bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory outcomes of “new” bronchopulmonary dysplasia in adolescents: A multicenter study
Authors: Pérez‐Tarazona Santiago , Rueda Esteban Santiago , García‐García Maria L. , Arroyas Sanchez Maria , de Mir Messa Inés , Acevedo Valarezo Tatiana , Mesa Medina Orlando , Callejón Callejón Alicia , Canino Calderín Elisa M. , Albi Rodriguez Salome , Ayats Vidal Roser , Salcedo Posadas Antonio , Costa Colomer Jordi , Domingo Miró Xavier , Berrocal Castañeda Montserrat , Villares Porto‐Dominguez Ana ,   the Working Group of Perinatal Respiratory Diseases of the Spanish Society of Pediatric Pulmonology
Published: December 2020

AbstractObjectiveLong‐term respiratory consequences of bronchopulmonary dysplasia (BPD) in preterm infants born in the post‐surfactant era (“new” BPD) remain partially unknown. The present study aimed to evaluate the respiratory outcomes of “new” BPD in adolescents who were born preterm.MethodsThis multicenter, cross‐sectional study included 286 adolescents born between 2003 and 2005 (mean age: 14.2 years); among them, 184 and 102 were born extremely preterm (EP; <28 weeks' gestation) and moderate–late preterm (32 to <37 weeks' gestation), respectively. Among EP adolescents, 92 had BPD, and 92 did not. All participants underwent lung function tests, skin prick testing, and questionnaires on asthma symptoms and quality of life.ResultsEP adolescents with BPD had significantly lower forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow between 25% and 75% of FVC than other included adolescents. FEV1/FVC ratios were below the lower limit of normal (z‐score <−1.645) in 30.4% of EP adolescents with BPD, 13.0% of EP adolescents without BPD, and 11.8% of adolescents who were born moderate–late preterm. Bronchodilator response and air‐trapping were significantly higher in BPD adolescents than in other adolescents. Diffusion capacity was significantly lower in EP adolescents than in moderate–late preterm adolescents. Asthma symptoms and quality‐of‐life scores were similar among groups.ConclusionEP adolescents with “new” BPD had poorer pulmonary function than EP adolescents without BPD or moderate–late preterm adolescents. Further studies are needed to determine whether “new” BPD is associated with early‐onset chronic obstructive pulmonary disease in adulthood.
Quantum Semantic Learning by Reverse Annealing of an Adiabatic Quantum Computer
Authors: Rocutto Lorenzo , Destri Claudio , Prati Enrico 
Published: December 2020

AbstractRestricted Boltzmann machines (RBMs) constitute a class of neural networks for unsupervised learning with applications ranging from pattern classification to quantum state reconstruction. Despite the potential representative power, the diffusion of RBMs is quite limited since their training process proves to be hard. The advent of commercial adiabatic quantum computers (AQCs) raised the expectation that the implementations of RBMs on such quantum devices can increase the training speed with respect to conventional hardware. Here, the feasibility of a complete RBM on AQCs is demonstrated, thanks to an embedding that associates the nodes of the neural networks to virtual qubits. A semantic quantum search is implemented thanks to a reverse annealing schedule. Such an approach exploits more information from the training data, mimicking the behavior of the classical Gibbs sampling algorithm. The semantic training is shown to quickly raise the sampling probability of a subset of the set of the configurations. Even without a proper optimization of the annealing schedule, the RBM semantically trained achieves good scores on reconstruction tasks. The development of such techniques paves the way toward the establishment of a quantum advantage of adiabatic quantum computers, especially given the foreseen improvement of such hardware.
Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease
Authors: Kaenmuang Punchalee , Navasakulpong Asma 
Published: December 2020

