bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnant Women’s Knowledge About Alcohol Consumption During Pregnancy and its Consequences: An Israeli Survey
Authors: Hen-Herbst Liat , Senecky Yehuda , Tenenbaum Ariel , Berger Andrea 
Published: November 2020

Abstract
Background. Alcohol consumption can negatively affect fetal development, resulting in a range of mental and physical disabilities clinically termed fetal alcohol spectrum disorders (FASD). Despite suspected rates of maternal drinking during pregnancy, the documented number of children diagnosed with FASD in Israel is extremely low. The aim of this study was to investigate alcohol-consumption behavior and knowledge about the consequences of such consumption among pregnant Israeli women.Methods. A sample of 802 pregnant women completed an anonymous online survey related to their backgrounds, recommendations and education on alcohol consumption during pregnancy, general knowledge regarding the consequences of alcohol consumption during pregnancy and FASD, and alcohol they consumed (frequency and amount) 2 mo prior to conception and during pregnancy. Descriptive statistics included means, standard deviations, ranges, and frequencies. Associations between demographic characteristics and alcohol consumption were assessed using chi-square tests, independent sample t tests, one-way analyses of variances, and Spearman correlations. Results. Of the 802 women sampled, 539 (67.2%) reported drinking alcohol in the 2 mo prior to learning they were pregnant, 96 (12%) reported drinking alcohol during their current pregnancy, and 28.1% reported knowing other women who had consumed alcohol during pregnancy. Higher alcohol consumption rates before pregnancy were found among women in their first pregnancies, women with advance education, Jews, and secular women. About 40% of the sample reported they had not received any education about the dangers of consuming alcohol during pregnancy.Conclusions. A high percentage of pregnant women in Israel drank alcohol close to conception and during pregnancy. Although most of the woman ceased drinking after realizing they were pregnant, a still-worrying percentage continued consuming alcohol and had low knowledge and awareness of the plausible dangers of this behavior. Formal dissemination of information on this topic by healthcare professionals treating pregnant woman did not reach many of them. The results emphasize an urgent need for better education of both professionals and the lay public to increase awareness of the consequences of consuming alcohol during pregnancy.
The Relationship Between Hypertriglyceridemic Waist Circumference Phenotype and Gestational Diabetes Mellitus
Authors: Jia Xiao-jiao , Wang Jia-xin , Bai Li-wei , Hua Tian-shu , Han Zhong-hou , Lu Qiang 
Published: November 2020

Abstract
Background: To investigate the correlation between hypertriglyceridemic waist circumference (HTWC) phenotype and gestational diabetes mellitus (GDM).Methods: A total of 1083 patients with gestational age ≤8 weeks were divided into four groups: normal triglyceride and waist circumference group (group A, n=575), simple abdominal obesity group (group B, n=317), simple high triglyceride group (group C, n=125), and HTWC group (group D, n=66). General information and serum biochemical indicators were measured and recorded. Analysis of variance (ANOVA) and logistic regression analysis were used to evaluate the relationship between HTWC with GDM.Results: The prevalence of GDM in the HTWC group was significantly greater than in the other three groups. After adjustment by multivariate logistic regression analysis, the proportion of GDM in the HTWC group was 1.753 times higher than in group A.Conclusion: These findings suggest that there is a significant correlation between HTWC phenotype and GDM, indicating that the HTWC phenotype could be applied as a simple marker for identifying GDM risk factors.
Self-medication practice, its causes and risk factors among people in Tehran, Iran: A descriptive-analytic study
Authors: Onsori Pariya , Esmaeli Faezeh , Abachi Saba , Miremami Mohammad Mahdi , Farahani Amir Mahdi , Nouroozi Pedram , Kazemi Ali , Varpaei Hesam Aldin 
Published: November 2020

