bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional Receptor with Tunable Selectivity: A Comparative Recognition Profile of Organic Nanoparticles with Carbon Dots
Authors: Kaur Gaganpreet , Kaur Harpreet , Singh Amanpreet , Chaudhary Monika , Kaur Navneet , Singh Narinder , Jena Kailash C. 
Published: May 2020

AbstractThe exponential growth in the research field of water pollution control demands the evolution of novel sensing materials for regulation and quantification of metals ions. Within this context, the current work reports a new strategy for the synthesis of carbon dots from the hydrothermal treatment of organic nanoparticles. The organic nanoparticles are found to be selective towards Cs(I) ions with a detection limit of 5.3 nM, whereas the highly fluorescent carbon dots are found to be selective towards Ag(I) ions with a detection limit of 4.8 nM. Both sensing systems illustrate rapid sensing with a working pH range from 4–9. The interfacial molecular restructuring of the sensing systems in the aqueous phase has been investigated in the absence and presence of targeted metal ions using a sum frequency generation vibrational spectroscopic tool. The practical applicability of the sensors was checked in environmental samples. This work opens new avenues for the exploration of temperature‐guided sensing modulation in nanomaterials.
Concomitant lansoprazole ameliorates cisplatin‐induced nephrotoxicity by inhibiting renal organic cation transporter 2 in rats
Authors: Hiramatsu Shun‐ichi , Ikemura Kenji , Fujisawa Yutaka , Iwamoto Takuya , Okuda Masahiro 
Published: May 2020

AbstractCisplatin is used widely for the treatment of multiple solid tumors. Cisplatin‐induced nephrotoxicity is caused by renal accumulation of cisplatin via human organic cation transporter 2 (hOCT2). As lansoprazole, a proton pump inhibitor, is known to inhibit hOCT2 activity, lansoprazole might ameliorate cisplatin‐induced nephrotoxicity. A previous study showed that concomitant lansoprazole administration ameliorated nephrotoxicity in patients receiving cisplatin. However, the detailed mechanism remains to be clarified. In the present study, the drug–drug interaction between lansoprazole and cisplatin was examined using hOCT2‐expressing cultured cells and rat renal slices. Moreover, the effect of lansoprazole on cisplatin‐induced nephrotoxicity and the pharmacokinetics of cisplatin in rats was investigated. In the uptake study, lansoprazole potently inhibited the uptake of cisplatin in hOCT2‐expressing cultured cells and rat renal slices. The in vivo rat study showed that concomitant lansoprazole significantly ameliorated cisplatin‐induced nephrotoxicity and reduced the renal accumulation of platinum up to approximately 60% of cisplatin alone at 72 h after cisplatin intraperitoneal administration. Furthermore, the renal uptake of platinum at 3 min after intravenous cisplatin administration in rats with cisplatin and lansoprazole decreased to 78% of rats with cisplatin alone. In addition, there was no significant difference in the plasma platinum concentration between rats treated with and without lansoprazole at 3 min after cisplatin intravenous administration. These findings suggested that concomitant lansoprazole ameliorated cisplatin‐induced nephrotoxicity by inhibiting rOCT2‐mediated cisplatin uptake in rats, thus decreasing cisplatin accumulation in the kidney. The present findings provided important information for the establishment of novel protective approaches to minimize cisplatin‐induced nephrotoxicity.
A strategy for qualitative and quantitative profiling of Angelicae Pubescentis Radix and detection of its analgesic and anti‐inflammatory components by spectrum–effect relationship and multivariate statistical analysis
Authors: Hou Ajiao , Yang Liu , Zhang Jiaxu , Wang Song , Man Wenjing , Guo Xinyue , Yang Bingyou , Kuang Haixue , Li Bo , Wang Qiuhong , Jiang Hai 
Published: May 2020

AbstractThis study established a spectrum–effect relationship method for screening and quantifying the analgesic and anti‐inflammatory active ingredients in Angelicae Pubescentis Radix (AP) by ultra‐high‐performance liquid chromatography–quadrupole mass spectrometry detector analysis (UPLC–QDA). First, the fingerprint of AP was established to determine the common peaks. Next, six batches of AP samples, with significant differences, were selected for evaluation of pharmacological activity. Subsequently, the spectrum–effect relationship was used to screen the active ingredients. Finally, the screened ingredients were quantified using UPLC–QDA. In total, 21 common peaks were identified and four effective compounds (bergapten, columbianetin acetate, osthole and isoimperatorin) were selected using the gray relational analysis and partial least squares regression analysis. Quantitative analysis showed that the content of the four effective compounds was the highest in a randomly selected batch, S7 (Hubei). To our knowledge, this is the first attempt that evaluated the quality and spectrum–effect relationship of AP by quantitative analysis and chemometrics. This study identified the key pharmacologically active components of AP and thereby improved the quality evaluation system of AP. This method has broad application prospects for screening effective components and will be helpful in establishing more reliable, scientific and reasonable quality standards for AP and other traditional Chinese medicines.
Limb‐shaking transient ischemic attack with facial muscles involuntary twitch successfully treated with internal carotid artery stenting
Authors: Han Yuan‐yuan , Qi Dong , Chen Xiao‐Dong , Song Chun‐Jie 
Published: May 2020

