bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competing Perceptual Salience in a Visual Word Recognition Task Differentially Affects Children With and Without Autism Spectrum Disorder
Authors: Venker Courtney E. , Mathée Janine , Neumann Dominik , Edwards Jan , Saffran Jenny , Ellis Weismer Susan 
Published: December 2020

Differences in visual attention have long been recognized as a central characteristic of autism spectrum disorder (ASD). Regardless of social content, children with ASD show a strong preference for perceptual salience—how interesting (i.e., striking) certain stimuli are, based on their visual properties (e.g., color, geometric patterning). However, we do not know the extent to which attentional allocation preferences for perceptual salience persist when they compete with top‐down, linguistic information. This study examined the impact of competing perceptual salience on visual word recognition in 17 children with ASD (mean age 31 months) and 17 children with typical development (mean age 20 months) matched on receptive language skills. A word recognition task presented two images on a screen, one of which was named (e.g., Find the bowl!). On Neutral trials, both images had high salience (i.e., were colorful and had geometric patterning). On Competing trials, the distracter image had high salience but the target image had low salience, creating competition between bottom‐up (i.e., salience‐driven) and top‐down (i.e., language‐driven) processes. Though both groups of children showed word recognition in an absolute sense, competing perceptual salience significantly decreased attention to the target only in the children with ASD. These findings indicate that perceptual properties of objects can disrupt attention to relevant information in children with ASD, which has implications for supporting their language development. Findings also demonstrate that perceptual salience affects attentional allocation preferences in children with ASD, even in the absence of social stimuli.Lay SummaryThis study found that visually striking objects distract young children with autism spectrum disorder (ASD) from looking at relevant (but less striking) objects named by an adult. Language‐matched, younger children with typical development were not significantly affected by this visual distraction. Though visual distraction could have cascading negative effects on language development in children with ASD, learning opportunities that build on children's focus of attention are likely to support positive outcomes.
Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry
Authors: Djemal Leïla , Fournier Clemence , von Hagen Joerg , Kolmar Harald , Deparis Véronique 
Published: December 2020

AbstractEvents of viral contaminations occurring during the production of biopharmaceuticals have been publicly reported by the biopharmaceutical industry. Upstream raw materials were often identified as the potential source of contamination. Viral contamination risk can be mitigated by inactivating or eliminating potential viruses of cell culture media and feed solutions. Different methods can be used alone or in combination on raw materials, cell culture media, or feed solutions such as viral inactivation technologies consisting mainly of high temperature short time, ultraviolet irradiation, and gamma radiation technologies or such as viral removal technology for instance nanofiltration. The aim of this review is to present the principle, the advantages, and the challenges of high temperature short time (HTST) technology. Here, we reviewed effectiveness of HTST treatment and its impact on media (filterability of media, degradation of components), on process performance (cell growth, cell metabolism, productivity), and product quality based on knowledge shared in the literature.
Simulation for senior undergraduate education of robot engineering based on Webots
Authors: Yue Haosong , Miao Jinyu , Zhang Jinqing , Fan Changbo , Xu Dong 
Published: December 2020

AbstractIn this paper, a comprehensive simulation framework is presented for senior undergraduates of robot engineering based on open‐source simulation software, Webots. In our curriculum, a virtual quadruped robot is used to test different theories. First, students should design the physical structure of the robot and select proper drivers according to the requirements on its motion ability. Then, the kinematics and workspace of each leg should be analyzed. To overcome different terrains, terrain recognition, and motion planning methods are presented. Finally, the processes of building a virtual robot and its test environment are introduced. Simulation results demonstrate that it is possible to test different robot techniques in our proposed simulation framework. Teaching practice and feedback from students show their promotion of understanding of robot theories. Their interest in robots are also increased.
Researching online counselling and psychotherapy: The past, the present and the future
Authors: Hanley Terry 
Published: December 2020

AbstractThis paper reflects upon the history of online counselling and psychotherapy research. It provides a reflection upon the growing body of research in this field and discusses the impact of the recent global COVID‐19 pandemic upon it. It specifically argues that the pandemic has been an evolutionary catalyst for developments in online therapy. Therapeutic practices, and attitudes towards them, have changed in ways that will alter the shape and form of therapies in the future. As a consequence, research into online therapeutic work needs to be responsive and adapt to this changing world. Counselling and psychotherapy researchers therefore have to situate themselves in a way that allows them to keep one foot in the present and one foot in the future to stay abreast of technological developments. There may be a reluctance to do so from some areas in the therapeutic profession, but their presence might prove vital in ensuring that ethical sensitivity, which acknowledges and values the complexity of the human experience, remains at the foreground of psychological support.
Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications
Authors: Bolze Holger , Riewe Juliane , Bunjes Heike , Dietzel Andreas , Burg Thomas P. 
Published: December 2020

