bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-principles study of phase stability, elastic and thermodynamic properties of AlCrFeNi medium-entropy alloys
Authors: Wen Zhiqin , Zou Zhengguang , Zhang Shuchao , Zhao Yuhong 
Published: September 2020

We have applied the first-principles method to predict the phase stability, elastic and thermodynamic properties of ternary (AlCrFe, AlCrNi, CrFeNi and AlFeNi) and quaternary (AlCrFeNi) medium-entropy alloys (MEAs). Both body-centered cubic (BCC) and face-centered cubic (FCC) disordered structures are described using the special quasi-random structures (SQSs) technique. AlCrFe, AlCrNi and AlCrFeNi are favorable in single BCC structures, while CrFeNi is likely to form a single FCC structure. Addition of Ni help stabilizes AlCrFeNi quaternary MEAs. Al and Cr addition are in favor of the formation of BCC AlCrFeNi. Addition of Al, Cr and Ni reduce the resistance to volume deformation for quaternary AlCrFeNi due to the effect of the average number of [Formula: see text]-electrons. The ternary MEAs have better resistance to shear deformation and elastic stiffness than quaternary AlCrFeNi. In addition, all the considered MEAs embody elastic anisotropy and AlCrFeNi are predicted to be ductile behavior. Finally, volumetric thermal expansion coefficient, constant volume heat capacity, vibrational and electronic entropy, and Helmholtz free energies of stable BCC AlCrFeNi, BCC AlCrFe, BCC AlCrNi and FCC CrFeNi are calculated using the Debye–Grüneisen model in temperature ranging from 0 to 1200 K to elucidate the relationships between thermodynamic parameters and temperature.
Searching accurate predicted viscosities near the melting point in a non-strong glass-forming liquid
Authors: Gao Qian , Jian Zengyun , Zhu Man , Chen Yan , Dang Bo , Chang Fange 
Published: September 2020

The accurate predicted viscosities near the melting point [Formula: see text] have been searched. In order to find the temperature ranges, where the measured viscosity data applied to obtain the accurate fitting viscosity data and the accurate fitting expressions near [Formula: see text] lie, the measured data in 15 different temperature ranges (a)–(o) are applied to obtain the fitting viscosity data and the fitting expressions by the Vogel–Fulcher–Tammann (VFT) relation. The accuracy of the fitting viscosity near [Formula: see text] will varies when the measured data in different temperature ranges are applied to obtain the fitting viscosity data by VFT relation. It is found that the accurate fitting viscosity data with the coefficients of determination [Formula: see text] in temperature range 397.3–583.6 K (0.84–1.24[Formula: see text]) near [Formula: see text] can be acquired using the measured data in temperature ranges (g)–(h) and (k) by the VFT relation. In other words, we found the temperature ranges (namely, temperature ranges (g)–(h) and (k)), in which the measured viscosity data applied to obtain the accurate fitting viscosity data and the accurate fitting expressions near [Formula: see text] exist.
Longitudinal vibration wave in the composite elastic metamaterials containing Bragg structure and local resonator
Authors: Lei Xiaofei , Chen Peng , Hou Heping , Liu Shanhui , Liu Peng 
Published: September 2020

In this paper, a novel composite acoustical hyperstructure of Bragg structure with local resonator is investigated theoretically for discussing the scattering performance of longitudinal vibration wave, its bandgaps are calculated using the established mathematical model. For confirming the veritable existence of bandgap and verifying the correctness of established mathematical model, the transmission spectrum of composite acoustical hyperstructure is also studied using finite-element method, and comparing the vibration transmission spectrum with bandgaps, the results indicate that the established theoretical model can correctly predict longitudinal wave bandgaps. Moreover, the bandgaps and modes shapes are calculated and compared with an unalloyed Bragg structure for probing the dispersion mechanics of composite acoustical hyperstructure, it turned out that local resonator can add one bandgap at the base of Bragg structure and the total bandgaps can be broadened. Further, for discussing the effect of spring of local resonator on bandgaps, bandgap of local resonator with different spring is calculated, the results showed that the total width of BG is larger when Young’s modulus is 1E and 16E, the total width are 772.48 and 774.30 Hz, respectively; as Young’s modulus is 0.5E and 2E, the width of BG are lower, 753.79 and 754.23 Hz, respectively. In view of longitudinal vibration wave inducing structural distortion and vibration energy conversion, the dynamic properties of composite acoustical hyperstructure are studied via strain energy density, the results indicate that reaction formation of local resonator can dissipate strain energy, when the local resonator is not activated (or waveless along with Bragg structure), un-dissipation strain energy.
Breast Cancer Cell Detection and Characterization from Breast Milk–Derived Cells
Authors: Bhat-Nakshatri Poornima , Kumar Brijesh , Simpson Ed , Ludwig Kandice K. , Cox Mary L. , Gao Hongyu , Liu Yunlong , Nakshatri Harikrishna 
Published: September 2020

