bluuebunny/crossref_metadata_2025_split huggingface dataset:
QTc Interval Prolongation and Life-Threatening Arrhythmias During Hospitalization in Patients With Coronavirus Disease 2019 (COVID-19): Results From a Multicenter Prospective Registry
Authors: Santoro Francesco , Monitillo Francesco , Raimondo Pasquale , Lopizzo Agostino , Brindicci Gaetano , Gilio Michele , Musaico Francesco , Mazzola Michele , Vestito Domenico , Benedetto Rossella Di , Abumayyaleh Mohammad , El-Battrawy Ibrahim , Santoro Carmen Rita , Di Martino Luigi Flavio Massimiliano , Akin Ibrahim , De Stefano Giulio , Fiorilli Rosario , Cannone Michele , Saracino Annalisa , Angarano Salvatore , Carbonara Sergio , Grasso Salvatore , Di Biase Luigi , Brunetti Natale Daniele 
Published: October 2020

Abstract

Background
Prolonged QTc intervals and life-threatening arrhythmias (LTA) are potential drug-induced complications previously reported with antimalarials, antivirals, and antibiotics. Our objective was to evaluate the prevalence and predictors of QTc interval prolongation and incidences of LTA during hospitalization for coronavirus disease 2019 (COVID-19) among patients with normal admission QTc.

Methods
We enrolled 110 consecutive patients in a multicenter international registry. A 12-lead electrocardiograph was performed at admission, after 7, and at 14 days; QTc values were analyzed.

Results
After 7 days, 15 (14%) patients developed a prolonged QTc (pQTc; mean QTc increase 66 ± 20 msec; +16%; P &lt; .001); these patients were older and had higher basal heart rates, higher rates of paroxysmal atrial fibrillation, and lower platelet counts. The QTc increase was inversely proportional to the baseline QTc level and leukocyte count and directly proportional to the basal heart rate (P &lt; .01).
We conducted a multivariate stepwise analysis including age, male gender, paroxysmal atrial fibrillation, basal QTc values, basal heart rate, and dual antiviral therapy; age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.00–1.13; P &lt; .05), basal heart rate (OR, 1.07; 95% CI, 1.02–1.13; P &lt; .01), and dual antiviral therapy (OR, 12.46; 95% CI, 2.09–74.20; P &lt; .1) were independent predictors of QT prolongation.
The incidence rate of LTA during hospitalization was 3.6%. There was 1 patient who experienced cardiac arrest and 3 with nonsustained ventricular tachycardia. LTAs were recorded after a median of 9 days from hospitalization and were associated with 50% of the mortality rate.

Conclusions
After 7 days of hospitalization, 14% of patients with COVID-19 developed pQTc; age, basal heart rate, and dual antiviral therapy were found to be independent predictors of pQTc. Life-threatening arrhythmias have an incidence rate of 3.6%, and were associated with a poor outcome.
The risk of cardiac events in patients receiving immune checkpoint inhibitors: a nationwide Danish study
Authors: D’Souza Maria , Nielsen Dorte , Svane Inge Marie , Iversen Kasper , Rasmussen Peter Vibe , Madelaire Christian , Fosbøl Emil , Køber Lars , Gustafsson Finn , Andersson Charlotte , Gislason Gunnar , Torp-Pedersen Christian , Schou Morten 
Published: October 2020

Abstract

Aims
The study aimed to estimate the risk of cardiac events in immune checkpoint inhibitor (ICI)-treated patients with lung cancer or malignant melanoma.

Methods and results
The study included consecutive patients with lung cancer or malignant melanoma in 2011–17 nationwide in Denmark. The main composite outcome was cardiac events (arrhythmia, peri- or myocarditis, heart failure) or cardiovascular death. Absolute risks were estimated and the association of ICI and cardiac events was analysed in multivariable Cox models. We included 25 573 patients with lung cancer. Of these, 743 were treated with programmed cell death-1 inhibitor (PD1i) and their 1-year absolute risk of cardiac events was 9.7% [95% confidence interval (CI) 6.8–12.5]. Of the 13 568 patients with malignant melanoma, 145 had PD1i and 212 had cytotoxic T-lymphocyte-associated protein-4 inhibitor (CTLA-4i) treatment. Their 1-year risks were 6.6% (1.8–11.3) and 7.5% (3.7–11.3). The hazard rates of cardiac events were higher in patients with vs. without ICI treatment. Within 6 months from 1st ICI administration, the hazard ratios were 2.14 (95% CI 1.50–3.05) in patients with lung cancer and 4.30 (1.38–13.42) and 4.93 (2.45–9.94) in patients with malignant melanoma with PD1i and CTLA-4i, respectively. After 6 months, HRs were 2.26 (1.27–4.02) for patients with lung cancer and 3.48 (1.91–6.35) for patients with malignant melanoma and CTLA-4i.

