bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Depresión inducida por cannabis?. A propósito de un caso
Authors:   Hospital Infanta Leonor, Madrid, Rubio Corgo Sandra , Matas Ochoa Aurelia Maria ,   Hospital Infanta Leonor, Madrid, Alvarez Astorga Aldara ,   Hospital Infanta Leonor, Madrid, Pérez Vicente Estefanía ,   Hospital Infanta Leonor, Madrid, Sanchez Gordillo Clara ,   Hospital Infanta Leonor, Madrid
Published: November 2020

1.	Descripción precisa de los objetivos Existe gran controversia respecto al cannabis, por un lado hay numerosos artículos sobre las consecuencias psicopatológicas que puede producir, y por otro sobre su uso terapéutico. Mediante la exposición de un caso clínico abordaremos la posible relación entre el consumo de cannabis y sintomatología depresiva 2.	Material y métodos Descripción de un caso clínico y revisión bibliográfica 3.	Resultados y conclusiones Presentamos un varón de 15 años que estuvo consumiendo cannabis 6-7 porros de forma diaria durante un año, asegura que se mantiene abstinente desde hace 1 mes. En la exploración psicopatológica destaca afecto lábil, hipotimia, apatía, anhedonia, autoconcepto negativo, sentimientos de minusvalía, insomnio de conciliación, hipoproxesia, prospección de futuro negativa, ideas pasivas de muerte, niega ideación autolítica activa, no presenta sintomatología psicótica. La clínica descrita le repercute en su rendimiento académico (cursa 4º ESO) y en sus relaciones sociales. Refiere que se siente así desde hace meses siendo uno de los motivos por los que ha abandonado el consumo. Pruebas complementarias sin hallazgos. Con la introducción de Sertralina a dosis progresiva se mitigan los síntomas, manteniéndose estable en la actualidad. El cuadro clínico descrito es congruente con Trastorno Depresivo inducido por una sustancia, no existiendo código específico para el cannabis ni en la CIE-10 ni en DSM-V, en contraposición con otros tóxicos. Los estudios de seguimiento revisados evidencian la relación entre consumo de cannabis y síntomas depresivos en inicio de consumo antes de los 15 años y con una frecuencia superior a 1vez/semana, siendo la misma conclusión en un metaanálisis. Sin embargo, en varios estudios realizados en adultos no se halla esa correlación, en probable relación con la eliminación del factor de inicio precoz. Lo que explica que en las guías clínicas no se incluya un ítem específico.
Thomas Hobbes és a természeti állapot dilemmái I.
Authors: Nagy Levente 
Published: November 2020

The purpose of this paper is to reflect on some the ideas of Thomas Hobbes, one of the foundersof modern political philosophy, best known for his masterpiece, Leviathan. The aim of this essayis not to provide a full scale analysis of Hobbes’ main work, nor to present his moral or politicalphilosophy, nor to reflect on the significance of his impact on later political thinkers. The aim ismore modest, and the theme under scrutiny is more narrow: the paper is devoted to a criticalanalysis of the main premise (state of the nature) of Hobbes’ theory of power, including theambivalent character of the state of nature, as well as the logical dilemmas that arise duringthe analysis.
After a general presentation of Hobbes’s philosophy and of the logical construction of hiswork, I will tend to focus on two aspects of the state of nature: firstly, I will analyse the assumedanalogy between the state of nature and the Book of Genesis; secondly, I will examine whetherthe „war of all against all” is an axiomatic outcome of the „primitive” state. It turns out, that theanswers for these questions are not so unanbiguous.
STATE OF PROSTHETIC BED TISSUES AND LONG-TERM RESULTS OF DENTAL PROSTHETICS IN PATIENTS WITH DISEASES OF THE HEPATOBILIARY SYSTEM
Authors: Koshelev konstantin , Belousov Nikolay , Pushkareva Ekaterina , Baranov Ilya 
Published: November 2020

