bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coumarin derivatives: Synthesis and cation binding properties
Authors: Naouali Olfa , Frija Rached , Elgabsi Wissal , Hamdi Naceur , Baklouti Lassaad 
Published: April 2020

Coumarin derivatives were easily prepared starting from 7-hydroxy 4-methyl-2H-chromen-2-oneÂ with 40% formaldehyde and suitable secondary amines in 95% ethanol in rather good yield. The structures of allÂ compounds were confirmed via spectroscopic techniques IR, 1H NMR, 13C NMR, mass spectra and elemental analysis. The complexing properties of the coumarin derivatives toward alkali metal, alkaline earth metal, someÂ transition metals and some heavy metal cations have been investigated in methanol by means ofÂ UV spectrophotometry absorption and conductivity methods. Thus, the stoichiometry of the complexes formedÂ and their stability constants were determined.
Feasibility of multimodal multiphoton microscopy to facilitate surgical margin assessment in pancreatic cancer: erratum
Authors: Pham Thu , Banerjee Bhaskar , Cromey Benjamin , Mehravar Soroush , Skovan Bethany , Chen Hao , Kieu Khanh 
Published: April 2020

After publication of our original paper Appl. Opt.
59, G1 (2020)APOPAI0003-693510.1364/AO.391315, it came
to the authors’ attention that there were missing labels on Fig. 5.
The labels are important for our readers to understand the figure.
Psychological Burden of Hepatic Encephalopathy on Patients and Caregivers
Authors: Fabrellas Núria , Moreira Rebeca , Carol Marta , Cervera Marta , de Prada Gloria , Perez Martina , Vazquez Elena , Sola Montse , Sancho Raul , Juanola Adrià , Pose Elisa , Solé Cristina , Graupera Isabel , Solà Elsa , Kamath Patrick S. , Ginès Pere 
Published: April 2020

OBJECTIVES:
Hepatic encephalopathy (HE) is common in advanced cirrhosis and is characterized by marked neuropsychiatric abnormalities. However, despite its severity and effects on brain function, the impact of HE on psychological status of patients has not been adequately assessed. The aim of this study was to evaluate the effect of HE on psychological status of patients and their informal caregivers.

METHODS:
Fifteen patients with cirrhosis and episodic or persistent HE and their corresponding informal caregivers were included. Semistructured interviews were performed in patients and caregivers. Quality of life (QoL) was assessed by the short-form 36 in both patients and caregivers, and the Zarit burden score was measured in caregivers. The analysis of interviews was performed using qualitative methodology.

RESULTS:
HE causes a major psychological impact on patients with HE. The first episode of HE caused a very significant impact that was reported with deep feelings, mainly of fear, anger, misery, anxiety, and sorrow, which persisted with time. Symptoms causing more psychological impact on patients were impaired ability to walk and speak. All effects were associated with a marked impairment in QoL. The psychological impact was also marked in caregivers who had a major burden, as assessed by the Zarit score. Moreover, QoL, particularly the mental component score, was markedly impaired in caregivers in intensity similar to that of patients.

DISCUSSION:
HE has a profound psychological impact on patients and their informal caregivers, associated with a marked negative influence on QoL. The psychological effects of HE on patients and caregivers should be evaluated and treated.
Shaykh Mutawalli al-Sha'rawi's Views About Tafsir and I'jaz al-Qur'an: (Descriptive-Analysis Study)
Authors: Kusroni Kusroni 
Published: April 2020

