bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connexin 43 plays a role in proliferation and migration of pulmonary arterial fibroblasts in response to hypoxia
Authors: McNair Andrew J. , Wilson Kathryn S. , Martin Patricia E. , Welsh David J. , Dempsie Yvonne 
Published: July 2020

Pulmonary hypertension (PH) is a disease associated with vasoconstriction and remodelling of the pulmonary vasculature. Pulmonary artery fibroblasts (PAFs) play an important role in hypoxic‐induced remodelling. Connexin 43 (Cx43) is involved in cellular communication and regulation of the pulmonary vasculature. Using both in vitro and in vivo models of PH, the aims of this study were to (i) investigate the role of Cx43 in hypoxic‐induced proliferation and migration of rat PAFs (rPAFs) and rat pulmonary artery smooth muscle cells (rPASMCs) and (ii) determine whether Cx43 expression is dysregulated in the rat sugen5416/hypoxic model of PH. The role of Cx43 in hypoxic‐induced proliferation and migration was investigated using Gap27 (a pharmacological inhibitor of Cx43) or genetic knockdown of Cx43 using siRNA. Cx43 protein expression was increased by hypoxia in rPAFs but not rPASMCs. Hypoxic exposure, in the presence of serum, resulted in an increase in proliferation of rPAFs but not rPASMCs. Hypoxic exposure caused migration of rPAFs but not rPASMCs. Phosphorylation of p38 mitogen‐activated protein kinase (MAPK) and ERK1/2 were increased by hypoxia in rPAFs. The effects of hypoxia on proliferation, migration and MAPK phosphorylation in rPAFs were attenuated in the presence of Gap27 or Cx43 siRNA. Cx43 protein expression was increased in sugen5416/hypoxic rat lung; this increased expression was not observed in sugen5416/hypoxic rats treated with the MAPK pathway inhibitor GS‐444217. In conclusion, Cx43 is involved in the proliferation and migration of rPAFs in response to hypoxia via the MAPK signalling pathway.
Metabolic endoscopy: Today’s science—tomorrow’s treatment
Authors: Hadefi Alia , Arvanitakis Marianna , Huberty Vincent , Devière Jacques 
Published: July 2020

Obesity, type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis are increasing pandemic metabolic disorders. Lifestyle intervention (LSI) is the cornerstone treatment for these but is successful as standard care alone in only a few patients, given the modest weight loss at mid and long term. Conversely, bariatric surgery is the only proven effective treatment for these metabolic disorders, albeit offered only in a small percentage of cases because of its invasiveness and cost.The so‐called endoscopic bariatric and metabolic therapies (EBMTs) include new, less‐invasive technologies such as intragastric balloons, aspiration therapy, endoscopic sleeve gastroplasty, diversion devices, and duodenal mucosal resurfacing, currently at various stages of development. EBMTs, as an add‐on to LSI, might represent an effective treatment filling the gap between medical and surgical management, taking into account, however, that obesity and its associated comorbidities constitute a chronic disease that needs lifelong therapy. In this review we describe the current scientific evidence surrounding EBMTs as well as future opportunities for such treatments in managing obesity and metabolic disorders.
Black boxes, not green: Mythologizing artificial intelligence and omitting the environment
Authors: Brevini Benedetta 
Published: July 2020

We are repeatedly told that AI will help us to solve some of the world's biggest challenges, from treating chronic diseases and reducing fatality rates in traffic accidents to fighting climate change and anticipating cybersecurity threats. However, the article contends that public discourse on AI systematically avoids considering AI’s environmental costs. Artificial Intelligence- Brevini argues- runs on technology, machines, and infrastructures that deplete scarce resources in their production, consumption, and disposal, thus increasing the amounts of energy in their use, and exacerbate problems of waste and pollution. It also relies on data centers, that demands impressive amounts of energy to compute, analyse, categorize. If we want to stand a chance at tackling the Climate Emergency, then we have to stop avoiding addressing the environmental problems generated by AI.
A comparison of two techniques for center of pressure measurements
Authors: DeBerardinis Jessica , Neilsen Conner , Lidstone Daniel E , Dufek Janet S , Trabia Mohamed B 
Published: July 2020

