bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual order of Chinese ink paintings
Authors: Fan Zhen-Bao , Zhang Kang 
Published: October 2020

AbstractVisual order is one of the key factors influencing the aesthetic judgment of artworks. This paper reports the results of evaluating the influence of extracted features on visual order in Chinese ink paintings, using a regression model. We use nine contemporary artists’ paintings as examples and extract features related to the visual order of their paintings. A questionnaire survey is conducted to collect people’s rating scores on the visual order. Via regression modeling, our research analyzes the significance of each feature and validates the influences of the features on the visual order.
Problem severity and waiting times for young people accessing mental health services
Authors: Edbrooke-Childs Julian , Deighton Jessica 
Published: October 2020

Background
Access to timely care is a quality standard underpinning many international healthcare models, and long waiting times for child and adolescent mental health services are often reported as a barrier to help-seeking.

Aims
The aim of this study was to examine whether young people with more severe problems have shorter waiting times for mental health services.

Method
Multilevel multinomial regression analysis controlling for service-area deprivation, age, gender, ethnicity, referral source and contextual factors was conducted on N = 21 419 episodes of care (mean age 12.37 years (s.d. = 3.71), 11 712 (55%) female) using data from child and adolescent mental health services.

Results
There was high variation in waiting times, which ranged from 0 days to 1629 days (mean 50.65 days (s.d. = 78.03), median 32 days). Compared with young people with less severe problems young people with severe problems, self-harm, psychosis or eating disorders were less likely to experience longer waiting times. Moreover, referrals from sources other than primary care were generally less likely to have longer waiting times than referrals from primary care sources, especially referral from accident and emergency services.

Conclusions
The findings suggest that young people with more severe problems had shorter waiting times. Intermediary information and resources for support before access to services is needed to prevent escalation of problems and to support individuals and families while waiting for care. Interventions to reduce waiting times should be considered without compromising on the quality and experience of care that young people and families deserve when seeking help.
Patterns of use of secondary mental health services before and during COVID-19 lockdown: observational study
Authors: Tromans Samuel , Chester Verity , Harrison Hannah , Pankhania Precina , Booth Hanna , Chakraborty Nandini 
Published: October 2020

Background
The coronavirus disease 2019 (COVID-19) pandemic has had a profound impact on both the physical and mental well-being of the global population. Relatively few studies have measured the impact of lockdown on utilisation of secondary mental health services in England.

Aims
To describe secondary mental health service utilisation pre-lockdown and during lockdown within Leicestershire, UK, and the numbers of serious incidents during this time frame.

Method
Data pertaining to mental health referral and hospital admissions to adult mental health, child and adolescent mental health, intellectual disability and mental health services for older people were collated retrospectively from electronic records for both 8 weeks pre-lockdown and the first 8 weeks of lockdown in England. Serious incidents during this time frame were also analysed.

Results
Significantly (P < 0.05) reduced referrals to a diverse range of mental health services were observed during lockdown, including child and adolescent, adult, older people and intellectual disability services. Although admissions remained relatively stable before and during lockdown for several services, admissions to both acute adult and mental health services for older people were significantly (P < 0.05) reduced during lockdown. Numbers of serious incidents in the pre-lockdown and lockdown periods were similar, with 23 incidents pre-lockdown, compared with 20 incidents in lockdown.

Conclusions
To the best of our knowledge, this is the first UK-based study reporting patterns of use of mental health services immediately prior to and during COVID-19 lockdown. Overall numbers of referrals and admissions reduced following commencement of COVID-19 lockdown. Potential reasons for these observations are discussed.
Risk of depression in family caregivers: unintended consequence of COVID-19
Authors: Gallagher Stephen , Wetherell Mark A. 
Published: October 2020

Background
Coronavirus disease 2019 (COVID-19) is likely to exacerbate the symptoms of poor mental health in family caregivers.

Aims
To investigate whether rates of depressive symptomatology increased in caregivers during COVID-19 and whether the unintended consequences of health protective measures, i.e., social isolation, exacerbated this risk. Another aim was to see if caregivers accessed any online/phone psychological support during COVID.

Method
Data (1349 caregivers; 6178 non-caregivers) was extracted from Understanding Society, a UK population-level data-set. The General Health Questionnaire cut-off scores identified those who are likely to have depression.

Results
After adjustment for confounding caregivers had a higher risk of having depressive symptoms compared with non-caregivers, odds ratio (OR) = 1.22 (95% CI 1.05–1.40, P = 0.008) evidenced by higher levels of depression pre-COVID-19 (16.7% caregivers v. 12.1% non-caregivers) and during the COVID-19 pandemic (21.6% caregivers v. 17.9% non-caregivers), respectively. Further, higher levels of loneliness increased the risk of depression symptoms almost four-fold in caregivers, OR = 3.85 (95% 95% CI 3.08–4.85, P < 0.001), whereas accessing therapy attenuated the risk of depression (43%). A total of 60% of caregivers with depression symptoms reported not accessing any therapeutic support (for example online or face to face) during the COVID-19 pandemic.

