bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long noncoding RNA MALAT1 can regulate proliferation and apoptosis of LPS-treated HK-2 cells via targeting miR-23a-3p through regulating ERK signaling
Authors: Li Jinxia , Liu Haibo , Li Chao 
Published: May 2020

IntroductionThe aim of the present study was to investigate the roles of long noncoding RNA (lncRNA) MALAT1 in the development of sepsis-induced acute kidney injury (septic AKI) and the underlying mechanism.Material and methodsThe levels of MALAT1 in the serum of the septic AKI patients and healthy subjects were compared, and the targeting relationship between MALAT1 and miR-23a-3p was analyzed. Moreover, the effects of MALAT1 and miR-23a-3p on the proliferation and apoptosis of LPS-treated HK-2 cells were analyzed. Finally, the roles of ERK signaling during this process were analyzed.ResultsWe found that MALAT1 was markedly increased in serum of the septic AKI patients and LPS-treated cells. In addition, overexpression of MALAT1 relieved the injury induced by LPS in RMCs. Moreover, miR-23-a-3p has been confirmed as a target of MALAT1. Meanwhile, we also found that MALAT1 siRNA can increase the proliferation and inhibit the apoptosis of LPS-treated HK-2 cells through activating ERK signaling, and knockdown of miR-23a-3p can partially block the anti-apoptotic effect of MALAT1 siRNA.ConclusionsWe report that MALAT1 can regulate the proliferation and apoptosis of LPS-treated HK-2 cells via targeting miR-23a-3p through regulating ERK signaling, suggesting that the MALAT1/miR-23a-3p axis could serve as a potential therapeutic target for the treatment of septic AKI.
The impact of thinking about supportive relationships on interpersonal defensiveness. Does it matter who thinks, about whom, and in what way?
Authors: Kuncewicz Dariusz 
Published: May 2020

BackgroundThe aim of this study was to test the effects of thinking about supportive relationships on interpersonal defensiveness among participants with different levels of attachment security. The effects were examined depending on closeness with a visualized person and an ecosystem or egosystem perspective of thinking about him/her.Participants and procedureAfter taking the bogus emotional intelligence test and completing the attachment questionnaire, the participants (N = 124) visual-ized an acquaintance or a close person, adopting the ecosystem or the egosystem perspective on thinking about him/her. Subse-quently the participants received unfavorable feedback on their bogus test results and completed measures of defensiveness in an anticipated conversation with the researcher.ResultsThe high-securely attached individuals reported less comfort in an anticipated conversation with the researcher after close well-wishing person visualization than after well-wishing acquaintance visualization. The low-securely attached participants showed greater emotional openness to the researcher after ecosystem thinking about any well-wishing person than after egosystem thinking.ConclusionsThe key results suggest that some aspects of interpersonal defensiveness among insecurely attached people can be reduced by a shift from an ego- to an ecosystem perspective of thinking about their relationships. In the next research step, it seems espe-cially important to explore whether therapeutic work focusing on ecosystem orientation can overcome the attachment problems in relationships.
Well-being and health perception of university students in Portugal: the influence of parental support and love relationship
Authors: Alves Regina , Precioso José , Becoña Elisardo 
Published: May 2020

BackgroundThe mental health of university students has been the subject of great attention from scientific investigations, not only to provide contextualised information, but additionally since high levels of well-being predicted a quality education. This study aims to evaluate the perception of well-being and health of university students, exploring the psychometric properties of the Well-being and Health Perception Scale (WbHPS) and analysing the influence of sociodemographic variables.Participants and procedureA questionnaire was applied to a representative sample of 840 university students in Portugal stratified by year of academic attendance and scientific area of study. The WbHPS consists of 5 items measured on a 5-point Likert scale. We considered as explanatory variables the year of study and scientific area, sex, age, love rela-tionship, professional situation and BMI.ResultsThe WbHPS showed good psychometric properties, indicating the presence of an explanatory factor of 58.45% of variance and a good internal consistency (α = .81). The obtained results identified WbHPS as being inde-pendently associated with being in a love relationship, having a normal weight and not being displaced after starting at university.ConclusionsIt is necessary to (re)think about disease prevention and health promotion actions in higher education, with psy-chosocial interventions that truly reflect on the well-being and health of university students.
Safety and efficacy analysis of microwave ablation in small hepatocellular carcinomas sized below 3 cm
Authors: Piskin Ferhat C. , Balli Huseyin T. , Aikimbaev Kairgeldy 
Published: May 2020

