bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Successful Treatment 1 Year After Arthroscopic Partial Meniscectomy
Authors:   Cleveland Clinic Sports Health1
Published: October 2020

Background:
Arthroscopic partial meniscectomy (APM) is one of the most common orthopaedic procedures. Understanding factors that predict better patient-reported outcomes is important for guiding patient and clinician decision-making. The purpose of this study was to evaluate predictors of pain and function after APM in a large, multisite, academic health system cohort.

Methods:
We prospectively enrolled 665 patients who were ≥40 years of age and who had APM without any concomitant ligament or cartilage-resurfacing procedures. There were 486 subjects (73%) who completed baseline and follow-up questionnaires including demographic variables (age, sex, body mass index [BMI], education level), surgical findings (meniscal tear type, articular cartilage grade), and patient-reported outcomes (Knee injury and Osteoarthritis Outcome Score [KOOS] Pain, Physical Function Short Form [PS], and knee-related Quality of Life [QOL]; and Veterans RAND 12-Item [VR-12] Mental Component Score [MCS] and Physical Component Score [PCS]). We constructed multivariable statistical models to assess predictors of improvement in patient-reported outcomes, as well as a model to assess predictors of a successful improvement of at least 10 points in either KOOS Pain or KOOS-PS.

Results:
The mean age was 55 years, 46% of patients were female, and the mean BMI was 30 kg/m2. There were clinically important and significant improvements (p < 0.001) in all patient-reported outcomes from baseline to the 1-year follow-up. The following factors predicted less improvement in at least 1 patient-reported outcome: higher baseline score, higher BMI, older age, less education, current smoking, lower VR-12 MCS, prior ipsilateral surgical procedure, bipolar medial compartment cartilage lesions, and a lateral meniscal tear. Eighty-three percent of subjects had a successful improvement of 10 points in either KOOS Pain or KOOS-PS. The odds of successful improvement were lower in patients with a medial meniscal root tear, a lateral meniscal tear, or higher baseline KOOS Pain score.

Conclusions:
Eighty-three percent of patients improved by at least 10 points in pain and function after APM. Patients with a medial meniscal root tear or a lateral meniscal tear had decreased odds of a clinically important improvement in pain or function after APM. Increased BMI, smoking, and worse VR-12 MCS are potentially modifiable risk factors that predict less improvement after APM and warrant further study.

Level of Evidence:
Prognostic Level I. See Instructions for Authors for a complete description of levels of evidence.
Availability of Essential Commodities and Related Bottlenecks for Community Health System: Systematic Literature Review
Authors: Pradhan Ami , Bogue Erin , Schreiber Benjamin , Dini Hannah Sarah , Hurkchand Hitesh , Briggs Jane , Ballard Madeleine 
Published: October 2020

Abstract
Background: This paper explores the extent of community-level stock-out of essential and program commodities for Maternal, Newborn and Child Health (MNCH) among Community Health Workers (CHWs) in Low- and Middle-Income Countries (LMICs), and identifies the underlying bottlenecks leading to such stock-outs.

Methods: A systematic literature review was conducted of published and grey literature. 48 studies containing information on the number or percentage of CHWs or health facilities (HFs) stocked-out, or reasons for stock-outs at these levels, were included. In addition, interviews were conducted with domain experts from different organizations working on community health to identify primary reasons for stock-outs. The qualitative data regarding reasons for stock-outs were categorized under different themes, using a content analysis method.

Results: 48.09% [CI 95%: 39.28 - 56.90] of the Community Health Workers and 54.76 % [CI 95%: 43.54 - 65.98] of the health facilities in SSA countries included in this study experienced stock-outs of essential commodities. A hypothesis test showed no significant difference in stock-out rates between CHWs and HFs. The most frequently cited reason for CHW stock-outs was a lack of financial resources, leading to inadequate national level stocks, affecting supply available at the last mile. Moreover, issues at HF and CHW levels in the following areas contributed to stock-outs: transportation, data and estimation of needs, human resources, and stock management and storage. These significant bottlenecks hinder the ability of CHWs to save lives.

