bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐run net returns to a cereal rye cover crop mix in a midwest corn–soybean rotation
Authors: Thompson Nathanael M. , Armstrong Shalamar D. , Roth Richard T. , Ruffatti Michael D. , Reeling Carson J. 
Published: March 2020

AbstractUnsubstantiated economic returns are a major contributor to producers’ reluctance to adopt cover crops. The objective of this study is to evaluate the direct short‐run net returns to the producer of implementing a predominantly cereal rye (Secale cereal L.) cover crop mix into a Midwest corn (Zea mays L.)–soybean [Glycine max (L.) Merr.] rotation. Experimental agronomic data from field experiments in Lexington, IL, are used to calibrate economic simulations of the costs and benefits of cover crop adoption. Results indicate that net returns to cover crops, including current cost‐share payments, were routinely negative. Returns to the soybean phase of the rotation were higher than corn given that the cover crop significantly reduced corn yield in 1 of 2 yr but did not significantly affect soybean yield. A scenario where cover crop biomass was hypothetically harvested and valued as a livestock feedstuff increased returns. However, further research is needed to validate the agronomic assumptions underlying this scenario. Finally, the breakeven subsidy that would make the producer indifferent to planting cover crops was estimated to be US$13–$23 kg–1 of nitrate saved from leaving the field each year (or approximately $195–$345 ha–1). This is higher than current cost‐share payments ($140 ha–1). In the short‐run, incentivizing producers to adopt cover crops will likely require (i) improved recommendations for cover crop best management practices to eliminate current downside risk and (ii) higher cost‐share payments or established markets to internalize cover crop benefits that accrue to society.
Brain morphological analysis in PTEN hamartoma tumor syndrome
Authors: Shiohama Tadashi , Levman Jacob , Vasung Lana , Takahashi Emi 
Published: March 2020

AbstractPTEN hamartoma tumor syndrome (PHTS) is a spectrum of hereditary cancer syndromes caused by germline mutations in PTEN. PHTS is of high interest, because of its high rate of neurological comorbidities including macrocephaly, autism spectrum disorder, and intellectual dysfunction. Since detailed brain morphology and connectivity of PHTS remain unclear, we quantitatively evaluated brain magnetic resonance imaging (MRI) in PHTS. Sixteen structural T1‐weighted and 9 diffusion‐weighted MR images from 12 PHTS patients and neurotypical controls were used for structural and high‐angular resolution diffusion MRI (HARDI) tractography analyses. Mega‐corpus callosum was observed in 75%, polymicrogyria in 33%, periventricular white matter lesions in 83%, and heterotopia in 17% of the PHTS participants. While gyrification index and hemispheric cortical thickness showed no significant differences between the two groups, significantly increased global and regional brain volumes, and regionally thicker cortices in PHTS participants were observed. HARDI tractography showed increased volume and length of callosal pathways, increased volume of the arcuate fasciculi (AF), and increased length of the bilateral inferior longitudinal fasciculi (ILF), bilateral inferior fronto‐occipital fasciculi (IFOF), and bilateral uncinate fasciculus. A decrease in fractional anisotropy and an increased in apparent diffusion coefficient values of the AF, left ILF, and left IFOF in PHTS.
Clinical versus automated assessments of morphological variants in twins with and without neurodevelopmental disorders
Authors: Myers Lynnea , Anderlid Britt‐Marie , Nordgren Ann , Lundin Karl , Kuja‐Halkola Ralf , Tammimies Kristiina , Bölte Sven 
Published: March 2020

AbstractPhysical examinations are recommended as part of a comprehensive evaluation for individuals with neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD) and attention–deficit/hyperactivity disorder. These examinations should include assessment for morphological variants. Previous studies have shown an increase in morphological variants in individuals with NDDs, particularly ASD, and that these variants may be present in greater amounts in individuals with genetic alterations. Unfortunately, assessment for morphological variants can be subjective and time‐consuming, and require a high degree of clinical expertise. Therefore, objective, automated methods of morphological assessment are desirable. This study compared the use of Face2Gene, an automated tool to explore facial morphological variants, to clinical consensus assessment, using a cohort of N = 290 twins enriched for NDDs (n = 135 with NDD diagnoses). Agreement between automated and clinical assessments were satisfactory to complete (78.3–100%). In our twin sample, individuals with NDDs did not have greater numbers of facial morphological variants when compared to those with typical development, nor when controlling for shared genetic and environmental factors within twin pairs. Common facial morphological variants in those with and without NDDs were similar and included thick upper lip vermilion, abnormality of the nasal tip, long face, and upslanted palpebral fissure. We conclude that although facial morphological variants can be assessed reliably in NDDs with automated tools like Face2Gene, clinical utility is limited when just exploring the facial region. Therefore, currently, automated assessments may best complement, rather than replace, in‐person clinical assessments.
An eco‐friendly method based on the self‐glue effect of keratins for preparing Fe3O4‐coated wool
Authors: Zhao Zhenyun , Song Chi , Zhou Jing , Hu Ruimin , Xiao Hang , Liu Yiping , Lu Ming 
Published: March 2020

