bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
Authors: Nayak Chintamani , Pattanaik Nivedita , Chattopadhyay Abhijit , Misra Pankhuri , Bhar Koushik , Michael James , Koley Munmun , Saha Subhranil 
Published: October 2020

Abstract

Objectives
The quality of management of hyperuricemia has remained sub-optimal owing to unavoidable toxicities, limitations, and dearth of novel advances. Homeopathy has remained under-researched in hyperuricemia. We investigated the clinical effectiveness of three treatment regimens – individualized homeopathy (IH), Urtica urens mother tincture (UUMT), and both (IH + UUMT) along with lifestyle modifications in a sample of 90 patients with hyperuricemia.

Methods
An open, randomized (1:1:1), 3 parallel arms (IH, UUMT, and IH + UUMT), pragmatic trial was conducted at National Institute of Homoeopathy, Kolkata. Outcome measures were serum uric acid (primary), Gout Assessment Questionnaire version 2 (GAQ2, secondary), and Measure Yourself Medical Outcome Profile version 2 (MYMOP2, secondary); all measured at baseline, and after 3 and 6 months. Intention- to-treat sample was analyzed to detect group differences by unpaired t tests.

Results
Attrition rate was 8.9% (IH: 3, UUMT: 3, IH + UUMT: 2). Groups were comparable at baseline. Reductions in serum uric acid over 3 months were comparatively higher (p=0.057) in the UUMT group than others, however, the differences were narrowed over 6 months (p=0.119). Per protocol analysis of serum uric acid level revealed similar trend of significantly higher reduction in the UUMT group than the other two (3 months: p=0.001; 6 months: p=0.007). No significant differences existed in reductions of GAQ2 scores among the three groups. Few significant differences were detected in MYMOP scores over 3 months favoring IH against others (symptom 2, p=0.001 and wellbeing score, p=0.002), and also over 6 months favoring IH + UUMT against others (symptom 1, p<0.001).

Conclusion
Although all three therapies showed similar improvements, the IH + UUMT group had more positive direction of effects than IH or UUMT alone; however, no definite conclusion could be arrived at. Further trials are warranted with larger sample size. Trial registration: CTRI/2018/05/014026.
Econometrics Pedagogy and Cloud Computing: Training the Next Generation of Economists and Data Scientists
Authors: Handel Danielle V. , Ho Anson T. Y. , Huynh Kim P. , Jacho-Chávez David T. , Rea Carson H. 
Published: October 2020

Abstract
This paper describes how cloud computing tools widely used in the instruction of data scientists can be introduced and taught to economics students as part of their curriculum. The demonstration centers around a workflow where the instructor creates a virtual server and the students only need Internet access and a web browser to complete in-class tutorials, assignments, or exams. Given how prevalent cloud computing platforms are becoming for data science, introducing these techniques into students’ econometrics training would prepare them to be more competitive when job hunting, while making instructors and administrators re-think what a computer laboratory means on campus.
Developing a Case-based Emergency Response System with Adaptive Case Management
Authors: Shahrah Abobakr Y. , Al-Mashari Majed A. 
Published: October 2020

Abstract
The emergency responses required during large-scale crises or disasters are extremely knowledge-intensive processes and are usually characterized by a high degree of unpredictability and unrepeatability. An emergency response is mission- and time-critical, unstructured, very dynamic, and it is very difficult to predefine or even to anticipate all possible response scenarios. Therefore, designing and implementing a software system to support such a response system is highly complicated and challenging. This research aims to investigate and discuss how Adaptive Case Management (ACM) can be leveraged in the design and implementation of a case-based emergency response system. In particular, this research considers the best practices of the National Incident Management System (NIMS), which is an essential part of the National Response Framework (NRF) developed in the United States. As a proof-of-concept, a prototype demonstration has been carried out on a leading commercial ACM platform. In addition, a walkthrough scenario is discussed to elaborate how ACM can support emergency response activities in real settings using the Incident Command System (ICS) organizational structure. The key benefit of this research is to guide the development and implementation of cased-based emergency response systems with a flexible and agile approach.
Performance analysis of carrier depletion silicon PIN phase shifter
Authors: Ramesh Gabriel Jesuwanth Sugesh , Arunagiri Sivasubramanian 
Published: October 2020

