bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mujer, Gobierno Corporativo y eficiencia económica: análisis para el caso de las empresas familiares agroalimentarias
Authors: Nájera-Vázquez Cinthia , Martínez-Romero María J. 
Published: July 2020

En la actualidad, el estudio de la diversidad de género en el ámbito empresarial está alcanzando una relevancia considerable, debido a la incorporación de la mujer a la vida laboral. Las Empresas Familiares han sido claves para la incorporación de las mujeres al mercado de trabajo, debido, entre otros motivos a la existencia de roles compartidos y al solapamiento de valores familiares y empresariales. La mayor parte de los estudios existentes sobre temas de género se centran en el efecto de la presencia femenina sobre distintas medidas de rendimiento, pero los resultados no son concluyentes en absoluto. Para ahondar en estas cuestiones, el presente trabajo analiza cómo influye la participación femenina en tres órganos de gobierno corporativo: Consejo de Administración, Junta General de Accionistas y Equipo Directivo, sobre la eficiencia económica de las Empresas Familiares Agroalimentarias. Los resultados obtenidos de una muestra de 147 Empresas Familiares Agroalimentarias Españolas, ponen de manifiesto que, la presencia femenina en los Consejos de Administración y en la Junta General de Accionistas, ejerce un impacto positivo y significativo en la eficiencia económica.
La presencia de las cooperativas de Catalunya en Internet
Authors: Araujo Batlle Alex , Serrano Robles Eloi , Jordan Vallverdú Victor 
Published: July 2020

Internet se ha convertido en la electricidad del siglo XXI. La presencia en la red es un imperativo para cualquier empresa que quiera ser encontrada. Además, factores como la consolidación del uso de dispositivos móviles como ventanas para acceder a la red y los hábitos de las generaciones que se incorporan al mercado, refuerzan la necesidad de considerar la presencia en la red para cualquier empresa, incluidas las cooperativas. El presente trabajo analiza la presencia web de 3860 cooperativas de Catalunya a través la combinación de técnicas cuantitativas y cualitativas. Los resultados apuntan que dos de cada tres cooperativas no disponen de una página web propia, siendo la falta de recursos, de formación y el poco soporte institucional las principales causas de estos datos. El presente trabajo pretende ser una herramienta para conocer el estado actual de las cooperativas en internet y una aproximación para enfocar las estrategias de futuro.
Measurement properties of the Knee Injury and Osteoarthritis Outcome Score Patello-Femoral questionnaire in Saudi Arabians
Authors: Ateef Mahamed 
Published: July 2020

Background
No Arabic or its dialect questionnaire is available to evaluate the anterior knee pain in the Saudi Arabian religious population. This study aims to translate, adapt, and psychometrically validate the Knee Injury and Osteoarthritis Outcome Score (KOOS-PF) Patellofemoral scale in the Arabic language in Saudi Arabic dialect.

Method
Translation has been done as per standard guidelines. The questionnaire was administered to 95 patients to determine the psychometric properties including on two different occasions, with a 48-hour gap in-between; to ensure that their answers were reliable; 84 patients (88.4% compliance rate) responded for test and retest reliability, ceiling-floor effects, validity and other psychometric criteria.

Results
Cronbach’s alpha (internal consistency) and test–retest reliability was good and excellent (∞ = 0.81; ICC > 0.95). None of the items showed >30% floor or ceiling effect and the minimal detectable change was within the acceptable range (<30%). The KOOS-PF subscale showed a moderate correlation (−0.568) with pain-visual analog scale for its construct validity.

Conclusion
The Arabic dialect of KOOS-PFis reliable and valid to be used to evaluate isolated knee pain of patellofemoral origin in Muslim patients in Saudi Arabia.
Identification of Maize Downy Mildew Pathogen in Lampung and the Effects of Varieties and Metalaxyl on Disease Incidence
Authors: Ginting Cipta , Prasetyo Joko , Dirmawati Suskandini Ratih , Ivayani . , Timotiwu Paul Benyamin , Maryono Tri , Widyastuti . , Chafisa Damar Indah Ryska , Asyifa Alim , Setyowati Erisa , Pasaribu Ambos Harry Zuisent 
Published: July 2020

