bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated expression analysis revealed RUNX2 upregulation in lung squamous cell carcinoma tissues
Authors: Yang Da‐Ping , Lu Hui‐Ping , Chen Gang , Yang Jie , Gao Li , Song Jian‐Hua , Chen Shang‐Wei , Mo Jun‐Xian , Kong Jin‐Liang , Tang Zhong‐Qing , Li Chang‐Bo , Zhou Hua‐Fu , Yang Lin‐Jie 
Published: September 2020

This study aimed to investigate the clinicopathological significance and prospective molecular mechanism of RUNX family transcription factor 2 (RUNX2) in lung squamous cell carcinoma (LUSC). The authors used immunohistochemistry (IHC), RNA‐seq, and microarray data from multi‐platforms to conduct a comprehensive analysis of the clinicopathological significance and molecular mechanism of RUNX2 in the occurrence and development of LUSC. RUNX2 expression was significantly higher in 16 LUSC tissues than in paired non‐cancerous tissues detected by IHC (P  < 0.05). RNA‐seq data from the combination of TCGA and genotype‐tissue expression (GTEx) revealed significantly higher expression of RUNX2 in 502 LUSC samples than in 476 non‐cancer samples. The expression of RUNX2 protein was also significantly higher in pathologic T3‐T4 than in T1‐T2 samples (P  = 0.031). The pooled standardised mean difference (SMD) for RUNX2 was 0.87 (95% CI, 0.58–1.16), including 29 microarrays from GEO and one from ArrayExpress. The co‐expression network of RUNX2 revealed complicated connections between RUNX2 and 45 co‐expressed genes, which were significantly clustered in pathways including ECM‐receptor interaction, focal adhesion, protein digestion and absorption, human papillomavirus infection and PI3K‐Akt signalling pathway. Overexpression of RUNX2 plays an essential role in the clinical progression of LUSC.
Punica granatum Leaf Ethanolic Extract and Ellagic Acid as Inhibitors of Zika Virus Infection
Authors: Acquadro Stefano , Civra Andrea , Cagliero Cecilia , Marengo Arianna , Rittà Massimo , Francese Rachele , Sanna Cinzia , Bertea Cinzia , Sgorbini Barbara , Lembo David , Donalisio Manuela , Rubiolo Patrizia 
Published: September 2020

AbstractZika virus, an arthropod-borne flavivirus, is an emerging healthcare threat worldwide. Zika virus is responsible for severe neurological effects, such as paralytic Guillain-Barrè syndrome, in adults, and also congenital malformations, especially microcephaly. No specific antiviral drugs and vaccines are currently available, and treatments are palliative, but medicinal plants show great potential as natural sources of anti-Zika phytochemicals. This study deals with the investigation of the composition, cytotoxicity, and anti-Zika activity of Punica granatum leaf ethanolic extract, fractions, and phytoconstituents. P. granatum leaves were collected from different areas in Italy and Greece in different seasons. Crude extracts were analyzed and fractionated, and the pure compounds were isolated. The phytochemical and biomolecular fingerprint of the pomegranate leaves was determined. The antiviral activities of the leaf extract, fractions, and compounds were investigated against the MR766 and HPF2013 Zika virus strains in vitro. Both the extract and its fractions were found to be active against Zika virus infection. Of the compounds isolated, ellagic acid showed particular anti-Zika activities, with EC50 values of 30.86 µM for MR766 and 46.23 µM for HPF2013. The mechanism of action was investigated using specific antiviral assays, and it was demonstrated that ellagic acid was primarily active as it prevented Zika virus infection and was able to significantly reduce Zika virus progeny production. Our data demonstrate the anti-Zika activity of pomegranate leaf extract and ellagic acid for the first time. These findings identify ellagic acid as a possible anti-Zika candidate compound that can be used for preventive and therapeutic interventions.
Krebstherapie – 68Ga-PSMA-PET/CT beim rezidivierten Prostatakarzinom richtungweisend und kosteneffektiv
Authors: Krome Susanne 
Published: September 2020

