bluuebunny/crossref_metadata_2025_split huggingface dataset:
P1499 A case of missing left ventricular apex
Authors: Jappar I A , Naing T T , Schumacher-Maurer A , Vineet T , Tang H C 
Published: January 2020

Abstract
Introduction
Isolated left ventricle (LV) apical hypoplasia is a rare congenital anomaly. Echocardiographic diagnosis is challenging if one is not aware of this condition. It can masquerade as LV non-compaction or apical aneurysm. Multimodality imaging with cardiac magnetic resonance (CMR) can be useful to secure the diagnosis.
Case description
An asymptomatic 18-year-old man, with no significant personal or family medical history, was referred to cardiology clinic due to abnormal electrocardiogram (ECG) during routine cardiac screening. ECG showed right axis deviation and delayed precordial QRS-transition. He had excellent effort tolerance during treadmill exercise test (standard Bruce Protocol stage 6). Ambulatory ECG monitoring was within normal limits.
Transthoracic echocardiogram showed a truncated appearance of LV apex with increased apical trabeculation, and bulging right ventricle apex (see image A and B). LV ejection fraction was preserved. The LV appearance was initially thought to be due to foreshortened apical view. A diagnosis of LV non-compaction cardiomyopathy was also inaccurately considered.
He was further evaluated with CMR imaging. The study showed a truncated LV apex and apical insertion of the papillary muscles. RV apex was seen wrapping around the LV (see image C and D). Both the LV and RV function were normal. There was no late gadolinium enhancement (LGE). The morphological abnormalities were consistent with the diagnosis of isolated LV apical hypoplasia.
Patient continued to be physically active and asymptomatic. Follow up CMR five years later showed similar findings of preserved biventricular functions and no fibrosis on LGE imaging.
Discussion
We described a rare case of isolated LV apical hypoplasia with longitudinal clinical and cardiac imaging follow up. Initial diagnosis from transthoracic echocardiogram was elusive, and supportive findings from CMR helped to secure the diagnosis.
In the literature, the clinical presentation ranges from chest pain syndrome, arrhythmias, heart failure or as incidental finding during cardiac imaging, as in our case. It is commonly diagnosed as nonspecific cardiomyopathy when the clinician is not aware of this condition.
Being a rare congenital anomaly, the prognosis is not well established. Our patient remained asymptomatic clinically with preserved biventricular function in his 5 years follow-up.
Abstract P1499 Figure. Echo and CMR imaging
P1503 Aortic root distensibility and stiffness assessed by echocardiography as predictors of coronary artery lesion severity in patients undergoing coronary angiography
Authors: El-Naggar H M , Anwar H S , Helmy H A , Demitry S R 
Published: January 2020

Abstract

Background
Aortic stiffness (AS) and distensibility (AD) have been shown as predictors for cardiovascular morbidity and mortality.
Aim: To assess the relation of aortic stiffness and distensibility using simple two-dimensional (2D) and tissue Doppler imaging (TDI) derived measures with the severity of coronary artery disease (CAD) assessed using the syntax score (SS), evaluating which of these measures has better predictivity for CAD severity.

Methods
We prospectively enrolled 150 individuals who underwent elective coronary angiography for suspected CAD, out of them 29 subjects (19.3%) had normal angiographic findings, while 121 (80.7%) subjects had CAD for whom the SS was calculated. All patients underwent simple 2D and TDI echocardiographic assessment of AS and AD.

Results
Patients with CAD had significantly higher aortic stiffness and elastic modulus and significantly lower aortic distensibility, aortic strain, aortic peak systolic and peak early diastolic velocities compared to those without CAD. Univariate and multivariate logistic regression analysis showed that decreased aortic distensibility, aortic strain, aortic peak early diastolic velocity and increased elastic modulus were predictors for the severity and complexity of CAD. However, along with diabetes, increased aortic stiffness index (&gt; 17.7) was the only independent predictor of CAD severity, carrying twice the odds of having moderate-high syntax score (OR= 2.19, 95% CI= 0.97 – 4.95, p&lt; 0.05).

