bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cemented versus uncemented total hip replacement for femoral neck fractures in elderly patients: a retrospective, multicentre study with a mean 5-year follow-up
Authors: Mao Shuai , Chen Baomin , Zhu Ying , Qian Liang , Lin Jinluan , Zhang Xinchao , Yu Weiguang , Han Guowei 
Published: September 2020

Abstract
Background
Cemented or uncemented total hip replacement (CTR or UTR) for femoral neck fractures (AO/OTA type 31B/C) is a relatively common procedure in elderly individuals. The recent literature is limited regarding long-term outcomes following CTR versus UTR in the Asian population.

Methods
Using our institutional database, we performed long-term outcome analysis on 268 patients with femoral neck fractures (AO/OTA type 31B/C) who had undergone a primary UTR or CTR (CTR: n = 132, mean age, 67.43 ± 6.51 years; UTR: n = 136, mean age, 67.65 ± 6.13 years) during 2007–2014, and these patients were followed until 2019. Follow-up occurred 1, 3, 6, and 12 months postoperatively and yearly thereafter. The primary endpoint was the Harris hip score (HHS); the secondary endpoint was the incidence of orthopaedic complications.

Results
The mean follow-up time was 62.5 months (range, 50.1–76.1 months). At the final follow-up, the HHS was 79.39 ± 16.92 vs 74.18 ± 17.55 (CTR vs UTR, respectively, p = 0.011). Between-group significant differences were observed regarding the incidence of prosthesis revision, prosthesis loosening, and periprosthetic fracture (7.6% [95% CI, 6.4–8.2] for CTR vs 16.9% [95% CI, 14.7–17.3] for UTR, p = 0.020; 9.8% [95% CI, 8.3–10.7] for CTR vs 19.9% [95% CI, 18.2–20.9] for UTR, p = 0.022; 5.3% [95% CI, 4.4–6.7] for CTR vs 13.2% [95% CI, 12.1–13.8] for UTR, p = 0.026, respectively).

Conclusion
CTR showed superiority to UTR by improving the HHS and decreasing the incidence of orthopaedic complications. Our findings need to be confirmed in a prospective, randomized controlled study to verify whether they can be applicable to a broader population.
Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway
Authors: Liang Feng , Fu Xin , Li Yunpengfei , Han Fanglei 
Published: September 2020

AbstractThis study investigated the protective effect of desoxyrhapontigenin (DOP) against isoflurane (ISF)-induced neuronal injury in rats. Neuronal injury was induced in pups by exposing them to 0.75% ISF on postnatal day 7 with 30% oxygen for 6 h. The pups were treated with DOP 10 mg/kg, i.p., for 21 days after ISF exposure. The protective effect of DOP was estimated by assessing cognitive function using the neurological score and the Morris water maze. Neuronal apoptosis was assessed in the hippocampus using the TUNEL assay, and protein expression of caspase-3, Bax, and Bcl-2 was measured by Western blotting. The levels of cytokines and oxidative stress parameters were assessed by ELISA. Western blotting and RT-PCR were performed to measure the expression of NF-kB, TLR-4, Sirt-1, and cyclin B1 protein in the brain. The cognitive function and neurological function scores were improved in the DOP group compared with the ISF group. Moreover, DOP treatment reduced the number of TUNEL-positive cells and the expression of caspase-3, Bax, and Bcl-2 protein in the brains of rats with neuronal injury. The levels of mediators of inflammation and oxidative stress were reduced in the brain tissue of the DOP group. Treatment with DOP attenuated the protein expression of TLR-4, NF-kB, cyclin B1, and Sirt-1 in the brain tissue of rats with neuronal injury. In conclusion, DOP ameliorates neuronal apoptosis and improves cognitive function in rats with ISF-induced neuronal injury. Moreover, DOP treatment can prevent neuronal injury by regulating the TLR-4/cyclin B1/Sirt-1 pathway.
Textiles and environment in the showcase containing Saint Canute the Holy († AD 1086): Radiocarbon dating and chemical interactions
Authors: Grinder-Hansen Poul , Kjær Ulla , Ryhl-Svendsen Morten , Colombini Maria Perla , Degano Ilaria , La Nasa Jacopo , Sabatini Francesca , van der Plicht Johannes , Rasmussen Kaare Lund 
Published: September 2020