Introduction: Maize downy mildew (MDM) is considered as a major problem in all maize growing areas in Indonesia including the Province of Lampung.
Objectives: The objectives of this study were (i) to identify the species of Peronosclerospora causing maize downy mildew (MDM) in Lampung, (ii) to determine the influence of varieties on the intensity of downy mildew and (iii) to determine the efficacy of metalaxyl to control MDM on some maize varieties.
Methodology: To identify Peronosclerospora causing MDM, the pathogens were observed under light microscope and scanning electron microscope. Maize varieties response against pathogens and efficacy metalaxyl were studied in the field with the test plants exposed to plants showing MDM symptoms as the sources of inocula to mimic natural conditions.
Results: Peronosclerospora sorghi, P. maydis, and P. philippinensis were found to cause MDM in Lampung. On both varieties Pioneer 27 (P-27) and NK-22, AUDPC on F1 plants was greater than that on F2 plants. On P-27, the production of F2 was higher than that of F1 plants, but there was not significant difference in production between F1 and F2 of NK-22 variety. Seed treatment using metalaxyl was not effective to control downy mildew of maize.
Conclusion: Three species of Peronosclerospora were identified as disease-causing pathogen of MDM in Lampung, but these results were tentatively pending for further studies through molecular techniques. F1 plants were more susceptible than F2 plants to MDM in both P-27 and NK-22. Metalaxyl was not effective in controlling MDM.
Prevalence and Determinants of Depression among Caregivers of Children with Heart Diseases in Nigeria
Authors: Chikezie Eze U. , Duru Chika O. , Okpokowuruk Frances S. 
Published: July 2020

Context: Caregivers of children with heart diseases are faced with the long term care of these children and may suffer psychological illnesses as a result.
Aims: To determine the prevalence and determinants of depression among caregivers of children with heart diseases attending two Out-patient clinics in South-South Nigeria.
Materials and Methods: It was a cross-sectional study involving the use of the revised Center for Epidemiological Studies Depression (CESD-R) questionnaire. Data were entered into an Excel spreadsheet and analyzed using SPSS 22.0.
Results: Ages of the participants ranged from 24 to 59 years with a mean age of 37.49 years (SD 6.973) and majority were female (79.9%). The overall mean CESD-R score was 8.61 (SD 16.18), ranging from 0 to 60. There was a significant difference in the CESD-R scores between male and female participants (t=2.362, p=0.02) with females scoring higher than males (10.24± 17.69 and 2.15± 3.13) respectively. Overall, depression was found among 23(17.1%) participants. Depression was significantly associated with the female sex (x2=7.006, p=0.009), a history of a mental health illness in the past (x2=66.496, p=0.029) and the marital status of the participants (x2=19.776, p=0.05). No significant relationship was found between depression and age, religion, tribe and educational status (p>0.05), history of medical illnesses (x2=53.006, p=0.538) or type of heart disease the children/wards of the participants were being managed for (x2=8.274, p=0.902).
Conclusion: The rate of depression among caregivers of children being managed for congenital and acquired heart diseases in this study is significant. It is recommended that caregivers of children with congenital and acquired heart diseases are routinely given relevant psychosocial support to prevent the development of depression. Routine screening for depression and appropriate intervention for those who meet the criteria is also recommended.
Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine
Authors: Kim Se‐jeong , Kim Eun Mi , Yamamoto Masaya , Park Hansoo , Shin Heungsoo 
Published: July 2020

AbstractMulti‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular matrix interactions, and thus, have been widely utilized as implantable therapeutics and various ex vivo tissue models in tissue engineering. In principle, spheroid culture methods maximize cell–cell cohesion and induce spontaneous cellular assembly while minimizing cellular interactions with substrates by using physical forces such as gravitational or centrifugal forces, protein‐repellant biomaterials, and micro‐structured surfaces. In addition, biofunctional materials including magnetic nanoparticles, polymer microspheres, and nanofiber particles are combined with cells to harvest composite spheroids, to accelerate spheroid formation, to increase the mechanical properties and viability of spheroids, and to direct differentiation of stem cells into desirable cell types. Biocompatible hydrogels are developed to produce microgels for the fabrication of size‐controlled spheroids with high efficiency. Recently, spheroids have been further engineered to fabricate structurally and functionally reliable in vitro artificial 3D tissues of the desired shape with enhanced specific biological functions. This paper reviews the overall characteristics of spheroids and general/advanced spheroid culture techniques. Significant roles of functional biomaterials in advanced spheroid engineering with emphasis on the use of spheroids in the reconstruction of artificial 3D tissue for tissue engineering are also thoroughly discussed.
A Carbon Flower Based Flexible Pressure Sensor Made from Large‐Area Coating
Authors: JK O'Neill Stephen , Gong Huaxin , Matsuhisa Naoji , Chen Shucheng , Moon Hanul , Wu Hung‐Chin , Chen Xianfeng , Chen Xiaodong , Bao Zhenan 
Published: July 2020

