bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-driven modelling and spatial complexity supports heterogeneity-based integrative management for eliminating Simulium neavei-transmitted river blindness
Authors: Michael Edwin , Smith Morgan E. , Singh Brajendra K. , Katabarwa Moses N. , Byamukama Edson , Habomugisha Peace , Lakwo Thomson , Tukahebwa Edridah , Richards Frank O. 
Published: March 2020

AbstractConcern is emerging regarding the challenges posed by spatial complexity for modelling and managing the area-wide elimination of parasitic infections. While this has led to calls for applying heterogeneity-based approaches for addressing this complexity, questions related to spatial scale, the discovery of locally-relevant models, and its interaction with options for interrupting parasite transmission remain to be resolved. We used a data-driven modelling framework applied to infection data gathered from different monitoring sites to investigate these questions in the context of understanding the transmission dynamics and efforts to eliminateSimulium neavei- transmitted onchocerciasis, a macroparasitic disease that causes river blindness in Western Uganda and other regions of Africa. We demonstrate that our Bayesian-based data-model assimilation technique is able to discover onchocerciasis models that reflect local transmission conditions reliably. Key management variables such as infection breakpoints and required durations of drug interventions for achieving elimination varied spatially due to site-specific parameter constraining; however, this spatial effect was found to operate at the larger focus level, although intriguingly including vector control overcame this variability. These results show that data-driven modelling based on spatial datasets and model-data fusing methodologies will be critical to identifying both the scale-dependent models and heterogeneity-based options required for supporting the successful elimination ofS. neavei-borne onchocerciasis.
Characteristics and associated factors of physical activity-related injuries among university students in southern China
Authors: Cai Weicong , Tang Dongchun , Gao Yang , Yang Wenda , Chen Shangmin , Gao Lijie , Jia Cunxian , Li Liping 
Published: March 2020

AbstractThis cross-sectional study aimed to describe the characteristics of physical activity-related injury (PARI) and to explore its associated factors among university students in Chaoshan district. Selected from the baseline survey in March and April, 434 students graded 1–3 from two universities were interviewed face-to-face in April and May 2017. Socio-demographics, physical activity (PA) participation, risk-taking behaviors, and PARI occurrences in the past 12 months were collected. Group Lasso logistic regression was applied to identify the risk factors of PARI. Totally, 317 PARI episodes were reported by 184 subjects with an overall injury risk of 0.73 injuries/student/year (males: 1.00, females: 0.63) and an injury incidence density of 0.81 injuries per 1000 PA exposure hours (males: 1.13, females: 0.69). Most injuries involved the lower extremities and were sprains and strains. Males, sports team members, and those with high-risk rebellious and anti-social behaviors were more likely to sustain PARI compared to their counterparts. Those who participated in vigorous-intensity PA with longer duration (particularly ≥ 150 min/week) were at a higher risk for PARI. This study indicates that PARI is a health concern among university students and great efforts should be taken to prevent them from PARI when promoting a physically active lifestyle.
Evolutionary and Molecular Characterization of liver-enriched gene 1
Authors: Dang Yanna , Wang Jin-Yang , Liu Chen , Zhang Kun , Jinrong Peng , He Jin 
Published: March 2020

AbstractLiver-enriched gene 1 (Leg1) is a newly identified gene with little available functional information. To evolutionarily and molecularly characterize Leg1 genes, a phylogenetic study was first conducted, which indicated that Leg1 is a conserved gene that exists from bacteria to mammals. During the evolution of mammals, Leg1s underwent tandem duplications, which gave rise to Leg1a, Leg1b, and Leg1c clades. Analysis of the pig genome showed the presence of all three paralogs of pig Leg1 genes (pLeg1s), whereas only Leg1a could be found in the human (hLeg1a) or mouse (mLeg1a) genomes. Purifying force acts on the evolution of Leg1 genes, likely subjecting them to functional constraint. Molecularly, pLeg1a and its coded protein, pig LEG1a (pLEG1a), displayed high similarities to its human and mouse homologs in terms of gene organization, expression patterns, and structures. Hence, pLeg1a, hLeg1a, and mLeg1a might preserve similar functions. Additionally, expression analysis of the three Leg1as suggested that eutherian Leg1as might have different functions from those of zebrafish and platypus due to subfunctionalization. Therefore, pLeg1a might provide essential information about eutherian Leg1a. Moreover, a preliminary functional study using RNA-seq suggested that pLeg1a is involved in the lipid homeostasis. In conclusion, our study provides some basic information on the aspects of evolution and molecular function, which could be applied for further validation of Leg1 using pig models.
Fluctuations of the elemental composition in the layers of mineral deposits formed on the elements of biogas engines
Authors: Stanuch Ireneusz , Sozańska Maria , Biegańska Jolanta , Cebula Jan , Nowak Jacek 
Published: March 2020

