bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Erythroferrone Hormone as Erythroid Regulator of Hepcidin and Iron Metabolism during Thalassemia and in Iron Deficiency Anemia- A Short Review
Authors: Talawy Tiba Sabah , Altoum Abd Elgadir A. , Babker Asaad Ma 
Published: December 2020

Erythroferrone (ERFE) is a hormone produced by erythroblasts in the bone marrow in response to erythropoietin controlling iron storage release through its actions on hepcidin, which acts on hepatocytes to suppress expression of the hormone hepcidin. Erythroferrone now considered is one of potential clinical biomarkers for assessing erythropoiesis activity in patients with blood disorders regarding to iron imbalance. Since discovery of in 2014 by Dr. Leon Kautz and colleagues and till now no more enough studies in Erythroferrone among human, most studies are conducted in animals. In this review we briefly address the Role of Erythroferrone hormone as erythroid regulator of hepcidin and iron metabolism during thalassemia and in iron deficiency anemia. Studies in this review were identified through a search using the following electronic databases: PubMed, Academia, Scopus, Google Scholar, and another open database source. Conclusion: Most of studies concluded that, in people with thalassemia and iron deficiency anemia, erythroferrone levels in the blood are higher than in people without thalassemia and iron deficiency anemia. Knowing the mechanisms of erythroferrone as erythroid regulator of hepcidin and iron metabolism during thalassemia and in iron deficiency anemia important in the diagnosis and treatment for both conditions. The erythroferrone hormone may act as potential factor in physiological hepcidin suppressor in cases with iron deficiency anemia and thalassemia disease and play a key role in treatment process among those patients in status of iron deficiency or iron overload. However, till now few studies of the function of ERFE in humans because is recently discovered and remains to be investigated and most studies are conducted among animals.
Hierarchical Assemblies of Polymer Particles through Tailored Interfaces and Controllable Interfacial Interactions
Authors: Visaveliya Nikunjkumar R. , Köhler Johann Michael 
Published: December 2020

AbstractHierarchical assembly architectures of functional polymer particles are promising because of their physicochemical and surface properties for multi‐labeling and sensing to catalysis and biomedical applications. While polymer nanoparticles’ interior is mainly made up of the cross‐linked network, their surface can be tailored with soft, flexible, and responsive molecules and macromolecules as potential support for the controlled particulate assemblies. Molecular surfactants and polyelectrolytes as interfacial agents improve the stability of the nanoparticles whereas swellable and soft shell‐like cross‐linked polymeric layer at the interface can significantly enhance the uptake of guest nano‐constituents during assemblies. Besides, layer‐by‐layer surface‐functionalization holds the ability to provide a high variability in assembly architectures of different interfacial properties. Considering these aspects, various assembly architectures of polymer nanoparticles of tunable size, shapes, morphology, and tailored interfaces together with controllable interfacial interactions are constructed here. The microfluidic‐mediated platform has been used for the synthesis of constituents polymer nanoparticles of various structural and interfacial properties, and their assemblies are conducted in batch or flow conditions. The assemblies presented in this progress report is divided into three main categories: cross‐linked polymeric network's fusion‐based self‐assembly, electrostatic‐driven assemblies, and assembly formed by encapsulating smaller nanoparticles into larger microparticles.
A Scalable H2O–DMF–DMSO Solvent Synthesis of Highly Luminescent Inorganic Perovskite‐Related Cesium Lead Bromides
Authors: Zhou Bo , Ding Dong , Wang Ye , Fang Shaofan , Liu Zexiang , Tang Jian , Li Henan , Zhong Haizhe , Tian Bingbing , Shi Yumeng 
Published: December 2020

