bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and timing of gastrografin administration after ileus tube insertion in patients with adhesive small bowel obstruction
Authors: Tamura Yu , Esaki Mitsuru , Ichijima Ryoji , Suzuki Sho , Iwamoto Maho , Moriyama Mitsuhiko , Gotoda Takuji 
Published: February 2020

Abstract
Background: Gastrointestinal decompression through ileus tube is useful for the treatment of adhesive small bowel obstruction (ASBO). Gastrografin administration through the ileus tube is performed if decompression therapy fails to relieve obstruction. However, the efficacy and appropriate timing of gastrografin administration are unclear. This study aimed to evaluate the efficacy of gastrografin administration within 48 h after admission.
Methods: This retrospective study used the data of patients with ASBO admitted to our hospital between January 2014 and August 2018 and included those who underwent ileus tube intubation but did not achieve obstruction relief for over 24 h after admission. The patients were classified into the following two groups: those treated with gastrografin administration within 48 h after admission (EGA group) and those treated without gastrografin administration within 48 h after admission (non-EGA [NEGA] group). Propensity-score matching was performed to compensate for confounding differences between the groups. The short-term outcomes including the rate of successful conservative management without surgery, the period until the first stool, the period of ileus tube intubation, the total period of hospital admission, and adverse events due to gastrografin administration were evaluated and compared between the two groups.
Results: This study included 152 patients: 67 in the EGA group and 85 in the NEGA group. Fifty-five pairs were matched with similar background characteristics. After matching, the rates of successful conservative management were 89.1% (49/55) and 94.5% (52/55) in the matched EGA and NEGA groups, respectively (P=0.49). Although the median insertion days of ileus tube in the NEGA group were significantly lesser than those in the EGA group (7 [5–9] vs. 5 [4.5–7], P=0.017), other therapeutic outcomes did not differ significantly. In the NEGA group, 5.5% (3/55) achieved obstruction relief without gastrografin administration. Aspiration pneumonia occurred in one patients of EGA group.
Conclusions: Gastrografin administration with ileus tube achieved a high rate of successful conservative management. Follow-up by decompression with ileus tube for at least 48 h after admission is required in patients with ASBO, which may avoid unnecessary gastrografin administration and consequently reduce the total cost of treatment.
HOXB4 promotes the malignant progression of ovarian cancer via DHDDS
Authors: Li Na , Xiong Jiao , Li Zhengyu 
Published: February 2020

Abstract
Background : Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear. Methods : The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. The biological functions of HOXB4 were confirmed by colony formation, migration, and invasion assays. The effect of HOXB4 on the expression of EMT cell markers was determined. The transcriptional target of HOXB4 was DHDDS, which was detected by a ChIP assay. A xenograft tumor model was generated in nude mice to detect the role of HOXB4 in tumor proliferation and metastasis. Results : The results showed that HOXB4 protein levels were higher in OV tissues than in normal tissues and correlated with poor prognosis of OV. HOXB4 reduction inhibited the proliferation and invasion ability of OV cells in vitro. Conversely, these effects were enhanced by the upregulation of HOXB4 in OV cells. The binding of HOXB4 to two DNA motifs regulated DHDDS expression and contributed to the malignant progression of OV. The role of HOXB4 in contributing to tumor development in vivo was verified in mice. Further results indicated that HOXB4 induced Snail and Zeb1 expression. Conclusion : Overall, HOXB4 overexpression was remarkably correlated with poor prognosis of OV. Mechanistically, HOXB4 enhances the proliferation and invasion of tumor cells by activating DHDDS, thereby promoting the malignant progression of OV.
Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model
Authors: Gao Shifang , Li Huihui , Xie Hong , Wu Shili , Yuan Yuan , Chu Liang , Sun Siying , Yang Huijuan , Wu Lingqin , Bai Yongsheng , Zhou Qiao , Wang Xin , Zhan Bin , Cui Hu , Yang Xiaodi 
Published: February 2020