Abstract
In this paper, we report the performance of a carrier depletion Silicon PIN phase shifter with over layer of 130 nm. It is observed that an optimum intrinsic gap of 250 nm for a device length of 5 mm at 2 V, resulted in Extinction Ratio (ER) of 23.41 dB and Bit Error Rate (BER) of 1.00 × 10−7 is obtained for 50 Gbps. The phase shifter is also designed for length 2 mm with an intrinsic gap of 100 nm at an operating voltage <4 V. The study also reveals that the proposed design for Mach-Zehnder modulator operating at a data rate of 100 Gbps for the concentration of P = 7 × 1017 cm−3 and N = 5 × 1017 cm−3 gives better BER and phase performance. The proposed design was also analysed in an intra-data centre communication setup of fibre length 15 km.
The influence of race on cervical length in pregnant women in Brazil
Authors: Minis Evelyn , Fernandes Moron Antonio , Hatanaka Alan , Sarmento Stephanno G. P. , Santucci Marcelo , Carvalho Francisco H. C. , Hamamoto Tatiana K. , Mattar Rosiana , Linhares Iara M. , Sabino Ester C. , Forney Larry J. , Witkin Steven S. 
Published: October 2020

Abstract

Objectives
Short cervical length is a predictor of preterm birth. We evaluated if there were racial differences in variables associated with cervical length in pregnant Brazilian women.

Methods
Cervical length was determined by vaginal ultrasound in 414 women at 21 weeks gestation. All women were seen at the same clinic and analyzed by the same investigators. Women found to have a short cervix (≤25 mm) received vaginal progesterone throughout gestation. Composition of the vaginal microbiome was determined by analysis of the V1–V3 region of the gene coding for bacterial 16S ribosomal RNA. Demographic, clinical and outcome variables were determined by chart review. Subjects were 53.4% White, 37.2% mixed race and 9.4% Black.

Results
Pregnancy, medical history and education level were similar in all groups. Mean cervical length was shorter in Black women (28.4 mm) than in White (32.4 mm) or mixed race (32.8 mm) women (p≤0.016) as was the percentage of women with a short cervix (23.1, 12.2, 7.8% in Black, White, mixed race respectively) (p≤0.026). Mean cervical length increased with maternal age in White (p=0.001) and mixed race (p=0.045) women but not Black women. There were no differences in bacterial dominance in the vaginal microbiota between groups. Most women with a short cervix delivered at term.

Conclusions
We conclude that Black women in Brazil have a shorter cervical length than White or mixed race women independent of maternal age, pregnancy and demographic history or composition of the vaginal microbiome.
Hyperechoic amniotic membranes in patients with preterm premature rupture of membranes (p-PROM) and pregnancy outcome
Authors: Volpe Nicola , di Pasquo Elvira , Ferretti Alice , Dall’Asta Andrea , Fieni Stefania , Frusca Tiziana , Ghi Tullio 
Published: October 2020

Abstract

Objectives
The early identification of women with preterm premature rupture of membranes (p-PROM) who are at higher risk of imminent delivery remains challenging. The aim of our study was to evaluate if an increased echogenicity of the amniotic membranes may represent a sonographic marker of impending delivery in women with p-PROM.

Methods
This was a prospective study including women with singleton pregnancies and diagnosis of p-PROM between 22 and 37 gestational weeks. A sonographic examination was performed within 24 h from the hospital admission and the appearance of the amniotic membranes close to the internal os was specifically evaluated. The membranes were defined as hyperechoic when their echogenicity was similar to that of the fetal bones or normoechoic in the other cases. The primary aim of the study was to compare the admission to spontaneous onset of labor interval and the pregnancy outcome between the cases of p-PROM with and without hyperechoic membranes.