Abstract
Background: Self-medication practice unfortunately, is a current issue in different countries. Patterns of self-medication vary among different populations and are influenced by different characteristics. So, this study was aimed at the prevalence of self-medication practice in Tehran. Methods: This descriptive-analytic study was performed from Oct 2019 to March 2020 by a researcher-designed questionnaire among people. The main determinants of the questionnaire included personal information, diet pattern, physical activity, smoking, alcohol consumption, and self-medication habits. Chi-square and Tukey's post hoc tests were used for statistical analysis of data.Results: Eight hundred people participated in this study. The rate of self-medication was 78% among men and 88% among women. 35.75% of the participants had a chronic illness, and 90% of them had a history of self-medication. A significant correlation between gender and self-medication (P = 0.45, r = 0.55), also significant correlation between exercise and self-medication (P = 0.206, r = 0.75), alcohol consumption and self-medication (P= 0.37, r = 0.19) were not seen. Discussion and Conclusion: Education and income levels, chronic diseases, history of drug allergies, smoking, and fast-food consumption seem to create self-medication behavior. Having an old doctor's prescription, saving time, as well as advising family members, were the most important reasons for self-medication. The most commonly used medications were analgesics, common cold medicines, and gastrointestinal drugs. Self-medication was mostly used to treat headaches, migraines, and common cold symptoms such as cough and muscle pain.
Understanding mobile application development and implementation to monitor Posyandu data in Indonesia: a 3-year hybrid action research to build “a bridge” from the community to the national scale
Authors: Rinawan Fedri Ruluwedrata , Susanti Ari Indra , Amelia Indah , Ardisasmita Mulya Nurmansyah , - Widarti , Dewi Rima Kusumah , Ferdian Dani , Purnama Wanda Gusdya , Purbasari Ayi 
Published: November 2020

Abstract
Background. There is a small number of facts available to better understand how mobile health application technology on mother and child health (MCH) is developed. This study is aimed: (a) to explore the process of developing the mobile app in MCH community-based services in the Indonesian setting/ Posyandu ( Pos Pelayanan Terpadu ), (b) to perform feasibility assessment among the community health workers (CHWs), and (c) to see the scalability of the mobile app to the national level in Indonesia. Methods. A hybrid method in which the action research principles and the mixed method, which comprise qualitative and quantitative methods, were synergistically combined for the end-users. The study was conducted in Pasawahan sub-district, Purwakarta, Indonesia from 2017 to 2019. Content analysis, coding, and categorizing were carried out using NVivo 12 Pro for the transcribed data. Wilcoxon Test (2018 and 2019) was conducted using STATA 15 Special Edition. Results. (1) The use of a CHW notebook for data entry in the Posyandu information system book delayed the data reporting process, resulting in the need to develop a mobile app; (2) There are significant differences in CHWs’ knowledge ( p =0.000) and skills ( p =0.0097) on training (2018) and Posyandu phases (2019); (3) There have been 964 Posyandu registered to the Posyandu mobile app from almost all provinces in Indonesia. Conclusions. The 3-year hybrid approach suggests the crucial phases to develop a mobile app in a more user-friendly manner to substitute the use of CHWs’ old-fashion book use, hence its implementation is promising for national use.
“Side effects--part of the package”: A mixed methods approach to study adverse events among patients being programmatically treated for DR-TB in Gujarat, India
Authors: Jakasania Arjunkumar Hardas , shringarpure Kalpita , Kapadia Dixit , Sharma Radhika , Mehta Kedar , Prajapati Arpit , Soundappan Kathirvel 
Published: November 2020

