bluuebunny/crossref_metadata_2025_split huggingface dataset:
High affinity between CREBBP/p300 and NCOA evolved in vertebrates
Authors: Karlsson Elin , Lindberg Amanda , Andersson Eva , Jemth Per 
Published: April 2020

AbstractThe interaction between the transcriptional coactivators CREBBP/p300 and NCOA is governed by two intrinsically disordered domains called NCBD and CID, respectively. The CID domain emerged within the NCOA protein in deuterostome animals (including vertebrates) after their split from the protostomes (molluscs, worms, and arthropods). However, it has not been clear at which point a high affinity interaction evolved within the deuterostome clade and whether all present‐day deuterostome animals have a high affinity NCBD:CID interaction. We have here expressed and measured affinity for NCBD and CID domains from animal species representing different evolutionary branches of the deuterostome tree. While all vertebrate species have high‐affinity NCBD:CID interactions we found that the interaction in the echinoderm purple sea urchin is of similar affinity as that of the proposed ancestral domains. Our findings demonstrate that the high‐affinity NCBD:CID interaction likely evolved in the vertebrate branch and question whether the interaction between CREBBP/p300 and NCOA is essential in nonvertebrate deuterostomes. The data provide an example of evolution of transcriptional regulation through protein‐domain based inventions.
The Integration of Photonic Crystal Waveguides with Atom Arrays in Optical Tweezers
Authors: Luan Xingsheng , Béguin Jean‐Baptiste , Burgers Alex P. , Qin Zhongzhong , Yu Su‐Peng , Kimble Harry J. 
Published: April 2020

AbstractIntegrating nanophotonics and cold atoms has drawn increasing interest in recent years due to diverse applications in quantum information science and the exploration of quantum many‐body physics. For example, dispersion‐engineered photonic crystal waveguides (PCWs) permit not only stable trapping and probing of ultracold neutral atoms via interactions with guided‐mode light, but also the possibility to explore the physics of strong, photon‐mediated interactions between atoms, as well as atom‐mediated interactions between photons. While diverse theoretical opportunities involving atoms and photons in 1D and 2D nanophotonic lattices have been analyzed, a grand challenge remains the experimental integration of PCWs with ultracold atoms. Here, an advanced apparatus that overcomes several significant barriers to current experimental progress is described, with the goal of achieving strong quantum interactions of light and matter by way of single‐atom tweezer arrays strongly coupled to photons in 1D and 2D PCWs. Principal technical advances relate to efficient free‐space coupling of light to and from guided modes of PCWs, silicate bonding of silicon chips within small glass vacuum cells, and deterministic, mechanical delivery of single‐atom tweezer arrays to the near fields of photonic crystal waveguides.
An Azo Dye Based D‐π‐A Chromogenic Probe for Selective Naked‐Eye Detection of Hg2+ Ion: Application in Logic Gate Operation
Authors: Tripathy Madhusmita , Subuddhi Usharani , Patel Sabita 
Published: April 2020

AbstractThe current work describes the selective colorimetric detection of metal ions using a simple azo dye (L1) containing donor‐π‐acceptor framework. In this chromogenic probe, salicylaldehyde is used as donor and nitrobenzene group as acceptor unit. L1 is found to show selective recognition of mercuric ion both visually and spectrophotometrically with no interference from environmentally relevant metal ions in DMSO‐water mixture. It exhibits reddish‐pink colour in DMSO‐water medium as a result of intramolecular charge transfer (ICT) from the electron donating phenolic group to electron withdrawing nitrobenzene group. It selectively binds with Hg2+ even in presence of other interfering metal ions and form a 1 : 1 L1‐Hg2+ adduct. It is evident from a change in colour along with a decrease of ICT absorption band and hypsochromic shift of π‐π* band. The binding of the chemosensor and mercuric ion through the salicylaldehyde unit is proved from 1H‐NMR data and DFT calculations. Using UV‐Vis spectroscopic technique the detection limit and binding constant values are calculated to be 6 μM and 3.3 x 103 M−1 respectively. Hg2+ probing process displays reversibility upon addition of fluoride ion. The on‐off‐on colorimetric change on sequential addition of Hg2+ and F− mimics an IMPLICATION type logic gate.
Palladium‐Supported Nanoceria: A Highly Efficient Catalyst for Solvent‐Free Selective Oxidation of Ethylbenzene to Acetophenone
Authors: Kalita Lisamoni , Saikia Lakshi 
Published: April 2020