Conclusion: Stock-outs of health commodities impact almost half of CHWs, preventing effective service delivery. Many factors contribute to stock-outs, which occur at all levels of the health supply chain. A system strengthening approach is necessary to reduce CHW stock-outs. Sparse data, differing definitions of stock-outs, and inconsistent reporting metrics posed significant challenges to analyzing results from reviewed studies. Therefore, a set of standard metrics to measure the rate, period, and frequency of stock-outs in future studies is recommended.
Student Perspective of Classroom and Distance Learning During COVID-19 Pandemic in the Undergraduate Dental Study Program Universitas Indonesia
Authors: Amir Lisa , Tanti Ira , Maharani Diah Ayu , Wimardhani Yuniardini , Julia Vera , Sulijaya Benso , Puspitawati Ria 
Published: October 2020

Abstract
Background: The COVID-19 pandemic has become a global health issue and has had a major impact on education. Consequently, half way through the second semester of the academic year 2019/2020, learning methods were delivered through distance learning (DL). We aimed to evaluate the student perspective of DL compared to classroom learning (CL) in the undergraduate dentistry study program at the Faculty of Dentistry Universitas Indonesia. Methods: An online questionnaire was sent at the end of the semester. A total of 301 students participated in the study. Results: Duration of study influenced student preference. Higher number of first-year students preferred DL compared to their seniors ( p <0.001). Students preferred CL for group discussion, as DL resulted in more difficult communication and gave less learning satisfaction. Only 44.2% students preferred DL over CL, although they agreed that DL gave a more efficient learning method (52.6%), it provided more time to study (87.9%) and to review study materials (87.3%). Challenges during DL included external factors such as unstable internet connection, extra financial burden for the internet quota and internal factors such as time management and difficulty to focus while learning online for a longer period of time. Conclusion: Despite some challenges, dental students could adapt to the new learning methods of full DL and the majorities agreed blended learning that combined classroom and distance learning can be implemented henceforth. This current COVID-19 pandemic, changes not only the utilization of technology in education but the pedagogy strategies in the future.
Does estradiol orally and vaginally administered together impact live birth and neonatal outcomes in artificial frozen-thawed embryo transfer cycles: a retrospective cohort study
Authors: Liu Yuan , Yang Yixia , Sun Jian , Zhou Xinting , Hu Yanmei , Wu Yu 
Published: October 2020

Abstract
Background: Previous studies have demonstrated that newborns from fresh embryo transfer have higher risk of small for gestation (SGA) rate than those from frozen-thawed embryo transfer (FET). It is suggested that supraphysiologic serum estradiol in controlled ovarian stimulation (COS) is one of reasons. Our study aims to investigate whether exogenous estradiol delivered regimens have an impact on live birth rate and neonatal outcomes in hormone replacement (HRT)-FET cycles. Methods: This was a retrospective study involving patients undergoing their first FET with HRT endometrium preparation followed by the transfer of two cleavage-staged embryos, comparing estradiol administered orally and vaginally (OVE group) versus estradiol administered orally (OE group) from January 2015 to December 2018 at our center. A total of 792 patients fulfilled the criteria, including 228 live birth singletons. The live birth rate was the primary outcome measure. Secondary outcome measures included clinical pregnancy rate, singleton birthweight, large for gestational age (LGA) rate, SGA rate, preterm delivery rate. Results: Patients in OVE group achieved higher serum estradiol level with more days of estradiol treatment. No difference in live birth (Adjusted OR 1.327; 95%CI 0.982, 1.794, p = 0.066) and clinical pregnancy rate (Adjusted OR 1.278; 95%CI 0.937, 1.743, p = 0.121) was found between OVE and OE groups. Estradiol route did not affect singletons birth weight (β = -30.962, SE = 68.723, p = 0.653), the odds of LGA (Adjusted OR 1.165; 95%CI 0.545, 2.490, p = 0.694), the odds of SGA (Adjusted OR 0.569; 95%CI 0.096, 3.369, p = 0.535) or the preterm delivery (Adjusted OR 0.969; 95%CI 0.292, 3.214, p = 0.959). Conclusion: Estrogen taken orally and vaginally together did not change live birth rate and singleton neonatal outcomes compared to estrogen taken orally, but was accompanied with relative higher serum E2 level and potential maternal undesirable risks.
Use of Fluoride Dentifrices for Children: Evaluation of General and Pediatric Dentists' Recommendations
Authors: Liévana Fernanda Souza , Moreno Ana Paula Dias , Vilela Marina Moscardini , Ferreira José Tarcísio Lima , Saraiva Maria da Conceição Pereira , Rossi Andiara De 
Published: October 2020

