bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontal treatment, psychological factors and oral health‐related quality of life
Authors: Rawlinson Andrew , Vettore Mario V. , Baker Sarah R , Robinson Peter G 
Published: December 2020

AbstractAimsTo determine changes in OHRQoL and clinical status after periodontal treatment and the factors predicting these changes.MethodsCohort of 140 patients with chronic periodontitis receiving non‐surgical treatment. Participant self‐completed questionnaires: Sense of Coherence, Locus of Control, Self‐esteem and Task‐specific Self‐efficacy before treatment, and Oral Health Impact Profile at treatment, oral hygiene review and end of study. Relationships between OHRQoL, clinical data, individual and environmental characteristics were analysed with structural equation modelling guided by the Wilson and Cleary model.ResultsOHRQoL and the periodontal status improved after treatment. Greater sense of coherence and age, better periodontal status, lower DMFT and being male predicted better OHRQoL after treatment. Better task‐specific self‐efficacy and self‐esteem, but worse plaque score predicted better end periodontal status.ConclusionsOHRQoL and periodontal status improved after periodontal treatment, and this was predicted by individual demographic and psychological factors. These factors may assist with case selection and as possible points for intervention to improve clinical and subjective outcomes of periodontal treatment.
Thermo-Mechanical Fatigue Crack Growth Testing
Authors: Borg Jennifer , Platts Norman , Gill Peter , Mann Jonathan , Currie Chris 
Published: December 2020

Abstract
Laboratory data have indicated that light water reactor environments can significantly reduce the fatigue life and crack growth performance of austenitic stainless steels. These environmental effects have been codified into design procedures and documents such as NUREG/CR-6909 Rev 1 (fatigue life) and ASME code case N-809 (crack growth). However, there is considered to be significant conservatism in these methods when applied to plant relevant loadings.
The Weighted K-Rate, WKR, method was initially developed by J. Emslie et.al (PVP2016-63497) to address the influence of waveform shape as one of the potential sources of the over-conservatism in code case N-809. This method was found to significantly reduce the over-conservatism associated with ASME code case N-809. However, this method was based solely on isothermal data, and was shown to also retain significant over-conservatism, especially for out-of-phase non-isothermal waveforms typical of many thermally induced loading transients. The WKR method was further evolved into the Weighted Temperature and K-rate (WTKR) method, by Currie et.al (PVP2019-93855), further updated by Mann et.al (PVP2020-21585), which partitions the damage across the loading cycle, under non-isothermal conditions, and has been shown to significantly reduce the perceived over-conservatism associated with ASME code case N-809 when applied to many plant-relevant loading waveforms. This paper describes work that was done to investigate the impact of non-isothermal temperature / loading waveforms, and forms the bulk of non-isothermal data from which the WTKR method was derived.
The data presented in this paper indicate that for out-of-phase transient loading (typical of most thermally induced plant loadings), and simple isothermal loading at low temperatures and longer rise times, the WTKR method provides a more accurate prediction of fatigue crack growth rates than the application of ASME code case N-809.
Mode I Ductile Crack Growth of 1TC(T) Specimen Under Large Cyclic Loading: Part IV
Authors: Hojo Kiminobu 
Published: December 2020

Abstract
Ductile crack growth calculation method under excessive cyclic loading in a fitness for service rule has not been established even in Mode I. Since 2017 to 2019 the author had tried to establish how to determine the parameters of the combined hardening rule and applied it to simulate the ductile crack growth behavior of the 1TC(T) specimens of the different loading levels for ferritic steel. Also ΔJ calculation using the reference stress method, and the transferred crack growth rate from a code were applied to estimate the ductile crack growth. Several equations of the reference stress method were tried to apply in the previous paper. Further the prediction procedure using the ΔJ, the reference stress method and da/dN-ΔJ curve based on the JSME rules on fitness for service (FFS) was applied to the pipe fracture tests under cyclic loading and its applicability was discussed for the case of a pipe structure in the previous paper. In this paper similar procedures were applied to 1TC(T) specimens of stainless steel. The combined hardening rule was applied for the constitution law of stress-strain curve. The numerical simulation with the combined rule traced the load-load line displacement curve under the cyclic loading experiments of 1TC(T). Also austenitic stainless fatigue crack growth rate (FCGR) in air condition from the JSME rules on FFS bounded the experimental crack growth rate, which means the FCGR of the JSME rules is applicable to fatigue crack growth calculation.
Magma plumbing system and origin of the intraplate volcanoes in Mainland China: an overview of constraints from geophysical imaging
Authors: Yu Weiqian , Wei Wei , Wei Feixiang , Bai Xiang , Liu Songjun , Xu Dan 
Published: December 2020