Background. Predicting the immediate and long-term results of treatment is an urgent problem of modern medicine. The prognosis of complex dental treatment is influenced by many factors. Among the main ones: features of the individual's anatomy and physiology, the type and method of the chosen treatment, the doctor's qualification, features of the patient's psychological profile, the presence of concomitant pathology, and so on. Each of the factors must be considered separately to understand the mechanism and the strength of its impact.
Relevance. Finding out the influence of diseases of the hepatobiliary system on the prognosis of dental orthopedic treatment.
Objectives. We studied the indicators of patients who re-applied for replacement of an existing dental prosthesis. The study group consisted of patients with liver and biliary tract diseases, and the control group consisted of patients without concomitant General somatic pathology. The terms of use of the prosthesis, the number and severity of treatment complications, and the state of the prosthetic bed were evaluated. Standard clinical and paraclinical diagnostic methods, corresponding pathology, cone-beam computed tomography and statistical analysis methods were used as research methods.
Results. The correlation of the terms of use of various types of dentures with the presence of liver and biliary tract diseases in the anamnesis was determined. The dependence of the structure of bone tissue and its density on the presence of the considered pathology was revealed.
Conclusion. The obtained data can be applied by orthopedic dentists in the near and long-term prognosis of the result of treatment of patients with partial loss of teeth and concomitant diseases of the hepatobiliary system.
EXPERIMENTAL SUBSTANTIATION OF PARODONTROTECTOR EFFICIENCY OF THE COMPLEX OF DRUGS IN RATS WITH TYPE 2 DIABETES DURING ORTHODONTIC TEETH RELOCATION
Authors: Dem'yanenko Svetlana , Morozova Marina , Morozov Andrey , Denga Anastasiya , Makarenko Olga 
Published: November 2020

Introduction. Pathological changes in the periodontium in people with diabetes mellitus, according to some data, are aggravated after orthodontic intervention, which dictates the need to carry out preventive measures, the effectiveness of which will determine the quality of orthodontic treatment.
The aim of this study was to study the periodontal protective effect of two domestic antidisbiotic drugs containing plant extracts, vitamins, calcium and phosphorus salts.
Methodology. The experiments were carried out on white Wistar rats, divided into 5 groups. The gums and periodontal bone tissue were isolated. The activity of urease, lysozyme and the content of hyaluronic acid was determined in the gingival homogenate, and the degree of dysbiosis was calculated. In the homogenate of the periodontal bone tissue, the activity of alkaline and acid phosphatases was determined, the mineralization index and the degree of mineralization, as well as the content of calcium and protein, were calculated.
Results. The obtained results of our study have convincingly proved the pronounced periodontal protection efficacy of antidisbiotic drugs for oral applications of the plates "CM-2" and the drug Enoant polyphenols. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis, along with the manifestation of pronounced adaptogenic, antimicrobial and periodontal protective effects in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement.
Conclusion. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. The obtained results of the experimental study serve as the basis for the recommendation of the investigated complex, including the local application of plates with herbal extracts, vitamins, calcium and microelements, along with the systemic use of grape polyphenol concentrate, in an orthodontic clinic for patients with diabetes mellitus.
FORMATION OF THE GINGIVAL RECESSION IN PATIENTS WITH BRUXISM
Authors: Saleeva Gul'shat , Saleev Rinat , Mustakimova Rezeda , Saleeva Lyaysan 
Published: November 2020

Subject. Despite the data on the polyetiology of gum recession, the role of some factors in its formation remains unknown, which does not allow to adequately develop methods for the prevention of this disease.
The aim of this study was to assess the effect of bruxism on the formation of gingival margin recession.
Methodology. The study was based on data, obtained during the examination of 65 patients aged 20 to 40 years with a of bruxism, established by a neurologist. The control group consisted of 65 conditionally healthy patients of the same age without neurological pathology and with intact periodontal disease. The study excluded individuals with other etiological factors that can lead to gingival recession.
Result. According to the results of the study, a 1 year later, the occurrence of gingival recession was determined in 44.7 % of cases, after 2 years, the number of recessions was determined in 64.7 %, and after 36 months in 77 % of cases. At the same time, the periodontal condition in relation to the formation of recessions remained unchanged in the patients of the comparison group. In all cases, recession was determined by the oral surface of the lower incisors, in 80 % of patients, on the vestibular surface of the canines and bicuspid of both jaws.
Conclusions: In patients with bruxism, there is a gradual formation of gingival recession with a predominant localization in the area of the oral surface of the incisors in the lower jaw, and on the vestibular surface of the canines and the buccal surface of the bicuspid.
PAMALI CULTURE OF POLEWALI COMMUNITY IN WEST SULAWESI AND APPRECIATION OF ISLAMIC JURISPRUDENCE
Authors: Sadat Anwar , Yusuf Muhammad 
Published: November 2020

