bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restaging Patients with Rectal Cancer Following Neoadjuvant Chemoradiation: A Systematic Review
Authors: Hendrick Leah E. , Levesque Renee L. , Hinkle Nathan M. , Monroe Justin J. , Glazer Evan S. , Deneve Jeremiah L. , Yakoub Danny , Shibata David , Dickson Paxton V. 
Published: December 2019

AbstractBackgroundIn the USA, most patients with clinical stage II/III rectal cancer receive neoadjuvant chemoradiation (chemo/XRT) over 5–6 weeks followed by a 6–10‐week break before proctectomy. As chemotherapy is delivered at radio‐sensitizing doses, there is essentially a 3‐month window during which potential systemic disease is untreated. Evidence regarding the utility of restaging patients prior to proctectomy is limited.MethodsPubMed, Scopus, Web of Science, and the Cochrane Library were searched for studies evaluating the utility of restaging patients with rectal cancer after completion of long‐course chemo/XRT, and reporting associated changes in management. Studies that were non‐English, included <50 patients, or examining the diagnostic accuracy of imaging modalities were excluded. Study quality was evaluated using the modified Newcastle Ottawa Scale.ResultsEight studies were identified including a total of 1251 patients restaged between completion of chemo/XRT and proctectomy. All studies were retrospective. Restaging identified new metastatic disease in 72 (6.0%) patients, with 4 studies reporting specific sites: liver (n = 28), lung (n = 8), adrenal (n = 1), bone (n = 1), and multiple sites (n = 7). Overall progression (distant or local) was detected in 88 (7.0%) patients and resulted in a change in management in 77 (87.5%) of these patients. Tumor‐related prognostic characteristics were inconsistently reported among studies, precluding meta‐analysis.ConclusionsAlthough restaging between completion of neoadjuvant chemo/XRT and proctectomy detects disease progression in only a small percentage of patients, findings alter the treatment plan in the vast majority of these patients. Multi‐institutional collaboration with analysis of well‐defined prognostic variables may better identify patients most likely to benefit from restaging.
Backpack-mounted satellite transmitters do not affect reproductive performance in a migratory bustard
Authors: Burnside Robert J. , Guilherme João L. , Collar Nigel J. , Dolman Paul M. 
Published: December 2019

AbstractBackpack-mounted satellite transmitters (PTTs) are used extensively in the study of avian habitat use and of the movements and demography of medium- to large-bodied species, but can affect individuals’ performance and fitness. Transparent assessment of potential transmitter effects is important for both ethical accountability and confidence in, or adjustment to, life history parameter estimates. We assessed the influence of transmitters on seven reproductive parameters in Asian houbara Chlamydotis macqueenii, comparing 114 nests of 38 females carrying PTTs to 184 nests of untagged birds (non-PTT) over seven breeding seasons (2012–2018) in Uzbekistan. There was no evidence of any influence of PTTs on: lay date (non-PTT x̅ = 91.7 Julian day ± 12.3 SD; PTT x̅ = 95.1 Julian day ± 15.7 SD); clutch size (non-PTT x̅= 3.30 ± 0.68 SD; PTT x̅ = 3.25 ± 0.65 SD); mean egg weight at laying (non-PTT x̅ = 66.1 g ± 5.4 SD; PTT x̅ = 66.4 g ± 5.4 SD); nest success (non-PTT x̅ = 57.08% ± 4.3 SE; PTT x̅ = 58.24% ± 4.5 SE for nests started 2 April); egg hatchability (non-PTT x̅ = 88.3% ± 2.2 SE; PTT x̅ = 88.3% ± 2.6 SE); or chick survival to fledging from broods that had at least one surviving chick (non-PTT x̅ = 63.4% ± 4.2 SE; PTT x̅ = 64.4% ± 4.7 SE). High nesting propensity (97.3% year−1 ± 1.9% SE) of tagged birds indicated minimal PTT effect on breeding probability. These findings show that harness-mounted transmitters can give unbiased measures of demographic parameters of this species, and are relevant to other large-bodied, cursorial, ground-nesting birds of open habitats, particularly other bustards.
Analysis on discharge behavior and performance of As- and B-doped silicon anodes in non-aqueous Si–air batteries under pulsed discharge operation
Authors: Durmus Yasin Emre , Roitzheim Christoph , Tempel Hermann , Hausen Florian , Ein-Eli Yair , Kungl Hans , Eichel Rüdiger-A. 
Published: December 2019