Abstract
Background High rates of Adverse Events (AEs) during treatment is one of the leading causes of unsuccessful treatment outcomes among patients with drug resistant tuberculosis (DR-TB). However, information related to AEs is not systematically collected and managed under programmatic setting. The present study assessed the a) incidence and pattern of adverse events in first three months of DR-TB treatment initiation; b) treatment seeking behaviour for AE management; and c) explore the challenges in seeking treatment and reporting AEs.Methods This mixed methods study included all patients diagnosed and initiated on treatment under RNTCP during July-September 2018 at Ahmedabad DR-TB centre. The patients were interviewed telephonically and assessed for all AEs experienced by them. In-depth interviews and key-informant interviews were conducted among patients, DOTS supervisors and programme staffs (treatment supervisors, medical officer and district program manager). Results Total 207 AEs were reported by the 74 DR-TB patients. All patients experienced at least one AE during initial treatment period. Incidence rate of AEs (experienced) was 3.11 (1st month-4.6, 2nd month-2.7, 3rd month-2.02) per 100 person days. Of the 207 AEs, gastro-intestinal (59, 28.3%), ophthalmic (32, 15.4%) and otolaryngology (25, 11.9%) system related AEs were commonly experienced. Treatment was not sought in two-fifths of the AEs. Themes and sub-themes related to challenges in treatment seeking or reporting of AEs were 1) Patient related-Misconceptions, accessibility and affordability of management, lack of counselling support, stigma and discrimination, and past treatment experience; 2) Health system related- lack of guidelines and training for AE management, 3) Poor coordination between hospital and tuberculosis centre. Conclusion The incidence of AEs was high among patients with DR-TB in the first three months of treatment and treatment seeking/reporting was low. Adequate health education and counselling of the patient and orientation of the health systems are the need of the hour. An efficient real-time reporting and management of AE should be developed and tested for effective DR-TB control.
A packaged intervention to improve viral load monitoring within a deeply rural health district of South Africa
Authors: Brijkumar Jaysingh , Johnson Brent , Zhao Yuan , Edwards Alex , Moodley Pravi , Pathan Khairoonisa , Pillay Selvan , Castro Kenneth , Sunpath Henry , Kuritzkes Dan , Moosa Yunus , Marconi Vincent 
Published: November 2020

Abstract
Background: The KwaZulu-Natal (KZN) province of South Africa has the highest prevalence of HIV infection in the world. Viral load (VL) testing is a crucial tool for clinical and programmatic monitoring. Within uMkhanyakude district, VL suppression rates were 91% among patients with VL data; however, VL performance rates averaged only 38·7%. The objective of this study was to determine if enhanced clinic processes and community outreach could improve VL monitoring within this district. Methods: A packaged intervention was implemented at three rural clinics in the setting of the KZN HIV AIDS Drug Resistance Surveillance Study. This included file hygiene, outreach, a VL register and documentation revisions. Chart audits were used to assess fidelity. Outcome measures included percentage VL performed and suppressed. Each rural clinic was matched with a peri-urban clinic for comparison before and after the start of each phase of the intervention. Monthly sample proportions were modelled using quasi-likelihood regression methods for over-dispersed binomial data.Results: Mkuze and Jozini clinics increased VL performance overall from 33·9% and 35·3% to 75·8% and 72·4%, respectively which was significantly greater than the increases in the comparison clinics (RR 1·86 and 1·68, p<0·01). VL suppression rates similarly increased overall by 39·3% and 36·2% (RR 1·84 and 1·70, p<0·01). The Chart Intervention phase showed significant increases in fidelity 16 months after implementation.Conclusions: The packaged intervention improved VL performance and suppression rates overall but was significant in Mkuze and Jozini. Larger sustained efforts will be needed to have a similar impact throughout the province.
Socio-cultural and economic barriers, and facilitators influencing men’s involvement in antenatal care including HIV testing: A qualitative study from urban Blantyre, Malawi
Authors: Sakala Doreen , Kumwenda Moses K. , Conserve Donaldson F. , Ebenso Bassey , Choko Augustine Talumba 
Published: November 2020