Conclusions
Among patients with lung cancer and malignant melanoma, ICI treated had increased rates of cardiac events. The absolute risks were higher in these data compared with previous pharmacovigilance studies (e.g. 1.8% peri-/myocarditis 1-year risk).
Procedural myocardial injury, infarction and mortality in patients undergoing elective PCI: a pooled analysis of patient-level data
Authors: Silvain Johanne , Zeitouni Michel , Paradies Valeria , Zheng Huili L , Ndrepepa Gjin , Cavallini Claudio , Feldman Dimitri N , Sharma Samin K , Mehilli Julinda , Gili Sebastiano , Barbato Emanuele , Tarantini Giuseppe , Ooi Sze Y , von Birgelen Clemens , Jaffe Allan S , Thygesen Kristian , Montalescot Gilles , Bulluck Heerajnarain , Hausenloy Derek J 
Published: October 2020

AbstractAimsThe prognostic importance of cardiac procedural myocardial injury and myocardial infarction (MI) in chronic coronary syndrome (CCS) patients undergoing elective percutaneous coronary intervention (PCI) is still debated.Methods and resultsWe analysed individual data of 9081 patients undergoing elective PCI with normal pre-PCI baseline cardiac troponin (cTn) levels. Multivariate models evaluated the association between post-PCI elevations in cTn and 1-year mortality, while an interval analysis evaluated the impact of the size of the myocardial injury on mortality. Our analysis was performed in the overall population and also according to the type of cTn used [52.0% had high-sensitivity cTn (hs-cTn)]. Procedural myocardial injury, as defined by the Fourth Universal Definition of MI (UDMI) [post-PCI cTn elevation ≥1 × 99th percentile upper reference limit (URL)], occurred in 52.8% of patients and was not associated with 1-year mortality [adj odds ratio (OR), 1.35, 95% confidence interval (CI) (0.84–1.77), P = 0.21]. The association between post-PCI cTn elevation and 1-year mortality was significant starting ≥3 × 99th percentile URL. Major myocardial injury defined by post-PCI ≥5 × 99th percentile URL occurred in 18.2% of patients and was associated with a two-fold increase in the adjusted odds of 1-year mortality [2.29, 95% CI (1.32–3.97), P = 0.004]. In the subset of patients for whom periprocedural evidence of ischaemia was collected (n = 2316), Type 4a MI defined by the Fourth UDMI occurred in 12.7% of patients and was strongly associated with 1-year mortality [adj OR 3.21, 95% CI (1.42–7.27), P = 0.005]. We also present our results according to the type of troponin used (hs-cTn or conventional troponin).ConclusionOur analysis has demonstrated that in CCS patients with normal baseline cTn levels, the post-PCI cTn elevation of ≥5 × 99th percentile URL used to define Type 4a MI is associated with 1-year mortality and could be used to detect ‘major’ procedural myocardial injury in the absence of procedural complications or evidence of new myocardial ischaemia.
The Effects of Graded Levels of Calorie Restriction: XVI. Metabolomic Changes in the Cerebellum Indicate Activation of Hypothalamocerebellar Connections Driven by Hunger Responses
Authors: Green Cara L , Mitchell Sharon E , Derous Davina , García-Flores Libia A , Wang Yingchun , Chen Luonan , Han Jing-Dong J , Promislow Daniel E L , Lusseau David , Douglas Alex , Speakman John R 
Published: October 2020