Conclusion
Aortic stiffness index can be a screening tool for detecting patients with more severe CAD.
Univariate analysis Multivariate analysis Variables Odd’s ratio 95% confidence interval P value Odd’s ratio 95% confidence interval P value Age (years) 0.98 0.94-1.01 0.3 – –- – Sex (male) 1.52 0.58- 3.94 0.3 – –- – Smoking 1.21 0.59- 2.50 0.5 – –- – Diabetes mellitus 5.00 2.29-10.90 0.000 4.99 2.21- 11.31 0.000 Body mass index 0.93 0.83- 1.04 0.2 – –- – ↓↓ Distensibility (≤3.8)* 2.62 1.08- 4.70 0.02 2.01 0.91- 4.46 0.08 ↑↑ Stiffness index (&gt;17.7)* 2.06 0.99- 4.27 0.05 2.19 0.97- 4.95 &lt;0.05 ↑↑ Elastic modulus (&gt;68.7)* 2.22 1.06- 4.64 0.03 2.01 0.91- 4.45 0.08 ↓↓ Aortic strain (≤9.3%)* 2.04 0.97- 4.27 0.05 1.64 0.73- 3.67 0.2 ↓↓ SAo (≤7cm/sec) 1.49 0.71- 3.12 0.2 – –- – ↓↓ EAo (≤9cm/sec) 2.30 1.08- 4.90 0.03 1.80 0.79- 4.10 0.1 Predictors of severity and complexity of CAD
P1507 Early and late morphological changes in the athlete"s heart: a longitudinal cohort study in young elite athletes
Authors: Bjerring A W , Landgraff H E W , Leirstein S , Lihagen M , Skei M , Murbraech K , Brun H , Stokke T M , Haugaa K H , Hallen J , Edvardsen T , Sarvari S I 
Published: January 2020

Abstract

Funding Acknowledgements
South-Eastern Norway Regional Health Authority

OnBehalf
Center for Cardiological Innovation

Background
Recent studies have suggested an initial concentric remodelling in the early development of the athlete’s heart in endurance athletes. However, the development from the early to the fully developed endurance athlete’s heart has not been described in longitudinal studies.

Aims
This study aims to explore the morphological changes occurring in hearts of young endurance athletes transitioning through adolescence.

Methods
Forty-eight cross-country skiers were examined at age 12 (12.1 ± 0.2 years) and then again at age 15 (15.3 ± 0.3 years). Cardiopulmonary exercise test and echocardiography, including 3D acquisitions, was performed in all subjects at both baseline and follow-up.

Results
At follow-up, 31 (65%) of the endurance athletes were still active and 17 (35%) were not. No differences in cardiac morphology were identified at baseline. At 15 years of age, the active endurance athletes had greater VO2 max, 3D indexed left ventricular end-diastolic and end-systolic volumes (Table). Relative wall thickness (RWT) decreased in the active endurance athletes during follow-up (0.35 ± 0.05 to 0.31 ± 0.04, p &lt; 0.001), but not in the former athletes. Four active endurance athletes had RWT above the upper reference values at baseline; at follow up, all had normalized.

Conclusion
After an early concentric remodeling in the 12 years old athletes, those who continued regular endurance training developed eccentric changes with chamber dilatation and a drop in RWT. In contrast, those who ceased endurance training maintained a comparable wall thickness, but did not develop chamber dilatation nor experience a drop in RWT.
Baseline Follow-up Active athletes (n = 31) Former athletes (n = 17) p-value Active athletes (n = 31) Former athletes (n = 17) p-value VO2 max, indexed 65 ± 7 63 ± 7 0.33 62 ± 8 57 ± 6 &lt;0.05 Interventricular septum thickness, mm 7.9 ± 0.8 7.8 ± 1.0 0.54 8.1 ± 1.2 7.8 ± 0.9 0.41 LV end-diastolic diameter, mm/m2 2.1 ± 0.3 2.0 ± 0.3 0.60 3.0 ± 0.2 2.9 ± 0.2 0.34 LV poster wall thickness, mm 7.3 ± 0.9 6.8 ± 0.9 0.07 7.8 ± 1.2 8.1 ± 1.2 0.42 3D LV end-diastolic volume, mL/m2 76 ± 8 74 ± 8 0.89 84 ± 11 79 ± 10 &lt;0.05 3D LV end-systolic volume, mL/m2 33 ± 4 33 ± 4 0.99 36 ± 6 32 ± 3 &lt;0.05 3D LV ejection fraction, % 56 ± 3 56 ± 3 0.93 58 ± 3 59 ± 2 0.52 3D LV Mass/BSA, g/m2 69 ± 7 71 ± 4 0.57 76 ± 11 74 ± 6 0.19 Relative wall thickness 0.35 ± 0.05 0.33 ± 0.05 0.12 0.31 ± 0.04 0.33 ± 0.05 0.05 Data expressed as mean ± SD. P-values calculated using the Student"s paired t-test. Volumes are indexed to body surface area.
P1508 Left ventricular diastolic function plays a different role on mortality depending on the severity of systolic dysfunction in acute heart failure patients with reduced ejection fraction
Authors: Nakamura K , Yamada A , Jinno S , Kato M , Takahashi A , Sugimoto K , Sugimoto K , Ishikawa T , Ozaki Y , Ishii J 
Published: January 2020

