bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinicopathologic characteristics and survivals in patients with uterine serous and clear cell carcinoma
Authors: FIRAT CÜYLAN Zeliha , ASLAN Koray , KORKMAZ Vakkas , ÖZ Murat , MEYDANLİ Mehmet Mutlu 
Published: March 2020

AbstractAim: We aimed to compare the clinicopathological characteristics and survivals between uterine serous carcinoma (USC) and uterine clear cell carcinoma (UCCC).Materials and Methods: The study population consists of women who were diagnosed with USC and UCCC according to the final pathology reports. Demographic, clinicopathological and survival data were collected and analyzed.Results: A total of 69 patients with USC and 36 patients with UCCC were included in the final analysis. Patients in the USC group tend to have more advanced stage disease compared to the patients in the UCCC group and this was statistically significant between the groups (61.1% vs 36.2%, respectively; p=0.015). Patients with USC were more likely to have omental metastasis (17/69 vs 2/36, p=0.016) and positive peritoneal cytology (25/69 vs 5/36, p=0.016). In the multivariate analysis, only positive peritoneal cytology remained as an independent prognostic factor for decreased disease free survival (DFS) for the entire cohort (HR 5.07, 95% CI 2.07-12.42; p&lt;0.001). Only positive peritoneal cytology was an independent prognostic factor for decreased overall survival (OS) for the entire cohort (HR 3.50, 95% CI 1.31-9.33; p=0.012) in the multivariate analysis.Conclusion: We concluded that positive peritoneal cytology was an independent prognostic factor for both DFS and OS in patients with USC and UCCC in the current study. Because of the high rate of omental metastasis in the USC group, we also suggest performing an omentectomy as a part of the comprehensive surgical staging surgery.
Mevsimsel farklılıkların Bell’s paralizisi sıklığı ve evresi üzerindeki etkileri
Authors: GÜNEŞ Akif , KARALI Elif 
Published: March 2020

Amaç:
Bu
çalışmada Bell’s paralizisi (BP) geçiren hastaların House-Brackmann Skorlama
(HBS) sistemine göre hastalık evrelerini değerlendirerek mevsimler arasında her
hangi bir farklılığın olup olmadığını değerlendirmeyi amaçladık.

Gereç
ve Yöntem: Üçüncü basamak bir hastanenin Kulak Burun Boğaz
polikliniklerinde muayeneleri yapılan ve BP olduğu tespit edilen, ağustos 2015-
ağustos 2019 tarihleri arasında, 20- 80 yaş aralığında 222 hastanın verileri
retrospektif olarak incelendi. HBS sistemine göre hastalık evreleri ve mevsimsel
farklılıkları değerlendirildi.

Bulgular:
Çalışmamıza 105’ i (%47,3) kadın, 117’ si (%52,7) erkek olmak üzere toplam 222
hasta dâhil edildi. Hastaların ortalama yaşı 39,28±19,20 olarak tespit edildi.
Çalışmamıza dâhil edilen hastalarda %36,5 ile en fazla 3. evrenin olduğu ve
%13,9 oranında ise en az evre 2 olduğu belirlendi. Yapılan istatistiksel
analizde mevsimsel farklılıklar ile evreler arasında anlamlı bir farklılığın
olduğu görülmektedir (p&lt;0.001). Sonbahar ve kış aylarında evre 4 ve evre 5
BP daha fazla görülmektedir.

Sonuçlar: Sonuç olarak BP hastalık evresi mevsimsel farklılıklardan etkilenmektedir. Ayrıca ülkemizde bölgesel farklılıkların BP evresi üzerindeki etkinliği
ile ilgili farklı bilimsel çalışmaların da yapılmasının literatüre katkı sağlayacağını düşünmekteyiz.
Dexmedetomidine as an adjuvant to infraorbital block in children undergoing cleft lip surgery – A clinical comparative study
Authors: B Sumalatha G , D Ravichandra R 
Published: February 2020

