bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive control of a water distribution system based on process historian data
Authors: Salvador Jose R. , Muñoz de la Peña D. , Ramirez D.R. , Alamo T. 
Published: December 2019

SummaryIn this paper, a heuristic historian data‐based predictive control strategy is presented and used to control a water distribution system simulated using the EPANET software, in particular, the Richmond water distribution system. The control actions are computed based on past historian data. The historian stores closed‐loop operation data of the process with different controllers used in the past, which may not provide sufficient information for a precise system nor controller identification. The proposed predictive controller computes the current control actions as a weighted sum of past control actions so that an estimation of the performance cost over a prediction horizon is minimized. Only a subset of the past control actions in the historian close to the current state of the process is considered in the current control computations to carry out a local linearization. This predictive strategy is well suited to control applications of large and complex processes for which it is difficult to carry out identification experiments such as water distribution systems. In the application example, the trajectories of a set of relay controllers are used through the proposed approach to take into account pressure constraints and periodic references.
Reduction of IL‐6 gene expression in human adipose tissue after sleeve gastrectomy surgery
Authors: Casimiro Isabel , Hanlon Erin C. , White Jeremy , De Leon Avelino , Ross Ruby , Moise Katiannah , Piron Matthew , Brady Matthew J. 
Published: December 2019

SummaryObjectiveThere is increasing evidence that immune cell interactions in adipose tissue contribute to the development of metabolic dysfunction. Pro‐inflammatory cytokines have been shown to mediate insulin resistance, and the presence of macrophages is a salient feature in the development of obesity. The present study aimed to evaluate adipocyte size and macrophage activation in women before and 3 months after laparoscopic vertical sleeve gastrectomy (VSG).MethodsSubcutaneous abdominal adipose tissue biopsies were obtained from women scheduled to undergo VSG. Histological evaluation of adipocytes and macrophages was performed as well as cytokine expression quantification before and after VSG‐induced weight loss.ResultsWeight loss following VSG resulted in a reduction in adipocyte size as well as a decrease in interleukin (IL)‐6 cytokine mRNA expression in subcutaneous adipose tissue. There was no change in the presence of crownlike structures after weight loss.ConclusionsEarly weight loss after VSG is associated with a reduction in adipocyte size and a decline in IL‐6 gene expression in local adipose tissue. Macrophage infiltration and crownlike density structures persist in adipose tissue from tissues impacted by excess body weight 3 months after VSG‐induced weight loss.
Proteomic Profile of Human Schwann Cells
Authors: Ferdoushi Aysha , Li Xiang , Jamaluddin Muhammad Fairuz Bin , Hondermarck Hubert 
Published: December 2019

AbstractSchwann cells (SC) are essential for the growth, maintenance, and regeneration of peripheral nerves, but the proteome of normal human SC is poorly defined. Here, a proteomic analysis by LC–MS/MS is performed to define the protein expression profile of primary human SC. A total of 19 557 unique peptides corresponding to 1553 individual proteins are identified. Ingenuity Pathway Analysis (IPA), Gene Ontology (GO), and Database for Annotation, Visualization, and Integrated Discovery (DAVID) are used to assign protein localization and function, and to define enriched pathways. EIF2, mTOR, and integrin signaling are among the most enriched pathways and the most enriched biological function is cell–cell adhesion, which is in agreement with the supportive role of SC in peripheral nerves. In addition, several nociceptors and synaptic proteins are identified and may contribute to the recently discovered role of SC in pain sensation and cancer progression. This proteome analysis of normal human SC constitutes a reference for future molecular explorations of physiological and pathological processes where SC are involved.
Absolute spatially and time‐resolved O, O3, and air densities in the effluent of a modulated RF‐driven atmospheric pressure plasma jet obtained by molecular beam mass spectrometry
Authors: Jiang Jingkai , Luo Yuchen , Moldgy Ankit , Aranda Gonzalvo Yolanda , Bruggeman Peter J. 
Published: December 2019