AbstractMicrofluidic processes are of great interest for the production of nanoparticles with reproducible properties. However, in real systems, it is difficult to completely exclude incidental production of larger particles, which can contaminate the product or clog downstream process modules. A class of microfluidic filters was devised for eliminating particulate contamination in multistage continuous‐flow processes. To achieve high throughput and filtration efficiency, a high‐surface‐area filter with an application‐adapted bonding method was developed. As a model application, the filtration efficiency was analyzed for lipid nanoparticles made by microfluidic antisolvent precipitation and the results were compared with requirements of the European and US guidelines.
General anesthesia is not superior to sedation in clinical outcome and cost‐effectiveness for ablation of persistent atrial fibrillation
Authors: Wang Zhengyan , Jia Lihong , Shi Tieying , Liu Changli 
Published: December 2020

AbstractBackgroundThe strategy of anesthesia used during ablation of atrial fibrillation (AF) remains controversial. This study aimed to compare sedation with general anesthesia (GA) for catheter ablation of AF.HypothesisThe presence of AF is associated with an increased risk of stroke and heart failure and decreased quality of life and survival.MethodsWe carried out a retrospective single‐centered study with 351 patients undergoing the first ablation procedure for AF under sedation or GA. The main outcome was freedom from recurrence of AF at 1 year. The total time of staying at the ablation laboratory and procedure cost were also calculated.ResultsFreedom from atrial arrhythmia and ablation time did not differ between AF patients under sedation and GA (77.9% vs 79.9% and 42.27 ± 9.84 minutes vs 41.51 ± 9.27 minutes, respectively), while the total procedure time and cost were lower in patients who underwent sedation than GA (171.39 ± 45.09 minutes vs 202.92 ± 43.85 and 8.00 ± 7.02 CNY vs 8.79 ± 11.63 CNY, respectively).ConclusionGA is not superior to sedation, in terms of ablation time and freedom from atrial arrhythmia at 1 year, whereas patients with GA had more anesthesia time and procedure cost than sedation.
Popularity and correlation aware data replication strategy based on half‐life concept and clustering in cloud system
Authors: Chellouf Maawya , Hamrouni Tarek 
Published: December 2020

SummaryIn the new millennium, a myriad of large‐scale applications (e.g., social networks, ecommerce, internet of things, and scientific experiments) often generate large volumes of data. Given their volumes, their heterogeneous and distributed nature, the management of such data constitutes a challenge for distributed systems, particularly cloud computing. In this regard, data replication is a well‐known and effective data management technique that consists in creating multiple copies of the same data in different storage resources. In this article, we propose a popularity and correlation based data replication strategy, called PCDR. The main idea of our strategy is to replicate a set of the most popular correlated file groups based on files access history analysis. In this respect, the popularity of the files in each group is determined while taking into consideration temporal locality. Moreover, a clustering technique is used to find groups of correlated files. Using the CloudSim simulator, extensive experimentations show that our proposed strategy outperforms other strategies for several evaluation metrics.
Model Studies on the Formation of the Solid Electrolyte Interphase: Reaction of Li with Ultrathin Adsorbed Ionic‐Liquid Films and Co3O4(111) Thin Films
Authors: Forster‐Tonigold Katrin , Kim Jihyun , Bansmann Joachim , Groß Axel , Buchner Florian 
Published: December 2020