AbstractAlthough coating technology and in‐situ synthesis have been widely applied to produce Fe3O4 NPs‐containing composite materials, there still exist potential risks to the environment. Herein, an eco‐friendly preparation of Fe3O4 nanoparticles (FNPs)‐coated wool felt is proposed based on the self‐glue effect of wool keratins in the NaHSO3/urea solution. It avoids the use of coating agents, and also the commercially available FNPs are directly utilized as raw materials, both making the residual FNPs completely recyclable. The resulting FNPs‐coated wool felt shows high magnetization (23.54 emu g−1) and excellent microwave‐assisted heating properties (the temperature rise is about 40°C after 10 min). The results of EDS‐SEM (energy dispersive spectrometer‐scanning electron microscope), loud amount (%), crease recovery angle (CRA), Fourier transform infrared (FTIR) spectrometer and X‐ray diffraction (XRD) prove that the dramatical swelling and the recoagulation of superficial keratins of wool fibers are the mechanism of the self‐glue effect.
Did Acidic Stress Resistance in Vertebrates Evolve as Na+/H+ Exchanger‐Mediated Ammonia Excretion in Fish?
Authors: Tseng Yung‐Che , Yan Jia‐Jiun , Furukawa Fumiya , Hwang Pung‐Pung 
Published: March 2020

AbstractHow vertebrates evolved different traits for acid excretion to maintain body fluid pH homeostasis is largely unknown. The evolution of Na+/H+ exchanger (NHE)‐mediated NH4+ excretion in fishes is reported, and the coevolution with increased ammoniagenesis and accompanying gluconeogenesis is speculated to benefit vertebrates in terms of both internal homeostasis and energy metabolism response to acidic stress. The findings provide new insights into our understanding of the possible adaptation of fishes to progressing global environmental acidification. In human kidney, titratable H+ and NH4+ comprise the two main components of net acid excretion. V‐type H+‐ATPase‐mediated H+ excretion may have developed in stenohaline lampreys when they initially invaded freshwater from marine habitats, but this trait is lost in most fishes. Instead, increased reliance on NHE‐mediated NH4+ excretion is gradually developed and intensified during fish evolution. Further investigations on more species will be needed to support the hypothesis. Also see the video abstract here https://youtu.be/vZuObtfm-34.
Timing of procedural stroke and death in asymptomatic patients undergoing carotid endarterectomy: individual patient analysis from four RCTs
Authors: Poorthuis M H F , Bulbulia R , Morris D R , Pan H , Rothwell P M , Algra A , Becquemin J-P , Bonati L H , Brott T G , Brown M M , Calvet D , Eckstein H-H , Fraedrich G , Gregson J , Greving J P , Hendrikse J , Howard G , Jansen O , Mas J-L , Lewis S C , de Borst G J , Halliday A 
Published: March 2020

Abstract

Background
The effectiveness of carotid endarterectomy (CEA) for stroke prevention depends on low procedural risks. The aim of this study was to assess the frequency and timing of procedural complications after CEA, which may clarify underlying mechanisms and help inform safe discharge policies.

Methods
Individual-patient data were obtained from four large carotid intervention trials (VACS, ACAS, ACST-1 and GALA; 1983–2007). Patients undergoing CEA for asymptomatic carotid artery stenosis directly after randomization were used for the present analysis. Timing of procedural death and stroke was divided into intraoperative day 0, postoperative day 0, days 1–3 and days 4–30.

