bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child hand contamination is associated with subsequent pediatric diarrhea in rural Democratic Republic of the Congo (REDUCE Program)
Authors: George Christine Marie , Cirhuza Lucien Bisimwa , Birindwa Alves , Williams Camille , Beck Sara , Julian Timothy , Kuhl Jennifer , Coglianese Nicole , Thomas Elizabeth , Bauler Sarah , François Ruthly , Saxton Ronald , Presence Amani Sanvura , Rusanga Jean Claude Bisimwa , Perin Jamie , Mirindi Patrick 
Published: November 2020

AbstractObjectiveThe Reducing Enteropathy, Undernutrition, and Contamination in the Environment (REDUCE) program focuses on identifying exposure pathways to faecal pathogens for young children in the Democratic Republic of the Congo (DRC) and on developing scalable interventions to reduce faecal contamination from these pathways.MethodsA prospective cohort study of 690 participants was conducted to investigate the association between hand, food, and environmental faecal contamination and diarrhoeal disease prevalence among young children in Walungu Territory, South Kivu, DRC. A total of 1923 hand rinse, soil, food, object, surface, stored water and water source samples were collected during unannounced spot checks after baseline enrolment and analysed for Escherichia coli. Caregiver reports of diarrhoea were obtained from children < 5 years at a 6‐month follow‐up.ResultsE.coli was detected in 73% of child and caregiver hand‐rinse samples, 69% of soil samples from child play spaces, 54% of child food samples, 38% of objects and surfaces children were observed putting in their mouths, 74% of stored water samples, and 40% of source water samples. Children < 5 years with E. coli on their hands had significantly higher odds of diarrhoea at the 6‐month follow‐up (odds ratio: 2.03 (95% confidence interval: 1.05, 3.92)).ConclusionThe cohort study findings from the REDUCE program have shown that child hand contamination is associated with diarrhoeal disease in rural DRC, and that there is high faecal contamination in child plays spaces and food. These findings provide evidence demonstrating the urgent need to provide clean play spaces for young children and interventions targeting hand hygiene to reduce paediatric exposure to faecal pathogens.
The effectiveness of non-pharmacologic treatments compared to pharmacologic treatments in veterans with sleep disturbances: a systematic review protocol
Authors: Albanese Beau , Palokas Michelle 
Published: November 2020

ABSTRACT

Objective:
The objective is to determine the effectiveness of non-pharmacologic treatments compared to pharmacologic treatments in veterans with sleep disturbances.

Introduction:
Sleep disturbances in veterans are a common occurrence. If left untreated, these individuals are susceptible not only to accidents and injuries but long-term psychiatric and/or cardiovascular complications.

Inclusion criteria:
This review will consider studies of veterans, aged 18 and over, with a diagnosis of sleep disturbances. This study will exclude patients with psychotic disorders, obstructive sleep apnea, or other medical illnesses causing disrupted sleep.

Methods:
This review will use the JBI methodology for evidence of effectiveness. The search will be limited to studies published in English after 1970. The databases to be searched include MEDLINE (PubMed), CINAHL (EBSCO), Embase (Elsevier), Scopus (Elsevier), and PsycINFO (EBSCO). The trial registers to be searched include US National Library of Medicine (ClinicalTrials.gov) and Cochrane Library. The search for unpublished studies will include ProQuest Dissertations and Theses, MedNar, and WorldWideScience. Eligible studies will undergo critical appraisal and data extraction by two independent reviewers using standardized critical appraisal instruments and a data extraction tool from JBI. Studies will be pooled in statistical meta-analysis when possible. When statistical pooling is not possible, the findings will be presented in narrative form with tables and figures.

Systematic Review Registration Number:
PROSPERO (CRD42019140804)
Kv11 (ether‐à‐go‐go‐related gene) voltage‐dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials
Authors: Matsuoka Toshinori , Yamasaki Miwako , Abe Manabu , Matsuda Yukiko , Morino Hiroyuki , Kawakami Hideshi , Sakimura Kenji , Watanabe Masahiko , Hashimoto Kouichi 
Published: November 2020

