bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of doravirine-associated resistance mutations in HIV-1-infected antiretroviral-experienced patients from two large databases in France and Italy
Authors: Soulie Cathia , Santoro Maria Mercedes , Storto Alexandre , Abdi Basma , Charpentier Charlotte , Armenia Daniele , Jary Aude , Forbici Federica , Bertoli Ada , Gennari William , Andreoni Massimo , Mussini Cristina , Antinori Andrea , Perno Carlo Federico , Calvez Vincent , Ceccherini-Silberstein Francesca , Descamps Diane , Marcelin Anne-Genevieve 
Published: December 2019

Abstract

Objectives
Doravirine, a novel NNRTI, selects for specific mutations in vitro, including mutations at reverse transcriptase (RT) positions 106, 108, 188, 227, 230 and 234. The aim of this study was to examine the prevalence of doravirine-associated resistance mutations in HIV-1-infected antiretroviral-experienced patients.

Methods
Doravirine-associated resistance mutations identified in vitro or in vivo were studied in a set of 9199 HIV-1 RT sequences from HIV-1 antiretroviral-experienced patients, including 381 NNRTI-failing patients in France and Italy between 2012 and 2017. The following mutations were considered as resistance mutations: V106A/M, V108I, Y188L, G190S, F227C/L/V, M230I/L, L234I, P236L, K103N + Y181C, K103N + P225H and K103N + L100I.

Results
The frequencies of doravirine-associated resistance mutations (total dataset versus NNRTI-failing patients) were: V106A/M, 0.8% versus 2.6%; V108I, 3.3% versus 9.2%; Y188L, 1.2% versus 2.6%; G190S, 0.3% versus 2.1%; F227C/L/V, 0.5% versus 1.8%; M230I/L, 2.8% versus 0%; L234I, 0.1% versus 0.5%; K103N + Y181C, 3.9% versus 3.9%; K103N + P225H, 2.9% versus 4.7%; and K103N + L100I, 1.7% versus 3.9%, with a significantly higher proportion of these mutations in the NNRTI-failing group (P &lt; 0.05), except for M230I/L and K103N + Y181C. The overall prevalence of sequences with at least one doravirine-associated resistance mutation was 12.2% and 34.9% in the total dataset and NNRTI-failing patients (P &lt; 0.001), respectively. In comparison, the prevalence of the common NNRTI mutations V90I, K101E/P, K103N/S, E138A/G/K/Q/R/S, Y181C/I/V and G190A/E/S/Q were higher (8.9%, 7.9%, 28.6%, 12.6%, 14.2% and 8.9%, respectively).

Conclusions
These results suggest that doravirine resistance in antiretroviral-experienced patients generally and specifically among NNRTI-failing patients is lower than resistance to other NNRTIs currently used, confirming its distinguishing resistance pattern.
Measuring implementation feasibility of clinical decision support alerts for clinical practice recommendations
Authors: Richesson Rachel L , Staes Catherine J , Douthit Brian J , Thoureen Traci , Hatch Daniel J , Kawamoto Kensaku , Del Fiol Guilherme 
Published: December 2019

Abstract

Objective
The study sought to describe key features of clinical concepts and data required to implement clinical practice recommendations as clinical decision support (CDS) tools in electronic health record systems and to identify recommendation features that predict feasibility of implementation.

Materials and Methods
Using semistructured interviews, CDS implementers and clinician subject matter experts from 7 academic medical centers rated the feasibility of implementing 10 American College of Emergency Physicians Choosing Wisely Recommendations as electronic health record–embedded CDS and estimated the need for additional data collection. Ratings were combined with objective features of the guidelines to develop a predictive model for technical implementation feasibility.

Results
A linear mixed model showed that the need for new data collection was predictive of lower implementation feasibility. The number of clinical concepts in each recommendation, need for historical data, and ambiguity of clinical concepts were not predictive of implementation feasibility.

