bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-ResNeXt for epilepsy recognition based on EEG signals in wireless networks
Authors: wang shaoqiang , wang shudong , Zhang song , wang yifan 
Published: February 2020

Abstract
To automatically detect dynamic EEG signals to reduce the time cost of epilepsy diagnosis. In the signal recognition of electroencephalogram (EEG)of epilepsy, traditional machine learning and statistical methods require manual feature labeling engineering in order to show excellent results on a single data set. And the artificially selected features may carry a bias, and cannot guarantee the validity and expansibility in real-world data. In practical applications, deep learning methods can release people from feature engineering to a certain extent. As long as the focus is on the expansion of data quality and quantity, the algorithm model can learn automatically to get better improvements. In addition, the deep learning method can also extract many features that are difficult for humans to perceive, thereby making the algorithm more robust. Based on the design idea of ​​ResNeXt deep neural network, this paper designs a Time-ResNeXt network structure suitable for time series EEG epilepsy detection to identify EEG signals. The accuracy rate of Time-ResNeXt in the detection of EEG epilepsy can reach 91.50%. The Time-ResNeXt network structure produces extremely advanced performance on the benchmark dataset (Berne-Barcelona dataset), and has great potential for improving clinical practice.
The Association Between Gallstone Disease and Metabolic Syndrome Related Abnormalities: A Systematic Review and Meta-Analysis
Authors: Jiang Peiwu , Ni Zhongkai , Huang Shifei , Li Xiaowen , Li Ye , Huang Hai 
Published: February 2020

Abstract
BackgroundBile excretion is one of an important metabolite excretion pathway of human body. In recent years, it has been reported that metabolic diseases are associated with the occurrence of GSD (Gallstone Disease). The main purpose of this systematic review is to examine the relationship between metabolic syndrome and cholelithiasis, including components of the metabolic syndrome such as abnormal blood glucose regulation, hyperlipidemia, and obesity.MethodsPubmed, Cochrane library and embase were searched for all English language articles for the following relevant keywords: Metabolic Syndrome, Reaven Syndrome X, Biliary Calculi, Cholelithiasis Gallstones. Case-control study, cross-sectional study and cohort study were included .Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The pooled mean differences of the outcome measures were compared between patients with and without MetS.ResultsAfter screening, a total of 5 cross-sectional studies and 1 cohort studies were included in the meta-analysis. The 6 studies evaluated a total of 49101 people，of whom 9055 had MS and 2308 had GSD. There is a significant correlation between MS and GSD (z=6.65, p = 0.000), and it’s more significant in female. All studies displayed increasing odds of GSD with increasing number of MetS traits, where patients with three or more MetS traits tended to have a higher prevalence of nephrolithiasis.ConclusionsOur review shows a definite association of MetS with GSD, and the more the components of MetS, the higher the prevalence of GSD. Although not as obvious as women, men also support this conclusion.
The association between eating rate and functional dyspepsia in Iranian adults
Authors: Saneei Parvane , Keshteli Ammar Hassanzadeh , Rasad Hamid , Daghaghzadeh Hamed , Feizi Awat , Esmaillzadeh Ahmad , Adibi Peyman 
Published: February 2020

