bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Assimilation of TRIZ in Dissecting the Statistical Outcomes of Tactile Sensitivity, Pinch Force and Endurance among Elderly People
Authors: Tan Dominic Wen How , Ng Poh Kiat , Noor Ervina Efzan Mhd 
Published: January 2020

Abstract
Background: Numerous investigations have analysed the handgrip force and endurance of elderly people. However, few studies examine reduced and increased tactile sensibility effects on the pinch force and endurance of elderly people. Even fewer studies include the problem-solving process extending from statistical outcomes of such studies. This study examines tactile sensibility effects on the pinch force and endurance of elderly people, and potentially resolves issues dissected from these inferences using TRIZ. Methods: Data on pinch force and endurance time was collected among 32 subjects aged 55-65 years old. Subjects were required to pinch an experimental apparatus at their maximum limit, and sustain their pinching activity for as long as possible. Cotton gloves were for reduced tactile sensibility while rubber gloves were for increased tactile sensibility. The two-sample T-test results were further analysed using TRIZ.Results: The results suggested that a significant difference existed between the pinch force from reduced and increased tactile sensibility (p < 0.05), with similar outcomes for endurance time. Resolving TRIZ contradictions identified from the results presented this study with a principle known as “partial action”, which suggested that elderly people should pinch using less of the originally desired force when the exact intended force is difficult to achieve, rather than exerting a high pinch force in a single attempt. The “segmentation” and “other way around” principles were also recommended. Through Su-Field analysis, it was found that harmful effects from pinching can be neutralised using intermediary materials between the fingers and object, such as rubber. The analysis also proposed using optical or acoustic fields, whereby light sensors or buzzers could act as mechanisms to provide signals once a sufficient pinch force is detected. Conclusion: This study confirmed that elderlies with poor tactile sensibility commonly pinch objects with excessive force and extended durations. The inventive solutions that extend from this finding through TRIZ provide new insights to researchers in product design with the aim of resolving poor pinch performance caused by degrading tactile sensibility.
Bioinformatics for differential proteomics data between triple-negative breast cancer and luminal A subtype breast cancer
Authors: wu guogang , Zhang Lei , Liang Chunyan , Cheng Yao , Lv Chenguang , Chen Bo 
Published: January 2020

Abstract
Background The heterogeneity between different subtypes of breast cancer has been established. Triple-negative breast cancer (TNBC) is the type of breast cancer with the highest recurrence rate, metastasis rate, and worst prognosis, while luminal A breast cancer is the subtype with the best prognosis. To study the heterogeneity of the two subtypes of breast cancer is important. Methods We adopted a quantitative proteomics detection method based on data-independent acquisition and screened all differentially proteins between TNBC and luminal A breast cancer. Ingenuity Pathways Analysis was used for analysis. Results We found that 207 proteins were up-regulated and 326 proteins were down-regulated. Classical pathway analysis showed that Eukaryotic translation initiation factor 2 (EIF2) signaling was significantly activated, in which EIF2α and other molecules were significantly up-regulated. The upstream regulatory analysis predicted 18 strong activators and 63 strong inhibitors, among which v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) was the strongest activator and tretinoin was the strongest inhibitor. Based on disease and function analysis, it was found that differentially proteins were enriched in 41 biological processes, with RNA damage and repair and protein synthesis the most significant biological processes. There were 14 diseases or functions that were significantly activated and 35 that were significantly suppressed. Among the diseases or functions, the differentially proteins had the most significant inhibitory effect on osteosarcoma cell death. According to an analysis of the interaction network, 25 molecular interaction networks were found and the network with the highest score mainly affected the diseases and functions of cancer, protein synthesis, and RNA damage and repair. Conclusion We identified many key proteins with TNBC heterogeneous characteristics and differentially expression, which will provide an abundance of new information for screening TNBC therapeutic specific targets and biomarkers.
Effectiveness and Safety of Surgical Interventions for Treating Adolescent Idiopathic Scoliosis: a Bayesian Meta-analysis
Authors: Chen Long , Sun Zeyu , He Jingming , Xu Yunwen , Li Zhuhai , Zou Qian , Li Bo 
Published: January 2020