AbstractFlexible pressure sensors are an essential part of robotic skin for human–machine interfaces, wearables, and implantable biomedical devices. However, the desirable characteristics of high sensitivity, conformability, and good scalability are often mutually exclusive. Here, a highly sensitive and flexible pressure sensor that can be easily fabricated by coating a carbon flower and elastomer composite is presented. The composite made from uniform‐sized carbon flower particles exhibits a contact‐based mechanism for pressure sensing, as opposed to typical carbon black pressure sensitive composites which utilize percolation as the sensing mechanism. The contact mechanism allows for an active layer down to 13 µm, and a bending insensitivity down to a 5.5 mm bending radius, while maintaining a high sensitivity. Furthermore, the composite is printed over a large 1 m × 2 cm pressure sensing area, showing the preparation of this sensor can be scaled to large area.
Predictors of interleukin‐1β and interleukin‐1 receptor antagonist in infant saliva
Authors: Miller Elizabeth M. 
Published: July 2020

AbstractObjectivesThis study assesses the feasibility of measuring interleukin‐1β (IL‐1β) and interleukin‐1 receptor antagonist (IL‐1ra) in infant salivary samples as representative of pro‐ and anti‐inflammatory processes, and explores predictors of these biomarkers in a US population.MethodsData were collected from 73 US mother‐infant pairs. Salivary samples were collected with an infant swab and analyzed for IL‐1β, IL‐1ra, and immunoglobulin A (IgA) using ELISA. Household, maternal, infant, and anthropometric predictors were selected using stepwise regression to build final multivariate models.ResultsBoth IL‐1β and IL‐1ra can be feasibly measured in infant saliva. The predictors in the final IL‐1β model were IL‐1ra and reported infant illness. IL‐1β, IgA, infant age, household income, maternal BMI, and infant weight‐for‐age z‐score were significant in the final model for IL‐1ra.ConclusionsIL‐1β and IL‐ra are useful biomarkers of immune function for infants. In particular, IL‐1ra has the potential to address the relationship between immune function and body composition in the mother‐infant dyad.
Health‐care use and cost for multimorbid persons with dementia in the National Health and Aging Trends Study
Authors: MacNeil‐Vroomen Janet L. , Thompson Mary , Leo‐Summers Linda , Marottoli Richard A. , Tai‐Seale Ming , Allore Heather G. 
Published: July 2020

AbstractBackgroundMost persons with dementia have multiple chronic conditions; however, it is unclear whether co‐existing chronic conditions contribute to health‐care use and cost.MethodsPersons with dementia and ≥2 chronic conditions using the National Health and Aging Trends Study and Medicare claims data, 2011 to 2014.ResultsChronic kidney disease and ischemic heart disease were significantly associated with increased adjusted risk ratios of annual hospitalizations, hospitalization costs, and direct medical costs. Depression, hypertension, and stroke or transient ischemic attack were associated with direct medical and societal costs, while atrial fibrillation was associated with increased hospital and direct medical costs. No chronic condition was associated with informal care costs.ConclusionsAmong older adults with dementia, proactive and ambulatory care that includes informal caregivers along with primary and specialty providers, may offer promise to decrease use and costs for chronic kidney disease, ischemic heart disease, atrial fibrillation, depression, and hypertension.
Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds
Authors: Ge Yan , Tang Jiapeng , Fu Haihong , Fu Yijun 
Published: July 2020

