bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Determinants and Experiences of Senior Stroke Patients with Virtual Care
Authors: Chan Sophy , O’Riordan Anne , Appireddy Ramana 
Published: July 2020

ABSTRACT:Objective:The study sought to explore the experiences of participants affected by stroke with home video visit (HVV) for follow-up visits in order to understand the determinants, barriers, and benefits associated with HVVs.Methods:Semi-structured interviews were conducted with (n= 23) participants to gather insight and descriptive information about patients’ experiences with HVV. Specifically, we sought to collect descriptions about the (1) costs and time associated with in-person visits, (2) facilitators and barriers to in-person and virtual visits, and (3) their values attached to traditional and virtual forms of patient care.Results:HVVs were perceived to be a mode of healthcare that is time-saving and convenient for both participants and physicians. However, our study also found some participants felt uncomfortable using technology to conduct medical visits while others still supported a positive view of traditional forms of in-person visits because they valued the in-person interactions and safe environment of the hospital.Conclusion:While HVVs were considered to be useful in addressing geographical barriers to health care, technological and digital health literacy may serve to impede seniors from using the service, with some of them opting to go to the hospital despite geographical barriers. Resultantly, HVVs may serve both to alleviate and exacerbate certain determinants to health care.
Maximizing Health-Care Capacity in Response to COVID-19 Outbreak: Rapid Expansion Through Education by Health Emergency and Disaster Experts
Authors: Kato Soichiro , Miyakuni Yasuhiko , Inoue Yoshitaka , Yamaguchi Yoshihiro 
Published: July 2020

ABSTRACTDelivering adequate health care in the setting of the ongoing pandemic is challenging. Due to coronavirus disease 2019 (COVID-19), the Tokyo Metropolitan government has been forced to expand their acute health-care capacity corresponding to infectious diseases within a short period. Responding to this situation, health emergency and disaster experts of the Tokyo Disaster Medical Assistance Team took the initiative in creating a brief education course. We established the course for expanding infectious disease care capacity by a dedicated hands-on lecture for health professionals who are unfamiliar with infectious disease care in ordinary circumstances. Our lecture included the typical course of COVID-19, use of personal protective equipment, environmental sterilization, medical-ward zoning, and safe caregiving. Hospitals that received customized lectures reported by means of a questionnaire that the lectures were well suited to their needs. Currently, the health-care system in Tokyo has increased its capacity to meet the demand and has not been affected by COVID-19. Our experience shows that health emergency and disaster experts can assist hospitals in crisis by providing educational materials.
Logos on Everest: Commercial Sponsorship of American Expeditions, 1950–2000
Authors: GROSS RACHEL S. 
Published: July 2020

In the 1950s, outdoor retailer Eddie Bauer donated down jackets to American mountaineers embarking on climbing expeditions in the Himalayas. In the 1990s, chemical manufacturer W. L. Gore & Associates donated both goods and $2 million to an expedition in Antarctica. The funds dedicated to sponsorship by the end of the twentieth century reflect a shift in how companies saw expeditions as useful to their marketing goals. This article uses two archives previously unexplored by historians that offer an unprecedented chance to compare sponsorship relationships in a single industry across decades. Commercial sponsorship of American expeditions and athletes has undergone three dramatic changes since 1950, and these shifts help explain how sponsorship as a form of marketing became so popular. Sponsorship contracts shifted from vague to specific as a result of decades of unsatisfying results for corporate sponsors. Sponsored athletes became business partners and began taking an active role in promoting the companies that provided them cash or donations in-kind. Finally, companies developed strategies for leveraging their sponsorship deals. The changing landscape of the business of expeditions ultimately reveals how the most long-lasting legacies of these extreme adventures happened far from the trail and much closer to company boardrooms, sponsorship managers’ offices and retail stores where consumers learned to engage with the narratives companies and athletes had crafted together.
STRONG FANS, WEAK CAMPAIGNS: SOCIAL MEDIA AND DUTERTE IN THE 2016 PHILIPPINE ELECTION
Authors: Sinpeng Aim , Gueorguiev Dimitar , Arugay Aries A. 
Published: July 2020

