bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiated Integration and Disintegration in the EU: Brexit, the Eurozone Crisis, and Other Troubles
Authors: Markakis Menelaos 
Published: March 2020

Abstract
This article looks at theories of differentiated integration and disintegration in the wake of the Eurozone crisis and the Brexit referendum. It advances four distinct, albeit interrelated, arguments with respect to these proposals. First, it could be contested whether certain policy areas should be pushed to the ‘outer core’ of European integration. Second, it would be very difficult to disentangle those areas to be pushed to the ‘outer core’ from those areas remaining in the ‘inner core’. Third, the legal and institutional arrangements for organizing differentiated integration are equally important. Fourth, even if the problems adumbrated above could be addressed satisfactorily, the emerging arrangements for differentiated integration would differ little from the degree of flexibility or variation that already exists within some of those areas. Brexit may be viewed as an opportunity for reform to ‘fix’ those issues that are regarded as problematic in the design or functioning of the EU. Should it appear desirable to pursue differentiated integration, the better course of action would be to build on those opportunities for differentiated integration that are offered by the EU Treaties. Any forthcoming Treaty revision to take stock of Brexit could be used to give added impetus to differentiated integration.
Cn algebras with Moisil possibility operators
Authors: Figallo Aldo V , Pelaitay Gustavo , Sarmiento Jonathan 
Published: March 2020

Abstract
In this paper, we continue the study of the Łukasiewicz residuation algebras of order $n$ with Moisil possibility operators (or $MC_n$-algebras) initiated by Figallo (1989, PhD Thesis, Universidad Nacional del Sur). More precisely, among other things, a method to determine the number of elements of the $MC_n$-algebra with a finite set of free generators is described. Applying this method, we find again the results obtained by Iturrioz and Monteiro (1966, Rev. Union Mat. Argent., 22, 146) and by Figallo (1990, Rep. Math. Logic, 24, 3–16) for the case of Tarski algebras and $I\varDelta _{3}$-algebras, respectively.
Novel Characteristics of Immune Responsive Protein IRP30 in the Bumble Bee Bombus lantschouensis (Hymenoptera: Apidae)
Authors: Dong Jie , Wu Jie , Han Lei , Huang Jiaxing , Wang Deqian 
Published: March 2020

AbstractImmune responsive protein 30 (IRP30) is a Hymenoptera-specific protein first identified from honey bee hemolymph in response to bacterial infection. However, its function remains elusive. Here, we cloned the full-length IRP30 gene and clarified its expression pattern in the bumble bee Bombus lantschouensis (Vogt). The full-length IRP30 gene measures 1443 bp and contains two exons and one intron. The length of the cDNA is 1082 bp, including a 36-bp 5′-UTR and a 218-bp 3′-UTR, and it encodes a putative protein of 275 amino acids. As expected, the sequence of the B. lantschouensis IRP30 protein was clustered with the bumble bee group, which appeared as a single clade next to honey bees. The family shared similar conserved protein domains. Moreover, bumble bee IRP30 belongs to a recently diverged clade that has four leucine-rich repeat (LRR) conserved domains. IRP30 is highly expressed in the worker caste, during pupal developmental stages, and in the head and thorax tissues. Interestingly, its expression increases 20- to 90-fold when female bumble bees (B. lantschouensis) and honey bees (Apis mellifera L.) begin laying eggs. Overall, based on the expression of IRP30 during development and egg laying in female bumble bees, this protein not only responds to immune challenge but also may play an important role in metamorphosis and reproduction.
Snowshoe hare feeding behavior responds to coyote and moose cues at diverse vegetation densities
Authors: Lankist Zachary K , Maher Christine R 
Published: March 2020

