bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of CLDN18 as a potential diagnostic biomarker and therapeutic target for pancreatic cancer based on multiomic analysis
Authors: Li Jian , Zhang Yao , Hu Dengmin 
Published: February 2020

Abstract
Background

Claudin 18 (CLDN18) is a transmembrane protein localized in the apical regions to form a tight-junction complex. The expression of CLDN18 was restricted to normal lung and stomach tissues but was aberrantly activated in some types of cancers, and this molecule can serve as a promising target for targeted treatment.

Methods

The mRNA expression, genetic variations and prognostic values of CLDN18 in pancreatic cancer (PC) were analyzed using public data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein Atlas (HPA) databases and multiple online tools. The role of cyclic AMP-responsive element binding protein (CREB) and DNA methylation in regulating the expression of CLDN18 was determined by correlation analysis.

Results

The expression of CLDN18 was restricted to the lung and stomach in normal tissues, but was ectopically overexpressed in PC. CLDN18 mRNA expression was higher in cancers with advanced local invasion, later clinical stage, infiltrating duct or mucinous carcinoma types. Genetic variations of CLDN18 are rarely observed in PC. Correlation analysis revealed that CREB3L1, CREB3L3, and CREB3L4 were significantly positively coexpressed with CLDN18, and CLDN18 expression increased as methylation gradually decreased. The expression of CLDN18 was not observed to plays a role in predicting the survival of PC patients.

Conclusions

This data-driven study summarizes the expression features of CLDN18 in PC and demonstrates that it may serve as an ideal biomarker and therapy target for PC.
Potential function and molecular mechanism of circRNAs involved in idiopathic pulmonary fibrosis
Authors: Li Fangwei , Wang Hong , Tao Hongyan , Wu Fanqi , Wang Dan , Wan Yixin 
Published: February 2020

Abstract
Background: Recent studies have found a regulatory role of circular RNAs (circRNAs) in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the function and underlying molecular mechanism of circRNAs involved in IPF are uncertain and incomplete. This study aimed to further provide some critical information for the circRNA function in IPF using bioinformatic analysis. Methods: We searched in the NCBI (National Center for Biotechnology Information) Gene Expression Omnibus (GEO) database to find the circRNA expression profiles of human IPF. The microarray data GSE102660 was obtained and differentially expressed circRNAs were identified through R software. Results: 6 significantly up-regulated and 13 significantly down-regulated circRNAs were identified involved in the pathogenesis of IPF. The binding sites of miRNAs for each differentially expressed circRNA were also predicted and circRNA-miRNA-mRNA networks were constructed for the most up-regulated hsa_circ_0004099 and down-regulated hsa_circ_0029633. In addition, GO and KEGG enrichment analysis revealed the molecular function and enriched pathways of the target genes of circRNAs in IPF.Conclusion: These findings suggest that candidate circRNAs might serve an important role in the pathogenesis of IPF. Therefore, these circRNAs might be potential biomarkers for diagnosis and promising targets for treatment of IPF, which still need further veriﬁcation in vivo and in vitro.
Pure total flavonoids from citrus attenuate non-alcoholic fatty liver disease in mice via the gut microbiota
Authors: He Beihui , Jiang Jianping , Shi Zheng , Cui Dawei , Xu Sumei , Yan Maoxiang , Zhang Shuo , Chen Zhiyun 
Published: February 2020

Abstract
Background

An increasing number of studies suggest that gut microbiota composition and structure contribute to the pathophysiology of non-alcoholic fatty liver disease(NAFLD),and the gut microbiota has been proposed as a new target in the treatment of diet-induced NAFLD. In this study, we aimed to investigate the effects of pure total flavonoids from citrus (PTFC) on NAFLD and gut microbiota dysbiosis in high-fat diet (HFD)-fed mice and to further investigate whether the attenuation of NAFLD is related to the modulation of the gut microbiota.

Results

PTFC intervention could significantly attenuate symptoms in mice with HFD-induced NAFLD.Based on the results of 16S rDNA sequencing, PTFC treatment could increase the phylogenetic diversity of the HFD-induced microbiota. PTFC intervention could significantly restore the HFD-induced increases in the relative abundances of Bacteroidaceae and Christensenellaceae.