Introduction Force platforms and pressure-measuring insoles are the most common tools used for measuring center of pressure. Earlier studies to assess these instruments suffered from limited sample sizes or an inadequate range of participant foot sizes. The purpose of this study was to propose new methods to extract and calculate comparably accurate center of pressure for the Kistler® force platform and Medilogic® insoles. Methods Center of pressure data were collected from 65 participants wearing pressure-measuring insoles (six different sizes). Participants walked over consecutive force platforms for three trials while wearing pressure-measuring insoles within socks. Onset force thresholds and center of pressure segment length thresholds were used to determine accurate center of pressure path length and width. A single step for each foot and trial was extracted from both instruments. Results A strong correlation was observed between instruments in center of pressure length (4.12 ± 6.72% difference, r = 0.74). Center of pressure width varied and was weakly correlated (–7.04 ± 4.48% difference, r = 0.11). Conclusions The results indicate that both instruments can measure center of pressure path length consistently and with comparable accuracy (differences < 10%). There were differences between instruments in measuring center of pressure path width, which were attributed to the limited number of sensors across the width of the insoles.
Ureteric mapping with Indocyanine green: A new tool to prevent ureteral injury in complex gynecological surgery
Authors: Rajanbabu Anupama , Patel Viral J 
Published: July 2020

Introduction: The aim of this video is to show that ureteric injection of Indocyanine green dye in difficult gynecological operations is a useful tool to identify and safeguard ureters. Case description: A 56-year-old lady with a large 10.5 × 14.5 × 13 cm3 multiloculated endometriotic cyst in the right adnexa was scheduled for robotic-assisted hysterectomy with bilateral salphingooophorectomy. She had undergone a laparotomy and three laparoscopic surgeries for endometriosis and fibroid uterus. Before starting surgery, cystoscopy was performed and with 6 Fr ureteral catheter inserted into ureteral orifice, 5 mL of 0.5% Indocyanine green dye (Aurolab, Madurai, India) was injected into both ureters. Intraoperatively bilateral adnexal cysts were seen densely adherent to omentum, sigmoid colon, sigmoid mesocolon, bladder, and lateral pelvic wall. Bladder and rectosigmoid were pulled up both anteriorly and posteriorly, respectively, and densely adherent to uterus and to adnexal cysts. During surgery, the course of ureter was identified by the green fluorescence emitted by the Indocyanine green dye under near-infrared light on da Vinci Xi camera. During this difficult surgery, the real-time visualization of ureteric course helped to identify and safeguard ureter during adhesiolysis and surgery could be completed without any injury to ureter. Patient did not experience any side effects due to the ureteric Indocyanine green injection. Conclusion: Endometriosis can distort the pelvic anatomy making surgery very challenging. Identifying the course of ureter during surgery can help in avoiding injuries and reduce surgical morbidity.
The assessment of short- and long-term changes in lung function in cystic fibrosis using129Xe MRI
Authors: Smith Laurie J. , Horsley Alex , Bray Jody , Hughes Paul J.C. , Biancardi Alberto , Norquay Graham , Wildman Martin , West Noreen , Marshall Helen , Wild Jim M. 
Published: July 2020

