bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of cytoreductive partial nephrectomy in elderly patients with metastatic renal cell carcinoma：a systematic review
Authors: Zhuang Wei , Chen Jiabi , Li Yining , Su Xiaoping 
Published: November 2019

Abstract
Background To explore the survival value of cytoreductive partial nephrectomy (cPN) in elderly metastatic renal cell carcinoma (EmRCC).Methods RCC patients aged ≥65 years from 2010 to 2015 in The Surveillance, Epidemiology and End Result database (SEER) were analyzed using Kaplan-Meier (K-M) method and multivariate COX analysis. Propensity score matching (PSM) was performed to balance effects of confounding factors such as general features and pathological features. We were committed to study the long-term survival advantages of cPN patients, explore the appropriate population of cPN, and try to establish a Nomogram model to predict individual survival.Results In EmRCC patients, especially in male patients with tumors size ≦7cm, N0 stage, or isolated metastases, cPN brought a better survival than cytoreductive radical nephrectomy (cRN). Tumor size and N stage were independent risk factors affecting the survival of cPN patients, cPN in patients with tumor size >7cm or N1 stage may present a higher risk of death.Conclusions The implementation of cPN in EmRCC patients who meet specific clinical characteristics like tumors size ≦7cm, N0 stage, or isolated metastases seems to help improve the tumor outcomes.
Clinical Characteristics of Behcet’s Disease in 453 Egyptian Patients Suffering from Uveitis with Gender Comparison
Authors: Elshahaly Mohsen , Latif Iman Abd El , Bassiouni Hassan 
Published: November 2019

Objective:
To describe the clinical features in patients with Behcet’s disease suffering
from uveitis in Egypt and to compare the findings between both genders.

Methods:
453 subjects fulfilling the 1990 Classification criteria for Behcet’s disease and with uveitis
in at least one eye. Follow-up was done for two years.

Results:
Oral ulcers and recurrent iridocyclitis occurred in all patients during their disease course.
The prevalence of genital ulcers, erythema nodosum, and joint involvement were similar between
both sexes. The prevalence of all ocular findings was higher in females except for retinal hemorrhages.
The incidence of secondary cataract and glaucoma in addition to vitreous opacities was
similar between both sexes. 13.7% of patients had GIT manifestations. Vascular complications
were present in 128 (28.2%) patients.

:
Aseptic meningitis and hemiplegia were only found in males. 1.7% of males and 3.2% of females
suffered from brainstem involvement. Superior sagittal sinus thrombosis was present in females
only. Acute phase reactants (ESR & CRP) were significantly higher in females (p<0.0001).

Conclusion:
The disease characteristics of BD patients with uveitis in Egypt might be different
from the BD patients of other countries. The markers of inflammation were higher in females compared
to males. The ocular manifestations were more common in females.
Recurrent Vulvovaginal Candidiasis: The Causative Agents, Clinical Signs and Susceptibility to Fluconazole in Gonabad City, Northeast Iran
Authors: Minooeianhaghighi Mohammad Hassan , Sehatpour Marziyeh , Zarrinfar Hossein , Sen Tanuka 
Published: November 2019

Background:Recurrent vulvovaginal candidiasis (RVVC) is the second most common cause of genital tract infection in females. Excessive use of fluconazole and other azoles is likely to cause the emergence of the resistant species of Candida.Objective :The purpose of this research was to identify Candida isolates from RVVC and the antifungal effect of fluconazole against them.Methods :In this study, 152 patients with vulvovaginal candidiasis were evaluated for the RVVC form. The Candida isolates were purified using CHROMagar Candida and identified based on the nuclear ribosomal internal transcribed spacer (ITS1-ITS2 rDNA) sequence analysis by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The antifungal susceptibility of C. albicans isolates against fluconazole was determined according to document M27-A3.Results:Out of 152 patients, 20 cases (13.2%) were identified as recurrent form. The frequencies of the Candida species among the patients with RVVC were C. albicans (n = 16, 80%), C. parapsilosis (n = 3, 15%) and C. tropicalis (n = 1, 5%). The most common clinical sign was vaginal discharge (60%). The mean minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of fluconazole against Candida isolates were 32 µg/mL and 64 µg/mL, respectively.Conclusion:C. albicans was the dominant cause of RVVC. The Candida isolates showed relatively high resistance to fluconazole in vitro. Vaginal discharge was the most common clinical sign among patients with RVVC.
Contribution of Magnetic Resonance Imaging in Determining Lumpectomy Cavity in Breast Radiotherapy
Authors: Demircioglu Ozlem , Tepetam Huseyin , Eren Ayfer Ay , Ozgen Zerrin , Demircioglu Fatih , Aribal Erkin 
Published: November 2019