Abstract
Volcanic eruptions, despite causing large-scale disasters, also provide important natural resources and are an effective way to understand the Earth's internal structure and its evolution. Herein, a comprehensive review is presented on recent progress in geophysical imaging of the structure and origin of intraplate volcanoes in Mainland China. We primarily focus on the Changbaishan, Wudalianchi, Tengchong, Hainan and Ashikule volcanoes as they are currently active and hence pose potential hazards during future eruptions, particularly the Changbaishan volcano. The Changbaishan and Wudalianchi volcanoes are widely believed to be caused by the dehydration of the stagnant Pacific slab in the mantle transition zone along with wet upwelling in the big mantle wedge. There are a number of different views regarding the formation mechanism of the Tengchong volcano. Some studies suggest that a big mantle wedge structure is also present under eastern Tibet, and the Tengchong volcano has a deep origin, similar to volcanism in NE China. Others suggest that the Tengchong volcano is caused by a local and shallow process. Most tomographic studies suggest that the Hainan volcano is a hotspot, and its track has been located in SE China by combining seismological, geochemical and numerical modelling data. A gap exists between the subducted Indian Plate and the Tarim lithosphere beneath the Ashikule volcano, which provides a channel for asthenospheric upwelling to give rise to intraplate volcanism in the Ashikule basin. The interactions of lithospheres may produce shear heating of the subcontinental lithospheric mantle, which can generate localized melting. This process has been proposed as an explanation for the intraplate volcanism in Ashikule.
Latent Class Trajectory Modeling of Adult Body Mass Index and Risk of Obesity-Related Cancer: Findings from the Melbourne Collaborative Cohort Study
Authors: Yang Yi , Lynch Brigid M. , Dugué Pierre-Antoine , Karahalios Amalia , MacInnis Robert J. , Bassett Julie K. , McAleese Alison , Sinclair Craig , Giles Graham G. , Milne Roger L. , Hodge Allison M. , English Dallas R. 
Published: December 2020

Abstract

Background:
Obesity increases the risk of 13 cancer types. Given the long process of carcinogenesis, it is important to determine the impact of patterns of body mass over time.

Methods:
Using data from 30,377 participants in the Melbourne Collaborative Cohort Study, we identified body mass index (BMI) trajectories across adulthood and examined their association with the risk of obesity-related cancer. Participants completed interviews and questionnaires at baseline (1990–1994, age 40–69 years), follow-up 1 (1995–1998), and follow-up 2 (2003–2005). Body mass was recalled for age 18 to 21 years, measured at baseline, self-reported at follow-up 1, and measured at follow-up 2. Height was measured at baseline. Cancer diagnoses were ascertained from the Victorian Cancer Registry and the Australian Cancer Database. A latent class trajectory model was used to identify BMI trajectories that were not defined a priori. Cox regression was used to estimate HRs and 95% confidence intervals (CI) of obesity-related cancer risks by BMI trajectory.

Results:
Six distinct BMI trajectories were identified. Compared with people who maintained lower normal BMI, higher risks of developing obesity-related cancer were observed for participants who transitioned from normal to overweight (HR, 1.29; 95% CI, 1.13–1.47), normal to class I obesity (HR, 1.50; 95% CI, 1.28–1.75), or from overweight to class II obesity (HR, 1.66; 95% CI, 1.32–2.08).

Conclusions:
Our findings suggest that maintaining a healthy BMI across the adult lifespan is important for cancer prevention.

