bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of wait times on oncological outcome in high‐risk patients with endometrial cancer
Authors: Mitric Cristina , Matanes Emad , Wissing Michel , Amajoud Zainab , Abitbol Jeremie , Yasmeen Amber , López‐Ozuna Vanessa , Eisenberg Neta , Laskov Ido , Lau Susie , Salvador Shannon , Gotlieb Walter H. , Kogan Liron 
Published: April 2020

AbstractObjectiveTo evaluate the impact of surgical wait times on outcome of patients with grade 3 endometrial cancer.MethodsAll consecutive patients surgically treated for grade 3 endometrial cancer between 2007 and 2015 were included. Patients were divided into two groups based on the time interval between endometrial biopsy and surgery: wait time from biopsy to surgery ≤12 weeks (84 days) vs more than 12 weeks. Survival analyses were conducted using log‐rank tests and Cox proportional hazards models.ResultsA total of 136 patients with grade 3 endometrial cancer were followed for a median of 5.6 years. Fifty‐one women (37.5%) waited more than 12 weeks for surgery. Prolonged surgical wait times were not associated with advanced stage at surgery, positive lymph nodes, increased lymphovascular space invasion, and tumor size (P = .8, P = 1.0, P = .2, P = .9, respectively). In multivariable analysis adjusted for clinical and pathological factors, wait times did not significantly affect disease‐specific survival (adjusted hazard ratio [HR]: 1.2, 95% confidence interval [CI], 0.6‐2.5, P = .6), overall survival (HR: 1.1, 95% CI, 0.6‐2.1, P = .7), or progression‐free survival (HR: 0.9, 95% CI, 0.5‐1.7, P = .8).ConclusionProlonged surgical wait time for poorly differentiated endometrial cancer seemed to have a limited impact on clinical outcomes compared to biological factors.
A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors
Authors: Kasai Yosuke , Mahuron Kelly , Hirose Kenzo , Corvera Carlos U. , Kim Grace E. , Hope Thomas A. , Shih Brandon E. , Warren Robert S. , Bergsland Emily K. , Nakakura Eric K. 
Published: April 2020

AbstractBackground and ObjectivesWe classified the extent of mesenteric mass (MM) involvement that predicts challenging mesenteric lymph node dissection (mLND) by minimally invasive surgery (MIS) for ileal neuroendocrine tumors (i‐NETs).MethodsPatients who underwent surgery for i‐NETs were retrospectively reviewed. MM involvement was classified as region‐0: no MM; region‐1: >2 cm from the origins of the ileocolic artery/vein; region‐2: ≤2 cm from the origins; and region‐3: more proximal superior mesenteric artery/vein. Logistic regression analysis was used to evaluate the predictive value of MM regions for gross positive mesenteric margin (mR2) and/or conversion among the MIS cohort. The open surgery cohort was used as a reference for mR2 rates.ResultsOf 108 patients, 83 patients (77%) underwent MIS. MMs in region‐2 and region‐3 were independent risk factors for mR2 and/or conversion (odds ratio [95% confidence interval]: 4.25 [1.17‐16.4] and 8.51 × 107 [11.0‐], respectively, against regions‐0 and 1]. mR2 rates of MIS and open surgery cohorts per region did not differ significantly (4% and 7% for regions‐0 and 1; 17% and 25% for region‐2; and 100% and 83% for region‐3).ConclusionsThe novel stratification of MM regions was predictive of challenging mLND by MIS. Surgeons should have a low threshold for conversion for MMs in proximal regions.
The Impact of Posttraumatic Stress Disorder and Moral Injury on Women Veterans’ Perinatal Outcomes Following Separation From Military Service
Authors: Nillni Yael I. , Shayani Danielle R. , Finley Erin , Copeland Laurel A. , Perkins Daniel F. , Vogt Dawne S. 
Published: April 2020

