bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging
Authors: Cho Hye Rim , Kumari Nisha , Thakur Nishant , Vu Hien Thi , Kim Hyeonjin , Choi Seung Hong 
Published: November 2019

AbstractGlioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor survival rates. The current standard treatment includes chemotherapy with temozolomide (TMZ), but acquisition of resistance is a persistent clinical problem limiting the successful treatment of GBM. The purpose of our study was to investigate therapeutic effects of nitroxoline (NTX) against TMZ-resistant GBM in vitro and in vivo in TMZ-resistant GBM-bearing mouse model, which was correlated with diffusion-weighted imaging (DWI). For in vitro study, we used TMZ-resistant GBM cell lines and evaluated therapeutic effects of NTX by clonogenic and migration assays. Quantitative RT-PCR was used to investigate the expression level of TMZ-resistant genes after NTX treatment. For in vivo study, we performed 9.4 T MR imaging to obtain T2WI for tumor volume measurement and DWI for assessment of apparent diffusion coefficient (ADC) changes by NTX in TMZ-resistant GBM mice (n = 8). Moreover, we performed regression analysis for the relationship between ADC and histological findings, which reflects the changes in cellularity and apurinic/apyrimidinic endonuclease-1 (APE-1) expression. We observed the recovery of TMZ-induced morphological changes, a reduced number of colonies and a decreased rate of migration capacity in TMZ-resistant cells after NTX treatment. The expression of APE-1 was significantly decreased in TMZ-resistant cells after NTX treatment compared with those without treatment. In an in vivo study, NTX reduced tumor growth in TMZ-resistant GBM mice (P = 0.0122). Moreover, ADC was increased in the NTX-treated TMZ-resistant GBM mice compared to the control group (P = 0.0079), which was prior to a tumor volume decrease. The cellularity and APE-1 expression by histology were negatively correlated with the ADC value, which in turn resulted in longer survival in NTX group. The decreased expression of APE-1 by NTX leads to therapeutic effects and is inversely correlated with ADC in TMZ-resistant GBM. Therefore, NTX is suggested as potential therapeutic candidate against TMZ-resistant GBM.
Mitochondrial somatic mutations and the lack of viral genomic variation in recurrent respiratory papillomatosis
Authors: Hao Yuhan , Ruiz Ryan , Yang Liying , Neto Antonio Galvao , Amin Milan R. , Kelly Dervla , Achlatis Stratos , Roof Scott , Bing Renjie , Kannan Kasthuri , Brown Stuart M. , Pei Zhiheng , Branski Ryan C. 
Published: November 2019

AbstractRecurrent Respiratory Papillomatosis (RRP) is a rare disease of the aerodigestive tract caused by the Human Papilloma Virus (HPV) that manifests as profoundly altered phonatory and upper respiratory anatomy. Current therapies are primarily symptomatic; enhanced insight regarding disease-specific biology of RRP is critical to improved therapeutics for this challenging population. Multiplex PCR was performed on oral rinses collected from twenty-three patients with adult-onset RRP every three months for one year. Twenty-two (95.6%) subjects had an initial HPV positive oral rinse. Of those subjects, 77.2% had an additional positive oral rinse over 12 months. A subset of rinses were then compared to tissue samples in the same patient employing HPViewer to determine HPV subtype concordance. Multiple HPV copies (60–787 per human cell) were detected in RRP tissue in each patient, but a single dominant HPV was found in individual samples. These data confirm persistent oral HPV infection in the majority of patients with RRP. In addition, three novel HPV6 isolates were found and identical HPV strains, at very low levels, were identified in oral rinses in two patients suggesting potential HPV subtype concordance. Finally, somatic heteroplasmic mtDNA mutations were observed in RRP tissue with 1.8 mutations per sample and two nonsynonymous variants. These data provide foundational insight into both the underlying pathophysiology of RRP, but also potential targets for intervention in this challenging patient cohort.
Synthesis of pure and C/S/N co-doped Titania on Al mesh and their photocatalytic usage in Benzene degradation
Authors: Modanlu S. , Shafiekhani A. 
Published: November 2019