This paper discusses the views of Shaikh Mutawalli al-Sha'rawi about the interpretation and i'jaz al-Qur'an contained in his book titled al-Tafsir al-Sha'rawi or Khawa> tir al-Sha'rawi. al-Sha'rawi is known as one of the leading modern scholars giving great attention and defense of the Qur'an. His attention to the Qur'an evidently appears in his commentary, a collection of lectures, sermons and studies in various pulpits and scientific forums. The method of delivering ideas taken by al-Sha'rawi in this work is by asking a number of questions about the existence of the i'jaz al-Qur'an, then he gives simple but argumentative answers, both aqliyah and naqliyah. Therefore, from here we know how his views related to interpretation and i'jaz al-Qur'an. Al-Sha'rawi argues that, the prophet of Muhammad is the person who is most worthy of interpreting the Qur'an, because to him al-Qur'an was revealed. So he knows and practices it, and from it the mu‘jizat of the Qur'an was manifested. According to him, the mu‘jizat of the Qur'an is evolutionary and evolves with the times and with the progress of modern science and civilization.[يتكلم هذا الموضوع عن موقف الشيخ متولي الشعراوي حول القرآن وما يتعلق به من تفسير وإعجاز وغيره المكتوب فى كتابه المسمى بـ "التفسير الشعراوي" أوبـ "خواطر الشعراوي".ومما لا شك فيه أن هذا الشيخ الكبير يُعَدّ من جهابذة العلماء المعاصرين الذين يهتمون بالدفاع عن القرآن دفاعا قوياً. ويظهر هذا الدفاع عندما نلاحظ هذا الكتاب الذي هو منتخبات ومقتطفات مما ألقاه الشيخ الشعراوي خلال محاضرته وخُطبه ودروسه في البرامج والمناسبات المختلفة. والجدير بالذكر أنّ المنهج الذي سلك به الشيخ هو الإتيان بالتسائلات حول القرآن ما يدل على الترييب والتشكيك فى الجانب الإعجازي للقرآن الكريم, ثم يأتي هو بالأجوبة الصارحة مع الحجج القاطعة. رغم أنه أتى بالحجة النقليةالكثيرة لكنه في نفس الوقت أورد الأدلة العقلية. ومن ثم يظهرلنا أفكاره العلمية حول القرآن الكريم تفسيرا وإعجازا. ويرى الشيخ أن أولى الناس بالتفسير هوالرسول ﷺ لأنه عليه نزل وبه علم وعمل وله ظهرت معجزاته. وأن الإعجاز القرآني عنده يتطوّر مع تطوّر الأزمان والعلوم العصرية والثقافة والحضارة.]
Effect of Flippeed Classroom Models and Creative Thinking of Science Literation Students
Authors: Susanti Wiwi , Supena Asep , Cahyana Ucu 
Published: April 2020

The flipped classroom model, which is often heard in recent years, is known as a new pedagogical approach in which traditional instruction is reversed. The study aims to determine the effect of the flipped classroom model and creative thinking on the scientific literacy of grade VI students of SDN Guntur 01, South Jakarta. This research uses a 2x2 factorial design. The research sample was divided into two treatment groups, namely the experimental class and the control class. The experimental class was given treatment by carrying out the learning model of the flipped classroom , while the control class was given treatment by carrying out the expository model learning. The results showed: (1) there was a difference in scientific literacy between the experimental class and the control class, with scientific literacy higher than the control class. (2) there is a difference in scientific literacy between groups of students with high levels of creative thinking in the experimental class [A 1 B 1 ] and the control class [A 2 B 1 ]. (3) there is a difference in scientific literacy between groups of students with low creative thinking levels in the experimental class [A 1 B 2 ] and the control class [A 2 B 2 ]. (4) there is an effect of interaction between learning models and creative thinking on scientific literacy. Purpose of the flipped classroom model is to use face to face time more effectively in the learning process. There are many definitions related to flipped classroom is a student-centred learning method consisting of two parts with interactive learning activities during lesson and individual teaching based on computer out of lesson.
Assessing and Addressing the Need for Cancer Patient Education in a Resource-Limited Setting in Haiti
Authors: Schleimer Lauren E. , Desameau Peter-Gens , Damuse Ruth , Olsen Maia , Manzo Veronica , Cardenas Carlos , Mehrtash Hedieh , Krakauer Eric L. , Masamba Leo , Wang Catharine , Bhatt Ami S. , Shulman Lawrence N. , Huang Franklin W. 
Published: April 2020

Abstract

Purpose
Misinformation and lack of information about cancer and its treatment pose significant challenges to delivering cancer care in resource-limited settings and may undermine patient engagement in care. We aimed to investigate patients’ knowledge and attitudes toward cancer and its treatment and to adapt, implement, and evaluate a low-literacy cancer patient education booklet at the Hôpital Universitaire de Mirebalais (HUM) in rural Haiti.

Materials and Methods
A low-literacy cancer patient education booklet was adapted into Haitian Creole in collaboration with clinicians at HUM. Patients were recruited for structured interviews (n = 20) and two focus groups (n = 13) designed to explore patients’ attitudes toward cancer and its treatment and to assess whether the booklet increased patients’ knowledge via an investigator-designed knowledge test.

