bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normalization based Multi-Criteria Collaborative Filtering Approach for Recommendation System
Authors: Ifada Noor , Putri Nur Fitriani Dwi , Sophan Mochammad Kautsar 
Published: January 2021

A multi-criteria collaborative filtering recommendation system allows its users to rate items based on several criteria. Users instinctively have different tendencies in rating items that some of them are quite generous while others tend to be pretty stingy. Given the diverse rating patterns, implementing a normalization technique in the system is beneficial to reveal the latent relationship within the multi-criteria rating data. This paper analyses and compares the performances of two methods that implement the normalization based multi-criteria collaborative filtering approach. The framework of the method development consists of three main processes, i.e.: multi-criteria rating representation, multi-criteria rating normalization, and rating prediction using a multi-criteria collaborative filtering approach. The developed methods are labelled based on the implemented normalization technique and multi-criteria collaborative filtering approaches, i.e., Decoupling normalization and Multi-Criteria User-based approach (DMCUser) and Decoupling normalization and Multi-Criteria User-based approach (DMCItem). Experiment results using the real-world Yelp Dataset show that DMCItem outperforms DMCUser at most in terms of Precision and Normalized Discounted Cumulative Gain (NDCG). Though DMCUser can perform better than DMCItem at large , it is still more practical to implement DMCItem rather than DMCUser in a multi-criteria recommendation system since users tend to show more interest to items at the top list.
Palliative treatment of endometrial cancer: what is the role of Anastrozole in elderly women?
Authors: Gardella Barbara , Dominoni Mattia , Bogliolo Stefano , Cassani Chiara , Carletti Giulia Vittoria , De Silvestri Annalisa , Spinillo Arsenio 
Published: January 2021

Abstract
Purpose: Type I endometrial cancer is a common disease which takes place in female genital tract. The aim of the work is to asset the feasibility and safety of anastrozole in the palliative treatment of endometrial cancer in elderly women not eligible to standard surgical treatment. Methods: eight patients with histological diagnosis of endometrial cancer were enrolled in this pilot study. Anastrozole was administered 1 mg daily per os after performing an accurate radiological mapping of the lesion. A questionnaire evaluated the quality of life of these patients. Results: the median age was 85 (range 80-88years). The endometrial cancer was confined to the uterus in all patients. No progression of disease was observed. A partial response to the therapy was reported in seven patients, while no response was reported in one patient. A decrease in the symptoms such as pain, vaginal bleeding and vaginal discomfort was reported, as well as no progression of disease. The endometrial thickness after twelve months has showed a reduction of 9.25 ± 4.77 mm. The average rate of follow-up was 18.25 months. Four women died for other reasons, none of them related to endometrial cancer. Evaluation of symptoms showed a significant reduction of appetite loss and insomnia, while a significant increase of global health status and fatigue was reported. Conclusion: our preliminary data reported that the palliative use of anastrozole may be a suitable therapy for a good control of early stages of endometrial cancer in inoperable elderly women, having a good compliance and tolerance.
Up-regulation of BRCA1 and Rad51 Genes Expression in Peripheral Blood Mononuclear Cells is Associated with Hepatitis B Patients
Authors: Asghari Arghavan , Rezae Seyed , Ziaee Masood , Valizadeh Narges , Javanmard Davod , Naseri Mohsen 
Published: January 2021

Abstract
Background: Many viruses increase their replication by affecting DNA damage response (DDR) signaling and activating and inhibiting DNA damage response factors. to date, few studies have investigated Homologous Recombination (HR) system in the field of hepatitis B patients. The current study set out to investigate HR system by examining the expression of RAD51, BRCA1, and HBx genes in peripheral blood mononuclear cells (PBMCs) of hepatitis B patients. Two groups of subjects were enrolled including healthy controls (n=61) and hepatitis B patients (n=60). The serum levels of HBV DNA, Rad5 1and BRCA1, in the PBMCs were measured using real-time quantitative polymerase chain reaction (PCR.) Moreover, serum levels of liver enzymes (ALT and AST) levels were assessed by automatic biochemical analyzer technique. Results: In HBV-infected patients, the gene expression of Rad51 and BRCA 1 were significantly upregulated compared to healthy controls (P< 0.05). However, There is a statistically significant correlation between Rad51(r= 0.838; P value < 0.001) and BRCA1(r= 0.588; P value < 0.05), genes expression and viral load. Conclusions: These results demonstrated that hepatitis B virus affected the homologous recombination system by increasing the expression of Rad51 and BRCA1 genes, suggesting these genes could be considered as valuable therapeutic targets for treating hepatitis B patients.
Surveillance culture and Gram staining for detecting the causative bacteria of ventilator-associated pneumonia in neonates
Authors: Uemura Yoshiki , Enomoto Masahiro , Sakuma Mio , Kikuchi Shin , Takei Atsuko , Ikegami Hitoshi , Minami Hirotaka , Katayama Yoshinori 
Published: January 2021