Results
Overall, 45 women fulfilled the inclusion criteria with similar characteristics at admission. In women with hyperechoic membranes, the admission to spontaneous onset of labor interval was significantly shorter (11.5 [5.3–25.0] vs. 3.0 [1.5–9.0] p=0.04) compared to women with normo-echoic membranes. At binomial logistic regression after adjustment for GA at hospital admission, the presence of hyperechoic membranes was found as the only independent predictor of spontaneous onset of labor ≤72 h (aOR: 6.1; 95% CI: 1.0–36.9)

Conclusions
The presence of hyperechoic membranes is associated with a 6-fold higher incidence of spontaneous onset of labor within 72 h independently from the gestational age at p-PROM.
Reference intervals and reliability of cavum septi pellucidi volume measurements by three-dimensional ultrasound between 19 and 24 weeks’ gestation
Authors: Cinar Aslim , Sezik Mekin , Yalcin Serenat Eris , Yavuz And 
Published: October 2020

Abstract

Objectives
A small or a large cavum septi pellucidi (CSP) during routine second trimester sonography may suggest abnormal cerebral development. Therefore, determination of CSP volume with three-dimensional (3D) ultrasound can be valuable. For this purpose, we sought to evaluate the reference ranges and measurement reliability of CSP volume by Virtual Organ Computer-aided AnaLysis (VOCAL).

Methods
VOCAL software was used to calculate the CSP volume from transabdominal multiplanar datasets of 99 structurally normal fetal ultrasound examinations between 19 and 24 weeks of gestation. Linear regression was utilized to determine reference intervals for CSP volumes as a function of gestational week (GW). Agreement among three evaluators with different proficiency levels (obstetrics and gynecology resident, perinatology fellow, and perinatologist) was assessed, using intraclass correlation coefficients (ICC) and 95% confidence intervals (CI).

Results
CSP volume and gestational age was positively correlated (r2=0.383, p=0.0001), represented by the following equation: 0.058–(1.016 x GW). Interobserver agreement between perinatologist and fellow was relatively high (ICC, 0.78; 95% CI, 0.70–0.85), whereas limited ultrasound experience (resident) was associated with fair agreement with non-novice observers (ICC for resident and perinatologist, 0.50; 95% CI, 0.29–0.65 and ICC for resident and fellow, 0.57; 95% CI, 0.38–0.71).

Conclusions
Reference ranges of CSP volumes using VOCAL from 19 0/6 through 24 6/7 weeks of gestation were established. A first-degree model to estimate CSP volume as a function of gestational age was also constructed. CSP volumetry seems reliable when evaluated by an examiner with particular 3D sonography experience.
First-trimester presentation of ultrasound findings in trisomy 13 and validation of multiparameter ultrasound-based risk calculation models to detect trisomy 13 in the late first trimester
Authors: Rajs Bartosz , Nocuń Agnieszka , Matyszkiewicz Anna , Pasternok Marcin , Kołodziejski Michał , Wiercińska Ewa , Wiecheć Marcin 
Published: October 2020

Abstract

Objectives
To identify the most common ultrasound patterns of markers and anomalies associated with Patau syndrome (PS), to explore the efficacy of multiparameter sonographic protocols in detecting trisomy 13 (T13) and to analyze the influence of maternal age (MA) on screening performance.

Methods
The project was a prospective study based on singleton pregnancies referred for a first-trimester screening examination. The scan protocol included nuchal translucency (NT), fetal heart rate (FHR), secondary ultrasound markers [nasal bone (NB), tricuspid regurgitation (TR), ductus venosus reversed a-wave (revDV)] and major anomaly findings.

Results
The study population comprised 6133 pregnancies: 6077 cases of euploidy and 56 cases of T13. Statistically significant differences were found in MA, FHR, NT, absence of NB, presence of revDV, TR and single umbilical artery. Fourteen cases of T13 (25%) demonstrated no markers of aneuploidy. The best general detection rate (DR) (DR of 78.6% with an false positive rate (FPR) of 1.2%) was obtained for a cutoff of 1/300 utilizing the “NT+T13” algorithm. The logistic regression model revealed that the central nervous system (CNS) anomalies had the greatest odds ratio (of 205.4) for T13.

