bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparison of the effect of flaxseed oil and vitamin E on mastalgia and nodularity of breast fibrocystic: a randomized double-blind clinical trial
Authors: Godazandeh Gholamali , Ala Shahram , Motlaq Tahereh Madani , Sahebnasagh Adeleh , Bazi Aliyeh 
Published: January 2021

Abstract
Background
Fibrocystic changes are a common benign condition in women aged 20–50. The medical intervention aims to stop fibrocystic disease progress and relieve the breast’s pain and tenderness. In the long-term, reversing the fibrocystic changes is also desirable.

Methods
In this randomized double-blind clinical trial, the effect of flaxseed oil on the severity of pain and breast nodularity was investigated against vitamin E. This study was conducted on 100 women with mastalgia. The intervention group received Flaxseed oil pearls and the control group received vitamin E pearl 200 IU twice a day for 2 months. The duration and severity of breast pain were evaluated by Cardiff chart and VAS (Visual Analogue Scale). The nodularity was assessed by Lucknow-Cardiff scale at baseline, then the first and second months of intervention.

Results
At baseline, there was no statistically significant difference between the two groups in characteristics. The breast pain improved in both groups during the first and second months of intervention (P-value within group< 0.001). However, the mean breast pain was not significantly different between the two groups at the end of the first and second month (P1= 0.54, P2= 0.73). Furthermore, the breast pain during four phases of the menstrual cycle showed no difference between vitamin E and flaxseed oil groups (menstruation phase= 0.76, follicular phase= 0.48, the first week of luteal phase= 0.86, the second week of luteal phase=0.30). The breast nodularity also decreased during the first and second months of intervention, yet no significant difference between the two groups was found (p= 0.9).

Conclusions
This study showed that flaxseed oil and vitamin E both could be effective in breast pain-relieving and decreasing nodularity with minimal side effects in contrast with the baseline. But there are no significant differences between these two agents. Larger scale prospective studies are needed to evaluate these effects in the long-term.

Trial registration
IRCT201612243014N18, Registration date: 2017-10-15.
The therapeutic strategy for advanced gastric cancer with pyloric stenosis and liver metastasis; successfully treated by gastro-jejunal bypass and chemotherapy first, followed by curative R0 resection
Authors: Nakamichi Naosuke , Tsujiura Masahiro , Matsui Tomohiro , Yamamoto Taiga , Yoshioka Ayana , Hiramoto Hidekazu , Ouchi Yoshimi , Ishimoto Takeshi , Kosuga Toshiyuki , Mochizuki Satoshi , Nakashima Susumu , Bamba Masamichi , Masuyama Mamoru , Otsuji Eigo 
Published: January 2021

AbstractBackgroundThe indication of surgical resection for liver metastasis from gastric cancer (GC) is still limited and controversial because of its more aggressive oncological characteristics than liver metastasis from colorectal cancer. Pyloric stenosis causes an inadequate oral intake and malnutrition in GC patients. We herein report a case of GC with these two factors that was successfully treated by the combination of gastro-jejunal bypass and chemotherapy, followed by curative R0 resection.Case presentationA 60-year-old man was diagnosed with type 2 GC with liver metastasis and pyloric stenosis, which was confirmed as the HER2-positive type. He underwent gastrojejunostomy and received capecitabine and cisplatin (XP) + trastuzumab chemotherapy. After three courses of the XP + trastuzumab regimen, shrinkage of the primary lesion and liver metastasis was confirmed and his nutritional parameters markedly improved with a stable oral intake after bypass surgery. He underwent curative R0 resection by distal gastrectomy with D2 lymphadenectomy and partial hepatectomy. Histologically, viable tumor cells were observed in less than one-third of the primary lesion, and only scar tissue without viable cancer cells was noted in the resected liver specimen. His postoperative course was uneventful, and recurrence has not been detected in the 30 months after surgery without adjuvant chemotherapy.ConclusionThe present case report describes a successful strategy for advanced GC with pyloric stenosis and liver metastasis.
Efficacy of laparoscopic sleeve gastrectomy for patient with morbid obesity and type 1 diabetes mellitus: a case report
Authors: Ichikawa Hidetaka , Imoto Hirofumi , Tanaka Naoki , Musha Hiroaki , Sawada Shojiro , Naitoh Takeshi , Kamei Takashi , Unno Michiaki 
Published: January 2021

Abstract
Background
Bariatric surgery is effective for the treatment of patients with morbid obesity and type 2 diabetes mellitus (T2DM), for body weight loss and glycemic control. However, in Japan, there has been no previous report of the effectiveness bariatric surgery in a case of morbid obesity associated with acute onset type 1 diabetes mellitus (T1DM), in which pancreatic β-cells were destroyed and endogenous insulin was depleted.

