bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Antimicrobial, Antioxidant and Molecular Docking Studies on Novel 6-Methoxybenzothiazole-piperazine Derivatives with Propanamide Chain
Authors: Alhusadi Nesrin Atiah , Turgutalp Bengisu , Deniz Inci , Acar Ebru Turkoz , Sipahi Hande , Yarim Mine , Gurdal Enise Ece 
Published: June 2020

Background:
Infectious diseases are a major threat in the developing world and the discovery
of novel antimicrobial agents remains to be crucial due to acquired resistance by the microorganisms.
Additionally, various diseases can be prevented with antioxidant agents as they can eliminate the harmful
effects of reactive oxygen species.

Objective:
In this study, it was aimed to synthesize novel compounds bearing N-(6-
methoxybenzothiazol-2-yl)-3-(4-substitued piperazinyl)propanamide backbone that had antimicrobial
and antioxidant activities. Mechanisms of activity were aimed to be revealed by docking studies.

Methods:
Antimicrobial activities were tested by agar-based disc diffusion assay, and antioxidant activities
were determined by CUPRAC assay.

Results:
In agar-based disc diffusion assay, the most active compounds were 2b and 2e against Staphylococcus
aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. Compounds 2e and
2j showed promising antioxidant activity in CUPRAC assay. Docking studies were performed to optimize
the interactions of compounds with DNA gyrase subunit B of S. aureus. Under the light of docking
studies, a new compound with potential GyrB inhibition was designed. Antioxidant activity was also
supported by docking studies on superoxide dismutase 1 enzyme in which interactions with key residues
were observed.

Conclusion:
Ten novel benzothiazole-piperazine derivatives were synthesized and their antimicrobial
and antioxidant activities were evaluated. Superoxide dismutase 1 enzyme was suggested to be a possible
target for the antioxidant activity of the series.
In Silico ADMET and Docking Studies of Thiazolidinedione-acetic-acid Hybrids as Antidiabetics with Cardioprotection
Authors: Maji Deepanwita , Samanta Subir , Patil Vaishali M. 
Published: June 2020

Background:
Type-2-diabetes mellitus is associated with many side effects affecting vital
body organs, especially heart. Thiazolidinediones are potent antidiabetics. Studies have proven
that amino-acids and peptides promote glucose transport, have antioxidant properties, and fewer side effects,
thus we designed hybrids by combining amino-acid esters and peptide esters with 2, 4
thiazolidinedione acetic acid moiety which can act as antidiabetic agent with cardioprotection properties.

Methodology:
In vitro ADME, toxicity, and docking studies were performed using
Qikprop3.1.OSIRIS, PROTOX (Prediction of Rodent Oral Toxicity), and FlexX 2.1.3, respectively.

Results:
All the designed molecules belong to three sub-series, i.e. 2, 4-dioxothiazolidine-5-acetic
acid single amino acid hybrid methyl esters, 2, 4-dioxothiazolidine-5-acetic acid dipeptide hybrid
methyl esters and 2, 4-dioxothiazolidine-5-acetic acid tripeptide hybrid methyl esters. All molecules
were non-toxic. SSMA2, SSMA14, SSMA49, and SSDM50 showed good docking scores in 2PRG
and 2UV4, respectively.

Conclusion:
The selected in silico studies helped to design hybrids with less toxicity, target specificity
with dual activity as potential anti-diabetic and cardioprotective agents.
An Intelligent Artificial Bee Colony and Adaptive Bacterial Foraging Optimization Scheme for Reliable Breast Cancer Diagnosis
Authors: Punitha S. , Amuthan A. , Joseph K. Suresh 
Published: June 2020

:
Breast cancer is essential to be detected in primitive localized stage for enhancing the
possibility of survival since it is considered as the major malediction to the women society around
the globe. Most of the intelligent approaches devised for breast cancer necessitate expertise that results
in reliable identification of patterns that conclude the presence of oncology cells and determine
the possible treatment to breast cancer patients in order to enhance their survival feasibility. Moreover,
the majority of the existing schemes of the literature incur intensive labor and time, inducing a
predominant impact over the diagnosis time utilized for detecting breast cancer cells. An Intelligent
Artificial Bee Colony and Adaptive Bacterial Foraging Optimization (IABC-ABFO) scheme is proposed
for facilitating a better rate of local and global searching ability in selecting the optimal features
subsets and optimal parameters of ANN considered for breast cancer diagnosis. In the proposed
IABC-ABFO approach, the traditional ABC algorithm used for cancer detection is improved
by integrating an adaptive bacterial foraging process in the onlooker bee and the employee bee
phase that results in optimal exploitation and exploration. The investigation of results of the proposed
IABC-ABFO approach facilitating the use of the Wisconsin breast cancer dataset showed a
mean classification accuracy of 99.52% which is higher than the existing breast cancer detection
schemes.
Optimizing Smartphone-Delivered Cognitive Behavioral Therapy for Body Dysmorphic Disorder Using Passive Smartphone Data: Initial Insights From an Open Pilot Trial
Authors: Weingarden Hilary , Matic Aleksandar , Calleja Roger Garriga , Greenberg Jennifer L , Harrison Oliver , Wilhelm Sabine 
Published: June 2020

