bluuebunny/crossref_metadata_2025_split huggingface dataset:
Septische Granulomatose als seltene Differenzialdiagnose rezidivierender pulmonaler Infektionen bei Erwachsenen
Authors: Kleymann J. , Schütz C. , Körholz J. , Taube F. , Vogler M. , Halank M. , Kolditz M. , Langner S. , Geberzahn L. , Holotiuk O. , Roesler J. , Koschel D. 
Published: July 2020

ZusammenfassungDie septische Granulomatose (engl.: chronic granulomatous disease, CGD) ist bei Kindern und Jugendlichen mit häufigen Infektionen durch bestimmte Erreger differenzialdiagnostisch zu berücksichtigen.In vorliegender Kasuistik berichten wir über eine 64-jährige Patientin mit über Jahre zunehmenden bronchopulmonalen Infektionen, teilweise durch seltene Erreger, Autoimmunphänomenen, Malignomen und im weiteren Verlauf rezidivierenden organisierenden Pneumonien (OP) mit Nachweis von Granulomen. Ursächlich wurde bei der Patientin eine septische Granulomatose, Unterform p47phox-Defizienz diagnostiziert. Ein Überleben von Patienten mit einem primären Immundefekt (PID) bis ins hohe Erwachsenenalter wird trotz wiederholter Komplikationen in Einzelfällen beobachtet, insbesondere wenn die defekte Zellstruktur eine Restaktivität aufweist. Bei rezidivierenden bronchopulmonalen Infektionen insbesondere durch bestimmte seltene Erreger und in Kombination mit organisierend-granulomatösen Lungenreaktionen sowie Autoimmunphänomenen ist auch bei älteren Erwachsenen an eine CGD zu denken. Durch eine Diagnoseverzögerung kommt es oft zu einem erheblichen Anstieg der Morbidität und Mortalität.
Sclerotherapy – How to Achieve a Spectacular Outcome
Authors: Mann Margaret W. 
Published: July 2020

AbstractWhen performed correctly, sclerotherapy results in fibrous occlusion that is not amenable to recanalization. Paramount to success is adequate contact time of a sclerosant to the endothelial cells to cause sufficient damage to the vein while minimizing side effects. To optimize sclerotherapy results, one needs to choose the right patient and the right vein and then use the proper sclerosing agent and injection techniques. This paper will review current literature on sclerotherapy, as well as tips and tricks to optimize outcome and minimize complications.
Elevated Intraocular Pressure in Burn Patients Undergoing Fluid Resuscitation: An Opportunity to Avoid Orbital Compartment Syndrome
Authors: Shen Christine Y. , Woody Spencer , Fuller Spencer D. , Grange Landon K. , Tran Kimberly D. , Lee Jeanne G. , Kikkawa Don O. , Lee Jeffrey E. 
Published: July 2020

Abstract
Objective This study aims to discuss clinical characteristics of burn patients who developed elevated intraocular pressure (IOP). We propose management strategies to prevent orbital compartment syndrome before invasive treatment is required.
Methods A retrospective review of 47 burn patients at the University of California San Diego (UCSD), Burn Intensive Care Unit (ICU; major regional burn center for San Diego county), was analyzed for demographics, fluid resuscitation volumes, and physical exam findings. Patients requiring topical treatment for high-IOP, defined as ≥30 mm Hg in either or both eyes, were compared with those who did not require treatment, using the t-test and Fisher's exact test. Linear regression tested for an association between peak IOP and fluid volume. Logistic regression evaluated the association between total fluid and treatment of high IOP, while adjusting for other characteristics.
Results Six of 47 patients required IOP-lowering treatment. Of the patients requiring treatment, one drop of dorzolamide/timolol in both eyes twice daily was the most common treatment recommendation. Presence of periocular burns was a significant risk factor in patients who required treatment for high IOP. No patients developed orbital compartment syndrome or required surgical intervention to lower IOP. The mean total fluid volume delivered in the first 24 hours was 0.8 times the level prescribed by fluid resuscitation guidelines.
Conclusion By treating early clinical signs and properly managing fluid resuscitation, development of orbital compartment syndrome in burn patients can be avoided.
Statin use and discontinuation in Danes age 70 and older: a nationwide drug utilisation study
Authors: Thompson Wade , Jarbøl Dorte Ejg , Nielsen Jesper Bo , Haastrup Peter , Pottegård Anton 
Published: July 2020

Abstract

Background and objective
There is limited evidence on the clinical effects of statins in older persons. We aimed to explore statin use and discontinuation patterns in Danes age 70 and older.

