bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular analysis of 76 Chinese hemophilia B pedigrees and the identification of 10 novel mutations
Authors: Huang Limin , Li Liyan , Lin Sheng , Chen Juanjuan , Li Kun , Fan Dongmei , Jin Wangjie , Li Yihong , Yang Xu , Xiong Yufeng , Li Fenxia , Yang Xuexi , Li Ming , Li Qiang 
Published: September 2020

AbstractBackgroundHemophilia B (HB) is an X‐linked recessive inherited bleeding disorder caused by mutations in the F9 gene that lead to plasma factor IX deficiency. To identify the causative mutations in HB, a molecular analysis of HB pedigrees in China was performed.MethodsUsing next‐generation sequencing (NGS) and an in‐house bioinformatics pipeline, 76 unrelated HB pedigrees were analyzed. The mutations identified were validated by comparison with the results of Sanger sequencing or Multiplex Ligation‐dependent Probe Amplification assays. The pathogenicity of the causative mutations was classified following the American College of Medical Genetics and Genomics guidelines.ResultsThe mutation detection rate was 94.74% (72/76) using NGS. Of the 76 HB pedigrees analyzed, 59 causative variants were found in 72 pedigrees, with 38 (64.41%) missense mutations, 9 (15.25%) nonsense mutations, 2 (3.39%) splicing mutations, 5 (8.47%) small deletions, 4 (6.78%) large deletions, and 1 intronic mutation (1.69%). Of the 59 different F9 mutations, 10 were novel: c.190T>G, c.199G>T, c.290G>C, c.322T>A, c.350_351insACAATAATTCCTA, c.391+5delG, c.416G>T, c.618_627delAGCTGAAACC, c.863delA, and c.1024_1027delACGA. Of these 10 novel mutations, a mosaic mutation, c.199G>T(p.Glu67Ter), was identified in a sporadic HB pedigree. Using in‐silico analysis, these novel variants were predicted to be disease‐causing. However, no potentially causative mutations were found in the F9 coding sequences of the four remaining HB pedigrees. In addition, two HB pedigrees carrying additional F8/F9 mutations were discovered.ConclusionThe identification of these mutations enriches the spectrum of F9 mutations and provides further insights into the pathogenesis of HB in the Chinese population.
Contribution to an open problem of Harkness and Shantaram
Authors: Jedidi Wissem , Bouzeffour Fethi , Harthi Nouf 
Published: September 2020

Here, we solve an open problem raised by Harkness and Shantaram in 1969 who obtained, under sufficient conditions, a limit theorem in law for sequences of nonnegative random variables built with the iterated stationary excess operator. More precisely, they considered the distribution function (d.f.) F of a nonnegative random variable X having all moments
finite. The stationary excess operator corresponds to the d.f.
, so that the iterated stationary excess operator (ISEO) at the order n ≥ 2 corresponds to the d.f.
, where
. Let the r.v.
denotes a realization of Fn. Harkness and Shantaram provided sufficient conditions for the existence of a normalizing sequence cn such that the sequence
converges in distribution or, equivalently, Fn(cnx) → G(x) for some d.f. G. This raises a problem of identification the class of possible limits G. We give here a complete answer to this problem through the convergence of families built by the continuous time version of the ISEO and also by size biasing. In this context, we show that

the conditions of Harkness and Shantaram are actually necessary;
continuous time convergence is equivalent to discrete time convergence; and
the only possible limits in distribution G are mixture of exponential with log‐normal distributions.
An inclusive analysis of inductive dielectric and/or metallic discontinuities in a rectangular waveguide
Authors: Aydoğan Ahmet 
Published: September 2020

