bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Endocrine Neoplasia Type 2B Associated Mixed Medullary and Follicular Thyroid Carcinoma in A Chinese Patient with RET M918T Germline Mutation
Authors: Qi Xiao-Ping , Lin Guo-Bing , Chen Bo , Li Feng , Cao Zhi-Lie , Zheng Wei-Hui , Zhao Jian-Qiang 
Published: July 2020

Background:
Mixed medullary and follicular thyroid carcinoma (MMFC) displays heterogeneous
morphological components and immunophenotypical features intermingled within the same
lesion, which is rare and most described in the sporadic form. We report herein a Chinese patient with
multiple endocrine neoplasia type 2B (MEN2B) harboring germline RET M918T and associated
MMFC.

Methods:
A case of a 39-year-old male patient with MEN2B presented palpable neck masses in both
thyroid lobes (maximum sizes: left, 3.9 cm; right, 5.4 cm) and a definitive phenotype. Serum levels of
calcitonin (Ctn; >2000pg/mL), carcinoembryonic antigen (CEA; 719.27ng/mL), and thyroglobulin
(Tg; 98.54ng/mL) were high. Fine-needle aspiration cytology showed features positive for malignancy,
suggesting the possibility of medullary thyroid carcinoma (MTC). Total thyroidectomy, along with
extending bilateral neck lymph nodes dissection, and subsequently, genetics family screening were
performed.

Results:
The histopathological examination yielded a diagnosis of MMFC that showed immunohistochemical
characteristic patterns of the component of MTC positive for Ctn and CEA, chromogranin A,
and the follicular carcinoma components were positive for Tg. Lymph node metastasis was observed
showing medullary tumoral cells positive for Ctn and follicular-like structures lacking tumor cells positive
for Tg staining (T4bN1bM0). Genetics screening confirmed RET M918T (c.2753T>C) mutation
manifested in the patient but was not detected in other family members. Follow up showed that the
serum Ctn, CEA and Tg levels respectively dropped to 54.38pg/ml, 4.16ng/mL and 0.04ng/mL 16
months after the surgery.

Conclusion:
Particular and diverse patterns of MMFC should be recognized with immunostaining
features. MMFC occurring in a patient with MEN2B harboring RET M918T may be unique biological
behavior and the treatment is mostly radical surgery.
A Retrospective Cohort Study of Histology-Proven Neuroendocrine Neoplasms in the Italian Area of Udine
Authors: Valent Francesca , Tullio Annarita , Kara Elda , Cipri Claudia , Sciannimanico Silvia M. , Vescini Fabio , Grimaldi Franco 
Published: July 2020

Aims:
The aim of this study was to investigate the epidemiology of histology-proven
Neuroendocrine neoplasms (NENs) in an Italian area.

Background:
NENs are a rare and poorly known disease and the global incidence and prevalence appear
to be increasing over the past decades.

Objective:
The objectives of this study were to estimate the incidence and trends of NENs in a
250,000-inhabitant area in the North-East of Italy in the 1998-2018 period and to compare them with
international data.

Methods:
This retrospective cohort study was based on the analysis of anonymous health administrative
databases, linked with each other at individual patient level through an anonymous stochastic key.
NENs were identified from the anatomical pathology database.

:
The standardized incidence rate (2010ESP and US2000) ± 95% CI per 100,000 were calculated, both
annually and globally, for the whole period. Incidence was also calculated for specific anatomical sites
and by gender.

:
Trends for the considered periods and sites were summarized through the annual percent change (APC)
and average increase (cases per 100,000 per year).

Results:
In the 1998-2018 period, the standardized incidence rate of NENs in the area of Udine was
2.49 (APC 3.33). A total of 162 cases were observed (51.2% males). Differences in incidence and
trend were observed between sexes. The obtained results were consistent with those reported in other
countries, confirming a significant and steady increase in NENs incidence in the last twenty years.