Regional nerve blocks provide excellent analgesia in children without adverse effects. However the duration of analgesia may be limited therefore addition of adjuvants can effectively prolong the duration of analgesia. Since alpha 2 agonist effectively prolong the duration of analgesia, we conducted a randomised double blind study to evaluate the effectiveness of dexmedetomidine as an adjuvant in infraorbital nerve block.: Eighty children of ASA grade 1 and 2, of either sex scheduled for cleft lip repair under general anaesthesia were allocated randomly into one of two equal groups (Group B and Group D, n=40). In both group sinfraorbital nerve block was performed with 1ml of solution on each side. The B group received bupivacaine 0.25% and the D group received b upivacaine 0.25% with 0.5µg/kg dexmedetomidine. The mean duration of analgesia and number of patients receiving rescue analgesia was recorded in both groups. The intraoperative hemodynamic parameters and postoperative sedation scores were recorded. For pain and sedation scores, Mann–Whitney U-test was used. Fisher’s exact test was used for comparison of categorical data. P ≤ 0.05 was considered as the level of statistical significance.Both groups were comparable in demographic profile. The mean duration of analgesia in Group D (733±49.15 minutes) was significantly longer compared to Group B (496±28.26) (p=0.001). There was a statistically significant difference in the number of patients receiving rescue analgesics in Group B (36) and Group D(8). The number of times of rescue analgesics in Group B and Group D was 3and 1 respectively, which was statistically significant. The intraoperative and postoperative hemodynamic HR was comparable in both groups (). The sedation score in the postoperative period did not differ between the two groups.
Comparison of levobupivacaine alone and levobupivacaine with dexmedetomidine in supraclavicular brachial plexus block: A prospective randomized clinical trial
Authors: Malawat Aman , Sachdev Sudhir , Sharma Vivek , Jethava Durga , Moin Khayyam 
Published: February 2020

Supraclavicular brachial plexus block is the most suitable mode of anaesthesia for various upper limb surgeries. Dexmedetomidine added to local anaesthetics shortens the onset time and prolongs the duration of block and post-operative analgesia in the brachial plexus block. However, there remains limited knowledge of its analgesic efficacy and duration in peripheral nerve and nerve plexus blockade. d: This prospective randomized double-blinded study was conducted with 60 patients of ASA physical status class I/II, scheduled for elective unilateral upper limb surgery. Patients were randomized into 2 groups of 30 each. All patients in Group L received a brachial plexus block with 29 ml of 0.5% levobupivacaine + 1ml of normal saline. Group LD received 29 ml of 0.5% levobupivacaine + 1ml of dexmedetomidine 1ml(100mcg). The primary objectives were the onset and duration of sensory and motor block. The onset of sensory and motor block was earlier in Group L (12.4 ± 3.1 min and 20.5 ± 3.8 min) than Group LD (15.9 ± 2.7 min and 22.1 ± 3.2 min), (P = 0.0000 and 0.0801). The duration of sensory and motor block was longer in Group LD (1198.0 ± 48.5 min and 1178.3 ± 41.4 min) than Group L (710.3 ± 87.3 min and 688.7 ± 86.6 min), (P =0.0000). The duration of analgesia was longer in Group LD (1222.0 ± 49.2 min) than Group L (726.3 ± 91.1 min), (P &#60; 0.0001). Dexmedetomidine added with levobupivacaine prolongs the duration of sensory as well as motor block in brachial plexus block using the supraclavicular technique with haemodynamic stability.
Relation between right ventricular function and the time of extubation after total repair of tetralogy of fallot in the pediatirc population
Authors: A Abdelhameed Gamal , I Ibraheem Waleed , M Abdeltawab Samar , H Armanios Simon 
Published: February 2020

To study the relation between the systolic and diastolic right ventricular (RV) function in relation to the time of extubation after total repair of tetralogy of Fallot (TOF) in a pediatric population. Prospective, descriptive, non-randomized study. Pediatric cardiac surgery unit at Ain Shams University Hospitals, Cairo, Egypt. The study was conducted from January 2016 to February 2018. A total of 60 patients having elective primary total repairs of TOF made up the study sample. The patients were divided into two groups based on the time of extubation: Group I included patients who were extubated 6 hours or more after the procedure, while Group II included patients who were extubated within the first 6 hours. Total corrective surgery involving open-heart surgery with cardiopulmonary bypass. Measurements and Main Results: Early outcomes of mortality and morbidity were evaluated. RV systolic and diastolic functions were evaluated in the routine echocardiography performed on the first and fifth postoperative days. Additionally, patients’ inotropic drug requirements during their intensive care unit (ICU) stays were calculated to produce the inotropic index for evaluation of postoperative low cardiac output. Group I contained 32 patients, while Group II contained 28. The mean ages in Group I and II, respectively, were 1.2 ± 0.8 years and 1.5 ± 0.9 years (p = 0.180). The mean weight in Group I and II, respectively, was 10.5 ± 2.5 kg and 9.86 ± 3.2 kg (p = 0.396). There were 20 (62.5%) males in Group I and 18 (64.29%) males in Group II (p = 0.886). Mortality was 2 cases (6.3%) in Group I and 1 case (3.6%) in Group II, with no statistical difference. Postoperative echocardiographic examination revealed significantly better RV functional parameters in Group II than in Group I.
Challenges in airway management of trauma patients: An update
Authors: Kumar Abhijit , Kohli Amit 
Published: February 2020

