bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROLE OF PHYSIOTHERAPY IN COVID-19 PATIENTS
Authors: Diwate Abhijit 
Published: August 2020

Corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 is a new corona virus that was first identified in Wuhan city of China in December 2019. In the wake of COVID 19 affecting India, the worst affected is the state of Maharashtra accounting for one third of all cases in the country. Physiotherapy is beneficial in the treatment and physical rehabilitation of patients with COVID-19. Patient presenting with productive cough and with underlying respiratory conditions benefit from the Physiotherapy. “Expert consensus and recommendation for Physiotherapy management for COVID 19 in Indian set up” guidelines approved by Maharashtra State Council for Occupational Therapy and Physiotherapy, Mumbai will help physiotherapists in decision making and treatment planning.
Simultaneous measurements of urban and rural particles in Beijing – Part 1: Chemical composition and mixing state
Authors: Chen Yang , Cai Jing , Wang Zhichao , Peng Chao , Yao Xiaojiang , Tian Mi , Han Yiqun , Shi Guangming , Shi Zongbo , Liu Yue , Yang Xi , Zheng Mei , Zhu Tong , He Kebin , Zhang Qiang , Yang Fumo 
Published: August 2020

Abstract. Two single-particle aerosol mass spectrometers (SPAMSs) were deployed
simultaneously at an urban and a rural site in Beijing during an intensive
field campaign from 1 to 29 November 2016 to investigate the source
and process of airborne particles in Beijing. In the first part of this
research, we report the single-particle chemical composition, mixing state,
and evolution at both sites. A total of 96 % and 98 % of collected particles were
carbonaceous at the urban and rural sites, respectively. Five particle
categories, including elemental carbon (EC), organic carbon (OC),
internal-mixed EC and OC (ECOC), potassium-rich (K-rich), and metals, were
observed at both sites. The categories were partitioned into particle types
depending on different atmospheric processing stages. A total of 17 particle types were shared at both sites. In the urban area, nitrate-containing
particle types, such as EC-Nit (Nit: nitrate) and ECOC-Nit, were enriched especially at
night, sulfate-containing particles were transported when wind speed was
high, and ECOC-Nit-Sul (Sul: sulfate) were mostly aged locally. In sum, these processed particles
added up to 85.3 % in the urban areas. In the rural area, regional
particles were abundant, but freshly emitted ECOC and OC had distinct
patterns that were pronounced at cooking and heating times. Biomass burning,
traffic, and coal burning were major sources of particulate matter (PM2.5) in both rural and urban areas. Moreover, particles from the steel industry located in the
south were also identified. In summary, the chemical composition of urban
and rural particle types was similar in Beijing; the urban particles were
influenced significantly by rural processing and transport. The work is
useful to understand the evolution of urban and rural particles in Beijing
during winter.
A global monthly climatology of oceanic total dissolved inorganic carbon: a neural network approach
Authors: Broullón Daniel , Pérez Fiz F. , Velo Antón , Hoppema Mario , Olsen Are , Takahashi Taro , Key Robert M. , Tanhua Toste , Santana-Casiano J. Magdalena , Kozyr Alex 
Published: August 2020

