bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manejo de Estereotipias en Equinos con Tratamientos a Base de Canabidiol (CBD): Una Revisión Bibliográfica
Authors: Hoyos Vásquez Maria Estefanía , Rivera Herrera Angie Carolina , Restrepo López Mariana 
Published: December 2024

Este artículo de revisión tiene como objetivo sintetizar los hallazgos sobre el uso del cannabidiol (CBD) en el tratamiento de estereotipias en equinos, un problema conductual común asociado al estrés y la ansiedad en estos animales. Se realizó una búsqueda exhaustiva en bases de datos académicas para identificar estudios relevantes sobre el CBD y su impacto en conductas repetitivas. Los estudios seleccionados abarcan investigaciones en equinos y humanos para proporcionar una base comparativa sólida. Los resultados muestran que el CBD actúa principalmente modulando el sistema endocannabinoide, reduciendo la frecuencia e intensidad de estereotipias como el “cribbing”, el “weaving” y el “box walking”, al disminuir los niveles de ansiedad y estrés. Sin embargo, se observan variaciones en la respuesta individual, lo cual sugiere que los tratamientos deben adaptarse según las características de cada equino. A nivel farmacocinético, se determinó que la administración oral de CBD es generalmente segura y bien tolerada en dosis controladas, aunque las dosis más altas pueden producir efectos sedantes leves. En conclusión, aunque el CBD muestra potencial como una herramienta terapéutica para mejorar el bienestar de los equinos, se requiere más investigación para establecer protocolos de dosificación óptimos y específicos para esta especie.
Sistema Didáctico para la Determinación del Número de Reynolds Mediante una Interfaz Gráfica
Authors: Oregan Silva María de Jesús , Martínez Rosales Andrés , Vásquez Jiménez Juan Carlos , Barbosa Contreras Jonathan Esteban , Leal López Luis Antonio 
Published: December 2024

En algunas ingenierías se cursan asignaturas como: termodinámica, análisis de fluidos, estudio de reactores, etc., en donde se tenga que estudiar el comportamiento de determinados fluidos en cuanto al cálculo del número de Reynolds. En este caso considerando en el Instituto Tecnológico de Tehuacán específicamente en la Carrera de Ingeniería Mecatrónica, no se cuenta con un equipo que físico en donde se pueda experimentar el comportamiento de los fluidos. El equipo aporta dos métodos principales de comprobación: el equipo físico por donde se puede apreciar pasar el líquido y la interfaz donde se muestra el número de Reynolds y un puntero dinámico que se mueve a través de una gráfica basada en el diagrama de Moody (Factor de fricción / Número de Reynolds). Se logra obtener un equipo a bajo costo donde los mismos estudiantes de ingeniería podrán operar el equipo y experimentar con los fluidos para estudiar su comportamiento en el régimen laminar, y turbulento, permitiendo la comprobación de los cálculos, el posicionamiento en tiempo real en la gráfica mediante una interfaz gráfica y así arraigar los conocimientos mediante la observación y comprobación de un fluido líquido cercanos a la vida laboral.
Existence of normalized solutions for a Sobolev supercritical Schrödinger equation
Authors: Li Quanqing , Yang Zhipeng 
Published: December 2024

<p>This paper studies the existence of normalized solutions for the following Schrödinger equation with Sobolev supercritical growth:</p><p><disp-formula> <label/> <tex-math id="FE1"> \begin{document}$ \begin{equation*} \begin{cases}	-\Delta u+V(x)u+\lambda u = f(u)+\mu |u|^{p-2}u, \quad &amp;\hbox{in}\;\mathbb{R}^N,\\	\int_{\mathbb{R}^N}|u|^2dx = a^2, \end{cases} \end{equation*} $\end{document} </tex-math></disp-formula></p><p>where $ p &gt; 2^*: = \frac{2N}{N-2} $, $ N\geq 3 $, $ a &gt; 0 $, $ \lambda \in \mathbb{R} $ is an unknown Lagrange multiplier, $ V \in C(\mathbb{R}^N, \mathbb{R}) $, $ f $ satisfies weak mass subcritical conditions. By employing the truncation technique, we establish the existence of normalized solutions to this Sobolev supercritical problem. Our primary contribution lies in our initial exploration of the case $ p &gt; 2^* $, which represents an unfixed frequency problem.</p>
A potential antifungal bioproduct for Microsporum canis: Bee venom
Authors: Ütük Armağan E. , Güven Gökmen Tülin , Yazgan Hatice , Eşki Funda , Turut Nevin , Karahan Şifa , Kıvrak İbrahim , Sevin Sedat , Sezer Osman 
Published: December 2024