Abstract

Background
It remains to be clarified whether clinical significance of left ventricular (LV) diastolic function differs depending on the severity of LV systolic dysfunction in patients with acute heart failure (AHF). The aim of this study was to examine the prognostic role of LV diastolic function in AHF patients with various systolic dysfunction.Methods: We studied consecutive hospitalized AHF patients with LV ejection fraction (LVEF) &lt;50%. The exclusion criteria were as follows: atrial fibrillation, severe mitral regurgitation, and inadequate echo image quality. They underwent echocardiography on admission. The eligible patients (n = 289, 165 males, 76 ± 10 years) were divided into 4 groups based on LVEF and left atrial pressure (LAP) grade estimated as in the ESC guidelines: Group I (LVEF 40-49% (mildly reduced LVEF)/normal LAP, n = 28), II (mildly reduced EF/increased LAP, n = 38), III (LVEF &lt;40% (severely reduced LVEF)/normal LAP, n = 110), and IV (severely reduced LVEF/increased LAP, n = 113). Cardiac death was examined up to 60 months.Results: In total, 58 patients (20%) died because of cardiac events during the follow-up (mean 20 ± 19 months). In patients with mildly reduced LVEF, Group I showed significantly less cardiac death ratio than II (n = 1 vs 10, Group I vs II, p = 0.03). On the other hand, in patients with severely reduced LVEF, there was no significant difference in cardiac death ratio between Group III and IV (n = 23 vs 24, Group III vs IV, p = 0.80). That is, LAP grade was a prognostic marker when the patients had mild LV systolic dysfunction, whereas it did not contribute to the prediction of cardiac mortality when patients showed severely reduced LV systolic function. Group I showed significantly better prognosis than those with severe LV systolic dysfunction regardless of LAP grade (Group III, IV) (Group I vs III, p = 0.04; Group I vs IV, p = 0.04).Conclusions: LV diastolic function may have a different clinical significance depending on the severity of LV systolic dysfunction in AHF patients.
P1526 Updated prevalence of lambls excrescences using the latest three-dimensional transesophageal echocardiography
Authors: Takahashi T , Kusunose K , Hayashi S , Morita S , Torii Y , Hirata Y , Yamao M , Nishio S , Yuichiro O , Abe M , Yamada N , Yamada H , Wakatsuki T , Sata M 
Published: January 2020

Abstract

Background
Lambl’s excrescences (LEs), filiform strands that occur at sites of cardiac valves, have been suggested the cause cryptogenic stroke. The diagnosis is primarily based upon the echocardiographic study, but conventional two-dimensional transthoracic echocardiography has limitation to detect such as small strands. Latest three dimensional-transesophageal echocardiography (3D-TEE) have high-resolution images with many slices, so small structures are able to be clearly visible and detected.

Purpose
The aim of this study was to assess the prevalence of LEs using the latest 3D-TEE images.

Methods
We retrospectively reviewed consecutive 140 patients who underwent 3D-TEE from November 2018 to May 2019. Forty-seven patients were excluded due to unmeasurable, such as mitral valve prolapse, severe aortic stenosis, prosthetic valves and poor-quality images. We carefully evaluated the mitral and aortic valve leaflets in order to find mobile string structure (diameter &lt;1 mm and length 1–20 mm) in each cardiac cycle. Total analyzed images were over 50 slices per one patient.

Results
Among 93 patients, 83 patients (89%) was detected the presence of LEs. No difference in age and gender were found between patients with LEs and patients without LEs. Of the total 83 patients, there were 35 patients with strands on mitral valve, 32 patients with strands on aortic valve, and 16 patients with strands on both valves. Distribution of LEs at each valve leaflet were shown in Figure. Right coronary cusp of aortic valve (42%) and P2 of mitral valve (35%) were high prevalence among leaflets.