Background:
Accurate localization of the lumpectomy cavity is important for breast
cancer radiotherapy after breast-conserving surgery (BCS), but the LC localization based on CT is
often difficult to delineate accurately. The study aimed to compare CT-defined LC planning to
MRI-defined findings in the supine position for higher soft-tissue resolution of MRI.

Methods:
Fifty-nine breast cancer patients underwent radiotherapy CT planning in supine position
followed by MR imaging on the same day. LC was contoured by the radiologist and radiation oncologist
together by CT and MRI separately. T2 weighted MR images and tomography findings
were combined and the LC volume, mean diameter and the longest axis length were measured after
contouring. Subsequently, patients were divided into two groups according to seroma in LC
and the above-mentioned parameters were compared.

Results:
We did not find any statistically significant difference in the LC volume, mean diameter
and length at the longest axis between CT and MRI but based on the presence or absence of seroma,
statistically significant differences were found in the LC volumes and the length at the
longest axis of LC volumes.

Conclusion:
We believe that the supine MRI in the same position with CT will be more effective
for radiotherapy planning, particularly in patients without a seroma in the surgical cavity.
Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A
Authors: Soori Shahrzad , Dadashizadeh Ghazaleh , Dorgalaleh Akbar , Tabibian Shadi , Keramati Mohammad R. , Alizadeh Shaban , Hosseini Maryam S. , Zaker Farhad , Shams Mahmood 
Published: November 2019

Background:About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA.Methods:We divided 39 patients with severe HA in two groups of case (n: 19) and control (n: 20). Genotyping was performed by multiplex amplification tetra arms refractory mutation systempolymerase chain reaction (ARMS-PCR) and PCR-restriction fragment-length polymorphism (PCR-RFLP).Results:TNFα rs1800629 G>A polymorphism decreased the risk of inhibitor development in codominant and dominant inheritance pattern. Moreover, TNFα rs1800629 A allele, decrease the risk of inhibitor formation, while IL10 rs1800896 A>G, FV rs6025 G>A, and FII rs1799963 G>A polymorphisms were not associated with risk of inhibitor development.Conclusion:It seems that TNFα rs1800629 G>A polymorphism decreased the risk of inhibitor formation in Iranian patients with HA.
Mucoadhesive Buccal Patch Role in Emesis: Tweaked up by the Pivotal Permeation Enhancer: Sodium Lauryl Sulphate
Authors: Nishchaya Kumar , Kushwaha Swatantra K.S. , Aziz Namra , Bansode Himanshu , Tiwari Jagriti , Kumar Abhitendra 
Published: November 2019

Background:
It has been observed that several diseases either acute or chronic have a specific
symptom that is emesis. Emesis leads to depletion and removal of several salts and biological essentials
required in the body. Domperidone is a D2 receptor antagonist, which triggers the chemoreceptor
trigger zone (CTZ) and hence used in the management of nausea and vomiting.

Objective:
The objective of this project was to formulate a buccal patch of domperidone with the use
of several polymers with a permeation enhancer. Since the oral bioavailability of domperidone is low
due to gastric degradation, hence a buccal patch was prepared to determine its bioavailability. The
purpose of this study was to formulate a buccal patch for better bioavailability and observe the effect
of permeation enhancer with polymers.

Method:
The mucoadhesive buccal patch was prepared using the solvent cast method. The characterization
studies were done along with the drug content and compatibility studies through FTIR.

Results:
It was observed that the polymers; sodium carboxy methyl cellulose (SCMC) & polyvinyl
alcohol(PVA) without sodium lauryl sulphate (SLS) had low drug release, which was around 68% and
72%, respectively whereas polymers with SLS had markedly increased drug release, which was
around 89% and 91%, respectively.