AbstractIn this work we aim towards the molecular understanding of the solid electrolyte interphase (SEI) formation at the electrode electrolyte interface (EEI). Herein, we investigated the interaction between the battery‐relevant ionic liquid (IL) 1‐butyl‐1‐methylpyrrolidinium bis(trifluoromethylsulfonyl)imide (BMP‐TFSI), Li and a Co3O4(111) thin film model anode grown on Ir(100) as a model study of the SEI formation in Li‐ion batteries (LIBs). We employed mostly X‐ray photoelectron spectroscopy (XPS) in combination with dispersion‐corrected density functional theory calculations (DFT‐D3). If the surface is pre‐covered by BMP‐TFSI species (model electrolyte), post‐deposition of Li (Li+ ion shuttle) reveals thermodynamically favorable TFSI decomposition products such as LiCN, Li2NSO2CF3, LiF, Li2S, Li2O2, Li2O, but also kinetic products like Li2NCH3C4H9 or LiNCH3C4H9 of BMP. Simultaneously, Li adsorption and/or lithiation of Co3O4(111) to LinCo3O4 takes place due to insertion via step edges or defects; a partial transformation to CoO cannot be excluded. Formation of Co0 could not be observed in the experiment indicating that surface reaction products and inserted/adsorbed Li at the step edges may inhibit or slow down further Li diffusion into the bulk. This study provides detailed insights of the SEI formation at the EEI, which might be crucial for the improvement of future batteries.
Heteroepitaxial Growth of 1T MoS2 Nanosheets on SnO2 with Synergetic Improvement on Photocatalytic Activity
Authors: Shan Songting , Zhu Shuaishuai , Pan Zhigang , Lu Yinong , Liu Yunfei , Tao Yaqiu 
Published: December 2020

AbstractMolybdenum disulfide has promising applications from electronics to catalysis. Facile controlled synthesis of desired MoS2 phase and improving optical and electrical properties of MoS2 are under intensive investigation. The significant enhancement in photocatalytic activity is found in the heteroepitaxial structure of 1T MoS2 and SnO2 constructed using convenient hydrothermal method compared to 1T MoS2. High‐resolution transmission electronic microscopy demonstrates epitaxial growth of 1T MoS2 nanosheets on SnO2 nanoparticle based on an epitaxial relationship of zone axis MoS2[100]//SnO2[] and MoS2[100]//SnO2[] and plane MoS2(011)//SnO2(011) in both cases. Serving as substrate for growth of desired 1T MoS2 phase, smaller grain‐sized SnO2 is in favor of more effective epitaxial growth of 1T MoS2. The epitaxial structure formed between 1T MoS2 and SnO2 of 3–5 nm ensures stable electron transfer and thus a much‐improved photocatalytic activity. Direct evidence of epitaxial construction of desired 1T MoS2 nanosheets on SnO2 nanoparticles is provided, which accounts for the synergetic improvement on photocatalytic activity of MoS2–SnO2 composite photocatalysts.
Exploiting the Degradation Mechanism of NCM523 || Graphite Lithium‐Ion Full Cells Operated at High Voltage
Authors: Klein Sven , Bärmann Peer , Beuse Thomas , Borzutzki Kristina , Frerichs Joop E. , Kasnatscheew Johannes , Winter Martin , Placke Tobias 
Published: December 2020

AbstractInvited for this month′s cover is the group of Tobias Placke and Martin Winter at the MEET Battery Research Center (University of Münster). The image shows the failure mechanism of high‐voltage operated NCM523 || graphite lithium‐ion cells, that is, the dissolution of transition metals (Mn, Co, Ni) from the NCM523 cathode and subsequent deposition at the graphite anode, resulting in formation of Li metal dendrites. The Full Paper itself is available at 10.1002/cssc.202002113.
Low‐voltage and high‐speed stand‐alone multiple‐input complex gates for error correction coding applications
Authors: Rafiee Maliheh , Ghaznavi‐Ghoushchi Mohammad‐Bagher 
Published: December 2020

SummaryThis paper presents two low‐voltage high‐speed shallow‐depth current mode logic (CML) topologies. The number of stacked transistors of these proposed structures decreases between VDD to GND. Reduce stacks in proposed gates enhance the circuit to operate at lower supply voltages. Therefore, the proposed logic causes to use of a stand‐alone multiple‐input gate instead of a low‐input gate. The use of decomposing multiple‐input gate for some input series causes error in the output of the circuit. In advanced technologies with size scaling down, the reliability and correctness of data in memories are essential issues. Error correction codes (ECCs) are used for protecting memories against faults. Reducing power consumption with preserving speed is vital in the design of ECCs. The units of ECCs are composed of multiple‐input gates; hence, using a low‐voltage high‐performance structure is required. The essential properties of the proposed logic are low‐voltage and high‐speed operation modes. It also gains in delay improvement of the proposed structure and multiple‐tailed current mode logic (MTCML) than source‐coupled logic (SCL) about 27% and 21% in the low‐voltage design. The final power delay product (PDP) of proposed logic and MTCML is improved by about 14% and 11% than SCL.
Neuregulin‐4 contributes to the establishment of cutaneous sensory innervation
Authors: Howard Laura , Wyatt Sean , Davies Alun M. 
Published: December 2020