Results
Participants reported a subjective lack of knowledge about cancer and its treatments and described views of cancer as deadly or incurable. Patients of varying education levels valued receiving written materials that set expectations about cancer treatment and expressed a desire to share the booklet with caregivers and others in their community. Participants across all levels of education significantly increased their performance on a knowledge test after counseling using the booklet (p &lt; .001).

Conclusion
We found that an educational booklet about cancer developed in collaboration with local providers was well received by patients with variable literacy levels and improved their knowledge of cancer and its treatment in a resource-limited setting. Such educational materials have the potential to serve as tools to engage patients with cancer and their families in care.

Implications for Practice
Misinformation and lack of information pose significant challenges to delivering cancer care in resource-limited settings; however, there are often no culturally and literacy appropriate tools available to aid in patient education. This article shows that written educational materials are well received by patients of variable literacy levels and can be effective tools for increasing patients’ knowledge of cancer and its treatment in a limited-resource setting. Furthermore, the authors have made their educational booklet, Cancer and You, freely available online and welcome the opportunity to connect with readers of The Oncologist interested in implementing this educational booklet in clinical care.
Multiple Myeloma Incidence and Mortality Around the Globe; Interrelations Between Health Access and Quality, Economic Resources, and Patient Empowerment
Authors: Ludwig Heinz , Novis Durie Susie , Meckl Angela , Hinke Axel , Durie Brian 
Published: April 2020

Abstract

Background
The interrelation between the worldwide incidence, mortality, and survival of patients with multiple myeloma (MM) and relevant factors such as Health Care Access and Quality (HAQ) index, gross domestic product (GDP), health care expenditures, access to cancer drugs, and patient empowerment has not been addressed before.

Material and Methods
Epidemiologic data were obtained from the International Agency for Research on Cancer. The mortality-to-incidence ratio (expressed as 1-MIR) was used as proxy for 5-year survival. Information on health expenditure was obtained from Bloomberg Health-Care Efficacy ranking, the HAQ Index was used as a measure of available health care. For patient empowerment, visits to the Web site of the International Myeloma Foundation were used as proxy. Data on GDP and population per country were assessed from the International Monetary Fund and the United Nations Population Division, respectively. Possible associations were analyzed using Spearman's rank-order correlation.

Results
The worldwide incidence of MM is currently 160,000, and mortality is 106,000. Age-standardized myeloma incidence varies between 0.54 and 5.3 per 100,000 and correlates with 1-MIR, patient empowerment, HAQ Index, and access to cancer drugs. The 1-MIR varies between 9% and 64% and is closely related to myeloma incidence, HAQ Index, patient empowerment, access to cancer drugs, and health care expenditures.

Conclusion
The global incidence and outcome of MM shows significant disparities, indicating under-recognition and suboptimal treatment in many parts of the globe. Results also highlight the importance of economic resources, access to and quality of health care, and patient education for improving diagnosis and survival of patients with MM.

Implications for Practice
Multiple myeloma accounts for 10% of all hematological malignancies and has moved to the forefront of clinical interest because of the significant advances in medical treatment. Diagnosis depends on laboratory tests, imaging, and professional expertise, particularly in patients without a significant M-component. The present data show a substantial worldwide variation in incidence and mortality, that is mainly due (apart from variations due to ethnicity and lifestyle) to disparities in access to and quality of health care, a parameter strongly related to the economic development of individual countries. Improvement of quality of care and, consequently, in outcome is associated with patient empowerment.
El ve El bilek yumuşak doku tümörlü hastalarda eksizyonel cerrahi kısa dönem sonuçları
Authors: ACAR Erdinç , GÜLTEKİN Alper 
Published: April 2020

Amaç:
El ve el bilekte yumuşak doku kitlesi ile kliniğimize başvurup eksizyonel
cerrahi tedavi uyguladığımız hastaların kısa dönem sonuçları değerlendirildi.

Gereç ve Yöntem:
Çalışmaya, Aralık 2017 ile Mayıs 2019 tarihleri arasında eksizyonel cerrahi
tedavi uygulanan 34 hasta (25 bayan, 9 erkek) dahil edildi. Bu hastaların
ameliyat sonrası patoloji sonuçlarında; 20 hastada ganglion kisti, 6 hastada
epidermal inklüzyon kisti, 4 hastada tendon kılıfı dev hücreli tümör, 2 hastada
lipom, 1 hastada hemanjiom ve 1 hastada düşük dereceli (low grade) liposarkom şeklinde sonuç alındı. Bu hastalarda yineleme
oranı ve mennuniyet oranları değerlendirildi. Cerrahi sonrası yara yeri
enfeksiyonu ve nörovasküler yaralanma gibi komplikasyonlar değerlendirilmiştir.

