bluuebunny/crossref_metadata_2025_split huggingface dataset:
Above‐ and below‐ground assessment of carabid community responses to crop type and tillage
Authors: Jowett Kelly , Milne Alice E. , Garrett Dion , Potts Simon G. , Senapathi Deepa , Storkey Jonathan 
Published: July 2020

AbstractCarabid beetles are major predators in agro‐ecosystems. The composition of their communities within crop environments governs the pest control services they provide. An understudied aspect is the distribution of predacious carabid larvae in the soil.We used novel subterranean trapping with standard pitfall trapping, within a multi‐crop rotation experiment, to assess the responses of above‐ and below‐ground carabid communities to management practices.Crop and trap type significantly affected pooled carabid abundance with an interaction of the two, the highest numbers of carabids were caught in subterranean traps in barley under sown with grass.Trap type accounted for the most variance observed in carabid community composition, followed by crop.Tillage responses were only apparent at the species level for three of the eight species modelled.Responses to crop type varied by species. Most species had higher abundance in under‐sown barley, than grass, wheat and barley. Crop differences were greater in the subterranean trap data. For predaceous larvae, standard pitfalls showed lowest abundances in under‐sown barley, yet subterranean traps revealed abundances to be highest in this crop.Comprehensive estimation of ecosystem services should incorporate both above‐ and below‐ground community appraisal, to inform appropriate management.
Antihypertensive activity and molecular interactions of irbesartan in complex with 2‐hydroxypropyl‐β‐cyclodextrin
Authors: Leonis Georgios , Christodoulou Eirini , Ntountaniotis Dimitrios , Chatziathanasiadou Maria V. , Mavromoustakos Thomas , Naziris Nikolaos , Chountoulesi Maria , Demetzos Costas , Valsami Georgia , Damalas Dimitrios E. , Tzakos Andreas G. , Thomaidis Nikolaos S. , Karageorgos Vlasios , Liapakis Georgios 
Published: July 2020

AbstractIrbesartan (IRB) exerts beneficial effects either alone or in combination with other drugs on numerous diseases, such as cancer, diabetes, and hypertension. However, due to its high lipophilicity, IRB does not possess the optimum pharmacological efficiency. To circumvent this problem, a drug delivery system with 2‐hydroxypropyl‐β‐cyclodextrin (2‐HP‐β‐CD) was explored. The 1:1 complex between IRB and 2‐HP‐β‐CD was identified through ESI QTF HRMS. Dissolution studies showed a higher dissolution rate of the lyophilized IRB–2‐HP‐β‐CD complex than the tablet containing IRB at pH = 1.2. DSC results revealed the differences of the thermal properties between the complex and various mixtures consisting of the two components, namely IRB and 2‐HP‐β‐CD. Interestingly, depending on the way the mixture preparation was conducted, different association between the two components was observed. Molecular dynamics (MD) simulations predicted the favorable formation of the above complex and identified the dominant interactions between IRB and 2‐HP‐β‐CD.In vitropharmacological results verified that the inclusion complex not only preserves the binding affinity of IRB for AT1R receptor, but also it slightly increases it. As the complex formulation lacks the problems of the tablet, our approach is a promising new way to improve the efficiency of IRB.
A new house dust mite–driven and mast cell–activated model of asthma in the guinea pig
Authors: Ramos‐Ramírez Patricia , Noreby Malin , Liu Jielu , Ji Jie , Abdillahi Suado M. , Olsson Henric , Dahlén Sven‐Erik , Nilsson Gunnar , Adner Mikael 
Published: July 2020