Background
Smartphone-delivered cognitive behavioral therapy (CBT) is becoming more common, but research on the topic remains in its infancy. Little is known about how people typically engage with smartphone CBT or which engagement and mobility patterns may optimize treatment. Passive smartphone data offer a unique opportunity to gain insight into these knowledge gaps.

Objective
This study aimed to examine passive smartphone data across a pilot course of smartphone CBT for body dysmorphic disorder (BDD), a psychiatric illness characterized by a preoccupation with a perceived defect in physical appearance, to inform hypothesis generation and the design of subsequent, larger trials.

Methods
A total of 10 adults with primary diagnoses of BDD were recruited nationally and completed telehealth clinician assessments with a reliable evaluator. In a 12-week open pilot trial of smartphone CBT, we initially characterized natural patterns of engagement with the treatment and tested how engagement and mobility patterns across treatment corresponded with treatment response.

Results
Most participants interacted briefly and frequently with smartphone-delivered treatment. More frequent app usage (r=–0.57), as opposed to greater usage duration (r=–0.084), correlated strongly with response. GPS-detected time at home, a potential digital marker of avoidance, decreased across treatment and correlated moderately with BDD severity (r=0.49).

Conclusions
The sample was small in this pilot study; thus, results should be used to inform the hypotheses and design of subsequent trials. The results provide initial evidence that frequent (even if brief) practice of CBT skills may optimize response to smartphone CBT and that mobility patterns may serve as useful passive markers of symptom severity. This is one of the first studies to examine the value that passively collected sensor data may contribute to understanding and optimizing users’ response to smartphone CBT. With further validation, the results can inform how to enhance smartphone CBT design.
Reducing the Text Document Volume Based on Analysis of Its Correlation Dependencies
Authors: Mochenov S. V. , Ahmetgaleev R. R. , Lazarev S. A. 
Published: June 2020

В статье рассматриваются вопросы анализа текстовой информации с целью сокращения ее объема и представления содержания текста произвольных размеров в виде реферата. Текст рассматривается как генеральная совокупность предложений. В качестве основы для проведения анализа текста используются частотные (весовые) характеристики слов, в частности, существительных, используемых автором при построении предложений. Определена роль отдельных категорий слов. На основе весовых характеристик все слова разделяются на многократно и однократно используемые. Сформулированы рекомендации по применению слов-фильтров для извлечения из текста определенных предложений или группы предложений и представления их пользователю. Разработана методика анализа текстового документа. Анализируемый текст разбивается на группы предложений. Многократные слова используются в качестве базовых слов при определении корреляционных зависимостей между предложениями текста. На основе корреляционных зависимостей по каждой группе определяется одно приоритетное предложение, отражающее смысловую составляющую участка текста, задаваемого группой. За счет разбиения на группы достигается сокращение объема текста. Общее число приоритетных предложений соответствует числу групп. Эти предложения могут быть использованы для формирования реферата и предоставляют исследователю (пользователю) адекватную и сжатую информацию о содержании анализируемого документа. В статье приводятся примеры анализа, определяются направления дальнейших исследований.
Extraction, Phytochemical Screening and Anti-Inflammatory Activity of Hydro-Ethanolic Extract of Roots of Dactylorhiza hatagirea
Authors: Sharma Shailja , Jain Prabhat Kumar , Parkhe Geeta 
Published: June 2020

