bluuebunny/crossref_metadata_2025_split huggingface dataset:
Light-adjustable lens in eyes with a history of radial keratotomy
Authors: Webster Madison , Baartman Brandon , Jones Marlee , Terveen Daniel C. , Berdahl John P. , Thompson Vance , Kramer Brent A. , Ferguson Tanner J. 
Published: December 2024

Purpose:
To evaluate visual and refractive outcomes in eyes with a history of radial keratotomy (RK) implanted with the second-generation light-adjustable lens (LAL).

Setting:
Private practice, multiple locations.

Design:
Retrospective, consecutive case series.

Methods:
Eyes with a history of RK that underwent cataract surgery with implantation of the LAL and were targeted for emmetropia before lock-in were included. Data on the type and number of prior refractive surgeries were collected, in addition to the timing and number of postoperative adjustments. The primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity, and the percentage (%) of eyes within ±1.00 diopter (D), ±0.50 D, and ±0.25 D and of their refractive target.

Results:
94 eyes from 77 patients were included. 28% (n = 26) were a history of 4-cut RK, 12% (n = 11) were 6-cut RK, 55% (n = 52) were 8-cut RK, and 5% (n = 5) were 16-cut RK. Overall, 82% (n = 77) of all eyes achieved 20/25 UDVA or better, 74% (n = 70) of all eyes achieved UDVA of 20/20 or better, and 94% (n = 88) were correctable to 20/20 or better postoperatively. For refractive outcomes, 98% (n = 92) of eyes were within ±1.00 D of target, 88% (n = 83) were within ±0.50 D, and 69% (n = 65) were within ±0.25 D of preoperative refractive target.

Conclusions:
Patients with a history of RK achieved favorable visual and refractive outcomes with the LAL. Postoperative light adjustments should be delayed to allow for refractive stabilization. The LAL is a promising option for post-RK patients who are motivated to obtain favorable uncorrected acuity after cataract surgery.
Effectiveness and safety of a thermo-mechanical action device versus thermal pulsation device in the treatment of meibomian gland dysfunction
Authors: Sadri Ehsan , Verachtert Anthony , Parkhurst Gregory D. , Echegoyen Julio , Klein Ifat , Agmon Yael G. , Berdy Gregg J. 
Published: December 2024

Purpose:
To evaluate the safety and effectiveness of thermo-mechanical action (Tixel C, Novoxel) compared with thermal pulsation (LipiFlow, Johnson & Johnson) in meibomian gland dysfunction (MGD).

Setting:
Private clinics and University clinic, USA

Design:
Prospective, randomized (1:1), evaluator-masked, multicenter study

Methods:
Subjects with Ocular Surface Disease Index (OSDI) between 23 and 79, fluorescein tear break-up time (TBUT) <10 s and Meibomian Gland Score (MGS) ≤12 in each eye received bilateral thermo-mechanical action (TMA) or thermal pulsation (TP). The treatment consisted of three sessions, two weeks apart, for TMA and one session for TP. TBUT, OSDI, MGS, and corneal and conjunctival staining (CCS) were assessed at baseline and at Weeks 4 and 12 post-last treatment session. The primary effectiveness endpoint was change in TBUT at Week 4.

Results:
Among the 106 treated subjects (N=53 per group), TBUT improved significantly (p<0.001) by 3.0±3.2 and 3.1±4.3 seconds after TMA and 2.7±2.7 and 3.3±3.6 seconds after TP, at Week 4 and Week 12, respectively. The change in TBUT for TMA was non-inferior to TP (linear mixed-effects model, p<0.001). OSDI, MGS and CCS significantly improved from baseline (p<0.001), with no significant between-group differences (p>0.05). OSDI improved by 26.4±21.1 and 28.6±22.4 after TMA and 18.8±21.0 and 21.9±18.5 after TP, at Week 4 and Week 12, respectively. No device-related adverse event occurred in either group.

