Abstract PO-169: Racial distribution of neighborhood social deprivation in a retrospective cohort of prostate cancer survivors
Authors: Babatunde Oluwole Adeyemi , Pearce John , Jefferson Melanie , Frey Lewis , Angel Peggi , Drake Rick , Allen Caitlin , Halbert Chanita Hughes- 
Published: December 2020

Abstract
Background: Cancer incidence and mortality rates vary across geographic areas; however, a better understanding of neighborhood level variables is needed to increase the precision of cancer control interventions that target geographic determinants of cancer health disparities. The purpose of this study is to characterize the distribution of neighborhood deprivation features in a cohort of racially diverse prostate cancer survivors based on social determinants (e.g., race) and clinical characteristics (e.g., Gleason score, tumor stage). Methods: A retrospective cohort of prostate cancer patients who were treated with radical prostatectomy from 2011 to 2019 was established using the tumor registry at the Hollings Cancer Center at the Medical University of South Carolina. Data on clinical variables (e.g., stage, grade) and social determinants (e.g., race) were abstracted from electronic medical records. Residential addresses were geocoded and neighborhood-level social deprivation measures (income, education, employment, housing, household characteristics, transportation and demographics) from the 2011-2015 American Community Survey five-year estimates were used to generate a composite Social Deprivation Index (SDI) using factor analysis. Next, descriptive, bivariate and correlation analyses were conducted to characterize SDI and examine the association between social determinants, clinical characteristics, and SDI. Results: The study sample included 249 men (168 white men and 81 African American men) who had an average age of 66 years (+6.6). The mean for SDI was 44.5 (+27.4) and the range was 97 (1-98).
White men that were married were 88.7% while African American men that were married were 77.8% (p: 0.02). Men who lived in neighborhoods that had a high level of social deprivation (i.e., SDI score of 48 to 98) were 121 (48.6%). There were significant racial differences in SDI between African American and white men. The mean SDI score was 58.5 (+26.9) among African American men compared to 37.8 (+25.0) among white men (p&lt;0.01). In the logistic regression model, African American men had a significantly greater likelihood of living in a socially deprived neighborhood compared to white men (OR=4.2, 95% C.I. 2.4-7.5, p&lt;0.01). In addition, men between the ages of 47-67 years were significantly more likely than men ages 68-80 to in a deprived neighborhood (OR=1.8, 95% C.I.=1.1-3.0, p- value=0.02). None of the clinical characteristics were associated significantly with SDI. Conclusion: This study demonstrates that SDI varies considerably among men. Greater efforts may be needed to address neighborhood level factors among African American men who have a personal history of prostate cancer.
Citation Format: Oluwole Adeyemi Babatunde, John Pearce, Melanie Jefferson, Lewis Frey, Peggi Angel, Rick Drake, Caitlin Allen, Chanita Hughes- Halbert. Racial distribution of neighborhood social deprivation in a retrospective cohort of prostate cancer survivors [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-169.