AbstractAll‐inorganic cesium lead bromide perovskites have attracted a lot of attention because of their excellent optical properties that can potentially be applied in various optical devices. However, large‐scale preparation of cesium lead bromide perovskites with outstanding optical performance is still hindered by the poor solubility of CsBr in polar aprotic solvents. In this work, a water/dimethylsulfoxide (DMSO)/dimethylformamide (DMF) system is demonstrated for the synthesis of inorganic cesium lead bromide perovskites, where the introduction of water can effectively address the dissolution issue of Cs+ ions. Large‐scale synthesis of pure‐phase emissive Cs4PbBr6 with a product yield of up to 73% is achieved and the photoluminescence quantum yield of resulting product reaches as high as 76%. The origin of the light emission is further revealed by the photoluminescence evolution of the colored Cs4PbBr6 single crystals. Furthermore, reversible phase transitions between Cs4PbBr6, CsPbBr3 and CsPb2Br5 are achieved by changing solely the water content, which paves the way for the recycle of the mother solution of Cs4PbBr6 without generation of additional hazardous waste. The three‐solvent‐based synthetic approaches enable an economical, robust, and large‐scale production for all‐inorganic cesium lead bromide perovskites.
Ruthenium Catalyzed Regioselective β‐C(sp3)−H Functionalization of N‐Alkyl‐N′‐p–nitrophenyl Substituted Piperazines using Aldehydes as Alkylating Agents
Authors: Murugesh V. , Sahoo Apurba Ranjan , Achard Mathieu , Sharma Gangavaram V. M. , Bruneau Christian , Suresh Surisetti 
Published: December 2020

AbstractHerein, we disclose a ruthenium‐catalyzed regioselective β‐C(sp3)−H bond functionalization on the piperazine core using aldehydes as alkylating agents. The present transformation appears to go through the dehydrogenation of the piperazine to propagate to enamine in situ, followed by nucleophilic addition to the aldehyde and hydrogenation to result in the regioselective β‐C(sp3)−H alkylation. A variety of aromatic, heteroaromatic, aliphatic aldehydes were employed for the C‐3 alkylation of N‐alkyl‐N′‐p‐nitrophenyl substituted piperazines.magnified image
Adult Chinese twins with Kenny–Caffey syndrome type 2: A potential age‐dependent phenotype and review of literature
Authors: Cheng Shirley S. W. , Chan Pui Kwan Joyce , Luk Ho‐Ming , Mok Myth Tsz‐Shun , Lo Ivan F. M. 
Published: December 2020

AbstractKenny–Caffey syndrome (KCS) type 2 (OMIM 127000) is a rare syndromic cause of hypoparathyroidism which is characterized by proportionate short stature, long bone abnormalities, delayed closure of anterior fontanelle, eye abnormalities, and normal intelligence. It is caused by variants in FAM111A (NM_001942519.1). In this review, we reported the first Chinese patients, a pair of monozygotic twins, with genetically confirmed KCS type 2 with over 20 years follow‐up. We summarized the clinical features of 14 previously reported and genetically confirmed KCS type 2 patients; our twin patients exhibited a unique spinal manifestation which could be an important age‐dependent feature of KCS type 2. In this review, over 60% KCS type 2 patients had dental problem and over 80% suffered from refractive errors or structural eye abnormalities. Therefore, early dental, ophthalmological, and orthopedic assessments are warranted for KCS type 2 patients. Micro‐orchidism, previously reported in KCS type 2 patients, was also detected in our patients. The possibility of subfertility should be considered in male KCS type 2 patients. A multidisciplinary management approach for this rare syndrome is recommended.
Process evaluation of solvent‐free lipase‐catalyzed esterification schemes in the synthesis of structured triglycerides from oleic and palmitic acids
Authors: Agapay Ramelito Casado , Ju Yi‐Hsu , Tran‐Nguyen Phuong Lan , Ismadji Suryadi , Angkawijaya Artik Elisa , Go Alchris Woo 
Published: December 2020

AbstractDifferent schemes in the production of structured triglycerides based on solvent‐free esterification of oleic acid and palmitic acid with glycerol were evaluated in terms of reactant conversion, product composition, and yield. Two‐step processes, with or without glycerol dosing, were compared with one‐step versions carried out at temperature conditions within 40°C–60°C to a final oleic acid/palmitic acid/glycerol ratio of 2:1:1, the stoichiometric ratio in 1,3‐dioleoyl‐2‐palmitoyl glycerol (OPO). Substantial amounts of C52 triglycerides, including OPO, were produced in all schemes at 34.98–39.55 wt.% of the total triglycerides and triglyceride yields of 50.10–56.56 wt.% based on the raw materials. The two‐step process with glycerol dosing at 60°C showed the highest palmitic acid incorporation at the sn‐2 position of 46.46%, but the same process carried out with a step increase in temperature from 40°C to 60°C gave the highest OPO yield at 19.30 wt.%. These results demonstrate the possibility of manipulating regioselectivity and triglyceride specificity by varying reactant feeding schemes without the use of solvents and sn‐1,3‐specific lipases common in conventional acidolysis‐based processes.
Analyse von Beton‐Stahlrohrsteckverbindungen für Maste
Authors: Oppeneder Johannes , Dittmar Frank , Tue Nguyen Viet 
Published: December 2020

