bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Assessment of Aged Concrete Gravity Dam Subjected to Material Deterioration Under Seismic Excitation
Authors: Nahar Tahmina Tasnim , Cao Anh-Tuan , Kim Dookie 
Published: October 2020

AbstractThis paper proposes an approach to assess and predict the seismic risk of existing concrete gravity dams (CGDs) considering the ageing effect. The combination of fragility function and cumulative absolute velocity (CAV) depending on two failure states has been used in the analysis. It represents the time-variant degradation of the concrete structure and the conditional change of structural vulnerability in the case of the seismic excitation. Therefore, the seismic risk assessment captures here the nonlinear dynamic behavior of a concrete gravity dam through the fragility analysis. Incremental dynamic analysis for the fragility curves is adopted to state the performance of the dam in terms of different intensity measures. To assess the capacity of the aged concrete gravity dam, this research introduces a way to estimate the CAVlimit of CGDs with varying time. For a case study, an existing concrete gravity dam in Korea has been taken into consideration to apply this approach. The numerical finite element model is validated by optimizing the recorded field data. The proposed approach and its findings will be helpful to CGDs operators to ensure whether a dam needs to stop after a specific time using the extracted mathematical model. Furthermore, as this mathematical model is the function of time, the operator can get an idea about dam conditions at any specific time and can take necessary steps.
The effect of life coaching on psychological distress among dental students: interventional study
Authors: Aboalshamat Khalid , Al-Zaidi Duha , Jawa Duha , Al-Harbi Hanouf , Alharbi Raghad , Al-Otaibi Shahad 
Published: October 2020

AbstractBackgroundDepression, stress, and anxiety are common psychological conditions among dental students in many countries around the world. A number of researchers have found life coaching to be effective at reducing psychological distress. The aim of this study was to assess the effect of a life coaching program on dental students’ psychological status.MethodsA quasi-experiment study with two arms was conducted on 88 female dental students at Umm Al-Qura University (study group = 44; control group = 44). The psychological status was assessed by questionnaire before and after intervention. The questionnaire was composed of the Depression and Anxiety Stress Scale (DASS-21), Resilience Scale (RS-14), the Psychological Well-Being Scale–Short (PWB-S), and goal approach questions. The study group received a coaching program comprising one lecture for 1 h and five phone coaching sessions over 5 weeks, while the control group received no intervention.ResultsThe study group showed a significant reduction in depression, anxiety, stress, resilience, and self-acceptance according to the PWB-S scale. Also, goal approach was significantly improved. On the other hand, the control group showed a significant reduction on the RS-14 only. The differences in the tested scales between the study group and the control group from pre-intervention (T1) to post-intervention (T2) showed significant differences in depression, stress, self-acceptance, and goal approach measurements per t-test.ConclusionThe study’s findings showed that life coaching had the effect of reducing psychological distress, which encouraged the implementation of coaching practice in the daily life of dental students.
Oxygen administration for postoperative surgical patients: a narrative review
Authors: Suzuki Satoshi 
Published: October 2020

AbstractMost postoperative surgical patients routinely receive supplemental oxygen therapy to prevent the potential development of hypoxemia due to incomplete lung re-expansion, reduced chest wall, and diaphragmatic activity caused by surgical site pain, consequences of hemodynamic impairment, and residual effects of anesthetic drugs (most notably residual neuromuscular blockade), which may result in atelectasis, ventilation–perfusion mismatch, alveolar hypoventilation, and impaired upper airway patency. Additionally, the World Health Organization guidelines for reducing surgical site infection have recommended the perioperative administration of high-dose oxygen, including during the immediate postoperative period. However, supplemental oxygen and hyperoxemia also have harmful effects on the respiratory and cardiovascular systems, with several clinical studies having reported an association between high perioperative oxygen administration and worse clinical outcomes. Recently, the increased availability of new and short-acting anesthetic drugs, comprehensive pharmacological knowledge, postoperative multimodal analgesia, and new minimally invasive surgery options could result in lower incidences of postoperative hypoxemia. Moreover, recommendations promoting high oxygen administration to prevent surgical site infections have been challenged, considering the lack of scientific investigations, and have not been widely accepted. Given the potential harmful effects of hyperoxemia, routine postoperative oxygen administration might not be recommended. Recent clinical studies have indicated that a conservative approach to oxygen therapy, where oxygen administration is titrated to achieve slightly lower oxygen levels than usual, could be safely implemented and decrease acutely ill patients’ susceptibility to hyperoxemia. Based on current evidence, appropriate monitoring, including peripheral oxygen saturation, and oxygen titration should be required during postoperative oxygen administration to avoid both hypoxemia and hyperoxemia. Future trials should therefore focus on determining the optimal oxygen target during postoperative care.
Autogenous bone augmentation from the zygomatic alveolar crest: a volumetric retrospective analysis in the maxilla
Authors: Kuster Irina , Osterwalder Livia , Valdec Silvio , Stadlinger Bernd , Wagner Maximilian E. H. , Rücker Martin , Bichsel Dominique 
Published: October 2020