Abstract
The cathedral in Odense, Denmark, has for nine centuries held the relics of the Danish King St Canute the Holy and his brother Benedikt. They were both murdered in the predecessor church at the site in AD 1086, and Canute was sanctified in already in AD 1100. The history of the relics has been that of turmoil at times, varying from initial worship of the Catholic believers, to being walled up and hidden away after the protestant reformation in AD 1536, and since the 19th Century on display as important heritage objects of national importance. In the present work we have characterised some of the textiles and analysed the air inside the glass showcases exhibiting the 11th Century wooden coffins holding the remains of St King Canute the Holy and his brother together with some precious textiles. Contrary to previous belief, we now prove that all the textiles analysed have the same age, which is consistent with the time of the enshrinement of the King and his brother in AD 1100. It is also shown that some of the textiles were treated with paraffin wax, most likely during attempts at conservation at the National Museum in the nineteenth century. The results of the air chemistry analyses show the problematic side of simultaneously storing of slowly decaying wood, fine textiles, and human bones in rather airtight environments. The wood continuously releases organic acids, the soaring concentrations of which are potentially harmful to the 11th Century textiles and probably also to the bones.
Inhibition of phospholipase D2 augments histone deacetylase inhibitor-induced cell death in breast cancer cells
Authors: Hwang Won Chan , Kang Dong Woo , Kang Youra , Jang Younghoon , Kim Jung-Ae , Min Do Sik 
Published: September 2020

Abstract
Background
Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their effect on tumor treatment has been disappointing mainly due to the acquisition of HDAC inhibitor resistance. However, the mechanisms underlying such resistance remain unclear.

Methods
In this study, we performed Western blot, q-PCR, and promoter assay to examine the expression of HDAC inhibitor-induced phospholipase D2 (PLD2) in MDA-MB231and MDA-MB435 breast cancer cells. Apoptosis and proliferation were analyzed by flow cytometry. In addition to invasion and migration assay, angiogenesis was further measured using in vitro tube formation and chick embryo chorioallantoic membrane model.

Results
HDAC inhibitors including suberoylanilide hydroxamic acid (SAHA), trichostatin, and apicidin, induce expression of PLD2 in a transcriptional level. SAHA upregulates expression of PLD2 via protein kinase C-ζ in breast cancer cells and increases the enzymatic activity of PLD. The combination treatment of SAHA with PLD2 inhibitor significantly enhances cell death in breast cancer cells. Phosphatidic acid, a product of PLD activity, prevented apoptosis promoted by cotreatment with SAHA and PLD2 inhibitor, suggesting that SAHA-induced PLD2 expression and subsequent activation of PLD2 might confers resistance of breast cancer cells to HDAC inhibitor. The combinational treatment of the drugs significantly suppressed invasion, migration, and angiogenesis, compared with that of either treatment.

Conclusion
These findings provide further insight into elucidating the advantages of combination therapy with HDAC and PLD2 inhibitors over single-agent strategies for the treatment of cancer.
Impact of metal implants on xSPECT/CT Bone reconstruction: the “shining metal artefact”
Authors: Lima Thiago V. M. , Bhure Ujwal , Pérez Lago Maria de Sol , Thali Yannick , Matijasevic Savo , Roos Justus , Strobel Klaus 
Published: September 2020

Abstract
Background
Novel reconstruction algorithms, such as xSPECT Bone, are gaining more and more importance in Nuclear Medicine. With xSPECT Bone, the reconstructed emission image is enhanced by the information obtained in the corresponding CT image. The CT defines tissue classes according to the Hounsfield units. In the iterative reconstruction, each tissue class is handled separately in the forward projection step, and all together in the back projection step. As a consequence, xSPECT Bone reconstruction generates images with improved boundary delineation and better anatomic representation of tracer activity. Applying this technique, however, showed that artefacts may occur, when no uptake regions, like metal implants, exhibit fictitious uniform tracer uptake. Due to limitations in spatial resolution in gamma cameras, the xSPECT Bone reconstructed image resulted in spill-out activity from surrounding high uptake region being uniformly distributed over the metal implants.
This new technology of xSPECT Bone reconstruction in general enhances the image quality of SPECT/CT; however, the potential introduction of specific artefacts which inadvertently come along with this new technology and their frequency have not yet been addressed in the literature. Therefore, the purpose of this work was to identify and characterize these specific metal artefacts (the so-called shining metal artefact) in order to reduce false positives and avoid potentially misdiagnosing loosened or infected implants.

