bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal Fractures: The Role of Primary Reduction and Secondary Revision
Authors: Wang Weitao , Lee Thomas , Kohlert Scott , Kadakia Sameep , Ducic Yadranko 
Published: November 2019

AbstractThe nasal bones are among the most commonly fractured bones in the facial skeleton. Proper management of nasal trauma acutely is important in minimizing secondary deformities and impaired function with nasal airway obstruction. Septal hematoma, if present, should be drained right away. Acutely closed nasal reduction and limited septoplasty can be performed. Unrecognized septal fracture may play a role in the failure of closed nasal reduction of fractured nasal bones. Complex nasoorbitoethmoid fractures are approached openly and treated with rigid fixation. Primary use of open rhinoplasty in an acute setting is debated, and there are no clearly accepted indications for timing, patient selection, and surgical technique. However, open septorhinoplasty is more commonly used in a delayed fashion to provide definitive correction of any residual cosmetic or functional problems. Recent algorithms provide a systematic approach to nasal trauma and may improve secondary deformity rates following closed reduction.
Management of Orbital Floor Fractures
Authors: Shokri Tom , Alford Mark , Hammons Matthew , Ducic Yadranko , Sokoya Mofiyinfolu 
Published: November 2019

AbstractFractures of the orbital floor represent a common yet difficult to manage sequelae of craniomaxillofacial trauma. Repair of these injuries should be carried out with the goal of restoring normal orbital volume, facial contour, and ocular motility. Precise surgical repair is imperative to reduce the risk of long-term debilitating morbidity. This article aims to review concepts on the management of orbital floor fractures in the hope of further elucidating perioperative evaluation and decision-making regarding operative intervention.
Role of Free Tissue Transfer in Facial Trauma
Authors: Kim Roderick Y. , Sokoya Momofiyin , Williams Fayette C. , Shokri Tom , Ducic Yadranko 
Published: November 2019

AbstractFor large composite traumatic defects of the head and neck, free tissue transfer presents a reconstructive allowing for the reconstitution of both form and function. Furthermore, the ability to provide bulk, soft, and hard tissue, as well as immediate dental rehabilitation, makes free tissue transfer an efficient and attractive option for head and neck reconstruction. Herein, we discuss the utility of free tissue transfer in facial trauma, its problems, complications, and controversies.
Management of Skull Fractures and Calvarial Defects
Authors: Vincent Aurora , Sokoya Mofiyinfolu , Shokri Tom , Gordin Eli , Inman Jared C. , Manolidis Spiros , Ducic Yadranko 
Published: November 2019

AbstractScalp and calvarial defects can result from a myriad of causes including but not limited to trauma, infection, congenital malformations, neoplasm, and surgical management of tumors or other pathologies. While some small, nondisplaced fractures with minimal overlying skin injury can be managed conservatively, more extensive wounds will need surgical repair and closure. There are many autologous and alloplastic materials to aid in dural and calvarial reconstruction, but no ideal reconstructive method has yet emerged. Different reconstructive materials and methods are associated with different advantages, disadvantages, and complications that reconstructive surgeons should be aware of. Herein, we discuss different methods and materials for the surgical reconstruction of calvarial defects.
Reliability and Feasibility of the Self-Administered ISTH-Bleeding Assessment Tool
Authors: Punt Marieke C. , Blaauwgeers Maaike W. , Timmer Merel A. , Welsing Paco M.J. , Schutgens Roger E.G. , van Galen Karin P.M. 
Published: November 2019