Abstract
Background Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity in children and adolescents which presents as complex three-dimensional (3D) deformity of the spine and rib cage. This study aimed to estimate the effectiveness and safety of surgical interventions for AIS using Bayesian meta-analysis.Methods The PubMed, EMBASE, and Cochrane Controlled Register of Trials were searched through Oct 1, 2019, without language restrictions. Relevant studies evaluating combined effectiveness and safety of surgical interventions for AIS were included according to eligibility criteria. The primary outcome measures included pulmonary function (change of absolute forced vital capacity and forced expiratory volume in one second from pre-operation to post-operation) and incidence of complications. The secondary outcome measure was change of Cobb angle from pre-operation to post-operation. Data was pooled using a random effects model in pairwise meta-analysis. Bayesian meta-analysis combined direct and indirect evidence using a Bayesian framework.Results 28 case-controlled studies with totally 1970 participants were included. This Bayesian meta-analysis combining direct and indirect evidences indicated that posterior fusion with instrumentation without thoracoplasty (PSF) had the highest probability to achieve better pulmonary function and lower complication rate; video assisted anterior fusion with instrumentation without thoracoplasty (VAT) had the highest probability to obtain better Cobb angle correction based on analysis of rank probability.Conclusion This Bayesian meta-analysis gives a practical recommendation of PSF as a primary surgical treatment for AIS. The results also support statistics that current surgeries adopted more PSF but less open anterior approach surgery and thoracoplasty. More research work is required to address the effectiveness and safety of VAT for treating AIS more convincingly.
Audiovisual integrative training for augmenting cognitive- motor functions in older adults with mild cognitive impairment
Authors: Lee Leung- Pong , Har Afifah Wing- Yiu , Ngai Chun- Hei , Lai Daniel W.L. , Lam Bess Yin Hung , Chan Chetwyn Che-Hin 
Published: January 2020

Abstract
Background: Previous studies indicated that the behavioral performances of older adults could be enhanced by multisensory integration. This pilot study tested the benefits of an audiovisual integrative (AV) training for improving the cognitive and upper limb motor functions in older adults with mild cognitive impairment (MCI).Methods: Twenty participants, according to their MoCA scores, with ten in each of a MCI (mean age= 63.3 years) and healthy older adult group (mean age= 64.7 years), engaged in AV integrative training. They were recruited from the Institute of Active Ageing at the Hong Kong Polytechnic University. The screening was conducted from February to March 2018 and the training program which consisted of three sessions (2 hours each) was conducted from 14-28th May 2018. Their executive function, attention and upper limb functions were measured by the Stroop Test and Purdue Pegboard Test respectively.Results: The mixed linear model analysis results showed significant Time x Group interaction effects in the time used in the Stroop Test (dots) (p = 0.042) and the Purdue Pegboard scores (non-dominant hand use) (p = 0.025). The MCI group exhibited significantly more improvements in attentional control and non-dominant hand motor functions after the training.Conclusions: The findings suggest that the AV integrative training has the potential for enhancing the cognitive and motor functions of older adults with MCI. Furthermore, AV integrative training can serve as an alternative non-pharmacological intervention for combating neurodegeneration in older adults.
Effect of Resilience on Infertile Couples’ Quality of Life: An Actor–Partner Interdependence Model Approach
Authors: Ha Ju-Young , Ban Seonhwa 
Published: January 2020

Abstract
Background This study aims to analyze the influence of resilience, a positive factor that infertile couples may have, on their quality of life (QoL). Methods Using the method of couples’ data analysis, we analyzed the effect of resilience on the QoL of infertile couples as actors and partners. The subjects of this descriptive causal study were 150 infertile couples. Fertility Quality of Life and Resilience Scale were used to measure couples’ QoL and resilience. The Actor–Partner Interdependence Model was applied to analyze QoL. Results In terms of actor effects, the resilience of both wives (β = .201, p < .001) and husbands (β = .713, p < .001) had a significant effect on individual QoL. With regard to partner effects, husbands’ resilience (β = .351, p < .001) had a significant impact on wives’ QoL, and the wives’ resilience (β = .219, p = .009) had a significant impact on husbands’ QoL. Conclusions The resilience of an infertile actor was found to affect both his or her own QoL as well as that of his or her partner. In the future, if a program is to be developed to improve couples’ QoL, both spouses should work together to improve their resilience, thereby improving their QoL.
Comparative metagenomic analysis of small ruminants' fecal microbiota
Authors: Shabana Iman , Bouqellah N A , Albakri N N 
Published: January 2020