IntroductionXenon-129 (129Xe) ventilation magnetic resonance imaging (MRI) is sensitive to detect early cystic fibrosis (CF) lung disease and response to treatment.129Xe-MRI could play a significant role in clinical trials and patient management. Here we present data on the repeatability of imaging measurements and their sensitivity to longitudinal change.Methods29 children and adults with CF and a range of disease severity were assessed twice, a median (interquartile range (IQR)) of 16.0 (14.4–19.5) months apart. Patients underwent129Xe-MRI, lung clearance index (LCI), body plethysmography and spirometry at both visits. 11 patients repeated129Xe-MRI in the same session to assess the within-visit repeatability. The ventilation defect percentage (VDP) was the primary metric calculated from129Xe-MRI.ResultsAt baseline, mean±sdage was 23.0±11.1 years and forced expiratory volume in 1 s (FEV1) z-score was −2.2±2.0. Median (IQR) VDP was 9.5 (3.4–31.6)% and LCI was 9.0 (7.7–13.7). Within- and inter-visit repeatability of VDP was high. At 16 months there was no single trend of129Xe-MRI disease progression. Visible129Xe-MRI ventilation changes were common, which reflected changes in VDP. Based on the within-visit repeatability, a significant short-term change in VDP is >±1.6%. For longer-term follow-up, changes in VDP of up to ±7.7% can be expected, or ±4.1% for patients with normal FEV1. No patient had a significant change in FEV1; however, 59% had change in VDP >±1.6%. In patients with normal FEV1, there were significant changes in ventilation and in VDP.Conclusions129Xe-MRI is a highly effective method for assessing longitudinal lung disease in patients with CF. VDP has great potential as a sensitive clinical outcome measure of lung function and end-point for clinical trials.
Do ABC transporters regulate plasma membrane organization?
Authors: Wu Ambroise , Wojtowicz Karolina , Savary Stephane , Hamon Yannick , Trombik Tomasz 
Published: July 2020

AbstractThe plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical properties of the membrane bilayer and thus play a crucial role in all membrane-dependent cellular processes. It is known that lipid content and distribution in the PM are not random, and their transversal and lateral organization is highly controlled. Mainly sphingolipid- and cholesterol-rich lipid nanodomains, historically referred to as rafts, are extremely dynamic “hot spots” of the PM controlling the function of many cell surface proteins and receptors. In the first part of this review, we will focus on the recent advances of PM investigation and the current PM concept. In the second part, we will discuss the importance of several classes of ABC transporters whose substrates are lipids for the PM organization and dynamics. Finally, we will briefly present the significance of lipid ABC transporters for immune responses.
Risk identification and prioritization in banking projects of payment service provider companies: an empirical study
Authors: Khalilzadeh Mohammad , Katoueizadeh Laleh , Zavadskas Edmundas Kazimieras 
Published: July 2020

AbstractIdentifying risks and prioritizing is important for payment service provider (PSP) companies to get banking projects and gain more market share. However, studies regarding the identification of risks and causal relationships are insufficient in the Iranian PSP industry and the industry is unique because of its characteristics. In this study, 30 experts involved with PSP companies are employed as the research sample. Eleven key risks and Forty-six sub-risks are also identified. Subsequently, the fuzzy decision-making trial and evaluation laboratory technique is applied to determine the effective and affected risks and the severity of their effects on each other. Finally, all risks are ranked. Due to the internal interrelationships of the main risks, the weight of each risk is calculated via the fuzzy analytic network process. As the second-level risks have no significant interrelationships, they are ranked via the fuzzy analytical hierarchy process. Moreover, the best-worst method is used to ensure that the obtained rankings are reliable. This study identifies the risks affecting the loss of banking projects and determines the impacts of these risks on each. A sensitivity analysis is then conducted on the weights of the criteria, and the results are compared.
Does occupational licensing impact incomes? A replication study for the German crafts case
Authors: Fredriksen Kaja 
Published: July 2020

AbstractLarge variation in the estimated income premium of occupational licensing can be found in the existing literature. I revisit the natural experimental design of a change in the German crafts regulation in 2004, which removed the traditional licensing requirement for self-employment in certain trades, using official survey data and difference-in-differences estimation. Previous studies of this deregulation have found significant, yet small effects on the incomes of employees in deregulated trades. I focus on the incomes of the self-employed and find no robust effects. Multiple channels through which occupational licensing may affect incomes such as price and quality competition in the regulated market and possible competitive pressure from outsiders are identified, which may also explain why the effects of occupational licensing on incomes appear to be context-specific.
Diversity-guided Lamarckian random drift particle swarm optimization for flexible ligand docking
Authors: Li Chao , Sun Jun , Palade Vasile 
Published: July 2020

Abstract
Background
Protein-ligand docking has emerged as a particularly important tool in drug design and development, and flexible ligand docking is a widely used method for docking simulations. Many docking software packages can simulate flexible ligand docking, and among them, Autodock is widely used. Focusing on the search algorithm used in Autodock, many new optimization approaches have been proposed over the last few decades. However, despite the large number of alternatives, we are still lacking a search method with high robustness and high performance.

