bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN): 12-Month Outcomes and Quality of Life After Brain Tumor Ablation
Authors: Kim Albert H , Tatter Steven , Rao Ganesh , Prabhu Sujit , Chen Clark , Fecci Peter , Chiang Veronica , Smith Kris , Williams Brian J , Mohammadi Alireza M , Judy Kevin , Sloan Andrew , Tovar-Spinoza Zulma , Baumgartner James , Hadjipanayis Constantinos , Leuthardt Eric C 
Published: February 2020

Abstract

BACKGROUND
Laser Ablation of Abnormal Neurological Tissue using Robotic NeuroBlate System (LAANTERN) is an ongoing multicenter prospective NeuroBlate (Monteris Medical) LITT (laser interstitial thermal therapy) registry collecting real-world outcomes and quality-of-life (QoL) data.

OBJECTIVE
To compare 12-mo outcomes from all subjects undergoing LITT for intracranial tumors/neoplasms.

METHODS
Demographics, intraprocedural data, adverse events, QoL, hospitalizations, health economics, and survival data are collected; standard data management and monitoring occur.

RESULTS
A total of 14 centers enrolled 223 subjects; the median follow-up was 223 d. There were 119 (53.4%) females and 104 (46.6%) males. The median age was 54.3 yr (range 3-86) and 72.6% had at least 1 baseline comorbidity. The median baseline Karnofsky Performance Score (KPS) was 90. Of the ablated tumors, 131 were primary and 92 were metastatic. Most patients with primary tumors had high-grade gliomas (80.9%). Patients with metastatic cancer had recurrence (50.6%) or radiation necrosis (40%). The median postprocedure hospital stay was 33.4 h (12.7-733.4). The 1-yr estimated survival rate was 73%, and this was not impacted by disease etiology. Patient-reported QoL as assessed by the Functional Assessment of Cancer Therapy-Brain was stabilized postprocedure. KPS declined by an average of 5.7 to 10.5 points postprocedure; however, 50.5% had stabilized/improved KPS at 6 mo. There were no significant differences in KPS or QoL between patients with metastatic vs primary tumors.

CONCLUSION
Results from the ongoing LAANTERN registry demonstrate that LITT stabilizes and improves QoL from baseline levels in a malignant brain tumor patient population with high rates of comorbidities. Overall survival was better than anticipated for a real-world registry and comparative to published literature.
On duality in $\mathcal{N}=2$ supersymmetric Liouville theory
Authors: Nakayama Yu 
Published: February 2020

Abstract
Similarly to the bosonic Liouville theory, the $\mathcal{N}=2$ supersymmetric Liouville theory was conjectured to be equipped with the duality that exchanges the superpotential and the Kähler potential. The conjectured duality, however, seems to suffer from a mismatch of the preserved symmetries. More than fifteen years ago, when I was a student, my supervisor Tohru Eguchi gave a beautiful resolution of the puzzle when the supersymmetry is enhanced to $\mathcal{N}=4$ based on his insight into the underlying geometric structure of the $A_1$ singularity. I will review his unpublished but insightful idea and present our attempts to extend it to more general cases.
Chronic diarrhoea and risk of rheumatoid arthritis: findings from the French E3N-EPIC Cohort Study
Authors: Nguyen Yann , Mariette Xavier , Salliot Carine , Gusto Gaëlle , Boutron-Ruault Marie-Christine , Seror Raphaèle 
Published: February 2020

AbstractObjectivesTo assess the relationship between gastrointestinal disorders and the risk of further development of RA.MethodsThe Etude Epidémiologique auprès des femmes de la Mutuelle générale de l’Education Nationale-European Prospective Investigation into Cancer and Nutrition Study is a French prospective cohort including 98 995 healthy women since 1990. Participants completed mailed questionnaires on their lifestyles and health-related information. Gastrointestinal disorders were assessed in the third questionnaire (sent in 1993). Hazard ratios and 95% CIs for incident RA were estimated using Cox proportional hazards regression models with age as the time scale. Models were age adjusted, and then additionally adjusted for known risk factors of RA such as smoking, and for potential cofounders.ResultsAmong 65 424 women, 530 validated incident RA cases were diagnosed after a mean (s.d.) of 11.7 (5.9) years after study baseline. In comparison with no gastrointestinal disorder, chronic diarrhoea was associated with an increased risk of developing RA during follow-up (hazard ratio = 1.70, 95% CI 1.13, 2.58), independently of dysthyroidism or dietary habits. The association was stronger among ever-smokers (hazard ratio = 2.21, 95% CI 1.32, 3.70). There was no association between RA risk and constipation or alternating diarrhoea/constipation.ConclusionChronic diarrhoea was associated with an increased risk of subsequent RA development, particularly among ever-smokers. These data fit with the mucosal origin hypothesis of RA, where interaction between intestinal dysbiosis and smoking could occur at an early stage to promote emergence of autoimmunity, followed years later by clinical disease.
The Progression and Ongoing Development of a Research Agenda for Faith Community Nursing
Authors: Solari-Twadell Phyllis Ann , Ziebarth Deborah Jean 
Published: February 2020

