bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balloon Occluded TACE (B-TACE) vs DEM-TACE for HCC. A Single Center Retrospective Case Control Study.
Authors: lucatelli Pierleone , De Rubeis Gianluca , Rocco Bianca , Basilico Fabrizio , Cannavale Alessandro , Abbatecola Aurelio , Nardis Pier Giorgio , Corona Mario , Brozzetti Stefania , Catalano Carlo , Bezzi Mario 
Published: October 2020

Abstract
Background To compare oncological results and safety profile of balloon micro-catheter trans-arterial chemoembolization (b-TACE) and drug-eluting-microsphere (DEM-TACE) in patients with hepatocellular-carcinoma (HCC).Methods This is a case-control, retrospective, single-center study. Between January-2015/March-2019, 149 patients (131 males [87.9%]) with 226 HCC were treated, 22 patients (35 HCC; 19 [86.4%] males) with b-TACE and 127 with DEM-TACE (191 HCC, 112 [88.2%] males). Embolization protocol was standardized (sequential 100±25 and 200±25 μm microspheres). Results were evaluated by modified-response-evaluation-criteria-in-solid-tumor [mRECIST] at 1, 3-6 and 9-12 months and time to recurrence after complete response [TTR] at 1 years. Cox’s regression weighted with tumor dimensions was performed. Adverse events (AEs) were recorded.Results mRECIST oncological response at all time points (1, 3-6 and 9-12 months) for both treatments were similar, with the exception of Objective response rate at 9-12months. Objective response at 1 and 3-6 months between b-TACE vs DEM-TACE [23/35 (65.7%) vs 119/191 (62.3%), 21/29 (72.4%) vs 78/136 (57.4%) (p>0.05), respectively]. On the contrary, at 9-12 months, it was significantly higher in b-TACE subgroup than DEM-TACE (15/19 [78.9%] vs 48/89 [53.9%], p=0.05). TTR for complete response at 1 year had a better trend for b-TACE vs DEM-TACE (278.0 days [196.0-342.0] vs 219.0 days [161.0-238.0], OR 0.68 [0.4-1.0], p=0.10). The use of balloon micro-catheter reduced the relative risk of the event of recurrence by 0.63 [CI95% 0.38-1.04]; p=0.07). No significant differences were found in AEs rate. Conclusion b-TACE showed a trend of better oncological response over DEM-TACE with and longer TTR with a similar adverse events rate, in patients presenting with larger tumors.
Breastfeeding Self-Efficacy and Its Relationship with the Perceived Stress and the Breastfeeding Performance in Iranian Mothers with Late Preterm Infants, 2019
Authors: Kahforoushan Akram , Hasanpour Shirin , Mirghafourvand Mojgan 
Published: October 2020

Abstract
BackgroundLate preterm infants suffer from many short-term and long-term problems after birth. The key factor in fighting these problems is effective breastfeeding. The present study aimedto determine the breastfeeding self-efficacy and its relationship with the perceived stress and breastfeeding performance in mothers with late preterm infants. MethodsIn this prospective study, 171 nursing mothers with late preterm infants born in Alzahra Medical Center of Tabriz, Iran, who met the conditions of this study were selected through convenience sampling. The Breastfeeding Self-Efficacy Scale-Short Form (BSES- SF) was employed to measure breastfeeding self-efficacy and 14-item Perceived Stress Scale (PSS14) was used to measure the perceived stress during 24 hours after giving birth and when the child was 4 months old the breastfeeding performance was measured by the standard breastfeeding performance questionnaire. The data were analyzed by Pearson and Spearman’s correlation tests, independent t-test, one-way ANOVA, and Multiple Linear Regression.ResultsThe mean (standard deviation) of breastfeeding self-efficacy equaled 50.0 (7.8) from the scores ranging between13-65 and the mean (standard deviation) of the perceived stress equaled to 26.5 (8.8) from the scores ranging between 0-56. The median (25-75 percentiles) of breastfeeding performance score in the mothers equaled 2.0 (1.0 to 3.0) from the scores ranging between 0-6. On the basis of multiple linear regression and through adjusting the personal-social characteristic, by increasing the score of the breastfeeding self-efficacy, the perceived stress was decreased to a statistically significant amount (B=-0.1, 95%CI=-0.3 to 0.0), however, there was no statistically significant relationship between breastfeeding self-efficacy and breastfeeding performance (p=0.418). ConclusionDue to the modifiable variability of breastfeeding self-efficacy and its role in perceived maternal stress, the development of appropriate strategies to further increase breastfeeding self-efficacy and provide more support to these mothers and infants is of particular importance.
Effects of season of birth and meteorological parameters on serum bilirubin levels during the early neonatal period: a retrospective chart review
Authors: Iijima Shigeo , Baba Toru , Kondo Miyuki , Fujita Tomoka , Ohishi Akira 
Published: October 2020

