimulus processing can result in cross-modal effects. For example, task-irrelevant and lateralized sounds can activate visual cortices; a phenomenon referred to as the auditory-evoked contralateral occipital positivity (ACOP). Some claim this is an example of automatic attentional capture in visual cortices. Other results, however, indicate that context may play a determinant role. Here, we investigated whether selective attention to spatial features of sounds is a determining factor in eliciting the ACOP. We recorded high-density auditory evoked potentials (AEPs) while participants selectively attended and discriminated sounds according to four possible stimulus attributes: location, pitch, speaker identity or syllable. Sound acoustics were held constant, and their location was always equiprobable (50% left, 50% right). The only manipulation was to which sound dimension participants attended. We analysed the AEP data from healthy participants within an electrical neuroimaging framework. The presence of sound-elicited activations of visual cortices depended on the to-be-discriminated, goal-based dimension. The ACOP was elicited only when participants were required to discriminate sound location, but not when they attended to any of the non-spatial features. These results provide a further indication that the ACOP is not automatic. Moreover, our findings showcase the interplay between task-relevance and spatial (un)predictability in determining the presence of the cross-modal activation of visual cortices.
Hierachical Resampling for Bagging in Multi-Study Prediction with Applications to Human Neurochemical Sensing
Authors: Loewinger Gabriel , Patil Prasad , Kishida Kenneth T. , Parmigiani Giovanni 
Published: November 2019

AbstractWe propose the “study strap ensemble,” which combines advantages of two common approaches to fitting prediction models when multiple training datasets (“studies”) are available: pooling studies and fitting one model versus averaging predictions from multiple models each fit to individual studies. The study strap ensemble fits models to bootstrapped datasets, or “pseudo-studies.” These are generated by resampling from multiple studies with a hierarchical resampling scheme that generalizes the randomized cluster bootstrap. The study strap is controlled by a tuning parameter that determines the proportion of observations to draw from each study. When the parameter is set to its lowest value, each pseudo-study is resampled from only a single study. When it is high, the study strap ignores the multi-study structure and generates pseudo-studies by merging the datasets and drawing observations like a standard bootstrap. We empirically show the optimal tuning value often lies in between, and prove that special cases of the study strap draw the merged dataset and the set of original studies as pseudo-studies. We extend the study strap approach with an ensemble weighting scheme that utilizes information in the distribution of the covariates of the test dataset.Our work is motivated by neuroscience experiments using real-time neurochemical sensing during awake behavior in humans. Current techniques to perform this kind of research require measurements from an electrode placed in the brain during awake neurosurgery and rely on prediction models to estimate neurotransmitter concentrations from the electrical measurements recorded by the electrode. These models are trained by combining multiple datasets that are collectedin vitrounder heterogeneous conditions in order to promote accuracy of the models when applied to data collected in the brain. A prevailing challenge is deciding how to combine studies or ensemble models trained on different studies to enhance model generalizability.Our methods produce marked improvements in simulations and in this application. All methods are available in thestudyStrapCRAN package.
Ground penetrating radar-based deterioration assessment of RC bridge decks
Authors: Alsharqawi Mohammed , Zayed Tarek , Shami Ahmad 
Published: November 2019

Purpose
Although ground penetrating radar (GPR) technology is commonly used to assess the condition of reinforced-concrete (RC) bridge decks, the GPR data interpretation is not straightforward. Further, the thresholds that define the severity of deterioration are selected arbitrarily. This paper aims to solve a problem associated with GPR results generated by using a numerical amplitude method to assess corrosiveness of bridge decks.

Design/methodology/approach
Data, for more than 50 different bridge decks, were collected using a ground-coupled antenna. Depth-correction was performed for the collected data to normalize the reflected amplitude. Using k-means clustering technique, the amplitude values of each bridge deck were classified into four categories. Later, statistical analysis was performed where the threshold values of different categories of corrosion and deterioration are chosen. Monte-Carlo simulation technique was used to validate the value of these thresholds. Moreover, a sensitivity analysis was performed to realize the effect of changing the thresholds in the areas of corrosion.

Findings
The final result of this research is a four-category (good, fair, poor and critical) GPR scale with three fixed numerical thresholds (−7.71 dB, −10.04 dB and −14.63 dB) that define these categories. Besides, deterioration curves have been modeled using Weibull function and based on GPR outputs and corrosion areas.

Originality/value
The developed numerical GPR-based scale and deterioration models are expected to help the decision-makers in assessing the corrosiveness of bridge decks accurately and objectively. Hence, they will be able to take the right intervention decision for managing these decks.
Using uniform magnetic field to obtain the constant output power and transfer efficiency for MCR-WPT
Authors: Liu Suqi , Tan Jianping 
Published: November 2019

PurposeThis paper aims to find an approach that achieves constant output power and transfer efficiency in an open space, such as charging pads.Design/methodology/approachIn this study, a topology of the five-coil system including two transmitting coils is presented. Also, in a fixed-frequency mode and an open space, this study focuses on the two transmitting coils to achieve the uniform magnetic field and ultimately, attain the constant output power and transfer efficiency.FindingsIn a fixed-frequency mode and an open space, the constant output power and transfer efficiency is then achieved in experiments by inserting the relay loop into the uniform magnetic field.Practical implicationsAn approach that achieves constant output power and transfer efficiency in an open space. The topology of the five-coil magnetically coupled resonant-wireless power transfer (MCR-WPT) system shows prospective value for various applications, which could be used at designing of wireless battery charger dedicated for cars or mobile phones.Originality/valueBy comparing the simulation and experimental results, the topology can be optimized in the transmission performance by itself. By doing so, the constant output power and transfer ef?ciency are achieved in the constant frequency mode.
Higher education space management through user-centric data analytics
Authors: Lavy Sarel , Daneshpour Elmira , Choi Kunhee 
Published: November 2019

Purpose
This study aims to investigate critical spatial factors that may affect the utilization rate of graduate student study space in higher education institutions (HEI). It is anticipated that the results of this study could promote research productivity by more effectively engaging research space dedicated to graduate students.

