bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate Change Projections for the Australian Monsoon From CMIP6 Models
Authors: Narsey S. Y. , Brown J. R. , Colman R. A. , Delage F. , Power S. B. , Moise A. F. , Zhang H. 
Published: March 2020

AbstractClimate change projections for the Australian monsoon have been highly uncertain in previous generations of coupled climate models. The new Coupled Model Intercomparison Project Phase 6 (CMIP6) ensemble provides an opportunity to address the uncertainty in future projections for northern Australia. We find that the range in Australian monsoon projections from the available CMIP6 ensemble is substantially reduced compared to CMIP5, although models continue to disagree on the magnitude and direction of change. While previous CMIP5 studies identified warming in the western equatorial Pacific as important for Australian monsoon projections, here we show that the western Pacific is not strongly connected to northern Australian precipitation changes in the CMIP6 models. By comparing groups of models based on their future projections, we note that the model‐to‐model differences in Australian monsoon projections are congruent with the zonally averaged precipitation response in the Southern Hemisphere tropics within each model.
Response of Ionospheric Equatorial Ionization Crests to Lunar Phase
Authors: Wu Tsung‐Yu , Liu Jann‐Yenq , Lin Chi‐Yen , Chang Loren C. 
Published: March 2020

AbstractThe strength, appearance time, and latitudinal location of the equatorial ionization anomaly (EIA) crest response to the lunar phase are examined using the total electron content of global ionosphere maps during the 18‐year period of 2000–2017. The total electron content of the EIA crest reveals semidiurnal tides with 12.42‐hr period, while the appearance time and latitude of the EIA crests present prominent semimonthly lunar tides of 14.77‐day period. The EIA crests on new/full moon (first/third quarter) lead (lag) those of the overall 18‐year average by about 20–40 min, while the EIA crests move the furthest poleward and equatorward 2–5 days after new/full moon and first/third quarter, respectively. Amplitudes of the semimonthly lunar tide in the EIA crest appearance times and latitudes yield the greatest value around perihelion and the smallest value around aphelion, which shows that the solar declination and seasonal effects are important.
Excessive Momentum and False Alarms in Late‐Spring ENSO Forecasts
Authors: Tippett Michael K. , L'Heureux Michelle L. , Becker Emily J. , Kumar Arun 
Published: March 2020

AbstractThe unanticipated stalled El Niño‐Southern Oscillation (ENSO) evolution of 2014 raises questions about the reliability of the coupled models that were used for forecast guidance. Here we have analyzed the skill and reliability of forecasts of the Niño 3.4 tendency (3‐month change) in the North American multimodel ensemble (1982–2018). We found that forecasts initialized April–June (AMJ) have “excessive momentum” in the sense that the forecast Niño 3.4 tendency is more likely to be a continuation of the prior observed conditions than it should be. Models tend to predict warming when initialized after observed warming conditions and cooling when initialized after observed cooling conditions. Excessive momentum appears in AMJ forecast busts and false alarms including the 2014 one. In some models, excessive momentum appears to be related to model formulation rather than initialization. A concerning trend is that four of the nine years with AMJ forecast busts occurred in the last decade.
Tectonic Uplift Destabilizes Subsea Gas Hydrate: A Model Example From Hikurangi Margin, New Zealand
Authors: Burton Zachary F. M. , Kroeger Karsten F. , Hosford Scheirer Allegra , Seol Yongkoo , Burgreen‐Chan Blair , Graham Stephan A. 
Published: March 2020

AbstractRising ocean temperatures and falling sea level are commonly cited as mechanisms of marine gas hydrate destabilization. More recently, uplift—both isostatic and tectonic—has been invoked. However, the effect of tectonic shortening and uplift on gas hydrate stability zone extent has not been validated via integrated computational modeling. Here, modeling along the Hikurangi margin of New Zealand illustrates the mechanism of tectonic uplift as a driver of gas hydrate destabilization. We simulate how tectonic uplift and shortening affect the presence and decrease the extent of a gas hydrate stability zone. We suggest that resultant gas hydrate destabilization in the marine realm may impact the global carbon cycle and oceanic chemistry over geologic time.
Sensitivity of Tropospheric Ozone Over the Southeast USA to Dry Deposition
Authors: Baublitz Colleen B. , Fiore Arlene M. , Clifton Olivia E. , Mao Jingqiu , Li Jingyi , Correa Gus , Westervelt Daniel M. , Horowitz Larry W. , Paulot Fabien , Williams A. Park 
Published: March 2020

