bluuebunny/crossref_metadata_2025_split huggingface dataset:
Os profissionais de saúde e a prática de preceptoria na atenção básica
Authors: Ribeiro Patrícia Kecianne Costa , Firmo Wellyson da Cunha Araújo , Sousa Mércia Helena Salgado Leite , Figueiredo Ivan Abreu , Pacheco Marcos Antônio Barbosa 
Published: July 2020

Tendo em vista os grandes desafios do SUS, sobretudo em contextos de crises, a formação de seus profissionais passa a ser tema de mais alta relevância. Nesse sentido, a preceptoria é uma atividade essencial para a formação de profissionais de saúde e tem cada vez mais ocupado papel de destaque nas discussões acadêmicas, desta maneira, as práticas de preceptoria dos profissionais da Atenção Básica devem se tornar alvo da atenção dos centros formadores dos profissionais de saúde. O objetivo do trabalho foi analisar o perfil dos profissionais de saúde das Unidades Básicas do município de São Luís (MA) que exercem a prática de preceptoria na Atenção Básica e avaliar a percepção destes profissionais sobre sua prática de preceptoria e possíveis contribuições no processo de formação. Trata-se de uma pesquisa qualitativa, exploratória, descritiva, de natureza analítica. Os sujeitos envolvidos no estudo foram profissionais de saúde das Unidades Básicas que exercem ou já exerceram atividades de preceptoria há no mínimo 1 ano. A coleta de dados ocorreu por meio de entrevistas semiestruturadas e pela aplicação de questionário sociodemográfico. A análise de dados ocorreu a partir das entrevistas e questionários, sendo utilizado o critério de saturação temática. Foi possível identificar a percepção dos preceptores sobre sua prática apontando para um modelo de professor fora dos muros da escola e a importância da Atenção Básica como cenário de transformação e formação diferenciada dos futuros profissionais de saúde. A presença do estudante significa para o preceptor um estímulo ao seu próprio crescimento profissional. Foi possível também identificar a importância da Atenção Básica como cenário de formação e transformação para os futuros profissionais da área de saúde, demonstrando estar de acordo com o que é proposto nas Diretrizes Curriculares Nacionais dos cursos de graduação em saúde.
Identifikasi Caesio cuning berdasarkan Karakterisasi Morfometrik dan DNA Barcoding yang didaratkan di Pasar Ikan Muara Baru, Jakarta
Authors: Zuhdi Muhammad Fahmi , Madduppa Hawis 
Published: July 2020

Yellow-tailed fish (Caesio cuning) have morphologically similarities with Lutjanidae families, it causes ambiguity on species authentication process. The process of species identification using morphological characteristic does not provide a precise information related to the species.This study was aimed to identify the morphometric and molecular of Yellow-tailed fish (Caesio cuning) which landed on Muara Baru Fish Market, Jakarta using COI gene. A total 30 fishes were observed their nineteen morphometric characters, and 1 fish sample was taken from the fins for DNA extraction, amplification using PCR method, electrphoresis visualization, and sequensing. Sample was analyzed by MEGA 6 software. Based on morphological analysis showed that sampel are Yellow-tailed fish which part of Caesio genus and Caesionidae family. While, genetic analysis using COI gene showed has similarities with database of Genbank NCBI. It can be concluded that identification using morphological character and DNA barcoding methode showed the species belong to Yellow-tailed fish (Caesio cunning). Ikan Ekor Kuning (Caesio cuning) memiliki kemiripan morfologi dengan anggota famili Lutjanidae lainnya, hal tersebut menyebabkan kesulitan dalam proses autentikasinya. Proses identifikasi pada suatu spesies menggunakan karakteristik morfologinya belum mampu memberikan informasi yang akurat terkait spesies tersebut. Penelitian ini bertujuan untuk mengidentifikasi ikan ekor kuning (Caesio cuning) yang didaratkan di Pasar Muara Baru, Jakarta melalui kajian karakteristikmorfometrik dan DNA barcoding menggunakan marka gen COI. Total 30 ikan diamati karakter morfometriknya, dan 1 sampel ikan diambil bagian siripnya untuk dilakukan ekstraksi DNA, amplfikasi PCR, elektroforesis, sekuensing dan dianalisis menggunakan aplikasi MEGA 6. Hasil analisis morfologi menunjukkan sampel ikan berasal dari genus Caesio dan termasuk famili Caesionidae. Sedangkan berdasarkan analisis secara molekuler menggunakan marka gen COI, didapatkan hasil bahwa spesies yang diamati (Caesio cuning) memiliki kemiripan dengan database GenBank NCBI. Dapat simpulkan bahwa identifikasi secara morfologi dan DNA menunjukkan bahwa spesies yang di peroleh yaitu Ikan ekor kuning (Caesio cuning).
Penambahan Gliserol terhadap Karakteristik Bioplastik dari Komposit Pati Aren dan Glukomanan
Authors: Purnavita Sari , Subandriyo Dyionisius Yoga , Anggraeni Ayu 
Published: July 2020