Conclusions
The availability of data and need for additional data collection are essential to assess the feasibility of CDS implementation. Authors of practice recommendations and guidelines can enable organizations to more rapidly assess data availability and feasibility of implementation by including operational definitions for required data.
‘An indefatigable intermediary’
Authors: Rowlands Eliot W 
Published: December 2019

Abstract
O n 4 June 1925, Harold Woodbury Parsons was appointed European Representative to the Cleveland Museum of Art; for the remainder of the decade he distinguished himself in scouting for and acquiring masterworks of European art for the essentially brand new institution. His long-time contacts in Rome, to begin with, led him to a famous Byzantine ivory (formerly in the collection of Count Grigorij Stroganoff). This he bought for the museum in November 1925, winning enthusiastic praise from Paul J. Sachs, a key figure in American museological circles. Similarly, he acquired soon afterwards El Greco’s Holy Family with St Mary Magdalen, despite intense competition. Parsons was ideally placed in the sale of Filippino Lippi’s Holy Family tondo as a sometime agent for the antiquities collector Edward Perry Warren (recently deceased). Parsons’s correspondence and unpublished notices in the Duveen Brothers records document the off-again, on-again dealing for what is now one of the pre-eminent Italian Renaissance paintings in America, acquired in August 1929.
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity
Authors: Iacono Diego , Lee Patricia , Edlow Brian L , Gray Nichelle , Fischl Bruce , Kenney Kimbra , Lew Henry L , Lozanoff Scott , Liacouras Peter , Lichtenberger John , Dams-O’Connor Kristen , Cifu David , Hinds Sidney R , Perl Daniel P 
Published: December 2019

Abstract
The neuropathology associated with cognitive decline in military personnel exposed to traumatic brain injury (TBI) and chronic stress is incompletely understood. Few studies have examined clinicopathologic correlations between phosphorylated-tau neurofibrillary tangles, β-amyloid neuritic plaques, neuroinflammation, or white matter (WM) lesions, and neuropsychiatric disorders in veterans. We describe clinicopathologic findings in 4 military veterans with early-onset dementia (EOD) who had varying histories of blunt- and blast-TBI, cognitive decline, behavioral abnormalities, post-traumatic stress disorder, suicidal ideation, and suicide. We found that pathologic lesions in these military-EOD cases could not be categorized as classic Alzheimer’s disease (AD), chronic traumatic encephalopathy, traumatic axonal injury, or other well-characterized clinicopathologic entities. Rather, we observed a mixture of polypathology with unusual patterns compared with pathologies found in AD or other dementias. Also, ultrahigh resolution ex vivo MRI in 2 of these 4 brains revealed unusual patterns of periventricular WM injury. These findings suggest that military-EOD cases are associated with atypical combinations of brain lesions and distribution rarely seen in nonmilitary populations. Future prospective studies that acquire neuropsychiatric data before and after deployments, as well as genetic and environmental exposure data, are needed to further elucidate clinicopathologic correlations in military-EOD.
Endoscopic endonasal removal of a large fibrous dysplasia of the paranasal sinuses and skull base
Authors: AlMomen Ali A , Molani Fadel M , AlFaleh Moath A , AlMohisin Ahmed K 
Published: December 2019

Abstract
Fibrous dysplasia is a rare condition. We present a case of a 34-years-old man presented with left-sided facial pain, headache and nasal obstruction for a long duration. CT scan of the sinuses showed a mass occupying the left ethmoidal region abutting the orbit and skull base obstructing the left frontal sinus. The patient was treated successfully by image-guided endoscopic endonasal removal of the tumor with no recurrence after 3 years of follow-up. This report aims to show the usefulness of endoscopic endonasal removal of a large fibrous dysplasia of paranasal sinuses and skull base.
βVPE is involved in tapetal degradation and pollen development by activating proprotease maturation in Arabidopsis thaliana
Authors: Cheng Ziyi , Guo Xiaorui , Zhang Jiaxue , Liu Yadi , Wang Bing , Li Hui , Lu Hai 
Published: December 2019