AbstractDry deposition (DD) is a major loss process for tropospheric ozone and some reactive nitrogen and carbon precursors. We investigate the response of summertime ozone and its production chemistry over the Southeast United States (USA) to variability in this sink. Turning off DD of oxidized nitrogen, ozone, or all species over the United States in the Geophysical Fluid Dynamics Laboratory AM3 model increases regional mean surface ozone by 5, 18, or 25 ppb, respectively. Additional sensitivity simulations demonstrate that, assuming linearity, surface ozone has a similar sensitivity to ozone DD as to NOx emissions. Trends in ozone production efficiency derived from observed relationships between ozone and precursor oxidation products may not solely reflect precursor emission changes if ozone DD varies (e.g., with meteorology). We conclude that DD variability merits consideration when interpreting observed ozone trends. Quantifying the impact of changes in sinks versus sources will require long‐term DD measurements across the region of interest.
Homogenization of Dissolution and Enhanced Precipitation Induced by Bubbles in Multiphase Flow Systems
Authors: Jiménez‐Martínez Joaquín , Hyman Jeffrey D. , Chen Yu , Carey J. William , Porter Mark L. , Kang Qinjun , Guthrie George , Viswanathan Hari S. 
Published: March 2020

AbstractMultiphase flow is ubiquitous in subsurface energy applications and natural processes, such as oil recovery, CO2 sequestration, and water flow in soils. Despite its importance, we still lack a thorough understanding of the coupling of multiphase flow and reaction of transported fluids with the confining media, including rock dissolution and mineral precipitation. Through the use of geomaterial microfluidic flow experiments and high‐performance computer simulations, we identify key pore‐scale mechanisms that control this coupling. We compare the reactivity of fractured limestone with CO2‐saturated brine (single phase) and a mixture of supercritical (sc) CO2 and CO2‐saturated brine (multiphase). We find that the presence of scCO2 bubbles significantly changes both the flow dynamics and the resulting reaction patterns from a single‐phase system, spatially homogenizing the rock dissolution. In addition, bubbles redirect oversaturated fluid into low‐velocity regions, thereby enhancing carbonate precipitation occurs.
Groundwater Release on Early Mars: Utilizing Models and Proposed Evidence for Groundwater Release to Estimate the Required Climate and Subsurface Water Budget
Authors: Palumbo Ashley M. , Head James W. 
Published: March 2020

AbstractIt has been proposed that groundwater was released onto the early martian surface in several locations, including Meridiani Planum, NE Hellas, Terra Sirenum, the northern lowlands, and Gale crater. We assume that groundwater was released in a manner similar to a groundwater‐fed lake on Earth and then use a combination of a global climate model and mathematical relationships to place lower limit estimates on the early climate and subsurface water inventory that are required for groundwater release to occur at all of these locations. We find that the minimum required conditions are global mean annual temperature >284 K and a subsurface water inventory >496 m global equivalent layer. Additionally, thermal models predict that if such warm conditions occurred from punctuated heating in an otherwise “cold and icy” climate, the warm conditions must have persisted for thousands of years in order to remove the cryosphere and permit groundwater release.
Fragments Delivered by Secondary Craters at the Chang'E‐4 Landing Site
Authors: Ding Chunyu , Xiao Zhiyong , Wu Bo , Li Yuan , Prieur Nils C. , Cai Yuzhen , Su Yan , Cui Jun 
Published: March 2020

AbstractThe Chang'E‐4 landing site is depleted with boulders seen from both orbit and surface. However, the Yutu‐2 rover came across thousands of concreted fragments in and around an abnormally fresh crater that has more elevated northwestern rims. The origin of the fragments is crucial to resolve the provenances of surface materials detected by the rover. The lunar penetrating radar performed two in‐and‐out scans for the blocky ejecta, revealing that the subsurface materials have indistinguishable radar permittivity with the surrounding regolith. Forward modeling of electromagnetic wave propagation shows that the fragments were not an original component in the subsurface. This crater is among the several fresh craters photoed by the rover, and they are located in an eastern extension ray of the Zhinyu crater. The small craters are likely secondaries of Zhinyu, and the fragments contain a mixture of shattered projectiles and most likely compacted regolith clumps formed during the secondary impacts.
Relative Roles of Low‐Level Wind Speed and Moisture in the Diurnal Cycle of Rainfall Over a Tropical Island Under Monsoonal Flows
Authors: Zhu Lei , Chen Xingchao , Bai Lanqiang 
Published: March 2020