AbstractThe benzylic C−H oxidation of ethylbenzene, a toxic petroleum waste, to high value‐added acetophenone is a fundamental yet important chemical transformation. Herein, palladium nanoparticles were immobilized on a highly mesoporous CeO2 surface for enhancing the catalytic activity. The Pd/CeO2nanocomposite was employed in the benzylic C−H oxidation of ethylbenzene under solvent‐free conditions and using tert‐butyl hydroperoxide as oxidant which displayed high conversion of 99.8% and a selectivity of 79% towards acetophenone. Moreover, the Pd/CeO2 catalysts were highly stable and could be recycled up to the fifth catalytic cycle without remarkable loss in its catalytic activity.
Near‐Infrared Fluorescence Hydrogen Peroxide Assay for Versatile Metabolite Biosensing in Whole Blood
Authors: Matoori Simon , Mooney David J. 
Published: April 2020

AbstractIn emergency medicine, blood lactate levels are commonly measured to assess the severity and response to treatment of hypoperfusion‐related diseases (e.g., sepsis, trauma, cardiac arrest). Clinical blood lactate testing is conducted with laboratory analyzers, leading to a delay of 3 h between triage and lactate result. Here, a fluorescence‐based blood lactate assay, which can be utilized for bedside testing, based on measuring the hydrogen peroxide generated by the enzymatic oxidation of lactate is described. To establish a hydrogen peroxide assay, near‐infrared cyanine derivatives are screened and sulfo‐cyanine 7 is identified as a new horseradish peroxidase (HRP) substrate, which loses its fluorescence in presence of HRP and hydrogen peroxide. As hydrogen peroxide is rapidly cleared by erythrocytic catalase and glutathione peroxidase, sulfo‐cyanine 7, HRP, and lactate oxidase are encapsulated in a liposomal reaction compartment. In lactate‐spiked bovine whole blood, the newly developed lactate assay exhibits a linear response in a clinically relevant range after 10 min. Substituting lactate oxidase with glucose and alcohol oxidase allows for blood glucose, ethanol, and methanol biosensing, respectively. This easy‐to‐use, rapid, and versatile assay may be useful for the quantification of a variety of enzymatically oxidizable metabolites, drugs, and toxic substances in blood and potentially other biological fluids.
Readiness model for requirements change management in global software development
Authors: Akbar Muhammad Azeem , Mahmood Sajjad , Huang Zhiqiu , Khan Arif Ali , Shameem Mohammad 
Published: April 2020

AbstractRequirements Change Management (RCM) is one of the challenges faced by Global Software Development (GSD) organisations as requirements evolution is inevitable due to dynamic business and operating environments. GSD organisations face issues when dealing with RCM because many organisations embark on GSD without understanding their readiness to undertake such an initiative. Currently, there is no readiness model to assess the RCM process in the context of GSD. The objective of this study is to develop a requirements change management readiness model (RCMRM) for GSD organisations. A Systematic Mapping Study (SMS) was conducted to identify the primary studies related to RCM in the GSD projects. By using SMS, 109 primary studies were selected and 73 RCM practices were identified which were used to design the readiness levels of the proposed RCMRM. To validate the RCMRM, initially, two case studies were conducted in two GSD organisations. Based on the suggestions and recommendations of the case study participants,the RCMRM was further modified. The updated version of RCMRM was further validated by two different GSD organisations. The results of the second case study indicate that RCMRM is effective in assessing the readiness of the RCM process in the context of GSD.
A review on the computation offloading approaches in mobile edge computing: A game‐theoreticperspective
Authors: Shakarami Ali , Shahidinejad Ali , Ghobaei‐Arani Mostafa 
Published: April 2020

