bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvements in the degree of understanding the treatment guidelines for schizophrenia and major depressive disorder in a nationwide dissemination and implementation study
Authors: Numata Shusuke , Nakataki Masahito , Hasegawa Naomi , Takaesu Yoshikazu , Takeshima Masahiro , Onitsuka Toshiaki , Nakamura Toshinori , Edagawa Reon , Edo Hiroaki , Miura Kenichiro , Matsumoto Junya , Yasui-Furukori Norio , Kishimoto Taishiro , Hori Hikaru , Tsuboi Takashi , Yasuda Yuka , Furihata Ryuji , Muraoka Hiroyuki , Ochi Shinichiro , Nagasawa Tatsuya , Kyou Yoshitaka , Murata Atsunobu , Katsumoto Eiichi , Ohi Kazutaka , Hishimoto Akitoyo , Inada Ken , Watanabe Koichiro , Hashimoto Ryota 
Published: November 2020

Abstract
Background: To implement clinical practice guidelines (CPGs), it is necessary for psychiatrists to deepen their understanding of existing CPGs. The Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project is a nationwide dissemination and implementation study of two sets of CPGs, including one for schizophrenia and one for major depressive disorder (MDD).Methods: A total of 413 psychiatrists (n=212 in 2016; n=201 in 2017) learned the two CPGs in the education program of the EGUIDE project over two days, and clinical knowledge of the two CPGs was evaluated by two 37-item questionnaires at baseline and after the EGUIDE programs. To improve the correct answer rate for clinical knowledge after the EGUIDE programs, we revised the lecture materials associated with items that had a low correct answer rate in 2016 and used the revised lecture materials with the CPGs in 2017. The rates of correct answers for each item after the EGUIDE programs were compared between the 2016 and 2017 groups.Results: The total clinical knowledge scores significantly increased after the EGUIDE program in both the 2016 groups and the 2017 groups. We revised lecture materials related to two items in the schizophrenia CPG and five items in the MDD CPG that had low correct answer rates after the EGUIDE programs. The correct answer rate of one item on the schizophrenia CPG and one item on the MDD CPG were increased (S-D5, p=0.038; D-C6, p=0.033) and that of one item on the MDD CPG was significantly improved (D-D3, p=0.00080) in the 2017 group compared to the rates of the 2016 group. The correct response rates of the other four items were not significantly improved.Conclusions: We reported improvements in clinical knowledge of CPGs after the EGUIDE program in the 2017 group following revisions of the lecture materials based on the results from the 2016 group. These attempts to improve the degree of understanding of CPGs may facilitate the successful dissemination and implementation of psychiatric guidelines in everyday practice.Trial registration: Effectiveness of Guideline for Dissemination and Education in Psychiatric Treatment, UMIN000022645, Registered 15 June 2016, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000026044&type=summary&language=J
Oncogenic 3D genome conformations identify novel therapeutic targets in ependymoma
Authors: Okonechnikov Konstantin , Camgoz Aylin , Park Donglim Esther , Chapman Owen , Hübner Jens-Martin , Chakraborty Abhijit , Pagadala Meghana , Bump Rosalind , Chandran Sahaana , Kraft Katerina , Acuna-Hidalgo Rocio , Reid Derek , Juarez Edwin F. , Robinson James T. , Pajtler Kristian W. , Mauermann Monika , Milde Till , Coufal Nicole G. , Levy Michael , Malicki Denise , Nahas Shareef , Snuderl Matija , Crawford John , Wechsler-Reya Robert J. , Mundlos Stefan , Schmitt Anthony , Carter Hannah , Michaelraj Kulandaimanuvel Antony , Kumar Sachin A. , Taylor Michael D. , Rich Jeremy , Buchholz Frank , Mesirov Jill P. , Pfister Stefan M. , Ay Ferhat , Dixon Jesse R. , Kool Marcel , Chavez Lukas 
Published: November 2020