Schwenck J et al. Intention-to-Treat Analysis of 68Ga-PSMA and 11C-Choline PET/CT Versus CT for Prostate Cancer Recurrence After Surgery. J Nucl Med 2019; 60: 1359–1365
15–40 % der Patienten mit einem Prostatakarzinom erleiden postoperativ ein biochemisches Rezidiv. In der retrospektiven Analyse beeinflussten die Bildgebungsverfahren die Häufigkeit einer richtigen Therapiewahl. Die Autoren empfehlen die 68Ga-PSMA-PET/CT, die die höchste Genauigkeit aufwies. Unter Berücksichtigung der Kosten für inadäquate Behandlungen entstünden keine ökonomischen Nachteile.
Fachärzte bevorzugen Privatpatienten – Gesetzlich Versicherte warten mehr als doppelt so lange auf Termine wie Privatpatienten
Authors:   RWI – Leibniz-Institut für Wirtschaftsforschung
Published: September 2020

Werbeck A, Wübker A, Ziebarth NR. Cream Skimming by Health Care Providers and Inequality in Health Care Access: Evidence From a Randomized Field Experiment. Ruhr Economic Papers #846. DOI: 10.4419/86788981
Immer wieder heißt es, dass Privatpatientinnen und Privatpatienten in Deutschland schneller einen Arzttermin bekämen als gesetzlich Versicherte. Wissenschaftliche Erkenntnisse gab es dazu bislang jedoch kaum. Eine Studie des RWI – Leibniz-Institut für Wirtschaftsforschung und der Cornell University bestätigt nun den Verdacht.
Can the Wall Shear Stress Values of Left Internal Mammary Artery Grafts during the Perioperative Period Reflect the One-Year Patency?
Authors: Zhu Lan , Pan Zilai , Li Zehang , Chang Yunxiao , Zhu Yunpeng , Yan Fuhua , Tu Shengxian , Yang Wenjie 
Published: September 2020

Abstract
Purpose The left internal mammary artery (LIMA) is the preferred graft for coronary artery bypass grafting, but the reasoning for LIMA occlusion is unclear. We sought to examine whether the wall shear stress (WSS) values of LIMA grafts during the perioperative period reflected the 1-year patency by using combining computational fluid dynamics (CFD) and coronary computed tomography angiography (CCTA) images.
Methods CCTA was performed in 233 patients with LIMA graft perioperatively and 1 year later from October 2014 to May 2017. LIMA occlusion was detected in six patients at the 1-year follow-up CCTA. Two patients were excluded due to poor imaging quality. The remaining four patients were enrolled as occlusive (OCC) group, and eight patients with patent LIMA were recruited as patent (PAT) group. The WSS values of LIMA during perioperative period were calculated. LIMA graft was artificially divided into three even segments, proximal (pLIMA), middle (mLIMA) and distal (dLIMA) segments. The independent samples t-test and the Student–Newman–Keuls test were used.
Results The WSS values of dLIMA were significantly higher in the PAT group than in the OCC group (4.43 vs. 2.56, p < 0.05). The WSS values of dLIMA in the PAT group were significantly higher than pLIMA, which was absent in the OCC group.
Conclusions A higher WSS value of the distal segment of LIMA and a higher WSS value of the distal segment compared with the proximal segment of LIMA in the PAT were observed; this tendency might be helpful in predicting the 1-year patency of LIMA.
The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement
Authors: Macías Á. Millán 
Published: September 2020

