bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo
Authors: Zhou Qingchun , Yu Juan , Zheng Qingyou , Wu Tao , Ji Ziliang , Zhuo Yumin 
Published: November 2019

Bladder cancer is one of the most common malignant tumors of the urinary system, with high morbidity and mortality. At present, the survival rates and prognosis of patients with bladder cancer are still relatively low; thus, there remains a need to improve prognosis by identifying novel targets. Kinesins (kinesin superfamily proteins) are a series of microtubule‐based motor proteins that mediate various types of cellular processes. Kinesin family member 3A (KIF3A) is critical for cytoplasm separation in mitosis, and it has been reported to be misexpressed in multiple types of cancer. However, its effects on the progression and development of bladder cancer remain unclear. Herein, we report that KIF3A is highly expressed in human bladder cancer. We identified a significant correlation between KIF3A and clinical features, including clinical stage (P = 0.047), pathological tumor status (P = 0.045), lymph node status (P = 0.041) and metastasis (P = 0.035). KIF3A expression was also correlated with poor prognosis of patients with bladder cancer. Our results further indicated that KIF3A ablation resulted in cell cycle arrest; blocked the proliferation, migration and invasion of bladder cancer cells in vitro; and restrained tumor growth in mice in a microtubule‐dependent manner. In summary, our findings suggest that KIF3A is a potential therapeutic target for bladder cancer.
Bioinspired Cell Nuclear Nanotransporters Generated by Self‐Assembly of Amphiphilic Polysaccharide‐Amino Acid Derivatives Conjugates
Authors: Nagahama Koji , Sano Yoshinori , Inui Mitsuo , Aoyama Seika , Katayama Tokitaka , Ono Kimika 
Published: November 2019

AbstractDevelopment of nanomaterials that surely transport functional biomacromolecules and bioactive synthetic compounds into the cell nucleus must be promising for the generation of nuclear‐targeting new technologies. However, the development of nuclear transporting nanomaterials thus still remains a significant challenge, because molecular transport between the cytoplasm and the nucleus of a eukaryotic cell is strictly regulated by the sole gateway through the nuclear envelope, the nuclear pore complexes (NPCs). Here, the rational design of novel artificial nuclear nanotransporters (NucPorters), inspired by importin, naturally occurring nuclear transporters is shown. The NucPorter is generated by simple molecular design: self‐assembly of amphiphilic polymers, where a few numbers of hydrophobic amino‐acid derivatives with phenyl groups are conjugated to negatively charged hydrophilic heparin. The NucPorter can mimic essential structural and chemical features of importin machinery to pass through the NPCs. Importantly, the NucPorter demonstrates remarkable rapid and high efficient nuclear transport in cultured cells, tissue/organ, and living mice. Moreover, the NucPorter successfully imports both enzymes and synthetic anticancer drugs into the nucleus while maintaining their bioactivity. Thus, the NucPorter provides a promising new route to generate innovative nuclear‐targeting medicines, diagnostics, cell imaging and engineering techniques, and drug delivery systems.
Biomimetic Mineralized Organic–Inorganic Hybrid Macrofiber with Spider Silk‐Like Supertoughness
Authors: Yu Yadong , He Yan , Mu Zhao , Zhao Yueqi , Kong Kangren , Liu Zhaoming , Tang Ruikang 
Published: November 2019