Results
In this paper, in conjunction with the popular Autodock software, a novel hybrid version of the random drift particle swarm optimization (RDPSO) algorithm, called diversity-guided Lamarckian RDPSO (DGLRDPSO), is proposed to further enhance the performance and robustness of flexible ligand docking. In this algorithm, a novel two-phase diversity control (2PDC) strategy and an efficient local search strategy are used to improve the search ability and robustness of the RDPSO algorithm. By using the PDBbind coreset v.2016 and 24 complexes with apo-structures, the DGLRDPSO algorithm is compared with the Lamarckian genetic algorithm (LGA), Lamarckian particle swarm optimization (LPSO) and Lamarckian random drift particle swarm optimization (LRDPSO). The experimental results show that the 2PDC strategy is able to enhance the robustness and search performance of the proposed algorithm; for test cases with different numbers of torsions, the DGLRDPSO outperforms the LGA and LPSO in finding both low-energy and small-RMSD docking conformations with high robustness in most cases.

Conclusion
The DGLRDPSO algorithm has good search performance and a high possibility of finding a conformation with both a low binding free energy and a small RMSD. Among all the tested algorithms, DGLRDPSO has the best robustness in solving both holo- and apo-structure docking problems with different numbers of torsions, which indicates that the proposed algorithm is a reliable choice for the flexible ligand docking in Autodock software.
Microecological treatment of hyperuricemia using Lactobacillus from pickles
Authors: Xiao Yuanxun , Zhang Congxin , Zeng Xianli , Yuan Zhichao 
Published: July 2020

Abstract
Background
Hyperuricemia is one of the important risk factors for gout, arteriosclerosis, cardiovascular and cerebrovascular disease. Lactobacillus has attracted much attention due to its role in the regulation of intestinal function and tumor resistance, but its ability to reduce uric acid is unclear. Pickles are a traditional fermented food rich in lactic acid bacteria (LAB).

Results
LAB strains were isolated from 18 pickles and their tolerance to acid bile salts, trypsin, pepsin were evaluated after screening by nucleoside degradation. 16S rDNA sequence analysis was used to identify LAB strains. Furthermore, we established rat model of hyperuricemia and demonstrated that Lactobacillus could alleviate hyperuricemia and reduce kidney injury.

Conclusion
This study suggests that microecological treatment with Lactobacillus represents a feasible option for patients with chronic hyperuricemia.
Nocturia in patients with cognitive dysfunction: a systematic review of the literature
Authors: Haddad Rebecca , Monaghan Thomas F. , Joussain Charles , Phé Véronique , Bower Wendy , Roggeman Saskia , Robain Gilberte , Everaert Karel 
Published: July 2020

Abstract
Background
The objective of this study is to evaluate current literature on the association between cognitive dysfunction and nocturia.

Methods
A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was conducted through MEDLINE, EMBASE and COCHRANE databases and completed in November 2019. Randomized and non-randomized studies were included if they assessed the association between cognitive dysfunction and nocturia in older participants with or without neurological diseases. The quality of included studies was evaluated using the Risk of Bias Assessment tool for Non-randomized Studies (RoBANS).

Results
A total of 8 cross-sectional studies conducted in older patient populations met the criteria for inclusion. A statistically significant association was identified in 6 studies on univariate analysis, which persisted in 2 studies after controlling for confounding factors. The association between cognitive dysfunction and nocturia was positive for all 6 significant analyses. The overall risk of bias was unclear.

