bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity of Tumor Necrosis Factor Antagonists and Effect of Dose Escalation on Anti-Drug Antibodies and Serum Drug Concentrations in Inflammatory Bowel Disease
Authors: Battat Robert , Lukin Dana , Scherl Ellen J , Pola Suresh , Kumar Anand , Okada Lauren , Yang Lei , Jain Anjali , Siegel Corey A 
Published: December 2020

Abstract

Background
Infliximab and adalimumab concentrations are associated with important outcomes in inflammatory bowel disease (IBD). Antibodies to infliximab (ATI) and adalimumab (ATA) are associated with reduced drug concentrations and worse outcomes. Because the efficacy of dose escalation to overcome antibodies is unclear, we assessed the impact of this strategy to overcome immunogenicity in IBD.

Methods
Infliximab and adalimumab dosing, drug, and antibody concentrations were extracted from a database of patients with IBD having specimens collected for therapeutic drug monitoring. The primary outcome compared proportions with either infliximab ≥5 μg/mL or adalimumab ≥7.5 μg/mL and undetectable antibodies between dose-escalated and non-escalated patients. Area under the receiver operating characteristic curve analyses determined antibody concentrations below which dose escalation was associated with the primary outcome.

Results
The study included 63,176 patients treated with infliximab and 46,429 patients treated with adalimumab. We detected ATI and ATA in 23.6% (n = 14,900) of patients treated with infliximab and 19.6% (n = 9101) of patients treated with adalimumab. In patients with ATI, infliximab dose escalation (n = 453) yielded higher proportions achieving the primary outcome (47.5% vs 30.9%; P &lt; 0.001), greater drug concentration increases (5.9 μg/mL vs 0.2 μg/mL; P &lt; 0.001), and ATI reductions (4.3 U/mL vs 1.9 U/mL; P = 0.002) compared to no escalation (n = 204). An ATI threshold of 8.55 U/mL was associated with achieving the primary outcome with dose escalation (area under the curve = 0.66). For patients with ATI ≤8.55 U/mL (n = 274), higher proportions (59.1% vs 29.6%; P &lt; 0.001) achieved the primary outcome compared with those with ATI &gt;8.55 U/mL (n = 179). No patients treated with adalimumab achieved the primary outcome (0/390), regardless of dose escalation (n = 87).

Conclusion
Dose escalation increased drug concentrations and eliminated antibodies with infliximab but not adalimumab. Initial ATI ≤8.55 U/mL was associated with increased efficacy of dose escalation using this assay.
The information complexity of learning tasks, their structure and their distance
Authors: Achille Alessandro , Paolini Giovanni , Mbeng Glen , Soatto Stefano 
Published: December 2020

Abstract
We introduce an asymmetric distance in the space of learning tasks and a framework to compute their complexity. These concepts are foundational for the practice of transfer learning, whereby a parametric model is pre-trained for a task, and then fine tuned for another. The framework we develop is non-asymptotic, captures the finite nature of the training dataset and allows distinguishing learning from memorization. It encompasses, as special cases, classical notions from Kolmogorov complexity and Shannon and Fisher information. However, unlike some of those frameworks, it can be applied to large-scale models and real-world datasets. Our framework is the first to measure complexity in a way that accounts for the effect of the optimization scheme, which is critical in deep learning.
The generalized orthogonal Procrustes problem in the high noise regime
Authors: Pumir Thomas , Singer Amit , Boumal Nicolas 
Published: December 2020

AbstractWe consider the problem of estimating a cloud of points from numerous noisy observations of that cloud after unknown rotations and possibly reflections. This is an instance of the general problem of estimation under group action, originally inspired by applications in three-dimensional imaging and computer vision. We focus on a regime where the noise level is larger than the magnitude of the signal, so much so that the rotations cannot be estimated reliably. We propose a simple and efficient procedure based on invariant polynomials (effectively: the Gram matrices) to recover the signal, and we assess it against fundamental limits of the problem that we derive. We show our approach adapts to the noise level and is statistically optimal (up to constants) for both the low and high noise regimes. In studying the variance of our estimator, we encounter the question of the sensivity of a type of thin Cholesky factorization, for which we provide an improved bound which may be of independent interest.
Making Geoeconomics an IR Research Program
Authors: Kim Dong Jung 
Published: December 2020