Abstract
Introduction Standardized bleeding assessment tools (BATs), such as the International Society for Thrombosis and Hemostasis (ISTH)-BAT, are screening instruments used during the diagnostic workup of suspected bleeding disorders. A self-administered ISTH-BAT (self-BAT) would enhance screening and save time during an outpatient clinic visit.
Aim This study was aimed to investigate the reliability and feasibility of the self-BAT.
Methods The electronic self-BAT was created from the ISTH-BAT and paper-version of self-BAT and optimized by patients and physicians. Patients with a (suspected) congenital platelet defect (CPD), who had previously undergone physician-administered ISTH-BAT assessment, were invited to complete the self-BAT. Optimal self-BAT cut-off values to detect a bleeding tendency, as defined by the ISTH-BAT, were evaluated by receiver operator characteristic (ROC) curve analysis to reach a sensitivity ≥95%. Reliability was tested by assessing sensitivity, specificity, and intraclass correlation (ICC). Feasibility was evaluated on comprehension and length of self-BAT.
Results Both versions of the BAT were completed by 156 patients. Optimal cut-off values for self-BAT to define a bleeding tendency were found to be identical to those of the ISTH-BAT. Normal/abnormal scores of the ISTH-BAT and self-BAT were agreed in 88.5% (138/156, 95% confidence interval [CI]: 0.83–0.93) of patients. The sensitivity and specificity of the self-BAT to detect a bleeding tendency were 96.9 and 48.1%, respectively. The ICC was 0.73. Self-BAT questions were graded by 96.8% (151/156) as “very easy,” “easy,” and “satisfactory” and questionnaire length as “exactly right” by 91% (142/156) of patients.
Conclusion In patients with a (suspected) CPD, the self-BAT is sufficiently reliable and feasible to detect a bleeding tendency, which supports its use as a screening tool.
Micronized Dehydrated Human Amnion Chorion Membrane Injection in the Treatment of Knee Osteoarthritis—A Large Retrospective Case Series
Authors: Alden Kris J. , Harris Stan , Hubbs Brandon , Kot Kimberly , Istwan Niki B. , Mason David 
Published: November 2019

AbstractOsteoarthritis (OA) of the knee is a leading cause of chronic pain and disability in the United States. Current treatment options primarily target OA symptoms reserving surgical intervention and knee replacement for those who fail conservative measures. With average age of patients with knee OA decreasing, regenerative treatment approaches to reduce symptoms, increase quality of life, and delay the need for surgical intervention are increasingly sought. Human amniotic membrane contains growth factors and cytokines, which promote epithelial cell migration and proliferation, stimulate metabolic processes leading to collagen synthesis, and attract fibroblasts, while also reducing pain and inflammation. Micronization of the tissue allows for suspension in normal saline and injection. We conducted a retrospective review of 100 knees treated for symptomatic OA with micronized dehydrated human amnion/chorion membrane (mdHACM) and followed for 6 months. Our purpose is to present our experience and patient outcomes. Data were abstracted from electronic medical records of 82 consecutive OA patients (100 knees) injected with 100 mg mdHACM. Patient age, gender, adverse events and routinely collected Knee Injury and Osteoarthritis Outcome Score (KOOS) were evaluated. Effectiveness of mdHACM treatment was measured by serial KOOS at baseline, and posttreatment at 6 weeks, 3, and 6 months. Overall mean KOOS for the cohort was 40 at baseline, improving to 52, 62, and 65 at 6 weeks, 3 months, and 6 months post-mdHACM injection. Percent increases were 32, 56, and 65%, respectively. Quality of life and sports/recreation domains improved by 111 and 118%, respectively, at 6 months. Pain scores improved by 67% at 6 months. All scores improved throughout the observation period. The most common adverse event was pain after injection lasting 2 to 7 days, observed in 68% of cases. This represents the largest single-physician experience with mdHACM for treatment of knee OA reported to date. Injectable mdHACM appears to be a potentially useful treatment option for knee OA patients. Controlled studies are underway to confirm these observations.
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy
Authors: Van Eyck Lien , Bruni Francesco , Ronan Anne , Briggs Tracy A. , Roscioli Tony , Rice Gillian I. , Vassallo Grace , Rodero Mathieu P. , He Langping , Taylor Robert W. , Livingston John H. , Chrzanowska-Lightowlers Zofia M. A. , Crow Yanick J. 
Published: November 2019