AbstractSpider silk fibers (SSF) have a hierarchical structure composed of proteins with highly repetitive sequences and biomineralization is sophisticated in hierarchical organic–inorganic constructions. By using inorganic hydroxyapatite (HAP) and organic polyvinyl alcohol (PVA) to simulate the rigid crystalline and flexible amorphous protein blocks of SSF, respectively, biomimetic mineralization is herein attempted for the large‐scale preparation of SSF‐like macrofibers with a hierarchical ordered structure, a superhigh tensile strength of 949 ± 38 MPa, a specific toughness of 296 ± 12 J g−1, and a stretch ability of 80.6%. The hybrid macrofibers consist of microfibers, and their outstanding performance (e.g., extreme tolerance to temperatures ranging from −196 to 80 °C and superior ability to inhibit the transverse growth of cracks) is attributed to the hierarchical arrangement as well as the organic–inorganic integrated structure within the oriented mineralized polymer chains. The biomineralization‐inspired technique provides a promising tactic that can be used to synthesize functional organic–inorganic fibers that are structurally complex and, furthermore, industrially manufacture SSF‐like artificial fibers with a supertoughness.
Temperature‐Invariant Superelastic and Fatigue Resistant Carbon Nanofiber Aerogels
Authors: Li Chao , Ding Yan‐Wei , Hu Bi‐Cheng , Wu Zhen‐Yu , Gao Huai‐Ling , Liang Hai‐Wei , Chen Jia‐Fu , Yu Shu‐Hong 
Published: November 2019

AbstractSuperelastic and fatigue‐resistant materials that can work over a wide temperature range are highly desired for diverse applications. A morphology‐retained and scalable carbonization method is reported to thermally convert a structural biological material (i.e., bacterial cellulose) into graphitic carbon nanofiber aerogel by engineering the pyrolysis chemistry. The prepared carbon aerogel perfectly inherits the hierarchical structures of bacterial cellulose from macroscopic to microscopic scales, resulting in remarkable thermomechanical properties. In particular, it maintains superelasticity without plastic deformation even after 2 × 106 compressive cycles and exhibits exceptional temperature‐invariant superelasticity and fatigue resistance over a wide temperature range at least from −100 to 500 °C. This aerogel shows unique advantages over polymeric foams, metallic foams, and ceramic foams in terms of thermomechanical stability and fatigue resistance, with the realization of scalable synthesis and the economic advantage of biological materials.
Piezoelectric Actuators and Motors: Materials, Designs, and Applications
Authors: Gao Xiangyu , Yang Jikun , Wu Jingen , Xin Xudong , Li Zhanmiao , Yuan Xiaoting , Shen Xinyi , Dong Shuxiang 
Published: November 2019

AbstractPiezoelectric actuators are unique driving force‐generation devices, which can transfer input electric energy into force, displacement, or movement outputs efficiently and precisely via piezoelectric effect‐based electromechanical coupling instead of electromagnetic induction. In comparison with traditional electromagnetic actuators, the most important features of the piezoelectric actuators are their compact size, flexible design, and ability to provide nanometer or sub‐micrometer positioning. Here, recent progress in nonresonance piezoelectric actuators including multilayer ceramic actuators, step motors, inertial motors, and resonance ultrasonic motors, such as linear motors, rotary motors, multidegree of freedom motors, and microelectromechanical system actuators, is comprehensively presented. The working principles and properties of these actuators are explained, and the piezoelectric materials and configurations, fabrication, and applications are provided. Furthermore, from the aspects of materials, designs and applications, challenges and outlooks for future developments of piezoelectric actuators and motors are also discussed.
B(C6F5)3‐Catalyzed α‐Deuteration of Bioactive Carbonyl Compounds with D2O
Authors: Chang Yejin , Myers Tanner , Wasa Masayuki 
Published: November 2019

AbstractAn efficient deuteration process of α‐C−H bonds in various carbonyl‐based pharmaceutical compounds has been developed. Catalytic reactions are initiated by the action of Lewis acidic B(C6F5)3 and D2O, converting a drug molecule into the corresponding boron‐enolate. Ensuing deuteration of the enolate by in situ‐generated D2O+−H then results in the formation of α‐deuterated bioactive carbonyl compounds with up to >98% deuterium incorporation.magnified image
Porous g‐C3N4 and MXene Dual‐Confined FeOOH Quantum Dots for Superior Energy Storage in an Ionic Liquid
Authors: Shi Minjie , Xiao Peng , Lang Junwei , Yan Chao , Yan Xingbin 
Published: November 2019