AbstractIn contrast to growing public attention to geoeconomics as the new mode of conducting great power competition, the IR discipline has not actively engaged in conceptual and theoretical analysis from the geoeconomic viewpoint. This article examines issues that geoeconomics needs to solve to become a new theoretical framework in the positivist “American” IR scholarship that dominates research on great power competition. On the one hand, the concept of geoeconomics needs to be redefined and account for a phenomenon that is not already covered in extant IR scholarship. Thus, geoeconomics should be considered as a form of grand strategy and defined as the use of economic instruments to advance mid- to long-term strategic interests in a geographical region of the world. On the other hand, geoeconomics in positivist IR should take into account international economic structure and domestic politics in developing a parsimonious explanation for the conditions to employ geoeconomic grand strategy. In this process, the theorist needs to make an analytical choice to concentrate on certain factors and mechanisms to assure theoretical parsimony. This article concludes that addressing the issues of conceptual clarity and parsimonious theorization would potentially allow geoeconomics to become a new research program in positivist IR.
The Financial Consequences of Rating International Institutions: Competition, Collaboration, and the Politics of Assessment
Authors: Lall Ranjit 
Published: December 2020

AbstractThe past 15 years have witnessed a striking trend in global governance: the creation of comparative indicators of the performance of international institutions by donor states seeking to allocate their resources more efficiently. Interestingly, however, not all highly rated institutions have been “rewarded” with increased contributions, while not all poorly rated institutions have been “punished” with funding cuts or freezes. I argue that the financial impact of performance indicators is contingent upon the relationship between institutions and other actors within their environment, with stronger effects occurring when institutions (1) are subject to a higher degree of resource competition and (2) possess deeper and more extensive operational alliances with actors above and below the state. I test the argument using a mixed-methods strategy that draws on a variety of original sources, including key informant interviews and a new dataset covering fifty-three institutions over the period 2000–2016. The findings enhance our understanding of when and why comparative performance indicators influence resource flows to assessed entities.
Rethinking Authoritarian Power: The Logistics Space and Authoritarian Practices in and between Secondary Port Cities of the Global South
Authors: Jenss Alke , Schuetze Benjamin 
Published: December 2020

AbstractHow to rethink authoritarian power in ways that better account for authoritarian connections beyond nation-state boundaries? By reconceptualizing the context in which to analyze authoritarian power, we bring to light transregional authoritarian connections between the secondary port cities Aqaba/Jordan and Buenaventura/Colombia. We demonstrate that processes of privatization and a continuum of pre-emptive, technocratizing, and repressive authoritarian practices with the overall purpose of enabling capital accumulation occur in a remarkably entangled manner in both locales, even if located at seemingly unconnected geographical sites. By thinking of Aqaba and Buenaventura as occupying the same “transregional authoritarian logistics space” (TALS), we understand Buenaventura through Aqaba, and vice versa. This crisscrossing of established notions of context has important implications for our understanding of authoritarianism and future transregional research designs. As a unit of analysis, the TALS allows us to highlight the role of global logistics players and “developmental aid” agencies—actors rarely discussed in literature on authoritarianism—in rearticulating boundaries within and beyond the nation-state based on class and race. Our contribution calls for an understanding of authoritarian power as transregionally entangled, rather than separate and limited to the nation-state and builds on literatures on authoritarian practices, authoritarian neoliberalism, critical logistics, and transregional connections.
Engaging the “Animal Question” in International Relations
Authors: Fougner Tore 
Published: December 2020

