bluuebunny/crossref_metadata_2025_split huggingface dataset:
The breadth-depth dilemma in a finite capacity model of decision-making
Authors: Moreno-Bote Rubén , Ramírez-Ruiz Jorge , Drugowitsch Jan , Hayden Benjamin Y. 
Published: March 2020

AbstractDecision-makers are often faced with limited information about the outcomes of their choices. Current formalizations of uncertain choice, such as the explore-exploit dilemma, do not apply well to decisions in which search capacity can be allocated to each option in variable amounts. Such choices confront decision-makers with the need to tradeoff betweenbreadth- allocating a small amount of capacity to each of many options – anddepth- focusing capacity on a few options. We formalize the breadth-depth dilemma through a finite sample capacity model. We find that, if capacity is smaller than 4-7 samples, it is optimal to draw one sample per alternative, favoring breadth. However, for larger capacities, a sharp transition is observed, and it becomes best to deeply sample a very small fraction of alternatives, that decreases with the square root of capacity. Thus, ignoring most options, even when capacity is large enough to shallowly sample all of them, reflects a signature of optimal behavior. Our results also provide a rich casuistic for metareasoning in multi-alternative decisions with bounded capacity.
MutSignatures: An R Package for Extraction and Analysis of Cancer Mutational Signatures
Authors: Fantini Damiano , Vidimar Vania , Yu Yanni , Condello Salvatore , Meeks Joshua J. 
Published: March 2020

ABSTRACTCancer cells accumulate somatic mutations as result of DNA damage and inaccurate repair mechanisms. Different genetic instability processes result in distinct non-random patterns of DNA mutations, also known as mutational signatures. We developedmutSignatures, an integrated R-based computational framework aimed at deciphering DNA mutational signatures. Our software provides advanced functions for importing DNA variants, computing mutation types, and extracting mutational signatures via non-negative matrix factorization. We appliedmutSignaturesto analyze somatic mutations found in smoking-related cancer datasets. We characterized mutational signatures that were consistent with those reported before in independent investigations. Our work demonstrates that selected mutational signatures correlated with specific clinical and molecular features across different cancer types, and revealed complementarity of specific mutational patterns that has not previously been identified. In conclusion, we proposemutSignaturesas a powerful open-source tool for detecting the molecular determinants of cancer and gathering insights into cancer biology and treatment.
Merqury: reference-free quality, completeness, and phasing assessment for genome assemblies
Authors: Rhie Arang , Walenz Brian P. , Koren Sergey , Phillippy Adam M. 
Published: March 2020

AbstractRecent long-read assemblies often exceed the quality and completeness of available reference genomes, making validation challenging. Here we present Merqury, a novel tool for reference-free assembly evaluation based on efficient k-mer set operations. By comparing k-mers in a de novo assembly to those found in unassembled high-accuracy reads, Merqury estimates base-level accuracy and completeness. For trios, Merqury can also evaluate haplotype-specific accuracy, completeness, phase block continuity, and switch errors. Multiple visualizations, such as k-mer spectrum plots, can be generated for evaluation. We demonstrate on both human and plant genomes that Merqury is a fast and robust method for assembly validation.Availability of data and materialProject name: MerquryProject home page: https://github.com/marbl/merqury, https://github.com/marbl/merylArchived version: https://github.com/marbl/merqury/releases/tag/v1.0Operating system(s): Platform independentProgramming language: C++, Java, PerlOther requirements: gcc 4.8 or higher, java 1.6 or higherLicense: Public domain (see https://github.com/marbl/merqury/blob/master/README.license) Any restrictions to use by non-academics: No restrictions applied
Temporal coordination of collective migration and lumen formation by antagonism between two nuclear receptors
Authors: Wang Xianping , Wang Heng , Liu Lin , Li Sheng , Emery Gregory , Chen Jiong 
Published: March 2020

SummaryDuring development, cells often undergo multiple, distinct morphogenetic processes to form a tissue or organ, but how their temporal order and time interval are determined remain poorly understood. Here we show that the nuclear receptors E75 and DHR3 regulate the temporal order and time interval between the collective migration and lumen formation of a coherent group of about 8 cells called border cells duringDrosophilaoogenesis. In wild type egg chambers, border cells need to first collectively migrate to the anterior border of oocyte before undergoing lumen formation to form micropyle, the structure that is essential for sperm entry into the oocyte. We show that E75 is required for border cell migration and it antagonizes the activity of DHR3, which is necessary and sufficient for the subsequent lumen formation during micropyle formation. Furthermore,E75’s loss of function orDHR3overexpression each leads to precocious lumen formation before collective migration, an incorrect temporal order for the two morphogenetic processes. Interestingly, both E75 and DHR3’s levels are simultaneously elevated in response to signaling from the EcR, a steroid hormone receptor that initiates border cell migration. Subsequently, the decrease of E75 levels in response to decreased EcR signaling leads to the de-repression of DHR3’s activity and hence switch-on of lumen formation, contributing to the regulation of time interval between collective migration and micropyle formation.
A dendritic-like microtubule network is organized from swellings of the basal fiber in neural progenitors
Authors: Coquand L. , Victoria G.S. , Tata A. , Brault J.B. , Guimiot F. , Fraisier V. , Baffet A. D. 
Published: March 2020

