bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors Analysis and Nomogram Development for Pancreatic Pseudocyst in Idiopathic Chronic Pancreatitis
Authors: Liu Yu , Wang Dan , Hao Lu , Wang Teng , Zhang Di , Yang Huai-Yu , Ma Jia-Yi , Li Juan , Zhang Ling-Ling , Lin Kun , Chen Cui , Guo Hong-Lei , Bi Ya-Wei , Xin Lei , Zeng Xiang-Peng , Chen Hui , Xie Ting , Liao Zhuan , Cong Zhi-Jie , Li Zhao-Shen , Hu Liang-Hao 
Published: July 2020

Objective
The study concerns identifying risk factors and developing nomogram for pancreatic pseudocyst (PPC) in idiopathic chronic pancreatitis (ICP) to facilitate early diagnosis.

Methods
From January 2000 to December 2013, ICP patients admitted to our center were enrolled. Cumulative incidence of PPC was determined by Kaplan-Meier method. Patients were randomized into training group and validation group in a 2:1 ratio. Risk factors of PPC were determined through Cox proportional hazards regression model based on training cohort. The nomogram was constructed according to risk factors.

Results
Totally, 1633 ICP patients were included with a median follow-up duration of 9.8 years. Pancreatic pseudocyst was observed in 14.7% (240/1633) of patients after ICP onset. The cumulative incidences of PPC were 8.2%, 10.4%, and 12.9% at 3, 5, and 10 years after ICP onset, respectively. Male sex, smoking history, history of severe acute pancreatitis, and chronic pain at/before diagnosis of ICP and complex pathologic changes in main pancreatic duct were recognized as risk factors of PPC development. The nomogram constructed with these risk factors achieved good concordance indexes.

Conclusions
Risk for PPC could be estimated through the nomogram. High-risk patients were suggested to be followed up closely to help early diagnosis of PPC.
Different Hospital Readmissions and Outcomes of Acute Pancreatitis
Authors: Adejumo Adeyinka Charles , Pani Lydie 
Published: July 2020

Objectives
Although acute pancreatitis (AP) is associated with recurrent hospitalizations, the impact of different hospital readmissions (DHR) versus same hospital readmissions (SHR) on outcomes is unknown. We study the burden of DHR among readmissions after survival from AP hospitalizations.

Methods
Among adult AP patients (Nationwide Readmissions Database), we calculated the prevalence, trends, and predictors of DHR, and its impact on mortality, hospital stay, and charges during 30- and 90-day readmissions.

Results
From 2010 to 2014, 15% and 26% of AP hospitalizations (422,950) were readmitted in 30 and 90 days, respectively. The DHR rates were similar (26.3%, 30 days; 26.4%, 90 days) and unchanged from 2010 to 2014 (P
trends > 0.10). The predictors of DHR were similar during both readmissions and included younger age category (18–45 years), hospital characteristics (nonteaching, small bed size, nonmicropolitan/metropolitan areas), substance abuse, comorbidities, and nonreception of cholecystectomy and pancreatectomy during index hospitalizations.
During readmissions (30 and 90 days), DHR was associated with adjusted odds ratio (95% confidence interval), higher mortality (1.40 [1.19–1.64] and 1.50 [1.32–1.71]), longer hospital stay (1.3 days [1.1–1.7 days] and 1.1 days [0.9–1.3 days]), and higher charges (US $16,779 [US $13,898–US $20,254] and US $14,299 [US $12,299–US $16,623]).

Conclusions
Targeted measures are needed toward patients at risk for DHR to curb the poor outcomes.
Complex Genetics in Pancreatitis
Authors: Ellison Mitchell A. , Spagnolo Daniel M. , Shelton Celeste , Orlova Ekatarina , LaRusch Jessica , Whitcomb David C. , Haupt Mark 
Published: July 2020

Objectives
Chronic pancreatitis is the end stage of a pathologic inflammatory syndrome with multiple etiological factors, including genetic. We hypothesized that some pancreatitis etiology originates in pancreatic acinar or duct cells and requires both injury and compensatory mechanism failure.