Abstract
Background

To investigate the efficacy of surveillance culture for the rapid detection of pathogens associated with ventilator-associated pneumonia (VAP) in neonates.
Methods

A retrospective study was conducted on all patients with VAP in the neonatal intensive care unit. Whether causative bacteria on the culture of tracheal aspirates obtained at the onset of VAP matched with those on Gram staining and weekly surveillance culture was investigated.
Result

The concordance rate between surveillance culture using samples collected 4–10 days before VAP and causative bacteria was 53%. When Gram staining was performed at the onset of VAP, the concordance rate significantly increased to 86% (p = 0.022).
Conclusions

The concurrent use of surveillance culture and Gram staining for the detection of causative bacteria may be effective in determining initial treatment among neonates with VAP.
Extrahepatic Alveolar Echinococcus on Multi-slice Computed Tomography and Magnetic Resonance Imaging
Authors: Hui Guo , Liu Wenya , Wang Jian , Xing Yan 
Published: January 2021

Abstract
Background. Alveolar echinococcus (AE) is a severe health problem in endemic areas. In recent years, the incidence of this disease in China has been increasing. The study was designed to illustrate the multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) features of extrahepatic AE.Methods. A cohort of 33 patients who suffered from extrahepatic AE was enrolled consecutively from January 2012 to December 2017. The MSCT and MRI features of extrahepatic AE were recorded and analyzed by experienced radiologists. The MSCT and MRI agreements for detecting imaging features of extrahepatic AE were calculated using kappa statistics.Results. All cases secondary to hepatic AE, except two primary extrahepatic AE, were found in this study. Locations of extrahepatic AE included 19 (57.6%) lung, 10 (30.3%) adrenal gland, 9 (27.3%) brain, 5 (15.2%) peritoneal cavity, 5 (15.2%) spleen, 4 (12.1%) diaphragm, 3 (9.1%) kidney, 3 (9.1%) retroperitoneal, and 2 (6.1%) vertebra; Involvement of 1 (3.0%) heart, 1 (3.0%) mediastinum, 1 (3.0%) muscle, and 1 (3.0%) pancreas was rare. AE of the lung usually appeared as irregular and scattered nodules with small vacuoles or cavities inside and peripheral distribution. Multiple cerebral nodules with calcification and surrounding edema were the most common features seen in brain AE. Adrenal gland AE presented as plaques containing different sizes of hypodense areas and different amounts of calcification. Injection of contrast medium showed no enhancement of lesions except in the brain. Very good agreements were seen between MSCT and MR for detecting number (κ=0.841, p=0.000), border (κ=0.911, p=0.000) and size (κ=0.864, p=0.000) of extrahepatic AE.Conclusions. MSCT and MRI are reliable imaging methods for the diagnosis of extrahepatic AE. When one AE patient is clinically confirmed, MSCT scan from the head to pelvis should be performed to exclude other organs AE.
Aβ Oligomers Alter NMDA Receptor Composition and Function in Early Stages of Alzheimer´s Disease
Authors: Ortiz-Sanz Carolina , Quintela-López Tania , Ruiz Asier , Balantzategi Uxue , Luchena Celia , Zuazo-Ibarra Jone , Capetillo-Zárate Estibaliz , Matute Carlos , Zugaza José L. , Alberdi Elena 
Published: January 2021

