bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic transcatheter arterial embolization for high-risk ulcers following endoscopic hemostasis: A meta-analysis
Authors: Yu Qian , Liu Chenyu , Patel Mikin , Ahmed Osman 
Published: November 2020

Abstract
Background: To conduct a meta-analysis to assess the safety and efficacy of prophylactic transcatheter arterial embolization (PTAE) for the treatment of high-risk bleeding peptic ulcers after achieving endoscopic hemostasis.Methods: PubMed and Cochrane Library were queried for full-text articles published up to December 2019. The following keywords were used: “prophylactic embolization”, “supplement embolization”, “gastrointestinal bleeding”, and “ulcer bleeding”. High-risk ulcers were defined based on endoscopic findings (i.e. large ulcers, Forrest class I-IIb) and/or clinical presentation (i.e. hypotension, decreased hemoglobin during endoscopy). Only comparative studies investigating PTAE versus conservative treatment after achieving endoscopic hemostasis were included. Baseline study characteristics, re-bleeding rate, need for surgery, mortality, and PTAE-related complication rates were investigated. Quantitative analyses were performed with STATA 15.1.Results: Among the five original studies included, a total of 265 patients received PTAE and 617 were managed conservatively after endoscopy. The rebleeding rate (6.8% vs 14.3%, p=0.003) and mortality (4.5% vs 8.8%, p=0.032) of patients from the PTAE group were lower than the control group. PTAE also reduced the cumulative need of future surgical intervention (3.0% vs 14.4%, p=0.005). The PTAE-related major and minor events were 0.75% and 14.4%, respectively. Conclusion: PTAE had therapeutic potentials in reducing rebleeding risk, need of surgical intervention, and morality in high-risk peptic ulcers after achieving endoscopic hemostasis. The embolization-associated adverse events were minimal. Future studies should aim to increase the sample size and resources for performing endovascular interventions.
Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population
Authors: Jing Li , Du Yujiao , Liu Yini , Du Jiaoyang , Zhang Ruo , Qu Pengfei , Yan Hong , Wang Duolao , Dang Shaonong 
Published: November 2020

Abstract
Background: Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring.Methods: The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in case group and 1581 in control group. The life events were assessed by Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate odds ratio and 95% confidence interval for the effects of life events on CHD.Results: With confounders adjusted, pregnant women with positive events experienced had 62% lower odds of CHD in offspring than those without (OR =0.38, 95%CI: 0.30~0.48). Those exposed to negative events were 1.64 times odds to have CHD that of those without (OR =1.64, 95%CI: 1.31~2.05). The both effects showed dose-response association. Besides, positive events could weaken the risk impact of negative events on CHD.Conclusion: It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.
A risk-prediction nomogram for patients with second-trimester threatened miscarriage associated with adverse outcomes
Authors: Li Zheng , He Ying-Dong , Chen Qian 
Published: November 2020

Abstract
Background: Both ultrasound, demographic, biochemical and laboratory markers alone have been analyzed in the previous literatures for the prediction of miscarriage; however, these independent factors have not yet been integrated for analysis. Thus, we performed this analysis to determine the best combination markers to establish a nomogram prediction model for patients presenting with second-trimester threatened miscarriage and verify its validity prospectively. Methods: We retrospectively collected information from the patients hospitalized with second-trimester threatened miscarriage and used the logistic regression analyzes to determine the most significant predictive factors associated with miscarriage. While the individualized risk-prediction nomogram model was established based on the predictors’ regression coefficients. The area under the receiver operating characteristic curves and the Hosmer-Lemeshow test were utilized to verify the discrimination and calibration of the prediction model, respectively. Results: This study demonstrates that gestational weeks, C-reactive protein, vaginal blood loss, premature rupture of membranes, and uterine adenomyosis or adenomyoma were the most significant independent risk factors of the second-trimester threatened miscarriage associated with adverse outcomes. Conclusions: We can estimate the possibility of second-trimester miscarriage through the nomogram prediction model which has good recognition and calibration.
In Silico Docking for Inhibition Neuropilin-1 (SARS-CoV-2 Receptor) by Some Natural and Approved Drugs
Authors: G.Seadawy Mohamed , Shamel Mohamed , Ahmed Aya , Zekri Abdel Rahman N. 
Published: November 2020