Methods
One hundred pancreatitis patients were assessed using a DNA sequencing panel for pancreatitis. Cooccurrence of variants within and between genes was measured. Gene coexpression was confirmed via published single-cell RNA sequencing.

Results
One hundred and twenty-one variants were identified in 2 or more patients, 15 of which were enriched compared with reference populations. Single cell RNA-sequencing data verified coexpression of GGT1, CFTR, and PRSS1 in duct cells, PRSS1, CPA1, CEL, CTRC, and SPINK1 in acinar cells, and UBR1 in both. Multiple-risk variants with injury/stress effects (CEL, CFTR, CPA1, PRSS1) and impaired cell protection (CTRC, GGT1, SPINK1, UBR1) cooccur within duct cells, acinar cells, or both.

Conclusions
Pancreatitis is a complex disorder with genetic interactions across genes and cell types. These findings suggest a new, non-Mendelian genetic risk/etiology paradigm where a combination of nonpathogenic genetic risk variants in groups of susceptibility genes and injury/dysfunction response genes contribute to acquired pancreatic disease.
An Integrative Review on Factors Contributing to Fear of Cancer Recurrence Among Young Adult Breast Cancer Survivors
Authors: Gormley Maurade , Ghazal Lauren , Fu Mei R. , Van Cleave Janet H. , Knobf Tish , Hammer Marilyn 
Published: July 2020

Background
Fear of cancer recurrence (FCR) is the most prevalent need among breast cancer survivors. Age is the most consistent predictor of higher FCR, with prevalence rates as high as 70% among young adults. Although the association between age and higher FCR is well established, a more comprehensive understanding of the factors contributing to higher FCR among young adult breast cancer survivors is needed.

Objective
The purpose of this integrative review was to explore the factors associated with higher FCR among young adult breast cancer survivors (≤ 45 years old).

Methods
A literature search was conducted using PubMed, CINAHL, PsycINFO, and EMBASE databases with specific Medical Subject Headings terms delimited to FCR, diagnosis, sex, and age range. The initial search yielded 378 studies, 13 of which met the eligibility criteria.

Results
Themes include motherhood status, health behaviors and decision making (eg, surveillance behaviors and surgical decision making), psychological morbidity, and social support. Cognitive behavioral factors include cognitive processing, metacognition, illness intrusiveness, and self-efficacy.

Conclusion
Fear of cancer recurrence among young adult breast cancer survivors is a unique construct requiring further exploration and tailored interventions to improve the health-related quality of life for this population.

Implications for Practice
Oncology nurses should screen all cancer survivors for FCR, with particular attention to the unique needs of young adults. Future research should address the role of age-appropriate support and increased levels of FCR during surveillance periods.
Keeping Patients Under the Damage Threshold for Pressure Injury
Authors: Tanner Laurel , Rappl Laurie , Oberg Craig , Call Evan 
Published: July 2020

Background:
Pressure injuries (PI) are an ongoing problem in health care. Current interventions, both from clinicians and support surface technologies, do not sufficiently address PI prevention.

Problem:
Patient microclimate is a contributing risk factor for PI, one which can be more adequately addressed. However, the acceptable range for microclimate is unknown, in part because the body adapts to changing conditions.

Approach:
Two key concepts in allostasis are finite resources and responding to intrinsic and extrinsic demands. These concepts have not previously been applied to PI treatment or interventions. Addressing microclimate, when coupled with an increasing awareness of the cumulative effect of individual patient risk factors, can help resolve the risk of PI by lowering the cumulative inputs to keep patients under the threshold for tissue damage.

Conclusion:
This new approach, which places microclimate risk into the broader conceptual framework of allostasis, can produce more effective products and interventions to prevent PI.
Improving Sleep Disturbance in Hospitalized Dementia Patients
Authors: Haffner Susan Townsend , Bjorklund Pamela 
Published: July 2020

Problem:
Sleep disturbance is common in hospitalized dementia patients. Consequences include adverse health outcomes and heavy social and economic costs. Education programs have improved dementia care and outcomes.

Aims:
A quality improvement project designed to improve sleep disturbance in hospitalized dementia patients was piloted on a medical-surgical unit of an urban, Midwestern hospital.