Abstract
Background Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) dysregulation may contribute to these pathological effects. Although Aβ peptides impair NMDAR expression and activity, the mechanisms mediating these alterations in early stages of AD are unclear. Here, we show that Aβ oligomers activate PKC, phosphorylate NR2B subunit and modulate its synaptic localization and function. Methods We isolated postsynaptic fractions (PSD) of AD prefrontal cortex and hippocampus of 6-month-old 3xTg-AD mice to quantify NR2B, PSD-95 and Aβ1-42 levels. To investigate the effects of Aβ oligomers on NR2B and PSD-95 expression, we use a range of techniques including mouse intrahippocampal injections of Aβ oligomers, isolation of protein membranes by cell-surface biotinylation, and synaptosomal fractionation as well as in vivo surface immunolabeling of EGFP-NR2B. Ca2+ imaging and PKC activity were monitored by fluorescent Ca2+ indicators and FRET analysis. Results We observed that NMDAR subunit NR2B and PSD-95 levels were aberrantly upregulated and correlated with Aβ42 load in human PSD fractions from early stages of AD patients as well as in hippocampus of 3xTg-AD mice. Importantly, NR2B and PSD95 dysregulation was revealed by an increased expression of both proteins in Aβ-injected mouse hippocampi. In cultured neurons, Aβ oligomers increased NR2B-containing NMDAR density and NMDA-induced synaptic Ca2+ influx in neuronal membranes in addition to colocalization in dendrites of NR2B subunit and PSD95. Mechanistically, Aβ oligomers required integrin β1 to promote synaptic location and function of NR2B-containing NMDARs and PSD95 by phosphorylation through classic PKCs. Conclusions These results provide evidence that Aβ oligomers modify the contribution of NR2B to NMDAR composition and function in early stages of AD through an integrin β1 and PKC-dependent pathway. These data reveal a novel role of Aβ oligomers in synaptic dysfunction that may be relevant to early-stage AD pathogenesis.
Lost OTR Expression and HIF-1α Self-protection in Myometrium of Intractable Postpartum Hemorrhage
Authors: Chen Yunshan , Wang Lele , Hu Minghua , Liu Feng , Deng Mingjing , Liu Huishu 
Published: January 2021

Abstract
Objective: In intractable postpartum hemorrhage(IPPH), uterotonic lost efficacy in myometrum contraction formation. While the key target in uterotonic, OTR(oxytocin receptor) and internal environment in myometrum might have some changes when IPPH. Methods: Three groups of myometrial tissue at different contraction states were collected:(1) term not at labour (TNL) group(10 cases); (2) term at labour (TAL) group(10 cases);(3) intractable postpartum hemorrhage(IPPH) group(10 cases).Expressions of OTR and internal environment markers(ASIC1a ,HIF1α, GlUT, FATP and apoptosis ) were compared in 3 groups by Immunoreactivity Scores method. Results: The expression of OTR in myometrium in IPPH group was 100% negative ,compared to 30%,20% in TNL and TAL group(p < 0.05).70% positive HIF-1α expression in TNL group increased to 80% in TAL group,but decreased to 20% in IPPH group(P<0.05). While the positive expressions of ASIC1a, FATP and GLUT in three groups all had no significant difference.But the apoptosis related markers Bax,caspase-3 and caspase-9 positive expressions in IPPH were significantly all decreased(10%,10%,0%) compared to TNL and TAL group,compared to a high positive expression of Bcl-2 in 3 groups.Conclusion: OTR expression and HIF-1α self-protection might be lost in myometrium of IPPH, which could lead to uterotonic lost efficacy and conservative treatment failure.
Numerical and Experimental Demonstration of Inverse Designed Low-index Polarization-insensitive Wavelength Demultiplexer
Authors: Icli Abdullah , Alpkilic Ahmet , Yilmaz Yusuf , Yildirim Bumin , Turduev Mirbek , Kurt Hamza 
Published: January 2021

Abstract
The computational inverse design has paved the way for the design of highly efficient, compact, and novel nanophotonic structures beyond human intuition and trial-and-error approaches. Consequently, with this new design power, the exploration and implementation of multi-objective, complex, and functional nanophotonic devices become feasible. Herein, we used a recently emerged inverse design framework to demonstrate the design of a 1 * 2 polarization-insensitive wavelength division multiplexer (PIWDM) made of a low-refractive-index material with an index of 1.55. The designed PIWDM structure successfully steers toward the targeted channels for 1.30 mm and 1.55 mm with TE and TM polarizations, respectively. The transmission values were -2.42 and -2.18 dB for TE and -2.19 and -2.23 dB for TM polarization at the upper and lower waveguides, respectively. Taking advantage of the design with a low refractive index material, we scaled the structural dimensions corresponding to the microwave region, fabricated the compact device using a 3D printer, and conducted an experiment as a proof of concept. The experimentally verified PIWDM structure shows a power transmission efficiency of over -2.42 dB and a crosstalk value of less than -11.45 dB for the targeted wavelengths.
Development and Validation an Epigenetic Modification-related Signals for Diagnosis and Prognosis of Hepatocellular Carcinoma
Authors: Wen Diguang , Qiu Sheng , Liu Zuojin 
Published: January 2021