AbstractBy raising the “animal question” in International Relations (IR), this essay seeks to contribute not only to put animals and human–animal relations on the IR agenda, but also to move the field in a less anthropocentric and non-speciesist direction. More specifically, the essay does three things: First, it makes animals visible within some of the main empirical realms conventionally treated as the subject matter of IR. Second, it reflects on IR's neglect of animals and human–animal relations in relation to both how IR has been constituted as a field and the broader socio-cultural context in which it is embedded. Third, it explores various ways in which IR scholars can start incorporating and take animals and human–animal relations seriously in studies on international relations.
Higher West Nile Virus Infection in Aedes albopictus (Diptera: Culicidae) and Culex (Diptera: Culicidae) Mosquitoes From Lower Income Neighborhoods in Urban Baltimore, MD
Authors: Rothman Sarah E , Jones Jennifer A , LaDeau Shannon L , Leisnham Paul T 
Published: December 2020

Abstract
The temperate United States has experienced increasing incidence of mosquito-borne diseases. Recent studies conducted in Baltimore, MD have demonstrated a negative relationship between abundances of Aedes albopictus (Skuse) and Culex mosquitoes and mean neighborhood income level, but have not looked at the presence of pathogens. Mosquitoes collected from five socioeconomically variable neighborhoods were tested for infection by West Nile, chikungunya, and Zika viruses in 2015 and 2016, and again from four of the neighborhoods in 2017. Minimum infection rates of pooled samples were compared among neighborhoods for each year, as well as among individual blocks in 2017. West Nile virus was detected in both Ae. albopictus and Culex pools from all neighborhoods sampled in 2015 and 2017. No infected pools were detected in any year for chikungunya or Zika viruses, and none of the target viruses were detected in 2016. Infection rates were consistently higher for Culex than for Ae. albopictus. Minimum infection rate was negatively associated with mean neighborhood income for both species in 2015. Although earlier work has shown a positive association between block-level abandonment and mosquito abundance, no association was detected in this study. Still, we demonstrate that viral infection in mosquito pools can differ substantially across adjacent urban neighborhoods that vary by income. Though trap security and accessibility often inform city sampling locations, detecting and managing arboviral risk requires surveillance across neighborhoods that vary in socioeconomics, including lower income areas that may be less accessible and secure but have higher infection rates.
Social Skills Instruments for Children with Autism Spectrum Disorder: A Critical Interpretive Synthesis
Authors: West Rebecca , Silverman Michael J 
Published: December 2020

Abstract
Identifying and critically analyzing the most frequently used social skills psychometric instruments (SSPI) for children with autism spectrum disorder (ASD) can inform future music therapy research and clinical practice. Therefore, the initial purpose of this critical interpretive synthesis was to identify the SSPI most frequently used as dependent measures in the Journal of Autism and Developmental Disorders (JADD) for children with ASD from 2012 to 2018. Results indicated that the Social Responsiveness Scale (n = 35), Autism Diagnostic Observation Schedule (n = 19), and Vineland Adaptive Behavior Scales (n = 15) were the most frequently used instruments. Congruent with critical interpretive synthesis methodology, we then identified the psychometric properties and advantages and disadvantages of the 9 most commonly used instruments. To compare these results with the existing music therapy literature, we also identified nonmusical SSPI used as dependent measures in music therapy research for children with ASD in studies published between 2012 and 2018. In comparing the data sets, music therapy researchers used 5 of the 9 SSPI we identified from our JADD review. Understanding frequently used SSPI has applications for consultation and communication with other professionals as well as how future music therapy research is conducted. Implications for clinical practice, limitations of the study, and suggestions for future research are provided.
Economic Significance of Continued Improvement of Loblolly Pine Genetics and Its Efficient Deployment to Landowners in the Southern United States
Authors: McKeand Steven E , Payn Kitt G , Heine Austin J , Abt Robert C 
Published: December 2020