AbstractThe new pandemic disease COVID-19 has wreaked havoc worldwide. Its infectious agent, SARS-CoV-2, uses two key human enzymes called angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) to invade body cells. The first one is encoded by the ACE2 gene and the second by the TMPRSS2 gene. Both have an outstanding expression of RNA and proteins in the small intestine compared with other tissues. This prominent location may be related to the main entry route of SARS-CoV-2 into the organism. In the process of infection, two other genes can play a fundamental role: NOS2, which expresses inducible nitric oxide synthase (iNOS), and AOC1, which encodes diamine oxidase (DAO). Both also highlight in the small intestine and are involved in polyamine metabolism. These biogenic amines are important for viral replication, being enhanced when NOS2 and AOC1 genes are downregulated. In addition, NOS2 shows a negative correlation with ACE2 and TMPRSS2, while nondegraded histamine by DAO can lead to an upregulation of both genes on which the virus depends. Taken together, these data suggest that inhibition or underexpression of NOS2 and AOC1 determines the susceptibility to get sick, increasing the risk of infection. On the other hand, a therapeutic approach to the disease could be made with homeopathic medicines. Experiments show the remedies' ability to stimulate gene and protein expression, but a correlation between the symptoms of each drug and these expressions has not yet been established. Here an analysis of the pathogenesis of Silicea terra and Arsenicum album supported on the scientific literature is done. The objective is to propose a theory about their relationship with key genes whose protein expressed in deficiency can give rise to the chain of events that imbalance the internal environment (homeostasis) and allow the development of symptoms. Silicea seems to be related to NOS2 (gene)/iNOS (protein) and Arsenicum with AOC1 (gene)/DAO (protein), being necessary to carry out studies to corroborate these links. Therefore, the aim of this article is to show the importance of NOS2 and AOC1 genes in the development of COVID-19 and to propose a line of investigation to evaluate if homeopathy can improve their protein expression.
A Web Application for Adrenal Incidentaloma Identification, Tracking, and Management Using Machine Learning
Authors: Bala Wasif , Steinkamp Jackson , Feeney Timothy , Gupta Avneesh , Sharma Abhinav , Kantrowitz Jake , Cordella Nicholas , Moses James , Drake Frederick Thurston 
Published: September 2020

Abstract
Background Incidental radiographic findings, such as adrenal nodules, are commonly identified in imaging studies and documented in radiology reports. However, patients with such findings frequently do not receive appropriate follow-up, partially due to the lack of tools for the management of such findings and the time required to maintain up-to-date lists. Natural language processing (NLP) is capable of extracting information from free-text clinical documents and could provide the basis for software solutions that do not require changes to clinical workflows.
Objectives In this manuscript we present (1) a machine learning algorithm we trained to identify radiology reports documenting the presence of a newly discovered adrenal incidentaloma, and (2) the web application and results database we developed to manage these clinical findings.
Methods We manually annotated a training corpus of 4,090 radiology reports from across our institution with a binary label indicating whether or not a report contains a newly discovered adrenal incidentaloma. We trained a convolutional neural network to perform this text classification task. Over the NLP backbone we built a web application that allows users to coordinate clinical management of adrenal incidentalomas in real time.
Results The annotated dataset included 404 positive (9.9%) and 3,686 (90.1%) negative reports. Our model achieved a sensitivity of 92.9% (95% confidence interval: 80.9–97.5%), a positive predictive value of 83.0% (69.9–91.1)%, a specificity of 97.8% (95.8–98.9)%, and an F1 score of 87.6%. We developed a front-end web application based on the model's output.
Conclusion Developing an NLP-enabled custom web application for tracking and management of high-risk adrenal incidentalomas is feasible in a resource constrained, safety net hospital. Such applications can be used by an institution's quality department or its primary care providers and can easily be generalized to other types of clinical findings.
Over-Representation of Recessive Osteogenesis Imperfecta in Asian Indian Children
Authors: Panigrahi Inusha , Qureshi Yousaf , Kornak Uwe 
Published: September 2020

AbstractSeveral genes are implicated in the etiology of early onset osteogenesis imperfecta (OI). The various genes causing severe OI include WNT1, SERPINF1, P3H1, CREB3L1, and CRTAP, although glycine substitutions in COL1A1chains have also been predicted to cause perinatal lethal OI . Patients with early onset OI present decreased mobility, recurrent rib fractures, bony deformities, and chest infections that lead to an early death. We reported our experience in children with OI in Asian Indian families, which includes two patients with SERPINF1 pathogenic variants; and another two patients with severe OI and antenatal fractures caused by pathogenic variants in the CRTAP gene, identified by next generation sequencing (NGS). For one affected fetus, medical termination of pregnancy was done. The other baby was started on zoledronate therapy just after birth and is now 3 years old. Prenatal diagnosis was subsequently done on chorionic villus sample in the latter family.
Social markers of a pandemic: modeling the association between cultural norms and COVID-19 spread data
Authors: Kapitány-Fövény Máté , Sulyok Mihály 
Published: September 2020