AbstractPosttraumatic stress disorder (PTSD) has been found to lead to several adverse perinatal outcomes in the general population. Preliminary research has found that women veterans with PTSD have an increased prevalence of preterm birth, gestational diabetes, and preeclampsia. Less research has examined the role of moral injury (MI) in perinatal outcomes. This longitudinal survey study examined the impact of PTSD symptoms and MI on prospectively assessed adverse perinatal outcomes among women who became pregnant in the first 3 years after separating from U.S. military service (N= 318). The Moral Injury Events Scale was used to assess the degree to which individuals experienced distress related to transgressions of deeply held moral beliefs, and the Primary Care PTSD Screen forDSM‐5(PC‐PTSD) was used to assess PTSD symptoms. Perinatal outcomes included experiencing an adverse pregnancy outcome (e.g., preterm birth, gestational diabetes), postpartum depression and/or anxiety, and perceived difficult pregnancy. Although both PTSD symptoms, adjusted odds ratio (aOR) = 1.16, 95% CI [1.00, 1.35]; and MI, aOR= 1.27, 95% CI [1.06, 1.41], emerged as significant predictors of adverse pregnancy outcomes, only PTSD symptoms were a significant predictor of postpartum depression and/or anxiety, aOR= 1.43, 95% CI [1.22, 1.68], and perception of a difficult pregnancy, β = .31, when controlling for lifetime trauma exposure, age, socioeconomic status, and ethnic/racial minority status. The results indicate that both PTSD symptoms and MI are associated with adverse perinatal outcomes, supporting the potential need to screen for both PTSD and MI during the perinatal period.
Prognostic Significance of Smoking in Human Papillomavirus–Positive Oropharyngeal Cancer Under American Joint Committee on Cancer Eighth Edition Stage
Authors: Chidambaram Smrithi , Nakken Erik R. , Kennedy William , Thorstad Wade L. , Chen Stephanie Y. , Pipkorn Patrik , Zevallos Jose P. , Mazul Angela L. 
Published: April 2020

ObjectiveTo determine the prognostic significance of smoking in human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) when considering American Joint Committee on Cancer eighth edition (AJCC‐8) stage.Study DesignRetrospective cohort study.MethodsThree hundred seventeen HPV‐positive OPSCC patients with known AJCC‐8 stage and smoking status (<10 or ≥10 pack‐years) seen at a tertiary center from 1997 to 2017 were studied. We used the Kaplan‐Meier method to compare 5‐year overall survival (OS) by smoking status and by clinical AJCC‐8 stage and smoking status combined. Hazard ratios (HRs) were estimated with Cox proportional hazard regression for the independent effects of smoking and AJCC‐8 stage. We also studied pathologic stage and estimated the combined effects of smoking and clinical stage.ResultsThe ≥10 pack‐years smokers had worse 5‐year OS than <10 pack‐years smokers (93.6%; 95% confidence interval (CI): 89.7‐97.8 vs. 82.3%; 95% CI: 76.0%‐89.1%). When stratified by AJCC‐8 clinical stage, only stage I <10 pack‐years smokers (98.7%; 95% CI: 96.3%‐100.0%) had significantly better 5‐year OS than their ≥10 pack‐years (84.8%; 95% CI: 76.4%‐94.1%) counterparts. In a multivariable analysis, ≥10 pack‐years smoking was associated with increased hazard of death when adjusting for AJCC‐8 clinical (HR: 2.52; 95% CI: 1.16‐5.46) and pathologic (HR: 5.21; 95% CI: 1.47‐18.5) stage. In both analyses, stage III patients demonstrated worse survival than stage I, and smoking had greater impact at lower stages.ConclusionsSmoking is a negative prognosticator in HPV‐positive OPSCC and interacts with AJCC‐8 clinical stage. It is important to understand the impact of smoking in HPV‐positive disease when considering treatment plans and deintensification trials.Level of Evidence2b Laryngoscope, 130: 1961–1966, 2020
Optimization of mixed silanes agent solution and curing process for composite γ‐glycidoxypropyl trimethoxysilane (γ‐GPS)/bis‐1.2‐(triethoxysilyl)ethane (BTSE) silane film on Q235 steel surface
Authors: Sun Z.D. , Yang Y.N. , Li Q.K. , Liu J.G. , Xu Q. , Yan C.W. 
Published: April 2020

AbstractIn this investigation, the mixed γ‐GPS/BTSE silane solution for preparing well adhered composite γ‐GPS/BTSE silane film on Q235 carbon steel surface has been successfully optimized by orthogonal test, and the curing process parameters of temperature and time have also been optimized. The results indicate that the optimized hydrolysis parameters for mixed silanes agent solution are as follows: Vethanol/Vwater 3 : 1, Vγ‐GPS/VBTSE 2 : 3, Vsilanes 6 vol.%, pH 4.0 and hydrolysis time 72 h. In addition, the optimized curing condition for composite γ‐GPS/BTSE silane film is 120 °C and 30 min. After immersion in the optimized mixed γ‐GPS/BTSE silanes agent solution and curing under the optimized condition, the prepared composite γ‐GPS/BTSE silane film on Q235 steel surface can have an adhesion strength of 24.52 MPa to underlying steel substrate.
Timed Up and Go Test and the Risk of Parkinson's Disease: A Nation‐wide Retrospective Cohort Study
Authors: Yoo Jung Eun , Jang Wooyoung , Shin Dong Wook , Jeong Su‐Min , Jung Hee‐Won , Youn Jinyoung , Han Kyungdo , Kim Bongseong 
Published: April 2020