Abstract
Background: The aim of this study was to evaluate whether the recommendations of General Dentists (GD) and Pediatric Dentists (PD) on the use of fluoride dentifrice by children are in agreement with the recommendations given in dental association guidelines. Methods: A questionnaire with 11 questions was applied to GD and PD. Questions were about professional performance, as well as type and amount of dentifrices recommended according to the child's age. The way information was conveyed to patients and caregivers was also evaluated. The analysis of the associations between responses and professional training were performed using the Chi-square or Fisher's Exact tests. Results: 354 professionals filled out the questionnaire. The final response rates were 68% for GD and 85% for PD. GD had more recommendations that differ from those found in the guidelines than PD. Conclusion: There is still divergence between the guidelines recommended by dental associations with those of GD and PD. Therefore, it is necessary to conduct educational campaigns for all professionals in the oral health area.
Profiling Non-Coding RNA Levels With Clinical Classifiers in Pediatric Crohn’s Disease
Authors: Pelia Ranjit S. , Venkateswaran Suresh , Matthews Jason D. , Haberman Yael , Cutler David J. , Hyams Jeffrey S. , Denson Lee A. , Kugathasan Subra 
Published: October 2020

Abstract
Background: Crohn’s disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having a substantial impact on biological processes. We investigated whether non-coding RNAs (ncRNA) at diagnosis are dysregulated during CD at different CD locations and future disease behaviors to determine if ncRNA signatures can serve as an index to outcomes. Methods: Using subjects belonging to the RISK cohort, we analyzed ncRNA from the ileal biopsies of 345 CD and 71 non-IBD controls, and ncRNA from rectal biopsies of 329 CD and 61 non-IBD controls. Sequence alignment was done (STAR package) using Human Genome version 38 (hg38) as reference panel. The differential expression (DE) analysis was performed with EdgeR package and DE ncRNAs were identified with a threshold of fold change (FC) >2 and FDR < 0.05 after multiple test corrections. Results: In total, we identified 130 CD specific DE ncRNAs (89 in ileum and 41 in rectum) when compared to non-IBD controls. Similarly, 35 DE ncRNAs were identified between B1 and B2 in ileum, whereas no differences among CD disease behaviors were noticed in rectum. We also found inflammation specific ncRNAs between inflamed and non-inflamed groups in ileal biopsies. Overall, we observed that expression of mir1244-2, mir1244-3, mir1244-4, and RN7SL2 were increased during CD, regardless of disease behavior, location, or inflammatory status. Lastly, we tested ncRNA expression at baseline as potential tool to predict the disease status, disease behaviors and disease inflammation at 3-year follow up.Conclusions: We have identified ncRNAs that are specific to disease location, disease behavior, and disease inflammation in CD. Both ileal and rectal specific ncRNA are changing over the course of CD, specifically during the disease progression in the intestinal mucosa. Collectively, our findings show changes in ncRNA during CD and may have a clinical utility in early identification and characterization of disease progression.
Downregulation of circ-YES1 Suppresses NSCLC Migration and Proliferation Through The miR-142-3p–HMGB1 Axis
Authors: Chi Yongbin , Wang Yan , Zhou Dawei , Liu Wanchao , Han Ruodong , Jin Mingming 
Published: October 2020

