bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holistic model of the formation of requirements for freight cars on the example of the “Northern Latitudinal Railway” project
Authors: Petrov S. V. , Nazarov I. V. , Nazarov O. N. 
Published: November 2020

In the context of economic integration, an important factor is increasing the efficiency of rail transport. It depends both on the quality of the transportation process as a whole and on the quality of its individual elements. It is especially worth highlighting the rolling stock, and in particular freight cars, since it is with the car along the route that labor-intensive technological operations are performed, including shunting, technical and commercial maintenance, unscheduled repairs, as well as starting and finishing operations — loading and unloading. Therefore, the efficiency of freight transportation does not depend to a small extent on the quality of cars.In this regard, the article highlights the results of the development of a holistic model for the formation of requirements for freight cars that increase the efficiency of the transportation process, taking into account the features of specific transportation conditions. In this case, a holistic model is applied to the conditions for the export of freights from fields in Western Siberia along the routes of the Northern Latitudinal Railway project.A holistic model for the formation of requirements for the cars of the Northern Latitudinal Railway includes:• operational and functional model, containing the substantiation of the technical and economic parameters of the cars and the model of their operation ranges, taking into account the technological operations performed;• reliability model containing justification of the reliability indicators of cars and the parameters of the system of their maintenance and repair;• model for evaluating and confirming efficiency based on the results of calculating a complex of technical and economic indicators of cars.The holistic model makes it possible to formulate rational requirements for cars of different levels of specialization for specific operating conditions. The model also makes it possible to predict the effects of participants in the transportation process when using cars with given characteristics in specific transportation conditions. This contributes to the use of the principles of dynamic pricing of tariffs, depending not only on the type of freight and the region, but also on the route, distance of transportation and other parameters. As a result, the advantages and competitiveness of rail transport will be provided.
Kajian reflektif: Relevansi pendidikan humanis-religius dalam menghadapi era revolusi industri 4.0
Authors: Isnaini Rohmatun Lukluk 
Published: November 2020

Penelitian ini bertujuan untuk mengkaji pendidikan humanis-religius secara reflektif dalam menghadapi era revolusi industri 4.0. Data dikumpulkan dengan teknik library research (penelitian pustaka). Data yang telah terkumpul kemudian dianalisis secara kualitatif dengan pendekatan deskriptif. Analisis data dilakukan melalui pemaparan suatu pemikiran, pendapat para ahli (Ki Hajar Dewantara dan Prof. Abdurrahman Mas’ud, Ph.D.) atau fenomena yang ada dalam kehidupan masyarakat. Hasilnya menyebutkan bahwa pendidikan humanis-religius akan terus relevan dengan berbagai perubahan zaman, terutama dalam menghadapi era revolusi industri 4.0. Hal ini dikarenakan pendidikan humanis-religius merupakan dasar pondasi dalam kehidupan setiap insan untuk menjadikannya manusia yang berkarakter baik, tidak hanya untuk dirinya sendiri tetapi juga mampu bersikap humanis terhadap sesama dengan landasan agama. Sikap humanis dan religius akan dibutuhkan pada setiap masa oleh manusia, oleh karenanya melalui pendidikan humanis-religius akan ada keseimbangan antara kemajuan intelektual untuk sosial kemasyarakatan, sehingga dapat menghasilkan generasi-generasi yang berkarakter kuat secara humanis dan religius dengan segala potensi yang dimilikinya dan diorientasikan untuk kemashlahatan umat untuk meraih kebahagiaan bagi kehidupan AbstractThis research aims to examine reflective humanist-religious education in the face of the industrial revolution era 4.0. Data collected by library research techniques (library research). The collected data is then analyzed qualitatively using a descriptive approach. Data analysis is carried out through the presentation of thought, opinion of experts (Ki Hajar Dewantara and Prof. Abdurrahman Mas'ud, Ph.D.) or phenomena that exist in people's lives. The results state that humanist-religious education will continue to be relevant to the changing times, especially in the face of the industrial revolution 4.0. This is because humanist-religious education is the basic foundation in the life of every human being to make him a human with good character not only for himself but also able to be humane towards others with a religious foundation. Humanist and religious attitudes will be needed at all times by humans. Therefore, through humanist-religious education, there will be a balance between intellectual progress for social society so that it can produce generations of people who have strong human and religious characteristics with all the potential they have and are oriented to the benefit of the people to achieve happiness for life.
A Mindfulness-Based Brain-Computer Interface to Augment Mandala Coloring for Depression: Protocol for a Single-Case Experimental Design
Authors: Daudén Roquet Claudia , Sas Corina 
Published: November 2020

Background
The regular practice of mindfulness has been shown to provide benefits for mental well-being and prevent depression relapse. Technology-mediated interventions can facilitate the uptake and sustained practice of mindfulness, yet the evaluation of interactive systems, such as brain-computer interfaces, has been little explored.