AbstractBackgroundAnimal models are extensively used to study underlying mechanisms in asthma. Guinea pigs share anatomical, pharmacological and physiological features with human airways and may enable the development of a pre‐clinical in vivo model that closely resembles asthma.ObjectivesTo develop an asthma model in guinea pigs using the allergen house dust mite (HDM).MethodsGuinea pigs were intranasally sensitized to HDM which was followed by HDM challenges once weekly for five weeks. Antigen‐induced bronchoconstriction (AIB) was evaluated as alterations in Rn (Newtonian resistance), G (tissue damping) and H (tissue elastance) at the first challenge with forced oscillation technique (FOT), and changes in respiratory pattern upon each HDM challenge were assessed as enhanced pause (Penh) using whole‐body plethysmography. Airway responsiveness to methacholine was measured one day after the last challenge by FOT. Inflammatory cells and cytokines were quantified in bronchoalveolar lavage fluid, and HDM‐specific immunoglobulins were measured in serum by ELISA. Airway pathology was evaluated by conventional histology.ResultsThe first HDM challenge after the sensitization generated a marked increase in Rn and G, which was abolished by pharmacological inhibition of histamine, leukotrienes and prostanoids. Repeated weekly challenges of HDM caused increase of Penh and a marked increase in airway hyperresponsiveness for all three lung parameters (Rn, G and H) and eosinophilia. Levels of IgE, IgG1, IgG2 and IL‐13 were elevated in HDM‐treated guinea pigs. HDM exposure induced infiltration of inflammatory cells into the airways with a pronounced increase of mast cells. Subepithelial collagen deposition, airway wall thickness and goblet cell hyperplasia were induced by repeated HDM challenge.Conclusion and Clinical RelevanceRepeated intranasal HDM administration induces mast cell activation and hyperplasia together with an asthma‐like pathophysiology in guinea pigs. This model may be suitable for mechanistic investigations of asthma, including evaluation of the role of mast cells.
Corrigendum of Zhao et al. (2020): a revised infrageneric classification of Lepisorus (Polypodiaceae)
Authors: Zhao Cun‐Feng , Wei Ran , Zhang Xian‐Chun 
Published: July 2020

AbstractHere, we publish Lepisorus sect. Paragramma (Blume) C.F. Zhao, R. Wei & X.C. Zhang as a combinatio nova to replace the section name in Zhao et al. (2020), which was published as a status nova and turned out to be an invalid name, because we cited an incorrect basionym. A revised infrageneric classification of Lepisorus also is proposed.
Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone contact allergy: A 24‐year, single‐center, retrospective cohort study from Turkey
Authors: Özkaya Esen , Kılıç Sayar Sıla , Babuna Kobaner Goncagül , Pehlivan Gizem 
Published: July 2020

AbstractBackgroundMethylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI allergy caused a global epidemic during the period 2010 to 2015, reaching its peak in 2013/14.ObjectiveTo investigate the characteristics of MCI/MI and MI allergy in Turkey over 24 years.MethodsA total of 2310 patients patch tested between 1996 and 2019 with MCI/MI 0.01% aq. or MCI/MI 0.02% aq., with or without MI 0.2% aq., were analyzed.ResultsThe overall prevalence of contact sensitization was 3.3% (n = 77) with a peak level of 16.4% in 2015. The prevalence gradually decreased thereafter, but was still high (6.5%) in 2019. Seventy‐three patients had clinically relevant sensitizations. MI could detect clinically relevant sensitizations in all seven patients with a negative patch test reaction to MCI/MI 0.02%. Non‐occupational allergic contact dermatitis (ACD) was most frequently seen, mainly in women, with hand/face eczema from rinse‐off or leave‐on cosmetics, such as wet wipes. Occupational ACD was mainly seen among men with airborne eczema from wall paints in house painters, or with hand eczema from hair gel/wax in men's barbers.ConclusionsThe prevalence of MCI/MI and MI sensitization in Turkey following the peak in 2015 is still high. This is probably due to the currently allowed level of 100 ppm for MI in rinse‐off cosmetics. This needs to be urgently reduced.
Diagnostic accuracy of Augurix COVID‐19 IgG serology rapid test
Authors: Andrey Diego O. , Cohen Patrick , Meyer Benjamin , Torriani Giulia , Yerly Sabine , Mazza Lena , Calame Adrien , Arm‐Vernez Isabelle , Guessous Idris , Stringhini Silvia , Roux‐Lombard Pascale , Fontao Lionel , Agoritsas Thomas , Stirnemann Jerôme , Reny Jean‐Luc , Siegrist Claire‐Anne , Eckerle Isabella , Kaiser Laurent , Vuilleumier Nicolas ,   for the Geneva Centre for Emerging Viral Diseases
Published: July 2020