Case presentation
A 36-year-old woman with morbid obesity and T1DM, diagnosed when she was 6 years, was admitted for bariatric surgery. At her first consultation, she had a body weight of 106.7 kg and a body mass index of 42.2 kg/m2. Her HbA1c level was 9.0%, with a required daily insulin dose of 75 units. She underwent laparoscopic sleeve gastrectomy. At 1 year after surgery, her body weight had decreased to 81.0 kg and her body mass index to 32.2 kg/m2. In addition, her daily required dose of insulin had decreased to 24 units, with an improvement in her HbA1c level to 7.7%.

Conclusions
Although further evidence needs to be accumulated, including long-term outcomes, laparoscopic sleeve gastrectomy may provide an effective treatment for patients with morbid obesity and T1DM for body weight loss, improvement in HbA1c level, and insulin dose reduction.
Spontaneous regression of breast cancer with immune response: a case report
Authors: Ohara Masahiro , Koi Yumiko , Sasada Tatsunari , Kajitani Keiko , Mizuno Seishi , Takata Ai , Okamoto Atsuko , Nagata Ikuko , Sumita Mie , Imachi Kaita , Watanabe Mayumi , Daimaru Yutaka , Kawamura Shingo 
Published: January 2021

Abstract
Background
Spontaneous regression (SR) is a rare phenomenon in which a cancer disappears or remits without treatment. We report a case of breast cancer that showed spontaneous tumor regression in the surgical specimen after core needle biopsy.

Case presentation
A 59-year-old woman came to our hospital complaining of a painful lump in the right breast. In the upper-outer quadrant of the right breast, a tumor with an unclear boundary, 30 mm in diameter, was palpable. In pathological findings from needle biopsy, the tumor was diagnosed as solid-type invasive ductal breast carcinoma. Partial coagulation necrosis was generated in estrogen receptor-negative, HER2-negative, and AE1/AE3-positive ductal carcinoma without infiltration of lymphocytes. Surgery for right breast cancer was then performed. Histological examination of the surgical specimen revealed the tumor was invasive ductal carcinoma with lymphocyte infiltration, coagulation necrosis, and fibrous tissue with hemosiderin. The tumor formed a solid nest, 3 mm in diameter, suggesting the possibility of SR.

Conclusions
Immune responses, infection, hormones, surgical stress, and ischemia have been reported as mechanisms of SR. The findings in this case strongly suggest that SR of breast cancer is associated with anti-tumor immune responses.
The Surfer’s Shoulder: A Systematic Review of Current Literature and Potential Pathophysiological Explanations of Chronic Shoulder Complaints in Wave Surfers
Authors: Langenberg Lisette Charlotte , Vieira Lima Guilherme , Heitkamp Sebastiaan Emanuel , Kemps Floortje Lutgart Arnoldus Maria , Jones Matthew Simon , Moreira Miguel António de Almeida Garcia , Eygendaal Denise 
Published: January 2021

Abstract
Background
Wave surfing will debut in the next Olympic Games and is increasingly popular as a sport. Chronic shoulder complaints are frequently reported amongst surfers, though literature researching its pathophysiology and prevention is scarce. This article provides an overview of the current literature, proposes a potential pathogenesis and a potential physiotherapeutic prevention program for surf-induced shoulder complaints.

Methods
A systematic review was performed considering the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for articles regarding kinematic analysis of the surf paddling movement. Data sources were Embase, MEDLINE (PubMed) and Research gate. We included case series and cohort studies that originally studied or described the paddle movement made by wave surfers, studies that reported on kinesiologic analysis with nerve conduction studies and studies on 3D motion analysis of the shoulder while paddling.

