bluuebunny/crossref_metadata_2025_split huggingface dataset:
Height of fever and invasive bacterial infection
Authors: Michelson Kenneth A , Neuman Mark I , Pruitt Christopher M , Desai Sanyukta , Wang Marie E , DePorre Adrienne G , Leazer Rianna C , Sartori Laura F , Marble Richard D , Rooholamini Sahar N , Woll Christopher , Balamuth Fran , Aronson Paul L 
Published: August 2020

ObjectiveWe aimed to evaluate the association of height of fever with invasive bacterial infection (IBI) among febrile infants <=60 days of age.MethodsIn a secondary analysis of a multicentre case–control study of non-ill-appearing febrile infants <=60 days of age, we compared the maximum temperature (at home or in the emergency department) for infants with and without IBI. We then computed interval likelihood ratios (iLRs) for the diagnosis of IBI at each half-degree Celsius interval.ResultsThe median temperature was higher for infants with IBI (38.8°C; IQR 38.4–39.2) compared with those without IBI (38.4°C; IQR 38.2–38.9) (p<0.001). Temperatures 39°C–39.4°C and 39.5°C–39.9°C were associated with a higher likelihood of IBI (iLR 2.49 and 3.40, respectively), although 30.4% of febrile infants with IBI had maximum temperatures <38.5°C.ConclusionsAlthough IBI is more likely with higher temperatures, height of fever alone should not be used for risk stratification of febrile infants.
Prevalence and incidence rates of atrial fibrillation in Norway 2004–2014
Authors: Kjerpeseth Lars Jøran , Igland Jannicke , Selmer Randi , Ellekjær Hanne , Tveit Arnljot , Berge Trygve , Kalstø Silje Madeleine , Christophersen Ingrid Elisabeth , Myrstad Marius , Skovlund Eva , Egeland Grace Margrethe , Tell Grethe Seppola , Ariansen Inger 
Published: August 2020

ObjectiveTo study time trends in incidence of atrial fibrillation (AF) in the entire Norwegian population from 2004 to 2014, by age and sex, and to estimate the prevalence of AF at the end of the study period.MethodsA national cohort of patients with AF (≥18 years) was identified from inpatient admissions with AF and deaths with AF as underlying cause (1994–2014), and AF outpatient visits (2008–2014) in the Cardiovascular Disease in Norway (CVDNOR) project. AF admissions or out-of-hospital death from AF, with no AF admission the previous 10 years defined incident AF. Age-standardised incidence rates (IR) and incidence rate ratios (IRR) were calculated. All AF cases identified through inpatient admissions and outpatient visits and alive as of 31 December 2014 defined AF prevalence.ResultsWe identified 175 979 incident AF cases (30% primary diagnosis, 69% secondary diagnosis, 0.6% out-of-hospital deaths). AF IRs (95% confidence intervals) per 100 000 person years were stable from 2004 (433 (426–440)) to 2014 (440 (433–447)). IRs were stable or declining across strata of sex and age with the exception of an average yearly increase of 2.4% in 18–44 year-olds: IRR 1.024 (1.014–1.034). In 2014, the prevalence of AF in the adult population was 3.4%.ConclusionsWe found overall stable IRs of AF for the adult Norwegian population from 2004 to 2014. The prevalence of AF was 3.4% at the end of 2014, which is higher than reported in previous studies. Signs of an increasing incidence of early-onset AF (<45 years) are worrying and need further investigation.
Frameshift mutation of Timm8a1 gene in mouse leads to an abnormal mitochondrial structure in the brain, correlating with hearing and memory impairment
Authors: Song Pingping , Guan Yuqing , Chen Xia , Wu Chaochen , Qiao An , Jiang Haishan , Li Qi , Huang Yingwei , Huang Wei , Xu Miaojing , Niemtiah Ouattara , Yuan Chao , Li Wei , Zhou Liang , Xiao Zhongju , Pan Suyue , Hu Yafang 
Published: August 2020

