bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel biomarker TLCD1 correlates with prognosis and immune infiltrates in hepatocellular carcinoma
Authors: Shen Hanyu , Ren Shiqi , Tang Chenyu , Duan Lian , Wang Wei , Gao Xuyang , Sun Pingping , Wang Ziheng , Duan Yinong 
Published: April 2020

Abstract
Background The HCC has seen a spike in the morbidity and the mortality rate in recent times. This calls for an urgent understanding of the underlying molecular mechanisms of the HCC and to speed up the quest for the search of the target molecules to ensure quick diagnosis and prognosis subsequently. TLCD1 is a gene only reported in membrane fluidity. The variations in the TLCD1 expression levels related to the infiltration of the immune cells in HCC and the prognosis shall be examined initially. Methods The data received from TCGA shall provide the details of the gene expression, clinicopathology analysis and immune infiltration, along with the enrichment analysis. Moreover, we also performed additional analysis of the bioinformatics available. The immune responses of TLCD1 expression in HCC were analyzed using CIBERSORT and TIMER, while the statistical analysis was handled through R. Results Higher TLCD1 expression is strongly correlated with a poor prognostic and worse overall survival. Specifically, the increase in TLCD1 expression positively correlated with Tregs cells and T cells CD4 memory resting. The pathways strongly associated with TLCD1 was fatty acid metabolism and PPAR signaling pathway. Conclusions From the outcome of the study, it could be surmised that TLCD1 could be considered as a potential target for future treatment of HCC, as it was observed to be associated with the tumor-infiltrating immune cells in tumor microenvironment, establishing itself as a novel potential prognostic biomarker in HCC.
Destruction of secondary Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
Authors: Friani Gabriela , Costa Valdir Almeida da , Mota Ester , Faro Marta Julia , Souza Samaly , Figueiredo Marcela , Golo Patricia , Mello-Silva Clélia Christina 
Published: April 2020

Abstract
Background: Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni . The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni .Methods: Uninfected and infected snails were exposed to sublethal concentrations of E. milii latex for 24 hours (1.0 mg/l less than the LC 50 ) and after this time were analysed.Results: The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni , the exposure to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland, kidney and ovotestis. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. Proliferation of hemocytes in the kidney and digestive gland and edema in the mantle area were also observed in the uninfected and exposed snails. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells, and in all the groups the proportion of hyalinocytes was higher than the other types. There was no significant difference among the cell types and the different groups analyzed. Conclusions: We conclude that the sublethal concentration of E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni , promoting the destruction of parasites.
The Influence of Similarity Vocabulary on New Vocabulary Learning in Indonesian for Taiwanese Students
Authors: Lase Apriliana 
Published: April 2020

Abstract
This study investigated the new vocabulary effect to remember the old vocabulary in task reading Indonesia as a second language. The similarity of vocabulary related to Phonological neighborhood by giving two pretest and posttest methods in two groups and presenting a control group to be able to see how far the ability of students to understand related vocabulary. The task in the form of reading shows an image. The Lexicon neighbor is constrained because of the similar word can affect the memory of students. The problem of students they have limited time to finish the task of reading — the issue of student they found when running the experiment.
Identification the prognostic value of immune gene signature and infiltrating immune cells of esophageal cancer patients
Authors: Wang Lin , Wei Qian , Zhang Ming , Chen Lianze , Li Zinan , Zhou Chenyi , He Miao , Wei Minjie , zhao lin 
Published: April 2020