Abstract
Background: Neonatal jaundice can be influenced by many factors. Several studies have suggested that the severity of neonatal jaundice may vary with the season, but conclusive data on this issue are currently lacking. The aim of the present study was to establish whether serum bilirubin levels vary in healthy term neonates according to seasonal variation and meteorological factors.Methods: We retrospectively studied 3,344 healthy term neonates born between 2013 and 2018. Using the capillary technique, total serum bilirubin (TSB) levels were measured on the fourth day after birth. The monthly and seasonal variations in TSB levels and clinical and meteorological effects on TSB levels were assessed.Results: In the enrolled neonates, the median gestational age was 39.4 weeks, median birthweight was 3,025 g, and median TSB level was 195 µmol/L. The TSB level peaked in December and was the lowest in July, but the variation was not statistically significant. The TSB level was significantly higher in the cold season (October to March) than in the warm season (April to September; p=0.01). Comparing the seasonal differences according to sex, TSB levels were significantly higher in the cold season in male infants (p=0.001), whereas no significant difference was observed in female infants. In only the male population did a weakly negative but significant association exist between TSB levels and daily mean air temperature (r=-0.07, p=0.007); in the female population, no significant correlation was found between TSB levels and meteorological parameters.Conclusions: Season of birth appears to be an etiological factor in neonatal jaundice, with an additional influence of sex. However, the contradictions observed in various studies highlight the need for further research on this topic.
Symptomatic Aortitis at Giant Cell Arteritis Diagnosis: A Prognostic Factor of Aortic Event.
Authors: Espitia Olivier , Blonz Gautier , Urbanski Geoffrey , Landron Cédric , Connault Jerome , Lavigne Christian , Roblot Pascal , Maillot Francois , Audemard Alexandra , Artifoni Mathieu , Durant Cecile , Guyomarch Beatrice , Hamidou Mohamed , Magnant Julie , Agard Christian 
Published: October 2020

Abstract
Background Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications and no predictive factor has been identified so far. The aim of this study was to investigate factors associated with the risk of aortic complications in a cohort of GCA aortitis.Methods Data of all patients managed with aortitis (CT or 18 FDG PET) at the diagnosis of GCA in five hospitals from May 1998 and April 2019 were retrospectively collected. Clinical features were compared according to the presence of aortitis symptoms. The predictive factors of occurrence or aggravation of aortic structural abnormalities were investigated. Results One hundred and seventy-one patients with GCA aortitis were included; 55 patients (32 %) had symptoms of aortitis (dorsal/lumbar/abdominal pain, aortic insufficiency) at diagnosis. The median follow-up was 38 months. Aortic complications occurred after a median time of 32 months. There were 19 new aortic aneurysms or complications of aneurysm, and 5 dissections. Survival without aortic complication was significantly different between the symptomatic and non-symptomatic groups (Log rank, p=0.0003). In multivariate analysis the presence of aortitis symptoms at diagnosis (HR 15.1 [1.4; 158.1] p=0.02) was a predictive factor associated with the occurrence of aortic complications. Conclusion In this study, the presence of aortitis symptoms at the diagnosis of GCA aortitis was an independent predictive factor of occurrence of aortic complications during follow-up.
Increased Potential of Bone Formation With Intravenous Injection of Parathyroid Hormone-minicircle DNA&nbsp;Vector&nbsp;
Authors: Kim Jang-Woon , Park Narae , Kang Jaewoo , Kim Yena , Jung Hyerin , Ju Ji Hyeon 
Published: October 2020