Abstract
Background: Circular RNAs (circRNAs) are a new family of abundant regulatory RNAs with roles in various types of cancer. While the hsa_circ_0046701 (circ-YES1) function in non-small cell lung cancer (NSCLC) is unclear. Methods: Circ-YES1 expression in normal pulmonary epithelial and NSCLC cells was examined. The small interfering RNA for circ-YES1 was prepared, cell proliferation and migration were assessed. Tumorigenesis in nude mice was assayed to validate the role of circ-YES1. Bioinformatics analyses and luciferase reporter assays were utilized to identify downstream targets of circ-YES1. Results: Compared to normal pulmonary epithelial cells, the circ-YES1 expression increased in NSCLC cells, and cell proliferation and migration were suppressed after circ-YES1 knockdown. Both high mobility group protein B1 (HMGB1) and miR-142-3p were found to be downstream targets of circ-YES1, and miR-142-3p inhibition and HMGB1 overexpression reversed the effects of circ-YES1 knockdown on cell proliferation and migration. Similarly, HMGB1 overexpression reversed the miR-142-3p overexpression effects on these two processes. The imaging experiment results revealed that circ-YES1 knockdown impeded tumor development and metastasis in a nude mouse xenograft model. Conclusion: Taken together, our results show that circ-YES1 promotes tumor development through the miR-142-3p–HMGB1 axis and support the development of circ-YES1 as a new therapeutic NSCLC target.
The Value of The Accessory Pathway Potential in Guiding The Electrode Selection for Ablation Within Coronary Sinus
Authors: Sun XiaoLin , Jiang Jiang , Xu Pei , Jin Kai , Bao ZhengYu 
Published: October 2020

Abstract
Background: The ablation of the coronary sinus (CS) is becoming more and more important in accessory pathway-related supraventricular tachycardia ablation. In comparison with temperature-controlled catheters (TCC), irrigated-tip catheter (ITC) are more expensive and cause more damage in accessory pathway-related supraventricular tachycardia ablation. We intended to develop a new method for the reasonable selection of electrode for coronary sinus(CS) ablation via assessing the relationship between the accessory pathway (AP) potential and time of successful ablation. Methods：Among the patients who had detected the bypass potential during radiofrequency ablation between 1/1/2015 and 12/31/2019. TCC was performed in 330 patients receiving endocardial ablation. 30 patients underwent radiofrequency catheter ablation (RFCA) in CS. The relationship between AP potential and time of successful ablation was analyzed. Results：330 cases of TCC ablation within the endocardium revealed that the amplitude of AP potential was significantly and negatively correlated with the time of successful ablation (r = -0.79, p < 0.001). In CS ablation, the median baseline amplitude of the AP potentials in patients with successful TCC ablation was higher than that in patients with ITC following TCC ablation failure (p = 0.02). The optimal cutoff value of the amplitude of the AP potential to guide the selection of a catheter for ablation was 1.07 mV, and the sensitivity and specificity were 80% and 90%, respectively. Conclusion：The AP potential is helpful for the electrode selection in CS ablation.
Prevalence of Scabies and Its Associated Factors Among School-Age Children in Arba Minch Zuria District, Southern Ethiopia, 2018.
Authors: Girma Eyayou , Churko Chuchu , Alagaw Amsalu , Haftu Desta , Tunje Abayneh , Tsegaye Behailu 
Published: October 2020

Abstract
Background: Scabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have a considerable impact on general health leading to illness and death not only through the direct effect of its infestation and as a result of secondary bacterial infection. This study aimed to assess the prevalence of scabies and its associated factors among school-age children in Arba Minch Zuria district, Gamo zone, Southern Ethiopia.Methods: A community-based cross-sectional study was carried out in 825 school-age children from February 20 to March 30, 2018. A multi-stage sampling technique was used to select study populations. Logistic regression analysis was used to identify factors associated with scabies. Findings were presented using 95% CI of Crude Odds Ratios (COR) and Adjusted Odds Ratios (AOR). To declare statistical significance, a p-value of less than 0.05 was used. Result: A total of 825 children participated in the study with a response rate of 97.6%. The overall prevalence of scabies was 16.4% [95% CI: 13.9%, 18.9%]. Overcrowding index, family history of itching in the past two weeks, wealth index, knowledge of scabies, climatic zone (living in the highland area), frequency of washing body, frequency of washing clothes, fingernails cutting practice, history of skin contact with scabies patient, washing hair more than once weekly, and sharing of clothes were significantly associated scabies disease.Conclusion: In conclusion, the prevalence of scabies in Arba Minch lies at 16.4% in the global scabies range from 0.2% to 71.4%. The prevalence was highest in highlands followed by midland and then lowland. This represents a significant scabies burden which we recommend warrants health service intervention.
Ultrarobust, tough and highly stretchable self-healing materials based on cartilage-inspired noncovalent assembly nanostructure
Authors: Wang Yuyan , Huang Xin , Zhang Xinxing 
Published: October 2020