AbstractAimsTo validate the diagnostic accuracy of the Augurix SARS‐CoV‐2 IgM/IgG rapid immunoassay diagnostic test (RDT) for COVID‐19.MethodsIn this unmatched 1:1 case‐control study, blood samples from 46 real‐time RT‐PCR–confirmed SARS‐CoV‐2 hospitalized cases and 45 healthy donors (negative controls) were studied. Diagnostic accuracy of the IgG RDT was assessed against both an in‐house recombinant spike‐expressing immunofluorescence assay (rIFA), as an established reference method (primary endpoint), and the Euroimmun SARS‐CoV‐2 IgG enzyme‐linked immunosorbent assays (ELISA) (secondary endpoint).ResultsCOVID‐19 patients were more likely to be male (61% vs 20%; P = .0001) and older (median 66 vs 47 years old; P < .001) than controls. Whole blood IgG‐RDT results showed 86% and 93% overall Kendall concordance with rIFA and IgG ELISA, respectively. IgG RDT performances were similar between plasma and whole blood. Overall, RDT sensitivity was 88% (95% confidence interval [95%CI]: 70‐96), specificity 98% (95%CI: 90‐100), PPV 97% (95%CI: 80‐100) and NPV 94% (95%CI: 84‐98). The IgG‐RDT carried out from 0 to 6 days, 7 to 14 days and > 14 days after the SARS‐CoV‐2 RT‐PCR test displayed 30%, 73% and 100% positivity rates in the COVID‐19 group, respectively. When considering samples taken >14 days after RT‐PCR diagnosis, NPV was 100% (95%CI:90‐100), and PPV was 100% (95%CI:72‐100).ConclusionsThe Augurix IgG‐RDT done in whole blood displays a high diagnostic accuracy for SARS‐CoV‐2 IgG in high COVID‐19 prevalence settings, where its use could be considered in the absence of routine diagnostic serology facilities.
The McGill‐Mouse‐Miniscope platform: A standardized approach for high‐throughput imaging of neuronal dynamics during behavior
Authors: Mosser Coralie‐Anne , Haqqee Zeeshan , Nieto‐Posadas Andrés , Murai Keith K. , Stifani Stefano , Williams Sylvain , Brandon Mark P. 
Published: July 2020

AbstractUnderstanding the rules that govern neuronal dynamics throughout the brain to subserve behavior and cognition remains one of the biggest challenges in neuroscience research. Recent technical advances enable the recording of increasingly larger neuronal populations to produce increasingly more sophisticated datasets. Despite bold and important open‐science and data‐sharing policies, these datasets tend to include unique data acquisition methods, behaviors, and file structures. Discrepancies between experimental protocols present key challenges in comparing data between laboratories and across different brain regions and species. Here, we discuss our recent efforts to create a standardized and high‐throughput research platform to address these issues. The McGill‐Mouse‐Miniscope (M3) platform is an initiative to combine miniscope calcium imaging with standardized touchscreen‐based animal behavioral testing. The goal is to curate an open‐source and standardized framework for acquiring, analyzing, and accessing high‐quality data of the neuronal dynamics that underly cognition throughout the brain in mice, marmosets, and models of disease. We end with a discussion of future developments and a call for users to adopt this standardized approach.
How to keep up to date with medical information using web‐based resources: a systematised review and narrative synthesis
Authors: Bougioukas Konstantinos I. , Bouras Emmanouil C. , Avgerinos Konstantinos I. , Dardavessis Theodore , Haidich Anna‐Bettina 
Published: July 2020

AbstractBackgroundKeeping up to date with the latest medical information using Web‐based resources has been sparsely described, and a comprehensive up‐to‐date review is needed.ObjectivesTo summarise the Web‐based ‘channels’ that may assist the actors of the health care system (clinicians, medical researchers and students) to keep up to date with medical information.MethodsWe searched PubMed and Scopus for English language articles published between January 1990 and February 2019 that investigated ways for keeping up with medical information. We used the results from our search and relevant information from other sources to conduct a narrative synthesis.ResultsWe found that resources that push information (e.g. web alerts, medical newsletters, listservs), resources that rely on the active information seeking (e.g. access to health librarians and electronic databases, podcasts, mobile apps), collaborative resources (e.g. web conferences, online journal clubs, web social media) and resources that synthesise information (e.g. bibliometrics, living systematic reviews) can contribute in keeping up with new findings and can enhance evidence‐based medicine. Clinicians, medical researchers and students can benefit from the proper use of such Internet‐based technological innovations.ConclusionInternet provides many resources that can help the actors of the health care system stay up to date with the latest scientific findings.
Electricity awareness and consumer demand for information
Authors: Trotta Gianluca 
Published: July 2020

