bluuebunny/crossref_metadata_2025_split huggingface dataset:
A valuable cardiac magnetic resonance investigation after MINOCA/takotsubo Syndrome: a case report
Authors: Pradhan Snehasis , Zalloum Nedall , Kciku Gresa , Trappe Hans‐Joachim 
Published: September 2020

AbstractMyocardial infarction with non‐obstructive coronary arteries is a working diagnosis that includes takotsubo cardiomyopathy/syndrome (TTS). Cardiac magnetic resonance (CMR) is useful for establishing the underlying aetiology of myocardial infarction with non‐obstructive coronary arteries during the acute phase, but its role in follow‐up is less well established. A 35‐year‐old man with several cardiac risk factors presented 3 days after his sister's death with biochemical and clinical features of acute myocardial infarction without coronary artery obstruction on angiography but with diagnostic features of TTS on CMR, including oedema but no late gadolinium enhancement. Subsequent CMR 3 months later revealed left ventricular late gadolinium enhancement suggesting previous acute myocardial infarction. Although the initial diagnosis of TTS was robust according to established criteria, it remained uncertain whether the later ischaemic injury was related to an ischaemic event at presentation or occurred in the intervening period. Nevertheless, CMR may have an extended role in the follow‐up of these patients and may reveal additional, actionable pathology.
NT‐pro‐BNP in patients with left ventricular hypertrabeculation/non‐compaction
Authors: Rapatz Katharina , Finsterer Josef , Voill‐Glaninger Astrid , Wilfinger‐Lutz Nastasia , Winkler‐Dworak Maria , Stöllberger Claudia 
Published: September 2020

AbstractAimsLeft ventricular hypertrabeculation/non‐compaction (LVHT) is a cardiac abnormality of unknown pathogenesis and frequently associated with neuromuscular disorders. The N‐terminal fragment of the pro brain natriuretic peptide (NT‐pro‐BNP) is a prognostic marker in heart failure whose relevance in LVHT patients is largely unknown. The aim of the study was to assess the role of NT‐pro‐BNP levels as prognostic markers in LVHT.Methods and resultsData of LVHT patients were collected in a database from one echocardiographic laboratory since 1996. The hospital information system was screened for measurements of NT‐pro‐BNP levels, and their association with clinical and echocardiographic baseline parameters was retrospectively assessed. During follow‐up, the endpoints were death and heart transplantation. In 113 patients (median age 57 years, 24% women), data about NT‐pro‐BNP measurements were found, ranging from 8 to 121 152 (median 2029) ng/L. High NT‐pro‐BNP levels were associated with heart failure, valvular abnormalities, diabetes mellitus, hypertension, angina pectoris, number of LVHT‐affected segments, end‐diastolic diameter, and systolic dysfunction. During a follow‐up of 73 (±64; 0–237) months, 35% of the patients reached an endpoint. High NT‐pro‐BNP levels were associated with the occurrence of an endpoint (P < 0.001). By multivariate analysis, predictors for endpoints were increased age (P = 0.0025), atrial fibrillation (P = 0.0023), natural logarithm of NT‐pro‐BNP levels (P = 0.0073), diabetes mellitus (P = 0.014), and thromboembolic events before diagnosis (P = 0.0347).ConclusionsAlso in LVHT patients, high NT‐pro‐BNP levels are indicators for death and heart transplantation.
A rise in left atrial pressure detected by the V‐LAP™ system for patients with heart failure during the coronavirus disease 2019 pandemic
Authors: Perl Leor , Ben Avraham Binyamin , Vaknin‐Assa Hana , Ben Gal Tuvia , Kornowski Ran 
Published: September 2020