BackgroundDeafness-dystonia-optic neuronopathy (DDON) syndrome is a progressive X-linked recessive disorder characterised by deafness, dystonia, ataxia and reduced visual acuity. The causative gene deafness/dystonia protein 1 (DDP1)/translocase of the inner membrane 8A (TIMM8A) encodes a mitochondrial intermembrane space chaperon. The molecular mechanism of DDON remains unclear, and detailed information on animal models has not been reported yet.Methods and resultsWe characterized a family with DDON syndrome, in which the affected members carried a novel hemizygous variation in the DDP1 gene (NM_004085.3, c.82C>T, p.Q28X). We then generated a mouse line with the hemizygous mutation (p.I23fs49X) in the Timm8a1 gene using the clustered regularly interspaced short palindromic repeats /Cas9 technology. The deficient DDP1 protein was confirmed by western blot assay. Electron microscopic analysis of brain samples from the mutant mice indicated abnormal mitochondrial structure in several brain areas. However, Timm8a1I23fs49X/y mutation did not affect the import of mitochondria inner member protein Tim23 and outer member protein Tom40 as well as the biogenesis of the proteins in the mitochondrial oxidative phosphorylation system and the manganese superoxide dismutase (MnSOD / SOD-2). The male mice with Timm8a1I23fs49X/y mutant exhibited less weight gain, hearing impairment and cognitive deficit.ConclusionOur study suggests that frameshift mutation of the Timm8a1 gene in mice leads to an abnormal mitochondrial structure in the brain, correlating with hearing and memory impairment. Taken together, we have successfully generated a mouse model bearing loss-of-function mutation in Timm8a1.
Completeness and quality of text paging for subspecialty consult requests
Authors: Chu Chi D , Tuot Delphine S , Harrison James D , Duong Jonathan , Luxenberg Adam , Khanna Raman R 
Published: August 2020

ABSTRACTIt is unclear whether previously developed frameworks for effective consultation apply to requests initiated by alphanumeric text page. We assessed a random sample of 210 text paged consult requests for communication of previously described ‘essential elements’ for effective consultation: reason for consult, level of urgency and requester contact information. Overall page quality was evaluated on a 5-point Likert scale. Over 90% of text paged consult requests included contact information and reason for consult; 14% indicated level of urgency. In ordinal logistic regression, reason for consult was most strongly associated with quality (OR 22.4; 95% CI 8.1 to 61.7), followed by callback number (OR 6.2; 95% CI 0.8 to 49.5), caller’s name (OR 5.0; 95% CI 1.9 to 13.1) and level of urgency (OR 3.3; 95% CI 1.6 to 6.7). Results suggest that text paged consult requests often include most informational elements, and that urgency, often missing, may not be as ‘essential’ for text pages as it was once thought to be.
Lung Cancer and Immunity Markers
Authors: Lim Raymond J. , Liu Bin , Krysan Kostyantyn , Dubinett Steven M. 
Published: August 2020

AbstractAn in-depth understanding of lung cancer biology and mechanisms of tumor progression has facilitated significant advances in the treatment of lung cancer. There remains a pressing need for the development of innovative approaches to detect and intercept lung cancer at its earliest stage of development. Recent advances in genomics, computational biology, and innovative technologies offer unique opportunities to identify the immune landscape in the tumor microenvironment associated with early-stage lung carcinogenesis, and provide further insight in the mechanism of lung cancer evolution. This review will highlight the concept of immunoediting and focus on recent studies assessing immune changes and biomarkers in pulmonary premalignancy and early-stage non–small cell lung cancer. A protumor immune response hallmarked by an increase in checkpoint inhibition and inhibitory immune cells and a simultaneous reduction in antitumor immune response have been correlated with tumor progression. The potential systemic biomarkers associated with early lung cancer will be highlighted along with current clinical efforts for lung cancer interception. Research focusing on the development of novel strategies for cancer interception prior to the progression to advanced stages will potentially lead to a paradigm shift in the treatment of lung cancer and have a major impact on clinical outcomes.See all articles in this CEBP Focus section, “NCI Early Detection Research Network: Making Cancer Detection Possible.”
Platelet Dysfunction and Thrombosis in JAK2
V617F
-Mutated Primary Myelofibrotic Mice
Authors: Matsuura Shinobu , Thompson Cristal R. , Belghasem Mostafa Elmokhtra , Bekendam Roelof H. , Piasecki Andrew , Leiva Orly , Ray Anjana , Italiano Joseph , Yang Moua , Merill-Skoloff Glenn , Chitalia Vipul C. , Flaumenhaft Robert , Ravid Katya 
Published: August 2020

Objective:

The risk of thrombosis in myeloproliferative neoplasms, such as primary myelofibrosis varies depending on the type of key driving mutation (JAK2 [janus kinase 2], CALR [calreticulin], and MPL [myeloproliferative leukemia protein or thrombopoietin receptor]) and the accompanying mutations in other genes. In the current study, we sought to examine the propensity for thrombosis, as well as platelet activation properties in a mouse model of primary myelofibrosis induced by JAK2
V617F
(janus kinase 2 with valine to phenylalanine substitution on codon 617) mutation.