AbstractAn inclusive method is introduced for the analysis of different types of inductively loaded rectangular waveguides with dielectric and/or metallic obstacles. The proposed method utilizes the efficiency of the generalized scattering matrix (GSM) method on scattering analysis and the flexibility of the method of moments on problem configuration. The inductive metallic discontinuities are treated as a dielectric medium with high conductivity and the scattering analysis is accelerated by several cost reduction attempts in conjunction with GSM method and procedure of method of moments. The examined approach is tested against several structures including a metal insert filter, an H‐plane filter, and a dielectric‐metal obstacle‐loaded waveguide both for the dominant mode region and the double‐mode region. The convergence analyses on the number of calculated modes and the size of the discretized cells in the computational procedure are carried out for a comprehensive explanation of the numerical analysis. The accuracy of the method is compared to commercial software based on the finite element method. The proposed method is particularly competent for the frequency analysis of metallic and inhomogeneous dielectric discontinuities horizontally aligned in cuboid shapes.
Advanced design of higher mode‐based dielectric resonator antenna array featuring high‐gain operation over a large frequency band
Authors: Sarkar Chandreyee , Guha Debatosh , Kumar Chandrakanta 
Published: September 2020

AbstractA higher mode‐based dielectric resonator antenna (DRA) featuring attractive characteristics has been explored and successfully demonstrated for use in wireless industry. In here, an improvised elevated feed platform has been conceived to exploit HEM12δ mode in a cylindrical DRA. An additional filtering mechanism by a selective loading has been introduced to achieve a clean and exclusive HEM12δ resonance. A single unit has been characterized at C‐band based on the available characterization facility and experimentally verified ensuring 22% wide matching bandwidth with as much as 11 dBi peak gain. A practical 2 × 2 array with a corporate feed has been successfully demonstrated. A consistent radiation pattern over about 10% matching bandwidth has been experimentally demonstrated. This ensures a flat peak gain (13‐14 dBi) over the full usable frequency band. This is novel in terms of its pure higher mode operation supporting a wireless system with uniform gain characteristics. Its improved features compared to the earlier designs have been clearly discussed.
Head‐to‐head comparison of cardiovascular MR feature tracking cine versus acquisition‐based deformation strain imaging using myocardial tagging and strain encoding
Authors: Backhaus Sören J. , Metschies Georg , Zieschang Victoria , Erley Jennifer , Mahsa Zamani Seyedeh , Kowallick Johannes T. , Lapinskas Tomas , Pieske Burkert , Lotz Joachim , Kutty Shelby , Hasenfuß Gerd , Kelle Sebastian , Schuster Andreas 
Published: September 2020

PurposeMyocardial feature‐tracking (FT) deformation imaging is superior for risk stratification compared with volumetric approaches. Because there is no clear recommendation regarding FT postprocessing, we compared different FT‐strain analyses with reference standard techniques, including tagging and strain‐encoded (SENC) MRI.MethodsFeature‐tracking software from four different vendors (TomTec, Medis, Circle [CVI], and Neosoft), tagging (Segment), and fastSENC (MyoStrain) were used to determine left ventricular global circumferential strains (GCS) and longitudinal strains (GLS) in 12 healthy volunteers and 12 patients with heart failure. Variability and agreements were assessed using intraclass correlation coefficients for absolute agreement (ICCa) and consistency (ICCc) as well as Pearson correlation coefficients.ResultsFor FT‐GCS, consistency was excellent comparing different FT vendors (ICCc = 0.84‐0.97, r = 0.86‐0.95) and in comparison to fast SENC (ICCc = 0.78‐0.89, r = 0.73‐0.81). FT‐GCS consistency was excellent compared with tagging (ICCc = 0.79‐0.85, r = 0.74‐0.77) except for TomTec (ICCc = 0.68, r = 0.72). Absolute FT‐GCS agreements among FT vendors were highest for CVI and Medis (ICCa = 0.96) and lowest for TomTec and Neosoft (ICCa = 0.32). Similarly, absolute FT‐GCS agreements were excellent for CVI and Medis compared with both tagging and fast SENC (ICCa = 0.84‐0.88), good to excellent for Neosoft (ICCa = 0.77 and 0.64), and lowest for TomTec (ICCa = 0.41 and 0.47). For FT‐GLS, consistency was excellent (ICCc ≥ 0.86, r ≥ 0.76). Absolute agreements among FT vendors were excellent (ICCa = 0.91‐0.93) or good to excellent for TomTec (ICCa = 0.69‐0.85). Absolute agreements (ICCa) were good (CVI 0.70, Medis 0.60) and fair (TomTec 0.41, Neosoft 0.59) compared with tagging, but excellent compared with fast SENC (ICCa = 0.77‐0.90).ConclusionAlthough absolute agreements differ depending on deformation assessment approaches, consistency and correlation are consistently high regardless of the method chosen, thus indicating reliable strain assessment. Further standardisation and introduction of uniform references is warranted for routine clinical implementation.
Adaptation and validation of the evidence‐based practice beliefs and implementation scales into German
Authors: Kerwien‐Jacquier Emmanuelle , Verloo Henk , Pereira Filipa , Peter Karin Anne 
Published: September 2020