Penelitian ini bertujuan untuk mengetahui pengaruh rasio glukomanan dan pati aren dengan penambahan gliserol terhadap karakteristik bioplastik yang dihasilkan. Pembuatan bioplastik dilakukan dengan mencampurkan larutan glukomanan dan larutan pati aren, selanjutnya dilakukan penambahan gliserol dan poli vinil alkohol. Campuran tersebut dipanaskan pada suhu 80°C selama 20 menit, hasil pencampuran kemudian dimasukkan cetakan dan dikeringkan dengan oven hingga menjadi lembaran, Selanjutnya bioplastik tersebut diuji karakteristiknya yang meliputi ketahanan air, tensile strength dan tensile elongation. Rasio glukomanan terhadap pati aren yaitu 1:0,5 ; 1:1 ; 1:1,5 ; dan 1:2 Serta jumlah penambahan gliserol yaitu : 0 ml dan 10 ml. Hasil penelitian menunjukkan bahwa berbagai rasio glukomanan dan pati aren dengan penambahan gliserol berpengaruh terhadap karakteristik bioplastik. Pada penambahan gliserol 0 ml (tanpa gliserol), komposit bioplastik dengan perbandingan glukomanan : pati aren sebesar 1:1 menghasilkan nilai ketahanan terhadap air yang tertinggi , nilai tensile strength yang cukup tinggi, dan morfologi yang baik, tetapi nilai tensile elongation rendah. Sedangkan pada percobaan dengan penambahan gliserol 10 ml, komposit bioplastik dengan perbandingan glukomanan : pati aren sebesar 1:1 menghasilkan nilai tensile elongatiom yang tertinggi, morfologi bagus tetapi nilai tensile strength dan ketahanan airnya rendah. Aim of this research to determine the effect of glucomannan ratio and sugar palm starch with the addition of glycerol to the bioplastic characteristics. Making of bioplastics by mixing glucomannan solution and sugar palm starch solution, then addition of glycerol and polyvinyl alcohol. The mixture is heated at 80° C for 20 minutes, the result of mixing afer that put into a mold and dried in the oven until it becomes a sheet. After that, the characteristics of the bioplastics were tested which included water resistance, tensile strength and tensile elongation. The ratio of glucomannan to sugar palm starch is 1:0.5; 1:1; 1:1,5; and 1:2 And the amount of glycerol addition are: 0 ml and 10 ml. The results showed that the ratio of sugar palm starch and glucomannan with the addition of glycerol affected the bioplastic characteristics. At the addition of glycerol 0 ml, bioplastic composites with glucomane: palm starch ratio of 1:1 produce the highest water resistance value, high tensile strength value, and good morfology but low tensile elongation value. Whereas in experiments with the addition of 10 ml of glycerol, bioplastic composites with a glucomane: palm starch ratio of 1:1 produced the highest tensile elongatiom value and good morfology result but the value of tensile strength and water resistance was low
Educational language policy in an African country: Making a place for code-switching/translanguaging
Authors: Agbozo G. Edzordzi , ResCue Elvis 
Published: July 2020

AbstractIn Ghana, plurilingual language use is the norm rather than the exception. It follows that the multilingual linguistic practices of bilingual and multilingual Ghanaians should be reflected in language planning and languages-in-education policies. The study explores the nature of Ghana’s complex sociolinguistic ecology and details the shifts in language-in-education policies from the colonial era to the present. A closer look at the policies presents two opposing models: policies that draw on monolingual ideologies involving the use of English only as a medium of instruction from pre-school to higher levels, and policies that promote a bilingual approach where Ghanaian indigenous languages and English are used concurrently in the lower grade classes (grades 1–3), with a transition to English-only instruction from grade 4 onwards. The paper argues that instabilities in languages-in-education policies occur through the effects of ideology and policy formulation that do not take into account the linguistic ecologies of different communities, or indeed, the linguistic ecology of the Ghanaian classroom. It is proposed that rigid policies can be productively modified by recognizing the reality of code-switching in classrooms and shifting focus to the creative learning possibilities that translanguaging opens up.
Lnc-PICSAR contributes to cisplatin resistance by miR-485-5p/REV3L axis in cutaneous squamous cell carcinoma
Authors: Wang Dan , Zhou Xiaoqiang , Yin Jing , Zhou Yang 
Published: July 2020

