bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of a flexible versus rigid bone cement injection system in unilateral percutaneous vertebroplasty
Authors: Li Yuwei , Cui Wei , Zhou Peng , Li Cheng , Wen Yan , Xiao Wei 
Published: August 2020

Abstract
Background
Percutaneous vertebroplasty (PVP) has been demonstrated to be effective in the treatment of acute osteoporotic vertebral fracture (AOVF). However, bilateral puncture takes more time to accept more X-ray irradiation; some scholars apply unilateral puncture PVP, but the cement cannot be symmetrically distributed in the vertebral body, so we use a flexible cement injector that undergoes PVP through the unilateral pedicle puncture. This research aims to compare the clinical results of PVP for AOVF with unilateral pedicle puncture using a straight bone cement injector and a bendable cement injector, determine the value of a bendable cement injector.

Methods
We undertook a retrospective analysis of patients with thoracic and lumbar compression fracture treated with unilateral pedicle puncture percutaneous vertebroplasty from our institution from June 2013 to July 2015. Operation time, radiation exposure, bone cement injection amount, and the incidence of bone cement leakage were recorded on presentation, the cement leakage was measured by X-ray and computed tomography scan. The patients were followed up postoperatively and were assessed mainly with regard to clinical and radiological outcomes.

Results
There was no significant difference in the operation time, radiation exposure time and incidence of bone cement leakage between the two groups. There was significant difference in the amount of bone cement injection and the difference between the two groups. There were no significant differences in VAS and the relative height of the vertebral body and local Cobb angle and QUALEFFO between the two groups at 1 week after PVP, significant difference was observed only 12 months after operation.

Conclusions
Application of flexible cement injector is safe and feasible, compared with the application of straight bone cement injector, without prolonging the operative time, radiation exposure time and the incidence of bone cement leakage; it has the advantages of good long-term effect and low incidence of vertebral fracture recurrence.
Risk factors and outcome of COVID-19 in patients with hematological malignancies
Authors: Piñana José Luis , Martino Rodrigo , García-García Irene , Parody Rocío , Morales María Dolores , Benzo Gonzalo , Gómez-Catalan Irene , Coll Rosa , De La Fuente Ignacio , Luna Alejandro , Merchán Beatriz , Chinea Anabelle , de Miguel Dunia , Serrano Ana , Pérez Carmen , Diaz Carola , Lopez José Luis , Saez Adolfo Jesús , Bailen Rebeca , Zudaire Teresa , Martínez Diana , Jurado Manuel , Calbacho María , Vázquez Lourdes , Garcia-Cadenas Irene , Fox Laura , Pimentel Ana I. , Bautista Guiomar , Nieto Agustin , Fernandez Pascual , Vallejo Juan Carlos , Solano Carlos , Valero Marta , Espigado Ildefonso , Saldaña Raquel , Sisinni Luisa , Ribera Josep Maria , Jimenez Maria Jose , Trabazo Maria , Gonzalez-Vicent Marta , Fernández Noemí , Talarn Carme , Montoya Maria Carmen , Cedillo Angel , Sureda Anna ,   Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)
Published: August 2020

AbstractBackgroundPrognostic factors of poor outcome in patients with hematological malignancies and COVID-19 are poorly defined.Patients and methodsThis was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confirmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020.ResultsWe included 367 pediatric and adult patients with hematological malignancies, including recipients of autologous (ASCT) (n = 58) or allogeneic stem cell transplantation (allo-SCT) (n = 65) from 41 hospitals in Spain. Median age of patients was 64 years (range 1–93.8). Recipients of ASCT and allo-SCT showed lower mortality rates (17% and 18%, respectively) compared to non-SCT patients (31%) (p = 0.02). Prognostic factors identified for day 45 overall mortality (OM) by logistic regression multivariate analysis included age > 70 years [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2–3.8, p = 0.011]; uncontrolled hematological malignancy (OR 2.9, 95% CI 1.6–5.2, p < 0.0001); ECOG 3–4 (OR, 2.56, 95% CI 1.4–4.7, p = 0.003); neutropenia (< 0.5 × 109/L) (OR 2.8, 95% CI 1.3–6.1, p = 0.01); and a C-reactive protein (CRP) > 20 mg/dL (OR 3.3, 95% CI 1.7–6.4, p < 0.0001). In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids was associated with lower OM (OR 0.42, 95% CI 0.2–0.89 and OR 0.31, 95% CI 0.11–0.87, respectively, p = 0.02) whereas the use of hidroxycloroquine did not show significant improvement in OM (OR 0.64, 95% CI 0.37–1.1, P = 0.1).ConclusionsIn most patients with hematological malignancies COVID-19 mortality was directly driven by older age, disease status, performance status, as well as by immune (neutropenia) parameters and level of inflammation (high CRP). Use of azithromycin and low dose corticosteroids may be of value in very severe COVID-19.
Music performance anxiety from the challenge and threat perspective: psychophysiological and performance outcomes
Authors: Guyon Amélie J. A. A. , Studer Regina K. , Hildebrandt Horst , Horsch Antje , Nater Urs M. , Gomez Patrick 
Published: August 2020