Conclusions
COVID-19 has had a negative impact on family caregivers’ mental health with loneliness a significant contributor to depressive symptomatology. However, despite these detriments in mental health, the majority of caregivers do not access any online or phone psychiatric support. Finally, psychiatric services and healthcare professionals should aim to focus on reducing feelings of loneliness to support at-risk caregivers.
Transnationality and Coloniality in the Concept of Modern Korean Literature
Authors: Cho Heekyoung 
Published: October 2020

Abstract
This article discusses the discourse that appears in early theorizations of Korean literature through an examination of Yi Kwang-su’s theory of literature and related Russian and Japanese theories in colonial Korea. During the process of this formation, Korean intellectuals used the term “munhak” as a translation for “literature,” before there were any substantial works of “modern” literature in Korean. Yi’s theory of modern literature was translational and transnational from its inception, symptomatically revealing its coloniality, which became more complicated during the later colonial period. Yi frequently stressed Tolstoy’s influence on him while downplaying the impact of Japanese theorists whose ideas he used at least as much. Yi’s emphasis on Russian texts and on the materiality of Korean vernacular script, I argue, may be an indication of a colonial incongruity and predicament in which he struggled to conceal the coloniality of his own literary theory and, by extension, the coloniality of modern Korean literature. I hope that this paper will provide a better understanding of how modern theories of literature were entrenched in the complications of colonization from their foundation.
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Authors: Guo Wanxu , Gao Hang , Pan Wei , Yu Panapn , Che Guanghua 
Published: October 2020

ABSTRACT
Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear. This study investigated the regulatory role of Smad3, ezrin, and protein kinase A (PKA) in NADPH oxidase (Nox4) expression, reactive oxidative species (ROS) production, and apoptosis in HG-treated podocytes. A human podocyte cell line was cultured and differentiated, then treated with 30 mM HG. Apoptosis and intracellular ROS levels were assessed using TUNEL and DCF assays, respectively. Expressions of Nox4, phospho-Smad3Ser423/425, phospho-PKAThr197, and phospho-ezrinThr567 were evaluated using western blotting. ELISA was used to quantify intracellular cAMP concentration and PKA activity. Knockdown assay was used to inhibit the expressions of Smad3, Nox4, and ezrin by lentiviral shRNA. In HG-treated podocytes, the level of phospho-Smad3Ser423/425 and phospho-ezrinThr567 was increased significantly, which was accompanied by the reduction of cAMP and phospho-PKAThr197. HG-induced apoptosis was significantly prevented by the Smad3-inhibitor SIS3 or shRNA-Smad3. In podocytes expressing shRNA-ezrin or shRNA-Nox4, apoptosis was remarkably mitigated following HG treatment. HG-induced upregulation of phospho-ezrinThr567 and downregulation of phospho-PKAThr197 was significantly prevented by SIS3, shRNA-ezrin or shRNA-Smad3. Forskolin, a PKA activator, significantly inhibited HG-mediated upregulation of Nox4 expression, ROS generation, and apoptosis. Additionally, an increase in the ROS level was prohibited in HG-treated podocytes with the knockdown of Nox4, Smad3, or ezrin. Taken together, our findings provided evidence that Smad3-mediated ezrin activation upregulates Nox4 expression and ROS production, by suppressing PKA activity, which may at least in part contribute to HG-induced podocyte apoptosis.
The twists and turns of left-right asymmetric gut morphogenesis
Authors: Grzymkowski Julia , Wyatt Brent , Nascone-Yoder Nanette 
Published: October 2020

ABSTRACT
Many organs develop left-right asymmetric shapes and positions that are crucial for normal function. Indeed, anomalous laterality is associated with multiple severe birth defects. Although the events that initially orient the left-right body axis are beginning to be understood, the mechanisms that shape the asymmetries of individual organs remain less clear. Here, we summarize new evidence challenging century-old ideas about the development of stomach and intestine laterality. We compare classical and contemporary models of asymmetric gut morphogenesis and highlight key unanswered questions for future investigation.
Additive effects of temperature and water availability on pregnancy in a viviparous lizard
Authors: Brusch George A. , Gavira Rodrigo S. B. , Viton Robin , Dupoué Andréaz , Leroux-Coyau Mathieu , Meylan Sandrine , Le Galliard Jean-François , Lourdais Olivier 
Published: October 2020