AbstractAimsTo culturally adapt and translate the Evidence‐Based Practice Belief Scale (EBP‐B) and the Evidence‐Based Practice Implementation Scale (EBP‐I), explore the psychometric properties of their validated German versions and compare results with those of the original scales.DesignCross‐sectional descriptive study.MethodThe study was conducted on a sample of 131 Registered Nurses in a Swiss German hospital. Internal consistency was rated using Cronbach's alpha. Principal component analysis using varimax rotation was used to determine construct validity. The study was undertaken in accordance with the STROBE‐checklist in Appendix S1.ResultsGerman versions of the EBP‐B and EBP‐I showed good reliability. Their Cronbach alphas showed lower values than those of the original scales. Principal component analysis showed medium‐to‐high factor loading. Principal component analyses using varimax rotations of the EBP‐B's 16 items and the EBP‐I's 17 items resulted in four‐factor and five‐factor solutions, respectively.
The outcome and cost of a capacity‐building training programme on the early recognition and referral of childhood cancer for healthcare workers in North‐West Cameroon
Authors: Afungchwi Glenn Mbah , Hesseling Peter Bernard , Kouya Francine , Enow Sam A. , Kruger Mariana 
Published: September 2020

AbstractAimEarly cancer diagnosis is necessary to improve survival rates. The aim of this study was to assess the outcome and cost of the childhood cancer training programme amongst healthcare workers.DesignThis was a prospective pre–post study design, using questionnaires for pre‐ and post‐training testing. The warning signs of childhood cancer were used as the main teaching content to improve recognition and early diagnosis.MethodsPre‐training and post‐training knowledge, as well as attitude questionnaires, was administered at the beginning and at the end of each training workshop. Paired samples t test and chi‐square were used to compare the change in knowledge and differences between groups.ResultsThe overall percentage knowledge score increased from 51%–85% (p < .001). The doctors had a better knowledge score than the nurses in the pre‐test (70% versus 50%, p = .008), but there was no significant difference in the post‐test scores. The cost of training was €25.06 per healthcare worker.ConclusionWe recommend similar training programmes in public health to improve early diagnosis of childhood cancer.
Comparing feeling of competence regarding humanistic caring in Belgian nurses and nursing students: A comparative cross‐sectional study conducted in a French Belgian teaching hospital
Authors: Lecocq Dan , Delmas Philippe , Antonini Matteo , Lefebvre Hélène , Laloux Martine , Beghuin Amélie , Van Cutsem Chantal , Bustillo Aurélia , Pirson Magali 
Published: September 2020

AbstractAimThe aim of the study was to describe and compare feeling of competence regarding humanistic caring in Registered Nurses (RN) and nursing students (NS).DesignA quantitative comparative cross‐sectional research design was used.MethodsA convenience sample of 196 RN and 47 NS in a teaching hospital in Belgium completed a self‐administered questionnaire composed of a sociodemographic survey and the Caring Nurse‐Patient Interactions Scale (CNPI‐23) developed by Cossette et al.ResultsThe four dimensions of the CNPI‐23 were compared using the Skillings–Mack test. Both groups scored higher on “humanistic” and “comforting” than on “clinical” and “relational” care and both scored lowest on this last dimension. Linear regressions showed that none of the variables had a statistically significant influence on the CNPI‐23 scores, except for NS “state of health,” which influenced their feeling of competence regarding “relational care.”
Optimal uniform error estimates for moving least‐squares collocation with application to option pricing under jump‐diffusion processes
Authors: Shirzadi Mohammad , Dehghan Mehdi , Bastani Ali Foroush 
Published: September 2020