Abstract
Background
Although many musicians perceive music performance anxiety (MPA) as a significant problem, studies about the psychobiological and performance-related concomitants of MPA are limited. Using the biopsychosocial model of challenge and threat as theoretical framework, we aim to investigate whether musicians’ changes in their psychobiological responses and performance quality from a private to a public performance are moderated by their general MPA level. According to the challenge and threat framework, individuals are in a threat state when the perceived demands of a performance situation outweigh the perceived resources, whereas they are in a challenge state when the perceived resources outweigh the perceived demands. The resources-demands differential (resources minus demands) and the cardiovascular challenge-threat index (sum of cardiac output and reverse scored total peripheral resistance) are the main indices of these states. We postulate that the relationship between general MPA level and performance quality is mediated by these challenge and threat measures.

Methods
We will test 100 university music students reporting general MPA levels ranging from low to high. They will perform privately (i.e., without audience) and publicly (i.e., with an audience) on two separate days in counterbalanced order. During each performance session, we will record their cardiovascular and respiratory activity and collect saliva samples and self-reported measures. Measures of primary interest are self-reported anxiety, the resources-demands differential, the cardiovascular challenge-threat index, sigh rate, total respiratory variability, partial pressure of end-tidal carbon dioxide and the salivary biomarkers cortisol, dehydroepiandrosterone, and alpha-amylase. Both, the participants and anonymous experts will evaluate the performance quality from audio recordings.

Discussion
The results of the planned project are expected to contribute to a more comprehensive understanding of the psychobiology of MPA and of the processes that influence musicians’ individual reactions to performance situations. We also anticipate the findings of this project to have important implications for the development and implementation of theory-based interventions aimed at managing musicians’ anxiety and improving performance quality. Thanks to the use of multimethod approaches incorporating psychobiology, it might be possible to better assess the progress and success of interventions and ultimately improve musicians’ chance to have a successful professional career.

Trial registration
Not applicable.
A recurrent mutation of GJB6 in a big Chinese family with Hidrotic ectodermal dysplasia
Authors: Zhan Yi , Luo Shuaihantian , Pi Zixin , Zhang Guiying 
Published: August 2020

AbstractHidrotic ectodermal dysplasia (HED) is a rare inherited syndrome characterised by nail dystrophy, palmoplantar hyperkeratosis and alopecia. Four mutations (p.G11R, p.A88V, p.V37E and p.D50N) in gap junction beta 6 (GJB6) gene, which codes connexin30 protein, have been found to cause HED in different populations. Here, we reported a big Chinese family in which 24 patients over five generations were suffered with HED. Sequence analysis identified all 24 patients carry a recurrent missense mutation c.263C > T (p.A88V) in GJB6. Our results reveal gene testing of GJB6 is important for diagnosis, prenatal diagnosis and future gene treatment of HED.
QTL and genetic analysis controlling fiber quality traits using paternal backcross population in upland cotton
Authors: MA LingLing , SU Ying , NIE Hushuai , CUI Yupeng , CHENG Cheng , IJAZ Babar , HUA Jinping 
Published: August 2020

Abstract
Background
Genetic improvement in fiber quality is one of the main challenges for cotton breeders. Quantitative trait loci (QTL) mapping provides a powerful approach to dissect the molecular mechanism in fiber quality traits. In present study, F14 recombinant inbred line (RIL) population was backcrossed to paternal parent for a paternal backcross (BC/P) population, deriving from one upland cotton hybrid. Three repetitive BC/P field trials and one maternal backcross (BC/M) field trial were performed including both two BC populations and the original RIL population.