Abstract
Heterospecific competitors can use chemical cues left by dominant species to avoid aggressive interactions. Similarly, prey avoid chemical cues from predators at feeding sites, presumably because risk of death outweighs the benefit of food. This study addressed the lack of information regarding mammals’ avoidance of direct cues from competitors and also examined how indirect cues, i.e., vegetative cover, affect foraging behavior. To test if chemical cues and vegetative cover alter the number of visits by prey species and time spent at feeding plots, we observed snowshoe hares (Lepus americanus) in plots containing coyote (Canis latrans; predator) and moose (Alces alces; competitor) urine across a spectrum of vegetation densities. Snowshoe hares significantly reduced number of visits to plots that contained coyote or moose urine. In plots treated with coyote urine, number of visits decreased significantly as plots became more densely vegetated. Neither chemical cues nor vegetation density affected time spent in plots. These results suggest that competition between snowshoe hares and moose has selected for an avoidance response. This study also reinforces the idea that an increase in vegetation density could prove disadvantageous to prey, perhaps because some predators use dense vegetation to their advantage.
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis
Authors: Ikenaka Kensuke , Ishigaki Shinsuke , Iguchi Yohei , Kawai Kaori , Fujioka Yusuke , Yokoi Satoshi , Abdelhamid Rehab F , Nagano Seiichi , Mochizuki Hideki , Katsuno Masahisa , Sobue Gen 
Published: March 2020

Abstract
Alterations of RNA metabolism caused by mutations in RNA-binding protein genes, such as transactivating DNA-binding protein-43 (TDP-43) and fused in sarcoma (FUS), have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Unlike the accumulation of TDP43, which is accepted as a pathological hall mark of sporadic ALS (sALS), FUS pathology in sALS is still under debate. Although immunoreactive inclusions of FUS have been detected in sALS patients previously, the technical limitation of signal detection, including the necessity of specific antigen retrieval, restricts our understanding of FUS-associated ALS pathology. In this study, we applied a novel detection method using a conventional antigen retrieval technique with Sudan Black B treatment to identify FUS-positive inclusions in sALS patients. We classified pathological motor neurons into 5 different categories according to the different aggregation characteristics of FUS and TDP-43. Although the granular type was more dominant for inclusions with TDP-43, the skein-like type was more often observed in FUS-positive inclusions, suggesting that these 2 proteins undergo independent aggregation processes. Moreover, neurons harboring FUS-positive inclusions demonstrated substantially reduced expression levels of dynactin-1, a retrograde motor protein, indicating that perturbation of nucleocytoplasmic transport is associated with the formation of cytoplasmic inclusions of FUS in sALS.
Efficacy of radiation boost after breast-conserving surgery for breast cancer with focally positive, tumor-exposed margins
Authors: Suzuki Ryoko , Yoshida Masahiro , Oguchi Masahiko , Yoshioka Yasuo , Tokumasu Kenji , Osako Tomo , Ono Shinji , Ueno Takayuki , Miyagi Yumi 
Published: March 2020

Abstract
Many patients with positive margins following breast-conserving surgery (BCS) undergo re-excisions that aim to remove residual disease from the breast, which brings a tremendous emotional burden in addition to financial consequences. We sought to determine whether re-excisions could be safely avoided without compromising local control and survival by using whole-breast radiation therapy (WBRT) with a tumor bed boost in patients with early-stage breast cancer with focally positive, tumor-exposed margins after BCS. All patients with ductal carcinoma in situ (DCIS) and/or invasive breast cancer (IBC) who had pathologically tumor-exposed margins following BCS, without re-excision and treated with WBRT with tumor bed boost between March 2005 and December 2011, were included. The radiotherapy consisted of WBRT at a dose of 50 Gy in 25 fractions, followed by a tumor bed boost with an additional dose of 16 Gy in eight fractions. A total of 125 patients fulfilled the eligibility criteria; of the 125 patients, 1 had bilateral breast cancer, resulting in 126 cases. Invasive disease was found in 102 (81%) cases and purely ductal carcinoma in situ (DCIS) disease in 24 (19%) cases. The 10-year ipsilateral breast tumor recurrence (IBTR) -free survival, progression-free survival (PFS), and 10-year overall survival (OS) rates were 95%, 92.5% and 96%, respectively. Patients with early-stage breast cancer who receive BCS and have focally positive, tumor-exposed margins can avoid re-excision by undergoing WBRT followed by a sufficient dose of tumor bed boost, without negatively impacting local control and survival.
Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts
Authors: Behmand B , Noronha A M , Wilds C J , Marignier J-L , Mostafavi M , Wagner J R , Hunting D J , Sanche L 
Published: March 2020

