bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of fuzzy logic in wireless localization
Authors: Alakhras Marwan , Oussalah Mourad , Hussein Mousa 
Published: May 2020

AbstractPositioning and location estimation of targets either for mobile or stationary nodes is very important, especially after the astonishing developments of the wired and/or wireless communications, as well as the popularity of handheld devices. To assist in accessing services or managing resources, numerous users, application developers, and service providers require accurate position information. Owing to the boom of multisensory systems, wireless technology, and autonomous systems, many positioning systems have been proposed. These positioning systems differ based on the adopted technology, type of sensory information, communication protocol, algorithm, and accuracy level. These different approaches impose a non-negligible amount of uncertainty and challenges; in such case, fuzzy-logic-based localization systems offer an attractive and feasible approach to overcome some of the reported challenges and handle uncertainties, depending on its proven mathematical framework for handling vagueness and uncertainty. Intuitively, fuzzy sets and fuzzy inference systems are initially intended to incorporate granularity and flexibility of human knowledge, which characterize complex system behaviors without explicitly requiring precise mathematical models or when a complete and exhaustive list of comprehending factors are ill known.This study demonstrates the benefits of fuzzy sets, fuzzy logic, and fuzzy inference systems in wireless positioning problems. Notably, as a way to benefit both the academic community and practitioners of system positioning, we review and investigate various fuzzy-related techniques and methodologies. To the best of our knowledge, this is the first comprehensive review that focuses solely on fuzzy-based positioning systems.
Determining optimal strategies for primary prevention of cardiovascular disease: systematic review, cost-effectiveness review and network meta-analysis protocol
Authors: Uthman Olalekan A. , Al-Khudairy Lena , Nduka Chidozie U. , Court Rachel , Mistry Hema , Melendez-Torres G . J. , Taylor-Phillips Sian , Clarke Aileen 
Published: May 2020

Abstract
Background
Despite recent improvements in the burden of cardiovascular disease (CVD) in the UK, deaths from CVD are relatively high compared with other high-income countries. An estimated 7 million people in the UK are living with CVD, and the healthcare cost is approximately £11 billion annually. In more than 90% of cases, the risk of a first heart attack is thought to be related to modifiable risk factors including smoking, poor diet, lipidemia, high blood pressure, inactivity, obesity and excess alcohol consumption. The aim of the study is to synthesise evidence for the comparative effectiveness and cost-effectiveness of different interventions for the primary prevention of CVD.

Methods
We will systematically search databases (for example, MEDLINE (Ovid), Embase (Ovid), Cochrane Library) and the reference lists of previous systematic reviews for randomised controlled trials that assess the effectiveness and cost-effectiveness of any form of intervention aimed at adult populations for the primary prevention of CVD, including but not limited to lipid lowering medications, blood pressure lowering medications, antiplatelet agents, nutritional supplements, dietary interventions, health promotion programmes, physical activity interventions or structural and policy interventions. Interventions may or may not be targeted at high-risk groups. Publications from any year will be considered for inclusion. The primary outcome will be all cause mortality. Secondary outcomes will be cardiovascular diseases related mortality, major cardiovascular events, coronary heart disease, incremental costs per quality-adjusted life years gained. If data permits, we will use network meta-analysis to compare and rank effectiveness of different interventions, and test effect modification of intervention effectiveness using subgroup analyses and meta-regression analyses.

Discussion
The results will be important for policymakers when making decisions between multiple possible alternative strategies to prevent CVD. Compared to results from existing multiple separate pairwise meta-analyses, this overarching synthesis of all relevant work will enhance decision-making. The findings will be crucial to inform evidence-based priorities and guidelines for policies and planning prevention strategies of CVD.

Systematic review registration
PROSPERO CRD42019123940.
Coupled elliptic systems depending on the gradient with nonlocal BCs in exterior domains
Authors: Cianciaruso Filomena , Muglia Luigi , Pietramala Paolamaria 
Published: May 2020

AbstractWe study the existence and multiplicity of positive radial solutions for a coupled elliptic system in exterior domains where the nonlinearities depend on the gradients and the boundary conditions are nonlocal. We use a new cone to establish the existence of solutions by means of fixed point index theory.
A secure electronic medical record authorization system for smart device application in cloud computing environments
Authors: Chen Chin-Ling , Huang Po-Tsun , Deng Yung-Yuan , Chen Hsing-Chung , Wang Yun-Ciao 
Published: May 2020