Abstract
Background
Autogenous bone augmentation is the gold standard for the treatment of extended bone defects prior to implantation. Bone augmentation from the zygomatic crest is a valuable option with several advantages, but the current literature for this treatment is scant. The aim of this study was to evaluate the increase in bone volume after locoregional bone augmentation using autogenous bone from the zygomatic alveolar crest as well as the complications and success rate.

Results
Analysis of the augmented bone volume in seven patients showed a maximum volume gain of 0.97 cm3. An average of 0.54 cm3 of autogenous bone (SD 0.24 cm3; median: 0.54 cm3) was augmented. Implantation following bone augmentation was possible in all cases. Complications occurred in three patients.

Conclusion
The zygomatic alveolar crest is a valuable donor site for autogenous alveolar onlay grafting in a locoregional area such as the maxillary front. Low donor site morbidity, good access, and its suitable convexity make it a beneficial choice for autogenous bone augmentation.
Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage
Authors: Wu Xiaoling , Zhong Youwen , Chen Qing , Zhang Xin , Zhang Hua 
Published: October 2020

Abstract
Background
Cervical cancer (CC) is the third most common gynecological malignancy around the world. Cisplatin is an effective drug, but cisplatin resistance is a vital factor limiting the clinical usage of cisplatin. Enhancer of mRNA decapping protein 4 (EDC4) is a known regulator of mRNA decapping, which was related with genome stability and sensitivity of drugs. This research was to investigate the mechanism of EDC4 on cisplatin resistance in CC. Two human cervical cancer cell lines, HeLa and SiHa, were used to investigate the role of EDC4 on cisplatin resistance in vitro. The knockdown or overexpression of EDC4 or replication protein A (RPA) in HeLa or SiHa cells was performed by transfection. Cell viability was analyzed by MTT assay. The growth of cancer cells was evaluated by colony formation assay. DNA damage was measured by γH2AX (a sensitive DNA damage response marker) immunofluorescent staining. The binding of EDC4 and RPA was analyzed by immunoprecipitation.

Results
EDC4 knockdown in cervical cancer cells (HeLa and SiHa) enhanced cisplatin sensitivity and cisplatin induced cell growth inhibition and DNA damage. EDC4 overexpression reduced DNA damage caused by cisplatin and enhanced cell growth of cervical cancer cells. EDC4 could interact with RPA and promote RPA phosphorylation. RPA knockdown reversed the inhibitory effect of EDC4 on cisplatin-induced DNA damage.

Conclusion
The present results indicated that EDC4 is responsible for the cisplatin resistance partly through interacting with RPA in cervical cancer by alleviating DNA damage. This study indicated that EDC4 or RPA may be novel targets to combat chemotherapy resistance in cervical cancer.

Graphical abstract
Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells
Authors: Han Nanumi , Anwar Delnur , Hama Naoki , Kobayashi Takuto , Suzuki Hidefumi , Takahashi Hidehisa , Wada Haruka , Otsuka Ryo , Baghdadi Muhammad , Seino Ken-ichiro 
Published: October 2020

Abstract
Background
Interleukin (IL)-34 acts as an alternative ligand for the colony-stimulating factor-1 receptor and controls the biology of myeloid cells, including survival, proliferation, and differentiation. IL-34 has been reported to be expressed in cancer cells and to promote tumor progression and metastasis of certain cancers via the promotion of angiogenesis and immunosuppressive macrophage differentiation. We have shown in our previous reports that targeting IL-34 in chemo-resistant tumors in vitro resulted in a remarkable inhibition of tumor growth. Also, we reported poor prognosis in patients with IL-34-expressing tumor. Therefore, blocking of IL-34 is considered as a promising therapeutic strategy to suppress tumor progression. However, the molecular mechanisms that control IL-34 production are still largely unknown.