Abstract
Severe Acute Respiratory Syndrome Coronavirus2 (SARS-CoV-2) attached to Angiotensin Converting Enzyme 2 (ACE2) as human receptor. The Spike (S) protein of this virus is responsible for host cell penetration and attachment. This viral glycoprotein is synthesized as a precursor in infected cells and, to be active, must be cleaved to two associated polypeptides: S1 and S2 1, 2. We made Insilco docking between the spike protein and Neuropilin-1 using Cluspro 2.0 software. Therefore, Neuropilin-1 becomes host factor for SARS-CoV-2 infection. Our study revealed that some drugs and natural compounds success in inhibition of binding between the virus and its new receptor with Insilco docking data.
Predicting Survival in Patients With Acute Decompensated Heart Failure Complicated by Cardiogenic Shock
Authors: Morici Nuccia , Viola Giovanna , Antolini Laura , Martello Michela Dal , Sacco Alice , Bottiroli Maurizio , Pappalardo Federico , Villanova Luca , Ponti Laura De , Vecchia Carlo La , Frigerio Maria , Oliva Fabrizio , Fried Justin , Colombo Paolo , Garan Arthur R 
Published: November 2020

Abstract
Background: Acute decompensated heart failure (ADHF) complicated by cardiogenic shock (CS) has unique pathophysiological background requiring specific patient stratification, management and therapeutic targets. Accordingly, the aim of this study was to derive a simple stratification tool to predict survival in patients with ADHF complicated by CS. Methods and results: We analyzed data from a historic cohort of 87 ADHF-CS consecutive patients, eligible to heart replacement therapy (HRT), enrolled between 2015 and 2019. The association between selected independent variables (age, lactates and creatinine, ALC-shock score) and 28-day overall mortality was investigated through a multivariable logistic model. Predictive validity was assessed throughout an internal and external validation and compared to the Cardshock score. A nomogram was developed for predicting 28-day mortality. Overall 28-day mortality was 34%. Among patients who survived, 38 (67%) were treated with HRT: heart transplantation was performed in 68%, the remaining received an LVAD. The ALC-shock score showed better discrimination (Area Under the Curve-AUC- 0.82; 95% CI 0.73-0.91) as compared to the Cardshock score (AUC 0.67; 95% CI 0.55-0.79) (p = 0.009) to predict 28-days overall mortality. In the validation cohort the AUC for the ALC-shock score was 0.66. Conclusions: A model including age, lactates and creatinine on admission (ALC-Shock score) could be considered to predict short-term mortality in CS-ADHF patients in order to drive towards a treatment intensification. Disclosures: Dr. Garan is supported by National Institutes of Health Grant No. KL2TR001874 and has received honoraria from Abiomed. Dr. Colombo reports institutional grant support from Abbott Vascular. None of the listed entities has had any involvement with the development of the manuscript. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.Research ethics: This study was approved by the Local Ethics Committee of Milano Area 3 of the ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milano (reference number: 543-23092020).
Giant Intraparenchymal Meningioma in a Female Child: Case Report and Literature Review
Authors: Guo Huachao , Ma Zhen , Wen Shuo , Wang Yong , Wang Jiaguang , Wang Yushe 
Published: November 2020

Abstract
Background: ntraparenchymal meningiomas without dural attachment are extremely rare, especially in female children. To our knowledge, fibrous intraparenchymal meningioma located in the temporal lobe has never been reported in female children. The significance in the differential diagnosis of lesions in the temporal lobe should be emphasized.Case presentation: A 12-year-old girl was admitted to our hospital, complaining of recurrent generalized seizures for 2 months. Magnetic resonance imaging demonstrated a solid lesion located in the temporal lobe. The lesion underwent gross total resection. Histopathological examination indicated that the lesion was a fibrous meningioma. Postoperative rehabilitation was uneventful. Conclusions: This case report presents an extremely unusual intraparenchymal fibrous meningioma of the temporal lobe with peritumoral edema and reviewed 20 intraparenchymal meningioma cases in children and to discuss the clinical presentation and treatment, differential diagnosis, and radiological features.
MiR-20b-5p Targets KIF23 to Suppress Cell Proliferation and Migration in Osteosarcoma
Authors: Wang Zhongyuan , Wang Jian , Gao Yuzhong , Wang Chuanbao , Cui Yuteng , Zou Zhi 
Published: November 2020