Conclusion:
In order to obtain the maximum therapeutic efficacy of domperidone, buccal patches are
considered much more beneficial than oral dosage form. Permeation enhancer also helps to synergize
the effect of polymers which helps in better drug release and ultimately leads to better bioavailability.
A Novel Fault-location Method for HVDC Transmission Lines Based on Concentric Relaxation Principle and Wavelet Packet
Authors: Li Congshan , He Ping , Wang Feng , Yang Cunxiang , Tao Yukun , Ji Yuqi 
Published: November 2019

Background:
A novel fault location method of HVDC transmission line based on a concentric
relaxation principle is proposed in this paper.

Methods:
Due to the different position of fault, the instantaneous energy measured from rectifier
and inverter are different, and the ratio k between them is the relationship to the fault location d.
Through the analysis of amplitude-frequency characteristics, we found that the wave attenuation
characteristic of low frequency in the traveling wave is stable, and the amplitude of energy is larger,
so we get the instantaneous energy ratio by using the low-frequency data. By using the method of
wavelet packet decomposition, the voltage traveling wave signal was decomposed.

Results:
Finally, calculate the value k. By using the data fitting, the relative function of k and d can
be got, that is the fault location function.

Conclusion:
After an exhaustive evaluation process considering different fault locations, fault resistances,
and noise on the unipolar DC transmission system, four-machine two-area AC/DC parallel
system, and an actual complex grid, the method presented here showed a very accurate and robust
behavior.
The effect of the field application upon the attitudes of the applying students of Garmian university towards the teaching career
Authors: Saeed Shwan Faraj 
Published: November 2019

This research aimed to identify the attitudes of students of the Faculty of Education after application , the University of Garmiyan, towards the teaching profession. The sample of the study consisted of (166) students from the fourth stage students (summer applied students) in the Faculty of Education. To achieve the objectives of the study, the researcher used a measure of the direction towards the teaching profession that consisted of (31) paragraphs and verified the reliability and stability of the tool, and the study reached the following results:

Positive attitudes towards the teaching profession of the summer applied students as a result of field application in schools and expressed their answers that the field application will change their personality to the better levels.
There are statistically significant differences between the average of the student's scores to measure the trend towards the teaching profession between the chemistry and mathematics departments and for the benefit of the chemistry department as well. At this point, there were no significant differences among the other departments.

The researcher has come up with a number of suggestions and recommendations under the results of the research, which contribute to the improvement of various aspects of preparation for the employment of this professional teaching.
Pelacakan eskpresi protein pada testis mencit (Mus musculus) setelah paparan esktrak etanol daun mimba (Azadirachta indica)
Authors: Sitasiwi Agung Janika , Isdadiyanto Sri , Mardiati Siti Muflichatun 
Published: November 2019

Abstract Azadirachta indica (Neem) has been shown to affect the fertility of mice by interfering with the synthesis of testosterone in mice. The aim of this study was to detect the testes protein expression of mice after exposure to the ethanolic Neem leaf extract. The laboratory animals of this study were 20 male Swiss Webster mice with three months in age and body weight ranging from 27.5 grams. The mice were divided into two treatment groups, namely K (control group, exposed with distilled water) and P (treatment group, exposed to etahnolic Neem leaf extract with 14 mg/animal /day). The treated were given for 21 days and the testicular protein was carried out on the 22nd day. The variables observed were testes weight, concentration and expression of proteins isolated from the testes. The protein concentration is determined by a spectrophotometer at a wavelength of 450nm. The protein expression was observed and determined based on the results of protein electrophoresis (SDS-PAGE). The results showed that protein expression in the treatment group has a lower concentration compared to the control group. Those results was confirmed by thinner bands in SDS-PAGE result. Those proteins thought to be a fertility determinant in mammals. Keywords : anti-fertility; Neem; protein expression Abstrak Azadirachta indica (Mimba) telah terbukti mempengaruhi fertilitas mencit dengan cara mengganggu sintesis hormon testoteron pada mencit. Penelitian ini bertujuan untuk melacak ekspresi protein pada testis mencit setelah paparan ekstrak etanol daun Mimba. Hewan uji penelitian ini adalah 20 ekor mencit Swiss Webster jantan dengan umur tiga bulan dan bobot badan berkisar 27.5 gram. Hewan uji dibagi menjadi 2 kelompok perlakuan, yaitu K (kelompok kontrol, dipapar akuades) dan P (kelompok perlakuan, dipapar dengan ekstrak etanol daun Mimba dengan dosis 14 mg/ekor/hari). Pemberian bahan uji dilakukan secara oral selama 21 hari. Variabel yang diamati adalah bobot testes, konsentrasi serta eskpresi protein yang diisolasi dari testis. Isolasi protein testis dilakukan pada hari ke-22. Konsentrasi protein ditentukan dengan spectrofotometer pada panjang gelombang 450nm. Ekspresi protein diamati dan ditentukan berdasar hasil elektroforesa protein. Hasil penelitian menunjukkan bahwa ekspresi protein pada kelompok perlakuan menunjukkan konsentrasi yang lebih rendah dengan pita yang lebih tipis jika dibandingkan dengan kelompok kontrol. Kesimpulan penelitian ini adalah paparan ekstrak etanol daun Nimba menyebabkan gangguan ekspresi protein yang diduga berperan dalam menentukan fertilitas mamalia. Kata kunci : Mimba; anti-fertilitas; eskpresi protein;
Fibrillary Glomerulonephritis
Authors: Andeen Nicole K. , Troxell Megan L. , Riazy Maziar , Avasare Rupali S. , Lapasia Jessica , Jefferson J. Ashley , Akilesh Shreeram , Najafian Behzad , Nicosia Roberto F. , Alpers Charles E. , Smith Kelly D. 
Published: November 2019

