bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of sensory effects of thiols in red wines by projective mapping using multifactorial analysis and correspondence analysis
Authors: Garrido‐Bañuelos Gonzalo , Panzeri Valeria , Brand Jeanne , Buica Astrid 
Published: May 2020

AbstractThe aim of the current study was to systematically evaluate effects of single thiols, of thiol interactions in a single red wine matrix, and of red wine matrix effects combined with thiol interactions using projective mapping (PM) with experienced assessors. All work was done in dearomatized red wine from various cultivars. A dual approach to the projective mapping data analysis (coordinates and multifactorial analysis or frequency of citations and correspondence analysis), coupled to regression vector (RV) coefficients allowed to test the hypothesis that the resulting maps should be similar, which was the case for single thiols (RV > 0.7) but not for the more complex thiol × thiol or thiol × thiol × matrix interactions tested (RV < 0.7). It was shown that 4‐mercapto‐4‐methylpentan‐2‐one (4MMP) levels were relatively more important than the cultivar used, while the opposite was true for 3‐mercapto‐1‐hexanol (3MH) and 3‐mercaptohexyl acetate (3MHA). No specific descriptors were associated with 3MH and 3MHA, but the wines had more “savory” notes. The interaction effects of 3MH × 4MMP and 3MHA × 4MMP were different both in the number and in the frequency of citation of the attributes.Practical ApplicationsComplex multilevel sensory interaction phenomena can be studied if a pragmatic and systematic practical methodology is used, as demonstrated by this work. As the method used does not require a trained panel, this type of approach can be used also outside an academic environment, to the benefit of the industry; however, the researchers must take into account the complexity of the matrix and the difficulty of the assessment. The outcome of the dual approach to the data analysis could help researchers decide which data handling option is better suited for their work.
Cassia tora extract alleviates Aβ1–42 aggregation processes in vitro and protects against aluminium-induced neurodegeneration in rats
Authors: Ravi Sunil K , Narasingappa Ramesh B , Mundagaru Ravi , Girish Talakatta K , Vincent Bruno 
Published: May 2020

Abstract

Objectives
To examine the ability of Cassia tora extract to produce, in vitro and in vivo, beneficial effects with respect to events occurring during Alzheimer's disease.

Methods
Previously characterised methanol extract of C. tora was tested for its ability to lessen Aβ42 aggregation processes in vitro and to alleviate aluminium-induced impairments in vivo in rats.

Key findings
Cassia tora extract prevents the aggregation of monomeric, oligomeric and fibrillary Aβ1–42 in vitro. Moreover, the daily ingestion of 100 and 400 milligrams of the extract per kilogram of body weight for 60 days ameliorates the neurobehavioral and cognitive abilities of aluminium-treated rats in vivo. Importantly, treatments with the extract trigger a significant recovery of antioxidant enzymes function, a diminution of lipid peroxidation and acetylcholinesterase activity, a decrease of pro-inflammatory cytokines expression and an increase of brain-derived neurotrophic factor levels in both the hippocampus and the frontal cortex. Finally, we evidence that the extract is able to ameliorate the aluminium-dependent loss of neuronal integrity in the CA1 and CA3 regions of the hippocampus.

Conclusions
Altogether, our results reveal that methanol extract of C. tora is able to prevent typical AD-related events and therefore stands as a promising mild and natural anti-AD multitarget compound.
A comparative study on pharmacokinetics and tissue distribution of 5-hydroxy-4-methoxycanthin-6-one and its metabolite in normal and dextran sodium sulfate-induced colitis rats by HPLC-MS/MS
Authors: Liu Fangle , Zhang Qiuyu , Lin Chaozhan , Yao Yufeng , Wang Meiqi , Liu Changhui , Zhu Chenchen 
Published: May 2020

Abstract

Objectives
This study aimed to investigate the existing form of 5-hydroxy-4-methoxycanthin-6-one (PQ-A) in vivo after oral administration and the effects on its pharmacokinetics and tissue distribution by colitis.

Methods
A rapid HPLC-MS/MS method was established to simultaneously determine PQ-A and its main metabolite, 1-methoxicabony-β-carboline (PQ-B), in biological samples acquired from normal and dextran sodium sulfate (DSS)-induced colitic rats administered orally with PQ-A. Then, the pharmacokinetics of both PQ-A and PQ-B, and tissue distribution of PQ-A in the above two states were analysed.