Abstract
Background A homozygous founder mutation in MTPAP/TENT6, encoding mitochondrial poly(A) polymerase (MTPAP), was first reported in six individuals of Old Order Amish descent demonstrating an early-onset, progressive spastic ataxia with optic atrophy and learning difficulties. MTPAP contributes to the regulation of mitochondrial gene expression through the polyadenylation of mitochondrially encoded mRNAs. Mitochondrial mRNAs with severely truncated poly(A) tails were observed in affected individuals, and mitochondrial protein expression was altered.
Objective To determine the genetic basis of a perinatal encephalopathy associated with stereotyped neuroimaging and infantile death in three patients from two unrelated families.
Methods Whole-exome sequencing was performed in two unrelated patients and the unaffected parents of one of these individuals. Variants and familial segregation were confirmed by Sanger sequencing. Polyadenylation of mitochondrial transcripts and de novo synthesis of mitochondrial proteins were assessed in patient's fibroblasts.
Results Compound heterozygous p.Ile428Thr and p.Arg523Trp substitutions in MTPAP were recorded in two affected siblings from one family, and a homozygous p.Ile385Phe missense variant identified in a further affected child from a second sibship. Mitochondrial poly(A) tail analysis demonstrated shorter posttranscriptional additions to the mitochondrial transcripts, as well as an altered expression of mitochondrial proteins in the fibroblasts of the two siblings compared with healthy controls.
Conclusion Mutations in MTPAP likely cause an autosomal recessive perinatal encephalopathy with lethality in the first year of life.
2.2 Metal/Biocatalyst Dual Catalysis
Authors: Diéguez M. , Bäckvall J.-E. , Pàmies O. 
Published: November 2019

AbstractChemoenzymatic dynamic kinetic resolution (DKR) and dynamic kinetic asymmetric transformation (DYKAT) processes have become some of the most appealing transformations for the preparation of chiral molecules. In this review, we present the huge advances made in the combination of a metal racemization catalyst and a biocatalyst for the synthesis of enantiopure alcohols, amines, and other relevant compounds.
A Fabry – Perot interferometer formed in the core of a composite optical fibre heavily doped with phosphorus oxide
Authors: Egorova O.N. , Vasil’ev S.A. , Likhachev I.G. , Sverchkov S.E. , Galagan B.I. , Denker B.I. , Semjonov S.L. , Pustovoi V.I. 
Published: November 2019

Abstract
We report a new method for manufacturing a Fabry – Perot interferometer in the form of a microcavity in the optical fibre core. The method is based on the use of the process of electric discharge fusion splicing of a conventional optical fibre and a special composite fibre having a core with a high content of phosphorus oxide. The possibility of using this interferometer as a sensitive element of a strain sensor with high temperature stability is shown.
Silica fibres activated by YAG : Nd3+ nanocrystals
Authors: Evstropiev S.K. , Aseev V.A. , Demidov V.V. , Kuz’menko N.K. , Matrosova A.S. , Khokhlov A.V. , Komarov A.V. , Dukelskii K.V. , Nikonorov N.V. , Oreshkina K.V. 
Published: November 2019

Abstract
We report data on the development of a polymer – salt method for the formation of aluminium yttrium garnet crystals doped with neodymium ions (YAG : Nd) inside the channels of a preform of microstructured fibre based on pure silica glass. The crystals are obtained by impregnating the channels with aqueous solutions of thermally decomposable salts (yttrium nitrate, aluminium nitrate, neodymium chloride) and an organic polymer, followed by drying and heat treatment at a temperature of 1100 °C. The resulting composite structure is drawn into the fibre at a temperature of 2000 °C. Using X-ray diffraction analysis, the presence of oriented YAG : Nd crystals ranging in size from 25 to 37 nm in the silica glass matrix of fibre is established. Measurements of the spectral dependence of optical losses in fibre show the presence of absorption bands of the optical signal, characteristic of Nd3+ ions. The shape of the luminescence spectra of nanocrystals is typical of YAG : Nd with a radiation peak at a wavelength of 1064 nm.
Coherent optical frequency-domain reflectometer based on a fibre laser with frequency self-scanning
Authors: Tkachenko A.Yu. , Lobach I.A. , Kablukov S.I. 
Published: November 2019

Abstract
The first results of an experimental study of a coherent optical frequency-domain reflectometer (C-OFDR) based on a simple single-frequency fibre laser with frequency self-scanning are presented. The self-scanning laser generates microsecond pulses, and its lasing frequency changes linearly with a change in the pulse number without using any actively tuned elements. In addition, the generation of each pulse occurs on only one longitudinal mode with a linewidth less than 1 MHz. This laser is characterised by a high linearity of frequency tuning, due to which reflectograms can be measured without any additional spectral correction. The C-OFDR demonstrates a possibility of attaining a spatial sampling of ∼200 μm and a reflectance sensitivity of approximately down to – 80 dB at a test line length of ∼9 m.
Aromatic and heteroaromatic azacrown compounds: advantages and disadvantages of rigid macrocyclic ligands
Authors: Zubenko Anastasia D. , Fedorova Olga A. 
Published: November 2019