AbstractThe aim of the research was to compare the chemical composition and morphology of the surface of the backsheet growing on the metallic and surface substrate growing already on the prepared mineral substrate. Moreover the aim of this study was also to analyze the dispersion of chemical elements on the cross-sections of deposits formed on parts of landfill biogas-driven engines. The chemical composition of extreme layers of mineral deposits extracted from the engine piston and their cross-sections from four pistons and one head was examined by SEM-EDS. The bottom side showed a much smaller heterogeneity of the topography of the surface than the topside. The chemical composition of the deposit bottom side it primarily S (41%), Si (34%) and Al (17%). In the case of the top side, the dominated of Ca (52%) with a relatively high share of S (32%) and Si (14%). The presence of P and Mg it was also found, but only on the bottom side, and the share of Fe and Zn only on the top side. In the case of cross-sections, Ca, S and Si were the dominant elements. In general, there were higher Si participations in the zone of the bottom layer with a downward trend to the top sheet. The mass shares of S and Ca were lower in the zone of the bottom layer with the upward trend to the top sheet, also undergoing fluctuation.
3-D magnetohydrodynamic AA7072-AA7075/methanol hybrid nanofluid flow above an uneven thickness surface with slip effect
Authors: Tlili Iskander , Nabwey Hossam A. , Ashwinkumar G. P. , Sandeep N. 
Published: March 2020

AbstractA 3-D magnetohydrodynamic flow of hybrid nanofluid across a stretched plane of non-uniform thickness with slip effects is studied. We pondered aluminum alloys of AA7072 and AA7072 + AA7075 in methanol liquid. The aluminum alloys amalgamated in this study are uniquely manufactured materials, possessing enhanced heat transfer features. AA7072 alloy is a composite mixture of Aluminum & Zinc in the ratio 98 & 1 respectively with added metals Silicon, ferrous and Copper. Equally, AA7075 is a mixture of Aluminum, Zinc, Magnesium, and Copper in the ratio of ~90, ~6, ~3 and ~1 respectively with added metals Silicon ferrous and Magnesium. Numerical solutions are attained using R-K based shooting scheme. Role of physical factors on the flow phenomenon are analyzed and reflected by plots and numerical interpretations. Results ascertain that heat transfer rate of the hybrid nanoliquid is considerably large as matched by the nanofluid. The impact of Lorentz force is less on hybrid nanofluid when equated with nanofluid. Also, the wall thickness parameter tends to improve the Nusselt number of both the solutions.
Patient- and 3D morphometry-based nose outcomes after skeletofacial reconstruction
Authors: Denadai Rafael , Chou Pang-Yun , Seo Hyung Joon , Lonic Daniel , Lin Hsiu-Hsia , Pai Betty C. J. , Lo Lun-Jou 
Published: March 2020

AbstractPatient satisfaction with the shape and appearance of their nose after orthognathic surgery-based skeletofacial reconstruction is an important, but often overlooked, outcome. We assessed the nose-related outcomes through a recently developed patient-reported outcome instrument and a widely adopted 3D computer-based objective outcome instrument, to verify any correlation in the results produced by these tools. We collected FACE-Q nose appearance reports (2 scales) and 3D nasal morphometry (10 parameters) from patients with class III skeletal pattern and congenital cleft lip palate deformity (n = 23) or developmental dentofacial deformity (n = 23) after (>12 months) skeletofacial reconstruction. The cleft and dentofacial cohorts demonstrated significantly (p < 0.001) poorer satisfaction scores with regard to the FACE-Q nostrils scale than the normal age-, gender-, and ethnicity-matched subjects (n = 107), without any significant difference in FACE-Q nose scale. The cleft cohort had significantly (p < 0.001) smaller nasal length, nasal tip projection, and columellar angle and greater nasal protrusion, alar width, and columellar–labial angle values than the dentofacial and normal cohorts; however, there were no significant differences between the dentofacial versus normal cohorts. The FACE-Q nose and nostrils scales were significantly (p < 0.001; r = −0.26–0.27) correlated to the results of the 3D morphometric analysis, with regard to nasal length, alar width, columella angle, and columellar–labial angle parameters. This study revealed differences in satisfaction with the appearance of the nose according to the type of underlying deformity, and demonstrated a significant correlation (low correlation coefficients) between the patient-reports and 3D image-based outcome measure tools, which has implications for multidisciplinary-centered research, auditing, and clinical care.
Effect of root interaction on nodulation and nitrogen fixation ability of alfalfa in the simulated alfalfa/triticale intercropping in pots
Authors: Zhao Yajiao , Liu Xiaojing , Tong Changchun , Wu Yong 
Published: March 2020

