bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in care for children undergoing the Fontan operation for hypoplastic left heart syndrome
Authors: Eckhauser Aaron W. , Van Rompay Maria I. , Ravishankar Chitra , Newburger Jane W. , Ram Kumar S. , Pizarro Christian , Ghanayem Nancy , Trachtenberg Felicia L. , Burns Kristin M. , Hill Garick D. , Atz Andrew M. , Hamstra Michelle S. , Mazwi Mjaye , Park Patsy , Richmond Marc E. , Wolf Michael , Zampi Jeffrey D. , Jacobs Jeffrey P. , Minich L. LuAnn ,   for the Pediatric Heart Network Investigators
Published: November 2019

AbstractBackground:The Single Ventricle Reconstruction Trial randomised neonates with hypoplastic left heart syndrome to a shunt strategy but otherwise retained standard of care. We aimed to describe centre-level practice variation at Fontan completion.Methods:Centre-level data are reported as median or median frequency across all centres and range of medians or frequencies across centres. Classification and regression tree analysis assessed the association of centre-level factors with length of stay and percentage of patients with prolonged pleural effusion (>7 days).Results:The median Fontan age (14 centres, 320 patients) was 3.1 years (range from 1.7 to 3.9), and the weight-for-age z-score was −0.56 (−1.35 + 0.44). Extra-cardiac Fontans were performed in 79% (4–100%) of patients at the 13 centres performing this procedure; lateral tunnels were performed in 32% (3–100%) at the 11 centres performing it. Deep hypothermic circulatory arrest (nine centres) ranged from 6 to 100%. Major complications occurred in 17% (7–33%). The length of stay was 9.5 days (9–12); 15% (6–33%) had prolonged pleural effusion. Centres with fewer patients (<6%) with prolonged pleural effusion and fewer (<41%) complications had a shorter length of stay (<10 days; sensitivity 1.0; specificity 0.71; area under the curve 0.96). Avoiding deep hypothermic circulatory arrest and higher weight-for-age z-score were associated with a lower percentage of patients with prolonged effusions (<9.5%; sensitivity 1.0; specificity = 0.86; area under the curve 0.98).Conclusions:Fontan perioperative practices varied widely among study centres. Strategies to decrease the duration of pleural effusion and minimise complications may decrease the length of stay. Further research regarding deep hypothermic circulatory arrest is needed to understand its association with prolonged pleural effusion.
The Art and Science of Economic Explanation: Introduction to the Special Issue in Honor of Yoram Barzel
Authors: Candela Rosolino A. , Piano Ennio E. 
Published: November 2019

AbstractThis introduction to the special issue in honor of Professor Yoram Barzel provides an overview of his scholarship and a summary of the contributions to this special issue. Each contribution advances or elaborates upon major themes in Barzel's theoretical and applied work on property rights, transaction costs, and political economy. The contributions fall into three categories: an examination of the foundations and implications of the ‘Barzelian’ method for social scientific analysis; Barzel's economics of property rights and transaction costs to historical case studies; and advances to Barzel's theory of the state, which includes an analysis of the origins of democracy and the rule of law.
Reducing the Length of the Multidimensional Scale of Perceived Social	Support
Authors: Porter Ben , Kolaja Claire A. , Powell Teresa M. , Pflieger Jacqueline C. , Stander Valerie A. , Armenta Richard F. 
Published: November 2019

Abstract. The Multidimensional Scale of Perceived Social Support (MSPSS) is a widely used 12-item measure that assesses perceived social support from three sources: friends, family, and significant others. Previously published psychometric properties indicate that a shorter version of this scale may adequately assess perceived social support and reduce participant burden. The current studies sought to develop such a reduced scale across two studies. Study 1 examined a sample of spouses of US military personnel ( N = 5,436) randomly separated into exploratory and confirmatory samples. In the exploratory sample, we developed a 6-item reduced MSPSS using multidimensional item response theory. In the confirmatory sample, the reduced MSPSS fit the hypothesized structure and was highly correlated with the full MSPSS. Study 2 administered the full and reduced MSPSS separately within a sample of undergraduate students ( N = 188). The reduced MSPSS had high correlations with the full measure ( r = .90) and fit the hypothesized factor structure. Across both studies, correlations with related constructs were similar between the reduced and full MSPSS, demonstrating almost no loss of construct validity. Overall, the reduced MSPSS captured perceived social support with little loss of information. This reduced scale may be useful for minimizing survey length and participant burden.
Validating the Resource-Management Inventory (ReMI)
Authors: Waldeyer Julia , Fleischer Jens , Wirth Joachim , Leutner Detlev 
Published: November 2019

