bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Testing in the Pediatric Nephrology Clinic: Understanding Families' Experiences
Authors: Nevin Suzanne M. , McLoone Jordana , Wakefield Claire E. , Kennedy Sean E. , McCarthy Hugh J. 
Published: December 2020

AbstractGenomics is rapidly being integrated into the routine care of children and families living with renal disease, principally as a diagnostic tool but also to direct therapy, identify at-risk relatives, and facilitate family planning. However, despite significant progress in understanding the genetic heterogeneity of inherited renal disease, the impact of genetic testing on parents and families of affected children is not well understood. This study aimed to investigate the experiences of families undergoing genetic testing, the psychosocial impact of receiving a genetic test result, and parent information and support needs. In-depth semistructured interviews were conducted with 26 parents of pediatric patients (<18 years of age) who had undergone genomic investigation for a suspected genetic renal disease at two tertiary pediatric nephrology services. Interviews were transcribed verbatim, coded, using NVivo software, and thematic analysis was undertaken. Key themes included emotional adjustment to a genetic diagnosis, the importance of parent-provider relationships, empowerment through social connection, and the value of family-centered care. Results highlighted the wide-ranging psychosocial impact of genetic testing on parents, as well as the importance of patient-support networks in enabling parents/families to cope and adapt. Targeted approaches to enhance communication of genetic information and the development of tailored resources to address parents' genetics and health service needs may lead to more satisfactory experiences of genetic testing.
Outcomes of Monochorionic, Diamniotic Twin Pregnancies with Prenatally Diagnosed Intertwin Weight Discordance
Authors: Sobhani Nasim C. , Sparks Teresa N. , Gosnell Kristen A. , Rand Larry , Gonzalez Juan M. , Feldstein Vickie A. 
Published: December 2020

Objective Monochorionic, diamniotic (MCDA) twin pairs are predisposed to various pregnancy complications due to the unique placental angioarchitecture of monochorionicity. Few studies have evaluated the outcomes of weight-discordant MCDA pairs without selective fetal growth restriction (SFGR) or the risk factors for development of SFGR. This study aims to describe the natural history of expectant, noninvasive management of weight-discordant MCDA twins and to evaluate risk factors associated with progression to SFGR.
Study Design This was a retrospective cohort study at a single, tertiary care center in the United States. All MCDA twins with isolated intertwin weight discordance (ITWD) ≥ 20% diagnosed before 26 weeks' gestational age (GA) were included. The primary outcome of descriptive analyses was overall pregnancy outcome, incorporating both survival to delivery and GA at delivery, as defined by the North American Fetal Therapy Network. The secondary outcome was SFGR in one twin (defined as estimated fetal weight < 10% for GA) and factors associated with this progression. Only those with fetal ultrasound (US) within 4 weeks of delivery were included in this secondary analysis.
Results Among 73 MCDA pairs with ITWD, 73% had a good pregnancy outcome, with dual live delivery at a median GA of 33 weeks. Among the 34 pairs with adequate US follow-up, 56% developed SFGR. There were no differences in GA at delivery or discordance at birth between those who did and those who did not develop SFGR. There was a nonsignificant association between increasing ITWD at diagnosis and subsequent development of SFGR.
Conclusion Expectant, noninvasive management can be considered in MCDA twin pregnancies with ITWD ≥ 20% diagnosed before 26 weeks. This approach is associated with a good pregnancy outcome in the majority of cases, even after the development of SFGR in the smaller twin.
Key Points
Recurrent Preterm Birth Reduction by 17-Hydroxyprogesterone Caproate in Dichorionic/Diamniotic Twin Gestation
Authors: Megli Christina , Combs C. Andrew , Venkataramanan Raman , Lemon Lara , Caritis Steve N. 
Published: December 2020