Methods:
Nurses and nursing assistants received education on evidence-based interventions to improve sleep disturbance in dementia patients. Pre-/posttests measured changes in staff knowledge. Sleep logs measured changes in hours of patient sleep.

Results:
Mean test scores increased for nurses from pre- to posttest. Sleep-wake tracking showed increased hours of sleep over time, but small sample sizes precluded pre- and posteducation statistical comparisons.

Conclusions:
Education programs can increase nurses' knowledge of evidence-based sleep disturbance care for dementia patients. Larger sample sizes are needed to determine whether such programs can significantly improve their sleep.
Experience of an 8-Week Online Mindfulness Intervention for Nursing Students
Authors: Spadaro Kathleen C. , Hunker Diane F. 
Published: July 2020

Background
Nurses returning to school often have stressors of work, family, and other obligations. Strategies are needed to mitigate the additional stress and promote academic success. Mindfulness is one proposed strategy.

Purpose
The purpose was to explore the experience of students participating in an 8-week mindfulness intervention.

Methods
A mixed-methods descriptive study used an emailed survey link with 13 open-ended questions at intervention completion. Interpretive description guided the qualitative analysis. Participant retention, reported practice frequency, and written feedback were analyzed for feasibility and acceptability.

Results
Twenty-six participants completed the survey. Time commitment, increased awareness, focus and concentration, and enhanced coping were identified themes. Findings supported the impact of mindfulness on student stress, anxiety and cognition, as well as acceptability and feasibility.

Conclusions
An online mindfulness program appeared effective, feasible, and acceptable. Qualitative findings informed the quantitative outcomes. Nursing faculty can impact student stress and academic success through mindfulness with their teaching.
Evaluating Scientific Writing Skill in DNP Program Students
Authors: DeCoux Hampton Michelle , Chafetz Linda 
Published: July 2020

Background/Problem
Scientific writing skill development interventions in nursing are widely represented in the literature, but the specific skills required are poorly defined and measured.

Approach
This study used a cross-sectional, descriptive design to compare scientific writing skill assessment of doctor of nursing practice students' final project reports using 2 rubrics.

Outcomes
Of 13 skills, the strongest were: adherence to a standard structure, paraphrasing, and grammar, punctuation, and style. The weakest were: use of primary sources, concise, nonredundant presentation, and critical appraisal. Overall interrater agreement for the general essay writing rubric was 69.6%, and that for the scientific writing rubric was 82.3%.

Conclusions
Compared to the essay rubric, the scientific writing rubric was more useful for identifying skill strengths and weaknesses and improved interrater consistency.
Effects of Knowledge and Value on Quality of Supportive Peer Feedback
Authors: Tornwall Joni , Xie Kui , Yu Shirley L. , Stein David , Zurmehly Joyce , Nichols Robert 
Published: July 2020

Background
Motivational barriers and lack of knowledge about peer review inhibit creation of supportive peer feedback between nursing students.

Purpose
The purpose of this study was to examine the effects of knowledge of peer-review practices and value for the process of creating supportive peer feedback on the quality of feedback nursing students create for their peers.

Method
Data from 155 graduate nursing students were analyzed in this quasi-experimental, repeated-measures design, using analysis of covariance and conditional process analysis.

Results
Students who had high levels of knowledge and a strong sense of value for providing feedback to peers produced higher-quality supportive peer feedback.

Conclusion
Even when a student has sufficient knowledge and skills to produce supportive peer feedback, their ability may not transfer to real peer-review contexts if they do not also have a strong sense of value for providing high-quality feedback to peers.
Interhospital Transport of Children With Peripheral Venous Catheters by Private Vehicle: A Mixed Methods Assessment
Authors: Mangus Courtney W. , Canares Therese , Klein Bruce L. , Costabile Philomena , Monroe David , Noje Corina , Stevens Martha W. 
Published: July 2020

Background
Many children seeking emergency care at community hospitals require transport to tertiary centers for definitive management. Interhospital transport via ambulance versus patient's own vehicle (POV) are 2 possible modes of transport; however, presence of a peripheral venous catheter (PIV) can determine transport by ambulance. Caregiver satisfaction, patient comfort, and PIV complications related to POV transport have not been described.