Impact:
Categorization of BMI by trajectory allowed us to identify specific risk groups to target with public health interventions.
Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo
Authors: Li Peng , He Yunjiao , Chen Teng , Choy Kit-Ying , Chow Tsun Sing , Wong Iris L.K. , Yang Xinqing , Sun Wenqin , Su Xiaochun , Chan Tak-Hang , Chow Larry M.C. 
Published: December 2020

Abstract
Staphylococcal nuclease domain-containing protein 1 (SND1) is a multifunctional oncoprotein overexpressed in breast cancer. Binding of metadherin (MTDH) to SND1 results in the stabilization of SND1 and is important in the initiation and progression of breast cancer. Disruption of such interaction is a potential therapeutic for breast cancer. SN1/2 domain of SND1 was used as bait in a phage display screening to identify a 12-amino acid peptide 4-2. The activity of peptide 4-2 was evaluated by ELISA, coimmunoprecipitation, MTS, Western blot analysis, and xenograft mouse model. Peptide 4-2 could disrupt SND1–MTDH interaction. Cell penetrating derivative of peptide 4–2 (CPP-4–2) could penetrate and kill breast cancer cells by disrupting SND1–MTDH interaction and degrading SND1. Tryptophan 10 (W10) of peptide 4-2 was essential in mediating cytotoxicity, SND1 interaction, SND1–MTDH disruption, and SND1 degradation. CPP-4-2 could inhibit the growth of breast cancer in a xenograft mouse model. The SND1-interacting peptide 4-2 could kill breast cancer cells both in vitro and in vivo by interacting with SND1, disrupting SND1–MTDH interaction, and inducing SND1 degradation. W10 was an essential amino acid in the activity of peptide 4-2.
Valve-in-Valve and Valve-in-Ring Transcatheter Mitral Valve Implantation in Young Women Contemplating Pregnancy
Authors: Fuchs Adeline , Urena Marina , Chong-Nguyen Caroline , Kikoïne John , Brochet Eric , Abtan Jérémie , Fischer Quentin , Ducrocq Grégory , Vahanian Alec , Iung Bernard , Himbert Dominique 
Published: December 2020

Background:
Transcatheter mitral valve implantation (TMVI) is emerging as an alternative to surgical mitral valve replacement in selected high-risk patients. Delaying definitive mechanical mitral valve replacement and the constraints of anticoagulation thanks to TMVI may be an attractive option in young women contemplating pregnancy and suffering from failure of mitral bioprosthesis or annuloplasty. The aim of the study was to evaluate the possibility, safety, and outcomes of pregnancy after TMVI in this population.

Methods:
From 2013 to 2019, 12 young women contemplating pregnancy underwent transseptal valve-in-valve or valve-in-ring TMVI using the Edwards SAPIEN XT/3 valves and were prospectively followed up at 1 month, 6 months, 1 year, and yearly thereafter.

Results:
Mean age of the patients was 30±6 years. Bioprosthesis degeneration was observed in 7 cases and annuloplasty failure in 5. Three valve-in-ring patients required the implantation of a second valve, which led to an overall procedural success rate of 75%. One delayed left ventricular outflow tract obstruction required elective surgical mitral valve replacement. At 6 months/1 year, 83% of the patients were in New York Heart Association classes I/II. Mitral regurgitation was ≤2+ in all the cases and mean gradient was 7±2 mm Hg. Four patients could complete 6 full-term pregnancies. One symptomatic thrombosis occurred and resolved under aspirin and anticoagulation therapy. All others pregnancies were uneventful. Predelivery mean gradient was 11 mm Hg, and systolic pulmonary artery pressure was 32 mm Hg. There were 4 vaginal deliveries and 2 cesarians. Newborns were alive and healthy. At last follow-up, there was no death, and 3 patients required elective surgical mitral valve replacement at 6- to 54-month follow-up.