Case presentation
In this work, we report five cases imaged with bone SPECT/CT of 5 anatomical regions (foot, elbow, spine, shoulder, ribs and knee). All cases demonstrated “shining metal artefacts” in xSPECT Bone reconstruction.

Conclusion
While xSPECT Bone reconstruction algorithm significantly improves image quality for the diagnosis of bone and joint disorders with SPECT/CT, specific “shining metal artefacts” caused by the xSPECT Bone have to be recognized in order to avoid image misinterpretation suggesting metallic implant loosening or possible infection. The simultaneous analysis of conventionally reconstructed SPECT images (for Siemens the Flash3D reconstruction) helps to avoid misinterpretation of potential artefacts introduced by xSPECT Bone reconstruction.
A comparative study on early vision quality after implantation of refractive segmental and diffractive multifocal intraocular lens
Authors: Lian Huifang , Ma Weisong , Wei Qiuhong , Yuan Xiaoyong 
Published: September 2020

Objectives: To compare early subjective and objective vision quality of postoperative patients undergoing phacoemulsification cataract surgery combined with implantation of refractive segmental multifocal intraocular lens (MIOL) SBL-3 and apodized diffractive MIOL SN6AD1.
Methods: As a prospective study, it enrolled 53 patients (53 eyes) to undergo phacoemulsification cataract surgery combined with MIOL implantation. According to differences in MIOL implanted, patients were divided into a SBL-3 group (25 eyes) and a SN6AD1 group (28 eyes). Ophthalmological evaluation included uncorrected (UDVA) and corrected (CDVA) distance visual acuities, uncorrected intermediate (UIVA) and near (UNVA) visual acuities, distance-corrected intermediate (DCIVA) and near (DCNVA)visual acuities and corrected near(CNVA) visual acuity, contrast sensitivity, modulation transfer function (MTF) and high order aberration (4 mm pupil diameter) at three months postoperatively. Moreover, a questionnaire survey was carried out to assess near spectacle independence, patient satisfaction and symptoms of visual disturbance.
Results: At three months after surgery, UIVA and UNVA in the SBL-3 group are statistically significantly superior to those of the SN6AD1 group (P<0.05). There was statistical difference in contrast sensitivity at four spatial frequencies (3, 6, 12, 18cycles/degree) under mesopic conditions and mesopic conditions with glare (P<0.05). The total ocular high order aberration, coma and trefoil were statistically significantly larger in the SBL-3 group than in the SN6AD1 group with 4.0 mm pupil diameters (P<0.05). Statistical differences were found in the MTF at spatial frequencies of 5, 10 and 15 cycles/degree between the groups. There were no significant differences in spectacle independence, patient satisfaction and visual disturbance between the groups (P>0.05).
Conclusions: Both the two multifocal intraocular lens provided an excellent level of quality of vision three months postoperatively. However, the application effect of SBL-3 MIOL is superior to that of SN6AD1 MIOL as far as intermediate vision, near vision and contrast sensitivity are concerned.
doi: https://doi.org/10.12669/pjms.36.7.3364
How to cite this:Lian H, Ma W, Wei Q, Yuan X. A comparative study on early vision quality after implantation of refractive segmental and diffractive multifocal intraocular lens. Pak J Med Sci. 2020;36(7):1607-1612. doi: https://doi.org/10.12669/pjms.36.7.3364
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HIV index testing services in urban Lusaka: a review of medical records
Authors: Katamba Cibangu 
Published: September 2020