Abstract
Background Myocardial dysfunction is one of the most common complications of multiple organ failure in septic shock and significantly increases mortality in patients with sepsis. In spite of many studies have confirmed that helminth-derived proteins have strong immunomodulatory functions and could be used to treat inflammatory diseases, there is no report on the therapeutic effect of Schistosoma japonicum -produced cystatin ( Sj- Cys) on the sepsis-induced cardiac dysfunction. Methods A model of sepsis-induced myocardial injury was established by cecal ligation and puncture (CLP) in mouse. Upon CLP operation, each mouse was intraperitoneally treated with 10 µg of recombinant Sj -Cys (r Sj -Cys). Twelve hours after CLP operation, the systolic and diastolic functions of left ventricular were examined by echocardiography. The levels of myoglobin (Mb), cardiac troponin I (cTnI), N-terminal pro-Brain Natriuretic peptide (NT-proBNP) in sera and the activity of myeloperoxidase (MPO) in cardiac tissues were examined as biomarkers for heart injury. The heart tissue was collected for checking pathological changes, macrophages and pro-inflammatory cytokine levels. To address the signaling pathway involved in the anti-inflammatory effects of r Sj -Cys, myeloid differentiation factor 88 (MyD88) was determined by Western blot in heart tissue of mice with sepsis and LPS-stimulated H9C2 cardiomyocyte cells. In addition, the therapeutic effects of r Sj -Cys on LPS-induced cardiomyocyte apoptosis were also detected in H9C2 cells.The levels of M1 biomarker iNOS and M2 biomarker Arg-1 were detected in heart tissue. The pro-inflammatory cytokines TNF-α and IL-6 and regulatory cytokines IL-10 and TGF-β were measured in sera and their mRNA levels in heart tissue of r Sj -Cys-treated mice. Results After being treated with r Sj -Cys, the sepsis-induced heart malfunction was largely improved. The inflammation and injury of heart tissue were also significantly alleviated characterized by significantly decreased infiltration of inflammatory cells in cardiac tissues and fiber swelling, reduced levels of Mb, cTnI and NT-proBNP in sera and MPO activity in heart tissue. The therapeutic efficacy of r Sj -Cys is associated with down-regulated pro-inflammatory cytokines (TNF-α, IL-6) , as well as the decreased M1 macrophages and increased M2 macrophages, possibly through inhibiting LPS-MyD88 signal pathway. Conclusions Recombinant Sj -Cys significantly reduced sepsis-induced cardiomyopathy and could be considered as be a potential therapeutic agent for the prevention and treatment of sepsis associated cardiac dysfunction.
Incisional Negative Pressure Wound Therapy Dressing in Total Joint Arthroplasty: what is the evidence? A Meta-Analysis
Authors: Wei Wen-Xing , Zeng Yi , Liu Yuan , Li Ming-Yang , Wu Yuan-gang , Shen Bin 
Published: February 2020

Abstract
Background The purpose of this study is to evaluate whether incisional negative pressure therapy dressing (iNPWT) has an advantage over conventional wound dressing (CWD) on wound healing for patients with total joint arthroplasty (TJA) Methods We searched the electronic databases including PubMed, The Cochrane Library, EMBASE via Ovid SP, Medline via Ovid SP, to screening published randomized controlled trials and high-quality cohort studies reported that incisional negative pressure therapy dressing applied in hip and knee arthroplasty. We analyzed the overall complications, major and minor complications, dressing changes, infection rate, and the rate of reoperation. The relevant data was analyzed by RevMan5.3. Results Six studies met our criteria, and included 1405 incisions in 971 participants with total joint arthroplasty which were randomized either to incisional negative pressure therapy dressing group (n=578) or to conventional wound dressing group (n=827) .The risk for developing a minor complication between two groups was not significantly different (risk ratio [RR] 0.58, p =0.40) and for major complication was also not significantly different (RR 0.71, p =0.39). In terms of dressing changes, the iNPWT was fewer than the control group ( P <0.05). The effect of rate of infection and reoperation was not significantly different (RR 0.65, p =0.27). Conclusions For patients underwent TJA, applying iNPWT may be associated with fewer dressing change, which maybe mean less exudation. There was no significant difference on the rate of infection and reoperation, and experiencing either minor or major complications between participants in whom iNPWT versus CWD were used for wound. However, more high-quality randomized or non-randomized controlled trials with larger sample sizes and cost-effectiveness analysis are required.
Controlling Nutritional Status (CONUT) score predicts worse outcomes in Chinese cardiac surgery patients
Authors: Yang Yan , Zhang Pei , Zhou Hua , Yang Min 
Published: February 2020