Conclusions:
Our study suggests that, in young women, transseptal TMVI to treat failing bioprostheses may result in good short-term outcomes that allow uneventful pregnancies. The results are less favorable in women with failed annuloplasty rings.
Outcome of clinical and subclinical myocardial injury in systemic lupus erythematosus – A prospective cohort study
Authors: du Toit Riette , Herbst Phillip G , Ackerman Christelle , Pecoraro Alfonso JK , Claassen Dirk , Cyster Henry P , Reuter Helmuth , Doubell Anton F 
Published: December 2020

Objectives To determine the outcome of subclinical lupus myocarditis (LM) over twelve months with regards to: mortality; incidence of clinical LM and change in imaging parameters (echocardiography and cardiac magnetic resonance [CMR]). To evaluate the impact of immunosuppression on CMR evidence of myocardial tissue injury. Methods SLE patients with and without CMR evidence of myocardial injury (as per 2009 Lake Louise criteria [LLC]) were included. Analysis at baseline and follow-up included: clinical evaluation, laboratory and imaging analyses (echocardiography and CMR). Clinical LM was defined as clinical features of LM supported by echocardiographic and/or biochemical evidence of myocardial dysfunction. Subclinical LM was defined as CMR myocardial injury without clinical LM. Results Forty-nine SLE patients were included with follow-up analyses (after 12 months) available in 36 patients. Twenty-five patients (51%) received intensified immunosuppressive therapy during follow-up for indications related to SLE. Disease activity (SLEDAI-2K) improved (p < 0.001) from 13 (median;IQR:9–20) to 7 (3–11). One patient without initial CMR evidence of myocardial injury developed clinical LM. Mortality (n = 10) and SLE clinical features were similar between patients with and without initial CMR myocardial injury. Echocardiographic left ventricular ejection fraction (LVEF) (p = 0.014), right ventricular function (p = 0.001) and wall motion abnormalities (p = 0.056) improved significantly but not strain analyses nor the left LV internal diameter index. CMR mass index (p = 0.011) and LVEF (p < 0.001) improved with follow-up but not parameters identifying myocardial tissue injury (LLC). A trend towards a reduction in the presence of CMR criteria was counterbalanced by persistence (n = 7) /development of new criteria (n = 11) in patients. Change in CMR mass index correlated with change in T2-weighted signal (myocardial oedema) (r = 386;p = 0.024). Intensified immunosuppressive therapy had no significant effect on CMR parameters. Conclusion CMR evidence of subclinical LM persisted despite improved SLEDAI-2K, serological markers, cardiac function and CMR mass index. Subclinical LM did not progress to clinical LM and had no significant prognostic implications over 12 months. Immunosuppressive therapy did not have any significant effect on the presence of CMR evidence of myocardial tissue injury. Improvement in CMR mass index correlated with reduction in myocardial oedema and may be used to monitor SLE myocardial injury.
Repurposing From Oncology to Cardiology: Low-Dose 5-Azacytidine Attenuates Pathological Cardiac Remodeling in Response to Pressure Overload Injury
Authors: Russell-Hallinan Adam , Neary Roisin , Watson Chris J. , Baugh John A. 
Published: December 2020

Introduction: Recent evidence suggests that transcriptional reprogramming is involved in the pathogenesis of cardiac remodeling (cardiomyocyte hypertrophy and fibrosis) and the development of heart failure. 5-Azacytidine (5aza), an inhibitor of DNA methylation approved for hematological malignancies, has previously demonstrated beneficial effects on cardiac remodeling in hypertension. The aim of our work was to investigate whether pressure overload is associated with alterations in DNA methylation and if intervention with low-dose 5aza can attenuate the associated pathological changes. Methods and Results: C57Bl6/J mice underwent surgical constriction of the aortic arch for 8 weeks. Mice began treatment 4 weeks post-surgery with either vehicle or 5aza (5 mg/kg). Cardiac structure and function was examined in vivo using echocardiography followed by post mortem histological assessment of hypertrophy and fibrosis. Global DNA methylation was examined by immunostaining for 5-methylcytosine (5MeC) and assessment of DNA methyltransferase expression. The results highlighted that pressure overload-induced pathological cardiac remodeling is associated with increased DNA methylation (elevated cardiac 5MeC positivity and Dnmt1 expression). Administration of 5aza attenuated pathological remodeling and diastolic dysfunction. These beneficial changes were mirrored by a treatment-related reduction in global 5MeC levels and expression of Dnmt1 and Dnmt3B in the heart. Conclusion: DNA methylation plays an important role in the pathogenesis of pressure overload-induced cardiac remodeling. Therapeutic intervention with 5aza, at a dose 5 times lower than clinically given for oncology treatment, attenuated myocardial hypertrophy and fibrosis. Our work supports the rationale for its potential use in cardiac pathologies associated with aberrant cardiac wound healing.
Core decompression with bone chips allograft in combination with fibrin platelet-rich plasma and concentrated autologous mesenchymal stromal cells, isolated from bone marrow: results for the treatment of avascular necrosis of the femoral head after 2 years minimum follow-up
Authors: Rocchi Martina , Del Piccolo Nicoladrea , Mazzotta Alessandro , Giavaresi Gianluca , Fini Milena , Facchini Fabio , Stagni Cesare , Dallari Dante 
Published: December 2020