AbstractNeurons of the neocortex are generated by neural progenitors called radial glial cells. These polarized cells extend a short apical process towards the ventricular surface and a long basal fiber that acts as a scaffold for neuronal migration. How the microtubule cytoskeleton is organized in these cells to support long-range transport in unknown. Using subcellular live imaging within brain tissue, we show that microtubules in the apical process uniformly emanate for the pericentrosomal region, while microtubules in the basal fiber display a mixed polarity, reminiscent of the mammalian dendrite. We identify acentrosomal microtubule organizing centers localized in swellings of the basal fiber. We characterize their distribution and demonstrate that they accumulate the minus end stabilizing factor CAMSAP3 and TGN-related membranes, from which the majority of microtubules grow. Finally, using live imaging of human fetal cortex, we show that this organization is conserved in basal radial glial (bRG) cells, a highly abundant progenitor cell population associated with human brain size expansion.
Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vectorAnopheles funestus
Authors: Nouage Lynda , Elanga-Ndille Emmanuel , Binyang Achille , Tchouakui Magellan , Atsatse Tatiane , Ndo Cyrille , Kekeunou Sévilor , Wondji Charles S. 
Published: March 2020

AbstractInsecticide resistance genes are often associated with pleiotropic effects on various mosquito life-history traits. However, very little information is available on the impact of insecticide resistance, especially metabolic resistance, on blood feeding process in mosquitoes. Here, using two recently detected DNA-based metabolic markers in the major malaria vector,An. funestus, we investigated how metabolic resistance genes could affect blood meal intake.After allowing both field F1 and lab F8Anopheles funestusstrains to feed on human arm for 30 minutes, we assessed the association between key parameters of blood meal process including, probing time, feeding duration, blood feeding success and blood meal size, and markers of glutathione S-transferase (L119F-GSTe2) and cytochrome P450 (CYP6P9a_R) - mediated metabolic resistance. None of the parameters of blood meal process was associated withL119F-GSTe2genotypes. In contrast, forCYP6P9a_R, homozygote resistant mosquitoes were significantly more able to blood-feed than homozygote susceptible (OR = 3.3; CI 95%: 1.4-7.7; P =0.01) mosquitoes. Moreover, the volume of blood meal ingested by CYP6P9a-SS mosquitoes was lower than that of CYP6P9a-RS (P<0.004) and of CYP6P9a-RR (P<0.006). This suggests thatCYP6P9agene affects the feeding success and blood meal size ofAn. funestus. However, no correlation was found in the expression ofCYP6P9aand that of genes encoding for salivary proteins involved in blood meal process.This study suggests that P450-based metabolic resistance may increase the blood feeding ability of malaria vectors and potential impacting their vectorial capacity.
Prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Southern Ethiopia, 2018
Authors: Tunje Abayneh , Churko Chuchu , Haftu Desta , Alagaw Amsalu , Girma Eyayou 
Published: March 2020

AbstractBackgroundScabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have considerable impact on general health leading to illness and death not only through direct effect of its infestation and as a result of secondary bacterial infection. The aim of this study was to assess the prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Gamo zone, Southern Ethiopia.MethodsA community based cross sectional study was carried out in 845 school age children from February 20 to March 30, 2018. Multi-stage sampling technique was used to select study populations. Logistic regression an analysis was used to identify factors associated with scabies. Findings were presented using 95% CI of Crude Odds Ratios (COR) and Adjusted Odds Ratios (AOR. To declare statistical significance, p-value less than 0.05 was used.ResultA total of 825 children participated in the study with response rate of 97.6%. The overall prevalence of scabies was 16.4% [95% CI: 13.9%, 18.9%]. overcrowding index, family history of itching in the past two weeks, wealth index, knowledge of scabies, climatic zone, frequency of washing body, frequency of washing clothes, finger nails cutting practice, history of skin contact with scabies patient, washing hair more than once weekly, and sharing of clothes were significantly associated scabies disease.ConclusionIn conclusion, the prevalence of scabies in Arba Minch lies at 16.4% in the global scabies range 0.2% to 71.4%. The prevalence was highest in highlands followed by midland and then lowland. This represents a significant scabies burden which we recommend warrants health service intervention.Authors summaryScabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have considerable impact on general health leading to illness and death not only through direct effect of its infestation and as a result of secondary bacterial infection. Conducting a research on this neglected tropical disease would contribute in designing a policies and strategies on prevention and control measures in the study area. Therefore, the aim of this study was to assess the prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Gamo zone, Southern Ethiopia.
Characterization of the SARS-CoV-2 Spike in an Early Prefusion Conformation
Authors: Li Tingting , Zheng Qingbing , Yu Hai , Wu Dinghui , Xue Wenhui , Zhang Yuyun , Huang Xiaofen , Zhou Lizhi , Zhang Zhigang , Zha Zhenghui , Chen Tingting , Wang Zhiping , Chen Jie , Sun Hui , Deng Tingting , Wang Yingbin , Chen Yixin , Zhao Qinjian , Zhang Jun , Gu Ying , Li Shaowei , Xia Ningshao 
Published: March 2020

