bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Measures during Construction of Ground Structures over Existing Underground Structures
Authors: Dalidovskaya A. A. , Pastushkov V. G. 
Published: October 2020

Today, there is an acute issue of ensuring the safe operation of buildings and structures located in the immediate vicinity of new construction. The process of performing works on the installation of load-bearing structures and their further operation can have a negative impact on already existing facilities. In this regard, the task of developing innovative methods and tools to ensure the safe operation of such structures as subway running tunnels is very urgent. To solve it, a reliable forecast of additional deformation and appointment of a complex of protective measures are required. In addition, much attention should be paid to the numerical modeling of the system “surface structures – protective measures – underground structures”. As an example of assessing the impact of new construction, namely, the erection of surface structures over existing underground ones, one can cite the construction of a transport interchange at the intersection of Nezavisimosty Avenue with Filimonov Street. As protective measures, a protective screen on bored piles has been used here, which made it possible to minimize significantly dynamic and static effects on the lining of tunnels and other underground structures of the subway. Effectiveness of protection application is confirmed by the result of monitoring the stress-strain state of running tunnel structures at all stages of traffic intersection construction. Protective measures and continuous monitoring of the stress-strain state in structures help to avoid accidents during construction and further operation.
Single-Level Station Complex Structure for Application of Through Driving Construction Method
Authors: Kolikov A. О. , Pastushkov G. P. 
Published: October 2020

Metro Service has a huge impact on the development of urban transport infrastructure. The need to increase the efficiency of passenger transportation is caused by the rapid growth in passenger turnover as well as an increase in the distance from the outskirts of the city to the center. In connection with the need to develop a metro service network in Minsk city, which is confirmed by research in the area of passenger traffic in the main areas of the city, the CSM Bessac tunnel boring machine was purchased, which allows significantly to increase the speed of tunnel driving. The use of a mechanized tunnel boring machine in the traditional concept of the metro network construction, in which driving of tunnels is carried out after construction of stations, does not allow to use a shield with maximum economic efficiency due to the small extent of tunnels. There is also a need to build assembly-shield chambers and carry out works on disassembling and assembling the shield. The application of the new concept developed by Yu. S. Frolov and called “through driving” is actual in the conditions of the use of a mechanized tunnel boring machine. Its essence lies in the continuous driving of tunnels on the line section under construction and the consecutive construction of each station complex as the tunnel boring machine passes through it. To implement the concept of “through driving”, it is relevant to use a semi-closed construction method, in which the floor structure is constructed in an open way, and the other elements are closed. The available solutions of the metro stations constructed while using a semi-closed method of work have been analyzed in the paper. A detailed analysis has been carried out with due account of the adaptation to the construction conditions in Minsk, and the development of structural elements and assemblies of the platform area of the station, which is a two-cantilever vault with a developed transom part, resting on pile-columns of a circular cross section. Forces from the open ring of flexible tunnels lining are supported by a cantilever part of an arch and a bottom plate. The paper considers a design of a metro station, its main elements, their purpose and specificity of work, as well as optimization issues and the results of the design feasibility study.
Development of Real-time Monitoring System in Organic Rankine Cycle Operation of Lahendong Geothermal Field
Authors: Wibowo Satriyo Nurhanudin , Aji Prasetyo , Cahyadi Cahyadi , Suyanto Suyanto , Pudyastuti Kris , Akbar Muhammad Nur 
Published: October 2020