Key points
Some ion channels are known to behave as inductors and make up the parallel resonant circuit in the plasma membrane of neurons, which enables neurons to respond to current inputs with a specific frequency (so‐called ‘resonant properties’).
Here, we report that heterologous expression of mouse Kv11 voltage‐dependent K+ channels generate resonance and oscillation at depolarized membrane potentials in HEK293 cells; expressions of individual Kv11 subtypes generate resonance and oscillation with different frequency properties.
Kv11.3‐expressing HEK293 cells exhibited transient conductance changes that opposed the current changes induced by voltage steps; this probably enables Kv11 channels to behave like an inductor.
The resonance and oscillation of inferior olivary neurons were impaired at the resting membrane potential in Kv11.3 knockout mice.
This study helps to elucidate basic ion channel properties that are crucial for the frequency responses of neurons.
AbstractThe plasma membranes of some neurons preferentially respond to current inputs with a specific frequency, and output as large voltage changes. This property is called resonance, and is thought to be mediated by ion channels that show inductor‐like behaviour. However, details of the candidate ion channels remain unclear. In this study, we mainly focused on the functional roles of Kv11 potassium (K+) channels, encoded by ether‐á‐go‐go‐related genes, in resonance in mouse inferior olivary (IO) neurons. We transfected HEK293 cells with long or short splice variants of Kv11.1 (Merg1a and Merg1b) or Kv11.3, and examined membrane properties using whole‐cell recording. Transfection with Kv11 channels reproduced resonance at membrane potentials depolarized from the resting state. Frequency ranges of Kv11.3‐, Kv11.1(Merg1b)‐ and Kv11.1(Merg1a)‐expressing cells were 2–6 Hz, 2–4 Hz, and 0.6–0.8 Hz, respectively. Responses of Kv11.3 currents to step voltage changes were essentially similar to those of inductor currents in the resistor–inductor–capacitor circuit. Furthermore, Kv11 transfections generated membrane potential oscillations. We also confirmed the contribution of HCN1 channels as a major mediator of resonance at more hyperpolarized potentials by transfection into HEK293 cells. The Kv11 current kinetics and properties of Kv11‐dependent resonance suggested that Kv11.3 mediated resonance in IO neurons. This finding was confirmed by the impairment of resonance and oscillation at –30 to –60 mV in Kcnh7 (Kv11.3) knockout mice. These results suggest that Kv11 channels have important roles in inducing frequency‐dependent responses in a subtype‐dependent manner from resting to depolarized membrane potentials.
The nanogeochemistry of abiotic carbonaceous matter in serpentinites from the Yap Trench, western Pacific Ocean
Authors: Nan(南景博) Jingbo , King Helen E. , Delen Guusje , Meirer Florian , Weckhuysen Bert M. , Guo(郭自晓) Zixiao , Peng(彭晓彤) Xiaotong , Plümper Oliver 
Published: November 2020

Abstract
Serpentinization may provide a unique environment for the abiotic formation of condensed carbonaceous matter. This could support the deep biosphere and contribute to the deep carbon cycle, and may have provided the first building blocks for life. However, thus far, condensed carbonaceous matter has been found only in association with the minor mineral constituents of serpentinites. In contrast, here we show the direct association between carbonaceous matter and the dominant Fe oxide in serpentinites, magnetite. Our samples were recovered from the Yap Trench, western Pacific Ocean, with a human-occupied vehicle at a depth of 6413 m below sea level. The carbonaceous matter coincides with some micron-sized magnetite grains, but particularly with nanosized Fe oxides within serpentinite nanopores. Vibrational spectroscopy reveals that the condensed carbonaceous matter contains both aliphatic and aromatic compounds, but there is no evidence for functional groups typical for biological organics. Based on these observations, we suggest that physicochemical phenomena in serpentinite nanopores and nanosized catalytically active minerals may play a key role in the abiotic synthesis of complex carbonaceous matter.
Initiation and evolution of knickpoints and their role in cut-and-fill processes in active submarine channels
Authors: Guiastrennec-Faugas Léa , Gillet Hervé , Peakall Jeff , Dennielou Bernard , Gaillot Arnaud , Jacinto Ricardo Silva 
Published: November 2020