Background: As the proportions of people living with HIV (PLHIV) who do not know their HIV infection status decrease, reaching the remaining few who are asymptomatic and not in contact with the health care system becomes a critical challenge. Therefore, reaching the first 90 of the UNAIDS 90-90-90 targets will require effective and efficient HIV testing approaches. The number of PLHIV who know their HIV status and who receive antiretroviral therapy could increase by the expansion of index testing services. Methods: This project was a retrospective study looking at medical records of HIV positive clients who were elicited for index testing between October and December 2019. It was conducted in three high volume health facilities in Matero Urban sub-district 3 in Lusaka, Zambia. Results: The HIV test outcomes for index contacts were as follows: 452 index contacts (53.5%) tested HIV negative, 113 index contacts (13.4%) tested HIV positive, 108 index contacts (12.8%) were known HIV positive, and 172 index contacts (20.4%) were not yet tested for HIV. Of the 113 contacts who tested HIV positive, 90 index contacts started anti-retroviral therapy within 7 days (79.6%). The total number of 845 contacts were elicited from 604 index clients, giving a low elicitation ratio of 1:1.4. There was not much difference between gender for elicited contacts (423 men and 422 women). A total number of 565 index contacts were eligible for HIV test. 113 of them tested HIV positive, representing a positivity yield of 20%. Pearson Chi-Square test value was 0.498 and the p value was 0.481. This result is not significant since p value (0.481) is greater than the designated alpha level (0.05). Conclusions: HIV programs need to explore and address barriers to HIV partner testing services to maximize HIV case identification.
A Cross-Sectional Machine Learning Approach for Hedge Fund Return Prediction and Selection
Authors: Wu Wenbo , Chen Jiaqi , Yang Zhibin (Ben) , Tindall Michael L. 
Published: September 2020

We apply four machine learning methods to cross-sectional return prediction for hedge fund selection. We equip the forecast model with a set of idiosyncratic features, which are derived from historical returns of a hedge fund and capture a variety of fund-specific information. Evaluating the out-of-sample performance, we find that our forecast method significantly outperforms the four styled Hedge Fund Research indices in almost all situations. Among the four machine learning methods, we find that deep neural network appears to be overall most effective. Investigating the source of methodological advantage of our method using a case study, we find that cross-sectional forecast outperforms forecast based on time series regression in most cases. Advanced modeling capabilities of machine learning further enhance these advantages. We find that the return-based features lead to higher returns than the benchmark of a set of macroderivative features, and our forecast method yields best performance when the two sets of features are combined. This paper was accepted by David Simchi‐Levi, finance.
The surgical and non-surgical challenges of COVID-19
Authors: Winter G 
Published: September 2020

Within days of the emergence of the COVID-19 pandemic, the COVIDSurg Collaborative was established, to which 88 countries signed up to support pandemic-related surgical planning and practice. COVID-19-related surgical challenges considered include cancer surgery, colorectal surgery, robot assisted surgery, spinal surgery, surgical education and tracheal injury repair. Non-surgical aspects of COVID-19 include ethical challenges and the emotional challenges of both patients and staff. Future consideration should be given to different organisational approaches and to pandemic planning that anticipates further waves of COVID-19 infection. Patients and staff may need to undergo rigorous screening to minimise the risk of cross-infection. In view of a second wave, George Winter explores how surgeons and physicians adapt and improve during persistent uncertainty.
Logic gates for terahertz frequencies fabricated by three-dimensional printing
Authors: Ortiz-Martinez M. , Hernandez-Serrano A. I. , Justo Guerrero M. A. , Strupiechonski E. , Castro-Camus E. 
Published: September 2020

The so-called terahertz band of the electromagnetic spectrum falls in a spectral region where traditional electronic technologies fail to operate owing to the extremely short switching times required. In this paper, we demonstrate the design of three optical logic gates fabricated by three-dimensional printing, which can perform the OR, AND, and XOR logic operations at 130 GHz. In order to optimize our designs we used a finite element electromagnetic simulation. The amplitude spectra of the experimental measurements of the three devices are presented where good agreement between the numerical results and experimental data can be seen. These results lead to the possibility of building more complex logic circuits based on these three photonic logic gates.
Framing terrorism: A comparative content analysis of ISIS news on RT Arabic and Sky News Arabia websites
Authors: Al Ibrahim Daleen , Shi Yibin 
Published: September 2020