Abstract
Geothermal resources in Indonesia are commonly located in spread mountain area and some scattered in small islands, such as in Nusa Tenggara and Maluku province. Small scale geothermal power plant with a wellhead type may be required for some geothermal field areas. In operation and maintenance of geothermal power plant usually need high skilled personnel. The real-time monitoring system (RTMS) becomes a promising option for performance analysis and optimization from a remote monitoring room. The performance engineer may execute some small scale power plant in different project sites. The monitoring needs the data variables related significantly to the production of power output. Therefore, finding an attractive-interface, and related variables data of power output, become an interesting issue in performance monitoring.
Lahendong organic Rankine cycle (ORC) power plant in North Sulawesi Indonesia, with a capacity of 500 kW, has implemented the RTMS. RTMS data, starting from the sensor reading up to the programmable logic controller (PLC) as a local data collector, transferred to the server (which placed in Germany) via the connection hub. From the server, the data stored on the database and visualize on the human-machine interface (HMI). The variables of the RMTS have been analyzed. The study includes analyzing the scatter-plot of the variables, plotting of the time variables, and applied the Pearson coefficient correlation (PCC) to discover the most related variables to the power output. The variables include brine inlet temperature, brine inlet pressure, hot water inlet temperature, hot water inlet pressure, and power output during the three months.
The result, the monitoring of the Lahendong ORC power plant gives positive feedback to the user, with interactive visualization data. The feedback shows that hot water temperature has the most robust correlation to the power output of the Lahendong ORC power plant with 0.91, close to 1 for PCC analysis.
In the future, machine learning analysis will be applied to RTMS on Lahendong, so that it will increase user experience and sharpening data analysis. The relocation of the server from Germany to Indonesia will be done to add decision-making features.
Expectedly, this paper can be a reference to other power plants and fields that apply RTMS as remote monitoring, taking into consideration the remote location of the geothermal field.
Anxiety, Perceived Stress And Coping Strategies In Nursing Students: A Cross-sectional, Correlational, Descriptive Study
Authors: Onieva-Zafra María Dolores , Fernández-Muñoz Juan José , Fernández-Martínez Elia , García-Sánchez Francisco José , Abreu-Sánchez Ana , Parra-Fernández María Laura 
Published: October 2020

Abstract
Background: For many nursing students, clinical training represents a stressful experience. The levels of stress and anxiety may vary during students’ educational training, depending on their ability to adopt behavioral strategies for coping with stress, and other factors. This study aimed to investigate the relationship between anxiety, perceived stress, and the coping strategies used by nursing students during their clinical training.
Methods: A cross-sectional correlational descriptive study. The sample consisted of 190 nursing students enrolled in the Nursing Faculty of Ciudad Real University in Spain. Participants provided data on background characteristics and completed the following instruments: the Perceived Stress Scale; the State-Trait Anxiety Inventory and the Coping Behavior Inventory. Relationships between scores were examined using Spearman’s rho.
Results: The mean age of participants was 20.71± 3.89 years (range 18-46 years). Approximately half of the students (47.92%) indicated a moderate level of stress with a mean Perceived Stress Scale score of 22.78 (±8.54). Senior nursing students perceived higher levels of stress than novice students. The results showed a significant correlation for perceived stress and state anxiety (r= 0.463, p<.000) and also for trait anxiety (r=0.718, p<.000). There was also a significant relationship between the total amount of perceived stress and the following domains of the coping behavior inventory: problem solving (r =-.452, p<.01), self-criticism (r =.408 p<.01), wishful thinking (r =.459, p<.01), social support(r =-.220, p<.01), cognitive restructuring (r =-.375, p<.01), and social withdrawal (r =.388, p<.01). In the current study, the coping strategy most frequently used by students was problem-solving, followed by social support and cognitive restructuring.
Conclusions: Nursing students in our study presented a moderate level of stress, in addition there was a significant correlation with anxiety. Nursing teachers and clinical preceptors/mentors should be encouraged to develop programs to help prepare nursing students to cope with the challenges they are about to face during their clinical placements.
Interaction Kinetics of Peptide Lipids-Mediated Gene Delivery
Authors: Zhao Yinan , Zhao Tianyi , Du Yanyan , Cao Yingnan , Xuan Yang , Chen Huiying , Zhi Defu , Guo Shutao , Zhong Fangli , Zhang Shubiao 
Published: October 2020