Abstract. Anthropogenic emissions of CO2 to the atmosphere have
modified the carbon cycle for more than 2 centuries. As the ocean
stores most of the carbon on our planet, there is an important task in
unraveling the natural and anthropogenic processes that drive the
carbon cycle at different spatial and temporal scales. We contribute
to this by designing a global monthly climatology of total dissolved
inorganic carbon (TCO2), which offers a robust basis in
carbon cycle modeling but also for other studies related to this
cycle. A feedforward neural network (dubbed NNGv2LDEO) was configured
to extract from the Global Ocean Data Analysis Project version 2.2019
(GLODAPv2.2019) and the Lamont–Doherty Earth Observatory (LDEO) datasets the relations between TCO2 and a set of variables
related to the former's variability. The global root mean square
error (RMSE) of mapping TCO2 is relatively low for the two
datasets (GLODAPv2.2019: 7.2 µmol kg−1; LDEO:
11.4 µmol kg−1) and also for independent data,
suggesting that the network does not overfit possible errors in
data. The ability of NNGv2LDEO to capture the monthly variability of
TCO2 was testified through the good reproduction of the
seasonal cycle in 10 time series stations spread over different
regions of the ocean (RMSE: 3.6 to
13.2 µmol kg−1). The climatology was obtained by
passing through NNGv2LDEO the monthly climatological fields of
temperature, salinity, and oxygen from the World Ocean Atlas 2013 and
phosphate, nitrate, and silicate computed from a neural network fed
with the previous fields. The resolution is 1∘×1∘ in
the horizontal, 102 depth levels (0–5500 m), and monthly
(0–1500 m) to annual (1550–5500 m) temporal resolution, and it is
centered around the year 1995. The uncertainty of the climatology is low
when compared with climatological values derived from measured
TCO2 in the largest time series stations. Furthermore, a
computed climatology of partial pressure of CO2
(pCO2) from a previous climatology of total alkalinity and
the present one of TCO2 supports the robustness of this
product through the good correlation with a widely used pCO2
climatology (Landschützer et al., 2017). Our TCO2
climatology is distributed through the data repository of the Spanish
National Research Council (CSIC; https://doi.org/10.20350/digitalCSIC/10551,
Broullón et al., 2020).
Artificially Intelligent Sexbots and Sexual Solipsism—A Posthumanist Ethical Approach
Authors: Schussler Aura-Elena 
Published: August 2020

ABSTRACT
This article aims to question—from the perspective of posthumanist theories—the normativity of human sexuality, located at the borderline between the technological imminence of AI sexbots and the humanistic legacy of Western socio-cultural constructions, governed by masculine bias. The purpose is to emphasize that as long as this normativity remains encapsulated within the boundaries of the culture of Western metaphysics—characterized by the anthropocentrist, dualist, and speciesist paradigm—the sexual domain will permanently constitute an antagonistic ground of discrimination and binary hierarchical relations, an aspect that will permanently attract the possibility of manifesting sexual solipsism. The general objective follows the paradigm shifts that this hypothesis of sex with weak/strong AI sexbots can bring about on an ethical level, along with the risks/benefits that may appear on the social level. The theoretical objective consists of a posthumanist analysis of the phenomenon of weak/strong AI sexbots, which calls into question both the ontology of the person and Rae Langton’s sexual solipsism theory—specific to the humancentric paradigm. The methodology used is that of the critics/arguments brought from the perspective of posthumanist philosophy (Rosi Braidotti, Francesca Ferrando), supplemented by the deconstructivist philosophy of Gilles Deleuze, in the direction of arguing for a postdualistic rhizomatic sexuality, which upholds an ethic of diversity and of continuous becoming within the limits of an emergent ontology of differences.
Interpreting Posthumanism with Nurse Work
Authors: Smith Jamie B. , Willis Eva 
Published: August 2020

ABSTRACTThe scarcity of research into care work shows that it is still unclear “what constitutes the discrete fundamentals of care.” It is this invisibility of care in the time of posthuman convergence in which we find ourselves. In this article we argue that care work (understood in this article through nursing) and posthumanism illuminate human and more-than-human world making. Practical experiences of nursing can help us understand world making with posthuman philosophies and knowledge production, while the critical theories of posthumanism can point us to a humanistic understanding of care work. Posthumanism challenges commonplace assumptions of concepts from which we frame our everyday lives. We show nurse work through a posthuman lens and begin to demonstrate opportunities to make posthumanism perceptible. In approaching nursing from this perspective, we then suggest new possibilities for approaching nurse work and care.
A prognostic gene model of immune cell infiltration in diffuse large B-cell lymphoma
Authors: Zhou Hao , Zheng Chang , Huang De-Sheng 
Published: August 2020

Background
Immune cells in the tumor microenvironment are an important prognostic indicator in diffuse large B-cell lymphoma (DLBCL). However, information on the heterogeneity and risk stratification of these cells is limited. We sought to develop a novel immune model to evaluate the prognostic intra-tumoral immune landscape of patients with DLBCL.