AbstractIn this study, we derive optimal uniform error bounds for moving least‐squares (MLS) mesh‐free point collocation (also called finite point method) when applied to solve second‐order elliptic partial integro‐differential equations (PIDEs). In the special case of elliptic partial differential equations (PDEs), we show that our estimate improves the results of Cheng and Cheng (Appl. Numer. Math. 58 (2008), no. 6, 884–898) both in terms of the used error norm (here the uniform norm and there the discrete vector norm) and the obtained order of convergence. We then present optimal convergence rate estimates for second‐order elliptic PIDEs. We proceed by some numerical experiments dealing with elliptic PDEs that confirm the obtained theoretical results. The article concludes with numerical approximation of the linear parabolic PIDE arising from European option pricing problem under Merton's and Kou's jump‐diffusion models. The presented computational results (including the computation of option Greeks) and comparisons with other competing approaches suggest that the MLS collocation scheme is an efficient and reliable numerical method to solve elliptic and parabolic PIDEs arising from applied areas such as financial engineering.
A positive cell vertex Godunov scheme for a Beeler–Reuter based model of cardiac electrical activity
Authors: Bendahmane Mostafa , Mroue Fatima , Saad Mazen 
Published: September 2020

AbstractThe monodomain model is a widely used model in electrocardiology to simulate the propagation of electrical potential in the myocardium. In this paper, we investigate a positive nonlinear control volume finite element scheme, based on Godunov's flux approximation of the diffusion term, for the monodomain model coupled to a physiological ionic model (the Beeler–Reuter model) and using an anisotropic diffusion tensor. In this scheme, degrees of freedom are assigned to vertices of a primal triangular mesh, as in conforming finite element methods. The diffusion term which involves an anisotropic tensor is discretized on a dual mesh using the diffusion fluxes provided by the conforming finite element reconstruction on the primal mesh and the other terms are discretized by means of an upwind finite volume method on the dual mesh. The scheme ensures the validity of the discrete maximum principle without any restriction on the transmissibility coefficients. By using a compactness argument, we obtain the convergence of the discrete solution and as a consequence, we get the existence of a weak solution of the original model. Finally, we illustrate by numerical simulations that the proposed scheme successfully removes nonphysical oscillations in the propagation of the wavefront and maintains conduction velocity close to physiological values.
COVID‐19 Impacts Mental Health Outcomes and Ability/Desire to Participate in Research Among Current Research Participants
Authors: Cardel Michelle I. , Manasse Stephanie , Krukowski Rebecca A. , Ross Kathryn , Shakour Rebecca , Miller Darci R. , Lemas Dominick J. , Hong Young‐Rock 
Published: September 2020

ObjectiveThis study aimed to examine the impact of coronavirus disease 2019 (COVID‐19) on current research participants’ mental health outcomes, ability to adhere to behavioral intervention recommendations, and desire to participate in research.MethodsA quantitative/qualitative cross‐sectional survey was used among adults currently enrolled in health‐related research (N = 250; 85% women; > 50% currently enrolled in behavioral weight loss intervention).ResultsCOVID‐19 was perceived as a severe threat by most (62.3%). Related to COVID‐19, 29.6% of participants reported moderate/severe symptoms of anxiety/depression, and 68.4% reported moderate/severe posttraumatic stress disorder (PTSD) symptomatology, with women more likely to demonstrate moderate/severe anxiety/depression (P = 0.047) and PTSD symptomatology (P = 0.028) relative to men. Those with moderate/severe levels of anxiety/depression (P = 0.0154) and distress (P = 0.0330) were more likely to report a decreased desire to participate in research. Among those in behavioral interventions, individuals perceiving COVID‐19 as a moderate/severe threat or experiencing moderate/severe depression or PTSD symptomatology were 4 to 19 times more likely to report that COVID‐19 affected their ability to adhere to behavioral recommendations. Qualitative analysis identified four themes describing COVID‐19's impact on research experiences: transition, remote intervention delivery, ability to adhere to program goals, and research participation interest.ConclusionsThese data suggest that participants engaged in health‐related research perceive COVID‐19 as a significant threat, affecting mental health, desire to participate in research, and ability to adhere to intervention recommendations.
Pointwise‐constrained optimal control of a semiactive vehicle suspension
Authors: Palomares Eduardo , Bellido José C. , Morales Angel L. , Nieto Antonio J. , Chicharro Jose M. , Pintado Publio 
Published: September 2020

