bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical value and usage of inflammatory and nutritional markers in survival prediction for gastric cancer patients with neoadjuvant chemotherapy and D2 lymphadenectomy
Authors: Li Ziyu , Li Shuangxi , Ying Xiangji , Zhang Lianhai , Shan Fei , Jia Yongning , Ji Jiafu 
Published: February 2020

Abstract
Background
The clinical values of inflammatory and nutritional markers remained unclear for gastric cancer with neoadjuvant chemotherapy (NACT).

Methods
The inflammatory, nutritional markers and their changes were analyzed for locally advanced gastric cancer with NACT. The predictive value was evaluated by the Cox proportional hazards regressions under three hypothesized scenarios. The nomograms including independent prognostic factors were plotted for survival prediction.

Results
A total of 225 patients were included in the study. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index, and hemoglobin (Hgb) were significantly reduced, and the body mass index was significantly increased after NACT (all P < 0.05). The pre-NACT NLR [hazard ratio (HR) = 1.176, P = 0.059] showed a trend to correlate with the overall survival (OS) when only pre-NACT markers available; The post-NACT Hgb (HR = 0.982, P = 0.015) was the independent prognostic factor when only post-NACT markers available; The post-NACT Hgb (HR = 0.984, P = 0.025) and the change value of LMR (HR = 1.183, P = 0.036) were the independent prognostic factors when both pre- and post-NACT markers available. The nomogram had a similar Harrell’s C-statistic compared to ypTNM stage (0.719 vs. 0.706).

Conclusion
For locally advanced gastric cancer, the NACT could significantly decrease some inflammatory markers. The pre-NACT NLR, the post-NACT Hgb and the change value of LMR had some values in survival prediction combined with age, sex, tumor location and the clinical stages under different clinical scenarios. The elevated initial NLR, the preoperative anemia and the greater change value of LMR implied a poor prognosis.
Factors Associated with Attrition: Analysis of an HIV Clinic in Japan
Authors: Hashiba Chieko , Imahashi Mayumi , Imamura Junji , Nakahata Masashi , Kogure Ayumi , Takahashi Hideto , Yokomaku Yoshiyuki 
Published: February 2020

AbstractThis study evaluated the impact of a public medical interpreter on the follow-up clinic attendance rate of foreign-born people with HIV who live in Japan. Participants were patients who visited Nagoya Medical Center from 2009 to 2016. Lost to follow-up was defined as an absence from follow-up visits for more than six months without any notification. A log-rank test was conducted to compare the lost-to-follow-up rates by patients’ nation of origin and medical interpreter use. Of the 931 participants, 114 were foreign patients, whose overall attendance rate at 5 years was 75.5%, which was significantly lower than that of Japanese patients (94.1%, p < 0.001). There was no significant difference in regular attendance with respect to medical interpreter use (p = 0.09). Social support in addition to a medical interpreter may be needed to improve attendance rates in the study population.
Dynamic absolutism and qualitative change
Authors: Eker Bahadır 
Published: February 2020

AbstractAccording to Fine’s (Modality and tense: philosophical papers. Oxford University Press, Oxford, pp 261–320, 2005) famous take on the infamous McTaggartian paradox, realism about tensed facts is incompatible with the joint acceptence of three very general and seemingly plausible theses about reality. However, Correia and Rosenkranz (As time goes by: eternal facts in an ageing universe. Mentis, Paderborn, 2011) have recently objected that Fine’s argument depends on a crucial assumption about the nature of tensed facts; once that assumption is given up, they claim, realists can endorse the theses in question without further ado. They also argue that their novel version of tense realism, called dynamic absolutism, is to be preferred over its rivals. I argue in this paper that dynamic absolutism does not constitute a genuine alternative for realists about tense.
Ecosystem services potential for climate change resilience in peri-urban areas in Sub-Saharan Africa
Authors: Mngumi Lazaro Eliyah 
Published: February 2020

