bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOCKING MOLEKULER SENYAWA 5,5’-DIBROMOMETILSESAMIN
Authors: Pratama Andi Anugrah , Rifai Yusnita , Marzuki Asnah 
Published: December 2020

Docking molekuler merupakan simulasi secara komputasi yang digunakan untuk memprediksi ikatan antara obat/ligan dan reseptor/protein dengan memasangkan suatu molekul kecil (ligan) pada sisi aktif dari reseptor, yang sampai saat ini banyak digunakan dalam proses penemuan dan pengembangan obat baru dengan aktivitas yang lebih baik. Penelitian ini bertujuan untuk melakukan docking molekul dan pemodelan struktur senyawa 5,5’-dibromometilsesamin yang diduga memiliki afinitas terhadap reseptor SMO. Pada penelitian ini, terlebih dahulu dilakukan pemodelan senyawa 5,5’-dibromometilsesamin dan dilakukan optimasi geometri senyawa 5,5’-dibromometilsesamin. Proses docking yang dilakukan melalui tahap preparasi ligan, preparasi reseptor dan simulasi docking. Proses preparasi ligan dilakukan dengan protonasi senyawa 5,5’-dibromometilsesamin. Proses preparasi reseptor dilakukan dengan menghapus molekul air pada reseptor kemudian dilakukan protonasi reseptor. Proses simulasi docking dilakukan setelah proses preparasi ligan dan reseptor telah selesai. Hasil penelitian menunjukkan bahwa molekul 5,5’-dibromometilsesamin memiliki afinitas pada reseptor SMO (kode pdb 4O9R) dengan Docking score yaitu -7.8500 dan residu asam amino yang terikat yaitu Glu518.
MIKROENKAPSULASI ASAM MEFENAMAT MENGGUNAKAN POLIMER HIDROKSI PROPIL METIL SELULOSA DAN NATRIUM ALGINAT DENGAN METODE GELAS IONIK
Authors: Mardikasari Sandra Aulia , Suryani Suryani , Akib Nur Illiyyin , Sahumena Muhammad Handoyo , Hastuti Sri , Putri Suci Ananda 
Published: December 2020

Asam mefenamat bersifat rentan terhadap cahaya maupun terhadap udara dan kelembaban. Selain itu asam mefenamat memiliki waktu paruh yang sempit, dapat menyebabkan peningkatan resiko gangguan gastrointestinal termasuk iritasi lambung pada penggunaan jangka panjang. Teknologi Mikroenkapsulasi merupakan proses penyalutan bahan aktif berupa cairan ataupun padatan dengan lapisan yang relatif tipis dengan ukuran partikel yang sangat kecil antara 0,2-5000 μm. Tujuan penelitian ini untuk melakukan preparasi mikroenkapsulasi terhadap asam mefenamat menggunakan polimer Hidroksi Propil Metil Selulosa (HPMC) dan Natrium alginat dengan metode gelasi ionik lalu mengkarakterisasi hasil mikrokapsul yang diperoleh. Preparasi mikroenkapsulasi dilakukan dengan membandingkan konsentrasi polimer yang digunakan, dibuat dalam 3 formula. Parameter karakterisasi meliputi penetapan efisiensi penjerapan, distribusi ukuran partikel, bentuk partikel dan pengujian disolusi. Hasil karakterisasi menujukan mikroenkapsulasi Asam Mefenamat yang dihasilkan memiliki bentuk partikel yang spheris, dengan nilai efisiensi penjerapan terbesar yaitu 67,53% untuk perbandingan HPMC dan natrium alginat masing-masing 4 : 1, sedangkan distribusi ukuran partikel bervariasi dengan ukuran terkecil yakni 1.105 , untuk hasil pengujian disolusi pada medium asam diperoleh konsentrasi pelepasan obat terbesar adalah 10,39 mg/L dan medium basa sebesar 74,456mg/mL. Penelitian Hasil penelitian ini menunjukkan bahwa asam mefenamat dapat dipreparasi dengan teknik mikroenkapsulasi sehingga dapat mengatasi beberapa kekurangan asam mefenamat.
ANALISIS RESIDU PESTISIDA KLORPIRIFOS PADA CABAI (Capsicum sp.) DARI DESA BUNGIN KECAMATAN BUNGIN KABUPATEN ENREKANG
Authors: Damaiyanti Damaiyanti , Yulianty Risfah , Marzuki Asnah , Kasim Syaharuddin , Rante Herlina 
Published: December 2020