The article explores the values of the local wisdom (‘urf) of the West Sulawesi Polewali community and an appreciation of Islamic law towards it. This research used a qualitative approach. Data collection was done through triangulation techniques that were intended to obtain more complete data. Data were analyzed with content analysis techniques and semiotics analysis approach. Content analysis can provide closer philosophical meaning of the phrase. While the semiotics approach can help to understand the meaning of the symbolic expressions of Pamali. The phrases in Pamali contain very deep and philosophical meanings. This research showed that Pamali has a depth of meaning so that a symbolic and contextual analysis approaches can give exact meaning of Pamali expression. Thus, the local wisdom in muamalat can be considered in formulating Islamic law that applies to the Mandar community in general and the Polewali community in particular. Local wisdom in the Polewali community can be used as a consideration in the formulation of Islamic law and development policies in Polewali. Artikel ini mengupas tentang nilai-nilai kearifan local (‘urf) masyarakat Polewali Sulawesi Barat dan apresiasi hukum Islam terhadapnya. Penelitian ini menggunakan pendekatan kualitatif. Pengumpulan data dilakukan melalui teknik triangulasi yang bertujuan untuk memperoleh data yang lebih lengkap. Data dianalisis dengan teknik analisis isi dan pendekatan analisis semiotika. Hal itu karena pesan di dalam Pamali menggunakan bahasa simbolik untuk tujuan tertentu. Analisis isi dapat lebih mendekatkan pada makna filosofis dari ungkapan. Sedangkan pendekatan semiotika dapat membantu untuk memahami makna ungkapan simbolik Pamali. Ungkapan pada Pamali mengandung makna yang sangat dalam dan filosofis. Hasil penelitian menunjukkan bahwa Pamali memiliki makna yang dalam sehingga hanya dengan pendekatan analisis simbolik dan kontekstual dapat menempatkan makna ungkapan Pamali secara tepat. Dengan demikian, kearifan lokal dalam muamalat itu dapat menjadi pertimbangan dalam merumuskan hukum Islam yang berlaku bagi masyarakat Mandar umumnya dan masyarakat Polewali pada khususnya. Kearifan lokal pada masyarakat Polewali memungkinkan untuk dijadikan pertimbangan dalam perumusan hukum Islam dan kebijakan pembangunan di Polewali.
Efectos de la reactivación económica en Colombia
Authors: Vallejo Zamudio Luis E. 
Published: November 2020

La crisis económica que afronta Colombia por cuenta de la pandemia del coronavirus es de proporciones gigantescas. Las expectativas de reactivación de los distintos sectores económicos son crecientes. Si bien es cierto que se observó un repunte en mayo en comparación con el mes de abril, las estadísticas divulgadas por el Departamento Nacional de Estadística (DANE) para el primer semestre del año en curso son dramáticas. El DANE pronostica que la producción al finalizar el 2020 descenderá un 10 % y el empleo, un 20 %.
Adherence to Antihypertensive Therapy: A Systematic Review of Russian Prospective Studies from 2000 to 2019
Authors: Bochkareva E. V. , Butina E. K. , Kim I. V. , Kontsevaya A. V. , Drapkina O. M. 
Published: November 2020