AbstractEcosystem services provide considerable development opportunities, including incorporating land use planning and enhancing climate change resilience in peri-urban communities. However, the application of this concept in planning and enhancing climate change resilience is negligible in Sub-Saharan Africa (SSA). This article reviews state-of-the-art research on the potential contribution of peri-urban ecosystem services to climate change resilience in SSA and identifies research gaps for further work. This study was conducted through systematic review of articles from the Web of Science. The literature shows limited knowledge on peri-urban ecosystem services research globally and SSA in particular. The gaps in this knowledge stem from inadequate conceptualization and lack of understanding about how such knowledge can be translated into policy, planning and management and, hence, realizing development goals. In nutshell, the potential for climate change resilience of well-managed peri-urban ecosystem services includes reducing the physical exposure of peri-urban areas to floods and droughts and minimizing climate change risks through increased socio-economic resilience to hazard impacts and provision of the carbon sequestration function. However, specific peri-urban studies describing ecosystem service types and how they can be synchronized into mainstream urban planning and climate change resilience strategies are lacking in most SSA urban regions/landscapes. Therefore, case studies need to be conducted to contextualize and downscale the concept in peri-urban areas and to determine how the concept can be synchronized into broad urban planning and strategies for enhancing resilience to climate change in vulnerable urban and peri-urban communities.
Understanding the Prevalence and Situational Characteristics of Hostage and Crisis Negotiation in England: an Analysis of Pilot Data from the National Negotiator Deployment Database
Authors: Grubb Amy Rose 
Published: February 2020

AbstractThe following paper outlines the findings from an exploratory analysis of the hostage and crisis negotiator deployment database that was piloted within Norfolk and Suffolk Constabularies prior to national rollout of a centralised and standardised online recording mechanism for negotiator deployments across the majority of police forces within the UK. The research utilised a descriptive research design, whereby the secondary data from an initial 24-month recording period was analysed using descriptive statistics. The findings provide a descriptive representation of (1) the socio-demographic characteristics of the subjects encountered by negotiators, (2) the typical situational characteristics/circumstances in which subjects present and the most frequently encountered subject impact factors and (3) how hostage/crisis incidents are typically resolved. The findings are discussed with relevance to the implications for negotiator practice and policy. An emphasis is placed on identification of recommendations for improving the discipline of hostage and crisis negotiation via the standardisation of deployment recording and targeted/focused training and continuing professional development of negotiators based on the characteristics of deployments observed.
Die AfD ist (mittlerweile) eine rechtsextremistische Partei
Authors: Pfahl-Traughber Armin 
Published: February 2020

ZusammenfassungDie „Alternative für Deutschland“ (AfD) hat sich mittlerweile zu einer rechtsextremistischen Partei entwickelt, wofür zahlreiche Aussagen von führenden Funktionsträgern gegen die Grundlagen moderner Demokratie und offener Gesellschaft sprechen.
Current state and perspectives of checkpoint inhibitors in ovarian cancer treatment
Authors: Bartl Thomas , Paspalj Valentina , Polterauer Stephan , Grimm Christoph 
Published: February 2020

SummaryThe introduction of checkpoint inhibitors (CPI) has set a paradigm shift within the therapies for a variety of advanced solid tumors. By altering key regulators of cellular immune response, so-called immune checkpoints, CPIs modulate peripheral cancer immune tolerance to induce cancer-targeted immune reactions. Response rates, however, vary significantly between different solid tumor types. A certain efficacy of CPIs has been described for gynecological malignancies, as the KEYNOTE-028 study reported an objective response rate (ORR) of 13.0% (95% confidence interval [CI] 2.8–33.6) for endometrial and the CheckMate-358 study an ORR of 26.3% (95% CI 9.1–51.2) for cervical cancer. With respect to epithelial ovarian cancer (EOC), recent evidence suggests only modest response, as the largest study to date by Matulonis et al. reported in 2019 that pembrolizumab induced an ORR of only 8.0% in 376 patients with EOC. Thus, latest clinical data indicate EOC to be rather “immunologically cold”, most likely due to both an inherently low tumor mutational burden (TMB) and a subsequently limited cellular antigen presentation. As CPI monotherapy therefore seems to be of limited clinical significance, ongoing clinical trials moved to combine CPI with PARP inhibitors and/or with antiangiogenic agents to elucidate possible synergistic antitumoral effects of these combinations. Despite promising preliminary data, the large phase 3 trials are still ongoing. To date, CPI monotherapy in OC remains highly experimental and is only to be administered within clinical studies and a highly selected group of patients.
On the Outskirts of the Charmed Circle—Challenges and Limitations of Sexual Health Promotion to Young People in Secure State Care
Authors: Lindroth Malin 
Published: February 2020

