bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Analysis of the Factors Related to the Quality of Work Life of the Workers at PT. Semen Indonesia Tuban Factory
Authors: Maulidhina Rachmawati 
Published: February 2020

Introduction: Quality of work life (QWL) is an essential concept related to the life of a worker. QWL is made to realize the balance between the workers’ needs and interests and the workload to ensure work satisfaction as well as the organization’s productivity. PT. Semen Indonesia is the biggest cement producing company in Java Island. The company manages the human resources to achieve job satisfaction by carrying out QWL programs. The aim of this research is to analyze the factors related to QWL that can lead to the workers’ QWL, especially to the packers and loader workers at PT. Semen Indonesia Tuban Factory. Methods: This research is completed by implementing the cross-sectional design with a qualitative approach. The population of this research is all workers in the packer and loader department Tuban IVth plant, as many as 80 people, while the sample consists of 45 workers chosen by the simple random sampling method. Seven identified factors from the literature review are the workers’ involvement, balanced compensations, a sense of security towards the work, occupational safety and health, career development, work relationships, and a sense of pride in the company. Results: Indicate that there are significant and positive relationships between all seven factors and the QWL. Conclusioan: that developing a non-financial compensation, socializing career development programs, and job guarantee will lead to job satisfaction and to ensure the organization’s productivity. Keywords: job satisfaction, packers and loaders, productivity, quality of work life
The prevalence of the sleep disturbances among the patients with substance use disorders
Authors: Vetrova M. V. , Kuchmenko D. N. , Genina I. N. , Goncharov O. V. , Rybakova K. V. , Semenova N. V. , Zubova E. Yu. , Kiselev A. S. , Neznanov N. G. , Krupitsky E. M. 
Published: February 2020

Background. There is evidence that sleep disorders may be significantly linked to the development of the substance use disorders (SUD). However, data about the prevalence of the sleep disturbances among patients with SUD in Russia are relatively limited.Aim. To evaluate the frequency of the sleep disturbances among patients (n = 196) with alcohol (ÀD, n = 102), opioid (ÎD, n = 55) and polysubstance dependence (PD, n = 39) seeking addiction medical care.Materials and methods. We conduct a cross-sectional study of sleep disturbances among patients in St. Petersburg in 2017–2018. The modified Insomnia Severity Index (ISI) was administered to assess sleep during different periods of time: lifetime, the past 12 months, and the past 30 days.Results. All groups demonstrated relatively high presence of different sleep disorders (range: 49.0–76.5% among 196). The sleep disturbances over the past 30 days were more common in the AD group (60.8– 73.5% among 102) with the early morning awakening as the most frequent complaint. In the PD group the prevalence of lifetime sleep disturbances was high (94.9–100.0% among 39), whereas insomnia disorders were relatively rare over the past 30 days. However, it was sleep disturbances over the past 30 days that were statistically significantly more often (p < 0,05) observed in the group of patients who actively consume narcotic substances (40.2–87.2%), compared with the group of patients in remission (0–16.7%).Conclusion. The results demonstrated the high prevalence of insomnia among patients with SUD and suggested that the remission have a positive effect on the symptoms of sleep disorders. Further studies of the association between sleep disturbances and SUD progression are needed.
Findings of the study of cognitive evoked potentials in persons exposed to radiation
Authors: Litvinchuk E. A. , Kantina T. E. , Burtovaya E. Yu. 
Published: February 2020