Abstract
Background Ruminant's gastrointestinal tract inhabits complex microbial communities that influence several aspects of their development and health. Due to the limited knowledge of the fecal microbial population of sheep and goats, the current study aimed to determine the core fecal microbiota of sheep and goats at different ages. Metagenomic analysis was performed by Illumina MiSeq targeting the V3-V4 region of the 16S rRNA genes. Fecal samples were collected from sheep and goats aged 6 months and 12 months, obtained from a single farm. The fecal bacterial composition of both species was investigated at the phylum, class, order, family, and genus levels. Observed Species, Chao1, and Shannon indices were calculated to measure the microbial diversity.Results The core phyla of sheep and goats were Firmicutes (>93.01% in sheep, >95.37% in goat), followed by Proteobacteria (>26.83%in sheep, >62.03% in goat). At the genus level, a total of 36 genera were identified. Of these, 10 genera were identified in both sheep and goats including Escherichia (>40.12%), Clostridium (19.38%), Enterococcus (>5.03%), Lysinibacillus (>76.95%) Streptococcus (>2.83%), Anaerocolumna (>1.63%), Anaerotignum (>35.95%), Muricomes (>0.99%), Tissierella (>0.91%) and Bifidobacterium (>0.51%). Alpha diversity indices indicated that the highest level for the complexity of species diversity was detected in sheep fecal samples at 12 months of age.Conclusion Fecal bacterial metagenomic analysis of sheep and goats showed no significant differences in the microbiota composition on the phyla level. There was an increase in microbiota diversity with age at the genus level. Although analyzing the bacterial composition and diversity is important, further studies on their poten­tial functionality are required.
A novel long non-coding RNA LSAMP-1 is down-regulated in non-small cell lung cancer and predicts a poor prognosis
Authors: gong wei , Qiu Fuman , Li Yinyan , Yang Lei , Wang Yuanyuan , Xian Jianfeng , Zhang Xin , Zhou Yifeng , Wang Xinhua , Qiao Guibin , Chen Cuiyi , Gao Xincheng , Lu Jiachun 
Published: January 2020

Abstract
Background There is very little known about how long non-coding RNAs (lncRNAs) are associated with membrane proteins in lung cancer. The limbic system-associated membrane protein ( LSAMP ) has been reported to play a tumor suppressor role in a variety of cancers.Methods We aimed to explore the lncRNA associated with LSAMP and explore its effects on lung cancer.Results We found that Lnc-LSAMP-1 was significantly down-regulated in 170 cases of lung tumor tissues when compared to the adjacent non-cancerous tissues (p<0.001). Our results indicated that low expression of Lnc-LSAMP-1 was significantly correlated with stage (TNM)(p=0.006), N status (p=0.009) and poor prognosis (p=0.004). Further investigation showed that overexpression of Lnc-LSAMP-1 significantly inhibited lung cancer cell proliferation, viability, invasion and migration ability, arrested cell cycle and facilitated apoptosis. Meanwhile, the expression of Lnc-LSAMP-1 is highly correlated with the expression of nearby tumor suppressor gene LSAMP in our samples (r=0.7074, p<0.001) and TCGA database (r=0.78, p<0.001). It was found that overexpression of Lnc-LSAMP-1 can slow down the degradation rate of LSAMP gene by mRNA protection experiments. By knocking down of LSAMP gene, it was found that overexpressed Lnc-LSAMP-1 cells showed a high proliferation rate. Chemotherapy sensitization experiments showed that overexpression of Lnc-LSAMP-1 enhanced TKI inhibition of lung cancer cell proliferation, which is probably related to affecting the prognosis of patients.Conclusions Consequently, the above data suggested that Lnc-LSAMP-1 functions as a tumor suppressor and provides a new potentially therapeutic and prognostic target for non-small cell lung cancer.
Alteration of circulating natural antibodies against VEGFR1-derived peptide antigens in atherosclerosis
Authors: Wang Peng , Liu Siqi , Wang Zhenqi , Zhao Huan , Zhang Xuan 
Published: January 2020