AbstractWhile cross-national differences of the epidemic curves of COVID-19 become evident, social markers of such variability are still unexplored. In order to investigate how certain social norms may underlie the heterogeneity of the spread of infections, global social data (including cultural values, indices of prosperity, and government effectiveness) and covariates (such as climate zone, economic indicator, and healthcare access and quality) of early transmission dynamics of COVID-19 were collected. Model-based clustering and random forest regression analysis were applied to identify distinct groups of societies and explore predictors of COVID-19 doubling time. Clustering revealed four groups: (1) reserved; (2) drifting; (3) assertive; and (4) compliant societies. Compliant societies from dry climate zones showed the highest doubling times in spite of increased population densities. Most relevant predictors of doubling time were population density, freedom of assembly and association, and agency, underlining the importance of social factors in the hetereogeneity of COVID-19 transmission rates. Our cluster typology might contribute to the explanation of cross-national variability in early transmission dynamics of highly infectious diseases.
Shear-assisted grain coarsening in colloidal polycrystals
Authors: Li Wei , Peng Yi , Zhang Yongjun , Still Tim , Yodh A. G. , Han Yilong 
Published: September 2020

Significance
Grain growth and grain-boundary motions during shear play key roles in polycrystal annealing. Notably, complex interactions between neighboring grains give rise to nontrivial grain-boundary kinetics that are not well understood, in part because electron microscopy cannot dynamically track atoms. Here, we observe grain-growth behaviors and elucidate kinetics from experiments with colloidal polycrystals that resolve single-particle motions; the observations reveal shear-coupled grain-boundary migration, grain rotation via emission of dislocations across the grain, melting-point shifts for different lattice orientations, and melting–recrystallization phenomena, which provide a mechanism for unexplained dynamic abnormal grain growth. These fundamental findings are critical results for understanding and processing polycrystalline materials.
Ethnic labeling among pupils with migration backgrounds
Authors: van de Weerd Pomme 
Published: September 2020

Abstract
This paper analyzes ethnic self-labeling among pupils of a secondary school in Venlo, the Netherlands.
Pupils with migration backgrounds, born in the Netherlands, referred to themselves as ‘Moroccan’, ‘Turk’ or ‘foreigner’,
and to others as ‘Dutch’. Ascription to these ethnic categories is often understood as an expression of national
(un)belonging. Based on nine months of linguistic ethnographic fieldwork, I argue that ethnic labels functioned to
manage everyday interpersonal social relations and did not necessarily express feelings of (un)belonging to the nation.
Rather, pupils used ethnic labels to associate social personae with particular styles and behaviors and to construct
local social hierarchies. The paper contributes to the investigation of ethnic labels as signs with locally contingent
meanings, which nevertheless retain indexical links with wider discourses about social categories and belonging. It
furthermore emphasizes the necessity of investigating the local meanings of ethnic categories.
Exhaustivity and bare numeral phrases in Mandarin
Authors: Tsai Cheng-Yu Edwin 
Published: September 2020

AbstractA well-known generalization about bare numeral phrases (BNPs) in Mandarin is that they tend to require the existential verbyou‘have’ when in subject position, but there are some notable exceptions. This paper concentrates on the data cited byLi (1998)and proposes anExhaustivity Conditionaccording to which a subject BNP is felicitous if and only if it is interpreted exhaustively. It is shown how this condition generalizes to all the constructions under discussion, while at the same time they each belong to a particular type of quantificational construction or another (cumulativity, scalar focus, sufficiency, or conditional). I argue that the close relation between Mandarin subject BNPs and exhaustivity not only explains the restricted distribution of the former but also enables us to account for their so-called quantity readings in terms of exhaustive interpretation. Comparisons of the proposal with previous approaches will also be discussed.
Agency and communion in sexual abuse survivors’ narratives
Authors: Wilinsky Charlotte L. , McCabe Allyssa 
Published: September 2020

