bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram to Predict Poor Outcome after Mechanical Thrombectomy at Older Age and Histological Analysis of Thrombus Composition
Authors: Meng Longyan , Wang Haichao , Yang Hua , Zhang Xiang , Zhang Quanbin , Dong Qiong , Shu Zhongwen , Chen Liuwei , Gong Li , Zhao Yanxin 
Published: December 2020

An easy scoring system to predict the risk of poor outcome after mechanical thrombectomy among the elderly is currently not available. Therefore, we aimed to develop a nomogram for predicting the probability of negative prognosis in aged patients with acute ischemic stroke undergoing thrombectomy. In addition, we sought to investigate the association between histological thrombus composition and stroke characteristics. To this end, we prospectively studied a developed cohort using data collected from a stroke center from November 2015 to December 2019. The main outcome was functional independence, defined as a modified

Rankin

Scale

score
≤
2

at 90 days following a mechanical thrombectomy. A nomogram model based on multivariate logistic models was generated. The retrieved thrombi were stained with hematoxylin and eosin and assessed according to histological composition. Our results demonstrated that

age
≥
72

years

was independently associated with poor outcome. A total of 304 participants completed the follow-up data to generate the nomogram model. After multivariate logistic regression, five variables remained independent predictors of outcome, including older age, hemorrhagic transformation, thrombolysis in cerebral infarction score, National Institute of Health Stroke score, and neutrophil-to-lymphocyte ratio, and were used to generate the nomogram. The area under the receiver-operating characteristic curve of the model was 0.803. The clots from elderly subjects with large-artery atherosclerosis, anterior circulation, and successful recanalization groups had a higher percentage of fibrin compared to those of younger patients. This is the first nomogram to be developed and validated in a stroke center cohort for individualized prediction of poor outcome in elderly patients after mechanical thrombectomy. Clot composition provides valuable information on the underlying pathogenesis of oxidation in older patients.
Risk of Hepatocellular Carcinoma Remains High in Patients with HBV-Related Decompensated Cirrhosis and Long-Term Antiviral Therapy
Authors: Zhu Dong-Mei , Xie Jing , Ye Chun-Yan , Qian Mei-Yun , Xue Yuan 
Published: December 2020

Background. This study aimed to evaluate the risk factors of HCC development in patients with hepatitis B virus (HBV)-related DC and who underwent long-term antiviral therapy. Methods. Data from 308 patients with HBV-related DC and long-term antiviral therapy were collected and retrospectively reviewed. Cox regression analysis was used to analyze independent risk factors of HCC development. Results. Data from 129 patients with definite records were analyzed. The median follow-up time was 5 years (range, 1 to 8 years). At the end of the follow-up, 41 (31.8%) patients developed HCC, and the time from DC diagnosis to HCC incidence who received antiviral therapy was 4.4 years (range, 1–7 years). The incidence of HCC was higher in males (30/78, 38.5%) than in females (11/51, 21.6%) (

P

= 0.04). Patients who developed HCC were significantly older than those who did not develop HCC (

P

< 0.01). The incidence of HCC in patients receiving nucleoside analogues, nucleotide analogues, and combination therapy was 34.7%, 38.1%, and 33.3%, respectively, and the difference showed no significant differences (

P

= 0.95). Multivariate Cox regression analysis demonstrated that male gender and age ≥50 years are independent risk factors of HCC development (OR = 2.987 and 2.408; 95% CI (1.301–6.858) and (1.126–5.149);

P

= 0.01 and 0.02, respectively). Conclusion. The risk of HCC remains to be high in patients with HBV-related DC, especially in males aged ≥50 years.
Reversing the Gaze? Or Decolonizing the Study of the Qurʾan
Authors: Rizvi Sajjad 
Published: December 2020

Abstract
Taking as the starting point, Majid Daneshgar’s Studying the Qurʾan in the Muslim Academy, I argue that the political and intellectual contexts for the study of Islam and indeed the Qur’an cannot be ignored whether the study is conducted in the “Western” or the “Muslim” academy. The construction of the categories of religion and scripture arise out of practices of colonialist knowledge; positionality of the author cannot be eliminated from the interrogative gaze. Beginning with that critique, I suggest some possible ways in which we can decolonize the study of the Muslim scripture and its experience for Muslims.
Strategic Litigation in South Africa and Uganda: Shared Perspectives and Comparative Lessons
Authors: Mubangizi John C 
Published: December 2020