The present work showed phytochemical screening, anti-inflammatory activities and sub-acute toxicity of hydro-ethanolic extract of roots of Dactylorhiza hatagirea (D. hatagirea) and rhizomes of Curcuma angustifolia (C. angustifolia). The anti-inflammatory activity was evaluated by Carrageenan-Induced Rat Paw Edema method. Acute toxicity of the extract (2000 mg/kg) was examined in Swiss albino mice for 14 days. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. Quantitative analysis of phenolic and flavonoids was carried out by Folins Ciocalteau reagent method and aluminium chloride method respectively. Phytochemical analysis revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids. The total phenolics content of roots of Dactylorhiza hatagirea and rhizomes of Curcuma angustifolia extract was (0.675, 0.456mg/100mg), followed by flavonoids (0.832, 1.091mg/100mg) respectively. Hydro-ethanolic extract up to 2000 mg/kg did not produce any toxic effects. The hydro-ethanolic extract of Dactylorhiza hatagirea and Curcuma angustifolia (100 and 200 mg/kg) inhibited the inflammation induced by carrageenan in rats in a dose dependent manner. After anti-inflammatory activity tablet formulation was prepared of the extract and evaluated as per IP. The hydro-ethanolic extract of Dactylorhiza hatagirea and Curcuma angustifolia possesses a strong anti-inflammatory activity and may be considered an interesting source of effective anti-inflammatory compounds.
Keywords: Sub-acute toxicity, anti-inflammatory effect, Dactylorhiza hatagirea, Curcuma angustifolia, Herbal tablet formulation
Majoon-E-Piyaz: A Potent Unani Formulation for Premature Ejaculation
Authors: ALAM SHAH , Anjum Nighat , Akhtar Jamal , Bashir Fouzia , Khan Asim Ali 
Published: June 2020

Surʻat-e-Inzāl (Premature Ejaculation) is the most prevalent male sexual dysfunction affecting 25 - 40% global population of men. It is a universal disorder and is independent of age, social or marital status. It has a significant impact on both- patients and their partners, causing distress, anxiety and relationship difficulties affecting the quality of life. Several aetiologies have been proposed by various researchers which are not evidence-based but speculative. Accordingly the International Society for Sexual Medicine (ISSM) issued treatment guidelines for Premature Ejaculation (PE) recommending Serotonergic Antidepressants (SSRIs) and Local Anaesthetics (LA) for its management in modern medicine. However, these treatments were not actually developed for PE, and have limitations associated with their off-label use. Furthermore, nearly all the recommended drugs have a wider spectrum of adverse effects and serious drug interactions which sometimes could be fatal. On the other hand, centuries old Unani medicine offers a complete line of treatment for Surʻat-e-Inzāl based on traditional knowledge and experience. Unani physicians devised a large number of poly-herbal recipes which are still in vogue. Majoon-e-Piyaz (MP) is one of the compound Unani formulations which are in use for the treatment of premature ejaculation since centuries. This article is an attempt to summarize scientific investigations in support of the claim made by Unani physicians regarding Majoon-e-Piyaz (MP).
Keywords: Surʻat-e-Inzāl, Premature Ejaculation, Majoon-e-Piyaz, Unani Medicine
Total Phenolic Contents and Antioxidant Properties of Algerian Arbutus unedo L. Extracts
Authors: Laouicha Saliha , Senator Abderrahmane , Kherbache Abdallah , Bouriche Hamama 
Published: June 2020

Arbutus unedo L. is a plant widely distributed in the Mediterranean basin and North Africa, frequently used in traditional folk medicine to treat diabetes and arterial hypertension. This study aims to evaluate the phenolic composition and antioxidant activity of ethyl acetate (EA.E) and n-butanolic (But.E) extracts prepared from leaves of Arbutus unedo. Total phenolic and flavonoids contents were determined spectrophotometrically. The antioxidant activity was evaluated using DPPH•, OH•, H2O2, O•-2, ß-carotene bleaching and AAPH-induced erythrocyte oxidative hemolysis assays. The phytochemical analysis showed the presence of polyphenols and flavonoids in both extracts. The high amount was observed in EA.E which exerted the stronger antioxidant effect, with IC50 values of 3.43 μg/mL, 323.45 µg/mL, 38.40 µg/mL and 11.56 µg/mL, in DPPH•, OH•, O•-2 and H2O2 tests, respectively. Both extracts inhibited β-carotene bleaching, but EA.E is always more potent (92%) than But.E (85%). Furthermore, the EA.E showed the highest protective effect on erythrocyte hemolysis induced by AAPH, with half time hemolysis (HT50) of 122.02 min at 40 µg/mL. Taken together, this study showed that Arbutus unedo leaf extracts possess strong antioxidant potential, which may be attributed to the presence of a high amount of polyphenolic constituents. So, this plant might be exploited as a potential source of natural antioxidant agents for pharmaceutical and food applications.
Keywords: oxidative stress, antioxidant, phenolic compounds, Arbutus unedo.
Kielioppi kerrosten ja kytkentöjen verkostona
Authors: Hamunen Markus 
Published: June 2020