AbstractBackgroundDysregulation of long noncoding RNAs (lncRNAs) is associated with drug resistance in multiple cancers. We explored the roles of lncRNA p38 inhibited cutaneous squamous cell carcinoma-associated lincRNA (PICSAR) in cisplatin (DDP) resistance of cutaneous squamous cell carcinoma (CSCC).MethodsQuantitative real-time polymerase chain reaction (qRT-PCR) was employed to measure the expression of lnc-PICSAR, miR-485-5p and reversionless 3-like (REV3L) mRNA. The cell counting kit-8 (CCK-8) assay was conducted to evaluate DDP resistance and cell viability. The transwell assay was performed to determine cell migration and invasion. Western blot assay and immunohistochemistry (IHC) staining assay were carried out to measure protein levels. The dual-luciferase reporter assay was used to investigate the association between miR-485-5p and lnc-PICSAR or REV3L. Murine xenograft model was constructed to explore the function of lnc-PICSAR in vivo. The morphology of exosomes was analyzed by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA).ResultsLnc-PICSAR was elevated in DDP-resistant CSCC cells. Lnc-PICSAR silencing suppressed cell viability, DDP resistance, migration and invasion in DDP-resistant CSCC cells. MiR-485-5p acted as a target of lnc-PICSAR, and miR-485-5p inhibition reversed the impacts of lnc-PICSAR silencing on DDP resistance and cell progression in DDP-resistant CSCC cells. Lnc-PICSAR promoted REV3L expression via sponging miR-485-5p. Moreover, REV3L overexpression overturned the effects of lnc-PICSAR on cell progression and DDP resistance. Lnc-PICSAR knockdown suppressed DDP resistance in vivo. In addition, lnc-PICSAR was increased in the exosomes derived from CSCC patients’ serum and CSCC cells.ConclusionLnc-PICSAR enhanced DDP resistance via miR-485-5p/REV3L axis in DDP-resistant CSCC cells. Besides, exosome-mediated lnc-PICSAR might be involved in the regulation of drug resistance in CSCC.
Circ_001569 regulates FLOT2 expression to promote the proliferation, migration, invasion and EMT of osteosarcoma cells through sponging miR-185-5p
Authors: Xiao Bin , Zhang Xusheng , Li Xiaojuan , Zhao Zhipeng 
Published: July 2020

AbstractOsteosarcoma (OS) is a common malignant tumor in the world. Circular RNAs are endogenous non-coding RNAs that have been linked to the development of cancer. However, the role of circ_001569 in OS progression is still unclear. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of circ_001569, microRNA-185-5p (miR-185-5p) and flotillin-2 (FLOT2). The abilities of cell proliferation, migration and invasion were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and Transwell assays, respectively. Also, western blot analysis was performed to assess the levels of epithelial–mesenchymal transition (EMT)-related proteins and FLOT2 protein. Besides, the dual-luciferase reporter assay was used to verify the interactions among circ_001569, miR-185-5p and FLOT2. Circ_001569 expression was increased in OS tissues and cells, and its knockdown reduced the proliferation, migration, invasion and EMT of OS cells. MiR-185-5p could interact with circ_001569. Inhibition of miR-185-5p could recover the suppression effects of silenced-circ_001569 on the proliferation and metastasis of OS cells. Furthermore, FLOT2 was a target of miR-185-5p. Overexpressed FLOT2 could restore the inhibition effects of miR-185-5p mimic on the proliferation and metastasis of OS cells. Also, FLOT2 expression was regulated by circ_001569 and miR-185-5p. In addition, circ_001569 knockdown also reduced the OS tumor growth in vivo. Circ_001569 might act as an oncogene in OS progression by regulating the miR-185-5p/FLOT2 axis, which provided a reliable new approach for the treatment of OS patients.
Design of a wearable four-channel near-infrared spectroscopy system for the measurement of brain hemodynamic responses
Authors: Arivudaiyanambi Janani , Mohan Sasikala , Cherian Sunaina Mariam , Natesan Kumaravel 
Published: July 2020