ABSTRACT:
Research is critical to the growth of professional nursing in every practice area. Faith community nursing research evolved slowly in the years following publication of the first research in 1989. A faith community nursing research agenda was developed in 2008 and research priorities have been reviewed every 2 years since 2012 at a forum held in conjunction with the annual Westberg Symposium. This article reviews the progression and ongoing development of a research agenda for the specialty practice of faith community nursing. Recommendations for the development of future research for faith community nursing are discussed.
Colocated Developmental-Behavioral Pediatrics in Primary Care: Improved Outcome Across Settings
Authors: Martin-Herz Susanne P. , Buysse Christina A. , DeBattista Anne , Feldman Heidi M. 
Published: February 2020

ABSTRACT:

Objective:
We developed a colocation “Rapid Developmental Evaluation” (RDE) model for Developmental-Behavioral Pediatrics (DBP) to evaluate young children for developmental concerns raised during routine developmental surveillance and screening in a pediatric primary care Federally Qualified Health Center (FQHC). In this low-income patient population, we anticipated that colocation would improve patient access to DBP and decrease time from referral to first developmental evaluation and therapeutic services.

Methods:
Children were assessed at the FQHC by a DBP pediatrician, who made recommendations for therapeutic services and further diagnostic evaluations. A retrospective chart review over 27 months (N = 151) investigated dates of referral and visit, primary concern, diagnosis, and referral to tertiary DBP center and associated tertiary DBP center dates of service and diagnoses if appropriate. We surveyed primary care clinicians (PCCs) for satisfaction.

Results:
The DBP pediatrician recommended that 51% of children be referred to the tertiary DBP center for further diagnostic evaluation or routine DBP follow-up. Average wait from referral to an RDE visit was 57 days compared with 137.3 days for the tertiary DBP center. Children referred from RDE to the tertiary DBP center completed visits at a higher rate (77%) than those referred from other sites (54%). RDE-recommended therapeutic services were initiated for 73% of children by the tertiary visit. Fidelity of diagnosis between RDE and the tertiary DBP center was high, as was PCC satisfaction.

Conclusion:
Colocation of a DBP pediatrician in an FQHC primary care pediatrics program decreased time to first developmental assessment and referral for early intervention services for an at-risk, low-income patient population.
INTRAPEC Technique Controls Pectoralis Spasm and Pain for Subpectoral Breast Implantation: A Retrospective Study
Authors: Kline Jonathan , Lee Wayne , Wofford Ken 
Published: February 2020

Background:
In 2018, a novel approach to reduce pectoralis spasm from sub- pectoral breast implant surgery was published called the INTRAPEC.1 In this study, we more formally examine the effectiveness of the ultrasound-guided INTRAPEC injection to control postoperative pectoralis major spasm and pain following breast surgery with sub-pectoral implantation.

Methods:
We employed a simple postoperative spasm and pain record to collect data on 17 patients, all of whom received INTRAPEC and erector spinae plane blocks as a part of an opioid- free anesthetic. All breast surgeries were completed with LMA general anesthesia, preserving spontaneous ventilation.

Results:
Of the 17 study participants, 13 (76.4%) reported spasm scores less than 3 for the entire 2-day study period and, at most time points, patients reported a median score for pain of 2, with IQRs ranging from 1 to 7.

Conclusions:
The study results suggest that the INTRAPEC injection is a simple, low-cost, low-risk, and effective technique that controls post- operative spasm following breast surgery involving sub-pectoral implantation.
Role of Oral Tramadol 50 mg in Reducing Pain During Colposcopy-Directed Cervical Biopsy: A Randomized Controlled Trial
Authors: Darweesh Fatma Faisal , Samy Ahmed , Mousa Abdalla Mohamed , Abdelbar Ahmed Tarek , Mahmoud Mostafa , Abdelhakim Ahmed Mohamed , Metwally Ahmed A. 
Published: February 2020

Objective
The aim of the study was to assess safety and efficacy of 50-mg tramadol in reducing patient-perceived pain during colposcopy.

Material and Methods
We conducted a randomized double-blind placebo-controlled trial in the colposcopy unit of a tertiary referral hospital, Cairo, Egypt, from April 2018 to October 2018. Our primary outcome was pain during colposcopy-guided ectocervical punch biopsy. Our secondary outcomes were pain during speculum insertion, acetic acid application, Lugol iodine application, endocervical curettage (ECC), endocervical brushing, 10-minute postprocedure, and additional analgesia requirement. Pain was assessed using 10-cm visual analog scale.

