bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selbsterfahrung in einer Verreibestudie
Authors: Kirch Rocco 
Published: March 2020

ZusammenfassungUnter der Annahme, dass bei der Verreibung einer Substanz zur Herstellung eines homöopathischen Mittels Symptome auftreten, die mit Symptomen korrespondieren, für die das Mittel – gemäß dem Simile-Prinzip – eingesetzt wird, müsste es möglich sein, unter Blindbedingungen eine verriebene Substanz von verriebenem Placebo zu unterscheiden. Während einer „Verreibungsstudie“ wurden von 11 Teilnehmern, die mit der Probe Natrium sulfuricum („Verum“) und von 13 Teilnehmern, die im gleichen Raum mit der Probe Saccharum lactis („Placebo“) beschäftigt waren, subjektiv auftretende Symptome beobachtet und protokolliert. Im quantitativen Vergleich fiel auf, dass die Verumgruppe mit 55 Symptomen weniger Items anführte (5,0 / TN) als die Placebogruppe mit 114 Symptomen (8,7 / TN). Das Verum Natrium sulfuricum konnte nicht identifiziert werden. Die deutlich größere Anzahl von Symptomen der Placebogruppe gegenüber der Verumgruppe, wie die Frage nach möglichen Kontextfaktoren könnten in weiteren Untersuchungen betrachtet werden.
Übereinstimmung pränatal erhobener homöopathischer Arzneimittelbilder mit der Erstanamnese des Kindes
Authors: Schmitt Sandra , Mosgöller Wilhelm , Christian Endler P 
Published: March 2020

ZusammenfassungNach Ansicht verschiedener homöopathischer Schulen können Beobachtungen während der Schwangerschaft die Sicherheit bei der späteren Arzneimittelverschreibung für das Kind erhöhen. In einer Vorstudie zeigte sich, dass bei Schwangeren neue, bisher unbekannte Symptome und daraus resultierende Arzneimittelbilder auftreten. Im aktuellen Projekt wurde untersucht, ob sich diese neu aufgetretenen Arzneimittelbilder in den geborenen Kindern wiederfinden. Gegebenenfalls werden durch die Anamnese der Schwangeren Hinweise für die homöopathischen Arzneiverordnungen von Säuglingen und Kleinkindern gesammelt. Als Basis wurde zu jedem Kind ein personalisierter Fragebogen mit körperlichen, mentalen und allgemeinen Symptom erstellt, der durch die Mutter bearbeitet wurde. Zusätzlich wurde eine praxisübliche homöopathische Erstanamnese des Kleinkindes durchgeführt. Auf diese Art wurden 13 Kinder von 13 Müttern untersucht. Die statistische Analyse betrachtete, ob sich das bei der Schwangeren pränatal durch eine homöopathische Anamnese festgestellte 1. Arzneimittel postnatal wiederfindet. Zusammenfassend zeigte sich, dass eine Anamnese bei Schwangeren als erste Orientierungshilfe für die spätere Wahl homöopathischer Arzneimittel für das Kind dienen kann.
Symbioselenkung bei homöopathisch behandelten Patienten mit komplexen Pathologien
Authors: Chammah Ina 
Published: March 2020

ZusammenfassungNach einer Einführung in einige Schlüsselfunktionen des Mikrobioms wird die heute mögliche Diagnostik und Therapie des Mikrobioms zusammenfassend beschrieben. Anhand von 3 Kasuistiken wird die sogenannte „Symbioselenkung“ dargestellt und wie sie während oder vor der homöopathischen Behandlung komplexer Krankheitsbilder den Therapieverlauf positiv beeinflussen kann. Dabei kann gezeigt werden, dass neben Darmbeschwerden auch auf psychische Veränderungen, Allergien, autoimmune Geschehen und Hauterkrankungen positiver Einfluss genommen werden kann.
Arbeitsbezogene Teilhabebeeinträchtigungen und Unterstützungsbedarf von Patienten in der (teil-)stationären psychiatrischen Versorgung
Authors: Jäckel Dorothea , Siebert Stefan , Baumgardt Johanna , Leopold Karolina , Bechdolf Andreas 
Published: March 2020