AbstractCalorie restriction (CR) remains the most robust intervention to extend life span and improve healthspan. Though the cerebellum is more commonly associated with motor control, it has strong links with the hypothalamus and is thought to be associated with nutritional regulation and adiposity. Using a global mass spectrometry-based metabolomics approach, we identified 756 metabolites that were significantly differentially expressed in the cerebellar region of the brain of C57BL/6J mice, fed graded levels of CR (10, 20, 30, and 40 CR) compared to mice fed ad libitum for 12 hours a day. Pathway enrichment indicated changes in the pathways of adenosine and guanine (which are precursors of DNA production), aromatic amino acids (tyrosine, phenylalanine, and tryptophan) and the sulfur-containing amino acid methionine. We also saw increases in the tricarboxylic acid cycle (TCA) cycle, electron donor, and dopamine and histamine pathways. In particular, changes in l-histidine and homocarnosine correlated positively with the level of CR and food anticipatory activity and negatively with insulin and body temperature. Several metabolic and pathway changes acted against changes seen in age-associated neurodegenerative disorders, including increases in the TCA cycle and reduced l-proline. Carnitine metabolites contributed to discrimination between CR groups, which corroborates previous work in the liver and plasma. These results indicate the conservation of certain aspects of metabolism across tissues with CR. Moreover, this is the first study to indicate CR alters the cerebellar metabolome, and does so in a graded fashion, after only a short period of restriction.
Construction of fault geometry by finite-fault inversion of teleseismic data
Authors: Shimizu Kousuke , Yagi Yuji , Okuwaki Ryo , Fukahata Yukitoshi 
Published: October 2020

SUMMARYConventional seismic source inversion estimates the earthquake rupture process on an assumed fault plane that is determined a priori. It has been a difficult challenge to obtain the fault geometry together with the rupture process by seismic source inversion because of the nonlinearity of the inversion technique. In this study, we propose an inversion method to estimate the fault geometry and the rupture process of an earthquake from teleseismic P waveform data, through an elaboration of our previously published finite-fault inversion analysis (Shimizu et al. 2020). That method differs from conventional methods by representing slip on a fault plane with five basis double-couple components, expressed by potency density tensors, instead of two double-couple components compatible with the fault direction. Because the slip direction obtained from the potency density tensors should be compatible with the fault direction, we can obtain the fault geometry consistent with the rupture process. In practice we rely on an iterative process, first assuming a flat fault plane and then updating the fault geometry by using the information included in the obtained potency density tensors. In constructing a non-planar model-fault surface, we assume for simplicity that the fault direction changes only in either the strike or the dip direction. After checking the validity of the proposed method through synthetic tests, we applied it to the MW 7.7 2013 Balochistan, Pakistan, and MW 7.9 2015 Gorkha, Nepal, earthquakes, which occurred along geometrically complex fault systems. The modelled fault for the Balochistan earthquake is a curved strike-slip fault convex to the south-east, which is consistent with the observed surface ruptures. The modelled fault for the Gorkha earthquake is a reverse fault with a ramp-flat-ramp structure, which is also consistent with the fault geometry derived from geodetic and geological data. These results exhibit that the proposed method works well for constraining fault geometry of an earthquake.
The not-so-great transformation
Authors: Ard B J 
Published: October 2020

Abstract
Many have attributed the excesses of private power in the digital age to the internet’s “lawlessness.” Julie Cohen’s Between Truth and Power explains why this is a dangerous misconception. The law has not sat idle during the rise of informational capitalism; it has undergone extensive transformation and now facilitates corporate surveillance and manipulation on a global scale. Meanwhile, legal institutions have taken a turn towards managerialism and away from democratic accountability. Recognizing these transformations and the ideologies that motivate them is critical to grappling with the legal challenges of the digital era.
Fast wavelet decomposition of linear operators through product-convolution expansions
Authors: Escande Paul , Weiss Pierre 
Published: October 2020

Abstract
Wavelet decompositions of integral operators have proven their efficiency in reducing computing times for many problems, ranging from the simulation of waves or fluids to the resolution of inverse problems in imaging. Unfortunately, computing the decomposition is itself a hard problem which is oftentimes out of reach for large-scale problems. The objective of this work is to design fast decomposition algorithms based on another representation called product-convolution expansion. This decomposition can be evaluated efficiently, assuming that a few impulse responses of the operator are available, but it is usually less efficient than the wavelet decomposition when incorporated in iterative methods. The proposed decomposition algorithms, run in quasi-linear time and we provide some numerical experiments to assess its performance for an imaging problem involving space-varying blurs.
BRAF V600E as an accurate marker to complement fine needle aspiration (FNA) cytology in the guidance of thyroid surgery in the Chinese population: evidence from over 1000 consecutive FNAs with follow-up
Authors: Zhao Qunzi , Wang Yong , Ye Qin , Wang Ping , Rao Jianyu 
Published: October 2020