Results
Eight original articles were included that analysed the shoulder movement in paddling surfers. Muscles that are active during paddling are mainly internal rotators and muscles that are involved in shoulder flexion. Internal rotators are active in propelling the surfer through the water, though external rotator strength is only used while the arm is out of the water.

Discussion
In surfers with shoulder complaints, external rotation range of motion and external rotation strength are impaired. Scapulothoracic dyskinesis may occur and subacromial pain syndrome may coincide. Further research should address potential pectoralis minor shortening, which may lead to aberrant scapular tilt and lateral rotation of the scapula. The surfer’s shoulder is characterised by external rotation deficit, as opposed to internal rotation deficit in the thrower’s shoulder, and it differs substantially from shoulder complaints in swimmers. Therefore, a specific prevention or rehabilitation protocol for surfers is required. Decreased thoracic extension may thereby alter the risk of scapular dyskinesis and hence increase the risk of impingement around the shoulder joint. A potential physiotherapeutic prevention programme should address all these aspects, with the main goal being to increase external rotator strength and to stretch the internal rotators.

Conclusion
There is a high incidence of chronic surf-induced shoulder complaints in surfers. Symptoms may arise due to imbalanced training or scapular dyskinesis, which may subsequently trigger subacromial pain. Physiotherapeutic prevention should include stretching of the internal rotators, external rotator training and optimisation of thoracic extension and scapulothoracic movement.
Current technology for identifying dental implants: a narrative review
Authors: Saghiri Mohammad Ali , Freag Peter , Fakhrzadeh Amir , Saghiri Ali Mohammad , Eid Jessica 
Published: January 2021

Abstract
Background
This paper outlines the current status and mechanism for identifying dental implants, with emphasis on future direction and updated technology, and covers the existing factors influencing the identification of implant systems.

Main body
A search was performed on the current methods of identifying dental implants between January 2000 through Feb 2020 using online databases for articles published in English. The search was performed using the Google, Rutgers library, PubMed, MEDLINE databases via OVID using the following keywords: implant types identification by x-ray imaging, forensic identification of dental implant, surface types, threaded, non-threaded, software identification, recent technologies, which evaluated different methods in the identification of dental implants and its clinical importance for the dentist and the patient. Of the 387 articles found in initial search results, 10 met the inclusion criteria set for this review. These 10 studies were directly related to the identification of different implant systems. Many studies have indicated identifying dental implants as problematic due to many confounding factors, and the difficulty in finding the specific parts for the dental implant itself. The contribution of digital dentistry is critical. Factors like increasing number of implant manufacturers, dental tourism, and cost, make it difficult to detect and match dental implants by dentists during the chairside time.

Conclusion
These factors give rise to the need for a new system to help clinicians in decision making. Artificial intelligence seems to have shown potential to help in this case. However, detailed regulatory mechanisms are still needed for diagnosis and analysis.
Musculoskeletal ultrasonographic evaluation of perineural injection therapy versus therapeutic ultrasound in chronic lateral epicondylitis
Authors: El-Badawy Mohja Ahmed , El-Nagaar Hanaa Ahmed , Mohammed Mona Mansour , Assaf Naglaa Youssef , EL-Mallah Reem Mohammed Ezz El-Din 
Published: January 2021

Abstract
Background
Lateral epicondylitis (LE) is a common disorder causing pain and functional limitations especially in athletes and manual workers. There is a growing interest in regenerative injection therapies in chronic LE. One of those suggested is perineural injection (PNI) therapy. The present study aims to find out the efficacy of PNI therapy in the treatment of chronic LE as compared to therapeutic ultrasound (TUS) and to detect if any changes have happened after treatment to the common extensor tendon (CEO) as detected by diagnostic ultrasound (US) examination.

Results
Statistical analysis between the 2 groups at the start of the study as regards age, sex, and clinical parameters including visual analog scale (VAS), tenderness grading scale, and Patient-Rated Tennis Elbow Evaluation (PRTEE) Questionnaire revealed a non-significant difference between both groups (p > 0.05). After 12 weeks, within-group analysis showed significant improvement in all clinical outcome measures in both groups compared to the initial assessment.
Between-group analysis after 12 weeks showed that the tenderness grading scale and PRTEE score had more significant improvement in the PNI therapy group. However, the two groups were comparable regarding VAS. Within-group US evaluation at the 12th week post-treatment showed a highly significant decrease in hypoechoic areas (p < 0.001) and a decrease in distributed fibrillar pattern in PNI group, while the TUS group demonstrated a significant decrease in hypoechoic areas and tendon thickness (p < 0.005). Between-group US evaluation after 12 weeks showed no significant difference in all assessed US parameters. No complications were observed in both groups.