AbstractCereal/legume intercropping is likely to achieve the optimal exploitation of soil and atmospheric nitrogen (N) sources to maintain high production and quality levels with low N inputs, as an attempt to eliminate underlying environmental effects. Nevertheless, the extent of the effect of cereal/legume intercropping on nodulation and N fixation of intercropped legumes in root interaction requires extensive verification. In the present study, root interaction of alfalfa/triticale intercropping was simulated in pots with the use of root separation types (pot with no barrier (A-T), pot with nylon mesh barrier (NA-T), pot with plastic barrier (PA-T), and alfalfa alone (SA)) in pots. Moreover, the experiment was measured at a range of N levels (N21, N210) and growing stages (branching, budding and initial flowering stages) in growth chamber. As alfalfa was growing, the total nodule number (TNN), effective nodule number (ENN) and nitrogenase activity (NA) of alfalfa with A-T and other cropping systems more noticeably differed from each other at higher N levels, whereas their diversification was reduced at lower N levels. As alfalfa was growing continuously, fresh nodule weight per plant (PNW) and single fresh nodule weight (SNW) with A-T and other cropping systems were amplified more significantly. The nodulation and N fixation ability under N21 were more significant than those under N210. Dry weight of plant per pot (TDW) and nitrogen accumulation of plant per pot (TNA) with A-T were obviously higher than those with other systems in the initial flowering stage, except for TNA under N21. The parameters regarding the nodulation and N fixation ability were significantly positively correlated on the whole. However, SNW and TNA were not significantly correlated, neither were SNW and TDW. According to the mentioned results, the closer root interaction, the better the nodulation form and N fixation ability of alfalfa will be, and the higher the biomass and N accumulation of all plants in pots will be. Interspecific facilitation in alfalfa/triticale intercropping system resulted in a greater yield and N accumulation; it also ultimately enhanced nodulation and N fixation ability, which can be applied in sustainable systems to avoid N loss to the environment and enhance N use efficiency.
Bell’s palsy and obesity, alcohol consumption and smoking: A nested case-control study using a national health screening cohort
Authors: Kim So Young , Oh Dong Jun , Park Bumjung , Choi Hyo Geun 
Published: March 2020

AbstractThe aim of this study was to investigate the association of body mass index (BMI), alcohol consumption, and smoking status with the occurrence of Bell’s palsy. The Korean National Health Insurance Service-Health Screening Cohort of a ≥ 40-year-old population from 2000–2003 was used. A total of 5,632 Bell’s palsy participants were matched with 22,528 control participants in terms of age, sex, income, region of residence, and past medical histories of hypertension, diabetes, and dyslipidemia. Bell’s palsy was classified by a history of ≥2 diagnoses with ICD-10 code (G510) and steroid treatment. BMI (kg/m2) was classified as <18.5 (underweight), ≥18.5 to <23 (normal), ≥23 to <25 (overweight), ≥25 to <30 (obese I), and ≥30 (obese II). Alcohol consumption was divided into non-drinkers and those who drank 2–3 times a month, 1–2 times a week, and ≥3 times a week. Smoking status was categorized as current smokers, past smokers, and non-smokers. The odds of obesity, alcohol consumption, and smoking with Bell’s palsy were analyzed using logistic regression analysis. BMI showed proportionally positive associations with Bell’s palsy (adjusted OR [95% CI] = 0.61 [0.47–0.79] for underweight, 1.16 [1.08–1.26] for normal, 1.24 [1.15–1.33] for obese I, and 1.61 [1.38–1.88] for obese II, P < 0.001). The odds of alcohol consumption with Bell’s palsy were 0.90 (95% confidence interval [CI] = 0.82–0.99) for 2–3 times a month, 0.77 (95% CI = 0.69–0.85) for 1–2 times a week, and 0.79 (95% CI = 0.71–0.88) for ≥3 times a week compared to nondrinkers (P < 0.001). Smoking did not show a relationship with the occurrence of Bell’s palsy. Obesity was related to the risk of Bell’s palsy in the population over 40 years old. On the other hand, alcohol consumption was negatively associated with the occurrence of Bell’s palsy.
Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model
Authors: Schuetzenberger Kornelia , Pfister Martin , Messner Alina , Garhöfer Gerhard , Hohenadl Christine , Pfeiffenberger Ulrike , Schmetterer Leopold , Werkmeister René M. 
Published: March 2020