Abstract
This work describes the design and development of a four-channel near-infrared spectroscopy system to detect the oxygenated and deoxygenated hemoglobin concentration changes in the brain during various motor tasks. The system uses light-emitting diodes corresponding to two wavelengths of 760 nm and 850 nm sensitive to deoxygenated and oxygenated hemoglobin concentration changes, respectively. The response is detected using a photodetector with an integrated transimpedance amplifier. The system is designed with four channels for functional near-infrared spectroscopy (fNIRS) signals acquisition. Two experiments were conducted to demonstrate the ability of the system to detect the changes in hemodynamic responses of different tasks. In the first experiment, the hemodynamic changes during motor execution and imagery of right- and left-fist clenching tasks were acquired by the developed system and validated against a standard multichannel NIRS system. In another experiment, the fNIRS signals during rest and motor execution of right-fist clenching task were acquired using the system and classified. The results demonstrate the ability of the designed system to detect the brain hemodynamic changes during various tasks. Also, the activation patterns obtained by the developed system with a minimum number of channels are on par with those obtained by the commercial system. The developed four-channel NIRS system is user-friendly and has been designed with inexpensive components, unlike the commercially available NIRS instruments that are cumbersome and expensive.
Speakers are creative, within limits — a response to Peter Uhrig
Authors: Hoffmann Thomas 
Published: July 2020

Abstract
In his contribution to the present volume, Uhrig (2020. Cognitive Semiotics 13, 1) focusses on an interesting question: When is a novel utterance considered “creative” and when is it seen as “wrong?” As I will show, Uhrig offers many important answers to this question. At the same time, I argue 1) that deliberateness is not (always) important for linguistic creativity; 2) that appropriateness requires a closer look; and 3) that frequency does not (always) play the most important role.
COVID-19: making the right diagnosis
Authors: Schiff Gordon , Mirica Maria 
Published: July 2020

Abstract
The commentary below was written by Dr. Gordon Schiff and Maria Mirica for the PRIDE (Primary Care Research in Diagnostic Errors) project, an initiative of the Betsy Lehman Center for Patient Safety and Brigham and Women's Hospital Center for Patient Safety Research and Practice with support from the Gordon and Betty Moore Foundation. It highlights some of the key issues related to diagnostic accuracy issues for COVID-19 and beyond.
Angular position control system of pneumatic artificial muscles
Authors: Takosoglu Jakub 
Published: July 2020

AbstractThis article presents a test stand used to determine the angle control of a pair of pneumatic artificial muscles PAM, which work antagonistically like natural muscles, e.g. in the human arm. The muscles were designed and produced at the Kielce University of Technology. The technical and functional parameters of the muscles were determined on the basis of experimental research. The Ziegler-Nichols method of tuning a PID controller on the basis of the step response measurement of the open system is also presented for the analysed problem. Experimental research was performed on angle control of a pair of pneumatic muscles with a PID controller.
Determination of the carbonyl index of polyethylene and polypropylene using specified area under band methodology with ATR-FTIR spectroscopy
Authors: Almond Jasmine , Sugumaar Piriya , Wenzel Margot N. , Hill Gavin , Wallis Christopher 
Published: July 2020

Abstract
The current measurement techniques described in the literature for the determination of the carbonyl index (CI) for polyolefins such as polyethylene and polypropylene were compared and contrasted. These were all found to be inconsistent or inaccurate and were not capable of differentiating significant changes in carbonyl peak evolution throughout accelerated ageing. As a consequence of these findings, a methodology, specified area under band (SAUB) is presented here to more accurately represent the CI as a general means of reporting. The increased precision in the methodology is explained and compared to other methodologies for determining CI. The SAUB method is also shown to be capable of elucidating the differences in relative extent and rates of CI for different polyolefins, exposed to the same conditions over the same time period.
Morning specimen is not representative of metabolic control in Tunisian children with phenylketonuria: a repeated cross-sectional study
Authors: Ben Abdelaziz Rim , Tangour Nizar , Ben Chehida Amel , Haj Taieb Sameh , Feki Moncef , Azzouz Hatem , Tebib Neji 
Published: July 2020