PurposeThe aim of this study was to investigate the efficacy and safety of microwave ablation (MWA) in small hepatocellular carcinomas sized ≤ 3 cm, determine long-term survival, and identify prognostic factors for survival rates.Material and methodsIn this study, the radiological and laboratory findings obtained from 31 consecutive patients who underwent MWA were retrospectively evaluated. The survival periods and complication rates were analysed.ResultsMicrowave ablation was applied to 42 hepatocellular carcinoma nodules in 31 patients. The mean age of the patients was 61 ± 7.3 (median 62, range 46-78) years. The mean overall survival (OS) was 47.4 ± 3.3 months. The rates of cumulative OS in the first, second, and third years were 95.2%, 91.8%, and 79.2%, respectively. The mean disease-free survival (DFS) rate was 24.1 ± 2.5 months. The cumulative DFS rates in the first, second, and third years were 75.6%, 52.5%, and 28.2%, respectively. The number of tumours and tumour distribution were determined as prognostic factors. No major complication was detected, but six patients (13.9%) developed minor complications after MWA.ConclusionsMicrowave ablation in patients with hepatocellular carcinoma is a safety treatment modality with very low rates of complications. It offers an effective treatment with a high rate of complete response and local disease control according to the short-term results. In the long term, it prolongs the survival time of the treated patients. The number of tumours and tumour distribution were determined as prognostic factors affecting survival rates.
The contribution of diet preference to the disease course in children with familial Mediterranean fever: a cross-sectional study
Authors: Kisla Ekinci Rabia Miray , Balcı Sibel , Bisgin Atıl , Cetin Fatma , Tumgor Gokhan 
Published: May 2020

ObjectivesFamilial Mediterranean fever (FMF) is characterized by recurrent, self-limiting attacks of fever and serositis. Nutrition is very important in the management of chronic diseases. Previous studies suggested that salty and fatty diet cause inflammation, therefore we aimed to investigate the effects of dietary self-efficacy and behavior about low-salt or low-fat diet on disease course in children with FMF.Material and methodsThis cross-sectional study included patients aged between 10–18 years, diagnosed in our department and admitted between June 2019 and September 2019. Demographic and clinical properties were obtained from the medical files of the patients. Children’s Dietary Self-Efficacy Scale (CDSS) and Health Behavior Questionnaire (HBQ) – Diet Behavior Scale (DBS) were performed for dietary self-efficacy and behavior about preferring low-salt or low-fat diet. Clinical features were compared between patients, which were grouped according to the sum of these two scales, with a cut-off score of 5.ResultsThe mean age of 74 FMF patients (44 females, 34 males), included in the study, was 14.6 ±2.82 years. Median CDSS and DBS scores of the patients were 5 (minimum –6, maximum 14) and 0 (minimum –10, maximum 12), respectively. According to the sum of these two scales, 39 (52.7%) patients who had scored at least 5, had a statistically higher rate of complete response to colchicine. The remaining clinical parameters were similar between these two groups.ConclusionsLow-salt or low-fat diet may be an adjuvant modification in the management of children with FMF. Further studies are needed to clarify the role of low-salt or low-fat diet in FMF pathogenesis.
2020/2 Introduction of 25 years as maximum age for participation in air traffic controllers recruiting process found unjustified (BE)
Authors: Busschaert Gautier 
Published: May 2020

2020/2 Introduction of 25 years as maximum age for participation in air traffic controllers recruiting process found unjustified (BE)
Relying on the prohibition of age discrimination stemming from Directive 2000/78, the Brussels Labour Tribunal, in a judgment of 28 November 2019, ruled that an age limit of 25 for the recruitment of air traffic controllers constituted direct discrimination. Its decision was grounded on the fact that even if there are objective reasons related to air traffic safety which may justify setting an age limit for applicants, the employer must adduce concrete evidence based on scientific facts.
2020/4 Admissibility of Employers’ Requirements regarding Religious Symbols in Workplace (GE)
Authors: Dressel Caroline 
Published: May 2020