Methods
IL-34 producing ovarian cancer cell line HM-1 was treated by bromodomain and extra terminal inhibitor JQ1. The mRNA and protein expression of IL-34 was evaluated after JQ1 treatment. Chromatin immunoprecipitation was performed to confirm the involvement of bromodomain-containing protein 4 (Brd4) in the regulation of the Il34 gene. Anti-tumor effect of JQ1 was evaluated in mouse tumor model.

Results
We identified Brd4 as one of the critical molecules that regulate Il34 expression in cancer cells. Consistent with this, we found that JQ1 is capable of efficiently suppressing the recruitment of Brd4 to the promotor region of Il34 gene. Additionally, JQ1 treatment of mice bearing IL-34-producing tumor inhibited the tumor growth along with decreasing Il34 expression in the tumor.

Conclusion
The results unveiled for the first time the responsible molecule Brd4 that regulates Il34 expression in cancer cells and suggested its possibility as a treatment target.
The Treatment-induced Neuropathy Assessment Scale (TNAS): a psychometric update following qualitative enrichment
Authors: Mendoza Tito R. , Williams Loretta A. , Shi Qiuling , Wang Xin Shelley , Bamidele Oluwatosin , Woodruff Jeanie F. , Cleeland Charles S. 
Published: October 2020

Abstract
Background
The validation of the Treatment-induced Neuropathy Assessment Scale (TNAS v2.0), a patient-reported outcome measure of symptoms associated with cancer treatment-induced peripheral neuropathy (TIPN), was previously reported. Further patient input (qualitative interviewing, cognitive debriefing) suggested that the measure should be modified to better reflect the TIPN experience. We report the performance of a revised version (TNAS v3.0) for assessing TIPN across cancer treatments. This TNAS version incorporates extensive patient input, in accordance with FDA guidance on the development of patient-reported outcomes measures. Patients with multiple myeloma, colorectal cancer, or gynecological cancer treated with bortezomib, oxaliplatin, or taxane–platinum combination therapy, respectively, completed the TNAS v3.0, European Organization for Research and Treatment of Cancer Chemotherapy-Induced Peripheral Neuropathy (EORTC-CIPN20), and a cognitive debriefing survey during a scheduled clinic visit. Patients also participated in in-depth qualitative interviews about their TIPN symptoms. The psychometric properties of the TNAS v3.0 were evaluated.

Results
Cognitive debriefing survey results were summarized and showed that most patients found the items easy to complete, comprehensible, acceptable, and not redundant. A notable change from TNAS v2.0 was the separation of “numbness” from “tingling,” although these 2 items remained the most severe, followed by a new “pain” item. The Cronbach coefficient alphas for the 9-item TNAS were 0.88 and 0.90 at the first and second administrations, respectively, indicating good reliability. The test–retest reliability of the TNAS was 0.97. The correlation coefficients for the 9-item TNAS and the EORTC-CIPN20 were 0.69 for the sensory subscale, 0.70 for the motor subscale, and 0.32 for the autonomic subscale, indicating good validity.

Conclusion
This psychometric evaluation showed that the TNAS v3.0 is valid and reliable. Further research is needed to determine clinically meaningful differences in TNAS v3.0 scores and demonstrate its responsiveness over time.
E-consults: an effective way to decrease clinic wait times in rheumatology
Authors: Patel Veena , Stewart Diana , Horstman Molly J. 
Published: October 2020

Abstract
Background
To evaluate the effect of E-consults on wait times and resource utilization for positive antinuclear antibody (ANA) referrals in outpatient rheumatology.

Methods
We conducted a pre-post study of E-consult implementation for positive ANA referrals. We retrospectively reviewed “positive ANA” referrals from 1/2015–3/2017. A statistical process control chart was created to display monthly average wait times for in-person clinic visits and to identify special cause variation. Final diagnoses, wait times and resource utilization were recorded and compared between E-consults and in-person referrals.