AbstractClinically amyopathic dermatomyositis (CADM) with anti‐melanoma differentiation‐associated gene 5 antibody is associated with rapidly progressive interstitial lung disease (RP‐ILD) which results in up to 50% mortality, especially within six months of diagnosis. However, limited data are available on this disease. This is the first case series of six patients in Thailand diagnosed with CADM with ILD. All patients presented with respiratory symptoms, such as progressive dyspnoea, dyspnoea on exertion, or cough. High‐resolution computed tomography of the chest showed predominantly subpleural and peripheral consolidation in both lower lungs. Four patients had RP‐ILD and three of the RP‐ILD patients died within seven weeks of diagnosis. These cases illustrate the clinical characteristics, chest imaging, treatments, and clinical outcomes of the patients diagnosed with CADM and ILD.
Hydro‐physical soil properties as influenced by short and long‐term integrated crop–livestock agroecosystems
Authors: Dhaliwal Jashanjeet K. , Kumar Sandeep 
Published: December 2020

AbstractIntegration of cover crops and livestock (ICLS) in an existing corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] cropping system can be an effective strategy to improve soil physical and hydrological properties. Three on‐farm long‐term (≥30 yr) sites (Sites 1, 2 and 3) and one short‐term (3 yr) experimental site (Site 4) with a randomized block design in eastern South Dakota were selected to evaluate the impacts of ICLS on soil physical and hydrological properties. At Sites 1, 2, and 3, the following long‐term management systems were compared: ICLS (corn/grazing–soybean/grazing–cover crop/grazing), control (CNT, corn–soybean with no cover crop and no grazing), and a grazed pasture (GP). At Site 4, the treatments included ICLS (corn/grazing–soybean/grazing–oat [Avena sativa L.]–cover crop/grazing], cover crop (corn–soybean–oat–cover crop with no grazing), CNT (corn–soybean–oat without cover crop and grazing), and GP. Data showed that soil organic carbon (SOC) was higher by 20–26% and bulk density was lower by 18–37% in long‐term ICLS compared with CNT. Long‐term ICLS also improved soil water retention, macroporosity, infiltration rate, and total porosity compared with the CNT. However, these properties were not affected by short‐term ICLS at Site 4. The GP had the lower soil bulk density and higher SOC and infiltration rate compared with ICLS and the CNT except at Site 4. This study showed that long‐term integration of cover crops and livestock grazing under ICLS can be beneficial in enhancing soil physical and hydrological properties. However, whether such integration improves other soil quality parameters and crop yield requires further investigation.
Ru‐Catalyzed Cross Dehydrogenative Coupling Leading to Si−O and Si−S Bond Formations and Also Stimulating an Alternative Scope for Hydrogenation of C=O, C=N and N=N Bonds
Authors: Ghosh Avik , Debnath Tanay , Ash Tamalika , Banerjee Soumadip , Das Abhijit K. 
Published: December 2020

AbstractReaction pathways involved in catalytic Cross Dehydrogenative Coupling (CDC) reactions leading to formation of Si−O and Si−S bonds have been formulated and explored theoretically using Density Functional Theory (DFT). The advantage of the weak Si−H bond has been exploited to carry out coupling with water, alcohol and thiol, along with H2 release. Ru complex, [K(dme)2][Ru(H)(trop2dad)] when reacts with water generates a neutral complex, [Ru(trop2dad)]. This neutral complex has been employed to act as a catalyst in CDC reactions. It has also been found that the complex, [Ru(H2)(trop2dad)] formed within the catalytic cycle may also be used for hydrogenation of C=O, C=N and N=N bonds. The optimized geometries of all the complexes and transition states have been obtained using wB97xd functional in conjunction with 6‐31++G(d,p) basis set. The whole assisting phenomena in solvent medium has been investigated through the implementation of conductor‐like screening solvation model (COSMO) considering tetrahydrofuran as the bulk solvent medium. The Turnover frequency (TOF) has been calculated by Energetic Span Model. The theoretical investigation extends the role of the ruthenium catalyst to the regime of ‘element to element’ bond formation, along with H2 release, which may be significant in the field of energy storage, and also triggers an alternative possibility of hydrogenation of carbonyls, imines and diazo compounds.
Graphene‐Driven Metadevice for Active Microwave Camouflage with High‐Efficiency Transmission Window
Authors: Huang Cheng , Yang Jianing , Ji Chen , Yuan Liming , Luo Xiangang 
Published: December 2020