Abstract
Background Several lines of evidence suggest the protective role of natural antibody in common chronic disease like atherosclerosis and cancer. Vascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2) are important regulators of angiogenesis and their involvement in developing atherosclerosis cannot be ruled out. Purpose The present study was designed to develop an in-house enzyme-linked immunosorbent assay to test if natural IgG for VEGFR1 and regulatory T cell markers CD25 and FOXP3 could be associated with atherosclerosis. Methods A total of 218 patients with atherosclerosis and 200 healthy controls were recruited; all patients had atherosclerotic carotid plaque and carotid intima–media thickness was analyzed using a diagnostic ultrasound system. Results Mann-Whitney U test demonstrated that plasma anti-VEGFR1 IgG levels were significantly lower in atherosclerosis patients than control subjects (Z=-2.46, P =0.014) although neither anti-CD25 IgG levels nor anti-FOXP3 IgG levels showed significant changes. Male patients mainly contributed to the decreased antiVEGFR1 IgG levels (Z=-2.45, P =0.014). Spearman correlation analysis failed to show any significant correlation between natural IgG levels and carotid intima–media thickness. Conclusion Decreased levels of anti-VEGFR1 IgG may be involved in developing atherosclerosis-related conditions.
Application of ox muzzle drainage in knee arthroscopy
Authors: Lu daifeng , Li Jingbo , Zhang Zhitao , Xiao Mochao 
Published: January 2020

Abstract
Background: Ox muzzle drainage is a type of drainage system surrounding the anterior internal and lateral incision of knee arthroscopy. This study investigated the role of ox muzzle drainage in keeping the surgical field clear and decreasing the operative time in knee arthroscopy.Methods: A total of 63 patients with meniscal associated injury who underwent knee arthroscopic meniscus partial resection between May 2011 and June 2014 were retrospectively analyzed. Ox muzzle drainage was applied in 31 patients, while the other 32 patients were served as conventional drainage group. The volume of irrigation fluid drained from the knee articular cavity, duration of operation, operative view clarity and complications were compared. Visual clarity was rated by a Numeric Rating Scale.Results: The irrigation fluid volume was significantly greater, while duration of operation was markedly shorter in the ox muzzle drainage group than the control (P<0.05). The operative view clarity in the ox muzzle drainage group was obviously better than the control (P<0.05). One patient in the ox muzzle drainage group developed articular effusion of the knee joint after the operation, which improved markedly after paracentesis and betamethasone articular injection at 3 months after operation. Two patients in the control group experienced reddening at the incision, leading to delayed wound healing. No statistical difference was observed in the number of complications after operation between the two groups (P>0.05). Conclusions: Ox muzzle drainage is feasible for intra-operative irrigation and stretching of the fat pad in knee arthroscopy, offering the advantage of a shorter operation time and, thus, potentially improved safety.
Recurrent Retinal Detachment after Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment
Authors: Fu Yan , Zhang Yue-ling , Gu Zhaohui , Geng Ren-Fei , Yuan Xin-Yu 
Published: January 2020