AbstractThe economic consequence of continuing or increasing the tree improvement efforts for loblolly pine (Pinus taeda L.) in the southern United States is immense. For the more than one million acres planted each year with germplasm from the North Carolina State University Cooperative Tree Improvement Program, the present value of continuing current tree breeding efforts and deploying the genetic gains to landowners is estimated to be more than $1.7 billion at current prices. The present value of increasing the rate of genetic gain from 1% per year to 1.1% per year is $211 million. These analyses can be used to justify maintaining and even increasing efforts in tree improvement. With the aggressive fourth-cycle breeding program underway and plans for fifth-cycle breeding and deployment strategies being developed, we have every reason to believe that this trend for at least 1% gain per year will continue for decades, provided the resources to continue tree improvement efforts remain available. Even a modest increase in genetic gain per year would be justification for stakeholders to invest more than $12 million per year to realize this gain.
Spectrum of Cardiovascular Diseases in Children During High Peak Coronavirus Disease 2019 Period Infection in Northern Italy: Is There a Link?
Authors: Fabi Marianna , Filice Emanuele , Andreozzi Laura , Conti Francesca , Gabrielli Liliana , Balducci Anna , Vergine Gianluca , Cicero Cristina , Iughetti Lorenzo , Guerzoni Maria Elena , Corinaldesi Elena , Lazzarotto Tiziana , Pession Andrea , Lanari Marcello 
Published: December 2020

Abstract

Background
Children with coronavirus disease-2019 (COVID-19) have a milder clinical course than adults. We describe the spectrum of cardiovascular manifestations during a COVID-19 outbreak in Emilia-Romagna, Italy.

Methods
A cross-sectional multicenter study was performed, including all patients diagnosed with Kawasaki disease (KD), myocarditis, and multisystem inflammatory syndrome in children (MIS-C) from February to April 2020. KD patients were compared with those diagnosed before the epidemic.

Results
KD: 8 patients (6/8 boys, all negative for severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]): complete presentation in 5/8, 7/8 immunoglobulin (IVIG) responders, and 3/8 showed transient coronary lesions (CALs). Myocarditis: one 5-year-old girl negative for SARS-CoV-2 and positive for parvovirus B19. She responded to IVIG. MIS-C: 4 SARS-CoV-2-positive boys (3 patients with positive swab and serology and 1 patient with negative swab and positive serology): 3 presented myocardial dysfunction and pericardial effusion, and 1 developed multicoronary aneurysms and hyperinflammation; all responded to treatment. The fourth boy had mitral and aortic regurgitation that rapidly regressed after steroids.

Conclusions
KD, myocarditis, and MIS-C were distinguishable cardiovascular manifestations. KD did not show a more aggressive form compared with previous years: coronary involvement was frequent but always transient. MIS-C and myocarditis rapidly responded to treatment without cardiac sequelae despite high markers of myocardial injury at the onset, suggesting a myocardial depression due to systemic inflammation rather than focal necrosis. Evidence of actual or previous SARS-CoV-2 infection was documented only in patients with MIS-C.
On computable aspects of algebraic and definable closure
Authors: Ackerman Nathanael , Freer Cameron , Patel Rehana 
Published: December 2020

Abstract
We investigate the computability of algebraic closure and definable closure with respect to a collection of formulas. We show that for a computable collection of formulas of quantifier rank at most $n$, in any given computable structure, both algebraic and definable closure with respect to that collection are $\varSigma ^0_{n+2}$ sets. We further show that these bounds are tight.
Analysis of U.S. Pacific Command Area of Operations Military Medical Transportations of Adult Patients, 2008 to 2018
Authors: Pawlukiewicz Alec J , Bridwell Rachel E , Carius Brandon M , Schauer Steven G , Maddry Joseph K , Davis William T 
Published: December 2020