Results
In total, 24 novel QTLs are detected for fiber quality traits and among which 13 QTLs validated previous results. Thirty-five QTLs in BC/P populations explain 5.01%–22.09% of phenotype variation (PV). Among the 35 QTLs, 23 QTLs are detected in BC/P population alone. Present study provides novel alleles of male parent for fiber quality traits with positive genetic effects. Particularly, qFS-Chr3–1 explains 22.09% of PV in BC/P population, which increaseds 0.48 cN·tex− 1 for fiber strength. A total of 7, 2, 8, 2 and 6 QTLs explain over 10.00% of PV for fiber length, fiber uniformity, fiber strength, fiber elongation and fiber micronaire, respectively. In RIL population, six common QTLs are detected in more than one environment: qFL-Chr1–2, qFS-Chr5–1, qFS-Chr9–1, qFS-Chr21–1, qFM-Chr9–1 and qFM-Chr9–2. Two common QTLs of qFE-Chr2–2 (TMB2386-SWU12343) and qFM-Chr9–1 (NAU2873-CGR6771) explain 22.42% and 21.91% of PV. The region between NAU4034 and TMB1296 harbor 30 genes (379 kb) in A05 and 42 genes (49 kb) in D05 for fiber length along the QTL qFL-Chr5–1 in BC/P population, respectively. In addition, a total of 142 and 46 epistatic QTLs and QTL × environments (E-QTLs and QQEs) are identified in recombinant inbred lines in paternal backcross (RIL-P) and paternal backcross (BC/P) populations, respectively.

Conclusions
The present studies provide informative basis for improving cotton fiber quality in different populations.
Facile preparation of hierarchical porous polydopamine microspheres for rapid removal of chromate from the wastewater
Authors: Xiang Lin , Lin Jiayou , Yang Qin , Lin Shaojian , Chen Sheng , Yan Bin 
Published: August 2020

Abstract
Cr(VI) containing industrial wastewaters are highly toxic and carcinogenic, and severely threats living creatures and the environment. Therefore, it is highly desired yet challenging to develop an available and economical adsorbent for simultaneously detoxifying Cr(VI) anions to Cr(III) ions and removing them from the wastewater. Here we propose a facile method for rapid removal of Cr(VI) ions from the wastewater by using a synthetic polydopamine microsphere (PPM) adsorbent with hierarchical porosity. The as-prepared PPM exhibits high Cr(VI) removal capacity of 307.7 mg/g and an outstanding removal efficiency. They can effectively decrease the Cr(VI) concentration to lower than 0.05 mg/L well below the limits for drinking water standard of WHO regulations in 60 s at pH 2. More importantly, PPMs can reduce the lethal Cr(VI) anions to Cr(III) ions with low toxicity, and simultaneously immobilize them on the matrices of PPMs.

Graphical abstract
Chitin synthase localization in the diatom Thalassiosira pseudonana
Authors: Wustmann Martin , Poulsen Nicole , Kröger Nils , van Pée Karl-Heinz 
Published: August 2020

AbstractChitin constitutes an abundant component in many biologically formed minerals (biominerals). While the role of chitin for the formation and properties of calcium-based biominerals has been extensively studied, little is known about its role in silica-based biominerals. Furthermore, there is hardly any information about the enzyme machinery for chitin biosynthesis in biomineral-forming organisms. Here we have identified a chitin synthase, chs7305, in the diatomThalassiosira pseudonana. In stationary cells, chs7305 is located specifically in a ring pattern in the region of the silicified girdle bands. The expression pattern of the chs7305 gene and the co-localization of the encoded enzyme with chitin provides evidence for the importance of chitin synthesis for cell wall function under nutrient limited conditions. Chs7305 is the first chitin synthase that has been localized in a diatom.
An exploration of psychopathology for clinical practice
Authors: Sanati Abdi 
Published: August 2020

SUMMARYPsychopathology is an integral part of the theory and practice of psychiatry. This commentary explores the importance of psychopathology, especially with regard to clinical practice. The concept of lifeworld is introduced as an important component of attributing meaning to a person's experience of mental disorder. It is also argued that the advance of neuroscience does not preclude the importance of psychopathology.
The importance of embedding psychopathology and phenomenology in clinical practice and training in psychiatry
Authors: Chakraborty Nandini 
Published: August 2020

SUMMARYPsychiatrists live and work in complex, clinically challenging times. Their paperwork is geared increasingly towards defensive practice, key performance indicators and risk assessment forms. Somewhere in the process, detailed understanding of patient experience and clinical formulation based on key psychiatric expertise and skill in mental state examination have taken a backseat. I review the history behind the Present State Examination, the realisation in the 1980s of the need for a common psychiatric language internationally and the current position on phenomenology in psychiatry curricula in the UK. I conclude that it is time to think seriously about a return to basics in psychiatric phenomenology and psychopathology.
Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial
Authors: Meattini Icro , Marrazzo Livia , Saieva Calogero , Desideri Isacco , Scotti Vieri , Simontacchi Gabriele , Bonomo Pierluigi , Greto Daniela , Mangoni Monica , Scoccianti Silvia , Lucidi Sara , Paoletti Lisa , Fambrini Massimiliano , Bernini Marco , Sanchez Luis , Orzalesi Lorenzo , Nori Jacopo , Bianchi Simonetta , Pallotta Stefania , Livi Lorenzo 
Published: August 2020