AbstractIntroductionLimb‐shaking transient ischemic attack (LS‐TIA) is a clinical disease with severe carotid stenosis, which is characterized by unilateral rhythmic dance or tremor like involuntary movements of arms and/or legs, but facial muscles are usually unaffected.MethodsToday, we report a 42‐year‐old man with transient ischemic attack who suffered from right limb shaking and right facial muscle twitching due to the obvious stenosis of left internal carotid artery (ICA). Written informed consent was obtained from participants according to the Declaration of Helsinki, and a local ethic committee approved the study. ICA angioplasty and stent implantation were performed as treatment attempts. A brain protection device was navigated through the lesion and placed at the distal end of the stenosis.ResultThe patient successfully completed the recanalization through stent placement, and the involuntary shaking of limbs and face was improved. During the 3‐month follow‐up, the patient's symptoms disappeared completely and did not attack again.ConclusionThis case report highlights the importance of accurate diagnosis and treatment, because treatment‐related carotid artery occlusion can not only eliminate the attack, but also reduce the risk of future stroke.
Rebuilding the Interproximal Papilla: Description of “Tube” Technique and Two Case Reports
Authors: Kashani Hooshang , Vora Manali V. , Kuraji Ryutaro , Brody Hanna , Kapila Yvonne L. 
Published: May 2020

IntroductionPapilla reconstruction relies on similar principles as those applied to soft tissue grafting for recession defects; however, it is uniquely challenging from a surgical perspective because of the small size and lack of a blood supply. Several techniques have been used to reconstruct lost papilla; however, there are no prescribed techniques for this specific application.Case PresentationThis report describes a novel technique, herein called, the “tube technique” for treating interproximal recession and reconstructing the interproximal papilla, and documents two cases using the tube technique. An increase in attachment levels was observed in Case 1 (5 mm) and in Case 2 (4 mm) after using this surgical technique for papilla reconstruction.ConclusionThe tube grafting technique requires technical precision. Although when executed carefully, it results in predictable reconstruction of the interproximal papilla. Use of the tube technique helps mitigate issues associated with inadequate flap thickness, blood supply, and flap retraction.
Naphthalenones and Naphthols Isolated from the Saussurea laniceps Endophytic Fungus Didymella glomerata X223
Authors: Luo Gangyuan , Chen Senhua , Yu Jianchen , Yuan Jie , Zheng Li , Liu Lan , Chen Bin , Li Jing 
Published: May 2020

AbstractOne new naphthalenone, didymelol A, and three new naphthols, didymelol B–D, together with three known naphthalenones, (3S,4R)‐3,4,6‐trihydroxy‐3,4‐dihydronaphthalen‐1(2H)‐one, (4S)‐4,6‐dihydroxy‐3,4‐dihydronaphthalen‐1(2H)‐one, (4S)‐4‐hydroxy‐3,4‐dihydronaphthalen‐1(2H)‐one, were isolated from the Saussurea laniceps endophytic fungus Didymella glomerata X223. The structures of the isolates were elucidated based on extensive spectroscopic data analysis. The absolute configuration of didymelol A was established through single‐crystal X‐ray diffraction data and didymelols B–D were identified through comparisons of experimental and calculated ECD spectra. All compounds were evaluated for cytotoxic activity against human non‐small cell lung cancer A549 cells and human breast carcinoma MDA‐MB‐435 cells.
Increased Lipophilicity of Halogenated Ruthenium(II) Polypyridyl Complexes Leads to Decreased Phototoxicity in vitro when Used as Photosensitizers for Photodynamic Therapy
Authors: Roy Saonli , Colombo Elisa , Vinck Robin , Mari Cristina , Rubbiani Riccardo , Patra Malay , Gasser Gilles 
Published: May 2020

