bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gap between patients with schizophrenia and their psychiatrists on the needs to psychopharmacological treatment: A cross‐sectional study
Authors: Takahashi Kie , Yamazawa Ryoko , Suzuki Takefumi , Mimura Masaru , Uchida Hiroyuki 
Published: June 2020

AbstractAimPsychopharmacological treatment is indispensable in patients with schizophrenia but data on needs, preferences, and complaints about their medications are limited. Moreover, there has been no study to assess the degree of awareness of their psychiatrists (gap in needs) regarding these issues.MethodsNinety‐seven Japanese patients with schizophrenia (ICD‐10) were asked to fill in the questionnaire consisting of multiple‐choice questions regarding (a) their needs and complaints about psychopharmacological treatment that they were receiving, and (b) their preference of dosage form, dosing frequency, and timing of dosing. Additionally, their psychiatrists in charge were asked to predict their patients’ response to the above questions.ResultsBoth the most frequently endorsed need and complaints about the current psychopharmacological treatment were “nothing in particular” (n = 14, 16.7% and n = 17, 20.2%); merely 23.1% and 15.4% of their psychiatrists correctly predicted these responses, respectively. “Once a day” (n = 56, 65.1%), “at bedtime” (n = 53, 61.6%), and “tablet” (n = 51, 59.3%) were the patients’ most favorite dosing frequency, timing, and dosage form, respectively; 59.8% (n = 49), 54.9% (n = 45), and 64.6% (n = 53) of their psychiatrists predicted them.ConclusionsThese findings suggest that there is substantial room for improvement on the side of psychiatrists to capture their patients’ needs and complaints about psychopharmacological treatment.
Ab Initio Chemical Kinetics for Nitrogen Tetroxide Reactions with 1,1‐ and 1,2‐Dimethylhydrazines
Authors: Le Huyen Trinh , Raghunath Putikam , Chang Lin Ming 
Published: June 2020

AbstractThis work employed the quantum‐chemical method at the CCSD(T)/6‐311+G(3df,2p)//B3LYP/6‐311+G(3df,2p) level to study the mechanisms and kinetics of N2O4 (NTO) with H2NN(CH3)2 and CH3NHNHCH3 hypergolic initiation reactions, the processes critical to the chemical rocket propulsion of the N2O4‐hydrazine propellant systems. The reaction of N2O4 with the dimethylhydrazines (DMHZ's) can be started by the fast reaction of DMHZ's with ONONO2, taking place after the novel N2O4→ONONO2 transformation with each of DMHZ's as a spectator within the NTO‐DMHZ collision complexes, through loose, roaming‐like transition states during the bimolecular encounters. The barriers for such isomerization processes were found to be 7.2 and 9.9 kcal/mol for H2NN(CH3)2 and CH3NHNHCH3, respectively. The kinetics of these reactions have been computed in the temperature range 200–2000 K; the results indicate that under the ambient temperature and pressure condition, the half‐life of NTO in the presence of an excess amount of H2NN(CH3)2 is predicted to be 3.3×10−5 s. The results of a similar estimate for CH3NHNHCH3 is about 2 orders of magnitude longer; both estimates indicate that very effective hypergolic reactions can occur upon mixing in these systems.
Growth or profit? Strategic orientations and long‐term performance in China
Authors: Zhou Nan , Park Seung H. 
Published: June 2020

AbstractResearch summaryThis study investigates the long‐term performance of growth‐oriented versus profit‐oriented strategies in emerging markets. Theoretical justifications exist for superior performance for both types of strategic orientations, but we argue each orientation will have different implications on firms' long‐term survival in emerging markets. The growth‐oriented strategy faces a shortage of non‐scale free resources that would limit the firm's long‐term survival, while the profit‐oriented strategy would improve the chance of long‐term survival by developing and leveraging firm‐specific advantages for sustained growth. The study also examines the moderating effects of both the level of non‐scale free resources and the extent to which the economic context favors growth. The empirical testing utilizes a sample of Chinese firms during 2008–2017.Managerial summaryEmerging markets present many growth opportunities. Firms often fall into the trap of blindly pursuing these opportunities without considering internal managerial capability. This study presents the theory‐based logic and empirical evidence supporting the view that the profit‐oriented strategy is likely to outperform the growth‐oriented strategy on a long‐term basis. The growth orientation strains managerial attention that is in short supplies in emerging markets and leads to inefficiencies that cause a decline in firm performance. These results are more apparent when firms lack managerial capability and in the context of growth‐inducing economic policy during an economic downturn.
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress
Authors: Christoforou Efthimia R. , Sferruzzi-Perri Amanda N. 
Published: June 2020