Zusammenfassung
Ziel Rund 80 % der Patienten in psychiatrischen Kliniken haben wesentliche arbeitsbezogene Teilhabebeeinträchtigungen und sind vom Arbeitsmarkt ausgeschlossen.
Methode Stichtagsbefragung von 176 Patienten in (teil-)stationärer Behandlung bzgl. ihrer arbeitsbezogenen Teilhabebeeinträchtigungen, ihres Unterstützungsbedarfs und konkret erhaltener Hilfe.
Ergebnisse Von 90 der 176 angefragten Patienten lagen Daten vor. 63 % der Patienten (n = 57) gaben Unterstützungsbedarf an; von diesen würden 84 % an einem Jobcoaching teilnehmen. 49 % der Patienten wurden auf das Thema Arbeit angesprochen. Unabhängig vom Unterstützungsbedarf erhielten nur 20 % der Patienten konkrete Hilfe. Starken Unterstützungsbedarf gaben junge Erwachsene (77 %) und Ersterkrankte (73 %) an.
Schlussfolgerungen Es gibt einen hohen, aber unzureichend gedeckten Unterstützungsbedarf. Die routinemäßige Bedarfsermittlung und die Implementierung evidenzbasierter Methoden könnten arbeitsbezogene Teilhabechancen wesentlich verbessern.
Auswirkungen der Etablierung des psychiatrischen Behandlungskonzepts „Weddinger Modell“ auf mechanische Zwangsmaßnahmen
Authors: Czernin Klara , Bermpohl Felix , Heinz Andreas , Wullschleger Alexandre , Mahler Lieselotte 
Published: March 2020

Zusammenfassung
Ziel Die Auswirkung des Recovery-orientierten psychiatrischen Behandlungskonzepts „Weddinger Modell“ wurde auf den Einsatz von mechanischen Zwangsmaßnahmen (ZM) untersucht.
Methodik Mittels einer retrospektiven Fallkontrollstudie wurden zwei Patientengruppen analysiert: Eine wurde nach dem Weddinger Modell behandelt (Interventionsgruppe; n = 122), die andere konventionell (Kontrollgruppe; n = 235).
Ergebnisse In der Interventionsgruppe zeigte sich eine signifikante Reduktion der maximalen Fixierungsanzahl und der Isolierungsdauer.
Schlussfolgerung Die Implementierung des Weddinger Modells kann einen positiven Beitrag zur Zwangsreduktion leisten.
The Impact of Assisted Reproductive Technology in Twin Pregnancies Complicated by Intrahepatic Cholestasis of Pregnancy: a Retrospective Cohort Study
Authors: Çelik Samettin , Çalışkan Canan 
Published: March 2020

Abstract
Introduction Our study aims to evaluate the perinatal outcomes in twin pregnancies diagnosed with intrahepatic cholestasis of pregnancy (ICP) and to compare these with normal healthy twin pregnancies for perinatal outcomes. The second outcome of the study was to determine whether in vitro fertilization-embryo transfer (IVF-ET) affects the perinatal outcome in ICP patients.
Materials and Methods In this study, 59 ICP and 641 healthy twin pregnancies were compared for perinatal outcomes retrospectively. According to the mode of conception, the twin pregnancies with ICP were divided into 2 groups. The twin pregnancies with ICP who were conceived with IVF were referred to as the IVF-ET group. The twin pregnancies with ICP who were conceived spontaneously or by ovulation induction and intrauterine insemination (IUI) were referred to as the non-IVF-ET group.
Results Twin pregnancies with ICP give birth significantly earlier than normal twin pregnancies (p ˂ 0.001). The diagnosis of ICP occurred significantly earlier in the IVF-ET pregnancy with ICP than in the non-IVF-ET group. In twin pregnancies with IVF-ET, patients delivered significantly earlier than in the non-IVF-ET group (p=0.002). Twin pregnancies with ICP were found to have significantly higher rates of meconium-stained amniotic fluid, postnatal intubation, and admission to the neonatal intensive care unit (NICU) than healthy twin pregnancies.
Conclusions ICP is a risk factor for preterm delivery in twin pregnancies. In addition, ICP develops earlier and more frequently in twin pregnancies from IVF-ET than in those from non-IVF twin pregnancies, and the disease may be more serious.
Cervical and Lower Uterine Parameter Ultrasound and Elastographic Parameters for the Prediction of a Successful Induction of Labor
Authors: Hamza Amr , Radosa Julia , Gerlinger Christoph , Solomayer Erich Franz , Ströder Russalina , Meyberg-Solomayer Gabriele 
Published: March 2020