AbstractThe 2016 presidential contest is widely considered as the first “social media election” in the Philippines. At the same time, it remains unclear if or how social media helped Rodrigo Duterte mobilize voters to gain victory. There are three main social media campaigning models: broadcast, grassroots, and self-actualizing. Analysis of twenty million activities and 39,942 randomly sampled comments across the official Facebook pages of key presidential candidates supports the grassroots model as Duterte's profile was the most engaged, even if Duterte himself was not actively engaged. Such inconsistencies raise the prospect that Duterte's online prominance was fabricated by paid trolls and fake accounts. Instead, our analysis suggests that Duterte's digital fanbase was, at least in part, a reflection of offline, grassroots political support. In particular, data from an original survey of 621 respondents suggests that Duterte supporters were not only aggressive in their support for Duterte online, they were also more committed to him offline as well. These findings add to a growing literature on social media and politics that seeks to understand the broader ecosystem of online political discourse, rather than focusing on the actions and strategies of political campaigns. They also underscore the fine line between fabricated support and genuine political fervor.
PRETREATMENT PROTOCOLS PERFORMED AT THE ROYAL INSTITUTE FOR CULTURAL HERITAGE (RICH) PRIOR TO AMS 14C MEASUREMENTS
Authors: Wojcieszak Marine , Van den Brande Tess , Ligovich Gaia , Boudin Mathieu 
Published: July 2020

ABSTRACTThe Royal Institute for Cultural Heritage (RICH) radiocarbon (14C) laboratory in Brussels, Belgium, has acquired experience for pretreating samples with 60 years of involvement in 14C dating, and the implementation of routine protocols. These procedures as applied to wood, seeds, charred materials, bones, ivory, textiles (silk, wool, cotton, linen), paper, shells, cremated bones, mortars, lead carbonates, sediments, etc. are described in detail in this paper. They are evaluated against reference materials.
Supercritical carbon dioxide extracts of small cardamom and yellow mustard seeds have fasting hypoglycaemic effects: diabetic rat, predictive iHOMA2 models and molecular docking study
Authors: Paul Kaninika , Chakraborty Soumi , Mallick Priyanka , Bhattacharjee Paramita , Pal Tapan Kumar , Chatterjee Nilendra , Chakrabarti Saikat 
Published: July 2020

AbstractIn the present investigation, the supercritical carbon dioxide (SC-CO2) extracts of small cardamom (SC) and yellow mustard (YM) seeds have been investigated for their efficacies in combating type 2 diabetes in streptozotocin-induced Wistar albino rats. Fasting blood glucose (FBG) levels in the rats were monitored on days 8, 15 and 21. On day 15, FBG level reduced appreciably by 31·49 % in rats treated with SC seed extract and by 32·28 % in rats treated with YM seed extract, comparable to metformin (30·70 %) and BGR-34 (a commercial polyherbal drug) (31·81 %) administered rats. Either extract exhibited desirable effects on hepatic glucose-6-phosphatase, glucose-6-phosphate dehydrogenase (G6PD) and catalase activities in controlling diabetes. A molecular docking exercise was conducted to identify specific compounds in the extracts which possessed augmenting effect on G6PD. The results revealed that all the bioactive compounds in the extracts have binding affinities with the enzyme and contributed to the antidiabetic efficacies of the extracts as G6PD augmenters. The effects of the extracts on insulin sensitivity and glucose uptake were investigated using non-invasive modelling by iHOMA2 software. This in vitro approach indicated that extract administration resulted in increased both insulin sensitivity of the liver and glucose uptake in the gut. The findings of the present study attest these SC-CO2 extracts of the spices as safe alternatives of metformin and BGR-34 in combating type 2 diabetes and could be safely subjected to clinical studies. These extracts could also be employed in designing proactive food supplements in mitigating the metabolic disorder.
The changing nature of paediatric otomycosis in the mid-west of Ireland
Authors: Westby D , O'Connell N , Powell J , Fenton J E 
Published: July 2020

