bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Bias Introduced in Estimated Glomerular Filtration Rate by the Inhibition of Creatinine Tubular Secretion from Common Antiretrovirals
Authors: Brunet Laurence , Wyatt Christina , Hsu Ricky , Mounzer Karam , Fusco Jennifer , Fusco Gregory 
Published: November 2020

Background Researchers must often rely on creatinine measurements to assess kidney function because direct glomerular filtration rates (GFR) and cystatin-c are rarely measured in routine clinical settings. However, HIV treatments often include dolutegravir, raltegravir, rilpivirine or cobicistat, which inhibit the proximal tubular secretion of creatinine without impairing kidney function, thus leading to measurement bias when using creatinine-based estimated GFR (eGFR). We developed eGFR correction factors to account for this potential bias. Methods 11,359 treatment-naive HIV-positive individuals in OPERA were included if they initiated dolutegravir, elvitegravir/cobicistat, darunavir/cobicistat, raltegravir, rilpivirine or efavirenz (control) with an eGFR >60 ml/min/1.73 m2. The eGFR was corrected by adding the median decrease reported in the literature to the calculated eGFR; correction factors were not validated. Incidence rates of eGFR <60 ml/min/1.73 m2 (Poisson regression) and the relationship between regimens and eGFR <60 ml/min/1.73 m2 (multivariate Cox proportional hazards models) were estimated with and without eGFR correction. Results Without eGFR correction, dolutegravir, elvite-gravir/cobicistat, darunavir/cobicistat, raltegravir and rilpivirine based regimens were statistically significantly associated with a higher likelihood of eGFR <60 ml/min/1.73 m2 than efavirenz. With eGFR correction, each of these regimens was associated with a statistically significantly lower likelihood of eGFR <60 ml/min/1.73 m2 compared with efavirenz. Conclusions With increasing use of agents that inhibit tubular creatinine secretion, artificially low eGFR values could lead to erroneous conclusions in studies of HIV treatment and kidney outcomes measured with creatinine-based eGFR equations. Sensitivity analyses assessing the potential magnitude of bias arising from creatinine secretion inhibition should be performed.
Géopolitique d’une autre Afrique médiane
Authors: Giblin Béatrice 
Published: November 2020

Vingt-trois ans après la publication d’un numéro d’ Hérodote sur « une Afrique médiane », nous reprenons le même thème. Assurément les situations géopolitiques ont évolué : avec le temps les conséquences tragiques du génocide rwandais s’atténuent, la situation politique de la République démocratique du Congo s’est stabilisée. Néanmoins, les situations géopolitiques de ce vaste ensemble restent complexes et conflictuelles car rarement circonscrites à un seul État. Aussi, pour les comprendre, faut-il changer de niveau d’analyse en prenant en compte des espaces plus vastes et des temps plus ou moins longs. C’est l’approche suivie par les auteurs choisis par Roland Pourtier qui a piloté ce numéro, tous comme lui spécialistes de cette région. Leurs analyses précises grâce à leur profonde connaissance du terrain permettent de comprendre des conflits qui paraissent interminables.
Le bébé et sa famille en jeu(x)
Authors: Laub Sophie 
Published: November 2020

Dans cet article, l’auteur, pédopsychiatre et thérapeute systémique, propose de présenter le dispositif clinique qu’elle a mis en place dans sa pratique avec les familles au sein d’un service de soins en périnatalité. Le dispositif s’appuie sur la Consultation systémique et le Jeu du pique-nique issus des travaux du Centre d’étude de la famille de Lausanne. La dialectique systémique de recadrage, d’hypothétisation et de circularité en est le cadre théorique. Ce contexte expérientiel lui a permis d’explorer deux hypothèses de travail : la possibilité et l’intérêt d’appréhender la dynamique familiale en contexte périnatal ; l’utilisation de la temporalité spécifique en périnatalité comme levier thérapeutique afin de mobiliser les ressources et compétences groupales. La Consultation jeux familiaux, équivalente à peine remaniée de la Consultation systémique, est décrite et illustrée à partir de la situation de Gaston et de sa famille.
Cross-contamination is a risk associated with short-term insect specimen storage
Authors: Zettler Jennifer A. , Kohler Brian , Ness Traci , Buske Heather , Lipat Ariel Joy 
Published: November 2020