Results
One hundred fifty women were randomized into 2 groups: tramadol group (n = 75) received oral 50-mg tramadol tablets, and control group (n = 75) received placebo tablets. Both groups showed no significant difference in anticipated pain score (p = .56), pain scores during speculum insertion (p = .70), application of acetic acid (p = .40), and Lugol iodine (p = .79). However, the mean pain scores were significantly lower in tramadol group compared with placebo at ectocervical biopsy (p = .001), ECC (p = .001), endocervical brushing (p = .001), and 10 minutes after colposcopy (p = .001). Need for additional analgesia was significantly lower in tramadol group (p = .03).

Conclusions
Oral tramadol 50 mg significantly reduces pain perception during colposcopy-guided ectocervical biopsy, ECC, endocervical brushing, and 10 minutes after colposcopy with tolerable adverse effects.
Subgaleal Hemorrhage Secondary to Child Physical Abuse in a 4-Year-Old Boy
Authors: Bowens Joseph P. , Liker Kelly 
Published: February 2020

Abstract
Subgaleal hemorrhage is commonly described in the neonatal population but is a rare injury in young children and adolescents. Though infrequently seen, it can follow blunt head trauma or hair pulling. This case report details a 4-year-old African American boy with massive subgaleal hemorrhage and bilateral periorbital swelling and ecchymosis as a result of hair pulling in the setting of child physical abuse. The patient was evaluated in the emergency department for swelling of his scalp several hours after reportedly bumping his head on a chair. He was discharged home after a head computed tomography only confirmed soft tissue hematoma. The following morning, the findings progressed and he returned to the emergency department. He was triaged as a trauma and initially evaluated by the emergency physician, pediatric trauma surgeon, and pediatric neurosurgeon. Head computed tomography scan confirmed diffuse scalp edema without skull fracture or intracranial pathology. The child abuse specialty service was consulted for suspected child physical abuse. Their examination revealed numerous scattered bruises on the trunk and thighs, several of which were patterned. Local police investigation resulted in the patient's grandfather confessing to striking the patient with a belt and picking him up from the ground by his hair, the latter of which is a mechanism consistent with the patient's dramatic scalp and facial findings. The authors encourage consultation by a specialist in child abuse pediatrics for subgaleal hemorrhage and/or raccoon eyes in the presence of minor trauma, as well as thorough head-to-toe skin examination for all children presenting with injuries.
A Framework for Quality Assurance of Pediatric Revisits to the Emergency Department
Authors: Marchese Ronald F. , Taylor April , Voorhis Catherine B. , Wall Jessica , Szydlowski Ellen G. , Shaw Kathy N. 
Published: February 2020

Background
Emergency department return visits significantly impact medical costs and patient flow. A comprehensive approach to understanding these patients is required to identify deficits in care, system level inefficiencies, and improve diagnosis specific management protocols. We aimed to identify factors needed to successfully analyze return visits to explore root causes leading to unplanned returns and inform system-level improvements.

Methods
A multidisciplinary committee collaborated to develop a quality review process for return visits within 72 hours to our pediatric emergency department that were then subsequently admitted to the hospital. The committee developed methodology and a web-based tool for chart review and analysis.

Results
Of 197,076 ED visits (159,164 discharged at initial visit), 5390 (3.4%) patients were discharged and represented to the ED within 72 hours and 1658 (1.0%) of those resulted in admission. Using defined criteria, approximately one third (n = 564) of revisits with admission were identified for chart review. Reason for revisit included natural progression of disease (67.6%), new condition or problem (11.2%), diagnostic error (6.9%), and scheduled or planned readmissions (3.5%). All diagnostic errors had not been previously identified by ED leadership. Of the reviewed cases, most were not preventable (84.0%); however, a number of system-level actions resulted from discussion of the potentially preventable revisits.

Conclusions
Seventy-two-hour ED revisits were efficiently and systematically categorized with determination of root causes and preventability. This process resulted in shared provider-level feedback, identifying trends in revisits, and implementation of system-level actions, therefore, encouraging other institutions to adopt a similar process.
Epidemiological Development of Novel Coronavirus Pneumonia in China and Its Forecast
Authors: Wu Shanshan , Sun Panpan , Li Ruiling , Zhao Liang , Wang Yanli , Jiang Lifang , Wang Haili , Deng Jinbo 
Published: February 2020