Design
Register-based drug utilisation study.

Setting
Danish nationwide health registries.

Subjects
All Danish persons aged ≥70 years between 2011 and 2016.

Measurements
(1) Monthly prevalence and (2) quarterly incidence of statin use, (3) characteristics of new users, (4) total amount of statin redeemed, (5) statin discontinuation rate between 2014 and 2016 in long-term statin users and (6) factors associated with discontinuation.

Results
We identified 395,279 unique older statin users between 2011 and 2016. The prevalence increased from 30% in 2011 to 33% in 2016 (23% for primary prevention and 56% for secondary prevention in 2016). The quarterly incidence fell from 11 per 1,000 persons in 2011 to 7 per 1,000 persons in 2016. The prevalence was generally stable in those 70 to 79 years. In those aged ≥80 years, the prevalence increased despite decreasing incidence. The proportion of persons initiating for primary prevention decreased from 58% in 2011 to 52% in 2016. Approximately 19% of long-term statin users discontinued therapy between 2014 and 2016. Increasing age was the strongest predictor of statin discontinuation.

Conclusions
Approximately one in three Danes age ≥ 70 years were taking statins in 2016. The characteristics of incident users shifted between 2011 and 2016, with less people age 80 and older starting on statins and fewer people starting for primary prevention.
A pilot with a helicopter in the left atrium: a case report of an embolized Watchman device
Authors: Halim Jonathan , Tavernier Rene , Missault Luc , Debonnaire Philippe 
Published: July 2020

Abstract

Background
Embolization of a Watchman device in patients undergoing percutaneous left atrial appendage (LAA) closure is a rare complication. Retrieval of the device can be achieved percutaneously with a snaring technique or a bioptome.

Case summary
We present an illustrative case of Watchman closure device embolization during an LAA closure attempt in a 77-year-old man. The complication was caused by anatomical restraints of the LAA, in particular limited depth resulting in poor stability of the closure device after implantation. By the use of a double snaring technique, however, we managed to retrieve the device percutaneously. By applying such strategy, a more invasive surgical approach can be prevented.

Discussion
Prompt response is needed when embolization of a Watchman device occurs. A snaring technique can be used in most cases to attempt device retrieval. A double snaring technique is in this case associated with higher retrieval success than a single snaring technique.
Prevalence of torture and trauma history among immigrants in primary care in Denmark: do general practitioners ask?
Authors: Ostergaard Liv Stubbe , Wallach-Kildemoes Helle , Thøgersen Marie H , Dragsted Ulrik B , Oxholm Annemette , Hartling Ole , Norredam Marie 
Published: July 2020

Abstract

Background
Torture survivors typically present with varied and complex symptoms, which may challenge assessment by general practitioners (GPs). This study explored the prevalence of torture and trauma history among immigrants born in non-Western countries presenting to GPs in Denmark and the extent to which GPs ask this population about torture or trauma history.

Methods
Based on a self-reported questionnaire among non-western immigrant patients, we used bivariate analyses to determine the prevalence of torture and trauma history and the proportion of patients being asked by their GP about this. Data were analysed using multivariate logistic regression.

Results
From 46 GP clinics, 300 questionnaires were finalized by immigrant patients. Twenty-eight percent of the patients had a history of torture. Of these, significantly more were men (70%) than women (29%). About half of the torture survivors (55%) had been asked by their GP about torture history. The odds ratio (OR, 95% confidence interval) for being asked about torture history by the GP was 1.28 (0.46–3.53) among women compared with men. Compared with Southeast Europe, OR for being a torture survivor among male immigrants from Middle East-North African region and South and East Asia was 1.83 (0.81–4.15) and 0.25 (0.08–0.82), respectively.