Natural treatment options for Microsporum canis dermatophytosis are being explored because of resistance to several antifungal medications. In this study, the potential antifungal effect of bee venom (BV), a natural antimicrobial agent, on M. canis was investigated. The antifungal effects of BV, fluconazole, itraconazole, amphotericin B and terbinafine were evaluated by the macrodilution method at various concentrations by modifying the microdilution method recommended by the European Committee on Antimicrobial Susceptibility Testing. All isolates were observed to be susceptible to terbinafine and fully resistant to fluconazole and amphotericin B. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of M. canis isolate 2 (Mc2) were determined as 8 µg/mL for itraconazole. The MIC and MFC values of BV were found to be 320 µg/mL for the Mc2 isolate and 640 µg/mL for the Mc6 isolate. The results showed that the isolates obtained from clinical samples in this study were highly resistant to all antifungal agents, except terbinafine. The increase in resistance indicates that antifungal drugs will become insufficient and ineffective over time and natural products such as BV should be evaluated as alternatives.Contribution: Although there are many drugs for the treatment of M. canis, the increase in resistance to antifungal agents reveals the need for the identification and development of new natural agents. Bee venom, which has been shown to have a safe and weak allergenic effect in various studies, can be tested for usability as a local antifungal drug when supported by in vivo studies.
Influence of Social Media on Body Image and Eating Disorder Prevalence in Adolescents: A Cross-sectional Saudi Study
Authors: Alzahuf Shuruq , Ahmed Entisar , Al-Badwyi Jumanah Ahmed , Alkhalifa Maryam Abdulhameed , Albinessa Mohammed Ahmed , Bashandi Abdulelah Adel , Alanazi Dimah Mulfi , Alawad Fatema Hani , Alhodibi Mostafa 
Published: December 2024

Abstract

Introduction:
This study delves into the impact of adolescents’ social media interactions with influencers on psychological health, focusing on body image and eating disorders (EDs). It seeks to measure social media’s influence on teenagers and adolescents, its correlation with body image and ED prevalence, aiming to inform future public health strategies.

Methods:
The research, conducted from June and July 2023 in Saudi Arabia, included a diverse group of participants. Data were collected through structured questionnaires and surveys, both online and offline, in various settings. The study aimed to analyse social media exposure, body image perceptions and ED symptoms, using advanced statistical methods.

Results:
With 1884 participants, a significant link was found between social media exposure and body image disturbances, affecting various age groups, particularly females aged late teens to mid-twenties, more so in urban Northern provinces. Engagement with social media influencer content emerged as a key predictor of body image issues and EDs.

Conclusion:
The study offers new perspectives on the psychological effects of social media in the Middle East, underscoring the need for public health interventions. It suggests incorporating social media habits into the clinical management of body image and EDs and calls for re-evaluating public health campaigns to mitigate social media’s negative impact on youth.
Obstetric Analgesia in Saudi Arabia: A Cross-sectional Study of Labour Pain Management Preferences and Satisfaction among Women
Authors: Aleid Abdulsalam Mohammed , Alhajjaj Zahra , Almutlaq Khadijah A. , Almulhim Jawaher E. , Alruwai Fatimah E. , Alenezi Farah B. , Alshammari Amirah M. , Ahmed Rufaida A. 
Published: December 2024

Abstract

Introduction:
Labour pain management is a crucial aspect of obstetrics, significantly impacting the maternal experience during childbirth. Effective analgesia is not only vital for comfort but also influences the overall outcome of labour. This study aims to assess the preferences and satisfaction levels of Saudi Arabian women regarding obstetric analgesia. Despite various pain management methods such as epidural analgesia, there is a notable gap in knowledge and awareness among pregnant women in Saudi Arabia. Understanding these preferences and satisfaction levels is essential for enhancing maternal care and pain management strategies.