AbstractOwing to their unique nanosize effect and surface effect, pseudocapacitive quantum dots (QDs) hold considerable potential for high‐efficiency supercapacitors (SCs). However, their pseudocapacitive behavior is exploited in aqueous electrolytes with narrow potential windows, thereby leading to a low energy density of the SCs. Here, a film electrode based on dual‐confined FeOOH QDs (FQDs) with superior pseudocapacitive behavior in a high‐voltage ionic liquid (IL) electrolyte is put forward. In such a film electrode, FQDs are steadily dual‐confined in a 2D heterogeneous nanospace supported by graphite carbon nitride (g‐C3N4) and Ti‐MXene (Ti3C2). Probing of potential‐driven ion accumulation elucidates that strong adsorption occurs between the IL cation and the electrode surface with abundant active sites, providing sufficient redox reaction of FQDs in the film electrode. Furthermore, porous g‐C3N4 and conductive Ti3C2 act as ion‐accessible channels and charge‐transfer pathways, respectively, endowing the FQDs‐based film electrode with favorable electrochemical kinetics in the IL electrolyte. A high‐voltage flexible SC (FSC) based on an ionogel electrolyte is fabricated, exhibiting a high energy density (77.12 mWh cm−3), a high power density, a remarkable rate capability, and long‐term durability. Such an FSC can also be charged by harvesting sustainable energy and can effectively power various wearable and portable electronics.
Stable Li Metal Anode Enabled by Space Confinement and Uniform Curvature through Lithiophilic Nanotube Arrays
Authors: Tantratian Karnpiwat , Cao Daxian , Abdelaziz Ahmed , Sun Xiao , Sheng Jinzhi , Natan Avi , Chen Lei , Zhu Hongli 
Published: November 2019

AbstractThe application of lithium (Li) metal anodes in rechargeable batteries is primarily restricted by Li dendrite growth on the metal's surface, which leads to shortened cycle life and safety concerns. Herein, well‐spaced nanotubes with ultrauniform surface curvature are introduced as a Li metal anode structure. The ultrauniform nanotubular surface generates uniform local electric fields that evenly attract Li‐ions to the surface, thereby inducing even current density distribution. Moreover, the well‐defined nanotube spacing offers Li diffusion pathways to the electroactive areas as well as the confined spaces to host deposited Li. These structural attributes create a unique electrodeposition manner; i.e., Li metal homogenously deposits on the nanotubular wall, causing each Li nanotube to grow in circumference without obvious sign of dendritic formation. Thus, the full‐cell battery with the spaced Li nanotubes exhibits a high specific capacity of 132 mA h g−1 at 1 C and an excellent coulombic efficiency of ≈99.85% over 400 cycles.
Catalyst‐Free [3+2] Cycloaddition of Unactivated Imines with Cyclopropenones
Authors: Liu Si‐Wei , Yuan Chang , Jiang Xue‐Fei , Wang Xian‐Xun , Cui Hai‐Lei 
Published: November 2019

AbstractWe have developed a convenient and mild catalyst‐free synthesis of structurally diversified indolizinoindoles through [3+2] cycloaddition of dihydro‐β‐carbolines and diarylcyclopropenones. Dimethoxydihydroisoquinolines and 3,4‐dihydrobenzonaphthyridine can also be used in this process affording corresponding polycyclic N‐heterocycles with high molecular complexity.
Rapid and Efficient Construction of Indolizino[3,4,5‐ab]isoindole Skeletons by a Rhodium‐Catalyzed Tandem Reaction
Authors: Liu Chang , Wu Shaonan , Sun Wan , Meng Haifang , Xing Siyang , Zhu Bolin 
Published: November 2019