Objective The study aimed to evaluate the impact of 17-hydroxyprogesterone caproate (17-OHPC) on recurrent preterm birth (PTB) in women with a prior PTB and a current dichorionic/diamniotic twin gestation.
Study Design We combined individual patient-level data from two prospective randomized placebo-controlled trials of prophylactic 17-OHPC in twin gestation and compared the rates of recurrent spontaneous PTB in those women with a prior singleton PTB randomized to placebo or 17-OHPC (250 mg weekly).
Results Only 7.4% of women with dichorionic/diamniotic twin gestation experienced a prior PTB. Among these 66 women, spontaneous delivery prior to 34 weeks occurred significantly less often (p = 0.03) in those randomized to 17-OHPC (20.6%) than in those randomized to placebo (46.9%). However, mean gestational length was not significantly different, and there was no statistically significant difference in composite neonatal outcome.
Conclusion 17-OHPC may be beneficial to women with a prior PTB and a current dichorionic/diamniotic twin gestation. These findings along with those reported by the Maternal Fetal Medicine Units Network in singletons suggest a common mechanism of action and a specific target population, those with a prior PTB, that may benefit from 17-OHPC treatment. A large prospective trial is needed to validate these findings.
Key Points
Damage detection & localization on composite patch repair under different environmental effects
Authors: Lambinet Florian , Khodaei Zahra Sharif 
Published: December 2020

Abstract
This paper presents a structural health monitoring (SHM) methodology for detecting damage in a composite bonded repair. The application of guided wave based techniques in a step-sanded bonded repair under operational and environmental load is thoroughly investigated. A two step damage detection and localization algorithm is presented, were in the first level the path damage indices (PDIs) for each transducer pair is calculated. The PDIs are then compared to a set threshold (based on the environmental and operational conditions) to increase the reliability of damage detection while reducing false alarm. In addition, a self-diagnosis approach based on electro-mechanical impedance (EMI) measure is proposed to identify the faulty sensors prior to the diagnosis. Once the transducer pairs with possible damage in their path has been selected, the second level of the proposed methodology is damage localization. To address the challenge of edge reflection, complex geometrical shape and layup of the repair patch which introduced anisotropy to the wave propagation, a novel damage detection based on probability imaging technique is proposed. The methodology is developed based on assigning probabilities of damage to the Minimal Intersection Score (MIS) to reduce the path saturation related to each path having the same probability of damage being located anywhere along it. The proposed method, uses a smart sub-division technique based on Voronoi Tessellation which is adaptable to any shape (circular, rectangular, elliptical). The reliability of the proposed method is then demonstrated with experimental results on a composite step-sanded repair subjected to impact damage under vibration and temperature variations, and the choice of input parameters such as wave form and excitation frequency on the probability of detecting damage is demonstrated.
Multifractal analysis of glaciers in the Lombardy region of the Italian Alps
Authors: Carpineti Marina , Rossoni Andrea , Senese Antonella , Maragno Davide , Diolaiuti Guglielmina A , Vailati Alberto 
Published: December 2020

Abstract
Glaciers are continuously monitored to detect their spatial extension and time evolution since they are the best witnesses of climate changes. There is a particular interest for Italian glaciers in the Alps as there is evidence that they are melting at a faster rate than those located in other regions of the globe. The determination of the perimeters of glaciers represents an effective method to evaluate the area covered by them. The availability of data for the perimeters encompassing several years suggests the opportunity of correlating the morphological variations in time with the properties of their shrinkage. In this work, we investigate the multifractal properties of the perimeters of the Lombardy glaciers in the Italian Alps. We characterize the area and perimeter distributions of the population of glaciers and we show that the distribution of perimeters exhibits a marked peak, not present in the distribution of areas. We analyze the area-perimeter relation, which is characterized by a power-law behavior that indicates a fractal structure of the perimeters with fractal dimension 1.2, independently from the size of the glaciers. We investigate the multifractal spectra of perimeters and we show that their features are strongly correlated with the area of the glaciers. Finally, we study the time evolution of the area and perimeter of glaciers and we detect the existence of a large class of glaciers whose perimeters increase while their areas decrease. We show that this behavior has a well definite counterpart in their multifractal spectra.
Irregular collective dynamics in a Kuramoto–Daido system
Authors: Clusella Pau , Politi Antonio 
Published: December 2020