AbstractPandemic coronavirus disease 2019 (COVID-19) is caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which there are no efficacious vaccines or therapeutics that are urgently needed. We expressed three versions of spike (S) proteins—receptor binding domain (RBD), S1 subunit and S ectodomain—in insect cells. RBD appears monomer in solutions, whereas S1 and S associate into homotrimer with substantial glycosylation. The three proteins confer excellent antigenicity with six convalescent COVID-19 patient sera. Cryo-electron microscopy (cryo-EM) analyses indicate that the SARS-CoV-2 S trimer dominate in a unique conformation distinguished from the classic prefusion conformation of coronaviruses by the upper S1 region at lower position ~15 Å proximal to viral membrane. Such conformation is proposed as an early prefusion state for the SARS-CoV-2 spike that may broaden the knowledge of coronavirus and facilitate vaccine development.
What makes accounting interesting for learners? Viewpoint of a teacher from India
Authors: Narayanasamy Sivasankaran 
Published: March 2020

PurposeThe article aims to share the viewpoint of the author on the impact of the innovative teaching pedagogy adopted by him in teaching the accounting courses on the satisfaction of the participants in a premier Indian Business School.Design/methodology/approachThe experiment was carried over by introducing an innovative teaching approach by the author among the first-year participants of the Management Program. At the end of the experiment, the participants were asked to rate the teaching approach on a five-point scale besides offering the qualitative feedback on the impact of the experiment on their learning outcomes.FindingsThe paper concludes that the participants were highly satisfied with the teaching approach adopted by the author.Originality/valueThe study contributes to the theory and practitioners on accounting education in many ways. First, it is offering evidence on the impact of teaching pedagogy on the satisfaction of the participants of the accounting courses of an emerging market business school. Second, the accounting educators of the emerging countries may replicate the experiment in their institutes. Third, the educators of other courses in the business schools may make an effort to measure the impact of the teaching approach on the feedback of their learners.
Geographical cues: evidences from New and Old World countries' wine consumers
Authors: Giacomarra Marcella , Galati Antonino , Crescimanno Maria , Vrontis Demetris 
Published: March 2020

PurposeThis systematic review aims to investigate how geographical cues affect wine consumers' behaviors, with reference to the New and Old Worlds, and accordingly, how are recent consumption patterns and new consumer profiles modifying roles of geographical cues?Design/methodology/approachThis work employed a systematic literature review methodology on the extant literature published from 2009 to 2019.FindingsResults, summarized in a conceptual framework, emphasize five thematic areas on how geographical cues should be considered for future research and for new marketing strategies to capture consumers of New and Old World wines. Consumers' wine knowledge, socio-ethno-demographic factors, consumption settings, labeling strategies and the use of medals and awards on labels emerged as relevant factors to deal with consumer's risk-reduction strategies.Research limitations/implicationsThe main limit is the adoption of a systematic review method.Practical implicationsResults suggest that wine managers should invest in acquiring more knowledge about consumers' profiles in both Worlds for their marketing campaigns, labeling and advertisement strategies. Although geographical cues are considered relevant in consumers' buying decisions, extrinsic cues are also increasingly acceptable, and there should be more investment in publicizing geographical attributes around the world.Originality/valueThis is the first review focusing exclusively on the role of geographical cues on consumer's behavior toward New and Old World wine producers.
Sustainable crowdfunding: insights from the project perspective
Authors: Maehle Natalia 
Published: March 2020

