bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical aspects of the management of stable coronary artery disease in primary care practice or how to increase the efficacy of evidence-based pharmacological therapy?
Authors: Zyryanov Sergey K. , Fitilev Sergey B. , Vozzhaev Alexander V. , Shkrebniova Irina I. , Klyuev Dmitry A. 
Published: September 2020

Introduction: The publication describes a fragment of the pharmacoepidemiologic study conducted to review the quality of management of patients with stable coronary artery disease (SCAD) in primary care over a 12-year period. The aim of the study was to justify the application of standard operating procedures (SOPs). Such determinants of pharmacotherapy as non-pharmacological modification of cardiovascular risk factors (RFs) and medication adherence were analyzed.
Material and methods: A retrospective, cross-sectional, 3-stage (2006, 2011, 2018) study was conducted in a primary care setting of Moscow. As many as 3027, 1834, 805 patients with verified diagnosis of SCAD were included. De­mographics, medical history, data on modifiable RFs and prescribed drug therapies were collected. At the third stage, medication adherence was measured, using the 8-item Morisky scale.
Results and discussion: Over a 7-year period, better control of modifiable RFs in coronary patients was revealed. The target levels of blood pressure were reached in 58.3% (+20.7%; p < 0.05) of the patients, total cholesterol – in 33.0% (+16.0%; p < 0.05), and low-density lipoprotein cholesterol – in 23.3% (+12.2%; p < 0.05). Two critical problems that determined still inadequate RFs control were identified. The attention of physicians to RFs and rates of non-pharma­cological interventions remained low throughout the study. Information on lifestyle RFs was recorded in fewer than one-third of the subjects. The lipid profile was registered only in half of patients’ histories. Non-adherence to pharma­cotherapy was identified in 51.3% of patients.
Conclusion: Further increase in efficacy of pharmacotherapy might be provided by application of SOPs regarding the registration and correction of modifiable cardiovascular RFs, identification of non-adherent patients and promotion of medication adherence.
Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals
Authors: Maltsev Dmitriy V. , Spasov Alexander A. , Miroshnikov Mikhail M. , Skripka Maria O. , Divaeva Ludmila N. 
Published: September 2020

Introduction: Diazepino[1,2-a]benzimidazole derivatives showed anxiolytic (EPM, L/D box, Vogel test), antidepres­sant (Tail Suspension test, Porsolt test), anticonvulsant (Pentylenetetrazole-Induced seizures) and analgesic (Tail-Flick, Hot Plate) actions, which were described earlier (Spasov et al. 2020). 11-(4-tert-butylbenzyl)-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole hydrobromide (compound DAB-19) has evident anxiolytic, antidepressant and anticon­vulsant effects. In the present study, compound DAB-19 was screened for its influence on animals` behavior patterns, such as aggression, obsessive-compulsive behavior, emotional lability, and unsociability.
Materials and methods: 112 outbred white animals (rats and mice) were used. Compound DAB-19 (2.34 mg/kg, p.o.) and diazepam (2 mg/kg, p.o.) were injected to the treatment groups. Using an Open Field (OF) test, we evaluated a spontaneous motor activity, a search activity of mice and a degree of their emotionality. During a Marble Burying (MB) test, we monitored anxiolytic and anticompulsive effects of DAB-19. Using a Resident-intruder (RI) test, we evaluated a degree of aggression in the experimental animals, properties of their social interaction, as well as defensive and individual behavior.
Results and discussion: Compound DAB-19 has positive influence on the search activity, mood stabilizing activity and antiaggressive actions. Administration of both DAB-19 (2.34 mg/kg, p.o.) and diazepam (2 mg/kg, p.o.) reduced anxiety-like behavior in OP, RI and MB tests, as indicated by a significantly increased number of entries to the center of OP; a decreased number of marbles buried in MB and reduced aggressive behavior in RI. It was stated that using DAB-19 leads to a decrease in affective reactions of the animals – aggression, obsessive-compulsive behavior, neurotic condition and emotional instability.
Conclusions: The compound (DAB-19) produces anxiolytic-like effects, compared with those of diazepam, in various anxiety paradigms.
Steel in Britain before and after Benjamin Huntsman: manufacture and consumption in the eighteenth century
Authors: Evans Chris 
Published: September 2020