Abstract
Background: Increasing evidence has indicated that abnormal epigenetic modification such as RNAm6a modification, histone modification, DNA methylation modification, RNA binding proteins and transcription factors, is correlated with Hepatocarcinogenesis. However, it is unknown how epigenetic modification associated genes contribute to the occurrence and clinical outcome of hepatocellular carcinoma (HCC). Thus, we constructed epigenetic modification associated model that may enhance the diagnosis and prognosis of HCC.METHODS: In this study, we focused on the clinical values of epigenetic modification associated genes for HCC. Our gene expression data were collected from TCGA and a HCC datasets from GEO dataset in order to ensure the reliability of data. Their function was analyzed by bioinformatics methods. We used lasso regression, SUV, logistic regression and cox regression to construct the diagnosis and prognosis models. We also constructed a nomogram for the practicability of the above-mentioned prognosis model. The above results have been verified in an independent liver cancer dataset from ICGC database. Furthermore, we carried out pan cancer analysis to verify the specificity of the above model.RESULT: A large number of epigenetic modification associated genes were significantly different in HCC and normal liver tissues. The gene signatures showed good performance for predicting the occurrence and survival of HCC patients verified by DCA and ROC curve.CONCLUSION: Gene signatures based on epigenetic modification associated genes can be used to identify the occurrence and prognosis of liver cancer.
Combined Deep CNN–LSTM Network-based Multitasking Learning Architecture for Noninvasive Continuous Blood Pressure Estimation using Difference in ECG-PPG Features
Authors: Jeong Da Un , Lim Ki Moo 
Published: January 2021

Abstract
The pulse transit time (PTT), which is the difference between the R-peak time of the electrocardiogram (ECG) signal and the systolic peak of the photoplethysmography (PPG) signal, is an indicator that enables noninvasive and continuous blood pressure estimation. However, it is difficult to accurately measure the PTT from the ECG and PPG signals because they have inconsistent shapes owing to patient-specific physical characteristics, pathological conditions, and movements. Accordingly, complex preprocessing is required to estimate blood pressure based on PTT. In this paper, as an alternative solution, we propose a noninvasive continuous algorithm using the difference between the ECG and PPG as a new feature that can include PTT information. The proposed algorithm is a deep CNN–LSTM-based multitasking machine learning model that outputs simultaneous prediction results of systolic (SBP) and diastolic blood pressures (DBP). The prediction accuracies of SBP and DBP using the proposed model were 0.017±1.624 mmHg and 0.164±1.297 mmHg, respectively. This result corresponded to Grade A according to the BHS and AAMI standards, which are the validation standards for blood pressure measuring devices.
Synergy Between a Shallow Root System With a DRO1&nbsp;Homologue and Localized P Application Improves Rice P Uptake&nbsp;
Authors: Oo Aung Zaw , TSUJIMOTO YASUHIRO , Mukai Mana , Nishigaki Tomohiro , Takai Toshiyuki , Uga Yusaku 
Published: January 2021

Abstract
Improved phosphorus (P) use efficiency for crop production is needed given the depleting phosphorus ore deposits and increasing ecological concerns about its excessive use. Root system architecture (RSA) is important in efficiently capturing immobile P in soils, while agronomically, localized P application near the roots is a potential approach to address this issue. However, the interaction between genetic traits of RSA and localized P application has been little understood. Near-isogenic lines (NILs) and their parent of rice (qsor1-NIL, Dro1-NIL, and IR64, with shallow, deep, and intermediate root growth angles (RGA), respectively) were grown in flooded pots after placing P near the roots at transplanting (P-dipping). The experiment identified that the P-dipping created an available P hotspot at the soil surface; the qsor1-NIL had the greatest root biomass and root surface area in the 0–3 cm soil layer despite no genotype differences in total values; the qsor1-NIL had significantly greater biomass and P uptake than the other genotypes in the P-dipping. The superior surface root development of qsor1-NIL could have facilitated P uptakes from the P hotspot, implying that P-use efficiency in crop production can be further increased by combining genetic traits of RSA and localized P application.
Evaluation of&nbsp;the Effect of the&nbsp;Capitation Compensation Mechanism among&nbsp;Tuberculosis Patients with&nbsp;a&nbsp;Full Period of Treatment
Authors: hu xingyu , gao guangying 
Published: January 2021