Conclusion

Our results suggested that PTFC could serve as a novel candidate for the prevention of NAFLD by modulating the gut microbiota.
Changes in the vaginal microbiota associated with primary ovarian failure
Authors: Wang Juan , Xu Jieying , Han Qixin , Chu Weiwei , Lu Gang , Chan Wai-Yee , Qin Yingying , du yanzhi 
Published: February 2020

Abstract
Background Primary ovary failure (POF) is defined as follicular failure in women of reproductive age. Although many factors are speculated to contribute to the occurrence of POF, the exact aetiology is unclear. Alterations in the microbiome of women with POF are poorly studied; Methods This study investigated the vaginal microbiota of 22 patients with POF and 29 healthy individuals. High-throughput Illumina Miseq sequencing targeting the V3-V4 region of the 16S ribosomal RNA (rRNA) gene was used to evaluate the relationships between vaginal flora and clinical characteristics of POF. Results Different from before, we found the diversity and richness of the vaginal flora of patients with POF was significantly different to that of healthy controls. Comparison of the flora of patients POF with that of menopausal women revealed that the relative abundance of Lactobacillus was significantly reduced in the latter, and women with reduced relative abundance of Lactobacillus in microbiota community decreased the pregnancy success rate at term. This study confirms that vaginal microbiota dysbiosis occurs in patients with POF. Additionally, the vaginal microbiota is closely related to clinical characteristics of POF and the inclusion of a disease verification model could reveal more accurate information related to the composition of the microbiota and its functions. Conclusion The result suggests the present study enabled identification of microbiota associated with POF, further investigations of differences in the microbiota in the context of POF will improve our understanding of the pathogenesis of the disease which involve modification of the vaginal microbiota.
TUTORIAL PENDIDIKAN AGAMA ISLAM DI UNIVERSITAS NEGERI YOGYKARTA
Authors: Achmad Widodo Syukri Fathudin 
Published: February 2020

Tutorial Pendidikan Agama Islam (PAI) merupakan kegiatan kokurikuler yang menekankan pada pendalaman dan penguasaan keterampilan praktek ibadah dan baca tulis Al-Qur'an yang diwajibkan kepada mahasiswa yang mengambil mata kuliah Pendidikan Agama Islam.Artinya kegiatan tutorial PAI melekat pada mata kuliah ini.Sedangkan pelaksanaannya dilakukan oleh para tutor PAI. Tutor PAI adalah mahasiswa yang telah memenuhi syarat khusus melalui seleksi, pelatihan dan mendapatkan mandat dari dosen PAI. Pada perkembangan selanjutnya tutorial PAI merupakan sarana menyebarkan nilai-nilai Islam yang bertujuan untuk memberikan pendalaman dan penguasaan tambahan keislaman bagi mahasiswa di luar materi perkuliahan pendidikan Agama Islam. Dengan tutorial PAI diharapkan terbentuk sosok pribadi muslim yang utuh, tangguh, menjadi suri tauladan dan sanggup menyebarkan Dakwah Islam (Agent of Change and Inovation) kepada warga kampus maupun masyarakat umum.
PLURALISME HUKUM ISLAM, SEBUAH PEMBACAAN AWAL
Authors: Setiawan Benni 
Published: February 2020

Pluralisme meniscayakan adanya kesediaan antarpemeluk agama dan keagamaan untuk berdialog, saling berbicara, dan saling mendengar. Dialog yang dikembangkan bukan semata dialog teologi, tetapi juga dialog kehidupan, dialog kegiatan sosial, berbagi pengalaman keagamaan, dan do’a bersama. Hukum Islam berdiri di atas prinsip-prinsip yang harus dipertahankan secara absolut dan universal. Prinsip-prinsip tersebut adalah ajaran yang qath'i dan menjadi tolok ukur pemahaman dan penerimaan hukum Islam secara keseluruhan. Pluralisme hukum Islam (Islamic legal pluralism) penting dibahas untuk memberikan gambaran yang jelas mengenai makna dan interpretasi sesuai konteks zaman. Aturan-aturan dalam hukum Islam yang kelihatannya tidak sesuai dengan prinsip egaliter dan dan prinsip-prinsip lainnya, maka aturan tersebut harus dipahami sesuai dengan konteks realitas sosial yang melingkupinya dan memperhatikan fungsinya sebagai legal counter terhadap aturan-aturan hukum non-egaliter yang berlaku pada masa Jahiliyyah. Kata kunci: pluralisme, hukum Islam
THE DIALECTICS OF JAVANESE AND ISLAMIC CULTURES: AN INTRODUCTION TO KUNTOWIJOYO’S THOUGHT
Authors: ZTF Pradana Boy 
Published: February 2020

