bluuebunny/crossref_metadata_2025_split huggingface dataset:
Things left unsaid: important topics that are not discussed between patients with systemic sclerosis, their carers and their healthcare professionals—a discourse analysis
Authors: Denton Christopher P. , Laird Bee , Moros Lizette , Luna Flores Jose Luis 
Published: September 2020

Abstract
Introduction
Systemic sclerosis (SSc) is a rare condition that can be complicated by interstitial lung fibrosis (SSc-ILD)—a major cause of mortality. This study explored information and communication needs of patients with SSc-ILD and their carers to understand what they are and whether they are met.

Methods
Qualitative research was performed, including in-depth individual interviews and observed conversations between pairs of patients, physicians and nurses, and between patients and physicians discussing experiences of SSc-ILD. The study was performed in Germany, Italy, Spain, the UK and the USA. Participants included 42 SSc-treating physicians, 21 patients with diagnosed SSc-ILD, 16 specialist nurses and five carers.

Results
Prognosis and mortality were the main unspoken topics acknowledged by patients, carers and healthcare professionals. Patients and carers felt afraid to ask physicians about mortality, and most physicians reported avoiding the question because their duty was to give patients hope and avoid causing additional distress. Patients often felt unable to ask physicians about relationships, family and work because of time constraints or because they felt these were not topics physicians would be concerned about. Often, specialist nurses felt that they had insufficient knowledge to provide adequate support.

Conclusion
Key topics, including mortality and prognosis, are rarely openly discussed, leaving patients uncertain and anxious about the future. By communicating about difficult but important topics, physicians and nurses could help patients and carers manage and plan their lives. This study shows that a multi-professional team-based communication approach is likely to better address patient needs and priorities.

Key Points

• Key topics in SSc or SSc-ILD, such as mortality and prognosis, are rarely openly discussed in clinical consultations.
• By communicating difficult but important topics, physicians and nurses could help patients manage their disease and plan their lives.
• A multi-professional team-based communication approach is likely to better address patient needs and priorities and could be easily implemented without the need for significant additional resources.
Weak swimming response of a bdelloid rotifer to chemical cues of a native copepod predator
Authors: Parysek Marta , Pietrzak Barbara 
Published: September 2020

AbstractWhether bdelloid rotifers can detect and respond to the chemical cues of predators has not been studied, and research on their behaviour is scarce in general. To test for such response, we observed the behaviour of Philodina megalotrocha rotifers in either control or copepod-conditioned water. We then introduced a mechanical disturbance to test if predator odour sensitises rotifers to subsequent cues. We found intensified swimming in P. megalotrocha exposed to Macrocyclops fuscus-conditioned water, i.e. the larger and more predatory of the tested copepods. Such response may be adaptive, depending on the predominant hunting mode of the predator in the particular habitat.
A reference high-pressure CH4 adsorption isotherm for zeolite Y: results of an interlaboratory study
Authors: Nguyen H. G. T. , Sims C. M. , Toman B. , Horn J. , van Zee R. D. , Thommes M. , Ahmad R. , Denayer J. F. M. , Baron G. V. , Napolitano E. , Bielewski M. , Mangano E. , Brandani S. , Broom D. P. , Benham M. J. , Dailly A. , Dreisbach F. , Edubilli S. , Gumma S. , Möllmer J. , Lange M. , Tian M. , Mays T. J. , Shigeoka T. , Yamakita S. , Hakuman M. , Nakada Y. , Nakai K. , Hwang J. , Pini R. , Jiang H. , Ebner A. D. , Nicholson M. A. , Ritter J. A. , Farrando-Pérez J. , Cuadrado-Collados C. , Silvestre-Albero J. , Tampaxis C. , Steriotis T. , Řimnáčová D. , Švábová M. , Vorokhta M. , Wang H. , Bovens E. , Heymans N. , De Weireld G. 
Published: September 2020