Abstract
Objective: This study aimed to investigate the association between eating rate and functional dyspepsia (FD) in a large population of Iranian adults.Methods: In this cross-sectional study, we assessed eating rate of 4763 Iranian adults using a dietary habit questionnaire. We used a modified validated version of the Rome III questionnaire to assess gastrointestinal health. FD was defined as having one or more of the following characteristics: bothersome postprandial fullness, early satiation and/or epigastric pain or epigastric burning. Needed information on meal frequency, meal regularity, intra-meal fluid drinking as well as on other potential confounders was obtained by using a pre-tested questionnaire.Results: Functional dyspepsia was prevalent in 15.2% (n=703) of the studied population. Lunch and total eating rate was associated with greater odds of having FD(OR: 1.37; 95% CI: 1.04-1.8) and (OR: 1.45; 95% CI: 1-2.11), respectively). However, this relationship weakened after adjusting for confounding factors. No significant relationship was found between dinner eating rate and FD in both crude and adjusted models (OR: 1.23; 95% CI: 0.83-1.51). There was no significant relation between lunch, dinner or total eating rate and risk of postprandial fullness, early satiation or epigastric pain either in crude or adjusted models. Eating rate was not related to severity or frequency of FD components.Conclusions: Fast eating was associated with greater odds of FD. However, there was no association between fast eating with postprandial fullness and epigastria pain. Further studies, particularly prospective ones, are required to confirm these relations.
Molecular detection of genotypes and subtypes of Cryptosporidium infection in diarrheic calves, lambs, and goat kids from Turkey
Authors: Kabir Mohammad Hazzaz Bin , Ceylan Onur , Ceylan Ceylan , Shehata Ayman Ahmed , Bando Hironori , Essa Mohamed Ibrahim , Xuan Xuenan , Sevinc Ferda , Kato Kentaro 
Published: February 2020

Abstract
Background: Cryptosporidium spp. are enteric protozoan parasites that infect a wide range of animals as well as humans. The studies on Cryptosporidium infections of animals in Turkey are mostly rely on microscopic observation. Few data are available regarding the distribution of Cryptosporidium genotypes and subtypes infection. The aim of this study is to analyse the zoonotic potential of Cryptosporidium oocysts shed from young ruminant livestock. Methods: A total of 415 diarrheic fecal specimens from 333 calves, 67 lambs, and 15 goat kids were examined for the presence of Cryptosporidium oocysts by microscopy. Microscopic positive specimens were then analyzed for Cryptosporidium genotypes and subtypes detection by use of nested PCR of the small subunit ribosomal RNA (SSU rRNA) gene and the highly polymorphic 60 kDa glycoprotein (gp60) gene followed by sequence analyses. Results: The results of this study revealed that 25.6% (106 of 415) of the specimens were positive for Cryptosporidium spp. infection by microscopic examination and molecular analysis. We identified 27.4% (91/333), 19.4% (13/67), and 13.4% (2/15) of positivity in calves, lambs and goat kids, respectively. Genotyping of the SSU rRNA indicated that almost all positive specimens were of C . parvum , except for one calf which was of C. bovis . Sequence analysis of the gp60 gene revealed the most common zoonotic subtypes (IIa and IId) of C . parvum. We detected 11 subtypes (IIaA11G2R1, IIaA11G3R1, IIaA12G3R1, IIaA13G2R1, IIaA13G4R1, IIaA14G1R1, IIaA14G3R1, IIaA15G2R1, IIdA16G1, IIdA18G1, IIdA22G1); three of them (IIaA12G3R1, IIaA11G3R1 and IIaA13G4R1) was novel subtypes found in calves and lambs. Additionally, three subtypes (IIaA11G2R1, IIaA14G3R1, and IIdA16G1) were detected in calves, lambs, and goat kid for the first time in Turkey. Conclusions: The findings illustrate the high occurrence of Cryptosporidium infection in Turkey and suggest that calves, lambs, and goat kids are likely a major reservoir of C. parvum and a potential source of zoonotic transmission, which may have public health implications. Keywords: Calves, C. bovis, C. parvum , Cryptosporidium , Diarrhea, Goat kids, Lambs, Subtypes, Turkey.
Lived experience of intimate partner violence among women using antiretroviral therapy and other outpatient services in Wolaita Zone, Ethiopia: A phenomenological study
Authors: Meskele Mengistu , Khuzwayo Nelisiwe , Taylor Myra 
Published: February 2020