Objective
The aims of the study were to examine caregivers' satisfaction and perceptions of POV transport in children with/without PIVs and to assess PIV-related complications during transport.

Methods
We performed a mixed-methods, prospective cohort study of children who presented with low-acuity conditions to a community hospital and subsequently required transfer to a pediatric tertiary center. Caregivers of patients with/without PIVs were given the choice of transport by POV or ambulance. Surveys completed after transport used dichotomous, 5-point Likert scale, and open-ended responses to assess satisfaction, perceptions, and PIV-related complications. Responses were quantitatively and qualitatively analyzed accordingly. The receiving hospital assessed PIV integrity.

Results
Sixty-nine of 78 eligible patients were enrolled; of those, 67 (97%) elected transport by POV and 55 (82%) completed surveys. Most caregivers had positive responses related to satisfaction, comfort, and safety. Results did not differ significantly between those with/without PIVs. The majority (96%) would choose POV transport again. There were no reported PIV complications; all PIVs were functional upon arrival. Qualitative analysis identified themes of comfort, convenience, and efficiency.

Conclusions
In select scenarios, interfacility transport by POV is preferred by families and doing so with a saline-locked PIV does not result in complications.
Identifying Risk Factors for Elbow Injury in Children Presenting to the Emergency Department With Distal Forearm Fractures
Authors: Rubinstein Max , Hirway Priya , Zonfrillo Mark R. 
Published: July 2020

Background
Pediatric distal forearm fractures are one of the most common injuries seen in the emergency department. Orthopedic teaching instructs providers to radiograph the joint above and the joint below the fracture site for concurrent injury. Despite this teaching, there is little evidence to suggest that elbow injuries are common in children with distal forearm fractures. Similarly, there are few data that help the clinician predict which children are at higher risk for co-injury.

Methods
We conducted a cross-sectional analysis of the 2011 National Emergency Department Sample data set. Children aged 2 to 17 years with an International Classification of Disease, Ninth Revision, code for a distal forearm fracture were included in the study. The primary outcome of interest was an “elbow” injury, defined as an International Classification of Disease, Ninth Revision, code for proximal radius, proximal ulna, or distal humeral fracture or dislocation. Multivariable logistic regression was performed using patient demographics, injury severity score, mechanism of injury, and underlying medical conditions.

Results
A total of 54,262 children with a distal forearm fracture were identified. Of these children, only 0.8% (n = 463) had an elbow injury. Supracondylar fractures of the humerus were the most common elbow injury seen (48.2% of elbow injuries seen). Children were more likely to have a co-injury if they were younger (9.8 years vs 8.3 years, P < 0.01), female (36% vs 44%, P < 0.01), injured via fall (68% vs 76%, P < 0.01), had a higher injury severity score (4.1 vs 4.5, P < 0.01), or were admitted for their injuries (1.5% vs 15.7%, P < 0.01). In the adjusted model, only age and disposition were predictors of co-injury. Isolated buckle fracture of the radius and metaphyseal fracture of the radius with dorsal angulation were protective against elbow injury (odds ratio = 0.39 and 0.60, respectively).

Conclusions
Children with distal forearm fractures very rarely have concurrent elbow injuries. These injuries are more likely in younger female children.
Variation in the Presentation of Intussusception by Age
Authors: Kimia Amir A. , Hadar Peter N. , Williams Scotty , Landschaft Assaf , Monuteaux Michael C. , Bachur Richard G. 
Published: July 2020