AbstractThe main idea of this paper is to show the attempts made by Kuntowijoyo, anIndonesian unrivalled great thinker, to synthesize Javanese and Islamic worldviews through his writings. Kuntowijoyoıs thought is much influenced by his social circumstances. This manifested in the values, philosophies, and worldviews he was attempting to synthesize. One of Kuntowijoyoıs concerns is demystification. In this context, it is not surprising that the presentation of mythical practices in Javanese society is somehow dominant. The presentation is not intended as an agreement, but rather as evidences on the irrationality of the myths.Another aspect that should be underlined is Sufism and transcendence. In this aspect, the synthesis of Javanese and Islamic elements are a bit more visible as represented in his novel Khutbah di Atas Bukit that is seen as that is seen as resemblance of Kisah Dewa Ruci in Javanese literature by many observers.Key words: Dialectics, Javanese Thought.
POLEMIK EPISTEMOLOGI PANCASILA DAN DEMOKRASI YANG KONSTRUKTIF BESERTA IMPLEMENTASINYA
Authors: Tasma Agustinus Edward , Santoso Heru 
Published: February 2020

As cristalization values of Indonesion basics, Pancasila has reflections of our self of Nations. Pancasila has representation of everything differents in Nusantara Islands. With Pancasila it can be used on missions for our governents. In Indonesian conditions has wached essential of Pancasila as phylosophies groundlach and we have concern of phylosophy as way of live by differents in Indonesian governent.
PENGINGKARAN HAK MASYARAKAT ADAT ATAS TANAH ULAYAT OLEH KEBIJAKAN KEHUTANAN
Authors: Widihastuti Setiati 
Published: February 2020

Forest is the part of customary system of the tribe society. However, the forest management done by them is not facilitated in the forestry policy. The centralistic forestry policy causes the overlapping conception of the tribe forest to the state forest. While it formal normative aspect causes the acces of the tribes to the forest closed and causes reduction of wisdom-based supervision conducted by them. In fact, the community wisdom-based supervision in the socio-culture potential needing a revitalization and development as the new basis of the change of natural resources management policy which is recently controlled by the goverment proved to be the cause of law and economy harassment to the tribes society of Indonesia. Now we need to change the perception about the forest natural recource management policy controlled only by the government of the forestry instances. It should be the policy based on the community and its development principles to realize the regulation of the forest natural resources consumption. Therefore, the area division is needed to overcome the problems.
FILSAFAT JAWA DALAM SERAT WEDHATAMA
Authors: Wibawa Sutrisna 
Published: February 2020

This study aims to explore and formulate a philosophical concepts of Javanese Philosophy in Serat Wedhatama. The data sources were Serat Wedhatama. The data were analyzed using a hermeneutics method. The findings as follows Serat Wedhatama contains noble teachings to develop the spiritual aspect which became oneof the Javanese’s basic spiritual activityappreciations. The final of spiritual activity which taughtby Serat Wedhatama is to find the true life, better self-understanding, manunggaling kawula-Gusti, and to receive the grace of God by seeing the secrets of supernatural things. This is in accordance with the Javanese’s philosophy, which emphasizes the importance of the perfection of life (Ngudi kasampurnan), that humanis alwaysconnected to the environment, namely God and the universe, and believes the unity of Him (manunggaling kawula Gusti). Key words: Javanese Philosophy, Serat Wedhatama
MAKNA FILOSOFIS BANGUNAN KRATON SURAKARTA
Authors: Purwadi - 
Published: February 2020

