bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Monitoring of Adalimumab at Non-Trough Levels to Gauge Its Efficacy in Patients with Inflammatory Bowel Disease in Clinical Practice
Authors: Masaichi Kato , Sugimoto Ken , Kentaro Ikeya , Ryosuke Takano , Ai Matsuura , Miyazu Takahiro , Ishida Natsuki , Tamura Satoshi , Tani Shinya , Yamade Mihoko , Hamaya Yasushi , Iwaizumi Moriya , Osawa Satoshi , Furuta Takahisa , Hiroyuki Hanai 
Published: October 2020

Abstract
Background: Adalimumab (ADA) trough level and anti-ADA antibody (AAA) positivity could influence mucosal healing and loss of response in patients with inflammatory bowel disease (IBD). This study aimed to clarify the correlation between ADA monitoring, including non-trough level and real-world IBD clinical outcomes.Methods: This retrospective, observational, single-center study included 19 patients with ulcerative colitis (UC) and 33 patients with Crohn’s disease (CD) treated with ADA from January 2007 to August 2018. Serum ADA and AAA levels were measured 4‒14 days after ADA administration.Results: The AAA positivity rate was 23.1% (12/52). The ADA continuity was higher in the AAA-negative group than in the AAA-positive group (P = 0.223). Receiver operating characteristic (ROC) analysis revealed that a serum AAA cut-off value of 9.2 µg/mL was associated with ADA continuity (area under the curve [AUC]: 0.767, 95% confidence interval [CI]: 0.636–0.899). The ADA level was significantly higher in the endoscopic remission group than in the non-remission group (12.4 vs. 6.4 µg/mL, P = 0.02). Based on the ROC curve analysis results of serum ADA level and endoscopic remission, the cut-off value of serum ADA level was set to 11.1 µg/mL (AUC: 0.716, 95% CI: 0.533–0.900).Conclusions: Regardless of infliximab administration history, under combined use of ADA with immunomodulators and AAA positivity, ADA continuity was significantly higher when the serum AAA level 4–14 days after ADA administration was ≥9.2 µg/mL. Furthermore, endoscopic remission can be expected with a serum ADA level of ≥11.1 µg/mL.
Prediction of Severe Cisplatin-Induced Neutropenia Using Serum Albumin Concentration: A Retrospective Study
Authors: Nakazawa Yusuke , Kageyama Akira , Kitamura Masaki , Mitsumori Norio , Kawakubo Takashi 
Published: October 2020

Abstract
Background: Hypoalbuminemia may occur in patients with gastric cancer because of reduced food intake and gastric dysfunction. Cisplatin that is used in the treatment of gastric cancer not only has gastrointestinal side effects but also has a high serum protein-bound fraction, which causes alteration in pharmacokinetics, especially reduction of serum albumin concentration that may increase the risk of cisplatin-induced neutropenia. Hence, alteration of serum albumin concentration poses a major safety issue during anticancer therapy. We examined whether fluctuations in serum albumin concentration is a risk factor for predicting the development of severe neutropenia.Methods: This retrospective study included patients with gastric cancer undergoing cisplatin plus S-1 combination therapy to analyze their serum albumin concentration and the frequency of grade 3–4 neutropenia. We then investigated the relationship between the serum albumin concentration before cisplatin administration in the treatment course during which the neutrophil count reached nadir and the neutrophil count fluctuation after cisplatin administration.Results: Grades 3–4 and 0–2 neutropenia developed in 24 and 48 patients, with a mean serum albumin concentration of 3.60 ± 0.54 and 3.77 ± 0.51 g/dL, respectively, before chemotherapy (P = 0.23). During chemotherapy when the neutrophil count reached nadir, the serum albumin concentration levels before cisplatin administration were 3.39 ± 0.60 and 3.85 ± 0.59 g/dL, respectively; the grade 3–4 neutropenia group had a significantly lower concentration of serum albumin than the grade 0–2 neutropenia group (P = 0.006). Lower serum albumin concentrations before cisplatin administration were significantly correlated with a decrease in neutrophil count after cisplatin administration (r = 0.463, P < 0.001). According to the receiver operating characteristic curve analysis, patients with serum albumin concentrations below 3.25 g/dL before cisplatin administration exhibited a significantly higher incidence of grade 3–4 neutropenia (odds ratio: 4.33). Conclusions: The risk of cisplatin-induced neutropenia is significantly high in patients with hypoalbuminemia. Thus, serum albumin concentration should be evaluated before cisplatin administration to anticipate the development of severe neutropenia.
Evaluation of Vital Signs’ Fluctuations and Behavioral Responses in the Assessment of Pain in Patients With Traumatic Brain Injury
Authors: ghanbari atefeh , Paryad Ezzat , safati Arefe , Leyli Ehsan Kazemnezhad , Parsasalkisari Elaheh 
Published: October 2020