Abstract
Submarine channels are the main conduits and intermediate stores for sediment transport into the deep sea, including organics, pollutants, and microplastics. Key drivers of morphological change in channels are upstream-migrating knickpoints whose initiation has typically been linked to episodic processes such as avulsion, bend cutoff, and tectonics. The initiation of knickpoints in submarine channels has never been described, and questions remain about their evolution. Sedimentary and flow processes enabling the maintenance of such features in non-lithified substrates are also poorly documented. Repeated high-resolution multibeam bathymetry between 2012 and 2018 in the Capbreton submarine canyon (southeastern Bay of Biscay, offshore France) demonstrates that knickpoints can initiate autogenically at meander bends over annual to multi-annual time scales. Partial channel clogging at tight bends is shown to predate the development of new knickpoints. We describe this initiation process and show a detailed morphological evolution of knickpoints over time. The gradients of knickpoint headwalls are sustained and can grow over time as they migrate through headward erosion. This morphology, associated plunge pools, and/or development of enhanced downstream erosion are linked herein to the formation and maintenance of hydraulic jumps. These insights of autogenically driven, temporally high-frequency knickpoints reveal that cut-and-fill cycles with depths of multiple meters can be the norm in submarine systems.
Feasibility of using patient-reported outcome measures with visually impaired children/young people attending paediatric ophthalmology clinics
Authors: Robertson Alexandra O , Tadić Valerija , Cortina-Borja Mario , Rahi Jugnoo 
Published: November 2020

ABSTRACTObjectiveTo explore feasibility of using child/young person patient-reported outcome measures (PROMs) routinely in practice, using vision-specific instruments and paediatric ophthalmology as the exemplar.MethodsParticipants comprised patients aged 8–17 years, with visual impairment or low vision (visual acuity of the logarithm of the minimum angle of resolution (logMAR) worse than 0.3 in the better eye), attending the Department of Ophthalmology at Great Ormond Street Hospital, London, UK. All participants completed age-appropriate PROMs before attending their outpatient appointment. Half were randomly assigned to completion at home, with the choice of paper-and-pencil or electronic format. The other half were invited to complete PROMs during their hospital appointment, and randomly assigned to completion format. All participants completed a face-to-face survey exploring their attitudes and preferences. Analysis comprised survival analysis, and direct comparisons of proportions, with complementary qualitative data analysis.Results93 patients participated. 48 (98%) completing PROMs at home chose the paper-and-pencil format. Completion at home took longer than at hospital (median=20, vs 14 min, p<0.001). Visual acuity was associated with completion time (p=0.007) and missing data (p=0.03). Overall, 52 (60%) reported a preference for completion at home but there was no clear preference for format (37 (43%) preferred either format).ConclusionPROM completion at home ahead of hospital appointments may be preferable for collecting complete, high-quality datasets. Despite equipoise on preference for format, the majority of those completing at home chose the traditional paper-and-pencil format, despite impaired sight. These findings should inform implementation of child/young person PROMs into routine practice.
OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery
Authors: Shoji Takuhei , Kanno Junji , Weinreb Robert N , Yoshikawa Yuji , Mine Izumi , Ishii Hirokazu , Ibuki Hisashi , Shinoda Kei 
Published: November 2020

Background/AimsTo evaluate quantitative changes in the foveal avascular zone (FAZ) area after glaucoma surgery using swept-source optical coherence tomography angiography (SS-OCTA).MethodsFifty-four consecutive patients with primary open-angle glaucoma (POAG) who met the inclusion criteria and underwent unilateral glaucoma surgery to reduce intraocular pressure (IOP) between April 2018 and July 2019.Eyes underwent IOP-lowering glaucoma surgery and their fellow (non-surgical) eyes were included. OCTA of the macula was performed in both eyes before glaucoma surgery and 3 months postoperatively. Two blinded examiners reviewed the image quality. Within- and between-group comparisons of the FAZ area and correlation of the FAZ area with age, IOP, central sensitivity and clinical variables.ResultsThe mean (±SD) age was 66.7±11.3 years. After surgery, the IOP and FAZ area significantly decreased from 22.1±9.5 mmHg to 10.3±3.5 mmHg and from 0.485±0.193 mm2 to 0.446±0.174 mm2, respectively (both p<0.001). Conversely, in the non-surgery group, the preoperative and postoperative mean FAZ areas (0.398±0.119 mm2 and 0.396±0.110 mm2, respectively) did not significantly differ (p=0.469). Change in the FAZ area significantly correlated with the preoperative FAZ area, preoperative foveal sensitivity and change in IOP (all p<0.05).ConclusionsThe FAZ area is decreased with IOP-lowering surgery in patients with POAG, and change in the FAZ area was significantly correlated with both preoperative foveal sensitivity and change in IOP.
Postural sway correlates with cognition and quality of life in Parkinson’s disease
Authors: Apthorp Deborah , Smith Alex , Ilschner Susanne , Vlieger Robin , Das Chandi , Lueck Christian J , Looi Jeffrey C L 
Published: November 2020