Arvioitu teos:
Urpo Nikanne: Conceptual semantics. A micro-modular approach. Constructional Approaches to Language 23. Amsterdam: John Benjamins Publishing Company 2018. xvi + 281 s. isbn 978-90-272-0117-1.
DEVELOPMENT OF AN INTERACTIVE ONLINE ETHICS SCENARIO ACTIVITY FOR ENGINEERING STUDENTS
Authors: Ostafichuk Peter M. , P. Jaeger Carol , Nakane Jonathan 
Published: June 2020

This paper describes development and deployment of an online interactive ethical decision-making simulation. This tool was piloted in a first-year introduction to engineering course at the University of British Columbia. It used a “choose your own adventure” style of decision-making and narrative to add realism and engagement to what was otherwise viewed by students as dry, uninteresting content. After storyboarding using sticky notes and Visio, the final tool used by students was implemented and deployed using a survey tool (Qualtrics). It featured a scenario with initially incomplete information and the appearance of unethical behaviour by others. It included decision-based branching, but also randomization such that different groups had the story unfold differently, even if they made the same initial decisions. Student feedback on this tool was very positive, suggesting this style of interactive online ethics simulation could be an effective tool for enhancing engagement and learning.
LEGO SERIOUS PLAY AND THE GRADUATE ATTRIBUTES
Authors: Balakrishnan R. , Seniuk Cicek J. , Mani P. , Mann D. 
Published: June 2020

As part of a longitudinal project to integrate career development supports into a biosystems engineering classroom, students engaged in a LEGO© Serious Play workshop and wrote reflections on their experiences. This workshop provided opportunities for teambuilding and deliberations on what constitutes a strong team. A constructivist grounded theory analysis of students’ reflections was conducted. Through this analysis, a preliminary theme of Perceptions of Engineering Skill emerged, with three subthemes of the necessity of teamwork and communication to engineering; the vulnerability in making interpersonal connection; and the explicit connection of engineering to creativity. These skills can be conceptualized within the CEAB graduate attributes and theorized within the systems theory framework (STF) of career development, which positions the students’ skill development within the larger context of their career. Ultimately, the preliminary findings of this study provide a starting point for further analysis, and for the development of an interview protocol for the longitudinal study this project sits within, with the overarching goal to investigate the impact of career supports and process of career development in a professional degree program.
Efektivitas Intervensi Kelompok untuk Meningkatkan Self-Esteem pada Mahasiswa dengan Test Anxiety
Authors: Melisa Melisa , Pohan Lifina Dewi 
Published: June 2020

Test is defined as an indicator of success for college students in education. As a result, college students often feel anxious when faced with test and this is called test anxiety. Test anxiety will negatively affect performance’s college students and inhibit student to complete their academic demands. Self-esteem becomes the main factor of college students experiencing test anxiety. The purpose of this study is explain the effectiveness of group intervention in improving self-esteem of college students who experience test anxiety. Intervention is conducted over 4 sessions (90 - 135 minutes each session) by including some strategies such as cognitive restructuring, study skills & habits, self-care, timing, mindfulness, breathing and relaxation techniques, self-control desensitization , and exercises manage distractions. This research method used one group before after design. The number of participants who followed the study were 5 college students. Based on the comparison of pre-test and post-test, the results were as following: (a) the anxiety test score of five participants decreased after therapy; (b) the self-esteem score of three participants increased after therapy. The five participants also showed more adaptable beliefs, decreased physiological reactions, and improved behavior that may degrade performance when dealing with test situations. In addition, all participants began to learn to see the positive qualities within themselves to improve their self-esteem. The results show that group intervention is effective in reducing test anxiety and increasing self-esteemKeywords: Group intervention, self-esteem, test anxiety
On the golden number and Fibonacci type sequences
Authors: Barcz Eugeniusz 
Published: June 2020

The paper presents, among others, the golden number $\varphi$ as the limit of the quotient of neighboring terms of the Fibonacci and Fibonacci type sequence by means of a fixed point of a mapping of a certain interval with the help of Edelstein's theorem. To demonstrate the equality , where $f_n$ is $n$-th Fibonacci number also the formula from Corollary \ref{cor1} has been applied. It was obtained using some relationships between Fibonacci and Lucas numbers, which were previously justified.
Azərbaycan şəraitində qulaqlı kirpilərin (Hemiechinus auritus G. 1770) makromorfoloji əlamətləri
Authors: Alizada S.A.  
Published: June 2020