Results
There were 139 referrals for positive ANA with 126 occurring after E-consult implementation in August 2015. Forty-four percent (55/126) of referrals were E-consults; 76% did not have an in-person visit after initial electronic rheumatology recommendation. A control chart demonstrated special cause variation in the form of a shift from June 2016 – January 2017, suggesting a temporal association between decreased wait times and the implementation of E-consults. Eleven patients were diagnosed with ANA-associated rheumatic disease; the majority of patients (73%, 86/139) did not have a rheumatologic diagnosis. Overall E-consults utilized more labs than in-person visits, but this was not statistically significant. In-person visits utilized more imaging studies, which was statistically significant.

Conclusion
E-consults are an effective way to address positive ANA consults without significant increase in resource utilization and were temporally associated with decreased wait times for in-person visits.
Life table and demographic parameters of the coccinellid predatory species, Hippodamia convergens Guérin-Méneville (Coleoptera: Coccinellidae) when fed on two aphid species
Authors: Arshad Muhammad , Ullah Muhammad Irfan , Shahid Umair , Tahir Muhammad , Khan Malik Imran , Rizwan Muhammad , Abrar Muhammad , Niaz Muhammad Mubashar 
Published: October 2020

AbstractThe study aimed to determine the effect of two aphid species; Lipaphis erysimi (Kaltenbach) and Aphis gossypii Glover (Hemiptera: Aphididae) on life table and demographic parameters of Hippodamia convergens Gu`erin-M´eneville (Coleoptera: Coccinellidae). The developmental period of all life stages of H. convergens was shorter when fed on L. erysimi. Net reproductive rate (Ro) was higher (159.85 offspring/individual) on L. erysimi, while it was 87.85 offspring/individual on A. gossypii. Mean generation time (T) was shorter (30.49 d) on L. erysimi than on A. gossypii (45.1 days). Values of the intrinsic rate of increase (r) and finite rate of increase (λ) were calculated as 0.166 days−1 and 1.181 days−1, respectively, on L. erysimi that were higher than on A. gossypii (0.099 days−1 and 1.104 days−1, respectively). Similarly, the survival rate was also higher when the predator was fed on L. erysimi. Overall, the findings suggest using L. erysimi as a better source of prey than A. gossypii for rearing H. convergens.
Lentiform fork sign in a uremic patient with a high anion gap metabolic acidosis with seizures: a case report from North West of Ireland
Authors: Mansoor Salman , De Klerk Lize , Lineen James , Fahad Muhammad , Ali Imran , Coffey Barry , Mulry Monica Ann , Saadat Shoab , Kelly Siobhan , Adenan Mohammad Hijaz , Murphy Kevin 
Published: October 2020

AbstractBackgroundLentiform fork sign is a neuroradiological abnormality which is encountered in the clinical practice associated with uremic encephalopathy, dialysis disequilibrium syndrome and metabolic acidosis.Case presentationWe describe here a case of this neuro-radiological abnormality which was encountered in a patient with uraemia and high anion gap metabolic acidosis who presented with generalised convulsion and later had some tremor in her hands. In our patient, there were few predisposing factors which might have possibly resulted in this abnormality chronic kidney disease, diabetes mellitus, and metabolic acidosis.ConclusionThe Lentiform fork sign is a rare occurrence which can be related to a long list of toxic and metabolic causes but in conjunction with metabolic acidosis in chronic kidney disease patients, it can narrow down this list of alternate diagnosis.
Effect of contamination sources on the rate of zinc, copper and nickel release from various soil ecosystems
Authors: Mansour Hesham , Awad Fikry , Saber Mohamed , Zaghloul Alaa 
Published: October 2020

Abstract
Background and objective
Soil is a substantive component in biosphere habitually endangered to superfluity contaminants particularly potential toxic elements (PTEs). The source of soil contaminants is very critical in controlling both their release and expected hazards in the different soil ecosystems. This study aims to investigate the effect of low-quality irrigation water (LQW) on the extent of soil pollution through desorption of zinc (Zn), nickel (Ni) and copper (Cu) from different polluted soils, collected from LQW irrigated farms for more than 40–80 years at Giza and Kafr-Elsheikh Governorates, Egypt.