Abstract
Background Esophageal cancer (ESCA) is one of the deadliest solid malignancies with worse survival in the world. The poor prognosis of ESCA is not only related to malignant cells, but also affected by the microenvironment. We aimed to establish prognostic signature consisting of immune genes to predict the survival outcome of patients and estimate the prognosis value of infiltrating immune cells in tumor microenvironment (TME). Methods Based on integrated analysis of gene expression profiling and immune gene database, differentially immune-related genes were filtered out. Then, stepwise Cox regression analysis was applied to identify survival related immune genes and construct prognosis signature. Functional enrichment analysis was performed to explore biology function. Kaplan-Meier (K-M) curves and receiver operating characteristic (ROC) curves were performed to validate the predictive effect of predictive signature. We also verified the clinical value of prognostic signature under the influence of different clinical parameters. For deeper analysis, we evaluated the correlation between prognosis signature and infiltrating immune cells by Tumor Immune Estimation Resource (TIMER) and CIBERSORT. Results Finally, we identified 303 differentially immune genes as candidate and constructed immune prognosis signature composed of six immune genes. Furthermore, we observed that the prognosis signature was enriched in cytokine-mediated signaling pathway, lymphocyte activation, immune effector process, cancer pathway, NF-kappa B signaling pathway. K-M survival curves showed that the prognosis signature indeed have good predictive ability in entire ESCA set ( P =0.003), validation set 1 ( P =0.008) and validation set 2 ( P =0.036). The area under the curve (AUC) of ROC curves validated the predictive accuracy of immune signature in three cohorts (AUC=0.757, 0.800 and 0.701), respectively. In addition, we identified the prognosis value of infiltrating-immune cells including activated memory CD4 T cells, T cells follicular helper cells and monocytes and provided a landscape of TME. Conclusions The results indicated that immune prognosis signature can be a novel biomarker to predict survival outcome, which can provide new targets for immunotherapy and individualized therapies in ESCA and open up a new prospect for improving the prognosis of ESCA patients in the era of immunotherapy.
Radiological Features on HRCT and RT-PCR Testing for the Diagnosis of Coronavirus Disease 2019 (COVID-19) in China: A Comparative Study of 78 Cases in Pregnant Women
Authors: Deng Ming , Sun Wenbo , Hu Jinxiang , Mei Liejun , Weng Dinghu , Liu Bo , Xu Haibo 
Published: April 2020

Abstract
Objective: We aimed to evaluate the quantitative parameters of CT scans performed on pregnant women with COVID-19 who had different reverse transcription-polymerase chain reaction (RT-PCR) results.Methods: Pregnant women with suspected cases of COVID-19 pneumonia (confirmed by next-generation sequencing or RT-PCR) who underwent high-resolution lung CT scans were retrospectively enrolled. Patients were grouped based on the results of the RT-PCR and the first CT scan: group 1 (double positive patients; positive RT-PCR and CT scan) and group 2 (negative RT-PCR and positive CT scan). The imaging features and their distributions were extracted and compared between the two groups.Results: Seventy-eight patients were admitted to the hospital between Dec 20, 2019, and Feb 29, 2020. The mean age of the patients was 31.82 years (SD 4.1, ranged from 21 to 46 years). The cohort included 14 (17.95%) patients with a positive RT-PCR test and 64 (82.05%) with a negative RT-PCR test, there were 37 (47.44%) patients with a positive CT scan, and 41 (52.56%) patients with a negative CT scan. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CT-based diagnosis of COVID-19 were 85.71%, 60.94%, 32.40%, 95.12% and 65.38%, respectively. COVID-19 pneumonia mainly involved the right lower lobe of the lung. There were 53 semi-quantitative and 59 quantitative parameters, which were compared between the two groups. There were no significant differences in the quantitative parameters. However, the Hellinger distance was significantly different between the two groups, albeit with a limited diagnostic value (AUC=0.63).Conclusions: Pregnant women with pneumonia usually present with typical abnormal signs on CT. Although multidimensional CT quantitative parameters are somewhat different between groups of patients with different RT-PCR results, it is still impossible to accurately predict whether the RT-PCR will be positive, which would allow for the earlier detection of SARS-CoV-2 infection.
Using Floquet Theory in the Procedure for Investigation of the Motion Stability of a Rotor System Exhibiting Parametric and Self-Excited Vibration
Authors: Ferfecki Petr , Zaoral Filip , Zapoměl Jaroslav 
Published: April 2020

Abstract
The computational procedure for investigation vibration stability of a flexible rotor consisting of an asymmetric shaft, one disc, and supported by ball bearings is developed in this work. Lagrange equations of the second kind were used for derivation of the motion equation. The vibration response stability of the Jeffcott-like rotor was studied by means of eigenvalues of a transition matrix. Three different methods for approximation of the transition matrix have been investigated. The presented simulations are focused on studying the influence of parametric excitation produced by the shaft asymmetry and self-excitation vibration caused by the shaft material damping. The numerical results proved the applicability of the developed procedure, which has been verified by the direct integration of the motion equation.
Analysis of Impact Behaviour of TIG Weldment by Using Hybrid RSM and CSO
Authors: Chandra Moi Subhas , Ramesh Rudrapati , Kumar Pal Pradip , Asish Bandyopadhyay 
Published: April 2020