Design/methodology/approach
A comparative quantitative analysis based on survey results was implemented. The quantitative study compares the results of Department A of the university under study with other departments on the same campus. Logistic regression is used for quantitative translation of the categorical data.

Findings
Noise level and furniture quality (both for comfort and layout design) are almost equally the most significant factors for attracting graduate students to study lounges. Based on the results from this study, with quality improvements of noise level or furniture, the probability of user occupancy rates in graduate lounges would triple.

Research limitations/implications
Being a case study, the quantitative results are only applicable to the one university studied. However, the significance of noise and furniture quality as the prime factors for successful graduate study lounges could be bolstered with findings from other case studies around the nation and the world.

Originality/value
This study attempts to pay close attention to graduate lounge spaces within HEI. With the rising pressure on universities to offer greater benefits with the same space assets, this study helps facility managers create more efficient spaces at universities tailored for the modern style of education.
Analyzing causal relationships of effective factors on the decision making of individual investors to purchase shares
Authors: Sayyadi Tooranloo Hossein , Azizi Pedram , Sayyahpoor Ali 
Published: November 2019

Purpose
Changes in economic markets have made it necessary to understand the psychology of individual investors. Conducting effective studies on the decision of investors to buy stock in the stock market can be useful. Therefore, it is necessary to identify and prioritize the factors affecting the decision-making of investors to purchase shares of the stock exchange. The purpose of this study was to analyze causal relationships and to weight effective factors on individual investment to purchase shares of Tehran Stock Exchange.

Design/methodology/approach
The present study is applied research in the term of its purposes and a descriptive-survey one in the term of data gathering methods. The data required in this study was collected through library and field studies. The study population included 35 investment experts. In present study, multi-criteria decision-making techniques in type-2 fuzzy environments have been used to analyze the causal relationships and weighing the factors affecting individual investment in purchasing stock in the stock market.

Findings
In the study, 4 indicators and 20 sub-indicators influencing individual investors’ decision to purchase shares of Tehran Stock Exchange were selected based on the literature review in the field of investment in the stock exchange, as well as interviews with experts. Analyzing the opinions of experts showed that they have much paid attention to financial index compare to the economic, political and psychological indicators of the market in determining the priority of indicators. In analyzing sub-indicators, it was identified that Iranian investors pay special attention to economic and political developments, political news and international economic developments.

Research limitations/implications
The present study has been carried out in Iran, and therefore, is geographically limited to Iran. In thematic terms, it is limited to effective factors of individual investments in Tehran Stock Exchange. The statistical population of present study was limited to investing experts in Tehran Stock Exchange. The difference in financial, economic, social and political conditions of individuals was another limitation of present study. The main consequences of research were the explanation of causes of investors’ higher attention to financial factors than economic, political and mental factors of market in buying stocks.

Originality/value
Given the uncertainty in the market status, using multi-criteria decision-making techniques in financial analysis can help decision-makers to make better decisions. In addition, it would be possible to take into account many variables that do not have a mathematical aspect but are important in decision-making and lead to increased decision-making satisfaction. The research initially analyzed causal relationships of determinants of individual investment on stock exchange for buying stocks through a type-2 fuzzy approach.
Can sustainability audits provide effective, hands-on business sustainability learning, teaching and assessment for business management undergraduates?
Authors: Emblen-Perry Kay 
Published: November 2019

PurposeThis paper aims to present a novel pedagogical approach to education for sustainability within the business curriculum that adopts a sustainability audit of a fictional company presented as a case study as the focus of learning, teaching and assessment. It evaluates the user’s ability to provide the active learning called for in education for sustainability literature and hands-on learning that business management students prefer.Design/methodology/approachThis study explores students’ qualitative and quantitative responses to pre- and post-module surveys and module evaluations to establish the effectiveness of focussing learning, teaching and assessment on a sustainability audit. The study, undertaken over a two-year period, adopts four indicators of learning and teaching effectiveness to synthesise, evaluate and present the findings as follows: development of sustainability knowledge and skill, employment skills, career and life skills and engagement.FindingsThe study finds that a sustainability audit can develop students’ knowledge and skills in all four indicators of learning and teaching effectiveness. In addition, the findings suggest it can raise students’ learning awareness and recognition of their role in the learning process.Research limitations/implicationsThis paper reports the findings of a small scale, two-year study. As such, it presents indicative findings rather than generalised conclusions.Practical implicationsDesigning a pedagogical approach to education for sustainability within the business curriculum around the completion of a sustainability audit can offer hands-on learning experiences that meet students’ preferences for interactive, experiential and collaborative learning within real-world environments, employers’ demands for employment-ready graduates and educators’ hopes for sustainability advocates.Originality/valueThis study builds on the existing pedagogic discourse of pedagogic means and methods for education for sustainability within the business curriculum. It provides insight into effective hands-on education for sustainability within the business curriculum and offers experience-based guidance to educators seeking to develop immersive, active and experiential, real-world pedagogical approaches.