Abstract
Background & Aims: Nutritional and immunological status was assessed by the Controlling Nutritional Status (CONUT) score calculated from serum albumin, total cholesterol and total peripheral lymphocyte count. The aim of this study was to determine the prognostic impact of the CONUT score on patients underwent cardiac surgery.Methods: This is a single-center retrospective observational study in cardiac surgery patients. Baseline characteristics, comorbidities, and laboratory data were collected. The primary outcome was all-cause mortality. The secondary outcomes were postoperative complications including acute kidney injury (AKI), transient ischemic attack or stroke, reoperation for bleeding. Univariate and multivariate Cox regression were performed to investigate the association between confounding factors and outcomes. The cut-off value of CONUT score was accessed by the receiving operating characteristic curve. We used the Kaplan-Meier curve to compare the outcomes according to the cut-off CONUT score. The area under the curve (AUC) was used to test discriminative power of CONUT score and relevant clinical parameters. Results: A total of 408 patients were enrolled in this study. During a median follow-up period of 72.12 months, 28 (6.9%) patients died and 43 (10.5%) patients occurred postoperative complications. The rate of all-cause mortality and postoperative complications was higher in the high CONUT score (>3) group than in the low CONUT score group (p=0.002, p=0.02). High CONUT score (hazard ratio [HR] =2.367, 95% confidence interval [CI]=1.072 to 5.266, P=0.033) was an independent predictor of all-cause mortality. The AUC of the joint probability of CONUT score, age, and hypertension in predicting all-cause mortality was 0.744 (95% CI: 0.687–0.775). The high CONUT score was still an independent risk factor of secondary outcomes (HR=2.316, 95%CI=1.122 to 4.780, P=0.023).Conclusion: The CONUT score was independently associated with all-cause mortality and postoperative complications in patients underwent cardiac surgery.
Secular trend in dietary patterns of Iranian adults from 2006 to 2017: Tehran Lipid and Glucose Study
Authors: Aghayan Maryam , Asghari Golaleh , Yuzbashian Emad , Mahdavi Maryam , Mirmiran Parvin , Azizi Fereidoun 
Published: February 2020

Abstract
Background: by focusing on nutrition transition in the Middle East and North Africa, this study aim to investigate the general structure and secular trend of dietary patterns extracted from the Tehran Lipid and Glucose Study (TLGS) and adherence to these dietary patterns among Iranian population from 2006 till 2017.Methods: We investigated on four examination surveys of TLGS including survey 1 (2006-2008), survey 2 (2009-2011), survey 3 (2012-2014), and survey 4 (2015-2017). The dietary intakes was gathered by a validated and reliable food frequency questionnaire. Generalized Estimating Equations was used to assess secular trends in anthropometric, biochemical, and dietary variables across the study period. To identify general structure and secular trend of dietary patterns during each survey, principle component analysis (PCA) and K-mean cluster analysis were used, respectively.Results: After adjusting for potential confounders including age, sex, body mass index, and total energy intake, the carbohydrate and protein intake gradually increased and the total fat intake decreased during study period (P-value<0.001); however total energy intake remained stable. During the study period, participants consumed notable less refined grain, solid fat, dairy products, and simple sugar. Snack and dessert consumption increased and meat intake had no significant changes during a decade (all P-values<0.001). Three dietary patterns were extracted buy using PCA including: Healthy dietary pattern characterized by higher intake of vegetable, fruit, dairy products, liquid oil, nuts and seeds, and honey and jam, Western dietary pattern featured by refined grain, solid fat, meat, snack and dessert, potato, and soft drink, and the Mixed dietary pattern highlighted by tea and coffee, and simple sugar. Based on cluster analysis, 27.8% of participants in survey 4 followed a Western dietary pattern, and 34.1% followed the Mixed dietary pattern. The Healthy dietary pattern was stable among study population during the last decade.Conclusions: The structure and the type of foods that population have chosen to eat had changed since 2006. And a new secular trend in dietary patterns including a stability of Healthy dietary pattern, a decline of the Western dietary pattern and an increase in the Mixed dietary pattern was presented in our investigation.
Orthogonal Approach to Independent Component Analysis Using Quaternionic Factorization
Authors: Borowicz Adam 
Published: February 2020

