bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Mutations in NSP1 and PLPro of SARS-CoV-2 NIB-1 Genome Mount for Effective Therapeutics
Authors: Hossain Mohammad Uzzal , Bhattacharjee Arittra , Emon Md. Tabassum Hossain , Chowdhury Zeshan Mahmud , Mosaib Md. Golam , Moniruzzaman Md. , Rahman Md. Hadisur , Islam Md. Nazrul , Ahmed Irfan , Amin Md. Ruhul , Rashed Asif , Das Keshob Chandra , Keya Chaman Ara , Salimullah Md. 
Published: December 2020

AbstractSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the etiologic agent of Coronavirus Disease-2019 (COVID-19), is rapidly accumulating new mutations. Analysis of these mutations is necessary for gaining knowledge regarding different aspects of therapeutic development. Recently, we have reported a Sanger method based genome sequence of a viral isolate named SARS-CoV-2 NIB-1, circulating in Bangladesh. The genome has four novel mutations in V121D, V843F, A889V and G1691C positions. V121D substitution has the potential to destabilize the Non-Structural Protein (NSP-1) which inactivates the type-1 Interferon-induced antiviral system hence this mutant could be the basis of attenuated vaccines against SARS-CoV-V843F, A889V and G1691C are all located in NSP3. G1691C can decrease the flexibility of the protein while V843F and A889V changed the binding pattern of SARS-CoV-2 Papain-Like protease (PLPro) inhibitor GRL0617. V843F PLPro showed reduced affinity for Interferon Stimulating Gene-15 (ISG-15) protein whereas V843F+A889V double mutants exhibited the same binding affinity as wild type PLPro. Here, V843F is a conserved position of PLPro that damaged the structure but A889V, a less conserved residue, most probably neutralized that damage. Mutants of NSP1 could provide attenuated vaccines against coronavirus. Also, these mutations of PLPro could be targeted to develop anti-SARS therapeutics.
The role of replication clamp-loader protein HolC ofEscherichia coli in overcoming replication / transcription conflicts
Authors: Cooper Deani L. , Harada Taku , Tamazi Samia , Ferrazzoli Alexander E. , Lovett Susan T. 
Published: December 2020

ABSTRACTInEscherichia coli,DNA replication is catalyzed by an assembly of proteins, the DNA polymerase III holoenzyme. This complex includes the polymerase and proofreading subunits as well as the processivity clamp and clamp loader complex. TheholCgene encodes an accessory protein (known as x) to the core clamp loader complex and is the only protein of the holoenzyme that binds to single-strand DNA binding protein, SSB. HolC is not essential for viability although mutants show growth impairment, genetic instability and sensitivity to DNA damaging agents. In this study, to elucidate the role of HolC in replication, we isolate spontaneous suppressor mutants in aholCΔstrain and identify these by whole genome sequencing. Some suppressors are alleles of RNA polymerase, suggesting that transcription is problematic forholCmutant strains orsspA,stringent starvation protein. Using a conditionalholCplasmid, we examine factors affecting transcription elongation and termination for synergistic or suppressive effects onholCmutant phenotypes. Alleles of RpoA (α), RpoB (β) and RpoC (β’) RNA polymerase holoenzyme can partially suppress loss of HolC. In contrast, mutations in transcription factors DksA and NusA enhanced the inviability ofholCmutants. Mfd had no effect nor did elongation factors GreA and GreB. HolC mutants showed enhanced sensitivity to bicyclomycin, a specific inhibitor of Rho-dependent termination. Bicyclomycin also reverses suppression ofholCbyrpoA rpoCandsspA.These results are consistent with the hypothesis that transcription complexes block replication inholCmutants and Rho-dependent transcriptional termination and DksA function are particularly important to sustain viability and chromosome integrity.IMPORTANCETranscription elongation complexes present an impediment to DNA replication. We provide evidence that one component of the replication clamp loader complex, HolC, ofE. coliis required to overcome these blocks. This genetic study of transcription factor effects onholCgrowth defects implicates Rho-dependent transcriptional termination and DksA function as critical. It also implicates, for the first time, a role of SspA, stringent starvation protein, in avoidance or tolerance of replication/replication conflicts. We speculate that HolC helps resolve codirectional collisions between replication and transcription complexes, which become toxic in HolC’s absence.
pyActigraphy: open-source python package for actigraphy data visualisation and analysis
Authors: Hammad Grégory , Reyt Mathilde , Beliy Nikita , Baillet Marion , Deantoni Michele , Lesoinne Alexia , Muto Vincenzo , Schmidt Christina 
Published: December 2020