Results
Some 3694 patients were included in the analysis. A total of 103 patients (2·8 per cent) had serious procedural complications (18 fatal strokes, 68 non-fatal strokes, 11 fatal myocardial infarctions and 6 deaths from other causes) [Correction added on 20 April, after first online publication: the percentage value has been corrected to 2·8]. Of the 86 strokes, 67 (78 per cent) were ipsilateral, 17 (20 per cent) were contralateral and two (2 per cent) were vertebrobasilar. Forty-five strokes (52 per cent) were ischaemic, nine (10 per cent) haemorrhagic, and stroke subtype was not determined in 32 patients (37 per cent). Half of the strokes happened on the day of CEA. Of all serious complications recorded, 44 (42·7 per cent) occurred on day 0 (20 intraoperative, 17 postoperative, 7 with unclear timing), 23 (22·3 per cent) on days 1–3 and 36 (35·0 per cent) on days 4–30.

Conclusion
At least half of the procedural strokes in this study were ischaemic and ipsilateral to the treated artery. Half of all procedural complications occurred on the day of surgery, but one-third after day 3 when many patients had been discharged.
Neural characteristics of cognitive reappraisal success and failure: An ERP study
Authors: Cao Dan , Li Yingjie , Niznikiewicz Margaret A. 
Published: March 2020

AbstractIntroductionCognitive reappraisal, an important strategy of emotion regulation, can change emotional experience and attention to emotional information. However, not all individuals can deploy reappraisal strategies successfully. In the current study, we investigated event‐related potential (ERP) characteristics of reappraisal success and of reappraisal failure.MethodsTwenty‐six participants were divided into the success group or the failure group based on self‐report ratings of how successful they were in reducing their response to negative images using cognitive reappraisal strategy. All participants viewed 30 neutral images and 30 negative images which they were asked to just watch, and 30 negative stimuli that they were asked to reappraise, while electroencephalogram (EEG) was recorded.ResultsThe success group reported a significant reduction in the unpleasantness of negative images than the failure group in the negative‐reappraisal condition. The ERP data indicated that two time windows differentiated between the success and failure groups. In 200–300 ms, P200 was significantly more positive to the negative‐watch condition relative to both negative‐reappraisal and neutral conditions in the failure group, while no difference was observed in the success group. In 300–5,000 ms, cognitive reappraisal led to increased late positive potential (LPP) relative to negative‐watch in the early and middle latency windows (300–3,100 ms) in both groups; in the late latency window (3,100–5,000 ms), the reappraisal success group showed the LPP amplitude to the negative‐reappraisal stimuli to be more positive than to the negative‐watch stimuli, while no difference was found in the reappraisal failure group.ConclusionOur study provided direct evidence that different neurophysiological features were associated with reappraisal success and failure while engaging in the reappraisal of negative stimuli. This result will contribute to better understanding of the neural mechanism of emotion regulation in emotional disorders (i.e., depression and anxiety).
Can entrepreneurial orientation improve sustainable development through leveraging internal lean practices?
Authors: Chavez Roberto , Yu Wantao , Sadiq Jajja Muhammad Shakeel , Lecuna Antonio , Fynes Brian 
Published: March 2020

AbstractThis study aims to examine the mediating role of internal lean practices (ILPs) on the relationship between entrepreneurial orientation and triple bottom line performance (i.e. environmental, social, and operational performance). We examine Chile, which represents a vibrant economy and one of the world's most productive entrepreneurship ecosystems but with a history of socio‐economic inequalities and strong profit‐driven pressures to overextract natural resources. The study is based on a questionnaire related to manufacturing sent to 112 companies in Chile. The proposed relationships are analysed through structural equation modelling. The results indicate that ILPs fully mediate the effect of entrepreneurial orientation on environmental performance and social performance and partially mediates the effect of entrepreneurial orientation on operational performance. Our study extends the literature by explaining that entrepreneurial orientation builds and strengthens ILPs for creating triple bottom line competitive advantage.
Effects of awe on consumer preferences for healthy versus unhealthy food products
Authors: Cao Fei , Wang Xia , Wang Ze 
Published: March 2020

AbstractThis research investigates how a discrete positive emotion (awe) impacts consumers' decisions on food choices. We probe and demonstrate that the experience of awe enhances consumer preferences for healthy versus unhealthy products. In a series of three studies, we find that awe, compared with a neutral emotion, increases consumers' likelihood to choose healthy products over unhealthy products (Study 1). Consumers' processing styles drive the observed awe effect (Study 2), whereby awe increases reliance on analytic processing, which leads to preferences for healthy products. Moreover, the experience of awe exerts a stronger influence on product choices among consumers with a chronic intuitive rather than analytic processing style (Study 3). Theoretical contributions to the research on awe, information processing, and healthy food preference, as well as practical implications for consumers and marketers, are discussed.
Therapeutic drug monitoring in peritoneal dialysis: A case of nontuberculous mycobacterium catheter‐related infection treated with amikacin
Authors: Kojya Sanae , Shiohira Hideo , Sunagawa Yoshitsugu , Tsuneyoshi Shoji , Kohagura Kentaro , Ohya Yusuke , Yonaha Fusako , Hokama Nobuo , Nakamura Katsunori 
Published: March 2020