Abstract
Background The recurrence of retinal detachment (RD) following rhegmatogenous retinal detachment (RRD) is a relatively common complication that threatens vision and needs further surgery. The purpose of this study is to investigate the risk factors and visual outcomes of recurrent RD following pars plana vitrectomy (PPV) for primary RRD.Methods This was a retrospective follow-up of 343 eyes that underwent initial PPV surgery for primary RRD. Patients were divided into a recurrence group and a reattachment group. The main outcome measures included the causative factors, visual outcomes of RD recurrence, and the perioperative factors most affecting the recurrence of RD.Results After retinal reattachment, we observed recurrence of RD after PPV for primary RRD in 42 out of 343 eyes (12.2%) during the follow-up period. Most recurrence (69%) occurred within 6 months after surgery. Univariate analysis showed that the primary risk factor significantly associated with recurrent RD was the presence of proliferative vitreoretinopathy (PVR) ≥ Grade C ( P = 0.003). Logistic regression analysis showed that a PVR ≥ Grade C (odds ration [OR]: 9.421, 95% confidence interval [CI]: 2.432 - 56.39; P =0.020) was a significant predictor for the development of recurrent RD. The recurrence of RD resulted in a significant decline in best-corrected visual acuity (BCVA) at the last follow-up visit compared with the reattachment group ( P =0.000). Eyes with PVR prior to primary surgery or at the diagnosis of re-detachment showed a worse final BCVA.Conclusions The presence of PVR ≥ Grade C was the predominant risk factor for the recurrence of RD. PVR prior to primary surgery, or at the diagnosis of re-detachment, limited the recovery of final visual acuity.
Tuberculosis cases in cross-regional floating population from 2009 to 2017 in Shaanxi Province, China
Authors: Men Ke , Zhang Hairui , Liu Weiping , Han Henry 
Published: January 2020

Abstract
Background : The cross-regional population of tuberculosis (TB) has become an important part of the prevention and control of TB cases in China with the gradually increasing of floating population. The aim of our study was to explore the main epidemiological characteristics and provide reference for the treatment and management of TB cases in cross-regional floating population in Shaanxi Province. Methods: The data of TB cases in cross-regional floating population from 2009 to 2017 were derived from the National Tuberculosis Management Information Registration System. Descriptive analysis was applied for the baseline demographical, continuous data are expressed as means ± standard deviation and categorical in percentage. The χ2 test, which was implemented as Fisher’s exact test in this study, was applied to categorical variable comparisons. Results: A total of 613 floating TB cases consisting of 413 males (67.4%) and 200 females (32.6%) were registered in Shaanxi province from 2009 to 2017. The difference of gender distribution was statistically significant ( P =0.039). Of the total, 190 cases (31.0%) were smear-positive and 175 cases (28.5%) were negative. From 2009 to 2017, the difference of the gender distribution was not statistically significant ( P =0.732), but the difference in the rate of transferred into original was found statistically significant ( P =0.000). Conclusion: The number of TB cases in cross-regional floating population in Shaanxi Province showed a relatively stable trend from 2009 to 2017. Young males should be given more attentions in TB control because they counted most of the TB cases.
The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population
Authors: Zhang Jin-Yu , Zhao Qian , Li Xiao-Mei , Liu Fen , Zhao Qiang , Men Li , Chen Qing-Jie , Zhai Hui , Luo Jun-Yi , Yang Yining 
Published: January 2020

Abstract
Background: Coronary artery disease (CAD) is the most common type of heart disease and causes high morbidity worldwide. The β3-adrenergic receptor gene (ADRB3) is potentially linked to obesity, insulin resistance, diabetes, and hypertension based on its role in energy homeostasis and lipolysis in human adipose tissue. However, the relationship between ADRB3 gene polymorphisms and CAD remains unclear. we sought to assess this association in the Han and Uygur populations of China. Methods: We used the following two case-control studies: a Han population (308 CAD patients and 294 control subjects) and an Uygur population (259 CAD patients and 161 control subjects). All 1022 participants were genotyped for the two single nucleotide polymorphisms (SNPs) (rs1892818, rs9693898) of ADRB3 using real-time polymerase chain reaction (TaqMan). Results: We found that the rs1892818 CT genotype (8.5% compared with 3.9%, P = 0.019) and T allele (4.3% compared with 1.9%, P = 0.021) were more frequent in control subjects than in CAD patients of the Han, but not Uygur population. No significant differences in rs9693898 of ADRB3 were found between CAD patients and control subjects for both populations. After adjusting for other confounders, logistic regression analysis suggested that the difference remained significant between the two groups in the Han population (CT compared with CC, P = 0.036, OR = 0.410, 95% CI: 0.178–0.944). Conclusion: Our results suggest that ADRB3 rs1892818 is associated with CAD in a Han population and that the CT genotype of ADRB3 rs1892818 might be a protective factor for CAD in Han individuals.