Cabai merupakan salah satu komoditas yang berkontribusi besar pada inflasi di Indonesia. Produksi cabai sering mengalami serangan hama dan penyakit yang merupakan salah satu penyebab utama kegagalan panen. Akibat dari serangan hama tersebut dapat mencapai kerugian sebesar 40-50%. Kerugin tersebut menyebabkan petani tidak mau mengambil resiko dan menempuh jalan yang singkat yaitu denga penggunaan pestisida kimia secara berlebihan yang secara tidak langsung dapat meninggalkan residu pestisida. Tujuan dari penelitian ini adalah untuk mengetahui kadar residu pestisida klorpirifos dan propenofos yang terdapat dalam cabai. Sampel diambil dari desa Bungin kecamatan Bungin kabupaten Enrekang dan diekstraksi menggunakan metode QuEChERS dan dianalisis dengan alat GC/MS, sehingga diperoleh hasil bahwa cabai merah, cabai keriting dan cabai rawit mengandung pestisida dengan bahan aktif klorfirifos yang ditandai dengan munculnya peak pada menit ke 6 dengan base 314 m/z, dan konsetrasi masing-masing 0,0312; 0,0311; dan 0,0627 ppm; namun masih aman untuk di konsumsi karena masih di bawah batas maksimum residu yang di perbolehkan yaitu 20 ppm untuk pestisida klorpirifos.
IDENTIFIKASI DAN PENENTUAN KADAR KATEKIN DARI SEDUHAN DAN EKTRAK ETANOL PRODUK TEH HIJAU (Camelia sinensi L) KOMERSIAL SECARA SPEKTROFOTOMETRI UV-VISIBLE
Authors: Nur Syamsu 
Published: December 2020

Teh hijau merupakan salah satu jenis minuman kesehatan yang mengandung golongan senyawa polifenol dan memiliki banyak manfaat. Jenis senyawa polifenol yang banyak ditemukan pada teh hijau adalah kandungan katekin. Pada penelitian ini telah dikaji kandungan senyawa katekin dari produk teh hijau kemasan yang merupakan produk komersial dari Indonesia (A), Thailand (B) dan Jepang (C). Teh hijau kemasan diekstraksi dengan cara diseduh pada suhu dan waktu yang berbeda serta ekstraksi dengan cara maserasi menggunakan pelarut etanol 70%. Identifikasi kandungan katekin dilakukan menggunakan reagen kimia dan spektrofotometer UV-Vis serta penentuan kadarnya dilakukan secara spektrofotometri UV-Vis. Hasil yang diperoleh menunjukkan bahwa teh hijau mengandung senyawa epigallocatechin-3-gallate (EGCG) sesuai dengan adanya perubahan warna berdasarkan reagen kimia dan spektrum UV yang memiliki λmax pada kisaran 270-274 nm. Hasil uji kuantitatif secara spektrofotometri UV-Vis menunjukkan bahwa ekstraksi dengan cara penyeduhan pada teh hijau B memiliki kadar katekin tertinggi yang diikuti berturut-turut pada sampel A dan C. Sedangkan kadar katekin dari hasil maserasi menggunakan etanol 70% pada teh hijau A memiliki kadar katekin tertinggi diikuti teh hijau C dan B.
PEMODELAN MOLEKUL SENYAWA TURUNAN KOJIC ACID SERTA INTERAKSINYA DENGAN ENZIM TIROSINASE
Authors: Permadi Fazrul 
Published: December 2020