Current approaches to the synthesis of aromatic and heteroaromatic azamacrocycles and their derivatives are summarized and systematized. The relationship between the structure of azacrown compounds and their complexation behaviour towards metal cations is analyzed. The diversity of practical applications of azamacrocyclic derivatives in medicine, biology and analytical and organic chemistry, as well as for the design of molecular devices is demonstrated.
The bibliography includes 307 references.
Recent advances in the chemistry of pyridazine — an important representative of six-membered nitrogen heterocycles
Authors: Sergeev Pavel G. , Nenajdenko Valentin G. 
Published: November 2019

The review is devoted to recent advances in the chemistry of pyridazine — a six-membered heterocycle containing two nitrogen atoms in adjacent positions. The practical significance of title compounds is demonstrated and published data of the last decade devoted to them are considered systematically. The modern synthetic approaches to pyridazine derivatives are described in detail, analyzed and classified according to the precursor molecules involved in ring closure. The chemical properties of pyridazines are considered, including both reactions of the diazine ring and reactions of various substituents attached to the ring. Particular attention is given to the application of some pyridazine derivatives as pharmaceuticals, optical materials and ligands for catalysis.
The bibliography includes 180 references.
Correlated photon-pair generation in a liquid-filled microcavity
Authors: Rönchen Felix , Langerfeld Thorsten F , Köhl Michael 
Published: November 2019

Abstract
We report on the realization of a liquid-filled optical microcavity and demonstrate photon-pair generation by spontaneous four-wave mixing. Our source has a spectral brightness of 45 ± 7 mW−2 s−1 MHz−1 and the bandwidth of the emitted photons is ∼300 MHz. We demonstrate tuning of the emission wavelength between 770 and 800 nm. Moreover, by employing a liquid as the nonlinear optical medium completely filling the microcavity, we observe more than a factor 103 increase of the pair correlation rate per unit pump power and a factor of 1.7 improvement in the coincidence/accidental ratio as compared to our previous measurements.
Value at risk in the black litterman portfolio with stock selection through cluster analysis
Authors: Subekti R , Ratna Sari E , Kusumawati R , Pintari H O , Renggani P 
Published: November 2019

Abstract
The aim of this paper is to support the new strategy in the previous research where Black Litterman procedure is assisted by clustering for the process of given views. We provide the empirical result and focus on how to compute the Value at Risk (VaR) to illustrate the risk measure on Black Litterman as a reference portfolio.
Misconceptions of Derivative and Integration Techniques among Engineering Students: A Case Study
Authors: Zehra A , Abbasi S J 
Published: November 2019

Abstract
This study examines and identifies the problems faced by engineering students in Pakistani universities to learn derivatives and integrations techniques in their first semester calculus course. The study based on data collected from 250 engineering students. In the process of data analyzing students’ misconceptions lie as follows:1) Product and quotient rules of derivatives were applied on integration problems. 2) ln Function was integrated by using derivative techniques. 3) Integrations of trigonometric functions were evaluated by using derivative techniques. 4) Students were found confused in the derivatives and integration using substation techniques. The results of this study will identify the students’ problems and will help them getting clear insight to improving their technology aided learning skills.
Analysis of Factors Affecting the Health Insurance Ownership with Binary Logistic Regression Model
Authors: Astari D W , Kismiantini  
Published: November 2019

Abstract
Having health insurance is an important decision for enjoying the security of a safe future. Health insurance can protect people from a large amount of medical costs. More Indonesian have health insurance now a days than ever before since the government is committed to supporting the universal health care. This study aims to determine factors affecting the health insurance ownership and to understand their relations in Indonesia using a binary logistic regression model. The data used in this study came from the fifth wave of the Indonesian Family Life Survey (IFLS). There were 29,508 respondents where 14,653 among them have health insurance. The logistic regression model suggested that job, education, chronic condition, marital status, and inpatient care were statistically significant to the health insurance ownership (yes/no), while not significant for gender and health condition. Fitting the logistic regression model with age as the only explanatory variable yielded that the probability of having health insurance increased in line with age.
Implementing ordinal regression model for analyzing happiness level in Indonesia
Authors: Pratiwi N M , Kismiantini  
Published: November 2019