Trauma has been a widely studied subject in western world in past decade. Many international organizations have formulated guidelines regarding the management of victims who have threatened airway due to any kind of trauma. Indian subcontinent is following the western world in such situations but incidence and nature of trauma is different, moreover the availability of resources varies. This review article will highlight the topics like need for pre-hospital intubations, status of rapid sequence intubation, cricoid pressure, adjuncts for intubation and airway management of victims with trauma of special nature.“My heart and soul were wrecked; I was not sure whether my windpipe is going to make it or not”- Joshua Graham
A comparative study of intravenous febrinil vial (150mg/ml) vs intravenous paracetamol (1gm/100 ml) pint formulation for postoperative analgesia
Authors: Mittal Dave Urmi , R Vaghela Khyati , A Jadeja Chetna , R Chaudhari Dharti , J Gohil Jindal 
Published: February 2020

Paracetamol is used as an analgesic in mild to moderate pain over opioidsor NSAIDs due to lack of significant side effects. Intravenous Paracetamol is available as vial (150 mg/ml, 20 ml) and ready-to- use pint (1gm/100 ml) in market. Considering cost difference between the two formulations, we decided to conduct this study to assess analgesic efficacy against cost effectiveness between paracetamol vial and paracetamol pint.Sixty female patients, aged 18-35 years, American Society of Anaesthesiologist physical status I–III, posted for elective or emergency caesarean section under subarachnoid block were enrolled in the study. The patients were randomly allocated into two groups of 30 patients each. In Group A, IV P aracetamol (Febrinil vial,150mg/ml, by MANISH Pharmaceuticals) 6.5 ml (1gm) from vial diluted in 100 ml normal saline infused over 15 minutes and in Group B, IV Paracetamol 100 ml pint (1 gm/100 ml, by ABBOTT Pharmaceuticals) was given over 15 minutes at the time of skin closure followed by subsequent doses at 6 hourly interval in both the groups. Patients were observed for analgesia efficacy, requirement of rescue analgesia, hemodynamic stability and side effects if any. Cost effectiveness of both formulations was noted.Demographic profile, visual analogue score, number of rescue analgesia and haemodynamic were comparable in both the groups (p &#62; 0.05). No major complications were noted except nausea, vomiting, pain at injection site. But there was large difference in the cost of Paracetamol per dose between the two groups (33.66 rupees in group A vs 262 rupees in group B).We conclude that paracetamol is a safe and effective treatment option in post-caesarean pain without any major side effects. Considering total dose of 4 gm/24 hrs, Paracetamol vial formulation is more cost effective and equally efficacious analgesic as compared to ready to use Paracetamol pint.
Low dose spinal anaesthesia for caesarean section in parturients having pregnancy induced hypertension: Effect on haemodynamicre sponse and vasopressor requirement: A prospective randomized double blind case control study
Authors: Navaria Rajeev , Kumar Verma Virendra , Naithani Udita , Goyal Anjuri , Aditya Das Saurav 
Published: February 2020

