bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parvimonas Micra Promotes Intestinal Tumorigenesis in Conventional Apcmin/+ Mice and in Germ-Free Mice
Authors: Zhao Liuyang , Zhou Yunfei , Zhao Risheng , Coker Olabisi Oluwabukola Oluwabukola , ZHANG Xiang , Chu Eagle SH , Wei Hong , Wu William KK , Wong Sunny Hei , Sung Joseph JY , To Ka Fai , Yu Jun 
Published: May 2020

Abstract
Background:Large-scale meta-analysis of fecal shotgun metagenomic sequences revealed high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role of P. micra in colon tumorigenesis.Results: P. micra was significantly enriched in 128 stool samplesfrom CRC patients compared with 181 samples from healthy controls(p<0.0001) and in 52 pairedtissue biopsies from CRC patientsthan 61 samples from healthy individuals (p<0.05). P. micra strain 512 was isolated from the feces of a CRC patient.Colon cell lines exposed to P. micra- conditioned medium significantly increased cell proliferation.Apcmin/+ mice gavaged with P. micra exhibited significantly higher tumor burden and load (both p<0.01). Consistently, cell proliferation was significantly higher in the colon tissues of germ-free mice gavaged with P. micraevidenced by increased Ki-67-positive cells and PCNA protein expression. Th2 and Th17 cells were markedly increased, while Th1 cells were reduced in the lamina propria of the colon tissues of mice gavaged with P. micra (all p<0.01). Moreover, P. micra colonization in germ-free mice was associated with increased expression of pro-inflammatory cytokines including Tnf-α, Il17a, Il6 and Cxcr1.Conclusions: P. micra promoted intestinal carcinogenesis in Apcmin/+ mice and increased cell proliferation in germ-free mice. The tumor-promoting effect of P. micra was associated with altered immune responses and enhanced inflammation in the gut.
Estimation of fuel potential of faecal sludge in a water scarce city, a case study of Jaipur Urban, India
Authors: Sharma Niharika , Gupta Sagar , Vyas Anil Dutt 
Published: May 2020

Abstract
Non-sewer sanitation systems are widely implemented for treatment and management of faecal sludge (FS) and septage in developing nations. India became an open defecation free (ODF) country in 2019, with more than 90 million toilets at rural and urban level constructed to achieve this ODF status. Government of India also initiated a faecal sludge and septage management (FSSM) policy in 2017. This paper highlights the policy vision for the state of Rajasthan and predicts options for a safely managed sanitation system through exploring the fuel potential of faecal sludge generated in the city. The intended study is an attempt to valorize faecal sludge into a marketable product through determining the heat capacity of dried faecal sludge from different sources such as pit toilets, septic tanks etc. In the present work in urban Jaipur, which is already a water scarce city, various onsite sanitation systems were targeted to collect FS samples from different locations. It was observed that the FS generated has a high heating value of 13.96 MJ/kg, with total solids ranges from 7 to 9%. For a pragmatic resource recovery option, the experimental data observed is validated with a literature review.
Effect of Nectaroscordum koelzi Methanolic Extract on Acute and Chronic Inflammation in Male Mice
Authors: Khaksarian Mojtaba , Mahmoudvand Hormoz , Alipour Maryam , Naizi Massumeh , Hasanvand Karam Hossein , Nadri Sedighe 
Published: May 2020

Introduction:
The present study deals with the effect of Nectaroscordum koelzi fruit
extract on acute and chronic inflammation.

Methods:
A total of 84 NMRI mice were used in this study. The effect of the extract on acute inflammation
was analyzed by increasing vascular permeability via acetic acid and xylene induced
ear edema among mice. The extract was evaluated in terms of effects on chronic inflammation by
means of the cotton pellet test among mice. For the assessment of inflammation degree, the mice
paw edema volume was measured by the plethysmometric test.

Results:
The findings showed that the extract was effective on acute inflammation induced by
acetic acid in mice. In the xylene ear edema, N. koelzi extract indicated a significant activity in
mice. In the cotton pellet method, the methanol extract produced a significant reduction in comparison
with the control and dexamethasone. Mice paw edema volume decreased with the extract.