AbstractUsing satellite observations and reanalysis data, this study investigates the relative roles of low‐level wind speed and moisture content in the rainfall diurnal cycle over a tropical island influenced by monsoonal winds. Results show that the spatiotemporal characteristics of rainfall over the island are evidently influenced by the two factors. Specifically, the spatial distribution of rainfall is primarily determined by the low‐level wind speeds, while the rainfall diurnal cycle is influenced by both factors. Weaker low‐level wind speed leads to stronger and wider inland convergence and afternoon precipitation, which are mainly produced by the inland penetrating sea breeze fronts. Nighttime rainfall over the island is closely related to the inertial oscillation. Stronger nocturnal rainfall can be found with higher low‐level moisture content and stronger monsoonal winds. The multiscale interactions between the large‐scale circulation, land–sea breezes, and inertial oscillation play essential roles in modulating the rainfall over this tropical island.
Future Changes of Summer Monsoon Characteristics and Evaporative Demand Over Asia in CMIP6 Simulations
Authors: Ha Kyung‐Ja , Moon Suyeon , Timmermann Axel , Kim Daeha 
Published: March 2020

AbstractFuture greenhouse warming is expected to influence the characteristics of global monsoon systems. However, large regional uncertainties still remain. Here we use 16 Coupled Model Intercomparison Project Phase 6 (CMIP6) models to determine how the length of the summer rainy season and precipitation extremes over the Asian summer monsoon domain will change in response to greenhouse warming. Over East Asia the models simulate on average on the earlier onset and later retreat; whereas over India, the retreat will occur later. The model simulations also show an intensification of extreme rainfall events, as well as an increase of seasonal drought conditions. These results demonstrate the high volatility of the Asian summer monsoon systems and further highlight the need for improved water management strategies in this densely populated part of the world.
Climate Change and Social Unrest: A 6,000‐Year Chronicle From the Eastern Mediterranean
Authors: Kaniewski David , Marriner Nick , Cheddadi Rachid , Fischer Peter M. , Otto Thierry , Luce Frédéric , Van Campo Elise 
Published: March 2020

AbstractThe history of the Eastern Mediterranean is punctuated by major crises that have influenced many of the region's established socioeconomic models. Recent studies have underscored the role of drought and temperature oscillations in driving changes but attempts to quantify their magnitude remain equivocal, hindering long‐term assessments of the potential interplay between climate and society. Here, we fill this knowledge gap using a 6,000‐year pollen‐based reconstruction of temperature and precipitation from Hala Sultan Tekke, Cyprus. We find that major social changes and plague outbreaks often occurred in tandem with cooler climate conditions, with anomalies ranging from −3 ± 0.4 °C to −1 ± 0.5 °C, coupled with changing precipitation patterns. We suggest that major climate changes may weaken societies by affecting primary livelihood systems. This long‐term view highlights recurrent cold periods in the Eastern Mediterranean's climate history and advocates that, despite frequent adversity and pandemics, Near Eastern populations adapted and were ultimately resilient to major climate changes.
New insights into the functions of Cox-2 in skin and esophageal malignancies
Authors: Moon Hyeongsun , White Andrew C. , Borowsky Alexander D. 
Published: April 2020

AbstractUnderstanding the cellular and molecular mechanisms of tumor initiation and progression for each cancer type is central to making improvements in both prevention and therapy. Identifying the cancer cells of origin and the necessary and sufficient mechanisms of transformation and progression provide opportunities for improved specific clinical interventions. In the last few decades, advanced genetic manipulation techniques have facilitated rapid progress in defining the etiologies of cancers and their cells of origin. Recent studies driven by various groups have provided experimental evidence indicating the cellular origins for each type of skin and esophageal cancer and have identified underlying mechanisms that stem/progenitor cells use to initiate tumor development. Specifically, cyclooxygenase-2 (Cox-2) is associated with tumor initiation and progression in many cancer types. Recent studies provide data demonstrating the roles of Cox-2 in skin and esophageal malignancies, especially in squamous cell carcinomas (SCCs) occurring in both sites. Here, we review experimental evidence aiming to define the origins of skin and esophageal cancers and discuss how Cox-2 contributes to tumorigenesis and differentiation.
Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth
Authors: Uka Rexhep , Britschgi Christian , Krättli Anja , Matter Claudia , Mihic Daniela , Okoniewski Michal J. , Gualandi Marco , Stupp Roger , Cinelli Paolo , Dummer Reinhard , Levesque Mitchell P. , Shakhova Olga 
Published: April 2020