AbstractIn this paper, we report a molecular beam mass spectrometer study of a time‐modulated radiofrequency (RF)‐driven atmospheric pressure plasma jet in Ar + 1% O2. Time‐resolved measurements of the absolute density of O3 during the RF modulation period revealed a temporal increase of O3 densities at the start and end of the power modulation. This increase correlates with the increase in O2 due to plasma‐induced transient vortices in the gas jet. Pseudo‐one‐dimensional plug flow modeling of the axial species densities as a function of distance match well with the experimentally recorded trends. The obtained results were used to assess the importance of the O flux in previously reported ClO− production in saline by the same plasma jet.
Evaluating the centralized purchasing policy for the treatment of hepatitis C: The Colombian CASE
Authors: Pérez Angela V. , Trujillo Antonio J. , Mejia Aurelio E. , Contreras Johnny D. , Sharfstein Joshua M. 
Published: December 2019

AbstractThe high cost of drugs for hepatitis C limits access and adherence to treatment. In 2017, the Colombian health care system decided to design a strategy. It consisted of centralized purchasing, regulations, clinical practice guidelines, and direct observation of the treatment and follow‐up of patients. The main objective of this study was to assess the centralized purchasing strategy in Colombia. The study design was a policy implementation assessment. We analyzed the change in prices, the clinical outcomes, and the opinions of stakeholders using data from the Ministry of Health. Additional information about effectiveness came from the Colombian Fund for High‐Cost Diseases and semi‐structured interviews of the stakeholders. The follow‐up was from October, 2017 to October, 2018. The total number of patients reported in the cohort period was 1069. The number that finished 12 weeks of treatment, completed the follow‐up for the case closure, and were considered cured through the end of October, 2018 was 563 (53%). The remainder, 506 patients (47%), are currently in treatment. A total of 543 of these treated patients (96%) were cured. After implementing this strategy, the drug prices decreased by more than 90% overall. Before implementation, the total direct cost was $100 102 171.75 dollars. Afterward, the cost was $8 378 747 dollars.
Constraining stochastic parametrisation schemes using high‐resolution simulations
Authors: Christensen Hannah M. 
Published: December 2019

AbstractStochastic parametrisations can be used in weather and climate models to improve the representation of unpredictable unresolved processes. When compared with a deterministic model, a stochastic model represents “model uncertainty”, that is, sources of error in the forecast due to the limitations of the forecast model. A technique is presented for systematically deriving new stochastic parametrisations or constraining existing stochastic approaches. A high‐resolution model simulation is coarse‐grained to the desired forecast model resolution. This provides the initial conditions and forcing data needed to drive a single‐column model (SCM). Comparing the SCM parametrised tendencies with the evolution of the high‐resolution model provides an estimate of the error in the SCM tendencies that a stochastic parametrisation seeks to represent. This approach is used to assess the physical basis of the widely used stochastically perturbed parametrisation tendencies (SPPT) scheme. Justification is found for the multiplicative nature of SPPT, along with some evidence for the use of spatio‐temporally correlated stochastic perturbations. Evidence that the stochastic perturbation should be positively skewed is found, indicating that occasional large‐magnitude positive perturbations are physically realistic. However, other key assumptions of SPPT are less well justified, including coherency of the stochastic perturbations with height, coherency of the perturbations for different physical parametrisation schemes, and coherency for different prognostic variables. Relaxing these SPPT assumptions allows for an error model that explains a larger fractional variance than traditional SPPT. In particular, it is suggested that independently perturbing the tendencies associated with different parametrisation schemes is justifiable and would improve the realism of the SPPT approach.
Self‐Assembled InAs/GaAs Coupled Quantum Dots for Photonic Quantum Technologies
Authors: Jennings Cameron , Ma Xiangyu , Wickramasinghe Thushan , Doty Matthew , Scheibner Michael , Stinaff Eric , Ware Morgan 
Published: December 2019

AbstractCoupled quantum dots (CQDs) that consist of two InAs QDs stacked along the growth direction and separated by a relatively thin tunnel barrier have been the focus of extensive research efforts. The expansion of available states enabled by the formation of delocalized molecular wavefunctions in these systems has led to significant enhancement of the already substantial capabilities of single QD systems and have proven to be a fertile platform for studying light–matter interactions, from semi‐classical to purely quantum phenomena. Observations unique to CQDs, including tunable g‐factors and radiative lifetimes, in situ control of exchange interactions, coherent phonon effects, manipulation of multiple spins, and nondestructive spin readout, along with possibilities such as quantum‐to‐quantum transduction with error correction and multipartite entanglement, open new and exciting opportunities for CQD‐based photonic quantum technologies. This review is focused on recent CQD work, highlighting aspects where CQDs provide a unique advantage and with an emphasis on results relevant to photonic quantum technologies.
Data‐based iterative learning mechanism for unknown input‐output coupling parameters/matrices
Authors: Liu Jian , Chen Weisheng , Ruan Xiaoe , Zheng Yuanshi 
Published: December 2019