SummaryIn recent years, novel mobile applications such as augmented reality, virtual reality, and three‐dimensional gaming, running on handy mobile devices have been pervasively popular. With rapid developments of such mobile applications, decentralized mobile edge computing (MEC) as an emerging distributed computing paradigm is developed for serving them near the smart devices, usually in one hop, to meet their computation, and delay requirements. In the literature, offloading mechanisms are designed to execute such mobile applications in the MEC environments through transferring resource‐intensive tasks to the MEC servers. On the other hand, due to the resource limitations, resource heterogeneity, dynamic nature, and unpredictable behavior of MEC environments, it is necessary to consider the computation offloading issues as the challenging problem in the MEC environment. However, to the best of our knowledge, despite its importance, there is not any systematic, comprehensive, and detailed survey in game theory (GT)‐based computation offloading mechanisms in the MEC environment. In this article, we provide a systematic literature review on the GT‐based computation offloading approaches in the MEC environment in the form of a classical taxonomy to recognize the state‐of‐the‐art mechanisms on this important topic and to provide open issues as well. The proposed taxonomy is classified into four main fields: classical game mechanisms, auction theory, evolutionary game mechanisms, and hybrid‐base game mechanisms. Next, these classes are compared with each other according to the important factors such as performance metrics, case studies, utilized techniques, and evaluation tools, and their advantages and disadvantages are discussed, as well. Finally, open issues and future uncovered or weakly covered research challenges are discussed and the survey is concluded.
Understanding and improving the usefulness of conceptual systems: An Integrative Propositional Analysis‐based perspective on levels of structure and emergence
Authors: Wallis Steven E. 
Published: April 2020

AbstractTerms like ‘levels’ and ‘nested’ are used to describe relationships between components of conceptual systems (theories, models etc.). However, they have not been fully explored. This paper investigates levels to better understand how theories are structured and so how we may develop more useful theories and models to better support more effective practice. We find a horizontal dimension (represented by causal connections between concepts at one ontological level) and a vertical dimension (represented by connections of emergence between concepts of differing ontological levels). This view of emergence offers a new way to structurally distinguish between conceptual components of a theory, thus supporting a new approach to building theories that better reflects our systemic world. A third, perspectival, approach may be applied to aid in the understanding of both dimensions. A typology is proposed as are conventions for diagramming theories and new criteria for improving the structure of theories.
Influence of organic UV absorber on the accelerated weathering stability of UV curing coating based on acrylate urethane resin
Authors: Vuong Nguyen Thien , Nguyet Ha Minh , Linh Dang Thi My 
Published: April 2020

AbstractThe purpose of this paper is to evaluate the photoprotective efficiency of organic UV absorber Tinuvin 384 (T384) on the photocurable acrylate urethane coating under the accelerated weathering condition. The coatings without and with 2 wt.% T384 were examined by UV/CON accelerated weathering testing device. The aging of the coatings was assessed by IR and FE‐SEM analysis as well as the measurement of mechanical and weight loss. The obtained results showed that due to the photoprotection of T384, the urethane acrylate coating was stable under the effect of accelerated weathering factors. After 48 cycles of aging, the CH and CNH groups, the abrasion resistance and the weight of the paint films containing 2 wt.% T384 were slightly decreased. Its surface was damaged just a little, while that of the coating without T384 was severely degraded.
Synthesis and computational mechanistic studies of copper selective molecular receptor
Authors: Mohan Brij , Modi Krunal , Patel Chirag , Kumar Sandeep , Sharma Harish Kumar 
Published: April 2020

AbstractAlthough numerous molecular receptors for Cu2+ have been reported, it is not obvious to find a simple molecule as a selective receptor for Cu2+. Here we create a molecular receptor 4MHEB for Cu2+ metal ions. Observation of a new absorption band near 282 nm in UV‐visible spectra and enhancement in fluorescence intensity in emission spectra justify the binding 4MHEB:Cu2+ binding. Inspection in shifting of IR bands, different thermal behavior and oxidation and reduction peaks of complex shows binding of 4MHEB:Cu2+. HRMS m/z 322.0328, Benesi‐Hildebrand method and Job's Plot results 1:1 (4MHEB:Cu2+) binding stoichiometry with the binding affinity K = 1.751×105 M‐1. The docked pose of 4MHEB with Cu2+ ion, Key transitions, % Contribution was calculated by computational studies.
Correlation between IRC7 gene expression and 4‐mercapto‐4‐methylpentan‐2‐one production in Saccharomyces cerevisiae strains
Authors: Tofalo Rosanna , Perpetuini Giorgia , Battistelli Noemi , Tittarelli Fabrizia , Suzzi Giovanna 
Published: April 2020