AbstractMolecular analyses of DNA samples necessitate careful attention to experimental protocols to prevent contamination of samples during the specimen collection and DNA extraction, amplification, and visualisation stages. When these studies involve insects that are collected in the field, standard procedures require samples to be individually sorted and stored in single tubes to prevent cross-contamination of DNA between specimens. This additional step can be time consuming and impractical when the survey population is large. The focus of our study was to experimentally determine if this assumed contamination risk is valid and if it varies with storage conditions. To test this, we co-stored a single intact fruit fly (Drosophilia melanogaster) (Diptera: Drosophilidae) known to be infected with the bacterial endosymbiont Wolbachia (Anaplasmataceae) with uninfected flies in tubes for three-hour, 24-hour, and one-week durations. For each treatment time, replicates of five tubes contained one infected fly and either one or five uninfected flies (1:1 and 1:5 ratios). Overall, eight of 30 tubes had contamination regardless of storage duration, and storing samples in crowded (1:5 ratio) conditions significantly increased the risk of Wolbachia DNA transference. Our results suggest that researchers should make efforts to sample and store specimens individually if cross-contamination is a concern in molecular analyses.
Beneficios económicos del uso de biodigestores en una empresa productora de quesos
Authors: Ruiz Almazán Ileana , Legarreta-González Martín Alfredo , Briseño García Arturo , Escalera Ochoa Laura , Castruita Esparza Luis Ubaldo 
Published: November 2020

A nivel mundial el uso de combustibles fósiles ha crecido conforme pasa el tiempo. Sin embargo, estos tipos de energía se están agotando, lo que conlleva a que sus costos aumenten, resultado de la oferta y demanda global, por lo que es necesario utilizar otro tipo de energías que no afecten al medio ambiente y tampoco recurran a grandes costos. Una de las maneras de generar energía renovable es a través del uso de biodigestores que permiten la producción de biogás, el cual está compuesto por una mezcla de gases, principalmente dióxido de carbono y metano. Este subproducto puede ser empleado como generador de energía eléctrica o como reemplazo de ciertos combustibles fósiles usados en las actividades diarias. El objetivo del estudio fue calcular el impacto económico generado por la producción y uso de biogás en una empresa productora de quesos en el municipio de Saucillo, Chihuahua, México. Esta empresa cuenta con una instalación de biodigestores, cuya producción de biogás es suficiente para reemplazar el uso del gas LP. En el presente estudio se analizó el impacto económico resultante del uso del proceso de biodigestión en la empresa, a través de diversos indicadores económicos aplicados conforme la información recolectada y de acuerdo a la metodología de Baca Urbina. Obteniendo como resultados una TIR de 46.72%, VPN de $4, 937, 745. 64 y una relación beneficio-costo de 1.80. Como conclusión, el uso de los biodigestores proporciona un impacto aceptable y favorable mostrando que la inversión del proyecto es rentable para la empresa.
Antioxidant and Anti-inflammatory Protective Properties of Thai Shallot (Allium ascalonicum cv. Chiangmai) Juice on Human Vascular Endothelial Cell Lines (EA.hy926)
Authors: OUNJAIJEAN Sakaewan , CHACHIYO Sukanya , KULPRACHAKARN Kanokwan , BOONYAPRANAI Kongsak , SRICHAIRATANAKOOL Somdet , RERKASEM Kittipan 
Published: November 2020

Oxidative stress and inflammation are 2 major contributors to numerous life-threatening disorders, including vascular pathologies. Shallots (Allium ascalonicum) are a type of red onion which grows in Southeast Asia. Bulbs of this plant are used both as a food ingredient and in traditional medicine. This study attempted to investigate the possible ways that juice extracted from Thai shallot (A.ascalonicum cv. Chiangmai) bulbs could be used in the prevention of cardiovascular complications. The antioxidative and anti-inflammatory effects of shallot juice extract (SHE) on human vascular endothelial cells (EA.hy926) were investigated. Cell viability was evaluated by MTT assay, membrane lipid peroxidation by thiobarbituric acid reactive substances assay, intracellular reactive oxygen species (ROS) production by the fluorescent probe 6-carboxy-2'-7'-dichlorofluoresceine, and interleukin-6 (IL-6) released by ELISA. The shallot juice showed extremely low cytotoxicity against EA.hy926 cells, with IC50 of 41.9 and 27.3 mg/ml for 24 h- and 48 h-incubation, respectively. SHE reduced the iron-induced malondialdehyde production in a dose-dependent manner. The extract also demonstrated antioxidant activity as shown by a significant reduction of H2O2-induced ROS production at a low concentration (< 200 mg/ml). Furthermore, SHE significantly attenuated the level of IL-6 released during lipopolysaccharide stimulation (p < 0.05). It is of interest that the juice extracted from Thai shallot bulbs demonstrated both cellular antioxidant and anti-inflammatory properties in endothelial cell models, combined with a reduction in toxicity. Shallot extract could be considered as a nutraceutical for the prevention or management of vascular diseases as it is related to oxidative stress and inflammation.
INOVAÇÃO SOCIAL
Authors: Prim Marcia Aparecida , R. Silva de Aguiar Ranieri , Aparecida Dandolini Gertrudes 
Published: November 2020