Conclusions:
This study provides new epidemiological data on NENs in Italy. The observed sex differences
deserve further investigations.
Designing and Developing a Questionnaire on Autistic Learning Environment
Authors: Ghazali Roslinda , Md Sakip Siti Rasidah , Samsuddin Ismail 
Published: July 2020

Designing and developing a new questionnaire as an instrument used in data collection need a longer time to establish. This paper describes the processes involved in designing and developing the questionnaire. This instrument is to measure awareness and knowledge among who involves in the autistic learning environment. The survey must be both valid and reliable. The researcher refers to the expertise to check the quality of the tool. Each expert independently evaluated the relevance, clarity, and the understandability of the instrument. The overall content of the questionnaire comprises of sensory stimulation, sensory sensitivity, sensory design, and physical learning environment. Keywords: Autism; pre-testing; questionnaire.eISSN: 2514-751X © 2020 The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ajebs.v5i16.367
Detection of Bacteremia in Surgical In-Patients Using Recurrent Neural Network Based on Time Series Records: Development and Validation Study
Authors: Park Hyung Jun , Jung Dae Yon , Ji Wonjun , Choi Chang-Min 
Published: July 2020

Background
Detecting bacteremia among surgical in-patients is more obscure than other patients due to the inflammatory condition caused by the surgery. The previous criteria such as systemic inflammatory response syndrome or Sepsis-3 are not available for use in general wards, and thus, many clinicians usually rely on practical senses to diagnose postoperative infection.

Objective
This study aims to evaluate the performance of continuous monitoring with a deep learning model for early detection of bacteremia for surgical in-patients in the general ward and the intensive care unit (ICU).

Methods
In this retrospective cohort study, we included 36,023 consecutive patients who underwent general surgery between October and December 2017 at a tertiary referral hospital in South Korea. The primary outcome was the area under the receiver operating characteristic curve (AUROC) and the area under the precision-recall curve (AUPRC) for detecting bacteremia by the deep learning model, and the secondary outcome was the feature explainability of the model by occlusion analysis.

Results
Out of the 36,023 patients in the data set, 720 cases of bacteremia were included. Our deep learning–based model showed an AUROC of 0.97 (95% CI 0.974-0.981) and an AUPRC of 0.17 (95% CI 0.147-0.203) for detecting bacteremia in surgical in-patients. For predicting bacteremia within the previous 24-hour period, the AUROC and AUPRC values were 0.93 and 0.15, respectively. Occlusion analysis showed that vital signs and laboratory measurements (eg, kidney function test and white blood cell group) were the most important variables for detecting bacteremia.

Conclusions
A deep learning model based on time series electronic health records data had a high detective ability for bacteremia for surgical in-patients in the general ward and the ICU. The model may be able to assist clinicians in evaluating infection among in-patients, ordering blood cultures, and prescribing antibiotics with real-time monitoring.
Chronic Kidney Disease in Tasmania: Protocol for a Data Linkage Study
Authors: Saunder Timothy , Kitsos Alex , Radford Jan , Jose Kim , McKercher Charlotte , Raj Rajesh , Wiggins Nadine , Stokes Brian , Jose Matthew D 
Published: July 2020

Background
Chronic kidney disease (CKD) is a significant and growing health burden globally. Tasmania has the highest state prevalence for non-Indigenous Australians and it has consistently had the lowest incidence and prevalence of dialysis in Australia.

Objective
To examine the gap between the high community prevalence of CKD in Tasmania and the low use of dialysis.

Methods
This is a retrospective cohort study using linked data from 5 health and 2 pathology data sets from the island state of Tasmania, Australia. The study population consists of any person (all ages including children) who had a blood measurement of creatinine with the included pathology providers between January 1, 2004, and December 31, 2017. This study population (N=460,737) includes within it a CKD cohort, which was detected via pathology or documentation of kidney replacement therapy (KRT; dialysis or kidney transplant). Kidney function (estimated glomerular filtration rate [eGFR]) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Individuals with 2 measures of eGFR<60 mL/min/1.73 m2, at least 90 days apart, were identified as having CKD and were included in the CKD cohort. Individuals treated with dialysis or transplant were identified from the Australia and New Zealand Dialysis and Transplant Registry.

Results
The study population consisted of 460,737 people (n=245,573 [53.30%] female, mean age 47.4 years) who were Tasmanian residents aged 18 years and older and were followed for a median of 7.8 years. During the later 5 years of the study period, 86.79% (355,622/409,729) of Tasmanian adults were represented. The CKD cohort consisted of 56,438 people (ie, 12.25% of the study population; 53.87% (30,405/56,438) female, mean age 69.9 years) followed for a median of 10.4 years with 56,039 detected via eGFR and 399 people detected via documentation of KRT. Approximately half (227,433/460,737, 49.36%) of the study population and the majority of the CKD cohort (41,448/56,438, 73.44%) had an admission episode. Of the 55,366 deaths recorded in the study population, 45.10% (24,970/55,366) had CKD.

Conclusions
Whole-of-population approaches to examine CKD in the community can be achieved by data linkage. Over this 14-year period, CKD affected 12.25% (56,438/460,737) of Tasmanian adult residents and was present in 45.10% (24,970/55,366) of deaths.