Abstract
Background: Osteoporosis is usually treated with long-term usage of anti-osteoporotic agents. However, poor drug compliance and emerging side effects sometimes are limitations for the treatment of osteoporosis. Parathyroid hormone-related protein (PTHrP) is needed for normal bone formation and remodeling. We attempted a new method using minicircle vectors (mc) encoding PTHrP analogs. Methods: We generated mc encoding the infusion of PTHrP 1-34 with 107-139 (mc 1-34+107-139). Ovariectomized (OVX) model was induced in 12-week-old C57BL/6 female mice. mc 1-34+107-139 was administered three times weekly via intravenous injections. Results: mc 1-34+107-139 significantly increased bone formation compared with the OVX group and decreased the bone resorption. PTHrP mc DNA vector was effective in increasing the quality of trabecular bone structure. Conclusions: These results provide experimental evidence for the therapeutic potential of minicircle DNA vectors in OVX model. This study is a first attempted proof-of-concept gene therapy using minicircle vectors for the treatment of osteoporosis.
Spatio-Temporal Characteristics of Meteorological Drought Under Changing Climate in Semi-Arid Region of Northern Ethiopia
Authors: Yisehak Biniyam , Shiferaw Henok , Abrha Haftu , Gebremedhin Amdom , Hagos Haftom , Adhana Kelali 
Published: October 2020

Abstract
Background: Below-normal availability of water for a considerable period of time induces occurrence of drought. This paper investigates the characteristics of meteorological drought under changing climate. The meteorological drought was assessed using the Standardized Precipitation Index (SPI) and the Reconnaissance Drought Index (RDI). The climate change was also analyzed using delta based statistical downscaling approach of RCP 4.5 and RCP 8.5 in R software packages. Results: The result of climate change projections showed that the average annual minimum temperature will be increased by about 0.8-2.9°C. The mean annual maximum temperature will be also increased by 0.9-3.75 °C. The rainfall projection generally showed an increasing trend, it exhibited an average annual increase of 3.5-13.4 % over the study area. The drought projection showed that there would be extreme drought events in study area for the future (2018-2099). The SPI result indicates that drought will be occurred in the study area after 1-5 and 1-6 years under RCP 4.5 and 8.5 emission scenarios respectively and the RDI value also shows drought will occurred after 1-6 and 2-7 years under RCP 4.5 and RCP 8.5 emission scenarios respectively over the study area. Almost more than 72% of the current and future spatial coverage of drought in the study area will be affected by extreme drought, 22.3% severely and 5.57% also moderate drought.Conclusions: Therefore, the study helps to provide useful information for policy decision makers to implement different adaptation and mitigation measures of drought in the region.
Putative Genes Identified in Alkaloids Biosynthesis in Dendrobium officinale by Correlating the Contents of Main Bioactive Metabolites with Genes Expression between Protocorm-like Bodies and Leaves
Authors: Wang Zhaojian , Xing Shihai , Jiang Weimin , Liu Yingying , Meng Xiaoxi , Su Xinglong , Cao Mengyang , Wu Liping , Yu Nianjun , Peng Daiyin 
Published: October 2020

Abstract
Background: Dendrobium officinale, an endangered Chinese herb, has extensive therapeutic effects and contains bioactive ingredients including a large number of polysaccharides and alkaloids, and minimal flavonoids. Firstly, this study attempts to obtain the protocorm-like bodies of this plant through tissue culture to produce the main secondary metabolites whose distribution in each organelle and protocorm like bodies is analyzed. Then, analysis of the correlation between comparative transcriptome sequence and the metabolite content in different organs enables the discovery of putative genes encoding enzymes involved in the biosynthesis of polysaccharides and alkaloids, and flavonoids.Results: The optimum condition for protocorm-like bodies (PLBs) induction and propagation of D. officinale is established. For protocorm induction, we use the seed as the explant, and the optimum medium formula for PLBs propagation is 1/2 MS + α-NAA 0.5 mg·L-1 +6-BA 1.0 mg·L-1 + 2, 4-D 1.5-2.0 mg·L-1 + potato juice 100 g·L-1. The distribution of polysaccharides, alkaloids and flavonoids in D. officinale organs was clarified. Stems, PLBs and leaves have the highest content of polysaccharides, alkaloids and flavonoids, respectively. PLBs replace organs to produce alkaloids in D. officinale, and naringenin was only produced in stem. Hot water extraction (HWE) method was found outperforming the ultrasound-assisted extraction (UAE) method for polysaccharides from D. officinale. A comparative transcriptome analysis of the protocorm-like bodies and leaves of D. officinale showed genes encoding enzymes involved in polysaccharides, alkaloids and flavonoids biosynthetic pathway were differentially expressed. Putative genes encoding enzymes involved in polysaccharides, alkaloids and flavonoids synthetic pathway were identified. Notably, genes encoding enzymes of strictosidine beta-glucosidase, geissoschizine synthase and vinorine synthase in alkaloids biosynthesis of D. officinale are first reported.Conclusions: Our works, especially the identification of candidate genes encoding enzymes involved in metabolites biosynthesis will help to explore and protect the endangered genetic resources and will also facilitate further analysis of the molecular mechanism of secondary metabolites’ biosynthesis in D. officinale.
Concordance in reports of food insecurity associated with environmental factors among Latino fathers and mothers
Authors: Nagao-Sato Sayaka , Druziako Stephanie , Baltaci Aysegul , Reyes Alejandro Omar Peralta , Zhang Youjie , Choque Ghaffar Ali Hurtado , Reicks Marla 
Published: October 2020