AbstractDuring the coronavirus disease 2019 (COVID‐19) pandemic, many patients refrained from inpatient medical care. For those inflicted with heart failure (HF), the risk of repeat hospitalizations is particularly high in case of infection. This presents an important opportunity for remote monitoring of haemodynamic data for these patients, in order to detect and treat accordingly. The aim of the present case is to report of the first measurements of a novel wireless left atrial pressure (LAP) monitoring system, the V‐LAP™ (Vectorious Medical Technologies, Ltd), during the COVID‐19 pandemic. The V‐LAP™ Left Atrium Monitoring systEm for Patients With Chronic sysTOlic & Diastolic Congestive heart Failure (VECTOR‐HF) is a first‐in‐man clinical study assessing the safety and feasibility of the V‐LAP™ monitoring system. Our first patient, a 59‐year‐old man with severe ischaemic cardiomyopathy (left ventricular ejection fraction −30%) was enrolled prior to the COVID‐19 outbreak. As per protocol, both the patient and the medical team were blinded to the results in the first 3 months after implantation. We were able to witness the LAP during the pandemic, as the patient remained undertreated, demonstrating a gradual increase from a mean pressure of 6.56 to 19.4 mmHg, as well as prominent V waves, before the data became available to the medical team and the patient was treated accordingly. Thereafter, pressures have returned to low values. This case demonstrated the feasibility of remote monitoring of LAP using the V‐LAP™ system, as well as the potential benefit of remote care of HF patients.
Hierarchical Porous Tubular Biochar Based Sensor for Detection of Trace Lead (II)
Authors: Chen Xue , Lu Kunchao , Lin Donghai , Li Yan , Yin Shiyu , Zhang Zhiyi , Tang Meihua , Chen Guosong 
Published: September 2020

AbstractHierarchical porous tubular biochar (PTBC) was prepared by selectively removing lignin simply according to reverse the pyrolysis sequence of cellulose. The properties of the PTBC sample were characterized by XRD, SEM, TEM, Raman spectra, cyclic voltammetry and electrochemical impedance spectroscopy. The electrochemical performances of PTBC modified on the screen‐printing electrode illustrated excellent detection of lead ions (lead (II)) in water with the linear range (0.5–120 μg/L) and the detection limit (0.02 μg/L) by in‐situ bismuth film square wave anode stripping voltammetry.
Combining boundary‐conforming finite element meshes on moving domains using a sliding mesh approach
Authors: Helmig Jan , Key Fabian , Behr Marek , Elgeti Stefanie 
Published: September 2020

AbstractFor most finite element simulations, boundary‐conforming meshes have significant advantages in terms of accuracy or efficiency. This is particularly true for complex domains. However, with increased complexity of the domain, generating a boundary‐conforming mesh becomes more difficult and time consuming. One might therefore decide to resort to an approach where individual boundary‐conforming meshes are pieced together in a modular fashion to form a larger domain. This article presents a stabilized finite element formulation for fluid and temperature equations on sliding meshes. It couples the solution fields of multiple subdomains whose boundaries slide along each other on common interfaces. Thus, the method allows to use highly tuned boundary‐conforming meshes for each subdomain that are only coupled at the overlapping boundary interfaces. In contrast to standard overlapping or fictitious domain methods the coupling is broken down to few interfaces with reduced geometric dimension. The formulation consists of the following key ingredients: the coupling of the solution fields on the overlapping surfaces is imposed weakly using a stabilized version of Nitsche's method. It ensures mass and energy conservation at the common interfaces. Additionally, we allow to impose weak Dirichlet boundary conditions at the nonoverlapping parts of the interfaces. We present a detailed numerical study for the resulting stabilized formulation. It shows optimal convergence behavior of the interface coupling for both Newtonian and generalized Newtonian material models. Simulations of flow of plastic melt inside single‐screw as well as twin‐screw extruders demonstrate the applicability of the method to complex and relevant industrial applications.
Combination of beneficial bacteria improves blueberry production and soil quality
Authors: Yu Yi‐Yang , Xu Jing‐Da , Huang Tao‐Xiang , Zhong Jian , Yu Hong , Qiu Jing‐Ping , Guo Jian‐Hua 
Published: September 2020

AbstractBlueberry is an important agricultural crop with high nutritional, health, and economic value. Despite the well‐studied blueberry cultivation methods and soil requirements, little is known about how beneficial bacteria function in organic blueberry cultivation systems and their effects on acidic soils. In this study, a single bacteria Bacillus amyloliquefaciens JC65 and three biocontrol bacteria consortiums containing JC65 were applied to organic system. The effect of bacteria to blueberry growth, yield, fruit quality, and soil quality was investigated. A consortium of three mixed Bacillus (B. amyloliquefaciens JC65, B. licheniforims HS10 and B. subtilis 7ze3) showed the highest growth improvement efficiency. The bacterial inoculation increased blueberry leaf chlorophyll content, net photosynthetic rate by 21.50%, 13.21% at 30 days, and increased average plant height by 2.72% at 69 days. Compared with the control, the inoculated plants showed an increased yield of 14.56%. Interestingly, blueberry fruit quality was also improved with supplement of the bacterial consortium. Fruit anthocyanin, soluble sugar, vitamin C, soluble solids, and soluble protein content were increased by 5.99%, 4.21%, 17.31%, 2.41%, and 21.65%, respectively. Besides, beneficial bacterial consortium also enables sustainable agriculture by improving soil ammonium nitrogen and organic matter by 3.77% and 2.96% after blueberry planting. In conclusion, the combination of beneficial bacteria showed a synergistic activity in organic system to promote the blueberry yield, fruit quality, and soil nutrient preservation.
Loci identified by a genome‐wide association study of carotid artery stenosis in the eMERGE network
Authors: Palmer Melody R. , Kim Daniel S. , Crosslin David R. , Stanaway Ian B. , Rosenthal Elisabeth A. , Carrell David S. , Cronkite David J. , Gordon Adam , Du Xiaomeng , Li Yatong K. , Williams Marc S. , Weng Chunhua , Feng Qiping , Li Rongling , Pendergrass Sarah A. , Hakonarson Hakon , Fasel David , Sohn Sunghwan , Sleiman Patrick , Handelman Samuel K. , Speliotes Elizabeth , Kullo Iftikhar J. , Larson Eric B. ,   The eMERGE Consortium, Jarvik Gail P. 
Published: September 2020