Introduction. After exposure to radiation, an increase in the long-term of cerebrovascular pathology is noted in exposed individuals. Cognitive impairments have a growing importance in the pattern of cerebrovascular diseases which significantly deteriorates social and medical forecast of a patient.The objective of the research is to study cognitive evoked potentials in exposed persons with chronic cerebral ischemia (CCI).Materials and methods. Two groups of patients were examined: the main group consisted of 69 persons exposed to radiation as a result of the “Mayak” PA activity, the comparison group included 110 unexposed residents of the Techa riverside settlements who were diagnosed with chronic cerebral ischemia. The following methods were used in the study: clinical, evaluation method of cognitive evoked potentials (EP), and statistical methods.Results. In the course of clinical examination, it was revealed that the number of people with organic cognitive impairment and syndrome of cognitive decline is statistically significantly higher in the group of the exposed persons with CCI (p < 0.001, p = 0.003, respectfully). It was stated that the studied groups were statistically significantly different in N1 peak latency (ð = 0.030), N2 – P3 inter-peak latency (p = 0.003), N2 – N3 inter-peak latency (p = 0.011).Conclusion. According to the results of clinical examination and study of cognitive EP, cognitive impairments are more expressed in the group of the exposed persons with CCI which is manifested in an increase in the number of patients with syndrome of cognitive decline and organic cognitive impairment in this group; in the change of a latency period of a number of components that characterize both the perception process and the very process of recognition and decision-making.
Capacidad discriminativa del deterioro funcional del Inventario de Personalidad DMS-5 Short Form en pacientes con trastorno por uso de sustancias
Authors: De la Rosa Cáceres Ana , Ramírez López Juan , Fernández Calderón Fermin , Lozano-Rojas Óscar M. , Moraleda-Barreno Enrique , Díaz-Batanero Carmen 
Published: February 2020

La evaluación de trastornos de personalidad comórbidos en pacientes consumidores resulta de especial relevancia en el ámbito clínico. Este trabajo analiza la capacidad discriminativa del Inventario de Personalidad PID-5 para detectar deterioro funcional en un grupo de pacientes con TUS. Además, se compara el uso de un criterio funcional y otro normativo para establecer los puntos de corte que representan un funcionamiento patológico en las facetas definidas en el Modelo Alternativo de Personalidad DSM-5. 178 pacientes con TUS asistentes a centros de tratamiento ambulatorio de adicciones cumplimentaron en PID-5 y el cuestionario para la Evaluación de la Discapacidad de la Organización Mundial de la Salud (WHODAS 2.0). El análisis de curvas ROC usando como criterio de discapacidad moderada a severa una puntuación superior a 25 en la WHODAS muestra valores AUC entre .50 y .78. 6 facetas no mostraron capacidad discriminativa de la discapacidad funcional: búsqueda de atención, grandiosidad, evitación de la intimidad, manipulación, afectividad restringida y perfeccionismo rígido. Los puntos de corte obtenidos usando el criterio funcional son superiores en las todas las facetas que resultan discriminativas del deterioro funcional respecto a los propuestos usando criterios normativos.El PID-5 tiene buena capacidad discriminativa de la disfuncionalidad evaluada por el WHODAS 2.0 en la mayor parte de facetas, especialmente en las facetas ligadas al dominio de afectividad negativa. Considerados globalmente, el uso de criterios normativos es posiblemente más adecuado para estudios epidemiológicos poblacionales, mientras que criterios funcionales podrían ser más útiles en muestras clínicas.
Collaboration with community connectors to improve primary care access for hardly reached people: a case comparison of rural Ireland and Australia
Authors: Wallace Carolyn , Farmer Jane , White Carolynne , McCosker Anthony 
Published: February 2020

Abstract
Background: This study presents a way for health services to improve service access for hardly reached people through an exploration of how staff can find and collaborate with citizens (referred to as connectors) who span socio-cultural boundaries in their community. The study explored the local socio-cultural contexts of connectors’ boundary spanning activities and if they are health related; boundary spanning occurring between connectors and health professionals at the interface of health systems and community; and the opportunities and barriers to actively seeking out and collaborating with community connectors to access marginalised and hardly reached people. Methods: We conducted a qualitative case comparison from rural Ireland and Australia. Following purposive snow-ball sampling techniques to recruit participants, semi-structured interviews were conducted with 34 community informants, 21 healthcare staff and 32 connectors. Transcripts were coded and analysed using an inductive approach to ascertain categories and overall themes. Results: We found a diverse sample of connectors relating to heterogenous, small and locally distinct groups of hardly reached people. Overall 26 connectors were active at the interface between health services and the community, with variation in how this occurred between cases. The majority (21) described one or more health related activities with hardly reached people. All connectors expressed a willingness to develop a relationship with local health services on issues they identified as relevant. Barriers to collaborations between connectors and health services related to bureaucracy, workload, and burnout. Conclusions: Collaborating with connectors has potential as one strategy to improve access to health services for hardly reached people. To enact this, health staff need to identify local socio-cultural boundaries and associated connectors, facilitate two-way connections at the boundary between health services and community and enable collaboration by attending to activities in the community, at the interface between health services and community, and within the health system.
Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function
Authors: Wu Jingtao , He Caimei , Bu Jie , Luo Yue , Yang Shuyuan , Ye Chengyan , Yu Silei , He Binsheng , Yin Yulong , Yang Xiaoping 
Published: February 2020