Background and objectives
Fibrillary GN has been defined as an immune complex-mediated GN with amyloid-like fibrils larger than amyloid which are IgG positive and Congo red negative. With discovery of DNAJB9 as a highly sensitive and specific marker for fibrillary GN, the specificity of the morphologic criteria for establishing the diagnosis of fibrillary GN has come into question.

Design, setting, participants, & measurements
We sought to (1) determine anatomic characteristics that best define fibrillary GN and (2) identify clinical and pathologic features that predict outcomes.

Results
We retrospectively reviewed kidney biopsies from patients diagnosed with fibrillary GN or suspected fibrillary GN between 1997 and 2017 (n=266, 65% female, median age 61). Approximately 11% of kidney biopsies had one or more unusual feature including monotypic deposits, Congo red positivity, or unusual fibril diameter. Fibrillary GN as a possible monoclonal gammopathy of renal significance represented <1% of cases. Immunostaining for DNAJB9 confirmed fibrillary GN in 100% of cases diagnosed as fibrillary GN and 79% of atypical cases diagnosed as possible fibrillary GN. At a median time of 24 months (interquartile range, 8–46 months) after biopsy (n=100), 53% of patients reached the combined primary outcome of ESKD or death, 18% had CKD, and 18% had partial remission. On multivariable analysis, male sex (adjusted hazard ratio [aHR], 3.82; 95% confidence interval [95% CI], 1.97 to 7.37) and eGFR were the most significant predictors of primary outcome (aHR of 8.02 if eGFR <30 ml/min per 1.73 m2 [95% CI, 1.85 to 34.75]; aHR of 6.44 if eGFR 30 to <45 ml/min per 1.73 m2 [95% CI, 1.38 to 29.99]). Immunosuppressive therapy with rituximab was significantly associated with stabilization of disease progression.

Conclusions
Detection of DNAJB9 is a useful diagnostic tool for diagnosing atypical forms of fibrillary GN. The outcomes for fibrillary GN are poor and progression to ESKD is influenced predominantly by the degree of kidney insufficiency at the time of diagnosis and male sex. Rituximab may help preserve kidney function for select patients with fibrillary GN.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_11_04_CJN03870319.mp3
EKSISTENSI PEMERINTAHAN DESA DITINJAU DARI PERSPEKTIF ASAS SUBSIDIARITAS DALAM UNDANG-UNDANG NOMOR 6 TAHUN 2014 TENTANG DESA
Authors: Hariri Achmad 
Published: November 2019

