bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory markers associated with COVID‐19 progression in patients with or without comorbidity: A retrospective study
Authors: Chen Zaishu , Zhang Furong , Hu Weihua , Chen Qijian , Li Chang , Wu Longlong , Zhang Zhuheng , Li Bin , Ye Qifa , Mei Jin , Yue Jiang 
Published: October 2020

AbstractObjectivesTo investigate laboratory markers for COVID‐19 progression in patients with different medical conditions.MethodsWe performed a multicenter retrospective study of 836 cases in Hubei. To avoid the collinearity among the indicators, principal component analysis (PCA) followed by partial least squares discriminant analysis (PLS‐DA) was performed to obtain an overview of laboratory assessments. Multivariable logistic regression analysis and multivariable Cox proportional hazards regression analysis were respectively used to explore risk factors associated with disease severity and mortality. Survival analysis was performed in patients with the most common comorbidities.ResultsLactate dehydrogenase (LDH) and prealbumin were associated with disease severity in patients with or without comorbidities, indicated by both PCA/PLS‐DA and multivariable logistic regression analysis. The mortality risk was associated with age, LDH, C‐reactive protein (CRP), D‐dimer, and lymphopenia in patients with comorbidities. CRP was a risk factor associated with short‐term mortality in patients with hypertension, but not liver diseases; additionally, D‐dimer was a risk factor for death in patients with liver diseases.ConclusionsLactate dehydrogenase was a reliable predictor associated with COVID‐19 severity and mortality in patients with different medical conditions. Laboratory biomarkers for mortality risk were not identical in patients with comorbidities, suggesting multiple pathophysiological mechanisms following COVID‐19 infection.
SNHG5/miR‐582‐5p/RUNX3 feedback loop regulates osteogenic differentiation and apoptosis of bone marrow mesenchymal stem cells
Authors: Zheng Jiwei , Guo Hongliang , Qin Ying , Liu Zongxiang , Ding Zhijiang , Zhang Lei , Wang Wanqing 
Published: October 2020

AbstractOsteoporosis is one of the most prevailing orthopedic diseases that causes a heavy burden on public health. Given that bone marrow‐derived mesenchymal stem cells (BMSCs) are of immense importance in osteoporosis development, it is necessary to expound the mechanisms underlying BMSC osteoblastic differentiation. Although mounting research works have investigated the role of small nucleolar RNA host gene 5 (SNHG5) in various diseases, elucidations on its function in osteoporosis are still scarce. It was observed that SNHG5 and RUNX family transcription factor 3 (RUNX3) were remarkably elevated during osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). Further, we disclosed that the silencing of SNHG5 suppressed osteogenic differentiation and induced apoptosis of hBMSCs. What's more, SNHG5 acted as a competing endogenous RNA to affect RUNX3 expression via competitively binding with microRNA (miR)‐582‐5p. RUNX3 was also confirmed to simulate the transcriptional activation of SNHG5. Finally, our findings manifested that the positive feedback loop of SNHG5/miR‐582‐5p/RUNX3 executed the promoting role in the development of osteoporosis, which shed light on specific molecular mechanism governing SNHG5 in osteogenic differentiation and apoptosis of hBMSCs and indicated that SNHG5 may represent a novel target for the improvement of osteoporosis therapy.
Tetrahydroxy stilbene glycoside attenuates acetaminophen‐induced hepatotoxicity by UHPLC‐Q‐TOF/MS‐based metabolomics and multivariate data analysis
Authors: Gao Yan , Li Jun‐Tong , Li Xiang , Li Xun , Yang Song‐Wei , Chen Nai‐Hong , Li Lin , Zhang Lan 
Published: October 2020