Cet article propose une synthèse sur les modes de fabrication et de commercialisation de l’acier en Grande-Bretagne au xviiie siècle. Au milieu du xviie siècle, la Grande-Bretagne occupait une place marginale dans la production d’acier en Europe ; ses fabricants étaient dépendants d’importations allemandes. Un siècle plus tard, la Grande-Bretagne était devenue le centre le plus dynamique de production d’acier en Europe. Ce texte se propose d’analyser ces changements. Deux transformations sont importantes : la diffusion des techniques de cémentation pour convertir le fer en « blister steel », dans les dernières années du xviie siècle, et le succès des marchands britanniques pour s’assurer le contrôle du fer suédois dit « Orground » – un ingrédient essentiel pour la cémentation – au tout début du xviiie siècle. Il nous semble donc que l’innovation la plus célèbre de l’acier britannique au xviiIe siècle, l’acier fondu de Benjamin Huntsman dans les années 1740, ait revêtu finalement une importance limitée. Les marchés spécifiques de l’acier fondu, distincts de ceux du « blister steel », restent en effet très limités avant le début du xixe siècle.
La fabrique du regard
Authors: Pentimalli Barbara , Rémery Vanessa 
Published: September 2020

Cette introduction au dossier thématique explore le paysage de l’anthropologie du regard et montre en quoi il relève d’une activité sémiologique au cœur de l’expertise professionnelle. Elle souligne l’originalité du dossier : documenter les formes socio-matérielles par le biais desquelles ce savoir-voir est transmis aux novices à travers le prisme des métiers dont « les façons de voir » sont éprouvées, questionnées, reconfigurées dans leur fondement et leurs frontières. Des thématiques transversales y sont traitées : la construction du savoir-voir, sa dimension multisensorielle et multimodale, les méthodologies permettant de documenter son apprentissage et son développement, enfin ses étayages techniques et technologiques. L’objectif est de valoriser la diversité des terrains, des méthodologies et des approches proposés dans ce dossier explorant le rôle des habiletés visuelles dans la production, la circulation et la transformation des ‘façons de voir’ de différentes communautés de pratique.
Role of Pain-Related Evoked Potential in the Diagnosis of Meralgia Paresthetica
Authors: Ahmed Shaikh Atif Iqbal , Das Monika , Roy Anupama , Baby Bini , Dhar Dolcy , Abigayil Jebalin , Varghese Vitty Susan , Mathew Vivek , Aaron Sanjith , Sivadasan Ajith , Premkumar Paul , Suresh Tharan , Prabhakar Appaswamy Thirumal 
Published: September 2020

Introduction:
Entrapment of the lateral femoral cutaneous nerve (LFCN) of thigh results in meralgia paresthetica (MP). Standard electrophysiological tests for MP are technically demanding and unreliable. We aimed to study the role of pain-related evoked potentials (PREP) in the diagnosis of MP.

Methods:
Patients with MP and normal volunteers were included. PREP was recorded by stimulating the skin over the lateral thigh 20 cm below the anterior-superior iliac spine and recording from the cortex at Cz.

Results:
A total of 28 subjects and 56 LFCNs were studied. 36 nerves had MP and 20 were normal. The mean PREP latency was 118 (8) ms among normal controls and 164 (10.8) ms in MP. The optimal cut-off point for the diagnosis of MP was 134 ms. Area under receiver operator characteristic curve was 0.97; sensitivity was 91.7% and specificity was 100%.

Conclusion:
PREP is reliable and easy to use electrophysiological test in establishing the diagnosis of MP.
Oral Hygiene Status of Patients with Tonsillitis and Tonsilar Hyperplasia in a Teaching Hospital
Authors: Adetayo Adekunle Moses , Akinola Ayodele Moses , Taiwo Abdurazzak Olanrewaju , Adetayo Modupe Olusola 
Published: September 2020

Background:
The number of recurrent tonsillitis and tonsillar hyperplasia requiring tonsillectomies annually is huge. Poor oral hygiene has been linked with the occurrence of these tonsillar diseases. The main objective of the present study is to determine the oral hygiene status of patients treated for tonsillitis and/or tonsillar hyperplasia at our hospital.

Methods:
This was a prospective case series of participants with tonsillitis or tonsillar hyperplasia at our hospital from 2018 to 2020.

Results:
A total of 80 participants with tonsillitis/or tonsillar hyperplasia were recruited into the study within August 2016 and March 2017 comprising 49 (61.3%) females and 31 (38.7%) males, with age ranging from 16 to 32 years (18.27 ± 4.21).