Approach and Results:

Vav1-hJAK2
V617F
transgenic mice show hallmarks of primary myelofibrosis, including significant megakaryocytosis and bone marrow fibrosis, with a moderate increase in red blood cells and platelet number. This mouse model was used to study responses to 2 models of vascular injury and to investigate platelet properties. Platelets derived from the mutated mice have reduced aggregation in response to collagen, reduced thrombus formation and thrombus size, as demonstrated using laser-induced or FeCl
3
-induced vascular injury models, and increased bleeding time. Strikingly, the mutated platelets had a significantly reduced number of dense granules, which could explain impaired ADP secretion upon platelet activation, and a diminished second wave of activation.

Conclusions:
Together, our study highlights for the first time the influence of a hyperactive JAK2 on platelet activation-induced ADP secretion and dense granule homeostasis, with consequent effects on platelet activation properties.
Conflicting Perspectives on the Value of Neprilysin Inhibition in Heart Failure Revealed During Development of a Decision Aid Focusing on Patient Costs for Sacubitril/Valsartan
Authors: Venechuk Grace E. , Allen Larry A. , Doermann Byrd Katherine , Dickert Neal , Matlock Daniel D. 
Published: August 2020

Background:
Despite concerns about rising costs in health care, cost is rarely an issue discussed by patients and clinicians when making treatment decisions in a clinical setting. This study aimed to understand stakeholder perspectives on a patient decision aid (PtDA) meant to help patients with heart failure choose between a generic and relatively low-cost heart failure medication (ACE [angiotensin-converting enzyme] inhibitor or angiotensin II receptor blocker) and a newer, but more expensive, heart failure medication (angiotensin II receptor blocker neprilysin inhibitor).

Methods and Results:
Feedback on the PtDA was solicited from 26 stakeholders including patients, clinicians, and the manufacturer. Feedback was recorded and discussed among development team members until consensus regarding both the interpretation of the data and the appropriate changes to the PtDA was reached. Stakeholders found the PtDA sufficient in clarifying the different treatment options for heart failure. However, patients, physicians, and the manufacturer had different opinions on the importance of highlighting cost in a PtDA. Patients indicated issues of cost were crucial to the decision while physicians and manufacturers expressed that the cost issue was secondary and should be de-emphasized.

Conclusions:
The stratified perspectives on the role of cost in medical decision-making expressed by our participants underscore the importance and challenge of having clear, frank discussions during clinic visits about treatment cost and perceived value.
Excimer Laser Sheath–Assisted Retrieval of “Closed‐Cell” Design Inferior Vena Cava Filters
Authors: Desai Kush R. , Xiao Nicholas , Salem Riad , Karp Jennifer K. , Ryu Robert K. , Lewandowski Robert J. 
Published: August 2020

Background
Numerous reports have shown that inferior vena cava filters are associated with clinically significant adverse events. Complicating factors, such as caval incorporation, may lead to technical challenges at retrieval. The use of advanced techniques including the laser sheath have increased technical success rates; however, the data are limited on which filter types necessitate and benefit from its use.

Methods and Results

From October 2011 to September 2019, patients with inferior vena cava filter dwell times >6 months or with prior failed retrievals were considered for laser sheath–assisted retrieval. Standard and nonlaser advanced retrieval techniques were attempted first; if the filter could not be safely or successfully detached from the caval wall using these techniques, the laser sheath was used. Technical success, filter type, necessity for laser sheath application based on “open” versus “closed‐cell” filter design, dwell times, and adverse events were evaluated. A total of 441 patients (216 men; mean age, 54 years) were encountered. Mean dwell times for all filters was 56.6 months, 54.4 among closed‐cell filters and 58.5 among open‐cell filters (
P
=0.63). Technical success of retrieval was 98%, with the laser sheath required in 143 cases (40%). Successful retrieval of closed‐cell filters required laser sheath assistance in 60% of cases as compared with 7% of open‐cell filters (odds ratio, 20.1;
P
<0.01). In closed‐cell inferior vena cava filters, dwell time was significantly associated with need for laser, requiring it in 64% of retrievals with dwell times >6 months (
P
=0.01). One major adverse event occurred among laser sheath retrievals when a patient required a 2‐day inpatient admission for a femoral access site hemorrhage.