AbstractRecent work has shown that neuregulin‐4 (NRG4) is a physiological regulator of the growth of sympathetic axons and CNS dendrites in the developing nervous system. Here, we have investigated whether NRG4 plays a role in sensory axon growth and the establishment of cutaneous sensory innervation. Imaging early nerve fibers in the well‐characterized cutaneous trigeminal territory, the brachial plexus, and thorax revealed very marked and highly significant decreases in nerve fiber length and branching density in Nrg4−/− embryos compared with Nrg4+/+ littermates. NRG4 promoted neurotrophin‐independent sensory axon growth from correspondingly early trigeminal ganglion and DRG neurons in culture but not from enteroceptive nodose ganglion neurons. High levels of Nrg4 mRNA were detected in cutaneous tissues but not in sensory ganglia. Our findings suggest that NRG4 is an important target‐derived factor that participates in the establishment of early cutaneous sensory innervation.
American lobster postlarvae alter gene regulation in response to ocean warming and acidification
Authors: Niemisto Maura , Fields David M. , Clark K. Fraser , Waller Jesica D. , Greenwood Spencer J. , Wahle Richard A. 
Published: December 2020

AbstractAnthropogenic carbon emissions released into the atmosphere is driving rapid, concurrent increases in temperature and acidity across the world's oceans. Disentangling the interactive effects of warming and acidification on vulnerable life stages is important to our understanding of responses of marine species to climate change. This study evaluates the interactive effects of these stressors on the acute response of gene expression of postlarval American lobster (Homarus americanus), a species whose geographic range is warming and acidifying faster than most of the world's oceans. In the context of our experiment, we found two especially noteworthy results: First, although physiological end points have consistently been shown to be more responsive to warming in similar experimental designs, our study found gene regulation to be considerably more responsive to elevated pCO2. Furthermore, the combined effect of both stressors on gene regulation was significantly greater than either stressor alone. Using a full factorial experimental design, lobsters were raised in control and elevated pCO2 concentrations (400 ppm and 1,200 ppm) and temperatures (16°C and 19°C). A transcriptome was assembled from an identified 414,517 unique transcripts. Overall, 1,108 transcripts were differentially expressed across treatments, several of which were related to stress response and shell formation. When temperature alone was elevated (19°C), larvae downregulated genes related to cuticle development; when pCO2 alone was elevated (1,200 ppm), larvae upregulated chitinase as well as genes related to stress response and immune function. The joint effects of end‐century stressors (19°C, 1,200 ppm) resulted in the upregulation of those same genes, as well as cellulase, the downregulation of calcified cuticle proteins, and a greater upregulation of genes related to immune response and function. These results indicate that changes in gene expression in larval lobster provide a mechanism to respond to stressors resulting from a rapidly changing environment.
Molybdenum (VI) Complexes Containing Pyridylimine Ligands: Effect of the Imine Nitrogen Substituent in the Epoxidation Reaction
Authors: Martínez‐Martínez Daniel , Santiago M. León , Toscano Rubén A. , Amézquita‐Valencia Manuel 
Published: December 2020

AbstractA series of pyridylimine ligands with variations of the substituent at the imine nitrogen were synthesized and coordinated to the [MoCl2O2] core. The novel molecular structures of the complexes were fully characterized by 1H and 13C NMR, FT‐IR, ESI, EA, and X‐ray crystallography, and their catalytic activity was studied for the epoxidation of alkenes using tert‐butyl hydroperoxide (TBHP) as the oxidant. The new complexes showed excellent catalytic activity and fine selectivity in the epoxidation reaction compared with similar homogeneous molybdenum complexes. The results demonstrated that there is a significant change in the catalytic performance, depending on the alkyl arm on the structure of the pyridilimine ligand. The catalytic results indicated that complex [MoCl2O2(L)] (L: N‐(2‐Pyridinylmethylene)‐1‐tert‐butylimine) C5 is the best catalytic precursor in the epoxidation of cyclohexene (TON: 92920 and TOF: 30974 h−1).
Systematic Study of the Stereoelectronic Properties of Trifluoromethylated Triarylphosphines and the Correlation of their Behaviour as Ligands in the Rh‐Catalysed Hydroformylation
Authors: Herrera Daniel , Peral Daniel , Cordón Mercedes , Bayón J. Carles 
Published: December 2020