Studi HKSA dilakukan pada turunan kojyl thioether sebagai inhibitor tirosinase. Perhitungan prediktotr dilakukan menggunakan aplikasi hyperchem 8.0 dengan metode optimasi geometri semi-empirik PM3. Analisis regresi multilinier menggunakan SPSS 25.0 untuk mencari hubungan antara prediktor dan aktivitas senyawa turunan kojyl thioether sebagai inhibitor tirosinase. Model persamaan HKSA terbaik adalah :pIC50 = -922.517 + 15.872*ELUMO – 436.654*qC4 – 209.509*qC5 + 1.0008*Eintn = 14; m = 4; r = 0.949; R2 = 0.901; PRESS = 3.0469; q2 = 0.8246Berdasarkan persamaan HKSA diatas didapatkan 4 senyawa baru turunun kojyl thioether yang bisa dijadikan sebagai analog inhibitor tirosinase yang baru. Parameter pemilihan senyawa tersebut karena memiliki aktivitas yang lebih baik sebagai inhibitor tirosinase dibandingkan senyawa penuntun, tidak hepatotoksik, tidak menimbulkan AMES Toxicity, tidak menimbulkan skin sensititasion dan LD50 pada tikus masuk kategori relative tidak membahayakan. Untuk melihat interaksi antara senyawa turunun kojyl thioether dengan enzim tirosinase dilakukan docking menggunakan Autodock vina yang visualisasinya menggunakan discovery studio 2020 client. Hasil docking menunjukkan bahwa semua senyawa setidaknya memiliki satu interaksi pada residu asam amino yang sama dengan native ligan. yaitu Val283.
Reconstruction of Quadriceps Muscle Function Using the Latissimus Dorsi Muscle Transfer in an Elderly Patient
Authors: Huayllani Maria T. , Boczar Daniel , Murray Peter M. , Sherman Courtney E. , Wilke Benjamin K. , Forte Antonio J. 
Published: December 2020

Case:
We report a case of a 71-year-old man diagnosed with high-grade undifferentiated pleomorphic sarcoma in the left thigh. He underwent partial resection of the quadriceps and proximal femoral bone, followed by reconstruction with a latissimus dorsi free muscle flap through end-to-end vascular and nerve anastomosis with the femoral vessels and a branch of the femoral nerve, respectively. Recovery of 3/5 knee extension function was achieved 3 months postsurgery without complications.

Conclusion:
Free neurotized latissimus dorsi muscle transfer is a successful reconstructive option to restore knee extension after quadriceps resection.

Level of Evidence:
Level IV.
Infectious Brachial Plexopathy and Septic Arthritis of the Shoulder due to Lemierre's Syndrome
Authors: Gusnowski Eva M. , Morrison Laura J. , Bois Aaron J. 
Published: December 2020

Case:
We present a 20-year-old female with Lemierre's syndrome and an associated infectious brachial plexopathy and missed septic shoulder arthritis. She subsequently presented with advanced post-infectious glenohumeral joint arthritis. At the final 12-month follow-up, substantial shoulder pain and dysfunction persisted.

Conclusions:
When Lemierre's syndrome has been diagnosed, patients with upper extremity symptoms suggestive of metastatic infection require a thorough assessment to rule out musculoskeletal involvement and site-specific intervention to prevent long-term morbidity.
Prevalence and factors associated to contamination from porcine epidemic diarrhea virus during the transportation of pigs to slaughterhouses in Colombia
Authors: Ortiz Maria del Pilar Pineda , Morales Johanna Paola Corrales , Herrera Gilma Hernández , Pena Carlos Enrique Trillos , Moreno Diana Corina Zambrano 
Published: December 2020