Conclusion:
TMA safely and effectively improved clinical signs and symptoms of evaporative dry eye disease associated with MGD over a 12-week period, comparable to TP.
Reorganization of lateral habenula neuronal connectivity underlies pain-related impairment in spatial memory encoding
Authors: Cardoso-Cruz Helder , Monteiro Clara , Galhardo Vasco 
Published: December 2024

Abstract
Dysfunctional hyperactivity of the lateral habenula nucleus (LHb) has emerged as a critical marker for pain-related mood impairments. Acting as a central hub, the LHb filters and disseminates pertinent information to other brain structures during learning. However, it is not well understood how intra-LHb activity is altered during cognitive demand under neuropathic pain conditions. To address this gap, we implanted an optrode structure to record neuronal activity in adult male CD (rat strain without definition) rats during the execution of a delayed nonmatch-to-sample (DNMS) spatial working memory (WM) task. We selectively modulated intra-LHb network activity by optogenetically inhibiting local LHb CaMKIIα (calcium calmodulin-dependent protein kinase II alpha)-expressing neurons during the delay phase of the DNMS task. Behavioral assessments were conducted using a persistent rodent model of neuropathic pain—spared nerve injury. Our results showed that the induction of neuropathic pain disrupted WM encoding accuracy and intra-LHb functional neuronal connectivity. This disruption was reversed by optogenetic inhibition of LHb CaMKIIα-expressing neurons, which also produced antinociceptive effects. Together, our findings provide insight into how intra-LHb networks reorganize information to support different task contexts, suggesting that the abnormal pain-related intra-LHb dynamic segregation of information may contribute to poor cognitive accuracy in male rodents during pain experiences.
The role of pain expectancy and its confidence in placebo hypoalgesia and nocebo hyperalgesia
Authors: Camerone Eleonora Maria , Tosi Giorgia , Romano Daniele 
Published: December 2024

Abstract
Placebo hypoalgesia and nocebo hyperalgesia, which exemplify the impact of expectations on pain, have recently been conceptualised as Bayesian inferential processes, yet empirical evidence remains limited. Here, we explore whether these phenomena can be unified within the same Bayesian framework by testing the predictive role of expectations and their level of precision (ie, expectation confidence) on pain, with both predictors measured at the metacognitive level. Sixty healthy volunteers underwent a pain test (ie, 8 noxious electrical stimuli) before (Baseline) and after (T0, T1, T2) receiving a sham treatment associated with hypoalgesic (placebo), hyperalgesic (nocebo), or neutral (control) verbal suggestions, depending on group allocation. Trial-by-trial expectations, their precision, and perceived pain were measured. Skin conductance response (SCR) was also recorded as an autonomic response marker. Bayesian linear mixed models analyses revealed that, for both placebo and nocebo, pain was predicted by expectations alone and by their interaction with expectations precision. In addition, the discrepancy between expected and perceived pain was predicted by expectation precision, with greater alignment between expected and perceived pain when precision was higher. This suggests that both placebo and nocebo responses are well described from a Bayesian perspective. A main effect of time for SCR was observed, suggesting habituation to painful stimuli. Our data provide evidence indicating that both placebo hypoalgesia and nocebo hyperalgesia can be unified within the same Bayesian framework in which not only expectations but also their level of precision, both measured at the metacognitive level, are key determinants of the pain inferential process.
Epidemiology of Musculoskeletal Injuries in Professional Ballet Dancers at the Opéra de Paris
Authors: Barreau Xavière , Courtin Cyril , Ramos-Pascual Sonia , Kumble Ankitha , Saffarini Mo , Nogier Alexis 
Published: December 2024

Objective:
To describe the incidence, location, and type of musculoskeletal injuries in ballet dancers at the Opéra de Paris from 2018 to 2023 and to evaluate the effect of COVID-19 on injury incidence.

Design:
Descriptive Retrospective Study.

Setting:
Primary.

Patients:
Professional ballet dancers registered at the Opéra de Paris across 5 seasons (September 1, 2018–June 30, 2023).

Independent variables:
Demographics (age, body mass index, sex, rank).

Main Outcome Measures:
Injury data (duration, mechanism, location, and type).

Results:
The incidence proportion of musculoskeletal injuries ranged from 47.1% to 72.6% per season between 2018 and 2023. Dancers most commonly sustained foot (49.3%) and ankle (45.1%) injuries, with 75.6% of dancers sustaining a lower limb injury. Compared with the 2018 to 2019 season, the risk of a dancer sustaining an injury was significantly lower in the COVID-19 season (2019–2020) (OR, 0.34; 95% CI, 0.21-0.53; P < 0.001), while the risk of an injury resulting in time loss was significantly lower in the 2022 to 2023 season (OR, 0.42; 95% CI, 0.27-0.64; P < 0.001).