2020/4 Admissibility of Employers’ Requirements regarding Religious Symbols in Workplace (GE)
Many national decisions in Germany in the past had to deal with employers’ requirements regarding religious symbols in the workplace. Also, in 2017, the ECJ has dealt with two matters of such. Whilst the ECJ strictly refers to the principles of entrepreneurial freedom, the Federal Labour Court (Bundesarbeitsgericht, the ‘BAG’) tends to give priority to religious freedom. Last year, the BAG appealed to the ECJ for final clarification, in particular regarding the relationship between the basic rights of entrepreneurs and the constitutional right to religious freedom, by way of a preliminary ruling procedure with its decision dated 30 January 2019.
2020/5 An undefined number of consecutive fixed-term contracts for the duration of 12 years does not necessarily violate EU law (AT)
Authors: Kager Ines 
Published: May 2020

2020/5 An undefined number of consecutive fixed-term contracts for the duration of 12 years does not necessarily violate EU law (AT/EU)
On 3 October 2019, in case C-274/18 (Schuch-Ghannadan), the ECJ held that a national regulation, which provides for different maximum total durations of successive fixed-term employment contracts for part-time workers on the one hand and full-time workers on the other, could result in a discrimination of part-time workers and an indirect discrimination of women.
2020/11 Whistleblowing dismissal unfair where decision-maker was manipulated by another manager (UK)
Authors: Lister Richard 
Published: May 2020

2020/11 Whistleblowing dismissal unfair where decision-maker was manipulated by another manager (UK)
In a decision with implications for unfair dismissal law generally, the UK’s Supreme Court (SC) ruled that it is not always necessary for a dismissing manager to know about whistleblowing disclosures made by an employee in order for that dismissal to be automatically unfair.
2020/12 The legal position of bicycle deliverers in Austria (AT)
Authors: Dullinger Thomas 
Published: May 2020

2020/12 The legal position of bicycle deliverers in Austria (AT)
In Austria, a collective bargaining agreement (CBA) for bicycle deliverers has been in force since 1 January 2020. According to the contracting parties (the Austrian Chamber of Commerce and the Austrian Trade Union Federation), it is the first of its kind worldwide. https://www.vida.at/cms/S03/S03_4.8.a/1342616918551/kollektivvertrag/strasse/weltweit-erster-kv-fuer-fahrradboten-abgeschlossen. On this occasion, this article examines the legal basis for employment in this sector and whether this long-awaited step will really lead to an improvement for bicycle deliverers.
“Don‘t Let Nobody Bother Yo’ Principle”
Authors: Davis Adrienne D. 
Published: May 2020

The organizing essay of the collection presents the important concept of sexual economy of slavery. It examines the ways that slavery's sexual and racial subordination converged around the bodies of enslaved black women. It documents slavery as a "sexual political economy" to make explicit the connections between its markets, labor structure, and sexual exploitation. It designates slavery a sexual economy to foreground slavery's gender hierarchies and mechanisms of subordination as well as to show how slavery offered early illustrations of the social construction and fluidity of gender and the false dichotomy between public and private relations. In sum, the chapter demonstrates that race, sex, and slavery combined to produce an entirely different notion of intimacy and sexual anxieties and how those were managed and reproduced.
On Being a Black Sexual Intellectual
Authors: Nixon Angelique V. 
Published: May 2020

This chapter provides a critical reading of Cheryl Clarke's second volume of poetry, Living as a Lesbian. Situating this text within the larger context of black women's poetry, Green argues that its erotic aesthetic works to critique the historic erasure of the black lesbian body in the discourse of African American life as it simultaneously pushes toward and away from theories of sexuality that limit and thus reduce black women’s linguistic economies to metaphors of sexual desire.
Legislating Nonmarital Sex in India, 1911–1929
Authors: Tambe Ashwini 
Published: May 2020

The third chapter describes how an expanded understanding of girlhood influenced an Indian law restricting child marriage and raising the age of consent. This chapter details changes in legislative politics and in the way Indian legislators appropriated international antitrafficking standards across two decades. It begins by discussing the 1911 Dadabhoy Bill, the first formulation of a distinct age of consent for all nonmarital sex, which was partially provoked by conventions drawn up by the International Society for the Suppression of White Slave Traffic. Next, the chapter examines how Indian Legislative Assembly members in 1922 and 1923-24 responded to the claims S. M. Edwardes made to League of Nations delegates justifying a lower age of consent in India. It then analyzes the 1929 law restricting child marriage, focusing on its effects on sexual consent outside marriage and the resulting anxieties pertaining to parental control. It closes with a fuller analysis of the Report of the Age of Consent Committee and its articulation of parental anxieties. The chapter argues that the 1929 law constraining child marriage, widely considered a key moment of Indian social reform, was facilitated by prior and concurrent measures that fixed a higher age of consent for nonmarital sex. These measures entrenched parental control over daughters’ sexual practices and, ultimately, limited the implications of marriage reform.
Serum neurofilament light chain in FTLD: association with C9orf72, clinical phenotype, and prognosis
Authors: Cajanus Antti , Katisko Kasper , Kontkanen Aleksi , Jääskeläinen Olli , Hartikainen Päivi , Haapasalo Annakaisa , Herukka Sanna‐Kaisa , Vanninen Ritva , Solje Eino , Hall Anette , Remes Anne M. 
Published: May 2020