Methods
The ESTIMATE and CIBERSORT algorithms were used to estimate the numbers of 22 infiltrating immune cells based on the gene expression profiles of 229 patients with DLBCL who were recruited from a public database. The least absolute shrinkage and selection operator (Lasso) penalized regression analyses and nomogram model were used to construct and evaluate the prognostic immunoscore (PIS) model for overall survival prediction. An immune gene prognostic score (IGPS) was generated by Gene Set Enrichment Analysis (GSEA) and Cox regression analysis was and validated in an independent NCBI GEO dataset (GSE10846).

Results
A higher proportion of activated natural killer cells was associated with a poor outcome. A total of five immune cells were selected in the Lasso model and DLBCL patients with high PIS showed a poor prognosis (hazard ratio (HR) 2.16; 95% CI [1.33–3.50]; P = 0.002). Differences in immunoscores and their related outcomes were attributed to eight specific immune genes involved in the cytokine–cytokine receptor interaction and chemokine signaling pathways. The IGPS based on a weighted formula of eight genes is an independent prognostic factor (HR: 2.14, 95% CI [1.40–3.28]), with high specificity and sensitivity in the validation dataset.

Conclusions
Our findings showed that a PIS model based on immune cells is associated with the prognosis of DLBCL. We developed a novel immune-related gene-signature model associated with the PIS model and enhanced the prognostic functionality for the prediction of overall survival in patients with DLBCL.
Medial knee cartilage is unlikely to withstand a lifetime of running without positive adaptation: a theoretical biomechanical model of failure phenomena
Authors: Miller Ross H. , Krupenevich Rebecca L. 
Published: August 2020

Runners on average do not have a high risk of developing knee osteoarthritis, even though running places very high loads on the knee joint. Here we used gait analysis, musculoskeletal modeling, and a discrete-element model of knee contact mechanics to estimate strains of the medial knee cartilage in walking and running in 22 young adults (age 23 ± 3 years). A phenomenological model of cartilage damage, repair, and adaptation in response to these strains then estimated the failure probability of the medial knee cartilage over an adult lifespan (age 23–83 years) for 6 km/day of walking vs. walking and running 3 km/day each. With no running, by age 55 the cumulative probability of medial knee cartilage failure averaged 36% without repair and 13% with repair, similar to reports on incidence of knee osteoarthritis in non-obese adults with no knee injuries, but the probability for running was very high without repair or adaptation (98%) and remained high after including repair (95%). Adaptation of the cartilage compressive modulus, cartilage thickness, and the tibiofemoral bone congruence in response to running (+1.15 standard deviations of their baseline values) was necessary for the failure probability of walking and running 3 km/day each to equal the failure probability of walking 6 km/day. The model results suggest two conclusions for further testing: (i) unlike previous findings on the load per unit distance, damage per unit distance on the medial knee cartilage is greater in running vs. walking, refuting the “cumulative load” hypothesis for long-term joint health; (ii) medial knee cartilage is unlikely to withstand a lifetime of mechanical loading from running without a natural adaptation process, supporting the “cartilage conditioning” hypothesis for long-term joint health.
Toxicity Assay of Methanolic Extract of Caryota No Seed using Drosophila melanogaster Model
Authors: Maduagwuna Chinonye A. , Omale Simeon , Etuh Monday A. , Gyang Steven S. 
Published: August 2020

Objectives: To investigate the effect of methanolic extract of Caryota no (CN) seeds in Drosophila melanogaster (DM) survival and life span.
Study Design: Experimental design.
Place and Duration: African Centre of Excellence for Phytomedicine Research and Development, University of Jos, Jos Plateau State Nigeria between June 2018 and February 2019.
Methods: The LC50 was determined by exposing 50 flies to concentrations ranging from 1 mg to 600 mg per 10 g diet and mortality of flies was scored every 24 hours for 14 days and from the results, five doses were chosen for the next assay. Survival assays were carried out by exposing 50 flies in each vial to the following concentrations: 300 mg, 350 mg, 400 mg, 500 mg and 600 mg of methanolic extract in 5 replicates for 28 days with daily recording of mortality while the longevity assay continued from the survival until the last fly dies. All three experiments were done as three independent trials.
Results: The LC50 values of the methanolic extract was determined to be 6.533e+017 mg/10g food in D. melanogaster. The result of the survival assay with methanolic extract of CN showed slight significant (P < .05) increase with the lowest two doses but no significant (P > .05) difference with other higher doses compared to the control. The longevity assay revealed that the extract significantly (P < .05) decreased longevity in Drosophila melanogaster.
Conclusion: The results obtained from evaluating the methanolic extract of Caryota no indicate that the plant is relatively non-toxic and maybe safe under acute and subacute exposures but may become deleterious during chronic exposure.
In vivo Antioxidant Effects of Coconut (Cocos nucifera) Water Extract in Wistar Albino Rats
Authors: Mba O. J. , Edward U. I. , Aja O. A. , Atiaetuk I. E. , Ndukwe M. K. 
Published: August 2020