PurposeThis paper explores the peculiarities of sustainable crowdfunding from the project perspective. The research question is: what are the distinctive features of sustainable crowdfunding, in terms of crowdfunding motivation, platform choice, crowdfunding costs and relationships with backers?Design/methodology/approachThe current study follows a qualitative approach, through conducting in-depth interviews with representatives of sustainable projects, which have had successful crowdfunding campaigns. The selected projects represent various industries and crowdfunding models.FindingsSustainable entrepreneurs have both financial and non-financial motivations for crowdfunding. A distinctive feature is the importance of community engagement, since the community spirit of crowdfunding is well suited to sustainable projects. The choice of the crowdfunding platform is more complex for sustainable entrepreneurs, as they need to consider the platform's sustainability. Sustainable entrepreneurs also have to put more effort into their communication activities with potential backers, to compensate for the intangibility of sustainability claims. Moreover, they need to have a greater focus on building relationships with backers due to both the community spirit of their projects and legitimacy issues.Originality/valueThe current paper contributes to the limited literature on sustainable crowdfunding and the literature on funding of sustainable businesses and can act as a foundation for further research in this field. Current findings also have high practical value. Crowdfunding platforms may use the insights provided here to better meet the needs of sustainable entrepreneurs, while sustainable entrepreneurs can better understand what they need to pay attention to in their crowdfunding campaigns.
Archies limited: where have all the feelings gone?
Authors: Nandi Subrata Kumar , Saxena Manisha , Vadehra Pallvi 
Published: March 2020

Learning outcomes
The learning outcomes are to get an understanding of the greeting cards (GCs) industry – appreciate the evolution of the industry and the changes that have been impacting the industry; analyze the external environment situation and assess the current strategy of Archies; analyze the existing strategy of Archies and apply the knowledge of strategic frameworks to the current business context of Archies; and create a new strategy for the company to overcome its current challenges.

Case overview/synopsis
The case highlights the situation faced by Archies Limited, a company, which pioneered the growth of the social expression industry in India and developed the market for GCs, a quintessentially Western concept in the Indian market. While it experienced phenomenal growth for two and a half decades, in the past 10 years, things have become more difficult for the company. Based on secondary data, this case presents various facts related to the case and seeks answers related to possible strategies that the firm may explore in the future.

Complexity academic level
Undergraduate and postgraduate management course in the area of strategic management. The level of difficulty can be from medium to high depending on the learning level.

Supplementary materials
Teaching Notes are available for educators only.

Subject code
CSS 11: Strategy.
Too much of a good thing
Authors: Cavazotte Fláviade Souza Costa Neves , Paula Fábio de Oliveira 
Published: March 2020

PurposeThis study investigates the influence of shared leadership on creativity and absorptive capacity in R&D teams. Based on theories of intragroup processes, it proposes that shared leadership positively affects such team outcomes up to a certain point, but at very high levels could cause loss of synergy and effectiveness, and therefore the relationship will follow an inverted U-shaped curve.Design/methodology/approachThe study was conducted with 76 independent teams from the R&D unit of one of the largest energy companies in Brazil. Data were collected with two questionnaires answered by external team managers and team members. The study applied structural equation modeling to test the hypotheses.FindingsResults indicate that there is a curvilinear relationship between shared leadership and external assessments of creativity and absorptive capacity in R&D teams. Although leadership shared among team members tends to favor creativity and realized absorptive capacity, at very high levels it yielded less than optimal outcomes. Team creativity had a direct positive effect on the teams' ability to explore and transform knowledge.Originality/valueThe study is the first empirical test of the influence of shared leadership on team creativity and absorptive capacity that proposes and confirms a quadratic effect. These results shed new light on the authors’ understanding of how intrateam leadership affects creative processes and absorptive capacity in the R&D context. These findings offer novel insights to inform practice as firms manage innovation performance.
The effect of organizational culture and HR practices on female managers’ commitment and job satisfaction
Authors: Park Sunyoung , Doo Min Young 
Published: March 2020

PurposeThe purpose of this study is to investigate the structural relationships among organizational culture, human resources (HR) practices and female managers’ organizational commitment and job satisfaction in South Korea.Design/methodology/approachUsing data obtained from the Korean Women Manager Panel, 230 responses were analyzed using structural equation modeling.FindingsThe findings indicated that organizational culture directly affected HR practices and indirectly affected job satisfaction and organizational commitment. In addition, HR practices directly influenced job satisfaction and organizational commitment and indirectly affected organizational commitment through job satisfaction. Finally, job satisfaction had a direct and significant effect on organizational commitment.Originality/valueThe authors provide an empirical analysis of how organizational culture and functional factors influence organizational commitment and job satisfaction for female managers in the Korean context. The findings of this paper are expected to encourage scholars to pay more attention to the connection between organizational support and HR interventions to improve female managers’ commitment and satisfaction within organizations by emphasizing the alignment between organizational culture and HR practices.