Abstract
Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial RELA-fusion associated group and the posterior fossa ependymoma group A. In both groups, tumors occur mainly in young children and frequently recur after treatment1. Although the molecular mechanisms underlying these diseases have recently been uncovered, they remain difficult to target and innovative therapeutic approaches are urgently needed. Here, we use genome-wide chromosome conformation capture (Hi-C), complemented with CTCF (insulators) and H3K27ac (active enhancers) ChIP-seq as well as gene expression and whole-genome DNA methylation profiling in primary and relapsed ependymoma tumors and cell lines to identify chromosomal rearrangements and regulatory mechanisms underlying aberrant expression of genes that are essential for ependymoma tumorigenesis. In particular, we observe the formation of new topologically associating domains (‘neo-TADs’) by intra- and inter-chromosomal structural variants, tumor-specific 3D chromatin complexes of regulatory elements, and the replacement of CTCF insulators by DNA hyper-methylation as novel oncogenic mechanisms in ependymoma. Through inhibition experiments we validated that the newly identified genes, including RCOR2, ITGA6, LAMC1, and ARL4C, are highly essential for the survival of patient-derived ependymoma models in a disease subtype-specific manner. Thus, this study identifies potential novel therapeutic vulnerabilities in ependymoma and extends our ability to reveal tumor-dependency genes and pathways by oncogenic 3D genome conformations even in tumors that lack known genetic alterations.
Incidental Findings on Whole-body Computed Tomography in Major Trauma Patients: Who and What?
Authors: Liu Ping-Yuan , Kuo Ling-Wei , Liao Chien-Hung , Hsieh Chi-Hsun , Bajani Francesco , Fu Chih-Yuan 
Published: November 2020

Abstract
Background The use of whole-body computed tomography (WBCT) scans has greatly increased in the management of patients with major trauma. Sometimes, nontraumatic findings on WBCT are observed. In the current study, we aimed to investigate the proportion of nontraumatic findings on WBCT in major trauma patients and the characteristics of patients with nontraumatic findings on WBCT.Methods From June 2013 to May 2016, adult trauma patients who received WBCT were enrolled. The proportions of nontraumatic findings in different anatomical regions were studied. Nontraumatic findings were classified and evaluated as clinically important findings and findings that did not need further follow-up or treatment. The characteristics of patients with nontraumatic findings were analyzed and compared with those of patients without nontraumatic findings.Results A total of 217 patients were enrolled in this study during the 3-year study period, and 89 (41.0%) patients had nontraumatic findings. Nontraumatic findings were found more frequently in the abdomen (69.2%) than in the head/neck (17.3%) and chest regions (13.5%). In total, 31.3% of the findings needed further follow-up or treatment. Patients with nontraumatic findings that needed further management were significantly older than patients without nontraumatic findings (57.3 vs. 38.9, p<0.001), especially those with abdominal nontraumatic findings (57.9 vs. 41.3, p<0.001). A significantly higher proportion of females was observed in the group with head/neck nontraumatic findings that needed further management than in the group without nontraumatic findings (56.3% vs. 24.9%, p=0.015).Conclusions WBCT could provide alternative benefits for nontraumatic findings. The WBCT images should be read carefully for nontraumatic findings, especially for elderly patients. For female patients, the head/neck region should be carefully evaluated with WBCT for possible thyroid lesions. A comprehensive program for the follow-up of nontraumatic findings is needed.
Hyperbolic Metamaterials via Hierarchical Block Copolymer Nanostructures
Authors: Murataj Irdi , Channab Marwan , Cara Eleonora , Pirri Candido Fabrizio , Boarino Luca , Angelini Angelo , Lupi Federico Ferrarese 
Published: November 2020

Abstract
Hyperbolic metamaterials (HMMs) offer unconventional properties in the field of optics, enabling the opportunity for confinement and propagation of light at the nanoscale. In-plane orientation of the optical axis, in the direction coinciding with the anisotropy of the HMMs, is desirable for a variety of novel applications in nanophotonics and imaging. Here, we introduce a method for creating localized HMMs with in-plane optical axis based on block copolymers (BCPs) blend instability. The dewetting of BCP thin film over topographically defined substrates generates droplets composed of highly ordered lamellar nanostructures in hierarchical configuration. The hierarchical nanostructures represent a valuable platform for the subsequent pattern transfer into a Au/air HMM, exhibiting hyperbolic behavior in a broad wavelength range in the visible spectrum. A computed Purcell factor as high as 32 at 580 nm supports the strong reduction in the fluorescence lifetime of defects in nanodiamonds placed on top of the HMM.
Assessing the Quality of Reporting to China's National TB Surveillance Systems
Authors: Li Tao , YANG Lijia , SMITH-JEFFCOAT Sarah E. , WANG Alice , GUO Hui , CHEN Wei , DU Xin , ZHANG Hui 
Published: November 2020