Conclusions
The effectiveness of the multiparameter sonographic protocol used for T13 screening showed promising results in patients older than 36 years and suboptimal results in patients between 26 and 36 years old. When screening for T13 left heart defects, CNS anomalies, abdominal anomalies, FHR above the 95th percentile, increased NT, revDV and lack of NB should receive specific attention.
Optimization of a molecular diagnostic strategy to verify SARS-CoV-2 infections by RT-qPCR
Authors: Noßmann Marcel 
Published: October 2020

Abstract

Objectives
Fast and precise detection of SARS-CoV-2 RNA in infected patients is essential for treatment decisions.

Methods
A diagnostic strategy by analyzing nasopharyngeal swabs to detect SARS-CoV-2 RNA in individuals was established. The negative impacts of the individual buffer components on RT-qPCR analysis was reviewed and overcome by RNA purification. To investigate the functionality of the improved protocol we compared the novel diagnostic strategy to a Bead-based RNA extraction method using previously positive tested samples.

Results
A method to extract purify RNA molecules from SARS-CoV-2 was established. We examined the significance of nucleic acid purification and the need for an RNase inhibitor. Evaluation of 3,664 samples from March 23rd until May 18th in 2020 showed the incidence of COVID-19 infections in Thuringia, Germany. Additionally, benefits and limits of three RT-qPCR kits were assessed.

Conclusions
Our study suggests that virus capsid lysis combined with nucleic acid purification enables a viable alternative for the molecular diagnostics of SARS-CoV-2 infections. Due to the current delivery delays from different companies, this method offers the possibility to continue diagnosis and to handle the large number of samples.
Aspects of the Never-Ending Translation Wars in South Korea
Authors: Schirmer Andreas 
Published: October 2020

Abstract
Translation has always played a major role in Korea’s often painful process of modernization. But even in this context, the frequent “translation wars” are a striking phenomenon—especially when the zealous battles about mistranslations are fought not only within the limited confines of professional or aficionado circles, but also (as periodically occurs) captivate the general public. The fact that public discourse about the quality and reliability of translations is much more common in South Korea than anywhere in the West is very telling in cultural anthropological terms. This significance has, however, never been considered a matter deserving of academic attention in and of itself. Conspicuously, the public denunciation of translation mistakes, as practiced in Korea, often targets not only the immediate culprits but claims to expose a fundamental (culturally conditioned) mentality among the general Korean population. The implication is that Korean audiences lack self-assurance and tend to accept dubious passages meekly because they are conditioned to suspect themselves of being simply too stupid to understand. Korea’s ongoing translation wars are epitomized by encyclopedic books that present vast collections of detected mistakes and usually receive a great deal of media coverage. One regularly recurring motif of the multifaceted debates on mistranslations is the supposed disgrace and disadvantage sustained by Koreans when they are left with imperfect renderings of insights easily gleaned by those elsewhere in the world, who read, if not the originals, at least perfectly faithful translations.
Manner salience and translation: A case study based on a multilingual corpus of graphic novels
Authors: Molés-Cases Teresa 
Published: October 2020

AbstractThis paper examines the salience of Manner-of-motion and its translation in a multilingual corpus of graphic novels, with the dual aim of further investigating the role of visual language in Slobin’s Thinking-for-translating hypothesis and identifying the relevant translation techniques. Many studies that draw on the hypothesis have shown, for instance, that, in the translation process from a satellite-framed language (e. g. German, English) into a verb-framed language (e. g. Spanish, French), Manner-of-motion is usually omitted, whereas in the translation process between languages belonging to the same typological group, it is generally transferred, although some intratypological variation has also been identified in the literature. The corpus studied allows both inter- and intratypological analyses: it is composed of two graphic novels by the Austrian cartoonist Ulli Lust and their corresponding translations into Spanish, French and English. The resulting data were compared with previous research in the field. The paper concludes that, although visual language minimizes the consequences of Thinking-for-translating, the conventions and restrictions of graphic novels deserve greater attention within this framework.
Distribution of the dwarf dog-faced bat Molossops temminckii (Chiroptera: Molossidae) in Colombia and comments on its morphometry
Authors: Chacón-Pacheco Julio J. , Avendaño Maldonado Luis José , Agamez-López Carlos , Mejía-Fontecha Ingrith Yuliany , Velásquez-Guarín Daniela , Ossa López Paula A. , Rivera Páez Fredy A. , Morales-Martínez Darwin M. , Ramírez-Chaves Héctor E. 
Published: October 2020