Abstract

Radiologic techniques remain the main method for early detection for breast cancer and are critical to achieve a favorable outcome from cancer. However, more sensitive detection methods to complement radiologic techniques are needed to enhance early detection and treatment strategies. Using our recently established culturing method that allows propagation of normal and cancerous breast epithelial cells of luminal origin, flow cytometry characterization, and genomic sequencing, we show that cancer cells can be detected in breast milk. Cells derived from milk from the breast with cancer were enriched for CD49f+/EpCAM−, CD44+/CD24−, and CD271+ cancer stem–like cells (CSC). These CSCs carried mutations within the cytoplasmic retention domain of HDAC6, stop/gain insertion in MORF4L1, and deletion mutations within SWI/SNF complex component SMARCC2. CSCs were sensitive to HDAC6 inhibitors, BET bromodomain inhibitors, and EZH2 inhibitors, as mutations in SWI/SNF complex components are known to increase sensitivity to these drugs. Among cells derived from breast milk of additional ten women not known to have breast cancer, two of them contained cells that were enriched for the CSC phenotype and carried mutations in NF1 or KMT2D, which are frequently mutated in breast cancer. Breast milk–derived cells with NF1 mutations also carried copy-number variations in CDKN2C, PTEN, and REL genes. The approach described here may enable rapid cancer cell characterization including driver mutation detection and therapeutic screening for pregnancy/postpartum breast cancers. Furthermore, this method can be developed as a surveillance or early detection tool for women at high risk for developing breast cancer.

Significance:
These findings describe how a simple method for characterization of cancer cells in pregnancy and postpartum breast cancer can be exploited as a surveillance tool for women at risk of developing breast cancer.
ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer
Authors: Shah Neel , Kesten Nikolas , Font-Tello Alba , Chang Matthew E.K. , Vadhi Raga , Lim Klothilda , Flory Mark R. , Cejas Paloma , Mohammed Hisham , Long Henry W. , Brown Myles 
Published: September 2020

Abstract

The TMPRSS2-ERG fusion is the most common genomic rearrangement in human prostate cancer. However, in established adenocarcinoma, it is unknown how the ERG oncogene promotes a cancerous phenotype and maintains downstream androgen receptor (AR) signaling pathways. In this study, we utilized a murine prostate organoid system to explore the effects of ERG on tumorigenesis and determined the mechanism underlying prostate cancer dependence on ERG. Prostate organoids lacking PTEN and overexpressing ERG (Pten−/− R26-ERG) faithfully recapitulated distinct stages of prostate cancer disease progression. In this model, deletion of ERG significantly dampened AR-dependent gene expression. While ERG was able to reprogram the AR cistrome in the process of prostate carcinogenesis, ERG knockout in established prostate cancer organoids did not drastically alter AR binding, H3K27ac enhancer, or open chromatin profiles at these reprogrammed sites. Proteomic analysis of DNA-bound AR complexes demonstrated that ERG deletion causes a loss of recruitment of critical AR coregulators and basal transcriptional machinery, including NCOA3 and RNA polymerase II, but does not alter AR binding itself. Together, these data reveal a novel mechanism of ERG oncogene addiction in prostate cancer, whereby ERG facilitates AR signaling by maintaining coregulator complexes at AR bound sites across the genome.