Abstract
Background: The reliability of disease surveillance may be restricted by sensitivity or the ability of the system to capture all disease. Our objective was to quantify under-reporting and concordance of recording persons with tuberculosis (TB) in the national TB surveillance systems: Infectious Disease Reporting System (IDRS) and TB Information Management System (TBIMS). Methods: This retrospective review includes patients identified in 2016 from six counties in Guangdong, Jiangsu, Henan, Heilongjiang, Sichuan, and Yunnan provinces. County staff linked TB patients identified from facility-specific health and laboratory information systems with TB patients recorded in IDRS and TBIMS. Under-reporting was calculated as the percentage of TB patients not recorded in IDRS or TBIMS. Timeliness, patients recorded within 24 hours after diagnosis, and concordance, accuracy and completeness of key variables when compared to medical records, were analyzed through comparing sampled patient-records with corresponding patient-records in health facilities. Multivariable logistic regression was used to examine factors associated with under-reporting. Results: We found 505 (10.7%) patients diagnosed with TB were missing within IDRS and 1451 (30.9%) patients were missing within TBIMS. Of 171 patient-records reviewed in IDRS and 170 patient-records in TBIMS, 12.3% and 6.5% were found to be untimely, 10.7% and 7.1% were found having inconsistent home address. The risk of under-reporting to both IDRS and TBIMS was greatest in TB diagnosis at a tertiary health facilities and non-residents; the risk of under-reporting to TBIMS was greatest with patients aged 65 or older and extrapulmonary TB (EPTB).Conclusions: We found that more than one in four TB patients were not recorded in TBIMS. It is important to improve the reporting and recording of TB patients. Local TB programs that focus on training, and mentoring high-burden hospitals, facilities that cater to EPTB, and migrant patients may improve reporting and recording. Additional human resources for data collection and management, and monitoring and evaluation systems are needed to improve national surveillance systems and TB prevention, diagnosis and treatment services.
Forecasting the Carsharing Service Demand Using Uni and Multivariable Models
Authors: Alencar Victor Aquiles , Pessamilio Lucas Ribeiro , Silva Felipe Rooke da , Bernardino Heder Soares , Vieira Alex Borges 
Published: November 2020

Abstract
Car-sharing is an alternative to urban mobility that has been widely adopted. However, this approach is prone to several problems, such as fleet imbalance, due to the variance of the daily demand in large urban centers. In this work, we apply two time series techniques, namely, Long Short-Term Memory (LSTM) and Prophet, to infer the demand for three real car-sharing services. We also apply several state-of-the-art models on free-floating data in order to get a better understanding of what works best for this type of data. In addition to historical data, we also use climatic attributes in LSTM applications. As a result, the addition of meteorological data improved the model’s performance, especially on Evo: an average Mean Absolute Error (MAE) of approximately 61.13 travels was obtained with the demand data on Evo, while MAE equals 32.72 travels was observed when adding the climatic data, the other datasets also improved but none other improved this much. For the free-floating data test, we got the Boosting Algorithms (XGBoost, Catboost, and LightGBM) got the best performance short term, the worst one has an improvement of around 22% of MAE over the next best-ranked (Prophet). Meanwhile in the long term Prophet got the best MAE result, around 22.5% better than the second-best (LSTM).
Real space-time imaging of valence electron motion in molecules
Authors: Garg Manish , Martin-Jimenez Alberto , Pisarra Michele , Martín Fernando , Kern Klaus 
Published: November 2020

Abstract
Tracking valence electron motion in molecules is the key to understand and control chemical transformations. Contemporary techniques in attosecond science have the capability to generate and track the consequences of this motion in real time, but not in real space. Consequently, the local time-evolution of the electron density can so far only be inferred by reconstruction from the (often elusive) features appearing in electron, ion, absorption or emission spectra, mainly in small molecules. Scanning tunnelling microscopy (STM), on the other hand, can locally probe the valence electron density in molecules, but cannot provide by itself dynamical information at this ultrafast time scale. Here, we demonstrate that, by combining STM and attosecond technologies, the dynamics of a coherent superposition of valence electronic states generated by < 6 femtosecond long carrier-envelope-phase (CEP) stable laser pulses can be directly and simultaneously visualized with picometer spatial resolution and 300 attosecond temporal resolution, thus going well beyond the previously established space-time limits and bypassing any kind of reconstruction. In particular, we show that near fields of near-infrared pulses confined to the apex of a nanotip of an STM enable concurrent real-space and real-time imaging of the valence electron dynamics generated in the perylenetetracarboxylic dianhydride (PTCDA) molecule, as well as exerting full control of the electron density in the highest occupied (HOMO) and lowest unoccupied (LUMO) molecular orbitals. We envision that this approach could thus open the way to the unambiguous observation and manipulation of electron dynamics in complex molecular systems, in monolayer thick 2D materials and in superconductors.
APTIDÃO FÍSICA EM FUNÇÃO DO RISCO CARDIOVASCULAR POR MEIO DA RELAÇÃO CINTURA ESTATURA DE SEDENTÁRIOS
Authors: Do Nascimento Reginaldo Luiz , Do Nascimento Junior José Roberto Andrade , Saraiva Layane Costa , Dos Santos Lélio Ferreira , Carneiro Marcus Vinicius Oliveira , Araujo Flavio de Sousa , Carvalho Ferdinando Oliveira 
Published: November 2020

