bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prospectus Regime and Brexit
Authors: Gleeson Simon 
Published: May 2020

Abstract
This chapter discusses the third country regime against the backdrop of Brexit. It explains that, post-Brexit, it will no longer be possible to use a UK prospectus for distribution of securities in the EU. However, since the majorities of securities offered on the UK markets are in fact sold to UK or international (non-EU) investors, it is difficult to know whether the consequence of this will be an increase in EU prospectus offerings or a decrease. The chapter notes that in reality the point is that there is a relatively well-established prospectus orthodoxy in the international securities markets, and as long as the EU regime remains closely aligned with that international orthodoxy, it is likely that the incremental cost of adding an EU limb to a global offering will remain acceptable. However if EU disclosure standards diverge from international standards, the issue will become more acute, and issuers may find themselves having to choose between a domestic EU offering and an international offering.
The Influence of the EU Prospectus Rules on Private Law
Authors: Busch Danny 
Published: May 2020

Abstract
This chapter examines the extent to which the civil courts are bound under EU law by the EU prospectus rules when judging issues of liability. It shows that that the influence of the new EU prospectus rules on private law is potentially considerable, but that the subject is unfortunately surrounded by much uncertainty. EU legislation on prospectus liability would be the best solution, not only for reasons of legal certainty but also for the sake of uniform investor protection and a truly level playing field in Europe. However, in the current political climate, that is likely to be a non-starter for the time being. The chapter concedes that our hopes must therefore be pinned on the Court of Justice of the European Union (CJEU), which will hopefully provide more clarity in the years ahead. But to achieve this the CJEU is dependent on the willingness of national civil courts to submit preliminary rulings with precisely formulated questions that give it sufficient insight into the facts of the case.
Prospectus Liability
Authors: Gargantini Matteo 
Published: May 2020

Abstract
This chapter addresses the European legal framework for cross-border disputes arising from alleged violations of prospectus rules. It deals with the identification of both jurisdiction and applicable law in cases where litigation involves transnational elements, so that a conflict may occur about who is the judge having jurisdiction and what law is this judge bound to apply. Crucial in both respects are, in the first place, the connecting factors to which EU law refers to and, in the second place, the rules concerning issuers' and investors' ability to deviate from such rules. The chapter asserts that the importance of these rules can hardly be overestimated. However, not all courts are equal, and neither are national laws, and the chapter shows these differences affect the topic at hand.
Germany
Authors: Mock Sebastian 
Published: May 2020

Abstract
This chapter discusses German law. In Germany, prospectus liability is a part of the general legal concept of capital market information liability. Although statutory prospectus liability is extensively regulated, prospectus liability is generally of minor importance since cases involving the direct liability of the issuer are rather rare for securities admitted to trading on organised markets. In contrast, the number of cases of prospectus liability for other securities is much higher probably due to the fact that in this part of the capital market more dubious issuers and offerors exist. The rather small number of cases involving securities admitted to trading on organised markets is also due to the fact that German statutory prospectus liability states some major limitations especially regarding the amount of damages the plaintiff can claim. This chapter thus focuses on the prospectus liability for securities traded on organised markets.
Spain
Authors: Campo Javier Redonet Sánchez del 
Published: May 2020

Abstract
This chapter considers the prospectus in Spain. Historically, and unlike other European Union jurisdictions, before the enactment of Directive 2003/71/EC of the European Parliament and of the Council of 4 November 2003 on the prospectus to be published when securities are offered to the public or admitted to trading and amending Directive 2001/34/EC (the ‘Prospectus Directive’), Spain lacked any explicit regulation on the civil liability arising from the defective content of prospectuses for securities offerings and listings in regulated markets. Nevertheless, legal authors having researched on the matter had expressed the view that liability attached to prospectuses on the basis of the general principles of tort liability. The legal regime of prospectus liability enshrined by the Securities Market Act and Royal Decree 1310/2005 is not fully comprehensive, however. In addition, it is completed with the general principles of civil liability contained in the Spanish Civil Code as construed by case law stemming from the Spanish Supreme Court.
United Kingdom
Authors: McMeel Gerard 
Published: May 2020