AbstractBackgroundFungal otitis externa is prevalent in tropical and sub-tropical climates; however, over the past two decades, there has been a reported increase in the prevalence of otomycosis in paediatric patients from more temperate climates. This study aimed to review the children diagnosed with otomycosis at the University Hospital Limerick with reference to frequency, causative organism, predisposing factors and management.MethodsA retrospective review was conducted of paediatric patients from 2001 to 2015. Patients with positive fungal ear swabs and a diagnosis of otomycosis were identified.ResultsNinety-three patients were positive for candida (mean age, 5.8 years), 10 patients were positive for aspergillus (mean age, 9.1 years) and 1 patient had mixed fungal infection containing both fungi. There was a positive correlation between a diagnosis of otomycosis and prior treatment with topical fluoroquinolones (r = 0.8;p< 0.01).ConclusionThe incidence of otomycosis has been increasing since 2001, which correlates with an increase in the use of topical fluoroquinolones. Previous studies identify aspergillus as the commonest causative fungi; however, this study found that candida was the commonest isolated fungi in the paediatric population.
Computational modelling of attentional selectivity in depression reveals perceptual deficits
Authors: Grange James A. , Rydon-Grange Michelle 
Published: July 2020

AbstractBackgroundDepression is associated with broad deficits in cognitive control, including in visual selective attention tasks such as the flanker task. Previous computational modelling of depression and flanker task performance showed reduced pre-potent response bias and reduced executive control efficiency in depression. In the current study, we applied two computational models that account for the full dynamics of attentional selectivity.MethodAcross three large-scale online experiments (one exploratory experiment followed by two confirmatory – and pre-registered – experiments; total N = 923), we measured attentional selectivity via the flanker task and obtained measures of depression symptomology as well as anhedonia. We then fit two computational models that account for the dynamics of attentional selectivity: The dual-stage two-phase model, and the shrinking spotlight (SSP) model.ResultsNo behavioural measures were related to depression symptomology or anhedonia. However, a parameter of the SSP model that indexes the strength of perceptual input was consistently negatively associated with the magnitude of depression symptomatology.ConclusionsThe findings provide evidence for deficits in perceptual representations in depression. We discuss the implications of this in relation to the hypothesis that perceptual deficits potentially exacerbate control deficits in depression.
Engineering polymerases for applications in synthetic biology
Authors: Nikoomanzar Ali , Chim Nicholas , Yik Eric J. , Chaput John C. 
Published: July 2020

AbstractDNA polymerases play a central role in biology by transferring genetic information from one generation to the next during cell division. Harnessing the power of these enzymes in the laboratory has fueled an increase in biomedical applications that involve the synthesis, amplification, and sequencing of DNA. However, the high substrate specificity exhibited by most naturally occurring DNA polymerases often precludes their use in practical applications that require modified substrates. Moving beyond natural genetic polymers requires sophisticated enzyme-engineering technologies that can be used to direct the evolution of engineered polymerases that function with tailor-made activities. Such efforts are expected to uniquely drive emerging applications in synthetic biology by enabling the synthesis, replication, and evolution of synthetic genetic polymers with new physicochemical properties.
A Buddhist reconfiguration of John Hick's pluralistic hypothesis: a Madhyamaka perspective
Authors: ZHAO XUAN 
Published: July 2020