O objetivo do estudo foi comparar a aptidão física de indivíduos sedentários da cidade de Petrolina-PE em função do sexo, faixa etária e risco cardiovascular por meio da relação cintura estatura. A amostra foi composta por 3.173 indivíduos de ambos os sexos, considerados sedentários e com faixa etária entre 18 a 64 anos. Foram coletadas massa corporal, estatura, circunferência da cintura e do quadril, dobras cutâneas, testes motores (flexibilidade, flexão de cotovelo e flexão de tronco), pressão arterial sistólica e diastólica e frequência cardíaca de repouso, e posteriormente calculada relação cintura quadril e cintura estatura e pressão arterial média, e foi estimado o volume máximo de oxigênio. Para a análise dos dados, foram utilizados os testes “U” de Mann-Whitney e Kruskal-Wallis, sendo adotada uma de significância de p<0,05. Os resultados evidenciaram que houve diferenças significativas (p < 0,05) em todas as medidas avaliadas em relação ao sexo de indivíduos sedentários. Os resultados foram significativos quando comparado às faixas etárias dos sexos masculino e feminino para todas as variáveis dentro dos percentis 25, 50 e 75, e também quando comparado os grupos de menor e maior risco cardiovascular. Concluiu-se que participantes homens possuem melhor aptidão física que as mulheres, sendo que esta tende a piorar com o avançar da idade para ambos os sexos, além do que os sujeitos classificados com maior risco cardiovascular apresentaram pior aptidão física.
Local coordinate weight reconstruction for rolling bearing fault diagnosis
Authors: Wu Chenxi , Jiang Rong , Huang Zhonghua , Wu Xin , Liu Zhe 
Published: November 2020

The high dimensionality data originating from rolling bearing measuring signals with non-linearity and low signal to noise ratio often contains too much disturbance like interference and redundancy for accurate condition identification. A novel manifold learning named Local coordinate weight reconstruction (LCWR) is proposed to remove such disturbance. Due to the different contribution of samples to their manifold structure, weight value is used for the contribution difference. By reconstructing local low-dimensional coordinates according to its weight function about geodesic distance in neighborhood, LCWR targets to reduce reconstruction error, preserve intrinsic structure of the high dimensionality data, eradicate disturbance and extract sensitive features as global low-dimensional coordinates. The experimental results show that the intraclass aggregation and interclass differences of global low-dimensional coordinates extracted via LCWR are better than those of local tangent space alignment (LTSA), locally linear embedding (LLE) and principal component analysis (PCA). The accuracy reaches the highest 96.43 % using SVM to identify LCWR based global low-dimensional coordinates, and its effectiveness is testified in diagnosis of rolling bearing fault.
Efficiency and viability of drip method of irrigation in groundnut cultivation: an empirical analysis from South India
Authors: Narayanamoorthy A. , Devika N. , Suresh R. , Sujitha K. S. 
Published: November 2020

Abstract
Drip method of irrigation (DMI) has the potential to save substantial water and electrical energy as well as increase the productivity of crops. Studies conducted on different high value crops have confirmed the various benefits of DMI. However, not many studies have researched the income and resource impact of drip irrigation including its benefit–cost pattern using survey data in crops like groundnut, which is an important oilseed crop in India. In this paper, an attempt has been made to fill this gap by using survey data collected from a water-scarce district from Tamil Nadu State in India. The results show that DMI can save about 34% of cultivation cost, 36% of water and electrical energy and increase about 79% of productivity over the same crop cultivated under conventional flood method of irrigation. The drip adopters are also able to generate an additional farm business income of Rs 25,911/acre (1 USD = INR 74.92, 1 acre = 4,047 m2) over the non-drip adopters. The net present worth and benefit–cost ratio estimated using discounted cash flow technique shows that investment in drip irrigation is economically highly viable for groundnut cultivating farmers.
Examining the Interaction of Extroversion and Network Structure in the Formation of Effective Informal Support Networks
Authors: Zell Deone , McGrath Cathleen , Vance Charles M. 
Published: November 2020