Abstract
This chapter provides an overview of the relevant UK law. The timing of the coming into force in EU Member States of the Prospectus Regulation posed some problems of exposition of the law in the United Kingdom of liability for information in prospectuses. The date of the Regulation coming into force was when it was originally intended that the UK would leave the European Union. When the date for ‘Brexit’ was extended, the Regulation automatically came into force in accordance with orthodox EU and UK arrangements. However, after changing prime ministers, the date for Brexit became uncertain. Furthermore, there were questions as to whether the UK would leave pursuant to the negotiated Withdrawal Agreement or some other withdrawal agreement, or with no agreement with the EU (the ‘no deal’ scenario) at all. The chapter tries to address the various possible scenarios arising from these complications introduced by Brexit.
Uniformed Services University Medical Student Mentorship Experiences and Gender From 2010 to 2017
Authors: Latham Kerry , Dong Ting , Schreiber Deanna , Torre Dario , Durning Steve , Battista Alexis 
Published: May 2020

Abstract

Introduction
Gender disparity in medicine has drawn increased attention in the form of root cause analysis and programmatic solutions with the goal of equity. Research indicates that mentoring, guidance, and support, which include the provision of social and academic guidance and support from more experienced practitioners, can mitigate challenges associated with gender disparity. The purpose of this study was to explore women medical students’ self-reports of mentorship during their time at Uniformed Services University (USU), if women report similar levels of mentorship as compared to men, and if levels of characteristics associated with mentoring (eg, social support, academic guidance) changed over time.

Materials and Method
Using data from the American Association of Medical College’s Graduate Questionnaire, a survey sent to all medical students prior to graduation, items were coded as related to mentorship, guidance, and support and analyzed to compare responses of female and male students from graduating USU classes of 2010–2017.

Results
No significant difference was found between experiences of female and male survey respondents. Equitable experiences were consistent across time for the 8 years of the study.

Conclusions
Although mentorship is cited as a key factor in mediating gender disparity in medicine, other STEM fields, and the military, the findings suggest that there is equity at the USU undergraduate medical education level. Further studies are needed to understand if disparities in mentorship experiences occur at other stages of a military physician’s career, such as graduate medical education, faculty and academic promotion levels.
A framework for designing and evaluating solar flare forecasting systems
Authors: Cinto T , Gradvohl A L S , Coelho G P , da Silva A E A 
Published: May 2020

ABSTRACT
Disturbances in space weather can negatively affect several fields, including aviation and aerospace, satellites, oil and gas industries, and electrical systems, leading to economic and commercial losses. Solar flares are the most significant events that can affect the Earth’s atmosphere, thus leading researchers to drive efforts on their forecasting. The related literature is comprehensive and holds several systems proposed for flare forecasting. However, most techniques are tailor-made and designed for specific purposes, not allowing researchers to customize them in case of changes in data input or in the prediction algorithm. This paper proposes a framework to design, train, and evaluate flare prediction systems which present promising results. Our proposed framework involves model and feature selection, randomized hyperparameters optimization, data resampling, and evaluation under operational settings. Compared to baseline predictions, our framework generated some proof-of-concept models with positive recalls between 0.70 and 0.75 for forecasting ≥M class flares up to 96 h ahead while keeping the area under the ROC curve score at high levels.
Gravitational burst radiation from pulsars in the Galactic centre and stellar clusters
Authors: Kimpson Tom , Wu Kinwah , Zane Silvia 
Published: May 2020