Abstract
The South African Constitution, particularly its Bill of Rights, is regarded as one of the most progressive in the world. The Ugandan Constitution, adopted around the same time as its South African counterpart, also has a Bill of Rights. Lawyers and advocacy groups in both countries have taken advantage of their constitutions to challenge the government to enforce several rights ranging from health care services, education, water and sanitation, to housing and social security, albeit at a lower scale and with less impact and significance in Uganda than South Africa. The purpose of this paper is to discuss and determine the constitutional impact of strategic litigation in South Africa and Uganda. The paper begins with a conceptual context of strategic litigation. The specific reasons for the choice of the two countries are highlighted before focusing, in a comparative way, on some relevant organizations and the various court decisions that have emanated from strategic litigation in both countries. The paper identifies similarities and differences between Ugandan and South African approaches to strategic litigation. Conclusions are then made after highlighting the comparative lessons that both countries can learn from each other, but also what other African states can learn from these two countries’ experiences.
Use of the End to End Anastomotic Stapler From Above for Difficult Pelvic Surgery for Distal Rectal Disease
Authors: Amersi Farin F. , Wright Byron , Silberman Allan W. 
Published: December 2020

Introduction Transabdominal utilization (TAU) of the end to end anastomotic (EEA) stapler in low anterior resection (LAR) for rectal cancer is an excellent alternative to the most widely performed techhnique. Methods We performed a retrospective analysis of a prospectively maintained database which obtained data on 104 patients with rectal disease who underwent EEA-assisted LAR with TAU. Records of all patients were used to evaluate demographics, complications, tumor location, margin status, postoperative complications, clinical sphincter function, adjuvant or neoadjuvant treatment, disease stage, and survival. Results Of the 104 patients, 48% were women with a mean age of 64 years (range 34-85 years). The average tumor location was 8 cm above the dentate line, and the mean tumor distance from the distal margin was 1.9 cm. All distal margins in cases for patients with rectal cancer were negative. Hospital length of stay averaged 8.7 days (6-15 days). There were no anastomotic complications (leaks, bleeding, or obstruction), and there were no leaks at the separate colotomy site. All patients have had normal postoperative sphincter function. Conclusion Transabdominal utilization of the EEA stapler in LAR for colorectal carcinoma is an alternative to the conventional approach and may be advantageous in avoidance of the lithotomy position with potential nerve injury, risk of deep venous thrombosis, and stapler-induced sphincter trauma.
Goal-Directed Fluid Therapy and Postoperative Outcomes in an Enhanced Recovery Program for Colorectal Surgery: A Propensity Score-Matched Multicenter Study
Authors: Zorrilla-Vaca Andres , Mena Gabriel E. , Ripolles-Melchor Javier , Abad-Motos Ane , Aldecoa Cesar , Lorente Juan Victor , Ramirez-Rodriguez José M. , Grant Michael C. 
Published: December 2020

Introduction Goal-directed fluid therapy (GDFT) has increasingly been utilized in major surgery as a key component to ensure fluid optimization and adequate tissue perfusion, showing improvements in the rate of morbidity and mortality under conventional care. It is unclear if patients derive similar benefit as part of an enhanced recovery program (ERP). Our group sought to assess the association between GDFT and postoperative outcomes within an ERP for colorectal surgery. Methods A propensity score-matched analysis, based upon demographic characteristics, comorbidities, and ERP components, was utilized to assess the association between GDFT and outcomes in a multicenter prospective ERP for colorectal surgery cohort study. Outcomes included pulmonary edema, acute kidney injury (AKI), ileus, surgical site infection (SSI), and anastomotic dehiscence. The calipmatch module was used to match patients who received GDFT to non-GDFT in a 1‐to‐1 propensity score fashion. Results A total of 151 matched pairs were included in the analysis (n = 302, 23%). Both groups had comparable baseline demographics, as well as similar rates of compliance with enhanced recovery after surgery (ERAS) components. Goal-directed fluid therapy patients received significantly more colloid (237 ± 320 mL vs. 140 ± 245 mL, P < .01) than non-GDFT counterparts. Goal-directed fluid therapy was not associated with improved rates of postoperative AKI (odds ratios (OR) 1.00, 95% confidence intervals (CI) .39-2.59, P = 1.00), ileus (OR 1.40, 95% CI .82-2.41, P = .22), SSI (OR 1.06, 95% CI .54-2.08, P = .86), or length of hospital stay (LOS) (10.8 ± 8.9 vs. 11.1±13.2 days, P = .84). Conclusions There was no associated between GDFT and major postoperative outcomes within an ERAS program for colorectal surgery. Additional large-scale or pragmatic randomized trials are necessary to determine whether GDFT has a role in ERP for colorectal surgery.
A Cohort Study Assessing the Association Between Body Composition Parameters and Symptomatic Hypocalcemia After Total Thyroidectomy
Authors: Celik Suleyman U. , Konca Can , Genc Volkan 
Published: December 2020