Key findings
The pharmacokinetic results showed that the prototype of PQ-A was the main existing form in both physiological and pathological conditions. And significant difference between the above two status in pharmacokinetics of PQ-A was observed, such as higher exposure and longer elimination in colitis than that in normal rats. It suggested that the pharmacokinetics of medications for colitis was affected by enteritis. The tissue distribution studies displayed that PQ-A mainly accumulated in intestinal tract. Especially, the distribution of PQ-A in intestinal tract was increased obviously in colitic rats.

Conclusions
These results contributed to further illuminate the ADME process of PQ-A in different status and were prospected to be the reference to the clinical application of similar medicines in pathological states.
Effects of a Reading Intervention Implemented at Differing Intensities for Upper Elementary Students
Authors: Donegan Rachel E. , Wanzek Jeanne , Al Otaiba Stephanie 
Published: May 2020

AbstractStudents with disabilities who display severe reading difficulties may require intensive interventions in order to make progress. The purpose of this study is to examine the effects of a multicomponent reading intervention implemented at two different intensities, in two separate randomized control trials, for a subset of fourth‐grade students who displayed severe reading difficulties, and who had or were at risk for disabilities. We use multilevel models to examine the effect of a standard, less intensive implementation in Study 1, and of a more intensive implementation in Study 2, relative to typical school services. Analyses revealed no significant effects of treatment for the standard, less intensive implementation in Study 1. Significant effects for word reading and word reading fluency outcomes for students assigned to receive the intensive implementation were noted in Study 2. Implications, limitations, and directions for future research are discussed.
Decline of zooplankton food resources of Limnothrissa miodon fishery in Lake Kariba: Global warming‐induced ecosystem disruption by Cylindrospermopsis raciborskii
Authors: Magadza Christopher H. D. , Madzivanzira Takudzwa C. , Chifamba Portia C. 
Published: May 2020

AbstractThe present study was conducted on the Lake Kariba portion of the Middle Zambezi Biosphere Reserve. Magadza (2011) previously reported the pelagic Lake Tanganyika sardine (Limnothrissa miodon) fishery introduced into Lake Kariba was declining. This phenomenon was attributed to observed climate‐change‐related warming of the lake, facilitating establishment of the invasive Cylindrospermopsis raciborskii, currently the dominant alga in the lake. Chlorophyceae contribute to less than 10% of the phytoplankton biomass. Accordingly, it was postulated that its dominance in the lake resulted in a food chain disruption because this cyanobacterium was not preferred by zooplankton grazers. Accordingly, the present study examined the feeding behaviour of L miodon with reference to available food items in the Sanyati Basin of Lake Kariba. The results highlighted a virtual absence of entomostraca zooplankton in the Sanyati Basin of Lake Kariba, in contrast to previous findings of previous studies, the avoidance of C. raciborskii in the diet of L. miodon, as measured by the Ivlev electivity index, a low stomach fullness index, the movement of L. miodon to macroinvertebrates associated with the littoral zone as a food source, and unfavourable dietary indicators of L. miodon. These results collectively suggest a food deficit for L. miodon in Lake Kariba, leading to the previously observed decline in the lake fishery.
Social cognitive intervention following an initial implantable cardioverter defibrillator: Better treatment response for secondary versus primary prevention
Authors: Auld Jonathan P. , Thompson Elaine A. , Dougherty Cynthia M. 
Published: May 2020

AbstractBackgroundThe patient + partner (P+P) is a patient/partner‐focused social cognitive intervention with demonstrated efficacy to improve outcomes following an initial implantable cardioverter defibrillator (ICD). Little is known about how the patient response may differ by ICD implant indication. The aim of this study was to examine the response to intervention for patients with an initial ICD by reasons for primary versus secondary ICD indication.MethodA longitudinal secondary analysis of data from a randomized clinical trial testing the P+P intervention examined patient health outcomes over 12 months, stratified by the indication for the ICD: primary prevention without cardiac resynchronization therapy (CRT) (1o No CRT, n = 100), primary prevention with CRT (1o CRT, n = 78), secondary prevention after cardiac arrest (2° Cardiac Arrest, n = 66), and secondary prevention for other arrhythmias (2o Other, n = 57). Outcomes included physical and mental health status (Short‐Form‐36 Physical Component Summary and Mental Component Summary), physical symptoms (Patient Concerns Assessment), depression (Patient‐Health‐Questionniare‐9), and anxiety (State‐Trait Anxiety Inventory).ResultsParticipants (n = 301) were on average 64 years old, primarily male (73.7%) and Caucasian (91%) with reduced ejection fraction (34%). There were no baseline differences between ICD groups for all outcomes (P > .05). Patients in the 2° Cardiac Arrest group showed greater improvement from baseline to 3 months in physical and mental health outcomes. The 2° Cardiac Arrest group had better physical (F = 11.48, P = .004) and mental health (F = 4.34, P = .038) and less severe physical (z = 2.24, P = 0.013) and depressive symptoms (z = 2.71, P = .003) at 12 months compared to the 1o No CRT group.ConclusionThe P+P intervention was more effective for promoting physical and psychological health outcomes for individuals receiving an ICD for 2o prevention after cardiac arrest.
Pulmonary alveolar proteinosis
Authors: Jouneau Stéphane , Ménard Cédric , Lederlin Mathieu 
Published: May 2020