AbstractThe results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as ‘developmental programming’, whereby the presence of a stressor during gestation predisposes the growing fetus to develop diseases, such as metabolic dysfunction in later postnatal life. However, in a clinical setting, human lifespan and inaccessibility to tissue for analysis are major limitations to study the molecular mechanisms governing developmental programming. Subsequently, studies using animal models have proved indispensable to the identification of key molecular pathways and epigenetic mechanisms that are dysregulated in metabolic organs of the fetus and adult programmed due to an adverse gestational environment. Rodents such as mice and rats are the most used experimental animals in the study of developmental programming. This review summarises the molecular pathways and epigenetic mechanisms influencing alterations in metabolic tissues of rodent offspring exposed to in utero stress and subsequently programmed for metabolic dysfunction. By comparing molecular mechanisms in a variety of rodent models of in utero stress, we hope to summarise common themes and pathways governing later metabolic dysfunction in the offspring whilst identifying reasons for incongruencies between models so to inform future work. With the continued use and refinement of such models of developmental programming, the scientific community may gain the knowledge required for the targeted treatment of metabolic diseases that have intrauterine origins.
Characteristics of Tsunami Fragility Functions Developed Using Different Sources of Damage Data from the 2018 Sulawesi Earthquake and Tsunami
Authors: Mas Erick , Paulik Ryan , Pakoksung Kwanchai , Adriano Bruno , Moya Luis , Suppasri Anawat , Muhari Abdul , Khomarudin Rokhis , Yokoya Naoto , Matsuoka Masashi , Koshimura Shunichi 
Published: June 2020

AbstractWe developed tsunami fragility functions using three sources of damage data from the 2018 Sulawesi tsunami at Palu Bay in Indonesia obtained from (i) field survey data (FS), (ii) a visual interpretation of optical satellite images (VI), and (iii) a machine learning and remote sensing approach utilized on multisensor and multitemporal satellite images (MLRS). Tsunami fragility functions are cumulative distribution functions that express the probability of a structure reaching or exceeding a particular damage state in response to a specific tsunami intensity measure, in this case obtained from the interpolation of multiple surveyed points of tsunami flow depth. We observed that the FS approach led to a more consistent function than that of the VI and MLRS methods. In particular, an initial damage probability observed at zero inundation depth in the latter two methods revealed the effects of misclassifications on tsunami fragility functions derived from VI data; however, it also highlighted the remarkable advantages of MLRS methods. The reasons and insights used to overcome such limitations are discussed together with the pros and cons of each method. The results show that the tsunami damage observed in the 2018 Sulawesi event in Indonesia, expressed in the fragility function developed herein, is similar in shape to the function developed after the 1993 Hokkaido Nansei-oki tsunami, albeit with a slightly lower damage probability between zero-to-five-meter inundation depths. On the other hand, in comparison with the fragility function developed after the 2004 Indian Ocean tsunami in Banda Aceh, the characteristics of Palu structures exhibit higher fragility in response to tsunamis. The two-meter inundation depth exhibited nearly 20% probability of damage in the case of Banda Aceh, while the probability of damage was close to 70% at the same depth in Palu.
Selection properties of the split interval and the Continuum Hypothesis
Authors: Banakh Taras 
Published: June 2020

AbstractWe prove that every usco multimap $$\varPhi :X\rightarrow Y$$

Φ
:
X
→
Y

from a metrizable separable space X to a GO-space Y has an $$F_\sigma $$

F
σ

-measurable selection. On the other hand, for the split interval $${\ddot{\mathbb I}}$$

I
¨

and the projection $$P:{{\ddot{\mathbb I}}}^2\rightarrow \mathbb I^2$$

P
:

I
¨

2

→

I
2

of its square onto the unit square $$\mathbb I^2$$

I
2

, the usco multimap $${P^{-1}:\mathbb I^2\multimap {{\ddot{\mathbb I}}}^2}$$

P

-
1

:

I
2

⊸

I
¨

2

has a Borel ($$F_\sigma $$

F
σ

-measurable) selection if and only if the Continuum Hypothesis holds. This CH-example shows that know results on Borel selections of usco maps into fragmentable compact spaces cannot be extended to a wider class of compact spaces.
Optimising dividends and consumption under an exponential CIR as a discount factor
Authors: Eisenberg Julia , Mishura Yuliya 
Published: June 2020

AbstractWe consider an economic agent (a household or an insurance company) modelling its surplus process by a deterministic process or by a Brownian motion with drift. The goal is to maximise the expected discounted spending/dividend payments under a discounting factor given by an exponential CIR process. In the deterministic case, we are able to find explicit expressions for the optimal strategy and the value function. For the Brownian motion case, we are able to show that for a special parameter choice the optimal strategy is a constant-barrier strategy.
An axiomatic foundation of conditional logit
Authors: Breitmoser Yves 
Published: June 2020

AbstractThis paper considers a decision maker choosing from a set of options when options have multiple real-valued attributes. Assuming DM chooses all options with positive probability, four invariance assumptions are necessary and sufficient for choice probabilities to take McFadden’s conditional logit form: independence of irrelevant alternatives, translation invariance, presentation independence and context independence. Variations on these assumptions yield generalized logit and contextual logit models. This shows that even specific logit models have behavioral foundations in simple invariance assumptions involving observables only, which therefore are directly testable.
Foraging ecology of a marine top predator in the Eastern Tropical Pacific over 3 years with different ENSO phases
Authors: Lerma Miriam , Castillo-Guerrero José Alfredo , Hernández-Vázquez Salvador , Garthe Stefan 
Published: June 2020

AbstractThe El Niño Southern Oscillation (ENSO) is a recurrent climatic pattern with important ecological consequences for seabirds due to its impacts on the abundance and distribution of food resources. We investigated the effects of ENSO phases on the foraging ecology of a marine top predator at Clarion Island in the Eastern Tropical Pacific using GPS and time-depth recorder data and regurgitates from incubating masked boobies (Sula dactylatra) during 3 consecutive years. Foraging locations were recorded in 2016 (El Niño, one female, three males), 2017 (neutral; six females, nine males), and 2018 (La Niña; eight females, ten males). Local sea surface temperature (SST) and chlorophyll-a concentration (CHL) within the birds’ foraging range were compared among the 3 years. Regurgitates were collected opportunistically from 25 and 31 incubating adults in 2017 and 2018, respectively. Average local CHL and SST were similar among years (mean SST 25 °C; mean CHL 0.10 and of 0.09 mg m−3in January and March, respectively). Masked boobies travelled a maximum of 66 ± 34 km from the colony. The maximum trip duration was 7.7 ± 3.4 h and total distance travelled during a foraging trip was 164 ± 73 km, with no sex- or year-related differences. Masked boobies mainly caught flying fish, but their diet also included one squid and six other fish families. In contrast to previously reported changes in foraging ecology of seabirds, masked boobies at Clarion Island seemed to be unaffected during El Niño, because the local oceanography was relatively unperturbed by ENSO oscillations.
Aggregation and analysis of indication-symptom relationships for drugs approved in the USA
Authors: Punyala Ananth , Lankapalli Rachana , Hindman Diane , Racz Rebecca 
Published: June 2020

Abstract
Purpose
Drug indications and disease symptoms often confound adverse event reports in real-world datasets, including electronic health records and reports in the FDA Adverse Event Reporting System (FAERS). A thorough, standardized set of indications and symptoms is needed to identify these confounders in such datasets for drug research and safety assessment. The aim of this study is to create a comprehensive list of drug-indication associations and disease-symptom associations using multiple resources, including existing databases and natural language processing.

Methods
Drug indications for drugs approved in the USA were extracted from two databases, RxNorm and Side Effect Resource (SIDER). Symptoms for these indications were extracted from MedlinePlus and using natural language processing from PubMed abstracts.

Results
A total of 1361 unique drugs, 1656 unique indications, and 2201 unique symptoms were extracted from a wide variety of MedDRA System Organ Classes. Text-mining precision was maximized at 0.65 by examining Term Frequency Inverse Document Frequency (TF-IDF) scores of the disease-symptom associations.