SummaryIn this paper, we explore how to get the information of input‐output coupling parameters (IOCPs) for a class of uncertain discrete‐time systems by using iterative learning technique. Firstly, by taking advantage of repetitiveness of control system and informative input and output data, we design an iterative learning scheme for unknown IOCPs. It is shown that we can get the exact values of IOCPs one by one through running the repetitive system T+1 times if the control system is with identical initial state and noise free. Secondly, we give the iterative learning scheme for unknown IOCPs in the presence of measurement noise, system noise, or initial state drift and analyze the influence factors on the performance of developed iterative learning scheme. Meanwhile, we introduce the maximum allowable control deviation into the iterative learning mechanism to minimize the negative impact of noise on the performance of learning scheme and to enhance the robust of iterative learning scheme. Thirdly, for a class of multiple‐input–multiple‐output systems, we also develop iterative learning mechanism for unknown input‐output coupling matrices. Finally, an illustrative example is given to demonstrate the effectiveness of proposed iterative learning scheme.
Self‐Assembly of Di‐Guanine Peptide Nucleic Acid Amphiphiles into Fractal Patterns
Authors: Abraham Jancy N. , Pawar Prabhakar , Kootteri Dilna K. 
Published: December 2019

AbstractPeptide nucleic acids (PNAs) amphiphiles have been reported to assemble into different nanostructures; however, there is immense untapped potential to control their supramolecular assemblies by altering their lipid chain. Here, we functionalized di‐guanine PNA with various hydrophobic appendages, namely dodecyl, p‐dodecylbenzoyl and pentadecyl phenol groups, to investigate the effect of aromatic linkers, long alkyl and alkoxyl substituents on hierarchical self‐assembly of di‐guanine PNA. Systematic electron microscopy and atomic force microscopy studies revealed that while all three derivatives of di‐guanine‐PNA formed nanospheres, only nanospheres of dodecylamide and pentadecyl phenol derivatives matured into nanorods, these later formed higher order fractal assemblies. Furthermore, we observed that inclusion of a positively charged lysine at the C‐terminus prevented fractal assembly, possibly due to electrostatic repulsion between the head groups. Thus, the findings of the present work might guide rational design of PNA amphiphiles to obtain specific self‐assembled morphology.
Achieving Different Morphologies for a Zinc(II) Coordination Polymer by Green Sonochemical Synthesis and New Precursors for the Preparation of Zinc(II)oxide
Authors: Souri Bagher , Rezvani Ali Reza , Hayati Payam , Centore Roberto 
Published: December 2019

AbstractA new 2D zinc(II) coordination polymer(CP) 1, [Zn(N3)(L)]n(1), [L= 2‐picolinate] has been synthesized using branch tube approach. Nano and micro structures of CP 1 were synthesized using sonochemical technique in diverse conditions (different times and solvents) and they were identified by elemental analysis, FT‐IR spectra, scanning electron microscopy (SEM) and powder X‐ray diffraction (PXRD). Single‐crystal X‐ray studies show that CP1 contains Zn(II) atoms with different coordination geometries (tetrahedral and octahedral). The effects of solvents and reaction time on the morphology and size of the nano and microstructure of CP 1 were also evaluated. The results showed that change in reaction time has almost no effect on the size of particles, but change in solvent leads to changes in the morphology of particles.
Gold Nanoparticles Stabilized by Sulfonated‐Imidazolium Salts as Promising Catalyst in Water
Authors: Monti Gustavo A. , Correa N. Mariano , Falcone R. Darío , Silbestri Gustavo F. , Moyano Fernando 
Published: December 2019