Abstract
BackgroundTraumatic brain-injured (TBI) patients suffer severe pain. The assessment of behavioral responses and vital signs seems to be necessary for pain detection in these patients, a matter that this study aims to evaluate.MethodsThis cross sectional study uses repeated measures and included ninety-seven TBI patients from Poorsina hospital, Rasht, Iran. Patients’ relevant parameters were recorded using demographic checklist, specifications related to the disease, RASS, CPOT, and FPT tools. The data subsequently were entered into SPSS software V. 21 and were analyze using several tests including Bonferroni’s inferential test and Greenhouse-Geisser test, multiple analysis regression coefficient and general linear model by GEE method.ResultsThe average age of patients was 42.3 ± 18.2. The average consciousness level was 9.30 ± 2.96. There was significant difference between the painful and non-painful stimulations in heart rate, systolic blood pressure and diastolic blood pressure (p <0.001). Heart rate (p < 0.001, r = 0.253), number of respiration (p < 0.001, r = 0.173), systolic (p = 0.002, r = 0.128) and diastolic (p<0.001, r=0.223) blood pressures had a positive correlation with behavioral responses. However, the arterial oxygen saturation showed a negative correlation with behavioral responses (p < 0.001, r = -0.361). Statistical models demonstrated a significant direct relationship between CPOT with heart rate (β = 2.39, p < 0.001) and both systolic blood pressure (β= 1.31, p=0.002) and the fluctuations of diastolic blood pressure (β = 0.690, p = 0.009). ConclusionIt seems that behavioral responses are appropriate indices for pain detection. However, vital signs are not capable of being considered as proper indexes for pain assessment since they changed during several procedures while remained unchanged in other tests.
Unveiling real active site for photocatalytic H2O2 evolution: A combined experimental and DFT-TDDFT study
Authors: Luo Jun , Liu Yani , Fan Changzheng , Tang Lin , Yang Shuaijun , Liu Milan , Wang Mier , Feng Chengyang , Ouyang Xilian , Wang Lingling , Xu Liang , Wang Jiajia , Yan Ming 
Published: October 2020

Abstract
Photocatalyst with multiple modification sites (MSs) exhibited better performance than single site in photocatalytic H2O2 evolution, while the corresponding reaction mechanism is more complicated. However, neither experiment nor density functional theory (DFT) based on ground state wavefunction cannot precisely confirm the role of each site in photocatalyst with multiple MSs. Here, we propose a universal method that flexibly combines experiments, DFT and time-dependent DFT (TDDFT) calculations to reveal the photocatalytic mechanism and active site of nitrogen deficiency g-C3N4 (NDCN) containing two MSs (bicoordinated nitrogen vacancy and cyano group). Characterization techniques and control experiments prove that generation of H2O2 on NDCN is a two-step single electron transfer process, and NDCN exhibits enhanced charge separation efficiency and higher selectivity for two-electron oxygen reduction. DFT-TDDFT calculations further indicate that nitrogen vacancy is the real catalytic site for activating O2, which promotes O2 adsorption and continuously formation of •O2−, thus inhibiting electron-hole recombination.
Altered Cerebellum Spontaneous Activity in juvenile Autism Spectrum Disorders Associated with Cognitive Functions
Authors: Li Jinglun , Chen Xiu , Zheng Ruwen , Chen Ai , Zhou Yan , Ruan Jianghai 
Published: October 2020

Abstract
BackgroundAutism Spectrum Disorders (ASD) is a neurodevelopment disorder. The cerebellum has been reported to be one of the key regions involved in ASD. However, the associations between the cerebellum and clinical traits remain unclear. MethodsHere we performed Amplitude of Low Frequency Fluctuations (ALFF) analysis to detect the alterations of brain spontaneous activity in ASDs and explore the associations between spontaneous brain activity and clinical traits. ResultsCompared with normal controls, cerebellum crus 2 showed significantly weaker average ALFF values. Other regions such as left cerebellum 6, cerebellum vermis 4 5, putamen, SMA and thalamus showed increased mean ALFF values. In ASD patients with SRS total score T above 59, the mean ALFF values of cerebellum vermis 4 5 was significantly correlated with SRS total score T (r=0.175, P=0.031), SRS cognition score T (r=0.169, P=0.036) and SRS motivation score T (r=0.176, P=0.028).ConclusionsThese findings were not observed in other brain regions and in normal controls. Our study suggests a role of cerebellum in cognitive impairments in ASD and supports a mechanistic basis for the targeted treatment of ASD disorders.Trial registrationNot applicable.
Incidence and predictors of adverse pregnancy outcomes with maternal HIV-1 immune reconstitution inflammatory response syndrome among women within reproductive age in selected hospitals, Nairobi, Kenya (A prospective cohort study)
Authors: Muthuka John Kyalo , Kombe Yeri , Makokha Anselimo , Kiptoo Michael 
Published: October 2020