A lógica da sociedade que se desenvolve pautada nas premissas puramente econômicas, está sendo cada vez mais contestada. Ações que fomentam a inovação como o propósito social se faz cada vez mais necessária, para a um desenvolvimento sustentável e igualitário. A inovação social representa uma terceira via desse desenvolvimento e se apresenta em diversos contextos. O objetivo deste estudo é apresentar as diversas perspectivas tema de inovação social, como forma de contribuir para a clarificação deste fenômeno. Para tanto se realizou uma revisão da literatura nas bases Google Scholar, a Scopus e a CAPES, com aplicação de métodos qualitativos. Como resultado observou-se que as principais diferenças estão conectadas com a governança, a forma de tomada de decisão, os processos colaborativos, juntamente com a diversidade de atores envolvidos no o logo de todo o seu processo.
El tiempo en el conflicto trabajo-vida: El caso de las académicas en la universidad managerial
Authors: Fardella Cisternas Carla , Corvalán Navia Alejandra 
Published: November 2020

En la actualidad, el trabajo académico se caracteriza por un nuevo sistema de gestión enfocado en la medición permanente del desempeño, el financiamiento por competencia y la búsqueda de eficiencia y aceleración de la productividad científica. Si bien la probidad y los sistemas meritocráticos a la base de la nueva gestión académica han permitido mitigar arbitrariedades y reducir la brecha histórica de género en las universidades, las investigadoras exitosas han debido asumir un alto costo personal. La doble jornada laboral, la elección entre carrera científica o maternidad y la responsabilización por la conciliación trabajo-familia son parte del denominado conflicto trabajo-vida en el trabajo académico. Este artículo examina los repertorios interpretativos construidos por mujeres científicas en torno al tiempo y el conflicto trabajo-vida. Utilizando los datos producidos en 20 entrevistas activas a mujeres de diferentes universidades chilenas identificamos tres repertorios interpretativos: Padeciendo el tiempo; Administrando el tiempo y Re-inventando el tiempo. Estos resultados muestran cómo, aun cuando los tiempos del trabajo y la vida parecieran avanzar de formas incompatibles, las académicas buscan activamente su reconciliación.
Cotidiano e as artes de trabalhar: O trabalho na atenção básica em saúde
Authors: Tittoni Jaqueline , Gartner Tschiedel Rosemarie 
Published: November 2020

O artigo discute o cotidiano de trabalho na atenção básica em saúde, destacando a atividade das equipes de saúde da família junto à rede escolar e as atividades das agentes comunitárias de saúde. Aborda as micropolíticas cotidianas para pensar o trabalho vivo em ato, focando os modos de trabalhar e, em especial, as relações que se produzem nos cotidianos de trabalho. As resistências, com menor visibilidade, podem garantir a sua efetividade. O estudo acompanhou duas unidades de saúde em Porto Alegre-Brasil, uma na área central da cidade e outra, na periferia. A cartografia é a premissa metodológica, focando no acompanhamento dos processos cotidianos. O acompanhamento foi registrado em diários de pesquisa e nas produções fotográficas. Identificou-se que as equipes produzem arranjos entre as metas prescritas, as condições de trabalho e os recursos das comunidades. Tal fato se dá nos cotidianos de trabalho, que implicam afetos e sensibilidades, nem sempre visíveis nas prescrições e normativas que orientam o trabalho, advindo daí a importância de seu estudo.
Editorial Prácticas, procesos y cotidianeidad en la Psicología social
Authors: Baleriola Enrique , Reyes Espejo María Isabel , García-Quiroga Manuela , González-Barrientos Marcela , Fardella Carla , Sisto Vicente 
Published: November 2020