AbstractOver the past 40 years, actigraphy has been used to study rest-activity patterns in circadian rhythm and sleep research. Furthermore, considering its simplicity of use, there is a growing interest in the analysis of large population-based samples, using actigraphy. Here, we introducepyActigraphy, a comprehensive toolbox for data visualization and analysis including multiple sleep detection algorithms and rest-activity rhythm variables. This open-source python package implements methods to read multiple data formats, quantify various properties of rest-activity rhythms, visualize sleep agendas, automatically detect rest periods and perform more advanced signal processing analyses. The development of this package aims to pave the way towards the establishment of a comprehensive open-source software suite, supported by a community of both developers and researchers, that would provide all the necessary tools for in-depth and large scale actigraphy data analyses.Required MetadataCurrent code version
The analysis of influencing factors on the going concern audit opinion – a study in manufacturing firms in Indonesia
Authors: Averio Thomas 
Published: December 2020

PurposeIt is argued that the going concern opinion is issued if auditors have a doubt about financial condition of a company. Provision of the going concern audit opinion may worsen the company in terms of gaining public trust and may even indicate bankruptcy. This study aims to determine the factors that affect the auditor's going concern opinion.Design/methodology/approachThis research used secondary data obtained from annual reports and independent audit reports published by the Indonesia Stock Exchange. The population of this research included manufacturing firms registered in the Indonesia Stock Exchange from 2015 to 2019. The sample after the purposive sampling technique being applied consisted of 33 companies. The data were analyzed using logistic regression performed in the statistical analysis software, SPSS 24.0.FindingsThe results indicated that leverage positively affected the going concern audit opinion, then the audit quality, profitability and liquidity negatively affected the going concern audit opinion, whereas firm size and audit lag did not affect the going concern audit opinion.Originality/valueThis study is in contrast to several existing studies on the determinants of the auditor's going concern opinion and provides knowledge on developing more factors affecting the auditor's going concern opinion.
The thematic landscape of literature on supply chain management in India: a systematic literature review
Authors: Sahu Srichandan , Rao K.V.S.S. Narayana 
Published: December 2020

PurposeTo assess the state of supply chain management (SCM) research in India and to understand the research trends and methodologies used. The present study also aims to create a taxonomy of the subject areas researched in India.Design/methodology/approachThe present study employed the systematic literature review methodology. Literature from 395 peer journal papers in 67 leading journals over a 20-year period (2000–2020 Quarter-1) was comprehensively reviewed and assessed.FindingsSCM research in India started around the year 2000. The quantum of research was low (single digit) until 2010. There has been steady growth over the last decade, and over 50% of the total papers up until now has been published in the last four years. The present study created a three-tiered taxonomy of the subject areas and classified the papers as per it. The first tier (level-1) has seven categories (SCM strategy, network design, SCM processes and integration, IT systems, skills, performance measurement and others). A perusal of the newly created taxonomy revealed that, except for a few areas under level-1 categories (such as SCM processes and SCM strategy), the other level-1 categories have not seen much research. Similarly, there is little or no research in a large number of level-2 categories (such as outsourcing strategy, channel strategy, demand management, demand fulfillment, customer relationship management, integrated supply chain planning, new product development, returns, supply chain orientation, performance monitoring, performance improvement, SCM adoption process, SCM implementation issues and quantified benefits of SCM). Methodologically, the rigor of SCM research in India needs improvement.Originality/valueA comprehensive taxonomy of SCM subject areas researched in India at three cascading levels was created for the first time in the present study. The taxonomy will help provide researchers with a clear understanding of the structure of the subject areas and help in identifying areas where research has been carried out and the subject areas where gaps exist for future research to proceed. The present study also provides an overview of the methodological rigor of SCM research in India and points out some of the limitations that researchers should avoid in future studies.
Lost (and found?) in translation: key terminology in disaster studies
Authors: Chmutina Ksenia , Sadler Neil , von Meding Jason , Abukhalaf Amer Hamad Issa 
Published: December 2020

PurposeDisaster studies has emerged as an international interdisciplinary body of knowledge; however, similar to other academic disciplines, its terminology is predominantly anglophone. This paper explores the implications of translating disaster studies terminology, most often theorised in English, into other languages and back.Design/methodology/approachThe authors chose six of the most commonly used (as well as debated and contested) terms that are prominent in academic, policy and public discourses: resilience, vulnerability, capacity, disaster, hazard and risk. These words were translated into 54 languages and the meanings were articulated descriptively in cases where the translation did not have exactly the same meaning as the word in English. The authors then analysed these meanings in order to understand implications of disaster scholars working between dominant and “peripheral” languages.FindingsFindings of the study demonstrate that many of the terms so casually used in disaster studies in English do not translate easily – or at all – opening the concepts that are encoded in these terms for further interpretation. Moreover, the terms used in disaster studies are not only conceptualised in English but are also tied to an anglophone approach to research. It is important to consider the intertwined implications that the use of the terminology carries, including the creation of a “separate” language, power vs communication and linguistic imperialism.Originality/valueUnderstanding of the meaning (and contestation of meaning) of these terms in English provides an insight into the power relationships between English and the other language. Given the need to translate key concepts from English into other languages, it is important to appreciate their cultural and ideological “baggage”.
Achieving data security and privacy across healthcare applications using cyber security mechanisms
Authors: Zhu Shanying , Saravanan Vijayalakshmi , Muthu BalaAnand 
Published: December 2020

Purpose
Currently, in the health-care sector, information security and privacy are increasingly important issues. The improvement in information security is highlighted in adopting digital patient records based on regulation, providers’ consolidation, and the growing need to exchange information among patients, providers, and payers.