Introduction: Avascular necrosis of femoral head (AVN) is 1 of the main factors causing disability in young adults. Hip prosthesis can be considered an effective treatment of the painful symptoms but it is a major surgical intervention for this type of population. Thus, a large space should be left to therapeutic alternatives such as regenerative medicine. This retrospective study evaluates 52 AVN treated by core decompression, bone chips allograft, fibrin platelet-rich plasma (PRF) and concentrated autologous mesenchymal stromal cells (MSCs). Methods: The AVN was diagnosed using magnetic resonance imaging (MRI) and graded according to ARCO classification: a patient was classified stage 1 (21 patients), stage 3 (26 patients), and 4 patients were classified as stage 4. We evaluated patients with functional scores (Harris Hip Score) and radiological analysis at 3, 6, 12 and 24 months after the procedure. Patients requiring prosthetic replacement of the joint were included; in these cases, follow-up was interrupted at the time of the joint replacement procedure. Results: Our statistical analysis showed differences between survived and failed treatments, in terms of patient profile and ARCO radiological classification. The best result occurred in patients with ARCO grades 1 and 2, while the more advanced grades showed a high failure rate. It is interesting to note that ARCO quantification, conceived as the joint surface involved in the necrosis, has a negative influence on the outcome of the procedure. Indeed, patients affected by ARCO 3a, where necrosis involved a small portion of the femoral epiphysis and the collapse of the articular surface was limited to 2 mm, showed results similar to those obtained in patients with ARCO 1 and 2. Conclusions: In conclusion, compared with the alternative technique of decompression, our data suggest that post-collapse cases with a small area of necrosis and the use of bone grafts may show better results compared to those of the literature.
“Anterolateral” approach to the hip: a systematic review of the correct definition of terms
Authors: Lepri Andrea Cozzi , Villano Marco , Matassi Fabrizio , Carulli Christian , Innocenti Massimo , Civinini Roberto 
Published: December 2020

Purpose: The Watson-Jones interval plane between tensor fascia lata (TFL) and the gluteus medius (GM) has come back into fashion in the past few years - Röttinger described the anterolateral minimal invasive approach (ALMI) for use in total hip replacement, in which the standard Watson-Jones interval was used, but with a completely intermuscular plane. However, the term anterolateral is often still utilised to describe intramuscular approaches in which the GM was violated, thus creating a potential misunderstanding in the literature. Accordingly, we have designed a study to answer the following questions: (1) are there articles in the recent literature that use the term “anterolateral” to describe different approaches; (2) which would be the correct description of the anterolateral approach? Methods: We did a systematic review of the literature based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, to look for peer reviewed papers of any evidence level focusing on the definition of anterolateral approach; MEDLINE and EMBASE were searched. Results: 73 manuscripts met the criteria of the systematic search. 53 papers (72.6%) reported the term anterolateral approach to describe a complete intermuscular approach between the interval between GM and TFL. Nonetheless, in the remaining 20 papers (27.4%) the term anterolateral was used to describe intramuscular approaches in which the gluteus medius was violated. Conclusion: In about 1 out of 4 papers in the recent literature, the term anterolateral was utilised to describe approaches that are completely different both in terms of anatomy and function.