Bulgular:
Hastaların yaş ortalaması 42,6 (29-57). Hastaların 25’i (%73,6) bayan, 9’u
(%26,4) erkek idi. Hastalar ortalama 13 ay (10-18) takip edildi. Hastalarda
yineleme izlenmedi. Hastaların tamamı, cerrahi tedaviden memnun kaldıklarını
belirtti.

Sonuç:
El ve el bilek yumuşak doku tümörü olan hastalarda uygulanan düzgün ve başarılı
eksizyonel cerrahi tedavi; nüks ve komplikasyon gelişmemesi açısından yararlı bir
yöntem olarak karşımıza çıkmaktadır.Introduction:
In this study,
we report our short-term results of excisional surgery in patients with soft
tissue tumors of the hand and wrist.Methods:
A total of 34
patients who were admitted with a soft tissue lesion of the hand and wrist and
underwent excisional surgery in our clinic between December 2017 and May 2019
were included. Pathological examination results were reported as a ganglion cyst
in 20, an epidermal inclusion cyst in six, a giant cell tumor of tendon sheath
in four, a lipoma in two, a hemangioma in one, and a low-grade liposarcoma in
one patient. Recurrence rate and patient satisfaction were evaluated.
Postoperative complications such as wound infections and neurovascular events
were recorded.Results:
Of the patients,
25 (73.6%) were females and 9 (26.4%) were males. The mean age was 42.6 (range,
29 to 57) years. The mean follow-up was 13 (range, 10 to 18) months. No recurrence
was seen in any of the patients. The rate of patient satisfaction was 100% in
all patients.Discussion
and Conclusion: Our study
results suggest that a well-planned excisional surgery is an effective and
feasible method for the treatment of soft tissue tumors of the hand and wrist
and has no potential risk for recurrence or postoperative complications.
A five-year study of Influenza A (H1N1) pandemic 09 from Central India
Authors: Shendre Pooja , Raut Sharmila , Khadse Ravindra 
Published: April 2020

Influenza virus is a typical human pathogen causing serious respiratory infection. While declaring the last pandemic to be over in August 2010, World Health Organisation (WHO) conveyed that Pandemic Influenza A (HINI) virus would circulate as Seasonal Influenza virus for years to come. This study was undertaken to observe trends of Influenza A (H1N1) pandemic 09 over last five years in Vidarbha region of Maharashtra. Throat/nasal/nasopharyngeal swabs/aspirates from clinically suspected cases of influenza like illness in category C received in the Viral Research and Diagnostic Lab (VRDL), Indira Gandhi Govt Medical College (IGGMC), Nagpur from October 2015 to September 2019 were included in the study. The samples were tested by reverse transcriptase real time polymerase chain reaction (RT-PCR). Clinical and epidemiological parameters were also noted. Inﬂuenza A(H1N1)pandemic 09 positivity ranged from 03% to 21% in last five years. Males and females were almost equally affected except in 2019. Maximum positive cases were seen in age group of 41-60 years in 2015 (24%), 0-10 years in 2017(24%), 21-40 years in 2018 (9%) and 11-20 years (26%) in 2019 . Dual peaks of infection were seen in 2017, 2018 and 2019. Bhandara, Gondia and Akola districts had highest positivity .Inﬂuenza A(H1N1)pandemic 09 is showing shift towards younger age groups and females slightly, both of which needs attention. Waning and waxing trend in last five years indicate unpredictable and changing epidemiology of the virus which should be studied further in details with respect to time, place, person and molecular characterisation of the virus.
Study of prevalence Rifampicin and/ or Isoniazid drug resistance among newly diagnosed cases of sputum smear positive pulmonary tuberculosis at tertiary care centre
Authors: Dilip Muley Sushant , Meshram Sushant , Yadav Ravi , Naeem Tauseef , Gandhare Avinash 
Published: April 2020