Significance:
These findings exploit murine organoid models to uncover the mechanism of ERG-mediated tumorigenesis and subsequent oncogenic dependencies in prostate cancer.
Chloroquine SensitizesGNAQ/11-mutated Melanoma to MEK1/2 Inhibition
Authors: Truong Amanda , Yoo Jae Hyuk , Scherzer Michael T. , Sanchez John Michael S. , Dale Kali J. , Kinsey Conan G. , Richards Jackson R. , Shin Donghan , Ghazi Phaedra C. , Onken Michael D. , Blumer Kendall J. , Odelberg Shannon J. , McMahon Martin 
Published: September 2020

AbstractPurpose:Mutational activation of GNAQ or GNA11 (GNAQ/11), detected in &gt;90% of uveal melanomas, leads to constitutive activation of oncogenic pathways, including MAPK and YAP. To date, chemo- or pathway-targeted therapies, either alone or in combination, have proven ineffective in the treatment of patients with metastatic uveal melanoma.Experimental Design:We tested the efficacy of chloroquine or hydroxychloroquine, in combination with MAPK pathway inhibition in GNAQ/11-mutated cells in vitro and in vivo and identified mechanisms of MEK1/2 inhibitor plus chloroquine-induced cytotoxicity.Results:Inhibition of GNAQ/11-mediated activation of MAPK signaling resulted in the induction of autophagy. Combined inhibition of Gα and autophagy or lysosome function resulted in enhanced cell death. Moreover, the combination of MEK1/2 inhibition, using trametinib, with the lysosome inhibitor, chloroquine, also increased cytotoxicity. Treatment of mice bearing GNAQ/11-driven melanomas with trametinib plus hydroxychloroquine resulted in inhibition of tumor growth and significantly prolonged survival. Interestingly, lysosomal- and autophagy-specific inhibition with bafilomycin A1 was not sufficient to promote cytotoxicity in combination with trametinib. However, the addition of YAP inhibition with trametinib plus bafilomycin A1 resulted in cell death at comparable levels to trametinib plus chloroquine (T/CQ) treatment. Furthermore, T/CQ-treated cells displayed decreased YAP nuclear localization and decreased YAP transcriptional activity. Expression of a constitutively active YAP5SA mutant conferred resistance to T/CQ-induced cell death.Conclusions:These results suggest that YAP, MEK1/2, and lysosome function are necessary and critical targets for the therapy of GNAQ/11-driven melanoma, and identify trametinib plus hydroxychloroquine as a potential treatment strategy for metastatic uveal melanoma.
Life’s Simple 7 and Incident Hypertension: The REGARDS Study
Authors: Plante Timothy B. , Koh Insu , Judd Suzanne E. , Howard George , Howard Virginia J. , Zakai Neil A. , Booth John N. , Safford Monika M. , Muntner Paul , Cushman Mary 
Published: September 2020

Background
The Life’s Simple 7 (LS7) metric incorporates health behaviors (body mass index, diet, smoking, physical activity) and health factors (blood pressure, cholesterol, glucose) to estimate an individual’s level of cardiovascular health. The association between cardiovascular health and incident hypertension is unresolved. Hypertension’s threshold was recently lowered and it is unclear if better cardiovascular health is associated with lower risk of incident hypertension with the updated threshold or in a multirace cohort. We sought to assess the association between better LS7 score and risk of incident hypertension among Black and White adults using a 130/80 mm Hg hypertension threshold.

Methods and Results
We determined the association between LS7 metric and incident hypertension in the REGARDS (Reasons for Geographic and Racial Disparities in Stroke) study, including participants free of baseline hypertension (2003–2007) who completed a second visit between 2013 and 2016. Hypertension was defined as systolic/diastolic blood pressure ≥130/80 mm Hg or antihypertensive medication use. Each LS7 component was assigned 0 (poor), 1 (intermediate), or 2 (ideal) points. We generated a 14‐point score by summing points. Among 2930 normotensive participants (20% Black, 80% White), the median (25th–75th percentiles) LS7 total score was 9 (8–10) points. Over a median follow‐up of 9 years, 42% developed hypertension. In the fully adjusted model, each 1‐point higher LS7 score had a 6% lower risk of incident hypertension (risk ratio, 0.94 per 1 point; 95% CI, 0.92–0.96).

Conclusions
Better cardiovascular health was associated with lower risk of incident hypertension using a 130/80 mm Hg hypertension threshold among Black and White adults.
The Impact of Outer-Core Surface Heat Fluxes on the Convective Activities and Rapid Intensification of Tropical Cyclones
Authors: Peng Chin-Hsuan , Wu Chun-Chieh 
Published: September 2020

