bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMIKIRAN ISLAM DALAM PEMBENTUKAN NASIONALISME INDONESIA: SEBUAH ANALISIS SEJARAH HUKUM
Authors: Wasitaatmadja Fokky Fuad 
Published: May 2020

ABSTRAK Kajian tentang nilai-nilai islam dan kaitannya dengan pembentukan kesadaran nasionalisme menjadi menarik untuk dikaji karena: peran ulama dan para pejuang muslim tersebut tidak lepas dari semangat untuk keluar dan lepas dari penjajahan. Peran para pejuang Islam baik yang berjuang secara fisik maupun yang berjuang dengan pemikiran melalui pena perlu dikaji untuk mengetahui secara historis peran ulama yang sangat penting dalam pencapaian kemerdekaan dan pembentukan Negara Kesatuan Republik Indonesia. Rumusan masalah dalam penelitian ini adalah: bagaimanakah gagasan pembentukan kesadaran kebangsaan para tokoh bangsa ditinjau dari sisi sejarah hukum? Metode penelitian yang digunakan adalah metode hukum normatif dengan pendekatan sejarah hukum. Teori yang digunakan dalam penelitian ini adalah teori sejarah hukum yang dikembangkan oleh Karl von Savigny. Kesimpulan penelitian yang diperoleh adalah: pemikiran K. von Savigny yang melihat sebuah perubahan dari bentuk yang primitif menuju sebuah bentuk modern juga terlihat dalam proses pembentukan kesadaran nasionalisme Indonesia.
ABSTRACT The study of Islamic values and their relation to the formation of nationalism awareness is interesting to study because: the role of the ulama and Muslim warriors is inseparable from the spirit to get out and escape from colonialism. The role of Islamic fighters, both those who struggle physically and those who struggle with ideas through a pen, needs to be examined to find out historically the role of the ulema which is very important in the achievement of independence and the formation of the Unitary State of the Republic of Indonesia. The formulation of the problem in this study is: how is the idea of forming national awareness among national figures in terms of the history of law? The research method used is a normative legal method with a historical approach to law. The theory used in this study is the theory of legal63 history developed by Karl von Savigny. The conclusions of the research obtained are: K. von Savigny's thought which saw a change from primitive to modern patterns was also seen in the process of shaping Indonesian nationalism awareness.
MENCOBA MENGANALISIS TEORI SOSIOLOGI KLASIK DURKHEIM DI DUSUN X DESA Y KABUPATEN Z PROPINSI O
Authors: Hendra Djaja 
Published: May 2020

ABSTRAK Teori Durkheim dalam sosiologi klasik Perancis terkenal dengan tekanannya pada norma-norma kolektif yang mempengaruhi tindakan dan kehidupan individu-individu, tanpa siapa pun yang menyadarinya. Isu-isu kolektif tersebut begitu kuat mengikat, sehingga telah menjadi ciri-ciri khas di dalam hubungan sosial yang bersangkutan. Dari sinilah, kemudian masyarakat itu hidup dalam bermasyarakat maupun bernegara. Teori Durkheim akan dicoba untuk diterapkan di Dusun X, Desa Y, Kabupaten Z, Provinsi O. Hasil-hasil observasi partisipan, terbukti: memang terlihat betapa norma-norma kolektif itu begitu kuat-mengikat individu-individu, sehingga warga pun tidak kuasa secara terang-terangan untuk menolak dari norma-norma yang sudah ditetapkan. Masyarakat Dusun X, tinggal mematuhi dan menerapkan di dalam kehidupan sehari-hari tanpa melihat, apakah norma-norma tersebut sudah sesuai atau tidak dari kehidupan masyarakat yang bersangkutan. Akibatnya, masyarakat Dusun X telah kehilangan kemandirian, jati-diri dan kreativitasnya; atau jika berniat mencoba untuk melawan norma-norma yang telah ditetapan, maka dengan sangat terpaksa siap-siap untuk meninggalkan dusun tempat kelahirannya. Penyebab utama adalah, faktor kemiskinan dikarenakan pekerjaan yang dilakukan sebagian besar tukang becak, buruh bangunan dan sawah hanya sebatas untuk makan sampai pada panen berikutnya. Solusinya, memberi pengertian yang mendalam dan intensif kepada tokoh-tokoh masyarakat yang ada di Dusun X.
ABSTRACT Durkheim theory on French classical Sociology is well known with its pressure with the collective norms that affect the action and the life of individuals, without anyone realized it. Those collective issues were tightly bounded, so it has become the special characteristic in the related social relation. From here, then the citizens live in society and in the living state. Durkheim theory will be tried to be applied on X backwoods, Y village, Z province and O province. The result of participants’ observation resulted: it is seen that collective norms tightly tied individuals, so that people do not have the right directly to refuse the stated norms. The citizens of X backwoods, obey and apply the norms in the daily live without seeing whether the norm is appropriate for the live of the related people or not. As the result, citizen from X orchard has lost their independence, self identity and creativity; or if they have a willing to try to break the stated norm, as the result they have to be forced to leave the place where they were born. The main factor is poverty, it is because the job that are done mostly are pedicab drivers, building labor and field worker and it is only enough to earn money on food until the next harvest. The solution of this problem is giving a depth and intensive understanding to the prominent figure in X backwoods.
Editorial: Transfigurasi dan Aksentuasi Jurnal di Tahun 2020
Authors: Abdillah Fauzi 
Published: May 2020