Abstract
Independent component analysis (ICA) is a popular technique for demixing multi-channel data. The performance of typical ICA algorithm strongly depends on many factors such as the presence of additive noise, the actual distribution of source signals, and the estimated number of non-Gaussian components. Often a linear mixing model is assumed and the source signals are extracted by proceeding data whitening followed by a sequence of plane (Jacobi) rotations. In this article, we develop a four-unit, symmetric algorithm, based on the quaternionic factorization of the rotation matrices and the Newton-Raphson iterative scheme. Unlike conventional rotational techniques such as the JADE algorithm, our method exploits 4 x 4 rotation matrices and uses negentropy approximation as a contrast function. Consequently, the proposed method can be adapted to a given data distribution (e.g. super-Gaussians) by selecting the appropriate non-linear function that approximates the negentropy. Compared to the widely used, symmetric FastICA algorithm, the proposed method does not require an orthogonalization step and offers better numerical stability in the presence of multiple Gaussian sources.
Expression of ST6GalNAc1 and sialyl-Tn antigen enhances endometrial receptivity
Authors: Choi Hee-Jung , Chung Tae-Wook , Kim Jihyun , Kim Bo-Sung , Park Mi-Ju , Kim Keuk-Jun , Joo JongKil , Kim Cheorl-Ho , Jun Jin Hyun , Ryu Dongryeol , Ha KiTae 
Published: February 2020

Abstract
BackgroundTo characterize molecular mechanism underlying the regulation of sialylated glycan expression and its roles for endometrial receptivity and embryo implantation. Here, we characterized the role of a truncated form of sialylated O-glycan, sialyl-Tn, for endometrial receptivity.MethodsThe transcriptomes of human endometrium at mid-secretory phase were analyzed by Bioinformatics. Changes in gene expression, protein, and signal pathway were measured using RT-PCR and Western blot. The cell adhesion assay was visualized using a fluorescent microscope. In peri-implantation phase of mice, the expression of leukemia inhibitory factor (LIF) and sialyl-Tn were confirmed using immunohistochemistry and immnofluorescence analysis. The effect of sialy-Tn expression on embryo implantation was estimated by in vitro fertilization and embryo transfer using mice.ResultsIn in silico analysis, expression of O-glycosylation genes, especially ST6GalNAc1, was significantly increased in the human uterus of mid-secretory phase. Overexpression of the ST6GalNAc1 gene in non-receptive human endometrial AN3CA cells enhances the attachment of trophoblastic JAr cells. In an animal study, the results clearly indicated that sialyl-Tn was expressed on the surface of the mid-secretory uterus. In addition, blockade of the receptor using free sialyl-Tn epitope diminished the implantation rates of intrauterine transferred murine embryos.ConclusionFrom these results, here we suggest that sialyl-Tn expression might be a novel factor regulating the endometrial receptivity for successful embryo implantation.
Strain pattern of each ligamentous band of the superficial deltoid ligament
Authors: Takao Masato , Ozeki Satoru , Oliva Xavier Martin , Inokuchi Ryota , Yamazaki Takayuki , Takeuchi Yoshitaka , Kubo Maya , Lowe Danielle , Matsui Kentaro , Katakura Mai , Glazebrook Mark 
Published: February 2020