AbstractTetrahydroxy stilbene glycoside (TSG) is a main active compound in Polygonum multiflorum. Acetaminophen (APAP) is a well‐known analgesic and antipyretic drug. It is considered to be safe within a therapeutic range, in case of acute intoxication hepatotoxicity occurs. This present study aims to observe TSG‐provided alleviation on APAP‐induced hepatoxicity in C57BL/6 mice. APAP performs extensive necrosis and dissolves nucleus suggesting liver damage from hepatic histopathology. Serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase analysis and liver histological evaluation showed that TSG reduced the hepatotoxicity induced by a toxic dose of APAP. Moreover, TSG alone had no hepatotoxicity. TSG eliminated hepatic glutathione depletion and cysteine adducts formation. It also reduced the expression of interleukin‐10 and lowered the production of reactive oxygen species in liver tissues. Luminex was used to detect cytokine production in different groups. Herein, we used an untargeted metabolomics approach by performing ultrahigh‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry on treated mice to identify metabolic disruptions under APAP and TSG. Major alterations were observed for purine metabolism, amino acid metabolism, and fatty acid metabolism. These data provide metabolic evidence and biomarkers in the liver that the ABC transporters, Glycine serine and threonine metabolism, and Choline metabolism in cancer changed the most. These targets of metabolites have the potential to improve our understanding of homeostatic. Meanwhile, these metabolites revealed that TSG can alleviate inflammation caused by APAP and promote the activity of intrinsic antioxidants. In summary, TSG can regulate lipid metabolism, promote the production of antioxidant enzymes, and decrease the inflammatory response.
The Effects of Clinical and Home‐based Physiotherapy Programs in Secondary Head and Neck Lymphedema
Authors: Ozdemir Kadirhan , Keser Ilke , Duzlu Mehmet , Erpolat Ozge P. , Saranli Uluc , Tutar Hakan 
Published: October 2020

Objectives/HypothesisTo determine the effects of complex decongestive physiotherapy (CDP) and home programs on external lymphedema, staging of lymphedema, fibrosis, and three‐dimensional (3D) surface scanning and volume evaluation in head and neck lymphedema.Study DesignA prospective randomized controlled study.MethodsTwenty‐one patients were randomly divided into three groups: CDP (n:7), home program (n:7), and control (n:7). Assessment methods were applied at baseline and 4 weeks later for all groups. MD. Anderson Cancer Center Head and Neck Lymphedema Protocol was implemented to evaluate head and neck external lymphedema, staging of lymphedema, and fibrosis. A 3D scanner and a software were used to determine and calculate the volume of the head and neck region via 3D surface scanning. Head and neck external lymphedema and fibrosis assessment criteria were performed to evaluate visible soft tissue edema and the degree of stiffness.ResultsThe severity and volume of lymphedema decreased in the CDP program group (P < .05). Besides, external lymphedema and fibrosis at submental region were decreased in both CDP program and home program groups (P < .05).ConclusionsWhile the benefits of home program are limited, a CDP program may be more effective in the management of lymphedema and fibrosis in patients diagnosed with head and neck cancer.The clinical trial registration number: NCT04286698, date: 02/25/2020, retrospectively registered.Level of Evidence4 Laryngoscope, 131:E1550–E1557, 2021
Bounds on the spectra of Schur complements of large H‐TFETI‐DP clusters for 2D Laplacian
Authors: Dostál Zdeněk , Horák David , Brzobohatý Tomáš , Vodstrčil Petr 
Published: October 2020

AbstractBounds on the spectrum of Schur complements of subdomain stiffness matrices of the discretized Laplacian with respect to interior variables are important in the convergence analysis of finite element tearing and interconnecting (FETI)‐based domain decomposition methods. Here, we are interested in bounds on the regular condition number of Schur complements of “floating” clusters, that is, of matrices comprising the Schur complements of subdomains with prescribed zero Neumann conditions that are joined on the primal level by edge averages. Using some known results, angles of subspaces, and known bounds on the spectrum of Schur complements associated with square domains, we give bounds on the regular condition number of the Schur complement of some “floating” clusters arising from the discretization and decomposition of 2D Laplacian on domains comprising square subdomains. The results show that the condition number of the cluster defined on a fixed domain decomposed into m × m square subdomains joined by edge averages increases proportionally to m. The estimates are compared with numerical values and used in the analysis of H‐FETI‐DP methods. Though the research has been motivated by an effort to extend the scope of scalability of FETI‐based solvers to variational inequalities, the experiments indicate that H‐TFETI‐DP with large clusters can be useful for the solution of huge linear elliptic problems discretized by sufficiently regular grids.
Footbath as a safe, simple, and non‐pharmacological method to improve sleep quality of menopausal women
Authors: Aghamohammadi Vahideh , Salmani Roghayeh , Ivanbagha Reyhaneh , Effati daryani Fatemeh , Nasiri Khadijeh 
Published: October 2020