Abstract
Porcine epidemic diarrhea virus (PEDV) causes acute diarrhea, dehydration, and high mortality in newborn piglets and has caused high economic impact in the swine industry in the United States and Asia. Until March 2014, PED was an exotic disease in Colombia. This study was carried out at the beginning of the spread of PEDV in the country, and its main objective was to determine the prevalence and factors associated to the contamination of PEDV in the transportation of pigs to the slaughterhouses in Colombia through environmental samples analyzed by RT-PCR. 518 pig trucks in the 32 main slaughterhouses, were sampled and the drivers of the trucks fulfilled a questionnaire. The prevalence of PEDV at the entrance of the slaughterhouses was 71.8% (CI 95%: 70.8-72.8) versus 70.5% (CI 95%: 69.5-71.5) at the slaughterhouse exit, and there was no evidence of significant differences between both rates. (McNemar value p: 0.375). The factors that increased the possibility of truck contamination were: vehicles that visit national slaughterhouses (OR 15.9 95% CI: 4.9–51.85) and that visit national –export type (OR 9.0 95% CI: 2.20–36.91), trucks with mobility in area of ​​greatest slaughter (OR 9.05 95% CI: 2.9-27.63), the non-exclusive use of vehicles to transport pigs (OR 3.75 95% CI: 1.55-9.08) and visit animal feed mills (OR 13.5 95% CI: 4.1– 44.12). The factors identified that reduce the possibility of contamination were cleanliness of the body truck (OR 0.089 95% CI: 0.03-0.23) and the cabin (OR 0.16 95%CI: 0.08-0.31), use of disinfectant (OR 0.32 95% CI:0.16-0.62), pressurized water (OR 0.38 95% CI:0.15-0.95), and back pump (OR 0.17 95% CI:0.08-0.35) and the exclusive use of the vehicle for pig transportation (OR 0.36 95% CI: 0.19-0.70). The results showed that the high grade of mobilization of the trucks to points of concentration, failures in biosecurity and virus survival characteristics, enabled the spread of PEDV, turning it into an endemic disease in Colombia; however, the measures implemented by the farmers mitigated the impact of the disease. We evidenced the need of standardizing and regulating biosecurity protocols for slaughterhouses, pig transportation and farms.
Cortical Bone Model With a Microcrack Under Tensile Loading
Authors: Wang Xu , Wang Wenshuai , Ding Shenghu , Chen Yaogeng , Li Xing 
Published: December 2020

Abstract
BackgroundBone is a biological material whose mechanical properties are outstanding. The fracture mechanics research of cortical bone is a major challenge to fully understand the complex behavior of biological composites and for the design of future bioinspired materials. MethodsIn order to characterize the fracture mechanics behavior of cortical bone, the plane problem for the cortical bone with a microcrack located in the interstitial tissue under tensile loading was considered. Using the solution for the continuously distributed edge dislocations as Green's functions, the problem was formulated. ResultsThe singular integral equations with Cauchy kernels were obtained. And the numerical results indicate that the stress intensity factor of the microcrack is dominated by the material constants and the geometric parameters of the cortical bone.ConclusionThe numerical results suggest that a soft osteon promotes the microcrack propagation while stiff one repels it, but this interaction effect is limited near the osteon. Some of the numerical results are in accordance with the results obtained and additional numerical results predicted need to be confirmed.
Intra-Arterial Transplantation of Stem Cells in Large Animals – A Minimally-Invasive Strategy for the Treatment of Disseminated Neurodegeneration
Authors: Malysz-Cymborska Izabela , Golubczyk Dominika , Kalkowski Lukasz , Kwiatkowska Joanna , Zawadzki Michal , Glodek Joanna , Holak Piotr , Sanford Joanna , Milewska Kamila , Adamiak Zbigniew , Walczak Piotr , Janowski Miroslaw 
Published: December 2020