AbstractA facile rhodium‐catalyzed tandem reaction of two molecules of acrylates with two molecules of 2‐phenylpyridines involving sequential C−H activation, Michael addition, [12+2] cycloaddition and oxidative aromatization has been described. A series of indolizino[3,4,5‐ab]isoindole compounds were efficiently afforded in good yields by the formation of two C−C bonds, two C=C bonds and one C−N bond.
Development of a novel simulation‐based task trainer for management of retrobulbar hematoma
Authors: Chin Christopher J. , Clark Alexander , Roth Kathryn , Fung Kevin 
Published: November 2019

BackgroundRetrobulbar hematoma (RH) is a rare but devastating complication of sinus surgery. It is treated initially with a lateral canthotomy and cantholysis at the bedside. Due to the high stakes and urgency of this complication, teaching this in the clinical setting is difficult. The objective of this study was to develop a cadaveric model for addressing this problem.MethodsA fresh‐frozen human cadaveric model of RH was created using a Foley catheter to simulate elevated intraocular pressure. Residents who participated in an emergencies in otolaryngology–head & neck surgery “boot camp” were included in the study. A survey measuring confidence levels in performing lateral canthotomy and cantholysis was administered. After completing the skill station, a postintervention survey was administered to assess the confidence of the learner as well as fidelity and usefulness of the task trainer.ResultsThirty‐three residents participated in the boot camp. Residents rated their confidence preintervention at 1.3/5, which suggests the majority were unable to perform the procedure. After using the model, residents rated their confidence at 3.5/5, which falls between basic knowledge and reasonably confident; this improvement achieved statistical significance (p < 0.0001). The fidelity of the model was rated 3.9/5; a score of 4 is defined as realistic. The residents rated the usefulness of the model as 4.7; a score of 5 is defined as very useful.ConclusionA cadaveric model of RH was successfully developed. This novel simulator was perceived to be useful, realistic, and effective by junior residents.
[SnI8{Fe(CO)4}4]2+: eine hochkoordinierte Sn+III8‐Baueinheit mit fragilen Carbonylklammern
Authors: Wolf Silke , Köppe Ralf , Block Theresa , Pöttgen Rainer , Roesky Peter W. , Feldmann Claus 
Published: November 2019

Abstract[SnI8{Fe(CO)4}4][Al2Cl7]2 enthält ein [SnI8{Fe(CO)4}4]2+‐Kation mit einem beispiellos hochkoordinierten, zweifach überdachten SnI8‐Prisma. In Anbetracht der achtfachen Koordination mit dem voluminösesten, stabilen Halogenid ist es umso erstaunlicher, dass die SnI8‐Baugruppe nur von fragilen Fe(CO)4‐Gruppen klammerartig umgeben ist. Trotz der überwiegend ionischen Bindungssituation in [SnI8{Fe(CO)4}4]2+ sind die I−⋅⋅⋅I−‐Abstände verkleinert (bis zu 371 pm) und liegen deutlich unter dem Van‐der‐Waals‐Abstand (420 pm). Charakterisiert wurde die Titelverbindung durch Einkristallstrukturanalyse, spektroskopische Methoden (EDXS, FT‐IR, Raman, UV/Vis, Mößbauer), Thermogravimetrie und Dichtefunktionaltheorie.
Catalytic Production of Alanine from Waste Glycerol
Authors: Wang Yunzhu , Furukawa Shinya , Song Song , He Qian , Asakura Hiroyuki , Yan Ning 
Published: November 2019

AbstractChemical synthesis of amino acids directly from biomass feedstock is rare. Reported here is a one‐step protocol to convert crude glycerol, from the biodiesel industry, into 43 % alanine over a Ru1Ni7/MgO catalyst. The multifunctional catalytic system promotes glycerol conversion into lactic acid, and then into alanine. X‐ray absorption spectroscopy and scanning transmission electron microscopy revealed the existence of bimetallic RuNi species, whereas density‐functional theory calculations suggested Ni‐doped Ru substantially decreased the Ea of C−H bond dissociation of lactate alkoxide to form pyruvate, which is the rate‐determining step. The catalytic route established in this work creates new opportunities for glycerol utilization and enriches the substrate scope of renewable feedstock to access value‐added amino acids.
2D and 3D Porphyrinic Covalent Organic Frameworks: The Influence of Dimensionality on Functionality
Authors: Meng Yi , Luo Yi , Shi Ji‐Long , Ding Huimin , Lang Xianjun , Chen Wei , Zheng Anmin , Sun Junliang , Wang Cheng 
Published: November 2019