Conclusions
Our results suggest that torture and trauma are widespread among immigrants presenting to GPs. In our study, the GPs had managed to detect half of the torture survivors. A more systematic approach to detection in General Practice is advisable, and more knowledge on how and when to ask is needed.
Towards real-time monitoring: data assimilated time-lapse full waveform inversion for seismic velocity and uncertainty estimation
Authors: Huang Chao , Zhu Tieyuan 
Published: July 2020

SUMMARYRapid development of time-lapse seismic monitoring instrumentations has made it possible to collect dense time-lapse data for tomographically retrieving time-lapse (even continuous) images of subsurface changes. While traditional time-lapse full waveform inversion (TLFWI) algorithms are designed for sparse time-lapse surveys, they lack of effective temporal constraint on time-lapse data, and, more importantly, lack of the uncertainty estimation of the TLFWI results that is critical for further interpretation. Here, we propose a new data assimilation TLFWI method, using hierarchical matrix powered extended Kalman filter (HiEKF) to quantify the image uncertainty. Compared to existing Kalman filter algorithms, HiEKF allows to store and update a data-sparse representation of the cross-covariance matrices and propagate model errors without expensive operations involving covariance matrices. Hence, HiEKF is computationally efficient and applicable to 3-D TLFWI problems. Then, we reformulate TLFWI in the framework of HiEKF (termed hereafter as TLFWI-HiEKF) to predict time-lapse images of subsurface spatiotemporal velocity changes and simultaneously quantify the uncertainty of the inverted velocity changes over time. We demonstrate the validity and applicability of TLFWI–HiEKF with two realistic CO2 monitoring models derived from Frio-II and Cranfield CO2 injection sites, respectively. In both 2-D and 3-D examples, the inverted high-resolution time-lapse velocity results clearly reveal a continuous velocity reduction due to the injection of CO2. Moreover, the accuracy of the model is increasing over time by assimilating more time-lapse data while the standard deviation is decreasing over lapsed time. We expect TLFWI-HiEKF to be equipped with real-time seismic monitoring systems for continuously imaging the distribution of subsurface gas and fluids in the future large-scale CO2 sequestration experiments and reservoir management.
Worker flows, reallocation dynamics, and firm productivity: new evidence from longitudinal matched employer–employee data
Authors: Grinza Elena 
Published: July 2020

AbstractThis article investigates the impact of the worker flows of a firm on productivity by using unique longitudinal matched employer–employee data. The analysis has split a firm’s total worker flows into three components: workers’ replacements (excess worker flows), hirings introduced to increase the firm’s employment level (net hirings), and separations of workers intended to decrease the firm’s workforce (net separations). This has allowed the impact of workers’ replacements, which represent the most prominent and compelling feature of worker mobility, to be isolated from the other two components. Endogeneity has been dealt with by using a modified version of Ackerberg et al.'s (2015, Econometrica, 83(6), 2411–2451) control function method, which explicitly accounts for firm-fixed effects. The main findings are that (i) excess flows have an inverted U-shape impact on productivity, (ii) net hirings foster firm productivity, and (iii) net separations damage it. The impacts are heterogeneous and vary widely on the basis of the types of replacements, the categories of workers involved, and the types of firms experiencing such flows. Overall, the findings of this article highlight the importance of reallocation dynamics to obtain better employer–employee matches, and call for a reconsideration of policies concerning the flexibility of the labor market.
JEEA-FBBVA LECTURE 2019: Consumption Insurance in Networks with Asymmetric Information: Evidence from Tanzania
Authors: Attanasio Orazio , Krutikova Sonya 
Published: July 2020