Abstract
Self-healing materials integrated with robust mechanical strength and high healing efficiency simultaneously would be of great use in many fields but have been proven to be extremely challenging. Here, inspired by animal cartilage, we present a ultrarobust self-healing material by incorporating high density noncovalent bonds at interface between the assembled interwoven network of two-dimensional nanosheets and polymer matrix to collectively produce a strong interfacial interaction. The resulted nanocomposite material shows robust tensile strength (52.3 MPa), high toughness (282.7 MJ m–3, which is 1.6 times higher than spider silk and 9.4 times higher than metallic aluminum), high stretchability (1020.8%) and excellent healing efficiency (80-100%), which overturns previous understanding of the traditional noncovalent bonding self-healing materials that high mechanical robustness and healing ability tend to be mutually exclusive. Moreover, the interfacical supramolecular crosslinking structure enables the functional-healing ability of the resultant flexible devices. This work opens an avenue toward the development of ultrarobust self-healing materials for various flexible functional devices.
Strengthening Health Systems in Humanitarian Settings: Multi-Stakeholder Insights on Contraception and Postabortion Care Programs in the Democratic Republic of Congo and Somalia
Authors: Tran Nguyen Toan , Meyers Janet , Malilo Bibiche , Chabo Julien , MUSELEMU Jean-Baptiste , RIZIKI Bienvenu , LIBONGA Patrick , SHIRE Abdikani , HAD Hussein , ALI Mohamed , ARAB Mohamed Abdi , DA’AR Jama Mohamed , KAHOW Mohamed Hussein , ADIVE Joseph Ege , GEBRU Binyam , MONAGHAN Emily , MORRIS Catherine N , GALLAGHER Meghan , JOUANICOT Virginie , POUGNIER Natacha , AMSALU Ribka 
Published: October 2020

Abstract
BackgroundIn humanitarian settings, strengthening health systems while responding to the health needs of crisis-affected populations is challenging and marked with evidence gaps. Drawing from a decade of family planning and postabortion care programming in humanitarian settings, this paper aims to identify strategic components that contribute to health system strengthening in such contexts. MethodsA diverse range of key informants from North Kivu (Democratic Republic of Congo, DRC) and Puntland (Somalia), including female and male community members, adolescents and adults, healthcare providers, government and community leaders, participated in qualitative interviews, which applied the World Health Organization health system building blocks framework. Data were thematically analyzed according to this framework.ResultsFindings from the focus group discussions (11 in DRC, 7 in Somalia) and key informant interviews (7 in DRC, 4 in Somalia) involving in total 54 female and 72 male participants across both countries indicate that health programs in humanitarian settings, such as Save the Children’s initiative on family planning and postabortion care, could contribute to strengthening health systems by positively influencing national policies and guidance, strengthening local coordination mechanisms, capacitating the healthcare workforce with competency-based training and supportive supervision (benefiting facilities supported by the project and beyond), developing the capacity of Ministry of Health staff in the effective management of the supply chain, actively and creatively mobilizing the community to raise awareness and create demand, and providing quality and affordable services. Financial sustainability is challenged by the chronically limited healthcare expenditure experienced in both humanitarian contexts.ConclusionsIn humanitarian settings, carefully designed healthcare interventions, such as those that address the family planning and postabortion care needs of crisis-affected populations, are able not only to increase access to essential services but also contribute to strengthening several components of the health system while increasing the government capacity, ownership, and accountability.