Abstract
Background: During the course of gene transfection, the interaction kinetics between liposomes and DNA is speculated to play very important role for blood stability, cellular uptake, DNA release and finally transfection efficiency. Results: As cationic peptide liposomes exhibited great gene transfer activities both in vitro and in vivo, two peptide lipids, containing a tri-ornithine head (LOrn3) and a mono-ornithine head (LOrn1), were chosen to further clarify the process of liposome-mediated gene delivery in this study. The results show that the electrostatically-driven binding between DNA and liposomes reached nearly 100% at equilibrium, and high affinity of LOrn3 to DNA led to fast binding rate between them. The binding process between LOrn3 and DNA conformed to the kinetics equation: y = 1.663631 × exp(-0.003427x) + 6.278163. Compared to liposome LOrn1, the liposome LOrn3/DNA lipoplex exhibited a faster and more uniform uptake in HeLa cells, as LOrn3 with a tri-ornithine peptide headgroup had a stronger interaction with the negatively charged cell membrane than LOrn1. The efficient endosomal escape of DNA from LOrn3 lipoplex was facilitated by the acidity in late endosomes, resulting in broken carbamate bonds, as well as the“proton sponge effect”of the lipid. Conclusions: The interaction kinetics is a key factor for DNA transfection efficiency. This work provided insights into peptide lipid-mediated DNA delivery that could guide the development of the next generation of delivery systems for gene therapeutics.
Magnitude of Turnover Intention and Associated Factors Among Nurses Working in Emergency Departments of Governmental Hospitals in Addis Ababa, Ethiopia: A cross sectional institutional based study.
Authors: Aniley Andualem Wubetie , Taye Biniyam , Girma Biruk 
Published: October 2020

Abstract
Background: Turnover intention is a probability of an employee to leave the current institution within a certain period due to various factors. It is the strongest predictor of actual turnover expected to increase as the intention increases. Emergency Department (ED) nurses are especially vulnerable to high turnover because of their increased risk of developing burnout and compassion fatigue associated with the work environment. This study is aimed to assess nurses’ intention to leave emergency departments and associated factors at selected governmental hospitals in Addis Ababa, Ethiopia.Methods: Institutional based cross-sectional study was conducted on 102 nurses in three selected governmental hospitals, Addis Ababa from February 19 to March 31, 2018, using a structured pre-tested self-administered questionnaire. The logistic regression model was used and an adjusted odds ratio with a 95% confidence interval was calculated to identify associated factors.Result: A total of 102 respondents were involved with a response rate of 91.1%. Among them, 79 (77.5%) respondents had the intention to leave the current working unit of the emergency department or hospital. Significant predictive factors of nurses' intention to leave their institutions are educational status (adjusted odds ratio (OR) =4.700, 95% confidence interval (CI)=1.033- 50.772; p<0.048), monthly income of less than 3145 Birr (adjusted OR=6.05, 95% CI=1.056-34.641; p<0.043) and professional autonomy (adjusted OR=0.191, 95% CI=0.040- 0.908; p<0.037).Conclusion: More than 77% of the respondents have the intention to leave their current working place of the emergency unit. Educational status, monthly income, and autonomy were significantly associated with emergency nurses’ turnover intention in three governmental hospitals. Emergency leaders and hospital managers should have made efforts to enhance nurses' decision making for patient care activities and shared decision overwork or unit related activities.
Differentiation protocol for cranial neural crest-derived pericyte-like cells from human pluripotent stem cells
Authors: Sun Jiaqi , Huang Yinong , Gong Jin , Wei Yili , Xiong Chuanfeng , Xiang Andy Peng , Li Weiqiang 
Published: October 2020