PURPOSE To report the long-term results of external-beam accelerated partial-breast irradiation (APBI) intensity-modulated radiation therapy (IMRT) Florence phase III trial comparing whole-breast irradiation (WBI) to APBI in early-stage breast cancer. PATIENTS AND METHODS The primary end point was to determine the 5-year difference in ipsilateral breast tumor recurrence (IBTR) between 30 Gy in 5 once-daily fractions (APBI arm) and 50 Gy in 25 fractions with a tumor bed boost (WBI arm) after breast-conserving surgery. RESULTS Five hundred twenty patients, more than 90% of whom had characteristics associated with low recurrence risk, were randomly assigned (WBI, n = 260; APBI, n = 260) between 2005 and 2013. Median follow-up was 10.7 years. The 10-year cumulative incidence of IBTR was 2.5% (n = 6) in the WBI and 3.7% (n = 9) in the APBI arm (hazard ratio [HR], 1.56; 95% CI, 0.55 to 4.37; P = .40). Overall survival at 10 years was 91.9% in both arms (HR, 0.95; 95% CI, 0.50 to 1.79; P = .86). Breast cancer–specific survival at 10 years was 96.7% in the WBI and 97.8% in the APBI arm (HR, 0.65; 95% CI, 0.21 to 1.99; P = .45). The APBI arm showed significantly less acute toxicity ( P = .0001) and late toxicity ( P = .0001) and improved cosmetic outcome as evaluated by both physician ( P = .0001) and patient ( P = .0001). CONCLUSION The 10-year cumulative IBTR incidence in early breast cancer treated with external APBI using IMRT technique in 5 once-daily fractions is low and not different from that after WBI. Acute and late treatment-related toxicity and cosmesis outcomes were significantly in favor of APBI.
Phase I trial and pharmacokinetic study of two schedules of vincristine, oral irinotecan, and temozolomide (VOIT) for children with refractory solid tumors: A Children's Oncology Group Phase I Consortium study
Authors: Wagner L. M. , Perentesis J. P. , Reid J. M. , Ames M. M. , Safgren S. L. , Nelson M. D. , Ingle A. M. , Blaney S. M. , Adamson P. C. 
Published: August 2020

10017 Background: In preclinical models, temozolomide (TMZ) and vincristine (VCR) are synergistic with irinotecan (IRN). We sought to determine the dose limiting toxicities (DLTs) and maximum tolerated dose (MTD) of orally administered IRN given on two different schedules together with TMZ and VCR in children with refractory solid tumors, using cefixime to reduce IRN-associated diarrhea. Methods: Schedule A: Oral IRN daily for 5 days for 2 weeks (dx5x2), with VCR 1.5 mg/m2 on days 1 and 8 and TMZ 100 mg/m2 on days 1 - 5. Schedule B: Oral IRN daily for 5 days for 1 week (dx5x1) with VCR 1.5 mg/m2 on day 1 and TMZ 100 - 150 mg/m2 on days 1 - 5. Courses were repeated every 3 weeks. A standard cohorts of 3 + 3 design was used. Results: On Schedule A, 18 evaluable patients (median age 15 yrs, range 3 - 21) received 55 courses. At IRN 50 mg/m2/day, 4/12 pts had DLT (hepatotoxicity, abdominal pain, anorexia, hypokalemia, and thrombocytopenia). The oral IRN MTD on this dx5x2 schedule was 35 mg/m2/d (1/6 pts with DLT of hypoalbuminemia). On Schedule B, 18 evaluable patients (median age 9 yrs, range 3–21) received 71 courses of oral IRN 70 - 90 mg/m2/d x 5 with TMZ 100 - 150 mg/m2/d x 5. At oral IRN 90 mg/m2/d with TMZ 150 mg/m2/d, 0/6 pts had DLT, and no Grade 4 toxicities were seen. No further doses were explored. First-course and cumulative toxicity appeared worse with Schedule A, including 3 patients with responding or stable tumors who withdrew due to fatigue, nausea, and weight loss. UGT1A1*28genotype did not correlate with DLT. At the oral IRN MTD of 90 mg/m2/d, the median SN-38 AUCinf was 72 ng/ml*h. One patient with osteosarcoma had a confirmed partial response. Unconfirmed complete and partial responses were seen in 2 Ewing sarcoma patients. Eight additional patients received > 6 courses, including 2 each with neuroblastoma and medulloblastoma. Conclusions: The dx5x1 schedule of VOIT was well tolerated, with SN-38 exposures similar to those achieved with intravenous IRN. Activity on this and prior studies suggests a potential role for VOIT in sarcoma patients. No significant financial relationships to disclose.
Overall survival (OS) in contemporary randomized clinical trials (RCT) in advanced breast cancer (ABC)
Authors: Katz A. , Saad E. D. , Buyse M. E. 
Published: August 2020