Russia belongs to countries with a high prevalence of arterial hypertension (AH), which is the main cause of premature death in the Russian population. The level of blood pressure (BP) is controlled in less than a third of patients, which may be due to poor adherence to medical recommendations and irregular medication. The manuscript provides a review of studies evaluating the effectiveness of measures to improve adherence to antihypertensive therapy (AHT).Aim. To prepare a systematic review of Russian studies to assess the effectiveness of measures to increase adherence to AHT, to determine/describe the main directions of the intervention and the methodological level.Material and methods. The search for full-text articles on adherence to AHT published in Russian in the period from 2000 to 2019 was carried out in the main Russian and international electronic databases eLIBRARY.ru, Embase, Russian Medicine, MEDLINE. Of the 563 publications found, 20 were included in the review.Results. In 14 studies, adherence was assessed using the 4-item Morisky Medication Adherence Scale (MMAS-4), other studies used bespoke questionnaires or pill counts. Two studies examined factors associated with adherence. The observation period was up 6 weeks to 12 months, the number of participants is 30-2435 people. A higher adherence was noted in women, people over 50 years old, with higher education, working, with concomitant diabetes mellitus and a history of myocardial infarction. Patient education was effective interventions to improve adherence (in particular, in studies, improvement on the MMAS-4 from 1.8 to 3.9 points, p=0.0002 or from 2.80 to 3.79 points, p<0.0001), telephone reminders (p<0.0001), training in self-measurement of blood pressure (p<0.05) and fixed combinations of drugs (p<0.05).Conclusion. The most effective ways to improve adherence are patient education and the use of drugs fixed combinations. In most studies, subjective methods of adherence assessing were used.
An Acute Osteochondral Defect Secondary to Fabella Impaction
Authors: Dekker Travis J. , DePhillipo Nicholas N. , Kennedy Mitchell Iung , Aman Zachary S. , LaPrade Robert F. 
Published: November 2020

Case:
A healthy 37-year-old man sustained a knee injury after performing a deep flexion maneuver while skiing and noted immediate knee pain and swelling. Because of persistent inability to fully extend his knee and persistent posterolateral knee pain, he was evaluated and noted to have an acute osteochondral defect of the posterolateral femoral condyle directly adjacent to his fabella. After a trial of nonoperative interventions, he elected to undergo an arthroscopic-assisted open excision of the fabella and a chondroplasty of the posterolateral femoral condyle defect.

Conclusion:
A traumatic osteochondral defect secondary to a lateral fabella impaction is a rare pathology but must be evaluated in patients performing deep flexion maneuvers who have persistent knee pain and mechanical symptoms. When there is a focal defect with increased edema of both the fabella and posterolateral femoral condyle, an arthroscopic chondroplasty and fabella excision is a valid treatment to return the patient back to desired activities.
Recruitment patterns in a large international randomized controlled trial of perioperative care in cancer patients.
Authors: Gazendam Aaron , Bozzo Anthony , Schneider Patricia , Giglio Victoria , Wilson David , Ghert Michelle 
Published: November 2020

Abstract
Introduction: The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) randomized controlled trial (RCT) was the first study to prospectively enroll and randomize orthopaedic oncology patients in multiple centers internationally. The objective of this study was to describe recruitment patterns, examine the differences in enrollment across different PARITY sites, and to identify variables associated with differing levels of recruitment.Methods: Data from this study was obtained from the PARITY trial Methods Center and records of correspondence between the Methods Center and recruiting sites. We performed descriptive statistics to report the recruitment patterns over time. We compared recruitment, time to set up, and time to enroll the first patient between North American and international sites, private and public health care models, and the presence or absence of research personnel. Two-tailed non-paired t-tests were performed to test average monthly recruitment rates between groups. Results: A total of 602 patients from 36 North American and 12 international sites were recruited from 2013 to 2019. Average monthly enrollment increased each year of the study. North American sites were able to start up significantly faster than international sites (19.5 vs. 27.0 months p=0.04). However, international sites had a significantly higher recruitment rate once active (0.2 participants/month vs. 0.59 participants/month, p=0.023). Sites with research personnel were able to reach ‘enrolment ready’ status significantly faster than sites without research personnel (19.3 vs. 30.3 months, p=0.032), but there was no difference in recruitment once active (0.28 participants/month vs. 0.2 participants/month). Publicly funded sites were to recruit significantly more patients compared to private institutions (0.4/month vs. 0.17/month, p=0.03).Conclusions: As a collaborative group, the PARITY investigators increased the pace of recruitment throughout the trial, likely by increasing the number of active sites. The longer time to start-up at international sites may be due to the complex governing regulations of pharmaceutical trials. Nevertheless, international sites should be considered essential as they recruited significantly more patients per month once active. The absence of research support personnel may lead to delays in time to start up. The results of the current study will provide guidance for choosing which sites to recruit for participation in future collaborative clinical trials in orthopaedic oncology and other surgical specialties.Trial Registration: ClinicalTrials.gov NCT01479283. Prospectively registered on November 24, 2011.
A Novel Immune Classification Reveals Distinct Immune Escape Mechanism and Genomic Alterations: Implications for Immunotherapy in Hepatocellular Carcinoma
Authors: Liu Zaoqu , Zhang Yuyuan , Shi Chengcheng , Zhou Xueliang , Xu Kaihao , Jiao Dechao , Sun Zhenqiang , Han Xinwei 
Published: November 2020