Abstract

Background
Currently, several commercial molecular tests have been developed for reclassifying thyroid nodules with indeterminate fine needle aspiration cytology. These tests are quite expensive and not available in China. Previous studies demonstrated a very high prevalence of the BRAF V600E mutation in Asian people. A high incidence may result in a robust sensitivity. We conducted this study to determine the prevalence of BRAF V600E mutation and its ability to reclassify cytologically indeterminate thyroid nodules in the Chinese population.

Methods
Between January 2016 and October 2018, consecutive patients who underwent a fine needle aspiration procedure and agreed to provide materials for molecular analysis in our hospital were recruited in this study. All were followed up until they had a thyroidectomy and a final pathological diagnosis or until January 2019 (those did not have surgery).

Results
A total of 1960 patients were included in this study. Until January 2019, 1240 patients underwent surgery. Using histopathological diagnosis as a gold standard, the overall sensitivity and specificity of the BRAF V600E mutational analysis for the discrimination of benign nodules from cancer in thyroid fine needle aspiration samples were 83.3% (81.0–85.3%) and 96.0% (77.7–99.8%), respectively, with an area under the ROC curve of 0.90 (95% CI 0.85–0.95, P &lt; 0.001). Among cases with indeterminate cytology, BRAF-positive cases were showing malignancy in the final pathology, and BRAF-negative cases were showing safer to be followed up.

Conclusion
The BRAF V600E mutation is highly prevalent in the Chinese population and can accurately complement cytopathology in the guidance of thyroid surgery.
Mini-abstract: The BRAF V600E mutation has both high specificity and sensitivity to predict thyroid malignancy in the Chinese population. It can accurately complement cytopathology in the guidance of thyroid surgery.
Management of an inflammatory abdominal aortic aneurysm causing ureteric obstruction: a case report
Authors: Kim Yewon , Ghaly Paul , Iliopoulos Jim , Leslie Gregory J , Ahmad Mehtab 
Published: October 2020

Abstract
Inflammatory abdominal aortic aneurysms (IAAAs) are rare large-vessel pathology, with potentially life-threatening complications including obstructive uropathy secondary to retroperitoneal fibrosis. Comprising a small proportion of all AAA, their pathogenesis remains unknown, with the hypothesis of infective and immunological aetiologies circulating in current literature. Management principles of IAAAs aim at prevention of aortic rupture and include open-surgical or endovascular therapies. Due to their involvement of other structures, additional considerations are needed when approaching their management for optimal patient outcomes.
We present the case of a 53-year-old otherwise healthy male with a large IAAA complicated by adjacent ureteric obstruction, successfully treated with ureteric stenting and delayed endovascular aortic aneurysm repair.
Postoperative Brown-Séquard syndrome: case report and review of the literature
Authors: Belo Diogo , Teixeira Joaquim Cruz , Lavrador José Pedro 
Published: October 2020

Abstract
Brown-Séquard syndrome (BSS) is a rare neurological condition caused by a hemi-lesion of the spinal cord and was first described in the 1800s. BSS is characterized by an ipsilateral absence of motor control and discriminatory/proprioceptive/vibratory sensation at and below the spinal level involved, associated with loss of contralateral temperature and pain sensation a couple of vertebral segments below the lesion. BSS is commonly associated with trauma, but can also be iatrogenic. The authors report a case of a patient who presented with neoplastic dorsal spinal cord compression and developed a BSS after surgical decompression and review of the literature of postoperative BSS cases.
Dissociative single and double photoionization of biphenyl (C12H10) by soft X-rays in planetary nebulae
Authors: Quitián-Lara Heidy M , Fantuzzi Felipe , Oliveira Ricardo R , Nascimento Marco A C , Wolff Wania , Boechat-Roberty Heloisa M 
Published: October 2020