This article will describe about symbolic meaning and phylosophy value in Kraton Surakarta.In 1745 Sunan Paku Buwono II moved his court to nearby Surakarta where he had built a new palace. When the king ordered to move the capital city of Kartasura eastward to the banks of Javas longest river, it was certainly not without reasons. At that time over land communica­tion was scarce because of inaccesible swamps, high mountain ranges and impenetrable forests. But the city must have its outlet, its contact with outer islands and Bengawan then was the only economic and social life line. Keyword: Kraton Surakarta, phylosophy, symbolic
TOPIKALISASI SEBAGAI SARANA MEMAHAMI ISI WACANA SERAT SANA SUNU
Authors: Meilawati Avi 
Published: March 2020

This research aims to describe the topics in the ninth chapter of Serat Sana Sunu, how the topicalization and what topics which build the discoure. It consists of 34 stanza The theme on chapter IX focuses on how to say politely. The data collects by reading and noting. The data analyzing by finding the topiks from each stanza, each sentence, and word. The second step is describing the data through the descriptive way. There are two types of topicalitation. First, the author describes the topic full in one paragraph. Second, the topic separate in many paragraps. The starting topic is not only in the first line each paragraph, but also in the middle or in the last line. There are two big theme in the chapter; the seven talking interdiction and the polite way to say in many conditions. The seven interdictions are lie, gossip, say something bad about someone else, arrogant, say jokingly, conceited, and say something unuseful. The other commands are to say in polite way to brother, sister; politeness as a servant, and the way to say in a meeting or forum. The rules in chapter IX from Serat Sana Sunu can be used as a reminder to be polite. It also can be an alternative way to solve the young generation problem to say in a better way. Keywords: topic, Serat Sana Sunu
UNSUR KEBUDAYAAN JAWA DALAM TEKS PAMORIPUN SARÉNGAT, TARÉKAT, KAKÉKAT, LAN MAKRIFAT
Authors: Mulyani Hesti 
Published: February 2020

Teks Pamoripun Saréngat, Tarékat, Kakékat, lan Makrifat adalah salah satu teks yang dimuat di dalam naskah Sêrat Suluk Rasa Sêjati. Teks tersebut termasuk di dalam pengelompokan teks sastra jenis suluk atau piwulang. Teks jenis suluk atau piwulang berisi uraian tentang ajaran manunggal-nya hamba dengan Tuhannya (manunggaling kawula Gusti), yakni perjalanan batin manusia dalam mencapai kesempurnaan hidup. Untuk menggali, mengungkapkan, dan memaknai ajaran manunggaling kawula Gusti yang terdapat di dalam teks PSTKM, yakni syariat, tarekat, hakikat, dan makrifat dilakukan dengan mendeskripsikan bentuk gubahan, membuat alih tulis, dan menganalisis isinya secara deskriptif. Analisis isi teks dilakukan berdasarkan tujuh unsur kebudayaan dengan penekanan pada unsur kebahasaan, kesusastraan, dan kebudayaan.Hasil dan pembahasan bentuk dan isi yang terkandung dalam teks PSTKM meliputi: (1) unsur kebahasaan: aksara yang digunakan untuk menuliskan teks, memahami rangkaian kata-kata puitis, membuat parafrase, dan terjemahan teks; (2) unsur kesusastraan: bentuk gubahan yang dipergunakan adalah puisi tradisional Jawa (têmbang macapat) dengan matra tunggal Dhandhanggula yang berwatak fleksibel dan menyenangkan, konvensi têmbang Dhandhanggula; dan (3) unsur kebudayaan: konsep manunggaling kawula Gusti, yakni syariat, tarekat, hakikat, dan makrifat sebagai sarana menuju insan kamil atau manusia berada sedekat-dekatnya dengan Tuhan. Kata kunci: unsur kebudayaan Jawa, naskah - teksAbstrakText Pamoripun Saréngat, Tarékat, Kakékat, lan Makrifat are some of texts in Sêrat Suluk Rasa Sêjati literature, as suluk or piwulang literature. The Suluk literature contains the doctrine of the unity of man into their God. It is like the journey to reach the perfection of life.The data were analyzed descriptively based on the description of literary work, translation. This study also analyzed the content based on seven culture elements. The results of content analysis are found in the 1) linguistic aspect: the alphabets which were used to write the text, knowing the poem, paraphrasing, and translating; 2) literary aspects: the literature genre used were Javanese traditional poems with one matra Dhandhanggula, and 3) cultural aspects: manunggaling kawula Gusti concepts: syariat, tarekat, hakikat, and makrifat which were used as a guidance to know their God.Keywords: Javanese culture, text
PERAN DUKUN TERHADAP PERKEMBANGAN PERADABAN BUDAYA MASYARAKAT JAWA
Authors: Huda M. Dimyati 
Published: February 2020