Abstract
This paper uses a dataset from Tanzania with information on consumption, income, and income shocks within and across family networks. Crucially and uniquely, it also contains data on the degree of information existing between each pair of households within family networks. We use these data to construct a novel measure of the quality of information both at the level of household pairs and at the level of the network. We also note that the individual level measures can be interpreted as measures of network centrality. We study risk sharing within these networks and explore whether the rejection of perfect risk sharing that we observe can be related to our measures of information quality. We show that households within family networks with better information are less vulnerable to idiosyncratic shocks. Furthermore, we show that more central households within networks are less vulnerable to idiosyncratic shocks. These results have important implications for the characterisation of the empirical failure of the perfect risk-sharing hypothesis and point to the importance of information frictions.
International labour migration and the many forms of poverty
Authors: Nogales Ricardo , Oldiges Christian 
Published: July 2020

Abstract
The discourse on migration and poverty has largely shown that international labour migration reduces monetary poverty for the migrant-sending households. With the international consensus that poverty is multidimensional and goes beyond income alone, many studies evaluate the nexus between migration and non-monetary aspects of life, such as education and health. These show mixed evidence. Far fewer studies assess whether suffering from simultaneous deprivations in multiple indicators of well-being is affected by migration—which would be a full multidimensional poverty analysis at the household level. To assess the value-added of the latter, we empirically compare three approaches to measure poverty and the effect of migration on the three. These are (1) a solely monetary approach, (2) a dashboard approach that considers several non-monetary well-being deprivations, and (3) a counting approach that evaluates whether the multiple deprivations manifest themselves jointly. Using household panel data for rural Bangladesh, we assess how the association between international labour migration and poverty among the stay-behind household members changes in light of the three approaches. The endogenous nature of migration in this connection is explicitly addressed by applying a Hausman–Taylor estimation procedure. We corroborate that poverty is related to a lower likelihood of being monetary poor, but we do not find that it is associated with an increased likelihood of exiting multidimensional poverty altogether. However, we do find that it is associated with a lower likelihood of facing simultaneous deprivations in terms of sanitation, electricity, and asset-ownership among those who live in multidimensional poverty.
Long-term study of extreme giant pulses from PSR B0950+08 with AARTFAAC
Authors: Kuiack Mark , Wijers Ralph A M J , Rowlinson Antonia , Shulevski Aleksandar , Huizinga Folkert , Molenaar Gijs , Prasad Peeyush 
Published: July 2020

ABSTRACT
We report on the detection of extreme giant pulses (GPs) from one of the oldest known pulsars, the highly variable PSR B0950+08, with the Amsterdam-ASTRON Radio Transient Facility And Analysis Centre (AARTFAAC), a parallel transient detection instrument operating as a subsystem of the LOw Frequency ARray (LOFAR). During processing of our Northern Hemisphere survey for low-frequency radio transients, a sample of 275 pulses with fluences ranging from 42 to 177 kJy ms were detected in one-second snapshot images. The brightest pulses are an order of magnitude brighter than those previously reported at 42 and 74 MHz, on par with the levels observed in a previous long-term study at 103 MHz. Both their rate and fluence distribution differ between and within the various studies done to date. The GP rate is highly variable, from 0 to 30 per hour, with only two 3-h observations accounting for nearly half of the pulses detected in the 96 h surveyed. It does not vary significantly within a few-hour observation, but can vary strongly one from day to the next. The spectra appear strongly and variably structured, with emission sometimes confined to a single 195.3 kHz subband, and the pulse spectra changing on a time-scale of order 10 min.
Multiple Merger Genealogies in Outbreaks ofMycobacterium tuberculosis
Authors: Menardo Fabrizio , Gagneux Sébastien , Freund Fabian 
Published: July 2020