Methods:
This cross-sectional study recruited Saudi Arabian women in labour from multiple hospitals across the country. A structured questionnaire, developed specifically for this research, collected data on obstetric analgesia preferences, satisfaction levels and socio-demographic factors. Statistical analysis was conducted using SPSS 28.0, employing correlation analysis, regression analysis and Chi-square tests to examine the relationships between variables and test hypotheses. Categorical variables were characterised using counts and percentages, whereas numerical variables were summarised using descriptive statistics.

Results:
The study found varying levels of awareness and preference regarding obstetric analgesia among Saudi Arabian women. Significant factors influencing these preferences included socio-demographic variables such as income and education levels. The satisfaction levels with different analgesia methods also varied, with epidural analgesia emerging as a preferred option for many participants. These results indicated a need for improved antenatal education and awareness programmes regarding labour pain management options.

Conclusion:
The study highlights the importance of understanding the preferences and satisfaction levels of Saudi Arabian women in labour to provide appropriate pain relief and enhance the overall birthing experience. It underscores the need for comprehensive antenatal care programmes that incorporate education on various labour pain relief methods, particularly epidural analgesia. The findings also suggest tailoring pain management strategies to meet the cultural and individual needs of women in Saudi Arabia, thereby improving maternal care quality and satisfaction during labour.
Prevalence and Risk Factors for Atopic Dermatitis in Saudi Arabian Children: A Cross-sectional Study
Authors: Aleid Ali M. , Alkhunaizi Lama Tariq , Alzahran Marwan Sameer , Alruwaili Maram Shafi , Alshammari Haifa Hijji , Alhajri Fatimah Salah , Alshammari Ibtihal Saqr , Alsaeed Anwar Mustafa 
Published: December 2024

Abstract

Background:
Atopic dermatitis (AD) is an inflammatory skin disease of cyclical nature, which is rather significant for several aspects of children’s health. Therefore, the aim of the present study was to determine the prevalence of AD among the Saudi Arabian children and few predisposing factors associated with the disease.

Methods:
A cross-sectional survey method was used, and the data were obtained with the help of an online self-administered questionnaire that was shared with parents or guardians of children in Saudi Arabia. Gathered data included demographic data, presence of AD markers and history, other risk factors, coexisting diseases, perceived satisfaction with treatment and the disease severity. The analysis of data was done by the use of Statistical Product and Service Solutions (SPSS) 28. Continuous data were compared to AD prevalence using t-tests, whereas categorical variables were compared to AD prevalence using Chi-square tests.

Results:
AD in the population was present at a frequency of 66.7% (n = 2400), with the majority of children being diagnosed at the age of 1–3 years (28.4%). Most of the patients were mildly to moderately irritated (36.3% and 49.2%, respectively) and had occasional flare-ups. The bold risk factors identified were maternal antecedent AD (4.9%), never breastfed (33.3%), and exposure to allergens. As for the most frequent comorbid diseases, the respondents reported their experience of having asthma (21.6%) and allergic rhinitis (28.4%). Two chronic signs were noted in some patients: constant itching and disturbance of sleep, which affected 9% of cases. These complaints impacted the patient’s functioning in 34% of cases. Three per cent of children. Satisfaction with the treatment per se was moderate but not of the optimum magnitude, 40. Despite the high level of very satisfaction with the treatment reported by about 2% of the families, the treatment remained costly to the families, with some 2. Only 9% of the respondents said that they endured ‘constant’ financial distress because of the condition.

