bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of neonatal infections in hospitals of Nepal: evidence from a large- scale study
Authors: Budhathoki Shyam Sundar , Sunny Avinash K. , Paudel Pragya Gautam , Thapa Jeevan , Basnet Lila Bahadur , Karki Sandeepa , Gurung Rejina , Paudel Prajwal , KC Ashish 
Published: May 2020

Abstract
Background
Every year, neonatal infections account for approximately 750,000 neonatal deaths globally. It is the third major cause of neonatal death, globally and in Nepal. There is a paucity of data on clinical aetiology and outcomes of neonatal infection in Nepal. This paper aims to assess the incidence and risk factors of neonatal infection in babies born in public hospitals of Nepal.

Methods
This is a prospective cohort study conducted for a period of 14 months, nested within a large-scale cluster randomized control trial which evaluated the Helping Babies Breathe Quality Improvement package in 12 public hospitals in Nepal. All the mothers who consented to participate within the study and delivered in these hospitals were included in the analysis. All neonates admitted into the sick newborn care unit weighing > 1500 g or/and 32 weeks or more gestation with clinical signs of infection or positive septic screening were taken as cases and those that did not have an infection were the comparison group. Bivariate and multi-variate analysis of socio-demographic, maternal, obstetric and neonatal characteristics of case and comparison group were conducted to assess risk factors associated with neonatal infection.

Results
The overall incidence of neonatal infection was 7.3 per 1000 live births. Babies who were born to first time mothers were at 64% higher risk of having infection (aOR-1.64, 95% CI, 1.30–2.06, p-value< 0.001). Babies born to mothers who had no antenatal check-up had more than three-fold risk of infection (aOR-3.45, 95% CI, 1.82–6.56, p-value< 0.001). Babies born through caesarean section had more than two-fold risk (aOR-2.06, 95% CI, 1.48–2.87, p-value< 0.001) and babies with birth asphyxia had more than three-fold risk for infection (aOR-3.51, 95% CI, 1.71–7.20, p-value = 0.001).

Conclusion
Antepartum factors, such as antenatal care attendance, and intrapartum factors such as mode of delivery and birth asphyxia, were risk factors for neonatal infections. These findings highlight the importance of ANC visits and the need for proper care during resuscitation in babies with birth asphyxia.
Smartphone apps for managing alcohol consumption: a literature review
Authors: Colbert Stephanie , Thornton Louise , Richmond Robyn 
Published: May 2020

Abstract
Background
Smartphone applications (apps) designed to assist users to reduce hazardous and harmful alcohol consumption show potential as an inexpensive alternative to traditional brief intervention in primary care. The aim of this paper is to provide an overview of the literature on alcohol reduction apps and the availability of evidenced-based apps on top commercial app stores.

Methods
We reviewed literature through to December 2019 using the databases PubMed, MEDLINE, PsycINFO and Google Scholar and keyword search terms smartphone/mobile/phone AND application/app AND alcohol. Articles were included if the primary intervention was a smartphone app and the study measured participant changes in frequency or volume of alcohol consumption.

Results
21 relevant articles were identified that evaluated 19 unique smartphone apps. Of the 19 unique apps, seven were designed for use among youth and 12 in adult populations. The available evidence for the efficacy of alcohol reduction apps among youth is inconclusive, with results from these evaluations not showing a clear benefit in reducing alcohol consumption compared to control groups. The results of apps designed for adult populations appears more promising, but results are still mixed. Of the 19 alcohol reduction apps that have been evaluated only eight of these are currently publicly available in commercial app stores. Of these eight apps, only four were demonstrated in the literature to assist with reducing alcohol consumption.

Conclusion
The evidence for alcohol reduction apps is promising but inconclusive. Few apps that have been evaluated in the scientific literature are currently available for download in commercial app stores.
Correction to: Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review
Authors: Donà D. , Barbieri E. , Daverio M. , Lundin R. , Giaquinto C. , Zaoutis T. , Sharland M. 
Published: May 2020

The original article [1] contains an error in Fig. 1 whereby the number of selected articles of the first box is incorrect.
Determinants of delayed diagnosis and treatment of tuberculosis in Cambodia: a mixed-methods study
Authors: Teo Alvin Kuo Jing , Ork Chetra , Eng Sothearith , Sok Ngovlyly , Tuot Sovannary , Hsu Li Yang , Yi Siyan 
Published: May 2020

Abstract
Background
Cambodia is among the 30 countries in the world with the highest burden of tuberculosis (TB), and it is estimated that 40% of people with TB remain undiagnosed. In this study, we aimed to investigate the determinants of delayed diagnosis and treatment of TB in Cambodia.