AbstractThe rapid intensification (RI) of Typhoon Soudelor (2015) is simulated using a full-physics model. To investigate how the outer-core surface heat fluxes affect tropical cyclone (TC) structure and RI processes, a series of numerical experiments are performed by suppressing surface heat fluxes between various radii. It is found that a TC would become quite weaker when the surface heat fluxes are suppressed outside the radius of 60 or 90 km [the radius of maximum surface wind in the control experiment (CTRL) at the onset of RI is roughly 60 km]. However, interestingly, the TC would experience stronger RI when the surface heat fluxes are suppressed outside the radius of 150 km. For those sensitivity experiments with capped surface heat fluxes, the members with greater intensification rate show stronger inner-core mid- to upper-level updrafts and higher heating efficiency prior to the RI periods. Although the outer-core surface heat fluxes in these members are suppressed, the inner-core winds become stronger, extracting more ocean energy from the inner core. Greater outer-core low-level stability in these members results in aggregation of deep convection and subsequent generation and concentration of potential vorticity inside the inner core, thus confining the strongest winds therein. The abovementioned findings are also supported by partial-correlation analyses, which reveal the positive correlation between the inner-core convection and subsequent 6-h intensity change, and the competition between the inner-core and outer-core convections (i.e., eyewall and outer rainbands).
A Global, Continental, and Regional Analysis of Changes in Extreme Precipitation
Authors: Sun Qiaohong , Zhang Xuebin , Zwiers Francis , Westra Seth , Alexander Lisa V. 
Published: September 2020

AbstractThis paper provides an updated analysis of observed changes in extreme precipitation using high-quality station data up to 2018. We examine changes in extreme precipitation represented by annual maxima of 1-day (Rx1day) and 5-day (Rx5day) precipitation accumulations at different spatial scales and attempt to address whether the signal in extreme precipitation has strengthened with several years of additional observations. Extreme precipitation has increased at about two-thirds of stations and the percentage of stations with significantly increasing trends is significantly larger than that can be expected by chance for the globe, continents including Asia, Europe, and North America, and regions including central North America, eastern North America, northern Central America, northern Europe, the Russian Far East, eastern central Asia, and East Asia. The percentage of stations with significantly decreasing trends is not different from that expected by chance. Fitting extreme precipitation to generalized extreme value distributions with global mean surface temperature (GMST) as a covariate reaffirms the statistically significant connections between extreme precipitation and temperature. The global median sensitivity, percentage change in extreme precipitation per 1 K increase in GMST is 6.6% (5.1% to 8.2%; 5%–95% confidence interval) for Rx1day and is slightly smaller at 5.7% (5.0% to 8.0%) for Rx5day. The comparison of results based on observations ending in 2018 with those from data ending in 2000–09 shows a consistent median rate of increase, but a larger percentage of stations with statistically significant increasing trends, indicating an increase in the detectability of extreme precipitation intensification, likely due to the use of longer records.
Depth Structure of Ningaloo Niño/Niña Events and Associated Drivers
Authors: Ryan Svenja , Ummenhofer Caroline C. , Gawarkiewicz Glen , Wagner Patrick , Scheinert Markus , Biastoch Arne , Böning Claus W. 
Published: September 2020

AbstractMarine heatwaves along the coast of Western Australia, referred to as Ningaloo Niño, have had dramatic impacts on the ecosystem in the recent decade. A number of local and remote forcing mechanisms have been put forward; however, little is known about the depth structure of such temperature extremes. Utilizing an eddy-active global ocean general circulation model, Ningaloo Niño and the corresponding cold Ningaloo Niña events are investigated between 1958 and 2016, with a focus on their depth structure. The relative roles of buoyancy and wind forcing are inferred from sensitivity experiments. Composites reveal a strong symmetry between cold and warm events in their vertical structure and associated large-scale spatial patterns. Temperature anomalies are largest at the surface, where buoyancy forcing is dominant, and extend down to 300-m depth (or deeper), with wind forcing being the main driver. Large-scale subsurface anomalies arise from a vertical modulation of the thermocline, extending from the western Pacific into the tropical eastern Indian Ocean. The strongest Ningaloo Niños in 2000 and 2011 are unprecedented compound events, where long-lasting high temperatures are accompanied by extreme freshening, which emerges in association with La Niñas, that is more common and persistent during the negative phase of the interdecadal Pacific oscillation. It is shown that Ningaloo Niños during La Niña phases have a distinctively deeper reach and are associated with a strengthening of the Leeuwin Current, while events during El Niño are limited to the surface layer temperatures, likely driven by local atmosphere–ocean feedbacks, without a clear imprint on salinity and velocity.
Weather Radar Network Benefit Model for Nontornadic Thunderstorm Wind Casualty Cost Reduction
Authors: Cho John Y. N. , Kurdzo James M. 
Published: September 2020