AbstractChronic wounds are susceptible to infection and difficult to heal due to the complex healing process and terrible microenvironment. In order to overcome this problem, TOLs‐CS/PEO nanofibrous film was successfully electrospun. The 6%(v/v) TOLs incorporation into CS/PEO nanofibrous film could improve the morphology and structure of nanofibers, weaken the interactions among macromolecules and rebalance the relationship between hydrophilicity and hydrophobicity of pore surface. Water vapor transmission rate and simulated tissue fluid absorption of films were optimized to reach 2193 g m−2 d−1 and 1676% so that to obtain the excellent moisture retention. The Young's modulus and elongation at break of films in wet state were 114.69 kPa and 72.04%, respectively, causing the mechanical characteristics similar to human skin. The film could effectively block more than 98% of bacteria and inhibit bacteria growth besides possessing procoagulant property and suitable biodegradability. These findings demonstrate that TOLs‐CS/PEO nanofibrous film can construct a microenvironment suitable for wound healing.
American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID‐19 Pandemic: Version 2
Authors: Mikuls Ted R. , Johnson Sindhu R. , Fraenkel Liana , Arasaratnam Reuben J. , Baden Lindsey R. , Bermas Bonnie L. , Chatham Winn , Cohen Stanley , Costenbader Karen , Gravallese Ellen M. , Kalil Andre C. , Weinblatt Michael E. , Winthrop Kevin , Mudano Amy S. , Turner Amy , Saag Kenneth G. 
Published: July 2020

ObjectiveTo provide guidance to rheumatology providers on the management of adult rheumatic disease in the context of the coronavirus disease 2019 (COVID‐19) pandemic.MethodsA task force, including 10 rheumatologists and 4 infectious disease specialists from North America, was convened. Clinical questions were collated, and an evidence report was rapidly generated and disseminated. Questions and drafted statements were reviewed and assessed using a modified Delphi process. This included asynchronous anonymous voting by e‐mail and webinars with the entire panel. Task force members voted on agreement with draft statements using a 1–9‐point numerical scoring system, and consensus was determined to be low, moderate, or high based on the dispersion of votes. For approval, median votes were required to meet predefined levels of agreement (median values of 7–9, 4–6, and 1–3 defined as agreement, uncertainty, or disagreement, respectively) with either moderate or high levels of consensus.ResultsTo date, the task force has approved 80 guidance statements: 36 with moderate and 44 with high consensus. These were combined, resulting in 27 final guidance statements.ConclusionThese guidance statements are provided to promote optimal care during the current pandemic. However, given the low level of available evidence and the rapidly evolving literature, this guidance is presented as a “living document,” and future updates are anticipated.
Bericht des Arbeitskreises Baugruben: Hinweise zur 6. Auflage der EAB
Authors: Hettler Achim , Becker Patrick , Borchert Kurt‐Michael , Kempfert Hans‐Georg , Kinzler Steffen 
Published: July 2020

AbstractMit der 151. Sitzung am 30. Januar 2020 in Köln konnte der Arbeitskreis „Baugruben“ die Überprüfung und Anpassung aller Kapitel im Rahmen der geplanten 6. Auflage abschließen. Es wurde ein kleines Redaktionsteam gebildet, das nach sieben Webkonferenzen die finalen Versionen der einzelnen Kapitel fertiggestellt und an den Verlag weitergeleitet hat. Im Beitrag werden die wesentlichen Änderungen seit dem Jahresbericht 2019 vorgestellt.
An Engineered Escherichia coli Strain with Synthetic Metabolism for in‐Cell Production of Translationally Active Methionine Derivatives
Authors: Schipp Christian Johannes , Ma Ying , Al‐Shameri Ammar , D'Alessio Federico , Neubauer Peter , Contestabile Roberto , Budisa Nediljko , di Salvo Martino Luigi 
Published: July 2020

AbstractIn the last decades, it has become clear that the canonical amino acid repertoire codified by the universal genetic code is not up to the needs of emerging biotechnologies. For this reason, extensive genetic code re‐engineering is essential to expand the scope of ribosomal protein translation, leading to reprogrammed microbial cells equipped with an alternative biochemical alphabet to be exploited as potential factories for biotechnological purposes. The prerequisite for this to happen is a continuous intracellular supply of noncanonical amino acids through synthetic metabolism from simple and cheap precursors. We have engineered an Escherichia coli bacterial system that fulfills these requirements through reconfiguration of the methionine biosynthetic pathway and the introduction of an exogenous direct trans‐sulfuration pathway. Our metabolic scheme operates in vivo, rescuing intermediates from core cell metabolism and combining them with small bio‐orthogonal compounds. Our reprogrammed E. coli strain is capable of the in‐cell production of l‐azidohomoalanine, which is directly incorporated into proteins in response to methionine codons. We thereby constructed a prototype suitable for economic, versatile, green sustainable chemistry, pushing towards enzyme chemistry and biotechnology‐based production.
A case of oral cancer with delayed occipital lymph node metastasis: Case report
Authors: Ono Kisho , Yoshioka Norie , Masui Masanori , Obata Kyoichi , Kunisada Yuki , Okui Tatsuo , Ibaragi Soichiro , Kawai Hotaka , Nagatsuka Hitoshi , Sasaki Akira 
Published: July 2020