Aim: The present study was designed to investigate the invivo antioxidant effects of coconut (Cocos nucifera) water extract in wistar albino rats.
Methodology: Thirty (30) male wistar albino rats of mean weight 128 g were used for the study. The animals for the study were grouped into five (5) of six (6) rats each. Group 1 served as the normal control group that received feed and water only while groups 2, 3, 4, and 5 served as the test groups that were orally given 10 ml, 20 ml, 30 ml, and 40 ml of the coconut water extract for 28 days. The rats were sacrificed after 28 days and the blood samples were collected for biochemical analysis.
Results: From the result obtained there is a significant increase (p< 0.05) between the normal control group (group 1) and the test group (group 2) that received 20 ml of the coconut water extract for MDA. There is a significant increase (p< 0.05) between the normal control group (group 1) and the test groups (groups 2 and 5) that received 10 ml and 50 ml of the coconut water extract for SOD. Also, there is a significant increase (p< 0.05) between the normal control group (group 1) and the test groups (groups 2, 3 and 4) that received 20 ml, 30 ml and 40 ml of the coconut water extract for Catalase. For GSH and Vitamin C, there is a significant increase (p< 0.05) between the normal control group (group 1) and the test groups (groups 2, 3, 4 and 5) that were orally given 10 ml, 20 ml, 30 ml and 40 ml of the coconut water extract.
Conclusion: The present investigation showed that the coconut water extract increased antioxidant properties in wistar albino rats and may also be used pharmacologically in the treatment of diseases implicated by free radicals.
In silico Anti-malaria Activity of Quinolone Compounds against Plasmodium falciparum Dihydrofolate Reductase (pfDHFR)
Authors: Balogun Toheeb A. , Omoboyowa Damilola A. , Saibu Oluwatosin A. 
Published: August 2020

Chemotherapy remains the kernel of malaria control and the available antimalarial drugs are not only expensive but also parade heterogeneous levels of toxicity and may invoke poor compliance in patients. The present study focuses on the screening of quinolone compounds against Plasmodium falciparum dihydrofolate reductase (pfDHFR) for anti-malarial potential using Glide (Schrodinger maestro 2017-1). Computational tool using Glide was employed to investigate the therapeutic relevance of six (6) quinolone derivatives retrieved from PUBCHEM via molecular docking against pfDHFR retrieved from protein data base. The results showed that, Lascufloxacin and moxifloxacin bind with higher affinity and lower free energy with catalytic domain of pfDHFR with glide score of -6.597 and -5.653 respectively compared to standard ligand (quinine) with glide score of -3.728. Lascufloxacin interacted with amino acid residue of the catalytic domain (SER 511, ARG 510, GLU 382) as evaluated by energy decomposition per residue lascufloxacin-pfDHFRcomplex. The results from this investigation, thus proposed quinolone derivatives as hit lead drug candidates which may be consider as potential inhibitor of pfDHFR.
Changes in Chlorophyll and Protein Contents of Vigna unguiculata, Glycine max, Zea mays and Sorghum bicolor Raised in Soil Incorporated with the Shoots of Tithonia rotundifolia
Authors: Ilori O. J. , Otusanya O. O. 
Published: August 2020