Para pembaca yang budiman, Jurnal Ilmiah Mimbar Demokrasi menerbitkan artikel hasil penelitian, artikel gagasan, dan ulasan buku yang termasuk pada ruang lingkup kajian disiplin ilmu Pendidikan Pancasila dan Kewarganegaraan (PPKn). Saat ini Jurnal Ilmiah Mimbar Demokrasi secara online telah terindeks pada Google Scholar, Portal Jurnal Garuda, Crossref, Sinta dan lain sebagainya.
Pada tahun 2019, melalui Surat Keputusan No. 36/E/KPT/2019 yang dikeluarkan oleh Direktur Jenderal Penguatan Riset dan Pengembangan Kementerian Riset, Teknologi, dan Pendidikan Tinggi (Kemenristekdikti), telah menyatakan bahwa Jurnal Ilmiah Mimbar Demokrasi telah terakreditasi pada peringkat Sinta 5 mulai Volume 17 No. 1 2018 sampai Volume 21 No. 2 tahun 2022.
Editorial kali ini juga dimanfaatkan sebagai media informasi bahwa telah terjadi transfigurasi atau perubahan pada beberapa aspek di Jurnal Ilmiah Mimbar Demokrasi. Perubahan pertama adalah pergantian dan perubahan susunan Dewan Editor atau Editorial Boards dan Reviewers atau Mitra Bestari. Perubahan susunan dan penambahan Editor maupun Reviewer dilaksanakan dengan pertimbangan kepakaran, jejak publikasi, dan mengoptimalkan peran asosiasi profesi untuk berkontribusi pada proses penerbitan jurnal.
Mechanism of LIN28B in trophoblastic villous cells of unexplained recurrent abortion
Authors: Huang QiaoYao , Niu YanRu , Song LiJun , Huang JinZhi , Wang Chenxi , Ma Tianzhong 
Published: May 2020

Abstract
LIN28B plays an important role in early embryonic development, but its role in villous trophoblast implantation and differentiation remains unknown. Purpose: To verify the role of LIN28B in trophoblastic villous tissue and cells from women with URSA(unexplained recurrent spontaneous abortion)and artificial termination of pregnancy (negative control, NC). Methods:The Lin28b gene and its protein expression level were detected with real-time quantitative PCR, Western immunoblotting analysis, and immunocytochemistry. The gene was also overexpressed in chorionic villous cell lines (HTR-8/SVneo and BeWo) to examine its effect on trophoblast function. Results: The expression of LIN28B mRNA and protein of URSA villi was lower than that in the NC group. At the cellular level, overexpression of LIN28B enhanced cellular migration, and invasion, and inhibited apoptosis. LIN28B may inhibit apoptosis by promoting Akt phosphorylation and by inhibiting Bad phosphorylation and Bcl-2 expression. In addition, LIN28B inhibited cell fusion and reduced cellular syncytia. Conclusions: LIN28B can inhibit cell proliferation, invasion and migration in vitro, and promote apoptosis and fusion. The low expression of LIN28B in URSA villous trophoblast cells may be one of the causes of abortion. The role of LIN28B in villous trophoblasts needs further study.
Based on HPA axis to explore the mechanism of waist-rubbing therapy in the treatment of lumbar disc herniation model rats
Authors: Qin Yuhang , Lin Facai , Wu Yunchuan , Xiong Ying , Sun Guanghan 
Published: May 2020

