bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Syndesmotic Augmentation Technique Using Nonabsorbable Suture-Tape for Acute and Chronic Syndesmotic Instability
Authors: Kwon John Y. , Stenquist Derek , Ye Michael , Williams Caroline , Giza Eric , Kadakia Anish R. , Kreulen Christopher 
Published: September 2020

Syndesmotic instability is a source of significant pain and disability. Both subtle instability and gross diastasis, whether acute or chronic, require stabilization and may benefit from reconstruction with ligamentous augmentation. The use of nonabsorbable suture-tape has emerged as a promising operative strategy, allowing surgeons to anatomically reconstruct the syndesmosis, in particular the anterior inferior tibiofibular ligament. The current work provides a detailed description of the technique and preliminary results of a patient cohort treated using nonabsorbable suture-tape for syndesmotic augmentation. Level of Evidence: Level V, expert opinion.
Awareness is the first step: What Ghanaian community pharmacists know about cancer
Authors: Mensah Kofi B. , Mensah Adwoa Bemah Boamah , Bangalee Varsha , Oosthuizen Frasia 
Published: September 2020

Objectives The goal of this study was to access the knowledge of a representative sample of community pharmacists in Ghana on general cancer, risk factors, signs and symptom and most common cancer counseling points known to community pharmacists. Methods A structured online questionnaire was administered to 435 registered community pharmacists in the sixteen regions of Ghana. Key findings: Mean score for knowledge of cancer among community pharmacists was 6.8 ± 1.61 points out of a maximum score of 15 points, categorizing the overall knowledge as inadequate. The overall assessment of pharmacists’ knowledge revealed that 74.6% of the participants had inadequate level of knowledge on cancer. Mean score for knowledge of cancer signs and symptoms among community pharmacists was 3.55 ± 1.85 out of a maximum score of 7 points, categorizing the overall knowledge as inadequate. The overall evaluation indicated that 79.03% of pharmacists had inadequate knowledge of signs and symptoms cancer. Mean score for knowledge of risk factors of cancer among community pharmacists was 5.25 ± 1.15 out of a maximum score of 12 points, categorizing the overall knowledge as inadequate. The overall assessment of the knowledge score indicates that 70.34% of pharmacists had inadequate knowledge about causes and risk factors of cancer. Almost all participating pharmacists (96.5%) recommended counselling point was avoidance of smoking as a cancer preventive measure. An inverse significant correlation was found between age and knowledge scores of signs and symptoms of cancer (r = −0.077, P = 0.038). There was a statistically significant relationship between pharmacists’ level of knowledge on cancer (whether adequate or inadequate) and the cancer items. Conclusions Knowledge of cancer, its signs and symptoms and its risk factors were inadequate among community pharmacists in Ghana. Efforts should be made to improve knowledge of community pharmacists on cancer through continuous education. Also, undergraduate pharmacy training in oncology should encourage to close knowledge gap of community pharmacists on cancer.
Evidence-based practice in social work: Who are the critics?
Authors: Finne Joakim 
Published: September 2020

Summary The aim of this study is to analyse attitudes towards and the utilisation of evidence-based practice among social workers in Norway. The data were collected in 2014–2015 from social workers in four Norwegian counties. The sample consists of 2060 social workers registered as members of the Norwegian Union of Social Educators and Social Workers. Findings The main findings in this study indicate that social workers in child welfare are generally less critical of evidence-based practice than those within social welfare. Higher education and knowledge about evidence-based practice are seen as predictors for less critical attitudes towards the concept. The findings further suggest that social workers who use manuals and standardised procedures are less critical of evidence-based practice. Applications Understanding social workers’ attitudes towards evidence-based practice is important in order to facilitate the best possible practices. This study emphasises the importance of increasing knowledge of evidence-based practice in the social sector, and the need to further investigate how research methods and evidence-based practice concepts are translated into practice.
A Workplace Dignity Perspective on Resilience: Moving Beyond Individualized Instrumentalization to Dignified Resilience
Authors: Bal Matthijs , Kordowicz Maria , Brookes Andy 
Published: September 2020