AbstractThe construction of 2D and 3D covalent organic frameworks (COFs) from functional moieties for desired properties has gained much attention. However, the influence of COFs dimensionality on their functionalities, which can further assist in COF design, has never been explored. Now, by selecting designed precursors and topology diagrams, 2D and 3D porphyrinic COFs (2D‐PdPor‐COF and 3D‐PdPor‐COF) are synthesized. By model building and Rietveld refinement of powder X‐ray diffraction, 2D‐PdPor‐COF crystallizes as 2D sheets while 3D‐PdPor‐COF adopts a five‐fold interpenetrated pts topology. Interestingly, compared with 2D‐PdPor‐COF, 3D‐PdPor‐COF showed interesting properties, including 1) higher CO2 adsorption capacity; 2) better photocatalytic performance; and 3) size‐selective photocatalysis. Based on this study, we believe that with the incorporation of functional moieties, the dimensionality of COFs can definitely influence their functionalities.
Heat‐Treated Aerogel as a Catalyst for the Oxygen Reduction Reaction
Authors: Zion Noam , Cullen David A. , Zelenay Piotr , Elbaz Lior 
Published: November 2019

AbstractAerogels are fascinating materials that can be used for a wide range of applications, one of which is electrocatalysis of the important oxygen reduction reaction. In their inorganic form, aerogels can have ultrahigh catalytic site density, high surface area, and tunable physical properties and chemical structures—important features in heterogeneous catalysis. Herein, we report on the synthesis and electrocatalytic properties of an iron–porphyrin aerogel. 5,10,15,20‐(Tetra‐4‐aminophenyl)porphyrin (H2TAPP) and FeII were used as building blocks of the aerogel, which was later heat‐treated at 600 °C to enhance electronic conductivity and catalytic activity, while preserving its macrostructure. The resulting material has a very high concentration of atomically dispersed catalytic sites (9.7×1020 sites g−1) capable of catalyzing the oxygen reduction reaction in alkaline solution (Eonset=0.92 V vs. RHE, TOF=0.25 e− site−1 s−1 at 0.80 V vs. RHE).
Efficient Nondoped Pure Blue Organic Light‐Emitting Diodes Based on an Anthracene and 9,9‐Diphenyl‐9,10‐dihydroacridine Derivative
Authors: He Xin , Ren Shenghong , Liu Hui , Zhao Shiyuan , Liu Futong , Du Chunya , Min Jiarui , Zhang Haiquan , Lu Ping 
Published: November 2019

AbstractOrganic light‐emitting diodes (OLEDs) have been greatly developed in recent years owing to their abundant advantages for full‐color displays and general‐purpose lightings. Blue emitters not only provide one of the primary colors of the RGB (red, green and blue) display system to reduce the power consumption of OLEDs, but are able able to generate light of all colors, including blue, green, red, and white by energy transfer processes in devices. However, it remains a challenge to achieve high‐performance blue electroluminescence, especially for nondoped devices. In this paper, we report a blue light emitting molecule, DPAC‐AnPCN, which consists of 9,9‐diphenyl‐9,10‐dihydroacridine and p‐benzonitrile substituted anthracene moieties. The asymmetrically decoration on anthracene with different groups on its 9 and 10 positions combines the merits of the respective constructing units and endows DPAC‐AnPCN with pure blue emission, high solid‐state efficiency, good thermal stability and appropriate HOMO and LUMO energy levels. Furthermore, DPAC‐AnPCN can be applied in a nondoped device to effectively reduce the fabrication complexity and cost. The nondoped device exhibits pure blue electroluminescence (EL) locating at 464 nm with CIE coordinates of (0.15, 0.15). Moreover, it maintains high efficiency at relatively high luminescence. The maximum external quantum efficiency (EQE) reaches 6.04 % and still remains 5.31 % at the luminance of 1000 cd m−2 showing a very small efficiency roll‐off.
Use of artificial nutrition near the end of life: Results from a French national population‐based study of hospitalized cancer patients
Authors: Baumstarck Karine , Boyer Laurent , Pauly Vanessa , Orleans Veronica , Marin Anthony , Fond Guillaume , Morin Lucas , Auquier Pascal , Salas Sébastien 
Published: November 2019