AbstractWe present the total characterization (by FT‐IR and NMR spectroscopies) of gold nanoparticles (Au‐NPs) stabilized by different sulfonated‐imidazolium salts. Also, thermogravimetric analysis (TGA) was used in order to evaluate the degree of the Au‐NPs coverage. Our results show how the orientation of the sulfonated‐imidazolium salts and, the interaction of the hydrocarbon chain with the Au‐NP surface are responsible for the strength of the ligand‐Au‐NP interaction. The developed procedure is easy, fast and reproducible to carry out different catalytic organic reactions in water. Our preliminary studies indicate that Au‐NPs synthesized are active and recyclable catalysts for the reduction of aromatic nitro compounds at room temperature in water.
Synthesis and Acid Catalyzed Rearrangement of Cage Propellanes
Authors: Kotha Sambasivarao , Cheekatla Subba Rao 
Published: December 2019

AbstractThe design and synthesis of highly decorated cage [4.3.2]propellanes and D3‐trishomocubanes have been reported via ring‐closing metathesis (RCM), [4+2] cycloaddition and acid‐catalyzed rearrangement as key steps. These cage polycycles were prepared starting with inexpensive synthons such as 2,5‐dimethoxybenzaldehyde and endo‐dicyclopentadiene. Propellanes containing fused spiro[4.4]nonane ring system was realized by RCM protocol. Interestingly, the dimethoxy cage propellane derivative was observed instead of the rearranged product with Lewis acid such as BF3⋅MeOH. Several intricate cage structures were synthesized from rearrangement approach that are difficult to generate by conventional routes.
Synthesis, Characterization and DFT Molecular Modeling of New Antibacterial Docked Dicarbohydrazones
Authors: Abu‐Melha Sraa 
Published: December 2019

AbstractFive new dicarbohydrazones 3 a‐e were prepared from condensation of 9,10‐dihydro‐9,10‐ethanoanthracene‐11,12‐dicarbohydrazide (2) with various aryl/heteroaryl aldehydes. A DFT method has been employed to predict the geometry, bond lengths, and bond angles as well as other global chemical reactivity of the prepared dicarbohydrazones. In addition, the docking study of these synthesized dicarbohydrazones was applied against negative Escherichia coli bacterial strain by Schrödinger suite program using the XP glide dock protocol. Furthermore, the antibacterial activity of these dicarbohydrazones indicated that compound 3 b and 3 e exhibited the higher inhibition against E. coli with a percentage of 100% and 95.45%.
Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting
Authors: Giachino Carmela , Viale Maurizio , Vecchio Graziella 
Published: December 2019

AbstractSome nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on β‐cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.
Strongly Coupled Amorphous Porous NbOx(OH)y/g‐C3N4 Heterostructure Composite for Efficient Photocatalytic Hydrogen Evolution
Authors: Zhang Yuelan , Li Liping , Han Dong , Fu Sixian , Liu Yan , Han Bingqi , Yang Min , Li Guangshe 
Published: December 2019

AbstractHeterostructure composites are promising materials in photocatalytic hydrogen evolution due to their advantage on promoting photogenerated carrier separation efficiently. However, the weak interfacial interaction can block electron transfer and complicate synthesis methods restrict the practical application of catalysts. Here, we report an interfacial enhanced amorphous porous NbOx(OH)y/g‐C3N4 heterostructure composite through a spontaneous coupling process. It was characterized by XRD, TEM, FT‐IR, XPS, NH3‐TPD and CO2‐TPD, ect., which demonstrated that NbOx(OH)y possess amorphous porous structures with high specific surface area (205 m2/g) and plenty of acidic sites (418 μmol/g) as well as basic sites (184 μmol/g) contributed from uncoordinated Nb and ‐OH. These acidic and basic sites electrostatically attract ‐NHx and C‐OH on the surface of g‐C3N4 to form hydrogen bonds (Nb‐O‐H⋅⋅⋅NH2, Nb‐O⋅⋅⋅H‐O‐C), showing a strong electron interaction between NbOx(OH)y and g‐C3N4. When tested as a photocatalyst for water splitting under visible light, the optimal NbOx(OH)y/CN‐0.05 heterostructure composite exhibits a hydrogen evolution rate of 53 μmol/g/h, which is about 14 times higher than that of g‐C3N4 (3.8 μmol/g/h) and is even superior than P25 (16 μmol/g/h). These present findings lay a foundation for the synthesis of strongly interacting heterogeneous composites.
Urea‐assisted Strategy Controlling The Pore Structure And Chemical Composition Of The Porous Carbon For High‐performance Supercapacitors
Authors: Wang Keke , Chen Mingming , Zhu Youyu , Liu Kunlin , Zhang Yang , Wang Chengyang 
Published: December 2019