AbstractAn econometric geospatial benefit model for nontornadic thunderstorm wind casualty reduction is developed for meteorological radar network planning. Regression analyses on 22 years (1998–2019) of storm event and warning data show, likely for the first time, a clear dependence of nontornadic severe thunderstorm warning performance on radar coverage. Furthermore, nontornadic thunderstorm wind casualty rates are observed to be negatively correlated with better warning performance. In combination, these statistical relationships form the basis of a cost model that can be differenced between radar network configurations to generate geospatial benefit density maps. This model, applied to the current contiguous U.S. weather radar network, yields a benefit estimate of $207 million (M) yr−1 relative to no radar coverage at all. The remaining benefit pool with respect to enhanced radar coverage and scan update rate is about $36M yr−1. Aggregating these nontornadic thunderstorm wind results with estimates from earlier tornado and flash flood cost reduction models yields a total benefit of $1.12 billion yr−1 for the present-day radars and a remaining radar-based benefit pool of $778M yr−1.
A Successful Organized Effort to Improve Operating Room First-Case Starts in a Tertiary Academic Medical Center
Authors: Chua Melissa M. J. , Lewis Keith , Huang Yi-An , Fingliss Mary , Farber Alik 
Published: September 2020

Background Operating room (OR) inefficiency drives up cost, decreases revenue, and leads to surgeon, staff, and patient dissatisfaction. Given a low mean first-case start rate in our tertiary academic medical center, we developed a process to improve first-case start rates in an effort to increase OR efficiency. Methods A working group of the OR Executive Committee was constituted to develop and implement a multistep operational plan. This plan was predicated on a sensible staggered start framework, coordination of stakeholder responsibilities, a visual preoperative Stop/Go checklist tool, real-time measurement, and feedback. Results Within 11 days of implementation, 95% of first-start OR cases were tracked to start on time. Throughout the observation period (May 2015-July 2016), the goal of a daily mean 80% on-time start rate was either met or exceeded. Conclusions Implementation of an organized collaborative effort led to dramatic improvements in first OR case on-time rates. Such improvement in OR utilization may lead to an increase in staff and patient satisfaction and cost reduction.
Association between mode of delivery and postpartum depression: A systematic review and network meta-analysis
Authors: Sun Lei , Wang Su , Li Xi-Qian 
Published: September 2020

Background: Postpartum depression is one of the most common postpartum diseases, which has an important impact on the interaction between mother, infant, partner and family, as well as the long-term emotional and cognitive development of infants. However, there are still great disagreements on whether the delivery mode will affect the risk of postpartum depression. The purpose of this study is to explore whether the mode of delivery will affect the risk of postpartum depression through the comprehensive network meta-analysis of elective cesarean section, emergency cesarean section, instrumental vaginal delivery and spontaneous vaginal delivery. Methods: We searched in three electronic databases: PubMed, EMBASE and Cochrane Library. Results: This paper included 43 studies with a total sample size of 1,827,456 participants. Direct meta-analysis showed that the odds ratio of postpartum depression risk was 1.33 (95% confidence interval = [1.21, 1.46]) between cesarean section and vaginal delivery. The odds ratios of high Edinburgh Postpartum Depression Scale score between cesarean section and vaginal delivery in the three postpartum periods (within 2 weeks, within half a year and over half a year) were basically the same. There was no difference between cesarean section and vaginal delivery in the risk of severe postpartum depression at the Edinburgh Postpartum Depression Scale cut-off point ⩾13 (odds ratio = 1.07; 95% confidence interval = [0.99, 1.16]). Network meta-analysis showed that the risk of postpartum depression in the pairwise comparisons emergency cesarean section vs spontaneous vaginal delivery and elective cesarean section vs spontaneous vaginal delivery was odds ratio = 1.53 (95% confidence interval = [1.22, 1.91]) and 1.47 (95% confidence interval = [1.16, 1.86]). Conclusion: The mode of delivery has a significant effect on the occurrence of mild postpartum depression. Women who give birth by cesarean section, especially who give birth by emergency cesarean section, are at a higher risk of mild postpartum depression. We should carefully monitor the progress of postpartum mental disorders in women who delivered by cesarean section and make it possible for women to have a quick access to mental healthcare.