AbstractThe general method to achieve electromagnetic (EM) invisibility is to use absorbing materials that can reduce the backscattering microwave signals. However, they will influence the transmission of useful signals, and their passive operation mode also blocks the realization of active camouflage systems. Here, the authors propose an electrically tunable metadevice which can dynamically manipulate the reflection magnitude and realize high‐efficiency transmission at two distinctive frequency bands. Such a metadevice is driven by graphene sandwich structure integrated with multi‐layer metasurface. By electrically controlling the sheet resistance of graphene, the authors have experimentally verified that the metadevice can tune the reflection magnitude from −5 to −20 dB over a wide frequency band of 5–15 GHz, and meanwhile realize a high transparent EM window with 3‐dB transmission band covering from 23 to 25 GHz. The operation mechanism is discussed by examining the electric field distribution and also employing an equivalent circuit model to analyze the input impedance. Furthermore, using the developed metadevice, the authors still demonstrate its dynamical camouflaging performance and application potential as an antenna radome by experiment. The finding in this study is expected to trigger great interest in adaptive camouflage, stealth radome, and multifunctional EM manipulation fields.
Tetralogy of Fallot—A literature review
Authors: Muirhead Sarah‐Joy 
Published: December 2020

AbstractTetralogy of Fallot is a combination of four specific cardiac abnormalities. (a) A ventricular septal defect (VSD), (b) pulmonary valve stenosis/right ventricular outflow tract obstruction, (c) aorta overriding the VSD, and (d) right ventricular hypertrophy. This review attempts to outline the current literature regarding embryology, morphology, pathophysiology, ultrasound appearances and the current treatments/outcomes of infants with Tetralogy of Fallot. Tetralogy of Fallot is the most commonly occurring conotruncal anomaly. Here, the aim is to present the ultrasound features, with examples of Tetralogy of Fallot along with the story post birth in terms of surgical treatment. This information was gathered doing a literature search using PubMed and the University of South Australia library database, as well as through information provided by the Royal Children's Hospital Cardiology department, via fact sheets. With early diagnosis under ultrasound, preparations can be made and counseling provided to organize for intervention and further assessment after birth. With current surgical intervention, the survival rate past the age of 10 is now over 92%, when, 50 years ago, it was only 50%.
Small carbonaceous fossils (SCFs) from North Greenland: new light on metazoan diversity in early Cambrian shelf environments
Authors: Wallet Elise , Slater Ben J. , Willman Sebastian , Peel John S. 
Published: December 2020

AbstractThe Sirius Passet Lagerstätte of North Greenland is one of the oldest records of soft‐bodied metazoan‐dominated ecosystems from the early Cambrian. The Lagerstätte site itself is restricted to just a singlec. 1‐km‐long outcrop located offshore from the shelf margin, in an area affected by metamorphic alteration during the Ellesmerian Orogeny (Devonian – Early Carboniferous). The recent recovery of small carbonaceous fossils (SCFs) to the south, in areas that escaped the effects of this deformation, has substantially expanded the known coverage of organic preservation into shallower water depositional settings in this region. Here, we describe additionalSCFassemblages from the siliciclastic shelf succession of the Buen Formation (Cambrian Series 2, stages 3–4;c. 515 Ma), expanding the previously documentedSCFbiota. Newly recovered material indicates a rich diversity of non‐mineralizing metazoans, chiefly represented by arthropod remains. These include the filtering and grinding elements of a sophisticated crustacean feeding apparatus (the oldest crustacean remains reported to date), alongside an assortment of bradoriid sclerites, including almost complete, 3D valves, which tie together a number ofSCFs previously found in isolation. Other metazoan remains include various trilobite cuticles, diverse scalidophoran sclerites, and a range of metazoan fragments of uncertain affinity. This shallower water assemblage differs substantially from the Sirius Passet biota, which is dominated by problematic euarthropod stem‐group members and sponges. Although some of these discrepancies are attributable to taphonomic or temporal factors, these lateral variations in taxonomic composition also point to significant palaeoenvironmental and/or palaeoecological controls on early Cambrian metazoan communities.
Aromaticity of nucleic acid bases
Authors: Szatylowicz Halina , Stasyuk Olga A. , Solà Miquel , Krygowski Tadeusz M. 
Published: December 2020