Conclusion:
AD has become a significant health issue affecting children in Saudi Arabia. Several important risk factors have been identified, which may aid in the early detection and control of the condition. These outcomes describe the progression of allergic reactions as elevated and emphasise the need for integrated care models because people with allergies are most commonly affected by two or more varieties of allergies simultaneously. Further literature studies were needed to examine the immunological aspects and improve the details of this disease’s courses that would enhance the lives of children.
A Comprehensive Systematic Review and Meta-analysis on the Efficacy of Rehabilitations in Colorectal Cancer Surgery for Improved Functional Capacity
Authors: Alessa Nujud , Alshehri Renad Mohammed , Banser Sultan , Mohammed Ruba , Almonawar Alhassan , Aljefri Shatha , AlHarbi Nada Sulaiman , Hakme Elie 
Published: December 2024

Abstract

Background:
Colorectal cancer (CRC) surgery often results in a decline in functional capacity, impacting patients’ post-operative recovery. This systematic review and meta-analysis aimed to evaluate the effectiveness of rehabilitations in enhancing functional outcomes for individuals undergoing CRC surgery.

Materials and Methods:
Randomised controlled trials exploring prehabilitation effectiveness for functional capacity in CRC surgery patients were included in the study. Studies published until March 2024 were identified from PubMed, Web of Science and Cochrane Library. Methodological quality was assessed using the risk of bias-1 tool. Statistical analysis involved calculating the mean difference (MD) and corresponding 95% confidence intervals (CIs) using Review Manager 5.4.1.

Results:
The systematic review included five studies involving 661 CRC patients. Prehabilitation led to a substantial improvement in functional capacity (MD = 18.25, 95% CI: −1.17–37.67; P = 0.07).

Conclusions:
The review and meta-analysis suggest that rehabilitation enhances functional ability post- CRC surgery, potentially reducing post-operative deterioration. Clinicians and health care regulators should consider incorporating rehabilitation into normal care for CRC patients, but further research is needed to improve rehabilitation procedures and long-term functional recovery effects.
A Systematic Review and Meta-analysis Comparing the Effect of Unilateral versus Bilateral Cochlear Implant in Hearing Impairment
Authors: Alshahrani Najla Ali , AlSufyani Naif Hamoud , Aldawish Reema Abdullah , Alrashdi Atheer Khalid , Moafa Razan Hamoud , Alqahtani Maisa Abdullah N. , Aljabri Ahmed Mohammed , Alawad Fatema Hani , Alarfaj Abdullah Ahmed 
Published: December 2024

Abstract

Background:
The aim of this systematic review and meta-analysis was to investigate concerning language shifts, cognitive shifts, and SiN sensitivity in children with severe to profound auditive impairments by using unilateral or bilateral CI. Hearing and speech are incredibly important for language acquisition and neurocognitive development, and CI’s are designed to reverse the effects of hearing loss. Participants were divided into two groups: Comparisons have been made between the early and older CI users and normal hearing children and between unilateral and bilateral CI users.

Methods:
As per PRISMA and Cochrane guideline, an electronic search was done in PubMed, Web of Science and scopus. Out of 274 articles initially identified, we compared 8 cohort studies.

Results:
The meta-analysis revealed that bilateral CI provided superior speech perception compared to unilateral CI, with a mean difference of −0.41 (95% CI: The correlations for each group were as follows: healthy controls, r = −0.62, P < 0.0001; patients with PD, r = 0.21, P < 0.0001.Low-frequency BWSTC for patients with PD (n = 164) was also found to be significantly higher than that of healthy controls (n = 83) [mean difference, 0.62; 95%.