AbstractDie Beton‐Stahlrohrsteckverbindung wird in dieser Arbeit für die Anwendung bei hybriden Mastkonstruktionen aus der Stahlrohrsteckverbindung weiterentwickelt. Die maßgebende Biegebeanspruchung der Maste wird dabei vom Stahlrohr mit Schubrippen über die Mörtelfuge in das darunterliegende Schleuderbetonrohr eingeleitet. Der Kraftfluss in der Verbindung ändert sich fortlaufend mit der Lastzunahme und wird entscheidend vom Verformungsverhalten der Rohre beeinflusst. Das Trag‐ und Verformungsverhalten der neuen Verbindung wird in diesem Beitrag anhand zweier durchgeführter Großversuche und begleitender FEM‐Simulationen untersucht. Des Weiteren wird anhand zweier variierter Parameter, der Position der Schubrippen sowie einer Steckverbindung ohne Schubrippen der Einfluss auf das Trag‐ und Verformungsverhalten ermittelt und diskutiert.
A Matter of Courtesy: The Role of Soviet Diplomacy and Soviet “System Safeguards” in Maintaining Soviet Influence on Czechoslovak Science before and after 1968
Authors: Olšáková Doubravka 
Published: December 2020

AbstractIn 1969, a few short months after the Warsaw Pact invasion of Czechoslovakia, Sergei I. Prasolov, advisor to the Soviet Ambassador in Prague, informed František Šorm, President of the Czechoslovak Academy of Sciences, at a formal meeting that he welcomed Šorm's suggestion to intensify scientific exchange between Czechoslovakia and the Soviet Union. Šorm politely declined this offer. Behind the veneer of diplomatic courtesy on the part of both actors, a real drama was taking place. Šorm and the Czechoslovak Academy of Sciences had actually never formulated such a request. To the contrary, since the late 1950s the academy had repeatedly pointed out that the Soviets were incapable of coordinating scientific activities in the Eastern Bloc. The Soviet system of academic cooperation within the Eastern Bloc had already begun to collapse after the Geneva Summit of 1955, where the Soviets opened the door to international collaboration across the Iron Curtain. Yet it was only in the late 1960s that the Soviets realized that while they dominated large‐scale international collaboration, they had lost control of internal developments within the Eastern Bloc.
Impact of insurance and neighborhood socioeconomic status on clinical outcomes in therapeutic clinical trials for breast cancer
Authors: Obeng‐Gyasi Samilia , O’Neill Anne , Zhao Fengmin , Kircher Sheetal M. , Lava Timisina R. , Wagner Lynne I. , Miller Kathy D. , Sparano Joseph DA. , Sledge George W. , Carlos Ruth C. 
Published: December 2020