AbstractDespite advances in the systemic treatment of patients with metastatic melanoma using immune checkpoint and tyrosine kinase inhibitors (TKI), the majority of stage IV melanoma patients eventually succumb to the disease. We have previously identified the transcription factor Sox10 as a crucial player in melanoma, yet the underlying molecular mechanisms mediating Sox10-dependent tumorigenesis remain largely uncharacterized. Here, we show that MEK and RAF inhibitors do not suppress levels of SOX10 protein in patient-derived cells in vitro, as well as in melanoma patients in vivo. In a search for pharmacological inhibitors of SOX10, we performed a mass spectrometry-based screen in human melanoma cells. Subsequent analysis revealed that SOX10 directly interacts with β-catenin, which is a key mediator of canonical Wnt/β-catenin signaling. We demonstrate that inhibitors of glycogen synthase kinase 3 alpha/beta (GSK3α/β) efficiently abrogate SOX10 protein in human melanoma cells in vitro and in melanoma mouse models in vivo. The mechanism of action of GSK3-mediated SOX10 suppression is transcription-independent and relies on the presence of a proteasome degradable form of β-catenin. Taken together, we provide evidence that activation of canonical Wnt signaling has a profound effect on melanoma growth and is able to counteract Sox10-dependent melanoma maintenance both in vitro and in vivo.
Willingness to donate genomic and other medical data: results from Germany
Authors: Voigt Torsten H. , Holtz Verena , Niemiec Emilia , Howard Heidi C. , Middleton Anna , Prainsack Barbara 
Published: April 2020

AbstractThis paper reports findings from Germany-based participants in the “Your DNA, Your Say” study, a collaborative effort among researchers in more than 20 countries across the world to explore public attitudes, values and opinions towards willingness to donate genomic and other personal data for use by others. Based on a representative sample of German residents (n = 1506) who completed the German-language version of the survey, we found that views of genetic exceptionalism were less prevalent in the German-language arm of the study than in the English-language arm (43% versus 52%). Also, people’s willingness to make their data available for research was lower in the German than in the English-language samples of the study (56% versus 67%). In the German sample, those who were more familiar with genetics, and those holding views of genetic exceptionalism were more likely to be willing to donate data than others. We explain these findings with reference to the important role that the “right of informational self-determination” plays in German public discourse. Rather than being a particularly strict interpretation of privacy in the sense of a right to be left alone, the German understanding of informational self-determination bestows on each citizen the responsibility to carefully consider how their personal data should be used to protect important rights and to serve the public good.
Whole exome sequencing in ADHD trios from single and multi-incident families implicates new candidate genes and highlights polygenic transmission
Authors: Al-Mubarak Bashayer R. , Omar Aisha , Baz Batoul , Al-Abdulaziz Basma , Magrashi Amna I. , Al-Yemni Eman , Jabaan Amjad , Monies Dorota , Abouelhoda Mohamed , Abebe Dejene , Ghaziuddin Mohammad , Al-Tassan Nada A. 
Published: April 2020

AbstractSeveral types of genetic alterations occurring at numerous loci have been described in attention deficit hyperactivity disorder (ADHD). However, the role of rare single nucleotide variants (SNVs) remains under investigated. Here, we sought to identify rare SNVs with predicted deleterious effect that may contribute to ADHD risk. We chose to study ADHD families (including multi-incident) from a population with a high rate of consanguinity in which genetic risk factors tend to accumulate and therefore increasing the chance of detecting risk alleles. We employed whole exome sequencing (WES) to interrogate the entire coding region of 16 trios with ADHD. We also performed enrichment analysis on our final list of genes to identify the overrepresented biological processes. A total of 32 rare variants with predicted damaging effect were identified in 31 genes. At least two variants were detected per proband, most of which were not exclusive to the affected individuals. In addition, the majority of our candidate genes have not been previously described in ADHD including five genes (NEK4,NLE1,PSRC1,PTP4A3,andTMEM183A) that were not previously described in any human condition. Moreover, enrichment analysis highlighted brain-relevant biological themes such as “Glutamatergic synapse”, “Cytoskeleton organization”, and “Ca2+pathway”. In conclusion, our findings are in keeping with prior studies demonstrating the highly challenging genetic architecture of ADHD involving low penetrance, variable expressivity and locus heterogeneity.
Combined Mini-Parasep SF and Nanogold Immunoassay Show Potential in Stool Antigen Immunodetection for Giardiasis Diagnosis
Authors: Mohram Ahlam F. , Elawamy Waleed E. , Nageeb Marwa M. , Ali Hemat S. , Kishik Shereen M. 
Published: March 2020