Objective
The objective of this paper is to present an interactive mindfulness-based technology to improve mental well-being in people who have experienced depression. The system, Anima, is a brain-computer interface that augments mandala coloring by providing a generative color palette based on the unfolding mindfulness states during the practice. In addition, this paper outlines a multiple-baseline, single-case experimental design methodology to evaluate training effectiveness.

Methods
Adult participants who have experienced depression in the past, have finished treatment within the last year, and can provide informed consent will be able to be recruited. The Anima system, consisting of 2 tablets and a nonintrusive mental activity headband, will be delivered to participants to use during the study. Measures include state and trait mindfulness, depression symptoms, mental well-being, and user experience, and these measures will be taken throughout the baseline, intervention, and monitoring phases. The data collection will take place in the form of a questionnaire before and after each mandala-coloring session and a semistructured interview every 2 weeks. Trial results will be analyzed using structured visual analysis, supplemented with statistical analysis appropriate to single-case methodology.

Results
Study results will offer new insights into the deployment and evaluation of novel interactive brain-computer interfaces for mindfulness training in the context of mental health. Moreover, findings will validate the effectiveness of this training protocol to improve the mental well-being of people who have had depression. Participants will be recruited locally through the National Health Service.

Conclusions
Evidence will assist in the design and evaluation of brain-computer interfaces and mindfulness technologies for mental well-being and the necessary services to support people who have experienced depression.

International Registered Report Identifier (IRRID)
PRR1-10.2196/20819
Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients
Authors: Letellier Thibault , Leborgne Florent , Kerleau Clarisse , Gaultier Aurélie , Dantal Jacques , Ville Simon ,   on behalf of Divat Consortium
Published: November 2020

Background and objectives
Keratinocyte cancers, which primarily comprise squamous cell carcinomas and basal cell carcinomas, represent a major concern and potential risk for kidney transplant recipients. Hydrochlorothiazide, a diuretic widely used to treat hypertension, has been implicated in skin photosensitivity reaction. Recent studies conducted in the general population have found that hydrochlorothiazide use is associated with a higher risk of keratinocyte cancer, especially squamous cell carcinomas. High-risk groups, however, including transplant recipients were excluded from these. Our aim was to investigate whether hydrochlorothiazide use was associated with keratinocyte cancer in kidney transplant recipients on immunosuppressive therapy.

Design, setting, participants, & measurements
In a single-center cohort of kidney (n=2155), combined kidney-pancreas (n=282), and pancreas (n=59) transplant recipients from the Données Informatisées VAlidées Transplantation (DIVAT) database transplanted between 2000 and 2017 in Nantes, France, we evaluated the association between hydrochlorothiazide exposure and keratinocyte cancers. Multivariable cause-specific, time-varying Cox models were used to estimate the relationship between hydrochlorothiazide exposure and the hazard of squamous cell carcinoma and basal cell carcinoma, with hydrochlorothiazide designated as the time-dependent variable.

Results
Among the participants, 279 of 2496 (11%) were exposed to hydrochlorothiazide after the transplantation. Cumulative incidence rates of keratinocyte cancer by 10 and 15 years were 7% and 9% for squamous cell carcinomas, respectively, and 8% and 11% for basal cell carcinomas, respectively. We found a relationship between exposure to hydrochlorothiazide and the risk of squamous cell carcinomas (hazard ratio, 2.04; 95% confidence interval, 1.27 to 3.28). In contrast, we found no association between hydrochlorothiazide exposure and basal cell carcinomas (hazard ratio, 0.63; 95% confidence interval, 0.35 to 1.15).