Conclusions:
The present study demonstrated a high proportion of less than optimal oral hygiene status in participants with tonsillitis/or tonsilar hyperplasia. This suggests that there might be an association between oral hygiene and tonsillitis/or tonsilar hyperplasia. Further research is, however, needed to prove this.
Identification of Autophagy-related Protein 3 in the Ancient Protist Trichomonas vaginalis
Authors: Tsao Chang-Huei , Lin Hsin-An , Lin Hsin-Chung , Chen Ruei-Min , F. Chen Chien-Fu , Lin Yu-Chun , Huang Kuo-Yang 
Published: September 2020

Background:
Autophagy has been suggested to be involved in the pathogenesis of protists. While the molecular mechanisms of autophagy are mainly studied in model organisms, functional characterization of autophagy-related (Atg) proteins is poorly understood in deep-branching protists. Trichomoniasis is the most common nonviral sexually transmitted infection caused by Trichomonas vaginalis. Bioinformatics analysis of the T. vaginalis genome reveals that the parasite possesses the genes encoding proteins of the Atg8 conjugation system. Herein, we sought to characterize whether the T. vaginalis Atg3 ortholog (TVAG_447140), a putative component of the TvAtg8 conjugation system, regulates autophagy in this parasite.

Methods:
The recombinant protein of T. vaginalis Atg3 ortholog (TvAtg3) (rTvAtg3) and the polyclonal antibody against rTvAtg3 were generated. The expression and localization was monitored upon autophagy induction by glucose restriction (GR) compared with glucose-rich cultivation. The role of TvAtg3 in autophagy was clarified using small interfering RNA targeting TvAtg3 gene.

Results:
Phylogenic analysis of Atg3 proteins from different organisms showed that T. vaginalis was not in a close evolutionary relationship with any other protozoan. The expression of TvAtg3 was upregulated in the late-stationary phase of GR culture, implying its involvement in autophagy. Immunofluorescence analysis revealed a much higher TvAtg3 fluorescent intensity located on the round and/or linear structures close to the nucleus. Silencing Tvatg3 expression suppressed GR-induced TvAtg8 expression and autophagic vacuoles formation.

Conclusions:
These findings suggest the potential role of TvAtg3 in T. vaginalis autophagy and enhance our understanding of the autophagy regulatory network in the deep-branching eukaryotes.
Relation of Glycosylated Hemoglobin and Obesity Indices with Diastolic Dysfunction in Participants with Type 2 Diabetes Mellitus
Authors: Patil Virendra Chandrashekhar , Avhad Aniket Bhaskar 
Published: September 2020

Background:
Diabetes is an important risk factor of cardiomyopathy which can eventually lead to acute or chronic heart failure. Many factors such as obesity, hyperglycemia, suboptimal glycemic control, and hyperlipidemia predispose as well as aggravate long-term complications in diabetes mellitus (DM).

Aim:
The present study was conducted to assess the relation of glycosylated hemoglobin (HbA1c) and obesity indices (body mass index [BMI], waist circumference [WC]) with diastolic dysfunction in participants with type 2 DM (T2DM).

Methods:
This was a cross-sectional study conducted at the teaching hospital during a 1-year period. All 100 consecutive T2DM participants were investigated for HbA1c, blood sugars and lipid profile parameters, and echocardiography. Standardized transthoracic echocardiographic examination was performed (American Society of Echocardiography) using Vivid S6 ultrasound machine with 4–5 MHz probe. Left ventricular diastolic dysfunction (LVDD) was labeled if 3 or more of these variables were abnormal: “Septal e <7 cm/s, lateral e <10 cm/s, E/e' >14, LA volume index >34 mL/m2, and Peak TR velocity >2.8 m/s.”

Results:
Out of the total 100 diabetics, 37% had diastolic dysfunction (Grade I: 30 [81.08%] and Grade II: 7 [18.91%]). The peak early transmitral filling wave velocity (E) in diabetics with obesity was low as compared to diabetics with normal weight (44 ± 11 cm/s vs. 52 ± 7.5 cm/s). Higher BMI was associated with higher peak late transmitral velocity (A) (61 ± 14 cm/s vs. 38 ± 6.24 cm/s). The mean of E/A ratio was significantly lower in diabetics with obesity. The E/e' ratio was higher in diabetics with obesity (14.8 ± 2.8 vs. 12.86 ± 2.14). The mean of WC was 90.18 ± 6.82 cm in participants of diastolic dysfunction, whereas it was 86.46 ± 6.42 cm in those without dysfunction. Diastolic dysfunction was present in participants with a suboptimal glycemic control, HbA1c ≥ 6.5% (40%), with longer duration of diabetes (62.16%) (P = 0.003). Thus, a higher BMI was associated with higher diastolic dysfunction (P = 0.027).