Design/methodology/approach
Big data on health care are likely to improve patient outcomes, predict epidemic outbreaks, gain valuable insights, prevent diseases, reduce health-care costs and improve analysis of the quality of life.

Findings
In this paper, the big data analytics-based cybersecurity framework has been proposed for security and privacy across health-care applications. It is vital to identify the limitations of existing solutions for future research to ensure a trustworthy big data environment. Furthermore, electronic health records (EHR) could potentially be shared by various users to increase the quality of health-care services. This leads to significant issues of privacy that need to be addressed to implement the EHR.

Originality/value
This framework combines several technical mechanisms and environmental controls and is shown to be enough to adequately pay attention to common threats to network security.
A three-dimensional computational analysis of ellipsoidal radiator with phase change
Authors: Abu-Hamdeh Nidal H. , Akbal Ömer , Öztop Hakan F. , M. Abusorrah Abdullah , Bayoumi Mohannad M. 
Published: December 2020

Purpose
The purpose of this paper is to solve the problem of a three-dimensional computational analysis for an elliptic-shaped cavity in a pipe under constant temperature.

Design/methodology/approach
The three-dimensional computational solution of governing equations was performed by using finite volume method with different temperature difference.

Findings
The parafin wax was chosen as a phase change material (PCM), and melting fraction, streamlines and isotherms are formed for different time step. It is found that position B give better results than that of position A, and temperature difference effects the duration of melting of PCM.

Originality/value
The three-dimensional analysis of melting in an ellipsoidal pipe with inner pipe with higher temperature is the main originality of this work.
Universal gripper for fabrics – design, validation and integration
Authors: Ebraheem Yousef , Drean Emilie , Adolphe Dominique Charles 
Published: December 2020

PurposeThe paper aims to present the design, validation and integration of a universal fabric gripper. Flexible material handling is one of the most challenging problems occurring in the field of manipulator robots. Because textile products shape and properties can widely vary, each textile and each technological operation should have its own specialized gripper. The objective of the work described here is therefore to design a universal gripper able to grip and transfer every kind of textile.Design/methodology/approachThe design objectives are the ability to handle panels of varying shapes and sizes without material deformation and/or folding, and the easy integration with commercially available manipulator robots. To answer initial requirements and increase the textile gripping reliability, we opted to combine three different gripping technologies: vacuum, intrusion and pinch.FindingsEach system was first validated independently through static tests. The vacuum technology offers a high reliability to handle impermeable materials. The intrusion technology is reliable for the manipulation of high porosity materials, while the pinch technology shows good results for all soft fabrics when combined with the vacuum technology. Then, the limits of the new gripper in terms of gripping capacity, compressed air consumption and characteristics and limitations of the flexible material handled were put in evidence using a robot arm. An automated selection program of the gripper based on the material characteristics has also been developed and implemented.Originality/valueThis paper fulfills an identified need to design a universal gripper able to grip and transfer every different kind of cut textile.
Discrimination against refugees in the Palestinian labor market
Authors: Morrar Rabeh , Rios-Avila Fernando 
Published: December 2020

PurposeThis paper examines the level and structure of the wage inequality between nonrefugee and refugee workers in Palestine and the extent to which such wage gap reflects any marginalization and discrimination against refugees. It also investigates how the disparities in distribution to individual worker characteristics contribute to the wage inequality in Palestine.Design/methodology/approachThe authors use both Oaxaca and Blinder (OB) (Oaxaca, 1973 and Blinder, 1973) and Fortin et al. (2011) unconditional quantile decomposition approaches to measure the size of the wage gap along with the wage distribution and to decompose the wage differences into productivity (i.e. explained or the composition effects) and wage structure effects (i.e. unexplained or discrimination effects).FindingsResults indicate that most of the wage gap between refugees and nonrefugees is attributed to the wage structure effect (possibly explained by discrimination) against refugees in the Palestinian labor market. The wage gap between refugees and nonrefugees is not uniform throughout the wage distribution and supports the “sticky floor effect.”Practical implicationsThis work introduces important policy implications for the policymakers in the Palestinian labor market. It reveals the economic and social factors, individual worker characteristics as well as labor market characteristics contribute to the wage inequality in Palestine.Social implicationsThis research reveals a crucial social challenge in the Palestinian society, represented by the wage discrimination against refugees in Palestine. This is despite the denial of such discrimination from official bodies, local institutions and many other policymakers. It also captures gender inequality between men and women.Originality/valueThis is the first empirical work in Palestine that contends with a very sensitive issue in the Palestinian society, that is, the discrimination against refugees in the Palestinian labor market. Most of the existing studies have approached this issue from a humanitarian view in order to show the deterioration of social and economic situations in the refugee camps.
Supply chain sustainability: learning from the COVID-19 pandemic
Authors: Sarkis Joseph 
Published: December 2020