Abstract
Purpose The prediction of successful induction of labor (IOL) has been the subject of a series of studies. The predictive role of cervical sonographic and elastographic parameters has been controversially discussed. Lower uterine segment (LUS) thickness and strain values have not been discussed yet in this regard.
Materials and Methods A prospective cohort study was performed to examine the predictive power of Bishop score parameters, sonographic cervical length (CL), cervical funneling, cervical strain values, LUS thickness and its strain values regarding successful IOL within 24 hours and intervals to onset of labor, ROM and delivery of the fetus. A p-value of < 0.05 was considered statistically significant.
Results 135 patients were examined. A cervical length of 25 mm, the presence of cervical funneling and digital shorter cervix was significant for the prediction of successful induction of labor (IOL) within 24 hours. There was weak correlation between the functional CL and the onset of labor (r2 = 0.10) and ROM (r2 = 0.13). There was also a weak correlation between the cervical funnel width and the time interval to the onset of labor (r2 = 0.25), ROM (r2 = 0.23) and delivery of the fetus (r2 = 0.22). Cervical elastography, LUS thickness and strain values were not significant for the prediction of a successful IOL.
Conclusion We were able to show that cervical structural changes at the level of the internal os, i. e., shortening through funneling, may be the determining factor for successful IOL.
Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway
Authors: Alam Mahtab , Zameer Saima , Najmi Abul Kalam , Ahmad Farhan Jalees , Imam Syed Sarim , Akhtar Mohd 
Published: March 2020

AbstractThe World Health Organization (WHO) has ranked depression the 4th leading cause of disability worldwide. Thymoquinone (TQ), is an active constituent of Nigella sativa having various medicinal properties but has poor solubility and bioavailability. This problem was overcome by developing nanoformulation of TQ. Previously TQ reported good antioxidant and anti-inflammatory effects. Recently TQ’s anti-depressant effect was demonstrated. However, the mechanisms underlying the antidepressant effect of TQ still needs evaluation. Activation of Indoleamine-2,3-dioxygenase (IDO), (an enzyme that participates in the tryptophan metabolism), leads to a decrease of serotonin (5-HT) levels. The expression of this enzyme is associated with immune system activation, which has been proposed as a common mechanism that links depression. The present study was performed in stressed animals where hippocampal levels of pro-inflammatory cytokines (IL-6 and TNF α levels), brain derived neurotropic factor (BDNF) and hippocampal kynurenine (KYN), tryptophan (TRP) and serotonin (5-HT) levels were estimated. Treatment with TQ solid lipid nanoparticles (TQSLN 20 mg/kg p.o) and TQ suspension (20 mg/kg p.o) demonstrated antidepressant-like activity in chronic forced-swim stress model. Further, it reduced the elevated hippocampal IL-6 & TNFα and reversed the increased activity of IDO as measured by ratio of hippocampal KYN/TRP and 5HT/TRP in stressed rats. The results of the present study confirm anti-inflammatory and neuroprotective effects of TQ which may be associated with 5-HT pathway. Thus, the present study offers a newer approach to reduce symptoms of depression using TQSLN. Our results are preliminary, further research is needed for more conclusive view.
Pneumothorax and Pregnancy: A Systematic Review of the Current Literature and Proposal of Treatment Recommendations
Authors: Agrafiotis Apostolos C. , Assouad Jalal , Lardinois Inès , Markou Georges A. 
Published: March 2020

AbstractIntroduction Spontaneous pneumothorax occurs rarely during pregnancy with less than 100 cases reported in the English literature. There is no strong evidence concerning the treatment of spontaneous pneumothorax during pregnancy and labor. The aim of this study is to systematically review all the reported cases and to suggest recommendations for its diagnosis and treatment.Methods A PubMed research was conducted. The following data were collected: maternal age, gestation age (weeks), presence of underlying lung pathology, initial management, definitive management, obstetric outcome, and the complications for the mother and the fetus.Results Eighty-seven cases were identified. The mean maternal age was 27 years (standard deviation [SD] ± 6). The mean gestational age was 25 weeks (SD ± 11.4). In 37.9% of cases, there was no underlying lung disease. In the majority of cases (67.4%), the initial treatment was the placement of a chest tube. In 48% of cases, the pneumothorax was resolved with conservative treatment. Surgical therapy was performed either antepartum or postpartum. In 58.6% of cases, there was a vaginal delivery, spontaneous or instrumental. In three cases (3.4%), there were fetal complications.Conclusion The analysis of the current literature provides low evidence, since there are only case reports and small case series. It is likely that the frequency of this condition is underestimated. However, this analysis permits to draw some conclusions concerning the timing of pneumothorax treatment, the operative strategy, and the mode of delivery to decrease the risk for the mother and the fetus.
Double Antithrombotic versus Triple Antithrombotic Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome
Authors: Dharma Surya 
Published: March 2020