1002 Background: OS has been considered an elusive endpoint, while progression-free survival (PFS), time to tumor progression (TTP), and time to treatment failure (TTF) have been used frequently and often interchangeably as primary endpoints (PE) in ABC (Saad, Ann Oncol 2009). Methods: We searched PubMed using the medical subject headings “breast neoplasms” and “drug therapy,” limiting the search to phase III trials on systemic antineoplastic therapies published between 1/2000 and 12/2007 in 8 leading medical journals (Ann Oncol, BCRT, BJC, Cancer, EJC, JCO, Lancet Oncol, and NEJM). PE was the one stated explicitly, used for N calculation, or listed first. Significant PE (SigPE) was considered as P <0.05 for superiority trials (N=47), or proven non-inferiority/equivalence otherwise. Results: We retrieved 58 RTCs, with a median sample size of 329 evaluable patients. The table shows the breakdown of these trials by size and PE, and the number of trials that reached statistical significance on their PE and on OS. Overall, a statistically significant gain in OS was reported in 11 of 58 RCTs (19%). In 30 RCTs with gain in PE, 26 favored the experimental arm. Conclusions: While publication and journal selection biases may not be excluded, our review suggests that gain in OS, although seldom a primary study objective, is not infrequent in contemporary RCTs in ABC. However, the majority of RCTs are underpowered for OS, which remains a secondary or exploratory endpoint in most cases. [Table: see text] No significant financial relationships to disclose.
Pegfilgrastim in pediatric sarcoma patients undergoing dose-intensive chemotherapy: Phase II study results
Authors: Spunt S. L. , Irving H. , Frost J. , Sender L. , Yang B. , Santana V. M. 
Published: August 2020

10024 Background: Children with cancer undergoing dose-intensive chemotherapy often require G-CSF support. Patients (pts) < 2 yrs have the highest risk of prolonged neutropenia due to imprecise dosing and immature drug clearance. Once-per-cycle pegfilgrastim may be beneficial due to neutrophil-mediated clearance that allows adequate serum levels throughout the neutropenic period. Young pts, who receive relatively more myeloablative chemotherapy, should have the highest pegfilgrastim exposure. Methods: Pts ≤21 yrs (age groups 0–5, 6–11, and ≥12 yrs) with sarcoma and scheduled to receive VAdriaC (cycles 1 & 3) and IE (cycles 2 & 4) were randomized 6:1 to receive pegfilgrastim 100 μg/kg or filgrastim (5 μg/kg/d until ANC ≥ 10×109/L) 24 hrs after chemotherapy administration. Post-nadir ANC recovery, incidence of ANC recovery by day 21 of cycles 1 & 3, pharmacokinetics (PK), and safety by age group were evaluated. Results: 43 pts (63% male) received pegfilgrastim (n=37) or filgrastim (n=6). Maximum pegfilgrastim concentration was achieved ∼24-hrs postdose and sustained until ANC nadir. Pegfilgrastim levels fell rapidly as ANC recovered. One child did not achieve ANC recovery by day 21 in cycle 1: an 8-mo-old 7.9-kg boy with non-metastatic undifferentiated sarcoma had 24 days of severe neutropenia in cycle 1. The youngest age group (including this child) had longer duration of severe neutropenia and, consequently, higher pegfilgrastim exposure ( Table ). Treatment-related adverse events were generally mild to moderate (pegfilgrastim 22%, filgrastim 33%); the only treatment-related event reported by >1 pt was bone pain (pegfilgrastim=11%, filgrastim=17%). Conclusions: ANC, PK, and safety profiles in pediatric patients were comparable with those in adults and support pegfilgrastim dosing across pediatric age groups. Consistent with neutrophil-mediated clearance, adequate exposure to pegfilgrastim was maintained in the youngest pts who received the most myelosuppressive chemotherapy. [Table: see text] [Table: see text]