Abstract
Double-stranded oligonucleotides containing cisplatin adducts, with and without a mismatched region, were exposed to hydrated electrons generated by gamma-rays. Gel electrophoresis analysis demonstrates the formation of cisplatin-interstrand crosslinks from the cisplatin-intrastrand species. The rate constant per base for the reaction between hydrated electrons and the double-stranded oligonucleotides with and without cisplatin containing a mismatched region was determined by pulse radiolysis to be 7 × 109 and 2 × 109 M−1 s−1, respectively. These results provide a better understanding of the radiosensitizing effect of cisplatin adducts in hypoxic tumors and of the formation of interstrand crosslinks, which are difficult for cells to repair.
Silent burn: the hidden danger and effects of bright light from fibre-optic cables in arthroscopic knee surgery
Authors: Chitnavis Jai 
Published: March 2020

Abstract

Following an uneventful arthroscopic menisectomy of the right knee, a white circular skin lesion, 1 cm in diameter, was noted on the anterior left thigh of a 23-year-old patient. The overlying paper surgical drape had not ignited nor produced smoke. Close inspection revealed a minute perforation in the drape with slight discolouration. No electro-cautery, radio-ablation or irritant skin preparation had been used during surgery. Tests failed to identify fault with the light source, fibre-optic cable or arthroscope.

The lesion was diagnosed as a full-thickness thermal burn resulting from heat transmitted from a 300-W Xenon lamp via a detached fibre-optic cable. The effects of contact between an illuminated fibre-optic light cable and living human skin are described, with changes in appearances followed over 2 years. Patients may be burnt and permanently scarred without the knowledge of staff in operating theatres if detached light cables rest against surgical drapes.
Seasonal nitrogen remobilization and the role of auxin transport in poplar trees
Authors: Li Gen , Lin Rongshoung , Egekwu Chioma , Blakeslee Joshua , Lin Jinshan , Pettengill Emily , Murphy Angus S , Peer Wendy A , Islam Nazrul , Babst Benjamin A , Gao Fei , Komarov Sergey , Tai Yuan-Chuan , Coleman Gary D 
Published: March 2020

Abstract
Seasonal nitrogen (N) cycling in Populus, involves bark storage proteins (BSPs) that accumulate in bark phloem parenchyma in the autumn and decline when shoot growth resumes in the spring. Little is known about the contribution of BSPs to growth or the signals regulating N remobilization from BSPs. Knockdown of BSP accumulation via RNAi and N sink manipulations were used to understand how BSP storage influences shoot growth. Reduced accumulation of BSPs delayed bud break and reduced shoot growth following dormancy. Further, 13N tracer studies also showed that BSP accumulation is an important factor in N partitioning from senescing leaves to bark. Thus, BSP accumulation has a role in N remobilization during N partitioning both from senescing leaves to bark and from bark to expanding shoots once growth commences following dormancy. The bark transcriptome during BSP catabolism and N remobilization was enriched in genes associated with auxin transport and signaling, and manipulation of the source of auxin or auxin transport revealed a role for auxin in regulating BSP catabolism and N remobilization. Therefore, N remobilization appears to be regulated by auxin produced in expanding buds and shoots that is transported to bark where it regulates protease gene expression and BSP catabolism.
Can we detect the stellar differential rotation of WASP-7 through the Rossiter–McLaughlin observations?
Authors: Serrano L M , Oshagh M , Cegla H M , Barros S C C , Santos N C , Faria J P , Akinsanmi B 
Published: March 2020

ABSTRACT
The Rossiter–McLaughlin (RM) effect is the radial velocity signal generated when an object transits a rotating star. Stars rotate differentially and this affects the shape and amplitude of this signal, on a level that can no longer be ignored with precise spectrographs. Highly misaligned planets provide a unique opportunity to probe stellar differential rotation via the RM effect, as they cross several stellar latitudes. In this sense, WASP-7, and its hot Jupiter with a projected misalignment of ∼90°, is one of the most promising targets. The aim of this work is to understand if the stellar differential rotation is measurable through the RM signal for systems with a geometry similar to WASP-7. In this sense, we use a modified version of soap3.0 to explore the main hurdles that prevented the precise determination of the differential rotation of WASP-7. We also investigate whether the adoption of the next generation spectrographs, like ESPRESSO, would solve these issues. Additionally, we assess how instrumental and stellar noise influence this effect and the derived geometry of the system. We found that, for WASP-7, the white noise represents an important hurdle in the detection of the stellar differential rotation, and that a precision of at least 2 m s−1 or better is essential.
HST/WFC3 grism observations of z ∼ 1 clusters: evidence for evolution in the mass–size relation of quiescent galaxies from post-starburst galaxies
Authors: Matharu J , Muzzin A , Brammer G B , van der Burg R F J , Auger M W , Hewett P C , Chan J C C , Demarco R , van Dokkum P , Marchesini D , Nelson E J , Noble A G , Wilson G 
Published: March 2020