Conclusions
A short-term follow-up regimen of 1 session/week of PNI therapy is significantly more effective than 3 sessions/week of TUS regarding the improvement of pain and functional status. Yet both therapeutic modalities were able to produce significantly positive structural changes in the CEO. The current study highlights the neurogenic inflammation as the primary pain generator in chronic LE and the advantage of its treatment with PNI therapy in chronic and refractory cases.
Adding ceramic polishing waste as filler to reduce paste volume and improve carbonation and water resistances of mortar
Authors: Li Leo Gu , Ouyang Yi , Zhuo Zhen-Yao , Kwan Albert Kwok Hung 
Published: January 2021

AbstractThe use of ceramic waste in concrete/mortar production as aggregate replacement or cement replacement has been under consideration in the last decade to find an effective way to tackle the growing hazard of ceramic waste disposal. In this study, the authors reutilize ceramic polishing waste (CPW) as a filler to replace an equal volume of cement paste in mortar while keeping the mixture proportions of the cement paste unchanged, i.e., in a new way as paste replacement. This mixture design strategy allows a larger amount of CPW to be added to substantially reduce the paste volume, cement and carbon footprint. The mortar mixes so produced had been subjected to carbonation and water absorption tests, and the results showed that as paste replacement, the CPW can significantly enhance the carbonation and water resistances, in addition to the environmental benefits of reducing waste, cement and carbon footprint. Regression analysis of test results indicated that for carbonation resistance, the cementing efficiency factor of the CPW was around 0.5, whereas for water resistance, the cementing efficiency factor was higher than 1.0 at low CPW content and lower than 1.0 at high CPW content.
Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs
Authors: Qiao Fangfang , Law Henry C.-H. , Krieger Kimiko L. , Clement Emalie J. , Xiao Yi , Buckley Shannon M. , Woods Nicholas T. 
Published: January 2021

ABSTRACT
RNA polymerase II subunit A Carboxy-Terminal Domain Phosphatase 1 (CTDP1), a member of the haloacid dehalogenase superfamily phosphatases, has a defined role in transcriptional regulation, but emerging evidence suggests an expanded functional repertoire in the cell cycle and DNA damage response. In humans, a splice site mutation in CTDP1 gives rise to the rare Congenital Cataracts Facial Dysmorphism and Neuropathy syndrome, and recent evidence from our lab indicates CTDP1 is required for breast cancer growth and proliferation. To explore the physiological function of CTDP1 in a mammalian system, we generated a conditional Ctdp1 knockout mouse model by insertion of loxP sites upstream of exon 3 and downstream of exon 4. Biallelic deletion of Ctdp1 results in lethality before embryonic day 7.5, with morphological features indicating embryo cell death and resorption. However, Ctdp1+/− mice are haplosufficient for phenotypic traits including body weight, hematological parameters, exploratory and locomotive functions. To investigate the potential mechanisms of the embryonic death caused by biallelic Ctdp1 knockout, mouse embryonic fibroblasts (MEFs) were established from Ctdp1+/+ and Ctdp1flox/flox mice. Lentivirus delivered Cre-mediated biallelic deletion of Ctdp1 in MEFs results in cell death preceded by impaired proliferation characterized by an increase in G1- and G2-phase populations and a reduction in the S-phase population. These cell cycle alterations caused by deletion of Ctdp1 are associated with an increase in p27 protein expression and a decrease in phosphorylated RB, phosphorylated Histone H3, and Cyclin B expression. Together, these results reveal that Ctdp1 plays an essential role in early mouse embryo development and cell growth and survival in part by regulating the cell cycle.
Eggshell membrane for DNA sexing of the endangered Maleo (Macrocephalon maleo)
Authors: Yuda Pramana , Saputra Andie Wijaya 
Published: January 2021