AbstractBackgroundIf mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD.ObjectivesTo investigate whether the Timed Up and Go test is associated with PD.MethodsWe included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data.ResultsDuring the median follow‐up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20–1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63–2.92).ConclusionAn indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development. © 2020 International Parkinson and Movement Disorder Society
Pain Education in the Context of Non‐Specific Low Back Pain: The Lived Experience of the Physiotherapist. An Interpretive Phenomenological Analysis
Authors: Wellman Josh , Murray Luke , Hebron Clair , Vuoskoski Pirjo 
Published: April 2020

AbstractObjectivesThe aim of this study was to explore the physiotherapists' lived experiences of providing pain education (PE), to people living with non‐specific low back pain (NSLBP). In previous studies, PE has been associated with positive clinical outcomes within the physiotherapeutic management of NSLBP. However, the meaning of providing PE, as experienced by physiotherapists, has not been specifically explored.MethodsThis study adopted a hermeneutic phenomenological approach to explore PE experiences. Six semi‐structured interviews were conducted, interviews were transcribed and analysed in line with the ‘interpretative phenomenological analysis’ framework.ResultsFive main thematic meaning structures emerged: Experienced significance of assessment in understanding NSLBP, PE as explaining the nature of NSLBP, Experienced challenges in providing PE, individualisation as key to PE for NSLBP and Reassurance as central to PE for people living with NSLBP.ConclusionsThe significance of subjective assessment, was a key component of PE, as experienced by participants. However, differences were noted between participants in addressing the sense of assessment; in seeking a physiotherapeutic understanding of the NSLBP, and in seeking to understand the situation of those who are in pain. Within the participant experience, the significance of ‘patient’ reassurance was highlighted, related to the individualisation and outcome of PE. Reassurance, as described by participants, was emotive and practically grounded and linked with physical activity promotion. Individualisation in PE was meaningfully related to language modification and developing positive therapeutic relationships. Physiotherapists described PE particularly challenging related to pain chronicity and psychosocial factors, which may have significant implications to practice.
Metabolic reprogramming in childhood acute lymphoblastic leukemia
Authors: Sbirkov Yordan , Burnusuzov Hasan , Sarafian Victoria 
Published: April 2020

AbstractThe first observations of altered metabolism in malignant cells were made nearly 100 years ago and therapeutic strategies targeting cell metabolism have been in clinical use for several decades. In this review, we summarize our current understanding of cell metabolism dysregulation in childhood acute lymphoblastic leukemia (cALL). Reprogramming of cellular bioenergetic processes can be expected in the three distinct stages of cALL: at diagnosis, during standard chemotherapy, and in cases of relapse. Upregulation of glycolysis, dependency on anaplerotic energy sources, and activation of the electron transport chain have all been observed in cALL. While the current treatment strategies are tackling some of these aberrations, cALL cells are likely to be able to rewire their metabolism in order to escape therapy, which may contribute to a refractory disease and relapse. Finally, here we focus on novel therapeutic approaches emerging from our evolving understanding of the alterations of different metabolic networks in lymphoblasts.
Influence of long‐term storage on the performance of polyamide‐based nanocomposites: Role of nanoclay fillers
Authors: Médéric Pascal , Aït Hocine Nourredine , Hassan Hanaya 
Published: April 2020

AbstractThis work deals with the effects of long‐term storage on the properties of polyamide 12 filled with nanoclay mass fractions of 0, 3, and 5%. More precisely, such nanocomposites were prepared using internal mixer, and then stored in a room under ambient conditions, for 6 years, protected from light and temperature variations. The changes in their thermal, mechanical, and rheological properties were analyzed, in relationship with the microstructure changes. Various analyses and tests were conducted, including wide‐angle X‐ray diffraction experiments, water mass loss evaluation, differential thermal analyses, strain sweep tests on solid‐state specimens, as well as time sweep and oscillatory shear measurements on melt‐state specimens. The results mainly revealed the effects of the absorbed water on the changes of the aged nanocomposite performances and highlighted the positive role of nanoclay platelets in the preservation of processability and end‐use properties.
Fluid compensation in response to disappearance of the meaning of work
Authors: Meng Liang , Ouyang Feng 
Published: April 2020