Abstract. There is substantial evidence that students in higher education who have sophisticated resource-management skills are more successful in their studies. Nevertheless, research shows that students are often not adequately prepared to use resource-management strategies effectively. It is thus crucial to screen and identify students who are at risk of poor resource management (and consequently, reduced academic achievement) to provide them with appropriate support. For this purpose, we extend the validation of a situational-judgment-based instrument called Resource-Management Inventory (ReMI), which assesses resource-management competency (including knowledge of resource-management strategies and the self-reported ability to use this knowledge in learning situations). We evaluated the ReMI regarding factor structure, measurement invariance, and its impact on academic achievement in different study domains in a sample of German first-year students ( N = 380). The results confirm the five-factor structure that has been found in a previous study and indicate strong measurement invariance. Furthermore, taking cognitive covariates into account, the results confirm that the ReMI can predict students’ grades incrementally. Finally, a multi-group analysis shows that the findings can be generalized across different study domains. Overall, we provide evidence for a valid and efficient instrument for the assessment of resource-management competency in higher education.
Convective Precipitation Efficiency Observed in the Tropics
Authors: Narsey Sugata , Jakob Christian , Singh Martin S. , Bergemann Martin , Louf Valentin , Protat Alain , Williams Christopher 
Published: November 2019

AbstractPrecipitation efficiency refers to the fraction of condensate in the atmosphere that reaches the surface as precipitation. A high‐quality data set of radar‐estimated precipitation rates and convective scale vertical velocity near Darwin, Australia, is used to construct the first estimate of precipitation efficiency at convective scales for a long record of observations in the tropics. It is found that precipitation efficiency increases with precipitation rate and midtropospheric humidity and decreases with increasing convective available potential energy and surface temperature. Precipitation efficiency is largest under moist monsoonal conditions and smallest during monsoon break periods, which are characterized by a drier free troposphere. However, these differences in efficiency do not translate to differences in the instantaneous precipitation rate across the synoptic regimes because of a compensating change in the net condensation rate. This is driven by variations in cloud updraft velocity, which is larger in drier environments than in moist environments.
Seismic Evidence of Magmatic Rifting in the Offshore Taupo Volcanic Zone, New Zealand
Authors: Gase Andrew C. , Van Avendonk Harm J. A. , Bangs Nathan L. , Luckie Thomas W. , Barker Daniel H. N. , Henrys Stuart A. , Bassett Dan , Okaya David A. , Jacobs Katrina M. , Kodaira Shuichi , Fujie Gou , Arnulf Adrien F. , Yamamoto Yojiro 
Published: November 2019

AbstractRelationships between extensional tectonics and magmatism are ubiquitous in continental rifts and oceanic spreading centers. Yet few studies document interactions between extensional faults and mantle melts in volcanic arcs. We constrain the crustal structure of the extensional offshore Taupo Volcanic Zone (TVZ) from a marine multichannel and wide‐angle seismic experiment. The TVZ crust thins from >26 km to ∼18–19 km across ∼50 km in the Bay of Plenty. Elevated P wave velocities in the lower crust indicate mafic additions. Magmatic sills between 4‐ and 15‐km depth lie beneath listric normal faults in a ∼40‐km‐wide active rift zone. P wave velocities in the middle and upper crust along the arc front are ∼0.3–0.5 km/s slower than in the adjacent crust, indicating a possible thermal anomaly imparted by heat from magmatic intrusions. We propose that rifting in the offshore TVZ is partially compensated by intrusions and assisted by thermal weakening of the lithosphere.
Western Northern Luzon Isotopic Evidence of Transition From Proto‐South China Sea to South China Sea Fossil Ridge Subduction
Authors: Liu Hai‐Quan , Yumul Graciano P. , Dimalanta Carla B. , Queaño Karlo , Xia Xiao‐Ping , Peng Tou‐Ping , Lan Jiang‐Bo , Xu Yi‐Gang , Yan Yi , Guotana Juan Miguel R. , Olfindo Valerie Shayne 
Published: November 2019