ABSTRACT
Minor mergers have been proposed as the driving mechanism for the size growth of quiescent galaxies with decreasing redshift. The process whereby large star-forming galaxies quench and join the quiescent population at the large size end has also been suggested as an explanation for this size growth. Given the clear association of quenching with clusters, we explore this mechanism by studying the structural properties of 23 spectroscopically identified recently quenched (or ‘post-starburst’ (PSB)) cluster galaxies at z ∼ 1. Despite clear PSB spectral signatures implying rapid and violent quenching, 87 per cent of these galaxies have symmetric, undisturbed morphologies in the stellar continuum. Remarkably, they follow a mass–size relation lying midway between the star-forming and quiescent field relations, with sizes 0.1 dex smaller than z ∼ 1 star-forming galaxies at log(M*/M⊙) = 10.5. This implies a rapid change in the light profile without directly effecting the stellar distribution, suggesting changes in the mass-to-light ratio gradients across the galaxy are responsible. We develop fading toy models to explore how star-forming galaxies move across the mass–size plane as their stellar populations fade to match those of the PSBs. ‘Outside-in’ fading has the potential to reproduce the contraction in size and increase in bulge-dominance observed between star-forming and PSB cluster galaxies. Since cluster PSBs lie on the large size end of the quiescent mass–size relation, and our previous work shows cluster galaxies are smaller than field galaxies, the sizes of quiescent galaxies must grow both from the quenching of star-forming galaxies and dry minor mergers.
Parameters of dust jets in comet Encke’s coma
Authors: Chernetenko Yu , Medvedev Yu 
Published: March 2020

ABSTRACTUsing 4412 positional observations, we compute eight single apparition orbits in the period 1993–2017. The analysis of the residuals of the orbit’s fit shows their systematic deviations around perihelia. We assume that these deviations in positional observations are a result of the dust emissions from a restricted area of the nucleus, and that the ejected dust particles contain a certain amount of ice. Additional sublimation of ice from particles causes a gas-rich effect when the comet is approaching the Sun. Another effect of the jet motion of particles is a shift of the centre of brightness in the direction of ejection. Taking these effects into account, we estimate the size of the dust particles (2–10 cm) containing $80{{\ \rm per\ cent}}$ ice, dust velocities (1.8–2.6 m s−1), and the positions of active regions on the comet’s nucleus (cometocentric latitude from 55° to 74°). These estimates are based on the data for the residuals in the positional observations before the perihelia of the 1993, 2003, 2013 and 2017 apparitions.
Energy optimization in extrasolar planetary systems: the transition from peas-in-a-pod to runaway growth
Authors: Adams Fred C , Batygin Konstantin , Bloch Anthony M , Laughlin Gregory 
Published: March 2020

ABSTRACT
Motivated by the trends found in the observed sample of extrasolar planets, this paper determines tidal equilibrium states for forming planetary systems – subject to conservation of angular momentum, constant total mass, and fixed orbital spacing. In the low mass limit, valid for super-Earth-class planets with masses of order mp ∼ 10 M⊕, previous work showed that energy optimization leads to nearly equal mass planets, with circular orbits confined to a plane. The present treatment generalizes previous results by including the self-gravity of the planetary bodies. For systems with a sufficiently large total mass $m_{\scriptstyle \rm T}$ in planets, the optimized energy state switches over from the case of nearly equal mass planets to a configuration where one planet contains most of the material. This transition occurs for a critical mass threshold of approximately $m_{\scriptstyle \rm T}\gtrsim m_{\scriptstyle \rm C}\sim 40\,{\rm M_\oplus}$ (where the value depends on the semimajor axes of the planetary orbits, the stellar mass, and other system properties). These considerations of energy optimization apply over a wide range of mass scales, from binary stars to planetary systems to the collection of moons orbiting the giant planets in our Solar system.
Two-temperature magnetohydrodynamic simulations for sub-relativistic active galactic nucleus jets: dependence on the fraction of the electron heating
Authors: Ohmura Takumi , Machida Mami , Nakamura Kenji , Kudoh Yuki , Matsumoto Ryoji 
Published: March 2020