AbstractIn atrial fibrillation (AF), oral anticoagulant (OAC) therapy with either vitamin K antagonist or non–vitamin K antagonist is used to prevent thromboembolic complications. In patients who presented with acute coronary syndrome (ACS) and were treated by percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor reduces major adverse cardiac events (MACEs) and stent thrombosis. Consequently, in patients with AF who presented with ACS and were treated by PCI, the combination of OAC and DAPT, the so-called triple antithrombotic therapy (TAT) is needed to improve the outcome of the patients. However, the use of TAT increases the risk of bleeding. Several randomized clinical trials and a meta-analysis evaluated the use of TAT and double antithrombotic therapy (DAT) in this population, and DAT is defined as patients who receive combination of one antiplatelet and OAC. In general, the studies demonstrated a reduction in bleeding event in patients who received DAT as compared with TAT, with similar incidence of thromboembolic complications and MACE. To date, there is no established consensus or guideline for the most appropriate combination of antithrombotic agents in patients with AF and ACS who undergo PCI. Tailoring the treatment for each individual is likely the best approach to determine the balance of bleeding risk and ischemic events before starting antithrombotic therapy. Future trials with adequate sample size are needed to find the most appropriate combination of antiplatelet and OAC in patients with AF who presented with ACS and treated by PCI.
Giant Intramural Right Ventricular Hematoma after PCI in a Patient with Condition after CABG
Authors: Vondran Maximilian , Ghazy Tamer , Andrási Terezia Bogdana , Graff Jürgen , Rastan Ardawan Julian 
Published: March 2020

AbstractCoronary artery perforation secondary to percutaneous coronary intervention (PCI) is a rare, but a potentially life-threatening complication. There is a misconception that cardiac tamponade rarely occurs in patients with prior coronary artery bypass grafting (CABG). We first describe a giant right ventricular intramural hematoma following PCI via a saphenous vein graft to treat a distal stenosis of the right coronary artery, and its successful treatment with redo cardiac surgery. Complex elective PCIs on patients after CABG should be performed in specialized centers with a well-established heart team that has the expertise to treat any of the potential complications.
Customized versus Population Growth Standards for Morbidity and Mortality Risk Stratification Using Ultrasonographic Fetal Growth Assessment at 22 to 29 Weeks' Gestation
Authors: Blue Nathan R. , Grobman William A. , Larkin Jacob C. , Scifres Christina M. , Simhan Hyagriv N. , Chung Judith H. , Saade George R. , Haas David M. , Wapner Ronald , Reddy Uma M. , Mercer Brian , Parry Samuel I. , Silver Robert M. 
Published: March 2020

Abstract
Objective The aim of study is to compare the performance of ultrasonographic customized and population fetal growth standards for prediction adverse perinatal outcomes.
Study Design This was a secondary analysis of the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be, in which l data were collected at visits throughout pregnancy and after delivery. Percentiles were assigned to estimated fetal weights (EFWs) measured at 22 to 29 weeks using the Hadlock population standard and a customized standard (www.gestation.net). Areas under the curve were compared for the prediction of composite and severe composite perinatal morbidity using EFW percentile.
Results Among 8,701 eligible study participants, the population standard diagnosed more fetuses with fetal growth restriction (FGR) than the customized standard (5.5 vs. 3.5%, p < 0.001). Neither standard performed better than chance to predict composite perinatal morbidity. Although the customized performed better than the population standard to predict severe perinatal morbidity (areas under the curve: 0.56 vs. 0.54, p = 0.003), both were poor. Fetuses considered FGR by the population standard but normal by the customized standard had morbidity rates similar to fetuses considered normally grown by both standards.The population standard diagnosed FGR among black women and Hispanic women at nearly double the rate it did among white women (p < 0.001 for both comparisons), even though morbidity was not different across racial/ethnic groups. The customized standard diagnosed FGR at similar rates across groups. Using the population standard, 77% of FGR cases were diagnosed among female fetuses even though morbidity among females was lower (p < 0.001). The customized model diagnosed FGR at similar rates in male and female fetuses.
Conclusion At 22 to 29 weeks' gestation, EFW percentile alone poorly predicts perinatal morbidity whether using customized or population fetal growth standards. The population standard diagnoses FGR at increased rates in subgroups not at increased risk of morbidity and at lower rates in subgroups at increased risk of morbidity, whereas the customized standard does not.
The Impact of Previous Obstetric History on the Risk of Spontaneous Preterm Birth in Women with a Sonographic Short Cervix
Authors: Dude Carolynn M. , Levine Lisa D. , Schwartz Nadav 
Published: March 2020