Conclusions
In a single-center cohort of kidney, combined kidney-pancreas, and pancreas transplant recipients, exposure to hydrochlorothiazide was associated with a two-fold higher risk of squamous cell carcinoma and no higher risk of basal cell carcinoma.
Religião e violência nos limites da experiência humana: um diálogo com Edward Schillebeeckx
Authors: Rocha Abdruschin Schaeffer , Rosa Wanderley Pereira da 
Published: November 2020

O presente artigo propõe-se a refletir sobre os limites da relação entre religião e violência tendo como referência principal o teólogo belga Edward Schillebeeckx. Com isso em foco, sugere a violência como algo que não necessariamente tem na religião sua origem, bem como procura mostrar que a religião também não pode ser atrelada automaticamente à violência ou mesmo à não violência. Seu ponto de partida é a conceituação de essencialismo, aplicado tanto à religião como à violência, uma vez que, conforme o ponto de vista dos autores, a categoria de análise essencialista fundamenta uma equivocada e apressada relação entre esses dois entes.
A HISTÓRIA DA FORMAÇÃO DO CORPUS HERMETICUM
Authors: Lira David Pessoa de 
Published: November 2020

Dezessete tratados herméticos foram conservados em um corpus. Deve-se perguntar a razão pela qual todos os dezessete tratados foram coligidos nesse corpus. Não obstante haver uma incidência de tratados πρὸς Τατ, πρὸς Ἀσϰληπιόν, πρὸς Ἄμμωνα tanto no Corpus Hermeticum como nos Stobaei Hermetica, deve-se salientar três pontos importantes: a) não se pode presumir facilmente nada, além dessa incidência, sobre as fontes que Estobeu empregou sem qualquer tipo de atestação; b) deve-se entender que o próprio Corpus Hermeticum é uma coletânea de textos de que não se pode pressupor uma fonte única e unívoca de todos os tratados ali coligidos; c) ao empregar as mesmas fontes, não está clara a razão pela qual se emprega alguns textos em detrimento de outros. Ao que tudo indica, o Corpus Hermeticum, embora compreendendo um conjunto de textos que remontam aos primeiros séculos da Era Cristã, é uma produção redacional seletiva e arbitrária do Período Bizantino no que diz respeito a sua formação enquanto coletânea de textos herméticos e unidade literária distinta. Assim, o ponto capital é a maneira como os textos herméticos foram reunidos e transmitidos e a motivação pela qual se optou por um conjunto de tratados herméticos, sinalizando, assim, o interesse pelas doutrinas e a sua interpretação em um determinado contexto.
Minoritetsetniske lesbiske i et intersektionelt intimt medborgerskabsperspektiv
Authors: Mørck Yvonne 
Published: November 2020

Da studier viser, at der er mere viden om minoritetsetniske homoseksuelle mænd end kvinder, fokuserer artiklen især på muslimske minoritetsetniske lesbiske og udforsker, hvilke identitetsmæssige udfordringer disse står over for i forbindelse med selvbestemmelse over deres seksuelle og romantiske liv. Den analytiske ramme består af begreberne intersektionalitet, intimt medborgerskab og patriarkalsk forbundethed. Det viser sig, at minoritetsetniske lesbiske navigerer i forhold til en vifte af intersektioner af kategorier og ulighedssystemer, der involverer sexisme, homofobi og racisme/racialisering i såvel deres familiemæssige, etnisk-religiøse baglande som i majoritetssamfundet, herunder i LGBT-miljøer. Artiklen diskuterer de forskelligartede intersektioner af kategorier, der kommer til udtryk som henholdsvis undertrykkende og ekskluderende magthierarkier og identitetsskabende processer, der involverer individuelle strategier til håndtering af deres multiple identiteter. På denne baggrund diskuteres fire strategier: fuld åbenhed, dobbeltliv, selektiv åbenhed og brud med familien. Set fra minoritetsetniske lesbiskes perspektiv er det ikke altid hverken hensigtsmæssigt eller ønskværdigt at vælge en åben strategi, som har været udbredt i den vestlige verden især siden1970’erne. Forandringsprocesser i forhold til intimitetsformer, som påvirker bl.a. køn, seksualitet og etnisk-religiøse dimensioner, indebærer imidlertid øgede muligheder for at udvikle nye hybride former for seksuelle/romantiske relationer og identitet(er) og dermed for udfoldelse af et mere selvvalgt intimt medborgerskab.
A systematic literature review of implementation six sigma in manufacturing industries
Authors: Setiawan Indra , Purba Humiras Hardi , Debora Fransisca 
Published: November 2020