AbstractPure and co-doped Titania thin films were prepared on aluminum substrates through the sol-gel method. The co-doped sample showed higher photocatalytic activity on benzene degradation compared to pure TiO2 under visible light illumination. XRD results showed the anatase phase for both TiO2 and co-doped TiO2 lattices with an average crystalline size of 12.9 and 10.4 nm, respectively. According to the UV-visible absorption spectra results, co-doped Titania showed higher visible light absorption compared to pure Titania. The synergistic effect of dopants caused a redshift to visible light absorption and also the lifetime of the photogenerated electron-hole were increased by induced electron levels in Titania lattice. The novelty of this study is the reactor’s specific design. We employed Al mesh as thin film substrate for 3 main reasons, first, the large surface area of the Al mesh causes to increase specific surface area of the photocatalysts, also it is a formable substrate which can be engineered geometrically to decrease the shadow spots so the thin films will receive the highest light irradiation. Also, the Al mesh flexibility facilitates the procedure of reactor design to reach a minimum pressure drop of airflow while it is installed in the air conditioners or HVAC systems.
Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin
Authors: Madrigal-Bujaidar Eduardo , Pérez-Montoya Edilberto , García-Medina Sandra , Cristóbal-Luna José Melesio , Morales-González José A. , Madrigal-Santillán Eduardo Osiris , Paniagua-Pérez Rogelio , Álvarez-González Isela 
Published: November 2019

AbstractGrapefruit juice (GFJ) and naringin when consumed previously or together with medications may alter their bioavailavility and consequently the clinical effect. Ifosfamide (IF) is an antitumoral agent prescribed against various types of cancer. Nevertheless, there is no information regarding its interaction with the ingestion of GFJ or naringin. The aims of the present report were validating a method for the quantitation of IF in the plasma of mouse, and determine if mice pretreated with GFJ or naringin may modify the IF pharmacokinetics. Our HPLC results to quantify IF showed adequate intra and inter-day precision (RSD < 15%) and accuracy (RE < 15%) indicating reliability. Also, the administration of GFJ or naringin increasedCmaxof IF 22.9% and 17.8%, respectively, and decreasedTmaxof IF 19.2 and 53.8%, respectively. The concentration of IF was higher when GFJ (71.35 ± 3.5 µg/mL) was administered with respect to that obtained in the combination naringin with IF (64.12 ± µg/mL); however, the time required to reach such concentration was significantly lower when naringin was administered (p < 0.5). We concluded that pre-administering GFJ and naringin to mice increased theTmaxand decreased theCmaxof IF.
Dietary energy and protein levels influenced the growth performance, ruminal morphology and fermentation and microbial diversity of lambs
Authors: Cui Kai , Qi Minli , Wang Shiqin , Diao Qiyu , Zhang Naifeng 
Published: November 2019

AbstractThe aim of the study was to evaluate the ruminal function and microbial community of lamb under different nutrient levels. Sixty-four lambs with similarity body weight were randomly assigned to four groups after weaning off ewe’s milk on the 17th day (6.2 ± 0.2 kg). The lambs of the control group (CON) were fed a basal diet, and the other three groups were subjected to a diet of decreased protein (PR), digestible energy (ER) or both of them at 20% (BR) of basal diet. The decrease of dietary protein or energy level decreased the average daily gain, ruminal weight and mucosal thickness of lambs (P < 0.05). The total volatile fatty acid (TVFA), acetate and propionate concentration of the CON group were significantly higher than that of the other three groups. The dietary protein and energy level affected the microbial diversity, and low energy level increased the relative abundance of phyla of Fibrobacteres, whereas at the genus level, increased the relative abundance of Butyrivibrio and Prevotellaceae. Under different dietary energy and protein levels, 14 genera exhibited significant correlation with ruminal fermentation. These findings supplied new perspective for the understanding of the dietary effect on ruminal microbial community interactions and are of great significance for establishing the optimal nutrient supply strategy for lambs.
Morphology and physiology of olfactory neurons in the lateral protocerebrum of the silkmoth Bombyx mori
Authors: Namiki Shigehiro , Kanzaki Ryohei 
Published: November 2019