Abstract
The successful differentiation of brain pericyte-like cells from human pluripotent stem cells may allow us to study their biological characteristics and their applications in the treatment of pericyte dysfunction-related neurodegenerative diseases, including ischemic stroke, Parkinson’s disease (PD) and so on.The protocol we present in the study provides a cranial neural crest originated, fast and robust forebrain pericyte-like cells differentiation method using either human embryonic stem cells or human induced pluripotent stem cells as a starting material.
Inhibitory Effects of the Spore-forming Bacillus spp. on the Expression Levels of eae, luxS, flu, and ctxM Genes in E. coli Isolates
Authors: Elahianfiroz Zahra , baserisalehi majid , Ghane masood 
Published: October 2020

Abstract
Background Escherichia coli antibiotic resistance is one of the major health problems in many countries. Nowadays, researchers are focusing on novel approaches for the treatment of E. coli infections, including the use of spore-forming probiotics for their high stability in the harsh gastrointestinal (GIT) environment.MethodsInitially, 300 stool samples were collected from patients with gastrointestinal infections admitted to Imam Khomeini Hospital in Tehran. Then, diagnostic tests were performed to detect E. coli isolates on the samples. A DNA test was applied to examine the presence of ctxM, luxS, eae and flu in the samples. Afterward, the effect of native and commercial probiotics of Bacillus subtilis and Bacillus coagulant was investigated on the expression of the studied genes. ResultsGenes of flu, eae, luxS, and ctxM which are involved in bacterial attachment, biofilm formation, signaling, and antimicrobial resistance were existing in four out of 40 E. coli isolated among patients suffering from diarrhea. The expression levels of flu, luxS, eae, and ctxM genes decreased significantly (p-value < 0.05) after co-culture of E. coli with B. subtilis ATCC 6633 and broiler-derived B. subtilis. Both broiler-derived B. subtilis and broiler-derived B. coagulans have a significant effect on all the studied genes.Conclusions The broiler-derived isolates had a greater capacity to decrease the expression of these genes than the standard strains, proposing their adoption for dietary supplementations.
A&nbsp;Modified Posterolateral Approach&nbsp;for the Treatment of Posterior Malleolar&nbsp;Fracture
Authors: Wenlai Fang , jianzhong Kong , mochuan Chen 
Published: October 2020

Abstract
Background: To observe the clinical effect of a modified posterolateral approach internal fixation in the treatment of posterior malleolar fracture. Method: From January 2015 to October 2018, 30 cases involving lateral and posterior malleolar fracture patient data were treated in our department. we observed operation time, fracture healing time and postoperative complications. At the time of the last follow-up, we evaluated ankle joint function by the American Orthopedic Foot Ankle Society (AOFAS) ankle- hindfoot scale, the Short Form-36 (SF-36) outcome Tools and the American Academy of Orthopaedic Surgeons (AAOS) Foot and Ankle Questionnaire. Result: In this group of 30 patients, the operation time of the patients was 80-120min (median 90min). The 25 patients were followed up for more than 1 year. 3 ~ 5 months after the operation, all the patients had bony healing. 3 cases with superficial wound infection. No other complication was found. The mean AOFAS scores at the postoperative 6-month, 12-month, and final follow-up were 78.4 (range, 72–90), 89.4 (range, 80–96), and 90.8 (range, 84–96), respectively. The mean SF-36 scores at the postoperative 12-month and final follow-up were 82.4 (range, 77.6–90.6) and 84.6 (range, 77.8–92.6), the mean AAOS scores at the postoperative 12-month and final follow-up were87.8 (range, 79–95), 90.6 (range, 82–96). Conclusion: Modified posterolateral approach avoided stripping the muscular origins of flexor hallucis longus, reduced the adhesion, and can fix the lateral and posterior malleolar fracture in the same incision, is worth popularizing in clinical.
Fitbit data show poor correlation with measures of activity and sleep among hospitalized general medicine patients
Authors: Wu Robert Clark , Patel Vikas , Moosa Sabreena , Langer Laura , MacMillan Thomas E. , Cavalcanti Rodrigo B. , Cram Peter , Gunaratne Keith , Bayley Mark 
Published: October 2020