AbstractTemporal geochemical comparisons are conducted for representative magmatism from western Northern Luzon to reconstruct the Cenozoic tectonics. Oligo‐Pleistocene magmas from western Northern Luzon display elemental and Sr‐Nd‐Hf‐Pb‐O isotope geochemistry similar to intraoceanic arc magmatism, consistent with derivation from the mantle wedge, coupled with fractional crystallization. Specifically, the Oligo‐Miocene (~26.8–15.6 Ma) Central Cordillera diorite complex samples exhibit a negative correlation between Sr‐Nd isotopes, consistent with mantle metasomatism by fluids/melts released from pelagic sediments. The Mio‐Pleistocene samples (<~9 Ma) exhibit consistent 87Sr/86Sr ratios with variable εNd and partially overlap with those of Scarborough seamount basalts, consistent with mantle metasomatism by fluids/melts released from the Scarborough seamount basalts, which are being subducted beneath Northern Luzon with the South China Sea fossil ridge. Temporal changes in Sr‐Nd‐Hf‐Pb isotopes are also observed for the Taiwan‐Luzon arc magmatism. The Oligo‐Miocene (>~9 Ma) magmatism exhibit intraoceanic arc isotopic signatures, suggestive of a chemical imprint from subducted pelagic sediments. The Mio‐Pleistocene (<~9 Ma) lavas display enriched mantle‐type isotope compositions, consistent with an input of terrigenous sediment in the mantle. The temporal variations in Sr‐Nd‐Hf‐Pb isotopes for the Taiwan‐Luzon magmatism, combined with paleomagnetic evidence, mirror a transition from the Proto‐South China Sea to the South China Sea fossil ridge subduction beneath western Northern Luzon at ~9 Ma. In addition, this study also highlights the importance of relatively enriched components in the lower plate in the maturation of overriding juvenile oceanic crust in an arc‐continent collision system.
Hydrogeological Modeling and Water Resources Management: Improving the Link Between Data, Prediction, and Decision Making
Authors: Harken Bradley , Chang Ching‐Fu , Dietrich Peter , Kalbacher Thomas , Rubin Yoram 
Published: November 2019

AbstractA risk‐based decision‐making mechanism capable of accounting for uncertainty regarding local conditions is crucial to water resources management, regulation, and policy making. Despite the great potential of hydrogeological models in supporting water resources decisions, challenges remain due to the many sources of uncertainty as well as making and communicating decisions mindful of this uncertainty. This paper presents a framework that utilizes statistical hypothesis testing and an integrated approach to the planning of site characterization, modeling prediction, and decision making. Benefits of this framework include aggregated uncertainty quantification and risk evaluation, simplified communication of risk between stakeholders, and improved defensibility of decisions. The framework acknowledges that obtaining absolute certainty in decision making is impossible; rather, the framework provides a systematic way to make decisions in light of uncertainty and determine the amount of information required. In this manner, quantitative evaluation of a field campaign design is possible before data are collected, beginning from any knowledge state, which can be updated as more information becomes available. We discuss the limitations of this approach by the types of uncertainty that can be recognized and make suggestions for addressing the rest. This paper presents the framework in general and then demonstrates its application in a synthetic case study. Results indicate that the effectiveness of field campaigns depends not only on the environmental performance metric being predicted but also on the threshold value in decision‐making processes. The findings also demonstrate that improved parameter estimation does not necessarily lead to better decision making, thus reemphasizing the need for goal‐oriented characterization.
Microglial regional heterogeneity and its role in the brain
Authors: Tan Yun-Long , Yuan Yi , Tian Li 
Published: November 2019

AbstractMicroglia have been recently shown to manifest a very interesting phenotypical heterogeneity across different regions in the mammalian central nervous system (CNS). However, the underlying mechanism and functional meaning of this phenomenon are currently unclear. Baseline diversities of adult microglia in their cell number, cellular and subcellular structures, molecular signature as well as relevant functions have been discovered. But recent transcriptomic studies using bulk RNAseq and single-cell RNAseq have produced conflicting results on region-specific signatures of microglia. It is highly speculative whether such spatial heterogeneity contributes to varying sensitivities of individual microglia to the same physiological and pathological signals in different CNS regions, and hence underlie their functional relevance for CNS disease development. This review aims to thoroughly summarize up-to-date knowledge on this specific topic and provide some insights on the potential underlying mechanisms, starting from microgliogenesis. Understanding regional heterogeneity of microglia in the context of their diverse neighboring neurons and other glia may provide an important clue for future development of innovative therapies for neuropsychiatric disorders.
Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation
Authors: Lefort Sylvain , Tan Susanna , Balani Sneha , Rafn Bo , Pellacani Davide , Hirst Martin , Sorensen Poul H. , Eaves Connie J. 
Published: November 2019