AbstractIn presenting his theory of religious pluralism, John Hick discussed the Buddhist concept ofśūnyatā, emptiness, which he regarded as functionally equivalent to his postulated noumenal Real. This article introduces Hick's pluralistic hypothesis and reviews the major criticisms of his theory. It then investigates Hick's understanding ofśūnyatā, before arguing that a Madhyamaka interpretation ofśūnyatā, within the context of the Buddhist theory of ‘two truths’, differs considerably from Hick's understanding. The article suggests that the Madhyamaka interpretation ofśūnyatācan be used to reconfigure Hick's pluralistic hypothesis, thereby avoiding the major criticisms Hickian pluralism faces, for it provides a new way of thinking about the relation between ultimate reality and the reality that we experience.
The trends and developments of L2 Japanese research in the 2010s
Authors: Mori Yoshiko , Hasegawa Atsushi , Mori Junko 
Published: July 2020

AbstractThis article updates the trends and developments of Japanese as a second language (JSL) research since Mori and Mori (2011) by reviewing nearly 200 selected empirical studies published in English or Japanese between 2010 and early 2019. The first section of this review examines the cognitive aspects of second language (L2) Japanese development, focusing on vocabulary and kanji (i.e., Chinese characters transferred into Japanese) learning, syntactic development, and the issues surrounding reading and writing. The second part investigates sociocultural issues in L2 Japanese development and use, including pragmatic development, multilingual/translingual perspectives, and multilingual youth. The third section explores the role of affective variables (primarily learner motivation) in L2 Japanese development. The last section considers various pedagogical issues, including corpus-based studies and the development of materials and resources, instructional designs and classroom studies, technology-enhanced language learning and new instructional models, critical approaches to teaching Japanese and content-based instruction. The review of these themes illuminates trends and emerging areas of interest in post-2010 L2 Japanese research inspired by current developments in applied linguistics and second language acquisition (SLA) research, as well as unique features of Japanese language and sociocultural contexts.
Application of evidence-informed deliberative processes in health technology assessment in low- and middle-income countries
Authors: Oortwijn Wija , van Oosterhout Sanne , Kapiriri Lydia 
Published: July 2020

ObjectivesEvidence-informed deliberative processes (EDPs) were introduced to guide health technology assessment (HTA) agencies to improve their processes toward more legitimate decision making. A survey among members of the International Network of Agencies for HTA (INAHTA) showed that EDPs can also be relevant for countries that have not (yet) established such an agency. Therefore, we explored to what extent low- and middle-income countries (LMIC) applied the steps and elements stipulated in the EDP framework and their need for guidance.MethodsThe survey among INAHTA members was slightly adapted to address LMIC context and sent to 416 experts identified through several HTA sources. The questions focused on contextual factors and the EDP steps (installation of an appraisal committee, selecting technologies and criteria, assessment, appraisal, communication and appeal). Data collection took place between 21 May and 1 September 2019. Descriptive statistics and qualitative analyses were used to summarize the findings.ResultsWe received sixty-six meaningful responses from experts in thirty-two LMIC. We found that contextual factors to support HTA development are overall not present or only present to some extent. Respondents indicated that guidance was needed for specific elements related to selecting technologies and criteria, assessment, appraisal, as well as communication and appeal.ConclusionsEDPs have the potential to provide steps for improving HTA processes. The results of this study can serve as a baseline measurement for future monitoring and evaluation of EDP application in the responding LMIC. This could support the countries in improving their processes and enhancing legitimate decision making when using HTA.
Prevention and control mechanism for coronavirus disease 2019 epidemic at the primary level: perspective from China
Authors: Zhang Xiaoyan , Wang Yuxuan 
Published: July 2020

Abstract
After the 2003 SARS epidemic, China started constructing a primary-level emergency response system and focused on strengthening and implementation of policies, resource allocation. After 17 years of restructuring, China's primary-level response capabilities towards public health emergencies have greatly improved. During the coronavirus disease 2019 epidemic, primary-level administrative and medical personnel, social organisations, volunteers, etc. have played a significant role in providing professional services utilising the primary-level emergency response system of 17 years. However, China's organisations did not learn their lesson from the SARS epidemic, and certain problems are exposed in the system. By analysing the experience and shortcomings of China's disease prevention and control system at the primary level, we can focus on the development of disease control systems for major epidemics in the future.
Contribution of acute-phase reaction proteins to the diagnosis and treatment of 2019 novel coronavirus disease (COVID-19)
Authors: Li Lu , Chen Changzheng 
Published: July 2020