Conclusions:
The incidence of musculoskeletal injuries in professional ballet dancers was as high as 72.6% per season between 2018 and 2023, with the most common injury location being the foot and ankle. Compared with that in the 2018 to 2019 season, the risk of a dancer sustaining an injury was significantly lower in the COVID-19 season (2019–2020). These findings can help anticipate musculoskeletal injuries in professional ballet dancers and improve injury prevention programs, by developing targeted training schemes.
Endothelial progenitor cells have high predictive value for ventricular remodeling after percutaneous coronary intervention in acute myocardial infarction
Authors: Ma Yongxiang , Niu Lijian , Zhang Jing , Yu Fei , Huang Wenjun 
Published: December 2024

Objective
Acute myocardial infarction (AMI) and the following heart failure are main causes of disability and death across the globe. Endothelial progenitor cell (EPC) levels are linked to AMI. Herein, we assessed the predictive value of EPCs for post-percutaneous coronary intervention (PCI) ventricular remodeling in AMI patients.

Methods
This study retrospectively analyzed 215 AMI patients receiving PCI, who were then categorized into the VR (n = 66) and N-VR (n = 149) groups as per whether they developed post-PCI ventricular remodeling. Left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and EPCs were measured. The correlations of LVEF and NT-pro-BNP with EPCs, the predictive value of EPCs for post-PCI ventricular remodeling, and the risk of post-PCI ventricular remodeling in AMI patients with different EPC levels were analyzed by Spearman’s analysis, receiver-operating characteristic curve, and Kaplan–Meier curve.

Results
LVEF and EPC levels were lower and NT-pro-BNP level was higher in the VR group than the N-VR group. EPC levels in the class III–IV group were lower than those in the class I–II group. EPC levels in AMI patients correlated positively with LVEF (r = 0.683) and negatively with NT-pro-BNP (r = −0.761). EPCs exhibited high predictive value for post-PCI ventricular remodeling in AMI [area under the curve (AUC) of 0.822] and anterior MI (AUC = 0.941) patients. AMI and anterior MI patients with low EPC levels had a higher risk of post-PCI ventricular remodeling.

Conclusion
Low EPC levels have high predictive value for post-PCI ventricular remodeling, and increase the risk of post-PCI ventricular remodeling in AMI patients.
Brief Report: Associations Between Gender and Solicited Adverse Events After Passive Infusion of VRC01 or Placebo in HVTN 704/HPTN 085
Authors: Theodore Deborah A. , Neradilek Moni , Gillespie Kevin , Edupuganti Srilatha , Hinojosa Juan Carlos , Lama Javier R. , De La Grecca Robert , Wu Yi H. , Davis Annet , Mangini Daniel , Andrew Philip , Marovich Mary A. , Zwerski Sheryl , Broder Gail , Andrasik Michele P. , Castor Delivette , Roxby Alison C. , Cohen Myron , Huang Yunda , Karuna Shelly T. , Sobieszczyk Magdalena E. 
Published: December 2024

Background:
Realizing the potential of HIV prevention options requires understanding product tolerability across diverse groups vulnerable to HIV acquisition. Gender minority (GM) individuals are understudied in clinical trials.

Setting:
HVTN 704/HIV Prevention Trials Network 085, a phase 2b randomized HIV prevention trial, enrolled MSM and transgender participants from Brazil, Peru, Switzerland, and the United States to receive an infusion every 8 weeks (10 total) of VRC01 30 mg/kg, VRC01 10 mg/kg, or placebo. Solicited adverse events (AEs) were recorded for 3 days after each infusion.

Methods:
Gender was defined by self-report and sex assigned-at-birth. Multivariate mixed logistic models were used to estimate the association between gender (cisgender men [CM] vs. GM participants [transgender women, transgender men, or another gender]) and solicited AE frequency and severity.

Results:
GM participants reported more solicited AEs than CM among all participants (adjusted OR 1.59, 95% CI: 1.20 to 2.10, P = 0.001) and among placebo recipients (1.72, 1.05 to 2.81, P = 0.031). The severity of solicited AEs (occurrence of grade 2 and higher event) did not significantly differ overall (1.83, 0.79 to 4.20, P = 0.174) or among placebo recipients (3.05, 0.76 to 12.32, P = 0.112). Grade 2 events were reported after 1% and 2% of total infusions among CM and GM participants, respectively. Grade 3–4 events were rare overall (<0.1%). Completion of 10 infusions was high (78.6%) and slightly higher in CM (79.2%) than GM participants (73%).