Tithonia. rotundifolia is an allelopathic weed that grows in association with cultivated crops in Nigeria. Allelopathy is a phenomenon of plant releasing allelochemicals into the environment that can inhibit or stimulate the growth of other plants and microorganisms. This study aimed to evaluate the effects of soil incorporated with the fresh shoots of T. rotundifolia on chlorophyll and protein accumulation of Vigna unguiculata L. Glycine max L., Zea mays L. and Sorghum bicolor L. 250 g of fresh shoots of T. rotundifolia were worked into each plot of 2 m2 dimension and the test crops were sown in the plots. Plots with no T. rotundifolia shoots were included as control plots. The experiment was performed in completely randomized block design (CRBD). The parameters measured were chlorophyll a, chlorophyll b total chlorophyll and protein content. The results showed a stimulation in chlorophyll contents in the test crops except inhibition in chl b and total chlorophyll in Zea mays L. Also, there was a stimulation of protein in Zea mays L. and Sorghum bicolor L. The study suggests that incorporation of shoots of Tithonia rotundifolia could imparts stimulatory allelopathic effects.
Intersubjectivity and Food Purchasing: Modeling the Intent to Buy
Authors: Alekhine Philippe Fauquet- , Pavlovskaia Elena Fauquet-Alekhine- , Erskine James A. K. 
Published: August 2020

Aims: A previous study showed that Intersubjectivity Theory could explain how consumers could appreciate a food product when looking at the packaging and reading the brand. Two samples of subjects, English and French consumers, were individually presented first with a foreign language food product and then with a native language food product. Their reaction and perception were analyzed in the light of Intersubjectivity theory.
However, the main limitation of the previous study addressed the psychosocial value carried by the foreign products: the product presented to French subjects had a sexual connotation and not this for the English. The present study intended to analyze this potential bias.
Study Design: For the present study, a new sample of English subjects were individually presented with a foreign language food product having a sexual connotation. Reactions and perceptions were analyzed applying the protocol of the previous study and results were compared in order to analyze the aforementioned potential bias.
Place and Duration of Study: Subjects were individually met in London in 2019 for the experiment.
Methodology: Subjects were selected as in the previous study: volunteer, healthy adults, native English language (N=20, 60% male, average age: 35 years old, middle class). Their spontaneous reaction was observed and they had to fill in the questionnaire addressing intersubjective perspectives regarding the product. Answers were ticked on a Likert scale and data were compared with that of the previous study.
Results: The results confirmed the previous study: the comparison of the percentage of responses per questions and of the mean scores showed no significant difference between previous and current studies. This showed that no bias was induced by the psychosocial value carried by the foreign product.
Conclusion: The model developed on the basis of Intersubjectivity Theory explains the process of intent to buy in terms of positive coherence between the intersubjective dimensions. It also shows that analyzing the consumers’ direct perception of the product does not predict their intent to buy. These findings are of great importance for food producers and marketers.
DESTINATION BRANDING OF TERAS CIKAPUNDUNG: A MODEL OF COMMUNICATION STRATEGY
Authors: Rozalena Agustin , Saidah Iis 
Published: August 2020

Penelitian ini bertujuan untuk mengontruksi model strategi komunikasi merek merupakan penelitian dengan objek komunikasi merek kota dengan subjek penelitian para informan yang berkaitan dengan terbangunnya Teras Cikapundung di sekitar bantaran dan sempadan Sungai Cikapundung. Penelitian ini bersifat kualitatif dengan paradigma kontruksi serta analisis studi kasus. Peneliti menggunakan teknik depth interviewing, Focus Group Discussion (FGD), observasi, analisis dokumenserta teknik analisis data menggunakan model interaktif. Hasil penelitian menyatakan 1) proses pembentukan komunikasi merek wisata kota buatan Teras Cikapundung melalui elaborasi Model MESSAGE dan destination branding strategy; 2) adanya strategi wisata buatan Teras Cikapundung berdasarkan tiga unsur penguatan melalui lokasi karyawisata, kesadaran komunitas dan kebersihan lingkungan, Kliatchko’s Model of Integrated Marketing Communication (IMC) dan Strategic Management of Teras Cikapundung’s Brand Communication Programmes; 3) Model strategi komunikasi merek wisata kota buatan Teras Cikapundung yang menunjukkan urutan aktivitas kontruksi strategi yang dilakukan oleh pihak komunikator