AbstractCarotid artery atherosclerotic disease (CAAD) is a risk factor for stroke. We used a genome‐wide association (GWAS) approach to discover genetic variants associated with CAAD in participants in the electronic Medical Records and Genomics (eMERGE) Network. We identified adult CAAD cases with unilateral or bilateral carotid artery stenosis and controls without evidence of stenosis from electronic health records at eight eMERGE sites. We performed GWAS with a model adjusting for age, sex, study site, and genetic principal components of ancestry. In eMERGE we found 1793 CAAD cases and 17,958 controls. Two loci reached genome‐wide significance, on chr6 in LPA (rs10455872, odds ratio [OR] (95% confidence interval [CI]) = 1.50 (1.30–1.73), p = 2.1 × 10−8) and on chr7, an intergenic single nucleotide variant (SNV; rs6952610, OR (95% CI) = 1.25 (1.16–1.36), p = 4.3 × 10−8). The chr7 association remained significant in the presence of the LPA SNV as a covariate. The LPA SNV was also associated with coronary heart disease (CHD; 4199 cases and 11,679 controls) in this study (OR (95% CI) = 1.27 (1.13–1.43), p = 5 × 10−5) but the chr7 SNV was not (OR (95% CI) = 1.03 (0.97–1.09), p = .37). Both variants replicated in UK Biobank. Elevated lipoprotein(a) concentrations ([Lp(a)]) and LPA variants associated with elevated [Lp(a)] have previously been associated with CAAD and CHD, including rs10455872. With electronic health record phenotypes in eMERGE and UKB, we replicated a previously known association and identified a novel locus associated with CAAD.
Liver Injury in Liver Transplant Recipients With Coronavirus Disease 2019 (COVID‐19): U.S. Multicenter Experience
Authors: Rabiee Atoosa , Sadowski Brett , Adeniji Nia , Perumalswami Ponni V. , Nguyen Veronica , Moghe Akshata , Latt Nyan L. , Kumar Sonal , Aloman Costica , Catana Andreea M. , Bloom Patricia P. , Chavin Kenneth D. , Carr Rotonya M. , Dunn Winston , Chen Vincent L. , Aby Elizabeth S. , Debes Jose D. , Dhanasekaran Renumathy ,   on behalf of the COLD Consortium
Published: September 2020

Background and Aims
Coronavirus disease 2019 (COVID‐19) is associated with liver injury, but the prevalence and patterns of liver injury in liver transplantation (LT) recipients with COVID‐19 are open for study.

Approach and Results
We conducted a multicenter study in the United States of 112 adult LT recipients with COVID‐19. Median age was 61 years (interquartile range, 20), 54.5% (n = 61) were male, and 39.3% (n = 44) Hispanic. Mortality rate was 22.3% (n = 25); 72.3% (n = 81) were hospitalized and 26.8% (n = 30) admitted to the intensive care unit (ICU). Analysis of peak values of alanine aminotransferase (ALT) during COVID‐19 showed moderate liver injury (ALT 2‐5× upper limit of normal [ULN]) in 22.2% (n = 18) and severe liver injury (ALT > 5× ULN) in 12.3% (n = 10). Compared to age‐ and sex‐matched nontransplant patients with chronic liver disease and COVID‐19 (n = 375), incidence of acute liver injury was lower in LT recipients (47.5% vs. 34.6%; P = 0.037). Variables associated with liver injury in LT recipients were younger age (P = 0.009; odds ratio [OR], 2.06; 95% confidence interval [CI], 1.20‐3.54), Hispanic ethnicity (P = 0.011; OR, 6.01; 95% CI, 1.51‐23.9), metabolic syndrome (P = 0.016; OR, 5.87; 95% CI, 1.38‐24.99), vasopressor use (P = 0.018; OR, 7.34; 95% CI, 1.39‐38.52), and antibiotic use (P = 0.046; OR, 6.93; 95% CI, 1.04‐46.26). Reduction in immunosuppression (49.4%) was not associated with liver injury (P = 0.156) or mortality (P = 0.084). Liver injury during COVID‐19 was significantly associated with mortality (P = 0.007; OR, 6.91; 95% CI, 1.68‐28.48) and ICU admission (P = 0.007; OR, 7.93; 95% CI, 1.75‐35.69) in LT recipients.