The Six Sigma approach has received a lot of attention in various industrial sectors from the manufacturing industry to the service industry. More specific knowledge about Six Sigma has grown rapidly. Much of the training and research on Six Sigma is carried out in various industries and university. This literature review related to Six Sigma purpose to provide an overview of Six Sigma implementation in the manufacturing industries. The Six Sigma approach that has been introduced and implemented for a long time is DMAIC (Define, Measure, Analyze, Improve, and Control). This paper discusses the published literature related to Six Sigma ranging from 2015 to 2020. This paper involves the study review of 50 papers related to the implementation of Six Sigma of known database search including Elsevier, Science Direct, Emerald Insight and Google Scholars. This literature review contains results from a variety of different perspectives. The perspective includes the focus of the industry, the focus of the number of distribution by country, the focus of the year of publication and the focus of the number of publishers. In fact, this is useful for all types of manufacturing industries to find solutions to problems. The paper also provides advantages for researchers next to add to the literature.
Do Banks Price Firms' Data Breaches?
Authors: Huang Henry He , Wang Chong 
Published: November 2020

ABSTRACT
This paper studies the financial consequences of a reported data breach for bank loan terms. Using a staggered difference-in-differences approach with treatment and control samples matched by data breach propensity, we find that firms that have reported data breaches face higher loan spreads and their loans are more likely to require collateral and demand more covenants. The effects are more pronounced when the data breach involves criminal activities or the loss of a large number of records, or when the breached firm belongs to certain industries or has a high IT reputation. Moreover, using the introduction of state mandatory data breach notification laws as an exogenous shock, we find that the negative effect of data breaches on bank loan terms is more significant after these laws took effect. Our evidence also suggests that breached firms that take more remedial actions following the breach incident receive less unfavorable loan terms.
JEL Classifications: G10; G12.
Within-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study
Authors: Zhang Ping , Atkinson Karen M. , Bray George A. , Chen Haiying , Clark Jeanne M. , Coday Mace , Dutton Gareth R. , Egan Caitlin , Espeland Mark A. , Evans Mary , Foreyt John P. , Greenway Frank L. , Gregg Edward W. , Hazuda Helen P. , Hill James O. , Horton Edward S. , Hubbard Van S. , Huckfeldt Peter J. , Jackson Sharon D. , Jakicic John M. , Jeffery Robert W. , Johnson Karen C. , Kahn Steven E. , Killean Tina , Knowler William C. , Korytkowski Mary , Lewis Cora E. , Maruthur Nisa M. , Michaels Sara , Montez Maria G. , Nathan David M. , Patricio Jennifer , Peters Anne , Pi-Sunyer Xavier , Pownall Henry , Redmon Bruce , Rushing Julia T. , Steinburg Helmut , Wadden Thomas A. , Wing Rena R. , Wyatt Holly , Yanovski Susan Z. 
Published: November 2020

OBJECTIVE
To assess the cost-effectiveness (CE) of an intensive lifestyle intervention (ILI) compared with standard diabetes support and education (DSE) in adults with overweight/obesity and type 2 diabetes, as implemented in the Action for Health in Diabetes study.

RESEARCH DESIGN AND METHODS
Data were from 4,827 participants during their first 9 years of study participation from 2001 to 2012. Information on Health Utilities Index Mark 2 (HUI-2) and HUI-3, Short-Form 6D (SF-6D), and Feeling Thermometer (FT), cost of delivering the interventions, and health expenditures was collected during the study. CE was measured by incremental CE ratios (ICERs) in costs per quality-adjusted life year (QALY). Future costs and QALYs were discounted at 3% annually. Costs were in 2012 U.S. dollars.

RESULTS
Over the 9 years studied, the mean cumulative intervention costs and mean cumulative health care expenditures were $11,275 and $64,453 per person for ILI and $887 and $68,174 for DSE. Thus, ILI cost $6,666 more per person than DSE. Additional QALYs gained by ILI were not statistically significant measured by the HUIs and were 0.07 and 0.15, respectively, measured by SF-6D and FT. The ICERs ranged from no health benefit with a higher cost based on HUIs to $96,458/QALY and $43,169/QALY, respectively, based on SF-6D and FT.

CONCLUSIONS
Whether ILI was cost-effective over the 9-year period is unclear because different health utility measures led to different conclusions.
Pharmacokinetic and Pharmacodynamic Head-to-Head Comparison of Clinical, Equivalent Doses of Insulin Glargine 300 units · mL−1 and Insulin Degludec 100 units · mL−1 in Type 1 Diabetes
Authors: Lucidi Paola , Candeloro Paola , Cioli Patrizia , Marinelli Andreoli Anna , Pascucci Chiara , Gambelunghe Angela , Bolli Geremia B. , Fanelli Carmine G. , Porcellati Francesca 
Published: November 2020