Abstract
Background Ethiopia is one of the nations which has an enormous burden of intimate partner violence (IPV), and where it is usually difficult to talk about HIV separately from IPV.Objectives This research aimed to explore the lived experience of IPV against women using antiretroviral therapy (ART) and other outpatient services in Wolaita Zone, EthiopiaMethods We used an Interpretive (hermeneutic) Phenomenological Analysis design among purposely selected adult women aged 18-49 years. A total of 43 women involved in this study, of whom 30 were using ART, and 13 women were using other health services. We used an in-depth interview and focus group discussions until data saturation, while conscious of the need to maintain the scientific rigor, dependability, and credibility relating to this sensitive subject. The data were transcribed verbatim and translated into English. We read the transcripts repeatedly to understand the content. We used NVivo 11 software to assist with data organization, and also we used the framework analysis method.Results We identified five themes from this analysis, namely: “women's terrifying experiences of violence,” “the effects of violence on their health,” “support/lack of support /partner’s controlling behaviors,” “women’s feelings about the available services,” and “IPV prevention strategies from the perspective of women.” Interviewees described their violent experiences which included wife-beating, being stigmatized in front of others, having material thrown at the woman’s face, wife’s hand and teeth were broken, forced sex, restriction of movement, name-calling, threats to hurt, being insulted, being left alone, and the withdrawal of finances. The negative health impacts reported included abortion, infection with HIV and other sexually transmitted diseases, discrimination, disability, fear, divorce, child’s death, and depression. The disclosure of HIV test information resulted in violence. Inappropriate punishment of the perpetrator and the lack of a supportive women’s network to avert IPV were perceived as legal limitations by the women.Conclusions IPV is a considerable health burden, varying in its presentation and its negative impact on women’s health and well being. Improved laws should provide justice for all victims. Establishing a women’s network to assist should be emphasized. Unwise HIV test result disclosure leads to IPV; hence HIV disclosure should be facilitated through health care providers.
PI3K inhibitor significantly enhances the antitumor activity of oncolytic virus in osteosarcoma
Authors: Wang Ye , Yang Xin , Li Hong , Xie Haiyang 
Published: February 2020

Abstract
Background: Osteosarcoma (OS) is a highly aggressive malignancy with less than 30% 5-year survival rate among patients with metastatic or recurrent cancer. However, the treatment for osteosarcoma has not been modified in the last three decades. Oncolytic viruses have shown encouraging results in pre-clinical trials, but have failed to translate into high therapeutic efficacy in clinical trials. In this study, we will determine the therapeutic effect of combining PI3K inhibitor with an oncolytic virus against osteosarcoma. Material and Methods: Osteosarcoma cell lines and xenograft model were treated with ZSTK474 and/or VSVΔ51, the tumor suppressive ability was verified by in vitro cytotoxicity experiments and in vivo antitumor activity experiments, and the antitumor mechanism was explored through the study of apoptosis-related signaling pathways. Results: ZSTK474 sensitized the osteosarcoma cells to VSVΔ51, and augmented apoptosis via endoplasmic reticulum stress. The combination treatment also showed greater in vivo tumor inhibition compared to either ZSTK474 or VSVΔ51 alone, and significantly enhanced the tumor infiltration of immune cells. Conclusion: PI3K inhibitors combined with oncolytic virus is a promising strategy against osteosarcoma.
Lifestyles associated with prognosis after eradication of hepatitis C virus: a prospective cohort study in Japan
Authors: Ohfuji Satoko , Matsuura Tomoka , Tamori Akihiro , Kubo Shoji , Sasaki Satoshi , Kondo Kyoko , Ito Kazuya , Fukushima Wakaba 
Published: February 2020