Abstract
Background: Food assistance and nutrition education are strategies used to address the high prevalence of food insecurity among U.S. Latino households. Assessment of food security status is necessary to implement these strategies. However, similarities and differences in perceptions of food security status have not been reported among Latino fathers and mothers who may have different home food acquisition and preparation responsibilities. This study aimed to 1) determine demographic characteristics and/or food-related factors associated with perceptions of food security status among Latino fathers and mothers, and 2) identify those factors correlated with concordance in perceptions of food insecurity between fathers and mothers.Methods: Baseline data were used from a Latino-family, community-based program to improve paternal parenting practices and youth energy balance-related behaviors (Padres Preparados, Jóvenes Saludables), including 106 father and mother couples. Food security was assessed with two questions from the U.S. Department of Agriculture 18-item Household Food Security Survey. Logistic regression models were used to evaluate associations between food security and predictor variables in fathers or mothers and between couple discordant responses in food security status and predictor variables.Results: The prevalence of household food insecurity was reported by 39% of fathers and 55% of mothers. Food security status was associated with neighborhood safety (odds ratio (OR): 3.7, p < 0.05) and household income (OR: 3.2, p < 0.05) in fathers, and with neighborhood safety (OR: 4.1, p < 0.01) and home fruit and vegetable availability (OR: 5.5, p < 0.01) in mothers. Couple discordance in reporting food security status occurred in 24% of the couples and was related to higher discordance among couples where fathers reported a lower frequency of participation in nutrition education than mothers (OR: 3.4, p < 0.05) and different perceptions of home fruit and vegetable accessibility (OR: 3.1, p < 0.05).Conclusions: Among Latino fathers and/or mothers, factors associated with perceptions of food insecurity differed, possibly related to fathers versus mothers having access to information about different household aspects related to food insecurity. Nutrition education for fathers may support an improvement in couple discordance in assessment of food security.
Simultaneous cardiac and lung perforation by bone cement after percutaneous kyphoplasty
Authors: kim Soon jin , kim kyung hwa 
Published: October 2020

Abstract
Background: Intracardiac cement embolisms(ICE) have been poorly reported in the literature. When the presence of intracardiac cement embolismsis identified, the cardiorespiratory complications related to ICE may be delayed and opinions also differ regarding whether the clinical consequences of this specific complication of percutaneous vertebroplasty (PV) is benign or malignant. Case presentation: A 63-year-old female patient was referred to our institution with chest discomfort and dyspnea. She had underwent PV in the lumbar vertebra one year ago. Radiologic investigations revealed the foreign material in the RA, perforating the RA wall and penetrating right pleura. We performed the removal surgically of the cement fragments after a median sternotomy with under heart-lung machine.Conclusions: when the presence of ICE is identified, the cardiorespiratory complications related to ICE may be delayed and a symptomatic and migrating bone cement must be considered surgical retrieval for the prevention of the progression into a constrictive pericarditis as well as symptom relief. This is the first report describing simultaneous cardiac and lung perforation and the longest interval period case (one year after PV) treated surgically caused by bone cement.
Deep Vein Thrombosis in the Uninjured Limbs of Lower Extremity Fractures: A Retrospective Study of 1454 Patients
Authors: Qu Shuang-Wei , Cong Yu-Xuan , Wang Peng-Fei , Fei Chen , Li Zhi , Yang Kun , Shang Kun , Ke Chao , Huang Hai , Zhuang Yan , Zhang Bin-Fei , Zhang Kun 
Published: October 2020