AbstractObjectivesYoung people on the verge of, or in, secure state care or incarceration have reduced general and sexual health. The promoting of sexual health among young people in secure state care is therefore a responsibility for both the state-run agency responsible for this care and for the professionals who work there.MethodsThis position paper discusses sexual and reproductive health and rights (SRHR) for young people in secure state care in Sweden. Four previous studies on sexual health of young people in secure state care are revisited, and governmental policy documents are examined.ResultsYoung people in secure state care face many threats to their sexual and reproductive health and rights. Some of these threats originate with the institutional placement itself and the lack of knowledge among the staff. Clashes on various levels between the subjectively desired (young people seeking pleasure from sex, alcohol, or other drugs) and the societally desired (sexual health, minimal alcohol use, and no drug use among young people) are described. In addition, clashes are seen between young people who want to be like everyone else in their social context and the staff with a mission (i.e. job description) to readjust young people into adopting socially accepted behaviour.ConclusionI argue that young people in secure state care have sexual experiences that are marginalized and placed on the outskirts of the charmed (sexual) circle of societally accepted sexual behaviour. In addition, their experiences are surrounded by silence, a silence sustained by both young people and professionals. The readiness of professionals to handle SRHR for young people in secure state care in a knowledge-based and non-judgemental fashion is crucial. Future research should focus on this readiness and have the needs and wishes of young people as its departing point. Although the article involves a local context, it may be of interest to a wider audience, as the placement of young people in secure state care and other forms of incarceration occurs worldwide.
Experimental study of the relationship between porosity and surface area of carbonate reservoir rocks
Authors: Mohammadi Milad , Shadizadeh Seyed Reza , Manshad Abbas Khaksar , Mohammadi Amir H. 
Published: February 2020

AbstractOver the time by increasing global demand for source of energy and decreasing hydrocarbon production from reservoirs, recovery methods have become important. The surface area and porosity are central physical characteristics that highly affect the estimation of original oil and gas in place and understanding the mechanisms incorporating in production. The surface area is the internal surface area per unit of pore volume and determines the amount of space in rocks exposed to injectant during injection operation. The occurrence of fractures system in carbonated reservoirs increases the complexity and decreases the homogeneity; hence, it is difficult to determine the correct surface area of reservoir. Therefore, the existence of a local correlation which relates effective porosity to specific surface area is needed and it can help to estimate effective surface area exposed to chemicals during Enhanced Oil Recovery (EOR) process. In this study, the specific surface area in carbonate reservoir rocks was measured by gas adsorption (nitrogen) method and petro-graphical image analysis. In addition, the effective porosity was determined by a gas porosimeter, followed by plotting specific surface area measured by the Brunauer, Emmett and Teller (BET) method versus specific surface area determined from core scan and calibration curve. According to this calibration curve, a new relationship was developed (with R2 = 0.92) that could give BET data for a known data of core scan. The relationship between porosity and specific surface area was analyzed statistically and a relationship with accuracy of R2 = 0.89 was proposed. This relationship was compared with other models such as Pirson and Kotyakhov. Results show that the latter one is more accurate than other models and is more compatible with experimental data (with R2 = 0.84). The results obtained from the experiment indicate that the specific surface area shows an initial decrease upon increasing of porosity up to 0.2. After this decrease, the curve indicates an increasing trend. Moreover, a novel relationship was developed depending on the specific surface area, porosity and permeability and some constant parameters for carbonate rocks (with R2 = 0.95).
Microbe-induced fluid viscosity variation: field-scale simulation, sensitivity and geological uncertainty
Authors: Ansah Eric O. , Vo Thanh Hung , Sugai Yuichi , Nguele Ronald , Sasaki Kyuro 
Published: February 2020