AbstractPorous carbon prepared by chemical activation with low KOH consumption always exhibits low SSA and micropore‐dominated porosity, which limits its application in non‐aqueous EDLCs. Herein, a facile strategy simultaneously combining pore structure and chemical composition controlling was developed to prepare nitrogen‐doped hierarchical porous carbon frameworks (N‐HPC) from low‐cost sulfonated pitch (SP). It was realized by utilizing the “function effect” of urea to introduce nitrogen‐containing heterocyclic units, which could enhance the “in‐suit etching” of activator to develop the porosity. Different from the sample that prepared only using KOH, the final activated sample with the help of urea not only delivers a high specific area (3054 m2 g−1) with mesopore‐dominated porosity, but also exhibits a high nitrogen content of 4.2 at. %. These distinct features afford a high specific capacity of 142 F g−1 at 20 A g−1 (C20/C0.05 of 79.7%), enhanced energy density 48.7 Wh kg−1 at 14.45 kW kg−1 and excellent cyclic stability (90.4% retention after 10000 cycles) in EMIMBF4 electrolyte. Our work may provide a new insight for design of N‐HPC with low KOH consumption in energy storage fields.
Iron‐Catalyzed Crossed‐Aldol Condensation for the Synthesis of 3‐Benzylidene‐4‐chromanones: An Efficient Synthesis of Homoisoflavanoids†
Authors: Shaikh Nadim S. , Kushalappa Yeshma M. , Sheshappa Swathi P. , Nagaraju Hareesh H. 
Published: December 2019

AbstractA new, convenient and sustainable protocol for the aldol condensation of chroman‐4‐one derivatives with aldehydes using iron as a catalyst under microwave irradiation in the presence of green solvent (2‐methyl‐THF) is presented. The protocol offers a very simple, cost efficient and environmentally benign procedure with good to excellent yields of 3‐benzylidene‐4‐chromanone derivatives. The methodology is demonstrated to be useful for the synthesis of homoisoflavanoids Boundecullin, Sappanone A and their derivatives. The present method offers a potential to generate a quick library of homoisoflavanoids and their synthetic derivatives of medicinal importance.
Triarylamine‐Bonded Binaphthyl Derivatives as Fluorescence Quenching Probes for Fe3+: An Insight into the Mechanism Based on A Single Binding Site
Authors: Huang Qiaoxi , Peng Zhixing , Xie Xinrui , Tang Zefeng , Lei Ming 
Published: December 2019

AbstractTriphenylamine (TPA) and binaphthyl (BINAP) have been widely used as building blocks in optoelectronics materials for their good electron donating and transport capability. However, TPA‐bonded BINAP type of fluorescent probe towards Fe3+, a kind of important metal ion, has not been studied. Herein, a series of TPA‐bonded BINAP D−A‐D type derivatives, 6,6‐TB‐1, 6,6‐TB‐2, 7,7‐TB‐1, 7,7‐TB‐2, and 7,7‐OMeTB‐1, was synthesized to investigate their fluorescence (FL) chemosensor properties and electronic effect on sensitivity. Results showed that these probes exhibited highly selective FL quenching toward Fe3+ in the presence of other common metal ions, and an enhanced sensitivity (limit of detection 1.7×10−7 M) not inferior to that of other works, could be achieved by introducing electron‐donating substituent into TPA group. Then, comprehensive studies, such as NMR, EPR, MALDI‐TOF‐MS, and XPS combined with Mulliken atomic charges analysis were performed to gain an insight into the probe's binding with Fe3+ to understand the detection mechanism. Compared with other works on TPA‐based fluorescent probes ascribed to fluorescence resonance energy transfer (FRET) or charge transfer (CT) mechanism, we reveal the interaction between Fe3+ and N atom of TPA and the formation of probe‐Fe3+ complex leading to FL quenching. This work provides a simple strategy for designing a cost‐effective Fe3+ fluorescent probe based on a single binding site to target one specific analyte.