SummaryThis article presents an optimal control strategy (OCS) for semiactive vehicle suspensions with road profile sensors. The suspension is modeled as a quarter‐car model with a magnetorheological (MR) damper. The OCS main objective is to minimize the fourth‐power acceleration of the sprung mass. In addition, three pointwise constraints of the model are taken into account when the optimal control problem is solved: suspension travel limits (upper and lower) and tyre vertical force. In order to deal with a large number of constraints, we implement the gradient optimization method based on the method of moving asymptotes routine, which shows very good performance reaching optimal controls while satisfying the constrains. The solution has been compared with two passive MR damper configurations (low and high damping) as well as Skyhook and Balance control strategies for three different road inputs. Results show that OCS fulfills the constraints and reduces the sprung mass acceleration peak and the root‐mean‐quad acceleration up to 59%, in comparison to passive strategies.
CO2 Capture with Silylated Ethanolamines and Piperazines
Authors: Herbig Marcus , Gevorgyan Lia , Pflug Moritz , Wagler Jörg , Schwarzer Sandra , Kroke Edwin 
Published: September 2020

AbstractInvited for this month's cover is the group of Marcus Herbig from the TU Bergakademie in Freiberg. The cover picture shows the reaction of CO2 with a silyl derivative of the biogenic amine ethanolamine. The role of CO2 as a contributor to climate change makes “carbon capture” a desirable goal. However, in addition to simply capture CO2, aminosilanes form silylcarbamates, which represent starting materials for a variety of crucial chemicals. Thus, the entrapped CO2 represents a useful C1 building block. The ESF‐funded Junior Research Group CO2‐Sil at the TU Bergakademie Freiberg (represented by their Logo and location) pursues that kind of goals. CO2‐Sil studies these key reactions of CO2 insertion in depth by syntheses, quantum chemical calculations and calorimetric experiments. CO2 brought to the ground by our method shall be feedstock for various branches in chemistry. Read the full text of their Full Paper at 10.1002/open.201900269.
The two‐ to three‐second time window of shot durations in movies
Authors: Chen Shuai , Cai Mengtong , Bao Yan 
Published: September 2020

AbstractMovie shots of singular scenes have a preferential duration of 2 to 3 s regardless of producers, movie types, and cultural environments. This observation suggests that the temporal structure of movies matches a neural mechanism of information processing in the time domain.
The three second time window in poems and language processing in general: Complementarity of discrete timing and temporal continuity
Authors: Yu Xinchi , Bao Yan 
Published: September 2020

AbstractThe existence of discrete time windows has triggered the search for permanence and continuity for artists (including poets) in multiple cultures throughout history. In this article, we argue that there exists a 3‐s window in the temporal structure of poems as well as in the aesthetic appreciation of poetry by reviewing previous literature on the temporal aspects of poems. This 3‐s window can also be considered to be a general temporal machinery underlying human behavior, including language production and perception in general. The reafference principle has provided us a unique frame for understanding cognitive processes. However, “time” was absent in the original two‐stage reafference principle. Therefore, we propose a three‐stage cycling model of language perception, taking into account time and time windows. We also inspect the possible neural implementations of the three stages: the generation, maintenance, and comparison of predictions (as well as the integration of predictions into the representational context). These three stages are embedded in a temporal window of ~3 s and are repeated in a cycling mode, resulting in the representational context being continuously updated. Thus, it is possible that “semantics” could be carried forward across different time windows, being a “glue” linking the discrete time windows and thus achieving the subjective feeling of temporal continuity. Candidates of such “semantic glue” could include semantic and syntactic structures as well as identity and emotion.