AbstractInsect olfaction is a suitable model to investigate sensory processing in the brain. Olfactory information is first processed in the antennal lobe and is then conveyed to two second-order centres—the mushroom body calyx and the lateral protocerebrum. Projection neurons processing sex pheromones and plant odours supply the delta area of the inferior lateral protocerebrum (∆ILPC) and lateral horn (LH), respectively. Here, we investigated the neurons arising from these regions in the brain of the silkmoth, Bombyx mori, using mass staining and intracellular recording with a sharp glass microelectrode. The output neurons from the ∆ILPC projected to the superior medial protocerebrum, whereas those from the LH projected to the superior lateral protocerebrum. The dendritic innervations of output neurons from the ∆ILPC formed a subdivision in the ∆ILPC. We discuss pathways for odour processing in higher order centres.
Unveiling the vortex glass phase in the surface and volume of a type-II superconductor
Authors: Aragón Sánchez Jazmín , Cortés Maldonado Raúl , Cejas Bolecek Néstor R. , Rumi Gonzalo , Pedrazzini Pablo , Dolz Moira I. , Nieva Gladys , Beek Cornelis J. van der , Konczykowski Marcin , Dewhurst Charles D. , Cubitt Robert , Kolton Alejandro B. , Pautrat Alain , Fasano Yanina 
Published: November 2019

AbstractOrder-disorder transitions between glassy phases are common in nature and yet a comprehensive survey on the entailed structural changes is challenging since the constituents are in the micro-scale. Vortex matter in type-II superconductors is a model system where some of these experimental challenges can be tackled. Samples with point disorder present a glassy transition on increasing the density of vortices. A glassy yet quasi-crystalline phase, the Bragg glass, nucleates at low densities. The vortex glass stable at high densities is expected to be disordered, however its detailed structural properties remained experimentally elusive. Here we show that the vortex glass has large crystallites with in-plane positional displacements growing algebraically and short-range orientational order. Furthermore, the vortex glass has a finite and almost constant correlation length along the direction of vortices, in sharp contrast with strong entanglement. These results are important for the understanding of disorder-driven phase transitions in glassy condensed matter.
Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials
Authors: Naame Saavia Alice , Li Decheng , Huang Ruixue 
Published: November 2019

Abstract
Background: Diabetes mellitus is of major public health concerns; its incidence is continuously increasing. Diabetes mellitus is associated with a high risk of cardiovascular complications such as hypertension. Red wine has been reported to reduce cardiovascular risk factors. We quantified the effects of red wine on cardiovascular factors. Methods: We retrieved English-language articles published from January 1990 to April 2019. Cardiovascular risk factors were compared using means with 95% confidence intervals (95% CIs). Results: We identified five eligible randomized controlled trials. Diabetic patients who drank red wine exhibited significantly reduced systolic blood pressure (BP) (mean difference [MD] −1.33, 95% CI −1.81, −0.85) and diastolic BP (MD −1.31, 95% CI −1.80, −0.83) than those who did not. Compared to the observations for diabetics who did not drink red wine, the high-density lipoprotein (HDL) level was significantly higher in red wine drinkers (MD −0.24, 95% CI −0.39, −0.09). However, red wine had no effect on the body mass index (BMI) (MD −0.27, 95% CI −1.80, 1.25), the total cholesterol level (MD 0.13, 95% CI −0.17, 0.44), or the low-density lipoprotein (LDL) level (MD 0.08, 95% CI −0.21, 0.37). Conclusions: Red wine consumption significantly lowered BP and increased the HDL level in diabetics. Red wine had no significant effect on BMI or cholesterol and LDL levels. Given the heterogeneity of the studied populations and the lack of standardization and completeness across the published studies, caution is required while interpreting these findings.
Erkannt und konsequent erfolgreich behandelt: Reanimation bei Lungenarterienembolie
Authors: Grohé Maximilian , Asmus Jens , Bohn Andreas , Sackarnd Jan 
Published: November 2019