AbstractCovalent loading or directional binding of biomolecules on gold nanoparticles (AuNPs) could lead to better results than simple direct adsorption for an enhanced ELISA application. The use of Mini-Parasep solvent-free (SF) without ether or ethyl acetate for the clean and efficient concentration of protozoa cysts, it is a single-use device for in vitro diagnostic use only. In this work, we used Mini-Parasep SF for the detection of giardia cysts in comparison to direct smear and Merthiolate-Iodine Formaldehyde Concentration (MIFC) technique in addition to its use in antigen detection by AuNPs biomolecule loading using rabbit polyclonal antibodies (pAb) against purified Giardia antigen (PGA). As a result, Mini-Parasep SF was the most effective method for Giardia cyst detection and regarding optimization of Mini-Parasep antigen detection, our data showed increased sensitivity and specificity of nano-sandwich ELISA to 92% and 94% respectively and increased positive predictive value (PPV) and negative predictive value (NPV) to 88.64% and 95.91% respectively. In conclusion, this research provides that Mini-Parasep SF concentrator enhanced Giardia cyst detection and improved antigen preparation for AuNPs sandwich ELISA in giardiasis diagnosis. The advantages of this method are the short assay time and the raised accuracy of antigen detection providing concentrated samples without the risk of solvent use and being a disposable Mini-Parasep it helps in giardia antigen purification as well as raising the sensitivity and specificity of ELISA through binding AuNPs.
Albendazole negatively regulates keratinocyte proliferation
Authors: Di Fusco Davide , Stolfi Carmine , Di Grazia Antonio , Dinallo Vincenzo , Laudisi Federica , Marafini Irene , Colantoni Alfredo , Monteleone Ivan , Monteleone Giovanni 
Published: April 2020

Abstract
Background: Increased keratinocyte proliferation occurs in the skin of psoriatic patients and is supposed to play a role in the pathogenesis of this disorder. Compounds interfering with keratinocyte proliferation could be useful in the management of psoriatic patients.
Aim: To investigate whether albendazole, an anti-helmintic drug that regulates epithelial cell function in various systems, inhibits keratinocyte proliferation in models of psoriasis.
Methods: Aldara-treated mice received daily topical application of albendazole. Keratinocyte proliferation and keratin (K) 6 and K16 expression were evaluated by immunohistochemistry and Western blotting and inflammatory cells/mediators were analysed by immunohistochemistry and real-time PCR. In human keratinocytes (HEKa and HaCaT) treated with albendazole, cell cycle and proliferation, keratins and cell cycle-associated factors were evaluated by flow cytometry, colorimetric assay and Western blotting respectively.
Results: Aldara-treated mice given albendazole exhibited reduced epidermal thickness, decreased number of proliferating keratinocytes and K6/K16 expression. Reduction of CD3- and Ly6G-positive cells in the skin of albendazole-treated mice associated with inhibition of IL-6, TNF-α, IL-1β, IL-17A, IL-36, CCL17, CXCL1, CXCL2 and CXCL5 expression. Treatment of keratinocytes with albendazole reduced K6/K16 expression and reversibly inhibited cell growth by promoting accumulation of cells in S-phase. This phenomenon was accompanied by down-regulation of CDC25A, a phosphatase regulating progression of cell cycle through S-phase, and PKR-dependent hyper-phosphorylation of eIF2α, an inhibitor of CDC25 translation. In Aldara-treated mice, albendazole activated PKR, enhanced eIF2α phosphorylation and reduced CDC25A expression.
Conclusions: Data show that albendazole inhibits keratinocyte proliferation and exerts therapeutic effect in a murine model of psoriasis.