Abstract
Tungsten inert gas (TIG) welding is a multi-input and multi-output variant process. The input process parameters and other factors of welding process interact in a complicated manner and influence the weld quality – directly or indirectly. Keeping this in mind, the present work has been planned to study the impact behaviour of TIG weldment through experiments, analysis and optimization. Experimental runs have been considered as per Box-Behnken design of response surface methodology (RSM). Based on the recorded data, the mathematical models have been developed to study the effect of process parameters on impact strength. ANOVA has been utilized to identify the influence of input process parameters on the response i.e. impact strength. RSM and cuckoo search optimization (CSO) algorithm have also been applied to optimize the impact strength.
Parametric Analysis of Electrochemical Discharge Drilling on Soda-Lime Glass Material Using Taguchi L27 Orthogonal Array Method
Authors: Pawar Pravin , Kumar Amaresh , Ballav Raj 
Published: April 2020

Abstract
The Electrochemical discharge machining (ECDM) is a hybrid non-traditional process which is specifically used for machining of conducting as well as non-conducting materials. In this research work, the fabricated ECDM experimental setup was used to machine the Soda-lime glass material with Brass tool material. The experiments were done on Soda-lime glass material with the help of Taguchi L27 orthogonal array method and analysed by using MINITAB 17 software. The average hole diameter and average machined depth results were checked after ECDM drilling on Soda-lime glass material with considering the input process parameters such as an electrolyte concentration, voltage and rotation. The experimental results indicated that voltage was the most dominant factor for average machined depth followed by an electrolyte concentration and rotation speed. The rotation speed was the most dominant factor for average hole diameter followed by voltage and electrolyte concentration.
Role of Ultrasound Acoustic Radiation Force Impulse in Differentiating Benign from Malignant Superficial Lymph Nodes
Authors: Chanda Reettika , Kandagaddala Madhavi , Moses Vinu , Sigamani Elanthenral , Keshava Shyamkumar Nidugala , Janakiraman Rajinikanth 
Published: April 2020

Objective:
The purpose of this study was to evaluate the diagnostic performance of acoustic radiation force impulse (ARFI) imaging in differentiating benign from malignant peripheral lymphadenopathy.

Materials and Methods:
This was a prospective study approved by the Institutional Review Board with financial grant for the same. Ultrasound and ARFI imaging of peripheral lymph nodes were performed and correlated with pathological results, which were used as the reference standard. The virtual touch tissue imaging and virtual touch tissue quantification parameters of ARFI were analyzed in 86 lymph nodes, of which 78 were included in the study. Using receiver operating characteristic curve analysis, the diagnostic usefulness of ARFI values were evaluated with respect to their sensitivity, specificity, and area under the curve.

Results:
The mean area ratio of benign lymph nodes was 0.88 (±0.2) and that of malignant lymph nodes was 1.17 (±0.14). The mean shear wave velocities (SWV) of benign and malignant lymph nodes were 2.02 m/s (±0.94) and 3.7 m/s (±2.27), respectively. The sensitivity and specificity of virtual touch imaging area ratio in differentiating benign from malignant lymph nodes was 97% and 77%, of SWV was 71% and 70%, and of SWV ratio was 68% and 79%, respectively.

Conclusion:
As ARFI was found to have a superior diagnostic performance over conventional ultrasound and color Doppler in the characterization of lymph nodes, we recommend its routine use in differentiating benign from malignant nodes.
Dallı Servi ve Piramit Servi’nin Morfolojik Fidan Özellikleri
Authors: USLU Murat , BİLİR Nebi 
Published: April 2020