Methods
This mixed-method explanatory sequential study was conducted between February and September 2019 in 12 operational districts in Cambodia. It comprised of a retrospective cohort study of 721 people with TB, followed by a series of in-depth interviews. We assessed factors associated with time to TB diagnosis and treatment initiation using Cox proportional hazards model. Subsequently, we conducted in-depth interviews with 31 people with TB purposively selected based on the time taken to reach TB diagnosis, sex, and residence. Transcripts were coded, and thematic analyses were performed.

Results
The median time from the onset of symptoms to TB diagnosis was 49 days (Interquartile range [IQR]: 21–112). We found that longer time to diagnosis was significantly associated with living in rural area (Adjusted hazards ratio [aHR] = 1.25; 95% confidence interval [CI]: 1.06–1.48); TB symptoms—cough (aHR: 1.52; 95% CI: 1.18–1.94), hemoptysis (aHR 1.32; 95% CI: 1.07–1.63), and night sweats (aHR: 1.24; 95% CI: 1.05–1.46); seeking private health care/self-medication (aHR: 1.23; 95% CI: 1.04–1.45); and higher self-stigma (aHR: 1.02; 95% CI: 1.01–1.03). Participants who received education level above the primary level were inversely associated with longer time to diagnosis (aHR: 0.78; 95% CI: 0.62–0.97). The median time from TB diagnosis to the initiation of treatment was two days (IQR: 1–3). The use of smear microscopy for TB diagnosis (aHR: 1.50; 95% CI: 1.16–1.95) was associated with longer time to treatment initiation. Seeking private health care and self-medication before TB diagnosis, lack of perceived risk, threat, susceptibility, and stigma derived qualitatively further explained the quantitative findings.

Conclusions
TB diagnostic delay was substantial. Increasing public awareness about TB and consciousness regarding stigma, engaging the private healthcare providers, and tailoring approaches targeting the rural areas could further improve early detection of TB and narrowing the gap of missing cases in Cambodia.
Magmatic–hydrothermal system of Aso Volcano, Japan, inferred from electrical resistivity structures
Authors: Matsushima Nobuo , Utsugi Mitsuru , Takakura Shinichi , Yamasaki Tadashi , Hata Maki , Hashimoto Takeshi , Uyeshima Makoto 
Published: May 2020

AbstractWe investigated the magmatic–hydrothermal system of Aso Volcano, Japan, using broadband magnetotelluric (MT) data. To establish the nature of the shallow crust, a previous resistivity model based on data from 100 measurement sites in and around Aso volcano was revised using data from 9 additional sites near Naka-dake crater, which is located in the central part of the volcano. The components of MT impedance and the tipper vector were used to obtain the resistivity structure by three-dimensional inversion. The resistivity structure shows a subvertical low-resistivity (< 1 Ωm) column-shaped body beneath Naka-dake crater that extends from − 600 m to 10 km below sea level (BSL) and dips steeply to the north-northeast. The position of the upper part of the column is displaced eastward compared with the previous model and does not overlap the position of the presumed magma reservoir inferred previously from seismic and geodetic observations underneath the western side of Naka-dake crater at a depth of 5 km. We interpret this low-resistivity column to be a magmatic–hydrothermal system composed of brine and magma that were transported to Naka-dake crater from the main deep-seated magma reservoir. A horizontal low-resistivity (< 10 Ωm) layer occurs beneath post-caldera cones at the depths of 0–2 km BSL, and this layer extends laterally from the upper part of the low-resistivity column. We interpret this low-resistivity layer as representing a shallow hydrothermal system that has developed around the central column-shaped magmatic–hydrothermal system.
Evaluation of a method to retrieve temperature and wind velocity profiles of the Venusian nightside mesosphere from mid-infrared CO2 absorption line observed by heterodyne spectroscopy
Authors: Takami Kosuke , Nakagawa Hiromu , Sagawa Hideo , Krause Pia , Murata Isao , Kasaba Yasumasa , Kuroda Takeshi , Aoki Shohei , Kouyama Toru , Kostiuk Theodor , Livengood Timothy A. , Gilli Gabriella 
Published: May 2020