Conclusions:
This is the first report of associations between gender and solicited AEs after monoclonal antibody infusion. GM participants reported more events; severity was low. HIV prevention trials must engage and support GM individuals to best evaluate tolerability of novel agents.
A Novel Genetic Variation Identified in Patients With Orofacial Clefts
Authors: Yu Li-Ling , Zeng Qi , Yu Bao-Fu , Wei Jiao , Dai Chuan-Chang 
Published: December 2024

Background:
Orofacial clefts represent the most prevalent form of craniomaxillofacial deformity. Genetic factors are particularly significant in the development of orofacial clefts. This study was to investigate genetic variation in patients with orofacial clefts.

Methods:
This is a retrospective descriptive study. Whole-exome sequencing (WES) was conducted to identify mutated genes and mutation loci in patients with orofacial clefts. The identified mutation was validated through Sanger sequencing. Furthermore, functional analysis of the mutated gene was performed by utilizing a comprehensive database.

Results:
The results of WES showed IRF6 was mutated, and the variant locus was IRF6: NM_006147.4, IRF6 c.174+1delG chr1-209974583-ac-a. The variant locus was detected in the patient’s mother with orofacial clefts by Sanger sequencing. The Human Gene Database for variant gene shows that the IRF6 gene may be associated with craniomaxillofacial developmental abnormalities.

Conclusion:
The authors identified a novel locus within the IRF6 gene in a family with orofacial clefts that has not been previously reported. Functional analysis of the mutated gene suggests that this newly discovered mutation site may be associated with the genetic etiology of orofacial clefts in these patients. The findings will provide valuable data for elucidating the molecular mechanisms underlying orofacial clefts.

Level of evidence:
IV.
Observation of the
J≤7/2
low-spin states in
Fr213
populated in the electron capture of the
1/2−
ground state of
Ra213
Authors: Clisu C. , Andreyev A. N. , Nita C. R. , Lica R. , Naïdja H. , Andel B. , Antalic S. , Berry T. A. , Borge M. J. G. , Cocolios T. E. , Costache C. , Cubiss J. G. , De Witte H. , Fraile L. M. , Fynbo H. , Gadelshin V. M. , Granados C. , Greenlees P. , Heinke R. , Huyse M. , Lazarus I. , Leimbach D. , Marginean N. , Marginean R. , Marsh B. A. , Mihai C. , Mosat P. , Nacher E. , Negret A. , Ovejas J. D. , Page R. D. , Pascu S. , Perea A. , Podolyak Zs. , Pucknell V. , Rahkila P. , Rezynkina K. , Rossel R. E. , Sotty C. O. , Stan L. , Studer D. , Tengblad O. , Van Duppen P. , Vedia V. , Warr N. ,   The IDS Collaboration
Published: December 2024

A detailed level scheme of Fr126213 following the EC/β+ decay of the 1/2−Ra213 parent ground state was built in an experiment performed at the ISOLDE Decay Station, CERN. The fragmented total β decay strength favours the direct population of several low-spin (J≤7/2) excited states. The analysis of the γ-singles spectrum and γ−γ coincidences allowed us to identify many new γ-ray transitions and excited states in Fr213 up to about 3.6 MeV excitation energy. The spins and parities of the newly established levels, on top of the (7/21−) state, were mainly assigned based on the systematics of the N=126 isotones and further compared with shell-model calculations. The level scheme displays a structural pattern, with several groups of states with negative parity, emerging from the well-defined, simple, π(h9/25), π(h9/24f7/21) configurations or from their configuration mixing. The strength of the 2 transitions within the multiplets is compared with shell-model theoretical calculations performed with the and 208 effective interactions. A new (3/2−) isomer with a half-life of 26(3) ns has been identified. An upper limit of 35 ps was determined for the half-life of the first excited state, 7/2−. The possibility of a mixed M1+E2 character is discussed for the 7/21−→9/2gs− decay in Fr213, which leads to an l-forbidden nature of the πf7/2→πh9/2 transition.