PurposeThis paper, a pathway, aims to provide research guidance for investigating sustainability in supply chains in a post-COVID-19 environment.Design/methodology/approachPublished literature, personal research experience, insights from virtual open forums and practitioner interviews inform this study.FindingsCOVID-19 pandemic events and responses are unprecedented to modern operations and supply chains. Scholars and practitioners seek to make sense of how this event will make us revisit basic scholarly notions and ontology. Sustainability implications exist. Short-term environmental sustainability gains occur, while long-term effects are still uncertain and require research. Sustainability and resilience are complements and jointly require investigation.Research limitations/implicationsThe COVID-19 crisis is emerging and evolving. It is not clear whether short-term changes and responses will result in a new “normal.” Adjustment to current theories or new theoretical developments may be necessary. This pathway article only starts the conservation – many additional sustainability issues do arise and cannot be covered in one essay.Practical implicationsOrganizations have faced a major shock during this crisis. Environmental sustainability practices can help organizations manage in this and future competitive contexts.Social implicationsBroad economic, operational, social and ecological-environmental sustainability implications are included – although the focus is on environmental sustainability. Emergent organizational, consumer, policy and supply chain behaviors are identified.Originality/valueThe authors take an operations and supply chain environmental sustainability perspective to COVID-19 pandemic implications; with sustainable representing the triple bottom-line dimensions of environmental, social and economic sustainability; with a special focus on environmental sustainability. Substantial open questions for investigation are identified. This paper sets the stage for research requiring rethinking of some previous tenets and ontologies.
Observations of deglobalization against globalization and impacts on global business
Authors: Kim Hag-Min , Li Ping , Lee Yea Rim 
Published: December 2020

PurposeThis study aims to investigate current deglobalization against globalization and to hypothesize reasons and drivers of deglobalization. In addition, the study suggests an empirical model to test whether deglobalization exists in the world economy. The consequences of deglobalization are discussed.Design/methodology/approachVarious measures for deglobalization are introduced for monitoring the deglobalization of a country, and statistical measures are reported. The research framework for deglobalization and empirical models are suggested. The relationship between deglobalization and globalization is being modeled using three KOF globalization indexes: economic, political and societal. This study used panel data from 1970 to 2017 for developed and developing countries to determine the degree of deglobalization.FindingsDeglobalization has been found empirically since the global financial crisis. Deglobalization is estimated by the decreasing trend of import share in a country's gross domestic product and is influenced by manufacturing imports, country's income divide and political globalization. Both economic and societal globalizations have negative influence on deglobalization. Deglobalization is more apparent in developed countries than in developing countries, and the deglobalization trend will continue in diverse formats.Research limitations/implicationsThis study limits the use of few variables to test the antecedents of deglobalization. Another study can be done to extend preceding variables and estimate the consequences of deglobalization, which may segregate the globalization effect. The international business executive should understand the complexity of deglobalization and consider business benefits and risks to be encountered.Originality/valueThis study used panel data from 1970 to 2017 for developed and developing countries to determine the degree of deglobalization.
Understanding drivers and outcomes of brand attachment in mobile branded apps
Authors: Tran Trang P. , Furner Christopher P. , Albinsson Pia A. 
Published: December 2020

Purpose
Mobile computing is an emerging trend. Building on motivational theories, brand attachment and mobile application literature, this paper tests a conceptual model with the aim to provide insights into antecedents and outcomes of consumer brand attachment in a mobile app context.

Design/methodology/approach
A model is developed in which antecedents and outcomes of brand attachment in a branded mobile app context are examined. Data collected from 228 mobile app users were analyzed using PLS-SEM.

Findings
The results confirm that hedonic motivation is positively associated with brand attachment. Nevertheless, the effects of utilitarian motivation and social motivation on brand attachment are not supported. As anticipated, brand attachment is positively associated with three outcomes, including continuance intention, purchase intention and word-of-mouth communication.

Originality/value
The paper extends the Mobile Application Stickiness paradigm by including brand characteristics, which had not previously been explored. Also, in terms of attachment in a mobile context, only affection has been explored; this study includes connection and passion to investigate how those components enhance desired outcomes.