AbstractThis study examined one's compensatory response to the sudden disappearance of the meaning of work. In a lab experiment, the unexpected termination of a preceding task was found to enhance one's labor supply in an irrelevant ensuing task, which provided direct support for one's pursuit of meaning and the fluid compensation strategy proposed by the Meaning Maintenance Model.
Morphology and mechanical investigation of microcellular injection molded carbon fiber reinforced polypropylene composite foams
Authors: Nobe Rie , Qiu Jianhui , Kudo Makoto , Zhang Guohong 
Published: April 2020

AbstractEmploying microcellular injection molding technology, carbon fiber (CF)/polypropylene (PP) composite foams have been prepared. The influences of injection molding conditions and CF amounts relating to the flexural and impact performances have also been studied. X‐ray computed tomography scanning has been used for morphological observation. For the flexural specimens, although the solid skin and foamed core layers can be confirmed significantly, the intermediate layer is indistinct. Moreover, the stretched cells can be confirmed dramatically for the Charpy impact specimens. The cell density increases to 12.0 × 103 cell/cm2 when the nitrogen content is 1%. By contrast, the cell densities decrease with the injection speed and CF content increasing accordingly. Further, the maximum specific flexural modulus and Charpy impact strength of the foams can achieve 14 GPa/(g/cm3) and 6.2 kJ/m2, respectively, at the CF content of 30 wt%. Finally, the microcellular structure with the highest cell density can be confirmed with the nitrogen content of 1 wt%, the injection speed of 50 mm/s and the CF content of 10 wt%. Obviously, the CF contents have shown strong influences on the mechanical behaviors of the CF/PP composite foams compared with nitrogen contents or injection speeds.
Ultrasound‐Assisted Extraction of Fucoidan from Vietnamese Brown Seaweed Sargassum mcclurei and Testing Bioactivities of the Extract
Authors: Thao My Phan Le , Sung Vo Van , Dat Tran Do , Nam Hoang Minh , Phong Mai Thanh , Hieu Nguyen Huu 
Published: April 2020

AbstractIn this study, fucoidan was extracted from the Vietnamese brown seaweed Sargassum mcclurei by ultrasound – assisted extraction method (UAE) using ethanol as a solvent. The effects of single factors on total polysaccharide (TPS) content were then investigated, followed by the screening of main factors affecting TPS content based on their effect sizes and p‐values in analysis of variance. The response surface methodology using the Box‐Behnken design was applied to investigate simultaneous effects of four main factors including solvent‐to‐material ratio, extraction time, ultrasonic power, and extraction temperature. The optimal conditions for fucoidan extraction were identified with solvent‐to‐material ratio of 24 : 1 mL/g, extraction time of 49 min, ultrasonic power of 360 W, and extraction temperature of 54
. The highest yield of TPS obtained under these conditions was 7.1203 mg/g. Besides, extraction of fucoidan using hot water method was also carried out to compare with UAE method in terms of TPS content. The bioactivity tests showed the extract had the anti‐oxidation activity with the half‐maximal inhibitory concentration (IC50) value of 0.4261
0.0008 mg/mL, cytotoxic effect on breast carcinoma cells and human lung carcinoma with IC50 values of 95.80
4.75 and 129.00 ± 0.66 μg/mL, respectively.
Tandem Oxidative Pudovik Reaction Using Fe3O4@SiO2‐Metformin‐Cu (II) as an Efficient and Recoverable Catalyst
Authors: Babazadeh Sahar , Kazemi Miraki Maryam , Pazoki Farzane , Heydari Akbar 
Published: April 2020

AbstractOne‐pot condensation of benzyl alcohol with di‐alkyl/ aryl phosphite under free solvent conditions was investigated in the presence of Fe3O4@SiO2‐Met‐Cu (II) as a recyclable heterogeneous catalyst and aqueous tert‐butyl hydroperoxide (TBHP) as the oxidant. The advantages of this protocol include good to excellent yields, easy workup, short reaction time and good reusability to 4 cycles. Also, interactions between metal and ligand in the Fe3O4@SiO2‐Metformin complex is studied by using theoretical calculations
Emission Enhancement of Perylene‐Bisimide‐Based Organogel Triggered by Ultrasound
Authors: Li Xin , Li Yajuan , Feng Guoliang , Wang Tao , Ren Jujie , Yu Xudong 
Published: April 2020

