bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjunctive rifampin therapy for diabetic foot osteomyelitis
Authors: Zhang Yanli , Wang Shengju , Liu Min , Yao Shasha , Fang Song , Cheng Haiping , Chen Qiu 
Published: May 2020

Abstract

Introduction:
The prevalence of diabetes continues to rise around the world. Diabetic foot is a serious complication of diabetes, and diabetic patients with diabetic foot osteomyelitis (DFO) have a fourfold increased risk of amputation, usually indicating death. Therefore, it is particularly important to seek a more effective treatment for DFO. The treatment of DFO varies from person to person, and antimicrobial therapies vary widely. A large number of clinical studies have shown that rifampicin adjuvant therapy can reduce the rate of amputation and mortality in DFO patients. However, there is no systematic summary of clinical evidence, which limits the clinical application of rifampicin. Therefore, we attempted to provide high-quality evidence for the clinical efficacy and safety of rifampin in the adjuvant treatment of DFO through this meta-analysis.

Methods:
English literature is mainly searched in Cochrane Library, PubMed, EMBASE and Web of Science, while Chinese literature is from CNKI, CBM, VIP and Wangfang databases. At the same time, we will search clinical registration tests and gray literature. Two methodologically trained researchers will read the title, abstract, and full text, and independently select qualified literature based on inclusion and exclusion criteria. Binary data is expressed as relative risk, continuous data is expressed as mean difference or standard mean difference. The final data are synthesized using a fixed effect model or a random effect model, depending on the presence of heterogeneity. In the end, the patient's amputation rate and mortality were the main research indicators. Survival rate, HbA1c, serum creatinine, changes in ulcer area, and SF-36 quality of life assessment were used as secondary indicators. We will perform a sensitivity analysis to assess the stability of the results. Then the publication bias was evaluated by funnel plot analysis and Egger test. Finally, we will use a “recommendation grading, evaluation, formulation and evaluation” system to assess the quality of the evidence. All data analysis will be meta-analyzed by the statistical software RevMan software version 5.3.

Results:
This study will provide a high-quality comprehensive report on the effectiveness and safety of rifampicin in the treatment of DFO, and our findings will be published in peer-reviewed journals.

Conclusion:
This systematic review and meta-analysis will provide a comprehensive summary and careful evaluation of rifampicin as an adjuvant treatment of DFO with a view to providing multiple options for clinical treatment of the disease.

Registration number:
is INPLASY202040084.
Effect of fire needle therapy on mild-moderate benign prostatic hyperplasia
Authors: Zhang Tao , Xun Yun-Qing , Li Bin , Wang Gui-Ling , Wang Lin-Peng , Jia Lian-Cheng , Li Wei-Guang , Liu Xue-Mei , Liu Hui-Lin , Sun Jing-Qing 
Published: May 2020

Abstract

Background:
Benign prostatic hyperplasia (BPH) is the most common non-cancerous disease of the prostate and leads to lower urinary tract symptoms in middle-aged and elderly males. Fire needle therapy could improve the lower urinary tract symptoms associated with mild-moderate BPH in clinical practice. The aim of the present pilot study is to assess the preliminary effects of fire needle therapy on mild-moderate BPH.

Methods:
The present study is a prospective parallel randomized controlled pilot trial. A total of 60 eligible participants will be randomly assigned to a treatment or control group at a 1:1 ratio. The treatment group will receive fire needle therapy and the control group will receive watchful waiting with lifestyle advice and education regarding BPH. Participants will receive intervention for 4 weeks, with a follow-up period of 4 additional weeks. Adverse events will be recorded to assess the safety and tolerability of fire needle therapy for mild-moderate BPH. The primary outcome will be the change in the International Prostate Symptom Score. The secondary outcomes will include the change in the mean number of nightly urinations, the maximum urinary flow rate, the average flow rate, and the prostate volume as measured by a B-mode ultrasound device. All outcome measures will be observed at baseline and at 4 and 8 weeks following the beginning of treatment.

