bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiloop edgewise archwire technique and denture frame analysis: a systematic review
Authors: Tabancis M. , Ratzmann A. , Doberschütz P. , Krey K. F. 
Published: November 2020

AbstractBackgroundThe Multiloop Edgewise Archwire (MEAW) appliance is an orthodontic treatment method suitable for the therapy of severe types of malocclusions such as open bites or anterior crossbites. The cephalometric Denture Frame Analysis (DFA) provides a supportive diagnostic tool for patient-specific treatment planning concerning the rearrangement of occlusion within the “denture frame”. The objective of this study is to give a comprehensive overview of the national and international scientific literature about MEAW and DFA regarding the general therapeutic effects, advantages and limitations.Methods and materialsA computerized literature search was performed using four principal medical databases (PubMed/Medline, Google Scholar, Web of Science and Cochrane Central Register of Controlled Trials) and supplemented by manual searching of the references listed in the retrieved articles. The results were screened and assessed following the PRISMA guidelines.ResultsSix hundred seventy-seven full articles were assessed for eligibility. A number of 134 articles went through qualitative analysis and 3 studies were finally involved in comparative synopsis. The findings reveal advantageous characteristics of the MEAW technique such as a high degree of three-dimensional individual tooth control and a comparatively low load deflection rate, causing mostly dentoalveolar changes without significantly influencing the skeletal structures.ConclusionBased on current literature, the MEAW technique appears to have several therapeutic benefits and serves as a sufficient alternative treatment method for dentoalveolar compensation, when measures of orthognathic surgery are rejected. Concerning the deficient data basis of available literature and the low level of scientific evidence, further studies are required in order to expand on the knowledge in this subject area. Several aspects like the effectiveness or the long-term stability have to be evaluated more extensively. Moreover, the transferability of the DFA to ethnic groups other than the Asian ethnicity should be examined further.
High output cardiac failure in 3 patients with hereditary hemorrhagic telangiectasia and hepatic vascular malformations, evaluation of treatment
Authors: Olsen Lilian B. , Kjeldsen Anette D. , Poulsen Mikael K. , Kjeldsen Jens , Fialla Annette D. 
Published: November 2020

AbstractBackgroundThis report addresses how patients with hereditary hemorrhagic telangiectasia (HHT) and high output cardiac failure (HOCF) due to hepatic vascular malformations, should be evaluated and could be treated. HHT is a genetic disorder, leading to vascular abnormalities with potentially serious clinical implications. In the liver, arteriovenous malformations occur in more than 70% of patients, but only about 8% present clinical symptoms such as HOCF with pulmonary hypertension and less commonly portal hypertension, biliary ischemia and hepatic encephalopathy.ResultsThree female patients with HHT type 2 and HOCF caused by severe arteriovenous malformations in the liver are presented in this case series. The patients were seen at the HHT-Centre at Odense University Hospital. Treatment with either orthotopic liver transplantation (one patient) or bevacizumab (two patients) was initiated. All patients experienced marked symptom relief and objective improvement. New York Heart Association—class were improved, ascites, peripheral edema and hence diuretic treatment was markedly reduced or discontinued in all three patients. Bevacizumab also resulted in notable effects on epistaxis and anemia.ConclusionOur findings substantiate the importance of identification of symptomatic arteriovenous malformations in the liver in patients with HHT. Bevacizumab may possibly, as suggested in this case series and supported by previous case studies, postpone the time to orthotopic liver transplantation or even make it unnecessary. Bevacizumab represents a promising new treatment option, which should be investigated further in clinical trials.
The genetic landscape of crystallins in congenital cataract
Authors: Berry Vanita , Ionides Alex , Pontikos Nikolas , Georgiou Michalis , Yu Jing , Ocaka Louise A. , Moore Anthony T. , Quinlan Roy A. , Michaelides Michel 
Published: November 2020

Abstract
Background
The crystalline lens is mainly composed of a large family of soluble proteins called the crystallins, which are responsible for its development, growth, transparency and refractive index. Disease-causing sequence variants in the crystallins are responsible for nearly 50% of all non-syndromic inherited congenital cataracts, as well as causing cataract associated with other diseases, including myopathies. To date, more than 300 crystallin sequence variants causing cataract have been identified.