Abstract
Background: With enhanced rollout of anti-retroviral therapy (ART) following prevention of mother to child transmission (PMTCT) and the associated burden of opportunistic infections in developing countries, human immunodeficiency virus-immune reconstitution inflammatory syndrome (HIV-IRIS) may remain a public health area of major concern especially, in pregnancy. Ascertaining the association between maternal HIV infection and adverse maternal and birth related outcomes could be conflicted by the relationship between maternal-HIV- IRIS and the adverse pregnancy-fetal outcomes (APFOs) in HIV-infected mothers. We sought to estimate the incidence and determine possible predictors for adverse pregnancy-fetal outcomes with maternal-HIV-IRIS in ART naïve HIV infected pregnant women. Methodology: Subjects grouped in to IRIS exposed and non-IRIS exposed were followed from the end of first trimester for six and half months. Chi-square test was used to establish the association between the variables at p-value < 0.05. Regression analysis was performed to identify independent predictors of APFOs. Adjusted Relative Risk at 95% confidence interval was determined. Results: The IRIS exposed pregnant women, had a 26.47% adverse pregnancy-fetal outcomes cumulative incidence compared to 10.78% among IRIS non-exposed women. The APFO incidence rate estimate was 0.012 and 0.0045 per person’s week respectively. IRIS cases had 2.46 times the risk of experiencing an APFO compared to those who did not [OR=3; 95%CI: 1.4-6.4; P=.004], at bivariate analysis, not sustained at the multivariate analysis [AOR=1.6; 95%CI: 0.4-5.8; P = .508]. Multiple logistic regression dropped maternal HIV-IRIS and revealed; HIV-RNA viral load at baseline of above 50 copies/ml [AOR=2.7; 95%CI: 1.2-6.3; P=.017], Maternal placental syndrome(MPS) characterized by hypertensive event [AOR=0.1; 95%CI:0.0-1.0; P = .052] and mother’s general health during delivery [AOR= 4; 95%CI: 4.0:1.8-9.1;P=.001] as independent predictors of APFOs. Conclusion: There is a higher incidence of APFOs among maternal HIV-IRIS diagnosed pregnant women as compared to non-HIV maternal IRIS diagnosed pregnant women. In particular, MPS characterized by an hypertensive event, HIV-RNA viral load at baseline of above 50 copies/ml and mother’s general health during delivery are key predictors of an adverse pregnancy outcome. Interventions to reduce the associated risk predictors identified in this analysis should be studied for their effects on reducing APFOs.
Pregnancy outcomes of infertile women with co-existing endometriosis and adenomyosis after laparoscopic surgery: a long-term follow-up
Authors: Shi Jinghua , Dai Yi , Zhang Junji , Li Xiaoyan , Jia Shuangzhen , Leng Jinhua 
Published: October 2020

Abstract
Background: Adenomyosis and endometriosis are often co-existent. Laparoscopic surgery is one of the main methods to diagnose and treat these conditions. However, very few studies have been done that concentrate on the pregnancy outcomes of infertile women with both adenomyosis and endometriosis after laparoscopic surgery, as well as the relevant influential factors.Methods: This is a retrospective, cross-sectional study including infertile women diagnosed with endometriosis and adenomyosis. All patients had undergone laparoscopic surgery and were divided into two groups according to pregnancy outcomes. Demographic data, operation records, and pregnancy outcomes were collected.Results: Ninety-seven patients had live births, including 81 full-term and 16 preterm deliveries. The biochemical pregnancy, clinical pregnancy, and live birth rates were 80.87%, 67.4, and 55.11% respectively. One hundred thirty-five patients received IVF with 70 (51.85%) patients having live births. Age, size of endometrioma, and size of uterus were significantly lower in those who had a successful delivery. There was no statistical difference in symptoms except anemia (13.40% vs. 25.32%, p=0.044). The group that failed to have a live birth had a higher percentage of ovarian and peritoneal endometriosis (P<.05), while the distribution of deep infiltrating endometriosis and adenomyosis types were similar. Mean uterus diameter (OR: 0.636, 95% CI: 0.434-0.932, p = 0.020) and endometriosis fertility index (EFI) (OR:1.299, 95% CI: 1.101-1.531, p = 0.002) were significantly correlated with live births in the multivariate analysis.Conclusions: Endometriosis and adenomyosis have an adverse effect on fertility. IVF is an important technology improving pregnancy rate even after surgery. The size of the uterus and EFI were independent risk factors for pregnancy outcomes.
The association between COVID-19 data and meteorological factors in Indonesia
Authors: Supari  , Nuryanto Danang Eko , Setiawan Amsari Muzakir , Sopaheluwakan Ardhasena , AlFahmi Furqon , Hanggoro Wido , Gustari Indra , Safril Agus , Yunita Rezky , Makmur Erwin Eka Syahputra , Swarinoto Yunus 
Published: October 2020