Discussion:
The present study will provide evidence of the preliminary effects of fire needle therapy on mild-moderate BPH and indicate an optimal sample size for future studies.
Effect of CO2 laser for the management of primary otosclerosis
Authors: Zhang Yi-ying , Wang Jin-sheng , Zhang Shu-hua , Liu Gui-fang , Zheng Peng-ju 
Published: May 2020

Abstract

Background:
This study will explore the effect and safety of CO2 laser (COL) for the management of patients with primary otosclerosis (PO).

Methods:
The following electronic databases will be searched from inception to the present: PUBMED, EMBASE, The Cochrane Library, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, VIP, WANGFANG, and China National Knowledge Infrastructure. No language limitation will be applied. All relevant randomized controlled trials using COL to treat patients with PO will be included. Two researchers will identify studies, collect data and evaluate the risk of bias of each included study independently. Any different views between 2 researchers will be resolved by a third researcher via discussion. Data analysis will be carried out using RevMan 5.3 software.

Results:
This study will evaluate the effect and safety of COL for the treatment of PO through hearing gain, tinnitus severity, incidence of intraoperative, health-related quality of life, other morbidities, and adverse events.

Conclusion:
This study will provide evidence for the effect and safety of COL in patients with PO.

Study registration number:
INPLASY202040110.
Prognostic role of dickkopf-1 in patients with cancer
Authors: Huang Junfang , Lu Tao , Kuang Wenbing 
Published: May 2020

Abstract
As an antagonist for the WNT signal passway, dickkopf-1(DKK1) have a great important role in the occurence and development of various type cancer. The present paper performed a meta-analysis to evaluate the predictive significance of DKK1 in cancer.
To assess the relationship between the expression of DKK1 and prognostic role in human cancers, a total of 16 articals were screened from the multiple online databases (Pubmed, EMBASE, CNKI, Web of Science and Google Scholar) in our study. By using the STATA soft,pooled hazard ratio and 95% confidence intervals of overall survival (OS), progression-free survival, disease-free survival and time to recurrence were used to evaluate the strength of this relationship.
The meta-analysis showed that higher expression of DKK1 was significantly associated with shorter OS in cancer patients. In stratified analyzes, the higher expression of DKK1 could reduced the OS in patients with breast cancer,digestive system cancer and urogenital system cancer, but not patients with the lung cancer. It also showed that higher expression of DKK1 was significantly associated with shorter progression-free survival, disease-free survival and time to recurrence in cancer patients.
The present study indicate that higher expression of DKK1 predict an unfavorable clinical outcome in patients with breast cancer, digestive system cancer and urogenital system cancer.
Clindamycin-induced acute generalized exanthematous pustulosis
Authors: Aiempanakit Kumpol , Apinantriyo Benjawan 
Published: May 2020

Abstract

Rationale:
Acute generalized exanthematous pustulosis (AGEP) is a severe pustular cutaneous adverse drug reaction. Sterile, non-follicular pustules overlying the erythematous skin characterize this reaction.

Patient concerns:
A 30-year-old Asian women presented with sterile, non-follicular lesions with pus-fluid levels on her back 2 days after taking clindamycin. Skin biopsy revealed a spongiotic change in the epidermis with a focal subcorneal pustule and perivascular eosinophil and lymphocyte infiltration.

Diagnosis:
Clindamycin-induced AGEP.

Interventions:
We discontinued clindamycin treatment and prescribed systemic corticosteroids.

Outcomes:
The pustule stopped spreading within 1 day and the rash improved within 2 days.

Lessons:
AGEP is a pustular cutaneous adverse drug reaction that can appear with pus-fluid levels, clinically mimicking Sneddon–Wilkinson disease. The differentiation between both conditions is a history of drug use, characteristic skin lesions and histopathology.
Thyroglossal duct lipoma
Authors: Tsai Ming-Shao , Chang Geng-He , Chuang Huei-Chieh , Lin Wan-Ni , Tsai Yao-Te 
Published: May 2020

Abstract

Rationale:
Thyroglossal duct cyst (TGDC), the most common midline neck mass, has several histological diagnoses other than cyst in the literature. We present the first case of thyroglossal duct lipoma.

Patient concerns:
A 63-year-old woman presented with a painless soft midline neck mass for more than 3 years, which enlarged in size and caused a lump sensation during swallowing.