Methods
Here we aimed to identify the genetic basis of disease in five multi-generation British families and five sporadic cases with autosomal dominant congenital cataract using whole exome sequencing, with identified variants validated using Sanger sequencing. Following bioinformatics analysis, rare or novel variants with a moderate to damaging pathogenicity score, were filtered out and tested for segregation within the families.

Results
We have identified 10 different heterozygous crystallin variants. Five recurrent variants were found: family-A, with a missense variant (c.145C>T; p.R49C) in CRYAA associated with nuclear cataract; family-B, with a deletion in CRYBA1 (c.272delGAG; p.G91del) associated with nuclear cataract; and family-C, with a truncating variant in CRYGD (c.470G>A; W157*) causing a lamellar phenotype; individuals I and J had variants in CRYGC (c.13A>C; T5P) and in CRYGD (c.418C>T; R140*) causing unspecified congenital cataract and nuclear cataract, respectively. Five novel disease-causing variants were also identified: family D harboured a variant in CRYGC (c.179delG; R60Qfs*) responsible for a nuclear phenotype; family E, harboured a variant in CRYBB1 (c.656G>A; W219*) associated with lamellar cataract; individual F had a variant in CRYGD (c.392G>A; W131*) associated with nuclear cataract; and individuals G and H had variants in CRYAA (c.454delGCC; A152del) and in CRYBB1 (c.618C>A; Y206*) respectively, associated with unspecified congenital cataract. All novel variants were predicted to be pathogenic and to be moderately or highly damaging.

Conclusions
We report five novel variants and five known variants. Some are rare variants that have been reported previously in small ethnic groups but here we extend this to the wider population and record a broader phenotypic spectrum for these variants.
Investigation of bovine ephemeral fever virus transmission by putative dipteran vectors under experimental conditions
Authors: Stokes Jessica E. , Darpel Karin E. , Gubbins Simon , Carpenter Simon , Fernández de Marco María del Mar , Hernández-Triana Luis M. , Fooks Anthony R. , Johnson Nicholas , Sanders Christopher 
Published: November 2020

Abstract
Background
Bovine ephemeral fever virus (Rhabdoviridae: Ephemerovirus) (BEFV) causes bovine ephemeral fever (BEF), an economically important disease of cattle and water buffalo. Outbreaks of BEF in Africa, Australia, Asia and the Middle East are characterized by high rates of morbidity and highly efficient transmission between cattle hosts. Despite this, the vectors of BEFV remain poorly defined.

Methods
Colony lines of biting midges (Culicoides sonorensis) and mosquitoes (Aedes aegypti, Culex pipiens and Culex quinquefasciatus) were infected with a strain of BEFV originating from Israel by feeding on blood–virus suspensions and by intrathoracic inoculation. In addition, in vivo transmission of BEFV was also assessed by allowing C. sonorensis inoculated by the intrathoracic route to feed on male 6 month-old Holstein-Friesian calves.

Results
There was no evidence of BEFV replication within mosquitoes fed on blood/virus suspensions for mosquitoes of any species tested for each of the three colony lines. In 170 C. sonorensis fed on the blood/virus suspension, BEFV RNA was detected in the bodies of 13 individuals and in the heads of two individuals, indicative of fully disseminated infections and an oral susceptibility rate of 1.2%. BEFV RNA replication was further demonstrated in all C. sonorensis that were inoculated by the intrathoracic route with virus after 5, 6 or 7 days post-infection. Despite this, transmission of BEFV could not be demonstrated when infected C. sonorensis were allowed to feed on calves.

Conclusions
No evidence for infection or dissemination of BEFV (bovine/Israel/2005-6) in mosquitoes of three different species was found. Evidence was found for infection of C. sonorensis by the oral route. However, attempts to transmit BEFV to calves from infected C. sonorensis failed. These results highlight the challenge of defining the natural vector of BEFV and of establishing an in vivo transmission model. The results are discussed with reference to the translation of laboratory-based studies to inference of vector competence in the field.