AbstractIn the fight against cancer, photodynamic therapy is generating great interest thanks to its ability to selectively kill cancer cells without harming healthy tissues. In this field, ruthenium(II) polypyridyl complexes, and more specifically, complexes with dipyrido[3,2‐a:2’,3’‐c]phenazine (dppz) as a ligand are of particular interest due to their DNA‐binding and photocleaving properties. However, ruthenium(II) polypyridyl complexes can sometimes suffer from low lipophilicity, which hampers cellular internalisation through passive diffusion. In this study, four new [Ru(dppz‐X2)3]2+ complexes (X=H, F, Cl, Br, I) were synthesized and their lipophilicity (logP), cytotoxicity and phototoxicity on cancerous and noncancerous cell lines were assessed. This study shows that, counterintuitively, the phototoxicity of these complexes decreases as their lipophilicity increases; this could be due solely to the atomic radius of the halogen substituents.
Mid‐term clinical outcomes from use of Sirolimus coated balloon in coronary intervention; data from real world population
Authors: Basavarajaiah Sandeep , Athukorala Sampath , Kalogeras Konstantinos , Panoulas Vasileios , Loku Waduge Bhagya H. , Bhatia Gurbir , Watkin Richard , Pulikal George , Lee Kaeng , Ment Jerome , Freestone Bethan , Pitt Michael 
Published: May 2020

AbstractBackgroundUse of drug coated balloons (DCBs) in coronary intervention is escalating. There is a plethora of data on Paclitaxcel‐DCB. However, when it comes of stents, Limus‐drugs are preferred over Paclitaxel. There is very limited data on Sirolimus coated balloons (SCB). MagicTouch‐SCB (Concept Medical, FL) elutes Sirolimus via nano‐technology and have been used in our centers since March 2018. We report a mid‐term follow‐up with this relatively novel‐technology.Methods and resultsWe retrospectively analyzed all patients treated with MagicTouch‐SCB between March‐2018 and February‐2019. Results are reported as cardiac‐death, target‐vessel myocardial‐infarction (TVMI), target lesion revascularization (TLR) and Major Adverse Cardiac Events (MACE). During the study period, 288‐patients (373‐lesions) with a mean age of 65.8 were treated with MagicTouch‐SCB. 84% (n = 241) were male, 155 (54%) were in the setting of acute coronary syndrome, 38% (n = 110) had diabetes and 62% (n = 233) were in de‐novo lesions. Most lesions treated were in the LAD/diagonal‐system (n = 170; 46%). Pre‐dilatation was performed in 92% (n = 345) of cases. Bailout stenting was required in 9% lesions (n = 35). The mean diameter and length of SCBs were 2.64 ± 0.56 mm and 24 ± 8.9 mm respectively.During a median follow‐up of 363 days (IQR: 278–435), cardiac death and TVMI occurred in 5‐patients (1.7%) and 10‐patients (3.4%) respectively, TLR per‐lesion was 12%. The MACE rate was 10%. There were no documented cases of acute vessel closure.ConclusionsThe results from mid‐term follow‐up with this relatively new technology SCB is encouraging with a low rates of hard endpoints and acceptable MACE rates despite complex group of patients and lesion subsets.
Hybrid approach to postmyocardial infarction ventricular septal defect repair
Authors: Alsaad Ali A. , Russell Hyde M. , Tokarczyk Arthur J. , Ricciardi Mark J. 
Published: May 2020

AbstractPostinfarction ventricular septal rupture is a rare and devastating complication of myocardial infarction. Despite attempts at acute surgical and percutaneous defect closure, morbidity and mortality remain high. Herein, we describe a hybrid surgical and catheter‐based approach to defect closure in a 63‐year‐old woman with postinfarction ventricular septal rupture and cardiogenic shock.
Brief soaking at above‐gelatinization temperature reduces inorganic arsenic in cooked rice
Authors: Chen Guoying , Lai Bunhong , Chen Tuanwei , Lin Hetong , Mao Xuefei 
Published: May 2020

AbstractBackground and objectivesRice contains an order of magnitude higher inorganic arsenic (iAs), a class 1 non‐threshold carcinogen, than other terrestrial crops. To reduce iAs in cooked rice, several methods have been proposed such as washing until clear, cooking with high water‐to‐rice ratio (W/R) then discarding excess water, or continuously percolating near‐boiling water. The traditional method practiced by 1.6 billion East Asians, washing and cooking with low W/R until dry, removes only a small percentage of iAs. A new approach was investigated to reduce iAs in cooked rice.FindingsBrief (10 min) soaking (W/R 10) at above gelatinization temperature (80°C) reduced iAs in rice by up to 48.4%. A soaking protocol was developed for public use that on average reduced 39.5 ± 6.6% (n = 12) iAs in non‐waxy white rice.ConclusionsBrief above‐gelatinization‐temperature soaking effectively reduces iAs in cooked white rice.Significance and noveltyAbove‐gelatinization‐temperature soaking was applied for the first time to cut iAs in cooked rice; thereby chronic iAs exposure and cancer risk can be reduced for rice consumers.
Occasional human infestations by feral pigeons' ectoparasites: Two case reports
Authors: Akhoundi Mohammad , Brun Sophie , Marteau Anthony , Debédat Jean , Ben Romdhane Habib , Izri Arezki 
Published: May 2020