AbstractThe objective of this study was to evaluate the impact of insurance and neighborhood SES (nSES) on chemotherapy completion and overall mortality among participants in breast cancer clinical trials. The data sources for this study were two adjuvant breast cancer trials (ECOG E1199 and E5103) collectively including 9790 women. Insurance status at trial registration was categorized into private, government (Medicaid, Medicare, and other government type insurance), and self‐pay. An Agency for Healthcare Research Quality (AHRQ) nSES index was calculated using residential zip codes linked to county level data on occupation, income, poverty, wealth, education, and crowding. Logistic regression and Cox Proportional Hazard models estimated odds ratios (OR) for chemotherapy treatment completion and hazard ratios (HR) for mortality, respectively, for insurance status and nSES. The models adjusted for: race, age, tumor size, nodal status, hormone receptor status, and primary surgery. The majority of patients had private insurance at trial registration: E1199: 85.6% (4154/4854) and E5103: 82.4% (3987/4836); median SES index was 53.8 (range: 41.8‐66.8) and 54.1 (range: 44.5‐66.1), respectively. Patients with government insurance were less likely to complete chemotherapy treatment (E1199 OR (95%CI): 0.73 (0.57‐0.94); E5103 0.76 (0.64‐0.91)) and had an increased risk of death (E1199 HR (95%CI): 1.44 (1.22‐1.70); E5103 1.29 (1.06‐1.58)) compared to the privately insured patients. There was no association between nSES and chemotherapy completion or overall mortality. Patients with government insurance at trial registration appeared to face barriers in chemotherapy completion and had a higher overall mortality compared to their privately insured counterparts.
New Volume‐Stable Collagen Matrix and Modified Coronally Advanced Flap to Treat Multiple Gingival Recessions Associated With Partially Restored Non‐Carious Cervical Lesions: A Case Report
Authors: Santamaria Mauro Pedrine , Miguel Manuela Maria Viana , Rossato Amanda , Bonafé Ana Carolina Ferreira , Ferraz Laís Fernanda Ferreira , dos Santos Lucio Murilo , Mathias‐Santamaria Ingrid Fernandes 
Published: December 2020

IntroductionGingival recession (GR) is a prevalent problem that is related to esthetic demands and dentin hypersensitivity. Frequently, GR is associated with non‐carious cervical lesion (NCCLs) forming a combined defect (CD), which requires restorative and surgical treatment. Connective tissue graft procedures allow predictable root coverage but can result in patient discomfort.Case PresentationThis first case report describes multiple GRs associated with B+ NCCL at teeth #4 and #6 of a 27‐year‐old patient with a thin periodontal phenotype. The aim of this report was to evaluate the 6‐month outcome of a new volume‐stable collagen matrix (VCMX) combined with modified coronally advanced flap (MCAF) and partial restoration to treat CDs. After 6 months, significant improvement was observed regarding CD coverage (69.05%), recession reduction (2.25 mm), gingival thickness gain (0.74 mm), and keratinized tissue width gain (0.75 mm). In addition, excellent esthetic evaluation and patient comfort were achieved by using the biomaterial.ConclusionVCMX associated with MCAF and partial restoration may be an option to treat multiple recession defects plus B+ NCCLs.
Propensity to use smartbands to engage with brands and the moderating role of the bandwagon effect on satisfaction
Authors: Oyedele Adesegun , Goenner Emily 
Published: December 2020

AbstractThis study investigated factors that predict propensity to use smartbands to engage with brands. The study shows that the bandwagon effect moderates the relationship between self‐monitoring, personal attachment, ease of use, convenience value, and satisfaction with smartbands. Since the strong bandwagon effect diminishes the relationship between perceived ease of use and satisfaction levels, managers can take steps to moderate that relationship. As compared to previous customer engagement studies rooted in the traditional idea of personalized communication with consumers, such as customized emails and messages, this study underscores the importance of community engagement by studying the bandwagon effect to see how different customers respond to brand engagement through smartbands. Suggestions for managers are provided.
Can human brands help consumers eat better? Influence of emotional brand attachment, self‐identification, and brand authenticity on consumer eating habits
Authors: Guèvremont Amélie 
Published: December 2020

AbstractThis research studies the positive role of culinary human brands in helping consumers improve their eating habits (i.e., eat healthier, adopt a varied diet, and cook more) through the influence of emotional brand attachment—induced by actual and ideal self‐congruence—and while considering the moderating role of perceived brand authenticity. An online questionnaire was administered to 501 adults from a panel. Participants had to meet specific criteria—having a strong interest in food and cooking and being highly attached to a culinary human brand. Results were analyzed through structural equation modeling. Results reveal the influence of attachment in helping consumers improve their eating habits. The role of connection with consumer identity in inducing attachment is supported and characterized by a greater impact of the actual self. The moderating influence of brand authenticity is confirmed. This research suggests that culinary human brands can positively influence consumer food‐related decisions by serving as relevant identity resources. Results indicate that focusing on authenticity is a promising strategy to pursue human brands. Overall, this research calls for brands to think about how they can positively impact consumer lives, more specifically by helping them make better food decisions, ultimately contributing to their well‐being.
Chemical Constituents of Species in the Genus Pleione (Orchidaceae) and the Implications from Molecular Phylogeny
Authors: Zhang Wei , Zhang Lin‐Fei , Deng Yu , Qin Jiao , Zhang Shi‐Bao , Hu Jiang‐Miao 
Published: December 2020