AbstractThis paper reports the results of an international interlaboratory study led by the National Institute of Standards and Technology (NIST) on the measurement of high-pressure surface excess methane adsorption isotherms on NIST Reference Material RM 8850 (Zeolite Y), at 25 °C up to 7.5 MPa. Twenty laboratories participated in the study and contributed over one-hundred adsorption isotherms of methane on Zeolite Y. From these data, an empirical reference equation was determined, along with a 95% uncertainty interval (Uk=2). By requiring participants to replicate a high-pressure reference isotherm for carbon dioxide adsorption on NIST Reference Material RM 8852 (ZSM-5), this interlaboratory study also demonstrated the usefulness of reference isotherms in evaluating the performance of high-pressure adsorption experiments.
Kinetics of liquid phase batch adsorption experiments
Authors: Brandani Stefano 
Published: September 2020

AbstractBatch adsorption experiments are carried out by adding a known amount of adsorbent to a liquid solution at a known initial concentration and following the evolution in time of the concentration of the adsorbate. This is a very common method to obtain equilibrium and kinetic information in liquid systems, but in most cases kinetic results are analysed on the basis of empirical models. Two phenomenological models based on macropore diffusion in beads and shrinking core kinetics are used to generate data that are then interpreted with the widely used unconstrained linear regression methods. The results show that for both cases R2 values close to unity are obtained leading to the incorrect interpretation of the mechanism of mass transport. It is recommended that batch adsorption experiments should be analysed using phenomenological models to obtain physical parameters that are applicable to other systems and to reduce the experiments required to characterise fully the kinetics of adsorption.
Behaviourism in Disguise: The Triviality of Ramsey Sentence Functionalism
Authors: Lowther T. S. 
Published: September 2020

AbstractFunctionalism has become one of the predominant theories in the philosophy of mind, with its many merits supposedly including its capacity for precise formulation. The most common method to express this precise formulation is by means of the modified Ramsey sentence. In this article, I will apply work from the field of the philosophy of science to functionalism for the first time, examining how Newman’s objection undermines the Ramsey sentence as a means of formalising functionalism. I will also present a formal variation on Newman’s objection through mathematical induction. Together, these proofs suggest that functionalism formalised by the Ramsey sentence trivially reduces to a kind of behaviourism plus a cardinality constraint on the number of relations holding between mental-relevant behaviours. As most functionalists see functionalism as a distinct theory of mind from behaviourism, this suggests that the modified Ramsey sentence cannot form a satisfactory formalism for functionalism.
Impact of technostress on academic productivity of university students
Authors: Upadhyaya Pallavi , Vrinda  
Published: September 2020

AbstractThere has been increasing interest among researchers to understand the negative effects of technology, in the last two decades. Technostress or stress induced due to technology is extensively reported in the literature, among working professionals. Even though there has been an increased proliferation of digital devices in academia, there is a dearth of studies examining the prevalence of technostress and its impact among students. This study examines the prevalence of technostress among the younger population, in the age group of 18–28 years. Using a sample of 673 Indian private university students, this study cross-validated the technostress instrument. Increased use of technology in higher education has compelled students to complete all their academic work, including assessments, using technology. Technology-enhanced learning applications such as learning management systems, MOOCs and digital exam devices require students to develop ICT skills. The study also investigates the impact of technostress on the academic productivity of students. Findings reveal that the technostress instrument is valid to be used in the academic context, with minor modifications, and students experienced moderate levels of technostress. It was also found that technostress had a negative impact on the academic productivity of students.
Treatment of environmental contamination using sepiolite: current approaches and future potential
Authors: Song Na , Hursthouse Andrew , McLellan Iain , Wang Zhenghua 
Published: September 2020