AbstractClinical evaluation of skin lesions requires precise and reproducible technologies for their qualitative and quantitative assessment. In this study, we investigate the applicability of a custom-built dermatologic OCT system for longitudinal assessment of intradermal volumes in a mouse model. The OCT, based on an akinetic swept laser working at 1310 nm was employed for visualization and quantification of intradermal deposits of three different hyaluronic acid-based hydrogel formulations – one commercial and two test substances. Hydrogels were applied in 22 BALB/c mice, and measurements were performed over a six-month time period. All hydrogels increased in volume within the first weeks and degraded steadily thereafter. The half-lifes of the test hydrogels (27.2 ± 13.6 weeks for Hydrogel 1, 31.5 ± 17.2 weeks for Hydrogel 2) were higher in comparison to the commercially available HA hydrogel (21.4 ± 12.0 weeks), although differences were not significant. The sphericity parameter was used for evaluation of the deposit geometry. While on the injection day the sphericities were similar (~0.75 ± 0.04), at later time points significant differences between the different test substances were found (T24: PRV 0.59 ± 0.09, Hydrogel 1 0.70 ± 0.11, Hydrogel 2 0.78 ± 0.07; p ≤ 0.012 for all pairs). This study shows the applicability of OCT imaging for quantitative assessment of the volumetric behavior of intradermal deposits in vivo.
Full-waveform inversion imaging of the human brain
Authors: Guasch Lluís , Calderón Agudo Oscar , Tang Meng-Xing , Nachev Parashkev , Warner Michael 
Published: March 2020

AbstractMagnetic resonance imaging and X-ray computed tomography provide the two principal methods available for imaging the brain at high spatial resolution, but these methods are not easily portable and cannot be applied safely to all patients. Ultrasound imaging is portable and universally safe, but existing modalities cannot image usefully inside the adult human skull. We use in silico simulations to demonstrate that full-waveform inversion, a computational technique originally developed in geophysics, is able to generate accurate three-dimensional images of the brain with sub-millimetre resolution. This approach overcomes the familiar problems of conventional ultrasound neuroimaging by using the following: transcranial ultrasound that is not obscured by strong reflections from the skull, low frequencies that are readily transmitted with good signal-to-noise ratio, an accurate wave equation that properly accounts for the physics of wave propagation, and adaptive waveform inversion that is able to create an accurate model of the skull that then compensates properly for wavefront distortion. Laboratory ultrasound data, using ex vivo human skulls and in vivo transcranial signals, demonstrate that our computational experiments mimic the penetration and signal-to-noise ratios expected in clinical applications. This form of non-invasive neuroimaging has the potential for the rapid diagnosis of stroke and head trauma, and for the provision of routine monitoring of a wide range of neurological conditions.
Two-dimensional amine and hydroxy functionalized fused aromatic covalent organic framework
Authors: Mahmood Javeed , Ahmad Ishfaq , Jung Minbok , Seo Jeong-Min , Yu Soo-Young , Noh Hyuk-Jun , Kim Young Hyun , Shin Hyung-Joon , Baek Jong-Beom 
Published: March 2020

AbstractOrdered two-dimensional covalent organic frameworks (COFs) have generally been synthesized using reversible reactions. It has been difficult to synthesize a similar degree of ordered COFs using irreversible reactions. Developing COFs with a fused aromatic ring system via an irreversible reaction is highly desirable but has remained a significant challenge. Here we demonstrate a COF that can be synthesized from organic building blocks via irreversible condensation (aromatization). The as-synthesized robust fused aromatic COF (F-COF) exhibits high crystallinity. Its lattice structure is characterized by scanning tunneling microscopy and X-ray diffraction pattern. Because of its fused aromatic ring system, the F-COF structure possesses high physiochemical stability, due to the absence of hydrolysable weak covalent bonds.
Regionale Pflichtversorgung in der stationären Psychiatrie und Psychotherapie
Authors: Ziereis Michael , Günther Stefan , Baghai Thomas C. , Rupprecht Rainer 
Published: March 2020