Background Postoperative hypocalcemia is one of the major concerns following thyroidectomy and the most frequent cause of prolonged hospital stay. The aim of this study was to evaluate the relationship between body composition parameters and symptomatic hypocalcemia following total thyroidectomy. In addition, the effects of disease- and patient-related factors on hypocalcemia were investigated. Methods A total of 144 patients were prospectively included between March 2014 and September 2017. Patients were divided into 2 groups according to the presence or absence of clinical symptoms of hypocalcemia. Subsequently, the relationship between body composition parameters and hypocalcemia was evaluated. Results Postoperative hypocalcemia-related symptoms occurred in 28 patients (19.4%). Permanent hypocalcemia was not encountered in any patient. Patients with hypocalcemic symptoms were more likely to have nodules ≥40 mm (39.3% vs. 17.2%, P = .011), retrosternal goiters (25.0% vs. 7.8%, P = .017), central lymph node dissection (LND) (32.1% vs. 11.2%, P = .015), and parathyroid autotransplantation (28.6% vs. 3.4%, P < .001) than those without symptoms. However, no differences were observed in the body composition parameters between symptomatic and asymptomatic patients. On multivariate analysis, lower preoperative intact parathyroid hormone (iPTH) levels (odds ratios (ORs) .96, 95% confidence intervals (CIs) .93-.99), the presence of retrosternal goiters (OR 10.26, 95% CI 2.23-47.14), central LND (OR 16.05, 95% CI 3.90-66.07), and parathyroid autotransplantation (OR 36.22, 95% CI 6.76-194.13) predicted hypocalcemia. Discussion This study demonstrates that patients with lower preoperative iPTH levels, retrosternal goiters, central LND, and parathyroid autotransplantation are at an increased risk of developing clinical symptoms of hypocalcemia. Body composition parameters have no effect on the incidence of hypocalcemia after total thyroidectomy.
Intracranial hemorrhage with direct oral anticoagulants in patients with brain metastases
Authors: Leader Avi , Hamulyák Eva N. , Carney Brian J. , Avrahami Maya , Knip Jelijn J. , Rozenblatt Shira , Beenen Ludo F. M. , Yust-Katz Shlomit , Icht Oded , Coppens Michiel , Raanani Pia , Middeldorp Saskia , Büller Harry R. , Zwicker Jeffrey I. , Spectre Galia 
Published: December 2020

Abstract
Direct oral anticoagulants (DOACs) are increasingly prescribed in treatment of cancer-associated thrombosis, but limited data exist regarding safety of DOACs in patients with brain metastases. We aimed to determine the incidence of intracranial hemorrhage (ICH) in patients with brain metastases receiving DOACs or low-molecular-weight heparin (LMWH) for venous thromboembolism or atrial fibrillation. An international 2-center retrospective cohort study was designed. Follow-up started on the first day of concomitant anticoagulation and brain tumor diagnosis. At least 2 brain imaging studies were mandated. The primary outcome was the cumulative incidence of any spontaneous ICH at 12-month follow-up with death as a competing risk. Major ICH was defined as spontaneous, ≥10 mL in volume, symptomatic, or requiring surgical intervention. Imaging studies were centrally reviewed by a neuroradiologist blinded for anticoagulant type. PANWARDS (platelets, albumin, no congestive heart failure, warfarin, age, race, diastolic blood pressure, stroke) score for prediction of ICH was calculated. We included 96 patients with brain metastases (41 DOAC, 55 LMWH). The 12-month cumulative incidence of major ICH was 5.1% in DOAC-treated patients and 11.1% in those treated with LMWH (hazard ratio [HR], 0.45; 95% confidence interval [CI], 0.09-2.21). When anticoagulation was analyzed as a time-varying covariate, the risk of any ICH did not differ between DOAC- and LMWH-treated patients (HR, 0.98; 95% CI, 0.28-3.40). PANWARDS score was not associated with ICH risk. This international 2-center study suggests comparable safety of LMWH and DOACs in patients with brain metastases.
Factors associated with food taboos among pregnant women in the Dimma district, Gambella, Ethiopia
Authors: Teshome Ageze , Zinab Beakal , Wakjira Tekle , Tamiru Dessalegn 
Published: December 2020