Results
Models incorporated modified Freundlich (MFE), Elovich, first order and parabolic diffusion (PDE) showed significant results in describing the kinetic data under Egyptian conditions. Results entailed that according to the coefficient of determination (R2) and standard error, all used models well described the desorption of Cu, Ni and Zn, the most prevalent contaminants in the trailed soil ecosystems; for example, the R2 values were higher than 0.96** for zinc desorption using MFE model. As far as the PTEs levels are considered, the highest contaminant desorption rates were recorded at Kafr-Elsheikh site, followed by Kombora, and the lowest ones were in Abo Rawash soil ecosystem. The succession of more than one model to describe the kinetic perspective confirmed that the different mechanisms take place in PTEs sorption, distribution and subsequently release from different soil ecosystems.

Conclusions
The numerical values indicated that the soil ecosystems contaminated with industrial effluents were higher than those irrigated with sewage effluents regardless of the type of land use. More attention should be paid to low-quality water application in agriculture irrigation and its environmental risks.
Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans
Authors: Vazquez-Munoz Roberto , Arellano-Jimenez M. Josefina , Lopez-Ribot Jose L. 
Published: October 2020

Abstract
Background
Bismuth compounds are known for their activity against multiple microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain poorly explored. The objective of this work is to further the research of BiNPs for nanomedicine-related applications. Stable Polyvinylpyrrolidone (PVP)-coated BiNPs were produced by a chemical reduction process, in less than 30 min.

Results
We produced stable, small, spheroid PVP-coated BiNPs with a crystalline organization. The PVP-BiNPs showed potent antibacterial activity against the pathogenic bacterium Staphylococcus aureus and antifungal activity against the opportunistic pathogenic yeast Candida albicans, both under planktonic and biofilm growing conditions.

Conclusions
Our results indicate that BiNPs represent promising antimicrobial nanomaterials, and this facile synthetic method may allow for further investigation of their activity against a variety of pathogenic microorganisms.
A novel suprachoroidal microinvasive glaucoma implant: in vivo biocompatibility and biointegration
Authors: Grierson Ian , Minckler Don , Rippy Marian K. , Marshall Andrew J. , Collignon Nathalie , Bianco Jessica , Detry Benoit , Johnstone Murray A. 
Published: October 2020

Abstract
Background
A major challenge for any glaucoma implant is their ability to provide long-term intraocular pressure lowering efficacy. The formation of a low-permeability fibrous capsule around the device often leads to obstructed drainage channels, which may impair the drainage function of devices. These foreign body-related limitations point to the need to develop biologically inert biomaterials to improve performance in reaching long-term intraocular pressure reduction. The aim of this study was to evaluate in vivo (in rabbits) the ocular biocompatibility and tissue integration of a novel suprachoroidal microinvasive glaucoma implant, MINIject™ (iSTAR Medical, Wavre, Belgium).

Results
In two rabbit studies, no biocompatibility issue was induced by the suprachoroidal, ab-externo implantation of the MINIject™ device. Clinical evaluation throughout the 6 post-operative months between the sham and test groups were similar, suggesting most reactions were related to the ab-externo surgical technique used for rabbits, rather than the implant material itself. Histological analysis of ocular tissues at post-operative months 1, 3 and 6 revealed that the implant was well-tolerated and induced only minimal fibroplasia and thus minimal encapsulation around the implant. The microporous structure of the device became rapidly colonized by cells, mostly by macrophages through cell migration, which do not, by their nature, impede the flow of aqueous humor through the device. Time-course analysis showed that once established, pore colonization was stable over time. No fibrosis nor dense connective tissue development were observed within any implant at any time point. The presence of pore colonization may be the process by which encapsulation around the implant is minimized, thus preserving the permeability of the surrounding tissues. No degradation nor structural changes of the implant occurred during the course of both studies.

Conclusions
The novel MINIject™ microinvasive glaucoma implant was well-tolerated in ocular tissues of rabbits, with observance of biointegration, and no biocompatibility issues. Minimal fibrous encapsulation and stable cellular pore colonization provided evidence of preserved drainage properties over time, suggesting that the implant may produce a long-term ability to enhance aqueous outflow.