ABSTRACTPAP is an ultra‐rare disease in which surfactant components, that impair gas exchange, accumulate in the alveolae. There are three types of PAP. The most frequent form, primary PAP, includes autoimmune PAP which accounts for over 90% of all PAP, defined by the presence of circulating anti‐GM‐CSF antibodies. Secondary PAP is mainly due to haematological disease, infections or inhaling toxic substances, while genetic PAP affects almost exclusively children. PAP is suspected if investigation for ILD reveals a crazy‐paving pattern on chest CT scan, and is confirmed by a milky looking BAL that gives a positive PAS reaction indicating extracellular proteinaceous material. PAP is now rarely confirmed by surgical lung biopsy. WLL is still the first‐line treatment, with an inhaled GM‐CSF as second‐line treatment. Inhalation has been found to be better than subcutaneous injections. Other treatments, such as rituximab or plasmapheresis, seem to be less efficient or ineffective. The main complications of PAP are due to infections by standard pathogens (Streptococcus, Haemophilus and Enterobacteria) or opportunistic pathogens such as mycobacteria, Nocardia, Actinomyces, Aspergillus or Cryptococcus. The clinical course of PAP is unpredictable and spontaneous improvement can occur. The 5‐year actuarial survival rate is 95%.
Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell transplantation
Authors: Pérez Ariadna , Montoro Juan , Hernani Rafael , Lorenzo Ignacio , Hernández‐Boluda Juan Carlos , Giménez Estela , Gómez María Dolores , Balaguer‐Roselló Aitana , Gonzalez‐Barberá Eva , Guerreiro Manuel , Aguilar Cristóbal , Navarro David , Solano Carlos , Sanz Jaime , Piñana José Luis 
Published: May 2020

AbstractBackgroundEnterovirus/rhinoviruses (EvRh) are the most common cause of respiratory virus infections in recipients of allogeneic stem cell transplantation (allo‐HSCT).ObjectiveWe sought to analyze the value of the immunodeficiency scoring index (ISI) in predicting lower respiratory tract disease (LRTD) progression and mortality in a prospective cohort of consecutive adult (>16 years) allo‐HSCT recipients with EvRh infection from December 1 2013 to December 1 2019 at two Spanish transplant centers.ResultsWe included 234 allo‐HSCT recipients with 383 EvRh episodes. Out of 383 EvRh episodes, 98 (25%) had LRTD. Multivariate logistic regression analysis identified three independent factors associated with LRTD progression: Ig G < 400 mg/dL, community‐acquired respiratory virus (CARV) co‐infection and high‐risk ISI. Inclusion of Ig G levels and CARV co‐infection in the ISI improved its performance by significantly increasing the area under the receiver operator characteristic curve (AUROC) from 0.643 to 0.734 (P = .03). Likewise, the two conditions identified by multivariate analyses as associated with higher probability of mortality were high‐risk ISI and EvRh infection within 6 months after transplant.ConclusionsOur findings confirm the value of high‐risk ISI in predicting both probability of EvRh LRTD and 3‐month overall mortality. We also demonstrate that the original ISI could be adapted to other CARV types by including additional variables to improve its performance.
Nuclear import of LIKE HETEROCHROMATIN PROTEIN1 is redundantly mediated by importins α‐1, α‐2 and α‐3
Authors: Chen Chong , Kim Daewon , Yun Hee Rang , Lee Yun Mi , Yogendra Bordiya , Bo Zhao , Kim Hae Eun , Min Jun Hong , Lee Yong‐Suk , Rim Yeong Gil , Kim Hyun Uk , Sung Sibum , Heo Jae Bok 
Published: May 2020