AbstractWith the envisioned growth in the residential electricity demand and increased share of intermittent renewables in the supply mix, consumers will need to be better informed about their electricity consumption and to play an active role in managing their electricity use. However, consumer inattention and lack of information are ubiquitous, especially in household energy‐related settings. Thus, using a novel survey and actual monthly electricity consumption data, this study set out to measure the level of awareness about electricity bills, prices and costs among some Finnish households—as captured by the answers to six questions—and to investigate whether higher levels of “electricity awareness” are associated with electricity savings. In addition, this study analyses the willingness to receive extra information about energy consumption and savings and how it differs between “electricity aware” and “electricity unaware” respondents. The results indicate low levels of “electricity awareness” among the respondents of the survey. Compared to the respondents with little knowledge about electricity bills, prices and costs, the respondents with higher levels of “electricity awareness” tend to consume less electricity. Higher levels of awareness about electricity use and consumption might “materialize” inconspicuous consumption patterns, as opposed to more general facts about the largely invisible environmental consequences of everyday practices. More than two‐thirds of the total number of respondents would like to receive additional information about energy consumption and how to save energy. However, there exists a significant portion of “electricity unaware” respondents who are not only unwilling to receive such information, but are also unaware of their own knowledge deficits. To maximize the impact of any information strategy, decision makers should attempt to engage with this type of consumer; by becoming more aware of their knowledge deficits, people might become more receptive to information that can benefit them.
Share repurchases and market signaling: Evidence from earnings management
Authors: Chen Ni‐Yun , Liu Chi‐Chun 
Published: July 2020

AbstractFirms may repurchase shares to send true or false signals to the market. Since the mindset of managers is invisible, we measure it with earnings management. Discretionary accruals are used to proxy for earnings management. We show that earnings management is negatively related to the probability and frequency of share repurchase announcements. We also show that earnings management is negatively related to postannouncement 2‐year operating performance and stock returns. Our findings support the prediction that the magnitude of earnings management can serve as a reliable indicator of managers' mindsets with regard to the valuation of firms.
Is an M&A self‐dealing? Evidence on international and domestic acquisitions and CEO compensation
Authors: Choi Jongmoo Jay , Genc Omer F. , Ju Ming 
Published: July 2020

AbstractWe examine the effect of international acquisitions on CEO compensation for US firms from 1995 to 2016 using both domestic acquisition and no acquisition firms as benchmarks. We find that acquisitions lead to a greater increase in CEO compensation (especially incentive‐based compensation), which is consistent with agency theory and inconsistent with stewardship or reputation theory. We also find that international acquisitions lead to a greater increase in CEO incentive‐based compensation than domestic acquisitions, supporting matching theory given that international acquisitions are larger and more complex to manage. Additionally, we document that CEO tenure has a positive effect on CEO compensation, whereas firm relatedness has a negative effect on post‐acquisition CEO compensation. This is the first study of its type based on comprehensive data, and it contributes to our understanding of the role of international and domestic acquisitions in CEO compensation.
Buccal bone thickness of maxillary anterior teeth: A systematic review and meta‐analysis
Authors: Tsigarida Alexandra , Toscano Jeremy , de Brito Bezerra Beatriz , Geminiani Alessandro , Barmak Abdul B. , Caton Jack , Papaspyridakos Panos , Chochlidakis Konstantinos 
Published: July 2020

AbstractAimTo systematically review buccal bone thickness (BBT) in the anterior maxilla in different teeth, age groups and genders.Materials and MethodsPubMed, EMBASE and Cochrane databases were searched up to April 2020. Clinical and radiographic studies reporting on BBT of maxillary anterior teeth, with at least 10 patients, were included. A meta‐analysis was performed using random effect models to report differences of BBT.Results50 studies were included. Using bone crest (BC) as a reference point, no significant differences were found in BBT between different tooth types, except for 0.16 mm (95%‐CI: 0.02–0.30) increased mid‐root thickness of premolars compared to canines. Using the CEJ as a reference point, canines presented with a significantly increased thickness of 0.32 mm (95%‐CI: 0.11–0.54) coronally compared to laterals. When BC was used as reference, males demonstrated a significantly increased thickness of 0.21 mm (95%‐CI: 0.15–0.27) apically, while middle‐aged adults showed a 0.06 mm (95%‐CI: −0.12, −0.01) statistically significant increase in the coronal level compared to older adults.ConclusionsFew maxillary anterior teeth have BBT greater than 1 mm. Buccal bone tends to get thicker from a coronal to apical position along the root surface and from an anterior to posterior position in the arch.
Modeling of drying and rehydration kinetics ofRosa pimpinellifoliafruits: Toward formulation and optimization of a new tea with high antioxidant properties
Authors: Pashazadeh Hojjat , Zannou Oscar , Koca Ilkay 
Published: July 2020