Conclusion:
In general, the data from the experiments indicated that the methanol extract of N.
koelzi has an anti-inflammatory effect on acute and chronic inflammation. However, the exact
contributing mechanisms have not been investigated for the pharmacological effects.
The Intersection of Maternal Morbidity and Mortality and Intimate Partner Violence in the United States
Authors: Noursi Samia , Clayton Janine Austin , Campbell Jacquelyn , Sharps Phyllis 
Published: May 2020

Background:
In the United States, rates of maternal morbidity and mortality (MMM) are
high compared with other high-income countries and are characterized by significant racial/ethnic
disparities. Typically, research on MMM focuses on obstetrical problems. Less research examines
the role of intimate partner violence (IPV). Maternal health, IPV, and their intersection are linked
with the impacts of social determinants of health.

Objective:
We sought to understand the intersection of MMM and IPV in the United States, particularly
data issues that hinder research in this area and the resulting knowledge gaps.

Methods:
We identified major articles of interest regarding maternal morbidity and mortality and
IPV in the United States and drafted a mini review based on relevant information.

Results:
Despite the prevalence of IPV during pregnancy, the intersection of maternal health and
IPV has not been widely reviewed or discussed.

Conclusion:
There are a number of limitations in surveillance activities and data collection that
underestimate the impact of IPV on MMM. Importantly, women who die by homicide or suicide—
which in many cases is linked with IPV—are not counted as pregnancy-related deaths in the United
States under the current definition. Establishing separate panels of local experts in maternal health
or maternal mortality review committees (MMRCs) that are dedicated to examining violent deaths
and use of the Maternal Mortality Review Information Application system would likely improve
data accuracy of pregnancy-associated deaths. Based on the literature reviewed and limitations of
current data, there are significant knowledge gaps on the effects of IPV and maternal health.
The Apoptosis Mechanism of Epirubicin Combined with BCG on Human Bladder Cancer Cells
Authors: Luo Yang , Fu Xiaoyi , Han Bin , Zhang Fafu , Yuan Lihong , Men Hongsheng , Zhang Shulin , Tian Sujuan , Dong Bin , Meng Minjie 
Published: May 2020

Aims:
The purpose of our study was to explore the combination effect of epirubicin and Bacillus
Calmette Guerin (BCG) and its mechanism.

Background:
Bladder cancer is a threat to human health worldwide. Commonly used chemotherapy drugs and
biotherapy have significant therapeutic effects on bladder cancer, but the mechanism and combined effects are
still unclear.

Objective:
To evaluate the anti-cancer effect of epirubicin combined with BCG on human bladder cancer cells,
our studies were carried out.

Methods:
The viability of human bladder cancer cells with epirubicin and/or BCG treatments was
examined by Cell Counting Kit-8 (CCK-8) assay. Apoptosis and cell cycle phase were
determined by flow cytometry analysis. Pre-apoptosis factors of caspase-3, p53, B-cell
lymphoma 2 associated X protein (Bax) and anti-apoptosis factor of B-cell lymphoma 2 (Bcl2) were detected by western blot.

Results:
The viability of human bladder cancer with epirubicin or BCG treatment was decreased and the viability
with epirubicin combined with BCG treatment was decreased more, which were determined by CCK-8
assay. Both epirubicin and BCG increased the apoptosis rate of human bladder cancer and arrested more cells
into G0/G1 phase, which were tested by flow cytometry. The expression of caspase-3, p53 and Bax was increased
and the expression of Bcl-2 was decreased with epirubicin treatment on human bladder cells, which
were analyzed by western blot. The expression of caspase-3 and p53 was increased with BCG treatment, which
was examined by western blot.

Conclusion:
Epirubicin induced apoptosis in human bladder cancer cells by up-regulating the expression of proapoptotic
factors (caspase-3, p53 and Bax) and down-regulating the expression of anti-apoptotic factor (Bcl-2).
BCG promoted apoptosis of human bladder cancer cells by up-regulating the expression of caspase-3 and p53.
BCG plays a potential role at the time of the combination of epirubicin and BCG on bladder cancer cells in early
stage. Both epirubicin and BCG affected cell cycle distribution via arresting more bladder cancer cells at G0/G1
phase, which ultimately led bladder cancer proliferation in vitro and promoted apoptosis.
MicroRNA-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells
Authors: Ragheb Mohamed A. , Soliman Marwa H. , Elzayat Emad M. , Mohamed Mervat S. , El-Ekiaby Nada , Abdelaziz Ahmed I. , Abdel-Wahab Abdel-Hady A. 
Published: May 2020

Background:
Doxorubicin (DOX) is the most common drugs used in cancer therapy, including
Hepatocellular Carcinoma (HCC). Drug resistance, is one of chemotherapy’s significant
problems. Emerging studies have shown that microRNAs (miRNAs) could participate in
regulating this mechanism. Nevertheless, the impact of miRNAs on HCC chemoresistance is still
enigmatic.