The Problem Resilience discourses in society and the contemporary workplace tend to emphasize the self-directed nature of resilience and the imposed demand for resilience for survival in the contemporary labor market. The Solution In this article, the anchoring point of resilience is analyzed when conceptualized within a neoliberal and self-directed ideology. Subsequently, it offers an alternative anchoring point through a dignity-perspective on resilience, through which the term is reinterpreted in a new meaning. The Stakeholders This article offers scholars, practitioners and policy-makers insights into how resilience can be conceptualized and used in practice. Analyzing resilience through a dignity lens provides new meanings and more effective uses of resilience in society and the contemporary workplaces.
Effect of miR-184 on Proliferation and Apoptosis of Pancreatic Ductal Adenocarcinoma and Its Mechanism
Authors: Li Shentao , Li He , Ge Weiwei , Song Kai , Yuan Chunyu , Yin Ran 
Published: September 2020

Objective: Previous studies have shown that abnormal expression of microRNA-184 leads to a variety of cancers, including pancreatic ductal adenocarcinoma, suggesting microRNA-184 as a new treatment target for pancreatic ductal adenocarcinoma. However, the molecular mechanism of microRNA-184 in pancreatic ductal adenocarcinoma remains unclear. It is important to investigate the effect and role of microRNA-184 in pancreatic ductal adenocarcinoma. Methods: The clinical and laboratory inspection data of 120 patients with pancreatic cancer admitted to the First Affiliated Hospital of Anhui Medical University were compared. MicroRNA-184 expression in tumor tissues and cells was evaluated using reverse transcription polymerase chain reaction. Flow cytometry and Annexin V/propidium iodide staining were performed to examine cell cycle and apoptosis. Western blotting analysis was conducted to measure the protein expression of p-PI3K, p-AKT, JNK1, C-Myc, C-Jun, caspase-9, and caspase-3. Results: MicroRNA-184 expression was low in patients with pancreatic ductal adenocarcinoma. Survival curve showed that patients with lower expression of microRNA-184 in tumor tissues had a worse prognosis and shorter survival time ( P < .05), and the multivariate analysis identified that microRNA-184 was an independent prognostic indicator ( P < .05). In vitro studies showed that microRNA-184 overexpression induced apoptosis and suppressed cell cycle transition from G1 to S and G2 phases in pancreatic ductal adenocarcinoma cells. Furthermore, molecular studies revealed that inhibition of microRNA-184 promoted the gene expression of p-PI3K, p-AKT, JNK1, C-Myc, and C-Jun compared with the control group. Overexpression of microRNA-184 led to significantly increased expression of caspase-9 and caspase-3 and significantly decreased expression of Bcl-2. Conclusion: This study suggests that microRNA-184 inhibits the proliferation and promotes the apoptosis of pancreatic ductal adenocarcinoma cells by downregulating the expression of C-Myc, C-Jun, and Bcl-2. Our verification of the role of microRNA-184 may provide a novel biomarker for the diagnosis, therapy, and prognosis of pancreatic ductal adenocarcinoma.
A Qualitative Exploration of Barriers and Facilitators to Physical Activity Among Low-Income Latino Adolescents
Authors: Vasquez Taylor , Fernandez Alicia , Haya-Fisher Julissa , Kim Sarah , Beck Amy L 
Published: September 2020