ABSTRACT
One of the greatest current threats to biodiversity is climate change. However, understanding of organismal responses to fluctuations in temperature and water availability is currently lacking, especially during fundamental life-history stages such as reproduction. To further explore how temperature and water availability impact maternal physiology and reproductive output, we used the viviparous form of the European common lizard (Zootoca vivipara) in a two-by-two factorial design manipulating both hydric and thermal conditions, for the first time. We collected blood samples and morphological measurements during early pregnancy and post-parturition to investigate how water availability, temperature and a combination of the two influence maternal phenology, morphology, physiology and reproductive output. We observed that dehydration during gestation negatively affects maternal physiological condition (lower mass gain, higher tail reserve mobilization) but has little effect on reproductive output. These effects are mainly additive to temperature regimes, with a proportional increase in maternal costs in warmer environments. Our study demonstrates the importance of considering combined effects of water and temperature when investigating organismal responses to climate changes, especially during periods crucial for species survival such as reproduction.
The best predictions in experimental biology are critical and persuasive
Authors: Fudge Douglas S. , Turko Andy J. 
Published: October 2020

ABSTRACTA powerful way to evaluate scientific explanations (hypotheses) is to test the predictions that they make. In this way, predictions serve as an important bridge between abstract hypotheses and concrete experiments. Experimental biologists, however, generally receive little guidance on how to generate quality predictions. Here, we identify two important components of good predictions – criticality and persuasiveness – which relate to the ability of a prediction (and the experiment it implies) to disprove a hypothesis or to convince a skeptic that the hypothesis has merit. Using a detailed example, we demonstrate how striving for predictions that are both critical and persuasive can speed scientific progress by leading us to more powerful experiments. Finally, we provide a quality control checklist to assist students and researchers as they navigate the hypothetico-deductive method from puzzling observations to experimental tests.
Applying an ecological framework to examine the multiple levels of influence affecting the utilisation of private sector adult asthma services in Khartoum, Sudan: a mixed methods study
Authors: Thomson Rachael , Noor Magde , Elsony Asma 
Published: October 2020

Background: Asthma is the third most common cause of hospital visits in Sudan. Sudan has a pluralistic health care system, with a strong and varied private sector. While research examining public sector asthma services exists, very little is known about which asthma services are available in the private sector. Methods: An explanatory sequential mixed-method social ecological approach was used to examine influencing factors of asthma service utilisation in the private sector, considering five levels: policy, organisational, community, familial, individual environment. Quantitative research involved surveying private healthcare facilities to describe asthma services. Qualitative research involved in-depth interviews with asthma patients to explore facility decision-making. Nine private chest clinics, 44 pharmacies, and 21 private hospitals offering asthma services in Khartoum were studied - 46 female and 28 male health providers were surveyed; 7 male and 7 female asthma patients were interviewed. Results: At the health policy level, there is no current asthma management policy for the private sector. At the organisational and health systems level, the survey found low rates of diagnostic equipment available, little asthma-specific training, and little use of asthma treatment cards, guidelines, and registers. At the community level, high levels of stigma from the community were felt by most of the patients interviewed. At the familial level, asthma was often viewed as a hereditary condition, and, as a long-term condition, there were worries about marriage potential and impact on jobs/future activities. At the individual level, patients sought frequent, short-term care at private facilities for acute attacks. The severity of the disease and the major impact it had, particularly on younger adults’, was striking. Conclusions: Applying an ecological framework to examine asthma care management enables review of all levels of service provision: inclusive health policy, government commitment, high quality service delivery, uninterrupted affordable drug supply, community involvement, and patient empowerment.
Acknowledging the gap: a systematic review of micronutrient supplementation in infants under six months of age
Authors: Stelle Isabella , Venkatesan Sruthi , Edmond Karen , Moore Sophie E. 
Published: October 2020

Background: Micronutrient deficiencies remain common worldwide, but the consequences to growth and development in early infancy (under six months of age) are not fully understood. We present a systematic review of micronutrient interventions in term infants under six months of age, with a specific focus on iron supplementation. Methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid) and Embase (Ovid) from January 1980 through December 2019. Interventions included iron or multiple micronutrients (MMNs). Results: Of 11,109 records identified, 32 publications from 23 trials were included (18 iron and five MMN supplementation trials). All 23 trials evaluated the effect of supplementation on biochemical outcomes, ten reported on growth, 14 on morbidity and/or mortality and six on neuro-behavioural development. Low- and middle- income countries made up 88% (21/24) of the total trial locations. Meta-analysis was not possible due to extensive heterogeneity in both exposure and outcome measures. However, these trials indicated that infants less than six months of age benefit biochemically from early supplementation with iron, but the effect of additional nutrients or MMNs, along with the impacts on growth, morbidity and/or mortality, and neuro-behavioural outcomes remain unclear. Conclusions: Infants less than six months of age appear to benefit biochemically from micronutrient supplementation. However, well-powered randomised controlled trials are required to determine whether routine supplementation with iron or MMNs containing iron should commence before six months of life in exclusively breast-fed infants in low-resource settings.
Retroreflective spatial-polarization interferometer
Authors: Sokolov A. L. , Murashkin V. V. 
Published: October 2020