AbstractVery high theoretical specific energies and abundant resource availability have emerged interest in primary Si–air batteries during the last decade. When operated with highly doped Si anodes and EMIm(HF)2.3F ionic liquid electrolyte, specific energies up to 1660 Wh kgSi−1can be realized. Owing to their high-discharge voltage, the most investigated anode materials are$$\langle 100\rangle$$⟨100⟩oriented highly As-doped Si wafers. As there is substantial OCV corrosion for these anodes, the most favorable mode of operation is continuous discharge. The objective of the present work is, therefore, to investigate the discharge behavior of cells with$$\langle 100\rangle$$⟨100⟩As-doped Si anodes and to compare their performance to cells with$$\langle 100\rangle$$⟨100⟩B-doped Si anodes under pulsed discharge conditions with current densities of 0.1 and 0.3 mA cm−2. Nine cells for both anode materials were operated for 200 h each, whereby current pulse time related to total operating time ranging from zero (OCV) to one (continuous discharge), are considered. The corrosion and discharge behavior of the cells were analyzed and anode surface morphologies after discharge were characterized. The performance is evaluated in terms of specific energy, specific capacity, and anode mass conversion efficiency. While for high-current pulse time fractions, the specific energies are higher for cells with As-doped Si anodes, along with low-current pulse fractions the cells with B-doped Si anodes are more favorable. It is demonstrated, that calculations for the specific energy under pulsed discharge conditions based on only two measurements—the OCV and the continuous discharge—match very well with the experimental data.Graphic abstract
Mutation-specific differences in arrhythmias and drug responses in CPVT patients: simultaneous patch clamp and video imaging of iPSC derived cardiomyocytes
Authors: Pölönen R. P. , Swan H. , Aalto-Setälä K. 
Published: December 2019

AbstractCatecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac disease characterized by arrhythmias under adrenergic stress. Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for CPVT. We characterized electrophysiological properties of CPVT patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) carrying different mutations in RYR2 and evaluated effects of carvedilol and flecainide on action potential (AP) and contractile properties of hiPSC-CMs. iPSC-CMs were generated from skin biopsies of CPVT patients carrying exon 3 deletion (E3D) and L4115F mutation in RYR2. APs and contractile movement were recorded simultaneously from the same hiPSC-CMs. Differences in AP properties of ventricular like CMs were seen in CPVT and control CMs: APD90 of both E3D (n = 20) and L4115F (n = 25) CPVT CMs was shorter than in control CMs (n = 15). E3D-CPVT CMs had shortest AP duration, lowest AP amplitude, upstroke velocity and more depolarized diastolic potential than controls. Adrenaline had positive and carvedilol and flecainide negative chronotropic effect in all hiPSC CMs. CPVT CMs had increased amount of delayed after depolarizations (DADs) and early after depolarizations (EADs) after adrenaline exposure. E3D CPVT CMs had the most DADs, EADs, and tachyarrhythmia. Discordant negatively coupled alternans was seen in L4115F CPVT CMs. Carvedilol cured almost all arrhythmias in L4115F CPVT CMs. Both drugs decreased contraction amplitude in all hiPSC CMs. E3D CPVT CMs have electrophysiological properties, which render them more prone to arrhythmias. iPSC-CMs provide a unique platform for disease modeling and drug screening for CPVT. Combining electrophysiological measurements, we can gain deeper insight into mechanisms of arrhythmias.
The changing form of overconfidence and its effect on growth expectations at the early stages of startups
Authors: Szerb László , Vörös Zsófia 
Published: December 2019

AbstractIn this article, we attempt to explain the failure of many studies to show a link between entrepreneurs’ beliefs in their entrepreneurial skills and the actual or expected growth of their venture. By using Frese and Gielnik’s action-characteristics model of entrepreneurship as an analytical framework and analyzing Global Entrepreneurship Monitor Adult Population Survey data, we show that entrepreneurs’ perceived entrepreneurial skills are consistently inflated over the different phases of the startup, albeit in different ways. Depending on the typical form of overconfidence, the link between skill beliefs and growth expectations may be mediated by expectations about competitive advantages. Moreover, the huge drop in growth expectations is not associated with a drop in perceived skills; instead other entrepreneurial expectations also become more realistic and their effect strengthens with experience.
Thermal baths as sources of pharmaceutical and illicit drug contamination
Authors: Jakab Gergely , Szalai Zoltán , Michalkó Gábor , Ringer Marianna , Filep Tibor , Szabó Lili , Maász Gábor , Pirger Zsolt , Ferincz Árpád , Staszny Ádám , Dobosy Péter , Kondor Attila Csaba 
Published: December 2019