ObjectiveTo compare the clinical presentation of intussusception among children younger and older than 24 months of age.Design/MethodsWe performed a retrospective cross-sectional cohort study of children treated in the emergency department, aged 1 month to 6 years, who had an abdominal ultrasound to evaluate for intussusception over a 5-year period. After stratifying by an age cut-point of 24 months, univariate and multivariate analyses were performed.ResultsOne thousand two hundred fifty-eight cases of suspected intussusception were studied; median age was 1.7 years (interquartile range, 0.8, 2.9 years), and 37% were female. Intussusception was identified in 176 children (14%); 153 (87%) were ileocolic, and 23 were ileoileal. Abdominal pain (odds ratio, 4.0; 95% confidence interval [CI], 1.5–10.5), emesis (OR, 3.5; 95% CI, 1.8–6.7), bilious emesis (OR, 2.9; 95% CI, 1.5–5.7), lethargy (OR, 2.3; 95% CI, 1.3–5.7), rectal bleeding (OR, 2.8; 95% CI, 1.4–5.7), and irritability (OR, 0.4; 95% CI, 0.2–0.8) were found to be predictors in those younger than 24 months. In children older than 24 months, male sex was the only predictor identified (OR, 2.0; 95% CI, 1.1–3.7). In cases where abdominal radiographs were obtained (n = 1212), any abnormality on abdominal radiograph was found to be predictive in both age groups (OR, 7.8; 95% CI, 3.8–25.7; and OR, 3.1; 95% CI, 1.8–5.2, respectively).ConclusionsIntussusception presents differently in children younger than 24 months compared with older children. “Traditional” clinical predictors of intussusception should be interpreted with caution when assessing children older than 2 years.
Clinical Evaluation of Scar Quality Following the Use of Prophylactic Negative Pressure Wound Therapy in Obese Women Undergoing Cesarean Delivery
Authors: Hyldig Nana , Möller Sören , Joergensen Jan Stener , Bille Camilla 
Published: July 2020

Objective
To evaluate the cosmetic result of using incisional negative-pressure wound therapy (iNPWT) compared with standard postsurgical dressings in obese women undergoing cesarean delivery (CD).

Methods
Postcesarean scars were objectively evaluated 6 and 12 months postsurgery by a plastic surgeon using the Manchester Scar Scale and the Stony Brook Scar Evaluation Scale. Subjective scar evaluation and health-related quality of life were assessed using the Patient Scar Assessment Scale and the EQ-5D-5L instrument, respectively. Main outcome measures were the cosmetic and functional outcome of treating a standardized surgical wound with iNPWT compared with standard dressings, changes in scar rating over time, and testing different scar scales for cosmetic evaluation.

Results
The study found no difference in long-term cosmetic outcomes between iNPWT and standard dressings. The study demonstrated a statistically significant positive change in scar rating from surgery to 12 months postsurgery. A strong association was found between the scar scales with a high correlation between the objective scar scales (R approximately 0.80) and a moderate correlation between the subjective scale and each objective scale (R approximately 0.50).

Conclusions
Prophylactic iNPWT has been found to reduce the risk of surgical site infection following CD. Conversely, this study was not able to detect a difference in the long-term cosmetic result after CD when compared with standard dressings.
Attachment-Oriented Endoscopic Treatment of Inverted Papilloma Involving the Frontal Sinus/Recess
Authors: Wang Yanjie , An Yunfang , Zhao Changqing , Dong Rui , Cheng Fengli 
Published: July 2020

Purpose:
Sinonasal inverted papilloma (IP) is a benign but locally aggressive tumor for which an endoscopic or external surgical approach is the treatment of choice. Complete resection of IP involving the frontal sinus/recess forms one of the most challenging procedures in the field of sinonasal surgery. This study aims to present our experience in the management of extensive frontal sinus IP based on the attachment sites of the tumor.

Methods:
Thirteen patients with IP involving the frontal sinus/recess between 2010 and 2018 were presented. The data collected include demographic data, tumor attachment sites, tumor extension, tumor staging according to Meng's staging system, surgical approach, recurrence, and follow-up.

Results:
The patients were successfully treated by endoscopic surgery without any additional external approaches. The attachment sites of the IP were multifocal in some patients. No recurrence was identified after an average follow-up period of 52.88 months. No major intra- or postoperative complications were observed.

Conclusion:
The present study shows that attachment-oriented excision for IP involving the frontal sinus/recess is an acceptable approach. Surgeons should select the surgical approach based on the attachment sites of the tumor rather than the extension of the tumor. Even more importantly, the tumor attachment sites should include the sites of adhesion to the bone wall and the site of origin.