BackgroundThe severity of Parkinson’s disease (PD) is difficult to assess objectively owing to the lack of a robust biological marker of underlying disease status, with consequent implications for diagnosis, treatment and prognosis. The current standard tool is the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), but this is hampered by variability between observers and within subjects. Postural sway has been shown to correlate with complex brain functioning in other conditions. This study aimed to investigate the relationship between postural sway, MDS-UPDRS and other non-motor measures of disease severity in patients with PD.Method25 patients with PD and 18 age-matched controls participated in the study. All participants underwent assessment of postural sway using a force plate, with eyes open and closed. In addition, participants underwent tests of cognition and quality of life: Montreal Cognitive Assessment (MoCA), Neuropsychiatry Unit Cognitive Assessment (NUCOG) and, for the patients, the Parkinson’s Disease Questionnaire (PDQ-39–1), and assessment of clinical status using the motor component of the MDS-UPDRS.ResultsPatients swayed significantly more than controls. This was most obvious in the eyes-closed condition. Sway path length showed strong correlations with PDQ-39–1, MoCA and the verbal fluency component of the NUCOG, and, to a lesser degree, with the UPDRS-III in patients with PD.ConclusionThese results suggest that motor and non-motor symptoms of PD are associated in patients, and, in particular, that postural sway shows potential as a possible measure of underlying disease status in PD, either alone or in combination with other measures.
Novel electronic adherence monitoring devices in children with asthma: a mixed-methods study
Authors: Makhecha Sukeshi , Chan Amy , Pearce Christina , Jamalzadeh Angela , Fleming Louise 
Published: November 2020

IntroductionAdherence monitoring to inhaled corticosteroids is an essential component of asthma management. Electronic monitoring devices (EMD) provide objective data on date, time and number of actuations. However, most give no information on inhalation. Novel EMD (NEMD) platforms have the potential to monitor both activation and inhalation.AimTo assess the feasibility of NEMDs, in terms of usability, acceptability to patients and healthcare professionals and accuracy.MethodsThis was an open-label, prospective, mixed-methods, pragmatic randomised study. Children with asthma attending specialist tertiary care were randomised to one of four NEMD: Remote Directly Observed Therapy (R-DOT), Hailie Smartinhaler, INhaler Compliance Assessment device (INCA) and the Rafi-tone App. Following monitoring, participants were invited to focus groups or one-to-one interviews. Usability and acceptability were evaluated using themes identified from the focus groups and interviews. Adherence accuracy was determined using adherence data from each NEMD.ResultsThirty-five children were recruited; 18 (51%), (11 males, median age 13.5 (7–16) years) completed monitoring, 14 (78%) provided feedback. Participants identified various features such as ease of use and minimal effort as desirable criteria for an NEMD. The Hailie and INCA fulfilled these criteria and were able to record both actuation and inhalation. Negative themes included a ‘Big Brother’ effect and costs.ConclusionThere was no ‘one size fits all’, as participants identified advantages and disadvantages for each NEMD. Devices that can easily calculate adherence to activation and inhalation have the potential to have greatest utility in clinical practice. Each NEMD has different functionality and therefore choice of platform should be determined by the needs of the patient and healthcare professional.
Association of heart failure and its comorbidities with loss of life expectancy
Authors: Drozd Michael , Relton Samuel D , Walker Andrew M N , Slater Thomas A , Gierula John , Paton Maria F , Lowry Judith , Straw Sam , Koshy Aaron , McGinlay Melanie , Simms Alexander D , Gatenby V Kate , Sapsford Robert J , Witte Klaus K , Kearney Mark T , Cubbon Richard M 
Published: November 2020