AbstractAs cloud computing technology matures, along with an increased application of distributed networks, increasingly larger amounts of data are being stored in the cloud, and are thus available for pervasive application. At the same time, current independent medical record systems tend to be inefficient, and most previous studies in this field fail to meet the security requirements of anonymity and unlinkability. Some proposed schemes are even vulnerable to malicious impersonation attacks. The scheme proposed in this study, therefore, combines public and private clouds in order to more efficiently and securely preserve and manage electronic medical records (EMR). In this paper, a new secure EMR authorization system is proposed, which uses elliptic curve encryption and public-key encryption, providing a health care system with both public and private cloud environments with a message authentication mechanism, allowing the secure sharing of medical resources. The analysis shows that the proposed scheme prevents known attacks, such as replay attacks, man-in-the-middle attacks and impersonation attacks, and provides user anonymity, unlinkability, integrity, non-repudiation, forward and backward security.
Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives
Authors: Cheng Yuan , Tian Ding-Yuan , Wang Yan-Jiang 
Published: May 2020

AbstractAlzheimer’s disease (AD) is the most common type of dementia, and no disease-modifying treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to play a pivotal role in the pathogenesis of AD, and clearance of Aβ from the brain becomes a main therapeutic strategy for AD. Recent studies found that Aβ clearance in the periphery contributes substantially to reducing Aβ accumulation in the brain. Therefore, understanding the mechanism of how Aβ is cleared in the periphery is important for the development of effective therapies for AD. In this review, we summarized recent findings on the mechanisms of Aβ efflux from the brain to the periphery and discuss where and how the brain-derived Aβ is cleared in the periphery. Based on these findings, we propose future strategies to enhance peripheral Aβ clearance for the prevention and treatment of AD. This review provides a novel perspective to understand the pathogenesis of AD and develop interventions for this disease from a systemic approach.
Estimated need for anthelminthic medicines to control soil-transmitted helminthiases in school-aged children, 2020–2030
Authors: Marocco Chiara , Tediosi Fabrizio , Bangert Mathieu , Mupfasoni Denise , Montresor Antonio 
Published: May 2020

Abstract
Background
Soil-transmitted helminthiases (STH) are part of the group of neglected tropical diseases traditionally treated with preventive chemotherapy interventions. In recent years, drug donations have been essential to expanding preventive chemotherapy and achieving progressive control of morbidity from STH. This study aims to evaluate the need for anthelminthic medicines during 2020–2030.

Methods
To estimate the need for anthelminthic medicines, we considered three different scenarios: (1) the control programmes continues to expand coverage and maintains the frequency of drug administration established at baseline; (2) the programmes continues to expand coverage but adapts the frequency of drug administration when the STH prevalence is reduced and (3) the STH programme becomes self-sustainable in some endemic countries.

Results
We estimate that the number of anthelmintic medicines needed to treat school-aged children will increase by 40% by 2025 and by 52% by 2030 if countries do not change the frequency of preventive chemotherapy (scenario 1); that the number of tablets needed will reduce by 32.4% by 2025 and by 49.1% in 2030 if endemic countries reduce the frequency of preventive chemotherapy (scenario 2); and drug donations could be reduced by 54.4% by 2025 and 74.4% by 2030 if some endemic countries could become independent in drug procurement (scenario 3).

Conclusions
The number of anthelmintic medicines needed to achieve elimination of morbidity due to STH in school-aged children will decline during 2020–2030. The decline will be substantial if a number of “upper-middle income” countries in which STH are endemic procure, as expected, anthelminthic medicines independently.
Transmission of ALS pathogenesis by the cerebrospinal fluid
Authors: Mishra Pooja Shree , Boutej Hejer , Soucy Geneviève , Bareil Christine , Kumar Sunny , Picher-Martel Vincent , Dupré Nicolas , Kriz Jasna , Julien Jean-Pierre 
Published: May 2020