The interference of the beams reflected from a combination of two
deployed cube-corner reflectors with a special interference
phase-shifting coating is considered. It is shown that in this case a
beam with an axisymmetric polarization structure appears. Particular
attention is paid to the various optical vortices, which are formed if
polarization of light is circular. It is proposed to use this system
to create a retroreflective interferometer, in which the spatial
polarization structure sensitivity changes due to the path difference
between the beams, reflected from two different corner-cube
reflectors. It is installed such that the position of the plane of
vector

E

oscillations rotates with azimuth
variation in the transverse plane, while at different angular
distances from the beam axis this rotation can occur in opposite
directions, i.e., we observed a counter-twisted polarization structure, useful for
manipulating small particles.
Dynamic 5G RAN slice adjustment and migration based on traffic prediction in WDM metro-aggregation networks
Authors: Yu Hao , Musumeci Francesco , Zhang Jiawei , Tornatore Massimo , Bai Lin , Ji Yuefeng 
Published: October 2020

5G radio access network (RAN) slicing has recently been proposed to adapt service provision over substrate network resources to the diversified requirements of 5G services in terms of bandwidth, computation, latency, and reliability. 5G RAN slicing allows baseband processing functions, including centralized units and distributed units, to be deployed in the substrate network according to the different service requirements. Even though existing studies have shown how to perform 5G RAN slicing to flexibly provision service according to their initial requirements, a proper dynamic RAN slice adjustment and migration strategy is also required to accommodate the highly dynamic nature of mobile traffic while maintaining lower service blocking. In this paper, we provide a traffic-prediction-based strategy for dynamic 5G RAN slice adjustment and migration in wavelength division multiplexing (WDM) metro-aggregation networks, which targets the minimization of (1) the slice degradation penalty, which accounts for both the degradation degree and slice priority, and (2) the migrated traffic during slice migration. Our numerical results show that the proposed strategy can effectively reduce the penalty and slice migration.
Anomalous slowdown of pump light in Raman fiber lasers
Authors: Wang Wenchao , Xian Tianhao , Gao Lirun , Zhang Wenyan , Zhan Li 
Published: October 2020

Usually, the pump light in lasers should perform fast light owing to operating in the absorption band. In this study, we observe and demonstrate anomalous slowdown of the pump light in a Raman fiber laser. Experiments show that the pump light can be slowed down to sub-nanoseconds at a repetition rate of 50–500 MHz. Theoretical analysis shows that the hole-burning effect is formed at the Raman gain spectrum in the saturation regime, which imposes on the pump light by normal dispersion. Consequently, the pump light experiences an unusual slow light effect rather than the fast light effect after absorption. We believe it has promising potentials in the improvement of ultrashort pulse generation, and may have significant influence on improving the conversion efficiency in pulse-pumped laser systems.
THE ADOPTION OF AUTOMATED FiO2 CONTROL INTO POLISH NICUS: 2012-2019
Authors: Bachman Thomas Edward , Wilinska Maria , Piwowarczyk Pawel , Skrzypek Michal 
Published: October 2020

The introduction and adoption of new technology in medicine is a continuous ever present process but it is often not studied. Insights gained from documenting such experiences can not only guide local practices but also provide valuable quality benchmarks. Automated control of FiO2 based on continuous SpO2 (A-FiO2) not only reduces the challenging task of manual oxygen titration, but also has the potential to greatly improve the morbidity and mortality of extremely preterm infants. First approved for use in Europe in 2012, it is now available on most infant ventilators outside the USA. Poland was the first region in Europe to implement its clinical use. We report experience from 619 infants from 12 centers recorded in a web-based registry established in 2013 to document its use. We found the A‑FiO2 was primarily used in the first week of life in intubated infants. However it is also successfully applied in both noninvasively supported infants and in those who were difficult to wean from oxygen and who exhibited frequent desaturations. We also found the SpO2 target range and alarm setting are not different from normal manual titration, although wider settings are also used and promise some benefit. Finally we report our plan to gather data from a national data base and detailed surveys. The surveys will document subjective aspects of this experience from a core group of centers. Details of the surveys are included and cover: experience with training and acceptance, changes in practice associated with the years of experience and barriers to broader use.