Abstract
On March 2, 2020, the first Coronavirus Disease (COVID-19) case was reported in Jakarta, Indonesia. One and half month later (15/05/2020), the cumulative number of infection cases was 16496 with a total of 1076 mortalities. This study is aimed to investigate the possible role of weather in the early cases of COVID-19 incidence in six selected cities in Indonesia. Daily data of temperature and relative humidity from weather stations nearby each city were collected during the period 3 March - 30 April 2020, together with data of COVID-19 cases. Correlation tests and regression analysis were performed to examine the association of those two data series. In addition, we analysed the distribution of COVID-19 with respect to weather data to estimate the effective range of weather data supporting COVID-19 incidence. Our results reveal that weather data is generally associated with COVID-19 incidence. The daily average temperature (T-ave) and relative humidity (RH) presents significant positive and negative correlation with COVID-19 data, respectively. However, the correlation coefficients are weak with the strongest correlations found at 5 day lag time i.e. 0.37 (-0.41) for T-ave (RH). The regression analysis consistently confirmed this relation. The distribution analysis reveals that the majority of COVID-19 cases in Indonesia occurred in the daily temperature range of 25-31oC and relative humidity of 74-92%. Our findings suggest that COVID-19 incidence in Indonesia has a weak association with weather conditions. Therefore, non-meteorological factors seem to play a larger role and should be given greater consideration in preventing the spread of COVID-19.
Age and chest radiography as possible parameters for rapid triage in COVID-19 outbreak surge
Authors: Wycliffe Wei Enli , Heng Tan Cher , Chan Monica , TOng Tan Thuan , Pada Surinder Kaur , Archuleta Sophia , Tat Ooi Say , Jiashen Loh , Choon Raymond Fong Kok , Cheng Thoon Koh , Sun Louisa Jin , Vasoo Shawn , Lee Vernon JM , Sin Leo Yee , Lye David C , Toh Matthias PHS 
Published: October 2020

Abstract
BackgroundTo evaluate the utility of age and chest radiography(CXR) in triaging COVID-19 patients for hospitalization versus isolation in non-hospital facilities, we examined how age and CXR at diagnosis were associated with clinical needs from late-January to early-April. MethodsClinical status of all COVID-19 cases was monitored for national disease surveillance. Cases were isolated in hospitals until SARS-CoV-2 RNA was undetectable on PCR. Age and CXR results on admission were analysed for association with oxygen supplementation and mechanical ventilation, the outcomes of interest.ResultsTill 4 April 2020, there were 1,481 COVID-19 cases in Singapore. Overall, 11.4% required supplemental oxygen while 4.8% required mechanical ventilation and intensive care. The respective proportions increased to 40.9% and 16.5% for cases aged ≥70 years. As a predictor of subsequent mechanical ventilation, age had an area under the receiver operator characteristic curve(AUROC) of 0.772 (95%CI:0.699-0.845). A combined criterion of either an abnormal CXR or age≥55 years had a sensitivity of 86.7% and specificity of 58.0% for the same outcome. A similar performance was observed for predicting oxygen supplementation needs.ConclusionsAge and CXR at diagnosis may be valuable in excluding severe disease, allowing safe triage for isolation in non-hospital facilities.
Osteoma extenso em seio maxilar: Relato de caso
Authors: Suassuna Thalles Moreira , Abreu Nathalie Murielly Rolim , Do Nascimento Vanessa Lorena , Aguiar Ávilla Pessoa , Sampaio Fábio Correia , Ramos Júnior José Wilson Noleto 
Published: October 2020