ABSTRACT
Pulsars (PSRs) orbiting intermediate or supermassive black holes at the centre of galaxies and globular clusters are known as Extreme Mass Ratio Binaries (EMRBs) and have been identified as precision probes of strong-field GR. For appropriate orbital parameters, some of these systems may also emit gravitational radiation in a ‘burst-like’ pattern. The observation of this burst radiation in conjunction with the electromagnetic radio timing signal would allow for multimessenger astronomy in strong-field gravitational regimes. In this work we investigate gravitational radiation from these PSR-EMRBs, calculating the waveforms and SNRs and explore the influence of this GW on the pulsar radio signal. We find that for typical PSR-EMRBs, gravitational burst radiation should be detectable from both the Galactic centre and the centre of stellar clusters, and that this radiation will not meaningfully affect the pulsar timing signal, allowing PSR-EMRB to remain ‘clean’ test-beds of strong-field GR.
Photometry and performance of SPECULOOS-South
Authors: Murray C A , Delrez L , Pedersen P P , Queloz D , Gillon M , Burdanov A , Ducrot E , Garcia L J , Lienhard F , Demory B O , Jehin E , McCormac J , Sebastian D , Sohy S , Thompson S J , Triaud A H M J , Grootel V V , Günther M N , Huang C X 
Published: May 2020

ABSTRACT
SPECULOOS-South, an observatory composed of four independent 1-m robotic telescopes, located at ESO Paranal, Chile, started scientific operation in 2019 January. This Southern hemisphere facility operates as part of the Search for Habitable Planets EClipsing ULtra-cOOl Stars (SPECULOOS), an international network of 1-m-class telescopes surveying for transiting terrestrial planets around the nearest and brightest ultracool dwarfs (UCDs). To automatically and efficiently process the observations of SPECULOOS-South, and to deal with the specialized photometric requirements of UCD targets, we present our automatic pipeline. This pipeline includes an algorithm for automated differential photometry and an extensive correction technique for the effects of telluric water vapour, using ground measurements of the precipitable water vapour. Observing very red targets in the near-infrared can result in photometric systematics in the differential light curves, related to the temporally-varying, wavelength-dependent opacity of the Earth’s atmosphere. These systematics are sufficient to affect the daily quality of the light curves, the longer time-scale variability study of our targets and even mimic transit-like signals. Here we present the implementation and impact of our water vapour correction method. Using the 179 nights and 98 targets observed in the I + z′ filter by SPECULOOS-South since 2019 January, we show the impressive photometric performance of the facility (with a median precision of ∼1.5 mmag for 30-min binning of the raw, non-detrended light curves) and assess its detection potential. We compare simultaneous observations with SPECULOOS-South and TESS, to show that we readily achieve high-precision, space-level photometry for bright, UCDs, highlighting SPECULOOS-South as the first facility of its kind.
A Likelihood Approach for Uncovering Selective Sweep Signatures from Haplotype Data
Authors: Harris Alexandre M , DeGiorgio Michael 
Published: May 2020

AbstractSelective sweeps are frequent and varied signatures in the genomes of natural populations, and detecting them is consequently important in understanding mechanisms of adaptation by natural selection. Following a selective sweep, haplotypic diversity surrounding the site under selection decreases, and this deviation from the background pattern of variation can be applied to identify sweeps. Multiple methods exist to locate selective sweeps in the genome from haplotype data, but none leverages the power of a model-based approach to make their inference. Here, we propose a likelihood ratio test statistic T to probe whole-genome polymorphism data sets for selective sweep signatures. Our framework uses a simple but powerful model of haplotype frequency spectrum distortion to find sweeps and additionally make an inference on the number of presently sweeping haplotypes in a population. We found that the T statistic is suitable for detecting both hard and soft sweeps across a variety of demographic models, selection strengths, and ages of the beneficial allele. Accordingly, we applied the T statistic to variant calls from European and sub-Saharan African human populations, yielding primarily literature-supported candidates, including LCT, RSPH3, and ZNF211 in CEU, SYT1, RGS18, and NNT in YRI, and HLA genes in both populations. We also searched for sweep signatures in Drosophila melanogaster, finding expected candidates at Ace, Uhg1, and Pimet. Finally, we provide open-source software to compute the T statistic and the inferred number of presently sweeping haplotypes from whole-genome data.
Lead-seq: transcriptome-wide structure probing in vivo using lead(II) ions
Authors: Twittenhoff Christian , Brandenburg Vivian B , Righetti Francesco , Nuss Aaron M , Mosig Axel , Dersch Petra , Narberhaus Franz 
Published: May 2020