AbstractIntroductionWith more than 370,000 military and civilian personnel stationed across Pacific Command (PACOM), medical evacuation in this largest command presents unique challenges. The authors describe medical evacuations analyzed from the U.S. Air Force Transportation Command Regulating and Command & Control Evacuation System (TRAC2ES) in PACOM.Materials and MethodsWe performed a retrospective review of all TRAC2ES medical records for medical evacuations of adult patients from the PACOM theater of operations conducted between January 1, 2008 and December 31, 2018. We abstracted free text data entry in TRAC2ES to characterize the diagnoses requiring patient movement. Data are presented using descriptive statistics.ResultsDuring this 11-year period, 3,328 PACOM TRAC2ES encounters met inclusion criteria. Of these evacuations, 65.8% were male and were comprised mostly of active duty military (1,600, 48.1%) and U.S. civilians (1,706, 51.3%). Most transports originated in Japan (1,210 transports, 36.4%) or Guam (924 transports, 27.8%) with Hawaii (1,278 transports, 38.4%) as the most frequent destination. The majority of evacuations were routine (72.5%) with only 4.9% urgent evacuations. Medical conditions (2,905 transports, 87%) accounted for the largest proportion of transports, surpassing injuries (442 transports, 13%). The most common reasons for medical transports were behavioral health (671 transports, 20.2%) and cardiovascular disease (505 transports, 15.1%).ConclusionsThe majority of medical evacuations in PACOM were because of medical illness with routine precedence category, mirroring the largely noncombat operations occurring across this large area.
Geographic Variation in Initiation of Evidence-based Psychotherapy Among Veterans With PTSD
Authors: Dufort Vincent M , Bernardy Nancy , Maguen Shira , Hoyt Jessica E , Litt Eric R , Patterson Olga V , Leonard Christine E , Shiner Brian 
Published: December 2020

Abstract

Introduction
The United States Department of Veterans Affairs (VA) has invested in implementation of evidence-based psychotherapy (EBP) for post-traumatic stress disorder (PTSD) for over a decade, resulting in slow but steady uptake of these treatments nationally. However, no prior research has investigated the geographic variation in initiation of EBP. Our objectives were to determine whether there is geographic variation in the initiation of EBP for PTSD in the VA and to identify patient and clinic factors associated with EBP initiation.

Materials and Methods
We identified VA patients with PTSD who had not received EBP as of January 2016 (N = 946,667) using retrospective electronic medical records data and determined whether they initiated EBP by December 2017. We illustrated geographic variation in EBP initiation using national and regional maps. Using multivariate logistic regression, we determined patient, regional, and nearest VA facility predictors of initiating treatment. This study was approved by the Veterans Institutional Review Board of Northern New England.

Results
Nationally, 4.8% (n = 45,895) initiated EBP from 2016 to 2017, and there was geographic variation, ranging from none to almost 30% at the 3-digit ZIP code level. The strongest patient predictors of EBP initiation were the negative predictor of being older than 65 years (OR = 0.47; 95% CI, 0.45-0.49) and the positive predictor of reporting military-related sexual trauma (OR = 1.96; 95% CI, 1.90-2.03). The strongest regional predictors of EBP initiation were the negative predictor of living in the Northeast (OR = 0.89; 95% CI, 0.86-0.92) and the positive predictor of living in the Midwest (OR = 1.47; 95% CI, 1.44-1.51). The only nearest VA facility predictor of EBP initiation was the positive predictor of whether the facility was a VA Medical Center with a specialized PTSD clinic (OR = 1.23; 95% CI, 1.20-1.26).

Conclusion
Although less than 5% of VA patients with PTSD initiated EBP, there was regional variation. Patient factors, region of residence, and nearest VA facility characteristics were all associated with whether patients initiated EBP. Strengths of this study include the use of national longitudinal data, while weaknesses include the potential for misclassification of PTSD diagnoses as well as the potential for misidentification of EBP. Our work indicates geographic areas where access to EBP for PTSD may be poor and can help target work improving access. Future studies should also assess completion of EBP for PTSD and related symptomatic and functional outcomes across geographic areas.