AbstractHigh YAP activity is associated with poor prognosis human breast cancers, but its role during the initial stage of mammary cell transformation is unknown. To address this question, we designed experiments that exploit the ability of KRASG12D-transduced subsets of freshly isolated normal human mammary cells to form invasive tumors rapidly and efficiently when transplanted into immunodeficient mice. Initial examination of the newly developing tumors thus generated revealed a consistent marked loss of nuclear YAP, independent of the initial primary human mammary cell type transduced. Conversely, co-transduction of the same subsets of primary human mammary cells with KRASG12D plus the constitutively active YAPS127A prevented tumor formation. These findings contrast with the enhanced display of transformed properties obtained when the immortalized, but non-tumorigenic MCF10A cells are transduced just with YAPS127A. In addition, we show that YAPS127A-transduction of the human MDA-MB-231 breast cancer cell line (that carry a similar KRAS mutation) enhances their metastatic activity in vivo. We also discover that the KRASG12D-induced early loss of YAP in primary human mammary cells is associated with their induced secretion of amphiregulin. Collectively, these findings suggest that YAP can differentially affect the acquisition of malignant properties by human mammary cells at different stages of their transformation.
Overexpressed miR-200a promotes bladder cancer invasion through direct regulating Dicer/miR-16/JNK2/MMP-2 axis
Authors: Yang Rui , Xu Jiheng , Hua Xiaohui , Tian Zhongxian , Xie Qipeng , Li Jingxia , Jiang Guosong , Cohen Mitchell , Sun Hong , Huang Chuanshu 
Published: November 2019

AbstractInvasive bladder cancer (BC) is one of the most lethal malignant urological tumors. Although miR-200a has been reported as an onco-miRNA that targets the PTEN gene in endometrioid carcinoma, its biological significance in BC invasion has been poorly explored. In the current study, we found that miR-200a was markedly overexpressed in both human BC tissues and BBN-induced muscle-invasive BC tissues. We further showed that miR-200a overexpression specifically promoted human BC cell invasion, but not migration, via transcriptional upregulation of matrix metalloproteinase (MMP)-2. Mechanistic studies indicated that the increased phosphorylation of c-Jun mediated the increasing levels of MMP-2 mRNA transcription. Further investigation revealed that Dicer was decreased in miR-200a overexpressed BC cells; this resulted in inhibition of miR-16 maturation and consequently led to increased JNK2 protein translation and c-Jun activation. Taken together, the studies here showed that miR-200a overexpression inhibited Dicer expression, in turn, resulted in inhibition of miR-16 maturation, leading to upregulation of JNK2 expression, c-Jun phosphorylation, MMP-2 transcription and, ultimately, BC invasion. Collectively, these results demonstrate that miR-200a is an onco-miRNA that is a positive regulator for BC invasion. This finding could be very useful in the ongoing development of new strategies to treat invasive BC patients.
Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer
Authors: Lv Yaping , Cang Wei , Li Quanfu , Liao Xiaodong , Zhan Mengna , Deng Huayun , Li Shengze , Jin Wei , Pang Zhi , Qiu Xingdi , Zhao Kewen , Chen Guoqiang , Qiu Lihua , Huang Lei 
Published: November 2019