Abstract3D shape and the resulting physicochemical properties of double‐helical DNA/RNA structures are determined not only by individual nucleobases, but also by their additive intermolecular interactions. Energetic contribution from aromatic π–π stacking to the stabilization of DNA/RNA is not small and sometimes even comparable to that from H‐bonding. The basis of the stacking interactions lies in the π‐electron structure of individual nucleobases, which can be described by various aromaticity indices. Heteroatoms and exocyclic functional groups make the electronic structure of nucleobases different from aromatic hydrocarbons. Consequently, the cyclic π‐electron delocalization is not the only factor responsible for the relative stability of their tautomers. This review puts the spotlight on interplay between aromaticity of purine and pyrimidine nucleobases and their tautomeric preferences, as well as on the effects of different noncovalent interactions (hydrogen bonding, metal ion coordination, and π–π stacking) on π‐electron delocalization of five‐ and six‐membered rings in individual nucleobases and their complexes.This article is categorized under:
Structure and Mechanism > Molecular Structures
Electronic Structure Theory > Density Functional Theory
Nanotechnology‐based approaches for treating lysosomal storage disorders, a focus on Fabry disease
Authors: Abasolo Ibane , Seras‐Franzoso Joaquin , Moltó‐Abad Marc , Díaz‐Riascos Vanessa , Corchero José Luis , Pintos‐Morell Guillem , Schwartz Simó 
Published: December 2020

AbstractLysosomal storage disorders (LSDs) are a group of rare diseases in which the defect of a lysosomal protein results in a pathogenic accumulation of nonmetabolized products within the cells. The main treatment for LSDs is enzyme replacement therapy (ERT), consisting in the exogenous administration a recombinant protein to replace the defective one. Although several diseases such as Gaucher, Fabry, and Pompe are treated following this approach, ERT is limited to LSDs without severe neuronal affectation because recombinant enzymes do not cross the blood–brain barrier. Moreover, ERT shows additional drawbacks, including enzyme low half‐life, poor bioavailability, and immunogenic responses. In this scenario, nanotechnology‐based drug delivery systems (DDS) have been proposed as solution to overcome these limitations and improve the efficacy of ERT. The present review summarizes distinct approaches followed by our group and collaborators on the use of DDS for restoring lysosomal enzymes in disease‐affected cells. During the last decade, we have been exploring different synthetic nanoparticles, from electrolytic complexes, to liposomes and aggresomes, for the delivery of α‐galactosidase A (GLA) enzyme. Studies were mainly conducted on Fabry disease models, but results can be also extrapolated to other LSDs, as well as to other diseases treated with alternative therapeutic proteins. The advantages and disadvantages of different DDS, the difficulties from working with very labile and highly glycosylated enzymes and the relevance of using appropriate targeting moieties is thoroughly discussed. Finally, the use of natural DDS, namely extracellular vesicles (EVs) is also introduced.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease
Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Gendered Tradeoffs
Authors: Hook Jennifer L. , Li Meiying 
Published: December 2020

AbstractIn this chapter we review the research linking national-level family policies on childcare services and parental leave to women’s labor market outcomes. We review the state of the literature in answering two primary questions: (1) Do generous family policies perpetuate gender inequality in the labor market? That is, do family policies have unintended consequences or promote women’s inclusion into the labor force at the expense of gender equality within it? (2) Do generous family policies promote gender equality for certain groups of women at the expense of other groups of women? In answering this second question we focus on how policies differentially affect women by social class. We conclude with directions for future research.
How Well Do European Child-Related Leave Policies Support the Caring Role of Fathers?
Authors: Bartova Alzbeta , Keizer Renske 
Published: December 2020