SummaryLIKE HETEROCHROMATIN PROTEIN1 (LHP1) encodes the only plant homologue of the metazoan HETEROCHROMATIN PROTEIN1 (HP1) protein family. The LHP1 protein is necessary for proper epigenetic regulation of a range of developmental processes in plants. LHP1 is a transcriptional repressor of flowering‐related genes, such as FLOWERING LOCUS T (FT), FLOWERING LOCUS C (FLC), AGAMOUS (AG) and APETALA 3 (AP3). We found that LHP1 interacts with importin α‐1 (IMPα‐1), importin α‐2 (IMPα‐2) and importin α‐3 (IMPα‐3) both in vitro and in vivo. A genetic approach revealed that triple mutation of impα‐1, impα‐2 and impα‐3 resulted in Arabidopsis plants with a rapid flowering phenotype similar to that of plants with mutations in lhp1 due to the upregulation of FT expression. Nuclear targeting of LHP1 was severely impaired in the impα triple mutant, resulting in the de‐repression of LHP1 target genes AG, AP3 and SHATTERPROOF 1 as well as FT. Therefore, the importin proteins IMPα‐1, ‐2 and ‐3 are necessary for the nuclear import of LHP1.
Experimental Study of Refrigerant (R-134a) Condensation Heat Transfer and Retention Behavior on Paraffin-Coated Vertical Plates and Fin Structures
Authors: Jin Hong-Qing , Wang Sophie 
Published: May 2020

AbstractCondensation of refrigerant R-134a is experimentally investigated on a paraffin-coated copper surface and compared to condensation on a plain copper surface. Heat transfer and visualization experiments are conducted for vertical-plate samples and for two different fin structures at various degrees of subcooling. A one-dimensional heat conduction model is used to interpret the condensation heat transfer measurements, while liquid retention behavior is quantified with the aid of image processing. The experimental results on vertical plates show that the heat transfer is enhanced on the coated surface with a maximum increase of 27% in the condensing heat transfer coefficient. On fin structures, the liquid retention was reduced by up to 28% on a coated surface. The heat transfer and retention behavior vary with surface material, degree of subcooling, and fin geometry.
Multiproxy records in middle–late Miocene sediments from the Wushan Basin: Implications for climate change and tectonic deformation in the northeastern Tibetan Plateau
Authors: Wang Weitao , Zhang Peizhen , Wang Zhicai , Liu Kang , Xu Hongyan , Liu Caicai , Zhang Huiping , Zheng Wenjun , Zheng Dewen 
Published: May 2020

AbstractTo help understand the relationship between global cooling and Tibetan uplift in the middle to late Miocene, multiple proxy data including carbonate stable isotope records, magnetic susceptibility, and sediment color references were obtained from a magnetostratigraphic section (14.5–6.0 Ma) of the Wushan Basin along the northeastern margin of the Tibetan Plateau. New proxies identify two phase changes that may have been controlled by global cooling and tectonic deformation at this time. During 14.5–13.2 Ma, positive shifts of ∼2.0‰ in δ18O and δ13C, an increase in lightness (L*), and a decrease in redness (a*) suggest gradually increasing aridity. Relatively high δ18O and δ13C values and low a*/L* and magnetic susceptibility values continue until ca. 10 Ma, when δ18O and δ13C significantly decrease and redness as well as magnetic susceptibility significantly increase. The negative shifts in δ18O and δ13C and increases in redness and magnetic susceptibility at 10 Ma are consistent with coeval basin environment and provenance changes. Combining these data with basin analysis, we suggest that global cooling was the dominant factor and Tibetan uplift was the subordinate factor for the middle Miocene aridification of the Wushan Basin. In contrast, the contribution of Tibetan uplift was dominant and global climate change was subordinate in the late Miocene basin paleogeographic reorganization.
Association of illicit drug use in adolescence with socioeconomic and criminal justice outcomes in adulthood: prospective findings from a UK national birth cohort
Authors: White James , Bell Steven , Batty G David 
Published: May 2020