Abstract
We analyze the collective behavior of a mean-field model of phase-oscillators of Kuramoto–Daido type coupled through pairwise interactions which depend on phase differences: the coupling function is composed of three harmonics. We provide convincing evidence of a transient but long-lasting chaotic collective chaos, which persists in the thermodynamic limit. The regime is analyzed with the help of clever direct numerical simulations, by determining the maximum Lyapunov exponent and assessing the transversal stability to the self-consistent mean field. The structure of the invariant measure is finally described in terms of a resolution-dependent entropy.
Dose Setting for Dermal Absorption Studies on Dried Foliar Residues
Authors: Morgan Neil , Hewitt Nicola J , Felkers Edgars , Wiemann Christiane , Kluxen Felix M , Kuster Christian J 
Published: December 2020

Abstract
Currently, the standard approach to estimate systemic exposure of workers after contact with dried pesticide residues on crops during re-entry activities relies on using the highest identified dermal absorption value for aqueous spray dilutions. However, recent dermal absorption studies with dried residues and their respective in-use dilutions have shown that this is likely to significantly overestimate their dermal penetration potential and, thus, predicted systemic exposure. The choice of appropriate dose levels for these dermal absorption studies has not been defined. Moreover, actual skin loading during re-entry tasks may differ significantly from that achieved by applying a fixed volume of an aqueous dilution, which is the standard practice in generic dermal absorption studies. To address this, we propose an approach to dose setting for dried residue studies within the current European risk assessment framework. Skin loading for studies can be calculated from the existing exposure algorithms and by taking appropriate body surface areas into account. Thus, skin loading in studies will vary depending on the exact nature and duration of the task and the region of the body exposed, reflecting actual exposure scenarios.
Synergistic antiarrhythmic effect of inward rectifier current inhibition and pulmonary vein isolation in a 3D computer model for atrial fibrillation
Authors: Gharaviri Ali , Pezzuto Simone , Potse Mark , Conte Giulio , Zeemering Stef , Sobota Vladimír , Verheule Sander , Krause Rolf , Auricchio Angelo , Schotten Ulrich 
Published: December 2020

Abstract

Aims
Recent clinical studies showed that antiarrhythmic drug (AAD) treatment and pulmonary vein isolation (PVI) synergistically reduce atrial fibrillation (AF) recurrences after initially successful ablation. Among newly developed atrial-selective AADs, inhibitors of the G-protein-gated acetylcholine-activated inward rectifier current (IKACh) were shown to effectively suppress AF in an experimental model but have not yet been evaluated clinically. We tested in silico whether inhibition of inward rectifier current or its combination with PVI reduces AF inducibility.

Methods and results
We simulated the effect of inward rectifier current blockade (IK blockade), PVI, and their combination on AF inducibility in a detailed three-dimensional model of the human atria with different degrees of fibrosis. IK blockade was simulated with a 30% reduction of its conductivity. Atrial fibrillation was initiated using incremental pacing applied at 20 different locations, in both atria. IK blockade effectively prevented AF induction in simulations without fibrosis as did PVI in simulations without fibrosis and with moderate fibrosis. Both interventions lost their efficacy in severe fibrosis. The combination of IK blockade and PVI prevented AF in simulations without fibrosis, with moderate fibrosis, and even with severe fibrosis. The combined therapy strongly decreased the number of fibrillation waves, due to a synergistic reduction of wavefront generation rate while the wavefront lifespan remained unchanged.