Currently, the safety of spinal anaesthetic techniques is well established for caesarean section in pregnancy induced hypertension (PIH) patient. Addition of fentanyl to local anaesthetic allows achievement of adequate anaesthesia with lower dose of local anaesthetic in spinal anaesthesia, thereby reducing the occurence of hypotension and need for vasopressor. A prospective, randomized, double blind, case control study was carried out in 80 parturients having PIH undergoing caesarean section in spinal anaesthesia were randomized into 2 groups depending on intrathecal drug received by them as Group C (Conventional dose group- received hyperbaric bupivacaine 10 mg)and Group L{low dose group, hyperbaric bupivacaine (7.5 mg) with fentanyl (25 mcg)} and compared regarding sensory- motor block characteristics, incidence of hypotension (fall in MAP &#62; 25% from baseline) vasopressor requirement Phenylephrine and Ephedrine. Patient in Group L had significantly less number of hypotension episodes as compared to Group C(20 vs 31, p= 0.011). Hence vasopressor requirement was also significantly less in Group L than in Group C [Phenylephrine (1600 mcg vs 2500 mcg, p=0.044), Ephedrine (66 mg vs 18 mg, p= 0.030)].Low dose spinal anaesthesia using 7.5 mg hyperbaric bupivacaine with 25 mcg fentanyl seems to be superior alternative to conventional dose of 10 mg hyperbaric bupivacaine for caesarean section in parturients having pregnancy induced hypertension, because it was associated with better hemodynamic stability, reduced vasopressor requirement.
Clinical investigation on the analogy between the ketofol (Amalgamation of Ketamine and Propofol) and ketamine and midazolam for procedural sedation – A single blinded study
Authors: Kumar Donda Rajesh , Reddy Annareddy Gangadhara , Nattala Ramudu , Usha Rani M 
Published: February 2020

Decades of research for an ideal sedative agent that could provide both sedation and analgesia with minimal side effects to the patients has failed to find one. Research was then shifted to finding combination of drugs which could suffice the ideal sedative agent. Of these Ketofol showed promising results.Aim of this study is to “Assess the efficacy and safety of propofol and ketamine amalgamation (ketofol) and comparing the superiority over ketamine and midazolam combination for procedural sedation”. In this prospective randomized single blind study, 50 patients between 15 to 60 years of both males and females, ASA Grade I and Grade II were allocated into two groups. Patients in group 1 received ketofol and group 2 patients received ketamine and midazolam. The comparison between the two groups was done using Two-Sample T-Test, With the help of SPSS version 15.0 Statistical calculator, sample size calculated = 5 to 17, and actual power calculated with this sample size was 0.990 to 0.997 which shows significance of the study.: The study showed statistically significant (p &#60;0.005) difference in HR, DBP, SBP, MBP and recovery time between two groups. Group 1 patients showed stabilized parameters and rapid recovery time than group 2 patients Ketofol is safe and efficient sedative combination which can be utilized in emergency department, daycare and OT settings with comfort, ease and without any complications. It is close to ideal sedative agent.
A comparative study to evaluate the effect of 8% sevoflurane compared to 1% Propofol for insertion of laryngeal mask airway in adult patients -A prospective, randomised & controlled study
Authors: Vishnu Mahesh Babu Batchu , Appalaraju Nellimarla , Prem Sagar T 
Published: February 2020

The airway management during the general anaesthesia is mainly done using laryngeal mask airway. The anaesthesia that is used for this purpose is either propofol or sevoflurane supplied through inhalational route for painless insertion. Hence, the study was conducted with the aim of comparing 8% sevoflurane and 1% Propofol with regard to efficacy and associated complications. This prospective experimental study included adult subjects who were undergoing minor surgeries. The subjects were equally distributed into two groups. The Group-1 received propofol 2-2.5 mg/kg body weight and Group-2 received 8% sevoflurane. The study outcomes were determined induction characteristics such as loss of verbal contact, eyelash reflex, jaw relaxation and some attempts for insertion were assessed. The other parameters that were recorded were grading of the parameters, blood pressure, and heart rate and associated complications. A total of 60 participants were included in the study. Propofol took a lesser time for Induction characteristics as compared to that of sevoflurane. It was observed that propofol was associated with fall in heart rate and blood pressure and more rate of complications. Faster induction was observed in Propofol while good hemodynamic stability was associated with Sevoflurane.
Addition of dexmedetomidine to ropivacaine for lower limb orthopaedic surgery under spinal anaesthesia to study its effect on block characteristics- An observational study
Authors: Ahluwalia Pallavi , Fakri Taqui 
Published: February 2020