AbstractTo test the hypothesis that the cerebrospinal fluid (CSF) could provide a spreading route for pathogenesis of amyotrophic lateral sclerosis (ALS), we have examined the effects of intraventricular infusion during 2 weeks of pooled CSF samples from sporadic ALS patients or control CSF samples into transgenic mice expressing human TDP43WT which do not develop pathological phenotypes. Infusion of ALS-CSF, but not of control CSF, triggered motor and cognitive dysfunction, as well as ALS-like pathological changes including TDP43 proteinopathy, neurofilament disorganization and neuroinflammation. In addition, the neuron-specific translational profiles from peptide analyses of immunoprecipitated ribosomes revealed dysregulation of multiple protein networks in response to ALS-CSF altering cytoskeletal organization, vesicle trafficking, mitochondrial function, and cell metabolism. With normal mice, similar ALS-CSF infusion induced mild motor dysfunction but without significant TDP43 pathology in spinal neurons. We conclude that the CSF from sporadic ALS contains factors that can transmit and disseminate disease including TDP43 proteinopathy into appropriate recipient animal model expressing human TDP43. These findings open new research avenues for the discovery of etiogenic factors for sporadic ALS and for the testing of drugs aiming to neutralize the ALS-CSF toxicity.
Influence of voxel size on forest canopy height estimates using full-waveform airborne LiDAR data
Authors: Wang Cheng , Luo Shezhou , Xi Xiaohuan , Nie Sheng , Ma Dan , Huang Youju 
Published: May 2020

Abstract
Background
Forest canopy height is a key forest structure parameter. Precisely estimating forest canopy height is vital to improve forest management and ecological modelling. Compared with discrete-return LiDAR (Light Detection and Ranging), small-footprint full-waveform airborne LiDAR (FWL) techniques have the capability to acquire precise forest structural information. This research mainly focused on the influence of voxel size on forest canopy height estimates.

Methods
A range of voxel sizes (from 10.0 m to 40.0 m interval of 2 m) were tested to obtain estimation accuracies of forest canopy height with different voxel sizes. In this study, all the waveforms within a voxel size were aggregated into a voxel-based LiDAR waveform, and a range of waveform metrics were calculated using the voxel-based LiDAR waveforms. Then, we established estimation model of forest canopy height using the voxel-based waveform metrics through Random Forest (RF) regression method.

Results and conclusions
The results showed the voxel-based method could reliably estimate forest canopy height using FWL data. In addition, the voxel sizes had an important influence on the estimation accuracies (R2 ranged from 0.625 to 0.832) of forest canopy height. However, the R2 values did not monotonically increase or decrease with the increase of voxel size in this study. The best estimation accuracy produced when the voxel size was 18 m (R2 = 0.832, RMSE = 2.57 m, RMSE% = 20.6%). Compared with the lowest estimation accuracy, the R2 value had a significant improvement (33.1%) when using the optimal voxel size. Finally, through the optimal voxel size, we produced the forest canopy height distribution map for this study area using RF regression model. Our findings demonstrate that the optimal voxel size need to be determined for improving estimation accuracy of forest parameter using small-footprint FWL data.
Vitamin D status in idiopathic Parkinson’s disease: an Egyptian study
Authors: Fahmy Ebtesam Mohamed , Elawady Mohamed Elsayed , Sharaf Sahar , Heneidy Sarah , Ismail Rania Shehata 
Published: May 2020

Abstract
Background
Vitamin D is suggested to play an important role in neurodegenerative disorders.

Objective
To examine the association between serum 25 vitamin D3 and Parkinson’s disease (PD).

Materials and methods
Fifty patients suffering from PD and fifty age- and sex-matched healthy control subjects were included in the study. Patients were subjected to complete clinical assessment, and Unified Parkinson Disease Rating Scale (UPDRS) was done to evaluate severity of PD. Measurement of serum 25 vitamin D3 using enzyme-linked immuno sorbent assay (ELISA) was done for both patients and controls.

Results
Serum 25 vitamin D3 was significantly lower in PD patients compared to healthy controls. Twenty-five vitamin D3 serum level was significantly negatively correlated with age and age at onset of disease but not significantly correlated with disease duration and severity of Parkinson’s disease. Multiple regression analysis showed that serum 25 vitamin D3 was not found to be predictor for severity of PD.