El estudio de lo cotidiano se presenta como un ámbito privilegiado para entender el funcionamiento de la sociedad, y por ende, de los modos en que la realidad puede ser transformada. El virus de la COVID-19 nos ha enseñado que no hay mayor transformación a escala planetaria que la interacción cotidiana cara a cara entre personas. En este número de temática especial sobre cotidianidad, Psicoperspectivas. Individuo y Sociedad, presenta trece artículos que, desde diferentes enfoques, países, marcos teóricos y ámbitos ponen de relieve la centralidad de lo cotidiano para el análisis y la transformación de realidades diversas en pleno siglo XXI, rodeados de redes sociales, fake news, procesos de privatización, memorias por recuperar, voces que escuchar, y todo por construir a las puertas de una nueva constitución en Chile. Y como hacer evidente lo cotidiano también se vuelve en una posibilidad de dejar registro de lo que acontece en nuestros tiempos se invita a recorrer este conjunto armonioso de trabajos. En ellos se podrá acceder a las inspiraciones, desafíos y creatividad de investigadores e investigadoras que, develando su quehacer, nos entregan una mirada crítica y reflexiva sobre sus prácticas y cotidianeidades en el ejercicio de investigar.
Effects of climate anomalies on warm-season low flows in Switzerland
Authors: Floriancic Marius G. , Berghuijs Wouter R. , Jonas Tobias , Kirchner James W. , Molnar Peter 
Published: November 2020

Abstract. Switzerland has faced extended periods of low river flows in recent years (2003, 2011, 2015 and 2018), with major economic and environmental consequences. Understanding the origins of events like these is important for water resources management. In this work, we provide data illustrating the individual and joint contributions of precipitation and evapotranspiration to low flows in both typical and dry years. To quantify how weather drives low flows, we explore how deviations from mean seasonal climate conditions (i.e., climate anomalies) of precipitation and potential evapotranspiration correlate with the occurrence and magnitude of annual 7 d lowest flows (Qmin) during the warm season (May through November) across 380 Swiss catchments from 2000 through 2018. Most warm-season low flows followed periods of below-average precipitation and above-average potential evapotranspiration, and the lowest low flows resulted from both of these drivers acting together. Low-flow timing was spatially variable across Switzerland in all years, including the driest (2003, 2011, 2015 and 2018). Low flows in these driest years were associated with much longer-lasting climate anomalies than the ≤2 month anomalies which preceded typical warm-season low flows in other years. We found that snow water equivalent and winter precipitation totals only slightly influenced the magnitude and timing of warm-season low flows in low-elevation catchments across Switzerland. Our results provide insight into how precipitation and potential evapotranspiration jointly shape warm-season low flows across Switzerland and potentially aid in assessing low-flow risks in similar mountain regions using seasonal weather forecasts.
El árbol paremiológico del doblete Alfonso y Alonso con su polimorfismo
Authors: Iglesias Ovejero Ángel 
Published: November 2020

Cet article fait partie d’une étude sur l’ “arbre parémiologique” des noms de personne (anthroponymes) les plus fréquents en espagnol, basée sur un corpus où ces signes sont des composants d’expressions phraséologiques et d’autres formes brèves (proverbier, parémiologie). Leur analyse générale a fait l’objet d’une thèse soutenue en 1987 dont on a offert postérieurement plusieurs échantillons particuliers. Á présent on développe la traditionalité d’Alfonso et d’Alonso (ironiquement considéré “archaïsme” par l’un de ses illustres porteurs, un maître à qui l’on rend ici un modeste hommage).
Il Dit de Merlin Mellot fra racconto tradizionale e riscrittura edificante
Authors: Lecco Margherita 
Published: November 2020

Se ha prestado poca atención al cuento medieval conocido bajo el título de Merlin Mellot: se puede decir que no se le ha dedicado ningún trabajo específico. En cambio es un texto interesante tanto por una identificación de género (oscila entre fabliau y dit, anticipa los desarrollos modernos de la novela), como en términos de material narrativo. Que se relaciona con un camino narrativo de una tradición quizás antigua, pero ciertamente tiene un éxito medieval y renacentista hasta la edad moderna, la historia conocida por los folkloristas bajo la indicación de The Fisherman and His Wife.
Environmental Health Risk Assessment of Fe, Zn, As, Cd and Pb Concentration in Selected Asian Rice Grain (Oryza sativa)
Authors: Tan Kok Weng , Khaw Eu Han 
Published: November 2020