Abstract
This study compares RT Arabic and Sky News Arabia websites in their coverage of the Islamic State of Iraq and Syria violent organization known as ISIS from 1 June 2014 until 30 June 2016, in terms of framing type and the image reflected about ISIS. The quantitative content analysis of the news articles shows similarities and few differences in the news coverage of ISIS. The study suggests that RT and Sky News share a few features in framing ISIS but still differ significantly. The two websites adopt mainly the conflict frame in presenting ISIS issues; however, they report ISIS differently when it comes to violence and human interest frames. The findings also reveal that RT and Sky News differ partially in the image reflected about ISIS on their websites. RT has exaggerated ISIS’s image more distinctly than Sky News. Besides, even though threat is the most dominant discourse about ISIS in the two websites, RT promotes ISIS as powerful and exaggerates its strength in its coverage more than Sky News.
Sustainable Local Development in Romania in the Opportunity of Creating Jobs
Authors: Bran Florina , Ciobanu Ghenadie , Popescu Maria Loredana , Vasilache Petrut Cristian 
Published: September 2020

The economic, social transformations of the last three decades of evolution of rural development both in Romania and in general in rural areas in the context of globalization have radically changed the vision, thinking and attitude of the rural population. As a result, it has led to a massive migration of population to other developed countries. This phenomenon is also characteristic for Romania. At the same time, the technological development has a massive impact on the process of organizing the society and the evolution of the society, both the evolution of biotechnologies, nanotechnologies, branches in the field of chemistry, biochemistry and digitization, which have impact on the development or underdevelopment of the areas in poverty and underdevelopment. economic, but at the same time they will be able to make an essential contribution to the local rural development and to the creation of new job opportunities for both young people and specialists from different branches, as well as for vulnerable groups of population from the rural area. In this article we aim to address these issues and come up with certain solutions and proposals.
Keywords: Sustainable local development, rural areas, technological development, digitization
Saving Water for the Future Via Increasing Plant Literacy of Pupils
Authors: Ryplova Renata , Pokorny Jan , Ryplova Renata 
Published: September 2020

The struggle for mitigation of global climate changes is aimed mostly on CO2 emissions, while the role of vegetation having strong impact on water retention in the landscape and cooling of environment stays out of the focus. The reason is human illiteracy of plant role in our environment having roots already in school education. The vegetation use the majority of solar energy for the water evaporation from leaves and by this way cools itself as well as environment and increase water retention in the landscape. Insufficient understanding of these processes leads to no proper landscape management resulting in further increase of drought and climate further draft interrupted by torrential rains and climate extremes. To stop over drying and ensure sustainable economy and environment for the future it is necessary to increase general public understanding of the principles of solar energy distribution by vegetation and its role in water cycle in the landscape via improving school education. This contribution inform about the new teaching methodology on this topic developed by co –operation of scientists and educators and implemented into the education at Czech basic schools. The results of the survey aimed on the impact of this teaching methodology on students’ knowledge of plant role in environment are included and necessity of implementation of this topic into sustainable education is discussed.
Keywords: Water, vegetation, solar energy, environmental education, climate
Alternative Urban Eco Tours for Responsible Consumption and Sustainability – the Example of Bulgaria
Authors: Bancheva-Preslavska Hristina , Dallmer Jochen 
Published: September 2020

The European Environment Agency warns that Europe consumes too many resources and causes environmental degradation all over the world. This leads to growing demands on natural systems for food, water and energy. To achieve sustainability and ecological resilience it is necessary to complement technology-focused measures with approaches addressing consumption behaviors, changing lifestyles, enhancing knowledge and education.
There are environmental communication approaches stimulating responsible consumption and ecofriendly behaviors, conducted by science and educational institutions, non-governmental organizations and others. Among them, originating from Germany, are the alternative city tours, spread also in other western countries.
The aim of this case study is to design and verify urban eco tours for an eastern country - Bulgaria in order to increase young people's sensitivity to sustainability through responsible consumption and to encourage them for ecofriendly alternatives of everyday goods and services. An approach for their implementation in Bulgaria is developed and proved through qualitative and quantitative analysis, involving two different groups of youth – multipliers leading the tours and teenagers taking part.
The case study presents urban eco tours as an environmental protection tool, using information about environmental impact of consumption, combined with motivational activities, to change attitudes and encourage young people for ecofriendly lifestyles.
Keywords: environmental communication, education for sustainable development, eco tour, consumption, ecology