Graphical abstract
Informant-based screening tools for diagnosis of dementia, an overview of systematic reviews of test accuracy studies protocol
Authors: Taylor-Rowan Martin , Nafisi Sara , Patel Amit , Burton Jennifer K. , Quinn Terry J. 
Published: November 2020

Abstract
Background
Robust diagnosis of dementia requires an understanding of the accuracy of the available diagnostic tests. Informant questionnaires are frequently used to assess for dementia in clinical practice. Recent systematic reviews have sought to establish the diagnostic test accuracy of various dementia informant screening tools. However, most reviews to date have focused on a single diagnostic tool and this does not address which tool is ‘best’. A key aim of the overview of systematic reviews is to present a disparate evidence base in a single, easy to access platform.

Methods
We will conduct an overview of systematic reviews in which we ‘review the systematic reviews’ of diagnostic test accuracy studies evaluating informant questionnaires for dementia. As an overview of systematic reviews of test accuracy is a relatively novel approach, we will use this review to explore methods for visual representation of complex data, for highlighting evidence gaps and for indirect comparative analyses. We will create a list of informant tools by consulting with dementia experts. We will search 6 databases (EMBASE (OVID); Health and Psychosocial Instruments (OVID); Medline (OVID); CINAHL (EBSCO); PSYCHinfo (EBSCO) and the PROSPERO registry of review protocols) to identify systematic reviews that describe the diagnostic test accuracy of informant questionnaires for dementia. We will assess review quality using the AMSTAR-2 (Assessment of Multiple Systematic Reviews) and assess reporting quality using PRISMA-DTA (Preferred Reporting Items for Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies) checklists. We will collate the identified reviews to create an ‘evidence map’ that highlights where evidence does and does not exist in relation to informant questionnaires. We will pool sensitivity and specificity data via meta-analysis to generate a diagnostic test accuracy summary statistic for each informant questionnaire. If data allow, we will perform a statistical comparison of the diagnostic test accuracy of each informant questionnaire using a network approach.

Discussion
Our overview of systematic reviews will provide a concise summary of the diagnostic test accuracy of informant tools and highlight areas where evidence is currently lacking in this regard. It will also apply network meta-analysis techniques to a new area.
A guide for pre-procedural imaging for transcatheter aortic valve replacement patients
Authors: Perry Tjörvi E. , George Stephen A. , Lee Belinda , Wahr Joyce , Randle Darrell , Sigurðsson Garðar 
Published: November 2020

AbstractSafe and accurate pre-procedural assessment of cardiovascular anatomy, physiology, and pathophysiology prior to TAVR procedures can mean the difference between success and catastrophic failure. It is imperative that clinical care team members share a basic understanding of the preprocedural imaging technologies available for optimizing the care of TAVR patients. Herein, we review current imaging technology for assessing the anatomy, physiology, and pathophysiology of the aortic valvular complex, ventricular function, and peripheral vasculature, including echocardiography, cardiac catheterization, cardiac computed tomography, and cardiac magnetic resonance prior to a TAVR procedure. The authorship includes cardiac-trained anesthesiologists, anesthesiologists with expertise in pre-procedural cardiac assessment and optimization, and interventional cardiologists with expertise in cardiovascular imaging prior to TAVRs. Improving the understanding of all team members will undoubtedly translate into safer, more coordinated patient care.
Flight delay prediction based on deep learning and Levenberg-Marquart algorithm
Authors: Yazdi Maryam Farshchian , Kamel Seyed Reza , Chabok Seyyed Javad Mahdavi , Kheirabadi Maryam 
Published: November 2020