Objective:
Investigating the role of miR-520c-3p in enhancement of anti-tumor effect of DOX
against HepG2 cells.

Methods:
Expression profile for liver related miRNAs (384 miRNAs) has been analyzed on
HepG2 cells treated with DOX using qRT-PCR. miR-520c-3p, the most deregulated miRNA,
was selected for combination treatment with DOX. Expression level for LEF1, CDK2, CDH1,
VIM, Mcl-1 and TP53 was evaluated in miR-520c-3p transfected cells. Cell viability, colony
formation, wound healing as well as apoptosis assays have been demonstrated. Furthermore,
Mcl-1 protein level was measured using western blot technique.

Results:
The present data indicated that miR-520c-3p overexpression could render HepG2 cells
chemo-sensitive to DOX through enhancing its suppressive effects on proliferation, migration,
and induction of apoptosis. The suppressive effect of miR-520c-3p involved altering the
expression levels of some key regulators of cell cycle, proliferation, migration and apoptosis
including LEF1, CDK2, CDH1, VIM, Mcl-1 and TP53. Interestingly, Mcl-1 was found to be one
of the potential targets of miR-520c-3p, and its protein expression level was down-regulated
upon miR-520c-3p overexpression.

Conclusion:
Our data referred to the tumor suppressor function of miR-520c-3p that could
modulate chemosensitivity of HepG2 cells toward DOX treatment, providing a promising
therapeutic strategy in HCC.
The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information
Authors: Dereli Fatma T.G. , Ilhan Mert , Akkol Esra K. 
Published: May 2020

Background:
The fruits with the seeds of Dracunculus vulgaris Schott. (Araceae) are used against
inflammatory diseases in Turkey.

Objective:
Present study was designed to justify this folkloric usage type of the plant. Therefore, the aim of this study
is to investigate the anti-inflammatory activity of D. vulgaris.

Methods:
Petroleum ether, ethyl acetate and methanol extracts were prepared from the fruits, successively.
Carrageenan-, serotonin-, and prostaglandin E2-induced hind paw edema; acetic acid–induced capillary permeability
and 12-O-tetradecanoyl-phorbol-13-acetate–induced mouse ear edema models were used to assess the antiinflammatory activity of the extracts. The analgesic activity was experienced by using p-benzoquinone-induced
abdominal constriction test.

Results:
The petroleum ether extract displayed the highest activities in all of the used test models compared with the
control group. Therefore, the constituents of this extract were determined by using gas chromatography–mass
spectroscopy (GC–MS). Linoleic acid was found to be major constituent of the petroleum ether extract of D.
vulgaris.

Conclusion:
This study has provided some justification for the folkloric use of the plant.
Design of Quantum Cost and Delay Optimized Code Converter Using New Reversible Quantum Circuit Block (QCB)
Authors: Maity Heranmoy , Banerjee Sudipta , Mistry Raton , Kundu Parna , Ojha Kriti , Manwani Priya , Sen Barnali , Verma Ishika , Biswas Arindam , Pal Anita , Bhattacharjee Anup Kumar 
Published: May 2020

Background:
In this article, we have proposed a new reversible quantum circuit block along
with the quantum cost (QC), constant input (CI), garbage output (GO) and delay optimized
code converterusing quantum circuit block.

Method:
Initially, new quantum circuit block has been designed and later reversible code
converter circuits have been implemented using it. The proposed new quantum blockused
to design 2’s complement code converter (2SCCC), cost efficient BCD to Excess-3 code
converter (BECC) and can also be used to implement different logic functions. The QC of
proposed quantum circuit block is 8. The QC and delay of the proposed 2SCCC is 8 and 1
respectively. Similarly, the QC and delay of the proposed BECC is 11 and 2 respectively.
The proposed cost efficient BECC is designed using two NOT gate, one Feynman gate and
one new quantum circuit block with QC is 11.

Results:
The improvement of QC for 2SCCC and BECC are 27.27 % and 21.43%
respectively. The improvement of delay for 2SCCC and BECC are 66.67% and 50%
respectively compared with respect to the latest reported results.