AbstractDue to the adverse effects of medication we decided to provide a safe, economic, and easy intervention to decrease sleep problems in menopausal women. This trial aimed to determine the effect of footbath on sleep disturbance in postmenopausal women. One hundred menopausal women were randomly stratified using a permuted block randomization procedure by Random Allocation Software, and assigned to one of two study groups: control (without intervention, n = 50) and intervention (footbath, n = 50). The footbath group was asked to lie their feet into the warm water for 20 min in a container with a depth of 10 cm one hour before the usual sleeping time for 6 weeks. To assess sleep quality, we used the Pittsburgh sleep quality index (PSQI). To evaluate severity of menopause symptoms, the Greene scale was applied. Before the intervention, 96% of the subjects in the footbath group and 94% in the control group were poor sleepers. The results of analysis of covariance showed significant improvement in sleep quality and decrease in severity of menopause signs in the footbath group compared to the control group. At the baseline, there was a statistically significant correlation between the severity of menopause signs and the global score of PSQI in all study individuals (p ≤ .001, r = .464). The present study findings showed that footbath intervention enhanced sleep quality in menopausal women. Thus, footbath as a safe, simple, and non‐pharmacological application can improve quality of life in postmenopausal women and inhibit problems due to inadequate sleep quality.
Using conjoint analysis to examine bias in referral to a behavior intervention program
Authors: Noltemeyer Amity , Kunesh Claire , Harper Erin , Davis Darrel R. 
Published: October 2020

AbstractResearch in the United States suggests that teachers view Black students' misbehavior as more likely to reoccur, but such research has not disentangled the effect of race from related factors. We used conjoint analysis to experimentally test the effect of multiple student characteristics on the chances of being referred for a behavior intervention program. Although preservice teacher participants were not more likely to refer Black students, they were more likely to refer students who had lower grades, lived in poverty, lived with a single mother, and had been retained. We interpret these results and highlight directions for future research and practice.
Nusinersen for spinal muscular atrophy type 1: Real‐world respiratory experience
Authors: Lavie Moran , Diamant Nir , Cahal Michal , Sadot Efraim , Be'er Moria , Fattal‐Valevski Aviva , Sagi Liora , Domany Keren A. , Amirav Israel 
Published: October 2020

AbstractBackgroundThe emergence of new treatments for spinal muscular atrophy (SMA) is revolutionary, especially for SMA type 1 (SMA1). Data on respiratory outcomes remain sparse and rely mostly on randomized clinical trials. We report our experience of Nusinersen‐treated SMA1 patients in real‐world settings.MethodsData from SMA1 patients treated with Nusinersen were prospectively collected between 1/2017 and 1/2020. Respiratory variables included the use of assisted ventilation, the use of mechanical insufflation‐exsufflation (MIE), respiratory complications, and death or treatment cessation due to respiratory reasons.ResultsTwenty SMA1 patients were assessed before and after 2 years of Nusinersen treatment which was initiated at a median age of 13.5 months (range, 1–184). At baseline, 16 patients were using assisted ventilation, eight noninvasive and eight invasive. Twelve patients were using permanent ventilation and four partial ventilation. After 2 years of treatment, there was no change in respiratory support among ventilated patients. All four patients who were free from respiratory support at baseline required the initiation of assisted ventilation during the study period. All 20 patients used MIE after 2 years of treatment. Two patients died from acute respiratory failure and one sustained severe brain injury. Four patients had chronic and/or recurrent atelectasis.ConclusionMost of our patients were stable in their need for assisted ventilation and did not worsen as expected in SMA1, nor did they improve as might be hoped. Future studies are needed to determine if earlier treatment with Nusinersen might result in respiratory outcomes superior to those reported in this real‐life study.
Identifying the relationship between postoperative urinary continence and residual urethra stump measurements in robot assisted radical prostatectomy patients
Authors: Beulens Alexander J. W. , Brinkman Willem M. , Umari Paolo , Koldewijn Evert L. , Hendrikx Ad J. M. , van Basten Jean Paul , van Merriënboer Jeroen J. G. , van der Poel Henk G. , Bangma Chris , Wagner Cordula 
Published: October 2020