BackgroundIllicit drug use in adolescence has been linked to drug use and poor mental health in adult life, but few studies have examined the relation between adult economic and criminal justice outcomes.MethodsWe analysed data from 14 082 participants (6999 women) in the 1970 British Birth Cohort Study. Illicit drug use over study members’ lifetime and in the past year were self-reported at 16 years of age. Thirteen outcomes were self-reported at 30 years of age, including illicit drug use, smoking, problems with alcohol, mental and physical health, experience of socioeconomic disadvantage and experiences with the criminal justice system.ResultsAt 16 years of age, 20.3% of the participants had ever tried an illicit drug and 7.2% had used in the past year. After adjustment for ﻿childhood socioeconomic status and mental health problems, and following correction for multiple testing, there was a dose–response association between illicit drug use at 16 years with illicit drug use in adult life in the past year (OR; 95% CI – 1.83, 1.51 to 3.12), experiencing homelessness (1.74, 1.16 to 2.62), being arrested (1.57, 1.29 to 1.92) and cautioned (1.97, 1.50 to 2.57) by the police, and being found guilty at court (1.73, 1.34 to 2.23).ConclusionsAdolescent drug use was associated with an array of social and criminal outcomes in later life.
Recent total cross section measurements in electron scattering from molecules
Authors: Szmytkowski Czesław , Możejko Paweł 
Published: May 2020

Abstract

The grand-total cross sections (TCSs) for electron scattering from a range of molecules, measured over the period 2009–2019 in various laboratories, with the use of different electron transmission systems, are reviewed. Where necessary, the presented TCS data are also compared to earlier results. Collection of investigated molecular targets (biomolecules, biofuels, molecules of technological application, hydrocarbons) reflects their current interest in biology, medicine, ecology and industry. Most of measurements covered the energy range from about 1 eV to some hundreds of eV, with a few exceptions extending those limits down to near thermal or up to almost high impact energies. The importance of reliable TCS data in the field of electron-scattering physics is emphasized. Problems encountered in TCS experiments are also specified.

Graphical abstract
Model Checking MITL Formulae on Timed Automata
Authors: Menghi Claudio , Bersani Marcello M. , Rossi Matteo , Pietro Pierluigi San 
Published: May 2020

Timed Automata (TA) is de facto a standard modelling formalism to represent systems when the interest is the analysis of their behaviour as time progresses. This modelling formalism is mostly used for checking whether the behaviours of a system satisfy a set of properties of interest. Even if efficient model-checkers for Timed Automata exist, these tools are not easily configurable. First, they are not designed to easily allow adding new Timed Automata constructs, such as new synchronization mechanisms or communication procedures, but they assume a fixed set of Timed Automata constructs. Second, they usually do not support the Metric Interval Temporal Logic (MITL) and rely on a precise semantics for the logic in which the property of interest is specified, which cannot be easily modified and customized. Finally, they do not easily allow using different solvers that may speed up verification in different contexts.
This article presents a novel technique to perform model checking of Metric Interval Temporal Logic (MITL) properties on TA. The technique relies on the translation of both the TA and the MITL formula into an intermediate Constraint LTL over clocks (CLTLoc) formula, which is verified through an available decision procedure. The technique is flexible, since the intermediate logic allows the encoding of new semantics as well as new TA constructs, by just adding new CLTLoc formulae. Furthermore, our technique is not bound to a specific solver as the intermediate CLTLoc formula can be verified using different procedures.
Some Parameterized Dynamic Priority Policies for Two-Class M/G/1 Queues
Authors: Gupta Manu K. , Hemachandra N. , Venkateswaran J. 
Published: May 2020

Completeness of a dynamic priority scheduling scheme is of fundamental importance for the optimal control of queues in areas as diverse as computer communications, communication networks, supply/value chains, and manufacturing systems. Ourfirst main contributionis to identify the mean waiting time completeness as a unifying aspect for four different dynamic priority scheduling schemes by proving their completeness and equivalence in two-class M/G/1 queues. These dynamic priority schemes are earliest due date based, head of line priority jump, relative priority, and probabilistic priority. We discuss major challenges in extending our results to three or more classes.In oursecond main contribution, we characterize the optimal scheduling policies for the case studies in different domains by exploiting the completeness of the above dynamic priority schemes. The major theme of the second main contribution is resource allocation/optimal control in revenue management problems for contemporary systems such as cloud computing, high performance computing, ans so forth, where congestion is inherent. Using completeness and the theoretically tractable nature of relative priority policy, we study the impact of approximation in a fairly generic data network utility framework. Next, we simplify a complex joint pricing and scheduling problem for a wider class of scheduling policies.