AbstractTo evaluate the potential of sepiolite-based materials to resolve environmental pollution problems, a study is needed which looks at the whole life cycle of material application, including the residual value of material classified as waste from the exploitation of sepiolite deposits in the region or from its processing and purification. This would also maximize value from the exploitation process and provide new potential for local waste management. We review the geographical distribution of sepiolite, its application in the treatment of potentially toxic elements in soil and across the wider landscape, an assessment of modification and compositional variation of sepiolite-based applications within site remediation and wastewater treatment. The potential of sepiolite-based technologies is widespread and a number of processes utilize sepiolite-derived materials. Along with its intrinsic characteristics, both the long-term durability and the cost-effectiveness of the application need to be considered, making it possible to design ready-to-use products with good market acceptance. From a critical analysis of the literature, the most frequently associated terms associated with sepiolite powder are the use of lime and bentonite, while fly ash ranked in the top ten of the most frequently used material with sepiolite. These add improved performance for the inclusion as a soil or wastewater treatment options, alone or applied in combination with other treatment methods. This approach needs an integrated assessment to establish economic viability and environmental performance. Applications are not commonly evaluated from a cost–benefit perspective, in particular in relation to case studies within geographical regions hosting primary sepiolite deposits and wastes that have the potential for beneficial reuse.
APOL1 polymorphism modulates sphingolipid profile of human podocytes
Authors: Valsecchi Manuela , Cazzetta Valentina , Oriolo Ferdinando , Lan Xiqian , Piazza Rocco , Saleem Moin A. , Singhal Pravin C. , Mavilio Domenico , Mikulak Joanna , Aureli Massimo 
Published: September 2020

AbstractApolipoprotein L1 (APOL1) wild type (G0) plays a role in the metabolism of sphingolipids, glycosphingolipids, sphingomyelin and ceramide, which constitute bioactive components of the lipid rafts (DRM). We asked whether APOL1 variants (APOL1-Vs) G1 and G2 carry the potential to alter the metabolism of sphingolipids in human podocytes. The sphingolipid pattern in HPs overexpressing either APOL1G0 or APOL1-Vs was analysed by using a thin mono- and bi-dimensional layer chromatography, mass-spectrometry and metabolic labelling with [1-3H]sphingosine. HP G0 and G1/G2-Vs exhibit a comparable decrease in lactosylceramide and an increase in the globotriaosylceramide content. An analysis of the main glycohydrolases activity involved in glycosphingolipid catabolism showed an overall decrease in the activeness of the tested enzymes, irrespective of the type of APOL1-Vs expression. Similarly, the high throughput cell live-based assay showed a comparable increased action of the plasma membrane glycosphingolipid-glycohydrolases in living cells independent of the genetic APOL1 expression profile. Importantly, the most significative modification of the sphingolipid pattern induced by APOL1-Vs occurred in DRM resulted with a drastic reduction of radioactivity associated with sphingolipids. G1/G2-Vs present a decrease amount of globotriaosylceramide and globopentaosylceramide compared to G0. Additionally, ceramide at the DRM site and lactosylceramide in general, showed a greatest fall in G1/G2 in comparison with G0. Additionally, the levels of glucosylceramide decreased only in the DRM of human podocytes overexpressing G1/G2-Vs. These findings suggest that altered sphingolipidsprofiles may contribute to the deranged functionality of the plasma membrane in APOL1 risk milieu.
Glaucoma patients have an increased level of trimethylamine, a toxic product of gut bacteria, in the aqueous humor: a pilot study
Authors: Skrzypecki Janusz , Izdebska J. , Kamińska A. , Badowska J. , Przybek-Skrzypecka J. , Bombuy J. , Samborowska E. , Szaflik J. P. 
Published: September 2020

Abstract
Purpose
Animal studies suggest that gut bacteria metabolites are involved in regulation of intraocular pressure or development of glaucoma. However, clinical data are lacking. Here, we wanted to compare level of trimethylamine (TMA), an uremic toxin produced by gut bacteria, along with betaine and trimethylamine N-oxide (TMAO), a substrate and a product of its metabolism, in the aqueous humor and in plasma of patients with glaucoma and their controls.

Methods
Twenty patients were selected for cataract phacoemulsification, and 20 patients selected for phacotrabeculectomy were enrolled in the study. Patients were matched with controls on systemic diseases and estimated glomerular filtration rate. Blood samples were collected in the preoperative suite, whereas aqueous humor samples were collected as the first step of both procedures. Subsequently, level of betaine, TMA and TMAO was analyzed by means of chromatography.