Abstract
Background: MicroRNAs (miRNAs) are closely correlated with the development of cancer. Here, the main goal of this study was to analyze the biological function of miR-20b-5p in osteosarcoma (OS). Methods: The expression of miR-20b-5p and kinesin family member 23 (KIF23) was determined using quantitative real time PCR and western blot analysis, respectively. The correlation between miR-20b-5p or KIF23 expression and the clinicopathological characteristics of OS was evaluated using Chi-square test. Functional experiments, including CCK-8, flow cytometry and transwell assay were performed to analyze cell proliferation, cell cycle distribution and apoptosis, and migration. The association between miR-20b-5p and KIF23 was confirmed by luciferase reporter assay.Results: Firstly, we observed that miR-20b-5p expression was significantly decreased, while kinesin family member 23 (KIF23) expression was increased in OS tissues. Moreover, miR-20b-5p expression was inversely correlated with KIF23 expression in OS tissues. Clinically, decreased miR-20b-5p expression was significantly associated with increased metastasis and increased KIF23 mRNA expression level was remarkedly correlated with increased tumor size. Overexpression of miR-20b-5p significantly suppressed cell proliferation and migration, as well as caused G0/G1 phase arrest and apoptosis in OS cells (U2OS and MG-63). Mechanistically, miR-20b-5p directly targeted to the 3’-UTR of KIF23 and negatively regulated its expression in OS cells. Moreover, KIF23 knockdown imitated, while overexpression abolished the effects on U2OS cell proliferation, G1/S transition, apoptosis and migration induced by miR-20b-5p overexpression. Furthermore, KIF23 overexpression reversed the miR-20b-5p-induced downregulation of CDK4, Cyclin D1, Bcl-2, PCNA, Ki-67 and N-cadherin, as well as upregulation of Bad and E-cadherin in U2OS cells.Conclusions: In conclusion, miR-20b-5p directly targeted the 3'UTR of KIF23 mRNA to inhibit the proliferation and migration of human OS cells in vitro, which might be a promising candidate target for OS treatment.
CircRNA CircRIMS is Overexpressed in Esophageal&nbsp;Squamous Cell Carcinoma and Downregulate miR-613 through Methylation to Increase Cell Proliferation
Authors: Wan Haijun , Yuan Bosi , Jiang Kang , Wei Juan , Feng Xiaoyue , Sun Bo , Wang Fangyu 
Published: November 2020

Abstract
BackgroundEsophageal squamous cell carcinoma (ESCC) as the most common subtype of esophageal cancer accounts for about 95% of all cases. CircRNA CircRIMS has been characterized as an oncogenic circRNA in gastric cancer, while its role in other cancers is unknown. This study aimed to explore the role of CircRIMS in esophageal squamous cell carcinoma (ESCC). MethodsTissues collected from 60 ESCC patients were used in this study. The expression of CircRIMS and miR-613 were detected by RT-qPCRs. The 60 ESCC patients were followed up for 5 years to evaluate the prognostic value of CircRIMS for ESCC. The role of CircRIMS in regulating the expression of miR-613 and methylation was assess by overexpression experiments and RT-qPCRs. The role of CircRIMS and miR-613 in regulating cell proliferation was analyzed by BrdU assay. ResultsWe found that CircRIMS was overexpressed in ESCC and predicted poor survival. In addition, miR-613 was downregulated in ESCC and inversely correlated with CircRIMS. In ESCC cells, overexpression of CircRIMS decreased the expression levels of miR-613 and increased the methylation of miR-613 gene. Cell proliferation assay showed that overexpression of CircRIMS reduced the inhibitory effects of overexpression of miR-613 on cell proliferation. Conclusions﻿CircRIMS may downregulate miR-613 through methylation to increase cell proliferation in ESCC.
Validation of Mini-Mental Adjustment to Cancer Scale in A Moroccan Sample of Breast Cancer Women
Authors: RAGALA Mohammed El Amine , HILALY Jaouad El , AMAADOUR Lamiae , OMARI Majid , ASRI Achraf El , ATASSI Mariam , BENBRAHIM Zineb , MELLAS Naoufal , rhazi Karima El , HALIM Karima , ZARROUQ Btissame 
Published: November 2020