Conclusions:
The present study reveals burden of LVDD in asymptomatic T2DM participants with its significant association with age, obesity indices (WC and BMI), HbA1c levels, and longer duration of diabetes. This highlights the magnitude of obesity and suboptimal glycemic control that should be considered in the management of cardiac complications in the form of development of diastolic dysfunction. It will benefit in triage for the optimal management of diabetes.
Morphometric Study of Hyoid Bone and its forensic implication
Authors: Journals Europasian 
Published: September 2020

Background: Hyoid bone, the bone of anterior neck is significant in forensic medicine as it presents the sexual dimorphism. Also, the measurement can be quick and easy. This study was conducted with the aim of finding the exact morphometry of hyoid bone and its relationship with sex and height of individual via cadaveric study so that it can aid in forensic investigation as well as archaeological studies.
Methods: This was a cross-sectional study, conducted on 60 hyoid bones (36 male and 24 female) in the Department of Anatomy from 2013 to 2016. Fine dissection was done to get the hyoid bone during the practical of Neck for MBBS and BDS students. The damaged, abnormal and unfused hyoid bones were excluded. Before the dissection, sex and approximate age of the cadaver was recorded. The ethical approval was taken from the department. The 12 major anthropometric measurements were taken on each hyoid bone using digital Vernier Calipers, and electronic weighing machine. The mean, standard deviation were calculated, and t-test was used as a statistical tool to compare the mean, and Karl Pearson’s correlation coefficient was used to see the association. The p-value <.05 was considered significant.
Result: Total of 60 hyoid bones were studied in this study, out of which 36(60%) were male. The average length of all 12 major parameters of the hyoid bone were found to be significantly greater in male than in female. Moreover, the length of the cadaver (height) had significantly correlated with the
Conclusion: All the anthropometric measurements of hyoid bone were significantly greater in males than in females. Moreover, the height of the person had strong positive correlation with the vertical breadth and transverse length of the body of hyoid bone. The anthropometrical parameters of hyoid bone can be used for forensic investigation as well as archeological studies.
Firms’ Economic Reliance to National Markets and the Corporate Provision of Public Goods: Evidence from Corporate Disaster Philanthropy
Authors: Ballesteros Luis 
Published: September 2020

The central goal of this dissertation is to contribute to the understanding of the determinants of nonmarket strategy by multinational enterprises and its consequences for the firm and its stakeholders. I follow an integrative theoretical framework whose cornerstone is the strength of a firm’s economic connection with a country or economic reliance—i.e., the extent to which firms sell, buy, or rent raw materials, final products, or services, or hire human capital to/from a given national market.
From Offshoring to Rightshoring: Focus on the Backshoring Phenomenon
Authors: Bals Lydia , Daum Anika , Tate Wendy 
Published: September 2020

Backshoring has been on the rise, as companies revisit their previous location and governance (make or buy) decisions, relocating business processes, manufacturing and services, which previously had been moved to an offshore or nearshore location, back to the country of origin. This article explores the drivers of this phenomenon and discussed a number of trends such as technological advances (e.g. industry 4.0) as well as closed-loop supply chains. It closes with an outlook on factors influencing the backshoring trend in the near future.
Personal Experiences of Oppression of Women Stereotypes in the Middle East: Both East and West are Guilty
Authors: Abdelzaher Dina M. , Bullough Amanda 
Published: September 2020

Researchers need to isolate their own personal biases if we are to conduct truth – seeking culture research, even though this is difficult. In our study of Afghan and Saudi women on how family and collectivism impact entrepreneurial success/intention, we find that even within MiddleEastern Muslim women there are evident biases on their perceived degree of oppression. We conclude that both easterners and westerners are guilty of wrongfully stereotyping these women as “oppressed”, which can be attributed to poor understanding of social norms that shape their behaviors, which can be regarded as legitimate in the eyes of the so called “oppressee”.
Pandemia Económica por Covid-19
Authors: Orellana Oscar 
Published: September 2020