Abstract
Objective: The purpose of this study was to investigate the incidence of deep venous thrombosis (DVT) in the uninjured limb, before and after operation, in patients with lower extremity fractures.Methods: We collected the clinical data of patients with lower extremities fractures who presented at Xi’an Honghui Hospital between 1 July, 2015 and 31 October, 2017. Doppler ultrasonography was used to diagnose the DVT. Patients were examined pre- and postoperatively. The patients were then divided into a thrombosis group and a no thrombosis group according to the preoperative and postoperative ultrasonography results. The thrombosis group was defined as patients admitted to our hospital with DVT in the uninjured limb and the no thrombosis group was defined as patients without DVT in the uninjured limb. Results: This study enrolled 1454 patients who met the inclusion criteria. The incidence of preoperative DVT in the uninjured limb was 9.63% whereas the postoperative incidence was 20.29%. Age (OR=0.965, 95 CI%: 0.954 - 0.977; P≤0.001) and gender (OR=0.667, 95% CI: 0.451-0.986, P=0.042) were independent risk factors for preoperative DVT in the uninjured limb. Blood loss (OR=0.997, 95 CI%: 0.995-1.000; P=0.020), D-dimer levels at admission (OR=0.941, 95 CI%: 0.887-0.999; P=0.045), and postoperative day 5 D-dimer levels (OR=0.889, 95 CI%: 0.819-0.965; P=0.005), were independent risk factors for postoperative DVT in the uninjured limb.Conclusion: In conclusion, the actual incidence of DVT in the uninjured lower extremity after fracture may currently be underestimated and should be pay more attention.
Retrieving Similar Substructures on 3D Neuron Reconstructions
Authors: Yang Jian , He Yishan , Liu Xuefeng 
Published: October 2020

Abstract
An accurate neuron reconstruction is very important to understand neuron morphology and function, but it is still a challenging task due to the time consuming of manual tracing and the unsatisfactory accuracy of automatic tracing. One way to address the challenge is generating a reconstruction automatically and then checking and amending the result manually. Aiming at implementing this process efficiently, we propose a pipeline to retrieve substructures on one or more neuron reconstructions, which are very similar to a marked problematic substructure and need to be checked one by one. The pipeline consists of four steps: getting a marked substructure, constructing a query substructure, generating candidate substructures and retrieving most similar substructures. The retrieval procedure was tested on 163 gold standard reconstructions provided by the BigNeuron project and a reconstruction of a mouse’s large neuron. Experimental results showed that the implementation of the proposed methods is very efficient and all retrieved substructures are very similar to the marked one in numbers of nodes and branches, and degree of curvature.
A Prospective Study Investigating the Efficacy and Toxicity of Definitive ChemoRadadiation and ImmunOtherapy (CRIO) in Locally and/or Regionally Advanced Cutaneous Squamous Cell Carcinoma.
Authors: Lin Charles , Ballah Trishna , Nottage Michelle , Hay Karen , Chua Benjamin , Kenny Lizbeth , Thomas Paul , Teng Michele WL , Keller Jacqui , Le Trang , Edmunds Jennifer , Hughes Brett GM 
Published: October 2020

Abstract
Background: Patients with unresectable advanced cutaneous squamous cell carcinoma (cSCC) are generally treated with palliative intent. Immune checkpoint blockade has significant activity in the palliative setting in patients with recurrent or metastatic cSCC. This single arm phase 2 prospective study aims to investigate the combination of curative intent chemoradiation and durvalumab (anti-PD-L1 checkpoint inhibitor) for this patient cohort. Our hypothesis is that >70% of patients with locally-advanced primary disease or regional metastases can be safely treated for cure using ChemoRadiation and ImmunOtherapy (CRIO) compared to the null hypothesis of ≤50%. Methods: Patients with unresectable locally and or regionally advanced pathologically confirmed cSCC deemed suitable for CRIO by consensus of the Head and Neck Multidisciplinary meeting will be eligible. We aim to accrue a total of 15 patients. The co-primary endpoints of CRIO will be the safety of treatment and the complete response rate. Secondary endpoints will include overall survival, progression free survival, and locoregional control. Translational research endpoints including biomarkers will also be explored utilising multiplex immunohistochemistry on tumour biopsy samples obtained prior to commencing treatment and during treatment (week 2). In addition, the utility of CXCR-4 PET scan will be explored.Discussion: CRIO is a novel trial evaluating the combination of curative intent chemoradiotherapy with concurrent durvalumab for patients with inoperable locally advanced cSCC.Trial registration Trial registered with the Australian New Zealand Clinical Trial Registry (ACTRN12618001573246)