Abstract
Background: Male partner involvement in antenatal care (ANC) is associated with positive maternal and neonatal outcomes. However, only a handful of men attend ANC with their partners. This study aimed to understand the underlying barriers and facilitators influencing men’s ANC attendance including HIV testing in Blantyre, Malawi. Methods: Data were collected during a formative qualitative study of a cluster-randomised trial. Six focus group discussions (FGDs) with 42 men and women and 20 in-depth interviews (IDIs) were conducted at three primary health centres in urban Blantyre, Malawi. FGD participants were purposively sampled with IDI participants subsequently sampled after FGD participation. Thematic analysis was used to analyse the data. Results: The economic requirement to provide for their families exerted pressure on men and often negatively affected their decision to attend ANC together with their pregnant partners despite obvious benefits. Peer pressure and the fear to be seen by peers queueing for services at ANC, an environment traditionally viewed as a space for women and children made men feel treated as trespassers and with some level of hostility rendering them feeling emasculated when they attend ANC. Health system problems associated with overall organization of the ANC services, which favours women created resistance among men to be involved. An association between ANC and HIV testing services discouraged men from attending ANC because of their fear of testing HIV-positive in the presence of their partners. The availability of a male friendly clinic offering a private, quick, supportive/sensitive and flexible service was considered to be an important incentive that would facilitate male men’s ANC attendance. Men described compensation to cover transport and opportunity cost for attending the clinic as a motivator to attending ANC services and accepting an HIV test. Conclusion: Peer and economic influences were the most influential barriers of men attending ANC and testing for HIV with their pregnant partners. Addressing these socio-economic barriers and having a male friendly clinic are promising interventions to promote male ANC attendance in this setting.
Determinants of Anxiety and Depression in Patients with Cubital Tunnel Syndrome
Authors: jia siming , Shi Xiaoying , Liu Guanglian , Wang Li , Zhang Xiaoran , Ma Xuelin , li jia , shao xinzhong 
Published: November 2020

Abstract
Background:: The aim of this cross-sectional study to assess the proportions of anxiety and depression in patients with CuTS, and to explore the associated demographic and clinical features.Methods: From May 2011 to January 2017, 246 patients diagnosed with CuTS were recruited. The Hospital Anxiety and Depression Scale was used to assess the proportions of depression and anxiety. Patient demographic and clinical data were collected. Univariate analysis and multivariate regression were carried out to identify the variables that were independently associated with anxiety and depression. Results: The proportions of depression and anxiety were 17.8% (n=44) and 14.2% (n=35), respectively. Five patients had both possible/probable anxiety and depression. Logistic regression analysis revealed that diabetes mellitus was independently associated with depression; and the modified McGowan grade was independently associated with anxiety. Conclusions: In patients with CuTS, the proportions of depression and anxiety were 18% and 14%, respectively. Early screening for anxiety and depression is beneficial for patients with CuTS.
Efficacy of prophylactic methylprednisolone on reducing the risk of post-extubation stridor in patients after an emergency intubation: study protocol for a randomized controlled trial
Authors: Wang Jingyi , Walline Joseph Harold , Yin Lu , Dai Yili , Dai Jiayuan , Zhu Huadong , Yu Xuezhong , Xu Jun 
Published: November 2020

Abstract
Background: Post-extubation stridor (PES) is one of the most common complications of invasive respiratory support, with severe cases leading to possible extubation failure (reintubation within 48 hours) and increased mortality. Previous studies confirmed that prophylactic corticosteroids play an important role in reducing the risk of PES and extubation failure. However, few studies have looked at the efficacy of corticosteroids on preventing PES in patients after an emergency intubation.Aim: To evaluate whether a single dose of methylprednisolone given over a set timeframe before extubation is effective in preventing PES in patients after an emergency intubation.Methods: A multicenter, randomized, placebo-controlled trial will be performed in an emergency department (ED) setting. The trial will include 132 patients who fail a cuff-leak test (CLT) prior to the intervention. Patients will be randomly assigned to either intravenous methylprednisolone (40mg) or placebo four hours prior to extubation. Other eligible patients who pass the CLT will be included in a non-intervention (observation) group. The primary endpoint is the incidence of PES within 48 hours after extubation. Secondary endpoints include oxygen therapy, respiratory support requirements, reintubation secondary to PES, adverse effects within 48 hours after extubation, hospital length of stay and hospital mortality.Discussion: Patients who are intubated on an emergency basis have a higher risk of intubation-related complications. Previous studies have examined treatment regimens involving more than 10 different variations on corticosteroid treatments for PES prevention, while for ED therapy only a simple and effective treatment would be appropriate. Corticosteroid administration is usually accompanied by adverse effects, thus this study will be important for further risk stratification among intubated ED patients. Trial registration: Chictr.org.cn, ChiCTR2000030349. Registered on 29 Feb 2020.
The accuracy and safety of CT-guided iodine-125 seeds implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma.
Authors: Jiang Weijuan , Jiang Ping , Wei Shuhua , Jiang Yuliang , Ji Zhe , Sun Haitao , Fan Jinghong , Li Weiyan , Shao Yuxia , Wang Junjie 
Published: November 2020