Abstract
Background: To explore the compensation mechanism for pulmonary tuberculosis patients with a full period of treatment, to alleviate the financial burden of pulmonary tuberculosis patients and to provide a reference and basis for the reform of tuberculosis payment methods in other regions and countries.Methods The funding operations of medical insurance institutions and the actual operating expenses of pilot hospitals from the Dehui Tuberculosis Hospital in Jilin Province were collected from the first half of 2015 to the first half of 2018, and the operational effects were analysed through quantitative and qualitative methods.Results After implementing the compensation mechanism, the medical expenses of tuberculosis patients decreased significantly, and the economic burden of the disease was reduced; the hospital's medical service capacity was improved, and internal management was significantly improved; and the medical insurance fund did not experience overspending, thus leading to a "triple win-win" situation.Conclusion The capitation compensation mechanism with a full period of treatment is a suitable payment method for TB diagnosis and treatment, and its effect is obvious, achieving a "triple win-win" for medical insurance, hospitals and patients. It is recommended to continue to promote this model to effectively reduce the financial burden of tuberculosis patients. However, in the early stage of the implementation of the plan, due to the relatively low understanding of the reform of hospitals and patients, there will be patient loss and poor compliance. Therefore, the hospital should change the management concept, incorporate the goal of payment method reform into performance management, and require all patients to be included in the treatment path to achieve standardized management of the entire treatment process. This mechanism also provides a reference for the reform of payment methods for tuberculosis in other regions or countries.
Enrichments of Ensemble Docking Strategy Based on the Bayesian Model
Authors: Lei Yu , Guo Sheng , Liu Yi , Zuo Zhili 
Published: January 2021

Abstract
MotivationChallenges remained in structure-based drug discovery which include protein flexibility in binding site. Thus, concerning the flexibility of proteins, docking into an ensemble of rigid conformations (ensemble docking) have been proposed with incorporation into protein flexibility with expects that it could provide higher enrichments than rigid single receptor. Here we have developed the ensemble docking strategy by using Bayesian Model algorithms, and this method is validated by three proteins: BTK, JAK and PARP. The Bayesian Model was used to integrate independent docking runs of an ensemble of rigid crystal structures and MD simulations. ResultsThe structure of MD simulations outperforms the crystal structures in separating inhibitors from decoys in BTK and PARP. Further, the results demonstrated that the ensemble docking strategy has better performance than rigid single conformation.
How Long is Indian Coastline?
Authors: Srivast Ravi Prakash , Dimri V. P. 
Published: January 2021

Abstract
Coastline measurements have no explicit length if they are geometrically self-similar. It is well known that length of self-similar geometrical objects is scale dependent, and hence it is not a fixed number, rather depends on the scale used to measure it. We present a definitive approach based on a fractal method to measure the coastline of India. We propose a method to define optimum scale length, that could be used to measure the coastline. Using our method, the mainland coast measures 7567 km. There are four big inhabited islands in Andaman (North, Middle, South and Little Andaman) which accounts for 687 km of island coast, and Great Nicobar Island has 195 km of coast around it, thus coastal length of inhabited islands is 882 km. Thus the total coast length of India including major 5 inhabited islands from Andaman-Nicobar group of islands is 8391 km. There are several other small islands in Andaman-Nicobar group of islands, we observed 26 of them significant in terms of their size. Indian coast length becomes 9060 km if we account for above mentioned 26 Andaman and Nicobar Islands. According to one of the Wiki articles, there are 572 islands in Andaman-Nicobar group of islands, but many of them are very small and insignificant. This is first ever scientific study about the Indian coast length, which has global significance due to strategic and climate related coastline alterations such as sea level rise due to global warming.