Abstract
Background

lumbar disc herniation (LDH) is a high-risk species in the world with serious harm. Traditional Chinese Tuina is the first choice in the treatment of LDH. In the past clinical studies, we have achieved good results in the treatment of LDH with the waist-rubbing method recorded in an ancient Chinese medical book of Qing Dynasty. Now we further explore its internal mechanism of action from the perspective of animal experiments. Waist-rubbing is a frictional heat-generating stimulus that acts on the surface of the skin. It does not relieve the compression in spinal canal, but can effectively eliminate the symptoms of LDH patients. This suggests that waist-rubbing may play a therapeutic role by interfering the autoimmunity of LDH. For a long time, the treatment of LDH mainly focused on how to relieve the mechanical compression caused by lumbar disc herniation, but little attention was paid to the autoimmune inflammation of LDH. In this study, from the point of view of regulating LDH's autoimmunity, the waist-rubbing method was taken as the treatment measure, and the lumbar strain rats in upright position were taken as the model. The neuroendocrine immunology mechanism of waist-rubbing method in treating LDH was revealed, which provided new ideas and scientific basis for Tuina clinical treatment of LDH, and also provided strong evidence for the theory of LDH's autoimmunity.
Methods

30 SD rats were randomly divided into three groups of the blank, the model and the waist wiping. The LDH model of the forelimb-free standing rats was established. Each group was treated according to the corresponding method. The waist-rubbing group was treated once a day for 15 days. After the experiment, the blood and lumbar spinal cord samples were collected after rats been killed. The contents of the CRH(Corticotropin releasing hormone), ACTH(Adrenocorticotropic hormone), CORT(Cortisol), IL-17(Interleukin-17), IL-6(Interleukin-6), TGF-β1(Transforming growth factor-β1) and IL-10(Interleukin-10) in peripheral blood and the GRα(Glucocorticoid receptor α) and 5-HT1A(Five hydroxytryptamine 1A) receptor in L4-L6 segment of rat lumbar spinal cord were detected by ELISA(Enzyme-linked immunoSorbent assay).
Results

Compared with the blank group, the contents of CRH, ACTH, CORT, GRα, 5-HT1A receptor, TGF-β1 and IL-10 in the model group were significantly decreased (P < 0.05), while the contents of IL-17 and IL-6 were significantly increased (P < 0.05). Compared with the model group, the contents of CRH, ACTH, CORT, GRα, 5-HT1A receptor, TGF-β1 and IL-10 in the waist-rubbing group were significantly increased (P < 0.05), while the contents of IL-17 and IL-6 were significantly decreased (P < 0.05).
Conclusion

The waist-rubbing method may eliminate the autoimmune inflammatory reaction of LDH by correcting the hypofunction of HPA axis, so as to achieve the therapeutic effect of LDH.
Long non-coding RNA NEAT1 aggravates epilepsy and seizure-induced neuronal damage by regulating microRNA-139/ROCK1 axis
Authors: Li Xiaowan , Hao Fang , Tao Shuxin , Wang Weihua , Xiao Xinxing , Guo Dong , Ma Hongling , Liu Xuewu 
Published: May 2020

Abstract
Background

Both long non-coding RNA (lncRNA) NEAT1 and microRNA (miR)-139 are crucial gene regulators in various disorders. This study aims to investigate their role in epilepsy and seizure-induced neuronal damage.
Methods

In this research, rat model of epilepsy was established by pilocarpine induction. The RNA and protein expression in hippocampal tissues and neurons were determined by RT-qPCR and Western blot analysis, respectively. Microarray analysis was used to predict the relationship between NEAT1 and miR-139 or between miR-139 and ROCK1, and dual luciferase reporter gene assay was performed to verify the interaction. The endogenous expression of related genes was modulated by recombinant plasmids and cell transfection. The cell apoptosis, levels of inflammatory factors and cell proliferation were detected by flow cytometry, ELISA and EdU assay.
Results

LncRNA NEAT1 and ROCK1 was upregulated, while the miR-139 was downregulated in hippocampal tissues and neurons of epileptic rats. Overexpression of NEAT1 decreased the activity of neurons, increased cell apoptosis, and increased the level of inflammatory factors. NEAT1 negatively targeted miR-139 to upregulate ROCK1. The RhoA/ROCK1 signaling pathway was activated by NEAT1 overexpression and miR-139 downregulation.
Conclusion