AbstractWe evaluated a method for retrieving vertical temperature and Doppler wind velocity profiles of the Venusian nightside mesosphere from the CO2 absorption line resolved by mid-infrared heterodyne spectroscopy. The achievable sensitive altitude and retrieval accuracy were derived with multiple model spectra generated from various temperature and wind velocity profiles with several noise levels. The temperature profiles were retrieved at altitudes of 70–100 km with a vertical resolution of 5 km and a retrieval accuracy of ± 15 K. The wind velocity was also retrieved at an altitude of approximately 85 km with a vertical resolution of 10 km and a retrieval accuracy of ± 25–50 m/s. In addition, we studied an event and applied our method to spectra obtained by the HIPWAC instrument attached to the NASA/IRTF 3-m telescope on May 19–22, 2012. Retrieved wind velocities in a latitude of 33° S at 3:00 LT were interpreted as subsolar-to-antisolar (SS-AS) flows at altitudes of 84 ± 6 km and 94 ± 7 km, and they were stronger than expected. This result suggested that the transition between the retrograde superrotational zonal (RSZ) wind and SS-AS flow may occur at altitudes below 90 km which previously was predicted to be the transition region. This work provides a basis for our analysis of further observations obtained by a mid-infrared heterodyne spectrometer MILAHI attached to the Tohoku University 60-cm telescope at Haleakalā, Hawaii.
Simulation study of a coincidence detection system for non-invasive determination of arterial blood time-activity curve measurements
Authors: Toufique Yassine , Bouhali Othmane , Negre Pauline , O’ Doherty Jim 
Published: May 2020

Abstract
Background
Arterial sampling in PET studies for the purposes of kinetic modeling remains an invasive, time-intensive, and expensive procedure. Alternatives to derive the blood time-activity curve (BTAC) non-invasively are either reliant on large vessels in the field of view or are laborious to implement and analyze as well as being prone to many processing errors. An alternative method is proposed in this work by the simulation of a non-invasive coincidence detection unit.

Results
We utilized GATE simulations of a human forearm phantom with a blood flow model, as well as a model for dynamic radioactive bolus activity concentration based on clinical measurements. A fixed configuration of 14 and, also separately, 8 detectors were employed around the phantom, and simulations were performed to investigate signal detection parameters. Bismuth germanate (BGO) crystals proved to show the highest count rate capability and sensitivity to a simulated BTAC with a maximum coincidence rate of 575 cps. Repeatable location of the blood vessels in the forearm allowed a half-ring design with only 8 detectors. Using this configuration, maximum coincident rates of 250 cps and 42 cps were achieved with simulation of activity concentration determined from 15O and 18F arterial blood sampling. NECR simulated in a water phantom at 3 different vertical positions inside the 8-detector system (Y = − 1 cm, Y = − 2 cm, and Y = −3 cm) was 8360 cps, 13,041 cps, and 20,476 cps at an activity of 3.5 MBq. Addition of extra axial detection rings to the half-ring configuration provided increases in system sensitivity by a factor of approximately 10.

Conclusions
Initial simulations demonstrated that the configuration of a single half-ring 8 detector of monolithic BGO crystals could describe the simulated BTAC in a clinically relevant forearm phantom with good signal properties, and an increased number of axial detection rings can provide increased sensitivity of the system. The system would find use in the derivation of the BTAC for use in the application of kinetic models without physical arterial sampling or reliance on image-based techniques.
An extremely rare case with right superior pulmonary vein translocation
Authors: Kamimura Go , Ueda Kazuhiro , Maeda Koki , Aoki Masaya , Nagata Toshiyuki , Yokomakura Naoya , Sato Masami 
Published: May 2020

Abstract
Background
There have been a number of reports on pulmonary venous anomalies. However, most of the reports focused on the anatomical branching pattern of the peripheral pulmonary veins.