Abstract
The emergence of 2019 novel coronavirus disease (COVID-19) is currently a global concern. In this study, our goal was to explore the changing expression levels of acute-phase reaction proteins (APRPs) in the serum of COVID-19 patients and to elucidate the immunological characteristics of COVID-19. In the study design, we recruited 72 COVID-19 patients, including 22 cases of mild degree, 38 cases of moderate degree and 12 cases of severe degree. We also recruited 20 patients with community-acquired pneumonia (CAP) and 20 normal control subjects as a comparison. Fasting venous blood was taken to detect the content of complement 3 (C3), complement 4 (C4), C-reactive protein (CRP), serum amyloid A (SAA) and prealbumin (PA). When compared the COVID-19 group with the CAP and normal control groups, respectively, the mean value of CRP and SAA in the COVID-19 group (including mild, moderate and severe patients) had increased significantly (P < 0.01), whereas the mean values of C3, C4 and PA decreased (P < 0.01). For the asymptomatic or mild symptomatic patients with COVID-19, the actual aggravation of disease may be more advanced than the clinical appearances. Meanwhile, the statistical analyses indicated that the development of COVID-19 brought about a significant increase in the content of CRP and SAA (P < 0.01), and a decline in the content of C3, C4 and PA (P < 0.01). These findings suggested that the changes in the level of APRPs could be used as indicators to identify the degree and progression of COVID-19, and the significant changes might demonstrate the aggravation of disease. This study provided a new approach to improve the clinical management plan and prognosis of COVID-19.
Geographical variation in case fatality rate and doubling time during the COVID-19 pandemic
Authors: Mazumder A. , Arora M. , Sra M. S. , Gupta A. , Behera P. , Gupta M. , Agarwal M. , Rao A. , Mohanta R. , Parameswaran G. G. , Lohiya A. , Shewade H. D. 
Published: July 2020

AbstractCase fatality rate (CFR) and doubling time are important characteristics of any epidemic. For coronavirus disease 2019 (COVID-19), wide variations in the CFR and doubling time have been noted among various countries. Early in the epidemic, CFR calculations involving all patients as denominator do not account for the hospitalised patients who are ill and will die in the future. Hence, we calculated cumulative CFR (cCFR) using only patients whose final clinical outcomes were known at a certain time point. We also estimated the daily average doubling time. Calculating CFR using this method leads to temporal stability in the fatality rates, the cCFR stabilises at different values for different countries. The possible reasons for this are an improved outcome rate by the end of the epidemic and a wider testing strategy. The United States, France, Turkey and China had high cCFR at the start due to low outcome rate. By 22 April, Germany, China and South Korea had a low cCFR. China and South Korea controlled the epidemic and achieved high doubling times. The doubling time in Russia did not cross 10 days during the study period.
Voice quality and coda /r/ in Glasgow English in the early 20th century
Authors: Sóskuthy Márton , Stuart-Smith Jane 
Published: July 2020

AbstractWe present acoustic and auditory analyses of changes to coda /r/ and voice quality in Glasgow English in the early twentieth century. Our initial acoustic analysis suggests that /r/ was weakening across the board based on an increase in F3. However, an auditory analysis of the same data finds no significant changes. An acoustic analysis of the same speakers’ vowels reveals that the shift in F3 is not unique to /r/. It reflects a change in voice quality, which we link to velarization using Vocal Profile Analysis. We then reanalyze the acoustic /r/ data, controlling for voice quality, and find only moderate changes that are restricted to females. These findings provide new evidence for diachronic changes in voice quality, contribute to our understanding of the development of /r/ in Glasgow English, and highlight the importance of investigating speech sounds in their broader context using multiple methodologies.