AbstractObjectiveThe aim of the present study was to compare the levels of serum neurofilament light chain (sNfL) in frontotemporal lobar degeneration (FTLD) patients of different clinical subtypes (bvFTD, PPA, and FTLD‐MND) and with or without the C9orf72 repeat expansion, and to correlate sNfL levels to disease progression, assessed by the brain atrophy rate and survival time.MethodsThe sNfL levels were determined from 78 FTLD patients (C9orf72 repeat expansion carriers [n = 26] and non‐carriers [n = 52]) with Single Molecule Array (SIMOA). The progression of brain atrophy was evaluated using repeated T1‐weighted MRI scans and the survival time from medical records.ResultsIn the total FTLD cohort, sNfL levels were significantly higher in C9orf72 repeat expansion carriers compared to non‐carriers. Considering clinical phenotypes, sNfL levels were higher in the C9orf72 repeat expansion carriers than in the non‐carriers in bvFTD and PPA groups. Furthermore, sNfL levels were the highest in the FTLD‐MND group (median 105 pg/mL) and the lowest in the bvFTD group (median 27 pg/mL). Higher sNfL levels significantly correlated with frontal cortical atrophy rate and subcortical grey matter atrophy rate. The higher sNfL levels also associated with shorter survival time.InterpretationOur results indicate that the C9orf72 repeat expansion carriers show elevated sNFL levels compared to non‐carriers and that the levels differ among different clinical phenotypes of FTLD. Higher sNfL levels correlated with a shorter survival time and cortical and subcortical atrophy rates. Thus, sNfL could prove as a potential prognostic biomarker in FTLD.
Comparison of soil sampling techniques for alkaline hydrolyzable‐nitrogen on clay soils
Authors: Davidson Jarom T. , Roberts Trenton L. , Hardke Jarrod T. , Slaton Nathan A. , Fulford Anthony M. 
Published: May 2020

AbstractThe Nitrogen‐Soil Test for Rice (N‐STaR) provides a site‐specific N rate recommendation by quantifying alkaline hydrolyzable‐N (AH‐N). A user‐friendly method for obtaining a representative N‐STaR soil sample is needed, and this study was designed to evaluate the performance of alternative sampling techniques compared with the Dutch auger (DA). The alternative techniques included a Kleen Hole Spade dry (KHS‐D), a KHS lubricated with water (KHS‐W), a KHS lubricated with WD‐40 (KHS‐40), and the N‐STaR Bucket and Drill (BD). One soil sample was collected with each sampling technique from four blocks and was repeated across 14 sites. Each sample was analyzed for AH‐N using N‐STaR and compared against the DA. Variability in AH‐N ranged from a coefficient of variation (CV) of 4.4% at Site 3 to 22.3% at Site 5. The AH‐N at 13 of the 14 sites had no significant differences among sampling techniques. At Site 14, the AH‐N measured using the KHS‐40 was statistically higher than the DA by 25 mg AH‐N kg soil–1 and would correspond to a fertilizer N rate difference of 49 kg N ha–1. The KHS‐D probe appears to have the greatest accuracy and precision compared to the DA, although the KHS‐W, KHS‐40, and the BD produce similar results. All alternative techniques averaged a numerically higher AH‐N value than the DA but were not statistically different for 55 of the 56 observations. Therefore, these alternative soil sampling methods can be used successfully to collect soil samples for N‐STaR analysis on clayey soils.
Sex differences in daily activity intensity and energy expenditure and their relationship to cortisol among BaYaka foragers from the Congo Basin
Authors: Sarma Mallika S. , Boyette Adam H. , Lew‐Levy Sheina , Miegakanda Valchy , Kilius Erica , Samson David R. , Gettler Lee T. 
Published: May 2020