Conclusion
The drug-indication associations and disease-symptom associations collected in this study may be useful in identifying confounders in other datasets, such as safety reports. With further refinement and additional drugs, indications, and symptoms, this dataset may become a quality resource for disease symptoms.
Tame torsion, the tame inverse Galois problem, and endomorphisms
Authors: Bisatt Matthew 
Published: June 2020

AbstractFix a positive integer g and rational prime p. We prove the existence of a genus g curve $$C/\mathbb {Q}$$

C
/
Q

such that the mod p representation of its Jacobian is tame by imposing conditions on the endomorphism ring. As an application, we consider the tame inverse Galois problem and are able to realise general symplectic groups as Galois groups of tame extensions of $$\mathbb {Q}$$
Q
.
The ovulation trigger–OPU time interval of different ovarian protocols in ART: a retrospective study
Authors: Shen Xi , Long Hui , Guo Wenya , Xie Yating , Gao Hongyuan , Zhang Jie , Wang Yun , Lyu Qifeng , Kuang Yanping , Wang Li 
Published: June 2020

Abstract
Purpose
To explore the trends of oocyte and pregnancy outcomes over the ovulation trigger–OPU (oocyte pickup) time interval in four mainly used COH protocols.

Methods
This retrospective study was conducted between January 2013 and July 2018. The IVF/ICSI cycles of the patients with normal ovarian reserve were included. The number of total patients was 4673, which consisted of long agonist protocol (n = 819), short agonist protocol (n = 1703), mild stimulation protocol (n = 1627), and GnRH antagonist protocol (n = 524). The primary outcome was mature oocyte rate.

Results
The ovulation trigger–OPU time interval and COH protocol were related to cycles with > 80% MII oocytes. Four protocols showed apparently different trends of retrieved oocyte rate and mature oocyte rate over the ovulation trigger–OPU time interval, and the long agonist protocol had the most delayed time interval than other three COH protocols in retrieving more than 60% oocytes (35.4–39.6 h vs. 34.6–38.6 h vs. 32.5–37.5 h vs. 33.8–37.7 h) and getting more than 80% mature oocytes (35.0–39.7 h vs. 36.0–37.7 h vs. 34.1–35.5 h vs. 34.5–36.3 h). And the adjusted odds ratio (OR) of the cumulative live birth rate (CLBR) (OR 1.360, 95% Confidence Interval (CI) 1.156–1.549, P < 0.05) significantly increased with the trigger–OPU time interval in the long agonist protocol.

Conclusions
For getting more and mature oocytes, the ovulation trigger–OPU time intervals should be gradually prolonged from the mild stimulation protocol, the GnRH antagonist protocol, and the short protocol to the long agonist protocol. And the prolonged ovulation trigger–OPU time interval in the long agonist protocol brings higher live birth rate (LBR) and CLBR.
Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer
Authors: Hui Zhenzhen , Wei Feng , Ren Hongliang , Xu Wengui , Ren Xiubao 
Published: June 2020

Abstract
Purpose
The combined small-cell lung cancer (c-SCLC) is rare and has unique clinicopathological futures. The aim of this study is to investigate 18F-FDG PET/CT parameters and clinicopathological factors that influence the prognosis of c-SCLC.

Methods
Between November 2005 and October 2014, surgical-resected tumor samples from c-SCLC patients who received preoperative 18F-FDG PET/CT examination were retrospectively reviewed. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were used to evaluate metabolic parameters in primary tumors. The survivals were evaluated with the Kaplan–Meier method. Univariate and multivariate analyses were used to evaluate potential prognostic factors.