ABSTRACTObjectiveTo investigate the feasibility of urethral stump length and width measurements in recorded videos of robot assisted radical prostatectomy procedures using the Kinovea software and to assess if these measurements could be used as predictors of postoperative urinary continence.MethodsFifty‐three patients were selected from an institutional database of 1400 cases and included in the study. All videos were analysed using the computer software ‘Kinovea’. All measurements were performed using the inserted bladder catheter as a reference point.ResultsThe reference point (bladder catheter) was available in 33 out of 53 patients. The median surgical urethral length (SUL) was significantly higher in the continent group (1050 vs. 1294 mm, p = 0.018). The urethral width measurements did not show a difference between the groups. In order to validate the Kinovea software as an accurate tool for the measurement of the urethral stump length and width results were correlated with the magnetic resonance imaging measurements of the urethra.ConclusionsThe results of this study showed a significantly longer median SUL incontinent patients.
Determination of Molar Substitution of γ‐Hydroxypropyl Starch
Authors: Liu Xue‐Li , Zhang Kun , Hu Yu , Zhang Zhengjuan , Chen Jun , Ma TianLin , Wang JiaJia 
Published: October 2020

AbstractA new class of hydroxypropyl starch, γ‐hydroxypropyl starch (γ‐HPS), is synthesized by using 3‐chloropropanol as the etherifying reagent. Two independent procedures for the determination of the number of moles of alkylene oxide combined per anhydroglucose unit (molar substitution, MS) in γ‐HPS are described. The feasibility of the Zeisel‐gas chromatographic technique and colorimetric determination are testified, and especially in the second approach, the stability and accuracy of dehydration process are also investigated. The concentrated sulfuric acid dehydration oxidation is replaced with 2‐iodoxybenzoic acid oxidation while retaining the same acid degradation and the same ninhydrin color reaction. Furthermore, the reliability and the range of application of the methods are tested by analyzing three samples of γ‐HPS and unmodified starch derivatives, and the results indicate that values of MS are in good agreement with each testing method.
Recent Electrokinetic and Microfluidic Strategies for Detection of Amyloid Beta Peptide Biomarkers: Towards Molecular Diagnosis of Alzheimer's Disease
Authors: Van Thanh Nguyen Ngoc , Taverna Myriam , Smadja Claire , Mai Thanh Duc 
Published: October 2020

AbstractAmong all neurodegenerative diseases, Alzheimer's Disease (AD) is the most prevalent worldwide, with a huge burden to the society and no efficient AD treatment so far. Continued efforts have been being made towards early and powerful diagnosis of AD, in the hope for a successful set of clinical trials and subsequently AD curative treatment. Towards this aim, detection and quantification of amyloid beta (Aβ) peptides in cerebrospinal fluid (CSF) and other biofluids, which are established and validated biomarkers for AD, have drawn attention of the scientific community and industry over almost two decades. In this work, an overview on our major contributions over 15 years to develop different electrokinetic and microfluidic strategies for Aβ peptides detection and quantification is reported. Accordingly, discussions and viewpoints on instrumental and methodological developments for microscale electrophoresis, microfluidic designs and immuno‐enrichment / assays on magnetic beads in microchannels for tracing Aβ peptides in CSF are given in this review.
Verification Artifacts in Cooperative Verification: Survey and Unifying Component Framework
Authors: Beyer Dirk , Wehrheim Heike 
Published: October 2020

AbstractThe goal ofcooperativeverification is to combine verification approaches in such a way that they work together to verify a system model. In particular, cooperative verifiersprovideexchangeable information (verification artifacts)toother verifiers orconsumesuch informationfromother verifiers with the goal of increasing the overall effectiveness and efficiency of the verification process.This paper first gives an overview over approaches for leveraging strengths of different techniques, algorithms, and tools in order to increase the power and abilities of the state of the art in software verification. To limit the scope, we restrict our overview to tools and approaches for automatic program analysis. Second, we specifically outline cooperative verification approaches and discuss their employed verification artifacts. Third, we formalize all artifacts in a uniform way, thereby fixing their semantics and providing verifiers with a precise meaning of the exchanged information.
Calculating the primary Lund Jet Plane density
Authors: Lifson Andrew , Salam Gavin P. , Soyez Grégory 
Published: October 2020