ZusammenfassungEs wird von einem 63-jährigen Patienten mit Luftnot berichtet. Während der Versorgung durch den Notarzt wurde der Patient reanimationspflichtig. Die Diagnose einer fulminanten Lungenembolie wurde auf klinischer Basis gestellt. Aufgrund der sofort eingeleiteten Reanimation, der potenziell reversiblen Ursache und dem Potenzial des Patienten wurde der Patient unter mechanischer Reanimation in ein Cardiac-Arrest-Center transportiert, da vor Ort kein Spontankreislauf etabliert werden konnte. Dort erfolgte die weitere Versorgung unter extrakorporaler Reanimation (eCPR). Zur Versorgung hat der Rettungsdienst mit dem Cardiac-Arrest-Center des Universitätsklinikums ein Konzept etabliert. Dieses wird im Rahmen der Fallvorstellung dargestellt. Es wird auf Chancen und Grenzen eines Konzeptes zur eCPR eingegangen.
É importante saber onde posicionar o marcador esférico para o planejamento digital de artroplastia de quadril?
Authors: Polesello Giancarlo Cavalli , Salerno Thiago Tronco , Rezende João Hélio Zucarelli , Ricioli Junior Walter , Rabelo Nayra Deise , de Queiroz Marcelo Cavalheiro 
Published: November 2019

Resumo
Objetivo Os objetivos desse artigo são avaliar as influências das características pessoais na magnificação radiográfica e identificar o método de maior acurácia e o mais adequado.
Métodos Durante o exame radiográfico em 50 pacientes com prótese de quadril, foram coletados dados antropométricos e posicionados quatro marcadores metálicos esféricos: ao nível e lateral ao trocânter maior, na sínfise púbica, ao nível do trocânter maior entre as coxas, sobre a mesa do exame. A cabeça da prótese é o melhor marcador radiográfico interno e foi o nosso parâmetro de calibragem. Dois avaliadores mediram as imagens desses marcadores para análise de resultados.
Resultados Foram selecionados 50 participantes, sendo 19 do sexo masculino. Houve diferença de magnificação entre os sexos na posição sínfise púbica. As outras características pessoais avaliadas (peso, altura e índice de massa corpórea) tiveram correlação fraca. A maior acurácia do marcador foi no trocânter maior, entre 68,4 e 78,9%, visualizado em apenas 19 radiografias. O marcador entre as coxas obteve acurácia entre 30 e 46% e foi visualizado em todas as radiografias.
Conclusão Das características pessoais, apenas o sexo influencia a magnificação e somente na posição da sínfise púbica. Sugerimos padronizar o uso de duas esferas: no trocanter maior, pela maior acurácia, e entre as coxas, por ser o mais adequado e com melhor visibilidade em todas radiografias.
Differences in color categorization manifested by males and females: a quantitative World Color Survey study
Authors: Fider Nicole A. , Komarova Natalia L. 
Published: November 2019

AbstractGender-related differences in human color preferences, color perception, and color lexicon have been reported in the literature over several decades. This work focuses on the way the two genders categorize color stimuli. Using the cross-cultural data from the World Color Survey (WCS) and rigorous mathematical methodology, a function is constructed, which measures the differences in color categorization systems manifested by men and women. A significant number of cases are identified, where men and women exhibit markedly disparate behavior. Interestingly, of the regions in the Munsell color array, the green-blue (“grue”) region appears to be associated with the largest group of categorization differences, with females revealing a more differentiated color categorization pattern compared to males. More precisely, in those cases, females tend to use separate green and/or blue categories, while males predominantly use the grue category. In general, the cases singled out by our method warrant a closer study, as they may indicate a transitional categorization scheme.
Structure of life satisfaction from the perspective of arts experiences in Japan
Authors: Iida Seira 
Published: November 2019

AbstractApproximately 40% of elementary school girls have some type of arts experience, such as dancing and playing instruments, as out-of-school activities. However, its effect has not been clearly revealed. This is mainly because the effects of the arts were not a major topic of discussion in Japan so there has been little data about the arts. With the precise knowledge, we could start considering how to take the benefits of the arts. Thus, this paper empirically analyzed the effects of the arts on quality of life in the case of Japan. The aim was to reveal the impacts of arts experiences in order to consider how to support or make use of the arts. It utilized structural equation modeling to reveal the relationships between the number of the arts experience types in elementary school and life satisfaction. The nationwide data from the Preference Parameters Study in 2013 was primarily utilized. The sample size was 1532, including 823 females and 709 males. The results showed significant positive relationships between the number of the arts experience types and life satisfaction through attitudes, present behaviors related to the arts, and leisure satisfaction. The results suggested two issues; arts experience in elementary school years helped to cultivate the mind to enjoy the arts and also the arts played the role to increase one’s quality of life.
“Put a little bit of humor into it”
Authors: Shively Rachel L. , Mir Montserrat 
Published: November 2019