Conclusion
There is an association between low vitamin D levels and PD. Therefore, vitamin D may have a role in the pathophysiology of PD.
OR18-01 Effect of Teprotumumab on Proptosis Reduction Across Various Demographic Sub-Groups
Authors: Kahaly George J , Smith Terry J , Holt Robert , Sile Saba , Douglas Raymond S 
Published: May 2020

Abstract
Introduction: Teprotumumab, an insulin-like growth factor 1 receptor inhibitory monoclonal antibody, was recently shown to significantly reduce proptosis in patients with active, moderate-to-severe thyroid eye disease (TED) in phase 2 and phase 3 clinical trials.1,2 Prior analyses have demonstrated a combined trial proptosis response (≥2 mm reduction) rate of 77.4% in the teprotumumab group and 14.9% in the placebo group after 24 weeks of therapy (p &lt; 0.001).3 The current analysis was performed to investigate whether or not patient demographic characteristics influence the teprotumumab proptosis response.
Methods: Data from two 24-week randomized, double-masked, placebo-controlled, parallel-group, multicenter studies (Phase 2 [NCT01868997], Phase 3 [NCT03298867[) were combined. All patients had active TED associated with Graves’ disease. The study eye designated at baseline manifested more severe TED and a clinical activity score of &gt; 4. Subjects were divided into subgroups based on gender, smoking status, and age at baseline (younger: &lt;65, older: ≥65). The percentage of proptosis (≥2 mm) responders and proptosis change from baseline were examined in each of these subgroups. Because most of both teprotumumab (85%) and placebo (87%) subjects were white, there were insufficient numbers of subjects to examine the effect of race on the teprotumumab proptosis response. All analyses were performed on the intent-to-treat (ITT) population using data from the study eye.
Results: A total of 171 patients comprised the population from the two studies. Eighty-four and 87 patients were randomized to the teprotumumab and placebo groups, respectively, and the treatment groups had balanced baseline characteristics. At week 24, significantly more teprotumumab than placebo patients were proptosis responders in all examined subgroups (male: 73.1% vs. 5.0%, female: 79.3% vs. 17.9%, smokers: 70.0% vs. 23.1%, non-smokers 79.7% vs. 11.5%, younger: 76.1% vs. 16.2%, older: 84.6% vs. 7.7%; all p &lt; 0.001). In continuous variable analyses, the mean proptosis reduction from baseline was also significantly greater at week 24 in teprotumumab-treated patients than placebo patients (male: -3.34 vs. -0.07 mm, female: -3.10 vs. -0.42 mm, smokers: -2.99 vs. -0.72 mm, non-smokers: -3.20 vs. -0.31 mm, younger: -3.10 vs. -0.39 mm, older: -3.55 vs. -0.22 mm; all p &lt; 0.001).
Conclusion: Teprotumumab was effective across subgroups of age, gender, and smoking status in the pooled 24-week clinical trials.
Reference: (1) Smith TJ, et al. N Engl J Med 2017;376:1748-1761. (2) Douglas RS, et al. AACE 2019 late-breaking abstract. (3) Kahaly GJ, et al. Thyroid 2019;29(Suppl1):A-1 [abstract].
SAT-008 Do Psychological Factors Influence Exercise Related Amenorrhea?
Authors: Williams Nancy I , Strock Nicole C A , Koltun Kristen J , Mallinson Rebecca J , Souza Mary Jane De 
Published: May 2020