Introduction: Latino adolescents experience high rates of obesity and physical activity can protect against obesity and obesity comorbidities. Health interventions to promote physical activity are more likely to be successful if they take into account the experiences and perspectives of their target population. Our study objective was to explore barriers and facilitators to physical activity among Latino adolescents with the goal of informing future interventions for this population. Method: Semistructured interviews were conducted with ( n = 30) low-income, Latino adolescents. The interviews were analyzed using inductive methods and the Capability–Opportunity–Motivation model of behavior. Results: Adolescents described capability gaps including lacking skills for preferred activities. School physical education and parks provided opportunities for adolescents to be physically active. Adolescents also described opportunity challenges, including age limits, not being able to afford preferred classes, and safety concerns. Families provided role modeling but rarely engaged in activities with adolescents. Adolescents were motivated to engage in physical activity but often lacked the necessary resources. Conclusions: Interventions to increase physical activity among urban Latino adolescents should offer tailored programming, incorporate families, enhance physical education, and improve the safety and appeal of recreational facilities.
PIM-1 may function as an oncogene in cervical cancer via activating the EGFR signaling
Authors: Yang Hongwen , He Kui , Dong Weile , Fang Jinchuan , Zhong Suyun , Tang Lixia , Long Lihua 
Published: September 2020

Background: This work was designed to explore the roles of PIM-1 in the development of cervical cancer. Methods: There were 90 paired cervical tumor samples and the non-tumor adjacent tissue. The levels of PIM-1 in different samples were examined using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) methods. The potential diagnostic value of PIM-1 was analyzed by the receiver operating characteristic (ROC) curve; furthermore, the expression of EGFR in tumor samples was detected, and Pearson’s correlation analysis was performed to analyze the relationship between the expression of PIM-1 and EGFR. Finally, cervical cancer cell line Hela cells were cultured and treated by PIM-1 siRNA, and MTT assay and Pi/Annexin V assay were performed to explore the effects of PIM-1 siRNA on the growth and apoptosis ability of the Hela cells. Results: PIM-1 was significantly up-regulated in cervical cancer tissue compared to adjacent tissue, and the expression of PIM-1 in patients with cervical cancer is positively associated with the size and metastasis of the tumor. ROC analysis showed PIM-1 is a sensitive biomarker for the diagnosis of cervical cancer. Furthermore, EGFR was over-expressed in cervical cancer tumor tissues, and the levels of PIM-1 and EGFR in cervical cancer tissue were positively correlated. Finally, PIM-1 siRNA dramatically inhibited the viability and promoted the apoptosis of the Hela cells. Conclusion: Our findings prove that PIM-1 may function as an oncogene in cervical cancer and can regulate the EGFR signaling in cervical cancer.
Safe and Sufficient Glycemic Control by Using a Digital Clinical Decision Support System for Patients With Type 2 Diabetes in a Routine Setting on General Hospital Wards
Authors: Lichtenegger Katharina M. , Aberer Felix , Tuca Alexandru C. , Donsa Klaus , Höll Bernhard , Schaupp Lukas , Plank Johannes , Beck Peter , Fruhwald Friedrich M , Kamolz Lars-Peter , Pieber Thomas R. , Mader Julia K. 
Published: September 2020

The aim was to investigate the applicability of a clinical decision support system in a real-world inpatient setting for patients with type 2 diabetes on general hospital wards. A total of 150 patients with type 2 diabetes requiring subcutaneous insulin therapy were treated with basal-bolus insulin therapy guided by a decision support system (GlucoTab) providing automated workflow tasks and suggestions for insulin dosing to health care professionals. By using the system, a mean daily blood glucose (BG) of 159 ± 32 mg/dL was achieved. 68.8% of measurements were in the target range (70 to <180 mg/dL). The percentage of BG values <40, <70, and ≥300 mg/dL was 0.02%, 2.2%, and 2.3%, respectively. Health care professionals’ adherence to suggested insulin doses and workflow tasks was high (>93% and 91%, respectively). The decision support system facilitates safe and efficacious inpatient diabetes care by standardizing treatment workflow and providing decision support for basal-bolus insulin dosing.
Success factors in high-effect, low-cost eHealth programs for patients with hypertension: a systematic review and meta-analysis
Authors: Blok Sebastiaan , van der Linden Eva L , Somsen G Aernout , Tulevski Igor I , Winter Michiel M , van den Born Bert-Jan H 
Published: September 2020

Abstract

Background
eHealth programs can lower blood pressure but also drive healthcare costs. This study aims to review the evidence on the effectiveness and costs of eHealth for hypertension and assess commonalities in programs with high effect and low additional cost.