Conclusion
Newly developed blockers of atrial-specific inward rectifier currents, such as IKAch, might prevent AF occurrences and when combined with PVI effectively supress AF recurrences in human.
Strategy for finding occupational health survey participants at risk of long-term sickness absence
Authors: Roelen Corné A M , van Hoffen Marieke F A , Twisk Jos W R , Heymans Martijn W 
Published: December 2020

Abstract

Background
When resources are limited, occupational health survey participants are usually invited to consultations based on an occupational health provider’s subjective considerations. This study aimed to find health survey participants at risk of long-term (i.e., ≥ 42 consecutive days) sickness absence (LTSA) for consultations with occupational health providers (OHPs).

Methods
The data of 64 011 non-sicklisted participants in occupational health surveys between 2010 and 2015 were used for the study. In a random sample of 40 000 participants, 27 survey variables were included in decision tree analysis (DTA) predicting LTSA at 1-year follow-up. The decision tree was transferred into a strategy to find participants for OHP consultations, which was then tested in the remaining 24 011 participants.

Results
In the development sample, 1358 (3.4%) participants had LTSA at 1-year follow-up. DTA produced a decision tree with work ability as first splitting variable; company size and sleep problems were the other splitting variables. A strategy differentiating by company size would find 75% of the LTSA cases in small (≤99 workers) companies and 43% of the LTSA cases in medium-sized (100–499 workers) companies. For large companies (≥500 workers), case-finding was only 25%.

Conclusions
In small and medium-sized companies, work ability and sleep problems can be used to find occupational health survey participants for OHP consultations aimed at preventing LTSA. Research is needed to further develop a case-finding strategy for large companies.
Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality
Authors: McAvay Gail J , Vander Wyk Brent , Allore Heather 
Published: December 2020

AbstractBackgroundMultimorbidity is common in adults aged 65 and older and is associated with health care utilization and mortality, but most methods ignore the interrelationship among concurrent outcome nor provide person-specific probabilities.MethodA longitudinal cohort of 5300 older Americans from the 2011–2015 rounds of the National Health and Aging Study was linked to Center for Medicare and Medicaid Services claims. Odds ratios for 15 chronic conditions adjusted for sociodemographic factors were estimated using a joint model of hospitalization, skilled nursing facility (SNF) admission, and mortality. Additionally, we estimated the person-specific probability of an outcome while currently at risk for other outcomes for different chronic disease combinations demonstrating the heterogeneity across persons with identical chronic conditions.ResultsDuring the 4-year follow-up period, 2867 (54.1%) individuals were hospitalized, 1029 (19.4%) were admitted to a SNF, and 1237 (23.3%) died. Chronic kidney disease, dementia, heart failure, and chronic obstructive pulmonary disease had significant increased odds for all 3 outcomes. By incorporating a person-specific random intercept, there was considerable range of person-specific probabilities for individuals with hypertension, diabetes, and depression with dementia, (hospitalization: 0.14–0.61; SNF admission: 0.04–0.28) and without dementia (hospitalization: 0.07–0.44; SNF admission: 0.02–0.15). Such heterogeneity was found among individuals with heart failure, ischemic heart disease, chronic kidney disease, hypertension, hyperlipidemia, and osteoarthritis with and without Medicare.ConclusionsThis approach of joint modeling of interrelated concurrent health care and mortality outcomes not only provides a cohort-level odds and probabilities but addresses the heterogeneity among otherwise similarly characterized persons identifying those with above-average probability of poor outcomes.
Shear wave velocity model of the Abanico Formation underlying the Santiago City metropolitan area, Chile, using ambient seismic noise tomography
Authors: Salomón J , Pastén C , Ruiz S , Leyton F , Sáez M , Rauld R 
Published: December 2020