Osteomas são tumores benignos, tem comportamento clínico variavel, mas normalmente exibe crescimento lento e assintomático, sendo muitas vezes diagnosticados apenas em exames radiográficos de rotina. Na variante endosteal pode encontrar-se centralmente ou dentro dos seios paranasais, sendo mais comum no seio frontal, seguido pelo etmoide, maxilar e esfenoidal. O objetivo desse trabalho é relatar um caso clínico de osteoma que acometeu o seio maxilar, e revisar os principais aspectos relacionados ao seu diagnóstico e tratamento.
Life-cycle costs approach for private piped water service delivery: a study in rural Viet Nam
Authors: Grant Melita , Foster Tim , Dinh Dao Van , Willetts Juliet , Davis Georgia 
Published: October 2020

Abstract
Sustaining rural water services in Viet Nam requires an improved understanding of the costs and relative opportunities, especially given the government's support for private sector involvement in expanding water schemes. In particular, the life-cycle costs associated with the delivery of safe and sustainable water services in rural Viet Nam, as indeed elsewhere, are not well known, potentially compromising their long-term sustainability. To address this gap, this study assessed the cost structures of 14 water schemes in Viet Nam managed by private enterprises. Results showed that both capital and operational expenditures varied widely across the schemes assessed, reflective of the diversity of the age and characteristics of the schemes studied. Twelve of the 14 schemes generated a cash profit in the most recent calendar year; however, when taking into account depreciation, as well as historical subsidies and connection fee payments, only four of the schemes were profitable based on a 20-year design life assumption. The study complements previous research demonstrating barriers to achieving universal access when relying on user-pays systems. The results provide a useful reference point to inform business planning for enterprises, as well as policy and support mechanisms important for securing sustainable rural water supply services.
Pendidikan pendahuluan bela negara melalui pendidikan kewarganegaraan
Authors: Dahliyana Asep , Nurdin Encep Syarif , Budimansyah Dasim , Suryadi Ace 
Published: October 2020

ABSTRAKPendidikan Kewarganegaraan di Indonesia memiliki beberapa fungsi salah satunya sebagai pendidikan pendahuluan bela negara. Namun dalam praktiknya, proses pembelajaran Pendidikan Kewarganegaraan di perguruan tinggi masih belum menemukan formula yang sesuai dengan konsep pendidikan bela negara untuk warga negara sipil. Penelitian ini bermaksud untuk menjelaskan peranan Pendidikan Kewarganegaraan dalam konteks pendidikan pendahuluan bela negara di perguruan tinggi. Metode yang digunakan dengan pendekatan mix method dengan the dominant less dominant antara wawancara dan survey yang dilakukan kepada 400 peserta didik dan 8 dosen. Proses pengambilan data dilakukan pada peserta didik Universitas Pendidikan Indonesia yang berasal dari 10 (sepuluh) program studi yang berbeda. Hasil penelitian menunjukkan bahwa Pendidikan Kewarganegaraan di perguruan memiliki pengaruh terhadap nilai-nilai bela negara dengan kisaran yang berbeda. Hal tersebut dikuatkan dengan hasil wawancara bahwa Pendidikan Kewarganegaraan dapat meningkatkan kecintaan dan motivasi untuk membela negara namun masih dalam tataran pemikiran berbentuk pengetahuan belum pada tataran tindakan. Oleh sebab, praktik dalam pendidikan pendahuluan bela negara tergantung dari perilaku peserta didik itu sendiri. Hal tersebut memiliki implikasi bahwa Pendidikan Kewarganegaraan sebagai pendidikan pendahuluan bela negara untuk warga negara sipil syarat nilai tanpa makna yang tidak berpengaruh terhadap perilaku warga negara sipil secara aktual karena masih berada pada tataran konsep dan pengetahuan peserta didik semata. ABSTRACTCivic Education in Indonesia has several goals, one of which is as primary education for the country's defense. Nevertheless, in practice, the Civic Education learning process in tertiary institutions has not yet found a formula that is in line with the concept of state defense education for civilians. This study intends to explain the role of Civic Education in the context of primary education in state defense in tertiary institutions. The mixed-method approach method with the dominant less dominant between interviews and surveys conducted to 400 students and eight lecturers. The data collection process was carried out on the students of Universitas Pendidikan Indonesia, who came from 10 (ten) different study programs. The study results illustrate that Civic Education in universities influences the values of defending the country with different ranges. The interview results confirmed that Civic Education can increase the love and motivation to defend the country but still at the level of thought in the form of knowledge, not at the level of action. Therefore, practice in primary education in state defense depends on the behavior of the students themselves. It implies that Civic Education as primary education for civilians' defense is a condition without meaning that does not affect civilians' actual behavior because it is still at the students' concepts and knowledge only.