Abstract
Vacuolar processing enzyme (VPE) is responsible for the maturation and activation of vacuolar proteins in plants. We found that βVPE was involved in tapetal degradation and pollen development by transforming proproteases into mature protease in Arabidopsis thaliana. βVPE was expressed specifically in the tapetum from stages 5 to 8 of anther development. The βVPE protein first appeared as a proenzyme and was transformed into the mature enzyme before stages 7–8. The recombinant βVPE protein self-cleaved and transformed into a 27 kDa mature protein at pH 5.2. The mature βVPE protein could induce the maturation of CEP1 in vitro. βvpe mutants exhibited delayed vacuolar degradation and decreased pollen fertility. The maturation of CEP1, RD19A, and RD19C was seriously inhibited in βvpe mutants. Our results indicate that βVPE is a crucial processing enzyme that directly participates in the maturation of cysteine proteases before vacuolar degradation, and is indirectly involved in pollen development and tapetal cell degradation.
Thioredoxin targets are regulated in heterocysts of cyanobacterium Anabaena sp. PCC 7120 in a light-independent manner
Authors: Mihara Shoko , Sugiura Kazunori , Yoshida Keisuke , Hisabori Toru 
Published: December 2019

Abstract
In the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120, glucose 6-phosphate dehydrogenase (G6PDH) plays an important role in producing the power for reducing nitrogenase under light conditions. Our previous study showed that thioredoxin suppresses G6PDH by reducing its activator protein OpcA, implying that G6PDH is inactivated under light conditions because thioredoxins are reduced by the photosynthetic electron transport system in cyanobacteria. To address how Anabaena sp. PCC 7120 maintains G6PDH activity even under light conditions when nitrogen fixation occurs, we investigated the redox regulation system in vegetative cells and specific nitrogen-fixing cells named heterocysts, individually. We found that thioredoxin target proteins were more oxidized in heterocysts than in vegetative cells under light conditions. Alterations in the redox regulation mechanism of heterocysts may affect the redox states of thioredoxin target proteins, including OpcA, so that G6PDH is activated in heterocysts even under light conditions.
Red or white? Color in Chinese folksongs
Authors: Zhang Xiaojin , Liu Haitao 
Published: December 2019

AbstractColor preference in Chinese folksongs is examined from the perspectives of themes, ethnicity, and geographical environment. The results yield that self-organization property of language system plays the role in color use and color preference varies with theme, ethnicity, and geographical environment. Specifically, the color of white is preferred by twenty-three ethnic minorities and the color of red is much more popular among the Han. Only in love songs, the preference for white and red exhibits an approximate north and south dimension. The study shows that digital approaches related to colors in folklore are an effective and promising tool to explore human’s response to colors.
Towards the development of a grammar checker and its utilization in the teaching of Modern Greek as mother tongue
Authors: Gakis Panagiotis , Kokkinos Theodoros , Tsalidis Christos 
Published: December 2019

Abstract
The goal of the current study is the exploration of the standardization of grammatical errors through templates, a process that ultimately led to the development of a Grammar Checker for Modern Greek, an electronic tool for the automatic recognition and correction of grammatical errors. Moreover, the study investigates the utilization of such a tool in a classroom setting and its contribution to the teaching of mother tongue. The participants of the study were secondary school students and main results showed that errors they made in text production activities could be categorized as errors of mechanics, grammar, and usage through certain templates, which then lead to the development of a Grammar Checker for Modern Greek. Moreover, we also found other errors that could not be analysed and categorized using the theory of taxonomy of errors by Ho, i.e. style: forms—learned forms and semantic. Additionally, the participants highlighted that the specific tool has advantages for the teaching of mother tongue. Implications for the methodology of Grammar Checkers’ development and their use in the teaching of mother tongue, generally, are discussed.
Tomographic measurement of the intergalactic gas pressure through galaxy–tSZ cross-correlations
Authors: Koukoufilippas Nick , Alonso David , Bilicki Maciej , Peacock John A 
Published: December 2019