Spinal anaesthesia provides faster onset, effective sensory and motor block, adequate muscle relaxation and profound analgesia simply by injecting a small amount of local anaesthetic drug directly into CSF in subarachnoid space. This present study was conducted to assess the efficacy of Dexmedetomidine as an adjuvant to Ropivacaine in terms of duration of sensory and motor block, post-operative analgesia and side effects in lower limb orthopedic surgeries.: This prospective study was done on 50 ASA I/II patients of age 18-60 years undergoing spinal anaesthesia for lower limb orthopaedic surgery. In this study patients received an intrathecal injection of 22.5 mg Ropivacaine (3ml Ropivacaine 0.75%) & 5μg dexmedetomidine i.e. 0.5 ml. Onset of sensory/motor block, duration of sensory/motor block, duration of analgesia and side effects were noted. Post-hoc bonferroni test was used for intercomparison of mean HR and MAP and significant difference was observed between them. The mean onset of Sensory Block was 3.51±0.50, mean Time to achieve maximum height of block (Minutes)was 10.63±0.59, Time to onset of regression at the level of L1 (minutes) was 187.45±22.61, mean Motor Block-Time to modified Bromage score 3 was 6.12±0.84 and Motor Block - Time to complete recovery (minutes) was 173.14±34.26. The mean Time to complete analgesia (in minutes) was 401.06±16.91 and mean Time to effective analgesia (in minutes) was 415.25±16.70. The present study concludes that addition of dexmedetomidine with Ropivacaine provides faster onset of sensory/motor block.
Attenuation of sympathoadrenal response to direct laryngoscopy and intubation using 0.25mg/kg injection labetalol
Authors: Y Srinivas V , S Sindhu 
Published: February 2020

: Direct laryngoscopy and endotracheal intubation evokes autonomic disturbances in the form of tachycardia, raise in blood pressure, intracranial, and intraocular pressure.Thus the present study was undertaken to evaluate the efficacy of injection Labetalol 0.25mg/kg body weight in the attenuation of sympathoadrenal response to direct laryngoscopy and endotracheal intubation.: The study was conducted on 60 participants belonging to ASA grade 1 or 2 aged between 18 – 55 yrs undergoing elective surgeries under general anaesthesia. The study population was randomly divided into 2 groups with 30 subjects in each group.Group LAB (Labetalol group) – received 0.25mg/kg body weight diluted upto 10ml with normal saline intravenously, over 10minutes using a syringe pump, given 10minutes before induction.Group CR (Control) received 10ml of normal saline intravenously.The study drug was administered over 10 minutes using syringe pump followed by induction with inj Thiopentone 5mg/kg body weight and inj vecuronium 0.1mg/kg body weight three minutes prior to laryngoscopy and intubation. HR(Heart rate), Systolic arterial pressure, diastolic arterial pressure, MAP(mean arterial pressure) were recorded at basal, 2 minutes, 5 minutes, 8 minutes after study drug infusion, before induction, after induction, 1, 2, 3, 5, 10, 15 minute after laryngoscopy and intubation.: The result showed statistically significant (p&#60;0.05) decrease in Heart rate, Systolic arterial Pressure, Diastolic arterial pressure and Mean arterial pressure in Group LAB compared to Group CR at all the time intervals.In the present study, it was found that inj Labetalol 0.25mg/kg body weight had effectively attenuated the sympathoadrenal response to laryngoscopy and intubation.
A comparative study of intramuscular dexmedetomidine alone and intramuscular dexmedetomidine with intravenous fentanyl on hemodynamic response to laryngoscopy and endotracheal intubation for ear surgery under general anesthesia
Authors: Shah Ayush , Patel Neepa , J Pandya Malti 
Published: February 2020

Dexmedetomidine, a potent α2-adrenergic agonist with its sedative, anxiolytic, analgesic and sympatholytic property ; is an ideal agent for premedication. The intravenous bolus is associated with bradycardia and hypotension; hence we studied the intramuscular route for hemodynamic stability.: Sixty adult patients of ASA physical status I and II, aged between 18-60 years, posted for ear surgery received intramuscular dexmedetomidine 2.5µg/kg 60 minutes prior to induction of anesthesia as premedication in recovery room with either injection saline bolus in group D (n=30) or intravenous fentanyl 1.5 μg/kg group DF (n=30) 2 mines before induction in operation theatre. Standard induction technique was used. Sedation score and hemodynamic changes during laryngoscopy were recorded. During laryngoscopy and intubation, transient rise in Heart Rate and Mean arterial pressure seen in Group D as compared to Group DF; (p &#60;0.05); Heart Rate and MAP in group D returned to pre-induction values within 3 minutes of laryngoscopy. No patient suffered from profound sedation at any point of observation. This study provides evidence that intramuscular dexmedetomidine alone acts as effective premedication agent with attenuation of stress response; and combination of Intramuscular dexmedetomidine and intravenous fentanyl not only attenuate but also prevents stress response to laryngoscopy and tracheal intubation.