This study was carried out to determine the concentration of chemical elements in food grains (Oryza Sativa). A total of eight brands of rice grains was selected which are commonly sold in major hypermarkets in Malaysia. The selection was based on the countries of origin (COO) namely Cambodia, Indonesia, Malaysia, Thailand, Vietnam, China, Japan and Taiwan. A total of 16 rice grain samples included both polished and unpolished rice grains in order to determine the concentration of Fe, Zn, As, Cd and Pb. From the laboratory result, it was found that the concentration of Fe, Zn, As, Cd and Pb was ranged from 0.067-14.446 mgkg‑1, 0.308-12.335 mgkg‑1, 0.000-0.048 mgkg‑1, 0.000-0.604 mgkg‑1 and 0.000-0.418 mgkg‑1 respectively. The rice grains samples from Vietnam, China and Cambodia showed that carcinogenic cancer risk for both adults and infants’ group (Cumulative lifetime cancer risk, CLCR >1x10-4).
Decadent Philosophy's Misunderstanding of the Body and the Artistic Flourishing of Culture: Comments on Nietzsche on the Decadence and Flourishing of Culture
Authors: Scott Jacqueline 
Published: November 2020

ABSTRACT
This article, presented in January 2020 to the North American Nietzsche Society at the American Philosophical Association Eastern Division Meeting, is a commentary on Andrew Huddleston's 2019 monograph, Nietzsche on the Decadence and Flourishing of Culture. The focus is on Nietzsche's critical and positive arguments about the psychological and physiological nature of decadence, Nietzsche's conception of cultural health, and the role of art and artists in Nietzschean flourishing cultures.
Virtue and Community in Mark Alfano's Nietzsche's Moral Psychology
Authors: Cristy Rachel 
Published: November 2020

ABSTRACT
This article, invited for presentation to the North American Nietzsche Society at the 2020 Pacific Division Meeting of the American Philosophical Association, is a commentary on Mark Alfano's 2019 monograph, Nietzsche's Moral Psychology. I commend Alfano's productive, innovative use of digital humanities methods as well as his more traditional textual interpretation. But I raise some doubts about Alfano's proposed criterion of “external integration” for a drive to qualify as a Nietzschean virtue: the claim that if a drive systematically and reliably meets with condemnation from an agent's community, it cannot be a virtue. I suggest that the criterion be amended either so that it is disapproval from the agent's true community, which for a solitary moral innovator may be an imagined community of past and future peers, that disqualifies a drive from virtue status; or so that community disapproval is disqualifying only if the agent internalizes it.
Two and a Half Cheers for Digital Humanities: Responses to Bamford, Cristy, and Reginster
Authors: Alfano Mark 
Published: November 2020

ABSTRACT
This article is a reply to critical commentaries by Rebecca Bamford, Rachel Cristy, and Bernard Reginster on my 2019 monograph, Nietzsche's Moral Psychology, invited by the North American Nietzsche Society for presentation at a book symposium planned for the 2020 Pacific Division Meeting of the American Philosophical Association.
An Australian Aboriginal in-prison restorative justice process: a worldview explanation
Authors: Anderson Jane 
Published: November 2020

An Australian Aboriginal in-prison restorative justice process: a worldview explanation
As a response to the over-representation of Australian Aboriginal offenders in Western Australian prisons and high rates of reoffending, this article presents a sketch of Western and Australian Aboriginal worldviews and core symbols as a basis for understanding the rehabilitative-restorative needs of this prisoner cohort. The work first reviews and argues that the Western-informed Risk-Need-Responsivity model of programming for Australian Aboriginal prisoners has limited value for preventing reoffending. An introduction and description are then given to an Aboriginal in-prison restorative justice process (AIPRJP) which is delivered in a regional Western Australian prison. The process is largely undergirded by an Australian Aboriginal worldview and directed to delivering a culturally constructive and corrective intervention. The AIPRJP uses a range of symbolic forms (i.e. ritual, myth, play, art, information), which are adapted to the prison context to bring about the aims of restorative justice. The article contends that culturally informed restorative justice processes can produce intermediate outcomes that can directly or indirectly be associated with reductions in reoffending.