Abstract
Background Hepatocellular carcinoma develops in some patients with hepatitis C virus (HCV), even after achieving sustained virological response (SVR). This prospective cohort study of SVR patients examined factors associated with liver disease progression. Methods Participants were patients who had visited a hospital for clinical follow-up of chronic HCV infection in 2005 and had reached SVR as a result of subsequent antiviral treatment. Baseline information including lifestyle and dietary habits before SVR were collected in 2005 using self-administered questionnaires, and clinical information before SVR was collected from medical records in 2005. Study outcome was liver disease progression such as liver cirrhosis, hepatocellular carcinoma, and/or liver disease-related death after SVR. Logistic regression models were employed to calculate odds ratios (ORs) and 95% confidence intervals for each variable. Results Of 180 SVR patients, 27 patients (15%) showed liver disease progression after SVR: 26 (14%) were diagnosed with liver cirrhosis, two (1%) with hepatocellular carcinoma, and/or one (0.6%) with liver-disease related death. Besides older age at SVR (OR=6.65, P=0.01) and aspartate aminotransferase-to-platelet ratio index score ≥ 1.0 before SVR (OR=5.22, P<0.01), alcohol drinkers before SVR (OR=2.83, P=0.09) appeared to be associated with liver disease progression after SVR, whereas higher consumption of vitamin B12 before SVR showed a decreased OR for liver disease progression (OR=0.35, P=0.09). Conclusions Alcohol drinking was associated with liver disease progression, whereas vitamin B12 intake had protective effects for liver disease progression after eradication of HCV. Further studies are needed to confirm these findings.
Bibliotecários de Arte no Brasil formação e desenvolvimento profissional: um estudo exploratório
Authors: Lima Vânia Mara Alves 
Published: February 2020

Apresenta um estudo exploratório sobre a formação e o desenvolvimento profissional dos bibliotecários de arte no Brasil. Contextualiza essa questão com breve histórico da criação dos cursos de Biblioteconomia no país. Analisa o oferecimento ou não de disciplinas relacionadas às Artes nas estruturas curriculares dos cursos atuais. Aplica um questionário aos bibliotecários que atuam nas instituições que que integram a Rede de bibliotecas e Centros de Informação em Arte - REDARTE em São Paulo e no Rio de Janeiro, com o intuito de coletar dados sobre a formação, identificar os caminhos percorridos para sua formação na área além de procurar ouvir desses profissionais, quais conhecimentos habilidades e competências eles consideram necessários para promover seu desenvolvimento profissional no campo da informação e documentação em Arte.
Desmistificando os princípios FAIR: conceitos, métricas, tecnologias e aplicações inseridas no ecossistema dos dados FAIR
Authors: Henning Patricia Corrêa , Ribeiro Claudio Jose Silva , Sales Luana Farias , Moreira Luiz Rebelo , Santos Luiz Olavo Bonino da Silva 
Published: February 2020

Os princípios FAIR, um acrônimo para Findable, Accessible, Interoperable e Reusable, estão presentes nas discussões e práticas contemporâneas da ciência de dados, desde o início de 2014, e tiveram sua aplicação consolidada em 2017, quando a Comissão Europeia passou a exigir a adoção de plano de gestão de dados, com base nesses princípios, por projetos financiados por seus recursos. Desde então, tais princípios passaram a ser norteadores da descoberta, do acesso, da interoperabilidade, do compartilhamento e da reutilização dos dados de pesquisa. No entanto, quando colocados em prática levantam dúvidas e imprecisões, gerando diferentes interpretações, o que dificulta sua aplicação. Por essa razão buscou-se elucidar seu entendimento, utilizando-se de conceitos esclarecedores, apresentando métricas específicas que medem o nível de FAIRnessdos objetos digitais; disseminando a proposta do ecossistema dos dados FAIR e as tecnologias Data FAIRPort e FAIR Data Point. Apresentamos, ainda, estudos realizados na Europa que comprovam o impacto e o potencial desses princípios, em diferentes áreas disciplinares, dando destaque às necessidades e aos exemplos de aplicação. A abordagem metodológica desta pesquisa é de natureza bibliográfica e de caráter qualitativo dando ênfase na descrição conceitual dos elementos necessários para a compreensão do ecossistema FAIR, o que permitiu, neste estudo, trabalhar a fundamentação teórica e conceitual, bem como o uso das práticas do FAIR em diferentes contextos e dimensões. As considerações finais corroboram as mudanças culturais e tecnológicas que vêm ocorrendo, no mundo informacional, relacionadas às novas práticas de gestão de dados e às interações e parcerias necessárias para a sua complexaimplementação.
Pemanfaatan Manggis Sebagai Sediaan Antiseptik dalam Upaya Peningkatan Kesehatan Masyarakat di Desa Sayang, Jatinangor, Sumedang
Authors: Wathoni Nasrul , Putri Norisca Aliza , Cahyanto Arief , Muchtaridi Muchtaridi 
Published: February 2020