LncRNA NEAT1 suppressed pilocarpine-induced epilepsy by inhibiting apoptosis of hippocampal neurons through miR-139/RhoA/ROCK1 axis, and thereby inhibiting neuronal injury induced by seizure.
Gender-based Inequalities in Health literacy among an Iranian Kurd Population: Results of a Community Survey
Authors: Mahmoodi Hassan , Moradzadeh Rahmatollah , Iranpour Abedin , Shahi Fatemeh , Azimi Somayeh , Saqqezi Pershang Sharifi , Keshavarzian7 Khadijeh , Shirzadi Shayesteh , Hosking Sarah , Nadrian Haidar 
Published: May 2020

Abstract
Background Health literacy (HL) as a social determinant of health has a determinant role in providing different populations with healthcare services, in an equal manner. Our aim in this study was to investigate the contribution of socio-demographic factors to functional health literacy (FHL) in a population of Iranian adults and identify differences in the contribution of these factors across genders.Methods This community-based cross-sectional study was conducted in 2015 to 2016 in Sanandaj, Iran. Multistage cluster sampling was employed to recruit 1000 people older than 18 (response rate = 89.2%) from 35 urban and 10 rural health care centers through home-based interviews. Test of functional health literacy in adults (TOFHLA) was used to assess FHL. In order to measure inequality in FHL, a concentration index decomposition was used.Results Participants included 869 respondents (57.5% women) with a mean age of 33.68 year. Participants demonstrated an average TOFHLA score of 51.9. Women demonstrated slightly higher TOFHLA scores (52.2 [SD: 0.46]) compared to men (50.7 [SD: 0.4]). However, the concentration index for gender was 10.9% suggesting gender contributed only moderately to TOFHLA scores. Comparatively, 54.3% of TOFHLA differences were attributed to geographic location. Among women, place of residence, monthly income age, education level, being head of household, and contributed to 43%, 32%, 13%,11.5% and 11%, of FHL inequality, respectively. Among men, however, place of residence (45.2%) size of household (15.1%), and monthly income (13.5%) contributed most to inequality in FHL.Conclusions This research suggests sociodemographic characteristics contributed differently to FHL inequality depending on gender. Understanding these differences may assist in identifying and targeting interventions towards men and women with low levels of FHL. Furthermore, work by health policy makers and health promotion specialists to address these contributing social factors may help to alleviate inequalities in health literacy.
A mixed-method comparison of physician-reported beliefs about and barriers to treatment with medications for opioid use disorder
Authors: Haffajee Rebecca , Andraka-Christou Barbara , Attermann Jeremy , Cupito Anna , Buche Jessica , Beck Angela J. 
Published: May 2020

Abstract
Background Evidence demonstrates that medications for treating opioid use disorder (MOUD) —namely buprenorphine, methadone, and extended-release naltrexone—are effective at treating opioid use disorder (OUD) and reducing associated harms. However, MOUDs are heavily underutilized, largely due to the under-supply of providers trained and willing to prescribe the medications. Methods: To understand comparative beliefs about MOUD and barriers to MOUD, we conducted a mixed-methods study that involved focus group interviews and an online survey disseminated to a random group of licensed U.S. physicians, which oversampled physicians with a preexisting waiver to prescribe buprenorphine. Focus group results were analyzed using thematic analysis. Survey results were analyzed using descriptive and inferential statistical methods.Results Study findings suggest that physicians have higher perceptions of efficacy for methadone and buprenorphine than for extended-release naltrexone, including for patients with co-occurring mental health disorders. Insurance obstacles, such as prior authorization requirements, were the most commonly cited barrier to prescribing buprenorphine and extended-release naltrexone. Regulatory barriers, such as the training required to obtain a federal waiver to prescribe buprenorphine, were not considered significant barriers by many physicians to prescribing buprenorphine and naltrexone in office-based settings. Nor did physicians perceive diversion to be a prominent barrier to prescribing either buprenorphine or extended-release naltrexone. In focus groups, physicians identified financial, logistical, and workforce barriers—such as a lack of addiction treatment specialists—as additional barriers to prescribing medications to treat OUD.Conclusions Additional education is needed for physicians regarding the comparative efficacy of different OUD medications. Governmental policies should mandate full insurance coverage of and prohibit prior authorization requirements for OUD medications.
Examining the theoretical relationships between constructs in the person-centred practice framework: a structural equation model.
Authors: McCance Tanya , McCormack Brendan , Slater Paul , McConnell Donna 
Published: May 2020