AbstractObjective The natural history of women with a short cervix and a low-risk obstetric history remains poorly defined. In our study, we sought to better characterize the impact of previous obstetric history on the delivery outcomes in women diagnosed with a mid-trimester sonographic short cervix.Study Design We performed a retrospective cohort study of women with singleton gestations who underwent transvaginal cervical length screening between 16 and 24 weeks at two urban hospitals in Philadelphia between January 2013 and March 2018 and were found to have a short cervix (defined as ≤2 cm). Women were excluded from the cohort if there were major fetal anomalies noted or if delivery outcome information was not available. The cohort was then divided into three groups based on obstetric history: nulliparous, history of full-term birth only, or history of spontaneous preterm birth (sPTB). The primary outcome was sPTB <37 weeks, while the secondary outcome was sPTB <34 weeks.Results Our cohort included a total of 384 singleton pregnancies that were diagnosed with a sonographic short cervix: 165 women were nulliparous, 119 women had a history of full-term birth, and 100 women with a history of sPTB. We found that women with a short sonographic cervix had a sPTB rate of 39.6% with no differences found between the three groups. Only two-thirds of nulliparous women and women with a history of full-term birth received the recommended preventative treatment, compared with almost 100% of women with a history of sPTB.Conclusion Women with and without a history of sPTB are at comparable risk of sPTB in the presence of a sonographically short cervix. Preventative therapies should be recommended to both nulliparous women and women with a history of full-term birth since uptake in this population are not as high.
Effects of Single Loading Dose of Intravenous Caffeine on Cerebral Oxygenation in Preterm Infants
Authors: Ilhan Ozkan , Bor Meltem 
Published: March 2020

Abstract
Objective The aim of this study was to evaluate the effects of caffeine on cerebral oxygenation in preterm infants.
Study Design This was a prospective study of infants with a gestational age (GA) of < 34 weeks who were treated intravenously with a loading dose of 20 mg/kg caffeine citrate within the first 48 hours of life. Regional cerebral oxygen saturation (rSO2C) and cerebral fractional tissue oxygen extraction (cFTOE) were measured using near-infrared spectroscopy before administering caffeine (baseline), immediately after administering caffeine, and 1, 2, 3, 4, 6, and 12 hours after dose completion; postdose values were compared with the baseline values.
Results A total of 48 infants with a mean GA of 29.0 ± 1.9 weeks, birth weight of 1,286 ± 301 g, and postnatal age of 32.4 ± 11.3 hours were included in the study. rSO2C significantly decreased from 81.3 to 76.7% soon after administering caffeine, to 77.1% at 1 hour, and to 77.8% at 2 hours with recovery at 3 hours postdose. rSO2C was 80.2% at 12 hours postdose. cFTOE increased correspondingly. Although rSO2C values were lower and cFTOE values were higher compared with the baseline values at 3, 4, 6, and 12 hours after caffeine administration, this was not statistically significant.
Conclusion A loading dose of caffeine temporarily reduces cerebral oxygenation and increases cerebral tissue oxygen extraction in preterm infants. Most probably these changes reflect a physiological phenomenon without any clinical importance to the cerebral hemodynamics, as the reduction in cerebral oxygenation and increase in cerebral tissue oxygen extraction remain well within acceptable range.
The syntactic status of English dative alternation structures in bilingual and in monolingual acquisition data
Authors: Fernández Fuertes Raquel , Sánchez Calderón Silvia 
Published: March 2020

Abstract
This study deals with the syntactic (non-)derivational relationship of English dative alternation (DA) –double object constructions (DOCs) and to/for-datives–, as seen in the spontaneous production of English-Spanish bilinguals when compared to English monolinguals. While a chronological progression and a difference in use between the two English DA constructions could suggest a syntactic-derivational relationship between DOCs and to/for-datives, a fairly similar emergence and a possibly similar rate of use could point to the two constructions not displaying a syntactic-derivational status. We also explore whether English-Spanish bilinguals show divergent developmental paths when compared to English monolinguals. To address these issues, we analyze data from nine English-Spanish bilingual children and twelve English monolingual children, along with the adults interacting with them. The analysis shows that both DA structures emerge at a similar age, which suggests they are not syntactically derived from one another. Despite these differences, the later onset and the lower incidence of to/for-datives could be associated with the case and theta role mediated properties of prepositions as well as with the frequency of exposure to DA in the adults’ speech. As no differences appear between bilinguals and monolinguals, transfer from Spanish does not seem to be an issue.