Kuliah Kerja Nyata Mahasiswa (KKNM) merupakan suatu bentuk pengabdian mahasiswa kepada masyarakat, yang mana mahasiswa mengaplikasikan apa yang sudah diterima selama perkuliahan. KKN periode Juni 2019 bersifat terpadu dengan kegiatan Riset dan Pengabdian Pada Masyarakat (PPM) Dosen. Topik KKN-PPM yang didapat adalah ‘Pemanfaatan Manggis sebagai Sediaan Antiseptik dalam Upaya Peningkatan Kesehatan Masyarakat’. Program kerja ini dilaksanakan di Desa Sayang, Kecamatan Jatinangor, Kabupaten Sumedang. Manggis memiliki banyak manfaat bagi kesehatan, salah satunya kandungan Xanthone pada kulit manggis yang berfungsi sebagai antiseptik yang menjadi fokus program kerja KKN-PPM ini. Kulit manggis diolah menjadi produk antiseptik yang dapat digunakan secara praktis oleh masyarakat. Produk olahan dari kulit manggis berupa Sabun Cair Antiseptik dan Gel Antiseptik. Setelah kegiatan KKN-PPM ini berakhir, pengetahuan masyarakat tentang pengolahan buah atau tumbuhan sebagai produk yang bermanfaat bagi kebersihan dan kesehatan, khususnya buah manggis, diharapkan dapat bertambah.setelah dilakukannya penyuluhan mengenai betapa pentingnya menjaga kesehatan terutama pada hal mencuci tangan dengan benar maka dengan begitu tingkat kesehatan masyarakat akan meningkat seiring dengan peningkatan kesejahteraan ekonomi masyarakat. Dari kegiatan KKN Desa Sayang 2019 yang telah dilaksanakan ini, diharapkan masyarakat di Desa Sayang mampu memanfaatkan hasil perkebunan untuk diubah menjadi suatu produk yang mempunyai nilai lebih seperti gel antiseptik yang berbahan dasar kulit manggis yang banyak mengandung komponen bahan aktif Xanthone. Kulit manggis yang mengandung Xanthone tersebut dapat diolah menjadi sediaan antiseptik seperti sabun cair antiseptik dan gel antiseptik. Setalah dilakukan penyuluhan tentang manfaat buah manggis kami mendapati bahwa pengetahuan masyarakat tentang manggis meningkat, khususnya pada pengetahuan tentang manfaat buah manggis yang saat pre-test sebanyak 76.92% menjawab benar kemudian saat post-test meningkat menjadi 84.61%. Berdasarkan pre-test dan post-test yang kami lakukan juga dapat disimpulkan pengetahuan masyarakat tentang buah manggis dapat diolah menjadi produk antiseptic juga meningkat, dimana saat pre-test 76.92% menjawab benar dan setelah post-test 100% menjawab benar. Kemudian setelah dilakukan praktek langsung membuat gel antiseptic bersama masyarakat, berdasarkan post-test kami mendapati bahwa 46.15% masyarakat sangat tertarik dan 23.03% tertarik dengan gel antiseptic.Kata kunci: Manggis, Desa Sayang, Sabun Cair Antiseptik, Gel Antiseptik
Seed morphology and anatomy of Hypericum majus (A. Gray) Britton
Authors: Szkudlarz Piotr , Celka Zbigniew , Rosadziński Stanisław , Wojciechowicz Maria Katarzyna 
Published: February 2020