ABSTRACT
We cross-correlate maps of the thermal Sunyaev–Zeldovich (tSZ) Compton-y parameter published by Planck with the projected distribution of galaxies in a set of low-redshift tomographic bins. We use the nearly full-sky 2MASS Photometric Redshift and WISE × SuperCOSMOS public catalogues, covering the redshift range z ≲ 0.4. Our measurements allow us to place constraints on the redshift dependence of the mass–observable relation for tSZ cluster count analyses in terms of the so-called hydrostatic mass bias parameter $1-b_{\scriptscriptstyle \rm H}$. These results can also be interpreted as measurements of the bias-weighted average gas pressure 〈bPe〉 as a function of redshift, a quantity that can be related to the thermodynamics of gas inside haloes and used to constrain energy injection processes. We measure $1-b_{\scriptscriptstyle \rm H}$ with $\sim \!13{{\ \rm per\ cent}}$ precision in six equispaced redshift bins, and find no evidence for a redshift-dependent mass bias parameter, in agreement with previous analyses. Our mean value of $1-b_{\scriptscriptstyle \rm H}= 0.59\pm 0.03$ is also in good agreement with the one estimated by the joint analysis of Planck cluster counts and cosmic microwave background anisotropies. Our measurements of 〈bPe〉, at the level of $\sim \!10{{\ \rm per\ cent}}$ in each bin, are the most stringent constraints on the redshift dependence of this parameter to date, and agree well both with previous measurements and with theoretical expectations from shock-heating models.
The lifecycle of molecular clouds in nearby star-forming disc galaxies
Authors: Chevance Mélanie , Kruijssen J M Diederik , Hygate Alexander P S , Schruba Andreas , Longmore Steven N , Groves Brent , Henshaw Jonathan D , Herrera Cinthya N , Hughes Annie , Jeffreson Sarah M R , Lang Philipp , Leroy Adam K , Meidt Sharon E , Pety Jérôme , Razza Alessandro , Rosolowsky Erik , Schinnerer Eva , Bigiel Frank , Blanc Guillermo A , Emsellem Eric , Faesi Christopher M , Glover Simon C O , Haydon Daniel T , Ho I-Ting , Kreckel Kathryn , Lee Janice C , Liu Daizhong , Querejeta Miguel , Saito Toshiki , Sun Jiayi , Usero Antonio , Utomo Dyas 
Published: December 2019

ABSTRACT
It remains a major challenge to derive a theory of cloud-scale ($\lesssim100$ pc) star formation and feedback, describing how galaxies convert gas into stars as a function of the galactic environment. Progress has been hampered by a lack of robust empirical constraints on the giant molecular cloud (GMC) lifecycle. We address this problem by systematically applying a new statistical method for measuring the evolutionary timeline of the GMC lifecycle, star formation, and feedback to a sample of nine nearby disc galaxies, observed as part of the PHANGS-ALMA survey. We measure the spatially resolved (∼100 pc) CO-to-H α flux ratio and find a universal de-correlation between molecular gas and young stars on GMC scales, allowing us to quantify the underlying evolutionary timeline. GMC lifetimes are short, typically $10\!-\!30\,{\rm Myr}$, and exhibit environmental variation, between and within galaxies. At kpc-scale molecular gas surface densities $\Sigma _{\rm H_2}\ge 8\,\rm {M_\odot}\,{{\rm pc}}^{-2}$, the GMC lifetime correlates with time-scales for galactic dynamical processes, whereas at $\Sigma _{\rm H_2}\le 8\,\rm {M_\odot}\,{{\rm pc}}^{-2}$ GMCs decouple from galactic dynamics and live for an internal dynamical time-scale. After a long inert phase without massive star formation traced by H α (75–90 per cent of the cloud lifetime), GMCs disperse within just $1\!-\!5\,{\rm Myr}$ once massive stars emerge. The dispersal is most likely due to early stellar feedback, causing GMCs to achieve integrated star formation efficiencies of 4–10 per cent. These results show that galactic star formation is governed by cloud-scale, environmentally dependent, dynamical processes driving rapid evolutionary cycling. GMCs and H ii regions are the fundamental units undergoing these lifecycles, with mean separations of $100\!-\!300\,{{\rm pc}}$ in star-forming discs. Future work should characterize the multiscale physics and mass flows driving these lifecycles.
Galaxy And Mass Assembly (GAMA): Defining passive galaxy samples and searching for the UV upturn
Authors: Phillipps S , Ali S S , Bremer M N , De Propris R , Sansom A E , Cluver M E , Alpaslan M , Brough S , Brown M J I , Davies L J M , Driver S P , Grootes M W , Holwerda B W , Hopkins A M , James P A , Pimbblet K , Robotham A S G , Taylor E N , Wang L 
Published: December 2019