AbstractObjective and methodsTo evaluate variation of capillary phenylalanine concentrations over the day in patients treated for phenylketonuria and the reliability of the morning sample to assess metabolic control, we conducted a repeated cross-sectional study in 25 Tunisian patients on phenylalanine-low diet. For each patient, we collected nine capillary samples over the day. Phenylalanine was dosed by fluorimetry.ResultsThere was a wide variability of phenylalanine concentrations over the day (p<0.001). Compared to morning sample, phenylalanine concentration was significantly lower before lunch (p=0.038), after lunch (p=0.025), before dinner (p<0.001), after dinner (p=0.035) and at 4:00 a.m. (p=0.011). Compared to the 24 h sampling, the morning sample had a 68% to identify unbalanced patients. 60% of patients, had peak phenylalanine concentration after the morning. Half of the patients with normal morning phenylalanine concentration had low phenylalanine values over 8–20 h. Percentages of high phenylalanine concentrations over the last semester were higher in patients with poor metabolic control over the 24 h (21% ± 43 vs. 0% ± 9%); p=0.043.ConclusionA single morning sample gives an incomplete information on metabolic control in phenylketonuric patients. Using four pre-prandial samples on the day should be considered as alternative in patients with good metabolic control.
Individualized dosimetry in children and young adults with differentiated thyroid cancer undergoing iodine-131 therapy
Authors: Kumar Praveen , Damle Nishikant Avinash , Agarwala Sandeep , Dwivedi Sada Nand , Bal Chandrasekhar 
Published: July 2020

Abstract

Objectives
The amount of Iodine-131 to treat young patients with differentiated thyroid cancer (DTC) has not been established so far. The purpose of this study was to perform and compare blood dosimetry by “Hanscheid’s approach”and lesion dosimetry by “Maxon’s approach”.

Methods
Seventy-one DTC patients ≤21 years were given diagnostic activity of 74 MBq 131I followed by whole-body scan (WBS) at 2 h (pre-void), 24 h, 48 h, and ≥72 h. Pre-therapy blood and lesion dosimetry were conducted to determine the absorbed doses to blood and lesions and to predict the therapeutic activity. The administered activities were varied from 1.11–5.55 GBq of 131I depending on disease extent. Post therapy dosimetries were again performed by acquiring WBS data at 24 h, 48 h, and ≥72 h.

Results
In blood dosimetry, the difference between predicted therapy activity (PTA) and actual therapeutic activity (ATA) was statistically significant in remnant and lung lesions but insignificant in nodal metastases (p=0.287). In lesion dosimetry, the difference between PTA and ATA was statistically significant for lung metastasis patients; however, not significant in remnant (p=0.163) and nodal metastases (p=0.054). The difference between predicted and observed absorbed dose was insignificant in blood dosimetry whereas, significant in lesion dosimetry.

Conclusions
The PTA based on 0.3 Gy recommendations of Hanscheid et al. may be adequate for patients with remnant or nodal metastases but inadequate for lung metastases. Lesion dosimetry demonstrated that there is scope to decrease the 131I empiric ATA for remnant and nodal metastases; at the same time, there is scope to increase in lung metastasis patients.
Screening for celiac disease among children with overweight and obesity: toward exploring celiac iceberg
Authors: Calcaterra Valeria , Regalbuto Corrado , Manuelli Matteo , Klersy Catherine , Pelizzo Gloria , Albertini Riccardo , Vinci Federica , Larizza Daniela , Leonard Maureen M. , Cena Hellas 
Published: July 2020

Abstract

Objectives
The coexistence of celiac disease (CD) and obesity/overweight is not unusual. We investigate the prevalence and clinical presentation of CD, detected by screening, among children with excessive weight gain.

Methods
We enrolled 200 children referred for overweight/obesity to our outpatient clinic. Medical history during pregnancy and childhood and lifestyle variables were recorded. Patients were screened for CD with total immunoglobulin A (IgA), IgA anti-transglutaminase (tTG-IgA) and IgA anti-endomysial antibodies (EMA-IgA). In subjects with positive autoantibodies, esophagogastroduodenoscopy (EGDS) was performed and genetic testing for HLA DQ2 and/or DQ8 haplotypes was tested.

Results
CD positive antibodies (tTg-IgA and EMA-IgA) were detected in eight patients (4%); in all subjects CD diagnosis was confirmed by HLA-DQ2 and/or DQ8 compatibility and EGDS. No association between CD and medical history during pregnancy and childhood or lifestyle variables was noted; however, a dietary difference was identified with those testing positive for CD also reporting a lower weekly consumption of fruits and vegetables (p=0.04). Headache was reported more frequently in patients with than without CD (p=0.04). Familiar positivity for autoimmune diseases was revealed in CD patients (p=0.01).

Conclusion
CD should be considered in children with excessive weight gain. Familial predisposition to other autoimmune diseases may represent a risk factor for development of CD. Even though the relationship between headache and CD is not well defined, the patients with headache of unknown origin should be screened for CD.