SUMMARY
The seismic response of the Santiago City, the capital of Chile with more than 5.5 million inhabitants, is controlled by the properties of the shallower quaternary deposits and the impedance contrast with the underlying Abanico Formation, among other factors. In this study, we process continuous records of ambient seismic noise to perform an ambient seismic noise tomography with the aim of defining the shallower structure of the Abanico Formation underneath the densely populated metropolitan area of Santiago, Chile. The seismic signals were recorded by a network consisting of 29 broad-band seismological stations and 12 accelerograph stations, located in a 35 × 35 km2 quadrant. We used the average coherency of the vertical components to calculate dispersion curves from 0.1 to 5 Hz and Bootstrap resampling to estimate the variance of the traveltimes. The reliable frequency band of the dispersion curves was defined by an empirical method based on sign normalization of the coherency real part. The ambient noise tomography was solved on a domain discretized into 256 2 × 2 km2 cells. Using a regularized weighted least-squares inversion, we inverted the observed traveltimes between stations, assuming straight ray paths, in order to obtain 2-D phase velocity maps from 0.2 to 1.1 Hz, linearly spaced every 0.05 Hz, in 157 of the 256 square cells of the domain. In each square cell with information, dispersion curves were assembled and used to invert shear wave velocity profiles, which were interpolated using the ordinary Kriging method to obtain a 3-D shear wave velocity model valid from 0.6 to 5 km depth. The 3-D velocity model shows that the Abanico Formation is stiffer in the south of the study area with larger velocity anomalies towards the shallower part of the model. The value of the shear wave velocity narrows with depth, reaching an average value of 3.5 km s–1 from 3 to 5 km depth.
Re-assessment of the depth to the base of magnetic sources (DBMS) in Australia from aeromagnetic data using the defractal method
Authors: Kumar Raj , Bansal A R , Betts Peter G , Ravat D 
Published: December 2020

SUMMARY
Australia and North America are the only two continent-wide regions, currently, with the complete wavelength spectrum of magnetic anomalies that can address the much-debated issue of the existence and understanding the magnetic state of the upper mantle. The depth to the base of magnetic sources (DBMS) has been extensively investigated in Australia in previous studies, yielding differing DBMS estimates across the continent. In this contribution, we re-assess the DBMS in Australia from aeromagnetic data using the defractal method, which simultaneously estimates the DBMS and the fractal parameter of the magnetic field. We test the effect of window size on DBMS estimates for the defractal method and conclude that a window size 10 times the expected DBMS is required for the defractal method. We also demonstrate the dependence of derived spectral slopes (and thereby depths) on the size of window by comparing spectral slopes obtained from window sizes up to 1000 km. Our analysis yields DBMS estimates between 25 and 60 km over Australia and are complexly related to temperature structure, magnetic mineralogy and petrology and geological history. Deeper DBMS estimates (∼55–60 km) are obtained for the Yilgarn Craton (West Australian Craton) and the Gawler Craton (South Australian Craton). These estimates are significantly deeper than the Moho, suggesting the uppermost mantle is ferromagnetic for these cold and old cratonic regions. Shallower DBMSs of 25–35 km are obtained in the Pilbara Craton, the eastern and southern part of the Delamerian Orogen, the northwestern part of the Canning Basin, Officer, Cooper and Georgina Basins and the Tasmanides. The areas of shallower DBMS are positively correlated with high heat flow in the regions. On the other hand, regions of large concentrations of radiogenic elements associated with the major metallogenic deposits have high heat flow arising from the radiogenic heat, but deeper DBMSs, for example the eastern margin of the Gawler Craton covered by Neoproterozoic Adelaide Rift Complex, the McArthur Basin, the Pine Creek Inlier.
Generalized score matching for general domains
Authors: Yu Shiqing , Drton Mathias , Shojaie Ali 
Published: December 2020

Abstract
Estimation of density functions supported on general domains arises when the data are naturally restricted to a proper subset of the real space. This problem is complicated by typically intractable normalizing constants. Score matching provides a powerful tool for estimating densities with such intractable normalizing constants but as originally proposed is limited to densities on $\mathbb{R}^m$ and $\mathbb{R}_+^m$. In this paper, we offer a natural generalization of score matching that accommodates densities supported on a very general class of domains. We apply the framework to truncated graphical and pairwise interaction models and provide theoretical guarantees for the resulting estimators. We also generalize a recently proposed method from bounded to unbounded domains and empirically demonstrate the advantages of our method.