Perkembangan peradaban manusia sejalan dengan perkembangan zaman yang menuntut suatu perubahan, dan perubahan diidentifikasikan suatu hal yang menjadi lebih baik, nyaman dan mampu menyelesaikan segala persoalan kehidupan. Pada kenyataannya persoalan selalu muncul dari sendi kehidupan baik masalah politik, ekonomi maupun kesehatan. Hal tersebut memicu sebagaian masyarakat yang berusaha menyelesaikan problematika dengan caranya dan alternative yang diambil dengan mendatangi seorang dukun atau paranormal. Sejarah eksistensi dukun dalam masyarakat Jawa tidak terlepas dari lahirnya keyakinan dan kepercayaan yang sudah melekat pada masyarakat sejak nenek moyang hingga berkembangnya peradaban budaya Jawa saat ini dan untuk hal tersebut pada kenyataannya peran dukun terhadap perkembangan peradaban budaya Jawa berpengaruh terhadap kehidupan social masyarakat Jawa.Kata kunci: dukun, Perkembangan Peradaban
GAMELAN SEKATEN DAN PENYEBARAN ISLAM DI JAWA
Authors: Daryanto Joko 
Published: March 2020

Penyebaran Islam di Jawa menggunakan berbagai cara ataupun metode dakwah penyebaran Islam. Salah satu sarana pendukung penyebaran Islam di Pulau Jawa adalah gamelan Sekaten. Perangkat gamelan ini merupakan perangkat gamelan yang dibunyikan untuk memperingati kelahiran Nabi Muhammad SAW, dibunyikan selama satu minggu di Bangsal Pagongan depan Masjid Agung Surakarta.Sebelum orang Jawa mengenal dan memeluk agama Islam, masyarakat Jawa telah memeluk agama Hindu dan Budha. Kondisi sosial psikologis masyarakat Jawa semacam itu rupanya menjadi hambatan para wali untuk menyebarkan agama Islam. Pada akhirnya Sunan Kalijaga mengusulkan agar menggunakan gamelan sebagai daya tarik awal bagi penyebaran agama Islam. Gamelan Sekaten yang digunakan sebagai sarana penyebaran agama Islam di Jawa diduga kuat memiliki nilai-nilai atau unsur-unsur Islam dalam perangkat tersebut.Setting masyarakat Jawa pada saat itu masih memiliki keyakinan yang sangat kuat terhadap agama Hindu dan Budha sehingga diperlukan alat bantu dalam hal ini gamelan Sekaten untuk memudahkan para wali menyebarkan agama Islam. Strategi dakwah dengan menggunakan gamelan Sekaten ternyata sangat menarik dan efektif untuk mengumpulkan orang. Diawali dengan ketertarikan terhadap bunyi gamelan Sekaten akhirnya masyarakat Jawa mengenal dan akhirnya memeluk Islam sebagai keyakinan. ProsesIslamisasi seperti itu selanjutnya disebutsebagai dakwah dengan menggunakan pendekatan kultural.Kata kunci: gamelan, sekaten, Islam, Jawa The spreading of Islamic faith in Java uses many ways or methods to propagate Islamic faith. One of the medium which is support the spreading of Islam in Java is ‘Gamelan Sekaten’. It is kind of an ensemble which is played on the occasion of Muhammad’s birthday and played as long as 1 week in ‘Bangsal Pagongan’ in front of the Great Mosque Surakarta. Before Javanese people knowing and converting into Islamic faith, Javanese people have been converted into Hindu Buddhist faith. This psychological social condition of Javanese people becomes the obstacle for the nine muslim saints, Wali Sanga, to spread Islamic faith. Sunan Kalijaga suggested using ‘gamelan’ as the attractiveness of spreading Islam. The ‘Gamelan Sekaten’ which is used as a medium of spreading Islam in Java strongly assumed that this medium has value or element of Islam. The setting of Javanese people in that time still had a strong faith toward Hindu Buddhist faith, so it required a tool, in this case is a ‘gamelan sekaten’, to facilitate the nine muslim saints in spreading Islamic Faith.This religious proselytizing strategy which is use ‘gamelan sekaten’ as a medium appears to be very interesting effective to gather people. Begins with feel interest to ‘gameln sekaten’, finally, Javanese people know and convert into Islam as their faith. This Islamization process, called as religious proselytizing using cultural approach.Key words: ‘Gamelan Sekaten’. Spreading of Islamic Faith, Cultural Approach
IRAWAN SEBAGAI KORBAN MEDAN PERANG DALAM PERISTIWA KEMATIAN IRAWAN MENURUT SASTRA LAKON TRADISI PEDALANGAN YOGYAKARTA
Authors: Sulanjari Bambang 
Published: February 2020