AbstractThe dynamic conformation of RNA molecules within living cells is key to their function. Recent advances in probing the RNA structurome in vivo, including the use of SHAPE (Selective 2′-Hydroxyl Acylation analyzed by Primer Extension) or kethoxal reagents or DMS (dimethyl sulfate), provided unprecedented insights into the architecture of RNA molecules in the living cell. Here, we report the establishment of lead probing in a global RNA structuromics approach. In order to elucidate the transcriptome-wide RNA landscape in the enteric pathogen Yersinia pseudotuberculosis, we combined lead(II) acetate-mediated cleavage of single-stranded RNA regions with high-throughput sequencing. This new approach, termed ‘Lead-seq’, provides structural information independent of base identity. We show that the method recapitulates secondary structures of tRNAs, RNase P RNA, tmRNA, 16S rRNA and the rpsT 5′-untranslated region, and that it reveals global structural features of mRNAs. The application of Lead-seq to Y. pseudotuberculosis cells grown at two different temperatures unveiled the first temperature-responsive in vivo RNA structurome of a bacterial pathogen. The translation of candidate genes derived from this approach was confirmed to be temperature regulated. Overall, this study establishes Lead-seq as complementary approach to interrogate intracellular RNA structures on a global scale.
PseudoChecker: an integrated online platform for gene inactivation inference
Authors: Alves Luís Q , Ruivo Raquel , Fonseca Miguel M , Lopes-Marques Mónica , Ribeiro Pedro , Castro L Filipe C 
Published: May 2020

Abstract
The rapid expansion of high-quality genome assemblies, exemplified by ongoing initiatives such as the Genome-10K and i5k, demands novel automated methods to approach comparative genomics. Of these, the study of inactivating mutations in the coding region of genes, or pseudogenization, as a source of evolutionary novelty is mostly overlooked. Thus, to address such evolutionary/genomic events, a systematic, accurate and computationally automated approach is required. Here, we present PseudoChecker, the first integrated online platform for gene inactivation inference. Unlike the few existing methods, our comparative genomics-based approach displays full automation, a built-in graphical user interface and a novel index, PseudoIndex, for an empirical evaluation of the gene coding status. As a multi-platform online service, PseudoChecker simplifies access and usability, allowing a fast identification of disruptive mutations. An analysis of 30 genes previously reported to be eroded in mammals, and 30 viable genes from the same lineages, demonstrated that PseudoChecker was able to correctly infer 97% of loss events and 95% of functional genes, confirming its reliability. PseudoChecker is freely available, without login required, at http://pseudochecker.ciimar.up.pt.
SYNERGxDB: an integrative pharmacogenomic portal to identify synergistic drug combinations for precision oncology
Authors: Seo Heewon , Tkachuk Denis , Ho Chantal , Mammoliti Anthony , Rezaie Aria , Madani Tonekaboni Seyed Ali , Haibe-Kains Benjamin 
Published: May 2020

Abstract
Drug-combination data portals have recently been introduced to mine huge amounts of pharmacological data with the aim of improving current chemotherapy strategies. However, these portals have only been investigated for isolated datasets, and molecular profiles of cancer cell lines are lacking. Here we developed a cloud-based pharmacogenomics portal called SYNERGxDB (http://SYNERGxDB.ca/) that integrates multiple high-throughput drug-combination studies with molecular and pharmacological profiles of a large panel of cancer cell lines. This portal enables the identification of synergistic drug combinations through harmonization and unified computational analysis. We integrated nine of the largest drug combination datasets from both academic groups and pharmaceutical companies, resulting in 22 507 unique drug combinations (1977 unique compounds) screened against 151 cancer cell lines. This data compendium includes metabolomics, gene expression, copy number and mutation profiles of the cancer cell lines. In addition, SYNERGxDB provides analytical tools to discover effective therapeutic combinations and predictive biomarkers across cancer, including specific types. Combining molecular and pharmacological profiles, we systematically explored the large space of univariate predictors of drug synergism. SYNERGxDB constitutes a comprehensive resource that opens new avenues of research for exploring the mechanism of action for drug synergy with the potential of identifying new treatment strategies for cancer patients.
Adult immuno-oncology: using past failures to inform the future
Authors: Rahman Maryam , Sawyer W Gregory , Lindhorst Scott , Deleyrolle Loic P , Harrison Jeffrey K , Karachi Aida , Dastmalchi Farhad , Flores-Toro Joseph , Mitchell Duane A , Lim Michael , Gilbert Mark R , Reardon David A 
Published: May 2020