Abstract
Purpose: To investigate the accuracy, dosimetric parameters and safety of 3D-printing non co-planar template (3D-PNCT) assisted CT-guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas.Methods and materials: We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needles insertion position, angular and the needle tips distance deviations of preoperative plan with that of intra-operative in brachytherapy treatment-planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intra-operative real-time plan and postoperative plan, including D90, D100 (the dose to 90% and 100% of the target volume), V100, V150 and V200 (the volume receives 100%, 150% and 200% of the prescribed doses). The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), homogeneity index (HI) of the targets were compared among preoperative plan, intra-operative real-time plan and postoperative plan. The peri-operation complications and RSI-BT related toxicity were assessed.Results: The median follow-up was 8.2 months (range 1-18.5months). One patient lost follow-up after RSI-BT. 14 patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0-30). The mean angular deviation was 2.70 ± 3.00 degrees (range, 0-20). The needles tip distances deviation was 6.90 ± 6.00 mm (range, -30-28). D90 for preoperative plan, intra-operative plan and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04,128.98 ± 22.75. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p=0.036). Four lesions reached CR, six lesions reached PR, three lesions were SD and three lesions was PD. Four patients with moderate pain became mild, two with mild pain relived completely after RSI-BT. The others parameters showed no differences among preoperative plan, intraoperative plan and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side-effects were observed.Conclusion: CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate and feasible strategy for recurrent carcinomas located in retroperitoneal regions.
Contraceptive use among sexually active female adolescent in Ethiopia:&nbsp;Trends and determinants insight from national demographic and health survey
Authors: Olika Alemi Kebede , Kitila Sena Belina , Terfa Yonas Biratu , Olika Ayantu Kebede 
Published: November 2020

Abstract
Background: Sexual and reproductive health and right of young people is a global priority as the reproductive choices made by them have a massive impact on their health and wellbeing, education and economy. Teenage pregnancy is a burning public health issue and a demographic challenge in Ethiopia. The use of contraceptive method is a most effective way for sexually active adolescent to prevent pregnancy and its related complication. However, little is known about the trends in contraceptive use and its determinant among girls aged 15 to 19 in Ethiopia. Therefore, this study was designed to examine the trends and correlates of contraceptive use among sexually active adolescents in Ethiopia by using Ethiopian demographic and health survey data.Methods: Four Ethiopian demographic and health survey data were used to examine trends of contraceptive methods use among sexually active adolescent girls. To identify factors associated with contraceptive use, the 2016 Ethiopian demographic and health survey data were used. The data was accessed from the demographic and health survey program data base and data for sexually active adolescent girls were extracted. Data analysis was done using SPSS version 21. Data were weighted for analysis. Descriptive analysis was used to describe independent variables of the study. Multivariable logistic regression model was used to identify factors associated with contraceptive use.Results: Contraceptive method use was increased significantly from 6.9% in 2000 to 39.6% in 2016 among sexually active adolescent girls in Ethiopia. The odds of contraceptive use were lower among female adolescent who had no formal education (AOR= 0.044; 95% CI= 0.008–0.231) and attended primary education (AOR= 0.101; 95% CI= 0.024–0.414). But the odds of contraceptive methods use were higher among adolescents in rich wealth status (AOR= 3.662; 95% CI =1.353–9.913) and those who were told about family planning during their health facility visits (AOR= 3.115; 95% CI= 1.385–7.007)Conclusion: Contraceptive method use was increased significantly among sexually active adolescent girls in Ethiopia in the year 2000 to 2016. Wealth status, educational status and information about family planning during their health facility visits were factors associated with contraceptive use. Improving economic and educational status of young women may help in improving contraceptive use in Ethiopia.