AbstractThe Kingman coalescent and its developments are often considered among the most important advances in population genetics of the last decades. Demographic inference based on coalescent theory has been used to reconstruct the population dynamics and evolutionary history of several species, including Mycobacterium tuberculosis (MTB), an important human pathogen causing tuberculosis. One key assumption of the Kingman coalescent is that the number of descendants of different individuals does not vary strongly, and violating this assumption could lead to severe biases caused by model misspecification. Individual lineages of MTB are expected to vary strongly in reproductive success because 1) MTB is potentially under constant selection due to the pressure of the host immune system and of antibiotic treatment, 2) MTB undergoes repeated population bottlenecks when it transmits from one host to the next, and 3) some hosts show much higher transmission rates compared with the average (superspreaders).Here, we used an approximate Bayesian computation approach to test whether multiple-merger coalescents (MMC), a class of models that allow for large variation in reproductive success among lineages, are more appropriate models to study MTB populations. We considered 11 publicly available whole-genome sequence data sets sampled from local MTB populations and outbreaks and found that MMC had a better fit compared with the Kingman coalescent for 10 of the 11 data sets. These results indicate that the null model for analyzing MTB outbreaks should be reassessed and that past findings based on the Kingman coalescent need to be revisited.
Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts
Authors: Holstein Ingo , Singh Anurag Kumar , Pohl Falk , Misiak Danny , Braun Juliane , Leitner Laura , Hüttelmaier Stefan , Posern Guido 
Published: July 2020

Abstract
The differentiation and regeneration of skeletal muscle from myoblasts to myotubes involves myogenic transcription factors, such as myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF). In addition, post-transcriptional regulation by miRNAs is required during myogenesis. Here, we provide evidence for novel mechanisms regulating MRTF-A during myogenic differentiation. Endogenous MRTF-A protein abundance and activity decreased during C2C12 differentiation, which was attributable to miRNA-directed inhibition. Conversely, overexpression of MRTF-A impaired differentiation and myosin expression. Applying miRNA trapping by RNA affinity purification (miTRAP), we identified miRNAs which directly regulate MRTF-A via its 3′UTR, including miR-1a-3p, miR-206-3p, miR-24-3p and miR-486-5p. These miRNAs were upregulated during differentiation and specifically recruited to the 3′UTR of MRTF-A. Concomitantly, Ago2 recruitment to the MRTF-A 3′UTR was considerably increased, whereas Dicer1 depletion or 3′UTR deletion elevated MRTF-A and inhibited differentiation. MRTF-A protein expression was inhibited by ectopic miRNA expression in murine C2C12 and primary human myoblasts. 3′UTR reporter activity diminished upon differentiation or miRNA expression, whereas deletion of the predicted binding sites reversed these effects. Furthermore, TGF-β abolished MRTF-A reduction and decreased miR-486-5p expression. Our findings implicate miR-24-3p and miR-486-5p in the repression of MRTF-A and suggest a complex network of transcriptional and post-transcriptional mechanisms regulating myogenesis.
Career Guidance: Living on the Edge of Public Policy
Authors: McCarthy John , Borbély-Pecze Tibor Bors 
Published: July 2020

Abstract
Public policy formation and implementation for career guidance provision are complex issues, not least because in most countries career guidance is a peripheral part of legislation for education, employment, and social inclusion. Policy solutions are compromises by nature. Regulations and economic incentives are the main policy instruments for career guidance provision, but there is often incoherence between the intentions of the regulations and the economic incentives provided for policy implementation. The intermediary organizations that serve to implement policy add significant variability to policy effects. International bodies and organizations have shown significant interest in the role of career guidance in education and employment policies through the undertaking of policy reviews, the formulation of recommendations for career guidance, and, in some cases, providing economic incentives to support their implementation. However, there is a dearth of evaluation studies of policy formation and implementation at the national level.
Mesoscale, Microscale, and Numerical Models
Authors: Hawbecker Patrick 
Published: July 2020

Abstract
Numerical models have been instrumental in analyzing the wind field of non-synoptic wind storms as it is very difficult to obtain a complete data set from observations alone. Depending on the application, one must decide between mesoscale modeling, microscale modeling, or a combination of the two. Mesoscale modeling considers the full extent of the physics involved in the atmosphere but is limited in the spatiotemporal resolution that can be achieved. On the other hand, microscale modeling can produce a high-fidelity simulation of the wind field, but often lacks in the extent of the physics and physical mechanisms that are simulated. Applications and limitations of these modeling techniques are discussed, as well as the future direction of mesoscale and microscale modeling of non-synoptic wind storms.