Conclusions
Closed‐cell filters may necessitate the use of the laser sheath for higher rates of successful and safe retrieval.
Radiation-Induced Condensational Growth and Cooling of Cloud-Sized Mist Droplets
Authors: Brewster M. Q. , Li X. , Roman K. K. , McNichols E. O. , Rood M. J. 
Published: August 2020

AbstractA laboratory-experimental and theoretical-modeling investigation was conducted of isobaric, radiative cooling of cloud-like water mists to a remote heat sink, similar to what can happen at the tops of clouds. For mist initially at 20°C cooled by a radiative sink at −20°C, the mean (D43) mist droplet diameter grew from 5.5 to 8.4 μm and the mist temperature decreased from 20° to 3°C in just 80 s. Modeling showed that conventional assumptions were able to predict the measured temperature decrease reasonably well but not droplet size changes, suggesting that bulk radiative cooling was being reasonably well modeled but not detailed, droplet-size-dependent behavior. In a theoretical analysis, Lewis-number near unity was exploited to obtain an analytic expression for quasi-steady supersaturation that agrees with what Davies reported in 1985 but is simpler and is a function of only droplet size distribution, surface tension, and solute parameters and not radiative transfer. A simpler expression for the corresponding time constant was also found that is a function of only the binary diffusion coefficient and D31 moment of the droplet diameter distribution. The time constant was found to be in milliseconds and not seconds. Simply modifying quasi-steady supersaturation (i.e., applying droplet cooling effects uniformly to all droplet sizes) was shown not to be an acceptable substitute for including droplet-specific radiation terms in the droplet growth equation. These results confirm that radiative cooling at cloud top can have a significant effect on droplet size evolution and temperature change and provide data and analytical simplifications for use in further needed investigations of radiation modeling assumptions and parameterizations.
Large-Scale Environmental Influences on Tropical Cyclone Formation Processes and Development Time
Authors: Teng Hsu-Feng , Done James M. , Lee Cheng-Shang , Hsu Huang-Hsiung , Kuo Ying-Hwa 
Published: August 2020

AbstractThe development of tropical cloud clusters (TCCs) to tropical cyclones (TCs) is the process of TC formation. This study identifies five main environmental transitions for the development of TCCs to TCs in the western North Pacific by using a cluster analysis method. Of these, three transitions indicate TCCs that develop in monsoon environments and two in easterly environments. Their numbers, distributions, and interannual variability differ. On average, the development time, defined as the period from the TCC forming to it developing into a TC, for TCCs that develop in easterly environments is shorter than that in monsoon environments. For the development of TCC to TC in easterly environments, TCCs have fewer embedded mesoscale convective systems (MCSs), which are located closer to the TCC center. Moreover, there is a stronger inward short-term (less than 10 days) angular momentum flux (AMF) at middle levels (800–500 hPa) before TCC formation. Conversely, in monsoon environments, TCCs have more MCSs, which are located farther from the TCC center. A stronger inward short-term AMF at low levels (1000–850 hPa) is observed before TCC formation and develops upward during the development of TCC to TC. The characteristics of MCS and AMF are significantly correlated with the development time of TCC to TC. In summary, large-scale easterly and monsoon environments cause TCCs to have different MCS and AMF characteristics, leading to higher efficiency for TCCs developing into TCs in easterly environments compared to monsoon environments.
Epithelioid Sarcoma of the Tongue: An Unusual Tumor Mimic for Squamous Cell Carcinoma
Authors: Kazi Aasif A. , Vahidi Nima A. , Wiles Austin B. , Reiter Evan R. 
Published: August 2020