AbstractFlight delay is inevitable and it plays an important role in both profits and loss of the airlines. An accurate estimation of flight delay is critical for airlines because the results can be applied to increase customer satisfaction and incomes of airline agencies. There have been many researches on modeling and predicting flight delays, where most of them have been trying to predict the delay through extracting important characteristics and most related features. However, most of the proposed methods are not accurate enough because of massive volume data, dependencies and extreme number of parameters. This paper proposes a model for predicting flight delay based on Deep Learning (DL). DL is one of the newest methods employed in solving problems with high level of complexity and massive amount of data. Moreover, DL is capable to automatically extract the important features from data. Furthermore, due to the fact that most of flight delay data are noisy, a technique based on stack denoising autoencoder is designed and added to the proposed model. Also, Levenberg-Marquart algorithm is applied to find weight and bias proper values, and finally the output has been optimized to produce high accurate results. In order to study effect of stack denoising autoencoder and LM algorithm on the model structure, two other structures are also designed. First structure is based on autoencoder and LM algorithm (SAE-LM), and the second structure is based on denoising autoencoder only (SDA). To investigate the three models, we apply the proposed model on U.S flight dataset that it is imbalanced dataset. In order to create balance dataset, undersampling method are used. We measured precision, accuracy, sensitivity, recall and F-measure of the three models on two cases. Accuracy of the proposed prediction model analyzed and compared to previous prediction method. results of three models on both imbalanced and balanced datasets shows that precision, accuracy, sensitivity, recall and F-measure of SDA-LM model with imbalanced and balanced dataset is improvement than SAE-LM and SDA models. The results also show that accuracy of the proposed model in forecasting flight delay on imbalanced and balanced dataset respectively has greater than previous model called RNN.
Relative validity of a brief dietary survey to assess food intake and adherence to national dietary guidelines among Sri Lankan adults
Authors: Renzella J. , Fernando S. , Kalupahana B. , Townsend N. , Rayner M. , Wickramasinghe K. , Katulanda P. , Scarborough P. 
Published: November 2020

AbstractBackgroundSuboptimal diet is the leading cause of global morbidity and mortality. Addressing this problem requires context-specific solutions informed by context-specific data collected by context-specific tools. This study aimed to assess the relative validity of a newly developed brief dietary survey to estimate food intake and adherence to the Food Based Dietary Guidelines for Sri Lankans.MethodsBetween December 2018 and February 2019, we interviewed 94 Sri Lankan adults living in Colombo (Western Province), Kalutara (Western Province), and Trincomalee (Eastern Province). We assessed the relative validity of the Sri Lankan Brief Dietary Survey (SLBDS) with Wilcoxon rank-sum tests, Spearman’s Rho correlation coefficients, Bland–Altman plots, and Cohen’s kappa tests using a 24-h Dietary Recall (24DR) as reference.ResultsNinety-four adults (40.7 years ±12.6; 66% female) completed both surveys during the same interview. With the exception of ‘Fish, pulses, meat and eggs’ food group median intake, which was underestimated by the SLBDS compared to the 24DR, there was no strong evidence of difference between median intakes reported by the two methods. Correlation coefficients were highest for ‘Milk and dairy products’ (0.84) at the food group level and for ‘dosa’, ‘hoppers’, ‘milk rice’, and ‘dried fish’ (1.00) among individual food and beverages. Visual exploration of Bland-Altman plots showed acceptable agreement between the SLBDS and 24DR, with the SLBDS tending to overestimate consumption as the number of servings of ‘Rice, bread, other cereals and yams’ and ‘Vegetables’ consumed increased and slightly underestimate consumption as the number of servings of ‘Fish, pulses, meat and eggs’, ‘Milk and dairy products’, and ‘Nuts’ increased. Kappa values ranged from from 0.59 (95% CI: 0.32–0.86) for ‘Vegetables’ to 0.81 (95% CI: 0.66–0.96) for ‘Fruit’ indicating a moderate to strong level of agreement.ConclusionsHaving been developed for and relatively validated with the study population in question, our study shows that the SLBDS can be used as a fit for purpose research tool. Additional research is needed to assess SLBDS test-retest reliability and to validate further the reporting of salt, oil, and coconut intake.
Atypical benzodiazepine misuse and withdrawal in patient with epilepsy: a case report
Authors: Piskorska Natalia , Silczuk Andrzej 
Published: November 2020

Abstract
Background
Benzodiazepines (BDZ) are a class of psychoactive drugs that have been widely used for the treatment of many medical conditions. In this paper, a case of an atypical pattern of diazepam dependence in a patient with epilepsy is presented. The article may be an interesting proposition for rational management in the treatment of benzodiazepine dependence in a patient with non-withdrawal and withdrawal seizures. Detoxification is used then to optimize neurological treatment.