AbstractThe stereoelectronic properties of a series of trifluoromethylated aromatic phosphines have been studied using different approaches. The σ‐donating capability has been evaluated by nuclear magnetic resonance (NMR) spectroscopy of the selenide derivatives and the protonated form of the different trifluoromethylated phosphines. The coupling constants between phosphorous and selenium (1JSeP) and phosphorous and hydrogen (1JHP) can be predicted by empirical equations and correlate the basicity of the phosphines with the number and relative position of trifluoromethyl groups. In contrast, the π‐acceptor character of the ligands has been evaluated by measuring the frequency of the CO vibration in the infrared (IR) spectra of the corresponding Vaska type iridium complexes ([IrCl(CO)(PAr3)2], PAr3=triarylphosphine). Moreover, the correlation between the electronic properties and the performance of these phosphines as ligands in the rhodium‐catalysed hydroformylation of 1‐octene has been established. Phosphines with the lowest basicity, that are those with the highest number of trifluoromethyl groups, gave rise to more active catalytic systems.
Novel Ru(II)/Os(II)‐Exchange Homo‐ and Heterometallic Polypyridyl Complexes with Effective Energy Transfer
Authors: Liu Zi Ning , He Chi Xian , Yin Hong Ju , Yu Shi Wen , Xu Jian Bin , Dong Jian Wei , Liu Yan , Xia Shu Biao , Cheng Fei Xiang 
Published: December 2020

AbstractTwo novel homometallic Ru−Ru and heterometallic Ru−Os dimers and trimers, [MII(bpy)2(4‐tpy‐4′‐methyl‐2,2′‐bipyridine)MII(tpy)]4+ and [MII(bpy)2](4‐tpy‐4′‐tpy‐2,2′‐bipyridine)(MII(tpy))2]6+, have been first prepared and characterized. Electrochemical properties of the metal‐based reversible oxidation and ligand‐based reduction are measured. Spectroscopic analysis of these complexes exhibits for every Ru‐ or Os‐based subunit an individual intense absorption spectrum extended over the entire UV and visible region. The heteronuclear complexes [RuII(bpy)2(4‐tpy‐4′‐methyl‐2,2′‐bipyridine)OsII(tpy)]4+, [RuII(bpy)2](4‐tpy‐4′‐tpy‐2,2′‐bipyridine)(OsII(tpy))2]6+, and [OsII(bpy)2](4‐tpy‐4′‐tpy‐2,2′‐bipyridine)(RuII(tpy))2]6+ display a weak emission spectrum in the near‐infrared region (NIR). The luminescence of the polynuclear assemblies is quantitatively quenched, by intramolecular energy transfer to the lower‐lying metal‐to‐ligand charge transfer (3MLCT) and metal‐centered (3MC) state of the Os(II)‐based center or Ru(II)‐terpyridine moiety at room temperature.
The survival benefit of lymph node dissection in resected T1–2, cN0 supraglottic cancer: A population‐based propensity score matching analysis
Authors: Fang Ruihua , Peng Liang , Chen Lin , Liao Jing , Wei Fanqin , Long Yudong , Wen Weiping , Sun Wei 
Published: December 2020

AbstractBackgroundThe survival benefit of clinically negative cervical lymph nodes (cN0) in patients with T1–2 supraglottic cancer (SC) remains unclear. This study aimed to comprehensively evaluate the prognostic value of lymph node dissection (LND) in patients with T1–2, cN0 SC.MethodsWe included 1036 confirmed T1–2, cN0 SC patients with clinicopathological characteristics between 2004 and 2015, based on the Surveillance, Epidemiology, and End Results program (SEER) database. The association between LND and overall survival (OS) was investigated by the Kaplan–Meier method.ResultsBefore propensity score matching (PSM), patients selected for LND had better OS, compared to patients did not receive LND (5‐year OS: 62.6% vs 51.2%, respectively; p = 0.011). After PSM, the LND group also present significant improvement in prognosis (5‐year OS: 64.3% vs 51.7%, respectively; p < 0.01).ConclusionsLND was significantly associated with a more favorable prognosis compared with non‐LND in patients with T1–2, cN0 SC.