Abstract
Background：The intestinal epithelial barrier, which works as the first line of defense between the luminal environment and the host, once destroyed, it will cause serious inflammation or other intestinal diseases. Tight junctions (TJs) play a vital role to maintain the integrity of the epithelial barrier. Lipopolysaccharide (LPS), one of the most important inflammatory factors will downregulate specific TJ proteins including Occludin and Claudin-1 and impair integrity of the epithelial barrier. Betaine has excellent anti-inflammatory activity but whether betaine has any effect on TJ proteins, particularly on LPS-induced dysfunction of epithelial barriers remains unknown. The purpose of this study is to explore the pharmacological effect of betaine on improving intestinal barrier function represented by TJ proteins. Intestinal porcine epithelial cells (IPEC-J2) were used as an in vitro model. Results: The results demonstrated that betaine enhanced the expression of TJ proteins while LPS (1µg/mL) downregulates the expression of these proteins. Furthermore, betaine attenuates LPS-induced decreases of TJ proteins both shown by Western blot (WB) and Reverse transcription- polymerase chain reaction (RT-PCR). The immunofluorescent images consistently revealed that LPS induced the disruption of TJ protein Claudin-1 and reduced its expression while betaine could reverse these alterations. Similar protective role of betaine on intestinal barrier function was observed by transepithelial electrical resistance (TEER) approach. Conclusion: In conclusion, our research demonstrated that betaine attenuated LPS-induced downregulation of Occludin and Claudin-1 and restored the intestinal barrier function.
Cross-cultural adaptation and validation of the Slovenian version of the Core Outcome Measures Index for Low back pain
Authors: Topolovec Matevž , Vozlič David , Plohl Nejc , Vengust Rok , Vodičar Miha , Mannion Anne Frances 
Published: February 2020

Abstract
Background: To conduct a cross-cultural adaptation and validation of the Core Outcome Measures Index (COMI) in the Slovenian language, for use in patients with low back pain.
Methods: The English version of COMI was translated into Slovene following established guidelines. 353 patients with chronic low back pain were recruited from the Orthopedic clinic department of a tertiary care teaching institution. Data quality, construct validity, responsiveness, and test-retest reliability of the COMI were assessed.
Results: The questionnaire was generally well accepted with no missing values. The majority of items exhibited only mild floor and ceiling effects. Correlations with Oswestry Disability Index (ODI) were high (ρ = 0.76 between overall COMI and ODI scores), suggesting that the Slovene version of COMI had high construct validity. Additionally, the Slovene version of COMI successfully captured surgical patients’ improvement in their low back problem (indicator of responsiveness) and showed acceptable test-retest reliability (ICC = 0.86).
Conclusions: The Slovene version of COMI showed good psychometric properties, comparable to those of previously tested language versions. It represents a valuable instrument for the use in future domestic and multicenter clinical studies.
Keywords Cross-cultural adaptation ‧ Validation ‧ Core outcome measures index ‧ Low back pain ‧ Slovenian
Gap analysis of acoustic tracking data reveals spatial and temporal segregation in sympatric reef sharks
Authors: Williamson Michael J. , Tebbs Emma J , Dawson Terrence P , Curnick David J , Ferretti Francesco , Carlisle Aaron B , Chapple Taylor K , Schallert Robert J , Tickler David M , Block Barbara A , Jacoby David MP 
Published: February 2020