AbstractBackgroundThe use of artificial nutrition, defined as a medical treatment that allows a non‐oral mechanical feeding, for cancer patients with limited life expectancy is deemed nonbeneficial. High‐quality evidence about the use of artificial nutrition near the end of life is lacking. This study aimed (a) to quantify the use of artificial nutrition near the end‐of‐life, and (b) to identify the factors associated with the use of artificial nutrition.MethodsThis was a retrospective cohort study of decedents based on data from the French national hospital database. The study population included adult cancer patients who died in hospitals in France between 2013 and 2016 and defined to be in a palliative condition. Use of artificial nutrition during the last 7 days before death was the primary endpoint.ResultsA total of 398 822 patients were included. The median duration of the last hospital stay was 10 (interquartile range, 4‐21) days. The artificial nutrition was used for 11 723 (2.9%) during the last 7 days before death. Being a man, younger, having digestive cancers, metastasis, comorbidities, malnutrition, absence of dementia, and palliative care use were the main factors associated to the use of artificial nutrition.ConclusionThis study indicates that the use of artificial nutrition near the end of life is in keeping with current clinical guidelines. The identification of factors associated with the use of artificial nutrition, such as cancer localization, presence of comorbidities or specific symptoms, may help to better manage its use.
Development of a risk score for colorectal cancer in Chinese males: A prospective cohort study
Authors: Guo Lanwei , Chen Hongda , Wang Gang , Lyu Zhangyan , Feng Xiaoshuang , Wei Luopei , Li Xin , Wen Yan , Lu Ming , Chen Yuheng , Shi Jufang , Ren Jiansong , Lin Chunqing , Yu Xinyang , Chen Shuohua , Wu Shouling , Li Ni , Dai Min , He Jie 
Published: November 2019

AbstractTo build a simple predictive model as a guide to stratify average‐risk population for colonoscopy examinations. We collected data from 92 923 males without a prior history of cancer enrolled in the Kailuan Cohort Study of China. Risk factors included in the evaluation of colorectal cancer (CRC) were collected by questionnaire‐based interviews at the baseline. Logistic regression coefficients for incident CRC predictors were converted into risk scores by the absolute value of the smallest coefficient in the model and rounding up to the nearest integer. Receiver operating characteristic (ROC) analysis with the leave‐one‐out cross‐validation method was applied to evaluate model performance. In the 10‐year follow‐up, 353 CRC patients were in the cohort. Age, alcohol consumption, waist circumference, occupational sitting time, and history of diabetes were selected for the scoring system, and the adjusted area under the ROC was 0.66. Population in the highest risk group (16‐19 points) had a 33.12‐fold (95% CI: 13.44‐81.59) higher risk of CRC than those in the lowest risk group. When we defined 13 points as the cut‐off, the sensitivity and specificity of the scoring system for CRC were 67.99% and 62.42%, respectively. A simple scoring system for CRC has been developed to identify men at an increased relative risk of CRC within 10 years using several well‐established risk factors, which allows selection of asymptomatic candidates for priority of CRC screening and saving the health resource in cancer prevention and control.