Abstract
The genus Molossops includes two species that are restricted to South America: Molossops neglectus and Molossops temminckii. The smaller dog-faced dwarf Molossops temminckii is distributed from Colombia to Argentina and has a wide morphological variation and vocal plasticity. In Colombia, this species remains poorly known. To fill distributional gaps, we present novel records from Arauca, Atlántico, Bolívar, Córdoba, and Huila departments. We also present an analysis of the morphometric variation in South America using Principal Component Analyses. These show an external and cranial difference of specimens of Colombia in respect of other and South America populations. In Colombian landscapes dominated by the floodplain savanna of the Orinoco region, Molossops temminckii is smaller than in the other regions of the country, and the previously suggested existence of cryptic diversity within the taxon should be evaluated. Therefore, we suggest further integrative analyses to investigate a possible subspecific status of some Colombian populations.
Transcontinental 2200 km migration of a Nathusius’ pipistrelle (Pipistrellus nathusii) across Europe
Authors: Alcalde Juan Tomás , Jiménez Montserrat , Brila Ilze , Vintulis Viesturs , Voigt Christian C. , Pētersons Gunārs 
Published: October 2020

Abstract
A male Pipistrellus nathusii ringed in Pape Natural Park (S Latvia) in August 2015 was recovered recently dead in Pitillas’ Lagoon Natural Reserve (N Spain) in March 2017. At 2224 km in SSW direction, this is the first documented bat migration between these countries and worldwide the longest migration record of a bat. We also report other observations of this species in autumn in Northern Spain, suggesting that the Iberian Peninsula may be an important wintering area for Nathusius’ pipistrelles. Conservation measures should be agreed on by countries along the migration routes to improve the protection of this species.
Results on nonlocal stochastic integro-differential equations driven by a fractional Brownian motion
Authors: Issaka Louk-Man , Diop Mamadou Abdoul , Hmoyed Hasna 
Published: October 2020

Abstract
This paper deals with the existence of mild solutions for a class of non-local stochastic integro-differential equations driven by a fractional Brownian motion with Hurst parameter

H
∈

1
2

,
1

H\in \left(\tfrac{1}{2},1\right)

. Discussions are based on resolvent operators in the sense of Grimmer, stochastic analysis theory and fixed-point criteria. As a final point, an example is given to illustrate the effectiveness of the obtained theory.
Scaling capacity of fiber-optic transmission systems via silicon photonics
Authors: Shi Wei , Tian Ye , Gervais Antoine 
Published: October 2020

AbstractThe tremendous growth of data traffic has spurred a rapid evolution of optical communications for a higher data transmission capacity. Next-generation fiber-optic communication systems will require dramatically increased complexity that cannot be obtained using discrete components. In this context, silicon photonics is quickly maturing. Capable of manipulating electrons and photons on the same platform, this disruptive technology promises to cram more complexity on a single chip, leading to orders-of-magnitude reduction of integrated photonic systems in size, energy, and cost. This paper provides a system perspective and reviews recent progress in silicon photonics probing all dimensions of light to scale the capacity of fiber-optic networks toward terabits-per-second per optical interface and petabits-per-second per transmission link. Firstly, we overview fundamentals and the evolving trends of silicon photonic fabrication process. Then, we focus on recent progress in silicon coherent optical transceivers. Further scaling the system capacity requires multiplexing techniques in all the dimensions of light: wavelength, polarization, and space, for which we have seen impressive demonstrations of on-chip functionalities such as polarization diversity circuits and wavelength- and space-division multiplexers. Despite these advances, large-scale silicon photonic integrated circuits incorporating a variety of active and passive functionalities still face considerable challenges, many of which will eventually be addressed as the technology continues evolving with the entire ecosystem at a fast pace.