Diagnoses:
Sonography revealed a 3.5 × 3.0 × 3.0-cm3 homogenous isoechoic oval lesion without an acoustic shadow beyond the thyroid glands. An ultrasound-guided biopsy revealed abundant sheets of fat cells with infiltration of some lymphocytes and histiocytes. Computed tomography revealed a 3.5 × 3.0 × 3.0-cm3 well-circumscribed ovoid mass with Hounsfield unit (HU) between −50 and −100 and a thyroglossal duct remnant. All these findings supported the diagnosis of thyroglossal duct lipoma.

Interventions:
The patient underwent Sistrunk operation for excision of the neck tumor, and pathological examination revealed an adipose tumor surrounded by benign thyroid tissue, confirming the diagnosis of thyroglossal duct lipoma.

Outcomes:
Neither postoperative complication nor recurrence was noted at the 18-month follow-up.

Lessons:
This is the first case of thyroglossal duct lipoma in the literature. Our study extends the disease spectrum of thyroglossal duct mass and suggests that clinicians should consider thyroglossal duct lipoma in the differential diagnosis of a midline neck mass.
Therapeutic effect of high-flow nasal cannula on severe COVID-19 patients in a makeshift intensive-care unit
Authors: Lu Xiao , Xu Shanxiang 
Published: May 2020

Abstract

Introduction:
Several intensive-care units (ICUs) in Wuhan are nonstandard wards that were repurposed from general wards. Considering the shortage of medical resources and the need to prevent nosocomic infection, the respiratory-treatment strategy in these nonstandard ICUs is different from those in general wards and standard ICUs. High-flow nasal cannula (HFNC) plays an important role in nonstandard ICUs and is beneficial to the patients therein.

Patient concerns:
In this study, we analyzed four cases of HFNC-treated patients with severe coronavirus disease 2019 (COVID-19) in a makeshift ICU and summarized our experience.

Diagnoses:
Four patients diagnosed with COVID-19 according to World Health Organization (WHO) interim guidance were admitted to the makeshift ICU.

Interventions:
All patients had oxygen treatment with HFNC, as well as regular treatment of antivirals and traditional Chinese medicine.

Outcomes:
Two patients survived after treatment, while the other two died from acute respiratory distress syndrome (ARDS) and heart failure, respectively.

Conclusion:
Patients with severe and critical COVID-19 often have poor prognoses after mechanical ventilation, exhibiting corresponding complications such as ventilator-associated pneumonia and deep-vein thrombosis, which significantly prolongs length of stay in the ICU. HFNC could prevent intubation in some patients, thereby avoiding the above complications; however, this needs confirmation in further clinical studies. This treatment reduced difficulty and workloads for healthcare professionals, had good tolerability for patients, might not significantly increase the risk of infection for healthcare professionals, and do not require additional preventive measures against nosocomic infection. HFNC treatment has its advantages in providing oxygen therapy in COVID-19, but healthcare professionals should still pay close attention to changes in patients’ oxygenation rates and respiratory frequency.
Long-term remissions of young patients with high-risk follicular lymphoma after first-line autologous stem cell transplantation
Authors: Lyu Rui , Wang Tingyu , Zou Dehui , Liu Wei , Yi Shuhua , Huang Wenyang , An Gang , Xu Yan , Li Zengjun , Qiu Lugui 
Published: May 2020

Abstract

Rationale:
Autologous stem cell transplantation (ASCT) is not routinely recommended as first-line choice for follicular lymphoma (FL). However, we actually have observed that young patients with extremely high-risk factors benefit from ASCT. This study aims to speculate the rationality of ASCT as first-line treatment, through 3 cases and review of the literature.

Patient concerns:
3 young-adult patients with FL received ASCT as first-line treatment.

Diagnosis:
All the 3 patients were no more than 30 years old and the diagnosis of FL was confirmed by histopathological and immunohistochemical evaluations. They all had multi-organ involvements, and two of them presented with a “leukemic-like” manifestation. Compared with those in the previous literatures, the 3 patients were relatively younger and had more invasive clinical features.

Interventions:
The 3 patients received combined chemotherapy plus rituximab, followed by first-line ASCT.