Abstract
The Lund-jet plane has recently been proposed as a powerful jet substructure tool with a broad range of applications. In this paper, we provide an all-order single logarithmic calculation of the primary Lund-plane density in Quantum Chromodynamics, including contributions from the running of the coupling, collinear effects for the leading parton, and soft logarithms that account for large-angle and clustering effects. We also identify a new source of clustering logarithms close to the boundary of the jet, deferring their resummation to future work. We then match our all-order results to exact next-to-leading order predictions. For phenomenological applications, we supplement our perturbative calculation with a Monte Carlo estimate of non-perturbative corrections. The precision of our final predictions for the Lund-plane density is 5−7% at high transverse momenta, worsening to about 20% at the lower edge of the perturbative region, corresponding to transverse momenta of about 5 GeV. We compare our results to a recent measurement by the ATLAS collaboration at the Large-Hadron Collider, revealing good agreement across the perturbative domain, i.e. down to about 5 GeV.
Causality and stability in relativistic viscous non-resistive magneto-fluid dynamics
Authors: Biswas Rajesh , Dash Ashutosh , Haque Najmul , Pu Shi , Roy Victor 
Published: October 2020

Abstract
We investigate the causality and the stability of the relativistic viscous non-resistive magneto-hydrodynamics in the framework of the Israel-Stewart (IS) second-order theory, and also within a modified IS theory which incorporates the effect of magnetic fields in the relaxation equations of the viscous stress. We compute the dispersion relation by perturbing the fluid variables around their equilibrium values. In the ideal magnetohydrodynamics limit, the linear dispersion relation yields the well-known propagating modes: the Alfvén and the magneto-sonic modes. In the presence of bulk viscous pressure, the causality bound is found to be independent of the magnitude of the magnetic field. The same bound also remains true, when we take the full non-linear form of the equation using the method of characteristics. In the presence of shear viscous pressure, the causality bound is independent of the magnitude of the magnetic field for the two magneto-sonic modes. The causality bound for the shear-Alfvén modes, however, depends both on the magnitude and the direction of the propagation. For modified IS theory in the presence of shear viscosity, new non-hydrodynamic modes emerge but the asymptotic causality condition is the same as that of IS. In summary, although the magnetic field does influence the wave propagation in the fluid, the study of the stability and asymptotic causality conditions in the fluid rest frame shows that the fluid remains stable and causal given that they obey certain asymptotic causality condition.
A more natural composite Higgs model
Authors: Cheng Hsin-Chia , Chung Yi 
Published: October 2020

Abstract
Composite Higgs models provide an attractive solution to the hierarchy problem. However, many realistic models suffer from tuning problems in the Higgs potential. There are often large contributions from the UV dynamics of the composite resonances to the Higgs potential, and tuning between the quadratic term and the quartic term is required to separate the electroweak breaking scale and the compositeness scale. We consider a composite Higgs model based on the SU(6)/Sp(6) coset, where an enhanced symmetry on the fermion resonances can minimize the Higgs quadratic term. Moreover, a Higgs quartic term from the collective symmetry breaking of the little Higgs mechanism can be realized by the partial compositeness couplings between elementary Standard Model fermions and the composite operators, without introducing new elementary fields beyond the Standard Model and the composite sector. The model contains two Higgs doublets, as well as several additional pseudo-Nambu-Goldstone bosons. To avoid tuning, the extra Higgs bosons are expected to be relatively light and may be probed in the future LHC runs. The deviations of the Higgs couplings and the weak gauge boson couplings also provide important tests as they are expected to be close to the current limits in this model.
Reggeon field theory and self duality: making ends meet
Authors: Kovner Alex , Levin Eugene , Li Ming , Lublinsky Michael 
Published: October 2020

Abstract
Motivated by the question of unitarity of Reggeon Field Theory, we use the effective field theory philosophy to find possible Reggeon Field Theory Hamiltonians HRFT. We require that HRFT is self dual, reproduce all known limits (dilute-dense and dilute-dilute) and exhibits all the symmetries of the JIMWLK Hamiltonian. We find a family of Hamiltonians which satisfy all the above requirements. One of these is identical in form to the so called “diamond action” discussed in [67, 68]. However we show by explicit calculation that the so called “diamond condition” is not satisfied beyond leading perturbative order.