Results
Overall, the incremental decrease in systolic blood pressure using eHealth, compared to usual care, was 3.87 (95% confidence interval (CI) 2.98–4.77) mmHg at 6 months and 5.68 (95% CI 4.77–6.59) mmHg at 12 months’ follow-up. High intensity interventions were more effective, resulting in a 2.6 (95% CI 0.5–4.7) (at 6 months) and 3.3 (95% CI 1.4–5.1) (at 12 months) lower systolic blood pressure, but were also more costly, resulting in €170 (95% CI 56–284) higher costs at 6 months and €342 (95% CI 128–556) at 12 months. Programs that included a high volume of participants showed €203 (95% CI 99–307) less costs than those with a low volume at 6 months, and €525 (95% CI 299–751) at 12 months without showing a difference in systolic blood pressure. Studies that implemented eHealth as a partial replacement, rather than addition to usual care, were also less costly (€119 (95% CI –38–201 at 6 months) and €346 (95% CI 261–430 at 12 months)) without being less effective. Evidence on eHealth programs for hypertension is ambiguous, heterogeneity on effectiveness and costs is high (I2 = 56–98%).

Conclusion
Effective eHealth with limited additional costs should focus on high intensity interventions, involve a large number of participants and use eHealth as a partial replacement for usual care.
Health information seeking behaviour using mobile devices among people with diabetes: A comparison between Middle and high income country
Authors: Lee Jason WY , Theng Yin-Leng , Lee Shaun WH 
Published: September 2020

Objective The internet has become a primary source of information for many individuals especially those with chronic diseases. This study aims to understand and compare the health seeking behaviour using mobile devices among individuals with diabetes and between a high (Singapore) and middle (Malaysia) income country. Methods A cross sectional survey was conducted among people with diabetes in Malaysia and Singapore. Participants attending the primary health clinic for the treatment of diabetes were approached to participate in this survey. Data on demographics, health status and beliefs to health were collected and compared. Results A total of 673 respondents were included in the study. Most of the respondents reported to have access to the Internet, with a high ownership of mobile phones (99.3%). However, only one in every three respondents sought information online. Younger individuals (≤50 years) and those with higher education more likely to seek information using mobile devices. Respondents in Singapore reported to be more likely to use mobile devices to monitor their health as compared to respondents in Malaysia. However, most respondents would seek health information from their healthcare professionals’ especially physicians. Conclusion There was limited differences in the health-seeking behaviour among the respondents from both countries, suggesting for a need to identify for more effective means of distribution of health related information.
“They Would Do Just Fine Without Me”: Experiences of Private Tutoring in Denmark
Authors: Cone Lucas 
Published: September 2020

Purpose: Building on a qualitative case study of parents and tutors previously involved with a large commercial tutoring company, this article investigates experiences of private tutoring in Denmark. Design/Approach/Methods: The case study centers around an affective analysis of eight interviews—three parents and five tutors—centering on why and how the interlocutors decided to hire services from or work for the tutoring company. Findings: The article illustrates how the parents’ and tutors’ experiences of private tutoring are colored by a series of affective patterns that set the tone for how the parents and tutors make sense of and feel about the phenomenon. Three patterns are drawn forth which together sustain the “mood” in which the parents and tutors encounter the tutoring phenomenon: teacher intimacy, institutional professionalism, and nonexclusivity. Originality/Value: The article provides an empirically grounded perspective on the stakes of commercializing education in spaces characterized by egalitarian ideals in education.
Factors Affecting the Decision to Initiate Anticoagulation After Spine Surgery: Findings From the AOSpine Anticoagulation Global Initiative
Authors: Gandhi Sapan D. , Khanna Krishn , Harada Garrett , Louie Philip , Harrop James , Mroz Thomas , Al-Saleh Khalid , Brodano Giovanni Barbanti , Chapman Jens , Fehlings Michael G. , Hu Serena S. , Kawaguchi Yoshiharu , Mayer Michael , Menon Venugopal , Park Jong-Beom , Rajasekaran Shanmuganathan , Valacco Marcelo , Vialle Luiz , Wang Jeffrey C. , Wiechert Karsten , Riew K. Daniel , Samartzis Dino 
Published: September 2020