Case presentation
We report a 75-year-old female whose right superior pulmonary vein V1 existed dorsal to the right main pulmonary artery and V2+3 existed dorsal to V4+5. Thus, we could not find V1 and V2+3 in the hilum just after a thoracotomy to perform right upper lobectomy for lung cancer. Thus, the right main pulmonary artery and the superior trunk (A1+3) were exposed without cutting the superior pulmonary vein.

Conclusion
There has been no report so far regarding this type of pulmonary vein translocation. Preoperative three-dimensional computed tomography images were helpful to identify this variant.
Drosophila melanogaster chemical ecology revisited: 2-D distribution maps of sex pheromones on whole virgin and mated flies by mass spectrometry imaging
Authors: Kaftan Filip , Kulkarni Purva , Knaden Markus , Böcker Sebastian , Hansson Bill S. , Svatoš Aleš 
Published: May 2020

Abstract
Background
Sexual behavior in Drosophila melanogaster flies is greatly influenced by chemical cues. In this study, a spatial distribution of female and male sex pheromones was investigated on the surface of virgin and mated six-day-old fruit flies. Surface analysis was performed using the technique of mass spectrometry imaging (MSI) matrix-assisted laser desorption/ionization – time of flight (MALDI-TOF) and confirmed by gas chromatography – mass spectrometry (GC-MS) analysis of hexane extracts prepared from dissected flies.

Results
MALDI-TOF MSI experiments focused on female pheromones (7Z,11Z)-heptacosa-7,11-diene (7,11-HD) and (7Z,11Z)-nonacosa-7,11-diene (7,11-ND) were enhanced by using lithium 2,5-dihydroxybenzoate (LiDHB) matrix to improve the ionization and quality of MS spectra. Oxygenated compounds represented by male anti-attractants 11-cis-vaccenyl acetate (cVA) and 3-O-acetyl-1,3-dihydroxy-octacosa-11,19-diene (CH503) were successfully ionized without MALDI matrix in the form of potassium adducts in laser desorption ionization (LDI-TOF MSI) mode. A similar pattern of distribution for 7,11-HD and 7,11-ND was observed on the surface of both the left and the right female wing, with the strongest signals at the base of the wing. 7,11-HD and 7,11-ND were additionally detected on female legs but not on the body. The distribution of both male pheromones, cVA and CH503, was localized in virgin male flies solely on the abdominal tip and anogenital region. In addition, results from MSI experiments with mated flies showed the distribution of cVA and CH503 also on the female abdomen and thorax, demonstrating that anti-attractants were transferred from males to females during copulation. Results from LDI/MALDI-TOF MSI were supported by GC-MS analysis of hexane extracts prepared from different parts of virgin male or female Drosophila flies. Similar amounts of 7,11-HD and 7,11-ND were present on the legs, body and wings (127 ± 5 ng and 170 ± 8 ng, respectively). cVA was detected only on the male body. All acquired MSI datasets were affected by mass shift (predominantly between ±0.2 Da to ±0.4 Da), which was reduced using a mass recalibration approach.

Conclusions
The LDI/MALDI-TOF MSI technique makes it possible to study the distribution of female and male sexual pheromones on D. melanogaster flies. Moreover, the technique enables the transfer of male sex pheromones to females during copulation to be visualized. However, imaging experiments of 3-D biological samples performed on a single TOF-MS instrument equipped with a MALDI ion source and UV nitrogen laser evinced a photo-electric charging/discharging, a phenomenon that often leads to unpredictable mass shifts and poor mass accuracy.
Early detection of learning difficulties using the BADyG-E2r Battery during primary education
Authors: Navarro Soria Ignasi , García Fernández José Manuel , Inglés Saura Cándido J. , Real Fernández Marta 
Published: May 2020