Outcomes:
All the 3 patients got complete remission and minimal residual disease negativity after ASCT, The median follow-up time was 109 (97–117) months, and all of them were in remission more than 8 years after transplant.

Lessons:
Guidelines for FL are mainly based on elderly patients, but are not suitable enough for all, especially for the young FL patients. For young patients with certain high-risk FL, first-line ASCT does not go against the guidelines, and should be recommended individually.
Hypertension and selected indicators of health assessment in a population of 19-year-old men subject to military qualifications
Authors: Chmiel Zdzisława , Żal Marcin , Więch Paweł , Bazaliński Dariusz , Sałacińska Izabela , Bartusik-Aebisher Dorota , Binkowska-Bury Monika 
Published: May 2020

Abstract
Assessment the prevalence of hypertension and its relation to selected indicators of health status and performance, including classification of BMI, obesity classifications, and body structure in a large test group of 19-year-old men.
The study was observational-retrospective, and included a group of 17,282 men, aged 19, from the Małopolska region. All subjects met the qualifications for compulsory military service in 2017. We analyzed selected data obtained from the records of the Ministry of National Defense-spiral-ZINT. Data collection and analysis were carried out from April 1, 2018 to August 31, 2018.
Hypertension was found at 0.6%, weak body structure at 0.8% and obesity
co-existing with cardiorespiratory insufficiency has been reported 2.6% of respondents and it was more frequent in the recruiters from HT II0 than I0. The underweight concerned almost 7%, and the overweight and obesity of 1/4 of conscripts. The vast majority of people with hypertension were characterized by excessive body weight (74.8%), mainly overweight.
Hypertension was seen in a negligible percentage of males studied and was significantly associated with an increase in BMI, particularly with regards to being overweight.
Simple resistance exercise decreases cytokeratin 18 and fibroblast growth factor 21 levels in patients with nonalcoholic fatty liver disease
Authors: Takahashi Atsushi , Abe Kazumichi , Fujita Masashi , Hayashi Manabu , Okai Ken , Ohira Hiromasa 
Published: May 2020

Abstract
Cytokeratin 18 (CK18) and fibroblast growth factor 21 (FGF21) are elevated in patients with nonalcoholic fatty liver disease (NAFLD) and are useful markers for identifying or monitoring outcomes. Exercise therapy is one of the established treatments for NAFLD; however, few studies have investigated the effectiveness of exercise therapy on CK18 and FGF21 levels. Therefore, the aim of the present study was to assess the effects of 12 weeks of simple resistance exercise on CK18 and FGF21 levels in patients with NAFLD.
Fifty patients with NAFLD were assigned to a resistance exercise group (n = 23) or a control group (n = 27) for a trial period of 12 weeks. During the study, the resistance exercise group performed two exercises (push-ups and squats) three times a week on nonconsecutive days, whereas the control group proceeded with regular physical activities under a restricted diet. We then compared serum levels of CK18 fragments (M65) and FGF21 between groups just before and after the 12-week period.
Serum M65 levels (880.0 ± 503.6 vs 648.9 ± 450.2 U/L; P < .01) were significantly decreased in the exercise group. However, no significant differences were observed in body mass index or skeletal muscle. The decreases in serum M65 (−231.1 ± 354.7 vs 56.2 ± 375.0 U/L; P = .02), and FGF21 levels (−41.7 ± 98.2 vs. 33.2 ± 127.6 pg/mL; P = .03) were significantly greater in the exercise than in the control group. Changes in M65 levels in the exercise group were significantly correlated with changes in alanine aminotransferase levels (r = 0.618, P < .01).
Simple resistance exercise reduced CK18 and FGF21 levels in patients with NAFLD. These findings suggest that resistance exercise consisting of push-ups and squats helps prevent the progression of NAFLD.
Efficacy and safety of acupuncture therapy for COVID-19: Retracted
Authors: Huang Shaolei , Wang Suyao , Wang Mengmeng , Rong Jiao , Yu Wenjie , Li Jing , Han Jing , Yang Dianhui 
Published: May 2020

Abstract

Background:
The study aims to evaluate the effectiveness and safety of acupuncture therapy for coronavirus disease 2019.