Tədqiqatın məqsədi Azərbaycanda rast gəlinən kirpi növlərini morfologiyasını, bioekoloji xüsusiyyətlərini, respublikamızın teriofaunasındakı taksonomik statusunu müəyyənləşdirməkdir.
Tədqiqatın material və metodları: Material olaraq, Azərbaycan respublikasının müxtəlif regionlarından toplanan kirpilərdən istifadə olunmuşdur. Tədqiqat nəticəsində alınan məlumatlar N.A. Ploxinskiy və E.V. İvanter, A.V. Korosovaya görə hesablanaraq bioloji və riyazi xətaları azaldılmışdır. Stasionar tədqiqat ərazilərində kirpilərin rast gəlmə tezliyi Rafkinə ğörə verilən düsturla hesablanıb. Növü təyin edərkən Pavlinov və b-nın irəli sürdükləri morfofizioloji indikator metodundan istifadə edilmişdir.
Tədqiqatın nəticələri: Qulaqlı kirpi maksimum çəki artımına qış yuxusuna getməzdən öncə çatırlar, bu məsələdə də cinsi dimorfizm özünü göstərir. Qulaqlı kirpinin kəlləsinin kranioloji ölçüləri bölgələrdən asılı olaraq, xarakter formada dəyişir və minimum ölçü ilə maksimum ölçü arasında kifayət qədər fərq müşayiət olunur. Postnatal inkişafın erkən dövründə tikanların sürətlə inkişafı və tez bir zamanda codlaşması kirpilərin tarixi inkişafında yaşamaq uğrunda qazandığı uyğunlaşma əlamətidir. Qulaqlı kirpilərin daxili orqalarının indeksi göstərir ki, ürək və qaraciyərin nisbi kütləsi ilin fəsillərindən, heyvanın fizioloji vəziyyətindən, cinsindən və yaşından asılı olaraq dəyişir.
Yekun: Tədqiq olunan qulaqlı kirpilərin kranioloji göstəricilərində kəllənin kondilobazal uzunluğu, burun sümüyünün uzunluğu və alın sümüyü ölçülərində növdaxili populyasiya fərqinin olması müşahidə olunur. Belə ki, həm qulaqlı kirpilərin şimal populyasiyası nümayəndələrinin kəllə ölçüləri cənub populyasiya fərdlərindən aşağıdır. Qulaqlı kirpilərin daxili orqalarının indeksinin dəyişilmələri respublikamızın öyrənilən bölgələrinin hər birində özünəməxsus şəkildə müşahidə olunur. Bu zaman müşahidə olunan bölgələrarası fərq yüksək deyil.
Studi Karakteristik Sifat Kualitatif Dan Morfometrik Induk Ayam Kampung Dengan Berbagai Tipe Jengger Di Pulau Lombok
Authors: Lestari Lestari , Maskur Maskur , Jan Rahma , Rozi Tapaul , Kasip Lalu M. , Muhsinin M. 
Published: June 2020

This study aimed to identify the diversity of qualitative and morphometric traits of Kampung chickens based on the comb-types in Lombok Island. Four hundred and seventeen Kampung chickens that are maintained traditionally were used in this study. The method used was a survey. The determination of location was done by purposive sampling, and samples taken were selected by random sampling. Qualitative data included comb-type, fur color, skin color, and foot color. Morphometric data included comb height, shank length, tibia length, femur length, the distance between pubic bones, the distance between the pubic bone and breastbone and body weight. Data were analyzed using simple statistical analysis. The results show that there were 4 (four) types of comb namely walnut comb (36.45 percent), single (30.45 percent), pea (24.46 percent) and rose (8.64 percent). Fur colors found were black, golden, striated and white. White fur color was only found in pea combs. The earlobe colors were red and white. Shank colors were black, white and yellow. The skin colors were yellow and white. The highest morphometrics of Kampung chicken was found in chickens with the type of rose comb which showed comb height of 12.16 + 2.78mm, shank length of 74.26 + 11.62mm, tibia length of 88.47 + 11.87mm, femur length of 82.11 + 12.45mm, distance of two pubic bones of 35.95 + 7.32mm), distance between the pubic bone and breastbone of 54.74 + 9.86mm and body weight of 1658.19 + 339.63gram.