Conclusions:
These results provide support for the activation and use of bilateral cochlear implants and CI recipients’ auditory and communicative advancements. However, the outcomes for these children may be modified by individual medical and social factors. These observations call for further work employing psychometric instruments in order to sharpen them.
Efficacy of Olanzapine in Enhancing Cognitive Functions in Psychiatric Disorders: A Systematic Review and Meta-analysis
Authors: Alotaibi Rana Abdulmohsen , Alshahrani Salma Sultan , Alhajri Abdullah Mutrik , Alqahtani Dina Fares , Alharthi Abdulaziz Matar , Alsubaie Albandari Thawab , Hajwal Rawan Hussain , Alshehri Amal Ali , Alawad Fatema Hani , Alhodibi Mostafa Habeeb 
Published: December 2024

Abstract

Background:
Psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder significantly impair cognitive functions, impacting patients’ functional outcomes. While antipsychotic medications such as Olanzapine are recognised for their efficacy in symptom management, emerging evidence suggests their potential role in cognitive enhancement.

Aim:
This systematic review and meta-analysis aim to evaluate the efficacy of Olanzapine in improving cognitive functions among patients with psychiatric disorders, particularly focusing on schizophrenia.

Methods:
Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines, a comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and the Cochrane library. The search focused on randomised controlled trials and cohort studies published in English that assessed the cognitive effects of Olanzapine.

Results:
In our analysis of 15 studies with 1192 patients, Olanzapine showed significant cognitive improvements. Verbal Learning exhibited a significant increase with an standardised mean difference (SMD) of 0.75 (95% confidence interval [CI] [0.36, 1.14]). Verbal fluency enhancements were observed with an SMD of 0.20 (95% CI [0.03, 0.37]). Executive function, measured by Trails B, improved with an SMD of −0.32 (95% CI [−0.46, −0.18]) and Attention and Processing Speed show a statistically significant increase with an SMD of 0.48 (95% CI [0.05, 0.91]). Immediate memory recall improved with an SMD of 0.65 (95% CI [0.45, 0.85]) and delayed memory recall with an SMD of 0.25 (95% CI [0.12, 0.39]). However, Working Memory showed no significant effect (SMD = −0.01, 95% CI [−0.21, 0.20]) and Positive and Negative Syndrome Scale scores did not indicate significant change (SMD = −0.41, 95% CI [−1.48, 2.31]).

Conclusion:
This meta-analysis demonstrates that olanzapine significantly enhances cognitive functions such as verbal learning, fluency, executive function, attention and memory in psychiatric patients, with domain-specific benefits and no significant impact on working memory or overall psychiatric symptoms. These findings support Olanzapine’s role in comprehensive treatment strategies for cognitive improvement in psychiatric disorders, highlighting the need for personalised approaches to maximise its cognitive benefits.
Sedentary Lifestyle and Dietary Habits as Predictors of Metabolic Syndrome amongst Middle-aged Adults: A Cross-sectional Analysis
Authors: Alkathem Jafar Ali , Almousa Wala’a Hussain , Alanazi Abdulrahman Munnef , AlQurain Zainabza Jasim , Almushageh Mohammed Bader , Al Mohaini Mohammad 
Published: December 2024

Abstract

Introduction:
The metabolic syndrome characterised by obesity, dyslipidaemia, hypertension and hyperglycaemia increases risk factors for cardiovascular diseases and diabetes. The purpose of this study is to ascertain the effect of sedentary behaviour and diet in the prevalence of metabolic syndrome in middle-aged adults.

Methods:
Data collection was done using an online survey amongst 624 Saudi adults aged between 18 and 54 years. Sedentary behaviour and dietary patterns were measured, and metabolic syndrome was defined by two or more of the following: high waist circumference and high blood pressure.

Results:
Physical inactivity was evident, with 41% of the participants having metabolic syndrome. The results also revealed that the odds of having metabolic syndrome raised to 2 if one spends over 6 h per day sedentary. Threefold (95% confidence interval 1. 3, 3 times, P = 0. 04) as compared to infrequent consumers of sugary beverages, the risk of having the disease was increased by 1.

Conclusion:
Physical inactivities and wrong dietary patterns greatly increase one’s chances of developing metabolic syndrome. Encouraging exercise and proper diets may help to alleviate this burden in middle-aged individuals.