1+0 yaşlı çıplak köklü
Dallı ve Piramit servi de fidan morfolojisi ve kalitesinin araştırıldığı bu
çalışmada, ortalama fidan boyu ve kök boğazı çapı değerleri sırasıyla Dallı
servide (Cupressus sempervirens L.
var. horizontalis) 84 cm ve 8,7 mm;
Piramit servide (Cupressus sempervirens
L. var. piramidalis) 78,9 cm ve 8,2
mm bulunmuştur. Fidan boyu ve kök boğazı çapı bakımından Dallı servi Piramit
serviye göre daha yüksek performans göstermiştir. Uygulanan varyans analizi sonucunda fidan boyu ve
kök boğazı çapı bakımından taksonlar arası anlamlı (p≤0.05) fark ortaya çıkmıştır.
Korelasyon analizi sonucunda her iki
taksonda da; fidan boyu ile kök boğazı arasındaki istatistiksel
bakımdan anlamlı (p≤0.05) pozitif
ilişkiler (r=0.299, r=0.255 ve r=0.308) belirlenmiştir. Değerlendirmeler sonucunda her iki
taksonda da boy ve çap bakımından fidanların tamamının Türk Standartları
Enstitüsü’nün kalite sınıflarına göre kaliteli fidan sınıfında yer aldığı
ortaya çıkmıştır. Çalışma kapsamında taksonlara göre oluşturulan yeni kalite sınıflarında; Dallı servi de en yüksek dikime
elverişsiz fidanların fidan boyu ve kök boğazı çapının birlikte
değerlendirildiği kalite sınıflarında (%36,7 ve %26,7) olduğu belirlenmiştir. Uygulanan
ayırma analizi sonucunda bu yeni kalite sınıflarının, %82- %98 arasında değişen
oranlarda başarılı olduğu görülmektedir.
Piramit servide ise oluşturulan yeni kalite
sınıflarına göre, dikime elverişsiz fidanların fidan boyu ve kök boğazı çapının
birlikte değerlendirildiği kalite sınıflarında (%42,7 ve %52,7) yer aldığı
anlaşılmıştır. Ayırma analizi sonucunda, yeni kalite sınıflarının, %80,0-
%96,7 arasında değişen oranlarda başarılı olduğu ortaya çıkmıştır.
Пряма і обернена задача визначення параметрів критеріальних рівнянь, отриманих на основі Пі – теореми теорії подібності
Authors: Дубницький В.Ю. , Кобилін А.М. , Кобилін О.А. 
Published: April 2020

Визначено поняття систем, які можна фізично реалізувати, як таких систем, що представлені сукупністю фізичних елементів, структурно пов'язаних між собою, і які взаємодіють із зовнішнім середовищем. Для їх дослідження запропоновано використання критеріальних рівнянь, складених на основі Пі – теореми теорії подібності. Показано, що виходячи з вимог теорії подібності ці рівняння співпадають з функцією Кобба – Дугласа. Сформульовану пряму та обернену задачу визначення параметрів критеріальних рівнянь. Пряма задача визначення параметрів критеріальних рівнянь співпадає з задачею ідентифікації функції Кобба – Дугласа. В нашому випадку функцією та аргументами слугують відповідні безрозмірні величини – критерії подібності. Для розв’язання прямої задачі необхідно за даними експерименту з фізичною моделлю технічної системи визначити чисельні параметри цієї функції подібності. Для розв’язання цієї задачі використано алгоритм Марквардта. Пряма задача може бути використана в процесі аналізу технічної системи. Обернену задачу визначення параметрів критеріальних рівнянь можна розглядати як задачу синтезу технічної системи. Для її розв’язання запропоновано двохетапну процедуру. На першому етапі визначають необхідні значення критеріїв – аргументів, на другому визначають безпосередньо значення фізичних параметрів системи, необхідних для забезпечення чисельної величини обраного критерію подібності. Для розв’язання оберненої задачі використано метод дослідження простору параметрів. Наведено чисельний приклад застосування викладеної методики.
Peran Tu’a Ulayat Warloka Dalam Penyelesaian Sengketa Tanah
Authors: Sundara Komang , Gani Abdul 
Published: April 2020