AbstractCancer stem cells (CSCs) are often enriched after chemotherapy and contribute to tumor relapse. While epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely used for the treatment of diverse types of cancer, whether EGFR-TKIs are effective against chemoresistant CSCs in cervical cancer is largely unknown. Here, we reveal that EGFR correlates with reduced disease-free survival in cervical cancer patients with chemotherapy. Erlotinib, an EGFR-TKI, effectively impedes CSCs enrichment in paclitaxel-resistant cells through inhibiting IL-6. In this context, MUC1 induces CSCs enrichment in paclitaxel-resistant cells via activation of EGFR, which directly enhances IL-6 transcription through cAMP response element-binding protein (CREB) and glucocorticoid receptor β (GRβ). Treatment with erlotinib sensitizes CSCs to paclitaxel therapy both in vitro and in vivo. More importantly, positive correlations between the expressions of MUC1, EGFR, and IL-6 were found in 20 cervical cancer patients after chemotherapy. Mining TCGA data sets also uncovered the expressions of MUC1-EGFR-IL-6 correlates with poor disease-free survival in chemo-treated cervical cancer patients. Collectively, our work has demonstrated that the MUC1-EGFR-CREB/GRβ axis stimulates IL-6 expression to induce CSCs enrichment and importantly, this effect can be abrogated by erlotinib, uncovering a novel strategy to treat paclitaxel-resistant cervical cancer.
The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma
Authors: Ozyerli-Goknar Ezgi , Sur-Erdem Ilknur , Seker Fidan , Cingöz Ahmet , Kayabolen Alisan , Kahya-Yesil Zeynep , Uyulur Fırat , Gezen Melike , Tolay Nazife , Erman Batu , Gönen Mehmet , Dunford James , Oppermann Udo , Bagci-Onder Tugba 
Published: November 2019

AbstractGlioblastoma Multiforme (GBM) is the most common and aggressive primary brain tumor. Despite recent developments in surgery, chemo- and radio-therapy, a currently poor prognosis of GBM patients highlights an urgent need for novel treatment strategies. TRAIL (TNF Related Apoptosis Inducing Ligand) is a potent anti-cancer agent that can induce apoptosis selectively in cancer cells. GBM cells frequently develop resistance to TRAIL which renders clinical application of TRAIL therapeutics inefficient. In this study, we undertook a chemical screening approach using a library of epigenetic modifier drugs to identify compounds that could augment TRAIL response. We identified the fungal metabolite chaetocin, an inhibitor of histone methyl transferase SUV39H1, as a novel TRAIL sensitizer. Combining low subtoxic doses of chaetocin and TRAIL resulted in very potent and rapid apoptosis of GBM cells. Chaetocin also effectively sensitized GBM cells to further pro-apoptotic agents, such as FasL and BH3 mimetics. Chaetocin mediated apoptosis sensitization was achieved through ROS generation and consequent DNA damage induction that involved P53 activity. Chaetocin induced transcriptomic changes showed induction of antioxidant defense mechanisms and DNA damage response pathways. Heme Oxygenase 1 (HMOX1) was among the top upregulated genes, whose induction was ROS-dependent and HMOX1 depletion enhanced chaetocin mediated TRAIL sensitization. Finally, chaetocin and TRAIL combination treatment revealed efficacy in vivo. Taken together, our results provide a novel role for chaetocin as an apoptosis priming agent and its combination with pro-apoptotic therapies might offer new therapeutic approaches for GBMs.
BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes
Authors: Rigo Antonella , Ferrarini Isacco , Lorenzetto Erika , Darra Elena , Liparulo Irene , Bergamini Christian , Sissa Cinzia , Cavalieri Elisabetta , Vinante Fabrizio 
Published: November 2019

Abstractα-Bisabolol (BSB) is a plant-derived sesquiterpene alcohol able to trigger regulated cell death in transformed cells, while deprived of the general toxicity in several mouse models. Here, we investigated the involvement of lysosomal and mitochondrial compartments in the cytotoxic effects of BSB, with a specific focus on the BH3-only activator protein BID. We found that BSB particularly accumulated in cancer cell lines, displaying a higher amount of lipid rafts as compared to normal blood cells. By means of western blotting and microscopy techniques, we documented rapid BSB-induced BID translocation to lysosomes and mitochondria, both of them becoming dysfunctional. Lysosomal membranes were permeabilized, thus blocking the cytoprotective autophagic flux and provoking cathepsin B leakage into the cytosol. Multiple flow cytometry-based experiments demonstrated the loss of mitochondrial membrane potential due to pore formation across the lipid bilayer. These parallel events converged on neoplastic cell death, an outcome significantly prevented by BID knockdown. Therefore, BSB promoted BID redistribution to the cell death executioner organelles, which in turn activated anti-autophagic and proapoptotic mechanisms. This is an example of how xenohormesis can be exploited to modulate basic cellular programs in cancer.