AbstractDermanyssus infestation is a rural parasitic problem occurs occasionally in urban areas in people with close contact to pigeons. It can be diagnosed through clinical cutaneous symptoms in exposed body parts, nocturnal itching, and presence of mites in infested locations and can be treated by antiacaricide, environmental, and symptomatic treatments.
No cognitive processing in the unconscious, anesthetic‐like, state of sleep
Authors: Vertes Robert P. , Linley Stephanie B. 
Published: May 2020

AbstractWe review evidence challenging the hypothesis that memories are processed or consolidated in sleep. We argue that the brain is in an unconscious state in sleep, akin to general anesthesia (GA), and hence is incapable of meaningful cognitive processing—the sole purview of waking consciousness. At minimum, the encoding of memories in sleep would require that waking events are faithfully transferred to and reproduced in sleep. Remarkably, however, this has never been demonstrated, as waking experiences are never truly replicated in sleep but rather appear in very altered or distorted forms. General anesthetics (GAs) exert their effects through endogenous sleep–wake control systems and accordingly GA and sleep share several common features: sensory blockade, immobility, amnesia and lack of awareness (unconsciousness). The loss of consciousness in non‐REM (NREM) sleep or to GAs is characterized by: (a) delta oscillations throughout the cortex; (b) marked reductions in neural activity (from waking) over widespread regions of the cortex, most pronounced in frontal and parietal cortices; and (c) a significant disruption of the functional connectivity of thalamocortical and corticocortical networks, particularly those involved in “higher order” cognitive functions. Several (experimental) reports in animals and humans have shown that disrupting the activity of the cortex, particularly the orbitofrontal cortex, severely impairs higher order cognitive and executive functions. The profound and widespread deactivation of the cortex in the unconscious states of NREM sleep or GA would be expected to produce an equivalent, or undoubtedly a much greater, disruptive effect on mnemonic and cognitive functions. In conclusion, we contend that the unconscious, severely altered state of the brain in NREM sleep would negate any possibility of cognitive processing in NREM sleep.
Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium
Authors: Verma Shefali Setia , Bergmeijer Thomas O. , Gong Li , Reny Jean‐Luc , Lewis Joshua P. , Mitchell Braxton D. , Alexopoulos Dimitrios , Aradi Daniel , Altman Russ B. , Bliden Kevin , Bradford Yuki , Campo Gianluca , Chang Kiyuk , Cleator John H. , Déry Jean‐Pierre , Dridi Nadia P. , Fernandez‐Cadenas Israel , Fontana Pierre , Gawaz Meinrad , Geisler Tobias , Gensini Gian Franco , Giusti Betti , Gurbel Paul A. , Hochholzer Willibald , Holmvang Lene , Kim Eun‐Young , Kim Ho‐Sook , Marcucci Rossella , Montaner Joan , Backman Joshua D. , Pakyz Ruth E. , Roden Dan M. , Schaeffeler Elke , Schwab Matthias , Shin Jae Gook , Siller‐Matula Jolanta M. , ten Berg Jurriën M. , Trenk Dietmar , Valgimigli Marco , Wallace John , Wen Ming‐Shien , Kubo Michiaki , Lee Ming Ta Michael , Whaley Ryan , Winter Stefan , Klein Teri E. , Shuldiner Alan R. , Ritchie Marylyn D. ,   for the ICPC Investigators
Published: May 2020