Conclusions
3D-TEE provides an update prevalence of LEs. The prevalence of LEs might be potentially high in the real world.
Abstract P1526 Figure.
P1530 Dense spontaneous echo contrast and thrombus in patients on new oral anticoagulant and warfarin therapy: a retrospective audit
Authors: Thakur A , Thananjeyan A , Garrett C , Reeks M , Khaja S , Shugman I , Premawardhana U , Kadappu K K 
Published: January 2020

Abstract

Background
Cardioembolic stroke is a known complication of atrial fibrillation (AF), which is increasing in global prevalence. Spontaneous echo contrast (SEC) in the left atrium (LA) is a precursor for thrombus formation detected on transesophageal echocardiography (TEE). There is limited data regarding the prevalence of dense SEC and/or left atrial thrombus (LAT) detected by TEE in patients on novel oral anticoagulants (NOACs) compared with Warfarin.

Purpose
To determine and compare the prevalence of dense SEC and/or LAT among patients with AF/atrial flutter undergoing TEE while on continuous NOAC or Warfarin therapy.

Methods
Retrospective analysis of prospectively entered data for all patients who were on continuous oral anticoagulants and underwent TEE with DC cardioversion, over a 9-year period (1st January 2011 to 31st December 2018) at a public teaching hospital in NSW, Australia. SEC was classified according to emptying flow velocities, as per the European Association of Cardiovascular Imaging guidelines.

Results
Among the 195 patients, 94 (48%) patients were on NOAC therapy (52% Apixaban, 25% Rivaroxaban, 23% Dabigatran) while 101 (52%) patients were on Warfarin. There was no difference in age (mean ± SD: 64 ± 12 vs. 65 ± 13, p = 0.71) or proportion of males (71% vs 69%, p = 0.76) between patients on NOAC therapy compared with Warfarin. However, the NOAC therapy group had a lower prevalence of ischaemic heart disease (IHD) (18% vs. 33%, p &lt; 0.05) and chronic kidney disease (CKD) (2% vs. 19%, p &lt; 0.001), in addition to a lower CHA2DS2-VASc score (2.1 ± 1.7 vs 2.7 ± 1.7, p = 0.03) and higher haemoglobin levels (145.3 ± 19 vs 133.8 ± 24, p = 0.001). The overall rate of dense SEC and/or LAT detected by TEE was 9.7%. There was no significant difference in the prevalence of dense SEC and/or LAT between patients on NOACs and Warfarin (6.4% vs. 12.9%, p = 0.13). On multivariable analysis of IHD, CKD, Warfarin, NOACs and CHA2DS2-VASc score, there was no significant difference in prevalence of SEC/LAT between Warfarin and NOACs.

Conclusions
In this study, 6.4% of patients on continuous NOACs and 12.9% of patients on Warfarin therapy had dense SEC and/or LAT detected by TEE. Although the trend towards higher rates of dense SEC and pre-thrombus in the Warfarin group did not reach statistical significance, it still holds clinical significance as these patients cannot be cardioverted. Therefore, these data support the need to consider anticoagulant optimisation in the overall management of patients with SEC.
P1533 Early evaluation of global longitudinal strain and biomarkers at initiation of trastuzumab treatment in breast cancer patients
Authors: Banke A , Schou M , Dahl J , Frederiksen P , Videbaek L , Ewertz M , Cold S , Moeller J 
Published: January 2020

Abstract

Funding Acknowledgements
The Danish Heart Foundation, Copenhagen (grant number: 14-R97-A5188-22839 and 15-R99-A5940). The Research Fond of the Region of Southern Denmark.

Background
Global longitudinal strain (GLS) is recommended to detect subclinical changes preceding reduced left ventricular ejection fraction (LVEF) in trastuzumab related cardiotoxicity. The possibility to detect signs of acute myocardial deterioration at treatment initiation is not thoroughly investigated. Accordingly, the aim of this study was to assess changes in GLS and biomarkers within the first two weeks of trastuzumab treatment.
Methods
In a prospective cohort study 45 patients with non-metastatic breast cancer (age 54, LVEF 62.8% (SD ± 3.6), GLS -19.9% (SD ± 2.1), 40% hypertension) were included. Examinations including echocardiography and measurement of troponin T and NT-proBrain Natriuretic Peptide were conducted before initiation of trastuzumab, at day 3, 7 and 14 and after 3, 6 and 9 months.

Results
A significant deterioration in LVEF, GLS, s’, e’ septal and s’RV occurred during the 9 months study period and was proceed by significant changes in all these parameters within the first 14 days.
After 14 days 12 patients (27%) had an increase in GLS ≥10 %, which was associated with significantly lower LVEF at nine month at 55.2% (SD ± 4.1) vs. 59.5% (SD ± 3.5) (p = 0.001) compared to patients with &lt;10 % early increase in GLS (Figure 1). No difference in plasma concentrations of cardiac biomarkers was observed between the two groups.