AbstractThis study is intended to expand the scope of microbial enhanced oil recovery (MEOR) simulation studies from 1D to field scale focussing on fluid viscosity variation and heterogeneity that lacks in most MEOR studies. Hence, we developed a model that incorporates: (1) reservoir simulation of microbe-induced oil viscosity reduction and (2) field-scale simulation and robust geological uncertainty workflow considering the influence of well placement. Sequential Gaussian simulation, co-kriging and artificial neural network were used for the petrophysical modelling prior to field-scale modelling. As per this study, the water viscosity increased from 0.5 to 1.72 cP after the microbe growth and increased biomass/biofilm. Also, we investigated the effect of the various component compositions and reaction frequencies on the oil viscosity and possibly oil recovery. For instance, the fraction of the initial CO2in the oil phase (originally in the reservoir) was varied from 0.000148 to 0.005 to promote the reactions, and more light components were produced. It can be observed that the viscosity of oil reduced considerably after 90 days of MEOR operation from an initial 7.1–7.07 cP and 6.40 cP, respectively. Also, assessing the pre- and post-MEOR oil production rate, we witnessed two main typical MEOR field responses: sweeping effect and radial colonization occurring at the start and tail end of the MEOR process, respectively. MEOR oil recovery factors varied from 28.2 to 44.9% OOIP for the various 200 realizations. Since the well placement was the same for all realizations, the difference in the permeability distribution amongst the realizations affected the microbes’ transport and subsequent interaction with nutrient during injection and transport.
Mixed outcomes from conservation practices on soils and Striga-affected yields of a low-input, rice–maize system in Madagascar
Authors: Rodenburg Jonne , Randrianjafizanaka Meva Tahiry , Büchi Lucie , Dieng Ibnou , Andrianaivo Alain Paul , Ravaomanarivo Lala Harivelo Raveloson , Autfray Patrice 
Published: February 2020

AbstractOn upland soils in tropical Africa, common production constraints of rice and maize on smallholder farms are poor soil fertility—resulting from soil erosion and nutrient depletion—and infestation by witchweeds (Striga spp.). In Madagascar where these crops are often grown in rotation, combining legume cover crops with no-till and crop residue mulching—labelled conservation agriculture (CA)—may address these problems. Previously, it was shown that CA practices contribute to steep reductions in Striga asiatica infection. In the current study, a 4-year field experiment was conducted to test, for the first time, the hypothesis that CA practices also contribute to crop yield and soil improvements under Striga-infested conditions. The conventional mono-crop rice–maize rotation practice, involving seasonal tillage and crop residue removal, was compared to three rice–maize rotation systems following CA practices, each with a different legume cover crop option: (1) two short-cycle annual species, cowpea (Vigna unguiculata) and mucuna (Mucuna pruriens); (2) a long-cycle annual, ricebean (Vigna umbellata); and (3) a perennial, stylosanthes (S. guianensis). Rice yields, as well as yield variability, generally increased by changing from the conventional to a CA practice, and maize yields were variable and low in particular under the CA practices. CA practices significantly reduced soil displacement by rainwater runoff and increased soil nitrogen and pH levels (0–20 cm depth), in particular with stylosanthes as cover crop, but did not result in a significant change in soil organic carbon concentration. Rice yields correlated negatively with Striga asiatica plant numbers in years with moderate infection levels. This is the first study that shows mixed outcomes from CA practices in tropical cereal rotation systems on degraded, Striga-infested soils, and subsequent entry points for system improvements. Suggested improvements include judicious cover crop management, complementary fertilizer applications and selection of competitive, resistant and adapted crop varieties.
Collective Investment: Land, Crypto and Coin Schemes: Regulatory ‘Property’
Authors: Tjio Hans , Hu Ying 
Published: February 2020