Case presentation
A 52-year-old Caucasian male, diagnosed with epilepsy with partial complex, and rarely tonic-clonic seizures and benzodiazepine (diazepam) misuse, was admitted to a detoxification unit specialized to treat substance dependence. This patient presented an atypical schedule of substance misuse with a weekly dose of 40 to 45 mg of diazepam, taken once a week, every Saturday. The patient reported having a group of symptoms that usually preceded generalized seizures that were described as the “aura” manifesting as confusion, derealisation, anxiety, and difficulties in speaking. First Saturday after admission to the hospital, the first aura experience was reported, while diazepam level in serum was higher than usual, which was supporting also strong psychological background for withdrawal. On weekend days, 3 weeks after admission, when the patient was receiving 3 mg of diazepam daily, he developed a severe “aura.” The EEG showed no seizure activity. Two weeks later (again Friday to Saturday), the patient reported the occurrence of aura, the EEG recording showed paroxysmal discharges, generalized multiple spikes associated with slow waves, lasting about 30 s, accompanied by eyelid myoclonia and disturbed consciousness. A week later another aura developed that resolved spontaneously without a seizure. Twelve days later, diazepam was completely removed; the elimination of serum benzodiazepines took place. The patient did not report aura until the end of the stay and he was dismissed 5 weeks later.

Conclusions
The differential diagnosis of an aura can be challenging. Carefully proceed serum monitored elimination of benzodiazepines in epileptic patients may serve in safety benefits and helps to achieve detoxification goals. Hence, it is important to prevent, recognize, and treat benzodiazepine dependence in every patient and may improve epilepsy treatment outcome.
Large-eddy simulation of wall-bounded turbulent flow with high-order discrete unified gas-kinetic scheme
Authors: Zhang Rui , Zhong Chengwen , Liu Sha , Zhuo Congshan 
Published: November 2020

AbstractIn this paper, we introduce the discrete Maxwellian equilibrium distribution function for incompressible flow and force term into the two-stage third-order Discrete Unified Gas-Kinetic Scheme (DUGKS) for simulating low-speed turbulent flows. The Wall-Adapting Local Eddy-viscosity (WALE) and Vreman sub-grid models for Large-Eddy Simulations (LES) of turbulent flows are coupled within the present framework. Meanwhile, the implicit LES are also presented to verify the effect of LES models. A parallel implementation strategy for the present framework is developed, and three canonical wall-bounded turbulent flow cases are investigated, including the fully developed turbulent channel flow at a friction Reynolds number (Re) about 180, the turbulent plane Couette flow at a friction Re number about 93 and lid-driven cubical cavity flow at a Re number of 12000. The turbulence statistics, including mean velocity, the r.m.s. fluctuations velocity, Reynolds stress, etc. are computed by the present approach. Their predictions match precisely with each other, and they are both in reasonable agreement with the benchmark data of DNS. Especially, the predicted flow physics of three-dimensional lid-driven cavity flow are consistent with the description from abundant literature. The present numerical results verify that the present two-stage third-order DUGKS-based LES method is capable for simulating inhomogeneous wall-bounded turbulent flows and getting reliable results with relatively coarse grids.
High order semi-implicit weighted compact nonlinear scheme for the all-Mach isentropic Euler system
Authors: Jiang Yanqun , Chen Xun , Zhang Xu , Xiong Tao , Zhou Shuguang 
Published: November 2020

AbstractThe computation of compressible flows at all Mach numbers is a very challenging problem. An efficient numerical method for solving this problem needs to have shock-capturing capability in the high Mach number regime, while it can deal with stiffness and accuracy in the low Mach number regime. This paper designs a high order semi-implicit weighted compact nonlinear scheme (WCNS) for the all-Mach isentropic Euler system of compressible gas dynamics. To avoid severe Courant-Friedrichs-Levy (CFL) restrictions for low Mach flows, the nonlinear fluxes in the Euler equations are split into stiff and non-stiff components. A third-order implicit-explicit (IMEX) method is used for the time discretization of the split components and a fifth-order WCNS is used for the spatial discretization of flux derivatives. The high order IMEX method is asymptotic preserving and asymptotically accurate in the zero Mach number limit. One- and two-dimensional numerical examples in both compressible and incompressible regimes are given to demonstrate the advantages of the designed IMEX WCNS.