AbstractConsideration of unexpected metastasis in patients who have undergone neck dissection with advanced tumors must be anticipated with careful follow‐up.
Challenges in the management of acute intermittent porphyria with recurrent attacks during pregnancy: A case report
Authors: Vassiliou Daphne , Lempessi Chariklia , Harper Pauline , Sardh Eliane 
Published: July 2020

AbstractIn cases of recurrent attacks of acute porphyria during pregnancy, prophylactic administration of heme arginate should be considered. Clinical and biochemical monitoring of the disease and a close collaboration with a porphyria center are crucial.
Synthesis of dibenzo[a,j]phenazine compounds using hemicucurbit[6]uril‐catalyzed oxidative dimerization of 2‐arylamines
Authors: Li Heng , Yu Juan , Ge Qingmei , Liu Mao , Tao Zhu , Cong Hang 
Published: July 2020

AbstractA supramolecular catalytic strategy for the synthesis of dibenzo[a,j]phenazine compounds from 2‐arylamines is demonstrated. The dimerization is achieved through the catalytic action of HemiQ[6] in an acidic environment. Kinetic constants and activation energies have been calculated through UV/Vis spectrophotometric investigations using different amounts of HemiQ[6], whereby the reactivity was found to be related to the electron densities of the substrates. A possible mechanism involving host‐guest interaction between a 2‐arylaminium salt and HemiQ[6] through hydrogen‐bonding is proposed. The transformation of 2‐arylamines to dibenzo[a,j]phenazines in the presence of HemiQ[6] suggests that such supramolecular catalysis is effective for such constructions.
Long‐term predictive value of stroke volume index obtained from right heart catheterization: Insights from the veterans affairs clinical assessment, reporting, and tracking program
Authors: Bavry Anthony A. , Hess Edward , W Waldo Stephen , Barón Anna E. , Kumbhani Dharam J. , Bhatt Deepak L. , Pandey Ambarish 
Published: July 2020

AbstractBackgroundRight heart catheterization‐derived hemodynamic parameters have been associated with short‐term prognosis.HypothesisHemodynamic parameters will be associated with long‐term prognosis.MethodsRetrospective cohort study from the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program included patients who underwent an index right heart catheterization between 2008 and 2016. Cox proportional hazard models were used to examine the association between stroke volume index and all‐cause mortality.ResultsFor the final cohort of 37 209 patients, mean follow‐up was 3.7 ± 2.5 years. All‐cause mortality was 42.0% in the low (<35 cc/beat/m2) compared with 33.2% in the normal stroke volume index group (≥35 cc/beat/m2). In adjusted analysis, low stroke volume was significantly associated with higher mortality risk (HR (95% CI) 1.14 (1.10‐1.18); P < .001) independent of clinical parameters. The area under the curve (AUC) for continuous measures of stroke volume index at predicting mortality in a Cox proportional hazard model was 0.56 at 3 years. When stroke volume index was combined with 14 clinical covariates, the AUC was 0.70 at 3 years. The addition of stroke volume index to these clinical covariates did not increase the discriminatory ability of the model at 1 year in a clinically meaningful way (integrated discrimination improvement index = 0.0021, 95% CI: 0.0010‐0.0034).ConclusionsThe long‐term prognostic value of right heart catheterization‐derived stroke volume index appears to be marginal. While there was a weak association of low stroke volume index and excess mortality, inclusion of this parameter to a set of clinical covariates did not improve prognostic discrimination.
Activity‐Directed Synthesis: A Flexible Approach for Lead Generation
Authors: Karageorgis George , Liver Samuel , Nelson Adam 
Published: July 2020

AbstractActivity‐directed synthesis (ADS) is a structure‐blind, functional‐driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses reactions with multiple possible outcomes, and allows many chemotypes to be evaluated in parallel. Resources are focused on bioactive molecules, which emerge in tandem with associated synthetic routes. Some of the future challenges for ADS are highlighted, including the realisation of an autonomous molecular discovery platform. The prospects for ADS to become a mainstream lead generation approach are discussed.