Results
In the aqueous humor, level of TMA, but not betaine or TMAO, was significantly higher in the phacotrabeculectomy group than in the phacoemulsification group. Plasma level of betaine, TMA and TMAO was similar between groups. In both groups, level of betaine and TMA, but not TMAO, was significantly higher in plasma than in the aqueous humor.

Conclusion
TMA, but not TMAO or betaine level, is increased in the aqueous humor of patients with glaucoma. TMA might play a role in pathogenesis of glaucoma; however, prospective studies are needed to confirm our findings.
Agrarian Vision, Industrial Vision, and Rent-Seeking: A Viewpoint
Authors: Jauernig Johanna , Pies Ingo , Thompson Paul B. , Valentinov Vladislav 
Published: September 2020

AbstractMany public debates about the societal significance and impact of agriculture are usefully framed by Paul Thompson’s distinction between the “agrarian” and the “industrial vision.” The key argument of the present paper is that the ongoing debate between these visions goes beyond academic philosophy and has direct effects on the political economy of agriculture by influencing the scope of rent-seeking activities that are undertaken primarily in the name of the agrarian vision. The existence of rent-seeking activities is shown to reflect the fact that the agrarian vision is not universally supported, which is certainly true of the industrial vision as well. The key argument of the present paper is that these two philosophical visions of agriculture are not radically incongruent. Rather, they share a common ground within which they are even mutually supportive. If agricultural policy making is oriented toward this common ground, it may reduce overall dissatisfaction with the resulting institutional regime of agricultural production. Such an agricultural policy may also stimulate the emergence of new business practices that not only enable efficient agricultural production but also minimize negative ecological impact and preserve cultural landscapes.
Studying the Composition and Mineralogy of the Hermean Surface with the Mercury Radiometer and Thermal Infrared Spectrometer (MERTIS) for the BepiColombo Mission: An Update
Authors: Hiesinger H. , Helbert J. , Alemanno G. , Bauch K. E. , D’Amore M. , Maturilli A. , Morlok A. , Reitze M. P. , Stangarone C. , Stojic A. N. , Varatharajan I. , Weber I. ,   the MERTIS Co-I Team
Published: September 2020

AbstractLaunched onboard the BepiColombo Mercury Planetary Orbiter (MPO) in October 2018, the Mercury Radiometer and Thermal Infrared Spectrometer (MERTIS) is on its way to planet Mercury. MERTIS consists of a push-broom IR-spectrometer (TIS) and a radiometer (TIR), which operate in the wavelength regions of 7-14 μm and 7-40 μm, respectively. This wavelength region is characterized by several diagnostic spectral signatures: the Christiansen feature (CF), Reststrahlen bands (RB), and the Transparency feature (TF), which will allow us to identify and map rock-forming silicates, sulfides as well as other minerals. Thus, the instrument is particularly well-suited to study the mineralogy and composition of the hermean surface at a spatial resolution of about 500 m globally and better than 500 m for approximately 5-10% of the surface. The instrument is fully functional onboard the BepiColombo spacecraft and exceeds all requirements (e.g., mass, power, performance). To prepare for the science phase at Mercury, the team developed an innovative operations plan to maximize the scientific output while at the same time saving spacecraft resources (e.g., data downlink). The upcoming fly-bys will be excellent opportunities to further test and adapt our software and operational procedures. In summary, the team is undertaking action at multiple levels, including performing a comprehensive suite of spectroscopic measurements in our laboratories on relevant analog materials, performing extensive spectral modeling, examining space weathering effects, and modeling the thermal behavior of the hermean surface.
Revision of Coelastrella (Scenedesmaceae, Chlorophyta) and first register of this green coccoid microalga for continental Norway
Authors: Goecke F. , Noda J. , Paliocha M. , Gislerød H. R. 
Published: September 2020