Results
Thirty-one patients were enrolled, with a median age of 62 (range: 35 − 79) years. The most common mixed component was squamous cell carcinoma (SCC, n = 12), followed by large-cell carcinoma (LCC, n = 7), adenocarcinoma (AC, n = 6), spindle cell carcinoma (n = 4), adenosquamous carcinoma (n = 1) and atypical carcinoid (n = 1). The median follow-up period was 53.0 (11.0–142.0) months; the 5-year overall survival (OS) and progression-free survival(PFS) rate were 48.4% and 35.5%, respectively. Univariate survival analysis showed that gender, smoking history, tumor location were associated with PFS (P = 0.036, P = 0.043, P = 0.048), SUVmax and TNM stage were closely related to PFS in both Mixed SCC and non-SCC component groups (P = 0.007, P = 0.048). SUVmax, smoking history, tumor size and mixed SCC component were influencing factors of OS in patients (P = 0.040, P = 0.041, P = 0.046, P = 0.029). Multivariate survival analysis confirmed that TNM stage (HR = 2.885, 95%CI: 1.323–6.289, P = 0.008) was the most significantly influential factor for PFS. High SUVmax value (HR = 9.338, 95%CI: 2.426–35.938, P = 0.001) and mixed SCC component (HR = 0.155, 95%CI: 0.045–0.530, P = 0.003) were poor predictors for OS.

Conclusion
Surgical-resected c-SCLCs have a relatively good prognosis. TNM stage is the most significant factor influencing disease progression in surgical-resected c-SCLCs. SUVmax and mixed NSCLC components within c-SCLCs had a considerable influence on the survival. Both high SUVmax and mixed SCC component are poor predictors for patients with c-SCLCs.
Plasticity of seasonal xylem and phloem production of Norway spruce along an elevational gradient
Authors: Miller Tobias Walter , Stangler Dominik Florian , Larysch Elena , Seifert Thomas , Spiecker Heinrich , Kahle Hans-Peter 
Published: June 2020

AbstractKey messagePhloem cell production was less influenced by environmental factors than xylem cell production. The moment of maximum number of conducting phloem cells occurred at the end of the growing season.AbstractThe understanding of the seasonality of phloem production, its dependence on climatic factors and potential trade-offs with xylem cell production is still limited. This study determined key tree-ring phenological events and examined the dynamics of phloem and xylem cell production of Norway Spruce (Picea abies(L.) Karst) by sampling microcores during the growing seasons 2014 and 2015 along an elevational gradient (450 m, 750 m, 1250 m a.s.l.) in south-western Germany. The onset of phloem formation preceded xylem formation at each elevation by approximately 2 weeks, while cessation showed no clear differences between the stands. Maximum rates of xylem and phloem cell production were observed around the summer solstice, independent of elevation. No linear pattern was found in the occurrence of phenological events along the elevational gradient. Phloem formation appeared to be less sensitive to environmental conditions since no difference was found in the number of produced sieve cells between the 2 years of study, whereas the ratio of xylem to phloem cells was significantly smaller in the year 2015 with summer drought. The total number of conducting, non-collapsed phloem cells did not culminate as expected at the time of the potential maximum assimilate production, but at the end of the growing season. Thus, interpretation of phloem formation should not be limited to the function of assimilate transport but should follow a more holistic view of structural–functional relationships of conductive tissues and tree physiological processes.
Single center experiences with telemetric intracranial pressure measurements in patients with CSF circulation disturbances
Authors: Pennacchietti Valentina , Prinz Vincent , Schaumann Andreas , Finger Tobias , Schulz Matthias , Thomale Ulrich W. 
Published: June 2020

Abstract
Background
Hydrocephalus may present with heterogeneous signs and symptoms. The indication for its treatment and the optimal drainage in complex cases may be challenging. Telemetric intracranial pressure measurements (TICPM) may open new perspectives for those circumstances. We report our experiences using the Neurovent-P-tel and the Sensor Reservoir in a retrospective study.

Methods
A series of 21 patients (age range 10–39.5 years) treated in our Pediatric Neurosurgical Unit receiving a TICPM was analyzed. In 8 patients, a Neurovent-P-Tel was implanted; 13 patients received a Sensor Reservoir, 6 of which as a stand-alone implant, while 7 were already shunted. TICPM were performed on an outpatient basis. Possible complications, follow-up surgeries, and TICPM were analyzed.

Results
Concerning the complications, one infection was seen in each group and one postoperative seizure was observed in the P-tel group. TICPM-assisted shunt adjustments lead to clinical improvements in six patients in the P-tel group and six patients in the Sensor Reservoir group. In four out of six non-shunted patients, TICPM contributed to the indication toward shunt implantation.

Conclusions
TICPM seems to be a promising tool to improve clinical management of shunted patients with complex hydrocephalus. The two available systems will need further technical improvements, concerning implantation time, measurements, and data analysis in order to optimize handling and interpretation of the data.