Background: Noninvasive DNA sampling has been applied across many avian genetic studies for a variety of purposes including conservation and management of endangered birds. However, its application in megapodes is still lacking. The previous genetic studies on megapodes used either blood or fresh tissue. Here we present the first demonstration of the use of eggshell membrane for research on endangered Maleo (Macrocephalon maleo). Methods: We used 24 post-hatched eggshell membranes collected from two different sites, Tambun and Tanjung Binerean, in North Sulawesi, 12 samples in each. Two different DNA extraction methods: alkaline lysis method and gSYNCTM DNA Extraction Kit were applied. To determine the sex of Maleo, we utilized PCR-based DNA sexing using CHD genes, with the primer set 2550F/2718R. Results: We successfully extracted all samples; the mean sample concentration was 267.5 ng/µl (range 47–510.5 ng/µl) and samples were of high purity (A260/280 ratio 1.85±0.03). All samples were used to successfully identified sexes, 9 females and 15 males. Conclusions: Our research clearly illustrates that eggshell membranes can be used for DNA sexing and open the possibility to build noninvasive DNA collections over large spatial scales for population study of endangered birds.
Apólice de seguro contra cheias para a sustentabilidade dos investimentos
Authors: Gonçalves Maria da Glória Salgado 
Published: January 2021

A localização das ocorrências de cheias e a tipologia das consequências, a responsabilidade das seguradoras e a confiança dos cidadãos tem-se como uma abertura ao debate das políticas sobre os investimentos sustentáveis. Os factos justificam-se com dados da imprensa periódica, regional e local, que fornece descrições detalhadas sobre as ocorrências, com uma aproximação à realidade testada em 84,3% para a Bacia Hidrográfica do rio Vez, entre 1900 e 2015. A inovação desta investigação tem a ver com a atribuição da apólice do seguro tendo em conta a distância entre o ponto que identifica o elemento exposto e o curso do rio mais próximo, e o número de meses mais chuvosos, que desencadeiam as cheias num determinado local. A utilidade da metodologia permite ainda avaliar e reajustar, ao longo do tempo, os efeitos dos fatores e políticas sobre o valor das propriedades e/ou imóveis. Estes fatores contribuem para uma poupança dos investimentos para o estado, as empresas de seguros e para os segurados, que devido à criação da necessidade, provocará um reajuste da taxa de adesão ao seguro para a proteção contra este perigo. Assim, pretende-se demonstrar que a partir dos dados da frequência das cheias, da relação destas com a distância ao rio e dos meses do ano mais chuvosos, pode ser atribuído um valor da apólice de seguro mais justo para as partes interessadas, readaptando-o para a sustentabilidade hidrológica e dos investimentos. As adaptações da apólice melhoram as condições e a segurança contra este perigo.
Kompetensi Manajerial Kepala Sekolah dalam Meningkatkan Prestasi Non Akademik Siswa SMP
Authors: Yulista Karlina , Samiha Yulia Tri , Zainuri Ahmad 
Published: January 2021

Tujuan dari penelitian ini untuk mengetahui bagaimana prestasi non akademik siswa pada bidang keagamaan baca tulis al-qur’an dan da’i/da’iyah. Jenis penelitian yang digunakan yaitu penelitian kualitatif. Insrumen penelitian menggunakan dokumentasi, wawancara, observasi serta triangulasi. Kemudian analisis data menggunakan reduksi, penyajian data dan verifikasi data. Hasil penelitian dapat disimpulkan bahwa 1) perencanaan yaitu kepala sekolah melakukan: perumusan visi dan misi, menyusun rencana strategi, menyusun rencana kegiatan tahunan dan menyusun anggaran kegiatan; 2) Pengelolaan Kesiswaan yaitu: Pengelolaan kegiatan Keagamaan, Pengelompokan dan orientasi, Pembinaan dan Sistem reward/penghargaan terhadap siswa yang berprestasi; 3) Pengawasan dan evaluasi mencakup: pengawasan preventif dan pengawasan kolektif, dan evaluasi mencakup; absensi dan buku kontrol siswa.; 4) Kendala yang dihadapi kepala sekolah dalam meningkatkan prestasi non akademik siswa yaitu; minim pendanaan, kurangnya tenaga Koordinator Pembina Rohis dan tidak disiplinnya siswa mengikuti kegiatan Keagamaan Baca Tulis Al-Qur’an dan da’i/da’iyah.