Konflik tanah komunal akan berdampak rusaknya hubungan kekeluargaan, konflik yang panjang menyebabkan kerugian materi, tenaga dan ekonomi serta pikiran. Desa Warloka merupakan salah satu desa yang tanah ulayat ataupun tanah masyarakat sering menimbulkan sengketa. Tujuan penelitian untuk mendeskripsikan peran tu’a ulayat dalam penyelesaiannya. Metode penelitian dengan kualitatif dengan pendekatan deskriptif. Sumber data yang dipakai menggunakan data perimer dan sekunder. Subyek penelitiannya Tu’a Ulayat (tua teno), kepala desa, tokoh masyarakat, dan masyarakat yang bersengketa. Mengumpulkan data menggunakan metode wawancara dan dokumentasi. Analisis data deskriptif kualitatif dengan langkah analisis reduksi data, penyajian data dan verifikasi atau penarikan kesimpulan. Pengujian keabsahan data dengan uji credibility, depenability, dan confirmability. Hasil penelitian menunjukkan peran Tu’a Ulayat dalam menyelesaikan sengketa tanah cukup baik karena proses penyelesaian meliputi tahapan mediator, olah tempat perkara, musyawarah dan mufakat dan pengambilan keputusan. Tahapan-tahapan tersebut sangat membantu ketua adat dalam mendamaikan kedua pihak sengketa tanah. Jadi adanya Tu`a Ulayat mampu meminimalisirkan penyelesaian sengketa tanah di masyarakat Warloka.Communal land conflicts will have an impact on family relationships, long conflicts causing material, energy and economic loss and thought. The village of Warloka is one of the villages that soil or community land often pose disputes. Research aims to describe the role of Ulayat Tu'a in completion. Qualitative method of research with a descriptive approach. The data source used uses Perimer and secondary data. Subjects of his research are Tu'a Ulayat (old Teno), village head, community leaders, and disputed society. Collects data using interview methods and documentation. Analysis of qualitative descriptive data with analysis steps of data reduction, data presentation and verification or withdrawal of conclusions. Testing the validity of data with test credibility, depenability, and confirmability. The results showed the role of Tu'a Ulayat in resolving land disputes well enough because the completion process includes the stage of the mediator, the place of matter, deliberation and consensus and decision making. These stages are very helpful to the customary chairman in reconciling both parties to the land dispute. So the existence of Tu'a Ulayat able to minimize the settlement of land disputes in the Society of Warloka.
Study on the proposal of a community of freshwater aquaculture and vegetable farming in An Giang
Authors: Nguyen Thu Hong Anh , Thi Hieu Tran , Van Tung Tra , Viet Thang Nguyen , Nguyen Huyen Khon , Quoc Vi Le , Thi Phuong Thao Nguyen , Thanh Hai Le 
Published: April 2020

The objective of this study is to propose models of livelihoods symbiosis between freshwater aquaculture operations and vegetable farming. This model functioned as the way to reuse water and nutrients discharged from aquaculture activities, which caters for vegetable farming. The efficiency of the model is to minimize a large amount of solid waste disregarded directly to the receiving source, which was 315.098 kg. The quality of wastewater had been improved after releasing to the source. Total amount of carbon (TOC), nitrogen and phosphorus was 7.56%, 8.27% and 0.64% respectively, all of which meet the standard index of waste disragrded directly into the environment. In addition, the model also brings the additional income for households with 24.9 million VN dong after every fish breeding in comparison with traditional farming model.
ПОГРОМИ, НАСИЛЛЯ НАТОВПУ ТА ГЕНОЦИД У ЗАХІДНІЙ УКРАЇНІ ВЛІТКУ 1941: ІСТОРІЯ, ПОЯСНЕННЯ ТА ПОРІВНЯННЯ
Authors: Lower Wendy , Piskarеv Yaroslav 
Published: April 2020

У цьому есе авторка оприлюднює нові дослідження, а також розглядає існуючі інтерпретації історії погромів в Україні під час Голокосту. Зосереджуючи увагу на подіях у Західній Україні влітку 1941 р., дослідниця стверджує, що євреї були основними об’єктами переслідувань у регіоні, проте політика та рушійні сили як громадського насилля, так і окупаційних сил змінювалися залежно від місцевості. Окрім потужного антисемітського заряду «жидобільшовизму», авторка досліджує також інші політичні, соціальні, психологічні та ідеологічні причини насильства. Вона звертає увагу на зріз суспільства, представлений серед погромників, а також на роль націоналістичних повстанців і німецьких окупантів. Авторка відслідковує відношення між масовими розстрілами, що їх провадили нацисти, та погромами, і стверджує, що відмінності між насиллям натовпу та геноцидом зазвичай не враховують зміну взаємодії цих двох явищ. Перетин та висока динаміка їх історії особливо помітні на Західній Волині, де, на відміну від сусідньої Галичини, кількість загиблих у масових розстрілах євреїв перевищувала кількість тих, хто загинув від погромів. Таким чином, наприкінці вересня 1941 р. у східній столиці, Києві, не було великих погромів, на зразок львівських «днів Петлюри», натомість був Бабин Яр.