AbstractRosa pimpinellifoliais the black of rosehips having many uses in the food and pharmaceutical industries. The modeling of drying and rehydration kinetics of the fruits as well as the optimization of preparation conditions of a new tea was investigated. Empirical models were applied to predict the drying and rehydration behaviors ofR. pimpinellifoliafruits. Response surface methodology was used to optimize the tea preparation together with antioxidant properties. The analysis of drying behavior of the fruits revealed that they dried faster at higher temperatures (70–90°C/1.75 m/s); however, the antioxidant properties were most preserved at 70°C. Midilli model was the best‐fitted model describing the drying kinetic of the fruits. The rehydration capacity was more effective at 60°C compared to 20 and 40°C. Peleg, Vega‐Gálvez, and Weibull models depicted better the rehydration behavior of these fruits. The teas were prepared with the fruits dried that 70°C/1.75 m/s since they displayed the highest antioxidant properties. The optimum conditions were 15 min decoction time and 1.5 g solid‐to‐liquid ratio. Higher antioxidant properties were observed inR. pimpinellifoliatea when compared to fresh and dried fruit. These findings showed thatR. pimpinellifoliafruits are valuables as an industrial product.Practical ApplicationsThe drying conditions to have a dried fruit with high antioxidant properties were determined. The dried food is afforded in off‐seasons. Mathematical models were successfully applied to describe the drying and rehydration kinetics ofR. pimpinellifolia. Midilli model was the most fitted model to predict the drying kinetics ofR. pimpinellifolia. Peleg, Vega‐Gálvez, and Weibull models depicted better the rehydration kinetics ofR. pimpinellifoliaat 20, 40, and 60°C. A new fruit tea was formulated from the dried fruits. This tea is a functional food having great antioxidant properties.
Shifting Cultivation in Amazonia's Middle Grounds: Propagating Connections Across Eco‐Political‐Economic Landscapes
Authors: Conklin Beth A. 
Published: July 2020

ResumoEste ensayo reflete sobre o conceito de meio‐termo e como se aplica às oportunidades e limitações criadas quando os interesses ambientais e indígenas na Amazônia se alinharam. O equilíbrio relativo de poder e as percepções de benefício mútuo que tornam possível um meio‐termo possibilitaram a alavancagem das causas nativas nos níveis nacional e internacional, mas tiveram efeitos diferentes nas comunidades onde o extrativismo e as organizações ambientais são fontes primárias de subsistência. Os estudos de caso nesta edição especial destacam as aspirações das pessoas rurais em cultivar apoio sustentado de pessoas de fora poderosas. Os desejos por dependência são antitéticos à política baseada em objetivos de independência econômica e autonomia indígena, mas contribuem para repensar a suposição de que o trabalho assalariado, e independência, e autoconfiança são objetivos universais. O desafio para os antropólogos é tornar inteligíveis os entendimentos alternativos da sociabilidade, do cuidado, e da dependência nessas conversas emergentes.
Inclusive Education Definitions and Practices: Exploring Perspectives of Education Professionals in Mexico City
Authors: Francis Grace Lavín , Lavin Carlos E. , Sanchez Jessica , Reed Alexandra S. , Mason Linda 
Published: July 2020

AbstractInclusive education (IE) is globally recognized as instrumental in facilitating equity and quality education for all students. However, despite literature documenting positive outcomes associated with IE, IE definitions and strategies vary and are not well researched in countries such as Mexico that are in the early stages of adopting IE policies. Therefore, the purpose of this study was to examine how professionals working at schools that identified themselves as “inclusive” in Mexico City, Mexico defined IE and implemented IE. Findings indicated that participants defined or described IE in several ways, including physical and educational access, socialization, personal development, equality among students, and a paradigm that requires constant reflection. Participants also described numerous IE strategies related to school culture, high expectations, administrative support, professional development, collaboration, student evaluation, accommodations and modifications, paraprofessional support, and parent involvement. Implications for practice and future research are discussed.