ABSTRACT
Biphenyl (C12H10), or phenylbenzene, is an important building block of polycyclic aromatic hydrocarbons (PAHs), whose infrared spectral features are present in a variety of galactic and extragalactic sources. In this work, we use synchrotron radiation coupled with time-of-flight spectrometry to study the photoionization and photodissociation processes of biphenyl upon its interaction with soft X-ray photons at energies around the inner-shell C1s resonance. These results are compared with our previous studies with benzene (C6H6) and naphthalene (C10H8), and discussed in the context of four planetary nebulae featuring PAH infrared emission: BD+30○3639, NGC 7027, NGC 5315, and NGC 40. We show that the mass spectrum of biphenyl before the C1s resonance energy is dominated by single photoionization processes leading to C6H$_{5}^+$, C6H$_{4}\, ^{+\cdot}$, and C12H$_{10}\, ^{+\cdot}$, while after the resonance dissociation following multiple photoionization processes is dominant. The release of neutral C6H6 and C6H$_{5}\, ^\cdot$ species accounts for one of the most relevant dissociation processes starting from the doubly ionized biphenyl, indicating that heterolytic charge separation of the two phenyl rings is also achieved. By using quantum chemical calculations, we show that the biphenylic structure is a high-lying isomer of the singly and doubly ionized C12H10 species, whose minimum energy geometries are related to the acenaphthene molecule, composed of a C2-bridged naphthalene. Furthermore, we estimate the lifetime of biphenyl for 275 and 310 eV in photon-dominated regions of planetary nebulae. We discuss distinct processes that may enhance its lifetime and those of other small-sized PAHs in such astrophysical environments.
Polarimetric and radiative transfer modelling of HD 172555
Authors: Marshall Jonathan P , Cotton Daniel V , Scicluna Peter , Bailey Jeremy , Kedziora-Chudczer Lucyna , Bott Kimberly 
Published: October 2020

ABSTRACT
The debris disc around HD 172555 was recently imaged in near-infrared polarized scattered light by the Very Large Telescope’s Spectro-Polarimetric High-contrast Exoplanet REsearch instrument. Here we present optical aperture polarization measurements of HD 172555 by the HIgh Precision Polarimetric Instrument (HIPPI), and its successor HIPPI-2 on the Anglo-Australian Telescope. We seek to refine constraints on the disc’s constituent dust grains by combining our polarimetric measurements with available infrared and millimetre photometry to model the scattered light and continuum emission from the disc. We model the disc using the 3D radiative transfer code hyperion, assuming the orientation and extent of the disc as obtained from the SPHERE observation. After correction for the interstellar medium contribution, our multiwavelength HIPPI/-2 observations (both magnitude and orientation) are consistent with the recent SPHERE polarization measurement with a fractional polarization p = 62.4 ± 5.2 ppm at 722.3 nm, and a position angle θ = 67° ± 3°. The multiwavelength polarization can be adequately replicated by compact, spherical dust grains (i.e. from Mie theory) that are around 1.2 μm in size, assuming astronomical silicate composition, or 3.9 μm, assuming a composition derived from radiative transfer modelling of the disc. We were thus able to reproduce both the spatially resolved disc emission and polarization with a single grain composition model and size distribution.
Constraining delay time distribution of binary neutron star mergers from host galaxy properties
Authors: McCarthy Kevin S , Zheng Zheng , Ramirez-Ruiz Enrico 
Published: October 2020

ABSTRACT
Gravitational wave (GW) observatories are discovering binary neutron star mergers (BNSMs), and in at least one event we were able to track it down in multiple wavelengths of light, which allowed us to identify the host galaxy. Using a catalogue of local galaxies with inferred star formation histories and adopting a BNSM delay time distribution (DTD) model, we investigate the dependence of BNSM rate on an array of galaxy properties. Compared to the intrinsic property distribution of galaxies, that of BNSM host galaxies is skewed towards galaxies with redder colour, lower specific star formation rate, higher luminosity, and higher stellar mass, reflecting the tendency of higher BNSM rates in more massive galaxies. We introduce a formalism to efficiently make forecast on using host galaxy properties to constrain DTD models. We find comparable constraints from the dependence of BNSM occurrence distribution on galaxy colour, specific star formation rate, and stellar mass, all better than those from dependence on r-band luminosity. The tightest constraints come from using individual star formation histories of host galaxies, which reduces the uncertainties on DTD parameters by a factor of three or more. Substantially different DTD models can be differentiated with about 10 BNSM detections. To constrain DTD parameters at 10 per cent precision level requires about one hundred detections, achievable with GW observations on a decade time-scale.