Abstract
Background: Wearable devices such as Fitbits may provide important insights about hospitalized patients that include data on low activity and poor sleep. Monitoring this information could spur interventions to improve mobility and sleep which may reduce the adverse effects associated with hospitalization. However, there is a lack of studies assessing the accuracy of wearables in hospitalized medical patients. The purpose of our study was to determine the accuracy of Fitbit heart rate, sleep and physical activity in hospitalized medical patients.Methods: We conducted a prospective cohort feasibility study enrolling 50 medical inpatients at two hospitals providing them with a wrist-worn Fitbit Charge. Our main measures were Fitbit heart rate, sleep and activity data as well as nurse recorded heart rates, patient reported sleep, and nurse assessments of activity.Results: Of the 50 patients who consented to the study, 47 patients wore the devices. Comparing pairs of heart rate data from Fitbit and nurse recorded vital signs for the same minute, there were 261 pairs available for comparison. The mean difference was 0.45 bpm (SD: 13.0, Pearson correlation: 0.68 P<0.001) and the 95% limits of agreement were -25 to 26 bpm. The association between the patient-reported sleep score and Fitbit total sleep duration was 0.19 (P=0.24) and between the self-reported hours of sleep and Fitbit total sleep duration was 0.21 (P=0.21). The correlation between nurse-recorded activity and Fitbit daily steps was 0.06 (P=0.52). Conclusions: Fitbit heart rates correlated well with nurse-recorded heart rate but did not correlate well with nurse assessments of activity nor with patient self-assessment of sleep. This study highlights limitations of the accuracy of current wearable wrist-worn device algorithms in activity and sleep detection in patients in hospital. The findings call into question the validity of Fitbits for assessment of patient activity and sleep in the hospital setting and suggest that they should not be routinely used without further validation.Trial Registration: ClinicalTrials.gov NCT03646435
Assessment of HIV Related Disabilities among People Living with HIV Who Are on ART. A Cross Sectional Survey in Blantyre Urban, Malawi
Authors: Manyozo Steven Derrick , Nesto Tarimo , Kawalazira Gift , Muula Adamson Sinjani 
Published: October 2020

Abstract
Background Despite improvements in survival, persons living with HIV experience a range of physical, cognitive, mental and social health-related challenges. Among adult persons living with HIV in Malawi, the prevalence of disability and associated risk factors are not known. This study was designed to assess the prevalence of impairments, activity limitations and associated risk factors among adults living with HIV in Blantyre urban, Malawi. MethodsWe conducted a quantitative cross-sectional study among adult persons aged 18 years and older living with HIV and on ART receiving their care at five government run health facilities in Blantyre urban. We used the WHO’s International Classification of Functioning, Disability and Health (ICF) for data collection. The ICF provides a unified, standard language and framework for the description of health and health-related states. The College of Medicine Research Ethics Committee (COMREC) approved the study and written informed consent was obtained from study participants. Descriptive statistics were used to summarize the data. Univariable and multivariable logistic regression were used to assess association between presence of disability and selected factors. Odds ratios (OR) and their 95% confidence intervals were calculated.Results Of the 277 participants enrolled, 225 (81%) were female and 52 (19%) were male. The mean age of participants was 37 years (std. dev 9.5). Impairments in mental functions (43%) and sensory functions and pain (40%) were the most prevalent among the study participants. Energy and drive (18%), memory (14%) and sleep (13%) were the most affected mental functions. Socio-demographic characteristics were not significantly associated with occurrence of the mental function impairments. Conclusions Our study highlights the level of impairments among person living with HIV especially mental health impairments, sensory functions and pain. Integrated health services including mental health screening and care, physical rehabilitation into all HIV testing and treatment settings are very critical to improve service delivery but also general access to rehabilitation by persons living with HIV.