Abstract
Background: The Mini-Mental Adjustment to Cancer Scale (Mini-MAC) instrument is commonly used worldwide by professionals of oncology, but the scale has not, up to date, been validated in Arabic and Moroccan context, and there is absence of data in the Moroccan population. This study aims to validate the Mini-MAC, translated and adapted to the Arabic language and Moroccan culture, in women with breast cancer.Methods: The Mini-MAC instrument was administered to 203 breast cancer women, receiving medical care in the university Hospital of Fez city. A cross-sectional validation study using exploratory factor analysis and Confirmatory factor analysis was carried out.Results: Confirmatory factor analysis confirmed Watson’s original structure underlying the Mini-MAC items: Helpless/Hopeless, Anxious Preoccupation, Fighting Spirit, Cognitive Avoidance, and Fatalism. Absolute, incremental, and parsinmonious fit indices showed a high significant level of acceptance confirming a good performance of the measurement model. The instrument showed sufficient reliability and convergent validity demonstrated by acceptable values of composite reliability (CR =0.93–0.97), and average variance extracted (AVE= 0.66 - 0.93), respectively. The square roots of AVE were higher than factor-factor pairs correlations, and the Heterotrait-Monotrait ratio of correlations values were lesser than 0.85, indicating an acceptable discriminant validity. Conclusions: reliability; and both convergent and discriminant validity tests indicated that The Arabic version of the Mini-MAC had a good performance and may serve as a valid tool measuring psychological responses to cancer diagnosis and treatment.
Prophylactic heparin and risk of&nbsp;orotracheal intubation&nbsp;or death in patients with mild or moderate COVID-19 pneumonia
Authors: Vergori Alessandra , Lorenzini Patrizia , Lepri Alessandro Cozzi , Donno Davide Roberto , Gualano Gina , Nicastri Emanuele , Iacomi Fabio , Marchioni Luisa , Campioni Paolo , Schininà Vincenzo , Cicalini Stefania , Agrati Chiara , Capobianchi Maria Rosaria , Girardi Enrico , Ippolito Giuseppe , Vaia Francesco , Petrosillo Nicola , Antinori Andrea , Taglietti Fabrizio 
Published: November 2020

Abstract
Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia.Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50-77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95%CI 3.2-26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7-15.9) in those exposed to pLMWH;p-value=0.144. This risk associated with the use of pLMWH appeared to vary by PaO2/FiO2 ratio: aHR 1.40 (95%CI 0.51-3.79) for patients with an admission PaO2/FiO2 < 300 mmHg and 0.27 (0.03-2.18) for those with PaO2/FiO2 >300 mmHg;p-value at interaction test 0.16. pLMWH does not seem to reduce the risk of OTI/death mild/moderate COVID-19 pneumonia, especially when respiratory function had already significantly deteriorated. Data from clinical trials comparing the effect of prophylactic vs. therapeutic dosage of LMWH at various stages of COVID-19 disease are needed.
Prevalence and associated risk factors for childhood strabismus in Lhasa, Tibet, China: a cross-sectional, school-based study
Authors: He Hailong , Fu Jing , Meng Zhaojun , Chen Weiwei , Li Lei , Zhao Xinyu 
Published: November 2020

Abstract
Background: To estimate the prevalence of strabismus and associated risk factors among grade one school children in Lhasa, Tibet, China. Methods: The Lhasa Childhood Eye Study (LCES) was a cross-sectional, school-based childhood study conducted in Grade one students from primary schools in Lhasa, Tibet, China. Comprehensive ophthalmic examinations and basic systematic examinations were evaluated. A questionnaire survey contained information about children, as well as parents’ information was sent to the corresponding parents of eligible children. The prevalence of strabismus and its 95% confidence interval was estimated. Univariate and multivariate logistic regression analyses were conducted to determine the associated risk factors. Results: A total of 1942 eligible grade one students were enrolled, of which 1856 participants completed all procedures. The average age was 6.83±0.46 years, 53% of participants were boys and 1762 were the Tibetan Minority. Over all, the prevalence of strabismus was 68/1856(3.7%) (95%CI: 2.81,4.52), with no difference between the ages, genders, ethnics and BMI, while tilt one's head when writing may be a risk factor for strabismus ( P =0.004). Strabismus students had the mean best corrected visual acuity 0.16±0.28(LogMAR), over 50% patients with esotropia are hyperopia, participants who have stereopsis impairments showed a significant difference between esotropia and exotropia ( P= 0.026). Conclusions: The prevalence of strabismus in LCES was 3.7%, higher than previous reports from Chinese childhood epidemiology studies. Strabismus is a common contributing factor to amblyopia. Tilt one's head when writing may be a risk factor. Patients with esotropia are more likely to affect stereopsis and be the refractive state of hyperopia.
Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients
Authors: Ma Jing , Ai xiaofei , Wang Jinhuan , Xing Limin , Tian Chen , Yang Hongliang , Yu Yong , Zhao Haifeng , Wang Xiaofang , Zhao Zhigang , Wang Yafei , Cao Zeng 
Published: November 2020