Abstract
Background: The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by which TIME affects immunotherapy have not been elucidated in hepatocellular carcinoma (HCC).Methods: A total of 2195 eligible HCC patients from TCGA and GEO database were collected. We comprehensively explored the different heterogeneous TIME phenotypes and its clinical significance. The potential immune escape mechanisms and what genomic alterations may drive the formation of different phenotypes were further investigated.Results: We identified three phenotypes in HCC: TIME-1, the “immune-deficiency” phenotype, with immune cell depletion and proliferation; TIME-2, the “immune-suppressed” phenotype, with being in immunosuppressive states; TIME-3, the “immune-activated phenotype”, with abundant leukocytes infiltration and immune activation. The prognosis and sensitivity to both sorafenib and immunotherapy differed among the three phenotypes. We also underlined the potential immune escape mechanisms: lack of leukocytes and defective tumor antigen presentation capacity in TIME-1, increased immunosuppressive cells in TIME-2, and rich in immunoinhibitory molecules in TIME-3. The different phenotypes also demonstrated specific genomic events: TIME-1 characterized by TP53, CDKN2A, CTNNB1, AXIN1 and FOXD4 alterations; TIME-2 characterized by significant alteration patterns in the PI3K pathway; TIME-3 characterized by ARID1A mutation. Besides, the TIME index (TI) was proposed to quantify TIME infiltration pattern, and it was a superior prognostic and immunotherapy predictor. A pipeline was developed to classify single patient into one of these three subtypes and calculated the TI. Conclusions: We identified three TIME phenotypes with different clinical outcomes, immune escape mechanisms and genomic alterations in HCC, which could present strategies for improving the efficacy of immunotherapy. TI as a novel prognostic and immunotherapeutic signature that could guide personalized immunotherapy and clinical management of HCC.
ADT-OH exhibits anti-metastatic activity on malignant melanoma through inhibition of FAK/Paxillin signaling pathways
Authors: Cai Fangfang , Xu Huangru , Yu Shihui , Li Ping , Lu Yanyan , Chen Jia , Bi Zhiqian , Sun Huisong , Cheng Jian , Zhuang Hongqin , Hua Zi-Chun 
Published: November 2020

Abstract
Background: Melanoma is a highly aggressive cancer, and its high metastasis results in a high lethality. Hydrogen sulfide (H2S) is now widely recognized as the third endogenous gas delivery substance and may play a key role in cancer biological processes. The present study was designed to evaluate the anti-metastatic effect of H2S-donor ADT-OH on melanoma cells and the underlying mechanism.Methods: Firstly, the effect of ADT-OH on the migration of melanoma cells was explored in vivo by the mouse footpad injection model and the mouse tail vein metastasis model. Tumor xenograft growth and tumor tissue H&E analyses were also measured in vivo. Then, the migration inhibitory effect and the underlying mechanism of ADT-OH on B16F10, B16F1 and A375 melanoma cell lines were evaluated by wound healing, transwell, western blot and immunofluorescence analyses. Results: Our data showed that ADT-OH inhibited the migration and invasion of melanoma cells significantly in vivo in three different animal models. Further research showed that ADT-OH significantly suppressed the migratory, invasive and adhesive properties of A375 and B16F10 cells as measured by the wound-healing and transwell assays. Mechanistically, ADT-OH treatment suppressed the EMT processes and reduced the enzymatic activity of FAK and Paxillin. Moreover, abnormal CSE/CBS and AKT signaling pathways in A375 and B16F10 cells were notably observed following ADT-OH treatment. Additionally, ADT-OH at higher concentration significantly inhibited the proliferation of highly metastatic melanoma A375 and B16F10 cells.Conclusions: Our results suggest that ADT-OH exerts anti-metastasis activity in melanoma cells by suppressing the EMT process through the CSE/CBS and FAK signaling pathways, and it might be used as an agent against metastatic melanoma in future.