ABSTRACTBACKGROUND AND OBJECTIVEThe novel coronavirus (SARS-Cov-2) infected coronavirus disease 2019 (COVID-19) was broken out in Wuhan and Hubei province for more than a month. It severely threats people’s health of thousands in Chin and even other countries. In order to prevent its wide spread, it is necessary to understand the development of the epidemic with precise mathematical language.METHODSThe various data of novel coronavirus pneumonia were collected from the official websites of the National Health Committee of the People’s Republic of China. According to epidemic and administrative division, three groups were divided to analyze the data, Hubei Province (including Wuhan), nationwide without Hubei and Henan Province. With classic SIR models, the fitting epidemiological curves of incidence have made, and basic reproduction number (R0) was also calculated as well. Therefore the disease’s infection intensity, peak time and the epidemiological end time can be deduced.RESULTS(1) Wuhan was the origin place of the epidemic, then it spread to Hubei province quickly. The patients in Hubei had increased rapidly with exponential rise. According to data in Hubei province, the fitting parabolas were made, and some with 51,673 cases. R0 curve shows with S-curve, at early breakout, R0 was as high as 6.27, then it decrease gradually. It is expected to approach to zero in early May; (2) In the group of nationwide without Hubei, the patient cases were much lower than Hubei, but its epidemiological fitting curve also shows a parabola as Hubei. The peak will arrive around February 10 with 9,145 cases. At beginning, R0 was as high as 2.44, then it decreases gradually and approach to zero in the end of March. (3) In Henan Province, the incidence stays very low, the parabolic fitting curve is similar to the nationwide without Hubei. The epidemic is expected to reach the peak on around February 12 and end in early April.CONCLUSIONThe epidemic development in all three groups shows parabolic curves. Their incidences are expected to reach their peaks on February 18 in Hubei, on February 10 in other areas of China. The epidemic will end in early May in Hubei, and in early April in other areas of China. Our study may provide useful knowledge for the government to make prevention and treatment policies.
Demonstration of four entities of appendicitis in China through studying cluster/outbreak
Authors: Guo Yi-Tian , Ye De-qiang , Yang Gui-fang , Liu Guozhen , Cui Xiao-chen , Tan Shi-Yun , Guo Yi 
Published: February 2020

AbstractObjectiveTo differentiate different entities of appendicitis through studying cluster/outbreak, ascertain common setting of cluster/outbreak, and provide the epidemiological evidences of infectious etiology of appendicitis.BackgroundDifferential diagnosis and management for perforated appendicitis and non-perforated appendicitis and the infectious etiology of appendicitis are current hot topics.MethodsField investigation for Tibetan students were carried out and reports published in English and Chinese medical journals were reviewed.ResultsThe literature review included 473 patients in 7 cluster/outbreaks of appendicitis in 6 provinces and autonomous regions. All the clusters/outbreaks occurred in group living units. We found two classic entities of appendicitis with natural history from non-perforated appendicitis to perforated appendicitis and two entities of non-perforated appendicitis. In classic entities, one may represent majority of sporadic patients and the other may represent partial sporadic patients with obvious gastrointestinal manifestation. In entities of non-perforated appendicitis, one was identical to features of sporadic non-perforated appendicitis and the other one is identical to the following Tibetan students and associated with Fusobacterium.The field investigation for 120 Tibetan students with appendicitis showed that the resected appendices exhibited diffuse or focal hemorrhages and infiltration by eosinophils and by lymphocytes. Most patients had normal body temperature, white blood cell count and neutrophil count. This is a new entity of appendicitis.The clusters/outbreaks of appendicitis showed the features of infectious disease in epidemiology. The entity of perforated appendicitis was not found.ConclusionStudying cluster/outbreak is a good method to differentiate different entities of appendicitis and infectious etiology.
Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
Authors: Muto Vincenzo , Koshmanova Ekaterina , Ghaemmaghami Pouya , Jaspar Mathieu , Meyer Christelle , Elansary Mahmoud , Van Egroo Maxime , Chylinski Daphne , Berthomier Christian , Brandewinder Marie , Mouraux Charlotte , Schmidt Christina , Hammad Grégory , Coppieters Wouter , Ahariz Naima , Degueldre Christian , Luxen André , Salmon Eric , Phillips Christophe , Archer Simon N. , Yengo Loic , Byrne Enda , Collette Fabienne , Georges Michel , Dijk Derk-Jan , Maquet Pierre , Visscher Peter M. , Vandewalle Gilles 
Published: February 2020

AbstractStudy ObjectivesSleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset.MethodsWe computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation and extended sleep opportunity, in a carefully selected homogenous sample of healthy 363 young men (22.1 y ± 2.7) devoid of sleep and cognitive disorders.ResultsAD PRS was associated with more slow wave energy, i.e. the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with large slow wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness.ConclusionsThese results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.Statement of SignificanceWe show that the genetic liability for developing for Alzheimer’s disease (AD), as grasped over the entire genome using polygenic risk scores (PRS), is associated with sleep intensity and daytime sleepiness in healthy individuals devoid of sleep disorders and aged < 30 y, i.e. 30 to 60 years before typical onset of AD cognitive symptoms. Sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative. The findings reinforce the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.