Abstract
Background There are few reports in terms of detailed biomechanics of the deltoid ligament, and no reports have measured the biomechanics of each ligamentous band, due to the difficulty in inserting sensors into the narrow ligaments. This study aims to measure the strain pattern of the deltoid ligament bands using a miniaturization ligament performance probe (MLPP) system. Methods The MLPP was sutured into the ligamentous bands of the deltoid ligament in 6 fresh-frozen lower extremity cadaveric specimens. The strain was measured using a round metal disk (clock) fixed on the plantar aspect of the foot. The ankle was manually moved from 15° of dorsiflexion to 30° plantar flexion, and a 1.2-N-m force was applied to the ankle and subtalar joint complex. The clock was then rotated every 30° to measure the strain of each ligamentous band at each endpoint. Results The tibionavicular ligament (TNL) begins to tense at 10° plantar flexion and the tension becomes stronger as the angle increases; the TNL works most effectively in plantar flex-abduction. The tibiospring ligament (TSL) begins to tense gradually at 15° plantar flexion and the tension becomes stronger as the angle increases. The TSL works most effectively in the abduction. The tibiocalcaneal ligament (TCL) begins to tense gradually at 0° dorsiflexion, and the tension becomes stronger as the angle increases. The TCL works most effectively in pronation (dorsiflexion-abduction). The superficial posterior tibiotalar ligament (SPTTL) begins to tense gradually at 0° dorsiflexion, and the tension becomes stronger as the angle increases, with the SPTTL working most effectively in dorsiflexion. Conclusion Our results provide a better understanding of the biomechanical function of the superficial deltoid ligament and could help in improving repair and reconstruction procedures.
The clinical prediction factors of nonculprit lesions progression in patients with acute ST elevation myocardial infarction after primary percutaneous coronary intervention
Authors: wang jian , WANG Xue-Jie 
Published: February 2020

Abstract
Objective :To investigate the relationship between the clinical features and progression of nonculprit lesions in patients with ST-elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI). Methods: A total of 192 patients (57.1 ± 9.2 years) with STEMI who underwent PPCI from January 2016 to December 2017 in Beijing Anzhen Hospital were enrolled in this study. All patients underwent PPCI as treatment for culprit lesions.Clinical and angiographic follow-up were performed in 12 months. All patients were divided into Nonculprit lesions(NCL) progression group ( 82 cases) and the control group (110 cases) according to angiographic follow-up outcome in 12 months. The clinical and angiographic features were analyzed.Results: Levels of body mass index（BMI）,serum creatinine（Scr）,fasting blood glucose（FBG）,glycated serum albumin（GSA）,glycated hemoglobin(GHb) and homocysteine (Hcy) in NCL progression group were significantly higher than those in the control group( P < 0. 05,respectively).Logistic regression showed that FBG( odds ratio = 1. 274,95% confidence interval: 1. 077-1. 505,P = 0. 005) and Scr ( odds ratio =1. 020,95% confidence interval:1. 002-1. 038,P=0. 027) were independent predictors of NCL progression.Partial correlation analysis showed that FBG was positively correlated with NCL progression( r = 0. 231,P = 0. 001) .Receiver operating characteristic(ROC) curve showed that the boundary point of FBG to predict NCL progression was 5. 715 mmol /L, the sensitivity was 74. 4% and the specificity was 46. 4%.Conclusion: FBG is an valuable predictor for NCL progression in patients with STEMI after PPCI.
A score of non-contrast transthoracic echocardiography to detect patent foramen ovale
Authors: Zhang Hui , Tang Haiyan , Wu Fei , Yu Chun , Dong Qiang , Cao Wenjie 
Published: February 2020

Abstract
Backgroud: The aim of this study was to develop a screening score of non-contrast transthoracic echocardiography (TTE) for patent foramen ovale (PFO) in patients with embolic stroke of undetermined source (ESUS).Methods: We performed a retrospective analysis of 218 consecutive patients with a recent ESUS from 2015 to 2018, who received TTE and transcranial Doppler (TCD) as routine examinations. PFO was diagnosed by the bubble test of TCD. Significant differences of the TTE findings between PFO group and non-PFO group were selected into a score.Results: PFO was diagnosed in 35.8% (78/218) of the patients. Compared with non-PFO group, a larger median aortic root diameter (ARd) (34mm vs. 32mm, p=0.005), a lower median peak E wave velocity (Em) (61.5cm/s vs. 68cm/s, p=0.005) and a lower incidence rate of mitral regurgitation (33.8% vs. 50.7%, p=0.016) were seen in PFO group. A three-point score of TTE criteria (including aortic root diameter>33mm, Em<72cm/s and without mitral regurgitation, AEM) was tested to be independently predict PFO (odd risk 1.95, 95%CI 1.37~2.78, p<0.001). AEM score ≥2 detected PFO with a sensitivity of 0.71 (95% CI 0.67~0.85) and a specificity of 0.53 (95% CI 0.44 - 0.55).Conclusion: The AEM score measured with non-contrast TTE can select ESUS patients for bubble test of TCD to detect PFO.