Abstract
Background Research relating to Person-centred practice continues to expand and currently there is a dearth of statistical evidence that tests the validity of an accepted model of person-centred practice. The Person-centred Practice Framework is a leading model of practice and this study aims to examine it statistically.Methods A cross sectional survey design using a standardized tool was used to assess a purposive sample (n=1283, 31.8%) of multi-disciplinary health professionals across both Northern and Southern Ireland. Survey items scores were summed to provide construct scores and included in a structural model to examine the theoretical model of person-centred practice. Full ethical approval was gained. Results The results were drawn from a multi-disciplinary sample, and representing a broad range of clinical settings. The model explains 60.5% of the total variance. Factor loadings on to the second order latent construct, and fit statistics confirm the acceptability of the measurement model. Statistically significant factor loadings were acceptable. A positive and statistically significant relationship was observed between prerequisites and care environment as well as care processes.Conclusions The study provides statistical evidence to support the Person-centred Practice Framework, with a multidisciplinary sample. The findings help confirm the effectiveness of the PCPI-S and an instrument to measure an internationally renowned model of Person-centred practice.
Computational Identification of miRNAs and Temperature Responsive lncRNAs from Mango (Mangifera indica, L.)
Authors: Moh Nann Miky Moh , Zhang Peijing , Chen Yujie , Chen Ming 
Published: May 2020

Abstract
Background

Mango is a major tropical fruit in the world and is known as the king of fruits because of its flavour, aroma, taste, and nutritional values. Moreover, various parts of mango trees have been used for medical purposes. Although various regulatory roles of miRNAs and lncRNAs have been investigated in many plants, there is yet an absence of study in mango. This is the first study to provide information on ncRNAs of mango with the aim of identifying miRNAs and lncRNAs of mango and discovering of their potential functions by the interaction prediction of the miRNAs, lncRNAs and their target genes.
Results

In this analysis, 104 miRNAs and 7,610 temperature responsive lncRNAs were identified and the target genes of these ncRNAs were characterized. By analysing the interaction of miRNAs and their target genes, it was observed that miRNAs are mainly involved in growth, development, and stress responses of mango. For the lncRNAs, cold responsive lncRNAs bound to low temperature responsive proteins expressed at low temperature stress. GO enrichment analysis of heat and cold responsive lncRNAs revealed that they involved in all three basic processes; biological process, cellular component, and molecular function. Moreover, mango lncRNAs can target miRNAs to reduce the stability of lncRNAs and can function as molecular decoys or sponges of miRNAs.
Conclusion

This paper would provide the new information about miRNAs and lncRNAs of mango and would help for the further investigation of mango ncRNAs.
WDPCP modulates cilia beating through MAPK/ERK pathway in chronic rhinosinusitis
Authors: Ma Yun , Tian Peng , Zhong Hua , Wu Fan , Zhang Qining , Liu Xiang , Dang Hua , Chen Qiujian , Zou Hua , Zheng Yiqing 
Published: May 2020

Abstract
Background: Cilia loss and dysfunction is one of the typical pathological features of chronic rhinosinusitis. Tryptophan-aspartic acid (W-D) repeat containing planar cell polarity effector (WDPCP) has been proven to be an essential element for ciliogenesis in human nasal epithelium, but its role in the beating of cilia remains unclear. Cilia beating requires energy from the mitochondria, which is regulated by the MAPK/ERK pathway. In this study, we sought to investigate the role of WDPCP and its underlying mechanism behind the dysfunction in the beating of cilia in chronic rhinosinusitis.Methods: We demonstrated WDPCP expression in the epithelium of nasal polyps. We also investigated the MAPK/ERK pathway in primary human sinonasal epithelial cells to explore the function of WDPCP. The air-liquid interface culture system was used as a model to verify the role of WDPCP and the MAPK/ERK pathway in the beating of cilia.Results: With the dysfunction of cilia beating, we observed a low expression of WDPCP in the epithelium of nasal polyps. Within the in vitro study, we found that WDPCP was critical for mitochondrial biogenesis and mitochondrial function in human sinonasal epithelial cells, possibly due to the activation of the MAPK/ERK pathway. The mitochondrial dysfunction caused by U0126 or lacking WDPCP could be partially recovered by dexamethasone.Conclusion: The low expression of WDPCP in nasal epithelium could affect mitochondria via the MAPK/ERK pathway, which may contribute to the dysfunction in the beating of cilia in chronic rhinosinusitis.