Antiplatelet response to clopidogrel shows wide variation, and poor response is correlated with adverse clinical outcomes. CYP2C19 loss‐of‐function alleles play an important role in this response, but account for only a small proportion of variability in response to clopidogrel. An aim of the International Clopidogrel Pharmacogenomics Consortium (ICPC) is to identify other genetic determinants of clopidogrel pharmacodynamics and clinical response. A genomewide association study (GWAS) was performed using DNA from 2,750 European ancestry individuals, using adenosine diphosphate‐induced platelet reactivity and major cardiovascular and cerebrovascular events as outcome parameters. GWAS for platelet reactivity revealed a strong signal for CYP2C19*2 (P value = 1.67e−33). After correction for CYP2C19*2 no other single‐nucleotide polymorphism reached genomewide significance. GWAS for a combined clinical end point of cardiovascular death, myocardial infarction, or stroke (5.0% event rate), or a combined end point of cardiovascular death or myocardial infarction (4.7% event rate) showed no significant results, although in coronary artery disease, percutaneous coronary intervention, and acute coronary syndrome subgroups, mutations in SCOS5P1, CDC42BPA, and CTRAC1 showed genomewide significance (lowest P values: 1.07e−09, 4.53e−08, and 2.60e−10, respectively). CYP2C19*2 is the strongest genetic determinant of on‐clopidogrel platelet reactivity. We identified three novel associations in clinical outcome subgroups, suggestive for each of these outcomes.
The role of vibrational temperature variations in a pulsed dielectric barrier discharge plasma device
Authors: do Nascimento Fellype , Moshkalev Stanislav , Machida Munemasa 
Published: May 2020

AbstractThe use of dielectric barrier discharge (DBD) plasmas has become a practical way to carry out surface treatment where precise control of the plasma parameters, such as rotational and vibrational temperatures (Trot and Tvib), is required. As the Tvib of an atmospheric pressure plasma jet appears to be the most important parameter related to the improvement of surface treatments, in this work, we analysed two methods to increase the values of Tvib in a DBD plasma jet device. One of the methods is to reduce the exit size (ø) of the DBD reactor, which results in an increase in the measured Tvib values, due to an increase in the pressure inside the reactor. The other method is to change the gas flow rate (GFR) used to produce the plasma jets. This leads to a Tvib reduction when the GFR is increased in the case of using helium or nitrogen as the working gas, but the opposite happens (an increase in the Tvib values) when argon is used, with different phenomena causing the variation of Tvib in each situation.
Erythritol‐Based Medium‐Chain Sugar Amphiphile: Synthesis and Gelling Capability in Edible Oils
Authors: Pang Min , Lei Zheng , Zheng Donglei , Shi Zhaojuan , Ge Yuanfei , Cheng Jieshun , Jiang Shaotong , Cao Lili 
Published: May 2020

AbstractThe production of organogels from vegetable oils requires low‐molecular‐weight gelators. Herein, a novel small‐molecule sugar ester gelator is synthesized from erythritol and octanoic acid. The purified reaction product is identified as erythritol 1,6‐dioctanoate by high performance liquid chromatography (HPLC) with evaporative light‐scattering detection and nuclear magnetic resonance (NMR). This low‐molecular‐weight erythritol ester exhibits self‐assembly behavior in vegetable oils with a minimum gelation concentration of 4 wt%. Microscopy reveals needle‐like crystals that became slender as the gelator concentration increases. X‐Ray Diffraction (XRD) analyses indicate that the organogels are semicrystalline with both crystalline and amorphous domains. Fourier Transform Infrared (FTIR) spectroscopy reveals that the gel structure is maintained by non‐hydrogen‐bonding interactions. Furthermore, rheological tests show that the mechanical strength of the gel is poor, but as the gelator concentration is increased, the mechanical strength and hardness of the gel also increases. Thus, this erythritol ester effectively promotes the gelation of edible vegetable oils and increases the variety of available organogelators.Practical Applications: The synthesized erythritol ester is successfully applied as a gelator to produce organogels from a variety of vegetable oils, and are expected to advance the development of effective organogelators for edible oils.
Concentration effects on capture rate and translocation configuration of nanopore‐based DNA detection
Authors: Zhang Yin , Zhao Jiabin , Kan Yajing , Ji Rui , Pan Jianqiang , Huang Weichi , Xu Zheng , Si Wei , Sha Jingjie 
Published: May 2020

AbstractNanopore is a kind of powerful tool to detect single molecules and investigate fundamental biological processes. In biological cells or real detection systems, concentration of DNA molecules is various. Here, we report an experimental study of the effects of DNA concentration on capture rate and translocation configuration with different sized nanopores and applied voltages. Three classes of DNA translocation configurations have been observed including linear translocation, folded translocation, and cotranslocation. In the case of relatively large sized nanopore or high applied voltage, considerable cotranslocation events have been detected. The percentage of cotranslocation events also increases with DNA concentration, which leads to the relationship between capture rate and DNA concentration deviates from linearity. Therefore, in order to reflect the number of translocation molecules accurately, the capture rate should be corrected by double‐counting cotranslocation events. These results will provide a valuable reference for the design of nanopore sensors.