Introduction: Epithelioid sarcoma is a rare soft tissue malignancy that usually presents in the distal extremities along fascial planes, aponeuroses or tendon sheaths. Very rarely, it presents as a primary or metastatic lesion of the head neck. Methods: Chart review and comprehensive literature review using PubMed and Google Scholar. Results: A 17-year-old non-smoker was referred for evaluation of an ulcerative lesion of the right anterior-lateral tongue, progressing over several months. Incisional biopsy was concerning for squamous cell carcinoma. He underwent partial glossectomy and bilateral selective neck dissections, with reconstruction using a radial forearm free flap. Final pathology was consistent with epithelioid sarcoma, proximal type, demonstrating perineural invasion and close margins. Post-operative PET scan showed no persistent nor metastatic disease. He underwent post-operative radiation therapy to a total dose of 56 Gy to the primary site. Conclusion: Epithelioid sarcoma is a rare malignancy usually presenting in the extremities of young adults, which uncommonly presents in the head and neck as a primary or metastatic lesion. The infrequency of these lesions has prevented development of evidence-based treatment recommendations. As with most sarcomas, surgery is the mainstay of therapy for epithelioid sarcoma, while radiation has been used in an adjunctive role. Although a rare lesion, epithelioid sarcoma should be considered in the differential diagnosis for atypical epithelioid lesions of the tongue and oral cavity when patient demographics, gross lesion characteristics, or histopathology are not entirely consistent with more common lesions, such as squamous cell carcinoma.
Caring for the Poor and Vulnerable: A Virtue Analysis of Mandated Health Insurance Compared with Healthcare Sharing Ministries
Authors: Sullivan Ezra 
Published: August 2020

In the present time, what has been called the “medical–industrial insurance complex” in the United States needs reform. As health insurance in the United States remains inaccessible to millions of people, and as prices continue to rise, questions arise about the most moral ways to ensure delivery of health care especially to the most vulnerable populations. In this essay, I offer a virtue analysis of the moral implications of health insurance mandated by the US Government in contrast to an increasingly popular alternative to insurance, namely, healthcare sharing ministries. In part 1, I list some of the moral problems entangled with US Government-mandated health insurance, including injustice, disrespect for patient autonomy, limitations on patient freedom, exploitation of patients for profit, undermining of conscience rights, cooperation with evil, and scandal. In part 2, I discuss the issue of risk and then list some potential moral advantages to healthcare ministries, including respect for patient autonomy, conscience, and the religious freedom to witness to the Catholic faith in charity and solidarity. Summary: Mandated health insurance the United States presents some moral challenges for conscientious Catholics, whereas healthcare sharing ministries appear to ameliorate some of these issues. Ultimately, the individual should have freedom to choose either insurance or healthcare sharing, given the different benefits and risks entailed by both.
Age-related features in vestibular migraine onset: A multiparametric analysis
Authors: Ori Michele , Arra Gabriele , Caricato Michela , Freccia Rocco , Frati Francesco , De Bonis Teodosio , Ricci Giampietro , Faralli Mario 
Published: August 2020

Background Clinical heterogeneity is a peculiarity of vestibular migraine, in contrast to other vestibular disorders that have a more stereotypical expression. Migraine presents a range of variability in symptoms depending on the age of the patient. Supposing that migraine headache and vestibular migraine share the same pathogenetic mechanisms, a multiparametric analysis was performed to verify the hypotheses of an age-related influence on the clinical features of vestibular migraine at the onset. Methods In this retrospective study, we analysed the clinical records of 72 consecutive patients affected by vestibular migraine from June 2012 to November 2018: 64 females and eight males; mean age 38.2 ± 9.6. We considered only patients that reported onset of vestibular symptoms within 12 months preceding inclusion into the study. Results Statistical analysis shows a significant increase in the diagnosis of probable vestibular migraine with increasing age and a decrease in vestibular migraine diagnosis ( p = 0.034). The incidence of spontaneous dizziness increases with age ( p = 0.012); by contrast, external spontaneous vertigo, and visually induced vertigo decrease after 40 years of age ( p = 0.018), clinically characterising the onset of juvenile forms. Spontaneous vertigo, head motion-induced vertigo/dizziness, and positional vertigo did not show significant variations with age. Conclusion Our data show that the type of vestibular symptoms in vestibular migraine varies according to the age of onset.