AbstractDespite the fact that there are tens of thousands of thermal baths in existence, knowledge about the occurrence of pharmaceutically active compounds (PhACs) in untreated thermal wastewater is very limited. Because used thermal water is typically legally discharged into surface waters without any treatment, the effluent poses environmental risks for the receiving water bodies. The aim of this study was to show the occurrence patterns and spatiotemporal characteristics of 111 PhACs in thermal wastewater. Six thermal water outflows of different thermal baths were tested in different seasons in the Budapest metropolitan region (Hungary), and diurnal analysis was performed. After solid-phase extraction, the samples were analysed and quantified by coupling supercritical fluid chromatography and mass spectrometry to perform simultaneous multi-residue drug analysis. The results confirm that water discharge pipes directly transport pharmaceuticals into surface water bodies; 34 PhACs were measured to be over the limit of quantification at least once, and 21 of them were found in more than one water sample. The local anaesthetic drug lidocaine, antiepileptic carbamazepine, analgesic derivative tramadol and illicit drug cocaine were detected in more than half of the samples. Caffeine, metoprolol and bisoprolol (cardiovascular drugs), benzoylecgonine (cocaine metabolite), diclofenac (NSAID), citalopram (antidepressant) and certain types of hormones also have a significant frequency of 30-50%. However, the occurrence and concentrations of PhACs vary according to the season and number/types of visitors. As demonstrated by the diurnal fluctuation, drug contamination of thermal waters can significantly vary, even for similar types of baths; furthermore, the quantity and types of some pollutants rapidly change in the discharged thermal wastewater.
Interventionen am diabetischen Herzen
Authors: Zweiker Robert , Zirlik Andreas , Scherr Daniel 
Published: December 2019

ZusammenfassungWeltweit steigen die Raten an Diabetes und damit der diesem inhärenten kardiovaskulären Erkrankungen deutlich an. Initiation, Progression und Komplikationen beider Erkrankungen sind wesentlich durch immunologische und inflammatorische Mechanismen determiniert und damit pathophysiologisch eng miteinander verbunden. Ausführlich werden die jeweils unterschiedlichen Therapiemöglichkeiten sowohl im Hinblick auf die koronare Herzerkrankung als auch bezüglich Herzrhythmusstörungen dargestellt. Dabei werden die aktuell für den Diabetespatienten geltenden Behandlungsempfehlungen und Leitlinien praktisch erörtert und konsequent wesentliche klinische Fragen beantwortet, z. B. hinsichtlich der kardiovaskulären Risikostratifizierung bei Diabetes, der interventionellen vs. operativen Versorgung von Patienten mit koronarer Herzerkrankung und Diabetes, der Behandlung von Patienten mit Diabetes und akutem Koronarsyndrom sowie der Prävalenz und Inzidenz von Vorhofflimmern bei Diabetespatienten.
Adaptive multi-parameter regularization approach to construct the distribution function of relaxation times
Authors: Žic Mark , Pereverzyev Sergiy , Subotić Vanja , Pereverzyev Sergei 
Published: December 2019

AbstractDetermination of the distribution function of relaxation times (DFRT) is an approach that gives us more detailed insight into system processes, which are not observable by simple electrochemical impedance spectroscopy (EIS) measurements. DFRT maps EIS data into a function containing the timescale characteristics of the system under consideration. The extraction of such characteristics from noisy EIS measurements can be described by Fredholm integral equation of the first kind that is known to be ill-posed and can be treated only with regularization techniques. Moreover, since only a finite number of EIS data may actually be obtained, the above-mentioned equation appears as after application of a collocation method that needs to be combined with the regularization. In the present study, we discuss how a regularized collocation of DFRT problem can be implemented such that all appearing quantities allow symbolic computations as sums of table integrals. The proposed implementation of the regularized collocation is treated as a multi-parameter regularization. Another contribution of the present work is the adjustment of the previously proposed multiple parameter choice strategy to the context of DFRT problem. The resulting strategy is based on the aggregation of all computed regularized approximants, and can be in principle used in synergy with other methods for solving DFRT problem. We also report the results from the experiments that apply the synthetic data showing that the proposed technique successfully reproduced known exact DFRT. The data obtained by our techniques is also compared to data obtained by well-known DFRT software (DRTtools).
Flood vulnerability mapping using frequency ratio (FR) model: a case study on Kulik river basin, Indo-Bangladesh Barind region
Authors: Sarkar Debabrata , Mondal Prolay 
Published: December 2019