Abstract
Stem cell transplantation proved promising in animal models of neurological diseases; however, in conditions with disseminated pathology such as ALS, delivery of cells and their broad distribution is challenging. To address this problem, we explored intra-arterial (IA) delivery route of stem cells. The goal of this study was to investigate the feasibility and safety of MRI-guided transplantation of glial restricted precursors (GRPs) and mesenchymal stem cells (MSCs) in dogs suffering from ALS-like disease, degenerative myelopathy (DM). Three naïve pigs were used for MSC transplantation as a pre-treatment control before transplantation in dogs. Cells were labeled with iron oxide nanoparticles. For IA transplantation a 1.2-French microcatheter was advanced into the middle cerebral artery under roadmap guidance. Then, the cells were transplanted under real-time MRI with the acquisition of dynamic T2*-weighted images. Interventional and follow-up MRI proved the procedure was feasible and safe. The transplantation of canine GRPs resulted in rather poor retention in the brain, whereas canine MSCs demonstrated excellent settlement. Notably, histopathology showed the successful and predictable placement of transplanted porcine MSCs. Analysis of gene expression after transplantation revealed a reduction of inflammatory factors, which may indicate a promising therapeutic strategy in the treatment of neurodegenerative diseases.
Feet Plantar Pressure Distribution Among Female School Teachers
Authors: Alias Ayuni Nabilah , Karuppiah Karmegam , How Vivien , Perumal Velu 
Published: December 2020

Abstract
Background: Plantar pressure distribution has been recognized as a significant finding to associate with various feet conditions. Objectives: To determine the feet plantar pressure distribution among female school teachers; Methods: This research consisted of 124 female school teachers. Respondents was asked to walk at a regular pace for 10 seconds from a fixed starting point while using footwear pressure insole device and pressure measurement was recorded.; Results: The findings show that lateral heel exerted the most pressure in the right and left foot (94 kPa vs 85 kPa). The second highest average of plantar pressure distribution for right foot among female school teachers was medial forefoot (67 kPa), followed by central forefoot (55 kPa), lateral forefoot (52 kPa) and lateral midfoot with 49 kPa. For the left foot, the second highest for average of plantar pressure distribution was medial forefoot (58 kPa), followed by lateral forefoot (48 kPa), and central forefoot (47 kPa) and lateral midfoot (33 kPa). The result was significant differences as the right foot often exerted greater pressure on any part of the foot than the left foot; Conclusions: The pressure plantar distribution of foot reflects the conditions of school teachers with various posture and movement.
Eating Behaviour, Physical Activity, TV Exposure and Sleeping Habits in Five Year Olds: A Latent Class Analysis
Authors: Mattsson Molly , Murray Deirdre , Kiely Mairead , McCarthy Fergus , McCarthy Elaine , Biesma Regien , Boland Fiona 
Published: December 2020

Abstract
Background Diet, physical activity, sedentary behaviours, and sleep time are considered major contributory factors of the increased prevalence of childhood overweight and obesity. The aim of this study was to identify behavioural clusters of five year old children based on lifestyle behaviours, their association with sociodemographic and maternal characteristics and early feeding practices, and to determine if class membership was associated with cardio metabolic outcomes. Methods Latent class analysis of eating behaviour, engagement in active play, TV watching, and sleep duration in 1,229 five year old children from the Cork BASELINE birth cohort study was used to identify behavioral clusters. Determinants of cluster membership were investigated using multinomial logistic regression. Associations between the identified classes and cardio body measures were examined using multivariate logistic and linear regression, with cluster membership used as the independent variable.Results 51% of children belonged to a normative class, while 28% of children were in a class characterised by high scores on food avoidance scales in combination with low enjoyment of food, and 20% experienced high scores on the food approach scales. Children in both these classes had lower conditional probabilities of engaging in active play for at least one hour per day and sleeping for a minimum of 10 hours, and higher probability of watching TV for two hours or more, compared to the normative class. Children in the class with high scores on food approach scales, had higher fat mass index (FMI), lean mass index (LMI), and waist-to-height ratio (WtHR) compared to the normative class, and were at greater risk of overweight and obesity.Conclusion Findings suggest that eating behaviour appeared to influence overweight and obesity risk to a greater degree than activity levels at five years old. Further research of how potentially obesogenic behaviours in early life track over time and influence adiposity and other cardio metabolic outcomes is crucial to inform the timing of interventions.
Possibilities of Using Physical Modeling With Soft Materials to Analyze and Optimize Metal Forming Processes
Authors: Hawryluk Marek , Suliga Maciej , Więclaw Mateusz 
Published: December 2020