Abstract
This study uses a form of narrative analysis to examine a sample of sexual abuse survivors’ impact statements
(n = 117) given in court at the sentencing of the former USA Gymnastics Olympic team doctor, Larry Nassar.
Narrative analysis allows for prioritization of the victim’s perspective. Statements are analyzed using themes of agency and
communion (McAdams et al., 1996) and ineffectiveness and alienation (McCabe & Dinh, 2016). Inclusion of ineffectiveness and alienation extends the work of
McAdams, which began in the 1990s. Findings show that ineffectiveness and communion are positively correlated, as are
ineffectiveness and alienation. Age and agency are also positively correlated such that older victims readily express themes of
personal power and achievement. Agency and alienation are significantly more common in the statements than ineffectiveness. These
findings suggest that participants’ sense of communion is particularly harmed by their victimization, and that impact statements
have agentic-based and communion-based functions.
Semiclassical p-branes in hyperbolic space
Authors: de León Ardón Rodrigo 
Published: September 2020

Abstract
The one-loop effects to the Dirac action of p-branes in a hyperbolic background from the path integral and the solution of the Wheeler–DeWitt equation are analysed. The objective of comparing the equivalent quantization procedures is to study in detail the validity of the semiclassical approximation and divergences associated to one-loop corrections. This is in line with a bottom-up approach to holographic Wilson loops. We employ the heat kernel regularization method for both quantization procedures and we study in great detail one-loop corrections to geodesics in a two-dimensional hyperbolic space and semi-spheres in a three-dimensional hyperbolic space. We show that the divergences, given by the high energy expansion of the heat kernel, can be classified by their compatibility with the semiclassical approximation and geometric nature.
Using a ‘vector rotation’ technique and ‘parallel geometry’ utility to calculate the equivalent dose rate from a patient undergoing nuclear medicine procedures
Authors: Phuong Thao Nguyen Thi , Dubois Pedro Arce , Trung Nguyen Thien , Duy Nguyen Khanh , Son Nguyen Dong 
Published: September 2020

Abstract

A dose calculation for a person who has been in contact with a patient undergoing Nuclear medicine procedures can be performed by using Merged Phantom Tool (MPT). In this study, we are upgrading the MPT to help users easily merge phantoms at any axis and with any angle using the “vector rotation” technique. The segmented structure information of the contact’s phantom is also included in the calculation using the GEANT4 “parallel geometry” utility. The calculation is applied to a case of a male cancer patient lying on a bed who has used I-131, and a caregiver standing beside the patient. The equivalent dose to the thyroid of the caregiver is calculated at 0.3, 0.5, 0.8 and 1m away from the patient, as the caregiver is standing near the patient’s abdomen, chest and neck area. The results show that the dose to the thyroid of the contact greatly depends on his standing position and that there are clear differences between the results calculated with the point source and those calculated with the patient source. In summary, using activity distributions in the patient’s body as well as the right communication circumstance helps to calculate the optimal dose for people who have been in contact with patients.
A numerical study of the influence of crystal plasticity modeling parameters on the plastic anisotropy of rolled aluminum sheet
Authors: Kasemer M , Falkinger G , Roters F 
Published: September 2020

Abstract
The production of stamped parts from rolled aluminum sheets requires different tempers and different thermal routes. While the slip and hardening behavior of the alloy strongly depends on the temper and the process temperature, the crystallographic texture remains largely static. Although the plastic anisotropy of rolled sheet is largely a function of the crystallographic texture, a dependency of plastic anisotropy on the temper has been reported for 6xxx series alloys, indicating that slip and hardening behavior have some influence. A systematic investigation of the effect of the slip and hardening behavior on the plastic anisotropy, however, does not exist. In this study, a crystal plasticity fast Fourier transform framework is utilized to predict the r-values, a common measure for plastic anisotropy, of two widely used commercial aluminum alloys possessing different crystallographic textures, AA6016 and AA5182. To investigate the sensitivity of the r-values to changes in the modeling parameters, a suite of simulations is performed in which the modeling parameters are systematically changed, and the resulting changes to the predicted r-values are calculated. Furthermore, numerical parameters, such as the level of discretization and the number of simulated grains are studied. Results indicate that the predicted r-value is less dependent on changes to crystal plasticity modeling parameters than to the initial crystallographic texture. Resulting trends are discussed.