Conclusions
Liver injury is associated with higher mortality and ICU admission in LT recipients with COVID‐19. Hence, monitoring liver enzymes closely can help in early identification of patients at risk for adverse outcomes. Reduction of immunosuppression during COVID‐19 did not increase risk for mortality or graft failure.
Safety and bleeding patterns of the levonorgestrel 52‐mg intrauterine system among women with thrombosis or coagulopathy
Authors: Brull Eliza P. , Fernandes Arlete , Monteiro Ilza , Bahamondes Luis , Juliato Cassia R. T. 
Published: September 2020

AbstractObjectiveTo assess the safety of the levonorgestrel 52‐mg intrauterine system (LNG‐IUS) in women with a history of thrombosis or coagulopathy and to evaluate bleeding patterns.MethodsA retrospective chart review was conducted of 117 women attending a clinic between 2007 and 2019. Their sociodemographic characteristics, hematologic status, reasons for using LNG‐IUS, duration of use, use of oral anticoagulants, complications, and bleeding patterns were analyzed.ResultsNinety‐nine women had a history of thrombosis (71.7% in use of oral anticoagulants) and 18 had coagulopathies. No bleeding or any other complications occurred during placement of the LNG‐IUS. Around two‐thirds of the women reported amenorrhea or oligomenorrhea at 12, 24, and 54 months of follow‐up, with no difference between the groups using the IUS for contraception or to treat heavy menstrual bleeding (HMB) (P=0.07), those with a history of thrombosis or coagulopathy (P=0.53), and users or non‐users of oral anticoagulants (P=0.59).ConclusionThe LNG‐IUS is safe for women with hematologic disorders. It was associated with amenorrhea or oligomenorrhea in a large proportion of users up to 54 months of follow‐up regardless of use of oral anticoagulants, reason for use of LNG‐IUS (contraception or HMB), or history of coagulopathy or thrombosis.
Recovery after enhanced versus conventional care laparoscopic hysterectomy performed in the afternoon: A randomized controlled trial
Authors: Kilpiö Olga , Härkki Päivi S. M. , Mentula Maarit J. , Väänänen Antti , Pakarinen Päivi I. 
Published: September 2020

AbstractObjectiveTo compare enhanced recovery after surgery (ERAS) and conventional care (CC) protocols on outcomes of laparoscopic hysterectomy (LH) performed in the afternoon.MethodsA single‐center randomized controlled trial was conducted on 120 women undergoing LH who were randomly divided into the intervention group (IG; n=60) and control group (CG; n=60). Women in the IG were treated according to the ERAS protocol and those in the CG according to the CC protocol. The primary outcome was the length of hospitalization. Secondary outcomes were postoperative opioid use, postoperative pain and emesis, complications, operative bleeding, and time.ResultsMore women discharged during 24 hours in the IG than in the CG (88% vs 55%, P<0.001). The time to actual discharge (19 vs 22 hours, P<0.001) and ready‐to‐discharge time (15 vs 21 hours, P<0.001) were shorter and the use of oxycodone was lower (0 mg [0–0 vs 2.5 mg [0–10], P<0.001) in the IG than in the CG, respectively. Otherwise, no other significant differences between the groups were observed. The follow‐up time was one month.ConclusionThe ERAS protocol reduces hospital stay and decreases the use of opioids with no impairment in surgical outcome of LH.ClinicalTrials.gov: NCT03828981.
Low‐intensity pulsed ultrasound promotes the formation of periodontal ligament stem cell sheets and ectopic periodontal tissue regeneration
Authors: Li Han , Zhou Jie , Zhu Mengyuan , Ying Siqi , Li Lingjie , Chen Duanjing , Li Jie , Song Jinlin 
Published: September 2020