Abstract
Background
There are now a wide array of field and laboratory techniques available for gaining insight into the movement and behaviour of sharks. Although acoustic telemetry may lack the fine-scale resolution of some satellite technologies, the low cost and longer battery life make it a powerful tool for investigating elasmobranch behaviour. Here, we develop a novel approach to analysing acoustic telemetry data, using detection gaps to infer movement patterns to and from monitored reef habitats, to investigate spatial and temporal segregation between two sympatric shark species in a large remote MPA.

Methods
A total of 102 grey reef sharks (Carcharhinus amblyrhynchos) and 76 silvertip sharks (Carcharhinus albimarginatus) were fitted with long-term acoustic transmitters and tracked inside a large acoustic array of reef-based receivers in the British Indian Ocean Territory MPA, between 2014 and 2018. From the resulting dataset (768,081 detections), movements between receivers and recursive loops to the same receiver were identified. Using the durations of inter-receiver movements (i.e. detection gaps), individual behaviours were classified into ‘restricted’ or potential wider ‘out of range’ movements. Drivers of these movements were identified using network analysis, GLMMs and multi-model inference starting from an a priori set of explanatory variables.

Results
In general, silvertip sharks were more likely to undertake ‘out of range’ movements than grey reef sharks. ‘Out of range’ movements were more common at night compared to during the day, and during the wet season compared to the dry season. In addition, the difference in ‘out of range’ movements between the two species increased at night. These results suggest spatial and temporal segregation of movements between the two species.

Conclusions
We present a novel analysis of detection gaps from acoustic telemetry data to infer differential movement patterns and describe how species organise in space and time. Furthermore, this approach shows that acoustic telemetry gap analysis can be used for comparative studies, or combined, with other research techniques to better understand the functional role of sharks in reef ecosystems, moving towards more informed strategies for the conservation and management of the marine environment.
Tissue Adhesive for Wound Closure in enhanced-recovery Total Hip Arthroplasty: A Prospective, Randomized and Controlled Study
Authors: Kong Xiangpeng , Yang Minzhi , Cao Zheng , Chen Jiying , Chai Wei , Wang Yan 
Published: February 2020

Abstract
Background: We aimed to present our experience of adopting tissue adhesive as adjunct to standard wound closure in total hip arthroplasty (THA) and evaluate its performance.Methods: From September 2019 to November 2019, we prospectively enrolled consecutive patients who underwent simultaneous bilateral THA in this randomized and controlled study. Standard wound closure was applied on one side of hip and additional tissue adhesive on the other side at random. We collected and analyzed patients’ information, including age, gender, body mass index (BMI), diagnosis, postoperative length of stay (LOS), dressing changes, wound evaluation scores, wound-related cost and complications. Results: Thirty patients with simultaneous bilateral THA were enrolled in this study. During the hospital stay, the dressing change in hips with tissue adhesive was significantly less than that in the other hips (p=0.000). However, the wound-related cost in hips with tissue adhesive was significantly higher (p=0.000). At one-month follow up, patient-reported wound measurement of hips with tissue adhesive was significantly better than the other hips (p=0.004). Seventeen patients preferred tissue adhesive and only five patients preferred standard wound closure. Conclusions: Tissue adhesive could significantly reduce wound drainage and increase patient satisfaction, which can be an ideal adjunct to standard wound closure in enhanced-recovery THA.
Influence of the treatment used in inflammatory bowel disease on the level of protease activity
Authors: Dudzińska Ewa , Strachecka Aneta , Gil-Kulik Paulina , Kocki Janusz , Bogucki Jacek , Shemedyuk Natalya , Gryzinska Magdalena 
Published: February 2020