Abstract
Background Chromosomal abnormalities play an important role in classification and prognostication of myelodysplastic syndromes (MDS) patients. However, more than 50% low risk MDS patients harbor a normal karyotype. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for the detection of cytogenetic aberrations in MDS patients. Methods To characterize the subset of MDS with normal karyotype or failed chromosome banding analysis, we analyzed 144 patient samples with normal karyotype or undetectable through regular chromosome banding, which were subjected to parallel comparison via fluorescence in situ hybridization (FISH) and MLPA. Results MLPA identifies copy number changes in 16.7% of 144 MDS patients and we observed a significant difference in overall survival (OS) (median OS: undefined vs 27 months, p=0.0071) in patients with normal karyotype proved by MLPA, versus aberrant karyotype cohort as determined by MLPA. Interestingly, patients with undetectable karyotype via regular chromosome banding indicated inferior outcome. Conclusion Collectively, MDS patients with normal or undetectable karyotype via chromosome banding analysis can be further clarified by MLPA, providing more prognostic information that benefit for individualized therapy.
End-stage knee osteoarthritis with and without sarcopenia and the effect of knee arthroplasty – a prospective cohort study
Authors: Ho Kevin Ki-Wai , Lau Lawrence Chun-Man , Chau Wai Wang , Poon Queena , Chung Kwong-Yin , Wong Ronald Man-Yeung 
Published: November 2020

Abstract
Background:Sarcopenia often accompanies osteoarthritis (OA), which is managed by total knee arthroplasty (TKA) in the late stage. Recent studies have suggested a higher risk of post-operative complications after TKA in sarcopenic OA subjects, but whether TKA can benefit them similar to non-sarcopenic subjects remains unexplored. This study aimed to examine the dynamic, mutual impact of sarcopenia and TKA in a one-year post-operative period.Methods: This prospective cohort study was conducted between 2015 to 2018 at our hospital. Patients with end-stage OA of the knee waiting for TKA were recruited into the study. Primary outcome measures were change in muscle strength, mass and function. Secondary outcome measures were quality of life (QOL) measurements for pain, psychological and physical health.Results: Fifty-eight patients were recruited, of which 79.3% were female and 32.8% already had sarcopenia at baseline. The average age of sarcopenic subjects and non-sarcopenic subjects was comparable (67.89±7.07 vs. 67.92±6.85; p=0.99), but sarcopenic subjects had a lower body mass index (BMI) (25.64±2.64 vs. 28.57±4.04; p=0.01). There was a statistically significant improvement in walking speed (10.24±5.35 vs. 7.69±2.68, p<0.01) and muscle strength in both sarcopenic and non-sarcopenic patients after TKA. This was accompanied by an improvement trend in muscle mass in all subjects. There was no change in handgrip power before and after TKA and subsequent follow-up (19.31±5.92 vs. 18.98±6.37 vs. 19.36±7.66; p=0.97). QOL measured before, after and at follow-up with WOMAC (total: 42.27±15.98 vs. 20.65±15.24 vs. 16.65±18.13) and SF12v2 (PCS: 33.06±8.55 vs. 38.96±8.01 vs. 40.67±7.93) revealed progressive significant improvement (both comparisons p≤0.01). Further analysis with the IPAQ also found increased engagement of high-intensity activities.Conclusions: This study showed that sarcopenia among patients with end-stage OA of the knee is not uncommon, but both sarcopenic and non-sarcopenic OA patients achieved significant clinical and functional improvement after TKA. Further studies with an larger sample size and different ethnicities could help ascertain a beneficial role of TKA in sarcopenic OA subjects.