Naratif Kematian Irawan menurut tradisi pedalangan Yogyakarta telah mengalami “pergeseran” dari induknya: Mahabharata Sansekerta. Menurut tradisi pedalangan Yogyakarta Irawan mati sebelum perang baratayuda dimulai. Naratif kematian Irawan seperti itu, tidak dijumpai dalam Mahabharata Sansekerta maupun kitab-kitab Jawa Kuna.Pergeseran letak naratif kematian Irawan dalam tradisi pedalangan Yogyakarta tersebut, tampaknya bukan hal yang tanpa alasan, karena lakon yang memuat naratif tersebut termasuk Lakon Baratayuda, yaitu lakon yang dikeramatkan dan sangat ketat diwariskan. Untuk memahami kasus ini dilakukan pengkajian tokoh seperti yang pernah dilakukan oleh Alf Hiltebeitel yang berhasil menembus makna Mahabharata melalui pendekatan epik, mite, dan ritual.Peristiwa kematian Irawan dalam tradisi pedalangan Yogyakarta erat kaitannnya dengan Baratayuda. Terbunuhnya Irawan rupanya menyarankan ke arah upacara korban pada tataran ritual. Naratif kematian Irawan tersebut rupanya mengacu pada pemujaan kepada Durga pembunuh Mahisasura. Dengan terlaksananya korban Irawan, maka Pandawa pun memperoleh jaminan kemenangan dalam Baratayuda.Kata kunci: kematian Irawan; tradisi pedalangan Yogyakarta; pendekatan epik, mite dan ritual AbstractThe death of Irawan narrative in the tradition of Yogyakarta puppetry has undergone a "shift" of the origin text: Sanskrit Mahabharata. According to the tradition of Yogyakarta puppetry Irawan die before the Baratayuda war began. Irawan death narrative as such, is not found in the Sanskrit Mahabharata and the books of the Old Javanese.Shifting the narrative the death of Irawan in Yogyakarta puppetry tradition, it seems is not without reason, because the lakon that contains the narrative included Baratayuda lakon, that lakon is sacred and very tight inherited. To understand this case do figures study such ever undertaken by Alf Hiltebeitel who was penetrates the meaning of the Mahabharata through epic, myth, and ritual approach.Irawan death scene in the traditions of Yogyakarta puppetry connected closely with Baratayuda. The kill of Irawan apparently suggested direction sacrifice at the level of ritual approach. The death of Irawan narrative was apparently referring to the cult of Durga Mahisasura killer. With the implementation of Irawan victim, the Pandavas victory was assured in Baratayuda.Key words: the death of Irawan; the tradition of Yogyakarta puppetry; epic, myth, and ritual approach