AbstractThe pharmacokinetics of amikacin makes it difficult to predict the appropriate dosing to avoid harmful side effects in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The implementation of therapeutic drug monitoring may be useful in controlling amikacin serum concentrations in patients receiving CAPD.
Electrochemical CO oxidation by a Rh tetraaza[14]annulene‐based catalyst
Authors: Yamazaki Shin‐ichi , Asahi Masafumi , Siroma Zyun , Ioroi Tsutomu 
Published: March 2020

AbstractElectrochemical CO oxidation catalyzed by Rh complexes of tetraaza[14]annulene was examined. Rh complexes on carbon black exhibit much higher CO oxidation activity than Rh porphyrins or conventional Pt alloy catalysts. The onset potential for CO oxidation is lower than 0 V vs. a reversible hydrogen electrode. As a result, a combination of electrochemical CO oxidation by Rh tetraaza[14]annulene and proton reduction by Pt catalysts generates slight electricity. The combined overall reaction is a water‐gas shift reaction (CO+H2O→CO2+H2). The co‐presence of Rh tetraaza[14]annulene catalyst and Pt catalyst promotes the water‐gas shift reaction.
Partial Seeding Policy for Controlling the Crystal Quality in Batch Cooling Crystallization
Authors: Unno Joi , Hirasawa Izumi 
Published: March 2020

AbstractPartial seeding, in which the nuclei originating from seed crystals grow to yield the product crystals, was simulated and optimized for controlling the batch cooling crystallization process of L‐arginine. The product quality was evaluated by the coefficient of variation (CV) of the crystal size distribution. First, the optimum seed amount for partial seeding was estimated by simulation. Then, the simulated values of the optimum seed amount and the resulting local minimum CV were correlated with the seed crystal size and the cooling rate. The correlation can be utilized for estimating the seed amount in the case that the seed crystals are added in a slurry. Finally, these simulated values were compared to the measured ones. Consequently, the optimum seed amount was suggested to be reasonably predicted.
Controllable Synthesis of Leaf‐Like CuO Nanosheets for Selective CO2 Electroreduction to Ethylene
Authors: Tan Zhonghao , Peng Tingyue , Tan Xiaojie , Wang Wenhang , Wang Xiaoshan , Yang Zhongxue , Ning Hui , Zhao Qingshan , Wu Mingbo 
Published: March 2020

AbstractThe carbon dioxide reduction reaction (CO2RR) driven by renewable electricity is a promising way to tackle the CO2 emission woes and recycle use of CO2. The synthesis of electrocatalysts with high activity and selectivity for CO2RR to ethylene remains a great challenge. Herein, leaf‐like CuO nanosheets are fabricated in situ on nitrogen‐doped graphene (NG) by using a novel reduction‐oxidation‐reconstruction process. When used as a catalyst for the CO2RR in 0.1 M KHCO3, a high faradaic efficiency of approximately 30 % for ethylene with an ultra‐high ethylene/methane ratio of 190 was achieved at −1.3 V vs. the reversible hydrogen electrode. The SEM and TEM images confirm the leaf‐like CuO nanosheets display high‐curvature structures, while multiple distinguished grain boundaries constructed by CuO(110) and CuO(111) planes are verified by HRTEM. For the first time, we present a facile method to combine the high‐curvature structure and the grain boundary to enhance the selectivity of the CO2RR to ethylene over a CuO catalyst.
Allosteric p97 Inhibitors Can Overcome Resistance to ATP‐Competitive p97 Inhibitors for Potential Anticancer Therapy
Authors: Wang. Feng , Li Shan , Gan Taiping , Stott Gordon M. , Flint Andrew , Chou Tsui‐Fen 
Published: March 2020