Published by the American Physical Society
2024
Dislocation dynamics in Ni: Parameterizing dislocation trajectories from atomistic simulations
Authors: Anis Geraldine , Hudson Thomas , Brommer Peter 
Published: December 2024

We present a methodology using Differential Evolution Monte Carlo (DE-MC) to fit the parameters of an equation of motion to molecular dynamics (MD) trajectories of an a2〈110〉{111} edge dislocation in pure face-centered cubic (FCC) Ni, which is used as a model system. The motion of the edge dislocation under shear was observed using MD simulations with a classical effective potential, and the dislocation position was extracted. The parameters of interest were the effective mass, drag coefficient, and force experienced by the dislocation. Using DE-MC within a Bayesian framework, we estimated the joint posterior distribution of the parameters from the accepted samples produced by the DE-MC algorithm. The obtained distribution was then used to propagate the parameter uncertainties through the model, the equation of motion, which was used to predict the dislocation positions and velocities at the simulation timesteps as well as the uncertainty in the predictions. The mean fit was found to match the MD dislocation position data with a root mean square error (RMSE) of 0.2nm. We demonstrate how parameter distributions determined using the proposed methodology can be applied to obtain a mobility law for the class of dislocations studied with quantified uncertainties. This work is part of a longer-term study aiming to develop a surrogate model for precipitation strengthening, specifically dislocation-precipitate interactions, in Ni-based superalloys with uncertainty quantification. Accordingly, we also discuss the limitations of the selected model within this context and the necessary model extensions to overcome them.

Published by the American Physical Society
2024
Livestock production and poverty among rural farming households in Ethiopia
Authors: Umeokeke Nneji Ifeyinwa , Emokpae Osayi Precious , Adewale Ayoola A. 
Published: December 2024

PurposeThis study assessed the impact of livestock production on the poverty of rural households in Ethiopia.Design/methodology/approachData from the Ethiopia Living Standard Measurement Survey 2021/2022 was employed. The study assessed poverty using additional poverty aversion parameters (skewness and kurtosis) in the Foster–Greer–Thorbecke (FGT) and the conditional mixed process (CMP) model.FindingsThe result shows that 49% of the livestock farming households are poor. The poverty skewness and kurtosis indices show that the bulk of the population is far from the poverty line and poverty extremities exist. The CMP estimates show that age, household size, marital status, distance to market and capital region, income and agroecology influenced tropical livestock units. Also, an additional increase in tropical livestock significantly increases the household per capita expenditure.Social implicationsAlthough livestock production positively contributed to household expenditure, poverty still exists in all regions in Ethiopia. Interventions should consider local conditions and community needs in the value chain approach.Originality/valueThis study examined rural household poverty beyond the conventional headcount, gap and severity by including poverty skewness and kurtosis.Peer reviewThe peer review history for this article is available at https://publons.com/publon/10.1108/IJSE-05-2024-0415.
Upper-level leaders’ perceptions of integrating health and social care services after the structural reform in Finland: a qualitative study
Authors: Paatela Satu , Karreinen Soila , Huhtakangas Moona , Tynkkynen Liina-Kaisa 
Published: December 2024

PurposeIn Finland, a major health and social service system reform was implemented in 2023. The reform introduced macro-level organizational integration of health and social services as the responsibility for organizing the services was transferred from c. 300 municipalities to 22 well-being services counties which get their funding from the state. The purpose of this study is to describe different leadership actions to promote integration at the meso- and micro-levels of the service system after the macro-level organizational reform.Design/methodology/approachThe qualitative study utilized semi-structured interviews (n = 25) collected from the upper-level leaders of the well-being services counties. The study participants represented 11 well-being services counties in Finland. The data were collected in May–August 2023. Inductive content analysis was used for data analysis.FindingsFour leadership actions to promote integration at the meso- and micro-levels of the service system were identified: (1) service user-based leadership actions, (2) partnership-based leadership actions, (3) service system-based leadership actions and (4) knowledge-based leadership actions. Most of the interviewees combined several different leadership actions in their recount.Originality/valueThe study highlights important information of the focus points set for leading integration in the unique context of reforming health and social services. With this paper, we provide a new way of comprehending integration from the leadership point of view. The conceptualization through the different leadership actions may facilitate forming a shared vision for integration among leaders and managers.