Conclusion
A significant positive association between cognitive dysfunction and nocturia was identified. However, research has been limited to cross-sectional studies, which precludes identification of causality between cognitive dysfunction and nocturia. Heightened awareness of the complex interplay between cognition and nocturia would allow professionals involved in the care of cognitively impaired patients with concomitant nocturia to more effectively manage these symptoms.
Myricetin induces apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling in human colon cancer cells
Authors: Zhu Ming-liang , Zhang Pei-min , Jiang Min , Yu Shu-wen , Wang Lu 
Published: July 2020

Abstract
Background
The compound 3,3′,4′,5,5′,7-hexahydroxyflavone (myricetin) is a natural flavonoid with antitumour activity. Most of the studies on myricetin have focused on the induction of tumour cell apoptosis, and little is known about the regulatory effects of myricetin on autophagy in colorectal cancer.

Methods
Here, we studied the effects of myricetin on colon cancer cell proliferation, apoptosis and autophagy. We detected colon cancer cell apoptosis induced by myricetin via flow cytometry and Hoechst 33258 staining. Transmission electron microscopy was performed to observe the morphological changes associated with autophagy. The expression levels of apoptosis-, autophagy- and PI3K/Akt/mTOR signalling-related proteins were measured by Western blot analysis.

Results
This study confirmed that myricetin inhibits the proliferation of 4 kinds of colon cancer cell lines. Myricetin induced cell apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling pathway. In addition, the inhibition of autophagy with 3-methyladenine (3-MA) promoted the apoptosis of myricetin-treated colon cancer cells.

Conclusions
Considering that myricetin induces apoptosis and autophagy in colon cancer cells, myricetin may become a viable candidate for chemotherapy; it could be used to exert tumour inhibitory effects alone or as adjuvant chemotherapy to inhibit autophagy. These studies may provide further evidence for the potential use of myricetin in the treatment of colon cancer.
Comparative efficacy, safety and cost of oral Chinese patent medicines for rheumatoid arthritis: a Bayesian network meta-analysis
Authors: Zhang Dan , Lyu Jin-tao , Zhang Bing , Zhang Xiao-meng , Jiang Hao , Lin Zhi-jian 
Published: July 2020

Abstract
Background
Rheumatoid arthritis (RA) is a common inflammatory disease with a substantial burden for society and economic worldwide. Chinese patent medicines (CPMs) have gained attention as alternative remedies due to they can exert the satisfactory therapeutic effects via holistic regulation. Currently, several oral Chinese patent medicines are routinely recommended for managing and treating RA. Therefore, a network meta-analysis (NMA), which tries to synthesize evidences for a decision making by evaluating the comparative effectiveness of multiple interventions against the same disease, was undertaken to identify the optimal intervention according to their efficacy in clinical treatment and symptom remission, safety profile and daily cost.

Methods
Randomized controlled trials (RCTs) regarding CPMs to treat RA were comprehensive retrieved from 3 foreign databases and 4 Chinese databases, and the retrieved results were last updated on January 10, 2019. The bias of the selected trials was assessed by two individuals independently through RoB2. A random-effects model was adopted during the meta-analytic procedures, and outcomes concerning efficacy and safety were evaluated as odds ratios (OR), mean differences (MD) and 95% credible intervals (CI) utilizing Stata 14.1 and WinBUGS 1.4.3 software. Furthermore, the cluster analysis and comprehensive investigation were preformed concerning the comparative efficacy, safety and cost of oral CPMs.

Results
One hundred sixteen RCTs involving 10,213 individuals met the inclusion criteria and were enrolled into current NMA. The results from existing evidence indicated that Biqi capsule and Yuxuebi capsule probably had a favorable balance in consideration of benefits, tolerability and daily cost. Furthermore, as the least expensive choice, glucosides of Tripterygium Wilfordii tablet was associated with displaying a trend of relieving joint tenderness, joint swelling, and morning stiffness for patients with RA.

Conclusion
Biqi capsule, Yuxuebi capsule and glucosides of Tripterygium Wilfordii tablet were recommended for treating RA based on the favorable benefits in both clinical efficacy and symptoms, and they, meanwhile, might be associated with the more tolerable and acceptable therapeutic alternative in terms of safety profile and daily cost. Nevertheless, the additional results from high-quality, multi-center and head-to-head trials would be pivotal for supporting our findings.