Study Design: Cross-sectional, international survey. Objectives: To identify factors influencing pharmacologic anticoagulation initiation after spine surgery based on the AOSpine Anticoagulation Global Survey. Methods: This survey was distributed to the international membership of AOSpine (n = 3805). A Likert-type scale described grade practice-specific factors on a scale from low (1) to high (5) importance, and patient-specific factors a scale from low (0) to high (3) importance. Analysis was performed to determine which factors were significant in the decision making surrounding the initiation of pharmacologic anticoagulation. Results: A total of 316 spine surgeons from 64 countries completed the survey. In terms of practice-specific factors considered to initiate treatment, expert opinion was graded the highest (mean grade ± SD = 3.2 ± 1.3), followed by fellowship training (3.2 ± 1.3). Conversely, previous studies (2.7 ± 1.2) and unspecified guidelines were considered least important (2.6 ± 1.6). Patient body mass index (2.0 ± 1.0) and postoperative mobilization (2.3 ± 1.0) were deemed most important and graded highly overall. Those who rated estimated blood loss with greater importance in anticoagulation initiation decision making were more likely to administer thromboprophylaxis at later times (hazard ratio [HR] = 0.68-0.71), while those who rated drain output with greater importance were likely to administer thromboprophylaxis at earlier times (HR = 1.32-1.43). Conclusion: Among our global cohort of spine surgeons, certain patient factors (ie, patient mobilization and body mass index) and practice-specific factors (ie, expert opinion and fellowship training) were considered to be most important when considering anticoagulation start times.
Factors Related to Pain in Patients With Retorn Rotator Cuffs: Early Postoperative Pain Predicts Pain at 12 Months Postoperatively
Authors: Kim Yang-Soo , Kang Ki-Ho , Lee Hyo-Jin 
Published: September 2020

Background: Retearing of a repaired rotator cuff leads to diverse symptoms, including pain, regardless of the degree of the tear, but the relationship between pain and retears is poorly understood. Purpose: To determine which factors are correlated with shoulder pain in retears of a repaired rotator cuff. Study Design: Case-control study; Level of evidence, 3. Methods: We retrospectively reviewed a cohort of patients who were diagnosed as having a retear on magnetic resonance imaging after primary rotator cuff repair. The primary outcome variable of interest was the visual analog scale (VAS) for pain score at 12-month and final follow-up (mean, 25.2 months). We evaluated the relationship of pain at 12-month and final follow-up with preoperative patient factors (age, sex, and underlying conditions), preoperative range of motion, and preoperative pain; postoperative pain at 3 and 6 months; and perioperative conditions (tear extent, tear size, accompanying lesions, and procedures other than rotator cuff repair). Results: A total of 48 patients were reviewed. The VAS score at 3 months postoperatively showed a positive correlation with the VAS score at 12 months postoperatively (ρ = 0.537; P < .001) and at final follow-up (ρ = 0.537; P < .001). Univariate and multivariate regression analyses revealed that the VAS score at 3 months postoperatively ( P = .0001 and P = .0017, respectively), hypertension ( P = .0108 and P = .0073, respectively), and late detection of the retear ( P = .0091 and P = .0208, respectively) were significant predictors of pain at 12 months postoperatively. Conclusion: The presence of pain in the early postoperative period, underlying hypertension, and late detection of the retear were related to pain severity in patients 12 months after rotator cuff surgery.