AbstractObjectivesThe pooling of energetic resources and food sharing have been widely documented among hunter‐gatherer societies. Much less is known about how the energetic costs of daily activities are distributed across individuals in such groups, including between women and men. Moreover, the metabolic physiological correlates of those activities and costs are relatively understudied.Materials and methodsHere, we tracked physical activity, energy expenditure (EE), and cortisol production among Congo Basin BaYaka foragers engaged in a variety of daily subsistence activities (n = 37). Given its role in energy mobilization, we measured overall daily cortisol production and short‐term cortisol reactivity through saliva sampling; we measured physical activity levels and total EE via the wGT3X‐bt actigraph and heart rate monitor.ResultsWe found that there were no sex differences in likelihood of working in common activity locations (forest, garden, house). Across the day, women spent greater percentage time in moderate‐to‐vigorous physical activity (%MVPA) and had lower total EE than men. Females with higher EE (kCal/hr) produced greater cortisol throughout the day. Though not statistically significant, we also found that individuals with greater %MVPA had larger decreases in cortisol reactivity.DiscussionBaYaka women sustained higher levels of physical activity but incurred lower energetic costs than men, even after factoring in sex differences in body composition. Our findings suggest that the distribution of physical activity demands and costs are relevant to discussions regarding how labor is divided and community energy budgets take shape in such settings.
Direct Observation of Aggregation‐Induced Emission Mechanism
Authors: Guan Jianxin , Wei Rong , Prlj Antonio , Peng Jie , Lin Kun‐Han , Liu Jitian , Han Han , Corminboeuf Clémence , Zhao Dahui , Yu Zhihao , Zheng Junrong 
Published: May 2020

AbstractThe mechanism of aggregation‐induced emission, which overcomes the common aggregation‐caused quenching problem in organic optoelectronics, is revealed by monitoring the real time structural evolution and dynamics of electronic excited state with frequency and polarization resolved ultrafast UV/IR spectroscopy and theoretical calculations. The formation of Woodward–Hoffmann cyclic intermediates upon ultraviolet excitation is observed in dilute solutions of tetraphenylethylene and its derivatives but not in their respective solid. The ultrafast cyclization provides an efficient nonradiative relaxation pathway through crossing a conical intersection. Without such a reaction mechanism, the electronic excitation is preserved in the molecular solids and the molecule fluoresces efficiently, aided by the very slow intermolecular charge and energy transfers due to the well separated molecular packing arrangement. The mechanisms can be general for tuning the properties of chromophores in different phases for various important applications.
Al2Pt für die Sauerstoffentwicklungsreaktion bei der Wasserspaltung: eine Strategie zur Erzeugung von Multifunktionalität in der Elektrokatalyse
Authors: Antonyshyn Iryna , Barrios Jiménez Ana M. , Sichevych Olga , Burkhardt Ulrich , Veremchuk Igor , Schmidt Marcus , Ormeci Alim , Spanos Ioannis , Tarasov Andrey , Teschner Detre , Algara‐Siller Gerardo , Schlögl Robert , Grin Yuri 
Published: May 2020

AbstractDie Herstellung von Wasserstoff durch Wasserelektrolyse ist nur möglich, wenn wirksame und stabile Katalysatoren für die Sauerstoffentwicklungsreaktion (Oxygen Evolution Reaction, OER) verfügbar sind. Intermetallische Verbindungen mit genau definierter Kristallstruktur und elektronischen Eigenschaften sowie besonderer chemischer Bindung werden als Vorstufe für neue Werkstoffe vorgeschlagen, die interessante katalytische Eigenschaften aufweisen. Al2Pt kristallisiert im Anti‐Fluorit‐Kristallstrukturtyp und zeigt eine stark polare chemische Bindung. Platin ist hierbei katalytisch aktiv und wird auch unter den Bedingungen der Sauerstoffentwicklungsreaktion vergleichsweise wenig aus der Katalysatoroberfläche herausgelöst. Im Folgenden wird die unerwartete Leistungsfähigkeit einer Oberflächen‐Nanokomposit‐Architektur beschrieben, die aus der selbstorganisierten Umwandlung der intermetallischen Vorstufe Al2Pt resultiert. Hierbei wird insbesondere das Langzeitverhalten der katalytischen Aktivität und Stabilität unter den Bedingungen der Sauerstoffentwicklungsreaktion untersucht.