AbstractOur chapter analyses the extent to which European countries (1) recognize the caring responsibilities of fathers toward their children and (2) value fathers’ caring role. To do so, we analyze the designs of individual leave policies and reflect on them by assessing available data on leave uptake by fathers in 13 European countries. Our results show that there is great variation in child-related leave designs across Europe. Our findings, in line with previous work, underscore the importance of generous individual non-transferable leave entitlements. Moreover, our findings bring forward aspects of leave designs that are rarely discussed when considering fathers’ leave uptake. Our results indicate that generous non-transferable leave rights should be paired with (a) clearly defined leave periods for fathers, (b) individual entitlement to benefits, and (c) greater scope for flexibility to increase the attractiveness of child-related leave and to strengthen fathers’ position when negotiating their childcare leave.
Private Childcare and Employment Options: The Geography of the Return to Work for Mothers in the Netherlands
Authors: Emery Tom 
Published: December 2020

AbstractThe Netherlands provides extensive and flexible support for young parents and met the Barcelona targets for childcare provision even before they were set. Yet childcare isn’t evenly distributed, and provision is better for some than for others. We use the NKPS to examine childcare availability and its association with maternal employment. To enrich this analysis, respondents are geocoded and this enables them to be linked to the Landelijk Register Kinderopvang en Peuterspeelzalen (Register for Childcare and Toddler Groups; www.landelijkregisterkinderopvang.nl). In linking this data, three often neglected dimensions of childcare provision are captured. First, at the most basic level the geographic proximity of childcare services is captured (i.e. distance to nearest provider). Second, the intensity or availability of choice is measured (i.e. number of providers within 2 kms). Third, the diversity of options is measured (i.e. the ratio of different types of providers).
The Educational Gradient in Company-Level Family Policies
Authors: Begall Katia , van der Lippe Tanja 
Published: December 2020

AbstractIn this chapter, the educational gradient in access to different organizational work-family policies is examined using unique multilevel survey data from the European Sustainable Workforce Survey covering nine European countries. A total of six different work-family policies are studied, representing working-time arrangements, leaves, and services. By combining information provided by the organization, the direct supervisor, and the employee we show that for all policies, access reported by employees is substantially lower than provision reported by the team managers, which in turn is lower than the provision reported by the HR managers. This points to complex processes in the distribution of information in organizations. Moreover, at the organizational as well as the employee level, higher skilled employees have more access to working-time arrangements. We conclude that the skill gaps in the access to organizational work-family policies identified in this chapter form an important dimension of social inequality in today’s labor market.
Do International Organizations Influence Domestic Policy Outcomes in OECD Countries?
Authors: White Linda A. 
Published: December 2020

AbstractThis chapter examines to what extent policy ideas and norms promoted at the transnational and international level around gender and family policy are influential at the domestic policy level in OECD countries. Existing research demonstrates a mixed record in terms of transnational and international non-state actors’ influence on domestic policy in the Global North. This chapter argues that international norms are diffusing to domestic policy actors and processes rather unevenly. While international organizations (IOs) and transnational advocates can facilitate the spread of ideas of best practices around gender equality in general and family policy in particular, for liberal welfare states (Australia, Canada, New Zealand, UK, USA), IOs are still less authoritative than the national level when it comes to on-the-ground policymaking.
Conceptualizing National Family Policies: A Capabilities Approach
Authors: Javornik Jana , Yerkes Mara A. 
Published: December 2020

AbstractComparative family policy research has advanced significantly in recent years. The growing availability of more and better data have improved our understanding of cross-national similarities and differences in family policies, as well as how they shape the lives of different families. Despite these advancements, comparative family policy research continues to face difficulties. The multifaceted nature of family policies makes cross-country comparisons complex. Conceptualizing our theoretical understanding of which policy aspects matter and why as well as operationalizing them into measurable indicators, often remains problematic for comparative analyses. Using examples of British and Swedish policies on childcare, a policy area particularly prone to conceptual challenges, we discuss the difficulties involved in conceptualizing family policies in comparative research. We argue that taking a capabilities approach provides a useful way forward in the field and show how such a conceptual framework allows us to more meaningfully analyze both work-family policies and their outcomes.