AbstractDesign of mechanostress controlled luminescence in supramolecular gel is still a challenge. Herein, the molecular gelators PBI1 and PBI2 based on perylene bisimide (PBI) chromophores are prepared and characterized. With additional non‐covalent hydrogen bonding interactions between acid and imidazole units, stable gelator PBI2 self‐assembles into entangled supramolecular fibers that forms fluorescent‐enhancement gels triggered by ultrasound in DMSO. Moreover, the structure variation and gelation approaches on the gel properties are also contrasted and studied with several experiments.
Aqueous‐Phased Electrospun Bioactive Glass Mineralized Gelatin‐Pectin Hybrid Composite Fiber Matrix For 7‐Dehydrocholesterol Delivery
Authors: Gupta Nidhi , Goel Himansh , Santhiya Deenan , Srivastava Chandra Mohan , Mishra Sarita , Rai Pragya 
Published: April 2020

AbstractUltrafine fibers and a bioactive glass mineralized fibrous mat of gelatin‐pectin blends were produced by electrospinning in an aqueous phase. Herein, the gelatin‐pectin blend was used as a template for the in situ mineralization of bioactive glass particles during the electrospinning of gelatin‐pectin based hybrid composite fiber matrix. Further, in situ mineralized bioactive glass along with the fibrous mat functioned as a site for 7‐dehydrocholesterol, i. e., vitamin‐D precursor. This engineered fibrous mat resulted in the sustained release of the drug, which is necessary for the strengthening of the neo regenerated bones. The fibrous mat also exhibited excellent bioactivity in simulated body fluid. Additionally, the hybrid composite fiber mat was observed to possess remarkable cytocompatibility with osteoblast cells and showed cell proliferation on the surface of the fibrous mat.
Silver Nanoparticles Supported on Mesoporous Triazine Carbon Material: A Versatile Catalyst for Reduction of Nitroaromatic Compounds
Authors: Emadi Farzaneh , Nemati Firouzeh , Elhampour Ali 
Published: April 2020

AbstractIn this study, a new precursor was synthesized form the reaction of melamine and chloroacetonitrile. By using this pre‐material, the new mesoporous triazine based‐carbon material was prepared during ionothermal process with the help of ZnCl2, and used as the excellent support for silver nano‐particles. The new nano‐catalyst was named Ag/mCTF(mesoporous Carbon Triazine Framework), and fully characterized by various analytical methods including Fourier transformed infrared spectroscopy (FT‐IR), field emission scanning electron microscopy (FE‐SEM), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD) and thermogravimetric analysis (TGA). The catalyst ability of Ag/mCTF was survived in the reduction reaction of nitroaromatic compounds. The results show that this new catalyst produced anilines in good yields in benign condition. The other merit of this heterogeneous catalyst was high recyclability without significant decrease in its performance.
Aryl Ethynylpyrene as Fluorescent Sensors for Cyanide Ions in Aqueous Media
Authors: Vongnam Kunnigar , Chansaenpak Kantapat , Sukwattanasinitt Mongkol , Rashatasakhon Paitoon 
Published: April 2020

AbstractThree derivatives of aryl ethynylpyrene are successfully synthesized via a Sonogashira coupling‐Knoevenagel condensation sequence. Two of these compounds exhibit excellent selective fluorescent enhancement by CN− in aqueous media with detection limits of 0.066 and 0.087 μM. The 1H‐NMR analysis suggests that the sensing mechanism involves a nucleophilic addition of CN− to the reactive olefinic group. In the solution phase, these sensors can be used for the determination of spiked CN− in real water samples at 5 and 10 μM with relative standard deviation of below 4 %. When fabricated into paper‐based sensors, they can be used to detect CN− in aqueous media at the micromolar levels by naked eyes.
Thermal effects
Authors: Liang Jinsong , Zhang Panyue , Cai Yajing , Wang Qingyan , Zhou Zeyan 
Published: April 2020

AbstractThis review paper focuses on the researches published in 2019 in the field of thermal effects in wastewater and solid waste treatment. The content of this review paper includes five parts: wastewater and sludge treatment, nutrient removal and recovery, membrane technology, heavy metal removal and immobilization, and organic waste utilization. © 2020 Water Environment FederationPractitioner points

Thermal effect plays an important role in treatment of wastewater and sewage sludge.

Recovery of nitrogen and phosphorus from wastewater and sewage sludge reduces environmental pollution and offers new products.

Temperature improves removal and recovery of heavy metals and organic wastes.