ZUSAMMENFASSUNG
Gegenstand und Ziel Die vorliegende Studie zeigt einen alternativen Weg zur Operationalisierung des Begriffs „regionale Pflichtversorgung“ in der stationären Psychiatrie und Psychotherapie auf.
Material und Methoden In einer explorativen Analyse von 9659 Behandlungsfällen von psychiatrischen Fachabteilungen an 3 Standorten wurden aus Routinedaten gewonnene Kennzahlen hinsichtlich ihrer Eignung zur Abbildung des Begriffs untersucht.
Ergebnisse Im Abgleich mit einem Expertenrating konnten hohe Übereinstimmungswerte vor allem bei denjenigen Parametern gefunden werden, die den Aspekt der Vollversorgung („Diagnosespektrum“), der Notfallversorgung („Aufnahmezeit“) und den Aspekt der Versorgungsleistung in der Region („Hauptversorgungsgebiet“) abbilden.
Schlussfolgerung Als Vorteile der Methodik werden die aufwandsneutrale Erhebungs- und Überprüfungsmechanismen sowie die vergleichsweise hohe Objektivität und Reliabilität der generierten Kennzahlen gesehen. Zudem eröffnet dieses Vorgehen die Perspektive einer Generalisierbarkeit des Begriffs der Pflichtversorgung auf andere Fachabteilungen ohne die psychiatriespezifische Besonderheit der gerichtlichen Unterbringung. Aufgrund der geringen Anzahl der betrachteten Standorte bedarf es jedoch zwingend weiterer konfirmatorischer, multizentrischer Untersuchungen.
Klinische Relevanz Ziel kann dabei die Generierung eines Komplexindex sein, welcher eine valide Abbildung des Konstrukts „regionale Pflichtversorgung“ erlaubt und damit die Basis für eine adäquate und leistungsgerechte Ressourcenzuweisung an die Kliniken vor dem Hintergrund der gesundheitspolitischen Bestrebungen für eine Neuordnung der Personalbemessung in den entsprechenden Fachgebieten schafft.
Wirksamkeit von Disease-Management-Programmen für Asthma und COPD? Ergebnisse einer Querschnittstudie
Authors: Kanniess F. , Krockenberger K. , Oepen P. , Hedrich R. , Olbrich D. , Hessler N. , Ziegler A. , Langer-Brauburger B. 
Published: March 2020

Zusammenfassung
Einleitung Die Wirksamkeit der deutschen Disease-Management-Programme (DMP) Asthma und chronisch obstruktive Lungenerkrankung (COPD) kann mit den gesetzlich vorgeschriebenen Dokumentationen nicht gezeigt werden. Studien mit Vergleichsgruppen sind selten. Ziel war es, in einer Querschnittstudie zu untersuchen, ob sich die Krankheitskontrolle bei Teilnehmern (DMP+) und Nicht-Teilnehmern (DMP–) der DMP Asthma und COPD voneinander unterscheidet.
Methoden Die Studie ist eine prospektive, multizentrische Querschnittstudie, die untersucht, inwieweit DMP+-Patienten sich von entsprechenden DMP–-Patienten im Hinblick auf ihre Krankheitskontrolle voneinander unterscheiden. Primärer Endpunkt war die Krankheitskontrolle, gemessen mit dem Asthma-Control-Test™ (ACT) im Studienteil Asthma sowie dem COPD-Assessment-Test™ (CAT) im Studienteil COPD.
Ergebnisse Insgesamt wurden 1038 Asthma-Patienten und 846 COPD-Patienten eingeschlossen, je mit etwa 70 % DMP-Teilnehmern. Der ACT-Score war bei den Asthma-DMP+-Patienten höher als bei den DMP– -Patienten (Mittelwertdifferenz 0,86; 95 % KI: 0,29 – 1,43; p = 0,003), allerdings klinisch nicht relevant. Bei COPD-Patienten fand sich ebenfalls kein klinisch relevanter Unterschied in der Krankheitskontrolle (0,52; 95 % KI: – 0,71 – 1,75; p = 0,405). Nur etwa 60 % der Patienten, die seit mindestens einem Jahr in das entsprechende DMP eingeschrieben waren, hatten an einer strukturierten Schulung teilgenommen. Zwischen geschulten und nicht geschulten Patienten fand sich kein Unterschied in der Krankheitskontrolle.
Diskussion Es fand sich kein klinisch relevanter Unterschied in der Krankheitskontrolle zwischen DMP+ - und DMP– -Patienten für die DMP Asthma und COPD. International wurde die Wirksamkeit von DMP bei Asthma und COPD in randomisierten Studien nachgewiesen. Auch in Deutschland sollten randomisierte Studien durchgeführt werden, um die Wirksamkeit der DMP Asthma und COPD zu belegen.
Registrierung drks.de, DRKS00007664, Registrierungsdatum: 15.01.2015