Abstract
Happiness can be an indicator of social progress achievement in developing a country. Understanding factors affecting the level of happiness in a country become important in the study of subjective well-being. This study aims to determine factors that influence happiness in Indonesia using the fifth wave of Indonesian Family Life Survey (IFLS) data. From the national data of 29,336 participants in 13 provinces were reported that 13.4% of the participants responded they were very happy, 78.6% were happy, 7% were unhappy, and 1% were very unhappy. Ordinal regression models in particular proportional odds models were implemented on analyzing factors of the four levels of happiness. The significant variables associated with happiness were age, marital status, job status, education, satisfaction, economic level, health, and religious variables. Sex, hopeful, personality, and social relation were not significantly associated with people’s happiness. Happy people have higher probabilities of happiness than others. Very happy appeared to have lower probabilities of happiness as their ages increasing, while in contrast to unhappy and very unhappy people.
Coffee prices behavior in the Indonesian market and its implication to derivatives pricing
Authors: Binatari N , Latip A 
Published: November 2019

Abstract
Indonesia is one of the main producers of agricultural commodities including coffee. Whereas the physical market of coffee in Indonesia, as a commodity, has been existed for centuries, the derivative market of coffee has just begun to appear recently as the result of demand growth for local market and export purpose. The paper market emerges as the outcome of the need of the producers, suppliers, and buyers to hedge against the risk of the availability and the prices volatility of coffee. In this growing commodity derivative market, it is important to examine the regular pattern and behavior of the coffee price for pricing purpose of its derivatives, especially in the specific case for the Indonesian market. This paper analyses the spot, futures, and option of coffee in Indonesia. The coffee spot price process is presented along with the parameters and its implication to derivatives pricing.
VND in CVRP, MDVRP, and VRPTW cases
Authors: Satyananda D , Wahyuningsih S 
Published: November 2019

Abstract
Vehicle Routing Problem (VRP) has an important role in logistics distribution from the depot to the customer, to get the minimum cost delivery route. To get optimal results, it is necessary to improve route from the initial solution. Variable Neighbourhood Descent (VND) is one of the metaheuristics that examine of a number of neighbourhood operators to get the optimal route. A VRP route is called optimal if there are no other routes that can be generated from all the neighbourhood operators used in VND. This article describes the application of VND to get the optimal route on CVRP, MDVRP, and VRPTW. The results of the experiment on some test data used indicate that VND can be used to get more optimal length and travel time route.
Modify Variational Iteration Method for Solving Heat Equations
Authors: Saptaningtyas F Y , Ahmadi  
Published: November 2019

Abstract
The Variational Iteration method (VIM) is one of the semi approximation procedure to solve numerous differential problems. Many literatures shows that this method need to be rectify to get preferable results. This research would like to modify VIM on the replacement the initial value in each steps. Although this method enact the algorithm more complex, but modify VIM gives good outcomes peculiarly in long time intervals. We compare the solutions with the analytical solution using separation variable. The results denotes that both of the VIM and modify VIM have small error in solving heat equation in Dirichlet boundary. It could be seen that the modify VIM give better solutions instead of VIM.
Computer Assisted Learning on Aridity Disaster Learning Using SIMIA (Satellite Imagery for Modelling Index of Aridity)
Authors: Paseleng M C , Prasetyo S Y J , Hartomo K D 
Published: November 2019

Abstract
The purpose of this study is to develop Computer Assisted Learning (CAL) to identify aridity using Satellite Imagery Modelling Index of Aridity (SIMIA) media. SIMIA is a system used to model area of aridity by using of rainfall data from observation of rain and vegetation index extracted by satellite image of LANDSAT 8 OLI and Google Satellite. SIMIA learning planning is performed using procedures of Analyzed, Standardized, Strategy, Utility, Require, and Evaluate (ASSURE). The results show that the ASSURE learning plan is more systematic, it attracts the attention of the participants; it can illustrate the goal to be achieved as determined by the learning achievements. The SIMIA CAL learning plan using ASSURE allows for the selection and delivery of appropriate, timely (pedagogical) content, the use of technology is appropriate to the needs of learners (technology) and the interaction is created between learners and instructors.