AbstractThe aim of the present study was to assess the predictive capacity of several of the most relevant cognitive skills in the academic field that were evaluated using Differential and General Skills Battery(BADyG-E2r). Particular attention was focused on the variables that need to be overcome regarding the curricular objectives related to pass/fail grading as evaluated by the teachers in the instrumental disciplines of Mathematics and Language. The psychometric battery was applied to the 3rd year students in primary education (a total of 512 students) at 4 public schools that were randomly selected in the province of Alicante (Spain). A follow-up of their academic evolution was under taken until the end of primary education. The obtained results show that high scores in Verbal Reasoning, Numerical Reasoning, and Verbal Syllogisms positively and significantly predict academic success at the end of primary education in the subjects of Language and Mathematics.
Inverse Laplace transform and multiexponential fitting analysis of T2 relaxometry data: a phantom study with aqueous and fat containing samples
Authors: Ioannidis Georgios S. , Nikiforaki Katerina , Kalaitzakis Georgios , Karantanas Apostolos , Marias Kostas , Maris Thomas G. 
Published: May 2020

Abstract
Background
The inverse Laplace transform (ILT) is the most widely used method for T2 relaxometry data analysis. This study examines the qualitative agreement of ILT and a proposed multiexponential (Mexp method) regarding the number of T2 components. We performed a feasibility study for the voxelwise characterisation of heterogeneous tissue with T2 relaxometry.

Methods
Eleven samples of aqueous, fatty and mixed composition were analysed using ILT and Mexp. The phantom was imaged using a 1.5-T system with a single slice T2 relaxometry 25-echo Carr-Purcell-Meiboom-Gill sequence in order to obtain the T2 decay curve with 25 equidistant echo times. The adjusted R2 goodness of fit criterion was used to determine the number of T2 components using the Mexp method on a voxel-based analysis. Comparison of mean and standard deviation of T2 values for both methods was performed by fitting a Gaussian function to the ILT resulting vector.

Results
Phantom results showed pure monoexponential decay for acetone and water and pure biexponential behaviour for corn oil, egg yolk, and 35% fat milk cream, while mixtures of egg whites and yolks as well as milk creams with 12–20% fatty composition exhibit mixed monoexponential and biexponential behaviour at different fractions. The number of T2 components by the Mexp method was compared to the ILT-derived spectrum as ground truth.

Conclusions
Mexp analysis with the adjusted R2 criterion can be used for the detection of the T2 distribution of aqueous, fatty and mixed samples with the added advantage of voxelwise mapping.
The utility of dual energy computed tomography in the management of axial gout: case reports and literature review
Authors: Wang Jeremy X. , Ng Beverly , Bak Haesung , Spencer David , Manolios Nicholas , Wong Peter K. K. 
Published: May 2020

Abstract
Background
Severe spinal pain is an unusual presentation of gout. Due to its rarity and the difficulty of obtaining joint fluid or tissue for crystal analysis, dual energy computed tomography (DECT) may be a useful imaging modality in the management of axial gout.

Case presentation
Two patients independently presented to a major teaching hospital with severe spinal pain subsequently shown to be due to gout. The first patient presented with back pain and fevers and was initially thought to have lumbar facet joint septic arthritis. The second case presented with severe back pain. In both cases, DECT suggested monosodium urate deposition in spinal tissues as the cause of their presentation.

Conclusions
Axial gout should be considered in the differential diagnosis of severe spinal pain. A DECT study may be a useful diagnostic tool in the management of spinal gout.
A mean free path approach to the micro/nanochannel gas flows
Authors: Xie Jianfei 
Published: May 2020

AbstractWe investigate the gas flows near to solid surfaces in terms of the local spatial variation in the molecular mean free path (MFP). Molecular dynamics (MD) is the appropriate scientific tool for obtaining molecularly-accurate dynamic information in micro and nano-scale gas flows, and has been used to evaluate the molecular mean free path of gases. In the calibration procedure, the viscosity of a gas in the homogeneous case can be recovered in our MD simulations and reach good agreement with the theoretical prediction and data from NIST. In surface-bounded gas flows, if the collisions between gas molecules and walls are counted, a spatially-varying mean free path is presented, and for the first time we have observed that the distribution of the free paths deviates from the exponential one and spikes appear in their distributions at larger Kn, i.e. in the transition flow regime. Based on elementary kinetic theory, the effective viscosity of the gas derived from the mean free path has been incorporated into the framework of the continuum-fluid dynamics equations, and micro-Couette flows are performed to demonstrate this potential application.