AbstractVolatile thiols are not present in must but are synthesized and released by wine yeasts during alcoholic fermentation. In this study, autochthonous and commercial Saccharomyces cerevisiae strains were characterized for the expression of the main genes involved in thiols metabolism and their production in wine. New primer sets were developed on the basis of the S288c genome to evaluate the expression of Cys3, Cys4, MET17 and IRC7 genes. Obtained data revealed the occurrence of some thiols, for example, 4‐mercapto‐4‐methylpentan‐2‐one (4‐MMP) and 3‐mercaptohexan‐1‐ol (3‐MH) in Pecorino white wine. All genes were upregulated, but only for IRC7 was found a correlation with 4‐MMP release: strains with the highest production showed the highest transcription level. IRC7 gene could be proposed as target for the selection of S. cerevisiae strains to increase thiols content in wine.
All-suture anchor pullout results in decreased bone damage and depends on cortical thickness
Authors: Ntalos Dimitris , Huber G. , Sellenschloh K. , Saito H. , Püschel K. , Morlock M. M. , Frosch K. H. , Klatte T. O. 
Published: April 2020

Abstract
Purpose
To evaluate the influence of cortical and cancellous bone structure on the biomechanical properties of all-suture and conventional anchors and compare the morphological bone damage after their failure. The hypothesis of the study is that all-suture anchor pullout is less invasive and that the pullout force is influenced by the cortical thickness.

Methods
Thirty human humeri were biomechanically tested as follows: starting with a load cycle from 20 to 50 N, a stepwise increase of the upper peak force by 0.05 N for each cycle at a rate of 1 Hz was performed. Analysis included maximum pullout strength for three different anchor implantation angles (45°, 90°, 110°) of the two anchor types. After anchor pullout, every sample underwent micro-CT analysis. Bone mineral density (BMD) and cortical thickness were determined at the anchor implantation site. Furthermore, the diameter of the cortical defect and the volume of the bone cavity were identified.

Results
The maximum pullout strength of all-suture anchors demonstrates a strong correlation to the adjacent cortical thickness (r = 0.82, p ≤ 0.05) with at least 0.4 mm needed to withstand 200 N. No correlation could be seen in conventional anchors. Moreover, no correlation could be detected for local BMD in both anchors. All-suture anchors show a significantly narrower cortical defect as well as a smaller bone cavity following pullout (4.3 ± 1.3 mm vs. 5.3 ± 0.9 mm, p = 0.037; 141 mm3 vs. 212 mm3; p = 0.009). The cortical defect is largest if the anchors are placed at a 45° angle.

Conclusion
In contrast to conventional anchors, the pullout force of all-suture anchors depends on the thickness of the humeral cortex. Furthermore, all-suture anchors show a significantly smaller cortical defect as well as decreased bone damage in the case of pullout. Therefore, the clinical implication of this study is that all-suture anchors are advantageous due to their bone preserving ability. Also, intraoperative decortication should not be performed and cortical thickness should be preoperatively evaluated to decrease the risk of anchor failure.
A phase II study of ibrutinib in combination with rituximab-cyclophosphamide-doxorubicin hydrochloride-vincristine sulfate-prednisone therapy in Epstein-Barr virus-positive, diffuse large B cell lymphoma (54179060LYM2003: IVORY study): results of the final analysis
Authors: Yoon Sang Eun , Kim Seok Jin , Yoon Dok Hyun , Koh Youngil , Mun Yeung-Chul , Do Young Rok , Choi Yoon Seok , Yang Deok Hwan , Kim Min Kyoung , Lee Gyeong-Won , Suh Cheolwon , Ko Young Hyeh , Kim Won Seog 
Published: April 2020