International Registered Report Identifier (IRRID)
DERR1-10.2196/20160
Solution focused therapy untuk memperbaiki pola komunikasi keluarga
Authors: Safira Tia 
Published: July 2020

Keluarga adakalanya mengalami suatu permasalahan yang terkait dengan pola komunikasi. Dampak pada permasalahan dengan pola komunikasi yang tidak sehat ini yaitu tidak ditemukannya solusi dari permasalahan yang dialami oleh keluarga karena mengalami sequence of interaction dan tidak pernah ada proses diskusi di dalamnya. Asesmen yang dilakukan pada keluarga berupa interview dan observasi kepada ayah, ibu, dan anak. Hasil asesmen menunjukkan bahwa keluarga tidak dapat membangun solusi dari masalah yang mereka hadapi. Intervensi yang diberikan adalah Solution Focused Therapy yang disusun sebanyak 6 sesi terapi. Tujuan pemberian intervensi ini agar keluarga merubah pola komunikasi mereka menjadi lebih sehat. Hasil dari pemberian intervensi ini keluarga berhasil menyusun beberapa solusi dan merubah pola komunikasi mereka.
Políticas educativas de Colombia en los planes de gobierno del siglo XIX
Authors: Zapata Gutiérrez Margarita María 
Published: July 2020

Este artículo es resultado de la investigación: Políticas educativas de Colombia en los Planes de gobierno del siglo XIX; es un estudio de enfoque histórico, que tiene el objetivo de analizar e indagar, en Constituciones, leyes, normas, decretos y perspectivas, las políticas educativas aprobadas por la jurisprudencia colombiana en los gobiernos de este periodo. Para ello, se plantea conocer, en forma cronológica, y examinar teóricamente los planes de gobierno que sentaron las bases del Sistema educativo colombiano, en un período de polarización ideológica entre los partidos políticos liberal y conservador. Este contexto político originó nueve guerras civiles, lo que avivó la pobreza del fisco, y la idea de progreso social a través de la educación, como propósito ilustrado de un Estado con una economía anacrónicamente feudal.
Un Estado cuya ingobernabilidad, control autoritario del partido de turno e injusticia social, no impidieron que, al finalizar el siglo, disminuyera la baja cobertura, calidad y equidad educativa, que dejaron la monarquía, y la Iglesia católica española después de tres siglos en el poder. Como efecto, de esta inestabilidad social, se debe esperar que los planes de gobierno, concretados en la ley, dieran fruto a un Sistema educativo moderno, con eje en la instrucción, la inspección y la administración, con aumento de la eficiencia, infraestructura, inclusión, cobertura y equidad educativa, respecto a la educación medieval española; no obstante, la realidad educativa, todavía, como hasta hoy en día, estaba lejos de ser moderna y lograr la cobertura, calidad y equidad educativa que proclamaban las consignas en los planes de gobierno.
Impact of a Student-Run Free Clinic’s Women’s Health Program on Perceived Readiness for Clinical Rotations
Authors: Fein Arielle W. , Paladine Heather L. 
Published: July 2020

Introduction: Women’s health is only briefly explored in the preclerkship medical curriculum. Volunteering in student-run free clinics (SRFCs) increases clinical confidence; such service learning could bridge the gap between limited curricular offerings and student desire for exposure to women’s health topics. This study aimed to identify weaknesses in the women’s health preclerkship curriculum, build an educational intervention, and explore SRFCs as a teaching tool.
Methods: We performed chart review of SRFC female patients to evaluate care. We held student focus groups to elicit feedback about the established curriculum. Based on this information, we devised a workshop to review practical skills. Participants attended the workshop, volunteered at SRFC, and completed surveys preintervention and at 3 months postintervention. A control group completed baseline and follow-up surveys.
Results: We invited all 151 second-year students to participate; six attended the workshop and 21 served as control. There were no baseline differences between groups regarding age, prior experience with women’s health, confidence in relevant skills, and subjective readiness for clinical rotations; the control group had more men. After the workshop, intervention participants reported increased confidence in women’s health-related skills and in readiness for the OB/GYN rotation. Gains persisted at 3 months. Three of six students in the workshop group volunteered at SRFC; three of 12 in the control group volunteered.
Conclusions: The addition of an interactive workshop to the existing preclinical curriculum on women’s health has lasting impact on subjective readiness for clinical clerkships. SRFC may be a useful addition to classroom learning. This initiative is student-led and reproducible, and could serve as an adjunct to established preclerkship curriculum.
PENGARUH PEMBELAJARAN QUANTUM BERBANTUAN PERMAINAN DALAM PEMBELAJARAN TERHADAP KEAKTIFAN DAN HASIL BELAJAR KOGNITIF IPA SISWA KELAS V
Authors: Samadhi Ni Nyoman Nitha , Riastini Putu Nanci 
Published: July 2020