ObjectiveEstimating survival can aid care planning, but the use of absolute survival projections can be challenging for patients and clinicians to contextualise. We aimed to define how heart failure and its major comorbidities contribute to loss of actuarially predicted life expectancy.MethodsWe conducted an observational cohort study of 1794 adults with stable chronic heart failure and reduced left ventricular ejection fraction, recruited from cardiology outpatient departments of four UK hospitals. Data from an 11-year maximum (5-year median) follow-up period (999 deaths) were used to define how heart failure and its major comorbidities impact on survival, relative to an age–sex matched control UK population, using a relative survival framework.ResultsAfter 10 years, mortality in the reference control population was 29%. In people with heart failure, this increased by an additional 37% (95% CI 34% to 40%), equating to an additional 2.2 years of lost life or a 2.4-fold (2.2–2.5) excess loss of life. This excess was greater in men than women (2.4 years (2.2–2.7) vs 1.6 years (1.2–2.0); p<0.001). In patients without major comorbidity, men still experienced excess loss of life, while women experienced less and were non-significantly different from the reference population (1 year (0.6–1.5) vs 0.4 years (−0.3 to 1); p<0.001). Accrual of comorbidity was associated with substantial increases in excess lost life, particularly for diabetes, chronic kidney and lung disease.ConclusionsComorbidity accounts for the majority of lost life expectancy in people with heart failure. Women, but not men, without comorbidity experience survival close to reference controls.
Gender, marital and educational inequalities in mid- to late-life depressive symptoms: cross-cohort variation and moderation by urbanicity degree
Authors: Ruiz Milagros A , Beenackers Marielle A , Doiron Dany , Gurer Asli , Sarr Aliou , Sohel Nazmul , Timmermans Erik J , Wissa Rita , Chaix Basile , Huisman Martijn , Krokstad Steinar , Kubinova Ruzena , Malyutina Sofia , Raina Parminder , Tamosiunas Abdonas , van Lenthe Frank J , Bobak Martin 
Published: November 2020

BackgroundAlthough ageing populations are increasingly residing in cities, it is unknown whether depression inequalities are moderated by urbanicity degree. We estimated gender, marital and educational inequalities in depressive symptoms among older European and Canadian adults, and examined whether higher levels of urbanicity, captured by population density, heightened these inequalities.MethodsHarmonised cross-sectional data on 97 826 adults aged ≥50 years from eight cohorts were used. Prevalence ratios (PRs) were calculated for probable depression, depressed affect and depressive symptom severity by gender, marital status and education within each cohort, and combined using random-effects meta-analysis. Using a subsample of 73 123 adults from six cohorts with available data on population density, we tested moderating effects measured by the number of residents per square kilometre.ResultsThe pooled PRs for probable depression by female gender, unmarried or non-cohabitating status and low education were 1.48 (95% CI 1.28 to 1.72), 1.44 (95% CI 1.29 to 1.61) and 1.29 (95% CI 1.18 to 1.41), respectively. PRs for depressed affect and high symptom severity were broadly similar. Except for one Dutch cohort with findings in an unexpected direction, there was no evidence that population density modified depressive symptom inequalities.ConclusionsDespite cross-cohort variation in gender, marital status and educational inequalities in depressive symptoms, there was weak evidence that these inequalities differed by levels of population density.
Middle-age dementia risk scores and old-age cognition: a quasi-experimental population-based twin study with over 20-year follow-up
Authors: Iso-Markku Paula , Kaprio Jaakko , Lindgren Noora , Rinne Juha O , Vuoksimaa Eero 
Published: November 2020

BackgroundMiddle-age risk scores predict cognitive impairment, but it is not known if these associations are evident when controlling for shared genetic and environmental factors. Using two risk scores, self-report educational-occupational score and Cardiovascular Risk Factors, Aging and Dementia (CAIDE), we investigated if twins with higher middle-age dementia risk have poorer old-age cognition compared with their co-twins with lower risk.MethodsWe used a population-based older Finnish Twin Cohort study with middle-age questionnaire data (n=15 169, mean age=52.0 years, SD=11.8) and old-age cognition measured via telephone interview (mean age=74.1, SD=4.1, n=4302). Between-family and within-family linear regression analyses were performed.ResultsIn between-family analyses (N=2359), higher educational-occupational score was related to better cognition (B=0.76, 95% CI 0.69 to 0.83) and higher CAIDE score was associated with poorer cognition (B=−0.73, 95% CI −0.82 to -0.65). Within twin-pair differences in educational-occupational score were significantly related to within twin-pair differences in cognition in dizygotic (DZ) pairs (B=0.78, 95% CI 0.25 to 1.31; N=338) but not in monozygotic (MZ) pairs (B=0.12, 95% CI −0.44 to 0.68; N=221). Within twin-pair differences in CAIDE score were not related to within twin-pair differences in cognition: DZ B=−0.38 (95% CI −0.90 to 0.14, N=343) and MZ B=−0.05 (95% CI −0.59 to 0.49; N=226).ConclusionMiddle-age dementia risk scores predicted old-age cognition, but within twin-pair analyses gave little support for associations independent of shared environmental and genetic factors. Understanding genetic underpinnings of risk score−cognition associations is important for early detection of dementia and designing intervention trials.