Background/Aims A food taboo is a food or drink that people are prohibited from consuming, often as a result of an incorrect perception of the food or for religious reasons, especially in low- and middle-income countries. During pregnancy, many women are subject to food taboos that can have deleterious effects on the fetus. This study aimed to assess the magnitude ofand factors associated with food taboos among pregnant women in Dimma district, Gambella, Ethiopia. The findings of this study can advise how to address the cultural malpractices that affect dietary behaviours of pregnant women, especially in developing countries like Ethiopia. Methods A facility-based cross-sectional study was conducted among 276 pregnant women from March 6 to May 8 2019, in Dimma district, Gambella. Data were collected using a pretested interviewer-administered structured questionnaire and key informant interviews. A total of 14 key informant interviews were conducted. Descriptive statistics and multivariable logistic regression models were fitted to isolate independent predictors of food taboo practices. All tests were two sided and P<0.05 was used to set statistical significance. Qualitative data were audio taped and transcribed verbatim. Results Over one-third (34.7%) of the study participants restricted themselves from at least one food item during pregnancy. Common food taboos were fruits, cereals, honey, sugarcane, garden cress, mustard seed and yam. The main reasons behind food taboos were fear of maternal and fetal complications, including abortion, cardiac problems and anaemia. Food taboo practice was more common in participants aged ≥25 years (adjusted odds ratio=2.72; P=0.002), who had only attended primary education (adjusted odd ratio=2.56, P=0.019) and had a gestational age ≥7 months (adjusted odds ratio=4.33, P<0.001). Conclusions More than one-third of pregnant mothers were practicing food taboos during pregnancy in Dimma Woreda, Gambella region, which was significantly associated with older participants and a lack of formal education. Therefore, intensive nutrition education should be given by both government and non-government organisations, focusing on pregnant women.
The Pallof Press
Authors: Mullane Michael , Turner Anthony N. , Bishop Chris 
Published: December 2020

ABSTRACT
The use of core training is very common in the field of strength and conditioning. The Pallof press is one such exercise, which is considered a transverse plane or trunk rotation exercise. The use of this trunk-based exercise is implemented in strength and conditioning programs to aid in core stability. Exercise technique and the benefits of this exercise have been described in this article. The key coaching points for each position along with a progression and regression continuum for the Pallof press have also been outlined. This continuum along with the suggested programming can be used by practitioners to aid in lumbopelvic stability.
Análisis de la Sentencia de la Mayoría del Tribunal Constitucional en el caso de la Pontificia Universidad Católica del Perú y la herencia de don José de la Riva Agüero
Authors: Rubio Correa Marcial 
Published: December 2020

Análisis de la calidad jurídica de la Sentencia del Tribunal Constitucional, que resolvió declarar infundado el recurso de agravio constitucional que había interpuesto la PUCP; se señala el argumento de la sentencia de la mayoría del tribunal como inválido e imposible de ser tomado en cuenta. Además se señala que la determinación de si un acto jurídico privado está sometido a la modalidad de cargo, no es un asunto que compete al Tribunal Constitucional sino a los juzgados ordinarios, que ya tienen conocimiento del proceso respectivo. Del mismo modo, se expone que la mayoría del Tribunal, por lo dicho, se ha avocado inconstitucionalmente a la resolución de este aspecto del caso por tanto se declara tal opinión como inválida.
hsa_circ_0000231 promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway
Authors: Zhang Wei , Wang Bo , Yang Yang , Zhang Zhen , Wang Quan , Zhang Haoran , Jiang Kewei , Ye Yingjiang , Wang Shan , Shen Zhanlong 
Published: December 2020