AbstractIn oncology, “immunotherapy” is a broad term encompassing multiple means of utilizing the patient’s immune system to combat malignancy. Prominent among these are immune checkpoint inhibitors, cellular therapies including chimeric antigen receptor T-cell therapy, vaccines, and oncolytic viruses. Immunotherapy for glioblastoma (GBM) has had mixed results in early trials. In this context, the past, present, and future of immune oncology for the treatment of GBM was discussed by clinical, research, and thought leaders as well as patient advocates at the first annual Remission Summit in 2019. The goal was to use current knowledge (published and unpublished) to identify possible causes of treatment failures and the best strategies to advance immunotherapy as a treatment modality for patients with GBM. The discussion focuses on past failures, current limitations, failure analyses, and proposed best practices moving forward.
Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation
Authors: Turnquist Casmir , Harris Brent T , Harris Curtis C 
Published: May 2020

AbstractContinued improvements in cancer therapies have increased the number of long-term cancer survivors. Radiation therapy remains one of the primary treatment modalities with about 60% of newly diagnosed cancer patients receiving radiation during the course of their disease. While radiation therapy has dramatically improved patient survival in a number of cancer types, the late effects remain a significant factor affecting the quality of life particularly in pediatric patients. Radiation-induced brain injury can result in cognitive dysfunction, including hippocampal-related learning and memory dysfunction that can escalate to dementia. In this article, we review the current understanding of the mechanisms behind radiation-induced brain injury focusing on the role of neuroinflammation and reduced hippocampal neurogenesis. Approaches to prevent or ameliorate treatment-induced side effects are also discussed along with remaining challenges in the field.
Urinary Cyanoethyl Mercapturic Acid, a Biomarker of the Smoke Toxicant Acrylonitrile, Clearly Distinguishes Smokers From Nonsmokers
Authors: Luo Xianghua , Carmella Steven G , Chen Menglan , Jensen Joni A , Wilkens Lynne R , Le Marchand Loic , Hatsukami Dorothy K , Murphy Sharon E , Hecht Stephen S 
Published: May 2020

Abstract

Introduction
Cyanoethyl mercapturic acid (CEMA) is a urinary metabolite of acrylonitrile, a toxicant found in substantial quantities in cigarette smoke, but not in non-combusted products such as e-cigarettes or smokeless tobacco and rarely in the diet or in the general human environment. Thus, we hypothesized that CEMA is an excellent biomarker of combusted tobacco product use.

Aims and Methods
We tested this hypothesis by analyzing CEMA in the urine of 1259 cigarette smokers (urinary cotinine ≥25 ng/mL) and 1191 nonsmokers. The analyses of CEMA and cotinine were performed by validated liquid chromatography–tandem mass spectrometry methods. Logistic regression was fit for log-transformed CEMA to construct the receiver operating characteristic curve.

Results
We found that a CEMA cutpoint of 27 pmol/mL urine differentiated cigarette smokers from nonsmokers with sensitivity and specificity greater than 99%. The use of different cotinine cutpoints to define smokers (10–30 ng/mL) had little effect on the results.

Conclusions
CEMA is a highly reliable urinary biomarker to identify users of combusted tobacco products such as cigarettes as opposed to users of non-combusted products, medicinal nicotine, or nonusers of tobacco products.

Implications
CEMA can be used to distinguish users of combusted tobacco products from non-combusted products such as e-cigarettes, smokeless tobacco, and medicinal nicotine. Levels of CEMA in the urine of people who use these non-combusted products are extremely low, in contrast to cotinine.