Methods:
The following electronic databases will be searched from December 2019 to December 2020: Medline, PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, Wan-fang database, Chinese Scientific Journal Database, Chinese Biomedical Literature Databases, and other databases. All published randomized controlled trials about this topic will be included. Two independent researchers will operate article retrieval, duplication removing, screening, quality evaluation, and data analyses by Review Manager (V.5.3.5). Meta-analyses, subgroup analysis, and/or descriptive analysis will be performed based on the included data conditions.

Results:
High-quality synthesis and/or descriptive analysis of current evidence will be provided from mortality rate, cure rate, the time of negative nucleic acid detection for 2 consecutive times (not on the same day), improvement of chest CT scans, disappearance time of fever and cough, and side effects.

Conclusion:
This study will provide the evidence of whether acupuncture is an effective and safe intervention for coronavirus disease 2019	.
PROSPERO registration number: CRD42020179298.
Association analysis between vitamin D level and depression in women perimenopause
Authors: Yuan Jie , Chen Tiantian , Lei Yaling , Wei Shujun , Yu Penglong , Cao Yue , Zhao Yuan , Chen Jie 
Published: May 2020

Abstract

Background:
In recent decades, many researches manifested that the perimenopause is a window of vulnerability for the development of both depressive symptoms and major depressive episodes. Some scholar thought that those women diagnosed with depression may be particularly sensitive to changes in the hormonal milieu experienced premenstrual, during the postpartum period or during the menopause transition in. Risk factors for depressive symptoms during the perimenopause include prior standardized mean difference (MDD), psychosocial factors, anxiety symptoms, and reproductive-related mood disturbance. However, active vitamin D (VD), exerts protective and regulatory effects on the brain dopamine system and suggests that similar to the antidepressant. Therefore, serum 25(OH)D level may be negatively correlated with the perimenopausal depression.

Methods:
The study only selects clinical randomized controlled trials of depression in perimenopausal women. We will search each database from the built-in until October 2020. The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science. While the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Meanwhile, we will retrieve clinical trial registries and grey literature. Two researchers worked independently on literature selection, data extraction, and quality assessment. The dichotomous data is represented by relative risk, and the continuous is expressed by mean difference or standard mean difference, eventually the data is synthesized using a fixed effect model or a random effect model depending on the heterogeneity. The serum vitamin D level, Hamilton Depression Scale, or Beck Depression Inventory or Zung self-rating depression scale or patient health questionnare-9 were evaluated as the main outcomes. While several secondary outcomes were also evaluated in this study. The statistical analysis of this Meta-analysis was conducted by RevMan software version 5.3.

Results:
This meta-analysis will further determine the association analysis between VD level and depression in women perimenopause.

Conclusion:
This study determines the VD level is related to the occurrence of depression in perimenopausal women.
Bibliometric and visualized analysis of global research on fungal keratitis from 1959 to 2019
Authors: Cen Yujie , Li Yingyu , Huang Chen , Wang Wei 
Published: May 2020

Abstract

Background:
Fungal keratitis is one of the leading causes of ocular morbidity. The prognosis of fungal keratitis is poorer than many other forms of keratitis but the research of which relatively lags behind. We conducted a bibliometric and visualized analysis in order to characterize the overall status, general trends and current foci of keratomycosis research field.

Methods:
Literature database ranged from 1959 to 2019 was obtained from web of science core collection and analyzed by Citespace and VOSviewer software.

Results:
A total of 1906 papers of fungal keratitis were retrieved and derived a 27,917 references document set. The number of publications increased rapidly in past 30 years. Cornea was the journal published most papers of keratomycosis. The leading countries were United States of America (USA), India and Peoples Republic of China (PRC), from where came the most productive and most cited institutions and authors. Co-cited reference analysis revealed the most cited manuscripts were concerned about epidemiology or spectrum. Lens-associated Fusarium, amphotericin B, voriconazole, corneal cross-linking, predisposing factor are some of the high frequency topics in clustered co-cited reference analysis and co-occurrence keywords analysis. Burst detection analysis of keywords showed ocular drug delivery was the new research foci.

Conclusion:
From this study, we received an overall view to the current status, trends and hot spots of fungal keratitis research field. Visualized bibliometric analysis is an efficient way for literature learning and useful for future researchers.