Abstract
Purpose: The etiology of functional hypothalamic amenorrhea (FHA) can involve both metabolic and psychogenic stressors. The role of metabolic stress has been described in exercising women who develop FHA secondary to chronic energy deficiency attributable to inadequate dietary intake in the face of exercise training. The potential for psychological factors to contribute to exercise-related FHA is unknown. Methods: In our cross-sectional comparison of exercising women ((n=61), exercise ≥2 hours/week, age 18-35 years, BMI 16-25 kg/m2, we tested whether psychological factors discriminated participants who were deemed eumenorrheic or had FHA as confirmed by physical examination, health history, metabolic and endocrine screening, menstrual calendars and daily urinary collection for reproductive hormone metabolites. Body composition, energy balance, and metabolic and endocrine parameters were assessed in addition to psychological factors (Dysfunctional Attitudes Scale, Brief-Resilient Coping, Daily Stress Inventory, Perceived Stress Scale (PSS), Profile of Mood States (POMS), Beck Depression Inventory) and eating behaviors (Eating Disorder Inventory-2, Three-Factor Eating Questionnaire). Results: Exercising women with FHA had a significantly lower BMI (20.2 vs 21.5 m/kg2, p&lt;0.05), less body fat (22.8 vs 25.8%, p&lt;0.05), and a lower fat mass (56.2 vs 58.3 kg, p&lt;0.05), compared to eumenorrheic women. Fasting total triiodothyronine (75.4 vs 89.8 ng/dL, p&lt;0.001), leptin (5.2 vs 9.0 ng/dL, p&lt;0.01), and the ratio of actual to predicted resting metabolic rate (0.84 vs 0.92, p&lt;0.01) were significantly lower in FHA women. FHA women demonstrated a greater drive for thinness (2.9 vs 2.1, p&lt;0.05), greater dietary cognitive restraint (11.3 vs 7.4, p&lt;0.001), and displayed more dysfunctional attitudes, i.e., need for social approval (39.1 vs 33.7, p&lt;0.05) compared to eumenorrheic women but there were no differences in perceived stress, depression, mood states, brief resilient coping, or daily stress (p &gt;0.05). Notably, FHA women displayed a significant positive correlation between need for social approval and indicators of stress (PSS: r=0.50), depression (Beck: r=0.59), and mood (POMS-depression/dejection: r=0.55), which was not apparent in eumenorrheic women. Additionally, EDI-drive for thinness was significantly positively correlated with many of the variables associated with stress (PSS: r=0.47), depression (Beck: r=0.51), dysfunctional attitudes (r=0.55), and mood disorders (POMS-depression-dejection: r= 0.37; tension/anxiety: r=0.44)(all p&lt;0.05). Conclusion: In exercising women, psychological factors do not overtly discriminate reproductive status; however, in women with FHA, there appears to be a higher need for social approval and restrictive eating behaviors may be related to underlying indicators of psychological stress and depression.
US DoD PR054531
MON-638 The WBC Differential in Relation to DKA Severity
Authors: Alamri Bader Nasser , Ferris Jaclyn , Matheson Kara , De Tugwell Barna 
Published: May 2020

Abstract
BACKGROUND: Diabetic ketoacidosis (DKA) is well-known to be associated with increased levels of inflammatory markers including cytokines. Interestingly, an elevated white blood count (WBC) has been associated with a higher prevalence of acute and chronic diabetes metabolic complications, including DKA, and micro- and macrovascular complications (Tong et al., 2004; Xu et al., 2013). However, very few studies have looked at the relationship between WBC differential and the severity of DKA. For instance, a study looking at platelet-to-lymphocyte ratio found it to be a significant predictor of mortality in DKA patients admitted to the intensive care unit (Liu et al., 2016).
Aim: The goal of the present study is to investigate the relationship between the WBC differential and the severity of DKA.
Method: This study was conducted at Dalhousie University-affiliated hospitals in Nova Scotia, Canada. Ethics approval was obtained. The medical records of 646 emergency visits for 338 patients between November 2015 to December 2018 with a provisional diagnosis of DKA were retrospectively reviewed. 84 records were excluded due to non-anion gap metabolic acidosis, and 66 were excluded due to radiological or microbiological evidence of infection (positive urine, stool or blood cultures, pneumonia, etc.). Only the first set of blood investigations were analyzed to avoid post-treatment changes in blood composition. WBC differential (neutrophils, basophils, eosinophils, immature granulocyte, lymphocytes, metamyelocytes, monocytes, and myelocytes) and severity of DKA based on pH value (mild: 7.25–7.30, moderate: 7.24-7.00, and severe: &lt;7.00) were analyzed.
Result: A total of 496 visits for 277 patients were analyzed, with about 1:1.2 male-to-female ratio and median age of 36.5 years (range 18–90 years), with no significant differences in sex or age in relation to the severity of DKA (P-value= 0.68 and 0.16, respectively). Leukocytosis (WBC &gt;11 x10(9)/L) was seen in 65% (n=314). 32% (n=158) had mild DKA, while 56% (n=273) and 1% (n=57) had moderate and severe DKA, respectively.
With increased severity of DKA, higher WBC count and hemoglobin levels were observed (P-value= 0.002 and 0.037, respectively). This is not unexpected due to hemoconcentration. However, monocytes, immature granulocytes, and basophils (percentage unit of the total WBC) increased with the severity of DKA (P-value: 0.004, &lt;0.001, and &lt;0.001, respectively). On the other hand, lymphocytes displayed an inverse relationship to DKA severity (P-value: 0.015). In contrast, eosinophils & neutrophils had no significant correlation to the DKA severity (P-value= 0.96, and 0.44, respectively).
Conclusion: The WBC differential (namely, monocytes, immature granulocytes, basophils, & lymphocytes) is associated with the severity of DKA. We propose that the WBC differential be further studied as a prognostic indicator in patients with DKA.