AbstractThe UK Supreme Court held inAsset Land Plc v. FCA[2016] UKSC 17 that the land-banking scheme required authorization as a collective investment scheme in order to be sold to retail investors. This article critically analyses that decision in light of various approaches to regulating real estate investment trusts (‘REITs’) in the UK, Singapore, and Hong Kong, respectively. It considers the degree to which deference should be given to the views of the regulators, and the ramifications for other areas like initial coin offerings which regulators are increasingly seeing as securities requiring both prospectus disclosure for the token offering and intermediary regulation for its trading. It argues that the regulation of token offerings is both necessary and desirable. Regulation not only helps protect investors from fraudulent token issuers but also helps to fulfil other worthwhile goals, such as providing additional funding for small to medium-sized enterprises and financial inclusion.
A Molecular Foaming and Activation Strategy to Porous N-Doped Carbon Foams for Supercapacitors and CO2 Capture
Authors: Zhou Mengyuan , Lin Yaqian , Xia Huayao , Wei Xiangru , Yao Yan , Wang Xiaoning , Wu Zhangxiong 
Published: February 2020

Abstract
Hierarchically porous carbon materials are promising for energy storage, separation and catalysis. It is desirable but fairly challenging to simultaneously create ultrahigh surface areas, large pore volumes and high N contents in these materials. Herein, we demonstrate a facile acid–base enabled in situ molecular foaming and activation strategy for the synthesis of hierarchically macro-/meso-/microporous N-doped carbon foams (HPNCFs). The key design for the synthesis is the selection of histidine (His) and potassium bicarbonate (PBC) to allow the formation of 3D foam structures by in situ foaming, the PBC/His acid–base reaction to enable a molecular mixing and subsequent a uniform chemical activation, and the stable imidazole moiety in His to sustain high N contents after carbonization. The formation mechanism of the HPNCFs is studied in detail. The prepared HPNCFs possess 3D macroporous frameworks with thin well-graphitized carbon walls, ultrahigh surface areas (up to 3200 m2 g−1), large pore volumes (up to 2.0 cm3 g−1), high micropore volumes (up to 0.67 cm3 g−1), narrowly distributed micropores and mesopores and high N contents (up to 14.6 wt%) with pyrrolic N as the predominant N site. The HPNCFs are promising for supercapacitors with high specific capacitances (185–240 F g−1), good rate capability and excellent stability. They are also excellent for CO2 capture with a high adsorption capacity (~ 4.13 mmol g−1), a large isosteric heat of adsorption (26.5 kJ mol−1) and an excellent CO2/N2 selectivity (~ 24).
Draft whole-genome sequence of Brevibacterium casei strain isolated from a bloodstream infection
Authors: Olender Alina , Rutyna Paweł , Niemcewicz Marcin , Bogut Agnieszka , Ciesielka Marzanna , Teresiński Grzegorz 
Published: February 2020

AbstractDespite its low virulence potential and a commensal lifestyle as a member of the human skin microbiota, Brevibacterium casei has been increasingly reported as an opportunistic pathogen, especially in immunocompromised patients. Here, we present the draft genome sequence of the S51 strain isolated from a bloodstream infection. To the best of the authors’ knowledge, this is the first report of the draft genome sequence of the B. casei strain isolated from the clinical infection. The strain was identified using phenotypic and molecular methods and subsequently sequenced using the next-generation sequencing. The draft whole genome was assembled de novo, automatically annotated by Rapid Annotations using Subsystems Technology (RAST) server and scrutinized to predict the presence of virulence, resistance, and stress response proteins. The genome size of the S51 strain was 3,743,532 bp and an average G+C content was 68.3%. The predicted genes included 48 genes involved in resistance to antibiotics (including vancomycin, fluoroquinolones, and beta-lactams) and toxic compounds (heavy metals), 16 genes involved in invasion and intracellular resistance (Mycobacterium virulence operons), and 94 genes involved in stress response (osmotic, oxidative stress, cold and heat shock). ResFinder has indicated the presence of a beta-lactamase, and a phenotypic analysis showed resistance to penicillin. This whole-genome NGS project for the S51strain has been deposited at EMBL/GenBank under the accession no. QNGF00000000.