Abstract
Introduction: There is growing evidence that intestinal proteases have a role in the pathogenesis of gastrointestinal inflammatory diseases. IBD, which includes Crohn's disease (CD) and ulcerative colitis (UC), has an additional source of proteases represented by infiltrated and activated inflammatory cells. The aim of our study was to determine proteolytic system activity in patients with CD and UC. We limited the number of proteases tested by determining proteases active in acidic, neutral and alkaline pH.Material and methods: The study included 40 patients with IBD – 20 CD patients and 20 UC patients. Among the 20 CD patients, 17 were treated with aminosalicylates, 14 with azathioprine, and 4 with corticosteroids, while 8 patients were undergoing biological treatment. Among the 20 UC patients, 19 were treated with aminosalicylates, 8 with azathioprine, and 3 with corticosteroids. The optimal pH in which the enzymes were active was determined in acidic, neutral, and alkaline buffer environments. We prepared buffers of defined pH from 2.2 to 12.8, separated by 0.2 intervals and then determined proteolytic activity against substrates (gelatine, haemoglobin, ovalbumin, albumin, cytochrome C, and casein). Results: A decrease was observed in the activity of acid proteases (pH 5), alkaline proteases (pH 7), and neutral proteases (pH 7.6 and 8.6) in the groups of CD patients in remission in comparison with the active phase. In the group of patients with CD treated biologically, acid protease activity (pH 5.0) was lower than in CD patients not receiving biological treatment.Activity of neutral (pH 7.0) and alkaline (pH 7.6 and 8.6) proteases in the plasma of patients with UC in remission were lower in comparison to the active phase.Activity of acid (pH 5.0) and alkaline (8.6) protease inhibitors was higher in CD patients in the active phase in comparison to remission. In UC patients with exacerbation of the disease, the activity of alkaline (pH 8.6) protease inhibitors was increased compared to remission.Conclusions: 1. Our research may suggest that the immunomodulatory treatment used in IBD, aimed at reducing the level of leukocytes, may contribute to a reduction in protease activity.2. The decrease in the level of proteases in patients with CD and UC in remission may be a marker suggesting the patients’ response to the treatment.
Synthesis of CVD Diamond nanoparticles and Cytotoxicity evaluation in murine metastatic melanoma cells
Authors: Wachesk Cristiane Costa , Hurtado Carolina Guimarães , Falcão Rebeca , Tada Dayane Batista , Vasconcelos Getulio , Corat Evaldo José , Airoldi Vladimir Jesus Trava 
Published: February 2020

Abstract
Diamond nanoparticles (DNPs) have showed in vitro and in vivo biomedical applicability due to their low toxicity and biocompatibility. Recent studies have focused on the potential use of (DNPs) as suitable vehicles for improving drug delivery in cancer treatment. The advantages of DNPs lies in their high stability and small size compared to other carbon-based nanomaterials. In this work, CVD-diamond nanoparticles (CVD-DNPs) were synthesized and evaluated regarding their application as a new drug delivery platform for metastatic melanoma therapy. A new synthesis technique developed DNPs from CVD diamond thin film. This type of diamond has the same physical and chemical properties as a natural diamond: extreme hardness, excellent thermal conductivity, low coefficient of friction, biocompatibility, chemically inert for temperatures below 800 0 C, among others. The main objective of this study was to produce CVD-DNPs by laser ablation and to evaluate their cytotoxicity. A pulsed, ytterbium-doped fiber (Yb) was used to form DNPs in the pure aqueous medium (Milli-Q). The final suspension was obtained at high concentration of the CVD-DNPs and it was used to evaluate the cytotxicity in murine metastatic melanoma B16-F10 cells by using colorimetric assays. The characterization by FT-IR, X-Ray, DLS, RAMAN, SEM, and TEM demonstrated the successful synthesis of CVD-DNPs with a hydrodynamic diameter of 57 and 54 nm. In vitr o studies performed for 24h and 48h resulted in viability of 70-80% of cells incubated with CVD-DNPs at 250 μg/mL, which demonstrated a insignificant cytotoxic effect. Thus, these results suggest a potential use of CVD-DNPs as a drug delivery platform for antitumoral therapy.