AbstractAbstract: A major challenge of targeted cancer therapy is the selection for drug‐resistant mutations in tumor cells leading to loss of treatment effectiveness. p97/VCP is central regulator of protein homeostasis and a promising anticancer target because of its vital role in cell growth and survival. One ATP‐competitive p97 inhibitor, CB‐5083, has entered clinical trials. Selective pressure on HCT116 cells dosed with CB‐5083 identified five different resistant mutants. Identification of p97 inhibitors with different mechanisms of action would offer the potential to overcome this class of resistance mutations. Our results demonstrate that two CB‐5083 resistant p97 mutants, N660 K and T688 A, were also resistant to several other ATP‐competitive p97 inhibitors, whereas inhibition by two allosteric p97 inhibitors NMS‐873 and UPCDC‐30245 were unaffected by these mutations. We also established a CB‐5083 resistant cell line that harbors a new p97 double mutation (D649 A/T688 A). While CB‐5083, NMS‐873, and UPCDC‐30245 all effectively inhibited proliferation of the parental HCT116 cell line, NMS‐873 and UPCDC‐30245 were 30‐fold more potent in inhibiting the CB‐5083 resistant D649 A/T688 A double mutant than CB‐5083. Our results suggest that allosteric p97 inhibitors are promising alternatives when resistance to ATP‐competitive p97 inhibitors arises during anticancer treatment.
Reduction‐Triggered Doxorubicin Delivery by Self‐Assembled Nanospheres of Lipoylated Caffeine
Authors: Kumar Krishan , Kumar Shyamlal Bharti Rajesh , Verma Rajbala , Kondaiah Paturu , Chaudhary Sandeep 
Published: March 2020

AbstractThis study reports a new amphiphilic bioconjugate (CAFF‐LA) derived from the lipoylation of a hydroxyethyl derivative of caffeine. In water, CAFF‐LA self‐assembles into nanospheres with an average size of 155 nm, as evidenced from dynamic light scattering and electron microscopy studies. The nanospheres are stable in serum and could be disintegrated upon exposure to the reducing environment of dithiothreitol (DTT; 10 mM) and glutathione (GSH; 10 mM). These nanospheres easily encapsulate the chemotherapy medication, doxorubicin (DOX), and demonstrate an efficacious transport into doxorubicin‐resistant cervical cancer (HeLa) cells, wherein a marked induction in apoptosis and significantly lower IC50 have been observed when compared to that of free drug. The in vitro assessment of cell viability and hemocompatibility present these nanospheres as potentially safe and efficient intracellular reduction stimulus‐responsive drug‐delivery vehicles.
Annual report to the nation on the status of cancer, part II: Progress toward Healthy People 2020 objectives for 4 common cancers
Authors: Henley S. Jane , Thomas Cheryll C. , Lewis Denise Riedel , Ward Elizabeth M. , Islami Farhad , Wu Manxia , Weir Hannah K. , Scott Susan , Sherman Recinda L. , Ma Jiemin , Kohler Betsy A. , Cronin Kathleen , Jemal Ahmedin , Benard Vicki B. , Richardson Lisa C. 
Published: March 2020

BackgroundThe Centers for Disease Control and Prevention, the American Cancer Society, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate to provide annual updates on cancer occurrence and trends in the United States and to address a special topic of interest. Part I of this report focuses on national cancer statistics, and part 2 characterizes progress in achieving select Healthy People 2020 cancer objectives.MethodsFor this report, the authors selected objectives—including death rates, cancer screening, and major risk factors—related to 4 common cancers (lung, colorectal, female breast, and prostate). Baseline values, recent values, and the percentage change from baseline to recent values were examined overall and by select sociodemographic characteristics. Data from national surveillance systems were obtained from the Healthy People 2020 website.ResultsTargets for death rates were met overall and in most sociodemographic groups, but not among males, blacks, or individuals in rural areas, although these groups did experience larger decreases in rates compared with other groups. During 2007 through 2017, cancer death rates decreased 15% overall, ranging from −4% (rural) to −22% (metropolitan). Targets for breast and colorectal cancer screening were not yet met overall or in any sociodemographic groups except those with the highest educational attainment, whereas lung cancer screening was generally low (<10%). Targets were not yet met overall for cigarette smoking, recent smoking cessation, excessive alcohol use, or obesity but were met for secondhand smoke exposure and physical activity. Some sociodemographic groups did not meet targets or had less improvement than others toward reaching objectives.ConclusionsMonitoring trends in cancer risk factors, screening test use, and mortality can help assess the progress made toward decreasing the cancer burden in the United States. Although many interventions to reduce cancer risk factors and promote healthy behaviors are proven to work, they may not be equitably applied or work well in every community. Implementing cancer prevention and control interventions that are sustainable, focused, and culturally appropriate may boost success in communities with the greatest need, ensuring that all Americans can access a path to long, healthy, cancer‐free lives.