Abstract
A terrestrial green microalga was isolated at Ås, in Akershus County, Norway. The strain corresponded to a coccoid chlorophyte. Morphological characteristics by light and electron microscopy, in conjunction with DNA amplification and sequencing of the 18 s rDNA gene and ITS sequences, were used to identify the microalgae. The characteristics agree with those of the genus Coelastrella defined by Chodat, and formed a sister group with the recently described C. thermophila var. globulina. Coelastrella is a relatively small numbered genus that has not been observed in continental Norway before; there are no previous cultures available in collections of Norwegian strains. Gas chromatography analyses of the FAME-derivatives showed a high percentage of polyunsaturated fatty acids (44–45%) especially linolenic acid (C18:3n3; 30–34%). After the stationary phase, the cultures were able to accumulate several carotenoids as neoxanthin, pheophytin a, astaxanthin, canthaxanthin, lutein, and violaxanthin. Due to the scarcity of visual characters suitable for diagnostic purposes and the lack of DNA sequence information, there is a high possibility that species of this genus have been neglected in local environmental studies, even though it showed interesting properties for algal biotechnology.
MetaboShiny: interactive analysis and metabolite annotation of mass spectrometry-based metabolomics data
Authors: Wolthuis Joanna C. , Magnusdottir Stefania , Pras-Raves Mia , Moshiri Maryam , Jans Judith J. M. , Burgering Boudewijn , van Mil Saskia , de Ridder Jeroen 
Published: September 2020

AbstractDirect infusion untargeted mass spectrometry-based metabolomics allows for rapid insight into a sample’s metabolic activity. However, analysis is often complicated by the large array of detected m/z values and the difficulty to prioritize important m/z and simultaneously annotate their putative identities. To address this challenge, we developed MetaboShiny, a novel R/RShiny-based metabolomics package featuring data analysis, database- and formula-prediction-based annotation and visualization. To demonstrate this, we reproduce and further explore a MetaboLights metabolomics bioinformatics study on lung cancer patient urine samples. MetaboShiny enables rapid and rigorous analysis and interpretation of direct infusion untargeted mass spectrometry-based metabolomics data.
Comparing the incomparable? A review of methodical aspects in the sustainability assessment of wood in vehicles
Authors: Mair-Bauernfeind Claudia , Zimek Martina , Lettner Miriam , Hesser Franziska , Baumgartner Rupert J. , Stern Tobias 
Published: September 2020

Abstract
Purpose
The choice of materials used for a vehicle can contribute to reduce negative environmental and social impacts. Bio-based materials are considered a promising solution; however, the sustainability effects still need to be assessed. Depending on the material assessed, it is questionable which environmental and social impact categories or subcategories should be included since recommendations in guidelines are vague and case studies in this regard are limited. Therefore, this study aims to shed light on the choice of impact categories, methods, and indicators for E-LCA and S-LCA when assessing wood as substitute for conventional materials in automotive applications.

Method
The research is based on a literature review covering 115 case studies of S-LCAs and E-LCAs focusing either on wood-based products or on components in automotive applications. The selected case studies were analyzed according to the following criteria: considered stakeholder groups and chosen subcategories (S-LCA sample), sector or product system (S-LCA sample), year of publication and geographical scope (S-LCA and E-LCA sample), chosen LCIA method(s) and impact categories, objective(s) of the studies, analyzed materials and used software support (E-LCA samples).

Results and discussion
For S-LCA some relevant social topics for bio-based product systems, like food security or land- and worker-related concerns, could be identified. The E-LCA literature suggests that the objective and material type determine calculation approaches and impact category choices. Some material-related environmental issues like biodiversity loss in the case of bio-based product systems or ecotoxicity for steel and toxicity in the case of aluminum could be identified. For S-LCA the geographical and sectorial context and the affected stakeholders are the determining factors for methodical choices, however, the results show almost no difference in subcategory choice and geographical context. Influencing factors for methodical choices in E-LCA might be the objective of the study, data availability, the up-to-dateness of the LCIA approach, the geographical scope of the study, the materials analyzed, and the availability of software support.

Conclusion
Some relevant environmental and social impact categories as well as influencing factors on methodical choices could be identified from existing literature. However, a clear picture on these issues could not be drawn. Further research is needed on the motivation of researches on certain methodical choices as well as on environmental issues connected with materials or geographical-related social topics.