AbstractFlood is a natural but inevitable phenomenon occurring over the period of time. It not only damages the life, property and resources, but also hampers the economy of a nation. In this paper, an attempt has been made to delineate flood vulnerability areas for Kulik river basin through frequency ratio model. Parameters like slope, elevation, rainfall, drainage density, land use–land cover, TWI, population density, road density and household density were endorsed for understanding flood mechanism. In general, 70 (70%) flood locations from flood inventory map were randomly selected for constructing flood vulnerability map parameters and the rest 30 (30%) flood locations were used for justifying the outcomes. Flood vulnerability zone map was classified into five zones such as very low (2.02 km2), low (2.45 km2), moderately low (2.44 km2), high vulnerable (2.26 km2) and very high vulnerable (1.21 km2) area. As the AUC value for success rate is 0.901, the constructed flood vulnerable map with FR model is very much accurate for this river basin. The outcome of this paper will help the planners and decision-makers to take some probable measure to minimize flood vulnerability in this region.
Rapid screening of oil-rim reservoirs for development and management
Authors: Lawal Kazeem A. , Yadua Asekhame U. , Ovuru Mathilda I. , Okoh Oluchukwu M. , Eyitayo Stella I. , Matemilola Saka , Olamigoke Olugbenga 
Published: December 2019

AbstractAs an improvement over existing screening techniques, we introduce the relative mobile energy of primary gas-cap to the aquifer (Egw) as a new parameter for characterizing the performance of oil-rim reservoirs. Egw integrates key static and dynamic reservoir properties. To account for the time value of production, the framework allows maximizing the discounted recovery factor (DRF) of oil, gas or total hydrocarbon as the objective function. Employing detailed simulations of different well-defined oil-rim models, DRFs of oil, gas and total hydrocarbons have been correlated against Egw for common development concepts and well types. These correlations have resulted in a new screening technique for both green and brown oil-rim reservoirs. In addition to presenting simple generic charts for quick evaluation of oil-rim reservoirs, the main contributions of this work include the introduction of Egw as a new performance-characterizing parameter, and the flexibility to consider the DRF of any of oil, gas or total hydrocarbon as the basis for screening an oil-rim reservoir for development planning and field management. Using the example of a brown oil-rim reservoir, the applicability and robustness of the new screening technique are demonstrated.
Treatment of drill cuttings using microemulsion
Authors: Dantas Tereza Neuma de Castro , da Silva Daniel Nobre Nunes , Dantas Neto Afonso Avelino , Cabral Tycianne Janynne de Oliveira , dos Anjos Aécia Seleide Dantas 
Published: December 2019

AbstractConventional treatment of drill cuttings, as drying and thermal desorption, is failing to meet environmental and economic standards; therefore, new alternatives for the treatment of this waste must be developed. The purpose of this study was to remove n-paraffin from drill cuttings using microemulsion systems (MES). The extraction percentage (%) of n-paraffin was quantified by gas chromatography with a flame ionization detector. The optimization of extraction parameters showed that the extraction percentage (%) is directly proportional to the stirring speed and contact time and inversely proportional to the HLB of the surfactant used in the microemulsion system. Results for MES using Alkonat® L90 and Renex® 95 were similar, but Alkonat® L90 was chosen as the best system considering the environmental issue. The MES/cuttings ratio did not influence the percentage of n-paraffin extracted, reaching 55.03% and 56.32% for the ratios of 0.5 and 2.0, respectively. The reuse of MES in multiple extractions showed that MES can be reused in up to two extractions, obtaining up to 86% extraction. The optimal parameters for Alkonat® L90 microemulsion systems were MES/cuttings ratio of 1.0, stirring speed of 132 strokes, and contact time of 80 min, achieving 86.27% extraction. Results obtained in this study may help to better understand n-paraffin removal from drill cuttings by MES, considering the future use of this technology in the design of an industrial treatment plant for both onshore and offshore operations.
Safety and probiotic functionality of isolated goat milk lactic acid bacteria
Authors: da Silva Liliane Andrade , Lopes Neto Jose Honorio Pereira , Cardarelli Haíssa Roberta 
Published: December 2019

Abstract
Purpose
Lactic acid bacteria (LAB) are traditionally employed in the food industry. LAB strains from goat milk may also present probiotic potential, and it is fundamental to study the safety and functionality aspects which are desirable for their use in food. The objective of this study was to verify the probiotic potential of lactic bacteria isolated from goat milk.