Pandemia: este vocablo que procede del griego “pan” que significa “todos” y demos que significa “pueblo”, también aplica en la actualidad para uno de los temas más controversiales y significativos que mueven al ser humano y que su incorrecta aplicación, ha sido la causa incluso de la extinción de muchos pueblos a lo largo de la historia. La pandemia económica, que se visualiza como consecuencia del Covid-19 no es la excepción, su magnitud si no se controla puede llevar al mundo a una catástrofe económica sin límites, provocada por shocks de oferta y de demanda incontrolados. ¿Será la intervención del gobierno, la capacidad de producción de los empresarios o bien las decisiones racionales de los consumidores, lo que resuelvan este problema?, desde una perspectiva lineal no es posible, debe ser un problema que se debe abordar desde su dimensión de interacciones complejas entre los factores que participan, incluyendo al ecosistema.
Evaluación del desempeño profesional de los docentes normalistas: calidad, dedicación y permanencia.
Authors: Gómez Heredia Blas Alberto 
Published: September 2020

Este trabajo analiza la realidad que se presenta en la evaluación del desempeño profesional de los maestros del Estado de Chihuahua durante el ciclo escolar 2017-2018, a través de un estudio en las Escuelas Normales, Centros de Actualización del magisterio y Centros de Investigación y Docencia como instituciones de Educación Superior, Formadoras y Actualizadoras de la Entidad Federativa. Se distinguen tres dimensiones de análisis en la investigación: Calidad en el desempeño de la docencia, Dedicación a la Docencia, y Permanencia en las Actividades de la Docencia de sus catedráticos.
Además, se analizan las teorías y modelos contemporáneos acerca de la formación inicial docente para identificar los fundamentos curriculares del Plan de Estudios de Licenciatura en Educación Primaria, 2012. Se fundamentan los resultados de la evaluación de los docentes de una escuela normal y se proponen acciones para elevar los niveles de calidad, dedicación y permanencia en la Docencia para las Licenciaturas de Educación Primaria y Preescolar de la Escuela Normal “Miguel Hidalgo” de Hgo. Del Parral, Chih.
Palabras clave
Desempeño, Calidad, Dedicación y Permanencia.
Abstract
This paper analyses the reality that is presented in the evaluation of the professional performance of the teachers of the State of Chihuahua during the school cycle 2017-2018, through a study in the Normal Schools, Centers of Updating of the Magisterium and Centers of Research and Teaching as institutions of Higher Education, Training and Updating of the Federal Entity. Three dimensions of Analysis Are distinguished in the research: Quality in the performance of the teaching, Dedication to the Teaching, and Permanence in the Activities of the Teaching of his professors.
In Addition, contemporary theories and models about initial teacher training are analyzed to identify the curricular foundations of the Master'S Degree in Primary Education curriculum, 2012. The results of the evaluation of the teachers of a normal school Are based and they propose actions to raise the levels of quality, dedication and permanence in the Teaching for the undergraduates of Primary Education and preschool of the Normal School "Miguel Hidalgo " De Hgo. Del Parral, Chih.

Keywords
Performance, Quality, Dedication and Permanence
Red RIMCI para mejorar la competencia investigadora en estudiantes universitarios en Iberoamérica.
Authors: Lagunes Dominguez Agustin 
Published: September 2020

Este artículo presenta la problemática para desarrollar la competencia investigadora en estudiantes universitarios en Iberoamérica, los antecedentes desde los trabajos de la UNESCO, el proceso de Bolonia y el Espacio Europeo de Educación Superior, hasta nuestros días.
Se realiza un análisis sobre los esfuerzos que se han hecho para desarrollar la competencia investigadora y porque no han funcionado, se presenta a la red RIMCI como una iniciativa para desarrollar esta competencia.
Dentro de los resultados de la red son, la creación de un canal en YouTube, semilleros de investigación y medir las competencias informacionales de los estudiantes universitarios en América Latina.
Palabras clave
Competencia, estudiantes, investigación, red, RIMCI.
Abstract
This article presents the problematic to develop the research competence in university students in Ibero-America, the antecedents from the work of the UNESCO, the process of Bologna and the European area of higher education, until our Days.
An analysis is made on the efforts that have been made to develop the research competition and because they have not worked, it is presented to the RIMCI network as an initiative to develop this competition.
Within the results of the network are, the creation of a YouTube channel, research seedlings and measure the information skills of university students in Latin America.
Keywords
Competition, students, research, network, RIMCI.