This research aims is to determine the differences of activity and learning outcomes of science between groups of students who were taught by learning Quantum assisted games and groups of students who were taught not with learning Quantum assisted game to elementary school students in V grade at Gugus II Santalia, Kubutambahan district, in academic year 2016/2017. This type of research is quasi experiment, with non equivalent design post test only control group design. The population in this study is the entire class V of elementary school in gugus II Santalia. The research sample in class V elementary school number 1 Kubutambahan as experimental group and class V elementary school number 7 Kubutambahan as control group obtained by random sampling technique by way of class lottery. Analytical methods that used in this study consist of descriptive analysis and inferential analysis using the t-test (polled variance). The results showed that there was a difference of activity and learning outcomes between the experimental group and the control group. The findings are that students become more active, enthusiastic, and happy during the learning process. In addition the steps of learning Quantum help students more easily understand the material. Thus the learning of Quantum-assisted games has an effect on the activity and learning outcomes of science students of grade V in Gugus II Santalia Kubutambahan distric of academic year 2016/2017
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE TPS BERBANTUAN PETA KONSEP TERHADAP PENGUASAAN KOMPETENSI PENGETAHUAN IPA SISWA KELAS IV
Authors: Anggara I Made Citra , Ardana I Ketut , Darsana I Wayan 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui perbedaan kompetensi pengetahuan IPA antara kelompok siswa yang dibelajarkan melalui model pembelajaran kooperatif tipe TPS berbantuan peta konsep dengan kelompok siswa yang dibelajarkan melalui pembelajaran konvensional pada siswa kelas IV SD Negeri di Gugus Letkol Wisnu Denpasar Utara. Populasi penelitian adalah siswa kelas IV SD Negeri di Gugus Letkol Wisnu. Sampel penelitian adalah siswa kelas IVA SD Negeri 1 Peguyangan sebagai kelompok eksperimen dan siswa kelas IVB SD Negeri 1 Peguyangan sebagai kelompok kontrol. Pengumpulan data dilakukan dengan metode tes (tes objektif). Data dianalisis menggunakan analisis uji-t. Hasil analisis diperoleh thitung = 6,229 >ttabel = 2,000 (dk 83 taraf signifikansi 5%), sehingga H0 ditolak dan Ha diterima. Rerata kompetensi pengetahuan IPA pada kelompok eksperimen 84,10 dan kelompok kontrol 73,20. Dapat disimpulkan bahwa model pembelajaran kooperatif tipe TPS berbantuan peta konsep berpengaruh terhadap kompetensi pengetahuan IPA siswa kelas IV SD Negeri di Gugus Letkol Wisnu Kecamatan Denpasar Utara.
Pengaruh Model Pembelajaran Assure Bernuansa Lingkungan Berbantuan Media Audiovisual terhadap Hasil Belajar IPS ditinjau dari Minat Outdoor Siswa
Authors: Pransisca Ayu 
Published: July 2020

Penelitian ini bertujuan untuk menyelidiki pengaruh model pembelajaran assure bernuansa lingkungan berbantuan media audiovisual terhadap hasil belajar IPS ditinjau dari minat outdoor siswa kelas V SDN Gugus 1 Masbagik Utara Lombok Timur. Penelitian ini menggunakan pendekatan eksperimen semu dengan rancangan post test two group faktorial design. Populasi dalam penelitian ini sebanyak 143 orang siswa. Sampel penelitian ini berjumlah 76 orang siswa ditentukan dengan teknik random sampling. Data minat outdoor siswa dikumpulkan dengan kuisioner dan data hasil belajar IPS dikumpulkan dengan tes. Data dianalisis menggunakan Anava AB berbantuan SPSS 16.00 for windows. Hasil penelitian menunjukkan bahwa: 1) Terdapat perbedaan yang signifikan hasil belajar IPS antara siswa yang mengikuti pembelajaran dengan model pembelajaran Assure bernuansa lingkungan berbantuan media audiovisual dan siswa yang mengikuti pembelajaran konvensional. 2) Terdapat pengaruh interaksi yang signifikan antara model pembelajaran Assure bernuansa lingkungan berbantuan media audiovisual dan minat outdoor terhadap hasil belajar IPS siswa, 3) Pada siswa yang memiliki minat outdoor tinggi, terdapat perbedaan signifikan hasil belajar IPS antara siswa yang mengikuti pembelajaran dengan model pembelajaran Assure bernuansa lingkungan berbantuan media audiovisual dan siswa yang mengikuti pembelajaran konvensional, 4) Pada siswa yang memiliki minat outdoor rendah, tidak terdapat perbedaan signifikan hasil belajar antara siswa yang mengikuti pembelajaran dengan model pembelajaran Assure bernuansa lingkungan berbantuan media audiovisual dan siswa yang mengikuti pembelajaran konvensional.
Keefektifan Model NHT (Numbered Heads Together) Berbantu Media Sapuan Terhadap Hasil Belajar Matematika
Authors: Pahlevi Ardian , Damayani Aries Tika , . Kiswoyo 
Published: July 2020