Methods
The presence of safety-related virulence factors (hemolytic activity, gelatinase production, coagulase, and sensitivity to antibiotics) as well as functionality (exopolysaccharide (EPS) production, proteolytic activity, autoaggregation, gas production, survival in the gastrointestinal tract, and antimicrobial activity against bacteria that impair oral health) were determined.

Result
The selected LAB strains are safe against the evaluated parameters and have characteristics of possible probiotic candidates. Especially L. plantarum (DF60Mi) and Lactococcus lactis (DF04Mi) have potential to be added to foods because they have better resistance to simulated gastrointestinal conditions. In addition, they are isolated with already proven antimicrobial activity against Listeria monocytogenes, an important food-borne pathogen. DF60Mi was able to produce EPS (exopolysaccharides). LS2 and DF4Mi strains, both Lactococcus lactis subsp. lactis, demonstrated antimicrobial activity against S. mutans ATCC 25175, a recurrent microorganism in oral pathologies, mainly caries.

Conclusion
This study provides subsidies for future exploration of the potentialities of these LAB strains for both the development of new functional foods and for application in oral health.
Outcomes of honeybee pupae inoculated with deformed wing virus genotypes A and B
Authors: Dubois Eric , Dardouri Marine , Schurr Frank , Cougoule Nicolas , Sircoulomb Fabrice , Thiéry Richard 
Published: December 2019

AbstractDeformed wing virus and Varroa destructor virus-1 have a high percentage of nucleotide identity and might be considered as closely related viruses: DWV genotype A (DWV-A) and DWV genotype B (DWV-B) respectively. They have been implicated in overwinter colony losses in association with Varroa destructor infestations that vectored both DWV variants. In this study, we performed experimental inoculations of honeybee pupae with viral suspensions prepared from honeybee heads naturally infected by either DWV-A or DWV-B. Two outcomes were observed: the inoculated pupae exhibited either higher rates of bees with deformed wings or higher mortality rates than control bees. For both DWV variants, the viral loads quantified in the head of inoculated bees were significantly greater than those in control bees (p < 0.01). These outcomes were not correlated to the virus genotype (DWV-A or DWV-B) detected in the inocula by RT-quantitative PCR targeting the VP3 coding sequence (RT-qPCR). However, the highest mortality rates found in our study were correlated with an increase in sacbrood virus (SBV) load. Despite the fact that only either DWV-A or DWV-B was expected to be inoculated, we observed increased mortality in honeybees that were infected with both DWV and SBV.
Physico-chemical and microbiological quality of M’Zar wastewater treatment plant effluents and their impact on the green irrigation of the Golf course
Authors: Chahouri Abir , Ouahmani Nadia El , Choukrallah Redouane , Yacoubi Bouchra 
Published: December 2019

Abstract
Purpose
Reuse of treated wastewater (TWW) for irrigation can be an effective strategy in Morocco to overcome the pressure on freshwater resources. The M’zar wastewater plant is based on percolation infiltration treatment, allowing the purification of the wastewater of Agadir, and with its UV disinfection system, it is now possible to reuse this water for irrigation. In this sense, the aim of our study is to evaluate the microbiological and physicochemical quality of the treated wastewater of this station, used for irrigation of a Golf course as well as to determine its impact on grass and soil.

Methods
A monitoring of TWW quality was carried out monthly on the level of the Ocean’s Golf on water samples, grass and soil. This monitoring is related to the physicochemical (pH, temperature, conductivity, STD, COD, and BOD5) and bacteriological characteristics by counting the indicators of faecal contamination, faecal coliforms (FC), faecal streptococci (FS), Salmonella and Vibrios as well as sulphito-reducers spores (SRS).

Results
The results of microbiological analysis in the three compartments confirm the presence of various organisms such as FC, FS, and SRS in a very significant number with no load in Salmonella and Vibrios during our study period. For physicochemical analyses, we observed that only the conductivity showed fairly a high value of 6.38 dS/m.

Conclusion
The obtained physicochemical and bacteriological results revealed that the treated wastewater with the M’zar plant complies with national and international standards.