Abstract
Background and aim Circular RNAs (circRNAs) have emerged as vital regulators of the initiation and progression of diverse kinds of human cancers. This study aimed to investigate the role of circRNAs in colorectal cancer (CRC).Methods The expression profiles of circRNAs in five pairs of CRC tissues and adjacent normal tissues were analyzed using microarray. Quantitative real-time polymerase chain reaction, in situ hybridization, and BaseScope Assay were used to determine the level and prognostic values of hsa_circ_0000231. Then, in vitro and in vivo functional experiments were performed to investigate the effects of hsa_circ_0000231 on cell proliferation. Mechanistically, fluorescence in situ hybridization, dual-luciferase reporter assay, and RNA pull-down and RNA immunoprecipitation experiments were performed to confirm the interaction between hsa_circ_0000231 and Insulin-like growth factor 2 mRNA-binding protein 3(IGF2BP3) or has_miR-375. Results The expression of hsa_circ_0000231 was upregulated in CRC primary tissues, which indicated poor prognosis of patients with CRC. The results demonstrated that hsa_circ_0000231 could promote CRC cell proliferation as well as tumorigenesis in vitro and in vivo. The mechanistic analysis showed that hsa_circ_0000231 might, on the one hand, act as a competing endogenous RNA of miR-375 to promote cyclin D2 (CCND2) and, on the other hand, bind to the IGF2BP3 protein to prevent CCND2 degradation. Conclusion The findings suggested that hsa_circ_0000231 facilitated CRC progression by sponging miR-375 or binding to IGF2BP3 to modulate CCND2, implying that has_circ_0000231 might be a potential new diagnostic and therapeutic biomarker of CRC.
Willingness to forgiveness as a predictor of mental health and psychological resilience of displaced persons from the zone of military conflict in Eastern Ukraine
Authors: Kravchuk Svitlana Leontivna 
Published: December 2020

The article is devoted to the problem the characteristics of willingness to forgiveness in displaced persons from the conflict zone. The concepts of forgiveness and psychological resilience are considered. The article examines the characteristics of willingness to forgiveness as a predictor of mental health and psychological resilience of displaced persons from the conflict zone.
The presented findings should be taken into account by persons offering professional support for such group of persons.
Development of emotional intelligence in students with special educational needs
Authors: Garbenis Simas , Geležinienė Renata , Šiaučiulytė Greta 
Published: December 2020

The aim of the study is to analyse teachers’ opinion about the development of emotional intelligence in students who have special educational needs in inclusive schools. The method of the questionnaire survey was chosen to achieve the research aim. The study employed two developed questionnaires based on the principle of Likert scale (1-5). The questionnaires were developed for teachers according to the parts of the structure of trait emotional intelligence for students aged 7 to 12 and 13 to 17 years. Questionnaires potentially reveal teachers’ opinion about several aspects of emotional intelligence development: how and how often teachers assess, organize targeted and non-targeted educational activities for individual parts of the structure of students’ emotional intelligence and promote awareness of their importance. After conducting the research, it was found that the development of parts of the structure of emotional intelligence was carried out differently depending on students’ age. Differences were recorded both between the developed parts of the structure and between applied educational activities. Both statistically significant and insignificant research data were obtained and it was found that the development of emotional intelligence for younger students was more oriented to their inner self-knowledge; while for older students, to the aspects of socialization.
Professional experiences of on-call specialists in the field of violations of children’s rights
Authors: Malinauskienė Daiva , Igorytė Aistė 
Published: December 2020

The article analyses the content of the activity of child rights protection on-call specialists, their experiences related to the representation of the child and his/her interests. In Lithuania, this position is new and it emerged after the reform of the child rights protection system, which was caused by the increase in cases of violence against children, which resulted in their death several times. The activity of on-call specialists is focused on making quick decisions in response to reports of violations of children’s rights in the family and society.
Qualitative research revealed the experience of on-call specialists in relation to the assessments of violations of children’s rights in daily activities and the reactions of parents/ guardians to the assistance provided by on-call specialists.
Training of general working physical skills of young adults with intellectual disabilities through an integrated physical capacity program
Authors: Dobrovolskytė Ilona 
Published: December 2020

The article describes a quasi-experiment that lasted 3 months and an integrated physical capacity training (IPCT) program, a diagnostic assessment of general working physical abilities using the Ergos IITM Work Simulator system. The results of the study reveal the impact of the IPCT program on the change of general work physical abilities and the assessment of subjective efforts of young adults with intellectual disabilities.