Latar belakang yang mendorong penelitian ini adalah rendahnya hasil belajar siswa kelas I SD Negeri Tlogosari Kulon 01. Nilai hasil belajar matematika siswa kelas 1 yang masih banyak siswa tidak memenuhi KKM. Hal ini disebabkan kurangnya penggunakan model dan media pembelajaran yang memperjelas konsep-konsep abstrak dalam pembelajaran Matematika. Penelitian ini bertujuan untuk mengetahui seberapa besar keefektifan model NHT (Numbered Heads Together) berbantu media sapuan terhadap peningkatan hasil belajar siswa ranah kognitif pada mata pelajaran MATEMATIKA kelas 1 SD Negeri Tlogosari Kulon 01. Desan penelitian ini menggunakan desain One-Group Pretest-posttest. Populasi pada penelitain ini adalah seluruh siswa kelas I SD Negeri Tlogosari Kulon 01.. Teknik pengumpulan data pada penelitian ini yaitu wawancara, tes, observasi dan dokumentasi. Hasil Penelitian ini dapat disimpulkan bahwa model pembelajaran NHT (Numbered Heads Together) berbantu media sapuan terhadap hasil belajar Matematika siswa kelas 1 efektif. Hal ini dapat dilihat dari hasil rata-rata nilai posttest siswa meningkat 20,18% dari hasil nilai pretest. Selain itu diperkuat dengan hasil peritungan uji-t diperoleh sebesar 21,36193 dan sebesar 2,048 ,karena (21,36193) > (2,048) maka hal itu menunjukan bahwa uji t signifikan
Pengaruh Model Circuit Learning (CL) Terhadap Hasil Belajar Siswa pada Mata Pelajaran IPS
Authors: Dwi Husadati Siti Fatimah , Purnamasari Veryliana , Royana Ibnu Fatkhu 
Published: July 2020

Latar belakang yang mendasari penelitian ini adalah hasil belajar ulangan IPS masih dibawah KKM, yaitu dengan rata-rata 63 sehingga belum memenuhi ketuntasan 65. Hal tersebut disebabkan karena guru hanya mengunakan pendekatan Teacher Centered sehingga saat proses pembelajaran siswa belum terlihat aktif. Dari permasalahan yang ada maka diperlukan model pembelajaran yang inovatif yang mengutamakan guru sebagai fasilitator, diantaranya model Circuit Learning (CL). Desain penelitian yang digunakan peneliti yaitu eksperimen dengan jenis pra-eksperimental design tipe one-group pretest-posttest design. Sampel dalam penelitian ini diambil seluruh dari populasi yaitu siswa kelas V yang berjumlah 43 dengan mengunakan teknik sampling Nonprobability Sampling jenis yang dipilih yaitu sampling jenuh. Teknik pengumpulan data menggunakan tes, angket, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa rata-rata posttest lebih tinggi yaitu 80,3023 dibandingkan pretest sebesar 64,9302. Hal tersebut dibuktikan dari hasil uji-t dari 43 siswa diperoleh thitung = 10,3041 serta ttabel dengan db = N-1 = 43-1 = 42, dan taraf signifikan 0,05 sebesar =1,681. Karena thitung ＞ ttabel yaitu 10,3041＞1,681 maka H0 ditolak dan Ha diterima. Dapat disimpulkan bahwa ada pengaruh model pembelajaran Circuit Learning terhadap hasil belajar siswa pada mata pelajaran IPS kelas V SDN Plamongansari 01 Semarang.