Worldwide tuberculosis is most common infectious cause of death. India bears one-fourth of the global tuberculosis burden. Despite all national & international efforts to control & eliminate tuberculosis, more than 10 million active tuberculosis cases occur each year. The problem of tuberculosis has been further compounded by the emergence of multi drug resistant (MDR) and extensively drug resistant(XDR) tuberculosis. Previously treated tuberculosis is most important risk factor for drug resistant TB but treatment naïve patients are also at risk due to transmission of drug resistant strain or spontaneous mutation.Study was conducted in Department Of Respiratory Medicine, GMC Nagpur between May 2017 to October 2018.It was prospective observational study. All sputum smear positive cases were subjected to mycobacterial culture and LPA testing in IRL.Total 250 patients whose sputum smear was positive for acid fast bacilli were included in study. Maximum patients were in age group of 18-30 years of age with mean age 36.43+/-14.05.Out of 250 patient 188 were males and 62 were females. Isoniazid monoresistance was found in 6 patients and isoniazid with rifampicin resistance was found in 9 patients. We did not find any case of rifampicin monoresistance in our study.Prevalence of isoniazid monoresistance was 2.4 % in our study while prevalence of isoniazid and rifampicin resistance (MDR TB) was 3.6%. Thus prevalence of drug resistant TB is low amongst newly diagnosed sputum smear positive cases. This shows success of tuberculosis control programme.
A study of aerobic bacteriological profile of surgical site infections in a tertiary care hospital
Authors: Kumar S Mahesh , B.A Mythri , B Patil Asha , Pramod Gana , Uppar Akshata 
Published: April 2020

Surgical Site Infection (SSI) is the leading cause of all Healthcare Associated Infections in developing countries. SSIs are a frequent cause of morbidity and mortality among inpatients of hospitals. For proper management of the patients it is very essential to know which pathogen has caused the infection and also its antibiotic susceptibility.1. To determine the aerobic bacteriological profile, 2. To know the antibiotic susceptibility patterns of the bacterial isolates. This retrospective study was carried out on 320 culture positive swabs, tissue & discharge samples received over a one year period from January 2019 to December 2019 in the department of Microbiology from Surgery, Orthopaedics & Obstetrics and Gynaecology (OBG) departments. Data analysis was done on the microbiological profile of the aerobic isolates and its antibiotic susceptibility pattern. Among the 320 samples monomicrobial growth was seen in 316 (98.75%) samples whereas polymicrobial growth was seen in 04 samples (1.25%). Out of the 324 isolates Gram negative bacilli constituted 239(73.76%) and Gram positive cocci constituted 26.24%. The predominant isolate in the study was 101(31.17%) followed by 68(20.98%).The other major isolates were Citrobacter spp. 48(14.81%), . 41(12.65%), 24(7.41%), 17(5.25%) and Pseudomonas aeruginosa 14(4.31%). This study shows that and are the commonest organisms associated with the surgical site infection. Simple measures like appropriate hand hygiene can go a long way in bringing down the rate of SSI as well as slowing down the further spread of the resistant hospital strains.
Daptomycin susceptibility in enterococci isolated from urinary samples in a tertiary care hospital
Authors: M.S.S Pradeep , Yarava Saritha , Rao K Vishnuvardhan 
Published: April 2020

are gram positive cocci encountered in various human infections.The most striking feature of is their relative and absolute resistance to variety of antibiotics.Vancomycin resistant (VRE) were first described in late 1980 and the incidence of nosocomial infections by VRE being 11.9% in Asia Pacific and 35.5% in U.S. Daptomycin is a lipopeptide antibiotic with bactericidal activity . To study the daptomycin susceptibility in isolated in urinary samples. A total of 76 strains of were isolated during the study period.25 (33%) were identified as and 51 (67%) as Most of the Enterococcal isolates (82.8%) were resistant to Norfloxacin followed by 71% being resistant to tetracycline and 76% of isolates were sensitive to nitrofurantoin. Most of the isolates were multidrug resistant. Of the 76 isolated only 2(2.63%) were VRE and both the VRE strains isolated were . There was no resistance to linezolid including the VRE strains. All the isolates 76 (100%) were sensitive to daptomycin including the VRE strains. Our study mainly focused on susceptibility of enterococcal isolates in urinary samples to daptomycin which has bactericidal activity against gram positive organisms including multidrug resistant strains. This study shows growing concern for increasing antibiotic resistance in enterococcal isolates and treatment of these infections with daptomycin is invited as there are only few reports of daptomycin non susceptible (DNSE).