OBJECTIVE
To prove equivalence of individual, clinically titrated basal insulin doses of glargine 300 units ⋅ mL−1 (Gla-300) and degludec 100 units ⋅ mL−1 (Deg-100) under steady state conditions in a single-blind, randomized, crossover study, on the glucose pharmacodynamics (PD) in people with type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Subjects with T1D (N = 22, 11 men, age 44.3 ± 12.4 years, disease duration 25.5 ± 11.7 years, A1C 7.07 ± 0.63% [53.7 ± 6.9 mmol ⋅ mL−1], BMI 22.5 ± 2.7 kg · m−2), naïve to Gla-300 and Deg-100, underwent 24-h euglycemic clamps with individual clinical doses of Gla-300 (0.34 ± 0.08 units ⋅ kg−1) and Deg-100 (0.26 ± 0.06 units ⋅ kg−1), dosing at 2000 h, after 3 months of optimal titration of basal (and bolus) insulin.

RESULTS
At the end of 3 months, Gla-300 and Deg-100 reduced slightly and, similarly, A1C versus baseline. Clamp average plasma glucose (0–24 h) was euglycemic with both insulins. The area under curve of glucose infused (AUC-GIR[0–24 h]) was equivalent for the two insulins (ratio 1.04, 90% CI 0.91–1.18). Suppression of endogenous glucose production, free fatty acids, glycerol, and β-hydroxybutyrate was 9%, 14%, 14%, and 18% greater, respectively, with Gla-300 compared with Deg-100 during the first 12 h, while glucagon suppression was no different. Relative within-day PD variability was 23% lower with Gla-300 versus Deg-100 (ratio 0.77, 90% CI 0.63–0.92).

CONCLUSIONS
In T1D, individualized, clinically titrated doses of Gla-300 and Deg-100 at steady state result in similar glycemic control and PD equivalence during euglycemic clamps. Clinical doses of Gla-300 compared with Deg-100 are higher and associated with quite similar even 24-h distribution of PD and antilipolytic effects.
A New Dual-cure Universal Simplified Adhesive: 18-month Randomized Multicenter Clinical Trial
Authors: de Albuquerque E Gomes , Warol F , Calazans F Signorelli , Poubel L Augusto , Marins S Soares , Matos T , de Souza JJ , Reis A , de Oliveira Barceleiro M , Loguercio AD 
Published: November 2020

Clinical RelevanceNon-carious cervical lesion restorations using a dual-cure universal adhesive in self-etch and etch-and-rinse mode showed satisfactory clinical performance after 18 months.SUMMARYObjectives: The objective of this multicenter, double-blind, split-mouth randomized clinical trial was to evaluate the clinical performance of a new dual-cure universal adhesive system (Futurabond U, Voco GmBH) when applied using different strategies over a period of 18 months.Methods and Materials: Fifty patients participated in this study. Two hundred non-carious cervical lesions were restored using the adhesive Futurabond U according to four adhesive strategies (n=50 per group): only self-etch (SEE), selective enamel etching + self-etch (SET), etch-and-rinse with dry dentin (ERDry), and etch-and-rinse with wet dentin (ERWet). After the adhesive application, cavities were restored using Admira Fusion composite resin. These restorations were evaluated according to FDI World Dental Federation criteria for the following characteristics: retention/fracture, marginal adaptation, marginal staining, postoperative sensitivity, and caries recurrence.Results: After 18 months, only four patients (12 months: one patient, n=4 restorations; and 18 months: three patients, n=12 restorations) were not evaluated. Fourteen restorations were lost after 18 months of clinical evaluation (four for SEE, three for SET, three for ERDry, and four for ERWet). The retention rates for 18 months (95% confidence interval) were 92% (81%–97%) for SEE, 94% (83%–97%) for SET, 94% (83%–97%) for ERDry, and 92% (81%–97%) for ERWet (p&gt;0.05). Thirty-eight restorations were considered to have minor discrepancies in marginal adaptation at the 18-month recall (13 for SEE, 13 for SET, six for ERDry, and six for ERWet; p&gt;0.05). Fourteen restorations were detected as a minor marginal discoloration at the 18-month recall (six for SEE, six for SET, one for ERDry, and one for ERWet; p&gt;0.05). However, all were considered clinically acceptable. No restorations showed postoperative sensitivity or caries recurrence at the time.Conclusion: The clinical performance of the Futurabond U did not depend on the bonding strategy used, and it was considered reliable after 18 months of clinical evaluation, although more marginal discrepancy was observed in the self-etch group.