AbstractPleiones are popular ornamental orchids and different species of Pleione are long being used as traditional medicine in many Asian countries. However, previous chemical investigations of the genus Pleione are restricted to only a few species. In the present study, high performance liquid chromatography (HPLC) fingerprint of Pleione plants was established, which in particular, eight common peaks were confirmed in 16 species/hybrids. Three of the compounds corresponding to the chromatographic peaks were identified by electrospray ionization tandem mass spectrometry (ESI‐tandem‐MS). HPLC analysis confirmed the studied taxa shared most of chemical compounds but the content of chemical compounds was significantly different between species. Comparison of hierarchical clustering result with phylogenetic tree revealed that closely related species have higher similarities in chemical constituents. In consideration of low chemical similarity between spring‐flowering and autumn‐flowering species, we suggest a discrimination of these two groups during medicinal use of the genus Pleione. Species with a large pseudobulb and with high content of a certain compound should be given priority in future artificial cultivation and medicinal cultivar breeding. We hope our findings will contribute to the quality control and promote conservation of such endangered plant group.
miR‐34a attenuates myocardial fibrosis in diabetic cardiomyopathy mice via targeting Pin‐1
Authors: Zhang Xiao‐long , Zhang Gang , Bai Ze‐hong 
Published: December 2020

AbstractDiabetic cardiomyopathy (DCM) is characterized by myocardial hypertrophy and fibrosis. This study aimed to investigate the effects of microRNA (miR)‐34a on myocardial fibrosis in DCM and its potential mechanism of targeting Pin‐1 signaling. Vimentin and Pin‐1 proteins in mouse cardiac tissues were detected by immunohistochemical staining. Locked nucleic acid in situ hybridization was used to measure miR‐34a expression in cardiac tissues. Primary mouse cardiac fibroblasts (CFs) were transfected with a mimics control/miR‐34a mimics or Pin‐1 plasmid and cultured in high‐glucose (HG) Dulbecco's modified Eagle's medium. The miR‐34a levels were measured by quantitative polymerase chain reaction. The apoptosis and viability of transfected cells were detected by the terminal deoxynucleotidyl transferase dUTP nick end labeling and Cell Counting Kit‐8 assays respectively. A cell migration experiment and dual‐luciferase reporter assay were also performed. The body weight and fasting blood glucose of DCM mice were significantly higher than those in the control (CTL) group. In addition, DCM mice had decreased serum insulin levels and impaired cardiac function. The number of CFs in the DCM group was higher than in the CTL group and Pin‐1 expression was upregulated. The expression level of miR‐34a in the cardiac tissue of mice in the DCM group was obviously downregulated compared with the CTL group. The HG stimulation of CFs for 48 h significantly downregulated the expression level of miR‐34a and was associated with increased Type I collagen expression, cell viability, and migration and decreased apoptosis. However, these effects could be reversed by overexpressing miR‐34a in HG‐induced CFs. Furthermore, we found that Pin‐1 was a direct target of miR‐34a. Our results suggest that miR‐34a can attenuate myocardial fibrosis in DCM by reducing Type I collagen production, cell viability, and migration and increasing the apoptosis of CFs by targeting Pin‐1 signaling.
Predicting the Sonochemical Efficiency for Water Decontamination: An Upscaled Numerical Approach
Authors: Kerboua Kaouther , Hamdaoui Oualid , Alghyamah Abdulaziz 
Published: December 2020

AbstractA numerical modeling approach is presented, predicting the sonochemical efficiency for water decontamination integrally based on microscale activity of a single bubble, coupled to macroscale energetic balance on a batch sonochemical reactor volume. The sonochemical efficiency is axed on the powerful oxidative effect of HO• radicals on organic substrates. Spatial average values of bubble number densities were estimated at each instant of the acoustic period along a reactor of a hypothetical length λ. As a direct result, the kinetics of the sonochemical emergence of HO• led to spatial average production rates of 0.251 and 0.299 µmol dm−3min−1 under respective frequencies of 20 and 443 kHz, for a defined irradiation time of 50 µs.