ABSTRACT
We present the results of two-temperature magnetohydrodynamic simulations of the propagation of sub-relativistic jets of active galactic nuclei. The dependence of the electron and ion temperature distributions on the fraction of electron heating, fe, at the shock front is studied for fe = 0, 0.05, and 0.2. Numerical results indicate that in sub-relativistic, rarefied jets, the jet plasma crossing the terminal shock forms a hot, two-temperature plasma in which the ion temperature is higher than the electron temperature. The two-temperature plasma expands and forms a backflow referred to as a cocoon, in which the ion temperature remains higher than the electron temperature for longer than 100 Myr. Electrons in the cocoon are continuously heated by ions through Coulomb collisions, and the electron temperature thus remains at Te &gt; 109 K in the cocoon. X-ray emissions from the cocoon are weak because the electron number density is low. Meanwhile, X-rays are emitted from the shocked intracluster medium (ICM) surrounding the cocoon. Mixing of the jet plasma and the shocked ICM through the Kelvin–Helmholtz instability at the interface enhances X-ray emissions around the contact discontinuity between the cocoon and shocked ICM.
Chemical evolution of galaxies: emerging dust and the different gas phases in a new multiphase code
Authors: Millán-Irigoyen I , Mollá M , Ascasibar Y 
Published: March 2020

ABSTRACT
Dust plays an important role in the evolution of a galaxy, as it is one of the main ingredients for efficient star formation. Dust grains are also a sink/source of metals when they are created/destroyed, and, therefore, a self-consistent treatment is key in order to correctly model chemical evolution. In this work, we discuss the implementation of dust physics in our current multiphase model, which also follows the evolution of atomic, ionized and molecular gas. Our goal is to model the conversion rates among the different phases of the interstellar medium, including the creation, growth and destruction of dust, based, as far as possible, on physical principles rather than on phenomenological recipes. We first present the updated set of differential equations and then discuss the results. We calibrate our model against observations of the Milky Way Galaxy and compare its predictions with extant data. Our results are broadly consistent with the observed data for intermediate and high metallicities, but the models tend to produce more dust than is observed in the low-metallicity regime.
Physical conditions in two high-redshift H2-bearing GRB-DLAs, 120815A and 121024A
Authors: Shaw Gargi , Ferland G J 
Published: March 2020

ABSTRACT
The gamma-ray burst (GRB) afterglows provide a unique opportunity to study the interstellar medium (ISM) of star-forming galaxies at high-redshift. The GRB-DLAs (damped Lyman-α absorbers) contain a large neutral hydrogen column density, N(H i), and are observed against the GRB afterglow. A large fraction of GRB-DLAs show presence of molecular hydrogen (H2) which is an indicator of star-formation. Hence it is important to study those GRB-DLAs which have H2 lines to decipher and understand their physical conditions. The GRB-DLAs 121024A and 120815A, situated at redshift 2.30 and 2.36, respectively, are two such important H2-bearing GRB-DLAs. Besides H2, these two GRB-DLAs also show many metal lines. In this work we have carried out a detail numerical study on the H2 lines, as well as on those metal lines, in GRB-DLAs 121024A and 120815A self-consistently. We use the spectral synthesis code cloudy for this study. This modelling helps us to determine the underlying physical conditions which give rise to such lines and hence to understand these two GRB-DLAs in much more detail than any other previous investigation. We find that the hydrogen densities for these two H2-bearing DLAs are ≥60 cm−3. Moreover our study infers that the linear sizes are ≤17.7 pc for these two GRB-DLAs, and the mean gas temperatures averaged over the cloud thickness, are ≤140 K. Overall, we find that these two H2-bearing GRB-DLAs are denser, cooler, and smaller compared to those without H2.