Abstract

Hypericum majus (A. Gray) Britton is an alien species for Europe. It originates from North America and, in recent years, has been spreading in Europe. Presently, this species is found in Germany, France, Italy, Bosnia and Herzegovina, and Belarus. In Poland, it was noted for the first time in 2017 in western part of the country. Thus far, no detailed morphology and anatomy of H. majus seeds based on light and electron microscopy studies has been presented. Considering the fact that seeds provide important taxonomical information and the discussed species has not been investigated in this respect, in this research, an attempt was made to broaden the present knowledge.
Investigations were conducted based on samples originating from three localities in Central Europe (Poland). The obtained results showed that H. majus seeds are very small – about 0.5 mm in length. In the SEM image, their surface is reticulate, typical of majority of species in this genus. Anatomical analysis showed that seed coat of matured seeds is very delicate, composed of two cell layers with strongly lignified walls.
Beneficial Effect of Pachyrhizus erosus Fiber as a Supplemental Diet to Counteract High Sugar-Induced Fatty Liver Disease in Mice
Authors: Santoso Putra , Maliza Rita , Fadhilah Qonitah , Insani Siti Jamalul 
Published: February 2020

Abstract

Background and aims: Edible fiber isolated from the tuber of yam bean (Pachyrhizus erosus, Leguminosae) has been suggested to prevent the development of metabolic diseases caused by excessively consuming sugary foods. However, it is unclarified whether P. erosus fiber (PEF) is also capable of preventing liver diseases. This study aimed to determine the effectivity of PEF in counteracting the development of non-alcoholic fatty liver disease (NAFLD) caused by excessive intake of high-sugar diet (HSD).

Material and method: 25% of PEF in HSD (w/w) was fed in BALB/c mice for eight weeks followed by subsequent morphological and histological examinations of the liver at the end of treatment in comparing with HSD alone.

Results: We found that supplementation of 25% PEF sustained the normal morphological feature of the liver in HSD-fed mice. Moreover, PEF also prevented the development of microvesicles in the liver tissue, nuclear shrinkage, and hepatolysis as indicators of liver disease. Macrophages infiltration as a marker of liver inflammation was also less observed in PEF-treated mice.

Conclusions: PEF could effectively elicit a beneficial effect against NAFLD caused by HSD. Hence, PEF is suggested to be used as a potent supplemental diet to preclude the metabolic diseases caused by HSD.
The Usage of Lasso, Ridge, and Linear Regression to Explore the Most Influential Metabolic Variables that Affect Fasting Blood Sugar in Type 2 Diabetes Patients
Authors: Farbahari Arash , Dehesh Tania , Gozashti Mohammad Hossien 
Published: February 2020

AbstractBackground and aims:To explore the most influential variables of fasting blood sugar (FBS) with three regression methods, to identify the existence chance of type 2 diabetes based on influential variables with logistic regression (LR), and to compare the three regression methods according to Mean Squared Error (MSE) value.Material and Methods:In this cross-sectional study, 270 patients suffering from type 2 diabetes for at least 6 months and 380 healthy people were participated. The Linear regression, Ridge regression, and Least Absolute Shrinkage and Selection Operator (Lasso) regression were used to find influential variables for FBS.Results:Among 15 variables (8 metabolic, 7 characteristic), Lasso regression selected HbA1c, Urea, age, BMI, heredity, and gender, Ridge regression selected HbA1c, heredity, gender, smoking status, and drug use, and Linear regression selected HbA1c as the most effective predictors for FBS.Conclusion:HbA1c is the most influential predictor of FBS among 15 variables according to the result of three regression methods. Controlling the variation of HbA1c leads to a more stable FBS. Beside FBS that should be checked before breakfast, maybe HbA1c could be helpful in diagnosis of Type 2 diabetes.