Abstract
The study presents the concept of physical modelling together with the characterization of the modelling materials as well as the possibilities of applying this type of physical simulation methods for the analysis, design and optimization of industrial metal forming processes. The paper discusses the crucial similarity conditions between the physical model and the real process necessary to transform the results into industrial processes. Physical modelling is one of the most popular as well as cheapest methods of analyzing metal plastic forming processes and it can constitute an easy independent verifying tool. It can also be a competitive alternative or supplementation, or a quick verification, of the popular yet relatively expensive methods based on a broadly understood mathematical apparatus, e.g. the finite element method or various types of computer science techniques. The method provides the possibility to define the stress and deformation distribution, estimate the force parameters of the given process as well as localize the dead zones and material flow errors. On the example of a forward extrusion process, the study demonstrates the effect of matching the model material to two metallic materials: annealed aluminum and reinforced aluminum. Additionally, for reinforced aluminum, numerical modelling was performed, which made it possible to determine e.g.: the force parameters and the material flow manner. Next, based on physical modelling, verification through numerical modelling was made of the boundary and tribological conditions, as physical modelling revealed a so-called dead zone in the corner of the die, which had not been recorded in numerical modelling.
Predicting Fetal Distress and Admission to Neonatal Intensive Care Unit in Patients With Fetal Growth Restriction by Nomogram: A Retrospective Cohort Study in China
Authors: Chen Xiaobin , Chen Yuan , Jiang Ying , Dong Tian , Li Juan , Yang Mengmeng , Zhao Baihui , Luo Qiong 
Published: December 2020

Abstract
Background: The purpose of this research was to establish prediction model of fetal distress risk and admission to neonatal intensive care unit(NICU) risk in a Chinese population of patients with fetal growth restriction(FGR), to provide a reliable basis for clinical management. Methods: A retrospective analysis of 930 patients were delivered with FGR in the obstetrics and gynecology hospital affiliated from January 1, 2014 to December 30, 2019 at Women’s Hospital, School of Medicine, Zhejiang University, in Hangzhou, and screened out the independent predictors affecting fetal distress and admission to NICU using lasso regression. Multivariable logistic regression analysis was used to establish the nomogram prediction model of fetal distress risk and admission to NICU risk. Discrimination of the predicting model was assessed by the C-index and receiver operating characteristic (ROC) curve, using the bootstrapping validation and the ROC curve to evaluate the Internal validation. Calibration and clinical usability of the predicting model were respectively adopted by calibration curves and decision curve analysis. Internal validation was assessed using the bootstrapping validation. Results: We found that six identified factors associated with fetal distress of patients with FGR: age, gestational week, delivery method, placenta previa, abnormal cord blood flow, and using low molecular weight heparin(LMWH). The application of LMWH during pregnancy could reduce the incidence of fetal distress. Four independent predictors were selected for admission to NICU of patients with FGR: gestational week, delivery method, hypertensive disorders of pregnancy, and intrahepatic cholestasis of pregnancy. The delivery method of cesarean section increased the above risks. Two nomograms were developed and verified accordingly. The two models had good discrimination and good calibration respectively. The decision curve analysis performed that the clinical usability and benefits of the nomograms were the range of 3%-75% and 17%-95%. Conclusions: Two nomograms were the first to predict fetal distress and admission to NICU of patients with FGR. Establishing effective predictive models based on independent predictors could help early diagnosis and evaluation of fetal distress and admission to NICU in patients with FGR.