Conclusion:
So the improvement of QC and delay are very high using QCB.
A problemática da violência Conjugal em Moçambique
Authors: Leao Cezerilo Fernanda Amelia dos Santos 
Published: May 2020

Com o presente artigo pretende-se fazer um estudo sociológico sobre a violência conjugal entre casais heteronormativo, fenômeno presente em muitos relacionamentos afectivos. Para a operaconalização deste trabalho recorreu se a pesquisa biblográfica, análise documental e entrevistas informais com alguns atores sociais que dia a dia lidam e intervêm nestes casos, para melhor perceber como é que se dá esta violência conjugal, com o fito de sugerir medidas para a sua prevenção, devido as suas nefastas consequências, em especial para a saúde dos envolvidos. A violência representa ou constitui uma grande inquietação para a sociedade O estudo visa igualmente proporcionar uma reflexão a partir de dados teóricos sobre o gênero e desigualdades resultantes do sistema patriarcal, que pode estar relacionado com a prática da violência em relacionamentos conjugais e ao mesmo tempo visa servir de um alerta para a sociedade em geral sobre esta problematica social. Os resultados apontam que a violência do gênero em Moçambique independe do nível de escolaridade da vítima.
Palavras-chave: Gênero.Violência. Resiliência. Relação conjugal.
A desigual distribuição do status de criminoso:
Authors: Kobielski Marina Balestrin , Azevedo Rodrigo Ghiringhelli 
Published: May 2020

A percepção das dinâmicas de criminalização e estigmatização, pensadas desde a teoria do Labeling Approach, passando pelo estudo dos crimes de colarinho branco, até conceitos propostos na contemporaneidade são o fio condutor deste trabalho. A partir disso, abordar a criminalidade patrimonial, tomando como objeto de estudo os tipos penais de furto e peculato, com o fim de verificar a existência de diferenciação no tratamento dos sujeitos que praticam tais delitos pelo sistema de justiça criminal é o objetivo principal deste artigo.
Movimentos sociais e direito
Authors: Bonfigli Fiammetta , Schwartz Germano 
Published: May 2020

O presente artigo visa a recompor e a interpretar os acontecimentos que fizeram do Brasil um teatro de protestos em massa contra o aumento da tarifa dos ônibus urbanos no ano de 2013 Movimento Passe Livre. O ensaio tem como foco especifico a cidade de Porto Alegre e a ocupação de sua Câmara de Vereadores em julho 2013. O objetivo é o de entender a relação entre a organização política do Bloco de Luta pelo Transporte Publico e seu GT Jurídico durante os oito dias de ocupação. Por meio de nove entrevistas semiestruturadas realizadas exclusivamente com os componentes do GT mencionado, procura-se entender como o Direito é uma ferramenta utilizada pelos movimentos sociais, quais suas dinâmicas relacionais e quais são seus pontos convergentes e divergentes. Nesse sentido, especial atenção é dada ao deferimento da reintegração de posse e a elaboração de dois projetos de lei sobre o transporte público como principais momentos de relação entre a organização coletiva da ocupação e o GT jurídico.
Cостояние тиреоидной функции у пациентов с сахарным диабетом 1-го типа и хронической болезнью почек, получающих почечно-заместительную терапию
Authors: Sazonоva A.G. , Mokhort T.V. , Karlovich N.V. , Snapkov V.S. , Valovik O.E. , Ilinchik O.V. 
Published: May 2020

Актуальность. Нарушения функции щитовидной железы (ЩЖ) являются распространенной эндокринной патологией среди пациентов с хронической болезнью почек (ХБП), в том числе получающих почечно-заместительную терапию (ПЗТ). Результаты the Third National Health and Nutrition Examination Survey продемонстрировали, что доля пациентов с гипотиреозом возрастает до 23 % при прогрессирующем нарушении функции почек. Цель исследования: изучить влияние ПЗТ на тиреоидную функцию пациентов с сахарным диабетом (СД) 1-го типа и ХБП. Материалы и методы. С целью оценки тиреоидного статуса у пациентов с терминальной ХБП в одномоментное исследование были включены 155 пациентов с СД 1-го типа. В оценке функционального статуса ЩЖ использовались расчетные показатели: индекс периферической конверсии и интегральный тиреоидный индекс (ИТИ). ИПК рассчитывался как отношение свободного Т4 к свободному Т3. Результаты. Не было обнаружено достоверных различий между группами пациентов, получающих ПЗТ, и больных СД 1-го типа с коморбидной ХБП и без нее по уровням общих Т4 и Т3, тиреоглобулина, антител к тиреоглобулину и тиреоидной пероксидазе. Отмечены достоверно более низкие показатели свободного Т4 и свободного Т3 с максимальным снижением при получении ПЗТ. Достоверное снижение уровней антител к рецепторам ТТГ в группе пациентов на ПЗТ в целом, а также после проведения процедуры гемодиализа подтверждает отсутствие влияния аутоиммунного компонента на генез тиреоидных нарушений у пациентов с ХБП и ПЗТ. Определено отсутствие связи между показателями тиреоидного статуса и уровнем компенсации СД 1-го типа у пациентов на ПЗТ, а также между длительностью ХБП и сроками проведения ПЗТ и показателями тиреоидного профиля у пациентов с СД 1-го типа. Выводы. Выявленные изменения предопределяют необходимость оценки уровней сывороточных свободных фракций периферических гормонов ЩЖ, а также проведение гормонального исследования непосредственно после процедуры гемодиализа.
Синдром тиреотоксикоза: новые клинические возможности коррекции тиреоидной дисфункции
Authors: Pankiv V.I. 
Published: May 2020