ABSTRACT
We use data from the GAMA and GALEX surveys to demonstrate that the UV upturn, an unexpected excess of ultraviolet flux from a hot stellar component, seen in the spectra of many early-type galaxies, arises from processes internal to individual galaxies with no measurable influence from the galaxies’ larger environment. We first define a clean sample of passive galaxies without a significant contribution to their UV flux from low-level star formation. We confirm that galaxies with the optical colours of red sequence galaxies often have signs of residual star formation, which, without other information, would prevent a convincing demonstration of the presence of UV upturns. However, by including (NUV−u) and WISE (W2–W3) colours, and FUV data where it exists, we can convincingly constrain samples to be composed of non-star-forming objects. Using such a sample, we examine GALEX photometry of low-redshift GAMA galaxies in a range of low-density environments, from groups to the general field, searching for UV upturns. We find a wide range of (NUV−r) colours, entirely consistent with the range seen – and attributed to the UV upturn – in low-redshift red sequence cluster galaxies. The range of colours is independent of group multiplicity or velocity dispersion, with isolated passive galaxies just as likely to have blue UV-to-optical colours, implying significant upturn components, as those in richer groups and in the previous data on clusters. This is supported by equivalent results for (FUV−r) colours which are clear indicators of upturn components.
Probing the early phases of high-mass star formation with 6.7 GHz methanol masers
Authors: Paulson Sonu Tabitha , Pandian Jagadheep D 
Published: December 2019

ABSTRACT
Methanol masers at 6.7 GHz are the brightest of class II methanol masers and have been found exclusively towards massive star-forming regions. These masers can thus be used as a unique tool to probe the early phases of massive star formation. We present here a study of the spectral energy distributions of 320 6.7 GHz methanol masers chosen from the Methanol Multibeam catalogue, which fall in the Hi-GAL range (|l| ≤ 60°, |b| ≤ 1°). The spectral energy distributions are constructed from 870 to 70 µm using data from the ATLASGAL and Hi-GAL surveys. The emission from cold dust is modelled by a single grey body component fit. We estimate the clump properties such as mass, far-infrared luminosity, and column density using the best-fitting parameters of the SED fits. Considering the Kauffman criteria for massive star formation, we find that all but a few maser hosts have the potential to harbour at least one high-mass star. The physical properties of the methanol maser hosts are also discussed. The evolutionary stages of 6.7 GHz maser sources, explored using the mass luminosity diagram, suggest that they are predominantly associated with high-mass stars with the majority being in the accretion phase. However, we observe a small number of sources that could possibly be related to intermediate- or low-mass stars.
Quality controls induced by aberrant translation
Authors: Inada Toshifumi 
Published: December 2019

Abstract
During protein synthesis, translating ribosomes encounter many challenges imposed by various types of defective mRNAs that can lead to reduced cellular fitness and, in some cases, even threaten cell viability. Aberrant translation leads to activation of one of several quality control pathways depending on the nature of the problem. These pathways promote the degradation of the problematic mRNA as well as the incomplete translation product, the nascent polypeptide chain. Many of these quality control systems feature critical roles for specialized regulatory factors that work in concert with conventional factors. This review focuses on the mechanisms used by these quality control pathways to recognize aberrant ribosome stalling and discusses the conservation of these systems.
Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter
Authors: Wang Zi-Fu , Li Ming-Hao , Chu I-Te , Winnerdy Fernaldo R , Phan Anh T , Chang Ta-Chau 
Published: December 2019

Abstract
Time-resolved imino proton nuclear magnetic resonance spectra of the WT22m sequence d(GGGCCACCGGGCAGTGGGCGGG), derived from the WNT1 promoter region, revealed an intermediate G-quadruplex G4(I) structure during K+-induced conformational transition from an initial hairpin structure to the final G4(II) structure. Moreover, a single-base C-to-T mutation at either position C4 or C7 of WT22m could lock the intermediate G4(I) structure without further conformational change to the final G4(II) structure. Surprisingly, we found that the intermediate G4(I) structure is an atypical G4 structure, which differs from a typical hybrid G4 structure of the final G4(II) structure. Further studies of modified cytosine analogues associated with epigenetic regulation indicated that slight modification on a cytosine could modulate G4 structure. A simplified four-state transition model was introduced to describe such conformational transition and disclose the possible mechanism for G4 structural selection caused by cytosine modification.