AbstractHuman periodontal ligament stem cells (hPDLSCs) sheets play an important role in periodontal tissue engineering. Low‐intensity pulsed ultrasound (LIPUS) has been reported as an effective stimulus to regulate cell biological behavior. The present study aims to explore the potential of LIPUS to promote the formation and function of hPDLSC sheets (hPDLSCSs). Hematoxylin–eosin (H&E) staining, western blot, real‐time PCR, alkaline phosphatase (ALP), and alizarin red staining were used to evaluate the formation and osteogenic effect of LIPUS on hPDLSCSs in vitro. Hydroxyapatite with or without hPDLSCSs was transplanted in the subcutaneous pockets on the back of nude mice and histological analysis was performed. H&E staining showed increased synthesis of extracellular matrix (ECM) and real‐time PCR detected a significant increase in ECM‐related genes after LIPUS treatment. In addition, LIPUS could promote the expression of osteogenic differentiation‐related genes and proteins. ALP and alizarin red staining also found LIPUS enhanced the osteogenesis of hPDLSCSs. After transplantation in vivo, more dense collagen fibers similar to periodontal ligament were regenerated. Collectively, these results indicate that LIPUS not only promotes the formation and osteogenic differentiation of hPDLSCSs but also is a potential treatment strategy for periodontal tissue engineering.
Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank
Authors: Raisi-Estabragh Zahra , Biasiolli Luca , Cooper Jackie , Aung Nay , Fung Kenneth , Paiva José M , Sanghvi Mihir M , Thomson Ross J , Curtis Elizabeth , Paccou Julien , Rayner Jennifer J , Werys Konrad , Puchta Henrike , Thomas Katharine E , Lee Aaron M , Piechnik Stefan K , Neubauer Stefan , Munroe Patricia B , Cooper Cyrus , Petersen Steffen E , Harvey Nicholas C 
Published: September 2020

ABSTRACT
Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, diabetes, and obesity. Furthermore, we considered whether associations with arterial compliance explained association of SOS with ischemic cardiovascular outcomes. Higher SOS was associated with lower arterial compliance by both ASI and AD for both men and women. The relationship was most consistent with ASI, likely relating to larger sample size available for this variable (n = 159,542 versus n = 18,229). There was no clear evidence of differential relationship by menopause, smoking, diabetes, or body mass index (BMI). Blood biomarkers appeared important in mediating the association for both men and women, but with different directions of effect and did not fully explain the observed effects. In fully adjusted models, higher SOS was associated with significantly lower IHD mortality in men, but less robustly in women. The association of SOS with ASI did not explain this observation. In conclusion, our findings support a positive association between bone and vascular health with consistent patterns of association in men and women. The underlying mechanisms are complex and appear to vary by sex. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Angiotensin‐(1‐7) prevents T3‐induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF‐ĸB
Authors: Senger Nathalia , C. Parletta Aline , Marques Bruno V. D. , Akamine Eliana H. , Diniz Gabriela P. , Campagnole‐Santos Maria J. , Santos Robson A. S. , Barreto‐Chaves Maria Luiza M. 
Published: September 2020

AbstractClinical studies have shown a correlation between thyroid disorders and cardiac diseases. High levels of triiodothyronine (T3) induce cardiac hypertrophy, a risk factor for cardiac complications and heart failure. Previous results have demonstrated that angiotensin‐(1‐7) is able to block T3‐induced cardiac hypertrophy; however, the molecular mechanisms involved in this event have not been fully elucidated. Here, we evidenced the contribution of FOXO3 signaling to angiotensin‐(1‐7) effects. Angiotensin‐(1‐7) treatment increased nuclear FOXO3 levels and reduced p‐FOXO3 levels (inactive form) in isolated cardiomyocytes. Knockdown of FOXO3 by RNA silencing abrogated the antihypertrophic effect of angiotensin‐(1‐7). Increased expression of antioxidant enzymes superoxide dismutase 1 (SOD1 and catalase) and lower levels of reactive oxygen species and nuclear factor‐κB (NF‐κB) were observed after angiotensin‐(1‐7) treatment in vitro. Consistent with these results, transgenic rats overexpressing angiotensin‐(1‐7) displayed increased nuclear FOXO3 and SOD1 levels and reduced NF‐κB levels in the heart. These results provide a new molecular mechanism responsible for the antihypertrophic effect of angiotensin‐(1‐7), which may contribute to future therapeutic targets.