This study on informal support networks bridges the traditionally disparate disciplines of personality theory and social network theory, and examines the impact of extroversion on the structure of support networks, as well as the relative contribution of network structure versus extroversion to a critical element of network effectiveness: trust. Two uestionnaires measuring extroversion and social support network characteristics were administered to 113 university business students. Although no impact of extroversion was found on certain dimensions of network structure (e.g., size, diversity, behavioral aspects of strength of ties), introverts and extroverts differed in terms of affective aspects of strength of ties and embeddedness. Furthermore, although we failed to find a significant interaction effect of extroversion and embeddedness on trust, both extroversion and strength of ties predicted trust. In addition, extroverts’ networks were characterized by higher levels of intimacy and trust, which may
Calidad del cuidado y acreditación en centros de hemodiálisis
Authors: Guerra-Guerrero Veronica 
Published: November 2020

La enfermedad renal crónica terminal es actualmente considerada un problema de salud pública en el ámbito mundial, por su prevalencia e incidencia creciente en la población, su importancia relativa en la cargade enfermedad del país, su comportamiento crónico o per anente y el requerimiento de una alta complejidad técnica para su manejo (1), en donde enfermería asume un rol fundamental en el cuidado que recibe la población que tiene esta condición. Por lo tanto, la alta complejidad técnica que engloba su tratamiento, es un desafío constante para los cuidados que se otorgan particularmente a los usuarios que se encuentran en la modalidad de hemodiálisis. La enfermedad y tratamiento generan un alto impacto socioeconómico, por lo que también limita o pone en riesgo la vida y calidad de vida de las personas que la padecen, ade más de afectar el contexto directo que rodea a las personas, como lo es su familia (2).
Vascular Access Care in Patients with Multimorbidity
Authors: Armenteros-Yeguas Victoria , Tomás-López Maria Aranzazu , Miranda-Serrano Erika , Moraza-Dulanto Inmaculada , Meléndez-Fernández Lara , Merino-Romero Eva , Cristóbal-Domínguez Estíbaliz , Gárate-Echenique Lucía 
Published: November 2020

Highlights
Multimorbid patients with DIVA required more catheters than those without DIVA. The DIVA group required devices of smaller calibre and more insertion attempts. Catheter dwell time was similar but adverse events rate was higher in DIVA group. Nearly 20% of catheters were inadequate for the therapy prescribed in all patients. The results evidenced the need to improve adherence to clinical practice guidelines.
OROPHARINGEAL EXERCISE UNTUK MEMPERBAIKI JALAN NAFAS AKIBAT OBSTRUCTIVE SLEEP APNEA SYNDROM PADA KONDISI STROKE
Authors: Pertiwi Aniesa Nur Laily , Rajbiana Nada , Hayati Rida 
Published: November 2020

ABSTRAKObstructive Sleep Apnea Syndrome (OSAS) merupakan faktor resiko terjadinya stroke berulang hingga kematian. OSAS adalah sindrom obstruksi total atau parsial jalan napas yang menyebabkan gangguan nafas saat tidur. Peningkatan derajat OSAS berhubungan dengan peningkatan kematian. Oleh karena itu OSAS harus diberikan pengananan yang tepat. Penelitian menunjukkan Oropharingeal Exercise dipercaya dapat memperbaiki jalan nafas akibat OSAS pada kondisi stroke. Orofarigeal Exercise merupakan metode alternatif pada pasien stroke yang menderita OSAS dengan melakukan latihan isotonic dan isometric saluran nafas bagian atas untuk meningkatkan mobilitas dan tonisitas otot-otot pernafasan bagian atas sehingga membuka jalan nafas dan meningkatkan fungsi serta kinerja saluran pernapasan. Oleh karena itu Oropharingeal Exercise dapat digunakan sebagai terapi alternatif untuk memperbaiki jalan nafas akibat OSAS pada kondisi stroke.