Conclusion
In this cohort study deteriorations in key echocardiographic parameters were detected within the first two weeks of trastuzumab treatment, and an early 10 % increase in GLS was associated with a lower LVEF at nine months.
Abstract P1533 Figure 1
P1534 Clinical feasibility of 4D myocardial speckle tracking strain analysis in soccer referee: comparison to 2D strain
Authors: Stefani L , Leone B L , Zappelli E Z , Toncelli L T , Galanti G G 
Published: January 2020

Abstract

Funding Acknowledgements
no

OnBehalf
no

Background
Quantitative analysis of deformation parameters can provide evidence about the presence of disease . Speckle tracking (ST)strain is recently largely used in sports medicine, as an usefull tool to add value to the traditional echo information .Especially 4D echo-strain is emerging in this context despite not yet completely explored. The study aim to verify the feasibility of the 4D strain analysis , compared to the 2D ST strain data, in a class of international trained soccer referee. Materials and methods : a group of 25 soccer referee ( aged 45,5 ± 5) underwent to an EMT, conducted at the 85% of their effort to obtain the eligibility. An 2D echocardiographic evaluation was also performed with the measurements of the systolic-diastolic parameters . A specific investigation for the 2D and 4D strain analysis by X-Strain-Esaote software, was possible from the 2C,3C;4C apical view chambers, acquired as cine loop. The study was completed by the study of the circumferential strain calculated from short axis view, from the images of the basal and medium LV segments. Results : all 2D echo parameters were normal (LVDD: 50,56 ± 2 mm,68; LVSD: 35,4 ± 2,3 mm; EF: 65,76 ±1,78%; E/A:1,73 ± 0,35 ; RV:23,71 ± 1 mm) The 2D GLS ( -22,29 ± 2,64); Circumferential strain( Basal -22,29 ± 5,3; Apical -25,66 ± 5,8 ) were in the normal range. No statistical differences ( P:NS) were observed comparing the mean GLS(21,60 ± 2,68) to the LV 4D strain( -21,24 ± 2,75) Conclusions : 4D strain completes and strengthens the role of the 2D strain in evaluating the myocardial function contributing to exclude eventual undiscovered disease. Especially in athletes, often checked in a short time the combination of the two methods should be widely proposed .More studies will be necessary in future to confirm this hypothesis.
Abstract P1534 Figure. 4D strain
P1535 Interventricular interaction can result in right ventricular dysfunction in interventricular septum involved myocardial infarction patient
Authors: Park C S , Gwon A , Ahn H S , Kim G H , Cho J S , Youn H J 
Published: January 2020

Abstract

Background
Previous studies revealed that interventricular septal thickness is related to right ventricular dysfunction after anterior myocardial infarction. This finding suggest that interventricular septal function can affect right ventricular function in myocardial infarction patients. We assumed that right ventricular free wall strain values measured using dedicated software can be affected in the setting of ischemic insult on interventricular septum in long-term follow up.

Methods
The patients diagnosed as acute myocardial infarction due to left anterior descending artery disease who underwent successful revascularization were enrolled. Echocardiographic exams were performed at least 2 times, within 72 hours and 1 year after the revascularization. Strain values of interventricular septum and right ventricular free wall were derived from the raw-dicom images. The analysis was performed using the dedicated software for the measurement of right ventricular strain.

Results
Total 65 patients were enrolled. The values of global left ventricular strain were increased after the follow up. There were no changes in global longitudinal strain of the right ventricle. But longitudinal stain values acquired from right ventricular free walls were decreased even the strain values measured at left ventricle and interventricular septum were improved.

Conclusion
Interventricular septal dysfunction due to ischemic injury can affect long term right ventricular dysfunction. This finding suggests the interventricular dependence between cardiac chambers and can provide the development of heart failure in myocardial infarction patient even after the successful revascularization.
Strain values of both ventricles Left ventricle after revascularization (n = 65) 1 year later (n = 65) P values Global longitudinal strain (%) -12.84 ± 4.50 -15.62 ± 4.45 &lt;0.001 Septal longitudinal strain (%) -10.77 ± 5.96 -14.02 ± 5.26 &lt;0.001 Right ventricle Global longitudinal strain (%) -19.36 ± 4.57 -19.47 ± 4.83 0.872 Septal longitudinal strain (%) -14.82 ± 4.48 -16.43 ± 6.03 0.055 Free wall longitudinal strain (%) -20.23 ± 5.33 -17.82 ± 5.70 0.010
Abstract P1535 Figure. Right ventricular segmental strain