Статья посвящена анализу литературы по изучению спектра терапевтических свойств препарата лапчатки белой, дополненного селеном и цинком, назначающегося в дополнение к стандартному ведению пациентов с гиперфункцией щитовидной железы. В виде монотерапии — при субклиническом тиреотоксикозе первой степени, а также при достижении стойкой компенсации диффузного токсического зоба. В составе комплексной терапии — при субклиническом тиреотоксикозе второй степени, диффузном токсическом зобе при нормализации содержания Т4 и Т3 в крови.
Гликированный гемоглобин: механизмы образования и клиническое значение (обзор литературы и собственные исследования)
Authors: Radchenko O.M. , Korolyuk O.Ya. 
Published: May 2020

Уровень гликированного гемоглобина (HbA1c) свидетельствует о содержании в организме конечных продуктов усиленного гликозилирования (advanced glycation end products, AGE), однако на практике необходимость в его определении недооценивается. С целью обсуждения диагностического и прогностического значения HbA1c проведен обзор литературы, проанализованы результаты обследования 116 больных ишемической болезнью серца с детальным анализом метаболизма углеводов, включая проспективное наблюдение за ними на протяжении 40 месяцев. Установлено, что уровень HbA1c свидетельствует о содержании AGE, которые стимулируют продукцию свободных радикалов и окислительную модификацию белков и липидов, уменьшают клеточный транспорт, активируют воспалительные цитокины и хемокины, вызывают иммунные реакции и мутации, повышают активность молекул адгезии и нарушают функцию рецепторов. Обсуждается их роль в патогенезе многих заболеваний — артериальной гипертензии, диабетических сосудистых осложнений, нефропатии, атеросклероза, болезни Альцгеймера, деменции, катаракты, преждевременного старения, потери мышечной массы, плохого заживления ран и злокачественных опухолей и др. По собственным данным, HbA1c является маркером неудовлетворительного метаболического контроля в течение последних трех месяцев, сосудистых осложнений сахарного диабета, коронарной патологии, дислипидемий, инсулинорезистентности, системного воспаления и высокой вероятности возникновения сахарного диабета в ближайшие три года. Этот показатель позволяет дифференцировать острую стрессовою и хроническую гипергликемии. Содержание HbA1c следует контролировать не только у больных сахарным диабетом, но и у лиц пожилого и старческого возраста, курящих, пациентов с атеросклеротическим поражением сосудов и хеликобактерной инфекцией.
Erasmus Syllogisms in Cognition and Facilitation of Organizational Innovation
Authors: Bye Rolf Johan , Johansen Stein Erik 
Published: May 2020

By use of an empirical example from a planned organizational change program within an international company, we examine how specific characteristics of objects (forms) used to represent ideas – in interaction with “hard-wired” aspects of human cognition – may contribute to explain outcomes of translation processes and the extent of alteration of the design of the future organization. We argue that a type of syllogism judged as invalid by criteria of formal logics – denoted as Erasmus syllogism – could be rather common in reasoning, and that these logically invalid interferences may contribute to significant innovations. Situations where syllogisms are not recognized as invalid by the involved actors seem to be more prevalent when e.g. the actors are unfamiliar with the semantic content (as e.g. abstract symbols). We argue that understanding of semiotic conditions for occurrence of formal logically invalid syllogism, as well as of the neglect of their invalidity by involved actors in ongoing discourses and reasoning, may contribute to a better understanding of how ideas and objects are translated, within organizations as well as in general. The discussion is a contribution to better understanding of why and how ideas are altered as part of ongoing sense making processes within organizations.