AbstractEpstein-Barr virus (EBV) positivity in diffuse large B cell lymphoma (DLBCL) provokes a critical oncogenic mechanism to activate intracellular signaling by LMP1. LMP1 specifically mimics the role of BTK-dependent B cell receptor. Therefore, a trial considering RCHOP therapy along with ibrutinib (I-RCHOP) in combination was conducted among patients with EBV-positive DLBCL. This study was an open-label, single-arm, prospective multicenter phase II clinical trial. Patients received 560 mg of ibrutinib with RCHOP every 3 weeks until 6 cycles were completed or progression or unacceptable toxicity was observed. The primary endpoint was objective response, while secondary endpoints included toxicity, progression-free survival, and overall survival. A matched case-control analysis was completed to compare the efficacy and toxicity of I-RCHOP and RCHOP, respectively, in EBV-positive DLBCL patients. From September 2016 to August 2019, 24 patients proven to have EBV-positive DLBCL in the tissue were enrolled and received I-RCHOP. Their median age was 58 years (range, 28–84 years). The objective overall response was 66.7%, including 16 patients who achieved complete response after 6 cycles. Patients aged younger than 65 years presented a superior OR (87.5%) as compared with those older than 65 years (25.0%; p = 0.01). In a matched case-control study, I-RCHOP therapy provoked a more favorable complete response rate (87.3%) than did RCHOP (68.8%) in those younger than 65 years. Treatment-related mortality was linked most frequently with I-RCHOP therapy (four patients presented with unusual infection without Gr3/4 neutropenia) in the older age group (age ≥ 65 years). In conclusion, in this phase II trial for EBV-positive DLBCL, I-RCHOP was effective but did not show a significant improvement in response and survival in comparison with RCHOP. Also, I-RCHOP promoted serious toxicity and treatment-related death in older patients.
Local and regional environmental factors drive the spatial distribution of phototrophic biofilm assemblages in Mediterranean streams
Authors: Witteveen Nina H. , Freixa Anna , Sabater Sergi 
Published: April 2020

AbstractTemporary streams are submitted to high seasonal hydrological variations which induce habitat fragmentation. Global change promotes longer non-flow periods, affecting hydrological continuity and the distribution of biological assemblages in river networks. We aimed to investigate the effects of hydrological discontinuity on phototrophic biofilm assemblages in a Mediterranean stream, at both network and habitat scales. At the network scale during basal flow conditions, mostly nitrate and DOC concentrations were associated to the taxonomical and trait distribution of algae and cyanobacterial assemblages. Cyanobacteria dominated at the upstream and downstream sites of the network, while green algae and diatoms were abundant in its middle part. At the habitat scale, hydrological discontinuity promoted large changes in biofilm composition between riffles and pools, where pools were inhabited preferentially by green algae and riffle habitats by cyanobacteria. Our findings emphasize the myriad of factors affecting the spatial distribution of phototrophic biofilms, which become more heterogeneous according to water flow interruption. Under the predicted climate change scenarios, spatial heterogeneity in temporary streams may increase, which will lead to change phototrophic biofilm assemblages.
Stability and attrition in American Norwegian nominals: a view from predicate nouns
Authors: Kinn Kari 
Published: April 2020

AbstractThis study investigates the extent to which speakers of American Norwegian (AmNo), a heritage language spoken in the United States and Canada, use the indefinite article in classifying predicate constructions (‘He is (a) doctor’). Despite intense contact with English, which uses the indefinite article, most AmNo speakers have retained bare nouns, i.e., the pattern of Norwegian as spoken in Norway. However, a minority of the speakers use the indefinite article to some extent. I argue that generally, this use of the indefinite article has arisen through attrition (i.e., a change during the lifetime of individuals), not through divergent attainment causing systematic, parametric change in the Norwegian grammar of these speakers. I also argue that representational economy is one of the factors that may have contributed to the relative stability of bare nouns.
Typicality and Minutis Rectis Laws: From Physics to Sociology
Authors: Wagner Gerhard 
Published: April 2020

AbstractThis paper contributes to the clarification of the concept of “typicality” discussed in contemporary philosophy of physics by conceiving the nomological status of a typical behaviour such as that expressed in the Second Law of Thermodynamics as a “minutis rectis law”. A brief sketch of the discovery of “typicality” shows that there were ideas of typical behaviour not only in physics but also in sociology. On this basis and in analogy to the Second Law of Thermodynamics, it is shown that the nomological status of sociological laws such as Gresham’s Law can also be conceived as “minutis rectis laws”.