The existence of the Village Government in the perspective of Law Number 6 of 2014 concerning Villages is increasingly clear, it’s because the village is given the authority to manage and regulate its own household as known as the subsidiarity principle, while independence in managing governance in regional government is known as the principle of decentralization. This authority is given to realize the vision of the life of a prosperous and independent village government. But in the implementing regulations contrary to the concepts and principles of the establishment of the Village Law, there are several norms explicitly that village authority is still intervened by the government Supra Desa (Regional Government). The purpose of this study is to analyze the existence of village government. The results of this study recommend that there is a need for synchronization and harmonization between the regulations governing village authority, namely Law number. 6 of 2014 concerning Villages, Government Regulation Number 43 of 2014 concerning Implementation Regulations of Law Number 6 Year 2014 concerning Villages, and Government Regulation Number 60 of 2014 concerning Village Funds sourced from the State Budget.
Extrato de dioclea grandiflora (olho de boi) no processo de cicatrização
Authors: Xavier Gabriela Oliveira , Silva Amanda , Bordino Bruno , Sabino Rodrigo , Oliveira Carlos Rocha , Antunes Valeria Maria de Souza 
Published: November 2019

O olho de boi (Dioclea grandiflora) é uma planta encontrada no cerrado e na caatinga do nordeste brasileiro, da família Fabacea. Grande parte da população de cidades nordestinas, principalmente famílias que tem mais acesso ao cerrado, tem utilizado as raízes e principalmente as sementes desta planta. O objetivo do presente trabalho foi aprofundar e verificar as informações passadas pela população e o que se tem hoje na literatura. Nessa perspectiva, foi necessário avaliar a atividade cicatrizante e o doseamento do teor de colágeno do extrato bruto obtido das cascas das sementes de “olho de boi” (Dioclea grandiflora) em fibroblastos humanos de recém-nascido do sexo masculino. A proliferação das células ocorreu após o tratamento com diferentes concentrações de extrato hidroalcoólico por 24 horas. O método desenvolvido teve como base todos os experimentos passarem pelo teste de viabilidade celular aplicando o corante azul de tripano e análise e interpretação em câmara hemocitométrica por microscopia, para a verificação da atividade cicatrizante, antioxidante e a presença de metabólitos secundários na semente. Foi um método preciso e de fácil execução. Além disso, é importante mostrar o quanto a biodiversidade brasileira traz de benefícios e avanços para pesquisas no setor de fitoterapia se realizados com ética e seriedade.
Avaliação ecotoxicológica de efluentes oriundos da produção tradicional de farinha de mandioca
Authors: Carvalho Emilli Furtado 
Published: November 2019

O objetivo deste artigo foi abordar o aspecto teórico e experimental que norteia a prática da produção de farinha de mandioca, bem como apresentar o estudo da ecotoxicidade relacionada aos efluentes brutos durante o processo de fabricação da farinha. A parte experimental foi desenvolvida em uma análise de ecotoxicidade e um ensaio de alelopatia, que determina determinou potencial tóxico sobre microcrustáceos do qual apresentou resultado bastante significativo quanto aos efeitos na qualidade dos ambientes aquáticos bem como efeito alelopático em baixa concentração dos efluentes brutos da prática da produção tradicional de farinha de mandioca. O artigo permitiu apresentar práticas naturais, como adubo, utilizando este efluente traduzindo em um resultado semelhante ao adubo utilizado com substâncias químicas.
Palavras-chave: Ecotoxicidade, efluente, tóxico.
Sobre a fala dialogal: convergências e divergências entre Jakubinskij, Bakhtin e Volochinov
Authors: Da Cunha Dóris De Arruda C. 
Published: November 2019

Este trabalho se propõe a discutir as ideias de Lev Jakubinskij em Sobre a fala dialogal (edição russa, 1923, tradução brasileira, 2015), as convergências com o pensamento de Bakhtin e Volochinov, bem como as divergências. Os estudos sobre o diálogo não têm uma origem teórica única, mas aparecem ligados aos problemas da prática linguística e cultural russas (ROMASHKO, 2000: 84). Uma parte importante dos trabalhos foi dedicada à dialetologia, ou seja, à fala dialetal, concebida como uma fala dialogal. No entanto, segundo Volochinov, (1992: 147), só existia, em 1929, uma obra, Sobre a fala dialogal, consagrada ao problema do diálogo na linguística russa. Alguns estudiosos de Jakubinskij consideram que esse ensaio serviu de referência para Volochinov e Bakhtin, ou foi a fonte direta de inspiração para o primeiro e através dele para a teoria bakhtiniana. O estudo das ideias linguísticas do fi m do século XIX e início do século XX permite concluir que Volochinov e Bakhtin adotaram temas, problemáticas e noções da fi losofi a e das ciências humanas nascentes, porém transformaram o dado no novo.