Abstract
This study examines the use of teacher humor in whole-group interactions in beginning-level Spanish foreign
language (FL) classes. Previous research has focused primarily on student humor and on humor in intermediate- and advanced-level
FL courses. Hence, the goals of the research were, first, to determine whether teachers use spontaneous verbal humor in
beginning-level courses and, if so, in what ways. Second, we considered whether the amount of teacher humor was related to the
amount of student humor. The findings indicate that many of the instructors in the study did, indeed, joke around with their
students. Most teacher humor was affiliative or rapport-enhancing, delivered in the target language, and designed with students’
L2 abilities in mind. Finally, in classes in which teachers joked more often, there was a tendency for students to joke more often
as well, suggesting that teacher humor may encourage student humor.
Vilnius memoryscape
Authors: Moore Irina 
Published: November 2019

AbstractThrough the lens of semiotic landscapes, I analyse here collective memory formation in the Baltic republic of Lithuania. A theoretical focus on power relation in “monumental politics”, the concept of memoryscape (Clack, 2011),Van Gennep’s 2004sociological application of liminality, and a methodological approach that “treats space as a discursive as well as physical formation” (Jaworski & Thurlow, 2010) are combined to examine the process of monument destruction, creation, and alteration in post-Soviet Vilnius. I argue that cultural landscapes represent not only relationships of power within societies but are also used as a tool of nation-building and power legitimation. I highlight a fourfold process: (1) razing – monumental landscape cleansing; (2) raising – the return of memory via the creation of national historical continuity symbols and of newlieux de mémoire(Nora, 1996) and the memorization complex (Train, 2016); (3) polyphonic memorial narratives of empty spaces; and (4) the memory limbo helix or recursive memories.
The landscape returns the gaze
Authors: Pennycook Alastair 
Published: November 2019

AbstractThis paper looks at bikescapes – and particularly dockless share bikes – with a focus on their rapid proliferation and subsequent partial demise in Sydney. Four principal themes emerged from this study: first, bikes are an important part of the cityscape, and studies of urban semiotics need to take greater account of modes of transport. Second, the rise of docked and dockless share bikes has changed the ways the city is felt and perceived: as bikes circulate within the city, these shifting bikescapes make visible changes to the physical city environment. The ebb and flow of dockless bikes – from neat alignments to dispersed arrangements – provide an insight into changing patterns of work, leisure, and mobility, and present entropic rather than ordered city processes. Third, these bikes became significant discourse markers, material artefacts where discourses of consumption, convenience, contamination, and co-operation intersect. Dockless share bikes sit at the hub of a tussle over public and private ownership of space and information, in terms both of their physical incursion into public space and as syphons of personal information. Finally, they suggest not only that aspects of the cityscape may play an active role in semiotic networks, but that the semiotic landscape may be returning our gaze.
The Influence of Palm Shell as Aggregate Substitution to The Compressive Normal Concrete Strength
Authors: Yusra A , Opirina L 
Published: November 2019

Abstract
The main objective of this paper was to study the influence of palm shell used as aggregate substitution to achieve structural concrete with lighter weight than normal concrete. Instead of normal aggregate, the alternative aggregate palm shell was used with variation of substitution consisting of 0%, 15%, 30%, 35% and 65% of palm shell by weight of aggregates. Water-cement ratio was 0.40 of and f’c 30 MPa. The test result conducted on the 28th day showed that the strength was increased. However, as the Palm Shell percentages increased, the compressive strength decreased. The normal concrete (0%) of palm shell was resulted 46.188 MPa of strength and the substitution of 15%, 30%, 45% and 60% was 42.917 MPa, 23.287 MPa, 18.860 MPa and 8.468 MPa. There was a reduction in the strength at 0% substitution compared to 60% substitution, and it occurred reduction weight of concrete with 0%, 15%, 30%, 45% and 60% substitution of palm shell that gave result 2528 kg/m3, 2359 kg/m3, 2053 kg/m3, 1990 kg/m3 and 1809 kg/m3 concrete weight. As a result, it shows that the concrete using 0% of palm shell substitution can be categorized as a high strength concrete for 60% substitution palm gave non-structural concrete with lightweight concrete.